data_8X6E
# 
_entry.id   8X6E 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8X6E         pdb_00008x6e 10.2210/pdb8x6e/pdb 
WWPDB D_1300042470 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8X6E 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              lwniu@ustc.edu.cn 
_pdbx_contact_author.name_first         Liwen 
_pdbx_contact_author.name_last          Niu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1217-1782 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Gao, Y.'   1 ? 
'Niu, L.W.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structural study of yeast TBF1 protein' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gao, Y.'   1 ? 
primary 'Niu, L.W.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Protein TBF1' 35418.562 1   ? ? ? ? 
2 water   nat water          18.015    114 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDSQVPNNNESLNRFNDIIQSLPARTRLTICSLCLLDNISTQLLRFLILNANSPNIIAVLTDQTAFLSSGETEIFQTLVK
LFKQIRMIYHTRSPLLSVHDVAPGLWFPNSPPPLILRGHEAFIITAIRKANLLTFLLTSLNCLNYGFELLQSIFLDIFCP
NTNTVGNNSLEQSGKFLKSQAILYLDLKTQAYIAGLKEFQDETNEISLEKKQELLDLIFPSNLADILVQRRTGDSGDITL
LTPSEKDFVERCDRRRENLKIVQDFNSLTQSYEWAQFIRELLDYCNKNMGLIIWGRKGRGKSPLYDFDVN
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDSQVPNNNESLNRFNDIIQSLPARTRLTICSLCLLDNISTQLLRFLILNANSPNIIAVLTDQTAFLSSGETEIFQTLVK
LFKQIRMIYHTRSPLLSVHDVAPGLWFPNSPPPLILRGHEAFIITAIRKANLLTFLLTSLNCLNYGFELLQSIFLDIFCP
NTNTVGNNSLEQSGKFLKSQAILYLDLKTQAYIAGLKEFQDETNEISLEKKQELLDLIFPSNLADILVQRRTGDSGDITL
LTPSEKDFVERCDRRRENLKIVQDFNSLTQSYEWAQFIRELLDYCNKNMGLIIWGRKGRGKSPLYDFDVN
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   SER n 
1 4   GLN n 
1 5   VAL n 
1 6   PRO n 
1 7   ASN n 
1 8   ASN n 
1 9   ASN n 
1 10  GLU n 
1 11  SER n 
1 12  LEU n 
1 13  ASN n 
1 14  ARG n 
1 15  PHE n 
1 16  ASN n 
1 17  ASP n 
1 18  ILE n 
1 19  ILE n 
1 20  GLN n 
1 21  SER n 
1 22  LEU n 
1 23  PRO n 
1 24  ALA n 
1 25  ARG n 
1 26  THR n 
1 27  ARG n 
1 28  LEU n 
1 29  THR n 
1 30  ILE n 
1 31  CYS n 
1 32  SER n 
1 33  LEU n 
1 34  CYS n 
1 35  LEU n 
1 36  LEU n 
1 37  ASP n 
1 38  ASN n 
1 39  ILE n 
1 40  SER n 
1 41  THR n 
1 42  GLN n 
1 43  LEU n 
1 44  LEU n 
1 45  ARG n 
1 46  PHE n 
1 47  LEU n 
1 48  ILE n 
1 49  LEU n 
1 50  ASN n 
1 51  ALA n 
1 52  ASN n 
1 53  SER n 
1 54  PRO n 
1 55  ASN n 
1 56  ILE n 
1 57  ILE n 
1 58  ALA n 
1 59  VAL n 
1 60  LEU n 
1 61  THR n 
1 62  ASP n 
1 63  GLN n 
1 64  THR n 
1 65  ALA n 
1 66  PHE n 
1 67  LEU n 
1 68  SER n 
1 69  SER n 
1 70  GLY n 
1 71  GLU n 
1 72  THR n 
1 73  GLU n 
1 74  ILE n 
1 75  PHE n 
1 76  GLN n 
1 77  THR n 
1 78  LEU n 
1 79  VAL n 
1 80  LYS n 
1 81  LEU n 
1 82  PHE n 
1 83  LYS n 
1 84  GLN n 
1 85  ILE n 
1 86  ARG n 
1 87  MET n 
1 88  ILE n 
1 89  TYR n 
1 90  HIS n 
1 91  THR n 
1 92  ARG n 
1 93  SER n 
1 94  PRO n 
1 95  LEU n 
1 96  LEU n 
1 97  SER n 
1 98  VAL n 
1 99  HIS n 
1 100 ASP n 
1 101 VAL n 
1 102 ALA n 
1 103 PRO n 
1 104 GLY n 
1 105 LEU n 
1 106 TRP n 
1 107 PHE n 
1 108 PRO n 
1 109 ASN n 
1 110 SER n 
1 111 PRO n 
1 112 PRO n 
1 113 PRO n 
1 114 LEU n 
1 115 ILE n 
1 116 LEU n 
1 117 ARG n 
1 118 GLY n 
1 119 HIS n 
1 120 GLU n 
1 121 ALA n 
1 122 PHE n 
1 123 ILE n 
1 124 ILE n 
1 125 THR n 
1 126 ALA n 
1 127 ILE n 
1 128 ARG n 
1 129 LYS n 
1 130 ALA n 
1 131 ASN n 
1 132 LEU n 
1 133 LEU n 
1 134 THR n 
1 135 PHE n 
1 136 LEU n 
1 137 LEU n 
1 138 THR n 
1 139 SER n 
1 140 LEU n 
1 141 ASN n 
1 142 CYS n 
1 143 LEU n 
1 144 ASN n 
1 145 TYR n 
1 146 GLY n 
1 147 PHE n 
1 148 GLU n 
1 149 LEU n 
1 150 LEU n 
1 151 GLN n 
1 152 SER n 
1 153 ILE n 
1 154 PHE n 
1 155 LEU n 
1 156 ASP n 
1 157 ILE n 
1 158 PHE n 
1 159 CYS n 
1 160 PRO n 
1 161 ASN n 
1 162 THR n 
1 163 ASN n 
1 164 THR n 
1 165 VAL n 
1 166 GLY n 
1 167 ASN n 
1 168 ASN n 
1 169 SER n 
1 170 LEU n 
1 171 GLU n 
1 172 GLN n 
1 173 SER n 
1 174 GLY n 
1 175 LYS n 
1 176 PHE n 
1 177 LEU n 
1 178 LYS n 
1 179 SER n 
1 180 GLN n 
1 181 ALA n 
1 182 ILE n 
1 183 LEU n 
1 184 TYR n 
1 185 LEU n 
1 186 ASP n 
1 187 LEU n 
1 188 LYS n 
1 189 THR n 
1 190 GLN n 
1 191 ALA n 
1 192 TYR n 
1 193 ILE n 
1 194 ALA n 
1 195 GLY n 
1 196 LEU n 
1 197 LYS n 
1 198 GLU n 
1 199 PHE n 
1 200 GLN n 
1 201 ASP n 
1 202 GLU n 
1 203 THR n 
1 204 ASN n 
1 205 GLU n 
1 206 ILE n 
1 207 SER n 
1 208 LEU n 
1 209 GLU n 
1 210 LYS n 
1 211 LYS n 
1 212 GLN n 
1 213 GLU n 
1 214 LEU n 
1 215 LEU n 
1 216 ASP n 
1 217 LEU n 
1 218 ILE n 
1 219 PHE n 
1 220 PRO n 
1 221 SER n 
1 222 ASN n 
1 223 LEU n 
1 224 ALA n 
1 225 ASP n 
1 226 ILE n 
1 227 LEU n 
1 228 VAL n 
1 229 GLN n 
1 230 ARG n 
1 231 ARG n 
1 232 THR n 
1 233 GLY n 
1 234 ASP n 
1 235 SER n 
1 236 GLY n 
1 237 ASP n 
1 238 ILE n 
1 239 THR n 
1 240 LEU n 
1 241 LEU n 
1 242 THR n 
1 243 PRO n 
1 244 SER n 
1 245 GLU n 
1 246 LYS n 
1 247 ASP n 
1 248 PHE n 
1 249 VAL n 
1 250 GLU n 
1 251 ARG n 
1 252 CYS n 
1 253 ASP n 
1 254 ARG n 
1 255 ARG n 
1 256 ARG n 
1 257 GLU n 
1 258 ASN n 
1 259 LEU n 
1 260 LYS n 
1 261 ILE n 
1 262 VAL n 
1 263 GLN n 
1 264 ASP n 
1 265 PHE n 
1 266 ASN n 
1 267 SER n 
1 268 LEU n 
1 269 THR n 
1 270 GLN n 
1 271 SER n 
1 272 TYR n 
1 273 GLU n 
1 274 TRP n 
1 275 ALA n 
1 276 GLN n 
1 277 PHE n 
1 278 ILE n 
1 279 ARG n 
1 280 GLU n 
1 281 LEU n 
1 282 LEU n 
1 283 ASP n 
1 284 TYR n 
1 285 CYS n 
1 286 ASN n 
1 287 LYS n 
1 288 ASN n 
1 289 MET n 
1 290 GLY n 
1 291 LEU n 
1 292 ILE n 
1 293 ILE n 
1 294 TRP n 
1 295 GLY n 
1 296 ARG n 
1 297 LYS n 
1 298 GLY n 
1 299 ARG n 
1 300 GLY n 
1 301 LYS n 
1 302 SER n 
1 303 PRO n 
1 304 LEU n 
1 305 TYR n 
1 306 ASP n 
1 307 PHE n 
1 308 ASP n 
1 309 VAL n 
1 310 ASN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   310 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 TBF1 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Saccharomyces cerevisiae S288C' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     559292 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASP 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   ?   ?   ?   A . n 
A 1 4   GLN 4   4   ?   ?   ?   A . n 
A 1 5   VAL 5   5   ?   ?   ?   A . n 
A 1 6   PRO 6   6   ?   ?   ?   A . n 
A 1 7   ASN 7   7   7   ASN ASN A . n 
A 1 8   ASN 8   8   8   ASN ASN A . n 
A 1 9   ASN 9   9   9   ASN ASN A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  SER 11  11  11  SER SER A . n 
A 1 12  LEU 12  12  12  LEU LEU A . n 
A 1 13  ASN 13  13  13  ASN ASN A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  PHE 15  15  15  PHE PHE A . n 
A 1 16  ASN 16  16  16  ASN ASN A . n 
A 1 17  ASP 17  17  17  ASP ASP A . n 
A 1 18  ILE 18  18  18  ILE ILE A . n 
A 1 19  ILE 19  19  19  ILE ILE A . n 
A 1 20  GLN 20  20  20  GLN GLN A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  LEU 22  22  22  LEU LEU A . n 
A 1 23  PRO 23  23  23  PRO PRO A . n 
A 1 24  ALA 24  24  24  ALA ALA A . n 
A 1 25  ARG 25  25  25  ARG ARG A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  ILE 30  30  30  ILE ILE A . n 
A 1 31  CYS 31  31  31  CYS CYS A . n 
A 1 32  SER 32  32  32  SER SER A . n 
A 1 33  LEU 33  33  33  LEU LEU A . n 
A 1 34  CYS 34  34  34  CYS CYS A . n 
A 1 35  LEU 35  35  35  LEU LEU A . n 
A 1 36  LEU 36  36  36  LEU LEU A . n 
A 1 37  ASP 37  37  37  ASP ASP A . n 
A 1 38  ASN 38  38  38  ASN ASN A . n 
A 1 39  ILE 39  39  39  ILE ILE A . n 
A 1 40  SER 40  40  40  SER SER A . n 
A 1 41  THR 41  41  41  THR THR A . n 
A 1 42  GLN 42  42  42  GLN GLN A . n 
A 1 43  LEU 43  43  43  LEU LEU A . n 
A 1 44  LEU 44  44  44  LEU LEU A . n 
A 1 45  ARG 45  45  45  ARG ARG A . n 
A 1 46  PHE 46  46  46  PHE PHE A . n 
A 1 47  LEU 47  47  47  LEU LEU A . n 
A 1 48  ILE 48  48  48  ILE ILE A . n 
A 1 49  LEU 49  49  49  LEU LEU A . n 
A 1 50  ASN 50  50  50  ASN ASN A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  ASN 52  52  52  ASN ASN A . n 
A 1 53  SER 53  53  53  SER SER A . n 
A 1 54  PRO 54  54  54  PRO PRO A . n 
A 1 55  ASN 55  55  55  ASN ASN A . n 
A 1 56  ILE 56  56  56  ILE ILE A . n 
A 1 57  ILE 57  57  57  ILE ILE A . n 
A 1 58  ALA 58  58  58  ALA ALA A . n 
A 1 59  VAL 59  59  59  VAL VAL A . n 
A 1 60  LEU 60  60  60  LEU LEU A . n 
A 1 61  THR 61  61  61  THR THR A . n 
A 1 62  ASP 62  62  62  ASP ASP A . n 
A 1 63  GLN 63  63  63  GLN GLN A . n 
A 1 64  THR 64  64  ?   ?   ?   A . n 
A 1 65  ALA 65  65  ?   ?   ?   A . n 
A 1 66  PHE 66  66  ?   ?   ?   A . n 
A 1 67  LEU 67  67  ?   ?   ?   A . n 
A 1 68  SER 68  68  ?   ?   ?   A . n 
A 1 69  SER 69  69  69  SER SER A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  GLU 71  71  71  GLU GLU A . n 
A 1 72  THR 72  72  72  THR THR A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  ILE 74  74  74  ILE ILE A . n 
A 1 75  PHE 75  75  75  PHE PHE A . n 
A 1 76  GLN 76  76  76  GLN GLN A . n 
A 1 77  THR 77  77  77  THR THR A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  LYS 80  80  80  LYS LYS A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  PHE 82  82  82  PHE PHE A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  GLN 84  84  84  GLN GLN A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  ARG 86  86  86  ARG ARG A . n 
A 1 87  MET 87  87  87  MET MET A . n 
A 1 88  ILE 88  88  88  ILE ILE A . n 
A 1 89  TYR 89  89  89  TYR TYR A . n 
A 1 90  HIS 90  90  90  HIS HIS A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  ARG 92  92  92  ARG ARG A . n 
A 1 93  SER 93  93  93  SER SER A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  SER 97  97  97  SER SER A . n 
A 1 98  VAL 98  98  98  VAL VAL A . n 
A 1 99  HIS 99  99  99  HIS HIS A . n 
A 1 100 ASP 100 100 100 ASP ASP A . n 
A 1 101 VAL 101 101 101 VAL VAL A . n 
A 1 102 ALA 102 102 102 ALA ALA A . n 
A 1 103 PRO 103 103 103 PRO PRO A . n 
A 1 104 GLY 104 104 104 GLY GLY A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 TRP 106 106 106 TRP TRP A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 ASN 109 109 109 ASN ASN A . n 
A 1 110 SER 110 110 110 SER SER A . n 
A 1 111 PRO 111 111 111 PRO PRO A . n 
A 1 112 PRO 112 112 112 PRO PRO A . n 
A 1 113 PRO 113 113 113 PRO PRO A . n 
A 1 114 LEU 114 114 114 LEU LEU A . n 
A 1 115 ILE 115 115 115 ILE ILE A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 ARG 117 117 117 ARG ARG A . n 
A 1 118 GLY 118 118 118 GLY GLY A . n 
A 1 119 HIS 119 119 119 HIS HIS A . n 
A 1 120 GLU 120 120 120 GLU GLU A . n 
A 1 121 ALA 121 121 121 ALA ALA A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 ILE 123 123 123 ILE ILE A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 THR 125 125 125 THR THR A . n 
A 1 126 ALA 126 126 126 ALA ALA A . n 
A 1 127 ILE 127 127 127 ILE ILE A . n 
A 1 128 ARG 128 128 128 ARG ARG A . n 
A 1 129 LYS 129 129 129 LYS LYS A . n 
A 1 130 ALA 130 130 130 ALA ALA A . n 
A 1 131 ASN 131 131 131 ASN ASN A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 PHE 135 135 135 PHE PHE A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 LEU 137 137 137 LEU LEU A . n 
A 1 138 THR 138 138 138 THR THR A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 ASN 141 141 141 ASN ASN A . n 
A 1 142 CYS 142 142 142 CYS CYS A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 ASN 144 144 144 ASN ASN A . n 
A 1 145 TYR 145 145 145 TYR TYR A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 PHE 147 147 147 PHE PHE A . n 
A 1 148 GLU 148 148 148 GLU GLU A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 LEU 150 150 150 LEU LEU A . n 
A 1 151 GLN 151 151 151 GLN GLN A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 ILE 153 153 153 ILE ILE A . n 
A 1 154 PHE 154 154 154 PHE PHE A . n 
A 1 155 LEU 155 155 155 LEU LEU A . n 
A 1 156 ASP 156 156 156 ASP ASP A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 PHE 158 158 158 PHE PHE A . n 
A 1 159 CYS 159 159 159 CYS CYS A . n 
A 1 160 PRO 160 160 160 PRO PRO A . n 
A 1 161 ASN 161 161 161 ASN ASN A . n 
A 1 162 THR 162 162 162 THR THR A . n 
A 1 163 ASN 163 163 ?   ?   ?   A . n 
A 1 164 THR 164 164 ?   ?   ?   A . n 
A 1 165 VAL 165 165 ?   ?   ?   A . n 
A 1 166 GLY 166 166 ?   ?   ?   A . n 
A 1 167 ASN 167 167 ?   ?   ?   A . n 
A 1 168 ASN 168 168 ?   ?   ?   A . n 
A 1 169 SER 169 169 ?   ?   ?   A . n 
A 1 170 LEU 170 170 ?   ?   ?   A . n 
A 1 171 GLU 171 171 ?   ?   ?   A . n 
A 1 172 GLN 172 172 172 GLN GLN A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 LYS 175 175 175 LYS LYS A . n 
A 1 176 PHE 176 176 176 PHE PHE A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 LYS 178 178 178 LYS LYS A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 GLN 180 180 180 GLN GLN A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 ILE 182 182 182 ILE ILE A . n 
A 1 183 LEU 183 183 183 LEU LEU A . n 
A 1 184 TYR 184 184 184 TYR TYR A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 ASP 186 186 186 ASP ASP A . n 
A 1 187 LEU 187 187 187 LEU LEU A . n 
A 1 188 LYS 188 188 188 LYS LYS A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 GLN 190 190 190 GLN GLN A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 TYR 192 192 192 TYR TYR A . n 
A 1 193 ILE 193 193 193 ILE ILE A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 LEU 196 196 196 LEU LEU A . n 
A 1 197 LYS 197 197 197 LYS LYS A . n 
A 1 198 GLU 198 198 198 GLU GLU A . n 
A 1 199 PHE 199 199 199 PHE PHE A . n 
A 1 200 GLN 200 200 200 GLN GLN A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 GLU 202 202 202 GLU GLU A . n 
A 1 203 THR 203 203 203 THR THR A . n 
A 1 204 ASN 204 204 204 ASN ASN A . n 
A 1 205 GLU 205 205 205 GLU GLU A . n 
A 1 206 ILE 206 206 206 ILE ILE A . n 
A 1 207 SER 207 207 207 SER SER A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 GLU 209 209 209 GLU GLU A . n 
A 1 210 LYS 210 210 210 LYS LYS A . n 
A 1 211 LYS 211 211 211 LYS LYS A . n 
A 1 212 GLN 212 212 212 GLN GLN A . n 
A 1 213 GLU 213 213 213 GLU GLU A . n 
A 1 214 LEU 214 214 214 LEU LEU A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 ILE 218 218 218 ILE ILE A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 PRO 220 220 220 PRO PRO A . n 
A 1 221 SER 221 221 221 SER SER A . n 
A 1 222 ASN 222 222 222 ASN ASN A . n 
A 1 223 LEU 223 223 223 LEU LEU A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 ASP 225 225 225 ASP ASP A . n 
A 1 226 ILE 226 226 226 ILE ILE A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 GLN 229 229 229 GLN GLN A . n 
A 1 230 ARG 230 230 230 ARG ARG A . n 
A 1 231 ARG 231 231 231 ARG ARG A . n 
A 1 232 THR 232 232 232 THR THR A . n 
A 1 233 GLY 233 233 233 GLY GLY A . n 
A 1 234 ASP 234 234 234 ASP ASP A . n 
A 1 235 SER 235 235 235 SER SER A . n 
A 1 236 GLY 236 236 236 GLY GLY A . n 
A 1 237 ASP 237 237 237 ASP ASP A . n 
A 1 238 ILE 238 238 238 ILE ILE A . n 
A 1 239 THR 239 239 239 THR THR A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 THR 242 242 242 THR THR A . n 
A 1 243 PRO 243 243 243 PRO PRO A . n 
A 1 244 SER 244 244 244 SER SER A . n 
A 1 245 GLU 245 245 245 GLU GLU A . n 
A 1 246 LYS 246 246 246 LYS LYS A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 PHE 248 248 248 PHE PHE A . n 
A 1 249 VAL 249 249 249 VAL VAL A . n 
A 1 250 GLU 250 250 250 GLU GLU A . n 
A 1 251 ARG 251 251 251 ARG ARG A . n 
A 1 252 CYS 252 252 252 CYS CYS A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 ARG 254 254 254 ARG ARG A . n 
A 1 255 ARG 255 255 255 ARG ARG A . n 
A 1 256 ARG 256 256 256 ARG ARG A . n 
A 1 257 GLU 257 257 257 GLU GLU A . n 
A 1 258 ASN 258 258 258 ASN ASN A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 LYS 260 260 260 LYS LYS A . n 
A 1 261 ILE 261 261 261 ILE ILE A . n 
A 1 262 VAL 262 262 262 VAL VAL A . n 
A 1 263 GLN 263 263 263 GLN GLN A . n 
A 1 264 ASP 264 264 264 ASP ASP A . n 
A 1 265 PHE 265 265 265 PHE PHE A . n 
A 1 266 ASN 266 266 266 ASN ASN A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 THR 269 269 269 THR THR A . n 
A 1 270 GLN 270 270 270 GLN GLN A . n 
A 1 271 SER 271 271 271 SER SER A . n 
A 1 272 TYR 272 272 272 TYR TYR A . n 
A 1 273 GLU 273 273 273 GLU GLU A . n 
A 1 274 TRP 274 274 274 TRP TRP A . n 
A 1 275 ALA 275 275 275 ALA ALA A . n 
A 1 276 GLN 276 276 276 GLN GLN A . n 
A 1 277 PHE 277 277 277 PHE PHE A . n 
A 1 278 ILE 278 278 278 ILE ILE A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 LEU 281 281 281 LEU LEU A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 ASP 283 283 283 ASP ASP A . n 
A 1 284 TYR 284 284 284 TYR TYR A . n 
A 1 285 CYS 285 285 285 CYS CYS A . n 
A 1 286 ASN 286 286 286 ASN ASN A . n 
A 1 287 LYS 287 287 287 LYS LYS A . n 
A 1 288 ASN 288 288 288 ASN ASN A . n 
A 1 289 MET 289 289 289 MET MET A . n 
A 1 290 GLY 290 290 290 GLY GLY A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 ILE 292 292 292 ILE ILE A . n 
A 1 293 ILE 293 293 293 ILE ILE A . n 
A 1 294 TRP 294 294 294 TRP TRP A . n 
A 1 295 GLY 295 295 295 GLY GLY A . n 
A 1 296 ARG 296 296 296 ARG ARG A . n 
A 1 297 LYS 297 297 297 LYS LYS A . n 
A 1 298 GLY 298 298 298 GLY GLY A . n 
A 1 299 ARG 299 299 299 ARG ARG A . n 
A 1 300 GLY 300 300 300 GLY GLY A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 SER 302 302 302 SER SER A . n 
A 1 303 PRO 303 303 303 PRO PRO A . n 
A 1 304 LEU 304 304 304 LEU LEU A . n 
A 1 305 TYR 305 305 305 TYR TYR A . n 
A 1 306 ASP 306 306 306 ASP ASP A . n 
A 1 307 PHE 307 307 307 PHE PHE A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 VAL 309 309 309 VAL VAL A . n 
A 1 310 ASN 310 310 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   401 98  HOH HOH A . 
B 2 HOH 2   402 76  HOH HOH A . 
B 2 HOH 3   403 72  HOH HOH A . 
B 2 HOH 4   404 81  HOH HOH A . 
B 2 HOH 5   405 57  HOH HOH A . 
B 2 HOH 6   406 29  HOH HOH A . 
B 2 HOH 7   407 75  HOH HOH A . 
B 2 HOH 8   408 22  HOH HOH A . 
B 2 HOH 9   409 54  HOH HOH A . 
B 2 HOH 10  410 19  HOH HOH A . 
B 2 HOH 11  411 89  HOH HOH A . 
B 2 HOH 12  412 23  HOH HOH A . 
B 2 HOH 13  413 36  HOH HOH A . 
B 2 HOH 14  414 18  HOH HOH A . 
B 2 HOH 15  415 85  HOH HOH A . 
B 2 HOH 16  416 50  HOH HOH A . 
B 2 HOH 17  417 35  HOH HOH A . 
B 2 HOH 18  418 41  HOH HOH A . 
B 2 HOH 19  419 25  HOH HOH A . 
B 2 HOH 20  420 14  HOH HOH A . 
B 2 HOH 21  421 93  HOH HOH A . 
B 2 HOH 22  422 16  HOH HOH A . 
B 2 HOH 23  423 106 HOH HOH A . 
B 2 HOH 24  424 3   HOH HOH A . 
B 2 HOH 25  425 47  HOH HOH A . 
B 2 HOH 26  426 46  HOH HOH A . 
B 2 HOH 27  427 105 HOH HOH A . 
B 2 HOH 28  428 5   HOH HOH A . 
B 2 HOH 29  429 1   HOH HOH A . 
B 2 HOH 30  430 39  HOH HOH A . 
B 2 HOH 31  431 73  HOH HOH A . 
B 2 HOH 32  432 61  HOH HOH A . 
B 2 HOH 33  433 17  HOH HOH A . 
B 2 HOH 34  434 9   HOH HOH A . 
B 2 HOH 35  435 101 HOH HOH A . 
B 2 HOH 36  436 68  HOH HOH A . 
B 2 HOH 37  437 6   HOH HOH A . 
B 2 HOH 38  438 91  HOH HOH A . 
B 2 HOH 39  439 27  HOH HOH A . 
B 2 HOH 40  440 87  HOH HOH A . 
B 2 HOH 41  441 79  HOH HOH A . 
B 2 HOH 42  442 52  HOH HOH A . 
B 2 HOH 43  443 77  HOH HOH A . 
B 2 HOH 44  444 51  HOH HOH A . 
B 2 HOH 45  445 11  HOH HOH A . 
B 2 HOH 46  446 30  HOH HOH A . 
B 2 HOH 47  447 28  HOH HOH A . 
B 2 HOH 48  448 31  HOH HOH A . 
B 2 HOH 49  449 96  HOH HOH A . 
B 2 HOH 50  450 7   HOH HOH A . 
B 2 HOH 51  451 56  HOH HOH A . 
B 2 HOH 52  452 64  HOH HOH A . 
B 2 HOH 53  453 43  HOH HOH A . 
B 2 HOH 54  454 55  HOH HOH A . 
B 2 HOH 55  455 15  HOH HOH A . 
B 2 HOH 56  456 21  HOH HOH A . 
B 2 HOH 57  457 12  HOH HOH A . 
B 2 HOH 58  458 20  HOH HOH A . 
B 2 HOH 59  459 8   HOH HOH A . 
B 2 HOH 60  460 48  HOH HOH A . 
B 2 HOH 61  461 97  HOH HOH A . 
B 2 HOH 62  462 86  HOH HOH A . 
B 2 HOH 63  463 33  HOH HOH A . 
B 2 HOH 64  464 80  HOH HOH A . 
B 2 HOH 65  465 40  HOH HOH A . 
B 2 HOH 66  466 2   HOH HOH A . 
B 2 HOH 67  467 104 HOH HOH A . 
B 2 HOH 68  468 10  HOH HOH A . 
B 2 HOH 69  469 24  HOH HOH A . 
B 2 HOH 70  470 34  HOH HOH A . 
B 2 HOH 71  471 60  HOH HOH A . 
B 2 HOH 72  472 74  HOH HOH A . 
B 2 HOH 73  473 63  HOH HOH A . 
B 2 HOH 74  474 102 HOH HOH A . 
B 2 HOH 75  475 65  HOH HOH A . 
B 2 HOH 76  476 107 HOH HOH A . 
B 2 HOH 77  477 26  HOH HOH A . 
B 2 HOH 78  478 67  HOH HOH A . 
B 2 HOH 79  479 71  HOH HOH A . 
B 2 HOH 80  480 4   HOH HOH A . 
B 2 HOH 81  481 38  HOH HOH A . 
B 2 HOH 82  482 44  HOH HOH A . 
B 2 HOH 83  483 53  HOH HOH A . 
B 2 HOH 84  484 84  HOH HOH A . 
B 2 HOH 85  485 103 HOH HOH A . 
B 2 HOH 86  486 88  HOH HOH A . 
B 2 HOH 87  487 59  HOH HOH A . 
B 2 HOH 88  488 42  HOH HOH A . 
B 2 HOH 89  489 37  HOH HOH A . 
B 2 HOH 90  490 100 HOH HOH A . 
B 2 HOH 91  491 62  HOH HOH A . 
B 2 HOH 92  492 92  HOH HOH A . 
B 2 HOH 93  493 111 HOH HOH A . 
B 2 HOH 94  494 95  HOH HOH A . 
B 2 HOH 95  495 58  HOH HOH A . 
B 2 HOH 96  496 109 HOH HOH A . 
B 2 HOH 97  497 13  HOH HOH A . 
B 2 HOH 98  498 78  HOH HOH A . 
B 2 HOH 99  499 99  HOH HOH A . 
B 2 HOH 100 500 45  HOH HOH A . 
B 2 HOH 101 501 82  HOH HOH A . 
B 2 HOH 102 502 114 HOH HOH A . 
B 2 HOH 103 503 49  HOH HOH A . 
B 2 HOH 104 504 108 HOH HOH A . 
B 2 HOH 105 505 69  HOH HOH A . 
B 2 HOH 106 506 32  HOH HOH A . 
B 2 HOH 107 507 66  HOH HOH A . 
B 2 HOH 108 508 90  HOH HOH A . 
B 2 HOH 109 509 113 HOH HOH A . 
B 2 HOH 110 510 83  HOH HOH A . 
B 2 HOH 111 511 70  HOH HOH A . 
B 2 HOH 112 512 94  HOH HOH A . 
B 2 HOH 113 513 112 HOH HOH A . 
B 2 HOH 114 514 110 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A VAL 309 ? CG1 ? A VAL 309 CG1 
2 1 Y 1 A VAL 309 ? CG2 ? A VAL 309 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.11.1_2575 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8X6E 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     49.014 
_cell.length_a_esd                 ? 
_cell.length_b                     168.635 
_cell.length_b_esd                 ? 
_cell.length_c                     39.819 
_cell.length_c_esd                 ? 
_cell.volume                       329122.984 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8X6E 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8X6E 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.32 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          47.05 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Tris, pH 8.0, 25 % v/v PEG 400, 10% 0.1 M Magnesium chloride hexahydrate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-12-06 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97853 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97853 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          35.7409409771 
_reflns.entry_id                                       8X6E 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.0 
_reflns.d_resolution_low                               42.375 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     23207 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          28.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.0 
_reflns_shell.d_res_low                                     2.072 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1674 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.89 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               48.7252012689 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8X6E 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00002083763 
_refine.ls_d_res_low                             42.3746589575 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22793 
_refine.ls_number_reflns_R_free                  1127 
_refine.ls_number_reflns_R_work                  21666 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.3219739453 
_refine.ls_percent_reflns_R_free                 4.94450050454 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.213976070355 
_refine.ls_R_factor_R_free                       0.236303942258 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.212709230823 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33132083659 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.9899985566 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.247029643467 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00002083763 
_refine_hist.d_res_low                        42.3746589575 
_refine_hist.number_atoms_solvent             114 
_refine_hist.number_atoms_total               2449 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2335 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00360366541479 ? 2377 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.57768209664    ? 3217 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0378952380688  ? 373  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00401815387392 ? 412  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.550495878     ? 1448 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00002083763 2.091         . . 155 2674 99.2631578947 . . . . 0.307354963286 . . . . . . . . . . . 
0.335743089221 
'X-RAY DIFFRACTION' 2.091         2.2013        . . 129 2699 100.0         . . . . 0.252049682838 . . . . . . . . . . . 
0.332959232273 
'X-RAY DIFFRACTION' 2.2013        2.3392        . . 148 2373 87.595552467  . . . . 0.305501136689 . . . . . . . . . . . 
0.370850483544 
'X-RAY DIFFRACTION' 2.3392        2.5198        . . 118 2723 100.0         . . . . 0.232249340221 . . . . . . . . . . . 
0.244416552581 
'X-RAY DIFFRACTION' 2.5198        2.7733        . . 153 2698 99.9649368864 . . . . 0.234367354064 . . . . . . . . . . . 
0.236469176719 
'X-RAY DIFFRACTION' 2.7733        3.1745        . . 138 2758 100.0         . . . . 0.230243316517 . . . . . . . . . . . 
0.283740986477 
'X-RAY DIFFRACTION' 3.1745        3.9991        . . 128 2810 99.6607869742 . . . . 0.20274932593  . . . . . . . . . . . 
0.259252444259 
'X-RAY DIFFRACTION' 3.9991        42.3746589575 . . 158 2931 100.0         . . . . 0.177775976512 . . . . . . . . . . . 
0.172645802862 
# 
_struct.entry_id                     8X6E 
_struct.title                        'crystal structure of the N-terminal TBF1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8X6E 
_struct_keywords.text            'telomere, DNA damage response, gene transcription, DNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    TBF1_YEAST 
_struct_ref.pdbx_db_accession          Q02457 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MDSQVPNNNESLNRFNDIIQSLPARTRLTICSLCLLDNISTQLLRFLILNANSPNIIAVLTDQTAFLSSGETEIFQTLVK
LFKQIRMIYHTRSPLLSVHDVAPGLWFPNSPPPLILRGHEAFIITAIRKANLLTFLLTSLNCLNYGFELLQSIFLDIFCP
NTNTVGNNSLEQSGKFLKSQAILYLDLKTQAYIAGLKEFQDETNEISLEKKQELLDLIFPSNLADILVQRRTGDSGDITL
LTPSEKDFVERCDRRRENLKIVQDFNSLTQSYEWAQFIRELLDYCNKNMGLIIWGRKGRGKSPLYDFDVN
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8X6E 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 310 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q02457 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  310 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       310 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 11  ? ASN A 16  ? SER A 11  ASN A 16  5 ? 6  
HELX_P HELX_P2  AA2 ILE A 18  ? LEU A 22  ? ILE A 18  LEU A 22  5 ? 5  
HELX_P HELX_P3  AA3 PRO A 23  ? SER A 32  ? PRO A 23  SER A 32  1 ? 10 
HELX_P HELX_P4  AA4 SER A 32  ? ASN A 50  ? SER A 32  ASN A 50  1 ? 19 
HELX_P HELX_P5  AA5 PRO A 54  ? VAL A 59  ? PRO A 54  VAL A 59  1 ? 6  
HELX_P HELX_P6  AA6 GLY A 70  ? MET A 87  ? GLY A 70  MET A 87  1 ? 18 
HELX_P HELX_P7  AA7 SER A 97  ? ALA A 102 ? SER A 97  ALA A 102 1 ? 6  
HELX_P HELX_P8  AA8 PRO A 113 ? ARG A 117 ? PRO A 113 ARG A 117 5 ? 5  
HELX_P HELX_P9  AA9 HIS A 119 ? LEU A 140 ? HIS A 119 LEU A 140 1 ? 22 
HELX_P HELX_P10 AB1 PHE A 147 ? CYS A 159 ? PHE A 147 CYS A 159 1 ? 13 
HELX_P HELX_P11 AB2 LEU A 177 ? PHE A 199 ? LEU A 177 PHE A 199 1 ? 23 
HELX_P HELX_P12 AB3 SER A 207 ? PHE A 219 ? SER A 207 PHE A 219 1 ? 13 
HELX_P HELX_P13 AB4 ASN A 222 ? GLY A 233 ? ASN A 222 GLY A 233 1 ? 12 
HELX_P HELX_P14 AB5 ASP A 237 ? LEU A 241 ? ASP A 237 LEU A 241 5 ? 5  
HELX_P HELX_P15 AB6 THR A 242 ? ILE A 261 ? THR A 242 ILE A 261 1 ? 20 
HELX_P HELX_P16 AB7 ASP A 264 ? TYR A 272 ? ASP A 264 TYR A 272 1 ? 9  
HELX_P HELX_P17 AB8 GLU A 273 ? ASN A 288 ? GLU A 273 ASN A 288 1 ? 16 
HELX_P HELX_P18 AB9 ASN A 288 ? GLY A 295 ? ASN A 288 GLY A 295 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   8X6E 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 53  ? ? -175.73 -174.80 
2 1 PRO A 54  ? ? -68.76  78.49   
3 1 LEU A 60  ? ? -176.54 131.35  
4 1 LEU A 105 ? ? -123.49 -50.99  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x+1/2,y+1/2,-z 
4 -x,-y,z         
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       514 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.53 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ASP 2   ? A ASP 2   
3  1 Y 1 A SER 3   ? A SER 3   
4  1 Y 1 A GLN 4   ? A GLN 4   
5  1 Y 1 A VAL 5   ? A VAL 5   
6  1 Y 1 A PRO 6   ? A PRO 6   
7  1 Y 1 A THR 64  ? A THR 64  
8  1 Y 1 A ALA 65  ? A ALA 65  
9  1 Y 1 A PHE 66  ? A PHE 66  
10 1 Y 1 A LEU 67  ? A LEU 67  
11 1 Y 1 A SER 68  ? A SER 68  
12 1 Y 1 A ASN 163 ? A ASN 163 
13 1 Y 1 A THR 164 ? A THR 164 
14 1 Y 1 A VAL 165 ? A VAL 165 
15 1 Y 1 A GLY 166 ? A GLY 166 
16 1 Y 1 A ASN 167 ? A ASN 167 
17 1 Y 1 A ASN 168 ? A ASN 168 
18 1 Y 1 A SER 169 ? A SER 169 
19 1 Y 1 A LEU 170 ? A LEU 170 
20 1 Y 1 A GLU 171 ? A GLU 171 
21 1 Y 1 A ASN 310 ? A ASN 310 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Chinese Academy of Sciences' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6K5S 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 2' 
_space_group.name_Hall        'P 2 2ab' 
_space_group.IT_number        18 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8X6E 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020402 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005930 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.025114 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASN A 1 7   ? 9.29719   2.79870   -20.15016 1.000 73.96533  ? 7   ASN A N   1 
ATOM   2    C CA  . ASN A 1 7   ? 8.27344   1.80669   -19.84390 1.000 71.39099  ? 7   ASN A CA  1 
ATOM   3    C C   . ASN A 1 7   ? 6.98340   2.49039   -19.38972 1.000 71.26625  ? 7   ASN A C   1 
ATOM   4    O O   . ASN A 1 7   ? 7.02075   3.46736   -18.64021 1.000 66.61919  ? 7   ASN A O   1 
ATOM   5    C CB  . ASN A 1 7   ? 8.77374   0.83527   -18.77020 1.000 59.47684  ? 7   ASN A CB  1 
ATOM   6    C CG  . ASN A 1 7   ? 8.00488   -0.47022  -18.76151 1.000 68.87560  ? 7   ASN A CG  1 
ATOM   7    O OD1 . ASN A 1 7   ? 6.79312   -0.49319  -18.98031 1.000 75.21410  ? 7   ASN A OD1 1 
ATOM   8    N ND2 . ASN A 1 7   ? 8.71043   -1.57087  -18.51837 1.000 75.87771  ? 7   ASN A ND2 1 
ATOM   9    N N   . ASN A 1 8   ? 5.84441   1.97544   -19.85619 1.000 73.88068  ? 8   ASN A N   1 
ATOM   10   C CA  . ASN A 1 8   ? 4.53443   2.50365   -19.49560 1.000 68.59911  ? 8   ASN A CA  1 
ATOM   11   C C   . ASN A 1 8   ? 3.78560   1.62164   -18.50733 1.000 68.75856  ? 8   ASN A C   1 
ATOM   12   O O   . ASN A 1 8   ? 2.64563   1.94449   -18.15037 1.000 67.29393  ? 8   ASN A O   1 
ATOM   13   C CB  . ASN A 1 8   ? 3.67859   2.70584   -20.75169 1.000 76.07479  ? 8   ASN A CB  1 
ATOM   14   C CG  . ASN A 1 8   ? 3.66583   4.14807   -21.22087 1.000 87.30032  ? 8   ASN A CG  1 
ATOM   15   O OD1 . ASN A 1 8   ? 4.43698   4.97808   -20.73514 1.000 84.63600  ? 8   ASN A OD1 1 
ATOM   16   N ND2 . ASN A 1 8   ? 2.78713   4.45495   -22.17029 1.000 87.40944  ? 8   ASN A ND2 1 
ATOM   17   N N   . ASN A 1 9   ? 4.38587   0.51988   -18.06422 1.000 60.32644  ? 9   ASN A N   1 
ATOM   18   C CA  . ASN A 1 9   ? 3.76079   -0.34821  -17.07361 1.000 55.19808  ? 9   ASN A CA  1 
ATOM   19   C C   . ASN A 1 9   ? 3.76727   0.34023   -15.71171 1.000 53.22783  ? 9   ASN A C   1 
ATOM   20   O O   . ASN A 1 9   ? 4.83548   0.61519   -15.15320 1.000 50.80391  ? 9   ASN A O   1 
ATOM   21   C CB  . ASN A 1 9   ? 4.50715   -1.67928  -17.01389 1.000 57.94297  ? 9   ASN A CB  1 
ATOM   22   C CG  . ASN A 1 9   ? 3.67772   -2.79348  -16.40883 1.000 54.35977  ? 9   ASN A CG  1 
ATOM   23   O OD1 . ASN A 1 9   ? 2.81833   -2.55641  -15.56030 1.000 59.84784  ? 9   ASN A OD1 1 
ATOM   24   N ND2 . ASN A 1 9   ? 3.93346   -4.02186  -16.84550 1.000 56.59056  ? 9   ASN A ND2 1 
ATOM   25   N N   . GLU A 1 10  ? 2.57998   0.62983   -15.17702 1.000 51.14527  ? 10  GLU A N   1 
ATOM   26   C CA  . GLU A 1 10  ? 2.49024   1.29615   -13.88230 1.000 54.30916  ? 10  GLU A CA  1 
ATOM   27   C C   . GLU A 1 10  ? 2.61993   0.33988   -12.70316 1.000 48.15912  ? 10  GLU A C   1 
ATOM   28   O O   . GLU A 1 10  ? 2.73801   0.80397   -11.56386 1.000 50.24449  ? 10  GLU A O   1 
ATOM   29   C CB  . GLU A 1 10  ? 1.17036   2.06597   -13.75972 1.000 51.53255  ? 10  GLU A CB  1 
ATOM   30   C CG  . GLU A 1 10  ? 1.12147   3.36804   -14.54229 1.000 60.35495  ? 10  GLU A CG  1 
ATOM   31   C CD  . GLU A 1 10  ? 0.24728   3.26690   -15.77802 1.000 68.53173  ? 10  GLU A CD  1 
ATOM   32   O OE1 . GLU A 1 10  ? -0.05587  2.12851   -16.19896 1.000 66.05691  ? 10  GLU A OE1 1 
ATOM   33   O OE2 . GLU A 1 10  ? -0.14377  4.32396   -16.32119 1.000 74.78090  ? 10  GLU A OE2 1 
ATOM   34   N N   . SER A 1 11  ? 2.59799   -0.96812  -12.93570 1.000 41.56169  ? 11  SER A N   1 
ATOM   35   C CA  . SER A 1 11  ? 2.75171   -1.90541  -11.83877 1.000 36.53675  ? 11  SER A CA  1 
ATOM   36   C C   . SER A 1 11  ? 4.23225   -2.13231  -11.53875 1.000 38.17780  ? 11  SER A C   1 
ATOM   37   O O   . SER A 1 11  ? 5.12261   -1.65417  -12.24852 1.000 37.23528  ? 11  SER A O   1 
ATOM   38   C CB  . SER A 1 11  ? 2.06700   -3.23107  -12.16398 1.000 36.33322  ? 11  SER A CB  1 
ATOM   39   O OG  . SER A 1 11  ? 2.87651   -4.04023  -13.00156 1.000 35.44312  ? 11  SER A OG  1 
ATOM   40   N N   . LEU A 1 12  ? 4.48700   -2.89352  -10.47265 1.000 32.71439  ? 12  LEU A N   1 
ATOM   41   C CA  . LEU A 1 12  ? 5.85397   -3.24570  -10.10817 1.000 39.68189  ? 12  LEU A CA  1 
ATOM   42   C C   . LEU A 1 12  ? 6.54171   -4.06595  -11.18902 1.000 38.37260  ? 12  LEU A C   1 
ATOM   43   O O   . LEU A 1 12  ? 7.77208   -4.18046  -11.17053 1.000 34.78422  ? 12  LEU A O   1 
ATOM   44   C CB  . LEU A 1 12  ? 5.87863   -4.01949  -8.78526  1.000 32.81011  ? 12  LEU A CB  1 
ATOM   45   C CG  . LEU A 1 12  ? 5.55486   -5.51657  -8.82287  1.000 38.18648  ? 12  LEU A CG  1 
ATOM   46   C CD1 . LEU A 1 12  ? 5.87513   -6.16476  -7.47743  1.000 32.57130  ? 12  LEU A CD1 1 
ATOM   47   C CD2 . LEU A 1 12  ? 4.10330   -5.77303  -9.20786  1.000 34.18324  ? 12  LEU A CD2 1 
ATOM   48   N N   . ASN A 1 13  ? 5.78096   -4.63191  -12.13193 1.000 33.07509  ? 13  ASN A N   1 
ATOM   49   C CA  . ASN A 1 13  ? 6.39070   -5.40742  -13.20421 1.000 36.02883  ? 13  ASN A CA  1 
ATOM   50   C C   . ASN A 1 13  ? 7.27433   -4.55247  -14.10899 1.000 34.60936  ? 13  ASN A C   1 
ATOM   51   O O   . ASN A 1 13  ? 8.11707   -5.10267  -14.82568 1.000 34.03473  ? 13  ASN A O   1 
ATOM   52   C CB  . ASN A 1 13  ? 5.31458   -6.11009  -14.03020 1.000 33.56215  ? 13  ASN A CB  1 
ATOM   53   C CG  . ASN A 1 13  ? 4.65701   -7.25189  -13.27512 1.000 45.17728  ? 13  ASN A CG  1 
ATOM   54   O OD1 . ASN A 1 13  ? 5.28164   -8.28503  -13.01742 1.000 38.21685  ? 13  ASN A OD1 1 
ATOM   55   N ND2 . ASN A 1 13  ? 3.38840   -7.07244  -12.91781 1.000 39.33511  ? 13  ASN A ND2 1 
ATOM   56   N N   . ARG A 1 14  ? 7.11936   -3.22502  -14.07773 1.000 33.21394  ? 14  ARG A N   1 
ATOM   57   C CA  . ARG A 1 14  ? 7.98040   -2.36123  -14.88140 1.000 33.50119  ? 14  ARG A CA  1 
ATOM   58   C C   . ARG A 1 14  ? 9.45784   -2.53230  -14.53520 1.000 31.63596  ? 14  ARG A C   1 
ATOM   59   O O   . ARG A 1 14  ? 10.31695  -2.20785  -15.35994 1.000 32.97340  ? 14  ARG A O   1 
ATOM   60   C CB  . ARG A 1 14  ? 7.57254   -0.89191  -14.71225 1.000 37.02244  ? 14  ARG A CB  1 
ATOM   61   C CG  . ARG A 1 14  ? 7.87104   -0.29473  -13.33958 1.000 30.93974  ? 14  ARG A CG  1 
ATOM   62   C CD  . ARG A 1 14  ? 7.46989   1.17625   -13.25567 1.000 36.67239  ? 14  ARG A CD  1 
ATOM   63   N NE  . ARG A 1 14  ? 8.29337   2.02937   -14.11009 1.000 36.99080  ? 14  ARG A NE  1 
ATOM   64   C CZ  . ARG A 1 14  ? 7.84546   2.70443   -15.16447 1.000 40.13351  ? 14  ARG A CZ  1 
ATOM   65   N NH1 . ARG A 1 14  ? 6.56454   2.64354   -15.50246 1.000 42.18420  ? 14  ARG A NH1 1 
ATOM   66   N NH2 . ARG A 1 14  ? 8.67976   3.44895   -15.87851 1.000 38.49319  ? 14  ARG A NH2 1 
ATOM   67   N N   . PHE A 1 15  ? 9.76721   -3.04610  -13.34706 1.000 34.66652  ? 15  PHE A N   1 
ATOM   68   C CA  . PHE A 1 15  ? 11.13992  -3.21745  -12.89156 1.000 34.88654  ? 15  PHE A CA  1 
ATOM   69   C C   . PHE A 1 15  ? 11.66364  -4.63601  -13.08335 1.000 34.66639  ? 15  PHE A C   1 
ATOM   70   O O   . PHE A 1 15  ? 12.73783  -4.95524  -12.56923 1.000 39.57748  ? 15  PHE A O   1 
ATOM   71   C CB  . PHE A 1 15  ? 11.25599  -2.82953  -11.41338 1.000 34.22320  ? 15  PHE A CB  1 
ATOM   72   C CG  . PHE A 1 15  ? 10.75152  -1.44459  -11.10144 1.000 34.96859  ? 15  PHE A CG  1 
ATOM   73   C CD1 . PHE A 1 15  ? 11.43307  -0.32437  -11.55579 1.000 35.58986  ? 15  PHE A CD1 1 
ATOM   74   C CD2 . PHE A 1 15  ? 9.60613   -1.26343  -10.33596 1.000 34.61805  ? 15  PHE A CD2 1 
ATOM   75   C CE1 . PHE A 1 15  ? 10.97448  0.94649   -11.27018 1.000 34.10535  ? 15  PHE A CE1 1 
ATOM   76   C CE2 . PHE A 1 15  ? 9.14087   0.00814   -10.04644 1.000 34.58589  ? 15  PHE A CE2 1 
ATOM   77   C CZ  . PHE A 1 15  ? 9.82560   1.11616   -10.51087 1.000 36.42905  ? 15  PHE A CZ  1 
ATOM   78   N N   . ASN A 1 16  ? 10.94031  -5.49433  -13.81078 1.000 34.37428  ? 16  ASN A N   1 
ATOM   79   C CA  . ASN A 1 16  ? 11.31414  -6.90792  -13.86442 1.000 36.76071  ? 16  ASN A CA  1 
ATOM   80   C C   . ASN A 1 16  ? 12.70077  -7.11711  -14.46933 1.000 40.95324  ? 16  ASN A C   1 
ATOM   81   O O   . ASN A 1 16  ? 13.40450  -8.05931  -14.08606 1.000 36.04061  ? 16  ASN A O   1 
ATOM   82   C CB  . ASN A 1 16  ? 10.27318  -7.70791  -14.65344 1.000 34.98081  ? 16  ASN A CB  1 
ATOM   83   C CG  . ASN A 1 16  ? 8.96377   -7.88504  -13.89486 1.000 41.09357  ? 16  ASN A CG  1 
ATOM   84   O OD1 . ASN A 1 16  ? 8.90060   -7.68563  -12.68300 1.000 37.88609  ? 16  ASN A OD1 1 
ATOM   85   N ND2 . ASN A 1 16  ? 7.91530   -8.27711  -14.60849 1.000 39.46363  ? 16  ASN A ND2 1 
ATOM   86   N N   . ASP A 1 17  ? 13.10849  -6.25762  -15.40944 1.000 36.16023  ? 17  ASP A N   1 
ATOM   87   C CA  . ASP A 1 17  ? 14.40108  -6.42623  -16.06862 1.000 45.47018  ? 17  ASP A CA  1 
ATOM   88   C C   . ASP A 1 17  ? 15.56830  -6.16529  -15.12619 1.000 42.78556  ? 17  ASP A C   1 
ATOM   89   O O   . ASP A 1 17  ? 16.66507  -6.69062  -15.34543 1.000 47.86285  ? 17  ASP A O   1 
ATOM   90   C CB  . ASP A 1 17  ? 14.50673  -5.49904  -17.28026 1.000 47.45717  ? 17  ASP A CB  1 
ATOM   91   C CG  . ASP A 1 17  ? 13.67784  -5.97446  -18.45405 1.000 60.27140  ? 17  ASP A CG  1 
ATOM   92   O OD1 . ASP A 1 17  ? 13.13619  -7.09948  -18.38777 1.000 65.42829  ? 17  ASP A OD1 1 
ATOM   93   O OD2 . ASP A 1 17  ? 13.56956  -5.21975  -19.44411 1.000 71.54933  ? 17  ASP A OD2 1 
ATOM   94   N N   . ILE A 1 18  ? 15.36435  -5.35833  -14.08638 1.000 41.30798  ? 18  ILE A N   1 
ATOM   95   C CA  . ILE A 1 18  ? 16.44895  -4.97102  -13.18724 1.000 40.45067  ? 18  ILE A CA  1 
ATOM   96   C C   . ILE A 1 18  ? 16.28594  -5.52347  -11.78202 1.000 40.88377  ? 18  ILE A C   1 
ATOM   97   O O   . ILE A 1 18  ? 17.21726  -5.39074  -10.97408 1.000 39.29734  ? 18  ILE A O   1 
ATOM   98   C CB  . ILE A 1 18  ? 16.60800  -3.43890  -13.12180 1.000 36.03479  ? 18  ILE A CB  1 
ATOM   99   C CG1 . ILE A 1 18  ? 15.36437  -2.80220  -12.49646 1.000 37.01936  ? 18  ILE A CG1 1 
ATOM   100  C CG2 . ILE A 1 18  ? 16.86282  -2.86368  -14.50858 1.000 34.79980  ? 18  ILE A CG2 1 
ATOM   101  C CD1 . ILE A 1 18  ? 15.52641  -1.33302  -12.20349 1.000 41.04129  ? 18  ILE A CD1 1 
ATOM   102  N N   . ILE A 1 19  ? 15.15592  -6.16216  -11.46868 1.000 39.97372  ? 19  ILE A N   1 
ATOM   103  C CA  . ILE A 1 19  ? 14.81140  -6.43443  -10.07427 1.000 36.84722  ? 19  ILE A CA  1 
ATOM   104  C C   . ILE A 1 19  ? 15.84213  -7.34965  -9.41558  1.000 42.48618  ? 19  ILE A C   1 
ATOM   105  O O   . ILE A 1 19  ? 16.20160  -7.16108  -8.24639  1.000 39.03174  ? 19  ILE A O   1 
ATOM   106  C CB  . ILE A 1 19  ? 13.38374  -7.01130  -9.99044  1.000 41.52696  ? 19  ILE A CB  1 
ATOM   107  C CG1 . ILE A 1 19  ? 12.87949  -6.97102  -8.55086  1.000 37.87626  ? 19  ILE A CG1 1 
ATOM   108  C CG2 . ILE A 1 19  ? 13.30607  -8.41025  -10.60001 1.000 40.52191  ? 19  ILE A CG2 1 
ATOM   109  C CD1 . ILE A 1 19  ? 12.65897  -5.56615  -8.04988  1.000 36.38798  ? 19  ILE A CD1 1 
ATOM   110  N N   . GLN A 1 20  ? 16.35166  -8.33910  -10.14890 1.000 42.44251  ? 20  GLN A N   1 
ATOM   111  C CA  . GLN A 1 20  ? 17.30540  -9.26113  -9.54644  1.000 44.11292  ? 20  GLN A CA  1 
ATOM   112  C C   . GLN A 1 20  ? 18.70605  -8.67100  -9.44107  1.000 44.06983  ? 20  GLN A C   1 
ATOM   113  O O   . GLN A 1 20  ? 19.52461  -9.19115  -8.67606  1.000 47.98370  ? 20  GLN A O   1 
ATOM   114  C CB  . GLN A 1 20  ? 17.32678  -10.57276 -10.33008 1.000 46.71986  ? 20  GLN A CB  1 
ATOM   115  C CG  . GLN A 1 20  ? 16.02605  -11.36346 -10.19702 1.000 50.38146  ? 20  GLN A CG  1 
ATOM   116  C CD  . GLN A 1 20  ? 15.64063  -11.61887 -8.74008  1.000 65.03926  ? 20  GLN A CD  1 
ATOM   117  O OE1 . GLN A 1 20  ? 14.53551  -11.27457 -8.30022  1.000 56.00724  ? 20  GLN A OE1 1 
ATOM   118  N NE2 . GLN A 1 20  ? 16.55388  -12.22580 -7.98587  1.000 60.09869  ? 20  GLN A NE2 1 
ATOM   119  N N   . SER A 1 21  ? 18.99168  -7.59132  -10.16942 1.000 45.64227  ? 21  SER A N   1 
ATOM   120  C CA  . SER A 1 21  ? 20.26560  -6.89314  -10.05401 1.000 45.99293  ? 21  SER A CA  1 
ATOM   121  C C   . SER A 1 21  ? 20.35334  -6.01711  -8.81117  1.000 48.36311  ? 21  SER A C   1 
ATOM   122  O O   . SER A 1 21  ? 21.42441  -5.46094  -8.54109  1.000 45.89659  ? 21  SER A O   1 
ATOM   123  C CB  . SER A 1 21  ? 20.50321  -6.02251  -11.29125 1.000 42.17096  ? 21  SER A CB  1 
ATOM   124  O OG  . SER A 1 21  ? 20.50771  -6.80039  -12.47416 1.000 52.98148  ? 21  SER A OG  1 
ATOM   125  N N   . LEU A 1 22  ? 19.25613  -5.86931  -8.05817  1.000 43.35697  ? 22  LEU A N   1 
ATOM   126  C CA  . LEU A 1 22  ? 19.20417  -4.96199  -6.92340  1.000 37.50099  ? 22  LEU A CA  1 
ATOM   127  C C   . LEU A 1 22  ? 19.28354  -5.73860  -5.61280  1.000 33.61239  ? 22  LEU A C   1 
ATOM   128  O O   . LEU A 1 22  ? 18.84606  -6.88767  -5.54253  1.000 37.93304  ? 22  LEU A O   1 
ATOM   129  C CB  . LEU A 1 22  ? 17.90987  -4.13428  -6.93925  1.000 35.76538  ? 22  LEU A CB  1 
ATOM   130  C CG  . LEU A 1 22  ? 17.63444  -3.28152  -8.17943  1.000 36.34561  ? 22  LEU A CG  1 
ATOM   131  C CD1 . LEU A 1 22  ? 16.26528  -2.62077  -8.08465  1.000 42.18932  ? 22  LEU A CD1 1 
ATOM   132  C CD2 . LEU A 1 22  ? 18.72362  -2.23140  -8.35735  1.000 34.76751  ? 22  LEU A CD2 1 
ATOM   133  N N   . PRO A 1 23  ? 19.83070  -5.14536  -4.55720  1.000 34.49591  ? 23  PRO A N   1 
ATOM   134  C CA  . PRO A 1 23  ? 19.77129  -5.79989  -3.24859  1.000 36.33081  ? 23  PRO A CA  1 
ATOM   135  C C   . PRO A 1 23  ? 18.33656  -5.87984  -2.75240  1.000 38.90077  ? 23  PRO A C   1 
ATOM   136  O O   . PRO A 1 23  ? 17.47422  -5.08629  -3.14241  1.000 31.81668  ? 23  PRO A O   1 
ATOM   137  C CB  . PRO A 1 23  ? 20.62638  -4.89837  -2.35282  1.000 35.90399  ? 23  PRO A CB  1 
ATOM   138  C CG  . PRO A 1 23  ? 20.60927  -3.56727  -3.02631  1.000 40.93333  ? 23  PRO A CG  1 
ATOM   139  C CD  . PRO A 1 23  ? 20.52824  -3.84859  -4.50158  1.000 37.30166  ? 23  PRO A CD  1 
ATOM   140  N N   . ALA A 1 24  ? 18.09875  -6.85811  -1.87452  1.000 36.02758  ? 24  ALA A N   1 
ATOM   141  C CA  . ALA A 1 24  ? 16.74611  -7.18715  -1.43677  1.000 42.25919  ? 24  ALA A CA  1 
ATOM   142  C C   . ALA A 1 24  ? 15.98961  -5.96034  -0.93602  1.000 38.57674  ? 24  ALA A C   1 
ATOM   143  O O   . ALA A 1 24  ? 14.82119  -5.75238  -1.28519  1.000 37.95837  ? 24  ALA A O   1 
ATOM   144  C CB  . ALA A 1 24  ? 16.80616  -8.26063  -0.35139  1.000 40.35365  ? 24  ALA A CB  1 
ATOM   145  N N   . ARG A 1 25  ? 16.63555  -5.13433  -0.11158  1.000 31.93275  ? 25  ARG A N   1 
ATOM   146  C CA  . ARG A 1 25  ? 15.92633  -3.98548  0.44069   1.000 36.54390  ? 25  ARG A CA  1 
ATOM   147  C C   . ARG A 1 25  ? 15.63222  -2.94058  -0.62856  1.000 38.54256  ? 25  ARG A C   1 
ATOM   148  O O   . ARG A 1 25  ? 14.61681  -2.23806  -0.54172  1.000 35.88823  ? 25  ARG A O   1 
ATOM   149  C CB  . ARG A 1 25  ? 16.71345  -3.37202  1.60058   1.000 38.16042  ? 25  ARG A CB  1 
ATOM   150  C CG  . ARG A 1 25  ? 16.06337  -2.11268  2.16995   1.000 52.35648  ? 25  ARG A CG  1 
ATOM   151  C CD  . ARG A 1 25  ? 16.07295  -2.06543  3.69370   1.000 52.08924  ? 25  ARG A CD  1 
ATOM   152  N NE  . ARG A 1 25  ? 14.72138  -2.02145  4.25555   1.000 55.46704  ? 25  ARG A NE  1 
ATOM   153  C CZ  . ARG A 1 25  ? 13.92877  -0.94931  4.24240   1.000 58.30449  ? 25  ARG A CZ  1 
ATOM   154  N NH1 . ARG A 1 25  ? 14.33740  0.18447   3.68414   1.000 47.68971  ? 25  ARG A NH1 1 
ATOM   155  N NH2 . ARG A 1 25  ? 12.71649  -1.01312  4.78106   1.000 49.73644  ? 25  ARG A NH2 1 
ATOM   156  N N   . THR A 1 26  ? 16.47810  -2.83392  -1.65444  1.000 33.01784  ? 26  THR A N   1 
ATOM   157  C CA  . THR A 1 26  ? 16.15963  -1.91306  -2.73916  1.000 33.40030  ? 26  THR A CA  1 
ATOM   158  C C   . THR A 1 26  ? 15.05041  -2.46744  -3.63335  1.000 32.81497  ? 26  THR A C   1 
ATOM   159  O O   . THR A 1 26  ? 14.29604  -1.68717  -4.22861  1.000 29.98467  ? 26  THR A O   1 
ATOM   160  C CB  . THR A 1 26  ? 17.42121  -1.57762  -3.54191  1.000 37.07098  ? 26  THR A CB  1 
ATOM   161  O OG1 . THR A 1 26  ? 18.40635  -1.02453  -2.65923  1.000 35.26538  ? 26  THR A OG1 1 
ATOM   162  C CG2 . THR A 1 26  ? 17.11898  -0.53900  -4.62261  1.000 32.87506  ? 26  THR A CG2 1 
ATOM   163  N N   . ARG A 1 27  ? 14.92001  -3.79624  -3.73118  1.000 28.25252  ? 27  ARG A N   1 
ATOM   164  C CA  . ARG A 1 27  ? 13.72726  -4.36280  -4.35776  1.000 34.54048  ? 27  ARG A CA  1 
ATOM   165  C C   . ARG A 1 27  ? 12.47105  -3.88837  -3.64393  1.000 34.09856  ? 27  ARG A C   1 
ATOM   166  O O   . ARG A 1 27  ? 11.47648  -3.52700  -4.28625  1.000 32.60622  ? 27  ARG A O   1 
ATOM   167  C CB  . ARG A 1 27  ? 13.76056  -5.89239  -4.33985  1.000 34.99587  ? 27  ARG A CB  1 
ATOM   168  C CG  . ARG A 1 27  ? 14.87723  -6.53228  -5.12279  1.000 44.63620  ? 27  ARG A CG  1 
ATOM   169  C CD  . ARG A 1 27  ? 14.61951  -8.03293  -5.28194  1.000 43.81718  ? 27  ARG A CD  1 
ATOM   170  N NE  . ARG A 1 27  ? 15.83566  -8.74789  -5.65125  1.000 45.04815  ? 27  ARG A NE  1 
ATOM   171  C CZ  . ARG A 1 27  ? 16.46076  -9.61725  -4.86407  1.000 53.98219  ? 27  ARG A CZ  1 
ATOM   172  N NH1 . ARG A 1 27  ? 15.97246  -9.90180  -3.66364  1.000 45.85244  ? 27  ARG A NH1 1 
ATOM   173  N NH2 . ARG A 1 27  ? 17.56929  -10.21420 -5.28453  1.000 57.86576  ? 27  ARG A NH2 1 
ATOM   174  N N   . LEU A 1 28  ? 12.50073  -3.90075  -2.31068  1.000 30.71120  ? 28  LEU A N   1 
ATOM   175  C CA  . LEU A 1 28  ? 11.35703  -3.46024  -1.52578  1.000 34.40285  ? 28  LEU A CA  1 
ATOM   176  C C   . LEU A 1 28  ? 11.05977  -1.98310  -1.76088  1.000 31.43696  ? 28  LEU A C   1 
ATOM   177  O O   . LEU A 1 28  ? 9.91963   -1.61506  -2.05957  1.000 27.59881  ? 28  LEU A O   1 
ATOM   178  C CB  . LEU A 1 28  ? 11.61007  -3.73426  -0.04404  1.000 30.78437  ? 28  LEU A CB  1 
ATOM   179  C CG  . LEU A 1 28  ? 10.58695  -3.13649  0.92357   1.000 37.14785  ? 28  LEU A CG  1 
ATOM   180  C CD1 . LEU A 1 28  ? 9.28718   -3.94797  0.90262   1.000 33.19622  ? 28  LEU A CD1 1 
ATOM   181  C CD2 . LEU A 1 28  ? 11.15342  -3.06312  2.32661   1.000 35.66425  ? 28  LEU A CD2 1 
ATOM   182  N N   . THR A 1 29  ? 12.07401  -1.11480  -1.64105  1.000 27.13703  ? 29  THR A N   1 
ATOM   183  C CA  . THR A 1 29  ? 11.81251  0.31727   -1.79052  1.000 29.86482  ? 29  THR A CA  1 
ATOM   184  C C   . THR A 1 29  ? 11.41794  0.67314   -3.21944  1.000 31.53933  ? 29  THR A C   1 
ATOM   185  O O   . THR A 1 29  ? 10.60336  1.58317   -3.42713  1.000 34.11438  ? 29  THR A O   1 
ATOM   186  C CB  . THR A 1 29  ? 13.02447  1.15125   -1.34048  1.000 34.94021  ? 29  THR A CB  1 
ATOM   187  O OG1 . THR A 1 29  ? 14.18308  0.80400   -2.11045  1.000 31.11353  ? 29  THR A OG1 1 
ATOM   188  C CG2 . THR A 1 29  ? 13.31648  0.90731   0.13693   1.000 33.72558  ? 29  THR A CG2 1 
ATOM   189  N N   . ILE A 1 30  ? 11.95254  -0.03998  -4.21036  1.000 27.60054  ? 30  ILE A N   1 
ATOM   190  C CA  . ILE A 1 30  ? 11.59981  0.23405   -5.60046  1.000 28.15958  ? 30  ILE A CA  1 
ATOM   191  C C   . ILE A 1 30  ? 10.18821  -0.25824  -5.91190  1.000 31.11288  ? 30  ILE A C   1 
ATOM   192  O O   . ILE A 1 30  ? 9.37328   0.47430   -6.48343  1.000 30.00624  ? 30  ILE A O   1 
ATOM   193  C CB  . ILE A 1 30  ? 12.63762  -0.39370  -6.54743  1.000 34.91861  ? 30  ILE A CB  1 
ATOM   194  C CG1 . ILE A 1 30  ? 13.92673  0.43748   -6.56790  1.000 39.52389  ? 30  ILE A CG1 1 
ATOM   195  C CG2 . ILE A 1 30  ? 12.06909  -0.53984  -7.95197  1.000 37.95222  ? 30  ILE A CG2 1 
ATOM   196  C CD1 . ILE A 1 30  ? 13.77079  1.78489   -7.24241  1.000 41.00761  ? 30  ILE A CD1 1 
ATOM   197  N N   . CYS A 1 31  ? 9.88126   -1.50927  -5.55811  1.000 29.02476  ? 31  CYS A N   1 
ATOM   198  C CA  . CYS A 1 31  ? 8.55776   -2.05065  -5.85455  1.000 28.75205  ? 31  CYS A CA  1 
ATOM   199  C C   . CYS A 1 31  ? 7.46997   -1.33105  -5.07637  1.000 27.58219  ? 31  CYS A C   1 
ATOM   200  O O   . CYS A 1 31  ? 6.35600   -1.16754  -5.58721  1.000 31.15845  ? 31  CYS A O   1 
ATOM   201  C CB  . CYS A 1 31  ? 8.51377   -3.54797  -5.55632  1.000 26.82412  ? 31  CYS A CB  1 
ATOM   202  S SG  . CYS A 1 31  ? 9.48136   -4.51737  -6.71678  1.000 34.60266  ? 31  CYS A SG  1 
ATOM   203  N N   . SER A 1 32  ? 7.77476   -0.88373  -3.85637  1.000 26.87878  ? 32  SER A N   1 
ATOM   204  C CA  . SER A 1 32  ? 6.79315   -0.19599  -3.03331  1.000 26.81582  ? 32  SER A CA  1 
ATOM   205  C C   . SER A 1 32  ? 6.52972   1.22698   -3.49756  1.000 31.12105  ? 32  SER A C   1 
ATOM   206  O O   . SER A 1 32  ? 5.66622   1.89111   -2.91746  1.000 28.26394  ? 32  SER A O   1 
ATOM   207  C CB  . SER A 1 32  ? 7.24323   -0.18774  -1.57322  1.000 28.13798  ? 32  SER A CB  1 
ATOM   208  O OG  . SER A 1 32  ? 7.41205   -1.51133  -1.09638  1.000 25.04623  ? 32  SER A OG  1 
ATOM   209  N N   . LEU A 1 33  ? 7.24958   1.70933   -4.51986  1.000 29.22859  ? 33  LEU A N   1 
ATOM   210  C CA  . LEU A 1 33  ? 6.91238   3.00243   -5.10934  1.000 31.50312  ? 33  LEU A CA  1 
ATOM   211  C C   . LEU A 1 33  ? 5.50164   3.00488   -5.67227  1.000 26.58475  ? 33  LEU A C   1 
ATOM   212  O O   . LEU A 1 33  ? 4.86920   4.06185   -5.75502  1.000 26.29840  ? 33  LEU A O   1 
ATOM   213  C CB  . LEU A 1 33  ? 7.90113   3.35949   -6.21889  1.000 30.61989  ? 33  LEU A CB  1 
ATOM   214  C CG  . LEU A 1 33  ? 9.24995   3.93251   -5.80058  1.000 38.15639  ? 33  LEU A CG  1 
ATOM   215  C CD1 . LEU A 1 33  ? 10.13380  4.00630   -7.02597  1.000 39.71242  ? 33  LEU A CD1 1 
ATOM   216  C CD2 . LEU A 1 33  ? 9.07577   5.30065   -5.16909  1.000 34.81493  ? 33  LEU A CD2 1 
ATOM   217  N N   . CYS A 1 34  ? 5.01653   1.84143   -6.11060  1.000 27.42844  ? 34  CYS A N   1 
ATOM   218  C CA  . CYS A 1 34  ? 3.64567   1.74366   -6.59241  1.000 27.52270  ? 34  CYS A CA  1 
ATOM   219  C C   . CYS A 1 34  ? 2.65717   1.93149   -5.45333  1.000 28.92170  ? 34  CYS A C   1 
ATOM   220  O O   . CYS A 1 34  ? 1.61294   2.56669   -5.63404  1.000 28.26475  ? 34  CYS A O   1 
ATOM   221  C CB  . CYS A 1 34  ? 3.42457   0.39784   -7.27828  1.000 30.84599  ? 34  CYS A CB  1 
ATOM   222  S SG  . CYS A 1 34  ? 4.59468   0.05953   -8.62357  1.000 36.13213  ? 34  CYS A SG  1 
ATOM   223  N N   . LEU A 1 35  ? 2.96101   1.36871   -4.28005  1.000 25.00300  ? 35  LEU A N   1 
ATOM   224  C CA  . LEU A 1 35  ? 2.15929   1.63919   -3.08946  1.000 26.31651  ? 35  LEU A CA  1 
ATOM   225  C C   . LEU A 1 35  ? 2.16466   3.12475   -2.75981  1.000 26.92152  ? 35  LEU A C   1 
ATOM   226  O O   . LEU A 1 35  ? 1.11756   3.71823   -2.47462  1.000 23.39950  ? 35  LEU A O   1 
ATOM   227  C CB  . LEU A 1 35  ? 2.69803   0.84140   -1.90129  1.000 23.84632  ? 35  LEU A CB  1 
ATOM   228  C CG  . LEU A 1 35  ? 2.82227   -0.67212  -2.03642  1.000 27.90375  ? 35  LEU A CG  1 
ATOM   229  C CD1 . LEU A 1 35  ? 3.38698   -1.25314  -0.75106  1.000 23.29875  ? 35  LEU A CD1 1 
ATOM   230  C CD2 . LEU A 1 35  ? 1.46250   -1.28991  -2.36217  1.000 23.35854  ? 35  LEU A CD2 1 
ATOM   231  N N   . LEU A 1 36  ? 3.35058   3.73485   -2.78134  1.000 26.05684  ? 36  LEU A N   1 
ATOM   232  C CA  . LEU A 1 36  ? 3.49387   5.13385   -2.39553  1.000 26.20304  ? 36  LEU A CA  1 
ATOM   233  C C   . LEU A 1 36  ? 2.80826   6.06059   -3.38796  1.000 28.29704  ? 36  LEU A C   1 
ATOM   234  O O   . LEU A 1 36  ? 2.22608   7.07364   -2.99050  1.000 26.78708  ? 36  LEU A O   1 
ATOM   235  C CB  . LEU A 1 36  ? 4.97223   5.49777   -2.28579  1.000 24.96702  ? 36  LEU A CB  1 
ATOM   236  C CG  . LEU A 1 36  ? 5.29271   6.91319   -1.80186  1.000 28.97658  ? 36  LEU A CG  1 
ATOM   237  C CD1 . LEU A 1 36  ? 4.99719   7.06163   -0.31645  1.000 31.39222  ? 36  LEU A CD1 1 
ATOM   238  C CD2 . LEU A 1 36  ? 6.76621   7.25936   -2.09823  1.000 29.44935  ? 36  LEU A CD2 1 
ATOM   239  N N   . ASP A 1 37  ? 2.90498   5.75684   -4.68560  1.000 27.17857  ? 37  ASP A N   1 
ATOM   240  C CA  . ASP A 1 37  ? 2.21650   6.57463   -5.67563  1.000 27.32450  ? 37  ASP A CA  1 
ATOM   241  C C   . ASP A 1 37  ? 0.70177   6.41509   -5.57444  1.000 25.16342  ? 37  ASP A C   1 
ATOM   242  O O   . ASP A 1 37  ? -0.03914  7.39949   -5.68728  1.000 26.99692  ? 37  ASP A O   1 
ATOM   243  C CB  . ASP A 1 37  ? 2.70239   6.22481   -7.08037  1.000 29.03753  ? 37  ASP A CB  1 
ATOM   244  C CG  . ASP A 1 37  ? 2.15230   7.16646   -8.12971  1.000 36.76572  ? 37  ASP A CG  1 
ATOM   245  O OD1 . ASP A 1 37  ? 0.94539   7.08048   -8.43712  1.000 50.45016  ? 37  ASP A OD1 1 
ATOM   246  O OD2 . ASP A 1 37  ? 2.91290   8.02423   -8.61950  1.000 43.40031  ? 37  ASP A OD2 1 
ATOM   247  N N   . ASN A 1 38  ? 0.22057   5.18808   -5.35912  1.000 26.37695  ? 38  ASN A N   1 
ATOM   248  C CA  . ASN A 1 38  ? -1.22258  4.96893   -5.27782  1.000 28.69954  ? 38  ASN A CA  1 
ATOM   249  C C   . ASN A 1 38  ? -1.81501  5.66753   -4.06296  1.000 26.82236  ? 38  ASN A C   1 
ATOM   250  O O   . ASN A 1 38  ? -2.77666  6.43980   -4.18352  1.000 30.11237  ? 38  ASN A O   1 
ATOM   251  C CB  . ASN A 1 38  ? -1.53804  3.46750   -5.23571  1.000 25.59785  ? 38  ASN A CB  1 
ATOM   252  C CG  . ASN A 1 38  ? -3.01942  3.19229   -4.97823  1.000 29.28294  ? 38  ASN A CG  1 
ATOM   253  O OD1 . ASN A 1 38  ? -3.49819  3.32299   -3.85336  1.000 24.85790  ? 38  ASN A OD1 1 
ATOM   254  N ND2 . ASN A 1 38  ? -3.74902  2.82281   -6.02774  1.000 29.00844  ? 38  ASN A ND2 1 
ATOM   255  N N   . ILE A 1 39  ? -1.26213  5.40821   -2.87669  1.000 24.29512  ? 39  ILE A N   1 
ATOM   256  C CA  . ILE A 1 39  ? -1.85018  5.99066   -1.67420  1.000 23.14597  ? 39  ILE A CA  1 
ATOM   257  C C   . ILE A 1 39  ? -1.74124  7.50870   -1.71427  1.000 28.17758  ? 39  ILE A C   1 
ATOM   258  O O   . ILE A 1 39  ? -2.65325  8.21772   -1.27426  1.000 25.52251  ? 39  ILE A O   1 
ATOM   259  C CB  . ILE A 1 39  ? -1.21445  5.40255   -0.39588  1.000 27.06894  ? 39  ILE A CB  1 
ATOM   260  C CG1 . ILE A 1 39  ? -2.08162  5.72935   0.82009   1.000 23.67181  ? 39  ILE A CG1 1 
ATOM   261  C CG2 . ILE A 1 39  ? 0.23269   5.91425   -0.18191  1.000 24.66539  ? 39  ILE A CG2 1 
ATOM   262  C CD1 . ILE A 1 39  ? -3.45118  5.09548   0.75197   1.000 30.15005  ? 39  ILE A CD1 1 
ATOM   263  N N   . SER A 1 40  ? -0.64533  8.03975   -2.26674  1.000 24.01240  ? 40  SER A N   1 
ATOM   264  C CA  . SER A 1 40  ? -0.52512  9.49321   -2.35679  1.000 25.39082  ? 40  SER A CA  1 
ATOM   265  C C   . SER A 1 40  ? -1.56351  10.07391  -3.31461  1.000 26.64313  ? 40  SER A C   1 
ATOM   266  O O   . SER A 1 40  ? -2.15522  11.12326  -3.04183  1.000 24.96149  ? 40  SER A O   1 
ATOM   267  C CB  . SER A 1 40  ? 0.88922   9.88390   -2.78663  1.000 29.53461  ? 40  SER A CB  1 
ATOM   268  O OG  . SER A 1 40  ? 1.83315   9.49280   -1.79898  1.000 25.08925  ? 40  SER A OG  1 
ATOM   269  N N   . THR A 1 41  ? -1.79864  9.40284   -4.44116  1.000 30.79765  ? 41  THR A N   1 
ATOM   270  C CA  . THR A 1 41  ? -2.80287  9.88957   -5.37720  1.000 28.84175  ? 41  THR A CA  1 
ATOM   271  C C   . THR A 1 41  ? -4.20156  9.80618   -4.76824  1.000 25.89087  ? 41  THR A C   1 
ATOM   272  O O   . THR A 1 41  ? -4.99004  10.74773  -4.89296  1.000 29.16757  ? 41  THR A O   1 
ATOM   273  C CB  . THR A 1 41  ? -2.71379  9.10691   -6.69239  1.000 33.01894  ? 41  THR A CB  1 
ATOM   274  O OG1 . THR A 1 41  ? -1.36677  9.15746   -7.18941  1.000 27.55322  ? 41  THR A OG1 1 
ATOM   275  C CG2 . THR A 1 41  ? -3.63839  9.71524   -7.73944  1.000 31.88725  ? 41  THR A CG2 1 
ATOM   276  N N   . GLN A 1 42  ? -4.52235  8.69654   -4.09447  1.000 27.17528  ? 42  GLN A N   1 
ATOM   277  C CA  . GLN A 1 42  ? -5.82006  8.57931   -3.43343  1.000 34.22169  ? 42  GLN A CA  1 
ATOM   278  C C   . GLN A 1 42  ? -6.03934  9.72689   -2.45390  1.000 32.26484  ? 42  GLN A C   1 
ATOM   279  O O   . GLN A 1 42  ? -7.10878  10.34144  -2.42900  1.000 27.71745  ? 42  GLN A O   1 
ATOM   280  C CB  . GLN A 1 42  ? -5.93896  7.23744   -2.70222  1.000 28.85861  ? 42  GLN A CB  1 
ATOM   281  C CG  . GLN A 1 42  ? -6.29695  6.03391   -3.57792  1.000 27.72028  ? 42  GLN A CG  1 
ATOM   282  C CD  . GLN A 1 42  ? -6.86588  4.88886   -2.76489  1.000 30.86931  ? 42  GLN A CD  1 
ATOM   283  O OE1 . GLN A 1 42  ? -7.98230  4.98473   -2.23725  1.000 29.63300  ? 42  GLN A OE1 1 
ATOM   284  N NE2 . GLN A 1 42  ? -6.10008  3.79803   -2.64633  1.000 25.28409  ? 42  GLN A NE2 1 
ATOM   285  N N   . LEU A 1 43  ? -5.02990  10.03473  -1.63898  1.000 26.76823  ? 43  LEU A N   1 
ATOM   286  C CA  . LEU A 1 43  ? -5.22456  11.01375  -0.57455  1.000 27.25464  ? 43  LEU A CA  1 
ATOM   287  C C   . LEU A 1 43  ? -5.18258  12.44597  -1.10438  1.000 29.64920  ? 43  LEU A C   1 
ATOM   288  O O   . LEU A 1 43  ? -5.91577  13.31269  -0.60917  1.000 33.49782  ? 43  LEU A O   1 
ATOM   289  C CB  . LEU A 1 43  ? -4.17994  10.80031  0.52306   1.000 25.95523  ? 43  LEU A CB  1 
ATOM   290  C CG  . LEU A 1 43  ? -4.29498  11.61596  1.80862   1.000 31.44366  ? 43  LEU A CG  1 
ATOM   291  C CD1 . LEU A 1 43  ? -5.72387  11.61162  2.34826   1.000 24.55134  ? 43  LEU A CD1 1 
ATOM   292  C CD2 . LEU A 1 43  ? -3.33266  11.05576  2.84941   1.000 34.91677  ? 43  LEU A CD2 1 
ATOM   293  N N   . LEU A 1 44  ? -4.34266  12.72080  -2.10663  1.000 26.31469  ? 44  LEU A N   1 
ATOM   294  C CA  . LEU A 1 44  ? -4.37357  14.04016  -2.73525  1.000 29.21216  ? 44  LEU A CA  1 
ATOM   295  C C   . LEU A 1 44  ? -5.72530  14.28497  -3.40268  1.000 30.22368  ? 44  LEU A C   1 
ATOM   296  O O   . LEU A 1 44  ? -6.31905  15.35996  -3.25290  1.000 29.24565  ? 44  LEU A O   1 
ATOM   297  C CB  . LEU A 1 44  ? -3.23504  14.18416  -3.75006  1.000 27.17382  ? 44  LEU A CB  1 
ATOM   298  C CG  . LEU A 1 44  ? -1.79728  14.31424  -3.22291  1.000 24.44034  ? 44  LEU A CG  1 
ATOM   299  C CD1 . LEU A 1 44  ? -0.79569  14.20305  -4.36003  1.000 25.22981  ? 44  LEU A CD1 1 
ATOM   300  C CD2 . LEU A 1 44  ? -1.61376  15.64915  -2.48681  1.000 24.92590  ? 44  LEU A CD2 1 
ATOM   301  N N   . ARG A 1 45  ? -6.22388  13.28942  -4.14641  1.000 33.09223  ? 45  ARG A N   1 
ATOM   302  C CA  . ARG A 1 45  ? -7.57125  13.35794  -4.72093  1.000 32.33558  ? 45  ARG A CA  1 
ATOM   303  C C   . ARG A 1 45  ? -8.61053  13.69120  -3.66195  1.000 32.77029  ? 45  ARG A C   1 
ATOM   304  O O   . ARG A 1 45  ? -9.40815  14.62418  -3.81718  1.000 39.42658  ? 45  ARG A O   1 
ATOM   305  C CB  . ARG A 1 45  ? -7.93710  12.02238  -5.37118  1.000 30.17051  ? 45  ARG A CB  1 
ATOM   306  C CG  . ARG A 1 45  ? -7.34433  11.74648  -6.73025  1.000 32.81112  ? 45  ARG A CG  1 
ATOM   307  C CD  . ARG A 1 45  ? -7.79783  10.36618  -7.18797  1.000 29.03353  ? 45  ARG A CD  1 
ATOM   308  N NE  . ARG A 1 45  ? -7.29479  10.01013  -8.50823  1.000 29.43798  ? 45  ARG A NE  1 
ATOM   309  C CZ  . ARG A 1 45  ? -7.71427  8.96149   -9.20766  1.000 33.99648  ? 45  ARG A CZ  1 
ATOM   310  N NH1 . ARG A 1 45  ? -8.65661  8.16568   -8.71580  1.000 31.92473  ? 45  ARG A NH1 1 
ATOM   311  N NH2 . ARG A 1 45  ? -7.20042  8.71706   -10.40545 1.000 30.12427  ? 45  ARG A NH2 1 
ATOM   312  N N   . PHE A 1 46  ? -8.62853  12.90276  -2.58794  1.000 30.01095  ? 46  PHE A N   1 
ATOM   313  C CA  . PHE A 1 46  ? -9.58546  13.09288  -1.50427  1.000 29.90286  ? 46  PHE A CA  1 
ATOM   314  C C   . PHE A 1 46  ? -9.50770  14.50649  -0.92989  1.000 39.13518  ? 46  PHE A C   1 
ATOM   315  O O   . PHE A 1 46  ? -10.53863 15.14771  -0.69188  1.000 36.06794  ? 46  PHE A O   1 
ATOM   316  C CB  . PHE A 1 46  ? -9.32184  12.04111  -0.42577  1.000 30.77511  ? 46  PHE A CB  1 
ATOM   317  C CG  . PHE A 1 46  ? -10.30938 12.05834  0.70769   1.000 40.64172  ? 46  PHE A CG  1 
ATOM   318  C CD1 . PHE A 1 46  ? -10.12686 12.90448  1.79342   1.000 38.12811  ? 46  PHE A CD1 1 
ATOM   319  C CD2 . PHE A 1 46  ? -11.41726 11.22060  0.69312   1.000 37.47574  ? 46  PHE A CD2 1 
ATOM   320  C CE1 . PHE A 1 46  ? -11.02878 12.91510  2.83428   1.000 38.82886  ? 46  PHE A CE1 1 
ATOM   321  C CE2 . PHE A 1 46  ? -12.32014 11.22855  1.73644   1.000 36.84267  ? 46  PHE A CE2 1 
ATOM   322  C CZ  . PHE A 1 46  ? -12.12550 12.07759  2.80502   1.000 36.41105  ? 46  PHE A CZ  1 
ATOM   323  N N   . LEU A 1 47  ? -8.28946  15.00805  -0.69696  1.000 30.80871  ? 47  LEU A N   1 
ATOM   324  C CA  . LEU A 1 47  ? -8.12388  16.33411  -0.10511  1.000 29.72357  ? 47  LEU A CA  1 
ATOM   325  C C   . LEU A 1 47  ? -8.65615  17.42034  -1.03038  1.000 36.35444  ? 47  LEU A C   1 
ATOM   326  O O   . LEU A 1 47  ? -9.35168  18.34213  -0.58999  1.000 39.69105  ? 47  LEU A O   1 
ATOM   327  C CB  . LEU A 1 47  ? -6.65008  16.59012  0.21824   1.000 34.63079  ? 47  LEU A CB  1 
ATOM   328  C CG  . LEU A 1 47  ? -6.03999  15.88254  1.42983   1.000 36.22818  ? 47  LEU A CG  1 
ATOM   329  C CD1 . LEU A 1 47  ? -4.53023  16.11028  1.47701   1.000 33.74184  ? 47  LEU A CD1 1 
ATOM   330  C CD2 . LEU A 1 47  ? -6.69363  16.35811  2.71637   1.000 36.13014  ? 47  LEU A CD2 1 
ATOM   331  N N   . ILE A 1 48  ? -8.33325  17.33254  -2.32052  1.000 37.02941  ? 48  ILE A N   1 
ATOM   332  C CA  . ILE A 1 48  ? -8.85197  18.30239  -3.27986  1.000 39.31158  ? 48  ILE A CA  1 
ATOM   333  C C   . ILE A 1 48  ? -10.36859 18.17563  -3.40089  1.000 46.01174  ? 48  ILE A C   1 
ATOM   334  O O   . ILE A 1 48  ? -11.09295 19.17749  -3.38638  1.000 45.38533  ? 48  ILE A O   1 
ATOM   335  C CB  . ILE A 1 48  ? -8.15886  18.13741  -4.64419  1.000 37.58723  ? 48  ILE A CB  1 
ATOM   336  C CG1 . ILE A 1 48  ? -6.89782  18.99594  -4.71913  1.000 38.30602  ? 48  ILE A CG1 1 
ATOM   337  C CG2 . ILE A 1 48  ? -9.08903  18.55871  -5.76649  1.000 48.24743  ? 48  ILE A CG2 1 
ATOM   338  C CD1 . ILE A 1 48  ? -5.82778  18.63169  -3.75403  1.000 45.10004  ? 48  ILE A CD1 1 
ATOM   339  N N   . LEU A 1 49  ? -10.87169 16.94127  -3.50987  1.000 42.35432  ? 49  LEU A N   1 
ATOM   340  C CA  . LEU A 1 49  ? -12.30889 16.73438  -3.68078  1.000 44.98647  ? 49  LEU A CA  1 
ATOM   341  C C   . LEU A 1 49  ? -13.10815 17.31513  -2.52040  1.000 53.70094  ? 49  LEU A C   1 
ATOM   342  O O   . LEU A 1 49  ? -14.24413 17.76611  -2.71375  1.000 54.37780  ? 49  LEU A O   1 
ATOM   343  C CB  . LEU A 1 49  ? -12.61455 15.24104  -3.83894  1.000 42.50096  ? 49  LEU A CB  1 
ATOM   344  C CG  . LEU A 1 49  ? -14.07700 14.84025  -4.05590  1.000 47.89746  ? 49  LEU A CG  1 
ATOM   345  C CD1 . LEU A 1 49  ? -14.57498 15.35483  -5.39197  1.000 48.31936  ? 49  LEU A CD1 1 
ATOM   346  C CD2 . LEU A 1 49  ? -14.25672 13.32737  -3.95906  1.000 46.88548  ? 49  LEU A CD2 1 
ATOM   347  N N   . ASN A 1 50  ? -12.53125 17.33628  -1.31787  1.000 50.80286  ? 50  ASN A N   1 
ATOM   348  C CA  . ASN A 1 50  ? -13.23393 17.78172  -0.12115  1.000 51.76542  ? 50  ASN A CA  1 
ATOM   349  C C   . ASN A 1 50  ? -12.73418 19.13370  0.38374   1.000 52.93088  ? 50  ASN A C   1 
ATOM   350  O O   . ASN A 1 50  ? -12.92143 19.45892  1.56017   1.000 61.58562  ? 50  ASN A O   1 
ATOM   351  C CB  . ASN A 1 50  ? -13.11847 16.71963  0.97502   1.000 44.97558  ? 50  ASN A CB  1 
ATOM   352  C CG  . ASN A 1 50  ? -13.85023 15.43646  0.62285   1.000 54.10447  ? 50  ASN A CG  1 
ATOM   353  O OD1 . ASN A 1 50  ? -15.07450 15.35394  0.74283   1.000 56.68876  ? 50  ASN A OD1 1 
ATOM   354  N ND2 . ASN A 1 50  ? -13.10365 14.42509  0.18892   1.000 45.23509  ? 50  ASN A ND2 1 
ATOM   355  N N   . ALA A 1 51  ? -12.12104 19.93866  -0.49057  1.000 49.26583  ? 51  ALA A N   1 
ATOM   356  C CA  . ALA A 1 51  ? -11.48441 21.17586  -0.04397  1.000 54.93114  ? 51  ALA A CA  1 
ATOM   357  C C   . ALA A 1 51  ? -12.49705 22.25383  0.34197   1.000 69.93249  ? 51  ALA A C   1 
ATOM   358  O O   . ALA A 1 51  ? -12.18939 23.11445  1.17437   1.000 72.28606  ? 51  ALA A O   1 
ATOM   359  C CB  . ALA A 1 51  ? -10.54621 21.70330  -1.13003  1.000 47.13224  ? 51  ALA A CB  1 
ATOM   360  N N   . ASN A 1 52  ? -13.69040 22.24087  -0.24515  1.000 67.90933  ? 52  ASN A N   1 
ATOM   361  C CA  . ASN A 1 52  ? -14.71026 23.25868  0.01625   1.000 76.60492  ? 52  ASN A CA  1 
ATOM   362  C C   . ASN A 1 52  ? -15.88470 22.59331  0.73371   1.000 82.84315  ? 52  ASN A C   1 
ATOM   363  O O   . ASN A 1 52  ? -16.80570 22.07303  0.09900   1.000 83.42476  ? 52  ASN A O   1 
ATOM   364  C CB  . ASN A 1 52  ? -15.14895 23.93506  -1.27649  1.000 74.57942  ? 52  ASN A CB  1 
ATOM   365  C CG  . ASN A 1 52  ? -14.01055 24.66566  -1.96732  1.000 75.09286  ? 52  ASN A CG  1 
ATOM   366  O OD1 . ASN A 1 52  ? -13.01270 25.01972  -1.33985  1.000 71.34365  ? 52  ASN A OD1 1 
ATOM   367  N ND2 . ASN A 1 52  ? -14.15634 24.89489  -3.26649  1.000 78.91032  ? 52  ASN A ND2 1 
ATOM   368  N N   . SER A 1 53  ? -15.85402 22.63855  2.06571   1.000 86.84884  ? 53  SER A N   1 
ATOM   369  C CA  . SER A 1 53  ? -16.82731 21.96993  2.92077   1.000 88.61515  ? 53  SER A CA  1 
ATOM   370  C C   . SER A 1 53  ? -16.53081 22.33567  4.37147   1.000 92.92647  ? 53  SER A C   1 
ATOM   371  O O   . SER A 1 53  ? -15.66008 23.17885  4.62271   1.000 89.03339  ? 53  SER A O   1 
ATOM   372  C CB  . SER A 1 53  ? -16.75608 20.45392  2.71519   1.000 89.72119  ? 53  SER A CB  1 
ATOM   373  O OG  . SER A 1 53  ? -15.56750 19.92153  3.27648   1.000 86.07023  ? 53  SER A OG  1 
ATOM   374  N N   . PRO A 1 54  ? -17.23478 21.75276  5.35865   1.000 98.66422  ? 54  PRO A N   1 
ATOM   375  C CA  . PRO A 1 54  ? -16.67281 21.72537  6.71632   1.000 94.54314  ? 54  PRO A CA  1 
ATOM   376  C C   . PRO A 1 54  ? -15.46405 20.80453  6.76927   1.000 92.68225  ? 54  PRO A C   1 
ATOM   377  O O   . PRO A 1 54  ? -15.56346 19.65877  7.22121   1.000 89.34236  ? 54  PRO A O   1 
ATOM   378  C CB  . PRO A 1 54  ? -17.83118 21.20080  7.57604   1.000 96.52798  ? 54  PRO A CB  1 
ATOM   379  C CG  . PRO A 1 54  ? -18.74941 20.51743  6.61082   1.000 101.58305 ? 54  PRO A CG  1 
ATOM   380  C CD  . PRO A 1 54  ? -18.64266 21.31425  5.34780   1.000 97.84519  ? 54  PRO A CD  1 
ATOM   381  N N   . ASN A 1 55  ? -14.31934 21.29295  6.28841   1.000 91.22549  ? 55  ASN A N   1 
ATOM   382  C CA  . ASN A 1 55  ? -13.13707 20.45264  6.15052   1.000 85.95844  ? 55  ASN A CA  1 
ATOM   383  C C   . ASN A 1 55  ? -12.25221 20.48399  7.38920   1.000 81.62869  ? 55  ASN A C   1 
ATOM   384  O O   . ASN A 1 55  ? -11.71227 19.44387  7.77696   1.000 81.49792  ? 55  ASN A O   1 
ATOM   385  C CB  . ASN A 1 55  ? -12.32849 20.86927  4.91586   1.000 86.88237  ? 55  ASN A CB  1 
ATOM   386  C CG  . ASN A 1 55  ? -11.58076 22.17282  5.11683   1.000 85.52656  ? 55  ASN A CG  1 
ATOM   387  O OD1 . ASN A 1 55  ? -10.41209 22.17553  5.50403   1.000 79.62603  ? 55  ASN A OD1 1 
ATOM   388  N ND2 . ASN A 1 55  ? -12.25385 23.28980  4.86114   1.000 90.75562  ? 55  ASN A ND2 1 
ATOM   389  N N   . ILE A 1 56  ? -12.09528 21.65162  8.02354   1.000 80.37115  ? 56  ILE A N   1 
ATOM   390  C CA  . ILE A 1 56  ? -11.31563 21.73489  9.25810   1.000 79.13380  ? 56  ILE A CA  1 
ATOM   391  C C   . ILE A 1 56  ? -11.80906 20.70362  10.25941  1.000 84.42703  ? 56  ILE A C   1 
ATOM   392  O O   . ILE A 1 56  ? -11.02403 20.14654  11.03834  1.000 80.34935  ? 56  ILE A O   1 
ATOM   393  C CB  . ILE A 1 56  ? -11.37832 23.16435  9.83859   1.000 82.18176  ? 56  ILE A CB  1 
ATOM   394  C CG1 . ILE A 1 56  ? -10.93897 24.19442  8.79344   1.000 73.23222  ? 56  ILE A CG1 1 
ATOM   395  C CG2 . ILE A 1 56  ? -10.51377 23.27481  11.08788  1.000 79.63789  ? 56  ILE A CG2 1 
ATOM   396  C CD1 . ILE A 1 56  ? -9.48470  24.07676  8.38657   1.000 67.58222  ? 56  ILE A CD1 1 
ATOM   397  N N   . ILE A 1 57  ? -13.10922 20.41183  10.23373  1.000 80.61463  ? 57  ILE A N   1 
ATOM   398  C CA  . ILE A 1 57  ? -13.66628 19.34709  11.05782  1.000 83.25173  ? 57  ILE A CA  1 
ATOM   399  C C   . ILE A 1 57  ? -13.32932 17.98026  10.47586  1.000 78.67280  ? 57  ILE A C   1 
ATOM   400  O O   . ILE A 1 57  ? -12.78252 17.11455  11.16887  1.000 78.36512  ? 57  ILE A O   1 
ATOM   401  C CB  . ILE A 1 57  ? -15.18875 19.53366  11.19980  1.000 89.72548  ? 57  ILE A CB  1 
ATOM   402  C CG1 . ILE A 1 57  ? -15.51008 20.90913  11.79288  1.000 90.28950  ? 57  ILE A CG1 1 
ATOM   403  C CG2 . ILE A 1 57  ? -15.79186 18.40942  12.03635  1.000 86.97832  ? 57  ILE A CG2 1 
ATOM   404  C CD1 . ILE A 1 57  ? -16.36207 21.78247  10.88833  1.000 81.09068  ? 57  ILE A CD1 1 
ATOM   405  N N   . ALA A 1 58  ? -13.63940 17.77491  9.19007   1.000 80.93830  ? 58  ALA A N   1 
ATOM   406  C CA  . ALA A 1 58  ? -13.59883 16.43325  8.61037   1.000 77.37396  ? 58  ALA A CA  1 
ATOM   407  C C   . ALA A 1 58  ? -12.18736 15.86018  8.60070   1.000 67.28800  ? 58  ALA A C   1 
ATOM   408  O O   . ALA A 1 58  ? -11.98527 14.69240  8.95249   1.000 64.84675  ? 58  ALA A O   1 
ATOM   409  C CB  . ALA A 1 58  ? -14.17961 16.45056  7.19626   1.000 75.99914  ? 58  ALA A CB  1 
ATOM   410  N N   . VAL A 1 59  ? -11.19902 16.65163  8.19838   1.000 68.71835  ? 59  VAL A N   1 
ATOM   411  C CA  . VAL A 1 59  ? -9.81671  16.18812  8.19344   1.000 63.50791  ? 59  VAL A CA  1 
ATOM   412  C C   . VAL A 1 59  ? -9.25113  16.37994  9.60040   1.000 65.15601  ? 59  VAL A C   1 
ATOM   413  O O   . VAL A 1 59  ? -9.23844  17.49284  10.14121  1.000 77.92700  ? 59  VAL A O   1 
ATOM   414  C CB  . VAL A 1 59  ? -8.97975  16.89006  7.10400   1.000 65.79834  ? 59  VAL A CB  1 
ATOM   415  C CG1 . VAL A 1 59  ? -9.86487  17.65535  6.12619   1.000 61.72661  ? 59  VAL A CG1 1 
ATOM   416  C CG2 . VAL A 1 59  ? -7.86547  17.77854  7.66343   1.000 70.25751  ? 59  VAL A CG2 1 
ATOM   417  N N   . LEU A 1 60  ? -8.86119  15.26572  10.22213  1.000 65.44695  ? 60  LEU A N   1 
ATOM   418  C CA  . LEU A 1 60  ? -8.39137  15.21693  11.60098  1.000 69.43223  ? 60  LEU A CA  1 
ATOM   419  C C   . LEU A 1 60  ? -7.95699  13.79350  11.92784  1.000 68.21723  ? 60  LEU A C   1 
ATOM   420  O O   . LEU A 1 60  ? -8.68912  12.83984  11.64358  1.000 65.56081  ? 60  LEU A O   1 
ATOM   421  C CB  . LEU A 1 60  ? -9.48131  15.68064  12.57618  1.000 67.88553  ? 60  LEU A CB  1 
ATOM   422  C CG  . LEU A 1 60  ? -9.14518  15.63630  14.06975  1.000 68.77833  ? 60  LEU A CG  1 
ATOM   423  C CD1 . LEU A 1 60  ? -7.92948  16.49905  14.37594  1.000 76.16247  ? 60  LEU A CD1 1 
ATOM   424  C CD2 . LEU A 1 60  ? -10.34088 16.06911  14.91442  1.000 78.39563  ? 60  LEU A CD2 1 
ATOM   425  N N   . THR A 1 61  ? -6.76857  13.63579  12.50988  1.000 70.89817  ? 61  THR A N   1 
ATOM   426  C CA  . THR A 1 61  ? -6.26575  12.32047  12.89266  1.000 75.19765  ? 61  THR A CA  1 
ATOM   427  C C   . THR A 1 61  ? -6.83851  11.81764  14.20968  1.000 70.81506  ? 61  THR A C   1 
ATOM   428  O O   . THR A 1 61  ? -6.50383  10.70220  14.62190  1.000 69.73825  ? 61  THR A O   1 
ATOM   429  C CB  . THR A 1 61  ? -4.73672  12.33839  13.00337  1.000 68.05553  ? 61  THR A CB  1 
ATOM   430  O OG1 . THR A 1 61  ? -4.30801  13.57618  13.58876  1.000 63.24806  ? 61  THR A OG1 1 
ATOM   431  C CG2 . THR A 1 61  ? -4.09536  12.14885  11.64247  1.000 60.41772  ? 61  THR A CG2 1 
ATOM   432  N N   . ASP A 1 62  ? -7.68123  12.59749  14.87731  1.000 70.34631  ? 62  ASP A N   1 
ATOM   433  C CA  . ASP A 1 62  ? -8.11250  12.29023  16.23303  1.000 76.53216  ? 62  ASP A CA  1 
ATOM   434  C C   . ASP A 1 62  ? -9.53210  11.73553  16.22652  1.000 80.67830  ? 62  ASP A C   1 
ATOM   435  O O   . ASP A 1 62  ? -10.41542 12.27345  15.54887  1.000 77.56213  ? 62  ASP A O   1 
ATOM   436  C CB  . ASP A 1 62  ? -8.01164  13.53391  17.11739  1.000 73.87815  ? 62  ASP A CB  1 
ATOM   437  C CG  . ASP A 1 62  ? -6.57148  13.99270  17.30890  1.000 78.15561  ? 62  ASP A CG  1 
ATOM   438  O OD1 . ASP A 1 62  ? -5.97588  14.51856  16.34376  1.000 84.41310  ? 62  ASP A OD1 1 
ATOM   439  O OD2 . ASP A 1 62  ? -6.02923  13.81346  18.42039  1.000 71.81966  ? 62  ASP A OD2 1 
ATOM   440  N N   . GLN A 1 63  ? -9.73952  10.65748  16.97919  1.000 82.31211  ? 63  GLN A N   1 
ATOM   441  C CA  . GLN A 1 63  ? -11.02935 9.97518   17.04662  1.000 83.51211  ? 63  GLN A CA  1 
ATOM   442  C C   . GLN A 1 63  ? -11.88619 10.47963  18.20558  1.000 76.12174  ? 63  GLN A C   1 
ATOM   443  O O   . GLN A 1 63  ? -11.72785 11.61105  18.66520  1.000 78.35741  ? 63  GLN A O   1 
ATOM   444  C CB  . GLN A 1 63  ? -10.82156 8.46472   17.17841  1.000 82.82952  ? 63  GLN A CB  1 
ATOM   445  C CG  . GLN A 1 63  ? -10.12715 7.81969   15.98789  1.000 83.74616  ? 63  GLN A CG  1 
ATOM   446  C CD  . GLN A 1 63  ? -11.00621 6.79437   15.29011  1.000 99.19762  ? 63  GLN A CD  1 
ATOM   447  O OE1 . GLN A 1 63  ? -11.99011 7.14522   14.63451  1.000 94.92725  ? 63  GLN A OE1 1 
ATOM   448  N NE2 . GLN A 1 63  ? -10.65915 5.51791   15.43593  1.000 96.51438  ? 63  GLN A NE2 1 
ATOM   449  N N   . SER A 1 69  ? -17.87771 10.65044  11.10623  1.000 67.59549  ? 69  SER A N   1 
ATOM   450  C CA  . SER A 1 69  ? -18.24811 10.88316  9.71240   1.000 66.95376  ? 69  SER A CA  1 
ATOM   451  C C   . SER A 1 69  ? -17.64336 9.82194   8.79262   1.000 67.31259  ? 69  SER A C   1 
ATOM   452  O O   . SER A 1 69  ? -16.51623 9.37057   9.00729   1.000 62.93552  ? 69  SER A O   1 
ATOM   453  C CB  . SER A 1 69  ? -17.80996 12.28257  9.26906   1.000 60.22807  ? 69  SER A CB  1 
ATOM   454  O OG  . SER A 1 69  ? -17.49629 12.30524  7.88885   1.000 65.98954  ? 69  SER A OG  1 
ATOM   455  N N   . GLY A 1 70  ? -18.40485 9.42400   7.76949   1.000 65.89620  ? 70  GLY A N   1 
ATOM   456  C CA  . GLY A 1 70  ? -17.90733 8.43012   6.83111   1.000 60.69873  ? 70  GLY A CA  1 
ATOM   457  C C   . GLY A 1 70  ? -16.70194 8.91701   6.05053   1.000 55.61543  ? 70  GLY A C   1 
ATOM   458  O O   . GLY A 1 70  ? -15.76652 8.15362   5.79392   1.000 50.79009  ? 70  GLY A O   1 
ATOM   459  N N   . GLU A 1 71  ? -16.70914 10.19462  5.65828   1.000 50.41770  ? 71  GLU A N   1 
ATOM   460  C CA  . GLU A 1 71  ? -15.54122 10.77214  5.00335   1.000 52.21608  ? 71  GLU A CA  1 
ATOM   461  C C   . GLU A 1 71  ? -14.35624 10.85671  5.95598   1.000 53.36436  ? 71  GLU A C   1 
ATOM   462  O O   . GLU A 1 71  ? -13.20493 10.76033  5.51757   1.000 47.92905  ? 71  GLU A O   1 
ATOM   463  C CB  . GLU A 1 71  ? -15.87436 12.15830  4.44830   1.000 53.26814  ? 71  GLU A CB  1 
ATOM   464  C CG  . GLU A 1 71  ? -17.09607 12.19514  3.53478   1.000 59.31506  ? 71  GLU A CG  1 
ATOM   465  C CD  . GLU A 1 71  ? -16.80091 11.70327  2.12553   1.000 63.69083  ? 71  GLU A CD  1 
ATOM   466  O OE1 . GLU A 1 71  ? -15.68270 11.95128  1.62504   1.000 59.33020  ? 71  GLU A OE1 1 
ATOM   467  O OE2 . GLU A 1 71  ? -17.68739 11.06717  1.51519   1.000 67.63847  ? 71  GLU A OE2 1 
ATOM   468  N N   . THR A 1 72  ? -14.61378 11.03487  7.25614   1.000 55.71439  ? 72  THR A N   1 
ATOM   469  C CA  . THR A 1 72  ? -13.52340 11.05474  8.22808   1.000 51.90909  ? 72  THR A CA  1 
ATOM   470  C C   . THR A 1 72  ? -12.90082 9.67106   8.38341   1.000 47.03745  ? 72  THR A C   1 
ATOM   471  O O   . THR A 1 72  ? -11.67323 9.54103   8.45541   1.000 45.99472  ? 72  THR A O   1 
ATOM   472  C CB  . THR A 1 72  ? -14.02511 11.57852  9.57667   1.000 56.85984  ? 72  THR A CB  1 
ATOM   473  O OG1 . THR A 1 72  ? -14.38064 12.96123  9.45291   1.000 63.41672  ? 72  THR A OG1 1 
ATOM   474  C CG2 . THR A 1 72  ? -12.94687 11.44112  10.64249  1.000 54.94109  ? 72  THR A CG2 1 
ATOM   475  N N   . GLU A 1 73  ? -13.73079 8.62690   8.43395   1.000 44.03562  ? 73  GLU A N   1 
ATOM   476  C CA  . GLU A 1 73  ? -13.20543 7.26609   8.49668   1.000 47.99557  ? 73  GLU A CA  1 
ATOM   477  C C   . GLU A 1 73  ? -12.35507 6.95254   7.27265   1.000 44.29799  ? 73  GLU A C   1 
ATOM   478  O O   . GLU A 1 73  ? -11.31903 6.28714   7.38049   1.000 44.64765  ? 73  GLU A O   1 
ATOM   479  C CB  . GLU A 1 73  ? -14.35407 6.26190   8.62949   1.000 48.08406  ? 73  GLU A CB  1 
ATOM   480  C CG  . GLU A 1 73  ? -13.90717 4.80712   8.81454   1.000 54.33947  ? 73  GLU A CG  1 
ATOM   481  C CD  . GLU A 1 73  ? -13.67817 4.07057   7.49773   1.000 60.30891  ? 73  GLU A CD  1 
ATOM   482  O OE1 . GLU A 1 73  ? -14.54253 4.16809   6.59561   1.000 54.99711  ? 73  GLU A OE1 1 
ATOM   483  O OE2 . GLU A 1 73  ? -12.62578 3.40117   7.36422   1.000 62.23765  ? 73  GLU A OE2 1 
ATOM   484  N N   . ILE A 1 74  ? -12.77446 7.42708   6.10006   1.000 43.19789  ? 74  ILE A N   1 
ATOM   485  C CA  . ILE A 1 74  ? -11.98162 7.22742   4.89174   1.000 41.63051  ? 74  ILE A CA  1 
ATOM   486  C C   . ILE A 1 74  ? -10.68277 8.01831   4.97152   1.000 40.79275  ? 74  ILE A C   1 
ATOM   487  O O   . ILE A 1 74  ? -9.60630  7.50642   4.64525   1.000 33.79654  ? 74  ILE A O   1 
ATOM   488  C CB  . ILE A 1 74  ? -12.80009 7.60714   3.64642   1.000 41.66539  ? 74  ILE A CB  1 
ATOM   489  C CG1 . ILE A 1 74  ? -13.89998 6.56904   3.40620   1.000 35.27846  ? 74  ILE A CG1 1 
ATOM   490  C CG2 . ILE A 1 74  ? -11.89293 7.75307   2.43306   1.000 34.84966  ? 74  ILE A CG2 1 
ATOM   491  C CD1 . ILE A 1 74  ? -14.92996 7.00179   2.39033   1.000 42.34605  ? 74  ILE A CD1 1 
ATOM   492  N N   . PHE A 1 75  ? -10.76443 9.27735   5.40977   1.000 39.22872  ? 75  PHE A N   1 
ATOM   493  C CA  . PHE A 1 75  ? -9.56238  10.09450  5.54755   1.000 36.38592  ? 75  PHE A CA  1 
ATOM   494  C C   . PHE A 1 75  ? -8.57029  9.45501   6.50877   1.000 37.97171  ? 75  PHE A C   1 
ATOM   495  O O   . PHE A 1 75  ? -7.36894  9.39242   6.22048   1.000 38.53544  ? 75  PHE A O   1 
ATOM   496  C CB  . PHE A 1 75  ? -9.93310  11.50424  6.01242   1.000 37.84088  ? 75  PHE A CB  1 
ATOM   497  C CG  . PHE A 1 75  ? -8.74477  12.39413  6.28729   1.000 35.94528  ? 75  PHE A CG  1 
ATOM   498  C CD1 . PHE A 1 75  ? -7.94897  12.85529  5.24970   1.000 35.08235  ? 75  PHE A CD1 1 
ATOM   499  C CD2 . PHE A 1 75  ? -8.43650  12.78504  7.57987   1.000 40.99794  ? 75  PHE A CD2 1 
ATOM   500  C CE1 . PHE A 1 75  ? -6.85527  13.68005  5.49668   1.000 37.43598  ? 75  PHE A CE1 1 
ATOM   501  C CE2 . PHE A 1 75  ? -7.35036  13.61591  7.83340   1.000 43.11109  ? 75  PHE A CE2 1 
ATOM   502  C CZ  . PHE A 1 75  ? -6.55799  14.06061  6.78904   1.000 38.91259  ? 75  PHE A CZ  1 
ATOM   503  N N   . GLN A 1 76  ? -9.05391  8.95831   7.64841   1.000 31.56644  ? 76  GLN A N   1 
ATOM   504  C CA  . GLN A 1 76  ? -8.15077  8.37389   8.63318   1.000 39.59588  ? 76  GLN A CA  1 
ATOM   505  C C   . GLN A 1 76  ? -7.55533  7.06089   8.14407   1.000 37.48897  ? 76  GLN A C   1 
ATOM   506  O O   . GLN A 1 76  ? -6.39172  6.76181   8.44122   1.000 37.66577  ? 76  GLN A O   1 
ATOM   507  C CB  . GLN A 1 76  ? -8.88134  8.18010   9.96000   1.000 38.50720  ? 76  GLN A CB  1 
ATOM   508  C CG  . GLN A 1 76  ? -9.25831  9.49684   10.61981  1.000 43.33578  ? 76  GLN A CG  1 
ATOM   509  C CD  . GLN A 1 76  ? -10.00242 9.30958   11.91917  1.000 51.04414  ? 76  GLN A CD  1 
ATOM   510  O OE1 . GLN A 1 76  ? -10.32955 8.18937   12.30371  1.000 53.53197  ? 76  GLN A OE1 1 
ATOM   511  N NE2 . GLN A 1 76  ? -10.26986 10.41054  12.60950  1.000 64.10017  ? 76  GLN A NE2 1 
ATOM   512  N N   . THR A 1 77  ? -8.32809  6.27065   7.39743   1.000 32.31718  ? 77  THR A N   1 
ATOM   513  C CA  . THR A 1 77  ? -7.78531  5.05663   6.80172   1.000 32.19952  ? 77  THR A CA  1 
ATOM   514  C C   . THR A 1 77  ? -6.69098  5.39518   5.79954   1.000 32.74145  ? 77  THR A C   1 
ATOM   515  O O   . THR A 1 77  ? -5.63097  4.75891   5.78174   1.000 35.97932  ? 77  THR A O   1 
ATOM   516  C CB  . THR A 1 77  ? -8.90740  4.25262   6.13662   1.000 36.86064  ? 77  THR A CB  1 
ATOM   517  O OG1 . THR A 1 77  ? -9.79636  3.75675   7.14167   1.000 42.05107  ? 77  THR A OG1 1 
ATOM   518  C CG2 . THR A 1 77  ? -8.34567  3.07683   5.34806   1.000 36.47514  ? 77  THR A CG2 1 
ATOM   519  N N   . LEU A 1 78  ? -6.92656  6.41318   4.96398   1.000 28.34805  ? 78  LEU A N   1 
ATOM   520  C CA  . LEU A 1 78  ? -5.92465  6.82011   3.98059   1.000 29.96565  ? 78  LEU A CA  1 
ATOM   521  C C   . LEU A 1 78  ? -4.66947  7.37122   4.64977   1.000 31.92567  ? 78  LEU A C   1 
ATOM   522  O O   . LEU A 1 78  ? -3.54829  7.04370   4.24350   1.000 30.13720  ? 78  LEU A O   1 
ATOM   523  C CB  . LEU A 1 78  ? -6.51473  7.86030   3.02967   1.000 30.55964  ? 78  LEU A CB  1 
ATOM   524  C CG  . LEU A 1 78  ? -7.49534  7.36975   1.96413   1.000 34.49485  ? 78  LEU A CG  1 
ATOM   525  C CD1 . LEU A 1 78  ? -8.14851  8.55094   1.25210   1.000 35.97483  ? 78  LEU A CD1 1 
ATOM   526  C CD2 . LEU A 1 78  ? -6.78614  6.46325   0.97114   1.000 29.01438  ? 78  LEU A CD2 1 
ATOM   527  N N   . VAL A 1 79  ? -4.83512  8.22677   5.66186   1.000 29.16027  ? 79  VAL A N   1 
ATOM   528  C CA  . VAL A 1 79  ? -3.67915  8.81407   6.33713   1.000 27.86954  ? 79  VAL A CA  1 
ATOM   529  C C   . VAL A 1 79  ? -2.83041  7.73087   6.99061   1.000 31.11255  ? 79  VAL A C   1 
ATOM   530  O O   . VAL A 1 79  ? -1.59702  7.73261   6.88138   1.000 32.10367  ? 79  VAL A O   1 
ATOM   531  C CB  . VAL A 1 79  ? -4.13727  9.86862   7.36361   1.000 33.49486  ? 79  VAL A CB  1 
ATOM   532  C CG1 . VAL A 1 79  ? -2.98528  10.24276  8.28934   1.000 30.62342  ? 79  VAL A CG1 1 
ATOM   533  C CG2 . VAL A 1 79  ? -4.65324  11.10722  6.64961   1.000 32.04294  ? 79  VAL A CG2 1 
ATOM   534  N N   . LYS A 1 80  ? -3.47530  6.79080   7.67657   1.000 30.66389  ? 80  LYS A N   1 
ATOM   535  C CA  . LYS A 1 80  ? -2.74504  5.71574   8.33807   1.000 35.48337  ? 80  LYS A CA  1 
ATOM   536  C C   . LYS A 1 80  ? -1.97190  4.86919   7.33015   1.000 32.05506  ? 80  LYS A C   1 
ATOM   537  O O   . LYS A 1 80  ? -0.82955  4.47517   7.58485   1.000 34.87451  ? 80  LYS A O   1 
ATOM   538  C CB  . LYS A 1 80  ? -3.72874  4.86493   9.13876   1.000 34.79164  ? 80  LYS A CB  1 
ATOM   539  C CG  . LYS A 1 80  ? -3.12250  3.66821   9.84957   1.000 53.24432  ? 80  LYS A CG  1 
ATOM   540  C CD  . LYS A 1 80  ? -4.21314  2.86015   10.53984  1.000 54.17851  ? 80  LYS A CD  1 
ATOM   541  C CE  . LYS A 1 80  ? -3.71827  1.49159   10.97634  1.000 66.44126  ? 80  LYS A CE  1 
ATOM   542  N NZ  . LYS A 1 80  ? -4.33599  0.39556   10.16818  1.000 73.16263  ? 80  LYS A NZ  1 
ATOM   543  N N   . LEU A 1 81  ? -2.57995  4.58469   6.17709   1.000 32.91716  ? 81  LEU A N   1 
ATOM   544  C CA  . LEU A 1 81  ? -1.88021  3.85988   5.12097   1.000 31.85030  ? 81  LEU A CA  1 
ATOM   545  C C   . LEU A 1 81  ? -0.69960  4.65974   4.58395   1.000 31.48131  ? 81  LEU A C   1 
ATOM   546  O O   . LEU A 1 81  ? 0.37809   4.10260   4.34301   1.000 27.20252  ? 81  LEU A O   1 
ATOM   547  C CB  . LEU A 1 81  ? -2.85206  3.52806   3.99334   1.000 28.91623  ? 81  LEU A CB  1 
ATOM   548  C CG  . LEU A 1 81  ? -3.88659  2.44099   4.27868   1.000 37.60789  ? 81  LEU A CG  1 
ATOM   549  C CD1 . LEU A 1 81  ? -5.05711  2.61197   3.33842   1.000 34.54864  ? 81  LEU A CD1 1 
ATOM   550  C CD2 . LEU A 1 81  ? -3.26069  1.06291   4.11780   1.000 33.60029  ? 81  LEU A CD2 1 
ATOM   551  N N   . PHE A 1 82  ? -0.88713  5.96496   4.37255   1.000 27.63940  ? 82  PHE A N   1 
ATOM   552  C CA  . PHE A 1 82  ? 0.21318   6.79449   3.89071   1.000 30.03331  ? 82  PHE A CA  1 
ATOM   553  C C   . PHE A 1 82  ? 1.40886   6.73303   4.83427   1.000 34.18219  ? 82  PHE A C   1 
ATOM   554  O O   . PHE A 1 82  ? 2.55025   6.54912   4.39413   1.000 28.03689  ? 82  PHE A O   1 
ATOM   555  C CB  . PHE A 1 82  ? -0.23099  8.24825   3.70951   1.000 25.99806  ? 82  PHE A CB  1 
ATOM   556  C CG  . PHE A 1 82  ? 0.91440   9.17772   3.39385   1.000 27.12018  ? 82  PHE A CG  1 
ATOM   557  C CD1 . PHE A 1 82  ? 1.44714   9.22609   2.11667   1.000 27.03046  ? 82  PHE A CD1 1 
ATOM   558  C CD2 . PHE A 1 82  ? 1.49320   9.95642   4.38311   1.000 27.54421  ? 82  PHE A CD2 1 
ATOM   559  C CE1 . PHE A 1 82  ? 2.51563   10.05729  1.82252   1.000 29.88549  ? 82  PHE A CE1 1 
ATOM   560  C CE2 . PHE A 1 82  ? 2.55743   10.78686  4.09746   1.000 26.14017  ? 82  PHE A CE2 1 
ATOM   561  C CZ  . PHE A 1 82  ? 3.06911   10.84021  2.81317   1.000 28.46534  ? 82  PHE A CZ  1 
ATOM   562  N N   . LYS A 1 83  ? 1.16864   6.90187   6.13946   1.000 31.57747  ? 83  LYS A N   1 
ATOM   563  C CA  . LYS A 1 83  ? 2.27540   6.89245   7.09738   1.000 32.96175  ? 83  LYS A CA  1 
ATOM   564  C C   . LYS A 1 83  ? 3.01680   5.56123   7.07305   1.000 30.77755  ? 83  LYS A C   1 
ATOM   565  O O   . LYS A 1 83  ? 4.25166   5.52719   7.13575   1.000 32.30654  ? 83  LYS A O   1 
ATOM   566  C CB  . LYS A 1 83  ? 1.75939   7.18566   8.50885   1.000 31.72545  ? 83  LYS A CB  1 
ATOM   567  C CG  . LYS A 1 83  ? 1.21686   8.59422   8.70107   1.000 34.58904  ? 83  LYS A CG  1 
ATOM   568  C CD  . LYS A 1 83  ? 1.02883   8.94846   10.17768  1.000 43.98735  ? 83  LYS A CD  1 
ATOM   569  C CE  . LYS A 1 83  ? -0.02575  8.08790   10.83899  1.000 52.74185  ? 83  LYS A CE  1 
ATOM   570  N NZ  . LYS A 1 83  ? -0.29409  8.52923   12.24248  1.000 63.77684  ? 83  LYS A NZ  1 
ATOM   571  N N   . GLN A 1 84  ? 2.27972   4.45357   6.96509   1.000 30.58189  ? 84  GLN A N   1 
ATOM   572  C CA  . GLN A 1 84  ? 2.91170   3.13784   7.00617   1.000 34.76981  ? 84  GLN A CA  1 
ATOM   573  C C   . GLN A 1 84  ? 3.70046   2.85566   5.73503   1.000 32.35993  ? 84  GLN A C   1 
ATOM   574  O O   . GLN A 1 84  ? 4.81629   2.32488   5.79564   1.000 35.44399  ? 84  GLN A O   1 
ATOM   575  C CB  . GLN A 1 84  ? 1.85770   2.05974   7.22942   1.000 35.02152  ? 84  GLN A CB  1 
ATOM   576  C CG  . GLN A 1 84  ? 2.42042   0.65076   7.19675   1.000 55.27041  ? 84  GLN A CG  1 
ATOM   577  C CD  . GLN A 1 84  ? 1.75882   -0.24730  8.21632   1.000 60.75879  ? 84  GLN A CD  1 
ATOM   578  O OE1 . GLN A 1 84  ? 1.34661   0.21067   9.28248   1.000 76.36929  ? 84  GLN A OE1 1 
ATOM   579  N NE2 . GLN A 1 84  ? 1.64683   -1.52991  7.89586   1.000 53.80327  ? 84  GLN A NE2 1 
ATOM   580  N N   . ILE A 1 85  ? 3.13659   3.19730   4.57541   1.000 27.54805  ? 85  ILE A N   1 
ATOM   581  C CA  . ILE A 1 85  ? 3.85727   3.02806   3.31752   1.000 23.18690  ? 85  ILE A CA  1 
ATOM   582  C C   . ILE A 1 85  ? 5.07572   3.94619   3.26808   1.000 33.76187  ? 85  ILE A C   1 
ATOM   583  O O   . ILE A 1 85  ? 6.16011   3.54141   2.82983   1.000 31.75160  ? 85  ILE A O   1 
ATOM   584  C CB  . ILE A 1 85  ? 2.90336   3.26816   2.13189   1.000 26.31804  ? 85  ILE A CB  1 
ATOM   585  C CG1 . ILE A 1 85  ? 1.87288   2.13865   2.05609   1.000 25.88997  ? 85  ILE A CG1 1 
ATOM   586  C CG2 . ILE A 1 85  ? 3.68096   3.40357   0.83143   1.000 27.23773  ? 85  ILE A CG2 1 
ATOM   587  C CD1 . ILE A 1 85  ? 0.65702   2.46822   1.20751   1.000 24.52009  ? 85  ILE A CD1 1 
ATOM   588  N N   . ARG A 1 86  ? 4.92311   5.19125   3.72901   1.000 30.61698  ? 86  ARG A N   1 
ATOM   589  C CA  . ARG A 1 86  ? 6.03966   6.13592   3.72258   1.000 29.66159  ? 86  ARG A CA  1 
ATOM   590  C C   . ARG A 1 86  ? 7.17560   5.67392   4.63101   1.000 34.90324  ? 86  ARG A C   1 
ATOM   591  O O   . ARG A 1 86  ? 8.35064   5.92656   4.33565   1.000 37.79285  ? 86  ARG A O   1 
ATOM   592  C CB  . ARG A 1 86  ? 5.53608   7.51974   4.13933   1.000 33.06749  ? 86  ARG A CB  1 
ATOM   593  C CG  . ARG A 1 86  ? 6.60480   8.54774   4.42706   1.000 32.84767  ? 86  ARG A CG  1 
ATOM   594  C CD  . ARG A 1 86  ? 7.28701   9.04665   3.16154   1.000 41.96459  ? 86  ARG A CD  1 
ATOM   595  N NE  . ARG A 1 86  ? 8.22883   10.11954  3.47370   1.000 38.83027  ? 86  ARG A NE  1 
ATOM   596  C CZ  . ARG A 1 86  ? 9.43296   9.92207   3.99672   1.000 44.20460  ? 86  ARG A CZ  1 
ATOM   597  N NH1 . ARG A 1 86  ? 9.84764   8.68979   4.26507   1.000 45.56016  ? 86  ARG A NH1 1 
ATOM   598  N NH2 . ARG A 1 86  ? 10.22090  10.95348  4.25918   1.000 44.61972  ? 86  ARG A NH2 1 
ATOM   599  N N   . MET A 1 87  ? 6.84694   4.97813   5.72192   1.000 31.71225  ? 87  MET A N   1 
ATOM   600  C CA  . MET A 1 87  ? 7.85607   4.47829   6.64951   1.000 39.08501  ? 87  MET A CA  1 
ATOM   601  C C   . MET A 1 87  ? 8.76739   3.42651   6.02786   1.000 35.52930  ? 87  MET A C   1 
ATOM   602  O O   . MET A 1 87  ? 9.84890   3.17883   6.56574   1.000 42.82434  ? 87  MET A O   1 
ATOM   603  C CB  . MET A 1 87  ? 7.18497   3.88419   7.88835   1.000 42.82921  ? 87  MET A CB  1 
ATOM   604  C CG  . MET A 1 87  ? 7.11536   4.81493   9.08486   1.000 58.08250  ? 87  MET A CG  1 
ATOM   605  S SD  . MET A 1 87  ? 6.38913   3.98565   10.51633  1.000 76.85057  ? 87  MET A SD  1 
ATOM   606  C CE  . MET A 1 87  ? 7.50137   2.59319   10.70743  1.000 62.95077  ? 87  MET A CE  1 
ATOM   607  N N   . ILE A 1 88  ? 8.34112   2.78222   4.93518   1.000 39.61684  ? 88  ILE A N   1 
ATOM   608  C CA  . ILE A 1 88  ? 9.19022   1.81607   4.23463   1.000 36.11510  ? 88  ILE A CA  1 
ATOM   609  C C   . ILE A 1 88  ? 10.55665  2.41740   3.96236   1.000 43.50485  ? 88  ILE A C   1 
ATOM   610  O O   . ILE A 1 88  ? 11.59705  1.76193   4.11105   1.000 42.07355  ? 88  ILE A O   1 
ATOM   611  C CB  . ILE A 1 88  ? 8.51847   1.37083   2.92289   1.000 41.11778  ? 88  ILE A CB  1 
ATOM   612  C CG1 . ILE A 1 88  ? 7.31048   0.48397   3.19873   1.000 37.10515  ? 88  ILE A CG1 1 
ATOM   613  C CG2 . ILE A 1 88  ? 9.51314   0.65562   2.00223   1.000 36.64922  ? 88  ILE A CG2 1 
ATOM   614  C CD1 . ILE A 1 88  ? 6.46444   0.28320   1.97194   1.000 37.45684  ? 88  ILE A CD1 1 
ATOM   615  N N   . TYR A 1 89  ? 10.56561  3.67065   3.54850   1.000 35.32295  ? 89  TYR A N   1 
ATOM   616  C CA  . TYR A 1 89  ? 11.78481  4.39234   3.25112   1.000 37.51785  ? 89  TYR A CA  1 
ATOM   617  C C   . TYR A 1 89  ? 12.34858  4.92016   4.56402   1.000 43.09117  ? 89  TYR A C   1 
ATOM   618  O O   . TYR A 1 89  ? 11.64428  5.59162   5.32666   1.000 50.69877  ? 89  TYR A O   1 
ATOM   619  C CB  . TYR A 1 89  ? 11.46572  5.49533   2.24156   1.000 35.16207  ? 89  TYR A CB  1 
ATOM   620  C CG  . TYR A 1 89  ? 10.71024  4.92089   1.05276   1.000 35.20400  ? 89  TYR A CG  1 
ATOM   621  C CD1 . TYR A 1 89  ? 11.39781  4.42244   -0.05071  1.000 30.25627  ? 89  TYR A CD1 1 
ATOM   622  C CD2 . TYR A 1 89  ? 9.31332   4.80803   1.06363   1.000 32.20247  ? 89  TYR A CD2 1 
ATOM   623  C CE1 . TYR A 1 89  ? 10.72750  3.86729   -1.12122  1.000 33.23031  ? 89  TYR A CE1 1 
ATOM   624  C CE2 . TYR A 1 89  ? 8.62910   4.23594   -0.00743  1.000 29.35052  ? 89  TYR A CE2 1 
ATOM   625  C CZ  . TYR A 1 89  ? 9.34507   3.77247   -1.09693  1.000 33.41065  ? 89  TYR A CZ  1 
ATOM   626  O OH  . TYR A 1 89  ? 8.70470   3.20056   -2.16990  1.000 31.32803  ? 89  TYR A OH  1 
ATOM   627  N N   . HIS A 1 90  ? 13.59259  4.56543   4.85828   1.000 47.67665  ? 90  HIS A N   1 
ATOM   628  C CA  . HIS A 1 90  ? 14.21642  4.93143   6.12859   1.000 57.33570  ? 90  HIS A CA  1 
ATOM   629  C C   . HIS A 1 90  ? 14.88358  6.28635   5.94033   1.000 59.37706  ? 90  HIS A C   1 
ATOM   630  O O   . HIS A 1 90  ? 16.06157  6.38445   5.59224   1.000 64.47332  ? 90  HIS A O   1 
ATOM   631  C CB  . HIS A 1 90  ? 15.19828  3.85543   6.57232   1.000 56.31838  ? 90  HIS A CB  1 
ATOM   632  C CG  . HIS A 1 90  ? 14.54057  2.56914   6.96903   1.000 62.70054  ? 90  HIS A CG  1 
ATOM   633  N ND1 . HIS A 1 90  ? 13.23576  2.50630   7.40964   1.000 61.85446  ? 90  HIS A ND1 1 
ATOM   634  C CD2 . HIS A 1 90  ? 15.00491  1.29711   6.98906   1.000 68.29582  ? 90  HIS A CD2 1 
ATOM   635  C CE1 . HIS A 1 90  ? 12.92510  1.25284   7.68762   1.000 58.52248  ? 90  HIS A CE1 1 
ATOM   636  N NE2 . HIS A 1 90  ? 13.98089  0.49861   7.44030   1.000 66.51995  ? 90  HIS A NE2 1 
ATOM   637  N N   . THR A 1 91  ? 14.11290  7.34678   6.15956   1.000 51.81708  ? 91  THR A N   1 
ATOM   638  C CA  . THR A 1 91  ? 14.57149  8.70658   5.91446   1.000 54.82781  ? 91  THR A CA  1 
ATOM   639  C C   . THR A 1 91  ? 14.93591  9.38097   7.22790   1.000 56.00701  ? 91  THR A C   1 
ATOM   640  O O   . THR A 1 91  ? 14.18742  9.29201   8.20724   1.000 58.55247  ? 91  THR A O   1 
ATOM   641  C CB  . THR A 1 91  ? 13.50133  9.52768   5.19181   1.000 54.57418  ? 91  THR A CB  1 
ATOM   642  O OG1 . THR A 1 91  ? 12.29782  9.55042   5.97295   1.000 52.26409  ? 91  THR A OG1 1 
ATOM   643  C CG2 . THR A 1 91  ? 13.20491  8.92566   3.83722   1.000 48.66069  ? 91  THR A CG2 1 
ATOM   644  N N   . ARG A 1 92  ? 16.08862  10.04809  7.24382   1.000 57.48087  ? 92  ARG A N   1 
ATOM   645  C CA  . ARG A 1 92  ? 16.43641  10.91516  8.36007   1.000 66.29935  ? 92  ARG A CA  1 
ATOM   646  C C   . ARG A 1 92  ? 15.74807  12.27183  8.27391   1.000 65.52962  ? 92  ARG A C   1 
ATOM   647  O O   . ARG A 1 92  ? 15.57940  12.93012  9.30568   1.000 69.38317  ? 92  ARG A O   1 
ATOM   648  C CB  . ARG A 1 92  ? 17.95263  11.10127  8.42863   1.000 69.18443  ? 92  ARG A CB  1 
ATOM   649  C CG  . ARG A 1 92  ? 18.66413  10.85272  7.10966   1.000 75.31184  ? 92  ARG A CG  1 
ATOM   650  C CD  . ARG A 1 92  ? 20.16659  10.99435  7.26737   1.000 91.46130  ? 92  ARG A CD  1 
ATOM   651  N NE  . ARG A 1 92  ? 20.90450  10.25213  6.24947   1.000 98.65312  ? 92  ARG A NE  1 
ATOM   652  C CZ  . ARG A 1 92  ? 22.22781  10.27626  6.12278   1.000 105.90279 ? 92  ARG A CZ  1 
ATOM   653  N NH1 . ARG A 1 92  ? 22.96223  11.01291  6.94614   1.000 107.04645 ? 92  ARG A NH1 1 
ATOM   654  N NH2 . ARG A 1 92  ? 22.81819  9.56676   5.17073   1.000 106.57615 ? 92  ARG A NH2 1 
ATOM   655  N N   . SER A 1 93  ? 15.33346  12.69076  7.07111   1.000 65.58353  ? 93  SER A N   1 
ATOM   656  C CA  . SER A 1 93  ? 14.67012  13.95222  6.77525   1.000 56.91071  ? 93  SER A CA  1 
ATOM   657  C C   . SER A 1 93  ? 13.18456  13.72574  6.50370   1.000 50.21318  ? 93  SER A C   1 
ATOM   658  O O   . SER A 1 93  ? 12.78217  12.63392  6.09212   1.000 49.19949  ? 93  SER A O   1 
ATOM   659  C CB  . SER A 1 93  ? 15.31658  14.62931  5.56133   1.000 53.02467  ? 93  SER A CB  1 
ATOM   660  O OG  . SER A 1 93  ? 14.58897  15.77287  5.13885   1.000 70.01333  ? 93  SER A OG  1 
ATOM   661  N N   . PRO A 1 94  ? 12.33540  14.73174  6.73588   1.000 55.04355  ? 94  PRO A N   1 
ATOM   662  C CA  . PRO A 1 94  ? 10.90841  14.55423  6.41993   1.000 50.42353  ? 94  PRO A CA  1 
ATOM   663  C C   . PRO A 1 94  ? 10.63199  14.38087  4.93394   1.000 51.09647  ? 94  PRO A C   1 
ATOM   664  O O   . PRO A 1 94  ? 9.67414   13.68002  4.57664   1.000 53.08138  ? 94  PRO A O   1 
ATOM   665  C CB  . PRO A 1 94  ? 10.25971  15.83101  6.97639   1.000 50.73983  ? 94  PRO A CB  1 
ATOM   666  C CG  . PRO A 1 94  ? 11.37605  16.81540  7.10558   1.000 49.22611  ? 94  PRO A CG  1 
ATOM   667  C CD  . PRO A 1 94  ? 12.59032  15.99897  7.44297   1.000 58.72445  ? 94  PRO A CD  1 
ATOM   668  N N   . LEU A 1 95  ? 11.43909  14.98834  4.06359   1.000 38.48066  ? 95  LEU A N   1 
ATOM   669  C CA  . LEU A 1 95  ? 11.25343  14.88718  2.62199   1.000 33.84890  ? 95  LEU A CA  1 
ATOM   670  C C   . LEU A 1 95  ? 11.95800  13.65490  2.06654   1.000 40.33951  ? 95  LEU A C   1 
ATOM   671  O O   . LEU A 1 95  ? 13.11402  13.38818  2.40365   1.000 38.46093  ? 95  LEU A O   1 
ATOM   672  C CB  . LEU A 1 95  ? 11.79868  16.13612  1.93158   1.000 37.04854  ? 95  LEU A CB  1 
ATOM   673  C CG  . LEU A 1 95  ? 10.80790  17.15667  1.38648   1.000 43.66607  ? 95  LEU A CG  1 
ATOM   674  C CD1 . LEU A 1 95  ? 9.77986   17.48411  2.43524   1.000 48.64926  ? 95  LEU A CD1 1 
ATOM   675  C CD2 . LEU A 1 95  ? 11.54681  18.39878  0.94179   1.000 48.76781  ? 95  LEU A CD2 1 
ATOM   676  N N   . LEU A 1 96  ? 11.26575  12.92095  1.19617   1.000 35.50180  ? 96  LEU A N   1 
ATOM   677  C CA  . LEU A 1 96  ? 11.88018  11.82361  0.46338   1.000 35.71299  ? 96  LEU A CA  1 
ATOM   678  C C   . LEU A 1 96  ? 12.78542  12.34908  -0.64120  1.000 32.32384  ? 96  LEU A C   1 
ATOM   679  O O   . LEU A 1 96  ? 12.50528  13.37413  -1.26483  1.000 38.82209  ? 96  LEU A O   1 
ATOM   680  C CB  . LEU A 1 96  ? 10.81319  10.93058  -0.16794  1.000 35.05495  ? 96  LEU A CB  1 
ATOM   681  C CG  . LEU A 1 96  ? 10.34537  9.66697   0.53527   1.000 42.38296  ? 96  LEU A CG  1 
ATOM   682  C CD1 . LEU A 1 96  ? 9.26959   9.01295   -0.31435  1.000 43.96080  ? 96  LEU A CD1 1 
ATOM   683  C CD2 . LEU A 1 96  ? 11.50884  8.71604   0.72710   1.000 42.61017  ? 96  LEU A CD2 1 
ATOM   684  N N   . SER A 1 97  ? 13.86873  11.61994  -0.90035  1.000 33.58310  ? 97  SER A N   1 
ATOM   685  C CA  . SER A 1 97  ? 14.75028  11.91074  -2.02207  1.000 33.71494  ? 97  SER A CA  1 
ATOM   686  C C   . SER A 1 97  ? 14.98127  10.63596  -2.81438  1.000 32.54879  ? 97  SER A C   1 
ATOM   687  O O   . SER A 1 97  ? 14.72030  9.53067   -2.33250  1.000 33.12015  ? 97  SER A O   1 
ATOM   688  C CB  . SER A 1 97  ? 16.09672  12.48793  -1.56480  1.000 37.51609  ? 97  SER A CB  1 
ATOM   689  O OG  . SER A 1 97  ? 16.89570  11.48133  -0.96734  1.000 39.68111  ? 97  SER A OG  1 
ATOM   690  N N   . VAL A 1 98  ? 15.49087  10.79866  -4.03998  1.000 37.09512  ? 98  VAL A N   1 
ATOM   691  C CA  . VAL A 1 98  ? 15.76471  9.63767   -4.88754  1.000 34.73825  ? 98  VAL A CA  1 
ATOM   692  C C   . VAL A 1 98  ? 16.75426  8.69091   -4.21872  1.000 37.42903  ? 98  VAL A C   1 
ATOM   693  O O   . VAL A 1 98  ? 16.74895  7.48478   -4.49246  1.000 38.18736  ? 98  VAL A O   1 
ATOM   694  C CB  . VAL A 1 98  ? 16.27039  10.08075  -6.27513  1.000 39.61804  ? 98  VAL A CB  1 
ATOM   695  C CG1 . VAL A 1 98  ? 15.19947  10.88568  -7.00314  1.000 30.67807  ? 98  VAL A CG1 1 
ATOM   696  C CG2 . VAL A 1 98  ? 17.55619  10.88547  -6.14069  1.000 37.68962  ? 98  VAL A CG2 1 
ATOM   697  N N   . HIS A 1 99  ? 17.60920  9.20247   -3.32869  1.000 36.98335  ? 99  HIS A N   1 
ATOM   698  C CA  . HIS A 1 99  ? 18.55992  8.31320   -2.66878  1.000 37.37440  ? 99  HIS A CA  1 
ATOM   699  C C   . HIS A 1 99  ? 17.87210  7.39219   -1.67014  1.000 36.68459  ? 99  HIS A C   1 
ATOM   700  O O   . HIS A 1 99  ? 18.34200  6.27512   -1.43692  1.000 35.96768  ? 99  HIS A O   1 
ATOM   701  C CB  . HIS A 1 99  ? 19.66705  9.10995   -1.97510  1.000 39.26044  ? 99  HIS A CB  1 
ATOM   702  C CG  . HIS A 1 99  ? 20.77953  8.25097   -1.45144  1.000 46.28263  ? 99  HIS A CG  1 
ATOM   703  N ND1 . HIS A 1 99  ? 20.79502  7.75420   -0.16587  1.000 42.14121  ? 99  HIS A ND1 1 
ATOM   704  C CD2 . HIS A 1 99  ? 21.89330  7.76837   -2.05350  1.000 43.44118  ? 99  HIS A CD2 1 
ATOM   705  C CE1 . HIS A 1 99  ? 21.87919  7.01940   0.00880   1.000 43.51229  ? 99  HIS A CE1 1 
ATOM   706  N NE2 . HIS A 1 99  ? 22.56359  7.01188   -1.12191  1.000 45.25386  ? 99  HIS A NE2 1 
ATOM   707  N N   . ASP A 1 100 ? 16.77150  7.83376   -1.06100  1.000 34.10031  ? 100 ASP A N   1 
ATOM   708  C CA  . ASP A 1 100 ? 16.02011  6.93325   -0.19886  1.000 34.94817  ? 100 ASP A CA  1 
ATOM   709  C C   . ASP A 1 100 ? 15.36685  5.80839   -0.99347  1.000 30.91682  ? 100 ASP A C   1 
ATOM   710  O O   . ASP A 1 100 ? 15.06129  4.75404   -0.42702  1.000 30.38808  ? 100 ASP A O   1 
ATOM   711  C CB  . ASP A 1 100 ? 14.95186  7.70974   0.57178   1.000 36.69176  ? 100 ASP A CB  1 
ATOM   712  C CG  . ASP A 1 100 ? 15.53145  8.83502   1.40400   1.000 41.04548  ? 100 ASP A CG  1 
ATOM   713  O OD1 . ASP A 1 100 ? 16.50892  8.58813   2.14375   1.000 39.20773  ? 100 ASP A OD1 1 
ATOM   714  O OD2 . ASP A 1 100 ? 15.00156  9.96613   1.31678   1.000 37.51318  ? 100 ASP A OD2 1 
ATOM   715  N N   . VAL A 1 101 ? 15.13764  6.01692   -2.28720  1.000 33.84472  ? 101 VAL A N   1 
ATOM   716  C CA  . VAL A 1 101 ? 14.49050  4.99306   -3.09612  1.000 31.27391  ? 101 VAL A CA  1 
ATOM   717  C C   . VAL A 1 101 ? 15.52110  3.99632   -3.61568  1.000 34.88971  ? 101 VAL A C   1 
ATOM   718  O O   . VAL A 1 101 ? 15.29077  2.78313   -3.59788  1.000 30.27018  ? 101 VAL A O   1 
ATOM   719  C CB  . VAL A 1 101 ? 13.70346  5.65817   -4.24117  1.000 31.69521  ? 101 VAL A CB  1 
ATOM   720  C CG1 . VAL A 1 101 ? 13.06708  4.61525   -5.12878  1.000 35.38432  ? 101 VAL A CG1 1 
ATOM   721  C CG2 . VAL A 1 101 ? 12.65704  6.61433   -3.68085  1.000 31.92228  ? 101 VAL A CG2 1 
ATOM   722  N N   . ALA A 1 102 ? 16.67206  4.49482   -4.07042  1.000 33.45610  ? 102 ALA A N   1 
ATOM   723  C CA  . ALA A 1 102 ? 17.74076  3.67480   -4.63993  1.000 39.28379  ? 102 ALA A CA  1 
ATOM   724  C C   . ALA A 1 102 ? 19.05493  4.00218   -3.93524  1.000 43.49261  ? 102 ALA A C   1 
ATOM   725  O O   . ALA A 1 102 ? 19.96015  4.61353   -4.52195  1.000 37.18377  ? 102 ALA A O   1 
ATOM   726  C CB  . ALA A 1 102 ? 17.85496  3.90653   -6.14778  1.000 38.99644  ? 102 ALA A CB  1 
ATOM   727  N N   . PRO A 1 103 ? 19.19144  3.61055   -2.66848  1.000 37.36230  ? 103 PRO A N   1 
ATOM   728  C CA  . PRO A 1 103 ? 20.40017  3.96917   -1.91861  1.000 37.65206  ? 103 PRO A CA  1 
ATOM   729  C C   . PRO A 1 103 ? 21.63664  3.33104   -2.53407  1.000 36.79943  ? 103 PRO A C   1 
ATOM   730  O O   . PRO A 1 103 ? 21.62762  2.16711   -2.94185  1.000 40.19592  ? 103 PRO A O   1 
ATOM   731  C CB  . PRO A 1 103 ? 20.11714  3.43128   -0.51124  1.000 38.70850  ? 103 PRO A CB  1 
ATOM   732  C CG  . PRO A 1 103 ? 19.12157  2.33210   -0.71990  1.000 38.02617  ? 103 PRO A CG  1 
ATOM   733  C CD  . PRO A 1 103 ? 18.27618  2.76277   -1.88178  1.000 36.43769  ? 103 PRO A CD  1 
ATOM   734  N N   . GLY A 1 104 ? 22.70176  4.11823   -2.62094  1.000 37.73107  ? 104 GLY A N   1 
ATOM   735  C CA  . GLY A 1 104 ? 23.91839  3.66053   -3.25205  1.000 43.96588  ? 104 GLY A CA  1 
ATOM   736  C C   . GLY A 1 104 ? 23.91542  3.71106   -4.76329  1.000 45.98976  ? 104 GLY A C   1 
ATOM   737  O O   . GLY A 1 104 ? 24.94512  3.39568   -5.37428  1.000 37.09544  ? 104 GLY A O   1 
ATOM   738  N N   . LEU A 1 105 ? 22.80475  4.11495   -5.38640  1.000 37.89749  ? 105 LEU A N   1 
ATOM   739  C CA  . LEU A 1 105 ? 22.67401  4.13251   -6.83836  1.000 35.72979  ? 105 LEU A CA  1 
ATOM   740  C C   . LEU A 1 105 ? 22.31166  5.50656   -7.37795  1.000 36.53845  ? 105 LEU A C   1 
ATOM   741  O O   . LEU A 1 105 ? 22.97049  5.99954   -8.30172  1.000 37.33654  ? 105 LEU A O   1 
ATOM   742  C CB  . LEU A 1 105 ? 21.62320  3.09850   -7.28949  1.000 37.99502  ? 105 LEU A CB  1 
ATOM   743  C CG  . LEU A 1 105 ? 21.92094  1.61459   -7.06593  1.000 35.08581  ? 105 LEU A CG  1 
ATOM   744  C CD1 . LEU A 1 105 ? 20.66953  0.78048   -7.29760  1.000 35.85851  ? 105 LEU A CD1 1 
ATOM   745  C CD2 . LEU A 1 105 ? 23.04880  1.13591   -7.98079  1.000 38.49645  ? 105 LEU A CD2 1 
ATOM   746  N N   . TRP A 1 106 ? 21.27598  6.14555   -6.84035  1.000 39.00385  ? 106 TRP A N   1 
ATOM   747  C CA  . TRP A 1 106 ? 20.85533  7.46426   -7.29968  1.000 34.54413  ? 106 TRP A CA  1 
ATOM   748  C C   . TRP A 1 106 ? 21.15114  8.46652   -6.19251  1.000 42.17429  ? 106 TRP A C   1 
ATOM   749  O O   . TRP A 1 106 ? 20.49305  8.45757   -5.14831  1.000 38.82971  ? 106 TRP A O   1 
ATOM   750  C CB  . TRP A 1 106 ? 19.37393  7.47542   -7.67725  1.000 35.82285  ? 106 TRP A CB  1 
ATOM   751  C CG  . TRP A 1 106 ? 18.98376  8.65211   -8.53679  1.000 38.09474  ? 106 TRP A CG  1 
ATOM   752  C CD1 . TRP A 1 106 ? 19.74080  9.75926   -8.80606  1.000 39.52865  ? 106 TRP A CD1 1 
ATOM   753  C CD2 . TRP A 1 106 ? 17.74937  8.82911   -9.24875  1.000 37.91066  ? 106 TRP A CD2 1 
ATOM   754  N NE1 . TRP A 1 106 ? 19.05348  10.61369  -9.63511  1.000 44.48150  ? 106 TRP A NE1 1 
ATOM   755  C CE2 . TRP A 1 106 ? 17.82895  10.06689  -9.92210  1.000 42.76993  ? 106 TRP A CE2 1 
ATOM   756  C CE3 . TRP A 1 106 ? 16.58650  8.06263   -9.38140  1.000 38.76200  ? 106 TRP A CE3 1 
ATOM   757  C CZ2 . TRP A 1 106 ? 16.78978  10.55551  -10.71342 1.000 39.84483  ? 106 TRP A CZ2 1 
ATOM   758  C CZ3 . TRP A 1 106 ? 15.55246  8.55124   -10.16666 1.000 33.44723  ? 106 TRP A CZ3 1 
ATOM   759  C CH2 . TRP A 1 106 ? 15.66261  9.78522   -10.82225 1.000 36.91730  ? 106 TRP A CH2 1 
ATOM   760  N N   . PHE A 1 107 ? 22.14130  9.33000   -6.42212  1.000 43.77999  ? 107 PHE A N   1 
ATOM   761  C CA  . PHE A 1 107 ? 22.49961  10.33674  -5.43235  1.000 44.38621  ? 107 PHE A CA  1 
ATOM   762  C C   . PHE A 1 107 ? 21.88026  11.68132  -5.79416  1.000 53.83961  ? 107 PHE A C   1 
ATOM   763  O O   . PHE A 1 107 ? 21.84186  12.04975  -6.97442  1.000 48.51301  ? 107 PHE A O   1 
ATOM   764  C CB  . PHE A 1 107 ? 24.01971  10.47596  -5.33468  1.000 47.67254  ? 107 PHE A CB  1 
ATOM   765  C CG  . PHE A 1 107 ? 24.72587  9.16371   -5.13280  1.000 43.43038  ? 107 PHE A CG  1 
ATOM   766  C CD1 . PHE A 1 107 ? 24.83718  8.61076   -3.86916  1.000 40.94585  ? 107 PHE A CD1 1 
ATOM   767  C CD2 . PHE A 1 107 ? 25.25140  8.46999   -6.21145  1.000 46.98915  ? 107 PHE A CD2 1 
ATOM   768  C CE1 . PHE A 1 107 ? 25.47246  7.39386   -3.67990  1.000 45.36083  ? 107 PHE A CE1 1 
ATOM   769  C CE2 . PHE A 1 107 ? 25.88917  7.25403   -6.03292  1.000 45.71951  ? 107 PHE A CE2 1 
ATOM   770  C CZ  . PHE A 1 107 ? 25.99714  6.71263   -4.76458  1.000 48.63535  ? 107 PHE A CZ  1 
ATOM   771  N N   . PRO A 1 108 ? 21.36498  12.41603  -4.80947  1.000 54.51218  ? 108 PRO A N   1 
ATOM   772  C CA  . PRO A 1 108 ? 20.73003  13.70299  -5.11158  1.000 61.71900  ? 108 PRO A CA  1 
ATOM   773  C C   . PRO A 1 108 ? 21.71899  14.66735  -5.74872  1.000 66.04744  ? 108 PRO A C   1 
ATOM   774  O O   . PRO A 1 108 ? 22.91091  14.66682  -5.43189  1.000 68.44100  ? 108 PRO A O   1 
ATOM   775  C CB  . PRO A 1 108 ? 20.26085  14.19989  -3.73854  1.000 58.01813  ? 108 PRO A CB  1 
ATOM   776  C CG  . PRO A 1 108 ? 20.14084  12.96310  -2.91018  1.000 58.80566  ? 108 PRO A CG  1 
ATOM   777  C CD  . PRO A 1 108 ? 21.25541  12.06914  -3.38329  1.000 59.46237  ? 108 PRO A CD  1 
ATOM   778  N N   . ASN A 1 109 ? 21.20316  15.48517  -6.66997  1.000 72.16427  ? 109 ASN A N   1 
ATOM   779  C CA  . ASN A 1 109 ? 22.01525  16.42618  -7.44406  1.000 76.68455  ? 109 ASN A CA  1 
ATOM   780  C C   . ASN A 1 109 ? 23.14878  15.70141  -8.16946  1.000 78.83535  ? 109 ASN A C   1 
ATOM   781  O O   . ASN A 1 109 ? 24.29085  16.16462  -8.21325  1.000 84.68288  ? 109 ASN A O   1 
ATOM   782  C CB  . ASN A 1 109 ? 22.55159  17.55074  -6.55506  1.000 80.37432  ? 109 ASN A CB  1 
ATOM   783  C CG  . ASN A 1 109 ? 21.44253  18.33329  -5.87311  1.000 80.49435  ? 109 ASN A CG  1 
ATOM   784  O OD1 . ASN A 1 109 ? 20.32187  18.41606  -6.37767  1.000 78.55227  ? 109 ASN A OD1 1 
ATOM   785  N ND2 . ASN A 1 109 ? 21.75157  18.91204  -4.71933  1.000 80.49311  ? 109 ASN A ND2 1 
ATOM   786  N N   . SER A 1 110 ? 22.82914  14.53987  -8.72469  1.000 69.24703  ? 110 SER A N   1 
ATOM   787  C CA  . SER A 1 110 ? 23.73823  13.74098  -9.52958  1.000 63.53424  ? 110 SER A CA  1 
ATOM   788  C C   . SER A 1 110 ? 22.93269  13.10824  -10.65265 1.000 62.50497  ? 110 SER A C   1 
ATOM   789  O O   . SER A 1 110 ? 21.70589  12.99380  -10.55445 1.000 66.03317  ? 110 SER A O   1 
ATOM   790  C CB  . SER A 1 110 ? 24.43262  12.65332  -8.69750  1.000 61.83664  ? 110 SER A CB  1 
ATOM   791  O OG  . SER A 1 110 ? 25.14338  13.21704  -7.60716  1.000 73.71700  ? 110 SER A OG  1 
ATOM   792  N N   . PRO A 1 111 ? 23.58750  12.70810  -11.74085 1.000 59.28729  ? 111 PRO A N   1 
ATOM   793  C CA  . PRO A 1 111 ? 22.85814  12.04139  -12.81526 1.000 59.22275  ? 111 PRO A CA  1 
ATOM   794  C C   . PRO A 1 111 ? 22.24836  10.74707  -12.32395 1.000 52.37908  ? 111 PRO A C   1 
ATOM   795  O O   . PRO A 1 111 ? 22.81112  10.06409  -11.44532 1.000 49.96245  ? 111 PRO A O   1 
ATOM   796  C CB  . PRO A 1 111 ? 23.94271  11.78932  -13.87350 1.000 59.58815  ? 111 PRO A CB  1 
ATOM   797  C CG  . PRO A 1 111 ? 24.97707  12.82591  -13.60218 1.000 67.04035  ? 111 PRO A CG  1 
ATOM   798  C CD  . PRO A 1 111 ? 24.98426  12.99156  -12.11307 1.000 70.07786  ? 111 PRO A CD  1 
ATOM   799  N N   . PRO A 1 112 ? 21.08246  10.37208  -12.84893 1.000 52.00774  ? 112 PRO A N   1 
ATOM   800  C CA  . PRO A 1 112 ? 20.49651  9.08940   -12.47442 1.000 48.41657  ? 112 PRO A CA  1 
ATOM   801  C C   . PRO A 1 112 ? 21.38210  7.95231   -12.93289 1.000 44.09681  ? 112 PRO A C   1 
ATOM   802  O O   . PRO A 1 112 ? 22.08428  8.06123   -13.95728 1.000 44.91212  ? 112 PRO A O   1 
ATOM   803  C CB  . PRO A 1 112 ? 19.14977  9.08630   -13.21434 1.000 41.84281  ? 112 PRO A CB  1 
ATOM   804  C CG  . PRO A 1 112 ? 18.88980  10.51951  -13.57735 1.000 52.27859  ? 112 PRO A CG  1 
ATOM   805  C CD  . PRO A 1 112 ? 20.23657  11.12308  -13.78998 1.000 49.30455  ? 112 PRO A CD  1 
ATOM   806  N N   . PRO A 1 113 ? 21.39323  6.83785   -12.20414 1.000 39.93418  ? 113 PRO A N   1 
ATOM   807  C CA  . PRO A 1 113 ? 22.16962  5.67711   -12.65245 1.000 38.98211  ? 113 PRO A CA  1 
ATOM   808  C C   . PRO A 1 113 ? 21.56633  5.06399   -13.90485 1.000 41.22886  ? 113 PRO A C   1 
ATOM   809  O O   . PRO A 1 113 ? 20.35825  5.13871   -14.14376 1.000 37.34907  ? 113 PRO A O   1 
ATOM   810  C CB  . PRO A 1 113 ? 22.08433  4.71213   -11.46585 1.000 41.28345  ? 113 PRO A CB  1 
ATOM   811  C CG  . PRO A 1 113 ? 20.80416  5.08539   -10.78923 1.000 39.40992  ? 113 PRO A CG  1 
ATOM   812  C CD  . PRO A 1 113 ? 20.68736  6.57618   -10.93931 1.000 39.44157  ? 113 PRO A CD  1 
ATOM   813  N N   . LEU A 1 114 ? 22.43266  4.44707   -14.71094 1.000 37.27488  ? 114 LEU A N   1 
ATOM   814  C CA  . LEU A 1 114 ? 21.97978  3.86437   -15.97060 1.000 44.27730  ? 114 LEU A CA  1 
ATOM   815  C C   . LEU A 1 114 ? 20.94085  2.77338   -15.74018 1.000 42.67248  ? 114 LEU A C   1 
ATOM   816  O O   . LEU A 1 114 ? 20.01120  2.61923   -16.53904 1.000 42.52695  ? 114 LEU A O   1 
ATOM   817  C CB  . LEU A 1 114 ? 23.16875  3.30796   -16.75893 1.000 47.12373  ? 114 LEU A CB  1 
ATOM   818  C CG  . LEU A 1 114 ? 22.80967  2.48676   -18.00636 1.000 47.13869  ? 114 LEU A CG  1 
ATOM   819  C CD1 . LEU A 1 114 ? 22.02800  3.33094   -19.01290 1.000 50.47818  ? 114 LEU A CD1 1 
ATOM   820  C CD2 . LEU A 1 114 ? 24.05228  1.88448   -18.65999 1.000 44.93359  ? 114 LEU A CD2 1 
ATOM   821  N N   . ILE A 1 115 ? 21.07206  2.01241   -14.64945 1.000 36.50148  ? 115 ILE A N   1 
ATOM   822  C CA  . ILE A 1 115 ? 20.16831  0.88758   -14.42824 1.000 41.57147  ? 115 ILE A CA  1 
ATOM   823  C C   . ILE A 1 115 ? 18.72706  1.34137   -14.19176 1.000 41.35091  ? 115 ILE A C   1 
ATOM   824  O O   . ILE A 1 115 ? 17.79795  0.53865   -14.32803 1.000 39.97531  ? 115 ILE A O   1 
ATOM   825  C CB  . ILE A 1 115 ? 20.67245  0.01209   -13.26496 1.000 38.82169  ? 115 ILE A CB  1 
ATOM   826  C CG1 . ILE A 1 115 ? 20.00371  -1.36416  -13.31211 1.000 37.20196  ? 115 ILE A CG1 1 
ATOM   827  C CG2 . ILE A 1 115 ? 20.44207  0.68849   -11.92532 1.000 32.45775  ? 115 ILE A CG2 1 
ATOM   828  C CD1 . ILE A 1 115 ? 20.55439  -2.34487  -12.31130 1.000 40.16161  ? 115 ILE A CD1 1 
ATOM   829  N N   . LEU A 1 116 ? 18.51122  2.61323   -13.86433 1.000 36.39609  ? 116 LEU A N   1 
ATOM   830  C CA  . LEU A 1 116 ? 17.16770  3.14140   -13.67293 1.000 39.44077  ? 116 LEU A CA  1 
ATOM   831  C C   . LEU A 1 116 ? 16.65248  3.90884   -14.88491 1.000 44.12445  ? 116 LEU A C   1 
ATOM   832  O O   . LEU A 1 116 ? 15.59468  4.54371   -14.79704 1.000 41.46538  ? 116 LEU A O   1 
ATOM   833  C CB  . LEU A 1 116 ? 17.12995  4.03125   -12.43295 1.000 30.53553  ? 116 LEU A CB  1 
ATOM   834  C CG  . LEU A 1 116 ? 17.39969  3.29433   -11.12166 1.000 35.63881  ? 116 LEU A CG  1 
ATOM   835  C CD1 . LEU A 1 116 ? 17.38454  4.26574   -9.95095  1.000 38.24056  ? 116 LEU A CD1 1 
ATOM   836  C CD2 . LEU A 1 116 ? 16.38394  2.18541   -10.91989 1.000 32.60859  ? 116 LEU A CD2 1 
ATOM   837  N N   . ARG A 1 117 ? 17.36410  3.85349   -16.01137 1.000 42.35747  ? 117 ARG A N   1 
ATOM   838  C CA  . ARG A 1 117 ? 16.92570  4.54718   -17.21638 1.000 43.39635  ? 117 ARG A CA  1 
ATOM   839  C C   . ARG A 1 117 ? 15.53352  4.08168   -17.62246 1.000 40.47125  ? 117 ARG A C   1 
ATOM   840  O O   . ARG A 1 117 ? 15.26213  2.87972   -17.69456 1.000 42.38567  ? 117 ARG A O   1 
ATOM   841  C CB  . ARG A 1 117 ? 17.91651  4.30046   -18.35387 1.000 48.13955  ? 117 ARG A CB  1 
ATOM   842  C CG  . ARG A 1 117 ? 17.73533  5.20842   -19.56032 1.000 52.27503  ? 117 ARG A CG  1 
ATOM   843  C CD  . ARG A 1 117 ? 18.02731  6.65502   -19.20300 1.000 63.88267  ? 117 ARG A CD  1 
ATOM   844  N NE  . ARG A 1 117 ? 19.25320  6.78115   -18.41708 1.000 79.90945  ? 117 ARG A NE  1 
ATOM   845  C CZ  . ARG A 1 117 ? 20.44143  7.10154   -18.92199 1.000 85.83916  ? 117 ARG A CZ  1 
ATOM   846  N NH1 . ARG A 1 117 ? 20.57458  7.33888   -20.22142 1.000 79.94685  ? 117 ARG A NH1 1 
ATOM   847  N NH2 . ARG A 1 117 ? 21.49839  7.19004   -18.12465 1.000 66.38920  ? 117 ARG A NH2 1 
ATOM   848  N N   . GLY A 1 118 ? 14.65069  5.03765   -17.88677 1.000 41.48366  ? 118 GLY A N   1 
ATOM   849  C CA  . GLY A 1 118 ? 13.27058  4.72775   -18.18254 1.000 43.69079  ? 118 GLY A CA  1 
ATOM   850  C C   . GLY A 1 118 ? 12.36466  4.68000   -16.97371 1.000 44.59692  ? 118 GLY A C   1 
ATOM   851  O O   . GLY A 1 118 ? 11.15908  4.45689   -17.13281 1.000 43.74770  ? 118 GLY A O   1 
ATOM   852  N N   . HIS A 1 119 ? 12.90480  4.87667   -15.77203 1.000 40.16428  ? 119 HIS A N   1 
ATOM   853  C CA  . HIS A 1 119 ? 12.10777  4.92041   -14.55513 1.000 38.95970  ? 119 HIS A CA  1 
ATOM   854  C C   . HIS A 1 119 ? 12.22945  6.24531   -13.81689 1.000 39.94976  ? 119 HIS A C   1 
ATOM   855  O O   . HIS A 1 119 ? 11.62200  6.40169   -12.74838 1.000 35.84603  ? 119 HIS A O   1 
ATOM   856  C CB  . HIS A 1 119 ? 12.50673  3.77307   -13.62018 1.000 33.33436  ? 119 HIS A CB  1 
ATOM   857  C CG  . HIS A 1 119 ? 12.32413  2.41621   -14.22366 1.000 39.63474  ? 119 HIS A CG  1 
ATOM   858  N ND1 . HIS A 1 119 ? 11.08876  1.92412   -14.58753 1.000 35.35745  ? 119 HIS A ND1 1 
ATOM   859  C CD2 . HIS A 1 119 ? 13.21974  1.44684   -14.52900 1.000 35.42384  ? 119 HIS A CD2 1 
ATOM   860  C CE1 . HIS A 1 119 ? 11.23035  0.71399   -15.09563 1.000 35.92831  ? 119 HIS A CE1 1 
ATOM   861  N NE2 . HIS A 1 119 ? 12.51348  0.39773   -15.06723 1.000 40.98743  ? 119 HIS A NE2 1 
ATOM   862  N N   . GLU A 1 120 ? 12.98057  7.20559   -14.36383 1.000 34.09449  ? 120 GLU A N   1 
ATOM   863  C CA  . GLU A 1 120 ? 13.25689  8.44382   -13.64547 1.000 38.93649  ? 120 GLU A CA  1 
ATOM   864  C C   . GLU A 1 120 ? 11.97585  9.21905   -13.36185 1.000 33.92582  ? 120 GLU A C   1 
ATOM   865  O O   . GLU A 1 120 ? 11.73994  9.65464   -12.22992 1.000 30.45453  ? 120 GLU A O   1 
ATOM   866  C CB  . GLU A 1 120 ? 14.24039  9.30910   -14.44089 1.000 38.71463  ? 120 GLU A CB  1 
ATOM   867  C CG  . GLU A 1 120 ? 15.59052  8.65990   -14.68929 1.000 43.78001  ? 120 GLU A CG  1 
ATOM   868  C CD  . GLU A 1 120 ? 15.64736  7.92005   -16.01023 1.000 53.29158  ? 120 GLU A CD  1 
ATOM   869  O OE1 . GLU A 1 120 ? 16.76114  7.78190   -16.55611 1.000 49.98258  ? 120 GLU A OE1 1 
ATOM   870  O OE2 . GLU A 1 120 ? 14.58429  7.48144   -16.50820 1.000 43.74317  ? 120 GLU A OE2 1 
ATOM   871  N N   . ALA A 1 121 ? 11.14135  9.41409   -14.38379 1.000 29.86599  ? 121 ALA A N   1 
ATOM   872  C CA  . ALA A 1 121 ? 9.92568   10.19748  -14.19047 1.000 36.39065  ? 121 ALA A CA  1 
ATOM   873  C C   . ALA A 1 121 ? 8.96263   9.49239   -13.24599 1.000 32.79457  ? 121 ALA A C   1 
ATOM   874  O O   . ALA A 1 121 ? 8.31321   10.14029  -12.41617 1.000 34.29986  ? 121 ALA A O   1 
ATOM   875  C CB  . ALA A 1 121 ? 9.25788   10.47618  -15.53727 1.000 34.64004  ? 121 ALA A CB  1 
ATOM   876  N N   . PHE A 1 122 ? 8.86635   8.16553   -13.35382 1.000 31.78880  ? 122 PHE A N   1 
ATOM   877  C CA  . PHE A 1 122 ? 8.00454   7.39638   -12.46090 1.000 31.58855  ? 122 PHE A CA  1 
ATOM   878  C C   . PHE A 1 122 ? 8.43780   7.56135   -11.00912 1.000 38.67024  ? 122 PHE A C   1 
ATOM   879  O O   . PHE A 1 122 ? 7.60277   7.76717   -10.11984 1.000 31.84542  ? 122 PHE A O   1 
ATOM   880  C CB  . PHE A 1 122 ? 8.02898   5.92340   -12.87816 1.000 35.56457  ? 122 PHE A CB  1 
ATOM   881  C CG  . PHE A 1 122 ? 7.24661   5.01160   -11.97240 1.000 35.27971  ? 122 PHE A CG  1 
ATOM   882  C CD1 . PHE A 1 122 ? 7.85028   4.41057   -10.87826 1.000 33.14652  ? 122 PHE A CD1 1 
ATOM   883  C CD2 . PHE A 1 122 ? 5.91605   4.72889   -12.23634 1.000 40.75576  ? 122 PHE A CD2 1 
ATOM   884  C CE1 . PHE A 1 122 ? 7.13570   3.56927   -10.04306 1.000 34.25362  ? 122 PHE A CE1 1 
ATOM   885  C CE2 . PHE A 1 122 ? 5.19086   3.87859   -11.41073 1.000 44.23715  ? 122 PHE A CE2 1 
ATOM   886  C CZ  . PHE A 1 122 ? 5.80448   3.29687   -10.31325 1.000 37.04583  ? 122 PHE A CZ  1 
ATOM   887  N N   . ILE A 1 123 ? 9.74895   7.47808   -10.75724 1.000 30.95252  ? 123 ILE A N   1 
ATOM   888  C CA  . ILE A 1 123 ? 10.27901  7.57364   -9.39846  1.000 31.94195  ? 123 ILE A CA  1 
ATOM   889  C C   . ILE A 1 123 ? 10.07700  8.97376   -8.83987  1.000 33.56906  ? 123 ILE A C   1 
ATOM   890  O O   . ILE A 1 123 ? 9.63517   9.14536   -7.69799  1.000 33.20457  ? 123 ILE A O   1 
ATOM   891  C CB  . ILE A 1 123 ? 11.76820  7.18499   -9.37884  1.000 29.23647  ? 123 ILE A CB  1 
ATOM   892  C CG1 . ILE A 1 123 ? 11.93247  5.69022   -9.62639  1.000 33.37519  ? 123 ILE A CG1 1 
ATOM   893  C CG2 . ILE A 1 123 ? 12.41446  7.60498   -8.06154  1.000 30.01122  ? 123 ILE A CG2 1 
ATOM   894  C CD1 . ILE A 1 123 ? 13.37095  5.28188   -9.90172  1.000 36.06708  ? 123 ILE A CD1 1 
ATOM   895  N N   . ILE A 1 124 ? 10.41305  9.99285   -9.63425  1.000 30.66453  ? 124 ILE A N   1 
ATOM   896  C CA  . ILE A 1 124 ? 10.31186  11.37284  -9.17953  1.000 30.45772  ? 124 ILE A CA  1 
ATOM   897  C C   . ILE A 1 124 ? 8.85221   11.77801  -8.98319  1.000 29.78971  ? 124 ILE A C   1 
ATOM   898  O O   . ILE A 1 124 ? 8.51257   12.46103  -8.00990  1.000 30.05443  ? 124 ILE A O   1 
ATOM   899  C CB  . ILE A 1 124 ? 11.04161  12.29616  -10.17406 1.000 33.19085  ? 124 ILE A CB  1 
ATOM   900  C CG1 . ILE A 1 124 ? 12.55739  12.14758  -10.01183 1.000 34.21875  ? 124 ILE A CG1 1 
ATOM   901  C CG2 . ILE A 1 124 ? 10.62488  13.74264  -9.98090  1.000 32.74045  ? 124 ILE A CG2 1 
ATOM   902  C CD1 . ILE A 1 124 ? 13.34350  12.54959  -11.24416 1.000 36.15869  ? 124 ILE A CD1 1 
ATOM   903  N N   . THR A 1 125 ? 7.96972   11.36669  -9.89703  1.000 30.65696  ? 125 THR A N   1 
ATOM   904  C CA  . THR A 1 125 ? 6.53790   11.61554  -9.72118  1.000 33.72558  ? 125 THR A CA  1 
ATOM   905  C C   . THR A 1 125 ? 6.04741   11.07628  -8.38301  1.000 30.40115  ? 125 THR A C   1 
ATOM   906  O O   . THR A 1 125 ? 5.34903   11.76845  -7.63265  1.000 31.93117  ? 125 THR A O   1 
ATOM   907  C CB  . THR A 1 125 ? 5.74631   10.97377  -10.86414 1.000 33.11020  ? 125 THR A CB  1 
ATOM   908  O OG1 . THR A 1 125 ? 6.02728   11.66040  -12.08757 1.000 35.63859  ? 125 THR A OG1 1 
ATOM   909  C CG2 . THR A 1 125 ? 4.24069   11.03754  -10.58544 1.000 32.80167  ? 125 THR A CG2 1 
ATOM   910  N N   . ALA A 1 126 ? 6.41720   9.83385   -8.06768  1.000 29.22534  ? 126 ALA A N   1 
ATOM   911  C CA  . ALA A 1 126 ? 5.95116   9.20488   -6.83890  1.000 31.26233  ? 126 ALA A CA  1 
ATOM   912  C C   . ALA A 1 126 ? 6.43839   9.95304   -5.60393  1.000 27.96509  ? 126 ALA A C   1 
ATOM   913  O O   . ALA A 1 126 ? 5.66226   10.20941  -4.67783  1.000 30.69864  ? 126 ALA A O   1 
ATOM   914  C CB  . ALA A 1 126 ? 6.40069   7.74567   -6.79953  1.000 28.82340  ? 126 ALA A CB  1 
ATOM   915  N N   . ILE A 1 127 ? 7.72905   10.29985  -5.55452  1.000 32.89659  ? 127 ILE A N   1 
ATOM   916  C CA  . ILE A 1 127 ? 8.21973   10.93442  -4.33454  1.000 28.64282  ? 127 ILE A CA  1 
ATOM   917  C C   . ILE A 1 127 ? 7.71361   12.36593  -4.22835  1.000 25.86185  ? 127 ILE A C   1 
ATOM   918  O O   . ILE A 1 127 ? 7.51572   12.87243  -3.12006  1.000 25.87530  ? 127 ILE A O   1 
ATOM   919  C CB  . ILE A 1 127 ? 9.75877   10.86928  -4.23266  1.000 38.89187  ? 127 ILE A CB  1 
ATOM   920  C CG1 . ILE A 1 127 ? 10.42921  11.77079  -5.25860  1.000 29.74720  ? 127 ILE A CG1 1 
ATOM   921  C CG2 . ILE A 1 127 ? 10.24754  9.43413   -4.38117  1.000 33.79977  ? 127 ILE A CG2 1 
ATOM   922  C CD1 . ILE A 1 127 ? 11.95992  11.66936  -5.22511  1.000 47.88450  ? 127 ILE A CD1 1 
ATOM   923  N N   . ARG A 1 128 ? 7.46547   13.03202  -5.35958  1.000 27.39287  ? 128 ARG A N   1 
ATOM   924  C CA  . ARG A 1 128 ? 6.95217   14.39998  -5.29968  1.000 30.43789  ? 128 ARG A CA  1 
ATOM   925  C C   . ARG A 1 128 ? 5.51836   14.43831  -4.78718  1.000 26.26381  ? 128 ARG A C   1 
ATOM   926  O O   . ARG A 1 128 ? 5.15004   15.35478  -4.04284  1.000 26.92864  ? 128 ARG A O   1 
ATOM   927  C CB  . ARG A 1 128 ? 7.05762   15.06473  -6.67042  1.000 29.17487  ? 128 ARG A CB  1 
ATOM   928  C CG  . ARG A 1 128 ? 8.46516   15.56804  -6.98534  1.000 35.01910  ? 128 ARG A CG  1 
ATOM   929  C CD  . ARG A 1 128 ? 8.50651   16.24577  -8.33444  1.000 36.34592  ? 128 ARG A CD  1 
ATOM   930  N NE  . ARG A 1 128 ? 9.80622   16.84582  -8.61880  1.000 35.79675  ? 128 ARG A NE  1 
ATOM   931  C CZ  . ARG A 1 128 ? 10.13025  17.38915  -9.78754  1.000 39.63470  ? 128 ARG A CZ  1 
ATOM   932  N NH1 . ARG A 1 128 ? 9.24653   17.40165  -10.77499 1.000 41.50300  ? 128 ARG A NH1 1 
ATOM   933  N NH2 . ARG A 1 128 ? 11.33590  17.91203  -9.97149  1.000 39.59376  ? 128 ARG A NH2 1 
ATOM   934  N N   . LYS A 1 129 ? 4.69409   13.45699  -5.17692  1.000 31.14318  ? 129 LYS A N   1 
ATOM   935  C CA  . LYS A 1 129 ? 3.35065   13.34132  -4.60712  1.000 28.35966  ? 129 LYS A CA  1 
ATOM   936  C C   . LYS A 1 129 ? 3.42331   13.09936  -3.11098  1.000 27.97523  ? 129 LYS A C   1 
ATOM   937  O O   . LYS A 1 129 ? 2.68408   13.70827  -2.33314  1.000 27.65798  ? 129 LYS A O   1 
ATOM   938  C CB  . LYS A 1 129 ? 2.57490   12.19900  -5.26832  1.000 25.13606  ? 129 LYS A CB  1 
ATOM   939  C CG  . LYS A 1 129 ? 2.09447   12.46211  -6.68330  1.000 26.44850  ? 129 LYS A CG  1 
ATOM   940  C CD  . LYS A 1 129 ? 1.53683   11.18020  -7.26176  1.000 30.75531  ? 129 LYS A CD  1 
ATOM   941  C CE  . LYS A 1 129 ? 1.03569   11.36280  -8.67537  1.000 40.06093  ? 129 LYS A CE  1 
ATOM   942  N NZ  . LYS A 1 129 ? 0.67692   10.05267  -9.28709  1.000 39.66865  ? 129 LYS A NZ  1 
ATOM   943  N N   . ALA A 1 130 ? 4.29629   12.18152  -2.69274  1.000 26.60555  ? 130 ALA A N   1 
ATOM   944  C CA  . ALA A 1 130 ? 4.43764   11.89196  -1.27184  1.000 26.68099  ? 130 ALA A CA  1 
ATOM   945  C C   . ALA A 1 130 ? 4.92816   13.11556  -0.50543  1.000 24.47128  ? 130 ALA A C   1 
ATOM   946  O O   . ALA A 1 130 ? 4.42325   13.42019  0.58107   1.000 29.23479  ? 130 ALA A O   1 
ATOM   947  C CB  . ALA A 1 130 ? 5.38884   10.71016  -1.07638  1.000 25.27966  ? 130 ALA A CB  1 
ATOM   948  N N   . ASN A 1 131 ? 5.90476   13.83524  -1.05931  1.000 25.29558  ? 131 ASN A N   1 
ATOM   949  C CA  . ASN A 1 131 ? 6.43567   15.00912  -0.36619  1.000 29.69381  ? 131 ASN A CA  1 
ATOM   950  C C   . ASN A 1 131 ? 5.39662   16.11856  -0.27913  1.000 29.11300  ? 131 ASN A C   1 
ATOM   951  O O   . ASN A 1 131 ? 5.29746   16.80284  0.74623   1.000 31.82046  ? 131 ASN A O   1 
ATOM   952  C CB  . ASN A 1 131 ? 7.69946   15.50444  -1.06461  1.000 28.63203  ? 131 ASN A CB  1 
ATOM   953  C CG  . ASN A 1 131 ? 8.89692   14.61121  -0.79998  1.000 30.91773  ? 131 ASN A CG  1 
ATOM   954  O OD1 . ASN A 1 131 ? 8.87760   13.79338  0.12148   1.000 33.09030  ? 131 ASN A OD1 1 
ATOM   955  N ND2 . ASN A 1 131 ? 9.95531   14.77811  -1.59203  1.000 32.27435  ? 131 ASN A ND2 1 
ATOM   956  N N   . LEU A 1 132 ? 4.61770   16.31780  -1.34595  1.000 29.69307  ? 132 LEU A N   1 
ATOM   957  C CA  . LEU A 1 132 ? 3.50897   17.26445  -1.27923  1.000 30.16582  ? 132 LEU A CA  1 
ATOM   958  C C   . LEU A 1 132 ? 2.53890   16.88464  -0.17000  1.000 29.24327  ? 132 LEU A C   1 
ATOM   959  O O   . LEU A 1 132 ? 2.04875   17.75064  0.56391   1.000 32.22906  ? 132 LEU A O   1 
ATOM   960  C CB  . LEU A 1 132 ? 2.78091   17.32188  -2.62583  1.000 26.60792  ? 132 LEU A CB  1 
ATOM   961  C CG  . LEU A 1 132 ? 1.51226   18.18171  -2.63818  1.000 29.95931  ? 132 LEU A CG  1 
ATOM   962  C CD1 . LEU A 1 132 ? 1.84626   19.61478  -2.22888  1.000 29.22578  ? 132 LEU A CD1 1 
ATOM   963  C CD2 . LEU A 1 132 ? 0.86164   18.16319  -4.01882  1.000 26.85931  ? 132 LEU A CD2 1 
ATOM   964  N N   . LEU A 1 133 ? 2.26899   15.58656  -0.02285  1.000 27.19288  ? 133 LEU A N   1 
ATOM   965  C CA  . LEU A 1 133 ? 1.34540   15.11624  1.00617   1.000 29.84626  ? 133 LEU A CA  1 
ATOM   966  C C   . LEU A 1 133 ? 1.89819   15.35607  2.40247   1.000 30.91572  ? 133 LEU A C   1 
ATOM   967  O O   . LEU A 1 133 ? 1.15248   15.73922  3.31221   1.000 35.40537  ? 133 LEU A O   1 
ATOM   968  C CB  . LEU A 1 133 ? 1.06439   13.62689  0.81287   1.000 31.55908  ? 133 LEU A CB  1 
ATOM   969  C CG  . LEU A 1 133 ? -0.31740  13.20042  0.34546   1.000 34.93086  ? 133 LEU A CG  1 
ATOM   970  C CD1 . LEU A 1 133 ? -0.45003  11.69330  0.49241   1.000 32.11813  ? 133 LEU A CD1 1 
ATOM   971  C CD2 . LEU A 1 133 ? -1.40232  13.93944  1.13586   1.000 31.88411  ? 133 LEU A CD2 1 
ATOM   972  N N   . THR A 1 134 ? 3.19369   15.10025  2.59869   1.000 29.03258  ? 134 THR A N   1 
ATOM   973  C CA  . THR A 1 134 ? 3.82276   15.39270  3.88251   1.000 32.38254  ? 134 THR A CA  1 
ATOM   974  C C   . THR A 1 134 ? 3.61445   16.85445  4.25981   1.000 32.78322  ? 134 THR A C   1 
ATOM   975  O O   . THR A 1 134 ? 3.24965   17.17293  5.39948   1.000 33.26833  ? 134 THR A O   1 
ATOM   976  C CB  . THR A 1 134 ? 5.31450   15.05266  3.82363   1.000 31.13653  ? 134 THR A CB  1 
ATOM   977  O OG1 . THR A 1 134 ? 5.48016   13.64564  3.59614   1.000 34.94976  ? 134 THR A OG1 1 
ATOM   978  C CG2 . THR A 1 134 ? 6.00435   15.43383  5.12541   1.000 35.68366  ? 134 THR A CG2 1 
ATOM   979  N N   . PHE A 1 135 ? 3.81629   17.75553  3.29848   1.000 31.12220  ? 135 PHE A N   1 
ATOM   980  C CA  . PHE A 1 135 ? 3.55670   19.17440  3.52397   1.000 29.32687  ? 135 PHE A CA  1 
ATOM   981  C C   . PHE A 1 135 ? 2.09557   19.41649  3.89761   1.000 29.99699  ? 135 PHE A C   1 
ATOM   982  O O   . PHE A 1 135 ? 1.79542   20.04057  4.92215   1.000 31.18928  ? 135 PHE A O   1 
ATOM   983  C CB  . PHE A 1 135 ? 3.93329   19.96728  2.27004   1.000 29.31205  ? 135 PHE A CB  1 
ATOM   984  C CG  . PHE A 1 135 ? 3.84646   21.45666  2.44546   1.000 29.89323  ? 135 PHE A CG  1 
ATOM   985  C CD1 . PHE A 1 135 ? 2.62198   22.10611  2.41774   1.000 30.73608  ? 135 PHE A CD1 1 
ATOM   986  C CD2 . PHE A 1 135 ? 4.99603   22.20781  2.63491   1.000 33.79880  ? 135 PHE A CD2 1 
ATOM   987  C CE1 . PHE A 1 135 ? 2.54317   23.47994  2.58454   1.000 35.56345  ? 135 PHE A CE1 1 
ATOM   988  C CE2 . PHE A 1 135 ? 4.92595   23.58342  2.80246   1.000 34.74878  ? 135 PHE A CE2 1 
ATOM   989  C CZ  . PHE A 1 135 ? 3.69757   24.21594  2.77878   1.000 32.18205  ? 135 PHE A CZ  1 
ATOM   990  N N   . LEU A 1 136 ? 1.16840   18.93943  3.06234   1.000 34.01851  ? 136 LEU A N   1 
ATOM   991  C CA  . LEU A 1 136 ? -0.24951  19.21538  3.28566   1.000 30.14546  ? 136 LEU A CA  1 
ATOM   992  C C   . LEU A 1 136 ? -0.72704  18.63605  4.61065   1.000 33.03329  ? 136 LEU A C   1 
ATOM   993  O O   . LEU A 1 136 ? -1.41166  19.31391  5.38649   1.000 30.99185  ? 136 LEU A O   1 
ATOM   994  C CB  . LEU A 1 136 ? -1.08532  18.65547  2.13095   1.000 30.34099  ? 136 LEU A CB  1 
ATOM   995  C CG  . LEU A 1 136 ? -0.97219  19.30658  0.75192   1.000 32.14442  ? 136 LEU A CG  1 
ATOM   996  C CD1 . LEU A 1 136 ? -1.91833  18.60890  -0.22375  1.000 29.26828  ? 136 LEU A CD1 1 
ATOM   997  C CD2 . LEU A 1 136 ? -1.30166  20.79255  0.84427   1.000 31.27466  ? 136 LEU A CD2 1 
ATOM   998  N N   . LEU A 1 137 ? -0.38984  17.36907  4.88043   1.000 31.96067  ? 137 LEU A N   1 
ATOM   999  C CA  . LEU A 1 137 ? -0.85117  16.72776  6.10964   1.000 33.87031  ? 137 LEU A CA  1 
ATOM   1000 C C   . LEU A 1 137 ? -0.22099  17.35498  7.34638   1.000 31.90935  ? 137 LEU A C   1 
ATOM   1001 O O   . LEU A 1 137 ? -0.83752  17.35180  8.41901   1.000 32.99631  ? 137 LEU A O   1 
ATOM   1002 C CB  . LEU A 1 137 ? -0.55702  15.22411  6.07537   1.000 29.76207  ? 137 LEU A CB  1 
ATOM   1003 C CG  . LEU A 1 137 ? -1.38246  14.39989  5.08496   1.000 31.86365  ? 137 LEU A CG  1 
ATOM   1004 C CD1 . LEU A 1 137 ? -0.91322  12.95736  5.08480   1.000 31.33855  ? 137 LEU A CD1 1 
ATOM   1005 C CD2 . LEU A 1 137 ? -2.89096  14.48211  5.40193   1.000 29.22862  ? 137 LEU A CD2 1 
ATOM   1006 N N   . THR A 1 138 ? 1.00423   17.87119  7.23045   1.000 32.95954  ? 138 THR A N   1 
ATOM   1007 C CA  . THR A 1 138 ? 1.57884   18.62940  8.33937   1.000 37.53442  ? 138 THR A CA  1 
ATOM   1008 C C   . THR A 1 138 ? 0.79652   19.91747  8.58223   1.000 40.17463  ? 138 THR A C   1 
ATOM   1009 O O   . THR A 1 138 ? 0.52566   20.27817  9.73379   1.000 35.20585  ? 138 THR A O   1 
ATOM   1010 C CB  . THR A 1 138 ? 3.05631   18.93289  8.07014   1.000 36.50530  ? 138 THR A CB  1 
ATOM   1011 O OG1 . THR A 1 138 ? 3.79648   17.70605  7.99499   1.000 37.34464  ? 138 THR A OG1 1 
ATOM   1012 C CG2 . THR A 1 138 ? 3.64509   19.79195  9.18308   1.000 39.25062  ? 138 THR A CG2 1 
ATOM   1013 N N   . SER A 1 139 ? 0.42929   20.62587  7.50604   1.000 36.32413  ? 139 SER A N   1 
ATOM   1014 C CA  . SER A 1 139 ? -0.42389  21.80649  7.63513   1.000 37.60715  ? 139 SER A CA  1 
ATOM   1015 C C   . SER A 1 139 ? -1.69971  21.48184  8.39714   1.000 34.19353  ? 139 SER A C   1 
ATOM   1016 O O   . SER A 1 139 ? -2.11179  22.22467  9.29360   1.000 38.06807  ? 139 SER A O   1 
ATOM   1017 C CB  . SER A 1 139 ? -0.77364  22.36314  6.25231   1.000 35.09774  ? 139 SER A CB  1 
ATOM   1018 O OG  . SER A 1 139 ? 0.38470   22.81196  5.57705   1.000 43.01303  ? 139 SER A OG  1 
ATOM   1019 N N   . LEU A 1 140 ? -2.34427  20.37466  8.04517   1.000 38.30588  ? 140 LEU A N   1 
ATOM   1020 C CA  . LEU A 1 140 ? -3.57537  19.95200  8.69839   1.000 37.59916  ? 140 LEU A CA  1 
ATOM   1021 C C   . LEU A 1 140 ? -3.32996  19.32457  10.06030  1.000 40.82592  ? 140 LEU A C   1 
ATOM   1022 O O   . LEU A 1 140 ? -4.27605  18.81227  10.66880  1.000 44.33363  ? 140 LEU A O   1 
ATOM   1023 C CB  . LEU A 1 140 ? -4.32806  18.97409  7.79794   1.000 35.62755  ? 140 LEU A CB  1 
ATOM   1024 C CG  . LEU A 1 140 ? -4.72093  19.58268  6.45297   1.000 33.72962  ? 140 LEU A CG  1 
ATOM   1025 C CD1 . LEU A 1 140 ? -5.09988  18.48588  5.46994   1.000 39.22166  ? 140 LEU A CD1 1 
ATOM   1026 C CD2 . LEU A 1 140 ? -5.87047  20.56963  6.64408   1.000 40.01038  ? 140 LEU A CD2 1 
ATOM   1027 N N   . ASN A 1 141 ? -2.08499  19.35808  10.53702  1.000 39.97335  ? 141 ASN A N   1 
ATOM   1028 C CA  . ASN A 1 141 ? -1.69615  18.80674  11.83471  1.000 45.54916  ? 141 ASN A CA  1 
ATOM   1029 C C   . ASN A 1 141 ? -2.06359  17.32814  11.95317  1.000 49.76360  ? 141 ASN A C   1 
ATOM   1030 O O   . ASN A 1 141 ? -2.44125  16.84337  13.02108  1.000 51.53622  ? 141 ASN A O   1 
ATOM   1031 C CB  . ASN A 1 141 ? -2.29673  19.61557  12.98316  1.000 47.38872  ? 141 ASN A CB  1 
ATOM   1032 C CG  . ASN A 1 141 ? -1.53779  19.42432  14.27132  1.000 59.09275  ? 141 ASN A CG  1 
ATOM   1033 O OD1 . ASN A 1 141 ? -1.95118  18.65948  15.13545  1.000 62.55762  ? 141 ASN A OD1 1 
ATOM   1034 N ND2 . ASN A 1 141 ? -0.39410  20.08932  14.38974  1.000 72.37999  ? 141 ASN A ND2 1 
ATOM   1035 N N   . CYS A 1 142 ? -1.93984  16.59975  10.84457  1.000 46.20643  ? 142 CYS A N   1 
ATOM   1036 C CA  . CYS A 1 142 ? -2.16712  15.16221  10.83706  1.000 47.25000  ? 142 CYS A CA  1 
ATOM   1037 C C   . CYS A 1 142 ? -0.87859  14.35675  10.90330  1.000 44.35656  ? 142 CYS A C   1 
ATOM   1038 O O   . CYS A 1 142 ? -0.94282  13.12670  10.99555  1.000 56.47680  ? 142 CYS A O   1 
ATOM   1039 C CB  . CYS A 1 142 ? -2.96479  14.75868  9.59391   1.000 37.01625  ? 142 CYS A CB  1 
ATOM   1040 S SG  . CYS A 1 142 ? -4.66133  15.33720  9.64695   1.000 48.70803  ? 142 CYS A SG  1 
ATOM   1041 N N   . LEU A 1 143 ? 0.27612   15.01043  10.84928  1.000 43.24089  ? 143 LEU A N   1 
ATOM   1042 C CA  . LEU A 1 143 ? 1.56251   14.37806  11.09995  1.000 44.99101  ? 143 LEU A CA  1 
ATOM   1043 C C   . LEU A 1 143 ? 2.18646   14.97425  12.35392  1.000 55.40885  ? 143 LEU A C   1 
ATOM   1044 O O   . LEU A 1 143 ? 1.74396   16.00341  12.87146  1.000 67.07500  ? 143 LEU A O   1 
ATOM   1045 C CB  . LEU A 1 143 ? 2.50803   14.53924  9.90499   1.000 41.20683  ? 143 LEU A CB  1 
ATOM   1046 C CG  . LEU A 1 143 ? 2.05761   13.88563  8.60242   1.000 44.46506  ? 143 LEU A CG  1 
ATOM   1047 C CD1 . LEU A 1 143 ? 3.16091   13.95284  7.56010   1.000 42.74684  ? 143 LEU A CD1 1 
ATOM   1048 C CD2 . LEU A 1 143 ? 1.62047   12.44169  8.84660   1.000 53.64069  ? 143 LEU A CD2 1 
ATOM   1049 N N   . ASN A 1 144 ? 3.23717   14.31339  12.83763  1.000 66.66507  ? 144 ASN A N   1 
ATOM   1050 C CA  . ASN A 1 144 ? 3.85016   14.69275  14.10309  1.000 66.55545  ? 144 ASN A CA  1 
ATOM   1051 C C   . ASN A 1 144 ? 4.76247   15.90924  13.99129  1.000 70.51036  ? 144 ASN A C   1 
ATOM   1052 O O   . ASN A 1 144 ? 5.23560   16.40033  15.02247  1.000 74.09144  ? 144 ASN A O   1 
ATOM   1053 C CB  . ASN A 1 144 ? 4.63212   13.50760  14.67437  1.000 72.19089  ? 144 ASN A CB  1 
ATOM   1054 C CG  . ASN A 1 144 ? 4.72044   13.54410  16.18656  1.000 82.82333  ? 144 ASN A CG  1 
ATOM   1055 O OD1 . ASN A 1 144 ? 5.74378   13.92877  16.75231  1.000 84.03499  ? 144 ASN A OD1 1 
ATOM   1056 N ND2 . ASN A 1 144 ? 3.64065   13.14560  16.85137  1.000 90.97711  ? 144 ASN A ND2 1 
ATOM   1057 N N   . TYR A 1 145 ? 5.01681   16.41118  12.78503  1.000 65.20095  ? 145 TYR A N   1 
ATOM   1058 C CA  . TYR A 1 145 ? 5.88207   17.57181  12.63400  1.000 52.85508  ? 145 TYR A CA  1 
ATOM   1059 C C   . TYR A 1 145 ? 5.16878   18.84249  13.07821  1.000 60.43410  ? 145 TYR A C   1 
ATOM   1060 O O   . TYR A 1 145 ? 3.94211   18.95791  13.00317  1.000 56.21961  ? 145 TYR A O   1 
ATOM   1061 C CB  . TYR A 1 145 ? 6.33468   17.73204  11.18399  1.000 50.84623  ? 145 TYR A CB  1 
ATOM   1062 C CG  . TYR A 1 145 ? 7.00628   16.52051  10.58767  1.000 56.02543  ? 145 TYR A CG  1 
ATOM   1063 C CD1 . TYR A 1 145 ? 6.32329   15.69249  9.70448   1.000 49.65954  ? 145 TYR A CD1 1 
ATOM   1064 C CD2 . TYR A 1 145 ? 8.32573   16.20911  10.89393  1.000 61.59726  ? 145 TYR A CD2 1 
ATOM   1065 C CE1 . TYR A 1 145 ? 6.92864   14.58832  9.14723   1.000 50.33561  ? 145 TYR A CE1 1 
ATOM   1066 C CE2 . TYR A 1 145 ? 8.94355   15.09916  10.34151  1.000 55.98255  ? 145 TYR A CE2 1 
ATOM   1067 C CZ  . TYR A 1 145 ? 8.23941   14.29409  9.46886   1.000 60.21042  ? 145 TYR A CZ  1 
ATOM   1068 O OH  . TYR A 1 145 ? 8.84185   13.18991  8.91296   1.000 64.71649  ? 145 TYR A OH  1 
ATOM   1069 N N   . GLY A 1 146 ? 5.95457   19.80744  13.53988  1.000 63.54604  ? 146 GLY A N   1 
ATOM   1070 C CA  . GLY A 1 146 ? 5.41010   21.10444  13.86898  1.000 59.51481  ? 146 GLY A CA  1 
ATOM   1071 C C   . GLY A 1 146 ? 5.22305   21.97591  12.64071  1.000 56.55740  ? 146 GLY A C   1 
ATOM   1072 O O   . GLY A 1 146 ? 5.71644   21.68823  11.55068  1.000 50.24738  ? 146 GLY A O   1 
ATOM   1073 N N   . PHE A 1 147 ? 4.49389   23.07705  12.83638  1.000 59.99032  ? 147 PHE A N   1 
ATOM   1074 C CA  . PHE A 1 147 ? 4.26617   24.00887  11.73785  1.000 49.26144  ? 147 PHE A CA  1 
ATOM   1075 C C   . PHE A 1 147 ? 5.56632   24.63088  11.24348  1.000 48.50930  ? 147 PHE A C   1 
ATOM   1076 O O   . PHE A 1 147 ? 5.65693   25.03208  10.07752  1.000 45.75264  ? 147 PHE A O   1 
ATOM   1077 C CB  . PHE A 1 147 ? 3.28973   25.10271  12.16977  1.000 58.63261  ? 147 PHE A CB  1 
ATOM   1078 C CG  . PHE A 1 147 ? 2.52120   25.70140  11.03243  1.000 55.19880  ? 147 PHE A CG  1 
ATOM   1079 C CD1 . PHE A 1 147 ? 3.10248   26.65222  10.20906  1.000 49.89352  ? 147 PHE A CD1 1 
ATOM   1080 C CD2 . PHE A 1 147 ? 1.22026   25.30216  10.77580  1.000 52.74412  ? 147 PHE A CD2 1 
ATOM   1081 C CE1 . PHE A 1 147 ? 2.39892   27.19853  9.15560   1.000 50.58795  ? 147 PHE A CE1 1 
ATOM   1082 C CE2 . PHE A 1 147 ? 0.50985   25.84581  9.72407   1.000 49.36016  ? 147 PHE A CE2 1 
ATOM   1083 C CZ  . PHE A 1 147 ? 1.10054   26.79379  8.91301   1.000 45.20581  ? 147 PHE A CZ  1 
ATOM   1084 N N   . GLU A 1 148 ? 6.58208   24.71346  12.10576  1.000 46.17098  ? 148 GLU A N   1 
ATOM   1085 C CA  . GLU A 1 148 ? 7.84493   25.33690  11.72699  1.000 48.54774  ? 148 GLU A CA  1 
ATOM   1086 C C   . GLU A 1 148 ? 8.57785   24.56261  10.63881  1.000 46.98458  ? 148 GLU A C   1 
ATOM   1087 O O   . GLU A 1 148 ? 9.44860   25.13169  9.97247   1.000 54.05791  ? 148 GLU A O   1 
ATOM   1088 C CB  . GLU A 1 148 ? 8.74262   25.49291  12.95959  1.000 55.69872  ? 148 GLU A CB  1 
ATOM   1089 C CG  . GLU A 1 148 ? 9.15319   24.17981  13.62884  1.000 59.51993  ? 148 GLU A CG  1 
ATOM   1090 C CD  . GLU A 1 148 ? 8.04276   23.55238  14.46409  1.000 67.28969  ? 148 GLU A CD  1 
ATOM   1091 O OE1 . GLU A 1 148 ? 7.00969   24.21784  14.69842  1.000 68.11457  ? 148 GLU A OE1 1 
ATOM   1092 O OE2 . GLU A 1 148 ? 8.20489   22.38750  14.88546  1.000 72.40070  ? 148 GLU A OE2 1 
ATOM   1093 N N   . LEU A 1 149 ? 8.24874   23.28283  10.44176  1.000 52.43643  ? 149 LEU A N   1 
ATOM   1094 C CA  . LEU A 1 149 ? 8.88960   22.49635  9.39082   1.000 52.88437  ? 149 LEU A CA  1 
ATOM   1095 C C   . LEU A 1 149 ? 8.44135   22.94041  8.00097   1.000 50.36273  ? 149 LEU A C   1 
ATOM   1096 O O   . LEU A 1 149 ? 9.22421   22.87046  7.04501   1.000 44.86824  ? 149 LEU A O   1 
ATOM   1097 C CB  . LEU A 1 149 ? 8.58768   21.01079  9.61375   1.000 57.36474  ? 149 LEU A CB  1 
ATOM   1098 C CG  . LEU A 1 149 ? 9.20635   19.91647  8.73461   1.000 58.94965  ? 149 LEU A CG  1 
ATOM   1099 C CD1 . LEU A 1 149 ? 8.29246   19.57016  7.57062   1.000 58.60075  ? 149 LEU A CD1 1 
ATOM   1100 C CD2 . LEU A 1 149 ? 10.59925  20.29726  8.24150   1.000 53.05580  ? 149 LEU A CD2 1 
ATOM   1101 N N   . LEU A 1 150 ? 7.19991   23.41634  7.88010   1.000 46.65976  ? 150 LEU A N   1 
ATOM   1102 C CA  . LEU A 1 150 ? 6.63859   23.76160  6.57746   1.000 47.12492  ? 150 LEU A CA  1 
ATOM   1103 C C   . LEU A 1 150 ? 7.49390   24.79338  5.84966   1.000 42.89404  ? 150 LEU A C   1 
ATOM   1104 O O   . LEU A 1 150 ? 7.78407   24.64555  4.65655   1.000 36.16006  ? 150 LEU A O   1 
ATOM   1105 C CB  . LEU A 1 150 ? 5.21007   24.27555  6.75558   1.000 37.59354  ? 150 LEU A CB  1 
ATOM   1106 C CG  . LEU A 1 150 ? 4.24490   23.24702  7.34263   1.000 39.58807  ? 150 LEU A CG  1 
ATOM   1107 C CD1 . LEU A 1 150 ? 2.87911   23.85319  7.58893   1.000 40.11585  ? 150 LEU A CD1 1 
ATOM   1108 C CD2 . LEU A 1 150 ? 4.14251   22.06262  6.40065   1.000 37.06069  ? 150 LEU A CD2 1 
ATOM   1109 N N   . GLN A 1 151 ? 7.90830   25.84754  6.55374   1.000 40.55000  ? 151 GLN A N   1 
ATOM   1110 C CA  . GLN A 1 151 ? 8.66269   26.91728  5.90699   1.000 46.12994  ? 151 GLN A CA  1 
ATOM   1111 C C   . GLN A 1 151 ? 9.96761   26.41416  5.29872   1.000 42.17919  ? 151 GLN A C   1 
ATOM   1112 O O   . GLN A 1 151 ? 10.39536  26.91306  4.25042   1.000 48.60507  ? 151 GLN A O   1 
ATOM   1113 C CB  . GLN A 1 151 ? 8.94349   28.03530  6.91164   1.000 49.30091  ? 151 GLN A CB  1 
ATOM   1114 C CG  . GLN A 1 151 ? 9.70468   29.20609  6.32698   1.000 52.98439  ? 151 GLN A CG  1 
ATOM   1115 C CD  . GLN A 1 151 ? 10.07095  30.23147  7.36938   1.000 51.86456  ? 151 GLN A CD  1 
ATOM   1116 O OE1 . GLN A 1 151 ? 9.89663   31.42988  7.16106   1.000 59.65072  ? 151 GLN A OE1 1 
ATOM   1117 N NE2 . GLN A 1 151 ? 10.58296  29.76715  8.50364   1.000 57.43566  ? 151 GLN A NE2 1 
ATOM   1118 N N   . SER A 1 152 ? 10.60371  25.42192  5.92429   1.000 44.60363  ? 152 SER A N   1 
ATOM   1119 C CA  . SER A 1 152 ? 11.91123  24.96283  5.46785   1.000 45.76194  ? 152 SER A CA  1 
ATOM   1120 C C   . SER A 1 152 ? 11.83776  24.06657  4.23778   1.000 44.33619  ? 152 SER A C   1 
ATOM   1121 O O   . SER A 1 152 ? 12.84619  23.90483  3.54434   1.000 45.07133  ? 152 SER A O   1 
ATOM   1122 C CB  . SER A 1 152 ? 12.62985  24.21192  6.58957   1.000 51.94594  ? 152 SER A CB  1 
ATOM   1123 O OG  . SER A 1 152 ? 12.01173  22.96276  6.84446   1.000 57.72585  ? 152 SER A OG  1 
ATOM   1124 N N   . ILE A 1 153 ? 10.68702  23.45962  3.96100   1.000 45.95987  ? 153 ILE A N   1 
ATOM   1125 C CA  . ILE A 1 153 ? 10.54665  22.59022  2.79987   1.000 40.74704  ? 153 ILE A CA  1 
ATOM   1126 C C   . ILE A 1 153 ? 9.72519   23.22426  1.69568   1.000 41.63993  ? 153 ILE A C   1 
ATOM   1127 O O   . ILE A 1 153 ? 9.52641   22.58693  0.65004   1.000 38.06121  ? 153 ILE A O   1 
ATOM   1128 C CB  . ILE A 1 153 ? 9.95262   21.22177  3.18512   1.000 43.43822  ? 153 ILE A CB  1 
ATOM   1129 C CG1 . ILE A 1 153 ? 8.56460   21.39055  3.80762   1.000 40.18138  ? 153 ILE A CG1 1 
ATOM   1130 C CG2 . ILE A 1 153 ? 10.88780  20.47228  4.12977   1.000 39.43204  ? 153 ILE A CG2 1 
ATOM   1131 C CD1 . ILE A 1 153 ? 7.84878   20.07857  4.04754   1.000 47.81328  ? 153 ILE A CD1 1 
ATOM   1132 N N   . PHE A 1 154 ? 9.24971   24.46139  1.88036   1.000 39.61250  ? 154 PHE A N   1 
ATOM   1133 C CA  . PHE A 1 154 ? 8.30242   25.02925  0.92653   1.000 37.79255  ? 154 PHE A CA  1 
ATOM   1134 C C   . PHE A 1 154 ? 8.89120   25.09984  -0.47502  1.000 32.25019  ? 154 PHE A C   1 
ATOM   1135 O O   . PHE A 1 154 ? 8.27128   24.64539  -1.44199  1.000 33.87549  ? 154 PHE A O   1 
ATOM   1136 C CB  . PHE A 1 154 ? 7.84228   26.42115  1.36795   1.000 37.40088  ? 154 PHE A CB  1 
ATOM   1137 C CG  . PHE A 1 154 ? 6.97101   27.10573  0.35221   1.000 33.88689  ? 154 PHE A CG  1 
ATOM   1138 C CD1 . PHE A 1 154 ? 5.60220   26.89662  0.34450   1.000 36.73229  ? 154 PHE A CD1 1 
ATOM   1139 C CD2 . PHE A 1 154 ? 7.52307   27.93711  -0.61320  1.000 39.07623  ? 154 PHE A CD2 1 
ATOM   1140 C CE1 . PHE A 1 154 ? 4.79358   27.51511  -0.59979  1.000 37.11475  ? 154 PHE A CE1 1 
ATOM   1141 C CE2 . PHE A 1 154 ? 6.72247   28.55666  -1.56045  1.000 37.33441  ? 154 PHE A CE2 1 
ATOM   1142 C CZ  . PHE A 1 154 ? 5.35574   28.34595  -1.55182  1.000 33.64745  ? 154 PHE A CZ  1 
ATOM   1143 N N   . LEU A 1 155 ? 10.07702  25.69449  -0.61219  1.000 36.14429  ? 155 LEU A N   1 
ATOM   1144 C CA  . LEU A 1 155 ? 10.62797  25.91820  -1.94533  1.000 35.90186  ? 155 LEU A CA  1 
ATOM   1145 C C   . LEU A 1 155 ? 10.95977  24.60295  -2.64768  1.000 35.10436  ? 155 LEU A C   1 
ATOM   1146 O O   . LEU A 1 155 ? 10.76991  24.48051  -3.86277  1.000 34.25769  ? 155 LEU A O   1 
ATOM   1147 C CB  . LEU A 1 155 ? 11.86449  26.81317  -1.85626  1.000 40.72728  ? 155 LEU A CB  1 
ATOM   1148 C CG  . LEU A 1 155 ? 11.60233  28.24492  -1.37551  1.000 37.55541  ? 155 LEU A CG  1 
ATOM   1149 C CD1 . LEU A 1 155 ? 12.91453  28.99531  -1.20398  1.000 37.91942  ? 155 LEU A CD1 1 
ATOM   1150 C CD2 . LEU A 1 155 ? 10.68984  28.98361  -2.33861  1.000 35.00877  ? 155 LEU A CD2 1 
ATOM   1151 N N   . ASP A 1 156 ? 11.47111  23.61566  -1.90779  1.000 33.83958  ? 156 ASP A N   1 
ATOM   1152 C CA  . ASP A 1 156 ? 11.77113  22.31866  -2.51179  1.000 36.83272  ? 156 ASP A CA  1 
ATOM   1153 C C   . ASP A 1 156 ? 10.53639  21.70933  -3.17061  1.000 36.31568  ? 156 ASP A C   1 
ATOM   1154 O O   . ASP A 1 156 ? 10.62131  21.12847  -4.25890  1.000 36.93941  ? 156 ASP A O   1 
ATOM   1155 C CB  . ASP A 1 156 ? 12.32405  21.36499  -1.45285  1.000 39.73559  ? 156 ASP A CB  1 
ATOM   1156 C CG  . ASP A 1 156 ? 13.76482  21.66720  -1.08217  1.000 49.24094  ? 156 ASP A CG  1 
ATOM   1157 O OD1 . ASP A 1 156 ? 14.47685  22.28505  -1.90104  1.000 48.39492  ? 156 ASP A OD1 1 
ATOM   1158 O OD2 . ASP A 1 156 ? 14.18381  21.27657  0.02805   1.000 54.62815  ? 156 ASP A OD2 1 
ATOM   1159 N N   . ILE A 1 157 ? 9.38156   21.83334  -2.52484  1.000 30.84436  ? 157 ILE A N   1 
ATOM   1160 C CA  . ILE A 1 157 ? 8.16180   21.21508  -3.03508  1.000 32.93020  ? 157 ILE A CA  1 
ATOM   1161 C C   . ILE A 1 157 ? 7.53077   22.07143  -4.12744  1.000 36.11610  ? 157 ILE A C   1 
ATOM   1162 O O   . ILE A 1 157 ? 7.27417   21.59743  -5.23961  1.000 36.88705  ? 157 ILE A O   1 
ATOM   1163 C CB  . ILE A 1 157 ? 7.18916   20.95825  -1.86990  1.000 32.55240  ? 157 ILE A CB  1 
ATOM   1164 C CG1 . ILE A 1 157 ? 7.72423   19.81742  -0.99062  1.000 32.75470  ? 157 ILE A CG1 1 
ATOM   1165 C CG2 . ILE A 1 157 ? 5.78409   20.64505  -2.38192  1.000 31.91535  ? 157 ILE A CG2 1 
ATOM   1166 C CD1 . ILE A 1 157 ? 7.08315   19.75095  0.37607   1.000 37.09845  ? 157 ILE A CD1 1 
ATOM   1167 N N   . PHE A 1 158 ? 7.29126   23.34947  -3.84335  1.000 35.08098  ? 158 PHE A N   1 
ATOM   1168 C CA  . PHE A 1 158 ? 6.51267   24.18679  -4.74652  1.000 35.09601  ? 158 PHE A CA  1 
ATOM   1169 C C   . PHE A 1 158 ? 7.34580   24.88216  -5.81849  1.000 38.81520  ? 158 PHE A C   1 
ATOM   1170 O O   . PHE A 1 158 ? 6.76862   25.48049  -6.73368  1.000 38.66471  ? 158 PHE A O   1 
ATOM   1171 C CB  . PHE A 1 158 ? 5.71215   25.20271  -3.92964  1.000 36.70338  ? 158 PHE A CB  1 
ATOM   1172 C CG  . PHE A 1 158 ? 4.65164   24.56667  -3.07306  1.000 35.72771  ? 158 PHE A CG  1 
ATOM   1173 C CD1 . PHE A 1 158 ? 3.39549   24.29274  -3.59526  1.000 32.31678  ? 158 PHE A CD1 1 
ATOM   1174 C CD2 . PHE A 1 158 ? 4.92025   24.20529  -1.76069  1.000 32.75466  ? 158 PHE A CD2 1 
ATOM   1175 C CE1 . PHE A 1 158 ? 2.41630   23.68998  -2.81957  1.000 34.42175  ? 158 PHE A CE1 1 
ATOM   1176 C CE2 . PHE A 1 158 ? 3.94791   23.60857  -0.97779  1.000 30.59392  ? 158 PHE A CE2 1 
ATOM   1177 C CZ  . PHE A 1 158 ? 2.68993   23.34700  -1.50759  1.000 31.69257  ? 158 PHE A CZ  1 
ATOM   1178 N N   . CYS A 1 159 ? 8.67573   24.79720  -5.75448  1.000 37.45631  ? 159 CYS A N   1 
ATOM   1179 C CA  . CYS A 1 159 ? 9.55815   25.24282  -6.83256  1.000 42.52545  ? 159 CYS A CA  1 
ATOM   1180 C C   . CYS A 1 159 ? 10.43013  24.07240  -7.27803  1.000 45.04932  ? 159 CYS A C   1 
ATOM   1181 O O   . CYS A 1 159 ? 11.63578  24.03725  -6.99368  1.000 51.01715  ? 159 CYS A O   1 
ATOM   1182 C CB  . CYS A 1 159 ? 10.41917  26.42840  -6.40080  1.000 48.85709  ? 159 CYS A CB  1 
ATOM   1183 S SG  . CYS A 1 159 ? 9.49084   27.92798  -6.09645  1.000 52.46505  ? 159 CYS A SG  1 
ATOM   1184 N N   . PRO A 1 160 ? 9.85291   23.10362  -7.99267  1.000 47.45638  ? 160 PRO A N   1 
ATOM   1185 C CA  . PRO A 1 160 ? 10.62294  21.91432  -8.39123  1.000 50.46353  ? 160 PRO A CA  1 
ATOM   1186 C C   . PRO A 1 160 ? 11.69989  22.26970  -9.40486  1.000 53.38274  ? 160 PRO A C   1 
ATOM   1187 O O   . PRO A 1 160 ? 11.44137  22.96789  -10.38743 1.000 56.49036  ? 160 PRO A O   1 
ATOM   1188 C CB  . PRO A 1 160 ? 9.56372   20.98876  -9.00743  1.000 45.78238  ? 160 PRO A CB  1 
ATOM   1189 C CG  . PRO A 1 160 ? 8.23476   21.60608  -8.66953  1.000 44.81653  ? 160 PRO A CG  1 
ATOM   1190 C CD  . PRO A 1 160 ? 8.47219   23.05919  -8.49638  1.000 39.37649  ? 160 PRO A CD  1 
ATOM   1191 N N   . ASN A 1 161 ? 12.90929  21.76896  -9.16424  1.000 58.32795  ? 161 ASN A N   1 
ATOM   1192 C CA  . ASN A 1 161 ? 14.05217  22.03061  -10.03868 1.000 72.76307  ? 161 ASN A CA  1 
ATOM   1193 C C   . ASN A 1 161 ? 13.93467  21.12576  -11.26195 1.000 75.39038  ? 161 ASN A C   1 
ATOM   1194 O O   . ASN A 1 161 ? 14.52489  20.04612  -11.34125 1.000 79.92640  ? 161 ASN A O   1 
ATOM   1195 C CB  . ASN A 1 161 ? 15.36133  21.80165  -9.29485  1.000 74.14220  ? 161 ASN A CB  1 
ATOM   1196 C CG  . ASN A 1 161 ? 15.28571  22.22039  -7.83892  1.000 79.04779  ? 161 ASN A CG  1 
ATOM   1197 O OD1 . ASN A 1 161 ? 14.74208  23.27740  -7.51004  1.000 71.64165  ? 161 ASN A OD1 1 
ATOM   1198 N ND2 . ASN A 1 161 ? 15.82212  21.38258  -6.95390  1.000 78.07363  ? 161 ASN A ND2 1 
ATOM   1199 N N   . THR A 1 162 ? 13.15940  21.58838  -12.23867 1.000 78.79355  ? 162 THR A N   1 
ATOM   1200 C CA  . THR A 1 162 ? 12.88705  20.81872  -13.45162 1.000 87.68223  ? 162 THR A CA  1 
ATOM   1201 C C   . THR A 1 162 ? 14.11729  20.64116  -14.34254 1.000 90.03762  ? 162 THR A C   1 
ATOM   1202 O O   . THR A 1 162 ? 15.25259  20.82393  -13.90369 1.000 93.38580  ? 162 THR A O   1 
ATOM   1203 C CB  . THR A 1 162 ? 11.77323  21.47878  -14.28465 1.000 84.79358  ? 162 THR A CB  1 
ATOM   1204 O OG1 . THR A 1 162 ? 11.48863  20.67093  -15.43323 1.000 83.27358  ? 162 THR A OG1 1 
ATOM   1205 C CG2 . THR A 1 162 ? 12.19530  22.86618  -14.73700 1.000 83.56741  ? 162 THR A CG2 1 
ATOM   1206 N N   . GLN A 1 172 ? 18.97971  24.66429  -7.85712  1.000 81.24136  ? 172 GLN A N   1 
ATOM   1207 C CA  . GLN A 1 172 ? 17.57607  24.90707  -8.17108  1.000 79.46989  ? 172 GLN A CA  1 
ATOM   1208 C C   . GLN A 1 172 ? 17.39104  25.49678  -9.56836  1.000 85.44146  ? 172 GLN A C   1 
ATOM   1209 O O   . GLN A 1 172 ? 18.02589  26.49063  -9.92392  1.000 83.63734  ? 172 GLN A O   1 
ATOM   1210 C CB  . GLN A 1 172 ? 16.94950  25.83574  -7.12793  1.000 73.10338  ? 172 GLN A CB  1 
ATOM   1211 C CG  . GLN A 1 172 ? 15.62606  26.45051  -7.56596  1.000 77.63514  ? 172 GLN A CG  1 
ATOM   1212 C CD  . GLN A 1 172 ? 14.68625  26.71831  -6.40437  1.000 78.47294  ? 172 GLN A CD  1 
ATOM   1213 O OE1 . GLN A 1 172 ? 14.91440  27.61813  -5.59136  1.000 69.85667  ? 172 GLN A OE1 1 
ATOM   1214 N NE2 . GLN A 1 172 ? 13.62180  25.92956  -6.31888  1.000 68.25798  ? 172 GLN A NE2 1 
ATOM   1215 N N   . SER A 1 173 ? 16.51441  24.87021  -10.35643 1.000 89.23466  ? 173 SER A N   1 
ATOM   1216 C CA  . SER A 1 173 ? 16.15245  25.36234  -11.67831 1.000 88.49293  ? 173 SER A CA  1 
ATOM   1217 C C   . SER A 1 173 ? 14.67510  25.71321  -11.79709 1.000 84.88258  ? 173 SER A C   1 
ATOM   1218 O O   . SER A 1 173 ? 14.23948  26.13695  -12.87458 1.000 83.51617  ? 173 SER A O   1 
ATOM   1219 C CB  . SER A 1 173 ? 16.52411  24.33086  -12.75382 1.000 86.41129  ? 173 SER A CB  1 
ATOM   1220 O OG  . SER A 1 173 ? 16.16844  24.78826  -14.04764 1.000 91.63413  ? 173 SER A OG  1 
ATOM   1221 N N   . GLY A 1 174 ? 13.89445  25.54776  -10.73021 1.000 79.56856  ? 174 GLY A N   1 
ATOM   1222 C CA  . GLY A 1 174 ? 12.49452  25.93050  -10.74231 1.000 72.22495  ? 174 GLY A CA  1 
ATOM   1223 C C   . GLY A 1 174 ? 12.33819  27.39145  -10.37412 1.000 67.41944  ? 174 GLY A C   1 
ATOM   1224 O O   . GLY A 1 174 ? 12.83690  27.83758  -9.33747  1.000 67.55546  ? 174 GLY A O   1 
ATOM   1225 N N   . LYS A 1 175 ? 11.64435  28.13542  -11.22997 1.000 70.01946  ? 175 LYS A N   1 
ATOM   1226 C CA  . LYS A 1 175 ? 11.52873  29.57348  -11.04886 1.000 60.82897  ? 175 LYS A CA  1 
ATOM   1227 C C   . LYS A 1 175 ? 10.46901  29.90210  -10.00552 1.000 61.43309  ? 175 LYS A C   1 
ATOM   1228 O O   . LYS A 1 175 ? 9.35221   29.37458  -10.04184 1.000 54.91444  ? 175 LYS A O   1 
ATOM   1229 C CB  . LYS A 1 175 ? 11.20449  30.25884  -12.37450 1.000 62.65402  ? 175 LYS A CB  1 
ATOM   1230 C CG  . LYS A 1 175 ? 12.31726  30.15196  -13.40569 1.000 71.18697  ? 175 LYS A CG  1 
ATOM   1231 C CD  . LYS A 1 175 ? 12.05561  31.05471  -14.60187 1.000 71.15244  ? 175 LYS A CD  1 
ATOM   1232 C CE  . LYS A 1 175 ? 10.63960  30.87180  -15.13722 1.000 76.38452  ? 175 LYS A CE  1 
ATOM   1233 N NZ  . LYS A 1 175 ? 10.34496  29.46157  -15.53437 1.000 73.77215  ? 175 LYS A NZ  1 
ATOM   1234 N N   . PHE A 1 176 ? 10.83795  30.77685  -9.07423  1.000 57.92346  ? 176 PHE A N   1 
ATOM   1235 C CA  . PHE A 1 176 ? 9.94668   31.28203  -8.03686  1.000 48.14642  ? 176 PHE A CA  1 
ATOM   1236 C C   . PHE A 1 176 ? 9.16491   32.45705  -8.61358  1.000 50.68609  ? 176 PHE A C   1 
ATOM   1237 O O   . PHE A 1 176 ? 9.73120   33.52944  -8.85137  1.000 48.38049  ? 176 PHE A O   1 
ATOM   1238 C CB  . PHE A 1 176 ? 10.78600  31.68528  -6.82815  1.000 46.02150  ? 176 PHE A CB  1 
ATOM   1239 C CG  . PHE A 1 176 ? 10.00912  32.27991  -5.69339  1.000 43.91554  ? 176 PHE A CG  1 
ATOM   1240 C CD1 . PHE A 1 176 ? 9.42361   31.46800  -4.73748  1.000 38.01625  ? 176 PHE A CD1 1 
ATOM   1241 C CD2 . PHE A 1 176 ? 9.92303   33.65624  -5.54456  1.000 43.41605  ? 176 PHE A CD2 1 
ATOM   1242 C CE1 . PHE A 1 176 ? 8.73172   32.01251  -3.67598  1.000 37.57353  ? 176 PHE A CE1 1 
ATOM   1243 C CE2 . PHE A 1 176 ? 9.23658   34.21015  -4.48228  1.000 40.50341  ? 176 PHE A CE2 1 
ATOM   1244 C CZ  . PHE A 1 176 ? 8.64202   33.38862  -3.54475  1.000 41.58395  ? 176 PHE A CZ  1 
ATOM   1245 N N   . LEU A 1 177 ? 7.87627   32.26054  -8.86584  1.000 44.38136  ? 177 LEU A N   1 
ATOM   1246 C CA  . LEU A 1 177 ? 7.06921   33.27026  -9.53471  1.000 44.91161  ? 177 LEU A CA  1 
ATOM   1247 C C   . LEU A 1 177 ? 6.00993   33.81883  -8.58636  1.000 40.62599  ? 177 LEU A C   1 
ATOM   1248 O O   . LEU A 1 177 ? 5.95369   33.47449  -7.40210  1.000 42.17664  ? 177 LEU A O   1 
ATOM   1249 C CB  . LEU A 1 177 ? 6.44261   32.70121  -10.81067 1.000 53.68379  ? 177 LEU A CB  1 
ATOM   1250 C CG  . LEU A 1 177 ? 7.45137   32.29865  -11.89476 1.000 57.40163  ? 177 LEU A CG  1 
ATOM   1251 C CD1 . LEU A 1 177 ? 6.73826   31.78568  -13.14278 1.000 63.59774  ? 177 LEU A CD1 1 
ATOM   1252 C CD2 . LEU A 1 177 ? 8.37093   33.46398  -12.24378 1.000 54.92232  ? 177 LEU A CD2 1 
ATOM   1253 N N   . LYS A 1 178 ? 5.15767   34.68760  -9.13559  1.000 42.27533  ? 178 LYS A N   1 
ATOM   1254 C CA  . LYS A 1 178 ? 4.22138   35.45085  -8.31914  1.000 43.44709  ? 178 LYS A CA  1 
ATOM   1255 C C   . LYS A 1 178 ? 3.28203   34.54050  -7.53762  1.000 42.80757  ? 178 LYS A C   1 
ATOM   1256 O O   . LYS A 1 178 ? 2.95496   34.82384  -6.37880  1.000 38.85699  ? 178 LYS A O   1 
ATOM   1257 C CB  . LYS A 1 178 ? 3.43386   36.41080  -9.21119  1.000 46.45381  ? 178 LYS A CB  1 
ATOM   1258 C CG  . LYS A 1 178 ? 2.34943   37.20012  -8.50637  1.000 49.76574  ? 178 LYS A CG  1 
ATOM   1259 C CD  . LYS A 1 178 ? 2.92312   38.15587  -7.47125  1.000 55.13708  ? 178 LYS A CD  1 
ATOM   1260 C CE  . LYS A 1 178 ? 1.82786   39.05851  -6.91239  1.000 58.75530  ? 178 LYS A CE  1 
ATOM   1261 N NZ  . LYS A 1 178 ? 2.28383   39.86020  -5.74207  1.000 59.65286  ? 178 LYS A NZ  1 
ATOM   1262 N N   . SER A 1 179 ? 2.84890   33.43515  -8.14484  1.000 41.76268  ? 179 SER A N   1 
ATOM   1263 C CA  . SER A 1 179 ? 1.93022   32.53042  -7.45914  1.000 51.15789  ? 179 SER A CA  1 
ATOM   1264 C C   . SER A 1 179 ? 2.58160   31.91593  -6.22555  1.000 40.44007  ? 179 SER A C   1 
ATOM   1265 O O   . SER A 1 179 ? 1.97932   31.88003  -5.14555  1.000 36.92232  ? 179 SER A O   1 
ATOM   1266 C CB  . SER A 1 179 ? 1.45203   31.43960  -8.41805  1.000 50.17916  ? 179 SER A CB  1 
ATOM   1267 O OG  . SER A 1 179 ? 2.53560   30.63027  -8.83400  1.000 58.86721  ? 179 SER A OG  1 
ATOM   1268 N N   . GLN A 1 180 ? 3.81725   31.42503  -6.36652  1.000 39.62823  ? 180 GLN A N   1 
ATOM   1269 C CA  . GLN A 1 180 ? 4.52523   30.88539  -5.20956  1.000 41.89291  ? 180 GLN A CA  1 
ATOM   1270 C C   . GLN A 1 180 ? 4.79151   31.96969  -4.17355  1.000 38.87363  ? 180 GLN A C   1 
ATOM   1271 O O   . GLN A 1 180 ? 4.72888   31.71016  -2.96530  1.000 40.94999  ? 180 GLN A O   1 
ATOM   1272 C CB  . GLN A 1 180 ? 5.84159   30.23078  -5.63729  1.000 42.82161  ? 180 GLN A CB  1 
ATOM   1273 C CG  . GLN A 1 180 ? 5.69252   28.94889  -6.43810  1.000 38.73777  ? 180 GLN A CG  1 
ATOM   1274 C CD  . GLN A 1 180 ? 6.03107   29.14184  -7.89630  1.000 50.28127  ? 180 GLN A CD  1 
ATOM   1275 O OE1 . GLN A 1 180 ? 5.63802   30.13438  -8.50882  1.000 53.52571  ? 180 GLN A OE1 1 
ATOM   1276 N NE2 . GLN A 1 180 ? 6.77667   28.19758  -8.46274  1.000 55.76430  ? 180 GLN A NE2 1 
ATOM   1277 N N   . ALA A 1 181 ? 5.09363   33.18841  -4.62860  1.000 37.52091  ? 181 ALA A N   1 
ATOM   1278 C CA  . ALA A 1 181 ? 5.37221   34.28024  -3.70048  1.000 38.65032  ? 181 ALA A CA  1 
ATOM   1279 C C   . ALA A 1 181 ? 4.16156   34.59655  -2.83676  1.000 35.21183  ? 181 ALA A C   1 
ATOM   1280 O O   . ALA A 1 181 ? 4.30429   34.89805  -1.64558  1.000 36.31882  ? 181 ALA A O   1 
ATOM   1281 C CB  . ALA A 1 181 ? 5.82540   35.52342  -4.46877  1.000 35.86573  ? 181 ALA A CB  1 
ATOM   1282 N N   . ILE A 1 182 ? 2.96026   34.52820  -3.41492  1.000 38.50690  ? 182 ILE A N   1 
ATOM   1283 C CA  . ILE A 1 182 ? 1.74730   34.79748  -2.64478  1.000 38.76556  ? 182 ILE A CA  1 
ATOM   1284 C C   . ILE A 1 182 ? 1.51904   33.69907  -1.61667  1.000 35.56819  ? 182 ILE A C   1 
ATOM   1285 O O   . ILE A 1 182 ? 1.25419   33.96902  -0.43996  1.000 34.65946  ? 182 ILE A O   1 
ATOM   1286 C CB  . ILE A 1 182 ? 0.53518   34.94194  -3.58264  1.000 40.61293  ? 182 ILE A CB  1 
ATOM   1287 C CG1 . ILE A 1 182 ? 0.61993   36.24139  -4.38562  1.000 47.20677  ? 182 ILE A CG1 1 
ATOM   1288 C CG2 . ILE A 1 182 ? -0.76832  34.88564  -2.79417  1.000 41.81299  ? 182 ILE A CG2 1 
ATOM   1289 C CD1 . ILE A 1 182 ? -0.44648  36.35653  -5.45314  1.000 47.28601  ? 182 ILE A CD1 1 
ATOM   1290 N N   . LEU A 1 183 ? 1.60346   32.44266  -2.05319  1.000 36.17019  ? 183 LEU A N   1 
ATOM   1291 C CA  . LEU A 1 183 ? 1.42164   31.32139  -1.13809  1.000 36.40278  ? 183 LEU A CA  1 
ATOM   1292 C C   . LEU A 1 183 ? 2.47806   31.32690  -0.04174  1.000 33.05796  ? 183 LEU A C   1 
ATOM   1293 O O   . LEU A 1 183 ? 2.16861   31.09171  1.13214   1.000 33.72121  ? 183 LEU A O   1 
ATOM   1294 C CB  . LEU A 1 183 ? 1.46695   30.00726  -1.91724  1.000 32.98265  ? 183 LEU A CB  1 
ATOM   1295 C CG  . LEU A 1 183 ? 1.32450   28.73699  -1.08389  1.000 35.58772  ? 183 LEU A CG  1 
ATOM   1296 C CD1 . LEU A 1 183 ? -0.01497  28.72079  -0.38196  1.000 33.24977  ? 183 LEU A CD1 1 
ATOM   1297 C CD2 . LEU A 1 183 ? 1.49956   27.49700  -1.95925  1.000 37.53406  ? 183 LEU A CD2 1 
ATOM   1298 N N   . TYR A 1 184 ? 3.73230   31.59671  -0.40754  1.000 33.17797  ? 184 TYR A N   1 
ATOM   1299 C CA  . TYR A 1 184 ? 4.81532   31.56266  0.57016   1.000 34.23244  ? 184 TYR A CA  1 
ATOM   1300 C C   . TYR A 1 184 ? 4.59860   32.60138  1.66291   1.000 35.46555  ? 184 TYR A C   1 
ATOM   1301 O O   . TYR A 1 184 ? 4.78608   32.31478  2.85266   1.000 36.15625  ? 184 TYR A O   1 
ATOM   1302 C CB  . TYR A 1 184 ? 6.14927   31.79412  -0.13820  1.000 31.07607  ? 184 TYR A CB  1 
ATOM   1303 C CG  . TYR A 1 184 ? 7.35879   31.24507  0.58054   1.000 34.55496  ? 184 TYR A CG  1 
ATOM   1304 C CD1 . TYR A 1 184 ? 7.22699   30.48859  1.73880   1.000 38.08255  ? 184 TYR A CD1 1 
ATOM   1305 C CD2 . TYR A 1 184 ? 8.63976   31.48375  0.09502   1.000 36.22350  ? 184 TYR A CD2 1 
ATOM   1306 C CE1 . TYR A 1 184 ? 8.34211   29.98417  2.39023   1.000 41.71554  ? 184 TYR A CE1 1 
ATOM   1307 C CE2 . TYR A 1 184 ? 9.75672   30.99148  0.74274   1.000 37.39112  ? 184 TYR A CE2 1 
ATOM   1308 C CZ  . TYR A 1 184 ? 9.60148   30.24580  1.88456   1.000 38.21437  ? 184 TYR A CZ  1 
ATOM   1309 O OH  . TYR A 1 184 ? 10.71339  29.76006  2.51925   1.000 45.75129  ? 184 TYR A OH  1 
ATOM   1310 N N   . LEU A 1 185 ? 4.19307   33.81481  1.27905   1.000 29.86544  ? 185 LEU A N   1 
ATOM   1311 C CA  . LEU A 1 185 ? 3.98868   34.86596  2.26898   1.000 29.30834  ? 185 LEU A CA  1 
ATOM   1312 C C   . LEU A 1 185 ? 2.87282   34.49852  3.23843   1.000 29.83369  ? 185 LEU A C   1 
ATOM   1313 O O   . LEU A 1 185 ? 3.01046   34.68979  4.45168   1.000 38.45619  ? 185 LEU A O   1 
ATOM   1314 C CB  . LEU A 1 185 ? 3.69008   36.19457  1.56952   1.000 33.96764  ? 185 LEU A CB  1 
ATOM   1315 C CG  . LEU A 1 185 ? 3.42415   37.40768  2.46739   1.000 40.22330  ? 185 LEU A CG  1 
ATOM   1316 C CD1 . LEU A 1 185 ? 4.58339   37.63094  3.43237   1.000 37.86421  ? 185 LEU A CD1 1 
ATOM   1317 C CD2 . LEU A 1 185 ? 3.17613   38.65805  1.62049   1.000 36.69551  ? 185 LEU A CD2 1 
ATOM   1318 N N   . ASP A 1 186 ? 1.75988   33.96544  2.72460   1.000 37.60056  ? 186 ASP A N   1 
ATOM   1319 C CA  . ASP A 1 186 ? 0.69342   33.49577  3.60480   1.000 35.59603  ? 186 ASP A CA  1 
ATOM   1320 C C   . ASP A 1 186 ? 1.19507   32.40044  4.53348   1.000 34.85826  ? 186 ASP A C   1 
ATOM   1321 O O   . ASP A 1 186 ? 0.83875   32.36733  5.71800   1.000 34.39867  ? 186 ASP A O   1 
ATOM   1322 C CB  . ASP A 1 186 ? -0.48892  32.97952  2.78717   1.000 39.28161  ? 186 ASP A CB  1 
ATOM   1323 C CG  . ASP A 1 186 ? -1.32508  34.09117  2.19675   1.000 55.75738  ? 186 ASP A CG  1 
ATOM   1324 O OD1 . ASP A 1 186 ? -1.11645  34.42225  1.01117   1.000 52.66535  ? 186 ASP A OD1 1 
ATOM   1325 O OD2 . ASP A 1 186 ? -2.19435  34.63030  2.91653   1.000 58.58178  ? 186 ASP A OD2 1 
ATOM   1326 N N   . LEU A 1 187 ? 2.01752   31.48965  4.00638   1.000 33.30057  ? 187 LEU A N   1 
ATOM   1327 C CA  . LEU A 1 187 ? 2.56636   30.41121  4.82450   1.000 32.32608  ? 187 LEU A CA  1 
ATOM   1328 C C   . LEU A 1 187 ? 3.43408   30.96213  5.94503   1.000 34.94946  ? 187 LEU A C   1 
ATOM   1329 O O   . LEU A 1 187 ? 3.27970   30.57886  7.10997   1.000 36.90879  ? 187 LEU A O   1 
ATOM   1330 C CB  . LEU A 1 187 ? 3.37795   29.44924  3.95960   1.000 32.20373  ? 187 LEU A CB  1 
ATOM   1331 C CG  . LEU A 1 187 ? 4.16134   28.44187  4.80660   1.000 35.86637  ? 187 LEU A CG  1 
ATOM   1332 C CD1 . LEU A 1 187 ? 3.21863   27.46604  5.48735   1.000 35.03312  ? 187 LEU A CD1 1 
ATOM   1333 C CD2 . LEU A 1 187 ? 5.21037   27.72406  3.98190   1.000 37.53962  ? 187 LEU A CD2 1 
ATOM   1334 N N   . LYS A 1 188 ? 4.36640   31.85687  5.60355   1.000 36.61823  ? 188 LYS A N   1 
ATOM   1335 C CA  . LYS A 1 188 ? 5.21566   32.47235  6.61889   1.000 35.83749  ? 188 LYS A CA  1 
ATOM   1336 C C   . LYS A 1 188 ? 4.38056   33.17388  7.68183   1.000 37.99023  ? 188 LYS A C   1 
ATOM   1337 O O   . LYS A 1 188 ? 4.68881   33.09895  8.87735   1.000 42.40669  ? 188 LYS A O   1 
ATOM   1338 C CB  . LYS A 1 188 ? 6.18384   33.45542  5.96198   1.000 33.28698  ? 188 LYS A CB  1 
ATOM   1339 C CG  . LYS A 1 188 ? 7.32964   32.80700  5.19283   1.000 40.46170  ? 188 LYS A CG  1 
ATOM   1340 C CD  . LYS A 1 188 ? 8.32926   33.86707  4.73575   1.000 42.18368  ? 188 LYS A CD  1 
ATOM   1341 C CE  . LYS A 1 188 ? 9.59502   33.25299  4.15587   1.000 41.99491  ? 188 LYS A CE  1 
ATOM   1342 N NZ  . LYS A 1 188 ? 10.49495  32.71799  5.20776   1.000 43.02046  ? 188 LYS A NZ  1 
ATOM   1343 N N   . THR A 1 189 ? 3.30808   33.84977  7.26433   1.000 40.44490  ? 189 THR A N   1 
ATOM   1344 C CA  . THR A 1 189 ? 2.45420   34.54736  8.21859   1.000 39.13296  ? 189 THR A CA  1 
ATOM   1345 C C   . THR A 1 189 ? 1.72692   33.56487  9.12963   1.000 40.11661  ? 189 THR A C   1 
ATOM   1346 O O   . THR A 1 189 ? 1.61843   33.80051  10.33832  1.000 40.76652  ? 189 THR A O   1 
ATOM   1347 C CB  . THR A 1 189 ? 1.46594   35.44237  7.46788   1.000 44.08485  ? 189 THR A CB  1 
ATOM   1348 O OG1 . THR A 1 189 ? 2.19386   36.40913  6.70047   1.000 37.89283  ? 189 THR A OG1 1 
ATOM   1349 C CG2 . THR A 1 189 ? 0.53539   36.16491  8.43458   1.000 43.42683  ? 189 THR A CG2 1 
ATOM   1350 N N   . GLN A 1 190 ? 1.23250   32.45060  8.57483   1.000 42.26360  ? 190 GLN A N   1 
ATOM   1351 C CA  . GLN A 1 190 ? 0.60237   31.42685  9.40957   1.000 41.13442  ? 190 GLN A CA  1 
ATOM   1352 C C   . GLN A 1 190 ? 1.60133   30.76535  10.35368  1.000 41.00330  ? 190 GLN A C   1 
ATOM   1353 O O   . GLN A 1 190 ? 1.22252   30.34322  11.45255  1.000 43.94742  ? 190 GLN A O   1 
ATOM   1354 C CB  . GLN A 1 190 ? -0.06874  30.36202  8.54179   1.000 37.29070  ? 190 GLN A CB  1 
ATOM   1355 C CG  . GLN A 1 190 ? -1.36394  30.80709  7.88876   1.000 43.01838  ? 190 GLN A CG  1 
ATOM   1356 C CD  . GLN A 1 190 ? -2.44460  31.15405  8.89824   1.000 43.13727  ? 190 GLN A CD  1 
ATOM   1357 O OE1 . GLN A 1 190 ? -2.54418  30.54059  9.96299   1.000 43.35332  ? 190 GLN A OE1 1 
ATOM   1358 N NE2 . GLN A 1 190 ? -3.25870  32.14869  8.56680   1.000 40.74393  ? 190 GLN A NE2 1 
ATOM   1359 N N   . ALA A 1 191 ? 2.86653   30.64945  9.94412   1.000 37.31302  ? 191 ALA A N   1 
ATOM   1360 C CA  . ALA A 1 191 ? 3.87868   30.08481  10.83025  1.000 41.53513  ? 191 ALA A CA  1 
ATOM   1361 C C   . ALA A 1 191 ? 4.14463   30.99031  12.02222  1.000 48.36743  ? 191 ALA A C   1 
ATOM   1362 O O   . ALA A 1 191 ? 4.42368   30.50167  13.12372  1.000 47.17892  ? 191 ALA A O   1 
ATOM   1363 C CB  . ALA A 1 191 ? 5.17229   29.82991  10.05662  1.000 39.33650  ? 191 ALA A CB  1 
ATOM   1364 N N   . TYR A 1 192 ? 4.07020   32.30683  11.81918  1.000 47.34998  ? 192 TYR A N   1 
ATOM   1365 C CA  . TYR A 1 192 ? 4.18866   33.24382  12.93001  1.000 46.29155  ? 192 TYR A CA  1 
ATOM   1366 C C   . TYR A 1 192 ? 2.99668   33.12103  13.86932  1.000 45.68623  ? 192 TYR A C   1 
ATOM   1367 O O   . TYR A 1 192 ? 3.16295   33.05360  15.09271  1.000 53.92214  ? 192 TYR A O   1 
ATOM   1368 C CB  . TYR A 1 192 ? 4.32365   34.66781  12.38462  1.000 44.52418  ? 192 TYR A CB  1 
ATOM   1369 C CG  . TYR A 1 192 ? 4.27136   35.76174  13.42654  1.000 45.77740  ? 192 TYR A CG  1 
ATOM   1370 C CD1 . TYR A 1 192 ? 5.37806   36.05526  14.21062  1.000 49.72526  ? 192 TYR A CD1 1 
ATOM   1371 C CD2 . TYR A 1 192 ? 3.11723   36.51318  13.61196  1.000 49.40555  ? 192 TYR A CD2 1 
ATOM   1372 C CE1 . TYR A 1 192 ? 5.33436   37.06163  15.15836  1.000 55.71401  ? 192 TYR A CE1 1 
ATOM   1373 C CE2 . TYR A 1 192 ? 3.06338   37.52075  14.55415  1.000 53.09546  ? 192 TYR A CE2 1 
ATOM   1374 C CZ  . TYR A 1 192 ? 4.17384   37.79079  15.32543  1.000 59.07578  ? 192 TYR A CZ  1 
ATOM   1375 O OH  . TYR A 1 192 ? 4.11935   38.79587  16.26483  1.000 60.91286  ? 192 TYR A OH  1 
ATOM   1376 N N   . ILE A 1 193 ? 1.78388   33.07933  13.30984  1.000 42.13063  ? 193 ILE A N   1 
ATOM   1377 C CA  . ILE A 1 193 ? 0.58339   32.89689  14.12221  1.000 46.69009  ? 193 ILE A CA  1 
ATOM   1378 C C   . ILE A 1 193 ? 0.64278   31.57395  14.87621  1.000 52.74342  ? 193 ILE A C   1 
ATOM   1379 O O   . ILE A 1 193 ? 0.29245   31.49968  16.06054  1.000 52.35797  ? 193 ILE A O   1 
ATOM   1380 C CB  . ILE A 1 193 ? -0.67475  32.98321  13.23775  1.000 49.33501  ? 193 ILE A CB  1 
ATOM   1381 C CG1 . ILE A 1 193 ? -0.78915  34.36507  12.58990  1.000 46.47637  ? 193 ILE A CG1 1 
ATOM   1382 C CG2 . ILE A 1 193 ? -1.92697  32.66611  14.04165  1.000 48.61278  ? 193 ILE A CG2 1 
ATOM   1383 C CD1 . ILE A 1 193 ? -2.00622  34.50929  11.70249  1.000 40.15807  ? 193 ILE A CD1 1 
ATOM   1384 N N   . ALA A 1 194 ? 1.08609   30.50901  14.20372  1.000 48.66758  ? 194 ALA A N   1 
ATOM   1385 C CA  . ALA A 1 194 ? 1.18754   29.21176  14.86275  1.000 52.91525  ? 194 ALA A CA  1 
ATOM   1386 C C   . ALA A 1 194 ? 2.26157   29.22622  15.94131  1.000 57.52285  ? 194 ALA A C   1 
ATOM   1387 O O   . ALA A 1 194 ? 2.08222   28.63121  17.01047  1.000 63.15055  ? 194 ALA A O   1 
ATOM   1388 C CB  . ALA A 1 194 ? 1.47336   28.11783  13.83540  1.000 44.61239  ? 194 ALA A CB  1 
ATOM   1389 N N   . GLY A 1 195 ? 3.38452   29.89733  15.67855  1.000 55.19459  ? 195 GLY A N   1 
ATOM   1390 C CA  . GLY A 1 195 ? 4.42006   30.00497  16.69131  1.000 53.15525  ? 195 GLY A CA  1 
ATOM   1391 C C   . GLY A 1 195 ? 3.94841   30.75617  17.92071  1.000 58.52710  ? 195 GLY A C   1 
ATOM   1392 O O   . GLY A 1 195 ? 4.30226   30.40590  19.04897  1.000 60.42609  ? 195 GLY A O   1 
ATOM   1393 N N   . LEU A 1 196 ? 3.14224   31.80085  17.71980  1.000 60.70785  ? 196 LEU A N   1 
ATOM   1394 C CA  . LEU A 1 196 ? 2.57712   32.52431  18.85334  1.000 64.18100  ? 196 LEU A CA  1 
ATOM   1395 C C   . LEU A 1 196 ? 1.50890   31.69611  19.55674  1.000 69.83789  ? 196 LEU A C   1 
ATOM   1396 O O   . LEU A 1 196 ? 1.54929   31.53068  20.78198  1.000 74.23956  ? 196 LEU A O   1 
ATOM   1397 C CB  . LEU A 1 196 ? 1.99378   33.85851  18.39327  1.000 60.41357  ? 196 LEU A CB  1 
ATOM   1398 C CG  . LEU A 1 196 ? 2.96529   34.92620  17.90153  1.000 55.32594  ? 196 LEU A CG  1 
ATOM   1399 C CD1 . LEU A 1 196 ? 2.21733   36.22774  17.73937  1.000 56.36097  ? 196 LEU A CD1 1 
ATOM   1400 C CD2 . LEU A 1 196 ? 4.11466   35.09050  18.88023  1.000 62.66541  ? 196 LEU A CD2 1 
ATOM   1401 N N   . LYS A 1 197 ? 0.54155   31.17025  18.79028  1.000 66.28750  ? 197 LYS A N   1 
ATOM   1402 C CA  . LYS A 1 197 ? -0.57176  30.41298  19.36339  1.000 70.01827  ? 197 LYS A CA  1 
ATOM   1403 C C   . LYS A 1 197 ? -0.09402  29.31799  20.30606  1.000 62.24733  ? 197 LYS A C   1 
ATOM   1404 O O   . LYS A 1 197 ? -0.77539  28.99850  21.28807  1.000 68.63037  ? 197 LYS A O   1 
ATOM   1405 C CB  . LYS A 1 197 ? -1.42505  29.80583  18.24406  1.000 61.34135  ? 197 LYS A CB  1 
ATOM   1406 C CG  . LYS A 1 197 ? -2.52437  28.87142  18.73416  1.000 65.73304  ? 197 LYS A CG  1 
ATOM   1407 C CD  . LYS A 1 197 ? -3.40974  28.37889  17.60358  1.000 70.04767  ? 197 LYS A CD  1 
ATOM   1408 C CE  . LYS A 1 197 ? -4.42769  27.36892  18.11693  1.000 79.86561  ? 197 LYS A CE  1 
ATOM   1409 N NZ  . LYS A 1 197 ? -5.52152  27.11453  17.13771  1.000 77.02775  ? 197 LYS A NZ  1 
ATOM   1410 N N   . GLU A 1 198 ? 1.07749   28.74551  20.02978  1.000 61.54061  ? 198 GLU A N   1 
ATOM   1411 C CA  . GLU A 1 198 ? 1.64254   27.72185  20.89952  1.000 64.04229  ? 198 GLU A CA  1 
ATOM   1412 C C   . GLU A 1 198 ? 1.84904   28.24941  22.31528  1.000 73.99500  ? 198 GLU A C   1 
ATOM   1413 O O   . GLU A 1 198 ? 1.43185   27.61760  23.29272  1.000 73.85658  ? 198 GLU A O   1 
ATOM   1414 C CB  . GLU A 1 198 ? 2.95946   27.23068  20.30580  1.000 64.84627  ? 198 GLU A CB  1 
ATOM   1415 C CG  . GLU A 1 198 ? 3.49384   25.96100  20.90426  1.000 66.92175  ? 198 GLU A CG  1 
ATOM   1416 C CD  . GLU A 1 198 ? 4.57662   25.35849  20.03998  1.000 81.78088  ? 198 GLU A CD  1 
ATOM   1417 O OE1 . GLU A 1 198 ? 5.65404   25.97797  19.91377  1.000 84.40006  ? 198 GLU A OE1 1 
ATOM   1418 O OE2 . GLU A 1 198 ? 4.33974   24.27815  19.46179  1.000 84.87568  ? 198 GLU A OE2 1 
ATOM   1419 N N   . PHE A 1 199 ? 2.48371   29.41682  22.44529  1.000 76.64790  ? 199 PHE A N   1 
ATOM   1420 C CA  . PHE A 1 199 ? 2.83349   29.98372  23.74339  1.000 74.04412  ? 199 PHE A CA  1 
ATOM   1421 C C   . PHE A 1 199 ? 1.91298   31.12930  24.15080  1.000 71.47695  ? 199 PHE A C   1 
ATOM   1422 O O   . PHE A 1 199 ? 2.32539   32.02223  24.89816  1.000 72.11352  ? 199 PHE A O   1 
ATOM   1423 C CB  . PHE A 1 199 ? 4.28923   30.44706  23.73986  1.000 68.06641  ? 199 PHE A CB  1 
ATOM   1424 C CG  . PHE A 1 199 ? 5.27647   29.32768  23.61952  1.000 65.91294  ? 199 PHE A CG  1 
ATOM   1425 C CD1 . PHE A 1 199 ? 5.69990   28.64066  24.74204  1.000 65.00017  ? 199 PHE A CD1 1 
ATOM   1426 C CD2 . PHE A 1 199 ? 5.77723   28.95799  22.38499  1.000 69.65612  ? 199 PHE A CD2 1 
ATOM   1427 C CE1 . PHE A 1 199 ? 6.61076   27.60853  24.63913  1.000 73.14897  ? 199 PHE A CE1 1 
ATOM   1428 C CE2 . PHE A 1 199 ? 6.68849   27.92514  22.27273  1.000 75.95665  ? 199 PHE A CE2 1 
ATOM   1429 C CZ  . PHE A 1 199 ? 7.10704   27.24896  23.40225  1.000 76.70835  ? 199 PHE A CZ  1 
ATOM   1430 N N   . GLN A 1 200 ? 0.67079   31.11932  23.67939  1.000 71.52046  ? 200 GLN A N   1 
ATOM   1431 C CA  . GLN A 1 200 ? -0.29401  32.15788  24.01150  1.000 80.19476  ? 200 GLN A CA  1 
ATOM   1432 C C   . GLN A 1 200 ? -1.15622  31.71371  25.18432  1.000 80.17198  ? 200 GLN A C   1 
ATOM   1433 O O   . GLN A 1 200 ? -1.65233  30.58214  25.20474  1.000 80.36170  ? 200 GLN A O   1 
ATOM   1434 C CB  . GLN A 1 200 ? -1.17735  32.49523  22.80950  1.000 76.23670  ? 200 GLN A CB  1 
ATOM   1435 C CG  . GLN A 1 200 ? -0.64411  33.64180  21.96465  1.000 78.53777  ? 200 GLN A CG  1 
ATOM   1436 C CD  . GLN A 1 200 ? -0.46134  34.91411  22.77125  1.000 78.51723  ? 200 GLN A CD  1 
ATOM   1437 O OE1 . GLN A 1 200 ? 0.65435   35.25949  23.16705  1.000 86.42931  ? 200 GLN A OE1 1 
ATOM   1438 N NE2 . GLN A 1 200 ? -1.56183  35.61382  23.02854  1.000 78.10219  ? 200 GLN A NE2 1 
ATOM   1439 N N   . ASP A 1 201 ? -1.33290  32.60788  26.15290  1.000 80.08694  ? 201 ASP A N   1 
ATOM   1440 C CA  . ASP A 1 201 ? -2.18751  32.34715  27.29706  1.000 83.50037  ? 201 ASP A CA  1 
ATOM   1441 C C   . ASP A 1 201 ? -3.62467  32.75067  26.97435  1.000 83.99448  ? 201 ASP A C   1 
ATOM   1442 O O   . ASP A 1 201 ? -3.95219  33.13940  25.84989  1.000 85.75703  ? 201 ASP A O   1 
ATOM   1443 C CB  . ASP A 1 201 ? -1.66916  33.08119  28.53412  1.000 81.51609  ? 201 ASP A CB  1 
ATOM   1444 C CG  . ASP A 1 201 ? -1.13197  34.46418  28.21312  1.000 79.93383  ? 201 ASP A CG  1 
ATOM   1445 O OD1 . ASP A 1 201 ? -1.75301  35.16729  27.38745  1.000 83.88067  ? 201 ASP A OD1 1 
ATOM   1446 O OD2 . ASP A 1 201 ? -0.09644  34.85250  28.79822  1.000 63.64780  ? 201 ASP A OD2 1 
ATOM   1447 N N   . GLU A 1 202 ? -4.49477  32.65636  27.98410  1.000 88.25496  ? 202 GLU A N   1 
ATOM   1448 C CA  . GLU A 1 202 ? -5.89187  33.04378  27.80830  1.000 85.68467  ? 202 GLU A CA  1 
ATOM   1449 C C   . GLU A 1 202 ? -6.01338  34.52606  27.48280  1.000 88.44166  ? 202 GLU A C   1 
ATOM   1450 O O   . GLU A 1 202 ? -6.88773  34.92985  26.70692  1.000 90.27987  ? 202 GLU A O   1 
ATOM   1451 C CB  . GLU A 1 202 ? -6.68663  32.70537  29.06775  1.000 94.59455  ? 202 GLU A CB  1 
ATOM   1452 C CG  . GLU A 1 202 ? -6.42877  31.30919  29.60351  1.000 91.62553  ? 202 GLU A CG  1 
ATOM   1453 C CD  . GLU A 1 202 ? -6.61663  31.23267  31.10408  1.000 94.64331  ? 202 GLU A CD  1 
ATOM   1454 O OE1 . GLU A 1 202 ? -5.90327  31.95826  31.83088  1.000 90.93176  ? 202 GLU A OE1 1 
ATOM   1455 O OE2 . GLU A 1 202 ? -7.48773  30.46220  31.55654  1.000 89.15089  ? 202 GLU A OE2 1 
ATOM   1456 N N   . THR A 1 203 ? -5.14791  35.35018  28.07074  1.000 86.95730  ? 203 THR A N   1 
ATOM   1457 C CA  . THR A 1 203 ? -5.08010  36.75592  27.70943  1.000 83.05084  ? 203 THR A CA  1 
ATOM   1458 C C   . THR A 1 203 ? -4.71008  36.89561  26.23651  1.000 83.26744  ? 203 THR A C   1 
ATOM   1459 O O   . THR A 1 203 ? -4.12003  35.99948  25.62667  1.000 84.06470  ? 203 THR A O   1 
ATOM   1460 C CB  . THR A 1 203 ? -4.05132  37.48651  28.57250  1.000 76.86418  ? 203 THR A CB  1 
ATOM   1461 O OG1 . THR A 1 203 ? -2.75278  37.36222  27.97814  1.000 79.61213  ? 203 THR A OG1 1 
ATOM   1462 C CG2 . THR A 1 203 ? -4.00904  36.88506  29.96692  1.000 81.04863  ? 203 THR A CG2 1 
ATOM   1463 N N   . ASN A 1 204 ? -5.07050  38.03659  25.65915  1.000 83.14953  ? 204 ASN A N   1 
ATOM   1464 C CA  . ASN A 1 204 ? -4.77582  38.30174  24.25912  1.000 83.97371  ? 204 ASN A CA  1 
ATOM   1465 C C   . ASN A 1 204 ? -3.43235  38.99071  24.05935  1.000 77.22233  ? 204 ASN A C   1 
ATOM   1466 O O   . ASN A 1 204 ? -3.09518  39.34598  22.92574  1.000 78.01754  ? 204 ASN A O   1 
ATOM   1467 C CB  . ASN A 1 204 ? -5.89096  39.14291  23.63602  1.000 80.18244  ? 204 ASN A CB  1 
ATOM   1468 C CG  . ASN A 1 204 ? -6.54027  38.45763  22.45274  1.000 82.72719  ? 204 ASN A CG  1 
ATOM   1469 O OD1 . ASN A 1 204 ? -5.89433  37.70030  21.72700  1.000 77.21725  ? 204 ASN A OD1 1 
ATOM   1470 N ND2 . ASN A 1 204 ? -7.82754  38.71682  22.25363  1.000 87.99507  ? 204 ASN A ND2 1 
ATOM   1471 N N   . GLU A 1 205 ? -2.65740  39.17497  25.12478  1.000 78.74189  ? 205 GLU A N   1 
ATOM   1472 C CA  . GLU A 1 205 ? -1.39523  39.89480  25.03217  1.000 76.22001  ? 205 GLU A CA  1 
ATOM   1473 C C   . GLU A 1 205 ? -0.30452  38.99235  24.47056  1.000 68.23335  ? 205 GLU A C   1 
ATOM   1474 O O   . GLU A 1 205 ? -0.12614  37.85729  24.92303  1.000 73.47619  ? 205 GLU A O   1 
ATOM   1475 C CB  . GLU A 1 205 ? -0.99731  40.43921  26.40237  1.000 83.38556  ? 205 GLU A CB  1 
ATOM   1476 C CG  . GLU A 1 205 ? -1.82988  41.64126  26.82808  1.000 90.68143  ? 205 GLU A CG  1 
ATOM   1477 C CD  . GLU A 1 205 ? -1.73228  41.93390  28.30974  1.000 94.84395  ? 205 GLU A CD  1 
ATOM   1478 O OE1 . GLU A 1 205 ? -1.27110  41.04915  29.06138  1.000 99.65981  ? 205 GLU A OE1 1 
ATOM   1479 O OE2 . GLU A 1 205 ? -2.12040  43.04874  28.72042  1.000 97.61028  ? 205 GLU A OE2 1 
ATOM   1480 N N   . ILE A 1 206 ? 0.41995   39.50301  23.48158  1.000 66.15931  ? 206 ILE A N   1 
ATOM   1481 C CA  . ILE A 1 206 ? 1.44563   38.73977  22.78117  1.000 70.56228  ? 206 ILE A CA  1 
ATOM   1482 C C   . ILE A 1 206 ? 2.77553   38.92457  23.49785  1.000 68.23773  ? 206 ILE A C   1 
ATOM   1483 O O   . ILE A 1 206 ? 3.19922   40.05754  23.75596  1.000 68.00782  ? 206 ILE A O   1 
ATOM   1484 C CB  . ILE A 1 206 ? 1.54695   39.17968  21.30993  1.000 71.31892  ? 206 ILE A CB  1 
ATOM   1485 C CG1 . ILE A 1 206 ? 0.23372   38.89845  20.57093  1.000 65.98098  ? 206 ILE A CG1 1 
ATOM   1486 C CG2 . ILE A 1 206 ? 2.72285   38.48955  20.62162  1.000 60.84898  ? 206 ILE A CG2 1 
ATOM   1487 C CD1 . ILE A 1 206 ? 0.18673   39.46386  19.16473  1.000 55.87859  ? 206 ILE A CD1 1 
ATOM   1488 N N   . SER A 1 207 ? 3.43407   37.81183  23.82111  1.000 70.53614  ? 207 SER A N   1 
ATOM   1489 C CA  . SER A 1 207 ? 4.75334   37.86877  24.44002  1.000 62.98271  ? 207 SER A CA  1 
ATOM   1490 C C   . SER A 1 207 ? 5.74530   38.54645  23.50587  1.000 63.70550  ? 207 SER A C   1 
ATOM   1491 O O   . SER A 1 207 ? 5.98444   38.07379  22.39020  1.000 69.05596  ? 207 SER A O   1 
ATOM   1492 C CB  . SER A 1 207 ? 5.23586   36.46387  24.79193  1.000 67.11254  ? 207 SER A CB  1 
ATOM   1493 O OG  . SER A 1 207 ? 6.62585   36.46996  25.07871  1.000 68.01103  ? 207 SER A OG  1 
ATOM   1494 N N   . LEU A 1 208 ? 6.33653   39.64735  23.97323  1.000 59.29721  ? 208 LEU A N   1 
ATOM   1495 C CA  . LEU A 1 208 ? 7.20321   40.44206  23.11027  1.000 62.23313  ? 208 LEU A CA  1 
ATOM   1496 C C   . LEU A 1 208 ? 8.48931   39.69768  22.76633  1.000 59.11922  ? 208 LEU A C   1 
ATOM   1497 O O   . LEU A 1 208 ? 8.98577   39.80321  21.63921  1.000 64.16952  ? 208 LEU A O   1 
ATOM   1498 C CB  . LEU A 1 208 ? 7.50958   41.78539  23.77444  1.000 62.53380  ? 208 LEU A CB  1 
ATOM   1499 C CG  . LEU A 1 208 ? 7.92971   42.94329  22.86446  1.000 68.53726  ? 208 LEU A CG  1 
ATOM   1500 C CD1 . LEU A 1 208 ? 7.61976   44.27390  23.53402  1.000 68.71366  ? 208 LEU A CD1 1 
ATOM   1501 C CD2 . LEU A 1 208 ? 9.41007   42.86941  22.49613  1.000 66.60682  ? 208 LEU A CD2 1 
ATOM   1502 N N   . GLU A 1 209 ? 9.05015   38.94356  23.71515  1.000 55.38824  ? 209 GLU A N   1 
ATOM   1503 C CA  . GLU A 1 209 ? 10.28927  38.23046  23.41685  1.000 61.84506  ? 209 GLU A CA  1 
ATOM   1504 C C   . GLU A 1 209 ? 10.04503  37.09373  22.42794  1.000 60.76729  ? 209 GLU A C   1 
ATOM   1505 O O   . GLU A 1 209 ? 10.84454  36.88239  21.50782  1.000 59.30320  ? 209 GLU A O   1 
ATOM   1506 C CB  . GLU A 1 209 ? 10.94336  37.72159  24.70727  1.000 60.03300  ? 209 GLU A CB  1 
ATOM   1507 C CG  . GLU A 1 209 ? 10.18741  36.63918  25.46817  1.000 57.67543  ? 209 GLU A CG  1 
ATOM   1508 C CD  . GLU A 1 209 ? 10.91345  36.20669  26.73599  1.000 61.35379  ? 209 GLU A CD  1 
ATOM   1509 O OE1 . GLU A 1 209 ? 10.85411  36.94765  27.74254  1.000 51.85541  ? 209 GLU A OE1 1 
ATOM   1510 O OE2 . GLU A 1 209 ? 11.55397  35.13196  26.72411  1.000 57.55343  ? 209 GLU A OE2 1 
ATOM   1511 N N   . LYS A 1 210 ? 8.93434   36.36754  22.58066  1.000 58.20932  ? 210 LYS A N   1 
ATOM   1512 C CA  . LYS A 1 210 ? 8.59917   35.34092  21.60034  1.000 63.46295  ? 210 LYS A CA  1 
ATOM   1513 C C   . LYS A 1 210 ? 8.19236   35.96284  20.27070  1.000 64.64779  ? 210 LYS A C   1 
ATOM   1514 O O   . LYS A 1 210 ? 8.38544   35.34737  19.21559  1.000 61.00808  ? 210 LYS A O   1 
ATOM   1515 C CB  . LYS A 1 210 ? 7.48408   34.43711  22.13312  1.000 68.34822  ? 210 LYS A CB  1 
ATOM   1516 C CG  . LYS A 1 210 ? 7.49683   33.01891  21.56231  1.000 73.12035  ? 210 LYS A CG  1 
ATOM   1517 C CD  . LYS A 1 210 ? 8.81339   32.32060  21.88282  1.000 70.74962  ? 210 LYS A CD  1 
ATOM   1518 C CE  . LYS A 1 210 ? 8.74794   30.81440  21.64419  1.000 74.01097  ? 210 LYS A CE  1 
ATOM   1519 N NZ  . LYS A 1 210 ? 8.81584   30.42761  20.20587  1.000 79.92693  ? 210 LYS A NZ  1 
ATOM   1520 N N   . LYS A 1 211 ? 7.63461   37.17637  20.30166  1.000 57.30012  ? 211 LYS A N   1 
ATOM   1521 C CA  . LYS A 1 211 ? 7.31691   37.88199  19.06481  1.000 56.19203  ? 211 LYS A CA  1 
ATOM   1522 C C   . LYS A 1 211 ? 8.57707   38.15598  18.25390  1.000 61.41825  ? 211 LYS A C   1 
ATOM   1523 O O   . LYS A 1 211 ? 8.62273   37.89581  17.04564  1.000 56.83677  ? 211 LYS A O   1 
ATOM   1524 C CB  . LYS A 1 211 ? 6.58418   39.18820  19.37928  1.000 61.83929  ? 211 LYS A CB  1 
ATOM   1525 C CG  . LYS A 1 211 ? 6.68542   40.23307  18.27807  1.000 58.21733  ? 211 LYS A CG  1 
ATOM   1526 C CD  . LYS A 1 211 ? 6.04207   41.54845  18.68771  1.000 64.35128  ? 211 LYS A CD  1 
ATOM   1527 C CE  . LYS A 1 211 ? 4.53575   41.51664  18.51352  1.000 64.37239  ? 211 LYS A CE  1 
ATOM   1528 N NZ  . LYS A 1 211 ? 3.89560   42.79146  18.95244  1.000 67.55161  ? 211 LYS A NZ  1 
ATOM   1529 N N   . GLN A 1 212 ? 9.61975   38.67187  18.90881  1.000 54.82679  ? 212 GLN A N   1 
ATOM   1530 C CA  . GLN A 1 212 ? 10.83734  39.02790  18.18993  1.000 59.53646  ? 212 GLN A CA  1 
ATOM   1531 C C   . GLN A 1 212 ? 11.58010  37.79549  17.68965  1.000 57.94800  ? 212 GLN A C   1 
ATOM   1532 O O   . GLN A 1 212 ? 12.21558  37.84691  16.62985  1.000 58.41912  ? 212 GLN A O   1 
ATOM   1533 C CB  . GLN A 1 212 ? 11.74900  39.86823  19.08384  1.000 65.87050  ? 212 GLN A CB  1 
ATOM   1534 C CG  . GLN A 1 212 ? 12.85327  40.59021  18.32979  1.000 70.17232  ? 212 GLN A CG  1 
ATOM   1535 C CD  . GLN A 1 212 ? 12.31319  41.66524  17.40673  1.000 76.55545  ? 212 GLN A CD  1 
ATOM   1536 O OE1 . GLN A 1 212 ? 11.31172  42.31564  17.71175  1.000 79.50946  ? 212 GLN A OE1 1 
ATOM   1537 N NE2 . GLN A 1 212 ? 12.97068  41.85365  16.26773  1.000 78.53572  ? 212 GLN A NE2 1 
ATOM   1538 N N   . GLU A 1 213 ? 11.51956  36.68768  18.43243  1.000 54.01933  ? 213 GLU A N   1 
ATOM   1539 C CA  . GLU A 1 213 ? 12.20244  35.47273  17.99763  1.000 63.00426  ? 213 GLU A CA  1 
ATOM   1540 C C   . GLU A 1 213 ? 11.61476  34.95199  16.69105  1.000 59.78673  ? 213 GLU A C   1 
ATOM   1541 O O   . GLU A 1 213 ? 12.34382  34.70034  15.72491  1.000 56.07759  ? 213 GLU A O   1 
ATOM   1542 C CB  . GLU A 1 213 ? 12.12224  34.40018  19.08451  1.000 59.53551  ? 213 GLU A CB  1 
ATOM   1543 C CG  . GLU A 1 213 ? 12.80355  33.09121  18.69607  1.000 62.78836  ? 213 GLU A CG  1 
ATOM   1544 C CD  . GLU A 1 213 ? 12.51404  31.96084  19.66663  1.000 70.62906  ? 213 GLU A CD  1 
ATOM   1545 O OE1 . GLU A 1 213 ? 11.68675  32.15431  20.58192  1.000 70.06225  ? 213 GLU A OE1 1 
ATOM   1546 O OE2 . GLU A 1 213 ? 13.11520  30.87660  19.51257  1.000 78.56419  ? 213 GLU A OE2 1 
ATOM   1547 N N   . LEU A 1 214 ? 10.29016  34.78684  16.64417  1.000 56.20769  ? 214 LEU A N   1 
ATOM   1548 C CA  . LEU A 1 214 ? 9.65178   34.25407  15.44540  1.000 51.03287  ? 214 LEU A CA  1 
ATOM   1549 C C   . LEU A 1 214 ? 9.89025   35.15317  14.23904  1.000 57.40908  ? 214 LEU A C   1 
ATOM   1550 O O   . LEU A 1 214 ? 10.16170  34.66259  13.13621  1.000 58.27411  ? 214 LEU A O   1 
ATOM   1551 C CB  . LEU A 1 214 ? 8.15613   34.07239  15.69113  1.000 57.59158  ? 214 LEU A CB  1 
ATOM   1552 C CG  . LEU A 1 214 ? 7.79639   33.05553  16.77405  1.000 58.03331  ? 214 LEU A CG  1 
ATOM   1553 C CD1 . LEU A 1 214 ? 6.30355   33.05092  17.00087  1.000 56.85007  ? 214 LEU A CD1 1 
ATOM   1554 C CD2 . LEU A 1 214 ? 8.28279   31.67021  16.39132  1.000 46.11762  ? 214 LEU A CD2 1 
ATOM   1555 N N   . LEU A 1 215 ? 9.80700   36.47331  14.42890  1.000 53.76909  ? 215 LEU A N   1 
ATOM   1556 C CA  . LEU A 1 215 ? 9.96537   37.38868  13.30275  1.000 47.82607  ? 215 LEU A CA  1 
ATOM   1557 C C   . LEU A 1 215 ? 11.36816  37.30573  12.71371  1.000 54.91213  ? 215 LEU A C   1 
ATOM   1558 O O   . LEU A 1 215 ? 11.54268  37.38807  11.49207  1.000 52.76302  ? 215 LEU A O   1 
ATOM   1559 C CB  . LEU A 1 215 ? 9.64093   38.81973  13.73615  1.000 54.11753  ? 215 LEU A CB  1 
ATOM   1560 C CG  . LEU A 1 215 ? 8.16176   39.07923  14.03952  1.000 51.02726  ? 215 LEU A CG  1 
ATOM   1561 C CD1 . LEU A 1 215 ? 7.94090   40.45102  14.64908  1.000 57.74341  ? 215 LEU A CD1 1 
ATOM   1562 C CD2 . LEU A 1 215 ? 7.30974   38.90931  12.78596  1.000 54.14082  ? 215 LEU A CD2 1 
ATOM   1563 N N   . ASP A 1 216 ? 12.38144  37.12668  13.56207  1.000 54.23043  ? 216 ASP A N   1 
ATOM   1564 C CA  . ASP A 1 216 ? 13.74742  37.03415  13.05793  1.000 51.58363  ? 216 ASP A CA  1 
ATOM   1565 C C   . ASP A 1 216 ? 13.98190  35.73740  12.29364  1.000 52.91279  ? 216 ASP A C   1 
ATOM   1566 O O   . ASP A 1 216 ? 14.77918  35.71194  11.34880  1.000 52.09699  ? 216 ASP A O   1 
ATOM   1567 C CB  . ASP A 1 216 ? 14.74271  37.15544  14.21094  1.000 64.93104  ? 216 ASP A CB  1 
ATOM   1568 C CG  . ASP A 1 216 ? 14.75725  38.54235  14.82593  1.000 66.23342  ? 216 ASP A CG  1 
ATOM   1569 O OD1 . ASP A 1 216 ? 14.17422  39.47219  14.22714  1.000 70.65105  ? 216 ASP A OD1 1 
ATOM   1570 O OD2 . ASP A 1 216 ? 15.35488  38.70235  15.91118  1.000 73.66165  ? 216 ASP A OD2 1 
ATOM   1571 N N   . LEU A 1 217 ? 13.30748  34.65588  12.68533  1.000 51.10415  ? 217 LEU A N   1 
ATOM   1572 C CA  . LEU A 1 217 ? 13.45497  33.38571  11.98079  1.000 55.50093  ? 217 LEU A CA  1 
ATOM   1573 C C   . LEU A 1 217 ? 12.62219  33.35797  10.70386  1.000 53.64746  ? 217 LEU A C   1 
ATOM   1574 O O   . LEU A 1 217 ? 13.10601  32.94759  9.64149   1.000 56.23333  ? 217 LEU A O   1 
ATOM   1575 C CB  . LEU A 1 217 ? 13.05782  32.22465  12.89749  1.000 48.88816  ? 217 LEU A CB  1 
ATOM   1576 C CG  . LEU A 1 217 ? 12.76971  30.88772  12.19995  1.000 64.74474  ? 217 LEU A CG  1 
ATOM   1577 C CD1 . LEU A 1 217 ? 14.01814  30.33132  11.51764  1.000 53.31225  ? 217 LEU A CD1 1 
ATOM   1578 C CD2 . LEU A 1 217 ? 12.18386  29.86926  13.16807  1.000 56.83747  ? 217 LEU A CD2 1 
ATOM   1579 N N   . ILE A 1 218 ? 11.36894  33.79638  10.79147  1.000 49.07793  ? 218 ILE A N   1 
ATOM   1580 C CA  . ILE A 1 218 ? 10.45271  33.65990  9.66562   1.000 51.92383  ? 218 ILE A CA  1 
ATOM   1581 C C   . ILE A 1 218 ? 10.67316  34.76014  8.63032   1.000 46.43737  ? 218 ILE A C   1 
ATOM   1582 O O   . ILE A 1 218 ? 10.54738  34.51852  7.42162   1.000 45.67169  ? 218 ILE A O   1 
ATOM   1583 C CB  . ILE A 1 218 ? 9.00747   33.63853  10.18979  1.000 44.70871  ? 218 ILE A CB  1 
ATOM   1584 C CG1 . ILE A 1 218 ? 8.82806   32.46260  11.15566  1.000 43.88399  ? 218 ILE A CG1 1 
ATOM   1585 C CG2 . ILE A 1 218 ? 8.02081   33.54708  9.04126   1.000 44.22179  ? 218 ILE A CG2 1 
ATOM   1586 C CD1 . ILE A 1 218 ? 7.52518   32.46878  11.89652  1.000 40.41524  ? 218 ILE A CD1 1 
ATOM   1587 N N   . PHE A 1 219 ? 11.01867  35.96927  9.06612   1.000 44.08617  ? 219 PHE A N   1 
ATOM   1588 C CA  . PHE A 1 219 ? 11.24872  37.09625  8.16599   1.000 43.92550  ? 219 PHE A CA  1 
ATOM   1589 C C   . PHE A 1 219 ? 12.65593  37.63855  8.38912   1.000 49.81242  ? 219 PHE A C   1 
ATOM   1590 O O   . PHE A 1 219 ? 12.83067  38.75128  8.90626   1.000 51.18594  ? 219 PHE A O   1 
ATOM   1591 C CB  . PHE A 1 219 ? 10.19905  38.18543  8.37997   1.000 40.37547  ? 219 PHE A CB  1 
ATOM   1592 C CG  . PHE A 1 219 ? 8.78609   37.71937  8.15936   1.000 39.56170  ? 219 PHE A CG  1 
ATOM   1593 C CD1 . PHE A 1 219 ? 8.30539   37.50960  6.87909   1.000 41.97399  ? 219 PHE A CD1 1 
ATOM   1594 C CD2 . PHE A 1 219 ? 7.93503   37.50455  9.23168   1.000 37.61818  ? 219 PHE A CD2 1 
ATOM   1595 C CE1 . PHE A 1 219 ? 7.00122   37.09477  6.66898   1.000 34.54430  ? 219 PHE A CE1 1 
ATOM   1596 C CE2 . PHE A 1 219 ? 6.62929   37.08635  9.03147   1.000 39.81838  ? 219 PHE A CE2 1 
ATOM   1597 C CZ  . PHE A 1 219 ? 6.16084   36.87582  7.74955   1.000 40.72202  ? 219 PHE A CZ  1 
ATOM   1598 N N   . PRO A 1 220 ? 13.68057  36.88581  7.99447   1.000 48.63944  ? 220 PRO A N   1 
ATOM   1599 C CA  . PRO A 1 220 ? 15.05786  37.31687  8.25638   1.000 54.10737  ? 220 PRO A CA  1 
ATOM   1600 C C   . PRO A 1 220 ? 15.46282  38.48350  7.36921   1.000 54.30188  ? 220 PRO A C   1 
ATOM   1601 O O   . PRO A 1 220 ? 14.90283  38.71956  6.29681   1.000 51.10808  ? 220 PRO A O   1 
ATOM   1602 C CB  . PRO A 1 220 ? 15.88250  36.06792  7.93742   1.000 56.90424  ? 220 PRO A CB  1 
ATOM   1603 C CG  . PRO A 1 220 ? 15.08240  35.37762  6.88521   1.000 45.69020  ? 220 PRO A CG  1 
ATOM   1604 C CD  . PRO A 1 220 ? 13.64047  35.61382  7.25056   1.000 46.40813  ? 220 PRO A CD  1 
ATOM   1605 N N   . SER A 1 221 ? 16.47317  39.21665  7.83600   1.000 56.74790  ? 221 SER A N   1 
ATOM   1606 C CA  . SER A 1 221 ? 16.95263  40.38102  7.10383   1.000 54.49459  ? 221 SER A CA  1 
ATOM   1607 C C   . SER A 1 221 ? 17.79515  40.01545  5.88648   1.000 47.19680  ? 221 SER A C   1 
ATOM   1608 O O   . SER A 1 221 ? 17.90563  40.82788  4.96297   1.000 51.06843  ? 221 SER A O   1 
ATOM   1609 C CB  . SER A 1 221 ? 17.75261  41.29383  8.03763   1.000 61.76297  ? 221 SER A CB  1 
ATOM   1610 O OG  . SER A 1 221 ? 18.72222  40.55913  8.76233   1.000 65.68580  ? 221 SER A OG  1 
ATOM   1611 N N   . ASN A 1 222 ? 18.38070  38.81915  5.84988   1.000 45.80194  ? 222 ASN A N   1 
ATOM   1612 C CA  . ASN A 1 222 ? 19.15675  38.37394  4.69802   1.000 56.22910  ? 222 ASN A CA  1 
ATOM   1613 C C   . ASN A 1 222 ? 18.35324  37.46588  3.77013   1.000 51.09781  ? 222 ASN A C   1 
ATOM   1614 O O   . ASN A 1 222 ? 18.93375  36.64027  3.05821   1.000 51.18362  ? 222 ASN A O   1 
ATOM   1615 C CB  . ASN A 1 222 ? 20.43507  37.66925  5.15585   1.000 60.42894  ? 222 ASN A CB  1 
ATOM   1616 C CG  . ASN A 1 222 ? 20.15857  36.37220  5.89257   1.000 61.46504  ? 222 ASN A CG  1 
ATOM   1617 O OD1 . ASN A 1 222 ? 19.12501  36.22219  6.54675   1.000 64.49918  ? 222 ASN A OD1 1 
ATOM   1618 N ND2 . ASN A 1 222 ? 21.08610  35.42468  5.78965   1.000 62.93320  ? 222 ASN A ND2 1 
ATOM   1619 N N   . LEU A 1 223 ? 17.02405  37.61833  3.75222   1.000 53.53875  ? 223 LEU A N   1 
ATOM   1620 C CA  . LEU A 1 223 ? 16.17780  36.73227  2.95579   1.000 44.10129  ? 223 LEU A CA  1 
ATOM   1621 C C   . LEU A 1 223 ? 16.55589  36.77155  1.48026   1.000 42.18963  ? 223 LEU A C   1 
ATOM   1622 O O   . LEU A 1 223 ? 16.56540  35.73366  0.80831   1.000 42.64309  ? 223 LEU A O   1 
ATOM   1623 C CB  . LEU A 1 223 ? 14.70799  37.10928  3.14141   1.000 42.88601  ? 223 LEU A CB  1 
ATOM   1624 C CG  . LEU A 1 223 ? 13.70094  36.31586  2.30821   1.000 39.34827  ? 223 LEU A CG  1 
ATOM   1625 C CD1 . LEU A 1 223 ? 13.73920  34.82799  2.67739   1.000 39.33091  ? 223 LEU A CD1 1 
ATOM   1626 C CD2 . LEU A 1 223 ? 12.29598  36.88043  2.48379   1.000 36.60074  ? 223 LEU A CD2 1 
ATOM   1627 N N   . ALA A 1 224 ? 16.87595  37.95950  0.95794   1.000 46.59446  ? 224 ALA A N   1 
ATOM   1628 C CA  . ALA A 1 224 ? 17.28853  38.06678  -0.43851  1.000 42.94929  ? 224 ALA A CA  1 
ATOM   1629 C C   . ALA A 1 224 ? 18.53082  37.22472  -0.70560  1.000 51.79465  ? 224 ALA A C   1 
ATOM   1630 O O   . ALA A 1 224 ? 18.58692  36.47517  -1.68839  1.000 45.95494  ? 224 ALA A O   1 
ATOM   1631 C CB  . ALA A 1 224 ? 17.53523  39.52917  -0.80653  1.000 42.22745  ? 224 ALA A CB  1 
ATOM   1632 N N   . ASP A 1 225 ? 19.53554  37.33155  0.17069   1.000 50.81680  ? 225 ASP A N   1 
ATOM   1633 C CA  . ASP A 1 225 ? 20.72586  36.49344  0.05273   1.000 48.08351  ? 225 ASP A CA  1 
ATOM   1634 C C   . ASP A 1 225 ? 20.36520  35.01543  0.08538   1.000 50.37271  ? 225 ASP A C   1 
ATOM   1635 O O   . ASP A 1 225 ? 20.89508  34.22064  -0.70060  1.000 50.13972  ? 225 ASP A O   1 
ATOM   1636 C CB  . ASP A 1 225 ? 21.71269  36.81613  1.17581   1.000 57.76804  ? 225 ASP A CB  1 
ATOM   1637 C CG  . ASP A 1 225 ? 22.40475  38.15620  0.98799   1.000 64.69623  ? 225 ASP A CG  1 
ATOM   1638 O OD1 . ASP A 1 225 ? 22.07306  38.87805  0.02391   1.000 66.54289  ? 225 ASP A OD1 1 
ATOM   1639 O OD2 . ASP A 1 225 ? 23.29097  38.48456  1.80672   1.000 72.83823  ? 225 ASP A OD2 1 
ATOM   1640 N N   . ILE A 1 226 ? 19.46314  34.63032  0.99066   1.000 54.10691  ? 226 ILE A N   1 
ATOM   1641 C CA  . ILE A 1 226 ? 19.06800  33.22942  1.11338   1.000 48.23651  ? 226 ILE A CA  1 
ATOM   1642 C C   . ILE A 1 226 ? 18.43708  32.74016  -0.18388  1.000 52.15146  ? 226 ILE A C   1 
ATOM   1643 O O   . ILE A 1 226 ? 18.79589  31.67892  -0.70701  1.000 52.17947  ? 226 ILE A O   1 
ATOM   1644 C CB  . ILE A 1 226 ? 18.11685  33.04858  2.30955   1.000 47.31143  ? 226 ILE A CB  1 
ATOM   1645 C CG1 . ILE A 1 226 ? 18.82472  33.43874  3.60763   1.000 54.45230  ? 226 ILE A CG1 1 
ATOM   1646 C CG2 . ILE A 1 226 ? 17.60801  31.61988  2.37964   1.000 49.76816  ? 226 ILE A CG2 1 
ATOM   1647 C CD1 . ILE A 1 226 ? 17.90373  33.53815  4.80171   1.000 54.31469  ? 226 ILE A CD1 1 
ATOM   1648 N N   . LEU A 1 227 ? 17.49388  33.51424  -0.72774  1.000 49.93298  ? 227 LEU A N   1 
ATOM   1649 C CA  . LEU A 1 227 ? 16.82033  33.11432  -1.95880  1.000 44.34602  ? 227 LEU A CA  1 
ATOM   1650 C C   . LEU A 1 227 ? 17.81610  32.92945  -3.09945  1.000 45.59548  ? 227 LEU A C   1 
ATOM   1651 O O   . LEU A 1 227 ? 17.75930  31.93671  -3.83410  1.000 46.88244  ? 227 LEU A O   1 
ATOM   1652 C CB  . LEU A 1 227 ? 15.75272  34.14679  -2.32994  1.000 40.30920  ? 227 LEU A CB  1 
ATOM   1653 C CG  . LEU A 1 227 ? 14.55339  34.22974  -1.38168  1.000 48.40344  ? 227 LEU A CG  1 
ATOM   1654 C CD1 . LEU A 1 227 ? 13.53684  35.25929  -1.86102  1.000 38.26654  ? 227 LEU A CD1 1 
ATOM   1655 C CD2 . LEU A 1 227 ? 13.90043  32.85864  -1.22484  1.000 43.97443  ? 227 LEU A CD2 1 
ATOM   1656 N N   . VAL A 1 228 ? 18.74405  33.87440  -3.25901  1.000 48.39004  ? 228 VAL A N   1 
ATOM   1657 C CA  . VAL A 1 228 ? 19.71128  33.78972  -4.35213  1.000 45.64779  ? 228 VAL A CA  1 
ATOM   1658 C C   . VAL A 1 228 ? 20.67416  32.63065  -4.12780  1.000 44.92387  ? 228 VAL A C   1 
ATOM   1659 O O   . VAL A 1 228 ? 20.92888  31.83003  -5.03429  1.000 49.51714  ? 228 VAL A O   1 
ATOM   1660 C CB  . VAL A 1 228 ? 20.46924  35.12186  -4.50723  1.000 47.29544  ? 228 VAL A CB  1 
ATOM   1661 C CG1 . VAL A 1 228 ? 21.75126  34.91257  -5.29636  1.000 47.24629  ? 228 VAL A CG1 1 
ATOM   1662 C CG2 . VAL A 1 228 ? 19.59703  36.15546  -5.19045  1.000 46.82012  ? 228 VAL A CG2 1 
ATOM   1663 N N   . GLN A 1 229 ? 21.23531  32.53565  -2.92002  1.000 50.72951  ? 229 GLN A N   1 
ATOM   1664 C CA  . GLN A 1 229 ? 22.23929  31.51565  -2.63506  1.000 48.20077  ? 229 GLN A CA  1 
ATOM   1665 C C   . GLN A 1 229 ? 21.66991  30.11158  -2.80500  1.000 56.78474  ? 229 GLN A C   1 
ATOM   1666 O O   . GLN A 1 229 ? 22.38596  29.19482  -3.22794  1.000 49.91543  ? 229 GLN A O   1 
ATOM   1667 C CB  . GLN A 1 229 ? 22.78450  31.72099  -1.21832  1.000 49.76089  ? 229 GLN A CB  1 
ATOM   1668 C CG  . GLN A 1 229 ? 24.08278  30.99630  -0.90344  1.000 71.32052  ? 229 GLN A CG  1 
ATOM   1669 C CD  . GLN A 1 229 ? 23.87105  29.70548  -0.13083  1.000 67.98941  ? 229 GLN A CD  1 
ATOM   1670 O OE1 . GLN A 1 229 ? 22.90374  28.98122  -0.35885  1.000 66.65983  ? 229 GLN A OE1 1 
ATOM   1671 N NE2 . GLN A 1 229 ? 24.77896  29.41586  0.79477   1.000 77.14938  ? 229 GLN A NE2 1 
ATOM   1672 N N   . ARG A 1 230 ? 20.38388  29.92913  -2.49685  1.000 52.66424  ? 230 ARG A N   1 
ATOM   1673 C CA  . ARG A 1 230 ? 19.74643  28.63567  -2.70467  1.000 51.65415  ? 230 ARG A CA  1 
ATOM   1674 C C   . ARG A 1 230 ? 19.76127  28.22720  -4.17287  1.000 50.11021  ? 230 ARG A C   1 
ATOM   1675 O O   . ARG A 1 230 ? 19.88005  27.03594  -4.48329  1.000 60.47469  ? 230 ARG A O   1 
ATOM   1676 C CB  . ARG A 1 230 ? 18.31472  28.67217  -2.17132  1.000 59.19764  ? 230 ARG A CB  1 
ATOM   1677 C CG  . ARG A 1 230 ? 17.50119  27.44260  -2.53203  1.000 56.10209  ? 230 ARG A CG  1 
ATOM   1678 C CD  . ARG A 1 230 ? 16.05756  27.55338  -2.07943  1.000 62.10918  ? 230 ARG A CD  1 
ATOM   1679 N NE  . ARG A 1 230 ? 15.19001  26.72411  -2.91110  1.000 60.66435  ? 230 ARG A NE  1 
ATOM   1680 C CZ  . ARG A 1 230 ? 15.03632  25.41284  -2.75499  1.000 65.01920  ? 230 ARG A CZ  1 
ATOM   1681 N NH1 . ARG A 1 230 ? 15.68750  24.77879  -1.78732  1.000 67.85230  ? 230 ARG A NH1 1 
ATOM   1682 N NH2 . ARG A 1 230 ? 14.23095  24.73437  -3.56524  1.000 54.58121  ? 230 ARG A NH2 1 
ATOM   1683 N N   . ARG A 1 231 ? 19.65482  29.18982  -5.08800  1.000 50.82539  ? 231 ARG A N   1 
ATOM   1684 C CA  . ARG A 1 231 ? 19.66062  28.88895  -6.51603  1.000 54.87443  ? 231 ARG A CA  1 
ATOM   1685 C C   . ARG A 1 231 ? 21.05791  28.83504  -7.11851  1.000 59.37077  ? 231 ARG A C   1 
ATOM   1686 O O   . ARG A 1 231 ? 21.28417  28.06770  -8.06178  1.000 55.32731  ? 231 ARG A O   1 
ATOM   1687 C CB  . ARG A 1 231 ? 18.84746  29.93044  -7.29160  1.000 49.76229  ? 231 ARG A CB  1 
ATOM   1688 C CG  . ARG A 1 231 ? 17.34475  29.76949  -7.22470  1.000 53.59553  ? 231 ARG A CG  1 
ATOM   1689 C CD  . ARG A 1 231 ? 16.64605  30.61630  -8.29425  1.000 53.78306  ? 231 ARG A CD  1 
ATOM   1690 N NE  . ARG A 1 231 ? 16.76555  32.05474  -8.05275  1.000 50.60222  ? 231 ARG A NE  1 
ATOM   1691 C CZ  . ARG A 1 231 ? 17.65034  32.84743  -8.65201  1.000 50.99537  ? 231 ARG A CZ  1 
ATOM   1692 N NH1 . ARG A 1 231 ? 18.50307  32.34781  -9.53532  1.000 57.27068  ? 231 ARG A NH1 1 
ATOM   1693 N NH2 . ARG A 1 231 ? 17.68497  34.14324  -8.36972  1.000 45.49446  ? 231 ARG A NH2 1 
ATOM   1694 N N   . THR A 1 232 ? 21.99848  29.63449  -6.60848  1.000 55.97828  ? 232 THR A N   1 
ATOM   1695 C CA  . THR A 1 232 ? 23.27310  29.85716  -7.27855  1.000 48.70202  ? 232 THR A CA  1 
ATOM   1696 C C   . THR A 1 232 ? 24.49115  29.43544  -6.47232  1.000 48.07734  ? 232 THR A C   1 
ATOM   1697 O O   . THR A 1 232 ? 25.58879  29.37417  -7.03803  1.000 53.11508  ? 232 THR A O   1 
ATOM   1698 C CB  . THR A 1 232 ? 23.43536  31.34341  -7.64072  1.000 54.04898  ? 232 THR A CB  1 
ATOM   1699 O OG1 . THR A 1 232 ? 23.50247  32.11714  -6.43856  1.000 49.56103  ? 232 THR A OG1 1 
ATOM   1700 C CG2 . THR A 1 232 ? 22.26296  31.83247  -8.48278  1.000 55.63454  ? 232 THR A CG2 1 
ATOM   1701 N N   . GLY A 1 233 ? 24.34679  29.16349  -5.18625  1.000 47.67513  ? 233 GLY A N   1 
ATOM   1702 C CA  . GLY A 1 233 ? 25.49643  28.86524  -4.36083  1.000 52.69650  ? 233 GLY A CA  1 
ATOM   1703 C C   . GLY A 1 233 ? 26.04227  30.09534  -3.66574  1.000 58.91456  ? 233 GLY A C   1 
ATOM   1704 O O   . GLY A 1 233 ? 25.47535  31.19129  -3.71186  1.000 56.11424  ? 233 GLY A O   1 
ATOM   1705 N N   . ASP A 1 234 ? 27.19571  29.90215  -3.02207  1.000 65.36144  ? 234 ASP A N   1 
ATOM   1706 C CA  . ASP A 1 234 ? 27.80416  30.94470  -2.20258  1.000 65.72644  ? 234 ASP A CA  1 
ATOM   1707 C C   . ASP A 1 234 ? 28.29459  32.14693  -3.00102  1.000 54.59645  ? 234 ASP A C   1 
ATOM   1708 O O   . ASP A 1 234 ? 28.58519  33.18256  -2.39543  1.000 55.51329  ? 234 ASP A O   1 
ATOM   1709 C CB  . ASP A 1 234 ? 28.97058  30.36417  -1.39883  1.000 69.75519  ? 234 ASP A CB  1 
ATOM   1710 C CG  . ASP A 1 234 ? 28.51163  29.62861  -0.16005  1.000 84.38419  ? 234 ASP A CG  1 
ATOM   1711 O OD1 . ASP A 1 234 ? 27.44959  29.99770  0.38468   1.000 85.28527  ? 234 ASP A OD1 1 
ATOM   1712 O OD2 . ASP A 1 234 ? 29.20926  28.68448  0.26755   1.000 87.64407  ? 234 ASP A OD2 1 
ATOM   1713 N N   . SER A 1 235 ? 28.40108  32.04656  -4.32547  1.000 51.38596  ? 235 SER A N   1 
ATOM   1714 C CA  . SER A 1 235 ? 28.97332  33.13421  -5.10924  1.000 53.70443  ? 235 SER A CA  1 
ATOM   1715 C C   . SER A 1 235 ? 27.93717  34.13262  -5.61065  1.000 54.51072  ? 235 SER A C   1 
ATOM   1716 O O   . SER A 1 235 ? 28.32032  35.19541  -6.10958  1.000 50.76502  ? 235 SER A O   1 
ATOM   1717 C CB  . SER A 1 235 ? 29.75189  32.57932  -6.30613  1.000 48.80865  ? 235 SER A CB  1 
ATOM   1718 O OG  . SER A 1 235 ? 28.87539  32.23301  -7.36201  1.000 55.29719  ? 235 SER A OG  1 
ATOM   1719 N N   . GLY A 1 236 ? 26.64745  33.82655  -5.49944  1.000 48.79633  ? 236 GLY A N   1 
ATOM   1720 C CA  . GLY A 1 236 ? 25.63250  34.74206  -5.98332  1.000 52.20269  ? 236 GLY A CA  1 
ATOM   1721 C C   . GLY A 1 236 ? 25.31015  35.83337  -4.97662  1.000 48.84201  ? 236 GLY A C   1 
ATOM   1722 O O   . GLY A 1 236 ? 25.35766  35.63507  -3.76448  1.000 50.06597  ? 236 GLY A O   1 
ATOM   1723 N N   . ASP A 1 237 ? 24.99030  37.02009  -5.49503  1.000 52.81229  ? 237 ASP A N   1 
ATOM   1724 C CA  . ASP A 1 237 ? 24.50629  38.08107  -4.61956  1.000 46.99865  ? 237 ASP A CA  1 
ATOM   1725 C C   . ASP A 1 237 ? 23.23604  38.68547  -5.20316  1.000 45.84325  ? 237 ASP A C   1 
ATOM   1726 O O   . ASP A 1 237 ? 22.71539  38.18929  -6.20915  1.000 41.97973  ? 237 ASP A O   1 
ATOM   1727 C CB  . ASP A 1 237 ? 25.60011  39.13919  -4.35779  1.000 46.10509  ? 237 ASP A CB  1 
ATOM   1728 C CG  . ASP A 1 237 ? 25.81816  40.11592  -5.52081  1.000 46.90659  ? 237 ASP A CG  1 
ATOM   1729 O OD1 . ASP A 1 237 ? 25.30451  39.90193  -6.64017  1.000 42.54007  ? 237 ASP A OD1 1 
ATOM   1730 O OD2 . ASP A 1 237 ? 26.53163  41.12297  -5.29636  1.000 43.47243  ? 237 ASP A OD2 1 
ATOM   1731 N N   . ILE A 1 238 ? 22.73457  39.75833  -4.58774  1.000 40.58732  ? 238 ILE A N   1 
ATOM   1732 C CA  . ILE A 1 238 ? 21.41372  40.27455  -4.92165  1.000 39.21868  ? 238 ILE A CA  1 
ATOM   1733 C C   . ILE A 1 238 ? 21.31554  40.77686  -6.35838  1.000 36.10806  ? 238 ILE A C   1 
ATOM   1734 O O   . ILE A 1 238 ? 20.21444  41.06694  -6.82563  1.000 42.82193  ? 238 ILE A O   1 
ATOM   1735 C CB  . ILE A 1 238 ? 21.03742  41.35196  -3.88566  1.000 44.36723  ? 238 ILE A CB  1 
ATOM   1736 C CG1 . ILE A 1 238 ? 19.51992  41.47569  -3.76149  1.000 49.30282  ? 238 ILE A CG1 1 
ATOM   1737 C CG2 . ILE A 1 238 ? 21.69012  42.68352  -4.23149  1.000 42.95216  ? 238 ILE A CG2 1 
ATOM   1738 C CD1 . ILE A 1 238 ? 19.07539  42.26883  -2.55822  1.000 58.10580  ? 238 ILE A CD1 1 
ATOM   1739 N N   . THR A 1 239 ? 22.43738  40.84989  -7.08190  1.000 40.25557  ? 239 THR A N   1 
ATOM   1740 C CA  . THR A 1 239 ? 22.38879  41.15499  -8.50860  1.000 39.79369  ? 239 THR A CA  1 
ATOM   1741 C C   . THR A 1 239 ? 21.50970  40.16038  -9.26463  1.000 46.87729  ? 239 THR A C   1 
ATOM   1742 O O   . THR A 1 239 ? 20.77647  40.54227  -10.18386 1.000 42.26047  ? 239 THR A O   1 
ATOM   1743 C CB  . THR A 1 239 ? 23.80610  41.15118  -9.08822  1.000 43.09417  ? 239 THR A CB  1 
ATOM   1744 O OG1 . THR A 1 239 ? 24.64426  42.03357  -8.32947  1.000 44.67061  ? 239 THR A OG1 1 
ATOM   1745 C CG2 . THR A 1 239 ? 23.80551  41.59174  -10.54533 1.000 44.11932  ? 239 THR A CG2 1 
ATOM   1746 N N   . LEU A 1 240 ? 21.57602  38.88062  -8.89660  1.000 45.28769  ? 240 LEU A N   1 
ATOM   1747 C CA  . LEU A 1 240 ? 20.83301  37.82191  -9.56729  1.000 43.50347  ? 240 LEU A CA  1 
ATOM   1748 C C   . LEU A 1 240 ? 19.41971  37.64512  -9.02849  1.000 50.91412  ? 240 LEU A C   1 
ATOM   1749 O O   . LEU A 1 240 ? 18.67827  36.80354  -9.54859  1.000 46.87172  ? 240 LEU A O   1 
ATOM   1750 C CB  . LEU A 1 240 ? 21.58301  36.49659  -9.44477  1.000 41.71940  ? 240 LEU A CB  1 
ATOM   1751 C CG  . LEU A 1 240 ? 23.08070  36.54161  -9.73415  1.000 46.95381  ? 240 LEU A CG  1 
ATOM   1752 C CD1 . LEU A 1 240 ? 23.69541  35.15286  -9.60918  1.000 47.92287  ? 240 LEU A CD1 1 
ATOM   1753 C CD2 . LEU A 1 240 ? 23.34495  37.13757  -11.10994 1.000 50.22132  ? 240 LEU A CD2 1 
ATOM   1754 N N   . LEU A 1 241 ? 19.03548  38.40243  -8.00283  1.000 44.39591  ? 241 LEU A N   1 
ATOM   1755 C CA  . LEU A 1 241 ? 17.67402  38.33513  -7.48642  1.000 44.20488  ? 241 LEU A CA  1 
ATOM   1756 C C   . LEU A 1 241 ? 16.68163  38.62178  -8.60759  1.000 42.08063  ? 241 LEU A C   1 
ATOM   1757 O O   . LEU A 1 241 ? 16.80453  39.62389  -9.31780  1.000 44.21600  ? 241 LEU A O   1 
ATOM   1758 C CB  . LEU A 1 241 ? 17.50844  39.33612  -6.34078  1.000 41.87822  ? 241 LEU A CB  1 
ATOM   1759 C CG  . LEU A 1 241 ? 16.31055  39.23083  -5.39326  1.000 43.39031  ? 241 LEU A CG  1 
ATOM   1760 C CD1 . LEU A 1 241 ? 16.44008  38.03147  -4.46735  1.000 43.86527  ? 241 LEU A CD1 1 
ATOM   1761 C CD2 . LEU A 1 241 ? 16.16710  40.52006  -4.58272  1.000 46.58274  ? 241 LEU A CD2 1 
ATOM   1762 N N   . THR A 1 242 ? 15.71980  37.72249  -8.79569  1.000 37.24672  ? 242 THR A N   1 
ATOM   1763 C CA  . THR A 1 242 ? 14.76192  37.90187  -9.87213  1.000 37.58568  ? 242 THR A CA  1 
ATOM   1764 C C   . THR A 1 242 ? 13.70550  38.92413  -9.46863  1.000 39.43170  ? 242 THR A C   1 
ATOM   1765 O O   . THR A 1 242 ? 13.51751  39.19847  -8.28102  1.000 40.24447  ? 242 THR A O   1 
ATOM   1766 C CB  . THR A 1 242 ? 14.09266  36.57535  -10.23224 1.000 42.51113  ? 242 THR A CB  1 
ATOM   1767 O OG1 . THR A 1 242 ? 13.04960  36.28539  -9.29205  1.000 41.71215  ? 242 THR A OG1 1 
ATOM   1768 C CG2 . THR A 1 242 ? 15.10798  35.43949  -10.23512 1.000 45.84327  ? 242 THR A CG2 1 
ATOM   1769 N N   . PRO A 1 243 ? 13.00964  39.51706  -10.44682 1.000 42.05864  ? 243 PRO A N   1 
ATOM   1770 C CA  . PRO A 1 243 ? 11.93246  40.46106  -10.10227 1.000 43.03684  ? 243 PRO A CA  1 
ATOM   1771 C C   . PRO A 1 243 ? 10.87792  39.87844  -9.17451  1.000 44.42913  ? 243 PRO A C   1 
ATOM   1772 O O   . PRO A 1 243 ? 10.40949  40.57399  -8.26200  1.000 37.94514  ? 243 PRO A O   1 
ATOM   1773 C CB  . PRO A 1 243 ? 11.34924  40.82500  -11.47511 1.000 43.78502  ? 243 PRO A CB  1 
ATOM   1774 C CG  . PRO A 1 243 ? 12.49732  40.68464  -12.40812 1.000 46.96347  ? 243 PRO A CG  1 
ATOM   1775 C CD  . PRO A 1 243 ? 13.32185  39.53756  -11.88854 1.000 47.03448  ? 243 PRO A CD  1 
ATOM   1776 N N   . SER A 1 244 ? 10.47647  38.62062  -9.38913  1.000 40.43520  ? 244 SER A N   1 
ATOM   1777 C CA  . SER A 1 244 ? 9.50525   37.99712  -8.49448  1.000 36.61287  ? 244 SER A CA  1 
ATOM   1778 C C   . SER A 1 244 ? 10.06766  37.86169  -7.08707  1.000 33.21253  ? 244 SER A C   1 
ATOM   1779 O O   . SER A 1 244 ? 9.36782   38.12156  -6.10084  1.000 37.61778  ? 244 SER A O   1 
ATOM   1780 C CB  . SER A 1 244 ? 9.09396   36.62678  -9.03189  1.000 38.98444  ? 244 SER A CB  1 
ATOM   1781 O OG  . SER A 1 244 ? 8.69514   36.71495  -10.38528 1.000 45.28201  ? 244 SER A OG  1 
ATOM   1782 N N   . GLU A 1 245 ? 11.33152  37.44986  -6.97572  1.000 36.55735  ? 245 GLU A N   1 
ATOM   1783 C CA  . GLU A 1 245 ? 11.96476  37.35136  -5.66710  1.000 37.23292  ? 245 GLU A CA  1 
ATOM   1784 C C   . GLU A 1 245 ? 12.08564  38.72401  -5.01280  1.000 39.49365  ? 245 GLU A C   1 
ATOM   1785 O O   . GLU A 1 245 ? 11.83375  38.87314  -3.81108  1.000 39.72439  ? 245 GLU A O   1 
ATOM   1786 C CB  . GLU A 1 245 ? 13.33274  36.68037  -5.80867  1.000 35.21353  ? 245 GLU A CB  1 
ATOM   1787 C CG  . GLU A 1 245 ? 13.24846  35.21994  -6.27502  1.000 39.59481  ? 245 GLU A CG  1 
ATOM   1788 C CD  . GLU A 1 245 ? 14.59949  34.61536  -6.61237  1.000 44.27565  ? 245 GLU A CD  1 
ATOM   1789 O OE1 . GLU A 1 245 ? 15.57732  35.37336  -6.78938  1.000 42.98277  ? 245 GLU A OE1 1 
ATOM   1790 O OE2 . GLU A 1 245 ? 14.68637  33.37372  -6.70656  1.000 41.13998  ? 245 GLU A OE2 1 
ATOM   1791 N N   . LYS A 1 246 ? 12.44732  39.74245  -5.79415  1.000 38.78876  ? 246 LYS A N   1 
ATOM   1792 C CA  . LYS A 1 246 ? 12.57400  41.09405  -5.25275  1.000 41.58034  ? 246 LYS A CA  1 
ATOM   1793 C C   . LYS A 1 246 ? 11.25891  41.56654  -4.64069  1.000 38.99329  ? 246 LYS A C   1 
ATOM   1794 O O   . LYS A 1 246 ? 11.23378  42.09646  -3.52359  1.000 37.97175  ? 246 LYS A O   1 
ATOM   1795 C CB  . LYS A 1 246 ? 13.04101  42.04358  -6.35638  1.000 41.42077  ? 246 LYS A CB  1 
ATOM   1796 C CG  . LYS A 1 246 ? 13.46690  43.43530  -5.88808  1.000 42.70526  ? 246 LYS A CG  1 
ATOM   1797 C CD  . LYS A 1 246 ? 13.98129  44.25163  -7.06823  1.000 49.32082  ? 246 LYS A CD  1 
ATOM   1798 C CE  . LYS A 1 246 ? 14.52564  45.61510  -6.64200  1.000 47.73670  ? 246 LYS A CE  1 
ATOM   1799 N NZ  . LYS A 1 246 ? 13.47514  46.44978  -6.00452  1.000 41.51591  ? 246 LYS A NZ  1 
ATOM   1800 N N   . ASP A 1 247 ? 10.14755  41.36809  -5.35345  1.000 37.04404  ? 247 ASP A N   1 
ATOM   1801 C CA  . ASP A 1 247 ? 8.85432   41.77044  -4.81355  1.000 40.54714  ? 247 ASP A CA  1 
ATOM   1802 C C   . ASP A 1 247 ? 8.51806   40.99244  -3.54962  1.000 39.91340  ? 247 ASP A C   1 
ATOM   1803 O O   . ASP A 1 247 ? 7.96929   41.55281  -2.59134  1.000 35.59269  ? 247 ASP A O   1 
ATOM   1804 C CB  . ASP A 1 247 ? 7.75880   41.57498  -5.86117  1.000 40.46031  ? 247 ASP A CB  1 
ATOM   1805 C CG  . ASP A 1 247 ? 6.40134   42.03688  -5.36854  1.000 49.94922  ? 247 ASP A CG  1 
ATOM   1806 O OD1 . ASP A 1 247 ? 6.20049   43.26322  -5.23864  1.000 54.39621  ? 247 ASP A OD1 1 
ATOM   1807 O OD2 . ASP A 1 247 ? 5.53709   41.17621  -5.09625  1.000 59.35265  ? 247 ASP A OD2 1 
ATOM   1808 N N   . PHE A 1 248 ? 8.82831   39.69398  -3.53550  1.000 36.02886  ? 248 PHE A N   1 
ATOM   1809 C CA  . PHE A 1 248 ? 8.53967   38.86925  -2.36760  1.000 36.51884  ? 248 PHE A CA  1 
ATOM   1810 C C   . PHE A 1 248 ? 9.30305   39.36617  -1.14384  1.000 35.03018  ? 248 PHE A C   1 
ATOM   1811 O O   . PHE A 1 248 ? 8.73475   39.49717  -0.05211  1.000 35.18244  ? 248 PHE A O   1 
ATOM   1812 C CB  . PHE A 1 248 ? 8.88459   37.40844  -2.67592  1.000 34.00147  ? 248 PHE A CB  1 
ATOM   1813 C CG  . PHE A 1 248 ? 8.70405   36.48457  -1.51325  1.000 34.46471  ? 248 PHE A CG  1 
ATOM   1814 C CD1 . PHE A 1 248 ? 7.45385   36.28777  -0.95760  1.000 33.48695  ? 248 PHE A CD1 1 
ATOM   1815 C CD2 . PHE A 1 248 ? 9.78326   35.79281  -0.98682  1.000 36.08666  ? 248 PHE A CD2 1 
ATOM   1816 C CE1 . PHE A 1 248 ? 7.28496   35.43182  0.11496   1.000 32.31557  ? 248 PHE A CE1 1 
ATOM   1817 C CE2 . PHE A 1 248 ? 9.61913   34.93468  0.08427   1.000 32.08515  ? 248 PHE A CE2 1 
ATOM   1818 C CZ  . PHE A 1 248 ? 8.36952   34.75431  0.63375   1.000 34.43557  ? 248 PHE A CZ  1 
ATOM   1819 N N   . VAL A 1 249 ? 10.59660  39.65577  -1.31280  1.000 33.62249  ? 249 VAL A N   1 
ATOM   1820 C CA  . VAL A 1 249 ? 11.41440  40.12383  -0.19381  1.000 37.82297  ? 249 VAL A CA  1 
ATOM   1821 C C   . VAL A 1 249 ? 10.83456  41.40673  0.39530   1.000 38.02926  ? 249 VAL A C   1 
ATOM   1822 O O   . VAL A 1 249 ? 10.71533  41.55312  1.61802   1.000 37.02515  ? 249 VAL A O   1 
ATOM   1823 C CB  . VAL A 1 249 ? 12.87429  40.31827  -0.64161  1.000 35.89861  ? 249 VAL A CB  1 
ATOM   1824 C CG1 . VAL A 1 249 ? 13.67264  41.00712  0.45299   1.000 34.23854  ? 249 VAL A CG1 1 
ATOM   1825 C CG2 . VAL A 1 249 ? 13.50354  38.96844  -1.00482  1.000 35.79427  ? 249 VAL A CG2 1 
ATOM   1826 N N   . GLU A 1 250 ? 10.44714  42.34767  -0.46702  1.000 39.71445  ? 250 GLU A N   1 
ATOM   1827 C CA  . GLU A 1 250 ? 9.92190   43.61876  0.02538   1.000 39.48199  ? 250 GLU A CA  1 
ATOM   1828 C C   . GLU A 1 250 ? 8.60494   43.42510  0.76364   1.000 35.15054  ? 250 GLU A C   1 
ATOM   1829 O O   . GLU A 1 250 ? 8.38251   44.02883  1.81831   1.000 37.97629  ? 250 GLU A O   1 
ATOM   1830 C CB  . GLU A 1 250 ? 9.77185   44.60482  -1.13288  1.000 42.76934  ? 250 GLU A CB  1 
ATOM   1831 C CG  . GLU A 1 250 ? 11.11833  45.11654  -1.62720  1.000 52.46546  ? 250 GLU A CG  1 
ATOM   1832 C CD  . GLU A 1 250 ? 11.03345  45.89756  -2.92412  1.000 63.23586  ? 250 GLU A CD  1 
ATOM   1833 O OE1 . GLU A 1 250 ? 9.90882   46.07849  -3.44248  1.000 62.45799  ? 250 GLU A OE1 1 
ATOM   1834 O OE2 . GLU A 1 250 ? 12.10078  46.32367  -3.42607  1.000 56.72796  ? 250 GLU A OE2 1 
ATOM   1835 N N   . ARG A 1 251 ? 7.72904   42.56254  0.24599   1.000 41.73117  ? 251 ARG A N   1 
ATOM   1836 C CA  . ARG A 1 251 ? 6.49435   42.27382  0.96611   1.000 41.70122  ? 251 ARG A CA  1 
ATOM   1837 C C   . ARG A 1 251 ? 6.76275   41.53519  2.27302   1.000 40.89191  ? 251 ARG A C   1 
ATOM   1838 O O   . ARG A 1 251 ? 5.99445   41.68172  3.23083   1.000 40.52116  ? 251 ARG A O   1 
ATOM   1839 C CB  . ARG A 1 251 ? 5.54425   41.47565  0.07929   1.000 42.71266  ? 251 ARG A CB  1 
ATOM   1840 C CG  . ARG A 1 251 ? 5.09544   42.23569  -1.15491  1.000 45.34710  ? 251 ARG A CG  1 
ATOM   1841 C CD  . ARG A 1 251 ? 4.17921   41.38708  -2.01476  1.000 56.15252  ? 251 ARG A CD  1 
ATOM   1842 N NE  . ARG A 1 251 ? 3.75027   42.09913  -3.21448  1.000 52.24357  ? 251 ARG A NE  1 
ATOM   1843 C CZ  . ARG A 1 251 ? 2.70229   42.91609  -3.26251  1.000 61.56078  ? 251 ARG A CZ  1 
ATOM   1844 N NH1 . ARG A 1 251 ? 1.96785   43.12571  -2.17588  1.000 57.29697  ? 251 ARG A NH1 1 
ATOM   1845 N NH2 . ARG A 1 251 ? 2.38773   43.52379  -4.39864  1.000 64.69533  ? 251 ARG A NH2 1 
ATOM   1846 N N   . CYS A 1 252 ? 7.84303   40.74998  2.33708   1.000 40.04087  ? 252 CYS A N   1 
ATOM   1847 C CA  . CYS A 1 252 ? 8.20905   40.09181  3.58923   1.000 40.10768  ? 252 CYS A CA  1 
ATOM   1848 C C   . CYS A 1 252 ? 8.71289   41.09625  4.62244   1.000 38.74215  ? 252 CYS A C   1 
ATOM   1849 O O   . CYS A 1 252 ? 8.32997   41.03016  5.79691   1.000 37.99162  ? 252 CYS A O   1 
ATOM   1850 C CB  . CYS A 1 252 ? 9.26621   39.01738  3.33163   1.000 36.93812  ? 252 CYS A CB  1 
ATOM   1851 S SG  . CYS A 1 252 ? 8.60937   37.43756  2.76611   1.000 37.91445  ? 252 CYS A SG  1 
ATOM   1852 N N   . ASP A 1 253 ? 9.58842   42.01769  4.21084   1.000 43.06896  ? 253 ASP A N   1 
ATOM   1853 C CA  . ASP A 1 253 ? 10.05292  43.05750  5.12507   1.000 39.11173  ? 253 ASP A CA  1 
ATOM   1854 C C   . ASP A 1 253 ? 8.88783   43.88100  5.65252   1.000 40.14533  ? 253 ASP A C   1 
ATOM   1855 O O   . ASP A 1 253 ? 8.81283   44.17477  6.85166   1.000 40.99701  ? 253 ASP A O   1 
ATOM   1856 C CB  . ASP A 1 253 ? 11.07029  43.95772  4.42189   1.000 42.91828  ? 253 ASP A CB  1 
ATOM   1857 C CG  . ASP A 1 253 ? 12.41462  43.28971  4.25376   1.000 49.51210  ? 253 ASP A CG  1 
ATOM   1858 O OD1 . ASP A 1 253 ? 12.58938  42.18307  4.81413   1.000 50.81146  ? 253 ASP A OD1 1 
ATOM   1859 O OD2 . ASP A 1 253 ? 13.28898  43.86203  3.56299   1.000 52.42526  ? 253 ASP A OD2 1 
ATOM   1860 N N   . ARG A 1 254 ? 7.95797   44.24375  4.77094   1.000 40.69802  ? 254 ARG A N   1 
ATOM   1861 C CA  . ARG A 1 254 ? 6.80288   45.02554  5.18829   1.000 39.81053  ? 254 ARG A CA  1 
ATOM   1862 C C   . ARG A 1 254 ? 5.87019   44.20055  6.06736   1.000 43.64579  ? 254 ARG A C   1 
ATOM   1863 O O   . ARG A 1 254 ? 5.30416   44.71718  7.03869   1.000 43.15535  ? 254 ARG A O   1 
ATOM   1864 C CB  . ARG A 1 254 ? 6.08086   45.55497  3.95114   1.000 40.75461  ? 254 ARG A CB  1 
ATOM   1865 C CG  . ARG A 1 254 ? 5.09565   46.67998  4.21866   1.000 56.29555  ? 254 ARG A CG  1 
ATOM   1866 C CD  . ARG A 1 254 ? 5.03609   47.63611  3.03400   1.000 54.69781  ? 254 ARG A CD  1 
ATOM   1867 N NE  . ARG A 1 254 ? 5.04925   46.91867  1.76428   1.000 53.85673  ? 254 ARG A NE  1 
ATOM   1868 C CZ  . ARG A 1 254 ? 3.96061   46.46493  1.15465   1.000 58.72997  ? 254 ARG A CZ  1 
ATOM   1869 N NH1 . ARG A 1 254 ? 2.76775   46.66254  1.70224   1.000 61.21597  ? 254 ARG A NH1 1 
ATOM   1870 N NH2 . ARG A 1 254 ? 4.06510   45.81559  -0.00010  1.000 52.60232  ? 254 ARG A NH2 1 
ATOM   1871 N N   . ARG A 1 255 ? 5.70469   42.91333  5.74852   1.000 43.12988  ? 255 ARG A N   1 
ATOM   1872 C CA  . ARG A 1 255 ? 4.89152   42.03877  6.58986   1.000 41.46901  ? 255 ARG A CA  1 
ATOM   1873 C C   . ARG A 1 255 ? 5.47647   41.92144  7.99210   1.000 39.85372  ? 255 ARG A C   1 
ATOM   1874 O O   . ARG A 1 255 ? 4.74050   41.96797  8.98462   1.000 41.04181  ? 255 ARG A O   1 
ATOM   1875 C CB  . ARG A 1 255 ? 4.76535   40.65732  5.94067   1.000 44.80966  ? 255 ARG A CB  1 
ATOM   1876 C CG  . ARG A 1 255 ? 3.96775   39.63429  6.74944   1.000 39.53902  ? 255 ARG A CG  1 
ATOM   1877 C CD  . ARG A 1 255 ? 2.55116   40.11225  7.01949   1.000 40.79068  ? 255 ARG A CD  1 
ATOM   1878 N NE  . ARG A 1 255 ? 1.91858   40.67183  5.83022   1.000 39.28937  ? 255 ARG A NE  1 
ATOM   1879 C CZ  . ARG A 1 255 ? 1.22624   39.96456  4.94347   1.000 46.32064  ? 255 ARG A CZ  1 
ATOM   1880 N NH1 . ARG A 1 255 ? 1.08184   38.65375  5.10048   1.000 43.30783  ? 255 ARG A NH1 1 
ATOM   1881 N NH2 . ARG A 1 255 ? 0.68679   40.56541  3.89079   1.000 40.48673  ? 255 ARG A NH2 1 
ATOM   1882 N N   . ARG A 1 256 ? 6.79907   41.76516  8.09354   1.000 41.74304  ? 256 ARG A N   1 
ATOM   1883 C CA  . ARG A 1 256 ? 7.44249   41.69960  9.40319   1.000 42.06381  ? 256 ARG A CA  1 
ATOM   1884 C C   . ARG A 1 256 ? 7.15073   42.95230  10.21921  1.000 50.19477  ? 256 ARG A C   1 
ATOM   1885 O O   . ARG A 1 256 ? 6.77971   42.86940  11.39641  1.000 51.32977  ? 256 ARG A O   1 
ATOM   1886 C CB  . ARG A 1 256 ? 8.95194   41.51627  9.24567   1.000 41.12549  ? 256 ARG A CB  1 
ATOM   1887 C CG  . ARG A 1 256 ? 9.68205   41.38231  10.57786  1.000 43.95336  ? 256 ARG A CG  1 
ATOM   1888 C CD  . ARG A 1 256 ? 11.09105  41.95282  10.52963  1.000 53.13984  ? 256 ARG A CD  1 
ATOM   1889 N NE  . ARG A 1 256 ? 11.86960  41.42700  9.41275   1.000 63.17014  ? 256 ARG A NE  1 
ATOM   1890 C CZ  . ARG A 1 256 ? 12.30518  42.16088  8.39234   1.000 55.36020  ? 256 ARG A CZ  1 
ATOM   1891 N NH1 . ARG A 1 256 ? 12.04465  43.46307  8.34784   1.000 50.43583  ? 256 ARG A NH1 1 
ATOM   1892 N NH2 . ARG A 1 256 ? 13.00437  41.59237  7.41736   1.000 46.09346  ? 256 ARG A NH2 1 
ATOM   1893 N N   . GLU A 1 257 ? 7.30527   44.12710  9.60099   1.000 48.16033  ? 257 GLU A N   1 
ATOM   1894 C CA  . GLU A 1 257 ? 7.15360   45.37769  10.33735  1.000 49.89816  ? 257 GLU A CA  1 
ATOM   1895 C C   . GLU A 1 257 ? 5.72716   45.56670  10.82810  1.000 46.30274  ? 257 GLU A C   1 
ATOM   1896 O O   . GLU A 1 257 ? 5.51110   45.96840  11.97624  1.000 53.91182  ? 257 GLU A O   1 
ATOM   1897 C CB  . GLU A 1 257 ? 7.58956   46.55649  9.46961   1.000 42.73089  ? 257 GLU A CB  1 
ATOM   1898 C CG  . GLU A 1 257 ? 9.08035   46.58731  9.21572   1.000 49.47011  ? 257 GLU A CG  1 
ATOM   1899 C CD  . GLU A 1 257 ? 9.88218   46.38766  10.49189  1.000 65.77971  ? 257 GLU A CD  1 
ATOM   1900 O OE1 . GLU A 1 257 ? 9.55234   47.03610  11.51069  1.000 66.73657  ? 257 GLU A OE1 1 
ATOM   1901 O OE2 . GLU A 1 257 ? 10.83157  45.57141  10.48150  1.000 56.37156  ? 257 GLU A OE2 1 
ATOM   1902 N N   . ASN A 1 258 ? 4.74031   45.27213  9.98356   1.000 45.16521  ? 258 ASN A N   1 
ATOM   1903 C CA  . ASN A 1 258 ? 3.35387   45.39369  10.41922  1.000 46.30922  ? 258 ASN A CA  1 
ATOM   1904 C C   . ASN A 1 258 ? 3.01419   44.39060  11.51481  1.000 47.50139  ? 258 ASN A C   1 
ATOM   1905 O O   . ASN A 1 258 ? 2.17494   44.67825  12.37529  1.000 48.49890  ? 258 ASN A O   1 
ATOM   1906 C CB  . ASN A 1 258 ? 2.41530   45.22260  9.22728   1.000 44.22288  ? 258 ASN A CB  1 
ATOM   1907 C CG  . ASN A 1 258 ? 2.35768   46.46099  8.34433   1.000 46.89226  ? 258 ASN A CG  1 
ATOM   1908 O OD1 . ASN A 1 258 ? 1.41741   47.24445  8.42628   1.000 44.48434  ? 258 ASN A OD1 1 
ATOM   1909 N ND2 . ASN A 1 258 ? 3.36535   46.63967  7.49757   1.000 42.53737  ? 258 ASN A ND2 1 
ATOM   1910 N N   . LEU A 1 259 ? 3.64540   43.21351  11.50303  1.000 48.85469  ? 259 LEU A N   1 
ATOM   1911 C CA  . LEU A 1 259 ? 3.38125   42.23080  12.54958  1.000 51.81295  ? 259 LEU A CA  1 
ATOM   1912 C C   . LEU A 1 259 ? 3.99069   42.65026  13.88221  1.000 55.55292  ? 259 LEU A C   1 
ATOM   1913 O O   . LEU A 1 259 ? 3.49134   42.25383  14.94260  1.000 51.69266  ? 259 LEU A O   1 
ATOM   1914 C CB  . LEU A 1 259 ? 3.91033   40.85815  12.13467  1.000 47.94494  ? 259 LEU A CB  1 
ATOM   1915 C CG  . LEU A 1 259 ? 3.15424   40.10609  11.03648  1.000 48.42730  ? 259 LEU A CG  1 
ATOM   1916 C CD1 . LEU A 1 259 ? 3.87263   38.80484  10.68890  1.000 43.23765  ? 259 LEU A CD1 1 
ATOM   1917 C CD2 . LEU A 1 259 ? 1.71462   39.83281  11.44544  1.000 46.35688  ? 259 LEU A CD2 1 
ATOM   1918 N N   . LYS A 1 260 ? 5.06411   43.44538  13.84895  1.000 56.01281  ? 260 LYS A N   1 
ATOM   1919 C CA  . LYS A 1 260 ? 5.66152   43.94374  15.08441  1.000 56.20491  ? 260 LYS A CA  1 
ATOM   1920 C C   . LYS A 1 260 ? 4.66472   44.76573  15.89110  1.000 54.18342  ? 260 LYS A C   1 
ATOM   1921 O O   . LYS A 1 260 ? 4.66638   44.71897  17.12652  1.000 60.07670  ? 260 LYS A O   1 
ATOM   1922 C CB  . LYS A 1 260 ? 6.90065   44.78394  14.77128  1.000 51.84627  ? 260 LYS A CB  1 
ATOM   1923 C CG  . LYS A 1 260 ? 8.15918   43.98315  14.49711  1.000 56.69763  ? 260 LYS A CG  1 
ATOM   1924 C CD  . LYS A 1 260 ? 9.30772   44.88503  14.05306  1.000 60.73513  ? 260 LYS A CD  1 
ATOM   1925 C CE  . LYS A 1 260 ? 10.56140  44.07456  13.76227  1.000 56.95701  ? 260 LYS A CE  1 
ATOM   1926 N NZ  . LYS A 1 260 ? 11.62299  44.88289  13.09565  1.000 68.97703  ? 260 LYS A NZ  1 
ATOM   1927 N N   . ILE A 1 261 ? 3.79209   45.50992  15.21139  1.000 52.68386  ? 261 ILE A N   1 
ATOM   1928 C CA  . ILE A 1 261 ? 2.95025   46.50493  15.86530  1.000 55.14175  ? 261 ILE A CA  1 
ATOM   1929 C C   . ILE A 1 261 ? 1.55714   45.97031  16.18105  1.000 60.13462  ? 261 ILE A C   1 
ATOM   1930 O O   . ILE A 1 261 ? 0.67602   46.74471  16.56555  1.000 62.26598  ? 261 ILE A O   1 
ATOM   1931 C CB  . ILE A 1 261 ? 2.86477   47.79117  15.02889  1.000 51.30620  ? 261 ILE A CB  1 
ATOM   1932 C CG1 . ILE A 1 261 ? 2.10118   47.54155  13.73055  1.000 53.56260  ? 261 ILE A CG1 1 
ATOM   1933 C CG2 . ILE A 1 261 ? 4.26055   48.31237  14.71600  1.000 57.95599  ? 261 ILE A CG2 1 
ATOM   1934 C CD1 . ILE A 1 261 ? 2.00272   48.76923  12.83717  1.000 56.70500  ? 261 ILE A CD1 1 
ATOM   1935 N N   . VAL A 1 262 ? 1.33436   44.66794  16.03589  1.000 59.07560  ? 262 VAL A N   1 
ATOM   1936 C CA  . VAL A 1 262 ? 0.07352   44.04534  16.42321  1.000 57.09473  ? 262 VAL A CA  1 
ATOM   1937 C C   . VAL A 1 262 ? 0.26018   43.38836  17.78300  1.000 61.18635  ? 262 VAL A C   1 
ATOM   1938 O O   . VAL A 1 262 ? 1.18004   42.58183  17.97417  1.000 59.66378  ? 262 VAL A O   1 
ATOM   1939 C CB  . VAL A 1 262 ? -0.40117  43.02872  15.37294  1.000 52.50353  ? 262 VAL A CB  1 
ATOM   1940 C CG1 . VAL A 1 262 ? -1.58300  42.23402  15.90523  1.000 51.87828  ? 262 VAL A CG1 1 
ATOM   1941 C CG2 . VAL A 1 262 ? -0.78529  43.74443  14.08895  1.000 43.22412  ? 262 VAL A CG2 1 
ATOM   1942 N N   . GLN A 1 263 ? -0.59985  43.75148  18.73663  1.000 59.42849  ? 263 GLN A N   1 
ATOM   1943 C CA  . GLN A 1 263 ? -0.54906  43.19360  20.07817  1.000 60.42931  ? 263 GLN A CA  1 
ATOM   1944 C C   . GLN A 1 263 ? -1.70418  42.25610  20.38590  1.000 61.97778  ? 263 GLN A C   1 
ATOM   1945 O O   . GLN A 1 263 ? -1.59627  41.45874  21.32250  1.000 68.23909  ? 263 GLN A O   1 
ATOM   1946 C CB  . GLN A 1 263 ? -0.53434  44.31837  21.12569  1.000 66.18531  ? 263 GLN A CB  1 
ATOM   1947 C CG  . GLN A 1 263 ? 0.53163   45.38227  20.89021  1.000 65.04412  ? 263 GLN A CG  1 
ATOM   1948 C CD  . GLN A 1 263 ? 1.94470   44.84934  21.05908  1.000 71.29139  ? 263 GLN A CD  1 
ATOM   1949 O OE1 . GLN A 1 263 ? 2.15941   43.79480  21.66091  1.000 72.99030  ? 263 GLN A OE1 1 
ATOM   1950 N NE2 . GLN A 1 263 ? 2.91797   45.57950  20.52579  1.000 69.26495  ? 263 GLN A NE2 1 
ATOM   1951 N N   . ASP A 1 264 ? -2.79325  42.32746  19.62536  1.000 58.08854  ? 264 ASP A N   1 
ATOM   1952 C CA  . ASP A 1 264 ? -3.98155  41.51452  19.87190  1.000 62.79883  ? 264 ASP A CA  1 
ATOM   1953 C C   . ASP A 1 264 ? -3.86948  40.23470  19.04961  1.000 69.18991  ? 264 ASP A C   1 
ATOM   1954 O O   . ASP A 1 264 ? -4.09323  40.23987  17.83593  1.000 65.16435  ? 264 ASP A O   1 
ATOM   1955 C CB  . ASP A 1 264 ? -5.24165  42.30067  19.52854  1.000 64.24738  ? 264 ASP A CB  1 
ATOM   1956 C CG  . ASP A 1 264 ? -6.50510  41.60042  19.97693  1.000 74.06291  ? 264 ASP A CG  1 
ATOM   1957 O OD1 . ASP A 1 264 ? -6.60556  41.26988  21.17554  1.000 82.66947  ? 264 ASP A OD1 1 
ATOM   1958 O OD2 . ASP A 1 264 ? -7.40241  41.38877  19.13628  1.000 74.18903  ? 264 ASP A OD2 1 
ATOM   1959 N N   . PHE A 1 265 ? -3.52553  39.12991  19.71972  1.000 62.98226  ? 265 PHE A N   1 
ATOM   1960 C CA  . PHE A 1 265 ? -3.35411  37.85519  19.02700  1.000 62.21651  ? 265 PHE A CA  1 
ATOM   1961 C C   . PHE A 1 265 ? -4.63112  37.42681  18.31606  1.000 63.19482  ? 265 PHE A C   1 
ATOM   1962 O O   . PHE A 1 265 ? -4.57847  36.83919  17.22889  1.000 61.50399  ? 265 PHE A O   1 
ATOM   1963 C CB  . PHE A 1 265 ? -2.91190  36.77378  20.01429  1.000 64.43908  ? 265 PHE A CB  1 
ATOM   1964 C CG  . PHE A 1 265 ? -3.02868  35.37370  19.47177  1.000 67.75374  ? 265 PHE A CG  1 
ATOM   1965 C CD1 . PHE A 1 265 ? -2.01474  34.82726  18.70216  1.000 59.43246  ? 265 PHE A CD1 1 
ATOM   1966 C CD2 . PHE A 1 265 ? -4.15654  34.60618  19.72783  1.000 60.49810  ? 265 PHE A CD2 1 
ATOM   1967 C CE1 . PHE A 1 265 ? -2.12210  33.54571  18.20093  1.000 63.61788  ? 265 PHE A CE1 1 
ATOM   1968 C CE2 . PHE A 1 265 ? -4.26985  33.32526  19.22571  1.000 60.45164  ? 265 PHE A CE2 1 
ATOM   1969 C CZ  . PHE A 1 265 ? -3.25169  32.79434  18.46167  1.000 58.09612  ? 265 PHE A CZ  1 
ATOM   1970 N N   . ASN A 1 266 ? -5.78980  37.69752  18.91869  1.000 68.68657  ? 266 ASN A N   1 
ATOM   1971 C CA  . ASN A 1 266 ? -7.03956  37.24951  18.31540  1.000 68.85739  ? 266 ASN A CA  1 
ATOM   1972 C C   . ASN A 1 266 ? -7.33186  38.00528  17.02493  1.000 66.54669  ? 266 ASN A C   1 
ATOM   1973 O O   . ASN A 1 266 ? -7.87509  37.43040  16.07425  1.000 58.76055  ? 266 ASN A O   1 
ATOM   1974 C CB  . ASN A 1 266 ? -8.19188  37.40243  19.30576  1.000 68.02452  ? 266 ASN A CB  1 
ATOM   1975 C CG  . ASN A 1 266 ? -9.44271  36.68355  18.85043  1.000 76.08431  ? 266 ASN A CG  1 
ATOM   1976 O OD1 . ASN A 1 266 ? -9.53426  35.45727  18.93727  1.000 81.64860  ? 266 ASN A OD1 1 
ATOM   1977 N ND2 . ASN A 1 266 ? -10.41927 37.44308  18.36645  1.000 77.80889  ? 266 ASN A ND2 1 
ATOM   1978 N N   . SER A 1 267 ? -6.97328  39.29211  16.96869  1.000 62.77982  ? 267 SER A N   1 
ATOM   1979 C CA  . SER A 1 267 ? -7.12819  40.04432  15.72699  1.000 65.07168  ? 267 SER A CA  1 
ATOM   1980 C C   . SER A 1 267 ? -6.20337  39.51364  14.64052  1.000 59.00762  ? 267 SER A C   1 
ATOM   1981 O O   . SER A 1 267 ? -6.56476  39.52917  13.45744  1.000 51.38617  ? 267 SER A O   1 
ATOM   1982 C CB  . SER A 1 267 ? -6.86077  41.53070  15.96540  1.000 61.00001  ? 267 SER A CB  1 
ATOM   1983 O OG  . SER A 1 267 ? -5.47891  41.76867  16.17105  1.000 69.69913  ? 267 SER A OG  1 
ATOM   1984 N N   . LEU A 1 268 ? -5.01088  39.04909  15.02426  1.000 60.05002  ? 268 LEU A N   1 
ATOM   1985 C CA  . LEU A 1 268 ? -4.12565  38.37337  14.08076  1.000 56.03738  ? 268 LEU A CA  1 
ATOM   1986 C C   . LEU A 1 268 ? -4.83757  37.21837  13.39213  1.000 52.48185  ? 268 LEU A C   1 
ATOM   1987 O O   . LEU A 1 268 ? -4.86703  37.13735  12.15963  1.000 51.13957  ? 268 LEU A O   1 
ATOM   1988 C CB  . LEU A 1 268 ? -2.87554  37.86584  14.79916  1.000 53.28633  ? 268 LEU A CB  1 
ATOM   1989 C CG  . LEU A 1 268 ? -1.57919  38.61826  14.52385  1.000 62.36408  ? 268 LEU A CG  1 
ATOM   1990 C CD1 . LEU A 1 268 ? -0.40075  37.76757  14.95234  1.000 58.80030  ? 268 LEU A CD1 1 
ATOM   1991 C CD2 . LEU A 1 268 ? -1.48153  38.97810  13.04495  1.000 58.84584  ? 268 LEU A CD2 1 
ATOM   1992 N N   . THR A 1 269 ? -5.42759  36.31408  14.17815  1.000 52.03612  ? 269 THR A N   1 
ATOM   1993 C CA  . THR A 1 269 ? -6.08878  35.15780  13.58956  1.000 53.27583  ? 269 THR A CA  1 
ATOM   1994 C C   . THR A 1 269 ? -7.32556  35.54975  12.79600  1.000 50.66372  ? 269 THR A C   1 
ATOM   1995 O O   . THR A 1 269 ? -7.73207  34.80081  11.90343  1.000 52.46615  ? 269 THR A O   1 
ATOM   1996 C CB  . THR A 1 269 ? -6.45091  34.13700  14.67390  1.000 55.70763  ? 269 THR A CB  1 
ATOM   1997 O OG1 . THR A 1 269 ? -7.62225  34.56616  15.37868  1.000 62.28223  ? 269 THR A OG1 1 
ATOM   1998 C CG2 . THR A 1 269 ? -5.30025  33.99111  15.66283  1.000 51.58042  ? 269 THR A CG2 1 
ATOM   1999 N N   . GLN A 1 270 ? -7.92653  36.70578  13.09279  1.000 58.99491  ? 270 GLN A N   1 
ATOM   2000 C CA  . GLN A 1 270 ? -9.03392  37.20062  12.27888  1.000 55.79276  ? 270 GLN A CA  1 
ATOM   2001 C C   . GLN A 1 270 ? -8.53756  37.76377  10.95356  1.000 48.12614  ? 270 GLN A C   1 
ATOM   2002 O O   . GLN A 1 270 ? -9.18547  37.58349  9.91570   1.000 50.32197  ? 270 GLN A O   1 
ATOM   2003 C CB  . GLN A 1 270 ? -9.81966  38.26826  13.04155  1.000 60.32114  ? 270 GLN A CB  1 
ATOM   2004 C CG  . GLN A 1 270 ? -10.49025 37.75961  14.29437  1.000 58.98751  ? 270 GLN A CG  1 
ATOM   2005 C CD  . GLN A 1 270 ? -11.40744 36.59419  14.01438  1.000 68.37347  ? 270 GLN A CD  1 
ATOM   2006 O OE1 . GLN A 1 270 ? -12.44716 36.75052  13.37667  1.000 74.36590  ? 270 GLN A OE1 1 
ATOM   2007 N NE2 . GLN A 1 270 ? -11.02229 35.41084  14.47986  1.000 75.73656  ? 270 GLN A NE2 1 
ATOM   2008 N N   . SER A 1 271 ? -7.39437  38.45087  10.97600  1.000 52.07529  ? 271 SER A N   1 
ATOM   2009 C CA  . SER A 1 271 ? -6.81649  38.98146  9.74594   1.000 52.00139  ? 271 SER A CA  1 
ATOM   2010 C C   . SER A 1 271 ? -6.42331  37.85579  8.79754   1.000 49.28140  ? 271 SER A C   1 
ATOM   2011 O O   . SER A 1 271 ? -6.72801  37.90110  7.59950   1.000 52.53884  ? 271 SER A O   1 
ATOM   2012 C CB  . SER A 1 271 ? -5.60693  39.85717  10.07440  1.000 50.23144  ? 271 SER A CB  1 
ATOM   2013 O OG  . SER A 1 271 ? -5.96869  40.92924  10.92793  1.000 52.98762  ? 271 SER A OG  1 
ATOM   2014 N N   . TYR A 1 272 ? -5.75710  36.82846  9.31966   1.000 47.56751  ? 272 TYR A N   1 
ATOM   2015 C CA  . TYR A 1 272 ? -5.27226  35.70035  8.52331   1.000 43.91480  ? 272 TYR A CA  1 
ATOM   2016 C C   . TYR A 1 272 ? -5.97827  34.44132  9.00809   1.000 48.20887  ? 272 TYR A C   1 
ATOM   2017 O O   . TYR A 1 272 ? -5.43625  33.66830  9.80008   1.000 45.97950  ? 272 TYR A O   1 
ATOM   2018 C CB  . TYR A 1 272 ? -3.80490  35.58835  8.63589   1.000 42.35371  ? 272 TYR A CB  1 
ATOM   2019 C CG  . TYR A 1 272 ? -3.08413  36.84826  8.23045   1.000 43.90085  ? 272 TYR A CG  1 
ATOM   2020 C CD1 . TYR A 1 272 ? -2.80925  37.11056  6.89651   1.000 48.83018  ? 272 TYR A CD1 1 
ATOM   2021 C CD2 . TYR A 1 272 ? -2.67784  37.77377  9.17827   1.000 40.79521  ? 272 TYR A CD2 1 
ATOM   2022 C CE1 . TYR A 1 272 ? -2.15236  38.26176  6.51439   1.000 42.39392  ? 272 TYR A CE1 1 
ATOM   2023 C CE2 . TYR A 1 272 ? -2.01268  38.92788  8.80717   1.000 45.72073  ? 272 TYR A CE2 1 
ATOM   2024 C CZ  . TYR A 1 272 ? -1.75516  39.16697  7.47216   1.000 45.23587  ? 272 TYR A CZ  1 
ATOM   2025 O OH  . TYR A 1 272 ? -1.08626  40.30771  7.09167   1.000 44.56681  ? 272 TYR A OH  1 
ATOM   2026 N N   . GLU A 1 273 ? -7.19593  34.23628  8.50529   1.000 43.43741  ? 273 GLU A N   1 
ATOM   2027 C CA  . GLU A 1 273 ? -8.05818  33.17904  9.00643   1.000 51.40032  ? 273 GLU A CA  1 
ATOM   2028 C C   . GLU A 1 273 ? -7.55098  31.79913  8.58834   1.000 51.06037  ? 273 GLU A C   1 
ATOM   2029 O O   . GLU A 1 273 ? -7.16727  31.57239  7.43668   1.000 41.34707  ? 273 GLU A O   1 
ATOM   2030 C CB  . GLU A 1 273 ? -9.48589  33.40436  8.50646   1.000 53.17413  ? 273 GLU A CB  1 
ATOM   2031 C CG  . GLU A 1 273 ? -10.56855 32.92641  9.45190   1.000 60.06896  ? 273 GLU A CG  1 
ATOM   2032 C CD  . GLU A 1 273 ? -11.22696 31.65384  8.97006   1.000 67.10292  ? 273 GLU A CD  1 
ATOM   2033 O OE1 . GLU A 1 273 ? -11.03672 30.59786  9.61558   1.000 69.30309  ? 273 GLU A OE1 1 
ATOM   2034 O OE2 . GLU A 1 273 ? -11.92806 31.71389  7.93590   1.000 71.01145  ? 273 GLU A OE2 1 
ATOM   2035 N N   . TRP A 1 274 ? -7.56515  30.86888  9.54458   1.000 51.00609  ? 274 TRP A N   1 
ATOM   2036 C CA  . TRP A 1 274 ? -6.99236  29.54644  9.31949   1.000 45.12316  ? 274 TRP A CA  1 
ATOM   2037 C C   . TRP A 1 274 ? -7.74535  28.78049  8.23581   1.000 46.30841  ? 274 TRP A C   1 
ATOM   2038 O O   . TRP A 1 274 ? -7.13838  28.26761  7.28795   1.000 43.34299  ? 274 TRP A O   1 
ATOM   2039 C CB  . TRP A 1 274 ? -6.99000  28.75612  10.62441  1.000 53.70850  ? 274 TRP A CB  1 
ATOM   2040 C CG  . TRP A 1 274 ? -6.59304  27.34575  10.40665  1.000 55.62030  ? 274 TRP A CG  1 
ATOM   2041 C CD1 . TRP A 1 274 ? -7.39789  26.24050  10.45867  1.000 50.49051  ? 274 TRP A CD1 1 
ATOM   2042 C CD2 . TRP A 1 274 ? -5.29115  26.88173  10.06103  1.000 44.85596  ? 274 TRP A CD2 1 
ATOM   2043 N NE1 . TRP A 1 274 ? -6.66327  25.11263  10.18376  1.000 51.70223  ? 274 TRP A NE1 1 
ATOM   2044 C CE2 . TRP A 1 274 ? -5.36682  25.48145  9.93495   1.000 44.38653  ? 274 TRP A CE2 1 
ATOM   2045 C CE3 . TRP A 1 274 ? -4.06191  27.51474  9.85111   1.000 47.67197  ? 274 TRP A CE3 1 
ATOM   2046 C CZ2 . TRP A 1 274 ? -4.26305  24.70552  9.61068   1.000 44.86449  ? 274 TRP A CZ2 1 
ATOM   2047 C CZ3 . TRP A 1 274 ? -2.96850  26.74169  9.52793   1.000 49.06997  ? 274 TRP A CZ3 1 
ATOM   2048 C CH2 . TRP A 1 274 ? -3.07660  25.35098  9.41046   1.000 42.94751  ? 274 TRP A CH2 1 
ATOM   2049 N N   . ALA A 1 275 ? -9.07117  28.67382  8.37119   1.000 47.25457  ? 275 ALA A N   1 
ATOM   2050 C CA  . ALA A 1 275 ? -9.86078  27.94454  7.38340   1.000 47.65075  ? 275 ALA A CA  1 
ATOM   2051 C C   . ALA A 1 275 ? -9.70332  28.53918  5.99086   1.000 49.54576  ? 275 ALA A C   1 
ATOM   2052 O O   . ALA A 1 275 ? -9.73114  27.80647  4.99451   1.000 47.04223  ? 275 ALA A O   1 
ATOM   2053 C CB  . ALA A 1 275 ? -11.33447 27.93245  7.79127   1.000 56.73075  ? 275 ALA A CB  1 
ATOM   2054 N N   . GLN A 1 276 ? -9.53267  29.86038  5.90567   1.000 46.63808  ? 276 GLN A N   1 
ATOM   2055 C CA  . GLN A 1 276 ? -9.28587  30.50518  4.62154   1.000 48.07239  ? 276 GLN A CA  1 
ATOM   2056 C C   . GLN A 1 276 ? -7.91022  30.14121  4.07542   1.000 42.03152  ? 276 GLN A C   1 
ATOM   2057 O O   . GLN A 1 276 ? -7.75406  29.91872  2.86949   1.000 40.45892  ? 276 GLN A O   1 
ATOM   2058 C CB  . GLN A 1 276 ? -9.42591  32.02148  4.77047   1.000 48.88536  ? 276 GLN A CB  1 
ATOM   2059 C CG  . GLN A 1 276 ? -8.93794  32.82741  3.57933   1.000 51.85911  ? 276 GLN A CG  1 
ATOM   2060 C CD  . GLN A 1 276 ? -9.98273  32.97524  2.49209   1.000 65.30163  ? 276 GLN A CD  1 
ATOM   2061 O OE1 . GLN A 1 276 ? -10.86621 32.12931  2.33653   1.000 57.67199  ? 276 GLN A OE1 1 
ATOM   2062 N NE2 . GLN A 1 276 ? -9.88993  34.06470  1.73352   1.000 67.95645  ? 276 GLN A NE2 1 
ATOM   2063 N N   . PHE A 1 277 ? -6.89968  30.08223  4.94613   1.000 43.98702  ? 277 PHE A N   1 
ATOM   2064 C CA  . PHE A 1 277 ? -5.56544  29.68941  4.50552   1.000 38.38995  ? 277 PHE A CA  1 
ATOM   2065 C C   . PHE A 1 277 ? -5.56822  28.27369  3.94199   1.000 38.09200  ? 277 PHE A C   1 
ATOM   2066 O O   . PHE A 1 277 ? -5.05418  28.02984  2.84476   1.000 38.38350  ? 277 PHE A O   1 
ATOM   2067 C CB  . PHE A 1 277 ? -4.57457  29.80347  5.66212   1.000 38.10334  ? 277 PHE A CB  1 
ATOM   2068 C CG  . PHE A 1 277 ? -3.25146  29.15735  5.38152   1.000 38.91810  ? 277 PHE A CG  1 
ATOM   2069 C CD1 . PHE A 1 277 ? -2.30668  29.79780  4.59646   1.000 39.39652  ? 277 PHE A CD1 1 
ATOM   2070 C CD2 . PHE A 1 277 ? -2.94804  27.90646  5.89984   1.000 43.61518  ? 277 PHE A CD2 1 
ATOM   2071 C CE1 . PHE A 1 277 ? -1.08115  29.20730  4.33496   1.000 32.51792  ? 277 PHE A CE1 1 
ATOM   2072 C CE2 . PHE A 1 277 ? -1.72559  27.30783  5.63770   1.000 38.93951  ? 277 PHE A CE2 1 
ATOM   2073 C CZ  . PHE A 1 277 ? -0.79266  27.96098  4.85274   1.000 36.34722  ? 277 PHE A CZ  1 
ATOM   2074 N N   . ILE A 1 278 ? -6.15226  27.32448  4.67978   1.000 38.16159  ? 278 ILE A N   1 
ATOM   2075 C CA  . ILE A 1 278 ? -6.16199  25.93543  4.22940   1.000 40.08436  ? 278 ILE A CA  1 
ATOM   2076 C C   . ILE A 1 278 ? -6.90549  25.80466  2.90774   1.000 38.96407  ? 278 ILE A C   1 
ATOM   2077 O O   . ILE A 1 278 ? -6.48720  25.05631  2.01500   1.000 39.20303  ? 278 ILE A O   1 
ATOM   2078 C CB  . ILE A 1 278 ? -6.76698  25.02290  5.31504   1.000 40.52040  ? 278 ILE A CB  1 
ATOM   2079 C CG1 . ILE A 1 278 ? -5.79757  24.88417  6.48597   1.000 41.92593  ? 278 ILE A CG1 1 
ATOM   2080 C CG2 . ILE A 1 278 ? -7.10133  23.65680  4.74554   1.000 37.67359  ? 278 ILE A CG2 1 
ATOM   2081 C CD1 . ILE A 1 278 ? -4.43626  24.34259  6.08253   1.000 40.79439  ? 278 ILE A CD1 1 
ATOM   2082 N N   . ARG A 1 279 ? -8.01605  26.52906  2.75595   1.000 42.83947  ? 279 ARG A N   1 
ATOM   2083 C CA  . ARG A 1 279 ? -8.77011  26.45793  1.50672   1.000 41.66925  ? 279 ARG A CA  1 
ATOM   2084 C C   . ARG A 1 279 ? -7.92869  26.94142  0.33232   1.000 35.33736  ? 279 ARG A C   1 
ATOM   2085 O O   . ARG A 1 279 ? -7.87703  26.29272  -0.71834  1.000 37.87523  ? 279 ARG A O   1 
ATOM   2086 C CB  . ARG A 1 279 ? -10.06412 27.27067  1.61822   1.000 46.55661  ? 279 ARG A CB  1 
ATOM   2087 C CG  . ARG A 1 279 ? -11.32167 26.41250  1.63973   1.000 55.35514  ? 279 ARG A CG  1 
ATOM   2088 C CD  . ARG A 1 279 ? -12.59954 27.24608  1.62987   1.000 68.75804  ? 279 ARG A CD  1 
ATOM   2089 N NE  . ARG A 1 279 ? -12.80845 27.97399  2.87937   1.000 69.19374  ? 279 ARG A NE  1 
ATOM   2090 C CZ  . ARG A 1 279 ? -12.63431 29.28446  3.02074   1.000 68.78137  ? 279 ARG A CZ  1 
ATOM   2091 N NH1 . ARG A 1 279 ? -12.25155 30.01772  1.98204   1.000 58.79599  ? 279 ARG A NH1 1 
ATOM   2092 N NH2 . ARG A 1 279 ? -12.84857 29.86221  4.19853   1.000 58.82480  ? 279 ARG A NH2 1 
ATOM   2093 N N   . GLU A 1 280 ? -7.25303  28.08117  0.49738   1.000 42.82381  ? 280 GLU A N   1 
ATOM   2094 C CA  . GLU A 1 280 ? -6.42736  28.61144  -0.58330  1.000 38.73887  ? 280 GLU A CA  1 
ATOM   2095 C C   . GLU A 1 280 ? -5.23403  27.70709  -0.86339  1.000 36.29135  ? 280 GLU A C   1 
ATOM   2096 O O   . GLU A 1 280 ? -4.81005  27.57274  -2.01671  1.000 37.63792  ? 280 GLU A O   1 
ATOM   2097 C CB  . GLU A 1 280 ? -5.96624  30.03089  -0.24831  1.000 38.29218  ? 280 GLU A CB  1 
ATOM   2098 C CG  . GLU A 1 280 ? -7.10390  31.04453  -0.23889  1.000 41.42699  ? 280 GLU A CG  1 
ATOM   2099 C CD  . GLU A 1 280 ? -6.67313  32.42704  0.21964   1.000 49.69779  ? 280 GLU A CD  1 
ATOM   2100 O OE1 . GLU A 1 280 ? -5.48844  32.60525  0.57208   1.000 49.46619  ? 280 GLU A OE1 1 
ATOM   2101 O OE2 . GLU A 1 280 ? -7.52709  33.33773  0.22648   1.000 61.66589  ? 280 GLU A OE2 1 
ATOM   2102 N N   . LEU A 1 281 ? -4.67969  27.08040  0.17346   1.000 38.14888  ? 281 LEU A N   1 
ATOM   2103 C CA  . LEU A 1 281 ? -3.57377  26.15113  -0.03757  1.000 35.25165  ? 281 LEU A CA  1 
ATOM   2104 C C   . LEU A 1 281 ? -4.02250  24.94352  -0.85490  1.000 33.84805  ? 281 LEU A C   1 
ATOM   2105 O O   . LEU A 1 281 ? -3.33843  24.52318  -1.79499  1.000 36.03246  ? 281 LEU A O   1 
ATOM   2106 C CB  . LEU A 1 281 ? -2.99928  25.70724  1.30632   1.000 30.68547  ? 281 LEU A CB  1 
ATOM   2107 C CG  . LEU A 1 281 ? -1.98632  24.56215  1.25246   1.000 31.19097  ? 281 LEU A CG  1 
ATOM   2108 C CD1 . LEU A 1 281 ? -0.75322  24.97031  0.45551   1.000 31.06102  ? 281 LEU A CD1 1 
ATOM   2109 C CD2 . LEU A 1 281 ? -1.61025  24.13410  2.66677   1.000 32.07624  ? 281 LEU A CD2 1 
ATOM   2110 N N   . LEU A 1 282 ? -5.17674  24.37065  -0.51176  1.000 35.76449  ? 282 LEU A N   1 
ATOM   2111 C CA  . LEU A 1 282 ? -5.67002  23.22319  -1.26731  1.000 36.35950  ? 282 LEU A CA  1 
ATOM   2112 C C   . LEU A 1 282 ? -6.03632  23.61681  -2.69262  1.000 34.73470  ? 282 LEU A C   1 
ATOM   2113 O O   . LEU A 1 282 ? -5.69353  22.90766  -3.64742  1.000 37.81203  ? 282 LEU A O   1 
ATOM   2114 C CB  . LEU A 1 282 ? -6.86219  22.59600  -0.54697  1.000 33.04050  ? 282 LEU A CB  1 
ATOM   2115 C CG  . LEU A 1 282 ? -6.49508  21.88094  0.75612   1.000 36.55864  ? 282 LEU A CG  1 
ATOM   2116 C CD1 . LEU A 1 282 ? -7.73986  21.44617  1.51259   1.000 38.59418  ? 282 LEU A CD1 1 
ATOM   2117 C CD2 . LEU A 1 282 ? -5.58993  20.69027  0.47303   1.000 44.79215  ? 282 LEU A CD2 1 
ATOM   2118 N N   . ASP A 1 283 ? -6.72047  24.74966  -2.85817  1.000 37.71459  ? 283 ASP A N   1 
ATOM   2119 C CA  . ASP A 1 283 ? -7.04858  25.22072  -4.20016  1.000 39.71745  ? 283 ASP A CA  1 
ATOM   2120 C C   . ASP A 1 283 ? -5.78907  25.49499  -5.01503  1.000 38.52638  ? 283 ASP A C   1 
ATOM   2121 O O   . ASP A 1 283 ? -5.75107  25.22534  -6.22092  1.000 35.66827  ? 283 ASP A O   1 
ATOM   2122 C CB  . ASP A 1 283 ? -7.91961  26.47199  -4.11499  1.000 45.44708  ? 283 ASP A CB  1 
ATOM   2123 C CG  . ASP A 1 283 ? -8.35678  26.96227  -5.47436  1.000 58.67210  ? 283 ASP A CG  1 
ATOM   2124 O OD1 . ASP A 1 283 ? -8.95996  26.15858  -6.21853  1.000 64.39078  ? 283 ASP A OD1 1 
ATOM   2125 O OD2 . ASP A 1 283 ? -8.09883  28.14362  -5.79635  1.000 62.31675  ? 283 ASP A OD2 1 
ATOM   2126 N N   . TYR A 1 284 ? -4.74791  26.03382  -4.37455  1.000 36.31072  ? 284 TYR A N   1 
ATOM   2127 C CA  . TYR A 1 284 ? -3.46993  26.20602  -5.05693  1.000 33.51900  ? 284 TYR A CA  1 
ATOM   2128 C C   . TYR A 1 284 ? -2.95155  24.87506  -5.59187  1.000 34.82009  ? 284 TYR A C   1 
ATOM   2129 O O   . TYR A 1 284 ? -2.55484  24.77279  -6.75818  1.000 34.46518  ? 284 TYR A O   1 
ATOM   2130 C CB  . TYR A 1 284 ? -2.44499  26.83632  -4.10665  1.000 34.13187  ? 284 TYR A CB  1 
ATOM   2131 C CG  . TYR A 1 284 ? -1.09392  27.08962  -4.74773  1.000 34.79527  ? 284 TYR A CG  1 
ATOM   2132 C CD1 . TYR A 1 284 ? -0.16175  26.06485  -4.89048  1.000 37.78782  ? 284 TYR A CD1 1 
ATOM   2133 C CD2 . TYR A 1 284 ? -0.75103  28.35159  -5.21235  1.000 39.12872  ? 284 TYR A CD2 1 
ATOM   2134 C CE1 . TYR A 1 284 ? 1.07164   26.28807  -5.48138  1.000 36.44765  ? 284 TYR A CE1 1 
ATOM   2135 C CE2 . TYR A 1 284 ? 0.48284   28.58810  -5.80237  1.000 39.88748  ? 284 TYR A CE2 1 
ATOM   2136 C CZ  . TYR A 1 284 ? 1.38713   27.54862  -5.93493  1.000 45.42104  ? 284 TYR A CZ  1 
ATOM   2137 O OH  . TYR A 1 284 ? 2.60710   27.76553  -6.52544  1.000 42.17524  ? 284 TYR A OH  1 
ATOM   2138 N N   . CYS A 1 285 ? -2.92619  23.84484  -4.74086  1.000 36.67750  ? 285 CYS A N   1 
ATOM   2139 C CA  . CYS A 1 285 ? -2.35687  22.56503  -5.15376  1.000 38.20503  ? 285 CYS A CA  1 
ATOM   2140 C C   . CYS A 1 285 ? -3.13716  21.96075  -6.31137  1.000 34.50853  ? 285 CYS A C   1 
ATOM   2141 O O   . CYS A 1 285 ? -2.54716  21.36159  -7.21773  1.000 36.93578  ? 285 CYS A O   1 
ATOM   2142 C CB  . CYS A 1 285 ? -2.31220  21.59857  -3.97045  1.000 32.12458  ? 285 CYS A CB  1 
ATOM   2143 S SG  . CYS A 1 285 ? -1.20231  22.15308  -2.65347  1.000 35.49204  ? 285 CYS A SG  1 
ATOM   2144 N N   . ASN A 1 286 ? -4.46346  22.11126  -6.29666  1.000 36.15879  ? 286 ASN A N   1 
ATOM   2145 C CA  . ASN A 1 286 ? -5.29240  21.61838  -7.39351  1.000 39.08899  ? 286 ASN A CA  1 
ATOM   2146 C C   . ASN A 1 286 ? -4.89488  22.27353  -8.71132  1.000 43.62385  ? 286 ASN A C   1 
ATOM   2147 O O   . ASN A 1 286 ? -4.61462  21.58921  -9.70318  1.000 42.23721  ? 286 ASN A O   1 
ATOM   2148 C CB  . ASN A 1 286 ? -6.76559  21.88144  -7.07409  1.000 36.50629  ? 286 ASN A CB  1 
ATOM   2149 C CG  . ASN A 1 286 ? -7.71064  21.33957  -8.13310  1.000 43.99530  ? 286 ASN A CG  1 
ATOM   2150 O OD1 . ASN A 1 286 ? -7.38056  20.41219  -8.86890  1.000 43.54158  ? 286 ASN A OD1 1 
ATOM   2151 N ND2 . ASN A 1 286 ? -8.90128  21.91621  -8.20368  1.000 46.17828  ? 286 ASN A ND2 1 
ATOM   2152 N N   . LYS A 1 287 ? -4.83422  23.60564  -8.72826  1.000 39.84377  ? 287 LYS A N   1 
ATOM   2153 C CA  . LYS A 1 287 ? -4.57246  24.34049  -9.95740  1.000 37.91636  ? 287 LYS A CA  1 
ATOM   2154 C C   . LYS A 1 287 ? -3.12223  24.25652  -10.41287 1.000 40.59425  ? 287 LYS A C   1 
ATOM   2155 O O   . LYS A 1 287 ? -2.84836  24.47379  -11.59644 1.000 48.77793  ? 287 LYS A O   1 
ATOM   2156 C CB  . LYS A 1 287 ? -4.98746  25.80193  -9.77531  1.000 39.96692  ? 287 LYS A CB  1 
ATOM   2157 C CG  . LYS A 1 287 ? -6.49080  25.95477  -9.59161  1.000 52.91530  ? 287 LYS A CG  1 
ATOM   2158 C CD  . LYS A 1 287 ? -6.89690  27.33589  -9.11874  1.000 66.80908  ? 287 LYS A CD  1 
ATOM   2159 C CE  . LYS A 1 287 ? -8.41761  27.44594  -9.07264  1.000 73.50121  ? 287 LYS A CE  1 
ATOM   2160 N NZ  . LYS A 1 287 ? -8.89572  28.73980  -8.51369  1.000 72.53393  ? 287 LYS A NZ  1 
ATOM   2161 N N   . ASN A 1 288 ? -2.18906  23.93491  -9.51776  1.000 38.84090  ? 288 ASN A N   1 
ATOM   2162 C CA  . ASN A 1 288 ? -0.77617  23.87669  -9.86574  1.000 37.59324  ? 288 ASN A CA  1 
ATOM   2163 C C   . ASN A 1 288 ? -0.19757  22.46827  -9.75611  1.000 36.31318  ? 288 ASN A C   1 
ATOM   2164 O O   . ASN A 1 288 ? 1.02666   22.30889  -9.73155  1.000 39.94901  ? 288 ASN A O   1 
ATOM   2165 C CB  . ASN A 1 288 ? 0.01004   24.84771  -8.98870  1.000 36.61377  ? 288 ASN A CB  1 
ATOM   2166 C CG  . ASN A 1 288 ? -0.34013  26.28838  -9.27409  1.000 39.07650  ? 288 ASN A CG  1 
ATOM   2167 O OD1 . ASN A 1 288 ? 0.07512   26.83793  -10.28751 1.000 41.51273  ? 288 ASN A OD1 1 
ATOM   2168 N ND2 . ASN A 1 288 ? -1.11066  26.90736  -8.38720  1.000 34.86804  ? 288 ASN A ND2 1 
ATOM   2169 N N   . MET A 1 289 ? -1.05062  21.44158  -9.72674  1.000 36.11365  ? 289 MET A N   1 
ATOM   2170 C CA  . MET A 1 289 ? -0.56659  20.08319  -9.47397  1.000 36.40819  ? 289 MET A CA  1 
ATOM   2171 C C   . MET A 1 289 ? 0.41043   19.62068  -10.55060 1.000 36.69004  ? 289 MET A C   1 
ATOM   2172 O O   . MET A 1 289 ? 1.41024   18.95771  -10.24885 1.000 36.16317  ? 289 MET A O   1 
ATOM   2173 C CB  . MET A 1 289 ? -1.74653  19.11656  -9.36286  1.000 37.56380  ? 289 MET A CB  1 
ATOM   2174 C CG  . MET A 1 289 ? -1.34328  17.69685  -8.93166  1.000 39.58311  ? 289 MET A CG  1 
ATOM   2175 S SD  . MET A 1 289 ? -0.76932  17.59584  -7.21381  1.000 35.20125  ? 289 MET A SD  1 
ATOM   2176 C CE  . MET A 1 289 ? -2.25400  18.13750  -6.35625  1.000 29.19982  ? 289 MET A CE  1 
ATOM   2177 N N   . GLY A 1 290 ? 0.14168   19.95922  -11.81200 1.000 36.08540  ? 290 GLY A N   1 
ATOM   2178 C CA  . GLY A 1 290 ? 1.07180   19.60312  -12.86948 1.000 35.44517  ? 290 GLY A CA  1 
ATOM   2179 C C   . GLY A 1 290 ? 2.44701   20.20923  -12.66174 1.000 41.12902  ? 290 GLY A C   1 
ATOM   2180 O O   . GLY A 1 290 ? 3.46523   19.53656  -12.83323 1.000 43.04626  ? 290 GLY A O   1 
ATOM   2181 N N   . LEU A 1 291 ? 2.49593   21.48419  -12.27687 1.000 39.34804  ? 291 LEU A N   1 
ATOM   2182 C CA  . LEU A 1 291 ? 3.77997   22.12765  -12.02918 1.000 44.10515  ? 291 LEU A CA  1 
ATOM   2183 C C   . LEU A 1 291 ? 4.49564   21.48578  -10.84392 1.000 40.40642  ? 291 LEU A C   1 
ATOM   2184 O O   . LEU A 1 291 ? 5.69624   21.20208  -10.91264 1.000 43.54069  ? 291 LEU A O   1 
ATOM   2185 C CB  . LEU A 1 291 ? 3.57753   23.62448  -11.79891 1.000 51.35632  ? 291 LEU A CB  1 
ATOM   2186 C CG  . LEU A 1 291 ? 4.80302   24.50805  -12.06090 1.000 60.68609  ? 291 LEU A CG  1 
ATOM   2187 C CD1 . LEU A 1 291 ? 4.38866   25.87288  -12.60349 1.000 54.74898  ? 291 LEU A CD1 1 
ATOM   2188 C CD2 . LEU A 1 291 ? 5.65336   24.66878  -10.80580 1.000 58.58492  ? 291 LEU A CD2 1 
ATOM   2189 N N   . ILE A 1 292 ? 3.76874   21.23663  -9.75007  1.000 42.06748  ? 292 ILE A N   1 
ATOM   2190 C CA  . ILE A 1 292 ? 4.38400   20.65910  -8.55536  1.000 39.64259  ? 292 ILE A CA  1 
ATOM   2191 C C   . ILE A 1 292 ? 4.95369   19.27458  -8.85171  1.000 37.32047  ? 292 ILE A C   1 
ATOM   2192 O O   . ILE A 1 292 ? 6.09169   18.95737  -8.48086  1.000 38.43113  ? 292 ILE A O   1 
ATOM   2193 C CB  . ILE A 1 292 ? 3.37098   20.60436  -7.39636  1.000 36.06030  ? 292 ILE A CB  1 
ATOM   2194 C CG1 . ILE A 1 292 ? 2.88540   22.00604  -7.04388  1.000 35.12262  ? 292 ILE A CG1 1 
ATOM   2195 C CG2 . ILE A 1 292 ? 3.99539   19.92151  -6.18339  1.000 28.36846  ? 292 ILE A CG2 1 
ATOM   2196 C CD1 . ILE A 1 292 ? 1.65543   22.00563  -6.15249  1.000 31.55576  ? 292 ILE A CD1 1 
ATOM   2197 N N   . ILE A 1 293 ? 4.17830   18.42893  -9.52203  1.000 34.93409  ? 293 ILE A N   1 
ATOM   2198 C CA  . ILE A 1 293 ? 4.58380   17.03758  -9.69492  1.000 34.30931  ? 293 ILE A CA  1 
ATOM   2199 C C   . ILE A 1 293 ? 5.49547   16.85938  -10.90261 1.000 40.60609  ? 293 ILE A C   1 
ATOM   2200 O O   . ILE A 1 293 ? 6.50667   16.15668  -10.82322 1.000 37.49101  ? 293 ILE A O   1 
ATOM   2201 C CB  . ILE A 1 293 ? 3.34315   16.12940  -9.78798  1.000 37.09184  ? 293 ILE A CB  1 
ATOM   2202 C CG1 . ILE A 1 293 ? 2.43742   16.33009  -8.56722  1.000 31.98822  ? 293 ILE A CG1 1 
ATOM   2203 C CG2 . ILE A 1 293 ? 3.75947   14.67040  -9.93302  1.000 33.81083  ? 293 ILE A CG2 1 
ATOM   2204 C CD1 . ILE A 1 293 ? 3.11423   16.12360  -7.23629  1.000 28.95878  ? 293 ILE A CD1 1 
ATOM   2205 N N   . TRP A 1 294 ? 5.16641   17.48603  -12.03062 1.000 43.61247  ? 294 TRP A N   1 
ATOM   2206 C CA  . TRP A 1 294 ? 5.91949   17.28186  -13.26146 1.000 43.39173  ? 294 TRP A CA  1 
ATOM   2207 C C   . TRP A 1 294 ? 6.97232   18.35224  -13.52355 1.000 50.38920  ? 294 TRP A C   1 
ATOM   2208 O O   . TRP A 1 294 ? 7.90513   18.10169  -14.29633 1.000 53.19670  ? 294 TRP A O   1 
ATOM   2209 C CB  . TRP A 1 294 ? 4.96383   17.21923  -14.45940 1.000 46.20200  ? 294 TRP A CB  1 
ATOM   2210 C CG  . TRP A 1 294 ? 4.06511   16.01603  -14.47029 1.000 44.46712  ? 294 TRP A CG  1 
ATOM   2211 C CD1 . TRP A 1 294 ? 4.37899   14.74900  -14.06736 1.000 41.86329  ? 294 TRP A CD1 1 
ATOM   2212 C CD2 . TRP A 1 294 ? 2.69905   15.97448  -14.89951 1.000 42.93461  ? 294 TRP A CD2 1 
ATOM   2213 N NE1 . TRP A 1 294 ? 3.29192   13.91846  -14.22840 1.000 40.20351  ? 294 TRP A NE1 1 
ATOM   2214 C CE2 . TRP A 1 294 ? 2.24874   14.64826  -14.73607 1.000 44.81611  ? 294 TRP A CE2 1 
ATOM   2215 C CE3 . TRP A 1 294 ? 1.81198   16.93223  -15.40805 1.000 46.52669  ? 294 TRP A CE3 1 
ATOM   2216 C CZ2 . TRP A 1 294 ? 0.95000   14.25276  -15.06694 1.000 44.49842  ? 294 TRP A CZ2 1 
ATOM   2217 C CZ3 . TRP A 1 294 ? 0.52168   16.54066  -15.73077 1.000 40.33298  ? 294 TRP A CZ3 1 
ATOM   2218 C CH2 . TRP A 1 294 ? 0.10375   15.21111  -15.55932 1.000 47.97332  ? 294 TRP A CH2 1 
ATOM   2219 N N   . GLY A 1 295 ? 6.85520   19.52796  -12.90536 1.000 49.49601  ? 295 GLY A N   1 
ATOM   2220 C CA  . GLY A 1 295 ? 7.76363   20.62860  -13.12270 1.000 58.22598  ? 295 GLY A CA  1 
ATOM   2221 C C   . GLY A 1 295 ? 7.20509   21.71374  -14.02178 1.000 62.72775  ? 295 GLY A C   1 
ATOM   2222 O O   . GLY A 1 295 ? 7.53313   22.89251  -13.84019 1.000 57.84264  ? 295 GLY A O   1 
ATOM   2223 N N   . ARG A 1 296 ? 6.36870   21.33850  -14.98414 1.000 62.78232  ? 296 ARG A N   1 
ATOM   2224 C CA  . ARG A 1 296 ? 5.70237   22.27252  -15.87589 1.000 56.36465  ? 296 ARG A CA  1 
ATOM   2225 C C   . ARG A 1 296 ? 4.22412   21.92533  -15.91765 1.000 61.36126  ? 296 ARG A C   1 
ATOM   2226 O O   . ARG A 1 296 ? 3.85445   20.75156  -15.81286 1.000 59.86746  ? 296 ARG A O   1 
ATOM   2227 C CB  . ARG A 1 296 ? 6.29873   22.21713  -17.29022 1.000 62.71428  ? 296 ARG A CB  1 
ATOM   2228 C CG  . ARG A 1 296 ? 6.17349   20.85416  -17.96194 1.000 71.92998  ? 296 ARG A CG  1 
ATOM   2229 C CD  . ARG A 1 296 ? 6.80250   20.83815  -19.35084 1.000 81.95719  ? 296 ARG A CD  1 
ATOM   2230 N NE  . ARG A 1 296 ? 6.39162   21.98605  -20.15644 1.000 90.11325  ? 296 ARG A NE  1 
ATOM   2231 C CZ  . ARG A 1 296 ? 6.64685   22.12352  -21.45506 1.000 85.48025  ? 296 ARG A CZ  1 
ATOM   2232 N NH1 . ARG A 1 296 ? 7.30856   21.17829  -22.10930 1.000 79.55798  ? 296 ARG A NH1 1 
ATOM   2233 N NH2 . ARG A 1 296 ? 6.23523   23.20649  -22.10302 1.000 84.79319  ? 296 ARG A NH2 1 
ATOM   2234 N N   . LYS A 1 297 ? 3.37860   22.94864  -16.04783 1.000 55.19565  ? 297 LYS A N   1 
ATOM   2235 C CA  . LYS A 1 297 ? 1.95417   22.69566  -16.22877 1.000 63.44333  ? 297 LYS A CA  1 
ATOM   2236 C C   . LYS A 1 297 ? 1.69183   22.02889  -17.57280 1.000 73.30303  ? 297 LYS A C   1 
ATOM   2237 O O   . LYS A 1 297 ? 0.96699   21.03022  -17.65069 1.000 63.66592  ? 297 LYS A O   1 
ATOM   2238 C CB  . LYS A 1 297 ? 1.15966   23.99611  -16.10215 1.000 62.01883  ? 297 LYS A CB  1 
ATOM   2239 C CG  . LYS A 1 297 ? -0.28011  23.88043  -16.58174 1.000 63.07279  ? 297 LYS A CG  1 
ATOM   2240 C CD  . LYS A 1 297 ? -1.26379  24.46691  -15.58032 1.000 70.15287  ? 297 LYS A CD  1 
ATOM   2241 C CE  . LYS A 1 297 ? -1.16170  25.98146  -15.50301 1.000 72.97208  ? 297 LYS A CE  1 
ATOM   2242 N NZ  . LYS A 1 297 ? -2.04188  26.53583  -14.42941 1.000 71.97362  ? 297 LYS A NZ  1 
ATOM   2243 N N   . GLY A 1 298 ? 2.29266   22.55327  -18.63612 1.000 80.31315  ? 298 GLY A N   1 
ATOM   2244 C CA  . GLY A 1 298 ? 2.07742   21.98961  -19.95855 1.000 81.75478  ? 298 GLY A CA  1 
ATOM   2245 C C   . GLY A 1 298 ? 0.63096   22.19591  -20.36969 1.000 81.93883  ? 298 GLY A C   1 
ATOM   2246 O O   . GLY A 1 298 ? 0.14074   23.33023  -20.45911 1.000 77.94611  ? 298 GLY A O   1 
ATOM   2247 N N   . ARG A 1 299 ? -0.06600  21.09508  -20.63260 1.000 79.15221  ? 299 ARG A N   1 
ATOM   2248 C CA  . ARG A 1 299 ? -1.50244  21.14074  -20.85681 1.000 82.67533  ? 299 ARG A CA  1 
ATOM   2249 C C   . ARG A 1 299 ? -2.22886  21.11077  -19.51071 1.000 85.28347  ? 299 ARG A C   1 
ATOM   2250 O O   . ARG A 1 299 ? -1.62011  20.97438  -18.44654 1.000 88.31252  ? 299 ARG A O   1 
ATOM   2251 C CB  . ARG A 1 299 ? -1.95520  19.97919  -21.74287 1.000 78.41656  ? 299 ARG A CB  1 
ATOM   2252 C CG  . ARG A 1 299 ? -3.30303  20.20730  -22.41947 1.000 78.96436  ? 299 ARG A CG  1 
ATOM   2253 C CD  . ARG A 1 299 ? -4.13322  18.92859  -22.54596 1.000 83.55155  ? 299 ARG A CD  1 
ATOM   2254 N NE  . ARG A 1 299 ? -4.84277  18.57905  -21.31693 1.000 89.55034  ? 299 ARG A NE  1 
ATOM   2255 C CZ  . ARG A 1 299 ? -5.91784  17.79622  -21.27559 1.000 92.49137  ? 299 ARG A CZ  1 
ATOM   2256 N NH1 . ARG A 1 299 ? -6.41278  17.29080  -22.39774 1.000 92.15948  ? 299 ARG A NH1 1 
ATOM   2257 N NH2 . ARG A 1 299 ? -6.50485  17.52459  -20.11604 1.000 92.13599  ? 299 ARG A NH2 1 
ATOM   2258 N N   . GLY A 1 300 ? -3.55007  21.23723  -19.55584 1.000 84.46578  ? 300 GLY A N   1 
ATOM   2259 C CA  . GLY A 1 300 ? -4.35917  21.04085  -18.37175 1.000 81.54246  ? 300 GLY A CA  1 
ATOM   2260 C C   . GLY A 1 300 ? -4.57263  19.57632  -18.04364 1.000 77.00385  ? 300 GLY A C   1 
ATOM   2261 O O   . GLY A 1 300 ? -5.70343  19.15352  -17.78406 1.000 82.07252  ? 300 GLY A O   1 
ATOM   2262 N N   . LYS A 1 301 ? -3.50096  18.78547  -18.07421 1.000 69.23106  ? 301 LYS A N   1 
ATOM   2263 C CA  . LYS A 1 301 ? -3.55107  17.40316  -17.62021 1.000 64.63462  ? 301 LYS A CA  1 
ATOM   2264 C C   . LYS A 1 301 ? -3.24740  17.34989  -16.13010 1.000 57.00047  ? 301 LYS A C   1 
ATOM   2265 O O   . LYS A 1 301 ? -2.37370  18.06855  -15.63575 1.000 54.49653  ? 301 LYS A O   1 
ATOM   2266 C CB  . LYS A 1 301 ? -2.55773  16.52796  -18.38592 1.000 62.84927  ? 301 LYS A CB  1 
ATOM   2267 C CG  . LYS A 1 301 ? -2.96571  16.20717  -19.81337 1.000 71.14844  ? 301 LYS A CG  1 
ATOM   2268 C CD  . LYS A 1 301 ? -2.00881  15.19609  -20.42682 1.000 72.66155  ? 301 LYS A CD  1 
ATOM   2269 C CE  . LYS A 1 301 ? -2.29035  14.97006  -21.89957 1.000 72.29197  ? 301 LYS A CE  1 
ATOM   2270 N NZ  . LYS A 1 301 ? -1.29962  14.03062  -22.49624 1.000 70.43649  ? 301 LYS A NZ  1 
ATOM   2271 N N   . SER A 1 302 ? -3.98042  16.50603  -15.41914 1.000 46.06612  ? 302 SER A N   1 
ATOM   2272 C CA  . SER A 1 302 ? -3.81004  16.37233  -13.97699 1.000 45.73417  ? 302 SER A CA  1 
ATOM   2273 C C   . SER A 1 302 ? -2.97037  15.14786  -13.65773 1.000 39.68328  ? 302 SER A C   1 
ATOM   2274 O O   . SER A 1 302 ? -3.26133  14.05922  -14.16833 1.000 38.73593  ? 302 SER A O   1 
ATOM   2275 C CB  . SER A 1 302 ? -5.16364  16.25884  -13.27922 1.000 46.88155  ? 302 SER A CB  1 
ATOM   2276 O OG  . SER A 1 302 ? -4.99840  15.88634  -11.91878 1.000 42.59529  ? 302 SER A OG  1 
ATOM   2277 N N   . PRO A 1 303 ? -1.92317  15.28314  -12.83983 1.000 39.17697  ? 303 PRO A N   1 
ATOM   2278 C CA  . PRO A 1 303 ? -1.20753  14.08920  -12.36174 1.000 36.26417  ? 303 PRO A CA  1 
ATOM   2279 C C   . PRO A 1 303 ? -2.07069  13.16875  -11.52278 1.000 35.40720  ? 303 PRO A C   1 
ATOM   2280 O O   . PRO A 1 303 ? -1.72509  11.99306  -11.36946 1.000 37.61884  ? 303 PRO A O   1 
ATOM   2281 C CB  . PRO A 1 303 ? -0.05212  14.67422  -11.53604 1.000 37.58931  ? 303 PRO A CB  1 
ATOM   2282 C CG  . PRO A 1 303 ? 0.12277   16.06734  -12.05443 1.000 41.40582  ? 303 PRO A CG  1 
ATOM   2283 C CD  . PRO A 1 303 ? -1.25691  16.53179  -12.43556 1.000 36.15581  ? 303 PRO A CD  1 
ATOM   2284 N N   . LEU A 1 304 ? -3.18298  13.65959  -10.97418 1.000 35.49991  ? 304 LEU A N   1 
ATOM   2285 C CA  . LEU A 1 304 ? -4.05228  12.81260  -10.16478 1.000 32.51859  ? 304 LEU A CA  1 
ATOM   2286 C C   . LEU A 1 304 ? -5.00920  11.97176  -11.00285 1.000 32.98430  ? 304 LEU A C   1 
ATOM   2287 O O   . LEU A 1 304 ? -5.47537  10.92970  -10.52423 1.000 38.58958  ? 304 LEU A O   1 
ATOM   2288 C CB  . LEU A 1 304 ? -4.85073  13.67060  -9.17809  1.000 29.03508  ? 304 LEU A CB  1 
ATOM   2289 C CG  . LEU A 1 304 ? -4.04451  14.55070  -8.21799  1.000 36.23362  ? 304 LEU A CG  1 
ATOM   2290 C CD1 . LEU A 1 304 ? -4.95519  15.21024  -7.20764  1.000 34.20779  ? 304 LEU A CD1 1 
ATOM   2291 C CD2 . LEU A 1 304 ? -2.93884  13.76060  -7.52442  1.000 34.04060  ? 304 LEU A CD2 1 
ATOM   2292 N N   . TYR A 1 305 ? -5.32065  12.39478  -12.22881 1.000 36.92697  ? 305 TYR A N   1 
ATOM   2293 C CA  . TYR A 1 305 ? -6.26049  11.66623  -13.08871 1.000 42.38381  ? 305 TYR A CA  1 
ATOM   2294 C C   . TYR A 1 305 ? -5.66970  11.59563  -14.49271 1.000 45.17904  ? 305 TYR A C   1 
ATOM   2295 O O   . TYR A 1 305 ? -5.69039  12.58760  -15.22803 1.000 52.27118  ? 305 TYR A O   1 
ATOM   2296 C CB  . TYR A 1 305 ? -7.63293  12.32888  -13.11917 1.000 35.42550  ? 305 TYR A CB  1 
ATOM   2297 C CG  . TYR A 1 305 ? -8.32905  12.42690  -11.78356 1.000 33.48705  ? 305 TYR A CG  1 
ATOM   2298 C CD1 . TYR A 1 305 ? -9.09637  11.37448  -11.29666 1.000 36.23131  ? 305 TYR A CD1 1 
ATOM   2299 C CD2 . TYR A 1 305 ? -8.23925  13.58282  -11.01973 1.000 35.98828  ? 305 TYR A CD2 1 
ATOM   2300 C CE1 . TYR A 1 305 ? -9.74039  11.46673  -10.07686 1.000 34.62486  ? 305 TYR A CE1 1 
ATOM   2301 C CE2 . TYR A 1 305 ? -8.88119  13.68744  -9.80408  1.000 36.72457  ? 305 TYR A CE2 1 
ATOM   2302 C CZ  . TYR A 1 305 ? -9.62939  12.62941  -9.33845  1.000 34.53212  ? 305 TYR A CZ  1 
ATOM   2303 O OH  . TYR A 1 305 ? -10.26101 12.72857  -8.12132  1.000 43.13042  ? 305 TYR A OH  1 
ATOM   2304 N N   . ASP A 1 306 ? -5.16314  10.42710  -14.86836 1.000 43.54429  ? 306 ASP A N   1 
ATOM   2305 C CA  . ASP A 1 306 ? -4.58812  10.23212  -16.19421 1.000 60.21689  ? 306 ASP A CA  1 
ATOM   2306 C C   . ASP A 1 306 ? -5.68955  9.80475   -17.15693 1.000 56.67397  ? 306 ASP A C   1 
ATOM   2307 O O   . ASP A 1 306 ? -6.35525  8.78696   -16.93504 1.000 50.89007  ? 306 ASP A O   1 
ATOM   2308 C CB  . ASP A 1 306 ? -3.46942  9.19217   -16.16014 1.000 53.80818  ? 306 ASP A CB  1 
ATOM   2309 C CG  . ASP A 1 306 ? -2.72142  9.09880   -17.47826 1.000 69.41353  ? 306 ASP A CG  1 
ATOM   2310 O OD1 . ASP A 1 306 ? -2.87763  10.01210  -18.31705 1.000 63.45895  ? 306 ASP A OD1 1 
ATOM   2311 O OD2 . ASP A 1 306 ? -1.98288  8.10983   -17.67825 1.000 70.90443  ? 306 ASP A OD2 1 
ATOM   2312 N N   . PHE A 1 307 ? -5.87539  10.57692  -18.22695 1.000 61.13550  ? 307 PHE A N   1 
ATOM   2313 C CA  . PHE A 1 307 ? -6.91109  10.29363  -19.21319 1.000 68.60301  ? 307 PHE A CA  1 
ATOM   2314 C C   . PHE A 1 307 ? -6.34941  10.01239  -20.60249 1.000 74.18213  ? 307 PHE A C   1 
ATOM   2315 O O   . PHE A 1 307 ? -7.11726  9.98277   -21.57149 1.000 75.83590  ? 307 PHE A O   1 
ATOM   2316 C CB  . PHE A 1 307 ? -7.91509  11.44933  -19.27979 1.000 67.72952  ? 307 PHE A CB  1 
ATOM   2317 C CG  . PHE A 1 307 ? -8.88339  11.48448  -18.12598 1.000 66.11508  ? 307 PHE A CG  1 
ATOM   2318 C CD1 . PHE A 1 307 ? -9.85316  10.50255  -17.98866 1.000 62.89806  ? 307 PHE A CD1 1 
ATOM   2319 C CD2 . PHE A 1 307 ? -8.83405  12.50603  -17.19026 1.000 62.40820  ? 307 PHE A CD2 1 
ATOM   2320 C CE1 . PHE A 1 307 ? -10.75012 10.53264  -16.93499 1.000 60.14262  ? 307 PHE A CE1 1 
ATOM   2321 C CE2 . PHE A 1 307 ? -9.72955  12.54486  -16.13387 1.000 65.74957  ? 307 PHE A CE2 1 
ATOM   2322 C CZ  . PHE A 1 307 ? -10.68906 11.55434  -16.00598 1.000 59.67313  ? 307 PHE A CZ  1 
ATOM   2323 N N   . ASP A 1 308 ? -5.04130  9.80161   -20.72867 1.000 70.42780  ? 308 ASP A N   1 
ATOM   2324 C CA  . ASP A 1 308 ? -4.46162  9.46613   -22.02168 1.000 76.86581  ? 308 ASP A CA  1 
ATOM   2325 C C   . ASP A 1 308 ? -4.94678  8.09588   -22.48759 1.000 76.39749  ? 308 ASP A C   1 
ATOM   2326 O O   . ASP A 1 308 ? -5.29632  7.22785   -21.68291 1.000 73.61670  ? 308 ASP A O   1 
ATOM   2327 C CB  . ASP A 1 308 ? -2.93303  9.48115   -21.94896 1.000 79.56765  ? 308 ASP A CB  1 
ATOM   2328 C CG  . ASP A 1 308 ? -2.37340  10.84989  -21.59805 1.000 74.05580  ? 308 ASP A CG  1 
ATOM   2329 O OD1 . ASP A 1 308 ? -3.06180  11.86277  -21.84191 1.000 72.35955  ? 308 ASP A OD1 1 
ATOM   2330 O OD2 . ASP A 1 308 ? -1.23676  10.90983  -21.08394 1.000 75.05451  ? 308 ASP A OD2 1 
ATOM   2331 N N   . VAL A 1 309 ? -4.96539  7.90852   -23.80470 1.000 81.49504  ? 309 VAL A N   1 
ATOM   2332 C CA  . VAL A 1 309 ? -5.44792  6.66531   -24.39886 1.000 81.47216  ? 309 VAL A CA  1 
ATOM   2333 C C   . VAL A 1 309 ? -4.29612  5.69254   -24.63199 1.000 77.24718  ? 309 VAL A C   1 
ATOM   2334 O O   . VAL A 1 309 ? -4.45511  4.48082   -24.47621 1.000 77.05682  ? 309 VAL A O   1 
ATOM   2335 C CB  . VAL A 1 309 ? -6.20497  6.93506   -25.71479 1.000 77.99206  ? 309 VAL A CB  1 
HETATM 2336 O O   . HOH B 2 .   ? 0.61881   46.45949  1.04655   1.000 53.00284  ? 401 HOH A O   1 
HETATM 2337 O O   . HOH B 2 .   ? -3.97951  32.27815  2.26028   1.000 52.20429  ? 402 HOH A O   1 
HETATM 2338 O O   . HOH B 2 .   ? 2.29193   40.27189  16.32453  1.000 54.80187  ? 403 HOH A O   1 
HETATM 2339 O O   . HOH B 2 .   ? -0.07599  36.56196  0.48292   1.000 45.84540  ? 404 HOH A O   1 
HETATM 2340 O O   . HOH B 2 .   ? -3.86672  36.40654  3.04187   1.000 51.59157  ? 405 HOH A O   1 
HETATM 2341 O O   . HOH B 2 .   ? 20.48499  0.24709   -3.93982  1.000 40.18937  ? 406 HOH A O   1 
HETATM 2342 O O   . HOH B 2 .   ? 27.94480  29.65888  -6.40656  1.000 51.71753  ? 407 HOH A O   1 
HETATM 2343 O O   . HOH B 2 .   ? 5.06932   38.94935  -4.16844  1.000 45.92209  ? 408 HOH A O   1 
HETATM 2344 O O   . HOH B 2 .   ? 10.71801  7.14674   7.04065   1.000 46.97349  ? 409 HOH A O   1 
HETATM 2345 O O   . HOH B 2 .   ? 0.73867   10.71324  -11.69560 1.000 46.74582  ? 410 HOH A O   1 
HETATM 2346 O O   . HOH B 2 .   ? 0.00100   21.89204  12.70469  1.000 55.92977  ? 411 HOH A O   1 
HETATM 2347 O O   . HOH B 2 .   ? -0.79942  5.32343   -8.80545  1.000 43.18372  ? 412 HOH A O   1 
HETATM 2348 O O   . HOH B 2 .   ? -14.92475 11.51569  -0.74191  1.000 43.80383  ? 413 HOH A O   1 
HETATM 2349 O O   . HOH B 2 .   ? -9.84608  6.70191   -2.33047  1.000 38.10414  ? 414 HOH A O   1 
HETATM 2350 O O   . HOH B 2 .   ? 7.48827   11.55061  10.39304  1.000 56.06700  ? 415 HOH A O   1 
HETATM 2351 O O   . HOH B 2 .   ? 4.25802   25.47858  -7.38173  1.000 42.51276  ? 416 HOH A O   1 
HETATM 2352 O O   . HOH B 2 .   ? 25.17624  5.84434   -9.66201  1.000 38.75719  ? 417 HOH A O   1 
HETATM 2353 O O   . HOH B 2 .   ? 16.42811  42.16425  -8.88988  1.000 40.93279  ? 418 HOH A O   1 
HETATM 2354 O O   . HOH B 2 .   ? 2.03659   2.58343   -9.77167  1.000 38.67061  ? 419 HOH A O   1 
HETATM 2355 O O   . HOH B 2 .   ? 12.01882  34.07818  -10.28941 1.000 41.87724  ? 420 HOH A O   1 
HETATM 2356 O O   . HOH B 2 .   ? 7.39724   28.38387  -11.52426 1.000 60.68870  ? 421 HOH A O   1 
HETATM 2357 O O   . HOH B 2 .   ? 7.46772   19.07512  -6.03224  1.000 33.34214  ? 422 HOH A O   1 
HETATM 2358 O O   . HOH B 2 .   ? 14.61201  31.28712  -5.04137  1.000 48.95254  ? 423 HOH A O   1 
HETATM 2359 O O   . HOH B 2 .   ? 23.35150  9.44540   -8.81986  1.000 39.83803  ? 424 HOH A O   1 
HETATM 2360 O O   . HOH B 2 .   ? -4.79260  29.71484  -3.65063  1.000 44.45321  ? 425 HOH A O   1 
HETATM 2361 O O   . HOH B 2 .   ? 16.20078  0.44073   -16.50272 1.000 52.28687  ? 426 HOH A O   1 
HETATM 2362 O O   . HOH B 2 .   ? 14.10302  40.07899  10.88644  1.000 54.06202  ? 427 HOH A O   1 
HETATM 2363 O O   . HOH B 2 .   ? 7.50458   12.55592  2.17174   1.000 33.07802  ? 428 HOH A O   1 
HETATM 2364 O O   . HOH B 2 .   ? 6.82893   17.47300  -3.92511  1.000 28.52557  ? 429 HOH A O   1 
HETATM 2365 O O   . HOH B 2 .   ? 27.93754  41.56965  -3.02590  1.000 41.04300  ? 430 HOH A O   1 
HETATM 2366 O O   . HOH B 2 .   ? 12.97044  31.98245  4.37620   1.000 45.84773  ? 431 HOH A O   1 
HETATM 2367 O O   . HOH B 2 .   ? 15.49358  3.76145   2.07107   1.000 40.91274  ? 432 HOH A O   1 
HETATM 2368 O O   . HOH B 2 .   ? 12.73391  -7.51340  -1.23681  1.000 35.78301  ? 433 HOH A O   1 
HETATM 2369 O O   . HOH B 2 .   ? 13.66284  -9.83905  -2.18991  1.000 34.94833  ? 434 HOH A O   1 
HETATM 2370 O O   . HOH B 2 .   ? -5.53890  14.69045  -16.99448 1.000 53.74269  ? 435 HOH A O   1 
HETATM 2371 O O   . HOH B 2 .   ? 19.52626  -1.14514  -0.14544  1.000 51.86667  ? 436 HOH A O   1 
HETATM 2372 O O   . HOH B 2 .   ? 4.89518   7.32887   -10.42492 1.000 34.39380  ? 437 HOH A O   1 
HETATM 2373 O O   . HOH B 2 .   ? -2.21418  32.12390  -0.05858  1.000 52.11388  ? 438 HOH A O   1 
HETATM 2374 O O   . HOH B 2 .   ? 5.79960   12.22376  5.94383   1.000 38.47958  ? 439 HOH A O   1 
HETATM 2375 O O   . HOH B 2 .   ? 18.11910  -7.94798  -13.35919 1.000 50.59703  ? 440 HOH A O   1 
HETATM 2376 O O   . HOH B 2 .   ? -5.67024  8.11610   10.74170  1.000 44.86230  ? 441 HOH A O   1 
HETATM 2377 O O   . HOH B 2 .   ? 15.95686  -8.62484  -13.16955 1.000 41.59049  ? 442 HOH A O   1 
HETATM 2378 O O   . HOH B 2 .   ? 25.75253  0.87768   -4.53897  1.000 51.31130  ? 443 HOH A O   1 
HETATM 2379 O O   . HOH B 2 .   ? 21.95850  9.45266   -16.35295 1.000 54.09854  ? 444 HOH A O   1 
HETATM 2380 O O   . HOH B 2 .   ? 26.50127  2.99746   -7.63566  1.000 39.44848  ? 445 HOH A O   1 
HETATM 2381 O O   . HOH B 2 .   ? -1.86833  23.04630  11.93265  1.000 51.47512  ? 446 HOH A O   1 
HETATM 2382 O O   . HOH B 2 .   ? -9.79809  15.03585  -6.63857  1.000 42.98824  ? 447 HOH A O   1 
HETATM 2383 O O   . HOH B 2 .   ? 5.57694   7.82115   7.99890   1.000 38.23782  ? 448 HOH A O   1 
HETATM 2384 O O   . HOH B 2 .   ? 6.060     0.163     7.051     1.000 44.06396  ? 449 HOH A O   1 
HETATM 2385 O O   . HOH B 2 .   ? 9.646     -6.069    -10.294   1.000 34.81506  ? 450 HOH A O   1 
HETATM 2386 O O   . HOH B 2 .   ? 12.01977  8.54029   -16.92361 1.000 47.00958  ? 451 HOH A O   1 
HETATM 2387 O O   . HOH B 2 .   ? -5.51346  2.40893   7.31312   1.000 43.43653  ? 452 HOH A O   1 
HETATM 2388 O O   . HOH B 2 .   ? -2.65462  9.33757   -11.35540 1.000 40.27390  ? 453 HOH A O   1 
HETATM 2389 O O   . HOH B 2 .   ? 16.53342  1.13754   2.19432   1.000 46.14513  ? 454 HOH A O   1 
HETATM 2390 O O   . HOH B 2 .   ? 16.97739  40.47158  2.31741   1.000 41.82736  ? 455 HOH A O   1 
HETATM 2391 O O   . HOH B 2 .   ? 23.55350  1.80353   -13.29521 1.000 42.68489  ? 456 HOH A O   1 
HETATM 2392 O O   . HOH B 2 .   ? 6.55991   37.93895  -6.45569  1.000 39.39519  ? 457 HOH A O   1 
HETATM 2393 O O   . HOH B 2 .   ? 10.41905  43.32854  -8.93814  1.000 40.67331  ? 458 HOH A O   1 
HETATM 2394 O O   . HOH B 2 .   ? -9.41895  9.07352   -3.48594  1.000 28.99993  ? 459 HOH A O   1 
HETATM 2395 O O   . HOH B 2 .   ? -1.08577  7.45791   -10.39021 1.000 46.86630  ? 460 HOH A O   1 
HETATM 2396 O O   . HOH B 2 .   ? 0.60138   25.79749  -12.88312 1.000 53.74933  ? 461 HOH A O   1 
HETATM 2397 O O   . HOH B 2 .   ? -4.76182  31.66762  11.70902  1.000 54.95407  ? 462 HOH A O   1 
HETATM 2398 O O   . HOH B 2 .   ? 12.80853  23.97882  0.68300   1.000 46.14848  ? 463 HOH A O   1 
HETATM 2399 O O   . HOH B 2 .   ? 12.20546  39.11022  5.41272   1.000 44.29642  ? 464 HOH A O   1 
HETATM 2400 O O   . HOH B 2 .   ? -10.16556 8.06574   -6.28098  1.000 42.81880  ? 465 HOH A O   1 
HETATM 2401 O O   . HOH B 2 .   ? 2.313     -2.834    -8.575    1.000 31.79881  ? 466 HOH A O   1 
HETATM 2402 O O   . HOH B 2 .   ? 13.92334  35.36825  25.07489  1.000 60.07039  ? 467 HOH A O   1 
HETATM 2403 O O   . HOH B 2 .   ? 9.72736   6.88834   -15.80760 1.000 35.04807  ? 468 HOH A O   1 
HETATM 2404 O O   . HOH B 2 .   ? 13.44541  32.21155  -9.06137  1.000 45.76838  ? 469 HOH A O   1 
HETATM 2405 O O   . HOH B 2 .   ? 25.23594  5.88678   -0.89213  1.000 44.88298  ? 470 HOH A O   1 
HETATM 2406 O O   . HOH B 2 .   ? -11.79913 10.60496  -6.82950  1.000 45.74169  ? 471 HOH A O   1 
HETATM 2407 O O   . HOH B 2 .   ? 19.39105  -5.46049  0.82532   1.000 37.51048  ? 472 HOH A O   1 
HETATM 2408 O O   . HOH B 2 .   ? 23.90601  40.57505  -2.02536  1.000 48.71504  ? 473 HOH A O   1 
HETATM 2409 O O   . HOH B 2 .   ? 12.86733  19.88999  -5.69082  1.000 52.24253  ? 474 HOH A O   1 
HETATM 2410 O O   . HOH B 2 .   ? 18.08372  43.08951  -6.68469  1.000 47.67359  ? 475 HOH A O   1 
HETATM 2411 O O   . HOH B 2 .   ? 8.72370   28.55324  10.44339  1.000 49.04521  ? 476 HOH A O   1 
HETATM 2412 O O   . HOH B 2 .   ? 11.71918  26.71699  1.61523   1.000 40.40631  ? 477 HOH A O   1 
HETATM 2413 O O   . HOH B 2 .   ? -6.28810  33.50190  5.37285   1.000 44.51620  ? 478 HOH A O   1 
HETATM 2414 O O   . HOH B 2 .   ? 5.97371   36.29110  -11.49519 1.000 48.66522  ? 479 HOH A O   1 
HETATM 2415 O O   . HOH B 2 .   ? 9.55068   16.96886  -3.56662  1.000 33.66478  ? 480 HOH A O   1 
HETATM 2416 O O   . HOH B 2 .   ? 15.38441  13.72273  -4.62644  1.000 44.05893  ? 481 HOH A O   1 
HETATM 2417 O O   . HOH B 2 .   ? 3.86749   37.84157  -2.03012  1.000 45.06982  ? 482 HOH A O   1 
HETATM 2418 O O   . HOH B 2 .   ? -8.40965  31.20272  12.41871  1.000 61.76370  ? 483 HOH A O   1 
HETATM 2419 O O   . HOH B 2 .   ? -5.25324  18.24421  -10.04537 1.000 45.67876  ? 484 HOH A O   1 
HETATM 2420 O O   . HOH B 2 .   ? 15.80886  14.54819  1.60634   1.000 59.41286  ? 485 HOH A O   1 
HETATM 2421 O O   . HOH B 2 .   ? 14.18172  -1.73881  -16.45923 1.000 46.23960  ? 486 HOH A O   1 
HETATM 2422 O O   . HOH B 2 .   ? 19.75848  40.01602  1.66028   1.000 48.78752  ? 487 HOH A O   1 
HETATM 2423 O O   . HOH B 2 .   ? -1.08122  31.85124  -5.16064  1.000 42.11114  ? 488 HOH A O   1 
HETATM 2424 O O   . HOH B 2 .   ? 20.39499  -8.88681  -1.60139  1.000 50.29684  ? 489 HOH A O   1 
HETATM 2425 O O   . HOH B 2 .   ? 20.12824  -10.01182 -3.54941  1.000 57.75063  ? 490 HOH A O   1 
HETATM 2426 O O   . HOH B 2 .   ? 0.61849   25.88942  17.05471  1.000 59.03742  ? 491 HOH A O   1 
HETATM 2427 O O   . HOH B 2 .   ? -2.57525  33.56380  5.85524   1.000 47.72790  ? 492 HOH A O   1 
HETATM 2428 O O   . HOH B 2 .   ? 22.808    -0.385    -1.295    1.000 54.63561  ? 493 HOH A O   1 
HETATM 2429 O O   . HOH B 2 .   ? 1.585     42.149    0.910     1.000 50.76629  ? 494 HOH A O   1 
HETATM 2430 O O   . HOH B 2 .   ? 22.08330  -0.67073  -16.51619 1.000 45.36540  ? 495 HOH A O   1 
HETATM 2431 O O   . HOH B 2 .   ? 12.04218  16.60077  -6.02696  1.000 62.50640  ? 496 HOH A O   1 
HETATM 2432 O O   . HOH B 2 .   ? -11.53300 11.01399  -3.64031  1.000 32.49678  ? 497 HOH A O   1 
HETATM 2433 O O   . HOH B 2 .   ? 25.37793  3.48986   -0.20096  1.000 52.81538  ? 498 HOH A O   1 
HETATM 2434 O O   . HOH B 2 .   ? -7.499    40.154    4.790     1.000 55.77105  ? 499 HOH A O   1 
HETATM 2435 O O   . HOH B 2 .   ? -9.847    41.245    10.671    1.000 46.08196  ? 500 HOH A O   1 
HETATM 2436 O O   . HOH B 2 .   ? 7.96855   8.05785   7.74278   1.000 47.46044  ? 501 HOH A O   1 
HETATM 2437 O O   . HOH B 2 .   ? 14.54691  21.46837  -17.65370 1.000 71.22727  ? 502 HOH A O   1 
HETATM 2438 O O   . HOH B 2 .   ? -12.045   40.230    10.161    1.000 47.47804  ? 503 HOH A O   1 
HETATM 2439 O O   . HOH B 2 .   ? -2.57618  37.47011  -0.97827  1.000 58.27889  ? 504 HOH A O   1 
HETATM 2440 O O   . HOH B 2 .   ? 6.17525   39.52806  -8.80948  1.000 44.19862  ? 505 HOH A O   1 
HETATM 2441 O O   . HOH B 2 .   ? -4.22233  33.90206  -3.12505  1.000 48.80486  ? 506 HOH A O   1 
HETATM 2442 O O   . HOH B 2 .   ? 22.82623  -1.69973  -9.88580  1.000 45.38341  ? 507 HOH A O   1 
HETATM 2443 O O   . HOH B 2 .   ? 1.31567   38.99437  -1.30155  1.000 54.50767  ? 508 HOH A O   1 
HETATM 2444 O O   . HOH B 2 .   ? 11.77477  13.82353  -14.63001 1.000 59.19274  ? 509 HOH A O   1 
HETATM 2445 O O   . HOH B 2 .   ? -2.75809  31.58587  -2.99600  1.000 46.16679  ? 510 HOH A O   1 
HETATM 2446 O O   . HOH B 2 .   ? 4.67334   10.29392  7.48856   1.000 41.82390  ? 511 HOH A O   1 
HETATM 2447 O O   . HOH B 2 .   ? -2.05108  26.75947  13.66642  1.000 58.64542  ? 512 HOH A O   1 
HETATM 2448 O O   . HOH B 2 .   ? 15.88053  12.71209  -14.27822 1.000 42.71436  ? 513 HOH A O   1 
HETATM 2449 O O   . HOH B 2 .   ? 7.89569   7.50843   12.18437  1.000 69.48197  ? 514 HOH A O   1 
# 
