data_8X92
# 
_entry.id   8X92 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8X92         pdb_00008x92 10.2210/pdb8x92/pdb 
WWPDB D_1300042926 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8X92 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              bilee@ncc.re.kr 
_pdbx_contact_author.name_first         'Byung Il' 
_pdbx_contact_author.name_last          Lee 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1270-8439 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Park, T.H.' 1 0000-0001-8059-8273 
'Bong, S.M.' 2 0000-0001-8288-1283 
'Lee, S.J.'  3 0009-0002-4180-7583 
'Lee, B.I.'  4 0000-0003-1270-8439 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'crystal structure of rock2 with GNS-2666 inhibitor' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Park, T.H.' 1 ? 
primary 'Lee, B.I.'  2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Rho-associated protein kinase 2'                                                            45028.246 2  
2.7.11.1 ? ? ? 
2 non-polymer syn '~{N}-methyl-3-[[6-(2-methylpyrazol-3-yl)-1-oxidanylidene-isoquinolin-2-yl]methyl]benzamide' 372.420   2  ? ? ? 
? 
3 non-polymer syn 'SULFATE ION'                                                                                96.063    1  ? ? ? 
? 
4 water       nat water                                                                                        18.015    80 ? ? ? 
? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'Rho kinase 2,Rho-associated,coiled-coil-containing protein kinase 2,coiled-coil-containing protein kinase II,ROCK-II,p164 ROCK-2' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEV
QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV
PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG
GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVE
EIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEV
QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV
PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG
GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVE
EIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYR
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '~{N}-methyl-3-[[6-(2-methylpyrazol-3-yl)-1-oxidanylidene-isoquinolin-2-yl]methyl]benzamide' YEW 
3 'SULFATE ION'                                                                                SO4 
4 water                                                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLN n 
1 2   ARG n 
1 3   LYS n 
1 4   LEU n 
1 5   GLU n 
1 6   ALA n 
1 7   LEU n 
1 8   ILE n 
1 9   ARG n 
1 10  ASP n 
1 11  PRO n 
1 12  ARG n 
1 13  SER n 
1 14  PRO n 
1 15  ILE n 
1 16  ASN n 
1 17  VAL n 
1 18  GLU n 
1 19  SER n 
1 20  LEU n 
1 21  LEU n 
1 22  ASP n 
1 23  GLY n 
1 24  LEU n 
1 25  ASN n 
1 26  SER n 
1 27  LEU n 
1 28  VAL n 
1 29  LEU n 
1 30  ASP n 
1 31  LEU n 
1 32  ASP n 
1 33  PHE n 
1 34  PRO n 
1 35  ALA n 
1 36  LEU n 
1 37  ARG n 
1 38  LYS n 
1 39  ASN n 
1 40  LYS n 
1 41  ASN n 
1 42  ILE n 
1 43  ASP n 
1 44  ASN n 
1 45  PHE n 
1 46  LEU n 
1 47  ASN n 
1 48  ARG n 
1 49  TYR n 
1 50  GLU n 
1 51  LYS n 
1 52  ILE n 
1 53  VAL n 
1 54  LYS n 
1 55  LYS n 
1 56  ILE n 
1 57  ARG n 
1 58  GLY n 
1 59  LEU n 
1 60  GLN n 
1 61  MET n 
1 62  LYS n 
1 63  ALA n 
1 64  GLU n 
1 65  ASP n 
1 66  TYR n 
1 67  ASP n 
1 68  VAL n 
1 69  VAL n 
1 70  LYS n 
1 71  VAL n 
1 72  ILE n 
1 73  GLY n 
1 74  ARG n 
1 75  GLY n 
1 76  ALA n 
1 77  PHE n 
1 78  GLY n 
1 79  GLU n 
1 80  VAL n 
1 81  GLN n 
1 82  LEU n 
1 83  VAL n 
1 84  ARG n 
1 85  HIS n 
1 86  LYS n 
1 87  ALA n 
1 88  SER n 
1 89  GLN n 
1 90  LYS n 
1 91  VAL n 
1 92  TYR n 
1 93  ALA n 
1 94  MET n 
1 95  LYS n 
1 96  LEU n 
1 97  LEU n 
1 98  SER n 
1 99  LYS n 
1 100 PHE n 
1 101 GLU n 
1 102 MET n 
1 103 ILE n 
1 104 LYS n 
1 105 ARG n 
1 106 SER n 
1 107 ASP n 
1 108 SER n 
1 109 ALA n 
1 110 PHE n 
1 111 PHE n 
1 112 TRP n 
1 113 GLU n 
1 114 GLU n 
1 115 ARG n 
1 116 ASP n 
1 117 ILE n 
1 118 MET n 
1 119 ALA n 
1 120 PHE n 
1 121 ALA n 
1 122 ASN n 
1 123 SER n 
1 124 PRO n 
1 125 TRP n 
1 126 VAL n 
1 127 VAL n 
1 128 GLN n 
1 129 LEU n 
1 130 PHE n 
1 131 TYR n 
1 132 ALA n 
1 133 PHE n 
1 134 GLN n 
1 135 ASP n 
1 136 ASP n 
1 137 ARG n 
1 138 TYR n 
1 139 LEU n 
1 140 TYR n 
1 141 MET n 
1 142 VAL n 
1 143 MET n 
1 144 GLU n 
1 145 TYR n 
1 146 MET n 
1 147 PRO n 
1 148 GLY n 
1 149 GLY n 
1 150 ASP n 
1 151 LEU n 
1 152 VAL n 
1 153 ASN n 
1 154 LEU n 
1 155 MET n 
1 156 SER n 
1 157 ASN n 
1 158 TYR n 
1 159 ASP n 
1 160 VAL n 
1 161 PRO n 
1 162 GLU n 
1 163 LYS n 
1 164 TRP n 
1 165 ALA n 
1 166 LYS n 
1 167 PHE n 
1 168 TYR n 
1 169 THR n 
1 170 ALA n 
1 171 GLU n 
1 172 VAL n 
1 173 VAL n 
1 174 LEU n 
1 175 ALA n 
1 176 LEU n 
1 177 ASP n 
1 178 ALA n 
1 179 ILE n 
1 180 HIS n 
1 181 SER n 
1 182 MET n 
1 183 GLY n 
1 184 LEU n 
1 185 ILE n 
1 186 HIS n 
1 187 ARG n 
1 188 ASP n 
1 189 VAL n 
1 190 LYS n 
1 191 PRO n 
1 192 ASP n 
1 193 ASN n 
1 194 MET n 
1 195 LEU n 
1 196 LEU n 
1 197 ASP n 
1 198 LYS n 
1 199 HIS n 
1 200 GLY n 
1 201 HIS n 
1 202 LEU n 
1 203 LYS n 
1 204 LEU n 
1 205 ALA n 
1 206 ASP n 
1 207 PHE n 
1 208 GLY n 
1 209 THR n 
1 210 CYS n 
1 211 MET n 
1 212 LYS n 
1 213 MET n 
1 214 ASP n 
1 215 GLU n 
1 216 THR n 
1 217 GLY n 
1 218 MET n 
1 219 VAL n 
1 220 HIS n 
1 221 CYS n 
1 222 ASP n 
1 223 THR n 
1 224 ALA n 
1 225 VAL n 
1 226 GLY n 
1 227 THR n 
1 228 PRO n 
1 229 ASP n 
1 230 TYR n 
1 231 ILE n 
1 232 SER n 
1 233 PRO n 
1 234 GLU n 
1 235 VAL n 
1 236 LEU n 
1 237 LYS n 
1 238 SER n 
1 239 GLN n 
1 240 GLY n 
1 241 GLY n 
1 242 ASP n 
1 243 GLY n 
1 244 PHE n 
1 245 TYR n 
1 246 GLY n 
1 247 ARG n 
1 248 GLU n 
1 249 CYS n 
1 250 ASP n 
1 251 TRP n 
1 252 TRP n 
1 253 SER n 
1 254 VAL n 
1 255 GLY n 
1 256 VAL n 
1 257 PHE n 
1 258 LEU n 
1 259 TYR n 
1 260 GLU n 
1 261 MET n 
1 262 LEU n 
1 263 VAL n 
1 264 GLY n 
1 265 ASP n 
1 266 THR n 
1 267 PRO n 
1 268 PHE n 
1 269 TYR n 
1 270 ALA n 
1 271 ASP n 
1 272 SER n 
1 273 LEU n 
1 274 VAL n 
1 275 GLY n 
1 276 THR n 
1 277 TYR n 
1 278 SER n 
1 279 LYS n 
1 280 ILE n 
1 281 MET n 
1 282 ASP n 
1 283 HIS n 
1 284 LYS n 
1 285 ASN n 
1 286 SER n 
1 287 LEU n 
1 288 CYS n 
1 289 PHE n 
1 290 PRO n 
1 291 GLU n 
1 292 ASP n 
1 293 ALA n 
1 294 GLU n 
1 295 ILE n 
1 296 SER n 
1 297 LYS n 
1 298 HIS n 
1 299 ALA n 
1 300 LYS n 
1 301 ASN n 
1 302 LEU n 
1 303 ILE n 
1 304 CYS n 
1 305 ALA n 
1 306 PHE n 
1 307 LEU n 
1 308 THR n 
1 309 ASP n 
1 310 ARG n 
1 311 GLU n 
1 312 VAL n 
1 313 ARG n 
1 314 LEU n 
1 315 GLY n 
1 316 ARG n 
1 317 ASN n 
1 318 GLY n 
1 319 VAL n 
1 320 GLU n 
1 321 GLU n 
1 322 ILE n 
1 323 ARG n 
1 324 GLN n 
1 325 HIS n 
1 326 PRO n 
1 327 PHE n 
1 328 PHE n 
1 329 LYS n 
1 330 ASN n 
1 331 ASP n 
1 332 GLN n 
1 333 TRP n 
1 334 HIS n 
1 335 TRP n 
1 336 ASP n 
1 337 ASN n 
1 338 ILE n 
1 339 ARG n 
1 340 GLU n 
1 341 THR n 
1 342 ALA n 
1 343 ALA n 
1 344 PRO n 
1 345 VAL n 
1 346 VAL n 
1 347 PRO n 
1 348 GLU n 
1 349 LEU n 
1 350 SER n 
1 351 SER n 
1 352 ASP n 
1 353 ILE n 
1 354 ASP n 
1 355 SER n 
1 356 SER n 
1 357 ASN n 
1 358 PHE n 
1 359 ASP n 
1 360 ASP n 
1 361 ILE n 
1 362 GLU n 
1 363 ASP n 
1 364 ASP n 
1 365 LYS n 
1 366 GLY n 
1 367 ASP n 
1 368 VAL n 
1 369 GLU n 
1 370 THR n 
1 371 PHE n 
1 372 PRO n 
1 373 ILE n 
1 374 PRO n 
1 375 LYS n 
1 376 ALA n 
1 377 PHE n 
1 378 VAL n 
1 379 GLY n 
1 380 ASN n 
1 381 GLN n 
1 382 LEU n 
1 383 PRO n 
1 384 PHE n 
1 385 ILE n 
1 386 GLY n 
1 387 PHE n 
1 388 THR n 
1 389 TYR n 
1 390 TYR n 
1 391 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   391 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'ROCK2, KIAA0619' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                      ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                     ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                   ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                              ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                     ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                    ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                              ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                      ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                    ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                        ? 'H2 O' 
18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                   ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                      ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                       ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                   ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                      ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                       ? 
'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION'                                                                                ? 'O4 S -2' 
96.063  
THR 'L-peptide linking' y THREONINE                                                                                    ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                   ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                     ? 
'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                                                       ? 
'C5 H11 N O2'    117.146 
YEW non-polymer         . '~{N}-methyl-3-[[6-(2-methylpyrazol-3-yl)-1-oxidanylidene-isoquinolin-2-yl]methyl]benzamide' ? 
'C22 H20 N4 O2'  372.420 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLN 1   27  ?   ?   ?   A . n 
A 1 2   ARG 2   28  ?   ?   ?   A . n 
A 1 3   LYS 3   29  29  LYS LYS A . n 
A 1 4   LEU 4   30  30  LEU LEU A . n 
A 1 5   GLU 5   31  31  GLU GLU A . n 
A 1 6   ALA 6   32  32  ALA ALA A . n 
A 1 7   LEU 7   33  33  LEU LEU A . n 
A 1 8   ILE 8   34  34  ILE ILE A . n 
A 1 9   ARG 9   35  35  ARG ARG A . n 
A 1 10  ASP 10  36  36  ASP ASP A . n 
A 1 11  PRO 11  37  37  PRO PRO A . n 
A 1 12  ARG 12  38  38  ARG ARG A . n 
A 1 13  SER 13  39  39  SER SER A . n 
A 1 14  PRO 14  40  40  PRO PRO A . n 
A 1 15  ILE 15  41  41  ILE ILE A . n 
A 1 16  ASN 16  42  42  ASN ASN A . n 
A 1 17  VAL 17  43  43  VAL VAL A . n 
A 1 18  GLU 18  44  44  GLU GLU A . n 
A 1 19  SER 19  45  45  SER SER A . n 
A 1 20  LEU 20  46  46  LEU LEU A . n 
A 1 21  LEU 21  47  47  LEU LEU A . n 
A 1 22  ASP 22  48  48  ASP ASP A . n 
A 1 23  GLY 23  49  49  GLY GLY A . n 
A 1 24  LEU 24  50  50  LEU LEU A . n 
A 1 25  ASN 25  51  51  ASN ASN A . n 
A 1 26  SER 26  52  52  SER SER A . n 
A 1 27  LEU 27  53  53  LEU LEU A . n 
A 1 28  VAL 28  54  54  VAL VAL A . n 
A 1 29  LEU 29  55  55  LEU LEU A . n 
A 1 30  ASP 30  56  56  ASP ASP A . n 
A 1 31  LEU 31  57  57  LEU LEU A . n 
A 1 32  ASP 32  58  58  ASP ASP A . n 
A 1 33  PHE 33  59  59  PHE PHE A . n 
A 1 34  PRO 34  60  60  PRO PRO A . n 
A 1 35  ALA 35  61  61  ALA ALA A . n 
A 1 36  LEU 36  62  62  LEU LEU A . n 
A 1 37  ARG 37  63  63  ARG ARG A . n 
A 1 38  LYS 38  64  64  LYS LYS A . n 
A 1 39  ASN 39  65  65  ASN ASN A . n 
A 1 40  LYS 40  66  66  LYS LYS A . n 
A 1 41  ASN 41  67  67  ASN ASN A . n 
A 1 42  ILE 42  68  68  ILE ILE A . n 
A 1 43  ASP 43  69  69  ASP ASP A . n 
A 1 44  ASN 44  70  70  ASN ASN A . n 
A 1 45  PHE 45  71  71  PHE PHE A . n 
A 1 46  LEU 46  72  72  LEU LEU A . n 
A 1 47  ASN 47  73  73  ASN ASN A . n 
A 1 48  ARG 48  74  74  ARG ARG A . n 
A 1 49  TYR 49  75  75  TYR TYR A . n 
A 1 50  GLU 50  76  76  GLU GLU A . n 
A 1 51  LYS 51  77  77  LYS LYS A . n 
A 1 52  ILE 52  78  78  ILE ILE A . n 
A 1 53  VAL 53  79  79  VAL VAL A . n 
A 1 54  LYS 54  80  80  LYS LYS A . n 
A 1 55  LYS 55  81  81  LYS LYS A . n 
A 1 56  ILE 56  82  82  ILE ILE A . n 
A 1 57  ARG 57  83  83  ARG ARG A . n 
A 1 58  GLY 58  84  84  GLY GLY A . n 
A 1 59  LEU 59  85  85  LEU LEU A . n 
A 1 60  GLN 60  86  86  GLN GLN A . n 
A 1 61  MET 61  87  87  MET MET A . n 
A 1 62  LYS 62  88  88  LYS LYS A . n 
A 1 63  ALA 63  89  89  ALA ALA A . n 
A 1 64  GLU 64  90  90  GLU GLU A . n 
A 1 65  ASP 65  91  91  ASP ASP A . n 
A 1 66  TYR 66  92  92  TYR TYR A . n 
A 1 67  ASP 67  93  93  ASP ASP A . n 
A 1 68  VAL 68  94  94  VAL VAL A . n 
A 1 69  VAL 69  95  95  VAL VAL A . n 
A 1 70  LYS 70  96  96  LYS LYS A . n 
A 1 71  VAL 71  97  97  VAL VAL A . n 
A 1 72  ILE 72  98  98  ILE ILE A . n 
A 1 73  GLY 73  99  99  GLY GLY A . n 
A 1 74  ARG 74  100 100 ARG ARG A . n 
A 1 75  GLY 75  101 101 GLY GLY A . n 
A 1 76  ALA 76  102 102 ALA ALA A . n 
A 1 77  PHE 77  103 103 PHE PHE A . n 
A 1 78  GLY 78  104 104 GLY GLY A . n 
A 1 79  GLU 79  105 105 GLU GLU A . n 
A 1 80  VAL 80  106 106 VAL VAL A . n 
A 1 81  GLN 81  107 107 GLN GLN A . n 
A 1 82  LEU 82  108 108 LEU LEU A . n 
A 1 83  VAL 83  109 109 VAL VAL A . n 
A 1 84  ARG 84  110 110 ARG ARG A . n 
A 1 85  HIS 85  111 111 HIS HIS A . n 
A 1 86  LYS 86  112 112 LYS LYS A . n 
A 1 87  ALA 87  113 113 ALA ALA A . n 
A 1 88  SER 88  114 114 SER SER A . n 
A 1 89  GLN 89  115 115 GLN GLN A . n 
A 1 90  LYS 90  116 116 LYS LYS A . n 
A 1 91  VAL 91  117 117 VAL VAL A . n 
A 1 92  TYR 92  118 118 TYR TYR A . n 
A 1 93  ALA 93  119 119 ALA ALA A . n 
A 1 94  MET 94  120 120 MET MET A . n 
A 1 95  LYS 95  121 121 LYS LYS A . n 
A 1 96  LEU 96  122 122 LEU LEU A . n 
A 1 97  LEU 97  123 123 LEU LEU A . n 
A 1 98  SER 98  124 124 SER SER A . n 
A 1 99  LYS 99  125 125 LYS LYS A . n 
A 1 100 PHE 100 126 126 PHE PHE A . n 
A 1 101 GLU 101 127 127 GLU GLU A . n 
A 1 102 MET 102 128 128 MET MET A . n 
A 1 103 ILE 103 129 129 ILE ILE A . n 
A 1 104 LYS 104 130 130 LYS LYS A . n 
A 1 105 ARG 105 131 131 ARG ARG A . n 
A 1 106 SER 106 132 132 SER SER A . n 
A 1 107 ASP 107 133 133 ASP ASP A . n 
A 1 108 SER 108 134 134 SER SER A . n 
A 1 109 ALA 109 135 135 ALA ALA A . n 
A 1 110 PHE 110 136 136 PHE PHE A . n 
A 1 111 PHE 111 137 137 PHE PHE A . n 
A 1 112 TRP 112 138 138 TRP TRP A . n 
A 1 113 GLU 113 139 139 GLU GLU A . n 
A 1 114 GLU 114 140 140 GLU GLU A . n 
A 1 115 ARG 115 141 141 ARG ARG A . n 
A 1 116 ASP 116 142 142 ASP ASP A . n 
A 1 117 ILE 117 143 143 ILE ILE A . n 
A 1 118 MET 118 144 144 MET MET A . n 
A 1 119 ALA 119 145 145 ALA ALA A . n 
A 1 120 PHE 120 146 146 PHE PHE A . n 
A 1 121 ALA 121 147 147 ALA ALA A . n 
A 1 122 ASN 122 148 148 ASN ASN A . n 
A 1 123 SER 123 149 149 SER SER A . n 
A 1 124 PRO 124 150 150 PRO PRO A . n 
A 1 125 TRP 125 151 151 TRP TRP A . n 
A 1 126 VAL 126 152 152 VAL VAL A . n 
A 1 127 VAL 127 153 153 VAL VAL A . n 
A 1 128 GLN 128 154 154 GLN GLN A . n 
A 1 129 LEU 129 155 155 LEU LEU A . n 
A 1 130 PHE 130 156 156 PHE PHE A . n 
A 1 131 TYR 131 157 157 TYR TYR A . n 
A 1 132 ALA 132 158 158 ALA ALA A . n 
A 1 133 PHE 133 159 159 PHE PHE A . n 
A 1 134 GLN 134 160 160 GLN GLN A . n 
A 1 135 ASP 135 161 161 ASP ASP A . n 
A 1 136 ASP 136 162 162 ASP ASP A . n 
A 1 137 ARG 137 163 163 ARG ARG A . n 
A 1 138 TYR 138 164 164 TYR TYR A . n 
A 1 139 LEU 139 165 165 LEU LEU A . n 
A 1 140 TYR 140 166 166 TYR TYR A . n 
A 1 141 MET 141 167 167 MET MET A . n 
A 1 142 VAL 142 168 168 VAL VAL A . n 
A 1 143 MET 143 169 169 MET MET A . n 
A 1 144 GLU 144 170 170 GLU GLU A . n 
A 1 145 TYR 145 171 171 TYR TYR A . n 
A 1 146 MET 146 172 172 MET MET A . n 
A 1 147 PRO 147 173 173 PRO PRO A . n 
A 1 148 GLY 148 174 174 GLY GLY A . n 
A 1 149 GLY 149 175 175 GLY GLY A . n 
A 1 150 ASP 150 176 176 ASP ASP A . n 
A 1 151 LEU 151 177 177 LEU LEU A . n 
A 1 152 VAL 152 178 178 VAL VAL A . n 
A 1 153 ASN 153 179 179 ASN ASN A . n 
A 1 154 LEU 154 180 180 LEU LEU A . n 
A 1 155 MET 155 181 181 MET MET A . n 
A 1 156 SER 156 182 182 SER SER A . n 
A 1 157 ASN 157 183 183 ASN ASN A . n 
A 1 158 TYR 158 184 184 TYR TYR A . n 
A 1 159 ASP 159 185 185 ASP ASP A . n 
A 1 160 VAL 160 186 186 VAL VAL A . n 
A 1 161 PRO 161 187 187 PRO PRO A . n 
A 1 162 GLU 162 188 188 GLU GLU A . n 
A 1 163 LYS 163 189 189 LYS LYS A . n 
A 1 164 TRP 164 190 190 TRP TRP A . n 
A 1 165 ALA 165 191 191 ALA ALA A . n 
A 1 166 LYS 166 192 192 LYS LYS A . n 
A 1 167 PHE 167 193 193 PHE PHE A . n 
A 1 168 TYR 168 194 194 TYR TYR A . n 
A 1 169 THR 169 195 195 THR THR A . n 
A 1 170 ALA 170 196 196 ALA ALA A . n 
A 1 171 GLU 171 197 197 GLU GLU A . n 
A 1 172 VAL 172 198 198 VAL VAL A . n 
A 1 173 VAL 173 199 199 VAL VAL A . n 
A 1 174 LEU 174 200 200 LEU LEU A . n 
A 1 175 ALA 175 201 201 ALA ALA A . n 
A 1 176 LEU 176 202 202 LEU LEU A . n 
A 1 177 ASP 177 203 203 ASP ASP A . n 
A 1 178 ALA 178 204 204 ALA ALA A . n 
A 1 179 ILE 179 205 205 ILE ILE A . n 
A 1 180 HIS 180 206 206 HIS HIS A . n 
A 1 181 SER 181 207 207 SER SER A . n 
A 1 182 MET 182 208 208 MET MET A . n 
A 1 183 GLY 183 209 209 GLY GLY A . n 
A 1 184 LEU 184 210 210 LEU LEU A . n 
A 1 185 ILE 185 211 211 ILE ILE A . n 
A 1 186 HIS 186 212 212 HIS HIS A . n 
A 1 187 ARG 187 213 213 ARG ARG A . n 
A 1 188 ASP 188 214 214 ASP ASP A . n 
A 1 189 VAL 189 215 215 VAL VAL A . n 
A 1 190 LYS 190 216 216 LYS LYS A . n 
A 1 191 PRO 191 217 217 PRO PRO A . n 
A 1 192 ASP 192 218 218 ASP ASP A . n 
A 1 193 ASN 193 219 219 ASN ASN A . n 
A 1 194 MET 194 220 220 MET MET A . n 
A 1 195 LEU 195 221 221 LEU LEU A . n 
A 1 196 LEU 196 222 222 LEU LEU A . n 
A 1 197 ASP 197 223 223 ASP ASP A . n 
A 1 198 LYS 198 224 224 LYS LYS A . n 
A 1 199 HIS 199 225 225 HIS HIS A . n 
A 1 200 GLY 200 226 226 GLY GLY A . n 
A 1 201 HIS 201 227 227 HIS HIS A . n 
A 1 202 LEU 202 228 228 LEU LEU A . n 
A 1 203 LYS 203 229 229 LYS LYS A . n 
A 1 204 LEU 204 230 230 LEU LEU A . n 
A 1 205 ALA 205 231 231 ALA ALA A . n 
A 1 206 ASP 206 232 232 ASP ASP A . n 
A 1 207 PHE 207 233 233 PHE PHE A . n 
A 1 208 GLY 208 234 234 GLY GLY A . n 
A 1 209 THR 209 235 235 THR THR A . n 
A 1 210 CYS 210 236 236 CYS CYS A . n 
A 1 211 MET 211 237 237 MET MET A . n 
A 1 212 LYS 212 238 238 LYS LYS A . n 
A 1 213 MET 213 239 239 MET MET A . n 
A 1 214 ASP 214 240 240 ASP ASP A . n 
A 1 215 GLU 215 241 241 GLU GLU A . n 
A 1 216 THR 216 242 242 THR THR A . n 
A 1 217 GLY 217 243 243 GLY GLY A . n 
A 1 218 MET 218 244 244 MET MET A . n 
A 1 219 VAL 219 245 245 VAL VAL A . n 
A 1 220 HIS 220 246 246 HIS HIS A . n 
A 1 221 CYS 221 247 247 CYS CYS A . n 
A 1 222 ASP 222 248 248 ASP ASP A . n 
A 1 223 THR 223 249 249 THR THR A . n 
A 1 224 ALA 224 250 250 ALA ALA A . n 
A 1 225 VAL 225 251 251 VAL VAL A . n 
A 1 226 GLY 226 252 252 GLY GLY A . n 
A 1 227 THR 227 253 253 THR THR A . n 
A 1 228 PRO 228 254 254 PRO PRO A . n 
A 1 229 ASP 229 255 255 ASP ASP A . n 
A 1 230 TYR 230 256 256 TYR TYR A . n 
A 1 231 ILE 231 257 257 ILE ILE A . n 
A 1 232 SER 232 258 258 SER SER A . n 
A 1 233 PRO 233 259 259 PRO PRO A . n 
A 1 234 GLU 234 260 260 GLU GLU A . n 
A 1 235 VAL 235 261 261 VAL VAL A . n 
A 1 236 LEU 236 262 262 LEU LEU A . n 
A 1 237 LYS 237 263 263 LYS LYS A . n 
A 1 238 SER 238 264 264 SER SER A . n 
A 1 239 GLN 239 265 265 GLN GLN A . n 
A 1 240 GLY 240 266 266 GLY GLY A . n 
A 1 241 GLY 241 267 267 GLY GLY A . n 
A 1 242 ASP 242 268 268 ASP ASP A . n 
A 1 243 GLY 243 269 269 GLY GLY A . n 
A 1 244 PHE 244 270 270 PHE PHE A . n 
A 1 245 TYR 245 271 271 TYR TYR A . n 
A 1 246 GLY 246 272 272 GLY GLY A . n 
A 1 247 ARG 247 273 273 ARG ARG A . n 
A 1 248 GLU 248 274 274 GLU GLU A . n 
A 1 249 CYS 249 275 275 CYS CYS A . n 
A 1 250 ASP 250 276 276 ASP ASP A . n 
A 1 251 TRP 251 277 277 TRP TRP A . n 
A 1 252 TRP 252 278 278 TRP TRP A . n 
A 1 253 SER 253 279 279 SER SER A . n 
A 1 254 VAL 254 280 280 VAL VAL A . n 
A 1 255 GLY 255 281 281 GLY GLY A . n 
A 1 256 VAL 256 282 282 VAL VAL A . n 
A 1 257 PHE 257 283 283 PHE PHE A . n 
A 1 258 LEU 258 284 284 LEU LEU A . n 
A 1 259 TYR 259 285 285 TYR TYR A . n 
A 1 260 GLU 260 286 286 GLU GLU A . n 
A 1 261 MET 261 287 287 MET MET A . n 
A 1 262 LEU 262 288 288 LEU LEU A . n 
A 1 263 VAL 263 289 289 VAL VAL A . n 
A 1 264 GLY 264 290 290 GLY GLY A . n 
A 1 265 ASP 265 291 291 ASP ASP A . n 
A 1 266 THR 266 292 292 THR THR A . n 
A 1 267 PRO 267 293 293 PRO PRO A . n 
A 1 268 PHE 268 294 294 PHE PHE A . n 
A 1 269 TYR 269 295 295 TYR TYR A . n 
A 1 270 ALA 270 296 296 ALA ALA A . n 
A 1 271 ASP 271 297 297 ASP ASP A . n 
A 1 272 SER 272 298 298 SER SER A . n 
A 1 273 LEU 273 299 299 LEU LEU A . n 
A 1 274 VAL 274 300 300 VAL VAL A . n 
A 1 275 GLY 275 301 301 GLY GLY A . n 
A 1 276 THR 276 302 302 THR THR A . n 
A 1 277 TYR 277 303 303 TYR TYR A . n 
A 1 278 SER 278 304 304 SER SER A . n 
A 1 279 LYS 279 305 305 LYS LYS A . n 
A 1 280 ILE 280 306 306 ILE ILE A . n 
A 1 281 MET 281 307 307 MET MET A . n 
A 1 282 ASP 282 308 308 ASP ASP A . n 
A 1 283 HIS 283 309 309 HIS HIS A . n 
A 1 284 LYS 284 310 310 LYS LYS A . n 
A 1 285 ASN 285 311 311 ASN ASN A . n 
A 1 286 SER 286 312 312 SER SER A . n 
A 1 287 LEU 287 313 313 LEU LEU A . n 
A 1 288 CYS 288 314 314 CYS CYS A . n 
A 1 289 PHE 289 315 315 PHE PHE A . n 
A 1 290 PRO 290 316 316 PRO PRO A . n 
A 1 291 GLU 291 317 317 GLU GLU A . n 
A 1 292 ASP 292 318 318 ASP ASP A . n 
A 1 293 ALA 293 319 319 ALA ALA A . n 
A 1 294 GLU 294 320 320 GLU GLU A . n 
A 1 295 ILE 295 321 321 ILE ILE A . n 
A 1 296 SER 296 322 322 SER SER A . n 
A 1 297 LYS 297 323 323 LYS LYS A . n 
A 1 298 HIS 298 324 324 HIS HIS A . n 
A 1 299 ALA 299 325 325 ALA ALA A . n 
A 1 300 LYS 300 326 326 LYS LYS A . n 
A 1 301 ASN 301 327 327 ASN ASN A . n 
A 1 302 LEU 302 328 328 LEU LEU A . n 
A 1 303 ILE 303 329 329 ILE ILE A . n 
A 1 304 CYS 304 330 330 CYS CYS A . n 
A 1 305 ALA 305 331 331 ALA ALA A . n 
A 1 306 PHE 306 332 332 PHE PHE A . n 
A 1 307 LEU 307 333 333 LEU LEU A . n 
A 1 308 THR 308 334 334 THR THR A . n 
A 1 309 ASP 309 335 335 ASP ASP A . n 
A 1 310 ARG 310 336 336 ARG ARG A . n 
A 1 311 GLU 311 337 337 GLU GLU A . n 
A 1 312 VAL 312 338 338 VAL VAL A . n 
A 1 313 ARG 313 339 339 ARG ARG A . n 
A 1 314 LEU 314 340 340 LEU LEU A . n 
A 1 315 GLY 315 341 341 GLY GLY A . n 
A 1 316 ARG 316 342 342 ARG ARG A . n 
A 1 317 ASN 317 343 343 ASN ASN A . n 
A 1 318 GLY 318 344 344 GLY GLY A . n 
A 1 319 VAL 319 345 345 VAL VAL A . n 
A 1 320 GLU 320 346 346 GLU GLU A . n 
A 1 321 GLU 321 347 347 GLU GLU A . n 
A 1 322 ILE 322 348 348 ILE ILE A . n 
A 1 323 ARG 323 349 349 ARG ARG A . n 
A 1 324 GLN 324 350 350 GLN GLN A . n 
A 1 325 HIS 325 351 351 HIS HIS A . n 
A 1 326 PRO 326 352 352 PRO PRO A . n 
A 1 327 PHE 327 353 353 PHE PHE A . n 
A 1 328 PHE 328 354 354 PHE PHE A . n 
A 1 329 LYS 329 355 355 LYS LYS A . n 
A 1 330 ASN 330 356 356 ASN ASN A . n 
A 1 331 ASP 331 357 357 ASP ASP A . n 
A 1 332 GLN 332 358 358 GLN GLN A . n 
A 1 333 TRP 333 359 359 TRP TRP A . n 
A 1 334 HIS 334 360 360 HIS HIS A . n 
A 1 335 TRP 335 361 361 TRP TRP A . n 
A 1 336 ASP 336 362 362 ASP ASP A . n 
A 1 337 ASN 337 363 363 ASN ASN A . n 
A 1 338 ILE 338 364 364 ILE ILE A . n 
A 1 339 ARG 339 365 365 ARG ARG A . n 
A 1 340 GLU 340 366 366 GLU GLU A . n 
A 1 341 THR 341 367 367 THR THR A . n 
A 1 342 ALA 342 368 368 ALA ALA A . n 
A 1 343 ALA 343 369 369 ALA ALA A . n 
A 1 344 PRO 344 370 370 PRO PRO A . n 
A 1 345 VAL 345 371 371 VAL VAL A . n 
A 1 346 VAL 346 372 372 VAL VAL A . n 
A 1 347 PRO 347 373 373 PRO PRO A . n 
A 1 348 GLU 348 374 374 GLU GLU A . n 
A 1 349 LEU 349 375 375 LEU LEU A . n 
A 1 350 SER 350 376 376 SER SER A . n 
A 1 351 SER 351 377 377 SER SER A . n 
A 1 352 ASP 352 378 378 ASP ASP A . n 
A 1 353 ILE 353 379 379 ILE ILE A . n 
A 1 354 ASP 354 380 380 ASP ASP A . n 
A 1 355 SER 355 381 381 SER SER A . n 
A 1 356 SER 356 382 382 SER SER A . n 
A 1 357 ASN 357 383 383 ASN ASN A . n 
A 1 358 PHE 358 384 384 PHE PHE A . n 
A 1 359 ASP 359 385 385 ASP ASP A . n 
A 1 360 ASP 360 386 386 ASP ASP A . n 
A 1 361 ILE 361 387 387 ILE ILE A . n 
A 1 362 GLU 362 388 388 GLU GLU A . n 
A 1 363 ASP 363 389 389 ASP ASP A . n 
A 1 364 ASP 364 390 ?   ?   ?   A . n 
A 1 365 LYS 365 391 ?   ?   ?   A . n 
A 1 366 GLY 366 392 ?   ?   ?   A . n 
A 1 367 ASP 367 393 ?   ?   ?   A . n 
A 1 368 VAL 368 394 394 VAL VAL A . n 
A 1 369 GLU 369 395 395 GLU GLU A . n 
A 1 370 THR 370 396 396 THR THR A . n 
A 1 371 PHE 371 397 397 PHE PHE A . n 
A 1 372 PRO 372 398 398 PRO PRO A . n 
A 1 373 ILE 373 399 399 ILE ILE A . n 
A 1 374 PRO 374 400 400 PRO PRO A . n 
A 1 375 LYS 375 401 401 LYS LYS A . n 
A 1 376 ALA 376 402 402 ALA ALA A . n 
A 1 377 PHE 377 403 403 PHE PHE A . n 
A 1 378 VAL 378 404 404 VAL VAL A . n 
A 1 379 GLY 379 405 405 GLY GLY A . n 
A 1 380 ASN 380 406 406 ASN ASN A . n 
A 1 381 GLN 381 407 407 GLN GLN A . n 
A 1 382 LEU 382 408 408 LEU LEU A . n 
A 1 383 PRO 383 409 409 PRO PRO A . n 
A 1 384 PHE 384 410 410 PHE PHE A . n 
A 1 385 ILE 385 411 411 ILE ILE A . n 
A 1 386 GLY 386 412 412 GLY GLY A . n 
A 1 387 PHE 387 413 413 PHE PHE A . n 
A 1 388 THR 388 414 414 THR THR A . n 
A 1 389 TYR 389 415 415 TYR TYR A . n 
A 1 390 TYR 390 416 416 TYR TYR A . n 
A 1 391 ARG 391 417 ?   ?   ?   A . n 
B 1 1   GLN 1   27  ?   ?   ?   B . n 
B 1 2   ARG 2   28  ?   ?   ?   B . n 
B 1 3   LYS 3   29  29  LYS LYS B . n 
B 1 4   LEU 4   30  30  LEU LEU B . n 
B 1 5   GLU 5   31  31  GLU GLU B . n 
B 1 6   ALA 6   32  32  ALA ALA B . n 
B 1 7   LEU 7   33  33  LEU LEU B . n 
B 1 8   ILE 8   34  34  ILE ILE B . n 
B 1 9   ARG 9   35  35  ARG ARG B . n 
B 1 10  ASP 10  36  36  ASP ASP B . n 
B 1 11  PRO 11  37  37  PRO PRO B . n 
B 1 12  ARG 12  38  38  ARG ARG B . n 
B 1 13  SER 13  39  39  SER SER B . n 
B 1 14  PRO 14  40  40  PRO PRO B . n 
B 1 15  ILE 15  41  41  ILE ILE B . n 
B 1 16  ASN 16  42  42  ASN ASN B . n 
B 1 17  VAL 17  43  43  VAL VAL B . n 
B 1 18  GLU 18  44  44  GLU GLU B . n 
B 1 19  SER 19  45  45  SER SER B . n 
B 1 20  LEU 20  46  46  LEU LEU B . n 
B 1 21  LEU 21  47  47  LEU LEU B . n 
B 1 22  ASP 22  48  48  ASP ASP B . n 
B 1 23  GLY 23  49  49  GLY GLY B . n 
B 1 24  LEU 24  50  50  LEU LEU B . n 
B 1 25  ASN 25  51  51  ASN ASN B . n 
B 1 26  SER 26  52  52  SER SER B . n 
B 1 27  LEU 27  53  53  LEU LEU B . n 
B 1 28  VAL 28  54  54  VAL VAL B . n 
B 1 29  LEU 29  55  55  LEU LEU B . n 
B 1 30  ASP 30  56  56  ASP ASP B . n 
B 1 31  LEU 31  57  57  LEU LEU B . n 
B 1 32  ASP 32  58  58  ASP ASP B . n 
B 1 33  PHE 33  59  59  PHE PHE B . n 
B 1 34  PRO 34  60  60  PRO PRO B . n 
B 1 35  ALA 35  61  61  ALA ALA B . n 
B 1 36  LEU 36  62  62  LEU LEU B . n 
B 1 37  ARG 37  63  63  ARG ARG B . n 
B 1 38  LYS 38  64  64  LYS LYS B . n 
B 1 39  ASN 39  65  65  ASN ASN B . n 
B 1 40  LYS 40  66  66  LYS LYS B . n 
B 1 41  ASN 41  67  67  ASN ASN B . n 
B 1 42  ILE 42  68  68  ILE ILE B . n 
B 1 43  ASP 43  69  69  ASP ASP B . n 
B 1 44  ASN 44  70  70  ASN ASN B . n 
B 1 45  PHE 45  71  71  PHE PHE B . n 
B 1 46  LEU 46  72  72  LEU LEU B . n 
B 1 47  ASN 47  73  73  ASN ASN B . n 
B 1 48  ARG 48  74  74  ARG ARG B . n 
B 1 49  TYR 49  75  75  TYR TYR B . n 
B 1 50  GLU 50  76  76  GLU GLU B . n 
B 1 51  LYS 51  77  77  LYS LYS B . n 
B 1 52  ILE 52  78  78  ILE ILE B . n 
B 1 53  VAL 53  79  79  VAL VAL B . n 
B 1 54  LYS 54  80  80  LYS LYS B . n 
B 1 55  LYS 55  81  81  LYS LYS B . n 
B 1 56  ILE 56  82  82  ILE ILE B . n 
B 1 57  ARG 57  83  83  ARG ARG B . n 
B 1 58  GLY 58  84  84  GLY GLY B . n 
B 1 59  LEU 59  85  85  LEU LEU B . n 
B 1 60  GLN 60  86  86  GLN GLN B . n 
B 1 61  MET 61  87  87  MET MET B . n 
B 1 62  LYS 62  88  88  LYS LYS B . n 
B 1 63  ALA 63  89  89  ALA ALA B . n 
B 1 64  GLU 64  90  90  GLU GLU B . n 
B 1 65  ASP 65  91  91  ASP ASP B . n 
B 1 66  TYR 66  92  92  TYR TYR B . n 
B 1 67  ASP 67  93  93  ASP ASP B . n 
B 1 68  VAL 68  94  94  VAL VAL B . n 
B 1 69  VAL 69  95  95  VAL VAL B . n 
B 1 70  LYS 70  96  96  LYS LYS B . n 
B 1 71  VAL 71  97  97  VAL VAL B . n 
B 1 72  ILE 72  98  98  ILE ILE B . n 
B 1 73  GLY 73  99  99  GLY GLY B . n 
B 1 74  ARG 74  100 100 ARG ARG B . n 
B 1 75  GLY 75  101 101 GLY GLY B . n 
B 1 76  ALA 76  102 102 ALA ALA B . n 
B 1 77  PHE 77  103 103 PHE PHE B . n 
B 1 78  GLY 78  104 104 GLY GLY B . n 
B 1 79  GLU 79  105 105 GLU GLU B . n 
B 1 80  VAL 80  106 106 VAL VAL B . n 
B 1 81  GLN 81  107 107 GLN GLN B . n 
B 1 82  LEU 82  108 108 LEU LEU B . n 
B 1 83  VAL 83  109 109 VAL VAL B . n 
B 1 84  ARG 84  110 110 ARG ARG B . n 
B 1 85  HIS 85  111 111 HIS HIS B . n 
B 1 86  LYS 86  112 112 LYS LYS B . n 
B 1 87  ALA 87  113 113 ALA ALA B . n 
B 1 88  SER 88  114 114 SER SER B . n 
B 1 89  GLN 89  115 115 GLN GLN B . n 
B 1 90  LYS 90  116 116 LYS LYS B . n 
B 1 91  VAL 91  117 117 VAL VAL B . n 
B 1 92  TYR 92  118 118 TYR TYR B . n 
B 1 93  ALA 93  119 119 ALA ALA B . n 
B 1 94  MET 94  120 120 MET MET B . n 
B 1 95  LYS 95  121 121 LYS LYS B . n 
B 1 96  LEU 96  122 122 LEU LEU B . n 
B 1 97  LEU 97  123 123 LEU LEU B . n 
B 1 98  SER 98  124 124 SER SER B . n 
B 1 99  LYS 99  125 125 LYS LYS B . n 
B 1 100 PHE 100 126 126 PHE PHE B . n 
B 1 101 GLU 101 127 127 GLU GLU B . n 
B 1 102 MET 102 128 128 MET MET B . n 
B 1 103 ILE 103 129 129 ILE ILE B . n 
B 1 104 LYS 104 130 130 LYS LYS B . n 
B 1 105 ARG 105 131 131 ARG ARG B . n 
B 1 106 SER 106 132 132 SER SER B . n 
B 1 107 ASP 107 133 133 ASP ASP B . n 
B 1 108 SER 108 134 134 SER SER B . n 
B 1 109 ALA 109 135 135 ALA ALA B . n 
B 1 110 PHE 110 136 136 PHE PHE B . n 
B 1 111 PHE 111 137 137 PHE PHE B . n 
B 1 112 TRP 112 138 138 TRP TRP B . n 
B 1 113 GLU 113 139 139 GLU GLU B . n 
B 1 114 GLU 114 140 140 GLU GLU B . n 
B 1 115 ARG 115 141 141 ARG ARG B . n 
B 1 116 ASP 116 142 142 ASP ASP B . n 
B 1 117 ILE 117 143 143 ILE ILE B . n 
B 1 118 MET 118 144 144 MET MET B . n 
B 1 119 ALA 119 145 145 ALA ALA B . n 
B 1 120 PHE 120 146 146 PHE PHE B . n 
B 1 121 ALA 121 147 147 ALA ALA B . n 
B 1 122 ASN 122 148 148 ASN ASN B . n 
B 1 123 SER 123 149 149 SER SER B . n 
B 1 124 PRO 124 150 150 PRO PRO B . n 
B 1 125 TRP 125 151 151 TRP TRP B . n 
B 1 126 VAL 126 152 152 VAL VAL B . n 
B 1 127 VAL 127 153 153 VAL VAL B . n 
B 1 128 GLN 128 154 154 GLN GLN B . n 
B 1 129 LEU 129 155 155 LEU LEU B . n 
B 1 130 PHE 130 156 156 PHE PHE B . n 
B 1 131 TYR 131 157 157 TYR TYR B . n 
B 1 132 ALA 132 158 158 ALA ALA B . n 
B 1 133 PHE 133 159 159 PHE PHE B . n 
B 1 134 GLN 134 160 160 GLN GLN B . n 
B 1 135 ASP 135 161 161 ASP ASP B . n 
B 1 136 ASP 136 162 162 ASP ASP B . n 
B 1 137 ARG 137 163 163 ARG ARG B . n 
B 1 138 TYR 138 164 164 TYR TYR B . n 
B 1 139 LEU 139 165 165 LEU LEU B . n 
B 1 140 TYR 140 166 166 TYR TYR B . n 
B 1 141 MET 141 167 167 MET MET B . n 
B 1 142 VAL 142 168 168 VAL VAL B . n 
B 1 143 MET 143 169 169 MET MET B . n 
B 1 144 GLU 144 170 170 GLU GLU B . n 
B 1 145 TYR 145 171 171 TYR TYR B . n 
B 1 146 MET 146 172 172 MET MET B . n 
B 1 147 PRO 147 173 173 PRO PRO B . n 
B 1 148 GLY 148 174 174 GLY GLY B . n 
B 1 149 GLY 149 175 175 GLY GLY B . n 
B 1 150 ASP 150 176 176 ASP ASP B . n 
B 1 151 LEU 151 177 177 LEU LEU B . n 
B 1 152 VAL 152 178 178 VAL VAL B . n 
B 1 153 ASN 153 179 179 ASN ASN B . n 
B 1 154 LEU 154 180 180 LEU LEU B . n 
B 1 155 MET 155 181 181 MET MET B . n 
B 1 156 SER 156 182 182 SER SER B . n 
B 1 157 ASN 157 183 183 ASN ASN B . n 
B 1 158 TYR 158 184 184 TYR TYR B . n 
B 1 159 ASP 159 185 185 ASP ASP B . n 
B 1 160 VAL 160 186 186 VAL VAL B . n 
B 1 161 PRO 161 187 187 PRO PRO B . n 
B 1 162 GLU 162 188 188 GLU GLU B . n 
B 1 163 LYS 163 189 189 LYS LYS B . n 
B 1 164 TRP 164 190 190 TRP TRP B . n 
B 1 165 ALA 165 191 191 ALA ALA B . n 
B 1 166 LYS 166 192 192 LYS LYS B . n 
B 1 167 PHE 167 193 193 PHE PHE B . n 
B 1 168 TYR 168 194 194 TYR TYR B . n 
B 1 169 THR 169 195 195 THR THR B . n 
B 1 170 ALA 170 196 196 ALA ALA B . n 
B 1 171 GLU 171 197 197 GLU GLU B . n 
B 1 172 VAL 172 198 198 VAL VAL B . n 
B 1 173 VAL 173 199 199 VAL VAL B . n 
B 1 174 LEU 174 200 200 LEU LEU B . n 
B 1 175 ALA 175 201 201 ALA ALA B . n 
B 1 176 LEU 176 202 202 LEU LEU B . n 
B 1 177 ASP 177 203 203 ASP ASP B . n 
B 1 178 ALA 178 204 204 ALA ALA B . n 
B 1 179 ILE 179 205 205 ILE ILE B . n 
B 1 180 HIS 180 206 206 HIS HIS B . n 
B 1 181 SER 181 207 207 SER SER B . n 
B 1 182 MET 182 208 208 MET MET B . n 
B 1 183 GLY 183 209 209 GLY GLY B . n 
B 1 184 LEU 184 210 210 LEU LEU B . n 
B 1 185 ILE 185 211 211 ILE ILE B . n 
B 1 186 HIS 186 212 212 HIS HIS B . n 
B 1 187 ARG 187 213 213 ARG ARG B . n 
B 1 188 ASP 188 214 214 ASP ASP B . n 
B 1 189 VAL 189 215 215 VAL VAL B . n 
B 1 190 LYS 190 216 216 LYS LYS B . n 
B 1 191 PRO 191 217 217 PRO PRO B . n 
B 1 192 ASP 192 218 218 ASP ASP B . n 
B 1 193 ASN 193 219 219 ASN ASN B . n 
B 1 194 MET 194 220 220 MET MET B . n 
B 1 195 LEU 195 221 221 LEU LEU B . n 
B 1 196 LEU 196 222 222 LEU LEU B . n 
B 1 197 ASP 197 223 223 ASP ASP B . n 
B 1 198 LYS 198 224 224 LYS LYS B . n 
B 1 199 HIS 199 225 225 HIS HIS B . n 
B 1 200 GLY 200 226 226 GLY GLY B . n 
B 1 201 HIS 201 227 227 HIS HIS B . n 
B 1 202 LEU 202 228 228 LEU LEU B . n 
B 1 203 LYS 203 229 229 LYS LYS B . n 
B 1 204 LEU 204 230 230 LEU LEU B . n 
B 1 205 ALA 205 231 231 ALA ALA B . n 
B 1 206 ASP 206 232 232 ASP ASP B . n 
B 1 207 PHE 207 233 233 PHE PHE B . n 
B 1 208 GLY 208 234 234 GLY GLY B . n 
B 1 209 THR 209 235 235 THR THR B . n 
B 1 210 CYS 210 236 236 CYS CYS B . n 
B 1 211 MET 211 237 237 MET MET B . n 
B 1 212 LYS 212 238 238 LYS LYS B . n 
B 1 213 MET 213 239 239 MET MET B . n 
B 1 214 ASP 214 240 ?   ?   ?   B . n 
B 1 215 GLU 215 241 ?   ?   ?   B . n 
B 1 216 THR 216 242 ?   ?   ?   B . n 
B 1 217 GLY 217 243 ?   ?   ?   B . n 
B 1 218 MET 218 244 ?   ?   ?   B . n 
B 1 219 VAL 219 245 ?   ?   ?   B . n 
B 1 220 HIS 220 246 ?   ?   ?   B . n 
B 1 221 CYS 221 247 ?   ?   ?   B . n 
B 1 222 ASP 222 248 ?   ?   ?   B . n 
B 1 223 THR 223 249 ?   ?   ?   B . n 
B 1 224 ALA 224 250 250 ALA ALA B . n 
B 1 225 VAL 225 251 251 VAL VAL B . n 
B 1 226 GLY 226 252 252 GLY GLY B . n 
B 1 227 THR 227 253 253 THR THR B . n 
B 1 228 PRO 228 254 254 PRO PRO B . n 
B 1 229 ASP 229 255 255 ASP ASP B . n 
B 1 230 TYR 230 256 256 TYR TYR B . n 
B 1 231 ILE 231 257 257 ILE ILE B . n 
B 1 232 SER 232 258 258 SER SER B . n 
B 1 233 PRO 233 259 259 PRO PRO B . n 
B 1 234 GLU 234 260 260 GLU GLU B . n 
B 1 235 VAL 235 261 261 VAL VAL B . n 
B 1 236 LEU 236 262 262 LEU LEU B . n 
B 1 237 LYS 237 263 263 LYS LYS B . n 
B 1 238 SER 238 264 264 SER SER B . n 
B 1 239 GLN 239 265 265 GLN GLN B . n 
B 1 240 GLY 240 266 ?   ?   ?   B . n 
B 1 241 GLY 241 267 ?   ?   ?   B . n 
B 1 242 ASP 242 268 ?   ?   ?   B . n 
B 1 243 GLY 243 269 ?   ?   ?   B . n 
B 1 244 PHE 244 270 ?   ?   ?   B . n 
B 1 245 TYR 245 271 271 TYR TYR B . n 
B 1 246 GLY 246 272 272 GLY GLY B . n 
B 1 247 ARG 247 273 273 ARG ARG B . n 
B 1 248 GLU 248 274 274 GLU GLU B . n 
B 1 249 CYS 249 275 275 CYS CYS B . n 
B 1 250 ASP 250 276 276 ASP ASP B . n 
B 1 251 TRP 251 277 277 TRP TRP B . n 
B 1 252 TRP 252 278 278 TRP TRP B . n 
B 1 253 SER 253 279 279 SER SER B . n 
B 1 254 VAL 254 280 280 VAL VAL B . n 
B 1 255 GLY 255 281 281 GLY GLY B . n 
B 1 256 VAL 256 282 282 VAL VAL B . n 
B 1 257 PHE 257 283 283 PHE PHE B . n 
B 1 258 LEU 258 284 284 LEU LEU B . n 
B 1 259 TYR 259 285 285 TYR TYR B . n 
B 1 260 GLU 260 286 286 GLU GLU B . n 
B 1 261 MET 261 287 287 MET MET B . n 
B 1 262 LEU 262 288 288 LEU LEU B . n 
B 1 263 VAL 263 289 289 VAL VAL B . n 
B 1 264 GLY 264 290 290 GLY GLY B . n 
B 1 265 ASP 265 291 291 ASP ASP B . n 
B 1 266 THR 266 292 292 THR THR B . n 
B 1 267 PRO 267 293 293 PRO PRO B . n 
B 1 268 PHE 268 294 294 PHE PHE B . n 
B 1 269 TYR 269 295 295 TYR TYR B . n 
B 1 270 ALA 270 296 296 ALA ALA B . n 
B 1 271 ASP 271 297 297 ASP ASP B . n 
B 1 272 SER 272 298 298 SER SER B . n 
B 1 273 LEU 273 299 299 LEU LEU B . n 
B 1 274 VAL 274 300 300 VAL VAL B . n 
B 1 275 GLY 275 301 301 GLY GLY B . n 
B 1 276 THR 276 302 302 THR THR B . n 
B 1 277 TYR 277 303 303 TYR TYR B . n 
B 1 278 SER 278 304 304 SER SER B . n 
B 1 279 LYS 279 305 305 LYS LYS B . n 
B 1 280 ILE 280 306 306 ILE ILE B . n 
B 1 281 MET 281 307 307 MET MET B . n 
B 1 282 ASP 282 308 308 ASP ASP B . n 
B 1 283 HIS 283 309 309 HIS HIS B . n 
B 1 284 LYS 284 310 310 LYS LYS B . n 
B 1 285 ASN 285 311 311 ASN ASN B . n 
B 1 286 SER 286 312 312 SER SER B . n 
B 1 287 LEU 287 313 313 LEU LEU B . n 
B 1 288 CYS 288 314 314 CYS CYS B . n 
B 1 289 PHE 289 315 315 PHE PHE B . n 
B 1 290 PRO 290 316 316 PRO PRO B . n 
B 1 291 GLU 291 317 317 GLU GLU B . n 
B 1 292 ASP 292 318 318 ASP ASP B . n 
B 1 293 ALA 293 319 319 ALA ALA B . n 
B 1 294 GLU 294 320 320 GLU GLU B . n 
B 1 295 ILE 295 321 321 ILE ILE B . n 
B 1 296 SER 296 322 322 SER SER B . n 
B 1 297 LYS 297 323 323 LYS LYS B . n 
B 1 298 HIS 298 324 324 HIS HIS B . n 
B 1 299 ALA 299 325 325 ALA ALA B . n 
B 1 300 LYS 300 326 326 LYS LYS B . n 
B 1 301 ASN 301 327 327 ASN ASN B . n 
B 1 302 LEU 302 328 328 LEU LEU B . n 
B 1 303 ILE 303 329 329 ILE ILE B . n 
B 1 304 CYS 304 330 330 CYS CYS B . n 
B 1 305 ALA 305 331 331 ALA ALA B . n 
B 1 306 PHE 306 332 332 PHE PHE B . n 
B 1 307 LEU 307 333 333 LEU LEU B . n 
B 1 308 THR 308 334 334 THR THR B . n 
B 1 309 ASP 309 335 335 ASP ASP B . n 
B 1 310 ARG 310 336 336 ARG ARG B . n 
B 1 311 GLU 311 337 337 GLU GLU B . n 
B 1 312 VAL 312 338 338 VAL VAL B . n 
B 1 313 ARG 313 339 339 ARG ARG B . n 
B 1 314 LEU 314 340 340 LEU LEU B . n 
B 1 315 GLY 315 341 341 GLY GLY B . n 
B 1 316 ARG 316 342 342 ARG ARG B . n 
B 1 317 ASN 317 343 343 ASN ASN B . n 
B 1 318 GLY 318 344 344 GLY GLY B . n 
B 1 319 VAL 319 345 345 VAL VAL B . n 
B 1 320 GLU 320 346 346 GLU GLU B . n 
B 1 321 GLU 321 347 347 GLU GLU B . n 
B 1 322 ILE 322 348 348 ILE ILE B . n 
B 1 323 ARG 323 349 349 ARG ARG B . n 
B 1 324 GLN 324 350 350 GLN GLN B . n 
B 1 325 HIS 325 351 351 HIS HIS B . n 
B 1 326 PRO 326 352 352 PRO PRO B . n 
B 1 327 PHE 327 353 353 PHE PHE B . n 
B 1 328 PHE 328 354 354 PHE PHE B . n 
B 1 329 LYS 329 355 355 LYS LYS B . n 
B 1 330 ASN 330 356 356 ASN ASN B . n 
B 1 331 ASP 331 357 357 ASP ASP B . n 
B 1 332 GLN 332 358 358 GLN GLN B . n 
B 1 333 TRP 333 359 359 TRP TRP B . n 
B 1 334 HIS 334 360 360 HIS HIS B . n 
B 1 335 TRP 335 361 361 TRP TRP B . n 
B 1 336 ASP 336 362 362 ASP ASP B . n 
B 1 337 ASN 337 363 363 ASN ASN B . n 
B 1 338 ILE 338 364 364 ILE ILE B . n 
B 1 339 ARG 339 365 365 ARG ARG B . n 
B 1 340 GLU 340 366 366 GLU GLU B . n 
B 1 341 THR 341 367 367 THR THR B . n 
B 1 342 ALA 342 368 368 ALA ALA B . n 
B 1 343 ALA 343 369 369 ALA ALA B . n 
B 1 344 PRO 344 370 370 PRO PRO B . n 
B 1 345 VAL 345 371 371 VAL VAL B . n 
B 1 346 VAL 346 372 372 VAL VAL B . n 
B 1 347 PRO 347 373 373 PRO PRO B . n 
B 1 348 GLU 348 374 374 GLU GLU B . n 
B 1 349 LEU 349 375 375 LEU LEU B . n 
B 1 350 SER 350 376 376 SER SER B . n 
B 1 351 SER 351 377 377 SER SER B . n 
B 1 352 ASP 352 378 378 ASP ASP B . n 
B 1 353 ILE 353 379 379 ILE ILE B . n 
B 1 354 ASP 354 380 380 ASP ASP B . n 
B 1 355 SER 355 381 381 SER SER B . n 
B 1 356 SER 356 382 382 SER SER B . n 
B 1 357 ASN 357 383 383 ASN ASN B . n 
B 1 358 PHE 358 384 384 PHE PHE B . n 
B 1 359 ASP 359 385 385 ASP ASP B . n 
B 1 360 ASP 360 386 386 ASP ASP B . n 
B 1 361 ILE 361 387 387 ILE ILE B . n 
B 1 362 GLU 362 388 388 GLU GLU B . n 
B 1 363 ASP 363 389 ?   ?   ?   B . n 
B 1 364 ASP 364 390 ?   ?   ?   B . n 
B 1 365 LYS 365 391 ?   ?   ?   B . n 
B 1 366 GLY 366 392 ?   ?   ?   B . n 
B 1 367 ASP 367 393 ?   ?   ?   B . n 
B 1 368 VAL 368 394 ?   ?   ?   B . n 
B 1 369 GLU 369 395 395 GLU GLU B . n 
B 1 370 THR 370 396 396 THR THR B . n 
B 1 371 PHE 371 397 397 PHE PHE B . n 
B 1 372 PRO 372 398 398 PRO PRO B . n 
B 1 373 ILE 373 399 399 ILE ILE B . n 
B 1 374 PRO 374 400 400 PRO PRO B . n 
B 1 375 LYS 375 401 401 LYS LYS B . n 
B 1 376 ALA 376 402 402 ALA ALA B . n 
B 1 377 PHE 377 403 403 PHE PHE B . n 
B 1 378 VAL 378 404 404 VAL VAL B . n 
B 1 379 GLY 379 405 405 GLY GLY B . n 
B 1 380 ASN 380 406 406 ASN ASN B . n 
B 1 381 GLN 381 407 407 GLN GLN B . n 
B 1 382 LEU 382 408 408 LEU LEU B . n 
B 1 383 PRO 383 409 409 PRO PRO B . n 
B 1 384 PHE 384 410 410 PHE PHE B . n 
B 1 385 ILE 385 411 411 ILE ILE B . n 
B 1 386 GLY 386 412 412 GLY GLY B . n 
B 1 387 PHE 387 413 413 PHE PHE B . n 
B 1 388 THR 388 414 414 THR THR B . n 
B 1 389 TYR 389 415 415 TYR TYR B . n 
B 1 390 TYR 390 416 416 TYR TYR B . n 
B 1 391 ARG 391 417 417 ARG ARG B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 YEW ? ? YEW ? ? 'SUBJECT OF INVESTIGATION' ? 
2 SO4 ? ? SO4 ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 YEW 1  501 501 YEW DRG A . 
D 3 SO4 1  502 1   SO4 SO4 A . 
E 2 YEW 1  501 501 YEW DRG B . 
F 4 HOH 1  601 47  HOH HOH A . 
F 4 HOH 2  602 49  HOH HOH A . 
F 4 HOH 3  603 48  HOH HOH A . 
F 4 HOH 4  604 35  HOH HOH A . 
F 4 HOH 5  605 4   HOH HOH A . 
F 4 HOH 6  606 31  HOH HOH A . 
F 4 HOH 7  607 43  HOH HOH A . 
F 4 HOH 8  608 50  HOH HOH A . 
F 4 HOH 9  609 2   HOH HOH A . 
F 4 HOH 10 610 21  HOH HOH A . 
F 4 HOH 11 611 25  HOH HOH A . 
F 4 HOH 12 612 30  HOH HOH A . 
F 4 HOH 13 613 5   HOH HOH A . 
F 4 HOH 14 614 11  HOH HOH A . 
F 4 HOH 15 615 7   HOH HOH A . 
F 4 HOH 16 616 39  HOH HOH A . 
F 4 HOH 17 617 17  HOH HOH A . 
F 4 HOH 18 618 81  HOH HOH A . 
F 4 HOH 19 619 37  HOH HOH A . 
F 4 HOH 20 620 18  HOH HOH A . 
F 4 HOH 21 621 1   HOH HOH A . 
F 4 HOH 22 622 20  HOH HOH A . 
F 4 HOH 23 623 13  HOH HOH A . 
F 4 HOH 24 624 79  HOH HOH A . 
F 4 HOH 25 625 42  HOH HOH A . 
F 4 HOH 26 626 14  HOH HOH A . 
F 4 HOH 27 627 51  HOH HOH A . 
F 4 HOH 28 628 45  HOH HOH A . 
F 4 HOH 29 629 3   HOH HOH A . 
F 4 HOH 30 630 6   HOH HOH A . 
F 4 HOH 31 631 29  HOH HOH A . 
F 4 HOH 32 632 12  HOH HOH A . 
F 4 HOH 33 633 40  HOH HOH A . 
F 4 HOH 34 634 27  HOH HOH A . 
F 4 HOH 35 635 78  HOH HOH A . 
F 4 HOH 36 636 41  HOH HOH A . 
F 4 HOH 37 637 24  HOH HOH A . 
F 4 HOH 38 638 28  HOH HOH A . 
F 4 HOH 39 639 52  HOH HOH A . 
F 4 HOH 40 640 19  HOH HOH A . 
F 4 HOH 41 641 36  HOH HOH A . 
F 4 HOH 42 642 46  HOH HOH A . 
F 4 HOH 43 643 33  HOH HOH A . 
F 4 HOH 44 644 15  HOH HOH A . 
F 4 HOH 45 645 26  HOH HOH A . 
F 4 HOH 46 646 32  HOH HOH A . 
F 4 HOH 47 647 34  HOH HOH A . 
F 4 HOH 48 648 80  HOH HOH A . 
F 4 HOH 49 649 16  HOH HOH A . 
F 4 HOH 50 650 77  HOH HOH A . 
F 4 HOH 51 651 82  HOH HOH A . 
F 4 HOH 52 652 22  HOH HOH A . 
F 4 HOH 53 653 38  HOH HOH A . 
F 4 HOH 54 654 44  HOH HOH A . 
G 4 HOH 1  601 62  HOH HOH B . 
G 4 HOH 2  602 73  HOH HOH B . 
G 4 HOH 3  603 70  HOH HOH B . 
G 4 HOH 4  604 76  HOH HOH B . 
G 4 HOH 5  605 63  HOH HOH B . 
G 4 HOH 6  606 66  HOH HOH B . 
G 4 HOH 7  607 58  HOH HOH B . 
G 4 HOH 8  608 59  HOH HOH B . 
G 4 HOH 9  609 55  HOH HOH B . 
G 4 HOH 10 610 54  HOH HOH B . 
G 4 HOH 11 611 53  HOH HOH B . 
G 4 HOH 12 612 64  HOH HOH B . 
G 4 HOH 13 613 69  HOH HOH B . 
G 4 HOH 14 614 68  HOH HOH B . 
G 4 HOH 15 615 57  HOH HOH B . 
G 4 HOH 16 616 60  HOH HOH B . 
G 4 HOH 17 617 74  HOH HOH B . 
G 4 HOH 18 618 71  HOH HOH B . 
G 4 HOH 19 619 75  HOH HOH B . 
G 4 HOH 20 620 67  HOH HOH B . 
G 4 HOH 21 621 83  HOH HOH B . 
G 4 HOH 22 622 56  HOH HOH B . 
G 4 HOH 23 623 72  HOH HOH B . 
G 4 HOH 24 624 84  HOH HOH B . 
G 4 HOH 25 625 85  HOH HOH B . 
G 4 HOH 26 626 23  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A LYS 29  ? CG  ? A LYS 3   CG  
2   1 Y 1 A LYS 29  ? CD  ? A LYS 3   CD  
3   1 Y 1 A LYS 29  ? CE  ? A LYS 3   CE  
4   1 Y 1 A LYS 29  ? NZ  ? A LYS 3   NZ  
5   1 Y 1 A GLU 31  ? CG  ? A GLU 5   CG  
6   1 Y 1 A GLU 31  ? CD  ? A GLU 5   CD  
7   1 Y 1 A GLU 31  ? OE1 ? A GLU 5   OE1 
8   1 Y 1 A GLU 31  ? OE2 ? A GLU 5   OE2 
9   1 Y 1 A ARG 35  ? CG  ? A ARG 9   CG  
10  1 Y 1 A ARG 35  ? CD  ? A ARG 9   CD  
11  1 Y 1 A ARG 35  ? NE  ? A ARG 9   NE  
12  1 Y 1 A ARG 35  ? CZ  ? A ARG 9   CZ  
13  1 Y 1 A ARG 35  ? NH1 ? A ARG 9   NH1 
14  1 Y 1 A ARG 35  ? NH2 ? A ARG 9   NH2 
15  1 Y 1 A ARG 38  ? CG  ? A ARG 12  CG  
16  1 Y 1 A ARG 38  ? CD  ? A ARG 12  CD  
17  1 Y 1 A ARG 38  ? NE  ? A ARG 12  NE  
18  1 Y 1 A ARG 38  ? CZ  ? A ARG 12  CZ  
19  1 Y 1 A ARG 38  ? NH1 ? A ARG 12  NH1 
20  1 Y 1 A ARG 38  ? NH2 ? A ARG 12  NH2 
21  1 Y 1 A LYS 64  ? CG  ? A LYS 38  CG  
22  1 Y 1 A LYS 64  ? CD  ? A LYS 38  CD  
23  1 Y 1 A LYS 64  ? CE  ? A LYS 38  CE  
24  1 Y 1 A LYS 64  ? NZ  ? A LYS 38  NZ  
25  1 Y 1 A LYS 66  ? CG  ? A LYS 40  CG  
26  1 Y 1 A LYS 66  ? CD  ? A LYS 40  CD  
27  1 Y 1 A LYS 66  ? CE  ? A LYS 40  CE  
28  1 Y 1 A LYS 66  ? NZ  ? A LYS 40  NZ  
29  1 Y 1 A ASN 70  ? CG  ? A ASN 44  CG  
30  1 Y 1 A ASN 70  ? OD1 ? A ASN 44  OD1 
31  1 Y 1 A ASN 70  ? ND2 ? A ASN 44  ND2 
32  1 Y 1 A GLU 76  ? CG  ? A GLU 50  CG  
33  1 Y 1 A GLU 76  ? CD  ? A GLU 50  CD  
34  1 Y 1 A GLU 76  ? OE1 ? A GLU 50  OE1 
35  1 Y 1 A GLU 76  ? OE2 ? A GLU 50  OE2 
36  1 Y 1 A LYS 77  ? CG  ? A LYS 51  CG  
37  1 Y 1 A LYS 77  ? CD  ? A LYS 51  CD  
38  1 Y 1 A LYS 77  ? CE  ? A LYS 51  CE  
39  1 Y 1 A LYS 77  ? NZ  ? A LYS 51  NZ  
40  1 Y 1 A LYS 80  ? CG  ? A LYS 54  CG  
41  1 Y 1 A LYS 80  ? CD  ? A LYS 54  CD  
42  1 Y 1 A LYS 80  ? CE  ? A LYS 54  CE  
43  1 Y 1 A LYS 80  ? NZ  ? A LYS 54  NZ  
44  1 Y 1 A LYS 81  ? CG  ? A LYS 55  CG  
45  1 Y 1 A LYS 81  ? CD  ? A LYS 55  CD  
46  1 Y 1 A LYS 81  ? CE  ? A LYS 55  CE  
47  1 Y 1 A LYS 81  ? NZ  ? A LYS 55  NZ  
48  1 Y 1 A ARG 100 ? CG  ? A ARG 74  CG  
49  1 Y 1 A ARG 100 ? CD  ? A ARG 74  CD  
50  1 Y 1 A ARG 100 ? NE  ? A ARG 74  NE  
51  1 Y 1 A ARG 100 ? CZ  ? A ARG 74  CZ  
52  1 Y 1 A ARG 100 ? NH1 ? A ARG 74  NH1 
53  1 Y 1 A ARG 100 ? NH2 ? A ARG 74  NH2 
54  1 Y 1 A LYS 130 ? CG  ? A LYS 104 CG  
55  1 Y 1 A LYS 130 ? CD  ? A LYS 104 CD  
56  1 Y 1 A LYS 130 ? CE  ? A LYS 104 CE  
57  1 Y 1 A LYS 130 ? NZ  ? A LYS 104 NZ  
58  1 Y 1 A LYS 189 ? CG  ? A LYS 163 CG  
59  1 Y 1 A LYS 189 ? CD  ? A LYS 163 CD  
60  1 Y 1 A LYS 189 ? CE  ? A LYS 163 CE  
61  1 Y 1 A LYS 189 ? NZ  ? A LYS 163 NZ  
62  1 Y 1 A LYS 310 ? CG  ? A LYS 284 CG  
63  1 Y 1 A LYS 310 ? CD  ? A LYS 284 CD  
64  1 Y 1 A LYS 310 ? CE  ? A LYS 284 CE  
65  1 Y 1 A LYS 310 ? NZ  ? A LYS 284 NZ  
66  1 Y 1 A GLU 374 ? CG  ? A GLU 348 CG  
67  1 Y 1 A GLU 374 ? CD  ? A GLU 348 CD  
68  1 Y 1 A GLU 374 ? OE1 ? A GLU 348 OE1 
69  1 Y 1 A GLU 374 ? OE2 ? A GLU 348 OE2 
70  1 Y 1 A GLU 388 ? CG  ? A GLU 362 CG  
71  1 Y 1 A GLU 388 ? CD  ? A GLU 362 CD  
72  1 Y 1 A GLU 388 ? OE1 ? A GLU 362 OE1 
73  1 Y 1 A GLU 388 ? OE2 ? A GLU 362 OE2 
74  1 Y 1 A ASP 389 ? CG  ? A ASP 363 CG  
75  1 Y 1 A ASP 389 ? OD1 ? A ASP 363 OD1 
76  1 Y 1 A ASP 389 ? OD2 ? A ASP 363 OD2 
77  1 Y 1 A LYS 401 ? CG  ? A LYS 375 CG  
78  1 Y 1 A LYS 401 ? CD  ? A LYS 375 CD  
79  1 Y 1 A LYS 401 ? CE  ? A LYS 375 CE  
80  1 Y 1 A LYS 401 ? NZ  ? A LYS 375 NZ  
81  1 Y 1 B LYS 29  ? CG  ? B LYS 3   CG  
82  1 Y 1 B LYS 29  ? CD  ? B LYS 3   CD  
83  1 Y 1 B LYS 29  ? CE  ? B LYS 3   CE  
84  1 Y 1 B LYS 29  ? NZ  ? B LYS 3   NZ  
85  1 Y 1 B GLU 31  ? CG  ? B GLU 5   CG  
86  1 Y 1 B GLU 31  ? CD  ? B GLU 5   CD  
87  1 Y 1 B GLU 31  ? OE1 ? B GLU 5   OE1 
88  1 Y 1 B GLU 31  ? OE2 ? B GLU 5   OE2 
89  1 Y 1 B ARG 35  ? CG  ? B ARG 9   CG  
90  1 Y 1 B ARG 35  ? CD  ? B ARG 9   CD  
91  1 Y 1 B ARG 35  ? NE  ? B ARG 9   NE  
92  1 Y 1 B ARG 35  ? CZ  ? B ARG 9   CZ  
93  1 Y 1 B ARG 35  ? NH1 ? B ARG 9   NH1 
94  1 Y 1 B ARG 35  ? NH2 ? B ARG 9   NH2 
95  1 Y 1 B LYS 66  ? CG  ? B LYS 40  CG  
96  1 Y 1 B LYS 66  ? CD  ? B LYS 40  CD  
97  1 Y 1 B LYS 66  ? CE  ? B LYS 40  CE  
98  1 Y 1 B LYS 66  ? NZ  ? B LYS 40  NZ  
99  1 Y 1 B LYS 77  ? CG  ? B LYS 51  CG  
100 1 Y 1 B LYS 77  ? CD  ? B LYS 51  CD  
101 1 Y 1 B LYS 77  ? CE  ? B LYS 51  CE  
102 1 Y 1 B LYS 77  ? NZ  ? B LYS 51  NZ  
103 1 Y 1 B LYS 80  ? CG  ? B LYS 54  CG  
104 1 Y 1 B LYS 80  ? CD  ? B LYS 54  CD  
105 1 Y 1 B LYS 80  ? CE  ? B LYS 54  CE  
106 1 Y 1 B LYS 80  ? NZ  ? B LYS 54  NZ  
107 1 Y 1 B ARG 100 ? CG  ? B ARG 74  CG  
108 1 Y 1 B ARG 100 ? CD  ? B ARG 74  CD  
109 1 Y 1 B ARG 100 ? NE  ? B ARG 74  NE  
110 1 Y 1 B ARG 100 ? CZ  ? B ARG 74  CZ  
111 1 Y 1 B ARG 100 ? NH1 ? B ARG 74  NH1 
112 1 Y 1 B ARG 100 ? NH2 ? B ARG 74  NH2 
113 1 Y 1 B LYS 130 ? CG  ? B LYS 104 CG  
114 1 Y 1 B LYS 130 ? CD  ? B LYS 104 CD  
115 1 Y 1 B LYS 130 ? CE  ? B LYS 104 CE  
116 1 Y 1 B LYS 130 ? NZ  ? B LYS 104 NZ  
117 1 Y 1 B LYS 189 ? CG  ? B LYS 163 CG  
118 1 Y 1 B LYS 189 ? CD  ? B LYS 163 CD  
119 1 Y 1 B LYS 189 ? CE  ? B LYS 163 CE  
120 1 Y 1 B LYS 189 ? NZ  ? B LYS 163 NZ  
121 1 Y 1 B LYS 224 ? CG  ? B LYS 198 CG  
122 1 Y 1 B LYS 224 ? CD  ? B LYS 198 CD  
123 1 Y 1 B LYS 224 ? CE  ? B LYS 198 CE  
124 1 Y 1 B LYS 224 ? NZ  ? B LYS 198 NZ  
125 1 Y 1 B LYS 238 ? CG  ? B LYS 212 CG  
126 1 Y 1 B LYS 238 ? CD  ? B LYS 212 CD  
127 1 Y 1 B LYS 238 ? CE  ? B LYS 212 CE  
128 1 Y 1 B LYS 238 ? NZ  ? B LYS 212 NZ  
129 1 Y 1 B MET 239 ? CG  ? B MET 213 CG  
130 1 Y 1 B MET 239 ? SD  ? B MET 213 SD  
131 1 Y 1 B MET 239 ? CE  ? B MET 213 CE  
132 1 Y 1 B LYS 310 ? CG  ? B LYS 284 CG  
133 1 Y 1 B LYS 310 ? CD  ? B LYS 284 CD  
134 1 Y 1 B LYS 310 ? CE  ? B LYS 284 CE  
135 1 Y 1 B LYS 310 ? NZ  ? B LYS 284 NZ  
136 1 Y 1 B GLU 317 ? CG  ? B GLU 291 CG  
137 1 Y 1 B GLU 317 ? CD  ? B GLU 291 CD  
138 1 Y 1 B GLU 317 ? OE1 ? B GLU 291 OE1 
139 1 Y 1 B GLU 317 ? OE2 ? B GLU 291 OE2 
140 1 Y 1 B ASP 318 ? CG  ? B ASP 292 CG  
141 1 Y 1 B ASP 318 ? OD1 ? B ASP 292 OD1 
142 1 Y 1 B ASP 318 ? OD2 ? B ASP 292 OD2 
143 1 Y 1 B GLU 320 ? CG  ? B GLU 294 CG  
144 1 Y 1 B GLU 320 ? CD  ? B GLU 294 CD  
145 1 Y 1 B GLU 320 ? OE1 ? B GLU 294 OE1 
146 1 Y 1 B GLU 320 ? OE2 ? B GLU 294 OE2 
147 1 Y 1 B LYS 326 ? CG  ? B LYS 300 CG  
148 1 Y 1 B LYS 326 ? CD  ? B LYS 300 CD  
149 1 Y 1 B LYS 326 ? CE  ? B LYS 300 CE  
150 1 Y 1 B LYS 326 ? NZ  ? B LYS 300 NZ  
151 1 Y 1 B GLU 337 ? CG  ? B GLU 311 CG  
152 1 Y 1 B GLU 337 ? CD  ? B GLU 311 CD  
153 1 Y 1 B GLU 337 ? OE1 ? B GLU 311 OE1 
154 1 Y 1 B GLU 337 ? OE2 ? B GLU 311 OE2 
155 1 Y 1 B GLU 346 ? CG  ? B GLU 320 CG  
156 1 Y 1 B GLU 346 ? CD  ? B GLU 320 CD  
157 1 Y 1 B GLU 346 ? OE1 ? B GLU 320 OE1 
158 1 Y 1 B GLU 346 ? OE2 ? B GLU 320 OE2 
159 1 Y 1 B GLN 350 ? CG  ? B GLN 324 CG  
160 1 Y 1 B GLN 350 ? CD  ? B GLN 324 CD  
161 1 Y 1 B GLN 350 ? OE1 ? B GLN 324 OE1 
162 1 Y 1 B GLN 350 ? NE2 ? B GLN 324 NE2 
163 1 Y 1 B LYS 355 ? CG  ? B LYS 329 CG  
164 1 Y 1 B LYS 355 ? CD  ? B LYS 329 CD  
165 1 Y 1 B LYS 355 ? CE  ? B LYS 329 CE  
166 1 Y 1 B LYS 355 ? NZ  ? B LYS 329 NZ  
167 1 Y 1 B GLU 374 ? CG  ? B GLU 348 CG  
168 1 Y 1 B GLU 374 ? CD  ? B GLU 348 CD  
169 1 Y 1 B GLU 374 ? OE1 ? B GLU 348 OE1 
170 1 Y 1 B GLU 374 ? OE2 ? B GLU 348 OE2 
171 1 Y 1 B GLU 388 ? CG  ? B GLU 362 CG  
172 1 Y 1 B GLU 388 ? CD  ? B GLU 362 CD  
173 1 Y 1 B GLU 388 ? OE1 ? B GLU 362 OE1 
174 1 Y 1 B GLU 388 ? OE2 ? B GLU 362 OE2 
175 1 Y 1 B GLU 395 ? CG  ? B GLU 369 CG  
176 1 Y 1 B GLU 395 ? CD  ? B GLU 369 CD  
177 1 Y 1 B GLU 395 ? OE1 ? B GLU 369 OE1 
178 1 Y 1 B GLU 395 ? OE2 ? B GLU 369 OE2 
179 1 Y 1 B LYS 401 ? CG  ? B LYS 375 CG  
180 1 Y 1 B LYS 401 ? CD  ? B LYS 375 CD  
181 1 Y 1 B LYS 401 ? CE  ? B LYS 375 CE  
182 1 Y 1 B LYS 401 ? NZ  ? B LYS 375 NZ  
183 1 Y 1 B ARG 417 ? CG  ? B ARG 391 CG  
184 1 Y 1 B ARG 417 ? CD  ? B ARG 391 CD  
185 1 Y 1 B ARG 417 ? NE  ? B ARG 391 NE  
186 1 Y 1 B ARG 417 ? CZ  ? B ARG 391 CZ  
187 1 Y 1 B ARG 417 ? NH1 ? B ARG 391 NH1 
188 1 Y 1 B ARG 417 ? NH2 ? B ARG 391 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? v1.21 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .     2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .     3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP ? ? ? .     4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8X92 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     53.727 
_cell.length_a_esd                 ? 
_cell.length_b                     136.467 
_cell.length_b_esd                 ? 
_cell.length_c                     148.574 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8X92 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8X92 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.02 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          59.33 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '2.5 M Ammonium sulfate, 0.1 M Bis-tris (pH5.5)' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            287 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-11-11 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL44XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL44XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8X92 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.2 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     106703 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.52 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.39 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.064 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.055 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
2.20 2.33 ? ? ? ? ? ? 16959 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1.473 ? ? 1 1 0.425 ? ? ? ? 1.238 ? ? ? ? ? ? ? ? ? 
2.33 2.49 ? ? ? ? ? ? 16221 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.877 ? ? 2 1 0.704 ? ? ? ? 0.74  ? ? ? ? ? ? ? ? ? 
2.49 2.69 ? ? ? ? ? ? 15226 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.5   ? ? 3 1 0.883 ? ? ? ? 0.427 ? ? ? ? ? ? ? ? ? 
2.69 2.95 ? ? ? ? ? ? 13911 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.252 ? ? 4 1 0.965 ? ? ? ? 0.215 ? ? ? ? ? ? ? ? ? 
2.95 3.29 ? ? ? ? ? ? 12580 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.121 ? ? 5 1 0.989 ? ? ? ? 0.102 ? ? ? ? ? ? ? ? ? 
3.29 3.8  ? ? ? ? ? ? 11141 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.067 ? ? 6 1 0.995 ? ? ? ? 0.056 ? ? ? ? ? ? ? ? ? 
3.80 4.65 ? ? ? ? ? ? 9355  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.049 ? ? 7 1 0.997 ? ? ? ? 0.042 ? ? ? ? ? ? ? ? ? 
4.65 6.54 ? ? ? ? ? ? 7261  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.044 ? ? 8 1 0.997 ? ? ? ? 0.037 ? ? ? ? ? ? ? ? ? 
6.54 50   ? ? ? ? ? ? 4049  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.037 ? ? 9 1 0.998 ? ? ? ? 0.031 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               71.3 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8X92 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.2 
_refine.ls_d_res_low                             47.382 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     106662 
_refine.ls_number_reflns_R_free                  3810 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.42 
_refine.ls_percent_reflns_R_free                 3.57 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2397 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2089 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      4L6Q 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.2 
_refine_hist.d_res_low                        47.382 
_refine_hist.number_atoms_solvent             80 
_refine_hist.number_atoms_total               6056 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        5971 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         5 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.2 
_refine_ls_shell.d_res_low                        2.278 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             ? 
_refine_ls_shell.number_reflns_R_work             5361 
_refine_ls_shell.percent_reflns_obs               96.91 
_refine_ls_shell.percent_reflns_R_free            3.57 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.3507 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.3695 
# 
_struct.entry_id                     8X92 
_struct.title                        'Crystal structure of ROCK2 with GNS-2666 inhibitor' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8X92 
_struct_keywords.text            'Inhibitor, TRANSFERASE, TRANSFERASE-INHIBITOR complex' 
_struct_keywords.pdbx_keywords   TRANSFERASE/INHIBITOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 4 ? 
G N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    ROCK2_HUMAN 
_struct_ref.pdbx_db_accession          O75116 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEV
QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV
PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG
GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVE
EIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYR
;
_struct_ref.pdbx_align_begin           27 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8X92 A 1 ? 391 ? O75116 27 ? 417 ? 27 417 
2 1 8X92 B 1 ? 391 ? O75116 27 ? 417 ? 27 417 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,F 
2 1 B,E,G   
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LEU A 4   ? ASP A 10  ? LEU A 30  ASP A 36  1 ? 7  
HELX_P HELX_P2  AA2 ASN A 16  ? ASP A 32  ? ASN A 42  ASP A 58  1 ? 17 
HELX_P HELX_P3  AA3 ALA A 35  ? LYS A 38  ? ALA A 61  LYS A 64  5 ? 4  
HELX_P HELX_P4  AA4 ASN A 39  ? GLN A 60  ? ASN A 65  GLN A 86  1 ? 22 
HELX_P HELX_P5  AA5 LYS A 62  ? GLU A 64  ? LYS A 88  GLU A 90  5 ? 3  
HELX_P HELX_P6  AA6 LYS A 99  ? ARG A 105 ? LYS A 125 ARG A 131 1 ? 7  
HELX_P HELX_P7  AA7 PHE A 110 ? ALA A 121 ? PHE A 136 ALA A 147 1 ? 12 
HELX_P HELX_P8  AA8 ASP A 150 ? TYR A 158 ? ASP A 176 TYR A 184 1 ? 9  
HELX_P HELX_P9  AA9 PRO A 161 ? MET A 182 ? PRO A 187 MET A 208 1 ? 22 
HELX_P HELX_P10 AB1 LYS A 190 ? ASP A 192 ? LYS A 216 ASP A 218 5 ? 3  
HELX_P HELX_P11 AB2 THR A 227 ? ILE A 231 ? THR A 253 ILE A 257 5 ? 5  
HELX_P HELX_P12 AB3 SER A 232 ? SER A 238 ? SER A 258 SER A 264 1 ? 7  
HELX_P HELX_P13 AB4 ARG A 247 ? GLY A 264 ? ARG A 273 GLY A 290 1 ? 18 
HELX_P HELX_P14 AB5 SER A 272 ? ASP A 282 ? SER A 298 ASP A 308 1 ? 11 
HELX_P HELX_P15 AB6 ASP A 282 ? LEU A 287 ? ASP A 308 LEU A 313 1 ? 6  
HELX_P HELX_P16 AB7 SER A 296 ? LEU A 307 ? SER A 322 LEU A 333 1 ? 12 
HELX_P HELX_P17 AB8 ASP A 309 ? ARG A 313 ? ASP A 335 ARG A 339 5 ? 5  
HELX_P HELX_P18 AB9 VAL A 319 ? GLN A 324 ? VAL A 345 GLN A 350 1 ? 6  
HELX_P HELX_P19 AC1 HIS A 325 ? LYS A 329 ? HIS A 351 LYS A 355 5 ? 5  
HELX_P HELX_P20 AC2 ASN A 337 ? THR A 341 ? ASN A 363 THR A 367 5 ? 5  
HELX_P HELX_P21 AC3 GLN A 381 ? ILE A 385 ? GLN A 407 ILE A 411 5 ? 5  
HELX_P HELX_P22 AC4 LEU B 4   ? ASP B 10  ? LEU B 30  ASP B 36  1 ? 7  
HELX_P HELX_P23 AC5 ASN B 16  ? ASP B 30  ? ASN B 42  ASP B 56  1 ? 15 
HELX_P HELX_P24 AC6 ALA B 35  ? LYS B 38  ? ALA B 61  LYS B 64  5 ? 4  
HELX_P HELX_P25 AC7 ASN B 39  ? GLN B 60  ? ASN B 65  GLN B 86  1 ? 22 
HELX_P HELX_P26 AC8 LYS B 62  ? GLU B 64  ? LYS B 88  GLU B 90  5 ? 3  
HELX_P HELX_P27 AC9 LYS B 99  ? LYS B 104 ? LYS B 125 LYS B 130 1 ? 6  
HELX_P HELX_P28 AD1 PHE B 111 ? ALA B 121 ? PHE B 137 ALA B 147 1 ? 11 
HELX_P HELX_P29 AD2 ASP B 150 ? TYR B 158 ? ASP B 176 TYR B 184 1 ? 9  
HELX_P HELX_P30 AD3 PRO B 161 ? MET B 182 ? PRO B 187 MET B 208 1 ? 22 
HELX_P HELX_P31 AD4 LYS B 190 ? ASP B 192 ? LYS B 216 ASP B 218 5 ? 3  
HELX_P HELX_P32 AD5 SER B 232 ? GLN B 239 ? SER B 258 GLN B 265 1 ? 8  
HELX_P HELX_P33 AD6 GLU B 248 ? GLY B 264 ? GLU B 274 GLY B 290 1 ? 17 
HELX_P HELX_P34 AD7 SER B 272 ? ASP B 282 ? SER B 298 ASP B 308 1 ? 11 
HELX_P HELX_P35 AD8 ASP B 282 ? LEU B 287 ? ASP B 308 LEU B 313 1 ? 6  
HELX_P HELX_P36 AD9 SER B 296 ? LEU B 307 ? SER B 322 LEU B 333 1 ? 12 
HELX_P HELX_P37 AE1 ASP B 309 ? ARG B 313 ? ASP B 335 ARG B 339 5 ? 5  
HELX_P HELX_P38 AE2 VAL B 319 ? GLN B 324 ? VAL B 345 GLN B 350 1 ? 6  
HELX_P HELX_P39 AE3 HIS B 325 ? LYS B 329 ? HIS B 351 LYS B 355 5 ? 5  
HELX_P HELX_P40 AE4 ASN B 337 ? THR B 341 ? ASN B 363 THR B 367 5 ? 5  
HELX_P HELX_P41 AE5 GLN B 381 ? ILE B 385 ? GLN B 407 ILE B 411 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 6 ? 
AA6 ? 2 ? 
AA7 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 66  ? GLY A 75  ? TYR A 92  GLY A 101 
AA1 2 GLY A 78  ? HIS A 85  ? GLY A 104 HIS A 111 
AA1 3 VAL A 91  ? SER A 98  ? VAL A 117 SER A 124 
AA1 4 TYR A 138 ? MET A 143 ? TYR A 164 MET A 169 
AA1 5 LEU A 129 ? GLN A 134 ? LEU A 155 GLN A 160 
AA2 1 LEU A 184 ? ILE A 185 ? LEU A 210 ILE A 211 
AA2 2 MET A 211 ? LYS A 212 ? MET A 237 LYS A 238 
AA3 1 MET A 194 ? LEU A 196 ? MET A 220 LEU A 222 
AA3 2 LEU A 202 ? LEU A 204 ? LEU A 228 LEU A 230 
AA4 1 MET A 218 ? CYS A 221 ? MET A 244 CYS A 247 
AA4 2 GLY A 243 ? GLY A 246 ? GLY A 269 GLY A 272 
AA5 1 TYR B 66  ? ARG B 74  ? TYR B 92  ARG B 100 
AA5 2 GLY B 78  ? HIS B 85  ? GLY B 104 HIS B 111 
AA5 3 VAL B 91  ? SER B 98  ? VAL B 117 SER B 124 
AA5 4 TYR B 138 ? MET B 143 ? TYR B 164 MET B 169 
AA5 5 LEU B 129 ? GLN B 134 ? LEU B 155 GLN B 160 
AA5 6 TYR B 389 ? TYR B 390 ? TYR B 415 TYR B 416 
AA6 1 LEU B 184 ? ILE B 185 ? LEU B 210 ILE B 211 
AA6 2 MET B 211 ? LYS B 212 ? MET B 237 LYS B 238 
AA7 1 MET B 194 ? LEU B 196 ? MET B 220 LEU B 222 
AA7 2 LEU B 202 ? LEU B 204 ? LEU B 228 LEU B 230 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LYS A 70  ? N LYS A 96  O LEU A 82  ? O LEU A 108 
AA1 2 3 N GLN A 81  ? N GLN A 107 O MET A 94  ? O MET A 120 
AA1 3 4 N ALA A 93  ? N ALA A 119 O MET A 143 ? O MET A 169 
AA1 4 5 O VAL A 142 ? O VAL A 168 N TYR A 131 ? N TYR A 157 
AA2 1 2 N ILE A 185 ? N ILE A 211 O MET A 211 ? O MET A 237 
AA3 1 2 N LEU A 195 ? N LEU A 221 O LYS A 203 ? O LYS A 229 
AA4 1 2 N VAL A 219 ? N VAL A 245 O TYR A 245 ? O TYR A 271 
AA5 1 2 N VAL B 69  ? N VAL B 95  O LEU B 82  ? O LEU B 108 
AA5 2 3 N GLN B 81  ? N GLN B 107 O MET B 94  ? O MET B 120 
AA5 3 4 N ALA B 93  ? N ALA B 119 O MET B 143 ? O MET B 169 
AA5 4 5 O VAL B 142 ? O VAL B 168 N TYR B 131 ? N TYR B 157 
AA5 5 6 N ALA B 132 ? N ALA B 158 O TYR B 389 ? O TYR B 415 
AA6 1 2 N ILE B 185 ? N ILE B 211 O MET B 211 ? O MET B 237 
AA7 1 2 N LEU B 195 ? N LEU B 221 O LYS B 203 ? O LYS B 229 
# 
_pdbx_entry_details.entry_id                   8X92 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 74  ? ? CZ A ARG 74  ? ? NH1 A ARG 74  ? ? 115.71 120.30 -4.59  0.50 N 
2 1 NE A ARG 74  ? ? CZ A ARG 74  ? ? NH2 A ARG 74  ? ? 123.95 120.30 3.65   0.50 N 
3 1 CA B LEU 177 ? ? CB B LEU 177 ? ? CG  B LEU 177 ? ? 99.36  115.30 -15.94 2.30 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS A 96  ? ? -172.22 148.16 
2  1 ARG A 213 ? ? 76.65   -10.00 
3  1 ALA A 231 ? ? -130.17 -37.88 
4  1 ASP A 240 ? ? -59.38  175.43 
5  1 ASP A 308 ? ? -97.77  36.56  
6  1 LYS B 96  ? ? -170.72 143.20 
7  1 ARG B 213 ? ? 78.59   -25.26 
8  1 ALA B 231 ? ? -130.25 -35.39 
9  1 VAL B 251 ? ? -131.54 -42.51 
10 1 ASP B 308 ? ? -96.12  36.63  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLN 27  ? A GLN 1   
2  1 Y 1 A ARG 28  ? A ARG 2   
3  1 Y 1 A ASP 390 ? A ASP 364 
4  1 Y 1 A LYS 391 ? A LYS 365 
5  1 Y 1 A GLY 392 ? A GLY 366 
6  1 Y 1 A ASP 393 ? A ASP 367 
7  1 Y 1 A ARG 417 ? A ARG 391 
8  1 Y 1 B GLN 27  ? B GLN 1   
9  1 Y 1 B ARG 28  ? B ARG 2   
10 1 Y 1 B ASP 240 ? B ASP 214 
11 1 Y 1 B GLU 241 ? B GLU 215 
12 1 Y 1 B THR 242 ? B THR 216 
13 1 Y 1 B GLY 243 ? B GLY 217 
14 1 Y 1 B MET 244 ? B MET 218 
15 1 Y 1 B VAL 245 ? B VAL 219 
16 1 Y 1 B HIS 246 ? B HIS 220 
17 1 Y 1 B CYS 247 ? B CYS 221 
18 1 Y 1 B ASP 248 ? B ASP 222 
19 1 Y 1 B THR 249 ? B THR 223 
20 1 Y 1 B GLY 266 ? B GLY 240 
21 1 Y 1 B GLY 267 ? B GLY 241 
22 1 Y 1 B ASP 268 ? B ASP 242 
23 1 Y 1 B GLY 269 ? B GLY 243 
24 1 Y 1 B PHE 270 ? B PHE 244 
25 1 Y 1 B ASP 389 ? B ASP 363 
26 1 Y 1 B ASP 390 ? B ASP 364 
27 1 Y 1 B LYS 391 ? B LYS 365 
28 1 Y 1 B GLY 392 ? B GLY 366 
29 1 Y 1 B ASP 393 ? B ASP 367 
30 1 Y 1 B VAL 394 ? B VAL 368 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
SO4 S    S N N 304 
SO4 O1   O N N 305 
SO4 O2   O N N 306 
SO4 O3   O N N 307 
SO4 O4   O N N 308 
THR N    N N N 309 
THR CA   C N S 310 
THR C    C N N 311 
THR O    O N N 312 
THR CB   C N R 313 
THR OG1  O N N 314 
THR CG2  C N N 315 
THR OXT  O N N 316 
THR H    H N N 317 
THR H2   H N N 318 
THR HA   H N N 319 
THR HB   H N N 320 
THR HG1  H N N 321 
THR HG21 H N N 322 
THR HG22 H N N 323 
THR HG23 H N N 324 
THR HXT  H N N 325 
TRP N    N N N 326 
TRP CA   C N S 327 
TRP C    C N N 328 
TRP O    O N N 329 
TRP CB   C N N 330 
TRP CG   C Y N 331 
TRP CD1  C Y N 332 
TRP CD2  C Y N 333 
TRP NE1  N Y N 334 
TRP CE2  C Y N 335 
TRP CE3  C Y N 336 
TRP CZ2  C Y N 337 
TRP CZ3  C Y N 338 
TRP CH2  C Y N 339 
TRP OXT  O N N 340 
TRP H    H N N 341 
TRP H2   H N N 342 
TRP HA   H N N 343 
TRP HB2  H N N 344 
TRP HB3  H N N 345 
TRP HD1  H N N 346 
TRP HE1  H N N 347 
TRP HE3  H N N 348 
TRP HZ2  H N N 349 
TRP HZ3  H N N 350 
TRP HH2  H N N 351 
TRP HXT  H N N 352 
TYR N    N N N 353 
TYR CA   C N S 354 
TYR C    C N N 355 
TYR O    O N N 356 
TYR CB   C N N 357 
TYR CG   C Y N 358 
TYR CD1  C Y N 359 
TYR CD2  C Y N 360 
TYR CE1  C Y N 361 
TYR CE2  C Y N 362 
TYR CZ   C Y N 363 
TYR OH   O N N 364 
TYR OXT  O N N 365 
TYR H    H N N 366 
TYR H2   H N N 367 
TYR HA   H N N 368 
TYR HB2  H N N 369 
TYR HB3  H N N 370 
TYR HD1  H N N 371 
TYR HD2  H N N 372 
TYR HE1  H N N 373 
TYR HE2  H N N 374 
TYR HH   H N N 375 
TYR HXT  H N N 376 
VAL N    N N N 377 
VAL CA   C N S 378 
VAL C    C N N 379 
VAL O    O N N 380 
VAL CB   C N N 381 
VAL CG1  C N N 382 
VAL CG2  C N N 383 
VAL OXT  O N N 384 
VAL H    H N N 385 
VAL H2   H N N 386 
VAL HA   H N N 387 
VAL HB   H N N 388 
VAL HG11 H N N 389 
VAL HG12 H N N 390 
VAL HG13 H N N 391 
VAL HG21 H N N 392 
VAL HG22 H N N 393 
VAL HG23 H N N 394 
VAL HXT  H N N 395 
YEW CAA  C Y N 396 
YEW CAB  C Y N 397 
YEW CAC  C Y N 398 
YEW CAD  C Y N 399 
YEW CAE  C Y N 400 
YEW CAF  C Y N 401 
YEW CAG  C N N 402 
YEW CAH  C N N 403 
YEW CAJ  C N N 404 
YEW CAK  C N N 405 
YEW CAL  C Y N 406 
YEW CAM  C Y N 407 
YEW CAN  C Y N 408 
YEW CAO  C Y N 409 
YEW CAP  C Y N 410 
YEW CAQ  C Y N 411 
YEW CAR  C N N 412 
YEW CAT  C N N 413 
YEW CAU  C Y N 414 
YEW CAX  C Y N 415 
YEW CAY  C Y N 416 
YEW CAZ  C N N 417 
YEW NAI  N N N 418 
YEW NAS  N N N 419 
YEW NAV  N Y N 420 
YEW NAW  N Y N 421 
YEW OBA  O N N 422 
YEW OBB  O N N 423 
YEW H1   H N N 424 
YEW H2   H N N 425 
YEW H3   H N N 426 
YEW H4   H N N 427 
YEW H5   H N N 428 
YEW H6   H N N 429 
YEW H7   H N N 430 
YEW H8   H N N 431 
YEW H9   H N N 432 
YEW H10  H N N 433 
YEW H11  H N N 434 
YEW H12  H N N 435 
YEW H13  H N N 436 
YEW H14  H N N 437 
YEW H15  H N N 438 
YEW H16  H N N 439 
YEW H17  H N N 440 
YEW H18  H N N 441 
YEW H19  H N N 442 
YEW H20  H N N 443 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
SO4 S   O1   doub N N 290 
SO4 S   O2   doub N N 291 
SO4 S   O3   sing N N 292 
SO4 S   O4   sing N N 293 
THR N   CA   sing N N 294 
THR N   H    sing N N 295 
THR N   H2   sing N N 296 
THR CA  C    sing N N 297 
THR CA  CB   sing N N 298 
THR CA  HA   sing N N 299 
THR C   O    doub N N 300 
THR C   OXT  sing N N 301 
THR CB  OG1  sing N N 302 
THR CB  CG2  sing N N 303 
THR CB  HB   sing N N 304 
THR OG1 HG1  sing N N 305 
THR CG2 HG21 sing N N 306 
THR CG2 HG22 sing N N 307 
THR CG2 HG23 sing N N 308 
THR OXT HXT  sing N N 309 
TRP N   CA   sing N N 310 
TRP N   H    sing N N 311 
TRP N   H2   sing N N 312 
TRP CA  C    sing N N 313 
TRP CA  CB   sing N N 314 
TRP CA  HA   sing N N 315 
TRP C   O    doub N N 316 
TRP C   OXT  sing N N 317 
TRP CB  CG   sing N N 318 
TRP CB  HB2  sing N N 319 
TRP CB  HB3  sing N N 320 
TRP CG  CD1  doub Y N 321 
TRP CG  CD2  sing Y N 322 
TRP CD1 NE1  sing Y N 323 
TRP CD1 HD1  sing N N 324 
TRP CD2 CE2  doub Y N 325 
TRP CD2 CE3  sing Y N 326 
TRP NE1 CE2  sing Y N 327 
TRP NE1 HE1  sing N N 328 
TRP CE2 CZ2  sing Y N 329 
TRP CE3 CZ3  doub Y N 330 
TRP CE3 HE3  sing N N 331 
TRP CZ2 CH2  doub Y N 332 
TRP CZ2 HZ2  sing N N 333 
TRP CZ3 CH2  sing Y N 334 
TRP CZ3 HZ3  sing N N 335 
TRP CH2 HH2  sing N N 336 
TRP OXT HXT  sing N N 337 
TYR N   CA   sing N N 338 
TYR N   H    sing N N 339 
TYR N   H2   sing N N 340 
TYR CA  C    sing N N 341 
TYR CA  CB   sing N N 342 
TYR CA  HA   sing N N 343 
TYR C   O    doub N N 344 
TYR C   OXT  sing N N 345 
TYR CB  CG   sing N N 346 
TYR CB  HB2  sing N N 347 
TYR CB  HB3  sing N N 348 
TYR CG  CD1  doub Y N 349 
TYR CG  CD2  sing Y N 350 
TYR CD1 CE1  sing Y N 351 
TYR CD1 HD1  sing N N 352 
TYR CD2 CE2  doub Y N 353 
TYR CD2 HD2  sing N N 354 
TYR CE1 CZ   doub Y N 355 
TYR CE1 HE1  sing N N 356 
TYR CE2 CZ   sing Y N 357 
TYR CE2 HE2  sing N N 358 
TYR CZ  OH   sing N N 359 
TYR OH  HH   sing N N 360 
TYR OXT HXT  sing N N 361 
VAL N   CA   sing N N 362 
VAL N   H    sing N N 363 
VAL N   H2   sing N N 364 
VAL CA  C    sing N N 365 
VAL CA  CB   sing N N 366 
VAL CA  HA   sing N N 367 
VAL C   O    doub N N 368 
VAL C   OXT  sing N N 369 
VAL CB  CG1  sing N N 370 
VAL CB  CG2  sing N N 371 
VAL CB  HB   sing N N 372 
VAL CG1 HG11 sing N N 373 
VAL CG1 HG12 sing N N 374 
VAL CG1 HG13 sing N N 375 
VAL CG2 HG21 sing N N 376 
VAL CG2 HG22 sing N N 377 
VAL CG2 HG23 sing N N 378 
VAL OXT HXT  sing N N 379 
YEW CAX CAY  sing Y N 380 
YEW CAX NAW  doub Y N 381 
YEW CAY CAU  doub Y N 382 
YEW NAW NAV  sing Y N 383 
YEW CAU NAV  sing Y N 384 
YEW CAU CAA  sing N N 385 
YEW NAV CAZ  sing N N 386 
YEW CAF CAA  doub Y N 387 
YEW CAF CAE  sing Y N 388 
YEW CAA CAB  sing Y N 389 
YEW CAE CAD  doub Y N 390 
YEW CAB CAC  doub Y N 391 
YEW CAD CAC  sing Y N 392 
YEW CAD CAJ  sing N N 393 
YEW CAC CAG  sing N N 394 
YEW OBA CAJ  doub N N 395 
YEW CAJ NAI  sing N N 396 
YEW CAG CAH  doub N N 397 
YEW NAI CAH  sing N N 398 
YEW NAI CAK  sing N N 399 
YEW CAK CAL  sing N N 400 
YEW CAL CAM  doub Y N 401 
YEW CAL CAQ  sing Y N 402 
YEW CAM CAN  sing Y N 403 
YEW CAQ CAP  doub Y N 404 
YEW CAN CAO  doub Y N 405 
YEW NAS CAT  sing N N 406 
YEW NAS CAR  sing N N 407 
YEW CAP CAO  sing Y N 408 
YEW CAP CAR  sing N N 409 
YEW CAR OBB  doub N N 410 
YEW CAB H1   sing N N 411 
YEW CAE H2   sing N N 412 
YEW CAF H3   sing N N 413 
YEW CAG H4   sing N N 414 
YEW CAH H5   sing N N 415 
YEW CAK H6   sing N N 416 
YEW CAK H7   sing N N 417 
YEW CAM H8   sing N N 418 
YEW CAN H9   sing N N 419 
YEW CAO H10  sing N N 420 
YEW CAQ H11  sing N N 421 
YEW CAT H12  sing N N 422 
YEW CAT H13  sing N N 423 
YEW CAT H14  sing N N 424 
YEW CAX H15  sing N N 425 
YEW CAY H16  sing N N 426 
YEW CAZ H17  sing N N 427 
YEW CAZ H18  sing N N 428 
YEW CAZ H19  sing N N 429 
YEW NAS H20  sing N N 430 
# 
_pdbx_audit_support.funding_organization   'National Research Foundation (NRF, Korea)' 
_pdbx_audit_support.country                'Korea, Republic Of' 
_pdbx_audit_support.grant_number           NRF-2023R1A2C1002654 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4L6Q 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8X92 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018613 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007328 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006731 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LYS A 1 3   ? -23.128 11.594  1.410  1.00 102.82 ? 29  LYS A N   1 
ATOM   2    C CA  . LYS A 1 3   ? -22.592 10.241  1.547  1.00 101.87 ? 29  LYS A CA  1 
ATOM   3    C C   . LYS A 1 3   ? -22.985 9.597   2.886  1.00 103.46 ? 29  LYS A C   1 
ATOM   4    O O   . LYS A 1 3   ? -22.649 8.435   3.146  1.00 102.34 ? 29  LYS A O   1 
ATOM   5    C CB  . LYS A 1 3   ? -21.064 10.260  1.397  1.00 102.02 ? 29  LYS A CB  1 
ATOM   6    N N   . LEU A 1 4   ? -23.688 10.361  3.735  1.00 103.15 ? 30  LEU A N   1 
ATOM   7    C CA  . LEU A 1 4   ? -24.126 9.901   5.054  1.00 98.51  ? 30  LEU A CA  1 
ATOM   8    C C   . LEU A 1 4   ? -25.473 9.176   5.045  1.00 98.41  ? 30  LEU A C   1 
ATOM   9    O O   . LEU A 1 4   ? -25.664 8.224   5.817  1.00 97.47  ? 30  LEU A O   1 
ATOM   10   C CB  . LEU A 1 4   ? -24.203 11.085  6.026  1.00 97.12  ? 30  LEU A CB  1 
ATOM   11   C CG  . LEU A 1 4   ? -25.144 10.927  7.232  1.00 93.02  ? 30  LEU A CG  1 
ATOM   12   C CD1 . LEU A 1 4   ? -24.556 9.972   8.258  1.00 94.82  ? 30  LEU A CD1 1 
ATOM   13   C CD2 . LEU A 1 4   ? -25.486 12.264  7.873  1.00 81.95  ? 30  LEU A CD2 1 
ATOM   14   N N   . GLU A 1 5   ? -26.420 9.603   4.197  1.00 95.91  ? 31  GLU A N   1 
ATOM   15   C CA  . GLU A 1 5   ? -27.737 8.966   4.158  1.00 95.01  ? 31  GLU A CA  1 
ATOM   16   C C   . GLU A 1 5   ? -27.671 7.511   3.712  1.00 95.81  ? 31  GLU A C   1 
ATOM   17   O O   . GLU A 1 5   ? -28.667 6.790   3.854  1.00 96.56  ? 31  GLU A O   1 
ATOM   18   C CB  . GLU A 1 5   ? -28.684 9.755   3.250  1.00 93.48  ? 31  GLU A CB  1 
ATOM   19   N N   . ALA A 1 6   ? -26.528 7.068   3.179  1.00 96.67  ? 32  ALA A N   1 
ATOM   20   C CA  . ALA A 1 6   ? -26.323 5.644   2.938  1.00 96.53  ? 32  ALA A CA  1 
ATOM   21   C C   . ALA A 1 6   ? -26.269 4.889   4.258  1.00 93.84  ? 32  ALA A C   1 
ATOM   22   O O   . ALA A 1 6   ? -26.906 3.836   4.409  1.00 91.41  ? 32  ALA A O   1 
ATOM   23   C CB  . ALA A 1 6   ? -25.038 5.418   2.139  1.00 87.68  ? 32  ALA A CB  1 
ATOM   24   N N   . LEU A 1 7   ? -25.523 5.429   5.230  1.00 93.64  ? 33  LEU A N   1 
ATOM   25   C CA  . LEU A 1 7   ? -25.354 4.769   6.518  1.00 92.38  ? 33  LEU A CA  1 
ATOM   26   C C   . LEU A 1 7   ? -26.632 4.767   7.352  1.00 87.83  ? 33  LEU A C   1 
ATOM   27   O O   . LEU A 1 7   ? -26.776 3.909   8.228  1.00 90.45  ? 33  LEU A O   1 
ATOM   28   C CB  . LEU A 1 7   ? -24.246 5.453   7.324  1.00 93.68  ? 33  LEU A CB  1 
ATOM   29   C CG  . LEU A 1 7   ? -22.755 5.213   7.060  1.00 97.30  ? 33  LEU A CG  1 
ATOM   30   C CD1 . LEU A 1 7   ? -21.951 6.315   7.748  1.00 94.52  ? 33  LEU A CD1 1 
ATOM   31   C CD2 . LEU A 1 7   ? -22.288 3.831   7.529  1.00 91.34  ? 33  LEU A CD2 1 
ATOM   32   N N   . ILE A 1 8   ? -27.570 5.688   7.112  1.00 85.61  ? 34  ILE A N   1 
ATOM   33   C CA  . ILE A 1 8   ? -28.832 5.575   7.836  1.00 83.99  ? 34  ILE A CA  1 
ATOM   34   C C   . ILE A 1 8   ? -29.605 4.368   7.329  1.00 82.00  ? 34  ILE A C   1 
ATOM   35   O O   . ILE A 1 8   ? -30.285 3.682   8.105  1.00 79.22  ? 34  ILE A O   1 
ATOM   36   C CB  . ILE A 1 8   ? -29.659 6.867   7.714  1.00 82.82  ? 34  ILE A CB  1 
ATOM   37   C CG1 . ILE A 1 8   ? -28.797 8.094   8.010  1.00 83.57  ? 34  ILE A CG1 1 
ATOM   38   C CG2 . ILE A 1 8   ? -30.831 6.817   8.662  1.00 78.21  ? 34  ILE A CG2 1 
ATOM   39   C CD1 . ILE A 1 8   ? -28.490 8.290   9.464  1.00 85.56  ? 34  ILE A CD1 1 
ATOM   40   N N   . ARG A 1 9   ? -29.493 4.077   6.032  1.00 85.10  ? 35  ARG A N   1 
ATOM   41   C CA  . ARG A 1 9   ? -30.189 2.962   5.403  1.00 85.78  ? 35  ARG A CA  1 
ATOM   42   C C   . ARG A 1 9   ? -29.430 1.642   5.528  1.00 87.60  ? 35  ARG A C   1 
ATOM   43   O O   . ARG A 1 9   ? -30.037 0.575   5.384  1.00 88.64  ? 35  ARG A O   1 
ATOM   44   C CB  . ARG A 1 9   ? -30.442 3.278   3.922  1.00 86.01  ? 35  ARG A CB  1 
ATOM   45   N N   . ASP A 1 10  ? -28.131 1.697   5.812  1.00 84.91  ? 36  ASP A N   1 
ATOM   46   C CA  . ASP A 1 10  ? -27.268 0.518   5.801  1.00 86.03  ? 36  ASP A CA  1 
ATOM   47   C C   . ASP A 1 10  ? -27.484 -0.364  7.030  1.00 86.97  ? 36  ASP A C   1 
ATOM   48   O O   . ASP A 1 10  ? -27.220 0.079   8.153  1.00 83.34  ? 36  ASP A O   1 
ATOM   49   C CB  . ASP A 1 10  ? -25.818 0.975   5.728  1.00 85.65  ? 36  ASP A CB  1 
ATOM   50   C CG  . ASP A 1 10  ? -24.854 -0.166  5.568  1.00 89.54  ? 36  ASP A CG  1 
ATOM   51   O OD1 . ASP A 1 10  ? -25.317 -1.305  5.347  1.00 86.44  ? 36  ASP A OD1 1 
ATOM   52   O OD2 . ASP A 1 10  ? -23.628 0.081   5.655  1.00 94.90  ? 36  ASP A OD2 1 
ATOM   53   N N   . PRO A 1 11  ? -27.904 -1.620  6.864  1.00 88.66  ? 37  PRO A N   1 
ATOM   54   C CA  . PRO A 1 11  ? -28.152 -2.470  8.043  1.00 85.11  ? 37  PRO A CA  1 
ATOM   55   C C   . PRO A 1 11  ? -26.898 -2.850  8.824  1.00 86.09  ? 37  PRO A C   1 
ATOM   56   O O   . PRO A 1 11  ? -27.019 -3.238  9.994  1.00 87.54  ? 37  PRO A O   1 
ATOM   57   C CB  . PRO A 1 11  ? -28.833 -3.710  7.447  1.00 86.26  ? 37  PRO A CB  1 
ATOM   58   C CG  . PRO A 1 11  ? -29.329 -3.270  6.086  1.00 89.01  ? 37  PRO A CG  1 
ATOM   59   C CD  . PRO A 1 11  ? -28.336 -2.263  5.611  1.00 85.92  ? 37  PRO A CD  1 
ATOM   60   N N   . ARG A 1 12  ? -25.709 -2.764  8.231  1.00 85.13  ? 38  ARG A N   1 
ATOM   61   C CA  . ARG A 1 12  ? -24.465 -2.993  8.957  1.00 89.50  ? 38  ARG A CA  1 
ATOM   62   C C   . ARG A 1 12  ? -23.946 -1.716  9.622  1.00 90.45  ? 38  ARG A C   1 
ATOM   63   O O   . ARG A 1 12  ? -22.957 -1.766  10.367 1.00 87.93  ? 38  ARG A O   1 
ATOM   64   C CB  . ARG A 1 12  ? -23.395 -3.584  8.018  1.00 86.87  ? 38  ARG A CB  1 
ATOM   65   N N   . SER A 1 13  ? -24.607 -0.582  9.375  1.00 89.22  ? 39  SER A N   1 
ATOM   66   C CA  . SER A 1 13  ? -24.155 0.709   9.876  1.00 83.79  ? 39  SER A CA  1 
ATOM   67   C C   . SER A 1 13  ? -24.360 0.857   11.383 1.00 86.62  ? 39  SER A C   1 
ATOM   68   O O   . SER A 1 13  ? -25.367 0.389   11.932 1.00 82.61  ? 39  SER A O   1 
ATOM   69   C CB  . SER A 1 13  ? -24.896 1.830   9.172  1.00 84.73  ? 39  SER A CB  1 
ATOM   70   O OG  . SER A 1 13  ? -24.702 3.063   9.845  1.00 81.19  ? 39  SER A OG  1 
ATOM   71   N N   . PRO A 1 14  ? -23.435 1.535   12.071 1.00 86.73  ? 40  PRO A N   1 
ATOM   72   C CA  . PRO A 1 14  ? -23.677 1.906   13.473 1.00 78.98  ? 40  PRO A CA  1 
ATOM   73   C C   . PRO A 1 14  ? -24.742 2.976   13.660 1.00 77.70  ? 40  PRO A C   1 
ATOM   74   O O   . PRO A 1 14  ? -25.227 3.125   14.784 1.00 75.31  ? 40  PRO A O   1 
ATOM   75   C CB  . PRO A 1 14  ? -22.308 2.410   13.941 1.00 81.16  ? 40  PRO A CB  1 
ATOM   76   C CG  . PRO A 1 14  ? -21.647 2.905   12.687 1.00 83.53  ? 40  PRO A CG  1 
ATOM   77   C CD  . PRO A 1 14  ? -22.116 1.994   11.587 1.00 86.34  ? 40  PRO A CD  1 
ATOM   78   N N   . ILE A 1 15  ? -25.146 3.710   12.619 1.00 76.90  ? 41  ILE A N   1 
ATOM   79   C CA  . ILE A 1 15  ? -26.107 4.793   12.823 1.00 76.66  ? 41  ILE A CA  1 
ATOM   80   C C   . ILE A 1 15  ? -27.342 4.669   11.931 1.00 75.24  ? 41  ILE A C   1 
ATOM   81   O O   . ILE A 1 15  ? -27.937 5.684   11.550 1.00 73.82  ? 41  ILE A O   1 
ATOM   82   C CB  . ILE A 1 15  ? -25.432 6.165   12.599 1.00 78.04  ? 41  ILE A CB  1 
ATOM   83   C CG1 . ILE A 1 15  ? -24.919 6.282   11.165 1.00 80.63  ? 41  ILE A CG1 1 
ATOM   84   C CG2 . ILE A 1 15  ? -24.279 6.375   13.569 1.00 78.57  ? 41  ILE A CG2 1 
ATOM   85   C CD1 . ILE A 1 15  ? -24.124 7.533   10.924 1.00 84.80  ? 41  ILE A CD1 1 
ATOM   86   N N   . ASN A 1 16  ? -27.775 3.442   11.638 1.00 75.45  ? 42  ASN A N   1 
ATOM   87   C CA  . ASN A 1 16  ? -29.051 3.253   10.962 1.00 75.60  ? 42  ASN A CA  1 
ATOM   88   C C   . ASN A 1 16  ? -30.211 3.592   11.899 1.00 71.46  ? 42  ASN A C   1 
ATOM   89   O O   . ASN A 1 16  ? -30.033 3.863   13.095 1.00 71.70  ? 42  ASN A O   1 
ATOM   90   C CB  . ASN A 1 16  ? -29.185 1.833   10.423 1.00 75.29  ? 42  ASN A CB  1 
ATOM   91   C CG  . ASN A 1 16  ? -29.024 0.796   11.483 1.00 76.01  ? 42  ASN A CG  1 
ATOM   92   O OD1 . ASN A 1 16  ? -29.827 0.696   12.410 1.00 72.81  ? 42  ASN A OD1 1 
ATOM   93   N ND2 . ASN A 1 16  ? -27.978 0.004   11.357 1.00 84.16  ? 42  ASN A ND2 1 
ATOM   94   N N   . VAL A 1 17  ? -31.422 3.566   11.345 1.00 67.58  ? 43  VAL A N   1 
ATOM   95   C CA  . VAL A 1 17  ? -32.582 3.995   12.125 1.00 67.32  ? 43  VAL A CA  1 
ATOM   96   C C   . VAL A 1 17  ? -32.763 3.121   13.363 1.00 61.01  ? 43  VAL A C   1 
ATOM   97   O O   . VAL A 1 17  ? -33.071 3.619   14.450 1.00 65.38  ? 43  VAL A O   1 
ATOM   98   C CB  . VAL A 1 17  ? -33.844 4.003   11.247 1.00 66.84  ? 43  VAL A CB  1 
ATOM   99   C CG1 . VAL A 1 17  ? -35.107 4.106   12.097 1.00 65.30  ? 43  VAL A CG1 1 
ATOM   100  C CG2 . VAL A 1 17  ? -33.765 5.179   10.287 1.00 62.50  ? 43  VAL A CG2 1 
ATOM   101  N N   . GLU A 1 18  ? -32.484 1.821   13.254 1.00 60.08  ? 44  GLU A N   1 
ATOM   102  C CA  . GLU A 1 18  ? -32.671 0.937   14.414 1.00 68.52  ? 44  GLU A CA  1 
ATOM   103  C C   . GLU A 1 18  ? -31.557 1.036   15.431 1.00 65.42  ? 44  GLU A C   1 
ATOM   104  O O   . GLU A 1 18  ? -31.820 0.830   16.617 1.00 63.82  ? 44  GLU A O   1 
ATOM   105  C CB  . GLU A 1 18  ? -32.928 -0.501  13.956 1.00 65.52  ? 44  GLU A CB  1 
ATOM   106  C CG  . GLU A 1 18  ? -33.946 -0.471  12.887 1.00 78.57  ? 44  GLU A CG  1 
ATOM   107  C CD  . GLU A 1 18  ? -35.295 -0.703  13.571 1.00 89.41  ? 44  GLU A CD  1 
ATOM   108  O OE1 . GLU A 1 18  ? -35.343 -0.515  14.815 1.00 88.62  ? 44  GLU A OE1 1 
ATOM   109  O OE2 . GLU A 1 18  ? -36.311 -0.874  12.869 1.00 96.60  ? 44  GLU A OE2 1 
ATOM   110  N N   . SER A 1 19  ? -30.376 1.525   15.042 1.00 63.94  ? 45  SER A N   1 
ATOM   111  C CA  . SER A 1 19  ? -29.415 1.879   16.085 1.00 63.99  ? 45  SER A CA  1 
ATOM   112  C C   . SER A 1 19  ? -29.800 3.185   16.760 1.00 63.86  ? 45  SER A C   1 
ATOM   113  O O   . SER A 1 19  ? -29.613 3.327   17.972 1.00 60.34  ? 45  SER A O   1 
ATOM   114  C CB  . SER A 1 19  ? -28.009 1.975   15.531 1.00 64.51  ? 45  SER A CB  1 
ATOM   115  O OG  . SER A 1 19  ? -27.554 0.723   15.078 1.00 71.23  ? 45  SER A OG  1 
ATOM   116  N N   . LEU A 1 20  ? -30.315 4.151   15.979 1.00 63.74  ? 46  LEU A N   1 
ATOM   117  C CA  . LEU A 1 20  ? -30.719 5.435   16.544 1.00 64.12  ? 46  LEU A CA  1 
ATOM   118  C C   . LEU A 1 20  ? -31.864 5.267   17.530 1.00 64.94  ? 46  LEU A C   1 
ATOM   119  O O   . LEU A 1 20  ? -31.837 5.850   18.621 1.00 66.77  ? 46  LEU A O   1 
ATOM   120  C CB  . LEU A 1 20  ? -31.102 6.417   15.437 1.00 66.29  ? 46  LEU A CB  1 
ATOM   121  C CG  . LEU A 1 20  ? -29.989 6.832   14.476 1.00 67.89  ? 46  LEU A CG  1 
ATOM   122  C CD1 . LEU A 1 20  ? -30.545 7.745   13.397 1.00 68.95  ? 46  LEU A CD1 1 
ATOM   123  C CD2 . LEU A 1 20  ? -28.850 7.518   15.218 1.00 69.11  ? 46  LEU A CD2 1 
ATOM   124  N N   . LEU A 1 21  ? -32.860 4.447   17.185 1.00 62.68  ? 47  LEU A N   1 
ATOM   125  C CA  . LEU A 1 21  ? -33.935 4.169   18.132 1.00 65.39  ? 47  LEU A CA  1 
ATOM   126  C C   . LEU A 1 21  ? -33.409 3.488   19.393 1.00 64.54  ? 47  LEU A C   1 
ATOM   127  O O   . LEU A 1 21  ? -33.834 3.823   20.507 1.00 61.66  ? 47  LEU A O   1 
ATOM   128  C CB  . LEU A 1 21  ? -35.000 3.306   17.468 1.00 65.06  ? 47  LEU A CB  1 
ATOM   129  C CG  . LEU A 1 21  ? -35.811 4.033   16.409 1.00 70.81  ? 47  LEU A CG  1 
ATOM   130  C CD1 . LEU A 1 21  ? -36.716 3.061   15.653 1.00 72.58  ? 47  LEU A CD1 1 
ATOM   131  C CD2 . LEU A 1 21  ? -36.626 5.135   17.090 1.00 67.35  ? 47  LEU A CD2 1 
ATOM   132  N N   . ASP A 1 22  ? -32.481 2.534   19.243 1.00 61.17  ? 48  ASP A N   1 
ATOM   133  C CA  . ASP A 1 22  ? -31.855 1.926   20.418 1.00 62.67  ? 48  ASP A CA  1 
ATOM   134  C C   . ASP A 1 22  ? -31.292 2.995   21.342 1.00 61.58  ? 48  ASP A C   1 
ATOM   135  O O   . ASP A 1 22  ? -31.457 2.927   22.569 1.00 62.81  ? 48  ASP A O   1 
ATOM   136  C CB  . ASP A 1 22  ? -30.721 0.983   19.999 1.00 65.14  ? 48  ASP A CB  1 
ATOM   137  C CG  . ASP A 1 22  ? -31.198 -0.386  19.535 1.00 63.84  ? 48  ASP A CG  1 
ATOM   138  O OD1 . ASP A 1 22  ? -32.408 -0.726  19.672 1.00 62.81  ? 48  ASP A OD1 1 
ATOM   139  O OD2 . ASP A 1 22  ? -30.325 -1.122  19.010 1.00 57.15  ? 48  ASP A OD2 1 
ATOM   140  N N   . GLY A 1 23  ? -30.624 3.999   20.765 1.00 65.49  ? 49  GLY A N   1 
ATOM   141  C CA  . GLY A 1 23  ? -29.997 5.019   21.589 1.00 65.83  ? 49  GLY A CA  1 
ATOM   142  C C   . GLY A 1 23  ? -31.016 5.850   22.340 1.00 65.18  ? 49  GLY A C   1 
ATOM   143  O O   . GLY A 1 23  ? -30.841 6.146   23.527 1.00 66.13  ? 49  GLY A O   1 
ATOM   144  N N   . LEU A 1 24  ? -32.093 6.234   21.659 1.00 61.51  ? 50  LEU A N   1 
ATOM   145  C CA  . LEU A 1 24  ? -33.180 6.928   22.329 1.00 62.01  ? 50  LEU A CA  1 
ATOM   146  C C   . LEU A 1 24  ? -33.757 6.057   23.432 1.00 66.92  ? 50  LEU A C   1 
ATOM   147  O O   . LEU A 1 24  ? -33.881 6.491   24.582 1.00 68.70  ? 50  LEU A O   1 
ATOM   148  C CB  . LEU A 1 24  ? -34.261 7.296   21.313 1.00 63.33  ? 50  LEU A CB  1 
ATOM   149  C CG  . LEU A 1 24  ? -35.431 8.151   21.790 1.00 69.98  ? 50  LEU A CG  1 
ATOM   150  C CD1 . LEU A 1 24  ? -34.932 9.407   22.518 1.00 69.78  ? 50  LEU A CD1 1 
ATOM   151  C CD2 . LEU A 1 24  ? -36.280 8.528   20.596 1.00 67.99  ? 50  LEU A CD2 1 
ATOM   152  N N   . ASN A 1 25  ? -34.067 4.800   23.104 1.00 66.88  ? 51  ASN A N   1 
ATOM   153  C CA  . ASN A 1 25  ? -34.723 3.918   24.058 1.00 67.32  ? 51  ASN A CA  1 
ATOM   154  C C   . ASN A 1 25  ? -33.862 3.674   25.286 1.00 69.73  ? 51  ASN A C   1 
ATOM   155  O O   . ASN A 1 25  ? -34.372 3.615   26.410 1.00 68.60  ? 51  ASN A O   1 
ATOM   156  C CB  . ASN A 1 25  ? -35.054 2.593   23.390 1.00 68.31  ? 51  ASN A CB  1 
ATOM   157  C CG  . ASN A 1 25  ? -36.525 2.433   23.147 1.00 80.66  ? 51  ASN A CG  1 
ATOM   158  O OD1 . ASN A 1 25  ? -37.310 2.341   24.097 1.00 80.60  ? 51  ASN A OD1 1 
ATOM   159  N ND2 . ASN A 1 25  ? -36.919 2.401   21.875 1.00 81.34  ? 51  ASN A ND2 1 
ATOM   160  N N   . SER A 1 26  ? -32.557 3.525   25.099 1.00 67.52  ? 52  SER A N   1 
ATOM   161  C CA  . SER A 1 26  ? -31.725 3.221   26.256 1.00 69.67  ? 52  SER A CA  1 
ATOM   162  C C   . SER A 1 26  ? -31.466 4.464   27.093 1.00 71.27  ? 52  SER A C   1 
ATOM   163  O O   . SER A 1 26  ? -31.221 4.360   28.305 1.00 71.37  ? 52  SER A O   1 
ATOM   164  C CB  . SER A 1 26  ? -30.410 2.589   25.812 1.00 69.60  ? 52  SER A CB  1 
ATOM   165  O OG  . SER A 1 26  ? -29.621 3.549   25.162 1.00 72.53  ? 52  SER A OG  1 
ATOM   166  N N   . LEU A 1 27  ? -31.486 5.640   26.459 1.00 71.61  ? 53  LEU A N   1 
ATOM   167  C CA  . LEU A 1 27  ? -31.423 6.890   27.206 1.00 67.80  ? 53  LEU A CA  1 
ATOM   168  C C   . LEU A 1 27  ? -32.608 7.009   28.154 1.00 74.43  ? 53  LEU A C   1 
ATOM   169  O O   . LEU A 1 27  ? -32.448 7.346   29.332 1.00 76.29  ? 53  LEU A O   1 
ATOM   170  C CB  . LEU A 1 27  ? -31.392 8.061   26.235 1.00 71.21  ? 53  LEU A CB  1 
ATOM   171  C CG  . LEU A 1 27  ? -30.874 9.378   26.781 1.00 75.44  ? 53  LEU A CG  1 
ATOM   172  C CD1 . LEU A 1 27  ? -29.686 9.118   27.650 1.00 77.64  ? 53  LEU A CD1 1 
ATOM   173  C CD2 . LEU A 1 27  ? -30.479 10.253  25.609 1.00 81.54  ? 53  LEU A CD2 1 
ATOM   174  N N   . VAL A 1 28  ? -33.810 6.712   27.666 1.00 65.32  ? 54  VAL A N   1 
ATOM   175  C CA  . VAL A 1 28  ? -34.979 6.788   28.529 1.00 69.95  ? 54  VAL A CA  1 
ATOM   176  C C   . VAL A 1 28  ? -34.884 5.762   29.649 1.00 75.77  ? 54  VAL A C   1 
ATOM   177  O O   . VAL A 1 28  ? -35.230 6.045   30.802 1.00 75.93  ? 54  VAL A O   1 
ATOM   178  C CB  . VAL A 1 28  ? -36.263 6.611   27.702 1.00 70.19  ? 54  VAL A CB  1 
ATOM   179  C CG1 . VAL A 1 28  ? -37.467 6.392   28.613 1.00 70.04  ? 54  VAL A CG1 1 
ATOM   180  C CG2 . VAL A 1 28  ? -36.451 7.819   26.816 1.00 69.88  ? 54  VAL A CG2 1 
ATOM   181  N N   . LEU A 1 29  ? -34.401 4.558   29.340 1.00 72.63  ? 55  LEU A N   1 
ATOM   182  C CA  . LEU A 1 29  ? -34.351 3.532   30.374 1.00 73.96  ? 55  LEU A CA  1 
ATOM   183  C C   . LEU A 1 29  ? -33.279 3.839   31.416 1.00 75.88  ? 55  LEU A C   1 
ATOM   184  O O   . LEU A 1 29  ? -33.476 3.557   32.602 1.00 78.01  ? 55  LEU A O   1 
ATOM   185  C CB  . LEU A 1 29  ? -34.113 2.156   29.744 1.00 72.11  ? 55  LEU A CB  1 
ATOM   186  C CG  . LEU A 1 29  ? -35.295 1.562   28.972 1.00 78.50  ? 55  LEU A CG  1 
ATOM   187  C CD1 . LEU A 1 29  ? -34.845 0.516   27.924 1.00 70.03  ? 55  LEU A CD1 1 
ATOM   188  C CD2 . LEU A 1 29  ? -36.302 0.970   29.943 1.00 71.82  ? 55  LEU A CD2 1 
ATOM   189  N N   . ASP A 1 30  ? -32.155 4.428   31.010 1.00 76.25  ? 56  ASP A N   1 
ATOM   190  C CA  . ASP A 1 30  ? -31.072 4.670   31.959 1.00 76.40  ? 56  ASP A CA  1 
ATOM   191  C C   . ASP A 1 30  ? -31.252 5.932   32.796 1.00 80.24  ? 56  ASP A C   1 
ATOM   192  O O   . ASP A 1 30  ? -30.430 6.174   33.690 1.00 80.81  ? 56  ASP A O   1 
ATOM   193  C CB  . ASP A 1 30  ? -29.735 4.736   31.229 1.00 69.01  ? 56  ASP A CB  1 
ATOM   194  C CG  . ASP A 1 30  ? -29.119 3.359   31.031 1.00 78.57  ? 56  ASP A CG  1 
ATOM   195  O OD1 . ASP A 1 30  ? -29.357 2.465   31.880 1.00 82.89  ? 56  ASP A OD1 1 
ATOM   196  O OD2 . ASP A 1 30  ? -28.416 3.161   30.017 1.00 79.94  ? 56  ASP A OD2 1 
ATOM   197  N N   . LEU A 1 31  ? -32.302 6.721   32.557 1.00 75.54  ? 57  LEU A N   1 
ATOM   198  C CA  . LEU A 1 31  ? -32.541 7.933   33.327 1.00 80.31  ? 57  LEU A CA  1 
ATOM   199  C C   . LEU A 1 31  ? -33.860 7.943   34.075 1.00 83.78  ? 57  LEU A C   1 
ATOM   200  O O   . LEU A 1 31  ? -33.980 8.681   35.054 1.00 88.41  ? 57  LEU A O   1 
ATOM   201  C CB  . LEU A 1 31  ? -32.521 9.173   32.422 1.00 74.44  ? 57  LEU A CB  1 
ATOM   202  C CG  . LEU A 1 31  ? -31.344 9.465   31.509 1.00 74.58  ? 57  LEU A CG  1 
ATOM   203  C CD1 . LEU A 1 31  ? -31.806 10.418  30.428 1.00 73.39  ? 57  LEU A CD1 1 
ATOM   204  C CD2 . LEU A 1 31  ? -30.179 10.041  32.284 1.00 76.74  ? 57  LEU A CD2 1 
ATOM   205  N N   . ASP A 1 32  ? -34.842 7.151   33.655 1.00 83.50  ? 58  ASP A N   1 
ATOM   206  C CA  . ASP A 1 32  ? -36.180 7.195   34.243 1.00 89.75  ? 58  ASP A CA  1 
ATOM   207  C C   . ASP A 1 32  ? -36.195 6.506   35.605 1.00 90.94  ? 58  ASP A C   1 
ATOM   208  O O   . ASP A 1 32  ? -36.666 5.379   35.773 1.00 92.96  ? 58  ASP A O   1 
ATOM   209  C CB  . ASP A 1 32  ? -37.196 6.570   33.307 1.00 90.09  ? 58  ASP A CB  1 
ATOM   210  C CG  . ASP A 1 32  ? -38.597 6.800   33.776 1.00 97.68  ? 58  ASP A CG  1 
ATOM   211  O OD1 . ASP A 1 32  ? -39.011 7.979   33.814 1.00 101.45 ? 58  ASP A OD1 1 
ATOM   212  O OD2 . ASP A 1 32  ? -39.267 5.809   34.136 1.00 100.66 ? 58  ASP A OD2 1 
ATOM   213  N N   . PHE A 1 33  ? -35.653 7.203   36.595 1.00 93.85  ? 59  PHE A N   1 
ATOM   214  C CA  . PHE A 1 33  ? -35.689 6.777   37.986 1.00 98.24  ? 59  PHE A CA  1 
ATOM   215  C C   . PHE A 1 33  ? -35.932 8.001   38.857 1.00 100.87 ? 59  PHE A C   1 
ATOM   216  O O   . PHE A 1 33  ? -35.513 9.113   38.502 1.00 97.17  ? 59  PHE A O   1 
ATOM   217  C CB  . PHE A 1 33  ? -34.392 6.064   38.409 1.00 93.13  ? 59  PHE A CB  1 
ATOM   218  C CG  . PHE A 1 33  ? -34.117 4.809   37.628 1.00 94.57  ? 59  PHE A CG  1 
ATOM   219  C CD1 . PHE A 1 33  ? -34.787 3.632   37.921 1.00 95.83  ? 59  PHE A CD1 1 
ATOM   220  C CD2 . PHE A 1 33  ? -33.205 4.814   36.583 1.00 91.88  ? 59  PHE A CD2 1 
ATOM   221  C CE1 . PHE A 1 33  ? -34.540 2.478   37.192 1.00 96.37  ? 59  PHE A CE1 1 
ATOM   222  C CE2 . PHE A 1 33  ? -32.955 3.665   35.848 1.00 90.47  ? 59  PHE A CE2 1 
ATOM   223  C CZ  . PHE A 1 33  ? -33.620 2.496   36.155 1.00 91.65  ? 59  PHE A CZ  1 
ATOM   224  N N   . PRO A 1 34  ? -36.630 7.832   39.990 1.00 103.16 ? 60  PRO A N   1 
ATOM   225  C CA  . PRO A 1 34  ? -36.921 8.998   40.843 1.00 99.30  ? 60  PRO A CA  1 
ATOM   226  C C   . PRO A 1 34  ? -35.671 9.743   41.274 1.00 98.56  ? 60  PRO A C   1 
ATOM   227  O O   . PRO A 1 34  ? -35.648 10.981  41.245 1.00 95.96  ? 60  PRO A O   1 
ATOM   228  C CB  . PRO A 1 34  ? -37.656 8.376   42.042 1.00 100.96 ? 60  PRO A CB  1 
ATOM   229  C CG  . PRO A 1 34  ? -38.215 7.092   41.520 1.00 104.82 ? 60  PRO A CG  1 
ATOM   230  C CD  . PRO A 1 34  ? -37.215 6.589   40.525 1.00 102.32 ? 60  PRO A CD  1 
ATOM   231  N N   . ALA A 1 35  ? -34.614 9.015   41.640 1.00 96.07  ? 61  ALA A N   1 
ATOM   232  C CA  . ALA A 1 35  ? -33.383 9.662   42.078 1.00 93.43  ? 61  ALA A CA  1 
ATOM   233  C C   . ALA A 1 35  ? -32.842 10.601  41.003 1.00 98.46  ? 61  ALA A C   1 
ATOM   234  O O   . ALA A 1 35  ? -32.437 11.731  41.297 1.00 98.00  ? 61  ALA A O   1 
ATOM   235  C CB  . ALA A 1 35  ? -32.345 8.603   42.449 1.00 95.16  ? 61  ALA A CB  1 
ATOM   236  N N   . LEU A 1 36  ? -32.837 10.151  39.742 1.00 99.35  ? 62  LEU A N   1 
ATOM   237  C CA  . LEU A 1 36  ? -32.272 10.947  38.661 1.00 93.38  ? 62  LEU A CA  1 
ATOM   238  C C   . LEU A 1 36  ? -33.218 12.025  38.147 1.00 93.89  ? 62  LEU A C   1 
ATOM   239  O O   . LEU A 1 36  ? -32.748 12.975  37.505 1.00 88.10  ? 62  LEU A O   1 
ATOM   240  C CB  . LEU A 1 36  ? -31.812 10.047  37.512 1.00 93.13  ? 62  LEU A CB  1 
ATOM   241  C CG  . LEU A 1 36  ? -30.702 9.050   37.879 1.00 90.29  ? 62  LEU A CG  1 
ATOM   242  C CD1 . LEU A 1 36  ? -31.297 7.699   38.193 1.00 93.03  ? 62  LEU A CD1 1 
ATOM   243  C CD2 . LEU A 1 36  ? -29.642 8.929   36.785 1.00 86.87  ? 62  LEU A CD2 1 
ATOM   244  N N   . ARG A 1 37  ? -34.523 11.931  38.431 1.00 96.72  ? 63  ARG A N   1 
ATOM   245  C CA  . ARG A 1 37  ? -35.446 12.978  38.002 1.00 98.97  ? 63  ARG A CA  1 
ATOM   246  C C   . ARG A 1 37  ? -35.478 14.181  38.945 1.00 100.51 ? 63  ARG A C   1 
ATOM   247  O O   . ARG A 1 37  ? -36.278 15.100  38.718 1.00 99.29  ? 63  ARG A O   1 
ATOM   248  C CB  . ARG A 1 37  ? -36.879 12.445  37.885 1.00 101.26 ? 63  ARG A CB  1 
ATOM   249  C CG  . ARG A 1 37  ? -37.358 11.984  36.517 1.00 102.12 ? 63  ARG A CG  1 
ATOM   250  C CD  . ARG A 1 37  ? -38.717 11.319  36.695 1.00 106.94 ? 63  ARG A CD  1 
ATOM   251  N NE  . ARG A 1 37  ? -39.191 10.492  35.584 1.00 111.34 ? 63  ARG A NE  1 
ATOM   252  C CZ  . ARG A 1 37  ? -39.889 10.923  34.526 1.00 110.90 ? 63  ARG A CZ  1 
ATOM   253  N NH1 . ARG A 1 37  ? -40.220 12.204  34.381 1.00 110.56 ? 63  ARG A NH1 1 
ATOM   254  N NH2 . ARG A 1 37  ? -40.257 10.055  33.588 1.00 106.99 ? 63  ARG A NH2 1 
ATOM   255  N N   . LYS A 1 38  ? -34.578 14.243  39.931 1.00 99.08  ? 64  LYS A N   1 
ATOM   256  C CA  . LYS A 1 38  ? -34.368 15.475  40.682 1.00 98.65  ? 64  LYS A CA  1 
ATOM   257  C C   . LYS A 1 38  ? -33.527 16.467  39.895 1.00 100.62 ? 64  LYS A C   1 
ATOM   258  O O   . LYS A 1 38  ? -33.622 17.677  40.128 1.00 103.35 ? 64  LYS A O   1 
ATOM   259  C CB  . LYS A 1 38  ? -33.699 15.169  42.029 1.00 93.59  ? 64  LYS A CB  1 
ATOM   260  N N   . ASN A 1 39  ? -32.702 15.972  38.980 1.00 94.17  ? 65  ASN A N   1 
ATOM   261  C CA  . ASN A 1 39  ? -32.153 16.801  37.922 1.00 89.94  ? 65  ASN A CA  1 
ATOM   262  C C   . ASN A 1 39  ? -33.291 17.241  36.998 1.00 93.18  ? 65  ASN A C   1 
ATOM   263  O O   . ASN A 1 39  ? -34.157 16.435  36.641 1.00 93.72  ? 65  ASN A O   1 
ATOM   264  C CB  . ASN A 1 39  ? -31.085 16.013  37.166 1.00 88.77  ? 65  ASN A CB  1 
ATOM   265  C CG  . ASN A 1 39  ? -30.334 16.846  36.164 1.00 84.89  ? 65  ASN A CG  1 
ATOM   266  O OD1 . ASN A 1 39  ? -30.910 17.697  35.494 1.00 85.52  ? 65  ASN A OD1 1 
ATOM   267  N ND2 . ASN A 1 39  ? -29.034 16.591  36.041 1.00 83.04  ? 65  ASN A ND2 1 
ATOM   268  N N   . LYS A 1 40  ? -33.336 18.539  36.674 1.00 91.15  ? 66  LYS A N   1 
ATOM   269  C CA  . LYS A 1 40  ? -34.405 19.069  35.829 1.00 90.44  ? 66  LYS A CA  1 
ATOM   270  C C   . LYS A 1 40  ? -34.101 18.895  34.344 1.00 90.06  ? 66  LYS A C   1 
ATOM   271  O O   . LYS A 1 40  ? -35.025 18.735  33.539 1.00 89.77  ? 66  LYS A O   1 
ATOM   272  C CB  . LYS A 1 40  ? -34.649 20.549  36.142 1.00 85.36  ? 66  LYS A CB  1 
ATOM   273  N N   . ASN A 1 41  ? -32.823 18.943  33.965 1.00 87.26  ? 67  ASN A N   1 
ATOM   274  C CA  . ASN A 1 41  ? -32.442 18.566  32.611 1.00 85.89  ? 67  ASN A CA  1 
ATOM   275  C C   . ASN A 1 41  ? -32.987 17.191  32.268 1.00 86.74  ? 67  ASN A C   1 
ATOM   276  O O   . ASN A 1 41  ? -33.659 17.011  31.244 1.00 88.85  ? 67  ASN A O   1 
ATOM   277  C CB  . ASN A 1 41  ? -30.925 18.581  32.470 1.00 81.55  ? 67  ASN A CB  1 
ATOM   278  C CG  . ASN A 1 41  ? -30.376 19.960  32.516 1.00 82.62  ? 67  ASN A CG  1 
ATOM   279  O OD1 . ASN A 1 41  ? -31.146 20.917  32.522 1.00 81.85  ? 67  ASN A OD1 1 
ATOM   280  N ND2 . ASN A 1 41  ? -29.041 20.092  32.539 1.00 82.60  ? 67  ASN A ND2 1 
ATOM   281  N N   . ILE A 1 42  ? -32.737 16.220  33.148 1.00 84.72  ? 68  ILE A N   1 
ATOM   282  C CA  . ILE A 1 42  ? -33.190 14.854  32.920 1.00 87.96  ? 68  ILE A CA  1 
ATOM   283  C C   . ILE A 1 42  ? -34.709 14.812  32.826 1.00 90.59  ? 68  ILE A C   1 
ATOM   284  O O   . ILE A 1 42  ? -35.274 14.191  31.918 1.00 92.04  ? 68  ILE A O   1 
ATOM   285  C CB  . ILE A 1 42  ? -32.651 13.926  34.022 1.00 85.15  ? 68  ILE A CB  1 
ATOM   286  C CG1 . ILE A 1 42  ? -31.149 13.715  33.812 1.00 83.32  ? 68  ILE A CG1 1 
ATOM   287  C CG2 . ILE A 1 42  ? -33.410 12.616  34.038 1.00 81.87  ? 68  ILE A CG2 1 
ATOM   288  C CD1 . ILE A 1 42  ? -30.495 12.793  34.821 1.00 83.50  ? 68  ILE A CD1 1 
ATOM   289  N N   . ASP A 1 43  ? -35.396 15.487  33.747 1.00 92.99  ? 69  ASP A N   1 
ATOM   290  C CA  . ASP A 1 43  ? -36.851 15.471  33.666 1.00 94.24  ? 69  ASP A CA  1 
ATOM   291  C C   . ASP A 1 43  ? -37.339 16.290  32.478 1.00 93.50  ? 69  ASP A C   1 
ATOM   292  O O   . ASP A 1 43  ? -38.362 15.950  31.871 1.00 96.02  ? 69  ASP A O   1 
ATOM   293  C CB  . ASP A 1 43  ? -37.488 15.967  34.960 1.00 95.85  ? 69  ASP A CB  1 
ATOM   294  C CG  . ASP A 1 43  ? -38.874 15.361  35.186 1.00 105.21 ? 69  ASP A CG  1 
ATOM   295  O OD1 . ASP A 1 43  ? -39.650 15.266  34.204 1.00 105.81 ? 69  ASP A OD1 1 
ATOM   296  O OD2 . ASP A 1 43  ? -39.181 14.948  36.329 1.00 103.25 ? 69  ASP A OD2 1 
ATOM   297  N N   . ASN A 1 44  ? -36.623 17.356  32.112 1.00 91.91  ? 70  ASN A N   1 
ATOM   298  C CA  . ASN A 1 44  ? -37.023 18.099  30.922 1.00 93.94  ? 70  ASN A CA  1 
ATOM   299  C C   . ASN A 1 44  ? -36.999 17.202  29.690 1.00 96.00  ? 70  ASN A C   1 
ATOM   300  O O   . ASN A 1 44  ? -37.810 17.383  28.772 1.00 94.72  ? 70  ASN A O   1 
ATOM   301  C CB  . ASN A 1 44  ? -36.114 19.312  30.712 1.00 90.48  ? 70  ASN A CB  1 
ATOM   302  N N   . PHE A 1 45  ? -36.086 16.222  29.659 1.00 95.57  ? 71  PHE A N   1 
ATOM   303  C CA  . PHE A 1 45  ? -36.040 15.253  28.565 1.00 90.25  ? 71  PHE A CA  1 
ATOM   304  C C   . PHE A 1 45  ? -37.120 14.192  28.700 1.00 88.51  ? 71  PHE A C   1 
ATOM   305  O O   . PHE A 1 45  ? -37.832 13.897  27.734 1.00 88.53  ? 71  PHE A O   1 
ATOM   306  C CB  . PHE A 1 45  ? -34.645 14.618  28.479 1.00 86.91  ? 71  PHE A CB  1 
ATOM   307  C CG  . PHE A 1 45  ? -34.547 13.472  27.505 1.00 84.39  ? 71  PHE A CG  1 
ATOM   308  C CD1 . PHE A 1 45  ? -34.429 13.704  26.142 1.00 81.72  ? 71  PHE A CD1 1 
ATOM   309  C CD2 . PHE A 1 45  ? -34.559 12.159  27.958 1.00 80.60  ? 71  PHE A CD2 1 
ATOM   310  C CE1 . PHE A 1 45  ? -34.332 12.646  25.249 1.00 78.12  ? 71  PHE A CE1 1 
ATOM   311  C CE2 . PHE A 1 45  ? -34.465 11.096  27.075 1.00 75.65  ? 71  PHE A CE2 1 
ATOM   312  C CZ  . PHE A 1 45  ? -34.350 11.338  25.721 1.00 79.53  ? 71  PHE A CZ  1 
ATOM   313  N N   . LEU A 1 46  ? -37.259 13.613  29.891 1.00 86.80  ? 72  LEU A N   1 
ATOM   314  C CA  . LEU A 1 46  ? -38.254 12.568  30.074 1.00 88.92  ? 72  LEU A CA  1 
ATOM   315  C C   . LEU A 1 46  ? -39.660 13.087  29.819 1.00 94.33  ? 72  LEU A C   1 
ATOM   316  O O   . LEU A 1 46  ? -40.507 12.344  29.318 1.00 94.65  ? 72  LEU A O   1 
ATOM   317  C CB  . LEU A 1 46  ? -38.130 11.977  31.467 1.00 90.52  ? 72  LEU A CB  1 
ATOM   318  C CG  . LEU A 1 46  ? -36.892 11.100  31.658 1.00 91.41  ? 72  LEU A CG  1 
ATOM   319  C CD1 . LEU A 1 46  ? -36.755 10.682  33.120 1.00 93.04  ? 72  LEU A CD1 1 
ATOM   320  C CD2 . LEU A 1 46  ? -36.929 9.877   30.733 1.00 83.70  ? 72  LEU A CD2 1 
ATOM   321  N N   . ASN A 1 47  ? -39.931 14.354  30.151 1.00 96.57  ? 73  ASN A N   1 
ATOM   322  C CA  . ASN A 1 47  ? -41.242 14.927  29.857 1.00 96.61  ? 73  ASN A CA  1 
ATOM   323  C C   . ASN A 1 47  ? -41.500 14.928  28.364 1.00 92.94  ? 73  ASN A C   1 
ATOM   324  O O   . ASN A 1 47  ? -42.542 14.466  27.888 1.00 92.93  ? 73  ASN A O   1 
ATOM   325  C CB  . ASN A 1 47  ? -41.316 16.362  30.365 1.00 99.88  ? 73  ASN A CB  1 
ATOM   326  C CG  . ASN A 1 47  ? -41.426 16.436  31.848 1.00 99.68  ? 73  ASN A CG  1 
ATOM   327  O OD1 . ASN A 1 47  ? -41.796 15.455  32.499 1.00 99.41  ? 73  ASN A OD1 1 
ATOM   328  N ND2 . ASN A 1 47  ? -41.110 17.604  32.408 1.00 97.41  ? 73  ASN A ND2 1 
ATOM   329  N N   . ARG A 1 48  ? -40.530 15.422  27.607 1.00 91.65  ? 74  ARG A N   1 
ATOM   330  C CA  . ARG A 1 48  ? -40.695 15.546  26.169 1.00 91.67  ? 74  ARG A CA  1 
ATOM   331  C C   . ARG A 1 48  ? -40.834 14.219  25.456 1.00 89.66  ? 74  ARG A C   1 
ATOM   332  O O   . ARG A 1 48  ? -41.556 14.131  24.457 1.00 86.31  ? 74  ARG A O   1 
ATOM   333  C CB  . ARG A 1 48  ? -39.521 16.283  25.607 1.00 94.37  ? 74  ARG A CB  1 
ATOM   334  C CG  . ARG A 1 48  ? -39.687 17.725  25.782 1.00 96.79  ? 74  ARG A CG  1 
ATOM   335  C CD  . ARG A 1 48  ? -38.332 18.315  25.692 1.00 95.34  ? 74  ARG A CD  1 
ATOM   336  N NE  . ARG A 1 48  ? -37.279 17.501  26.292 1.00 98.67  ? 74  ARG A NE  1 
ATOM   337  C CZ  . ARG A 1 48  ? -36.002 17.887  26.231 1.00 100.41 ? 74  ARG A CZ  1 
ATOM   338  N NH1 . ARG A 1 48  ? -35.771 19.009  25.561 1.00 92.26  ? 74  ARG A NH1 1 
ATOM   339  N NH2 . ARG A 1 48  ? -34.973 17.206  26.808 1.00 100.02 ? 74  ARG A NH2 1 
ATOM   340  N N   . TYR A 1 49  ? -40.105 13.194  25.895 1.00 86.62  ? 75  TYR A N   1 
ATOM   341  C CA  . TYR A 1 49  ? -39.973 11.999  25.078 1.00 85.03  ? 75  TYR A CA  1 
ATOM   342  C C   . TYR A 1 49  ? -40.571 10.739  25.684 1.00 82.91  ? 75  TYR A C   1 
ATOM   343  O O   . TYR A 1 49  ? -40.742 9.764   24.949 1.00 84.32  ? 75  TYR A O   1 
ATOM   344  C CB  . TYR A 1 49  ? -38.499 11.740  24.728 1.00 78.59  ? 75  TYR A CB  1 
ATOM   345  C CG  . TYR A 1 49  ? -38.086 12.547  23.529 1.00 81.59  ? 75  TYR A CG  1 
ATOM   346  C CD1 . TYR A 1 49  ? -38.444 12.155  22.245 1.00 79.63  ? 75  TYR A CD1 1 
ATOM   347  C CD2 . TYR A 1 49  ? -37.401 13.745  23.684 1.00 82.87  ? 75  TYR A CD2 1 
ATOM   348  C CE1 . TYR A 1 49  ? -38.096 12.915  21.153 1.00 79.11  ? 75  TYR A CE1 1 
ATOM   349  C CE2 . TYR A 1 49  ? -37.045 14.510  22.596 1.00 80.06  ? 75  TYR A CE2 1 
ATOM   350  C CZ  . TYR A 1 49  ? -37.394 14.089  21.336 1.00 80.37  ? 75  TYR A CZ  1 
ATOM   351  O OH  . TYR A 1 49  ? -37.032 14.856  20.257 1.00 85.99  ? 75  TYR A OH  1 
ATOM   352  N N   . GLU A 1 50  ? -40.889 10.716  26.984 1.00 81.03  ? 76  GLU A N   1 
ATOM   353  C CA  . GLU A 1 50  ? -41.226 9.438   27.614 1.00 81.99  ? 76  GLU A CA  1 
ATOM   354  C C   . GLU A 1 50  ? -42.487 8.835   27.023 1.00 82.26  ? 76  GLU A C   1 
ATOM   355  O O   . GLU A 1 50  ? -42.632 7.608   27.004 1.00 87.25  ? 76  GLU A O   1 
ATOM   356  C CB  . GLU A 1 50  ? -41.378 9.582   29.132 1.00 81.51  ? 76  GLU A CB  1 
ATOM   357  N N   . LYS A 1 51  ? -43.401 9.664   26.524 1.00 79.58  ? 77  LYS A N   1 
ATOM   358  C CA  . LYS A 1 51  ? -44.668 9.147   26.023 1.00 77.35  ? 77  LYS A CA  1 
ATOM   359  C C   . LYS A 1 51  ? -44.590 8.666   24.574 1.00 83.17  ? 77  LYS A C   1 
ATOM   360  O O   . LYS A 1 51  ? -45.339 7.759   24.197 1.00 85.12  ? 77  LYS A O   1 
ATOM   361  C CB  . LYS A 1 51  ? -45.756 10.213  26.173 1.00 71.63  ? 77  LYS A CB  1 
ATOM   362  N N   . ILE A 1 52  ? -43.702 9.222   23.744 1.00 76.53  ? 78  ILE A N   1 
ATOM   363  C CA  . ILE A 1 52  ? -43.586 8.667   22.396 1.00 82.45  ? 78  ILE A CA  1 
ATOM   364  C C   . ILE A 1 52  ? -42.658 7.452   22.399 1.00 80.40  ? 78  ILE A C   1 
ATOM   365  O O   . ILE A 1 52  ? -42.883 6.493   21.651 1.00 77.15  ? 78  ILE A O   1 
ATOM   366  C CB  . ILE A 1 52  ? -43.119 9.728   21.382 1.00 81.19  ? 78  ILE A CB  1 
ATOM   367  C CG1 . ILE A 1 52  ? -43.057 9.115   19.978 1.00 85.40  ? 78  ILE A CG1 1 
ATOM   368  C CG2 . ILE A 1 52  ? -41.758 10.305  21.773 1.00 81.28  ? 78  ILE A CG2 1 
ATOM   369  C CD1 . ILE A 1 52  ? -43.525 10.023  18.873 1.00 87.18  ? 78  ILE A CD1 1 
ATOM   370  N N   . VAL A 1 53  ? -41.645 7.448   23.271 1.00 81.07  ? 79  VAL A N   1 
ATOM   371  C CA  . VAL A 1 53  ? -40.773 6.287   23.410 1.00 79.97  ? 79  VAL A CA  1 
ATOM   372  C C   . VAL A 1 53  ? -41.572 5.084   23.890 1.00 81.81  ? 79  VAL A C   1 
ATOM   373  O O   . VAL A 1 53  ? -41.313 3.948   23.477 1.00 84.07  ? 79  VAL A O   1 
ATOM   374  C CB  . VAL A 1 53  ? -39.600 6.634   24.356 1.00 81.41  ? 79  VAL A CB  1 
ATOM   375  C CG1 . VAL A 1 53  ? -38.915 5.382   24.887 1.00 75.49  ? 79  VAL A CG1 1 
ATOM   376  C CG2 . VAL A 1 53  ? -38.588 7.537   23.643 1.00 77.67  ? 79  VAL A CG2 1 
ATOM   377  N N   . LYS A 1 54  ? -42.576 5.307   24.737 1.00 85.03  ? 80  LYS A N   1 
ATOM   378  C CA  . LYS A 1 54  ? -43.422 4.192   25.149 1.00 84.27  ? 80  LYS A CA  1 
ATOM   379  C C   . LYS A 1 54  ? -44.319 3.729   24.010 1.00 84.16  ? 80  LYS A C   1 
ATOM   380  O O   . LYS A 1 54  ? -44.655 2.543   23.935 1.00 88.16  ? 80  LYS A O   1 
ATOM   381  C CB  . LYS A 1 54  ? -44.257 4.577   26.370 1.00 82.94  ? 80  LYS A CB  1 
ATOM   382  N N   . LYS A 1 55  ? -44.715 4.639   23.114 1.00 82.55  ? 81  LYS A N   1 
ATOM   383  C CA  . LYS A 1 55  ? -45.549 4.234   21.986 1.00 79.81  ? 81  LYS A CA  1 
ATOM   384  C C   . LYS A 1 55  ? -44.749 3.433   20.966 1.00 83.89  ? 81  LYS A C   1 
ATOM   385  O O   . LYS A 1 55  ? -45.219 2.402   20.468 1.00 83.71  ? 81  LYS A O   1 
ATOM   386  C CB  . LYS A 1 55  ? -46.173 5.459   21.320 1.00 79.39  ? 81  LYS A CB  1 
ATOM   387  N N   . ILE A 1 56  ? -43.527 3.870   20.656 1.00 81.69  ? 82  ILE A N   1 
ATOM   388  C CA  . ILE A 1 56  ? -42.748 3.134   19.669 1.00 83.28  ? 82  ILE A CA  1 
ATOM   389  C C   . ILE A 1 56  ? -42.292 1.804   20.238 1.00 82.21  ? 82  ILE A C   1 
ATOM   390  O O   . ILE A 1 56  ? -42.120 0.834   19.492 1.00 82.40  ? 82  ILE A O   1 
ATOM   391  C CB  . ILE A 1 56  ? -41.571 3.976   19.149 1.00 85.63  ? 82  ILE A CB  1 
ATOM   392  C CG1 . ILE A 1 56  ? -40.492 4.143   20.213 1.00 84.60  ? 82  ILE A CG1 1 
ATOM   393  C CG2 . ILE A 1 56  ? -42.078 5.321   18.680 1.00 88.21  ? 82  ILE A CG2 1 
ATOM   394  C CD1 . ILE A 1 56  ? -39.440 5.184   19.831 1.00 83.95  ? 82  ILE A CD1 1 
ATOM   395  N N   . ARG A 1 57  ? -42.123 1.718   21.559 1.00 81.57  ? 83  ARG A N   1 
ATOM   396  C CA  . ARG A 1 57  ? -41.846 0.426   22.171 1.00 80.80  ? 83  ARG A CA  1 
ATOM   397  C C   . ARG A 1 57  ? -42.945 -0.579  21.842 1.00 83.65  ? 83  ARG A C   1 
ATOM   398  O O   . ARG A 1 57  ? -42.669 -1.771  21.672 1.00 84.41  ? 83  ARG A O   1 
ATOM   399  C CB  . ARG A 1 57  ? -41.710 0.592   23.686 1.00 84.25  ? 83  ARG A CB  1 
ATOM   400  C CG  . ARG A 1 57  ? -41.131 -0.607  24.416 1.00 87.80  ? 83  ARG A CG  1 
ATOM   401  C CD  . ARG A 1 57  ? -40.861 -0.269  25.877 1.00 90.46  ? 83  ARG A CD  1 
ATOM   402  N NE  . ARG A 1 57  ? -39.771 0.695   26.028 1.00 87.85  ? 83  ARG A NE  1 
ATOM   403  C CZ  . ARG A 1 57  ? -39.723 1.626   26.978 1.00 87.82  ? 83  ARG A CZ  1 
ATOM   404  N NH1 . ARG A 1 57  ? -40.713 1.724   27.856 1.00 80.92  ? 83  ARG A NH1 1 
ATOM   405  N NH2 . ARG A 1 57  ? -38.687 2.458   27.049 1.00 85.24  ? 83  ARG A NH2 1 
ATOM   406  N N   . GLY A 1 58  ? -44.189 -0.113  21.713 1.00 82.68  ? 84  GLY A N   1 
ATOM   407  C CA  . GLY A 1 58  ? -45.262 -1.003  21.303 1.00 77.52  ? 84  GLY A CA  1 
ATOM   408  C C   . GLY A 1 58  ? -45.198 -1.382  19.832 1.00 78.51  ? 84  GLY A C   1 
ATOM   409  O O   . GLY A 1 58  ? -45.530 -2.511  19.466 1.00 80.83  ? 84  GLY A O   1 
ATOM   410  N N   . LEU A 1 59  ? -44.760 -0.459  18.967 1.00 72.23  ? 85  LEU A N   1 
ATOM   411  C CA  . LEU A 1 59  ? -44.698 -0.778  17.544 1.00 77.33  ? 85  LEU A CA  1 
ATOM   412  C C   . LEU A 1 59  ? -43.460 -1.572  17.144 1.00 80.62  ? 85  LEU A C   1 
ATOM   413  O O   . LEU A 1 59  ? -43.441 -2.144  16.047 1.00 84.43  ? 85  LEU A O   1 
ATOM   414  C CB  . LEU A 1 59  ? -44.725 0.505   16.712 1.00 77.62  ? 85  LEU A CB  1 
ATOM   415  C CG  . LEU A 1 59  ? -45.874 1.466   16.977 1.00 79.73  ? 85  LEU A CG  1 
ATOM   416  C CD1 . LEU A 1 59  ? -45.532 2.831   16.433 1.00 80.57  ? 85  LEU A CD1 1 
ATOM   417  C CD2 . LEU A 1 59  ? -47.119 0.911   16.316 1.00 70.93  ? 85  LEU A CD2 1 
ATOM   418  N N   . GLN A 1 60  ? -42.422 -1.593  17.973 1.00 79.44  ? 86  GLN A N   1 
ATOM   419  C CA  . GLN A 1 60  ? -41.230 -2.365  17.660 1.00 77.02  ? 86  GLN A CA  1 
ATOM   420  C C   . GLN A 1 60  ? -41.444 -3.816  18.065 1.00 77.01  ? 86  GLN A C   1 
ATOM   421  O O   . GLN A 1 60  ? -42.229 -4.126  18.970 1.00 79.34  ? 86  GLN A O   1 
ATOM   422  C CB  . GLN A 1 60  ? -39.995 -1.790  18.358 1.00 76.08  ? 86  GLN A CB  1 
ATOM   423  C CG  . GLN A 1 60  ? -39.508 -0.486  17.757 1.00 78.94  ? 86  GLN A CG  1 
ATOM   424  C CD  . GLN A 1 60  ? -38.161 -0.032  18.313 1.00 81.59  ? 86  GLN A CD  1 
ATOM   425  O OE1 . GLN A 1 60  ? -37.172 0.023   17.580 1.00 85.84  ? 86  GLN A OE1 1 
ATOM   426  N NE2 . GLN A 1 60  ? -38.120 0.302   19.607 1.00 79.56  ? 86  GLN A NE2 1 
ATOM   427  N N   . MET A 1 61  ? -40.712 -4.709  17.405 1.00 77.37  ? 87  MET A N   1 
ATOM   428  C CA  . MET A 1 61  ? -40.786 -6.118  17.766 1.00 72.74  ? 87  MET A CA  1 
ATOM   429  C C   . MET A 1 61  ? -40.367 -6.313  19.217 1.00 70.89  ? 87  MET A C   1 
ATOM   430  O O   . MET A 1 61  ? -39.403 -5.707  19.698 1.00 69.15  ? 87  MET A O   1 
ATOM   431  C CB  . MET A 1 61  ? -39.888 -6.939  16.836 1.00 75.99  ? 87  MET A CB  1 
ATOM   432  C CG  . MET A 1 61  ? -40.002 -8.456  17.012 1.00 71.47  ? 87  MET A CG  1 
ATOM   433  S SD  . MET A 1 61  ? -38.938 -9.341  15.838 1.00 76.16  ? 87  MET A SD  1 
ATOM   434  C CE  . MET A 1 61  ? -39.743 -8.976  14.282 1.00 71.27  ? 87  MET A CE  1 
ATOM   435  N N   . LYS A 1 62  ? -41.121 -7.151  19.919 1.00 69.62  ? 88  LYS A N   1 
ATOM   436  C CA  . LYS A 1 62  ? -40.953 -7.370  21.344 1.00 66.83  ? 88  LYS A CA  1 
ATOM   437  C C   . LYS A 1 62  ? -41.226 -8.841  21.626 1.00 67.67  ? 88  LYS A C   1 
ATOM   438  O O   . LYS A 1 62  ? -41.834 -9.544  20.815 1.00 69.16  ? 88  LYS A O   1 
ATOM   439  C CB  . LYS A 1 62  ? -41.862 -6.448  22.177 1.00 71.47  ? 88  LYS A CB  1 
ATOM   440  C CG  . LYS A 1 62  ? -43.305 -6.334  21.667 1.00 69.75  ? 88  LYS A CG  1 
ATOM   441  C CD  . LYS A 1 62  ? -44.113 -5.412  22.561 1.00 73.30  ? 88  LYS A CD  1 
ATOM   442  C CE  . LYS A 1 62  ? -45.596 -5.492  22.238 1.00 76.28  ? 88  LYS A CE  1 
ATOM   443  N NZ  . LYS A 1 62  ? -45.891 -5.132  20.820 1.00 74.41  ? 88  LYS A NZ  1 
ATOM   444  N N   . ALA A 1 63  ? -40.753 -9.304  22.784 1.00 65.40  ? 89  ALA A N   1 
ATOM   445  C CA  . ALA A 1 63  ? -40.909 -10.709 23.146 1.00 69.84  ? 89  ALA A CA  1 
ATOM   446  C C   . ALA A 1 63  ? -42.368 -11.161 23.150 1.00 75.09  ? 89  ALA A C   1 
ATOM   447  O O   . ALA A 1 63  ? -42.657 -12.329 22.866 1.00 71.69  ? 89  ALA A O   1 
ATOM   448  C CB  . ALA A 1 63  ? -40.279 -10.958 24.517 1.00 64.52  ? 89  ALA A CB  1 
ATOM   449  N N   . GLU A 1 64  ? -43.299 -10.265 23.474 1.00 75.45  ? 90  GLU A N   1 
ATOM   450  C CA  . GLU A 1 64  ? -44.696 -10.662 23.607 1.00 77.61  ? 90  GLU A CA  1 
ATOM   451  C C   . GLU A 1 64  ? -45.362 -10.925 22.267 1.00 75.78  ? 90  GLU A C   1 
ATOM   452  O O   . GLU A 1 64  ? -46.499 -11.414 22.244 1.00 77.74  ? 90  GLU A O   1 
ATOM   453  C CB  . GLU A 1 64  ? -45.473 -9.591  24.380 1.00 75.69  ? 90  GLU A CB  1 
ATOM   454  C CG  . GLU A 1 64  ? -45.136 -9.572  25.851 1.00 78.93  ? 90  GLU A CG  1 
ATOM   455  C CD  . GLU A 1 64  ? -43.706 -9.110  26.106 1.00 91.68  ? 90  GLU A CD  1 
ATOM   456  O OE1 . GLU A 1 64  ? -43.068 -9.628  27.063 1.00 96.78  ? 90  GLU A OE1 1 
ATOM   457  O OE2 . GLU A 1 64  ? -43.214 -8.243  25.331 1.00 85.08  ? 90  GLU A OE2 1 
ATOM   458  N N   . ASP A 1 65  ? -44.680 -10.640 21.162 1.00 71.87  ? 91  ASP A N   1 
ATOM   459  C CA  . ASP A 1 65  ? -45.169 -11.033 19.851 1.00 67.79  ? 91  ASP A CA  1 
ATOM   460  C C   . ASP A 1 65  ? -45.003 -12.521 19.579 1.00 67.08  ? 91  ASP A C   1 
ATOM   461  O O   . ASP A 1 65  ? -45.426 -12.978 18.518 1.00 71.09  ? 91  ASP A O   1 
ATOM   462  C CB  . ASP A 1 65  ? -44.446 -10.236 18.770 1.00 71.88  ? 91  ASP A CB  1 
ATOM   463  C CG  . ASP A 1 65  ? -44.573 -8.738  18.966 1.00 74.30  ? 91  ASP A CG  1 
ATOM   464  O OD1 . ASP A 1 65  ? -45.435 -8.308  19.760 1.00 79.39  ? 91  ASP A OD1 1 
ATOM   465  O OD2 . ASP A 1 65  ? -43.815 -7.987  18.316 1.00 76.62  ? 91  ASP A OD2 1 
ATOM   466  N N   . TYR A 1 66  ? -44.440 -13.293 20.506 1.00 68.74  ? 92  TYR A N   1 
ATOM   467  C CA  . TYR A 1 66  ? -44.131 -14.697 20.274 1.00 70.77  ? 92  TYR A CA  1 
ATOM   468  C C   . TYR A 1 66  ? -44.778 -15.558 21.337 1.00 66.49  ? 92  TYR A C   1 
ATOM   469  O O   . TYR A 1 66  ? -44.766 -15.198 22.512 1.00 67.97  ? 92  TYR A O   1 
ATOM   470  C CB  . TYR A 1 66  ? -42.619 -14.958 20.310 1.00 64.23  ? 92  TYR A CB  1 
ATOM   471  C CG  . TYR A 1 66  ? -41.862 -14.278 19.215 1.00 67.20  ? 92  TYR A CG  1 
ATOM   472  C CD1 . TYR A 1 66  ? -41.479 -12.954 19.332 1.00 66.84  ? 92  TYR A CD1 1 
ATOM   473  C CD2 . TYR A 1 66  ? -41.529 -14.963 18.053 1.00 62.79  ? 92  TYR A CD2 1 
ATOM   474  C CE1 . TYR A 1 66  ? -40.771 -12.328 18.314 1.00 68.16  ? 92  TYR A CE1 1 
ATOM   475  C CE2 . TYR A 1 66  ? -40.829 -14.355 17.038 1.00 63.39  ? 92  TYR A CE2 1 
ATOM   476  C CZ  . TYR A 1 66  ? -40.444 -13.042 17.169 1.00 67.68  ? 92  TYR A CZ  1 
ATOM   477  O OH  . TYR A 1 66  ? -39.745 -12.440 16.146 1.00 62.55  ? 92  TYR A OH  1 
ATOM   478  N N   . ASP A 1 67  ? -45.317 -16.707 20.926 1.00 69.65  ? 93  ASP A N   1 
ATOM   479  C CA  . ASP A 1 67  ? -45.664 -17.765 21.870 1.00 74.84  ? 93  ASP A CA  1 
ATOM   480  C C   . ASP A 1 67  ? -44.409 -18.565 22.176 1.00 70.21  ? 93  ASP A C   1 
ATOM   481  O O   . ASP A 1 67  ? -43.756 -19.066 21.253 1.00 65.27  ? 93  ASP A O   1 
ATOM   482  C CB  . ASP A 1 67  ? -46.728 -18.701 21.296 1.00 75.75  ? 93  ASP A CB  1 
ATOM   483  C CG  . ASP A 1 67  ? -48.145 -18.254 21.599 1.00 85.39  ? 93  ASP A CG  1 
ATOM   484  O OD1 . ASP A 1 67  ? -48.421 -17.804 22.744 1.00 90.07  ? 93  ASP A OD1 1 
ATOM   485  O OD2 . ASP A 1 67  ? -48.994 -18.390 20.687 1.00 85.72  ? 93  ASP A OD2 1 
ATOM   486  N N   . VAL A 1 68  ? -44.069 -18.699 23.451 1.00 65.48  ? 94  VAL A N   1 
ATOM   487  C CA  . VAL A 1 68  ? -42.974 -19.584 23.831 1.00 66.40  ? 94  VAL A CA  1 
ATOM   488  C C   . VAL A 1 68  ? -43.514 -21.009 23.911 1.00 75.43  ? 94  VAL A C   1 
ATOM   489  O O   . VAL A 1 68  ? -44.352 -21.313 24.764 1.00 72.76  ? 94  VAL A O   1 
ATOM   490  C CB  . VAL A 1 68  ? -42.343 -19.152 25.159 1.00 65.37  ? 94  VAL A CB  1 
ATOM   491  C CG1 . VAL A 1 68  ? -41.480 -20.277 25.732 1.00 65.98  ? 94  VAL A CG1 1 
ATOM   492  C CG2 . VAL A 1 68  ? -41.514 -17.880 24.958 1.00 66.28  ? 94  VAL A CG2 1 
ATOM   493  N N   . VAL A 1 69  ? -43.006 -21.892 23.047 1.00 70.43  ? 95  VAL A N   1 
ATOM   494  C CA  . VAL A 1 69  ? -43.489 -23.272 22.983 1.00 66.34  ? 95  VAL A CA  1 
ATOM   495  C C   . VAL A 1 69  ? -42.707 -24.184 23.920 1.00 69.22  ? 95  VAL A C   1 
ATOM   496  O O   . VAL A 1 69  ? -43.281 -25.065 24.561 1.00 77.87  ? 95  VAL A O   1 
ATOM   497  C CB  . VAL A 1 69  ? -43.424 -23.781 21.524 1.00 71.40  ? 95  VAL A CB  1 
ATOM   498  C CG1 . VAL A 1 69  ? -43.616 -25.286 21.465 1.00 71.12  ? 95  VAL A CG1 1 
ATOM   499  C CG2 . VAL A 1 69  ? -44.451 -23.078 20.670 1.00 67.50  ? 95  VAL A CG2 1 
ATOM   500  N N   . LYS A 1 70  ? -41.396 -24.005 24.014 1.00 71.70  ? 96  LYS A N   1 
ATOM   501  C CA  . LYS A 1 70  ? -40.553 -24.881 24.817 1.00 66.79  ? 96  LYS A CA  1 
ATOM   502  C C   . LYS A 1 70  ? -39.155 -24.289 24.863 1.00 66.89  ? 96  LYS A C   1 
ATOM   503  O O   . LYS A 1 70  ? -38.715 -23.647 23.906 1.00 69.14  ? 96  LYS A O   1 
ATOM   504  C CB  . LYS A 1 70  ? -40.497 -26.304 24.249 1.00 68.28  ? 96  LYS A CB  1 
ATOM   505  C CG  . LYS A 1 70  ? -39.929 -27.283 25.240 1.00 72.79  ? 96  LYS A CG  1 
ATOM   506  C CD  . LYS A 1 70  ? -39.794 -28.665 24.656 1.00 75.26  ? 96  LYS A CD  1 
ATOM   507  C CE  . LYS A 1 70  ? -39.627 -29.678 25.794 1.00 89.34  ? 96  LYS A CE  1 
ATOM   508  N NZ  . LYS A 1 70  ? -39.848 -31.096 25.359 1.00 91.09  ? 96  LYS A NZ  1 
ATOM   509  N N   . VAL A 1 71  ? -38.467 -24.508 25.969 1.00 65.77  ? 97  VAL A N   1 
ATOM   510  C CA  . VAL A 1 71  ? -37.049 -24.192 26.056 1.00 67.51  ? 97  VAL A CA  1 
ATOM   511  C C   . VAL A 1 71  ? -36.267 -25.403 25.575 1.00 66.78  ? 97  VAL A C   1 
ATOM   512  O O   . VAL A 1 71  ? -36.474 -26.519 26.054 1.00 66.11  ? 97  VAL A O   1 
ATOM   513  C CB  . VAL A 1 71  ? -36.639 -23.804 27.486 1.00 68.56  ? 97  VAL A CB  1 
ATOM   514  C CG1 . VAL A 1 71  ? -35.110 -23.703 27.576 1.00 68.84  ? 97  VAL A CG1 1 
ATOM   515  C CG2 . VAL A 1 71  ? -37.269 -22.497 27.865 1.00 68.34  ? 97  VAL A CG2 1 
ATOM   516  N N   . ILE A 1 72  ? -35.338 -25.177 24.652 1.00 62.23  ? 98  ILE A N   1 
ATOM   517  C CA  . ILE A 1 72  ? -34.634 -26.261 23.990 1.00 65.73  ? 98  ILE A CA  1 
ATOM   518  C C   . ILE A 1 72  ? -33.131 -26.132 24.112 1.00 66.69  ? 98  ILE A C   1 
ATOM   519  O O   . ILE A 1 72  ? -32.411 -26.995 23.609 1.00 70.67  ? 98  ILE A O   1 
ATOM   520  C CB  . ILE A 1 72  ? -35.040 -26.358 22.505 1.00 65.69  ? 98  ILE A CB  1 
ATOM   521  C CG1 . ILE A 1 72  ? -34.548 -25.128 21.730 1.00 62.76  ? 98  ILE A CG1 1 
ATOM   522  C CG2 . ILE A 1 72  ? -36.553 -26.530 22.365 1.00 63.81  ? 98  ILE A CG2 1 
ATOM   523  C CD1 . ILE A 1 72  ? -35.156 -24.972 20.341 1.00 59.54  ? 98  ILE A CD1 1 
ATOM   524  N N   . GLY A 1 73  ? -32.637 -25.082 24.763 1.00 63.78  ? 99  GLY A N   1 
ATOM   525  C CA  . GLY A 1 73  ? -31.209 -24.897 24.924 1.00 62.38  ? 99  GLY A CA  1 
ATOM   526  C C   . GLY A 1 73  ? -30.924 -23.925 26.043 1.00 64.09  ? 99  GLY A C   1 
ATOM   527  O O   . GLY A 1 73  ? -31.756 -23.079 26.389 1.00 58.53  ? 99  GLY A O   1 
ATOM   528  N N   . ARG A 1 74  ? -29.726 -24.056 26.607 1.00 58.30  ? 100 ARG A N   1 
ATOM   529  C CA  . ARG A 1 74  ? -29.261 -23.196 27.682 1.00 64.07  ? 100 ARG A CA  1 
ATOM   530  C C   . ARG A 1 74  ? -27.794 -22.861 27.451 1.00 65.70  ? 100 ARG A C   1 
ATOM   531  O O   . ARG A 1 74  ? -27.059 -23.618 26.806 1.00 67.80  ? 100 ARG A O   1 
ATOM   532  C CB  . ARG A 1 74  ? -29.438 -23.849 29.072 1.00 64.46  ? 100 ARG A CB  1 
ATOM   533  N N   . GLY A 1 75  ? -27.385 -21.700 27.963 1.00 63.95  ? 101 GLY A N   1 
ATOM   534  C CA  . GLY A 1 75  ? -25.997 -21.284 27.940 1.00 63.21  ? 101 GLY A CA  1 
ATOM   535  C C   . GLY A 1 75  ? -25.699 -20.514 29.210 1.00 65.55  ? 101 GLY A C   1 
ATOM   536  O O   . GLY A 1 75  ? -26.558 -20.370 30.085 1.00 61.66  ? 101 GLY A O   1 
ATOM   537  N N   . ALA A 1 76  ? -24.471 -19.991 29.294 1.00 65.17  ? 102 ALA A N   1 
ATOM   538  C CA  . ALA A 1 76  ? -24.043 -19.284 30.507 1.00 67.18  ? 102 ALA A CA  1 
ATOM   539  C C   . ALA A 1 76  ? -24.956 -18.105 30.842 1.00 66.08  ? 102 ALA A C   1 
ATOM   540  O O   . ALA A 1 76  ? -25.249 -17.847 32.012 1.00 69.53  ? 102 ALA A O   1 
ATOM   541  C CB  . ALA A 1 76  ? -22.598 -18.808 30.351 1.00 69.34  ? 102 ALA A CB  1 
ATOM   542  N N   . PHE A 1 77  ? -25.392 -17.362 29.828 1.00 69.30  ? 103 PHE A N   1 
ATOM   543  C CA  . PHE A 1 77  ? -26.095 -16.107 30.031 1.00 68.35  ? 103 PHE A CA  1 
ATOM   544  C C   . PHE A 1 77  ? -27.552 -16.157 29.604 1.00 66.20  ? 103 PHE A C   1 
ATOM   545  O O   . PHE A 1 77  ? -28.205 -15.109 29.576 1.00 65.67  ? 103 PHE A O   1 
ATOM   546  C CB  . PHE A 1 77  ? -25.370 -14.985 29.285 1.00 66.32  ? 103 PHE A CB  1 
ATOM   547  C CG  . PHE A 1 77  ? -23.962 -14.770 29.762 1.00 69.20  ? 103 PHE A CG  1 
ATOM   548  C CD1 . PHE A 1 77  ? -23.696 -14.646 31.112 1.00 76.32  ? 103 PHE A CD1 1 
ATOM   549  C CD2 . PHE A 1 77  ? -22.908 -14.713 28.873 1.00 75.04  ? 103 PHE A CD2 1 
ATOM   550  C CE1 . PHE A 1 77  ? -22.404 -14.457 31.570 1.00 79.19  ? 103 PHE A CE1 1 
ATOM   551  C CE2 . PHE A 1 77  ? -21.611 -14.518 29.320 1.00 77.08  ? 103 PHE A CE2 1 
ATOM   552  C CZ  . PHE A 1 77  ? -21.357 -14.395 30.670 1.00 77.56  ? 103 PHE A CZ  1 
ATOM   553  N N   . GLY A 1 78  ? -28.075 -17.327 29.243 1.00 62.92  ? 104 GLY A N   1 
ATOM   554  C CA  . GLY A 1 78  ? -29.471 -17.367 28.833 1.00 60.66  ? 104 GLY A CA  1 
ATOM   555  C C   . GLY A 1 78  ? -29.881 -18.725 28.325 1.00 63.15  ? 104 GLY A C   1 
ATOM   556  O O   . GLY A 1 78  ? -29.272 -19.744 28.667 1.00 66.60  ? 104 GLY A O   1 
ATOM   557  N N   . GLU A 1 79  ? -30.895 -18.717 27.462 1.00 65.10  ? 105 GLU A N   1 
ATOM   558  C CA  . GLU A 1 79  ? -31.534 -19.940 27.004 1.00 64.24  ? 105 GLU A CA  1 
ATOM   559  C C   . GLU A 1 79  ? -31.995 -19.758 25.559 1.00 59.63  ? 105 GLU A C   1 
ATOM   560  O O   . GLU A 1 79  ? -32.080 -18.636 25.042 1.00 60.29  ? 105 GLU A O   1 
ATOM   561  C CB  . GLU A 1 79  ? -32.720 -20.303 27.905 1.00 62.36  ? 105 GLU A CB  1 
ATOM   562  C CG  . GLU A 1 79  ? -33.764 -19.204 27.979 1.00 63.92  ? 105 GLU A CG  1 
ATOM   563  C CD  . GLU A 1 79  ? -34.996 -19.597 28.793 1.00 73.97  ? 105 GLU A CD  1 
ATOM   564  O OE1 . GLU A 1 79  ? -36.121 -19.197 28.406 1.00 74.03  ? 105 GLU A OE1 1 
ATOM   565  O OE2 . GLU A 1 79  ? -34.841 -20.309 29.809 1.00 73.39  ? 105 GLU A OE2 1 
ATOM   566  N N   . VAL A 1 80  ? -32.303 -20.874 24.904 1.00 51.48  ? 106 VAL A N   1 
ATOM   567  C CA  . VAL A 1 80  ? -32.876 -20.848 23.565 1.00 59.56  ? 106 VAL A CA  1 
ATOM   568  C C   . VAL A 1 80  ? -34.297 -21.390 23.660 1.00 60.43  ? 106 VAL A C   1 
ATOM   569  O O   . VAL A 1 80  ? -34.518 -22.460 24.245 1.00 60.71  ? 106 VAL A O   1 
ATOM   570  C CB  . VAL A 1 80  ? -32.033 -21.651 22.561 1.00 61.69  ? 106 VAL A CB  1 
ATOM   571  C CG1 . VAL A 1 80  ? -32.695 -21.623 21.174 1.00 54.72  ? 106 VAL A CG1 1 
ATOM   572  C CG2 . VAL A 1 80  ? -30.580 -21.124 22.520 1.00 57.56  ? 106 VAL A CG2 1 
ATOM   573  N N   . GLN A 1 81  ? -35.257 -20.640 23.120 1.00 57.44  ? 107 GLN A N   1 
ATOM   574  C CA  . GLN A 1 81  ? -36.665 -21.028 23.139 1.00 62.72  ? 107 GLN A CA  1 
ATOM   575  C C   . GLN A 1 81  ? -37.170 -21.368 21.741 1.00 61.61  ? 107 GLN A C   1 
ATOM   576  O O   . GLN A 1 81  ? -36.850 -20.681 20.769 1.00 59.52  ? 107 GLN A O   1 
ATOM   577  C CB  . GLN A 1 81  ? -37.536 -19.905 23.716 1.00 65.44  ? 107 GLN A CB  1 
ATOM   578  C CG  . GLN A 1 81  ? -37.050 -19.368 25.049 1.00 65.57  ? 107 GLN A CG  1 
ATOM   579  C CD  . GLN A 1 81  ? -37.879 -18.198 25.565 1.00 64.30  ? 107 GLN A CD  1 
ATOM   580  O OE1 . GLN A 1 81  ? -38.393 -17.383 24.793 1.00 64.75  ? 107 GLN A OE1 1 
ATOM   581  N NE2 . GLN A 1 81  ? -37.995 -18.105 26.884 1.00 67.60  ? 107 GLN A NE2 1 
ATOM   582  N N   . LEU A 1 82  ? -37.984 -22.414 21.645 1.00 64.08  ? 108 LEU A N   1 
ATOM   583  C CA  . LEU A 1 82  ? -38.777 -22.638 20.446 1.00 60.15  ? 108 LEU A CA  1 
ATOM   584  C C   . LEU A 1 82  ? -39.989 -21.712 20.480 1.00 59.68  ? 108 LEU A C   1 
ATOM   585  O O   . LEU A 1 82  ? -40.773 -21.759 21.430 1.00 63.09  ? 108 LEU A O   1 
ATOM   586  C CB  . LEU A 1 82  ? -39.201 -24.103 20.380 1.00 63.68  ? 108 LEU A CB  1 
ATOM   587  C CG  . LEU A 1 82  ? -40.023 -24.488 19.150 1.00 63.43  ? 108 LEU A CG  1 
ATOM   588  C CD1 . LEU A 1 82  ? -39.223 -24.175 17.903 1.00 58.64  ? 108 LEU A CD1 1 
ATOM   589  C CD2 . LEU A 1 82  ? -40.373 -25.955 19.198 1.00 63.91  ? 108 LEU A CD2 1 
ATOM   590  N N   . VAL A 1 83  ? -40.155 -20.859 19.468 1.00 61.26  ? 109 VAL A N   1 
ATOM   591  C CA  . VAL A 1 83  ? -41.248 -19.895 19.507 1.00 60.92  ? 109 VAL A CA  1 
ATOM   592  C C   . VAL A 1 83  ? -42.029 -19.911 18.199 1.00 67.69  ? 109 VAL A C   1 
ATOM   593  O O   . VAL A 1 83  ? -41.544 -20.343 17.147 1.00 62.43  ? 109 VAL A O   1 
ATOM   594  C CB  . VAL A 1 83  ? -40.784 -18.446 19.785 1.00 64.64  ? 109 VAL A CB  1 
ATOM   595  C CG1 . VAL A 1 83  ? -40.103 -18.321 21.154 1.00 63.43  ? 109 VAL A CG1 1 
ATOM   596  C CG2 . VAL A 1 83  ? -39.926 -17.938 18.659 1.00 58.14  ? 109 VAL A CG2 1 
ATOM   597  N N   . ARG A 1 84  ? -43.260 -19.404 18.287 1.00 66.53  ? 110 ARG A N   1 
ATOM   598  C CA  . ARG A 1 84  ? -44.091 -19.104 17.128 1.00 67.06  ? 110 ARG A CA  1 
ATOM   599  C C   . ARG A 1 84  ? -44.450 -17.624 17.155 1.00 68.08  ? 110 ARG A C   1 
ATOM   600  O O   . ARG A 1 84  ? -45.012 -17.141 18.142 1.00 67.15  ? 110 ARG A O   1 
ATOM   601  C CB  . ARG A 1 84  ? -45.349 -19.975 17.133 1.00 69.26  ? 110 ARG A CB  1 
ATOM   602  C CG  . ARG A 1 84  ? -46.269 -19.736 15.951 1.00 72.36  ? 110 ARG A CG  1 
ATOM   603  C CD  . ARG A 1 84  ? -47.356 -20.793 15.912 1.00 70.24  ? 110 ARG A CD  1 
ATOM   604  N NE  . ARG A 1 84  ? -47.255 -21.576 14.694 1.00 72.32  ? 110 ARG A NE  1 
ATOM   605  C CZ  . ARG A 1 84  ? -47.202 -22.901 14.649 1.00 66.18  ? 110 ARG A CZ  1 
ATOM   606  N NH1 . ARG A 1 84  ? -47.252 -23.638 15.756 1.00 68.38  ? 110 ARG A NH1 1 
ATOM   607  N NH2 . ARG A 1 84  ? -47.115 -23.487 13.475 1.00 70.40  ? 110 ARG A NH2 1 
ATOM   608  N N   . HIS A 1 85  ? -44.123 -16.905 16.078 1.00 64.79  ? 111 HIS A N   1 
ATOM   609  C CA  . HIS A 1 85  ? -44.547 -15.513 15.952 1.00 72.27  ? 111 HIS A CA  1 
ATOM   610  C C   . HIS A 1 85  ? -46.064 -15.480 15.736 1.00 75.04  ? 111 HIS A C   1 
ATOM   611  O O   . HIS A 1 85  ? -46.569 -16.039 14.761 1.00 71.65  ? 111 HIS A O   1 
ATOM   612  C CB  . HIS A 1 85  ? -43.817 -14.834 14.795 1.00 67.60  ? 111 HIS A CB  1 
ATOM   613  C CG  . HIS A 1 85  ? -44.006 -13.347 14.747 1.00 76.62  ? 111 HIS A CG  1 
ATOM   614  N ND1 . HIS A 1 85  ? -44.950 -12.745 13.943 1.00 80.35  ? 111 HIS A ND1 1 
ATOM   615  C CD2 . HIS A 1 85  ? -43.366 -12.342 15.392 1.00 69.82  ? 111 HIS A CD2 1 
ATOM   616  C CE1 . HIS A 1 85  ? -44.890 -11.434 14.102 1.00 78.10  ? 111 HIS A CE1 1 
ATOM   617  N NE2 . HIS A 1 85  ? -43.935 -11.163 14.974 1.00 71.93  ? 111 HIS A NE2 1 
ATOM   618  N N   . LYS A 1 86  ? -46.795 -14.830 16.640 1.00 73.61  ? 112 LYS A N   1 
ATOM   619  C CA  . LYS A 1 86  ? -48.249 -15.000 16.665 1.00 81.18  ? 112 LYS A CA  1 
ATOM   620  C C   . LYS A 1 86  ? -48.908 -14.337 15.466 1.00 80.51  ? 112 LYS A C   1 
ATOM   621  O O   . LYS A 1 86  ? -49.825 -14.907 14.853 1.00 83.95  ? 112 LYS A O   1 
ATOM   622  C CB  . LYS A 1 86  ? -48.824 -14.459 17.965 1.00 77.86  ? 112 LYS A CB  1 
ATOM   623  C CG  . LYS A 1 86  ? -48.911 -15.579 18.950 1.00 79.33  ? 112 LYS A CG  1 
ATOM   624  C CD  . LYS A 1 86  ? -48.431 -15.176 20.310 1.00 80.37  ? 112 LYS A CD  1 
ATOM   625  C CE  . LYS A 1 86  ? -48.877 -13.785 20.667 1.00 79.00  ? 112 LYS A CE  1 
ATOM   626  N NZ  . LYS A 1 86  ? -49.024 -13.691 22.141 1.00 84.11  ? 112 LYS A NZ  1 
ATOM   627  N N   . ALA A 1 87  ? -48.400 -13.157 15.065 1.00 81.14  ? 113 ALA A N   1 
ATOM   628  C CA  . ALA A 1 87  ? -48.987 -12.473 13.921 1.00 84.46  ? 113 ALA A CA  1 
ATOM   629  C C   . ALA A 1 87  ? -48.781 -13.274 12.638 1.00 84.55  ? 113 ALA A C   1 
ATOM   630  O O   . ALA A 1 87  ? -49.699 -13.386 11.815 1.00 83.47  ? 113 ALA A O   1 
ATOM   631  C CB  . ALA A 1 87  ? -48.386 -11.089 13.810 1.00 84.22  ? 113 ALA A CB  1 
ATOM   632  N N   . SER A 1 88  ? -47.589 -13.849 12.453 1.00 81.89  ? 114 SER A N   1 
ATOM   633  C CA  . SER A 1 88  ? -47.239 -14.524 11.211 1.00 77.06  ? 114 SER A CA  1 
ATOM   634  C C   . SER A 1 88  ? -47.354 -16.037 11.296 1.00 74.85  ? 114 SER A C   1 
ATOM   635  O O   . SER A 1 88  ? -47.314 -16.700 10.256 1.00 71.90  ? 114 SER A O   1 
ATOM   636  C CB  . SER A 1 88  ? -45.798 -14.156 10.800 1.00 79.69  ? 114 SER A CB  1 
ATOM   637  O OG  . SER A 1 88  ? -44.850 -14.633 11.753 1.00 76.00  ? 114 SER A OG  1 
ATOM   638  N N   . GLN A 1 89  ? -47.471 -16.597 12.497 1.00 72.03  ? 115 GLN A N   1 
ATOM   639  C CA  . GLN A 1 89  ? -47.485 -18.043 12.734 1.00 74.37  ? 115 GLN A CA  1 
ATOM   640  C C   . GLN A 1 89  ? -46.181 -18.756 12.317 1.00 71.78  ? 115 GLN A C   1 
ATOM   641  O O   . GLN A 1 89  ? -46.119 -19.985 12.380 1.00 72.27  ? 115 GLN A O   1 
ATOM   642  C CB  . GLN A 1 89  ? -48.704 -18.705 12.069 1.00 73.33  ? 115 GLN A CB  1 
ATOM   643  C CG  . GLN A 1 89  ? -50.046 -18.294 12.710 1.00 73.76  ? 115 GLN A CG  1 
ATOM   644  C CD  . GLN A 1 89  ? -50.228 -18.835 14.112 1.00 79.15  ? 115 GLN A CD  1 
ATOM   645  O OE1 . GLN A 1 89  ? -50.210 -18.085 15.096 1.00 79.54  ? 115 GLN A OE1 1 
ATOM   646  N NE2 . GLN A 1 89  ? -50.411 -20.146 14.215 1.00 80.19  ? 115 GLN A NE2 1 
ATOM   647  N N   . LYS A 1 90  ? -45.128 -18.020 11.926 1.00 71.83  ? 116 LYS A N   1 
ATOM   648  C CA  . LYS A 1 90  ? -43.841 -18.646 11.621 1.00 74.48  ? 116 LYS A CA  1 
ATOM   649  C C   . LYS A 1 90  ? -43.105 -19.134 12.872 1.00 70.25  ? 116 LYS A C   1 
ATOM   650  O O   . LYS A 1 90  ? -43.097 -18.470 13.906 1.00 69.44  ? 116 LYS A O   1 
ATOM   651  C CB  . LYS A 1 90  ? -42.940 -17.704 10.829 1.00 74.19  ? 116 LYS A CB  1 
ATOM   652  C CG  . LYS A 1 90  ? -43.644 -17.134 9.621  1.00 79.20  ? 116 LYS A CG  1 
ATOM   653  C CD  . LYS A 1 90  ? -42.813 -17.576 8.390  1.00 87.84  ? 116 LYS A CD  1 
ATOM   654  C CE  . LYS A 1 90  ? -43.230 -17.053 6.969  1.00 93.94  ? 116 LYS A CE  1 
ATOM   655  N NZ  . LYS A 1 90  ? -42.175 -16.296 6.105  1.00 96.80  ? 116 LYS A NZ  1 
ATOM   656  N N   . VAL A 1 91  ? -42.468 -20.311 12.776 1.00 65.89  ? 117 VAL A N   1 
ATOM   657  C CA  . VAL A 1 91  ? -41.780 -20.933 13.907 1.00 68.18  ? 117 VAL A CA  1 
ATOM   658  C C   . VAL A 1 91  ? -40.306 -20.556 13.838 1.00 60.86  ? 117 VAL A C   1 
ATOM   659  O O   . VAL A 1 91  ? -39.737 -20.467 12.749 1.00 66.14  ? 117 VAL A O   1 
ATOM   660  C CB  . VAL A 1 91  ? -41.976 -22.463 13.910 1.00 65.40  ? 117 VAL A CB  1 
ATOM   661  C CG1 . VAL A 1 91  ? -41.137 -23.113 15.012 1.00 60.83  ? 117 VAL A CG1 1 
ATOM   662  C CG2 . VAL A 1 91  ? -43.440 -22.796 14.119 1.00 69.59  ? 117 VAL A CG2 1 
ATOM   663  N N   . TYR A 1 92  ? -39.704 -20.280 14.999 1.00 65.00  ? 118 TYR A N   1 
ATOM   664  C CA  . TYR A 1 92  ? -38.306 -19.880 15.099 1.00 58.65  ? 118 TYR A CA  1 
ATOM   665  C C   . TYR A 1 92  ? -37.684 -20.436 16.372 1.00 62.19  ? 118 TYR A C   1 
ATOM   666  O O   . TYR A 1 92  ? -38.373 -20.906 17.280 1.00 62.40  ? 118 TYR A O   1 
ATOM   667  C CB  . TYR A 1 92  ? -38.135 -18.354 15.119 1.00 55.62  ? 118 TYR A CB  1 
ATOM   668  C CG  . TYR A 1 92  ? -38.733 -17.554 13.967 1.00 62.66  ? 118 TYR A CG  1 
ATOM   669  C CD1 . TYR A 1 92  ? -38.008 -17.342 12.801 1.00 65.71  ? 118 TYR A CD1 1 
ATOM   670  C CD2 . TYR A 1 92  ? -39.994 -16.953 14.070 1.00 65.65  ? 118 TYR A CD2 1 
ATOM   671  C CE1 . TYR A 1 92  ? -38.514 -16.574 11.749 1.00 62.32  ? 118 TYR A CE1 1 
ATOM   672  C CE2 . TYR A 1 92  ? -40.511 -16.177 13.022 1.00 63.30  ? 118 TYR A CE2 1 
ATOM   673  C CZ  . TYR A 1 92  ? -39.770 -15.996 11.865 1.00 68.68  ? 118 TYR A CZ  1 
ATOM   674  O OH  . TYR A 1 92  ? -40.268 -15.239 10.813 1.00 73.59  ? 118 TYR A OH  1 
ATOM   675  N N   . ALA A 1 93  ? -36.352 -20.383 16.421 1.00 57.67  ? 119 ALA A N   1 
ATOM   676  C CA  . ALA A 1 93  ? -35.580 -20.560 17.646 1.00 59.49  ? 119 ALA A CA  1 
ATOM   677  C C   . ALA A 1 93  ? -35.118 -19.181 18.125 1.00 58.05  ? 119 ALA A C   1 
ATOM   678  O O   . ALA A 1 93  ? -34.562 -18.400 17.344 1.00 58.21  ? 119 ALA A O   1 
ATOM   679  C CB  . ALA A 1 93  ? -34.382 -21.489 17.406 1.00 56.55  ? 119 ALA A CB  1 
ATOM   680  N N   . MET A 1 94  ? -35.371 -18.863 19.388 1.00 60.65  ? 120 MET A N   1 
ATOM   681  C CA  . MET A 1 94  ? -35.085 -17.533 19.917 1.00 59.63  ? 120 MET A CA  1 
ATOM   682  C C   . MET A 1 94  ? -34.096 -17.656 21.069 1.00 59.28  ? 120 MET A C   1 
ATOM   683  O O   . MET A 1 94  ? -34.379 -18.342 22.053 1.00 58.63  ? 120 MET A O   1 
ATOM   684  C CB  . MET A 1 94  ? -36.373 -16.851 20.380 1.00 59.73  ? 120 MET A CB  1 
ATOM   685  C CG  . MET A 1 94  ? -36.190 -15.400 20.755 1.00 62.50  ? 120 MET A CG  1 
ATOM   686  S SD  . MET A 1 94  ? -37.746 -14.482 20.679 1.00 68.67  ? 120 MET A SD  1 
ATOM   687  C CE  . MET A 1 94  ? -38.355 -14.824 22.337 1.00 63.09  ? 120 MET A CE  1 
ATOM   688  N N   . LYS A 1 95  ? -32.928 -17.025 20.924 1.00 56.45  ? 121 LYS A N   1 
ATOM   689  C CA  . LYS A 1 95  ? -31.880 -17.018 21.939 1.00 57.89  ? 121 LYS A CA  1 
ATOM   690  C C   . LYS A 1 95  ? -31.981 -15.752 22.777 1.00 55.06  ? 121 LYS A C   1 
ATOM   691  O O   . LYS A 1 95  ? -32.098 -14.654 22.225 1.00 56.31  ? 121 LYS A O   1 
ATOM   692  C CB  . LYS A 1 95  ? -30.503 -17.108 21.283 1.00 59.46  ? 121 LYS A CB  1 
ATOM   693  C CG  . LYS A 1 95  ? -29.308 -17.019 22.251 1.00 60.90  ? 121 LYS A CG  1 
ATOM   694  C CD  . LYS A 1 95  ? -28.082 -17.596 21.538 1.00 60.84  ? 121 LYS A CD  1 
ATOM   695  C CE  . LYS A 1 95  ? -26.795 -17.427 22.313 1.00 62.07  ? 121 LYS A CE  1 
ATOM   696  N NZ  . LYS A 1 95  ? -25.676 -18.037 21.509 1.00 63.66  ? 121 LYS A NZ  1 
ATOM   697  N N   . LEU A 1 96  ? -31.934 -15.911 24.103 1.00 52.21  ? 122 LEU A N   1 
ATOM   698  C CA  . LEU A 1 96  ? -31.998 -14.817 25.069 1.00 58.61  ? 122 LEU A CA  1 
ATOM   699  C C   . LEU A 1 96  ? -30.663 -14.680 25.789 1.00 58.58  ? 122 LEU A C   1 
ATOM   700  O O   . LEU A 1 96  ? -30.097 -15.673 26.257 1.00 57.79  ? 122 LEU A O   1 
ATOM   701  C CB  . LEU A 1 96  ? -33.086 -15.065 26.125 1.00 58.77  ? 122 LEU A CB  1 
ATOM   702  C CG  . LEU A 1 96  ? -34.540 -14.741 25.762 1.00 64.96  ? 122 LEU A CG  1 
ATOM   703  C CD1 . LEU A 1 96  ? -35.031 -15.698 24.700 1.00 59.59  ? 122 LEU A CD1 1 
ATOM   704  C CD2 . LEU A 1 96  ? -35.442 -14.815 27.023 1.00 59.25  ? 122 LEU A CD2 1 
ATOM   705  N N   . LEU A 1 97  ? -30.173 -13.455 25.894 1.00 60.17  ? 123 LEU A N   1 
ATOM   706  C CA  . LEU A 1 97  ? -28.987 -13.154 26.682 1.00 62.42  ? 123 LEU A CA  1 
ATOM   707  C C   . LEU A 1 97  ? -29.361 -12.142 27.765 1.00 63.06  ? 123 LEU A C   1 
ATOM   708  O O   . LEU A 1 97  ? -29.931 -11.083 27.469 1.00 61.59  ? 123 LEU A O   1 
ATOM   709  C CB  . LEU A 1 97  ? -27.864 -12.636 25.778 1.00 55.51  ? 123 LEU A CB  1 
ATOM   710  C CG  . LEU A 1 97  ? -27.411 -13.676 24.745 1.00 61.77  ? 123 LEU A CG  1 
ATOM   711  C CD1 . LEU A 1 97  ? -26.432 -13.105 23.733 1.00 53.69  ? 123 LEU A CD1 1 
ATOM   712  C CD2 . LEU A 1 97  ? -26.825 -14.922 25.442 1.00 58.29  ? 123 LEU A CD2 1 
ATOM   713  N N   . SER A 1 98  ? -29.030 -12.458 29.014 1.00 65.77  ? 124 SER A N   1 
ATOM   714  C CA  . SER A 1 98  ? -29.398 -11.585 30.123 1.00 64.91  ? 124 SER A CA  1 
ATOM   715  C C   . SER A 1 98  ? -28.421 -10.423 30.183 1.00 66.60  ? 124 SER A C   1 
ATOM   716  O O   . SER A 1 98  ? -27.198 -10.624 30.239 1.00 59.48  ? 124 SER A O   1 
ATOM   717  C CB  . SER A 1 98  ? -29.375 -12.345 31.446 1.00 62.98  ? 124 SER A CB  1 
ATOM   718  O OG  . SER A 1 98  ? -29.354 -11.442 32.541 1.00 68.87  ? 124 SER A OG  1 
ATOM   719  N N   . LYS A 1 99  ? -28.967 -9.208  30.158 1.00 63.21  ? 125 LYS A N   1 
ATOM   720  C CA  . LYS A 1 99  ? -28.116 -8.030  30.225 1.00 69.59  ? 125 LYS A CA  1 
ATOM   721  C C   . LYS A 1 99  ? -27.464 -7.919  31.600 1.00 71.97  ? 125 LYS A C   1 
ATOM   722  O O   . LYS A 1 99  ? -26.277 -7.590  31.708 1.00 70.54  ? 125 LYS A O   1 
ATOM   723  C CB  . LYS A 1 99  ? -28.927 -6.773  29.884 1.00 66.87  ? 125 LYS A CB  1 
ATOM   724  C CG  . LYS A 1 99  ? -29.259 -6.630  28.391 1.00 68.03  ? 125 LYS A CG  1 
ATOM   725  C CD  . LYS A 1 99  ? -30.229 -5.485  28.173 1.00 65.19  ? 125 LYS A CD  1 
ATOM   726  C CE  . LYS A 1 99  ? -30.477 -5.227  26.709 1.00 64.23  ? 125 LYS A CE  1 
ATOM   727  N NZ  . LYS A 1 99  ? -31.400 -4.081  26.547 1.00 58.53  ? 125 LYS A NZ  1 
ATOM   728  N N   . PHE A 1 100 ? -28.224 -8.207  32.660 1.00 73.98  ? 126 PHE A N   1 
ATOM   729  C CA  . PHE A 1 100 ? -27.646 -8.193  33.999 1.00 80.89  ? 126 PHE A CA  1 
ATOM   730  C C   . PHE A 1 100 ? -26.462 -9.144  34.100 1.00 81.85  ? 126 PHE A C   1 
ATOM   731  O O   . PHE A 1 100 ? -25.418 -8.785  34.653 1.00 83.77  ? 126 PHE A O   1 
ATOM   732  C CB  . PHE A 1 100 ? -28.700 -8.561  35.041 1.00 82.63  ? 126 PHE A CB  1 
ATOM   733  C CG  . PHE A 1 100 ? -28.199 -8.457  36.454 1.00 92.58  ? 126 PHE A CG  1 
ATOM   734  C CD1 . PHE A 1 100 ? -28.177 -7.226  37.106 1.00 92.22  ? 126 PHE A CD1 1 
ATOM   735  C CD2 . PHE A 1 100 ? -27.725 -9.580  37.125 1.00 93.21  ? 126 PHE A CD2 1 
ATOM   736  C CE1 . PHE A 1 100 ? -27.707 -7.114  38.405 1.00 93.03  ? 126 PHE A CE1 1 
ATOM   737  C CE2 . PHE A 1 100 ? -27.246 -9.477  38.426 1.00 94.55  ? 126 PHE A CE2 1 
ATOM   738  C CZ  . PHE A 1 100 ? -27.239 -8.240  39.068 1.00 93.91  ? 126 PHE A CZ  1 
ATOM   739  N N   . GLU A 1 101 ? -26.568 -10.333 33.497 1.00 76.49  ? 127 GLU A N   1 
ATOM   740  C CA  . GLU A 1 101 ? -25.539 -11.331 33.735 1.00 73.71  ? 127 GLU A CA  1 
ATOM   741  C C   . GLU A 1 101 ? -24.337 -11.138 32.837 1.00 78.97  ? 127 GLU A C   1 
ATOM   742  O O   . GLU A 1 101 ? -23.227 -11.516 33.227 1.00 80.25  ? 127 GLU A O   1 
ATOM   743  C CB  . GLU A 1 101 ? -26.093 -12.733 33.499 1.00 75.40  ? 127 GLU A CB  1 
ATOM   744  C CG  . GLU A 1 101 ? -26.986 -13.267 34.585 1.00 80.84  ? 127 GLU A CG  1 
ATOM   745  C CD  . GLU A 1 101 ? -26.268 -13.391 35.932 1.00 89.85  ? 127 GLU A CD  1 
ATOM   746  O OE1 . GLU A 1 101 ? -25.065 -13.764 35.947 1.00 85.92  ? 127 GLU A OE1 1 
ATOM   747  O OE2 . GLU A 1 101 ? -26.920 -13.119 36.972 1.00 86.73  ? 127 GLU A OE2 1 
ATOM   748  N N   . MET A 1 102 ? -24.511 -10.471 31.691 1.00 74.11  ? 128 MET A N   1 
ATOM   749  C CA  . MET A 1 102 ? -23.366 -10.141 30.853 1.00 75.97  ? 128 MET A CA  1 
ATOM   750  C C   . MET A 1 102 ? -22.556 -8.996  31.441 1.00 80.28  ? 128 MET A C   1 
ATOM   751  O O   . MET A 1 102 ? -21.340 -8.928  31.225 1.00 78.81  ? 128 MET A O   1 
ATOM   752  C CB  . MET A 1 102 ? -23.833 -9.780  29.439 1.00 71.61  ? 128 MET A CB  1 
ATOM   753  C CG  . MET A 1 102 ? -24.315 -10.964 28.615 1.00 73.32  ? 128 MET A CG  1 
ATOM   754  S SD  . MET A 1 102 ? -24.858 -10.508 26.944 1.00 65.01  ? 128 MET A SD  1 
ATOM   755  C CE  . MET A 1 102 ? -26.250 -9.446  27.341 1.00 65.95  ? 128 MET A CE  1 
ATOM   756  N N   . ILE A 1 103 ? -23.189 -8.116  32.213 1.00 79.82  ? 129 ILE A N   1 
ATOM   757  C CA  . ILE A 1 103 ? -22.448 -6.995  32.780 1.00 84.02  ? 129 ILE A CA  1 
ATOM   758  C C   . ILE A 1 103 ? -21.913 -7.341  34.160 1.00 81.63  ? 129 ILE A C   1 
ATOM   759  O O   . ILE A 1 103 ? -20.776 -7.001  34.484 1.00 85.36  ? 129 ILE A O   1 
ATOM   760  C CB  . ILE A 1 103 ? -23.325 -5.728  32.815 1.00 82.23  ? 129 ILE A CB  1 
ATOM   761  C CG1 . ILE A 1 103 ? -23.495 -5.168  31.407 1.00 79.25  ? 129 ILE A CG1 1 
ATOM   762  C CG2 . ILE A 1 103 ? -22.689 -4.662  33.699 1.00 78.87  ? 129 ILE A CG2 1 
ATOM   763  C CD1 . ILE A 1 103 ? -24.399 -3.968  31.350 1.00 76.85  ? 129 ILE A CD1 1 
ATOM   764  N N   . LYS A 1 104 ? -22.683 -8.099  34.947 1.00 80.98  ? 130 LYS A N   1 
ATOM   765  C CA  . LYS A 1 104 ? -22.201 -8.575  36.238 1.00 80.38  ? 130 LYS A CA  1 
ATOM   766  C C   . LYS A 1 104 ? -21.032 -9.536  36.096 1.00 83.44  ? 130 LYS A C   1 
ATOM   767  O O   . LYS A 1 104 ? -20.324 -9.777  37.079 1.00 89.34  ? 130 LYS A O   1 
ATOM   768  C CB  . LYS A 1 104 ? -23.330 -9.255  37.019 1.00 78.22  ? 130 LYS A CB  1 
ATOM   769  N N   . ARG A 1 105 ? -20.786 -10.063 34.891 1.00 82.39  ? 131 ARG A N   1 
ATOM   770  C CA  . ARG A 1 105 ? -19.668 -10.969 34.652 1.00 83.40  ? 131 ARG A CA  1 
ATOM   771  C C   . ARG A 1 105 ? -18.750 -10.425 33.565 1.00 89.32  ? 131 ARG A C   1 
ATOM   772  O O   . ARG A 1 105 ? -17.969 -11.176 32.973 1.00 91.06  ? 131 ARG A O   1 
ATOM   773  C CB  . ARG A 1 105 ? -20.181 -12.377 34.327 1.00 75.95  ? 131 ARG A CB  1 
ATOM   774  C CG  . ARG A 1 105 ? -20.929 -13.011 35.526 1.00 78.92  ? 131 ARG A CG  1 
ATOM   775  C CD  . ARG A 1 105 ? -21.077 -14.530 35.450 1.00 85.90  ? 131 ARG A CD  1 
ATOM   776  N NE  . ARG A 1 105 ? -22.483 -14.958 35.505 1.00 88.23  ? 131 ARG A NE  1 
ATOM   777  C CZ  . ARG A 1 105 ? -22.981 -16.029 34.874 1.00 90.86  ? 131 ARG A CZ  1 
ATOM   778  N NH1 . ARG A 1 105 ? -22.203 -16.803 34.116 1.00 83.71  ? 131 ARG A NH1 1 
ATOM   779  N NH2 . ARG A 1 105 ? -24.274 -16.321 34.984 1.00 91.08  ? 131 ARG A NH2 1 
ATOM   780  N N   . SER A 1 106 ? -18.857 -9.117  33.306 1.00 90.26  ? 132 SER A N   1 
ATOM   781  C CA  . SER A 1 106 ? -17.852 -8.311  32.607 1.00 90.36  ? 132 SER A CA  1 
ATOM   782  C C   . SER A 1 106 ? -17.433 -8.878  31.249 1.00 93.34  ? 132 SER A C   1 
ATOM   783  O O   . SER A 1 106 ? -16.287 -8.730  30.819 1.00 97.88  ? 132 SER A O   1 
ATOM   784  C CB  . SER A 1 106 ? -16.629 -8.098  33.502 1.00 91.14  ? 132 SER A CB  1 
ATOM   785  O OG  . SER A 1 106 ? -16.853 -7.048  34.428 1.00 89.04  ? 132 SER A OG  1 
ATOM   786  N N   . ASP A 1 107 ? -18.350 -9.548  30.565 1.00 88.99  ? 133 ASP A N   1 
ATOM   787  C CA  . ASP A 1 107 ? -18.215 -9.739  29.124 1.00 94.79  ? 133 ASP A CA  1 
ATOM   788  C C   . ASP A 1 107 ? -19.543 -9.350  28.483 1.00 90.39  ? 133 ASP A C   1 
ATOM   789  O O   . ASP A 1 107 ? -20.566 -10.011 28.706 1.00 87.57  ? 133 ASP A O   1 
ATOM   790  C CB  . ASP A 1 107 ? -17.773 -11.156 28.743 1.00 96.20  ? 133 ASP A CB  1 
ATOM   791  C CG  . ASP A 1 107 ? -18.620 -12.224 29.366 1.00 94.60  ? 133 ASP A CG  1 
ATOM   792  O OD1 . ASP A 1 107 ? -19.079 -12.029 30.519 1.00 92.72  ? 133 ASP A OD1 1 
ATOM   793  O OD2 . ASP A 1 107 ? -18.791 -13.271 28.701 1.00 90.31  ? 133 ASP A OD2 1 
ATOM   794  N N   . SER A 1 108 ? -19.529 -8.255  27.723 1.00 86.86  ? 134 SER A N   1 
ATOM   795  C CA  . SER A 1 108 ? -20.720 -7.683  27.113 1.00 80.87  ? 134 SER A CA  1 
ATOM   796  C C   . SER A 1 108 ? -20.455 -7.359  25.652 1.00 81.46  ? 134 SER A C   1 
ATOM   797  O O   . SER A 1 108 ? -21.049 -6.424  25.108 1.00 80.16  ? 134 SER A O   1 
ATOM   798  C CB  . SER A 1 108 ? -21.191 -6.429  27.850 1.00 79.46  ? 134 SER A CB  1 
ATOM   799  O OG  . SER A 1 108 ? -21.209 -6.624  29.248 1.00 86.32  ? 134 SER A OG  1 
ATOM   800  N N   . ALA A 1 109 ? -19.536 -8.105  25.009 1.00 77.02  ? 135 ALA A N   1 
ATOM   801  C CA  . ALA A 1 109 ? -19.177 -7.838  23.628 1.00 69.31  ? 135 ALA A CA  1 
ATOM   802  C C   . ALA A 1 109 ? -19.151 -9.056  22.713 1.00 71.02  ? 135 ALA A C   1 
ATOM   803  O O   . ALA A 1 109 ? -18.956 -8.883  21.505 1.00 72.47  ? 135 ALA A O   1 
ATOM   804  C CB  . ALA A 1 109 ? -17.803 -7.163  23.566 1.00 79.12  ? 135 ALA A CB  1 
ATOM   805  N N   . PHE A 1 110 ? -19.391 -10.268 23.225 1.00 70.11  ? 136 PHE A N   1 
ATOM   806  C CA  . PHE A 1 110 ? -19.282 -11.456 22.375 1.00 67.39  ? 136 PHE A CA  1 
ATOM   807  C C   . PHE A 1 110 ? -20.419 -11.534 21.367 1.00 69.95  ? 136 PHE A C   1 
ATOM   808  O O   . PHE A 1 110 ? -20.275 -12.159 20.304 1.00 68.34  ? 136 PHE A O   1 
ATOM   809  C CB  . PHE A 1 110 ? -19.273 -12.719 23.226 1.00 73.71  ? 136 PHE A CB  1 
ATOM   810  C CG  . PHE A 1 110 ? -20.508 -12.891 24.054 1.00 71.29  ? 136 PHE A CG  1 
ATOM   811  C CD1 . PHE A 1 110 ? -20.575 -12.354 25.328 1.00 69.59  ? 136 PHE A CD1 1 
ATOM   812  C CD2 . PHE A 1 110 ? -21.602 -13.586 23.556 1.00 65.14  ? 136 PHE A CD2 1 
ATOM   813  C CE1 . PHE A 1 110 ? -21.708 -12.494 26.093 1.00 68.15  ? 136 PHE A CE1 1 
ATOM   814  C CE2 . PHE A 1 110 ? -22.745 -13.739 24.319 1.00 61.47  ? 136 PHE A CE2 1 
ATOM   815  C CZ  . PHE A 1 110 ? -22.800 -13.189 25.588 1.00 66.63  ? 136 PHE A CZ  1 
ATOM   816  N N   . PHE A 1 111 ? -21.562 -10.939 21.690 1.00 62.16  ? 137 PHE A N   1 
ATOM   817  C CA  . PHE A 1 111 ? -22.738 -11.186 20.882 1.00 65.58  ? 137 PHE A CA  1 
ATOM   818  C C   . PHE A 1 111 ? -22.689 -10.436 19.567 1.00 59.97  ? 137 PHE A C   1 
ATOM   819  O O   . PHE A 1 111 ? -23.481 -10.748 18.682 1.00 61.22  ? 137 PHE A O   1 
ATOM   820  C CB  . PHE A 1 111 ? -23.998 -10.792 21.664 1.00 63.79  ? 137 PHE A CB  1 
ATOM   821  C CG  . PHE A 1 111 ? -23.892 -9.450  22.322 1.00 62.90  ? 137 PHE A CG  1 
ATOM   822  C CD1 . PHE A 1 111 ? -23.958 -8.282  21.561 1.00 58.71  ? 137 PHE A CD1 1 
ATOM   823  C CD2 . PHE A 1 111 ? -23.695 -9.352  23.697 1.00 61.78  ? 137 PHE A CD2 1 
ATOM   824  C CE1 . PHE A 1 111 ? -23.832 -7.041  22.164 1.00 64.32  ? 137 PHE A CE1 1 
ATOM   825  C CE2 . PHE A 1 111 ? -23.567 -8.113  24.308 1.00 64.41  ? 137 PHE A CE2 1 
ATOM   826  C CZ  . PHE A 1 111 ? -23.633 -6.957  23.545 1.00 62.90  ? 137 PHE A CZ  1 
ATOM   827  N N   . TRP A 1 112 ? -21.792 -9.451  19.429 1.00 63.64  ? 138 TRP A N   1 
ATOM   828  C CA  . TRP A 1 112 ? -21.747 -8.657  18.206 1.00 62.49  ? 138 TRP A CA  1 
ATOM   829  C C   . TRP A 1 112 ? -21.352 -9.519  17.027 1.00 68.51  ? 138 TRP A C   1 
ATOM   830  O O   . TRP A 1 112 ? -21.932 -9.402  15.938 1.00 59.95  ? 138 TRP A O   1 
ATOM   831  C CB  . TRP A 1 112 ? -20.764 -7.489  18.343 1.00 62.61  ? 138 TRP A CB  1 
ATOM   832  C CG  . TRP A 1 112 ? -21.273 -6.425  19.236 1.00 65.98  ? 138 TRP A CG  1 
ATOM   833  C CD1 . TRP A 1 112 ? -20.750 -6.052  20.432 1.00 65.77  ? 138 TRP A CD1 1 
ATOM   834  C CD2 . TRP A 1 112 ? -22.440 -5.617  19.036 1.00 66.22  ? 138 TRP A CD2 1 
ATOM   835  N NE1 . TRP A 1 112 ? -21.503 -5.055  20.988 1.00 64.46  ? 138 TRP A NE1 1 
ATOM   836  C CE2 . TRP A 1 112 ? -22.550 -4.766  20.154 1.00 71.04  ? 138 TRP A CE2 1 
ATOM   837  C CE3 . TRP A 1 112 ? -23.400 -5.530  18.027 1.00 59.93  ? 138 TRP A CE3 1 
ATOM   838  C CZ2 . TRP A 1 112 ? -23.587 -3.832  20.291 1.00 69.61  ? 138 TRP A CZ2 1 
ATOM   839  C CZ3 . TRP A 1 112 ? -24.428 -4.595  18.161 1.00 64.65  ? 138 TRP A CZ3 1 
ATOM   840  C CH2 . TRP A 1 112 ? -24.517 -3.770  19.287 1.00 63.10  ? 138 TRP A CH2 1 
ATOM   841  N N   . GLU A 1 113 ? -20.404 -10.436 17.246 1.00 64.73  ? 139 GLU A N   1 
ATOM   842  C CA  . GLU A 1 113 ? -19.931 -11.278 16.157 1.00 66.42  ? 139 GLU A CA  1 
ATOM   843  C C   . GLU A 1 113 ? -20.929 -12.377 15.853 1.00 61.20  ? 139 GLU A C   1 
ATOM   844  O O   . GLU A 1 113 ? -21.161 -12.699 14.684 1.00 58.70  ? 139 GLU A O   1 
ATOM   845  C CB  . GLU A 1 113 ? -18.578 -11.894 16.511 1.00 65.10  ? 139 GLU A CB  1 
ATOM   846  C CG  . GLU A 1 113 ? -17.714 -12.141 15.310 1.00 73.73  ? 139 GLU A CG  1 
ATOM   847  C CD  . GLU A 1 113 ? -17.393 -10.860 14.562 1.00 83.60  ? 139 GLU A CD  1 
ATOM   848  O OE1 . GLU A 1 113 ? -17.198 -9.821  15.230 1.00 90.18  ? 139 GLU A OE1 1 
ATOM   849  O OE2 . GLU A 1 113 ? -17.329 -10.889 13.312 1.00 84.70  ? 139 GLU A OE2 1 
ATOM   850  N N   . GLU A 1 114 ? -21.540 -12.937 16.898 1.00 63.66  ? 140 GLU A N   1 
ATOM   851  C CA  . GLU A 1 114 ? -22.608 -13.910 16.713 1.00 63.32  ? 140 GLU A CA  1 
ATOM   852  C C   . GLU A 1 114 ? -23.739 -13.322 15.871 1.00 60.33  ? 140 GLU A C   1 
ATOM   853  O O   . GLU A 1 114 ? -24.209 -13.946 14.914 1.00 58.07  ? 140 GLU A O   1 
ATOM   854  C CB  . GLU A 1 114 ? -23.112 -14.386 18.075 1.00 59.38  ? 140 GLU A CB  1 
ATOM   855  C CG  . GLU A 1 114 ? -23.792 -15.737 18.054 1.00 66.59  ? 140 GLU A CG  1 
ATOM   856  C CD  . GLU A 1 114 ? -24.402 -16.097 19.397 1.00 73.73  ? 140 GLU A CD  1 
ATOM   857  O OE1 . GLU A 1 114 ? -23.998 -15.483 20.414 1.00 78.68  ? 140 GLU A OE1 1 
ATOM   858  O OE2 . GLU A 1 114 ? -25.285 -16.991 19.448 1.00 75.08  ? 140 GLU A OE2 1 
ATOM   859  N N   . ARG A 1 115 ? -24.202 -12.126 16.222 1.00 61.30  ? 141 ARG A N   1 
ATOM   860  C CA  . ARG A 1 115 ? -25.288 -11.520 15.458 1.00 62.11  ? 141 ARG A CA  1 
ATOM   861  C C   . ARG A 1 115 ? -24.896 -11.326 13.998 1.00 61.49  ? 141 ARG A C   1 
ATOM   862  O O   . ARG A 1 115 ? -25.675 -11.656 13.092 1.00 61.41  ? 141 ARG A O   1 
ATOM   863  C CB  . ARG A 1 115 ? -25.706 -10.204 16.117 1.00 58.73  ? 141 ARG A CB  1 
ATOM   864  C CG  . ARG A 1 115 ? -26.430 -9.174  15.242 1.00 62.21  ? 141 ARG A CG  1 
ATOM   865  C CD  . ARG A 1 115 ? -26.437 -7.923  16.077 1.00 63.55  ? 141 ARG A CD  1 
ATOM   866  N NE  . ARG A 1 115 ? -27.110 -6.773  15.519 1.00 66.54  ? 141 ARG A NE  1 
ATOM   867  C CZ  . ARG A 1 115 ? -26.541 -5.900  14.698 1.00 67.14  ? 141 ARG A CZ  1 
ATOM   868  N NH1 . ARG A 1 115 ? -27.237 -4.854  14.263 1.00 65.27  ? 141 ARG A NH1 1 
ATOM   869  N NH2 . ARG A 1 115 ? -25.288 -6.071  14.312 1.00 67.97  ? 141 ARG A NH2 1 
ATOM   870  N N   . ASP A 1 116 ? -23.674 -10.835 13.745 1.00 58.71  ? 142 ASP A N   1 
ATOM   871  C CA  . ASP A 1 116 ? -23.284 -10.479 12.381 1.00 56.19  ? 142 ASP A CA  1 
ATOM   872  C C   . ASP A 1 116 ? -23.078 -11.711 11.511 1.00 56.56  ? 142 ASP A C   1 
ATOM   873  O O   . ASP A 1 116 ? -23.440 -11.715 10.329 1.00 54.83  ? 142 ASP A O   1 
ATOM   874  C CB  . ASP A 1 116 ? -22.004 -9.632  12.413 1.00 65.44  ? 142 ASP A CB  1 
ATOM   875  C CG  . ASP A 1 116 ? -22.291 -8.152  12.641 1.00 70.22  ? 142 ASP A CG  1 
ATOM   876  O OD1 . ASP A 1 116 ? -23.359 -7.852  13.210 1.00 69.02  ? 142 ASP A OD1 1 
ATOM   877  O OD2 . ASP A 1 116 ? -21.456 -7.290  12.273 1.00 78.24  ? 142 ASP A OD2 1 
ATOM   878  N N   . ILE A 1 117 ? -22.533 -12.779 12.079 1.00 54.83  ? 143 ILE A N   1 
ATOM   879  C CA  . ILE A 1 117 ? -22.344 -14.001 11.309 1.00 55.41  ? 143 ILE A CA  1 
ATOM   880  C C   . ILE A 1 117 ? -23.693 -14.572 10.887 1.00 55.43  ? 143 ILE A C   1 
ATOM   881  O O   . ILE A 1 117 ? -23.914 -14.908 9.719  1.00 59.71  ? 143 ILE A O   1 
ATOM   882  C CB  . ILE A 1 117 ? -21.518 -15.014 12.125 1.00 54.98  ? 143 ILE A CB  1 
ATOM   883  C CG1 . ILE A 1 117 ? -20.089 -14.487 12.326 1.00 61.47  ? 143 ILE A CG1 1 
ATOM   884  C CG2 . ILE A 1 117 ? -21.460 -16.350 11.414 1.00 59.07  ? 143 ILE A CG2 1 
ATOM   885  C CD1 . ILE A 1 117 ? -19.294 -15.264 13.397 1.00 61.29  ? 143 ILE A CD1 1 
ATOM   886  N N   . MET A 1 118 ? -24.596 -14.751 11.844 1.00 55.74  ? 144 MET A N   1 
ATOM   887  C CA  . MET A 1 118 ? -25.873 -15.358 11.508 1.00 56.71  ? 144 MET A CA  1 
ATOM   888  C C   . MET A 1 118 ? -26.710 -14.438 10.625 1.00 56.24  ? 144 MET A C   1 
ATOM   889  O O   . MET A 1 118 ? -27.504 -14.920 9.818  1.00 59.72  ? 144 MET A O   1 
ATOM   890  C CB  . MET A 1 118 ? -26.616 -15.733 12.780 1.00 54.14  ? 144 MET A CB  1 
ATOM   891  C CG  . MET A 1 118 ? -25.933 -16.874 13.543 1.00 56.48  ? 144 MET A CG  1 
ATOM   892  S SD  . MET A 1 118 ? -26.970 -17.459 14.888 1.00 57.25  ? 144 MET A SD  1 
ATOM   893  C CE  . MET A 1 118 ? -27.011 -15.973 15.874 1.00 59.00  ? 144 MET A CE  1 
ATOM   894  N N   . ALA A 1 119 ? -26.529 -13.120 10.745 1.00 59.78  ? 145 ALA A N   1 
ATOM   895  C CA  . ALA A 1 119 ? -27.318 -12.196 9.938  1.00 59.49  ? 145 ALA A CA  1 
ATOM   896  C C   . ALA A 1 119 ? -26.836 -12.169 8.497  1.00 62.75  ? 145 ALA A C   1 
ATOM   897  O O   . ALA A 1 119 ? -27.652 -12.153 7.566  1.00 56.90  ? 145 ALA A O   1 
ATOM   898  C CB  . ALA A 1 119 ? -27.267 -10.788 10.542 1.00 61.04  ? 145 ALA A CB  1 
ATOM   899  N N   . PHE A 1 120 ? -25.513 -12.188 8.297  1.00 59.94  ? 146 PHE A N   1 
ATOM   900  C CA  . PHE A 1 120 ? -24.910 -11.830 7.028  1.00 57.68  ? 146 PHE A CA  1 
ATOM   901  C C   . PHE A 1 120 ? -24.067 -12.924 6.387  1.00 59.58  ? 146 PHE A C   1 
ATOM   902  O O   . PHE A 1 120 ? -23.628 -12.734 5.254  1.00 65.90  ? 146 PHE A O   1 
ATOM   903  C CB  . PHE A 1 120 ? -24.034 -10.575 7.186  1.00 61.43  ? 146 PHE A CB  1 
ATOM   904  C CG  . PHE A 1 120 ? -24.754 -9.406  7.797  1.00 62.12  ? 146 PHE A CG  1 
ATOM   905  C CD1 . PHE A 1 120 ? -25.964 -8.971  7.275  1.00 63.37  ? 146 PHE A CD1 1 
ATOM   906  C CD2 . PHE A 1 120 ? -24.211 -8.731  8.883  1.00 62.61  ? 146 PHE A CD2 1 
ATOM   907  C CE1 . PHE A 1 120 ? -26.640 -7.894  7.835  1.00 65.13  ? 146 PHE A CE1 1 
ATOM   908  C CE2 . PHE A 1 120 ? -24.873 -7.650  9.455  1.00 63.28  ? 146 PHE A CE2 1 
ATOM   909  C CZ  . PHE A 1 120 ? -26.096 -7.231  8.928  1.00 72.40  ? 146 PHE A CZ  1 
ATOM   910  N N   . ALA A 1 121 ? -23.807 -14.049 7.058  1.00 62.18  ? 147 ALA A N   1 
ATOM   911  C CA  . ALA A 1 121 ? -23.010 -15.094 6.408  1.00 60.95  ? 147 ALA A CA  1 
ATOM   912  C C   . ALA A 1 121 ? -23.673 -15.579 5.124  1.00 63.29  ? 147 ALA A C   1 
ATOM   913  O O   . ALA A 1 121 ? -22.988 -15.885 4.138  1.00 63.51  ? 147 ALA A O   1 
ATOM   914  C CB  . ALA A 1 121 ? -22.776 -16.277 7.349  1.00 57.70  ? 147 ALA A CB  1 
ATOM   915  N N   . ASN A 1 122 ? -24.999 -15.685 5.117  1.00 61.29  ? 148 ASN A N   1 
ATOM   916  C CA  . ASN A 1 122 ? -25.709 -16.160 3.936  1.00 63.23  ? 148 ASN A CA  1 
ATOM   917  C C   . ASN A 1 122 ? -25.069 -17.456 3.447  1.00 59.54  ? 148 ASN A C   1 
ATOM   918  O O   . ASN A 1 122 ? -24.638 -17.595 2.303  1.00 61.74  ? 148 ASN A O   1 
ATOM   919  C CB  . ASN A 1 122 ? -25.716 -15.077 2.845  1.00 65.17  ? 148 ASN A CB  1 
ATOM   920  C CG  . ASN A 1 122 ? -26.571 -15.450 1.641  1.00 74.74  ? 148 ASN A CG  1 
ATOM   921  O OD1 . ASN A 1 122 ? -27.578 -16.154 1.770  1.00 78.02  ? 148 ASN A OD1 1 
ATOM   922  N ND2 . ASN A 1 122 ? -26.168 -14.988 0.465  1.00 71.92  ? 148 ASN A ND2 1 
ATOM   923  N N   . SER A 1 123 ? -25.018 -18.422 4.346  1.00 58.61  ? 149 SER A N   1 
ATOM   924  C CA  . SER A 1 123 ? -24.346 -19.649 3.988  1.00 56.20  ? 149 SER A CA  1 
ATOM   925  C C   . SER A 1 123 ? -25.228 -20.809 4.406  1.00 47.53  ? 149 SER A C   1 
ATOM   926  O O   . SER A 1 123 ? -25.890 -20.732 5.433  1.00 55.27  ? 149 SER A O   1 
ATOM   927  C CB  . SER A 1 123 ? -22.980 -19.764 4.702  1.00 51.40  ? 149 SER A CB  1 
ATOM   928  O OG  . SER A 1 123 ? -22.567 -21.130 4.768  1.00 53.54  ? 149 SER A OG  1 
ATOM   929  N N   . PRO A 1 124 ? -25.255 -21.900 3.644  1.00 51.65  ? 150 PRO A N   1 
ATOM   930  C CA  . PRO A 1 124 ? -26.082 -23.033 4.068  1.00 50.66  ? 150 PRO A CA  1 
ATOM   931  C C   . PRO A 1 124 ? -25.525 -23.723 5.286  1.00 54.77  ? 150 PRO A C   1 
ATOM   932  O O   . PRO A 1 124 ? -26.239 -24.552 5.876  1.00 52.30  ? 150 PRO A O   1 
ATOM   933  C CB  . PRO A 1 124 ? -26.086 -23.964 2.847  1.00 49.74  ? 150 PRO A CB  1 
ATOM   934  C CG  . PRO A 1 124 ? -24.803 -23.662 2.170  1.00 52.34  ? 150 PRO A CG  1 
ATOM   935  C CD  . PRO A 1 124 ? -24.557 -22.167 2.376  1.00 48.03  ? 150 PRO A CD  1 
ATOM   936  N N   . TRP A 1 125 ? -24.292 -23.371 5.710  1.00 52.68  ? 151 TRP A N   1 
ATOM   937  C CA  . TRP A 1 125 ? -23.609 -23.999 6.839  1.00 45.48  ? 151 TRP A CA  1 
ATOM   938  C C   . TRP A 1 125 ? -23.787 -23.245 8.142  1.00 45.53  ? 151 TRP A C   1 
ATOM   939  O O   . TRP A 1 125 ? -23.364 -23.738 9.199  1.00 49.04  ? 151 TRP A O   1 
ATOM   940  C CB  . TRP A 1 125 ? -22.093 -24.114 6.539  1.00 53.32  ? 151 TRP A CB  1 
ATOM   941  C CG  . TRP A 1 125 ? -21.773 -24.983 5.373  1.00 47.50  ? 151 TRP A CG  1 
ATOM   942  C CD1 . TRP A 1 125 ? -21.173 -24.607 4.184  1.00 50.93  ? 151 TRP A CD1 1 
ATOM   943  C CD2 . TRP A 1 125 ? -22.057 -26.382 5.257  1.00 49.90  ? 151 TRP A CD2 1 
ATOM   944  N NE1 . TRP A 1 125 ? -21.069 -25.704 3.342  1.00 46.28  ? 151 TRP A NE1 1 
ATOM   945  C CE2 . TRP A 1 125 ? -21.578 -26.807 3.992  1.00 49.47  ? 151 TRP A CE2 1 
ATOM   946  C CE3 . TRP A 1 125 ? -22.645 -27.326 6.116  1.00 50.71  ? 151 TRP A CE3 1 
ATOM   947  C CZ2 . TRP A 1 125 ? -21.693 -28.127 3.560  1.00 50.19  ? 151 TRP A CZ2 1 
ATOM   948  C CZ3 . TRP A 1 125 ? -22.759 -28.623 5.688  1.00 50.98  ? 151 TRP A CZ3 1 
ATOM   949  C CH2 . TRP A 1 125 ? -22.289 -29.018 4.406  1.00 48.81  ? 151 TRP A CH2 1 
ATOM   950  N N   . VAL A 1 126 ? -24.411 -22.073 8.093  1.00 52.09  ? 152 VAL A N   1 
ATOM   951  C CA  . VAL A 1 126 ? -24.558 -21.178 9.229  1.00 49.57  ? 152 VAL A CA  1 
ATOM   952  C C   . VAL A 1 126 ? -26.048 -20.927 9.448  1.00 54.61  ? 152 VAL A C   1 
ATOM   953  O O   . VAL A 1 126 ? -26.752 -20.519 8.515  1.00 53.89  ? 152 VAL A O   1 
ATOM   954  C CB  . VAL A 1 126 ? -23.825 -19.848 8.966  1.00 53.98  ? 152 VAL A CB  1 
ATOM   955  C CG1 . VAL A 1 126 ? -24.084 -18.872 10.093 1.00 56.68  ? 152 VAL A CG1 1 
ATOM   956  C CG2 . VAL A 1 126 ? -22.314 -20.089 8.761  1.00 54.16  ? 152 VAL A CG2 1 
ATOM   957  N N   . VAL A 1 127 ? -26.512 -21.141 10.680 1.00 54.98  ? 153 VAL A N   1 
ATOM   958  C CA  . VAL A 1 127 ? -27.880 -20.792 11.068 1.00 55.51  ? 153 VAL A CA  1 
ATOM   959  C C   . VAL A 1 127 ? -28.143 -19.324 10.767 1.00 55.32  ? 153 VAL A C   1 
ATOM   960  O O   . VAL A 1 127 ? -27.378 -18.439 11.168 1.00 56.73  ? 153 VAL A O   1 
ATOM   961  C CB  . VAL A 1 127 ? -28.085 -21.096 12.561 1.00 55.02  ? 153 VAL A CB  1 
ATOM   962  C CG1 . VAL A 1 127 ? -29.445 -20.580 13.057 1.00 54.85  ? 153 VAL A CG1 1 
ATOM   963  C CG2 . VAL A 1 127 ? -27.915 -22.593 12.825 1.00 53.68  ? 153 VAL A CG2 1 
ATOM   964  N N   . GLN A 1 128 ? -29.230 -19.053 10.056 1.00 56.85  ? 154 GLN A N   1 
ATOM   965  C CA  . GLN A 1 128 ? -29.556 -17.683 9.686  1.00 60.17  ? 154 GLN A CA  1 
ATOM   966  C C   . GLN A 1 128 ? -30.299 -16.976 10.818 1.00 59.34  ? 154 GLN A C   1 
ATOM   967  O O   . GLN A 1 128 ? -31.132 -17.578 11.508 1.00 57.06  ? 154 GLN A O   1 
ATOM   968  C CB  . GLN A 1 128 ? -30.408 -17.679 8.414  1.00 64.46  ? 154 GLN A CB  1 
ATOM   969  C CG  . GLN A 1 128 ? -30.680 -16.313 7.775  1.00 65.80  ? 154 GLN A CG  1 
ATOM   970  C CD  . GLN A 1 128 ? -31.523 -16.447 6.495  1.00 76.25  ? 154 GLN A CD  1 
ATOM   971  O OE1 . GLN A 1 128 ? -32.040 -17.534 6.192  1.00 71.73  ? 154 GLN A OE1 1 
ATOM   972  N NE2 . GLN A 1 128 ? -31.677 -15.342 5.752  1.00 76.55  ? 154 GLN A NE2 1 
ATOM   973  N N   . LEU A 1 129 ? -29.967 -15.700 11.026 1.00 57.65  ? 155 LEU A N   1 
ATOM   974  C CA  . LEU A 1 129 ? -30.701 -14.826 11.932 1.00 58.23  ? 155 LEU A CA  1 
ATOM   975  C C   . LEU A 1 129 ? -31.646 -13.949 11.113 1.00 63.34  ? 155 LEU A C   1 
ATOM   976  O O   . LEU A 1 129 ? -31.267 -13.401 10.078 1.00 58.46  ? 155 LEU A O   1 
ATOM   977  C CB  . LEU A 1 129 ? -29.763 -13.943 12.761 1.00 59.48  ? 155 LEU A CB  1 
ATOM   978  C CG  . LEU A 1 129 ? -30.350 -12.929 13.751 1.00 62.97  ? 155 LEU A CG  1 
ATOM   979  C CD1 . LEU A 1 129 ? -29.580 -12.939 15.053 1.00 64.42  ? 155 LEU A CD1 1 
ATOM   980  C CD2 . LEU A 1 129 ? -30.314 -11.536 13.171 1.00 64.15  ? 155 LEU A CD2 1 
ATOM   981  N N   . PHE A 1 130 ? -32.877 -13.821 11.581 1.00 64.02  ? 156 PHE A N   1 
ATOM   982  C CA  . PHE A 1 130 ? -33.865 -12.975 10.932 1.00 65.19  ? 156 PHE A CA  1 
ATOM   983  C C   . PHE A 1 130 ? -34.100 -11.671 11.669 1.00 63.51  ? 156 PHE A C   1 
ATOM   984  O O   . PHE A 1 130 ? -34.226 -10.627 11.032 1.00 65.05  ? 156 PHE A O   1 
ATOM   985  C CB  . PHE A 1 130 ? -35.179 -13.737 10.803 1.00 60.92  ? 156 PHE A CB  1 
ATOM   986  C CG  . PHE A 1 130 ? -35.058 -14.966 9.972  1.00 64.57  ? 156 PHE A CG  1 
ATOM   987  C CD1 . PHE A 1 130 ? -34.747 -14.864 8.623  1.00 64.35  ? 156 PHE A CD1 1 
ATOM   988  C CD2 . PHE A 1 130 ? -35.223 -16.223 10.536 1.00 62.38  ? 156 PHE A CD2 1 
ATOM   989  C CE1 . PHE A 1 130 ? -34.624 -15.985 7.844  1.00 64.93  ? 156 PHE A CE1 1 
ATOM   990  C CE2 . PHE A 1 130 ? -35.103 -17.356 9.757  1.00 65.40  ? 156 PHE A CE2 1 
ATOM   991  C CZ  . PHE A 1 130 ? -34.805 -17.237 8.411  1.00 62.59  ? 156 PHE A CZ  1 
ATOM   992  N N   . TYR A 1 131 ? -34.157 -11.713 13.000 1.00 59.38  ? 157 TYR A N   1 
ATOM   993  C CA  . TYR A 1 131 ? -34.422 -10.528 13.800 1.00 61.99  ? 157 TYR A CA  1 
ATOM   994  C C   . TYR A 1 131 ? -33.548 -10.528 15.049 1.00 61.92  ? 157 TYR A C   1 
ATOM   995  O O   . TYR A 1 131 ? -33.379 -11.565 15.702 1.00 59.06  ? 157 TYR A O   1 
ATOM   996  C CB  . TYR A 1 131 ? -35.915 -10.465 14.205 1.00 61.87  ? 157 TYR A CB  1 
ATOM   997  C CG  . TYR A 1 131 ? -36.887 -10.654 13.046 1.00 67.76  ? 157 TYR A CG  1 
ATOM   998  C CD1 . TYR A 1 131 ? -36.958 -9.718  12.014 1.00 69.07  ? 157 TYR A CD1 1 
ATOM   999  C CD2 . TYR A 1 131 ? -37.723 -11.766 12.982 1.00 67.46  ? 157 TYR A CD2 1 
ATOM   1000 C CE1 . TYR A 1 131 ? -37.829 -9.880  10.951 1.00 66.53  ? 157 TYR A CE1 1 
ATOM   1001 C CE2 . TYR A 1 131 ? -38.608 -11.945 11.910 1.00 73.00  ? 157 TYR A CE2 1 
ATOM   1002 C CZ  . TYR A 1 131 ? -38.652 -10.993 10.905 1.00 72.53  ? 157 TYR A CZ  1 
ATOM   1003 O OH  . TYR A 1 131 ? -39.514 -11.146 9.850  1.00 72.10  ? 157 TYR A OH  1 
ATOM   1004 N N   . ALA A 1 132 ? -33.004 -9.359  15.379 1.00 58.18  ? 158 ALA A N   1 
ATOM   1005 C CA  . ALA A 1 132 ? -32.439 -9.089  16.694 1.00 61.70  ? 158 ALA A CA  1 
ATOM   1006 C C   . ALA A 1 132 ? -33.150 -7.879  17.291 1.00 57.25  ? 158 ALA A C   1 
ATOM   1007 O O   . ALA A 1 132 ? -33.311 -6.852  16.630 1.00 57.97  ? 158 ALA A O   1 
ATOM   1008 C CB  . ALA A 1 132 ? -30.925 -8.852  16.623 1.00 54.98  ? 158 ALA A CB  1 
ATOM   1009 N N   . PHE A 1 133 ? -33.585 -8.005  18.529 1.00 58.13  ? 159 PHE A N   1 
ATOM   1010 C CA  . PHE A 1 133 ? -34.198 -6.887  19.211 1.00 58.92  ? 159 PHE A CA  1 
ATOM   1011 C C   . PHE A 1 133 ? -33.864 -7.034  20.684 1.00 57.33  ? 159 PHE A C   1 
ATOM   1012 O O   . PHE A 1 133 ? -33.229 -8.008  21.091 1.00 59.85  ? 159 PHE A O   1 
ATOM   1013 C CB  . PHE A 1 133 ? -35.708 -6.864  18.947 1.00 60.70  ? 159 PHE A CB  1 
ATOM   1014 C CG  . PHE A 1 133 ? -36.417 -8.112  19.405 1.00 56.53  ? 159 PHE A CG  1 
ATOM   1015 C CD1 . PHE A 1 133 ? -36.906 -8.205  20.696 1.00 56.03  ? 159 PHE A CD1 1 
ATOM   1016 C CD2 . PHE A 1 133 ? -36.591 -9.191  18.542 1.00 53.44  ? 159 PHE A CD2 1 
ATOM   1017 C CE1 . PHE A 1 133 ? -37.573 -9.344  21.122 1.00 62.61  ? 159 PHE A CE1 1 
ATOM   1018 C CE2 . PHE A 1 133 ? -37.223 -10.340 18.963 1.00 52.39  ? 159 PHE A CE2 1 
ATOM   1019 C CZ  . PHE A 1 133 ? -37.721 -10.420 20.248 1.00 61.93  ? 159 PHE A CZ  1 
ATOM   1020 N N   . GLN A 1 134 ? -34.339 -6.094  21.498 1.00 57.42  ? 160 GLN A N   1 
ATOM   1021 C CA  . GLN A 1 134 ? -34.015 -6.132  22.916 1.00 59.96  ? 160 GLN A CA  1 
ATOM   1022 C C   . GLN A 1 134 ? -35.137 -5.514  23.723 1.00 60.66  ? 160 GLN A C   1 
ATOM   1023 O O   . GLN A 1 134 ? -35.958 -4.762  23.202 1.00 61.12  ? 160 GLN A O   1 
ATOM   1024 C CB  . GLN A 1 134 ? -32.722 -5.386  23.229 1.00 53.54  ? 160 GLN A CB  1 
ATOM   1025 C CG  . GLN A 1 134 ? -32.678 -4.006  22.641 1.00 53.94  ? 160 GLN A CG  1 
ATOM   1026 C CD  . GLN A 1 134 ? -31.320 -3.378  22.832 1.00 59.63  ? 160 GLN A CD  1 
ATOM   1027 O OE1 . GLN A 1 134 ? -30.853 -3.240  23.961 1.00 61.28  ? 160 GLN A OE1 1 
ATOM   1028 N NE2 . GLN A 1 134 ? -30.657 -3.044  21.738 1.00 52.04  ? 160 GLN A NE2 1 
ATOM   1029 N N   . ASP A 1 135 ? -35.134 -5.827  25.020 1.00 63.61  ? 161 ASP A N   1 
ATOM   1030 C CA  . ASP A 1 135 ? -35.884 -5.060  26.005 1.00 62.90  ? 161 ASP A CA  1 
ATOM   1031 C C   . ASP A 1 135 ? -34.949 -4.753  27.181 1.00 68.67  ? 161 ASP A C   1 
ATOM   1032 O O   . ASP A 1 135 ? -33.736 -5.010  27.105 1.00 66.22  ? 161 ASP A O   1 
ATOM   1033 C CB  . ASP A 1 135 ? -37.168 -5.795  26.435 1.00 56.92  ? 161 ASP A CB  1 
ATOM   1034 C CG  . ASP A 1 135 ? -36.896 -7.123  27.156 1.00 67.33  ? 161 ASP A CG  1 
ATOM   1035 O OD1 . ASP A 1 135 ? -35.803 -7.311  27.748 1.00 67.48  ? 161 ASP A OD1 1 
ATOM   1036 O OD2 . ASP A 1 135 ? -37.801 -7.991  27.149 1.00 67.89  ? 161 ASP A OD2 1 
ATOM   1037 N N   . ASP A 1 136 ? -35.478 -4.189  28.267 1.00 63.31  ? 162 ASP A N   1 
ATOM   1038 C CA  . ASP A 1 136 ? -34.576 -3.707  29.304 1.00 67.42  ? 162 ASP A CA  1 
ATOM   1039 C C   . ASP A 1 136 ? -33.822 -4.832  30.003 1.00 68.39  ? 162 ASP A C   1 
ATOM   1040 O O   . ASP A 1 136 ? -32.797 -4.566  30.627 1.00 68.59  ? 162 ASP A O   1 
ATOM   1041 C CB  . ASP A 1 136 ? -35.335 -2.850  30.318 1.00 66.72  ? 162 ASP A CB  1 
ATOM   1042 C CG  . ASP A 1 136 ? -36.418 -3.621  31.055 1.00 75.07  ? 162 ASP A CG  1 
ATOM   1043 O OD1 . ASP A 1 136 ? -37.122 -4.439  30.425 1.00 73.27  ? 162 ASP A OD1 1 
ATOM   1044 O OD2 . ASP A 1 136 ? -36.564 -3.395  32.277 1.00 83.30  ? 162 ASP A OD2 1 
ATOM   1045 N N   . ARG A 1 137 ? -34.252 -6.085  29.863 1.00 69.31  ? 163 ARG A N   1 
ATOM   1046 C CA  . ARG A 1 137 ? -33.574 -7.185  30.536 1.00 67.00  ? 163 ARG A CA  1 
ATOM   1047 C C   . ARG A 1 137 ? -32.771 -8.103  29.618 1.00 67.06  ? 163 ARG A C   1 
ATOM   1048 O O   . ARG A 1 137 ? -31.761 -8.655  30.068 1.00 66.71  ? 163 ARG A O   1 
ATOM   1049 C CB  . ARG A 1 137 ? -34.597 -8.032  31.301 1.00 73.39  ? 163 ARG A CB  1 
ATOM   1050 C CG  . ARG A 1 137 ? -35.825 -7.251  31.713 1.00 80.67  ? 163 ARG A CG  1 
ATOM   1051 C CD  . ARG A 1 137 ? -36.941 -8.186  32.117 1.00 89.25  ? 163 ARG A CD  1 
ATOM   1052 N NE  . ARG A 1 137 ? -36.454 -9.220  33.023 1.00 94.42  ? 163 ARG A NE  1 
ATOM   1053 C CZ  . ARG A 1 137 ? -36.399 -9.085  34.343 1.00 99.69  ? 163 ARG A CZ  1 
ATOM   1054 N NH1 . ARG A 1 137 ? -36.810 -7.956  34.906 1.00 100.03 ? 163 ARG A NH1 1 
ATOM   1055 N NH2 . ARG A 1 137 ? -35.937 -10.079 35.096 1.00 101.30 ? 163 ARG A NH2 1 
ATOM   1056 N N   . TYR A 1 138 ? -33.164 -8.269  28.349 1.00 60.16  ? 164 TYR A N   1 
ATOM   1057 C CA  . TYR A 1 138 ? -32.616 -9.332  27.508 1.00 63.13  ? 164 TYR A CA  1 
ATOM   1058 C C   . TYR A 1 138 ? -32.284 -8.831  26.113 1.00 60.18  ? 164 TYR A C   1 
ATOM   1059 O O   . TYR A 1 138 ? -32.954 -7.945  25.574 1.00 60.40  ? 164 TYR A O   1 
ATOM   1060 C CB  . TYR A 1 138 ? -33.586 -10.509 27.334 1.00 62.08  ? 164 TYR A CB  1 
ATOM   1061 C CG  . TYR A 1 138 ? -33.788 -11.342 28.570 1.00 63.43  ? 164 TYR A CG  1 
ATOM   1062 C CD1 . TYR A 1 138 ? -32.821 -12.255 28.985 1.00 64.48  ? 164 TYR A CD1 1 
ATOM   1063 C CD2 . TYR A 1 138 ? -34.954 -11.229 29.314 1.00 68.39  ? 164 TYR A CD2 1 
ATOM   1064 C CE1 . TYR A 1 138 ? -33.005 -13.023 30.126 1.00 63.63  ? 164 TYR A CE1 1 
ATOM   1065 C CE2 . TYR A 1 138 ? -35.152 -11.988 30.455 1.00 68.56  ? 164 TYR A CE2 1 
ATOM   1066 C CZ  . TYR A 1 138 ? -34.182 -12.885 30.857 1.00 72.11  ? 164 TYR A CZ  1 
ATOM   1067 O OH  . TYR A 1 138 ? -34.390 -13.644 31.996 1.00 85.41  ? 164 TYR A OH  1 
ATOM   1068 N N   . LEU A 1 139 ? -31.237 -9.418  25.534 1.00 58.21  ? 165 LEU A N   1 
ATOM   1069 C CA  . LEU A 1 139 ? -31.053 -9.432  24.087 1.00 58.10  ? 165 LEU A CA  1 
ATOM   1070 C C   . LEU A 1 139 ? -31.833 -10.612 23.521 1.00 58.14  ? 165 LEU A C   1 
ATOM   1071 O O   . LEU A 1 139 ? -31.989 -11.641 24.186 1.00 55.36  ? 165 LEU A O   1 
ATOM   1072 C CB  . LEU A 1 139 ? -29.576 -9.559  23.700 1.00 55.16  ? 165 LEU A CB  1 
ATOM   1073 C CG  . LEU A 1 139 ? -28.593 -8.503  24.205 1.00 56.82  ? 165 LEU A CG  1 
ATOM   1074 C CD1 . LEU A 1 139 ? -27.169 -8.802  23.676 1.00 56.03  ? 165 LEU A CD1 1 
ATOM   1075 C CD2 . LEU A 1 139 ? -29.043 -7.093  23.797 1.00 56.05  ? 165 LEU A CD2 1 
ATOM   1076 N N   . TYR A 1 140 ? -32.313 -10.466 22.284 1.00 56.75  ? 166 TYR A N   1 
ATOM   1077 C CA  . TYR A 1 140 ? -33.056 -11.527 21.617 1.00 55.91  ? 166 TYR A CA  1 
ATOM   1078 C C   . TYR A 1 140 ? -32.513 -11.747 20.218 1.00 57.38  ? 166 TYR A C   1 
ATOM   1079 O O   . TYR A 1 140 ? -32.377 -10.795 19.448 1.00 61.65  ? 166 TYR A O   1 
ATOM   1080 C CB  . TYR A 1 140 ? -34.548 -11.184 21.499 1.00 58.30  ? 166 TYR A CB  1 
ATOM   1081 C CG  . TYR A 1 140 ? -35.280 -11.054 22.795 1.00 58.55  ? 166 TYR A CG  1 
ATOM   1082 C CD1 . TYR A 1 140 ? -35.293 -9.849  23.487 1.00 62.88  ? 166 TYR A CD1 1 
ATOM   1083 C CD2 . TYR A 1 140 ? -35.994 -12.124 23.323 1.00 61.32  ? 166 TYR A CD2 1 
ATOM   1084 C CE1 . TYR A 1 140 ? -35.990 -9.717  24.687 1.00 60.32  ? 166 TYR A CE1 1 
ATOM   1085 C CE2 . TYR A 1 140 ? -36.691 -12.002 24.523 1.00 60.16  ? 166 TYR A CE2 1 
ATOM   1086 C CZ  . TYR A 1 140 ? -36.683 -10.799 25.200 1.00 62.57  ? 166 TYR A CZ  1 
ATOM   1087 O OH  . TYR A 1 140 ? -37.364 -10.666 26.394 1.00 63.03  ? 166 TYR A OH  1 
ATOM   1088 N N   . MET A 1 141 ? -32.267 -13.000 19.863 1.00 55.13  ? 167 MET A N   1 
ATOM   1089 C CA  . MET A 1 141 ? -31.861 -13.350 18.506 1.00 60.27  ? 167 MET A CA  1 
ATOM   1090 C C   . MET A 1 141 ? -32.841 -14.375 17.962 1.00 51.63  ? 167 MET A C   1 
ATOM   1091 O O   . MET A 1 141 ? -32.963 -15.468 18.523 1.00 53.01  ? 167 MET A O   1 
ATOM   1092 C CB  . MET A 1 141 ? -30.439 -13.893 18.489 1.00 55.75  ? 167 MET A CB  1 
ATOM   1093 C CG  . MET A 1 141 ? -29.458 -12.842 18.908 1.00 64.65  ? 167 MET A CG  1 
ATOM   1094 S SD  . MET A 1 141 ? -27.766 -13.435 18.754 1.00 69.87  ? 167 MET A SD  1 
ATOM   1095 C CE  . MET A 1 141 ? -27.601 -14.334 20.272 1.00 60.61  ? 167 MET A CE  1 
ATOM   1096 N N   . VAL A 1 142 ? -33.526 -14.021 16.873 1.00 56.09  ? 168 VAL A N   1 
ATOM   1097 C CA  . VAL A 1 142 ? -34.548 -14.864 16.257 1.00 60.70  ? 168 VAL A CA  1 
ATOM   1098 C C   . VAL A 1 142 ? -33.944 -15.560 15.041 1.00 55.24  ? 168 VAL A C   1 
ATOM   1099 O O   . VAL A 1 142 ? -33.633 -14.923 14.030 1.00 55.78  ? 168 VAL A O   1 
ATOM   1100 C CB  . VAL A 1 142 ? -35.786 -14.050 15.874 1.00 61.82  ? 168 VAL A CB  1 
ATOM   1101 C CG1 . VAL A 1 142 ? -36.660 -14.858 14.948 1.00 62.78  ? 168 VAL A CG1 1 
ATOM   1102 C CG2 . VAL A 1 142 ? -36.547 -13.659 17.134 1.00 61.41  ? 168 VAL A CG2 1 
ATOM   1103 N N   . MET A 1 143 ? -33.810 -16.880 15.140 1.00 60.55  ? 169 MET A N   1 
ATOM   1104 C CA  . MET A 1 143 ? -33.089 -17.713 14.192 1.00 58.46  ? 169 MET A CA  1 
ATOM   1105 C C   . MET A 1 143 ? -34.028 -18.715 13.546 1.00 60.05  ? 169 MET A C   1 
ATOM   1106 O O   . MET A 1 143 ? -35.083 -19.046 14.099 1.00 50.46  ? 169 MET A O   1 
ATOM   1107 C CB  . MET A 1 143 ? -31.988 -18.501 14.905 1.00 49.37  ? 169 MET A CB  1 
ATOM   1108 C CG  . MET A 1 143 ? -30.958 -17.628 15.593 1.00 62.11  ? 169 MET A CG  1 
ATOM   1109 S SD  . MET A 1 143 ? -29.917 -18.618 16.691 1.00 59.99  ? 169 MET A SD  1 
ATOM   1110 C CE  . MET A 1 143 ? -31.007 -18.872 18.105 1.00 59.12  ? 169 MET A CE  1 
ATOM   1111 N N   . GLU A 1 144 ? -33.597 -19.266 12.412 1.00 54.69  ? 170 GLU A N   1 
ATOM   1112 C CA  . GLU A 1 144 ? -34.324 -20.409 11.889 1.00 57.34  ? 170 GLU A CA  1 
ATOM   1113 C C   . GLU A 1 144 ? -34.215 -21.558 12.876 1.00 59.27  ? 170 GLU A C   1 
ATOM   1114 O O   . GLU A 1 144 ? -33.178 -21.761 13.524 1.00 59.52  ? 170 GLU A O   1 
ATOM   1115 C CB  . GLU A 1 144 ? -33.816 -20.824 10.499 1.00 61.01  ? 170 GLU A CB  1 
ATOM   1116 C CG  . GLU A 1 144 ? -32.329 -21.148 10.388 1.00 66.28  ? 170 GLU A CG  1 
ATOM   1117 C CD  . GLU A 1 144 ? -31.876 -21.348 8.926  1.00 70.24  ? 170 GLU A CD  1 
ATOM   1118 O OE1 . GLU A 1 144 ? -30.664 -21.190 8.657  1.00 64.53  ? 170 GLU A OE1 1 
ATOM   1119 O OE2 . GLU A 1 144 ? -32.724 -21.653 8.045  1.00 78.65  ? 170 GLU A OE2 1 
ATOM   1120 N N   . TYR A 1 145 ? -35.320 -22.267 13.036 1.00 51.13  ? 171 TYR A N   1 
ATOM   1121 C CA  . TYR A 1 145 ? -35.398 -23.402 13.938 1.00 52.41  ? 171 TYR A CA  1 
ATOM   1122 C C   . TYR A 1 145 ? -34.765 -24.601 13.254 1.00 55.35  ? 171 TYR A C   1 
ATOM   1123 O O   . TYR A 1 145 ? -35.030 -24.859 12.076 1.00 57.94  ? 171 TYR A O   1 
ATOM   1124 C CB  . TYR A 1 145 ? -36.859 -23.685 14.300 1.00 53.35  ? 171 TYR A CB  1 
ATOM   1125 C CG  . TYR A 1 145 ? -37.060 -24.937 15.114 1.00 55.52  ? 171 TYR A CG  1 
ATOM   1126 C CD1 . TYR A 1 145 ? -36.211 -25.227 16.172 1.00 47.65  ? 171 TYR A CD1 1 
ATOM   1127 C CD2 . TYR A 1 145 ? -38.109 -25.826 14.841 1.00 51.08  ? 171 TYR A CD2 1 
ATOM   1128 C CE1 . TYR A 1 145 ? -36.371 -26.376 16.936 1.00 54.81  ? 171 TYR A CE1 1 
ATOM   1129 C CE2 . TYR A 1 145 ? -38.284 -26.992 15.626 1.00 49.90  ? 171 TYR A CE2 1 
ATOM   1130 C CZ  . TYR A 1 145 ? -37.416 -27.251 16.667 1.00 53.87  ? 171 TYR A CZ  1 
ATOM   1131 O OH  . TYR A 1 145 ? -37.541 -28.386 17.454 1.00 54.95  ? 171 TYR A OH  1 
ATOM   1132 N N   . MET A 1 146 ? -33.890 -25.304 13.974 1.00 54.67  ? 172 MET A N   1 
ATOM   1133 C CA  . MET A 1 146 ? -33.197 -26.485 13.465 1.00 53.30  ? 172 MET A CA  1 
ATOM   1134 C C   . MET A 1 146 ? -33.815 -27.720 14.101 1.00 50.37  ? 172 MET A C   1 
ATOM   1135 O O   . MET A 1 146 ? -33.349 -28.168 15.153 1.00 51.60  ? 172 MET A O   1 
ATOM   1136 C CB  . MET A 1 146 ? -31.697 -26.409 13.787 1.00 56.44  ? 172 MET A CB  1 
ATOM   1137 C CG  . MET A 1 146 ? -31.012 -25.218 13.148 1.00 53.63  ? 172 MET A CG  1 
ATOM   1138 S SD  . MET A 1 146 ? -31.007 -25.370 11.362 1.00 56.81  ? 172 MET A SD  1 
ATOM   1139 C CE  . MET A 1 146 ? -29.876 -26.728 11.164 1.00 56.49  ? 172 MET A CE  1 
ATOM   1140 N N   . PRO A 1 147 ? -34.829 -28.343 13.484 1.00 56.09  ? 173 PRO A N   1 
ATOM   1141 C CA  . PRO A 1 147 ? -35.588 -29.385 14.200 1.00 51.27  ? 173 PRO A CA  1 
ATOM   1142 C C   . PRO A 1 147 ? -34.885 -30.736 14.309 1.00 53.48  ? 173 PRO A C   1 
ATOM   1143 O O   . PRO A 1 147 ? -35.331 -31.581 15.105 1.00 50.54  ? 173 PRO A O   1 
ATOM   1144 C CB  . PRO A 1 147 ? -36.885 -29.506 13.375 1.00 49.43  ? 173 PRO A CB  1 
ATOM   1145 C CG  . PRO A 1 147 ? -36.517 -29.056 11.991 1.00 50.64  ? 173 PRO A CG  1 
ATOM   1146 C CD  . PRO A 1 147 ? -35.368 -28.064 12.131 1.00 49.32  ? 173 PRO A CD  1 
ATOM   1147 N N   . GLY A 1 148 ? -33.804 -30.978 13.560 1.00 51.48  ? 174 GLY A N   1 
ATOM   1148 C CA  . GLY A 1 148 ? -33.096 -32.253 13.708 1.00 46.32  ? 174 GLY A CA  1 
ATOM   1149 C C   . GLY A 1 148 ? -32.365 -32.437 15.023 1.00 50.15  ? 174 GLY A C   1 
ATOM   1150 O O   . GLY A 1 148 ? -31.895 -33.547 15.291 1.00 55.66  ? 174 GLY A O   1 
ATOM   1151 N N   . GLY A 1 149 ? -32.326 -31.413 15.888 1.00 46.07  ? 175 GLY A N   1 
ATOM   1152 C CA  . GLY A 1 149 ? -31.575 -31.532 17.125 1.00 55.60  ? 175 GLY A CA  1 
ATOM   1153 C C   . GLY A 1 149 ? -30.084 -31.358 16.865 1.00 51.43  ? 175 GLY A C   1 
ATOM   1154 O O   . GLY A 1 149 ? -29.671 -30.982 15.774 1.00 49.75  ? 175 GLY A O   1 
ATOM   1155 N N   . ASP A 1 150 ? -29.270 -31.637 17.887 1.00 56.99  ? 176 ASP A N   1 
ATOM   1156 C CA  . ASP A 1 150 ? -27.830 -31.436 17.774 1.00 58.91  ? 176 ASP A CA  1 
ATOM   1157 C C   . ASP A 1 150 ? -27.103 -32.778 17.760 1.00 60.95  ? 176 ASP A C   1 
ATOM   1158 O O   . ASP A 1 150 ? -27.711 -33.838 17.930 1.00 55.64  ? 176 ASP A O   1 
ATOM   1159 C CB  . ASP A 1 150 ? -27.323 -30.492 18.877 1.00 57.58  ? 176 ASP A CB  1 
ATOM   1160 C CG  . ASP A 1 150 ? -27.444 -31.063 20.308 1.00 58.46  ? 176 ASP A CG  1 
ATOM   1161 O OD1 . ASP A 1 150 ? -27.443 -32.302 20.508 1.00 61.18  ? 176 ASP A OD1 1 
ATOM   1162 O OD2 . ASP A 1 150 ? -27.500 -30.241 21.269 1.00 58.57  ? 176 ASP A OD2 1 
ATOM   1163 N N   . LEU A 1 151 ? -25.771 -32.723 17.595 1.00 54.52  ? 177 LEU A N   1 
ATOM   1164 C CA  . LEU A 1 151 ? -25.007 -33.955 17.423 1.00 54.88  ? 177 LEU A CA  1 
ATOM   1165 C C   . LEU A 1 151 ? -24.819 -34.722 18.729 1.00 53.62  ? 177 LEU A C   1 
ATOM   1166 O O   . LEU A 1 151 ? -24.617 -35.943 18.697 1.00 59.36  ? 177 LEU A O   1 
ATOM   1167 C CB  . LEU A 1 151 ? -23.639 -33.632 16.788 1.00 56.45  ? 177 LEU A CB  1 
ATOM   1168 C CG  . LEU A 1 151 ? -23.468 -33.829 15.283 1.00 54.01  ? 177 LEU A CG  1 
ATOM   1169 C CD1 . LEU A 1 151 ? -23.633 -35.293 14.949 1.00 55.00  ? 177 LEU A CD1 1 
ATOM   1170 C CD2 . LEU A 1 151 ? -24.464 -33.000 14.486 1.00 58.91  ? 177 LEU A CD2 1 
ATOM   1171 N N   . VAL A 1 152 ? -24.893 -34.042 19.873 1.00 56.00  ? 178 VAL A N   1 
ATOM   1172 C CA  . VAL A 1 152 ? -24.921 -34.731 21.161 1.00 55.05  ? 178 VAL A CA  1 
ATOM   1173 C C   . VAL A 1 152 ? -26.112 -35.679 21.223 1.00 60.99  ? 178 VAL A C   1 
ATOM   1174 O O   . VAL A 1 152 ? -25.986 -36.861 21.589 1.00 57.11  ? 178 VAL A O   1 
ATOM   1175 C CB  . VAL A 1 152 ? -24.955 -33.709 22.308 1.00 59.51  ? 178 VAL A CB  1 
ATOM   1176 C CG1 . VAL A 1 152 ? -25.076 -34.426 23.694 1.00 51.90  ? 178 VAL A CG1 1 
ATOM   1177 C CG2 . VAL A 1 152 ? -23.730 -32.818 22.239 1.00 60.67  ? 178 VAL A CG2 1 
ATOM   1178 N N   . ASN A 1 153 ? -27.286 -35.178 20.845 1.00 56.11  ? 179 ASN A N   1 
ATOM   1179 C CA  . ASN A 1 153 ? -28.479 -36.016 20.887 1.00 62.20  ? 179 ASN A CA  1 
ATOM   1180 C C   . ASN A 1 153 ? -28.367 -37.179 19.895 1.00 58.78  ? 179 ASN A C   1 
ATOM   1181 O O   . ASN A 1 153 ? -28.703 -38.321 20.230 1.00 65.15  ? 179 ASN A O   1 
ATOM   1182 C CB  . ASN A 1 153 ? -29.716 -35.143 20.620 1.00 64.47  ? 179 ASN A CB  1 
ATOM   1183 C CG  . ASN A 1 153 ? -30.993 -35.960 20.432 1.00 64.18  ? 179 ASN A CG  1 
ATOM   1184 O OD1 . ASN A 1 153 ? -31.414 -36.224 19.295 1.00 67.53  ? 179 ASN A OD1 1 
ATOM   1185 N ND2 . ASN A 1 153 ? -31.612 -36.358 21.540 1.00 62.64  ? 179 ASN A ND2 1 
ATOM   1186 N N   . LEU A 1 154 ? -27.825 -36.929 18.704 1.00 57.55  ? 180 LEU A N   1 
ATOM   1187 C CA  . LEU A 1 154 ? -27.653 -38.005 17.730 1.00 53.74  ? 180 LEU A CA  1 
ATOM   1188 C C   . LEU A 1 154 ? -26.751 -39.109 18.272 1.00 60.55  ? 180 LEU A C   1 
ATOM   1189 O O   . LEU A 1 154 ? -27.084 -40.293 18.184 1.00 66.90  ? 180 LEU A O   1 
ATOM   1190 C CB  . LEU A 1 154 ? -27.081 -37.441 16.427 1.00 54.18  ? 180 LEU A CB  1 
ATOM   1191 C CG  . LEU A 1 154 ? -27.133 -38.378 15.192 1.00 57.57  ? 180 LEU A CG  1 
ATOM   1192 C CD1 . LEU A 1 154 ? -27.449 -37.606 13.937 1.00 57.50  ? 180 LEU A CD1 1 
ATOM   1193 C CD2 . LEU A 1 154 ? -25.853 -39.185 14.988 1.00 57.70  ? 180 LEU A CD2 1 
ATOM   1194 N N   . MET A 1 155 ? -25.596 -38.741 18.835 1.00 58.46  ? 181 MET A N   1 
ATOM   1195 C CA  . MET A 1 155 ? -24.663 -39.739 19.373 1.00 64.94  ? 181 MET A CA  1 
ATOM   1196 C C   . MET A 1 155 ? -25.251 -40.484 20.572 1.00 66.64  ? 181 MET A C   1 
ATOM   1197 O O   . MET A 1 155 ? -24.985 -41.679 20.757 1.00 67.87  ? 181 MET A O   1 
ATOM   1198 C CB  . MET A 1 155 ? -23.348 -39.071 19.794 1.00 54.44  ? 181 MET A CB  1 
ATOM   1199 C CG  . MET A 1 155 ? -22.429 -38.682 18.641 1.00 68.21  ? 181 MET A CG  1 
ATOM   1200 S SD  . MET A 1 155 ? -20.940 -37.844 19.279 1.00 74.51  ? 181 MET A SD  1 
ATOM   1201 C CE  . MET A 1 155 ? -21.491 -36.156 19.181 1.00 54.57  ? 181 MET A CE  1 
ATOM   1202 N N   . SER A 1 156 ? -26.025 -39.799 21.420 1.00 62.02  ? 182 SER A N   1 
ATOM   1203 C CA  . SER A 1 156 ? -26.647 -40.514 22.533 1.00 68.00  ? 182 SER A CA  1 
ATOM   1204 C C   . SER A 1 156 ? -27.697 -41.520 22.052 1.00 70.40  ? 182 SER A C   1 
ATOM   1205 O O   . SER A 1 156 ? -27.965 -42.497 22.751 1.00 77.06  ? 182 SER A O   1 
ATOM   1206 C CB  . SER A 1 156 ? -27.245 -39.528 23.547 1.00 65.83  ? 182 SER A CB  1 
ATOM   1207 O OG  . SER A 1 156 ? -28.466 -38.972 23.081 1.00 71.36  ? 182 SER A OG  1 
ATOM   1208 N N   . ASN A 1 157 ? -28.261 -41.334 20.859 1.00 72.40  ? 183 ASN A N   1 
ATOM   1209 C CA  . ASN A 1 157 ? -29.333 -42.187 20.360 1.00 67.64  ? 183 ASN A CA  1 
ATOM   1210 C C   . ASN A 1 157 ? -28.848 -43.253 19.395 1.00 73.71  ? 183 ASN A C   1 
ATOM   1211 O O   . ASN A 1 157 ? -29.625 -44.149 19.050 1.00 74.60  ? 183 ASN A O   1 
ATOM   1212 C CB  . ASN A 1 157 ? -30.400 -41.343 19.653 1.00 67.66  ? 183 ASN A CB  1 
ATOM   1213 C CG  . ASN A 1 157 ? -31.253 -40.546 20.628 1.00 71.11  ? 183 ASN A CG  1 
ATOM   1214 O OD1 . ASN A 1 157 ? -31.382 -40.916 21.795 1.00 76.98  ? 183 ASN A OD1 1 
ATOM   1215 N ND2 . ASN A 1 157 ? -31.827 -39.446 20.160 1.00 72.67  ? 183 ASN A ND2 1 
ATOM   1216 N N   . TYR A 1 158 ? -27.605 -43.170 18.924 1.00 71.15  ? 184 TYR A N   1 
ATOM   1217 C CA  . TYR A 1 158 ? -27.130 -44.113 17.928 1.00 69.51  ? 184 TYR A CA  1 
ATOM   1218 C C   . TYR A 1 158 ? -25.717 -44.565 18.235 1.00 74.16  ? 184 TYR A C   1 
ATOM   1219 O O   . TYR A 1 158 ? -24.918 -43.836 18.835 1.00 72.48  ? 184 TYR A O   1 
ATOM   1220 C CB  . TYR A 1 158 ? -27.156 -43.514 16.521 1.00 69.69  ? 184 TYR A CB  1 
ATOM   1221 C CG  . TYR A 1 158 ? -28.542 -43.152 16.005 1.00 65.81  ? 184 TYR A CG  1 
ATOM   1222 C CD1 . TYR A 1 158 ? -29.310 -44.076 15.320 1.00 67.60  ? 184 TYR A CD1 1 
ATOM   1223 C CD2 . TYR A 1 158 ? -29.063 -41.873 16.183 1.00 64.38  ? 184 TYR A CD2 1 
ATOM   1224 C CE1 . TYR A 1 158 ? -30.576 -43.749 14.842 1.00 70.42  ? 184 TYR A CE1 1 
ATOM   1225 C CE2 . TYR A 1 158 ? -30.312 -41.533 15.705 1.00 65.93  ? 184 TYR A CE2 1 
ATOM   1226 C CZ  . TYR A 1 158 ? -31.073 -42.480 15.040 1.00 69.64  ? 184 TYR A CZ  1 
ATOM   1227 O OH  . TYR A 1 158 ? -32.325 -42.150 14.560 1.00 75.03  ? 184 TYR A OH  1 
ATOM   1228 N N   . ASP A 1 159 ? -25.406 -45.764 17.763 1.00 79.18  ? 185 ASP A N   1 
ATOM   1229 C CA  . ASP A 1 159 ? -24.027 -46.199 17.648 1.00 79.34  ? 185 ASP A CA  1 
ATOM   1230 C C   . ASP A 1 159 ? -23.615 -45.783 16.252 1.00 77.08  ? 185 ASP A C   1 
ATOM   1231 O O   . ASP A 1 159 ? -24.255 -46.180 15.274 1.00 75.89  ? 185 ASP A O   1 
ATOM   1232 C CB  . ASP A 1 159 ? -23.894 -47.713 17.792 1.00 83.47  ? 185 ASP A CB  1 
ATOM   1233 C CG  . ASP A 1 159 ? -23.846 -48.159 19.219 1.00 92.32  ? 185 ASP A CG  1 
ATOM   1234 O OD1 . ASP A 1 159 ? -24.172 -47.347 20.114 1.00 94.85  ? 185 ASP A OD1 1 
ATOM   1235 O OD2 . ASP A 1 159 ? -23.478 -49.329 19.447 1.00 103.60 ? 185 ASP A OD2 1 
ATOM   1236 N N   . VAL A 1 160 ? -22.587 -44.950 16.150 1.00 74.77  ? 186 VAL A N   1 
ATOM   1237 C CA  . VAL A 1 160 ? -22.332 -44.180 14.939 1.00 69.54  ? 186 VAL A CA  1 
ATOM   1238 C C   . VAL A 1 160 ? -21.364 -44.987 14.078 1.00 66.21  ? 186 VAL A C   1 
ATOM   1239 O O   . VAL A 1 160 ? -20.202 -45.153 14.473 1.00 73.73  ? 186 VAL A O   1 
ATOM   1240 C CB  . VAL A 1 160 ? -21.782 -42.787 15.261 1.00 71.83  ? 186 VAL A CB  1 
ATOM   1241 C CG1 . VAL A 1 160 ? -21.565 -41.996 13.984 1.00 65.77  ? 186 VAL A CG1 1 
ATOM   1242 C CG2 . VAL A 1 160 ? -22.731 -42.046 16.199 1.00 62.85  ? 186 VAL A CG2 1 
ATOM   1243 N N   . PRO A 1 161 ? -21.797 -45.543 12.954 1.00 64.10  ? 187 PRO A N   1 
ATOM   1244 C CA  . PRO A 1 161 ? -20.849 -46.214 12.065 1.00 66.97  ? 187 PRO A CA  1 
ATOM   1245 C C   . PRO A 1 161 ? -19.977 -45.200 11.334 1.00 66.48  ? 187 PRO A C   1 
ATOM   1246 O O   . PRO A 1 161 ? -20.328 -44.023 11.173 1.00 61.39  ? 187 PRO A O   1 
ATOM   1247 C CB  . PRO A 1 161 ? -21.754 -46.973 11.092 1.00 68.92  ? 187 PRO A CB  1 
ATOM   1248 C CG  . PRO A 1 161 ? -22.982 -46.114 11.003 1.00 67.03  ? 187 PRO A CG  1 
ATOM   1249 C CD  . PRO A 1 161 ? -23.152 -45.471 12.373 1.00 66.20  ? 187 PRO A CD  1 
ATOM   1250 N N   . GLU A 1 162 ? -18.829 -45.688 10.853 1.00 63.50  ? 188 GLU A N   1 
ATOM   1251 C CA  . GLU A 1 162 ? -17.863 -44.790 10.221 1.00 56.60  ? 188 GLU A CA  1 
ATOM   1252 C C   . GLU A 1 162 ? -18.450 -44.124 8.990  1.00 52.82  ? 188 GLU A C   1 
ATOM   1253 O O   . GLU A 1 162 ? -18.166 -42.947 8.721  1.00 57.34  ? 188 GLU A O   1 
ATOM   1254 C CB  . GLU A 1 162 ? -16.572 -45.548 9.867  1.00 59.85  ? 188 GLU A CB  1 
ATOM   1255 C CG  . GLU A 1 162 ? -15.879 -46.160 11.096 1.00 66.32  ? 188 GLU A CG  1 
ATOM   1256 C CD  . GLU A 1 162 ? -14.344 -46.392 10.937 1.00 68.76  ? 188 GLU A CD  1 
ATOM   1257 O OE1 . GLU A 1 162 ? -13.768 -46.170 9.839  1.00 62.66  ? 188 GLU A OE1 1 
ATOM   1258 O OE2 . GLU A 1 162 ? -13.728 -46.809 11.942 1.00 71.09  ? 188 GLU A OE2 1 
ATOM   1259 N N   . LYS A 1 163 ? -19.289 -44.840 8.233  1.00 54.71  ? 189 LYS A N   1 
ATOM   1260 C CA  . LYS A 1 163 ? -19.939 -44.209 7.077  1.00 59.37  ? 189 LYS A CA  1 
ATOM   1261 C C   . LYS A 1 163 ? -20.666 -42.921 7.480  1.00 53.17  ? 189 LYS A C   1 
ATOM   1262 O O   . LYS A 1 163 ? -20.676 -41.944 6.727  1.00 57.84  ? 189 LYS A O   1 
ATOM   1263 C CB  . LYS A 1 163 ? -20.911 -45.191 6.404  1.00 60.39  ? 189 LYS A CB  1 
ATOM   1264 N N   . TRP A 1 164 ? -21.251 -42.893 8.680  1.00 53.70  ? 190 TRP A N   1 
ATOM   1265 C CA  . TRP A 1 164 ? -21.921 -41.696 9.186  1.00 57.30  ? 190 TRP A CA  1 
ATOM   1266 C C   . TRP A 1 164 ? -20.926 -40.650 9.691  1.00 53.56  ? 190 TRP A C   1 
ATOM   1267 O O   . TRP A 1 164 ? -21.068 -39.449 9.417  1.00 51.58  ? 190 TRP A O   1 
ATOM   1268 C CB  . TRP A 1 164 ? -22.881 -42.083 10.305 1.00 56.79  ? 190 TRP A CB  1 
ATOM   1269 C CG  . TRP A 1 164 ? -24.106 -42.862 9.900  1.00 64.87  ? 190 TRP A CG  1 
ATOM   1270 C CD1 . TRP A 1 164 ? -24.343 -43.499 8.708  1.00 64.02  ? 190 TRP A CD1 1 
ATOM   1271 C CD2 . TRP A 1 164 ? -25.265 -43.081 10.712 1.00 59.96  ? 190 TRP A CD2 1 
ATOM   1272 N NE1 . TRP A 1 164 ? -25.578 -44.097 8.735  1.00 65.51  ? 190 TRP A NE1 1 
ATOM   1273 C CE2 . TRP A 1 164 ? -26.163 -43.862 9.955  1.00 63.76  ? 190 TRP A CE2 1 
ATOM   1274 C CE3 . TRP A 1 164 ? -25.625 -42.690 12.010 1.00 61.81  ? 190 TRP A CE3 1 
ATOM   1275 C CZ2 . TRP A 1 164 ? -27.414 -44.263 10.451 1.00 60.93  ? 190 TRP A CZ2 1 
ATOM   1276 C CZ3 . TRP A 1 164 ? -26.859 -43.099 12.513 1.00 71.29  ? 190 TRP A CZ3 1 
ATOM   1277 C CH2 . TRP A 1 164 ? -27.741 -43.878 11.730 1.00 67.17  ? 190 TRP A CH2 1 
ATOM   1278 N N   . ALA A 1 165 ? -19.958 -41.080 10.498 1.00 54.17  ? 191 ALA A N   1 
ATOM   1279 C CA  . ALA A 1 165 ? -18.952 -40.141 10.986 1.00 54.17  ? 191 ALA A CA  1 
ATOM   1280 C C   . ALA A 1 165 ? -18.233 -39.491 9.817  1.00 51.30  ? 191 ALA A C   1 
ATOM   1281 O O   . ALA A 1 165 ? -17.956 -38.284 9.840  1.00 56.05  ? 191 ALA A O   1 
ATOM   1282 C CB  . ALA A 1 165 ? -17.969 -40.858 11.914 1.00 55.93  ? 191 ALA A CB  1 
ATOM   1283 N N   . LYS A 1 166 ? -18.004 -40.267 8.755  1.00 51.74  ? 192 LYS A N   1 
ATOM   1284 C CA  . LYS A 1 166 ? -17.431 -39.757 7.513  1.00 54.43  ? 192 LYS A CA  1 
ATOM   1285 C C   . LYS A 1 166 ? -18.187 -38.529 7.033  1.00 56.96  ? 192 LYS A C   1 
ATOM   1286 O O   . LYS A 1 166 ? -17.600 -37.473 6.747  1.00 51.24  ? 192 LYS A O   1 
ATOM   1287 C CB  . LYS A 1 166 ? -17.521 -40.873 6.464  1.00 59.06  ? 192 LYS A CB  1 
ATOM   1288 C CG  . LYS A 1 166 ? -16.504 -40.889 5.370  1.00 65.21  ? 192 LYS A CG  1 
ATOM   1289 C CD  . LYS A 1 166 ? -16.355 -42.312 4.812  1.00 59.86  ? 192 LYS A CD  1 
ATOM   1290 C CE  . LYS A 1 166 ? -16.005 -43.288 5.928  1.00 60.74  ? 192 LYS A CE  1 
ATOM   1291 N NZ  . LYS A 1 166 ? -15.280 -44.450 5.336  1.00 60.96  ? 192 LYS A NZ  1 
ATOM   1292 N N   . PHE A 1 167 ? -19.515 -38.664 6.938  1.00 57.16  ? 193 PHE A N   1 
ATOM   1293 C CA  . PHE A 1 167 ? -20.367 -37.608 6.386  1.00 53.05  ? 193 PHE A CA  1 
ATOM   1294 C C   . PHE A 1 167 ? -20.412 -36.390 7.318  1.00 46.78  ? 193 PHE A C   1 
ATOM   1295 O O   . PHE A 1 167 ? -20.203 -35.251 6.882  1.00 51.24  ? 193 PHE A O   1 
ATOM   1296 C CB  . PHE A 1 167 ? -21.768 -38.209 6.127  1.00 55.80  ? 193 PHE A CB  1 
ATOM   1297 C CG  . PHE A 1 167 ? -22.839 -37.201 5.894  1.00 50.61  ? 193 PHE A CG  1 
ATOM   1298 C CD1 . PHE A 1 167 ? -23.388 -36.468 6.966  1.00 47.88  ? 193 PHE A CD1 1 
ATOM   1299 C CD2 . PHE A 1 167 ? -23.363 -37.032 4.616  1.00 49.82  ? 193 PHE A CD2 1 
ATOM   1300 C CE1 . PHE A 1 167 ? -24.377 -35.532 6.731  1.00 52.72  ? 193 PHE A CE1 1 
ATOM   1301 C CE2 . PHE A 1 167 ? -24.355 -36.105 4.377  1.00 51.88  ? 193 PHE A CE2 1 
ATOM   1302 C CZ  . PHE A 1 167 ? -24.868 -35.350 5.435  1.00 53.35  ? 193 PHE A CZ  1 
ATOM   1303 N N   . TYR A 1 168 ? -20.673 -36.610 8.608  1.00 48.31  ? 194 TYR A N   1 
ATOM   1304 C CA  . TYR A 1 168 ? -20.760 -35.488 9.553  1.00 54.41  ? 194 TYR A CA  1 
ATOM   1305 C C   . TYR A 1 168 ? -19.424 -34.764 9.723  1.00 53.33  ? 194 TYR A C   1 
ATOM   1306 O O   . TYR A 1 168 ? -19.392 -33.532 9.907  1.00 44.34  ? 194 TYR A O   1 
ATOM   1307 C CB  . TYR A 1 168 ? -21.258 -35.975 10.912 1.00 44.92  ? 194 TYR A CB  1 
ATOM   1308 C CG  . TYR A 1 168 ? -22.724 -36.440 10.873 1.00 52.37  ? 194 TYR A CG  1 
ATOM   1309 C CD1 . TYR A 1 168 ? -23.745 -35.571 10.545 1.00 45.98  ? 194 TYR A CD1 1 
ATOM   1310 C CD2 . TYR A 1 168 ? -23.052 -37.749 11.151 1.00 52.36  ? 194 TYR A CD2 1 
ATOM   1311 C CE1 . TYR A 1 168 ? -25.106 -36.025 10.500 1.00 55.64  ? 194 TYR A CE1 1 
ATOM   1312 C CE2 . TYR A 1 168 ? -24.325 -38.195 11.125 1.00 60.64  ? 194 TYR A CE2 1 
ATOM   1313 C CZ  . TYR A 1 168 ? -25.360 -37.345 10.799 1.00 55.09  ? 194 TYR A CZ  1 
ATOM   1314 O OH  . TYR A 1 168 ? -26.608 -37.888 10.804 1.00 54.13  ? 194 TYR A OH  1 
ATOM   1315 N N   . THR A 1 169 ? -18.311 -35.508 9.672  1.00 53.63  ? 195 THR A N   1 
ATOM   1316 C CA  . THR A 1 169 ? -17.002 -34.855 9.739  1.00 52.62  ? 195 THR A CA  1 
ATOM   1317 C C   . THR A 1 169 ? -16.805 -33.942 8.550  1.00 45.76  ? 195 THR A C   1 
ATOM   1318 O O   . THR A 1 169 ? -16.465 -32.761 8.708  1.00 50.26  ? 195 THR A O   1 
ATOM   1319 C CB  . THR A 1 169 ? -15.887 -35.895 9.804  1.00 55.42  ? 195 THR A CB  1 
ATOM   1320 O OG1 . THR A 1 169 ? -16.050 -36.655 11.010 1.00 47.29  ? 195 THR A OG1 1 
ATOM   1321 C CG2 . THR A 1 169 ? -14.512 -35.198 9.813  1.00 51.93  ? 195 THR A CG2 1 
ATOM   1322 N N   . ALA A 1 170 ? -17.124 -34.441 7.352  1.00 45.71  ? 196 ALA A N   1 
ATOM   1323 C CA  . ALA A 1 170 ? -16.974 -33.640 6.145  1.00 40.62  ? 196 ALA A CA  1 
ATOM   1324 C C   . ALA A 1 170 ? -17.829 -32.368 6.173  1.00 54.80  ? 196 ALA A C   1 
ATOM   1325 O O   . ALA A 1 170 ? -17.363 -31.290 5.754  1.00 47.77  ? 196 ALA A O   1 
ATOM   1326 C CB  . ALA A 1 170 ? -17.292 -34.506 4.920  1.00 47.15  ? 196 ALA A CB  1 
ATOM   1327 N N   . GLU A 1 171 ? -19.097 -32.466 6.630  1.00 45.01  ? 197 GLU A N   1 
ATOM   1328 C CA  . GLU A 1 171 ? -19.923 -31.255 6.689  1.00 48.03  ? 197 GLU A CA  1 
ATOM   1329 C C   . GLU A 1 171 ? -19.364 -30.257 7.702  1.00 40.83  ? 197 GLU A C   1 
ATOM   1330 O O   . GLU A 1 171 ? -19.375 -29.040 7.459  1.00 47.22  ? 197 GLU A O   1 
ATOM   1331 C CB  . GLU A 1 171 ? -21.391 -31.623 7.033  1.00 45.52  ? 197 GLU A CB  1 
ATOM   1332 C CG  . GLU A 1 171 ? -22.078 -32.575 5.988  1.00 44.62  ? 197 GLU A CG  1 
ATOM   1333 C CD  . GLU A 1 171 ? -23.611 -32.343 5.876  1.00 52.95  ? 197 GLU A CD  1 
ATOM   1334 O OE1 . GLU A 1 171 ? -24.240 -32.046 6.918  1.00 48.65  ? 197 GLU A OE1 1 
ATOM   1335 O OE2 . GLU A 1 171 ? -24.160 -32.443 4.759  1.00 49.02  ? 197 GLU A OE2 1 
ATOM   1336 N N   . VAL A 1 172 ? -18.902 -30.746 8.856  1.00 39.24  ? 198 VAL A N   1 
ATOM   1337 C CA  . VAL A 1 172 ? -18.262 -29.863 9.834  1.00 44.38  ? 198 VAL A CA  1 
ATOM   1338 C C   . VAL A 1 172 ? -17.047 -29.184 9.213  1.00 46.84  ? 198 VAL A C   1 
ATOM   1339 O O   . VAL A 1 172 ? -16.867 -27.963 9.340  1.00 48.01  ? 198 VAL A O   1 
ATOM   1340 C CB  . VAL A 1 172 ? -17.877 -30.643 11.108 1.00 50.45  ? 198 VAL A CB  1 
ATOM   1341 C CG1 . VAL A 1 172 ? -16.992 -29.802 12.021 1.00 52.87  ? 198 VAL A CG1 1 
ATOM   1342 C CG2 . VAL A 1 172 ? -19.100 -31.041 11.880 1.00 49.70  ? 198 VAL A CG2 1 
ATOM   1343 N N   . VAL A 1 173 ? -16.213 -29.960 8.508  1.00 47.23  ? 199 VAL A N   1 
ATOM   1344 C CA  . VAL A 1 173 ? -15.044 -29.387 7.824  1.00 52.92  ? 199 VAL A CA  1 
ATOM   1345 C C   . VAL A 1 173 ? -15.475 -28.297 6.849  1.00 55.16  ? 199 VAL A C   1 
ATOM   1346 O O   . VAL A 1 173 ? -14.888 -27.203 6.795  1.00 48.43  ? 199 VAL A O   1 
ATOM   1347 C CB  . VAL A 1 173 ? -14.250 -30.491 7.105  1.00 48.41  ? 199 VAL A CB  1 
ATOM   1348 C CG1 . VAL A 1 173 ? -13.147 -29.870 6.259  1.00 51.60  ? 199 VAL A CG1 1 
ATOM   1349 C CG2 . VAL A 1 173 ? -13.682 -31.436 8.111  1.00 49.47  ? 199 VAL A CG2 1 
ATOM   1350 N N   . LEU A 1 174 ? -16.516 -28.570 6.058  1.00 50.36  ? 200 LEU A N   1 
ATOM   1351 C CA  . LEU A 1 174 ? -16.946 -27.540 5.124  1.00 43.14  ? 200 LEU A CA  1 
ATOM   1352 C C   . LEU A 1 174 ? -17.540 -26.354 5.853  1.00 44.91  ? 200 LEU A C   1 
ATOM   1353 O O   . LEU A 1 174 ? -17.343 -25.208 5.432  1.00 47.22  ? 200 LEU A O   1 
ATOM   1354 C CB  . LEU A 1 174 ? -17.938 -28.122 4.115  1.00 47.96  ? 200 LEU A CB  1 
ATOM   1355 C CG  . LEU A 1 174 ? -17.350 -29.095 3.105  1.00 52.30  ? 200 LEU A CG  1 
ATOM   1356 C CD1 . LEU A 1 174 ? -18.443 -29.905 2.375  1.00 52.06  ? 200 LEU A CD1 1 
ATOM   1357 C CD2 . LEU A 1 174 ? -16.532 -28.291 2.115  1.00 51.15  ? 200 LEU A CD2 1 
ATOM   1358 N N   . ALA A 1 175 ? -18.331 -26.600 6.912  1.00 47.40  ? 201 ALA A N   1 
ATOM   1359 C CA  . ALA A 1 175 ? -18.885 -25.480 7.680  1.00 51.75  ? 201 ALA A CA  1 
ATOM   1360 C C   . ALA A 1 175 ? -17.773 -24.606 8.264  1.00 52.35  ? 201 ALA A C   1 
ATOM   1361 O O   . ALA A 1 175 ? -17.834 -23.369 8.211  1.00 51.35  ? 201 ALA A O   1 
ATOM   1362 C CB  . ALA A 1 175 ? -19.796 -26.001 8.803  1.00 49.12  ? 201 ALA A CB  1 
ATOM   1363 N N   . LEU A 1 176 ? -16.750 -25.234 8.841  1.00 53.45  ? 202 LEU A N   1 
ATOM   1364 C CA  . LEU A 1 176 ? -15.621 -24.470 9.381  1.00 53.77  ? 202 LEU A CA  1 
ATOM   1365 C C   . LEU A 1 176 ? -14.878 -23.733 8.282  1.00 53.60  ? 202 LEU A C   1 
ATOM   1366 O O   . LEU A 1 176 ? -14.445 -22.583 8.466  1.00 50.31  ? 202 LEU A O   1 
ATOM   1367 C CB  . LEU A 1 176 ? -14.665 -25.409 10.104 1.00 50.89  ? 202 LEU A CB  1 
ATOM   1368 C CG  . LEU A 1 176 ? -15.207 -25.815 11.456 1.00 50.62  ? 202 LEU A CG  1 
ATOM   1369 C CD1 . LEU A 1 176 ? -14.414 -26.952 12.053 1.00 48.27  ? 202 LEU A CD1 1 
ATOM   1370 C CD2 . LEU A 1 176 ? -15.248 -24.586 12.362 1.00 53.15  ? 202 LEU A CD2 1 
ATOM   1371 N N   . ASP A 1 177 ? -14.725 -24.371 7.117  1.00 49.00  ? 203 ASP A N   1 
ATOM   1372 C CA  . ASP A 1 177 ? -14.043 -23.688 6.019  1.00 56.94  ? 203 ASP A CA  1 
ATOM   1373 C C   . ASP A 1 177 ? -14.789 -22.432 5.591  1.00 61.08  ? 203 ASP A C   1 
ATOM   1374 O O   . ASP A 1 177 ? -14.172 -21.403 5.267  1.00 60.41  ? 203 ASP A O   1 
ATOM   1375 C CB  . ASP A 1 177 ? -13.863 -24.619 4.828  1.00 56.60  ? 203 ASP A CB  1 
ATOM   1376 C CG  . ASP A 1 177 ? -12.831 -24.083 3.837  1.00 64.01  ? 203 ASP A CG  1 
ATOM   1377 O OD1 . ASP A 1 177 ? -11.745 -23.635 4.290  1.00 66.44  ? 203 ASP A OD1 1 
ATOM   1378 O OD2 . ASP A 1 177 ? -13.104 -24.100 2.615  1.00 63.24  ? 203 ASP A OD2 1 
ATOM   1379 N N   . ALA A 1 178 ? -16.119 -22.480 5.616  1.00 54.87  ? 204 ALA A N   1 
ATOM   1380 C CA  . ALA A 1 178 ? -16.888 -21.287 5.284  1.00 56.92  ? 204 ALA A CA  1 
ATOM   1381 C C   . ALA A 1 178 ? -16.704 -20.207 6.345  1.00 53.55  ? 204 ALA A C   1 
ATOM   1382 O O   . ALA A 1 178 ? -16.626 -19.018 6.021  1.00 57.56  ? 204 ALA A O   1 
ATOM   1383 C CB  . ALA A 1 178 ? -18.373 -21.654 5.096  1.00 54.27  ? 204 ALA A CB  1 
ATOM   1384 N N   . ILE A 1 179 ? -16.677 -20.591 7.621  1.00 52.70  ? 205 ILE A N   1 
ATOM   1385 C CA  . ILE A 1 179 ? -16.400 -19.622 8.682  1.00 52.20  ? 205 ILE A CA  1 
ATOM   1386 C C   . ILE A 1 179 ? -15.023 -18.981 8.466  1.00 57.18  ? 205 ILE A C   1 
ATOM   1387 O O   . ILE A 1 179 ? -14.867 -17.757 8.511  1.00 53.73  ? 205 ILE A O   1 
ATOM   1388 C CB  . ILE A 1 179 ? -16.493 -20.302 10.060 1.00 60.60  ? 205 ILE A CB  1 
ATOM   1389 C CG1 . ILE A 1 179 ? -17.935 -20.722 10.381 1.00 65.15  ? 205 ILE A CG1 1 
ATOM   1390 C CG2 . ILE A 1 179 ? -15.914 -19.405 11.151 1.00 58.29  ? 205 ILE A CG2 1 
ATOM   1391 C CD1 . ILE A 1 179 ? -18.927 -19.582 10.373 1.00 59.91  ? 205 ILE A CD1 1 
ATOM   1392 N N   . HIS A 1 180 ? -14.008 -19.806 8.207  1.00 52.70  ? 206 HIS A N   1 
ATOM   1393 C CA  . HIS A 1 180 ? -12.671 -19.266 7.966  1.00 57.64  ? 206 HIS A CA  1 
ATOM   1394 C C   . HIS A 1 180 ? -12.670 -18.284 6.797  1.00 63.46  ? 206 HIS A C   1 
ATOM   1395 O O   . HIS A 1 180 ? -12.116 -17.184 6.914  1.00 58.14  ? 206 HIS A O   1 
ATOM   1396 C CB  . HIS A 1 180 ? -11.690 -20.418 7.756  1.00 49.75  ? 206 HIS A CB  1 
ATOM   1397 C CG  . HIS A 1 180 ? -11.586 -21.307 8.959  1.00 50.57  ? 206 HIS A CG  1 
ATOM   1398 N ND1 . HIS A 1 180 ? -11.184 -22.623 8.895  1.00 51.90  ? 206 HIS A ND1 1 
ATOM   1399 C CD2 . HIS A 1 180 ? -11.863 -21.064 10.262 1.00 50.22  ? 206 HIS A CD2 1 
ATOM   1400 C CE1 . HIS A 1 180 ? -11.196 -23.149 10.106 1.00 52.01  ? 206 HIS A CE1 1 
ATOM   1401 N NE2 . HIS A 1 180 ? -11.608 -22.224 10.956 1.00 57.84  ? 206 HIS A NE2 1 
ATOM   1402 N N   . SER A 1 181 ? -13.366 -18.616 5.695  1.00 62.39  ? 207 SER A N   1 
ATOM   1403 C CA  . SER A 1 181 ? -13.350 -17.736 4.522  1.00 58.35  ? 207 SER A CA  1 
ATOM   1404 C C   . SER A 1 181 ? -14.023 -16.401 4.789  1.00 63.87  ? 207 SER A C   1 
ATOM   1405 O O   . SER A 1 181 ? -13.803 -15.446 4.035  1.00 66.06  ? 207 SER A O   1 
ATOM   1406 C CB  . SER A 1 181 ? -14.047 -18.386 3.320  1.00 63.81  ? 207 SER A CB  1 
ATOM   1407 O OG  . SER A 1 181 ? -13.399 -19.575 2.932  1.00 69.53  ? 207 SER A OG  1 
ATOM   1408 N N   . MET A 1 182 ? -14.816 -16.300 5.849  1.00 67.04  ? 208 MET A N   1 
ATOM   1409 C CA  . MET A 1 182 ? -15.301 -15.000 6.284  1.00 67.68  ? 208 MET A CA  1 
ATOM   1410 C C   . MET A 1 182 ? -14.291 -14.288 7.163  1.00 63.28  ? 208 MET A C   1 
ATOM   1411 O O   . MET A 1 182 ? -14.583 -13.203 7.673  1.00 64.20  ? 208 MET A O   1 
ATOM   1412 C CB  . MET A 1 182 ? -16.623 -15.150 7.046  1.00 62.32  ? 208 MET A CB  1 
ATOM   1413 C CG  . MET A 1 182 ? -17.817 -15.531 6.171  1.00 63.51  ? 208 MET A CG  1 
ATOM   1414 S SD  . MET A 1 182 ? -19.077 -16.326 7.205  1.00 73.44  ? 208 MET A SD  1 
ATOM   1415 C CE  . MET A 1 182 ? -19.563 -14.951 8.248  1.00 62.38  ? 208 MET A CE  1 
ATOM   1416 N N   . GLY A 1 183 ? -13.106 -14.864 7.332  1.00 61.23  ? 209 GLY A N   1 
ATOM   1417 C CA  . GLY A 1 183 ? -12.104 -14.238 8.165  1.00 66.18  ? 209 GLY A CA  1 
ATOM   1418 C C   . GLY A 1 183 ? -12.227 -14.526 9.642  1.00 64.24  ? 209 GLY A C   1 
ATOM   1419 O O   . GLY A 1 183 ? -11.708 -13.751 10.453 1.00 67.61  ? 209 GLY A O   1 
ATOM   1420 N N   . LEU A 1 184 ? -12.877 -15.633 10.025 1.00 61.79  ? 210 LEU A N   1 
ATOM   1421 C CA  . LEU A 1 184 ? -13.135 -15.917 11.431 1.00 60.32  ? 210 LEU A CA  1 
ATOM   1422 C C   . LEU A 1 184 ? -12.628 -17.289 11.842 1.00 55.13  ? 210 LEU A C   1 
ATOM   1423 O O   . LEU A 1 184 ? -12.744 -18.266 11.101 1.00 56.23  ? 210 LEU A O   1 
ATOM   1424 C CB  . LEU A 1 184 ? -14.626 -15.837 11.736 1.00 61.02  ? 210 LEU A CB  1 
ATOM   1425 C CG  . LEU A 1 184 ? -15.155 -14.416 11.601 1.00 60.88  ? 210 LEU A CG  1 
ATOM   1426 C CD1 . LEU A 1 184 ? -16.566 -14.498 11.148 1.00 63.55  ? 210 LEU A CD1 1 
ATOM   1427 C CD2 . LEU A 1 184 ? -15.044 -13.663 12.930 1.00 68.88  ? 210 LEU A CD2 1 
ATOM   1428 N N   . ILE A 1 185 ? -12.162 -17.366 13.083 1.00 54.13  ? 211 ILE A N   1 
ATOM   1429 C CA  . ILE A 1 185 ? -11.814 -18.625 13.720 1.00 53.97  ? 211 ILE A CA  1 
ATOM   1430 C C   . ILE A 1 185 ? -12.938 -18.922 14.691 1.00 53.47  ? 211 ILE A C   1 
ATOM   1431 O O   . ILE A 1 185 ? -13.372 -18.019 15.415 1.00 61.05  ? 211 ILE A O   1 
ATOM   1432 C CB  . ILE A 1 185 ? -10.482 -18.522 14.476 1.00 60.23  ? 211 ILE A CB  1 
ATOM   1433 C CG1 . ILE A 1 185 ? -9.341  -18.085 13.541 1.00 65.96  ? 211 ILE A CG1 1 
ATOM   1434 C CG2 . ILE A 1 185 ? -10.206 -19.824 15.178 1.00 60.34  ? 211 ILE A CG2 1 
ATOM   1435 C CD1 . ILE A 1 185 ? -8.003  -17.909 14.277 1.00 72.00  ? 211 ILE A CD1 1 
ATOM   1436 N N   . HIS A 1 186 ? -13.419 -20.168 14.711 1.00 55.81  ? 212 HIS A N   1 
ATOM   1437 C CA  . HIS A 1 186 ? -14.607 -20.466 15.523 1.00 58.32  ? 212 HIS A CA  1 
ATOM   1438 C C   . HIS A 1 186 ? -14.265 -20.550 17.007 1.00 60.18  ? 212 HIS A C   1 
ATOM   1439 O O   . HIS A 1 186 ? -14.869 -19.848 17.835 1.00 58.79  ? 212 HIS A O   1 
ATOM   1440 C CB  . HIS A 1 186 ? -15.269 -21.768 15.055 1.00 51.16  ? 212 HIS A CB  1 
ATOM   1441 C CG  . HIS A 1 186 ? -16.651 -21.987 15.599 1.00 57.01  ? 212 HIS A CG  1 
ATOM   1442 N ND1 . HIS A 1 186 ? -16.907 -22.150 16.940 1.00 58.18  ? 212 HIS A ND1 1 
ATOM   1443 C CD2 . HIS A 1 186 ? -17.851 -22.091 14.975 1.00 61.96  ? 212 HIS A CD2 1 
ATOM   1444 C CE1 . HIS A 1 186 ? -18.203 -22.346 17.123 1.00 62.01  ? 212 HIS A CE1 1 
ATOM   1445 N NE2 . HIS A 1 186 ? -18.799 -22.317 15.947 1.00 58.33  ? 212 HIS A NE2 1 
ATOM   1446 N N   . ARG A 1 187 ? -13.319 -21.419 17.364 1.00 51.87  ? 213 ARG A N   1 
ATOM   1447 C CA  . ARG A 1 187 ? -12.772 -21.591 18.710 1.00 55.57  ? 213 ARG A CA  1 
ATOM   1448 C C   . ARG A 1 187 ? -13.686 -22.357 19.655 1.00 58.43  ? 213 ARG A C   1 
ATOM   1449 O O   . ARG A 1 187 ? -13.281 -22.617 20.789 1.00 56.35  ? 213 ARG A O   1 
ATOM   1450 C CB  . ARG A 1 187 ? -12.375 -20.270 19.388 1.00 59.05  ? 213 ARG A CB  1 
ATOM   1451 C CG  . ARG A 1 187 ? -11.473 -19.432 18.539 1.00 64.37  ? 213 ARG A CG  1 
ATOM   1452 C CD  . ARG A 1 187 ? -11.708 -17.994 18.892 1.00 66.08  ? 213 ARG A CD  1 
ATOM   1453 N NE  . ARG A 1 187 ? -10.601 -17.448 19.634 1.00 62.59  ? 213 ARG A NE  1 
ATOM   1454 C CZ  . ARG A 1 187 ? -10.691 -16.469 20.526 1.00 63.76  ? 213 ARG A CZ  1 
ATOM   1455 N NH1 . ARG A 1 187 ? -11.857 -15.893 20.831 1.00 55.05  ? 213 ARG A NH1 1 
ATOM   1456 N NH2 . ARG A 1 187 ? -9.584  -16.062 21.105 1.00 61.18  ? 213 ARG A NH2 1 
ATOM   1457 N N   . ASP A 1 188 ? -14.933 -22.629 19.302 1.00 57.32  ? 214 ASP A N   1 
ATOM   1458 C CA  . ASP A 1 188 ? -15.753 -23.415 20.215 1.00 59.90  ? 214 ASP A CA  1 
ATOM   1459 C C   . ASP A 1 188 ? -16.540 -24.455 19.430 1.00 60.62  ? 214 ASP A C   1 
ATOM   1460 O O   . ASP A 1 188 ? -17.742 -24.639 19.615 1.00 58.69  ? 214 ASP A O   1 
ATOM   1461 C CB  . ASP A 1 188 ? -16.657 -22.489 21.026 1.00 60.10  ? 214 ASP A CB  1 
ATOM   1462 C CG  . ASP A 1 188 ? -17.294 -23.183 22.209 1.00 67.49  ? 214 ASP A CG  1 
ATOM   1463 O OD1 . ASP A 1 188 ? -16.658 -24.122 22.760 1.00 60.35  ? 214 ASP A OD1 1 
ATOM   1464 O OD2 . ASP A 1 188 ? -18.447 -22.796 22.565 1.00 68.58  ? 214 ASP A OD2 1 
ATOM   1465 N N   . VAL A 1 189 ? -15.844 -25.189 18.572 1.00 61.08  ? 215 VAL A N   1 
ATOM   1466 C CA  . VAL A 1 189 ? -16.462 -26.246 17.782 1.00 59.18  ? 215 VAL A CA  1 
ATOM   1467 C C   . VAL A 1 189 ? -16.708 -27.445 18.679 1.00 62.09  ? 215 VAL A C   1 
ATOM   1468 O O   . VAL A 1 189 ? -15.772 -27.954 19.303 1.00 61.48  ? 215 VAL A O   1 
ATOM   1469 C CB  . VAL A 1 189 ? -15.565 -26.623 16.595 1.00 60.49  ? 215 VAL A CB  1 
ATOM   1470 C CG1 . VAL A 1 189 ? -16.043 -27.889 15.931 1.00 56.89  ? 215 VAL A CG1 1 
ATOM   1471 C CG2 . VAL A 1 189 ? -15.562 -25.510 15.623 1.00 62.71  ? 215 VAL A CG2 1 
ATOM   1472 N N   . LYS A 1 190 ? -17.954 -27.911 18.725 1.00 53.96  ? 216 LYS A N   1 
ATOM   1473 C CA  . LYS A 1 190 ? -18.312 -29.066 19.542 1.00 58.83  ? 216 LYS A CA  1 
ATOM   1474 C C   . LYS A 1 190 ? -19.718 -29.529 19.131 1.00 55.65  ? 216 LYS A C   1 
ATOM   1475 O O   . LYS A 1 190 ? -20.476 -28.743 18.568 1.00 52.23  ? 216 LYS A O   1 
ATOM   1476 C CB  . LYS A 1 190 ? -18.263 -28.725 21.046 1.00 56.45  ? 216 LYS A CB  1 
ATOM   1477 C CG  . LYS A 1 190 ? -19.099 -27.526 21.437 1.00 59.95  ? 216 LYS A CG  1 
ATOM   1478 C CD  . LYS A 1 190 ? -19.059 -27.244 22.966 1.00 60.16  ? 216 LYS A CD  1 
ATOM   1479 C CE  . LYS A 1 190 ? -19.807 -25.935 23.308 1.00 56.69  ? 216 LYS A CE  1 
ATOM   1480 N NZ  . LYS A 1 190 ? -19.959 -25.721 24.778 1.00 67.50  ? 216 LYS A NZ  1 
ATOM   1481 N N   . PRO A 1 191 ? -20.089 -30.784 19.441 1.00 55.92  ? 217 PRO A N   1 
ATOM   1482 C CA  . PRO A 1 191 ? -21.383 -31.310 18.963 1.00 59.24  ? 217 PRO A CA  1 
ATOM   1483 C C   . PRO A 1 191 ? -22.602 -30.534 19.434 1.00 58.66  ? 217 PRO A C   1 
ATOM   1484 O O   . PRO A 1 191 ? -23.615 -30.530 18.723 1.00 60.92  ? 217 PRO A O   1 
ATOM   1485 C CB  . PRO A 1 191 ? -21.399 -32.758 19.483 1.00 61.26  ? 217 PRO A CB  1 
ATOM   1486 C CG  . PRO A 1 191 ? -20.260 -32.872 20.438 1.00 62.96  ? 217 PRO A CG  1 
ATOM   1487 C CD  . PRO A 1 191 ? -19.259 -31.845 20.037 1.00 58.50  ? 217 PRO A CD  1 
ATOM   1488 N N   . ASP A 1 192 ? -22.527 -29.864 20.589 1.00 56.62  ? 218 ASP A N   1 
ATOM   1489 C CA  . ASP A 1 192 ? -23.615 -29.006 21.055 1.00 61.35  ? 218 ASP A CA  1 
ATOM   1490 C C   . ASP A 1 192 ? -23.871 -27.823 20.119 1.00 63.78  ? 218 ASP A C   1 
ATOM   1491 O O   . ASP A 1 192 ? -24.973 -27.256 20.135 1.00 62.74  ? 218 ASP A O   1 
ATOM   1492 C CB  . ASP A 1 192 ? -23.307 -28.473 22.459 1.00 61.34  ? 218 ASP A CB  1 
ATOM   1493 C CG  . ASP A 1 192 ? -22.688 -29.518 23.372 1.00 69.83  ? 218 ASP A CG  1 
ATOM   1494 O OD1 . ASP A 1 192 ? -21.572 -30.027 23.072 1.00 66.54  ? 218 ASP A OD1 1 
ATOM   1495 O OD2 . ASP A 1 192 ? -23.306 -29.804 24.422 1.00 75.03  ? 218 ASP A OD2 1 
ATOM   1496 N N   . ASN A 1 193 ? -22.841 -27.369 19.393 1.00 58.52  ? 219 ASN A N   1 
ATOM   1497 C CA  . ASN A 1 193 ? -22.897 -26.268 18.428 1.00 61.92  ? 219 ASN A CA  1 
ATOM   1498 C C   . ASN A 1 193 ? -23.250 -26.730 17.019 1.00 56.18  ? 219 ASN A C   1 
ATOM   1499 O O   . ASN A 1 193 ? -23.333 -25.894 16.109 1.00 54.47  ? 219 ASN A O   1 
ATOM   1500 C CB  . ASN A 1 193 ? -21.551 -25.510 18.368 1.00 55.91  ? 219 ASN A CB  1 
ATOM   1501 C CG  . ASN A 1 193 ? -21.245 -24.821 19.640 1.00 63.44  ? 219 ASN A CG  1 
ATOM   1502 O OD1 . ASN A 1 193 ? -21.996 -24.927 20.610 1.00 74.87  ? 219 ASN A OD1 1 
ATOM   1503 N ND2 . ASN A 1 193 ? -20.174 -24.080 19.658 1.00 64.29  ? 219 ASN A ND2 1 
ATOM   1504 N N   . MET A 1 194 ? -23.366 -28.034 16.798 1.00 51.63  ? 220 MET A N   1 
ATOM   1505 C CA  . MET A 1 194 ? -23.657 -28.575 15.483 1.00 56.16  ? 220 MET A CA  1 
ATOM   1506 C C   . MET A 1 194 ? -25.127 -29.010 15.457 1.00 55.83  ? 220 MET A C   1 
ATOM   1507 O O   . MET A 1 194 ? -25.506 -29.963 16.143 1.00 53.67  ? 220 MET A O   1 
ATOM   1508 C CB  . MET A 1 194 ? -22.727 -29.735 15.172 1.00 51.76  ? 220 MET A CB  1 
ATOM   1509 C CG  . MET A 1 194 ? -21.212 -29.368 15.228 1.00 55.82  ? 220 MET A CG  1 
ATOM   1510 S SD  . MET A 1 194 ? -20.362 -30.937 15.349 1.00 53.49  ? 220 MET A SD  1 
ATOM   1511 C CE  . MET A 1 194 ? -18.623 -30.406 15.623 1.00 55.56  ? 220 MET A CE  1 
ATOM   1512 N N   . LEU A 1 195 ? -25.937 -28.332 14.648 1.00 50.46  ? 221 LEU A N   1 
ATOM   1513 C CA  . LEU A 1 195 ? -27.380 -28.568 14.594 1.00 55.68  ? 221 LEU A CA  1 
ATOM   1514 C C   . LEU A 1 195 ? -27.754 -29.165 13.241 1.00 56.88  ? 221 LEU A C   1 
ATOM   1515 O O   . LEU A 1 195 ? -27.064 -28.937 12.245 1.00 54.13  ? 221 LEU A O   1 
ATOM   1516 C CB  . LEU A 1 195 ? -28.156 -27.261 14.814 1.00 46.34  ? 221 LEU A CB  1 
ATOM   1517 C CG  . LEU A 1 195 ? -28.058 -26.592 16.187 1.00 57.54  ? 221 LEU A CG  1 
ATOM   1518 C CD1 . LEU A 1 195 ? -28.591 -25.165 16.108 1.00 58.89  ? 221 LEU A CD1 1 
ATOM   1519 C CD2 . LEU A 1 195 ? -28.844 -27.377 17.193 1.00 60.30  ? 221 LEU A CD2 1 
ATOM   1520 N N   . LEU A 1 196 ? -28.856 -29.919 13.206 1.00 52.16  ? 222 LEU A N   1 
ATOM   1521 C CA  . LEU A 1 196 ? -29.315 -30.599 11.994 1.00 49.53  ? 222 LEU A CA  1 
ATOM   1522 C C   . LEU A 1 196 ? -30.643 -30.011 11.535 1.00 53.41  ? 222 LEU A C   1 
ATOM   1523 O O   . LEU A 1 196 ? -31.557 -29.802 12.359 1.00 47.84  ? 222 LEU A O   1 
ATOM   1524 C CB  . LEU A 1 196 ? -29.461 -32.100 12.250 1.00 52.47  ? 222 LEU A CB  1 
ATOM   1525 C CG  . LEU A 1 196 ? -28.175 -32.804 12.727 1.00 57.43  ? 222 LEU A CG  1 
ATOM   1526 C CD1 . LEU A 1 196 ? -28.480 -34.238 13.108 1.00 60.70  ? 222 LEU A CD1 1 
ATOM   1527 C CD2 . LEU A 1 196 ? -27.126 -32.787 11.643 1.00 48.98  ? 222 LEU A CD2 1 
ATOM   1528 N N   . ASP A 1 197 ? -30.758 -29.744 10.228 1.00 44.67  ? 223 ASP A N   1 
ATOM   1529 C CA  . ASP A 1 197 ? -31.977 -29.131 9.716  1.00 51.33  ? 223 ASP A CA  1 
ATOM   1530 C C   . ASP A 1 197 ? -33.032 -30.219 9.454  1.00 48.55  ? 223 ASP A C   1 
ATOM   1531 O O   . ASP A 1 197 ? -32.871 -31.384 9.838  1.00 49.93  ? 223 ASP A O   1 
ATOM   1532 C CB  . ASP A 1 197 ? -31.665 -28.236 8.514  1.00 44.51  ? 223 ASP A CB  1 
ATOM   1533 C CG  . ASP A 1 197 ? -31.036 -28.966 7.333  1.00 49.85  ? 223 ASP A CG  1 
ATOM   1534 O OD1 . ASP A 1 197 ? -31.031 -30.210 7.279  1.00 50.35  ? 223 ASP A OD1 1 
ATOM   1535 O OD2 . ASP A 1 197 ? -30.563 -28.253 6.409  1.00 51.37  ? 223 ASP A OD2 1 
ATOM   1536 N N   . LYS A 1 198 ? -34.163 -29.850 8.848  1.00 54.40  ? 224 LYS A N   1 
ATOM   1537 C CA  . LYS A 1 198 ? -35.196 -30.855 8.584  1.00 59.71  ? 224 LYS A CA  1 
ATOM   1538 C C   . LYS A 1 198 ? -34.693 -31.999 7.693  1.00 59.12  ? 224 LYS A C   1 
ATOM   1539 O O   . LYS A 1 198 ? -35.260 -33.100 7.716  1.00 55.35  ? 224 LYS A O   1 
ATOM   1540 C CB  . LYS A 1 198 ? -36.427 -30.194 7.944  1.00 51.34  ? 224 LYS A CB  1 
ATOM   1541 C CG  . LYS A 1 198 ? -36.153 -29.625 6.592  1.00 63.03  ? 224 LYS A CG  1 
ATOM   1542 C CD  . LYS A 1 198 ? -37.390 -28.967 6.041  1.00 69.66  ? 224 LYS A CD  1 
ATOM   1543 C CE  . LYS A 1 198 ? -38.583 -29.886 6.235  1.00 65.21  ? 224 LYS A CE  1 
ATOM   1544 N NZ  . LYS A 1 198 ? -39.596 -29.679 5.181  1.00 72.70  ? 224 LYS A NZ  1 
ATOM   1545 N N   . HIS A 1 199 ? -33.651 -31.777 6.898  1.00 54.45  ? 225 HIS A N   1 
ATOM   1546 C CA  . HIS A 1 199 ? -33.168 -32.833 6.022  1.00 50.50  ? 225 HIS A CA  1 
ATOM   1547 C C   . HIS A 1 199 ? -32.000 -33.598 6.609  1.00 53.81  ? 225 HIS A C   1 
ATOM   1548 O O   . HIS A 1 199 ? -31.473 -34.498 5.951  1.00 58.47  ? 225 HIS A O   1 
ATOM   1549 C CB  . HIS A 1 199 ? -32.784 -32.243 4.676  1.00 50.79  ? 225 HIS A CB  1 
ATOM   1550 C CG  . HIS A 1 199 ? -33.883 -31.459 4.043  1.00 56.39  ? 225 HIS A CG  1 
ATOM   1551 N ND1 . HIS A 1 199 ? -35.091 -32.030 3.692  1.00 52.67  ? 225 HIS A ND1 1 
ATOM   1552 C CD2 . HIS A 1 199 ? -33.962 -30.152 3.697  1.00 50.05  ? 225 HIS A CD2 1 
ATOM   1553 C CE1 . HIS A 1 199 ? -35.858 -31.108 3.138  1.00 58.07  ? 225 HIS A CE1 1 
ATOM   1554 N NE2 . HIS A 1 199 ? -35.199 -29.961 3.134  1.00 58.28  ? 225 HIS A NE2 1 
ATOM   1555 N N   . GLY A 1 200 ? -31.606 -33.291 7.838  1.00 52.60  ? 226 GLY A N   1 
ATOM   1556 C CA  . GLY A 1 200 ? -30.505 -33.994 8.462  1.00 57.10  ? 226 GLY A CA  1 
ATOM   1557 C C   . GLY A 1 200 ? -29.124 -33.466 8.117  1.00 55.45  ? 226 GLY A C   1 
ATOM   1558 O O   . GLY A 1 200 ? -28.136 -34.139 8.435  1.00 53.08  ? 226 GLY A O   1 
ATOM   1559 N N   . HIS A 1 201 ? -29.027 -32.282 7.507  1.00 47.24  ? 227 HIS A N   1 
ATOM   1560 C CA  . HIS A 1 201 ? -27.760 -31.619 7.241  1.00 55.39  ? 227 HIS A CA  1 
ATOM   1561 C C   . HIS A 1 201 ? -27.405 -30.593 8.312  1.00 60.81  ? 227 HIS A C   1 
ATOM   1562 O O   . HIS A 1 201 ? -28.269 -29.958 8.940  1.00 46.75  ? 227 HIS A O   1 
ATOM   1563 C CB  . HIS A 1 201 ? -27.778 -30.931 5.890  1.00 53.58  ? 227 HIS A CB  1 
ATOM   1564 C CG  . HIS A 1 201 ? -27.847 -31.888 4.750  1.00 55.91  ? 227 HIS A CG  1 
ATOM   1565 N ND1 . HIS A 1 201 ? -26.779 -32.681 4.389  1.00 51.71  ? 227 HIS A ND1 1 
ATOM   1566 C CD2 . HIS A 1 201 ? -28.870 -32.220 3.921  1.00 50.95  ? 227 HIS A CD2 1 
ATOM   1567 C CE1 . HIS A 1 201 ? -27.125 -33.432 3.355  1.00 61.21  ? 227 HIS A CE1 1 
ATOM   1568 N NE2 . HIS A 1 201 ? -28.391 -33.172 3.051  1.00 58.32  ? 227 HIS A NE2 1 
ATOM   1569 N N   . LEU A 1 202 ? -26.102 -30.374 8.438  1.00 48.42  ? 228 LEU A N   1 
ATOM   1570 C CA  . LEU A 1 202 ? -25.516 -29.681 9.563  1.00 48.49  ? 228 LEU A CA  1 
ATOM   1571 C C   . LEU A 1 202 ? -25.504 -28.178 9.338  1.00 48.16  ? 228 LEU A C   1 
ATOM   1572 O O   . LEU A 1 202 ? -25.439 -27.710 8.204  1.00 55.05  ? 228 LEU A O   1 
ATOM   1573 C CB  . LEU A 1 202 ? -24.087 -30.193 9.781  1.00 54.42  ? 228 LEU A CB  1 
ATOM   1574 C CG  . LEU A 1 202 ? -23.324 -29.487 10.886 1.00 60.15  ? 228 LEU A CG  1 
ATOM   1575 C CD1 . LEU A 1 202 ? -22.658 -30.538 11.736 1.00 68.27  ? 228 LEU A CD1 1 
ATOM   1576 C CD2 . LEU A 1 202 ? -22.293 -28.588 10.259 1.00 59.88  ? 228 LEU A CD2 1 
ATOM   1577 N N   . LYS A 1 203 ? -25.658 -27.419 10.424 1.00 50.64  ? 229 LYS A N   1 
ATOM   1578 C CA  . LYS A 1 203 ? -25.278 -26.008 10.447 1.00 56.79  ? 229 LYS A CA  1 
ATOM   1579 C C   . LYS A 1 203 ? -24.652 -25.700 11.801 1.00 56.06  ? 229 LYS A C   1 
ATOM   1580 O O   . LYS A 1 203 ? -24.919 -26.392 12.785 1.00 55.61  ? 229 LYS A O   1 
ATOM   1581 C CB  . LYS A 1 203 ? -26.436 -25.025 10.214 1.00 53.52  ? 229 LYS A CB  1 
ATOM   1582 C CG  . LYS A 1 203 ? -27.270 -25.246 9.008  1.00 52.24  ? 229 LYS A CG  1 
ATOM   1583 C CD  . LYS A 1 203 ? -28.410 -24.217 8.929  1.00 50.73  ? 229 LYS A CD  1 
ATOM   1584 C CE  . LYS A 1 203 ? -29.392 -24.566 7.783  1.00 50.47  ? 229 LYS A CE  1 
ATOM   1585 N NZ  . LYS A 1 203 ? -29.048 -23.933 6.481  1.00 53.05  ? 229 LYS A NZ  1 
ATOM   1586 N N   . LEU A 1 204 ? -23.774 -24.692 11.826 1.00 57.50  ? 230 LEU A N   1 
ATOM   1587 C CA  . LEU A 1 204 ? -23.131 -24.235 13.054 1.00 60.02  ? 230 LEU A CA  1 
ATOM   1588 C C   . LEU A 1 204 ? -23.944 -23.109 13.680 1.00 59.37  ? 230 LEU A C   1 
ATOM   1589 O O   . LEU A 1 204 ? -24.559 -22.305 12.970 1.00 54.67  ? 230 LEU A O   1 
ATOM   1590 C CB  . LEU A 1 204 ? -21.706 -23.764 12.766 1.00 53.23  ? 230 LEU A CB  1 
ATOM   1591 C CG  . LEU A 1 204 ? -20.787 -24.874 12.248 1.00 53.84  ? 230 LEU A CG  1 
ATOM   1592 C CD1 . LEU A 1 204 ? -19.334 -24.391 12.091 1.00 54.99  ? 230 LEU A CD1 1 
ATOM   1593 C CD2 . LEU A 1 204 ? -20.851 -26.099 13.125 1.00 55.94  ? 230 LEU A CD2 1 
ATOM   1594 N N   . ALA A 1 205 ? -23.926 -23.039 15.025 1.00 60.34  ? 231 ALA A N   1 
ATOM   1595 C CA  . ALA A 1 205 ? -24.884 -22.140 15.665 1.00 63.03  ? 231 ALA A CA  1 
ATOM   1596 C C   . ALA A 1 205 ? -24.316 -21.178 16.702 1.00 71.20  ? 231 ALA A C   1 
ATOM   1597 O O   . ALA A 1 205 ? -24.780 -20.033 16.785 1.00 80.93  ? 231 ALA A O   1 
ATOM   1598 C CB  . ALA A 1 205 ? -25.973 -22.964 16.349 1.00 62.23  ? 231 ALA A CB  1 
ATOM   1599 N N   . ASP A 1 206 ? -23.361 -21.587 17.506 1.00 63.43  ? 232 ASP A N   1 
ATOM   1600 C CA  . ASP A 1 206 ? -23.008 -20.781 18.680 1.00 66.94  ? 232 ASP A CA  1 
ATOM   1601 C C   . ASP A 1 206 ? -21.669 -20.137 18.350 1.00 66.80  ? 232 ASP A C   1 
ATOM   1602 O O   . ASP A 1 206 ? -20.611 -20.738 18.553 1.00 66.32  ? 232 ASP A O   1 
ATOM   1603 C CB  . ASP A 1 206 ? -22.951 -21.654 19.938 1.00 62.97  ? 232 ASP A CB  1 
ATOM   1604 C CG  . ASP A 1 206 ? -22.413 -20.919 21.184 1.00 63.85  ? 232 ASP A CG  1 
ATOM   1605 O OD1 . ASP A 1 206 ? -22.388 -19.672 21.240 1.00 64.08  ? 232 ASP A OD1 1 
ATOM   1606 O OD2 . ASP A 1 206 ? -21.994 -21.628 22.122 1.00 66.71  ? 232 ASP A OD2 1 
ATOM   1607 N N   . PHE A 1 207 ? -21.723 -18.887 17.905 1.00 61.61  ? 233 PHE A N   1 
ATOM   1608 C CA  . PHE A 1 207 ? -20.541 -18.161 17.472 1.00 63.68  ? 233 PHE A CA  1 
ATOM   1609 C C   . PHE A 1 207 ? -20.067 -17.156 18.517 1.00 60.59  ? 233 PHE A C   1 
ATOM   1610 O O   . PHE A 1 207 ? -19.427 -16.160 18.167 1.00 62.16  ? 233 PHE A O   1 
ATOM   1611 C CB  . PHE A 1 207 ? -20.841 -17.463 16.152 1.00 58.75  ? 233 PHE A CB  1 
ATOM   1612 C CG  . PHE A 1 207 ? -21.300 -18.397 15.080 1.00 65.53  ? 233 PHE A CG  1 
ATOM   1613 C CD1 . PHE A 1 207 ? -20.386 -19.148 14.365 1.00 60.57  ? 233 PHE A CD1 1 
ATOM   1614 C CD2 . PHE A 1 207 ? -22.652 -18.557 14.805 1.00 63.22  ? 233 PHE A CD2 1 
ATOM   1615 C CE1 . PHE A 1 207 ? -20.815 -20.027 13.368 1.00 62.21  ? 233 PHE A CE1 1 
ATOM   1616 C CE2 . PHE A 1 207 ? -23.078 -19.431 13.822 1.00 58.37  ? 233 PHE A CE2 1 
ATOM   1617 C CZ  . PHE A 1 207 ? -22.159 -20.168 13.103 1.00 59.29  ? 233 PHE A CZ  1 
ATOM   1618 N N   . GLY A 1 208 ? -20.363 -17.420 19.797 1.00 60.83  ? 234 GLY A N   1 
ATOM   1619 C CA  . GLY A 1 208 ? -19.988 -16.510 20.875 1.00 67.76  ? 234 GLY A CA  1 
ATOM   1620 C C   . GLY A 1 208 ? -18.488 -16.321 21.054 1.00 69.91  ? 234 GLY A C   1 
ATOM   1621 O O   . GLY A 1 208 ? -18.050 -15.295 21.575 1.00 68.61  ? 234 GLY A O   1 
ATOM   1622 N N   . THR A 1 209 ? -17.692 -17.317 20.673 1.00 68.79  ? 235 THR A N   1 
ATOM   1623 C CA  . THR A 1 209 ? -16.240 -17.295 20.808 1.00 67.51  ? 235 THR A CA  1 
ATOM   1624 C C   . THR A 1 209 ? -15.515 -16.771 19.567 1.00 70.37  ? 235 THR A C   1 
ATOM   1625 O O   . THR A 1 209 ? -14.285 -16.642 19.590 1.00 64.59  ? 235 THR A O   1 
ATOM   1626 C CB  . THR A 1 209 ? -15.753 -18.696 21.180 1.00 68.86  ? 235 THR A CB  1 
ATOM   1627 O OG1 . THR A 1 209 ? -16.691 -19.270 22.100 1.00 76.20  ? 235 THR A OG1 1 
ATOM   1628 C CG2 . THR A 1 209 ? -14.446 -18.621 21.891 1.00 68.31  ? 235 THR A CG2 1 
ATOM   1629 N N   . CYS A 1 210 ? -16.237 -16.444 18.496 1.00 67.72  ? 236 CYS A N   1 
ATOM   1630 C CA  . CYS A 1 210 ? -15.605 -16.216 17.202 1.00 62.39  ? 236 CYS A CA  1 
ATOM   1631 C C   . CYS A 1 210 ? -14.739 -14.960 17.226 1.00 68.53  ? 236 CYS A C   1 
ATOM   1632 O O   . CYS A 1 210 ? -15.083 -13.970 17.868 1.00 67.25  ? 236 CYS A O   1 
ATOM   1633 C CB  . CYS A 1 210 ? -16.675 -16.050 16.123 1.00 64.31  ? 236 CYS A CB  1 
ATOM   1634 S SG  . CYS A 1 210 ? -17.267 -17.593 15.402 1.00 74.57  ? 236 CYS A SG  1 
ATOM   1635 N N   . MET A 1 211 ? -13.604 -15.000 16.522 1.00 63.76  ? 237 MET A N   1 
ATOM   1636 C CA  . MET A 1 211 ? -12.714 -13.847 16.480 1.00 66.42  ? 237 MET A CA  1 
ATOM   1637 C C   . MET A 1 211 ? -12.229 -13.608 15.054 1.00 62.93  ? 237 MET A C   1 
ATOM   1638 O O   . MET A 1 211 ? -11.872 -14.555 14.349 1.00 61.21  ? 237 MET A O   1 
ATOM   1639 C CB  . MET A 1 211 ? -11.510 -14.035 17.416 1.00 60.07  ? 237 MET A CB  1 
ATOM   1640 C CG  . MET A 1 211 ? -10.870 -12.734 17.850 1.00 65.05  ? 237 MET A CG  1 
ATOM   1641 S SD  . MET A 1 211 ? -9.548  -13.044 19.052 1.00 84.78  ? 237 MET A SD  1 
ATOM   1642 C CE  . MET A 1 211 ? -8.474  -11.630 18.796 1.00 70.92  ? 237 MET A CE  1 
ATOM   1643 N N   . LYS A 1 212 ? -12.186 -12.340 14.638 1.00 66.42  ? 238 LYS A N   1 
ATOM   1644 C CA  . LYS A 1 212 ? -11.685 -12.017 13.306 1.00 71.95  ? 238 LYS A CA  1 
ATOM   1645 C C   . LYS A 1 212 ? -10.160 -12.115 13.271 1.00 68.98  ? 238 LYS A C   1 
ATOM   1646 O O   . LYS A 1 212 ? -9.472  -11.725 14.219 1.00 71.33  ? 238 LYS A O   1 
ATOM   1647 C CB  . LYS A 1 212 ? -12.168 -10.626 12.861 1.00 73.39  ? 238 LYS A CB  1 
ATOM   1648 C CG  . LYS A 1 212 ? -11.482 -9.439  13.544 1.00 88.32  ? 238 LYS A CG  1 
ATOM   1649 C CD  . LYS A 1 212 ? -11.864 -8.099  12.887 1.00 94.19  ? 238 LYS A CD  1 
ATOM   1650 C CE  . LYS A 1 212 ? -10.844 -6.991  13.202 1.00 91.15  ? 238 LYS A CE  1 
ATOM   1651 N NZ  . LYS A 1 212 ? -11.391 -5.631  12.896 1.00 91.60  ? 238 LYS A NZ  1 
ATOM   1652 N N   . MET A 1 213 ? -9.635  -12.642 12.170 1.00 76.18  ? 239 MET A N   1 
ATOM   1653 C CA  . MET A 1 213 ? -8.203  -12.861 12.026 1.00 78.47  ? 239 MET A CA  1 
ATOM   1654 C C   . MET A 1 213 ? -7.486  -11.588 11.584 1.00 81.91  ? 239 MET A C   1 
ATOM   1655 O O   . MET A 1 213 ? -8.088  -10.678 11.012 1.00 83.37  ? 239 MET A O   1 
ATOM   1656 C CB  . MET A 1 213 ? -7.922  -13.944 10.993 1.00 77.38  ? 239 MET A CB  1 
ATOM   1657 C CG  . MET A 1 213 ? -8.249  -15.331 11.420 1.00 73.36  ? 239 MET A CG  1 
ATOM   1658 S SD  . MET A 1 213 ? -8.459  -16.347 9.963  1.00 84.38  ? 239 MET A SD  1 
ATOM   1659 C CE  . MET A 1 213 ? -7.474  -17.707 10.431 1.00 64.70  ? 239 MET A CE  1 
ATOM   1660 N N   . ASP A 1 214 ? -6.171  -11.557 11.844 1.00 86.40  ? 240 ASP A N   1 
ATOM   1661 C CA  . ASP A 1 214 ? -5.229  -10.595 11.269 1.00 86.13  ? 240 ASP A CA  1 
ATOM   1662 C C   . ASP A 1 214 ? -5.219  -10.690 9.744  1.00 88.57  ? 240 ASP A C   1 
ATOM   1663 O O   . ASP A 1 214 ? -5.823  -11.578 9.134  1.00 79.70  ? 240 ASP A O   1 
ATOM   1664 C CB  . ASP A 1 214 ? -3.793  -10.873 11.743 1.00 83.79  ? 240 ASP A CB  1 
ATOM   1665 C CG  . ASP A 1 214 ? -3.445  -10.181 13.053 1.00 98.28  ? 240 ASP A CG  1 
ATOM   1666 O OD1 . ASP A 1 214 ? -3.874  -9.022  13.250 1.00 107.71 ? 240 ASP A OD1 1 
ATOM   1667 O OD2 . ASP A 1 214 ? -2.737  -10.798 13.891 1.00 99.83  ? 240 ASP A OD2 1 
ATOM   1668 N N   . GLU A 1 215 ? -4.456  -9.780  9.128  1.00 93.75  ? 241 GLU A N   1 
ATOM   1669 C CA  . GLU A 1 215 ? -4.079  -9.940  7.728  1.00 90.23  ? 241 GLU A CA  1 
ATOM   1670 C C   . GLU A 1 215 ? -3.142  -11.127 7.531  1.00 89.74  ? 241 GLU A C   1 
ATOM   1671 O O   . GLU A 1 215 ? -3.048  -11.646 6.413  1.00 93.35  ? 241 GLU A O   1 
ATOM   1672 C CB  . GLU A 1 215 ? -3.423  -8.656  7.191  1.00 96.42  ? 241 GLU A CB  1 
ATOM   1673 C CG  . GLU A 1 215 ? -4.175  -7.345  7.492  1.00 99.07  ? 241 GLU A CG  1 
ATOM   1674 C CD  . GLU A 1 215 ? -3.951  -6.815  8.921  1.00 106.49 ? 241 GLU A CD  1 
ATOM   1675 O OE1 . GLU A 1 215 ? -4.473  -5.720  9.241  1.00 113.59 ? 241 GLU A OE1 1 
ATOM   1676 O OE2 . GLU A 1 215 ? -3.262  -7.489  9.726  1.00 101.86 ? 241 GLU A OE2 1 
ATOM   1677 N N   . THR A 1 216 ? -2.447  -11.565 8.585  1.00 86.95  ? 242 THR A N   1 
ATOM   1678 C CA  . THR A 1 216 ? -1.637  -12.780 8.540  1.00 86.63  ? 242 THR A CA  1 
ATOM   1679 C C   . THR A 1 216 ? -2.465  -14.043 8.748  1.00 87.70  ? 242 THR A C   1 
ATOM   1680 O O   . THR A 1 216 ? -1.899  -15.146 8.721  1.00 82.81  ? 242 THR A O   1 
ATOM   1681 C CB  . THR A 1 216 ? -0.524  -12.742 9.605  1.00 90.06  ? 242 THR A CB  1 
ATOM   1682 O OG1 . THR A 1 216 ? -1.017  -12.170 10.828 1.00 93.64  ? 242 THR A OG1 1 
ATOM   1683 C CG2 . THR A 1 216 ? 0.668   -11.942 9.112  1.00 93.12  ? 242 THR A CG2 1 
ATOM   1684 N N   . GLY A 1 217 ? -3.776  -13.908 8.964  1.00 84.27  ? 243 GLY A N   1 
ATOM   1685 C CA  . GLY A 1 217 ? -4.604  -15.031 9.367  1.00 84.17  ? 243 GLY A CA  1 
ATOM   1686 C C   . GLY A 1 217 ? -4.421  -15.495 10.799 1.00 78.88  ? 243 GLY A C   1 
ATOM   1687 O O   . GLY A 1 217 ? -4.723  -16.653 11.107 1.00 76.22  ? 243 GLY A O   1 
ATOM   1688 N N   . MET A 1 218 ? -3.919  -14.638 11.682 1.00 80.02  ? 244 MET A N   1 
ATOM   1689 C CA  . MET A 1 218 ? -3.678  -14.982 13.077 1.00 78.59  ? 244 MET A CA  1 
ATOM   1690 C C   . MET A 1 218 ? -4.541  -14.109 13.970 1.00 74.13  ? 244 MET A C   1 
ATOM   1691 O O   . MET A 1 218 ? -5.097  -13.097 13.536 1.00 71.80  ? 244 MET A O   1 
ATOM   1692 C CB  . MET A 1 218 ? -2.203  -14.799 13.451 1.00 78.77  ? 244 MET A CB  1 
ATOM   1693 C CG  . MET A 1 218 ? -1.247  -15.521 12.537 1.00 81.85  ? 244 MET A CG  1 
ATOM   1694 S SD  . MET A 1 218 ? -1.004  -17.218 13.068 1.00 92.31  ? 244 MET A SD  1 
ATOM   1695 C CE  . MET A 1 218 ? 0.352   -17.045 14.225 1.00 73.82  ? 244 MET A CE  1 
ATOM   1696 N N   . VAL A 1 219 ? -4.650  -14.511 15.234 1.00 72.94  ? 245 VAL A N   1 
ATOM   1697 C CA  . VAL A 1 219 ? -5.275  -13.686 16.256 1.00 73.33  ? 245 VAL A CA  1 
ATOM   1698 C C   . VAL A 1 219 ? -4.315  -13.549 17.434 1.00 75.32  ? 245 VAL A C   1 
ATOM   1699 O O   . VAL A 1 219 ? -3.572  -14.485 17.753 1.00 74.19  ? 245 VAL A O   1 
ATOM   1700 C CB  . VAL A 1 219 ? -6.636  -14.269 16.697 1.00 71.72  ? 245 VAL A CB  1 
ATOM   1701 C CG1 . VAL A 1 219 ? -7.552  -14.446 15.489 1.00 69.60  ? 245 VAL A CG1 1 
ATOM   1702 C CG2 . VAL A 1 219 ? -6.453  -15.592 17.410 1.00 68.86  ? 245 VAL A CG2 1 
ATOM   1703 N N   . HIS A 1 220 ? -4.299  -12.360 18.042 1.00 80.59  ? 246 HIS A N   1 
ATOM   1704 C CA  . HIS A 1 220 ? -3.682  -12.138 19.349 1.00 83.46  ? 246 HIS A CA  1 
ATOM   1705 C C   . HIS A 1 220 ? -4.720  -12.424 20.426 1.00 77.97  ? 246 HIS A C   1 
ATOM   1706 O O   . HIS A 1 220 ? -5.730  -11.713 20.511 1.00 79.75  ? 246 HIS A O   1 
ATOM   1707 C CB  . HIS A 1 220 ? -3.206  -10.691 19.535 1.00 87.46  ? 246 HIS A CB  1 
ATOM   1708 C CG  . HIS A 1 220 ? -2.113  -10.252 18.614 1.00 93.64  ? 246 HIS A CG  1 
ATOM   1709 N ND1 . HIS A 1 220 ? -0.786  -10.241 18.992 1.00 98.04  ? 246 HIS A ND1 1 
ATOM   1710 C CD2 . HIS A 1 220 ? -2.152  -9.737  17.360 1.00 98.36  ? 246 HIS A CD2 1 
ATOM   1711 C CE1 . HIS A 1 220 ? -0.050  -9.775  17.997 1.00 95.53  ? 246 HIS A CE1 1 
ATOM   1712 N NE2 . HIS A 1 220 ? -0.855  -9.458  16.997 1.00 101.00 ? 246 HIS A NE2 1 
ATOM   1713 N N   . CYS A 1 221 ? -4.474  -13.425 21.268 1.00 75.75  ? 247 CYS A N   1 
ATOM   1714 C CA  . CYS A 1 221 ? -5.392  -13.629 22.382 1.00 73.12  ? 247 CYS A CA  1 
ATOM   1715 C C   . CYS A 1 221 ? -4.668  -14.267 23.550 1.00 71.80  ? 247 CYS A C   1 
ATOM   1716 O O   . CYS A 1 221 ? -3.870  -15.192 23.378 1.00 71.68  ? 247 CYS A O   1 
ATOM   1717 C CB  . CYS A 1 221 ? -6.615  -14.477 21.996 1.00 64.07  ? 247 CYS A CB  1 
ATOM   1718 S SG  . CYS A 1 221 ? -8.019  -14.302 23.146 1.00 72.98  ? 247 CYS A SG  1 
ATOM   1719 N N   . ASP A 1 222 ? -4.992  -13.772 24.743 1.00 76.51  ? 248 ASP A N   1 
ATOM   1720 C CA  . ASP A 1 222 ? -4.350  -14.147 25.997 1.00 73.73  ? 248 ASP A CA  1 
ATOM   1721 C C   . ASP A 1 222 ? -5.328  -14.807 26.953 1.00 72.54  ? 248 ASP A C   1 
ATOM   1722 O O   . ASP A 1 222 ? -5.049  -14.925 28.154 1.00 67.75  ? 248 ASP A O   1 
ATOM   1723 C CB  . ASP A 1 222 ? -3.726  -12.912 26.644 1.00 74.42  ? 248 ASP A CB  1 
ATOM   1724 C CG  . ASP A 1 222 ? -2.386  -12.555 26.027 1.00 90.29  ? 248 ASP A CG  1 
ATOM   1725 O OD1 . ASP A 1 222 ? -2.375  -11.927 24.937 1.00 95.12  ? 248 ASP A OD1 1 
ATOM   1726 O OD2 . ASP A 1 222 ? -1.348  -12.927 26.637 1.00 89.89  ? 248 ASP A OD2 1 
ATOM   1727 N N   . THR A 1 223 ? -6.471  -15.229 26.436 1.00 67.04  ? 249 THR A N   1 
ATOM   1728 C CA  . THR A 1 223 ? -7.507  -15.867 27.226 1.00 67.93  ? 249 THR A CA  1 
ATOM   1729 C C   . THR A 1 223 ? -7.829  -17.218 26.608 1.00 66.99  ? 249 THR A C   1 
ATOM   1730 O O   . THR A 1 223 ? -8.127  -17.304 25.408 1.00 66.76  ? 249 THR A O   1 
ATOM   1731 C CB  . THR A 1 223 ? -8.765  -14.992 27.285 1.00 71.34  ? 249 THR A CB  1 
ATOM   1732 O OG1 . THR A 1 223 ? -8.407  -13.693 27.773 1.00 74.72  ? 249 THR A OG1 1 
ATOM   1733 C CG2 . THR A 1 223 ? -9.826  -15.618 28.202 1.00 65.68  ? 249 THR A CG2 1 
ATOM   1734 N N   . ALA A 1 224 ? -7.733  -18.271 27.412 1.00 61.47  ? 250 ALA A N   1 
ATOM   1735 C CA  . ALA A 1 224 ? -8.245  -19.556 26.972 1.00 65.74  ? 250 ALA A CA  1 
ATOM   1736 C C   . ALA A 1 224 ? -9.760  -19.445 26.841 1.00 66.90  ? 250 ALA A C   1 
ATOM   1737 O O   . ALA A 1 224 ? -10.418 -18.891 27.729 1.00 73.13  ? 250 ALA A O   1 
ATOM   1738 C CB  . ALA A 1 224 ? -7.859  -20.651 27.968 1.00 60.17  ? 250 ALA A CB  1 
ATOM   1739 N N   . VAL A 1 225 ? -10.306 -19.927 25.720 1.00 61.41  ? 251 VAL A N   1 
ATOM   1740 C CA  . VAL A 1 225 ? -11.732 -19.823 25.418 1.00 65.01  ? 251 VAL A CA  1 
ATOM   1741 C C   . VAL A 1 225 ? -12.235 -21.185 24.965 1.00 64.12  ? 251 VAL A C   1 
ATOM   1742 O O   . VAL A 1 225 ? -11.460 -22.085 24.637 1.00 69.52  ? 251 VAL A O   1 
ATOM   1743 C CB  . VAL A 1 225 ? -12.041 -18.764 24.341 1.00 68.18  ? 251 VAL A CB  1 
ATOM   1744 C CG1 . VAL A 1 225 ? -11.923 -17.350 24.909 1.00 63.98  ? 251 VAL A CG1 1 
ATOM   1745 C CG2 . VAL A 1 225 ? -11.121 -18.963 23.128 1.00 65.21  ? 251 VAL A CG2 1 
ATOM   1746 N N   . GLY A 1 226 ? -13.556 -21.329 24.958 1.00 69.39  ? 252 GLY A N   1 
ATOM   1747 C CA  . GLY A 1 226 ? -14.196 -22.523 24.432 1.00 62.63  ? 252 GLY A CA  1 
ATOM   1748 C C   . GLY A 1 226 ? -14.634 -23.476 25.530 1.00 63.13  ? 252 GLY A C   1 
ATOM   1749 O O   . GLY A 1 226 ? -14.917 -23.057 26.656 1.00 67.85  ? 252 GLY A O   1 
ATOM   1750 N N   . THR A 1 227 ? -14.639 -24.767 25.225 1.00 61.87  ? 253 THR A N   1 
ATOM   1751 C CA  . THR A 1 227 ? -15.133 -25.830 26.088 1.00 63.14  ? 253 THR A CA  1 
ATOM   1752 C C   . THR A 1 227 ? -14.015 -26.785 26.499 1.00 66.23  ? 253 THR A C   1 
ATOM   1753 O O   . THR A 1 227 ? -13.185 -27.147 25.655 1.00 63.66  ? 253 THR A O   1 
ATOM   1754 C CB  . THR A 1 227 ? -16.254 -26.588 25.367 1.00 63.14  ? 253 THR A CB  1 
ATOM   1755 O OG1 . THR A 1 227 ? -17.346 -25.678 25.170 1.00 64.18  ? 253 THR A OG1 1 
ATOM   1756 C CG2 . THR A 1 227 ? -16.727 -27.775 26.186 1.00 60.33  ? 253 THR A CG2 1 
ATOM   1757 N N   . PRO A 1 228 ? -13.955 -27.210 27.776 1.00 64.40  ? 254 PRO A N   1 
ATOM   1758 C CA  . PRO A 1 228 ? -12.731 -27.892 28.250 1.00 65.55  ? 254 PRO A CA  1 
ATOM   1759 C C   . PRO A 1 228 ? -12.376 -29.145 27.467 1.00 65.87  ? 254 PRO A C   1 
ATOM   1760 O O   . PRO A 1 228 ? -11.193 -29.337 27.167 1.00 61.55  ? 254 PRO A O   1 
ATOM   1761 C CB  . PRO A 1 228 ? -13.073 -28.222 29.709 1.00 68.09  ? 254 PRO A CB  1 
ATOM   1762 C CG  . PRO A 1 228 ? -13.987 -27.098 30.129 1.00 68.69  ? 254 PRO A CG  1 
ATOM   1763 C CD  . PRO A 1 228 ? -14.788 -26.725 28.896 1.00 64.21  ? 254 PRO A CD  1 
ATOM   1764 N N   . ASP A 1 229 ? -13.353 -30.005 27.130 1.00 60.02  ? 255 ASP A N   1 
ATOM   1765 C CA  . ASP A 1 229 ? -13.056 -31.244 26.407 1.00 62.42  ? 255 ASP A CA  1 
ATOM   1766 C C   . ASP A 1 229 ? -12.470 -30.996 25.014 1.00 56.60  ? 255 ASP A C   1 
ATOM   1767 O O   . ASP A 1 229 ? -11.795 -31.873 24.460 1.00 56.07  ? 255 ASP A O   1 
ATOM   1768 C CB  . ASP A 1 229 ? -14.313 -32.104 26.283 1.00 61.40  ? 255 ASP A CB  1 
ATOM   1769 C CG  . ASP A 1 229 ? -14.612 -32.883 27.557 1.00 70.80  ? 255 ASP A CG  1 
ATOM   1770 O OD1 . ASP A 1 229 ? -13.812 -33.778 27.892 1.00 71.68  ? 255 ASP A OD1 1 
ATOM   1771 O OD2 . ASP A 1 229 ? -15.636 -32.607 28.223 1.00 72.82  ? 255 ASP A OD2 1 
ATOM   1772 N N   . TYR A 1 230 ? -12.779 -29.851 24.404 1.00 54.76  ? 256 TYR A N   1 
ATOM   1773 C CA  . TYR A 1 230 ? -12.450 -29.583 23.005 1.00 59.40  ? 256 TYR A CA  1 
ATOM   1774 C C   . TYR A 1 230 ? -11.368 -28.534 22.804 1.00 56.27  ? 256 TYR A C   1 
ATOM   1775 O O   . TYR A 1 230 ? -10.990 -28.274 21.653 1.00 54.06  ? 256 TYR A O   1 
ATOM   1776 C CB  . TYR A 1 230 ? -13.712 -29.148 22.231 1.00 50.86  ? 256 TYR A CB  1 
ATOM   1777 C CG  . TYR A 1 230 ? -14.718 -30.274 22.149 1.00 60.31  ? 256 TYR A CG  1 
ATOM   1778 C CD1 . TYR A 1 230 ? -15.593 -30.515 23.188 1.00 64.81  ? 256 TYR A CD1 1 
ATOM   1779 C CD2 . TYR A 1 230 ? -14.740 -31.135 21.066 1.00 64.93  ? 256 TYR A CD2 1 
ATOM   1780 C CE1 . TYR A 1 230 ? -16.477 -31.568 23.139 1.00 67.24  ? 256 TYR A CE1 1 
ATOM   1781 C CE2 . TYR A 1 230 ? -15.622 -32.191 21.013 1.00 65.38  ? 256 TYR A CE2 1 
ATOM   1782 C CZ  . TYR A 1 230 ? -16.477 -32.399 22.058 1.00 67.15  ? 256 TYR A CZ  1 
ATOM   1783 O OH  . TYR A 1 230 ? -17.369 -33.435 22.010 1.00 85.44  ? 256 TYR A OH  1 
ATOM   1784 N N   . ILE A 1 231 ? -10.845 -27.925 23.857 1.00 54.20  ? 257 ILE A N   1 
ATOM   1785 C CA  . ILE A 1 231 ? -9.934  -26.812 23.609 1.00 58.01  ? 257 ILE A CA  1 
ATOM   1786 C C   . ILE A 1 231 ? -8.573  -27.366 23.187 1.00 53.77  ? 257 ILE A C   1 
ATOM   1787 O O   . ILE A 1 231 ? -8.114  -28.410 23.678 1.00 52.24  ? 257 ILE A O   1 
ATOM   1788 C CB  . ILE A 1 231 ? -9.847  -25.901 24.849 1.00 55.01  ? 257 ILE A CB  1 
ATOM   1789 C CG1 . ILE A 1 231 ? -8.913  -24.711 24.609 1.00 57.65  ? 257 ILE A CG1 1 
ATOM   1790 C CG2 . ILE A 1 231 ? -9.426  -26.666 26.086 1.00 58.79  ? 257 ILE A CG2 1 
ATOM   1791 C CD1 . ILE A 1 231 ? -8.923  -23.739 25.791 1.00 61.87  ? 257 ILE A CD1 1 
ATOM   1792 N N   . SER A 1 232 ? -7.933  -26.666 22.258 1.00 54.89  ? 258 SER A N   1 
ATOM   1793 C CA  . SER A 1 232 ? -6.680  -27.116 21.681 1.00 53.68  ? 258 SER A CA  1 
ATOM   1794 C C   . SER A 1 232 ? -5.516  -26.702 22.582 1.00 57.27  ? 258 SER A C   1 
ATOM   1795 O O   . SER A 1 232 ? -5.636  -25.754 23.370 1.00 53.75  ? 258 SER A O   1 
ATOM   1796 C CB  . SER A 1 232 ? -6.497  -26.500 20.307 1.00 46.04  ? 258 SER A CB  1 
ATOM   1797 O OG  . SER A 1 232 ? -6.319  -25.093 20.423 1.00 52.10  ? 258 SER A OG  1 
ATOM   1798 N N   . PRO A 1 233 ? -4.366  -27.380 22.477 1.00 60.97  ? 259 PRO A N   1 
ATOM   1799 C CA  . PRO A 1 233 ? -3.224  -26.985 23.326 1.00 57.09  ? 259 PRO A CA  1 
ATOM   1800 C C   . PRO A 1 233 ? -2.855  -25.522 23.196 1.00 55.61  ? 259 PRO A C   1 
ATOM   1801 O O   . PRO A 1 233 ? -2.684  -24.842 24.218 1.00 59.11  ? 259 PRO A O   1 
ATOM   1802 C CB  . PRO A 1 233 ? -2.100  -27.905 22.840 1.00 57.98  ? 259 PRO A CB  1 
ATOM   1803 C CG  . PRO A 1 233 ? -2.837  -29.172 22.419 1.00 61.59  ? 259 PRO A CG  1 
ATOM   1804 C CD  . PRO A 1 233 ? -4.139  -28.678 21.814 1.00 58.83  ? 259 PRO A CD  1 
ATOM   1805 N N   . GLU A 1 234 ? -2.831  -24.987 21.974 1.00 55.40  ? 260 GLU A N   1 
ATOM   1806 C CA  . GLU A 1 234 ? -2.350  -23.621 21.794 1.00 57.52  ? 260 GLU A CA  1 
ATOM   1807 C C   . GLU A 1 234 ? -3.315  -22.584 22.384 1.00 63.13  ? 260 GLU A C   1 
ATOM   1808 O O   . GLU A 1 234 ? -2.866  -21.537 22.883 1.00 57.70  ? 260 GLU A O   1 
ATOM   1809 C CB  . GLU A 1 234 ? -2.069  -23.362 20.312 1.00 58.95  ? 260 GLU A CB  1 
ATOM   1810 C CG  . GLU A 1 234 ? -3.310  -23.329 19.406 1.00 63.48  ? 260 GLU A CG  1 
ATOM   1811 C CD  . GLU A 1 234 ? -3.613  -24.673 18.731 1.00 56.07  ? 260 GLU A CD  1 
ATOM   1812 O OE1 . GLU A 1 234 ? -3.335  -25.747 19.304 1.00 56.69  ? 260 GLU A OE1 1 
ATOM   1813 O OE2 . GLU A 1 234 ? -4.173  -24.658 17.620 1.00 57.92  ? 260 GLU A OE2 1 
ATOM   1814 N N   . VAL A 1 235 ? -4.632  -22.847 22.364 1.00 59.47  ? 261 VAL A N   1 
ATOM   1815 C CA  . VAL A 1 235 ? -5.569  -21.909 22.980 1.00 53.87  ? 261 VAL A CA  1 
ATOM   1816 C C   . VAL A 1 235 ? -5.497  -22.031 24.497 1.00 54.85  ? 261 VAL A C   1 
ATOM   1817 O O   . VAL A 1 235 ? -5.533  -21.035 25.222 1.00 54.85  ? 261 VAL A O   1 
ATOM   1818 C CB  . VAL A 1 235 ? -7.004  -22.134 22.447 1.00 55.22  ? 261 VAL A CB  1 
ATOM   1819 C CG1 . VAL A 1 235 ? -8.042  -21.335 23.277 1.00 53.06  ? 261 VAL A CG1 1 
ATOM   1820 C CG2 . VAL A 1 235 ? -7.079  -21.760 20.979 1.00 49.06  ? 261 VAL A CG2 1 
ATOM   1821 N N   . LEU A 1 236 ? -5.377  -23.255 24.997 1.00 55.51  ? 262 LEU A N   1 
ATOM   1822 C CA  . LEU A 1 236 ? -5.137  -23.456 26.417 1.00 57.05  ? 262 LEU A CA  1 
ATOM   1823 C C   . LEU A 1 236 ? -3.867  -22.729 26.871 1.00 62.75  ? 262 LEU A C   1 
ATOM   1824 O O   . LEU A 1 236 ? -3.883  -21.980 27.855 1.00 63.51  ? 262 LEU A O   1 
ATOM   1825 C CB  . LEU A 1 236 ? -5.031  -24.951 26.686 1.00 57.79  ? 262 LEU A CB  1 
ATOM   1826 C CG  . LEU A 1 236 ? -5.068  -25.356 28.144 1.00 67.67  ? 262 LEU A CG  1 
ATOM   1827 C CD1 . LEU A 1 236 ? -6.383  -24.868 28.733 1.00 65.18  ? 262 LEU A CD1 1 
ATOM   1828 C CD2 . LEU A 1 236 ? -4.928  -26.873 28.254 1.00 65.20  ? 262 LEU A CD2 1 
ATOM   1829 N N   . LYS A 1 237 ? -2.764  -22.909 26.130 1.00 62.22  ? 263 LYS A N   1 
ATOM   1830 C CA  . LYS A 1 237 ? -1.469  -22.303 26.466 1.00 61.69  ? 263 LYS A CA  1 
ATOM   1831 C C   . LYS A 1 237 ? -1.490  -20.788 26.356 1.00 62.03  ? 263 LYS A C   1 
ATOM   1832 O O   . LYS A 1 237 ? -0.667  -20.117 26.982 1.00 57.74  ? 263 LYS A O   1 
ATOM   1833 C CB  . LYS A 1 237 ? -0.367  -22.840 25.546 1.00 61.06  ? 263 LYS A CB  1 
ATOM   1834 C CG  . LYS A 1 237 ? 0.119   -24.263 25.835 1.00 72.01  ? 263 LYS A CG  1 
ATOM   1835 C CD  . LYS A 1 237 ? 1.518   -24.489 25.213 1.00 79.37  ? 263 LYS A CD  1 
ATOM   1836 C CE  . LYS A 1 237 ? 2.432   -23.250 25.404 1.00 85.86  ? 263 LYS A CE  1 
ATOM   1837 N NZ  . LYS A 1 237 ? 3.394   -22.960 24.277 1.00 87.19  ? 263 LYS A NZ  1 
ATOM   1838 N N   . SER A 1 238 ? -2.419  -20.228 25.583 1.00 61.93  ? 264 SER A N   1 
ATOM   1839 C CA  . SER A 1 238 ? -2.433  -18.789 25.386 1.00 63.39  ? 264 SER A CA  1 
ATOM   1840 C C   . SER A 1 238 ? -2.885  -18.032 26.626 1.00 62.32  ? 264 SER A C   1 
ATOM   1841 O O   . SER A 1 238 ? -2.719  -16.806 26.674 1.00 63.96  ? 264 SER A O   1 
ATOM   1842 C CB  . SER A 1 238 ? -3.386  -18.439 24.248 1.00 62.46  ? 264 SER A CB  1 
ATOM   1843 O OG  . SER A 1 238 ? -4.732  -18.416 24.746 1.00 58.25  ? 264 SER A OG  1 
ATOM   1844 N N   . GLN A 1 239 ? -3.371  -18.737 27.647 1.00 58.41  ? 265 GLN A N   1 
ATOM   1845 C CA  . GLN A 1 239 ? -3.928  -18.093 28.831 1.00 66.11  ? 265 GLN A CA  1 
ATOM   1846 C C   . GLN A 1 239 ? -2.846  -17.336 29.608 1.00 69.89  ? 265 GLN A C   1 
ATOM   1847 O O   . GLN A 1 239 ? -1.914  -17.939 30.147 1.00 61.89  ? 265 GLN A O   1 
ATOM   1848 C CB  . GLN A 1 239 ? -4.609  -19.142 29.719 1.00 62.42  ? 265 GLN A CB  1 
ATOM   1849 C CG  . GLN A 1 239 ? -5.162  -18.582 31.022 1.00 64.24  ? 265 GLN A CG  1 
ATOM   1850 C CD  . GLN A 1 239 ? -6.291  -17.594 30.786 1.00 65.03  ? 265 GLN A CD  1 
ATOM   1851 O OE1 . GLN A 1 239 ? -7.288  -17.914 30.129 1.00 67.99  ? 265 GLN A OE1 1 
ATOM   1852 N NE2 . GLN A 1 239 ? -6.139  -16.388 31.308 1.00 62.80  ? 265 GLN A NE2 1 
ATOM   1853 N N   . GLY A 1 240 ? -2.955  -16.006 29.625 1.00 74.20  ? 266 GLY A N   1 
ATOM   1854 C CA  . GLY A 1 240 ? -1.950  -15.131 30.200 1.00 76.31  ? 266 GLY A CA  1 
ATOM   1855 C C   . GLY A 1 240 ? -0.593  -15.113 29.517 1.00 84.85  ? 266 GLY A C   1 
ATOM   1856 O O   . GLY A 1 240 ? 0.385   -14.721 30.157 1.00 89.91  ? 266 GLY A O   1 
ATOM   1857 N N   . GLY A 1 241 ? -0.492  -15.497 28.234 1.00 80.02  ? 267 GLY A N   1 
ATOM   1858 C CA  . GLY A 1 241 ? 0.828   -15.707 27.647 1.00 84.31  ? 267 GLY A CA  1 
ATOM   1859 C C   . GLY A 1 241 ? 1.090   -15.279 26.209 1.00 87.70  ? 267 GLY A C   1 
ATOM   1860 O O   . GLY A 1 241 ? 1.921   -15.893 25.526 1.00 89.31  ? 267 GLY A O   1 
ATOM   1861 N N   . ASP A 1 242 ? 0.428   -14.205 25.761 1.00 87.02  ? 268 ASP A N   1 
ATOM   1862 C CA  . ASP A 1 242 ? 0.458   -13.699 24.382 1.00 90.89  ? 268 ASP A CA  1 
ATOM   1863 C C   . ASP A 1 242 ? 0.307   -14.790 23.323 1.00 83.76  ? 268 ASP A C   1 
ATOM   1864 O O   . ASP A 1 242 ? 1.248   -15.097 22.579 1.00 76.36  ? 268 ASP A O   1 
ATOM   1865 C CB  . ASP A 1 242 ? 1.725   -12.879 24.107 1.00 90.18  ? 268 ASP A CB  1 
ATOM   1866 C CG  . ASP A 1 242 ? 1.462   -11.722 23.133 1.00 96.20  ? 268 ASP A CG  1 
ATOM   1867 O OD1 . ASP A 1 242 ? 0.280   -11.515 22.753 1.00 99.39  ? 268 ASP A OD1 1 
ATOM   1868 O OD2 . ASP A 1 242 ? 2.428   -11.022 22.749 1.00 97.95  ? 268 ASP A OD2 1 
ATOM   1869 N N   . GLY A 1 243 ? -0.895  -15.354 23.242 1.00 79.39  ? 269 GLY A N   1 
ATOM   1870 C CA  . GLY A 1 243 ? -1.186  -16.321 22.203 1.00 75.98  ? 269 GLY A CA  1 
ATOM   1871 C C   . GLY A 1 243 ? -1.211  -15.669 20.830 1.00 74.42  ? 269 GLY A C   1 
ATOM   1872 O O   . GLY A 1 243 ? -1.703  -14.554 20.646 1.00 72.78  ? 269 GLY A O   1 
ATOM   1873 N N   . PHE A 1 244 ? -0.641  -16.376 19.864 1.00 74.13  ? 270 PHE A N   1 
ATOM   1874 C CA  . PHE A 1 244 ? -0.644  -15.963 18.469 1.00 74.60  ? 270 PHE A CA  1 
ATOM   1875 C C   . PHE A 1 244 ? -0.854  -17.255 17.688 1.00 71.80  ? 270 PHE A C   1 
ATOM   1876 O O   . PHE A 1 244 ? 0.051   -18.095 17.608 1.00 73.18  ? 270 PHE A O   1 
ATOM   1877 C CB  . PHE A 1 244 ? 0.657   -15.250 18.102 1.00 78.92  ? 270 PHE A CB  1 
ATOM   1878 C CG  . PHE A 1 244 ? 0.495   -14.203 17.035 1.00 82.57  ? 270 PHE A CG  1 
ATOM   1879 C CD1 . PHE A 1 244 ? -0.602  -13.351 17.034 1.00 85.30  ? 270 PHE A CD1 1 
ATOM   1880 C CD2 . PHE A 1 244 ? 1.431   -14.073 16.026 1.00 85.25  ? 270 PHE A CD2 1 
ATOM   1881 C CE1 . PHE A 1 244 ? -0.764  -12.394 16.033 1.00 90.48  ? 270 PHE A CE1 1 
ATOM   1882 C CE2 . PHE A 1 244 ? 1.282   -13.113 15.019 1.00 92.38  ? 270 PHE A CE2 1 
ATOM   1883 C CZ  . PHE A 1 244 ? 0.183   -12.269 15.026 1.00 93.61  ? 270 PHE A CZ  1 
ATOM   1884 N N   . TYR A 1 245 ? -2.061  -17.437 17.153 1.00 69.20  ? 271 TYR A N   1 
ATOM   1885 C CA  . TYR A 1 245 ? -2.404  -18.705 16.523 1.00 68.00  ? 271 TYR A CA  1 
ATOM   1886 C C   . TYR A 1 245 ? -3.385  -18.480 15.379 1.00 68.21  ? 271 TYR A C   1 
ATOM   1887 O O   . TYR A 1 245 ? -3.947  -17.394 15.211 1.00 66.34  ? 271 TYR A O   1 
ATOM   1888 C CB  . TYR A 1 245 ? -2.967  -19.707 17.536 1.00 61.05  ? 271 TYR A CB  1 
ATOM   1889 C CG  . TYR A 1 245 ? -4.127  -19.205 18.367 1.00 66.00  ? 271 TYR A CG  1 
ATOM   1890 C CD1 . TYR A 1 245 ? -5.426  -19.251 17.876 1.00 59.18  ? 271 TYR A CD1 1 
ATOM   1891 C CD2 . TYR A 1 245 ? -3.931  -18.719 19.665 1.00 63.86  ? 271 TYR A CD2 1 
ATOM   1892 C CE1 . TYR A 1 245 ? -6.504  -18.810 18.630 1.00 62.86  ? 271 TYR A CE1 1 
ATOM   1893 C CE2 . TYR A 1 245 ? -5.013  -18.279 20.442 1.00 64.00  ? 271 TYR A CE2 1 
ATOM   1894 C CZ  . TYR A 1 245 ? -6.306  -18.331 19.914 1.00 65.36  ? 271 TYR A CZ  1 
ATOM   1895 O OH  . TYR A 1 245 ? -7.401  -17.896 20.652 1.00 58.94  ? 271 TYR A OH  1 
ATOM   1896 N N   . GLY A 1 246 ? -3.585  -19.535 14.592 1.00 62.97  ? 272 GLY A N   1 
ATOM   1897 C CA  . GLY A 1 246 ? -4.440  -19.437 13.430 1.00 70.02  ? 272 GLY A CA  1 
ATOM   1898 C C   . GLY A 1 246 ? -5.661  -20.342 13.456 1.00 66.69  ? 272 GLY A C   1 
ATOM   1899 O O   . GLY A 1 246 ? -6.007  -20.933 14.490 1.00 61.63  ? 272 GLY A O   1 
ATOM   1900 N N   . ARG A 1 247 ? -6.320  -20.440 12.300 1.00 61.62  ? 273 ARG A N   1 
ATOM   1901 C CA  . ARG A 1 247 ? -7.561  -21.193 12.160 1.00 61.49  ? 273 ARG A CA  1 
ATOM   1902 C C   . ARG A 1 247 ? -7.389  -22.663 12.467 1.00 63.61  ? 273 ARG A C   1 
ATOM   1903 O O   . ARG A 1 247 ? -8.394  -23.363 12.638 1.00 59.44  ? 273 ARG A O   1 
ATOM   1904 C CB  . ARG A 1 247 ? -8.121  -21.042 10.735 1.00 62.47  ? 273 ARG A CB  1 
ATOM   1905 C CG  . ARG A 1 247 ? -7.432  -21.925 9.688  1.00 63.36  ? 273 ARG A CG  1 
ATOM   1906 C CD  . ARG A 1 247 ? -7.644  -21.361 8.282  1.00 67.21  ? 273 ARG A CD  1 
ATOM   1907 N NE  . ARG A 1 247 ? -7.188  -19.973 8.201  1.00 66.93  ? 273 ARG A NE  1 
ATOM   1908 C CZ  . ARG A 1 247 ? -7.471  -19.141 7.207  1.00 70.34  ? 273 ARG A CZ  1 
ATOM   1909 N NH1 . ARG A 1 247 ? -8.225  -19.540 6.181  1.00 68.91  ? 273 ARG A NH1 1 
ATOM   1910 N NH2 . ARG A 1 247 ? -6.994  -17.902 7.245  1.00 69.09  ? 273 ARG A NH2 1 
ATOM   1911 N N   . GLU A 1 248 ? -6.152  -23.163 12.523 1.00 60.34  ? 274 GLU A N   1 
ATOM   1912 C CA  . GLU A 1 248 ? -6.013  -24.606 12.651 1.00 56.95  ? 274 GLU A CA  1 
ATOM   1913 C C   . GLU A 1 248 ? -6.413  -25.127 14.028 1.00 50.77  ? 274 GLU A C   1 
ATOM   1914 O O   . GLU A 1 248 ? -6.575  -26.349 14.179 1.00 52.58  ? 274 GLU A O   1 
ATOM   1915 C CB  . GLU A 1 248 ? -4.577  -25.042 12.297 1.00 64.90  ? 274 GLU A CB  1 
ATOM   1916 C CG  . GLU A 1 248 ? -3.466  -24.355 13.094 1.00 61.22  ? 274 GLU A CG  1 
ATOM   1917 C CD  . GLU A 1 248 ? -3.006  -23.028 12.519 1.00 67.00  ? 274 GLU A CD  1 
ATOM   1918 O OE1 . GLU A 1 248 ? -3.608  -22.534 11.540 1.00 71.94  ? 274 GLU A OE1 1 
ATOM   1919 O OE2 . GLU A 1 248 ? -2.025  -22.466 13.069 1.00 83.45  ? 274 GLU A OE2 1 
ATOM   1920 N N   . CYS A 1 249 ? -6.571  -24.257 15.035 1.00 51.32  ? 275 CYS A N   1 
ATOM   1921 C CA  . CYS A 1 249 ? -7.184  -24.678 16.297 1.00 46.89  ? 275 CYS A CA  1 
ATOM   1922 C C   . CYS A 1 249 ? -8.554  -25.323 16.087 1.00 54.09  ? 275 CYS A C   1 
ATOM   1923 O O   . CYS A 1 249 ? -8.928  -26.242 16.837 1.00 51.71  ? 275 CYS A O   1 
ATOM   1924 C CB  . CYS A 1 249 ? -7.287  -23.512 17.289 1.00 55.88  ? 275 CYS A CB  1 
ATOM   1925 S SG  . CYS A 1 249 ? -8.322  -22.105 16.830 1.00 63.54  ? 275 CYS A SG  1 
ATOM   1926 N N   . ASP A 1 250 ? -9.337  -24.823 15.116 1.00 51.13  ? 276 ASP A N   1 
ATOM   1927 C CA  . ASP A 1 250 ? -10.638 -25.441 14.837 1.00 56.53  ? 276 ASP A CA  1 
ATOM   1928 C C   . ASP A 1 250 ? -10.481 -26.888 14.375 1.00 54.91  ? 276 ASP A C   1 
ATOM   1929 O O   . ASP A 1 250 ? -11.344 -27.729 14.668 1.00 51.23  ? 276 ASP A O   1 
ATOM   1930 C CB  . ASP A 1 250 ? -11.399 -24.630 13.781 1.00 49.14  ? 276 ASP A CB  1 
ATOM   1931 C CG  . ASP A 1 250 ? -11.890 -23.292 14.314 1.00 52.69  ? 276 ASP A CG  1 
ATOM   1932 O OD1 . ASP A 1 250 ? -12.047 -23.188 15.542 1.00 53.22  ? 276 ASP A OD1 1 
ATOM   1933 O OD2 . ASP A 1 250 ? -12.126 -22.353 13.515 1.00 53.69  ? 276 ASP A OD2 1 
ATOM   1934 N N   . TRP A 1 251 ? -9.385  -27.213 13.664 1.00 46.82  ? 277 TRP A N   1 
ATOM   1935 C CA  . TRP A 1 251 ? -9.236  -28.584 13.197 1.00 46.03  ? 277 TRP A CA  1 
ATOM   1936 C C   . TRP A 1 251 ? -8.960  -29.543 14.337 1.00 49.33  ? 277 TRP A C   1 
ATOM   1937 O O   . TRP A 1 251 ? -9.338  -30.720 14.242 1.00 52.13  ? 277 TRP A O   1 
ATOM   1938 C CB  . TRP A 1 251 ? -8.140  -28.703 12.111 1.00 54.78  ? 277 TRP A CB  1 
ATOM   1939 C CG  . TRP A 1 251 ? -8.307  -27.769 10.955 1.00 53.52  ? 277 TRP A CG  1 
ATOM   1940 C CD1 . TRP A 1 251 ? -7.355  -26.945 10.434 1.00 54.78  ? 277 TRP A CD1 1 
ATOM   1941 C CD2 . TRP A 1 251 ? -9.502  -27.554 10.166 1.00 49.79  ? 277 TRP A CD2 1 
ATOM   1942 N NE1 . TRP A 1 251 ? -7.873  -26.227 9.386  1.00 56.94  ? 277 TRP A NE1 1 
ATOM   1943 C CE2 . TRP A 1 251 ? -9.195  -26.571 9.212  1.00 50.84  ? 277 TRP A CE2 1 
ATOM   1944 C CE3 . TRP A 1 251 ? -10.798 -28.092 10.193 1.00 54.48  ? 277 TRP A CE3 1 
ATOM   1945 C CZ2 . TRP A 1 251 ? -10.127 -26.121 8.252  1.00 53.98  ? 277 TRP A CZ2 1 
ATOM   1946 C CZ3 . TRP A 1 251 ? -11.741 -27.624 9.247  1.00 51.39  ? 277 TRP A CZ3 1 
ATOM   1947 C CH2 . TRP A 1 251 ? -11.396 -26.654 8.299  1.00 56.94  ? 277 TRP A CH2 1 
ATOM   1948 N N   . TRP A 1 252 ? -8.300  -29.078 15.410 1.00 53.08  ? 278 TRP A N   1 
ATOM   1949 C CA  . TRP A 1 252 ? -8.136  -29.911 16.597 1.00 52.60  ? 278 TRP A CA  1 
ATOM   1950 C C   . TRP A 1 252 ? -9.495  -30.341 17.159 1.00 53.94  ? 278 TRP A C   1 
ATOM   1951 O O   . TRP A 1 252 ? -9.683  -31.495 17.565 1.00 50.80  ? 278 TRP A O   1 
ATOM   1952 C CB  . TRP A 1 252 ? -7.328  -29.157 17.665 1.00 49.52  ? 278 TRP A CB  1 
ATOM   1953 C CG  . TRP A 1 252 ? -7.379  -29.816 19.044 1.00 51.33  ? 278 TRP A CG  1 
ATOM   1954 C CD1 . TRP A 1 252 ? -8.432  -29.780 19.952 1.00 53.88  ? 278 TRP A CD1 1 
ATOM   1955 C CD2 . TRP A 1 252 ? -6.337  -30.577 19.677 1.00 57.98  ? 278 TRP A CD2 1 
ATOM   1956 N NE1 . TRP A 1 252 ? -8.110  -30.499 21.072 1.00 56.26  ? 278 TRP A NE1 1 
ATOM   1957 C CE2 . TRP A 1 252 ? -6.832  -30.990 20.940 1.00 56.23  ? 278 TRP A CE2 1 
ATOM   1958 C CE3 . TRP A 1 252 ? -5.030  -30.957 19.297 1.00 49.91  ? 278 TRP A CE3 1 
ATOM   1959 C CZ2 . TRP A 1 252 ? -6.072  -31.768 21.825 1.00 57.19  ? 278 TRP A CZ2 1 
ATOM   1960 C CZ3 . TRP A 1 252 ? -4.284  -31.729 20.170 1.00 55.08  ? 278 TRP A CZ3 1 
ATOM   1961 C CH2 . TRP A 1 252 ? -4.809  -32.131 21.422 1.00 61.19  ? 278 TRP A CH2 1 
ATOM   1962 N N   . SER A 1 253 ? -10.433 -29.402 17.262 1.00 51.79  ? 279 SER A N   1 
ATOM   1963 C CA  . SER A 1 253 ? -11.759 -29.773 17.757 1.00 59.17  ? 279 SER A CA  1 
ATOM   1964 C C   . SER A 1 253 ? -12.437 -30.768 16.832 1.00 49.64  ? 279 SER A C   1 
ATOM   1965 O O   . SER A 1 253 ? -13.236 -31.584 17.288 1.00 53.73  ? 279 SER A O   1 
ATOM   1966 C CB  . SER A 1 253 ? -12.638 -28.539 17.959 1.00 58.10  ? 279 SER A CB  1 
ATOM   1967 O OG  . SER A 1 253 ? -11.985 -27.622 18.809 1.00 62.81  ? 279 SER A OG  1 
ATOM   1968 N N   . VAL A 1 254 ? -12.116 -30.745 15.542 1.00 50.30  ? 280 VAL A N   1 
ATOM   1969 C CA  . VAL A 1 254 ? -12.721 -31.737 14.661 1.00 53.12  ? 280 VAL A CA  1 
ATOM   1970 C C   . VAL A 1 254 ? -12.229 -33.127 15.029 1.00 53.62  ? 280 VAL A C   1 
ATOM   1971 O O   . VAL A 1 254 ? -13.014 -34.082 15.073 1.00 52.87  ? 280 VAL A O   1 
ATOM   1972 C CB  . VAL A 1 254 ? -12.458 -31.389 13.189 1.00 50.63  ? 280 VAL A CB  1 
ATOM   1973 C CG1 . VAL A 1 254 ? -13.043 -32.453 12.271 1.00 51.32  ? 280 VAL A CG1 1 
ATOM   1974 C CG2 . VAL A 1 254 ? -13.043 -30.081 12.869 1.00 49.05  ? 280 VAL A CG2 1 
ATOM   1975 N N   . GLY A 1 255 ? -10.936 -33.261 15.364 1.00 51.28  ? 281 GLY A N   1 
ATOM   1976 C CA  . GLY A 1 255 ? -10.447 -34.550 15.830 1.00 46.64  ? 281 GLY A CA  1 
ATOM   1977 C C   . GLY A 1 255 ? -11.111 -35.028 17.113 1.00 49.83  ? 281 GLY A C   1 
ATOM   1978 O O   . GLY A 1 255 ? -11.382 -36.220 17.276 1.00 55.03  ? 281 GLY A O   1 
ATOM   1979 N N   . VAL A 1 256 ? -11.331 -34.126 18.069 1.00 52.81  ? 282 VAL A N   1 
ATOM   1980 C CA  . VAL A 1 256 ? -12.029 -34.537 19.294 1.00 53.62  ? 282 VAL A CA  1 
ATOM   1981 C C   . VAL A 1 256 ? -13.434 -35.041 18.954 1.00 55.29  ? 282 VAL A C   1 
ATOM   1982 O O   . VAL A 1 256 ? -13.853 -36.119 19.401 1.00 56.17  ? 282 VAL A O   1 
ATOM   1983 C CB  . VAL A 1 256 ? -12.084 -33.377 20.303 1.00 57.98  ? 282 VAL A CB  1 
ATOM   1984 C CG1 . VAL A 1 256 ? -12.782 -33.823 21.610 1.00 51.78  ? 282 VAL A CG1 1 
ATOM   1985 C CG2 . VAL A 1 256 ? -10.679 -32.798 20.549 1.00 59.74  ? 282 VAL A CG2 1 
ATOM   1986 N N   . PHE A 1 257 ? -14.159 -34.281 18.120 1.00 51.37  ? 283 PHE A N   1 
ATOM   1987 C CA  . PHE A 1 257 ? -15.490 -34.686 17.650 1.00 53.75  ? 283 PHE A CA  1 
ATOM   1988 C C   . PHE A 1 257 ? -15.455 -36.076 17.031 1.00 57.46  ? 283 PHE A C   1 
ATOM   1989 O O   . PHE A 1 257 ? -16.252 -36.947 17.395 1.00 54.53  ? 283 PHE A O   1 
ATOM   1990 C CB  . PHE A 1 257 ? -16.013 -33.648 16.645 1.00 46.05  ? 283 PHE A CB  1 
ATOM   1991 C CG  . PHE A 1 257 ? -17.298 -34.041 15.936 1.00 56.69  ? 283 PHE A CG  1 
ATOM   1992 C CD1 . PHE A 1 257 ? -18.401 -34.498 16.645 1.00 54.80  ? 283 PHE A CD1 1 
ATOM   1993 C CD2 . PHE A 1 257 ? -17.409 -33.897 14.559 1.00 57.71  ? 283 PHE A CD2 1 
ATOM   1994 C CE1 . PHE A 1 257 ? -19.591 -34.833 15.987 1.00 59.93  ? 283 PHE A CE1 1 
ATOM   1995 C CE2 . PHE A 1 257 ? -18.602 -34.225 13.878 1.00 59.29  ? 283 PHE A CE2 1 
ATOM   1996 C CZ  . PHE A 1 257 ? -19.692 -34.692 14.597 1.00 60.08  ? 283 PHE A CZ  1 
ATOM   1997 N N   . LEU A 1 258 ? -14.516 -36.317 16.103 1.00 54.97  ? 284 LEU A N   1 
ATOM   1998 C CA  . LEU A 1 258 ? -14.515 -37.604 15.419 1.00 50.60  ? 284 LEU A CA  1 
ATOM   1999 C C   . LEU A 1 258 ? -14.175 -38.726 16.381 1.00 56.33  ? 284 LEU A C   1 
ATOM   2000 O O   . LEU A 1 258 ? -14.741 -39.824 16.286 1.00 63.64  ? 284 LEU A O   1 
ATOM   2001 C CB  . LEU A 1 258 ? -13.567 -37.584 14.219 1.00 58.89  ? 284 LEU A CB  1 
ATOM   2002 C CG  . LEU A 1 258 ? -13.413 -38.873 13.409 1.00 57.85  ? 284 LEU A CG  1 
ATOM   2003 C CD1 . LEU A 1 258 ? -14.755 -39.402 12.912 1.00 57.72  ? 284 LEU A CD1 1 
ATOM   2004 C CD2 . LEU A 1 258 ? -12.477 -38.614 12.219 1.00 56.63  ? 284 LEU A CD2 1 
ATOM   2005 N N   . TYR A 1 259 ? -13.245 -38.486 17.306 1.00 57.44  ? 285 TYR A N   1 
ATOM   2006 C CA  . TYR A 1 259 ? -12.984 -39.480 18.348 1.00 60.29  ? 285 TYR A CA  1 
ATOM   2007 C C   . TYR A 1 259 ? -14.259 -39.788 19.132 1.00 61.50  ? 285 TYR A C   1 
ATOM   2008 O O   . TYR A 1 259 ? -14.614 -40.955 19.329 1.00 61.41  ? 285 TYR A O   1 
ATOM   2009 C CB  . TYR A 1 259 ? -11.879 -38.996 19.281 1.00 57.00  ? 285 TYR A CB  1 
ATOM   2010 C CG  . TYR A 1 259 ? -11.467 -39.977 20.367 1.00 64.51  ? 285 TYR A CG  1 
ATOM   2011 C CD1 . TYR A 1 259 ? -12.227 -40.135 21.512 1.00 61.57  ? 285 TYR A CD1 1 
ATOM   2012 C CD2 . TYR A 1 259 ? -10.273 -40.699 20.271 1.00 69.12  ? 285 TYR A CD2 1 
ATOM   2013 C CE1 . TYR A 1 259 ? -11.855 -41.020 22.510 1.00 67.40  ? 285 TYR A CE1 1 
ATOM   2014 C CE2 . TYR A 1 259 ? -9.883  -41.577 21.274 1.00 70.32  ? 285 TYR A CE2 1 
ATOM   2015 C CZ  . TYR A 1 259 ? -10.682 -41.734 22.385 1.00 71.25  ? 285 TYR A CZ  1 
ATOM   2016 O OH  . TYR A 1 259 ? -10.308 -42.598 23.379 1.00 80.12  ? 285 TYR A OH  1 
ATOM   2017 N N   . GLU A 1 260 ? -14.957 -38.750 19.598 1.00 52.30  ? 286 GLU A N   1 
ATOM   2018 C CA  . GLU A 1 260 ? -16.152 -39.001 20.397 1.00 66.63  ? 286 GLU A CA  1 
ATOM   2019 C C   . GLU A 1 260 ? -17.187 -39.799 19.618 1.00 57.82  ? 286 GLU A C   1 
ATOM   2020 O O   . GLU A 1 260 ? -17.764 -40.746 20.153 1.00 61.54  ? 286 GLU A O   1 
ATOM   2021 C CB  . GLU A 1 260 ? -16.768 -37.694 20.891 1.00 63.15  ? 286 GLU A CB  1 
ATOM   2022 C CG  . GLU A 1 260 ? -17.716 -37.955 22.057 1.00 74.43  ? 286 GLU A CG  1 
ATOM   2023 C CD  . GLU A 1 260 ? -18.460 -36.720 22.541 1.00 75.22  ? 286 GLU A CD  1 
ATOM   2024 O OE1 . GLU A 1 260 ? -18.026 -35.587 22.237 1.00 74.66  ? 286 GLU A OE1 1 
ATOM   2025 O OE2 . GLU A 1 260 ? -19.487 -36.893 23.233 1.00 81.36  ? 286 GLU A OE2 1 
ATOM   2026 N N   . MET A 1 261 ? -17.370 -39.486 18.332 1.00 58.09  ? 287 MET A N   1 
ATOM   2027 C CA  . MET A 1 261 ? -18.348 -40.196 17.511 1.00 62.42  ? 287 MET A CA  1 
ATOM   2028 C C   . MET A 1 261 ? -18.023 -41.681 17.399 1.00 69.49  ? 287 MET A C   1 
ATOM   2029 O O   . MET A 1 261 ? -18.927 -42.527 17.458 1.00 66.31  ? 287 MET A O   1 
ATOM   2030 C CB  . MET A 1 261 ? -18.407 -39.582 16.115 1.00 61.47  ? 287 MET A CB  1 
ATOM   2031 C CG  . MET A 1 261 ? -19.592 -38.689 15.852 1.00 63.35  ? 287 MET A CG  1 
ATOM   2032 S SD  . MET A 1 261 ? -19.730 -38.386 14.078 1.00 70.33  ? 287 MET A SD  1 
ATOM   2033 C CE  . MET A 1 261 ? -18.110 -37.645 13.707 1.00 60.12  ? 287 MET A CE  1 
ATOM   2034 N N   . LEU A 1 262 ? -16.741 -42.020 17.199 1.00 66.81  ? 288 LEU A N   1 
ATOM   2035 C CA  . LEU A 1 262 ? -16.367 -43.412 16.971 1.00 64.96  ? 288 LEU A CA  1 
ATOM   2036 C C   . LEU A 1 262 ? -16.100 -44.177 18.256 1.00 68.42  ? 288 LEU A C   1 
ATOM   2037 O O   . LEU A 1 262 ? -16.269 -45.404 18.283 1.00 68.82  ? 288 LEU A O   1 
ATOM   2038 C CB  . LEU A 1 262 ? -15.130 -43.499 16.063 1.00 65.26  ? 288 LEU A CB  1 
ATOM   2039 C CG  . LEU A 1 262 ? -15.347 -42.915 14.676 1.00 64.05  ? 288 LEU A CG  1 
ATOM   2040 C CD1 . LEU A 1 262 ? -14.103 -43.045 13.778 1.00 66.39  ? 288 LEU A CD1 1 
ATOM   2041 C CD2 . LEU A 1 262 ? -16.542 -43.605 14.044 1.00 66.46  ? 288 LEU A CD2 1 
ATOM   2042 N N   . VAL A 1 263 ? -15.697 -43.502 19.329 1.00 66.71  ? 289 VAL A N   1 
ATOM   2043 C CA  . VAL A 1 263 ? -15.313 -44.195 20.546 1.00 64.54  ? 289 VAL A CA  1 
ATOM   2044 C C   . VAL A 1 263 ? -16.443 -44.213 21.564 1.00 70.11  ? 289 VAL A C   1 
ATOM   2045 O O   . VAL A 1 263 ? -16.647 -45.214 22.247 1.00 73.00  ? 289 VAL A O   1 
ATOM   2046 C CB  . VAL A 1 263 ? -14.027 -43.573 21.131 1.00 69.52  ? 289 VAL A CB  1 
ATOM   2047 C CG1 . VAL A 1 263 ? -13.676 -44.207 22.481 1.00 71.42  ? 289 VAL A CG1 1 
ATOM   2048 C CG2 . VAL A 1 263 ? -12.887 -43.752 20.162 1.00 69.40  ? 289 VAL A CG2 1 
ATOM   2049 N N   . GLY A 1 264 ? -17.203 -43.133 21.655 1.00 70.95  ? 290 GLY A N   1 
ATOM   2050 C CA  . GLY A 1 264 ? -18.223 -42.975 22.666 1.00 68.99  ? 290 GLY A CA  1 
ATOM   2051 C C   . GLY A 1 264 ? -17.841 -42.020 23.771 1.00 73.54  ? 290 GLY A C   1 
ATOM   2052 O O   . GLY A 1 264 ? -18.729 -41.567 24.500 1.00 76.05  ? 290 GLY A O   1 
ATOM   2053 N N   . ASP A 1 265 ? -16.565 -41.648 23.884 1.00 71.91  ? 291 ASP A N   1 
ATOM   2054 C CA  . ASP A 1 265 ? -16.129 -40.714 24.914 1.00 74.07  ? 291 ASP A CA  1 
ATOM   2055 C C   . ASP A 1 265 ? -15.189 -39.683 24.317 1.00 71.36  ? 291 ASP A C   1 
ATOM   2056 O O   . ASP A 1 265 ? -14.643 -39.872 23.231 1.00 69.62  ? 291 ASP A O   1 
ATOM   2057 C CB  . ASP A 1 265 ? -15.421 -41.430 26.055 1.00 78.44  ? 291 ASP A CB  1 
ATOM   2058 C CG  . ASP A 1 265 ? -16.347 -42.347 26.820 1.00 86.06  ? 291 ASP A CG  1 
ATOM   2059 O OD1 . ASP A 1 265 ? -17.148 -41.841 27.643 1.00 89.38  ? 291 ASP A OD1 1 
ATOM   2060 O OD2 . ASP A 1 265 ? -16.270 -43.574 26.594 1.00 88.31  ? 291 ASP A OD2 1 
ATOM   2061 N N   . THR A 1 266 ? -15.025 -38.567 25.029 1.00 67.38  ? 292 THR A N   1 
ATOM   2062 C CA  . THR A 1 266 ? -14.034 -37.616 24.550 1.00 70.15  ? 292 THR A CA  1 
ATOM   2063 C C   . THR A 1 266 ? -12.629 -38.106 24.894 1.00 68.63  ? 292 THR A C   1 
ATOM   2064 O O   . THR A 1 266 ? -12.425 -38.765 25.913 1.00 71.04  ? 292 THR A O   1 
ATOM   2065 C CB  . THR A 1 266 ? -14.286 -36.234 25.132 1.00 62.84  ? 292 THR A CB  1 
ATOM   2066 O OG1 . THR A 1 266 ? -14.240 -36.307 26.561 1.00 74.72  ? 292 THR A OG1 1 
ATOM   2067 C CG2 . THR A 1 266 ? -15.667 -35.732 24.691 1.00 67.76  ? 292 THR A CG2 1 
ATOM   2068 N N   . PRO A 1 267 ? -11.645 -37.820 24.041 1.00 65.96  ? 293 PRO A N   1 
ATOM   2069 C CA  . PRO A 1 267 ? -10.324 -38.437 24.204 1.00 67.62  ? 293 PRO A CA  1 
ATOM   2070 C C   . PRO A 1 267 ? -9.535  -37.916 25.388 1.00 66.46  ? 293 PRO A C   1 
ATOM   2071 O O   . PRO A 1 267 ? -8.500  -38.501 25.715 1.00 70.09  ? 293 PRO A O   1 
ATOM   2072 C CB  . PRO A 1 267 ? -9.628  -38.093 22.887 1.00 61.30  ? 293 PRO A CB  1 
ATOM   2073 C CG  . PRO A 1 267 ? -10.267 -36.806 22.498 1.00 61.54  ? 293 PRO A CG  1 
ATOM   2074 C CD  . PRO A 1 267 ? -11.711 -37.010 22.820 1.00 61.57  ? 293 PRO A CD  1 
ATOM   2075 N N   . PHE A 1 268 ? -9.957  -36.834 26.026 1.00 66.60  ? 294 PHE A N   1 
ATOM   2076 C CA  . PHE A 1 268 ? -9.235  -36.303 27.178 1.00 71.02  ? 294 PHE A CA  1 
ATOM   2077 C C   . PHE A 1 268 ? -10.156 -36.173 28.362 1.00 70.51  ? 294 PHE A C   1 
ATOM   2078 O O   . PHE A 1 268 ? -10.073 -35.207 29.129 1.00 66.62  ? 294 PHE A O   1 
ATOM   2079 C CB  . PHE A 1 268 ? -8.574  -34.966 26.859 1.00 58.04  ? 294 PHE A CB  1 
ATOM   2080 C CG  . PHE A 1 268 ? -7.747  -35.015 25.634 1.00 65.46  ? 294 PHE A CG  1 
ATOM   2081 C CD1 . PHE A 1 268 ? -6.535  -35.692 25.632 1.00 67.70  ? 294 PHE A CD1 1 
ATOM   2082 C CD2 . PHE A 1 268 ? -8.185  -34.417 24.467 1.00 60.38  ? 294 PHE A CD2 1 
ATOM   2083 C CE1 . PHE A 1 268 ? -5.756  -35.743 24.487 1.00 61.32  ? 294 PHE A CE1 1 
ATOM   2084 C CE2 . PHE A 1 268 ? -7.422  -34.473 23.316 1.00 60.36  ? 294 PHE A CE2 1 
ATOM   2085 C CZ  . PHE A 1 268 ? -6.212  -35.143 23.324 1.00 65.25  ? 294 PHE A CZ  1 
ATOM   2086 N N   . TYR A 1 269 ? -11.068 -37.133 28.512 1.00 73.76  ? 295 TYR A N   1 
ATOM   2087 C CA  . TYR A 1 269 ? -11.941 -37.118 29.673 1.00 75.15  ? 295 TYR A CA  1 
ATOM   2088 C C   . TYR A 1 269 ? -11.115 -37.265 30.943 1.00 78.55  ? 295 TYR A C   1 
ATOM   2089 O O   . TYR A 1 269 ? -10.230 -38.122 31.041 1.00 82.01  ? 295 TYR A O   1 
ATOM   2090 C CB  . TYR A 1 269 ? -12.974 -38.246 29.603 1.00 75.53  ? 295 TYR A CB  1 
ATOM   2091 C CG  . TYR A 1 269 ? -13.881 -38.239 30.813 1.00 83.44  ? 295 TYR A CG  1 
ATOM   2092 C CD1 . TYR A 1 269 ? -13.506 -38.873 32.009 1.00 82.79  ? 295 TYR A CD1 1 
ATOM   2093 C CD2 . TYR A 1 269 ? -15.095 -37.559 30.782 1.00 82.68  ? 295 TYR A CD2 1 
ATOM   2094 C CE1 . TYR A 1 269 ? -14.323 -38.837 33.129 1.00 86.61  ? 295 TYR A CE1 1 
ATOM   2095 C CE2 . TYR A 1 269 ? -15.926 -37.524 31.890 1.00 87.32  ? 295 TYR A CE2 1 
ATOM   2096 C CZ  . TYR A 1 269 ? -15.540 -38.165 33.063 1.00 90.97  ? 295 TYR A CZ  1 
ATOM   2097 O OH  . TYR A 1 269 ? -16.372 -38.125 34.167 1.00 87.29  ? 295 TYR A OH  1 
ATOM   2098 N N   . ALA A 1 270 ? -11.451 -36.455 31.941 1.00 76.63  ? 296 ALA A N   1 
ATOM   2099 C CA  . ALA A 1 270 ? -10.910 -36.612 33.277 1.00 80.34  ? 296 ALA A CA  1 
ATOM   2100 C C   . ALA A 1 270 ? -12.005 -36.262 34.272 1.00 81.51  ? 296 ALA A C   1 
ATOM   2101 O O   . ALA A 1 270 ? -13.030 -35.661 33.922 1.00 77.25  ? 296 ALA A O   1 
ATOM   2102 C CB  . ALA A 1 270 ? -9.651  -35.745 33.490 1.00 72.10  ? 296 ALA A CB  1 
ATOM   2103 N N   . ASP A 1 271 ? -11.771 -36.648 35.529 1.00 84.90  ? 297 ASP A N   1 
ATOM   2104 C CA  . ASP A 1 271 ? -12.752 -36.405 36.579 1.00 85.68  ? 297 ASP A CA  1 
ATOM   2105 C C   . ASP A 1 271 ? -12.846 -34.929 36.922 1.00 82.84  ? 297 ASP A C   1 
ATOM   2106 O O   . ASP A 1 271 ? -13.881 -34.470 37.413 1.00 86.78  ? 297 ASP A O   1 
ATOM   2107 C CB  . ASP A 1 271 ? -12.386 -37.217 37.820 1.00 92.06  ? 297 ASP A CB  1 
ATOM   2108 C CG  . ASP A 1 271 ? -11.953 -38.637 37.478 1.00 102.56 ? 297 ASP A CG  1 
ATOM   2109 O OD1 . ASP A 1 271 ? -10.747 -38.945 37.633 1.00 107.02 ? 297 ASP A OD1 1 
ATOM   2110 O OD2 . ASP A 1 271 ? -12.816 -39.436 37.037 1.00 101.77 ? 297 ASP A OD2 1 
ATOM   2111 N N   . SER A 1 272 ? -11.786 -34.171 36.665 1.00 82.63  ? 298 SER A N   1 
ATOM   2112 C CA  . SER A 1 272 ? -11.732 -32.768 37.037 1.00 79.76  ? 298 SER A CA  1 
ATOM   2113 C C   . SER A 1 272 ? -11.367 -31.934 35.816 1.00 71.60  ? 298 SER A C   1 
ATOM   2114 O O   . SER A 1 272 ? -10.697 -32.408 34.894 1.00 69.31  ? 298 SER A O   1 
ATOM   2115 C CB  . SER A 1 272 ? -10.725 -32.529 38.169 1.00 69.48  ? 298 SER A CB  1 
ATOM   2116 O OG  . SER A 1 272 ? -10.645 -31.143 38.480 1.00 81.28  ? 298 SER A OG  1 
ATOM   2117 N N   . LEU A 1 273 ? -11.788 -30.666 35.849 1.00 68.47  ? 299 LEU A N   1 
ATOM   2118 C CA  . LEU A 1 273 ? -11.359 -29.705 34.841 1.00 67.69  ? 299 LEU A CA  1 
ATOM   2119 C C   . LEU A 1 273 ? -9.835  -29.637 34.738 1.00 68.69  ? 299 LEU A C   1 
ATOM   2120 O O   . LEU A 1 273 ? -9.283  -29.599 33.631 1.00 66.28  ? 299 LEU A O   1 
ATOM   2121 C CB  . LEU A 1 273 ? -11.929 -28.320 35.163 1.00 70.72  ? 299 LEU A CB  1 
ATOM   2122 C CG  . LEU A 1 273 ? -13.307 -27.944 34.596 1.00 82.98  ? 299 LEU A CG  1 
ATOM   2123 C CD1 . LEU A 1 273 ? -14.285 -29.129 34.582 1.00 83.85  ? 299 LEU A CD1 1 
ATOM   2124 C CD2 . LEU A 1 273 ? -13.900 -26.764 35.367 1.00 78.53  ? 299 LEU A CD2 1 
ATOM   2125 N N   . VAL A 1 274 ? -9.129  -29.633 35.875 1.00 65.21  ? 300 VAL A N   1 
ATOM   2126 C CA  . VAL A 1 274 ? -7.677  -29.482 35.794 1.00 65.53  ? 300 VAL A CA  1 
ATOM   2127 C C   . VAL A 1 274 ? -7.042  -30.761 35.256 1.00 63.70  ? 300 VAL A C   1 
ATOM   2128 O O   . VAL A 1 274 ? -6.020  -30.708 34.558 1.00 62.68  ? 300 VAL A O   1 
ATOM   2129 C CB  . VAL A 1 274 ? -7.079  -29.090 37.166 1.00 71.85  ? 300 VAL A CB  1 
ATOM   2130 C CG1 . VAL A 1 274 ? -7.817  -27.908 37.773 1.00 66.59  ? 300 VAL A CG1 1 
ATOM   2131 C CG2 . VAL A 1 274 ? -7.114  -30.264 38.121 1.00 63.87  ? 300 VAL A CG2 1 
ATOM   2132 N N   . GLY A 1 275 ? -7.667  -31.916 35.499 1.00 65.91  ? 301 GLY A N   1 
ATOM   2133 C CA  . GLY A 1 275 ? -7.201  -33.138 34.868 1.00 62.06  ? 301 GLY A CA  1 
ATOM   2134 C C   . GLY A 1 275 ? -7.376  -33.103 33.363 1.00 68.91  ? 301 GLY A C   1 
ATOM   2135 O O   . GLY A 1 275 ? -6.503  -33.555 32.613 1.00 69.31  ? 301 GLY A O   1 
ATOM   2136 N N   . THR A 1 276 ? -8.505  -32.558 32.902 1.00 65.10  ? 302 THR A N   1 
ATOM   2137 C CA  . THR A 1 276 ? -8.713  -32.390 31.471 1.00 62.93  ? 302 THR A CA  1 
ATOM   2138 C C   . THR A 1 276 ? -7.666  -31.444 30.890 1.00 66.06  ? 302 THR A C   1 
ATOM   2139 O O   . THR A 1 276 ? -7.045  -31.741 29.858 1.00 57.51  ? 302 THR A O   1 
ATOM   2140 C CB  . THR A 1 276 ? -10.136 -31.881 31.201 1.00 69.21  ? 302 THR A CB  1 
ATOM   2141 O OG1 . THR A 1 276 ? -11.109 -32.846 31.649 1.00 67.34  ? 302 THR A OG1 1 
ATOM   2142 C CG2 . THR A 1 276 ? -10.328 -31.638 29.723 1.00 62.11  ? 302 THR A CG2 1 
ATOM   2143 N N   . TYR A 1 277 ? -7.455  -30.293 31.546 1.00 58.59  ? 303 TYR A N   1 
ATOM   2144 C CA  . TYR A 1 277 ? -6.438  -29.353 31.083 1.00 60.86  ? 303 TYR A CA  1 
ATOM   2145 C C   . TYR A 1 277 ? -5.063  -30.009 31.021 1.00 64.33  ? 303 TYR A C   1 
ATOM   2146 O O   . TYR A 1 277 ? -4.318  -29.802 30.056 1.00 63.77  ? 303 TYR A O   1 
ATOM   2147 C CB  . TYR A 1 277 ? -6.413  -28.117 31.968 1.00 65.46  ? 303 TYR A CB  1 
ATOM   2148 C CG  . TYR A 1 277 ? -7.638  -27.238 31.834 1.00 66.70  ? 303 TYR A CG  1 
ATOM   2149 C CD1 . TYR A 1 277 ? -8.382  -27.212 30.654 1.00 67.16  ? 303 TYR A CD1 1 
ATOM   2150 C CD2 . TYR A 1 277 ? -8.058  -26.434 32.891 1.00 66.94  ? 303 TYR A CD2 1 
ATOM   2151 C CE1 . TYR A 1 277 ? -9.508  -26.403 30.537 1.00 69.67  ? 303 TYR A CE1 1 
ATOM   2152 C CE2 . TYR A 1 277 ? -9.189  -25.624 32.786 1.00 69.00  ? 303 TYR A CE2 1 
ATOM   2153 C CZ  . TYR A 1 277 ? -9.904  -25.610 31.610 1.00 71.80  ? 303 TYR A CZ  1 
ATOM   2154 O OH  . TYR A 1 277 ? -11.019 -24.809 31.501 1.00 78.70  ? 303 TYR A OH  1 
ATOM   2155 N N   . SER A 1 278 ? -4.734  -30.866 32.002 1.00 66.43  ? 304 SER A N   1 
ATOM   2156 C CA  . SER A 1 278 ? -3.399  -31.477 32.020 1.00 67.40  ? 304 SER A CA  1 
ATOM   2157 C C   . SER A 1 278 ? -3.310  -32.695 31.115 1.00 67.77  ? 304 SER A C   1 
ATOM   2158 O O   . SER A 1 278 ? -2.233  -32.969 30.570 1.00 68.77  ? 304 SER A O   1 
ATOM   2159 C CB  . SER A 1 278 ? -3.021  -31.919 33.452 1.00 60.66  ? 304 SER A CB  1 
ATOM   2160 O OG  . SER A 1 278 ? -2.904  -30.832 34.325 1.00 66.78  ? 304 SER A OG  1 
ATOM   2161 N N   . LYS A 1 279 ? -4.437  -33.381 30.875 1.00 60.88  ? 305 LYS A N   1 
ATOM   2162 C CA  . LYS A 1 279 ? -4.466  -34.402 29.831 1.00 66.50  ? 305 LYS A CA  1 
ATOM   2163 C C   . LYS A 1 279 ? -4.200  -33.789 28.463 1.00 65.77  ? 305 LYS A C   1 
ATOM   2164 O O   . LYS A 1 279 ? -3.484  -34.367 27.635 1.00 67.70  ? 305 LYS A O   1 
ATOM   2165 C CB  . LYS A 1 279 ? -5.817  -35.114 29.831 1.00 68.26  ? 305 LYS A CB  1 
ATOM   2166 C CG  . LYS A 1 279 ? -5.787  -36.548 30.327 1.00 72.83  ? 305 LYS A CG  1 
ATOM   2167 C CD  . LYS A 1 279 ? -7.116  -36.955 30.972 1.00 75.08  ? 305 LYS A CD  1 
ATOM   2168 C CE  . LYS A 1 279 ? -7.153  -38.456 31.314 1.00 79.95  ? 305 LYS A CE  1 
ATOM   2169 N NZ  . LYS A 1 279 ? -7.124  -39.313 30.071 1.00 85.85  ? 305 LYS A NZ  1 
ATOM   2170 N N   . ILE A 1 280 ? -4.774  -32.617 28.204 1.00 64.11  ? 306 ILE A N   1 
ATOM   2171 C CA  . ILE A 1 280 ? -4.601  -31.982 26.906 1.00 64.12  ? 306 ILE A CA  1 
ATOM   2172 C C   . ILE A 1 280 ? -3.158  -31.538 26.729 1.00 64.96  ? 306 ILE A C   1 
ATOM   2173 O O   . ILE A 1 280 ? -2.563  -31.713 25.657 1.00 63.47  ? 306 ILE A O   1 
ATOM   2174 C CB  . ILE A 1 280 ? -5.581  -30.808 26.744 1.00 60.16  ? 306 ILE A CB  1 
ATOM   2175 C CG1 . ILE A 1 280 ? -7.010  -31.321 26.559 1.00 58.30  ? 306 ILE A CG1 1 
ATOM   2176 C CG2 . ILE A 1 280 ? -5.169  -29.915 25.587 1.00 55.66  ? 306 ILE A CG2 1 
ATOM   2177 C CD1 . ILE A 1 280 ? -8.007  -30.320 27.011 1.00 53.04  ? 306 ILE A CD1 1 
ATOM   2178 N N   . MET A 1 281 ? -2.585  -30.907 27.762 1.00 66.85  ? 307 MET A N   1 
ATOM   2179 C CA  . MET A 1 281 ? -1.196  -30.483 27.642 1.00 70.94  ? 307 MET A CA  1 
ATOM   2180 C C   . MET A 1 281 ? -0.281  -31.665 27.401 1.00 63.77  ? 307 MET A C   1 
ATOM   2181 O O   . MET A 1 281 ? 0.660   -31.568 26.614 1.00 68.30  ? 307 MET A O   1 
ATOM   2182 C CB  . MET A 1 281 ? -0.761  -29.738 28.894 1.00 66.14  ? 307 MET A CB  1 
ATOM   2183 C CG  . MET A 1 281 ? -1.647  -28.564 29.182 1.00 71.61  ? 307 MET A CG  1 
ATOM   2184 S SD  . MET A 1 281 ? -1.429  -27.271 27.943 1.00 82.79  ? 307 MET A SD  1 
ATOM   2185 C CE  . MET A 1 281 ? -0.896  -25.963 29.060 1.00 79.51  ? 307 MET A CE  1 
ATOM   2186 N N   . ASP A 1 282 ? -0.613  -32.813 27.972 1.00 65.27  ? 308 ASP A N   1 
ATOM   2187 C CA  . ASP A 1 282 ? 0.147   -34.049 27.818 1.00 69.54  ? 308 ASP A CA  1 
ATOM   2188 C C   . ASP A 1 282 ? -0.444  -34.972 26.747 1.00 71.75  ? 308 ASP A C   1 
ATOM   2189 O O   . ASP A 1 282 ? -0.411  -36.202 26.889 1.00 69.11  ? 308 ASP A O   1 
ATOM   2190 C CB  . ASP A 1 282 ? 0.209   -34.742 29.178 1.00 74.83  ? 308 ASP A CB  1 
ATOM   2191 C CG  . ASP A 1 282 ? 1.295   -35.793 29.260 1.00 81.63  ? 308 ASP A CG  1 
ATOM   2192 O OD1 . ASP A 1 282 ? 2.374   -35.590 28.646 1.00 74.27  ? 308 ASP A OD1 1 
ATOM   2193 O OD2 . ASP A 1 282 ? 1.045   -36.821 29.941 1.00 80.07  ? 308 ASP A OD2 1 
ATOM   2194 N N   . HIS A 1 283 ? -0.973  -34.413 25.649 1.00 63.33  ? 309 HIS A N   1 
ATOM   2195 C CA  . HIS A 1 283 ? -1.717  -35.242 24.700 1.00 69.32  ? 309 HIS A CA  1 
ATOM   2196 C C   . HIS A 1 283 ? -0.831  -36.278 24.005 1.00 72.19  ? 309 HIS A C   1 
ATOM   2197 O O   . HIS A 1 283 ? -1.315  -37.369 23.678 1.00 69.01  ? 309 HIS A O   1 
ATOM   2198 C CB  . HIS A 1 283 ? -2.421  -34.366 23.670 1.00 63.28  ? 309 HIS A CB  1 
ATOM   2199 C CG  . HIS A 1 283 ? -1.490  -33.545 22.847 1.00 62.46  ? 309 HIS A CG  1 
ATOM   2200 N ND1 . HIS A 1 283 ? -0.936  -34.008 21.671 1.00 61.08  ? 309 HIS A ND1 1 
ATOM   2201 C CD2 . HIS A 1 283 ? -1.002  -32.294 23.032 1.00 60.27  ? 309 HIS A CD2 1 
ATOM   2202 C CE1 . HIS A 1 283 ? -0.149  -33.073 21.164 1.00 62.86  ? 309 HIS A CE1 1 
ATOM   2203 N NE2 . HIS A 1 283 ? -0.170  -32.023 21.971 1.00 62.38  ? 309 HIS A NE2 1 
ATOM   2204 N N   . LYS A 1 284 ? 0.460   -35.977 23.783 1.00 68.41  ? 310 LYS A N   1 
ATOM   2205 C CA  . LYS A 1 284 ? 1.324   -36.950 23.118 1.00 70.74  ? 310 LYS A CA  1 
ATOM   2206 C C   . LYS A 1 284 ? 1.357   -38.281 23.866 1.00 73.34  ? 310 LYS A C   1 
ATOM   2207 O O   . LYS A 1 284 ? 1.579   -39.323 23.242 1.00 83.09  ? 310 LYS A O   1 
ATOM   2208 C CB  . LYS A 1 284 ? 2.748   -36.391 22.930 1.00 66.35  ? 310 LYS A CB  1 
ATOM   2209 N N   . ASN A 1 285 ? 1.080   -38.287 25.173 1.00 71.07  ? 311 ASN A N   1 
ATOM   2210 C CA  . ASN A 1 285 ? 1.020   -39.534 25.920 1.00 73.64  ? 311 ASN A CA  1 
ATOM   2211 C C   . ASN A 1 285 ? -0.368  -39.906 26.407 1.00 76.38  ? 311 ASN A C   1 
ATOM   2212 O O   . ASN A 1 285 ? -0.604  -41.088 26.673 1.00 79.37  ? 311 ASN A O   1 
ATOM   2213 C CB  . ASN A 1 285 ? 1.927   -39.476 27.159 1.00 78.83  ? 311 ASN A CB  1 
ATOM   2214 C CG  . ASN A 1 285 ? 3.327   -39.060 26.833 1.00 73.94  ? 311 ASN A CG  1 
ATOM   2215 O OD1 . ASN A 1 285 ? 3.992   -39.679 26.002 1.00 76.01  ? 311 ASN A OD1 1 
ATOM   2216 N ND2 . ASN A 1 285 ? 3.791   -38.006 27.484 1.00 72.18  ? 311 ASN A ND2 1 
ATOM   2217 N N   . SER A 1 286 ? -1.295  -38.949 26.507 1.00 76.75  ? 312 SER A N   1 
ATOM   2218 C CA  . SER A 1 286 ? -2.607  -39.248 27.076 1.00 76.24  ? 312 SER A CA  1 
ATOM   2219 C C   . SER A 1 286 ? -3.620  -39.716 26.040 1.00 75.81  ? 312 SER A C   1 
ATOM   2220 O O   . SER A 1 286 ? -4.571  -40.415 26.410 1.00 81.20  ? 312 SER A O   1 
ATOM   2221 C CB  . SER A 1 286 ? -3.168  -38.030 27.830 1.00 72.61  ? 312 SER A CB  1 
ATOM   2222 O OG  . SER A 1 286 ? -3.624  -37.012 26.952 1.00 69.63  ? 312 SER A OG  1 
ATOM   2223 N N   . LEU A 1 287 ? -3.441  -39.354 24.762 1.00 77.12  ? 313 LEU A N   1 
ATOM   2224 C CA  . LEU A 1 287 ? -4.323  -39.839 23.703 1.00 76.41  ? 313 LEU A CA  1 
ATOM   2225 C C   . LEU A 1 287 ? -4.143  -41.346 23.562 1.00 78.97  ? 313 LEU A C   1 
ATOM   2226 O O   . LEU A 1 287 ? -3.040  -41.825 23.283 1.00 75.95  ? 313 LEU A O   1 
ATOM   2227 C CB  . LEU A 1 287 ? -4.031  -39.135 22.377 1.00 67.67  ? 313 LEU A CB  1 
ATOM   2228 C CG  . LEU A 1 287 ? -4.798  -39.737 21.192 1.00 69.21  ? 313 LEU A CG  1 
ATOM   2229 C CD1 . LEU A 1 287 ? -6.294  -39.736 21.485 1.00 67.28  ? 313 LEU A CD1 1 
ATOM   2230 C CD2 . LEU A 1 287 ? -4.498  -39.006 19.885 1.00 68.42  ? 313 LEU A CD2 1 
ATOM   2231 N N   . CYS A 1 288 ? -5.221  -42.094 23.759 1.00 80.98  ? 314 CYS A N   1 
ATOM   2232 C CA  . CYS A 1 288 ? -5.126  -43.546 23.790 1.00 86.75  ? 314 CYS A CA  1 
ATOM   2233 C C   . CYS A 1 288 ? -6.455  -44.141 23.343 1.00 89.89  ? 314 CYS A C   1 
ATOM   2234 O O   . CYS A 1 288 ? -7.499  -43.841 23.934 1.00 89.77  ? 314 CYS A O   1 
ATOM   2235 C CB  . CYS A 1 288 ? -4.756  -44.023 25.209 1.00 89.41  ? 314 CYS A CB  1 
ATOM   2236 S SG  . CYS A 1 288 ? -4.847  -45.814 25.529 1.00 104.21 ? 314 CYS A SG  1 
ATOM   2237 N N   . PHE A 1 289 ? -6.407  -45.001 22.313 1.00 87.36  ? 315 PHE A N   1 
ATOM   2238 C CA  . PHE A 1 289 ? -7.654  -45.617 21.869 1.00 90.57  ? 315 PHE A CA  1 
ATOM   2239 C C   . PHE A 1 289 ? -7.943  -46.865 22.697 1.00 95.48  ? 315 PHE A C   1 
ATOM   2240 O O   . PHE A 1 289 ? -7.033  -47.658 22.961 1.00 97.21  ? 315 PHE A O   1 
ATOM   2241 C CB  . PHE A 1 289 ? -7.586  -46.003 20.392 1.00 84.03  ? 315 PHE A CB  1 
ATOM   2242 C CG  . PHE A 1 289 ? -7.369  -44.842 19.475 1.00 83.34  ? 315 PHE A CG  1 
ATOM   2243 C CD1 . PHE A 1 289 ? -6.086  -44.423 19.157 1.00 81.96  ? 315 PHE A CD1 1 
ATOM   2244 C CD2 . PHE A 1 289 ? -8.448  -44.156 18.934 1.00 79.51  ? 315 PHE A CD2 1 
ATOM   2245 C CE1 . PHE A 1 289 ? -5.876  -43.336 18.307 1.00 80.72  ? 315 PHE A CE1 1 
ATOM   2246 C CE2 . PHE A 1 289 ? -8.248  -43.078 18.087 1.00 74.09  ? 315 PHE A CE2 1 
ATOM   2247 C CZ  . PHE A 1 289 ? -6.957  -42.665 17.773 1.00 74.63  ? 315 PHE A CZ  1 
ATOM   2248 N N   . PRO A 1 290 ? -9.190  -47.059 23.118 1.00 99.11  ? 316 PRO A N   1 
ATOM   2249 C CA  . PRO A 1 290 ? -9.526  -48.288 23.841 1.00 103.07 ? 316 PRO A CA  1 
ATOM   2250 C C   . PRO A 1 290 ? -9.230  -49.514 22.989 1.00 107.15 ? 316 PRO A C   1 
ATOM   2251 O O   . PRO A 1 290 ? -9.449  -49.526 21.775 1.00 105.37 ? 316 PRO A O   1 
ATOM   2252 C CB  . PRO A 1 290 ? -11.025 -48.137 24.124 1.00 102.61 ? 316 PRO A CB  1 
ATOM   2253 C CG  . PRO A 1 290 ? -11.265 -46.662 24.099 1.00 95.92  ? 316 PRO A CG  1 
ATOM   2254 C CD  . PRO A 1 290 ? -10.338 -46.138 23.037 1.00 95.60  ? 316 PRO A CD  1 
ATOM   2255 N N   . GLU A 1 291 ? -8.711  -50.549 23.651 1.00 111.00 ? 317 GLU A N   1 
ATOM   2256 C CA  . GLU A 1 291 ? -8.317  -51.770 22.958 1.00 111.13 ? 317 GLU A CA  1 
ATOM   2257 C C   . GLU A 1 291 ? -9.509  -52.431 22.278 1.00 109.74 ? 317 GLU A C   1 
ATOM   2258 O O   . GLU A 1 291 ? -9.366  -52.995 21.186 1.00 113.64 ? 317 GLU A O   1 
ATOM   2259 C CB  . GLU A 1 291 ? -7.650  -52.731 23.949 1.00 109.73 ? 317 GLU A CB  1 
ATOM   2260 C CG  . GLU A 1 291 ? -8.471  -53.036 25.230 1.00 112.23 ? 317 GLU A CG  1 
ATOM   2261 C CD  . GLU A 1 291 ? -8.630  -51.838 26.185 1.00 113.57 ? 317 GLU A CD  1 
ATOM   2262 O OE1 . GLU A 1 291 ? -9.749  -51.643 26.713 1.00 110.77 ? 317 GLU A OE1 1 
ATOM   2263 O OE2 . GLU A 1 291 ? -7.649  -51.089 26.402 1.00 114.28 ? 317 GLU A OE2 1 
ATOM   2264 N N   . ASP A 1 292 ? -10.691 -52.352 22.891 1.00 107.06 ? 318 ASP A N   1 
ATOM   2265 C CA  . ASP A 1 292 ? -11.908 -52.918 22.324 1.00 108.69 ? 318 ASP A CA  1 
ATOM   2266 C C   . ASP A 1 292 ? -12.562 -52.000 21.299 1.00 108.23 ? 318 ASP A C   1 
ATOM   2267 O O   . ASP A 1 292 ? -13.627 -52.340 20.773 1.00 106.37 ? 318 ASP A O   1 
ATOM   2268 C CB  . ASP A 1 292 ? -12.913 -53.252 23.437 1.00 111.11 ? 318 ASP A CB  1 
ATOM   2269 C CG  . ASP A 1 292 ? -12.906 -52.231 24.576 1.00 114.41 ? 318 ASP A CG  1 
ATOM   2270 O OD1 . ASP A 1 292 ? -12.289 -51.149 24.429 1.00 112.87 ? 318 ASP A OD1 1 
ATOM   2271 O OD2 . ASP A 1 292 ? -13.521 -52.518 25.627 1.00 110.59 ? 318 ASP A OD2 1 
ATOM   2272 N N   . ALA A 1 293 ? -11.959 -50.855 21.000 1.00 109.29 ? 319 ALA A N   1 
ATOM   2273 C CA  . ALA A 1 293 ? -12.524 -49.939 20.018 1.00 104.89 ? 319 ALA A CA  1 
ATOM   2274 C C   . ALA A 1 293 ? -12.081 -50.404 18.641 1.00 101.11 ? 319 ALA A C   1 
ATOM   2275 O O   . ALA A 1 293 ? -10.899 -50.305 18.292 1.00 103.25 ? 319 ALA A O   1 
ATOM   2276 C CB  . ALA A 1 293 ? -12.077 -48.506 20.287 1.00 102.08 ? 319 ALA A CB  1 
ATOM   2277 N N   . GLU A 1 294 ? -13.030 -50.919 17.862 1.00 98.32  ? 320 GLU A N   1 
ATOM   2278 C CA  . GLU A 1 294 ? -12.758 -51.408 16.512 1.00 97.39  ? 320 GLU A CA  1 
ATOM   2279 C C   . GLU A 1 294 ? -12.854 -50.228 15.549 1.00 90.79  ? 320 GLU A C   1 
ATOM   2280 O O   . GLU A 1 294 ? -13.822 -50.061 14.804 1.00 90.44  ? 320 GLU A O   1 
ATOM   2281 C CB  . GLU A 1 294 ? -13.722 -52.527 16.142 1.00 101.26 ? 320 GLU A CB  1 
ATOM   2282 C CG  . GLU A 1 294 ? -13.492 -53.832 16.900 1.00 107.84 ? 320 GLU A CG  1 
ATOM   2283 C CD  . GLU A 1 294 ? -14.393 -54.952 16.391 1.00 114.07 ? 320 GLU A CD  1 
ATOM   2284 O OE1 . GLU A 1 294 ? -14.730 -55.871 17.169 1.00 112.84 ? 320 GLU A OE1 1 
ATOM   2285 O OE2 . GLU A 1 294 ? -14.770 -54.905 15.201 1.00 111.57 ? 320 GLU A OE2 1 
ATOM   2286 N N   . ILE A 1 295 ? -11.826 -49.387 15.582 1.00 87.54  ? 321 ILE A N   1 
ATOM   2287 C CA  . ILE A 1 295 ? -11.727 -48.220 14.717 1.00 77.21  ? 321 ILE A CA  1 
ATOM   2288 C C   . ILE A 1 295 ? -10.836 -48.569 13.541 1.00 80.46  ? 321 ILE A C   1 
ATOM   2289 O O   . ILE A 1 295 ? -9.766  -49.170 13.714 1.00 82.25  ? 321 ILE A O   1 
ATOM   2290 C CB  . ILE A 1 295 ? -11.167 -47.009 15.477 1.00 79.37  ? 321 ILE A CB  1 
ATOM   2291 C CG1 . ILE A 1 295 ? -11.967 -46.785 16.754 1.00 84.11  ? 321 ILE A CG1 1 
ATOM   2292 C CG2 . ILE A 1 295 ? -11.203 -45.770 14.614 1.00 73.40  ? 321 ILE A CG2 1 
ATOM   2293 C CD1 . ILE A 1 295 ? -11.888 -45.382 17.252 1.00 82.59  ? 321 ILE A CD1 1 
ATOM   2294 N N   . SER A 1 296 ? -11.293 -48.229 12.342 1.00 74.94  ? 322 SER A N   1 
ATOM   2295 C CA  . SER A 1 296 ? -10.484 -48.470 11.169 1.00 71.07  ? 322 SER A CA  1 
ATOM   2296 C C   . SER A 1 296 ? -9.168  -47.699 11.273 1.00 74.87  ? 322 SER A C   1 
ATOM   2297 O O   . SER A 1 296 ? -8.980  -46.821 12.125 1.00 69.27  ? 322 SER A O   1 
ATOM   2298 C CB  . SER A 1 296 ? -11.244 -48.072 9.911  1.00 61.51  ? 322 SER A CB  1 
ATOM   2299 O OG  . SER A 1 296 ? -11.041 -46.708 9.604  1.00 62.77  ? 322 SER A OG  1 
ATOM   2300 N N   . LYS A 1 297 ? -8.261  -48.021 10.360 1.00 69.91  ? 323 LYS A N   1 
ATOM   2301 C CA  . LYS A 1 297 ? -6.910  -47.493 10.428 1.00 71.35  ? 323 LYS A CA  1 
ATOM   2302 C C   . LYS A 1 297 ? -6.818  -46.164 9.711  1.00 71.39  ? 323 LYS A C   1 
ATOM   2303 O O   . LYS A 1 297 ? -6.002  -45.315 10.097 1.00 69.83  ? 323 LYS A O   1 
ATOM   2304 C CB  . LYS A 1 297 ? -5.904  -48.467 9.776  1.00 73.35  ? 323 LYS A CB  1 
ATOM   2305 C CG  . LYS A 1 297 ? -5.821  -49.922 10.328 1.00 85.74  ? 323 LYS A CG  1 
ATOM   2306 C CD  . LYS A 1 297 ? -7.162  -50.723 10.349 1.00 91.07  ? 323 LYS A CD  1 
ATOM   2307 C CE  . LYS A 1 297 ? -7.681  -51.098 8.950  1.00 83.58  ? 323 LYS A CE  1 
ATOM   2308 N NZ  . LYS A 1 297 ? -9.129  -51.487 8.974  1.00 79.62  ? 323 LYS A NZ  1 
ATOM   2309 N N   . HIS A 1 298 ? -7.743  -45.913 8.779  1.00 68.76  ? 324 HIS A N   1 
ATOM   2310 C CA  . HIS A 1 298 ? -7.875  -44.574 8.222  1.00 67.24  ? 324 HIS A CA  1 
ATOM   2311 C C   . HIS A 1 298 ? -8.486  -43.618 9.235  1.00 65.68  ? 324 HIS A C   1 
ATOM   2312 O O   . HIS A 1 298 ? -8.071  -42.455 9.324  1.00 63.50  ? 324 HIS A O   1 
ATOM   2313 C CB  . HIS A 1 298 ? -8.722  -44.630 6.961  1.00 63.60  ? 324 HIS A CB  1 
ATOM   2314 C CG  . HIS A 1 298 ? -8.003  -45.220 5.794  1.00 71.36  ? 324 HIS A CG  1 
ATOM   2315 N ND1 . HIS A 1 298 ? -6.627  -45.257 5.715  1.00 74.61  ? 324 HIS A ND1 1 
ATOM   2316 C CD2 . HIS A 1 298 ? -8.463  -45.774 4.645  1.00 70.11  ? 324 HIS A CD2 1 
ATOM   2317 C CE1 . HIS A 1 298 ? -6.269  -45.812 4.570  1.00 70.72  ? 324 HIS A CE1 1 
ATOM   2318 N NE2 . HIS A 1 298 ? -7.365  -46.135 3.903  1.00 73.07  ? 324 HIS A NE2 1 
ATOM   2319 N N   . ALA A 1 299 ? -9.453  -44.097 10.021 1.00 62.90  ? 325 ALA A N   1 
ATOM   2320 C CA  . ALA A 1 299 ? -10.082 -43.252 11.021 1.00 60.93  ? 325 ALA A CA  1 
ATOM   2321 C C   . ALA A 1 299 ? -9.097  -42.912 12.132 1.00 63.26  ? 325 ALA A C   1 
ATOM   2322 O O   . ALA A 1 299 ? -8.944  -41.742 12.505 1.00 60.87  ? 325 ALA A O   1 
ATOM   2323 C CB  . ALA A 1 299 ? -11.324 -43.948 11.565 1.00 60.92  ? 325 ALA A CB  1 
ATOM   2324 N N   . LYS A 1 300 ? -8.407  -43.923 12.660 1.00 64.72  ? 326 LYS A N   1 
ATOM   2325 C CA  . LYS A 1 300 ? -7.390  -43.683 13.676 1.00 66.59  ? 326 LYS A CA  1 
ATOM   2326 C C   . LYS A 1 300 ? -6.321  -42.714 13.180 1.00 60.84  ? 326 LYS A C   1 
ATOM   2327 O O   . LYS A 1 300 ? -5.898  -41.812 13.915 1.00 60.42  ? 326 LYS A O   1 
ATOM   2328 C CB  . LYS A 1 300 ? -6.762  -45.016 14.091 1.00 69.00  ? 326 LYS A CB  1 
ATOM   2329 C CG  . LYS A 1 300 ? -7.101  -45.444 15.515 1.00 75.89  ? 326 LYS A CG  1 
ATOM   2330 C CD  . LYS A 1 300 ? -6.404  -46.749 15.925 1.00 80.02  ? 326 LYS A CD  1 
ATOM   2331 C CE  . LYS A 1 300 ? -7.191  -47.989 15.499 1.00 85.79  ? 326 LYS A CE  1 
ATOM   2332 N NZ  . LYS A 1 300 ? -7.097  -49.107 16.494 1.00 94.87  ? 326 LYS A NZ  1 
ATOM   2333 N N   . ASN A 1 301 ? -5.910  -42.849 11.923 1.00 56.48  ? 327 ASN A N   1 
ATOM   2334 C CA  . ASN A 1 301 ? -4.899  -41.956 11.358 1.00 58.34  ? 327 ASN A CA  1 
ATOM   2335 C C   . ASN A 1 301 ? -5.408  -40.515 11.271 1.00 64.71  ? 327 ASN A C   1 
ATOM   2336 O O   . ASN A 1 301 ? -4.677  -39.567 11.598 1.00 56.25  ? 327 ASN A O   1 
ATOM   2337 C CB  . ASN A 1 301 ? -4.469  -42.484 9.984  1.00 58.83  ? 327 ASN A CB  1 
ATOM   2338 C CG  . ASN A 1 301 ? -3.412  -41.612 9.294  1.00 67.15  ? 327 ASN A CG  1 
ATOM   2339 O OD1 . ASN A 1 301 ? -3.703  -40.515 8.805  1.00 64.01  ? 327 ASN A OD1 1 
ATOM   2340 N ND2 . ASN A 1 301 ? -2.178  -42.124 9.215  1.00 65.70  ? 327 ASN A ND2 1 
ATOM   2341 N N   . LEU A 1 302 ? -6.660  -40.316 10.828 1.00 60.64  ? 328 LEU A N   1 
ATOM   2342 C CA  . LEU A 1 302 ? -7.155  -38.945 10.721 1.00 56.99  ? 328 LEU A CA  1 
ATOM   2343 C C   . LEU A 1 302 ? -7.277  -38.294 12.097 1.00 52.59  ? 328 LEU A C   1 
ATOM   2344 O O   . LEU A 1 302 ? -6.878  -37.139 12.272 1.00 56.38  ? 328 LEU A O   1 
ATOM   2345 C CB  . LEU A 1 302 ? -8.490  -38.906 9.973  1.00 56.00  ? 328 LEU A CB  1 
ATOM   2346 C CG  . LEU A 1 302 ? -9.144  -37.528 9.924  1.00 49.57  ? 328 LEU A CG  1 
ATOM   2347 C CD1 . LEU A 1 302 ? -8.311  -36.545 9.143  1.00 45.40  ? 328 LEU A CD1 1 
ATOM   2348 C CD2 . LEU A 1 302 ? -10.533 -37.634 9.287  1.00 57.18  ? 328 LEU A CD2 1 
ATOM   2349 N N   . ILE A 1 303 ? -7.816  -39.022 13.076 1.00 51.32  ? 329 ILE A N   1 
ATOM   2350 C CA  . ILE A 1 303 ? -7.925  -38.535 14.446 1.00 56.52  ? 329 ILE A CA  1 
ATOM   2351 C C   . ILE A 1 303 ? -6.557  -38.138 15.000 1.00 62.07  ? 329 ILE A C   1 
ATOM   2352 O O   . ILE A 1 303 ? -6.398  -37.062 15.607 1.00 58.47  ? 329 ILE A O   1 
ATOM   2353 C CB  . ILE A 1 303 ? -8.588  -39.596 15.337 1.00 55.30  ? 329 ILE A CB  1 
ATOM   2354 C CG1 . ILE A 1 303 ? -10.059 -39.818 14.974 1.00 61.51  ? 329 ILE A CG1 1 
ATOM   2355 C CG2 . ILE A 1 303 ? -8.471  -39.173 16.775 1.00 55.67  ? 329 ILE A CG2 1 
ATOM   2356 C CD1 . ILE A 1 303 ? -10.693 -40.931 15.768 1.00 55.95  ? 329 ILE A CD1 1 
ATOM   2357 N N   . CYS A 1 304 ? -5.553  -39.012 14.831 1.00 64.78  ? 330 CYS A N   1 
ATOM   2358 C CA  . CYS A 1 304 ? -4.236  -38.659 15.367 1.00 60.11  ? 330 CYS A CA  1 
ATOM   2359 C C   . CYS A 1 304 ? -3.565  -37.569 14.577 1.00 57.28  ? 330 CYS A C   1 
ATOM   2360 O O   . CYS A 1 304 ? -2.797  -36.809 15.160 1.00 62.72  ? 330 CYS A O   1 
ATOM   2361 C CB  . CYS A 1 304 ? -3.285  -39.875 15.321 1.00 55.54  ? 330 CYS A CB  1 
ATOM   2362 S SG  . CYS A 1 304 ? -3.701  -41.238 16.405 1.00 71.46  ? 330 CYS A SG  1 
ATOM   2363 N N   . ALA A 1 305 ? -3.996  -37.353 13.342 1.00 54.01  ? 331 ALA A N   1 
ATOM   2364 C CA  . ALA A 1 305 ? -3.490  -36.253 12.538 1.00 52.22  ? 331 ALA A CA  1 
ATOM   2365 C C   . ALA A 1 305 ? -4.049  -34.894 12.942 1.00 59.11  ? 331 ALA A C   1 
ATOM   2366 O O   . ALA A 1 305 ? -3.437  -33.855 12.613 1.00 56.57  ? 331 ALA A O   1 
ATOM   2367 C CB  . ALA A 1 305 ? -3.764  -36.535 11.057 1.00 54.39  ? 331 ALA A CB  1 
ATOM   2368 N N   . PHE A 1 306 ? -5.236  -34.878 13.561 1.00 57.79  ? 332 PHE A N   1 
ATOM   2369 C CA  . PHE A 1 306 ? -5.870  -33.682 14.095 1.00 53.85  ? 332 PHE A CA  1 
ATOM   2370 C C   . PHE A 1 306 ? -5.439  -33.421 15.535 1.00 51.27  ? 332 PHE A C   1 
ATOM   2371 O O   . PHE A 1 306 ? -5.247  -32.265 15.942 1.00 53.41  ? 332 PHE A O   1 
ATOM   2372 C CB  . PHE A 1 306 ? -7.406  -33.841 14.053 1.00 53.50  ? 332 PHE A CB  1 
ATOM   2373 C CG  . PHE A 1 306 ? -8.037  -33.539 12.712 1.00 48.44  ? 332 PHE A CG  1 
ATOM   2374 C CD1 . PHE A 1 306 ? -7.557  -32.530 11.920 1.00 50.38  ? 332 PHE A CD1 1 
ATOM   2375 C CD2 . PHE A 1 306 ? -9.157  -34.250 12.284 1.00 48.62  ? 332 PHE A CD2 1 
ATOM   2376 C CE1 . PHE A 1 306 ? -8.151  -32.224 10.714 1.00 51.61  ? 332 PHE A CE1 1 
ATOM   2377 C CE2 . PHE A 1 306 ? -9.764  -33.944 11.114 1.00 48.00  ? 332 PHE A CE2 1 
ATOM   2378 C CZ  . PHE A 1 306 ? -9.263  -32.942 10.303 1.00 52.67  ? 332 PHE A CZ  1 
ATOM   2379 N N   . LEU A 1 307 ? -5.329  -34.481 16.333 1.00 54.14  ? 333 LEU A N   1 
ATOM   2380 C CA  . LEU A 1 307 ? -5.008  -34.361 17.752 1.00 54.27  ? 333 LEU A CA  1 
ATOM   2381 C C   . LEU A 1 307 ? -3.488  -34.389 17.968 1.00 61.43  ? 333 LEU A C   1 
ATOM   2382 O O   . LEU A 1 307 ? -2.947  -35.234 18.668 1.00 56.97  ? 333 LEU A O   1 
ATOM   2383 C CB  . LEU A 1 307 ? -5.704  -35.468 18.534 1.00 53.67  ? 333 LEU A CB  1 
ATOM   2384 C CG  . LEU A 1 307 ? -7.243  -35.368 18.527 1.00 56.30  ? 333 LEU A CG  1 
ATOM   2385 C CD1 . LEU A 1 307 ? -7.897  -36.364 19.457 1.00 54.15  ? 333 LEU A CD1 1 
ATOM   2386 C CD2 . LEU A 1 307 ? -7.660  -33.971 18.888 1.00 56.96  ? 333 LEU A CD2 1 
ATOM   2387 N N   . THR A 1 308 ? -2.790  -33.468 17.307 1.00 58.53  ? 334 THR A N   1 
ATOM   2388 C CA  . THR A 1 308 ? -1.378  -33.211 17.594 1.00 62.43  ? 334 THR A CA  1 
ATOM   2389 C C   . THR A 1 308 ? -1.189  -31.711 17.763 1.00 68.88  ? 334 THR A C   1 
ATOM   2390 O O   . THR A 1 308 ? -2.142  -30.920 17.663 1.00 66.07  ? 334 THR A O   1 
ATOM   2391 C CB  . THR A 1 308 ? -0.442  -33.727 16.493 1.00 61.33  ? 334 THR A CB  1 
ATOM   2392 O OG1 . THR A 1 308 ? -0.783  -33.113 15.248 1.00 57.81  ? 334 THR A OG1 1 
ATOM   2393 C CG2 . THR A 1 308 ? -0.526  -35.236 16.347 1.00 68.59  ? 334 THR A CG2 1 
ATOM   2394 N N   . ASP A 1 309 ? 0.067   -31.317 17.955 1.00 64.57  ? 335 ASP A N   1 
ATOM   2395 C CA  . ASP A 1 309 ? 0.400   -29.907 18.061 1.00 62.26  ? 335 ASP A CA  1 
ATOM   2396 C C   . ASP A 1 309 ? 0.265   -29.223 16.711 1.00 56.87  ? 335 ASP A C   1 
ATOM   2397 O O   . ASP A 1 309 ? 0.403   -29.845 15.658 1.00 62.51  ? 335 ASP A O   1 
ATOM   2398 C CB  . ASP A 1 309 ? 1.828   -29.733 18.613 1.00 64.87  ? 335 ASP A CB  1 
ATOM   2399 C CG  . ASP A 1 309 ? 1.929   -30.134 20.088 1.00 66.23  ? 335 ASP A CG  1 
ATOM   2400 O OD1 . ASP A 1 309 ? 1.208   -29.527 20.914 1.00 69.45  ? 335 ASP A OD1 1 
ATOM   2401 O OD2 . ASP A 1 309 ? 2.705   -31.060 20.427 1.00 71.35  ? 335 ASP A OD2 1 
ATOM   2402 N N   . ARG A 1 310 ? 0.005   -27.914 16.764 1.00 54.11  ? 336 ARG A N   1 
ATOM   2403 C CA  . ARG A 1 310 ? -0.360  -27.136 15.585 1.00 58.04  ? 336 ARG A CA  1 
ATOM   2404 C C   . ARG A 1 310 ? 0.691   -27.174 14.484 1.00 67.30  ? 336 ARG A C   1 
ATOM   2405 O O   . ARG A 1 310 ? 0.349   -27.010 13.296 1.00 57.67  ? 336 ARG A O   1 
ATOM   2406 C CB  . ARG A 1 310 ? -0.595  -25.689 15.992 1.00 61.57  ? 336 ARG A CB  1 
ATOM   2407 C CG  . ARG A 1 310 ? 0.559   -25.160 16.832 1.00 65.89  ? 336 ARG A CG  1 
ATOM   2408 C CD  . ARG A 1 310 ? 0.252   -23.790 17.387 1.00 66.45  ? 336 ARG A CD  1 
ATOM   2409 N NE  . ARG A 1 310 ? -0.115  -22.919 16.293 1.00 73.56  ? 336 ARG A NE  1 
ATOM   2410 C CZ  . ARG A 1 310 ? 0.249   -21.645 16.179 1.00 84.49  ? 336 ARG A CZ  1 
ATOM   2411 N NH1 . ARG A 1 310 ? 0.981   -21.069 17.137 1.00 79.17  ? 336 ARG A NH1 1 
ATOM   2412 N NH2 . ARG A 1 310 ? -0.145  -20.946 15.107 1.00 80.99  ? 336 ARG A NH2 1 
ATOM   2413 N N   . GLU A 1 311 ? 1.976   -27.303 14.852 1.00 61.41  ? 337 GLU A N   1 
ATOM   2414 C CA  . GLU A 1 311 ? 3.040   -27.212 13.851 1.00 60.35  ? 337 GLU A CA  1 
ATOM   2415 C C   . GLU A 1 311 ? 2.961   -28.351 12.863 1.00 54.17  ? 337 GLU A C   1 
ATOM   2416 O O   . GLU A 1 311 ? 3.360   -28.188 11.712 1.00 66.59  ? 337 GLU A O   1 
ATOM   2417 C CB  . GLU A 1 311 ? 4.431   -27.196 14.502 1.00 65.18  ? 337 GLU A CB  1 
ATOM   2418 C CG  . GLU A 1 311 ? 4.485   -26.458 15.804 1.00 72.46  ? 337 GLU A CG  1 
ATOM   2419 C CD  . GLU A 1 311 ? 4.146   -27.346 16.971 1.00 71.00  ? 337 GLU A CD  1 
ATOM   2420 O OE1 . GLU A 1 311 ? 3.218   -26.970 17.710 1.00 74.16  ? 337 GLU A OE1 1 
ATOM   2421 O OE2 . GLU A 1 311 ? 4.810   -28.404 17.147 1.00 76.41  ? 337 GLU A OE2 1 
ATOM   2422 N N   . VAL A 1 312 ? 2.465   -29.515 13.283 1.00 54.57  ? 338 VAL A N   1 
ATOM   2423 C CA  . VAL A 1 312 ? 2.307   -30.627 12.349 1.00 62.97  ? 338 VAL A CA  1 
ATOM   2424 C C   . VAL A 1 312 ? 0.837   -31.064 12.183 1.00 63.97  ? 338 VAL A C   1 
ATOM   2425 O O   . VAL A 1 312 ? 0.582   -32.200 11.811 1.00 59.64  ? 338 VAL A O   1 
ATOM   2426 C CB  . VAL A 1 312 ? 3.181   -31.818 12.774 1.00 65.23  ? 338 VAL A CB  1 
ATOM   2427 C CG1 . VAL A 1 312 ? 4.653   -31.440 12.671 1.00 68.21  ? 338 VAL A CG1 1 
ATOM   2428 C CG2 . VAL A 1 312 ? 2.821   -32.240 14.180 1.00 57.94  ? 338 VAL A CG2 1 
ATOM   2429 N N   . ARG A 1 313 ? -0.142  -30.201 12.474 1.00 55.94  ? 339 ARG A N   1 
ATOM   2430 C CA  . ARG A 1 313 ? -1.541  -30.633 12.462 1.00 60.55  ? 339 ARG A CA  1 
ATOM   2431 C C   . ARG A 1 313 ? -2.110  -30.661 11.044 1.00 47.64  ? 339 ARG A C   1 
ATOM   2432 O O   . ARG A 1 313 ? -1.979  -29.690 10.284 1.00 50.03  ? 339 ARG A O   1 
ATOM   2433 C CB  . ARG A 1 313 ? -2.397  -29.725 13.351 1.00 60.56  ? 339 ARG A CB  1 
ATOM   2434 C CG  . ARG A 1 313 ? -3.776  -30.317 13.694 1.00 55.84  ? 339 ARG A CG  1 
ATOM   2435 C CD  . ARG A 1 313 ? -4.589  -29.389 14.593 1.00 54.94  ? 339 ARG A CD  1 
ATOM   2436 N NE  . ARG A 1 313 ? -3.982  -29.323 15.913 1.00 60.78  ? 339 ARG A NE  1 
ATOM   2437 C CZ  . ARG A 1 313 ? -3.886  -28.216 16.636 1.00 59.55  ? 339 ARG A CZ  1 
ATOM   2438 N NH1 . ARG A 1 313 ? -4.384  -27.083 16.170 1.00 53.42  ? 339 ARG A NH1 1 
ATOM   2439 N NH2 . ARG A 1 313 ? -3.268  -28.241 17.818 1.00 58.55  ? 339 ARG A NH2 1 
ATOM   2440 N N   . LEU A 1 314 ? -2.761  -31.765 10.687 1.00 50.69  ? 340 LEU A N   1 
ATOM   2441 C CA  . LEU A 1 314 ? -3.479  -31.820 9.404  1.00 52.84  ? 340 LEU A CA  1 
ATOM   2442 C C   . LEU A 1 314 ? -4.455  -30.651 9.295  1.00 52.86  ? 340 LEU A C   1 
ATOM   2443 O O   . LEU A 1 314 ? -5.226  -30.375 10.218 1.00 53.47  ? 340 LEU A O   1 
ATOM   2444 C CB  . LEU A 1 314 ? -4.233  -33.142 9.249  1.00 54.65  ? 340 LEU A CB  1 
ATOM   2445 C CG  . LEU A 1 314 ? -4.778  -33.383 7.828  1.00 55.09  ? 340 LEU A CG  1 
ATOM   2446 C CD1 . LEU A 1 314 ? -3.630  -33.583 6.843  1.00 55.57  ? 340 LEU A CD1 1 
ATOM   2447 C CD2 . LEU A 1 314 ? -5.706  -34.587 7.776  1.00 54.52  ? 340 LEU A CD2 1 
ATOM   2448 N N   . GLY A 1 315 ? -4.348  -29.915 8.208  1.00 55.88  ? 341 GLY A N   1 
ATOM   2449 C CA  . GLY A 1 315 ? -5.128  -28.722 8.005  1.00 51.06  ? 341 GLY A CA  1 
ATOM   2450 C C   . GLY A 1 315 ? -4.360  -27.437 8.192  1.00 56.23  ? 341 GLY A C   1 
ATOM   2451 O O   . GLY A 1 315 ? -4.848  -26.388 7.755  1.00 53.37  ? 341 GLY A O   1 
ATOM   2452 N N   . ARG A 1 316 ? -3.146  -27.497 8.771  1.00 59.28  ? 342 ARG A N   1 
ATOM   2453 C CA  . ARG A 1 316 ? -2.339  -26.288 8.939  1.00 59.94  ? 342 ARG A CA  1 
ATOM   2454 C C   . ARG A 1 316 ? -2.126  -25.577 7.611  1.00 52.43  ? 342 ARG A C   1 
ATOM   2455 O O   . ARG A 1 316 ? -2.094  -24.336 7.566  1.00 58.95  ? 342 ARG A O   1 
ATOM   2456 C CB  . ARG A 1 316 ? -0.975  -26.627 9.574  1.00 64.24  ? 342 ARG A CB  1 
ATOM   2457 C CG  . ARG A 1 316 ? -0.160  -27.683 8.808  1.00 67.32  ? 342 ARG A CG  1 
ATOM   2458 C CD  . ARG A 1 316 ? 1.290   -27.968 9.343  1.00 68.08  ? 342 ARG A CD  1 
ATOM   2459 N NE  . ARG A 1 316 ? 1.793   -29.352 9.124  1.00 70.75  ? 342 ARG A NE  1 
ATOM   2460 C CZ  . ARG A 1 316 ? 1.714   -30.077 7.996  1.00 75.33  ? 342 ARG A CZ  1 
ATOM   2461 N NH1 . ARG A 1 316 ? 1.120   -29.607 6.899  1.00 80.10  ? 342 ARG A NH1 1 
ATOM   2462 N NH2 . ARG A 1 316 ? 2.226   -31.308 7.959  1.00 76.47  ? 342 ARG A NH2 1 
ATOM   2463 N N   . ASN A 1 317 ? -2.045  -26.326 6.508  1.00 55.23  ? 343 ASN A N   1 
ATOM   2464 C CA  . ASN A 1 317 ? -1.780  -25.742 5.199  1.00 51.24  ? 343 ASN A CA  1 
ATOM   2465 C C   . ASN A 1 317 ? -3.040  -25.479 4.372  1.00 58.26  ? 343 ASN A C   1 
ATOM   2466 O O   . ASN A 1 317 ? -2.925  -25.005 3.239  1.00 59.41  ? 343 ASN A O   1 
ATOM   2467 C CB  . ASN A 1 317 ? -0.887  -26.666 4.372  1.00 56.00  ? 343 ASN A CB  1 
ATOM   2468 C CG  . ASN A 1 317 ? 0.466   -26.910 5.006  1.00 65.84  ? 343 ASN A CG  1 
ATOM   2469 O OD1 . ASN A 1 317 ? 0.871   -28.063 5.187  1.00 67.55  ? 343 ASN A OD1 1 
ATOM   2470 N ND2 . ASN A 1 317 ? 1.174   -25.834 5.341  1.00 62.73  ? 343 ASN A ND2 1 
ATOM   2471 N N   . GLY A 1 318 ? -4.229  -25.661 4.921  1.00 53.68  ? 344 GLY A N   1 
ATOM   2472 C CA  . GLY A 1 318 ? -5.445  -25.515 4.136  1.00 56.09  ? 344 GLY A CA  1 
ATOM   2473 C C   . GLY A 1 318 ? -6.294  -26.772 4.164  1.00 50.28  ? 344 GLY A C   1 
ATOM   2474 O O   . GLY A 1 318 ? -5.886  -27.825 4.645  1.00 47.53  ? 344 GLY A O   1 
ATOM   2475 N N   . VAL A 1 319 ? -7.541  -26.621 3.694  1.00 64.81  ? 345 VAL A N   1 
ATOM   2476 C CA  . VAL A 1 319 ? -8.449  -27.755 3.846  1.00 50.57  ? 345 VAL A CA  1 
ATOM   2477 C C   . VAL A 1 319 ? -8.299  -28.789 2.735  1.00 51.24  ? 345 VAL A C   1 
ATOM   2478 O O   . VAL A 1 319 ? -8.688  -29.951 2.936  1.00 54.64  ? 345 VAL A O   1 
ATOM   2479 C CB  . VAL A 1 319 ? -9.899  -27.242 3.913  1.00 61.03  ? 345 VAL A CB  1 
ATOM   2480 C CG1 . VAL A 1 319 ? -10.232 -26.416 2.678  1.00 60.92  ? 345 VAL A CG1 1 
ATOM   2481 C CG2 . VAL A 1 319 ? -10.874 -28.395 4.056  1.00 54.14  ? 345 VAL A CG2 1 
ATOM   2482 N N   . GLU A 1 320 ? -7.607  -28.467 1.622  1.00 55.42  ? 346 GLU A N   1 
ATOM   2483 C CA  . GLU A 1 320 ? -7.425  -29.491 0.582  1.00 53.57  ? 346 GLU A CA  1 
ATOM   2484 C C   . GLU A 1 320 ? -6.731  -30.731 1.143  1.00 50.71  ? 346 GLU A C   1 
ATOM   2485 O O   . GLU A 1 320 ? -7.064  -31.861 0.756  1.00 52.80  ? 346 GLU A O   1 
ATOM   2486 C CB  . GLU A 1 320 ? -6.688  -28.922 -0.624 1.00 54.99  ? 346 GLU A CB  1 
ATOM   2487 C CG  . GLU A 1 320 ? -6.261  -29.988 -1.669 1.00 63.13  ? 346 GLU A CG  1 
ATOM   2488 C CD  . GLU A 1 320 ? -7.422  -30.828 -2.251 1.00 71.61  ? 346 GLU A CD  1 
ATOM   2489 O OE1 . GLU A 1 320 ? -7.211  -32.043 -2.545 1.00 64.30  ? 346 GLU A OE1 1 
ATOM   2490 O OE2 . GLU A 1 320 ? -8.534  -30.272 -2.426 1.00 70.82  ? 346 GLU A OE2 1 
ATOM   2491 N N   . GLU A 1 321 ? -5.803  -30.560 2.093  1.00 51.46  ? 347 GLU A N   1 
ATOM   2492 C CA  . GLU A 1 321 ? -5.141  -31.749 2.621  1.00 52.88  ? 347 GLU A CA  1 
ATOM   2493 C C   . GLU A 1 321 ? -6.054  -32.512 3.568  1.00 49.03  ? 347 GLU A C   1 
ATOM   2494 O O   . GLU A 1 321 ? -5.888  -33.726 3.742  1.00 50.46  ? 347 GLU A O   1 
ATOM   2495 C CB  . GLU A 1 321 ? -3.800  -31.386 3.305  1.00 48.54  ? 347 GLU A CB  1 
ATOM   2496 C CG  . GLU A 1 321 ? -3.893  -30.351 4.462  1.00 55.81  ? 347 GLU A CG  1 
ATOM   2497 C CD  . GLU A 1 321 ? -2.524  -29.970 5.081  1.00 64.17  ? 347 GLU A CD  1 
ATOM   2498 O OE1 . GLU A 1 321 ? -1.491  -29.999 4.362  1.00 66.86  ? 347 GLU A OE1 1 
ATOM   2499 O OE2 . GLU A 1 321 ? -2.479  -29.661 6.296  1.00 63.24  ? 347 GLU A OE2 1 
ATOM   2500 N N   . ILE A 1 322 ? -7.034  -31.848 4.176  1.00 52.31  ? 348 ILE A N   1 
ATOM   2501 C CA  . ILE A 1 322 ? -8.012  -32.624 4.924  1.00 48.01  ? 348 ILE A CA  1 
ATOM   2502 C C   . ILE A 1 322 ? -8.868  -33.438 3.964  1.00 43.10  ? 348 ILE A C   1 
ATOM   2503 O O   . ILE A 1 322 ? -9.078  -34.636 4.173  1.00 52.83  ? 348 ILE A O   1 
ATOM   2504 C CB  . ILE A 1 322 ? -8.890  -31.712 5.797  1.00 56.39  ? 348 ILE A CB  1 
ATOM   2505 C CG1 . ILE A 1 322 ? -8.050  -30.921 6.774  1.00 49.41  ? 348 ILE A CG1 1 
ATOM   2506 C CG2 . ILE A 1 322 ? -9.973  -32.526 6.502  1.00 47.25  ? 348 ILE A CG2 1 
ATOM   2507 C CD1 . ILE A 1 322 ? -8.843  -29.860 7.513  1.00 48.74  ? 348 ILE A CD1 1 
ATOM   2508 N N   . ARG A 1 323 ? -9.322  -32.815 2.875  1.00 46.04  ? 349 ARG A N   1 
ATOM   2509 C CA  . ARG A 1 323 ? -10.303 -33.453 1.983  1.00 58.56  ? 349 ARG A CA  1 
ATOM   2510 C C   . ARG A 1 323 ? -9.795  -34.763 1.393  1.00 65.28  ? 349 ARG A C   1 
ATOM   2511 O O   . ARG A 1 323 ? -10.570 -35.723 1.230  1.00 52.49  ? 349 ARG A O   1 
ATOM   2512 C CB  . ARG A 1 323 ? -10.662 -32.521 0.832  1.00 51.66  ? 349 ARG A CB  1 
ATOM   2513 C CG  . ARG A 1 323 ? -11.606 -31.362 1.163  1.00 59.04  ? 349 ARG A CG  1 
ATOM   2514 C CD  . ARG A 1 323 ? -12.101 -30.770 -0.171 1.00 57.70  ? 349 ARG A CD  1 
ATOM   2515 N NE  . ARG A 1 323 ? -12.284 -29.324 -0.095 1.00 63.91  ? 349 ARG A NE  1 
ATOM   2516 C CZ  . ARG A 1 323 ? -11.457 -28.416 -0.608 1.00 61.74  ? 349 ARG A CZ  1 
ATOM   2517 N NH1 . ARG A 1 323 ? -10.372 -28.788 -1.259 1.00 64.89  ? 349 ARG A NH1 1 
ATOM   2518 N NH2 . ARG A 1 323 ? -11.723 -27.125 -0.471 1.00 67.82  ? 349 ARG A NH2 1 
ATOM   2519 N N   . GLN A 1 324 ? -8.505  -34.809 1.012  1.00 58.23  ? 350 GLN A N   1 
ATOM   2520 C CA  . GLN A 1 324 ? -7.984  -35.971 0.287  1.00 52.36  ? 350 GLN A CA  1 
ATOM   2521 C C   . GLN A 1 324 ? -7.686  -37.140 1.202  1.00 52.20  ? 350 GLN A C   1 
ATOM   2522 O O   . GLN A 1 324 ? -7.354  -38.209 0.705  1.00 56.44  ? 350 GLN A O   1 
ATOM   2523 C CB  . GLN A 1 324 ? -6.728  -35.591 -0.520 1.00 54.29  ? 350 GLN A CB  1 
ATOM   2524 C CG  . GLN A 1 324 ? -5.574  -34.971 0.271  1.00 49.87  ? 350 GLN A CG  1 
ATOM   2525 C CD  . GLN A 1 324 ? -4.478  -34.466 -0.660 1.00 61.07  ? 350 GLN A CD  1 
ATOM   2526 O OE1 . GLN A 1 324 ? -4.419  -33.288 -0.998 1.00 66.74  ? 350 GLN A OE1 1 
ATOM   2527 N NE2 . GLN A 1 324 ? -3.660  -35.375 -1.138 1.00 59.92  ? 350 GLN A NE2 1 
ATOM   2528 N N   . HIS A 1 325 ? -7.856  -36.982 2.514  1.00 52.31  ? 351 HIS A N   1 
ATOM   2529 C CA  . HIS A 1 325 ? -7.506  -38.044 3.441  1.00 50.77  ? 351 HIS A CA  1 
ATOM   2530 C C   . HIS A 1 325 ? -8.327  -39.284 3.128  1.00 62.75  ? 351 HIS A C   1 
ATOM   2531 O O   . HIS A 1 325 ? -9.545  -39.178 2.915  1.00 60.83  ? 351 HIS A O   1 
ATOM   2532 C CB  . HIS A 1 325 ? -7.759  -37.629 4.889  1.00 50.40  ? 351 HIS A CB  1 
ATOM   2533 C CG  . HIS A 1 325 ? -7.173  -38.575 5.889  1.00 55.67  ? 351 HIS A CG  1 
ATOM   2534 N ND1 . HIS A 1 325 ? -7.793  -39.751 6.255  1.00 55.64  ? 351 HIS A ND1 1 
ATOM   2535 C CD2 . HIS A 1 325 ? -6.000  -38.539 6.575  1.00 55.03  ? 351 HIS A CD2 1 
ATOM   2536 C CE1 . HIS A 1 325 ? -7.042  -40.391 7.139  1.00 54.68  ? 351 HIS A CE1 1 
ATOM   2537 N NE2 . HIS A 1 325 ? -5.948  -39.674 7.354  1.00 54.90  ? 351 HIS A NE2 1 
ATOM   2538 N N   . PRO A 1 326 ? -7.706  -40.466 3.079  1.00 65.89  ? 352 PRO A N   1 
ATOM   2539 C CA  . PRO A 1 326 ? -8.447  -41.681 2.703  1.00 62.89  ? 352 PRO A CA  1 
ATOM   2540 C C   . PRO A 1 326 ? -9.641  -42.008 3.603  1.00 62.35  ? 352 PRO A C   1 
ATOM   2541 O O   . PRO A 1 326 ? -10.518 -42.766 3.179  1.00 61.93  ? 352 PRO A O   1 
ATOM   2542 C CB  . PRO A 1 326 ? -7.372  -42.778 2.766  1.00 64.59  ? 352 PRO A CB  1 
ATOM   2543 C CG  . PRO A 1 326 ? -6.243  -42.175 3.613  1.00 62.06  ? 352 PRO A CG  1 
ATOM   2544 C CD  . PRO A 1 326 ? -6.264  -40.729 3.248  1.00 60.11  ? 352 PRO A CD  1 
ATOM   2545 N N   . PHE A 1 327 ? -9.709  -41.478 4.825  1.00 63.10  ? 353 PHE A N   1 
ATOM   2546 C CA  . PHE A 1 327 ? -10.885 -41.713 5.655  1.00 55.54  ? 353 PHE A CA  1 
ATOM   2547 C C   . PHE A 1 327 ? -12.162 -41.352 4.914  1.00 54.74  ? 353 PHE A C   1 
ATOM   2548 O O   . PHE A 1 327 ? -13.176 -42.032 5.052  1.00 54.81  ? 353 PHE A O   1 
ATOM   2549 C CB  . PHE A 1 327 ? -10.798 -40.896 6.933  1.00 59.66  ? 353 PHE A CB  1 
ATOM   2550 C CG  . PHE A 1 327 ? -12.007 -41.015 7.804  1.00 59.39  ? 353 PHE A CG  1 
ATOM   2551 C CD1 . PHE A 1 327 ? -12.333 -42.230 8.389  1.00 58.02  ? 353 PHE A CD1 1 
ATOM   2552 C CD2 . PHE A 1 327 ? -12.843 -39.921 8.011  1.00 53.86  ? 353 PHE A CD2 1 
ATOM   2553 C CE1 . PHE A 1 327 ? -13.464 -42.349 9.212  1.00 58.96  ? 353 PHE A CE1 1 
ATOM   2554 C CE2 . PHE A 1 327 ? -13.964 -40.029 8.831  1.00 55.02  ? 353 PHE A CE2 1 
ATOM   2555 C CZ  . PHE A 1 327 ? -14.275 -41.242 9.429  1.00 57.34  ? 353 PHE A CZ  1 
ATOM   2556 N N   . PHE A 1 328 ? -12.105 -40.320 4.083  1.00 53.98  ? 354 PHE A N   1 
ATOM   2557 C CA  . PHE A 1 328 ? -13.244 -39.735 3.407  1.00 57.89  ? 354 PHE A CA  1 
ATOM   2558 C C   . PHE A 1 328 ? -13.645 -40.453 2.124  1.00 65.34  ? 354 PHE A C   1 
ATOM   2559 O O   . PHE A 1 328 ? -14.549 -39.975 1.425  1.00 60.98  ? 354 PHE A O   1 
ATOM   2560 C CB  . PHE A 1 328 ? -12.949 -38.271 3.124  1.00 48.97  ? 354 PHE A CB  1 
ATOM   2561 C CG  . PHE A 1 328 ? -12.944 -37.420 4.376  1.00 59.65  ? 354 PHE A CG  1 
ATOM   2562 C CD1 . PHE A 1 328 ? -14.101 -37.314 5.163  1.00 53.48  ? 354 PHE A CD1 1 
ATOM   2563 C CD2 . PHE A 1 328 ? -11.789 -36.743 4.780  1.00 51.40  ? 354 PHE A CD2 1 
ATOM   2564 C CE1 . PHE A 1 328 ? -14.106 -36.548 6.316  1.00 52.64  ? 354 PHE A CE1 1 
ATOM   2565 C CE2 . PHE A 1 328 ? -11.785 -35.966 5.927  1.00 51.08  ? 354 PHE A CE2 1 
ATOM   2566 C CZ  . PHE A 1 328 ? -12.932 -35.874 6.704  1.00 51.23  ? 354 PHE A CZ  1 
ATOM   2567 N N   . LYS A 1 329 ? -13.010 -41.564 1.780  1.00 60.07  ? 355 LYS A N   1 
ATOM   2568 C CA  . LYS A 1 329 ? -13.432 -42.289 0.598  1.00 66.31  ? 355 LYS A CA  1 
ATOM   2569 C C   . LYS A 1 329 ? -14.753 -42.999 0.892  1.00 60.34  ? 355 LYS A C   1 
ATOM   2570 O O   . LYS A 1 329 ? -14.906 -43.646 1.933  1.00 55.87  ? 355 LYS A O   1 
ATOM   2571 C CB  . LYS A 1 329 ? -12.348 -43.285 0.170  1.00 70.40  ? 355 LYS A CB  1 
ATOM   2572 C CG  . LYS A 1 329 ? -11.446 -42.742 -0.926 1.00 76.66  ? 355 LYS A CG  1 
ATOM   2573 C CD  . LYS A 1 329 ? -12.324 -42.137 -2.017 1.00 84.86  ? 355 LYS A CD  1 
ATOM   2574 C CE  . LYS A 1 329 ? -11.716 -42.249 -3.390 1.00 87.68  ? 355 LYS A CE  1 
ATOM   2575 N NZ  . LYS A 1 329 ? -11.939 -40.961 -4.015 1.00 85.22  ? 355 LYS A NZ  1 
ATOM   2576 N N   . ASN A 1 330 ? -15.703 -42.890 -0.027 1.00 61.61  ? 356 ASN A N   1 
ATOM   2577 C CA  . ASN A 1 330 ? -17.051 -43.364 0.266  1.00 67.41  ? 356 ASN A CA  1 
ATOM   2578 C C   . ASN A 1 330 ? -17.833 -43.426 -1.039 1.00 63.98  ? 356 ASN A C   1 
ATOM   2579 O O   . ASN A 1 330 ? -17.412 -42.879 -2.062 1.00 64.46  ? 356 ASN A O   1 
ATOM   2580 C CB  . ASN A 1 330 ? -17.752 -42.448 1.272  1.00 59.29  ? 356 ASN A CB  1 
ATOM   2581 C CG  . ASN A 1 330 ? -18.226 -41.177 0.626  1.00 62.36  ? 356 ASN A CG  1 
ATOM   2582 O OD1 . ASN A 1 330 ? -19.369 -41.091 0.170  1.00 66.27  ? 356 ASN A OD1 1 
ATOM   2583 N ND2 . ASN A 1 330 ? -17.342 -40.195 0.526  1.00 56.63  ? 356 ASN A ND2 1 
ATOM   2584 N N   . ASP A 1 331 ? -19.015 -44.047 -0.971 1.00 69.61  ? 357 ASP A N   1 
ATOM   2585 C CA  . ASP A 1 331 ? -19.860 -44.279 -2.140 1.00 72.71  ? 357 ASP A CA  1 
ATOM   2586 C C   . ASP A 1 331 ? -21.132 -43.435 -2.141 1.00 73.19  ? 357 ASP A C   1 
ATOM   2587 O O   . ASP A 1 331 ? -22.001 -43.641 -2.995 1.00 72.63  ? 357 ASP A O   1 
ATOM   2588 C CB  . ASP A 1 331 ? -20.253 -45.756 -2.213 1.00 76.65  ? 357 ASP A CB  1 
ATOM   2589 C CG  . ASP A 1 331 ? -19.062 -46.671 -2.289 1.00 83.94  ? 357 ASP A CG  1 
ATOM   2590 O OD1 . ASP A 1 331 ? -18.183 -46.429 -3.158 1.00 83.54  ? 357 ASP A OD1 1 
ATOM   2591 O OD2 . ASP A 1 331 ? -19.017 -47.630 -1.479 1.00 88.60  ? 357 ASP A OD2 1 
ATOM   2592 N N   . GLN A 1 332 ? -21.253 -42.473 -1.232 1.00 67.34  ? 358 GLN A N   1 
ATOM   2593 C CA  . GLN A 1 332 ? -22.482 -41.709 -1.095 1.00 61.01  ? 358 GLN A CA  1 
ATOM   2594 C C   . GLN A 1 332 ? -22.371 -40.253 -1.515 1.00 63.56  ? 358 GLN A C   1 
ATOM   2595 O O   . GLN A 1 332 ? -23.374 -39.679 -1.955 1.00 63.77  ? 358 GLN A O   1 
ATOM   2596 C CB  . GLN A 1 332 ? -22.952 -41.750 0.372  1.00 61.04  ? 358 GLN A CB  1 
ATOM   2597 C CG  . GLN A 1 332 ? -23.422 -43.114 0.892  1.00 65.46  ? 358 GLN A CG  1 
ATOM   2598 C CD  . GLN A 1 332 ? -22.306 -43.996 1.465  1.00 75.49  ? 358 GLN A CD  1 
ATOM   2599 O OE1 . GLN A 1 332 ? -21.573 -43.608 2.396  1.00 70.48  ? 358 GLN A OE1 1 
ATOM   2600 N NE2 . GLN A 1 332 ? -22.178 -45.202 0.909  1.00 75.47  ? 358 GLN A NE2 1 
ATOM   2601 N N   . TRP A 1 333 ? -21.193 -39.629 -1.407 1.00 59.69  ? 359 TRP A N   1 
ATOM   2602 C CA  . TRP A 1 333 ? -21.123 -38.183 -1.587 1.00 53.78  ? 359 TRP A CA  1 
ATOM   2603 C C   . TRP A 1 333 ? -19.732 -37.762 -2.033 1.00 58.95  ? 359 TRP A C   1 
ATOM   2604 O O   . TRP A 1 333 ? -18.742 -38.462 -1.815 1.00 57.61  ? 359 TRP A O   1 
ATOM   2605 C CB  . TRP A 1 333 ? -21.511 -37.449 -0.279 1.00 47.75  ? 359 TRP A CB  1 
ATOM   2606 C CG  . TRP A 1 333 ? -20.717 -37.888 0.910  1.00 55.26  ? 359 TRP A CG  1 
ATOM   2607 C CD1 . TRP A 1 333 ? -21.097 -38.795 1.864  1.00 58.01  ? 359 TRP A CD1 1 
ATOM   2608 C CD2 . TRP A 1 333 ? -19.414 -37.421 1.298  1.00 51.99  ? 359 TRP A CD2 1 
ATOM   2609 N NE1 . TRP A 1 333 ? -20.103 -38.938 2.806  1.00 55.59  ? 359 TRP A NE1 1 
ATOM   2610 C CE2 . TRP A 1 333 ? -19.064 -38.101 2.488  1.00 56.21  ? 359 TRP A CE2 1 
ATOM   2611 C CE3 . TRP A 1 333 ? -18.505 -36.508 0.747  1.00 54.80  ? 359 TRP A CE3 1 
ATOM   2612 C CZ2 . TRP A 1 333 ? -17.837 -37.905 3.133  1.00 51.76  ? 359 TRP A CZ2 1 
ATOM   2613 C CZ3 . TRP A 1 333 ? -17.265 -36.323 1.387  1.00 54.01  ? 359 TRP A CZ3 1 
ATOM   2614 C CH2 . TRP A 1 333 ? -16.956 -37.014 2.571  1.00 54.07  ? 359 TRP A CH2 1 
ATOM   2615 N N   . HIS A 1 334 ? -19.672 -36.587 -2.635 1.00 57.70  ? 360 HIS A N   1 
ATOM   2616 C CA  . HIS A 1 334 ? -18.437 -35.895 -2.955 1.00 59.15  ? 360 HIS A CA  1 
ATOM   2617 C C   . HIS A 1 334 ? -18.384 -34.585 -2.183 1.00 63.10  ? 360 HIS A C   1 
ATOM   2618 O O   . HIS A 1 334 ? -19.418 -34.068 -1.742 1.00 56.88  ? 360 HIS A O   1 
ATOM   2619 C CB  . HIS A 1 334 ? -18.341 -35.643 -4.468 1.00 62.25  ? 360 HIS A CB  1 
ATOM   2620 C CG  . HIS A 1 334 ? -18.453 -36.896 -5.282 1.00 68.02  ? 360 HIS A CG  1 
ATOM   2621 N ND1 . HIS A 1 334 ? -17.506 -37.899 -5.236 1.00 71.19  ? 360 HIS A ND1 1 
ATOM   2622 C CD2 . HIS A 1 334 ? -19.422 -37.333 -6.122 1.00 67.28  ? 360 HIS A CD2 1 
ATOM   2623 C CE1 . HIS A 1 334 ? -17.879 -38.891 -6.028 1.00 68.38  ? 360 HIS A CE1 1 
ATOM   2624 N NE2 . HIS A 1 334 ? -19.037 -38.571 -6.576 1.00 69.98  ? 360 HIS A NE2 1 
ATOM   2625 N N   . TRP A 1 335 ? -17.167 -34.037 -2.038 1.00 57.80  ? 361 TRP A N   1 
ATOM   2626 C CA  . TRP A 1 335 ? -16.987 -32.764 -1.336 1.00 56.57  ? 361 TRP A CA  1 
ATOM   2627 C C   . TRP A 1 335 ? -17.813 -31.667 -1.988 1.00 60.25  ? 361 TRP A C   1 
ATOM   2628 O O   . TRP A 1 335 ? -18.178 -30.687 -1.329 1.00 60.32  ? 361 TRP A O   1 
ATOM   2629 C CB  . TRP A 1 335 ? -15.489 -32.378 -1.295 1.00 56.52  ? 361 TRP A CB  1 
ATOM   2630 C CG  . TRP A 1 335 ? -14.756 -33.229 -0.290 1.00 51.86  ? 361 TRP A CG  1 
ATOM   2631 C CD1 . TRP A 1 335 ? -14.067 -34.397 -0.538 1.00 55.94  ? 361 TRP A CD1 1 
ATOM   2632 C CD2 . TRP A 1 335 ? -14.719 -33.040 1.132  1.00 50.84  ? 361 TRP A CD2 1 
ATOM   2633 N NE1 . TRP A 1 335 ? -13.590 -34.928 0.647  1.00 53.56  ? 361 TRP A NE1 1 
ATOM   2634 C CE2 . TRP A 1 335 ? -13.967 -34.109 1.680  1.00 51.45  ? 361 TRP A CE2 1 
ATOM   2635 C CE3 . TRP A 1 335 ? -15.247 -32.071 1.998  1.00 51.85  ? 361 TRP A CE3 1 
ATOM   2636 C CZ2 . TRP A 1 335 ? -13.726 -34.226 3.039  1.00 57.05  ? 361 TRP A CZ2 1 
ATOM   2637 C CZ3 . TRP A 1 335 ? -14.991 -32.188 3.361  1.00 53.49  ? 361 TRP A CZ3 1 
ATOM   2638 C CH2 . TRP A 1 335 ? -14.246 -33.257 3.862  1.00 54.86  ? 361 TRP A CH2 1 
ATOM   2639 N N   . ASP A 1 336 ? -18.114 -31.848 -3.268 1.00 55.16  ? 362 ASP A N   1 
ATOM   2640 C CA  . ASP A 1 336 ? -18.801 -30.915 -4.136 1.00 63.81  ? 362 ASP A CA  1 
ATOM   2641 C C   . ASP A 1 336 ? -20.312 -30.919 -3.954 1.00 59.09  ? 362 ASP A C   1 
ATOM   2642 O O   . ASP A 1 336 ? -20.955 -29.911 -4.240 1.00 57.68  ? 362 ASP A O   1 
ATOM   2643 C CB  . ASP A 1 336 ? -18.522 -31.347 -5.589 1.00 59.70  ? 362 ASP A CB  1 
ATOM   2644 C CG  . ASP A 1 336 ? -18.033 -30.241 -6.435 1.00 81.87  ? 362 ASP A CG  1 
ATOM   2645 O OD1 . ASP A 1 336 ? -18.015 -29.095 -5.933 1.00 85.07  ? 362 ASP A OD1 1 
ATOM   2646 O OD2 . ASP A 1 336 ? -17.661 -30.523 -7.598 1.00 92.73  ? 362 ASP A OD2 1 
ATOM   2647 N N   . ASN A 1 337 ? -20.876 -32.001 -3.428 1.00 55.41  ? 363 ASN A N   1 
ATOM   2648 C CA  . ASN A 1 337 ? -22.322 -32.163 -3.475 1.00 64.61  ? 363 ASN A CA  1 
ATOM   2649 C C   . ASN A 1 337 ? -22.891 -32.700 -2.172 1.00 62.98  ? 363 ASN A C   1 
ATOM   2650 O O   . ASN A 1 337 ? -24.070 -33.089 -2.147 1.00 61.15  ? 363 ASN A O   1 
ATOM   2651 C CB  . ASN A 1 337 ? -22.704 -33.096 -4.650 1.00 53.87  ? 363 ASN A CB  1 
ATOM   2652 C CG  . ASN A 1 337 ? -22.505 -34.566 -4.322 1.00 55.32  ? 363 ASN A CG  1 
ATOM   2653 O OD1 . ASN A 1 337 ? -21.854 -34.913 -3.342 1.00 56.31  ? 363 ASN A OD1 1 
ATOM   2654 N ND2 . ASN A 1 337 ? -23.073 -35.445 -5.148 1.00 61.54  ? 363 ASN A ND2 1 
ATOM   2655 N N   . ILE A 1 338 ? -22.093 -32.733 -1.097 1.00 50.13  ? 364 ILE A N   1 
ATOM   2656 C CA  . ILE A 1 338 ? -22.464 -33.520 0.058  1.00 53.73  ? 364 ILE A CA  1 
ATOM   2657 C C   . ILE A 1 338 ? -23.766 -33.002 0.661  1.00 56.59  ? 364 ILE A C   1 
ATOM   2658 O O   . ILE A 1 338 ? -24.600 -33.790 1.117  1.00 53.11  ? 364 ILE A O   1 
ATOM   2659 C CB  . ILE A 1 338 ? -21.322 -33.545 1.090  1.00 53.23  ? 364 ILE A CB  1 
ATOM   2660 C CG1 . ILE A 1 338 ? -21.681 -34.470 2.227  1.00 48.13  ? 364 ILE A CG1 1 
ATOM   2661 C CG2 . ILE A 1 338 ? -21.041 -32.165 1.660  1.00 49.05  ? 364 ILE A CG2 1 
ATOM   2662 C CD1 . ILE A 1 338 ? -20.627 -34.496 3.304  1.00 52.61  ? 364 ILE A CD1 1 
ATOM   2663 N N   . ARG A 1 339 ? -23.974 -31.679 0.647  1.00 51.26  ? 365 ARG A N   1 
ATOM   2664 C CA  . ARG A 1 339 ? -25.179 -31.131 1.242  1.00 62.73  ? 365 ARG A CA  1 
ATOM   2665 C C   . ARG A 1 339 ? -26.406 -31.340 0.376  1.00 60.31  ? 365 ARG A C   1 
ATOM   2666 O O   . ARG A 1 339 ? -27.506 -30.983 0.805  1.00 58.10  ? 365 ARG A O   1 
ATOM   2667 C CB  . ARG A 1 339 ? -25.020 -29.636 1.561  1.00 59.05  ? 365 ARG A CB  1 
ATOM   2668 C CG  . ARG A 1 339 ? -25.514 -29.339 3.004  1.00 56.56  ? 365 ARG A CG  1 
ATOM   2669 C CD  . ARG A 1 339 ? -25.609 -27.858 3.332  1.00 54.76  ? 365 ARG A CD  1 
ATOM   2670 N NE  . ARG A 1 339 ? -26.041 -27.666 4.726  1.00 57.92  ? 365 ARG A NE  1 
ATOM   2671 C CZ  . ARG A 1 339 ? -27.325 -27.562 5.080  1.00 59.03  ? 365 ARG A CZ  1 
ATOM   2672 N NH1 . ARG A 1 339 ? -28.282 -27.615 4.149  1.00 51.66  ? 365 ARG A NH1 1 
ATOM   2673 N NH2 . ARG A 1 339 ? -27.648 -27.394 6.345  1.00 52.16  ? 365 ARG A NH2 1 
ATOM   2674 N N   . GLU A 1 340 ? -26.230 -31.880 -0.830 1.00 61.71  ? 366 GLU A N   1 
ATOM   2675 C CA  . GLU A 1 340 ? -27.323 -32.238 -1.716 1.00 57.83  ? 366 GLU A CA  1 
ATOM   2676 C C   . GLU A 1 340 ? -27.546 -33.732 -1.767 1.00 55.69  ? 366 GLU A C   1 
ATOM   2677 O O   . GLU A 1 340 ? -28.228 -34.211 -2.666 1.00 57.67  ? 366 GLU A O   1 
ATOM   2678 C CB  . GLU A 1 340 ? -27.090 -31.685 -3.110 1.00 53.13  ? 366 GLU A CB  1 
ATOM   2679 C CG  . GLU A 1 340 ? -27.044 -30.179 -3.093 1.00 63.48  ? 366 GLU A CG  1 
ATOM   2680 C CD  . GLU A 1 340 ? -25.632 -29.638 -3.237 1.00 79.33  ? 366 GLU A CD  1 
ATOM   2681 O OE1 . GLU A 1 340 ? -25.025 -29.876 -4.308 1.00 82.78  ? 366 GLU A OE1 1 
ATOM   2682 O OE2 . GLU A 1 340 ? -25.132 -28.981 -2.285 1.00 77.69  ? 366 GLU A OE2 1 
ATOM   2683 N N   . THR A 1 341 ? -26.937 -34.487 -0.870 1.00 51.02  ? 367 THR A N   1 
ATOM   2684 C CA  . THR A 1 341 ? -27.136 -35.922 -0.843 1.00 53.04  ? 367 THR A CA  1 
ATOM   2685 C C   . THR A 1 341 ? -27.987 -36.252 0.366  1.00 55.17  ? 367 THR A C   1 
ATOM   2686 O O   . THR A 1 341 ? -28.212 -35.409 1.238  1.00 59.28  ? 367 THR A O   1 
ATOM   2687 C CB  . THR A 1 341 ? -25.795 -36.677 -0.801 1.00 57.02  ? 367 THR A CB  1 
ATOM   2688 O OG1 . THR A 1 341 ? -25.096 -36.363 0.421  1.00 54.19  ? 367 THR A OG1 1 
ATOM   2689 C CG2 . THR A 1 341 ? -24.935 -36.273 -1.975 1.00 54.60  ? 367 THR A CG2 1 
ATOM   2690 N N   . ALA A 1 342 ? -28.401 -37.509 0.451  1.00 55.56  ? 368 ALA A N   1 
ATOM   2691 C CA  . ALA A 1 342 ? -29.245 -37.938 1.555  1.00 61.06  ? 368 ALA A CA  1 
ATOM   2692 C C   . ALA A 1 342 ? -28.428 -37.992 2.839  1.00 60.63  ? 368 ALA A C   1 
ATOM   2693 O O   . ALA A 1 342 ? -27.419 -38.695 2.906  1.00 55.61  ? 368 ALA A O   1 
ATOM   2694 C CB  . ALA A 1 342 ? -29.847 -39.307 1.246  1.00 49.38  ? 368 ALA A CB  1 
ATOM   2695 N N   . ALA A 1 343 ? -28.889 -37.301 3.881  1.00 56.53  ? 369 ALA A N   1 
ATOM   2696 C CA  . ALA A 1 343 ? -28.194 -37.357 5.149  1.00 53.66  ? 369 ALA A CA  1 
ATOM   2697 C C   . ALA A 1 343 ? -28.363 -38.743 5.768  1.00 56.77  ? 369 ALA A C   1 
ATOM   2698 O O   . ALA A 1 343 ? -29.286 -39.471 5.421  1.00 60.05  ? 369 ALA A O   1 
ATOM   2699 C CB  . ALA A 1 343 ? -28.718 -36.281 6.091  1.00 54.10  ? 369 ALA A CB  1 
ATOM   2700 N N   . PRO A 1 344 ? -27.453 -39.141 6.667  1.00 51.28  ? 370 PRO A N   1 
ATOM   2701 C CA  . PRO A 1 344 ? -27.576 -40.462 7.318  1.00 55.57  ? 370 PRO A CA  1 
ATOM   2702 C C   . PRO A 1 344 ? -28.839 -40.632 8.168  1.00 61.46  ? 370 PRO A C   1 
ATOM   2703 O O   . PRO A 1 344 ? -29.400 -41.732 8.220  1.00 61.20  ? 370 PRO A O   1 
ATOM   2704 C CB  . PRO A 1 344 ? -26.309 -40.538 8.193  1.00 57.54  ? 370 PRO A CB  1 
ATOM   2705 C CG  . PRO A 1 344 ? -25.336 -39.561 7.537  1.00 56.96  ? 370 PRO A CG  1 
ATOM   2706 C CD  . PRO A 1 344 ? -26.220 -38.443 7.063  1.00 57.38  ? 370 PRO A CD  1 
ATOM   2707 N N   . VAL A 1 345 ? -29.236 -39.610 8.920  1.00 53.53  ? 371 VAL A N   1 
ATOM   2708 C CA  . VAL A 1 345 ? -30.450 -39.646 9.734  1.00 61.08  ? 371 VAL A CA  1 
ATOM   2709 C C   . VAL A 1 345 ? -31.311 -38.504 9.223  1.00 59.79  ? 371 VAL A C   1 
ATOM   2710 O O   . VAL A 1 345 ? -30.974 -37.328 9.416  1.00 59.41  ? 371 VAL A O   1 
ATOM   2711 C CB  . VAL A 1 345 ? -30.168 -39.496 11.242 1.00 61.54  ? 371 VAL A CB  1 
ATOM   2712 C CG1 . VAL A 1 345 ? -31.496 -39.399 12.070 1.00 64.90  ? 371 VAL A CG1 1 
ATOM   2713 C CG2 . VAL A 1 345 ? -29.252 -40.623 11.776 1.00 59.61  ? 371 VAL A CG2 1 
ATOM   2714 N N   . VAL A 1 346 ? -32.418 -38.833 8.573  1.00 58.85  ? 372 VAL A N   1 
ATOM   2715 C CA  . VAL A 1 346 ? -33.422 -37.840 8.201  1.00 59.99  ? 372 VAL A CA  1 
ATOM   2716 C C   . VAL A 1 346 ? -34.438 -37.817 9.328  1.00 60.12  ? 372 VAL A C   1 
ATOM   2717 O O   . VAL A 1 346 ? -34.949 -38.883 9.705  1.00 61.31  ? 372 VAL A O   1 
ATOM   2718 C CB  . VAL A 1 346 ? -34.090 -38.166 6.859  1.00 62.80  ? 372 VAL A CB  1 
ATOM   2719 C CG1 . VAL A 1 346 ? -35.041 -37.039 6.454  1.00 65.39  ? 372 VAL A CG1 1 
ATOM   2720 C CG2 . VAL A 1 346 ? -33.054 -38.382 5.801  1.00 64.11  ? 372 VAL A CG2 1 
ATOM   2721 N N   . PRO A 1 347 ? -34.683 -36.671 9.968  1.00 59.76  ? 373 PRO A N   1 
ATOM   2722 C CA  . PRO A 1 347 ? -35.602 -36.656 11.110 1.00 64.53  ? 373 PRO A CA  1 
ATOM   2723 C C   . PRO A 1 347 ? -37.049 -36.850 10.662 1.00 67.51  ? 373 PRO A C   1 
ATOM   2724 O O   . PRO A 1 347 ? -37.485 -36.322 9.634  1.00 62.87  ? 373 PRO A O   1 
ATOM   2725 C CB  . PRO A 1 347 ? -35.372 -35.271 11.735 1.00 63.03  ? 373 PRO A CB  1 
ATOM   2726 C CG  . PRO A 1 347 ? -34.912 -34.437 10.622 1.00 60.55  ? 373 PRO A CG  1 
ATOM   2727 C CD  . PRO A 1 347 ? -34.111 -35.337 9.703  1.00 58.59  ? 373 PRO A CD  1 
ATOM   2728 N N   . GLU A 1 348 ? -37.779 -37.652 11.431 1.00 70.60  ? 374 GLU A N   1 
ATOM   2729 C CA  . GLU A 1 348 ? -39.214 -37.813 11.238 1.00 72.18  ? 374 GLU A CA  1 
ATOM   2730 C C   . GLU A 1 348 ? -39.887 -36.754 12.103 1.00 66.10  ? 374 GLU A C   1 
ATOM   2731 O O   . GLU A 1 348 ? -39.771 -36.781 13.333 1.00 67.56  ? 374 GLU A O   1 
ATOM   2732 C CB  . GLU A 1 348 ? -39.655 -39.224 11.619 1.00 75.45  ? 374 GLU A CB  1 
ATOM   2733 N N   . LEU A 1 349 ? -40.550 -35.800 11.460 1.00 63.77  ? 375 LEU A N   1 
ATOM   2734 C CA  . LEU A 1 349 ? -41.100 -34.645 12.149 1.00 67.57  ? 375 LEU A CA  1 
ATOM   2735 C C   . LEU A 1 349 ? -42.615 -34.676 12.017 1.00 70.00  ? 375 LEU A C   1 
ATOM   2736 O O   . LEU A 1 349 ? -43.140 -34.698 10.897 1.00 60.77  ? 375 LEU A O   1 
ATOM   2737 C CB  . LEU A 1 349 ? -40.546 -33.338 11.566 1.00 63.35  ? 375 LEU A CB  1 
ATOM   2738 C CG  . LEU A 1 349 ? -39.025 -33.141 11.726 1.00 67.31  ? 375 LEU A CG  1 
ATOM   2739 C CD1 . LEU A 1 349 ? -38.539 -31.911 10.933 1.00 56.42  ? 375 LEU A CD1 1 
ATOM   2740 C CD2 . LEU A 1 349 ? -38.658 -33.059 13.207 1.00 61.19  ? 375 LEU A CD2 1 
ATOM   2741 N N   . SER A 1 350 ? -43.294 -34.597 13.166 1.00 69.60  ? 376 SER A N   1 
ATOM   2742 C CA  . SER A 1 350 ? -44.743 -34.711 13.296 1.00 74.60  ? 376 SER A CA  1 
ATOM   2743 C C   . SER A 1 350 ? -45.468 -33.375 13.228 1.00 73.84  ? 376 SER A C   1 
ATOM   2744 O O   . SER A 1 350 ? -46.694 -33.370 13.138 1.00 79.82  ? 376 SER A O   1 
ATOM   2745 C CB  . SER A 1 350 ? -45.110 -35.412 14.615 1.00 68.04  ? 376 SER A CB  1 
ATOM   2746 O OG  . SER A 1 350 ? -44.733 -34.643 15.752 1.00 77.36  ? 376 SER A OG  1 
ATOM   2747 N N   . SER A 1 351 ? -44.754 -32.255 13.306 1.00 71.09  ? 377 SER A N   1 
ATOM   2748 C CA  . SER A 1 351 ? -45.355 -30.935 13.445 1.00 64.08  ? 377 SER A CA  1 
ATOM   2749 C C   . SER A 1 351 ? -44.290 -29.906 13.092 1.00 71.68  ? 377 SER A C   1 
ATOM   2750 O O   . SER A 1 351 ? -43.100 -30.224 13.059 1.00 69.43  ? 377 SER A O   1 
ATOM   2751 C CB  . SER A 1 351 ? -45.876 -30.734 14.865 1.00 66.64  ? 377 SER A CB  1 
ATOM   2752 O OG  . SER A 1 351 ? -45.791 -29.381 15.261 1.00 68.46  ? 377 SER A OG  1 
ATOM   2753 N N   . ASP A 1 352 ? -44.714 -28.670 12.820 1.00 65.59  ? 378 ASP A N   1 
ATOM   2754 C CA  . ASP A 1 352 ? -43.725 -27.612 12.618 1.00 62.47  ? 378 ASP A CA  1 
ATOM   2755 C C   . ASP A 1 352 ? -43.110 -27.088 13.919 1.00 65.85  ? 378 ASP A C   1 
ATOM   2756 O O   . ASP A 1 352 ? -42.218 -26.236 13.848 1.00 67.61  ? 378 ASP A O   1 
ATOM   2757 C CB  . ASP A 1 352 ? -44.321 -26.465 11.800 1.00 63.70  ? 378 ASP A CB  1 
ATOM   2758 C CG  . ASP A 1 352 ? -45.499 -25.784 12.495 1.00 70.21  ? 378 ASP A CG  1 
ATOM   2759 O OD1 . ASP A 1 352 ? -45.859 -26.200 13.622 1.00 65.08  ? 378 ASP A OD1 1 
ATOM   2760 O OD2 . ASP A 1 352 ? -46.060 -24.821 11.907 1.00 71.65  ? 378 ASP A OD2 1 
ATOM   2761 N N   . ILE A 1 353 ? -43.567 -27.568 15.082 1.00 62.82  ? 379 ILE A N   1 
ATOM   2762 C CA  . ILE A 1 353 ? -43.027 -27.287 16.407 1.00 64.85  ? 379 ILE A CA  1 
ATOM   2763 C C   . ILE A 1 353 ? -42.607 -28.581 17.097 1.00 61.75  ? 379 ILE A C   1 
ATOM   2764 O O   . ILE A 1 353 ? -42.485 -28.636 18.327 1.00 64.32  ? 379 ILE A O   1 
ATOM   2765 C CB  . ILE A 1 353 ? -44.006 -26.481 17.296 1.00 68.40  ? 379 ILE A CB  1 
ATOM   2766 C CG1 . ILE A 1 353 ? -45.356 -27.200 17.470 1.00 72.25  ? 379 ILE A CG1 1 
ATOM   2767 C CG2 . ILE A 1 353 ? -44.201 -25.072 16.766 1.00 66.92  ? 379 ILE A CG2 1 
ATOM   2768 C CD1 . ILE A 1 353 ? -45.533 -27.897 18.829 1.00 71.45  ? 379 ILE A CD1 1 
ATOM   2769 N N   . ASP A 1 354 ? -42.449 -29.642 16.318 1.00 59.67  ? 380 ASP A N   1 
ATOM   2770 C CA  . ASP A 1 354 ? -41.901 -30.882 16.852 1.00 63.60  ? 380 ASP A CA  1 
ATOM   2771 C C   . ASP A 1 354 ? -40.533 -30.599 17.458 1.00 64.84  ? 380 ASP A C   1 
ATOM   2772 O O   . ASP A 1 354 ? -39.635 -30.097 16.766 1.00 60.90  ? 380 ASP A O   1 
ATOM   2773 C CB  . ASP A 1 354 ? -41.792 -31.921 15.732 1.00 65.43  ? 380 ASP A CB  1 
ATOM   2774 C CG  . ASP A 1 354 ? -41.394 -33.299 16.235 1.00 66.36  ? 380 ASP A CG  1 
ATOM   2775 O OD1 . ASP A 1 354 ? -40.804 -33.403 17.342 1.00 73.90  ? 380 ASP A OD1 1 
ATOM   2776 O OD2 . ASP A 1 354 ? -41.666 -34.289 15.507 1.00 66.60  ? 380 ASP A OD2 1 
ATOM   2777 N N   . SER A 1 355 ? -40.397 -30.887 18.756 1.00 60.65  ? 381 SER A N   1 
ATOM   2778 C CA  . SER A 1 355 ? -39.157 -30.701 19.497 1.00 63.12  ? 381 SER A CA  1 
ATOM   2779 C C   . SER A 1 355 ? -38.641 -32.010 20.079 1.00 61.46  ? 381 SER A C   1 
ATOM   2780 O O   . SER A 1 355 ? -37.896 -31.999 21.064 1.00 62.66  ? 381 SER A O   1 
ATOM   2781 C CB  . SER A 1 355 ? -39.354 -29.666 20.607 1.00 68.85  ? 381 SER A CB  1 
ATOM   2782 O OG  . SER A 1 355 ? -40.402 -30.066 21.483 1.00 71.18  ? 381 SER A OG  1 
ATOM   2783 N N   . SER A 1 356 ? -39.030 -33.144 19.497 1.00 62.65  ? 382 SER A N   1 
ATOM   2784 C CA  . SER A 1 356 ? -38.626 -34.446 20.029 1.00 61.67  ? 382 SER A CA  1 
ATOM   2785 C C   . SER A 1 356 ? -37.116 -34.696 19.959 1.00 65.04  ? 382 SER A C   1 
ATOM   2786 O O   . SER A 1 356 ? -36.627 -35.616 20.624 1.00 64.40  ? 382 SER A O   1 
ATOM   2787 C CB  . SER A 1 356 ? -39.333 -35.541 19.259 1.00 61.10  ? 382 SER A CB  1 
ATOM   2788 O OG  . SER A 1 356 ? -39.352 -35.173 17.896 1.00 68.26  ? 382 SER A OG  1 
ATOM   2789 N N   . ASN A 1 357 ? -36.370 -33.955 19.139 1.00 60.26  ? 383 ASN A N   1 
ATOM   2790 C CA  . ASN A 1 357 ? -34.919 -34.150 19.095 1.00 62.29  ? 383 ASN A CA  1 
ATOM   2791 C C   . ASN A 1 357 ? -34.173 -33.277 20.107 1.00 65.00  ? 383 ASN A C   1 
ATOM   2792 O O   . ASN A 1 357 ? -32.940 -33.196 20.052 1.00 61.64  ? 383 ASN A O   1 
ATOM   2793 C CB  . ASN A 1 357 ? -34.395 -33.902 17.674 1.00 56.50  ? 383 ASN A CB  1 
ATOM   2794 C CG  . ASN A 1 357 ? -34.987 -34.865 16.662 1.00 55.96  ? 383 ASN A CG  1 
ATOM   2795 O OD1 . ASN A 1 357 ? -34.955 -36.083 16.845 1.00 61.46  ? 383 ASN A OD1 1 
ATOM   2796 N ND2 . ASN A 1 357 ? -35.544 -34.322 15.597 1.00 60.11  ? 383 ASN A ND2 1 
ATOM   2797 N N   . PHE A 1 358 ? -34.886 -32.668 21.056 1.00 67.94  ? 384 PHE A N   1 
ATOM   2798 C CA  . PHE A 1 358 ? -34.305 -31.826 22.095 1.00 67.73  ? 384 PHE A CA  1 
ATOM   2799 C C   . PHE A 1 358 ? -34.794 -32.282 23.461 1.00 75.32  ? 384 PHE A C   1 
ATOM   2800 O O   . PHE A 1 358 ? -36.005 -32.413 23.674 1.00 73.22  ? 384 PHE A O   1 
ATOM   2801 C CB  . PHE A 1 358 ? -34.680 -30.358 21.884 1.00 62.03  ? 384 PHE A CB  1 
ATOM   2802 C CG  . PHE A 1 358 ? -34.084 -29.755 20.646 1.00 67.92  ? 384 PHE A CG  1 
ATOM   2803 C CD1 . PHE A 1 358 ? -32.774 -29.280 20.655 1.00 62.54  ? 384 PHE A CD1 1 
ATOM   2804 C CD2 . PHE A 1 358 ? -34.830 -29.672 19.467 1.00 53.92  ? 384 PHE A CD2 1 
ATOM   2805 C CE1 . PHE A 1 358 ? -32.220 -28.713 19.502 1.00 58.25  ? 384 PHE A CE1 1 
ATOM   2806 C CE2 . PHE A 1 358 ? -34.308 -29.104 18.326 1.00 54.05  ? 384 PHE A CE2 1 
ATOM   2807 C CZ  . PHE A 1 358 ? -32.989 -28.620 18.331 1.00 57.74  ? 384 PHE A CZ  1 
ATOM   2808 N N   . ASP A 1 359 ? -33.862 -32.488 24.390 1.00 78.12  ? 385 ASP A N   1 
ATOM   2809 C CA  . ASP A 1 359 ? -34.240 -32.849 25.748 1.00 83.41  ? 385 ASP A CA  1 
ATOM   2810 C C   . ASP A 1 359 ? -34.984 -31.699 26.426 1.00 86.86  ? 385 ASP A C   1 
ATOM   2811 O O   . ASP A 1 359 ? -34.842 -30.530 26.057 1.00 88.91  ? 385 ASP A O   1 
ATOM   2812 C CB  . ASP A 1 359 ? -33.004 -33.222 26.561 1.00 83.71  ? 385 ASP A CB  1 
ATOM   2813 C CG  . ASP A 1 359 ? -32.140 -34.244 25.859 1.00 91.97  ? 385 ASP A CG  1 
ATOM   2814 O OD1 . ASP A 1 359 ? -32.703 -35.154 25.206 1.00 96.81  ? 385 ASP A OD1 1 
ATOM   2815 O OD2 . ASP A 1 359 ? -30.899 -34.133 25.950 1.00 92.67  ? 385 ASP A OD2 1 
ATOM   2816 N N   . ASP A 1 360 ? -35.819 -32.046 27.400 1.00 89.62  ? 386 ASP A N   1 
ATOM   2817 C CA  . ASP A 1 360 ? -36.464 -31.034 28.225 1.00 94.48  ? 386 ASP A CA  1 
ATOM   2818 C C   . ASP A 1 360 ? -35.432 -30.340 29.108 1.00 93.29  ? 386 ASP A C   1 
ATOM   2819 O O   . ASP A 1 360 ? -34.379 -30.902 29.432 1.00 90.85  ? 386 ASP A O   1 
ATOM   2820 C CB  . ASP A 1 360 ? -37.542 -31.669 29.100 1.00 93.27  ? 386 ASP A CB  1 
ATOM   2821 C CG  . ASP A 1 360 ? -38.415 -32.655 28.333 1.00 100.23 ? 386 ASP A CG  1 
ATOM   2822 O OD1 . ASP A 1 360 ? -39.196 -33.388 28.984 1.00 106.35 ? 386 ASP A OD1 1 
ATOM   2823 O OD2 . ASP A 1 360 ? -38.331 -32.694 27.085 1.00 104.31 ? 386 ASP A OD2 1 
ATOM   2824 N N   . ILE A 1 361 ? -35.728 -29.098 29.490 1.00 96.78  ? 387 ILE A N   1 
ATOM   2825 C CA  . ILE A 1 361 ? -34.895 -28.367 30.443 1.00 99.27  ? 387 ILE A CA  1 
ATOM   2826 C C   . ILE A 1 361 ? -35.807 -27.646 31.436 1.00 103.83 ? 387 ILE A C   1 
ATOM   2827 O O   . ILE A 1 361 ? -36.824 -27.054 31.051 1.00 100.31 ? 387 ILE A O   1 
ATOM   2828 C CB  . ILE A 1 361 ? -33.927 -27.399 29.726 1.00 93.56  ? 387 ILE A CB  1 
ATOM   2829 C CG1 . ILE A 1 361 ? -32.960 -28.196 28.844 1.00 90.90  ? 387 ILE A CG1 1 
ATOM   2830 C CG2 . ILE A 1 361 ? -33.109 -26.615 30.740 1.00 96.90  ? 387 ILE A CG2 1 
ATOM   2831 C CD1 . ILE A 1 361 ? -32.448 -27.448 27.649 1.00 75.31  ? 387 ILE A CD1 1 
ATOM   2832 N N   . GLU A 1 362 ? -35.431 -27.697 32.718 1.00 108.69 ? 388 GLU A N   1 
ATOM   2833 C CA  . GLU A 1 362 ? -36.267 -27.235 33.819 1.00 109.91 ? 388 GLU A CA  1 
ATOM   2834 C C   . GLU A 1 362 ? -36.036 -25.747 34.105 1.00 111.71 ? 388 GLU A C   1 
ATOM   2835 O O   . GLU A 1 362 ? -35.247 -25.073 33.438 1.00 114.54 ? 388 GLU A O   1 
ATOM   2836 C CB  . GLU A 1 362 ? -36.010 -28.086 35.065 1.00 107.13 ? 388 GLU A CB  1 
ATOM   2837 N N   . ASP A 1 363 ? -36.733 -25.224 35.117 1.00 113.28 ? 389 ASP A N   1 
ATOM   2838 C CA  . ASP A 1 363 ? -36.611 -23.813 35.492 1.00 110.81 ? 389 ASP A CA  1 
ATOM   2839 C C   . ASP A 1 363 ? -35.953 -23.661 36.860 1.00 106.62 ? 389 ASP A C   1 
ATOM   2840 O O   . ASP A 1 363 ? -34.732 -23.527 36.959 1.00 108.14 ? 389 ASP A O   1 
ATOM   2841 C CB  . ASP A 1 363 ? -37.982 -23.127 35.490 1.00 108.01 ? 389 ASP A CB  1 
ATOM   2842 N N   . VAL A 1 368 ? -33.873 -15.474 38.319 1.00 101.82 ? 394 VAL A N   1 
ATOM   2843 C CA  . VAL A 1 368 ? -33.399 -14.316 37.569 1.00 103.76 ? 394 VAL A CA  1 
ATOM   2844 C C   . VAL A 1 368 ? -33.102 -13.174 38.520 1.00 103.07 ? 394 VAL A C   1 
ATOM   2845 O O   . VAL A 1 368 ? -33.836 -12.944 39.481 1.00 101.70 ? 394 VAL A O   1 
ATOM   2846 C CB  . VAL A 1 368 ? -34.417 -13.871 36.482 1.00 104.67 ? 394 VAL A CB  1 
ATOM   2847 C CG1 . VAL A 1 368 ? -35.672 -13.276 37.109 1.00 103.39 ? 394 VAL A CG1 1 
ATOM   2848 C CG2 . VAL A 1 368 ? -33.782 -12.871 35.525 1.00 99.60  ? 394 VAL A CG2 1 
ATOM   2849 N N   . GLU A 1 369 ? -32.007 -12.467 38.266 1.00 103.72 ? 395 GLU A N   1 
ATOM   2850 C CA  . GLU A 1 369 ? -31.712 -11.248 38.996 1.00 101.30 ? 395 GLU A CA  1 
ATOM   2851 C C   . GLU A 1 369 ? -31.691 -10.067 38.035 1.00 101.67 ? 395 GLU A C   1 
ATOM   2852 O O   . GLU A 1 369 ? -31.525 -10.219 36.820 1.00 96.82  ? 395 GLU A O   1 
ATOM   2853 C CB  . GLU A 1 369 ? -30.386 -11.341 39.753 1.00 98.90  ? 395 GLU A CB  1 
ATOM   2854 C CG  . GLU A 1 369 ? -30.397 -10.525 41.029 1.00 101.30 ? 395 GLU A CG  1 
ATOM   2855 C CD  . GLU A 1 369 ? -29.011 -10.283 41.587 1.00 104.72 ? 395 GLU A CD  1 
ATOM   2856 O OE1 . GLU A 1 369 ? -28.667 -9.102  41.821 1.00 105.58 ? 395 GLU A OE1 1 
ATOM   2857 O OE2 . GLU A 1 369 ? -28.271 -11.269 41.801 1.00 102.62 ? 395 GLU A OE2 1 
ATOM   2858 N N   . THR A 1 370 ? -31.861 -8.881  38.610 1.00 103.19 ? 396 THR A N   1 
ATOM   2859 C CA  . THR A 1 370 ? -32.070 -7.653  37.862 1.00 98.57  ? 396 THR A CA  1 
ATOM   2860 C C   . THR A 1 370 ? -31.185 -6.544  38.406 1.00 97.92  ? 396 THR A C   1 
ATOM   2861 O O   . THR A 1 370 ? -30.655 -6.626  39.519 1.00 99.36  ? 396 THR A O   1 
ATOM   2862 C CB  . THR A 1 370 ? -33.532 -7.227  37.905 1.00 100.42 ? 396 THR A CB  1 
ATOM   2863 O OG1 . THR A 1 370 ? -34.077 -7.543  39.193 1.00 102.28 ? 396 THR A OG1 1 
ATOM   2864 C CG2 . THR A 1 370 ? -34.300 -7.969  36.848 1.00 101.90 ? 396 THR A CG2 1 
ATOM   2865 N N   . PHE A 1 371 ? -31.054 -5.492  37.603 1.00 96.21  ? 397 PHE A N   1 
ATOM   2866 C CA  . PHE A 1 371 ? -30.156 -4.399  37.936 1.00 97.83  ? 397 PHE A CA  1 
ATOM   2867 C C   . PHE A 1 371 ? -30.627 -3.675  39.199 1.00 99.04  ? 397 PHE A C   1 
ATOM   2868 O O   . PHE A 1 371 ? -31.831 -3.569  39.458 1.00 98.30  ? 397 PHE A O   1 
ATOM   2869 C CB  . PHE A 1 371 ? -30.083 -3.406  36.776 1.00 93.58  ? 397 PHE A CB  1 
ATOM   2870 C CG  . PHE A 1 371 ? -29.066 -3.761  35.732 1.00 89.20  ? 397 PHE A CG  1 
ATOM   2871 C CD1 . PHE A 1 371 ? -27.741 -3.973  36.079 1.00 89.89  ? 397 PHE A CD1 1 
ATOM   2872 C CD2 . PHE A 1 371 ? -29.432 -3.871  34.398 1.00 88.14  ? 397 PHE A CD2 1 
ATOM   2873 C CE1 . PHE A 1 371 ? -26.801 -4.290  35.111 1.00 86.12  ? 397 PHE A CE1 1 
ATOM   2874 C CE2 . PHE A 1 371 ? -28.496 -4.192  33.426 1.00 82.61  ? 397 PHE A CE2 1 
ATOM   2875 C CZ  . PHE A 1 371 ? -27.183 -4.398  33.782 1.00 81.30  ? 397 PHE A CZ  1 
ATOM   2876 N N   . PRO A 1 372 ? -29.692 -3.161  40.000 1.00 100.11 ? 398 PRO A N   1 
ATOM   2877 C CA  . PRO A 1 372 ? -30.071 -2.306  41.134 1.00 95.27  ? 398 PRO A CA  1 
ATOM   2878 C C   . PRO A 1 372 ? -30.500 -0.928  40.645 1.00 101.46 ? 398 PRO A C   1 
ATOM   2879 O O   . PRO A 1 372 ? -29.858 -0.345  39.763 1.00 101.76 ? 398 PRO A O   1 
ATOM   2880 C CB  . PRO A 1 372 ? -28.788 -2.234  41.970 1.00 94.16  ? 398 PRO A CB  1 
ATOM   2881 C CG  . PRO A 1 372 ? -27.679 -2.483  40.998 1.00 92.10  ? 398 PRO A CG  1 
ATOM   2882 C CD  . PRO A 1 372 ? -28.232 -3.375  39.917 1.00 94.37  ? 398 PRO A CD  1 
ATOM   2883 N N   . ILE A 1 373 ? -31.628 -0.444  41.172 1.00 101.38 ? 399 ILE A N   1 
ATOM   2884 C CA  . ILE A 1 373 ? -32.105 0.921   40.925 1.00 97.39  ? 399 ILE A CA  1 
ATOM   2885 C C   . ILE A 1 373 ? -30.954 1.886   41.196 1.00 97.54  ? 399 ILE A C   1 
ATOM   2886 O O   . ILE A 1 373 ? -30.368 1.854   42.288 1.00 99.99  ? 399 ILE A O   1 
ATOM   2887 C CB  . ILE A 1 373 ? -33.332 1.263   41.789 1.00 95.17  ? 399 ILE A CB  1 
ATOM   2888 C CG1 . ILE A 1 373 ? -34.514 0.344   41.461 1.00 93.74  ? 399 ILE A CG1 1 
ATOM   2889 C CG2 . ILE A 1 373 ? -33.729 2.731   41.606 1.00 95.89  ? 399 ILE A CG2 1 
ATOM   2890 C CD1 . ILE A 1 373 ? -35.506 0.919   40.457 1.00 95.88  ? 399 ILE A CD1 1 
ATOM   2891 N N   . PRO A 1 374 ? -30.563 2.723   40.236 1.00 98.34  ? 400 PRO A N   1 
ATOM   2892 C CA  . PRO A 1 374 ? -29.346 3.523   40.391 1.00 94.95  ? 400 PRO A CA  1 
ATOM   2893 C C   . PRO A 1 374 ? -29.578 4.836   41.133 1.00 91.88  ? 400 PRO A C   1 
ATOM   2894 O O   . PRO A 1 374 ? -30.682 5.386   41.178 1.00 90.16  ? 400 PRO A O   1 
ATOM   2895 C CB  . PRO A 1 374 ? -28.928 3.785   38.935 1.00 88.93  ? 400 PRO A CB  1 
ATOM   2896 C CG  . PRO A 1 374 ? -30.226 3.854   38.208 1.00 89.15  ? 400 PRO A CG  1 
ATOM   2897 C CD  . PRO A 1 374 ? -31.194 2.930   38.917 1.00 91.19  ? 400 PRO A CD  1 
ATOM   2898 N N   . LYS A 1 375 ? -28.495 5.332   41.726 1.00 89.97  ? 401 LYS A N   1 
ATOM   2899 C CA  . LYS A 1 375 ? -28.521 6.632   42.378 1.00 95.66  ? 401 LYS A CA  1 
ATOM   2900 C C   . LYS A 1 375 ? -27.946 7.741   41.506 1.00 94.61  ? 401 LYS A C   1 
ATOM   2901 O O   . LYS A 1 375 ? -28.371 8.895   41.630 1.00 97.31  ? 401 LYS A O   1 
ATOM   2902 C CB  . LYS A 1 375 ? -27.757 6.577   43.708 1.00 92.12  ? 401 LYS A CB  1 
ATOM   2903 N N   . ALA A 1 376 ? -27.007 7.420   40.625 1.00 92.99  ? 402 ALA A N   1 
ATOM   2904 C CA  . ALA A 1 376 ? -26.528 8.317   39.579 1.00 86.73  ? 402 ALA A CA  1 
ATOM   2905 C C   . ALA A 1 376 ? -26.717 7.633   38.234 1.00 84.68  ? 402 ALA A C   1 
ATOM   2906 O O   . ALA A 1 376 ? -27.168 6.489   38.159 1.00 83.86  ? 402 ALA A O   1 
ATOM   2907 C CB  . ALA A 1 376 ? -25.064 8.698   39.797 1.00 81.93  ? 402 ALA A CB  1 
ATOM   2908 N N   . PHE A 1 377 ? -26.358 8.337   37.164 1.00 84.57  ? 403 PHE A N   1 
ATOM   2909 C CA  . PHE A 1 377 ? -26.381 7.730   35.842 1.00 76.98  ? 403 PHE A CA  1 
ATOM   2910 C C   . PHE A 1 377 ? -25.274 6.689   35.745 1.00 79.54  ? 403 PHE A C   1 
ATOM   2911 O O   . PHE A 1 377 ? -24.087 7.015   35.881 1.00 80.26  ? 403 PHE A O   1 
ATOM   2912 C CB  . PHE A 1 377 ? -26.214 8.791   34.757 1.00 81.36  ? 403 PHE A CB  1 
ATOM   2913 C CG  . PHE A 1 377 ? -26.190 8.230   33.349 1.00 79.34  ? 403 PHE A CG  1 
ATOM   2914 C CD1 . PHE A 1 377 ? -27.372 7.884   32.698 1.00 77.58  ? 403 PHE A CD1 1 
ATOM   2915 C CD2 . PHE A 1 377 ? -24.984 8.051   32.681 1.00 79.22  ? 403 PHE A CD2 1 
ATOM   2916 C CE1 . PHE A 1 377 ? -27.345 7.365   31.406 1.00 76.63  ? 403 PHE A CE1 1 
ATOM   2917 C CE2 . PHE A 1 377 ? -24.947 7.537   31.388 1.00 79.17  ? 403 PHE A CE2 1 
ATOM   2918 C CZ  . PHE A 1 377 ? -26.130 7.195   30.749 1.00 74.73  ? 403 PHE A CZ  1 
ATOM   2919 N N   . VAL A 1 378 ? -25.664 5.435   35.545 1.00 73.08  ? 404 VAL A N   1 
ATOM   2920 C CA  . VAL A 1 378 ? -24.711 4.346   35.374 1.00 78.06  ? 404 VAL A CA  1 
ATOM   2921 C C   . VAL A 1 378 ? -24.570 3.953   33.904 1.00 78.45  ? 404 VAL A C   1 
ATOM   2922 O O   . VAL A 1 378 ? -23.463 3.702   33.428 1.00 75.91  ? 404 VAL A O   1 
ATOM   2923 C CB  . VAL A 1 378 ? -25.083 3.144   36.279 1.00 77.02  ? 404 VAL A CB  1 
ATOM   2924 C CG1 . VAL A 1 378 ? -26.554 2.757   36.156 1.00 75.02  ? 404 VAL A CG1 1 
ATOM   2925 C CG2 . VAL A 1 378 ? -24.159 1.947   36.023 1.00 80.83  ? 404 VAL A CG2 1 
ATOM   2926 N N   . GLY A 1 379 ? -25.677 3.910   33.166 1.00 77.39  ? 405 GLY A N   1 
ATOM   2927 C CA  . GLY A 1 379 ? -25.610 3.610   31.748 1.00 73.48  ? 405 GLY A CA  1 
ATOM   2928 C C   . GLY A 1 379 ? -25.500 2.140   31.418 1.00 72.79  ? 405 GLY A C   1 
ATOM   2929 O O   . GLY A 1 379 ? -24.719 1.755   30.532 1.00 65.46  ? 405 GLY A O   1 
ATOM   2930 N N   . ASN A 1 380 ? -26.272 1.302   32.106 1.00 72.95  ? 406 ASN A N   1 
ATOM   2931 C CA  . ASN A 1 380 ? -26.199 -0.136  31.886 1.00 74.38  ? 406 ASN A CA  1 
ATOM   2932 C C   . ASN A 1 380 ? -26.695 -0.539  30.501 1.00 73.85  ? 406 ASN A C   1 
ATOM   2933 O O   . ASN A 1 380 ? -26.354 -1.632  30.035 1.00 76.93  ? 406 ASN A O   1 
ATOM   2934 C CB  . ASN A 1 380 ? -26.998 -0.870  32.965 1.00 76.92  ? 406 ASN A CB  1 
ATOM   2935 C CG  . ASN A 1 380 ? -26.284 -0.889  34.296 1.00 76.59  ? 406 ASN A CG  1 
ATOM   2936 O OD1 . ASN A 1 380 ? -25.051 -0.968  34.352 1.00 69.90  ? 406 ASN A OD1 1 
ATOM   2937 N ND2 . ASN A 1 380 ? -27.053 -0.809  35.381 1.00 77.55  ? 406 ASN A ND2 1 
ATOM   2938 N N   . GLN A 1 381 ? -27.505 0.292   29.843 1.00 64.54  ? 407 GLN A N   1 
ATOM   2939 C CA  . GLN A 1 381 ? -28.026 -0.046  28.527 1.00 67.79  ? 407 GLN A CA  1 
ATOM   2940 C C   . GLN A 1 381 ? -27.132 0.401   27.376 1.00 68.45  ? 407 GLN A C   1 
ATOM   2941 O O   . GLN A 1 381 ? -27.346 -0.039  26.245 1.00 63.89  ? 407 GLN A O   1 
ATOM   2942 C CB  . GLN A 1 381 ? -29.424 0.553   28.359 1.00 67.44  ? 407 GLN A CB  1 
ATOM   2943 C CG  . GLN A 1 381 ? -30.411 0.096   29.418 1.00 64.99  ? 407 GLN A CG  1 
ATOM   2944 C CD  . GLN A 1 381 ? -30.965 -1.283  29.128 1.00 70.27  ? 407 GLN A CD  1 
ATOM   2945 O OE1 . GLN A 1 381 ? -30.631 -1.899  28.111 1.00 70.07  ? 407 GLN A OE1 1 
ATOM   2946 N NE2 . GLN A 1 381 ? -31.831 -1.771  30.006 1.00 67.88  ? 407 GLN A NE2 1 
ATOM   2947 N N   . LEU A 1 382 ? -26.118 1.227   27.633 1.00 67.75  ? 408 LEU A N   1 
ATOM   2948 C CA  . LEU A 1 382 ? -25.268 1.718   26.550 1.00 65.26  ? 408 LEU A CA  1 
ATOM   2949 C C   . LEU A 1 382 ? -24.535 0.626   25.769 1.00 64.65  ? 408 LEU A C   1 
ATOM   2950 O O   . LEU A 1 382 ? -24.353 0.806   24.549 1.00 62.24  ? 408 LEU A O   1 
ATOM   2951 C CB  . LEU A 1 382 ? -24.252 2.731   27.095 1.00 66.38  ? 408 LEU A CB  1 
ATOM   2952 C CG  . LEU A 1 382 ? -24.745 4.059   27.673 1.00 69.09  ? 408 LEU A CG  1 
ATOM   2953 C CD1 . LEU A 1 382 ? -23.544 4.840   28.209 1.00 70.06  ? 408 LEU A CD1 1 
ATOM   2954 C CD2 . LEU A 1 382 ? -25.510 4.890   26.640 1.00 64.42  ? 408 LEU A CD2 1 
ATOM   2955 N N   . PRO A 1 383 ? -24.058 -0.476  26.366 1.00 63.66  ? 409 PRO A N   1 
ATOM   2956 C CA  . PRO A 1 383 ? -23.333 -1.472  25.553 1.00 66.62  ? 409 PRO A CA  1 
ATOM   2957 C C   . PRO A 1 383 ? -24.213 -2.213  24.547 1.00 65.14  ? 409 PRO A C   1 
ATOM   2958 O O   . PRO A 1 383 ? -23.683 -2.880  23.653 1.00 64.73  ? 409 PRO A O   1 
ATOM   2959 C CB  . PRO A 1 383 ? -22.758 -2.439  26.607 1.00 66.68  ? 409 PRO A CB  1 
ATOM   2960 C CG  . PRO A 1 383 ? -22.764 -1.678  27.881 1.00 69.88  ? 409 PRO A CG  1 
ATOM   2961 C CD  . PRO A 1 383 ? -23.998 -0.825  27.801 1.00 71.77  ? 409 PRO A CD  1 
ATOM   2962 N N   . PHE A 1 384 ? -25.532 -2.108  24.643 1.00 66.93  ? 410 PHE A N   1 
ATOM   2963 C CA  . PHE A 1 384 ? -26.420 -2.858  23.768 1.00 62.33  ? 410 PHE A CA  1 
ATOM   2964 C C   . PHE A 1 384 ? -27.023 -1.989  22.671 1.00 62.27  ? 410 PHE A C   1 
ATOM   2965 O O   . PHE A 1 384 ? -27.927 -2.439  21.955 1.00 60.55  ? 410 PHE A O   1 
ATOM   2966 C CB  . PHE A 1 384 ? -27.475 -3.539  24.626 1.00 62.21  ? 410 PHE A CB  1 
ATOM   2967 C CG  . PHE A 1 384 ? -26.878 -4.216  25.835 1.00 66.83  ? 410 PHE A CG  1 
ATOM   2968 C CD1 . PHE A 1 384 ? -26.078 -5.340  25.682 1.00 66.79  ? 410 PHE A CD1 1 
ATOM   2969 C CD2 . PHE A 1 384 ? -27.058 -3.696  27.113 1.00 67.48  ? 410 PHE A CD2 1 
ATOM   2970 C CE1 . PHE A 1 384 ? -25.496 -5.957  26.786 1.00 67.95  ? 410 PHE A CE1 1 
ATOM   2971 C CE2 . PHE A 1 384 ? -26.478 -4.314  28.222 1.00 66.34  ? 410 PHE A CE2 1 
ATOM   2972 C CZ  . PHE A 1 384 ? -25.704 -5.443  28.058 1.00 66.51  ? 410 PHE A CZ  1 
ATOM   2973 N N   . ILE A 1 385 ? -26.515 -0.764  22.506 1.00 62.65  ? 411 ILE A N   1 
ATOM   2974 C CA  . ILE A 1 385 ? -27.016 0.139   21.480 1.00 58.80  ? 411 ILE A CA  1 
ATOM   2975 C C   . ILE A 1 385 ? -26.514 -0.321  20.118 1.00 67.77  ? 411 ILE A C   1 
ATOM   2976 O O   . ILE A 1 385 ? -25.306 -0.514  19.918 1.00 64.78  ? 411 ILE A O   1 
ATOM   2977 C CB  . ILE A 1 385 ? -26.583 1.585   21.779 1.00 62.61  ? 411 ILE A CB  1 
ATOM   2978 C CG1 . ILE A 1 385 ? -27.349 2.124   22.993 1.00 62.66  ? 411 ILE A CG1 1 
ATOM   2979 C CG2 . ILE A 1 385 ? -26.832 2.500   20.561 1.00 62.22  ? 411 ILE A CG2 1 
ATOM   2980 C CD1 . ILE A 1 385 ? -26.799 3.412   23.530 1.00 64.13  ? 411 ILE A CD1 1 
ATOM   2981 N N   . GLY A 1 386 ? -27.446 -0.504  19.174 1.00 56.73  ? 412 GLY A N   1 
ATOM   2982 C CA  . GLY A 1 386 ? -27.133 -1.020  17.859 1.00 55.55  ? 412 GLY A CA  1 
ATOM   2983 C C   . GLY A 1 386 ? -27.360 -2.503  17.691 1.00 56.49  ? 412 GLY A C   1 
ATOM   2984 O O   . GLY A 1 386 ? -27.095 -3.034  16.608 1.00 61.49  ? 412 GLY A O   1 
ATOM   2985 N N   . PHE A 1 387 ? -27.829 -3.190  18.727 1.00 56.12  ? 413 PHE A N   1 
ATOM   2986 C CA  . PHE A 1 387 ? -28.071 -4.619  18.610 1.00 55.35  ? 413 PHE A CA  1 
ATOM   2987 C C   . PHE A 1 387 ? -29.296 -4.898  17.746 1.00 58.76  ? 413 PHE A C   1 
ATOM   2988 O O   . PHE A 1 387 ? -29.347 -5.921  17.054 1.00 60.88  ? 413 PHE A O   1 
ATOM   2989 C CB  . PHE A 1 387 ? -28.223 -5.249  20.007 1.00 56.02  ? 413 PHE A CB  1 
ATOM   2990 C CG  . PHE A 1 387 ? -28.290 -6.758  19.984 1.00 58.23  ? 413 PHE A CG  1 
ATOM   2991 C CD1 . PHE A 1 387 ? -27.140 -7.516  19.744 1.00 58.86  ? 413 PHE A CD1 1 
ATOM   2992 C CD2 . PHE A 1 387 ? -29.500 -7.416  20.169 1.00 55.95  ? 413 PHE A CD2 1 
ATOM   2993 C CE1 . PHE A 1 387 ? -27.204 -8.906  19.689 1.00 60.75  ? 413 PHE A CE1 1 
ATOM   2994 C CE2 . PHE A 1 387 ? -29.573 -8.804  20.114 1.00 59.20  ? 413 PHE A CE2 1 
ATOM   2995 C CZ  . PHE A 1 387 ? -28.420 -9.549  19.883 1.00 61.53  ? 413 PHE A CZ  1 
ATOM   2996 N N   . THR A 1 388 ? -30.295 -4.020  17.790 1.00 57.93  ? 414 THR A N   1 
ATOM   2997 C CA  . THR A 1 388 ? -31.548 -4.270  17.079 1.00 61.90  ? 414 THR A CA  1 
ATOM   2998 C C   . THR A 1 388 ? -31.324 -4.439  15.580 1.00 56.36  ? 414 THR A C   1 
ATOM   2999 O O   . THR A 1 388 ? -30.606 -3.666  14.942 1.00 57.93  ? 414 THR A O   1 
ATOM   3000 C CB  . THR A 1 388 ? -32.538 -3.129  17.337 1.00 58.80  ? 414 THR A CB  1 
ATOM   3001 O OG1 . THR A 1 388 ? -32.801 -3.061  18.742 1.00 55.67  ? 414 THR A OG1 1 
ATOM   3002 C CG2 . THR A 1 388 ? -33.872 -3.380  16.594 1.00 61.67  ? 414 THR A CG2 1 
ATOM   3003 N N   . TYR A 1 389 ? -31.973 -5.434  14.997 1.00 56.84  ? 415 TYR A N   1 
ATOM   3004 C CA  . TYR A 1 389 ? -31.776 -5.629  13.566 1.00 65.64  ? 415 TYR A CA  1 
ATOM   3005 C C   . TYR A 1 389 ? -33.011 -6.252  12.934 1.00 65.82  ? 415 TYR A C   1 
ATOM   3006 O O   . TYR A 1 389 ? -33.540 -7.242  13.454 1.00 63.40  ? 415 TYR A O   1 
ATOM   3007 C CB  . TYR A 1 389 ? -30.549 -6.498  13.316 1.00 61.08  ? 415 TYR A CB  1 
ATOM   3008 C CG  . TYR A 1 389 ? -30.465 -7.065  11.936 1.00 63.83  ? 415 TYR A CG  1 
ATOM   3009 C CD1 . TYR A 1 389 ? -29.850 -6.360  10.910 1.00 65.40  ? 415 TYR A CD1 1 
ATOM   3010 C CD2 . TYR A 1 389 ? -30.986 -8.320  11.655 1.00 65.40  ? 415 TYR A CD2 1 
ATOM   3011 C CE1 . TYR A 1 389 ? -29.755 -6.894  9.641  1.00 63.68  ? 415 TYR A CE1 1 
ATOM   3012 C CE2 . TYR A 1 389 ? -30.911 -8.849  10.391 1.00 67.08  ? 415 TYR A CE2 1 
ATOM   3013 C CZ  . TYR A 1 389 ? -30.290 -8.140  9.392  1.00 62.65  ? 415 TYR A CZ  1 
ATOM   3014 O OH  . TYR A 1 389 ? -30.223 -8.686  8.136  1.00 71.27  ? 415 TYR A OH  1 
ATOM   3015 N N   . TYR A 1 390 ? -33.466 -5.644  11.833 1.00 66.07  ? 416 TYR A N   1 
ATOM   3016 C CA  . TYR A 1 390 ? -34.587 -6.128  11.008 1.00 75.34  ? 416 TYR A CA  1 
ATOM   3017 C C   . TYR A 1 390 ? -34.168 -6.248  9.531  1.00 71.38  ? 416 TYR A C   1 
ATOM   3018 O O   . TYR A 1 390 ? -34.112 -7.346  8.958  1.00 74.34  ? 416 TYR A O   1 
ATOM   3019 C CB  . TYR A 1 390 ? -35.808 -5.195  11.103 1.00 73.95  ? 416 TYR A CB  1 
ATOM   3020 C CG  . TYR A 1 390 ? -36.334 -4.916  12.492 1.00 83.21  ? 416 TYR A CG  1 
ATOM   3021 C CD1 . TYR A 1 390 ? -36.415 -5.916  13.456 1.00 81.82  ? 416 TYR A CD1 1 
ATOM   3022 C CD2 . TYR A 1 390 ? -36.797 -3.650  12.833 1.00 90.35  ? 416 TYR A CD2 1 
ATOM   3023 C CE1 . TYR A 1 390 ? -36.912 -5.638  14.758 1.00 83.91  ? 416 TYR A CE1 1 
ATOM   3024 C CE2 . TYR A 1 390 ? -37.301 -3.361  14.117 1.00 89.57  ? 416 TYR A CE2 1 
ATOM   3025 C CZ  . TYR A 1 390 ? -37.358 -4.352  15.073 1.00 87.54  ? 416 TYR A CZ  1 
ATOM   3026 O OH  . TYR A 1 390 ? -37.856 -4.054  16.333 1.00 89.82  ? 416 TYR A OH  1 
ATOM   3027 N N   . LYS B 1 3   ? -5.891  -65.946 63.130 1.00 94.32  ? 29  LYS B N   1 
ATOM   3028 C CA  . LYS B 1 3   ? -7.274  -66.381 63.289 1.00 92.59  ? 29  LYS B CA  1 
ATOM   3029 C C   . LYS B 1 3   ? -8.205  -65.434 62.555 1.00 92.84  ? 29  LYS B C   1 
ATOM   3030 O O   . LYS B 1 3   ? -7.898  -64.258 62.357 1.00 91.02  ? 29  LYS B O   1 
ATOM   3031 C CB  . LYS B 1 3   ? -7.678  -66.461 64.767 1.00 84.54  ? 29  LYS B CB  1 
ATOM   3032 N N   . LEU B 1 4   ? -9.365  -65.960 62.173 1.00 92.89  ? 30  LEU B N   1 
ATOM   3033 C CA  . LEU B 1 4   ? -10.354 -65.147 61.484 1.00 85.53  ? 30  LEU B CA  1 
ATOM   3034 C C   . LEU B 1 4   ? -11.182 -64.347 62.480 1.00 83.96  ? 30  LEU B C   1 
ATOM   3035 O O   . LEU B 1 4   ? -11.575 -63.214 62.184 1.00 82.91  ? 30  LEU B O   1 
ATOM   3036 C CB  . LEU B 1 4   ? -11.229 -66.043 60.604 1.00 86.42  ? 30  LEU B CB  1 
ATOM   3037 C CG  . LEU B 1 4   ? -12.653 -65.621 60.251 1.00 86.16  ? 30  LEU B CG  1 
ATOM   3038 C CD1 . LEU B 1 4   ? -12.636 -64.449 59.278 1.00 81.44  ? 30  LEU B CD1 1 
ATOM   3039 C CD2 . LEU B 1 4   ? -13.429 -66.801 59.663 1.00 88.26  ? 30  LEU B CD2 1 
ATOM   3040 N N   . GLU B 1 5   ? -11.437 -64.901 63.668 1.00 88.50  ? 31  GLU B N   1 
ATOM   3041 C CA  . GLU B 1 5   ? -12.156 -64.148 64.688 1.00 87.07  ? 31  GLU B CA  1 
ATOM   3042 C C   . GLU B 1 5   ? -11.370 -62.934 65.171 1.00 89.51  ? 31  GLU B C   1 
ATOM   3043 O O   . GLU B 1 5   ? -11.961 -62.041 65.791 1.00 89.28  ? 31  GLU B O   1 
ATOM   3044 C CB  . GLU B 1 5   ? -12.496 -65.056 65.876 1.00 83.79  ? 31  GLU B CB  1 
ATOM   3045 N N   . ALA B 1 6   ? -10.070 -62.855 64.866 1.00 89.45  ? 32  ALA B N   1 
ATOM   3046 C CA  . ALA B 1 6   ? -9.311  -61.650 65.188 1.00 86.88  ? 32  ALA B CA  1 
ATOM   3047 C C   . ALA B 1 6   ? -9.746  -60.469 64.326 1.00 86.43  ? 32  ALA B C   1 
ATOM   3048 O O   . ALA B 1 6   ? -10.100 -59.408 64.851 1.00 86.64  ? 32  ALA B O   1 
ATOM   3049 C CB  . ALA B 1 6   ? -7.813  -61.915 65.024 1.00 85.76  ? 32  ALA B CB  1 
ATOM   3050 N N   . LEU B 1 7   ? -9.761  -60.640 62.999 1.00 85.75  ? 33  LEU B N   1 
ATOM   3051 C CA  . LEU B 1 7   ? -10.107 -59.507 62.140 1.00 87.62  ? 33  LEU B CA  1 
ATOM   3052 C C   . LEU B 1 7   ? -11.595 -59.168 62.157 1.00 85.00  ? 33  LEU B C   1 
ATOM   3053 O O   . LEU B 1 7   ? -11.958 -58.060 61.757 1.00 86.53  ? 33  LEU B O   1 
ATOM   3054 C CB  . LEU B 1 7   ? -9.629  -59.718 60.705 1.00 82.29  ? 33  LEU B CB  1 
ATOM   3055 C CG  . LEU B 1 7   ? -9.937  -60.966 59.899 1.00 85.86  ? 33  LEU B CG  1 
ATOM   3056 C CD1 . LEU B 1 7   ? -9.911  -60.610 58.430 1.00 86.92  ? 33  LEU B CD1 1 
ATOM   3057 C CD2 . LEU B 1 7   ? -8.921  -62.039 60.192 1.00 87.05  ? 33  LEU B CD2 1 
ATOM   3058 N N   . ILE B 1 8   ? -12.470 -60.087 62.576 1.00 85.24  ? 34  ILE B N   1 
ATOM   3059 C CA  . ILE B 1 8   ? -13.878 -59.716 62.734 1.00 80.73  ? 34  ILE B CA  1 
ATOM   3060 C C   . ILE B 1 8   ? -14.049 -58.772 63.922 1.00 84.36  ? 34  ILE B C   1 
ATOM   3061 O O   . ILE B 1 8   ? -14.914 -57.885 63.899 1.00 85.35  ? 34  ILE B O   1 
ATOM   3062 C CB  . ILE B 1 8   ? -14.775 -60.968 62.880 1.00 81.18  ? 34  ILE B CB  1 
ATOM   3063 C CG1 . ILE B 1 8   ? -14.521 -61.965 61.747 1.00 81.03  ? 34  ILE B CG1 1 
ATOM   3064 C CG2 . ILE B 1 8   ? -16.252 -60.595 62.934 1.00 77.59  ? 34  ILE B CG2 1 
ATOM   3065 C CD1 . ILE B 1 8   ? -14.882 -61.466 60.405 1.00 75.98  ? 34  ILE B CD1 1 
ATOM   3066 N N   . ARG B 1 9   ? -13.224 -58.926 64.972 1.00 87.67  ? 35  ARG B N   1 
ATOM   3067 C CA  . ARG B 1 9   ? -13.377 -58.118 66.180 1.00 85.50  ? 35  ARG B CA  1 
ATOM   3068 C C   . ARG B 1 9   ? -12.714 -56.744 66.064 1.00 85.43  ? 35  ARG B C   1 
ATOM   3069 O O   . ARG B 1 9   ? -13.110 -55.819 66.784 1.00 82.82  ? 35  ARG B O   1 
ATOM   3070 C CB  . ARG B 1 9   ? -12.816 -58.882 67.388 1.00 82.32  ? 35  ARG B CB  1 
ATOM   3071 N N   . ASP B 1 10  ? -11.766 -56.576 65.141 1.00 86.25  ? 36  ASP B N   1 
ATOM   3072 C CA  . ASP B 1 10  ? -11.012 -55.329 65.006 1.00 83.35  ? 36  ASP B CA  1 
ATOM   3073 C C   . ASP B 1 10  ? -11.869 -54.245 64.355 1.00 84.97  ? 36  ASP B C   1 
ATOM   3074 O O   . ASP B 1 10  ? -12.296 -54.417 63.209 1.00 83.74  ? 36  ASP B O   1 
ATOM   3075 C CB  . ASP B 1 10  ? -9.760  -55.584 64.171 1.00 85.76  ? 36  ASP B CB  1 
ATOM   3076 C CG  . ASP B 1 10  ? -8.921  -54.326 63.942 1.00 89.05  ? 36  ASP B CG  1 
ATOM   3077 O OD1 . ASP B 1 10  ? -9.184  -53.277 64.569 1.00 90.14  ? 36  ASP B OD1 1 
ATOM   3078 O OD2 . ASP B 1 10  ? -7.980  -54.394 63.121 1.00 87.88  ? 36  ASP B OD2 1 
ATOM   3079 N N   . PRO B 1 11  ? -12.107 -53.106 65.022 1.00 84.42  ? 37  PRO B N   1 
ATOM   3080 C CA  . PRO B 1 11  ? -12.964 -52.068 64.422 1.00 80.97  ? 37  PRO B CA  1 
ATOM   3081 C C   . PRO B 1 11  ? -12.364 -51.427 63.186 1.00 83.64  ? 37  PRO B C   1 
ATOM   3082 O O   . PRO B 1 11  ? -13.101 -50.777 62.432 1.00 79.94  ? 37  PRO B O   1 
ATOM   3083 C CB  . PRO B 1 11  ? -13.124 -51.033 65.547 1.00 82.27  ? 37  PRO B CB  1 
ATOM   3084 C CG  . PRO B 1 11  ? -12.632 -51.717 66.796 1.00 89.69  ? 37  PRO B CG  1 
ATOM   3085 C CD  . PRO B 1 11  ? -11.595 -52.692 66.339 1.00 86.91  ? 37  PRO B CD  1 
ATOM   3086 N N   . ARG B 1 12  ? -11.058 -51.578 62.956 1.00 83.40  ? 38  ARG B N   1 
ATOM   3087 C CA  . ARG B 1 12  ? -10.427 -51.065 61.750 1.00 83.45  ? 38  ARG B CA  1 
ATOM   3088 C C   . ARG B 1 12  ? -10.519 -52.033 60.580 1.00 84.87  ? 38  ARG B C   1 
ATOM   3089 O O   . ARG B 1 12  ? -10.159 -51.659 59.458 1.00 88.72  ? 38  ARG B O   1 
ATOM   3090 C CB  . ARG B 1 12  ? -8.949  -50.742 62.024 1.00 87.98  ? 38  ARG B CB  1 
ATOM   3091 C CG  . ARG B 1 12  ? -8.513  -49.351 61.586 1.00 86.46  ? 38  ARG B CG  1 
ATOM   3092 C CD  . ARG B 1 12  ? -6.995  -49.225 61.522 1.00 90.59  ? 38  ARG B CD  1 
ATOM   3093 N NE  . ARG B 1 12  ? -6.552  -47.924 61.007 1.00 92.24  ? 38  ARG B NE  1 
ATOM   3094 C CZ  . ARG B 1 12  ? -6.726  -47.499 59.756 1.00 97.03  ? 38  ARG B CZ  1 
ATOM   3095 N NH1 . ARG B 1 12  ? -7.343  -48.270 58.858 1.00 99.30  ? 38  ARG B NH1 1 
ATOM   3096 N NH2 . ARG B 1 12  ? -6.281  -46.294 59.400 1.00 93.07  ? 38  ARG B NH2 1 
ATOM   3097 N N   . SER B 1 13  ? -10.991 -53.256 60.805 1.00 82.96  ? 39  SER B N   1 
ATOM   3098 C CA  . SER B 1 13  ? -11.084 -54.220 59.725 1.00 81.97  ? 39  SER B CA  1 
ATOM   3099 C C   . SER B 1 13  ? -12.231 -53.858 58.783 1.00 80.81  ? 39  SER B C   1 
ATOM   3100 O O   . SER B 1 13  ? -13.265 -53.341 59.217 1.00 77.46  ? 39  SER B O   1 
ATOM   3101 C CB  . SER B 1 13  ? -11.292 -55.624 60.271 1.00 81.69  ? 39  SER B CB  1 
ATOM   3102 O OG  . SER B 1 13  ? -11.904 -56.464 59.304 1.00 85.57  ? 39  SER B OG  1 
ATOM   3103 N N   . PRO B 1 14  ? -12.075 -54.126 57.482 1.00 78.00  ? 40  PRO B N   1 
ATOM   3104 C CA  . PRO B 1 14  ? -13.206 -53.961 56.555 1.00 77.73  ? 40  PRO B CA  1 
ATOM   3105 C C   . PRO B 1 14  ? -14.360 -54.935 56.781 1.00 79.35  ? 40  PRO B C   1 
ATOM   3106 O O   . PRO B 1 14  ? -15.447 -54.682 56.251 1.00 76.80  ? 40  PRO B O   1 
ATOM   3107 C CB  . PRO B 1 14  ? -12.567 -54.184 55.180 1.00 77.13  ? 40  PRO B CB  1 
ATOM   3108 C CG  . PRO B 1 14  ? -11.336 -55.004 55.462 1.00 79.44  ? 40  PRO B CG  1 
ATOM   3109 C CD  . PRO B 1 14  ? -10.838 -54.534 56.795 1.00 76.31  ? 40  PRO B CD  1 
ATOM   3110 N N   . ILE B 1 15  ? -14.187 -56.018 57.549 1.00 78.68  ? 41  ILE B N   1 
ATOM   3111 C CA  . ILE B 1 15  ? -15.273 -56.983 57.720 1.00 78.47  ? 41  ILE B CA  1 
ATOM   3112 C C   . ILE B 1 15  ? -15.599 -57.223 59.187 1.00 76.29  ? 41  ILE B C   1 
ATOM   3113 O O   . ILE B 1 15  ? -15.985 -58.330 59.570 1.00 80.63  ? 41  ILE B O   1 
ATOM   3114 C CB  . ILE B 1 15  ? -14.972 -58.329 57.032 1.00 73.95  ? 41  ILE B CB  1 
ATOM   3115 C CG1 . ILE B 1 15  ? -13.803 -59.044 57.695 1.00 80.25  ? 41  ILE B CG1 1 
ATOM   3116 C CG2 . ILE B 1 15  ? -14.703 -58.136 55.560 1.00 72.37  ? 41  ILE B CG2 1 
ATOM   3117 C CD1 . ILE B 1 15  ? -13.316 -60.198 56.890 1.00 84.86  ? 41  ILE B CD1 1 
ATOM   3118 N N   . ASN B 1 16  ? -15.525 -56.185 60.007 1.00 78.22  ? 42  ASN B N   1 
ATOM   3119 C CA  . ASN B 1 16  ? -16.054 -56.311 61.353 1.00 79.15  ? 42  ASN B CA  1 
ATOM   3120 C C   . ASN B 1 16  ? -17.576 -56.503 61.302 1.00 75.50  ? 42  ASN B C   1 
ATOM   3121 O O   . ASN B 1 16  ? -18.217 -56.354 60.256 1.00 72.72  ? 42  ASN B O   1 
ATOM   3122 C CB  . ASN B 1 16  ? -15.710 -55.070 62.152 1.00 79.85  ? 42  ASN B CB  1 
ATOM   3123 C CG  . ASN B 1 16  ? -16.241 -53.824 61.498 1.00 81.72  ? 42  ASN B CG  1 
ATOM   3124 O OD1 . ASN B 1 16  ? -17.448 -53.565 61.520 1.00 82.31  ? 42  ASN B OD1 1 
ATOM   3125 N ND2 . ASN B 1 16  ? -15.354 -53.063 60.868 1.00 82.50  ? 42  ASN B ND2 1 
ATOM   3126 N N   . VAL B 1 17  ? -18.165 -56.792 62.461 1.00 70.48  ? 43  VAL B N   1 
ATOM   3127 C CA  . VAL B 1 17  ? -19.591 -57.131 62.497 1.00 72.61  ? 43  VAL B CA  1 
ATOM   3128 C C   . VAL B 1 17  ? -20.439 -56.001 61.925 1.00 76.77  ? 43  VAL B C   1 
ATOM   3129 O O   . VAL B 1 17  ? -21.425 -56.250 61.219 1.00 75.09  ? 43  VAL B O   1 
ATOM   3130 C CB  . VAL B 1 17  ? -20.028 -57.502 63.927 1.00 73.59  ? 43  VAL B CB  1 
ATOM   3131 C CG1 . VAL B 1 17  ? -21.570 -57.528 64.053 1.00 73.00  ? 43  VAL B CG1 1 
ATOM   3132 C CG2 . VAL B 1 17  ? -19.454 -58.855 64.292 1.00 74.55  ? 43  VAL B CG2 1 
ATOM   3133 N N   . GLU B 1 18  ? -20.032 -54.746 62.143 1.00 77.52  ? 44  GLU B N   1 
ATOM   3134 C CA  . GLU B 1 18  ? -20.867 -53.644 61.672 1.00 76.97  ? 44  GLU B CA  1 
ATOM   3135 C C   . GLU B 1 18  ? -20.763 -53.476 60.162 1.00 73.78  ? 44  GLU B C   1 
ATOM   3136 O O   . GLU B 1 18  ? -21.730 -53.052 59.517 1.00 72.53  ? 44  GLU B O   1 
ATOM   3137 C CB  . GLU B 1 18  ? -20.449 -52.329 62.338 1.00 74.05  ? 44  GLU B CB  1 
ATOM   3138 C CG  . GLU B 1 18  ? -20.720 -52.204 63.808 1.00 73.35  ? 44  GLU B CG  1 
ATOM   3139 C CD  . GLU B 1 18  ? -22.184 -51.935 64.133 1.00 85.63  ? 44  GLU B CD  1 
ATOM   3140 O OE1 . GLU B 1 18  ? -22.962 -51.651 63.190 1.00 84.11  ? 44  GLU B OE1 1 
ATOM   3141 O OE2 . GLU B 1 18  ? -22.544 -51.967 65.339 1.00 85.31  ? 44  GLU B OE2 1 
ATOM   3142 N N   . SER B 1 19  ? -19.647 -53.896 59.569 1.00 71.65  ? 45  SER B N   1 
ATOM   3143 C CA  . SER B 1 19  ? -19.560 -53.906 58.116 1.00 70.45  ? 45  SER B CA  1 
ATOM   3144 C C   . SER B 1 19  ? -20.351 -55.059 57.523 1.00 70.49  ? 45  SER B C   1 
ATOM   3145 O O   . SER B 1 19  ? -20.994 -54.903 56.482 1.00 71.77  ? 45  SER B O   1 
ATOM   3146 C CB  . SER B 1 19  ? -18.098 -53.961 57.688 1.00 71.90  ? 45  SER B CB  1 
ATOM   3147 O OG  . SER B 1 19  ? -17.399 -52.871 58.272 1.00 80.27  ? 45  SER B OG  1 
ATOM   3148 N N   . LEU B 1 20  ? -20.309 -56.226 58.158 1.00 68.51  ? 46  LEU B N   1 
ATOM   3149 C CA  . LEU B 1 20  ? -21.119 -57.332 57.680 1.00 68.50  ? 46  LEU B CA  1 
ATOM   3150 C C   . LEU B 1 20  ? -22.594 -56.973 57.768 1.00 66.16  ? 46  LEU B C   1 
ATOM   3151 O O   . LEU B 1 20  ? -23.363 -57.269 56.855 1.00 62.72  ? 46  LEU B O   1 
ATOM   3152 C CB  . LEU B 1 20  ? -20.815 -58.603 58.476 1.00 70.34  ? 46  LEU B CB  1 
ATOM   3153 C CG  . LEU B 1 20  ? -19.348 -59.046 58.402 1.00 65.61  ? 46  LEU B CG  1 
ATOM   3154 C CD1 . LEU B 1 20  ? -19.107 -60.269 59.242 1.00 67.44  ? 46  LEU B CD1 1 
ATOM   3155 C CD2 . LEU B 1 20  ? -18.927 -59.298 56.981 1.00 65.74  ? 46  LEU B CD2 1 
ATOM   3156 N N   . LEU B 1 21  ? -23.001 -56.309 58.850 1.00 68.64  ? 47  LEU B N   1 
ATOM   3157 C CA  . LEU B 1 21  ? -24.383 -55.848 58.957 1.00 72.39  ? 47  LEU B CA  1 
ATOM   3158 C C   . LEU B 1 21  ? -24.719 -54.831 57.868 1.00 76.76  ? 47  LEU B C   1 
ATOM   3159 O O   . LEU B 1 21  ? -25.822 -54.861 57.302 1.00 75.63  ? 47  LEU B O   1 
ATOM   3160 C CB  . LEU B 1 21  ? -24.640 -55.265 60.348 1.00 71.59  ? 47  LEU B CB  1 
ATOM   3161 C CG  . LEU B 1 21  ? -24.700 -56.314 61.458 1.00 75.05  ? 47  LEU B CG  1 
ATOM   3162 C CD1 . LEU B 1 21  ? -24.816 -55.666 62.842 1.00 69.73  ? 47  LEU B CD1 1 
ATOM   3163 C CD2 . LEU B 1 21  ? -25.836 -57.302 61.210 1.00 65.77  ? 47  LEU B CD2 1 
ATOM   3164 N N   . ASP B 1 22  ? -23.792 -53.910 57.574 1.00 70.26  ? 48  ASP B N   1 
ATOM   3165 C CA  . ASP B 1 22  ? -23.979 -53.013 56.433 1.00 72.34  ? 48  ASP B CA  1 
ATOM   3166 C C   . ASP B 1 22  ? -24.229 -53.802 55.159 1.00 74.85  ? 48  ASP B C   1 
ATOM   3167 O O   . ASP B 1 22  ? -25.087 -53.438 54.346 1.00 75.06  ? 48  ASP B O   1 
ATOM   3168 C CB  . ASP B 1 22  ? -22.748 -52.122 56.231 1.00 75.66  ? 48  ASP B CB  1 
ATOM   3169 C CG  . ASP B 1 22  ? -22.778 -50.839 57.057 1.00 73.32  ? 48  ASP B CG  1 
ATOM   3170 O OD1 . ASP B 1 22  ? -23.816 -50.489 57.678 1.00 72.99  ? 48  ASP B OD1 1 
ATOM   3171 O OD2 . ASP B 1 22  ? -21.718 -50.176 57.071 1.00 75.28  ? 48  ASP B OD2 1 
ATOM   3172 N N   . GLY B 1 23  ? -23.458 -54.871 54.956 1.00 72.57  ? 49  GLY B N   1 
ATOM   3173 C CA  . GLY B 1 23  ? -23.583 -55.641 53.735 1.00 69.71  ? 49  GLY B CA  1 
ATOM   3174 C C   . GLY B 1 23  ? -24.920 -56.344 53.629 1.00 70.94  ? 49  GLY B C   1 
ATOM   3175 O O   . GLY B 1 23  ? -25.544 -56.345 52.568 1.00 72.40  ? 49  GLY B O   1 
ATOM   3176 N N   . LEU B 1 24  ? -25.382 -56.945 54.725 1.00 69.97  ? 50  LEU B N   1 
ATOM   3177 C CA  . LEU B 1 24  ? -26.706 -57.555 54.710 1.00 73.87  ? 50  LEU B CA  1 
ATOM   3178 C C   . LEU B 1 24  ? -27.772 -56.509 54.413 1.00 76.96  ? 50  LEU B C   1 
ATOM   3179 O O   . LEU B 1 24  ? -28.611 -56.699 53.527 1.00 74.59  ? 50  LEU B O   1 
ATOM   3180 C CB  . LEU B 1 24  ? -26.988 -58.257 56.040 1.00 69.36  ? 50  LEU B CB  1 
ATOM   3181 C CG  . LEU B 1 24  ? -28.384 -58.882 56.178 1.00 75.04  ? 50  LEU B CG  1 
ATOM   3182 C CD1 . LEU B 1 24  ? -28.697 -59.813 55.013 1.00 74.42  ? 50  LEU B CD1 1 
ATOM   3183 C CD2 . LEU B 1 24  ? -28.555 -59.602 57.502 1.00 70.67  ? 50  LEU B CD2 1 
ATOM   3184 N N   . ASN B 1 25  ? -27.731 -55.383 55.134 1.00 71.99  ? 51  ASN B N   1 
ATOM   3185 C CA  . ASN B 1 25  ? -28.752 -54.354 54.980 1.00 70.24  ? 51  ASN B CA  1 
ATOM   3186 C C   . ASN B 1 25  ? -28.752 -53.753 53.576 1.00 78.10  ? 51  ASN B C   1 
ATOM   3187 O O   . ASN B 1 25  ? -29.815 -53.450 53.023 1.00 71.16  ? 51  ASN B O   1 
ATOM   3188 C CB  . ASN B 1 25  ? -28.549 -53.267 56.029 1.00 77.61  ? 51  ASN B CB  1 
ATOM   3189 C CG  . ASN B 1 25  ? -29.516 -52.120 55.853 1.00 86.23  ? 51  ASN B CG  1 
ATOM   3190 O OD1 . ASN B 1 25  ? -30.694 -52.222 56.220 1.00 82.98  ? 51  ASN B OD1 1 
ATOM   3191 N ND2 . ASN B 1 25  ? -29.031 -51.020 55.277 1.00 80.16  ? 51  ASN B ND2 1 
ATOM   3192 N N   . SER B 1 26  ? -27.572 -53.564 52.982 1.00 76.05  ? 52  SER B N   1 
ATOM   3193 C CA  . SER B 1 26  ? -27.524 -52.943 51.667 1.00 74.83  ? 52  SER B CA  1 
ATOM   3194 C C   . SER B 1 26  ? -27.906 -53.920 50.565 1.00 78.91  ? 52  SER B C   1 
ATOM   3195 O O   . SER B 1 26  ? -28.447 -53.511 49.531 1.00 76.78  ? 52  SER B O   1 
ATOM   3196 C CB  . SER B 1 26  ? -26.129 -52.370 51.411 1.00 75.31  ? 52  SER B CB  1 
ATOM   3197 O OG  . SER B 1 26  ? -25.907 -51.238 52.237 1.00 80.99  ? 52  SER B OG  1 
ATOM   3198 N N   . LEU B 1 27  ? -27.617 -55.204 50.762 1.00 78.16  ? 53  LEU B N   1 
ATOM   3199 C CA  . LEU B 1 27  ? -28.100 -56.222 49.843 1.00 79.19  ? 53  LEU B CA  1 
ATOM   3200 C C   . LEU B 1 27  ? -29.623 -56.246 49.819 1.00 81.09  ? 53  LEU B C   1 
ATOM   3201 O O   . LEU B 1 27  ? -30.238 -56.304 48.749 1.00 80.84  ? 53  LEU B O   1 
ATOM   3202 C CB  . LEU B 1 27  ? -27.544 -57.588 50.242 1.00 73.56  ? 53  LEU B CB  1 
ATOM   3203 C CG  . LEU B 1 27  ? -27.758 -58.699 49.220 1.00 76.49  ? 53  LEU B CG  1 
ATOM   3204 C CD1 . LEU B 1 27  ? -27.265 -58.238 47.880 1.00 79.86  ? 53  LEU B CD1 1 
ATOM   3205 C CD2 . LEU B 1 27  ? -27.073 -59.997 49.653 1.00 76.00  ? 53  LEU B CD2 1 
ATOM   3206 N N   . VAL B 1 28  ? -30.251 -56.202 50.994 1.00 74.79  ? 54  VAL B N   1 
ATOM   3207 C CA  . VAL B 1 28  ? -31.709 -56.235 51.051 1.00 76.93  ? 54  VAL B CA  1 
ATOM   3208 C C   . VAL B 1 28  ? -32.303 -55.002 50.382 1.00 81.32  ? 54  VAL B C   1 
ATOM   3209 O O   . VAL B 1 28  ? -33.337 -55.084 49.707 1.00 83.41  ? 54  VAL B O   1 
ATOM   3210 C CB  . VAL B 1 28  ? -32.184 -56.393 52.504 1.00 75.59  ? 54  VAL B CB  1 
ATOM   3211 C CG1 . VAL B 1 28  ? -33.686 -56.103 52.637 1.00 76.39  ? 54  VAL B CG1 1 
ATOM   3212 C CG2 . VAL B 1 28  ? -31.873 -57.796 52.977 1.00 77.24  ? 54  VAL B CG2 1 
ATOM   3213 N N   . LEU B 1 29  ? -31.674 -53.838 50.556 1.00 80.02  ? 55  LEU B N   1 
ATOM   3214 C CA  . LEU B 1 29  ? -32.235 -52.645 49.933 1.00 81.74  ? 55  LEU B CA  1 
ATOM   3215 C C   . LEU B 1 29  ? -32.055 -52.665 48.420 1.00 84.71  ? 55  LEU B C   1 
ATOM   3216 O O   . LEU B 1 29  ? -32.943 -52.210 47.689 1.00 86.12  ? 55  LEU B O   1 
ATOM   3217 C CB  . LEU B 1 29  ? -31.621 -51.380 50.522 1.00 78.37  ? 55  LEU B CB  1 
ATOM   3218 C CG  . LEU B 1 29  ? -32.054 -51.086 51.958 1.00 83.74  ? 55  LEU B CG  1 
ATOM   3219 C CD1 . LEU B 1 29  ? -31.149 -50.028 52.564 1.00 77.30  ? 55  LEU B CD1 1 
ATOM   3220 C CD2 . LEU B 1 29  ? -33.515 -50.658 52.009 1.00 85.69  ? 55  LEU B CD2 1 
ATOM   3221 N N   . ASP B 1 30  ? -30.956 -53.232 47.929 1.00 81.20  ? 56  ASP B N   1 
ATOM   3222 C CA  . ASP B 1 30  ? -30.680 -53.231 46.498 1.00 81.08  ? 56  ASP B CA  1 
ATOM   3223 C C   . ASP B 1 30  ? -31.471 -54.288 45.741 1.00 83.16  ? 56  ASP B C   1 
ATOM   3224 O O   . ASP B 1 30  ? -31.326 -54.381 44.518 1.00 85.87  ? 56  ASP B O   1 
ATOM   3225 C CB  . ASP B 1 30  ? -29.189 -53.453 46.236 1.00 78.82  ? 56  ASP B CB  1 
ATOM   3226 C CG  . ASP B 1 30  ? -28.356 -52.207 46.481 1.00 86.40  ? 56  ASP B CG  1 
ATOM   3227 O OD1 . ASP B 1 30  ? -28.933 -51.094 46.434 1.00 85.51  ? 56  ASP B OD1 1 
ATOM   3228 O OD2 . ASP B 1 30  ? -27.122 -52.341 46.704 1.00 87.74  ? 56  ASP B OD2 1 
ATOM   3229 N N   . LEU B 1 31  ? -32.277 -55.094 46.437 1.00 82.51  ? 57  LEU B N   1 
ATOM   3230 C CA  . LEU B 1 31  ? -33.098 -56.110 45.803 1.00 85.11  ? 57  LEU B CA  1 
ATOM   3231 C C   . LEU B 1 31  ? -34.593 -55.965 46.058 1.00 85.34  ? 57  LEU B C   1 
ATOM   3232 O O   . LEU B 1 31  ? -35.379 -56.491 45.269 1.00 92.13  ? 57  LEU B O   1 
ATOM   3233 C CB  . LEU B 1 31  ? -32.665 -57.516 46.254 1.00 83.45  ? 57  LEU B CB  1 
ATOM   3234 C CG  . LEU B 1 31  ? -31.198 -57.928 46.115 1.00 81.55  ? 57  LEU B CG  1 
ATOM   3235 C CD1 . LEU B 1 31  ? -30.886 -59.043 47.114 1.00 80.94  ? 57  LEU B CD1 1 
ATOM   3236 C CD2 . LEU B 1 31  ? -30.848 -58.360 44.698 1.00 77.48  ? 57  LEU B CD2 1 
ATOM   3237 N N   . ASP B 1 32  ? -35.011 -55.274 47.116 1.00 81.60  ? 58  ASP B N   1 
ATOM   3238 C CA  . ASP B 1 32  ? -36.432 -55.210 47.479 1.00 87.19  ? 58  ASP B CA  1 
ATOM   3239 C C   . ASP B 1 32  ? -37.183 -54.269 46.535 1.00 90.86  ? 58  ASP B C   1 
ATOM   3240 O O   . ASP B 1 32  ? -37.578 -53.157 46.889 1.00 91.75  ? 58  ASP B O   1 
ATOM   3241 C CB  . ASP B 1 32  ? -36.602 -54.776 48.927 1.00 86.32  ? 58  ASP B CB  1 
ATOM   3242 C CG  . ASP B 1 32  ? -37.992 -55.052 49.451 1.00 91.17  ? 58  ASP B CG  1 
ATOM   3243 O OD1 . ASP B 1 32  ? -38.725 -55.820 48.791 1.00 86.95  ? 58  ASP B OD1 1 
ATOM   3244 O OD2 . ASP B 1 32  ? -38.350 -54.510 50.523 1.00 97.14  ? 58  ASP B OD2 1 
ATOM   3245 N N   . PHE B 1 33  ? -37.394 -54.754 45.315 1.00 91.46  ? 59  PHE B N   1 
ATOM   3246 C CA  . PHE B 1 33  ? -38.176 -54.095 44.275 1.00 93.05  ? 59  PHE B CA  1 
ATOM   3247 C C   . PHE B 1 33  ? -38.989 -55.140 43.524 1.00 94.15  ? 59  PHE B C   1 
ATOM   3248 O O   . PHE B 1 33  ? -38.538 -56.282 43.364 1.00 91.77  ? 59  PHE B O   1 
ATOM   3249 C CB  . PHE B 1 33  ? -37.286 -53.329 43.283 1.00 89.28  ? 59  PHE B CB  1 
ATOM   3250 C CG  . PHE B 1 33  ? -36.386 -52.327 43.940 1.00 91.79  ? 59  PHE B CG  1 
ATOM   3251 C CD1 . PHE B 1 33  ? -36.893 -51.118 44.398 1.00 93.20  ? 59  PHE B CD1 1 
ATOM   3252 C CD2 . PHE B 1 33  ? -35.034 -52.591 44.108 1.00 91.27  ? 59  PHE B CD2 1 
ATOM   3253 C CE1 . PHE B 1 33  ? -36.068 -50.185 45.004 1.00 92.57  ? 59  PHE B CE1 1 
ATOM   3254 C CE2 . PHE B 1 33  ? -34.197 -51.660 44.712 1.00 87.85  ? 59  PHE B CE2 1 
ATOM   3255 C CZ  . PHE B 1 33  ? -34.714 -50.457 45.161 1.00 88.72  ? 59  PHE B CZ  1 
ATOM   3256 N N   . PRO B 1 34  ? -40.188 -54.777 43.048 1.00 93.22  ? 60  PRO B N   1 
ATOM   3257 C CA  . PRO B 1 34  ? -41.024 -55.769 42.340 1.00 89.55  ? 60  PRO B CA  1 
ATOM   3258 C C   . PRO B 1 34  ? -40.352 -56.369 41.113 1.00 89.26  ? 60  PRO B C   1 
ATOM   3259 O O   . PRO B 1 34  ? -40.456 -57.582 40.887 1.00 88.85  ? 60  PRO B O   1 
ATOM   3260 C CB  . PRO B 1 34  ? -42.280 -54.964 41.973 1.00 92.50  ? 60  PRO B CB  1 
ATOM   3261 C CG  . PRO B 1 34  ? -42.259 -53.772 42.895 1.00 97.74  ? 60  PRO B CG  1 
ATOM   3262 C CD  . PRO B 1 34  ? -40.814 -53.447 43.084 1.00 91.76  ? 60  PRO B CD  1 
ATOM   3263 N N   . ALA B 1 35  ? -39.659 -55.554 40.314 1.00 87.15  ? 61  ALA B N   1 
ATOM   3264 C CA  . ALA B 1 35  ? -39.019 -56.073 39.108 1.00 88.48  ? 61  ALA B CA  1 
ATOM   3265 C C   . ALA B 1 35  ? -38.021 -57.181 39.437 1.00 91.26  ? 61  ALA B C   1 
ATOM   3266 O O   . ALA B 1 35  ? -38.018 -58.239 38.796 1.00 92.25  ? 61  ALA B O   1 
ATOM   3267 C CB  . ALA B 1 35  ? -38.335 -54.938 38.343 1.00 88.94  ? 61  ALA B CB  1 
ATOM   3268 N N   . LEU B 1 36  ? -37.175 -56.966 40.451 1.00 94.10  ? 62  LEU B N   1 
ATOM   3269 C CA  . LEU B 1 36  ? -36.149 -57.952 40.780 1.00 88.33  ? 62  LEU B CA  1 
ATOM   3270 C C   . LEU B 1 36  ? -36.709 -59.118 41.564 1.00 83.85  ? 62  LEU B C   1 
ATOM   3271 O O   . LEU B 1 36  ? -36.144 -60.212 41.521 1.00 82.53  ? 62  LEU B O   1 
ATOM   3272 C CB  . LEU B 1 36  ? -35.036 -57.315 41.613 1.00 84.96  ? 62  LEU B CB  1 
ATOM   3273 C CG  . LEU B 1 36  ? -34.426 -55.987 41.171 1.00 91.18  ? 62  LEU B CG  1 
ATOM   3274 C CD1 . LEU B 1 36  ? -33.034 -55.829 41.768 1.00 88.50  ? 62  LEU B CD1 1 
ATOM   3275 C CD2 . LEU B 1 36  ? -34.371 -55.879 39.656 1.00 92.02  ? 62  LEU B CD2 1 
ATOM   3276 N N   . ARG B 1 37  ? -37.861 -58.928 42.184 1.00 84.77  ? 63  ARG B N   1 
ATOM   3277 C CA  . ARG B 1 37  ? -38.478 -59.947 43.010 1.00 83.42  ? 63  ARG B CA  1 
ATOM   3278 C C   . ARG B 1 37  ? -39.242 -60.985 42.195 1.00 88.49  ? 63  ARG B C   1 
ATOM   3279 O O   . ARG B 1 37  ? -39.850 -61.886 42.781 1.00 84.17  ? 63  ARG B O   1 
ATOM   3280 C CB  . ARG B 1 37  ? -39.413 -59.246 43.996 1.00 79.33  ? 63  ARG B CB  1 
ATOM   3281 C CG  . ARG B 1 37  ? -39.727 -59.992 45.247 1.00 84.85  ? 63  ARG B CG  1 
ATOM   3282 C CD  . ARG B 1 37  ? -39.481 -59.146 46.487 1.00 82.24  ? 63  ARG B CD  1 
ATOM   3283 N NE  . ARG B 1 37  ? -39.907 -59.870 47.682 1.00 77.38  ? 63  ARG B NE  1 
ATOM   3284 C CZ  . ARG B 1 37  ? -39.849 -59.378 48.912 1.00 86.17  ? 63  ARG B CZ  1 
ATOM   3285 N NH1 . ARG B 1 37  ? -39.378 -58.152 49.118 1.00 90.17  ? 63  ARG B NH1 1 
ATOM   3286 N NH2 . ARG B 1 37  ? -40.267 -60.106 49.938 1.00 89.88  ? 63  ARG B NH2 1 
ATOM   3287 N N   . LYS B 1 38  ? -39.193 -60.917 40.862 1.00 90.38  ? 64  LYS B N   1 
ATOM   3288 C CA  . LYS B 1 38  ? -39.677 -62.028 40.055 1.00 90.83  ? 64  LYS B CA  1 
ATOM   3289 C C   . LYS B 1 38  ? -38.628 -63.119 39.918 1.00 87.43  ? 64  LYS B C   1 
ATOM   3290 O O   . LYS B 1 38  ? -38.976 -64.256 39.595 1.00 88.97  ? 64  LYS B O   1 
ATOM   3291 C CB  . LYS B 1 38  ? -40.163 -61.538 38.683 1.00 91.94  ? 64  LYS B CB  1 
ATOM   3292 C CG  . LYS B 1 38  ? -39.084 -61.154 37.688 1.00 97.04  ? 64  LYS B CG  1 
ATOM   3293 C CD  . LYS B 1 38  ? -39.685 -60.388 36.496 1.00 97.70  ? 64  LYS B CD  1 
ATOM   3294 C CE  . LYS B 1 38  ? -40.752 -61.217 35.765 1.00 99.56  ? 64  LYS B CE  1 
ATOM   3295 N NZ  . LYS B 1 38  ? -40.822 -60.924 34.296 1.00 99.95  ? 64  LYS B NZ  1 
ATOM   3296 N N   . ASN B 1 39  ? -37.356 -62.786 40.127 1.00 85.83  ? 65  ASN B N   1 
ATOM   3297 C CA  . ASN B 1 39  ? -36.335 -63.801 40.365 1.00 84.75  ? 65  ASN B CA  1 
ATOM   3298 C C   . ASN B 1 39  ? -36.646 -64.531 41.673 1.00 82.68  ? 65  ASN B C   1 
ATOM   3299 O O   . ASN B 1 39  ? -36.903 -63.895 42.701 1.00 81.68  ? 65  ASN B O   1 
ATOM   3300 C CB  . ASN B 1 39  ? -34.953 -63.131 40.410 1.00 79.80  ? 65  ASN B CB  1 
ATOM   3301 C CG  . ASN B 1 39  ? -33.812 -64.123 40.550 1.00 77.80  ? 65  ASN B CG  1 
ATOM   3302 O OD1 . ASN B 1 39  ? -33.886 -65.065 41.334 1.00 81.57  ? 65  ASN B OD1 1 
ATOM   3303 N ND2 . ASN B 1 39  ? -32.745 -63.908 39.797 1.00 75.53  ? 65  ASN B ND2 1 
ATOM   3304 N N   . LYS B 1 40  ? -36.624 -65.876 41.636 1.00 79.99  ? 66  LYS B N   1 
ATOM   3305 C CA  . LYS B 1 40  ? -36.999 -66.647 42.826 1.00 80.39  ? 66  LYS B CA  1 
ATOM   3306 C C   . LYS B 1 40  ? -35.856 -66.746 43.840 1.00 78.90  ? 66  LYS B C   1 
ATOM   3307 O O   . LYS B 1 40  ? -36.104 -66.757 45.054 1.00 73.70  ? 66  LYS B O   1 
ATOM   3308 C CB  . LYS B 1 40  ? -37.469 -68.052 42.424 1.00 76.05  ? 66  LYS B CB  1 
ATOM   3309 N N   . ASN B 1 41  ? -34.609 -66.789 43.368 1.00 78.18  ? 67  ASN B N   1 
ATOM   3310 C CA  . ASN B 1 41  ? -33.471 -66.642 44.266 1.00 71.70  ? 67  ASN B CA  1 
ATOM   3311 C C   . ASN B 1 41  ? -33.605 -65.377 45.100 1.00 74.98  ? 67  ASN B C   1 
ATOM   3312 O O   . ASN B 1 41  ? -33.448 -65.400 46.325 1.00 69.55  ? 67  ASN B O   1 
ATOM   3313 C CB  . ASN B 1 41  ? -32.186 -66.593 43.451 1.00 72.32  ? 67  ASN B CB  1 
ATOM   3314 C CG  . ASN B 1 41  ? -31.895 -67.889 42.763 1.00 71.76  ? 67  ASN B CG  1 
ATOM   3315 O OD1 . ASN B 1 41  ? -32.427 -68.928 43.146 1.00 71.82  ? 67  ASN B OD1 1 
ATOM   3316 N ND2 . ASN B 1 41  ? -31.047 -67.845 41.737 1.00 70.97  ? 67  ASN B ND2 1 
ATOM   3317 N N   . ILE B 1 42  ? -33.868 -64.250 44.432 1.00 73.70  ? 68  ILE B N   1 
ATOM   3318 C CA  . ILE B 1 42  ? -33.993 -62.975 45.125 1.00 72.16  ? 68  ILE B CA  1 
ATOM   3319 C C   . ILE B 1 42  ? -35.193 -62.972 46.057 1.00 76.08  ? 68  ILE B C   1 
ATOM   3320 O O   . ILE B 1 42  ? -35.086 -62.592 47.230 1.00 77.82  ? 68  ILE B O   1 
ATOM   3321 C CB  . ILE B 1 42  ? -34.085 -61.826 44.113 1.00 76.68  ? 68  ILE B CB  1 
ATOM   3322 C CG1 . ILE B 1 42  ? -32.730 -61.596 43.461 1.00 73.51  ? 68  ILE B CG1 1 
ATOM   3323 C CG2 . ILE B 1 42  ? -34.603 -60.573 44.798 1.00 79.03  ? 68  ILE B CG2 1 
ATOM   3324 C CD1 . ILE B 1 42  ? -32.798 -60.613 42.326 1.00 79.42  ? 68  ILE B CD1 1 
ATOM   3325 N N   . ASP B 1 43  ? -36.351 -63.416 45.567 1.00 77.10  ? 69  ASP B N   1 
ATOM   3326 C CA  . ASP B 1 43  ? -37.542 -63.292 46.397 1.00 77.87  ? 69  ASP B CA  1 
ATOM   3327 C C   . ASP B 1 43  ? -37.498 -64.237 47.588 1.00 79.18  ? 69  ASP B C   1 
ATOM   3328 O O   . ASP B 1 43  ? -37.890 -63.856 48.697 1.00 76.79  ? 69  ASP B O   1 
ATOM   3329 C CB  . ASP B 1 43  ? -38.804 -63.545 45.572 1.00 82.69  ? 69  ASP B CB  1 
ATOM   3330 C CG  . ASP B 1 43  ? -40.076 -63.417 46.413 1.00 86.77  ? 69  ASP B CG  1 
ATOM   3331 O OD1 . ASP B 1 43  ? -40.247 -62.376 47.101 1.00 85.32  ? 69  ASP B OD1 1 
ATOM   3332 O OD2 . ASP B 1 43  ? -40.882 -64.375 46.429 1.00 86.30  ? 69  ASP B OD2 1 
ATOM   3333 N N   . ASN B 1 44  ? -36.998 -65.460 47.397 1.00 80.12  ? 70  ASN B N   1 
ATOM   3334 C CA  . ASN B 1 44  ? -36.886 -66.367 48.535 1.00 78.12  ? 70  ASN B CA  1 
ATOM   3335 C C   . ASN B 1 44  ? -35.908 -65.837 49.568 1.00 80.35  ? 70  ASN B C   1 
ATOM   3336 O O   . ASN B 1 44  ? -36.101 -66.045 50.771 1.00 81.63  ? 70  ASN B O   1 
ATOM   3337 C CB  . ASN B 1 44  ? -36.478 -67.762 48.071 1.00 81.29  ? 70  ASN B CB  1 
ATOM   3338 C CG  . ASN B 1 44  ? -37.642 -68.536 47.481 1.00 83.27  ? 70  ASN B CG  1 
ATOM   3339 O OD1 . ASN B 1 44  ? -38.801 -68.331 47.867 1.00 82.70  ? 70  ASN B OD1 1 
ATOM   3340 N ND2 . ASN B 1 44  ? -37.344 -69.433 46.550 1.00 74.66  ? 70  ASN B ND2 1 
ATOM   3341 N N   . PHE B 1 45  ? -34.884 -65.107 49.123 1.00 79.96  ? 71  PHE B N   1 
ATOM   3342 C CA  . PHE B 1 45  ? -33.924 -64.526 50.055 1.00 76.27  ? 71  PHE B CA  1 
ATOM   3343 C C   . PHE B 1 45  ? -34.550 -63.390 50.848 1.00 77.74  ? 71  PHE B C   1 
ATOM   3344 O O   . PHE B 1 45  ? -34.344 -63.280 52.063 1.00 74.25  ? 71  PHE B O   1 
ATOM   3345 C CB  . PHE B 1 45  ? -32.697 -64.017 49.299 1.00 71.66  ? 71  PHE B CB  1 
ATOM   3346 C CG  . PHE B 1 45  ? -31.756 -63.213 50.154 1.00 71.85  ? 71  PHE B CG  1 
ATOM   3347 C CD1 . PHE B 1 45  ? -30.889 -63.848 51.048 1.00 71.03  ? 71  PHE B CD1 1 
ATOM   3348 C CD2 . PHE B 1 45  ? -31.740 -61.835 50.082 1.00 74.66  ? 71  PHE B CD2 1 
ATOM   3349 C CE1 . PHE B 1 45  ? -30.015 -63.119 51.841 1.00 74.49  ? 71  PHE B CE1 1 
ATOM   3350 C CE2 . PHE B 1 45  ? -30.865 -61.086 50.881 1.00 81.38  ? 71  PHE B CE2 1 
ATOM   3351 C CZ  . PHE B 1 45  ? -30.002 -61.730 51.762 1.00 76.53  ? 71  PHE B CZ  1 
ATOM   3352 N N   . LEU B 1 46  ? -35.270 -62.497 50.172 1.00 77.40  ? 72  LEU B N   1 
ATOM   3353 C CA  . LEU B 1 46  ? -35.889 -61.399 50.895 1.00 77.25  ? 72  LEU B CA  1 
ATOM   3354 C C   . LEU B 1 46  ? -36.888 -61.927 51.911 1.00 83.36  ? 72  LEU B C   1 
ATOM   3355 O O   . LEU B 1 46  ? -36.977 -61.411 53.029 1.00 82.69  ? 72  LEU B O   1 
ATOM   3356 C CB  . LEU B 1 46  ? -36.551 -60.436 49.914 1.00 81.70  ? 72  LEU B CB  1 
ATOM   3357 C CG  . LEU B 1 46  ? -35.500 -59.697 49.085 1.00 82.92  ? 72  LEU B CG  1 
ATOM   3358 C CD1 . LEU B 1 46  ? -36.137 -58.957 47.934 1.00 80.55  ? 72  LEU B CD1 1 
ATOM   3359 C CD2 . LEU B 1 46  ? -34.732 -58.738 49.990 1.00 84.41  ? 72  LEU B CD2 1 
ATOM   3360 N N   . ASN B 1 47  ? -37.583 -63.015 51.572 1.00 83.96  ? 73  ASN B N   1 
ATOM   3361 C CA  . ASN B 1 47  ? -38.556 -63.588 52.495 1.00 82.10  ? 73  ASN B CA  1 
ATOM   3362 C C   . ASN B 1 47  ? -37.889 -63.990 53.806 1.00 85.41  ? 73  ASN B C   1 
ATOM   3363 O O   . ASN B 1 47  ? -38.409 -63.706 54.895 1.00 85.16  ? 73  ASN B O   1 
ATOM   3364 C CB  . ASN B 1 47  ? -39.255 -64.788 51.848 1.00 85.05  ? 73  ASN B CB  1 
ATOM   3365 C CG  . ASN B 1 47  ? -40.122 -64.396 50.649 1.00 87.15  ? 73  ASN B CG  1 
ATOM   3366 O OD1 . ASN B 1 47  ? -40.521 -63.238 50.499 1.00 86.10  ? 73  ASN B OD1 1 
ATOM   3367 N ND2 . ASN B 1 47  ? -40.416 -65.371 49.792 1.00 83.34  ? 73  ASN B ND2 1 
ATOM   3368 N N   . ARG B 1 48  ? -36.730 -64.657 53.721 1.00 79.89  ? 74  ARG B N   1 
ATOM   3369 C CA  . ARG B 1 48  ? -36.051 -65.093 54.938 1.00 82.61  ? 74  ARG B CA  1 
ATOM   3370 C C   . ARG B 1 48  ? -35.578 -63.901 55.760 1.00 76.99  ? 74  ARG B C   1 
ATOM   3371 O O   . ARG B 1 48  ? -35.671 -63.919 56.992 1.00 81.74  ? 74  ARG B O   1 
ATOM   3372 C CB  . ARG B 1 48  ? -34.874 -66.018 54.603 1.00 79.61  ? 74  ARG B CB  1 
ATOM   3373 C CG  . ARG B 1 48  ? -35.259 -67.308 53.876 1.00 84.31  ? 74  ARG B CG  1 
ATOM   3374 C CD  . ARG B 1 48  ? -34.131 -68.354 53.912 1.00 91.03  ? 74  ARG B CD  1 
ATOM   3375 N NE  . ARG B 1 48  ? -33.153 -68.183 52.833 1.00 89.16  ? 74  ARG B NE  1 
ATOM   3376 C CZ  . ARG B 1 48  ? -31.840 -68.368 52.980 1.00 82.78  ? 74  ARG B CZ  1 
ATOM   3377 N NH1 . ARG B 1 48  ? -31.347 -68.728 54.156 1.00 76.88  ? 74  ARG B NH1 1 
ATOM   3378 N NH2 . ARG B 1 48  ? -31.018 -68.181 51.957 1.00 79.50  ? 74  ARG B NH2 1 
ATOM   3379 N N   . TYR B 1 49  ? -35.138 -62.825 55.099 1.00 76.18  ? 75  TYR B N   1 
ATOM   3380 C CA  . TYR B 1 49  ? -34.354 -61.800 55.778 1.00 79.68  ? 75  TYR B CA  1 
ATOM   3381 C C   . TYR B 1 49  ? -35.028 -60.446 55.919 1.00 83.90  ? 75  TYR B C   1 
ATOM   3382 O O   . TYR B 1 49  ? -34.596 -59.663 56.768 1.00 82.58  ? 75  TYR B O   1 
ATOM   3383 C CB  . TYR B 1 49  ? -33.009 -61.585 55.053 1.00 77.53  ? 75  TYR B CB  1 
ATOM   3384 C CG  . TYR B 1 49  ? -31.996 -62.624 55.448 1.00 75.80  ? 75  TYR B CG  1 
ATOM   3385 C CD1 . TYR B 1 49  ? -31.300 -62.520 56.650 1.00 77.27  ? 75  TYR B CD1 1 
ATOM   3386 C CD2 . TYR B 1 49  ? -31.785 -63.740 54.665 1.00 72.92  ? 75  TYR B CD2 1 
ATOM   3387 C CE1 . TYR B 1 49  ? -30.410 -63.485 57.044 1.00 73.87  ? 75  TYR B CE1 1 
ATOM   3388 C CE2 . TYR B 1 49  ? -30.890 -64.714 55.047 1.00 72.27  ? 75  TYR B CE2 1 
ATOM   3389 C CZ  . TYR B 1 49  ? -30.207 -64.581 56.234 1.00 72.98  ? 75  TYR B CZ  1 
ATOM   3390 O OH  . TYR B 1 49  ? -29.324 -65.555 56.622 1.00 70.96  ? 75  TYR B OH  1 
ATOM   3391 N N   . GLU B 1 50  ? -36.079 -60.149 55.146 1.00 87.50  ? 76  GLU B N   1 
ATOM   3392 C CA  . GLU B 1 50  ? -36.561 -58.771 55.118 1.00 88.58  ? 76  GLU B CA  1 
ATOM   3393 C C   . GLU B 1 50  ? -37.101 -58.332 56.474 1.00 86.64  ? 76  GLU B C   1 
ATOM   3394 O O   . GLU B 1 50  ? -36.990 -57.153 56.828 1.00 86.71  ? 76  GLU B O   1 
ATOM   3395 C CB  . GLU B 1 50  ? -37.617 -58.578 54.022 1.00 90.50  ? 76  GLU B CB  1 
ATOM   3396 C CG  . GLU B 1 50  ? -38.953 -59.274 54.262 1.00 92.68  ? 76  GLU B CG  1 
ATOM   3397 C CD  . GLU B 1 50  ? -39.781 -59.370 52.984 1.00 97.97  ? 76  GLU B CD  1 
ATOM   3398 O OE1 . GLU B 1 50  ? -40.430 -60.420 52.759 1.00 97.42  ? 76  GLU B OE1 1 
ATOM   3399 O OE2 . GLU B 1 50  ? -39.771 -58.395 52.196 1.00 101.48 ? 76  GLU B OE2 1 
ATOM   3400 N N   . LYS B 1 51  ? -37.625 -59.259 57.277 1.00 88.46  ? 77  LYS B N   1 
ATOM   3401 C CA  . LYS B 1 51  ? -38.215 -58.824 58.537 1.00 87.52  ? 77  LYS B CA  1 
ATOM   3402 C C   . LYS B 1 51  ? -37.165 -58.652 59.624 1.00 86.72  ? 77  LYS B C   1 
ATOM   3403 O O   . LYS B 1 51  ? -37.314 -57.783 60.489 1.00 85.84  ? 77  LYS B O   1 
ATOM   3404 C CB  . LYS B 1 51  ? -39.290 -59.815 58.997 1.00 94.11  ? 77  LYS B CB  1 
ATOM   3405 N N   . ILE B 1 52  ? -36.070 -59.410 59.565 1.00 86.94  ? 78  ILE B N   1 
ATOM   3406 C CA  . ILE B 1 52  ? -35.048 -59.228 60.590 1.00 87.41  ? 78  ILE B CA  1 
ATOM   3407 C C   . ILE B 1 52  ? -34.112 -58.081 60.229 1.00 84.98  ? 78  ILE B C   1 
ATOM   3408 O O   . ILE B 1 52  ? -33.623 -57.374 61.121 1.00 83.12  ? 78  ILE B O   1 
ATOM   3409 C CB  . ILE B 1 52  ? -34.281 -60.540 60.831 1.00 85.41  ? 78  ILE B CB  1 
ATOM   3410 C CG1 . ILE B 1 52  ? -33.174 -60.334 61.866 1.00 83.16  ? 78  ILE B CG1 1 
ATOM   3411 C CG2 . ILE B 1 52  ? -33.699 -61.087 59.535 1.00 83.87  ? 78  ILE B CG2 1 
ATOM   3412 C CD1 . ILE B 1 52  ? -32.997 -61.514 62.769 1.00 84.95  ? 78  ILE B CD1 1 
ATOM   3413 N N   . VAL B 1 53  ? -33.874 -57.857 58.932 1.00 82.36  ? 79  VAL B N   1 
ATOM   3414 C CA  . VAL B 1 53  ? -33.065 -56.720 58.502 1.00 80.09  ? 79  VAL B CA  1 
ATOM   3415 C C   . VAL B 1 53  ? -33.757 -55.419 58.865 1.00 82.89  ? 79  VAL B C   1 
ATOM   3416 O O   . VAL B 1 53  ? -33.095 -54.429 59.207 1.00 83.79  ? 79  VAL B O   1 
ATOM   3417 C CB  . VAL B 1 53  ? -32.763 -56.822 56.989 1.00 80.01  ? 79  VAL B CB  1 
ATOM   3418 C CG1 . VAL B 1 53  ? -32.127 -55.546 56.456 1.00 76.08  ? 79  VAL B CG1 1 
ATOM   3419 C CG2 . VAL B 1 53  ? -31.865 -58.016 56.709 1.00 78.89  ? 79  VAL B CG2 1 
ATOM   3420 N N   . LYS B 1 54  ? -35.096 -55.399 58.824 1.00 81.86  ? 80  LYS B N   1 
ATOM   3421 C CA  . LYS B 1 54  ? -35.827 -54.201 59.225 1.00 83.69  ? 80  LYS B CA  1 
ATOM   3422 C C   . LYS B 1 54  ? -35.741 -53.970 60.729 1.00 84.52  ? 80  LYS B C   1 
ATOM   3423 O O   . LYS B 1 54  ? -35.721 -52.818 61.179 1.00 85.63  ? 80  LYS B O   1 
ATOM   3424 C CB  . LYS B 1 54  ? -37.288 -54.288 58.781 1.00 83.22  ? 80  LYS B CB  1 
ATOM   3425 N N   . LYS B 1 55  ? -35.643 -55.035 61.525 1.00 84.10  ? 81  LYS B N   1 
ATOM   3426 C CA  . LYS B 1 55  ? -35.518 -54.828 62.964 1.00 84.15  ? 81  LYS B CA  1 
ATOM   3427 C C   . LYS B 1 55  ? -34.156 -54.238 63.306 1.00 83.33  ? 81  LYS B C   1 
ATOM   3428 O O   . LYS B 1 55  ? -34.061 -53.328 64.140 1.00 83.30  ? 81  LYS B O   1 
ATOM   3429 C CB  . LYS B 1 55  ? -35.745 -56.138 63.724 1.00 87.91  ? 81  LYS B CB  1 
ATOM   3430 C CG  . LYS B 1 55  ? -37.177 -56.668 63.637 1.00 92.85  ? 81  LYS B CG  1 
ATOM   3431 C CD  . LYS B 1 55  ? -37.548 -57.545 64.824 1.00 92.44  ? 81  LYS B CD  1 
ATOM   3432 C CE  . LYS B 1 55  ? -36.461 -58.565 65.130 1.00 94.82  ? 81  LYS B CE  1 
ATOM   3433 N NZ  . LYS B 1 55  ? -36.910 -59.524 66.176 1.00 98.30  ? 81  LYS B NZ  1 
ATOM   3434 N N   . ILE B 1 56  ? -33.092 -54.721 62.653 1.00 82.28  ? 82  ILE B N   1 
ATOM   3435 C CA  . ILE B 1 56  ? -31.766 -54.186 62.949 1.00 81.22  ? 82  ILE B CA  1 
ATOM   3436 C C   . ILE B 1 56  ? -31.629 -52.771 62.401 1.00 81.79  ? 82  ILE B C   1 
ATOM   3437 O O   . ILE B 1 56  ? -30.902 -51.947 62.970 1.00 79.54  ? 82  ILE B O   1 
ATOM   3438 C CB  . ILE B 1 56  ? -30.655 -55.115 62.406 1.00 79.75  ? 82  ILE B CB  1 
ATOM   3439 C CG1 . ILE B 1 56  ? -30.502 -55.002 60.893 1.00 86.02  ? 82  ILE B CG1 1 
ATOM   3440 C CG2 . ILE B 1 56  ? -30.930 -56.571 62.761 1.00 84.27  ? 82  ILE B CG2 1 
ATOM   3441 C CD1 . ILE B 1 56  ? -29.557 -53.891 60.443 1.00 85.06  ? 82  ILE B CD1 1 
ATOM   3442 N N   . ARG B 1 57  ? -32.323 -52.454 61.301 1.00 83.62  ? 83  ARG B N   1 
ATOM   3443 C CA  . ARG B 1 57  ? -32.304 -51.085 60.797 1.00 84.00  ? 83  ARG B CA  1 
ATOM   3444 C C   . ARG B 1 57  ? -32.872 -50.111 61.815 1.00 81.40  ? 83  ARG B C   1 
ATOM   3445 O O   . ARG B 1 57  ? -32.425 -48.960 61.891 1.00 83.85  ? 83  ARG B O   1 
ATOM   3446 C CB  . ARG B 1 57  ? -33.056 -50.989 59.472 1.00 84.29  ? 83  ARG B CB  1 
ATOM   3447 C CG  . ARG B 1 57  ? -32.614 -49.811 58.621 1.00 85.01  ? 83  ARG B CG  1 
ATOM   3448 C CD  . ARG B 1 57  ? -33.429 -49.699 57.325 1.00 82.30  ? 83  ARG B CD  1 
ATOM   3449 N NE  . ARG B 1 57  ? -33.246 -50.865 56.473 1.00 82.38  ? 83  ARG B NE  1 
ATOM   3450 C CZ  . ARG B 1 57  ? -34.159 -51.334 55.629 1.00 88.22  ? 83  ARG B CZ  1 
ATOM   3451 N NH1 . ARG B 1 57  ? -35.338 -50.738 55.515 1.00 92.39  ? 83  ARG B NH1 1 
ATOM   3452 N NH2 . ARG B 1 57  ? -33.890 -52.408 54.898 1.00 89.05  ? 83  ARG B NH2 1 
ATOM   3453 N N   . GLY B 1 58  ? -33.829 -50.562 62.626 1.00 79.80  ? 84  GLY B N   1 
ATOM   3454 C CA  . GLY B 1 58  ? -34.380 -49.708 63.664 1.00 82.77  ? 84  GLY B CA  1 
ATOM   3455 C C   . GLY B 1 58  ? -33.414 -49.424 64.800 1.00 80.38  ? 84  GLY B C   1 
ATOM   3456 O O   . GLY B 1 58  ? -33.473 -48.356 65.420 1.00 74.49  ? 84  GLY B O   1 
ATOM   3457 N N   . LEU B 1 59  ? -32.530 -50.371 65.104 1.00 78.83  ? 85  LEU B N   1 
ATOM   3458 C CA  . LEU B 1 59  ? -31.553 -50.180 66.169 1.00 79.81  ? 85  LEU B CA  1 
ATOM   3459 C C   . LEU B 1 59  ? -30.354 -49.333 65.736 1.00 79.69  ? 85  LEU B C   1 
ATOM   3460 O O   . LEU B 1 59  ? -29.506 -49.001 66.576 1.00 77.31  ? 85  LEU B O   1 
ATOM   3461 C CB  . LEU B 1 59  ? -31.104 -51.544 66.701 1.00 78.72  ? 85  LEU B CB  1 
ATOM   3462 C CG  . LEU B 1 59  ? -32.264 -52.412 67.225 1.00 84.18  ? 85  LEU B CG  1 
ATOM   3463 C CD1 . LEU B 1 59  ? -31.823 -53.850 67.479 1.00 86.57  ? 85  LEU B CD1 1 
ATOM   3464 C CD2 . LEU B 1 59  ? -32.882 -51.813 68.485 1.00 80.69  ? 85  LEU B CD2 1 
ATOM   3465 N N   . GLN B 1 60  ? -30.252 -48.988 64.454 1.00 79.39  ? 86  GLN B N   1 
ATOM   3466 C CA  . GLN B 1 60  ? -29.136 -48.191 63.962 1.00 76.81  ? 86  GLN B CA  1 
ATOM   3467 C C   . GLN B 1 60  ? -29.305 -46.723 64.342 1.00 72.40  ? 86  GLN B C   1 
ATOM   3468 O O   . GLN B 1 60  ? -30.419 -46.231 64.547 1.00 75.04  ? 86  GLN B O   1 
ATOM   3469 C CB  . GLN B 1 60  ? -29.029 -48.306 62.429 1.00 76.68  ? 86  GLN B CB  1 
ATOM   3470 C CG  . GLN B 1 60  ? -28.529 -49.662 61.891 1.00 78.68  ? 86  GLN B CG  1 
ATOM   3471 C CD  . GLN B 1 60  ? -27.113 -50.002 62.351 1.00 84.45  ? 86  GLN B CD  1 
ATOM   3472 O OE1 . GLN B 1 60  ? -26.137 -49.502 61.790 1.00 82.34  ? 86  GLN B OE1 1 
ATOM   3473 N NE2 . GLN B 1 60  ? -26.997 -50.850 63.381 1.00 84.96  ? 86  GLN B NE2 1 
ATOM   3474 N N   . MET B 1 61  ? -28.178 -46.029 64.467 1.00 71.75  ? 87  MET B N   1 
ATOM   3475 C CA  . MET B 1 61  ? -28.214 -44.585 64.648 1.00 68.76  ? 87  MET B CA  1 
ATOM   3476 C C   . MET B 1 61  ? -28.817 -43.934 63.405 1.00 67.53  ? 87  MET B C   1 
ATOM   3477 O O   . MET B 1 61  ? -28.631 -44.413 62.283 1.00 65.23  ? 87  MET B O   1 
ATOM   3478 C CB  . MET B 1 61  ? -26.813 -44.048 64.922 1.00 67.56  ? 87  MET B CB  1 
ATOM   3479 C CG  . MET B 1 61  ? -26.772 -42.552 65.177 1.00 66.49  ? 87  MET B CG  1 
ATOM   3480 S SD  . MET B 1 61  ? -25.155 -42.031 65.789 1.00 63.50  ? 87  MET B SD  1 
ATOM   3481 C CE  . MET B 1 61  ? -25.258 -42.725 67.456 1.00 62.52  ? 87  MET B CE  1 
ATOM   3482 N N   . LYS B 1 62  ? -29.571 -42.857 63.611 1.00 68.16  ? 88  LYS B N   1 
ATOM   3483 C CA  . LYS B 1 62  ? -30.345 -42.234 62.549 1.00 66.62  ? 88  LYS B CA  1 
ATOM   3484 C C   . LYS B 1 62  ? -30.240 -40.722 62.633 1.00 69.66  ? 88  LYS B C   1 
ATOM   3485 O O   . LYS B 1 62  ? -29.982 -40.150 63.696 1.00 66.35  ? 88  LYS B O   1 
ATOM   3486 C CB  . LYS B 1 62  ? -31.841 -42.573 62.630 1.00 70.57  ? 88  LYS B CB  1 
ATOM   3487 C CG  . LYS B 1 62  ? -32.188 -44.000 62.921 1.00 74.59  ? 88  LYS B CG  1 
ATOM   3488 C CD  . LYS B 1 62  ? -33.654 -44.112 63.288 1.00 77.77  ? 88  LYS B CD  1 
ATOM   3489 C CE  . LYS B 1 62  ? -34.110 -45.566 63.248 1.00 82.66  ? 88  LYS B CE  1 
ATOM   3490 N NZ  . LYS B 1 62  ? -33.754 -46.218 61.954 1.00 81.31  ? 88  LYS B NZ  1 
ATOM   3491 N N   . ALA B 1 63  ? -30.483 -40.075 61.486 1.00 70.59  ? 89  ALA B N   1 
ATOM   3492 C CA  . ALA B 1 63  ? -30.486 -38.618 61.453 1.00 65.74  ? 89  ALA B CA  1 
ATOM   3493 C C   . ALA B 1 63  ? -31.500 -38.066 62.443 1.00 65.82  ? 89  ALA B C   1 
ATOM   3494 O O   . ALA B 1 63  ? -31.269 -37.018 63.058 1.00 65.53  ? 89  ALA B O   1 
ATOM   3495 C CB  . ALA B 1 63  ? -30.787 -38.127 60.034 1.00 69.15  ? 89  ALA B CB  1 
ATOM   3496 N N   . GLU B 1 64  ? -32.599 -38.793 62.655 1.00 65.45  ? 90  GLU B N   1 
ATOM   3497 C CA  . GLU B 1 64  ? -33.654 -38.324 63.540 1.00 72.56  ? 90  GLU B CA  1 
ATOM   3498 C C   . GLU B 1 64  ? -33.250 -38.373 65.004 1.00 68.42  ? 90  GLU B C   1 
ATOM   3499 O O   . GLU B 1 64  ? -34.004 -37.886 65.850 1.00 66.44  ? 90  GLU B O   1 
ATOM   3500 C CB  . GLU B 1 64  ? -34.924 -39.158 63.357 1.00 72.93  ? 90  GLU B CB  1 
ATOM   3501 C CG  . GLU B 1 64  ? -35.477 -39.181 61.929 1.00 80.47  ? 90  GLU B CG  1 
ATOM   3502 C CD  . GLU B 1 64  ? -35.008 -40.386 61.108 1.00 84.53  ? 90  GLU B CD  1 
ATOM   3503 O OE1 . GLU B 1 64  ? -35.844 -41.301 60.889 1.00 88.31  ? 90  GLU B OE1 1 
ATOM   3504 O OE2 . GLU B 1 64  ? -33.829 -40.413 60.663 1.00 78.14  ? 90  GLU B OE2 1 
ATOM   3505 N N   . ASP B 1 65  ? -32.092 -38.944 65.329 1.00 69.16  ? 91  ASP B N   1 
ATOM   3506 C CA  . ASP B 1 65  ? -31.592 -38.863 66.695 1.00 67.48  ? 91  ASP B CA  1 
ATOM   3507 C C   . ASP B 1 65  ? -30.991 -37.503 67.020 1.00 61.88  ? 91  ASP B C   1 
ATOM   3508 O O   . ASP B 1 65  ? -30.614 -37.282 68.174 1.00 61.59  ? 91  ASP B O   1 
ATOM   3509 C CB  . ASP B 1 65  ? -30.548 -39.967 66.952 1.00 66.76  ? 91  ASP B CB  1 
ATOM   3510 C CG  . ASP B 1 65  ? -31.120 -41.380 66.777 1.00 69.26  ? 91  ASP B CG  1 
ATOM   3511 O OD1 . ASP B 1 65  ? -32.348 -41.560 66.915 1.00 70.31  ? 91  ASP B OD1 1 
ATOM   3512 O OD2 . ASP B 1 65  ? -30.348 -42.309 66.466 1.00 70.90  ? 91  ASP B OD2 1 
ATOM   3513 N N   . TYR B 1 66  ? -30.922 -36.576 66.053 1.00 64.24  ? 92  TYR B N   1 
ATOM   3514 C CA  . TYR B 1 66  ? -30.243 -35.297 66.256 1.00 64.36  ? 92  TYR B CA  1 
ATOM   3515 C C   . TYR B 1 66  ? -31.156 -34.124 65.922 1.00 67.72  ? 92  TYR B C   1 
ATOM   3516 O O   . TYR B 1 66  ? -31.970 -34.210 65.002 1.00 68.40  ? 92  TYR B O   1 
ATOM   3517 C CB  . TYR B 1 66  ? -28.970 -35.202 65.414 1.00 62.05  ? 92  TYR B CB  1 
ATOM   3518 C CG  . TYR B 1 66  ? -27.917 -36.229 65.771 1.00 62.25  ? 92  TYR B CG  1 
ATOM   3519 C CD1 . TYR B 1 66  ? -27.984 -37.515 65.256 1.00 62.66  ? 92  TYR B CD1 1 
ATOM   3520 C CD2 . TYR B 1 66  ? -26.851 -35.910 66.622 1.00 58.21  ? 92  TYR B CD2 1 
ATOM   3521 C CE1 . TYR B 1 66  ? -27.014 -38.462 65.558 1.00 61.55  ? 92  TYR B CE1 1 
ATOM   3522 C CE2 . TYR B 1 66  ? -25.870 -36.848 66.930 1.00 56.66  ? 92  TYR B CE2 1 
ATOM   3523 C CZ  . TYR B 1 66  ? -25.965 -38.127 66.402 1.00 62.10  ? 92  TYR B CZ  1 
ATOM   3524 O OH  . TYR B 1 66  ? -25.024 -39.090 66.709 1.00 55.74  ? 92  TYR B OH  1 
ATOM   3525 N N   . ASP B 1 67  ? -31.039 -33.048 66.712 1.00 70.21  ? 93  ASP B N   1 
ATOM   3526 C CA  . ASP B 1 67  ? -31.570 -31.724 66.376 1.00 69.70  ? 93  ASP B CA  1 
ATOM   3527 C C   . ASP B 1 67  ? -30.584 -30.998 65.467 1.00 71.73  ? 93  ASP B C   1 
ATOM   3528 O O   . ASP B 1 67  ? -29.408 -30.838 65.827 1.00 69.65  ? 93  ASP B O   1 
ATOM   3529 C CB  . ASP B 1 67  ? -31.776 -30.870 67.629 1.00 71.05  ? 93  ASP B CB  1 
ATOM   3530 C CG  . ASP B 1 67  ? -32.926 -31.341 68.492 1.00 73.72  ? 93  ASP B CG  1 
ATOM   3531 O OD1 . ASP B 1 67  ? -33.934 -31.843 67.930 1.00 78.60  ? 93  ASP B OD1 1 
ATOM   3532 O OD2 . ASP B 1 67  ? -32.812 -31.194 69.737 1.00 71.61  ? 93  ASP B OD2 1 
ATOM   3533 N N   . VAL B 1 68  ? -31.050 -30.546 64.305 1.00 71.75  ? 94  VAL B N   1 
ATOM   3534 C CA  . VAL B 1 68  ? -30.240 -29.691 63.441 1.00 70.01  ? 94  VAL B CA  1 
ATOM   3535 C C   . VAL B 1 68  ? -30.363 -28.256 63.941 1.00 73.25  ? 94  VAL B C   1 
ATOM   3536 O O   . VAL B 1 68  ? -31.466 -27.704 64.001 1.00 75.95  ? 94  VAL B O   1 
ATOM   3537 C CB  . VAL B 1 68  ? -30.665 -29.813 61.971 1.00 73.77  ? 94  VAL B CB  1 
ATOM   3538 C CG1 . VAL B 1 68  ? -29.802 -28.920 61.090 1.00 71.63  ? 94  VAL B CG1 1 
ATOM   3539 C CG2 . VAL B 1 68  ? -30.568 -31.271 61.512 1.00 74.15  ? 94  VAL B CG2 1 
ATOM   3540 N N   . VAL B 1 69  ? -29.238 -27.656 64.319 1.00 71.06  ? 95  VAL B N   1 
ATOM   3541 C CA  . VAL B 1 69  ? -29.231 -26.311 64.889 1.00 70.29  ? 95  VAL B CA  1 
ATOM   3542 C C   . VAL B 1 69  ? -29.022 -25.232 63.818 1.00 72.28  ? 95  VAL B C   1 
ATOM   3543 O O   . VAL B 1 69  ? -29.687 -24.192 63.837 1.00 78.24  ? 95  VAL B O   1 
ATOM   3544 C CB  . VAL B 1 69  ? -28.141 -26.264 65.984 1.00 70.39  ? 95  VAL B CB  1 
ATOM   3545 C CG1 . VAL B 1 69  ? -27.989 -24.870 66.611 1.00 67.91  ? 95  VAL B CG1 1 
ATOM   3546 C CG2 . VAL B 1 69  ? -28.448 -27.298 67.050 1.00 68.51  ? 95  VAL B CG2 1 
ATOM   3547 N N   . LYS B 1 70  ? -28.136 -25.484 62.859 1.00 68.17  ? 96  LYS B N   1 
ATOM   3548 C CA  . LYS B 1 70  ? -27.591 -24.543 61.882 1.00 68.28  ? 96  LYS B CA  1 
ATOM   3549 C C   . LYS B 1 70  ? -26.788 -25.300 60.832 1.00 72.14  ? 96  LYS B C   1 
ATOM   3550 O O   . LYS B 1 70  ? -26.031 -26.214 61.168 1.00 69.35  ? 96  LYS B O   1 
ATOM   3551 C CB  . LYS B 1 70  ? -26.661 -23.532 62.596 1.00 68.38  ? 96  LYS B CB  1 
ATOM   3552 C CG  . LYS B 1 70  ? -25.754 -22.702 61.663 1.00 78.98  ? 96  LYS B CG  1 
ATOM   3553 C CD  . LYS B 1 70  ? -24.966 -21.511 62.227 1.00 89.07  ? 96  LYS B CD  1 
ATOM   3554 C CE  . LYS B 1 70  ? -25.325 -20.108 61.844 1.00 90.74  ? 96  LYS B CE  1 
ATOM   3555 N NZ  . LYS B 1 70  ? -23.905 -19.608 61.457 1.00 85.50  ? 96  LYS B NZ  1 
ATOM   3556 N N   . VAL B 1 71  ? -26.864 -24.847 59.583 1.00 63.21  ? 97  VAL B N   1 
ATOM   3557 C CA  . VAL B 1 71  ? -25.927 -25.333 58.583 1.00 67.04  ? 97  VAL B CA  1 
ATOM   3558 C C   . VAL B 1 71  ? -24.694 -24.440 58.659 1.00 69.29  ? 97  VAL B C   1 
ATOM   3559 O O   . VAL B 1 71  ? -24.821 -23.211 58.706 1.00 74.91  ? 97  VAL B O   1 
ATOM   3560 C CB  . VAL B 1 71  ? -26.560 -25.318 57.182 1.00 66.68  ? 97  VAL B CB  1 
ATOM   3561 C CG1 . VAL B 1 71  ? -25.601 -25.839 56.167 1.00 67.29  ? 97  VAL B CG1 1 
ATOM   3562 C CG2 . VAL B 1 71  ? -27.828 -26.158 57.177 1.00 69.38  ? 97  VAL B CG2 1 
ATOM   3563 N N   . ILE B 1 72  ? -23.502 -25.043 58.749 1.00 67.35  ? 98  ILE B N   1 
ATOM   3564 C CA  . ILE B 1 72  ? -22.262 -24.301 58.972 1.00 66.81  ? 98  ILE B CA  1 
ATOM   3565 C C   . ILE B 1 72  ? -21.191 -24.595 57.934 1.00 65.90  ? 98  ILE B C   1 
ATOM   3566 O O   . ILE B 1 72  ? -20.109 -24.011 57.995 1.00 63.64  ? 98  ILE B O   1 
ATOM   3567 C CB  . ILE B 1 72  ? -21.691 -24.555 60.386 1.00 67.67  ? 98  ILE B CB  1 
ATOM   3568 C CG1 . ILE B 1 72  ? -21.321 -26.017 60.607 1.00 66.56  ? 98  ILE B CG1 1 
ATOM   3569 C CG2 . ILE B 1 72  ? -22.648 -24.148 61.456 1.00 65.76  ? 98  ILE B CG2 1 
ATOM   3570 C CD1 . ILE B 1 72  ? -20.834 -26.285 62.034 1.00 63.45  ? 98  ILE B CD1 1 
ATOM   3571 N N   . GLY B 1 73  ? -21.453 -25.484 56.989 1.00 69.52  ? 99  GLY B N   1 
ATOM   3572 C CA  . GLY B 1 73  ? -20.499 -25.804 55.945 1.00 65.71  ? 99  GLY B CA  1 
ATOM   3573 C C   . GLY B 1 73  ? -21.234 -26.449 54.794 1.00 70.71  ? 99  GLY B C   1 
ATOM   3574 O O   . GLY B 1 73  ? -22.326 -27.007 54.967 1.00 69.21  ? 99  GLY B O   1 
ATOM   3575 N N   . ARG B 1 74  ? -20.665 -26.317 53.600 1.00 71.46  ? 100 ARG B N   1 
ATOM   3576 C CA  . ARG B 1 74  ? -21.244 -26.918 52.412 1.00 71.74  ? 100 ARG B CA  1 
ATOM   3577 C C   . ARG B 1 74  ? -20.105 -27.454 51.561 1.00 71.75  ? 100 ARG B C   1 
ATOM   3578 O O   . ARG B 1 74  ? -18.969 -26.977 51.639 1.00 65.26  ? 100 ARG B O   1 
ATOM   3579 C CB  . ARG B 1 74  ? -22.130 -25.932 51.621 1.00 68.65  ? 100 ARG B CB  1 
ATOM   3580 N N   . GLY B 1 75  ? -20.413 -28.483 50.781 1.00 71.38  ? 101 GLY B N   1 
ATOM   3581 C CA  . GLY B 1 75  ? -19.449 -29.073 49.870 1.00 72.24  ? 101 GLY B CA  1 
ATOM   3582 C C   . GLY B 1 75  ? -20.131 -29.561 48.609 1.00 73.86  ? 101 GLY B C   1 
ATOM   3583 O O   . GLY B 1 75  ? -21.340 -29.347 48.424 1.00 74.21  ? 101 GLY B O   1 
ATOM   3584 N N   . ALA B 1 76  ? -19.367 -30.221 47.736 1.00 76.67  ? 102 ALA B N   1 
ATOM   3585 C CA  . ALA B 1 76  ? -19.925 -30.682 46.466 1.00 79.39  ? 102 ALA B CA  1 
ATOM   3586 C C   . ALA B 1 76  ? -21.123 -31.605 46.679 1.00 82.28  ? 102 ALA B C   1 
ATOM   3587 O O   . ALA B 1 76  ? -22.160 -31.460 46.019 1.00 78.45  ? 102 ALA B O   1 
ATOM   3588 C CB  . ALA B 1 76  ? -18.841 -31.391 45.660 1.00 74.87  ? 102 ALA B CB  1 
ATOM   3589 N N   . PHE B 1 77  ? -21.023 -32.529 47.632 1.00 79.83  ? 103 PHE B N   1 
ATOM   3590 C CA  . PHE B 1 77  ? -22.014 -33.584 47.767 1.00 80.29  ? 103 PHE B CA  1 
ATOM   3591 C C   . PHE B 1 77  ? -22.853 -33.484 49.033 1.00 75.79  ? 103 PHE B C   1 
ATOM   3592 O O   . PHE B 1 77  ? -23.663 -34.384 49.286 1.00 75.40  ? 103 PHE B O   1 
ATOM   3593 C CB  . PHE B 1 77  ? -21.313 -34.939 47.689 1.00 80.45  ? 103 PHE B CB  1 
ATOM   3594 C CG  . PHE B 1 77  ? -20.594 -35.161 46.387 1.00 84.95  ? 103 PHE B CG  1 
ATOM   3595 C CD1 . PHE B 1 77  ? -21.310 -35.285 45.195 1.00 86.63  ? 103 PHE B CD1 1 
ATOM   3596 C CD2 . PHE B 1 77  ? -19.201 -35.215 46.344 1.00 83.35  ? 103 PHE B CD2 1 
ATOM   3597 C CE1 . PHE B 1 77  ? -20.645 -35.480 43.985 1.00 89.22  ? 103 PHE B CE1 1 
ATOM   3598 C CE2 . PHE B 1 77  ? -18.528 -35.410 45.137 1.00 86.28  ? 103 PHE B CE2 1 
ATOM   3599 C CZ  . PHE B 1 77  ? -19.250 -35.543 43.956 1.00 83.79  ? 103 PHE B CZ  1 
ATOM   3600 N N   . GLY B 1 78  ? -22.703 -32.416 49.820 1.00 72.99  ? 104 GLY B N   1 
ATOM   3601 C CA  . GLY B 1 78  ? -23.521 -32.281 51.018 1.00 71.24  ? 104 GLY B CA  1 
ATOM   3602 C C   . GLY B 1 78  ? -23.150 -31.071 51.863 1.00 71.11  ? 104 GLY B C   1 
ATOM   3603 O O   . GLY B 1 78  ? -22.652 -30.062 51.354 1.00 74.13  ? 104 GLY B O   1 
ATOM   3604 N N   . GLU B 1 79  ? -23.401 -31.188 53.161 1.00 71.37  ? 105 GLU B N   1 
ATOM   3605 C CA  . GLU B 1 79  ? -23.239 -30.050 54.051 1.00 72.66  ? 105 GLU B CA  1 
ATOM   3606 C C   . GLU B 1 79  ? -22.787 -30.522 55.431 1.00 73.79  ? 105 GLU B C   1 
ATOM   3607 O O   . GLU B 1 79  ? -22.829 -31.715 55.759 1.00 68.42  ? 105 GLU B O   1 
ATOM   3608 C CB  . GLU B 1 79  ? -24.542 -29.255 54.132 1.00 71.38  ? 105 GLU B CB  1 
ATOM   3609 C CG  . GLU B 1 79  ? -25.757 -30.134 54.293 1.00 70.20  ? 105 GLU B CG  1 
ATOM   3610 C CD  . GLU B 1 79  ? -27.043 -29.339 54.294 1.00 82.23  ? 105 GLU B CD  1 
ATOM   3611 O OE1 . GLU B 1 79  ? -27.918 -29.619 55.146 1.00 78.88  ? 105 GLU B OE1 1 
ATOM   3612 O OE2 . GLU B 1 79  ? -27.176 -28.430 53.440 1.00 90.40  ? 105 GLU B OE2 1 
ATOM   3613 N N   . VAL B 1 80  ? -22.346 -29.561 56.240 1.00 70.82  ? 106 VAL B N   1 
ATOM   3614 C CA  . VAL B 1 80  ? -22.014 -29.794 57.636 1.00 66.02  ? 106 VAL B CA  1 
ATOM   3615 C C   . VAL B 1 80  ? -23.041 -29.061 58.478 1.00 67.76  ? 106 VAL B C   1 
ATOM   3616 O O   . VAL B 1 80  ? -23.277 -27.864 58.277 1.00 67.22  ? 106 VAL B O   1 
ATOM   3617 C CB  . VAL B 1 80  ? -20.588 -29.337 57.989 1.00 67.46  ? 106 VAL B CB  1 
ATOM   3618 C CG1 . VAL B 1 80  ? -20.329 -29.556 59.493 1.00 61.81  ? 106 VAL B CG1 1 
ATOM   3619 C CG2 . VAL B 1 80  ? -19.567 -30.089 57.166 1.00 60.38  ? 106 VAL B CG2 1 
ATOM   3620 N N   . GLN B 1 81  ? -23.668 -29.787 59.401 1.00 62.41  ? 107 GLN B N   1 
ATOM   3621 C CA  . GLN B 1 81  ? -24.655 -29.230 60.308 1.00 67.46  ? 107 GLN B CA  1 
ATOM   3622 C C   . GLN B 1 81  ? -24.104 -29.230 61.727 1.00 66.56  ? 107 GLN B C   1 
ATOM   3623 O O   . GLN B 1 81  ? -23.414 -30.169 62.146 1.00 65.79  ? 107 GLN B O   1 
ATOM   3624 C CB  . GLN B 1 81  ? -25.966 -30.020 60.274 1.00 67.81  ? 107 GLN B CB  1 
ATOM   3625 C CG  . GLN B 1 81  ? -26.489 -30.329 58.883 1.00 69.44  ? 107 GLN B CG  1 
ATOM   3626 C CD  . GLN B 1 81  ? -27.760 -31.149 58.931 1.00 75.07  ? 107 GLN B CD  1 
ATOM   3627 O OE1 . GLN B 1 81  ? -27.865 -32.111 59.697 1.00 74.89  ? 107 GLN B OE1 1 
ATOM   3628 N NE2 . GLN B 1 81  ? -28.758 -30.742 58.151 1.00 71.51  ? 107 GLN B NE2 1 
ATOM   3629 N N   . LEU B 1 82  ? -24.391 -28.157 62.443 1.00 60.88  ? 108 LEU B N   1 
ATOM   3630 C CA  . LEU B 1 82  ? -24.258 -28.128 63.887 1.00 61.46  ? 108 LEU B CA  1 
ATOM   3631 C C   . LEU B 1 82  ? -25.458 -28.873 64.457 1.00 67.99  ? 108 LEU B C   1 
ATOM   3632 O O   . LEU B 1 82  ? -26.605 -28.537 64.130 1.00 64.56  ? 108 LEU B O   1 
ATOM   3633 C CB  . LEU B 1 82  ? -24.213 -26.685 64.379 1.00 59.67  ? 108 LEU B CB  1 
ATOM   3634 C CG  . LEU B 1 82  ? -23.946 -26.466 65.861 1.00 63.02  ? 108 LEU B CG  1 
ATOM   3635 C CD1 . LEU B 1 82  ? -22.575 -27.011 66.256 1.00 58.55  ? 108 LEU B CD1 1 
ATOM   3636 C CD2 . LEU B 1 82  ? -24.016 -24.989 66.128 1.00 64.68  ? 108 LEU B CD2 1 
ATOM   3637 N N   . VAL B 1 83  ? -25.206 -29.920 65.254 1.00 61.35  ? 109 VAL B N   1 
ATOM   3638 C CA  . VAL B 1 83  ? -26.288 -30.770 65.743 1.00 62.13  ? 109 VAL B CA  1 
ATOM   3639 C C   . VAL B 1 83  ? -26.167 -31.007 67.246 1.00 63.79  ? 109 VAL B C   1 
ATOM   3640 O O   . VAL B 1 83  ? -25.088 -30.931 67.844 1.00 59.40  ? 109 VAL B O   1 
ATOM   3641 C CB  . VAL B 1 83  ? -26.337 -32.134 65.022 1.00 63.90  ? 109 VAL B CB  1 
ATOM   3642 C CG1 . VAL B 1 83  ? -26.753 -31.957 63.557 1.00 68.47  ? 109 VAL B CG1 1 
ATOM   3643 C CG2 . VAL B 1 83  ? -24.991 -32.880 65.162 1.00 60.79  ? 109 VAL B CG2 1 
ATOM   3644 N N   A ARG B 1 84  ? -27.308 -31.332 67.841 0.49 63.95  ? 110 ARG B N   1 
ATOM   3645 N N   B ARG B 1 84  ? -27.306 -31.294 67.861 0.51 63.34  ? 110 ARG B N   1 
ATOM   3646 C CA  A ARG B 1 84  ? -27.432 -31.658 69.253 0.49 63.79  ? 110 ARG B CA  1 
ATOM   3647 C CA  B ARG B 1 84  ? -27.365 -31.672 69.262 0.51 63.27  ? 110 ARG B CA  1 
ATOM   3648 C C   A ARG B 1 84  ? -28.050 -33.044 69.329 0.49 63.70  ? 110 ARG B C   1 
ATOM   3649 C C   B ARG B 1 84  ? -28.035 -33.031 69.341 0.51 63.71  ? 110 ARG B C   1 
ATOM   3650 O O   A ARG B 1 84  ? -29.122 -33.273 68.757 0.49 61.68  ? 110 ARG B O   1 
ATOM   3651 O O   B ARG B 1 84  ? -29.123 -33.224 68.787 0.51 62.93  ? 110 ARG B O   1 
ATOM   3652 C CB  A ARG B 1 84  ? -28.300 -30.611 69.963 0.49 63.87  ? 110 ARG B CB  1 
ATOM   3653 C CB  B ARG B 1 84  ? -28.121 -30.625 70.090 0.51 63.85  ? 110 ARG B CB  1 
ATOM   3654 C CG  A ARG B 1 84  ? -28.325 -30.646 71.487 0.49 64.09  ? 110 ARG B CG  1 
ATOM   3655 C CG  B ARG B 1 84  ? -28.278 -30.965 71.567 0.51 63.97  ? 110 ARG B CG  1 
ATOM   3656 C CD  A ARG B 1 84  ? -29.584 -29.937 72.011 0.49 62.74  ? 110 ARG B CD  1 
ATOM   3657 C CD  B ARG B 1 84  ? -28.958 -29.833 72.329 0.51 62.91  ? 110 ARG B CD  1 
ATOM   3658 N NE  A ARG B 1 84  ? -29.580 -28.500 71.737 0.49 63.86  ? 110 ARG B NE  1 
ATOM   3659 N NE  B ARG B 1 84  ? -28.000 -28.873 72.877 0.51 60.03  ? 110 ARG B NE  1 
ATOM   3660 C CZ  A ARG B 1 84  ? -30.552 -27.838 71.106 0.49 64.84  ? 110 ARG B CZ  1 
ATOM   3661 C CZ  B ARG B 1 84  ? -28.181 -27.559 72.864 0.51 58.49  ? 110 ARG B CZ  1 
ATOM   3662 N NH1 A ARG B 1 84  ? -31.635 -28.473 70.664 0.49 63.63  ? 110 ARG B NH1 1 
ATOM   3663 N NH1 B ARG B 1 84  ? -27.265 -26.765 73.373 0.51 62.22  ? 110 ARG B NH1 1 
ATOM   3664 N NH2 A ARG B 1 84  ? -30.435 -26.529 70.916 0.49 60.34  ? 110 ARG B NH2 1 
ATOM   3665 N NH2 B ARG B 1 84  ? -29.281 -27.037 72.341 0.51 64.56  ? 110 ARG B NH2 1 
ATOM   3666 N N   . HIS B 1 85  ? -27.369 -33.974 69.997 1.00 60.29  ? 111 HIS B N   1 
ATOM   3667 C CA  . HIS B 1 85  ? -27.934 -35.306 70.185 1.00 61.89  ? 111 HIS B CA  1 
ATOM   3668 C C   . HIS B 1 85  ? -29.140 -35.224 71.121 1.00 61.61  ? 111 HIS B C   1 
ATOM   3669 O O   . HIS B 1 85  ? -29.030 -34.710 72.239 1.00 59.13  ? 111 HIS B O   1 
ATOM   3670 C CB  . HIS B 1 85  ? -26.881 -36.262 70.726 1.00 57.90  ? 111 HIS B CB  1 
ATOM   3671 C CG  . HIS B 1 85  ? -27.325 -37.690 70.744 1.00 64.48  ? 111 HIS B CG  1 
ATOM   3672 N ND1 . HIS B 1 85  ? -28.129 -38.207 71.741 1.00 68.25  ? 111 HIS B ND1 1 
ATOM   3673 C CD2 . HIS B 1 85  ? -27.056 -38.721 69.907 1.00 63.14  ? 111 HIS B CD2 1 
ATOM   3674 C CE1 . HIS B 1 85  ? -28.352 -39.489 71.506 1.00 64.89  ? 111 HIS B CE1 1 
ATOM   3675 N NE2 . HIS B 1 85  ? -27.710 -39.827 70.400 1.00 64.19  ? 111 HIS B NE2 1 
ATOM   3676 N N   . LYS B 1 86  ? -30.299 -35.703 70.666 1.00 63.42  ? 112 LYS B N   1 
ATOM   3677 C CA  . LYS B 1 86  ? -31.530 -35.436 71.406 1.00 61.10  ? 112 LYS B CA  1 
ATOM   3678 C C   . LYS B 1 86  ? -31.515 -36.097 72.778 1.00 64.44  ? 112 LYS B C   1 
ATOM   3679 O O   . LYS B 1 86  ? -31.910 -35.483 73.780 1.00 61.85  ? 112 LYS B O   1 
ATOM   3680 C CB  . LYS B 1 86  ? -32.732 -35.944 70.607 1.00 63.37  ? 112 LYS B CB  1 
ATOM   3681 C CG  . LYS B 1 86  ? -32.912 -35.299 69.245 1.00 68.98  ? 112 LYS B CG  1 
ATOM   3682 C CD  . LYS B 1 86  ? -34.390 -35.302 68.861 1.00 71.28  ? 112 LYS B CD  1 
ATOM   3683 C CE  . LYS B 1 86  ? -34.580 -34.927 67.405 1.00 69.57  ? 112 LYS B CE  1 
ATOM   3684 N NZ  . LYS B 1 86  ? -35.593 -35.802 66.734 1.00 73.69  ? 112 LYS B NZ  1 
ATOM   3685 N N   . ALA B 1 87  ? -31.027 -37.338 72.848 1.00 58.93  ? 113 ALA B N   1 
ATOM   3686 C CA  . ALA B 1 87  ? -31.017 -38.063 74.116 1.00 60.96  ? 113 ALA B CA  1 
ATOM   3687 C C   . ALA B 1 87  ? -30.018 -37.479 75.104 1.00 61.65  ? 113 ALA B C   1 
ATOM   3688 O O   . ALA B 1 87  ? -30.338 -37.332 76.285 1.00 58.09  ? 113 ALA B O   1 
ATOM   3689 C CB  . ALA B 1 87  ? -30.724 -39.549 73.887 1.00 62.16  ? 113 ALA B CB  1 
ATOM   3690 N N   . SER B 1 88  ? -28.801 -37.139 74.654 1.00 60.73  ? 114 SER B N   1 
ATOM   3691 C CA  . SER B 1 88  ? -27.755 -36.693 75.581 1.00 57.76  ? 114 SER B CA  1 
ATOM   3692 C C   . SER B 1 88  ? -27.589 -35.189 75.606 1.00 56.18  ? 114 SER B C   1 
ATOM   3693 O O   . SER B 1 88  ? -26.880 -34.681 76.484 1.00 51.43  ? 114 SER B O   1 
ATOM   3694 C CB  . SER B 1 88  ? -26.388 -37.292 75.210 1.00 56.40  ? 114 SER B CB  1 
ATOM   3695 O OG  . SER B 1 88  ? -25.968 -36.752 73.959 1.00 61.84  ? 114 SER B OG  1 
ATOM   3696 N N   . GLN B 1 89  ? -28.166 -34.472 74.632 1.00 58.77  ? 115 GLN B N   1 
ATOM   3697 C CA  . GLN B 1 89  ? -27.999 -33.024 74.488 1.00 61.93  ? 115 GLN B CA  1 
ATOM   3698 C C   . GLN B 1 89  ? -26.559 -32.598 74.183 1.00 61.10  ? 115 GLN B C   1 
ATOM   3699 O O   . GLN B 1 89  ? -26.228 -31.411 74.325 1.00 60.32  ? 115 GLN B O   1 
ATOM   3700 C CB  . GLN B 1 89  ? -28.518 -32.281 75.724 1.00 60.13  ? 115 GLN B CB  1 
ATOM   3701 C CG  . GLN B 1 89  ? -30.013 -32.493 75.928 1.00 60.51  ? 115 GLN B CG  1 
ATOM   3702 C CD  . GLN B 1 89  ? -30.826 -31.819 74.844 1.00 66.34  ? 115 GLN B CD  1 
ATOM   3703 O OE1 . GLN B 1 89  ? -30.939 -30.585 74.811 1.00 69.80  ? 115 GLN B OE1 1 
ATOM   3704 N NE2 . GLN B 1 89  ? -31.407 -32.620 73.952 1.00 67.16  ? 115 GLN B NE2 1 
ATOM   3705 N N   . LYS B 1 90  ? -25.666 -33.531 73.850 1.00 57.75  ? 116 LYS B N   1 
ATOM   3706 C CA  . LYS B 1 90  ? -24.315 -33.151 73.443 1.00 60.21  ? 116 LYS B CA  1 
ATOM   3707 C C   . LYS B 1 90  ? -24.288 -32.592 72.022 1.00 60.70  ? 116 LYS B C   1 
ATOM   3708 O O   . LYS B 1 90  ? -25.054 -33.014 71.137 1.00 58.18  ? 116 LYS B O   1 
ATOM   3709 C CB  . LYS B 1 90  ? -23.350 -34.325 73.631 1.00 58.29  ? 116 LYS B CB  1 
ATOM   3710 C CG  . LYS B 1 90  ? -22.977 -34.373 75.120 1.00 62.04  ? 116 LYS B CG  1 
ATOM   3711 C CD  . LYS B 1 90  ? -21.963 -35.421 75.528 1.00 70.28  ? 116 LYS B CD  1 
ATOM   3712 C CE  . LYS B 1 90  ? -21.885 -35.530 77.081 1.00 71.35  ? 116 LYS B CE  1 
ATOM   3713 N NZ  . LYS B 1 90  ? -21.695 -34.216 77.789 1.00 76.03  ? 116 LYS B NZ  1 
ATOM   3714 N N   . VAL B 1 91  ? -23.427 -31.592 71.824 1.00 58.55  ? 117 VAL B N   1 
ATOM   3715 C CA  . VAL B 1 91  ? -23.322 -30.856 70.570 1.00 58.27  ? 117 VAL B CA  1 
ATOM   3716 C C   . VAL B 1 91  ? -22.189 -31.415 69.715 1.00 61.87  ? 117 VAL B C   1 
ATOM   3717 O O   . VAL B 1 91  ? -21.077 -31.651 70.211 1.00 60.03  ? 117 VAL B O   1 
ATOM   3718 C CB  . VAL B 1 91  ? -23.099 -29.361 70.866 1.00 64.13  ? 117 VAL B CB  1 
ATOM   3719 C CG1 . VAL B 1 91  ? -22.712 -28.617 69.610 1.00 61.88  ? 117 VAL B CG1 1 
ATOM   3720 C CG2 . VAL B 1 91  ? -24.352 -28.764 71.494 1.00 65.46  ? 117 VAL B CG2 1 
ATOM   3721 N N   . TYR B 1 92  ? -22.445 -31.551 68.408 1.00 57.33  ? 118 TYR B N   1 
ATOM   3722 C CA  . TYR B 1 92  ? -21.457 -32.070 67.469 1.00 59.40  ? 118 TYR B CA  1 
ATOM   3723 C C   . TYR B 1 92  ? -21.569 -31.358 66.126 1.00 59.15  ? 118 TYR B C   1 
ATOM   3724 O O   . TYR B 1 92  ? -22.553 -30.682 65.820 1.00 58.72  ? 118 TYR B O   1 
ATOM   3725 C CB  . TYR B 1 92  ? -21.606 -33.579 67.222 1.00 56.32  ? 118 TYR B CB  1 
ATOM   3726 C CG  . TYR B 1 92  ? -21.616 -34.459 68.468 1.00 62.57  ? 118 TYR B CG  1 
ATOM   3727 C CD1 . TYR B 1 92  ? -20.431 -34.837 69.104 1.00 59.29  ? 118 TYR B CD1 1 
ATOM   3728 C CD2 . TYR B 1 92  ? -22.820 -34.945 68.979 1.00 59.96  ? 118 TYR B CD2 1 
ATOM   3729 C CE1 . TYR B 1 92  ? -20.461 -35.666 70.225 1.00 62.76  ? 118 TYR B CE1 1 
ATOM   3730 C CE2 . TYR B 1 92  ? -22.855 -35.760 70.071 1.00 59.44  ? 118 TYR B CE2 1 
ATOM   3731 C CZ  . TYR B 1 92  ? -21.688 -36.118 70.701 1.00 60.68  ? 118 TYR B CZ  1 
ATOM   3732 O OH  . TYR B 1 92  ? -21.771 -36.931 71.812 1.00 56.91  ? 118 TYR B OH  1 
ATOM   3733 N N   . ALA B 1 93  ? -20.545 -31.558 65.311 1.00 56.70  ? 119 ALA B N   1 
ATOM   3734 C CA  . ALA B 1 93  ? -20.571 -31.199 63.910 1.00 55.57  ? 119 ALA B CA  1 
ATOM   3735 C C   . ALA B 1 93  ? -20.875 -32.464 63.119 1.00 55.21  ? 119 ALA B C   1 
ATOM   3736 O O   . ALA B 1 93  ? -20.225 -33.495 63.326 1.00 58.31  ? 119 ALA B O   1 
ATOM   3737 C CB  . ALA B 1 93  ? -19.223 -30.604 63.503 1.00 56.97  ? 119 ALA B CB  1 
ATOM   3738 N N   . MET B 1 94  ? -21.895 -32.417 62.261 1.00 60.95  ? 120 MET B N   1 
ATOM   3739 C CA  . MET B 1 94  ? -22.317 -33.602 61.509 1.00 61.72  ? 120 MET B CA  1 
ATOM   3740 C C   . MET B 1 94  ? -22.196 -33.343 60.012 1.00 62.09  ? 120 MET B C   1 
ATOM   3741 O O   . MET B 1 94  ? -22.891 -32.479 59.470 1.00 61.87  ? 120 MET B O   1 
ATOM   3742 C CB  . MET B 1 94  ? -23.751 -34.010 61.858 1.00 59.96  ? 120 MET B CB  1 
ATOM   3743 C CG  . MET B 1 94  ? -24.197 -35.270 61.105 1.00 63.01  ? 120 MET B CG  1 
ATOM   3744 S SD  . MET B 1 94  ? -25.616 -36.091 61.880 1.00 74.76  ? 120 MET B SD  1 
ATOM   3745 C CE  . MET B 1 94  ? -27.015 -35.267 61.103 1.00 70.41  ? 120 MET B CE  1 
ATOM   3746 N N   . LYS B 1 95  ? -21.344 -34.111 59.343 1.00 60.18  ? 121 LYS B N   1 
ATOM   3747 C CA  . LYS B 1 95  ? -21.169 -34.001 57.904 1.00 62.41  ? 121 LYS B CA  1 
ATOM   3748 C C   . LYS B 1 95  ? -22.083 -34.992 57.178 1.00 64.03  ? 121 LYS B C   1 
ATOM   3749 O O   . LYS B 1 95  ? -22.137 -36.174 57.544 1.00 62.40  ? 121 LYS B O   1 
ATOM   3750 C CB  . LYS B 1 95  ? -19.712 -34.266 57.541 1.00 59.47  ? 121 LYS B CB  1 
ATOM   3751 C CG  . LYS B 1 95  ? -19.416 -34.210 56.050 1.00 62.42  ? 121 LYS B CG  1 
ATOM   3752 C CD  . LYS B 1 95  ? -17.922 -34.085 55.847 1.00 67.40  ? 121 LYS B CD  1 
ATOM   3753 C CE  . LYS B 1 95  ? -17.532 -34.197 54.395 1.00 69.44  ? 121 LYS B CE  1 
ATOM   3754 N NZ  . LYS B 1 95  ? -16.052 -33.969 54.244 1.00 70.91  ? 121 LYS B NZ  1 
ATOM   3755 N N   . LEU B 1 96  ? -22.805 -34.509 56.159 1.00 61.73  ? 122 LEU B N   1 
ATOM   3756 C CA  . LEU B 1 96  ? -23.699 -35.329 55.342 1.00 61.37  ? 122 LEU B CA  1 
ATOM   3757 C C   . LEU B 1 96  ? -23.180 -35.408 53.913 1.00 68.54  ? 122 LEU B C   1 
ATOM   3758 O O   . LEU B 1 96  ? -22.825 -34.385 53.317 1.00 69.37  ? 122 LEU B O   1 
ATOM   3759 C CB  . LEU B 1 96  ? -25.114 -34.764 55.299 1.00 64.21  ? 122 LEU B CB  1 
ATOM   3760 C CG  . LEU B 1 96  ? -26.026 -34.869 56.497 1.00 70.55  ? 122 LEU B CG  1 
ATOM   3761 C CD1 . LEU B 1 96  ? -25.732 -33.726 57.438 1.00 68.28  ? 122 LEU B CD1 1 
ATOM   3762 C CD2 . LEU B 1 96  ? -27.452 -34.801 55.983 1.00 73.98  ? 122 LEU B CD2 1 
ATOM   3763 N N   . LEU B 1 97  ? -23.172 -36.611 53.356 1.00 66.35  ? 123 LEU B N   1 
ATOM   3764 C CA  . LEU B 1 97  ? -22.817 -36.841 51.967 1.00 68.77  ? 123 LEU B CA  1 
ATOM   3765 C C   . LEU B 1 97  ? -24.033 -37.459 51.295 1.00 75.12  ? 123 LEU B C   1 
ATOM   3766 O O   . LEU B 1 97  ? -24.633 -38.397 51.837 1.00 72.71  ? 123 LEU B O   1 
ATOM   3767 C CB  . LEU B 1 97  ? -21.574 -37.729 51.863 1.00 65.08  ? 123 LEU B CB  1 
ATOM   3768 C CG  . LEU B 1 97  ? -20.361 -37.031 52.470 1.00 66.93  ? 123 LEU B CG  1 
ATOM   3769 C CD1 . LEU B 1 97  ? -19.075 -37.860 52.455 1.00 63.62  ? 123 LEU B CD1 1 
ATOM   3770 C CD2 . LEU B 1 97  ? -20.138 -35.729 51.743 1.00 68.85  ? 123 LEU B CD2 1 
ATOM   3771 N N   . SER B 1 98  ? -24.452 -36.881 50.167 1.00 71.54  ? 124 SER B N   1 
ATOM   3772 C CA  . SER B 1 98  ? -25.652 -37.372 49.494 1.00 76.61  ? 124 SER B CA  1 
ATOM   3773 C C   . SER B 1 98  ? -25.286 -38.587 48.659 1.00 75.09  ? 124 SER B C   1 
ATOM   3774 O O   . SER B 1 98  ? -24.389 -38.521 47.808 1.00 74.57  ? 124 SER B O   1 
ATOM   3775 C CB  . SER B 1 98  ? -26.285 -36.298 48.605 1.00 76.89  ? 124 SER B CB  1 
ATOM   3776 O OG  . SER B 1 98  ? -27.301 -36.845 47.770 1.00 73.95  ? 124 SER B OG  1 
ATOM   3777 N N   . LYS B 1 99  ? -25.977 -39.699 48.905 1.00 73.39  ? 125 LYS B N   1 
ATOM   3778 C CA  . LYS B 1 99  ? -25.709 -40.867 48.085 1.00 80.57  ? 125 LYS B CA  1 
ATOM   3779 C C   . LYS B 1 99  ? -26.184 -40.619 46.659 1.00 80.85  ? 125 LYS B C   1 
ATOM   3780 O O   . LYS B 1 99  ? -25.427 -40.853 45.709 1.00 75.58  ? 125 LYS B O   1 
ATOM   3781 C CB  . LYS B 1 99  ? -26.364 -42.119 48.686 1.00 75.94  ? 125 LYS B CB  1 
ATOM   3782 C CG  . LYS B 1 99  ? -25.622 -42.713 49.903 1.00 70.85  ? 125 LYS B CG  1 
ATOM   3783 C CD  . LYS B 1 99  ? -26.413 -43.845 50.540 1.00 69.06  ? 125 LYS B CD  1 
ATOM   3784 C CE  . LYS B 1 99  ? -25.631 -44.518 51.673 1.00 67.91  ? 125 LYS B CE  1 
ATOM   3785 N NZ  . LYS B 1 99  ? -26.476 -45.527 52.367 1.00 61.22  ? 125 LYS B NZ  1 
ATOM   3786 N N   . PHE B 1 100 ? -27.371 -40.010 46.493 1.00 82.46  ? 126 PHE B N   1 
ATOM   3787 C CA  . PHE B 1 100 ? -27.873 -39.786 45.137 1.00 87.39  ? 126 PHE B CA  1 
ATOM   3788 C C   . PHE B 1 100 ? -26.861 -39.033 44.284 1.00 82.05  ? 126 PHE B C   1 
ATOM   3789 O O   . PHE B 1 100 ? -26.659 -39.379 43.120 1.00 87.18  ? 126 PHE B O   1 
ATOM   3790 C CB  . PHE B 1 100 ? -29.210 -39.042 45.124 1.00 90.10  ? 126 PHE B CB  1 
ATOM   3791 C CG  . PHE B 1 100 ? -29.837 -38.988 43.747 1.00 97.17  ? 126 PHE B CG  1 
ATOM   3792 C CD1 . PHE B 1 100 ? -30.512 -40.090 43.226 1.00 100.02 ? 126 PHE B CD1 1 
ATOM   3793 C CD2 . PHE B 1 100 ? -29.705 -37.860 42.956 1.00 94.96  ? 126 PHE B CD2 1 
ATOM   3794 C CE1 . PHE B 1 100 ? -31.058 -40.058 41.956 1.00 99.01  ? 126 PHE B CE1 1 
ATOM   3795 C CE2 . PHE B 1 100 ? -30.252 -37.823 41.684 1.00 99.00  ? 126 PHE B CE2 1 
ATOM   3796 C CZ  . PHE B 1 100 ? -30.935 -38.924 41.188 1.00 99.91  ? 126 PHE B CZ  1 
ATOM   3797 N N   . GLU B 1 101 ? -26.197 -38.022 44.841 1.00 85.10  ? 127 GLU B N   1 
ATOM   3798 C CA  . GLU B 1 101 ? -25.259 -37.270 44.024 1.00 87.38  ? 127 GLU B CA  1 
ATOM   3799 C C   . GLU B 1 101 ? -23.834 -37.803 44.065 1.00 84.20  ? 127 GLU B C   1 
ATOM   3800 O O   . GLU B 1 101 ? -23.012 -37.386 43.248 1.00 86.66  ? 127 GLU B O   1 
ATOM   3801 C CB  . GLU B 1 101 ? -25.314 -35.779 44.359 1.00 90.02  ? 127 GLU B CB  1 
ATOM   3802 C CG  . GLU B 1 101 ? -24.954 -35.070 43.056 1.00 100.11 ? 127 GLU B CG  1 
ATOM   3803 C CD  . GLU B 1 101 ? -25.790 -33.853 42.741 1.00 101.36 ? 127 GLU B CD  1 
ATOM   3804 O OE1 . GLU B 1 101 ? -25.617 -33.310 41.622 1.00 107.22 ? 127 GLU B OE1 1 
ATOM   3805 O OE2 . GLU B 1 101 ? -26.626 -33.456 43.581 1.00 104.89 ? 127 GLU B OE2 1 
ATOM   3806 N N   . MET B 1 102 ? -23.493 -38.689 44.989 1.00 83.40  ? 128 MET B N   1 
ATOM   3807 C CA  . MET B 1 102 ? -22.215 -39.363 44.827 1.00 85.23  ? 128 MET B CA  1 
ATOM   3808 C C   . MET B 1 102 ? -22.322 -40.416 43.728 1.00 83.71  ? 128 MET B C   1 
ATOM   3809 O O   . MET B 1 102 ? -21.339 -40.686 43.026 1.00 79.37  ? 128 MET B O   1 
ATOM   3810 C CB  . MET B 1 102 ? -21.784 -39.983 46.149 1.00 83.25  ? 128 MET B CB  1 
ATOM   3811 C CG  . MET B 1 102 ? -21.215 -38.992 47.153 1.00 78.57  ? 128 MET B CG  1 
ATOM   3812 S SD  . MET B 1 102 ? -20.646 -39.855 48.636 1.00 72.94  ? 128 MET B SD  1 
ATOM   3813 C CE  . MET B 1 102 ? -22.229 -40.375 49.261 1.00 73.53  ? 128 MET B CE  1 
ATOM   3814 N N   . ILE B 1 103 ? -23.550 -40.903 43.494 1.00 83.47  ? 129 ILE B N   1 
ATOM   3815 C CA  . ILE B 1 103 ? -23.868 -41.960 42.521 1.00 84.84  ? 129 ILE B CA  1 
ATOM   3816 C C   . ILE B 1 103 ? -24.120 -41.348 41.152 1.00 90.02  ? 129 ILE B C   1 
ATOM   3817 O O   . ILE B 1 103 ? -23.577 -41.796 40.134 1.00 86.80  ? 129 ILE B O   1 
ATOM   3818 C CB  . ILE B 1 103 ? -25.160 -42.768 42.898 1.00 88.92  ? 129 ILE B CB  1 
ATOM   3819 C CG1 . ILE B 1 103 ? -25.257 -43.370 44.293 1.00 85.50  ? 129 ILE B CG1 1 
ATOM   3820 C CG2 . ILE B 1 103 ? -25.311 -43.926 41.985 1.00 86.32  ? 129 ILE B CG2 1 
ATOM   3821 C CD1 . ILE B 1 103 ? -24.737 -44.854 44.392 1.00 80.18  ? 129 ILE B CD1 1 
ATOM   3822 N N   . LYS B 1 104 ? -24.896 -40.250 41.153 1.00 89.22  ? 130 LYS B N   1 
ATOM   3823 C CA  . LYS B 1 104 ? -25.269 -39.546 39.936 1.00 90.94  ? 130 LYS B CA  1 
ATOM   3824 C C   . LYS B 1 104 ? -24.081 -38.904 39.240 1.00 89.66  ? 130 LYS B C   1 
ATOM   3825 O O   . LYS B 1 104 ? -24.210 -38.525 38.076 1.00 94.86  ? 130 LYS B O   1 
ATOM   3826 C CB  . LYS B 1 104 ? -26.355 -38.513 40.271 1.00 85.62  ? 130 LYS B CB  1 
ATOM   3827 N N   . ARG B 1 105 ? -22.949 -38.734 39.922 1.00 86.19  ? 131 ARG B N   1 
ATOM   3828 C CA  . ARG B 1 105 ? -21.724 -38.252 39.290 1.00 91.42  ? 131 ARG B CA  1 
ATOM   3829 C C   . ARG B 1 105 ? -20.583 -39.193 39.598 1.00 89.60  ? 131 ARG B C   1 
ATOM   3830 O O   . ARG B 1 105 ? -19.404 -38.831 39.425 1.00 87.00  ? 131 ARG B O   1 
ATOM   3831 C CB  . ARG B 1 105 ? -21.365 -36.838 39.767 1.00 90.87  ? 131 ARG B CB  1 
ATOM   3832 C CG  . ARG B 1 105 ? -22.526 -35.940 40.191 1.00 90.67  ? 131 ARG B CG  1 
ATOM   3833 C CD  . ARG B 1 105 ? -22.066 -34.482 40.331 1.00 97.67  ? 131 ARG B CD  1 
ATOM   3834 N NE  . ARG B 1 105 ? -22.960 -33.690 41.177 1.00 106.67 ? 131 ARG B NE  1 
ATOM   3835 C CZ  . ARG B 1 105 ? -22.578 -32.655 41.924 1.00 104.66 ? 131 ARG B CZ  1 
ATOM   3836 N NH1 . ARG B 1 105 ? -21.302 -32.293 41.943 1.00 104.02 ? 131 ARG B NH1 1 
ATOM   3837 N NH2 . ARG B 1 105 ? -23.459 -31.994 42.670 1.00 109.45 ? 131 ARG B NH2 1 
ATOM   3838 N N   . SER B 1 106 ? -20.936 -40.372 40.116 1.00 92.23  ? 132 SER B N   1 
ATOM   3839 C CA  . SER B 1 106 ? -20.069 -41.552 40.203 1.00 92.73  ? 132 SER B CA  1 
ATOM   3840 C C   . SER B 1 106 ? -18.657 -41.149 40.622 1.00 93.89  ? 132 SER B C   1 
ATOM   3841 O O   . SER B 1 106 ? -17.665 -41.372 39.921 1.00 94.69  ? 132 SER B O   1 
ATOM   3842 C CB  . SER B 1 106 ? -20.110 -42.419 38.955 1.00 97.25  ? 132 SER B CB  1 
ATOM   3843 O OG  . SER B 1 106 ? -19.981 -41.689 37.768 1.00 102.64 ? 132 SER B OG  1 
ATOM   3844 N N   . ASP B 1 107 ? -18.628 -40.435 41.761 1.00 95.07  ? 133 ASP B N   1 
ATOM   3845 C CA  . ASP B 1 107 ? -17.511 -40.244 42.690 1.00 95.14  ? 133 ASP B CA  1 
ATOM   3846 C C   . ASP B 1 107 ? -18.117 -40.783 43.979 1.00 94.76  ? 133 ASP B C   1 
ATOM   3847 O O   . ASP B 1 107 ? -18.944 -40.114 44.614 1.00 91.50  ? 133 ASP B O   1 
ATOM   3848 C CB  . ASP B 1 107 ? -17.099 -38.780 42.840 1.00 89.87  ? 133 ASP B CB  1 
ATOM   3849 C CG  . ASP B 1 107 ? -15.654 -38.629 43.307 1.00 98.75  ? 133 ASP B CG  1 
ATOM   3850 O OD1 . ASP B 1 107 ? -15.153 -37.480 43.407 1.00 101.62 ? 133 ASP B OD1 1 
ATOM   3851 O OD2 . ASP B 1 107 ? -15.021 -39.674 43.581 1.00 98.67  ? 133 ASP B OD2 1 
ATOM   3852 N N   . SER B 1 108 ? -17.718 -42.001 44.337 1.00 91.26  ? 134 SER B N   1 
ATOM   3853 C CA  . SER B 1 108 ? -18.318 -42.700 45.464 1.00 85.36  ? 134 SER B CA  1 
ATOM   3854 C C   . SER B 1 108 ? -17.271 -43.420 46.304 1.00 79.03  ? 134 SER B C   1 
ATOM   3855 O O   . SER B 1 108 ? -17.607 -44.384 47.000 1.00 78.71  ? 134 SER B O   1 
ATOM   3856 C CB  . SER B 1 108 ? -19.359 -43.717 44.977 1.00 86.58  ? 134 SER B CB  1 
ATOM   3857 O OG  . SER B 1 108 ? -18.786 -44.617 44.040 1.00 92.28  ? 134 SER B OG  1 
ATOM   3858 N N   . ALA B 1 109 ? -16.018 -42.989 46.249 1.00 81.07  ? 135 ALA B N   1 
ATOM   3859 C CA  . ALA B 1 109 ? -14.945 -43.623 46.991 1.00 75.23  ? 135 ALA B CA  1 
ATOM   3860 C C   . ALA B 1 109 ? -14.025 -42.627 47.685 1.00 76.96  ? 135 ALA B C   1 
ATOM   3861 O O   . ALA B 1 109 ? -13.024 -43.052 48.279 1.00 80.19  ? 135 ALA B O   1 
ATOM   3862 C CB  . ALA B 1 109 ? -14.121 -44.535 46.071 1.00 78.89  ? 135 ALA B CB  1 
ATOM   3863 N N   . PHE B 1 110 ? -14.313 -41.316 47.599 1.00 75.90  ? 136 PHE B N   1 
ATOM   3864 C CA  . PHE B 1 110 ? -13.397 -40.295 48.117 1.00 79.14  ? 136 PHE B CA  1 
ATOM   3865 C C   . PHE B 1 110 ? -13.361 -40.262 49.636 1.00 76.92  ? 136 PHE B C   1 
ATOM   3866 O O   . PHE B 1 110 ? -12.335 -39.901 50.221 1.00 81.78  ? 136 PHE B O   1 
ATOM   3867 C CB  . PHE B 1 110 ? -13.793 -38.911 47.597 1.00 75.66  ? 136 PHE B CB  1 
ATOM   3868 C CG  . PHE B 1 110 ? -15.203 -38.491 47.965 1.00 78.93  ? 136 PHE B CG  1 
ATOM   3869 C CD1 . PHE B 1 110 ? -15.459 -37.820 49.161 1.00 78.61  ? 136 PHE B CD1 1 
ATOM   3870 C CD2 . PHE B 1 110 ? -16.267 -38.732 47.102 1.00 81.88  ? 136 PHE B CD2 1 
ATOM   3871 C CE1 . PHE B 1 110 ? -16.764 -37.428 49.502 1.00 78.23  ? 136 PHE B CE1 1 
ATOM   3872 C CE2 . PHE B 1 110 ? -17.574 -38.339 47.434 1.00 84.12  ? 136 PHE B CE2 1 
ATOM   3873 C CZ  . PHE B 1 110 ? -17.821 -37.689 48.634 1.00 76.35  ? 136 PHE B CZ  1 
ATOM   3874 N N   . PHE B 1 111 ? -14.469 -40.630 50.282 1.00 78.33  ? 137 PHE B N   1 
ATOM   3875 C CA  . PHE B 1 111 ? -14.694 -40.429 51.708 1.00 77.01  ? 137 PHE B CA  1 
ATOM   3876 C C   . PHE B 1 111 ? -14.029 -41.463 52.608 1.00 71.84  ? 137 PHE B C   1 
ATOM   3877 O O   . PHE B 1 111 ? -14.026 -41.260 53.826 1.00 69.34  ? 137 PHE B O   1 
ATOM   3878 C CB  . PHE B 1 111 ? -16.201 -40.425 51.991 1.00 75.05  ? 137 PHE B CB  1 
ATOM   3879 C CG  . PHE B 1 111 ? -16.926 -41.604 51.409 1.00 75.56  ? 137 PHE B CG  1 
ATOM   3880 C CD1 . PHE B 1 111 ? -16.894 -42.848 52.046 1.00 72.99  ? 137 PHE B CD1 1 
ATOM   3881 C CD2 . PHE B 1 111 ? -17.635 -41.476 50.219 1.00 73.80  ? 137 PHE B CD2 1 
ATOM   3882 C CE1 . PHE B 1 111 ? -17.565 -43.939 51.501 1.00 73.68  ? 137 PHE B CE1 1 
ATOM   3883 C CE2 . PHE B 1 111 ? -18.307 -42.553 49.674 1.00 72.89  ? 137 PHE B CE2 1 
ATOM   3884 C CZ  . PHE B 1 111 ? -18.271 -43.789 50.305 1.00 72.94  ? 137 PHE B CZ  1 
ATOM   3885 N N   . TRP B 1 112 ? -13.514 -42.573 52.061 1.00 72.60  ? 138 TRP B N   1 
ATOM   3886 C CA  . TRP B 1 112 ? -13.046 -43.665 52.917 1.00 70.48  ? 138 TRP B CA  1 
ATOM   3887 C C   . TRP B 1 112 ? -11.887 -43.231 53.793 1.00 74.31  ? 138 TRP B C   1 
ATOM   3888 O O   . TRP B 1 112 ? -11.793 -43.645 54.953 1.00 71.17  ? 138 TRP B O   1 
ATOM   3889 C CB  . TRP B 1 112 ? -12.656 -44.891 52.085 1.00 69.68  ? 138 TRP B CB  1 
ATOM   3890 C CG  . TRP B 1 112 ? -13.853 -45.651 51.592 1.00 73.62  ? 138 TRP B CG  1 
ATOM   3891 C CD1 . TRP B 1 112 ? -14.288 -45.752 50.302 1.00 73.38  ? 138 TRP B CD1 1 
ATOM   3892 C CD2 . TRP B 1 112 ? -14.797 -46.383 52.391 1.00 75.98  ? 138 TRP B CD2 1 
ATOM   3893 N NE1 . TRP B 1 112 ? -15.442 -46.508 50.246 1.00 77.43  ? 138 TRP B NE1 1 
ATOM   3894 C CE2 . TRP B 1 112 ? -15.772 -46.909 51.511 1.00 72.60  ? 138 TRP B CE2 1 
ATOM   3895 C CE3 . TRP B 1 112 ? -14.913 -46.645 53.765 1.00 71.38  ? 138 TRP B CE3 1 
ATOM   3896 C CZ2 . TRP B 1 112 ? -16.838 -47.682 51.957 1.00 76.05  ? 138 TRP B CZ2 1 
ATOM   3897 C CZ3 . TRP B 1 112 ? -15.966 -47.415 54.203 1.00 67.36  ? 138 TRP B CZ3 1 
ATOM   3898 C CH2 . TRP B 1 112 ? -16.921 -47.921 53.305 1.00 69.15  ? 138 TRP B CH2 1 
ATOM   3899 N N   . GLU B 1 113 ? -11.001 -42.388 53.267 1.00 72.90  ? 139 GLU B N   1 
ATOM   3900 C CA  . GLU B 1 113 ? -9.837  -41.993 54.050 1.00 73.37  ? 139 GLU B CA  1 
ATOM   3901 C C   . GLU B 1 113 ? -10.192 -40.966 55.116 1.00 71.39  ? 139 GLU B C   1 
ATOM   3902 O O   . GLU B 1 113 ? -9.611  -40.989 56.202 1.00 68.90  ? 139 GLU B O   1 
ATOM   3903 C CB  . GLU B 1 113 ? -8.722  -41.469 53.134 1.00 77.99  ? 139 GLU B CB  1 
ATOM   3904 C CG  . GLU B 1 113 ? -7.633  -42.523 52.847 1.00 84.84  ? 139 GLU B CG  1 
ATOM   3905 C CD  . GLU B 1 113 ? -7.414  -43.509 54.015 1.00 94.31  ? 139 GLU B CD  1 
ATOM   3906 O OE1 . GLU B 1 113 ? -7.611  -44.737 53.823 1.00 97.67  ? 139 GLU B OE1 1 
ATOM   3907 O OE2 . GLU B 1 113 ? -7.042  -43.057 55.128 1.00 92.37  ? 139 GLU B OE2 1 
ATOM   3908 N N   . GLU B 1 114 ? -11.132 -40.065 54.836 1.00 69.72  ? 140 GLU B N   1 
ATOM   3909 C CA  . GLU B 1 114 ? -11.611 -39.177 55.881 1.00 71.25  ? 140 GLU B CA  1 
ATOM   3910 C C   . GLU B 1 114 ? -12.086 -39.999 57.078 1.00 70.85  ? 140 GLU B C   1 
ATOM   3911 O O   . GLU B 1 114 ? -11.598 -39.824 58.205 1.00 65.23  ? 140 GLU B O   1 
ATOM   3912 C CB  . GLU B 1 114 ? -12.738 -38.291 55.341 1.00 67.62  ? 140 GLU B CB  1 
ATOM   3913 C CG  . GLU B 1 114 ? -12.802 -36.905 55.974 1.00 73.47  ? 140 GLU B CG  1 
ATOM   3914 C CD  . GLU B 1 114 ? -14.121 -36.173 55.719 1.00 80.30  ? 140 GLU B CD  1 
ATOM   3915 O OE1 . GLU B 1 114 ? -14.906 -36.610 54.841 1.00 77.96  ? 140 GLU B OE1 1 
ATOM   3916 O OE2 . GLU B 1 114 ? -14.379 -35.161 56.418 1.00 85.17  ? 140 GLU B OE2 1 
ATOM   3917 N N   . ARG B 1 115 ? -12.945 -40.989 56.817 1.00 68.83  ? 141 ARG B N   1 
ATOM   3918 C CA  . ARG B 1 115 ? -13.523 -41.790 57.888 1.00 66.99  ? 141 ARG B CA  1 
ATOM   3919 C C   . ARG B 1 115 ? -12.446 -42.436 58.744 1.00 68.57  ? 141 ARG B C   1 
ATOM   3920 O O   . ARG B 1 115 ? -12.503 -42.375 59.978 1.00 64.37  ? 141 ARG B O   1 
ATOM   3921 C CB  . ARG B 1 115 ? -14.437 -42.858 57.299 1.00 62.54  ? 141 ARG B CB  1 
ATOM   3922 C CG  . ARG B 1 115 ? -14.813 -43.948 58.274 1.00 65.02  ? 141 ARG B CG  1 
ATOM   3923 C CD  . ARG B 1 115 ? -15.424 -45.070 57.491 1.00 64.70  ? 141 ARG B CD  1 
ATOM   3924 N NE  . ARG B 1 115 ? -15.967 -46.138 58.306 1.00 57.11  ? 141 ARG B NE  1 
ATOM   3925 C CZ  . ARG B 1 115 ? -15.280 -47.193 58.726 1.00 61.11  ? 141 ARG B CZ  1 
ATOM   3926 N NH1 . ARG B 1 115 ? -13.986 -47.313 58.421 1.00 60.31  ? 141 ARG B NH1 1 
ATOM   3927 N NH2 . ARG B 1 115 ? -15.898 -48.126 59.456 1.00 54.28  ? 141 ARG B NH2 1 
ATOM   3928 N N   . ASP B 1 116 ? -11.439 -43.038 58.111 1.00 65.09  ? 142 ASP B N   1 
ATOM   3929 C CA  . ASP B 1 116 ? -10.447 -43.768 58.901 1.00 73.94  ? 142 ASP B CA  1 
ATOM   3930 C C   . ASP B 1 116 ? -9.493  -42.829 59.628 1.00 67.00  ? 142 ASP B C   1 
ATOM   3931 O O   . ASP B 1 116 ? -9.057  -43.142 60.734 1.00 67.27  ? 142 ASP B O   1 
ATOM   3932 C CB  . ASP B 1 116 ? -9.681  -44.762 58.021 1.00 80.29  ? 142 ASP B CB  1 
ATOM   3933 C CG  . ASP B 1 116 ? -10.523 -46.008 57.689 1.00 89.64  ? 142 ASP B CG  1 
ATOM   3934 O OD1 . ASP B 1 116 ? -11.627 -45.849 57.094 1.00 83.37  ? 142 ASP B OD1 1 
ATOM   3935 O OD2 . ASP B 1 116 ? -10.106 -47.136 58.062 1.00 93.68  ? 142 ASP B OD2 1 
ATOM   3936 N N   . ILE B 1 117 ? -9.168  -41.687 59.024 1.00 65.97  ? 143 ILE B N   1 
ATOM   3937 C CA  . ILE B 1 117 ? -8.330  -40.683 59.676 1.00 65.78  ? 143 ILE B CA  1 
ATOM   3938 C C   . ILE B 1 117 ? -9.007  -40.177 60.952 1.00 65.48  ? 143 ILE B C   1 
ATOM   3939 O O   . ILE B 1 117 ? -8.462  -40.269 62.055 1.00 59.88  ? 143 ILE B O   1 
ATOM   3940 C CB  . ILE B 1 117 ? -8.068  -39.517 58.703 1.00 63.81  ? 143 ILE B CB  1 
ATOM   3941 C CG1 . ILE B 1 117 ? -7.164  -39.935 57.551 1.00 76.66  ? 143 ILE B CG1 1 
ATOM   3942 C CG2 . ILE B 1 117 ? -7.469  -38.316 59.411 1.00 69.26  ? 143 ILE B CG2 1 
ATOM   3943 C CD1 . ILE B 1 117 ? -7.181  -38.916 56.399 1.00 75.51  ? 143 ILE B CD1 1 
ATOM   3944 N N   . MET B 1 118 ? -10.227 -39.667 60.816 1.00 57.55  ? 144 MET B N   1 
ATOM   3945 C CA  . MET B 1 118 ? -10.903 -39.065 61.952 1.00 62.75  ? 144 MET B CA  1 
ATOM   3946 C C   . MET B 1 118 ? -11.283 -40.097 63.011 1.00 61.59  ? 144 MET B C   1 
ATOM   3947 O O   . MET B 1 118 ? -11.335 -39.770 64.201 1.00 57.54  ? 144 MET B O   1 
ATOM   3948 C CB  . MET B 1 118 ? -12.134 -38.302 61.463 1.00 58.71  ? 144 MET B CB  1 
ATOM   3949 C CG  . MET B 1 118 ? -11.817 -37.187 60.464 1.00 58.17  ? 144 MET B CG  1 
ATOM   3950 S SD  . MET B 1 118 ? -13.200 -36.029 60.393 1.00 69.52  ? 144 MET B SD  1 
ATOM   3951 C CE  . MET B 1 118 ? -14.494 -37.043 59.652 1.00 66.46  ? 144 MET B CE  1 
ATOM   3952 N N   . ALA B 1 119 ? -11.547 -41.340 62.615 1.00 62.96  ? 145 ALA B N   1 
ATOM   3953 C CA  . ALA B 1 119 ? -11.909 -42.339 63.614 1.00 65.96  ? 145 ALA B CA  1 
ATOM   3954 C C   . ALA B 1 119 ? -10.697 -42.778 64.423 1.00 63.81  ? 145 ALA B C   1 
ATOM   3955 O O   . ALA B 1 119 ? -10.797 -42.955 65.639 1.00 61.31  ? 145 ALA B O   1 
ATOM   3956 C CB  . ALA B 1 119 ? -12.558 -43.558 62.953 1.00 58.75  ? 145 ALA B CB  1 
ATOM   3957 N N   . PHE B 1 120 ? -9.544  -42.957 63.766 1.00 64.98  ? 146 PHE B N   1 
ATOM   3958 C CA  . PHE B 1 120 ? -8.442  -43.734 64.331 1.00 68.46  ? 146 PHE B CA  1 
ATOM   3959 C C   . PHE B 1 120 ? -7.119  -42.994 64.472 1.00 68.19  ? 146 PHE B C   1 
ATOM   3960 O O   . PHE B 1 120 ? -6.196  -43.550 65.072 1.00 71.61  ? 146 PHE B O   1 
ATOM   3961 C CB  . PHE B 1 120 ? -8.183  -44.996 63.474 1.00 71.35  ? 146 PHE B CB  1 
ATOM   3962 C CG  . PHE B 1 120 ? -9.399  -45.854 63.280 1.00 70.81  ? 146 PHE B CG  1 
ATOM   3963 C CD1 . PHE B 1 120 ? -10.101 -46.343 64.377 1.00 69.04  ? 146 PHE B CD1 1 
ATOM   3964 C CD2 . PHE B 1 120 ? -9.870  -46.134 62.014 1.00 70.93  ? 146 PHE B CD2 1 
ATOM   3965 C CE1 . PHE B 1 120 ? -11.242 -47.112 64.206 1.00 70.12  ? 146 PHE B CE1 1 
ATOM   3966 C CE2 . PHE B 1 120 ? -11.007 -46.902 61.837 1.00 72.86  ? 146 PHE B CE2 1 
ATOM   3967 C CZ  . PHE B 1 120 ? -11.698 -47.386 62.951 1.00 69.73  ? 146 PHE B CZ  1 
ATOM   3968 N N   . ALA B 1 121 ? -6.979  -41.785 63.930 1.00 68.24  ? 147 ALA B N   1 
ATOM   3969 C CA  . ALA B 1 121 ? -5.694  -41.096 64.038 1.00 76.15  ? 147 ALA B CA  1 
ATOM   3970 C C   . ALA B 1 121 ? -5.293  -40.874 65.495 1.00 70.79  ? 147 ALA B C   1 
ATOM   3971 O O   . ALA B 1 121 ? -4.120  -41.035 65.852 1.00 73.86  ? 147 ALA B O   1 
ATOM   3972 C CB  . ALA B 1 121 ? -5.735  -39.768 63.281 1.00 70.04  ? 147 ALA B CB  1 
ATOM   3973 N N   . ASN B 1 122 ? -6.250  -40.517 66.349 1.00 66.15  ? 148 ASN B N   1 
ATOM   3974 C CA  . ASN B 1 122 ? -5.983  -40.268 67.760 1.00 70.90  ? 148 ASN B CA  1 
ATOM   3975 C C   . ASN B 1 122 ? -4.778  -39.330 67.914 1.00 70.15  ? 148 ASN B C   1 
ATOM   3976 O O   . ASN B 1 122 ? -3.764  -39.643 68.534 1.00 72.68  ? 148 ASN B O   1 
ATOM   3977 C CB  . ASN B 1 122 ? -5.789  -41.594 68.495 1.00 78.36  ? 148 ASN B CB  1 
ATOM   3978 C CG  . ASN B 1 122 ? -5.833  -41.442 69.994 1.00 82.81  ? 148 ASN B CG  1 
ATOM   3979 O OD1 . ASN B 1 122 ? -6.510  -40.556 70.519 1.00 85.57  ? 148 ASN B OD1 1 
ATOM   3980 N ND2 . ASN B 1 122 ? -5.111  -42.308 70.696 1.00 85.78  ? 148 ASN B ND2 1 
ATOM   3981 N N   . SER B 1 123 ? -4.910  -38.164 67.305 1.00 66.32  ? 149 SER B N   1 
ATOM   3982 C CA  . SER B 1 123 ? -3.890  -37.143 67.257 1.00 63.94  ? 149 SER B CA  1 
ATOM   3983 C C   . SER B 1 123 ? -4.539  -35.809 67.587 1.00 66.98  ? 149 SER B C   1 
ATOM   3984 O O   . SER B 1 123 ? -5.704  -35.571 67.227 1.00 64.21  ? 149 SER B O   1 
ATOM   3985 C CB  . SER B 1 123 ? -3.252  -37.084 65.858 1.00 66.02  ? 149 SER B CB  1 
ATOM   3986 O OG  . SER B 1 123 ? -2.837  -35.772 65.512 1.00 62.38  ? 149 SER B OG  1 
ATOM   3987 N N   . PRO B 1 124 ? -3.817  -34.921 68.273 1.00 59.34  ? 150 PRO B N   1 
ATOM   3988 C CA  . PRO B 1 124 ? -4.397  -33.611 68.600 1.00 60.50  ? 150 PRO B CA  1 
ATOM   3989 C C   . PRO B 1 124 ? -4.583  -32.706 67.374 1.00 59.36  ? 150 PRO B C   1 
ATOM   3990 O O   . PRO B 1 124 ? -5.202  -31.634 67.503 1.00 54.82  ? 150 PRO B O   1 
ATOM   3991 C CB  . PRO B 1 124 ? -3.384  -33.017 69.588 1.00 57.00  ? 150 PRO B CB  1 
ATOM   3992 C CG  . PRO B 1 124 ? -2.061  -33.653 69.169 1.00 60.46  ? 150 PRO B CG  1 
ATOM   3993 C CD  . PRO B 1 124 ? -2.405  -35.041 68.678 1.00 57.89  ? 150 PRO B CD  1 
ATOM   3994 N N   . TRP B 1 125 ? -4.070  -33.105 66.204 1.00 57.22  ? 151 TRP B N   1 
ATOM   3995 C CA  . TRP B 1 125 ? -4.118  -32.308 64.980 1.00 57.49  ? 151 TRP B CA  1 
ATOM   3996 C C   . TRP B 1 125 ? -5.285  -32.670 64.064 1.00 57.31  ? 151 TRP B C   1 
ATOM   3997 O O   . TRP B 1 125 ? -5.486  -31.997 63.054 1.00 59.04  ? 151 TRP B O   1 
ATOM   3998 C CB  . TRP B 1 125 ? -2.787  -32.436 64.211 1.00 54.53  ? 151 TRP B CB  1 
ATOM   3999 C CG  . TRP B 1 125 ? -1.574  -31.942 65.001 1.00 57.97  ? 151 TRP B CG  1 
ATOM   4000 C CD1 . TRP B 1 125 ? -0.501  -32.691 65.434 1.00 56.87  ? 151 TRP B CD1 1 
ATOM   4001 C CD2 . TRP B 1 125 ? -1.348  -30.611 65.478 1.00 56.28  ? 151 TRP B CD2 1 
ATOM   4002 N NE1 . TRP B 1 125 ? 0.377   -31.901 66.140 1.00 55.56  ? 151 TRP B NE1 1 
ATOM   4003 C CE2 . TRP B 1 125 ? -0.121  -30.625 66.194 1.00 61.33  ? 151 TRP B CE2 1 
ATOM   4004 C CE3 . TRP B 1 125 ? -2.072  -29.413 65.392 1.00 51.64  ? 151 TRP B CE3 1 
ATOM   4005 C CZ2 . TRP B 1 125 ? 0.401   -29.481 66.806 1.00 57.84  ? 151 TRP B CZ2 1 
ATOM   4006 C CZ3 . TRP B 1 125 ? -1.554  -28.278 65.990 1.00 60.02  ? 151 TRP B CZ3 1 
ATOM   4007 C CH2 . TRP B 1 125 ? -0.322  -28.315 66.685 1.00 58.62  ? 151 TRP B CH2 1 
ATOM   4008 N N   . VAL B 1 126 ? -6.066  -33.691 64.397 1.00 60.02  ? 152 VAL B N   1 
ATOM   4009 C CA  . VAL B 1 126 ? -7.118  -34.217 63.531 1.00 60.50  ? 152 VAL B CA  1 
ATOM   4010 C C   . VAL B 1 126 ? -8.453  -34.164 64.269 1.00 58.08  ? 152 VAL B C   1 
ATOM   4011 O O   . VAL B 1 126 ? -8.545  -34.611 65.415 1.00 57.29  ? 152 VAL B O   1 
ATOM   4012 C CB  . VAL B 1 126 ? -6.806  -35.660 63.107 1.00 56.85  ? 152 VAL B CB  1 
ATOM   4013 C CG1 . VAL B 1 126 ? -7.967  -36.215 62.326 1.00 63.90  ? 152 VAL B CG1 1 
ATOM   4014 C CG2 . VAL B 1 126 ? -5.509  -35.698 62.308 1.00 62.01  ? 152 VAL B CG2 1 
ATOM   4015 N N   . VAL B 1 127 ? -9.475  -33.593 63.623 1.00 56.67  ? 153 VAL B N   1 
ATOM   4016 C CA  . VAL B 1 127 ? -10.821 -33.634 64.173 1.00 52.92  ? 153 VAL B CA  1 
ATOM   4017 C C   . VAL B 1 127 ? -11.222 -35.078 64.400 1.00 61.67  ? 153 VAL B C   1 
ATOM   4018 O O   . VAL B 1 127 ? -11.164 -35.907 63.483 1.00 58.00  ? 153 VAL B O   1 
ATOM   4019 C CB  . VAL B 1 127 ? -11.816 -32.926 63.242 1.00 62.39  ? 153 VAL B CB  1 
ATOM   4020 C CG1 . VAL B 1 127 ? -13.268 -33.281 63.636 1.00 58.85  ? 153 VAL B CG1 1 
ATOM   4021 C CG2 . VAL B 1 127 ? -11.597 -31.421 63.278 1.00 61.66  ? 153 VAL B CG2 1 
ATOM   4022 N N   . GLN B 1 128 ? -11.668 -35.379 65.613 1.00 55.58  ? 154 GLN B N   1 
ATOM   4023 C CA  . GLN B 1 128 ? -12.024 -36.740 65.948 1.00 57.45  ? 154 GLN B CA  1 
ATOM   4024 C C   . GLN B 1 128 ? -13.440 -37.064 65.480 1.00 57.16  ? 154 GLN B C   1 
ATOM   4025 O O   . GLN B 1 128 ? -14.358 -36.249 65.612 1.00 57.43  ? 154 GLN B O   1 
ATOM   4026 C CB  . GLN B 1 128 ? -11.922 -36.948 67.457 1.00 62.34  ? 154 GLN B CB  1 
ATOM   4027 C CG  . GLN B 1 128 ? -12.164 -38.378 67.848 1.00 66.02  ? 154 GLN B CG  1 
ATOM   4028 C CD  . GLN B 1 128 ? -12.180 -38.580 69.332 1.00 76.39  ? 154 GLN B CD  1 
ATOM   4029 O OE1 . GLN B 1 128 ? -12.267 -37.616 70.109 1.00 78.36  ? 154 GLN B OE1 1 
ATOM   4030 N NE2 . GLN B 1 128 ? -12.100 -39.841 69.749 1.00 78.03  ? 154 GLN B NE2 1 
ATOM   4031 N N   . LEU B 1 129 ? -13.624 -38.277 64.971 1.00 54.73  ? 155 LEU B N   1 
ATOM   4032 C CA  . LEU B 1 129 ? -14.937 -38.790 64.592 1.00 59.34  ? 155 LEU B CA  1 
ATOM   4033 C C   . LEU B 1 129 ? -15.508 -39.694 65.691 1.00 59.38  ? 155 LEU B C   1 
ATOM   4034 O O   . LEU B 1 129 ? -14.799 -40.540 66.241 1.00 56.96  ? 155 LEU B O   1 
ATOM   4035 C CB  . LEU B 1 129 ? -14.827 -39.561 63.273 1.00 56.87  ? 155 LEU B CB  1 
ATOM   4036 C CG  . LEU B 1 129 ? -16.032 -40.382 62.804 1.00 60.55  ? 155 LEU B CG  1 
ATOM   4037 C CD1 . LEU B 1 129 ? -16.954 -39.519 62.012 1.00 58.49  ? 155 LEU B CD1 1 
ATOM   4038 C CD2 . LEU B 1 129 ? -15.575 -41.545 61.960 1.00 64.32  ? 155 LEU B CD2 1 
ATOM   4039 N N   . PHE B 1 130 ? -16.797 -39.526 66.004 1.00 54.58  ? 156 PHE B N   1 
ATOM   4040 C CA  . PHE B 1 130 ? -17.450 -40.376 67.004 1.00 56.89  ? 156 PHE B CA  1 
ATOM   4041 C C   . PHE B 1 130 ? -18.353 -41.427 66.377 1.00 57.51  ? 156 PHE B C   1 
ATOM   4042 O O   . PHE B 1 130 ? -18.344 -42.582 66.794 1.00 62.46  ? 156 PHE B O   1 
ATOM   4043 C CB  . PHE B 1 130 ? -18.275 -39.523 67.992 1.00 52.58  ? 156 PHE B CB  1 
ATOM   4044 C CG  . PHE B 1 130 ? -17.454 -38.510 68.744 1.00 59.16  ? 156 PHE B CG  1 
ATOM   4045 C CD1 . PHE B 1 130 ? -16.540 -38.918 69.709 1.00 63.58  ? 156 PHE B CD1 1 
ATOM   4046 C CD2 . PHE B 1 130 ? -17.564 -37.151 68.465 1.00 56.04  ? 156 PHE B CD2 1 
ATOM   4047 C CE1 . PHE B 1 130 ? -15.757 -37.996 70.392 1.00 66.18  ? 156 PHE B CE1 1 
ATOM   4048 C CE2 . PHE B 1 130 ? -16.789 -36.212 69.157 1.00 55.00  ? 156 PHE B CE2 1 
ATOM   4049 C CZ  . PHE B 1 130 ? -15.881 -36.636 70.118 1.00 62.13  ? 156 PHE B CZ  1 
ATOM   4050 N N   . TYR B 1 131 ? -19.135 -41.062 65.380 1.00 54.25  ? 157 TYR B N   1 
ATOM   4051 C CA  . TYR B 1 131 ? -20.022 -42.008 64.733 1.00 57.84  ? 157 TYR B CA  1 
ATOM   4052 C C   . TYR B 1 131 ? -19.989 -41.749 63.239 1.00 55.91  ? 157 TYR B C   1 
ATOM   4053 O O   . TYR B 1 131 ? -19.921 -40.593 62.807 1.00 56.26  ? 157 TYR B O   1 
ATOM   4054 C CB  . TYR B 1 131 ? -21.469 -41.896 65.235 1.00 54.82  ? 157 TYR B CB  1 
ATOM   4055 C CG  . TYR B 1 131 ? -21.618 -41.887 66.732 1.00 60.13  ? 157 TYR B CG  1 
ATOM   4056 C CD1 . TYR B 1 131 ? -21.347 -43.031 67.491 1.00 63.29  ? 157 TYR B CD1 1 
ATOM   4057 C CD2 . TYR B 1 131 ? -22.043 -40.732 67.399 1.00 59.58  ? 157 TYR B CD2 1 
ATOM   4058 C CE1 . TYR B 1 131 ? -21.481 -43.020 68.883 1.00 62.29  ? 157 TYR B CE1 1 
ATOM   4059 C CE2 . TYR B 1 131 ? -22.176 -40.707 68.790 1.00 62.55  ? 157 TYR B CE2 1 
ATOM   4060 C CZ  . TYR B 1 131 ? -21.898 -41.859 69.525 1.00 65.59  ? 157 TYR B CZ  1 
ATOM   4061 O OH  . TYR B 1 131 ? -22.048 -41.844 70.896 1.00 62.47  ? 157 TYR B OH  1 
ATOM   4062 N N   . ALA B 1 132 ? -19.988 -42.831 62.464 1.00 56.41  ? 158 ALA B N   1 
ATOM   4063 C CA  . ALA B 1 132 ? -20.332 -42.802 61.050 1.00 57.18  ? 158 ALA B CA  1 
ATOM   4064 C C   . ALA B 1 132 ? -21.519 -43.721 60.846 1.00 56.61  ? 158 ALA B C   1 
ATOM   4065 O O   . ALA B 1 132 ? -21.490 -44.882 61.263 1.00 57.18  ? 158 ALA B O   1 
ATOM   4066 C CB  . ALA B 1 132 ? -19.167 -43.247 60.159 1.00 56.95  ? 158 ALA B CB  1 
ATOM   4067 N N   . PHE B 1 133 ? -22.551 -43.225 60.192 1.00 56.92  ? 159 PHE B N   1 
ATOM   4068 C CA  . PHE B 1 133 ? -23.668 -44.104 59.893 1.00 58.72  ? 159 PHE B CA  1 
ATOM   4069 C C   . PHE B 1 133 ? -24.292 -43.678 58.564 1.00 63.35  ? 159 PHE B C   1 
ATOM   4070 O O   . PHE B 1 133 ? -23.825 -42.748 57.893 1.00 58.57  ? 159 PHE B O   1 
ATOM   4071 C CB  . PHE B 1 133 ? -24.652 -44.131 61.059 1.00 57.62  ? 159 PHE B CB  1 
ATOM   4072 C CG  . PHE B 1 133 ? -25.270 -42.803 61.366 1.00 64.29  ? 159 PHE B CG  1 
ATOM   4073 C CD1 . PHE B 1 133 ? -24.591 -41.865 62.132 1.00 58.61  ? 159 PHE B CD1 1 
ATOM   4074 C CD2 . PHE B 1 133 ? -26.543 -42.493 60.893 1.00 62.77  ? 159 PHE B CD2 1 
ATOM   4075 C CE1 . PHE B 1 133 ? -25.162 -40.640 62.425 1.00 53.88  ? 159 PHE B CE1 1 
ATOM   4076 C CE2 . PHE B 1 133 ? -27.127 -41.272 61.182 1.00 63.72  ? 159 PHE B CE2 1 
ATOM   4077 C CZ  . PHE B 1 133 ? -26.431 -40.341 61.957 1.00 64.68  ? 159 PHE B CZ  1 
ATOM   4078 N N   . GLN B 1 134 ? -25.344 -44.386 58.167 1.00 59.55  ? 160 GLN B N   1 
ATOM   4079 C CA  . GLN B 1 134 ? -25.911 -44.161 56.850 1.00 61.62  ? 160 GLN B CA  1 
ATOM   4080 C C   . GLN B 1 134 ? -27.388 -44.481 56.882 1.00 65.77  ? 160 GLN B C   1 
ATOM   4081 O O   . GLN B 1 134 ? -27.886 -45.121 57.815 1.00 64.13  ? 160 GLN B O   1 
ATOM   4082 C CB  . GLN B 1 134 ? -25.221 -45.001 55.769 1.00 58.24  ? 160 GLN B CB  1 
ATOM   4083 C CG  . GLN B 1 134 ? -25.159 -46.510 56.035 1.00 61.63  ? 160 GLN B CG  1 
ATOM   4084 C CD  . GLN B 1 134 ? -24.286 -47.222 55.007 1.00 62.88  ? 160 GLN B CD  1 
ATOM   4085 O OE1 . GLN B 1 134 ? -24.527 -47.103 53.818 1.00 66.09  ? 160 GLN B OE1 1 
ATOM   4086 N NE2 . GLN B 1 134 ? -23.255 -47.941 55.461 1.00 61.10  ? 160 GLN B NE2 1 
ATOM   4087 N N   . ASP B 1 135 ? -28.093 -43.960 55.879 1.00 67.13  ? 161 ASP B N   1 
ATOM   4088 C CA  . ASP B 1 135 ? -29.423 -44.443 55.527 1.00 68.78  ? 161 ASP B CA  1 
ATOM   4089 C C   . ASP B 1 135 ? -29.464 -44.591 54.010 1.00 68.29  ? 161 ASP B C   1 
ATOM   4090 O O   . ASP B 1 135 ? -28.424 -44.458 53.353 1.00 64.17  ? 161 ASP B O   1 
ATOM   4091 C CB  . ASP B 1 135 ? -30.534 -43.525 56.077 1.00 63.39  ? 161 ASP B CB  1 
ATOM   4092 C CG  . ASP B 1 135 ? -30.439 -42.076 55.586 1.00 67.08  ? 161 ASP B CG  1 
ATOM   4093 O OD1 . ASP B 1 135 ? -30.084 -41.835 54.410 1.00 73.32  ? 161 ASP B OD1 1 
ATOM   4094 O OD2 . ASP B 1 135 ? -30.732 -41.163 56.395 1.00 67.88  ? 161 ASP B OD2 1 
ATOM   4095 N N   . ASP B 1 136 ? -30.640 -44.880 53.440 1.00 66.65  ? 162 ASP B N   1 
ATOM   4096 C CA  . ASP B 1 136 ? -30.685 -45.178 52.013 1.00 70.48  ? 162 ASP B CA  1 
ATOM   4097 C C   . ASP B 1 136 ? -30.317 -43.969 51.155 1.00 68.78  ? 162 ASP B C   1 
ATOM   4098 O O   . ASP B 1 136 ? -30.000 -44.148 49.976 1.00 75.36  ? 162 ASP B O   1 
ATOM   4099 C CB  . ASP B 1 136 ? -32.064 -45.722 51.629 1.00 72.87  ? 162 ASP B CB  1 
ATOM   4100 C CG  . ASP B 1 136 ? -33.136 -44.663 51.682 1.00 71.36  ? 162 ASP B CG  1 
ATOM   4101 O OD1 . ASP B 1 136 ? -33.041 -43.759 52.529 1.00 77.90  ? 162 ASP B OD1 1 
ATOM   4102 O OD2 . ASP B 1 136 ? -34.075 -44.726 50.869 1.00 88.62  ? 162 ASP B OD2 1 
ATOM   4103 N N   . ARG B 1 137 ? -30.310 -42.755 51.720 1.00 69.34  ? 163 ARG B N   1 
ATOM   4104 C CA  . ARG B 1 137 ? -29.955 -41.548 50.975 1.00 74.51  ? 163 ARG B CA  1 
ATOM   4105 C C   . ARG B 1 137 ? -28.619 -40.909 51.348 1.00 72.99  ? 163 ARG B C   1 
ATOM   4106 O O   . ARG B 1 137 ? -28.032 -40.223 50.504 1.00 71.52  ? 163 ARG B O   1 
ATOM   4107 C CB  . ARG B 1 137 ? -31.045 -40.484 51.130 1.00 75.60  ? 163 ARG B CB  1 
ATOM   4108 C CG  . ARG B 1 137 ? -32.440 -41.041 51.132 1.00 80.71  ? 163 ARG B CG  1 
ATOM   4109 C CD  . ARG B 1 137 ? -33.350 -40.177 50.305 1.00 89.05  ? 163 ARG B CD  1 
ATOM   4110 N NE  . ARG B 1 137 ? -34.736 -40.308 50.738 1.00 97.80  ? 163 ARG B NE  1 
ATOM   4111 C CZ  . ARG B 1 137 ? -35.740 -39.616 50.213 1.00 103.20 ? 163 ARG B CZ  1 
ATOM   4112 N NH1 . ARG B 1 137 ? -35.500 -38.751 49.232 1.00 105.67 ? 163 ARG B NH1 1 
ATOM   4113 N NH2 . ARG B 1 137 ? -36.978 -39.786 50.668 1.00 107.03 ? 163 ARG B NH2 1 
ATOM   4114 N N   . TYR B 1 138 ? -28.140 -41.052 52.585 1.00 66.34  ? 164 TYR B N   1 
ATOM   4115 C CA  . TYR B 1 138 ? -27.014 -40.239 53.032 1.00 68.61  ? 164 TYR B CA  1 
ATOM   4116 C C   . TYR B 1 138 ? -26.012 -41.033 53.863 1.00 70.91  ? 164 TYR B C   1 
ATOM   4117 O O   . TYR B 1 138 ? -26.385 -41.936 54.622 1.00 66.83  ? 164 TYR B O   1 
ATOM   4118 C CB  . TYR B 1 138 ? -27.498 -39.052 53.876 1.00 70.11  ? 164 TYR B CB  1 
ATOM   4119 C CG  . TYR B 1 138 ? -28.224 -37.978 53.100 1.00 70.00  ? 164 TYR B CG  1 
ATOM   4120 C CD1 . TYR B 1 138 ? -27.526 -36.945 52.494 1.00 73.27  ? 164 TYR B CD1 1 
ATOM   4121 C CD2 . TYR B 1 138 ? -29.610 -37.994 52.989 1.00 76.90  ? 164 TYR B CD2 1 
ATOM   4122 C CE1 . TYR B 1 138 ? -28.185 -35.959 51.781 1.00 77.19  ? 164 TYR B CE1 1 
ATOM   4123 C CE2 . TYR B 1 138 ? -30.281 -37.013 52.276 1.00 80.87  ? 164 TYR B CE2 1 
ATOM   4124 C CZ  . TYR B 1 138 ? -29.560 -35.997 51.674 1.00 81.11  ? 164 TYR B CZ  1 
ATOM   4125 O OH  . TYR B 1 138 ? -30.211 -35.010 50.966 1.00 91.87  ? 164 TYR B OH  1 
ATOM   4126 N N   . LEU B 1 139 ? -24.732 -40.665 53.727 1.00 64.81  ? 165 LEU B N   1 
ATOM   4127 C CA  . LEU B 1 139 ? -23.715 -40.944 54.730 1.00 63.85  ? 165 LEU B CA  1 
ATOM   4128 C C   . LEU B 1 139 ? -23.715 -39.832 55.784 1.00 70.36  ? 165 LEU B C   1 
ATOM   4129 O O   . LEU B 1 139 ? -24.017 -38.673 55.484 1.00 68.10  ? 165 LEU B O   1 
ATOM   4130 C CB  . LEU B 1 139 ? -22.331 -41.047 54.093 1.00 63.84  ? 165 LEU B CB  1 
ATOM   4131 C CG  . LEU B 1 139 ? -22.169 -42.091 52.996 1.00 65.11  ? 165 LEU B CG  1 
ATOM   4132 C CD1 . LEU B 1 139 ? -20.736 -42.174 52.609 1.00 62.12  ? 165 LEU B CD1 1 
ATOM   4133 C CD2 . LEU B 1 139 ? -22.656 -43.451 53.473 1.00 61.65  ? 165 LEU B CD2 1 
ATOM   4134 N N   . TYR B 1 140 ? -23.394 -40.191 57.034 1.00 65.56  ? 166 TYR B N   1 
ATOM   4135 C CA  . TYR B 1 140 ? -23.306 -39.211 58.117 1.00 64.09  ? 166 TYR B CA  1 
ATOM   4136 C C   . TYR B 1 140 ? -22.041 -39.437 58.928 1.00 60.00  ? 166 TYR B C   1 
ATOM   4137 O O   . TYR B 1 140 ? -21.738 -40.573 59.309 1.00 60.61  ? 166 TYR B O   1 
ATOM   4138 C CB  . TYR B 1 140 ? -24.500 -39.276 59.062 1.00 60.90  ? 166 TYR B CB  1 
ATOM   4139 C CG  . TYR B 1 140 ? -25.879 -39.187 58.436 1.00 63.31  ? 166 TYR B CG  1 
ATOM   4140 C CD1 . TYR B 1 140 ? -26.487 -40.311 57.907 1.00 61.75  ? 166 TYR B CD1 1 
ATOM   4141 C CD2 . TYR B 1 140 ? -26.605 -38.001 58.455 1.00 67.13  ? 166 TYR B CD2 1 
ATOM   4142 C CE1 . TYR B 1 140 ? -27.763 -40.259 57.380 1.00 65.52  ? 166 TYR B CE1 1 
ATOM   4143 C CE2 . TYR B 1 140 ? -27.895 -37.940 57.933 1.00 66.51  ? 166 TYR B CE2 1 
ATOM   4144 C CZ  . TYR B 1 140 ? -28.462 -39.076 57.394 1.00 66.80  ? 166 TYR B CZ  1 
ATOM   4145 O OH  . TYR B 1 140 ? -29.731 -39.051 56.871 1.00 68.59  ? 166 TYR B OH  1 
ATOM   4146 N N   . MET B 1 141 ? -21.319 -38.362 59.213 1.00 56.77  ? 167 MET B N   1 
ATOM   4147 C CA  . MET B 1 141 ? -20.151 -38.417 60.080 1.00 58.60  ? 167 MET B CA  1 
ATOM   4148 C C   . MET B 1 141 ? -20.349 -37.430 61.222 1.00 57.66  ? 167 MET B C   1 
ATOM   4149 O O   . MET B 1 141 ? -20.527 -36.228 60.985 1.00 57.07  ? 167 MET B O   1 
ATOM   4150 C CB  . MET B 1 141 ? -18.870 -38.112 59.308 1.00 58.34  ? 167 MET B CB  1 
ATOM   4151 C CG  . MET B 1 141 ? -18.445 -39.243 58.394 1.00 66.29  ? 167 MET B CG  1 
ATOM   4152 S SD  . MET B 1 141 ? -16.943 -38.829 57.485 1.00 68.77  ? 167 MET B SD  1 
ATOM   4153 C CE  . MET B 1 141 ? -17.659 -37.738 56.280 1.00 62.38  ? 167 MET B CE  1 
ATOM   4154 N N   . VAL B 1 142 ? -20.346 -37.941 62.450 1.00 52.82  ? 168 VAL B N   1 
ATOM   4155 C CA  . VAL B 1 142 ? -20.556 -37.132 63.648 1.00 51.24  ? 168 VAL B CA  1 
ATOM   4156 C C   . VAL B 1 142 ? -19.192 -36.872 64.280 1.00 51.74  ? 168 VAL B C   1 
ATOM   4157 O O   . VAL B 1 142 ? -18.557 -37.793 64.802 1.00 54.22  ? 168 VAL B O   1 
ATOM   4158 C CB  . VAL B 1 142 ? -21.506 -37.822 64.631 1.00 55.59  ? 168 VAL B CB  1 
ATOM   4159 C CG1 . VAL B 1 142 ? -21.658 -36.986 65.935 1.00 51.90  ? 168 VAL B CG1 1 
ATOM   4160 C CG2 . VAL B 1 142 ? -22.873 -38.056 63.957 1.00 52.67  ? 168 VAL B CG2 1 
ATOM   4161 N N   . MET B 1 143 ? -18.752 -35.613 64.243 1.00 53.02  ? 169 MET B N   1 
ATOM   4162 C CA  . MET B 1 143 ? -17.421 -35.171 64.641 1.00 55.03  ? 169 MET B CA  1 
ATOM   4163 C C   . MET B 1 143 ? -17.505 -34.225 65.831 1.00 55.59  ? 169 MET B C   1 
ATOM   4164 O O   . MET B 1 143 ? -18.561 -33.659 66.134 1.00 55.84  ? 169 MET B O   1 
ATOM   4165 C CB  . MET B 1 143 ? -16.706 -34.401 63.529 1.00 54.95  ? 169 MET B CB  1 
ATOM   4166 C CG  . MET B 1 143 ? -16.401 -35.145 62.261 1.00 63.54  ? 169 MET B CG  1 
ATOM   4167 S SD  . MET B 1 143 ? -16.140 -33.939 60.921 1.00 61.39  ? 169 MET B SD  1 
ATOM   4168 C CE  . MET B 1 143 ? -17.834 -33.560 60.472 1.00 56.13  ? 169 MET B CE  1 
ATOM   4169 N N   . GLU B 1 144 ? -16.360 -34.013 66.473 1.00 54.88  ? 170 GLU B N   1 
ATOM   4170 C CA  . GLU B 1 144 ? -16.278 -32.964 67.471 1.00 58.52  ? 170 GLU B CA  1 
ATOM   4171 C C   . GLU B 1 144 ? -16.447 -31.605 66.815 1.00 60.01  ? 170 GLU B C   1 
ATOM   4172 O O   . GLU B 1 144 ? -15.884 -31.327 65.751 1.00 55.23  ? 170 GLU B O   1 
ATOM   4173 C CB  . GLU B 1 144 ? -14.960 -33.036 68.245 1.00 59.39  ? 170 GLU B CB  1 
ATOM   4174 C CG  . GLU B 1 144 ? -13.709 -33.082 67.411 1.00 64.83  ? 170 GLU B CG  1 
ATOM   4175 C CD  . GLU B 1 144 ? -12.450 -33.089 68.291 1.00 69.28  ? 170 GLU B CD  1 
ATOM   4176 O OE1 . GLU B 1 144 ? -12.584 -32.741 69.494 1.00 69.77  ? 170 GLU B OE1 1 
ATOM   4177 O OE2 . GLU B 1 144 ? -11.344 -33.419 67.782 1.00 57.81  ? 170 GLU B OE2 1 
ATOM   4178 N N   . TYR B 1 145 ? -17.222 -30.746 67.475 1.00 60.92  ? 171 TYR B N   1 
ATOM   4179 C CA  . TYR B 1 145 ? -17.499 -29.414 66.961 1.00 60.36  ? 171 TYR B CA  1 
ATOM   4180 C C   . TYR B 1 145 ? -16.307 -28.517 67.237 1.00 58.08  ? 171 TYR B C   1 
ATOM   4181 O O   . TYR B 1 145 ? -15.817 -28.466 68.365 1.00 57.55  ? 171 TYR B O   1 
ATOM   4182 C CB  . TYR B 1 145 ? -18.762 -28.855 67.619 1.00 60.77  ? 171 TYR B CB  1 
ATOM   4183 C CG  . TYR B 1 145 ? -19.085 -27.418 67.287 1.00 62.93  ? 171 TYR B CG  1 
ATOM   4184 C CD1 . TYR B 1 145 ? -19.053 -26.956 65.967 1.00 59.48  ? 171 TYR B CD1 1 
ATOM   4185 C CD2 . TYR B 1 145 ? -19.469 -26.529 68.293 1.00 62.05  ? 171 TYR B CD2 1 
ATOM   4186 C CE1 . TYR B 1 145 ? -19.356 -25.639 65.667 1.00 60.15  ? 171 TYR B CE1 1 
ATOM   4187 C CE2 . TYR B 1 145 ? -19.772 -25.204 68.002 1.00 62.37  ? 171 TYR B CE2 1 
ATOM   4188 C CZ  . TYR B 1 145 ? -19.718 -24.768 66.685 1.00 64.08  ? 171 TYR B CZ  1 
ATOM   4189 O OH  . TYR B 1 145 ? -20.020 -23.463 66.387 1.00 59.30  ? 171 TYR B OH  1 
ATOM   4190 N N   . MET B 1 146 ? -15.839 -27.810 66.208 1.00 58.75  ? 172 MET B N   1 
ATOM   4191 C CA  . MET B 1 146 ? -14.704 -26.901 66.334 1.00 59.34  ? 172 MET B CA  1 
ATOM   4192 C C   . MET B 1 146 ? -15.231 -25.473 66.320 1.00 62.82  ? 172 MET B C   1 
ATOM   4193 O O   . MET B 1 146 ? -15.347 -24.863 65.249 1.00 65.53  ? 172 MET B O   1 
ATOM   4194 C CB  . MET B 1 146 ? -13.699 -27.126 65.200 1.00 61.57  ? 172 MET B CB  1 
ATOM   4195 C CG  . MET B 1 146 ? -13.100 -28.515 65.192 1.00 61.02  ? 172 MET B CG  1 
ATOM   4196 S SD  . MET B 1 146 ? -11.972 -28.746 66.584 1.00 64.19  ? 172 MET B SD  1 
ATOM   4197 C CE  . MET B 1 146 ? -10.623 -27.740 66.000 1.00 65.83  ? 172 MET B CE  1 
ATOM   4198 N N   . PRO B 1 147 ? -15.535 -24.880 67.480 1.00 63.69  ? 173 PRO B N   1 
ATOM   4199 C CA  . PRO B 1 147 ? -16.295 -23.620 67.494 1.00 62.90  ? 173 PRO B CA  1 
ATOM   4200 C C   . PRO B 1 147 ? -15.490 -22.389 67.127 1.00 61.90  ? 173 PRO B C   1 
ATOM   4201 O O   . PRO B 1 147 ? -16.087 -21.323 66.945 1.00 64.01  ? 173 PRO B O   1 
ATOM   4202 C CB  . PRO B 1 147 ? -16.797 -23.536 68.934 1.00 62.67  ? 173 PRO B CB  1 
ATOM   4203 C CG  . PRO B 1 147 ? -15.730 -24.239 69.730 1.00 65.65  ? 173 PRO B CG  1 
ATOM   4204 C CD  . PRO B 1 147 ? -15.200 -25.343 68.837 1.00 60.60  ? 173 PRO B CD  1 
ATOM   4205 N N   . GLY B 1 148 ? -14.167 -22.479 67.031 1.00 62.13  ? 174 GLY B N   1 
ATOM   4206 C CA  . GLY B 1 148 ? -13.390 -21.324 66.594 1.00 60.56  ? 174 GLY B CA  1 
ATOM   4207 C C   . GLY B 1 148 ? -13.538 -20.944 65.126 1.00 62.90  ? 174 GLY B C   1 
ATOM   4208 O O   . GLY B 1 148 ? -12.918 -19.970 64.689 1.00 62.17  ? 174 GLY B O   1 
ATOM   4209 N N   . GLY B 1 149 ? -14.306 -21.698 64.333 1.00 61.60  ? 175 GLY B N   1 
ATOM   4210 C CA  . GLY B 1 149 ? -14.392 -21.406 62.914 1.00 63.05  ? 175 GLY B CA  1 
ATOM   4211 C C   . GLY B 1 149 ? -13.128 -21.861 62.200 1.00 63.34  ? 175 GLY B C   1 
ATOM   4212 O O   . GLY B 1 149 ? -12.255 -22.528 62.775 1.00 60.59  ? 175 GLY B O   1 
ATOM   4213 N N   . ASP B 1 150 ? -13.015 -21.470 60.935 1.00 62.51  ? 176 ASP B N   1 
ATOM   4214 C CA  . ASP B 1 150 ? -11.874 -21.861 60.119 1.00 63.67  ? 176 ASP B CA  1 
ATOM   4215 C C   . ASP B 1 150 ? -10.960 -20.664 59.866 1.00 64.48  ? 176 ASP B C   1 
ATOM   4216 O O   . ASP B 1 150 ? -11.203 -19.541 60.319 1.00 63.14  ? 176 ASP B O   1 
ATOM   4217 C CB  . ASP B 1 150 ? -12.332 -22.481 58.798 1.00 62.63  ? 176 ASP B CB  1 
ATOM   4218 C CG  . ASP B 1 150 ? -13.138 -21.510 57.935 1.00 68.53  ? 176 ASP B CG  1 
ATOM   4219 O OD1 . ASP B 1 150 ? -13.277 -20.323 58.318 1.00 70.50  ? 176 ASP B OD1 1 
ATOM   4220 O OD2 . ASP B 1 150 ? -13.604 -21.926 56.849 1.00 63.50  ? 176 ASP B OD2 1 
ATOM   4221 N N   . LEU B 1 151 ? -9.882  -20.917 59.135 1.00 61.13  ? 177 LEU B N   1 
ATOM   4222 C CA  . LEU B 1 151 ? -8.920  -19.856 58.884 1.00 63.95  ? 177 LEU B CA  1 
ATOM   4223 C C   . LEU B 1 151 ? -9.364  -18.882 57.797 1.00 66.57  ? 177 LEU B C   1 
ATOM   4224 O O   . LEU B 1 151 ? -8.857  -17.754 57.767 1.00 67.22  ? 177 LEU B O   1 
ATOM   4225 C CB  . LEU B 1 151 ? -7.550  -20.465 58.611 1.00 59.31  ? 177 LEU B CB  1 
ATOM   4226 C CG  . LEU B 1 151 ? -7.111  -20.745 60.050 1.00 66.60  ? 177 LEU B CG  1 
ATOM   4227 C CD1 . LEU B 1 151 ? -7.245  -22.202 60.498 1.00 64.12  ? 177 LEU B CD1 1 
ATOM   4228 C CD2 . LEU B 1 151 ? -5.724  -20.204 60.267 1.00 64.37  ? 177 LEU B CD2 1 
ATOM   4229 N N   . VAL B 1 152 ? -10.295 -19.274 56.913 1.00 65.84  ? 178 VAL B N   1 
ATOM   4230 C CA  . VAL B 1 152 ? -10.920 -18.293 56.024 1.00 63.31  ? 178 VAL B CA  1 
ATOM   4231 C C   . VAL B 1 152 ? -11.562 -17.191 56.852 1.00 64.24  ? 178 VAL B C   1 
ATOM   4232 O O   . VAL B 1 152 ? -11.356 -15.998 56.607 1.00 68.25  ? 178 VAL B O   1 
ATOM   4233 C CB  . VAL B 1 152 ? -11.959 -18.960 55.098 1.00 68.15  ? 178 VAL B CB  1 
ATOM   4234 C CG1 . VAL B 1 152 ? -12.712 -17.899 54.273 1.00 64.94  ? 178 VAL B CG1 1 
ATOM   4235 C CG2 . VAL B 1 152 ? -11.316 -19.961 54.156 1.00 65.05  ? 178 VAL B CG2 1 
ATOM   4236 N N   . ASN B 1 153 ? -12.340 -17.584 57.860 1.00 66.87  ? 179 ASN B N   1 
ATOM   4237 C CA  . ASN B 1 153 ? -13.040 -16.622 58.707 1.00 64.25  ? 179 ASN B CA  1 
ATOM   4238 C C   . ASN B 1 153 ? -12.071 -15.802 59.557 1.00 68.23  ? 179 ASN B C   1 
ATOM   4239 O O   . ASN B 1 153 ? -12.303 -14.611 59.790 1.00 73.37  ? 179 ASN B O   1 
ATOM   4240 C CB  . ASN B 1 153 ? -14.057 -17.356 59.571 1.00 66.44  ? 179 ASN B CB  1 
ATOM   4241 C CG  . ASN B 1 153 ? -14.820 -16.425 60.486 1.00 72.76  ? 179 ASN B CG  1 
ATOM   4242 O OD1 . ASN B 1 153 ? -14.535 -16.339 61.682 1.00 70.94  ? 179 ASN B OD1 1 
ATOM   4243 N ND2 . ASN B 1 153 ? -15.802 -15.728 59.931 1.00 78.37  ? 179 ASN B ND2 1 
ATOM   4244 N N   . LEU B 1 154 ? -10.995 -16.416 60.054 1.00 67.56  ? 180 LEU B N   1 
ATOM   4245 C CA  . LEU B 1 154 ? -10.006 -15.645 60.807 1.00 66.69  ? 180 LEU B CA  1 
ATOM   4246 C C   . LEU B 1 154 ? -9.381  -14.557 59.938 1.00 71.45  ? 180 LEU B C   1 
ATOM   4247 O O   . LEU B 1 154 ? -9.278  -13.398 60.356 1.00 74.34  ? 180 LEU B O   1 
ATOM   4248 C CB  . LEU B 1 154 ? -8.920  -16.558 61.374 1.00 63.27  ? 180 LEU B CB  1 
ATOM   4249 C CG  . LEU B 1 154 ? -7.920  -15.853 62.305 1.00 69.54  ? 180 LEU B CG  1 
ATOM   4250 C CD1 . LEU B 1 154 ? -7.632  -16.669 63.568 1.00 69.47  ? 180 LEU B CD1 1 
ATOM   4251 C CD2 . LEU B 1 154 ? -6.622  -15.559 61.585 1.00 68.59  ? 180 LEU B CD2 1 
ATOM   4252 N N   . MET B 1 155 ? -8.950  -14.910 58.728 1.00 66.69  ? 181 MET B N   1 
ATOM   4253 C CA  . MET B 1 155 ? -8.337  -13.908 57.855 1.00 74.25  ? 181 MET B CA  1 
ATOM   4254 C C   . MET B 1 155 ? -9.331  -12.822 57.440 1.00 75.40  ? 181 MET B C   1 
ATOM   4255 O O   . MET B 1 155 ? -8.936  -11.662 57.287 1.00 77.87  ? 181 MET B O   1 
ATOM   4256 C CB  . MET B 1 155 ? -7.725  -14.576 56.617 1.00 66.67  ? 181 MET B CB  1 
ATOM   4257 C CG  . MET B 1 155 ? -6.440  -15.360 56.920 1.00 65.98  ? 181 MET B CG  1 
ATOM   4258 S SD  . MET B 1 155 ? -5.664  -16.131 55.472 1.00 73.84  ? 181 MET B SD  1 
ATOM   4259 C CE  . MET B 1 155 ? -6.611  -17.644 55.345 1.00 69.96  ? 181 MET B CE  1 
ATOM   4260 N N   . SER B 1 156 ? -10.615 -13.166 57.261 1.00 70.32  ? 182 SER B N   1 
ATOM   4261 C CA  . SER B 1 156 ? -11.607 -12.147 56.921 1.00 75.31  ? 182 SER B CA  1 
ATOM   4262 C C   . SER B 1 156 ? -11.804 -11.140 58.043 1.00 77.89  ? 182 SER B C   1 
ATOM   4263 O O   . SER B 1 156 ? -12.195 -9.998  57.780 1.00 80.60  ? 182 SER B O   1 
ATOM   4264 C CB  . SER B 1 156 ? -12.975 -12.775 56.622 1.00 67.57  ? 182 SER B CB  1 
ATOM   4265 O OG  . SER B 1 156 ? -12.952 -13.567 55.454 1.00 76.14  ? 182 SER B OG  1 
ATOM   4266 N N   . ASN B 1 157 ? -11.558 -11.537 59.289 1.00 76.27  ? 183 ASN B N   1 
ATOM   4267 C CA  . ASN B 1 157 ? -11.888 -10.696 60.425 1.00 75.12  ? 183 ASN B CA  1 
ATOM   4268 C C   . ASN B 1 157 ? -10.692 -10.013 61.059 1.00 76.65  ? 183 ASN B C   1 
ATOM   4269 O O   . ASN B 1 157 ? -10.890 -9.105  61.870 1.00 79.63  ? 183 ASN B O   1 
ATOM   4270 C CB  . ASN B 1 157 ? -12.628 -11.523 61.488 1.00 78.29  ? 183 ASN B CB  1 
ATOM   4271 C CG  . ASN B 1 157 ? -13.972 -12.031 60.998 1.00 78.91  ? 183 ASN B CG  1 
ATOM   4272 O OD1 . ASN B 1 157 ? -14.561 -11.465 60.081 1.00 83.01  ? 183 ASN B OD1 1 
ATOM   4273 N ND2 . ASN B 1 157 ? -14.450 -13.115 61.594 1.00 80.90  ? 183 ASN B ND2 1 
ATOM   4274 N N   . TYR B 1 158 ? -9.471  -10.426 60.724 1.00 77.36  ? 184 TYR B N   1 
ATOM   4275 C CA  . TYR B 1 158 ? -8.258  -9.877  61.312 1.00 77.84  ? 184 TYR B CA  1 
ATOM   4276 C C   . TYR B 1 158 ? -7.266  -9.612  60.202 1.00 77.35  ? 184 TYR B C   1 
ATOM   4277 O O   . TYR B 1 158 ? -7.258  -10.286 59.179 1.00 81.12  ? 184 TYR B O   1 
ATOM   4278 C CB  . TYR B 1 158 ? -7.590  -10.810 62.353 1.00 74.29  ? 184 TYR B CB  1 
ATOM   4279 C CG  . TYR B 1 158 ? -8.425  -11.100 63.576 1.00 77.23  ? 184 TYR B CG  1 
ATOM   4280 C CD1 . TYR B 1 158 ? -9.351  -12.136 63.575 1.00 75.81  ? 184 TYR B CD1 1 
ATOM   4281 C CD2 . TYR B 1 158 ? -8.297  -10.336 64.728 1.00 74.79  ? 184 TYR B CD2 1 
ATOM   4282 C CE1 . TYR B 1 158 ? -10.124 -12.406 64.675 1.00 73.49  ? 184 TYR B CE1 1 
ATOM   4283 C CE2 . TYR B 1 158 ? -9.074  -10.595 65.842 1.00 74.08  ? 184 TYR B CE2 1 
ATOM   4284 C CZ  . TYR B 1 158 ? -9.987  -11.638 65.810 1.00 79.27  ? 184 TYR B CZ  1 
ATOM   4285 O OH  . TYR B 1 158 ? -10.767 -11.918 66.915 1.00 87.06  ? 184 TYR B OH  1 
ATOM   4286 N N   . ASP B 1 159 ? -6.417  -8.634  60.413 1.00 81.38  ? 185 ASP B N   1 
ATOM   4287 C CA  . ASP B 1 159 ? -5.242  -8.477  59.578 1.00 83.43  ? 185 ASP B CA  1 
ATOM   4288 C C   . ASP B 1 159 ? -4.109  -9.126  60.355 1.00 80.87  ? 185 ASP B C   1 
ATOM   4289 O O   . ASP B 1 159 ? -3.868  -8.781  61.516 1.00 81.88  ? 185 ASP B O   1 
ATOM   4290 C CB  . ASP B 1 159 ? -4.986  -7.010  59.235 1.00 85.45  ? 185 ASP B CB  1 
ATOM   4291 C CG  . ASP B 1 159 ? -4.727  -6.821  57.746 1.00 102.87 ? 185 ASP B CG  1 
ATOM   4292 O OD1 . ASP B 1 159 ? -3.853  -7.538  57.188 1.00 104.52 ? 185 ASP B OD1 1 
ATOM   4293 O OD2 . ASP B 1 159 ? -5.438  -6.012  57.122 1.00 106.76 ? 185 ASP B OD2 1 
ATOM   4294 N N   . VAL B 1 160 ? -3.464  -10.101 59.725 1.00 79.04  ? 186 VAL B N   1 
ATOM   4295 C CA  . VAL B 1 160 ? -2.710  -11.133 60.439 1.00 76.02  ? 186 VAL B CA  1 
ATOM   4296 C C   . VAL B 1 160 ? -1.263  -10.685 60.545 1.00 75.06  ? 186 VAL B C   1 
ATOM   4297 O O   . VAL B 1 160 ? -0.532  -10.707 59.532 1.00 74.98  ? 186 VAL B O   1 
ATOM   4298 C CB  . VAL B 1 160 ? -2.838  -12.486 59.723 1.00 74.78  ? 186 VAL B CB  1 
ATOM   4299 C CG1 . VAL B 1 160 ? -2.051  -13.564 60.462 1.00 71.15  ? 186 VAL B CG1 1 
ATOM   4300 C CG2 . VAL B 1 160 ? -4.312  -12.872 59.591 1.00 75.70  ? 186 VAL B CG2 1 
ATOM   4301 N N   . PRO B 1 161 ? -0.777  -10.314 61.735 1.00 74.78  ? 187 PRO B N   1 
ATOM   4302 C CA  . PRO B 1 161 ? 0.639   -9.980  61.887 1.00 72.94  ? 187 PRO B CA  1 
ATOM   4303 C C   . PRO B 1 161 ? 1.494   -11.228 61.804 1.00 73.73  ? 187 PRO B C   1 
ATOM   4304 O O   . PRO B 1 161 ? 1.010   -12.349 61.968 1.00 75.98  ? 187 PRO B O   1 
ATOM   4305 C CB  . PRO B 1 161 ? 0.713   -9.351  63.275 1.00 74.96  ? 187 PRO B CB  1 
ATOM   4306 C CG  . PRO B 1 161 ? -0.431  -9.979  64.017 1.00 75.83  ? 187 PRO B CG  1 
ATOM   4307 C CD  . PRO B 1 161 ? -1.516  -10.230 63.009 1.00 70.70  ? 187 PRO B CD  1 
ATOM   4308 N N   . GLU B 1 162 ? 2.788   -11.014 61.541 1.00 71.15  ? 188 GLU B N   1 
ATOM   4309 C CA  . GLU B 1 162 ? 3.700   -12.138 61.349 1.00 74.12  ? 188 GLU B CA  1 
ATOM   4310 C C   . GLU B 1 162 ? 3.811   -13.009 62.599 1.00 70.71  ? 188 GLU B C   1 
ATOM   4311 O O   . GLU B 1 162 ? 3.990   -14.230 62.491 1.00 70.21  ? 188 GLU B O   1 
ATOM   4312 C CB  . GLU B 1 162 ? 5.083   -11.630 60.940 1.00 73.23  ? 188 GLU B CB  1 
ATOM   4313 C CG  . GLU B 1 162 ? 5.062   -10.703 59.748 1.00 77.40  ? 188 GLU B CG  1 
ATOM   4314 C CD  . GLU B 1 162 ? 6.338   -10.791 58.927 1.00 82.01  ? 188 GLU B CD  1 
ATOM   4315 O OE1 . GLU B 1 162 ? 7.213   -11.610 59.282 1.00 78.14  ? 188 GLU B OE1 1 
ATOM   4316 O OE2 . GLU B 1 162 ? 6.449   -10.061 57.912 1.00 89.83  ? 188 GLU B OE2 1 
ATOM   4317 N N   . LYS B 1 163 ? 3.750   -12.407 63.788 1.00 72.00  ? 189 LYS B N   1 
ATOM   4318 C CA  . LYS B 1 163 ? 3.757   -13.216 65.005 1.00 72.46  ? 189 LYS B CA  1 
ATOM   4319 C C   . LYS B 1 163 ? 2.618   -14.242 64.984 1.00 69.81  ? 189 LYS B C   1 
ATOM   4320 O O   . LYS B 1 163 ? 2.806   -15.400 65.382 1.00 68.93  ? 189 LYS B O   1 
ATOM   4321 C CB  . LYS B 1 163 ? 3.688   -12.307 66.234 1.00 65.55  ? 189 LYS B CB  1 
ATOM   4322 N N   . TRP B 1 164 ? 1.452   -13.862 64.447 1.00 69.51  ? 190 TRP B N   1 
ATOM   4323 C CA  . TRP B 1 164 ? 0.345   -14.811 64.337 1.00 66.02  ? 190 TRP B CA  1 
ATOM   4324 C C   . TRP B 1 164 ? 0.600   -15.833 63.236 1.00 65.92  ? 190 TRP B C   1 
ATOM   4325 O O   . TRP B 1 164 ? 0.387   -17.037 63.426 1.00 64.61  ? 190 TRP B O   1 
ATOM   4326 C CB  . TRP B 1 164 ? -0.956  -14.076 64.053 1.00 66.24  ? 190 TRP B CB  1 
ATOM   4327 C CG  . TRP B 1 164 ? -1.489  -13.287 65.172 1.00 66.15  ? 190 TRP B CG  1 
ATOM   4328 C CD1 . TRP B 1 164 ? -0.828  -12.891 66.292 1.00 67.39  ? 190 TRP B CD1 1 
ATOM   4329 C CD2 . TRP B 1 164 ? -2.826  -12.794 65.294 1.00 68.96  ? 190 TRP B CD2 1 
ATOM   4330 N NE1 . TRP B 1 164 ? -1.675  -12.181 67.110 1.00 66.77  ? 190 TRP B NE1 1 
ATOM   4331 C CE2 . TRP B 1 164 ? -2.908  -12.108 66.514 1.00 65.26  ? 190 TRP B CE2 1 
ATOM   4332 C CE3 . TRP B 1 164 ? -3.967  -12.875 64.483 1.00 69.00  ? 190 TRP B CE3 1 
ATOM   4333 C CZ2 . TRP B 1 164 ? -4.079  -11.497 66.946 1.00 69.99  ? 190 TRP B CZ2 1 
ATOM   4334 C CZ3 . TRP B 1 164 ? -5.125  -12.269 64.911 1.00 68.91  ? 190 TRP B CZ3 1 
ATOM   4335 C CH2 . TRP B 1 164 ? -5.175  -11.590 66.131 1.00 70.28  ? 190 TRP B CH2 1 
ATOM   4336 N N   . ALA B 1 165 ? 1.026   -15.360 62.063 1.00 68.93  ? 191 ALA B N   1 
ATOM   4337 C CA  . ALA B 1 165 ? 1.289   -16.248 60.934 1.00 65.23  ? 191 ALA B CA  1 
ATOM   4338 C C   . ALA B 1 165 ? 2.341   -17.296 61.275 1.00 67.86  ? 191 ALA B C   1 
ATOM   4339 O O   . ALA B 1 165 ? 2.279   -18.429 60.780 1.00 65.25  ? 191 ALA B O   1 
ATOM   4340 C CB  . ALA B 1 165 ? 1.720   -15.424 59.722 1.00 67.86  ? 191 ALA B CB  1 
ATOM   4341 N N   . LYS B 1 166 ? 3.347   -16.914 62.072 1.00 69.50  ? 192 LYS B N   1 
ATOM   4342 C CA  . LYS B 1 166 ? 4.330   -17.864 62.590 1.00 70.27  ? 192 LYS B CA  1 
ATOM   4343 C C   . LYS B 1 166 ? 3.645   -19.049 63.274 1.00 66.26  ? 192 LYS B C   1 
ATOM   4344 O O   . LYS B 1 166 ? 3.965   -20.214 63.014 1.00 65.84  ? 192 LYS B O   1 
ATOM   4345 C CB  . LYS B 1 166 ? 5.262   -17.144 63.573 1.00 70.02  ? 192 LYS B CB  1 
ATOM   4346 C CG  . LYS B 1 166 ? 6.656   -16.840 63.043 1.00 75.78  ? 192 LYS B CG  1 
ATOM   4347 C CD  . LYS B 1 166 ? 7.516   -16.120 64.104 1.00 75.61  ? 192 LYS B CD  1 
ATOM   4348 C CE  . LYS B 1 166 ? 7.600   -14.608 63.864 1.00 75.13  ? 192 LYS B CE  1 
ATOM   4349 N NZ  . LYS B 1 166 ? 8.301   -13.911 64.985 1.00 86.28  ? 192 LYS B NZ  1 
ATOM   4350 N N   . PHE B 1 167 ? 2.697   -18.752 64.160 1.00 62.88  ? 193 PHE B N   1 
ATOM   4351 C CA  . PHE B 1 167 ? 2.043   -19.765 64.989 1.00 64.91  ? 193 PHE B CA  1 
ATOM   4352 C C   . PHE B 1 167 ? 1.169   -20.699 64.150 1.00 65.38  ? 193 PHE B C   1 
ATOM   4353 O O   . PHE B 1 167 ? 1.294   -21.933 64.231 1.00 62.93  ? 193 PHE B O   1 
ATOM   4354 C CB  . PHE B 1 167 ? 1.226   -19.042 66.068 1.00 59.70  ? 193 PHE B CB  1 
ATOM   4355 C CG  . PHE B 1 167 ? 0.342   -19.929 66.883 1.00 65.48  ? 193 PHE B CG  1 
ATOM   4356 C CD1 . PHE B 1 167 ? -0.917  -20.294 66.427 1.00 63.60  ? 193 PHE B CD1 1 
ATOM   4357 C CD2 . PHE B 1 167 ? 0.754   -20.375 68.127 1.00 56.34  ? 193 PHE B CD2 1 
ATOM   4358 C CE1 . PHE B 1 167 ? -1.738  -21.106 67.196 1.00 62.61  ? 193 PHE B CE1 1 
ATOM   4359 C CE2 . PHE B 1 167 ? -0.055  -21.192 68.886 1.00 60.64  ? 193 PHE B CE2 1 
ATOM   4360 C CZ  . PHE B 1 167 ? -1.311  -21.547 68.428 1.00 59.63  ? 193 PHE B CZ  1 
ATOM   4361 N N   . TYR B 1 168 ? 0.288   -20.127 63.319 1.00 66.23  ? 194 TYR B N   1 
ATOM   4362 C CA  . TYR B 1 168 ? -0.590  -20.945 62.485 1.00 63.07  ? 194 TYR B CA  1 
ATOM   4363 C C   . TYR B 1 168 ? 0.180   -21.742 61.438 1.00 60.75  ? 194 TYR B C   1 
ATOM   4364 O O   . TYR B 1 168 ? -0.206  -22.872 61.107 1.00 59.42  ? 194 TYR B O   1 
ATOM   4365 C CB  . TYR B 1 168 ? -1.633  -20.066 61.808 1.00 63.80  ? 194 TYR B CB  1 
ATOM   4366 C CG  . TYR B 1 168 ? -2.581  -19.406 62.771 1.00 60.68  ? 194 TYR B CG  1 
ATOM   4367 C CD1 . TYR B 1 168 ? -3.393  -20.162 63.601 1.00 64.34  ? 194 TYR B CD1 1 
ATOM   4368 C CD2 . TYR B 1 168 ? -2.679  -18.024 62.844 1.00 64.30  ? 194 TYR B CD2 1 
ATOM   4369 C CE1 . TYR B 1 168 ? -4.282  -19.561 64.481 1.00 58.58  ? 194 TYR B CE1 1 
ATOM   4370 C CE2 . TYR B 1 168 ? -3.569  -17.413 63.723 1.00 63.79  ? 194 TYR B CE2 1 
ATOM   4371 C CZ  . TYR B 1 168 ? -4.358  -18.184 64.542 1.00 63.86  ? 194 TYR B CZ  1 
ATOM   4372 O OH  . TYR B 1 168 ? -5.230  -17.581 65.423 1.00 61.45  ? 194 TYR B OH  1 
ATOM   4373 N N   . THR B 1 169 ? 1.259   -21.185 60.891 1.00 64.66  ? 195 THR B N   1 
ATOM   4374 C CA  . THR B 1 169 ? 2.058   -21.957 59.945 1.00 63.12  ? 195 THR B CA  1 
ATOM   4375 C C   . THR B 1 169 ? 2.680   -23.163 60.623 1.00 57.88  ? 195 THR B C   1 
ATOM   4376 O O   . THR B 1 169 ? 2.661   -24.279 60.084 1.00 59.36  ? 195 THR B O   1 
ATOM   4377 C CB  . THR B 1 169 ? 3.153   -21.090 59.335 1.00 63.09  ? 195 THR B CB  1 
ATOM   4378 O OG1 . THR B 1 169 ? 2.545   -19.980 58.685 1.00 64.08  ? 195 THR B OG1 1 
ATOM   4379 C CG2 . THR B 1 169 ? 3.952   -21.904 58.324 1.00 53.49  ? 195 THR B CG2 1 
ATOM   4380 N N   . ALA B 1 170 ? 3.254   -22.942 61.805 1.00 60.64  ? 196 ALA B N   1 
ATOM   4381 C CA  . ALA B 1 170 ? 3.855   -24.029 62.570 1.00 61.33  ? 196 ALA B CA  1 
ATOM   4382 C C   . ALA B 1 170 ? 2.833   -25.106 62.904 1.00 53.88  ? 196 ALA B C   1 
ATOM   4383 O O   . ALA B 1 170 ? 3.123   -26.302 62.782 1.00 55.12  ? 196 ALA B O   1 
ATOM   4384 C CB  . ALA B 1 170 ? 4.480   -23.469 63.850 1.00 60.88  ? 196 ALA B CB  1 
ATOM   4385 N N   . GLU B 1 171 ? 1.623   -24.709 63.312 1.00 53.61  ? 197 GLU B N   1 
ATOM   4386 C CA  . GLU B 1 171 ? 0.624   -25.724 63.656 1.00 59.79  ? 197 GLU B CA  1 
ATOM   4387 C C   . GLU B 1 171 ? 0.220   -26.541 62.432 1.00 58.42  ? 197 GLU B C   1 
ATOM   4388 O O   . GLU B 1 171 ? 0.076   -27.774 62.523 1.00 56.62  ? 197 GLU B O   1 
ATOM   4389 C CB  . GLU B 1 171 ? -0.596  -25.089 64.342 1.00 55.44  ? 197 GLU B CB  1 
ATOM   4390 C CG  . GLU B 1 171 ? -0.282  -24.549 65.738 1.00 53.89  ? 197 GLU B CG  1 
ATOM   4391 C CD  . GLU B 1 171 ? -1.441  -24.672 66.730 1.00 62.14  ? 197 GLU B CD  1 
ATOM   4392 O OE1 . GLU B 1 171 ? -2.616  -24.657 66.304 1.00 59.09  ? 197 GLU B OE1 1 
ATOM   4393 O OE2 . GLU B 1 171 ? -1.175  -24.766 67.956 1.00 59.33  ? 197 GLU B OE2 1 
ATOM   4394 N N   . VAL B 1 172 ? 0.070   -25.880 61.272 1.00 58.48  ? 198 VAL B N   1 
ATOM   4395 C CA  . VAL B 1 172 ? -0.255  -26.592 60.029 1.00 57.14  ? 198 VAL B CA  1 
ATOM   4396 C C   . VAL B 1 172 ? 0.855   -27.567 59.661 1.00 53.25  ? 198 VAL B C   1 
ATOM   4397 O O   . VAL B 1 172 ? 0.598   -28.732 59.328 1.00 53.96  ? 198 VAL B O   1 
ATOM   4398 C CB  . VAL B 1 172 ? -0.517  -25.604 58.874 1.00 60.03  ? 198 VAL B CB  1 
ATOM   4399 C CG1 . VAL B 1 172 ? -0.537  -26.354 57.577 1.00 58.51  ? 198 VAL B CG1 1 
ATOM   4400 C CG2 . VAL B 1 172 ? -1.845  -24.900 59.056 1.00 64.88  ? 198 VAL B CG2 1 
ATOM   4401 N N   . VAL B 1 173 ? 2.109   -27.098 59.713 1.00 52.54  ? 199 VAL B N   1 
ATOM   4402 C CA  . VAL B 1 173 ? 3.251   -27.962 59.418 1.00 56.68  ? 199 VAL B CA  1 
ATOM   4403 C C   . VAL B 1 173 ? 3.204   -29.221 60.280 1.00 60.96  ? 199 VAL B C   1 
ATOM   4404 O O   . VAL B 1 173 ? 3.405   -30.340 59.790 1.00 59.67  ? 199 VAL B O   1 
ATOM   4405 C CB  . VAL B 1 173 ? 4.572   -27.200 59.644 1.00 57.51  ? 199 VAL B CB  1 
ATOM   4406 C CG1 . VAL B 1 173 ? 5.747   -28.164 59.542 1.00 56.63  ? 199 VAL B CG1 1 
ATOM   4407 C CG2 . VAL B 1 173 ? 4.731   -26.073 58.663 1.00 58.46  ? 199 VAL B CG2 1 
ATOM   4408 N N   . LEU B 1 174 ? 2.938   -29.057 61.585 1.00 55.55  ? 200 LEU B N   1 
ATOM   4409 C CA  . LEU B 1 174 ? 2.919   -30.223 62.471 1.00 57.06  ? 200 LEU B CA  1 
ATOM   4410 C C   . LEU B 1 174 ? 1.747   -31.130 62.155 1.00 60.07  ? 200 LEU B C   1 
ATOM   4411 O O   . LEU B 1 174 ? 1.898   -32.358 62.108 1.00 56.88  ? 200 LEU B O   1 
ATOM   4412 C CB  . LEU B 1 174 ? 2.846   -29.782 63.935 1.00 58.13  ? 200 LEU B CB  1 
ATOM   4413 C CG  . LEU B 1 174 ? 4.127   -29.141 64.459 1.00 65.93  ? 200 LEU B CG  1 
ATOM   4414 C CD1 . LEU B 1 174 ? 3.840   -28.484 65.770 1.00 62.26  ? 200 LEU B CD1 1 
ATOM   4415 C CD2 . LEU B 1 174 ? 5.243   -30.183 64.603 1.00 59.78  ? 200 LEU B CD2 1 
ATOM   4416 N N   . ALA B 1 175 ? 0.567   -30.541 61.927 1.00 56.77  ? 201 ALA B N   1 
ATOM   4417 C CA  . ALA B 1 175 ? -0.583  -31.356 61.566 1.00 59.93  ? 201 ALA B CA  1 
ATOM   4418 C C   . ALA B 1 175 ? -0.300  -32.163 60.300 1.00 59.19  ? 201 ALA B C   1 
ATOM   4419 O O   . ALA B 1 175 ? -0.619  -33.356 60.239 1.00 59.56  ? 201 ALA B O   1 
ATOM   4420 C CB  . ALA B 1 175 ? -1.828  -30.474 61.416 1.00 54.94  ? 201 ALA B CB  1 
ATOM   4421 N N   . LEU B 1 176 ? 0.345   -31.546 59.293 1.00 59.29  ? 202 LEU B N   1 
ATOM   4422 C CA  . LEU B 1 176 ? 0.661   -32.289 58.068 1.00 62.30  ? 202 LEU B CA  1 
ATOM   4423 C C   . LEU B 1 176 ? 1.667   -33.411 58.318 1.00 63.78  ? 202 LEU B C   1 
ATOM   4424 O O   . LEU B 1 176 ? 1.489   -34.536 57.821 1.00 61.60  ? 202 LEU B O   1 
ATOM   4425 C CB  . LEU B 1 176 ? 1.200   -31.345 56.995 1.00 60.73  ? 202 LEU B CB  1 
ATOM   4426 C CG  . LEU B 1 176 ? 0.128   -30.429 56.435 1.00 57.48  ? 202 LEU B CG  1 
ATOM   4427 C CD1 . LEU B 1 176 ? 0.771   -29.322 55.622 1.00 58.68  ? 202 LEU B CD1 1 
ATOM   4428 C CD2 . LEU B 1 176 ? -0.836  -31.262 55.638 1.00 59.19  ? 202 LEU B CD2 1 
ATOM   4429 N N   . ASP B 1 177 ? 2.715   -33.136 59.107 1.00 62.60  ? 203 ASP B N   1 
ATOM   4430 C CA  . ASP B 1 177 ? 3.679   -34.181 59.440 1.00 65.72  ? 203 ASP B CA  1 
ATOM   4431 C C   . ASP B 1 177 ? 3.016   -35.343 60.170 1.00 67.67  ? 203 ASP B C   1 
ATOM   4432 O O   . ASP B 1 177 ? 3.425   -36.498 59.991 1.00 68.43  ? 203 ASP B O   1 
ATOM   4433 C CB  . ASP B 1 177 ? 4.814   -33.594 60.276 1.00 71.77  ? 203 ASP B CB  1 
ATOM   4434 C CG  . ASP B 1 177 ? 5.970   -34.566 60.457 1.00 75.22  ? 203 ASP B CG  1 
ATOM   4435 O OD1 . ASP B 1 177 ? 6.591   -34.972 59.453 1.00 75.83  ? 203 ASP B OD1 1 
ATOM   4436 O OD2 . ASP B 1 177 ? 6.258   -34.921 61.623 1.00 74.62  ? 203 ASP B OD2 1 
ATOM   4437 N N   . ALA B 1 178 ? 1.997   -35.070 60.998 1.00 60.72  ? 204 ALA B N   1 
ATOM   4438 C CA  . ALA B 1 178 ? 1.252   -36.178 61.602 1.00 65.35  ? 204 ALA B CA  1 
ATOM   4439 C C   . ALA B 1 178 ? 0.487   -36.961 60.543 1.00 68.04  ? 204 ALA B C   1 
ATOM   4440 O O   . ALA B 1 178 ? 0.437   -38.197 60.589 1.00 67.13  ? 204 ALA B O   1 
ATOM   4441 C CB  . ALA B 1 178 ? 0.280   -35.669 62.678 1.00 60.19  ? 204 ALA B CB  1 
ATOM   4442 N N   . ILE B 1 179 ? -0.128  -36.248 59.593 1.00 66.25  ? 205 ILE B N   1 
ATOM   4443 C CA  . ILE B 1 179 ? -0.814  -36.889 58.473 1.00 66.54  ? 205 ILE B CA  1 
ATOM   4444 C C   . ILE B 1 179 ? 0.158   -37.758 57.685 1.00 66.01  ? 205 ILE B C   1 
ATOM   4445 O O   . ILE B 1 179 ? -0.126  -38.924 57.378 1.00 60.99  ? 205 ILE B O   1 
ATOM   4446 C CB  . ILE B 1 179 ? -1.463  -35.822 57.569 1.00 64.48  ? 205 ILE B CB  1 
ATOM   4447 C CG1 . ILE B 1 179 ? -2.639  -35.151 58.289 1.00 73.53  ? 205 ILE B CG1 1 
ATOM   4448 C CG2 . ILE B 1 179 ? -1.880  -36.414 56.278 1.00 66.49  ? 205 ILE B CG2 1 
ATOM   4449 C CD1 . ILE B 1 179 ? -3.709  -36.108 58.756 1.00 72.54  ? 205 ILE B CD1 1 
ATOM   4450 N N   . HIS B 1 180 ? 1.324   -37.198 57.350 1.00 63.15  ? 206 HIS B N   1 
ATOM   4451 C CA  . HIS B 1 180 ? 2.326   -37.965 56.621 1.00 64.98  ? 206 HIS B CA  1 
ATOM   4452 C C   . HIS B 1 180 ? 2.728   -39.220 57.381 1.00 70.68  ? 206 HIS B C   1 
ATOM   4453 O O   . HIS B 1 180 ? 2.845   -40.300 56.790 1.00 71.25  ? 206 HIS B O   1 
ATOM   4454 C CB  . HIS B 1 180 ? 3.549   -37.094 56.341 1.00 65.23  ? 206 HIS B CB  1 
ATOM   4455 C CG  . HIS B 1 180 ? 3.249   -35.920 55.469 1.00 66.25  ? 206 HIS B CG  1 
ATOM   4456 N ND1 . HIS B 1 180 ? 4.074   -34.820 55.389 1.00 67.72  ? 206 HIS B ND1 1 
ATOM   4457 C CD2 . HIS B 1 180 ? 2.190   -35.659 54.665 1.00 64.42  ? 206 HIS B CD2 1 
ATOM   4458 C CE1 . HIS B 1 180 ? 3.549   -33.938 54.555 1.00 63.11  ? 206 HIS B CE1 1 
ATOM   4459 N NE2 . HIS B 1 180 ? 2.405   -34.421 54.104 1.00 67.44  ? 206 HIS B NE2 1 
ATOM   4460 N N   . SER B 1 181 ? 2.926   -39.105 58.700 1.00 69.80  ? 207 SER B N   1 
ATOM   4461 C CA  . SER B 1 181 ? 3.396   -40.251 59.474 1.00 72.01  ? 207 SER B CA  1 
ATOM   4462 C C   . SER B 1 181 ? 2.364   -41.358 59.545 1.00 73.37  ? 207 SER B C   1 
ATOM   4463 O O   . SER B 1 181 ? 2.716   -42.491 59.881 1.00 74.91  ? 207 SER B O   1 
ATOM   4464 C CB  . SER B 1 181 ? 3.796   -39.816 60.884 1.00 69.59  ? 207 SER B CB  1 
ATOM   4465 O OG  . SER B 1 181 ? 4.842   -38.857 60.801 1.00 76.84  ? 207 SER B OG  1 
ATOM   4466 N N   . MET B 1 182 ? 1.105   -41.066 59.239 1.00 71.43  ? 208 MET B N   1 
ATOM   4467 C CA  . MET B 1 182 ? 0.116   -42.115 59.048 1.00 72.37  ? 208 MET B CA  1 
ATOM   4468 C C   . MET B 1 182 ? 0.106   -42.648 57.621 1.00 75.43  ? 208 MET B C   1 
ATOM   4469 O O   . MET B 1 182 ? -0.740  -43.481 57.284 1.00 77.88  ? 208 MET B O   1 
ATOM   4470 C CB  . MET B 1 182 ? -1.262  -41.601 59.453 1.00 73.72  ? 208 MET B CB  1 
ATOM   4471 C CG  . MET B 1 182 ? -1.368  -41.404 60.961 1.00 81.61  ? 208 MET B CG  1 
ATOM   4472 S SD  . MET B 1 182 ? -2.273  -39.941 61.481 1.00 95.95  ? 208 MET B SD  1 
ATOM   4473 C CE  . MET B 1 182 ? -1.777  -39.845 63.213 1.00 78.73  ? 208 MET B CE  1 
ATOM   4474 N N   . GLY B 1 183 ? 1.031   -42.195 56.781 1.00 71.13  ? 209 GLY B N   1 
ATOM   4475 C CA  . GLY B 1 183 ? 1.098   -42.704 55.429 1.00 77.73  ? 209 GLY B CA  1 
ATOM   4476 C C   . GLY B 1 183 ? 0.161   -42.042 54.451 1.00 80.48  ? 209 GLY B C   1 
ATOM   4477 O O   . GLY B 1 183 ? -0.183  -42.645 53.426 1.00 77.31  ? 209 GLY B O   1 
ATOM   4478 N N   . LEU B 1 184 ? -0.258  -40.814 54.724 1.00 77.16  ? 210 LEU B N   1 
ATOM   4479 C CA  . LEU B 1 184 ? -1.227  -40.130 53.893 1.00 70.65  ? 210 LEU B CA  1 
ATOM   4480 C C   . LEU B 1 184 ? -0.634  -38.825 53.398 1.00 74.08  ? 210 LEU B C   1 
ATOM   4481 O O   . LEU B 1 184 ? 0.217   -38.222 54.051 1.00 73.75  ? 210 LEU B O   1 
ATOM   4482 C CB  . LEU B 1 184 ? -2.512  -39.846 54.654 1.00 72.92  ? 210 LEU B CB  1 
ATOM   4483 C CG  . LEU B 1 184 ? -3.276  -41.051 55.195 1.00 77.07  ? 210 LEU B CG  1 
ATOM   4484 C CD1 . LEU B 1 184 ? -4.685  -40.697 55.102 1.00 86.59  ? 210 LEU B CD1 1 
ATOM   4485 C CD2 . LEU B 1 184 ? -3.074  -42.313 54.403 1.00 82.46  ? 210 LEU B CD2 1 
ATOM   4486 N N   . ILE B 1 185 ? -1.024  -38.447 52.186 1.00 75.56  ? 211 ILE B N   1 
ATOM   4487 C CA  . ILE B 1 185 ? -0.727  -37.140 51.627 1.00 68.62  ? 211 ILE B CA  1 
ATOM   4488 C C   . ILE B 1 185 ? -2.047  -36.393 51.470 1.00 72.84  ? 211 ILE B C   1 
ATOM   4489 O O   . ILE B 1 185 ? -3.023  -36.955 50.959 1.00 75.84  ? 211 ILE B O   1 
ATOM   4490 C CB  . ILE B 1 185 ? 0.016   -37.275 50.287 1.00 80.61  ? 211 ILE B CB  1 
ATOM   4491 C CG1 . ILE B 1 185 ? 1.224   -38.195 50.463 1.00 80.15  ? 211 ILE B CG1 1 
ATOM   4492 C CG2 . ILE B 1 185 ? 0.425   -35.908 49.738 1.00 75.61  ? 211 ILE B CG2 1 
ATOM   4493 C CD1 . ILE B 1 185 ? 2.250   -38.037 49.387 1.00 81.29  ? 211 ILE B CD1 1 
ATOM   4494 N N   . HIS B 1 186 ? -2.081  -35.134 51.909 1.00 75.22  ? 212 HIS B N   1 
ATOM   4495 C CA  . HIS B 1 186 ? -3.335  -34.384 51.888 1.00 72.85  ? 212 HIS B CA  1 
ATOM   4496 C C   . HIS B 1 186 ? -3.685  -33.899 50.475 1.00 79.25  ? 212 HIS B C   1 
ATOM   4497 O O   . HIS B 1 186 ? -4.794  -34.150 49.985 1.00 79.35  ? 212 HIS B O   1 
ATOM   4498 C CB  . HIS B 1 186 ? -3.251  -33.221 52.872 1.00 69.72  ? 212 HIS B CB  1 
ATOM   4499 C CG  . HIS B 1 186 ? -4.581  -32.627 53.215 1.00 72.71  ? 212 HIS B CG  1 
ATOM   4500 N ND1 . HIS B 1 186 ? -5.383  -32.013 52.279 1.00 73.94  ? 212 HIS B ND1 1 
ATOM   4501 C CD2 . HIS B 1 186 ? -5.249  -32.549 54.390 1.00 71.40  ? 212 HIS B CD2 1 
ATOM   4502 C CE1 . HIS B 1 186 ? -6.490  -31.586 52.861 1.00 75.16  ? 212 HIS B CE1 1 
ATOM   4503 N NE2 . HIS B 1 186 ? -6.431  -31.893 54.142 1.00 71.55  ? 212 HIS B NE2 1 
ATOM   4504 N N   . ARG B 1 187 ? -2.739  -33.207 49.818 1.00 74.42  ? 213 ARG B N   1 
ATOM   4505 C CA  . ARG B 1 187 ? -2.782  -32.664 48.455 1.00 72.75  ? 213 ARG B CA  1 
ATOM   4506 C C   . ARG B 1 187 ? -3.570  -31.367 48.307 1.00 73.09  ? 213 ARG B C   1 
ATOM   4507 O O   . ARG B 1 187 ? -3.264  -30.578 47.411 1.00 74.98  ? 213 ARG B O   1 
ATOM   4508 C CB  . ARG B 1 187 ? -3.374  -33.664 47.459 1.00 78.24  ? 213 ARG B CB  1 
ATOM   4509 C CG  . ARG B 1 187 ? -2.768  -35.039 47.463 1.00 81.37  ? 213 ARG B CG  1 
ATOM   4510 C CD  . ARG B 1 187 ? -2.972  -35.714 46.121 1.00 82.28  ? 213 ARG B CD  1 
ATOM   4511 N NE  . ARG B 1 187 ? -4.265  -36.388 46.011 1.00 86.36  ? 213 ARG B NE  1 
ATOM   4512 C CZ  . ARG B 1 187 ? -5.187  -36.104 45.091 1.00 88.57  ? 213 ARG B CZ  1 
ATOM   4513 N NH1 . ARG B 1 187 ? -4.964  -35.163 44.179 1.00 85.02  ? 213 ARG B NH1 1 
ATOM   4514 N NH2 . ARG B 1 187 ? -6.338  -36.770 45.074 1.00 88.10  ? 213 ARG B NH2 1 
ATOM   4515 N N   . ASP B 1 188 ? -4.535  -31.091 49.182 1.00 71.53  ? 214 ASP B N   1 
ATOM   4516 C CA  . ASP B 1 188 ? -5.320  -29.864 49.065 1.00 75.13  ? 214 ASP B CA  1 
ATOM   4517 C C   . ASP B 1 188 ? -5.583  -29.218 50.431 1.00 72.06  ? 214 ASP B C   1 
ATOM   4518 O O   . ASP B 1 188 ? -6.712  -28.955 50.827 1.00 68.07  ? 214 ASP B O   1 
ATOM   4519 C CB  . ASP B 1 188 ? -6.621  -30.128 48.304 1.00 76.48  ? 214 ASP B CB  1 
ATOM   4520 C CG  . ASP B 1 188 ? -7.230  -28.848 47.719 1.00 74.22  ? 214 ASP B CG  1 
ATOM   4521 O OD1 . ASP B 1 188 ? -6.582  -27.774 47.785 1.00 68.34  ? 214 ASP B OD1 1 
ATOM   4522 O OD2 . ASP B 1 188 ? -8.348  -28.920 47.162 1.00 79.89  ? 214 ASP B OD2 1 
ATOM   4523 N N   . VAL B 1 189 ? -4.517  -28.939 51.177 1.00 74.15  ? 215 VAL B N   1 
ATOM   4524 C CA  . VAL B 1 189 ? -4.676  -28.221 52.437 1.00 73.83  ? 215 VAL B CA  1 
ATOM   4525 C C   . VAL B 1 189 ? -4.968  -26.760 52.142 1.00 71.22  ? 215 VAL B C   1 
ATOM   4526 O O   . VAL B 1 189 ? -4.303  -26.133 51.308 1.00 69.48  ? 215 VAL B O   1 
ATOM   4527 C CB  . VAL B 1 189 ? -3.426  -28.343 53.319 1.00 68.33  ? 215 VAL B CB  1 
ATOM   4528 C CG1 . VAL B 1 189 ? -3.736  -27.856 54.719 1.00 73.81  ? 215 VAL B CG1 1 
ATOM   4529 C CG2 . VAL B 1 189 ? -2.958  -29.766 53.351 1.00 75.87  ? 215 VAL B CG2 1 
ATOM   4530 N N   . LYS B 1 190 ? -5.949  -26.198 52.836 1.00 66.30  ? 216 LYS B N   1 
ATOM   4531 C CA  . LYS B 1 190 ? -6.310  -24.810 52.608 1.00 66.80  ? 216 LYS B CA  1 
ATOM   4532 C C   . LYS B 1 190 ? -7.058  -24.299 53.827 1.00 62.76  ? 216 LYS B C   1 
ATOM   4533 O O   . LYS B 1 190 ? -7.480  -25.091 54.672 1.00 59.61  ? 216 LYS B O   1 
ATOM   4534 C CB  . LYS B 1 190 ? -7.154  -24.659 51.330 1.00 66.22  ? 216 LYS B CB  1 
ATOM   4535 C CG  . LYS B 1 190 ? -8.297  -25.647 51.146 1.00 70.53  ? 216 LYS B CG  1 
ATOM   4536 C CD  . LYS B 1 190 ? -8.747  -25.637 49.676 1.00 67.83  ? 216 LYS B CD  1 
ATOM   4537 C CE  . LYS B 1 190 ? -9.839  -26.647 49.421 1.00 73.96  ? 216 LYS B CE  1 
ATOM   4538 N NZ  . LYS B 1 190 ? -10.411 -26.437 48.051 1.00 85.92  ? 216 LYS B NZ  1 
ATOM   4539 N N   . PRO B 1 191 ? -7.201  -22.978 53.962 1.00 63.13  ? 217 PRO B N   1 
ATOM   4540 C CA  . PRO B 1 191 ? -7.845  -22.423 55.162 1.00 63.86  ? 217 PRO B CA  1 
ATOM   4541 C C   . PRO B 1 191 ? -9.232  -22.957 55.448 1.00 59.46  ? 217 PRO B C   1 
ATOM   4542 O O   . PRO B 1 191 ? -9.626  -22.950 56.612 1.00 61.23  ? 217 PRO B O   1 
ATOM   4543 C CB  . PRO B 1 191 ? -7.890  -20.918 54.863 1.00 67.58  ? 217 PRO B CB  1 
ATOM   4544 C CG  . PRO B 1 191 ? -7.405  -20.759 53.449 1.00 65.29  ? 217 PRO B CG  1 
ATOM   4545 C CD  . PRO B 1 191 ? -6.543  -21.923 53.176 1.00 64.09  ? 217 PRO B CD  1 
ATOM   4546 N N   . ASP B 1 192 ? -9.984  -23.411 54.437 1.00 63.19  ? 218 ASP B N   1 
ATOM   4547 C CA  . ASP B 1 192 ? -11.268 -24.062 54.698 1.00 63.80  ? 218 ASP B CA  1 
ATOM   4548 C C   . ASP B 1 192 ? -11.095 -25.366 55.471 1.00 61.98  ? 218 ASP B C   1 
ATOM   4549 O O   . ASP B 1 192 ? -11.983 -25.758 56.235 1.00 65.26  ? 218 ASP B O   1 
ATOM   4550 C CB  . ASP B 1 192 ? -11.998 -24.366 53.383 1.00 70.90  ? 218 ASP B CB  1 
ATOM   4551 C CG  . ASP B 1 192 ? -11.882 -23.248 52.374 1.00 78.97  ? 218 ASP B CG  1 
ATOM   4552 O OD1 . ASP B 1 192 ? -10.754 -22.970 51.888 1.00 79.41  ? 218 ASP B OD1 1 
ATOM   4553 O OD2 . ASP B 1 192 ? -12.932 -22.634 52.071 1.00 84.75  ? 218 ASP B OD2 1 
ATOM   4554 N N   . ASN B 1 193 ? -9.957  -26.041 55.299 1.00 63.19  ? 219 ASN B N   1 
ATOM   4555 C CA  . ASN B 1 193 ? -9.681  -27.324 55.945 1.00 64.49  ? 219 ASN B CA  1 
ATOM   4556 C C   . ASN B 1 193 ? -9.127  -27.167 57.336 1.00 57.74  ? 219 ASN B C   1 
ATOM   4557 O O   . ASN B 1 193 ? -8.978  -28.173 58.042 1.00 61.17  ? 219 ASN B O   1 
ATOM   4558 C CB  . ASN B 1 193 ? -8.626  -28.108 55.147 1.00 66.48  ? 219 ASN B CB  1 
ATOM   4559 C CG  . ASN B 1 193 ? -9.095  -28.460 53.797 1.00 67.35  ? 219 ASN B CG  1 
ATOM   4560 O OD1 . ASN B 1 193 ? -10.289 -28.594 53.577 1.00 82.06  ? 219 ASN B OD1 1 
ATOM   4561 N ND2 . ASN B 1 193 ? -8.188  -28.540 52.856 1.00 71.34  ? 219 ASN B ND2 1 
ATOM   4562 N N   . MET B 1 194 ? -8.807  -25.940 57.731 1.00 56.60  ? 220 MET B N   1 
ATOM   4563 C CA  . MET B 1 194 ? -8.129  -25.651 58.984 1.00 58.76  ? 220 MET B CA  1 
ATOM   4564 C C   . MET B 1 194 ? -9.128  -25.068 59.976 1.00 61.17  ? 220 MET B C   1 
ATOM   4565 O O   . MET B 1 194 ? -9.602  -23.943 59.789 1.00 62.56  ? 220 MET B O   1 
ATOM   4566 C CB  . MET B 1 194 ? -6.979  -24.679 58.728 1.00 57.51  ? 220 MET B CB  1 
ATOM   4567 C CG  . MET B 1 194 ? -5.997  -25.134 57.648 1.00 61.35  ? 220 MET B CG  1 
ATOM   4568 S SD  . MET B 1 194 ? -4.839  -23.786 57.276 1.00 65.16  ? 220 MET B SD  1 
ATOM   4569 C CE  . MET B 1 194 ? -3.811  -24.490 55.973 1.00 53.60  ? 220 MET B CE  1 
ATOM   4570 N N   . LEU B 1 195 ? -9.418  -25.807 61.044 1.00 56.49  ? 221 LEU B N   1 
ATOM   4571 C CA  . LEU B 1 195 ? -10.393 -25.391 62.044 1.00 60.41  ? 221 LEU B CA  1 
ATOM   4572 C C   . LEU B 1 195 ? -9.706  -25.114 63.376 1.00 57.94  ? 221 LEU B C   1 
ATOM   4573 O O   . LEU B 1 195 ? -8.629  -25.650 63.669 1.00 60.81  ? 221 LEU B O   1 
ATOM   4574 C CB  . LEU B 1 195 ? -11.482 -26.454 62.228 1.00 53.34  ? 221 LEU B CB  1 
ATOM   4575 C CG  . LEU B 1 195 ? -12.282 -26.774 60.961 1.00 62.23  ? 221 LEU B CG  1 
ATOM   4576 C CD1 . LEU B 1 195 ? -13.171 -27.965 61.198 1.00 64.69  ? 221 LEU B CD1 1 
ATOM   4577 C CD2 . LEU B 1 195 ? -13.139 -25.605 60.556 1.00 61.62  ? 221 LEU B CD2 1 
ATOM   4578 N N   . LEU B 1 196 ? -10.335 -24.269 64.183 1.00 59.10  ? 222 LEU B N   1 
ATOM   4579 C CA  . LEU B 1 196 ? -9.815  -23.866 65.489 1.00 60.95  ? 222 LEU B CA  1 
ATOM   4580 C C   . LEU B 1 196 ? -10.731 -24.366 66.599 1.00 61.99  ? 222 LEU B C   1 
ATOM   4581 O O   . LEU B 1 196 ? -11.960 -24.223 66.509 1.00 55.31  ? 222 LEU B O   1 
ATOM   4582 C CB  . LEU B 1 196 ? -9.688  -22.347 65.572 1.00 61.24  ? 222 LEU B CB  1 
ATOM   4583 C CG  . LEU B 1 196 ? -8.827  -21.758 64.469 1.00 56.81  ? 222 LEU B CG  1 
ATOM   4584 C CD1 . LEU B 1 196 ? -8.907  -20.254 64.529 1.00 59.57  ? 222 LEU B CD1 1 
ATOM   4585 C CD2 . LEU B 1 196 ? -7.367  -22.258 64.622 1.00 53.76  ? 222 LEU B CD2 1 
ATOM   4586 N N   . ASP B 1 197 ? -10.136 -24.932 67.652 1.00 59.92  ? 223 ASP B N   1 
ATOM   4587 C CA  . ASP B 1 197 ? -10.927 -25.501 68.736 1.00 60.60  ? 223 ASP B CA  1 
ATOM   4588 C C   . ASP B 1 197 ? -11.332 -24.394 69.725 1.00 65.92  ? 223 ASP B C   1 
ATOM   4589 O O   . ASP B 1 197 ? -11.075 -23.205 69.506 1.00 64.78  ? 223 ASP B O   1 
ATOM   4590 C CB  . ASP B 1 197 ? -10.167 -26.665 69.385 1.00 58.26  ? 223 ASP B CB  1 
ATOM   4591 C CG  . ASP B 1 197 ? -8.801  -26.260 69.951 1.00 66.36  ? 223 ASP B CG  1 
ATOM   4592 O OD1 . ASP B 1 197 ? -8.624  -25.088 70.347 1.00 61.18  ? 223 ASP B OD1 1 
ATOM   4593 O OD2 . ASP B 1 197 ? -7.887  -27.123 69.975 1.00 67.07  ? 223 ASP B OD2 1 
ATOM   4594 N N   . LYS B 1 198 ? -11.968 -24.784 70.840 1.00 68.02  ? 224 LYS B N   1 
ATOM   4595 C CA  . LYS B 1 198 ? -12.397 -23.822 71.855 1.00 67.69  ? 224 LYS B CA  1 
ATOM   4596 C C   . LYS B 1 198 ? -11.243 -22.972 72.378 1.00 67.89  ? 224 LYS B C   1 
ATOM   4597 O O   . LYS B 1 198 ? -11.475 -21.856 72.853 1.00 65.42  ? 224 LYS B O   1 
ATOM   4598 C CB  . LYS B 1 198 ? -13.048 -24.556 73.030 1.00 63.20  ? 224 LYS B CB  1 
ATOM   4599 N N   . HIS B 1 199 ? -10.011 -23.468 72.286 1.00 66.24  ? 225 HIS B N   1 
ATOM   4600 C CA  . HIS B 1 199 ? -8.830  -22.763 72.762 1.00 63.64  ? 225 HIS B CA  1 
ATOM   4601 C C   . HIS B 1 199 ? -8.067  -22.032 71.663 1.00 66.38  ? 225 HIS B C   1 
ATOM   4602 O O   . HIS B 1 199 ? -7.002  -21.463 71.943 1.00 66.59  ? 225 HIS B O   1 
ATOM   4603 C CB  . HIS B 1 199 ? -7.900  -23.755 73.457 1.00 59.90  ? 225 HIS B CB  1 
ATOM   4604 C CG  . HIS B 1 199 ? -8.565  -24.517 74.561 1.00 71.43  ? 225 HIS B CG  1 
ATOM   4605 N ND1 . HIS B 1 199 ? -9.051  -23.907 75.701 1.00 69.66  ? 225 HIS B ND1 1 
ATOM   4606 C CD2 . HIS B 1 199 ? -8.856  -25.834 74.687 1.00 68.81  ? 225 HIS B CD2 1 
ATOM   4607 C CE1 . HIS B 1 199 ? -9.596  -24.818 76.487 1.00 68.53  ? 225 HIS B CE1 1 
ATOM   4608 N NE2 . HIS B 1 199 ? -9.491  -25.996 75.896 1.00 73.51  ? 225 HIS B NE2 1 
ATOM   4609 N N   . GLY B 1 200 ? -8.562  -22.044 70.422 1.00 65.28  ? 226 GLY B N   1 
ATOM   4610 C CA  . GLY B 1 200 ? -7.870  -21.374 69.340 1.00 62.47  ? 226 GLY B CA  1 
ATOM   4611 C C   . GLY B 1 200 ? -6.749  -22.162 68.699 1.00 61.22  ? 226 GLY B C   1 
ATOM   4612 O O   . GLY B 1 200 ? -5.969  -21.588 67.924 1.00 59.44  ? 226 GLY B O   1 
ATOM   4613 N N   . HIS B 1 201 ? -6.643  -23.456 68.984 1.00 60.92  ? 227 HIS B N   1 
ATOM   4614 C CA  . HIS B 1 201 ? -5.632  -24.308 68.374 1.00 62.05  ? 227 HIS B CA  1 
ATOM   4615 C C   . HIS B 1 201 ? -6.202  -25.086 67.194 1.00 57.67  ? 227 HIS B C   1 
ATOM   4616 O O   . HIS B 1 201 ? -7.392  -25.401 67.141 1.00 58.01  ? 227 HIS B O   1 
ATOM   4617 C CB  . HIS B 1 201 ? -5.053  -25.260 69.418 1.00 59.04  ? 227 HIS B CB  1 
ATOM   4618 C CG  . HIS B 1 201 ? -4.101  -24.588 70.346 1.00 61.49  ? 227 HIS B CG  1 
ATOM   4619 N ND1 . HIS B 1 201 ? -2.779  -24.372 70.019 1.00 59.44  ? 227 HIS B ND1 1 
ATOM   4620 C CD2 . HIS B 1 201 ? -4.287  -24.034 71.569 1.00 56.78  ? 227 HIS B CD2 1 
ATOM   4621 C CE1 . HIS B 1 201 ? -2.181  -23.744 71.017 1.00 58.12  ? 227 HIS B CE1 1 
ATOM   4622 N NE2 . HIS B 1 201 ? -3.076  -23.520 71.965 1.00 59.93  ? 227 HIS B NE2 1 
ATOM   4623 N N   . LEU B 1 202 ? -5.313  -25.461 66.285 1.00 54.30  ? 228 LEU B N   1 
ATOM   4624 C CA  . LEU B 1 202 ? -5.707  -25.923 64.959 1.00 57.48  ? 228 LEU B CA  1 
ATOM   4625 C C   . LEU B 1 202 ? -6.026  -27.411 64.939 1.00 60.48  ? 228 LEU B C   1 
ATOM   4626 O O   . LEU B 1 202 ? -5.364  -28.211 65.605 1.00 58.77  ? 228 LEU B O   1 
ATOM   4627 C CB  . LEU B 1 202 ? -4.581  -25.649 63.962 1.00 56.60  ? 228 LEU B CB  1 
ATOM   4628 C CG  . LEU B 1 202 ? -4.710  -26.378 62.615 1.00 59.49  ? 228 LEU B CG  1 
ATOM   4629 C CD1 . LEU B 1 202 ? -5.810  -25.717 61.825 1.00 63.24  ? 228 LEU B CD1 1 
ATOM   4630 C CD2 . LEU B 1 202 ? -3.421  -26.376 61.848 1.00 58.60  ? 228 LEU B CD2 1 
ATOM   4631 N N   . LYS B 1 203 ? -7.030  -27.787 64.146 1.00 57.50  ? 229 LYS B N   1 
ATOM   4632 C CA  . LYS B 1 203 ? -7.150  -29.171 63.704 1.00 58.42  ? 229 LYS B CA  1 
ATOM   4633 C C   . LYS B 1 203 ? -7.555  -29.168 62.240 1.00 57.22  ? 229 LYS B C   1 
ATOM   4634 O O   . LYS B 1 203 ? -8.313  -28.302 61.805 1.00 55.37  ? 229 LYS B O   1 
ATOM   4635 C CB  . LYS B 1 203 ? -8.172  -29.981 64.524 1.00 59.91  ? 229 LYS B CB  1 
ATOM   4636 C CG  . LYS B 1 203 ? -7.854  -30.159 66.016 1.00 59.69  ? 229 LYS B CG  1 
ATOM   4637 C CD  . LYS B 1 203 ? -8.955  -30.983 66.714 1.00 55.50  ? 229 LYS B CD  1 
ATOM   4638 C CE  . LYS B 1 203 ? -8.914  -30.780 68.232 1.00 59.77  ? 229 LYS B CE  1 
ATOM   4639 N NZ  . LYS B 1 203 ? -7.850  -31.563 68.894 1.00 51.18  ? 229 LYS B NZ  1 
ATOM   4640 N N   . LEU B 1 204 ? -7.096  -30.181 61.509 1.00 58.90  ? 230 LEU B N   1 
ATOM   4641 C CA  . LEU B 1 204 ? -7.437  -30.380 60.108 1.00 55.62  ? 230 LEU B CA  1 
ATOM   4642 C C   . LEU B 1 204 ? -8.706  -31.216 59.981 1.00 62.25  ? 230 LEU B C   1 
ATOM   4643 O O   . LEU B 1 204 ? -8.968  -32.111 60.796 1.00 62.07  ? 230 LEU B O   1 
ATOM   4644 C CB  . LEU B 1 204 ? -6.292  -31.078 59.375 1.00 52.50  ? 230 LEU B CB  1 
ATOM   4645 C CG  . LEU B 1 204 ? -4.997  -30.271 59.363 1.00 58.53  ? 230 LEU B CG  1 
ATOM   4646 C CD1 . LEU B 1 204 ? -3.982  -30.908 58.412 1.00 63.94  ? 230 LEU B CD1 1 
ATOM   4647 C CD2 . LEU B 1 204 ? -5.288  -28.822 58.985 1.00 59.85  ? 230 LEU B CD2 1 
ATOM   4648 N N   . ALA B 1 205 ? -9.495  -30.931 58.939 1.00 63.03  ? 231 ALA B N   1 
ATOM   4649 C CA  . ALA B 1 205 ? -10.814 -31.564 58.948 1.00 64.40  ? 231 ALA B CA  1 
ATOM   4650 C C   . ALA B 1 205 ? -11.211 -32.274 57.663 1.00 73.77  ? 231 ALA B C   1 
ATOM   4651 O O   . ALA B 1 205 ? -11.916 -33.290 57.734 1.00 84.15  ? 231 ALA B O   1 
ATOM   4652 C CB  . ALA B 1 205 ? -11.893 -30.545 59.278 1.00 62.29  ? 231 ALA B CB  1 
ATOM   4653 N N   . ASP B 1 206 ? -10.829 -31.768 56.497 1.00 68.30  ? 232 ASP B N   1 
ATOM   4654 C CA  . ASP B 1 206 ? -11.427 -32.248 55.243 1.00 73.47  ? 232 ASP B CA  1 
ATOM   4655 C C   . ASP B 1 206 ? -10.392 -33.078 54.504 1.00 72.47  ? 232 ASP B C   1 
ATOM   4656 O O   . ASP B 1 206 ? -9.424  -32.546 53.949 1.00 75.97  ? 232 ASP B O   1 
ATOM   4657 C CB  . ASP B 1 206 ? -11.946 -31.081 54.400 1.00 77.48  ? 232 ASP B CB  1 
ATOM   4658 C CG  . ASP B 1 206 ? -12.645 -31.511 53.084 1.00 75.81  ? 232 ASP B CG  1 
ATOM   4659 O OD1 . ASP B 1 206 ? -12.726 -32.708 52.714 1.00 77.40  ? 232 ASP B OD1 1 
ATOM   4660 O OD2 . ASP B 1 206 ? -13.176 -30.596 52.431 1.00 74.71  ? 232 ASP B OD2 1 
ATOM   4661 N N   . PHE B 1 207 ? -10.564 -34.381 54.539 1.00 70.92  ? 233 PHE B N   1 
ATOM   4662 C CA  . PHE B 1 207 ? -9.605  -35.274 53.916 1.00 74.79  ? 233 PHE B CA  1 
ATOM   4663 C C   . PHE B 1 207 ? -10.148 -35.878 52.621 1.00 74.95  ? 233 PHE B C   1 
ATOM   4664 O O   . PHE B 1 207 ? -9.777  -36.989 52.242 1.00 77.35  ? 233 PHE B O   1 
ATOM   4665 C CB  . PHE B 1 207 ? -9.182  -36.329 54.931 1.00 70.37  ? 233 PHE B CB  1 
ATOM   4666 C CG  . PHE B 1 207 ? -8.706  -35.725 56.229 1.00 77.70  ? 233 PHE B CG  1 
ATOM   4667 C CD1 . PHE B 1 207 ? -7.427  -35.201 56.340 1.00 73.68  ? 233 PHE B CD1 1 
ATOM   4668 C CD2 . PHE B 1 207 ? -9.558  -35.626 57.318 1.00 75.78  ? 233 PHE B CD2 1 
ATOM   4669 C CE1 . PHE B 1 207 ? -6.990  -34.630 57.520 1.00 72.69  ? 233 PHE B CE1 1 
ATOM   4670 C CE2 . PHE B 1 207 ? -9.126  -35.061 58.510 1.00 70.60  ? 233 PHE B CE2 1 
ATOM   4671 C CZ  . PHE B 1 207 ? -7.848  -34.556 58.610 1.00 69.78  ? 233 PHE B CZ  1 
ATOM   4672 N N   . GLY B 1 208 ? -11.031 -35.145 51.933 1.00 74.38  ? 234 GLY B N   1 
ATOM   4673 C CA  . GLY B 1 208 ? -11.597 -35.654 50.694 1.00 80.27  ? 234 GLY B CA  1 
ATOM   4674 C C   . GLY B 1 208 ? -10.546 -35.902 49.625 1.00 80.77  ? 234 GLY B C   1 
ATOM   4675 O O   . GLY B 1 208 ? -10.706 -36.793 48.790 1.00 80.69  ? 234 GLY B O   1 
ATOM   4676 N N   . THR B 1 209 ? -9.445  -35.149 49.659 1.00 84.77  ? 235 THR B N   1 
ATOM   4677 C CA  . THR B 1 209 ? -8.377  -35.293 48.681 1.00 76.07  ? 235 THR B CA  1 
ATOM   4678 C C   . THR B 1 209 ? -7.328  -36.317 49.102 1.00 82.94  ? 235 THR B C   1 
ATOM   4679 O O   . THR B 1 209 ? -6.459  -36.650 48.285 1.00 76.57  ? 235 THR B O   1 
ATOM   4680 C CB  . THR B 1 209 ? -7.702  -33.929 48.417 1.00 78.01  ? 235 THR B CB  1 
ATOM   4681 O OG1 . THR B 1 209 ? -7.467  -33.222 49.647 1.00 78.82  ? 235 THR B OG1 1 
ATOM   4682 C CG2 . THR B 1 209 ? -8.583  -33.067 47.541 1.00 76.68  ? 235 THR B CG2 1 
ATOM   4683 N N   . CYS B 1 210 ? -7.401  -36.847 50.332 1.00 80.28  ? 236 CYS B N   1 
ATOM   4684 C CA  . CYS B 1 210 ? -6.285  -37.615 50.881 1.00 78.84  ? 236 CYS B CA  1 
ATOM   4685 C C   . CYS B 1 210 ? -6.156  -38.985 50.228 1.00 81.20  ? 236 CYS B C   1 
ATOM   4686 O O   . CYS B 1 210 ? -7.153  -39.690 50.034 1.00 77.25  ? 236 CYS B O   1 
ATOM   4687 C CB  . CYS B 1 210 ? -6.460  -37.824 52.390 1.00 78.82  ? 236 CYS B CB  1 
ATOM   4688 S SG  . CYS B 1 210 ? -6.129  -36.390 53.380 1.00 82.66  ? 236 CYS B SG  1 
ATOM   4689 N N   . MET B 1 211 ? -4.900  -39.390 49.985 1.00 80.86  ? 237 MET B N   1 
ATOM   4690 C CA  . MET B 1 211 ? -4.539  -40.654 49.346 1.00 83.43  ? 237 MET B CA  1 
ATOM   4691 C C   . MET B 1 211 ? -3.414  -41.342 50.124 1.00 84.71  ? 237 MET B C   1 
ATOM   4692 O O   . MET B 1 211 ? -2.511  -40.678 50.647 1.00 80.16  ? 237 MET B O   1 
ATOM   4693 C CB  . MET B 1 211 ? -4.098  -40.453 47.873 1.00 85.61  ? 237 MET B CB  1 
ATOM   4694 C CG  . MET B 1 211 ? -4.931  -39.437 47.046 1.00 93.15  ? 237 MET B CG  1 
ATOM   4695 S SD  . MET B 1 211 ? -6.459  -40.075 46.269 1.00 108.35 ? 237 MET B SD  1 
ATOM   4696 C CE  . MET B 1 211 ? -6.035  -40.086 44.523 1.00 99.55  ? 237 MET B CE  1 
ATOM   4697 N N   . LYS B 1 212 ? -3.481  -42.674 50.221 1.00 80.59  ? 238 LYS B N   1 
ATOM   4698 C CA  . LYS B 1 212 ? -2.433  -43.428 50.903 1.00 78.85  ? 238 LYS B CA  1 
ATOM   4699 C C   . LYS B 1 212 ? -1.156  -43.456 50.063 1.00 81.21  ? 238 LYS B C   1 
ATOM   4700 O O   . LYS B 1 212 ? -1.207  -43.537 48.834 1.00 88.59  ? 238 LYS B O   1 
ATOM   4701 C CB  . LYS B 1 212 ? -2.907  -44.851 51.189 1.00 75.59  ? 238 LYS B CB  1 
ATOM   4702 N N   . MET B 1 213 ? -0.003  -43.368 50.729 1.00 81.31  ? 239 MET B N   1 
ATOM   4703 C CA  . MET B 1 213 ? 1.295   -43.290 50.044 1.00 83.31  ? 239 MET B CA  1 
ATOM   4704 C C   . MET B 1 213 ? 1.787   -44.678 49.648 1.00 83.74  ? 239 MET B C   1 
ATOM   4705 O O   . MET B 1 213 ? 1.130   -45.679 49.933 1.00 80.76  ? 239 MET B O   1 
ATOM   4706 C CB  . MET B 1 213 ? 2.337   -42.586 50.928 1.00 78.10  ? 239 MET B CB  1 
ATOM   4707 N N   . ALA B 1 224 ? -9.779  -37.151 42.019 1.00 94.32  ? 250 ALA B N   1 
ATOM   4708 C CA  . ALA B 1 224 ? -10.581 -35.949 41.797 1.00 95.68  ? 250 ALA B CA  1 
ATOM   4709 C C   . ALA B 1 224 ? -10.092 -34.867 42.743 1.00 93.53  ? 250 ALA B C   1 
ATOM   4710 O O   . ALA B 1 224 ? -9.847  -35.158 43.910 1.00 92.09  ? 250 ALA B O   1 
ATOM   4711 C CB  . ALA B 1 224 ? -12.060 -36.235 42.014 1.00 102.29 ? 250 ALA B CB  1 
ATOM   4712 N N   . VAL B 1 225 ? -9.929  -33.626 42.274 1.00 88.90  ? 251 VAL B N   1 
ATOM   4713 C CA  . VAL B 1 225 ? -9.309  -32.656 43.171 1.00 88.26  ? 251 VAL B CA  1 
ATOM   4714 C C   . VAL B 1 225 ? -10.030 -31.308 43.298 1.00 89.38  ? 251 VAL B C   1 
ATOM   4715 O O   . VAL B 1 225 ? -10.149 -30.783 44.413 1.00 94.70  ? 251 VAL B O   1 
ATOM   4716 C CB  . VAL B 1 225 ? -7.832  -32.462 42.779 1.00 86.32  ? 251 VAL B CB  1 
ATOM   4717 C CG1 . VAL B 1 225 ? -7.653  -31.419 41.672 1.00 82.44  ? 251 VAL B CG1 1 
ATOM   4718 C CG2 . VAL B 1 225 ? -7.013  -32.141 44.021 1.00 85.41  ? 251 VAL B CG2 1 
ATOM   4719 N N   . GLY B 1 226 ? -10.513 -30.720 42.201 1.00 86.01  ? 252 GLY B N   1 
ATOM   4720 C CA  . GLY B 1 226 ? -11.286 -29.498 42.369 1.00 79.98  ? 252 GLY B CA  1 
ATOM   4721 C C   . GLY B 1 226 ? -10.575 -28.191 42.056 1.00 75.47  ? 252 GLY B C   1 
ATOM   4722 O O   . GLY B 1 226 ? -9.776  -28.128 41.117 1.00 75.77  ? 252 GLY B O   1 
ATOM   4723 N N   . THR B 1 227 ? -10.866 -27.128 42.831 1.00 67.63  ? 253 THR B N   1 
ATOM   4724 C CA  . THR B 1 227 ? -10.315 -25.798 42.552 1.00 70.26  ? 253 THR B CA  1 
ATOM   4725 C C   . THR B 1 227 ? -8.839  -25.745 42.964 1.00 67.33  ? 253 THR B C   1 
ATOM   4726 O O   . THR B 1 227 ? -8.491  -26.188 44.058 1.00 63.56  ? 253 THR B O   1 
ATOM   4727 C CB  . THR B 1 227 ? -11.114 -24.721 43.293 1.00 73.29  ? 253 THR B CB  1 
ATOM   4728 O OG1 . THR B 1 227 ? -10.676 -24.644 44.654 1.00 74.83  ? 253 THR B OG1 1 
ATOM   4729 C CG2 . THR B 1 227 ? -12.611 -25.042 43.273 1.00 76.59  ? 253 THR B CG2 1 
ATOM   4730 N N   . PRO B 1 228 ? -7.959  -25.218 42.113 1.00 67.43  ? 254 PRO B N   1 
ATOM   4731 C CA  . PRO B 1 228 ? -6.511  -25.448 42.248 1.00 62.81  ? 254 PRO B CA  1 
ATOM   4732 C C   . PRO B 1 228 ? -5.725  -24.407 43.024 1.00 59.85  ? 254 PRO B C   1 
ATOM   4733 O O   . PRO B 1 228 ? -4.497  -24.533 43.065 1.00 59.67  ? 254 PRO B O   1 
ATOM   4734 C CB  . PRO B 1 228 ? -6.056  -25.441 40.785 1.00 63.74  ? 254 PRO B CB  1 
ATOM   4735 C CG  . PRO B 1 228 ? -6.960  -24.394 40.139 1.00 67.13  ? 254 PRO B CG  1 
ATOM   4736 C CD  . PRO B 1 228 ? -8.285  -24.461 40.885 1.00 64.91  ? 254 PRO B CD  1 
ATOM   4737 N N   . ASP B 1 229 ? -6.371  -23.421 43.654 1.00 59.89  ? 255 ASP B N   1 
ATOM   4738 C CA  . ASP B 1 229 ? -5.638  -22.273 44.195 1.00 65.01  ? 255 ASP B CA  1 
ATOM   4739 C C   . ASP B 1 229 ? -4.490  -22.644 45.133 1.00 62.41  ? 255 ASP B C   1 
ATOM   4740 O O   . ASP B 1 229 ? -3.475  -21.933 45.166 1.00 62.22  ? 255 ASP B O   1 
ATOM   4741 C CB  . ASP B 1 229 ? -6.606  -21.363 44.945 1.00 66.21  ? 255 ASP B CB  1 
ATOM   4742 C CG  . ASP B 1 229 ? -7.580  -20.677 44.015 1.00 70.99  ? 255 ASP B CG  1 
ATOM   4743 O OD1 . ASP B 1 229 ? -8.195  -21.391 43.190 1.00 65.73  ? 255 ASP B OD1 1 
ATOM   4744 O OD2 . ASP B 1 229 ? -7.719  -19.438 44.113 1.00 71.86  ? 255 ASP B OD2 1 
ATOM   4745 N N   . TYR B 1 230 ? -4.610  -23.748 45.878 1.00 61.56  ? 256 TYR B N   1 
ATOM   4746 C CA  . TYR B 1 230 ? -3.614  -24.134 46.874 1.00 61.36  ? 256 TYR B CA  1 
ATOM   4747 C C   . TYR B 1 230 ? -2.834  -25.378 46.469 1.00 66.22  ? 256 TYR B C   1 
ATOM   4748 O O   . TYR B 1 230 ? -1.898  -25.765 47.178 1.00 64.01  ? 256 TYR B O   1 
ATOM   4749 C CB  . TYR B 1 230 ? -4.281  -24.365 48.241 1.00 60.81  ? 256 TYR B CB  1 
ATOM   4750 C CG  . TYR B 1 230 ? -4.909  -23.121 48.813 1.00 58.19  ? 256 TYR B CG  1 
ATOM   4751 C CD1 . TYR B 1 230 ? -6.183  -22.736 48.421 1.00 62.37  ? 256 TYR B CD1 1 
ATOM   4752 C CD2 . TYR B 1 230 ? -4.225  -22.314 49.719 1.00 60.82  ? 256 TYR B CD2 1 
ATOM   4753 C CE1 . TYR B 1 230 ? -6.775  -21.593 48.922 1.00 65.37  ? 256 TYR B CE1 1 
ATOM   4754 C CE2 . TYR B 1 230 ? -4.809  -21.145 50.224 1.00 63.94  ? 256 TYR B CE2 1 
ATOM   4755 C CZ  . TYR B 1 230 ? -6.090  -20.793 49.811 1.00 62.61  ? 256 TYR B CZ  1 
ATOM   4756 O OH  . TYR B 1 230 ? -6.731  -19.659 50.273 1.00 63.66  ? 256 TYR B OH  1 
ATOM   4757 N N   . ILE B 1 231 ? -3.197  -26.006 45.347 1.00 61.31  ? 257 ILE B N   1 
ATOM   4758 C CA  . ILE B 1 231 ? -2.598  -27.250 44.875 1.00 62.97  ? 257 ILE B CA  1 
ATOM   4759 C C   . ILE B 1 231 ? -1.302  -26.969 44.114 1.00 65.61  ? 257 ILE B C   1 
ATOM   4760 O O   . ILE B 1 231 ? -1.146  -25.930 43.457 1.00 61.55  ? 257 ILE B O   1 
ATOM   4761 C CB  . ILE B 1 231 ? -3.637  -28.010 44.029 1.00 65.13  ? 257 ILE B CB  1 
ATOM   4762 C CG1 . ILE B 1 231 ? -4.874  -28.274 44.899 1.00 64.33  ? 257 ILE B CG1 1 
ATOM   4763 C CG2 . ILE B 1 231 ? -3.080  -29.308 43.509 1.00 63.37  ? 257 ILE B CG2 1 
ATOM   4764 C CD1 . ILE B 1 231 ? -6.074  -28.777 44.158 1.00 68.71  ? 257 ILE B CD1 1 
ATOM   4765 N N   . SER B 1 232 ? -0.348  -27.907 44.210 1.00 66.59  ? 258 SER B N   1 
ATOM   4766 C CA  . SER B 1 232 ? 0.988   -27.724 43.661 1.00 66.78  ? 258 SER B CA  1 
ATOM   4767 C C   . SER B 1 232 ? 1.036   -28.090 42.182 1.00 65.67  ? 258 SER B C   1 
ATOM   4768 O O   . SER B 1 232 ? 0.171   -28.821 41.691 1.00 63.20  ? 258 SER B O   1 
ATOM   4769 C CB  . SER B 1 232 ? 1.984   -28.592 44.427 1.00 62.50  ? 258 SER B CB  1 
ATOM   4770 O OG  . SER B 1 232 ? 1.654   -29.961 44.284 1.00 58.03  ? 258 SER B OG  1 
ATOM   4771 N N   . PRO B 1 233 ? 2.054   -27.592 41.453 1.00 64.02  ? 259 PRO B N   1 
ATOM   4772 C CA  . PRO B 1 233 ? 2.185   -27.935 40.027 1.00 67.98  ? 259 PRO B CA  1 
ATOM   4773 C C   . PRO B 1 233 ? 2.193   -29.427 39.770 1.00 67.95  ? 259 PRO B C   1 
ATOM   4774 O O   . PRO B 1 233 ? 1.603   -29.888 38.786 1.00 65.40  ? 259 PRO B O   1 
ATOM   4775 C CB  . PRO B 1 233 ? 3.532   -27.304 39.643 1.00 64.42  ? 259 PRO B CB  1 
ATOM   4776 C CG  . PRO B 1 233 ? 3.690   -26.173 40.562 1.00 63.28  ? 259 PRO B CG  1 
ATOM   4777 C CD  . PRO B 1 233 ? 3.029   -26.558 41.858 1.00 68.36  ? 259 PRO B CD  1 
ATOM   4778 N N   . GLU B 1 234 ? 2.868   -30.194 40.629 1.00 65.78  ? 260 GLU B N   1 
ATOM   4779 C CA  . GLU B 1 234 ? 3.024   -31.620 40.372 1.00 63.96  ? 260 GLU B CA  1 
ATOM   4780 C C   . GLU B 1 234 ? 1.719   -32.371 40.579 1.00 65.21  ? 260 GLU B C   1 
ATOM   4781 O O   . GLU B 1 234 ? 1.453   -33.354 39.879 1.00 65.18  ? 260 GLU B O   1 
ATOM   4782 C CB  . GLU B 1 234 ? 4.143   -32.199 41.246 1.00 68.67  ? 260 GLU B CB  1 
ATOM   4783 C CG  . GLU B 1 234 ? 3.867   -32.199 42.756 1.00 66.67  ? 260 GLU B CG  1 
ATOM   4784 C CD  . GLU B 1 234 ? 4.562   -31.056 43.519 1.00 69.07  ? 260 GLU B CD  1 
ATOM   4785 O OE1 . GLU B 1 234 ? 4.805   -29.993 42.916 1.00 65.12  ? 260 GLU B OE1 1 
ATOM   4786 O OE2 . GLU B 1 234 ? 4.840   -31.213 44.744 1.00 73.97  ? 260 GLU B OE2 1 
ATOM   4787 N N   . VAL B 1 235 ? 0.884   -31.931 41.519 1.00 62.91  ? 261 VAL B N   1 
ATOM   4788 C CA  . VAL B 1 235 ? -0.408  -32.590 41.671 1.00 65.44  ? 261 VAL B CA  1 
ATOM   4789 C C   . VAL B 1 235 ? -1.328  -32.205 40.519 1.00 62.59  ? 261 VAL B C   1 
ATOM   4790 O O   . VAL B 1 235 ? -2.029  -33.059 39.959 1.00 61.34  ? 261 VAL B O   1 
ATOM   4791 C CB  . VAL B 1 235 ? -1.039  -32.263 43.039 1.00 65.48  ? 261 VAL B CB  1 
ATOM   4792 C CG1 . VAL B 1 235 ? -2.476  -32.809 43.110 1.00 61.44  ? 261 VAL B CG1 1 
ATOM   4793 C CG2 . VAL B 1 235 ? -0.201  -32.846 44.159 1.00 63.20  ? 261 VAL B CG2 1 
ATOM   4794 N N   . LEU B 1 236 ? -1.289  -30.936 40.103 1.00 60.14  ? 262 LEU B N   1 
ATOM   4795 C CA  . LEU B 1 236 ? -2.086  -30.515 38.954 1.00 66.12  ? 262 LEU B CA  1 
ATOM   4796 C C   . LEU B 1 236 ? -1.764  -31.373 37.735 1.00 67.95  ? 262 LEU B C   1 
ATOM   4797 O O   . LEU B 1 236 ? -2.675  -31.882 37.073 1.00 61.37  ? 262 LEU B O   1 
ATOM   4798 C CB  . LEU B 1 236 ? -1.880  -29.022 38.671 1.00 55.96  ? 262 LEU B CB  1 
ATOM   4799 C CG  . LEU B 1 236 ? -2.484  -28.124 39.767 1.00 65.36  ? 262 LEU B CG  1 
ATOM   4800 C CD1 . LEU B 1 236 ? -2.302  -26.647 39.460 1.00 66.80  ? 262 LEU B CD1 1 
ATOM   4801 C CD2 . LEU B 1 236 ? -3.967  -28.452 40.014 1.00 58.28  ? 262 LEU B CD2 1 
ATOM   4802 N N   . LYS B 1 237 ? -0.467  -31.602 37.462 1.00 67.02  ? 263 LYS B N   1 
ATOM   4803 C CA  . LYS B 1 237 ? -0.092  -32.397 36.290 1.00 70.54  ? 263 LYS B CA  1 
ATOM   4804 C C   . LYS B 1 237 ? -0.499  -33.870 36.409 1.00 69.46  ? 263 LYS B C   1 
ATOM   4805 O O   . LYS B 1 237 ? -0.817  -34.492 35.385 1.00 72.80  ? 263 LYS B O   1 
ATOM   4806 C CB  . LYS B 1 237 ? 1.414   -32.262 36.025 1.00 70.19  ? 263 LYS B CB  1 
ATOM   4807 C CG  . LYS B 1 237 ? 1.835   -30.846 35.679 1.00 68.68  ? 263 LYS B CG  1 
ATOM   4808 C CD  . LYS B 1 237 ? 2.984   -30.788 34.700 1.00 81.51  ? 263 LYS B CD  1 
ATOM   4809 C CE  . LYS B 1 237 ? 4.273   -31.340 35.281 1.00 80.73  ? 263 LYS B CE  1 
ATOM   4810 N NZ  . LYS B 1 237 ? 5.291   -31.571 34.204 1.00 83.70  ? 263 LYS B NZ  1 
ATOM   4811 N N   . SER B 1 238 ? -0.605  -34.415 37.628 1.00 68.19  ? 264 SER B N   1 
ATOM   4812 C CA  . SER B 1 238 ? -0.883  -35.838 37.814 1.00 67.07  ? 264 SER B CA  1 
ATOM   4813 C C   . SER B 1 238 ? -2.340  -36.190 37.557 1.00 68.82  ? 264 SER B C   1 
ATOM   4814 O O   . SER B 1 238 ? -2.647  -37.359 37.285 1.00 75.76  ? 264 SER B O   1 
ATOM   4815 C CB  . SER B 1 238 ? -0.573  -36.245 39.272 1.00 76.10  ? 264 SER B CB  1 
ATOM   4816 O OG  . SER B 1 238 ? 0.696   -35.800 39.714 1.00 82.21  ? 264 SER B OG  1 
ATOM   4817 N N   . GLN B 1 239 ? -3.225  -35.202 37.541 1.00 71.01  ? 265 GLN B N   1 
ATOM   4818 C CA  . GLN B 1 239 ? -4.631  -35.487 37.326 1.00 76.31  ? 265 GLN B CA  1 
ATOM   4819 C C   . GLN B 1 239 ? -4.924  -35.901 35.873 1.00 68.41  ? 265 GLN B C   1 
ATOM   4820 O O   . GLN B 1 239 ? -4.131  -35.665 34.954 1.00 70.10  ? 265 GLN B O   1 
ATOM   4821 C CB  . GLN B 1 239 ? -5.424  -34.263 37.760 1.00 74.18  ? 265 GLN B CB  1 
ATOM   4822 C CG  . GLN B 1 239 ? -5.424  -34.027 39.262 1.00 74.02  ? 265 GLN B CG  1 
ATOM   4823 C CD  . GLN B 1 239 ? -6.658  -34.624 39.934 1.00 83.22  ? 265 GLN B CD  1 
ATOM   4824 O OE1 . GLN B 1 239 ? -7.763  -34.090 39.820 1.00 86.89  ? 265 GLN B OE1 1 
ATOM   4825 N NE2 . GLN B 1 239 ? -6.472  -35.742 40.634 1.00 83.84  ? 265 GLN B NE2 1 
ATOM   4826 N N   . TYR B 1 245 ? 3.920   -37.723 42.379 1.00 85.57  ? 271 TYR B N   1 
ATOM   4827 C CA  . TYR B 1 245 ? 4.234   -36.702 43.386 1.00 83.79  ? 271 TYR B CA  1 
ATOM   4828 C C   . TYR B 1 245 ? 4.474   -37.292 44.787 1.00 86.69  ? 271 TYR B C   1 
ATOM   4829 O O   . TYR B 1 245 ? 4.121   -38.447 45.061 1.00 82.08  ? 271 TYR B O   1 
ATOM   4830 C CB  . TYR B 1 245 ? 3.105   -35.656 43.457 1.00 78.12  ? 271 TYR B CB  1 
ATOM   4831 C CG  . TYR B 1 245 ? 1.717   -36.248 43.620 1.00 78.75  ? 271 TYR B CG  1 
ATOM   4832 C CD1 . TYR B 1 245 ? 0.984   -36.656 42.515 1.00 81.85  ? 271 TYR B CD1 1 
ATOM   4833 C CD2 . TYR B 1 245 ? 1.144   -36.409 44.873 1.00 80.55  ? 271 TYR B CD2 1 
ATOM   4834 C CE1 . TYR B 1 245 ? -0.281  -37.206 42.643 1.00 80.04  ? 271 TYR B CE1 1 
ATOM   4835 C CE2 . TYR B 1 245 ? -0.120  -36.971 45.016 1.00 85.80  ? 271 TYR B CE2 1 
ATOM   4836 C CZ  . TYR B 1 245 ? -0.836  -37.362 43.889 1.00 86.04  ? 271 TYR B CZ  1 
ATOM   4837 O OH  . TYR B 1 245 ? -2.103  -37.915 44.000 1.00 88.59  ? 271 TYR B OH  1 
ATOM   4838 N N   . GLY B 1 246 ? 5.051   -36.479 45.678 1.00 85.03  ? 272 GLY B N   1 
ATOM   4839 C CA  . GLY B 1 246 ? 5.374   -36.924 47.025 1.00 83.55  ? 272 GLY B CA  1 
ATOM   4840 C C   . GLY B 1 246 ? 4.742   -36.130 48.158 1.00 82.80  ? 272 GLY B C   1 
ATOM   4841 O O   . GLY B 1 246 ? 3.837   -35.310 47.939 1.00 79.36  ? 272 GLY B O   1 
ATOM   4842 N N   . ARG B 1 247 ? 5.208   -36.380 49.388 1.00 76.15  ? 273 ARG B N   1 
ATOM   4843 C CA  . ARG B 1 247 ? 4.671   -35.680 50.552 1.00 80.34  ? 273 ARG B CA  1 
ATOM   4844 C C   . ARG B 1 247 ? 4.902   -34.179 50.453 1.00 76.58  ? 273 ARG B C   1 
ATOM   4845 O O   . ARG B 1 247 ? 4.178   -33.397 51.091 1.00 70.67  ? 273 ARG B O   1 
ATOM   4846 C CB  . ARG B 1 247 ? 5.307   -36.234 51.843 1.00 80.93  ? 273 ARG B CB  1 
ATOM   4847 C CG  . ARG B 1 247 ? 5.166   -37.760 52.031 1.00 83.78  ? 273 ARG B CG  1 
ATOM   4848 C CD  . ARG B 1 247 ? 6.503   -38.446 52.331 1.00 90.28  ? 273 ARG B CD  1 
ATOM   4849 N NE  . ARG B 1 247 ? 7.301   -37.707 53.310 1.00 87.76  ? 273 ARG B NE  1 
ATOM   4850 C CZ  . ARG B 1 247 ? 7.375   -38.015 54.602 1.00 91.26  ? 273 ARG B CZ  1 
ATOM   4851 N NH1 . ARG B 1 247 ? 6.696   -39.057 55.063 1.00 93.93  ? 273 ARG B NH1 1 
ATOM   4852 N NH2 . ARG B 1 247 ? 8.129   -37.290 55.436 1.00 88.62  ? 273 ARG B NH2 1 
ATOM   4853 N N   . GLU B 1 248 ? 5.865   -33.756 49.629 1.00 70.21  ? 274 GLU B N   1 
ATOM   4854 C CA  . GLU B 1 248 ? 6.212   -32.344 49.535 1.00 72.03  ? 274 GLU B CA  1 
ATOM   4855 C C   . GLU B 1 248 ? 5.184   -31.512 48.765 1.00 68.71  ? 274 GLU B C   1 
ATOM   4856 O O   . GLU B 1 248 ? 5.250   -30.283 48.829 1.00 65.59  ? 274 GLU B O   1 
ATOM   4857 C CB  . GLU B 1 248 ? 7.607   -32.175 48.915 1.00 74.44  ? 274 GLU B CB  1 
ATOM   4858 C CG  . GLU B 1 248 ? 7.736   -32.470 47.427 1.00 80.31  ? 274 GLU B CG  1 
ATOM   4859 C CD  . GLU B 1 248 ? 7.958   -33.944 47.110 1.00 83.87  ? 274 GLU B CD  1 
ATOM   4860 O OE1 . GLU B 1 248 ? 8.022   -34.770 48.043 1.00 82.94  ? 274 GLU B OE1 1 
ATOM   4861 O OE2 . GLU B 1 248 ? 8.069   -34.284 45.912 1.00 91.39  ? 274 GLU B OE2 1 
ATOM   4862 N N   . CYS B 1 249 ? 4.236   -32.117 48.042 1.00 65.13  ? 275 CYS B N   1 
ATOM   4863 C CA  . CYS B 1 249 ? 3.130   -31.288 47.572 1.00 64.37  ? 275 CYS B CA  1 
ATOM   4864 C C   . CYS B 1 249 ? 2.457   -30.532 48.728 1.00 66.00  ? 275 CYS B C   1 
ATOM   4865 O O   . CYS B 1 249 ? 1.974   -29.409 48.531 1.00 61.07  ? 275 CYS B O   1 
ATOM   4866 C CB  . CYS B 1 249 ? 2.134   -32.099 46.749 1.00 63.06  ? 275 CYS B CB  1 
ATOM   4867 S SG  . CYS B 1 249 ? 1.230   -33.418 47.577 1.00 74.25  ? 275 CYS B SG  1 
ATOM   4868 N N   . ASP B 1 250 ? 2.360   -31.138 49.921 1.00 63.77  ? 276 ASP B N   1 
ATOM   4869 C CA  . ASP B 1 250 ? 1.710   -30.451 51.044 1.00 62.83  ? 276 ASP B CA  1 
ATOM   4870 C C   . ASP B 1 250 ? 2.465   -29.191 51.486 1.00 63.14  ? 276 ASP B C   1 
ATOM   4871 O O   . ASP B 1 250 ? 1.834   -28.211 51.911 1.00 61.66  ? 276 ASP B O   1 
ATOM   4872 C CB  . ASP B 1 250 ? 1.500   -31.422 52.219 1.00 66.50  ? 276 ASP B CB  1 
ATOM   4873 C CG  . ASP B 1 250 ? 0.450   -32.479 51.901 1.00 68.18  ? 276 ASP B CG  1 
ATOM   4874 O OD1 . ASP B 1 250 ? -0.395  -32.212 51.022 1.00 67.02  ? 276 ASP B OD1 1 
ATOM   4875 O OD2 . ASP B 1 250 ? 0.465   -33.574 52.500 1.00 65.80  ? 276 ASP B OD2 1 
ATOM   4876 N N   . TRP B 1 251 ? 3.800   -29.173 51.373 1.00 60.14  ? 277 TRP B N   1 
ATOM   4877 C CA  . TRP B 1 251 ? 4.559   -27.982 51.768 1.00 58.82  ? 277 TRP B CA  1 
ATOM   4878 C C   . TRP B 1 251 ? 4.361   -26.821 50.802 1.00 61.60  ? 277 TRP B C   1 
ATOM   4879 O O   . TRP B 1 251 ? 4.468   -25.655 51.205 1.00 60.40  ? 277 TRP B O   1 
ATOM   4880 C CB  . TRP B 1 251 ? 6.056   -28.310 51.881 1.00 65.04  ? 277 TRP B CB  1 
ATOM   4881 C CG  . TRP B 1 251 ? 6.344   -29.536 52.716 1.00 69.33  ? 277 TRP B CG  1 
ATOM   4882 C CD1 . TRP B 1 251 ? 7.162   -30.582 52.382 1.00 68.18  ? 277 TRP B CD1 1 
ATOM   4883 C CD2 . TRP B 1 251 ? 5.793   -29.854 54.009 1.00 65.63  ? 277 TRP B CD2 1 
ATOM   4884 N NE1 . TRP B 1 251 ? 7.162   -31.522 53.388 1.00 71.65  ? 277 TRP B NE1 1 
ATOM   4885 C CE2 . TRP B 1 251 ? 6.326   -31.106 54.392 1.00 65.33  ? 277 TRP B CE2 1 
ATOM   4886 C CE3 . TRP B 1 251 ? 4.893   -29.209 54.871 1.00 64.34  ? 277 TRP B CE3 1 
ATOM   4887 C CZ2 . TRP B 1 251 ? 5.999   -31.720 55.605 1.00 62.48  ? 277 TRP B CZ2 1 
ATOM   4888 C CZ3 . TRP B 1 251 ? 4.572   -29.827 56.086 1.00 63.73  ? 277 TRP B CZ3 1 
ATOM   4889 C CH2 . TRP B 1 251 ? 5.131   -31.065 56.438 1.00 60.37  ? 277 TRP B CH2 1 
ATOM   4890 N N   . TRP B 1 252 ? 4.138   -27.112 49.516 1.00 63.95  ? 278 TRP B N   1 
ATOM   4891 C CA  . TRP B 1 252 ? 3.743   -26.061 48.587 1.00 60.56  ? 278 TRP B CA  1 
ATOM   4892 C C   . TRP B 1 252 ? 2.468   -25.383 49.072 1.00 62.12  ? 278 TRP B C   1 
ATOM   4893 O O   . TRP B 1 252 ? 2.346   -24.144 49.036 1.00 58.36  ? 278 TRP B O   1 
ATOM   4894 C CB  . TRP B 1 252 ? 3.528   -26.650 47.191 1.00 61.06  ? 278 TRP B CB  1 
ATOM   4895 C CG  . TRP B 1 252 ? 2.795   -25.702 46.250 1.00 65.20  ? 278 TRP B CG  1 
ATOM   4896 C CD1 . TRP B 1 252 ? 1.432   -25.422 46.227 1.00 65.61  ? 278 TRP B CD1 1 
ATOM   4897 C CD2 . TRP B 1 252 ? 3.381   -24.895 45.224 1.00 62.93  ? 278 TRP B CD2 1 
ATOM   4898 N NE1 . TRP B 1 252 ? 1.159   -24.498 45.248 1.00 64.46  ? 278 TRP B NE1 1 
ATOM   4899 C CE2 . TRP B 1 252 ? 2.330   -24.164 44.611 1.00 69.54  ? 278 TRP B CE2 1 
ATOM   4900 C CE3 . TRP B 1 252 ? 4.686   -24.743 44.738 1.00 66.50  ? 278 TRP B CE3 1 
ATOM   4901 C CZ2 . TRP B 1 252 ? 2.553   -23.286 43.537 1.00 69.30  ? 278 TRP B CZ2 1 
ATOM   4902 C CZ3 . TRP B 1 252 ? 4.906   -23.863 43.676 1.00 72.37  ? 278 TRP B CZ3 1 
ATOM   4903 C CH2 . TRP B 1 252 ? 3.839   -23.148 43.087 1.00 68.73  ? 278 TRP B CH2 1 
ATOM   4904 N N   . SER B 1 253 ? 1.493   -26.185 49.512 1.00 58.37  ? 279 SER B N   1 
ATOM   4905 C CA  . SER B 1 253 ? 0.263   -25.589 50.016 1.00 60.36  ? 279 SER B CA  1 
ATOM   4906 C C   . SER B 1 253 ? 0.548   -24.687 51.206 1.00 62.67  ? 279 SER B C   1 
ATOM   4907 O O   . SER B 1 253 ? -0.123  -23.663 51.388 1.00 58.00  ? 279 SER B O   1 
ATOM   4908 C CB  . SER B 1 253 ? -0.722  -26.690 50.414 1.00 62.83  ? 279 SER B CB  1 
ATOM   4909 O OG  . SER B 1 253 ? -0.976  -27.554 49.317 1.00 63.92  ? 279 SER B OG  1 
ATOM   4910 N N   . VAL B 1 254 ? 1.575   -25.017 51.997 1.00 57.78  ? 280 VAL B N   1 
ATOM   4911 C CA  . VAL B 1 254 ? 1.890   -24.173 53.144 1.00 56.21  ? 280 VAL B CA  1 
ATOM   4912 C C   . VAL B 1 254 ? 2.389   -22.812 52.686 1.00 54.86  ? 280 VAL B C   1 
ATOM   4913 O O   . VAL B 1 254 ? 2.030   -21.777 53.268 1.00 57.25  ? 280 VAL B O   1 
ATOM   4914 C CB  . VAL B 1 254 ? 2.889   -24.873 54.085 1.00 62.97  ? 280 VAL B CB  1 
ATOM   4915 C CG1 . VAL B 1 254 ? 3.169   -23.996 55.317 1.00 50.43  ? 280 VAL B CG1 1 
ATOM   4916 C CG2 . VAL B 1 254 ? 2.338   -26.211 54.498 1.00 57.37  ? 280 VAL B CG2 1 
ATOM   4917 N N   . GLY B 1 255 ? 3.197   -22.778 51.626 1.00 57.00  ? 281 GLY B N   1 
ATOM   4918 C CA  . GLY B 1 255 ? 3.630   -21.494 51.089 1.00 59.31  ? 281 GLY B CA  1 
ATOM   4919 C C   . GLY B 1 255 ? 2.466   -20.637 50.628 1.00 57.15  ? 281 GLY B C   1 
ATOM   4920 O O   . GLY B 1 255 ? 2.425   -19.432 50.895 1.00 58.75  ? 281 GLY B O   1 
ATOM   4921 N N   . VAL B 1 256 ? 1.484   -21.254 49.962 1.00 58.01  ? 282 VAL B N   1 
ATOM   4922 C CA  . VAL B 1 256 ? 0.319   -20.509 49.484 1.00 55.79  ? 282 VAL B CA  1 
ATOM   4923 C C   . VAL B 1 256 ? -0.432  -19.914 50.659 1.00 61.35  ? 282 VAL B C   1 
ATOM   4924 O O   . VAL B 1 256 ? -0.842  -18.743 50.637 1.00 60.59  ? 282 VAL B O   1 
ATOM   4925 C CB  . VAL B 1 256 ? -0.592  -21.418 48.638 1.00 59.15  ? 282 VAL B CB  1 
ATOM   4926 C CG1 . VAL B 1 256 ? -1.763  -20.626 48.073 1.00 60.16  ? 282 VAL B CG1 1 
ATOM   4927 C CG2 . VAL B 1 256 ? 0.201   -22.093 47.535 1.00 59.82  ? 282 VAL B CG2 1 
ATOM   4928 N N   . PHE B 1 257 ? -0.641  -20.738 51.696 1.00 61.55  ? 283 PHE B N   1 
ATOM   4929 C CA  . PHE B 1 257 ? -1.254  -20.307 52.951 1.00 57.37  ? 283 PHE B CA  1 
ATOM   4930 C C   . PHE B 1 257 ? -0.509  -19.130 53.581 1.00 61.49  ? 283 PHE B C   1 
ATOM   4931 O O   . PHE B 1 257 ? -1.118  -18.115 53.953 1.00 57.28  ? 283 PHE B O   1 
ATOM   4932 C CB  . PHE B 1 257 ? -1.277  -21.498 53.918 1.00 56.99  ? 283 PHE B CB  1 
ATOM   4933 C CG  . PHE B 1 257 ? -1.838  -21.179 55.271 1.00 60.95  ? 283 PHE B CG  1 
ATOM   4934 C CD1 . PHE B 1 257 ? -3.026  -20.474 55.397 1.00 59.53  ? 283 PHE B CD1 1 
ATOM   4935 C CD2 . PHE B 1 257 ? -1.174  -21.585 56.427 1.00 64.61  ? 283 PHE B CD2 1 
ATOM   4936 C CE1 . PHE B 1 257 ? -3.544  -20.175 56.655 1.00 60.79  ? 283 PHE B CE1 1 
ATOM   4937 C CE2 . PHE B 1 257 ? -1.689  -21.296 57.689 1.00 61.36  ? 283 PHE B CE2 1 
ATOM   4938 C CZ  . PHE B 1 257 ? -2.871  -20.592 57.799 1.00 63.68  ? 283 PHE B CZ  1 
ATOM   4939 N N   . LEU B 1 258 ? 0.813   -19.255 53.739 1.00 57.66  ? 284 LEU B N   1 
ATOM   4940 C CA  . LEU B 1 258 ? 1.550   -18.192 54.418 1.00 60.04  ? 284 LEU B CA  1 
ATOM   4941 C C   . LEU B 1 258 ? 1.513   -16.902 53.613 1.00 64.38  ? 284 LEU B C   1 
ATOM   4942 O O   . LEU B 1 258 ? 1.359   -15.813 54.181 1.00 66.22  ? 284 LEU B O   1 
ATOM   4943 C CB  . LEU B 1 258 ? 2.992   -18.618 54.670 1.00 59.28  ? 284 LEU B CB  1 
ATOM   4944 C CG  . LEU B 1 258 ? 3.874   -17.560 55.340 1.00 61.47  ? 284 LEU B CG  1 
ATOM   4945 C CD1 . LEU B 1 258 ? 3.219   -17.012 56.600 1.00 64.14  ? 284 LEU B CD1 1 
ATOM   4946 C CD2 . LEU B 1 258 ? 5.263   -18.144 55.637 1.00 62.99  ? 284 LEU B CD2 1 
ATOM   4947 N N   . TYR B 1 259 ? 1.635   -17.013 52.288 1.00 64.18  ? 285 TYR B N   1 
ATOM   4948 C CA  . TYR B 1 259 ? 1.472   -15.847 51.426 1.00 65.96  ? 285 TYR B CA  1 
ATOM   4949 C C   . TYR B 1 259 ? 0.128   -15.175 51.671 1.00 64.57  ? 285 TYR B C   1 
ATOM   4950 O O   . TYR B 1 259 ? 0.065   -13.967 51.921 1.00 66.78  ? 285 TYR B O   1 
ATOM   4951 C CB  . TYR B 1 259 ? 1.613   -16.271 49.958 1.00 67.10  ? 285 TYR B CB  1 
ATOM   4952 C CG  . TYR B 1 259 ? 1.575   -15.140 48.948 1.00 71.04  ? 285 TYR B CG  1 
ATOM   4953 C CD1 . TYR B 1 259 ? 0.369   -14.535 48.593 1.00 69.93  ? 285 TYR B CD1 1 
ATOM   4954 C CD2 . TYR B 1 259 ? 2.745   -14.693 48.327 1.00 73.21  ? 285 TYR B CD2 1 
ATOM   4955 C CE1 . TYR B 1 259 ? 0.328   -13.505 47.666 1.00 72.53  ? 285 TYR B CE1 1 
ATOM   4956 C CE2 . TYR B 1 259 ? 2.717   -13.665 47.396 1.00 76.89  ? 285 TYR B CE2 1 
ATOM   4957 C CZ  . TYR B 1 259 ? 1.505   -13.076 47.070 1.00 77.65  ? 285 TYR B CZ  1 
ATOM   4958 O OH  . TYR B 1 259 ? 1.465   -12.052 46.149 1.00 78.79  ? 285 TYR B OH  1 
ATOM   4959 N N   . GLU B 1 260 ? -0.963  -15.948 51.624 1.00 63.48  ? 286 GLU B N   1 
ATOM   4960 C CA  . GLU B 1 260 ? -2.285  -15.343 51.771 1.00 67.47  ? 286 GLU B CA  1 
ATOM   4961 C C   . GLU B 1 260 ? -2.457  -14.660 53.124 1.00 70.31  ? 286 GLU B C   1 
ATOM   4962 O O   . GLU B 1 260 ? -3.106  -13.612 53.213 1.00 69.56  ? 286 GLU B O   1 
ATOM   4963 C CB  . GLU B 1 260 ? -3.389  -16.372 51.576 1.00 66.21  ? 286 GLU B CB  1 
ATOM   4964 C CG  . GLU B 1 260 ? -4.745  -15.681 51.508 1.00 67.92  ? 286 GLU B CG  1 
ATOM   4965 C CD  . GLU B 1 260 ? -5.911  -16.644 51.509 1.00 69.44  ? 286 GLU B CD  1 
ATOM   4966 O OE1 . GLU B 1 260 ? -5.696  -17.860 51.306 1.00 67.05  ? 286 GLU B OE1 1 
ATOM   4967 O OE2 . GLU B 1 260 ? -7.052  -16.180 51.714 1.00 70.18  ? 286 GLU B OE2 1 
ATOM   4968 N N   . MET B 1 261 ? -1.923  -15.251 54.196 1.00 64.09  ? 287 MET B N   1 
ATOM   4969 C CA  . MET B 1 261 ? -2.055  -14.617 55.505 1.00 69.65  ? 287 MET B CA  1 
ATOM   4970 C C   . MET B 1 261 ? -1.358  -13.252 55.541 1.00 71.59  ? 287 MET B C   1 
ATOM   4971 O O   . MET B 1 261 ? -1.912  -12.268 56.053 1.00 70.37  ? 287 MET B O   1 
ATOM   4972 C CB  . MET B 1 261 ? -1.486  -15.542 56.581 1.00 73.01  ? 287 MET B CB  1 
ATOM   4973 C CG  . MET B 1 261 ? -2.499  -16.508 57.200 1.00 70.15  ? 287 MET B CG  1 
ATOM   4974 S SD  . MET B 1 261 ? -1.798  -17.332 58.652 1.00 79.56  ? 287 MET B SD  1 
ATOM   4975 C CE  . MET B 1 261 ? -0.358  -18.157 57.928 1.00 63.97  ? 287 MET B CE  1 
ATOM   4976 N N   . LEU B 1 262 ? -0.152  -13.170 54.984 1.00 68.92  ? 288 LEU B N   1 
ATOM   4977 C CA  . LEU B 1 262 ? 0.632   -11.944 55.056 1.00 73.52  ? 288 LEU B CA  1 
ATOM   4978 C C   . LEU B 1 262 ? 0.321   -10.956 53.938 1.00 76.41  ? 288 LEU B C   1 
ATOM   4979 O O   . LEU B 1 262 ? 0.472   -9.745  54.138 1.00 78.53  ? 288 LEU B O   1 
ATOM   4980 C CB  . LEU B 1 262 ? 2.122   -12.280 55.017 1.00 72.46  ? 288 LEU B CB  1 
ATOM   4981 C CG  . LEU B 1 262 ? 2.588   -13.158 56.170 1.00 72.91  ? 288 LEU B CG  1 
ATOM   4982 C CD1 . LEU B 1 262 ? 4.056   -13.520 55.973 1.00 71.42  ? 288 LEU B CD1 1 
ATOM   4983 C CD2 . LEU B 1 262 ? 2.335   -12.456 57.512 1.00 69.51  ? 288 LEU B CD2 1 
ATOM   4984 N N   . VAL B 1 263 ? -0.134  -11.426 52.779 1.00 76.57  ? 289 VAL B N   1 
ATOM   4985 C CA  . VAL B 1 263 ? -0.376  -10.553 51.637 1.00 74.13  ? 289 VAL B CA  1 
ATOM   4986 C C   . VAL B 1 263 ? -1.835  -10.124 51.559 1.00 73.82  ? 289 VAL B C   1 
ATOM   4987 O O   . VAL B 1 263 ? -2.125  -8.971  51.239 1.00 77.65  ? 289 VAL B O   1 
ATOM   4988 C CB  . VAL B 1 263 ? 0.055   -11.246 50.326 1.00 73.30  ? 289 VAL B CB  1 
ATOM   4989 C CG1 . VAL B 1 263 ? -0.441  -10.443 49.108 1.00 74.65  ? 289 VAL B CG1 1 
ATOM   4990 C CG2 . VAL B 1 263 ? 1.559   -11.447 50.297 1.00 70.72  ? 289 VAL B CG2 1 
ATOM   4991 N N   . GLY B 1 264 ? -2.762  -11.030 51.872 1.00 74.96  ? 290 GLY B N   1 
ATOM   4992 C CA  . GLY B 1 264 ? -4.188  -10.784 51.739 1.00 77.46  ? 290 GLY B CA  1 
ATOM   4993 C C   . GLY B 1 264 ? -4.852  -11.483 50.564 1.00 79.45  ? 290 GLY B C   1 
ATOM   4994 O O   . GLY B 1 264 ? -6.091  -11.498 50.493 1.00 80.45  ? 290 GLY B O   1 
ATOM   4995 N N   . ASP B 1 265 ? -4.080  -12.026 49.624 1.00 78.29  ? 291 ASP B N   1 
ATOM   4996 C CA  . ASP B 1 265 ? -4.627  -12.783 48.506 1.00 74.93  ? 291 ASP B CA  1 
ATOM   4997 C C   . ASP B 1 265 ? -3.761  -14.007 48.280 1.00 69.35  ? 291 ASP B C   1 
ATOM   4998 O O   . ASP B 1 265 ? -2.606  -14.049 48.699 1.00 70.90  ? 291 ASP B O   1 
ATOM   4999 C CB  . ASP B 1 265 ? -4.680  -11.959 47.209 1.00 84.10  ? 291 ASP B CB  1 
ATOM   5000 C CG  . ASP B 1 265 ? -5.881  -11.035 47.142 1.00 87.73  ? 291 ASP B CG  1 
ATOM   5001 O OD1 . ASP B 1 265 ? -6.997  -11.524 46.857 1.00 91.17  ? 291 ASP B OD1 1 
ATOM   5002 O OD2 . ASP B 1 265 ? -5.701  -9.820  47.365 1.00 87.45  ? 291 ASP B OD2 1 
ATOM   5003 N N   . THR B 1 266 ? -4.311  -14.992 47.579 1.00 70.98  ? 292 THR B N   1 
ATOM   5004 C CA  . THR B 1 266 ? -3.497  -16.127 47.184 1.00 70.86  ? 292 THR B CA  1 
ATOM   5005 C C   . THR B 1 266 ? -2.552  -15.683 46.072 1.00 69.91  ? 292 THR B C   1 
ATOM   5006 O O   . THR B 1 266 ? -2.881  -14.782 45.298 1.00 69.85  ? 292 THR B O   1 
ATOM   5007 C CB  . THR B 1 266 ? -4.366  -17.292 46.708 1.00 70.18  ? 292 THR B CB  1 
ATOM   5008 O OG1 . THR B 1 266 ? -5.224  -16.849 45.651 1.00 70.78  ? 292 THR B OG1 1 
ATOM   5009 C CG2 . THR B 1 266 ? -5.217  -17.842 47.865 1.00 66.81  ? 292 THR B CG2 1 
ATOM   5010 N N   . PRO B 1 267 ? -1.351  -16.266 45.998 1.00 66.26  ? 293 PRO B N   1 
ATOM   5011 C CA  . PRO B 1 267 ? -0.333  -15.737 45.080 1.00 67.91  ? 293 PRO B CA  1 
ATOM   5012 C C   . PRO B 1 267 ? -0.606  -16.015 43.608 1.00 70.90  ? 293 PRO B C   1 
ATOM   5013 O O   . PRO B 1 267 ? 0.021   -15.372 42.761 1.00 69.09  ? 293 PRO B O   1 
ATOM   5014 C CB  . PRO B 1 267 ? 0.942   -16.444 45.543 1.00 68.72  ? 293 PRO B CB  1 
ATOM   5015 C CG  . PRO B 1 267 ? 0.442   -17.745 46.043 1.00 70.62  ? 293 PRO B CG  1 
ATOM   5016 C CD  . PRO B 1 267 ? -0.850  -17.421 46.756 1.00 67.62  ? 293 PRO B CD  1 
ATOM   5017 N N   . PHE B 1 268 ? -1.529  -16.919 43.276 1.00 71.17  ? 294 PHE B N   1 
ATOM   5018 C CA  . PHE B 1 268 ? -1.838  -17.242 41.891 1.00 64.26  ? 294 PHE B CA  1 
ATOM   5019 C C   . PHE B 1 268 ? -3.326  -17.094 41.609 1.00 67.95  ? 294 PHE B C   1 
ATOM   5020 O O   . PHE B 1 268 ? -3.885  -17.844 40.806 1.00 69.52  ? 294 PHE B O   1 
ATOM   5021 C CB  . PHE B 1 268 ? -1.377  -18.654 41.550 1.00 64.84  ? 294 PHE B CB  1 
ATOM   5022 C CG  . PHE B 1 268 ? 0.007   -18.957 42.028 1.00 70.76  ? 294 PHE B CG  1 
ATOM   5023 C CD1 . PHE B 1 268 ? 1.104   -18.367 41.422 1.00 70.49  ? 294 PHE B CD1 1 
ATOM   5024 C CD2 . PHE B 1 268 ? 0.216   -19.816 43.095 1.00 69.90  ? 294 PHE B CD2 1 
ATOM   5025 C CE1 . PHE B 1 268 ? 2.393   -18.636 41.868 1.00 76.64  ? 294 PHE B CE1 1 
ATOM   5026 C CE2 . PHE B 1 268 ? 1.500   -20.092 43.545 1.00 70.01  ? 294 PHE B CE2 1 
ATOM   5027 C CZ  . PHE B 1 268 ? 2.589   -19.503 42.934 1.00 73.00  ? 294 PHE B CZ  1 
ATOM   5028 N N   . TYR B 1 269 ? -3.978  -16.134 42.265 1.00 67.93  ? 295 TYR B N   1 
ATOM   5029 C CA  . TYR B 1 269 ? -5.377  -15.846 41.977 1.00 74.39  ? 295 TYR B CA  1 
ATOM   5030 C C   . TYR B 1 269 ? -5.540  -15.328 40.547 1.00 74.12  ? 295 TYR B C   1 
ATOM   5031 O O   . TYR B 1 269 ? -4.683  -14.612 40.022 1.00 68.03  ? 295 TYR B O   1 
ATOM   5032 C CB  . TYR B 1 269 ? -5.945  -14.817 42.969 1.00 73.68  ? 295 TYR B CB  1 
ATOM   5033 C CG  . TYR B 1 269 ? -7.371  -14.419 42.623 1.00 82.33  ? 295 TYR B CG  1 
ATOM   5034 C CD1 . TYR B 1 269 ? -8.444  -15.250 42.949 1.00 83.61  ? 295 TYR B CD1 1 
ATOM   5035 C CD2 . TYR B 1 269 ? -7.644  -13.236 41.928 1.00 81.52  ? 295 TYR B CD2 1 
ATOM   5036 C CE1 . TYR B 1 269 ? -9.755  -14.906 42.609 1.00 86.27  ? 295 TYR B CE1 1 
ATOM   5037 C CE2 . TYR B 1 269 ? -8.952  -12.883 41.583 1.00 81.73  ? 295 TYR B CE2 1 
ATOM   5038 C CZ  . TYR B 1 269 ? -10.001 -13.723 41.927 1.00 85.82  ? 295 TYR B CZ  1 
ATOM   5039 O OH  . TYR B 1 269 ? -11.295 -13.385 41.590 1.00 84.31  ? 295 TYR B OH  1 
ATOM   5040 N N   . ALA B 1 270 ? -6.618  -15.749 39.894 1.00 79.15  ? 296 ALA B N   1 
ATOM   5041 C CA  . ALA B 1 270 ? -7.056  -15.149 38.638 1.00 79.77  ? 296 ALA B CA  1 
ATOM   5042 C C   . ALA B 1 270 ? -8.574  -15.182 38.626 1.00 77.75  ? 296 ALA B C   1 
ATOM   5043 O O   . ALA B 1 270 ? -9.202  -15.836 39.462 1.00 80.29  ? 296 ALA B O   1 
ATOM   5044 C CB  . ALA B 1 270 ? -6.472  -15.858 37.406 1.00 73.07  ? 296 ALA B CB  1 
ATOM   5045 N N   . ASP B 1 271 ? -9.161  -14.468 37.660 1.00 79.88  ? 297 ASP B N   1 
ATOM   5046 C CA  . ASP B 1 271 ? -10.616 -14.394 37.541 1.00 80.89  ? 297 ASP B CA  1 
ATOM   5047 C C   . ASP B 1 271 ? -11.236 -15.728 37.136 1.00 79.33  ? 297 ASP B C   1 
ATOM   5048 O O   . ASP B 1 271 ? -12.430 -15.936 37.367 1.00 82.36  ? 297 ASP B O   1 
ATOM   5049 C CB  . ASP B 1 271 ? -11.004 -13.329 36.513 1.00 87.73  ? 297 ASP B CB  1 
ATOM   5050 C CG  . ASP B 1 271 ? -10.177 -13.427 35.228 1.00 93.85  ? 297 ASP B CG  1 
ATOM   5051 O OD1 . ASP B 1 271 ? -9.442  -14.437 35.050 1.00 92.75  ? 297 ASP B OD1 1 
ATOM   5052 O OD2 . ASP B 1 271 ? -10.246 -12.487 34.398 1.00 100.35 ? 297 ASP B OD2 1 
ATOM   5053 N N   . SER B 1 272 ? -10.452 -16.626 36.542 1.00 76.04  ? 298 SER B N   1 
ATOM   5054 C CA  . SER B 1 272 ? -10.932 -17.873 35.965 1.00 73.93  ? 298 SER B CA  1 
ATOM   5055 C C   . SER B 1 272 ? -10.169 -19.041 36.574 1.00 73.14  ? 298 SER B C   1 
ATOM   5056 O O   . SER B 1 272 ? -9.018  -18.898 37.013 1.00 73.11  ? 298 SER B O   1 
ATOM   5057 C CB  . SER B 1 272 ? -10.737 -17.885 34.434 1.00 75.26  ? 298 SER B CB  1 
ATOM   5058 O OG  . SER B 1 272 ? -11.197 -19.109 33.856 1.00 82.10  ? 298 SER B OG  1 
ATOM   5059 N N   . LEU B 1 273 ? -10.818 -20.213 36.575 1.00 66.87  ? 299 LEU B N   1 
ATOM   5060 C CA  . LEU B 1 273 ? -10.124 -21.432 36.982 1.00 69.31  ? 299 LEU B CA  1 
ATOM   5061 C C   . LEU B 1 273 ? -8.892  -21.700 36.114 1.00 69.45  ? 299 LEU B C   1 
ATOM   5062 O O   . LEU B 1 273 ? -7.817  -22.032 36.634 1.00 66.47  ? 299 LEU B O   1 
ATOM   5063 C CB  . LEU B 1 273 ? -11.073 -22.623 36.940 1.00 63.43  ? 299 LEU B CB  1 
ATOM   5064 C CG  . LEU B 1 273 ? -10.381 -23.922 37.382 1.00 71.71  ? 299 LEU B CG  1 
ATOM   5065 C CD1 . LEU B 1 273 ? -11.146 -24.606 38.511 1.00 67.48  ? 299 LEU B CD1 1 
ATOM   5066 C CD2 . LEU B 1 273 ? -10.137 -24.882 36.203 1.00 65.51  ? 299 LEU B CD2 1 
ATOM   5067 N N   . VAL B 1 274 ? -9.021  -21.552 34.792 1.00 66.15  ? 300 VAL B N   1 
ATOM   5068 C CA  . VAL B 1 274 ? -7.902  -21.895 33.915 1.00 67.07  ? 300 VAL B CA  1 
ATOM   5069 C C   . VAL B 1 274 ? -6.804  -20.828 34.002 1.00 63.76  ? 300 VAL B C   1 
ATOM   5070 O O   . VAL B 1 274 ? -5.614  -21.137 33.865 1.00 68.12  ? 300 VAL B O   1 
ATOM   5071 C CB  . VAL B 1 274 ? -8.403  -22.112 32.472 1.00 67.68  ? 300 VAL B CB  1 
ATOM   5072 C CG1 . VAL B 1 274 ? -9.297  -20.944 32.021 1.00 66.35  ? 300 VAL B CG1 1 
ATOM   5073 C CG2 . VAL B 1 274 ? -7.238  -22.339 31.488 1.00 63.79  ? 300 VAL B CG2 1 
ATOM   5074 N N   . GLY B 1 275 ? -7.160  -19.579 34.300 1.00 64.77  ? 301 GLY B N   1 
ATOM   5075 C CA  . GLY B 1 275 ? -6.137  -18.582 34.593 1.00 66.26  ? 301 GLY B CA  1 
ATOM   5076 C C   . GLY B 1 275 ? -5.351  -18.878 35.870 1.00 71.73  ? 301 GLY B C   1 
ATOM   5077 O O   . GLY B 1 275 ? -4.138  -18.639 35.933 1.00 68.35  ? 301 GLY B O   1 
ATOM   5078 N N   . THR B 1 276 ? -6.032  -19.359 36.919 1.00 67.11  ? 302 THR B N   1 
ATOM   5079 C CA  . THR B 1 276 ? -5.319  -19.762 38.131 1.00 71.61  ? 302 THR B CA  1 
ATOM   5080 C C   . THR B 1 276 ? -4.386  -20.932 37.849 1.00 69.13  ? 302 THR B C   1 
ATOM   5081 O O   . THR B 1 276 ? -3.204  -20.907 38.221 1.00 66.52  ? 302 THR B O   1 
ATOM   5082 C CB  . THR B 1 276 ? -6.308  -20.117 39.248 1.00 72.01  ? 302 THR B CB  1 
ATOM   5083 O OG1 . THR B 1 276 ? -7.031  -18.944 39.641 1.00 72.42  ? 302 THR B OG1 1 
ATOM   5084 C CG2 . THR B 1 276 ? -5.561  -20.665 40.475 1.00 64.63  ? 302 THR B CG2 1 
ATOM   5085 N N   . TYR B 1 277 ? -4.907  -21.962 37.178 1.00 67.38  ? 303 TYR B N   1 
ATOM   5086 C CA  . TYR B 1 277 ? -4.116  -23.131 36.798 1.00 65.87  ? 303 TYR B CA  1 
ATOM   5087 C C   . TYR B 1 277 ? -2.876  -22.735 36.016 1.00 68.50  ? 303 TYR B C   1 
ATOM   5088 O O   . TYR B 1 277 ? -1.791  -23.288 36.238 1.00 66.74  ? 303 TYR B O   1 
ATOM   5089 C CB  . TYR B 1 277 ? -4.994  -24.075 35.971 1.00 67.36  ? 303 TYR B CB  1 
ATOM   5090 C CG  . TYR B 1 277 ? -4.316  -25.240 35.269 1.00 62.28  ? 303 TYR B CG  1 
ATOM   5091 C CD1 . TYR B 1 277 ? -3.683  -25.071 34.045 1.00 64.10  ? 303 TYR B CD1 1 
ATOM   5092 C CD2 . TYR B 1 277 ? -4.381  -26.525 35.799 1.00 64.70  ? 303 TYR B CD2 1 
ATOM   5093 C CE1 . TYR B 1 277 ? -3.086  -26.141 33.393 1.00 68.94  ? 303 TYR B CE1 1 
ATOM   5094 C CE2 . TYR B 1 277 ? -3.791  -27.598 35.158 1.00 65.49  ? 303 TYR B CE2 1 
ATOM   5095 C CZ  . TYR B 1 277 ? -3.143  -27.401 33.955 1.00 69.10  ? 303 TYR B CZ  1 
ATOM   5096 O OH  . TYR B 1 277 ? -2.557  -28.474 33.314 1.00 71.32  ? 303 TYR B OH  1 
ATOM   5097 N N   . SER B 1 278 ? -2.998  -21.745 35.127 1.00 64.78  ? 304 SER B N   1 
ATOM   5098 C CA  . SER B 1 278 ? -1.843  -21.419 34.309 1.00 68.17  ? 304 SER B CA  1 
ATOM   5099 C C   . SER B 1 278 ? -0.853  -20.528 35.054 1.00 70.91  ? 304 SER B C   1 
ATOM   5100 O O   . SER B 1 278 ? 0.361   -20.681 34.880 1.00 68.41  ? 304 SER B O   1 
ATOM   5101 C CB  . SER B 1 278 ? -2.294  -20.699 33.024 1.00 67.81  ? 304 SER B CB  1 
ATOM   5102 O OG  . SER B 1 278 ? -2.791  -21.602 32.042 1.00 82.21  ? 304 SER B OG  1 
ATOM   5103 N N   . LYS B 1 279 ? -1.328  -19.688 35.970 1.00 66.47  ? 305 LYS B N   1 
ATOM   5104 C CA  . LYS B 1 279 ? -0.391  -18.965 36.818 1.00 73.81  ? 305 LYS B CA  1 
ATOM   5105 C C   . LYS B 1 279 ? 0.429   -19.931 37.680 1.00 71.97  ? 305 LYS B C   1 
ATOM   5106 O O   . LYS B 1 279 ? 1.642   -19.743 37.844 1.00 69.82  ? 305 LYS B O   1 
ATOM   5107 C CB  . LYS B 1 279 ? -1.139  -17.938 37.665 1.00 71.98  ? 305 LYS B CB  1 
ATOM   5108 C CG  . LYS B 1 279 ? -1.450  -16.618 36.940 1.00 67.98  ? 305 LYS B CG  1 
ATOM   5109 C CD  . LYS B 1 279 ? -2.550  -15.839 37.693 1.00 76.95  ? 305 LYS B CD  1 
ATOM   5110 C CE  . LYS B 1 279 ? -2.905  -14.478 37.067 1.00 73.42  ? 305 LYS B CE  1 
ATOM   5111 N NZ  . LYS B 1 279 ? -1.836  -13.454 37.254 1.00 88.55  ? 305 LYS B NZ  1 
ATOM   5112 N N   . ILE B 1 280 ? -0.199  -21.004 38.184 1.00 66.67  ? 306 ILE B N   1 
ATOM   5113 C CA  . ILE B 1 280 ? 0.506   -21.950 39.053 1.00 71.26  ? 306 ILE B CA  1 
ATOM   5114 C C   . ILE B 1 280 ? 1.589   -22.693 38.275 1.00 73.80  ? 306 ILE B C   1 
ATOM   5115 O O   . ILE B 1 280 ? 2.740   -22.779 38.719 1.00 72.68  ? 306 ILE B O   1 
ATOM   5116 C CB  . ILE B 1 280 ? -0.487  -22.929 39.712 1.00 68.04  ? 306 ILE B CB  1 
ATOM   5117 C CG1 . ILE B 1 280 ? -1.290  -22.235 40.824 1.00 65.89  ? 306 ILE B CG1 1 
ATOM   5118 C CG2 . ILE B 1 280 ? 0.231   -24.156 40.264 1.00 65.68  ? 306 ILE B CG2 1 
ATOM   5119 C CD1 . ILE B 1 280 ? -2.591  -22.944 41.154 1.00 57.80  ? 306 ILE B CD1 1 
ATOM   5120 N N   . MET B 1 281 ? 1.240   -23.240 37.108 1.00 71.16  ? 307 MET B N   1 
ATOM   5121 C CA  . MET B 1 281 ? 2.240   -23.900 36.270 1.00 74.99  ? 307 MET B CA  1 
ATOM   5122 C C   . MET B 1 281 ? 3.336   -22.938 35.827 1.00 73.80  ? 307 MET B C   1 
ATOM   5123 O O   . MET B 1 281 ? 4.472   -23.360 35.588 1.00 78.54  ? 307 MET B O   1 
ATOM   5124 C CB  . MET B 1 281 ? 1.570   -24.539 35.061 1.00 69.65  ? 307 MET B CB  1 
ATOM   5125 C CG  . MET B 1 281 ? 0.421   -25.374 35.488 1.00 76.75  ? 307 MET B CG  1 
ATOM   5126 S SD  . MET B 1 281 ? 0.973   -26.911 36.237 1.00 75.13  ? 307 MET B SD  1 
ATOM   5127 C CE  . MET B 1 281 ? 0.339   -28.003 34.970 1.00 76.51  ? 307 MET B CE  1 
ATOM   5128 N N   . ASP B 1 282 ? 3.020   -21.652 35.697 1.00 73.02  ? 308 ASP B N   1 
ATOM   5129 C CA  . ASP B 1 282 ? 4.006   -20.624 35.369 1.00 72.24  ? 308 ASP B CA  1 
ATOM   5130 C C   . ASP B 1 282 ? 4.520   -19.929 36.622 1.00 79.94  ? 308 ASP B C   1 
ATOM   5131 O O   . ASP B 1 282 ? 4.786   -18.722 36.590 1.00 78.88  ? 308 ASP B O   1 
ATOM   5132 C CB  . ASP B 1 282 ? 3.396   -19.603 34.413 1.00 76.44  ? 308 ASP B CB  1 
ATOM   5133 C CG  . ASP B 1 282 ? 4.453   -18.765 33.677 1.00 84.09  ? 308 ASP B CG  1 
ATOM   5134 O OD1 . ASP B 1 282 ? 5.390   -19.352 33.085 1.00 80.14  ? 308 ASP B OD1 1 
ATOM   5135 O OD2 . ASP B 1 282 ? 4.336   -17.518 33.689 1.00 83.18  ? 308 ASP B OD2 1 
ATOM   5136 N N   . HIS B 1 283 ? 4.690   -20.663 37.736 1.00 74.80  ? 309 HIS B N   1 
ATOM   5137 C CA  . HIS B 1 283 ? 4.989   -20.005 39.008 1.00 78.25  ? 309 HIS B CA  1 
ATOM   5138 C C   . HIS B 1 283 ? 6.326   -19.284 38.977 1.00 80.66  ? 309 HIS B C   1 
ATOM   5139 O O   . HIS B 1 283 ? 6.464   -18.228 39.611 1.00 79.68  ? 309 HIS B O   1 
ATOM   5140 C CB  . HIS B 1 283 ? 4.974   -21.016 40.165 1.00 76.36  ? 309 HIS B CB  1 
ATOM   5141 C CG  . HIS B 1 283 ? 5.932   -22.161 39.996 1.00 73.25  ? 309 HIS B CG  1 
ATOM   5142 N ND1 . HIS B 1 283 ? 7.196   -22.165 40.548 1.00 75.66  ? 309 HIS B ND1 1 
ATOM   5143 C CD2 . HIS B 1 283 ? 5.805   -23.341 39.341 1.00 72.99  ? 309 HIS B CD2 1 
ATOM   5144 C CE1 . HIS B 1 283 ? 7.808   -23.296 40.236 1.00 77.70  ? 309 HIS B CE1 1 
ATOM   5145 N NE2 . HIS B 1 283 ? 6.986   -24.027 39.503 1.00 75.79  ? 309 HIS B NE2 1 
ATOM   5146 N N   . LYS B 1 284 ? 7.306   -19.815 38.222 1.00 80.92  ? 310 LYS B N   1 
ATOM   5147 C CA  . LYS B 1 284 ? 8.640   -19.211 38.179 1.00 85.43  ? 310 LYS B CA  1 
ATOM   5148 C C   . LYS B 1 284 ? 8.601   -17.748 37.731 1.00 87.94  ? 310 LYS B C   1 
ATOM   5149 O O   . LYS B 1 284 ? 9.476   -16.961 38.116 1.00 92.65  ? 310 LYS B O   1 
ATOM   5150 C CB  . LYS B 1 284 ? 9.563   -20.032 37.265 1.00 81.18  ? 310 LYS B CB  1 
ATOM   5151 N N   . ASN B 1 285 ? 7.583   -17.352 36.957 1.00 84.30  ? 311 ASN B N   1 
ATOM   5152 C CA  . ASN B 1 285 ? 7.432   -15.965 36.540 1.00 85.27  ? 311 ASN B CA  1 
ATOM   5153 C C   . ASN B 1 285 ? 6.210   -15.255 37.116 1.00 89.76  ? 311 ASN B C   1 
ATOM   5154 O O   . ASN B 1 285 ? 6.183   -14.019 37.105 1.00 92.05  ? 311 ASN B O   1 
ATOM   5155 C CB  . ASN B 1 285 ? 7.378   -15.874 35.004 1.00 91.69  ? 311 ASN B CB  1 
ATOM   5156 C CG  . ASN B 1 285 ? 8.497   -16.662 34.330 1.00 94.26  ? 311 ASN B CG  1 
ATOM   5157 O OD1 . ASN B 1 285 ? 9.684   -16.386 34.536 1.00 98.66  ? 311 ASN B OD1 1 
ATOM   5158 N ND2 . ASN B 1 285 ? 8.122   -17.647 33.520 1.00 92.63  ? 311 ASN B ND2 1 
ATOM   5159 N N   . SER B 1 286 ? 5.207   -15.990 37.618 1.00 89.02  ? 312 SER B N   1 
ATOM   5160 C CA  . SER B 1 286 ? 3.962   -15.385 38.093 1.00 85.51  ? 312 SER B CA  1 
ATOM   5161 C C   . SER B 1 286 ? 3.975   -15.028 39.575 1.00 85.89  ? 312 SER B C   1 
ATOM   5162 O O   . SER B 1 286 ? 3.208   -14.154 40.004 1.00 84.84  ? 312 SER B O   1 
ATOM   5163 C CB  . SER B 1 286 ? 2.782   -16.325 37.816 1.00 80.92  ? 312 SER B CB  1 
ATOM   5164 O OG  . SER B 1 286 ? 2.886   -17.512 38.584 1.00 77.42  ? 312 SER B OG  1 
ATOM   5165 N N   . LEU B 1 287 ? 4.796   -15.700 40.374 1.00 85.13  ? 313 LEU B N   1 
ATOM   5166 C CA  . LEU B 1 287 ? 4.908   -15.354 41.784 1.00 84.65  ? 313 LEU B CA  1 
ATOM   5167 C C   . LEU B 1 287 ? 5.535   -13.967 41.925 1.00 89.19  ? 313 LEU B C   1 
ATOM   5168 O O   . LEU B 1 287 ? 6.671   -13.739 41.492 1.00 88.60  ? 313 LEU B O   1 
ATOM   5169 C CB  . LEU B 1 287 ? 5.735   -16.412 42.508 1.00 86.21  ? 313 LEU B CB  1 
ATOM   5170 C CG  . LEU B 1 287 ? 6.122   -16.102 43.944 1.00 82.51  ? 313 LEU B CG  1 
ATOM   5171 C CD1 . LEU B 1 287 ? 4.876   -15.701 44.730 1.00 82.08  ? 313 LEU B CD1 1 
ATOM   5172 C CD2 . LEU B 1 287 ? 6.801   -17.316 44.551 1.00 73.22  ? 313 LEU B CD2 1 
ATOM   5173 N N   . CYS B 1 288 ? 4.796   -13.039 42.527 1.00 89.18  ? 314 CYS B N   1 
ATOM   5174 C CA  . CYS B 1 288 ? 5.225   -11.648 42.573 1.00 92.94  ? 314 CYS B CA  1 
ATOM   5175 C C   . CYS B 1 288 ? 4.612   -10.982 43.799 1.00 93.01  ? 314 CYS B C   1 
ATOM   5176 O O   . CYS B 1 288 ? 3.393   -11.027 43.984 1.00 93.49  ? 314 CYS B O   1 
ATOM   5177 C CB  . CYS B 1 288 ? 4.822   -10.935 41.267 1.00 93.27  ? 314 CYS B CB  1 
ATOM   5178 S SG  . CYS B 1 288 ? 4.845   -9.122  41.256 1.00 111.31 ? 314 CYS B SG  1 
ATOM   5179 N N   . PHE B 1 289 ? 5.455   -10.379 44.643 1.00 94.57  ? 315 PHE B N   1 
ATOM   5180 C CA  . PHE B 1 289 ? 4.913   -9.726  45.835 1.00 96.40  ? 315 PHE B CA  1 
ATOM   5181 C C   . PHE B 1 289 ? 4.521   -8.281  45.538 1.00 97.95  ? 315 PHE B C   1 
ATOM   5182 O O   . PHE B 1 289 ? 5.268   -7.567  44.861 1.00 100.78 ? 315 PHE B O   1 
ATOM   5183 C CB  . PHE B 1 289 ? 5.929   -9.737  46.968 1.00 94.20  ? 315 PHE B CB  1 
ATOM   5184 C CG  . PHE B 1 289 ? 6.259   -11.104 47.465 1.00 94.55  ? 315 PHE B CG  1 
ATOM   5185 C CD1 . PHE B 1 289 ? 7.278   -11.843 46.875 1.00 95.02  ? 315 PHE B CD1 1 
ATOM   5186 C CD2 . PHE B 1 289 ? 5.548   -11.657 48.522 1.00 89.26  ? 315 PHE B CD2 1 
ATOM   5187 C CE1 . PHE B 1 289 ? 7.588   -13.110 47.336 1.00 94.03  ? 315 PHE B CE1 1 
ATOM   5188 C CE2 . PHE B 1 289 ? 5.853   -12.919 48.990 1.00 83.53  ? 315 PHE B CE2 1 
ATOM   5189 C CZ  . PHE B 1 289 ? 6.873   -13.650 48.398 1.00 88.43  ? 315 PHE B CZ  1 
ATOM   5190 N N   . PRO B 1 290 ? 3.366   -7.826  46.039 1.00 98.17  ? 316 PRO B N   1 
ATOM   5191 C CA  . PRO B 1 290 ? 2.992   -6.416  45.859 1.00 99.59  ? 316 PRO B CA  1 
ATOM   5192 C C   . PRO B 1 290 ? 4.020   -5.490  46.497 1.00 105.27 ? 316 PRO B C   1 
ATOM   5193 O O   . PRO B 1 290 ? 4.557   -5.772  47.570 1.00 108.27 ? 316 PRO B O   1 
ATOM   5194 C CB  . PRO B 1 290 ? 1.627   -6.316  46.549 1.00 97.68  ? 316 PRO B CB  1 
ATOM   5195 C CG  . PRO B 1 290 ? 1.099   -7.719  46.556 1.00 91.90  ? 316 PRO B CG  1 
ATOM   5196 C CD  . PRO B 1 290 ? 2.316   -8.585  46.739 1.00 93.92  ? 316 PRO B CD  1 
ATOM   5197 N N   . GLU B 1 291 ? 4.304   -4.379  45.811 1.00 108.33 ? 317 GLU B N   1 
ATOM   5198 C CA  . GLU B 1 291 ? 5.341   -3.466  46.284 1.00 109.74 ? 317 GLU B CA  1 
ATOM   5199 C C   . GLU B 1 291 ? 4.989   -2.857  47.634 1.00 113.14 ? 317 GLU B C   1 
ATOM   5200 O O   . GLU B 1 291 ? 5.884   -2.617  48.454 1.00 116.44 ? 317 GLU B O   1 
ATOM   5201 C CB  . GLU B 1 291 ? 5.584   -2.364  45.249 1.00 114.91 ? 317 GLU B CB  1 
ATOM   5202 N N   . ASP B 1 292 ? 3.698   -2.613  47.885 1.00 115.62 ? 318 ASP B N   1 
ATOM   5203 C CA  . ASP B 1 292 ? 3.186   -1.998  49.110 1.00 114.73 ? 318 ASP B CA  1 
ATOM   5204 C C   . ASP B 1 292 ? 3.024   -2.979  50.276 1.00 114.15 ? 318 ASP B C   1 
ATOM   5205 O O   . ASP B 1 292 ? 2.495   -2.588  51.325 1.00 113.58 ? 318 ASP B O   1 
ATOM   5206 C CB  . ASP B 1 292 ? 1.844   -1.311  48.822 1.00 111.01 ? 318 ASP B CB  1 
ATOM   5207 N N   . ALA B 1 293 ? 3.451   -4.228  50.119 1.00 112.18 ? 319 ALA B N   1 
ATOM   5208 C CA  . ALA B 1 293 ? 3.293   -5.251  51.149 1.00 111.29 ? 319 ALA B CA  1 
ATOM   5209 C C   . ALA B 1 293 ? 4.431   -5.172  52.160 1.00 108.51 ? 319 ALA B C   1 
ATOM   5210 O O   . ALA B 1 293 ? 5.590   -5.449  51.831 1.00 105.50 ? 319 ALA B O   1 
ATOM   5211 C CB  . ALA B 1 293 ? 3.238   -6.636  50.513 1.00 109.27 ? 319 ALA B CB  1 
ATOM   5212 N N   . GLU B 1 294 ? 4.104   -4.818  53.400 1.00 109.53 ? 320 GLU B N   1 
ATOM   5213 C CA  . GLU B 1 294 ? 5.125   -4.771  54.444 1.00 107.31 ? 320 GLU B CA  1 
ATOM   5214 C C   . GLU B 1 294 ? 5.310   -6.172  55.050 1.00 103.52 ? 320 GLU B C   1 
ATOM   5215 O O   . GLU B 1 294 ? 5.022   -6.424  56.228 1.00 107.46 ? 320 GLU B O   1 
ATOM   5216 C CB  . GLU B 1 294 ? 4.745   -3.742  55.503 1.00 103.64 ? 320 GLU B CB  1 
ATOM   5217 N N   . ILE B 1 295 ? 5.844   -7.081  54.209 1.00 100.64 ? 321 ILE B N   1 
ATOM   5218 C CA  . ILE B 1 295 ? 6.261   -8.438  54.586 1.00 94.62  ? 321 ILE B CA  1 
ATOM   5219 C C   . ILE B 1 295 ? 7.761   -8.484  54.824 1.00 94.40  ? 321 ILE B C   1 
ATOM   5220 O O   . ILE B 1 295 ? 8.547   -7.978  54.013 1.00 96.16  ? 321 ILE B O   1 
ATOM   5221 C CB  . ILE B 1 295 ? 5.873   -9.551  53.573 1.00 92.64  ? 321 ILE B CB  1 
ATOM   5222 C CG1 . ILE B 1 295 ? 4.376   -9.606  53.256 1.00 93.99  ? 321 ILE B CG1 1 
ATOM   5223 C CG2 . ILE B 1 295 ? 6.543   -10.912 53.935 1.00 87.98  ? 321 ILE B CG2 1 
ATOM   5224 C CD1 . ILE B 1 295 ? 3.889   -8.700  52.185 1.00 100.97 ? 321 ILE B CD1 1 
ATOM   5225 N N   . SER B 1 296 ? 8.138   -9.095  55.953 1.00 90.23  ? 322 SER B N   1 
ATOM   5226 C CA  . SER B 1 296 ? 9.515   -9.309  56.366 1.00 88.70  ? 322 SER B CA  1 
ATOM   5227 C C   . SER B 1 296 ? 10.282  -10.140 55.344 1.00 87.52  ? 322 SER B C   1 
ATOM   5228 O O   . SER B 1 296 ? 9.727   -10.775 54.454 1.00 86.45  ? 322 SER B O   1 
ATOM   5229 C CB  . SER B 1 296 ? 9.568   -10.040 57.705 1.00 88.25  ? 322 SER B CB  1 
ATOM   5230 O OG  . SER B 1 296 ? 9.792   -11.443 57.490 1.00 86.25  ? 322 SER B OG  1 
ATOM   5231 N N   . LYS B 1 297 ? 11.590  -10.174 55.533 1.00 87.85  ? 323 LYS B N   1 
ATOM   5232 C CA  . LYS B 1 297 ? 12.489  -10.752 54.543 1.00 89.03  ? 323 LYS B CA  1 
ATOM   5233 C C   . LYS B 1 297 ? 12.800  -12.200 54.871 1.00 83.13  ? 323 LYS B C   1 
ATOM   5234 O O   . LYS B 1 297 ? 13.247  -12.954 53.999 1.00 83.27  ? 323 LYS B O   1 
ATOM   5235 C CB  . LYS B 1 297 ? 13.760  -9.910  54.506 1.00 94.98  ? 323 LYS B CB  1 
ATOM   5236 C CG  . LYS B 1 297 ? 13.433  -8.452  54.859 1.00 102.11 ? 323 LYS B CG  1 
ATOM   5237 C CD  . LYS B 1 297 ? 13.722  -8.333  56.363 1.00 98.66  ? 323 LYS B CD  1 
ATOM   5238 C CE  . LYS B 1 297 ? 13.034  -7.157  57.035 1.00 101.00 ? 323 LYS B CE  1 
ATOM   5239 N NZ  . LYS B 1 297 ? 13.347  -7.098  58.508 1.00 99.97  ? 323 LYS B NZ  1 
ATOM   5240 N N   . HIS B 1 298 ? 12.560  -12.596 56.126 1.00 87.74  ? 324 HIS B N   1 
ATOM   5241 C CA  . HIS B 1 298 ? 12.506  -14.005 56.470 1.00 84.00  ? 324 HIS B CA  1 
ATOM   5242 C C   . HIS B 1 298 ? 11.199  -14.624 55.995 1.00 76.54  ? 324 HIS B C   1 
ATOM   5243 O O   . HIS B 1 298 ? 11.184  -15.758 55.503 1.00 74.14  ? 324 HIS B O   1 
ATOM   5244 C CB  . HIS B 1 298 ? 12.644  -14.172 57.977 1.00 81.38  ? 324 HIS B CB  1 
ATOM   5245 C CG  . HIS B 1 298 ? 14.050  -14.073 58.496 1.00 87.75  ? 324 HIS B CG  1 
ATOM   5246 N ND1 . HIS B 1 298 ? 15.149  -14.408 57.736 1.00 85.76  ? 324 HIS B ND1 1 
ATOM   5247 C CD2 . HIS B 1 298 ? 14.533  -13.706 59.712 1.00 85.69  ? 324 HIS B CD2 1 
ATOM   5248 C CE1 . HIS B 1 298 ? 16.248  -14.243 58.451 1.00 86.21  ? 324 HIS B CE1 1 
ATOM   5249 N NE2 . HIS B 1 298 ? 15.903  -13.821 59.655 1.00 88.91  ? 324 HIS B NE2 1 
ATOM   5250 N N   . ALA B 1 299 ? 10.100  -13.882 56.112 1.00 76.87  ? 325 ALA B N   1 
ATOM   5251 C CA  . ALA B 1 299 ? 8.825   -14.408 55.650 1.00 77.87  ? 325 ALA B CA  1 
ATOM   5252 C C   . ALA B 1 299 ? 8.852   -14.601 54.138 1.00 81.36  ? 325 ALA B C   1 
ATOM   5253 O O   . ALA B 1 299 ? 8.540   -15.690 53.634 1.00 80.41  ? 325 ALA B O   1 
ATOM   5254 C CB  . ALA B 1 299 ? 7.689   -13.480 56.079 1.00 73.09  ? 325 ALA B CB  1 
ATOM   5255 N N   . LYS B 1 300 ? 9.280   -13.569 53.399 1.00 81.18  ? 326 LYS B N   1 
ATOM   5256 C CA  . LYS B 1 300 ? 9.422   -13.709 51.953 1.00 80.51  ? 326 LYS B CA  1 
ATOM   5257 C C   . LYS B 1 300 ? 10.375  -14.851 51.608 1.00 76.29  ? 326 LYS B C   1 
ATOM   5258 O O   . LYS B 1 300 ? 10.117  -15.631 50.683 1.00 73.46  ? 326 LYS B O   1 
ATOM   5259 C CB  . LYS B 1 300 ? 9.895   -12.391 51.337 1.00 84.26  ? 326 LYS B CB  1 
ATOM   5260 N N   . ASN B 1 301 ? 11.449  -15.012 52.375 1.00 73.63  ? 327 ASN B N   1 
ATOM   5261 C CA  . ASN B 1 301 ? 12.351  -16.121 52.086 1.00 74.07  ? 327 ASN B CA  1 
ATOM   5262 C C   . ASN B 1 301 ? 11.641  -17.461 52.252 1.00 77.22  ? 327 ASN B C   1 
ATOM   5263 O O   . ASN B 1 301 ? 11.776  -18.350 51.400 1.00 74.84  ? 327 ASN B O   1 
ATOM   5264 C CB  . ASN B 1 301 ? 13.579  -16.061 52.986 1.00 73.36  ? 327 ASN B CB  1 
ATOM   5265 C CG  . ASN B 1 301 ? 14.627  -17.098 52.607 1.00 76.15  ? 327 ASN B CG  1 
ATOM   5266 O OD1 . ASN B 1 301 ? 14.453  -18.301 52.840 1.00 73.92  ? 327 ASN B OD1 1 
ATOM   5267 N ND2 . ASN B 1 301 ? 15.725  -16.636 52.019 1.00 78.95  ? 327 ASN B ND2 1 
ATOM   5268 N N   . LEU B 1 302 ? 10.861  -17.620 53.332 1.00 74.52  ? 328 LEU B N   1 
ATOM   5269 C CA  . LEU B 1 302 ? 10.187  -18.897 53.553 1.00 73.52  ? 328 LEU B CA  1 
ATOM   5270 C C   . LEU B 1 302 ? 9.142   -19.158 52.474 1.00 69.34  ? 328 LEU B C   1 
ATOM   5271 O O   . LEU B 1 302 ? 9.058   -20.276 51.949 1.00 66.98  ? 328 LEU B O   1 
ATOM   5272 C CB  . LEU B 1 302 ? 9.548   -18.937 54.946 1.00 70.39  ? 328 LEU B CB  1 
ATOM   5273 C CG  . LEU B 1 302 ? 8.730   -20.194 55.264 1.00 66.83  ? 328 LEU B CG  1 
ATOM   5274 C CD1 . LEU B 1 302 ? 9.577   -21.427 55.132 1.00 68.90  ? 328 LEU B CD1 1 
ATOM   5275 C CD2 . LEU B 1 302 ? 8.164   -20.118 56.662 1.00 65.99  ? 328 LEU B CD2 1 
ATOM   5276 N N   . ILE B 1 303 ? 8.353   -18.139 52.119 1.00 68.17  ? 329 ILE B N   1 
ATOM   5277 C CA  . ILE B 1 303 ? 7.349   -18.307 51.068 1.00 70.99  ? 329 ILE B CA  1 
ATOM   5278 C C   . ILE B 1 303 ? 7.994   -18.811 49.786 1.00 68.41  ? 329 ILE B C   1 
ATOM   5279 O O   . ILE B 1 303 ? 7.552   -19.804 49.193 1.00 67.96  ? 329 ILE B O   1 
ATOM   5280 C CB  . ILE B 1 303 ? 6.590   -16.996 50.815 1.00 71.99  ? 329 ILE B CB  1 
ATOM   5281 C CG1 . ILE B 1 303 ? 5.738   -16.617 52.023 1.00 69.96  ? 329 ILE B CG1 1 
ATOM   5282 C CG2 . ILE B 1 303 ? 5.727   -17.151 49.567 1.00 71.24  ? 329 ILE B CG2 1 
ATOM   5283 C CD1 . ILE B 1 303 ? 5.086   -15.246 51.902 1.00 73.65  ? 329 ILE B CD1 1 
ATOM   5284 N N   . CYS B 1 304 ? 9.079   -18.164 49.357 1.00 75.19  ? 330 CYS B N   1 
ATOM   5285 C CA  . CYS B 1 304 ? 9.658   -18.562 48.084 1.00 72.11  ? 330 CYS B CA  1 
ATOM   5286 C C   . CYS B 1 304 ? 10.442  -19.854 48.198 1.00 69.89  ? 330 CYS B C   1 
ATOM   5287 O O   . CYS B 1 304 ? 10.656  -20.509 47.179 1.00 75.93  ? 330 CYS B O   1 
ATOM   5288 C CB  . CYS B 1 304 ? 10.593  -17.469 47.531 1.00 73.68  ? 330 CYS B CB  1 
ATOM   5289 S SG  . CYS B 1 304 ? 9.900   -15.769 47.386 1.00 84.08  ? 330 CYS B SG  1 
ATOM   5290 N N   . ALA B 1 305 ? 10.773  -20.300 49.411 1.00 67.85  ? 331 ALA B N   1 
ATOM   5291 C CA  . ALA B 1 305 ? 11.392  -21.616 49.555 1.00 70.68  ? 331 ALA B CA  1 
ATOM   5292 C C   . ALA B 1 305 ? 10.379  -22.750 49.383 1.00 73.12  ? 331 ALA B C   1 
ATOM   5293 O O   . ALA B 1 305 ? 10.757  -23.873 49.002 1.00 66.50  ? 331 ALA B O   1 
ATOM   5294 C CB  . ALA B 1 305 ? 12.090  -21.704 50.918 1.00 70.88  ? 331 ALA B CB  1 
ATOM   5295 N N   . PHE B 1 306 ? 9.097   -22.473 49.664 1.00 70.05  ? 332 PHE B N   1 
ATOM   5296 C CA  . PHE B 1 306 ? 7.993   -23.421 49.512 1.00 70.53  ? 332 PHE B CA  1 
ATOM   5297 C C   . PHE B 1 306 ? 7.439   -23.421 48.088 1.00 71.25  ? 332 PHE B C   1 
ATOM   5298 O O   . PHE B 1 306 ? 7.108   -24.483 47.545 1.00 71.22  ? 332 PHE B O   1 
ATOM   5299 C CB  . PHE B 1 306 ? 6.851   -23.074 50.491 1.00 67.39  ? 332 PHE B CB  1 
ATOM   5300 C CG  . PHE B 1 306 ? 7.003   -23.668 51.882 1.00 66.47  ? 332 PHE B CG  1 
ATOM   5301 C CD1 . PHE B 1 306 ? 7.452   -24.972 52.064 1.00 69.44  ? 332 PHE B CD1 1 
ATOM   5302 C CD2 . PHE B 1 306 ? 6.658   -22.924 53.007 1.00 65.48  ? 332 PHE B CD2 1 
ATOM   5303 C CE1 . PHE B 1 306 ? 7.576   -25.511 53.343 1.00 67.10  ? 332 PHE B CE1 1 
ATOM   5304 C CE2 . PHE B 1 306 ? 6.784   -23.463 54.286 1.00 66.98  ? 332 PHE B CE2 1 
ATOM   5305 C CZ  . PHE B 1 306 ? 7.244   -24.756 54.447 1.00 64.35  ? 332 PHE B CZ  1 
ATOM   5306 N N   . LEU B 1 307 ? 7.318   -22.238 47.482 1.00 70.63  ? 333 LEU B N   1 
ATOM   5307 C CA  . LEU B 1 307 ? 6.734   -22.085 46.147 1.00 68.86  ? 333 LEU B CA  1 
ATOM   5308 C C   . LEU B 1 307 ? 7.823   -22.208 45.073 1.00 73.42  ? 333 LEU B C   1 
ATOM   5309 O O   . LEU B 1 307 ? 8.093   -21.296 44.296 1.00 73.56  ? 333 LEU B O   1 
ATOM   5310 C CB  . LEU B 1 307 ? 5.981   -20.759 46.059 1.00 67.80  ? 333 LEU B CB  1 
ATOM   5311 C CG  . LEU B 1 307 ? 4.826   -20.556 47.065 1.00 65.92  ? 333 LEU B CG  1 
ATOM   5312 C CD1 . LEU B 1 307 ? 4.100   -19.254 46.824 1.00 66.38  ? 333 LEU B CD1 1 
ATOM   5313 C CD2 . LEU B 1 307 ? 3.838   -21.717 47.055 1.00 60.53  ? 333 LEU B CD2 1 
ATOM   5314 N N   . THR B 1 308 ? 8.482   -23.363 45.076 1.00 75.83  ? 334 THR B N   1 
ATOM   5315 C CA  . THR B 1 308 ? 9.435   -23.771 44.052 1.00 77.43  ? 334 THR B CA  1 
ATOM   5316 C C   . THR B 1 308 ? 9.009   -25.123 43.523 1.00 78.56  ? 334 THR B C   1 
ATOM   5317 O O   . THR B 1 308 ? 8.011   -25.701 43.962 1.00 71.40  ? 334 THR B O   1 
ATOM   5318 C CB  . THR B 1 308 ? 10.860  -23.918 44.597 1.00 78.05  ? 334 THR B CB  1 
ATOM   5319 O OG1 . THR B 1 308 ? 10.967  -25.163 45.299 1.00 80.88  ? 334 THR B OG1 1 
ATOM   5320 C CG2 . THR B 1 308 ? 11.195  -22.834 45.564 1.00 74.18  ? 334 THR B CG2 1 
ATOM   5321 N N   . ASP B 1 309 ? 9.798   -25.649 42.598 1.00 78.49  ? 335 ASP B N   1 
ATOM   5322 C CA  . ASP B 1 309 ? 9.533   -26.995 42.131 1.00 77.22  ? 335 ASP B CA  1 
ATOM   5323 C C   . ASP B 1 309 ? 9.981   -27.992 43.185 1.00 79.86  ? 335 ASP B C   1 
ATOM   5324 O O   . ASP B 1 309 ? 10.864  -27.709 44.007 1.00 79.23  ? 335 ASP B O   1 
ATOM   5325 C CB  . ASP B 1 309 ? 10.215  -27.250 40.789 1.00 84.43  ? 335 ASP B CB  1 
ATOM   5326 C CG  . ASP B 1 309 ? 9.782   -26.247 39.739 1.00 93.10  ? 335 ASP B CG  1 
ATOM   5327 O OD1 . ASP B 1 309 ? 8.691   -26.437 39.135 1.00 86.55  ? 335 ASP B OD1 1 
ATOM   5328 O OD2 . ASP B 1 309 ? 10.520  -25.246 39.556 1.00 99.76  ? 335 ASP B OD2 1 
ATOM   5329 N N   . ARG B 1 310 ? 9.353   -29.169 43.148 1.00 76.37  ? 336 ARG B N   1 
ATOM   5330 C CA  . ARG B 1 310 ? 9.507   -30.153 44.208 1.00 77.90  ? 336 ARG B CA  1 
ATOM   5331 C C   . ARG B 1 310 ? 10.964  -30.530 44.431 1.00 85.83  ? 336 ARG B C   1 
ATOM   5332 O O   . ARG B 1 310 ? 11.349  -30.868 45.559 1.00 85.06  ? 336 ARG B O   1 
ATOM   5333 C CB  . ARG B 1 310 ? 8.689   -31.392 43.862 1.00 81.30  ? 336 ARG B CB  1 
ATOM   5334 C CG  . ARG B 1 310 ? 9.122   -31.998 42.566 1.00 82.32  ? 336 ARG B CG  1 
ATOM   5335 C CD  . ARG B 1 310 ? 8.004   -32.709 41.870 1.00 85.84  ? 336 ARG B CD  1 
ATOM   5336 N NE  . ARG B 1 310 ? 7.800   -34.055 42.381 1.00 91.38  ? 336 ARG B NE  1 
ATOM   5337 C CZ  . ARG B 1 310 ? 7.428   -35.075 41.614 1.00 96.50  ? 336 ARG B CZ  1 
ATOM   5338 N NH1 . ARG B 1 310 ? 7.249   -36.283 42.140 1.00 99.80  ? 336 ARG B NH1 1 
ATOM   5339 N NH2 . ARG B 1 310 ? 7.257   -34.887 40.306 1.00 98.37  ? 336 ARG B NH2 1 
ATOM   5340 N N   . GLU B 1 311 ? 11.783  -30.466 43.376 1.00 80.48  ? 337 GLU B N   1 
ATOM   5341 C CA  . GLU B 1 311 ? 13.159  -30.942 43.461 1.00 83.16  ? 337 GLU B CA  1 
ATOM   5342 C C   . GLU B 1 311 ? 13.988  -30.127 44.451 1.00 87.42  ? 337 GLU B C   1 
ATOM   5343 O O   . GLU B 1 311 ? 14.876  -30.682 45.111 1.00 86.29  ? 337 GLU B O   1 
ATOM   5344 C CB  . GLU B 1 311 ? 13.799  -30.923 42.068 1.00 87.98  ? 337 GLU B CB  1 
ATOM   5345 N N   . VAL B 1 312 ? 13.701  -28.827 44.592 1.00 84.77  ? 338 VAL B N   1 
ATOM   5346 C CA  . VAL B 1 312 ? 14.404  -27.956 45.527 1.00 83.16  ? 338 VAL B CA  1 
ATOM   5347 C C   . VAL B 1 312 ? 13.463  -27.339 46.565 1.00 81.34  ? 338 VAL B C   1 
ATOM   5348 O O   . VAL B 1 312 ? 13.792  -26.316 47.163 1.00 78.81  ? 338 VAL B O   1 
ATOM   5349 C CB  . VAL B 1 312 ? 15.168  -26.849 44.781 1.00 83.32  ? 338 VAL B CB  1 
ATOM   5350 C CG1 . VAL B 1 312 ? 16.190  -27.459 43.838 1.00 84.00  ? 338 VAL B CG1 1 
ATOM   5351 C CG2 . VAL B 1 312 ? 14.182  -25.957 44.043 1.00 80.54  ? 338 VAL B CG2 1 
ATOM   5352 N N   . ARG B 1 313 ? 12.294  -27.934 46.792 1.00 79.67  ? 339 ARG B N   1 
ATOM   5353 C CA  . ARG B 1 313 ? 11.325  -27.321 47.693 1.00 81.84  ? 339 ARG B CA  1 
ATOM   5354 C C   . ARG B 1 313 ? 11.735  -27.550 49.147 1.00 78.94  ? 339 ARG B C   1 
ATOM   5355 O O   . ARG B 1 313 ? 12.161  -28.647 49.526 1.00 79.81  ? 339 ARG B O   1 
ATOM   5356 C CB  . ARG B 1 313 ? 9.916   -27.876 47.445 1.00 78.19  ? 339 ARG B CB  1 
ATOM   5357 C CG  . ARG B 1 313 ? 8.793   -27.090 48.158 1.00 75.28  ? 339 ARG B CG  1 
ATOM   5358 C CD  . ARG B 1 313 ? 7.385   -27.620 47.792 1.00 75.87  ? 339 ARG B CD  1 
ATOM   5359 N NE  . ARG B 1 313 ? 7.138   -27.523 46.344 1.00 71.41  ? 339 ARG B NE  1 
ATOM   5360 C CZ  . ARG B 1 313 ? 6.426   -28.394 45.632 1.00 69.70  ? 339 ARG B CZ  1 
ATOM   5361 N NH1 . ARG B 1 313 ? 5.851   -29.439 46.219 1.00 67.82  ? 339 ARG B NH1 1 
ATOM   5362 N NH2 . ARG B 1 313 ? 6.295   -28.228 44.320 1.00 71.01  ? 339 ARG B NH2 1 
ATOM   5363 N N   . LEU B 1 314 ? 11.651  -26.493 49.952 1.00 71.44  ? 340 LEU B N   1 
ATOM   5364 C CA  . LEU B 1 314 ? 11.837  -26.655 51.386 1.00 75.82  ? 340 LEU B CA  1 
ATOM   5365 C C   . LEU B 1 314 ? 10.929  -27.761 51.922 1.00 80.33  ? 340 LEU B C   1 
ATOM   5366 O O   . LEU B 1 314 ? 9.710   -27.748 51.714 1.00 77.54  ? 340 LEU B O   1 
ATOM   5367 C CB  . LEU B 1 314 ? 11.556  -25.339 52.111 1.00 72.21  ? 340 LEU B CB  1 
ATOM   5368 C CG  . LEU B 1 314 ? 11.824  -25.459 53.615 1.00 73.42  ? 340 LEU B CG  1 
ATOM   5369 C CD1 . LEU B 1 314 ? 13.209  -26.017 53.852 1.00 75.66  ? 340 LEU B CD1 1 
ATOM   5370 C CD2 . LEU B 1 314 ? 11.687  -24.121 54.324 1.00 71.32  ? 340 LEU B CD2 1 
ATOM   5371 N N   . GLY B 1 315 ? 11.537  -28.725 52.612 1.00 81.52  ? 341 GLY B N   1 
ATOM   5372 C CA  . GLY B 1 315 ? 10.853  -29.905 53.103 1.00 74.50  ? 341 GLY B CA  1 
ATOM   5373 C C   . GLY B 1 315 ? 11.167  -31.175 52.341 1.00 77.56  ? 341 GLY B C   1 
ATOM   5374 O O   . GLY B 1 315 ? 10.810  -32.261 52.814 1.00 77.19  ? 341 GLY B O   1 
ATOM   5375 N N   . ARG B 1 316 ? 11.833  -31.084 51.185 1.00 79.52  ? 342 ARG B N   1 
ATOM   5376 C CA  . ARG B 1 316 ? 12.182  -32.292 50.434 1.00 87.28  ? 342 ARG B CA  1 
ATOM   5377 C C   . ARG B 1 316 ? 13.060  -33.244 51.250 1.00 89.22  ? 342 ARG B C   1 
ATOM   5378 O O   . ARG B 1 316 ? 12.922  -34.469 51.139 1.00 90.89  ? 342 ARG B O   1 
ATOM   5379 C CB  . ARG B 1 316 ? 12.871  -31.904 49.120 1.00 88.40  ? 342 ARG B CB  1 
ATOM   5380 C CG  . ARG B 1 316 ? 13.207  -33.077 48.201 1.00 93.54  ? 342 ARG B CG  1 
ATOM   5381 C CD  . ARG B 1 316 ? 11.963  -33.833 47.736 1.00 94.55  ? 342 ARG B CD  1 
ATOM   5382 N NE  . ARG B 1 316 ? 12.299  -34.941 46.838 1.00 100.05 ? 342 ARG B NE  1 
ATOM   5383 C CZ  . ARG B 1 316 ? 12.044  -34.952 45.530 1.00 104.56 ? 342 ARG B CZ  1 
ATOM   5384 N NH1 . ARG B 1 316 ? 12.381  -36.003 44.788 1.00 106.59 ? 342 ARG B NH1 1 
ATOM   5385 N NH2 . ARG B 1 316 ? 11.447  -33.911 44.960 1.00 106.35 ? 342 ARG B NH2 1 
ATOM   5386 N N   . ASN B 1 317 ? 13.923  -32.704 52.111 1.00 87.33  ? 343 ASN B N   1 
ATOM   5387 C CA  . ASN B 1 317 ? 14.873  -33.481 52.897 1.00 89.44  ? 343 ASN B CA  1 
ATOM   5388 C C   . ASN B 1 317 ? 14.348  -33.832 54.283 1.00 90.65  ? 343 ASN B C   1 
ATOM   5389 O O   . ASN B 1 317 ? 15.144  -34.124 55.185 1.00 88.06  ? 343 ASN B O   1 
ATOM   5390 C CB  . ASN B 1 317 ? 16.196  -32.728 53.028 1.00 88.73  ? 343 ASN B CB  1 
ATOM   5391 C CG  . ASN B 1 317 ? 16.912  -32.598 51.713 1.00 95.11  ? 343 ASN B CG  1 
ATOM   5392 O OD1 . ASN B 1 317 ? 17.308  -31.501 51.307 1.00 99.21  ? 343 ASN B OD1 1 
ATOM   5393 N ND2 . ASN B 1 317 ? 17.061  -33.720 51.018 1.00 94.88  ? 343 ASN B ND2 1 
ATOM   5394 N N   . GLY B 1 318 ? 13.052  -33.706 54.503 1.00 89.07  ? 344 GLY B N   1 
ATOM   5395 C CA  . GLY B 1 318 ? 12.488  -33.973 55.805 1.00 83.87  ? 344 GLY B CA  1 
ATOM   5396 C C   . GLY B 1 318 ? 11.943  -32.708 56.436 1.00 79.63  ? 344 GLY B C   1 
ATOM   5397 O O   . GLY B 1 318 ? 12.260  -31.585 56.036 1.00 79.81  ? 344 GLY B O   1 
ATOM   5398 N N   . VAL B 1 319 ? 11.149  -32.896 57.484 1.00 73.52  ? 345 VAL B N   1 
ATOM   5399 C CA  . VAL B 1 319 ? 10.478  -31.739 58.060 1.00 77.14  ? 345 VAL B CA  1 
ATOM   5400 C C   . VAL B 1 319 ? 11.403  -30.936 58.969 1.00 79.31  ? 345 VAL B C   1 
ATOM   5401 O O   . VAL B 1 319 ? 11.085  -29.781 59.300 1.00 77.12  ? 345 VAL B O   1 
ATOM   5402 C CB  . VAL B 1 319 ? 9.204   -32.284 58.742 1.00 79.67  ? 345 VAL B CB  1 
ATOM   5403 C CG1 . VAL B 1 319 ? 9.537   -33.467 59.649 1.00 80.26  ? 345 VAL B CG1 1 
ATOM   5404 C CG2 . VAL B 1 319 ? 8.461   -31.200 59.495 1.00 72.09  ? 345 VAL B CG2 1 
ATOM   5405 N N   . GLU B 1 320 ? 12.594  -31.465 59.289 1.00 75.44  ? 346 GLU B N   1 
ATOM   5406 C CA  . GLU B 1 320 ? 13.523  -30.738 60.156 1.00 75.11  ? 346 GLU B CA  1 
ATOM   5407 C C   . GLU B 1 320 ? 13.932  -29.391 59.568 1.00 73.45  ? 346 GLU B C   1 
ATOM   5408 O O   . GLU B 1 320 ? 14.001  -28.385 60.289 1.00 70.81  ? 346 GLU B O   1 
ATOM   5409 C CB  . GLU B 1 320 ? 14.766  -31.591 60.426 1.00 78.25  ? 346 GLU B CB  1 
ATOM   5410 N N   . GLU B 1 321 ? 14.165  -29.337 58.252 1.00 77.60  ? 347 GLU B N   1 
ATOM   5411 C CA  . GLU B 1 321 ? 14.644  -28.097 57.646 1.00 74.97  ? 347 GLU B CA  1 
ATOM   5412 C C   . GLU B 1 321 ? 13.558  -27.029 57.589 1.00 74.99  ? 347 GLU B C   1 
ATOM   5413 O O   . GLU B 1 321 ? 13.880  -25.840 57.477 1.00 73.09  ? 347 GLU B O   1 
ATOM   5414 C CB  . GLU B 1 321 ? 15.213  -28.366 56.243 1.00 75.00  ? 347 GLU B CB  1 
ATOM   5415 C CG  . GLU B 1 321 ? 14.272  -29.161 55.340 1.00 84.35  ? 347 GLU B CG  1 
ATOM   5416 C CD  . GLU B 1 321 ? 14.933  -29.628 54.052 1.00 92.37  ? 347 GLU B CD  1 
ATOM   5417 O OE1 . GLU B 1 321 ? 16.174  -29.773 54.041 1.00 97.64  ? 347 GLU B OE1 1 
ATOM   5418 O OE2 . GLU B 1 321 ? 14.211  -29.858 53.051 1.00 90.41  ? 347 GLU B OE2 1 
ATOM   5419 N N   . ILE B 1 322 ? 12.284  -27.413 57.653 1.00 71.16  ? 348 ILE B N   1 
ATOM   5420 C CA  . ILE B 1 322 ? 11.251  -26.398 57.811 1.00 71.26  ? 348 ILE B CA  1 
ATOM   5421 C C   . ILE B 1 322 ? 11.310  -25.794 59.208 1.00 71.81  ? 348 ILE B C   1 
ATOM   5422 O O   . ILE B 1 322 ? 11.199  -24.567 59.371 1.00 68.37  ? 348 ILE B O   1 
ATOM   5423 C CB  . ILE B 1 322 ? 9.867   -26.991 57.508 1.00 72.34  ? 348 ILE B CB  1 
ATOM   5424 C CG1 . ILE B 1 322 ? 9.832   -27.541 56.085 1.00 71.13  ? 348 ILE B CG1 1 
ATOM   5425 C CG2 . ILE B 1 322 ? 8.802   -25.931 57.705 1.00 65.02  ? 348 ILE B CG2 1 
ATOM   5426 C CD1 . ILE B 1 322 ? 8.661   -28.443 55.831 1.00 71.02  ? 348 ILE B CD1 1 
ATOM   5427 N N   . ARG B 1 323 ? 11.459  -26.646 60.241 1.00 69.10  ? 349 ARG B N   1 
ATOM   5428 C CA  . ARG B 1 323 ? 11.468  -26.165 61.626 1.00 72.95  ? 349 ARG B CA  1 
ATOM   5429 C C   . ARG B 1 323 ? 12.608  -25.186 61.870 1.00 68.77  ? 349 ARG B C   1 
ATOM   5430 O O   . ARG B 1 323 ? 12.459  -24.221 62.629 1.00 67.28  ? 349 ARG B O   1 
ATOM   5431 C CB  . ARG B 1 323 ? 11.598  -27.326 62.607 1.00 71.34  ? 349 ARG B CB  1 
ATOM   5432 C CG  . ARG B 1 323 ? 10.421  -28.268 62.696 1.00 71.71  ? 349 ARG B CG  1 
ATOM   5433 C CD  . ARG B 1 323 ? 10.680  -29.242 63.840 1.00 76.82  ? 349 ARG B CD  1 
ATOM   5434 N NE  . ARG B 1 323 ? 10.441  -30.629 63.455 1.00 85.83  ? 349 ARG B NE  1 
ATOM   5435 C CZ  . ARG B 1 323 ? 11.408  -31.506 63.187 1.00 87.19  ? 349 ARG B CZ  1 
ATOM   5436 N NH1 . ARG B 1 323 ? 12.685  -31.141 63.267 1.00 85.21  ? 349 ARG B NH1 1 
ATOM   5437 N NH2 . ARG B 1 323 ? 11.100  -32.755 62.845 1.00 88.26  ? 349 ARG B NH2 1 
ATOM   5438 N N   . GLN B 1 324 ? 13.769  -25.444 61.262 1.00 74.42  ? 350 GLN B N   1 
ATOM   5439 C CA  . GLN B 1 324 ? 14.972  -24.655 61.500 1.00 75.41  ? 350 GLN B CA  1 
ATOM   5440 C C   . GLN B 1 324 ? 14.964  -23.318 60.768 1.00 78.14  ? 350 GLN B C   1 
ATOM   5441 O O   . GLN B 1 324 ? 15.893  -22.528 60.959 1.00 75.59  ? 350 GLN B O   1 
ATOM   5442 C CB  . GLN B 1 324 ? 16.215  -25.459 61.078 1.00 72.01  ? 350 GLN B CB  1 
ATOM   5443 N N   . HIS B 1 325 ? 13.960  -23.043 59.931 1.00 76.33  ? 351 HIS B N   1 
ATOM   5444 C CA  . HIS B 1 325 ? 13.971  -21.810 59.150 1.00 76.05  ? 351 HIS B CA  1 
ATOM   5445 C C   . HIS B 1 325 ? 13.865  -20.590 60.061 1.00 76.40  ? 351 HIS B C   1 
ATOM   5446 O O   . HIS B 1 325 ? 12.985  -20.549 60.934 1.00 77.32  ? 351 HIS B O   1 
ATOM   5447 C CB  . HIS B 1 325 ? 12.850  -21.787 58.109 1.00 77.35  ? 351 HIS B CB  1 
ATOM   5448 C CG  . HIS B 1 325 ? 12.946  -20.627 57.169 1.00 73.99  ? 351 HIS B CG  1 
ATOM   5449 N ND1 . HIS B 1 325 ? 12.483  -19.369 57.492 1.00 75.13  ? 351 HIS B ND1 1 
ATOM   5450 C CD2 . HIS B 1 325 ? 13.497  -20.518 55.938 1.00 73.55  ? 351 HIS B CD2 1 
ATOM   5451 C CE1 . HIS B 1 325 ? 12.722  -18.541 56.491 1.00 72.77  ? 351 HIS B CE1 1 
ATOM   5452 N NE2 . HIS B 1 325 ? 13.333  -19.216 55.533 1.00 71.59  ? 351 HIS B NE2 1 
ATOM   5453 N N   . PRO B 1 326 ? 14.694  -19.559 59.846 1.00 79.58  ? 352 PRO B N   1 
ATOM   5454 C CA  . PRO B 1 326 ? 14.709  -18.405 60.763 1.00 73.74  ? 352 PRO B CA  1 
ATOM   5455 C C   . PRO B 1 326 ? 13.385  -17.691 60.910 1.00 75.43  ? 352 PRO B C   1 
ATOM   5456 O O   . PRO B 1 326 ? 13.224  -16.947 61.886 1.00 77.67  ? 352 PRO B O   1 
ATOM   5457 C CB  . PRO B 1 326 ? 15.762  -17.470 60.138 1.00 75.15  ? 352 PRO B CB  1 
ATOM   5458 C CG  . PRO B 1 326 ? 15.890  -17.919 58.712 1.00 74.77  ? 352 PRO B CG  1 
ATOM   5459 C CD  . PRO B 1 326 ? 15.674  -19.404 58.753 1.00 76.41  ? 352 PRO B CD  1 
ATOM   5460 N N   . PHE B 1 327 ? 12.451  -17.841 59.963 1.00 74.76  ? 353 PHE B N   1 
ATOM   5461 C CA  . PHE B 1 327 ? 11.141  -17.210 60.120 1.00 71.89  ? 353 PHE B CA  1 
ATOM   5462 C C   . PHE B 1 327 ? 10.479  -17.600 61.438 1.00 70.05  ? 353 PHE B C   1 
ATOM   5463 O O   . PHE B 1 327 ? 9.777   -16.786 62.050 1.00 66.48  ? 353 PHE B O   1 
ATOM   5464 C CB  . PHE B 1 327 ? 10.227  -17.584 58.948 1.00 70.97  ? 353 PHE B CB  1 
ATOM   5465 C CG  . PHE B 1 327 ? 8.813   -17.092 59.105 1.00 66.68  ? 353 PHE B CG  1 
ATOM   5466 C CD1 . PHE B 1 327 ? 8.539   -15.738 59.108 1.00 66.69  ? 353 PHE B CD1 1 
ATOM   5467 C CD2 . PHE B 1 327 ? 7.763   -17.985 59.270 1.00 67.85  ? 353 PHE B CD2 1 
ATOM   5468 C CE1 . PHE B 1 327 ? 7.244   -15.272 59.263 1.00 71.30  ? 353 PHE B CE1 1 
ATOM   5469 C CE2 . PHE B 1 327 ? 6.455   -17.531 59.414 1.00 66.04  ? 353 PHE B CE2 1 
ATOM   5470 C CZ  . PHE B 1 327 ? 6.197   -16.171 59.420 1.00 67.62  ? 353 PHE B CZ  1 
ATOM   5471 N N   . PHE B 1 328 ? 10.695  -18.834 61.888 1.00 69.48  ? 354 PHE B N   1 
ATOM   5472 C CA  . PHE B 1 328 ? 9.989   -19.387 63.034 1.00 74.66  ? 354 PHE B CA  1 
ATOM   5473 C C   . PHE B 1 328 ? 10.591  -19.004 64.385 1.00 77.41  ? 354 PHE B C   1 
ATOM   5474 O O   . PHE B 1 328 ? 10.055  -19.430 65.414 1.00 72.83  ? 354 PHE B O   1 
ATOM   5475 C CB  . PHE B 1 328 ? 9.943   -20.908 62.903 1.00 70.28  ? 354 PHE B CB  1 
ATOM   5476 C CG  . PHE B 1 328 ? 9.069   -21.391 61.776 1.00 74.13  ? 354 PHE B CG  1 
ATOM   5477 C CD1 . PHE B 1 328 ? 7.704   -21.111 61.767 1.00 73.68  ? 354 PHE B CD1 1 
ATOM   5478 C CD2 . PHE B 1 328 ? 9.603   -22.129 60.731 1.00 73.79  ? 354 PHE B CD2 1 
ATOM   5479 C CE1 . PHE B 1 328 ? 6.891   -21.555 60.727 1.00 69.40  ? 354 PHE B CE1 1 
ATOM   5480 C CE2 . PHE B 1 328 ? 8.796   -22.572 59.695 1.00 69.40  ? 354 PHE B CE2 1 
ATOM   5481 C CZ  . PHE B 1 328 ? 7.434   -22.283 59.700 1.00 63.24  ? 354 PHE B CZ  1 
ATOM   5482 N N   . LYS B 1 329 ? 11.646  -18.186 64.424 1.00 76.34  ? 355 LYS B N   1 
ATOM   5483 C CA  . LYS B 1 329 ? 12.230  -17.795 65.703 1.00 77.83  ? 355 LYS B CA  1 
ATOM   5484 C C   . LYS B 1 329 ? 11.284  -16.840 66.422 1.00 77.47  ? 355 LYS B C   1 
ATOM   5485 O O   . LYS B 1 329 ? 10.732  -15.915 65.816 1.00 77.42  ? 355 LYS B O   1 
ATOM   5486 C CB  . LYS B 1 329 ? 13.602  -17.147 65.496 1.00 73.06  ? 355 LYS B CB  1 
ATOM   5487 N N   . ASN B 1 330 ? 11.069  -17.088 67.710 1.00 74.62  ? 356 ASN B N   1 
ATOM   5488 C CA  . ASN B 1 330 ? 10.055  -16.368 68.471 1.00 77.19  ? 356 ASN B CA  1 
ATOM   5489 C C   . ASN B 1 330 ? 10.264  -16.666 69.951 1.00 79.82  ? 356 ASN B C   1 
ATOM   5490 O O   . ASN B 1 330 ? 11.065  -17.531 70.330 1.00 70.35  ? 356 ASN B O   1 
ATOM   5491 C CB  . ASN B 1 330 ? 8.640   -16.748 68.022 1.00 73.90  ? 356 ASN B CB  1 
ATOM   5492 C CG  . ASN B 1 330 ? 8.177   -18.067 68.620 1.00 74.05  ? 356 ASN B CG  1 
ATOM   5493 O OD1 . ASN B 1 330 ? 7.457   -18.086 69.619 1.00 76.75  ? 356 ASN B OD1 1 
ATOM   5494 N ND2 . ASN B 1 330 ? 8.599   -19.177 68.017 1.00 71.75  ? 356 ASN B ND2 1 
ATOM   5495 N N   . ASP B 1 331 ? 9.531   -15.930 70.786 1.00 80.50  ? 357 ASP B N   1 
ATOM   5496 C CA  . ASP B 1 331 ? 9.668   -16.031 72.232 1.00 85.27  ? 357 ASP B CA  1 
ATOM   5497 C C   . ASP B 1 331 ? 8.434   -16.595 72.926 1.00 85.19  ? 357 ASP B C   1 
ATOM   5498 O O   . ASP B 1 331 ? 8.342   -16.509 74.156 1.00 86.36  ? 357 ASP B O   1 
ATOM   5499 C CB  . ASP B 1 331 ? 10.034  -14.660 72.805 1.00 82.21  ? 357 ASP B CB  1 
ATOM   5500 C CG  . ASP B 1 331 ? 11.329  -14.136 72.221 1.00 91.93  ? 357 ASP B CG  1 
ATOM   5501 O OD1 . ASP B 1 331 ? 12.311  -14.915 72.191 1.00 92.36  ? 357 ASP B OD1 1 
ATOM   5502 O OD2 . ASP B 1 331 ? 11.361  -12.971 71.762 1.00 94.71  ? 357 ASP B OD2 1 
ATOM   5503 N N   . GLN B 1 332 ? 7.469   -17.144 72.185 1.00 78.61  ? 358 GLN B N   1 
ATOM   5504 C CA  . GLN B 1 332 ? 6.253   -17.636 72.820 1.00 78.31  ? 358 GLN B CA  1 
ATOM   5505 C C   . GLN B 1 332 ? 6.110   -19.146 72.792 1.00 74.64  ? 358 GLN B C   1 
ATOM   5506 O O   . GLN B 1 332 ? 5.416   -19.693 73.658 1.00 77.60  ? 358 GLN B O   1 
ATOM   5507 C CB  . GLN B 1 332 ? 5.004   -17.000 72.196 1.00 83.27  ? 358 GLN B CB  1 
ATOM   5508 C CG  . GLN B 1 332 ? 4.885   -15.539 72.544 1.00 86.50  ? 358 GLN B CG  1 
ATOM   5509 C CD  . GLN B 1 332 ? 5.750   -14.698 71.641 1.00 94.14  ? 358 GLN B CD  1 
ATOM   5510 O OE1 . GLN B 1 332 ? 5.617   -14.755 70.414 1.00 95.68  ? 358 GLN B OE1 1 
ATOM   5511 N NE2 . GLN B 1 332 ? 6.690   -13.956 72.234 1.00 95.35  ? 358 GLN B NE2 1 
ATOM   5512 N N   . TRP B 1 333 ? 6.751   -19.836 71.850 1.00 68.61  ? 359 TRP B N   1 
ATOM   5513 C CA  . TRP B 1 333 ? 6.532   -21.268 71.744 1.00 67.14  ? 359 TRP B CA  1 
ATOM   5514 C C   . TRP B 1 333 ? 7.774   -21.959 71.207 1.00 65.46  ? 359 TRP B C   1 
ATOM   5515 O O   . TRP B 1 333 ? 8.609   -21.353 70.540 1.00 64.13  ? 359 TRP B O   1 
ATOM   5516 C CB  . TRP B 1 333 ? 5.319   -21.581 70.853 1.00 67.58  ? 359 TRP B CB  1 
ATOM   5517 C CG  . TRP B 1 333 ? 5.377   -20.978 69.463 1.00 67.04  ? 359 TRP B CG  1 
ATOM   5518 C CD1 . TRP B 1 333 ? 4.775   -19.824 69.047 1.00 68.30  ? 359 TRP B CD1 1 
ATOM   5519 C CD2 . TRP B 1 333 ? 6.057   -21.511 68.313 1.00 64.42  ? 359 TRP B CD2 1 
ATOM   5520 N NE1 . TRP B 1 333 ? 5.048   -19.600 67.715 1.00 69.82  ? 359 TRP B NE1 1 
ATOM   5521 C CE2 . TRP B 1 333 ? 5.827   -20.624 67.243 1.00 65.71  ? 359 TRP B CE2 1 
ATOM   5522 C CE3 . TRP B 1 333 ? 6.840   -22.648 68.089 1.00 65.65  ? 359 TRP B CE3 1 
ATOM   5523 C CZ2 . TRP B 1 333 ? 6.345   -20.841 65.973 1.00 64.23  ? 359 TRP B CZ2 1 
ATOM   5524 C CZ3 . TRP B 1 333 ? 7.358   -22.859 66.833 1.00 67.51  ? 359 TRP B CZ3 1 
ATOM   5525 C CH2 . TRP B 1 333 ? 7.107   -21.961 65.787 1.00 67.68  ? 359 TRP B CH2 1 
ATOM   5526 N N   . HIS B 1 334 ? 7.863   -23.254 71.499 1.00 68.13  ? 360 HIS B N   1 
ATOM   5527 C CA  . HIS B 1 334 ? 8.829   -24.163 70.908 1.00 64.78  ? 360 HIS B CA  1 
ATOM   5528 C C   . HIS B 1 334 ? 8.079   -25.137 70.010 1.00 69.62  ? 360 HIS B C   1 
ATOM   5529 O O   . HIS B 1 334 ? 6.854   -25.292 70.113 1.00 70.54  ? 360 HIS B O   1 
ATOM   5530 C CB  . HIS B 1 334 ? 9.604   -24.939 71.983 1.00 68.10  ? 360 HIS B CB  1 
ATOM   5531 C CG  . HIS B 1 334 ? 10.395  -24.067 72.902 1.00 74.14  ? 360 HIS B CG  1 
ATOM   5532 N ND1 . HIS B 1 334 ? 9.818   -23.351 73.931 1.00 79.13  ? 360 HIS B ND1 1 
ATOM   5533 C CD2 . HIS B 1 334 ? 11.718  -23.787 72.944 1.00 75.73  ? 360 HIS B CD2 1 
ATOM   5534 C CE1 . HIS B 1 334 ? 10.752  -22.664 74.566 1.00 74.52  ? 360 HIS B CE1 1 
ATOM   5535 N NE2 . HIS B 1 334 ? 11.913  -22.911 73.986 1.00 76.01  ? 360 HIS B NE2 1 
ATOM   5536 N N   . TRP B 1 335 ? 8.820   -25.763 69.093 1.00 66.18  ? 361 TRP B N   1 
ATOM   5537 C CA  . TRP B 1 335 ? 8.206   -26.740 68.206 1.00 66.87  ? 361 TRP B CA  1 
ATOM   5538 C C   . TRP B 1 335 ? 7.620   -27.915 68.965 1.00 66.84  ? 361 TRP B C   1 
ATOM   5539 O O   . TRP B 1 335 ? 6.589   -28.463 68.562 1.00 70.72  ? 361 TRP B O   1 
ATOM   5540 C CB  . TRP B 1 335 ? 9.236   -27.251 67.211 1.00 64.76  ? 361 TRP B CB  1 
ATOM   5541 C CG  . TRP B 1 335 ? 9.408   -26.322 66.089 1.00 73.83  ? 361 TRP B CG  1 
ATOM   5542 C CD1 . TRP B 1 335 ? 10.412  -25.422 65.921 1.00 73.03  ? 361 TRP B CD1 1 
ATOM   5543 C CD2 . TRP B 1 335 ? 8.533   -26.170 64.967 1.00 69.67  ? 361 TRP B CD2 1 
ATOM   5544 N NE1 . TRP B 1 335 ? 10.229  -24.725 64.753 1.00 72.51  ? 361 TRP B NE1 1 
ATOM   5545 C CE2 . TRP B 1 335 ? 9.080   -25.164 64.149 1.00 73.58  ? 361 TRP B CE2 1 
ATOM   5546 C CE3 . TRP B 1 335 ? 7.351   -26.801 64.564 1.00 65.82  ? 361 TRP B CE3 1 
ATOM   5547 C CZ2 . TRP B 1 335 ? 8.482   -24.767 62.950 1.00 73.10  ? 361 TRP B CZ2 1 
ATOM   5548 C CZ3 . TRP B 1 335 ? 6.757   -26.405 63.368 1.00 68.26  ? 361 TRP B CZ3 1 
ATOM   5549 C CH2 . TRP B 1 335 ? 7.325   -25.403 62.578 1.00 68.87  ? 361 TRP B CH2 1 
ATOM   5550 N N   . ASP B 1 336 ? 8.243   -28.306 70.066 1.00 67.52  ? 362 ASP B N   1 
ATOM   5551 C CA  . ASP B 1 336 ? 7.790   -29.475 70.800 1.00 68.54  ? 362 ASP B CA  1 
ATOM   5552 C C   . ASP B 1 336 ? 6.625   -29.167 71.734 1.00 63.61  ? 362 ASP B C   1 
ATOM   5553 O O   . ASP B 1 336 ? 6.145   -30.088 72.402 1.00 65.06  ? 362 ASP B O   1 
ATOM   5554 C CB  . ASP B 1 336 ? 8.958   -30.139 71.558 1.00 69.69  ? 362 ASP B CB  1 
ATOM   5555 C CG  . ASP B 1 336 ? 9.750   -29.162 72.425 1.00 74.30  ? 362 ASP B CG  1 
ATOM   5556 O OD1 . ASP B 1 336 ? 9.166   -28.215 72.996 1.00 73.79  ? 362 ASP B OD1 1 
ATOM   5557 O OD2 . ASP B 1 336 ? 10.977  -29.360 72.551 1.00 84.54  ? 362 ASP B OD2 1 
ATOM   5558 N N   . ASN B 1 337 ? 6.215   -27.892 71.878 1.00 59.23  ? 363 ASN B N   1 
ATOM   5559 C CA  . ASN B 1 337 ? 5.212   -27.578 72.897 1.00 68.10  ? 363 ASN B CA  1 
ATOM   5560 C C   . ASN B 1 337 ? 4.136   -26.586 72.450 1.00 61.49  ? 363 ASN B C   1 
ATOM   5561 O O   . ASN B 1 337 ? 3.350   -26.134 73.296 1.00 64.33  ? 363 ASN B O   1 
ATOM   5562 C CB  . ASN B 1 337 ? 5.885   -27.051 74.196 1.00 58.51  ? 363 ASN B CB  1 
ATOM   5563 C CG  . ASN B 1 337 ? 6.119   -25.534 74.179 1.00 64.71  ? 363 ASN B CG  1 
ATOM   5564 O OD1 . ASN B 1 337 ? 6.318   -24.927 73.122 1.00 63.03  ? 363 ASN B OD1 1 
ATOM   5565 N ND2 . ASN B 1 337 ? 6.079   -24.913 75.368 1.00 62.18  ? 363 ASN B ND2 1 
ATOM   5566 N N   . ILE B 1 338 ? 4.051   -26.261 71.158 1.00 59.29  ? 364 ILE B N   1 
ATOM   5567 C CA  . ILE B 1 338 ? 3.220   -25.148 70.710 1.00 56.96  ? 364 ILE B CA  1 
ATOM   5568 C C   . ILE B 1 338 ? 1.756   -25.380 71.050 1.00 58.37  ? 364 ILE B C   1 
ATOM   5569 O O   . ILE B 1 338 ? 1.025   -24.432 71.378 1.00 58.03  ? 364 ILE B O   1 
ATOM   5570 C CB  . ILE B 1 338 ? 3.420   -24.922 69.196 1.00 59.90  ? 364 ILE B CB  1 
ATOM   5571 C CG1 . ILE B 1 338 ? 2.592   -23.729 68.716 1.00 60.83  ? 364 ILE B CG1 1 
ATOM   5572 C CG2 . ILE B 1 338 ? 3.108   -26.197 68.411 1.00 56.50  ? 364 ILE B CG2 1 
ATOM   5573 C CD1 . ILE B 1 338 ? 2.862   -23.337 67.283 1.00 60.12  ? 364 ILE B CD1 1 
ATOM   5574 N N   . ARG B 1 339 ? 1.301   -26.626 71.004 1.00 56.79  ? 365 ARG B N   1 
ATOM   5575 C CA  . ARG B 1 339 ? -0.109  -26.811 71.304 1.00 59.51  ? 365 ARG B CA  1 
ATOM   5576 C C   . ARG B 1 339 ? -0.413  -26.632 72.791 1.00 62.31  ? 365 ARG B C   1 
ATOM   5577 O O   . ARG B 1 339 ? -1.594  -26.620 73.166 1.00 59.49  ? 365 ARG B O   1 
ATOM   5578 C CB  . ARG B 1 339 ? -0.586  -28.174 70.785 1.00 58.59  ? 365 ARG B CB  1 
ATOM   5579 C CG  . ARG B 1 339 ? -1.803  -28.022 69.851 1.00 61.09  ? 365 ARG B CG  1 
ATOM   5580 C CD  . ARG B 1 339 ? -2.474  -29.344 69.426 1.00 57.92  ? 365 ARG B CD  1 
ATOM   5581 N NE  . ARG B 1 339 ? -3.689  -29.076 68.632 1.00 61.49  ? 365 ARG B NE  1 
ATOM   5582 C CZ  . ARG B 1 339 ? -4.907  -28.975 69.157 1.00 60.65  ? 365 ARG B CZ  1 
ATOM   5583 N NH1 . ARG B 1 339 ? -5.074  -29.130 70.463 1.00 61.18  ? 365 ARG B NH1 1 
ATOM   5584 N NH2 . ARG B 1 339 ? -5.959  -28.717 68.393 1.00 63.92  ? 365 ARG B NH2 1 
ATOM   5585 N N   . GLU B 1 340 ? 0.608   -26.412 73.631 1.00 63.61  ? 366 GLU B N   1 
ATOM   5586 C CA  . GLU B 1 340 ? 0.408   -26.099 75.038 1.00 60.39  ? 366 GLU B CA  1 
ATOM   5587 C C   . GLU B 1 340 ? 0.555   -24.620 75.329 1.00 60.74  ? 366 GLU B C   1 
ATOM   5588 O O   . GLU B 1 340 ? 0.481   -24.229 76.490 1.00 66.69  ? 366 GLU B O   1 
ATOM   5589 C CB  . GLU B 1 340 ? 1.417   -26.853 75.914 1.00 61.37  ? 366 GLU B CB  1 
ATOM   5590 C CG  . GLU B 1 340 ? 1.541   -28.341 75.629 1.00 65.38  ? 366 GLU B CG  1 
ATOM   5591 C CD  . GLU B 1 340 ? 2.851   -28.956 76.138 1.00 66.21  ? 366 GLU B CD  1 
ATOM   5592 O OE1 . GLU B 1 340 ? 3.727   -28.220 76.664 1.00 63.00  ? 366 GLU B OE1 1 
ATOM   5593 O OE2 . GLU B 1 340 ? 2.981   -30.198 76.037 1.00 61.43  ? 366 GLU B OE2 1 
ATOM   5594 N N   . THR B 1 341 ? 0.718   -23.778 74.320 1.00 62.14  ? 367 THR B N   1 
ATOM   5595 C CA  . THR B 1 341 ? 0.897   -22.349 74.556 1.00 58.07  ? 367 THR B CA  1 
ATOM   5596 C C   . THR B 1 341 ? -0.373  -21.588 74.198 1.00 62.15  ? 367 THR B C   1 
ATOM   5597 O O   . THR B 1 341 ? -1.348  -22.153 73.697 1.00 63.50  ? 367 THR B O   1 
ATOM   5598 C CB  . THR B 1 341 ? 2.090   -21.804 73.762 1.00 61.28  ? 367 THR B CB  1 
ATOM   5599 O OG1 . THR B 1 341 ? 1.823   -21.886 72.351 1.00 61.51  ? 367 THR B OG1 1 
ATOM   5600 C CG2 . THR B 1 341 ? 3.326   -22.617 74.082 1.00 58.56  ? 367 THR B CG2 1 
ATOM   5601 N N   . ALA B 1 342 ? -0.366  -20.295 74.507 1.00 61.55  ? 368 ALA B N   1 
ATOM   5602 C CA  . ALA B 1 342 ? -1.525  -19.449 74.259 1.00 66.25  ? 368 ALA B CA  1 
ATOM   5603 C C   . ALA B 1 342 ? -1.669  -19.162 72.762 1.00 66.76  ? 368 ALA B C   1 
ATOM   5604 O O   . ALA B 1 342 ? -0.715  -18.729 72.102 1.00 63.84  ? 368 ALA B O   1 
ATOM   5605 C CB  . ALA B 1 342 ? -1.395  -18.150 75.056 1.00 65.83  ? 368 ALA B CB  1 
ATOM   5606 N N   . ALA B 1 343 ? -2.845  -19.458 72.212 1.00 62.32  ? 369 ALA B N   1 
ATOM   5607 C CA  . ALA B 1 343 ? -3.084  -19.200 70.800 1.00 68.25  ? 369 ALA B CA  1 
ATOM   5608 C C   . ALA B 1 343 ? -3.311  -17.711 70.557 1.00 70.42  ? 369 ALA B C   1 
ATOM   5609 O O   . ALA B 1 343 ? -3.679  -16.971 71.472 1.00 66.33  ? 369 ALA B O   1 
ATOM   5610 C CB  . ALA B 1 343 ? -4.271  -20.017 70.291 1.00 58.92  ? 369 ALA B CB  1 
ATOM   5611 N N   . PRO B 1 344 ? -3.101  -17.248 69.321 1.00 65.99  ? 370 PRO B N   1 
ATOM   5612 C CA  . PRO B 1 344 ? -3.325  -15.818 69.033 1.00 67.33  ? 370 PRO B CA  1 
ATOM   5613 C C   . PRO B 1 344 ? -4.757  -15.363 69.240 1.00 66.76  ? 370 PRO B C   1 
ATOM   5614 O O   . PRO B 1 344 ? -4.986  -14.291 69.811 1.00 66.86  ? 370 PRO B O   1 
ATOM   5615 C CB  . PRO B 1 344 ? -2.903  -15.690 67.562 1.00 67.70  ? 370 PRO B CB  1 
ATOM   5616 C CG  . PRO B 1 344 ? -1.917  -16.788 67.362 1.00 68.68  ? 370 PRO B CG  1 
ATOM   5617 C CD  . PRO B 1 344 ? -2.366  -17.926 68.244 1.00 63.34  ? 370 PRO B CD  1 
ATOM   5618 N N   . VAL B 1 345 ? -5.731  -16.139 68.783 1.00 72.48  ? 371 VAL B N   1 
ATOM   5619 C CA  . VAL B 1 345 ? -7.143  -15.782 68.883 1.00 66.98  ? 371 VAL B CA  1 
ATOM   5620 C C   . VAL B 1 345 ? -7.864  -16.903 69.618 1.00 69.88  ? 371 VAL B C   1 
ATOM   5621 O O   . VAL B 1 345 ? -7.986  -18.019 69.097 1.00 75.17  ? 371 VAL B O   1 
ATOM   5622 C CB  . VAL B 1 345 ? -7.772  -15.554 67.501 1.00 70.02  ? 371 VAL B CB  1 
ATOM   5623 C CG1 . VAL B 1 345 ? -9.222  -15.089 67.649 1.00 74.04  ? 371 VAL B CG1 1 
ATOM   5624 C CG2 . VAL B 1 345 ? -6.947  -14.589 66.675 1.00 66.70  ? 371 VAL B CG2 1 
ATOM   5625 N N   . VAL B 1 346 ? -8.353  -16.620 70.814 1.00 70.86  ? 372 VAL B N   1 
ATOM   5626 C CA  . VAL B 1 346 ? -9.211  -17.547 71.546 1.00 73.09  ? 372 VAL B CA  1 
ATOM   5627 C C   . VAL B 1 346 ? -10.664 -17.125 71.357 1.00 75.39  ? 372 VAL B C   1 
ATOM   5628 O O   . VAL B 1 346 ? -11.013 -15.988 71.708 1.00 78.97  ? 372 VAL B O   1 
ATOM   5629 C CB  . VAL B 1 346 ? -8.848  -17.593 73.029 1.00 69.80  ? 372 VAL B CB  1 
ATOM   5630 C CG1 . VAL B 1 346 ? -9.805  -18.542 73.759 1.00 65.47  ? 372 VAL B CG1 1 
ATOM   5631 C CG2 . VAL B 1 346 ? -7.411  -18.030 73.162 1.00 71.38  ? 372 VAL B CG2 1 
ATOM   5632 N N   . PRO B 1 347 ? -11.539 -17.999 70.874 1.00 72.50  ? 373 PRO B N   1 
ATOM   5633 C CA  . PRO B 1 347 ? -12.929 -17.579 70.631 1.00 79.76  ? 373 PRO B CA  1 
ATOM   5634 C C   . PRO B 1 347 ? -13.701 -17.336 71.927 1.00 75.80  ? 373 PRO B C   1 
ATOM   5635 O O   . PRO B 1 347 ? -13.583 -18.080 72.902 1.00 76.77  ? 373 PRO B O   1 
ATOM   5636 C CB  . PRO B 1 347 ? -13.522 -18.748 69.835 1.00 77.87  ? 373 PRO B CB  1 
ATOM   5637 C CG  . PRO B 1 347 ? -12.671 -19.935 70.212 1.00 77.12  ? 373 PRO B CG  1 
ATOM   5638 C CD  . PRO B 1 347 ? -11.291 -19.404 70.511 1.00 70.44  ? 373 PRO B CD  1 
ATOM   5639 N N   . GLU B 1 348 ? -14.478 -16.259 71.928 1.00 77.67  ? 374 GLU B N   1 
ATOM   5640 C CA  . GLU B 1 348 ? -15.424 -15.957 72.996 1.00 82.11  ? 374 GLU B CA  1 
ATOM   5641 C C   . GLU B 1 348 ? -16.778 -16.537 72.608 1.00 75.47  ? 374 GLU B C   1 
ATOM   5642 O O   . GLU B 1 348 ? -17.355 -16.137 71.591 1.00 78.29  ? 374 GLU B O   1 
ATOM   5643 C CB  . GLU B 1 348 ? -15.525 -14.446 73.225 1.00 84.09  ? 374 GLU B CB  1 
ATOM   5644 N N   . LEU B 1 349 ? -17.272 -17.490 73.399 1.00 69.91  ? 375 LEU B N   1 
ATOM   5645 C CA  . LEU B 1 349 ? -18.454 -18.262 73.047 1.00 74.66  ? 375 LEU B CA  1 
ATOM   5646 C C   . LEU B 1 349 ? -19.550 -18.067 74.088 1.00 73.46  ? 375 LEU B C   1 
ATOM   5647 O O   . LEU B 1 349 ? -19.284 -18.123 75.291 1.00 69.14  ? 375 LEU B O   1 
ATOM   5648 C CB  . LEU B 1 349 ? -18.098 -19.748 72.880 1.00 71.40  ? 375 LEU B CB  1 
ATOM   5649 C CG  . LEU B 1 349 ? -17.020 -19.947 71.802 1.00 73.62  ? 375 LEU B CG  1 
ATOM   5650 C CD1 . LEU B 1 349 ? -16.178 -21.177 72.059 1.00 70.13  ? 375 LEU B CD1 1 
ATOM   5651 C CD2 . LEU B 1 349 ? -17.639 -19.969 70.412 1.00 70.79  ? 375 LEU B CD2 1 
ATOM   5652 N N   . SER B 1 350 ? -20.776 -17.824 73.617 1.00 72.37  ? 376 SER B N   1 
ATOM   5653 C CA  . SER B 1 350 ? -21.898 -17.527 74.495 1.00 76.83  ? 376 SER B CA  1 
ATOM   5654 C C   . SER B 1 350 ? -22.712 -18.753 74.915 1.00 79.42  ? 376 SER B C   1 
ATOM   5655 O O   . SER B 1 350 ? -23.489 -18.655 75.875 1.00 80.07  ? 376 SER B O   1 
ATOM   5656 C CB  . SER B 1 350 ? -22.819 -16.517 73.808 1.00 73.98  ? 376 SER B CB  1 
ATOM   5657 O OG  . SER B 1 350 ? -23.309 -17.041 72.590 1.00 75.59  ? 376 SER B OG  1 
ATOM   5658 N N   . SER B 1 351 ? -22.576 -19.888 74.225 1.00 74.74  ? 377 SER B N   1 
ATOM   5659 C CA  . SER B 1 351 ? -23.369 -21.085 74.499 1.00 75.14  ? 377 SER B CA  1 
ATOM   5660 C C   . SER B 1 351 ? -22.683 -22.265 73.821 1.00 75.43  ? 377 SER B C   1 
ATOM   5661 O O   . SER B 1 351 ? -21.799 -22.091 72.979 1.00 73.01  ? 377 SER B O   1 
ATOM   5662 C CB  . SER B 1 351 ? -24.840 -20.946 74.060 1.00 74.59  ? 377 SER B CB  1 
ATOM   5663 O OG  . SER B 1 351 ? -25.037 -20.947 72.653 1.00 69.20  ? 377 SER B OG  1 
ATOM   5664 N N   . ASP B 1 352 ? -23.113 -23.476 74.181 1.00 70.69  ? 378 ASP B N   1 
ATOM   5665 C CA  . ASP B 1 352 ? -22.554 -24.651 73.526 1.00 71.71  ? 378 ASP B CA  1 
ATOM   5666 C C   . ASP B 1 352 ? -22.971 -24.774 72.061 1.00 72.66  ? 378 ASP B C   1 
ATOM   5667 O O   . ASP B 1 352 ? -22.490 -25.677 71.371 1.00 70.95  ? 378 ASP B O   1 
ATOM   5668 C CB  . ASP B 1 352 ? -22.941 -25.921 74.307 1.00 74.00  ? 378 ASP B CB  1 
ATOM   5669 C CG  . ASP B 1 352 ? -24.455 -26.194 74.324 1.00 74.98  ? 378 ASP B CG  1 
ATOM   5670 O OD1 . ASP B 1 352 ? -25.244 -25.446 73.696 1.00 73.80  ? 378 ASP B OD1 1 
ATOM   5671 O OD2 . ASP B 1 352 ? -24.868 -27.184 74.976 1.00 73.22  ? 378 ASP B OD2 1 
ATOM   5672 N N   . ILE B 1 353 ? -23.815 -23.870 71.564 1.00 72.18  ? 379 ILE B N   1 
ATOM   5673 C CA  . ILE B 1 353 ? -24.221 -23.836 70.171 1.00 68.59  ? 379 ILE B CA  1 
ATOM   5674 C C   . ILE B 1 353 ? -23.891 -22.503 69.502 1.00 70.17  ? 379 ILE B C   1 
ATOM   5675 O O   . ILE B 1 353 ? -24.403 -22.215 68.420 1.00 69.67  ? 379 ILE B O   1 
ATOM   5676 C CB  . ILE B 1 353 ? -25.719 -24.164 70.029 1.00 71.00  ? 379 ILE B CB  1 
ATOM   5677 C CG1 . ILE B 1 353 ? -26.558 -23.233 70.908 1.00 70.49  ? 379 ILE B CG1 1 
ATOM   5678 C CG2 . ILE B 1 353 ? -25.971 -25.603 70.411 1.00 68.25  ? 379 ILE B CG2 1 
ATOM   5679 C CD1 . ILE B 1 353 ? -28.038 -23.287 70.605 1.00 66.73  ? 379 ILE B CD1 1 
ATOM   5680 N N   . ASP B 1 354 ? -23.043 -21.686 70.118 1.00 65.87  ? 380 ASP B N   1 
ATOM   5681 C CA  . ASP B 1 354 ? -22.539 -20.484 69.463 1.00 67.33  ? 380 ASP B CA  1 
ATOM   5682 C C   . ASP B 1 354 ? -21.815 -20.864 68.174 1.00 69.04  ? 380 ASP B C   1 
ATOM   5683 O O   . ASP B 1 354 ? -20.802 -21.560 68.204 1.00 63.04  ? 380 ASP B O   1 
ATOM   5684 C CB  . ASP B 1 354 ? -21.603 -19.738 70.426 1.00 67.58  ? 380 ASP B CB  1 
ATOM   5685 C CG  . ASP B 1 354 ? -21.063 -18.416 69.862 1.00 73.55  ? 380 ASP B CG  1 
ATOM   5686 O OD1 . ASP B 1 354 ? -20.846 -18.288 68.638 1.00 72.91  ? 380 ASP B OD1 1 
ATOM   5687 O OD2 . ASP B 1 354 ? -20.831 -17.493 70.674 1.00 79.53  ? 380 ASP B OD2 1 
ATOM   5688 N N   . SER B 1 355 ? -22.314 -20.383 67.041 1.00 71.22  ? 381 SER B N   1 
ATOM   5689 C CA  . SER B 1 355 ? -21.690 -20.634 65.746 1.00 73.60  ? 381 SER B CA  1 
ATOM   5690 C C   . SER B 1 355 ? -21.282 -19.330 65.072 1.00 72.93  ? 381 SER B C   1 
ATOM   5691 O O   . SER B 1 355 ? -21.160 -19.258 63.844 1.00 74.50  ? 381 SER B O   1 
ATOM   5692 C CB  . SER B 1 355 ? -22.625 -21.443 64.853 1.00 70.91  ? 381 SER B CB  1 
ATOM   5693 O OG  . SER B 1 355 ? -23.930 -20.911 64.925 1.00 74.31  ? 381 SER B OG  1 
ATOM   5694 N N   . SER B 1 356 ? -21.048 -18.298 65.881 1.00 73.22  ? 382 SER B N   1 
ATOM   5695 C CA  . SER B 1 356 ? -20.789 -16.963 65.356 1.00 73.32  ? 382 SER B CA  1 
ATOM   5696 C C   . SER B 1 356 ? -19.541 -16.906 64.486 1.00 76.30  ? 382 SER B C   1 
ATOM   5697 O O   . SER B 1 356 ? -19.403 -15.969 63.693 1.00 77.37  ? 382 SER B O   1 
ATOM   5698 C CB  . SER B 1 356 ? -20.658 -15.968 66.513 1.00 75.04  ? 382 SER B CB  1 
ATOM   5699 O OG  . SER B 1 356 ? -19.769 -16.448 67.519 1.00 74.82  ? 382 SER B OG  1 
ATOM   5700 N N   . ASN B 1 357 ? -18.632 -17.876 64.600 1.00 73.47  ? 383 ASN B N   1 
ATOM   5701 C CA  . ASN B 1 357 ? -17.460 -17.905 63.733 1.00 69.45  ? 383 ASN B CA  1 
ATOM   5702 C C   . ASN B 1 357 ? -17.703 -18.664 62.438 1.00 69.81  ? 383 ASN B C   1 
ATOM   5703 O O   . ASN B 1 357 ? -16.740 -19.001 61.743 1.00 72.38  ? 383 ASN B O   1 
ATOM   5704 C CB  . ASN B 1 357 ? -16.270 -18.498 64.476 1.00 66.48  ? 383 ASN B CB  1 
ATOM   5705 C CG  . ASN B 1 357 ? -15.848 -17.638 65.661 1.00 73.06  ? 383 ASN B CG  1 
ATOM   5706 O OD1 . ASN B 1 357 ? -15.614 -16.437 65.514 1.00 75.53  ? 383 ASN B OD1 1 
ATOM   5707 N ND2 . ASN B 1 357 ? -15.760 -18.245 66.843 1.00 73.76  ? 383 ASN B ND2 1 
ATOM   5708 N N   . PHE B 1 358 ? -18.964 -18.947 62.105 1.00 69.30  ? 384 PHE B N   1 
ATOM   5709 C CA  . PHE B 1 358 ? -19.344 -19.612 60.861 1.00 72.94  ? 384 PHE B CA  1 
ATOM   5710 C C   . PHE B 1 358 ? -20.423 -18.788 60.176 1.00 76.94  ? 384 PHE B C   1 
ATOM   5711 O O   . PHE B 1 358 ? -21.432 -18.442 60.802 1.00 75.42  ? 384 PHE B O   1 
ATOM   5712 C CB  . PHE B 1 358 ? -19.865 -21.037 61.120 1.00 72.61  ? 384 PHE B CB  1 
ATOM   5713 C CG  . PHE B 1 358 ? -18.831 -21.965 61.698 1.00 72.37  ? 384 PHE B CG  1 
ATOM   5714 C CD1 . PHE B 1 358 ? -17.923 -22.607 60.872 1.00 62.24  ? 384 PHE B CD1 1 
ATOM   5715 C CD2 . PHE B 1 358 ? -18.748 -22.166 63.069 1.00 65.96  ? 384 PHE B CD2 1 
ATOM   5716 C CE1 . PHE B 1 358 ? -16.968 -23.439 61.389 1.00 63.20  ? 384 PHE B CE1 1 
ATOM   5717 C CE2 . PHE B 1 358 ? -17.785 -23.013 63.597 1.00 66.44  ? 384 PHE B CE2 1 
ATOM   5718 C CZ  . PHE B 1 358 ? -16.899 -23.657 62.756 1.00 64.17  ? 384 PHE B CZ  1 
ATOM   5719 N N   . ASP B 1 359 ? -20.219 -18.481 58.896 1.00 77.71  ? 385 ASP B N   1 
ATOM   5720 C CA  . ASP B 1 359 ? -21.225 -17.752 58.135 1.00 85.65  ? 385 ASP B CA  1 
ATOM   5721 C C   . ASP B 1 359 ? -22.477 -18.594 57.907 1.00 87.41  ? 385 ASP B C   1 
ATOM   5722 O O   . ASP B 1 359 ? -22.439 -19.828 57.905 1.00 89.55  ? 385 ASP B O   1 
ATOM   5723 C CB  . ASP B 1 359 ? -20.652 -17.300 56.798 1.00 85.72  ? 385 ASP B CB  1 
ATOM   5724 C CG  . ASP B 1 359 ? -19.407 -16.452 56.968 1.00 90.81  ? 385 ASP B CG  1 
ATOM   5725 O OD1 . ASP B 1 359 ? -19.399 -15.585 57.872 1.00 89.76  ? 385 ASP B OD1 1 
ATOM   5726 O OD2 . ASP B 1 359 ? -18.432 -16.665 56.216 1.00 90.59  ? 385 ASP B OD2 1 
ATOM   5727 N N   . ASP B 1 360 ? -23.602 -17.908 57.734 1.00 89.02  ? 386 ASP B N   1 
ATOM   5728 C CA  . ASP B 1 360 ? -24.833 -18.573 57.338 1.00 91.88  ? 386 ASP B CA  1 
ATOM   5729 C C   . ASP B 1 360 ? -24.693 -19.103 55.916 1.00 92.77  ? 386 ASP B C   1 
ATOM   5730 O O   . ASP B 1 360 ? -23.881 -18.618 55.121 1.00 94.04  ? 386 ASP B O   1 
ATOM   5731 C CB  . ASP B 1 360 ? -26.003 -17.612 57.456 1.00 96.40  ? 386 ASP B CB  1 
ATOM   5732 C CG  . ASP B 1 360 ? -25.897 -16.754 58.690 1.00 101.43 ? 386 ASP B CG  1 
ATOM   5733 O OD1 . ASP B 1 360 ? -25.808 -17.324 59.798 1.00 102.22 ? 386 ASP B OD1 1 
ATOM   5734 O OD2 . ASP B 1 360 ? -25.862 -15.513 58.552 1.00 109.94 ? 386 ASP B OD2 1 
ATOM   5735 N N   . ILE B 1 361 ? -25.501 -20.106 55.589 1.00 91.57  ? 387 ILE B N   1 
ATOM   5736 C CA  . ILE B 1 361 ? -25.443 -20.732 54.277 1.00 90.35  ? 387 ILE B CA  1 
ATOM   5737 C C   . ILE B 1 361 ? -26.847 -20.875 53.711 1.00 95.72  ? 387 ILE B C   1 
ATOM   5738 O O   . ILE B 1 361 ? -27.799 -21.166 54.446 1.00 88.67  ? 387 ILE B O   1 
ATOM   5739 C CB  . ILE B 1 361 ? -24.708 -22.087 54.364 1.00 84.84  ? 387 ILE B CB  1 
ATOM   5740 C CG1 . ILE B 1 361 ? -23.229 -21.818 54.684 1.00 83.08  ? 387 ILE B CG1 1 
ATOM   5741 C CG2 . ILE B 1 361 ? -24.867 -22.890 53.085 1.00 80.12  ? 387 ILE B CG2 1 
ATOM   5742 C CD1 . ILE B 1 361 ? -22.445 -23.010 55.059 1.00 72.38  ? 387 ILE B CD1 1 
ATOM   5743 N N   . GLU B 1 362 ? -26.967 -20.619 52.403 1.00 97.07  ? 388 GLU B N   1 
ATOM   5744 C CA  . GLU B 1 362 ? -28.242 -20.537 51.690 1.00 98.55  ? 388 GLU B CA  1 
ATOM   5745 C C   . GLU B 1 362 ? -28.699 -21.903 51.185 1.00 98.61  ? 388 GLU B C   1 
ATOM   5746 O O   . GLU B 1 362 ? -29.100 -22.765 51.968 1.00 100.52 ? 388 GLU B O   1 
ATOM   5747 C CB  . GLU B 1 362 ? -28.130 -19.563 50.512 1.00 96.10  ? 388 GLU B CB  1 
ATOM   5748 N N   . GLU B 1 369 ? -33.209 -34.698 45.314 1.00 109.22 ? 395 GLU B N   1 
ATOM   5749 C CA  . GLU B 1 369 ? -33.465 -35.628 44.218 1.00 105.52 ? 395 GLU B CA  1 
ATOM   5750 C C   . GLU B 1 369 ? -33.637 -37.041 44.770 1.00 107.14 ? 395 GLU B C   1 
ATOM   5751 O O   . GLU B 1 369 ? -33.242 -37.309 45.902 1.00 107.06 ? 395 GLU B O   1 
ATOM   5752 C CB  . GLU B 1 369 ? -32.333 -35.576 43.194 1.00 98.81  ? 395 GLU B CB  1 
ATOM   5753 N N   . THR B 1 370 ? -34.238 -37.939 43.982 1.00 110.18 ? 396 THR B N   1 
ATOM   5754 C CA  . THR B 1 370 ? -34.594 -39.276 44.449 1.00 109.62 ? 396 THR B CA  1 
ATOM   5755 C C   . THR B 1 370 ? -34.115 -40.335 43.458 1.00 107.04 ? 396 THR B C   1 
ATOM   5756 O O   . THR B 1 370 ? -33.930 -40.073 42.264 1.00 107.13 ? 396 THR B O   1 
ATOM   5757 C CB  . THR B 1 370 ? -36.123 -39.400 44.667 1.00 112.39 ? 396 THR B CB  1 
ATOM   5758 O OG1 . THR B 1 370 ? -36.476 -40.761 44.958 1.00 109.31 ? 396 THR B OG1 1 
ATOM   5759 C CG2 . THR B 1 370 ? -36.900 -38.910 43.430 1.00 109.95 ? 396 THR B CG2 1 
ATOM   5760 N N   . PHE B 1 371 ? -33.921 -41.548 43.973 1.00 106.85 ? 397 PHE B N   1 
ATOM   5761 C CA  . PHE B 1 371 ? -33.392 -42.636 43.164 1.00 105.64 ? 397 PHE B CA  1 
ATOM   5762 C C   . PHE B 1 371 ? -34.423 -43.159 42.167 1.00 104.39 ? 397 PHE B C   1 
ATOM   5763 O O   . PHE B 1 371 ? -35.621 -43.202 42.462 1.00 103.75 ? 397 PHE B O   1 
ATOM   5764 C CB  . PHE B 1 371 ? -32.931 -43.782 44.051 1.00 104.29 ? 397 PHE B CB  1 
ATOM   5765 C CG  . PHE B 1 371 ? -31.485 -43.703 44.411 1.00 102.37 ? 397 PHE B CG  1 
ATOM   5766 C CD1 . PHE B 1 371 ? -30.513 -43.723 43.420 1.00 95.94  ? 397 PHE B CD1 1 
ATOM   5767 C CD2 . PHE B 1 371 ? -31.096 -43.574 45.736 1.00 100.54 ? 397 PHE B CD2 1 
ATOM   5768 C CE1 . PHE B 1 371 ? -29.168 -43.641 43.741 1.00 91.10  ? 397 PHE B CE1 1 
ATOM   5769 C CE2 . PHE B 1 371 ? -29.755 -43.489 46.077 1.00 94.05  ? 397 PHE B CE2 1 
ATOM   5770 C CZ  . PHE B 1 371 ? -28.786 -43.520 45.071 1.00 91.78  ? 397 PHE B CZ  1 
ATOM   5771 N N   . PRO B 1 372 ? -33.978 -43.596 40.988 1.00 102.01 ? 398 PRO B N   1 
ATOM   5772 C CA  . PRO B 1 372 ? -34.895 -44.299 40.078 1.00 101.81 ? 398 PRO B CA  1 
ATOM   5773 C C   . PRO B 1 372 ? -35.102 -45.744 40.528 1.00 100.74 ? 398 PRO B C   1 
ATOM   5774 O O   . PRO B 1 372 ? -34.137 -46.491 40.716 1.00 102.40 ? 398 PRO B O   1 
ATOM   5775 C CB  . PRO B 1 372 ? -34.180 -44.223 38.721 1.00 98.11  ? 398 PRO B CB  1 
ATOM   5776 C CG  . PRO B 1 372 ? -32.718 -44.102 39.065 1.00 99.27  ? 398 PRO B CG  1 
ATOM   5777 C CD  . PRO B 1 372 ? -32.633 -43.403 40.407 1.00 102.25 ? 398 PRO B CD  1 
ATOM   5778 N N   . ILE B 1 373 ? -36.367 -46.132 40.705 1.00 95.74  ? 399 ILE B N   1 
ATOM   5779 C CA  . ILE B 1 373 ? -36.756 -47.521 40.956 1.00 92.28  ? 399 ILE B CA  1 
ATOM   5780 C C   . ILE B 1 373 ? -36.168 -48.396 39.856 1.00 93.93  ? 399 ILE B C   1 
ATOM   5781 O O   . ILE B 1 373 ? -36.437 -48.160 38.671 1.00 96.70  ? 399 ILE B O   1 
ATOM   5782 C CB  . ILE B 1 373 ? -38.282 -47.686 41.024 1.00 91.17  ? 399 ILE B CB  1 
ATOM   5783 C CG1 . ILE B 1 373 ? -38.858 -46.906 42.210 1.00 88.14  ? 399 ILE B CG1 1 
ATOM   5784 C CG2 . ILE B 1 373 ? -38.652 -49.165 41.092 1.00 86.86  ? 399 ILE B CG2 1 
ATOM   5785 C CD1 . ILE B 1 373 ? -38.983 -47.719 43.486 1.00 94.77  ? 399 ILE B CD1 1 
ATOM   5786 N N   . PRO B 1 374 ? -35.373 -49.409 40.184 1.00 95.06  ? 400 PRO B N   1 
ATOM   5787 C CA  . PRO B 1 374 ? -34.640 -50.132 39.145 1.00 95.28  ? 400 PRO B CA  1 
ATOM   5788 C C   . PRO B 1 374 ? -35.451 -51.243 38.501 1.00 91.12  ? 400 PRO B C   1 
ATOM   5789 O O   . PRO B 1 374 ? -36.360 -51.829 39.092 1.00 86.47  ? 400 PRO B O   1 
ATOM   5790 C CB  . PRO B 1 374 ? -33.453 -50.713 39.921 1.00 92.79  ? 400 PRO B CB  1 
ATOM   5791 C CG  . PRO B 1 374 ? -34.028 -50.987 41.270 1.00 92.34  ? 400 PRO B CG  1 
ATOM   5792 C CD  . PRO B 1 374 ? -35.088 -49.938 41.529 1.00 91.81  ? 400 PRO B CD  1 
ATOM   5793 N N   . LYS B 1 375 ? -35.078 -51.540 37.259 1.00 92.42  ? 401 LYS B N   1 
ATOM   5794 C CA  . LYS B 1 375 ? -35.667 -52.645 36.517 1.00 94.49  ? 401 LYS B CA  1 
ATOM   5795 C C   . LYS B 1 375 ? -34.794 -53.891 36.553 1.00 93.19  ? 401 LYS B C   1 
ATOM   5796 O O   . LYS B 1 375 ? -35.318 -55.009 36.463 1.00 90.18  ? 401 LYS B O   1 
ATOM   5797 C CB  . LYS B 1 375 ? -35.921 -52.228 35.062 1.00 94.49  ? 401 LYS B CB  1 
ATOM   5798 N N   . ALA B 1 376 ? -33.479 -53.706 36.693 1.00 94.39  ? 402 ALA B N   1 
ATOM   5799 C CA  . ALA B 1 376 ? -32.487 -54.740 36.968 1.00 88.91  ? 402 ALA B CA  1 
ATOM   5800 C C   . ALA B 1 376 ? -31.743 -54.385 38.258 1.00 87.81  ? 402 ALA B C   1 
ATOM   5801 O O   . ALA B 1 376 ? -32.003 -53.354 38.888 1.00 88.37  ? 402 ALA B O   1 
ATOM   5802 C CB  . ALA B 1 376 ? -31.518 -54.895 35.795 1.00 87.89  ? 402 ALA B CB  1 
ATOM   5803 N N   . PHE B 1 377 ? -30.816 -55.251 38.660 1.00 86.57  ? 403 PHE B N   1 
ATOM   5804 C CA  . PHE B 1 377 ? -29.974 -54.960 39.814 1.00 86.07  ? 403 PHE B CA  1 
ATOM   5805 C C   . PHE B 1 377 ? -28.994 -53.842 39.481 1.00 83.04  ? 403 PHE B C   1 
ATOM   5806 O O   . PHE B 1 377 ? -28.164 -53.980 38.579 1.00 85.69  ? 403 PHE B O   1 
ATOM   5807 C CB  . PHE B 1 377 ? -29.227 -56.211 40.255 1.00 84.17  ? 403 PHE B CB  1 
ATOM   5808 C CG  . PHE B 1 377 ? -28.368 -56.017 41.480 1.00 84.10  ? 403 PHE B CG  1 
ATOM   5809 C CD1 . PHE B 1 377 ? -28.936 -55.994 42.747 1.00 84.07  ? 403 PHE B CD1 1 
ATOM   5810 C CD2 . PHE B 1 377 ? -26.988 -55.882 41.364 1.00 81.61  ? 403 PHE B CD2 1 
ATOM   5811 C CE1 . PHE B 1 377 ? -28.147 -55.828 43.869 1.00 82.04  ? 403 PHE B CE1 1 
ATOM   5812 C CE2 . PHE B 1 377 ? -26.195 -55.714 42.476 1.00 78.08  ? 403 PHE B CE2 1 
ATOM   5813 C CZ  . PHE B 1 377 ? -26.766 -55.689 43.728 1.00 81.79  ? 403 PHE B CZ  1 
ATOM   5814 N N   . VAL B 1 378 ? -29.095 -52.735 40.211 1.00 84.46  ? 404 VAL B N   1 
ATOM   5815 C CA  . VAL B 1 378 ? -28.220 -51.576 40.043 1.00 85.27  ? 404 VAL B CA  1 
ATOM   5816 C C   . VAL B 1 378 ? -27.100 -51.545 41.083 1.00 85.56  ? 404 VAL B C   1 
ATOM   5817 O O   . VAL B 1 378 ? -25.953 -51.257 40.741 1.00 84.59  ? 404 VAL B O   1 
ATOM   5818 C CB  . VAL B 1 378 ? -29.057 -50.275 40.070 1.00 84.51  ? 404 VAL B CB  1 
ATOM   5819 C CG1 . VAL B 1 378 ? -30.020 -50.246 38.893 1.00 88.78  ? 404 VAL B CG1 1 
ATOM   5820 C CG2 . VAL B 1 378 ? -29.850 -50.147 41.364 1.00 85.79  ? 404 VAL B CG2 1 
ATOM   5821 N N   . GLY B 1 379 ? -27.406 -51.836 42.349 1.00 83.00  ? 405 GLY B N   1 
ATOM   5822 C CA  . GLY B 1 379 ? -26.391 -51.869 43.390 1.00 82.87  ? 405 GLY B CA  1 
ATOM   5823 C C   . GLY B 1 379 ? -25.994 -50.507 43.924 1.00 82.33  ? 405 GLY B C   1 
ATOM   5824 O O   . GLY B 1 379 ? -24.800 -50.252 44.150 1.00 76.48  ? 405 GLY B O   1 
ATOM   5825 N N   . ASN B 1 380 ? -26.968 -49.615 44.132 1.00 83.34  ? 406 ASN B N   1 
ATOM   5826 C CA  . ASN B 1 380 ? -26.646 -48.252 44.548 1.00 83.34  ? 406 ASN B CA  1 
ATOM   5827 C C   . ASN B 1 380 ? -26.106 -48.197 45.972 1.00 81.89  ? 406 ASN B C   1 
ATOM   5828 O O   . ASN B 1 380 ? -25.313 -47.305 46.295 1.00 77.69  ? 406 ASN B O   1 
ATOM   5829 C CB  . ASN B 1 380 ? -27.879 -47.351 44.424 1.00 84.22  ? 406 ASN B CB  1 
ATOM   5830 C CG  . ASN B 1 380 ? -28.196 -46.973 42.980 1.00 85.07  ? 406 ASN B CG  1 
ATOM   5831 O OD1 . ASN B 1 380 ? -27.300 -46.869 42.135 1.00 83.27  ? 406 ASN B OD1 1 
ATOM   5832 N ND2 . ASN B 1 380 ? -29.479 -46.749 42.701 1.00 81.55  ? 406 ASN B ND2 1 
ATOM   5833 N N   . GLN B 1 381 ? -26.481 -49.151 46.821 1.00 80.55  ? 407 GLN B N   1 
ATOM   5834 C CA  . GLN B 1 381 ? -25.995 -49.176 48.191 1.00 76.23  ? 407 GLN B CA  1 
ATOM   5835 C C   . GLN B 1 381 ? -24.672 -49.906 48.320 1.00 78.41  ? 407 GLN B C   1 
ATOM   5836 O O   . GLN B 1 381 ? -24.044 -49.839 49.385 1.00 78.72  ? 407 GLN B O   1 
ATOM   5837 C CB  . GLN B 1 381 ? -27.024 -49.817 49.103 1.00 77.35  ? 407 GLN B CB  1 
ATOM   5838 C CG  . GLN B 1 381 ? -28.387 -49.143 48.989 1.00 82.50  ? 407 GLN B CG  1 
ATOM   5839 C CD  . GLN B 1 381 ? -28.454 -47.789 49.701 1.00 79.19  ? 407 GLN B CD  1 
ATOM   5840 O OE1 . GLN B 1 381 ? -27.595 -47.437 50.520 1.00 70.18  ? 407 GLN B OE1 1 
ATOM   5841 N NE2 . GLN B 1 381 ? -29.459 -47.006 49.346 1.00 76.84  ? 407 GLN B NE2 1 
ATOM   5842 N N   . LEU B 1 382 ? -24.228 -50.575 47.253 1.00 75.99  ? 408 LEU B N   1 
ATOM   5843 C CA  . LEU B 1 382 ? -22.991 -51.339 47.327 1.00 74.73  ? 408 LEU B CA  1 
ATOM   5844 C C   . LEU B 1 382 ? -21.785 -50.455 47.620 1.00 78.25  ? 408 LEU B C   1 
ATOM   5845 O O   . LEU B 1 382 ? -20.939 -50.865 48.421 1.00 81.03  ? 408 LEU B O   1 
ATOM   5846 C CB  . LEU B 1 382 ? -22.752 -52.113 46.031 1.00 81.68  ? 408 LEU B CB  1 
ATOM   5847 C CG  . LEU B 1 382 ? -23.415 -53.504 45.995 1.00 80.69  ? 408 LEU B CG  1 
ATOM   5848 C CD1 . LEU B 1 382 ? -23.581 -53.913 44.552 1.00 81.96  ? 408 LEU B CD1 1 
ATOM   5849 C CD2 . LEU B 1 382 ? -22.578 -54.511 46.759 1.00 79.46  ? 408 LEU B CD2 1 
ATOM   5850 N N   . PRO B 1 383 ? -21.650 -49.240 47.084 1.00 79.84  ? 409 PRO B N   1 
ATOM   5851 C CA  . PRO B 1 383 ? -20.453 -48.429 47.403 1.00 76.46  ? 409 PRO B CA  1 
ATOM   5852 C C   . PRO B 1 383 ? -20.364 -47.976 48.876 1.00 79.51  ? 409 PRO B C   1 
ATOM   5853 O O   . PRO B 1 383 ? -19.305 -47.495 49.272 1.00 76.63  ? 409 PRO B O   1 
ATOM   5854 C CB  . PRO B 1 383 ? -20.586 -47.219 46.430 1.00 77.04  ? 409 PRO B CB  1 
ATOM   5855 C CG  . PRO B 1 383 ? -21.439 -47.702 45.316 1.00 81.67  ? 409 PRO B CG  1 
ATOM   5856 C CD  . PRO B 1 383 ? -22.409 -48.671 45.950 1.00 79.86  ? 409 PRO B CD  1 
ATOM   5857 N N   . PHE B 1 384 ? -21.415 -48.102 49.693 1.00 74.56  ? 410 PHE B N   1 
ATOM   5858 C CA  . PHE B 1 384 ? -21.375 -47.572 51.054 1.00 72.37  ? 410 PHE B CA  1 
ATOM   5859 C C   . PHE B 1 384 ? -21.259 -48.654 52.139 1.00 70.11  ? 410 PHE B C   1 
ATOM   5860 O O   . PHE B 1 384 ? -21.309 -48.343 53.342 1.00 71.45  ? 410 PHE B O   1 
ATOM   5861 C CB  . PHE B 1 384 ? -22.572 -46.646 51.212 1.00 71.12  ? 410 PHE B CB  1 
ATOM   5862 C CG  . PHE B 1 384 ? -22.692 -45.715 50.020 1.00 70.71  ? 410 PHE B CG  1 
ATOM   5863 C CD1 . PHE B 1 384 ? -21.738 -44.718 49.808 1.00 68.31  ? 410 PHE B CD1 1 
ATOM   5864 C CD2 . PHE B 1 384 ? -23.656 -45.932 49.033 1.00 74.80  ? 410 PHE B CD2 1 
ATOM   5865 C CE1 . PHE B 1 384 ? -21.783 -43.896 48.666 1.00 74.24  ? 410 PHE B CE1 1 
ATOM   5866 C CE2 . PHE B 1 384 ? -23.702 -45.112 47.891 1.00 75.09  ? 410 PHE B CE2 1 
ATOM   5867 C CZ  . PHE B 1 384 ? -22.765 -44.097 47.717 1.00 72.39  ? 410 PHE B CZ  1 
ATOM   5868 N N   . ILE B 1 385 ? -20.997 -49.894 51.738 1.00 71.70  ? 411 ILE B N   1 
ATOM   5869 C CA  . ILE B 1 385 ? -20.905 -51.020 52.661 1.00 66.81  ? 411 ILE B CA  1 
ATOM   5870 C C   . ILE B 1 385 ? -19.606 -50.921 53.448 1.00 68.96  ? 411 ILE B C   1 
ATOM   5871 O O   . ILE B 1 385 ? -18.520 -50.798 52.868 1.00 65.80  ? 411 ILE B O   1 
ATOM   5872 C CB  . ILE B 1 385 ? -21.017 -52.350 51.891 1.00 69.63  ? 411 ILE B CB  1 
ATOM   5873 C CG1 . ILE B 1 385 ? -22.500 -52.604 51.537 1.00 68.04  ? 411 ILE B CG1 1 
ATOM   5874 C CG2 . ILE B 1 385 ? -20.410 -53.508 52.671 1.00 65.01  ? 411 ILE B CG2 1 
ATOM   5875 C CD1 . ILE B 1 385 ? -22.743 -53.740 50.573 1.00 70.16  ? 411 ILE B CD1 1 
ATOM   5876 N N   . GLY B 1 386 ? -19.722 -50.955 54.784 1.00 71.83  ? 412 GLY B N   1 
ATOM   5877 C CA  . GLY B 1 386 ? -18.596 -50.768 55.681 1.00 69.07  ? 412 GLY B CA  1 
ATOM   5878 C C   . GLY B 1 386 ? -18.422 -49.362 56.228 1.00 67.75  ? 412 GLY B C   1 
ATOM   5879 O O   . GLY B 1 386 ? -17.460 -49.117 56.967 1.00 69.35  ? 412 GLY B O   1 
ATOM   5880 N N   . PHE B 1 387 ? -19.315 -48.430 55.892 1.00 66.63  ? 413 PHE B N   1 
ATOM   5881 C CA  . PHE B 1 387 ? -19.145 -47.059 56.361 1.00 63.90  ? 413 PHE B CA  1 
ATOM   5882 C C   . PHE B 1 387 ? -19.437 -46.940 57.849 1.00 63.35  ? 413 PHE B C   1 
ATOM   5883 O O   . PHE B 1 387 ? -18.773 -46.171 58.561 1.00 60.34  ? 413 PHE B O   1 
ATOM   5884 C CB  . PHE B 1 387 ? -20.058 -46.118 55.578 1.00 58.61  ? 413 PHE B CB  1 
ATOM   5885 C CG  . PHE B 1 387 ? -19.763 -44.672 55.818 1.00 59.81  ? 413 PHE B CG  1 
ATOM   5886 C CD1 . PHE B 1 387 ? -18.635 -44.076 55.248 1.00 60.97  ? 413 PHE B CD1 1 
ATOM   5887 C CD2 . PHE B 1 387 ? -20.597 -43.904 56.621 1.00 58.10  ? 413 PHE B CD2 1 
ATOM   5888 C CE1 . PHE B 1 387 ? -18.348 -42.728 55.475 1.00 62.60  ? 413 PHE B CE1 1 
ATOM   5889 C CE2 . PHE B 1 387 ? -20.316 -42.551 56.864 1.00 60.70  ? 413 PHE B CE2 1 
ATOM   5890 C CZ  . PHE B 1 387 ? -19.186 -41.965 56.296 1.00 60.74  ? 413 PHE B CZ  1 
ATOM   5891 N N   . THR B 1 388 ? -20.409 -47.709 58.341 1.00 61.78  ? 414 THR B N   1 
ATOM   5892 C CA  . THR B 1 388 ? -20.872 -47.567 59.718 1.00 62.89  ? 414 THR B CA  1 
ATOM   5893 C C   . THR B 1 388 ? -19.730 -47.761 60.710 1.00 60.23  ? 414 THR B C   1 
ATOM   5894 O O   . THR B 1 388 ? -18.893 -48.648 60.548 1.00 63.76  ? 414 THR B O   1 
ATOM   5895 C CB  . THR B 1 388 ? -21.998 -48.571 59.974 1.00 67.94  ? 414 THR B CB  1 
ATOM   5896 O OG1 . THR B 1 388 ? -23.016 -48.383 58.969 1.00 62.17  ? 414 THR B OG1 1 
ATOM   5897 C CG2 . THR B 1 388 ? -22.600 -48.399 61.383 1.00 60.35  ? 414 THR B CG2 1 
ATOM   5898 N N   . TYR B 1 389 ? -19.668 -46.878 61.709 1.00 57.65  ? 415 TYR B N   1 
ATOM   5899 C CA  . TYR B 1 389 ? -18.647 -46.926 62.756 1.00 56.52  ? 415 TYR B CA  1 
ATOM   5900 C C   . TYR B 1 389 ? -19.201 -46.297 64.026 1.00 63.12  ? 415 TYR B C   1 
ATOM   5901 O O   . TYR B 1 389 ? -19.778 -45.206 63.974 1.00 61.15  ? 415 TYR B O   1 
ATOM   5902 C CB  . TYR B 1 389 ? -17.367 -46.202 62.351 1.00 59.76  ? 415 TYR B CB  1 
ATOM   5903 C CG  . TYR B 1 389 ? -16.419 -45.953 63.527 1.00 65.10  ? 415 TYR B CG  1 
ATOM   5904 C CD1 . TYR B 1 389 ? -15.594 -46.964 64.016 1.00 61.58  ? 415 TYR B CD1 1 
ATOM   5905 C CD2 . TYR B 1 389 ? -16.347 -44.702 64.134 1.00 60.96  ? 415 TYR B CD2 1 
ATOM   5906 C CE1 . TYR B 1 389 ? -14.730 -46.726 65.091 1.00 69.61  ? 415 TYR B CE1 1 
ATOM   5907 C CE2 . TYR B 1 389 ? -15.497 -44.459 65.192 1.00 63.35  ? 415 TYR B CE2 1 
ATOM   5908 C CZ  . TYR B 1 389 ? -14.692 -45.468 65.676 1.00 67.75  ? 415 TYR B CZ  1 
ATOM   5909 O OH  . TYR B 1 389 ? -13.849 -45.191 66.744 1.00 72.49  ? 415 TYR B OH  1 
ATOM   5910 N N   . TYR B 1 390 ? -19.041 -46.983 65.156 1.00 63.73  ? 416 TYR B N   1 
ATOM   5911 C CA  . TYR B 1 390 ? -19.433 -46.452 66.458 1.00 65.95  ? 416 TYR B CA  1 
ATOM   5912 C C   . TYR B 1 390 ? -18.228 -46.507 67.384 1.00 61.77  ? 416 TYR B C   1 
ATOM   5913 O O   . TYR B 1 390 ? -17.698 -47.592 67.634 1.00 69.25  ? 416 TYR B O   1 
ATOM   5914 C CB  . TYR B 1 390 ? -20.604 -47.249 67.045 1.00 61.89  ? 416 TYR B CB  1 
ATOM   5915 C CG  . TYR B 1 390 ? -21.829 -47.258 66.140 1.00 65.41  ? 416 TYR B CG  1 
ATOM   5916 C CD1 . TYR B 1 390 ? -22.449 -46.074 65.777 1.00 65.73  ? 416 TYR B CD1 1 
ATOM   5917 C CD2 . TYR B 1 390 ? -22.362 -48.445 65.650 1.00 68.75  ? 416 TYR B CD2 1 
ATOM   5918 C CE1 . TYR B 1 390 ? -23.572 -46.062 64.942 1.00 71.05  ? 416 TYR B CE1 1 
ATOM   5919 C CE2 . TYR B 1 390 ? -23.491 -48.448 64.813 1.00 70.34  ? 416 TYR B CE2 1 
ATOM   5920 C CZ  . TYR B 1 390 ? -24.091 -47.249 64.464 1.00 71.34  ? 416 TYR B CZ  1 
ATOM   5921 O OH  . TYR B 1 390 ? -25.208 -47.206 63.636 1.00 74.35  ? 416 TYR B OH  1 
ATOM   5922 N N   . ARG B 1 391 ? -17.772 -45.340 67.855 1.00 61.31  ? 417 ARG B N   1 
ATOM   5923 C CA  . ARG B 1 391 ? -16.841 -45.285 68.985 1.00 67.76  ? 417 ARG B CA  1 
ATOM   5924 C C   . ARG B 1 391 ? -17.575 -45.777 70.227 1.00 69.13  ? 417 ARG B C   1 
ATOM   5925 O O   . ARG B 1 391 ? -17.096 -46.681 70.908 1.00 76.11  ? 417 ARG B O   1 
ATOM   5926 C CB  . ARG B 1 391 ? -16.295 -43.874 69.225 1.00 64.86  ? 417 ARG B CB  1 
HETATM 5927 C CAA . YEW C 2 .   ? -29.935 -23.160 18.750 1.00 53.51  ? 501 YEW A CAA 1 
HETATM 5928 C CAB . YEW C 2 .   ? -29.589 -23.896 19.882 1.00 56.92  ? 501 YEW A CAB 1 
HETATM 5929 C CAC . YEW C 2 .   ? -28.560 -23.462 20.761 1.00 61.44  ? 501 YEW A CAC 1 
HETATM 5930 C CAD . YEW C 2 .   ? -27.872 -22.309 20.482 1.00 60.27  ? 501 YEW A CAD 1 
HETATM 5931 C CAE . YEW C 2 .   ? -28.201 -21.561 19.332 1.00 54.13  ? 501 YEW A CAE 1 
HETATM 5932 C CAF . YEW C 2 .   ? -29.210 -22.001 18.489 1.00 51.89  ? 501 YEW A CAF 1 
HETATM 5933 C CAG . YEW C 2 .   ? -28.209 -24.195 21.938 1.00 60.44  ? 501 YEW A CAG 1 
HETATM 5934 C CAH . YEW C 2 .   ? -27.181 -23.683 22.733 1.00 62.01  ? 501 YEW A CAH 1 
HETATM 5935 C CAJ . YEW C 2 .   ? -26.844 -21.848 21.352 1.00 57.98  ? 501 YEW A CAJ 1 
HETATM 5936 C CAK . YEW C 2 .   ? -25.462 -22.021 23.279 1.00 64.18  ? 501 YEW A CAK 1 
HETATM 5937 C CAL . YEW C 2 .   ? -25.957 -20.860 24.152 1.00 64.77  ? 501 YEW A CAL 1 
HETATM 5938 C CAM . YEW C 2 .   ? -27.312 -20.668 24.398 1.00 54.10  ? 501 YEW A CAM 1 
HETATM 5939 C CAN . YEW C 2 .   ? -27.725 -19.602 25.181 1.00 58.17  ? 501 YEW A CAN 1 
HETATM 5940 C CAO . YEW C 2 .   ? -26.812 -18.713 25.735 1.00 61.50  ? 501 YEW A CAO 1 
HETATM 5941 C CAP . YEW C 2 .   ? -25.454 -18.898 25.472 1.00 59.65  ? 501 YEW A CAP 1 
HETATM 5942 C CAQ . YEW C 2 .   ? -25.039 -19.969 24.698 1.00 56.73  ? 501 YEW A CAQ 1 
HETATM 5943 C CAR . YEW C 2 .   ? -24.405 -17.950 26.075 1.00 64.11  ? 501 YEW A CAR 1 
HETATM 5944 C CAT . YEW C 2 .   ? -22.121 -16.889 25.962 1.00 57.16  ? 501 YEW A CAT 1 
HETATM 5945 C CAU . YEW C 2 .   ? -31.036 -23.583 17.739 1.00 53.27  ? 501 YEW A CAU 1 
HETATM 5946 C CAX . YEW C 2 .   ? -32.316 -23.710 15.908 1.00 65.22  ? 501 YEW A CAX 1 
HETATM 5947 C CAY . YEW C 2 .   ? -31.241 -22.974 16.466 1.00 45.88  ? 501 YEW A CAY 1 
HETATM 5948 C CAZ . YEW C 2 .   ? -32.106 -25.478 18.919 1.00 63.24  ? 501 YEW A CAZ 1 
HETATM 5949 N NAI . YEW C 2 .   ? -26.533 -22.548 22.421 1.00 65.05  ? 501 YEW A NAI 1 
HETATM 5950 N NAS . YEW C 2 .   ? -23.136 -17.764 25.399 1.00 61.54  ? 501 YEW A NAS 1 
HETATM 5951 N NAV . YEW C 2 .   ? -31.919 -24.576 17.817 1.00 58.40  ? 501 YEW A NAV 1 
HETATM 5952 N NAW . YEW C 2 .   ? -32.696 -24.652 16.754 1.00 51.95  ? 501 YEW A NAW 1 
HETATM 5953 O OBA . YEW C 2 .   ? -26.126 -20.688 21.082 1.00 57.29  ? 501 YEW A OBA 1 
HETATM 5954 O OBB . YEW C 2 .   ? -24.617 -17.390 27.102 1.00 64.96  ? 501 YEW A OBB 1 
HETATM 5955 S S   . SO4 D 3 .   ? -41.200 -32.246 4.168  1.00 76.74  ? 502 SO4 A S   1 
HETATM 5956 O O1  . SO4 D 3 .   ? -39.829 -32.122 3.655  1.00 81.40  ? 502 SO4 A O1  1 
HETATM 5957 O O2  . SO4 D 3 .   ? -42.099 -31.794 3.093  1.00 70.00  ? 502 SO4 A O2  1 
HETATM 5958 O O3  . SO4 D 3 .   ? -41.478 -33.619 4.630  1.00 61.33  ? 502 SO4 A O3  1 
HETATM 5959 O O4  . SO4 D 3 .   ? -41.399 -31.356 5.300  1.00 68.47  ? 502 SO4 A O4  1 
HETATM 5960 C CAA . YEW E 2 .   ? -16.249 -29.195 59.827 1.00 63.72  ? 501 YEW B CAA 1 
HETATM 5961 C CAB . YEW E 2 .   ? -16.463 -28.280 58.789 1.00 68.42  ? 501 YEW B CAB 1 
HETATM 5962 C CAC . YEW E 2 .   ? -16.347 -28.667 57.431 1.00 66.22  ? 501 YEW B CAC 1 
HETATM 5963 C CAD . YEW E 2 .   ? -16.001 -29.952 57.128 1.00 68.62  ? 501 YEW B CAD 1 
HETATM 5964 C CAE . YEW E 2 .   ? -15.764 -30.894 58.170 1.00 61.49  ? 501 YEW B CAE 1 
HETATM 5965 C CAF . YEW E 2 .   ? -15.894 -30.507 59.495 1.00 61.69  ? 501 YEW B CAF 1 
HETATM 5966 C CAG . YEW E 2 .   ? -16.564 -27.745 56.360 1.00 69.14  ? 501 YEW B CAG 1 
HETATM 5967 C CAH . YEW E 2 .   ? -16.417 -28.204 55.053 1.00 65.56  ? 501 YEW B CAH 1 
HETATM 5968 C CAJ . YEW E 2 .   ? -15.874 -30.348 55.766 1.00 67.24  ? 501 YEW B CAJ 1 
HETATM 5969 C CAK . YEW E 2 .   ? -15.948 -29.922 53.431 1.00 66.67  ? 501 YEW B CAK 1 
HETATM 5970 C CAL . YEW E 2 .   ? -17.176 -30.654 52.898 1.00 67.68  ? 501 YEW B CAL 1 
HETATM 5971 C CAM . YEW E 2 .   ? -18.418 -30.538 53.510 1.00 62.96  ? 501 YEW B CAM 1 
HETATM 5972 C CAN . YEW E 2 .   ? -19.512 -31.209 52.981 1.00 65.94  ? 501 YEW B CAN 1 
HETATM 5973 C CAO . YEW E 2 .   ? -19.373 -31.968 51.827 1.00 71.22  ? 501 YEW B CAO 1 
HETATM 5974 C CAP . YEW E 2 .   ? -18.136 -32.062 51.201 1.00 72.04  ? 501 YEW B CAP 1 
HETATM 5975 C CAQ . YEW E 2 .   ? -17.043 -31.409 51.748 1.00 67.99  ? 501 YEW B CAQ 1 
HETATM 5976 C CAR . YEW E 2 .   ? -17.963 -32.878 49.909 1.00 75.12  ? 501 YEW B CAR 1 
HETATM 5977 C CAT . YEW E 2 .   ? -16.492 -34.170 48.322 1.00 73.33  ? 501 YEW B CAT 1 
HETATM 5978 C CAU . YEW E 2 .   ? -16.372 -28.842 61.325 1.00 64.64  ? 501 YEW B CAU 1 
HETATM 5979 C CAX . YEW E 2 .   ? -16.234 -28.962 63.553 1.00 63.32  ? 501 YEW B CAX 1 
HETATM 5980 C CAY . YEW E 2 .   ? -15.922 -29.669 62.381 1.00 48.15  ? 501 YEW B CAY 1 
HETATM 5981 C CAZ . YEW E 2 .   ? -17.526 -26.666 61.232 1.00 70.58  ? 501 YEW B CAZ 1 
HETATM 5982 N NAI . YEW E 2 .   ? -16.097 -29.474 54.804 1.00 69.06  ? 501 YEW B NAI 1 
HETATM 5983 N NAS . YEW E 2 .   ? -16.659 -33.414 49.552 1.00 73.37  ? 501 YEW B NAS 1 
HETATM 5984 N NAV . YEW E 2 .   ? -16.905 -27.783 61.900 1.00 68.60  ? 501 YEW B NAV 1 
HETATM 5985 N NAW . YEW E 2 .   ? -16.824 -27.849 63.218 1.00 60.02  ? 501 YEW B NAW 1 
HETATM 5986 O OBA . YEW E 2 .   ? -15.536 -31.663 55.440 1.00 70.47  ? 501 YEW B OBA 1 
HETATM 5987 O OBB . YEW E 2 .   ? -18.898 -33.049 49.187 1.00 76.89  ? 501 YEW B OBB 1 
HETATM 5988 O O   . HOH F 4 .   ? -42.660 -28.787 20.600 1.00 72.46  ? 601 HOH A O   1 
HETATM 5989 O O   . HOH F 4 .   ? -28.628 1.745   34.019 1.00 76.71  ? 602 HOH A O   1 
HETATM 5990 O O   . HOH F 4 .   ? -38.071 -31.152 23.685 1.00 78.82  ? 603 HOH A O   1 
HETATM 5991 O O   . HOH F 4 .   ? -28.355 -36.626 9.702  1.00 53.59  ? 604 HOH A O   1 
HETATM 5992 O O   . HOH F 4 .   ? 3.198   -21.661 16.271 1.00 85.78  ? 605 HOH A O   1 
HETATM 5993 O O   . HOH F 4 .   ? -27.605 -27.819 21.654 1.00 61.84  ? 606 HOH A O   1 
HETATM 5994 O O   . HOH F 4 .   ? -4.807  -18.841 9.949  1.00 65.93  ? 607 HOH A O   1 
HETATM 5995 O O   . HOH F 4 .   ? -28.516 4.809   34.546 1.00 76.79  ? 608 HOH A O   1 
HETATM 5996 O O   . HOH F 4 .   ? -39.517 -7.671  24.272 1.00 66.02  ? 609 HOH A O   1 
HETATM 5997 O O   . HOH F 4 .   ? -30.705 -8.687  32.436 1.00 69.75  ? 610 HOH A O   1 
HETATM 5998 O O   . HOH F 4 .   ? -28.829 -21.405 6.513  1.00 55.84  ? 611 HOH A O   1 
HETATM 5999 O O   . HOH F 4 .   ? -30.743 -31.927 20.348 1.00 61.09  ? 612 HOH A O   1 
HETATM 6000 O O   . HOH F 4 .   ? -47.873 -23.052 18.177 1.00 78.14  ? 613 HOH A O   1 
HETATM 6001 O O   . HOH F 4 .   ? -15.484 -26.362 22.219 1.00 65.42  ? 614 HOH A O   1 
HETATM 6002 O O   . HOH F 4 .   ? -4.346  -32.456 -3.456 1.00 55.64  ? 615 HOH A O   1 
HETATM 6003 O O   . HOH F 4 .   ? -6.709  -17.505 23.239 1.00 61.17  ? 616 HOH A O   1 
HETATM 6004 O O   . HOH F 4 .   ? -23.043 -17.493 22.514 1.00 59.88  ? 617 HOH A O   1 
HETATM 6005 O O   . HOH F 4 .   ? -31.207 -25.940 5.356  1.00 58.93  ? 618 HOH A O   1 
HETATM 6006 O O   . HOH F 4 .   ? -10.137 -23.407 6.349  1.00 62.15  ? 619 HOH A O   1 
HETATM 6007 O O   . HOH F 4 .   ? -19.266 -20.672 21.262 1.00 66.22  ? 620 HOH A O   1 
HETATM 6008 O O   . HOH F 4 .   ? -17.673 -9.780  25.817 1.00 70.96  ? 621 HOH A O   1 
HETATM 6009 O O   . HOH F 4 .   ? -19.924 -22.891 24.791 1.00 70.16  ? 622 HOH A O   1 
HETATM 6010 O O   . HOH F 4 .   ? -15.923 -29.946 28.212 1.00 69.52  ? 623 HOH A O   1 
HETATM 6011 O O   . HOH F 4 .   ? -26.963 -15.775 6.993  1.00 57.91  ? 624 HOH A O   1 
HETATM 6012 O O   . HOH F 4 .   ? -51.653 -17.809 20.514 1.00 78.16  ? 625 HOH A O   1 
HETATM 6013 O O   . HOH F 4 .   ? -9.329  -30.969 23.657 1.00 52.43  ? 626 HOH A O   1 
HETATM 6014 O O   . HOH F 4 .   ? -26.180 -2.704  12.585 1.00 80.54  ? 627 HOH A O   1 
HETATM 6015 O O   . HOH F 4 .   ? -22.824 -29.231 -0.746 1.00 61.26  ? 628 HOH A O   1 
HETATM 6016 O O   . HOH F 4 .   ? -37.634 -19.948 30.631 1.00 78.10  ? 629 HOH A O   1 
HETATM 6017 O O   . HOH F 4 .   ? -42.073 -21.286 10.180 1.00 70.64  ? 630 HOH A O   1 
HETATM 6018 O O   . HOH F 4 .   ? -30.112 -34.950 17.000 1.00 55.84  ? 631 HOH A O   1 
HETATM 6019 O O   . HOH F 4 .   ? -13.263 -24.824 17.536 1.00 60.76  ? 632 HOH A O   1 
HETATM 6020 O O   . HOH F 4 .   ? -13.699 -34.157 30.676 1.00 71.23  ? 633 HOH A O   1 
HETATM 6021 O O   . HOH F 4 .   ? -35.296 -3.617  19.975 1.00 55.40  ? 634 HOH A O   1 
HETATM 6022 O O   . HOH F 4 .   ? -37.402 -21.421 11.291 1.00 60.31  ? 635 HOH A O   1 
HETATM 6023 O O   . HOH F 4 .   ? -0.319  -20.207 22.660 1.00 64.08  ? 636 HOH A O   1 
HETATM 6024 O O   . HOH F 4 .   ? -26.602 -18.206 6.801  1.00 57.44  ? 637 HOH A O   1 
HETATM 6025 O O   . HOH F 4 .   ? -37.357 -32.036 17.112 1.00 52.27  ? 638 HOH A O   1 
HETATM 6026 O O   . HOH F 4 .   ? -33.231 -13.133 4.581  1.00 85.10  ? 639 HOH A O   1 
HETATM 6027 O O   . HOH F 4 .   ? -17.793 -19.531 18.543 1.00 64.63  ? 640 HOH A O   1 
HETATM 6028 O O   . HOH F 4 .   ? -14.958 -28.210 -0.987 1.00 71.41  ? 641 HOH A O   1 
HETATM 6029 O O   . HOH F 4 .   ? -28.300 -27.366 1.039  1.00 59.63  ? 642 HOH A O   1 
HETATM 6030 O O   . HOH F 4 .   ? -18.479 -48.832 11.184 1.00 71.25  ? 643 HOH A O   1 
HETATM 6031 O O   . HOH F 4 .   ? 0.280   -33.412 6.552  1.00 79.18  ? 644 HOH A O   1 
HETATM 6032 O O   . HOH F 4 .   ? -29.868 -24.344 3.340  1.00 74.21  ? 645 HOH A O   1 
HETATM 6033 O O   . HOH F 4 .   ? -20.407 -45.369 18.578 1.00 77.25  ? 646 HOH A O   1 
HETATM 6034 O O   . HOH F 4 .   ? -26.726 -46.029 6.308  1.00 78.36  ? 647 HOH A O   1 
HETATM 6035 O O   . HOH F 4 .   ? -28.629 -18.989 4.768  1.00 64.46  ? 648 HOH A O   1 
HETATM 6036 O O   . HOH F 4 .   ? -42.319 -12.348 11.228 1.00 71.28  ? 649 HOH A O   1 
HETATM 6037 O O   . HOH F 4 .   ? -39.522 -19.687 9.295  1.00 73.54  ? 650 HOH A O   1 
HETATM 6038 O O   . HOH F 4 .   ? -17.747 -16.116 25.038 1.00 97.04  ? 651 HOH A O   1 
HETATM 6039 O O   . HOH F 4 .   ? -29.458 -16.601 32.668 1.00 79.71  ? 652 HOH A O   1 
HETATM 6040 O O   . HOH F 4 .   ? -8.117  -16.899 3.495  1.00 86.27  ? 653 HOH A O   1 
HETATM 6041 O O   . HOH F 4 .   ? -1.665  -42.519 19.299 1.00 82.10  ? 654 HOH A O   1 
HETATM 6042 O O   . HOH G 4 .   ? -6.187  -18.860 67.250 1.00 59.17  ? 601 HOH B O   1 
HETATM 6043 O O   . HOH G 4 .   ? 1.629   -19.199 71.598 1.00 65.87  ? 602 HOH B O   1 
HETATM 6044 O O   . HOH G 4 .   ? -2.642  -9.891  56.136 1.00 84.70  ? 603 HOH B O   1 
HETATM 6045 O O   . HOH G 4 .   ? -29.698 -49.818 44.429 1.00 87.07  ? 604 HOH B O   1 
HETATM 6046 O O   . HOH G 4 .   ? -15.642 -20.368 59.913 1.00 65.58  ? 605 HOH B O   1 
HETATM 6047 O O   . HOH G 4 .   ? -1.787  -30.116 50.423 1.00 74.60  ? 606 HOH B O   1 
HETATM 6048 O O   . HOH G 4 .   ? -15.061 -34.248 51.407 1.00 80.05  ? 607 HOH B O   1 
HETATM 6049 O O   . HOH G 4 .   ? -13.043 -42.238 67.118 1.00 67.15  ? 608 HOH B O   1 
HETATM 6050 O O   . HOH G 4 .   ? -25.285 -47.093 59.447 1.00 64.28  ? 609 HOH B O   1 
HETATM 6051 O O   . HOH G 4 .   ? -29.699 -44.619 59.740 1.00 62.85  ? 610 HOH B O   1 
HETATM 6052 O O   . HOH G 4 .   ? -26.461 -50.235 54.933 1.00 74.31  ? 611 HOH B O   1 
HETATM 6053 O O   . HOH G 4 .   ? 4.101   -16.692 67.390 1.00 66.29  ? 612 HOH B O   1 
HETATM 6054 O O   . HOH G 4 .   ? -1.287  -23.281 44.267 1.00 59.74  ? 613 HOH B O   1 
HETATM 6055 O O   . HOH G 4 .   ? -6.911  -25.353 46.128 1.00 61.32  ? 614 HOH B O   1 
HETATM 6056 O O   . HOH G 4 .   ? -18.366 -31.822 69.823 1.00 52.58  ? 615 HOH B O   1 
HETATM 6057 O O   . HOH G 4 .   ? -18.462 -19.844 66.783 1.00 68.57  ? 616 HOH B O   1 
HETATM 6058 O O   . HOH G 4 .   ? -4.894  -20.718 73.675 1.00 64.52  ? 617 HOH B O   1 
HETATM 6059 O O   . HOH G 4 .   ? 7.073   -22.277 36.516 1.00 81.13  ? 618 HOH B O   1 
HETATM 6060 O O   . HOH G 4 .   ? -6.564  -26.070 76.373 1.00 76.09  ? 619 HOH B O   1 
HETATM 6061 O O   . HOH G 4 .   ? -0.435  -29.991 46.416 1.00 59.83  ? 620 HOH B O   1 
HETATM 6062 O O   . HOH G 4 .   ? -13.751 -20.139 35.893 1.00 71.88  ? 621 HOH B O   1 
HETATM 6063 O O   . HOH G 4 .   ? -25.566 -26.290 52.016 1.00 85.36  ? 622 HOH B O   1 
HETATM 6064 O O   . HOH G 4 .   ? 1.890   -19.056 76.174 1.00 68.56  ? 623 HOH B O   1 
HETATM 6065 O O   . HOH G 4 .   ? 4.321   -9.209  64.414 1.00 74.73  ? 624 HOH B O   1 
HETATM 6066 O O   . HOH G 4 .   ? 3.217   -7.347  61.772 1.00 81.01  ? 625 HOH B O   1 
HETATM 6067 O O   . HOH G 4 .   ? -34.286 -70.963 56.233 1.00 76.79  ? 626 HOH B O   1 
# 
