data_8X6U
# 
_entry.id   8X6U 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8X6U         pdb_00008x6u 10.2210/pdb8x6u/pdb 
WWPDB D_1300042738 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8X6U 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              huangy@shsmu.edu.cn 
_pdbx_contact_author.name_first         Ying 
_pdbx_contact_author.name_last          Huang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2806-2874 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Jiang, L.' 1 0009-0005-7089-4980 
'Huang, Y.' 2 0000-0002-2806-2874 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of EfCDA in complex with dFdU' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Jiang, L.' 1 0009-0005-7089-4980 
primary 'Huang, Y.' 2 0000-0002-2806-2874 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man EfCDA                        14488.424 2   ? ? ? WP_002291109.1 
2 non-polymer syn 'ZINC ION'                   65.409    2   ? ? ? ?              
3 non-polymer syn "2',2'-Difluorodeoxyuridine" 264.183   2   ? ? ? ?              
4 water       nat water                        18.015    323 ? ? ? ?              
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GSMAELKQEWINTAIEALDKAYVPYSHFPVGACLVTESGKIYQGINIENASFGLTNCAERTAFFKAVSEGERSFTHLVVA
GHTPDPISPCGACRQVMAEFCAPDMPVTLVGDNGVTKATTVRELLPYAFTEKDL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSMAELKQEWINTAIEALDKAYVPYSHFPVGACLVTESGKIYQGINIENASFGLTNCAERTAFFKAVSEGERSFTHLVVA
GHTPDPISPCGACRQVMAEFCAPDMPVTLVGDNGVTKATTVRELLPYAFTEKDL
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                   ZN  
3 "2',2'-Difluorodeoxyuridine" Y7U 
4 water                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   MET n 
1 4   ALA n 
1 5   GLU n 
1 6   LEU n 
1 7   LYS n 
1 8   GLN n 
1 9   GLU n 
1 10  TRP n 
1 11  ILE n 
1 12  ASN n 
1 13  THR n 
1 14  ALA n 
1 15  ILE n 
1 16  GLU n 
1 17  ALA n 
1 18  LEU n 
1 19  ASP n 
1 20  LYS n 
1 21  ALA n 
1 22  TYR n 
1 23  VAL n 
1 24  PRO n 
1 25  TYR n 
1 26  SER n 
1 27  HIS n 
1 28  PHE n 
1 29  PRO n 
1 30  VAL n 
1 31  GLY n 
1 32  ALA n 
1 33  CYS n 
1 34  LEU n 
1 35  VAL n 
1 36  THR n 
1 37  GLU n 
1 38  SER n 
1 39  GLY n 
1 40  LYS n 
1 41  ILE n 
1 42  TYR n 
1 43  GLN n 
1 44  GLY n 
1 45  ILE n 
1 46  ASN n 
1 47  ILE n 
1 48  GLU n 
1 49  ASN n 
1 50  ALA n 
1 51  SER n 
1 52  PHE n 
1 53  GLY n 
1 54  LEU n 
1 55  THR n 
1 56  ASN n 
1 57  CYS n 
1 58  ALA n 
1 59  GLU n 
1 60  ARG n 
1 61  THR n 
1 62  ALA n 
1 63  PHE n 
1 64  PHE n 
1 65  LYS n 
1 66  ALA n 
1 67  VAL n 
1 68  SER n 
1 69  GLU n 
1 70  GLY n 
1 71  GLU n 
1 72  ARG n 
1 73  SER n 
1 74  PHE n 
1 75  THR n 
1 76  HIS n 
1 77  LEU n 
1 78  VAL n 
1 79  VAL n 
1 80  ALA n 
1 81  GLY n 
1 82  HIS n 
1 83  THR n 
1 84  PRO n 
1 85  ASP n 
1 86  PRO n 
1 87  ILE n 
1 88  SER n 
1 89  PRO n 
1 90  CYS n 
1 91  GLY n 
1 92  ALA n 
1 93  CYS n 
1 94  ARG n 
1 95  GLN n 
1 96  VAL n 
1 97  MET n 
1 98  ALA n 
1 99  GLU n 
1 100 PHE n 
1 101 CYS n 
1 102 ALA n 
1 103 PRO n 
1 104 ASP n 
1 105 MET n 
1 106 PRO n 
1 107 VAL n 
1 108 THR n 
1 109 LEU n 
1 110 VAL n 
1 111 GLY n 
1 112 ASP n 
1 113 ASN n 
1 114 GLY n 
1 115 VAL n 
1 116 THR n 
1 117 LYS n 
1 118 ALA n 
1 119 THR n 
1 120 THR n 
1 121 VAL n 
1 122 ARG n 
1 123 GLU n 
1 124 LEU n 
1 125 LEU n 
1 126 PRO n 
1 127 TYR n 
1 128 ALA n 
1 129 PHE n 
1 130 THR n 
1 131 GLU n 
1 132 LYS n 
1 133 ASP n 
1 134 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   134 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      Enterococcus 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1350 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                      ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                     ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                   ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'              ? 'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE                     ? 'C3 H7 N O2 S'    121.158 
GLN 'L-peptide linking' y GLUTAMINE                    ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'              ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                      ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                    ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                        ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                   ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                      ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                       ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                   ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                      ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                       ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                    ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                   ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                     ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                       ? 'C5 H11 N O2'     117.146 
Y7U non-polymer         . "2',2'-Difluorodeoxyuridine" 
'1-[(2~{R},4~{R},5~{R})-3,3-bis(fluoranyl)-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]pyrimidine-2,4-dione' 'C9 H10 F2 N2 O5' 
264.183 
ZN  non-polymer         . 'ZINC ION'                   ? 'Zn 2'            65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -1  ?   ?   ?   A . n 
A 1 2   SER 2   0   0   SER SER A . n 
A 1 3   MET 3   1   1   MET MET A . n 
A 1 4   ALA 4   2   2   ALA ALA A . n 
A 1 5   GLU 5   3   3   GLU GLU A . n 
A 1 6   LEU 6   4   4   LEU LEU A . n 
A 1 7   LYS 7   5   5   LYS LYS A . n 
A 1 8   GLN 8   6   6   GLN GLN A . n 
A 1 9   GLU 9   7   7   GLU GLU A . n 
A 1 10  TRP 10  8   8   TRP TRP A . n 
A 1 11  ILE 11  9   9   ILE ILE A . n 
A 1 12  ASN 12  10  10  ASN ASN A . n 
A 1 13  THR 13  11  11  THR THR A . n 
A 1 14  ALA 14  12  12  ALA ALA A . n 
A 1 15  ILE 15  13  13  ILE ILE A . n 
A 1 16  GLU 16  14  14  GLU GLU A . n 
A 1 17  ALA 17  15  15  ALA ALA A . n 
A 1 18  LEU 18  16  16  LEU LEU A . n 
A 1 19  ASP 19  17  17  ASP ASP A . n 
A 1 20  LYS 20  18  18  LYS LYS A . n 
A 1 21  ALA 21  19  19  ALA ALA A . n 
A 1 22  TYR 22  20  20  TYR TYR A . n 
A 1 23  VAL 23  21  21  VAL VAL A . n 
A 1 24  PRO 24  22  22  PRO PRO A . n 
A 1 25  TYR 25  23  23  TYR TYR A . n 
A 1 26  SER 26  24  24  SER SER A . n 
A 1 27  HIS 27  25  25  HIS HIS A . n 
A 1 28  PHE 28  26  26  PHE PHE A . n 
A 1 29  PRO 29  27  27  PRO PRO A . n 
A 1 30  VAL 30  28  28  VAL VAL A . n 
A 1 31  GLY 31  29  29  GLY GLY A . n 
A 1 32  ALA 32  30  30  ALA ALA A . n 
A 1 33  CYS 33  31  31  CYS CYS A . n 
A 1 34  LEU 34  32  32  LEU LEU A . n 
A 1 35  VAL 35  33  33  VAL VAL A . n 
A 1 36  THR 36  34  34  THR THR A . n 
A 1 37  GLU 37  35  35  GLU GLU A . n 
A 1 38  SER 38  36  36  SER SER A . n 
A 1 39  GLY 39  37  37  GLY GLY A . n 
A 1 40  LYS 40  38  38  LYS LYS A . n 
A 1 41  ILE 41  39  39  ILE ILE A . n 
A 1 42  TYR 42  40  40  TYR TYR A . n 
A 1 43  GLN 43  41  41  GLN GLN A . n 
A 1 44  GLY 44  42  42  GLY GLY A . n 
A 1 45  ILE 45  43  43  ILE ILE A . n 
A 1 46  ASN 46  44  44  ASN ASN A . n 
A 1 47  ILE 47  45  45  ILE ILE A . n 
A 1 48  GLU 48  46  46  GLU GLU A . n 
A 1 49  ASN 49  47  47  ASN ASN A . n 
A 1 50  ALA 50  48  48  ALA ALA A . n 
A 1 51  SER 51  49  49  SER SER A . n 
A 1 52  PHE 52  50  50  PHE PHE A . n 
A 1 53  GLY 53  51  51  GLY GLY A . n 
A 1 54  LEU 54  52  52  LEU LEU A . n 
A 1 55  THR 55  53  53  THR THR A . n 
A 1 56  ASN 56  54  54  ASN ASN A . n 
A 1 57  CYS 57  55  55  CYS CYS A . n 
A 1 58  ALA 58  56  56  ALA ALA A . n 
A 1 59  GLU 59  57  57  GLU GLU A . n 
A 1 60  ARG 60  58  58  ARG ARG A . n 
A 1 61  THR 61  59  59  THR THR A . n 
A 1 62  ALA 62  60  60  ALA ALA A . n 
A 1 63  PHE 63  61  61  PHE PHE A . n 
A 1 64  PHE 64  62  62  PHE PHE A . n 
A 1 65  LYS 65  63  63  LYS LYS A . n 
A 1 66  ALA 66  64  64  ALA ALA A . n 
A 1 67  VAL 67  65  65  VAL VAL A . n 
A 1 68  SER 68  66  66  SER SER A . n 
A 1 69  GLU 69  67  67  GLU GLU A . n 
A 1 70  GLY 70  68  68  GLY GLY A . n 
A 1 71  GLU 71  69  69  GLU GLU A . n 
A 1 72  ARG 72  70  70  ARG ARG A . n 
A 1 73  SER 73  71  71  SER SER A . n 
A 1 74  PHE 74  72  72  PHE PHE A . n 
A 1 75  THR 75  73  73  THR THR A . n 
A 1 76  HIS 76  74  74  HIS HIS A . n 
A 1 77  LEU 77  75  75  LEU LEU A . n 
A 1 78  VAL 78  76  76  VAL VAL A . n 
A 1 79  VAL 79  77  77  VAL VAL A . n 
A 1 80  ALA 80  78  78  ALA ALA A . n 
A 1 81  GLY 81  79  79  GLY GLY A . n 
A 1 82  HIS 82  80  80  HIS HIS A . n 
A 1 83  THR 83  81  81  THR THR A . n 
A 1 84  PRO 84  82  82  PRO PRO A . n 
A 1 85  ASP 85  83  83  ASP ASP A . n 
A 1 86  PRO 86  84  84  PRO PRO A . n 
A 1 87  ILE 87  85  85  ILE ILE A . n 
A 1 88  SER 88  86  86  SER SER A . n 
A 1 89  PRO 89  87  87  PRO PRO A . n 
A 1 90  CYS 90  88  88  CYS CYS A . n 
A 1 91  GLY 91  89  89  GLY GLY A . n 
A 1 92  ALA 92  90  90  ALA ALA A . n 
A 1 93  CYS 93  91  91  CYS CYS A . n 
A 1 94  ARG 94  92  92  ARG ARG A . n 
A 1 95  GLN 95  93  93  GLN GLN A . n 
A 1 96  VAL 96  94  94  VAL VAL A . n 
A 1 97  MET 97  95  95  MET MET A . n 
A 1 98  ALA 98  96  96  ALA ALA A . n 
A 1 99  GLU 99  97  97  GLU GLU A . n 
A 1 100 PHE 100 98  98  PHE PHE A . n 
A 1 101 CYS 101 99  99  CYS CYS A . n 
A 1 102 ALA 102 100 100 ALA ALA A . n 
A 1 103 PRO 103 101 101 PRO PRO A . n 
A 1 104 ASP 104 102 102 ASP ASP A . n 
A 1 105 MET 105 103 103 MET MET A . n 
A 1 106 PRO 106 104 104 PRO PRO A . n 
A 1 107 VAL 107 105 105 VAL VAL A . n 
A 1 108 THR 108 106 106 THR THR A . n 
A 1 109 LEU 109 107 107 LEU LEU A . n 
A 1 110 VAL 110 108 108 VAL VAL A . n 
A 1 111 GLY 111 109 109 GLY GLY A . n 
A 1 112 ASP 112 110 110 ASP ASP A . n 
A 1 113 ASN 113 111 111 ASN ASN A . n 
A 1 114 GLY 114 112 112 GLY GLY A . n 
A 1 115 VAL 115 113 113 VAL VAL A . n 
A 1 116 THR 116 114 114 THR THR A . n 
A 1 117 LYS 117 115 115 LYS LYS A . n 
A 1 118 ALA 118 116 116 ALA ALA A . n 
A 1 119 THR 119 117 117 THR THR A . n 
A 1 120 THR 120 118 118 THR THR A . n 
A 1 121 VAL 121 119 119 VAL VAL A . n 
A 1 122 ARG 122 120 120 ARG ARG A . n 
A 1 123 GLU 123 121 121 GLU GLU A . n 
A 1 124 LEU 124 122 122 LEU LEU A . n 
A 1 125 LEU 125 123 123 LEU LEU A . n 
A 1 126 PRO 126 124 124 PRO PRO A . n 
A 1 127 TYR 127 125 125 TYR TYR A . n 
A 1 128 ALA 128 126 126 ALA ALA A . n 
A 1 129 PHE 129 127 127 PHE PHE A . n 
A 1 130 THR 130 128 128 THR THR A . n 
A 1 131 GLU 131 129 129 GLU GLU A . n 
A 1 132 LYS 132 130 130 LYS LYS A . n 
A 1 133 ASP 133 131 131 ASP ASP A . n 
A 1 134 LEU 134 132 132 LEU LEU A . n 
B 1 1   GLY 1   -1  ?   ?   ?   B . n 
B 1 2   SER 2   0   ?   ?   ?   B . n 
B 1 3   MET 3   1   ?   ?   ?   B . n 
B 1 4   ALA 4   2   2   ALA ALA B . n 
B 1 5   GLU 5   3   3   GLU GLU B . n 
B 1 6   LEU 6   4   4   LEU LEU B . n 
B 1 7   LYS 7   5   5   LYS LYS B . n 
B 1 8   GLN 8   6   6   GLN GLN B . n 
B 1 9   GLU 9   7   7   GLU GLU B . n 
B 1 10  TRP 10  8   8   TRP TRP B . n 
B 1 11  ILE 11  9   9   ILE ILE B . n 
B 1 12  ASN 12  10  10  ASN ASN B . n 
B 1 13  THR 13  11  11  THR THR B . n 
B 1 14  ALA 14  12  12  ALA ALA B . n 
B 1 15  ILE 15  13  13  ILE ILE B . n 
B 1 16  GLU 16  14  14  GLU GLU B . n 
B 1 17  ALA 17  15  15  ALA ALA B . n 
B 1 18  LEU 18  16  16  LEU LEU B . n 
B 1 19  ASP 19  17  17  ASP ASP B . n 
B 1 20  LYS 20  18  18  LYS LYS B . n 
B 1 21  ALA 21  19  19  ALA ALA B . n 
B 1 22  TYR 22  20  20  TYR TYR B . n 
B 1 23  VAL 23  21  21  VAL VAL B . n 
B 1 24  PRO 24  22  22  PRO PRO B . n 
B 1 25  TYR 25  23  23  TYR TYR B . n 
B 1 26  SER 26  24  24  SER SER B . n 
B 1 27  HIS 27  25  25  HIS HIS B . n 
B 1 28  PHE 28  26  26  PHE PHE B . n 
B 1 29  PRO 29  27  27  PRO PRO B . n 
B 1 30  VAL 30  28  28  VAL VAL B . n 
B 1 31  GLY 31  29  29  GLY GLY B . n 
B 1 32  ALA 32  30  30  ALA ALA B . n 
B 1 33  CYS 33  31  31  CYS CYS B . n 
B 1 34  LEU 34  32  32  LEU LEU B . n 
B 1 35  VAL 35  33  33  VAL VAL B . n 
B 1 36  THR 36  34  34  THR THR B . n 
B 1 37  GLU 37  35  35  GLU GLU B . n 
B 1 38  SER 38  36  36  SER SER B . n 
B 1 39  GLY 39  37  37  GLY GLY B . n 
B 1 40  LYS 40  38  38  LYS LYS B . n 
B 1 41  ILE 41  39  39  ILE ILE B . n 
B 1 42  TYR 42  40  40  TYR TYR B . n 
B 1 43  GLN 43  41  41  GLN GLN B . n 
B 1 44  GLY 44  42  42  GLY GLY B . n 
B 1 45  ILE 45  43  43  ILE ILE B . n 
B 1 46  ASN 46  44  44  ASN ASN B . n 
B 1 47  ILE 47  45  45  ILE ILE B . n 
B 1 48  GLU 48  46  46  GLU GLU B . n 
B 1 49  ASN 49  47  47  ASN ASN B . n 
B 1 50  ALA 50  48  48  ALA ALA B . n 
B 1 51  SER 51  49  49  SER SER B . n 
B 1 52  PHE 52  50  50  PHE PHE B . n 
B 1 53  GLY 53  51  51  GLY GLY B . n 
B 1 54  LEU 54  52  52  LEU LEU B . n 
B 1 55  THR 55  53  53  THR THR B . n 
B 1 56  ASN 56  54  54  ASN ASN B . n 
B 1 57  CYS 57  55  55  CYS CYS B . n 
B 1 58  ALA 58  56  56  ALA ALA B . n 
B 1 59  GLU 59  57  57  GLU GLU B . n 
B 1 60  ARG 60  58  58  ARG ARG B . n 
B 1 61  THR 61  59  59  THR THR B . n 
B 1 62  ALA 62  60  60  ALA ALA B . n 
B 1 63  PHE 63  61  61  PHE PHE B . n 
B 1 64  PHE 64  62  62  PHE PHE B . n 
B 1 65  LYS 65  63  63  LYS LYS B . n 
B 1 66  ALA 66  64  64  ALA ALA B . n 
B 1 67  VAL 67  65  65  VAL VAL B . n 
B 1 68  SER 68  66  66  SER SER B . n 
B 1 69  GLU 69  67  67  GLU GLU B . n 
B 1 70  GLY 70  68  68  GLY GLY B . n 
B 1 71  GLU 71  69  69  GLU GLU B . n 
B 1 72  ARG 72  70  70  ARG ARG B . n 
B 1 73  SER 73  71  71  SER SER B . n 
B 1 74  PHE 74  72  72  PHE PHE B . n 
B 1 75  THR 75  73  73  THR THR B . n 
B 1 76  HIS 76  74  74  HIS HIS B . n 
B 1 77  LEU 77  75  75  LEU LEU B . n 
B 1 78  VAL 78  76  76  VAL VAL B . n 
B 1 79  VAL 79  77  77  VAL VAL B . n 
B 1 80  ALA 80  78  78  ALA ALA B . n 
B 1 81  GLY 81  79  79  GLY GLY B . n 
B 1 82  HIS 82  80  80  HIS HIS B . n 
B 1 83  THR 83  81  81  THR THR B . n 
B 1 84  PRO 84  82  82  PRO PRO B . n 
B 1 85  ASP 85  83  83  ASP ASP B . n 
B 1 86  PRO 86  84  84  PRO PRO B . n 
B 1 87  ILE 87  85  85  ILE ILE B . n 
B 1 88  SER 88  86  86  SER SER B . n 
B 1 89  PRO 89  87  87  PRO PRO B . n 
B 1 90  CYS 90  88  88  CYS CYS B . n 
B 1 91  GLY 91  89  89  GLY GLY B . n 
B 1 92  ALA 92  90  90  ALA ALA B . n 
B 1 93  CYS 93  91  91  CYS CYS B . n 
B 1 94  ARG 94  92  92  ARG ARG B . n 
B 1 95  GLN 95  93  93  GLN GLN B . n 
B 1 96  VAL 96  94  94  VAL VAL B . n 
B 1 97  MET 97  95  95  MET MET B . n 
B 1 98  ALA 98  96  96  ALA ALA B . n 
B 1 99  GLU 99  97  97  GLU GLU B . n 
B 1 100 PHE 100 98  98  PHE PHE B . n 
B 1 101 CYS 101 99  99  CYS CYS B . n 
B 1 102 ALA 102 100 100 ALA ALA B . n 
B 1 103 PRO 103 101 101 PRO PRO B . n 
B 1 104 ASP 104 102 102 ASP ASP B . n 
B 1 105 MET 105 103 103 MET MET B . n 
B 1 106 PRO 106 104 104 PRO PRO B . n 
B 1 107 VAL 107 105 105 VAL VAL B . n 
B 1 108 THR 108 106 106 THR THR B . n 
B 1 109 LEU 109 107 107 LEU LEU B . n 
B 1 110 VAL 110 108 108 VAL VAL B . n 
B 1 111 GLY 111 109 109 GLY GLY B . n 
B 1 112 ASP 112 110 110 ASP ASP B . n 
B 1 113 ASN 113 111 111 ASN ASN B . n 
B 1 114 GLY 114 112 112 GLY GLY B . n 
B 1 115 VAL 115 113 113 VAL VAL B . n 
B 1 116 THR 116 114 114 THR THR B . n 
B 1 117 LYS 117 115 115 LYS LYS B . n 
B 1 118 ALA 118 116 116 ALA ALA B . n 
B 1 119 THR 119 117 117 THR THR B . n 
B 1 120 THR 120 118 118 THR THR B . n 
B 1 121 VAL 121 119 119 VAL VAL B . n 
B 1 122 ARG 122 120 120 ARG ARG B . n 
B 1 123 GLU 123 121 121 GLU GLU B . n 
B 1 124 LEU 124 122 122 LEU LEU B . n 
B 1 125 LEU 125 123 123 LEU LEU B . n 
B 1 126 PRO 126 124 124 PRO PRO B . n 
B 1 127 TYR 127 125 125 TYR TYR B . n 
B 1 128 ALA 128 126 126 ALA ALA B . n 
B 1 129 PHE 129 127 127 PHE PHE B . n 
B 1 130 THR 130 128 128 THR THR B . n 
B 1 131 GLU 131 129 129 GLU GLU B . n 
B 1 132 LYS 132 130 130 LYS LYS B . n 
B 1 133 ASP 133 131 131 ASP ASP B . n 
B 1 134 LEU 134 132 132 LEU LEU B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        Y7U 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   Y7U 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 ZN  1   201 1   ZN  ZN  A . 
D 3 Y7U 1   202 1   Y7U GEA A . 
E 2 ZN  1   201 2   ZN  ZN  B . 
F 3 Y7U 1   202 2   Y7U GEA B . 
G 4 HOH 1   301 154 HOH HOH A . 
G 4 HOH 2   302 31  HOH HOH A . 
G 4 HOH 3   303 214 HOH HOH A . 
G 4 HOH 4   304 284 HOH HOH A . 
G 4 HOH 5   305 285 HOH HOH A . 
G 4 HOH 6   306 26  HOH HOH A . 
G 4 HOH 7   307 70  HOH HOH A . 
G 4 HOH 8   308 71  HOH HOH A . 
G 4 HOH 9   309 50  HOH HOH A . 
G 4 HOH 10  310 192 HOH HOH A . 
G 4 HOH 11  311 196 HOH HOH A . 
G 4 HOH 12  312 10  HOH HOH A . 
G 4 HOH 13  313 266 HOH HOH A . 
G 4 HOH 14  314 131 HOH HOH A . 
G 4 HOH 15  315 126 HOH HOH A . 
G 4 HOH 16  316 240 HOH HOH A . 
G 4 HOH 17  317 103 HOH HOH A . 
G 4 HOH 18  318 264 HOH HOH A . 
G 4 HOH 19  319 7   HOH HOH A . 
G 4 HOH 20  320 194 HOH HOH A . 
G 4 HOH 21  321 64  HOH HOH A . 
G 4 HOH 22  322 156 HOH HOH A . 
G 4 HOH 23  323 41  HOH HOH A . 
G 4 HOH 24  324 292 HOH HOH A . 
G 4 HOH 25  325 15  HOH HOH A . 
G 4 HOH 26  326 102 HOH HOH A . 
G 4 HOH 27  327 22  HOH HOH A . 
G 4 HOH 28  328 96  HOH HOH A . 
G 4 HOH 29  329 206 HOH HOH A . 
G 4 HOH 30  330 77  HOH HOH A . 
G 4 HOH 31  331 168 HOH HOH A . 
G 4 HOH 32  332 33  HOH HOH A . 
G 4 HOH 33  333 129 HOH HOH A . 
G 4 HOH 34  334 99  HOH HOH A . 
G 4 HOH 35  335 91  HOH HOH A . 
G 4 HOH 36  336 322 HOH HOH A . 
G 4 HOH 37  337 106 HOH HOH A . 
G 4 HOH 38  338 142 HOH HOH A . 
G 4 HOH 39  339 178 HOH HOH A . 
G 4 HOH 40  340 25  HOH HOH A . 
G 4 HOH 41  341 24  HOH HOH A . 
G 4 HOH 42  342 107 HOH HOH A . 
G 4 HOH 43  343 248 HOH HOH A . 
G 4 HOH 44  344 115 HOH HOH A . 
G 4 HOH 45  345 13  HOH HOH A . 
G 4 HOH 46  346 81  HOH HOH A . 
G 4 HOH 47  347 57  HOH HOH A . 
G 4 HOH 48  348 47  HOH HOH A . 
G 4 HOH 49  349 120 HOH HOH A . 
G 4 HOH 50  350 145 HOH HOH A . 
G 4 HOH 51  351 220 HOH HOH A . 
G 4 HOH 52  352 4   HOH HOH A . 
G 4 HOH 53  353 203 HOH HOH A . 
G 4 HOH 54  354 39  HOH HOH A . 
G 4 HOH 55  355 32  HOH HOH A . 
G 4 HOH 56  356 249 HOH HOH A . 
G 4 HOH 57  357 187 HOH HOH A . 
G 4 HOH 58  358 290 HOH HOH A . 
G 4 HOH 59  359 3   HOH HOH A . 
G 4 HOH 60  360 89  HOH HOH A . 
G 4 HOH 61  361 153 HOH HOH A . 
G 4 HOH 62  362 173 HOH HOH A . 
G 4 HOH 63  363 23  HOH HOH A . 
G 4 HOH 64  364 113 HOH HOH A . 
G 4 HOH 65  365 87  HOH HOH A . 
G 4 HOH 66  366 114 HOH HOH A . 
G 4 HOH 67  367 75  HOH HOH A . 
G 4 HOH 68  368 85  HOH HOH A . 
G 4 HOH 69  369 235 HOH HOH A . 
G 4 HOH 70  370 20  HOH HOH A . 
G 4 HOH 71  371 122 HOH HOH A . 
G 4 HOH 72  372 177 HOH HOH A . 
G 4 HOH 73  373 291 HOH HOH A . 
G 4 HOH 74  374 148 HOH HOH A . 
G 4 HOH 75  375 19  HOH HOH A . 
G 4 HOH 76  376 137 HOH HOH A . 
G 4 HOH 77  377 242 HOH HOH A . 
G 4 HOH 78  378 72  HOH HOH A . 
G 4 HOH 79  379 69  HOH HOH A . 
G 4 HOH 80  380 254 HOH HOH A . 
G 4 HOH 81  381 287 HOH HOH A . 
G 4 HOH 82  382 158 HOH HOH A . 
G 4 HOH 83  383 6   HOH HOH A . 
G 4 HOH 84  384 9   HOH HOH A . 
G 4 HOH 85  385 21  HOH HOH A . 
G 4 HOH 86  386 45  HOH HOH A . 
G 4 HOH 87  387 219 HOH HOH A . 
G 4 HOH 88  388 65  HOH HOH A . 
G 4 HOH 89  389 252 HOH HOH A . 
G 4 HOH 90  390 174 HOH HOH A . 
G 4 HOH 91  391 62  HOH HOH A . 
G 4 HOH 92  392 190 HOH HOH A . 
G 4 HOH 93  393 11  HOH HOH A . 
G 4 HOH 94  394 104 HOH HOH A . 
G 4 HOH 95  395 226 HOH HOH A . 
G 4 HOH 96  396 27  HOH HOH A . 
G 4 HOH 97  397 90  HOH HOH A . 
G 4 HOH 98  398 217 HOH HOH A . 
G 4 HOH 99  399 257 HOH HOH A . 
G 4 HOH 100 400 211 HOH HOH A . 
G 4 HOH 101 401 8   HOH HOH A . 
G 4 HOH 102 402 78  HOH HOH A . 
G 4 HOH 103 403 228 HOH HOH A . 
G 4 HOH 104 404 181 HOH HOH A . 
G 4 HOH 105 405 110 HOH HOH A . 
G 4 HOH 106 406 227 HOH HOH A . 
G 4 HOH 107 407 66  HOH HOH A . 
G 4 HOH 108 408 186 HOH HOH A . 
G 4 HOH 109 409 144 HOH HOH A . 
G 4 HOH 110 410 40  HOH HOH A . 
G 4 HOH 111 411 231 HOH HOH A . 
G 4 HOH 112 412 30  HOH HOH A . 
G 4 HOH 113 413 216 HOH HOH A . 
G 4 HOH 114 414 73  HOH HOH A . 
G 4 HOH 115 415 319 HOH HOH A . 
G 4 HOH 116 416 143 HOH HOH A . 
G 4 HOH 117 417 295 HOH HOH A . 
G 4 HOH 118 418 296 HOH HOH A . 
G 4 HOH 119 419 55  HOH HOH A . 
G 4 HOH 120 420 251 HOH HOH A . 
G 4 HOH 121 421 261 HOH HOH A . 
G 4 HOH 122 422 201 HOH HOH A . 
G 4 HOH 123 423 281 HOH HOH A . 
G 4 HOH 124 424 260 HOH HOH A . 
G 4 HOH 125 425 134 HOH HOH A . 
G 4 HOH 126 426 316 HOH HOH A . 
G 4 HOH 127 427 244 HOH HOH A . 
G 4 HOH 128 428 202 HOH HOH A . 
G 4 HOH 129 429 263 HOH HOH A . 
G 4 HOH 130 430 193 HOH HOH A . 
G 4 HOH 131 431 150 HOH HOH A . 
G 4 HOH 132 432 210 HOH HOH A . 
G 4 HOH 133 433 314 HOH HOH A . 
G 4 HOH 134 434 278 HOH HOH A . 
G 4 HOH 135 435 184 HOH HOH A . 
G 4 HOH 136 436 241 HOH HOH A . 
G 4 HOH 137 437 49  HOH HOH A . 
G 4 HOH 138 438 267 HOH HOH A . 
G 4 HOH 139 439 279 HOH HOH A . 
G 4 HOH 140 440 175 HOH HOH A . 
G 4 HOH 141 441 182 HOH HOH A . 
G 4 HOH 142 442 46  HOH HOH A . 
G 4 HOH 143 443 258 HOH HOH A . 
G 4 HOH 144 444 229 HOH HOH A . 
G 4 HOH 145 445 51  HOH HOH A . 
G 4 HOH 146 446 320 HOH HOH A . 
G 4 HOH 147 447 119 HOH HOH A . 
G 4 HOH 148 448 247 HOH HOH A . 
G 4 HOH 149 449 302 HOH HOH A . 
G 4 HOH 150 450 123 HOH HOH A . 
G 4 HOH 151 451 160 HOH HOH A . 
G 4 HOH 152 452 149 HOH HOH A . 
G 4 HOH 153 453 139 HOH HOH A . 
G 4 HOH 154 454 301 HOH HOH A . 
G 4 HOH 155 455 275 HOH HOH A . 
G 4 HOH 156 456 289 HOH HOH A . 
G 4 HOH 157 457 100 HOH HOH A . 
G 4 HOH 158 458 213 HOH HOH A . 
G 4 HOH 159 459 188 HOH HOH A . 
G 4 HOH 160 460 135 HOH HOH A . 
G 4 HOH 161 461 262 HOH HOH A . 
G 4 HOH 162 462 180 HOH HOH A . 
G 4 HOH 163 463 198 HOH HOH A . 
G 4 HOH 164 464 234 HOH HOH A . 
G 4 HOH 165 465 118 HOH HOH A . 
G 4 HOH 166 466 105 HOH HOH A . 
G 4 HOH 167 467 300 HOH HOH A . 
G 4 HOH 168 468 59  HOH HOH A . 
G 4 HOH 169 469 282 HOH HOH A . 
G 4 HOH 170 470 315 HOH HOH A . 
G 4 HOH 171 471 162 HOH HOH A . 
G 4 HOH 172 472 166 HOH HOH A . 
G 4 HOH 173 473 171 HOH HOH A . 
G 4 HOH 174 474 232 HOH HOH A . 
G 4 HOH 175 475 68  HOH HOH A . 
G 4 HOH 176 476 239 HOH HOH A . 
G 4 HOH 177 477 221 HOH HOH A . 
G 4 HOH 178 478 268 HOH HOH A . 
H 4 HOH 1   301 265 HOH HOH B . 
H 4 HOH 2   302 308 HOH HOH B . 
H 4 HOH 3   303 74  HOH HOH B . 
H 4 HOH 4   304 108 HOH HOH B . 
H 4 HOH 5   305 305 HOH HOH B . 
H 4 HOH 6   306 164 HOH HOH B . 
H 4 HOH 7   307 38  HOH HOH B . 
H 4 HOH 8   308 293 HOH HOH B . 
H 4 HOH 9   309 133 HOH HOH B . 
H 4 HOH 10  310 199 HOH HOH B . 
H 4 HOH 11  311 80  HOH HOH B . 
H 4 HOH 12  312 42  HOH HOH B . 
H 4 HOH 13  313 95  HOH HOH B . 
H 4 HOH 14  314 124 HOH HOH B . 
H 4 HOH 15  315 52  HOH HOH B . 
H 4 HOH 16  316 288 HOH HOH B . 
H 4 HOH 17  317 313 HOH HOH B . 
H 4 HOH 18  318 109 HOH HOH B . 
H 4 HOH 19  319 170 HOH HOH B . 
H 4 HOH 20  320 18  HOH HOH B . 
H 4 HOH 21  321 147 HOH HOH B . 
H 4 HOH 22  322 243 HOH HOH B . 
H 4 HOH 23  323 218 HOH HOH B . 
H 4 HOH 24  324 36  HOH HOH B . 
H 4 HOH 25  325 233 HOH HOH B . 
H 4 HOH 26  326 125 HOH HOH B . 
H 4 HOH 27  327 56  HOH HOH B . 
H 4 HOH 28  328 1   HOH HOH B . 
H 4 HOH 29  329 205 HOH HOH B . 
H 4 HOH 30  330 37  HOH HOH B . 
H 4 HOH 31  331 128 HOH HOH B . 
H 4 HOH 32  332 43  HOH HOH B . 
H 4 HOH 33  333 60  HOH HOH B . 
H 4 HOH 34  334 88  HOH HOH B . 
H 4 HOH 35  335 253 HOH HOH B . 
H 4 HOH 36  336 54  HOH HOH B . 
H 4 HOH 37  337 212 HOH HOH B . 
H 4 HOH 38  338 97  HOH HOH B . 
H 4 HOH 39  339 183 HOH HOH B . 
H 4 HOH 40  340 117 HOH HOH B . 
H 4 HOH 41  341 92  HOH HOH B . 
H 4 HOH 42  342 138 HOH HOH B . 
H 4 HOH 43  343 76  HOH HOH B . 
H 4 HOH 44  344 167 HOH HOH B . 
H 4 HOH 45  345 84  HOH HOH B . 
H 4 HOH 46  346 286 HOH HOH B . 
H 4 HOH 47  347 86  HOH HOH B . 
H 4 HOH 48  348 5   HOH HOH B . 
H 4 HOH 49  349 223 HOH HOH B . 
H 4 HOH 50  350 276 HOH HOH B . 
H 4 HOH 51  351 136 HOH HOH B . 
H 4 HOH 52  352 140 HOH HOH B . 
H 4 HOH 53  353 35  HOH HOH B . 
H 4 HOH 54  354 207 HOH HOH B . 
H 4 HOH 55  355 48  HOH HOH B . 
H 4 HOH 56  356 151 HOH HOH B . 
H 4 HOH 57  357 224 HOH HOH B . 
H 4 HOH 58  358 53  HOH HOH B . 
H 4 HOH 59  359 255 HOH HOH B . 
H 4 HOH 60  360 67  HOH HOH B . 
H 4 HOH 61  361 82  HOH HOH B . 
H 4 HOH 62  362 29  HOH HOH B . 
H 4 HOH 63  363 61  HOH HOH B . 
H 4 HOH 64  364 94  HOH HOH B . 
H 4 HOH 65  365 250 HOH HOH B . 
H 4 HOH 66  366 238 HOH HOH B . 
H 4 HOH 67  367 236 HOH HOH B . 
H 4 HOH 68  368 28  HOH HOH B . 
H 4 HOH 69  369 225 HOH HOH B . 
H 4 HOH 70  370 163 HOH HOH B . 
H 4 HOH 71  371 2   HOH HOH B . 
H 4 HOH 72  372 14  HOH HOH B . 
H 4 HOH 73  373 17  HOH HOH B . 
H 4 HOH 74  374 16  HOH HOH B . 
H 4 HOH 75  375 222 HOH HOH B . 
H 4 HOH 76  376 200 HOH HOH B . 
H 4 HOH 77  377 44  HOH HOH B . 
H 4 HOH 78  378 58  HOH HOH B . 
H 4 HOH 79  379 274 HOH HOH B . 
H 4 HOH 80  380 34  HOH HOH B . 
H 4 HOH 81  381 83  HOH HOH B . 
H 4 HOH 82  382 185 HOH HOH B . 
H 4 HOH 83  383 93  HOH HOH B . 
H 4 HOH 84  384 245 HOH HOH B . 
H 4 HOH 85  385 155 HOH HOH B . 
H 4 HOH 86  386 101 HOH HOH B . 
H 4 HOH 87  387 141 HOH HOH B . 
H 4 HOH 88  388 271 HOH HOH B . 
H 4 HOH 89  389 189 HOH HOH B . 
H 4 HOH 90  390 127 HOH HOH B . 
H 4 HOH 91  391 116 HOH HOH B . 
H 4 HOH 92  392 311 HOH HOH B . 
H 4 HOH 93  393 79  HOH HOH B . 
H 4 HOH 94  394 169 HOH HOH B . 
H 4 HOH 95  395 121 HOH HOH B . 
H 4 HOH 96  396 270 HOH HOH B . 
H 4 HOH 97  397 303 HOH HOH B . 
H 4 HOH 98  398 306 HOH HOH B . 
H 4 HOH 99  399 246 HOH HOH B . 
H 4 HOH 100 400 209 HOH HOH B . 
H 4 HOH 101 401 304 HOH HOH B . 
H 4 HOH 102 402 204 HOH HOH B . 
H 4 HOH 103 403 312 HOH HOH B . 
H 4 HOH 104 404 152 HOH HOH B . 
H 4 HOH 105 405 195 HOH HOH B . 
H 4 HOH 106 406 283 HOH HOH B . 
H 4 HOH 107 407 310 HOH HOH B . 
H 4 HOH 108 408 63  HOH HOH B . 
H 4 HOH 109 409 259 HOH HOH B . 
H 4 HOH 110 410 323 HOH HOH B . 
H 4 HOH 111 411 321 HOH HOH B . 
H 4 HOH 112 412 277 HOH HOH B . 
H 4 HOH 113 413 165 HOH HOH B . 
H 4 HOH 114 414 294 HOH HOH B . 
H 4 HOH 115 415 269 HOH HOH B . 
H 4 HOH 116 416 280 HOH HOH B . 
H 4 HOH 117 417 146 HOH HOH B . 
H 4 HOH 118 418 157 HOH HOH B . 
H 4 HOH 119 419 317 HOH HOH B . 
H 4 HOH 120 420 132 HOH HOH B . 
H 4 HOH 121 421 309 HOH HOH B . 
H 4 HOH 122 422 111 HOH HOH B . 
H 4 HOH 123 423 307 HOH HOH B . 
H 4 HOH 124 424 272 HOH HOH B . 
H 4 HOH 125 425 112 HOH HOH B . 
H 4 HOH 126 426 176 HOH HOH B . 
H 4 HOH 127 427 197 HOH HOH B . 
H 4 HOH 128 428 172 HOH HOH B . 
H 4 HOH 129 429 237 HOH HOH B . 
H 4 HOH 130 430 191 HOH HOH B . 
H 4 HOH 131 431 297 HOH HOH B . 
H 4 HOH 132 432 161 HOH HOH B . 
H 4 HOH 133 433 230 HOH HOH B . 
H 4 HOH 134 434 318 HOH HOH B . 
H 4 HOH 135 435 215 HOH HOH B . 
H 4 HOH 136 436 130 HOH HOH B . 
H 4 HOH 137 437 12  HOH HOH B . 
H 4 HOH 138 438 98  HOH HOH B . 
H 4 HOH 139 439 159 HOH HOH B . 
H 4 HOH 140 440 273 HOH HOH B . 
H 4 HOH 141 441 208 HOH HOH B . 
H 4 HOH 142 442 299 HOH HOH B . 
H 4 HOH 143 443 298 HOH HOH B . 
H 4 HOH 144 444 179 HOH HOH B . 
H 4 HOH 145 445 256 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? .           1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? SHELXS   ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8X6U 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     82.914 
_cell.length_a_esd                 ? 
_cell.length_b                     82.914 
_cell.length_b_esd                 ? 
_cell.length_c                     81.646 
_cell.length_c_esd                 ? 
_cell.volume                       486095.140 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8X6U 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            
;P 32 2"
;
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8X6U 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.80 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.01 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Tris, pH 8.5, 2.2 M ammonium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            290 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-08-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.987 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL18U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.987 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL18U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          19.92 
_reflns.entry_id                                       8X6U 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.75 
_reflns.d_resolution_low                               30 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     33271 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                18.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          48.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.126 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.75 
_reflns_shell.d_res_low                                     1.78 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1637 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.439 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.30 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8X6U 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.75 
_refine.ls_d_res_low                             29.09 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     33271 
_refine.ls_number_reflns_R_free                  2001 
_refine.ls_number_reflns_R_work                  31270 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.84 
_refine.ls_percent_reflns_R_free                 6.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1627 
_refine.ls_R_factor_R_free                       0.1857 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1612 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.38 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      AlphaFold 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 17.9009 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1335 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.75 
_refine_hist.d_res_low                        29.09 
_refine_hist.number_atoms_solvent             323 
_refine_hist.number_atoms_total               2369 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2008 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         38 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0073 ? 2092 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9786 ? 2856 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0587 ? 328  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0087 ? 368  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 8.1082 ? 306  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.75 1.79  . . 141 2170 97.92  . . . . 0.1922 . . . . . . . . . . . 0.2345 
'X-RAY DIFFRACTION' 1.79 1.84  . . 139 2197 100.00 . . . . 0.1744 . . . . . . . . . . . 0.2324 
'X-RAY DIFFRACTION' 1.84 1.89  . . 137 2195 100.00 . . . . 0.1843 . . . . . . . . . . . 0.2170 
'X-RAY DIFFRACTION' 1.89 1.95  . . 141 2219 100.00 . . . . 0.1785 . . . . . . . . . . . 0.2092 
'X-RAY DIFFRACTION' 1.95 2.02  . . 142 2216 100.00 . . . . 0.1794 . . . . . . . . . . . 0.2215 
'X-RAY DIFFRACTION' 2.02 2.11  . . 144 2223 100.00 . . . . 0.1630 . . . . . . . . . . . 0.1888 
'X-RAY DIFFRACTION' 2.11 2.20  . . 140 2226 100.00 . . . . 0.1757 . . . . . . . . . . . 0.1725 
'X-RAY DIFFRACTION' 2.20 2.32  . . 143 2232 100.00 . . . . 0.1700 . . . . . . . . . . . 0.1938 
'X-RAY DIFFRACTION' 2.32 2.46  . . 142 2205 100.00 . . . . 0.1741 . . . . . . . . . . . 0.1814 
'X-RAY DIFFRACTION' 2.46 2.65  . . 140 2251 100.00 . . . . 0.1639 . . . . . . . . . . . 0.2148 
'X-RAY DIFFRACTION' 2.65 2.92  . . 146 2228 100.00 . . . . 0.1708 . . . . . . . . . . . 0.2093 
'X-RAY DIFFRACTION' 2.92 3.34  . . 148 2256 100.00 . . . . 0.1652 . . . . . . . . . . . 0.1926 
'X-RAY DIFFRACTION' 3.34 4.20  . . 145 2278 100.00 . . . . 0.1391 . . . . . . . . . . . 0.1252 
'X-RAY DIFFRACTION' 4.21 29.09 . . 153 2374 99.80  . . . . 0.1435 . . . . . . . . . . . 0.1860 
# 
_struct.entry_id                     8X6U 
_struct.title                        'Crystal structure of EfCDA in complex with dFdU' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8X6U 
_struct_keywords.text            'cytidine deaminase, gemcitabine, dFdU, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8X6U 
_struct_ref.pdbx_db_accession          8X6U 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8X6U A 1 ? 134 ? 8X6U -1 ? 132 ? -1 132 
2 1 8X6U B 1 ? 134 ? 8X6U -1 ? 132 ? -1 132 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 10620 ? 
1 MORE         -84   ? 
1 'SSA (A^2)'  19060 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   homology 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z          1.0000000000  0.0000000000  0.0000000000 0.0000000000 0.0000000000  
1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 6_554 -x,-x+y,-z-1/3 -0.5000000000 -0.8660254038 0.0000000000 0.0000000000 -0.8660254038 
0.5000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 -27.2153333333 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 2   ? LEU A 18  ? SER A 0   LEU A 16  1 ? 17 
HELX_P HELX_P2  AA2 ASP A 19  ? ALA A 21  ? ASP A 17  ALA A 19  5 ? 3  
HELX_P HELX_P3  AA3 SER A 51  ? THR A 55  ? SER A 49  THR A 53  5 ? 5  
HELX_P HELX_P4  AA4 CYS A 57  ? GLU A 69  ? CYS A 55  GLU A 67  1 ? 13 
HELX_P HELX_P5  AA5 CYS A 90  ? CYS A 101 ? CYS A 88  CYS A 99  1 ? 12 
HELX_P HELX_P6  AA6 ASP A 112 ? GLY A 114 ? ASP A 110 GLY A 112 5 ? 3  
HELX_P HELX_P7  AA7 VAL A 121 ? LEU A 125 ? VAL A 119 LEU A 123 1 ? 5  
HELX_P HELX_P8  AA8 THR A 130 ? LEU A 134 ? THR A 128 LEU A 132 5 ? 5  
HELX_P HELX_P9  AA9 LYS B 7   ? ALA B 17  ? LYS B 5   ALA B 15  1 ? 11 
HELX_P HELX_P10 AB1 LEU B 18  ? ALA B 21  ? LEU B 16  ALA B 19  5 ? 4  
HELX_P HELX_P11 AB2 SER B 51  ? THR B 55  ? SER B 49  THR B 53  5 ? 5  
HELX_P HELX_P12 AB3 CYS B 57  ? GLU B 69  ? CYS B 55  GLU B 67  1 ? 13 
HELX_P HELX_P13 AB4 CYS B 90  ? CYS B 101 ? CYS B 88  CYS B 99  1 ? 12 
HELX_P HELX_P14 AB5 ASP B 112 ? GLY B 114 ? ASP B 110 GLY B 112 5 ? 3  
HELX_P HELX_P15 AB6 VAL B 121 ? LEU B 125 ? VAL B 119 LEU B 123 1 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A CYS 57 SG ? ? ? 1_555 C ZN  . ZN ? ? A CYS 55  A ZN  201 1_555 ? ? ? ? ? ? ? 2.313 ? ? 
metalc2 metalc ? ? A CYS 90 SG ? ? ? 1_555 C ZN  . ZN ? ? A CYS 88  A ZN  201 1_555 ? ? ? ? ? ? ? 2.304 ? ? 
metalc3 metalc ? ? A CYS 93 SG ? ? ? 1_555 C ZN  . ZN ? ? A CYS 91  A ZN  201 1_555 ? ? ? ? ? ? ? 2.281 ? ? 
metalc4 metalc ? ? C ZN  .  ZN ? ? ? 1_555 D Y7U . O5 ? ? A ZN  201 A Y7U 202 1_555 ? ? ? ? ? ? ? 2.356 ? ? 
metalc5 metalc ? ? B CYS 57 SG ? ? ? 1_555 E ZN  . ZN ? ? B CYS 55  B ZN  201 1_555 ? ? ? ? ? ? ? 2.314 ? ? 
metalc6 metalc ? ? B CYS 90 SG ? ? ? 1_555 E ZN  . ZN ? ? B CYS 88  B ZN  201 1_555 ? ? ? ? ? ? ? 2.319 ? ? 
metalc7 metalc ? ? B CYS 93 SG ? ? ? 1_555 E ZN  . ZN ? ? B CYS 91  B ZN  201 1_555 ? ? ? ? ? ? ? 2.273 ? ? 
metalc8 metalc ? ? E ZN  .  ZN ? ? ? 1_555 F Y7U . O5 ? ? B ZN  201 B Y7U 202 1_555 ? ? ? ? ? ? ? 2.411 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG ? A CYS 57 ? A CYS 55 ? 1_555 ZN ? C ZN . ? A ZN 201 ? 1_555 SG ? A CYS 90 ? A CYS 88  ? 1_555 113.3 ? 
2  SG ? A CYS 57 ? A CYS 55 ? 1_555 ZN ? C ZN . ? A ZN 201 ? 1_555 SG ? A CYS 93 ? A CYS 91  ? 1_555 102.7 ? 
3  SG ? A CYS 90 ? A CYS 88 ? 1_555 ZN ? C ZN . ? A ZN 201 ? 1_555 SG ? A CYS 93 ? A CYS 91  ? 1_555 122.2 ? 
4  SG ? A CYS 57 ? A CYS 55 ? 1_555 ZN ? C ZN . ? A ZN 201 ? 1_555 O5 ? D Y7U .  ? A Y7U 202 ? 1_555 112.1 ? 
5  SG ? A CYS 90 ? A CYS 88 ? 1_555 ZN ? C ZN . ? A ZN 201 ? 1_555 O5 ? D Y7U .  ? A Y7U 202 ? 1_555 100.8 ? 
6  SG ? A CYS 93 ? A CYS 91 ? 1_555 ZN ? C ZN . ? A ZN 201 ? 1_555 O5 ? D Y7U .  ? A Y7U 202 ? 1_555 105.7 ? 
7  SG ? B CYS 57 ? B CYS 55 ? 1_555 ZN ? E ZN . ? B ZN 201 ? 1_555 SG ? B CYS 90 ? B CYS 88  ? 1_555 113.8 ? 
8  SG ? B CYS 57 ? B CYS 55 ? 1_555 ZN ? E ZN . ? B ZN 201 ? 1_555 SG ? B CYS 93 ? B CYS 91  ? 1_555 102.4 ? 
9  SG ? B CYS 90 ? B CYS 88 ? 1_555 ZN ? E ZN . ? B ZN 201 ? 1_555 SG ? B CYS 93 ? B CYS 91  ? 1_555 123.1 ? 
10 SG ? B CYS 57 ? B CYS 55 ? 1_555 ZN ? E ZN . ? B ZN 201 ? 1_555 O5 ? F Y7U .  ? B Y7U 202 ? 1_555 108.2 ? 
11 SG ? B CYS 90 ? B CYS 88 ? 1_555 ZN ? E ZN . ? B ZN 201 ? 1_555 O5 ? F Y7U .  ? B Y7U 202 ? 1_555 101.2 ? 
12 SG ? B CYS 93 ? B CYS 91 ? 1_555 ZN ? E ZN . ? B ZN 201 ? 1_555 O5 ? F Y7U .  ? B Y7U 202 ? 1_555 107.4 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? parallel      
AA2 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 41  ? ILE A 45  ? ILE A 39  ILE A 43  
AA1 2 VAL A 30  ? THR A 36  ? VAL A 28  THR A 34  
AA1 3 PHE A 74  ? GLY A 81  ? PHE A 72  GLY A 79  
AA1 4 PRO A 106 ? VAL A 110 ? PRO A 104 VAL A 108 
AA1 5 THR A 116 ? THR A 120 ? THR A 114 THR A 118 
AA2 1 ILE B 41  ? ILE B 45  ? ILE B 39  ILE B 43  
AA2 2 VAL B 30  ? THR B 36  ? VAL B 28  THR B 34  
AA2 3 PHE B 74  ? GLY B 81  ? PHE B 72  GLY B 79  
AA2 4 PRO B 106 ? VAL B 110 ? PRO B 104 VAL B 108 
AA2 5 THR B 116 ? THR B 120 ? THR B 114 THR B 118 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O TYR A 42  ? O TYR A 40  N LEU A 34  ? N LEU A 32  
AA1 2 3 N VAL A 35  ? N VAL A 33  O HIS A 76  ? O HIS A 74  
AA1 3 4 N LEU A 77  ? N LEU A 75  O THR A 108 ? O THR A 106 
AA1 4 5 N LEU A 109 ? N LEU A 107 O LYS A 117 ? O LYS A 115 
AA2 1 2 O TYR B 42  ? O TYR B 40  N LEU B 34  ? N LEU B 32  
AA2 2 3 N VAL B 35  ? N VAL B 33  O HIS B 76  ? O HIS B 74  
AA2 3 4 N VAL B 79  ? N VAL B 77  O VAL B 110 ? O VAL B 108 
AA2 4 5 N VAL B 107 ? N VAL B 105 O THR B 119 ? O THR B 117 
# 
_pdbx_entry_details.entry_id                   8X6U 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   B HOH 305 ? ? O B HOH 398 ? ? 1.74 
2 1 O   A HOH 324 ? ? O A HOH 439 ? ? 1.91 
3 1 NH1 B ARG 120 ? ? O B HOH 301 ? ? 1.98 
4 1 O   A HOH 419 ? ? O A HOH 460 ? ? 2.06 
5 1 O   A HOH 452 ? ? O A HOH 462 ? ? 2.10 
6 1 O   A HOH 422 ? ? O A HOH 428 ? ? 2.11 
7 1 OE1 A GLU 3   ? ? O A HOH 301 ? ? 2.19 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 377 ? ? 1_555 O A HOH 448 ? ? 6_554 2.11 
2 1 O A HOH 427 ? ? 1_555 O A HOH 448 ? ? 6_554 2.19 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 445 ? G HOH . 
2 1 B HOH 414 ? H HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+2/3   
3 -x+y,-x,z+1/3  
4 x-y,-y,-z+1/3  
5 -x,-x+y,-z+2/3 
6 y,x,-z         
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       478 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.12 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY -1 ? A GLY 1 
2 1 Y 1 B GLY -1 ? B GLY 1 
3 1 Y 1 B SER 0  ? B SER 2 
4 1 Y 1 B MET 1  ? B MET 3 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MET N    N  N N 230 
MET CA   C  N S 231 
MET C    C  N N 232 
MET O    O  N N 233 
MET CB   C  N N 234 
MET CG   C  N N 235 
MET SD   S  N N 236 
MET CE   C  N N 237 
MET OXT  O  N N 238 
MET H    H  N N 239 
MET H2   H  N N 240 
MET HA   H  N N 241 
MET HB2  H  N N 242 
MET HB3  H  N N 243 
MET HG2  H  N N 244 
MET HG3  H  N N 245 
MET HE1  H  N N 246 
MET HE2  H  N N 247 
MET HE3  H  N N 248 
MET HXT  H  N N 249 
PHE N    N  N N 250 
PHE CA   C  N S 251 
PHE C    C  N N 252 
PHE O    O  N N 253 
PHE CB   C  N N 254 
PHE CG   C  Y N 255 
PHE CD1  C  Y N 256 
PHE CD2  C  Y N 257 
PHE CE1  C  Y N 258 
PHE CE2  C  Y N 259 
PHE CZ   C  Y N 260 
PHE OXT  O  N N 261 
PHE H    H  N N 262 
PHE H2   H  N N 263 
PHE HA   H  N N 264 
PHE HB2  H  N N 265 
PHE HB3  H  N N 266 
PHE HD1  H  N N 267 
PHE HD2  H  N N 268 
PHE HE1  H  N N 269 
PHE HE2  H  N N 270 
PHE HZ   H  N N 271 
PHE HXT  H  N N 272 
PRO N    N  N N 273 
PRO CA   C  N S 274 
PRO C    C  N N 275 
PRO O    O  N N 276 
PRO CB   C  N N 277 
PRO CG   C  N N 278 
PRO CD   C  N N 279 
PRO OXT  O  N N 280 
PRO H    H  N N 281 
PRO HA   H  N N 282 
PRO HB2  H  N N 283 
PRO HB3  H  N N 284 
PRO HG2  H  N N 285 
PRO HG3  H  N N 286 
PRO HD2  H  N N 287 
PRO HD3  H  N N 288 
PRO HXT  H  N N 289 
SER N    N  N N 290 
SER CA   C  N S 291 
SER C    C  N N 292 
SER O    O  N N 293 
SER CB   C  N N 294 
SER OG   O  N N 295 
SER OXT  O  N N 296 
SER H    H  N N 297 
SER H2   H  N N 298 
SER HA   H  N N 299 
SER HB2  H  N N 300 
SER HB3  H  N N 301 
SER HG   H  N N 302 
SER HXT  H  N N 303 
THR N    N  N N 304 
THR CA   C  N S 305 
THR C    C  N N 306 
THR O    O  N N 307 
THR CB   C  N R 308 
THR OG1  O  N N 309 
THR CG2  C  N N 310 
THR OXT  O  N N 311 
THR H    H  N N 312 
THR H2   H  N N 313 
THR HA   H  N N 314 
THR HB   H  N N 315 
THR HG1  H  N N 316 
THR HG21 H  N N 317 
THR HG22 H  N N 318 
THR HG23 H  N N 319 
THR HXT  H  N N 320 
TRP N    N  N N 321 
TRP CA   C  N S 322 
TRP C    C  N N 323 
TRP O    O  N N 324 
TRP CB   C  N N 325 
TRP CG   C  Y N 326 
TRP CD1  C  Y N 327 
TRP CD2  C  Y N 328 
TRP NE1  N  Y N 329 
TRP CE2  C  Y N 330 
TRP CE3  C  Y N 331 
TRP CZ2  C  Y N 332 
TRP CZ3  C  Y N 333 
TRP CH2  C  Y N 334 
TRP OXT  O  N N 335 
TRP H    H  N N 336 
TRP H2   H  N N 337 
TRP HA   H  N N 338 
TRP HB2  H  N N 339 
TRP HB3  H  N N 340 
TRP HD1  H  N N 341 
TRP HE1  H  N N 342 
TRP HE3  H  N N 343 
TRP HZ2  H  N N 344 
TRP HZ3  H  N N 345 
TRP HH2  H  N N 346 
TRP HXT  H  N N 347 
TYR N    N  N N 348 
TYR CA   C  N S 349 
TYR C    C  N N 350 
TYR O    O  N N 351 
TYR CB   C  N N 352 
TYR CG   C  Y N 353 
TYR CD1  C  Y N 354 
TYR CD2  C  Y N 355 
TYR CE1  C  Y N 356 
TYR CE2  C  Y N 357 
TYR CZ   C  Y N 358 
TYR OH   O  N N 359 
TYR OXT  O  N N 360 
TYR H    H  N N 361 
TYR H2   H  N N 362 
TYR HA   H  N N 363 
TYR HB2  H  N N 364 
TYR HB3  H  N N 365 
TYR HD1  H  N N 366 
TYR HD2  H  N N 367 
TYR HE1  H  N N 368 
TYR HE2  H  N N 369 
TYR HH   H  N N 370 
TYR HXT  H  N N 371 
VAL N    N  N N 372 
VAL CA   C  N S 373 
VAL C    C  N N 374 
VAL O    O  N N 375 
VAL CB   C  N N 376 
VAL CG1  C  N N 377 
VAL CG2  C  N N 378 
VAL OXT  O  N N 379 
VAL H    H  N N 380 
VAL H2   H  N N 381 
VAL HA   H  N N 382 
VAL HB   H  N N 383 
VAL HG11 H  N N 384 
VAL HG12 H  N N 385 
VAL HG13 H  N N 386 
VAL HG21 H  N N 387 
VAL HG22 H  N N 388 
VAL HG23 H  N N 389 
VAL HXT  H  N N 390 
Y7U N1   N  N N 391 
Y7U C2   C  N N 392 
Y7U O3   O  N N 393 
Y7U C4   C  N N 394 
Y7U C5   C  N R 395 
Y7U C6   C  N N 396 
Y7U C7   C  N R 397 
Y7U C9   C  N N 398 
Y7U C1   C  N N 399 
Y7U C3   C  N N 400 
Y7U C8   C  N R 401 
Y7U F1   F  N N 402 
Y7U F2   F  N N 403 
Y7U N2   N  N N 404 
Y7U O1   O  N N 405 
Y7U O2   O  N N 406 
Y7U O4   O  N N 407 
Y7U O5   O  N N 408 
Y7U H2   H  N N 409 
Y7U H10  H  N N 410 
Y7U H5   H  N N 411 
Y7U H6   H  N N 412 
Y7U H9   H  N N 413 
Y7U H8   H  N N 414 
Y7U H1   H  N N 415 
Y7U H7   H  N N 416 
Y7U HN2  H  N N 417 
Y7U H11  H  N N 418 
ZN  ZN   ZN N N 419 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
Y7U C1  C2   doub N N 376 
Y7U C1  C4   sing N N 377 
Y7U C2  N1   sing N N 378 
Y7U N1  C3   sing N N 379 
Y7U N1  C5   sing N N 380 
Y7U C3  O1   doub N N 381 
Y7U C3  N2   sing N N 382 
Y7U N2  C4   sing N N 383 
Y7U C4  O5   doub N N 384 
Y7U C5  C6   sing N N 385 
Y7U C5  O2   sing N N 386 
Y7U C6  C7   sing N N 387 
Y7U C6  F1   sing N N 388 
Y7U C6  F2   sing N N 389 
Y7U C7  C8   sing N N 390 
Y7U C7  O4   sing N N 391 
Y7U C8  O2   sing N N 392 
Y7U C8  C9   sing N N 393 
Y7U C9  O3   sing N N 394 
Y7U C2  H2   sing N N 395 
Y7U O3  H10  sing N N 396 
Y7U C5  H5   sing N N 397 
Y7U C7  H6   sing N N 398 
Y7U C9  H9   sing N N 399 
Y7U C9  H8   sing N N 400 
Y7U C1  H1   sing N N 401 
Y7U C8  H7   sing N N 402 
Y7U N2  HN2  sing N N 403 
Y7U O4  H11  sing N N 404 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Natural Science Foundation of China (NSFC)' China 32171186 1 
'National Natural Science Foundation of China (NSFC)' China 31870741 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 32 2 1' 
_space_group.name_Hall        
;P 32 2"
;
_space_group.IT_number        154 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8X6U 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012061 
_atom_sites.fract_transf_matrix[1][2]   0.006963 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013926 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012248 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428  4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 2   ? 36.59189 -5.18063  -6.54093  1.000 26.95491 ? 0   SER A N   1 
ATOM   2    C  CA  . SER A 1 2   ? 35.13883 -5.06546  -6.66350  1.000 29.48051 ? 0   SER A CA  1 
ATOM   3    C  C   . SER A 1 2   ? 34.52497 -6.40048  -7.06616  1.000 32.54852 ? 0   SER A C   1 
ATOM   4    O  O   . SER A 1 2   ? 35.22014 -7.28695  -7.58644  1.000 30.95623 ? 0   SER A O   1 
ATOM   5    C  CB  . SER A 1 2   ? 34.76870 -3.98954  -7.67579  1.000 32.51549 ? 0   SER A CB  1 
ATOM   6    O  OG  . SER A 1 2   ? 34.92149 -4.47704  -8.99365  1.000 33.77691 ? 0   SER A OG  1 
ATOM   7    N  N   . MET A 1 3   ? 33.21632 -6.52746  -6.83055  1.000 32.05358 ? 1   MET A N   1 
ATOM   8    C  CA  . MET A 1 3   ? 32.52925 -7.77351  -7.14940  1.000 35.44226 ? 1   MET A CA  1 
ATOM   9    C  C   . MET A 1 3   ? 32.57732 -8.04193  -8.65139  1.000 35.38477 ? 1   MET A C   1 
ATOM   10   O  O   . MET A 1 3   ? 32.66344 -9.20159  -9.08097  1.000 33.03368 ? 1   MET A O   1 
ATOM   11   C  CB  . MET A 1 3   ? 31.07474 -7.71175  -6.66870  1.000 34.75461 ? 1   MET A CB  1 
ATOM   12   C  CG  . MET A 1 3   ? 30.87186 -7.78024  -5.13666  1.000 37.75179 ? 1   MET A CG  1 
ATOM   13   S  SD  . MET A 1 3   ? 31.94947 -8.86393  -4.14509  1.000 35.81030 ? 1   MET A SD  1 
ATOM   14   C  CE  . MET A 1 3   ? 31.60364 -10.49613 -4.84260  1.000 33.64663 ? 1   MET A CE  1 
ATOM   15   N  N   . ALA A 1 4   ? 32.53794 -6.97948  -9.46367  1.000 34.36472 ? 2   ALA A N   1 
ATOM   16   C  CA  . ALA A 1 4   ? 32.58061 -7.15005  -10.91389 1.000 33.32654 ? 2   ALA A CA  1 
ATOM   17   C  C   . ALA A 1 4   ? 33.96514 -7.58583  -11.38458 1.000 34.35849 ? 2   ALA A C   1 
ATOM   18   O  O   . ALA A 1 4   ? 34.08315 -8.39607  -12.31582 1.000 33.58115 ? 2   ALA A O   1 
ATOM   19   C  CB  . ALA A 1 4   ? 32.15614 -5.85410  -11.60294 1.000 37.19020 ? 2   ALA A CB  1 
ATOM   20   N  N   . GLU A 1 5   ? 35.02580 -7.07069  -10.74748 1.000 29.27424 ? 3   GLU A N   1 
ATOM   21   C  CA  . GLU A 1 5   ? 36.38125 -7.46964  -11.12001 1.000 33.72643 ? 3   GLU A CA  1 
ATOM   22   C  C   . GLU A 1 5   ? 36.68072 -8.89695  -10.68584 1.000 35.13300 ? 3   GLU A C   1 
ATOM   23   O  O   . GLU A 1 5   ? 37.39343 -9.62734  -11.38722 1.000 35.34021 ? 3   GLU A O   1 
ATOM   24   C  CB  . GLU A 1 5   ? 37.40074 -6.52100  -10.50355 1.000 31.52334 ? 3   GLU A CB  1 
ATOM   25   C  CG  . GLU A 1 5   ? 37.21931 -5.08082  -10.92197 1.000 35.25734 ? 3   GLU A CG  1 
ATOM   26   C  CD  . GLU A 1 5   ? 38.20621 -4.17285  -10.22095 1.000 38.31290 ? 3   GLU A CD  1 
ATOM   27   O  OE1 . GLU A 1 5   ? 38.23830 -4.19976  -8.97069  1.000 36.18933 ? 3   GLU A OE1 1 
ATOM   28   O  OE2 . GLU A 1 5   ? 38.93712 -3.43187  -10.90876 1.000 41.91050 ? 3   GLU A OE2 1 
ATOM   29   N  N   . LEU A 1 6   ? 36.17860 -9.29938  -9.51141  1.000 32.88342 ? 4   LEU A N   1 
ATOM   30   C  CA  . LEU A 1 6   ? 36.32086 -10.69312 -9.10089  1.000 30.81326 ? 4   LEU A CA  1 
ATOM   31   C  C   . LEU A 1 6   ? 35.59151 -11.60893 -10.06393 1.000 27.84632 ? 4   LEU A C   1 
ATOM   32   O  O   . LEU A 1 6   ? 36.11297 -12.66330 -10.44762 1.000 32.27078 ? 4   LEU A O   1 
ATOM   33   C  CB  . LEU A 1 6   ? 35.79684 -10.89720 -7.67999  1.000 26.53260 ? 4   LEU A CB  1 
ATOM   34   C  CG  . LEU A 1 6   ? 36.72612 -10.35118 -6.59296  1.000 34.45190 ? 4   LEU A CG  1 
ATOM   35   C  CD1 . LEU A 1 6   ? 35.97420 -10.16307 -5.26877  1.000 32.73573 ? 4   LEU A CD1 1 
ATOM   36   C  CD2 . LEU A 1 6   ? 37.97073 -11.23501 -6.43227  1.000 32.74872 ? 4   LEU A CD2 1 
ATOM   37   N  N   . LYS A 1 7   ? 34.37727 -11.22035 -10.46116 1.000 29.39833 ? 5   LYS A N   1 
ATOM   38   C  CA  . LYS A 1 7   ? 33.61292 -12.03231 -11.39661 1.000 29.91346 ? 5   LYS A CA  1 
ATOM   39   C  C   . LYS A 1 7   ? 34.37933 -12.24651 -12.69837 1.000 30.97593 ? 5   LYS A C   1 
ATOM   40   O  O   . LYS A 1 7   ? 34.24825 -13.30388 -13.32143 1.000 26.75222 ? 5   LYS A O   1 
ATOM   41   C  CB  . LYS A 1 7   ? 32.24789 -11.38758 -11.64918 1.000 30.65311 ? 5   LYS A CB  1 
ATOM   42   C  CG  . LYS A 1 7   ? 31.27466 -12.26214 -12.40756 1.000 32.03715 ? 5   LYS A CG  1 
ATOM   43   C  CD  . LYS A 1 7   ? 30.16052 -11.41927 -12.99449 1.000 37.98403 ? 5   LYS A CD  1 
ATOM   44   C  CE  . LYS A 1 7   ? 29.38091 -10.73721 -11.88748 1.000 37.98821 ? 5   LYS A CE  1 
ATOM   45   N  NZ  . LYS A 1 7   ? 27.99744 -10.35665 -12.31365 1.000 42.62093 ? 5   LYS A NZ  1 
ATOM   46   N  N   . GLN A 1 8   ? 35.21440 -11.28585 -13.11135 1.000 31.69964 ? 6   GLN A N   1 
ATOM   47   C  CA  . GLN A 1 8   ? 35.95207 -11.48475 -14.35803 1.000 31.39179 ? 6   GLN A CA  1 
ATOM   48   C  C   . GLN A 1 8   ? 37.08516 -12.49468 -14.18886 1.000 30.35293 ? 6   GLN A C   1 
ATOM   49   O  O   . GLN A 1 8   ? 37.35568 -13.28605 -15.10410 1.000 28.99465 ? 6   GLN A O   1 
ATOM   50   C  CB  . GLN A 1 8   ? 36.46338 -10.14863 -14.90715 1.000 35.56097 ? 6   GLN A CB  1 
ATOM   51   C  CG  . GLN A 1 8   ? 37.20723 -10.31090 -16.22319 1.000 36.26237 ? 6   GLN A CG  1 
ATOM   52   C  CD  . GLN A 1 8   ? 36.27971 -10.63667 -17.38052 1.000 39.84538 ? 6   GLN A CD  1 
ATOM   53   O  OE1 . GLN A 1 8   ? 36.52477 -11.59869 -18.12645 1.000 41.15536 ? 6   GLN A OE1 1 
ATOM   54   N  NE2 . GLN A 1 8   ? 35.19486 -9.87232  -17.52005 1.000 35.37893 ? 6   GLN A NE2 1 
ATOM   55   N  N   . GLU A 1 9   ? 37.74762 -12.51012 -13.02715 1.000 28.17848 ? 7   GLU A N   1 
ATOM   56   C  CA  . GLU A 1 9   ? 38.73142 -13.56080 -12.77897 1.000 27.60133 ? 7   GLU A CA  1 
ATOM   57   C  C   . GLU A 1 9   ? 38.07303 -14.93677 -12.72488 1.000 24.45147 ? 7   GLU A C   1 
ATOM   58   O  O   . GLU A 1 9   ? 38.64461 -15.92291 -13.20647 1.000 24.59131 ? 7   GLU A O   1 
ATOM   59   C  CB  . GLU A 1 9   ? 39.50093 -13.29289 -11.49008 1.000 36.62335 ? 7   GLU A CB  1 
ATOM   60   C  CG  . GLU A 1 9   ? 39.88778 -11.84044 -11.28248 1.000 41.53604 ? 7   GLU A CG  1 
ATOM   61   C  CD  . GLU A 1 9   ? 40.91908 -11.68198 -10.17952 1.000 48.23979 ? 7   GLU A CD  1 
ATOM   62   O  OE1 . GLU A 1 9   ? 41.81969 -10.82186 -10.32210 1.000 53.18395 ? 7   GLU A OE1 1 
ATOM   63   O  OE2 . GLU A 1 9   ? 40.82246 -12.41379 -9.17011  1.000 51.45148 ? 7   GLU A OE2 1 
ATOM   64   N  N   . TRP A 1 10  ? 36.88064 -15.02765 -12.13367 1.000 21.70958 ? 8   TRP A N   1 
ATOM   65   C  CA  . TRP A 1 10  ? 36.17446 -16.31035 -12.13679 1.000 19.19994 ? 8   TRP A CA  1 
ATOM   66   C  C   . TRP A 1 10  ? 35.78963 -16.71278 -13.54749 1.000 24.35433 ? 8   TRP A C   1 
ATOM   67   O  O   . TRP A 1 10  ? 35.86474 -17.89748 -13.90417 1.000 22.11459 ? 8   TRP A O   1 
ATOM   68   C  CB  . TRP A 1 10  ? 34.92879 -16.24961 -11.26802 1.000 20.46037 ? 8   TRP A CB  1 
ATOM   69   C  CG  . TRP A 1 10  ? 35.22550 -15.78752 -9.87805  1.000 20.42387 ? 8   TRP A CG  1 
ATOM   70   C  CD1 . TRP A 1 10  ? 36.39033 -15.96272 -9.19220  1.000 21.26718 ? 8   TRP A CD1 1 
ATOM   71   C  CD2 . TRP A 1 10  ? 34.34221 -15.07624 -9.00743  1.000 19.81239 ? 8   TRP A CD2 1 
ATOM   72   N  NE1 . TRP A 1 10  ? 36.28269 -15.40979 -7.93290  1.000 20.63688 ? 8   TRP A NE1 1 
ATOM   73   C  CE2 . TRP A 1 10  ? 35.03679 -14.85346 -7.79983  1.000 20.84529 ? 8   TRP A CE2 1 
ATOM   74   C  CE3 . TRP A 1 10  ? 33.03156 -14.61258 -9.12734  1.000 21.31416 ? 8   TRP A CE3 1 
ATOM   75   C  CZ2 . TRP A 1 10  ? 34.46330 -14.17493 -6.72257  1.000 18.67991 ? 8   TRP A CZ2 1 
ATOM   76   C  CZ3 . TRP A 1 10  ? 32.46245 -13.92730 -8.05853  1.000 23.61677 ? 8   TRP A CZ3 1 
ATOM   77   C  CH2 . TRP A 1 10  ? 33.18057 -13.72194 -6.86776  1.000 22.84690 ? 8   TRP A CH2 1 
ATOM   78   N  N   . ILE A 1 11  ? 35.34770 -15.74325 -14.35430 1.000 22.03771 ? 9   ILE A N   1 
ATOM   79   C  CA  . ILE A 1 11  ? 35.01750 -16.03369 -15.74851 1.000 21.67999 ? 9   ILE A CA  1 
ATOM   80   C  C   . ILE A 1 11  ? 36.24128 -16.56533 -16.47678 1.000 23.72815 ? 9   ILE A C   1 
ATOM   81   O  O   . ILE A 1 11  ? 36.16526 -17.55676 -17.21516 1.000 20.17150 ? 9   ILE A O   1 
ATOM   82   C  CB  . ILE A 1 11  ? 34.45018 -14.77943 -16.43185 1.000 23.47649 ? 9   ILE A CB  1 
ATOM   83   C  CG1 . ILE A 1 11  ? 33.04909 -14.47147 -15.90272 1.000 24.90483 ? 9   ILE A CG1 1 
ATOM   84   C  CG2 . ILE A 1 11  ? 34.38829 -14.97889 -17.94188 1.000 23.33959 ? 9   ILE A CG2 1 
ATOM   85   C  CD1 . ILE A 1 11  ? 32.53142 -13.09208 -16.30236 1.000 28.56471 ? 9   ILE A CD1 1 
ATOM   86   N  N   . ASN A 1 12  ? 37.39603 -15.93255 -16.26562 1.000 22.69144 ? 10  ASN A N   1 
ATOM   87   C  CA  . ASN A 1 12  ? 38.62173 -16.43232 -16.87209 1.000 24.33423 ? 10  ASN A CA  1 
ATOM   88   C  C   . ASN A 1 12  ? 38.90037 -17.86566 -16.45625 1.000 24.48905 ? 10  ASN A C   1 
ATOM   89   O  O   . ASN A 1 12  ? 39.27302 -18.69155 -17.29166 1.000 24.51976 ? 10  ASN A O   1 
ATOM   90   C  CB  . ASN A 1 12  ? 39.80001 -15.52173 -16.52048 1.000 29.23626 ? 10  ASN A CB  1 
ATOM   91   C  CG  . ASN A 1 12  ? 39.68153 -14.16606 -17.17750 1.000 29.60066 ? 10  ASN A CG  1 
ATOM   92   O  OD1 . ASN A 1 12  ? 38.92940 -14.00514 -18.13779 1.000 32.51289 ? 10  ASN A OD1 1 
ATOM   93   N  ND2 . ASN A 1 12  ? 40.41714 -13.18442 -16.66992 1.000 34.67098 ? 10  ASN A ND2 1 
ATOM   94   N  N   . THR A 1 13  ? 38.70978 -18.18648 -15.17305 1.000 19.73647 ? 11  THR A N   1 
ATOM   95   C  CA  . THR A 1 13  ? 38.92360 -19.55369 -14.70391 1.000 22.08122 ? 11  THR A CA  1 
ATOM   96   C  C   . THR A 1 13  ? 38.01704 -20.54040 -15.43009 1.000 19.46537 ? 11  THR A C   1 
ATOM   97   O  O   . THR A 1 13  ? 38.46360 -21.61520 -15.85912 1.000 21.53456 ? 11  THR A O   1 
ATOM   98   C  CB  . THR A 1 13  ? 38.67487 -19.62276 -13.19699 1.000 23.74532 ? 11  THR A CB  1 
ATOM   99   O  OG1 . THR A 1 13  ? 39.71218 -18.90179 -12.51965 1.000 24.08995 ? 11  THR A OG1 1 
ATOM   100  C  CG2 . THR A 1 13  ? 38.64537 -21.07556 -12.71616 1.000 22.08597 ? 11  THR A CG2 1 
ATOM   101  N  N   . ALA A 1 14  ? 36.74541 -20.19080 -15.59168 1.000 17.16024 ? 12  ALA A N   1 
ATOM   102  C  CA  . ALA A 1 14  ? 35.83027 -21.10701 -16.26008 1.000 15.85941 ? 12  ALA A CA  1 
ATOM   103  C  C   . ALA A 1 14  ? 36.17812 -21.24458 -17.73805 1.000 19.41265 ? 12  ALA A C   1 
ATOM   104  O  O   . ALA A 1 14  ? 36.06538 -22.33473 -18.31496 1.000 17.45389 ? 12  ALA A O   1 
ATOM   105  C  CB  . ALA A 1 14  ? 34.39445 -20.63186 -16.08482 1.000 16.72317 ? 12  ALA A CB  1 
ATOM   106  N  N   . ILE A 1 15  ? 36.59017 -20.14824 -18.37181 1.000 18.22625 ? 13  ILE A N   1 
ATOM   107  C  CA  . ILE A 1 15  ? 36.94449 -20.22425 -19.78404 1.000 20.34906 ? 13  ILE A CA  1 
ATOM   108  C  C   . ILE A 1 15  ? 38.21920 -21.04189 -19.97601 1.000 21.52107 ? 13  ILE A C   1 
ATOM   109  O  O   . ILE A 1 15  ? 38.30991 -21.84855 -20.91268 1.000 21.24955 ? 13  ILE A O   1 
ATOM   110  C  CB  . ILE A 1 15  ? 37.05474 -18.80738 -20.37873 1.000 19.45867 ? 13  ILE A CB  1 
ATOM   111  C  CG1 . ILE A 1 15  ? 35.65611 -18.19045 -20.51374 1.000 21.88615 ? 13  ILE A CG1 1 
ATOM   112  C  CG2 . ILE A 1 15  ? 37.73433 -18.85535 -21.75080 1.000 22.97272 ? 13  ILE A CG2 1 
ATOM   113  C  CD1 . ILE A 1 15  ? 35.66572 -16.71941 -20.91447 1.000 22.48495 ? 13  ILE A CD1 1 
ATOM   114  N  N   . GLU A 1 16  ? 39.21757 -20.87841 -19.09049 1.000 19.29725 ? 14  GLU A N   1 
ATOM   115  C  CA  . GLU A 1 16  ? 40.41110 -21.71569 -19.21146 1.000 22.21297 ? 14  GLU A CA  1 
ATOM   116  C  C   . GLU A 1 16  ? 40.09089 -23.18691 -19.03822 1.000 21.35479 ? 14  GLU A C   1 
ATOM   117  O  O   . GLU A 1 16  ? 40.76556 -24.03374 -19.62994 1.000 21.14569 ? 14  GLU A O   1 
ATOM   118  C  CB  . GLU A 1 16  ? 41.52308 -21.32579 -18.22714 1.000 26.95524 ? 14  GLU A CB  1 
ATOM   119  C  CG  . GLU A 1 16  ? 41.74268 -19.85458 -18.05200 1.000 30.66033 ? 14  GLU A CG  1 
ATOM   120  C  CD  . GLU A 1 16  ? 42.77631 -19.52353 -17.00233 1.000 39.12535 ? 14  GLU A CD  1 
ATOM   121  O  OE1 . GLU A 1 16  ? 42.72905 -20.11834 -15.89848 1.000 40.26276 ? 14  GLU A OE1 1 
ATOM   122  O  OE2 . GLU A 1 16  ? 43.60105 -18.62266 -17.26517 1.000 43.52409 ? 14  GLU A OE2 1 
ATOM   123  N  N   . ALA A 1 17  ? 39.06755 -23.51324 -18.24553 1.000 20.73210 ? 15  ALA A N   1 
ATOM   124  C  CA  . ALA A 1 17  ? 38.69505 -24.91319 -18.08551 1.000 20.42346 ? 15  ALA A CA  1 
ATOM   125  C  C   . ALA A 1 17  ? 38.25719 -25.54593 -19.40570 1.000 20.38612 ? 15  ALA A C   1 
ATOM   126  O  O   . ALA A 1 17  ? 38.36225 -26.77009 -19.55234 1.000 17.76916 ? 15  ALA A O   1 
ATOM   127  C  CB  . ALA A 1 17  ? 37.58824 -25.04101 -17.03053 1.000 17.69216 ? 15  ALA A CB  1 
ATOM   128  N  N   . LEU A 1 18  ? 37.77742 -24.74798 -20.37047 1.000 19.97391 ? 16  LEU A N   1 
ATOM   129  C  CA  . LEU A 1 18  ? 37.35776 -25.32163 -21.65128 1.000 19.61272 ? 16  LEU A CA  1 
ATOM   130  C  C   . LEU A 1 18  ? 38.49329 -26.06499 -22.33078 1.000 24.54492 ? 16  LEU A C   1 
ATOM   131  O  O   . LEU A 1 18  ? 38.25108 -27.00279 -23.10173 1.000 23.25014 ? 16  LEU A O   1 
ATOM   132  C  CB  . LEU A 1 18  ? 36.82406 -24.24136 -22.58631 1.000 21.36020 ? 16  LEU A CB  1 
ATOM   133  C  CG  . LEU A 1 18  ? 35.55468 -23.51435 -22.14408 1.000 17.99089 ? 16  LEU A CG  1 
ATOM   134  C  CD1 . LEU A 1 18  ? 35.32821 -22.27014 -23.02260 1.000 19.33779 ? 16  LEU A CD1 1 
ATOM   135  C  CD2 . LEU A 1 18  ? 34.36429 -24.46435 -22.18934 1.000 18.83887 ? 16  LEU A CD2 1 
ATOM   136  N  N   . ASP A 1 19  ? 39.73015 -25.65882 -22.06373 1.000 23.91887 ? 17  ASP A N   1 
ATOM   137  C  CA  . ASP A 1 19  ? 40.89994 -26.27058 -22.67257 1.000 25.13729 ? 17  ASP A CA  1 
ATOM   138  C  C   . ASP A 1 19  ? 41.35587 -27.51548 -21.92895 1.000 26.13483 ? 17  ASP A C   1 
ATOM   139  O  O   . ASP A 1 19  ? 42.21102 -28.24642 -22.43981 1.000 26.22598 ? 17  ASP A O   1 
ATOM   140  C  CB  . ASP A 1 19  ? 42.02899 -25.24100 -22.71592 1.000 27.47302 ? 17  ASP A CB  1 
ATOM   141  C  CG  . ASP A 1 19  ? 41.77765 -24.17655 -23.74891 1.000 33.72911 ? 17  ASP A CG  1 
ATOM   142  O  OD1 . ASP A 1 19  ? 41.49153 -24.52451 -24.91409 1.000 34.82184 ? 17  ASP A OD1 1 
ATOM   143  O  OD2 . ASP A 1 19  ? 41.80383 -22.98532 -23.37941 1.000 38.01586 ? 17  ASP A OD2 1 
ATOM   144  N  N   . LYS A 1 20  ? 40.78882 -27.78438 -20.75035 1.000 22.69674 ? 18  LYS A N   1 
ATOM   145  C  CA  . LYS A 1 20  ? 41.16267 -28.93250 -19.94670 1.000 19.38890 ? 18  LYS A CA  1 
ATOM   146  C  C   . LYS A 1 20  ? 40.11725 -30.03672 -19.96482 1.000 17.74889 ? 18  LYS A C   1 
ATOM   147  O  O   . LYS A 1 20  ? 40.31449 -31.05225 -19.29305 1.000 17.81011 ? 18  LYS A O   1 
ATOM   148  C  CB  . LYS A 1 20  ? 41.40941 -28.51863 -18.48646 1.000 22.18441 ? 18  LYS A CB  1 
ATOM   149  C  CG  . LYS A 1 20  ? 42.42012 -27.38596 -18.30248 1.000 26.16712 ? 18  LYS A CG  1 
ATOM   150  C  CD  . LYS A 1 20  ? 42.33065 -26.82903 -16.89117 1.000 28.00215 ? 18  LYS A CD  1 
ATOM   151  C  CE  . LYS A 1 20  ? 43.65955 -26.29244 -16.38630 1.000 32.39715 ? 18  LYS A CE  1 
ATOM   152  N  NZ  . LYS A 1 20  ? 43.64756 -26.02792 -14.91315 1.000 27.35332 ? 18  LYS A NZ  1 
ATOM   153  N  N   . ALA A 1 21  ? 39.01977 -29.86105 -20.69958 1.000 16.45034 ? 19  ALA A N   1 
ATOM   154  C  CA  . ALA A 1 21  ? 37.90165 -30.79458 -20.62486 1.000 18.27043 ? 19  ALA A CA  1 
ATOM   155  C  C   . ALA A 1 21  ? 38.28281 -32.13825 -21.22953 1.000 17.15938 ? 19  ALA A C   1 
ATOM   156  O  O   . ALA A 1 21  ? 39.11997 -32.22171 -22.13778 1.000 18.19994 ? 19  ALA A O   1 
ATOM   157  C  CB  . ALA A 1 21  ? 36.68147 -30.23453 -21.35707 1.000 17.20806 ? 19  ALA A CB  1 
ATOM   158  N  N   . TYR A 1 22  ? 37.67715 -33.20421 -20.70162 1.000 14.13491 ? 20  TYR A N   1 
ATOM   159  C  CA  . TYR A 1 22  ? 37.84579 -34.55015 -21.26123 1.000 16.52478 ? 20  TYR A CA  1 
ATOM   160  C  C   . TYR A 1 22  ? 36.56270 -34.88054 -22.02431 1.000 18.29924 ? 20  TYR A C   1 
ATOM   161  O  O   . TYR A 1 22  ? 35.60305 -35.42930 -21.46925 1.000 15.12886 ? 20  TYR A O   1 
ATOM   162  C  CB  . TYR A 1 22  ? 38.16244 -35.56756 -20.16861 1.000 15.82474 ? 20  TYR A CB  1 
ATOM   163  C  CG  . TYR A 1 22  ? 38.31398 -36.98581 -20.68189 1.000 16.99516 ? 20  TYR A CG  1 
ATOM   164  C  CD1 . TYR A 1 22  ? 39.45986 -37.37505 -21.36096 1.000 20.11192 ? 20  TYR A CD1 1 
ATOM   165  C  CD2 . TYR A 1 22  ? 37.30685 -37.93837 -20.48305 1.000 16.32845 ? 20  TYR A CD2 1 
ATOM   166  C  CE1 . TYR A 1 22  ? 39.60845 -38.66621 -21.84754 1.000 20.33861 ? 20  TYR A CE1 1 
ATOM   167  C  CE2 . TYR A 1 22  ? 37.44630 -39.24209 -20.96174 1.000 15.18614 ? 20  TYR A CE2 1 
ATOM   168  C  CZ  . TYR A 1 22  ? 38.60379 -39.59434 -21.64286 1.000 23.94732 ? 20  TYR A CZ  1 
ATOM   169  O  OH  . TYR A 1 22  ? 38.76095 -40.87895 -22.12193 1.000 21.84436 ? 20  TYR A OH  1 
ATOM   170  N  N   . VAL A 1 23  ? 36.54421 -34.54028 -23.31436 1.000 14.21721 ? 21  VAL A N   1 
ATOM   171  C  CA  . VAL A 1 23  ? 35.33823 -34.72838 -24.11929 1.000 13.70527 ? 21  VAL A CA  1 
ATOM   172  C  C   . VAL A 1 23  ? 35.68300 -35.41424 -25.43862 1.000 17.67193 ? 21  VAL A C   1 
ATOM   173  O  O   . VAL A 1 23  ? 35.34050 -34.88781 -26.50267 1.000 17.65608 ? 21  VAL A O   1 
ATOM   174  C  CB  . VAL A 1 23  ? 34.60149 -33.40025 -24.36801 1.000 16.69264 ? 21  VAL A CB  1 
ATOM   175  C  CG1 . VAL A 1 23  ? 33.88846 -32.94049 -23.06383 1.000 16.06810 ? 21  VAL A CG1 1 
ATOM   176  C  CG2 . VAL A 1 23  ? 35.55484 -32.31067 -24.86398 1.000 18.60314 ? 21  VAL A CG2 1 
ATOM   177  N  N   . PRO A 1 24  ? 36.29197 -36.60382 -25.41983 1.000 18.26855 ? 22  PRO A N   1 
ATOM   178  C  CA  . PRO A 1 24  ? 36.62497 -37.27301 -26.69122 1.000 18.68573 ? 22  PRO A CA  1 
ATOM   179  C  C   . PRO A 1 24  ? 35.41717 -37.76361 -27.48204 1.000 21.57833 ? 22  PRO A C   1 
ATOM   180  O  O   . PRO A 1 24  ? 35.59133 -38.15734 -28.64576 1.000 21.98265 ? 22  PRO A O   1 
ATOM   181  C  CB  . PRO A 1 24  ? 37.51337 -38.43361 -26.24668 1.000 19.79583 ? 22  PRO A CB  1 
ATOM   182  C  CG  . PRO A 1 24  ? 37.04492 -38.75443 -24.86239 1.000 19.21743 ? 22  PRO A CG  1 
ATOM   183  C  CD  . PRO A 1 24  ? 36.69810 -37.41367 -24.25463 1.000 18.68456 ? 22  PRO A CD  1 
ATOM   184  N  N   . TYR A 1 25  ? 34.20376 -37.73620 -26.92702 1.000 17.35168 ? 23  TYR A N   1 
ATOM   185  C  CA  . TYR A 1 25  ? 33.04191 -38.23587 -27.65256 1.000 18.54388 ? 23  TYR A CA  1 
ATOM   186  C  C   . TYR A 1 25  ? 32.13350 -37.13470 -28.17740 1.000 20.88935 ? 23  TYR A C   1 
ATOM   187  O  O   . TYR A 1 25  ? 31.72909 -37.17663 -29.34041 1.000 24.62001 ? 23  TYR A O   1 
ATOM   188  C  CB  . TYR A 1 25  ? 32.26237 -39.22267 -26.76097 1.000 19.32622 ? 23  TYR A CB  1 
ATOM   189  C  CG  . TYR A 1 25  ? 33.21798 -40.19683 -26.11851 1.000 20.20397 ? 23  TYR A CG  1 
ATOM   190  C  CD1 . TYR A 1 25  ? 33.98200 -41.05177 -26.90006 1.000 21.22716 ? 23  TYR A CD1 1 
ATOM   191  C  CD2 . TYR A 1 25  ? 33.39395 -40.23302 -24.73995 1.000 16.46730 ? 23  TYR A CD2 1 
ATOM   192  C  CE1 . TYR A 1 25  ? 34.87674 -41.92317 -26.32946 1.000 21.26356 ? 23  TYR A CE1 1 
ATOM   193  C  CE2 . TYR A 1 25  ? 34.28764 -41.10266 -24.16295 1.000 16.29407 ? 23  TYR A CE2 1 
ATOM   194  C  CZ  . TYR A 1 25  ? 35.03078 -41.94756 -24.96613 1.000 20.85128 ? 23  TYR A CZ  1 
ATOM   195  O  OH  . TYR A 1 25  ? 35.92987 -42.81976 -24.39033 1.000 21.23634 ? 23  TYR A OH  1 
ATOM   196  N  N   . SER A 1 26  ? 31.79722 -36.13619 -27.36466 1.000 19.08015 ? 24  SER A N   1 
ATOM   197  C  CA  . SER A 1 26  ? 31.00022 -35.02255 -27.85305 1.000 17.80797 ? 24  SER A CA  1 
ATOM   198  C  C   . SER A 1 26  ? 31.83787 -33.92843 -28.48964 1.000 15.77775 ? 24  SER A C   1 
ATOM   199  O  O   . SER A 1 26  ? 31.32386 -33.16709 -29.31089 1.000 17.75241 ? 24  SER A O   1 
ATOM   200  C  CB  . SER A 1 26  ? 30.20766 -34.38611 -26.70639 1.000 20.30195 ? 24  SER A CB  1 
ATOM   201  O  OG  . SER A 1 26  ? 31.08406 -33.64294 -25.86724 1.000 17.00350 ? 24  SER A OG  1 
ATOM   202  N  N   . HIS A 1 27  ? 33.08314 -33.78818 -28.05974 1.000 17.19720 ? 25  HIS A N   1 
ATOM   203  C  CA  . HIS A 1 27  ? 33.94711 -32.68603 -28.47502 1.000 16.90918 ? 25  HIS A CA  1 
ATOM   204  C  C   . HIS A 1 27  ? 33.33155 -31.33591 -28.12563 1.000 22.24263 ? 25  HIS A C   1 
ATOM   205  O  O   . HIS A 1 27  ? 33.57201 -30.33366 -28.79675 1.000 19.87783 ? 25  HIS A O   1 
ATOM   206  C  CB  . HIS A 1 27  ? 34.25472 -32.80501 -29.96760 1.000 19.09987 ? 25  HIS A CB  1 
ATOM   207  C  CG  . HIS A 1 27  ? 35.17325 -33.94026 -30.23861 1.000 24.32179 ? 25  HIS A CG  1 
ATOM   208  N  ND1 . HIS A 1 27  ? 36.51577 -33.77763 -30.49977 1.000 31.16745 ? 25  HIS A ND1 1 
ATOM   209  C  CD2 . HIS A 1 27  ? 34.94963 -35.27102 -30.21558 1.000 24.75878 ? 25  HIS A CD2 1 
ATOM   210  C  CE1 . HIS A 1 27  ? 37.07619 -34.96554 -30.64030 1.000 30.56271 ? 25  HIS A CE1 1 
ATOM   211  N  NE2 . HIS A 1 27  ? 36.14618 -35.88697 -30.46878 1.000 26.10413 ? 25  HIS A NE2 1 
ATOM   212  N  N   . PHE A 1 28  ? 32.54603 -31.31330 -27.04399 1.000 17.83253 ? 26  PHE A N   1 
ATOM   213  C  CA  . PHE A 1 28  ? 31.81155 -30.13748 -26.57661 1.000 17.22979 ? 26  PHE A CA  1 
ATOM   214  C  C   . PHE A 1 28  ? 32.27117 -29.84000 -25.15040 1.000 18.82901 ? 26  PHE A C   1 
ATOM   215  O  O   . PHE A 1 28  ? 31.70913 -30.38095 -24.18183 1.000 16.51502 ? 26  PHE A O   1 
ATOM   216  C  CB  . PHE A 1 28  ? 30.30470 -30.40477 -26.62682 1.000 17.01648 ? 26  PHE A CB  1 
ATOM   217  C  CG  . PHE A 1 28  ? 29.44629 -29.22214 -26.27528 1.000 17.65166 ? 26  PHE A CG  1 
ATOM   218  C  CD1 . PHE A 1 28  ? 29.14626 -28.25638 -27.22196 1.000 18.65792 ? 26  PHE A CD1 1 
ATOM   219  C  CD2 . PHE A 1 28  ? 28.91726 -29.08266 -24.98546 1.000 16.23863 ? 26  PHE A CD2 1 
ATOM   220  C  CE1 . PHE A 1 28  ? 28.34922 -27.16554 -26.89799 1.000 21.81118 ? 26  PHE A CE1 1 
ATOM   221  C  CE2 . PHE A 1 28  ? 28.12785 -28.00218 -24.65996 1.000 18.24044 ? 26  PHE A CE2 1 
ATOM   222  C  CZ  . PHE A 1 28  ? 27.84565 -27.03438 -25.60875 1.000 19.43368 ? 26  PHE A CZ  1 
ATOM   223  N  N   . PRO A 1 29  ? 33.28777 -29.00073 -24.97033 1.000 18.57808 ? 27  PRO A N   1 
ATOM   224  C  CA  . PRO A 1 29  ? 33.79800 -28.72807 -23.62162 1.000 16.82135 ? 27  PRO A CA  1 
ATOM   225  C  C   . PRO A 1 29  ? 32.94045 -27.73052 -22.86377 1.000 16.30264 ? 27  PRO A C   1 
ATOM   226  O  O   . PRO A 1 29  ? 32.33179 -26.81850 -23.43890 1.000 16.87203 ? 27  PRO A O   1 
ATOM   227  C  CB  . PRO A 1 29  ? 35.18784 -28.13537 -23.88807 1.000 16.69086 ? 27  PRO A CB  1 
ATOM   228  C  CG  . PRO A 1 29  ? 35.01326 -27.41956 -25.20634 1.000 18.95017 ? 27  PRO A CG  1 
ATOM   229  C  CD  . PRO A 1 29  ? 34.06151 -28.29644 -26.01273 1.000 18.04701 ? 27  PRO A CD  1 
ATOM   230  N  N   . VAL A 1 30  ? 32.93002 -27.90209 -21.53968 1.000 14.70033 ? 28  VAL A N   1 
ATOM   231  C  CA  . VAL A 1 30  ? 32.23630 -26.99734 -20.63057 1.000 16.91591 ? 28  VAL A CA  1 
ATOM   232  C  C   . VAL A 1 30  ? 33.16712 -26.76536 -19.45187 1.000 15.68646 ? 28  VAL A C   1 
ATOM   233  O  O   . VAL A 1 30  ? 33.87077 -27.68465 -19.01588 1.000 14.53842 ? 28  VAL A O   1 
ATOM   234  C  CB  . VAL A 1 30  ? 30.86976 -27.56295 -20.16817 1.000 16.17155 ? 28  VAL A CB  1 
ATOM   235  C  CG1 . VAL A 1 30  ? 30.15500 -26.55604 -19.27182 1.000 16.89262 ? 28  VAL A CG1 1 
ATOM   236  C  CG2 . VAL A 1 30  ? 29.98898 -27.86199 -21.35783 1.000 17.64764 ? 28  VAL A CG2 1 
ATOM   237  N  N   . GLY A 1 31  ? 33.21552 -25.52491 -18.97056 1.000 14.62861 ? 29  GLY A N   1 
ATOM   238  C  CA  . GLY A 1 31  ? 34.09714 -25.15479 -17.88114 1.000 15.05469 ? 29  GLY A CA  1 
ATOM   239  C  C   . GLY A 1 31  ? 33.30488 -24.51596 -16.75548 1.000 14.86513 ? 29  GLY A C   1 
ATOM   240  O  O   . GLY A 1 31  ? 32.23353 -23.94260 -16.97147 1.000 16.19318 ? 29  GLY A O   1 
ATOM   241  N  N   . ALA A 1 32  ? 33.83142 -24.63300 -15.53966 1.000 15.97752 ? 30  ALA A N   1 
ATOM   242  C  CA  . ALA A 1 32  ? 33.12279 -24.08633 -14.38583 1.000 16.14781 ? 30  ALA A CA  1 
ATOM   243  C  C   . ALA A 1 32  ? 34.11279 -23.50845 -13.38884 1.000 17.02536 ? 30  ALA A C   1 
ATOM   244  O  O   . ALA A 1 32  ? 35.26070 -23.95741 -13.28716 1.000 15.21277 ? 30  ALA A O   1 
ATOM   245  C  CB  . ALA A 1 32  ? 32.24992 -25.15333 -13.68729 1.000 15.71096 ? 30  ALA A CB  1 
ATOM   246  N  N   . CYS A 1 33  ? 33.65377 -22.49048 -12.65370 1.000 16.02700 ? 31  CYS A N   1 
ATOM   247  C  CA  . CYS A 1 33  ? 34.41868 -21.89685 -11.55705 1.000 16.85958 ? 31  CYS A CA  1 
ATOM   248  C  C   . CYS A 1 33  ? 33.45479 -21.73393 -10.39460 1.000 15.61648 ? 31  CYS A C   1 
ATOM   249  O  O   . CYS A 1 33  ? 32.53285 -20.91108 -10.46475 1.000 16.74761 ? 31  CYS A O   1 
ATOM   250  C  CB  . CYS A 1 33  ? 35.03284 -20.55072 -11.95338 1.000 17.00776 ? 31  CYS A CB  1 
ATOM   251  S  SG  . CYS A 1 33  ? 35.95706 -19.79116 -10.59554 1.000 18.86226 ? 31  CYS A SG  1 
ATOM   252  N  N   . LEU A 1 34  ? 33.65417 -22.53558 -9.34554  1.000 16.62091 ? 32  LEU A N   1 
ATOM   253  C  CA  . LEU A 1 34  ? 32.81066 -22.53045 -8.15752  1.000 14.77176 ? 32  LEU A CA  1 
ATOM   254  C  C   . LEU A 1 34  ? 33.57804 -21.82581 -7.04452  1.000 15.99767 ? 32  LEU A C   1 
ATOM   255  O  O   . LEU A 1 34  ? 34.72859 -22.17834 -6.76926  1.000 15.98505 ? 32  LEU A O   1 
ATOM   256  C  CB  . LEU A 1 34  ? 32.44261 -23.96142 -7.74671  1.000 15.91234 ? 32  LEU A CB  1 
ATOM   257  C  CG  . LEU A 1 34  ? 31.64187 -24.13351 -6.45374  1.000 18.26881 ? 32  LEU A CG  1 
ATOM   258  C  CD1 . LEU A 1 34  ? 30.27900 -23.40047 -6.52511  1.000 14.37240 ? 32  LEU A CD1 1 
ATOM   259  C  CD2 . LEU A 1 34  ? 31.42776 -25.62439 -6.17871  1.000 18.03535 ? 32  LEU A CD2 1 
ATOM   260  N  N   . VAL A 1 35  ? 32.95854 -20.81606 -6.43359  1.000 17.36172 ? 33  VAL A N   1 
ATOM   261  C  CA  . VAL A 1 35  ? 33.65059 -19.91514 -5.50853  1.000 17.01152 ? 33  VAL A CA  1 
ATOM   262  C  C   . VAL A 1 35  ? 33.07915 -20.11374 -4.11449  1.000 15.54368 ? 33  VAL A C   1 
ATOM   263  O  O   . VAL A 1 35  ? 31.85308 -20.12114 -3.93945  1.000 17.53803 ? 33  VAL A O   1 
ATOM   264  C  CB  . VAL A 1 35  ? 33.50932 -18.44623 -5.93555  1.000 20.99151 ? 33  VAL A CB  1 
ATOM   265  C  CG1 . VAL A 1 35  ? 34.42873 -17.58291 -5.07512  1.000 22.00457 ? 33  VAL A CG1 1 
ATOM   266  C  CG2 . VAL A 1 35  ? 33.81655 -18.28558 -7.43179  1.000 20.68674 ? 33  VAL A CG2 1 
ATOM   267  N  N   . THR A 1 36  ? 33.96090 -20.27380 -3.12517  1.000 16.18220 ? 34  THR A N   1 
ATOM   268  C  CA  . THR A 1 36  ? 33.51233 -20.44059 -1.74756  1.000 17.95098 ? 34  THR A CA  1 
ATOM   269  C  C   . THR A 1 36  ? 33.49613 -19.10550 -1.00882  1.000 17.63310 ? 34  THR A C   1 
ATOM   270  O  O   . THR A 1 36  ? 34.09168 -18.10812 -1.42183  1.000 16.95489 ? 34  THR A O   1 
ATOM   271  C  CB  . THR A 1 36  ? 34.38864 -21.42855 -0.96022  1.000 17.35857 ? 34  THR A CB  1 
ATOM   272  O  OG1 . THR A 1 36  ? 35.67574 -20.84576 -0.71139  1.000 16.63352 ? 34  THR A OG1 1 
ATOM   273  C  CG2 . THR A 1 36  ? 34.55542 -22.76360 -1.70644  1.000 16.69227 ? 34  THR A CG2 1 
ATOM   274  N  N   . GLU A 1 37  ? 32.80071 -19.13419 0.12800   1.000 17.01612 ? 35  GLU A N   1 
ATOM   275  C  CA  . GLU A 1 37  ? 32.71178 -18.00708 1.04474   1.000 22.19394 ? 35  GLU A CA  1 
ATOM   276  C  C   . GLU A 1 37  ? 34.08046 -17.59710 1.57491   1.000 16.78506 ? 35  GLU A C   1 
ATOM   277  O  O   . GLU A 1 37  ? 34.29601 -16.42430 1.91894   1.000 17.24078 ? 35  GLU A O   1 
ATOM   278  C  CB  . GLU A 1 37  ? 31.76019 -18.45128 2.14903   1.000 22.63641 ? 35  GLU A CB  1 
ATOM   279  C  CG  . GLU A 1 37  ? 31.59800 -17.66308 3.37129   1.000 29.68341 ? 35  GLU A CG  1 
ATOM   280  C  CD  . GLU A 1 37  ? 30.51871 -18.30876 4.22524   1.000 26.32954 ? 35  GLU A CD  1 
ATOM   281  O  OE1 . GLU A 1 37  ? 29.32112 -18.05308 3.94635   1.000 29.55745 ? 35  GLU A OE1 1 
ATOM   282  O  OE2 . GLU A 1 37  ? 30.88489 -19.07401 5.15509   1.000 28.15783 ? 35  GLU A OE2 1 
ATOM   283  N  N   . SER A 1 38  ? 35.02757 -18.53039 1.61018   1.000 17.26209 ? 36  SER A N   1 
ATOM   284  C  CA  . SER A 1 38  ? 36.39284 -18.25917 2.03534   1.000 18.71980 ? 36  SER A CA  1 
ATOM   285  C  C   . SER A 1 38  ? 37.28271 -17.74168 0.91198   1.000 20.96399 ? 36  SER A C   1 
ATOM   286  O  O   . SER A 1 38  ? 38.47023 -17.48458 1.14772   1.000 21.01250 ? 36  SER A O   1 
ATOM   287  C  CB  . SER A 1 38  ? 36.99914 -19.53516 2.64474   1.000 22.43932 ? 36  SER A CB  1 
ATOM   288  O  OG  . SER A 1 38  ? 37.24496 -20.52231 1.64935   1.000 27.75971 ? 36  SER A OG  1 
ATOM   289  N  N   . GLY A 1 39  ? 36.74683 -17.56143 -0.29833  1.000 17.97841 ? 37  GLY A N   1 
ATOM   290  C  CA  . GLY A 1 39  ? 37.52220 -17.04368 -1.40161  1.000 21.26053 ? 37  GLY A CA  1 
ATOM   291  C  C   . GLY A 1 39  ? 38.17929 -18.09506 -2.27074  1.000 23.89175 ? 37  GLY A C   1 
ATOM   292  O  O   . GLY A 1 39  ? 38.74714 -17.75429 -3.31853  1.000 24.83725 ? 37  GLY A O   1 
ATOM   293  N  N   . LYS A 1 40  ? 38.12429 -19.35872 -1.88461  1.000 17.61101 ? 38  LYS A N   1 
ATOM   294  C  CA  . LYS A 1 40  ? 38.79759 -20.39493 -2.65115  1.000 18.44576 ? 38  LYS A CA  1 
ATOM   295  C  C   . LYS A 1 40  ? 37.97586 -20.72808 -3.88592  1.000 20.97466 ? 38  LYS A C   1 
ATOM   296  O  O   . LYS A 1 40  ? 36.74749 -20.79371 -3.82293  1.000 21.93789 ? 38  LYS A O   1 
ATOM   297  C  CB  . LYS A 1 40  ? 38.98103 -21.65053 -1.79821  1.000 19.07740 ? 38  LYS A CB  1 
ATOM   298  C  CG  . LYS A 1 40  ? 39.86682 -22.71220 -2.45857  1.000 21.81288 ? 38  LYS A CG  1 
ATOM   299  C  CD  . LYS A 1 40  ? 40.24594 -23.77643 -1.45345  1.000 23.81371 ? 38  LYS A CD  1 
ATOM   300  C  CE  . LYS A 1 40  ? 41.15898 -24.83513 -2.08138  1.000 23.46624 ? 38  LYS A CE  1 
ATOM   301  N  NZ  . LYS A 1 40  ? 41.27333 -26.07181 -1.25562  1.000 25.78796 ? 38  LYS A NZ  1 
ATOM   302  N  N   . ILE A 1 41  ? 38.64444 -20.93981 -5.01454  1.000 18.97084 ? 39  ILE A N   1 
ATOM   303  C  CA  . ILE A 1 41  ? 37.91937 -21.33089 -6.21501  1.000 22.23057 ? 39  ILE A CA  1 
ATOM   304  C  C   . ILE A 1 41  ? 38.22017 -22.78697 -6.54949  1.000 19.42417 ? 39  ILE A C   1 
ATOM   305  O  O   . ILE A 1 41  ? 39.32077 -23.30403 -6.30988  1.000 19.41454 ? 39  ILE A O   1 
ATOM   306  C  CB  . ILE A 1 41  ? 38.21927 -20.39545 -7.39961  1.000 23.83684 ? 39  ILE A CB  1 
ATOM   307  C  CG1 . ILE A 1 41  ? 39.60576 -20.65067 -7.94372  1.000 28.23355 ? 39  ILE A CG1 1 
ATOM   308  C  CG2 . ILE A 1 41  ? 38.02663 -18.91973 -6.99906  1.000 23.63709 ? 39  ILE A CG2 1 
ATOM   309  C  CD1 . ILE A 1 41  ? 39.55992 -21.37931 -9.24308  1.000 29.60289 ? 39  ILE A CD1 1 
ATOM   310  N  N   . TYR A 1 42  ? 37.20617 -23.44961 -7.09983  1.000 19.02289 ? 40  TYR A N   1 
ATOM   311  C  CA  . TYR A 1 42  ? 37.30226 -24.81843 -7.58090  1.000 17.85516 ? 40  TYR A CA  1 
ATOM   312  C  C   . TYR A 1 42  ? 36.92397 -24.81451 -9.05349  1.000 17.25935 ? 40  TYR A C   1 
ATOM   313  O  O   . TYR A 1 42  ? 35.83219 -24.36614 -9.41601  1.000 17.93729 ? 40  TYR A O   1 
ATOM   314  C  CB  . TYR A 1 42  ? 36.38653 -25.73837 -6.77593  1.000 15.34804 ? 40  TYR A CB  1 
ATOM   315  C  CG  . TYR A 1 42  ? 36.89868 -25.92546 -5.37001  1.000 15.63169 ? 40  TYR A CG  1 
ATOM   316  C  CD1 . TYR A 1 42  ? 36.57302 -25.01344 -4.36420  1.000 18.87180 ? 40  TYR A CD1 1 
ATOM   317  C  CD2 . TYR A 1 42  ? 37.74429 -26.98737 -5.05641  1.000 16.96428 ? 40  TYR A CD2 1 
ATOM   318  C  CE1 . TYR A 1 42  ? 37.05604 -25.18130 -3.06822  1.000 19.12966 ? 40  TYR A CE1 1 
ATOM   319  C  CE2 . TYR A 1 42  ? 38.22997 -27.15568 -3.77399  1.000 19.82061 ? 40  TYR A CE2 1 
ATOM   320  C  CZ  . TYR A 1 42  ? 37.87975 -26.25017 -2.78432  1.000 21.10711 ? 40  TYR A CZ  1 
ATOM   321  O  OH  . TYR A 1 42  ? 38.36332 -26.43995 -1.50535  1.000 19.13803 ? 40  TYR A OH  1 
ATOM   322  N  N   . GLN A 1 43  ? 37.83233 -25.29226 -9.89466  1.000 15.43334 ? 41  GLN A N   1 
ATOM   323  C  CA  . GLN A 1 43  ? 37.61488 -25.33054 -11.33371 1.000 14.74176 ? 41  GLN A CA  1 
ATOM   324  C  C   . GLN A 1 43  ? 37.04049 -26.68717 -11.72394 1.000 16.10280 ? 41  GLN A C   1 
ATOM   325  O  O   . GLN A 1 43  ? 37.52781 -27.72064 -11.25935 1.000 16.15800 ? 41  GLN A O   1 
ATOM   326  C  CB  . GLN A 1 43  ? 38.93296 -25.10088 -12.06294 1.000 18.05101 ? 41  GLN A CB  1 
ATOM   327  C  CG  . GLN A 1 43  ? 38.80378 -24.94326 -13.55960 1.000 17.35808 ? 41  GLN A CG  1 
ATOM   328  C  CD  . GLN A 1 43  ? 40.15798 -24.76420 -14.20908 1.000 21.07033 ? 41  GLN A CD  1 
ATOM   329  O  OE1 . GLN A 1 43  ? 41.05547 -25.59900 -14.04860 1.000 21.93623 ? 41  GLN A OE1 1 
ATOM   330  N  NE2 . GLN A 1 43  ? 40.32994 -23.65496 -14.92265 1.000 17.76489 ? 41  GLN A NE2 1 
ATOM   331  N  N   . GLY A 1 44  ? 36.01447 -26.68109 -12.56412 1.000 15.64280 ? 42  GLY A N   1 
ATOM   332  C  CA  . GLY A 1 44  ? 35.37514 -27.90745 -13.01065 1.000 18.11800 ? 42  GLY A CA  1 
ATOM   333  C  C   . GLY A 1 44  ? 35.51154 -28.06638 -14.51294 1.000 15.05413 ? 42  GLY A C   1 
ATOM   334  O  O   . GLY A 1 44  ? 35.57363 -27.08332 -15.25151 1.000 15.29867 ? 42  GLY A O   1 
ATOM   335  N  N   . ILE A 1 45  ? 35.54797 -29.32712 -14.96173 1.000 14.87013 ? 43  ILE A N   1 
ATOM   336  C  CA  . ILE A 1 45  ? 35.53921 -29.68738 -16.37916 1.000 14.21025 ? 43  ILE A CA  1 
ATOM   337  C  C   . ILE A 1 45  ? 34.52387 -30.80200 -16.56026 1.000 13.54180 ? 43  ILE A C   1 
ATOM   338  O  O   . ILE A 1 45  ? 34.28793 -31.59681 -15.64342 1.000 13.81345 ? 43  ILE A O   1 
ATOM   339  C  CB  . ILE A 1 45  ? 36.92078 -30.17280 -16.89548 1.000 15.04573 ? 43  ILE A CB  1 
ATOM   340  C  CG1 . ILE A 1 45  ? 37.44015 -31.34841 -16.05886 1.000 16.92910 ? 43  ILE A CG1 1 
ATOM   341  C  CG2 . ILE A 1 45  ? 37.93228 -29.01779 -16.91359 1.000 16.39784 ? 43  ILE A CG2 1 
ATOM   342  C  CD1 . ILE A 1 45  ? 38.46400 -32.24655 -16.78580 1.000 17.34820 ? 43  ILE A CD1 1 
ATOM   343  N  N   . ASN A 1 46  ? 33.95725 -30.90530 -17.76282 1.000 12.78337 ? 44  ASN A N   1 
ATOM   344  C  CA  . ASN A 1 46  ? 33.19442 -32.11956 -18.03184 1.000 15.38501 ? 44  ASN A CA  1 
ATOM   345  C  C   . ASN A 1 46  ? 34.13876 -33.27576 -18.36909 1.000 15.03742 ? 44  ASN A C   1 
ATOM   346  O  O   . ASN A 1 46  ? 35.24483 -33.08056 -18.88233 1.000 15.22173 ? 44  ASN A O   1 
ATOM   347  C  CB  . ASN A 1 46  ? 32.11435 -31.89885 -19.10653 1.000 14.80100 ? 44  ASN A CB  1 
ATOM   348  C  CG  . ASN A 1 46  ? 32.60687 -31.20494 -20.38324 1.000 18.78201 ? 44  ASN A CG  1 
ATOM   349  O  OD1 . ASN A 1 46  ? 33.63067 -30.51855 -20.41629 1.000 15.18836 ? 44  ASN A OD1 1 
ATOM   350  N  ND2 . ASN A 1 46  ? 31.78628 -31.30709 -21.42174 1.000 17.19857 ? 44  ASN A ND2 1 
ATOM   351  N  N   . ILE A 1 47  ? 33.72096 -34.48646 -17.99402 1.000 12.95157 ? 45  ILE A N   1 
ATOM   352  C  CA  . ILE A 1 47  ? 34.55484 -35.68751 -18.05999 1.000 13.85413 ? 45  ILE A CA  1 
ATOM   353  C  C   . ILE A 1 47  ? 33.68499 -36.81348 -18.59535 1.000 15.36130 ? 45  ILE A C   1 
ATOM   354  O  O   . ILE A 1 47  ? 32.82209 -37.33057 -17.87960 1.000 14.21095 ? 45  ILE A O   1 
ATOM   355  C  CB  . ILE A 1 47  ? 35.13262 -36.06327 -16.68165 1.000 16.52066 ? 45  ILE A CB  1 
ATOM   356  C  CG1 . ILE A 1 47  ? 35.98428 -34.90835 -16.10910 1.000 15.26830 ? 45  ILE A CG1 1 
ATOM   357  C  CG2 . ILE A 1 47  ? 35.95377 -37.36850 -16.79191 1.000 17.20671 ? 45  ILE A CG2 1 
ATOM   358  C  CD1 . ILE A 1 47  ? 36.49813 -35.15471 -14.67096 1.000 14.37236 ? 45  ILE A CD1 1 
ATOM   359  N  N   . GLU A 1 48  ? 33.88503 -37.19101 -19.85366 1.000 14.94205 ? 46  GLU A N   1 
ATOM   360  C  CA  . GLU A 1 48  ? 32.98915 -38.14690 -20.48726 1.000 14.69680 ? 46  GLU A CA  1 
ATOM   361  C  C   . GLU A 1 48  ? 33.45916 -39.57496 -20.26542 1.000 14.71750 ? 46  GLU A C   1 
ATOM   362  O  O   . GLU A 1 48  ? 34.54968 -39.83790 -19.74675 1.000 14.71841 ? 46  GLU A O   1 
ATOM   363  C  CB  . GLU A 1 48  ? 32.84774 -37.82330 -21.97945 1.000 14.77147 ? 46  GLU A CB  1 
ATOM   364  C  CG  . GLU A 1 48  ? 32.29311 -36.40400 -22.18486 1.000 13.96517 ? 46  GLU A CG  1 
ATOM   365  C  CD  . GLU A 1 48  ? 31.98359 -36.02004 -23.61472 1.000 17.97970 ? 46  GLU A CD  1 
ATOM   366  O  OE1 . GLU A 1 48  ? 32.62396 -36.56150 -24.55556 1.000 16.74836 ? 46  GLU A OE1 1 
ATOM   367  O  OE2 . GLU A 1 48  ? 31.15483 -35.08709 -23.77741 1.000 17.25674 ? 46  GLU A OE2 1 
ATOM   368  N  N   . ASN A 1 49  ? 32.58621 -40.50521 -20.64420 1.000 15.21888 ? 47  ASN A N   1 
ATOM   369  C  CA  . ASN A 1 49  ? 32.81996 -41.93561 -20.52972 1.000 15.08781 ? 47  ASN A CA  1 
ATOM   370  C  C   . ASN A 1 49  ? 32.31708 -42.58210 -21.80518 1.000 15.51322 ? 47  ASN A C   1 
ATOM   371  O  O   . ASN A 1 49  ? 31.35066 -42.11330 -22.40502 1.000 15.90069 ? 47  ASN A O   1 
ATOM   372  C  CB  . ASN A 1 49  ? 32.09438 -42.52898 -19.31179 1.000 14.43959 ? 47  ASN A CB  1 
ATOM   373  C  CG  . ASN A 1 49  ? 32.53934 -43.94593 -18.99870 1.000 17.66884 ? 47  ASN A CG  1 
ATOM   374  O  OD1 . ASN A 1 49  ? 32.02080 -44.90454 -19.57833 1.000 17.82493 ? 47  ASN A OD1 1 
ATOM   375  N  ND2 . ASN A 1 49  ? 33.51028 -44.08708 -18.08712 1.000 17.26353 ? 47  ASN A ND2 1 
ATOM   376  N  N   . ALA A 1 50  ? 32.97654 -43.67084 -22.21024 1.000 15.49118 ? 48  ALA A N   1 
ATOM   377  C  CA  . ALA A 1 50  ? 32.53598 -44.39069 -23.40221 1.000 19.32514 ? 48  ALA A CA  1 
ATOM   378  C  C   . ALA A 1 50  ? 31.06806 -44.80061 -23.30142 1.000 15.60530 ? 48  ALA A C   1 
ATOM   379  O  O   . ALA A 1 50  ? 30.34427 -44.80096 -24.30821 1.000 17.07011 ? 48  ALA A O   1 
ATOM   380  C  CB  . ALA A 1 50  ? 33.43047 -45.61669 -23.61134 1.000 18.71565 ? 48  ALA A CB  1 
ATOM   381  N  N   . SER A 1 51  ? 30.61337 -45.13516 -22.10250 1.000 15.16680 ? 49  SER A N   1 
ATOM   382  C  CA  . SER A 1 51  ? 29.19016 -45.28874 -21.82386 1.000 16.20806 ? 49  SER A CA  1 
ATOM   383  C  C   . SER A 1 51  ? 28.67301 -43.90425 -21.43232 1.000 16.58499 ? 49  SER A C   1 
ATOM   384  O  O   . SER A 1 51  ? 28.99033 -43.40576 -20.34577 1.000 15.87030 ? 49  SER A O   1 
ATOM   385  C  CB  . SER A 1 51  ? 28.97412 -46.30387 -20.70521 1.000 17.38121 ? 49  SER A CB  1 
ATOM   386  O  OG  . SER A 1 51  ? 27.58444 -46.44533 -20.44966 1.000 18.02381 ? 49  SER A OG  1 
ATOM   387  N  N   . PHE A 1 52  ? 27.89917 -43.27820 -22.32461 1.000 15.59136 ? 50  PHE A N   1 
ATOM   388  C  CA  . PHE A 1 52  ? 27.65240 -41.83337 -22.22456 1.000 15.74151 ? 50  PHE A CA  1 
ATOM   389  C  C   . PHE A 1 52  ? 27.05249 -41.43999 -20.88413 1.000 15.37053 ? 50  PHE A C   1 
ATOM   390  O  O   . PHE A 1 52  ? 27.34432 -40.35337 -20.36324 1.000 13.97415 ? 50  PHE A O   1 
ATOM   391  C  CB  . PHE A 1 52  ? 26.71844 -41.37703 -23.34154 1.000 15.15911 ? 50  PHE A CB  1 
ATOM   392  C  CG  . PHE A 1 52  ? 27.39292 -41.17328 -24.66844 1.000 17.28093 ? 50  PHE A CG  1 
ATOM   393  C  CD1 . PHE A 1 52  ? 28.71520 -41.56723 -24.88066 1.000 18.85952 ? 50  PHE A CD1 1 
ATOM   394  C  CD2 . PHE A 1 52  ? 26.68611 -40.60074 -25.71711 1.000 17.07243 ? 50  PHE A CD2 1 
ATOM   395  C  CE1 . PHE A 1 52  ? 29.31610 -41.38118 -26.12129 1.000 19.48653 ? 50  PHE A CE1 1 
ATOM   396  C  CE2 . PHE A 1 52  ? 27.28341 -40.41924 -26.95610 1.000 18.06614 ? 50  PHE A CE2 1 
ATOM   397  C  CZ  . PHE A 1 52  ? 28.59439 -40.79309 -27.15080 1.000 15.91412 ? 50  PHE A CZ  1 
ATOM   398  N  N   . GLY A 1 53  ? 26.18143 -42.29316 -20.32783 1.000 14.92392 ? 51  GLY A N   1 
ATOM   399  C  CA  . GLY A 1 53  ? 25.47426 -41.96197 -19.10107 1.000 17.07083 ? 51  GLY A CA  1 
ATOM   400  C  C   . GLY A 1 53  ? 26.36871 -41.77626 -17.89017 1.000 17.27775 ? 51  GLY A C   1 
ATOM   401  O  O   . GLY A 1 53  ? 25.92461 -41.20994 -16.88964 1.000 18.76238 ? 51  GLY A O   1 
ATOM   402  N  N   . LEU A 1 54  ? 27.61667 -42.23108 -17.94824 1.000 13.47440 ? 52  LEU A N   1 
ATOM   403  C  CA  . LEU A 1 54  ? 28.53342 -42.02422 -16.83578 1.000 14.34240 ? 52  LEU A CA  1 
ATOM   404  C  C   . LEU A 1 54  ? 29.34676 -40.73467 -16.97132 1.000 13.89773 ? 52  LEU A C   1 
ATOM   405  O  O   . LEU A 1 54  ? 30.20203 -40.45991 -16.12601 1.000 14.74798 ? 52  LEU A O   1 
ATOM   406  C  CB  . LEU A 1 54  ? 29.46775 -43.23750 -16.69220 1.000 15.28673 ? 52  LEU A CB  1 
ATOM   407  C  CG  . LEU A 1 54  ? 28.69367 -44.50911 -16.33701 1.000 18.88095 ? 52  LEU A CG  1 
ATOM   408  C  CD1 . LEU A 1 54  ? 29.61359 -45.69766 -16.21606 1.000 18.84867 ? 52  LEU A CD1 1 
ATOM   409  C  CD2 . LEU A 1 54  ? 27.92611 -44.30400 -15.02139 1.000 20.50515 ? 52  LEU A CD2 1 
ATOM   410  N  N   . THR A 1 55  ? 29.08232 -39.94649 -18.00399 1.000 13.34426 ? 53  THR A N   1 
ATOM   411  C  CA  . THR A 1 55  ? 29.68241 -38.62779 -18.14249 1.000 13.02081 ? 53  THR A CA  1 
ATOM   412  C  C   . THR A 1 55  ? 29.32190 -37.75812 -16.94937 1.000 15.14198 ? 53  THR A C   1 
ATOM   413  O  O   . THR A 1 55  ? 28.18423 -37.78423 -16.46430 1.000 14.30445 ? 53  THR A O   1 
ATOM   414  C  CB  . THR A 1 55  ? 29.17516 -37.97212 -19.43065 1.000 14.71280 ? 53  THR A CB  1 
ATOM   415  O  OG1 . THR A 1 55  ? 29.65960 -38.71343 -20.55164 1.000 14.73153 ? 53  THR A OG1 1 
ATOM   416  C  CG2 . THR A 1 55  ? 29.57530 -36.46556 -19.53144 1.000 12.68231 ? 53  THR A CG2 1 
ATOM   417  N  N   . ASN A 1 56  ? 30.28862 -36.97037 -16.49579 1.000 12.63174 ? 54  ASN A N   1 
ATOM   418  C  CA  . ASN A 1 56  ? 30.06985 -35.97131 -15.45493 1.000 11.23360 ? 54  ASN A CA  1 
ATOM   419  C  C   . ASN A 1 56  ? 30.27166 -34.55848 -15.99350 1.000 14.11885 ? 54  ASN A C   1 
ATOM   420  O  O   . ASN A 1 56  ? 31.29299 -34.26914 -16.62269 1.000 16.49295 ? 54  ASN A O   1 
ATOM   421  C  CB  . ASN A 1 56  ? 31.01979 -36.19483 -14.28358 1.000 13.23200 ? 54  ASN A CB  1 
ATOM   422  C  CG  . ASN A 1 56  ? 30.49281 -35.59129 -13.01628 1.000 18.26892 ? 54  ASN A CG  1 
ATOM   423  O  OD1 . ASN A 1 56  ? 29.36692 -35.87266 -12.60800 1.000 16.09721 ? 54  ASN A OD1 1 
ATOM   424  N  ND2 . ASN A 1 56  ? 31.26192 -34.66880 -12.44225 1.000 14.45036 ? 54  ASN A ND2 1 
ATOM   425  N  N   . CYS A 1 57  ? 29.30892 -33.67870 -15.71050 1.000 12.42666 ? 55  CYS A N   1 
ATOM   426  C  CA  . CYS A 1 57  ? 29.34941 -32.28156 -16.13957 1.000 13.14995 ? 55  CYS A CA  1 
ATOM   427  C  C   . CYS A 1 57  ? 30.39222 -31.45754 -15.39258 0.896 13.42812 ? 55  CYS A C   1 
ATOM   428  O  O   . CYS A 1 57  ? 30.77277 -31.75887 -14.25917 1.000 14.47814 ? 55  CYS A O   1 
ATOM   429  C  CB  . CYS A 1 57  ? 27.99302 -31.62323 -15.90810 1.000 17.69895 ? 55  CYS A CB  1 
ATOM   430  S  SG  . CYS A 1 57  ? 26.67700 -32.29911 -16.90425 1.000 15.75880 ? 55  CYS A SG  1 
ATOM   431  N  N   . ALA A 1 58  ? 30.78218 -30.33892 -16.02394 1.000 13.86032 ? 56  ALA A N   1 
ATOM   432  C  CA  . ALA A 1 58  ? 31.75501 -29.43297 -15.41516 1.000 13.45172 ? 56  ALA A CA  1 
ATOM   433  C  C   . ALA A 1 58  ? 31.25500 -28.87282 -14.08864 1.000 15.31511 ? 56  ALA A C   1 
ATOM   434  O  O   . ALA A 1 58  ? 32.02007 -28.77762 -13.12117 1.000 14.20755 ? 56  ALA A O   1 
ATOM   435  C  CB  . ALA A 1 58  ? 32.08137 -28.29986 -16.38154 1.000 15.10844 ? 56  ALA A CB  1 
ATOM   436  N  N   . GLU A 1 59  ? 29.97642 -28.48766 -14.02647 1.000 15.55457 ? 57  GLU A N   1 
ATOM   437  C  CA  . GLU A 1 59  ? 29.44222 -27.92332 -12.78580 1.000 13.86648 ? 57  GLU A CA  1 
ATOM   438  C  C   . GLU A 1 59  ? 29.54742 -28.92708 -11.64483 1.000 15.19747 ? 57  GLU A C   1 
ATOM   439  O  O   . GLU A 1 59  ? 30.03074 -28.60687 -10.54775 1.000 14.88377 ? 57  GLU A O   1 
ATOM   440  C  CB  . GLU A 1 59  ? 27.98867 -27.50209 -13.00149 1.000 12.92666 ? 57  GLU A CB  1 
ATOM   441  C  CG  . GLU A 1 59  ? 27.78642 -26.49253 -14.13981 1.000 14.92077 ? 57  GLU A CG  1 
ATOM   442  C  CD  . GLU A 1 59  ? 27.54124 -27.14180 -15.48684 1.000 18.26886 ? 57  GLU A CD  1 
ATOM   443  O  OE1 . GLU A 1 59  ? 28.30133 -28.04441 -15.87498 1.000 17.33885 ? 57  GLU A OE1 1 
ATOM   444  O  OE2 . GLU A 1 59  ? 26.55670 -26.76068 -16.14904 1.000 19.88151 ? 57  GLU A OE2 1 
ATOM   445  N  N   . ARG A 1 60  ? 29.13279 -30.16726 -11.89995 1.000 13.89372 ? 58  ARG A N   1 
ATOM   446  C  CA  . ARG A 1 60  ? 29.20595 -31.18330 -10.86519 1.000 12.76570 ? 58  ARG A CA  1 
ATOM   447  C  C   . ARG A 1 60  ? 30.63974 -31.52651 -10.50983 1.000 15.58371 ? 58  ARG A C   1 
ATOM   448  O  O   . ARG A 1 60  ? 30.93714 -31.75651 -9.33493  1.000 15.17933 ? 58  ARG A O   1 
ATOM   449  C  CB  . ARG A 1 60  ? 28.41998 -32.42894 -11.28851 1.000 11.12823 ? 58  ARG A CB  1 
ATOM   450  C  CG  . ARG A 1 60  ? 26.91390 -32.13008 -11.23929 1.000 14.12991 ? 58  ARG A CG  1 
ATOM   451  C  CD  . ARG A 1 60  ? 26.08049 -33.33729 -11.60663 1.000 16.00113 ? 58  ARG A CD  1 
ATOM   452  N  NE  . ARG A 1 60  ? 26.01216 -33.53303 -13.05586 1.000 17.13621 ? 58  ARG A NE  1 
ATOM   453  C  CZ  . ARG A 1 60  ? 25.72626 -34.69666 -13.62642 1.000 20.47138 ? 58  ARG A CZ  1 
ATOM   454  N  NH1 . ARG A 1 60  ? 25.47093 -35.77863 -12.90117 1.000 18.43089 ? 58  ARG A NH1 1 
ATOM   455  N  NH2 . ARG A 1 60  ? 25.66986 -34.77404 -14.95550 1.000 19.89933 ? 58  ARG A NH2 1 
ATOM   456  N  N   . THR A 1 61  ? 31.55049 -31.57476 -11.49930 1.000 13.91160 ? 59  THR A N   1 
ATOM   457  C  CA  . THR A 1 61  ? 32.95575 -31.79313 -11.15614 1.000 14.89285 ? 59  THR A CA  1 
ATOM   458  C  C   . THR A 1 61  ? 33.44159 -30.74935 -10.15064 1.000 14.03244 ? 59  THR A C   1 
ATOM   459  O  O   . THR A 1 61  ? 34.10995 -31.09062 -9.16566  1.000 14.83348 ? 59  THR A O   1 
ATOM   460  C  CB  . THR A 1 61  ? 33.81980 -31.77588 -12.41464 1.000 14.22882 ? 59  THR A CB  1 
ATOM   461  O  OG1 . THR A 1 61  ? 33.45713 -32.91763 -13.22586 1.000 14.01310 ? 59  THR A OG1 1 
ATOM   462  C  CG2 . THR A 1 61  ? 35.31049 -31.83721 -12.04702 1.000 15.48754 ? 59  THR A CG2 1 
ATOM   463  N  N   . ALA A 1 62  ? 33.08586 -29.47735 -10.36255 1.000 14.17589 ? 60  ALA A N   1 
ATOM   464  C  CA  . ALA A 1 62  ? 33.52952 -28.43712 -9.43277  1.000 14.23287 ? 60  ALA A CA  1 
ATOM   465  C  C   . ALA A 1 62  ? 32.94544 -28.65520 -8.03860  1.000 15.15564 ? 60  ALA A C   1 
ATOM   466  O  O   . ALA A 1 62  ? 33.66319 -28.53458 -7.03747  1.000 15.62439 ? 60  ALA A O   1 
ATOM   467  C  CB  . ALA A 1 62  ? 33.14834 -27.05736 -9.97108  1.000 15.51929 ? 60  ALA A CB  1 
ATOM   468  N  N   . PHE A 1 63  ? 31.64867 -28.98406 -7.95415  1.000 14.61827 ? 61  PHE A N   1 
ATOM   469  C  CA  . PHE A 1 63  ? 31.03864 -29.24713 -6.64964  1.000 15.25336 ? 61  PHE A CA  1 
ATOM   470  C  C   . PHE A 1 63  ? 31.67467 -30.45443 -5.98343  1.000 17.41912 ? 61  PHE A C   1 
ATOM   471  O  O   . PHE A 1 63  ? 31.91396 -30.44529 -4.77182  1.000 15.61271 ? 61  PHE A O   1 
ATOM   472  C  CB  . PHE A 1 63  ? 29.51983 -29.44795 -6.77527  1.000 15.41139 ? 61  PHE A CB  1 
ATOM   473  C  CG  . PHE A 1 63  ? 28.75186 -28.15964 -6.77951  1.000 14.54015 ? 61  PHE A CG  1 
ATOM   474  C  CD1 . PHE A 1 63  ? 28.50690 -27.47826 -5.58776  1.000 16.27597 ? 61  PHE A CD1 1 
ATOM   475  C  CD2 . PHE A 1 63  ? 28.34575 -27.58672 -7.97863  1.000 16.36088 ? 61  PHE A CD2 1 
ATOM   476  C  CE1 . PHE A 1 63  ? 27.83849 -26.25589 -5.58273  1.000 16.46199 ? 61  PHE A CE1 1 
ATOM   477  C  CE2 . PHE A 1 63  ? 27.66234 -26.35800 -7.98791  1.000 17.61086 ? 61  PHE A CE2 1 
ATOM   478  C  CZ  . PHE A 1 63  ? 27.40236 -25.70476 -6.78807  1.000 17.71779 ? 61  PHE A CZ  1 
ATOM   479  N  N   . PHE A 1 64  ? 31.93465 -31.51810 -6.74390  1.000 13.20703 ? 62  PHE A N   1 
ATOM   480  C  CA  . PHE A 1 64  ? 32.48709 -32.70318 -6.10450  1.000 14.55962 ? 62  PHE A CA  1 
ATOM   481  C  C   . PHE A 1 64  ? 33.89713 -32.43087 -5.59309  1.000 14.23850 ? 62  PHE A C   1 
ATOM   482  O  O   . PHE A 1 64  ? 34.25994 -32.87610 -4.49804  1.000 16.34379 ? 62  PHE A O   1 
ATOM   483  C  CB  . PHE A 1 64  ? 32.45737 -33.89241 -7.06834  1.000 13.01516 ? 62  PHE A CB  1 
ATOM   484  C  CG  . PHE A 1 64  ? 31.06694 -34.30138 -7.49031  1.000 13.64329 ? 62  PHE A CG  1 
ATOM   485  C  CD1 . PHE A 1 64  ? 29.95865 -33.97891 -6.72328  1.000 15.22076 ? 62  PHE A CD1 1 
ATOM   486  C  CD2 . PHE A 1 64  ? 30.87142 -34.98148 -8.68953  1.000 15.48128 ? 62  PHE A CD2 1 
ATOM   487  C  CE1 . PHE A 1 64  ? 28.67135 -34.35498 -7.12740  1.000 17.10400 ? 62  PHE A CE1 1 
ATOM   488  C  CE2 . PHE A 1 64  ? 29.59369 -35.35835 -9.10480  1.000 18.01198 ? 62  PHE A CE2 1 
ATOM   489  C  CZ  . PHE A 1 64  ? 28.49205 -35.04422 -8.32880  1.000 17.88137 ? 62  PHE A CZ  1 
ATOM   490  N  N   . LYS A 1 65  ? 34.69051 -31.67081 -6.35278  1.000 14.11493 ? 63  LYS A N   1 
ATOM   491  C  CA  . LYS A 1 65  ? 35.99618 -31.25114 -5.85723  1.000 15.26925 ? 63  LYS A CA  1 
ATOM   492  C  C   . LYS A 1 65  ? 35.85119 -30.47035 -4.55606  1.000 16.46394 ? 63  LYS A C   1 
ATOM   493  O  O   . LYS A 1 65  ? 36.45877 -30.82268 -3.53453  1.000 15.42783 ? 63  LYS A O   1 
ATOM   494  C  CB  . LYS A 1 65  ? 36.71448 -30.41848 -6.91271  1.000 16.33183 ? 63  LYS A CB  1 
ATOM   495  C  CG  . LYS A 1 65  ? 37.15614 -31.23187 -8.11636  1.000 17.28791 ? 63  LYS A CG  1 
ATOM   496  C  CD  . LYS A 1 65  ? 37.71761 -30.31962 -9.21118  1.000 15.77752 ? 63  LYS A CD  1 
ATOM   497  C  CE  . LYS A 1 65  ? 39.03946 -29.67618 -8.78674  1.000 19.12206 ? 63  LYS A CE  1 
ATOM   498  N  NZ  . LYS A 1 65  ? 39.69846 -29.03348 -9.96576  1.000 20.76626 ? 63  LYS A NZ  1 
ATOM   499  N  N   . ALA A 1 66  ? 35.00625 -29.43263 -4.56732  1.000 15.23024 ? 64  ALA A N   1 
ATOM   500  C  CA  . ALA A 1 66  ? 34.86063 -28.56546 -3.39447  1.000 16.45733 ? 64  ALA A CA  1 
ATOM   501  C  C   . ALA A 1 66  ? 34.33137 -29.33717 -2.19383  1.000 16.82840 ? 64  ALA A C   1 
ATOM   502  O  O   . ALA A 1 66  ? 34.87611 -29.23315 -1.08409  1.000 17.65043 ? 64  ALA A O   1 
ATOM   503  C  CB  . ALA A 1 66  ? 33.92119 -27.39918 -3.70666  1.000 15.84177 ? 64  ALA A CB  1 
ATOM   504  N  N   . VAL A 1 67  ? 33.24352 -30.08936 -2.38853  1.000 14.64926 ? 65  VAL A N   1 
ATOM   505  C  CA  . VAL A 1 67  ? 32.61720 -30.76872 -1.25587  1.000 15.69359 ? 65  VAL A CA  1 
ATOM   506  C  C   . VAL A 1 67  ? 33.57331 -31.80586 -0.67693  1.000 14.82888 ? 65  VAL A C   1 
ATOM   507  O  O   . VAL A 1 67  ? 33.60890 -32.01854 0.54237   1.000 16.85862 ? 65  VAL A O   1 
ATOM   508  C  CB  . VAL A 1 67  ? 31.26111 -31.37235 -1.68296  1.000 18.64544 ? 65  VAL A CB  1 
ATOM   509  C  CG1 . VAL A 1 67  ? 30.72027 -32.36506 -0.63368  1.000 16.32185 ? 65  VAL A CG1 1 
ATOM   510  C  CG2 . VAL A 1 67  ? 30.25127 -30.24049 -1.96860  1.000 17.23531 ? 65  VAL A CG2 1 
ATOM   511  N  N   . SER A 1 68  ? 34.40540 -32.41876 -1.52071  1.000 15.48473 ? 66  SER A N   1 
ATOM   512  C  CA  . SER A 1 68  ? 35.38542 -33.38994 -1.02669  1.000 18.39589 ? 66  SER A CA  1 
ATOM   513  C  C   . SER A 1 68  ? 36.44271 -32.75159 -0.13913  1.000 20.11239 ? 66  SER A C   1 
ATOM   514  O  O   . SER A 1 68  ? 37.07737 -33.46109 0.65372   1.000 19.50268 ? 66  SER A O   1 
ATOM   515  C  CB  . SER A 1 68  ? 36.07966 -34.10586 -2.18801  1.000 18.15493 ? 66  SER A CB  1 
ATOM   516  O  OG  . SER A 1 68  ? 37.13163 -33.31910 -2.74242  1.000 18.82532 ? 66  SER A OG  1 
ATOM   517  N  N   . GLU A 1 69  ? 36.67340 -31.44904 -0.27465  1.000 18.10255 ? 67  GLU A N   1 
ATOM   518  C  CA  . GLU A 1 69  ? 37.62223 -30.74908 0.58344   1.000 20.25500 ? 67  GLU A CA  1 
ATOM   519  C  C   . GLU A 1 69  ? 36.94317 -30.15607 1.81482   1.000 23.64122 ? 67  GLU A C   1 
ATOM   520  O  O   . GLU A 1 69  ? 37.56404 -29.36903 2.53673   1.000 26.45668 ? 67  GLU A O   1 
ATOM   521  C  CB  . GLU A 1 69  ? 38.33978 -29.62955 -0.19186  1.000 19.63078 ? 67  GLU A CB  1 
ATOM   522  C  CG  . GLU A 1 69  ? 39.06954 -29.97429 -1.52288  1.000 24.88294 ? 67  GLU A CG  1 
ATOM   523  C  CD  . GLU A 1 69  ? 40.12064 -31.07566 -1.42546  1.000 27.46734 ? 67  GLU A CD  1 
ATOM   524  O  OE1 . GLU A 1 69  ? 40.69319 -31.27769 -0.32792  1.000 28.28600 ? 67  GLU A OE1 1 
ATOM   525  O  OE2 . GLU A 1 69  ? 40.43521 -31.69524 -2.47274  1.000 25.89645 ? 67  GLU A OE2 1 
ATOM   526  N  N   . GLY A 1 70  ? 35.68425 -30.50197 2.06946   1.000 18.90487 ? 68  GLY A N   1 
ATOM   527  C  CA  . GLY A 1 70  ? 34.97454 -29.97647 3.21698   1.000 18.65965 ? 68  GLY A CA  1 
ATOM   528  C  C   . GLY A 1 70  ? 34.18544 -28.70268 2.98557   1.000 20.63509 ? 68  GLY A C   1 
ATOM   529  O  O   . GLY A 1 70  ? 33.59885 -28.17019 3.94265   1.000 20.31832 ? 68  GLY A O   1 
ATOM   530  N  N   . GLU A 1 71  ? 34.15413 -28.18183 1.76126   1.000 20.15202 ? 69  GLU A N   1 
ATOM   531  C  CA  . GLU A 1 71  ? 33.46316 -26.92389 1.50056   1.000 18.27169 ? 69  GLU A CA  1 
ATOM   532  C  C   . GLU A 1 71  ? 31.95375 -27.11651 1.57126   1.000 19.89289 ? 69  GLU A C   1 
ATOM   533  O  O   . GLU A 1 71  ? 31.40928 -28.04021 0.95905   1.000 18.78456 ? 69  GLU A O   1 
ATOM   534  C  CB  . GLU A 1 71  ? 33.83226 -26.38920 0.11494   1.000 16.08074 ? 69  GLU A CB  1 
ATOM   535  C  CG  . GLU A 1 71  ? 35.32179 -26.27189 -0.17845  1.000 17.94013 ? 69  GLU A CG  1 
ATOM   536  C  CD  . GLU A 1 71  ? 36.02186 -25.18575 0.62131   1.000 25.77774 ? 69  GLU A CD  1 
ATOM   537  O  OE1 . GLU A 1 71  ? 35.34813 -24.51115 1.43935   1.000 24.80610 ? 69  GLU A OE1 1 
ATOM   538  O  OE2 . GLU A 1 71  ? 37.24914 -25.01059 0.41234   1.000 23.00070 ? 69  GLU A OE2 1 
ATOM   539  N  N   . ARG A 1 72  ? 31.26565 -26.21169 2.27430   1.000 16.89444 ? 70  ARG A N   1 
ATOM   540  C  CA  . ARG A 1 72  ? 29.81318 -26.24921 2.33121   1.000 16.75600 ? 70  ARG A CA  1 
ATOM   541  C  C   . ARG A 1 72  ? 29.16788 -24.88993 2.12355   1.000 19.76437 ? 70  ARG A C   1 
ATOM   542  O  O   . ARG A 1 72  ? 27.93405 -24.80087 2.15753   1.000 22.76460 ? 70  ARG A O   1 
ATOM   543  C  CB  . ARG A 1 72  ? 29.33660 -26.82545 3.67596   1.000 22.07776 ? 70  ARG A CB  1 
ATOM   544  C  CG  . ARG A 1 72  ? 29.81235 -28.24472 3.96822   1.000 19.87762 ? 70  ARG A CG  1 
ATOM   545  C  CD  . ARG A 1 72  ? 29.17719 -29.28021 3.04174   1.000 21.07475 ? 70  ARG A CD  1 
ATOM   546  N  NE  . ARG A 1 72  ? 29.57438 -30.63584 3.41908   1.000 22.65868 ? 70  ARG A NE  1 
ATOM   547  C  CZ  . ARG A 1 72  ? 30.70664 -31.22542 3.05768   1.000 20.50325 ? 70  ARG A CZ  1 
ATOM   548  N  NH1 . ARG A 1 72  ? 31.60890 -30.60361 2.30720   1.000 18.25317 ? 70  ARG A NH1 1 
ATOM   549  N  NH2 . ARG A 1 72  ? 30.94732 -32.47177 3.46294   1.000 24.11563 ? 70  ARG A NH2 1 
ATOM   550  N  N   . SER A 1 73  ? 29.95223 -23.83271 1.90876   1.000 19.79945 ? 71  SER A N   1 
ATOM   551  C  CA  . SER A 1 73  ? 29.41790 -22.47417 1.79157   1.000 19.78191 ? 71  SER A CA  1 
ATOM   552  C  C   . SER A 1 73  ? 29.92271 -21.85849 0.49583   1.000 17.43493 ? 71  SER A C   1 
ATOM   553  O  O   . SER A 1 73  ? 31.10314 -21.51663 0.38685   1.000 20.20824 ? 71  SER A O   1 
ATOM   554  C  CB  . SER A 1 73  ? 29.82296 -21.61723 2.99183   1.000 24.43096 ? 71  SER A CB  1 
ATOM   555  O  OG  . SER A 1 73  ? 29.35838 -22.20526 4.19285   1.000 26.82452 ? 71  SER A OG  1 
ATOM   556  N  N   . PHE A 1 74  ? 29.02705 -21.71934 -0.47437  1.000 18.33916 ? 72  PHE A N   1 
ATOM   557  C  CA  . PHE A 1 74  ? 29.37493 -21.26681 -1.80948  1.000 18.00572 ? 72  PHE A CA  1 
ATOM   558  C  C   . PHE A 1 74  ? 28.74541 -19.90722 -2.06870  1.000 18.29655 ? 72  PHE A C   1 
ATOM   559  O  O   . PHE A 1 74  ? 27.61891 -19.64702 -1.63637  1.000 21.53443 ? 72  PHE A O   1 
ATOM   560  C  CB  . PHE A 1 74  ? 28.90959 -22.30065 -2.82709  1.000 18.76400 ? 72  PHE A CB  1 
ATOM   561  C  CG  . PHE A 1 74  ? 29.49925 -23.64275 -2.56921  1.000 16.78231 ? 72  PHE A CG  1 
ATOM   562  C  CD1 . PHE A 1 74  ? 30.83855 -23.86114 -2.84711  1.000 17.03739 ? 72  PHE A CD1 1 
ATOM   563  C  CD2 . PHE A 1 74  ? 28.75199 -24.65908 -1.99305  1.000 16.41480 ? 72  PHE A CD2 1 
ATOM   564  C  CE1 . PHE A 1 74  ? 31.43125 -25.09295 -2.58544  1.000 17.38254 ? 72  PHE A CE1 1 
ATOM   565  C  CE2 . PHE A 1 74  ? 29.33542 -25.90530 -1.73474  1.000 17.19591 ? 72  PHE A CE2 1 
ATOM   566  C  CZ  . PHE A 1 74  ? 30.67447 -26.11230 -2.03547  1.000 17.44880 ? 72  PHE A CZ  1 
ATOM   567  N  N   . THR A 1 75  ? 29.48194 -19.04128 -2.75807  1.000 18.16811 ? 73  THR A N   1 
ATOM   568  C  CA  . THR A 1 75  ? 29.01269 -17.68344 -2.98819  1.000 20.90252 ? 73  THR A CA  1 
ATOM   569  C  C   . THR A 1 75  ? 28.81652 -17.33610 -4.45113  1.000 21.71778 ? 73  THR A C   1 
ATOM   570  O  O   . THR A 1 75  ? 28.13143 -16.34757 -4.72954  1.000 19.16252 ? 73  THR A O   1 
ATOM   571  C  CB  . THR A 1 75  ? 29.96527 -16.63785 -2.37118  1.000 25.22126 ? 73  THR A CB  1 
ATOM   572  O  OG1 . THR A 1 75  ? 31.26827 -16.73545 -2.95820  1.000 29.85920 ? 73  THR A OG1 1 
ATOM   573  C  CG2 . THR A 1 75  ? 30.06919 -16.85334 -0.87521  1.000 29.04224 ? 73  THR A CG2 1 
ATOM   574  N  N   . HIS A 1 76  ? 29.37626 -18.10841 -5.38592  1.000 17.75020 ? 74  HIS A N   1 
ATOM   575  C  CA  . HIS A 1 76  ? 29.18171 -17.82418 -6.80497  1.000 18.25511 ? 74  HIS A CA  1 
ATOM   576  C  C   . HIS A 1 76  ? 29.51645 -19.06674 -7.62028  1.000 17.47388 ? 74  HIS A C   1 
ATOM   577  O  O   . HIS A 1 76  ? 30.37941 -19.85492 -7.23635  1.000 18.13552 ? 74  HIS A O   1 
ATOM   578  C  CB  . HIS A 1 76  ? 30.07293 -16.65852 -7.26668  1.000 17.86380 ? 74  HIS A CB  1 
ATOM   579  C  CG  . HIS A 1 76  ? 29.50728 -15.87798 -8.41226  1.000 19.90088 ? 74  HIS A CG  1 
ATOM   580  N  ND1 . HIS A 1 76  ? 28.93493 -14.63461 -8.24779  1.000 21.32071 ? 74  HIS A ND1 1 
ATOM   581  C  CD2 . HIS A 1 76  ? 29.44073 -16.15218 -9.73728  1.000 18.83146 ? 74  HIS A CD2 1 
ATOM   582  C  CE1 . HIS A 1 76  ? 28.51887 -14.18533 -9.42041  1.000 25.46990 ? 74  HIS A CE1 1 
ATOM   583  N  NE2 . HIS A 1 76  ? 28.81332 -15.08623 -10.34012 1.000 20.65079 ? 74  HIS A NE2 1 
ATOM   584  N  N   . LEU A 1 77  ? 28.84673 -19.21899 -8.76013  1.000 16.36033 ? 75  LEU A N   1 
ATOM   585  C  CA  . LEU A 1 77  ? 29.21441 -20.24246 -9.73607  1.000 14.40640 ? 75  LEU A CA  1 
ATOM   586  C  C   . LEU A 1 77  ? 29.23466 -19.60407 -11.11046 1.000 15.01029 ? 75  LEU A C   1 
ATOM   587  O  O   . LEU A 1 77  ? 28.25791 -18.95475 -11.49572 1.000 17.54139 ? 75  LEU A O   1 
ATOM   588  C  CB  . LEU A 1 77  ? 28.22701 -21.41663 -9.73721  1.000 16.69361 ? 75  LEU A CB  1 
ATOM   589  C  CG  . LEU A 1 77  ? 28.42333 -22.45754 -10.85144 1.000 15.45615 ? 75  LEU A CG  1 
ATOM   590  C  CD1 . LEU A 1 77  ? 29.72818 -23.22756 -10.67688 1.000 18.41505 ? 75  LEU A CD1 1 
ATOM   591  C  CD2 . LEU A 1 77  ? 27.19491 -23.39651 -10.89703 1.000 16.53607 ? 75  LEU A CD2 1 
ATOM   592  N  N   . VAL A 1 78  ? 30.33177 -19.79521 -11.83825 1.000 16.53764 ? 76  VAL A N   1 
ATOM   593  C  CA  . VAL A 1 78  ? 30.44544 -19.40605 -13.24098 1.000 17.71830 ? 76  VAL A CA  1 
ATOM   594  C  C   . VAL A 1 78  ? 30.51456 -20.66965 -14.09104 1.000 14.78753 ? 76  VAL A C   1 
ATOM   595  O  O   . VAL A 1 78  ? 31.22875 -21.61651 -13.74382 1.000 15.95398 ? 76  VAL A O   1 
ATOM   596  C  CB  . VAL A 1 78  ? 31.68575 -18.53333 -13.48722 1.000 18.08732 ? 76  VAL A CB  1 
ATOM   597  C  CG1 . VAL A 1 78  ? 31.70152 -18.06770 -14.93435 1.000 17.01330 ? 76  VAL A CG1 1 
ATOM   598  C  CG2 . VAL A 1 78  ? 31.66624 -17.33036 -12.55732 1.000 17.66974 ? 76  VAL A CG2 1 
ATOM   599  N  N   . VAL A 1 79  ? 29.77542 -20.68358 -15.20100 1.000 16.29089 ? 77  VAL A N   1 
ATOM   600  C  CA  . VAL A 1 79  ? 29.80271 -21.79248 -16.15483 1.000 15.84791 ? 77  VAL A CA  1 
ATOM   601  C  C   . VAL A 1 79  ? 30.04826 -21.19882 -17.53454 1.000 16.19032 ? 77  VAL A C   1 
ATOM   602  O  O   . VAL A 1 79  ? 29.40869 -20.20232 -17.89854 1.000 17.65223 ? 77  VAL A O   1 
ATOM   603  C  CB  . VAL A 1 79  ? 28.48678 -22.60100 -16.14744 1.000 16.69347 ? 77  VAL A CB  1 
ATOM   604  C  CG1 . VAL A 1 79  ? 28.64737 -23.93194 -16.92032 1.000 13.42467 ? 77  VAL A CG1 1 
ATOM   605  C  CG2 . VAL A 1 79  ? 28.00409 -22.85970 -14.71677 1.000 15.95756 ? 77  VAL A CG2 1 
ATOM   606  N  N   . ALA A 1 80  ? 30.96265 -21.80394 -18.29503 1.000 15.02116 ? 78  ALA A N   1 
ATOM   607  C  CA  . ALA A 1 80  ? 31.35358 -21.29645 -19.61377 1.000 15.28697 ? 78  ALA A CA  1 
ATOM   608  C  C   . ALA A 1 80  ? 31.27985 -22.38420 -20.67773 1.000 18.76118 ? 78  ALA A C   1 
ATOM   609  O  O   . ALA A 1 80  ? 31.56960 -23.55372 -20.41488 1.000 17.60251 ? 78  ALA A O   1 
ATOM   610  C  CB  . ALA A 1 80  ? 32.78195 -20.73706 -19.60090 1.000 18.23677 ? 78  ALA A CB  1 
ATOM   611  N  N   . GLY A 1 81  ? 30.93114 -21.97620 -21.90484 1.000 17.38184 ? 79  GLY A N   1 
ATOM   612  C  CA  . GLY A 1 81  ? 30.95342 -22.88451 -23.03503 1.000 17.61629 ? 79  GLY A CA  1 
ATOM   613  C  C   . GLY A 1 81  ? 31.34261 -22.13465 -24.29293 1.000 19.34464 ? 79  GLY A C   1 
ATOM   614  O  O   . GLY A 1 81  ? 31.33902 -20.90116 -24.33358 1.000 17.70939 ? 79  GLY A O   1 
ATOM   615  N  N   . HIS A 1 82  ? 31.68750 -22.90614 -25.32720 1.000 19.14335 ? 80  HIS A N   1 
ATOM   616  C  CA  . HIS A 1 82  ? 31.93956 -22.35975 -26.66444 1.000 21.40480 ? 80  HIS A CA  1 
ATOM   617  C  C   . HIS A 1 82  ? 30.61063 -22.29355 -27.41564 1.000 21.06279 ? 80  HIS A C   1 
ATOM   618  O  O   . HIS A 1 82  ? 30.33828 -23.05012 -28.34899 1.000 23.65449 ? 80  HIS A O   1 
ATOM   619  C  CB  . HIS A 1 82  ? 32.96510 -23.20996 -27.41193 1.000 20.19992 ? 80  HIS A CB  1 
ATOM   620  C  CG  . HIS A 1 82  ? 34.38813 -22.96123 -27.00893 1.000 23.16006 ? 80  HIS A CG  1 
ATOM   621  N  ND1 . HIS A 1 82  ? 34.93521 -21.69699 -26.93628 1.000 20.59254 ? 80  HIS A ND1 1 
ATOM   622  C  CD2 . HIS A 1 82  ? 35.38648 -23.82041 -26.68875 1.000 22.44471 ? 80  HIS A CD2 1 
ATOM   623  C  CE1 . HIS A 1 82  ? 36.20482 -21.78772 -26.57335 1.000 25.42315 ? 80  HIS A CE1 1 
ATOM   624  N  NE2 . HIS A 1 82  ? 36.50445 -23.06472 -26.42045 1.000 21.57258 ? 80  HIS A NE2 1 
ATOM   625  N  N   . THR A 1 83  ? 29.75722 -21.38099 -26.95949 1.000 21.82974 ? 81  THR A N   1 
ATOM   626  C  CA  . THR A 1 83  ? 28.37254 -21.30376 -27.38680 1.000 21.71873 ? 81  THR A CA  1 
ATOM   627  C  C   . THR A 1 83  ? 28.03883 -19.87220 -27.77942 1.000 22.03395 ? 81  THR A C   1 
ATOM   628  O  O   . THR A 1 83  ? 28.52255 -18.92952 -27.14932 1.000 21.88720 ? 81  THR A O   1 
ATOM   629  C  CB  . THR A 1 83  ? 27.42208 -21.76765 -26.25880 1.000 22.80739 ? 81  THR A CB  1 
ATOM   630  O  OG1 . THR A 1 83  ? 27.79338 -21.12216 -25.02688 1.000 18.95033 ? 81  THR A OG1 1 
ATOM   631  C  CG2 . THR A 1 83  ? 27.50772 -23.26911 -26.07174 1.000 22.53693 ? 81  THR A CG2 1 
ATOM   632  N  N   . PRO A 1 84  ? 27.19303 -19.67525 -28.79477 1.000 22.00783 ? 82  PRO A N   1 
ATOM   633  C  CA  . PRO A 1 84  ? 26.87591 -18.29631 -29.21711 1.000 21.56888 ? 82  PRO A CA  1 
ATOM   634  C  C   . PRO A 1 84  ? 26.08701 -17.50962 -28.19060 1.000 23.73139 ? 82  PRO A C   1 
ATOM   635  O  O   . PRO A 1 84  ? 26.20812 -16.27877 -28.14294 1.000 23.73706 ? 82  PRO A O   1 
ATOM   636  C  CB  . PRO A 1 84  ? 26.07264 -18.48602 -30.51520 1.000 22.87401 ? 82  PRO A CB  1 
ATOM   637  C  CG  . PRO A 1 84  ? 25.87179 -19.95575 -30.69125 1.000 26.09882 ? 82  PRO A CG  1 
ATOM   638  C  CD  . PRO A 1 84  ? 26.43271 -20.69729 -29.53688 1.000 24.30392 ? 82  PRO A CD  1 
ATOM   639  N  N   . ASP A 1 85  ? 25.27753 -18.16924 -27.38379 1.000 20.22144 ? 83  ASP A N   1 
ATOM   640  C  CA  . ASP A 1 85  ? 24.64220 -17.54775 -26.24174 1.000 20.10238 ? 83  ASP A CA  1 
ATOM   641  C  C   . ASP A 1 85  ? 25.23660 -18.16184 -24.97922 1.000 21.93397 ? 83  ASP A C   1 
ATOM   642  O  O   . ASP A 1 85  ? 25.86832 -19.21983 -25.04796 1.000 20.30668 ? 83  ASP A O   1 
ATOM   643  C  CB  . ASP A 1 85  ? 23.13227 -17.78444 -26.28019 1.000 22.85898 ? 83  ASP A CB  1 
ATOM   644  C  CG  . ASP A 1 85  ? 22.44238 -16.92825 -27.32916 1.000 31.74218 ? 83  ASP A CG  1 
ATOM   645  O  OD1 . ASP A 1 85  ? 22.64379 -15.70166 -27.34122 1.000 33.25187 ? 83  ASP A OD1 1 
ATOM   646  O  OD2 . ASP A 1 85  ? 21.66981 -17.49080 -28.12744 1.000 36.19473 ? 83  ASP A OD2 1 
ATOM   647  N  N   . PRO A 1 86  ? 25.10484 -17.51026 -23.82344 1.000 17.93843 ? 84  PRO A N   1 
ATOM   648  C  CA  . PRO A 1 86  ? 25.70872 -18.06259 -22.60035 1.000 18.84862 ? 84  PRO A CA  1 
ATOM   649  C  C   . PRO A 1 86  ? 25.25914 -19.50099 -22.36580 1.000 18.19705 ? 84  PRO A C   1 
ATOM   650  O  O   . PRO A 1 86  ? 24.09139 -19.84875 -22.56910 1.000 18.58001 ? 84  PRO A O   1 
ATOM   651  C  CB  . PRO A 1 86  ? 25.20969 -17.11464 -21.50372 1.000 21.30405 ? 84  PRO A CB  1 
ATOM   652  C  CG  . PRO A 1 86  ? 25.03127 -15.78070 -22.23777 1.000 20.32743 ? 84  PRO A CG  1 
ATOM   653  C  CD  . PRO A 1 86  ? 24.50017 -16.18265 -23.59642 1.000 21.26238 ? 84  PRO A CD  1 
ATOM   654  N  N   . ILE A 1 87  ? 26.20534 -20.34574 -21.94574 1.000 15.96778 ? 85  ILE A N   1 
ATOM   655  C  CA  . ILE A 1 87  ? 25.90073 -21.76879 -21.80843 1.000 16.28452 ? 85  ILE A CA  1 
ATOM   656  C  C   . ILE A 1 87  ? 24.87237 -22.00995 -20.70538 1.000 18.49624 ? 85  ILE A C   1 
ATOM   657  O  O   . ILE A 1 87  ? 24.84478 -21.32169 -19.67128 1.000 17.25942 ? 85  ILE A O   1 
ATOM   658  C  CB  . ILE A 1 87  ? 27.16970 -22.59626 -21.55495 1.000 18.33809 ? 85  ILE A CB  1 
ATOM   659  C  CG1 . ILE A 1 87  ? 26.80986 -24.08657 -21.73011 1.000 20.34587 ? 85  ILE A CG1 1 
ATOM   660  C  CG2 . ILE A 1 87  ? 27.75593 -22.26603 -20.17864 1.000 18.88585 ? 85  ILE A CG2 1 
ATOM   661  C  CD1 . ILE A 1 87  ? 27.96030 -24.99891 -21.94528 1.000 25.69004 ? 85  ILE A CD1 1 
ATOM   662  N  N   . SER A 1 88  ? 24.03289 -23.01655 -20.91572 1.000 17.27143 ? 86  SER A N   1 
ATOM   663  C  CA  . SER A 1 88  ? 22.99613 -23.33902 -19.95209 1.000 17.06442 ? 86  SER A CA  1 
ATOM   664  C  C   . SER A 1 88  ? 23.36561 -24.58553 -19.15622 1.000 18.57392 ? 86  SER A C   1 
ATOM   665  O  O   . SER A 1 88  ? 23.63863 -25.63572 -19.75519 1.000 17.20127 ? 86  SER A O   1 
ATOM   666  C  CB  . SER A 1 88  ? 21.67145 -23.55733 -20.66551 1.000 17.50957 ? 86  SER A CB  1 
ATOM   667  O  OG  . SER A 1 88  ? 20.74732 -24.19803 -19.80388 1.000 18.64081 ? 86  SER A OG  1 
ATOM   668  N  N   . PRO A 1 89  ? 23.36042 -24.52596 -17.82028 1.000 16.38344 ? 87  PRO A N   1 
ATOM   669  C  CA  . PRO A 1 89  ? 23.57361 -25.74440 -17.03077 1.000 15.62883 ? 87  PRO A CA  1 
ATOM   670  C  C   . PRO A 1 89  ? 22.40783 -26.70731 -17.20758 1.000 15.84929 ? 87  PRO A C   1 
ATOM   671  O  O   . PRO A 1 89  ? 21.24431 -26.30045 -17.23183 1.000 17.00479 ? 87  PRO A O   1 
ATOM   672  C  CB  . PRO A 1 89  ? 23.65424 -25.23017 -15.58811 1.000 14.56980 ? 87  PRO A CB  1 
ATOM   673  C  CG  . PRO A 1 89  ? 23.93057 -23.74351 -15.70906 1.000 17.12388 ? 87  PRO A CG  1 
ATOM   674  C  CD  . PRO A 1 89  ? 23.19735 -23.33846 -16.96165 1.000 15.83938 ? 87  PRO A CD  1 
ATOM   675  N  N   . CYS A 1 90  ? 22.72749 -27.99461 -17.34288 1.000 15.01955 ? 88  CYS A N   1 
ATOM   676  C  CA  . CYS A 1 90  ? 21.67186 -28.99286 -17.44351 1.000 13.72636 ? 88  CYS A CA  1 
ATOM   677  C  C   . CYS A 1 90  ? 20.95744 -29.18347 -16.10867 1.000 15.71872 ? 88  CYS A C   1 
ATOM   678  O  O   . CYS A 1 90  ? 21.42240 -28.75227 -15.04766 1.000 17.31326 ? 88  CYS A O   1 
ATOM   679  C  CB  . CYS A 1 90  ? 22.23929 -30.31800 -17.96250 1.000 12.65368 ? 88  CYS A CB  1 
ATOM   680  S  SG  . CYS A 1 90  ? 22.92425 -31.43121 -16.71090 1.000 16.33531 ? 88  CYS A SG  1 
ATOM   681  N  N   . GLY A 1 91  ? 19.78992 -29.83374 -16.18316 1.000 14.47713 ? 89  GLY A N   1 
ATOM   682  C  CA  . GLY A 1 91  ? 18.96294 -30.00003 -14.99505 1.000 13.31447 ? 89  GLY A CA  1 
ATOM   683  C  C   . GLY A 1 91  ? 19.64972 -30.79214 -13.89437 1.000 15.03641 ? 89  GLY A C   1 
ATOM   684  O  O   . GLY A 1 91  ? 19.43343 -30.53268 -12.70696 1.000 13.09339 ? 89  GLY A O   1 
ATOM   685  N  N   . ALA A 1 92  ? 20.45648 -31.79351 -14.26493 1.000 15.47921 ? 90  ALA A N   1 
ATOM   686  C  CA  . ALA A 1 92  ? 21.14380 -32.57079 -13.23285 1.000 13.87123 ? 90  ALA A CA  1 
ATOM   687  C  C   . ALA A 1 92  ? 22.07239 -31.68016 -12.41710 1.000 15.15043 ? 90  ALA A C   1 
ATOM   688  O  O   . ALA A 1 92  ? 22.11785 -31.76962 -11.17331 1.000 14.44613 ? 90  ALA A O   1 
ATOM   689  C  CB  . ALA A 1 92  ? 21.91555 -33.72617 -13.87002 1.000 15.48079 ? 90  ALA A CB  1 
ATOM   690  N  N   . CYS A 1 93  ? 22.80735 -30.79966 -13.10232 1.000 13.88668 ? 91  CYS A N   1 
ATOM   691  C  CA  . CYS A 1 93  ? 23.69966 -29.87125 -12.41991 1.000 14.22778 ? 91  CYS A CA  1 
ATOM   692  C  C   . CYS A 1 93  ? 22.91037 -28.90703 -11.55487 1.000 14.98988 ? 91  CYS A C   1 
ATOM   693  O  O   . CYS A 1 93  ? 23.31995 -28.59468 -10.43153 1.000 14.23473 ? 91  CYS A O   1 
ATOM   694  C  CB  . CYS A 1 93  ? 24.51921 -29.10191 -13.43451 1.000 15.13698 ? 91  CYS A CB  1 
ATOM   695  S  SG  . CYS A 1 93  ? 25.76303 -30.16531 -14.17015 1.000 14.55921 ? 91  CYS A SG  1 
ATOM   696  N  N   . ARG A 1 94  ? 21.79228 -28.40312 -12.07827 1.000 13.11519 ? 92  ARG A N   1 
ATOM   697  C  CA  . ARG A 1 94  ? 20.95318 -27.50705 -11.28170 1.000 14.82339 ? 92  ARG A CA  1 
ATOM   698  C  C   . ARG A 1 94  ? 20.50898 -28.16741 -9.98062  1.000 15.44491 ? 92  ARG A C   1 
ATOM   699  O  O   . ARG A 1 94  ? 20.38817 -27.48761 -8.95080  1.000 15.58125 ? 92  ARG A O   1 
ATOM   700  C  CB  . ARG A 1 94  ? 19.74922 -27.05813 -12.10397 1.000 15.46243 ? 92  ARG A CB  1 
ATOM   701  C  CG  . ARG A 1 94  ? 20.15172 -26.21004 -13.32271 1.000 14.78835 ? 92  ARG A CG  1 
ATOM   702  C  CD  . ARG A 1 94  ? 18.94597 -25.85758 -14.20880 1.000 15.09268 ? 92  ARG A CD  1 
ATOM   703  N  NE  . ARG A 1 94  ? 19.37557 -25.24978 -15.47273 1.000 16.82759 ? 92  ARG A NE  1 
ATOM   704  C  CZ  . ARG A 1 94  ? 18.60248 -24.48172 -16.23033 1.000 16.26414 ? 92  ARG A CZ  1 
ATOM   705  N  NH1 . ARG A 1 94  ? 17.38883 -24.13360 -15.84113 1.000 16.56071 ? 92  ARG A NH1 1 
ATOM   706  N  NH2 . ARG A 1 94  ? 19.06030 -24.06049 -17.41158 1.000 16.92672 ? 92  ARG A NH2 1 
ATOM   707  N  N   . GLN A 1 95  ? 20.28495 -29.48417 -9.99747  1.000 14.45744 ? 93  GLN A N   1 
ATOM   708  C  CA  . GLN A 1 95  ? 19.85872 -30.18481 -8.78155  1.000 13.67047 ? 93  GLN A CA  1 
ATOM   709  C  C   . GLN A 1 95  ? 20.99840 -30.32463 -7.77818  1.000 14.98525 ? 93  GLN A C   1 
ATOM   710  O  O   . GLN A 1 95  ? 20.77359 -30.25890 -6.55780  1.000 16.19228 ? 93  GLN A O   1 
ATOM   711  C  CB  . GLN A 1 95  ? 19.30398 -31.55964 -9.14020  1.000 13.10409 ? 93  GLN A CB  1 
ATOM   712  C  CG  . GLN A 1 95  ? 18.63173 -32.29027 -7.97017  1.000 15.89707 ? 93  GLN A CG  1 
ATOM   713  C  CD  . GLN A 1 95  ? 17.37002 -31.59270 -7.51435  1.000 17.23272 ? 93  GLN A CD  1 
ATOM   714  O  OE1 . GLN A 1 95  ? 16.47916 -31.30433 -8.31265  1.000 15.86196 ? 93  GLN A OE1 1 
ATOM   715  N  NE2 . GLN A 1 95  ? 17.29901 -31.28795 -6.21861  1.000 17.46033 ? 93  GLN A NE2 1 
ATOM   716  N  N   . VAL A 1 96  ? 22.22189 -30.53962 -8.26581  1.000 14.56458 ? 94  VAL A N   1 
ATOM   717  C  CA  . VAL A 1 96  ? 23.37575 -30.54972 -7.36657  1.000 13.61852 ? 94  VAL A CA  1 
ATOM   718  C  C   . VAL A 1 96  ? 23.61852 -29.15371 -6.80415  1.000 15.33853 ? 94  VAL A C   1 
ATOM   719  O  O   . VAL A 1 96  ? 23.96088 -29.00149 -5.62490  1.000 15.45448 ? 94  VAL A O   1 
ATOM   720  C  CB  . VAL A 1 96  ? 24.61753 -31.10834 -8.08966  1.000 13.24053 ? 94  VAL A CB  1 
ATOM   721  C  CG1 . VAL A 1 96  ? 25.88081 -30.95963 -7.22956  1.000 15.74782 ? 94  VAL A CG1 1 
ATOM   722  C  CG2 . VAL A 1 96  ? 24.41300 -32.60205 -8.41215  1.000 14.61115 ? 94  VAL A CG2 1 
ATOM   723  N  N   . MET A 1 97  ? 23.42683 -28.11551 -7.62801  1.000 13.52856 ? 95  MET A N   1 
ATOM   724  C  CA  . MET A 1 97  ? 23.55211 -26.74705 -7.14065  1.000 14.75459 ? 95  MET A CA  1 
ATOM   725  C  C   . MET A 1 97  ? 22.57400 -26.51047 -6.00191  1.000 16.25348 ? 95  MET A C   1 
ATOM   726  O  O   . MET A 1 97  ? 22.93070 -25.90969 -4.98311  1.000 17.57432 ? 95  MET A O   1 
ATOM   727  C  CB  . MET A 1 97  ? 23.28143 -25.76032 -8.28401  1.000 16.29672 ? 95  MET A CB  1 
ATOM   728  C  CG  . MET A 1 97  ? 24.39226 -25.80238 -9.32470  1.000 18.43615 ? 95  MET A CG  1 
ATOM   729  S  SD  . MET A 1 97  ? 23.98000 -25.09788 -10.94740 1.000 22.13555 ? 95  MET A SD  1 
ATOM   730  C  CE  . MET A 1 97  ? 23.19830 -23.61118 -10.47023 1.000 16.27325 ? 95  MET A CE  1 
ATOM   731  N  N   . ALA A 1 98  ? 21.33702 -26.99820 -6.15109  1.000 13.24135 ? 96  ALA A N   1 
ATOM   732  C  CA  . ALA A 1 98  ? 20.32777 -26.76948 -5.11430  1.000 15.57307 ? 96  ALA A CA  1 
ATOM   733  C  C   . ALA A 1 98  ? 20.64735 -27.53152 -3.82954  1.000 18.22726 ? 96  ALA A C   1 
ATOM   734  O  O   . ALA A 1 98  ? 20.22290 -27.11481 -2.74603  1.000 18.44399 ? 96  ALA A O   1 
ATOM   735  C  CB  . ALA A 1 98  ? 18.93522 -27.15427 -5.63075  1.000 16.83378 ? 96  ALA A CB  1 
ATOM   736  N  N   . GLU A 1 99  ? 21.37194 -28.65131 -3.92896  1.000 14.91764 ? 97  GLU A N   1 
ATOM   737  C  CA  . GLU A 1 99  ? 21.76196 -29.39742 -2.72864  1.000 17.05476 ? 97  GLU A CA  1 
ATOM   738  C  C   . GLU A 1 99  ? 22.68042 -28.57450 -1.83028  1.000 19.62836 ? 97  GLU A C   1 
ATOM   739  O  O   . GLU A 1 99  ? 22.60147 -28.66618 -0.59634  1.000 18.80497 ? 97  GLU A O   1 
ATOM   740  C  CB  . GLU A 1 99  ? 22.46379 -30.70075 -3.12890  1.000 16.50432 ? 97  GLU A CB  1 
ATOM   741  C  CG  . GLU A 1 99  ? 22.87338 -31.64317 -1.96817  1.000 15.72650 ? 97  GLU A CG  1 
ATOM   742  C  CD  . GLU A 1 99  ? 21.71127 -32.48605 -1.43878  1.000 18.41442 ? 97  GLU A CD  1 
ATOM   743  O  OE1 . GLU A 1 99  ? 20.67192 -32.59830 -2.13616  1.000 17.32104 ? 97  GLU A OE1 1 
ATOM   744  O  OE2 . GLU A 1 99  ? 21.85264 -33.09774 -0.34477  1.000 19.06730 ? 97  GLU A OE2 1 
ATOM   745  N  N   . PHE A 1 100 ? 23.57593 -27.77561 -2.42437  1.000 17.62336 ? 98  PHE A N   1 
ATOM   746  C  CA  . PHE A 1 100 ? 24.66248 -27.16755 -1.66478  1.000 17.33379 ? 98  PHE A CA  1 
ATOM   747  C  C   . PHE A 1 100 ? 24.60535 -25.65007 -1.56827  1.000 18.55678 ? 98  PHE A C   1 
ATOM   748  O  O   . PHE A 1 100 ? 25.34534 -25.08241 -0.75367  1.000 20.03581 ? 98  PHE A O   1 
ATOM   749  C  CB  . PHE A 1 100 ? 26.02119 -27.58052 -2.25674  1.000 18.52907 ? 98  PHE A CB  1 
ATOM   750  C  CG  . PHE A 1 100 ? 26.29433 -29.03991 -2.12570  1.000 20.63779 ? 98  PHE A CG  1 
ATOM   751  C  CD1 . PHE A 1 100 ? 26.51854 -29.60306 -0.87410  1.000 16.74557 ? 98  PHE A CD1 1 
ATOM   752  C  CD2 . PHE A 1 100 ? 26.24506 -29.87276 -3.24054  1.000 16.93811 ? 98  PHE A CD2 1 
ATOM   753  C  CE1 . PHE A 1 100 ? 26.74162 -30.96313 -0.73422  1.000 14.68548 ? 98  PHE A CE1 1 
ATOM   754  C  CE2 . PHE A 1 100 ? 26.45664 -31.23832 -3.11234  1.000 16.47665 ? 98  PHE A CE2 1 
ATOM   755  C  CZ  . PHE A 1 100 ? 26.69885 -31.79203 -1.85446  1.000 17.07125 ? 98  PHE A CZ  1 
ATOM   756  N  N   . CYS A 1 101 ? 23.75020 -24.98214 -2.34126  1.000 18.29646 ? 99  CYS A N   1 
ATOM   757  C  CA  . CYS A 1 101 ? 23.76584 -23.52951 -2.45229  1.000 16.85951 ? 99  CYS A CA  1 
ATOM   758  C  C   . CYS A 1 101 ? 22.45434 -22.92538 -1.98142  1.000 16.24582 ? 99  CYS A C   1 
ATOM   759  O  O   . CYS A 1 101 ? 21.39105 -23.54641 -2.06864  1.000 18.32737 ? 99  CYS A O   1 
ATOM   760  C  CB  . CYS A 1 101 ? 23.99990 -23.08351 -3.89766  1.000 19.00319 ? 99  CYS A CB  1 
ATOM   761  S  SG  . CYS A 1 101 ? 25.51108 -23.74553 -4.63153  1.000 17.25836 ? 99  CYS A SG  1 
ATOM   762  N  N   . ALA A 1 102 ? 22.54017 -21.67929 -1.52577  1.000 18.64310 ? 100 ALA A N   1 
ATOM   763  C  CA  . ALA A 1 102 ? 21.34371 -20.93453 -1.19932  1.000 20.09502 ? 100 ALA A CA  1 
ATOM   764  C  C   . ALA A 1 102 ? 20.55653 -20.62529 -2.46762  1.000 21.89675 ? 100 ALA A C   1 
ATOM   765  O  O   . ALA A 1 102 ? 21.14409 -20.41076 -3.53764  1.000 21.43465 ? 100 ALA A O   1 
ATOM   766  C  CB  . ALA A 1 102 ? 21.70079 -19.63193 -0.48594  1.000 21.82012 ? 100 ALA A CB  1 
ATOM   767  N  N   . PRO A 1 103 ? 19.22785 -20.58546 -2.36689  1.000 21.72478 ? 101 PRO A N   1 
ATOM   768  C  CA  . PRO A 1 103 ? 18.40236 -20.24358 -3.53627  1.000 24.15102 ? 101 PRO A CA  1 
ATOM   769  C  C   . PRO A 1 103 ? 18.85763 -18.99575 -4.25718  1.000 22.78420 ? 101 PRO A C   1 
ATOM   770  O  O   . PRO A 1 103 ? 18.83623 -18.95388 -5.49150  1.000 21.39923 ? 101 PRO A O   1 
ATOM   771  C  CB  . PRO A 1 103 ? 17.00384 -20.06845 -2.92967  1.000 24.86435 ? 101 PRO A CB  1 
ATOM   772  C  CG  . PRO A 1 103 ? 17.01237 -20.93549 -1.70917  1.000 24.00354 ? 101 PRO A CG  1 
ATOM   773  C  CD  . PRO A 1 103 ? 18.41367 -20.86881 -1.16968  1.000 24.15631 ? 101 PRO A CD  1 
ATOM   774  N  N   . ASP A 1 104 ? 19.28610 -17.96560 -3.52964  1.000 21.93408 ? 102 ASP A N   1 
ATOM   775  C  CA  . ASP A 1 104 ? 19.62508 -16.71979 -4.18274  1.000 22.08454 ? 102 ASP A CA  1 
ATOM   776  C  C   . ASP A 1 104 ? 21.10831 -16.63081 -4.55115  1.000 20.81475 ? 102 ASP A C   1 
ATOM   777  O  O   . ASP A 1 104 ? 21.58728 -15.54496 -4.89914  1.000 21.05684 ? 102 ASP A O   1 
ATOM   778  C  CB  . ASP A 1 104 ? 19.20256 -15.54570 -3.28535  1.000 25.58323 ? 102 ASP A CB  1 
ATOM   779  C  CG  . ASP A 1 104 ? 17.67534 -15.33680 -3.26602  1.000 35.53104 ? 102 ASP A CG  1 
ATOM   780  O  OD1 . ASP A 1 104 ? 16.97681 -15.72538 -4.23263  1.000 34.00222 ? 102 ASP A OD1 1 
ATOM   781  O  OD2 . ASP A 1 104 ? 17.16236 -14.79007 -2.25935  1.000 39.97755 ? 102 ASP A OD2 1 
ATOM   782  N  N   . MET A 1 105 ? 21.84249 -17.74462 -4.52675  1.000 19.43991 ? 103 MET A N   1 
ATOM   783  C  CA  . MET A 1 105 ? 23.26290 -17.65984 -4.84894  1.000 18.01647 ? 103 MET A CA  1 
ATOM   784  C  C   . MET A 1 105 ? 23.42934 -17.32858 -6.32554  1.000 20.04164 ? 103 MET A C   1 
ATOM   785  O  O   . MET A 1 105 ? 22.74989 -17.92469 -7.17797  1.000 18.98618 ? 103 MET A O   1 
ATOM   786  C  CB  . MET A 1 105 ? 24.00314 -18.94423 -4.42878  1.000 18.52306 ? 103 MET A CB  1 
ATOM   787  C  CG  . MET A 1 105 ? 25.53767 -18.87692 -4.54558  1.000 19.39016 ? 103 MET A CG  1 
ATOM   788  S  SD  . MET A 1 105 ? 26.44010 -20.40713 -4.91651  1.000 18.54690 ? 103 MET A SD  1 
ATOM   789  C  CE  . MET A 1 105 ? 26.10427 -20.70912 -6.67410  1.000 16.14226 ? 103 MET A CE  1 
ATOM   790  N  N   . PRO A 1 106 ? 24.25137 -16.33762 -6.65802  1.000 21.23986 ? 104 PRO A N   1 
ATOM   791  C  CA  . PRO A 1 106 ? 24.35534 -15.89765 -8.05411  1.000 21.67192 ? 104 PRO A CA  1 
ATOM   792  C  C   . PRO A 1 106 ? 25.10336 -16.90230 -8.91154  1.000 20.31584 ? 104 PRO A C   1 
ATOM   793  O  O   . PRO A 1 106 ? 26.07804 -17.52507 -8.48201  1.000 17.82728 ? 104 PRO A O   1 
ATOM   794  C  CB  . PRO A 1 106 ? 25.12735 -14.57332 -7.97374  1.000 22.30010 ? 104 PRO A CB  1 
ATOM   795  C  CG  . PRO A 1 106 ? 25.52395 -14.39553 -6.54690  1.000 25.45194 ? 104 PRO A CG  1 
ATOM   796  C  CD  . PRO A 1 106 ? 25.08130 -15.54501 -5.73310  1.000 22.17941 ? 104 PRO A CD  1 
ATOM   797  N  N   . VAL A 1 107 ? 24.64449 -17.01678 -10.15067 1.000 17.94899 ? 105 VAL A N   1 
ATOM   798  C  CA  . VAL A 1 107 ? 25.25014 -17.86482 -11.15896 1.000 18.84384 ? 105 VAL A CA  1 
ATOM   799  C  C   . VAL A 1 107 ? 25.48256 -17.00891 -12.39505 1.000 21.00691 ? 105 VAL A C   1 
ATOM   800  O  O   . VAL A 1 107 ? 24.56616 -16.31526 -12.84870 1.000 19.71070 ? 105 VAL A O   1 
ATOM   801  C  CB  . VAL A 1 107 ? 24.34013 -19.06075 -11.49030 1.000 17.41554 ? 105 VAL A CB  1 
ATOM   802  C  CG1 . VAL A 1 107 ? 24.97200 -19.90219 -12.59395 1.000 17.84795 ? 105 VAL A CG1 1 
ATOM   803  C  CG2 . VAL A 1 107 ? 24.06749 -19.89443 -10.24448 1.000 16.91617 ? 105 VAL A CG2 1 
ATOM   804  N  N   . THR A 1 108 ? 26.70745 -17.02447 -12.91455 1.000 17.99683 ? 106 THR A N   1 
ATOM   805  C  CA  . THR A 1 108 ? 27.02966 -16.33065 -14.15570 1.000 17.41947 ? 106 THR A CA  1 
ATOM   806  C  C   . THR A 1 108 ? 27.26618 -17.34778 -15.26234 1.000 18.42218 ? 106 THR A C   1 
ATOM   807  O  O   . THR A 1 108 ? 28.09996 -18.24803 -15.11513 1.000 17.61175 ? 106 THR A O   1 
ATOM   808  C  CB  . THR A 1 108 ? 28.26841 -15.45108 -13.99454 1.000 20.88343 ? 106 THR A CB  1 
ATOM   809  O  OG1 . THR A 1 108 ? 28.01977 -14.46716 -12.97549 1.000 21.88341 ? 106 THR A OG1 1 
ATOM   810  C  CG2 . THR A 1 108 ? 28.58718 -14.72650 -15.33044 1.000 22.01290 ? 106 THR A CG2 1 
ATOM   811  N  N   . LEU A 1 109 ? 26.55997 -17.18304 -16.37492 1.000 16.67629 ? 107 LEU A N   1 
ATOM   812  C  CA  . LEU A 1 109 ? 26.69722 -18.06269 -17.52727 1.000 18.00337 ? 107 LEU A CA  1 
ATOM   813  C  C   . LEU A 1 109 ? 27.43545 -17.30570 -18.62036 1.000 18.20309 ? 107 LEU A C   1 
ATOM   814  O  O   . LEU A 1 109 ? 27.15606 -16.12439 -18.85367 1.000 19.30878 ? 107 LEU A O   1 
ATOM   815  C  CB  . LEU A 1 109 ? 25.32566 -18.53122 -18.01437 1.000 16.73896 ? 107 LEU A CB  1 
ATOM   816  C  CG  . LEU A 1 109 ? 24.47209 -19.14650 -16.89862 1.000 17.07280 ? 107 LEU A CG  1 
ATOM   817  C  CD1 . LEU A 1 109 ? 23.09931 -19.55915 -17.38928 1.000 20.00176 ? 107 LEU A CD1 1 
ATOM   818  C  CD2 . LEU A 1 109 ? 25.21015 -20.33287 -16.26238 1.000 19.22135 ? 107 LEU A CD2 1 
ATOM   819  N  N   . VAL A 1 110 ? 28.38596 -17.98024 -19.27217 1.000 17.71438 ? 108 VAL A N   1 
ATOM   820  C  CA  . VAL A 1 110 ? 29.29179 -17.35980 -20.24079 1.000 18.09000 ? 108 VAL A CA  1 
ATOM   821  C  C   . VAL A 1 110 ? 29.23715 -18.13985 -21.55256 1.000 20.49584 ? 108 VAL A C   1 
ATOM   822  O  O   . VAL A 1 110 ? 29.15519 -19.37336 -21.55190 1.000 18.21689 ? 108 VAL A O   1 
ATOM   823  C  CB  . VAL A 1 110 ? 30.74496 -17.32780 -19.70990 1.000 20.40652 ? 108 VAL A CB  1 
ATOM   824  C  CG1 . VAL A 1 110 ? 31.67954 -16.49693 -20.61757 1.000 23.57644 ? 108 VAL A CG1 1 
ATOM   825  C  CG2 . VAL A 1 110 ? 30.78948 -16.82904 -18.26032 1.000 22.49111 ? 108 VAL A CG2 1 
ATOM   826  N  N   . GLY A 1 111 ? 29.31869 -17.42232 -22.67043 1.000 20.78520 ? 109 GLY A N   1 
ATOM   827  C  CA  . GLY A 1 111 ? 29.47279 -18.03959 -23.97683 1.000 18.13705 ? 109 GLY A CA  1 
ATOM   828  C  C   . GLY A 1 111 ? 30.68263 -17.46449 -24.69083 1.000 21.32610 ? 109 GLY A C   1 
ATOM   829  O  O   . GLY A 1 111 ? 31.55629 -16.85770 -24.06198 1.000 21.20737 ? 109 GLY A O   1 
ATOM   830  N  N   . ASP A 1 112 ? 30.75219 -17.64788 -26.00498 1.000 20.26789 ? 110 ASP A N   1 
ATOM   831  C  CA  . ASP A 1 112 ? 31.86207 -17.09933 -26.76716 1.000 22.17861 ? 110 ASP A CA  1 
ATOM   832  C  C   . ASP A 1 112 ? 31.68014 -15.59319 -26.96137 1.000 24.51815 ? 110 ASP A C   1 
ATOM   833  O  O   . ASP A 1 112 ? 30.57481 -15.05588 -26.84902 1.000 22.93563 ? 110 ASP A O   1 
ATOM   834  C  CB  . ASP A 1 112 ? 31.95826 -17.79963 -28.12090 1.000 23.66226 ? 110 ASP A CB  1 
ATOM   835  C  CG  . ASP A 1 112 ? 32.67716 -19.13024 -28.03575 1.000 20.54595 ? 110 ASP A CG  1 
ATOM   836  O  OD1 . ASP A 1 112 ? 33.55061 -19.29404 -27.15360 1.000 22.05762 ? 110 ASP A OD1 1 
ATOM   837  O  OD2 . ASP A 1 112 ? 32.37126 -20.01528 -28.86202 1.000 25.48337 ? 110 ASP A OD2 1 
ATOM   838  N  N   . ASN A 1 113 ? 32.79430 -14.91295 -27.23962 1.000 24.92720 ? 111 ASN A N   1 
ATOM   839  C  CA  . ASN A 1 113 ? 32.78286 -13.48251 -27.55101 1.000 27.90840 ? 111 ASN A CA  1 
ATOM   840  C  C   . ASN A 1 113 ? 32.20116 -12.66338 -26.39935 1.000 31.05362 ? 111 ASN A C   1 
ATOM   841  O  O   . ASN A 1 113 ? 31.49600 -11.67367 -26.60752 1.000 33.36269 ? 111 ASN A O   1 
ATOM   842  C  CB  . ASN A 1 113 ? 32.03138 -13.22550 -28.85760 1.000 30.94230 ? 111 ASN A CB  1 
ATOM   843  C  CG  . ASN A 1 113 ? 32.73684 -13.83891 -30.05461 1.000 41.62306 ? 111 ASN A CG  1 
ATOM   844  O  OD1 . ASN A 1 113 ? 33.97013 -13.97206 -30.06813 1.000 44.25254 ? 111 ASN A OD1 1 
ATOM   845  N  ND2 . ASN A 1 113 ? 31.95917 -14.26101 -31.04641 1.000 46.73129 ? 111 ASN A ND2 1 
ATOM   846  N  N   . GLY A 1 114 ? 32.48928 -13.09802 -25.17168 1.000 28.71303 ? 112 GLY A N   1 
ATOM   847  C  CA  . GLY A 1 114 ? 32.16794 -12.34771 -23.97565 1.000 33.21273 ? 112 GLY A CA  1 
ATOM   848  C  C   . GLY A 1 114 ? 30.71125 -12.29459 -23.56864 1.000 32.57947 ? 112 GLY A C   1 
ATOM   849  O  O   . GLY A 1 114 ? 30.38711 -11.56417 -22.62519 1.000 33.86616 ? 112 GLY A O   1 
ATOM   850  N  N   . VAL A 1 115 ? 29.81307 -13.03633 -24.22366 1.000 25.67833 ? 113 VAL A N   1 
ATOM   851  C  CA  . VAL A 1 115 ? 28.40407 -12.94336 -23.84990 1.000 25.58717 ? 113 VAL A CA  1 
ATOM   852  C  C   . VAL A 1 115 ? 28.20002 -13.58158 -22.47968 1.000 25.24023 ? 113 VAL A C   1 
ATOM   853  O  O   . VAL A 1 115 ? 28.81220 -14.61160 -22.15449 1.000 23.66932 ? 113 VAL A O   1 
ATOM   854  C  CB  . VAL A 1 115 ? 27.48907 -13.57059 -24.92093 1.000 27.36856 ? 113 VAL A CB  1 
ATOM   855  C  CG1 . VAL A 1 115 ? 27.69012 -12.88805 -26.27762 1.000 27.80653 ? 113 VAL A CG1 1 
ATOM   856  C  CG2 . VAL A 1 115 ? 27.72447 -15.07969 -25.04313 1.000 23.38432 ? 113 VAL A CG2 1 
ATOM   857  N  N   . THR A 1 116 ? 27.38226 -12.93292 -21.64458 1.000 25.04361 ? 114 THR A N   1 
ATOM   858  C  CA  . THR A 1 116 ? 27.12988 -13.39554 -20.28325 1.000 23.73174 ? 114 THR A CA  1 
ATOM   859  C  C   . THR A 1 116 ? 25.64995 -13.25527 -19.94968 1.000 25.97895 ? 114 THR A C   1 
ATOM   860  O  O   . THR A 1 116 ? 24.90838 -12.49697 -20.58488 1.000 28.17477 ? 114 THR A O   1 
ATOM   861  C  CB  . THR A 1 116 ? 27.96908 -12.64172 -19.22391 1.000 26.58311 ? 114 THR A CB  1 
ATOM   862  O  OG1 . THR A 1 116 ? 27.65334 -11.24357 -19.26544 1.000 31.62902 ? 114 THR A OG1 1 
ATOM   863  C  CG2 . THR A 1 116 ? 29.46519 -12.83757 -19.43025 1.000 28.39376 ? 114 THR A CG2 1 
ATOM   864  N  N   . LYS A 1 117 ? 25.22883 -14.00999 -18.93136 1.000 22.73412 ? 115 LYS A N   1 
ATOM   865  C  CA  . LYS A 1 117 ? 23.87356 -13.97528 -18.39927 1.000 21.47433 ? 115 LYS A CA  1 
ATOM   866  C  C   . LYS A 1 117 ? 23.95440 -14.14645 -16.89159 1.000 24.64548 ? 115 LYS A C   1 
ATOM   867  O  O   . LYS A 1 117 ? 24.67734 -15.02155 -16.41134 1.000 21.09214 ? 115 LYS A O   1 
ATOM   868  C  CB  . LYS A 1 117 ? 23.00984 -15.08197 -19.01257 1.000 21.49326 ? 115 LYS A CB  1 
ATOM   869  C  CG  . LYS A 1 117 ? 21.63159 -15.19665 -18.41028 1.000 25.37132 ? 115 LYS A CG  1 
ATOM   870  C  CD  . LYS A 1 117 ? 20.85758 -16.34896 -19.03183 1.000 27.68877 ? 115 LYS A CD  1 
ATOM   871  C  CE  . LYS A 1 117 ? 19.58652 -16.60073 -18.25389 1.000 30.04094 ? 115 LYS A CE  1 
ATOM   872  N  NZ  . LYS A 1 117 ? 18.49922 -15.69800 -18.72389 1.000 31.51569 ? 115 LYS A NZ  1 
ATOM   873  N  N   . ALA A 1 118 ? 23.24338 -13.29642 -16.15122 1.000 21.13312 ? 116 ALA A N   1 
ATOM   874  C  CA  . ALA A 1 118 ? 23.23112 -13.34118 -14.69416 1.000 24.89053 ? 116 ALA A CA  1 
ATOM   875  C  C   . ALA A 1 118 ? 21.95094 -14.01362 -14.22475 1.000 21.00904 ? 116 ALA A C   1 
ATOM   876  O  O   . ALA A 1 118 ? 20.85596 -13.65033 -14.66448 1.000 20.77756 ? 116 ALA A O   1 
ATOM   877  C  CB  . ALA A 1 118 ? 23.33840 -11.93515 -14.09942 1.000 24.66265 ? 116 ALA A CB  1 
ATOM   878  N  N   . THR A 1 119 ? 22.08249 -14.99465 -13.33785 1.000 20.39901 ? 117 THR A N   1 
ATOM   879  C  CA  . THR A 1 119 ? 20.91043 -15.68334 -12.81918 1.000 18.34782 ? 117 THR A CA  1 
ATOM   880  C  C   . THR A 1 119 ? 21.23771 -16.15095 -11.39850 1.000 17.25783 ? 117 THR A C   1 
ATOM   881  O  O   . THR A 1 119 ? 22.21947 -15.70021 -10.79883 1.000 19.45140 ? 117 THR A O   1 
ATOM   882  C  CB  . THR A 1 119 ? 20.48548 -16.79847 -13.79612 1.000 22.50059 ? 117 THR A CB  1 
ATOM   883  O  OG1 . THR A 1 119 ? 19.23518 -17.37418 -13.39359 1.000 19.80383 ? 117 THR A OG1 1 
ATOM   884  C  CG2 . THR A 1 119 ? 21.55275 -17.87841 -13.93109 1.000 19.79050 ? 117 THR A CG2 1 
ATOM   885  N  N   . THR A 1 120 ? 20.38731 -17.01841 -10.84064 1.000 17.85303 ? 118 THR A N   1 
ATOM   886  C  CA  . THR A 1 120 ? 20.58452 -17.55026 -9.49485  1.000 19.06223 ? 118 THR A CA  1 
ATOM   887  C  C   . THR A 1 120 ? 20.19140 -19.02256 -9.48222  1.000 18.91507 ? 118 THR A C   1 
ATOM   888  O  O   . THR A 1 120 ? 19.55394 -19.52089 -10.41132 1.000 17.04002 ? 118 THR A O   1 
ATOM   889  C  CB  . THR A 1 120 ? 19.73989 -16.83031 -8.42793  1.000 19.11338 ? 118 THR A CB  1 
ATOM   890  O  OG1 . THR A 1 120 ? 18.35197 -17.06185 -8.67792  1.000 20.99819 ? 118 THR A OG1 1 
ATOM   891  C  CG2 . THR A 1 120 ? 20.01396 -15.31780 -8.40466  1.000 22.38153 ? 118 THR A CG2 1 
ATOM   892  N  N   . VAL A 1 121 ? 20.53690 -19.70677 -8.38630  1.000 15.71605 ? 119 VAL A N   1 
ATOM   893  C  CA  . VAL A 1 121 ? 20.16917 -21.11818 -8.22971  1.000 19.72761 ? 119 VAL A CA  1 
ATOM   894  C  C   . VAL A 1 121 ? 18.65208 -21.29499 -8.30210  1.000 20.96370 ? 119 VAL A C   1 
ATOM   895  O  O   . VAL A 1 121 ? 18.15146 -22.16808 -9.02089  1.000 18.85652 ? 119 VAL A O   1 
ATOM   896  C  CB  . VAL A 1 121 ? 20.76426 -21.67159 -6.91975  1.000 16.91755 ? 119 VAL A CB  1 
ATOM   897  C  CG1 . VAL A 1 121 ? 20.24528 -23.07647 -6.60155  1.000 21.46840 ? 119 VAL A CG1 1 
ATOM   898  C  CG2 . VAL A 1 121 ? 22.28155 -21.68843 -7.03550  1.000 14.88143 ? 119 VAL A CG2 1 
ATOM   899  N  N   . ARG A 1 122 ? 17.89524 -20.44306 -7.58656  1.000 18.83812 ? 120 ARG A N   1 
ATOM   900  C  CA  . ARG A 1 122 ? 16.43042 -20.52604 -7.59587  1.000 20.77604 ? 120 ARG A CA  1 
ATOM   901  C  C   . ARG A 1 122 ? 15.84779 -20.27509 -8.98611  1.000 19.39216 ? 120 ARG A C   1 
ATOM   902  O  O   . ARG A 1 122 ? 14.88669 -20.94216 -9.38754  1.000 21.69515 ? 120 ARG A O   1 
ATOM   903  C  CB  . ARG A 1 122 ? 15.83890 -19.52251 -6.58315  1.000 24.40370 ? 120 ARG A CB  1 
ATOM   904  C  CG  . ARG A 1 122 ? 14.33514 -19.17181 -6.76517  1.000 35.83409 ? 120 ARG A CG  1 
ATOM   905  C  CD  . ARG A 1 122 ? 13.30814 -19.75511 -5.73969  1.000 41.03547 ? 120 ARG A CD  1 
ATOM   906  N  NE  . ARG A 1 122 ? 11.97959 -19.94037 -6.34010  1.000 40.25394 ? 120 ARG A NE  1 
ATOM   907  C  CZ  . ARG A 1 122 ? 11.07805 -20.83960 -5.95774  1.000 27.69273 ? 120 ARG A CZ  1 
ATOM   908  N  NH1 . ARG A 1 122 ? 11.23274 -21.55102 -4.85979  1.000 39.28641 ? 120 ARG A NH1 1 
ATOM   909  N  NH2 . ARG A 1 122 ? 9.98506  -21.01621 -6.68934  1.000 35.85456 ? 120 ARG A NH2 1 
ATOM   910  N  N   . GLU A 1 123 ? 16.37467 -19.29233 -9.72146  1.000 18.53581 ? 121 GLU A N   1 
ATOM   911  C  CA  . GLU A 1 123 ? 15.80514 -19.01255 -11.04249 1.000 20.25416 ? 121 GLU A CA  1 
ATOM   912  C  C   . GLU A 1 123 ? 16.02755 -20.16789 -12.00272 1.000 19.53636 ? 121 GLU A C   1 
ATOM   913  O  O   . GLU A 1 123 ? 15.17946 -20.43476 -12.85834 1.000 20.84695 ? 121 GLU A O   1 
ATOM   914  C  CB  . GLU A 1 123 ? 16.36847 -17.72705 -11.65639 1.000 21.28686 ? 121 GLU A CB  1 
ATOM   915  C  CG  . GLU A 1 123 ? 16.36370 -16.52665 -10.75143 1.000 25.76430 ? 121 GLU A CG  1 
ATOM   916  C  CD  . GLU A 1 123 ? 16.56778 -15.23164 -11.51565 1.000 36.13387 ? 121 GLU A CD  1 
ATOM   917  O  OE1 . GLU A 1 123 ? 17.40925 -15.21630 -12.44574 1.000 34.64031 ? 121 GLU A OE1 1 
ATOM   918  O  OE2 . GLU A 1 123 ? 15.89820 -14.23247 -11.18154 1.000 43.45474 ? 121 GLU A OE2 1 
ATOM   919  N  N   . LEU A 1 124 ? 17.16623 -20.84711 -11.89013 1.000 17.15624 ? 122 LEU A N   1 
ATOM   920  C  CA  . LEU A 1 124 ? 17.45011 -21.97802 -12.77619 1.000 18.91097 ? 122 LEU A CA  1 
ATOM   921  C  C   . LEU A 1 124 ? 16.62813 -23.21306 -12.41693 1.000 18.15291 ? 122 LEU A C   1 
ATOM   922  O  O   . LEU A 1 124 ? 16.36235 -24.05691 -13.28661 1.000 16.26363 ? 122 LEU A O   1 
ATOM   923  C  CB  . LEU A 1 124 ? 18.94739 -22.29826 -12.72787 1.000 17.70458 ? 122 LEU A CB  1 
ATOM   924  C  CG  . LEU A 1 124 ? 19.86690 -21.26848 -13.39670 1.000 17.41713 ? 122 LEU A CG  1 
ATOM   925  C  CD1 . LEU A 1 124 ? 21.34503 -21.53865 -13.06856 1.000 18.13390 ? 122 LEU A CD1 1 
ATOM   926  C  CD2 . LEU A 1 124 ? 19.63017 -21.25777 -14.90585 1.000 18.88962 ? 122 LEU A CD2 1 
ATOM   927  N  N   . LEU A 1 125 ? 16.22222 -23.35852 -11.15419 1.000 17.01739 ? 123 LEU A N   1 
ATOM   928  C  CA  . LEU A 1 125 ? 15.49731 -24.55071 -10.70677 1.000 18.29123 ? 123 LEU A CA  1 
ATOM   929  C  C   . LEU A 1 125 ? 14.36444 -24.13150 -9.77843  1.000 18.27308 ? 123 LEU A C   1 
ATOM   930  O  O   . LEU A 1 125 ? 14.45663 -24.25169 -8.54806  1.000 16.81801 ? 123 LEU A O   1 
ATOM   931  C  CB  . LEU A 1 125 ? 16.44876 -25.54467 -10.02562 1.000 17.51804 ? 123 LEU A CB  1 
ATOM   932  C  CG  . LEU A 1 125 ? 15.90718 -26.95697 -9.79071  1.000 18.52525 ? 123 LEU A CG  1 
ATOM   933  C  CD1 . LEU A 1 125 ? 15.73350 -27.72128 -11.10614 1.000 16.99579 ? 123 LEU A CD1 1 
ATOM   934  C  CD2 . LEU A 1 125 ? 16.81917 -27.71675 -8.82937  1.000 18.83647 ? 123 LEU A CD2 1 
ATOM   935  N  N   . PRO A 1 126 ? 13.26564 -23.63507 -10.34204 1.000 17.41682 ? 124 PRO A N   1 
ATOM   936  C  CA  . PRO A 1 126 ? 12.14420 -23.17980 -9.51546  1.000 17.71144 ? 124 PRO A CA  1 
ATOM   937  C  C   . PRO A 1 126 ? 11.48644 -24.34950 -8.81496  1.000 20.15781 ? 124 PRO A C   1 
ATOM   938  O  O   . PRO A 1 126 ? 11.53696 -25.48636 -9.29315  1.000 17.47627 ? 124 PRO A O   1 
ATOM   939  C  CB  . PRO A 1 126 ? 11.18592 -22.53827 -10.53538 1.000 20.65423 ? 124 PRO A CB  1 
ATOM   940  C  CG  . PRO A 1 126 ? 12.01994 -22.26559 -11.75581 1.000 22.60518 ? 124 PRO A CG  1 
ATOM   941  C  CD  . PRO A 1 126 ? 13.04900 -23.37911 -11.77597 1.000 17.96006 ? 124 PRO A CD  1 
ATOM   942  N  N   . TYR A 1 127 ? 10.87626 -24.07256 -7.65809  1.000 19.12229 ? 125 TYR A N   1 
ATOM   943  C  CA  . TYR A 1 127 ? 10.14749 -25.10833 -6.92244  1.000 18.44414 ? 125 TYR A CA  1 
ATOM   944  C  C   . TYR A 1 127 ? 11.02147 -26.35595 -6.73722  1.000 17.77794 ? 125 TYR A C   1 
ATOM   945  O  O   . TYR A 1 127 ? 10.61866 -27.47644 -7.05297  1.000 18.13958 ? 125 TYR A O   1 
ATOM   946  C  CB  . TYR A 1 127 ? 8.84866  -25.45733 -7.65913  1.000 18.91051 ? 125 TYR A CB  1 
ATOM   947  C  CG  . TYR A 1 127 ? 7.81297  -26.19607 -6.83637  1.000 20.79761 ? 125 TYR A CG  1 
ATOM   948  C  CD1 . TYR A 1 127 ? 7.10317  -25.53678 -5.83545  1.000 21.93177 ? 125 TYR A CD1 1 
ATOM   949  C  CD2 . TYR A 1 127 ? 7.52881  -27.53974 -7.06491  1.000 20.65302 ? 125 TYR A CD2 1 
ATOM   950  C  CE1 . TYR A 1 127 ? 6.13650  -26.19606 -5.07953  1.000 24.91611 ? 125 TYR A CE1 1 
ATOM   951  C  CE2 . TYR A 1 127 ? 6.56150  -28.21688 -6.30682  1.000 21.35761 ? 125 TYR A CE2 1 
ATOM   952  C  CZ  . TYR A 1 127 ? 5.87600  -27.53278 -5.31083  1.000 24.61718 ? 125 TYR A CZ  1 
ATOM   953  O  OH  . TYR A 1 127 ? 4.92107  -28.17631 -4.55457  1.000 22.72736 ? 125 TYR A OH  1 
ATOM   954  N  N   . ALA A 1 128 ? 12.24288 -26.14973 -6.24621  1.000 17.43072 ? 126 ALA A N   1 
ATOM   955  C  CA  . ALA A 1 128 ? 13.24448 -27.21254 -6.26871  1.000 18.53328 ? 126 ALA A CA  1 
ATOM   956  C  C   . ALA A 1 128 ? 12.91925 -28.33967 -5.29488  1.000 18.34614 ? 126 ALA A C   1 
ATOM   957  O  O   . ALA A 1 128 ? 12.49455 -28.11185 -4.15361  1.000 17.70929 ? 126 ALA A O   1 
ATOM   958  C  CB  . ALA A 1 128 ? 14.62488 -26.66045 -5.94579  1.000 18.79439 ? 126 ALA A CB  1 
ATOM   959  N  N   . PHE A 1 129 ? 13.13909 -29.56524 -5.76123  1.000 16.32809 ? 127 PHE A N   1 
ATOM   960  C  CA  . PHE A 1 129 ? 13.08325 -30.73885 -4.90438  1.000 18.40359 ? 127 PHE A CA  1 
ATOM   961  C  C   . PHE A 1 129 ? 14.20690 -30.68143 -3.87850  1.000 20.68333 ? 127 PHE A C   1 
ATOM   962  O  O   . PHE A 1 129 ? 15.35471 -30.39374 -4.22798  1.000 19.13122 ? 127 PHE A O   1 
ATOM   963  C  CB  . PHE A 1 129 ? 13.21912 -31.99750 -5.75901  1.000 19.30759 ? 127 PHE A CB  1 
ATOM   964  C  CG  . PHE A 1 129 ? 13.15704 -33.27345 -4.97035  1.000 20.65390 ? 127 PHE A CG  1 
ATOM   965  C  CD1 . PHE A 1 129 ? 11.94195 -33.81462 -4.58662  1.000 21.64813 ? 127 PHE A CD1 1 
ATOM   966  C  CD2 . PHE A 1 129 ? 14.32797 -33.93407 -4.61572  1.000 20.55991 ? 127 PHE A CD2 1 
ATOM   967  C  CE1 . PHE A 1 129 ? 11.88786 -34.99479 -3.85737  1.000 24.26104 ? 127 PHE A CE1 1 
ATOM   968  C  CE2 . PHE A 1 129 ? 14.28585 -35.09965 -3.88517  1.000 18.42132 ? 127 PHE A CE2 1 
ATOM   969  C  CZ  . PHE A 1 129 ? 13.07512 -35.64511 -3.50672  1.000 20.75523 ? 127 PHE A CZ  1 
ATOM   970  N  N   . THR A 1 130 ? 13.88210 -30.95681 -2.61330  1.000 18.72043 ? 128 THR A N   1 
ATOM   971  C  CA  . THR A 1 130 ? 14.85386 -30.96171 -1.51975  1.000 20.43728 ? 128 THR A CA  1 
ATOM   972  C  C   . THR A 1 130 ? 14.65060 -32.21398 -0.67493  1.000 23.59302 ? 128 THR A C   1 
ATOM   973  O  O   . THR A 1 130 ? 13.74429 -33.01493 -0.92202  1.000 23.05578 ? 128 THR A O   1 
ATOM   974  C  CB  . THR A 1 130 ? 14.71260 -29.73381 -0.60929  1.000 26.37149 ? 128 THR A CB  1 
ATOM   975  O  OG1 . THR A 1 130 ? 13.57959 -29.92747 0.25099   1.000 26.28657 ? 128 THR A OG1 1 
ATOM   976  C  CG2 . THR A 1 130 ? 14.51757 -28.47070 -1.41646  1.000 24.95298 ? 128 THR A CG2 1 
ATOM   977  N  N   . GLU A 1 131 ? 15.49352 -32.36653 0.35243   1.000 21.90517 ? 129 GLU A N   1 
ATOM   978  C  CA  . GLU A 1 131 ? 15.44378 -33.52115 1.25162   1.000 24.48207 ? 129 GLU A CA  1 
ATOM   979  C  C   . GLU A 1 131 ? 14.29085 -33.46173 2.25520   1.000 29.18552 ? 129 GLU A C   1 
ATOM   980  O  O   . GLU A 1 131 ? 14.08805 -34.42758 3.00432   1.000 26.00431 ? 129 GLU A O   1 
ATOM   981  C  CB  . GLU A 1 131 ? 16.77753 -33.63420 2.00804   1.000 26.26308 ? 129 GLU A CB  1 
ATOM   982  C  CG  . GLU A 1 131 ? 16.84844 -32.72640 3.22000   1.000 32.50834 ? 129 GLU A CG  1 
ATOM   983  C  CD  . GLU A 1 131 ? 17.32053 -31.33443 2.87819   1.000 37.91498 ? 129 GLU A CD  1 
ATOM   984  O  OE1 . GLU A 1 131 ? 17.44432 -31.02480 1.67322   1.000 40.15634 ? 129 GLU A OE1 1 
ATOM   985  O  OE2 . GLU A 1 131 ? 17.52348 -30.52803 3.81312   1.000 46.64426 ? 129 GLU A OE2 1 
ATOM   986  N  N   . LYS A 1 132 ? 13.52803 -32.37016 2.26310   1.000 30.10409 ? 130 LYS A N   1 
ATOM   987  C  CA  . LYS A 1 132 ? 12.49452 -32.06634 3.25443   1.000 32.32312 ? 130 LYS A CA  1 
ATOM   988  C  C   . LYS A 1 132 ? 11.61819 -33.24923 3.66051   1.000 32.62985 ? 130 LYS A C   1 
ATOM   989  O  O   . LYS A 1 132 ? 11.32219 -33.42308 4.84935   1.000 32.10037 ? 130 LYS A O   1 
ATOM   990  C  CB  . LYS A 1 132 ? 11.61390 -30.95306 2.69670   1.000 33.46783 ? 130 LYS A CB  1 
ATOM   991  C  CG  . LYS A 1 132 ? 10.82566 -30.14604 3.68471   1.000 44.38358 ? 130 LYS A CG  1 
ATOM   992  C  CD  . LYS A 1 132 ? 9.71248  -29.38928 2.94515   1.000 42.33551 ? 130 LYS A CD  1 
ATOM   993  C  CE  . LYS A 1 132 ? 10.02414 -29.25054 1.45574   1.000 35.79597 ? 130 LYS A CE  1 
ATOM   994  N  NZ  . LYS A 1 132 ? 9.17609  -28.23891 0.76655   1.000 45.57958 ? 130 LYS A NZ  1 
ATOM   995  N  N   . ASP A 1 133 ? 11.18348 -34.06230 2.69279   1.000 29.76644 ? 131 ASP A N   1 
ATOM   996  C  CA  . ASP A 1 133 ? 10.19224 -35.10178 2.94661   1.000 29.26517 ? 131 ASP A CA  1 
ATOM   997  C  C   . ASP A 1 133 ? 10.78844 -36.50205 3.00818   1.000 30.14945 ? 131 ASP A C   1 
ATOM   998  O  O   . ASP A 1 133 ? 10.03642 -37.48183 3.10753   1.000 26.22870 ? 131 ASP A O   1 
ATOM   999  C  CB  . ASP A 1 133 ? 9.08935  -35.05524 1.88335   1.000 27.22984 ? 131 ASP A CB  1 
ATOM   1000 C  CG  . ASP A 1 133 ? 8.28871  -33.75980 1.93208   1.000 32.18408 ? 131 ASP A CG  1 
ATOM   1001 O  OD1 . ASP A 1 133 ? 7.89875  -33.34229 3.04530   1.000 32.06941 ? 131 ASP A OD1 1 
ATOM   1002 O  OD2 . ASP A 1 133 ? 8.02907  -33.17147 0.85847   1.000 28.90072 ? 131 ASP A OD2 1 
ATOM   1003 N  N   . LEU A 1 134 ? 12.10938 -36.62655 2.95179   1.000 27.03727 ? 132 LEU A N   1 
ATOM   1004 C  CA  . LEU A 1 134 ? 12.71599 -37.94708 2.96027   1.000 28.05203 ? 132 LEU A CA  1 
ATOM   1005 C  C   . LEU A 1 134 ? 12.69291 -38.52943 4.36850   1.000 35.67032 ? 132 LEU A C   1 
ATOM   1006 O  O   . LEU A 1 134 ? 12.68963 -37.78803 5.35834   1.000 34.94571 ? 132 LEU A O   1 
ATOM   1007 C  CB  . LEU A 1 134 ? 14.14128 -37.88432 2.44566   1.000 28.17356 ? 132 LEU A CB  1 
ATOM   1008 C  CG  . LEU A 1 134 ? 14.30092 -37.39402 1.01436   1.000 26.44005 ? 132 LEU A CG  1 
ATOM   1009 C  CD1 . LEU A 1 134 ? 15.78820 -37.38788 0.70553   1.000 25.66945 ? 132 LEU A CD1 1 
ATOM   1010 C  CD2 . LEU A 1 134 ? 13.50834 -38.26261 0.03892   1.000 23.31578 ? 132 LEU A CD2 1 
ATOM   1011 O  OXT . LEU A 1 134 ? 12.67736 -39.74969 4.53712   1.000 38.35624 ? 132 LEU A OXT 1 
ATOM   1012 N  N   . ALA B 1 4   ? 52.37452 -56.37784 -5.84132  1.000 43.93816 ? 2   ALA B N   1 
ATOM   1013 C  CA  . ALA B 1 4   ? 51.91725 -54.99565 -5.94311  1.000 40.68753 ? 2   ALA B CA  1 
ATOM   1014 C  C   . ALA B 1 4   ? 52.29635 -54.17276 -4.70381  1.000 38.92156 ? 2   ALA B C   1 
ATOM   1015 O  O   . ALA B 1 4   ? 52.10374 -54.59114 -3.55833  1.000 42.92299 ? 2   ALA B O   1 
ATOM   1016 C  CB  . ALA B 1 4   ? 50.40241 -54.94923 -6.17493  1.000 40.40664 ? 2   ALA B CB  1 
ATOM   1017 N  N   . GLU B 1 5   ? 52.85700 -52.99887 -4.96673  1.000 35.90051 ? 3   GLU B N   1 
ATOM   1018 C  CA  . GLU B 1 5   ? 53.20363 -52.04810 -3.92164  1.000 31.82568 ? 3   GLU B CA  1 
ATOM   1019 C  C   . GLU B 1 5   ? 51.95408 -51.51189 -3.23221  1.000 31.17144 ? 3   GLU B C   1 
ATOM   1020 O  O   . GLU B 1 5   ? 50.94398 -51.21975 -3.88191  1.000 33.83198 ? 3   GLU B O   1 
ATOM   1021 C  CB  . GLU B 1 5   ? 53.99485 -50.90718 -4.55130  1.000 30.14686 ? 3   GLU B CB  1 
ATOM   1022 C  CG  . GLU B 1 5   ? 54.21265 -49.70221 -3.69746  1.000 30.73162 ? 3   GLU B CG  1 
ATOM   1023 C  CD  . GLU B 1 5   ? 55.24463 -48.80484 -4.31683  1.000 35.66455 ? 3   GLU B CD  1 
ATOM   1024 O  OE1 . GLU B 1 5   ? 54.95192 -48.19979 -5.37168  1.000 34.03786 ? 3   GLU B OE1 1 
ATOM   1025 O  OE2 . GLU B 1 5   ? 56.35692 -48.71267 -3.75965  1.000 32.34582 ? 3   GLU B OE2 1 
ATOM   1026 N  N   . LEU B 1 6   ? 52.02728 -51.36952 -1.90941  1.000 30.38037 ? 4   LEU B N   1 
ATOM   1027 C  CA  . LEU B 1 6   ? 50.93548 -50.80173 -1.11975  1.000 30.45207 ? 4   LEU B CA  1 
ATOM   1028 C  C   . LEU B 1 6   ? 51.54111 -49.95204 -0.01134  1.000 30.43109 ? 4   LEU B C   1 
ATOM   1029 O  O   . LEU B 1 6   ? 52.20562 -50.48103 0.88520   1.000 29.26359 ? 4   LEU B O   1 
ATOM   1030 C  CB  . LEU B 1 6   ? 50.03354 -51.89121 -0.54012  1.000 31.31000 ? 4   LEU B CB  1 
ATOM   1031 C  CG  . LEU B 1 6   ? 48.83711 -51.42885 0.31203   1.000 30.46412 ? 4   LEU B CG  1 
ATOM   1032 C  CD1 . LEU B 1 6   ? 47.91700 -50.48105 -0.44691  1.000 29.42756 ? 4   LEU B CD1 1 
ATOM   1033 C  CD2 . LEU B 1 6   ? 48.05742 -52.62422 0.83349   1.000 32.33208 ? 4   LEU B CD2 1 
ATOM   1034 N  N   . LYS B 1 7   ? 51.31631 -48.64327 -0.06644  1.000 28.24258 ? 5   LYS B N   1 
ATOM   1035 C  CA  . LYS B 1 7   ? 51.83768 -47.72669 0.93788   1.000 25.59795 ? 5   LYS B CA  1 
ATOM   1036 C  C   . LYS B 1 7   ? 50.78407 -47.41401 1.99168   1.000 31.15644 ? 5   LYS B C   1 
ATOM   1037 O  O   . LYS B 1 7   ? 49.59599 -47.27792 1.68175   1.000 27.94871 ? 5   LYS B O   1 
ATOM   1038 C  CB  . LYS B 1 7   ? 52.35321 -46.43858 0.29219   1.000 25.61346 ? 5   LYS B CB  1 
ATOM   1039 C  CG  . LYS B 1 7   ? 53.36171 -46.70456 -0.82106  1.000 28.82311 ? 5   LYS B CG  1 
ATOM   1040 C  CD  . LYS B 1 7   ? 54.24434 -45.51410 -1.09237  1.000 30.15257 ? 5   LYS B CD  1 
ATOM   1041 C  CE  . LYS B 1 7   ? 55.07037 -45.74774 -2.35154  1.000 37.01706 ? 5   LYS B CE  1 
ATOM   1042 N  NZ  . LYS B 1 7   ? 56.01615 -44.63617 -2.64285  1.000 38.09136 ? 5   LYS B NZ  1 
ATOM   1043 N  N   . GLN B 1 8   ? 51.22504 -47.31605 3.25019   1.000 28.53079 ? 6   GLN B N   1 
ATOM   1044 C  CA  . GLN B 1 8   ? 50.27697 -47.05541 4.32719   1.000 31.28299 ? 6   GLN B CA  1 
ATOM   1045 C  C   . GLN B 1 8   ? 49.59139 -45.70588 4.14325   1.000 28.86407 ? 6   GLN B C   1 
ATOM   1046 O  O   . GLN B 1 8   ? 48.41876 -45.55116 4.51050   1.000 28.50813 ? 6   GLN B O   1 
ATOM   1047 C  CB  . GLN B 1 8   ? 50.97993 -47.12265 5.68628   1.000 34.26719 ? 6   GLN B CB  1 
ATOM   1048 C  CG  . GLN B 1 8   ? 50.02465 -46.91022 6.83404   1.000 32.24504 ? 6   GLN B CG  1 
ATOM   1049 C  CD  . GLN B 1 8   ? 49.07393 -48.07930 6.99906   1.000 36.51142 ? 6   GLN B CD  1 
ATOM   1050 O  OE1 . GLN B 1 8   ? 49.44800 -49.23616 6.77728   1.000 39.83107 ? 6   GLN B OE1 1 
ATOM   1051 N  NE2 . GLN B 1 8   ? 47.81839 -47.78290 7.33365   1.000 32.25010 ? 6   GLN B NE2 1 
ATOM   1052 N  N   . GLU B 1 9   ? 50.30163 -44.73207 3.56204   1.000 27.92634 ? 7   GLU B N   1 
ATOM   1053 C  CA  . GLU B 1 9   ? 49.70705 -43.42932 3.25998   1.000 31.03700 ? 7   GLU B CA  1 
ATOM   1054 C  C   . GLU B 1 9   ? 48.44280 -43.56668 2.42759   1.000 30.14780 ? 7   GLU B C   1 
ATOM   1055 O  O   . GLU B 1 9   ? 47.48162 -42.80679 2.61190   1.000 28.58163 ? 7   GLU B O   1 
ATOM   1056 C  CB  . GLU B 1 9   ? 50.68830 -42.55172 2.49776   1.000 34.81581 ? 7   GLU B CB  1 
ATOM   1057 C  CG  . GLU B 1 9   ? 50.26062 -41.10172 2.43152   1.000 41.00742 ? 7   GLU B CG  1 
ATOM   1058 C  CD  . GLU B 1 9   ? 51.32312 -40.22045 1.82046   1.000 50.53240 ? 7   GLU B CD  1 
ATOM   1059 O  OE1 . GLU B 1 9   ? 52.46861 -40.70208 1.68888   1.000 51.50729 ? 7   GLU B OE1 1 
ATOM   1060 O  OE2 . GLU B 1 9   ? 51.01060 -39.05994 1.45394   1.000 51.55025 ? 7   GLU B OE2 1 
ATOM   1061 N  N   . TRP B 1 10  ? 48.44488 -44.50849 1.48104   1.000 26.49443 ? 8   TRP B N   1 
ATOM   1062 C  CA  . TRP B 1 10  ? 47.28971 -44.70813 0.60955   1.000 22.93288 ? 8   TRP B CA  1 
ATOM   1063 C  C   . TRP B 1 10  ? 46.10865 -45.27075 1.38909   1.000 27.79352 ? 8   TRP B C   1 
ATOM   1064 O  O   . TRP B 1 10  ? 44.96398 -44.83033 1.21298   1.000 24.54158 ? 8   TRP B O   1 
ATOM   1065 C  CB  . TRP B 1 10  ? 47.66137 -45.65629 -0.52797  1.000 24.44043 ? 8   TRP B CB  1 
ATOM   1066 C  CG  . TRP B 1 10  ? 48.81601 -45.21970 -1.36941  1.000 23.19706 ? 8   TRP B CG  1 
ATOM   1067 C  CD1 . TRP B 1 10  ? 49.39830 -43.98286 -1.40553  1.000 21.36904 ? 8   TRP B CD1 1 
ATOM   1068 C  CD2 . TRP B 1 10  ? 49.53728 -46.03186 -2.29887  1.000 23.61135 ? 8   TRP B CD2 1 
ATOM   1069 N  NE1 . TRP B 1 10  ? 50.44188 -43.97835 -2.30682  1.000 24.40285 ? 8   TRP B NE1 1 
ATOM   1070 C  CE2 . TRP B 1 10  ? 50.54587 -45.22448 -2.86865  1.000 26.43001 ? 8   TRP B CE2 1 
ATOM   1071 C  CE3 . TRP B 1 10  ? 49.42748 -47.36692 -2.70690  1.000 26.38613 ? 8   TRP B CE3 1 
ATOM   1072 C  CZ2 . TRP B 1 10  ? 51.44429 -45.71000 -3.82269  1.000 27.51702 ? 8   TRP B CZ2 1 
ATOM   1073 C  CZ3 . TRP B 1 10  ? 50.31794 -47.84512 -3.65443  1.000 27.66467 ? 8   TRP B CZ3 1 
ATOM   1074 C  CH2 . TRP B 1 10  ? 51.31043 -47.01815 -4.20376  1.000 28.88653 ? 8   TRP B CH2 1 
ATOM   1075 N  N   . ILE B 1 11  ? 46.36777 -46.28245 2.22381   1.000 25.61611 ? 9   ILE B N   1 
ATOM   1076 C  CA  . ILE B 1 11  ? 45.34192 -46.82369 3.10585   1.000 23.88109 ? 9   ILE B CA  1 
ATOM   1077 C  C   . ILE B 1 11  ? 44.79219 -45.73001 4.00883   1.000 26.29702 ? 9   ILE B C   1 
ATOM   1078 O  O   . ILE B 1 11  ? 43.57248 -45.57040 4.15076   1.000 23.65726 ? 9   ILE B O   1 
ATOM   1079 C  CB  . ILE B 1 11  ? 45.91482 -48.00365 3.91586   1.000 25.25081 ? 9   ILE B CB  1 
ATOM   1080 C  CG1 . ILE B 1 11  ? 46.39521 -49.10520 2.96733   1.000 29.47001 ? 9   ILE B CG1 1 
ATOM   1081 C  CG2 . ILE B 1 11  ? 44.89049 -48.55158 4.89989   1.000 26.39263 ? 9   ILE B CG2 1 
ATOM   1082 C  CD1 . ILE B 1 11  ? 47.00271 -50.29600 3.67733   1.000 33.30190 ? 9   ILE B CD1 1 
ATOM   1083 N  N   . ASN B 1 12  ? 45.69105 -44.95917 4.63163   1.000 23.20812 ? 10  ASN B N   1 
ATOM   1084 C  CA  . ASN B 1 12  ? 45.27761 -43.86029 5.49852   1.000 25.78334 ? 10  ASN B CA  1 
ATOM   1085 C  C   . ASN B 1 12  ? 44.39990 -42.86600 4.74807   1.000 24.76583 ? 10  ASN B C   1 
ATOM   1086 O  O   . ASN B 1 12  ? 43.38670 -42.39724 5.27963   1.000 23.67854 ? 10  ASN B O   1 
ATOM   1087 C  CB  . ASN B 1 12  ? 46.50138 -43.13979 6.05354   1.000 28.24422 ? 10  ASN B CB  1 
ATOM   1088 C  CG  . ASN B 1 12  ? 47.29332 -43.99077 7.02693   1.000 30.76728 ? 10  ASN B CG  1 
ATOM   1089 O  OD1 . ASN B 1 12  ? 46.82467 -45.03207 7.49058   1.000 27.11773 ? 10  ASN B OD1 1 
ATOM   1090 N  ND2 . ASN B 1 12  ? 48.50512 -43.54747 7.33890   1.000 38.18981 ? 10  ASN B ND2 1 
ATOM   1091 N  N   . THR B 1 13  ? 44.77927 -42.53056 3.51456   1.000 23.38651 ? 11  THR B N   1 
ATOM   1092 C  CA  . THR B 1 13  ? 43.99207 -41.57514 2.74324   1.000 24.87385 ? 11  THR B CA  1 
ATOM   1093 C  C   . THR B 1 13  ? 42.56461 -42.07145 2.53707   1.000 24.04317 ? 11  THR B C   1 
ATOM   1094 O  O   . THR B 1 13  ? 41.60381 -41.30798 2.72002   1.000 23.30540 ? 11  THR B O   1 
ATOM   1095 C  CB  . THR B 1 13  ? 44.67175 -41.29896 1.40525   1.000 26.90529 ? 11  THR B CB  1 
ATOM   1096 O  OG1 . THR B 1 13  ? 45.89473 -40.58683 1.64044   1.000 27.20742 ? 11  THR B OG1 1 
ATOM   1097 C  CG2 . THR B 1 13  ? 43.76244 -40.45640 0.52338   1.000 21.80852 ? 11  THR B CG2 1 
ATOM   1098 N  N   . ALA B 1 14  ? 42.39887 -43.35716 2.19575   1.000 22.05114 ? 12  ALA B N   1 
ATOM   1099 C  CA  . ALA B 1 14  ? 41.04764 -43.86885 1.95986   1.000 19.69614 ? 12  ALA B CA  1 
ATOM   1100 C  C   . ALA B 1 14  ? 40.25267 -43.97123 3.25782   1.000 24.25232 ? 12  ALA B C   1 
ATOM   1101 O  O   . ALA B 1 14  ? 39.06271 -43.63961 3.28800   1.000 21.58746 ? 12  ALA B O   1 
ATOM   1102 C  CB  . ALA B 1 14  ? 41.10356 -45.22602 1.24331   1.000 21.56243 ? 12  ALA B CB  1 
ATOM   1103 N  N   . ILE B 1 15  ? 40.87498 -44.44338 4.34569   1.000 21.63645 ? 13  ILE B N   1 
ATOM   1104 C  CA  . ILE B 1 15  ? 40.13615 -44.54789 5.60025   1.000 22.12413 ? 13  ILE B CA  1 
ATOM   1105 C  C   . ILE B 1 15  ? 39.80470 -43.18103 6.17584   1.000 20.83647 ? 13  ILE B C   1 
ATOM   1106 O  O   . ILE B 1 15  ? 38.70693 -42.98255 6.71283   1.000 24.54397 ? 13  ILE B O   1 
ATOM   1107 C  CB  . ILE B 1 15  ? 40.88927 -45.42661 6.61745   1.000 23.72046 ? 13  ILE B CB  1 
ATOM   1108 C  CG1 . ILE B 1 15  ? 41.22108 -46.77688 5.97882   1.000 26.70072 ? 13  ILE B CG1 1 
ATOM   1109 C  CG2 . ILE B 1 15  ? 40.12034 -45.52058 7.93298   1.000 26.18765 ? 13  ILE B CG2 1 
ATOM   1110 C  CD1 . ILE B 1 15  ? 41.79017 -47.79792 6.95512   1.000 29.79976 ? 13  ILE B CD1 1 
ATOM   1111 N  N   . GLU B 1 16  ? 40.73227 -42.22211 6.08911   1.000 23.35897 ? 14  GLU B N   1 
ATOM   1112 C  CA  . GLU B 1 16  ? 40.44997 -40.89277 6.62214   1.000 22.51236 ? 14  GLU B CA  1 
ATOM   1113 C  C   . GLU B 1 16  ? 39.27428 -40.25038 5.90509   1.000 24.61707 ? 14  GLU B C   1 
ATOM   1114 O  O   . GLU B 1 16  ? 38.52783 -39.47871 6.51244   1.000 23.35274 ? 14  GLU B O   1 
ATOM   1115 C  CB  . GLU B 1 16  ? 41.67865 -39.99489 6.52712   1.000 23.69912 ? 14  GLU B CB  1 
ATOM   1116 C  CG  . GLU B 1 16  ? 42.78272 -40.40871 7.48663   1.000 26.86155 ? 14  GLU B CG  1 
ATOM   1117 C  CD  . GLU B 1 16  ? 44.13241 -39.77304 7.17585   1.000 32.90082 ? 14  GLU B CD  1 
ATOM   1118 O  OE1 . GLU B 1 16  ? 44.20898 -38.89840 6.28296   1.000 33.77289 ? 14  GLU B OE1 1 
ATOM   1119 O  OE2 . GLU B 1 16  ? 45.13190 -40.17076 7.82392   1.000 34.82639 ? 14  GLU B OE2 1 
ATOM   1120 N  N   . ALA B 1 17  ? 39.09122 -40.57290 4.62717   1.000 23.32150 ? 15  ALA B N   1 
ATOM   1121 C  CA  . ALA B 1 17  ? 37.96372 -40.05223 3.86171   1.000 19.69438 ? 15  ALA B CA  1 
ATOM   1122 C  C   . ALA B 1 17  ? 36.61279 -40.47639 4.42818   1.000 25.58275 ? 15  ALA B C   1 
ATOM   1123 O  O   . ALA B 1 17  ? 35.60285 -39.80160 4.17151   1.000 21.80142 ? 15  ALA B O   1 
ATOM   1124 C  CB  . ALA B 1 17  ? 38.09406 -40.51142 2.40495   1.000 21.45347 ? 15  ALA B CB  1 
ATOM   1125 N  N   . LEU B 1 18  ? 36.55479 -41.58371 5.17616   1.000 24.68174 ? 16  LEU B N   1 
ATOM   1126 C  CA  . LEU B 1 18  ? 35.26583 -42.04229 5.68264   1.000 23.52624 ? 16  LEU B CA  1 
ATOM   1127 C  C   . LEU B 1 18  ? 34.63759 -40.98491 6.58105   1.000 30.66488 ? 16  LEU B C   1 
ATOM   1128 O  O   . LEU B 1 18  ? 33.42262 -40.75049 6.53251   1.000 31.01266 ? 16  LEU B O   1 
ATOM   1129 C  CB  . LEU B 1 18  ? 35.44422 -43.36078 6.42983   1.000 25.93570 ? 16  LEU B CB  1 
ATOM   1130 C  CG  . LEU B 1 18  ? 35.90178 -44.52752 5.55591   1.000 24.26949 ? 16  LEU B CG  1 
ATOM   1131 C  CD1 . LEU B 1 18  ? 36.23514 -45.74259 6.41702   1.000 25.26086 ? 16  LEU B CD1 1 
ATOM   1132 C  CD2 . LEU B 1 18  ? 34.88932 -44.88675 4.45702   1.000 21.41516 ? 16  LEU B CD2 1 
ATOM   1133 N  N   . ASP B 1 19  ? 35.45957 -40.28678 7.36310   1.000 24.87047 ? 17  ASP B N   1 
ATOM   1134 C  CA  . ASP B 1 19  ? 34.93754 -39.24560 8.23988   1.000 29.86143 ? 17  ASP B CA  1 
ATOM   1135 C  C   . ASP B 1 19  ? 34.54171 -37.97678 7.49111   1.000 29.33484 ? 17  ASP B C   1 
ATOM   1136 O  O   . ASP B 1 19  ? 33.93480 -37.09051 8.09762   1.000 30.07755 ? 17  ASP B O   1 
ATOM   1137 C  CB  . ASP B 1 19  ? 35.98646 -38.90839 9.30533   1.000 27.88517 ? 17  ASP B CB  1 
ATOM   1138 C  CG  . ASP B 1 19  ? 35.83364 -39.74026 10.56649  1.000 38.89273 ? 17  ASP B CG  1 
ATOM   1139 O  OD1 . ASP B 1 19  ? 34.80231 -40.43219 10.72673  1.000 41.77395 ? 17  ASP B OD1 1 
ATOM   1140 O  OD2 . ASP B 1 19  ? 36.76347 -39.70886 11.39667  1.000 45.16829 ? 17  ASP B OD2 1 
ATOM   1141 N  N   . LYS B 1 20  ? 34.86329 -37.87006 6.20176   1.000 24.84306 ? 18  LYS B N   1 
ATOM   1142 C  CA  . LYS B 1 20  ? 34.66065 -36.64812 5.43350   1.000 22.51549 ? 18  LYS B CA  1 
ATOM   1143 C  C   . LYS B 1 20  ? 33.51788 -36.75749 4.42885   1.000 21.68579 ? 18  LYS B C   1 
ATOM   1144 O  O   . LYS B 1 20  ? 33.23550 -35.77482 3.72776   1.000 21.99264 ? 18  LYS B O   1 
ATOM   1145 C  CB  . LYS B 1 20  ? 35.94458 -36.27130 4.67366   1.000 25.89308 ? 18  LYS B CB  1 
ATOM   1146 C  CG  . LYS B 1 20  ? 37.20546 -36.05690 5.50360   1.000 26.17044 ? 18  LYS B CG  1 
ATOM   1147 C  CD  . LYS B 1 20  ? 38.42871 -36.05921 4.58576   1.000 29.25478 ? 18  LYS B CD  1 
ATOM   1148 C  CE  . LYS B 1 20  ? 39.52573 -35.10519 5.03833   1.000 35.90948 ? 18  LYS B CE  1 
ATOM   1149 N  NZ  . LYS B 1 20  ? 40.28977 -34.53017 3.87713   1.000 33.40674 ? 18  LYS B NZ  1 
ATOM   1150 N  N   . ALA B 1 21  ? 32.86099 -37.91234 4.33875   1.000 21.55331 ? 19  ALA B N   1 
ATOM   1151 C  CA  . ALA B 1 21  ? 31.88035 -38.14056 3.28001   1.000 23.08833 ? 19  ALA B CA  1 
ATOM   1152 C  C   . ALA B 1 21  ? 30.63373 -37.28948 3.49297   1.000 22.94765 ? 19  ALA B C   1 
ATOM   1153 O  O   . ALA B 1 21  ? 30.30288 -36.88446 4.61645   1.000 21.10812 ? 19  ALA B O   1 
ATOM   1154 C  CB  . ALA B 1 21  ? 31.49697 -39.62030 3.21253   1.000 20.23577 ? 19  ALA B CB  1 
ATOM   1155 N  N   . TYR B 1 22  ? 29.94410 -36.99826 2.38898   1.000 18.09975 ? 20  TYR B N   1 
ATOM   1156 C  CA  . TYR B 1 22  ? 28.67686 -36.27117 2.44687   1.000 18.81223 ? 20  TYR B CA  1 
ATOM   1157 C  C   . TYR B 1 22  ? 27.57714 -37.30562 2.22460   1.000 19.10971 ? 20  TYR B C   1 
ATOM   1158 O  O   . TYR B 1 22  ? 27.20588 -37.62638 1.08888   1.000 17.02519 ? 20  TYR B O   1 
ATOM   1159 C  CB  . TYR B 1 22  ? 28.62867 -35.12722 1.43675   1.000 17.32351 ? 20  TYR B CB  1 
ATOM   1160 C  CG  . TYR B 1 22  ? 27.30695 -34.39793 1.46145   1.000 18.56307 ? 20  TYR B CG  1 
ATOM   1161 C  CD1 . TYR B 1 22  ? 27.00388 -33.51397 2.49038   1.000 17.67403 ? 20  TYR B CD1 1 
ATOM   1162 C  CD2 . TYR B 1 22  ? 26.37076 -34.57887 0.45177   1.000 16.63619 ? 20  TYR B CD2 1 
ATOM   1163 C  CE1 . TYR B 1 22  ? 25.79981 -32.84127 2.53563   1.000 17.66781 ? 20  TYR B CE1 1 
ATOM   1164 C  CE2 . TYR B 1 22  ? 25.16150 -33.91694 0.48405   1.000 18.14614 ? 20  TYR B CE2 1 
ATOM   1165 C  CZ  . TYR B 1 22  ? 24.87713 -33.04334 1.52939   1.000 16.85054 ? 20  TYR B CZ  1 
ATOM   1166 O  OH  . TYR B 1 22  ? 23.66469 -32.38944 1.55267   1.000 20.21140 ? 20  TYR B OH  1 
ATOM   1167 N  N   . VAL B 1 23  ? 27.07997 -37.85996 3.32972   1.000 18.03266 ? 21  VAL B N   1 
ATOM   1168 C  CA  . VAL B 1 23  ? 26.16074 -38.99103 3.28383   1.000 18.98729 ? 21  VAL B CA  1 
ATOM   1169 C  C   . VAL B 1 23  ? 24.98436 -38.75568 4.22708   1.000 20.43522 ? 21  VAL B C   1 
ATOM   1170 O  O   . VAL B 1 23  ? 24.67412 -39.62732 5.05190   1.000 20.72178 ? 21  VAL B O   1 
ATOM   1171 C  CB  . VAL B 1 23  ? 26.89374 -40.30577 3.60829   1.000 19.67810 ? 21  VAL B CB  1 
ATOM   1172 C  CG1 . VAL B 1 23  ? 27.79201 -40.70556 2.44537   1.000 19.54024 ? 21  VAL B CG1 1 
ATOM   1173 C  CG2 . VAL B 1 23  ? 27.72703 -40.16097 4.88564   1.000 21.66018 ? 21  VAL B CG2 1 
ATOM   1174 N  N   . PRO B 1 24  ? 24.27105 -37.62772 4.12046   1.000 19.22388 ? 22  PRO B N   1 
ATOM   1175 C  CA  . PRO B 1 24  ? 23.14494 -37.39658 5.03817   1.000 20.11199 ? 22  PRO B CA  1 
ATOM   1176 C  C   . PRO B 1 24  ? 21.99349 -38.36649 4.85301   1.000 24.00379 ? 22  PRO B C   1 
ATOM   1177 O  O   . PRO B 1 24  ? 21.14264 -38.45948 5.74593   1.000 24.28191 ? 22  PRO B O   1 
ATOM   1178 C  CB  . PRO B 1 24  ? 22.71783 -35.96081 4.71712   1.000 19.77095 ? 22  PRO B CB  1 
ATOM   1179 C  CG  . PRO B 1 24  ? 23.08826 -35.78030 3.25938   1.000 18.64924 ? 22  PRO B CG  1 
ATOM   1180 C  CD  . PRO B 1 24  ? 24.39267 -36.55104 3.11496   1.000 17.34154 ? 22  PRO B CD  1 
ATOM   1181 N  N   . TYR B 1 25  ? 21.92960 -39.09131 3.73751   1.000 19.48166 ? 23  TYR B N   1 
ATOM   1182 C  CA  . TYR B 1 25  ? 20.80172 -39.97833 3.47911   1.000 20.18555 ? 23  TYR B CA  1 
ATOM   1183 C  C   . TYR B 1 25  ? 21.09956 -41.42932 3.83481   1.000 22.41933 ? 23  TYR B C   1 
ATOM   1184 O  O   . TYR B 1 25  ? 20.28558 -42.06574 4.50468   1.000 26.89461 ? 23  TYR B O   1 
ATOM   1185 C  CB  . TYR B 1 25  ? 20.33746 -39.82721 2.01529   1.000 19.78576 ? 23  TYR B CB  1 
ATOM   1186 C  CG  . TYR B 1 25  ? 20.20746 -38.36325 1.69119   1.000 18.65846 ? 23  TYR B CG  1 
ATOM   1187 C  CD1 . TYR B 1 25  ? 19.31833 -37.56644 2.40435   1.000 22.25401 ? 23  TYR B CD1 1 
ATOM   1188 C  CD2 . TYR B 1 25  ? 20.99924 -37.75457 0.71971   1.000 18.93845 ? 23  TYR B CD2 1 
ATOM   1189 C  CE1 . TYR B 1 25  ? 19.22415 -36.21700 2.16957   1.000 20.66095 ? 23  TYR B CE1 1 
ATOM   1190 C  CE2 . TYR B 1 25  ? 20.90743 -36.39702 0.47622   1.000 18.44302 ? 23  TYR B CE2 1 
ATOM   1191 C  CZ  . TYR B 1 25  ? 20.01638 -35.63270 1.19721   1.000 18.20809 ? 23  TYR B CZ  1 
ATOM   1192 O  OH  . TYR B 1 25  ? 19.91363 -34.27573 0.97494   1.000 21.73043 ? 23  TYR B OH  1 
ATOM   1193 N  N   . SER B 1 26  ? 22.24977 -41.96500 3.43107   1.000 19.43327 ? 24  SER B N   1 
ATOM   1194 C  CA  . SER B 1 26  ? 22.57906 -43.35125 3.75519   1.000 20.25578 ? 24  SER B CA  1 
ATOM   1195 C  C   . SER B 1 26  ? 23.34793 -43.50029 5.05919   1.000 22.75309 ? 24  SER B C   1 
ATOM   1196 O  O   . SER B 1 26  ? 23.31215 -44.58420 5.65471   1.000 23.27764 ? 24  SER B O   1 
ATOM   1197 C  CB  . SER B 1 26  ? 23.40716 -43.99076 2.63924   1.000 18.92450 ? 24  SER B CB  1 
ATOM   1198 O  OG  . SER B 1 26  ? 24.71610 -43.44101 2.61981   1.000 18.80090 ? 24  SER B OG  1 
ATOM   1199 N  N   . HIS B 1 27  ? 24.04000 -42.45536 5.50489   1.000 21.27995 ? 25  HIS B N   1 
ATOM   1200 C  CA  . HIS B 1 27  ? 25.06466 -42.58249 6.55387   1.000 23.72902 ? 25  HIS B CA  1 
ATOM   1201 C  C   . HIS B 1 27  ? 26.00741 -43.75429 6.27121   1.000 26.90016 ? 25  HIS B C   1 
ATOM   1202 O  O   . HIS B 1 27  ? 26.43509 -44.47478 7.18184   1.000 22.71329 ? 25  HIS B O   1 
ATOM   1203 C  CB  . HIS B 1 27  ? 24.43120 -42.72954 7.93921   1.000 24.09162 ? 25  HIS B CB  1 
ATOM   1204 C  CG  . HIS B 1 27  ? 23.65333 -41.53209 8.37640   1.000 27.31599 ? 25  HIS B CG  1 
ATOM   1205 N  ND1 . HIS B 1 27  ? 23.96820 -40.25351 7.97368   1.000 30.72272 ? 25  HIS B ND1 1 
ATOM   1206 C  CD2 . HIS B 1 27  ? 22.59946 -41.41217 9.21827   1.000 34.26018 ? 25  HIS B CD2 1 
ATOM   1207 C  CE1 . HIS B 1 27  ? 23.11724 -39.40049 8.51685   1.000 32.52698 ? 25  HIS B CE1 1 
ATOM   1208 N  NE2 . HIS B 1 27  ? 22.28069 -40.07723 9.28111   1.000 37.25759 ? 25  HIS B NE2 1 
ATOM   1209 N  N   . PHE B 1 28  ? 26.33784 -43.95830 4.99125   1.000 21.17189 ? 26  PHE B N   1 
ATOM   1210 C  CA  . PHE B 1 28  ? 27.20252 -45.05723 4.55648   1.000 19.60362 ? 26  PHE B CA  1 
ATOM   1211 C  C   . PHE B 1 28  ? 28.39960 -44.45288 3.83440   1.000 20.18816 ? 26  PHE B C   1 
ATOM   1212 O  O   . PHE B 1 28  ? 28.38757 -44.31176 2.59917   1.000 20.36209 ? 26  PHE B O   1 
ATOM   1213 C  CB  . PHE B 1 28  ? 26.45570 -46.03530 3.65593   1.000 19.11689 ? 26  PHE B CB  1 
ATOM   1214 C  CG  . PHE B 1 28  ? 27.25307 -47.25626 3.27519   1.000 21.30522 ? 26  PHE B CG  1 
ATOM   1215 C  CD1 . PHE B 1 28  ? 27.38963 -48.32229 4.16856   1.000 24.39711 ? 26  PHE B CD1 1 
ATOM   1216 C  CD2 . PHE B 1 28  ? 27.87131 -47.34303 2.03238   1.000 17.98313 ? 26  PHE B CD2 1 
ATOM   1217 C  CE1 . PHE B 1 28  ? 28.12271 -49.44976 3.81500   1.000 23.70166 ? 26  PHE B CE1 1 
ATOM   1218 C  CE2 . PHE B 1 28  ? 28.60027 -48.45373 1.67248   1.000 20.97310 ? 26  PHE B CE2 1 
ATOM   1219 C  CZ  . PHE B 1 28  ? 28.72930 -49.52311 2.56969   1.000 24.41162 ? 26  PHE B CZ  1 
ATOM   1220 N  N   . PRO B 1 29  ? 29.45745 -44.10567 4.56002   1.000 20.18606 ? 27  PRO B N   1 
ATOM   1221 C  CA  . PRO B 1 29  ? 30.61086 -43.44988 3.94405   1.000 19.07057 ? 27  PRO B CA  1 
ATOM   1222 C  C   . PRO B 1 29  ? 31.49012 -44.41143 3.16412   1.000 21.68833 ? 27  PRO B C   1 
ATOM   1223 O  O   . PRO B 1 29  ? 31.69048 -45.56959 3.53865   1.000 20.75817 ? 27  PRO B O   1 
ATOM   1224 C  CB  . PRO B 1 29  ? 31.37337 -42.88437 5.15127   1.000 22.52784 ? 27  PRO B CB  1 
ATOM   1225 C  CG  . PRO B 1 29  ? 31.03484 -43.83837 6.26828   1.000 24.86299 ? 27  PRO B CG  1 
ATOM   1226 C  CD  . PRO B 1 29  ? 29.60653 -44.24597 6.02117   1.000 21.89390 ? 27  PRO B CD  1 
ATOM   1227 N  N   . VAL B 1 30  ? 32.03929 -43.90364 2.06405   1.000 21.10727 ? 28  VAL B N   1 
ATOM   1228 C  CA  . VAL B 1 30  ? 33.02321 -44.62855 1.26887   1.000 20.58328 ? 28  VAL B CA  1 
ATOM   1229 C  C   . VAL B 1 30  ? 34.18485 -43.68945 0.98977   1.000 22.55860 ? 28  VAL B C   1 
ATOM   1230 O  O   . VAL B 1 30  ? 33.98145 -42.50005 0.72627   1.000 19.74133 ? 28  VAL B O   1 
ATOM   1231 C  CB  . VAL B 1 30  ? 32.42097 -45.17378 -0.04297  1.000 19.99391 ? 28  VAL B CB  1 
ATOM   1232 C  CG1 . VAL B 1 30  ? 33.47524 -45.96012 -0.81921  1.000 19.41588 ? 28  VAL B CG1 1 
ATOM   1233 C  CG2 . VAL B 1 30  ? 31.21479 -46.08681 0.26543   1.000 20.20873 ? 28  VAL B CG2 1 
ATOM   1234 N  N   . GLY B 1 31  ? 35.40466 -44.21180 1.07487   1.000 19.55376 ? 29  GLY B N   1 
ATOM   1235 C  CA  . GLY B 1 31  ? 36.59827 -43.40951 0.88619   1.000 18.74885 ? 29  GLY B CA  1 
ATOM   1236 C  C   . GLY B 1 31  ? 37.45882 -44.00000 -0.21037  1.000 19.23960 ? 29  GLY B C   1 
ATOM   1237 O  O   . GLY B 1 31  ? 37.46613 -45.21479 -0.42676  1.000 22.27967 ? 29  GLY B O   1 
ATOM   1238 N  N   . ALA B 1 32  ? 38.19492 -43.13143 -0.90162  1.000 17.34358 ? 30  ALA B N   1 
ATOM   1239 C  CA  . ALA B 1 32  ? 39.06777 -43.58068 -1.97466  1.000 18.48585 ? 30  ALA B CA  1 
ATOM   1240 C  C   . ALA B 1 32  ? 40.38449 -42.81797 -1.94832  1.000 21.22047 ? 30  ALA B C   1 
ATOM   1241 O  O   . ALA B 1 32  ? 40.43682 -41.64418 -1.56742  1.000 20.33592 ? 30  ALA B O   1 
ATOM   1242 C  CB  . ALA B 1 32  ? 38.40460 -43.41177 -3.35674  1.000 18.85200 ? 30  ALA B CB  1 
ATOM   1243 N  N   . CYS B 1 33  ? 41.44874 -43.50631 -2.37143  1.000 17.40218 ? 31  CYS B N   1 
ATOM   1244 C  CA  . CYS B 1 33  ? 42.75554 -42.90369 -2.62039  1.000 19.97771 ? 31  CYS B CA  1 
ATOM   1245 C  C   . CYS B 1 33  ? 43.20299 -43.32725 -4.00933  1.000 20.15920 ? 31  CYS B C   1 
ATOM   1246 O  O   . CYS B 1 33  ? 43.44324 -44.51458 -4.25292  1.000 22.47215 ? 31  CYS B O   1 
ATOM   1247 C  CB  . CYS B 1 33  ? 43.78539 -43.33232 -1.57309  1.000 19.90092 ? 31  CYS B CB  1 
ATOM   1248 S  SG  . CYS B 1 33  ? 45.41718 -42.64417 -1.91907  1.000 22.19816 ? 31  CYS B SG  1 
ATOM   1249 N  N   . LEU B 1 34  ? 43.30362 -42.36972 -4.92178  1.000 19.36062 ? 32  LEU B N   1 
ATOM   1250 C  CA  . LEU B 1 34  ? 43.76936 -42.61336 -6.27723  1.000 17.25370 ? 32  LEU B CA  1 
ATOM   1251 C  C   . LEU B 1 34  ? 45.19063 -42.07632 -6.42037  1.000 23.47584 ? 32  LEU B C   1 
ATOM   1252 O  O   . LEU B 1 34  ? 45.44371 -40.90331 -6.13445  1.000 20.66190 ? 32  LEU B O   1 
ATOM   1253 C  CB  . LEU B 1 34  ? 42.82773 -41.95400 -7.28855  1.000 18.36699 ? 32  LEU B CB  1 
ATOM   1254 C  CG  . LEU B 1 34  ? 43.21450 -42.02103 -8.76439  1.000 19.22628 ? 32  LEU B CG  1 
ATOM   1255 C  CD1 . LEU B 1 34  ? 43.24355 -43.45511 -9.27771  1.000 19.92302 ? 32  LEU B CD1 1 
ATOM   1256 C  CD2 . LEU B 1 34  ? 42.21849 -41.19249 -9.57180  1.000 20.29837 ? 32  LEU B CD2 1 
ATOM   1257 N  N   . VAL B 1 35  ? 46.11435 -42.93703 -6.85892  1.000 22.22089 ? 33  VAL B N   1 
ATOM   1258 C  CA  . VAL B 1 35  ? 47.53961 -42.61597 -6.90748  1.000 21.48759 ? 33  VAL B CA  1 
ATOM   1259 C  C   . VAL B 1 35  ? 47.98395 -42.46660 -8.35577  1.000 21.13619 ? 33  VAL B C   1 
ATOM   1260 O  O   . VAL B 1 35  ? 47.64814 -43.29647 -9.20501  1.000 21.15681 ? 33  VAL B O   1 
ATOM   1261 C  CB  . VAL B 1 35  ? 48.36643 -43.70181 -6.18711  1.000 21.00327 ? 33  VAL B CB  1 
ATOM   1262 C  CG1 . VAL B 1 35  ? 49.84195 -43.27163 -6.08080  1.000 25.16725 ? 33  VAL B CG1 1 
ATOM   1263 C  CG2 . VAL B 1 35  ? 47.77471 -43.99015 -4.82046  1.000 24.17883 ? 33  VAL B CG2 1 
ATOM   1264 N  N   . THR B 1 36  ? 48.76220 -41.42233 -8.63619  1.000 22.23073 ? 34  THR B N   1 
ATOM   1265 C  CA  . THR B 1 36  ? 49.31732 -41.20958 -9.96759  1.000 21.86574 ? 34  THR B CA  1 
ATOM   1266 C  C   . THR B 1 36  ? 50.73572 -41.78068 -10.05491 1.000 27.67346 ? 34  THR B C   1 
ATOM   1267 O  O   . THR B 1 36  ? 51.33791 -42.18460 -9.05741  1.000 28.23020 ? 34  THR B O   1 
ATOM   1268 C  CB  . THR B 1 36  ? 49.34879 -39.72000 -10.32457 1.000 28.13517 ? 34  THR B CB  1 
ATOM   1269 O  OG1 . THR B 1 36  ? 50.33367 -39.05822 -9.51705  1.000 27.21489 ? 34  THR B OG1 1 
ATOM   1270 C  CG2 . THR B 1 36  ? 47.98211 -39.07106 -10.10434 1.000 25.03515 ? 34  THR B CG2 1 
ATOM   1271 N  N   . GLU B 1 37  ? 51.27079 -41.78699 -11.27750 1.000 26.48491 ? 35  GLU B N   1 
ATOM   1272 C  CA  . GLU B 1 37  ? 52.62938 -42.28795 -11.49099 1.000 34.42596 ? 35  GLU B CA  1 
ATOM   1273 C  C   . GLU B 1 37  ? 53.65902 -41.44914 -10.73714 1.000 36.00892 ? 35  GLU B C   1 
ATOM   1274 O  O   . GLU B 1 37  ? 54.65805 -41.97921 -10.23298 1.000 36.54091 ? 35  GLU B O   1 
ATOM   1275 C  CB  . GLU B 1 37  ? 52.94686 -42.31139 -12.98560 1.000 33.25971 ? 35  GLU B CB  1 
ATOM   1276 C  CG  . GLU B 1 37  ? 54.40420 -42.61229 -13.29400 1.000 40.17901 ? 35  GLU B CG  1 
ATOM   1277 C  CD  . GLU B 1 37  ? 54.63159 -42.99769 -14.74412 1.000 50.03359 ? 35  GLU B CD  1 
ATOM   1278 O  OE1 . GLU B 1 37  ? 53.66872 -42.92653 -15.54416 1.000 46.77245 ? 35  GLU B OE1 1 
ATOM   1279 O  OE2 . GLU B 1 37  ? 55.77782 -43.37086 -15.08362 1.000 56.05336 ? 35  GLU B OE2 1 
ATOM   1280 N  N   . SER B 1 38  ? 53.42772 -40.14117 -10.63769 1.000 32.58961 ? 36  SER B N   1 
ATOM   1281 C  CA  . SER B 1 38  ? 54.32921 -39.26018 -9.90728  1.000 32.56223 ? 36  SER B CA  1 
ATOM   1282 C  C   . SER B 1 38  ? 54.22586 -39.42078 -8.39844  1.000 33.16901 ? 36  SER B C   1 
ATOM   1283 O  O   . SER B 1 38  ? 55.01038 -38.79434 -7.67568  1.000 32.53019 ? 36  SER B O   1 
ATOM   1284 C  CB  . SER B 1 38  ? 54.05489 -37.80802 -10.28715 1.000 37.20441 ? 36  SER B CB  1 
ATOM   1285 O  OG  . SER B 1 38  ? 52.82218 -37.37209 -9.73390  1.000 41.07633 ? 36  SER B OG  1 
ATOM   1286 N  N   . GLY B 1 39  ? 53.28603 -40.23251 -7.90532  1.000 27.56205 ? 37  GLY B N   1 
ATOM   1287 C  CA  . GLY B 1 39  ? 53.07600 -40.40251 -6.48938  1.000 28.99959 ? 37  GLY B CA  1 
ATOM   1288 C  C   . GLY B 1 39  ? 52.04831 -39.47103 -5.88911  1.000 27.00131 ? 37  GLY B C   1 
ATOM   1289 O  O   . GLY B 1 39  ? 51.71018 -39.63019 -4.70837  1.000 28.42301 ? 37  GLY B O   1 
ATOM   1290 N  N   . LYS B 1 40  ? 51.54597 -38.50590 -6.65875  1.000 26.51988 ? 38  LYS B N   1 
ATOM   1291 C  CA  . LYS B 1 40  ? 50.50333 -37.62308 -6.15603  1.000 28.27535 ? 38  LYS B CA  1 
ATOM   1292 C  C   . LYS B 1 40  ? 49.23888 -38.41626 -5.87521  1.000 25.23363 ? 38  LYS B C   1 
ATOM   1293 O  O   . LYS B 1 40  ? 48.85412 -39.29267 -6.65533  1.000 25.45229 ? 38  LYS B O   1 
ATOM   1294 C  CB  . LYS B 1 40  ? 50.20997 -36.50587 -7.15443  1.000 27.03496 ? 38  LYS B CB  1 
ATOM   1295 C  CG  . LYS B 1 40  ? 49.59288 -35.26708 -6.49703  1.000 31.19750 ? 38  LYS B CG  1 
ATOM   1296 C  CD  . LYS B 1 40  ? 49.42865 -34.11430 -7.47969  1.000 35.73239 ? 38  LYS B CD  1 
ATOM   1297 C  CE  . LYS B 1 40  ? 49.04717 -32.82646 -6.74938  1.000 42.60925 ? 38  LYS B CE  1 
ATOM   1298 N  NZ  . LYS B 1 40  ? 47.81134 -32.18185 -7.31810  1.000 41.31928 ? 38  LYS B NZ  1 
ATOM   1299 N  N   . ILE B 1 41  ? 48.59152 -38.10753 -4.75246  1.000 23.72804 ? 39  ILE B N   1 
ATOM   1300 C  CA  . ILE B 1 41  ? 47.41620 -38.85362 -4.32418  1.000 22.95817 ? 39  ILE B CA  1 
ATOM   1301 C  C   . ILE B 1 41  ? 46.19578 -37.94204 -4.37629  1.000 23.97366 ? 39  ILE B C   1 
ATOM   1302 O  O   . ILE B 1 41  ? 46.26433 -36.73510 -4.09656  1.000 20.09205 ? 39  ILE B O   1 
ATOM   1303 C  CB  . ILE B 1 41  ? 47.58527 -39.47999 -2.92153  1.000 26.72387 ? 39  ILE B CB  1 
ATOM   1304 C  CG1 . ILE B 1 41  ? 47.42864 -38.45739 -1.81781  1.000 33.10574 ? 39  ILE B CG1 1 
ATOM   1305 C  CG2 . ILE B 1 41  ? 48.94391 -40.16250 -2.77870  1.000 29.00943 ? 39  ILE B CG2 1 
ATOM   1306 C  CD1 . ILE B 1 41  ? 46.03722 -38.47344 -1.21137  1.000 35.43368 ? 39  ILE B CD1 1 
ATOM   1307 N  N   . TYR B 1 42  ? 45.05959 -38.54283 -4.73171  1.000 21.22983 ? 40  TYR B N   1 
ATOM   1308 C  CA  . TYR B 1 42  ? 43.77922 -37.84505 -4.80869  1.000 22.21244 ? 40  TYR B CA  1 
ATOM   1309 C  C   . TYR B 1 42  ? 42.76759 -38.59383 -3.95187  1.000 19.50596 ? 40  TYR B C   1 
ATOM   1310 O  O   . TYR B 1 42  ? 42.54147 -39.79248 -4.15783  1.000 20.87694 ? 40  TYR B O   1 
ATOM   1311 C  CB  . TYR B 1 42  ? 43.30676 -37.73941 -6.26021  1.000 20.16888 ? 40  TYR B CB  1 
ATOM   1312 C  CG  . TYR B 1 42  ? 44.15466 -36.77433 -7.05767  1.000 19.34346 ? 40  TYR B CG  1 
ATOM   1313 C  CD1 . TYR B 1 42  ? 45.35119 -37.17552 -7.65013  1.000 21.03441 ? 40  TYR B CD1 1 
ATOM   1314 C  CD2 . TYR B 1 42  ? 43.79186 -35.44296 -7.15710  1.000 19.06196 ? 40  TYR B CD2 1 
ATOM   1315 C  CE1 . TYR B 1 42  ? 46.13188 -36.27339 -8.35529  1.000 22.41913 ? 40  TYR B CE1 1 
ATOM   1316 C  CE2 . TYR B 1 42  ? 44.56736 -34.53777 -7.85728  1.000 21.44157 ? 40  TYR B CE2 1 
ATOM   1317 C  CZ  . TYR B 1 42  ? 45.73556 -34.95729 -8.44771  1.000 23.14541 ? 40  TYR B CZ  1 
ATOM   1318 O  OH  . TYR B 1 42  ? 46.49110 -34.04304 -9.14838  1.000 23.80313 ? 40  TYR B OH  1 
ATOM   1319 N  N   . GLN B 1 43  ? 42.18833 -37.89670 -2.97659  1.000 19.50687 ? 41  GLN B N   1 
ATOM   1320 C  CA  . GLN B 1 43  ? 41.21622 -38.47785 -2.06144  1.000 19.96946 ? 41  GLN B CA  1 
ATOM   1321 C  C   . GLN B 1 43  ? 39.79959 -38.30758 -2.60189  1.000 19.70645 ? 41  GLN B C   1 
ATOM   1322 O  O   . GLN B 1 43  ? 39.44290 -37.23555 -3.09184  1.000 20.18513 ? 41  GLN B O   1 
ATOM   1323 C  CB  . GLN B 1 43  ? 41.32558 -37.80677 -0.69598  1.000 19.95417 ? 41  GLN B CB  1 
ATOM   1324 C  CG  . GLN B 1 43  ? 40.46594 -38.43175 0.38307   1.000 18.08527 ? 41  GLN B CG  1 
ATOM   1325 C  CD  . GLN B 1 43  ? 40.64240 -37.71049 1.70068   1.000 26.08814 ? 41  GLN B CD  1 
ATOM   1326 O  OE1 . GLN B 1 43  ? 40.40687 -36.50260 1.79454   1.000 20.89869 ? 41  GLN B OE1 1 
ATOM   1327 N  NE2 . GLN B 1 43  ? 41.14874 -38.43022 2.71038   1.000 23.69056 ? 41  GLN B NE2 1 
ATOM   1328 N  N   . GLY B 1 44  ? 38.99579 -39.36422 -2.50334  1.000 18.89686 ? 42  GLY B N   1 
ATOM   1329 C  CA  . GLY B 1 44  ? 37.60382 -39.31857 -2.91710  1.000 16.35000 ? 42  GLY B CA  1 
ATOM   1330 C  C   . GLY B 1 44  ? 36.67881 -39.62283 -1.75220  1.000 18.84312 ? 42  GLY B C   1 
ATOM   1331 O  O   . GLY B 1 44  ? 37.03609 -40.36857 -0.83989  1.000 18.43942 ? 42  GLY B O   1 
ATOM   1332 N  N   . ILE B 1 45  ? 35.48243 -39.01075 -1.77990  1.000 15.96334 ? 43  ILE B N   1 
ATOM   1333 C  CA  . ILE B 1 45  ? 34.39331 -39.30058 -0.84696  1.000 15.29434 ? 43  ILE B CA  1 
ATOM   1334 C  C   . ILE B 1 45  ? 33.13508 -39.49763 -1.67486  1.000 16.12100 ? 43  ILE B C   1 
ATOM   1335 O  O   . ILE B 1 45  ? 33.02294 -38.94783 -2.77521  1.000 16.34517 ? 43  ILE B O   1 
ATOM   1336 C  CB  . ILE B 1 45  ? 34.14824 -38.16247 0.17964   1.000 19.63191 ? 43  ILE B CB  1 
ATOM   1337 C  CG1 . ILE B 1 45  ? 33.89953 -36.82259 -0.55348  1.000 18.46144 ? 43  ILE B CG1 1 
ATOM   1338 C  CG2 . ILE B 1 45  ? 35.29182 -38.07409 1.22796   1.000 18.52037 ? 43  ILE B CG2 1 
ATOM   1339 C  CD1 . ILE B 1 45  ? 33.13882 -35.76867 0.29670   1.000 19.42598 ? 43  ILE B CD1 1 
ATOM   1340 N  N   . ASN B 1 46  ? 32.17437 -40.26705 -1.14712  1.000 17.75378 ? 44  ASN B N   1 
ATOM   1341 C  CA  . ASN B 1 46  ? 30.86319 -40.26971 -1.79387  1.000 19.12506 ? 44  ASN B CA  1 
ATOM   1342 C  C   . ASN B 1 46  ? 30.09102 -39.01165 -1.39669  1.000 16.71863 ? 44  ASN B C   1 
ATOM   1343 O  O   . ASN B 1 46  ? 30.28382 -38.44234 -0.31516  1.000 16.32371 ? 44  ASN B O   1 
ATOM   1344 C  CB  . ASN B 1 46  ? 30.05165 -41.55336 -1.50419  1.000 15.94388 ? 44  ASN B CB  1 
ATOM   1345 C  CG  . ASN B 1 46  ? 29.99807 -41.95136 -0.02047  1.000 21.51721 ? 44  ASN B CG  1 
ATOM   1346 O  OD1 . ASN B 1 46  ? 30.85698 -41.58591 0.78616   1.000 19.07497 ? 44  ASN B OD1 1 
ATOM   1347 N  ND2 . ASN B 1 46  ? 28.98726 -42.75487 0.32126   1.000 17.95815 ? 44  ASN B ND2 1 
ATOM   1348 N  N   . ILE B 1 47  ? 29.29063 -38.50991 -2.33642  1.000 14.48461 ? 45  ILE B N   1 
ATOM   1349 C  CA  . ILE B 1 47  ? 28.58749 -37.23834 -2.18862  1.000 15.86544 ? 45  ILE B CA  1 
ATOM   1350 C  C   . ILE B 1 47  ? 27.14450 -37.46625 -2.62904  1.000 15.65014 ? 45  ILE B C   1 
ATOM   1351 O  O   . ILE B 1 47  ? 26.86807 -37.61241 -3.82494  1.000 14.95936 ? 45  ILE B O   1 
ATOM   1352 C  CB  . ILE B 1 47  ? 29.27556 -36.13524 -3.02051  1.000 13.94674 ? 45  ILE B CB  1 
ATOM   1353 C  CG1 . ILE B 1 47  ? 30.73791 -35.98732 -2.57700  1.000 18.40586 ? 45  ILE B CG1 1 
ATOM   1354 C  CG2 . ILE B 1 47  ? 28.50501 -34.80121 -2.92031  1.000 15.04217 ? 45  ILE B CG2 1 
ATOM   1355 C  CD1 . ILE B 1 47  ? 31.54828 -35.05904 -3.43293  1.000 17.15971 ? 45  ILE B CD1 1 
ATOM   1356 N  N   . GLU B 1 48  ? 26.22221 -37.54444 -1.67682  1.000 14.65648 ? 46  GLU B N   1 
ATOM   1357 C  CA  . GLU B 1 48  ? 24.85276 -37.91273 -2.01911  1.000 14.93452 ? 46  GLU B CA  1 
ATOM   1358 C  C   . GLU B 1 48  ? 24.04767 -36.67849 -2.42717  1.000 16.46209 ? 46  GLU B C   1 
ATOM   1359 O  O   . GLU B 1 48  ? 24.49393 -35.53920 -2.29731  1.000 13.98159 ? 46  GLU B O   1 
ATOM   1360 C  CB  . GLU B 1 48  ? 24.19505 -38.65588 -0.85062  1.000 16.91288 ? 46  GLU B CB  1 
ATOM   1361 C  CG  . GLU B 1 48  ? 25.01035 -39.90668 -0.48714  1.000 14.45841 ? 46  GLU B CG  1 
ATOM   1362 C  CD  . GLU B 1 48  ? 24.38979 -40.78615 0.58743   1.000 17.50521 ? 46  GLU B CD  1 
ATOM   1363 O  OE1 . GLU B 1 48  ? 23.64920 -40.26869 1.44148   1.000 17.79360 ? 46  GLU B OE1 1 
ATOM   1364 O  OE2 . GLU B 1 48  ? 24.70121 -42.00238 0.58731   1.000 17.63879 ? 46  GLU B OE2 1 
ATOM   1365 N  N   . ASN B 1 49  ? 22.84819 -36.93537 -2.96009  1.000 14.92257 ? 47  ASN B N   1 
ATOM   1366 C  CA  . ASN B 1 49  ? 21.90048 -35.90699 -3.37486  1.000 16.01078 ? 47  ASN B CA  1 
ATOM   1367 C  C   . ASN B 1 49  ? 20.51386 -36.33679 -2.92843  1.000 15.61525 ? 47  ASN B C   1 
ATOM   1368 O  O   . ASN B 1 49  ? 20.20328 -37.53140 -2.92250  1.000 16.13279 ? 47  ASN B O   1 
ATOM   1369 C  CB  . ASN B 1 49  ? 21.91083 -35.71725 -4.91104  1.000 14.94832 ? 47  ASN B CB  1 
ATOM   1370 C  CG  . ASN B 1 49  ? 21.16261 -34.47250 -5.35534  1.000 17.73945 ? 47  ASN B CG  1 
ATOM   1371 O  OD1 . ASN B 1 49  ? 19.94540 -34.50169 -5.57700  1.000 16.30652 ? 47  ASN B OD1 1 
ATOM   1372 N  ND2 . ASN B 1 49  ? 21.88417 -33.36819 -5.47690  1.000 13.94004 ? 47  ASN B ND2 1 
ATOM   1373 N  N   . ALA B 1 50  ? 19.67813 -35.35398 -2.56890  1.000 15.66695 ? 48  ALA B N   1 
ATOM   1374 C  CA  . ALA B 1 50  ? 18.30106 -35.65330 -2.17883  1.000 16.05861 ? 48  ALA B CA  1 
ATOM   1375 C  C   . ALA B 1 50  ? 17.59100 -36.48125 -3.23894  1.000 14.73800 ? 48  ALA B C   1 
ATOM   1376 O  O   . ALA B 1 50  ? 16.72917 -37.29953 -2.91531  1.000 15.52757 ? 48  ALA B O   1 
ATOM   1377 C  CB  . ALA B 1 50  ? 17.53098 -34.35499 -1.92319  1.000 18.49461 ? 48  ALA B CB  1 
ATOM   1378 N  N   . SER B 1 51  ? 17.89503 -36.24267 -4.51312  1.000 14.28678 ? 49  SER B N   1 
ATOM   1379 C  CA  . SER B 1 51  ? 17.50117 -37.14903 -5.58673  1.000 15.75158 ? 49  SER B CA  1 
ATOM   1380 C  C   . SER B 1 51  ? 18.61324 -38.18821 -5.69443  1.000 16.14526 ? 49  SER B C   1 
ATOM   1381 O  O   . SER B 1 51  ? 19.71542 -37.88277 -6.16747  1.000 15.40609 ? 49  SER B O   1 
ATOM   1382 C  CB  . SER B 1 51  ? 17.30346 -36.37953 -6.89171  1.000 14.62951 ? 49  SER B CB  1 
ATOM   1383 O  OG  . SER B 1 51  ? 16.85793 -37.26683 -7.91331  1.000 15.75170 ? 49  SER B OG  1 
ATOM   1384 N  N   . PHE B 1 52  ? 18.33680 -39.41540 -5.22434  1.000 14.91135 ? 50  PHE B N   1 
ATOM   1385 C  CA  . PHE B 1 52  ? 19.41063 -40.38058 -4.98050  1.000 14.47036 ? 50  PHE B CA  1 
ATOM   1386 C  C   . PHE B 1 52  ? 20.24714 -40.62765 -6.22191  1.000 17.94163 ? 50  PHE B C   1 
ATOM   1387 O  O   . PHE B 1 52  ? 21.45564 -40.84601 -6.11897  1.000 14.08940 ? 50  PHE B O   1 
ATOM   1388 C  CB  . PHE B 1 52  ? 18.83691 -41.70853 -4.47650  1.000 14.67359 ? 50  PHE B CB  1 
ATOM   1389 C  CG  . PHE B 1 52  ? 18.54802 -41.73903 -2.98483  1.000 17.15342 ? 50  PHE B CG  1 
ATOM   1390 C  CD1 . PHE B 1 52  ? 18.49471 -40.57370 -2.22954  1.000 18.52016 ? 50  PHE B CD1 1 
ATOM   1391 C  CD2 . PHE B 1 52  ? 18.32643 -42.96075 -2.35033  1.000 18.51297 ? 50  PHE B CD2 1 
ATOM   1392 C  CE1 . PHE B 1 52  ? 18.21689 -40.62042 -0.85444  1.000 19.65703 ? 50  PHE B CE1 1 
ATOM   1393 C  CE2 . PHE B 1 52  ? 18.06225 -43.02358 -0.97564  1.000 18.87011 ? 50  PHE B CE2 1 
ATOM   1394 C  CZ  . PHE B 1 52  ? 18.00244 -41.85883 -0.23226  1.000 19.82190 ? 50  PHE B CZ  1 
ATOM   1395 N  N   . GLY B 1 53  ? 19.61705 -40.63074 -7.40405  1.000 14.81941 ? 51  GLY B N   1 
ATOM   1396 C  CA  . GLY B 1 53  ? 20.32279 -40.93483 -8.63793  1.000 14.93742 ? 51  GLY B CA  1 
ATOM   1397 C  C   . GLY B 1 53  ? 21.36009 -39.90973 -9.05603  1.000 16.63614 ? 51  GLY B C   1 
ATOM   1398 O  O   . GLY B 1 53  ? 22.06965 -40.14551 -10.03701 1.000 19.07084 ? 51  GLY B O   1 
ATOM   1399 N  N   . LEU B 1 54  ? 21.46721 -38.78874 -8.35847  1.000 13.48548 ? 52  LEU B N   1 
ATOM   1400 C  CA  . LEU B 1 54  ? 22.54131 -37.84993 -8.62596  1.000 15.09890 ? 52  LEU B CA  1 
ATOM   1401 C  C   . LEU B 1 54  ? 23.70086 -38.02001 -7.64615  1.000 15.14511 ? 52  LEU B C   1 
ATOM   1402 O  O   . LEU B 1 54  ? 24.65243 -37.23787 -7.69113  1.000 14.54077 ? 52  LEU B O   1 
ATOM   1403 C  CB  . LEU B 1 54  ? 22.00258 -36.42160 -8.58500  1.000 15.14976 ? 52  LEU B CB  1 
ATOM   1404 C  CG  . LEU B 1 54  ? 21.01463 -36.16586 -9.72748  1.000 18.78812 ? 52  LEU B CG  1 
ATOM   1405 C  CD1 . LEU B 1 54  ? 20.48206 -34.76592 -9.62130  1.000 19.78000 ? 52  LEU B CD1 1 
ATOM   1406 C  CD2 . LEU B 1 54  ? 21.71769 -36.35937 -11.07497 1.000 20.73742 ? 52  LEU B CD2 1 
ATOM   1407 N  N   . THR B 1 55  ? 23.63155 -39.02073 -6.76304  1.000 15.26385 ? 53  THR B N   1 
ATOM   1408 C  CA  . THR B 1 55  ? 24.76262 -39.35424 -5.88973  1.000 13.44040 ? 53  THR B CA  1 
ATOM   1409 C  C   . THR B 1 55  ? 26.00885 -39.70803 -6.69989  1.000 15.22860 ? 53  THR B C   1 
ATOM   1410 O  O   . THR B 1 55  ? 25.92869 -40.38501 -7.73705  1.000 15.50789 ? 53  THR B O   1 
ATOM   1411 C  CB  . THR B 1 55  ? 24.36802 -40.53818 -4.99481  1.000 14.64855 ? 53  THR B CB  1 
ATOM   1412 O  OG1 . THR B 1 55  ? 23.31307 -40.12776 -4.13429  1.000 15.76403 ? 53  THR B OG1 1 
ATOM   1413 C  CG2 . THR B 1 55  ? 25.54325 -41.04269 -4.15266  1.000 14.67312 ? 53  THR B CG2 1 
ATOM   1414 N  N   . ASN B 1 56  ? 27.17883 -39.28220 -6.20885  1.000 15.12544 ? 54  ASN B N   1 
ATOM   1415 C  CA  . ASN B 1 56  ? 28.45810 -39.65449 -6.80656  1.000 12.93947 ? 54  ASN B CA  1 
ATOM   1416 C  C   . ASN B 1 56  ? 29.27826 -40.48280 -5.82146  1.000 17.08580 ? 54  ASN B C   1 
ATOM   1417 O  O   . ASN B 1 56  ? 29.36459 -40.14524 -4.63433  1.000 16.99908 ? 54  ASN B O   1 
ATOM   1418 C  CB  . ASN B 1 56  ? 29.25600 -38.42596 -7.24698  1.000 14.07429 ? 54  ASN B CB  1 
ATOM   1419 C  CG  . ASN B 1 56  ? 30.30716 -38.77503 -8.27334  1.000 17.20983 ? 54  ASN B CG  1 
ATOM   1420 O  OD1 . ASN B 1 56  ? 29.98564 -39.34070 -9.33706  1.000 17.52178 ? 54  ASN B OD1 1 
ATOM   1421 N  ND2 . ASN B 1 56  ? 31.56437 -38.44304 -7.98548  1.000 17.32653 ? 54  ASN B ND2 1 
ATOM   1422 N  N   . CYS B 1 57  ? 29.85974 -41.57032 -6.31584  1.000 16.05953 ? 55  CYS B N   1 
ATOM   1423 C  CA  . CYS B 1 57  ? 30.65945 -42.48133 -5.50663  1.000 15.15422 ? 55  CYS B CA  1 
ATOM   1424 C  C   . CYS B 1 57  ? 32.02558 -41.89925 -5.17842  1.000 16.74672 ? 55  CYS B C   1 
ATOM   1425 O  O   . CYS B 1 57  ? 32.58084 -41.08455 -5.91989  1.000 17.92580 ? 55  CYS B O   1 
ATOM   1426 C  CB  . CYS B 1 57  ? 30.87910 -43.80252 -6.23861  1.000 17.06530 ? 55  CYS B CB  1 
ATOM   1427 S  SG  . CYS B 1 57  ? 29.35853 -44.73504 -6.50682  1.000 17.46538 ? 55  CYS B SG  1 
ATOM   1428 N  N   . ALA B 1 58  ? 32.61387 -42.41448 -4.09347  1.000 16.70565 ? 56  ALA B N   1 
ATOM   1429 C  CA  . ALA B 1 58  ? 33.95808 -41.97647 -3.71230  1.000 15.95492 ? 56  ALA B CA  1 
ATOM   1430 C  C   . ALA B 1 58  ? 34.97693 -42.24693 -4.81091  1.000 16.30782 ? 56  ALA B C   1 
ATOM   1431 O  O   . ALA B 1 58  ? 35.83412 -41.39952 -5.09468  1.000 16.98615 ? 56  ALA B O   1 
ATOM   1432 C  CB  . ALA B 1 58  ? 34.37952 -42.66810 -2.42023  1.000 16.28941 ? 56  ALA B CB  1 
ATOM   1433 N  N   . GLU B 1 59  ? 34.92698 -43.43608 -5.41745  1.000 15.71703 ? 57  GLU B N   1 
ATOM   1434 C  CA  . GLU B 1 59  ? 35.88189 -43.76345 -6.47014  1.000 17.62961 ? 57  GLU B CA  1 
ATOM   1435 C  C   . GLU B 1 59  ? 35.79671 -42.75800 -7.60884  1.000 16.32017 ? 57  GLU B C   1 
ATOM   1436 O  O   . GLU B 1 59  ? 36.81827 -42.24844 -8.07784  1.000 16.63606 ? 57  GLU B O   1 
ATOM   1437 C  CB  . GLU B 1 59  ? 35.64114 -45.19204 -6.97036  1.000 18.92195 ? 57  GLU B CB  1 
ATOM   1438 C  CG  . GLU B 1 59  ? 35.69455 -46.22942 -5.84833  1.000 19.08565 ? 57  GLU B CG  1 
ATOM   1439 C  CD  . GLU B 1 59  ? 34.33475 -46.55024 -5.24208  1.000 20.56403 ? 57  GLU B CD  1 
ATOM   1440 O  OE1 . GLU B 1 59  ? 33.60763 -45.61733 -4.82765  1.000 17.16428 ? 57  GLU B OE1 1 
ATOM   1441 O  OE2 . GLU B 1 59  ? 33.99176 -47.74966 -5.16327  1.000 21.14818 ? 57  GLU B OE2 1 
ATOM   1442 N  N   . ARG B 1 60  ? 34.57896 -42.43300 -8.05754  1.000 16.33049 ? 58  ARG B N   1 
ATOM   1443 C  CA  . ARG B 1 60  ? 34.45288 -41.47279 -9.14936  1.000 15.21766 ? 58  ARG B CA  1 
ATOM   1444 C  C   . ARG B 1 60  ? 34.84500 -40.05867 -8.72782  1.000 14.78650 ? 58  ARG B C   1 
ATOM   1445 O  O   . ARG B 1 60  ? 35.42655 -39.32173 -9.52797  1.000 16.93491 ? 58  ARG B O   1 
ATOM   1446 C  CB  . ARG B 1 60  ? 33.03036 -41.51780 -9.71135  1.000 15.75707 ? 58  ARG B CB  1 
ATOM   1447 C  CG  . ARG B 1 60  ? 32.85119 -42.75989 -10.59918 1.000 15.79720 ? 58  ARG B CG  1 
ATOM   1448 C  CD  . ARG B 1 60  ? 31.43535 -42.88128 -11.16384 1.000 15.20113 ? 58  ARG B CD  1 
ATOM   1449 N  NE  . ARG B 1 60  ? 30.45733 -43.29164 -10.15879 1.000 17.42997 ? 58  ARG B NE  1 
ATOM   1450 C  CZ  . ARG B 1 60  ? 29.14950 -43.11381 -10.29103 1.000 19.62588 ? 58  ARG B CZ  1 
ATOM   1451 N  NH1 . ARG B 1 60  ? 28.63941 -42.48593 -11.34574 1.000 16.50163 ? 58  ARG B NH1 1 
ATOM   1452 N  NH2 . ARG B 1 60  ? 28.32773 -43.59665 -9.35770  1.000 17.85070 ? 58  ARG B NH2 1 
ATOM   1453 N  N   . THR B 1 61  ? 34.58405 -39.67739 -7.47449  1.000 16.36797 ? 59  THR B N   1 
ATOM   1454 C  CA  . THR B 1 61  ? 35.03061 -38.36697 -7.00861  1.000 16.20006 ? 59  THR B CA  1 
ATOM   1455 C  C   . THR B 1 61  ? 36.54395 -38.24831 -7.12346  1.000 18.15521 ? 59  THR B C   1 
ATOM   1456 O  O   . THR B 1 61  ? 37.06122 -37.22536 -7.58700  1.000 16.73025 ? 59  THR B O   1 
ATOM   1457 C  CB  . THR B 1 61  ? 34.58141 -38.13350 -5.56887  1.000 16.61892 ? 59  THR B CB  1 
ATOM   1458 O  OG1 . THR B 1 61  ? 33.14667 -38.03115 -5.52932  1.000 15.56261 ? 59  THR B OG1 1 
ATOM   1459 C  CG2 . THR B 1 61  ? 35.20573 -36.84958 -4.98712  1.000 16.46362 ? 59  THR B CG2 1 
ATOM   1460 N  N   . ALA B 1 62  ? 37.26250 -39.30390 -6.73710  1.000 16.97987 ? 60  ALA B N   1 
ATOM   1461 C  CA  . ALA B 1 62  ? 38.72074 -39.28018 -6.83356  1.000 16.31478 ? 60  ALA B CA  1 
ATOM   1462 C  C   . ALA B 1 62  ? 39.16117 -39.12505 -8.28441  1.000 15.99930 ? 60  ALA B C   1 
ATOM   1463 O  O   . ALA B 1 62  ? 40.01844 -38.29151 -8.59828  1.000 16.87562 ? 60  ALA B O   1 
ATOM   1464 C  CB  . ALA B 1 62  ? 39.29864 -40.55038 -6.20842  1.000 17.92823 ? 60  ALA B CB  1 
ATOM   1465 N  N   . PHE B 1 63  ? 38.55643 -39.89874 -9.19647  1.000 16.46203 ? 61  PHE B N   1 
ATOM   1466 C  CA  . PHE B 1 63  ? 38.91347 -39.77184 -10.60953 1.000 16.38076 ? 61  PHE B CA  1 
ATOM   1467 C  C   . PHE B 1 63  ? 38.57925 -38.39187 -11.14983 1.000 17.50576 ? 61  PHE B C   1 
ATOM   1468 O  O   . PHE B 1 63  ? 39.37484 -37.80707 -11.89007 1.000 17.36558 ? 61  PHE B O   1 
ATOM   1469 C  CB  . PHE B 1 63  ? 38.21971 -40.85671 -11.43151 1.000 16.62590 ? 61  PHE B CB  1 
ATOM   1470 C  CG  . PHE B 1 63  ? 38.96880 -42.14806 -11.44546 1.000 16.64413 ? 61  PHE B CG  1 
ATOM   1471 C  CD1 . PHE B 1 63  ? 40.04834 -42.32161 -12.30023 1.000 17.45537 ? 61  PHE B CD1 1 
ATOM   1472 C  CD2 . PHE B 1 63  ? 38.63918 -43.16605 -10.56027 1.000 17.30285 ? 61  PHE B CD2 1 
ATOM   1473 C  CE1 . PHE B 1 63  ? 40.77679 -43.50964 -12.29192 1.000 19.99383 ? 61  PHE B CE1 1 
ATOM   1474 C  CE2 . PHE B 1 63  ? 39.36335 -44.36143 -10.54558 1.000 20.23462 ? 61  PHE B CE2 1 
ATOM   1475 C  CZ  . PHE B 1 63  ? 40.43378 -44.52820 -11.41965 1.000 17.45660 ? 61  PHE B CZ  1 
ATOM   1476 N  N   . PHE B 1 64  ? 37.40809 -37.84976 -10.80470 1.000 16.47609 ? 62  PHE B N   1 
ATOM   1477 C  CA  . PHE B 1 64  ? 37.05534 -36.54031 -11.35056 1.000 15.27561 ? 62  PHE B CA  1 
ATOM   1478 C  C   . PHE B 1 64  ? 38.01915 -35.47120 -10.84951 1.000 16.19484 ? 62  PHE B C   1 
ATOM   1479 O  O   . PHE B 1 64  ? 38.41319 -34.58022 -11.61057 1.000 18.04740 ? 62  PHE B O   1 
ATOM   1480 C  CB  . PHE B 1 64  ? 35.61009 -36.18352 -11.01053 1.000 13.99780 ? 62  PHE B CB  1 
ATOM   1481 C  CG  . PHE B 1 64  ? 34.59448 -37.13819 -11.60329 1.000 15.60498 ? 62  PHE B CG  1 
ATOM   1482 C  CD1 . PHE B 1 64  ? 34.93305 -37.93708 -12.69107 1.000 14.45747 ? 62  PHE B CD1 1 
ATOM   1483 C  CD2 . PHE B 1 64  ? 33.31189 -37.24832 -11.06465 1.000 17.01158 ? 62  PHE B CD2 1 
ATOM   1484 C  CE1 . PHE B 1 64  ? 34.01196 -38.83347 -13.23520 1.000 16.65328 ? 62  PHE B CE1 1 
ATOM   1485 C  CE2 . PHE B 1 64  ? 32.38991 -38.14073 -11.60311 1.000 16.15904 ? 62  PHE B CE2 1 
ATOM   1486 C  CZ  . PHE B 1 64  ? 32.74272 -38.92577 -12.69596 1.000 15.43300 ? 62  PHE B CZ  1 
ATOM   1487 N  N   . LYS B 1 65  ? 38.43598 -35.56176 -9.58286  1.000 14.82742 ? 63  LYS B N   1 
ATOM   1488 C  CA  . LYS B 1 65  ? 39.43649 -34.62189 -9.08101  1.000 15.83693 ? 63  LYS B CA  1 
ATOM   1489 C  C   . LYS B 1 65  ? 40.73547 -34.74549 -9.86898  1.000 16.78740 ? 63  LYS B C   1 
ATOM   1490 O  O   . LYS B 1 65  ? 41.23432 -33.75871 -10.41761 1.000 17.02279 ? 63  LYS B O   1 
ATOM   1491 C  CB  . LYS B 1 65  ? 39.67681 -34.83930 -7.58400  1.000 18.12855 ? 63  LYS B CB  1 
ATOM   1492 C  CG  . LYS B 1 65  ? 38.47743 -34.42680 -6.70558  1.000 17.16346 ? 63  LYS B CG  1 
ATOM   1493 C  CD  . LYS B 1 65  ? 38.65930 -34.87366 -5.24938  1.000 22.48431 ? 63  LYS B CD  1 
ATOM   1494 C  CE  . LYS B 1 65  ? 39.83248 -34.17400 -4.57438  1.000 20.07492 ? 63  LYS B CE  1 
ATOM   1495 N  NZ  . LYS B 1 65  ? 39.77887 -34.43177 -3.11432  1.000 18.84539 ? 63  LYS B NZ  1 
ATOM   1496 N  N   . ALA B 1 66  ? 41.28577 -35.96105 -9.95595  1.000 17.01886 ? 64  ALA B N   1 
ATOM   1497 C  CA  . ALA B 1 66  ? 42.56505 -36.15233 -10.63410 1.000 16.93952 ? 64  ALA B CA  1 
ATOM   1498 C  C   . ALA B 1 66  ? 42.48917 -35.73048 -12.09508 1.000 18.41884 ? 64  ALA B C   1 
ATOM   1499 O  O   . ALA B 1 66  ? 43.36266 -35.01410 -12.59596 1.000 17.15763 ? 64  ALA B O   1 
ATOM   1500 C  CB  . ALA B 1 66  ? 43.00215 -37.61321 -10.52277 1.000 18.00631 ? 64  ALA B CB  1 
ATOM   1501 N  N   . VAL B 1 67  ? 41.45316 -36.17491 -12.80234 1.000 18.04521 ? 65  VAL B N   1 
ATOM   1502 C  CA  . VAL B 1 67  ? 41.37261 -35.86926 -14.22820 1.000 18.14777 ? 65  VAL B CA  1 
ATOM   1503 C  C   . VAL B 1 67  ? 41.22741 -34.36757 -14.45377 1.000 17.78763 ? 65  VAL B C   1 
ATOM   1504 O  O   . VAL B 1 67  ? 41.76221 -33.82418 -15.42773 1.000 18.85789 ? 65  VAL B O   1 
ATOM   1505 C  CB  . VAL B 1 67  ? 40.22553 -36.67626 -14.87754 1.000 16.74840 ? 65  VAL B CB  1 
ATOM   1506 C  CG1 . VAL B 1 67  ? 39.91637 -36.16660 -16.28429 1.000 19.23943 ? 65  VAL B CG1 1 
ATOM   1507 C  CG2 . VAL B 1 67  ? 40.56963 -38.18019 -14.90344 1.000 15.52178 ? 65  VAL B CG2 1 
ATOM   1508 N  N   . SER B 1 68  ? 40.53491 -33.66371 -13.55203 1.000 16.40993 ? 66  SER B N   1 
ATOM   1509 C  CA  . SER B 1 68  ? 40.40004 -32.21678 -13.69389 1.000 17.23862 ? 66  SER B CA  1 
ATOM   1510 C  C   . SER B 1 68  ? 41.72454 -31.49573 -13.51095 1.000 20.87977 ? 66  SER B C   1 
ATOM   1511 O  O   . SER B 1 68  ? 41.87398 -30.36622 -13.99121 1.000 20.83530 ? 66  SER B O   1 
ATOM   1512 C  CB  . SER B 1 68  ? 39.40169 -31.64183 -12.68568 1.000 16.25636 ? 66  SER B CB  1 
ATOM   1513 O  OG  . SER B 1 68  ? 40.00200 -31.46904 -11.40560 1.000 18.59171 ? 66  SER B OG  1 
ATOM   1514 N  N   . GLU B 1 69  ? 42.67001 -32.09523 -12.79682 1.000 19.20829 ? 67  GLU B N   1 
ATOM   1515 C  CA  . GLU B 1 69  ? 43.98823 -31.48903 -12.65523 1.000 18.96174 ? 67  GLU B CA  1 
ATOM   1516 C  C   . GLU B 1 69  ? 44.94414 -31.94297 -13.74839 1.000 22.70252 ? 67  GLU B C   1 
ATOM   1517 O  O   . GLU B 1 69  ? 46.14340 -31.65799 -13.66199 1.000 23.80035 ? 67  GLU B O   1 
ATOM   1518 C  CB  . GLU B 1 69  ? 44.57470 -31.80385 -11.27905 1.000 20.71987 ? 67  GLU B CB  1 
ATOM   1519 C  CG  . GLU B 1 69  ? 43.60963 -31.58581 -10.11612 1.000 24.83594 ? 67  GLU B CG  1 
ATOM   1520 C  CD  . GLU B 1 69  ? 43.24764 -30.12716 -9.88174  1.000 28.33356 ? 67  GLU B CD  1 
ATOM   1521 O  OE1 . GLU B 1 69  ? 43.91431 -29.22322 -10.44412 1.000 27.35937 ? 67  GLU B OE1 1 
ATOM   1522 O  OE2 . GLU B 1 69  ? 42.27900 -29.88026 -9.11898  1.000 28.49641 ? 67  GLU B OE2 1 
ATOM   1523 N  N   . GLY B 1 70  ? 44.44297 -32.64881 -14.76308 1.000 21.62531 ? 68  GLY B N   1 
ATOM   1524 C  CA  . GLY B 1 70  ? 45.25193 -33.07401 -15.88796 1.000 21.56500 ? 68  GLY B CA  1 
ATOM   1525 C  C   . GLY B 1 70  ? 45.93318 -34.41386 -15.73132 1.000 25.56782 ? 68  GLY B C   1 
ATOM   1526 O  O   . GLY B 1 70  ? 46.73360 -34.78434 -16.60063 1.000 23.81561 ? 68  GLY B O   1 
ATOM   1527 N  N   . GLU B 1 71  ? 45.64390 -35.15464 -14.66189 1.000 21.21736 ? 69  GLU B N   1 
ATOM   1528 C  CA  . GLU B 1 71  ? 46.29194 -36.43929 -14.44481 1.000 21.01822 ? 69  GLU B CA  1 
ATOM   1529 C  C   . GLU B 1 71  ? 45.74602 -37.46016 -15.43133 1.000 25.20934 ? 69  GLU B C   1 
ATOM   1530 O  O   . GLU B 1 71  ? 44.53132 -37.55554 -15.63319 1.000 21.32677 ? 69  GLU B O   1 
ATOM   1531 C  CB  . GLU B 1 71  ? 46.06780 -36.93449 -13.01487 1.000 22.78057 ? 69  GLU B CB  1 
ATOM   1532 C  CG  . GLU B 1 71  ? 46.43091 -35.97131 -11.88157 1.000 24.29773 ? 69  GLU B CG  1 
ATOM   1533 C  CD  . GLU B 1 71  ? 47.94057 -35.76132 -11.70341 1.000 30.23370 ? 69  GLU B CD  1 
ATOM   1534 O  OE1 . GLU B 1 71  ? 48.74896 -36.37380 -12.44614 1.000 26.05085 ? 69  GLU B OE1 1 
ATOM   1535 O  OE2 . GLU B 1 71  ? 48.30524 -35.02266 -10.76342 1.000 26.61569 ? 69  GLU B OE2 1 
ATOM   1536 N  N   . ARG B 1 72  ? 46.63721 -38.22825 -16.05338 1.000 20.76128 ? 70  ARG B N   1 
ATOM   1537 C  CA  . ARG B 1 72  ? 46.19562 -39.30116 -16.93341 1.000 22.57829 ? 70  ARG B CA  1 
ATOM   1538 C  C   . ARG B 1 72  ? 46.93100 -40.61648 -16.71556 1.000 26.04936 ? 70  ARG B C   1 
ATOM   1539 O  O   . ARG B 1 72  ? 46.64280 -41.58937 -17.42652 1.000 28.10587 ? 70  ARG B O   1 
ATOM   1540 C  CB  . ARG B 1 72  ? 46.33689 -38.88578 -18.40398 1.000 23.18849 ? 70  ARG B CB  1 
ATOM   1541 C  CG  . ARG B 1 72  ? 45.54039 -37.65971 -18.81734 1.000 29.12086 ? 70  ARG B CG  1 
ATOM   1542 C  CD  . ARG B 1 72  ? 44.02238 -37.90512 -18.82362 1.000 23.01846 ? 70  ARG B CD  1 
ATOM   1543 N  NE  . ARG B 1 72  ? 43.33313 -36.73437 -19.35164 1.000 23.35500 ? 70  ARG B NE  1 
ATOM   1544 C  CZ  . ARG B 1 72  ? 42.98502 -35.67411 -18.62897 1.000 21.72455 ? 70  ARG B CZ  1 
ATOM   1545 N  NH1 . ARG B 1 72  ? 43.22838 -35.61407 -17.32757 1.000 21.44930 ? 70  ARG B NH1 1 
ATOM   1546 N  NH2 . ARG B 1 72  ? 42.35983 -34.65806 -19.22484 1.000 22.18225 ? 70  ARG B NH2 1 
ATOM   1547 N  N   . SER B 1 73  ? 47.84944 -40.69267 -15.75917 1.000 22.83797 ? 71  SER B N   1 
ATOM   1548 C  CA  . SER B 1 73  ? 48.62351 -41.91661 -15.53170 1.000 22.81037 ? 71  SER B CA  1 
ATOM   1549 C  C   . SER B 1 73  ? 48.42350 -42.36471 -14.09282 1.000 25.27164 ? 71  SER B C   1 
ATOM   1550 O  O   . SER B 1 73  ? 49.01492 -41.79584 -13.17051 1.000 25.49669 ? 71  SER B O   1 
ATOM   1551 C  CB  . SER B 1 73  ? 50.10303 -41.69891 -15.83568 1.000 29.48379 ? 71  SER B CB  1 
ATOM   1552 O  OG  . SER B 1 73  ? 50.27041 -41.26280 -17.16718 1.000 36.86800 ? 71  SER B OG  1 
ATOM   1553 N  N   . PHE B 1 74  ? 47.61769 -43.40261 -13.89309 1.000 21.13922 ? 72  PHE B N   1 
ATOM   1554 C  CA  . PHE B 1 74  ? 47.28687 -43.86761 -12.55756 1.000 22.76761 ? 72  PHE B CA  1 
ATOM   1555 C  C   . PHE B 1 74  ? 47.94149 -45.21105 -12.27982 1.000 23.08174 ? 72  PHE B C   1 
ATOM   1556 O  O   . PHE B 1 74  ? 48.04425 -46.05436 -13.17159 1.000 25.72170 ? 72  PHE B O   1 
ATOM   1557 C  CB  . PHE B 1 74  ? 45.76502 -43.93678 -12.40038 1.000 21.68984 ? 72  PHE B CB  1 
ATOM   1558 C  CG  . PHE B 1 74  ? 45.11693 -42.62198 -12.68857 1.000 19.52835 ? 72  PHE B CG  1 
ATOM   1559 C  CD1 . PHE B 1 74  ? 45.27939 -41.56702 -11.80550 1.000 20.29123 ? 72  PHE B CD1 1 
ATOM   1560 C  CD2 . PHE B 1 74  ? 44.43696 -42.40645 -13.88288 1.000 22.76174 ? 72  PHE B CD2 1 
ATOM   1561 C  CE1 . PHE B 1 74  ? 44.73078 -40.32111 -12.07493 1.000 21.90835 ? 72  PHE B CE1 1 
ATOM   1562 C  CE2 . PHE B 1 74  ? 43.86957 -41.16644 -14.16301 1.000 21.42119 ? 72  PHE B CE2 1 
ATOM   1563 C  CZ  . PHE B 1 74  ? 44.02025 -40.11268 -13.24878 1.000 19.40891 ? 72  PHE B CZ  1 
ATOM   1564 N  N   . THR B 1 75  ? 48.38059 -45.40004 -11.03590 1.000 20.80700 ? 73  THR B N   1 
ATOM   1565 C  CA  . THR B 1 75  ? 49.11605 -46.59724 -10.65660 1.000 26.60031 ? 73  THR B CA  1 
ATOM   1566 C  C   . THR B 1 75  ? 48.45181 -47.41513 -9.56240  1.000 26.59170 ? 73  THR B C   1 
ATOM   1567 O  O   . THR B 1 75  ? 48.84252 -48.57217 -9.36304  1.000 27.25101 ? 73  THR B O   1 
ATOM   1568 C  CB  . THR B 1 75  ? 50.53644 -46.23774 -10.18581 1.000 27.38333 ? 73  THR B CB  1 
ATOM   1569 O  OG1 . THR B 1 75  ? 50.46932 -45.23892 -9.15812  1.000 28.36338 ? 73  THR B OG1 1 
ATOM   1570 C  CG2 . THR B 1 75  ? 51.34910 -45.70808 -11.35141 1.000 31.98913 ? 73  THR B CG2 1 
ATOM   1571 N  N   . HIS B 1 76  ? 47.46653 -46.87136 -8.85434  1.000 23.30602 ? 74  HIS B N   1 
ATOM   1572 C  CA  . HIS B 1 76  ? 46.84977 -47.62998 -7.77376  1.000 21.72017 ? 74  HIS B CA  1 
ATOM   1573 C  C   . HIS B 1 76  ? 45.57092 -46.92840 -7.34992  1.000 23.89692 ? 74  HIS B C   1 
ATOM   1574 O  O   . HIS B 1 76  ? 45.49038 -45.69859 -7.38481  1.000 21.54432 ? 74  HIS B O   1 
ATOM   1575 C  CB  . HIS B 1 76  ? 47.79063 -47.75764 -6.56626  1.000 22.44059 ? 74  HIS B CB  1 
ATOM   1576 C  CG  . HIS B 1 76  ? 47.54735 -48.98130 -5.74067  1.000 26.67710 ? 74  HIS B CG  1 
ATOM   1577 N  ND1 . HIS B 1 76  ? 48.36279 -50.09294 -5.80295  1.000 29.68843 ? 74  HIS B ND1 1 
ATOM   1578 C  CD2 . HIS B 1 76  ? 46.58172 -49.27325 -4.83871  1.000 24.91332 ? 74  HIS B CD2 1 
ATOM   1579 C  CE1 . HIS B 1 76  ? 47.91172 -51.01375 -4.97026  1.000 27.80947 ? 74  HIS B CE1 1 
ATOM   1580 N  NE2 . HIS B 1 76  ? 46.82892 -50.54308 -4.37582  1.000 30.12191 ? 74  HIS B NE2 1 
ATOM   1581 N  N   . LEU B 1 77  ? 44.58789 -47.72110 -6.92863  1.000 21.49728 ? 75  LEU B N   1 
ATOM   1582 C  CA  . LEU B 1 77  ? 43.36549 -47.20234 -6.32352  1.000 20.26913 ? 75  LEU B CA  1 
ATOM   1583 C  C   . LEU B 1 77  ? 43.09171 -47.99239 -5.05338  1.000 22.94218 ? 75  LEU B C   1 
ATOM   1584 O  O   . LEU B 1 77  ? 42.99593 -49.22454 -5.09799  1.000 24.08056 ? 75  LEU B O   1 
ATOM   1585 C  CB  . LEU B 1 77  ? 42.17371 -47.31795 -7.28540  1.000 21.51533 ? 75  LEU B CB  1 
ATOM   1586 C  CG  . LEU B 1 77  ? 40.82023 -46.92778 -6.67487  1.000 19.59522 ? 75  LEU B CG  1 
ATOM   1587 C  CD1 . LEU B 1 77  ? 40.76542 -45.42252 -6.45695  1.000 20.74487 ? 75  LEU B CD1 1 
ATOM   1588 C  CD2 . LEU B 1 77  ? 39.66634 -47.38671 -7.56067  1.000 18.93773 ? 75  LEU B CD2 1 
ATOM   1589 N  N   . VAL B 1 78  ? 42.96426 -47.29751 -3.92760  1.000 20.18894 ? 76  VAL B N   1 
ATOM   1590 C  CA  . VAL B 1 78  ? 42.50234 -47.89159 -2.67602  1.000 19.79301 ? 76  VAL B CA  1 
ATOM   1591 C  C   . VAL B 1 78  ? 41.08426 -47.40141 -2.41632  1.000 21.76765 ? 76  VAL B C   1 
ATOM   1592 O  O   . VAL B 1 78  ? 40.80628 -46.20492 -2.54641  1.000 20.69347 ? 76  VAL B O   1 
ATOM   1593 C  CB  . VAL B 1 78  ? 43.42771 -47.53804 -1.49898  1.000 25.67097 ? 76  VAL B CB  1 
ATOM   1594 C  CG1 . VAL B 1 78  ? 42.97687 -48.27095 -0.22673  1.000 22.76671 ? 76  VAL B CG1 1 
ATOM   1595 C  CG2 . VAL B 1 78  ? 44.88876 -47.85082 -1.85347  1.000 23.25734 ? 76  VAL B CG2 1 
ATOM   1596 N  N   . VAL B 1 79  ? 40.19259 -48.31936 -2.04442  1.000 23.16278 ? 77  VAL B N   1 
ATOM   1597 C  CA  . VAL B 1 79  ? 38.81817 -47.99198 -1.68538  1.000 22.88992 ? 77  VAL B CA  1 
ATOM   1598 C  C   . VAL B 1 79  ? 38.53798 -48.59180 -0.31177  1.000 23.29806 ? 77  VAL B C   1 
ATOM   1599 O  O   . VAL B 1 79  ? 38.85072 -49.76355 -0.06843  1.000 23.89580 ? 77  VAL B O   1 
ATOM   1600 C  CB  . VAL B 1 79  ? 37.82320 -48.52872 -2.73524  1.000 18.65810 ? 77  VAL B CB  1 
ATOM   1601 C  CG1 . VAL B 1 79  ? 36.45084 -47.88282 -2.58709  1.000 24.19062 ? 77  VAL B CG1 1 
ATOM   1602 C  CG2 . VAL B 1 79  ? 38.35928 -48.34121 -4.13505  1.000 19.78152 ? 77  VAL B CG2 1 
ATOM   1603 N  N   . ALA B 1 80  ? 37.95479 -47.79826 0.58351   1.000 21.75403 ? 78  ALA B N   1 
ATOM   1604 C  CA  . ALA B 1 80  ? 37.66770 -48.24407 1.94262   1.000 24.44216 ? 78  ALA B CA  1 
ATOM   1605 C  C   . ALA B 1 80  ? 36.20798 -48.00698 2.30885   1.000 25.94146 ? 78  ALA B C   1 
ATOM   1606 O  O   . ALA B 1 80  ? 35.60220 -47.01065 1.89990   1.000 23.05098 ? 78  ALA B O   1 
ATOM   1607 C  CB  . ALA B 1 80  ? 38.56681 -47.52016 2.96577   1.000 24.36274 ? 78  ALA B CB  1 
ATOM   1608 N  N   . GLY B 1 81  ? 35.65688 -48.92507 3.11774   1.000 22.23343 ? 79  GLY B N   1 
ATOM   1609 C  CA  . GLY B 1 81  ? 34.35330 -48.72858 3.71789   1.000 26.51224 ? 79  GLY B CA  1 
ATOM   1610 C  C   . GLY B 1 81  ? 34.32429 -49.23994 5.14651   1.000 27.53677 ? 79  GLY B C   1 
ATOM   1611 O  O   . GLY B 1 81  ? 35.24040 -49.93349 5.58698   1.000 28.76967 ? 79  GLY B O   1 
ATOM   1612 N  N   . HIS B 1 82  ? 33.26711 -48.86127 5.87779   1.000 27.53143 ? 80  HIS B N   1 
ATOM   1613 C  CA  . HIS B 1 82  ? 32.99466 -49.43402 7.20619   1.000 31.82579 ? 80  HIS B CA  1 
ATOM   1614 C  C   . HIS B 1 82  ? 32.17620 -50.71227 7.03303   1.000 28.46417 ? 80  HIS B C   1 
ATOM   1615 O  O   . HIS B 1 82  ? 30.99803 -50.79847 7.39229   1.000 31.15105 ? 80  HIS B O   1 
ATOM   1616 C  CB  . HIS B 1 82  ? 32.26847 -48.44288 8.11088   1.000 31.30259 ? 80  HIS B CB  1 
ATOM   1617 C  CG  . HIS B 1 82  ? 33.14079 -47.36024 8.66437   1.000 32.69480 ? 80  HIS B CG  1 
ATOM   1618 N  ND1 . HIS B 1 82  ? 34.37139 -47.61098 9.23264   1.000 34.14058 ? 80  HIS B ND1 1 
ATOM   1619 C  CD2 . HIS B 1 82  ? 32.94339 -46.02376 8.76732   1.000 30.90340 ? 80  HIS B CD2 1 
ATOM   1620 C  CE1 . HIS B 1 82  ? 34.90599 -46.47241 9.63967   1.000 33.91923 ? 80  HIS B CE1 1 
ATOM   1621 N  NE2 . HIS B 1 82  ? 34.05909 -45.49414 9.37010   1.000 33.61508 ? 80  HIS B NE2 1 
ATOM   1622 N  N   . THR B 1 83  ? 32.83171 -51.71473 6.46015   1.000 25.26795 ? 81  THR B N   1 
ATOM   1623 C  CA  . THR B 1 83  ? 32.19161 -52.95060 6.04196   1.000 30.02033 ? 81  THR B CA  1 
ATOM   1624 C  C   . THR B 1 83  ? 32.93925 -54.16290 6.58612   1.000 31.86366 ? 81  THR B C   1 
ATOM   1625 O  O   . THR B 1 83  ? 34.16850 -54.13345 6.71189   1.000 28.23925 ? 81  THR B O   1 
ATOM   1626 C  CB  . THR B 1 83  ? 32.14426 -53.02127 4.50946   1.000 31.11129 ? 81  THR B CB  1 
ATOM   1627 O  OG1 . THR B 1 83  ? 33.45109 -52.73898 3.98645   1.000 30.10312 ? 81  THR B OG1 1 
ATOM   1628 C  CG2 . THR B 1 83  ? 31.15307 -51.99089 3.96132   1.000 26.96796 ? 81  THR B CG2 1 
ATOM   1629 N  N   . PRO B 1 84  ? 32.22291 -55.25214 6.89804   1.000 32.43438 ? 82  PRO B N   1 
ATOM   1630 C  CA  . PRO B 1 84  ? 32.89932 -56.43379 7.47766   1.000 30.55235 ? 82  PRO B CA  1 
ATOM   1631 C  C   . PRO B 1 84  ? 33.88155 -57.10161 6.53547   1.000 35.33673 ? 82  PRO B C   1 
ATOM   1632 O  O   . PRO B 1 84  ? 34.91454 -57.61813 6.98393   1.000 34.87439 ? 82  PRO B O   1 
ATOM   1633 C  CB  . PRO B 1 84  ? 31.73964 -57.37975 7.82728   1.000 34.21848 ? 82  PRO B CB  1 
ATOM   1634 C  CG  . PRO B 1 84  ? 30.48799 -56.60911 7.65699   1.000 36.89013 ? 82  PRO B CG  1 
ATOM   1635 C  CD  . PRO B 1 84  ? 30.76354 -55.42083 6.80548   1.000 34.59788 ? 82  PRO B CD  1 
ATOM   1636 N  N   . ASP B 1 85  ? 33.57054 -57.14852 5.24962   1.000 28.86228 ? 83  ASP B N   1 
ATOM   1637 C  CA  . ASP B 1 85  ? 34.49273 -57.57104 4.21519   1.000 29.77442 ? 83  ASP B CA  1 
ATOM   1638 C  C   . ASP B 1 85  ? 34.95186 -56.35342 3.42419   1.000 31.21859 ? 83  ASP B C   1 
ATOM   1639 O  O   . ASP B 1 85  ? 34.32663 -55.28847 3.50872   1.000 30.63560 ? 83  ASP B O   1 
ATOM   1640 C  CB  . ASP B 1 85  ? 33.84093 -58.60294 3.28303   1.000 30.35125 ? 83  ASP B CB  1 
ATOM   1641 C  CG  . ASP B 1 85  ? 33.19297 -59.75709 4.04214   1.000 40.68715 ? 83  ASP B CG  1 
ATOM   1642 O  OD1 . ASP B 1 85  ? 33.50682 -59.94133 5.23412   1.000 45.31736 ? 83  ASP B OD1 1 
ATOM   1643 O  OD2 . ASP B 1 85  ? 32.38604 -60.49559 3.44416   1.000 44.00943 ? 83  ASP B OD2 1 
ATOM   1644 N  N   . PRO B 1 86  ? 36.06426 -56.45251 2.68337   1.000 29.72103 ? 84  PRO B N   1 
ATOM   1645 C  CA  . PRO B 1 86  ? 36.52801 -55.29986 1.89918   1.000 27.16872 ? 84  PRO B CA  1 
ATOM   1646 C  C   . PRO B 1 86  ? 35.41778 -54.76485 1.00329   1.000 27.49535 ? 84  PRO B C   1 
ATOM   1647 O  O   . PRO B 1 86  ? 34.69841 -55.52403 0.34599   1.000 25.15609 ? 84  PRO B O   1 
ATOM   1648 C  CB  . PRO B 1 86  ? 37.69041 -55.87154 1.08112   1.000 26.83569 ? 84  PRO B CB  1 
ATOM   1649 C  CG  . PRO B 1 86  ? 38.22479 -56.99192 1.95699   1.000 31.61658 ? 84  PRO B CG  1 
ATOM   1650 C  CD  . PRO B 1 86  ? 37.00168 -57.59261 2.58766   1.000 32.12943 ? 84  PRO B CD  1 
ATOM   1651 N  N   . ILE B 1 87  ? 35.28048 -53.43859 0.98415   1.000 24.36211 ? 85  ILE B N   1 
ATOM   1652 C  CA  . ILE B 1 87  ? 34.19635 -52.83531 0.22344   1.000 23.54292 ? 85  ILE B CA  1 
ATOM   1653 C  C   . ILE B 1 87  ? 34.38715 -53.09486 -1.26959  1.000 24.76770 ? 85  ILE B C   1 
ATOM   1654 O  O   . ILE B 1 87  ? 35.51256 -53.18421 -1.78521  1.000 21.52095 ? 85  ILE B O   1 
ATOM   1655 C  CB  . ILE B 1 87  ? 34.10083 -51.33324 0.54713   1.000 23.48737 ? 85  ILE B CB  1 
ATOM   1656 C  CG1 . ILE B 1 87  ? 32.77493 -50.76524 0.00052   1.000 23.24519 ? 85  ILE B CG1 1 
ATOM   1657 C  CG2 . ILE B 1 87  ? 35.34866 -50.61039 0.03108   1.000 21.98557 ? 85  ILE B CG2 1 
ATOM   1658 C  CD1 . ILE B 1 87  ? 32.36913 -49.47890 0.61253   1.000 27.56683 ? 85  ILE B CD1 1 
ATOM   1659 N  N   . SER B 1 88  ? 33.25983 -53.23263 -1.97968  1.000 20.06643 ? 86  SER B N   1 
ATOM   1660 C  CA  . SER B 1 88  ? 33.24080 -53.52477 -3.39475  1.000 21.66204 ? 86  SER B CA  1 
ATOM   1661 C  C   . SER B 1 88  ? 32.89678 -52.27243 -4.17066  1.000 20.99569 ? 86  SER B C   1 
ATOM   1662 O  O   . SER B 1 88  ? 31.88165 -51.63030 -3.84650  1.000 21.48084 ? 86  SER B O   1 
ATOM   1663 C  CB  . SER B 1 88  ? 32.19635 -54.59182 -3.69222  1.000 22.07674 ? 86  SER B CB  1 
ATOM   1664 O  OG  . SER B 1 88  ? 32.04786 -54.74604 -5.08728  1.000 22.64909 ? 86  SER B OG  1 
ATOM   1665 N  N   . PRO B 1 89  ? 33.68680 -51.89534 -5.17683  1.000 18.16127 ? 87  PRO B N   1 
ATOM   1666 C  CA  . PRO B 1 89  ? 33.27720 -50.78511 -6.04696  1.000 18.56949 ? 87  PRO B CA  1 
ATOM   1667 C  C   . PRO B 1 89  ? 32.07276 -51.18482 -6.88269  1.000 21.50743 ? 87  PRO B C   1 
ATOM   1668 O  O   . PRO B 1 89  ? 31.99785 -52.30309 -7.39821  1.000 18.82442 ? 87  PRO B O   1 
ATOM   1669 C  CB  . PRO B 1 89  ? 34.51186 -50.54119 -6.92725  1.000 19.57018 ? 87  PRO B CB  1 
ATOM   1670 C  CG  . PRO B 1 89  ? 35.66460 -51.18686 -6.15314  1.000 21.40771 ? 87  PRO B CG  1 
ATOM   1671 C  CD  . PRO B 1 89  ? 35.03953 -52.37873 -5.51006  1.000 20.13429 ? 87  PRO B CD  1 
ATOM   1672 N  N   . CYS B 1 90  ? 31.12769 -50.25691 -7.02410  1.000 16.96754 ? 88  CYS B N   1 
ATOM   1673 C  CA  . CYS B 1 90  ? 29.97629 -50.54301 -7.86720  1.000 16.03252 ? 88  CYS B CA  1 
ATOM   1674 C  C   . CYS B 1 90  ? 30.37034 -50.54662 -9.34366  1.000 18.04978 ? 88  CYS B C   1 
ATOM   1675 O  O   . CYS B 1 90  ? 31.44981 -50.09241 -9.73881  1.000 15.57782 ? 88  CYS B O   1 
ATOM   1676 C  CB  . CYS B 1 90  ? 28.85737 -49.53654 -7.59134  1.000 15.32986 ? 88  CYS B CB  1 
ATOM   1677 S  SG  . CYS B 1 90  ? 28.95424 -48.00418 -8.55885  1.000 16.57229 ? 88  CYS B SG  1 
ATOM   1678 N  N   . GLY B 1 91  ? 29.45910 -51.06349 -10.17584 1.000 15.91964 ? 89  GLY B N   1 
ATOM   1679 C  CA  . GLY B 1 91  ? 29.75574 -51.21745 -11.59290 1.000 15.06899 ? 89  GLY B CA  1 
ATOM   1680 C  C   . GLY B 1 91  ? 30.00418 -49.90575 -12.30796 1.000 17.59496 ? 89  GLY B C   1 
ATOM   1681 O  O   . GLY B 1 91  ? 30.81805 -49.84480 -13.22887 1.000 16.87592 ? 89  GLY B O   1 
ATOM   1682 N  N   . ALA B 1 92  ? 29.29606 -48.83989 -11.91399 1.000 16.38247 ? 90  ALA B N   1 
ATOM   1683 C  CA  . ALA B 1 92  ? 29.54267 -47.54712 -12.54416 1.000 16.52449 ? 90  ALA B CA  1 
ATOM   1684 C  C   . ALA B 1 92  ? 30.97489 -47.09634 -12.30343 1.000 13.69577 ? 90  ALA B C   1 
ATOM   1685 O  O   . ALA B 1 92  ? 31.63333 -46.59637 -13.21978 1.000 15.33654 ? 90  ALA B O   1 
ATOM   1686 C  CB  . ALA B 1 92  ? 28.56572 -46.49231 -12.02448 1.000 15.50227 ? 90  ALA B CB  1 
ATOM   1687 N  N   . CYS B 1 93  ? 31.46149 -47.25272 -11.06565 1.000 14.63628 ? 91  CYS B N   1 
ATOM   1688 C  CA  . CYS B 1 93  ? 32.83763 -46.89174 -10.75001 1.000 16.95217 ? 91  CYS B CA  1 
ATOM   1689 C  C   . CYS B 1 93  ? 33.82200 -47.73727 -11.53742 1.000 16.07622 ? 91  CYS B C   1 
ATOM   1690 O  O   . CYS B 1 93  ? 34.83221 -47.22796 -12.03383 1.000 15.88384 ? 91  CYS B O   1 
ATOM   1691 C  CB  . CYS B 1 93  ? 33.07760 -47.04585 -9.25244  1.000 17.46533 ? 91  CYS B CB  1 
ATOM   1692 S  SG  . CYS B 1 93  ? 32.27497 -45.72037 -8.32386  1.000 17.03483 ? 91  CYS B SG  1 
ATOM   1693 N  N   . ARG B 1 94  ? 33.54591 -49.03480 -11.66454 1.000 15.19960 ? 92  ARG B N   1 
ATOM   1694 C  CA  . ARG B 1 94  ? 34.44328 -49.89230 -12.43227 1.000 17.75592 ? 92  ARG B CA  1 
ATOM   1695 C  C   . ARG B 1 94  ? 34.55349 -49.43750 -13.88289 1.000 17.04082 ? 92  ARG B C   1 
ATOM   1696 O  O   . ARG B 1 94  ? 35.62858 -49.53989 -14.48154 1.000 19.23287 ? 92  ARG B O   1 
ATOM   1697 C  CB  . ARG B 1 94  ? 33.96983 -51.34426 -12.32821 1.000 17.57629 ? 92  ARG B CB  1 
ATOM   1698 C  CG  . ARG B 1 94  ? 34.04307 -51.90508 -10.89793 1.000 18.74633 ? 92  ARG B CG  1 
ATOM   1699 C  CD  . ARG B 1 94  ? 33.41315 -53.30083 -10.79554 1.000 18.51902 ? 92  ARG B CD  1 
ATOM   1700 N  NE  . ARG B 1 94  ? 33.28030 -53.72708 -9.40478  1.000 20.51463 ? 92  ARG B NE  1 
ATOM   1701 C  CZ  . ARG B 1 94  ? 33.11949 -54.98714 -9.01644  1.000 19.66660 ? 92  ARG B CZ  1 
ATOM   1702 N  NH1 . ARG B 1 94  ? 33.11596 -55.98203 -9.88750  1.000 19.92758 ? 92  ARG B NH1 1 
ATOM   1703 N  NH2 . ARG B 1 94  ? 32.93743 -55.25029 -7.72867  1.000 21.13483 ? 92  ARG B NH2 1 
ATOM   1704 N  N   . GLN B 1 95  ? 33.46943 -48.89827 -14.45427 1.000 15.79393 ? 93  GLN B N   1 
ATOM   1705 C  CA  . GLN B 1 95  ? 33.49774 -48.41352 -15.82977 1.000 15.12082 ? 93  GLN B CA  1 
ATOM   1706 C  C   . GLN B 1 95  ? 34.30590 -47.12212 -15.96188 1.000 16.90647 ? 93  GLN B C   1 
ATOM   1707 O  O   . GLN B 1 95  ? 34.99117 -46.90973 -16.97633 1.000 17.53879 ? 93  GLN B O   1 
ATOM   1708 C  CB  . GLN B 1 95  ? 32.06737 -48.20537 -16.32683 1.000 16.38675 ? 93  GLN B CB  1 
ATOM   1709 C  CG  . GLN B 1 95  ? 31.93794 -47.89657 -17.81643 1.000 16.87323 ? 93  GLN B CG  1 
ATOM   1710 C  CD  . GLN B 1 95  ? 32.28919 -49.07341 -18.70096 1.000 18.87757 ? 93  GLN B CD  1 
ATOM   1711 O  OE1 . GLN B 1 95  ? 31.78821 -50.18477 -18.49695 1.000 18.58597 ? 93  GLN B OE1 1 
ATOM   1712 N  NE2 . GLN B 1 95  ? 33.12840 -48.83321 -19.71612 1.000 19.58875 ? 93  GLN B NE2 1 
ATOM   1713 N  N   . VAL B 1 96  ? 34.21615 -46.22972 -14.96726 1.000 15.17516 ? 94  VAL B N   1 
ATOM   1714 C  CA  . VAL B 1 96  ? 35.07868 -45.05090 -14.96644 1.000 14.16928 ? 94  VAL B CA  1 
ATOM   1715 C  C   . VAL B 1 96  ? 36.54258 -45.46018 -14.78099 1.000 15.59743 ? 94  VAL B C   1 
ATOM   1716 O  O   . VAL B 1 96  ? 37.43196 -44.93481 -15.45953 1.000 17.61254 ? 94  VAL B O   1 
ATOM   1717 C  CB  . VAL B 1 96  ? 34.62305 -44.04083 -13.89699 1.000 14.54404 ? 94  VAL B CB  1 
ATOM   1718 C  CG1 . VAL B 1 96  ? 35.63045 -42.87632 -13.78537 1.000 16.47081 ? 94  VAL B CG1 1 
ATOM   1719 C  CG2 . VAL B 1 96  ? 33.23928 -43.47722 -14.27293 1.000 15.18248 ? 94  VAL B CG2 1 
ATOM   1720 N  N   . MET B 1 97  ? 36.81804 -46.40661 -13.87812 1.000 16.92501 ? 95  MET B N   1 
ATOM   1721 C  CA  . MET B 1 97  ? 38.19468 -46.90591 -13.77436 1.000 17.28796 ? 95  MET B CA  1 
ATOM   1722 C  C   . MET B 1 97  ? 38.71172 -47.45045 -15.10243 1.000 19.82434 ? 95  MET B C   1 
ATOM   1723 O  O   . MET B 1 97  ? 39.86735 -47.21046 -15.46976 1.000 21.65567 ? 95  MET B O   1 
ATOM   1724 C  CB  . MET B 1 97  ? 38.34217 -47.97523 -12.68306 1.000 18.19813 ? 95  MET B CB  1 
ATOM   1725 C  CG  . MET B 1 97  ? 37.94263 -47.50666 -11.28181 1.000 18.77504 ? 95  MET B CG  1 
ATOM   1726 S  SD  . MET B 1 97  ? 37.24197 -48.73542 -10.18489 1.000 23.86912 ? 95  MET B SD  1 
ATOM   1727 C  CE  . MET B 1 97  ? 38.50728 -49.99199 -10.24835 1.000 20.35506 ? 95  MET B CE  1 
ATOM   1728 N  N   . ALA B 1 98  ? 37.87008 -48.16751 -15.84935 1.000 19.17835 ? 96  ALA B N   1 
ATOM   1729 C  CA  . ALA B 1 98  ? 38.31658 -48.70489 -17.13063 1.000 19.28629 ? 96  ALA B CA  1 
ATOM   1730 C  C   . ALA B 1 98  ? 38.58486 -47.60457 -18.14910 1.000 22.05221 ? 96  ALA B C   1 
ATOM   1731 O  O   . ALA B 1 98  ? 39.44337 -47.77396 -19.02144 1.000 19.66446 ? 96  ALA B O   1 
ATOM   1732 C  CB  . ALA B 1 98  ? 37.27842 -49.69480 -17.65999 1.000 21.45663 ? 96  ALA B CB  1 
ATOM   1733 N  N   . GLU B 1 99  ? 37.88273 -46.46648 -18.04439 1.000 18.56441 ? 97  GLU B N   1 
ATOM   1734 C  CA  . GLU B 1 99  ? 38.13233 -45.34530 -18.94459 1.000 16.86748 ? 97  GLU B CA  1 
ATOM   1735 C  C   . GLU B 1 99  ? 39.55540 -44.82292 -18.79484 1.000 20.18119 ? 97  GLU B C   1 
ATOM   1736 O  O   . GLU B 1 99  ? 40.19322 -44.44835 -19.78288 1.000 20.63411 ? 97  GLU B O   1 
ATOM   1737 C  CB  . GLU B 1 99  ? 37.13143 -44.21165 -18.67011 1.000 17.07768 ? 97  GLU B CB  1 
ATOM   1738 C  CG  . GLU B 1 99  ? 37.20018 -43.01368 -19.65703 1.000 17.31327 ? 97  GLU B CG  1 
ATOM   1739 C  CD  . GLU B 1 99  ? 36.49128 -43.29517 -20.98915 1.000 18.40487 ? 97  GLU B CD  1 
ATOM   1740 O  OE1 . GLU B 1 99  ? 35.67832 -44.25347 -21.06063 1.000 18.17806 ? 97  GLU B OE1 1 
ATOM   1741 O  OE2 . GLU B 1 99  ? 36.72223 -42.54530 -21.97115 1.000 19.48607 ? 97  GLU B OE2 1 
ATOM   1742 N  N   . PHE B 1 100 ? 40.07866 -44.79813 -17.56702 1.000 18.12786 ? 98  PHE B N   1 
ATOM   1743 C  CA  . PHE B 1 100 ? 41.30670 -44.06439 -17.30579 1.000 18.72097 ? 98  PHE B CA  1 
ATOM   1744 C  C   . PHE B 1 100 ? 42.48301 -44.91644 -16.87632 1.000 21.50134 ? 98  PHE B C   1 
ATOM   1745 O  O   . PHE B 1 100 ? 43.59779 -44.38356 -16.79435 1.000 22.19415 ? 98  PHE B O   1 
ATOM   1746 C  CB  . PHE B 1 100 ? 41.05952 -42.98471 -16.24184 1.000 16.66900 ? 98  PHE B CB  1 
ATOM   1747 C  CG  . PHE B 1 100 ? 40.11729 -41.91196 -16.70892 1.000 16.83506 ? 98  PHE B CG  1 
ATOM   1748 C  CD1 . PHE B 1 100 ? 40.51083 -41.01567 -17.70606 1.000 16.01701 ? 98  PHE B CD1 1 
ATOM   1749 C  CD2 . PHE B 1 100 ? 38.83033 -41.81762 -16.18296 1.000 19.08693 ? 98  PHE B CD2 1 
ATOM   1750 C  CE1 . PHE B 1 100 ? 39.63351 -40.03559 -18.16713 1.000 19.95490 ? 98  PHE B CE1 1 
ATOM   1751 C  CE2 . PHE B 1 100 ? 37.96031 -40.83454 -16.62335 1.000 19.44690 ? 98  PHE B CE2 1 
ATOM   1752 C  CZ  . PHE B 1 100 ? 38.35388 -39.94482 -17.61979 1.000 19.41123 ? 98  PHE B CZ  1 
ATOM   1753 N  N   . CYS B 1 101 ? 42.29120 -46.20837 -16.62806 1.000 22.46014 ? 99  CYS B N   1 
ATOM   1754 C  CA  . CYS B 1 101 ? 43.34973 -47.04284 -16.07314 1.000 19.84148 ? 99  CYS B CA  1 
ATOM   1755 C  C   . CYS B 1 101 ? 43.66851 -48.21372 -16.99260 1.000 23.23456 ? 99  CYS B C   1 
ATOM   1756 O  O   . CYS B 1 101 ? 42.81964 -48.67724 -17.76130 1.000 22.69345 ? 99  CYS B O   1 
ATOM   1757 C  CB  . CYS B 1 101 ? 42.96019 -47.58141 -14.70338 1.000 20.07616 ? 99  CYS B CB  1 
ATOM   1758 S  SG  . CYS B 1 101 ? 42.47904 -46.30265 -13.51223 1.000 21.34095 ? 99  CYS B SG  1 
ATOM   1759 N  N   . ALA B 1 102 ? 44.91287 -48.68911 -16.89251 1.000 25.84739 ? 100 ALA B N   1 
ATOM   1760 C  CA  . ALA B 1 102 ? 45.30930 -49.92383 -17.54995 1.000 26.82160 ? 100 ALA B CA  1 
ATOM   1761 C  C   . ALA B 1 102 ? 44.53922 -51.11088 -16.97379 1.000 23.50666 ? 100 ALA B C   1 
ATOM   1762 O  O   . ALA B 1 102 ? 44.24532 -51.15174 -15.77591 1.000 21.97601 ? 100 ALA B O   1 
ATOM   1763 C  CB  . ALA B 1 102 ? 46.80951 -50.16586 -17.37593 1.000 25.04574 ? 100 ALA B CB  1 
ATOM   1764 N  N   . PRO B 1 103 ? 44.23496 -52.11711 -17.80465 1.000 25.28546 ? 101 PRO B N   1 
ATOM   1765 C  CA  . PRO B 1 103 ? 43.55417 -53.31189 -17.28015 1.000 27.79004 ? 101 PRO B CA  1 
ATOM   1766 C  C   . PRO B 1 103 ? 44.22004 -53.88629 -16.03754 1.000 27.09278 ? 101 PRO B C   1 
ATOM   1767 O  O   . PRO B 1 103 ? 43.53872 -54.30323 -15.09071 1.000 25.63816 ? 101 PRO B O   1 
ATOM   1768 C  CB  . PRO B 1 103 ? 43.61825 -54.28613 -18.46150 1.000 25.29033 ? 101 PRO B CB  1 
ATOM   1769 C  CG  . PRO B 1 103 ? 43.68705 -53.43234 -19.67114 1.000 28.88674 ? 101 PRO B CG  1 
ATOM   1770 C  CD  . PRO B 1 103 ? 44.30696 -52.10800 -19.27758 1.000 26.12092 ? 101 PRO B CD  1 
ATOM   1771 N  N   . ASP B 1 104 ? 45.55091 -53.88457 -15.99795 1.000 27.81794 ? 102 ASP B N   1 
ATOM   1772 C  CA  . ASP B 1 104 ? 46.27504 -54.54197 -14.92376 1.000 30.82999 ? 102 ASP B CA  1 
ATOM   1773 C  C   . ASP B 1 104 ? 46.57710 -53.61586 -13.74203 1.000 31.26278 ? 102 ASP B C   1 
ATOM   1774 O  O   . ASP B 1 104 ? 47.30096 -54.01545 -12.82279 1.000 29.31859 ? 102 ASP B O   1 
ATOM   1775 C  CB  . ASP B 1 104 ? 47.56662 -55.13484 -15.49340 1.000 34.03814 ? 102 ASP B CB  1 
ATOM   1776 C  CG  . ASP B 1 104 ? 47.31650 -56.41601 -16.27149 1.000 36.93534 ? 102 ASP B CG  1 
ATOM   1777 O  OD1 . ASP B 1 104 ? 46.21142 -56.99220 -16.14935 1.000 36.77875 ? 102 ASP B OD1 1 
ATOM   1778 O  OD2 . ASP B 1 104 ? 48.20447 -56.82125 -17.05144 1.000 47.42415 ? 102 ASP B OD2 1 
ATOM   1779 N  N   . MET B 1 105 ? 46.02455 -52.40632 -13.71384 1.000 29.28501 ? 103 MET B N   1 
ATOM   1780 C  CA  . MET B 1 105 ? 46.38513 -51.50335 -12.62549 1.000 25.52473 ? 103 MET B CA  1 
ATOM   1781 C  C   . MET B 1 105 ? 45.83453 -52.04861 -11.30691 1.000 23.57529 ? 103 MET B C   1 
ATOM   1782 O  O   . MET B 1 105 ? 44.65192 -52.43574 -11.23802 1.000 22.43042 ? 103 MET B O   1 
ATOM   1783 C  CB  . MET B 1 105 ? 45.88333 -50.06970 -12.88746 1.000 24.32598 ? 103 MET B CB  1 
ATOM   1784 C  CG  . MET B 1 105 ? 46.10507 -49.17111 -11.67568 1.000 24.13707 ? 103 MET B CG  1 
ATOM   1785 S  SD  . MET B 1 105 ? 45.22651 -47.60758 -11.70728 1.000 23.43947 ? 103 MET B SD  1 
ATOM   1786 C  CE  . MET B 1 105 ? 43.88436 -48.05947 -10.63258 1.000 22.27529 ? 103 MET B CE  1 
ATOM   1787 N  N   . PRO B 1 106 ? 46.65626 -52.13003 -10.25438 1.000 24.57499 ? 104 PRO B N   1 
ATOM   1788 C  CA  . PRO B 1 106 ? 46.20909 -52.73517 -8.99509  1.000 23.26603 ? 104 PRO B CA  1 
ATOM   1789 C  C   . PRO B 1 106 ? 45.17890 -51.90215 -8.25272  1.000 26.60188 ? 104 PRO B C   1 
ATOM   1790 O  O   . PRO B 1 106 ? 45.23015 -50.66854 -8.23210  1.000 25.42365 ? 104 PRO B O   1 
ATOM   1791 C  CB  . PRO B 1 106 ? 47.49398 -52.84494 -8.16302  1.000 25.86245 ? 104 PRO B CB  1 
ATOM   1792 C  CG  . PRO B 1 106 ? 48.56896 -52.22081 -8.93829  1.000 27.24405 ? 104 PRO B CG  1 
ATOM   1793 C  CD  . PRO B 1 106 ? 48.05182 -51.65649 -10.20039 1.000 27.16763 ? 104 PRO B CD  1 
ATOM   1794 N  N   . VAL B 1 107 ? 44.26097 -52.61502 -7.60509  1.000 26.66089 ? 105 VAL B N   1 
ATOM   1795 C  CA  . VAL B 1 107 ? 43.20410 -52.04346 -6.78052  1.000 25.78058 ? 105 VAL B CA  1 
ATOM   1796 C  C   . VAL B 1 107 ? 43.22951 -52.75091 -5.43111  1.000 28.07430 ? 105 VAL B C   1 
ATOM   1797 O  O   . VAL B 1 107 ? 43.24431 -53.98527 -5.37490  1.000 27.00137 ? 105 VAL B O   1 
ATOM   1798 C  CB  . VAL B 1 107 ? 41.82023 -52.18876 -7.45480  1.000 20.21428 ? 105 VAL B CB  1 
ATOM   1799 C  CG1 . VAL B 1 107 ? 40.70888 -51.64071 -6.54941  1.000 25.22851 ? 105 VAL B CG1 1 
ATOM   1800 C  CG2 . VAL B 1 107 ? 41.82630 -51.51054 -8.81418  1.000 23.47265 ? 105 VAL B CG2 1 
ATOM   1801 N  N   . THR B 1 108 ? 43.25231 -51.97438 -4.35248  1.000 20.75825 ? 106 THR B N   1 
ATOM   1802 C  CA  . THR B 1 108 ? 43.18307 -52.48618 -2.98802  1.000 25.08927 ? 106 THR B CA  1 
ATOM   1803 C  C   . THR B 1 108 ? 41.86985 -52.06793 -2.34416  1.000 25.63015 ? 106 THR B C   1 
ATOM   1804 O  O   . THR B 1 108 ? 41.58282 -50.87065 -2.24086  1.000 25.45126 ? 106 THR B O   1 
ATOM   1805 C  CB  . THR B 1 108 ? 44.36097 -51.98203 -2.15022  1.000 26.00919 ? 106 THR B CB  1 
ATOM   1806 O  OG1 . THR B 1 108 ? 45.58638 -52.38530 -2.76648  1.000 26.32154 ? 106 THR B OG1 1 
ATOM   1807 C  CG2 . THR B 1 108 ? 44.28109 -52.50718 -0.72719  1.000 26.70450 ? 106 THR B CG2 1 
ATOM   1808 N  N   . LEU B 1 109 ? 41.09877 -53.05416 -1.88954  1.000 23.30465 ? 107 LEU B N   1 
ATOM   1809 C  CA  . LEU B 1 109 ? 39.81651 -52.85228 -1.23619  1.000 24.01073 ? 107 LEU B CA  1 
ATOM   1810 C  C   . LEU B 1 109 ? 39.96428 -53.10131 0.25842   1.000 28.20455 ? 107 LEU B C   1 
ATOM   1811 O  O   . LEU B 1 109 ? 40.58552 -54.08499 0.67258   1.000 31.72530 ? 107 LEU B O   1 
ATOM   1812 C  CB  . LEU B 1 109 ? 38.76394 -53.79275 -1.83728  1.000 24.51893 ? 107 LEU B CB  1 
ATOM   1813 C  CG  . LEU B 1 109 ? 38.67461 -53.72203 -3.36675  1.000 25.12309 ? 107 LEU B CG  1 
ATOM   1814 C  CD1 . LEU B 1 109 ? 37.65796 -54.72293 -3.90831  1.000 22.91653 ? 107 LEU B CD1 1 
ATOM   1815 C  CD2 . LEU B 1 109 ? 38.30991 -52.29708 -3.82545  1.000 23.31532 ? 107 LEU B CD2 1 
ATOM   1816 N  N   . VAL B 1 110 ? 39.38986 -52.21654 1.06763   1.000 25.94085 ? 108 VAL B N   1 
ATOM   1817 C  CA  . VAL B 1 110 ? 39.57745 -52.23042 2.51396   1.000 27.55887 ? 108 VAL B CA  1 
ATOM   1818 C  C   . VAL B 1 110 ? 38.22922 -52.21003 3.22010   1.000 31.50306 ? 108 VAL B C   1 
ATOM   1819 O  O   . VAL B 1 110 ? 37.29706 -51.51875 2.79521   1.000 26.55956 ? 108 VAL B O   1 
ATOM   1820 C  CB  . VAL B 1 110 ? 40.44376 -51.03919 2.97764   1.000 27.96640 ? 108 VAL B CB  1 
ATOM   1821 C  CG1 . VAL B 1 110 ? 40.81574 -51.17157 4.46313   1.000 32.45581 ? 108 VAL B CG1 1 
ATOM   1822 C  CG2 . VAL B 1 110 ? 41.69403 -50.93247 2.11863   1.000 29.38531 ? 108 VAL B CG2 1 
ATOM   1823 N  N   . GLY B 1 111 ? 38.13378 -52.96135 4.31307   1.000 28.35235 ? 109 GLY B N   1 
ATOM   1824 C  CA  . GLY B 1 111 ? 36.97451 -52.90009 5.17831   1.000 28.66172 ? 109 GLY B CA  1 
ATOM   1825 C  C   . GLY B 1 111 ? 37.37237 -52.54663 6.59513   1.000 34.05936 ? 109 GLY B C   1 
ATOM   1826 O  O   . GLY B 1 111 ? 38.47231 -52.02995 6.82786   1.000 32.18002 ? 109 GLY B O   1 
ATOM   1827 N  N   . ASP B 1 112 ? 36.48874 -52.81913 7.54810   1.000 32.39538 ? 110 ASP B N   1 
ATOM   1828 C  CA  . ASP B 1 112 ? 36.79162 -52.52669 8.93820   1.000 34.35808 ? 110 ASP B CA  1 
ATOM   1829 C  C   . ASP B 1 112 ? 37.78358 -53.55418 9.48072   1.000 37.37386 ? 110 ASP B C   1 
ATOM   1830 O  O   . ASP B 1 112 ? 37.92841 -54.65905 8.94467   1.000 33.33187 ? 110 ASP B O   1 
ATOM   1831 C  CB  . ASP B 1 112 ? 35.51099 -52.52719 9.77365   1.000 34.65285 ? 110 ASP B CB  1 
ATOM   1832 C  CG  . ASP B 1 112 ? 34.78332 -51.18759 9.73481   1.000 34.40845 ? 110 ASP B CG  1 
ATOM   1833 O  OD1 . ASP B 1 112 ? 35.44871 -50.14146 9.56101   1.000 34.09759 ? 110 ASP B OD1 1 
ATOM   1834 O  OD2 . ASP B 1 112 ? 33.54153 -51.18245 9.87485   1.000 36.62328 ? 110 ASP B OD2 1 
ATOM   1835 N  N   . ASN B 1 113 ? 38.48665 -53.16479 10.54733  1.000 38.09058 ? 111 ASN B N   1 
ATOM   1836 C  CA  . ASN B 1 113 ? 39.39965 -54.06615 11.26148  1.000 41.44859 ? 111 ASN B CA  1 
ATOM   1837 C  C   . ASN B 1 113 ? 40.43996 -54.68454 10.32660  1.000 39.21015 ? 111 ASN B C   1 
ATOM   1838 O  O   . ASN B 1 113 ? 40.80099 -55.85799 10.45036  1.000 41.07891 ? 111 ASN B O   1 
ATOM   1839 C  CB  . ASN B 1 113 ? 38.62004 -55.15463 12.00078  1.000 40.57917 ? 111 ASN B CB  1 
ATOM   1840 C  CG  . ASN B 1 113 ? 37.69842 -54.58804 13.06057  1.000 45.73701 ? 111 ASN B CG  1 
ATOM   1841 O  OD1 . ASN B 1 113 ? 38.05177 -53.63990 13.76446  1.000 54.23447 ? 111 ASN B OD1 1 
ATOM   1842 N  ND2 . ASN B 1 113 ? 36.50176 -55.15840 13.17409  1.000 51.04060 ? 111 ASN B ND2 1 
ATOM   1843 N  N   . GLY B 1 114 ? 40.90529 -53.89290 9.36253   1.000 38.02427 ? 112 GLY B N   1 
ATOM   1844 C  CA  . GLY B 1 114 ? 42.06010 -54.25051 8.56099   1.000 38.89418 ? 112 GLY B CA  1 
ATOM   1845 C  C   . GLY B 1 114 ? 41.87473 -55.31842 7.50715   1.000 36.59879 ? 112 GLY B C   1 
ATOM   1846 O  O   . GLY B 1 114 ? 42.87140 -55.76577 6.93050   1.000 34.67003 ? 112 GLY B O   1 
ATOM   1847 N  N   . VAL B 1 115 ? 40.64649 -55.75018 7.21708   1.000 37.46240 ? 113 VAL B N   1 
ATOM   1848 C  CA  . VAL B 1 115 ? 40.46658 -56.70529 6.12892   1.000 34.61481 ? 113 VAL B CA  1 
ATOM   1849 C  C   . VAL B 1 115 ? 40.73863 -56.01049 4.79912   1.000 33.34338 ? 113 VAL B C   1 
ATOM   1850 O  O   . VAL B 1 115 ? 40.35048 -54.85050 4.59359   1.000 35.54391 ? 113 VAL B O   1 
ATOM   1851 C  CB  . VAL B 1 115 ? 39.06264 -57.33523 6.17923   1.000 36.20991 ? 113 VAL B CB  1 
ATOM   1852 C  CG1 . VAL B 1 115 ? 38.84277 -58.03496 7.52120   1.000 39.48917 ? 113 VAL B CG1 1 
ATOM   1853 C  CG2 . VAL B 1 115 ? 37.97192 -56.28603 5.96228   1.000 33.29686 ? 113 VAL B CG2 1 
ATOM   1854 N  N   . THR B 1 116 ? 41.44844 -56.69930 3.90181   1.000 32.75271 ? 114 THR B N   1 
ATOM   1855 C  CA  . THR B 1 116 ? 41.80563 -56.14395 2.60008   1.000 34.82280 ? 114 THR B CA  1 
ATOM   1856 C  C   . THR B 1 116 ? 41.65739 -57.21051 1.52167   1.000 38.56274 ? 114 THR B C   1 
ATOM   1857 O  O   . THR B 1 116 ? 41.61058 -58.41274 1.79961   1.000 38.94718 ? 114 THR B O   1 
ATOM   1858 C  CB  . THR B 1 116 ? 43.24456 -55.57365 2.55503   1.000 36.50205 ? 114 THR B CB  1 
ATOM   1859 O  OG1 . THR B 1 116 ? 44.19986 -56.62254 2.75731   1.000 43.46830 ? 114 THR B OG1 1 
ATOM   1860 C  CG2 . THR B 1 116 ? 43.45714 -54.50825 3.61511   1.000 36.72874 ? 114 THR B CG2 1 
ATOM   1861 N  N   . LYS B 1 117 ? 41.57953 -56.74993 0.27469   1.000 30.17228 ? 115 LYS B N   1 
ATOM   1862 C  CA  . LYS B 1 117 ? 41.50329 -57.63671 -0.87796  1.000 31.05344 ? 115 LYS B CA  1 
ATOM   1863 C  C   . LYS B 1 117 ? 42.18847 -56.95286 -2.04752  1.000 31.61347 ? 115 LYS B C   1 
ATOM   1864 O  O   . LYS B 1 117 ? 41.91809 -55.78010 -2.33024  1.000 31.48799 ? 115 LYS B O   1 
ATOM   1865 C  CB  . LYS B 1 117 ? 40.04813 -57.98730 -1.21955  1.000 33.97088 ? 115 LYS B CB  1 
ATOM   1866 C  CG  . LYS B 1 117 ? 39.83142 -58.37975 -2.66438  1.000 31.79792 ? 115 LYS B CG  1 
ATOM   1867 C  CD  . LYS B 1 117 ? 38.38064 -58.81196 -2.91558  1.000 36.42633 ? 115 LYS B CD  1 
ATOM   1868 C  CE  . LYS B 1 117 ? 38.19619 -59.27050 -4.35722  1.000 35.72455 ? 115 LYS B CE  1 
ATOM   1869 N  NZ  . LYS B 1 117 ? 38.43023 -60.72979 -4.54285  1.000 39.28768 ? 115 LYS B NZ  1 
ATOM   1870 N  N   . ALA B 1 118 ? 43.09210 -57.67256 -2.70334  1.000 28.77100 ? 116 ALA B N   1 
ATOM   1871 C  CA  . ALA B 1 118 ? 43.84626 -57.14544 -3.83129  1.000 27.45477 ? 116 ALA B CA  1 
ATOM   1872 C  C   . ALA B 1 118 ? 43.21008 -57.61750 -5.12698  1.000 31.03764 ? 116 ALA B C   1 
ATOM   1873 O  O   . ALA B 1 118 ? 42.86532 -58.79709 -5.26333  1.000 31.60511 ? 116 ALA B O   1 
ATOM   1874 C  CB  . ALA B 1 118 ? 45.31079 -57.58486 -3.77633  1.000 28.19529 ? 116 ALA B CB  1 
ATOM   1875 N  N   . THR B 1 119 ? 43.05266 -56.69949 -6.07179  1.000 27.66098 ? 117 THR B N   1 
ATOM   1876 C  CA  . THR B 1 119 ? 42.48013 -57.02291 -7.36973  1.000 26.16145 ? 117 THR B CA  1 
ATOM   1877 C  C   . THR B 1 119 ? 43.03977 -56.02786 -8.38198  1.000 27.38125 ? 117 THR B C   1 
ATOM   1878 O  O   . THR B 1 119 ? 44.01203 -55.31860 -8.10159  1.000 27.42960 ? 117 THR B O   1 
ATOM   1879 C  CB  . THR B 1 119 ? 40.94252 -57.04615 -7.26984  1.000 29.40471 ? 117 THR B CB  1 
ATOM   1880 O  OG1 . THR B 1 119 ? 40.37227 -57.50412 -8.50043  1.000 27.99459 ? 117 THR B OG1 1 
ATOM   1881 C  CG2 . THR B 1 119 ? 40.37209 -55.67102 -6.88669  1.000 25.64603 ? 117 THR B CG2 1 
ATOM   1882 N  N   . THR B 1 120 ? 42.45825 -56.00898 -9.58347  1.000 25.10489 ? 118 THR B N   1 
ATOM   1883 C  CA  . THR B 1 120 ? 42.88011 -55.12450 -10.65928 1.000 23.58601 ? 118 THR B CA  1 
ATOM   1884 C  C   . THR B 1 120 ? 41.63959 -54.61339 -11.37690 1.000 25.86347 ? 118 THR B C   1 
ATOM   1885 O  O   . THR B 1 120 ? 40.54184 -55.15572 -11.21506 1.000 24.83172 ? 118 THR B O   1 
ATOM   1886 C  CB  . THR B 1 120 ? 43.76742 -55.81813 -11.69744 1.000 28.17628 ? 118 THR B CB  1 
ATOM   1887 O  OG1 . THR B 1 120 ? 42.99715 -56.82054 -12.37273 1.000 28.25394 ? 118 THR B OG1 1 
ATOM   1888 C  CG2 . THR B 1 120 ? 44.99092 -56.46791 -11.03657 1.000 27.83073 ? 118 THR B CG2 1 
ATOM   1889 N  N   . VAL B 1 121 ? 41.84254 -53.58523 -12.20478 1.000 23.81898 ? 119 VAL B N   1 
ATOM   1890 C  CA  . VAL B 1 121 ? 40.75536 -53.02023 -13.01188 1.000 23.56459 ? 119 VAL B CA  1 
ATOM   1891 C  C   . VAL B 1 121 ? 40.09907 -54.09988 -13.87498 1.000 27.54518 ? 119 VAL B C   1 
ATOM   1892 O  O   . VAL B 1 121 ? 38.86553 -54.20369 -13.93679 1.000 25.05929 ? 119 VAL B O   1 
ATOM   1893 C  CB  . VAL B 1 121 ? 41.28752 -51.85019 -13.86406 1.000 25.37597 ? 119 VAL B CB  1 
ATOM   1894 C  CG1 . VAL B 1 121 ? 40.23974 -51.35443 -14.86297 1.000 24.02725 ? 119 VAL B CG1 1 
ATOM   1895 C  CG2 . VAL B 1 121 ? 41.75109 -50.71235 -12.95615 1.000 22.94775 ? 119 VAL B CG2 1 
ATOM   1896 N  N   . ARG B 1 122 ? 40.91107 -54.93245 -14.54084 1.000 26.93692 ? 120 ARG B N   1 
ATOM   1897 C  CA  . ARG B 1 122 ? 40.36341 -55.93688 -15.45762 1.000 29.33773 ? 120 ARG B CA  1 
ATOM   1898 C  C   . ARG B 1 122 ? 39.60915 -57.03559 -14.71946 1.000 27.25870 ? 120 ARG B C   1 
ATOM   1899 O  O   . ARG B 1 122 ? 38.59814 -57.53732 -15.22905 1.000 28.06125 ? 120 ARG B O   1 
ATOM   1900 C  CB  . ARG B 1 122 ? 41.47392 -56.55805 -16.31827 1.000 32.04471 ? 120 ARG B CB  1 
ATOM   1901 C  CG  . ARG B 1 122 ? 41.04970 -56.94355 -17.75459 1.000 35.97613 ? 120 ARG B CG  1 
ATOM   1902 C  CD  . ARG B 1 122 ? 41.20641 -58.45480 -18.08185 1.000 45.72767 ? 120 ARG B CD  1 
ATOM   1903 N  NE  . ARG B 1 122 ? 40.65121 -58.80256 -19.39563 1.000 50.88618 ? 120 ARG B NE  1 
ATOM   1904 C  CZ  . ARG B 1 122 ? 39.47216 -59.36979 -19.62904 1.000 37.30637 ? 120 ARG B CZ  1 
ATOM   1905 N  NH1 . ARG B 1 122 ? 38.73536 -59.87147 -18.65293 1.000 41.98089 ? 120 ARG B NH1 1 
ATOM   1906 N  NH2 . ARG B 1 122 ? 39.03831 -59.46723 -20.88101 1.000 41.15466 ? 120 ARG B NH2 1 
ATOM   1907 N  N   . GLU B 1 123 ? 40.09989 -57.46706 -13.54722 1.000 25.40238 ? 121 GLU B N   1 
ATOM   1908 C  CA  . GLU B 1 123 ? 39.36607 -58.49611 -12.81178 1.000 28.69697 ? 121 GLU B CA  1 
ATOM   1909 C  C   . GLU B 1 123 ? 38.02684 -57.98469 -12.31329 1.000 27.94553 ? 121 GLU B C   1 
ATOM   1910 O  O   . GLU B 1 123 ? 37.06311 -58.75529 -12.23712 1.000 24.64386 ? 121 GLU B O   1 
ATOM   1911 C  CB  . GLU B 1 123 ? 40.16425 -59.05146 -11.62706 1.000 29.94561 ? 121 GLU B CB  1 
ATOM   1912 C  CG  . GLU B 1 123 ? 41.61470 -59.36677 -11.90122 1.000 34.76191 ? 121 GLU B CG  1 
ATOM   1913 C  CD  . GLU B 1 123 ? 42.27541 -60.14589 -10.77144 1.000 39.67319 ? 121 GLU B CD  1 
ATOM   1914 O  OE1 . GLU B 1 123 ? 41.75484 -60.14124 -9.62845  1.000 43.79422 ? 121 GLU B OE1 1 
ATOM   1915 O  OE2 . GLU B 1 123 ? 43.31610 -60.77452 -11.03953 1.000 44.90372 ? 121 GLU B OE2 1 
ATOM   1916 N  N   . LEU B 1 124 ? 37.94789 -56.70493 -11.95659 1.000 21.66537 ? 122 LEU B N   1 
ATOM   1917 C  CA  . LEU B 1 124 ? 36.67534 -56.16929 -11.49388 1.000 22.25214 ? 122 LEU B CA  1 
ATOM   1918 C  C   . LEU B 1 124 ? 35.69218 -55.95534 -12.64312 1.000 20.84832 ? 122 LEU B C   1 
ATOM   1919 O  O   . LEU B 1 124 ? 34.47557 -56.00534 -12.42324 1.000 21.13386 ? 122 LEU B O   1 
ATOM   1920 C  CB  . LEU B 1 124 ? 36.91309 -54.86601 -10.72906 1.000 21.02281 ? 122 LEU B CB  1 
ATOM   1921 C  CG  . LEU B 1 124 ? 37.56001 -54.92299 -9.34005  1.000 23.83687 ? 122 LEU B CG  1 
ATOM   1922 C  CD1 . LEU B 1 124 ? 37.90214 -53.51703 -8.86166  1.000 24.51203 ? 122 LEU B CD1 1 
ATOM   1923 C  CD2 . LEU B 1 124 ? 36.69633 -55.63543 -8.30076  1.000 21.48308 ? 122 LEU B CD2 1 
ATOM   1924 N  N   . LEU B 1 125 ? 36.17937 -55.73196 -13.85995 1.000 20.93226 ? 123 LEU B N   1 
ATOM   1925 C  CA  . LEU B 1 125 ? 35.31430 -55.46067 -15.01280 1.000 22.68324 ? 123 LEU B CA  1 
ATOM   1926 C  C   . LEU B 1 125 ? 35.80215 -56.25329 -16.21858 1.000 22.70449 ? 123 LEU B C   1 
ATOM   1927 O  O   . LEU B 1 125 ? 36.40545 -55.70463 -17.15394 1.000 20.70456 ? 123 LEU B O   1 
ATOM   1928 C  CB  . LEU B 1 125 ? 35.23843 -53.95592 -15.30951 1.000 18.84645 ? 123 LEU B CB  1 
ATOM   1929 C  CG  . LEU B 1 125 ? 34.07510 -53.52322 -16.21057 1.000 21.44511 ? 123 LEU B CG  1 
ATOM   1930 C  CD1 . LEU B 1 125 ? 32.72640 -53.66553 -15.49286 1.000 20.78972 ? 123 LEU B CD1 1 
ATOM   1931 C  CD2 . LEU B 1 125 ? 34.26727 -52.10077 -16.73037 1.000 22.55804 ? 123 LEU B CD2 1 
ATOM   1932 N  N   . PRO B 1 126 ? 35.51821 -57.56163 -16.24198 1.000 21.41241 ? 124 PRO B N   1 
ATOM   1933 C  CA  . PRO B 1 126 ? 35.92069 -58.39878 -17.38094 1.000 27.28107 ? 124 PRO B CA  1 
ATOM   1934 C  C   . PRO B 1 126 ? 35.20739 -57.97419 -18.65059 1.000 25.67506 ? 124 PRO B C   1 
ATOM   1935 O  O   . PRO B 1 126 ? 34.08605 -57.46473 -18.60821 1.000 23.70143 ? 124 PRO B O   1 
ATOM   1936 C  CB  . PRO B 1 126 ? 35.47977 -59.80953 -16.96188 1.000 24.16180 ? 124 PRO B CB  1 
ATOM   1937 C  CG  . PRO B 1 126 ? 35.26333 -59.73938 -15.48396 1.000 28.50616 ? 124 PRO B CG  1 
ATOM   1938 C  CD  . PRO B 1 126 ? 34.80148 -58.32896 -15.21493 1.000 22.04781 ? 124 PRO B CD  1 
ATOM   1939 N  N   . TYR B 1 127 ? 35.86037 -58.21988 -19.78775 1.000 24.18777 ? 125 TYR B N   1 
ATOM   1940 C  CA  . TYR B 1 127 ? 35.28544 -57.96256 -21.10847 1.000 26.84300 ? 125 TYR B CA  1 
ATOM   1941 C  C   . TYR B 1 127 ? 34.73183 -56.53846 -21.17209 1.000 26.80158 ? 125 TYR B C   1 
ATOM   1942 O  O   . TYR B 1 127 ? 33.58962 -56.30499 -21.57354 1.000 23.85481 ? 125 TYR B O   1 
ATOM   1943 C  CB  . TYR B 1 127 ? 34.20549 -59.00901 -21.44262 1.000 25.27689 ? 125 TYR B CB  1 
ATOM   1944 C  CG  . TYR B 1 127 ? 33.80791 -59.08183 -22.90794 1.000 26.30430 ? 125 TYR B CG  1 
ATOM   1945 C  CD1 . TYR B 1 127 ? 34.63645 -59.69823 -23.83999 1.000 29.33062 ? 125 TYR B CD1 1 
ATOM   1946 C  CD2 . TYR B 1 127 ? 32.59212 -58.57663 -23.35315 1.000 27.52125 ? 125 TYR B CD2 1 
ATOM   1947 C  CE1 . TYR B 1 127 ? 34.29030 -59.77162 -25.17177 1.000 29.86204 ? 125 TYR B CE1 1 
ATOM   1948 C  CE2 . TYR B 1 127 ? 32.23355 -58.64534 -24.69160 1.000 25.91967 ? 125 TYR B CE2 1 
ATOM   1949 C  CZ  . TYR B 1 127 ? 33.08372 -59.25232 -25.59691 1.000 29.43546 ? 125 TYR B CZ  1 
ATOM   1950 O  OH  . TYR B 1 127 ? 32.73382 -59.32552 -26.92664 1.000 27.32800 ? 125 TYR B OH  1 
ATOM   1951 N  N   . ALA B 1 128 ? 35.56260 -55.58045 -20.75489 1.000 24.19128 ? 126 ALA B N   1 
ATOM   1952 C  CA  . ALA B 1 128 ? 35.09022 -54.21406 -20.52459 1.000 23.67441 ? 126 ALA B CA  1 
ATOM   1953 C  C   . ALA B 1 128 ? 34.62242 -53.55395 -21.81580 1.000 25.40031 ? 126 ALA B C   1 
ATOM   1954 O  O   . ALA B 1 128 ? 35.26313 -53.66708 -22.86502 1.000 22.94724 ? 126 ALA B O   1 
ATOM   1955 C  CB  . ALA B 1 128 ? 36.20080 -53.37075 -19.88114 1.000 23.43026 ? 126 ALA B CB  1 
ATOM   1956 N  N   . PHE B 1 129 ? 33.49364 -52.84740 -21.72660 1.000 23.07562 ? 127 PHE B N   1 
ATOM   1957 C  CA  . PHE B 1 129 ? 33.04181 -51.98088 -22.80574 1.000 21.02936 ? 127 PHE B CA  1 
ATOM   1958 C  C   . PHE B 1 129 ? 33.99712 -50.80260 -22.97627 1.000 28.01990 ? 127 PHE B C   1 
ATOM   1959 O  O   . PHE B 1 129 ? 34.39386 -50.17036 -21.98845 1.000 26.37709 ? 127 PHE B O   1 
ATOM   1960 C  CB  . PHE B 1 129 ? 31.62980 -51.47326 -22.49341 1.000 19.06136 ? 127 PHE B CB  1 
ATOM   1961 C  CG  . PHE B 1 129 ? 31.07266 -50.52977 -23.52500 1.000 23.84908 ? 127 PHE B CG  1 
ATOM   1962 C  CD1 . PHE B 1 129 ? 30.50675 -51.00319 -24.70337 1.000 22.84551 ? 127 PHE B CD1 1 
ATOM   1963 C  CD2 . PHE B 1 129 ? 31.11103 -49.15581 -23.31292 1.000 21.00672 ? 127 PHE B CD2 1 
ATOM   1964 C  CE1 . PHE B 1 129 ? 29.98806 -50.12868 -25.65081 1.000 23.30832 ? 127 PHE B CE1 1 
ATOM   1965 C  CE2 . PHE B 1 129 ? 30.60528 -48.27540 -24.26577 1.000 22.16377 ? 127 PHE B CE2 1 
ATOM   1966 C  CZ  . PHE B 1 129 ? 30.04119 -48.75551 -25.42971 1.000 26.44980 ? 127 PHE B CZ  1 
ATOM   1967 N  N   . THR B 1 130 ? 34.35624 -50.49806 -24.22698 1.000 24.25654 ? 128 THR B N   1 
ATOM   1968 C  CA  . THR B 1 130 ? 35.25226 -49.38591 -24.55736 1.000 26.13519 ? 128 THR B CA  1 
ATOM   1969 C  C   . THR B 1 130 ? 34.64984 -48.56696 -25.69331 1.000 27.33659 ? 128 THR B C   1 
ATOM   1970 O  O   . THR B 1 130 ? 33.58866 -48.89415 -26.23985 1.000 28.48466 ? 128 THR B O   1 
ATOM   1971 C  CB  . THR B 1 130 ? 36.64694 -49.86288 -24.98923 1.000 30.31726 ? 128 THR B CB  1 
ATOM   1972 O  OG1 . THR B 1 130 ? 36.58238 -50.31346 -26.34529 1.000 30.59823 ? 128 THR B OG1 1 
ATOM   1973 C  CG2 . THR B 1 130 ? 37.13877 -50.99971 -24.10737 1.000 26.94073 ? 128 THR B CG2 1 
ATOM   1974 N  N   . GLU B 1 131 ? 35.35725 -47.50342 -26.07986 1.000 26.63876 ? 129 GLU B N   1 
ATOM   1975 C  CA  . GLU B 1 131 ? 34.87128 -46.60933 -27.12663 1.000 26.96804 ? 129 GLU B CA  1 
ATOM   1976 C  C   . GLU B 1 131 ? 35.15261 -47.11372 -28.53828 1.000 28.94872 ? 129 GLU B C   1 
ATOM   1977 O  O   . GLU B 1 131 ? 34.84016 -46.39829 -29.49607 1.000 27.55062 ? 129 GLU B O   1 
ATOM   1978 C  CB  . GLU B 1 131 ? 35.51446 -45.22905 -26.99675 1.000 31.46152 ? 129 GLU B CB  1 
ATOM   1979 C  CG  . GLU B 1 131 ? 37.03209 -45.21936 -27.19817 1.000 29.98834 ? 129 GLU B CG  1 
ATOM   1980 C  CD  . GLU B 1 131 ? 37.82474 -45.65475 -25.97622 1.000 35.33235 ? 129 GLU B CD  1 
ATOM   1981 O  OE1 . GLU B 1 131 ? 37.28889 -46.38743 -25.11003 1.000 38.41277 ? 129 GLU B OE1 1 
ATOM   1982 O  OE2 . GLU B 1 131 ? 38.99658 -45.22819 -25.86574 1.000 47.23265 ? 129 GLU B OE2 1 
ATOM   1983 N  N   . LYS B 1 132 ? 35.70514 -48.32099 -28.69342 1.000 32.63368 ? 130 LYS B N   1 
ATOM   1984 C  CA  . LYS B 1 132 ? 36.34826 -48.67438 -29.95796 1.000 33.23226 ? 130 LYS B CA  1 
ATOM   1985 C  C   . LYS B 1 132 ? 35.38409 -48.66235 -31.14673 1.000 34.40997 ? 130 LYS B C   1 
ATOM   1986 O  O   . LYS B 1 132 ? 35.80558 -48.36473 -32.27119 1.000 35.86489 ? 130 LYS B O   1 
ATOM   1987 C  CB  . LYS B 1 132 ? 37.05065 -50.03275 -29.83607 1.000 34.74713 ? 130 LYS B CB  1 
ATOM   1988 C  CG  . LYS B 1 132 ? 36.19463 -51.19704 -29.39949 1.000 35.35207 ? 130 LYS B CG  1 
ATOM   1989 C  CD  . LYS B 1 132 ? 36.95369 -52.50732 -29.66838 1.000 37.79513 ? 130 LYS B CD  1 
ATOM   1990 C  CE  . LYS B 1 132 ? 36.61138 -53.63929 -28.69500 1.000 40.41349 ? 130 LYS B CE  1 
ATOM   1991 N  NZ  . LYS B 1 132 ? 36.36293 -53.20330 -27.28853 1.000 42.32801 ? 130 LYS B NZ  1 
ATOM   1992 N  N   . ASP B 1 133 ? 34.09633 -48.94307 -30.93358 1.000 32.67654 ? 131 ASP B N   1 
ATOM   1993 C  CA  . ASP B 1 133 ? 33.14354 -49.04821 -32.03433 1.000 29.79061 ? 131 ASP B CA  1 
ATOM   1994 C  C   . ASP B 1 133 ? 32.25080 -47.82256 -32.19738 1.000 30.66800 ? 131 ASP B C   1 
ATOM   1995 O  O   . ASP B 1 133 ? 31.34439 -47.84058 -33.03859 1.000 30.43767 ? 131 ASP B O   1 
ATOM   1996 C  CB  . ASP B 1 133 ? 32.27986 -50.29939 -31.86428 1.000 30.16420 ? 131 ASP B CB  1 
ATOM   1997 C  CG  . ASP B 1 133 ? 33.10185 -51.56916 -31.88603 1.000 34.25231 ? 131 ASP B CG  1 
ATOM   1998 O  OD1 . ASP B 1 133 ? 33.95119 -51.70037 -32.79636 1.000 35.06439 ? 131 ASP B OD1 1 
ATOM   1999 O  OD2 . ASP B 1 133 ? 32.92572 -52.41945 -30.98747 1.000 31.73376 ? 131 ASP B OD2 1 
ATOM   2000 N  N   . LEU B 1 134 ? 32.48542 -46.75904 -31.43443 1.000 30.50827 ? 132 LEU B N   1 
ATOM   2001 C  CA  . LEU B 1 134 ? 31.63046 -45.57708 -31.50977 1.000 29.84550 ? 132 LEU B CA  1 
ATOM   2002 C  C   . LEU B 1 134 ? 31.76806 -44.87030 -32.85925 1.000 37.21302 ? 132 LEU B C   1 
ATOM   2003 O  O   . LEU B 1 134 ? 32.84875 -44.87058 -33.46091 1.000 39.41327 ? 132 LEU B O   1 
ATOM   2004 C  CB  . LEU B 1 134 ? 31.96758 -44.60737 -30.37222 1.000 30.55106 ? 132 LEU B CB  1 
ATOM   2005 C  CG  . LEU B 1 134 ? 31.59850 -45.13412 -28.98406 1.000 28.27550 ? 132 LEU B CG  1 
ATOM   2006 C  CD1 . LEU B 1 134 ? 31.88566 -44.09319 -27.89512 1.000 27.53938 ? 132 LEU B CD1 1 
ATOM   2007 C  CD2 . LEU B 1 134 ? 30.13732 -45.63273 -28.92922 1.000 26.72625 ? 132 LEU B CD2 1 
ATOM   2008 O  OXT . LEU B 1 134 ? 30.81303 -44.27691 -33.37892 1.000 35.97956 ? 132 LEU B OXT 1 
HETATM 2009 ZN ZN  . ZN  C 2 .   ? 25.08048 -30.75152 -16.26582 1.000 16.94894 ? 201 ZN  A ZN  1 
HETATM 2010 N  N1  . Y7U D 3 .   ? 27.67765 -30.62164 -20.12005 0.969 18.53705 ? 202 Y7U A N1  1 
HETATM 2011 C  C2  . Y7U D 3 .   ? 26.33503 -30.57096 -20.41125 0.986 21.43077 ? 202 Y7U A C2  1 
HETATM 2012 O  O3  . Y7U D 3 .   ? 26.48724 -33.41433 -23.08931 1.000 23.57867 ? 202 Y7U A O3  1 
HETATM 2013 C  C4  . Y7U D 3 .   ? 25.89407 -29.35739 -18.38637 0.726 24.68958 ? 202 Y7U A C4  1 
HETATM 2014 C  C5  . Y7U D 3 .   ? 28.60719 -31.39307 -20.97044 0.739 23.23342 ? 202 Y7U A C5  1 
HETATM 2015 C  C6  . Y7U D 3 .   ? 28.49021 -32.88749 -20.68082 0.588 23.60127 ? 202 Y7U A C6  1 
HETATM 2016 C  C7  . Y7U D 3 .   ? 29.02033 -33.53004 -21.96044 1.000 19.71495 ? 202 Y7U A C7  1 
HETATM 2017 C  C9  . Y7U D 3 .   ? 27.55196 -32.97081 -23.92145 1.000 24.36653 ? 202 Y7U A C9  1 
HETATM 2018 C  C1  . Y7U D 3 .   ? 25.44239 -29.97243 -19.60502 0.901 31.65496 ? 202 Y7U A C1  1 
HETATM 2019 C  C3  . Y7U D 3 .   ? 28.18593 -30.06738 -18.95724 0.609 28.08814 ? 202 Y7U A C3  1 
HETATM 2020 C  C8  . Y7U D 3 .   ? 28.67587 -32.49062 -23.03225 1.000 18.36931 ? 202 Y7U A C8  1 
HETATM 2021 F  F1  . Y7U D 3 .   ? 29.07971 -33.30897 -19.52304 0.978 18.33667 ? 202 Y7U A F1  1 
HETATM 2022 F  F2  . Y7U D 3 .   ? 27.16998 -33.20506 -20.52253 0.925 26.65676 ? 202 Y7U A F2  1 
HETATM 2023 N  N2  . Y7U D 3 .   ? 27.25247 -29.44583 -18.16788 0.811 25.71273 ? 202 Y7U A N2  1 
HETATM 2024 O  O1  . Y7U D 3 .   ? 29.36671 -30.09067 -18.64600 1.000 32.13273 ? 202 Y7U A O1  1 
HETATM 2025 O  O2  . Y7U D 3 .   ? 28.23188 -31.29811 -22.33282 0.870 20.69338 ? 202 Y7U A O2  1 
HETATM 2026 O  O4  . Y7U D 3 .   ? 30.40739 -33.74096 -21.83203 0.921 20.58052 ? 202 Y7U A O4  1 
HETATM 2027 O  O5  . Y7U D 3 .   ? 25.19628 -28.77857 -17.54922 0.947 19.79946 ? 202 Y7U A O5  1 
HETATM 2028 ZN ZN  . ZN  E 2 .   ? 30.39285 -46.60061 -7.40250  1.000 18.97856 ? 201 ZN  B ZN  1 
HETATM 2029 N  N1  . Y7U F 3 .   ? 29.04339 -45.93095 -2.82531  0.913 18.70540 ? 202 Y7U B N1  1 
HETATM 2030 C  C2  . Y7U F 3 .   ? 28.48536 -47.07911 -3.33695  0.981 20.24359 ? 202 Y7U B C2  1 
HETATM 2031 O  O3  . Y7U F 3 .   ? 24.95450 -46.40252 -2.29601  1.000 20.04180 ? 202 Y7U B O3  1 
HETATM 2032 C  C4  . Y7U F 3 .   ? 30.40668 -47.44905 -4.72883  0.848 21.88470 ? 202 Y7U B C4  1 
HETATM 2033 C  C5  . Y7U F 3 .   ? 28.28668 -45.05121 -1.91507  0.965 17.73456 ? 202 Y7U B C5  1 
HETATM 2034 C  C6  . Y7U F 3 .   ? 27.31015 -44.18337 -2.71661  0.933 20.00952 ? 202 Y7U B C6  1 
HETATM 2035 C  C7  . Y7U F 3 .   ? 26.19196 -43.89501 -1.72170  0.963 19.03645 ? 202 Y7U B C7  1 
HETATM 2036 C  C9  . Y7U F 3 .   ? 25.05445 -46.03729 -0.92611  1.000 18.96265 ? 202 Y7U B C9  1 
HETATM 2037 C  C1  . Y7U F 3 .   ? 29.10787 -47.83668 -4.25486  0.982 21.67750 ? 202 Y7U B C1  1 
HETATM 2038 C  C3  . Y7U F 3 .   ? 30.28778 -45.49098 -3.23997  0.837 21.47599 ? 202 Y7U B C3  1 
HETATM 2039 C  C8  . Y7U F 3 .   ? 26.23409 -45.10445 -0.77609  0.988 19.50487 ? 202 Y7U B C8  1 
HETATM 2040 F  F1  . Y7U F 3 .   ? 27.85702 -43.10305 -3.34802  0.958 18.18288 ? 202 Y7U B F1  1 
HETATM 2041 F  F2  . Y7U F 3 .   ? 26.81891 -44.88936 -3.77883  0.969 20.80339 ? 202 Y7U B F2  1 
HETATM 2042 N  N2  . Y7U F 3 .   ? 30.90353 -46.29330 -4.16407  0.939 21.90442 ? 202 Y7U B N2  1 
HETATM 2043 O  O1  . Y7U F 3 .   ? 30.81864 -44.47336 -2.81998  0.915 21.01194 ? 202 Y7U B O1  1 
HETATM 2044 O  O2  . Y7U F 3 .   ? 27.44312 -45.83441 -1.09078  0.909 20.61858 ? 202 Y7U B O2  1 
HETATM 2045 O  O4  . Y7U F 3 .   ? 26.45951 -42.71222 -0.99070  0.965 18.61100 ? 202 Y7U B O4  1 
HETATM 2046 O  O5  . Y7U F 3 .   ? 31.07894 -48.02674 -5.58422  0.944 20.38522 ? 202 Y7U B O5  1 
HETATM 2047 O  O   . HOH G 4 .   ? 38.71339 -3.48905  -6.95552  1.000 39.11751 ? 301 HOH A O   1 
HETATM 2048 O  O   . HOH G 4 .   ? 28.29634 -17.14113 2.18321   1.000 31.95574 ? 302 HOH A O   1 
HETATM 2049 O  O   . HOH G 4 .   ? 27.75996 -18.77373 5.42721   1.000 40.02257 ? 303 HOH A O   1 
HETATM 2050 O  O   . HOH G 4 .   ? 37.49269 -33.96577 -28.36867 1.000 29.69933 ? 304 HOH A O   1 
HETATM 2051 O  O   . HOH G 4 .   ? 40.64232 -14.77084 -8.53348  1.000 46.99592 ? 305 HOH A O   1 
HETATM 2052 O  O   . HOH G 4 .   ? 26.45390 -26.64780 1.35446   1.000 25.32435 ? 306 HOH A O   1 
HETATM 2053 O  O   . HOH G 4 .   ? 38.17732 -22.90472 1.48656   1.000 30.05242 ? 307 HOH A O   1 
HETATM 2054 O  O   . HOH G 4 .   ? 39.74218 -21.48932 -23.24622 1.000 29.93195 ? 308 HOH A O   1 
HETATM 2055 O  O   . HOH G 4 .   ? 33.66995 -14.98556 -23.90791 1.000 30.68421 ? 309 HOH A O   1 
HETATM 2056 O  O   . HOH G 4 .   ? 42.97536 -31.34270 -2.78141  1.000 34.59365 ? 310 HOH A O   1 
HETATM 2057 O  O   . HOH G 4 .   ? 32.36576 -8.17868  -14.23584 1.000 39.04768 ? 311 HOH A O   1 
HETATM 2058 O  O   . HOH G 4 .   ? 31.22848 -25.85664 -25.59554 1.000 21.01195 ? 312 HOH A O   1 
HETATM 2059 O  O   . HOH G 4 .   ? 41.99120 -13.81252 -14.67999 1.000 43.52310 ? 313 HOH A O   1 
HETATM 2060 O  O   . HOH G 4 .   ? 9.75466  -33.38812 -1.09354  1.000 30.59150 ? 314 HOH A O   1 
HETATM 2061 O  O   . HOH G 4 .   ? 34.80911 -28.21777 -29.70953 1.000 33.28998 ? 315 HOH A O   1 
HETATM 2062 O  O   . HOH G 4 .   ? 39.29381 -8.87877  -13.02290 1.000 44.61667 ? 316 HOH A O   1 
HETATM 2063 O  O   . HOH G 4 .   ? 34.10491 -21.27899 -30.36126 1.000 34.18320 ? 317 HOH A O   1 
HETATM 2064 O  O   . HOH G 4 .   ? 7.51731  -21.88026 -6.99295  1.000 41.52340 ? 318 HOH A O   1 
HETATM 2065 O  O   . HOH G 4 .   ? 25.42900 -44.92989 -20.39598 1.000 19.58068 ? 319 HOH A O   1 
HETATM 2066 O  O   . HOH G 4 .   ? 26.36350 -12.42466 -13.21030 1.000 34.22680 ? 320 HOH A O   1 
HETATM 2067 O  O   . HOH G 4 .   ? 21.08263 -13.08732 -5.72719  1.000 29.70380 ? 321 HOH A O   1 
HETATM 2068 O  O   . HOH G 4 .   ? 31.10705 -22.90572 6.05411   1.000 34.27332 ? 322 HOH A O   1 
HETATM 2069 O  O   . HOH G 4 .   ? 28.51035 -15.09908 -28.76234 1.000 27.53689 ? 323 HOH A O   1 
HETATM 2070 O  O   . HOH G 4 .   ? 13.92759 -28.68669 2.57897   1.000 39.61335 ? 324 HOH A O   1 
HETATM 2071 O  O   . HOH G 4 .   ? 6.19384  -31.36234 0.19469   1.000 24.73957 ? 325 HOH A O   1 
HETATM 2072 O  O   . HOH G 4 .   ? 42.697   -25.108   0.777     1.000 33.03323 ? 326 HOH A O   1 
HETATM 2073 O  O   . HOH G 4 .   ? 40.72438 -25.56301 -6.17908  1.000 23.21889 ? 327 HOH A O   1 
HETATM 2074 O  O   . HOH G 4 .   ? 21.732   -20.052   -28.858   1.000 33.79945 ? 328 HOH A O   1 
HETATM 2075 O  O   . HOH G 4 .   ? 10.35387 -23.79103 -3.71022  1.000 35.61002 ? 329 HOH A O   1 
HETATM 2076 O  O   . HOH G 4 .   ? 18.51497 -30.95846 -0.76956  1.000 26.95664 ? 330 HOH A O   1 
HETATM 2077 O  O   . HOH G 4 .   ? 28.82596 -9.82316  -21.32370 1.000 41.93964 ? 331 HOH A O   1 
HETATM 2078 O  O   . HOH G 4 .   ? 42.34847 -32.08280 -17.87822 1.000 23.99027 ? 332 HOH A O   1 
HETATM 2079 O  O   . HOH G 4 .   ? 7.57334  -31.05817 4.41848   1.000 36.43705 ? 333 HOH A O   1 
HETATM 2080 O  O   . HOH G 4 .   ? 19.12468 -13.75332 -16.71833 1.000 32.80724 ? 334 HOH A O   1 
HETATM 2081 O  O   . HOH G 4 .   ? 16.80182 -15.65840 -6.98837  1.000 31.17024 ? 335 HOH A O   1 
HETATM 2082 O  O   . HOH G 4 .   ? 26.877   -21.421   4.885     1.000 47.58377 ? 336 HOH A O   1 
HETATM 2083 O  O   . HOH G 4 .   ? 41.62796 -33.81267 -0.31630  1.000 30.35570 ? 337 HOH A O   1 
HETATM 2084 O  O   . HOH G 4 .   ? 32.98404 -29.61869 6.15223   1.000 36.80200 ? 338 HOH A O   1 
HETATM 2085 O  O   . HOH G 4 .   ? 24.05180 -13.80305 -25.99875 1.000 35.50766 ? 339 HOH A O   1 
HETATM 2086 O  O   . HOH G 4 .   ? 19.14545 -31.67866 -4.26211  1.000 22.81620 ? 340 HOH A O   1 
HETATM 2087 O  O   . HOH G 4 .   ? 24.98240 -20.26815 -1.27609  1.000 23.50008 ? 341 HOH A O   1 
HETATM 2088 O  O   . HOH G 4 .   ? 26.29356 -40.26605 -14.35122 1.000 29.42696 ? 342 HOH A O   1 
HETATM 2089 O  O   . HOH G 4 .   ? 44.83644 -28.21149 -13.77521 1.000 35.95120 ? 343 HOH A O   1 
HETATM 2090 O  O   . HOH G 4 .   ? 13.19082 -18.65168 -13.45838 1.000 29.38878 ? 344 HOH A O   1 
HETATM 2091 O  O   . HOH G 4 .   ? 26.29154 -22.63750 0.04643   1.000 19.69304 ? 345 HOH A O   1 
HETATM 2092 O  O   . HOH G 4 .   ? 29.08994 -12.97175 -6.06031  1.000 31.60705 ? 346 HOH A O   1 
HETATM 2093 O  O   . HOH G 4 .   ? 12.24221 -25.74279 -2.75951  1.000 28.12656 ? 347 HOH A O   1 
HETATM 2094 O  O   . HOH G 4 .   ? 43.08610 -22.84202 -15.59563 1.000 29.42203 ? 348 HOH A O   1 
HETATM 2095 O  O   . HOH G 4 .   ? 26.77701 -14.56930 -3.10212  1.000 32.76206 ? 349 HOH A O   1 
HETATM 2096 O  O   . HOH G 4 .   ? 30.58490 -30.81526 -30.56399 1.000 42.34636 ? 350 HOH A O   1 
HETATM 2097 O  O   . HOH G 4 .   ? 41.38684 -16.27467 -13.38891 1.000 42.86476 ? 351 HOH A O   1 
HETATM 2098 O  O   . HOH G 4 .   ? 14.09978 -29.88860 -8.46927  1.000 13.87733 ? 352 HOH A O   1 
HETATM 2099 O  O   . HOH G 4 .   ? 39.13111 -15.40348 -20.52707 1.000 40.54440 ? 353 HOH A O   1 
HETATM 2100 O  O   . HOH G 4 .   ? 38.55350 -26.79779 -25.85579 1.000 25.25055 ? 354 HOH A O   1 
HETATM 2101 O  O   . HOH G 4 .   ? 32.81194 -23.47449 1.94241   1.000 24.74078 ? 355 HOH A O   1 
HETATM 2102 O  O   . HOH G 4 .   ? 29.78394 -40.74475 -13.38658 1.000 15.50720 ? 356 HOH A O   1 
HETATM 2103 O  O   . HOH G 4 .   ? 44.877   -28.879   -22.950   1.000 40.06785 ? 357 HOH A O   1 
HETATM 2104 O  O   . HOH G 4 .   ? 40.46667 -1.21970  -10.13089 1.000 46.75037 ? 358 HOH A O   1 
HETATM 2105 O  O   . HOH G 4 .   ? 32.90506 -39.76526 -16.34948 1.000 14.35886 ? 359 HOH A O   1 
HETATM 2106 O  O   . HOH G 4 .   ? 33.09490 -19.14466 -23.03278 1.000 24.96204 ? 360 HOH A O   1 
HETATM 2107 O  O   . HOH G 4 .   ? 6.96891  -35.01426 5.09576   1.000 35.81339 ? 361 HOH A O   1 
HETATM 2108 O  O   . HOH G 4 .   ? 35.10527 -18.62737 -24.90945 1.000 30.05958 ? 362 HOH A O   1 
HETATM 2109 O  O   . HOH G 4 .   ? 41.91799 -32.48520 -22.16581 1.000 24.98062 ? 363 HOH A O   1 
HETATM 2110 O  O   . HOH G 4 .   ? 31.57459 -4.46815  -8.63267  1.000 35.60234 ? 364 HOH A O   1 
HETATM 2111 O  O   . HOH G 4 .   ? 11.92351 -34.94548 0.02067   1.000 28.33325 ? 365 HOH A O   1 
HETATM 2112 O  O   . HOH G 4 .   ? 18.74122 -24.33052 -2.64069  1.000 28.13961 ? 366 HOH A O   1 
HETATM 2113 O  O   . HOH G 4 .   ? 22.66590 -12.93226 -10.44421 1.000 28.97550 ? 367 HOH A O   1 
HETATM 2114 O  O   . HOH G 4 .   ? 25.50082 -37.58308 -15.24981 1.000 28.84872 ? 368 HOH A O   1 
HETATM 2115 O  O   . HOH G 4 .   ? 10.93363 -35.56742 6.65689   1.000 37.59500 ? 369 HOH A O   1 
HETATM 2116 O  O   . HOH G 4 .   ? 13.52939 -23.39024 -6.01381  1.000 25.07008 ? 370 HOH A O   1 
HETATM 2117 O  O   . HOH G 4 .   ? 18.51761 -14.78495 -21.41136 1.000 37.62284 ? 371 HOH A O   1 
HETATM 2118 O  O   . HOH G 4 .   ? 37.82021 -15.86928 -5.23545  1.000 28.36564 ? 372 HOH A O   1 
HETATM 2119 O  O   . HOH G 4 .   ? 40.00019 -28.16077 3.36946   1.000 54.10642 ? 373 HOH A O   1 
HETATM 2120 O  O   . HOH G 4 .   ? 14.42959 -35.27069 5.69938   1.000 35.71375 ? 374 HOH A O   1 
HETATM 2121 O  O   . HOH G 4 .   ? 23.15791 -21.29399 -24.83989 1.000 22.44244 ? 375 HOH A O   1 
HETATM 2122 O  O   . HOH G 4 .   ? 12.47328 -19.42733 -9.40876  1.000 31.10818 ? 376 HOH A O   1 
HETATM 2123 O  O   . HOH G 4 .   ? 22.47651 -12.84955 -22.05684 1.000 45.60369 ? 377 HOH A O   1 
HETATM 2124 O  O   . HOH G 4 .   ? 29.60044 -34.03844 5.44752   1.000 27.26342 ? 378 HOH A O   1 
HETATM 2125 O  O   . HOH G 4 .   ? 41.22544 -42.21993 -21.51477 1.000 28.87220 ? 379 HOH A O   1 
HETATM 2126 O  O   . HOH G 4 .   ? 27.64689 -31.34921 5.44582   1.000 29.59174 ? 380 HOH A O   1 
HETATM 2127 O  O   . HOH G 4 .   ? 27.24398 -18.96884 1.14772   1.000 39.02617 ? 381 HOH A O   1 
HETATM 2128 O  O   . HOH G 4 .   ? 42.80041 -16.41248 -18.95014 1.000 40.07394 ? 382 HOH A O   1 
HETATM 2129 O  O   . HOH G 4 .   ? 34.70308 -41.56883 -17.30369 1.000 14.38663 ? 383 HOH A O   1 
HETATM 2130 O  O   . HOH G 4 .   ? 17.70656 -29.24080 -2.99306  1.000 24.49769 ? 384 HOH A O   1 
HETATM 2131 O  O   . HOH G 4 .   ? 11.07901 -30.92040 -1.84662  1.000 23.13936 ? 385 HOH A O   1 
HETATM 2132 O  O   . HOH G 4 .   ? 29.86796 -19.85691 -30.33308 1.000 27.53290 ? 386 HOH A O   1 
HETATM 2133 O  O   . HOH G 4 .   ? 28.734   -33.467   -30.609   1.000 46.18579 ? 387 HOH A O   1 
HETATM 2134 O  O   . HOH G 4 .   ? 42.57577 -28.07598 -2.92004  1.000 31.03172 ? 388 HOH A O   1 
HETATM 2135 O  O   . HOH G 4 .   ? 28.19448 -38.50494 -13.08926 1.000 21.74995 ? 389 HOH A O   1 
HETATM 2136 O  O   . HOH G 4 .   ? 16.88192 -23.77878 -6.93904  1.000 27.94627 ? 390 HOH A O   1 
HETATM 2137 O  O   . HOH G 4 .   ? 18.68383 -17.56208 -0.68601  1.000 27.44428 ? 391 HOH A O   1 
HETATM 2138 O  O   . HOH G 4 .   ? 20.06428 -29.49095 0.62963   1.000 37.80466 ? 392 HOH A O   1 
HETATM 2139 O  O   . HOH G 4 .   ? 40.38933 -26.35285 -8.87516  1.000 19.73841 ? 393 HOH A O   1 
HETATM 2140 O  O   . HOH G 4 .   ? 37.21756 -40.55889 -29.28552 1.000 33.42801 ? 394 HOH A O   1 
HETATM 2141 O  O   . HOH G 4 .   ? 46.22716 -24.54783 -14.75977 1.000 48.02048 ? 395 HOH A O   1 
HETATM 2142 O  O   . HOH G 4 .   ? 41.57603 -20.36668 -4.82442  1.000 23.04845 ? 396 HOH A O   1 
HETATM 2143 O  O   . HOH G 4 .   ? 26.10566 -10.61686 -23.05086 1.000 33.22524 ? 397 HOH A O   1 
HETATM 2144 O  O   . HOH G 4 .   ? 38.70327 -42.26191 -25.40413 1.000 38.92225 ? 398 HOH A O   1 
HETATM 2145 O  O   . HOH G 4 .   ? 39.83787 -26.55533 1.34318   1.000 37.32184 ? 399 HOH A O   1 
HETATM 2146 O  O   . HOH G 4 .   ? 13.37963 -20.90243 -2.84638  1.000 37.51027 ? 400 HOH A O   1 
HETATM 2147 O  O   . HOH G 4 .   ? 23.61095 -23.83701 -23.78553 1.000 21.65556 ? 401 HOH A O   1 
HETATM 2148 O  O   . HOH G 4 .   ? 35.46558 -16.15615 -27.88470 1.000 33.94502 ? 402 HOH A O   1 
HETATM 2149 O  O   . HOH G 4 .   ? 17.30696 -26.66319 -2.11837  1.000 39.17344 ? 403 HOH A O   1 
HETATM 2150 O  O   . HOH G 4 .   ? 37.86306 -38.35675 -30.82587 1.000 31.77625 ? 404 HOH A O   1 
HETATM 2151 O  O   . HOH G 4 .   ? 32.27056 -24.99656 4.86175   1.000 31.89191 ? 405 HOH A O   1 
HETATM 2152 O  O   . HOH G 4 .   ? 35.13678 -12.46657 -20.70095 1.000 41.51611 ? 406 HOH A O   1 
HETATM 2153 O  O   . HOH G 4 .   ? 34.12861 -21.30579 2.52762   1.000 25.26209 ? 407 HOH A O   1 
HETATM 2154 O  O   . HOH G 4 .   ? 30.31340 -11.00338 -8.30188  1.000 35.09436 ? 408 HOH A O   1 
HETATM 2155 O  O   . HOH G 4 .   ? 20.94440 -25.83971 -0.04574  1.000 31.11948 ? 409 HOH A O   1 
HETATM 2156 O  O   . HOH G 4 .   ? 19.95851 -24.49908 -9.91782  1.000 20.33355 ? 410 HOH A O   1 
HETATM 2157 O  O   . HOH G 4 .   ? 29.41721 -7.78087  -13.32150 1.000 43.57314 ? 411 HOH A O   1 
HETATM 2158 O  O   . HOH G 4 .   ? 39.82534 -30.42162 -5.24650  1.000 26.85199 ? 412 HOH A O   1 
HETATM 2159 O  O   . HOH G 4 .   ? 40.50056 -17.39117 -19.85282 1.000 34.74784 ? 413 HOH A O   1 
HETATM 2160 O  O   . HOH G 4 .   ? 29.071   -37.030   -30.996   1.000 33.07770 ? 414 HOH A O   1 
HETATM 2161 O  O   . HOH G 4 .   ? 28.95496 -9.91334  -16.66356 1.000 47.68612 ? 415 HOH A O   1 
HETATM 2162 O  O   . HOH G 4 .   ? 22.59600 -26.37412 1.67687   1.000 31.73297 ? 416 HOH A O   1 
HETATM 2163 O  O   . HOH G 4 .   ? 26.260   -23.941   4.841     1.000 46.78901 ? 417 HOH A O   1 
HETATM 2164 O  O   . HOH G 4 .   ? 29.69238 -16.65002 -31.12860 1.000 42.11377 ? 418 HOH A O   1 
HETATM 2165 O  O   . HOH G 4 .   ? 33.58513 -2.38928  -11.16814 1.000 35.40007 ? 419 HOH A O   1 
HETATM 2166 O  O   . HOH G 4 .   ? 21.68441 -10.81268 -17.71410 1.000 30.80240 ? 420 HOH A O   1 
HETATM 2167 O  O   . HOH G 4 .   ? 37.37902 -26.46661 4.17006   1.000 37.61396 ? 421 HOH A O   1 
HETATM 2168 O  O   . HOH G 4 .   ? 8.85815  -26.88085 -2.30401  1.000 38.57434 ? 422 HOH A O   1 
HETATM 2169 O  O   . HOH G 4 .   ? 24.21025 -38.89168 -12.58003 1.000 34.41659 ? 423 HOH A O   1 
HETATM 2170 O  O   . HOH G 4 .   ? 19.379   -18.961   -26.006   1.000 41.69806 ? 424 HOH A O   1 
HETATM 2171 O  O   . HOH G 4 .   ? 36.58516 -20.25622 -29.60936 1.000 40.58013 ? 425 HOH A O   1 
HETATM 2172 O  O   . HOH G 4 .   ? 31.74377 -9.95213  -17.72728 1.000 48.01598 ? 426 HOH A O   1 
HETATM 2173 O  O   . HOH G 4 .   ? 20.70796 -15.20157 -24.46215 1.000 38.96818 ? 427 HOH A O   1 
HETATM 2174 O  O   . HOH G 4 .   ? 9.21729  -28.80709 -3.08136  1.000 32.84816 ? 428 HOH A O   1 
HETATM 2175 O  O   . HOH G 4 .   ? 32.94494 -11.77599 -20.21787 1.000 41.46260 ? 429 HOH A O   1 
HETATM 2176 O  O   . HOH G 4 .   ? 17.79897 -12.97440 -6.35268  1.000 46.16143 ? 430 HOH A O   1 
HETATM 2177 O  O   . HOH G 4 .   ? 38.87508 -22.20494 -28.97094 1.000 33.86233 ? 431 HOH A O   1 
HETATM 2178 O  O   . HOH G 4 .   ? 24.64129 -10.19312 -17.60957 1.000 41.32376 ? 432 HOH A O   1 
HETATM 2179 O  O   . HOH G 4 .   ? 28.61864 -9.11262  -8.98192  1.000 52.72431 ? 433 HOH A O   1 
HETATM 2180 O  O   . HOH G 4 .   ? 29.722   -40.033   -30.309   1.000 29.61758 ? 434 HOH A O   1 
HETATM 2181 O  O   . HOH G 4 .   ? 31.82044 -26.36392 -28.47596 1.000 30.09946 ? 435 HOH A O   1 
HETATM 2182 O  O   . HOH G 4 .   ? 11.92506 -25.97500 -0.01273  1.000 42.55884 ? 436 HOH A O   1 
HETATM 2183 O  O   . HOH G 4 .   ? 41.554   -18.950   -0.714    1.000 28.43476 ? 437 HOH A O   1 
HETATM 2184 O  O   . HOH G 4 .   ? 24.94816 -11.74681 -10.82559 1.000 41.17360 ? 438 HOH A O   1 
HETATM 2185 O  O   . HOH G 4 .   ? 13.45810 -26.85494 2.30372   1.000 39.88262 ? 439 HOH A O   1 
HETATM 2186 O  O   . HOH G 4 .   ? 26.38685 -11.34565 -15.78978 1.000 41.58256 ? 440 HOH A O   1 
HETATM 2187 O  O   . HOH G 4 .   ? 20.35918 -11.74028 -11.49882 1.000 40.58551 ? 441 HOH A O   1 
HETATM 2188 O  O   . HOH G 4 .   ? 37.57265 -24.41927 -29.75145 1.000 28.83400 ? 442 HOH A O   1 
HETATM 2189 O  O   . HOH G 4 .   ? 26.47449 -11.19324 -8.91101  1.000 39.01179 ? 443 HOH A O   1 
HETATM 2190 O  O   . HOH G 4 .   ? 35.79068 -5.62362  -14.34855 1.000 45.18990 ? 444 HOH A O   1 
HETATM 2191 O  O   . HOH G 4 .   ? 24.75674 -42.87993 -13.60767 0.50  28.58433 ? 445 HOH A O   1 
HETATM 2192 O  O   . HOH G 4 .   ? 31.51081 -26.72459 6.90665   1.000 40.77147 ? 446 HOH A O   1 
HETATM 2193 O  O   . HOH G 4 .   ? 14.79300 -22.80671 -3.78411  1.000 33.39705 ? 447 HOH A O   1 
HETATM 2194 O  O   . HOH G 4 .   ? 1.945    -25.621   -4.761    1.000 49.50969 ? 448 HOH A O   1 
HETATM 2195 O  O   . HOH G 4 .   ? 42.73774 -22.80839 -8.20707  1.000 45.46262 ? 449 HOH A O   1 
HETATM 2196 O  O   . HOH G 4 .   ? 28.49800 -12.68610 -29.87885 1.000 38.24736 ? 450 HOH A O   1 
HETATM 2197 O  O   . HOH G 4 .   ? 39.52086 -14.19389 -5.83532  1.000 38.14607 ? 451 HOH A O   1 
HETATM 2198 O  O   . HOH G 4 .   ? 38.60618 -19.95179 -25.01738 1.000 35.48450 ? 452 HOH A O   1 
HETATM 2199 O  O   . HOH G 4 .   ? 17.17731 -23.44677 -4.32116  1.000 30.63022 ? 453 HOH A O   1 
HETATM 2200 O  O   . HOH G 4 .   ? 19.99447 -23.03824 1.71258   1.000 47.64229 ? 454 HOH A O   1 
HETATM 2201 O  O   . HOH G 4 .   ? 41.98102 -23.04849 -11.02337 1.000 38.16189 ? 455 HOH A O   1 
HETATM 2202 O  O   . HOH G 4 .   ? 27.62586 -9.24975  -24.55669 1.000 42.96562 ? 456 HOH A O   1 
HETATM 2203 O  O   . HOH G 4 .   ? 40.528   -4.842    -5.284    1.000 33.23765 ? 457 HOH A O   1 
HETATM 2204 O  O   . HOH G 4 .   ? 35.85539 -16.22149 -24.75489 1.000 44.53053 ? 458 HOH A O   1 
HETATM 2205 O  O   . HOH G 4 .   ? 34.98773 -23.63836 -30.64671 1.000 34.52458 ? 459 HOH A O   1 
HETATM 2206 O  O   . HOH G 4 .   ? 31.61948 -2.42131  -10.55885 1.000 37.83965 ? 460 HOH A O   1 
HETATM 2207 O  O   . HOH G 4 .   ? 24.03907 -9.19217  -11.50633 1.000 38.46114 ? 461 HOH A O   1 
HETATM 2208 O  O   . HOH G 4 .   ? 37.28229 -18.37904 -25.44275 1.000 40.91219 ? 462 HOH A O   1 
HETATM 2209 O  O   . HOH G 4 .   ? 17.11790 -36.39754 5.24159   1.000 37.88258 ? 463 HOH A O   1 
HETATM 2210 O  O   . HOH G 4 .   ? 41.48178 -18.87508 -22.07955 1.000 35.21636 ? 464 HOH A O   1 
HETATM 2211 O  O   . HOH G 4 .   ? 25.28076 -28.15456 2.91889   1.000 33.15435 ? 465 HOH A O   1 
HETATM 2212 O  O   . HOH G 4 .   ? 34.08201 -26.06274 -29.46633 1.000 35.73505 ? 466 HOH A O   1 
HETATM 2213 O  O   . HOH G 4 .   ? 44.86957 -32.19137 -1.15267  1.000 48.60089 ? 467 HOH A O   1 
HETATM 2214 O  O   . HOH G 4 .   ? 43.60809 -32.30015 -5.39358  1.000 32.48829 ? 468 HOH A O   1 
HETATM 2215 O  O   . HOH G 4 .   ? 17.82825 -24.16628 0.39136   1.000 39.47597 ? 469 HOH A O   1 
HETATM 2216 O  O   . HOH G 4 .   ? 25.17876 -20.81638 2.02144   1.000 46.48943 ? 470 HOH A O   1 
HETATM 2217 O  O   . HOH G 4 .   ? 25.99025 -28.90709 5.54825   1.000 37.06925 ? 471 HOH A O   1 
HETATM 2218 O  O   . HOH G 4 .   ? 19.05322 -34.34677 5.70699   1.000 34.99151 ? 472 HOH A O   1 
HETATM 2219 O  O   . HOH G 4 .   ? 15.04493 -24.91384 -2.17792  1.000 35.30598 ? 473 HOH A O   1 
HETATM 2220 O  O   . HOH G 4 .   ? 38.20048 -6.60967  -14.77339 1.000 43.94049 ? 474 HOH A O   1 
HETATM 2221 O  O   . HOH G 4 .   ? 22.10456 -11.99934 -7.87642  1.000 34.37301 ? 475 HOH A O   1 
HETATM 2222 O  O   . HOH G 4 .   ? 10.71464 -23.49217 0.30930   1.000 48.85817 ? 476 HOH A O   1 
HETATM 2223 O  O   . HOH G 4 .   ? 38.48280 -14.99727 -23.33977 1.000 46.87105 ? 477 HOH A O   1 
HETATM 2224 O  O   . HOH G 4 .   ? 35.19736 -23.23340 -33.23706 1.000 45.01219 ? 478 HOH A O   1 
HETATM 2225 O  O   . HOH H 4 .   ? 39.23718 -60.25124 -16.77061 1.000 45.35238 ? 301 HOH B O   1 
HETATM 2226 O  O   . HOH H 4 .   ? 45.20974 -41.86030 9.36613   1.000 40.07386 ? 302 HOH B O   1 
HETATM 2227 O  O   . HOH H 4 .   ? 37.16157 -46.34999 -22.72290 1.000 32.92807 ? 303 HOH B O   1 
HETATM 2228 O  O   . HOH H 4 .   ? 51.19487 -36.53385 -11.30212 1.000 37.64906 ? 304 HOH B O   1 
HETATM 2229 O  O   . HOH H 4 .   ? 51.27850 -50.79238 7.27598   1.000 40.27462 ? 305 HOH B O   1 
HETATM 2230 O  O   . HOH H 4 .   ? 41.23851 -60.71080 -5.05703  1.000 38.31156 ? 306 HOH B O   1 
HETATM 2231 O  O   . HOH H 4 .   ? 21.58480 -46.40014 5.33235   1.000 29.96791 ? 307 HOH B O   1 
HETATM 2232 O  O   . HOH H 4 .   ? 32.08800 -49.72950 11.42167  1.000 41.84636 ? 308 HOH B O   1 
HETATM 2233 O  O   . HOH H 4 .   ? 32.12546 -51.66036 -28.64461 1.000 33.39917 ? 309 HOH B O   1 
HETATM 2234 O  O   . HOH H 4 .   ? 36.09031 -56.78949 9.13842   1.000 35.46931 ? 310 HOH B O   1 
HETATM 2235 O  O   . HOH H 4 .   ? 33.39778 -54.96749 -30.98611 1.000 32.34871 ? 311 HOH B O   1 
HETATM 2236 O  O   . HOH H 4 .   ? 33.73226 -33.26380 3.29760   1.000 25.08456 ? 312 HOH B O   1 
HETATM 2237 O  O   . HOH H 4 .   ? 37.69236 -54.51032 -23.30942 1.000 31.95338 ? 313 HOH B O   1 
HETATM 2238 O  O   . HOH H 4 .   ? 43.10269 -28.21456 -7.27756  1.000 34.50508 ? 314 HOH B O   1 
HETATM 2239 O  O   . HOH H 4 .   ? 34.05043 -52.21143 -26.56814 1.000 29.22959 ? 315 HOH B O   1 
HETATM 2240 O  O   . HOH H 4 .   ? 54.49634 -43.03160 -4.05840  1.000 42.07840 ? 316 HOH B O   1 
HETATM 2241 O  O   . HOH H 4 .   ? 47.04343 -54.58329 -2.78086  1.000 40.19952 ? 317 HOH B O   1 
HETATM 2242 O  O   . HOH H 4 .   ? 37.95956 -42.59092 9.21705   1.000 39.33524 ? 318 HOH B O   1 
HETATM 2243 O  O   . HOH H 4 .   ? 30.21343 -59.08479 3.99751   1.000 38.88541 ? 319 HOH B O   1 
HETATM 2244 O  O   . HOH H 4 .   ? 35.03679 -46.61730 -19.96362 1.000 22.07084 ? 320 HOH B O   1 
HETATM 2245 O  O   . HOH H 4 .   ? 53.74629 -43.06532 1.73886   1.000 41.98756 ? 321 HOH B O   1 
HETATM 2246 O  O   . HOH H 4 .   ? 47.70881 -39.42802 8.08362   1.000 43.95735 ? 322 HOH B O   1 
HETATM 2247 O  O   . HOH H 4 .   ? 39.16866 -37.67777 8.42203   1.000 35.90668 ? 323 HOH B O   1 
HETATM 2248 O  O   . HOH H 4 .   ? 39.22974 -35.08506 -0.18973  1.000 24.98661 ? 324 HOH B O   1 
HETATM 2249 O  O   . HOH H 4 .   ? 52.91375 -48.20062 -7.16520  1.000 38.18107 ? 325 HOH B O   1 
HETATM 2250 O  O   . HOH H 4 .   ? 59.02665 -48.24359 -3.54157  1.000 37.34049 ? 326 HOH B O   1 
HETATM 2251 O  O   . HOH H 4 .   ? 30.68886 -47.69969 4.90184   1.000 27.01389 ? 327 HOH B O   1 
HETATM 2252 O  O   . HOH H 4 .   ? 25.92909 -35.78575 -5.77670  1.000 14.03030 ? 328 HOH B O   1 
HETATM 2253 O  O   . HOH H 4 .   ? 32.15887 -53.51364 9.63391   1.000 36.72345 ? 329 HOH B O   1 
HETATM 2254 O  O   . HOH H 4 .   ? 17.35311 -39.82373 -8.72766  1.000 23.28433 ? 330 HOH B O   1 
HETATM 2255 O  O   . HOH H 4 .   ? 47.02672 -47.45193 -15.28730 1.000 27.73559 ? 331 HOH B O   1 
HETATM 2256 O  O   . HOH H 4 .   ? 52.28584 -41.84962 -3.21819  1.000 31.37638 ? 332 HOH B O   1 
HETATM 2257 O  O   . HOH H 4 .   ? 36.54411 -48.69291 -21.16786 1.000 27.95542 ? 333 HOH B O   1 
HETATM 2258 O  O   . HOH H 4 .   ? 23.37426 -29.73712 2.15499   1.000 31.51842 ? 334 HOH B O   1 
HETATM 2259 O  O   . HOH H 4 .   ? 27.45187 -38.88983 -10.26447 1.000 22.29939 ? 335 HOH B O   1 
HETATM 2260 O  O   . HOH H 4 .   ? 44.00528 -41.90271 -18.09554 1.000 26.36869 ? 336 HOH B O   1 
HETATM 2261 O  O   . HOH H 4 .   ? 36.40744 -52.81616 -33.27780 1.000 43.22088 ? 337 HOH B O   1 
HETATM 2262 O  O   . HOH H 4 .   ? 48.70116 -56.07409 -11.67114 1.000 33.85196 ? 338 HOH B O   1 
HETATM 2263 O  O   . HOH H 4 .   ? 38.32930 -48.89722 -33.22403 1.000 43.93021 ? 339 HOH B O   1 
HETATM 2264 O  O   . HOH H 4 .   ? 47.23019 -33.87991 -19.15871 1.000 34.05075 ? 340 HOH B O   1 
HETATM 2265 O  O   . HOH H 4 .   ? 49.03695 -38.65038 -13.99211 1.000 29.73762 ? 341 HOH B O   1 
HETATM 2266 O  O   . HOH H 4 .   ? 50.81056 -49.84741 -10.83553 1.000 34.95345 ? 342 HOH B O   1 
HETATM 2267 O  O   . HOH H 4 .   ? 42.26720 -27.04253 -10.90809 1.000 31.51708 ? 343 HOH B O   1 
HETATM 2268 O  O   . HOH H 4 .   ? 32.91784 -42.96347 9.40087   1.000 34.74407 ? 344 HOH B O   1 
HETATM 2269 O  O   . HOH H 4 .   ? 41.06458 -50.30755 -19.16499 1.000 29.74352 ? 345 HOH B O   1 
HETATM 2270 O  O   . HOH H 4 .   ? 30.97978 -40.01685 7.64617   1.000 39.08463 ? 346 HOH B O   1 
HETATM 2271 O  O   . HOH H 4 .   ? 45.17519 -34.17862 -4.25340  1.000 30.22730 ? 347 HOH B O   1 
HETATM 2272 O  O   . HOH H 4 .   ? 31.96049 -52.84615 -19.29865 1.000 20.07526 ? 348 HOH B O   1 
HETATM 2273 O  O   . HOH H 4 .   ? 52.97347 -45.20330 -7.93907  1.000 36.08002 ? 349 HOH B O   1 
HETATM 2274 O  O   . HOH H 4 .   ? 32.06112 -60.75840 0.69005   1.000 42.46994 ? 350 HOH B O   1 
HETATM 2275 O  O   . HOH H 4 .   ? 38.16522 -56.08769 -19.28309 1.000 32.64936 ? 351 HOH B O   1 
HETATM 2276 O  O   . HOH H 4 .   ? 44.41202 -58.46688 -14.12563 1.000 34.41357 ? 352 HOH B O   1 
HETATM 2277 O  O   . HOH H 4 .   ? 40.64602 -28.13834 -12.84157 1.000 23.74644 ? 353 HOH B O   1 
HETATM 2278 O  O   . HOH H 4 .   ? 37.26846 -61.51182 -12.64731 1.000 34.38784 ? 354 HOH B O   1 
HETATM 2279 O  O   . HOH H 4 .   ? 32.02874 -55.99118 1.03764   1.000 30.01037 ? 355 HOH B O   1 
HETATM 2280 O  O   . HOH H 4 .   ? 33.36406 -50.83670 -35.40083 1.000 40.58948 ? 356 HOH B O   1 
HETATM 2281 O  O   . HOH H 4 .   ? 26.287   -45.263   9.873     1.000 39.02661 ? 357 HOH B O   1 
HETATM 2282 O  O   . HOH H 4 .   ? 32.22096 -48.86502 -28.69858 1.000 30.65934 ? 358 HOH B O   1 
HETATM 2283 O  O   . HOH H 4 .   ? 32.19081 -48.94471 -3.06622  1.000 26.43720 ? 359 HOH B O   1 
HETATM 2284 O  O   . HOH H 4 .   ? 42.53393 -37.00832 5.04132   1.000 29.78194 ? 360 HOH B O   1 
HETATM 2285 O  O   . HOH H 4 .   ? 37.86172 -49.15489 6.26945   1.000 32.49090 ? 361 HOH B O   1 
HETATM 2286 O  O   . HOH H 4 .   ? 25.84337 -42.71143 -11.02970 1.000 27.17819 ? 362 HOH B O   1 
HETATM 2287 O  O   . HOH H 4 .   ? 24.86519 -40.20500 -10.43157 1.000 25.97236 ? 363 HOH B O   1 
HETATM 2288 O  O   . HOH H 4 .   ? 50.98636 -50.12844 -6.85350  1.000 34.45307 ? 364 HOH B O   1 
HETATM 2289 O  O   . HOH H 4 .   ? 25.83679 -36.45682 -10.15504 1.000 16.66444 ? 365 HOH B O   1 
HETATM 2290 O  O   . HOH H 4 .   ? 39.73662 -45.40153 -22.43500 1.000 37.56600 ? 366 HOH B O   1 
HETATM 2291 O  O   . HOH H 4 .   ? 50.08408 -45.63196 -15.13045 1.000 36.25804 ? 367 HOH B O   1 
HETATM 2292 O  O   . HOH H 4 .   ? 46.38314 -44.67603 -16.16856 1.000 25.06366 ? 368 HOH B O   1 
HETATM 2293 O  O   . HOH H 4 .   ? 38.19851 -53.48106 -16.83790 1.000 30.03424 ? 369 HOH B O   1 
HETATM 2294 O  O   . HOH H 4 .   ? 48.70618 -32.66032 -14.52791 1.000 40.03986 ? 370 HOH B O   1 
HETATM 2295 O  O   . HOH H 4 .   ? 24.62247 -33.64187 -4.53234  1.000 13.66596 ? 371 HOH B O   1 
HETATM 2296 O  O   . HOH H 4 .   ? 42.81212 -35.05376 -2.65342  1.000 23.61120 ? 372 HOH B O   1 
HETATM 2297 O  O   . HOH H 4 .   ? 41.46000 -31.76806 -7.01100  1.000 25.02572 ? 373 HOH B O   1 
HETATM 2298 O  O   . HOH H 4 .   ? 27.16456 -36.55219 5.97029   1.000 26.12125 ? 374 HOH B O   1 
HETATM 2299 O  O   . HOH H 4 .   ? 46.61952 -56.39842 -7.24035  1.000 38.92028 ? 375 HOH B O   1 
HETATM 2300 O  O   . HOH H 4 .   ? 38.40833 -57.41361 -22.93265 1.000 37.90810 ? 376 HOH B O   1 
HETATM 2301 O  O   . HOH H 4 .   ? 30.93538 -53.88860 -0.24621  1.000 26.87685 ? 377 HOH B O   1 
HETATM 2302 O  O   . HOH H 4 .   ? 37.17196 -51.85201 -13.15321 1.000 23.89619 ? 378 HOH B O   1 
HETATM 2303 O  O   . HOH H 4 .   ? 50.09203 -36.22017 -2.95075  1.000 28.50250 ? 379 HOH B O   1 
HETATM 2304 O  O   . HOH H 4 .   ? 20.58055 -33.01021 3.62381   1.000 27.47303 ? 380 HOH B O   1 
HETATM 2305 O  O   . HOH H 4 .   ? 49.31288 -40.87879 6.10601   1.000 41.32360 ? 381 HOH B O   1 
HETATM 2306 O  O   . HOH H 4 .   ? 45.58151 -37.56685 1.97353   1.000 42.29067 ? 382 HOH B O   1 
HETATM 2307 O  O   . HOH H 4 .   ? 51.92360 -38.90537 -12.99332 1.000 31.25747 ? 383 HOH B O   1 
HETATM 2308 O  O   . HOH H 4 .   ? 41.80140 -56.47502 -21.00943 1.000 43.71436 ? 384 HOH B O   1 
HETATM 2309 O  O   . HOH H 4 .   ? 37.97191 -48.55550 8.85801   1.000 37.64807 ? 385 HOH B O   1 
HETATM 2310 O  O   . HOH H 4 .   ? 49.40773 -37.20349 -16.91276 1.000 32.34058 ? 386 HOH B O   1 
HETATM 2311 O  O   . HOH H 4 .   ? 47.37518 -53.74772 -18.47458 1.000 35.31642 ? 387 HOH B O   1 
HETATM 2312 O  O   . HOH H 4 .   ? 37.00438 -61.74006 -21.39649 1.000 44.22301 ? 388 HOH B O   1 
HETATM 2313 O  O   . HOH H 4 .   ? 53.40963 -34.50336 -8.71223  1.000 49.72457 ? 389 HOH B O   1 
HETATM 2314 O  O   . HOH H 4 .   ? 42.06577 -59.57079 4.90936   1.000 40.96251 ? 390 HOH B O   1 
HETATM 2315 O  O   . HOH H 4 .   ? 45.47383 -30.41007 -6.29686  1.000 37.30131 ? 391 HOH B O   1 
HETATM 2316 O  O   . HOH H 4 .   ? 50.22590 -44.57247 9.72296   1.000 44.84432 ? 392 HOH B O   1 
HETATM 2317 O  O   . HOH H 4 .   ? 34.36748 -55.23021 -26.01175 1.000 34.44142 ? 393 HOH B O   1 
HETATM 2318 O  O   . HOH H 4 .   ? 39.59525 -50.78826 -27.01846 1.000 42.29097 ? 394 HOH B O   1 
HETATM 2319 O  O   . HOH H 4 .   ? 52.28806 -52.27859 -7.95648  1.000 36.08779 ? 395 HOH B O   1 
HETATM 2320 O  O   . HOH H 4 .   ? 54.45007 -35.93277 -6.51730  1.000 50.19436 ? 396 HOH B O   1 
HETATM 2321 O  O   . HOH H 4 .   ? 55.94139 -49.28443 -8.15687  1.000 44.34344 ? 397 HOH B O   1 
HETATM 2322 O  O   . HOH H 4 .   ? 52.105   -49.749   8.397     1.000 43.32918 ? 398 HOH B O   1 
HETATM 2323 O  O   . HOH H 4 .   ? 29.269   -48.919   -35.155   1.000 41.45574 ? 399 HOH B O   1 
HETATM 2324 O  O   . HOH H 4 .   ? 38.92132 -50.04351 -21.16794 1.000 35.64289 ? 400 HOH B O   1 
HETATM 2325 O  O   . HOH H 4 .   ? 43.57051 -60.65444 -1.71128  1.000 37.84989 ? 401 HOH B O   1 
HETATM 2326 O  O   . HOH H 4 .   ? 46.32609 -54.75980 -5.08540  1.000 38.28766 ? 402 HOH B O   1 
HETATM 2327 O  O   . HOH H 4 .   ? 45.13332 -36.35289 7.98977   1.000 44.64941 ? 403 HOH B O   1 
HETATM 2328 O  O   . HOH H 4 .   ? 39.47268 -53.47857 -26.34067 1.000 46.55512 ? 404 HOH B O   1 
HETATM 2329 O  O   . HOH H 4 .   ? 49.88068 -34.82079 -15.41675 1.000 37.24405 ? 405 HOH B O   1 
HETATM 2330 O  O   . HOH H 4 .   ? 36.981   -61.355   -7.528    1.000 43.16123 ? 406 HOH B O   1 
HETATM 2331 O  O   . HOH H 4 .   ? 36.53739 -56.23523 -25.76475 1.000 47.89389 ? 407 HOH B O   1 
HETATM 2332 O  O   . HOH H 4 .   ? 22.84670 -32.18730 4.91994   1.000 34.02642 ? 408 HOH B O   1 
HETATM 2333 O  O   . HOH H 4 .   ? 25.07242 -36.78830 8.16276   1.000 39.46065 ? 409 HOH B O   1 
HETATM 2334 O  O   . HOH H 4 .   ? 50.82281 -53.32236 -13.57835 1.000 47.34632 ? 410 HOH B O   1 
HETATM 2335 O  O   . HOH H 4 .   ? 35.74124 -42.86845 -30.21844 1.000 44.55128 ? 411 HOH B O   1 
HETATM 2336 O  O   . HOH H 4 .   ? 28.43923 -41.40262 8.16777   1.000 41.11944 ? 412 HOH B O   1 
HETATM 2337 O  O   . HOH H 4 .   ? 28.81984 -47.43578 7.20641   1.000 33.47041 ? 413 HOH B O   1 
HETATM 2338 O  O   . HOH H 4 .   ? 22.42999 -38.84989 -13.60767 0.50  40.89493 ? 414 HOH B O   1 
HETATM 2339 O  O   . HOH H 4 .   ? 42.03251 -36.15788 7.82329   1.000 53.22679 ? 415 HOH B O   1 
HETATM 2340 O  O   . HOH H 4 .   ? 33.902   -62.950   -27.409   1.000 45.69809 ? 416 HOH B O   1 
HETATM 2341 O  O   . HOH H 4 .   ? 43.98991 -31.57677 -20.87900 1.000 32.94592 ? 417 HOH B O   1 
HETATM 2342 O  O   . HOH H 4 .   ? 49.30034 -52.11663 -15.75634 1.000 43.07854 ? 418 HOH B O   1 
HETATM 2343 O  O   . HOH H 4 .   ? 48.38471 -30.63952 -16.65101 1.000 49.16896 ? 419 HOH B O   1 
HETATM 2344 O  O   . HOH H 4 .   ? 16.73236 -40.96268 3.24896   1.000 33.24376 ? 420 HOH B O   1 
HETATM 2345 O  O   . HOH H 4 .   ? 45.90017 -29.25557 -16.76573 1.000 37.77615 ? 421 HOH B O   1 
HETATM 2346 O  O   . HOH H 4 .   ? 29.40964 -46.22683 9.08787   1.000 37.20602 ? 422 HOH B O   1 
HETATM 2347 O  O   . HOH H 4 .   ? 47.68748 -41.96255 10.85824  1.000 42.92465 ? 423 HOH B O   1 
HETATM 2348 O  O   . HOH H 4 .   ? 52.893   -43.641   6.386     1.000 43.10961 ? 424 HOH B O   1 
HETATM 2349 O  O   . HOH H 4 .   ? 49.03290 -49.81288 -14.30941 1.000 36.97506 ? 425 HOH B O   1 
HETATM 2350 O  O   . HOH H 4 .   ? 49.03070 -35.91919 -19.75732 1.000 42.57317 ? 426 HOH B O   1 
HETATM 2351 O  O   . HOH H 4 .   ? 40.04578 -49.41475 10.14853  1.000 39.34701 ? 427 HOH B O   1 
HETATM 2352 O  O   . HOH H 4 .   ? 40.27678 -52.99309 -18.30629 1.000 33.57610 ? 428 HOH B O   1 
HETATM 2353 O  O   . HOH H 4 .   ? 53.02605 -34.07614 -12.21730 1.000 48.50283 ? 429 HOH B O   1 
HETATM 2354 O  O   . HOH H 4 .   ? 42.49586 -50.22178 -21.66001 1.000 40.91328 ? 430 HOH B O   1 
HETATM 2355 O  O   . HOH H 4 .   ? 44.12627 -25.73064 -8.10218  1.000 45.47472 ? 431 HOH B O   1 
HETATM 2356 O  O   . HOH H 4 .   ? 30.67661 -47.00129 11.39256  1.000 40.79008 ? 432 HOH B O   1 
HETATM 2357 O  O   . HOH H 4 .   ? 38.13216 -46.47569 10.78885  1.000 47.77419 ? 433 HOH B O   1 
HETATM 2358 O  O   . HOH H 4 .   ? 37.81704 -35.65419 9.27519   1.000 42.93688 ? 434 HOH B O   1 
HETATM 2359 O  O   . HOH H 4 .   ? 48.62556 -56.33301 -9.44165  1.000 39.41234 ? 435 HOH B O   1 
HETATM 2360 O  O   . HOH H 4 .   ? 40.11882 -54.58083 -20.20176 1.000 34.16006 ? 436 HOH B O   1 
HETATM 2361 O  O   . HOH H 4 .   ? 41.08662 -28.14129 -5.30426  1.000 26.01788 ? 437 HOH B O   1 
HETATM 2362 O  O   . HOH H 4 .   ? 43.54843 -41.16662 -20.61401 1.000 32.28781 ? 438 HOH B O   1 
HETATM 2363 O  O   . HOH H 4 .   ? 39.59903 -52.81792 -22.05685 1.000 39.29092 ? 439 HOH B O   1 
HETATM 2364 O  O   . HOH H 4 .   ? 47.05173 -32.57855 -2.57797  1.000 47.20733 ? 440 HOH B O   1 
HETATM 2365 O  O   . HOH H 4 .   ? 39.18573 -41.19970 -28.13269 1.000 39.16348 ? 441 HOH B O   1 
HETATM 2366 O  O   . HOH H 4 .   ? 38.742   -45.243   -34.125   1.000 41.92195 ? 442 HOH B O   1 
HETATM 2367 O  O   . HOH H 4 .   ? 39.00092 -48.81532 -35.66039 1.000 47.14343 ? 443 HOH B O   1 
HETATM 2368 O  O   . HOH H 4 .   ? 53.47421 -48.75719 -10.19443 1.000 41.87221 ? 444 HOH B O   1 
HETATM 2369 O  O   . HOH H 4 .   ? 25.47526 -33.44085 6.09319   1.000 37.15586 ? 445 HOH B O   1 
# 
