data_8X3M
# 
_entry.id   8X3M 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8X3M         pdb_00008x3m 10.2210/pdb8x3m/pdb 
WWPDB D_1300042550 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2024-11-20 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.journal_volume'          
7  2 'Structure model' '_citation.page_first'              
8  2 'Structure model' '_citation.page_last'               
9  2 'Structure model' '_citation.pdbx_database_id_DOI'    
10 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 2 'Structure model' '_citation.title'                   
12 2 'Structure model' '_citation.year'                    
13 2 'Structure model' '_citation_author.identifier_ORCID' 
14 2 'Structure model' '_citation_author.name'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8X3M 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-14 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          7x4u 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              kinotk@omu.ac.jp 
_pdbx_contact_author.name_first         Takayoshi 
_pdbx_contact_author.name_last          Kinoshita 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2850-5409 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hasegawa, S.'  1 0009-0004-4952-0434 
'Kinoshita, T.' 2 0000-0003-2850-5409 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochem.Biophys.Res.Commun. 
_citation.journal_id_ASTM           BBRCA9 
_citation.journal_id_CSD            0146 
_citation.journal_id_ISSN           1090-2104 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            704 
_citation.language                  ? 
_citation.page_first                149707 
_citation.page_last                 149707 
_citation.title                     
'Distinct binding modes of a benzothiazole derivative confer structural bases for increasing ERK2 or p38 alpha MAPK selectivity.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.bbrc.2024.149707 
_citation.pdbx_database_id_PubMed   38428305 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hasegawa, S.'  1 ? 
primary 'Yoshida, M.'   2 ? 
primary 'Nagao, H.'     3 ? 
primary 'Sugiyama, H.'  4 ? 
primary 'Sawa, M.'      5 ? 
primary 'Kinoshita, T.' 6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Mitogen-activated protein kinase 14'                                                                  41754.648 
1   2.7.11.24 ? ? ? 
2 non-polymer syn '~{N}-(5,6-dimethoxy-1,3-benzothiazol-2-yl)-2-[(4-fluoranylphenoxy)methyl]-1,3-thiazole-4-carboxamide' 445.487   
1   ?         ? ? ? 
3 water       nat water                                                                                                  18.015    
478 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;MAP kinase 14,MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSAID-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPLGSMSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL
KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN
LAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI
LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD
DEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPLGSMSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL
KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN
LAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI
LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD
DEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '~{N}-(5,6-dimethoxy-1,3-benzothiazol-2-yl)-2-[(4-fluoranylphenoxy)methyl]-1,3-thiazole-4-carboxamide' B8Z 
3 water                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   LEU n 
1 4   GLY n 
1 5   SER n 
1 6   MET n 
1 7   SER n 
1 8   GLN n 
1 9   GLU n 
1 10  ARG n 
1 11  PRO n 
1 12  THR n 
1 13  PHE n 
1 14  TYR n 
1 15  ARG n 
1 16  GLN n 
1 17  GLU n 
1 18  LEU n 
1 19  ASN n 
1 20  LYS n 
1 21  THR n 
1 22  ILE n 
1 23  TRP n 
1 24  GLU n 
1 25  VAL n 
1 26  PRO n 
1 27  GLU n 
1 28  ARG n 
1 29  TYR n 
1 30  GLN n 
1 31  ASN n 
1 32  LEU n 
1 33  SER n 
1 34  PRO n 
1 35  VAL n 
1 36  GLY n 
1 37  SER n 
1 38  GLY n 
1 39  ALA n 
1 40  TYR n 
1 41  GLY n 
1 42  SER n 
1 43  VAL n 
1 44  CYS n 
1 45  ALA n 
1 46  ALA n 
1 47  PHE n 
1 48  ASP n 
1 49  THR n 
1 50  LYS n 
1 51  THR n 
1 52  GLY n 
1 53  LEU n 
1 54  ARG n 
1 55  VAL n 
1 56  ALA n 
1 57  VAL n 
1 58  LYS n 
1 59  LYS n 
1 60  LEU n 
1 61  SER n 
1 62  ARG n 
1 63  PRO n 
1 64  PHE n 
1 65  GLN n 
1 66  SER n 
1 67  ILE n 
1 68  ILE n 
1 69  HIS n 
1 70  ALA n 
1 71  LYS n 
1 72  ARG n 
1 73  THR n 
1 74  TYR n 
1 75  ARG n 
1 76  GLU n 
1 77  LEU n 
1 78  ARG n 
1 79  LEU n 
1 80  LEU n 
1 81  LYS n 
1 82  HIS n 
1 83  MET n 
1 84  LYS n 
1 85  HIS n 
1 86  GLU n 
1 87  ASN n 
1 88  VAL n 
1 89  ILE n 
1 90  GLY n 
1 91  LEU n 
1 92  LEU n 
1 93  ASP n 
1 94  VAL n 
1 95  PHE n 
1 96  THR n 
1 97  PRO n 
1 98  ALA n 
1 99  ARG n 
1 100 SER n 
1 101 LEU n 
1 102 GLU n 
1 103 GLU n 
1 104 PHE n 
1 105 ASN n 
1 106 ASP n 
1 107 VAL n 
1 108 TYR n 
1 109 LEU n 
1 110 VAL n 
1 111 THR n 
1 112 HIS n 
1 113 LEU n 
1 114 MET n 
1 115 GLY n 
1 116 ALA n 
1 117 ASP n 
1 118 LEU n 
1 119 ASN n 
1 120 ASN n 
1 121 ILE n 
1 122 VAL n 
1 123 LYS n 
1 124 CYS n 
1 125 GLN n 
1 126 LYS n 
1 127 LEU n 
1 128 THR n 
1 129 ASP n 
1 130 ASP n 
1 131 HIS n 
1 132 VAL n 
1 133 GLN n 
1 134 PHE n 
1 135 LEU n 
1 136 ILE n 
1 137 TYR n 
1 138 GLN n 
1 139 ILE n 
1 140 LEU n 
1 141 ARG n 
1 142 GLY n 
1 143 LEU n 
1 144 LYS n 
1 145 TYR n 
1 146 ILE n 
1 147 HIS n 
1 148 SER n 
1 149 ALA n 
1 150 ASP n 
1 151 ILE n 
1 152 ILE n 
1 153 HIS n 
1 154 ARG n 
1 155 ASP n 
1 156 LEU n 
1 157 LYS n 
1 158 PRO n 
1 159 SER n 
1 160 ASN n 
1 161 LEU n 
1 162 ALA n 
1 163 VAL n 
1 164 ASN n 
1 165 GLU n 
1 166 ASP n 
1 167 CYS n 
1 168 GLU n 
1 169 LEU n 
1 170 LYS n 
1 171 ILE n 
1 172 LEU n 
1 173 ASP n 
1 174 PHE n 
1 175 GLY n 
1 176 LEU n 
1 177 ALA n 
1 178 ARG n 
1 179 HIS n 
1 180 THR n 
1 181 ASP n 
1 182 ASP n 
1 183 GLU n 
1 184 MET n 
1 185 THR n 
1 186 GLY n 
1 187 TYR n 
1 188 VAL n 
1 189 ALA n 
1 190 THR n 
1 191 ARG n 
1 192 TRP n 
1 193 TYR n 
1 194 ARG n 
1 195 ALA n 
1 196 PRO n 
1 197 GLU n 
1 198 ILE n 
1 199 MET n 
1 200 LEU n 
1 201 ASN n 
1 202 TRP n 
1 203 MET n 
1 204 HIS n 
1 205 TYR n 
1 206 ASN n 
1 207 GLN n 
1 208 THR n 
1 209 VAL n 
1 210 ASP n 
1 211 ILE n 
1 212 TRP n 
1 213 SER n 
1 214 VAL n 
1 215 GLY n 
1 216 CYS n 
1 217 ILE n 
1 218 MET n 
1 219 ALA n 
1 220 GLU n 
1 221 LEU n 
1 222 LEU n 
1 223 THR n 
1 224 GLY n 
1 225 ARG n 
1 226 THR n 
1 227 LEU n 
1 228 PHE n 
1 229 PRO n 
1 230 GLY n 
1 231 THR n 
1 232 ASP n 
1 233 HIS n 
1 234 ILE n 
1 235 ASP n 
1 236 GLN n 
1 237 LEU n 
1 238 LYS n 
1 239 LEU n 
1 240 ILE n 
1 241 LEU n 
1 242 ARG n 
1 243 LEU n 
1 244 VAL n 
1 245 GLY n 
1 246 THR n 
1 247 PRO n 
1 248 GLY n 
1 249 ALA n 
1 250 GLU n 
1 251 LEU n 
1 252 LEU n 
1 253 LYS n 
1 254 LYS n 
1 255 ILE n 
1 256 SER n 
1 257 SER n 
1 258 GLU n 
1 259 SER n 
1 260 ALA n 
1 261 ARG n 
1 262 ASN n 
1 263 TYR n 
1 264 ILE n 
1 265 GLN n 
1 266 SER n 
1 267 LEU n 
1 268 THR n 
1 269 GLN n 
1 270 MET n 
1 271 PRO n 
1 272 LYS n 
1 273 MET n 
1 274 ASN n 
1 275 PHE n 
1 276 ALA n 
1 277 ASN n 
1 278 VAL n 
1 279 PHE n 
1 280 ILE n 
1 281 GLY n 
1 282 ALA n 
1 283 ASN n 
1 284 PRO n 
1 285 LEU n 
1 286 ALA n 
1 287 VAL n 
1 288 ASP n 
1 289 LEU n 
1 290 LEU n 
1 291 GLU n 
1 292 LYS n 
1 293 MET n 
1 294 LEU n 
1 295 VAL n 
1 296 LEU n 
1 297 ASP n 
1 298 SER n 
1 299 ASP n 
1 300 LYS n 
1 301 ARG n 
1 302 ILE n 
1 303 THR n 
1 304 ALA n 
1 305 ALA n 
1 306 GLN n 
1 307 ALA n 
1 308 LEU n 
1 309 ALA n 
1 310 HIS n 
1 311 ALA n 
1 312 TYR n 
1 313 PHE n 
1 314 ALA n 
1 315 GLN n 
1 316 TYR n 
1 317 HIS n 
1 318 ASP n 
1 319 PRO n 
1 320 ASP n 
1 321 ASP n 
1 322 GLU n 
1 323 PRO n 
1 324 VAL n 
1 325 ALA n 
1 326 ASP n 
1 327 PRO n 
1 328 TYR n 
1 329 ASP n 
1 330 GLN n 
1 331 SER n 
1 332 PHE n 
1 333 GLU n 
1 334 SER n 
1 335 ARG n 
1 336 ASP n 
1 337 LEU n 
1 338 LEU n 
1 339 ILE n 
1 340 ASP n 
1 341 GLU n 
1 342 TRP n 
1 343 LYS n 
1 344 SER n 
1 345 LEU n 
1 346 THR n 
1 347 TYR n 
1 348 ASP n 
1 349 GLU n 
1 350 VAL n 
1 351 ILE n 
1 352 SER n 
1 353 PHE n 
1 354 VAL n 
1 355 PRO n 
1 356 PRO n 
1 357 PRO n 
1 358 LEU n 
1 359 ASP n 
1 360 GLN n 
1 361 GLU n 
1 362 GLU n 
1 363 MET n 
1 364 GLU n 
1 365 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   365 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                ? 
'C3 H7 N O2'         89.093  
ARG 'L-peptide linking' y ARGININE                                                                                               ? 
'C6 H15 N4 O2 1'     175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                             ? 
'C4 H8 N2 O3'        132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                        ? 
'C4 H7 N O4'         133.103 
B8Z non-polymer         . '~{N}-(5,6-dimethoxy-1,3-benzothiazol-2-yl)-2-[(4-fluoranylphenoxy)methyl]-1,3-thiazole-4-carboxamide' ? 
'C20 H16 F N3 O4 S2' 445.487 
CYS 'L-peptide linking' y CYSTEINE                                                                                               ? 
'C3 H7 N O2 S'       121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                              ? 
'C5 H10 N2 O3'       146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                        ? 
'C5 H9 N O4'         147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                ? 
'C2 H5 N O2'         75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                              ? 
'C6 H10 N3 O2 1'     156.162 
HOH non-polymer         . WATER                                                                                                  ? 
'H2 O'               18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                             ? 
'C6 H13 N O2'        131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                ? 
'C6 H13 N O2'        131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                 ? 
'C6 H15 N2 O2 1'     147.195 
MET 'L-peptide linking' y METHIONINE                                                                                             ? 
'C5 H11 N O2 S'      149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                          ? 
'C9 H11 N O2'        165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                ? 
'C5 H9 N O2'         115.130 
SER 'L-peptide linking' y SERINE                                                                                                 ? 
'C3 H7 N O3'         105.093 
THR 'L-peptide linking' y THREONINE                                                                                              ? 
'C4 H9 N O3'         119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                             ? 
'C11 H12 N2 O2'      204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                               ? 
'C9 H11 N O3'        181.189 
VAL 'L-peptide linking' y VALINE                                                                                                 ? 
'C5 H11 N O2'        117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -4  ?   ?   ?   A . n 
A 1 2   PRO 2   -3  ?   ?   ?   A . n 
A 1 3   LEU 3   -2  ?   ?   ?   A . n 
A 1 4   GLY 4   -1  ?   ?   ?   A . n 
A 1 5   SER 5   0   ?   ?   ?   A . n 
A 1 6   MET 6   1   ?   ?   ?   A . n 
A 1 7   SER 7   2   ?   ?   ?   A . n 
A 1 8   GLN 8   3   ?   ?   ?   A . n 
A 1 9   GLU 9   4   4   GLU GLU A . n 
A 1 10  ARG 10  5   5   ARG ARG A . n 
A 1 11  PRO 11  6   6   PRO PRO A . n 
A 1 12  THR 12  7   7   THR THR A . n 
A 1 13  PHE 13  8   8   PHE PHE A . n 
A 1 14  TYR 14  9   9   TYR TYR A . n 
A 1 15  ARG 15  10  10  ARG ARG A . n 
A 1 16  GLN 16  11  11  GLN GLN A . n 
A 1 17  GLU 17  12  12  GLU GLU A . n 
A 1 18  LEU 18  13  13  LEU LEU A . n 
A 1 19  ASN 19  14  14  ASN ASN A . n 
A 1 20  LYS 20  15  15  LYS LYS A . n 
A 1 21  THR 21  16  16  THR THR A . n 
A 1 22  ILE 22  17  17  ILE ILE A . n 
A 1 23  TRP 23  18  18  TRP TRP A . n 
A 1 24  GLU 24  19  19  GLU GLU A . n 
A 1 25  VAL 25  20  20  VAL VAL A . n 
A 1 26  PRO 26  21  21  PRO PRO A . n 
A 1 27  GLU 27  22  22  GLU GLU A . n 
A 1 28  ARG 28  23  23  ARG ARG A . n 
A 1 29  TYR 29  24  24  TYR TYR A . n 
A 1 30  GLN 30  25  25  GLN GLN A . n 
A 1 31  ASN 31  26  26  ASN ASN A . n 
A 1 32  LEU 32  27  27  LEU LEU A . n 
A 1 33  SER 33  28  28  SER SER A . n 
A 1 34  PRO 34  29  29  PRO PRO A . n 
A 1 35  VAL 35  30  30  VAL VAL A . n 
A 1 36  GLY 36  31  31  GLY GLY A . n 
A 1 37  SER 37  32  32  SER SER A . n 
A 1 38  GLY 38  33  33  GLY GLY A . n 
A 1 39  ALA 39  34  34  ALA ALA A . n 
A 1 40  TYR 40  35  35  TYR TYR A . n 
A 1 41  GLY 41  36  36  GLY GLY A . n 
A 1 42  SER 42  37  37  SER SER A . n 
A 1 43  VAL 43  38  38  VAL VAL A . n 
A 1 44  CYS 44  39  39  CYS CYS A . n 
A 1 45  ALA 45  40  40  ALA ALA A . n 
A 1 46  ALA 46  41  41  ALA ALA A . n 
A 1 47  PHE 47  42  42  PHE PHE A . n 
A 1 48  ASP 48  43  43  ASP ASP A . n 
A 1 49  THR 49  44  44  THR THR A . n 
A 1 50  LYS 50  45  45  LYS LYS A . n 
A 1 51  THR 51  46  46  THR THR A . n 
A 1 52  GLY 52  47  47  GLY GLY A . n 
A 1 53  LEU 53  48  48  LEU LEU A . n 
A 1 54  ARG 54  49  49  ARG ARG A . n 
A 1 55  VAL 55  50  50  VAL VAL A . n 
A 1 56  ALA 56  51  51  ALA ALA A . n 
A 1 57  VAL 57  52  52  VAL VAL A . n 
A 1 58  LYS 58  53  53  LYS LYS A . n 
A 1 59  LYS 59  54  54  LYS LYS A . n 
A 1 60  LEU 60  55  55  LEU LEU A . n 
A 1 61  SER 61  56  56  SER SER A . n 
A 1 62  ARG 62  57  57  ARG ARG A . n 
A 1 63  PRO 63  58  58  PRO PRO A . n 
A 1 64  PHE 64  59  59  PHE PHE A . n 
A 1 65  GLN 65  60  60  GLN GLN A . n 
A 1 66  SER 66  61  61  SER SER A . n 
A 1 67  ILE 67  62  62  ILE ILE A . n 
A 1 68  ILE 68  63  63  ILE ILE A . n 
A 1 69  HIS 69  64  64  HIS HIS A . n 
A 1 70  ALA 70  65  65  ALA ALA A . n 
A 1 71  LYS 71  66  66  LYS LYS A . n 
A 1 72  ARG 72  67  67  ARG ARG A . n 
A 1 73  THR 73  68  68  THR THR A . n 
A 1 74  TYR 74  69  69  TYR TYR A . n 
A 1 75  ARG 75  70  70  ARG ARG A . n 
A 1 76  GLU 76  71  71  GLU GLU A . n 
A 1 77  LEU 77  72  72  LEU LEU A . n 
A 1 78  ARG 78  73  73  ARG ARG A . n 
A 1 79  LEU 79  74  74  LEU LEU A . n 
A 1 80  LEU 80  75  75  LEU LEU A . n 
A 1 81  LYS 81  76  76  LYS LYS A . n 
A 1 82  HIS 82  77  77  HIS HIS A . n 
A 1 83  MET 83  78  78  MET MET A . n 
A 1 84  LYS 84  79  79  LYS LYS A . n 
A 1 85  HIS 85  80  80  HIS HIS A . n 
A 1 86  GLU 86  81  81  GLU GLU A . n 
A 1 87  ASN 87  82  82  ASN ASN A . n 
A 1 88  VAL 88  83  83  VAL VAL A . n 
A 1 89  ILE 89  84  84  ILE ILE A . n 
A 1 90  GLY 90  85  85  GLY GLY A . n 
A 1 91  LEU 91  86  86  LEU LEU A . n 
A 1 92  LEU 92  87  87  LEU LEU A . n 
A 1 93  ASP 93  88  88  ASP ASP A . n 
A 1 94  VAL 94  89  89  VAL VAL A . n 
A 1 95  PHE 95  90  90  PHE PHE A . n 
A 1 96  THR 96  91  91  THR THR A . n 
A 1 97  PRO 97  92  92  PRO PRO A . n 
A 1 98  ALA 98  93  93  ALA ALA A . n 
A 1 99  ARG 99  94  94  ARG ARG A . n 
A 1 100 SER 100 95  95  SER SER A . n 
A 1 101 LEU 101 96  96  LEU LEU A . n 
A 1 102 GLU 102 97  97  GLU GLU A . n 
A 1 103 GLU 103 98  98  GLU GLU A . n 
A 1 104 PHE 104 99  99  PHE PHE A . n 
A 1 105 ASN 105 100 100 ASN ASN A . n 
A 1 106 ASP 106 101 101 ASP ASP A . n 
A 1 107 VAL 107 102 102 VAL VAL A . n 
A 1 108 TYR 108 103 103 TYR TYR A . n 
A 1 109 LEU 109 104 104 LEU LEU A . n 
A 1 110 VAL 110 105 105 VAL VAL A . n 
A 1 111 THR 111 106 106 THR THR A . n 
A 1 112 HIS 112 107 107 HIS HIS A . n 
A 1 113 LEU 113 108 108 LEU LEU A . n 
A 1 114 MET 114 109 109 MET MET A . n 
A 1 115 GLY 115 110 110 GLY GLY A . n 
A 1 116 ALA 116 111 111 ALA ALA A . n 
A 1 117 ASP 117 112 112 ASP ASP A . n 
A 1 118 LEU 118 113 113 LEU LEU A . n 
A 1 119 ASN 119 114 114 ASN ASN A . n 
A 1 120 ASN 120 115 115 ASN ASN A . n 
A 1 121 ILE 121 116 116 ILE ILE A . n 
A 1 122 VAL 122 117 117 VAL VAL A . n 
A 1 123 LYS 123 118 118 LYS LYS A . n 
A 1 124 CYS 124 119 119 CYS CYS A . n 
A 1 125 GLN 125 120 120 GLN GLN A . n 
A 1 126 LYS 126 121 121 LYS LYS A . n 
A 1 127 LEU 127 122 122 LEU LEU A . n 
A 1 128 THR 128 123 123 THR THR A . n 
A 1 129 ASP 129 124 124 ASP ASP A . n 
A 1 130 ASP 130 125 125 ASP ASP A . n 
A 1 131 HIS 131 126 126 HIS HIS A . n 
A 1 132 VAL 132 127 127 VAL VAL A . n 
A 1 133 GLN 133 128 128 GLN GLN A . n 
A 1 134 PHE 134 129 129 PHE PHE A . n 
A 1 135 LEU 135 130 130 LEU LEU A . n 
A 1 136 ILE 136 131 131 ILE ILE A . n 
A 1 137 TYR 137 132 132 TYR TYR A . n 
A 1 138 GLN 138 133 133 GLN GLN A . n 
A 1 139 ILE 139 134 134 ILE ILE A . n 
A 1 140 LEU 140 135 135 LEU LEU A . n 
A 1 141 ARG 141 136 136 ARG ARG A . n 
A 1 142 GLY 142 137 137 GLY GLY A . n 
A 1 143 LEU 143 138 138 LEU LEU A . n 
A 1 144 LYS 144 139 139 LYS LYS A . n 
A 1 145 TYR 145 140 140 TYR TYR A . n 
A 1 146 ILE 146 141 141 ILE ILE A . n 
A 1 147 HIS 147 142 142 HIS HIS A . n 
A 1 148 SER 148 143 143 SER SER A . n 
A 1 149 ALA 149 144 144 ALA ALA A . n 
A 1 150 ASP 150 145 145 ASP ASP A . n 
A 1 151 ILE 151 146 146 ILE ILE A . n 
A 1 152 ILE 152 147 147 ILE ILE A . n 
A 1 153 HIS 153 148 148 HIS HIS A . n 
A 1 154 ARG 154 149 149 ARG ARG A . n 
A 1 155 ASP 155 150 150 ASP ASP A . n 
A 1 156 LEU 156 151 151 LEU LEU A . n 
A 1 157 LYS 157 152 152 LYS LYS A . n 
A 1 158 PRO 158 153 153 PRO PRO A . n 
A 1 159 SER 159 154 154 SER SER A . n 
A 1 160 ASN 160 155 155 ASN ASN A . n 
A 1 161 LEU 161 156 156 LEU LEU A . n 
A 1 162 ALA 162 157 157 ALA ALA A . n 
A 1 163 VAL 163 158 158 VAL VAL A . n 
A 1 164 ASN 164 159 159 ASN ASN A . n 
A 1 165 GLU 165 160 160 GLU GLU A . n 
A 1 166 ASP 166 161 161 ASP ASP A . n 
A 1 167 CYS 167 162 162 CYS CYS A . n 
A 1 168 GLU 168 163 163 GLU GLU A . n 
A 1 169 LEU 169 164 164 LEU LEU A . n 
A 1 170 LYS 170 165 165 LYS LYS A . n 
A 1 171 ILE 171 166 166 ILE ILE A . n 
A 1 172 LEU 172 167 167 LEU LEU A . n 
A 1 173 ASP 173 168 168 ASP ASP A . n 
A 1 174 PHE 174 169 169 PHE PHE A . n 
A 1 175 GLY 175 170 170 GLY GLY A . n 
A 1 176 LEU 176 171 171 LEU LEU A . n 
A 1 177 ALA 177 172 172 ALA ALA A . n 
A 1 178 ARG 178 173 173 ARG ARG A . n 
A 1 179 HIS 179 174 174 HIS HIS A . n 
A 1 180 THR 180 175 175 THR THR A . n 
A 1 181 ASP 181 176 176 ASP ASP A . n 
A 1 182 ASP 182 177 177 ASP ASP A . n 
A 1 183 GLU 183 178 178 GLU GLU A . n 
A 1 184 MET 184 179 179 MET MET A . n 
A 1 185 THR 185 180 180 THR THR A . n 
A 1 186 GLY 186 181 181 GLY GLY A . n 
A 1 187 TYR 187 182 182 TYR TYR A . n 
A 1 188 VAL 188 183 183 VAL VAL A . n 
A 1 189 ALA 189 184 184 ALA ALA A . n 
A 1 190 THR 190 185 185 THR THR A . n 
A 1 191 ARG 191 186 186 ARG ARG A . n 
A 1 192 TRP 192 187 187 TRP TRP A . n 
A 1 193 TYR 193 188 188 TYR TYR A . n 
A 1 194 ARG 194 189 189 ARG ARG A . n 
A 1 195 ALA 195 190 190 ALA ALA A . n 
A 1 196 PRO 196 191 191 PRO PRO A . n 
A 1 197 GLU 197 192 192 GLU GLU A . n 
A 1 198 ILE 198 193 193 ILE ILE A . n 
A 1 199 MET 199 194 194 MET MET A . n 
A 1 200 LEU 200 195 195 LEU LEU A . n 
A 1 201 ASN 201 196 196 ASN ASN A . n 
A 1 202 TRP 202 197 197 TRP TRP A . n 
A 1 203 MET 203 198 198 MET MET A . n 
A 1 204 HIS 204 199 199 HIS HIS A . n 
A 1 205 TYR 205 200 200 TYR TYR A . n 
A 1 206 ASN 206 201 201 ASN ASN A . n 
A 1 207 GLN 207 202 202 GLN GLN A . n 
A 1 208 THR 208 203 203 THR THR A . n 
A 1 209 VAL 209 204 204 VAL VAL A . n 
A 1 210 ASP 210 205 205 ASP ASP A . n 
A 1 211 ILE 211 206 206 ILE ILE A . n 
A 1 212 TRP 212 207 207 TRP TRP A . n 
A 1 213 SER 213 208 208 SER SER A . n 
A 1 214 VAL 214 209 209 VAL VAL A . n 
A 1 215 GLY 215 210 210 GLY GLY A . n 
A 1 216 CYS 216 211 211 CYS CYS A . n 
A 1 217 ILE 217 212 212 ILE ILE A . n 
A 1 218 MET 218 213 213 MET MET A . n 
A 1 219 ALA 219 214 214 ALA ALA A . n 
A 1 220 GLU 220 215 215 GLU GLU A . n 
A 1 221 LEU 221 216 216 LEU LEU A . n 
A 1 222 LEU 222 217 217 LEU LEU A . n 
A 1 223 THR 223 218 218 THR THR A . n 
A 1 224 GLY 224 219 219 GLY GLY A . n 
A 1 225 ARG 225 220 220 ARG ARG A . n 
A 1 226 THR 226 221 221 THR THR A . n 
A 1 227 LEU 227 222 222 LEU LEU A . n 
A 1 228 PHE 228 223 223 PHE PHE A . n 
A 1 229 PRO 229 224 224 PRO PRO A . n 
A 1 230 GLY 230 225 225 GLY GLY A . n 
A 1 231 THR 231 226 226 THR THR A . n 
A 1 232 ASP 232 227 227 ASP ASP A . n 
A 1 233 HIS 233 228 228 HIS HIS A . n 
A 1 234 ILE 234 229 229 ILE ILE A . n 
A 1 235 ASP 235 230 230 ASP ASP A . n 
A 1 236 GLN 236 231 231 GLN GLN A . n 
A 1 237 LEU 237 232 232 LEU LEU A . n 
A 1 238 LYS 238 233 233 LYS LYS A . n 
A 1 239 LEU 239 234 234 LEU LEU A . n 
A 1 240 ILE 240 235 235 ILE ILE A . n 
A 1 241 LEU 241 236 236 LEU LEU A . n 
A 1 242 ARG 242 237 237 ARG ARG A . n 
A 1 243 LEU 243 238 238 LEU LEU A . n 
A 1 244 VAL 244 239 239 VAL VAL A . n 
A 1 245 GLY 245 240 240 GLY GLY A . n 
A 1 246 THR 246 241 241 THR THR A . n 
A 1 247 PRO 247 242 242 PRO PRO A . n 
A 1 248 GLY 248 243 243 GLY GLY A . n 
A 1 249 ALA 249 244 244 ALA ALA A . n 
A 1 250 GLU 250 245 245 GLU GLU A . n 
A 1 251 LEU 251 246 246 LEU LEU A . n 
A 1 252 LEU 252 247 247 LEU LEU A . n 
A 1 253 LYS 253 248 248 LYS LYS A . n 
A 1 254 LYS 254 249 249 LYS LYS A . n 
A 1 255 ILE 255 250 250 ILE ILE A . n 
A 1 256 SER 256 251 251 SER SER A . n 
A 1 257 SER 257 252 252 SER SER A . n 
A 1 258 GLU 258 253 253 GLU GLU A . n 
A 1 259 SER 259 254 254 SER SER A . n 
A 1 260 ALA 260 255 255 ALA ALA A . n 
A 1 261 ARG 261 256 256 ARG ARG A . n 
A 1 262 ASN 262 257 257 ASN ASN A . n 
A 1 263 TYR 263 258 258 TYR TYR A . n 
A 1 264 ILE 264 259 259 ILE ILE A . n 
A 1 265 GLN 265 260 260 GLN GLN A . n 
A 1 266 SER 266 261 261 SER SER A . n 
A 1 267 LEU 267 262 262 LEU LEU A . n 
A 1 268 THR 268 263 263 THR THR A . n 
A 1 269 GLN 269 264 264 GLN GLN A . n 
A 1 270 MET 270 265 265 MET MET A . n 
A 1 271 PRO 271 266 266 PRO PRO A . n 
A 1 272 LYS 272 267 267 LYS LYS A . n 
A 1 273 MET 273 268 268 MET MET A . n 
A 1 274 ASN 274 269 269 ASN ASN A . n 
A 1 275 PHE 275 270 270 PHE PHE A . n 
A 1 276 ALA 276 271 271 ALA ALA A . n 
A 1 277 ASN 277 272 272 ASN ASN A . n 
A 1 278 VAL 278 273 273 VAL VAL A . n 
A 1 279 PHE 279 274 274 PHE PHE A . n 
A 1 280 ILE 280 275 275 ILE ILE A . n 
A 1 281 GLY 281 276 276 GLY GLY A . n 
A 1 282 ALA 282 277 277 ALA ALA A . n 
A 1 283 ASN 283 278 278 ASN ASN A . n 
A 1 284 PRO 284 279 279 PRO PRO A . n 
A 1 285 LEU 285 280 280 LEU LEU A . n 
A 1 286 ALA 286 281 281 ALA ALA A . n 
A 1 287 VAL 287 282 282 VAL VAL A . n 
A 1 288 ASP 288 283 283 ASP ASP A . n 
A 1 289 LEU 289 284 284 LEU LEU A . n 
A 1 290 LEU 290 285 285 LEU LEU A . n 
A 1 291 GLU 291 286 286 GLU GLU A . n 
A 1 292 LYS 292 287 287 LYS LYS A . n 
A 1 293 MET 293 288 288 MET MET A . n 
A 1 294 LEU 294 289 289 LEU LEU A . n 
A 1 295 VAL 295 290 290 VAL VAL A . n 
A 1 296 LEU 296 291 291 LEU LEU A . n 
A 1 297 ASP 297 292 292 ASP ASP A . n 
A 1 298 SER 298 293 293 SER SER A . n 
A 1 299 ASP 299 294 294 ASP ASP A . n 
A 1 300 LYS 300 295 295 LYS LYS A . n 
A 1 301 ARG 301 296 296 ARG ARG A . n 
A 1 302 ILE 302 297 297 ILE ILE A . n 
A 1 303 THR 303 298 298 THR THR A . n 
A 1 304 ALA 304 299 299 ALA ALA A . n 
A 1 305 ALA 305 300 300 ALA ALA A . n 
A 1 306 GLN 306 301 301 GLN GLN A . n 
A 1 307 ALA 307 302 302 ALA ALA A . n 
A 1 308 LEU 308 303 303 LEU LEU A . n 
A 1 309 ALA 309 304 304 ALA ALA A . n 
A 1 310 HIS 310 305 305 HIS HIS A . n 
A 1 311 ALA 311 306 306 ALA ALA A . n 
A 1 312 TYR 312 307 307 TYR TYR A . n 
A 1 313 PHE 313 308 308 PHE PHE A . n 
A 1 314 ALA 314 309 309 ALA ALA A . n 
A 1 315 GLN 315 310 310 GLN GLN A . n 
A 1 316 TYR 316 311 311 TYR TYR A . n 
A 1 317 HIS 317 312 312 HIS HIS A . n 
A 1 318 ASP 318 313 313 ASP ASP A . n 
A 1 319 PRO 319 314 314 PRO PRO A . n 
A 1 320 ASP 320 315 315 ASP ASP A . n 
A 1 321 ASP 321 316 316 ASP ASP A . n 
A 1 322 GLU 322 317 317 GLU GLU A . n 
A 1 323 PRO 323 318 318 PRO PRO A . n 
A 1 324 VAL 324 319 319 VAL VAL A . n 
A 1 325 ALA 325 320 320 ALA ALA A . n 
A 1 326 ASP 326 321 321 ASP ASP A . n 
A 1 327 PRO 327 322 322 PRO PRO A . n 
A 1 328 TYR 328 323 323 TYR TYR A . n 
A 1 329 ASP 329 324 324 ASP ASP A . n 
A 1 330 GLN 330 325 325 GLN GLN A . n 
A 1 331 SER 331 326 326 SER SER A . n 
A 1 332 PHE 332 327 327 PHE PHE A . n 
A 1 333 GLU 333 328 328 GLU GLU A . n 
A 1 334 SER 334 329 329 SER SER A . n 
A 1 335 ARG 335 330 330 ARG ARG A . n 
A 1 336 ASP 336 331 331 ASP ASP A . n 
A 1 337 LEU 337 332 332 LEU LEU A . n 
A 1 338 LEU 338 333 333 LEU LEU A . n 
A 1 339 ILE 339 334 334 ILE ILE A . n 
A 1 340 ASP 340 335 335 ASP ASP A . n 
A 1 341 GLU 341 336 336 GLU GLU A . n 
A 1 342 TRP 342 337 337 TRP TRP A . n 
A 1 343 LYS 343 338 338 LYS LYS A . n 
A 1 344 SER 344 339 339 SER SER A . n 
A 1 345 LEU 345 340 340 LEU LEU A . n 
A 1 346 THR 346 341 341 THR THR A . n 
A 1 347 TYR 347 342 342 TYR TYR A . n 
A 1 348 ASP 348 343 343 ASP ASP A . n 
A 1 349 GLU 349 344 344 GLU GLU A . n 
A 1 350 VAL 350 345 345 VAL VAL A . n 
A 1 351 ILE 351 346 346 ILE ILE A . n 
A 1 352 SER 352 347 347 SER SER A . n 
A 1 353 PHE 353 348 348 PHE PHE A . n 
A 1 354 VAL 354 349 349 VAL VAL A . n 
A 1 355 PRO 355 350 350 PRO PRO A . n 
A 1 356 PRO 356 351 351 PRO PRO A . n 
A 1 357 PRO 357 352 352 PRO PRO A . n 
A 1 358 LEU 358 353 353 LEU LEU A . n 
A 1 359 ASP 359 354 ?   ?   ?   A . n 
A 1 360 GLN 360 355 ?   ?   ?   A . n 
A 1 361 GLU 361 356 ?   ?   ?   A . n 
A 1 362 GLU 362 357 ?   ?   ?   A . n 
A 1 363 MET 363 358 ?   ?   ?   A . n 
A 1 364 GLU 364 359 ?   ?   ?   A . n 
A 1 365 SER 365 360 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 B8Z 1   401 401 B8Z HT2 A . 
C 3 HOH 1   501 451 HOH HOH A . 
C 3 HOH 2   502 479 HOH HOH A . 
C 3 HOH 3   503 463 HOH HOH A . 
C 3 HOH 4   504 487 HOH HOH A . 
C 3 HOH 5   505 470 HOH HOH A . 
C 3 HOH 6   506 478 HOH HOH A . 
C 3 HOH 7   507 251 HOH HOH A . 
C 3 HOH 8   508 126 HOH HOH A . 
C 3 HOH 9   509 386 HOH HOH A . 
C 3 HOH 10  510 93  HOH HOH A . 
C 3 HOH 11  511 485 HOH HOH A . 
C 3 HOH 12  512 51  HOH HOH A . 
C 3 HOH 13  513 259 HOH HOH A . 
C 3 HOH 14  514 460 HOH HOH A . 
C 3 HOH 15  515 46  HOH HOH A . 
C 3 HOH 16  516 369 HOH HOH A . 
C 3 HOH 17  517 489 HOH HOH A . 
C 3 HOH 18  518 469 HOH HOH A . 
C 3 HOH 19  519 111 HOH HOH A . 
C 3 HOH 20  520 471 HOH HOH A . 
C 3 HOH 21  521 329 HOH HOH A . 
C 3 HOH 22  522 192 HOH HOH A . 
C 3 HOH 23  523 419 HOH HOH A . 
C 3 HOH 24  524 25  HOH HOH A . 
C 3 HOH 25  525 274 HOH HOH A . 
C 3 HOH 26  526 417 HOH HOH A . 
C 3 HOH 27  527 243 HOH HOH A . 
C 3 HOH 28  528 373 HOH HOH A . 
C 3 HOH 29  529 8   HOH HOH A . 
C 3 HOH 30  530 267 HOH HOH A . 
C 3 HOH 31  531 64  HOH HOH A . 
C 3 HOH 32  532 66  HOH HOH A . 
C 3 HOH 33  533 281 HOH HOH A . 
C 3 HOH 34  534 12  HOH HOH A . 
C 3 HOH 35  535 389 HOH HOH A . 
C 3 HOH 36  536 392 HOH HOH A . 
C 3 HOH 37  537 5   HOH HOH A . 
C 3 HOH 38  538 271 HOH HOH A . 
C 3 HOH 39  539 183 HOH HOH A . 
C 3 HOH 40  540 348 HOH HOH A . 
C 3 HOH 41  541 74  HOH HOH A . 
C 3 HOH 42  542 249 HOH HOH A . 
C 3 HOH 43  543 142 HOH HOH A . 
C 3 HOH 44  544 139 HOH HOH A . 
C 3 HOH 45  545 387 HOH HOH A . 
C 3 HOH 46  546 378 HOH HOH A . 
C 3 HOH 47  547 241 HOH HOH A . 
C 3 HOH 48  548 256 HOH HOH A . 
C 3 HOH 49  549 376 HOH HOH A . 
C 3 HOH 50  550 346 HOH HOH A . 
C 3 HOH 51  551 121 HOH HOH A . 
C 3 HOH 52  552 456 HOH HOH A . 
C 3 HOH 53  553 382 HOH HOH A . 
C 3 HOH 54  554 189 HOH HOH A . 
C 3 HOH 55  555 100 HOH HOH A . 
C 3 HOH 56  556 350 HOH HOH A . 
C 3 HOH 57  557 133 HOH HOH A . 
C 3 HOH 58  558 260 HOH HOH A . 
C 3 HOH 59  559 4   HOH HOH A . 
C 3 HOH 60  560 6   HOH HOH A . 
C 3 HOH 61  561 174 HOH HOH A . 
C 3 HOH 62  562 374 HOH HOH A . 
C 3 HOH 63  563 323 HOH HOH A . 
C 3 HOH 64  564 125 HOH HOH A . 
C 3 HOH 65  565 80  HOH HOH A . 
C 3 HOH 66  566 7   HOH HOH A . 
C 3 HOH 67  567 261 HOH HOH A . 
C 3 HOH 68  568 109 HOH HOH A . 
C 3 HOH 69  569 240 HOH HOH A . 
C 3 HOH 70  570 86  HOH HOH A . 
C 3 HOH 71  571 149 HOH HOH A . 
C 3 HOH 72  572 19  HOH HOH A . 
C 3 HOH 73  573 55  HOH HOH A . 
C 3 HOH 74  574 90  HOH HOH A . 
C 3 HOH 75  575 170 HOH HOH A . 
C 3 HOH 76  576 263 HOH HOH A . 
C 3 HOH 77  577 445 HOH HOH A . 
C 3 HOH 78  578 147 HOH HOH A . 
C 3 HOH 79  579 92  HOH HOH A . 
C 3 HOH 80  580 338 HOH HOH A . 
C 3 HOH 81  581 31  HOH HOH A . 
C 3 HOH 82  582 219 HOH HOH A . 
C 3 HOH 83  583 436 HOH HOH A . 
C 3 HOH 84  584 319 HOH HOH A . 
C 3 HOH 85  585 160 HOH HOH A . 
C 3 HOH 86  586 89  HOH HOH A . 
C 3 HOH 87  587 191 HOH HOH A . 
C 3 HOH 88  588 304 HOH HOH A . 
C 3 HOH 89  589 222 HOH HOH A . 
C 3 HOH 90  590 383 HOH HOH A . 
C 3 HOH 91  591 163 HOH HOH A . 
C 3 HOH 92  592 361 HOH HOH A . 
C 3 HOH 93  593 114 HOH HOH A . 
C 3 HOH 94  594 132 HOH HOH A . 
C 3 HOH 95  595 206 HOH HOH A . 
C 3 HOH 96  596 141 HOH HOH A . 
C 3 HOH 97  597 297 HOH HOH A . 
C 3 HOH 98  598 42  HOH HOH A . 
C 3 HOH 99  599 262 HOH HOH A . 
C 3 HOH 100 600 119 HOH HOH A . 
C 3 HOH 101 601 60  HOH HOH A . 
C 3 HOH 102 602 305 HOH HOH A . 
C 3 HOH 103 603 40  HOH HOH A . 
C 3 HOH 104 604 299 HOH HOH A . 
C 3 HOH 105 605 154 HOH HOH A . 
C 3 HOH 106 606 63  HOH HOH A . 
C 3 HOH 107 607 18  HOH HOH A . 
C 3 HOH 108 608 178 HOH HOH A . 
C 3 HOH 109 609 58  HOH HOH A . 
C 3 HOH 110 610 143 HOH HOH A . 
C 3 HOH 111 611 105 HOH HOH A . 
C 3 HOH 112 612 186 HOH HOH A . 
C 3 HOH 113 613 85  HOH HOH A . 
C 3 HOH 114 614 24  HOH HOH A . 
C 3 HOH 115 615 16  HOH HOH A . 
C 3 HOH 116 616 404 HOH HOH A . 
C 3 HOH 117 617 129 HOH HOH A . 
C 3 HOH 118 618 223 HOH HOH A . 
C 3 HOH 119 619 146 HOH HOH A . 
C 3 HOH 120 620 233 HOH HOH A . 
C 3 HOH 121 621 403 HOH HOH A . 
C 3 HOH 122 622 257 HOH HOH A . 
C 3 HOH 123 623 466 HOH HOH A . 
C 3 HOH 124 624 134 HOH HOH A . 
C 3 HOH 125 625 3   HOH HOH A . 
C 3 HOH 126 626 33  HOH HOH A . 
C 3 HOH 127 627 232 HOH HOH A . 
C 3 HOH 128 628 30  HOH HOH A . 
C 3 HOH 129 629 166 HOH HOH A . 
C 3 HOH 130 630 115 HOH HOH A . 
C 3 HOH 131 631 306 HOH HOH A . 
C 3 HOH 132 632 17  HOH HOH A . 
C 3 HOH 133 633 26  HOH HOH A . 
C 3 HOH 134 634 131 HOH HOH A . 
C 3 HOH 135 635 425 HOH HOH A . 
C 3 HOH 136 636 128 HOH HOH A . 
C 3 HOH 137 637 37  HOH HOH A . 
C 3 HOH 138 638 94  HOH HOH A . 
C 3 HOH 139 639 188 HOH HOH A . 
C 3 HOH 140 640 164 HOH HOH A . 
C 3 HOH 141 641 140 HOH HOH A . 
C 3 HOH 142 642 48  HOH HOH A . 
C 3 HOH 143 643 122 HOH HOH A . 
C 3 HOH 144 644 420 HOH HOH A . 
C 3 HOH 145 645 88  HOH HOH A . 
C 3 HOH 146 646 135 HOH HOH A . 
C 3 HOH 147 647 118 HOH HOH A . 
C 3 HOH 148 648 148 HOH HOH A . 
C 3 HOH 149 649 106 HOH HOH A . 
C 3 HOH 150 650 103 HOH HOH A . 
C 3 HOH 151 651 1   HOH HOH A . 
C 3 HOH 152 652 156 HOH HOH A . 
C 3 HOH 153 653 229 HOH HOH A . 
C 3 HOH 154 654 462 HOH HOH A . 
C 3 HOH 155 655 226 HOH HOH A . 
C 3 HOH 156 656 107 HOH HOH A . 
C 3 HOH 157 657 282 HOH HOH A . 
C 3 HOH 158 658 272 HOH HOH A . 
C 3 HOH 159 659 464 HOH HOH A . 
C 3 HOH 160 660 218 HOH HOH A . 
C 3 HOH 161 661 210 HOH HOH A . 
C 3 HOH 162 662 333 HOH HOH A . 
C 3 HOH 163 663 347 HOH HOH A . 
C 3 HOH 164 664 275 HOH HOH A . 
C 3 HOH 165 665 236 HOH HOH A . 
C 3 HOH 166 666 98  HOH HOH A . 
C 3 HOH 167 667 202 HOH HOH A . 
C 3 HOH 168 668 102 HOH HOH A . 
C 3 HOH 169 669 15  HOH HOH A . 
C 3 HOH 170 670 82  HOH HOH A . 
C 3 HOH 171 671 324 HOH HOH A . 
C 3 HOH 172 672 91  HOH HOH A . 
C 3 HOH 173 673 359 HOH HOH A . 
C 3 HOH 174 674 410 HOH HOH A . 
C 3 HOH 175 675 117 HOH HOH A . 
C 3 HOH 176 676 87  HOH HOH A . 
C 3 HOH 177 677 342 HOH HOH A . 
C 3 HOH 178 678 108 HOH HOH A . 
C 3 HOH 179 679 295 HOH HOH A . 
C 3 HOH 180 680 429 HOH HOH A . 
C 3 HOH 181 681 127 HOH HOH A . 
C 3 HOH 182 682 112 HOH HOH A . 
C 3 HOH 183 683 28  HOH HOH A . 
C 3 HOH 184 684 298 HOH HOH A . 
C 3 HOH 185 685 482 HOH HOH A . 
C 3 HOH 186 686 278 HOH HOH A . 
C 3 HOH 187 687 137 HOH HOH A . 
C 3 HOH 188 688 215 HOH HOH A . 
C 3 HOH 189 689 302 HOH HOH A . 
C 3 HOH 190 690 59  HOH HOH A . 
C 3 HOH 191 691 14  HOH HOH A . 
C 3 HOH 192 692 172 HOH HOH A . 
C 3 HOH 193 693 435 HOH HOH A . 
C 3 HOH 194 694 104 HOH HOH A . 
C 3 HOH 195 695 250 HOH HOH A . 
C 3 HOH 196 696 353 HOH HOH A . 
C 3 HOH 197 697 168 HOH HOH A . 
C 3 HOH 198 698 253 HOH HOH A . 
C 3 HOH 199 699 43  HOH HOH A . 
C 3 HOH 200 700 145 HOH HOH A . 
C 3 HOH 201 701 352 HOH HOH A . 
C 3 HOH 202 702 120 HOH HOH A . 
C 3 HOH 203 703 96  HOH HOH A . 
C 3 HOH 204 704 355 HOH HOH A . 
C 3 HOH 205 705 130 HOH HOH A . 
C 3 HOH 206 706 110 HOH HOH A . 
C 3 HOH 207 707 150 HOH HOH A . 
C 3 HOH 208 708 402 HOH HOH A . 
C 3 HOH 209 709 428 HOH HOH A . 
C 3 HOH 210 710 57  HOH HOH A . 
C 3 HOH 211 711 409 HOH HOH A . 
C 3 HOH 212 712 136 HOH HOH A . 
C 3 HOH 213 713 459 HOH HOH A . 
C 3 HOH 214 714 155 HOH HOH A . 
C 3 HOH 215 715 35  HOH HOH A . 
C 3 HOH 216 716 365 HOH HOH A . 
C 3 HOH 217 717 395 HOH HOH A . 
C 3 HOH 218 718 11  HOH HOH A . 
C 3 HOH 219 719 76  HOH HOH A . 
C 3 HOH 220 720 195 HOH HOH A . 
C 3 HOH 221 721 310 HOH HOH A . 
C 3 HOH 222 722 27  HOH HOH A . 
C 3 HOH 223 723 467 HOH HOH A . 
C 3 HOH 224 724 54  HOH HOH A . 
C 3 HOH 225 725 311 HOH HOH A . 
C 3 HOH 226 726 351 HOH HOH A . 
C 3 HOH 227 727 335 HOH HOH A . 
C 3 HOH 228 728 440 HOH HOH A . 
C 3 HOH 229 729 97  HOH HOH A . 
C 3 HOH 230 730 197 HOH HOH A . 
C 3 HOH 231 731 411 HOH HOH A . 
C 3 HOH 232 732 336 HOH HOH A . 
C 3 HOH 233 733 45  HOH HOH A . 
C 3 HOH 234 734 36  HOH HOH A . 
C 3 HOH 235 735 116 HOH HOH A . 
C 3 HOH 236 736 61  HOH HOH A . 
C 3 HOH 237 737 258 HOH HOH A . 
C 3 HOH 238 738 360 HOH HOH A . 
C 3 HOH 239 739 390 HOH HOH A . 
C 3 HOH 240 740 439 HOH HOH A . 
C 3 HOH 241 741 194 HOH HOH A . 
C 3 HOH 242 742 337 HOH HOH A . 
C 3 HOH 243 743 123 HOH HOH A . 
C 3 HOH 244 744 47  HOH HOH A . 
C 3 HOH 245 745 277 HOH HOH A . 
C 3 HOH 246 746 309 HOH HOH A . 
C 3 HOH 247 747 124 HOH HOH A . 
C 3 HOH 248 748 159 HOH HOH A . 
C 3 HOH 249 749 458 HOH HOH A . 
C 3 HOH 250 750 182 HOH HOH A . 
C 3 HOH 251 751 483 HOH HOH A . 
C 3 HOH 252 752 318 HOH HOH A . 
C 3 HOH 253 753 266 HOH HOH A . 
C 3 HOH 254 754 322 HOH HOH A . 
C 3 HOH 255 755 32  HOH HOH A . 
C 3 HOH 256 756 22  HOH HOH A . 
C 3 HOH 257 757 421 HOH HOH A . 
C 3 HOH 258 758 270 HOH HOH A . 
C 3 HOH 259 759 84  HOH HOH A . 
C 3 HOH 260 760 99  HOH HOH A . 
C 3 HOH 261 761 468 HOH HOH A . 
C 3 HOH 262 762 83  HOH HOH A . 
C 3 HOH 263 763 407 HOH HOH A . 
C 3 HOH 264 764 388 HOH HOH A . 
C 3 HOH 265 765 422 HOH HOH A . 
C 3 HOH 266 766 68  HOH HOH A . 
C 3 HOH 267 767 79  HOH HOH A . 
C 3 HOH 268 768 221 HOH HOH A . 
C 3 HOH 269 769 461 HOH HOH A . 
C 3 HOH 270 770 177 HOH HOH A . 
C 3 HOH 271 771 34  HOH HOH A . 
C 3 HOH 272 772 21  HOH HOH A . 
C 3 HOH 273 773 246 HOH HOH A . 
C 3 HOH 274 774 465 HOH HOH A . 
C 3 HOH 275 775 101 HOH HOH A . 
C 3 HOH 276 776 169 HOH HOH A . 
C 3 HOH 277 777 181 HOH HOH A . 
C 3 HOH 278 778 315 HOH HOH A . 
C 3 HOH 279 779 300 HOH HOH A . 
C 3 HOH 280 780 23  HOH HOH A . 
C 3 HOH 281 781 433 HOH HOH A . 
C 3 HOH 282 782 65  HOH HOH A . 
C 3 HOH 283 783 173 HOH HOH A . 
C 3 HOH 284 784 415 HOH HOH A . 
C 3 HOH 285 785 371 HOH HOH A . 
C 3 HOH 286 786 454 HOH HOH A . 
C 3 HOH 287 787 289 HOH HOH A . 
C 3 HOH 288 788 349 HOH HOH A . 
C 3 HOH 289 789 244 HOH HOH A . 
C 3 HOH 290 790 72  HOH HOH A . 
C 3 HOH 291 791 238 HOH HOH A . 
C 3 HOH 292 792 144 HOH HOH A . 
C 3 HOH 293 793 201 HOH HOH A . 
C 3 HOH 294 794 234 HOH HOH A . 
C 3 HOH 295 795 472 HOH HOH A . 
C 3 HOH 296 796 327 HOH HOH A . 
C 3 HOH 297 797 434 HOH HOH A . 
C 3 HOH 298 798 328 HOH HOH A . 
C 3 HOH 299 799 9   HOH HOH A . 
C 3 HOH 300 800 230 HOH HOH A . 
C 3 HOH 301 801 339 HOH HOH A . 
C 3 HOH 302 802 204 HOH HOH A . 
C 3 HOH 303 803 357 HOH HOH A . 
C 3 HOH 304 804 95  HOH HOH A . 
C 3 HOH 305 805 252 HOH HOH A . 
C 3 HOH 306 806 81  HOH HOH A . 
C 3 HOH 307 807 227 HOH HOH A . 
C 3 HOH 308 808 308 HOH HOH A . 
C 3 HOH 309 809 38  HOH HOH A . 
C 3 HOH 310 810 13  HOH HOH A . 
C 3 HOH 311 811 44  HOH HOH A . 
C 3 HOH 312 812 187 HOH HOH A . 
C 3 HOH 313 813 205 HOH HOH A . 
C 3 HOH 314 814 430 HOH HOH A . 
C 3 HOH 315 815 286 HOH HOH A . 
C 3 HOH 316 816 414 HOH HOH A . 
C 3 HOH 317 817 214 HOH HOH A . 
C 3 HOH 318 818 185 HOH HOH A . 
C 3 HOH 319 819 69  HOH HOH A . 
C 3 HOH 320 820 184 HOH HOH A . 
C 3 HOH 321 821 423 HOH HOH A . 
C 3 HOH 322 822 344 HOH HOH A . 
C 3 HOH 323 823 280 HOH HOH A . 
C 3 HOH 324 824 255 HOH HOH A . 
C 3 HOH 325 825 283 HOH HOH A . 
C 3 HOH 326 826 157 HOH HOH A . 
C 3 HOH 327 827 213 HOH HOH A . 
C 3 HOH 328 828 77  HOH HOH A . 
C 3 HOH 329 829 391 HOH HOH A . 
C 3 HOH 330 830 67  HOH HOH A . 
C 3 HOH 331 831 265 HOH HOH A . 
C 3 HOH 332 832 484 HOH HOH A . 
C 3 HOH 333 833 41  HOH HOH A . 
C 3 HOH 334 834 212 HOH HOH A . 
C 3 HOH 335 835 231 HOH HOH A . 
C 3 HOH 336 836 418 HOH HOH A . 
C 3 HOH 337 837 393 HOH HOH A . 
C 3 HOH 338 838 377 HOH HOH A . 
C 3 HOH 339 839 358 HOH HOH A . 
C 3 HOH 340 840 375 HOH HOH A . 
C 3 HOH 341 841 384 HOH HOH A . 
C 3 HOH 342 842 70  HOH HOH A . 
C 3 HOH 343 843 457 HOH HOH A . 
C 3 HOH 344 844 330 HOH HOH A . 
C 3 HOH 345 845 193 HOH HOH A . 
C 3 HOH 346 846 397 HOH HOH A . 
C 3 HOH 347 847 441 HOH HOH A . 
C 3 HOH 348 848 455 HOH HOH A . 
C 3 HOH 349 849 307 HOH HOH A . 
C 3 HOH 350 850 287 HOH HOH A . 
C 3 HOH 351 851 366 HOH HOH A . 
C 3 HOH 352 852 343 HOH HOH A . 
C 3 HOH 353 853 367 HOH HOH A . 
C 3 HOH 354 854 293 HOH HOH A . 
C 3 HOH 355 855 29  HOH HOH A . 
C 3 HOH 356 856 452 HOH HOH A . 
C 3 HOH 357 857 196 HOH HOH A . 
C 3 HOH 358 858 50  HOH HOH A . 
C 3 HOH 359 859 408 HOH HOH A . 
C 3 HOH 360 860 71  HOH HOH A . 
C 3 HOH 361 861 340 HOH HOH A . 
C 3 HOH 362 862 153 HOH HOH A . 
C 3 HOH 363 863 73  HOH HOH A . 
C 3 HOH 364 864 312 HOH HOH A . 
C 3 HOH 365 865 203 HOH HOH A . 
C 3 HOH 366 866 474 HOH HOH A . 
C 3 HOH 367 867 113 HOH HOH A . 
C 3 HOH 368 868 199 HOH HOH A . 
C 3 HOH 369 869 326 HOH HOH A . 
C 3 HOH 370 870 190 HOH HOH A . 
C 3 HOH 371 871 316 HOH HOH A . 
C 3 HOH 372 872 198 HOH HOH A . 
C 3 HOH 373 873 432 HOH HOH A . 
C 3 HOH 374 874 294 HOH HOH A . 
C 3 HOH 375 875 264 HOH HOH A . 
C 3 HOH 376 876 412 HOH HOH A . 
C 3 HOH 377 877 62  HOH HOH A . 
C 3 HOH 378 878 161 HOH HOH A . 
C 3 HOH 379 879 453 HOH HOH A . 
C 3 HOH 380 880 180 HOH HOH A . 
C 3 HOH 381 881 321 HOH HOH A . 
C 3 HOH 382 882 486 HOH HOH A . 
C 3 HOH 383 883 53  HOH HOH A . 
C 3 HOH 384 884 313 HOH HOH A . 
C 3 HOH 385 885 211 HOH HOH A . 
C 3 HOH 386 886 406 HOH HOH A . 
C 3 HOH 387 887 138 HOH HOH A . 
C 3 HOH 388 888 200 HOH HOH A . 
C 3 HOH 389 889 171 HOH HOH A . 
C 3 HOH 390 890 291 HOH HOH A . 
C 3 HOH 391 891 334 HOH HOH A . 
C 3 HOH 392 892 179 HOH HOH A . 
C 3 HOH 393 893 331 HOH HOH A . 
C 3 HOH 394 894 405 HOH HOH A . 
C 3 HOH 395 895 279 HOH HOH A . 
C 3 HOH 396 896 475 HOH HOH A . 
C 3 HOH 397 897 165 HOH HOH A . 
C 3 HOH 398 898 151 HOH HOH A . 
C 3 HOH 399 899 56  HOH HOH A . 
C 3 HOH 400 900 52  HOH HOH A . 
C 3 HOH 401 901 273 HOH HOH A . 
C 3 HOH 402 902 380 HOH HOH A . 
C 3 HOH 403 903 285 HOH HOH A . 
C 3 HOH 404 904 152 HOH HOH A . 
C 3 HOH 405 905 320 HOH HOH A . 
C 3 HOH 406 906 368 HOH HOH A . 
C 3 HOH 407 907 239 HOH HOH A . 
C 3 HOH 408 908 75  HOH HOH A . 
C 3 HOH 409 909 268 HOH HOH A . 
C 3 HOH 410 910 416 HOH HOH A . 
C 3 HOH 411 911 426 HOH HOH A . 
C 3 HOH 412 912 162 HOH HOH A . 
C 3 HOH 413 913 242 HOH HOH A . 
C 3 HOH 414 914 296 HOH HOH A . 
C 3 HOH 415 915 207 HOH HOH A . 
C 3 HOH 416 916 176 HOH HOH A . 
C 3 HOH 417 917 372 HOH HOH A . 
C 3 HOH 418 918 78  HOH HOH A . 
C 3 HOH 419 919 363 HOH HOH A . 
C 3 HOH 420 920 385 HOH HOH A . 
C 3 HOH 421 921 235 HOH HOH A . 
C 3 HOH 422 922 303 HOH HOH A . 
C 3 HOH 423 923 314 HOH HOH A . 
C 3 HOH 424 924 442 HOH HOH A . 
C 3 HOH 425 925 488 HOH HOH A . 
C 3 HOH 426 926 276 HOH HOH A . 
C 3 HOH 427 927 208 HOH HOH A . 
C 3 HOH 428 928 413 HOH HOH A . 
C 3 HOH 429 929 269 HOH HOH A . 
C 3 HOH 430 930 216 HOH HOH A . 
C 3 HOH 431 931 379 HOH HOH A . 
C 3 HOH 432 932 325 HOH HOH A . 
C 3 HOH 433 933 290 HOH HOH A . 
C 3 HOH 434 934 20  HOH HOH A . 
C 3 HOH 435 935 2   HOH HOH A . 
C 3 HOH 436 936 332 HOH HOH A . 
C 3 HOH 437 937 217 HOH HOH A . 
C 3 HOH 438 938 292 HOH HOH A . 
C 3 HOH 439 939 224 HOH HOH A . 
C 3 HOH 440 940 158 HOH HOH A . 
C 3 HOH 441 941 480 HOH HOH A . 
C 3 HOH 442 942 473 HOH HOH A . 
C 3 HOH 443 943 49  HOH HOH A . 
C 3 HOH 444 944 381 HOH HOH A . 
C 3 HOH 445 945 228 HOH HOH A . 
C 3 HOH 446 946 354 HOH HOH A . 
C 3 HOH 447 947 175 HOH HOH A . 
C 3 HOH 448 948 356 HOH HOH A . 
C 3 HOH 449 949 424 HOH HOH A . 
C 3 HOH 450 950 341 HOH HOH A . 
C 3 HOH 451 951 362 HOH HOH A . 
C 3 HOH 452 952 254 HOH HOH A . 
C 3 HOH 453 953 237 HOH HOH A . 
C 3 HOH 454 954 225 HOH HOH A . 
C 3 HOH 455 955 209 HOH HOH A . 
C 3 HOH 456 956 400 HOH HOH A . 
C 3 HOH 457 957 245 HOH HOH A . 
C 3 HOH 458 958 39  HOH HOH A . 
C 3 HOH 459 959 394 HOH HOH A . 
C 3 HOH 460 960 10  HOH HOH A . 
C 3 HOH 461 961 284 HOH HOH A . 
C 3 HOH 462 962 220 HOH HOH A . 
C 3 HOH 463 963 345 HOH HOH A . 
C 3 HOH 464 964 167 HOH HOH A . 
C 3 HOH 465 965 301 HOH HOH A . 
C 3 HOH 466 966 396 HOH HOH A . 
C 3 HOH 467 967 477 HOH HOH A . 
C 3 HOH 468 968 444 HOH HOH A . 
C 3 HOH 469 969 399 HOH HOH A . 
C 3 HOH 470 970 288 HOH HOH A . 
C 3 HOH 471 971 427 HOH HOH A . 
C 3 HOH 472 972 431 HOH HOH A . 
C 3 HOH 473 973 247 HOH HOH A . 
C 3 HOH 474 974 401 HOH HOH A . 
C 3 HOH 475 975 370 HOH HOH A . 
C 3 HOH 476 976 481 HOH HOH A . 
C 3 HOH 477 977 476 HOH HOH A . 
C 3 HOH 478 978 248 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8X3M 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.366 
_cell.length_a_esd                 ? 
_cell.length_b                     85.500 
_cell.length_b_esd                 ? 
_cell.length_c                     125.669 
_cell.length_c_esd                 ? 
_cell.volume                       487444.038 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8X3M 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8X3M 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.95 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          58.35 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Ammonium acetate, 0.1M HEPES pH7.5, 15% w/v PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-02-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    mirrors 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL44XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL44XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          41.81 
_reflns.entry_id                                       8X3M 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.85 
_reflns.d_resolution_low                               42.75 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     39303 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           91.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.99 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.067 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.85 
_reflns_shell.d_res_low                                     1.96 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             39303 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.997 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          91.6 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.067 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               53.05 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8X3M 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.85 
_refine.ls_d_res_low                             42.75 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     39260 
_refine.ls_number_reflns_R_free                  1962 
_refine.ls_number_reflns_R_work                  37298 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    91.64 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1833 
_refine.ls_R_factor_R_free                       0.2257 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1811 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.4198 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2785 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.85 
_refine_hist.d_res_low                        42.75 
_refine_hist.number_atoms_solvent             478 
_refine_hist.number_atoms_total               3333 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2825 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         30 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0126 ? 3220 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0418 ? 4405 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0652 ? 485  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0091 ? 570  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 8.3158 ? 443  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.85 1.89  . . 127 2392 82.62 . . . . 0.3862 . . . . . . . . . . . 0.4235 
'X-RAY DIFFRACTION' 1.89 1.94  . . 130 2497 88.30 . . . . 0.3101 . . . . . . . . . . . 0.3733 
'X-RAY DIFFRACTION' 1.94 2.00  . . 130 2457 86.03 . . . . 0.2803 . . . . . . . . . . . 0.2806 
'X-RAY DIFFRACTION' 2.00 2.07  . . 131 2499 86.26 . . . . 0.2496 . . . . . . . . . . . 0.3181 
'X-RAY DIFFRACTION' 2.07 2.14  . . 133 2523 88.74 . . . . 0.2443 . . . . . . . . . . . 0.2815 
'X-RAY DIFFRACTION' 2.14 2.23  . . 133 2524 88.04 . . . . 0.2203 . . . . . . . . . . . 0.2741 
'X-RAY DIFFRACTION' 2.23 2.33  . . 138 2627 90.80 . . . . 0.2047 . . . . . . . . . . . 0.2696 
'X-RAY DIFFRACTION' 2.33 2.45  . . 138 2626 91.34 . . . . 0.1978 . . . . . . . . . . . 0.2578 
'X-RAY DIFFRACTION' 2.45 2.60  . . 143 2712 93.27 . . . . 0.2000 . . . . . . . . . . . 0.2485 
'X-RAY DIFFRACTION' 2.60 2.80  . . 144 2731 94.45 . . . . 0.2009 . . . . . . . . . . . 0.2261 
'X-RAY DIFFRACTION' 2.80 3.09  . . 147 2788 95.66 . . . . 0.1963 . . . . . . . . . . . 0.2395 
'X-RAY DIFFRACTION' 3.09 3.53  . . 151 2893 98.16 . . . . 0.1699 . . . . . . . . . . . 0.2036 
'X-RAY DIFFRACTION' 3.53 4.45  . . 155 2956 99.42 . . . . 0.1400 . . . . . . . . . . . 0.1762 
'X-RAY DIFFRACTION' 4.45 42.75 . . 162 3073 98.69 . . . . 0.1692 . . . . . . . . . . . 0.2303 
# 
_struct.entry_id                     8X3M 
_struct.title                        'Crystal structure of p38alpha with an allosteric inhibitor 2' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8X3M 
_struct_keywords.text            'protein kinase MAPK family allosteric inhibitor covalent bond, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    MK14_HUMAN 
_struct_ref.pdbx_db_accession          Q16539 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH
ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA
DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8X3M 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 6 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 365 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q16539 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  360 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       360 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8X3M GLY A 1 ? UNP Q16539 ? ? 'expression tag' -4 1 
1 8X3M PRO A 2 ? UNP Q16539 ? ? 'expression tag' -3 2 
1 8X3M LEU A 3 ? UNP Q16539 ? ? 'expression tag' -2 3 
1 8X3M GLY A 4 ? UNP Q16539 ? ? 'expression tag' -1 4 
1 8X3M SER A 5 ? UNP Q16539 ? ? 'expression tag' 0  5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 66  ? MET A 83  ? SER A 61  MET A 78  1 ? 18 
HELX_P HELX_P2  AA2 ASP A 117 ? LYS A 123 ? ASP A 112 LYS A 118 1 ? 7  
HELX_P HELX_P3  AA3 THR A 128 ? ALA A 149 ? THR A 123 ALA A 144 1 ? 22 
HELX_P HELX_P4  AA4 LYS A 157 ? SER A 159 ? LYS A 152 SER A 154 5 ? 3  
HELX_P HELX_P5  AA5 ASP A 181 ? THR A 185 ? ASP A 176 THR A 180 5 ? 5  
HELX_P HELX_P6  AA6 VAL A 188 ? TYR A 193 ? VAL A 183 TYR A 188 1 ? 6  
HELX_P HELX_P7  AA7 ALA A 195 ? LEU A 200 ? ALA A 190 LEU A 195 1 ? 6  
HELX_P HELX_P8  AA8 GLN A 207 ? GLY A 224 ? GLN A 202 GLY A 219 1 ? 18 
HELX_P HELX_P9  AA9 ASP A 232 ? GLY A 245 ? ASP A 227 GLY A 240 1 ? 14 
HELX_P HELX_P10 AB1 GLY A 248 ? ILE A 255 ? GLY A 243 ILE A 250 1 ? 8  
HELX_P HELX_P11 AB2 SER A 257 ? GLN A 265 ? SER A 252 GLN A 260 1 ? 9  
HELX_P HELX_P12 AB3 ASN A 274 ? PHE A 279 ? ASN A 269 PHE A 274 1 ? 6  
HELX_P HELX_P13 AB4 ASN A 283 ? LEU A 294 ? ASN A 278 LEU A 289 1 ? 12 
HELX_P HELX_P14 AB5 ASP A 297 ? ARG A 301 ? ASP A 292 ARG A 296 5 ? 5  
HELX_P HELX_P15 AB6 THR A 303 ? ALA A 309 ? THR A 298 ALA A 304 1 ? 7  
HELX_P HELX_P16 AB7 HIS A 310 ? ALA A 314 ? HIS A 305 ALA A 309 5 ? 5  
HELX_P HELX_P17 AB8 ASP A 318 ? GLU A 322 ? ASP A 313 GLU A 317 5 ? 5  
HELX_P HELX_P18 AB9 GLN A 330 ? ARG A 335 ? GLN A 325 ARG A 330 5 ? 6  
HELX_P HELX_P19 AC1 LEU A 338 ? SER A 352 ? LEU A 333 SER A 347 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A CYS 167 SG ? ? ? 1_555 B B8Z . C27 A ? A CYS 162 A B8Z 401 1_555 ? ? ? ? ? ? ? 1.767 ? ? 
covale2 covale none ? A CYS 167 SG ? ? ? 1_555 B B8Z . C27 B ? A CYS 162 A B8Z 401 1_555 ? ? ? ? ? ? ? 1.767 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 B8Z B . A CYS A 167 ? B8Z A 401 ? 1_555 CYS A 162 ? 1_555 C27 SG CYS 1 B8Z None 'Covalent chemical modification' 
2 B8Z B . B CYS A 167 ? B8Z A 401 ? 1_555 CYS A 162 ? 1_555 C27 SG CYS 1 B8Z None 'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 5 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 13  ? GLN A 16  ? PHE A 8   GLN A 11  
AA1 2 TRP A 23  ? PRO A 26  ? TRP A 18  PRO A 21  
AA2 1 TYR A 29  ? GLY A 36  ? TYR A 24  GLY A 31  
AA2 2 GLY A 41  ? ASP A 48  ? GLY A 36  ASP A 43  
AA2 3 ARG A 54  ? LEU A 60  ? ARG A 49  LEU A 55  
AA2 4 TYR A 108 ? HIS A 112 ? TYR A 103 HIS A 107 
AA2 5 ASP A 93  ? PHE A 95  ? ASP A 88  PHE A 90  
AA3 1 LEU A 161 ? VAL A 163 ? LEU A 156 VAL A 158 
AA3 2 LEU A 169 ? ILE A 171 ? LEU A 164 ILE A 166 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 16  ? N GLN A 11  O TRP A 23  ? O TRP A 18  
AA2 1 2 N GLY A 36  ? N GLY A 31  O VAL A 43  ? O VAL A 38  
AA2 2 3 N CYS A 44  ? N CYS A 39  O VAL A 57  ? O VAL A 52  
AA2 3 4 N LYS A 58  ? N LYS A 53  O LEU A 109 ? O LEU A 104 
AA2 4 5 O VAL A 110 ? O VAL A 105 N ASP A 93  ? N ASP A 88  
AA3 1 2 N ALA A 162 ? N ALA A 157 O LYS A 170 ? O LYS A 165 
# 
_pdbx_entry_details.entry_id                   8X3M 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   A PRO 318 ? ? O  A HOH 501 ? ? 1.83 
2  1 O   A HOH 898 ? ? O  A HOH 911 ? ? 1.95 
3  1 O   A HOH 504 ? ? O  A HOH 541 ? ? 1.96 
4  1 O   A HOH 616 ? ? O  A HOH 783 ? ? 1.98 
5  1 O   A HOH 545 ? ? O  A HOH 624 ? ? 1.99 
6  1 O   A HOH 638 ? ? O  A HOH 876 ? ? 1.99 
7  1 O   A LEU 167 ? ? O  A HOH 502 ? ? 2.03 
8  1 O   A HOH 652 ? ? O  A HOH 738 ? ? 2.03 
9  1 O   A HOH 746 ? ? O  A HOH 772 ? ? 2.06 
10 1 NH1 A ARG 149 ? ? OH A TYR 200 ? ? 2.08 
11 1 NZ  A LYS 79  ? ? O  A HOH 503 ? ? 2.08 
12 1 NZ  A LYS 267 ? ? O  A HOH 504 ? ? 2.11 
13 1 O   A HOH 696 ? ? O  A HOH 828 ? ? 2.14 
14 1 O   A HOH 765 ? ? O  A HOH 912 ? ? 2.14 
15 1 OE1 A GLU 215 ? ? O  A HOH 505 ? ? 2.16 
16 1 O   A HOH 552 ? ? O  A HOH 903 ? ? 2.16 
17 1 O   A HIS 148 ? ? O  A HOH 506 ? ? 2.17 
18 1 O   A HOH 524 ? ? O  A HOH 737 ? ? 2.19 
19 1 O   A HOH 750 ? ? O  A HOH 947 ? ? 2.19 
20 1 O   A HOH 515 ? ? O  A HOH 733 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU A 13  ? A 52.86   -145.89 
2  1 LEU A 13  ? B 55.86   -89.79  
3  1 ASN A 14  ? A -45.19  -86.96  
4  1 ASN A 14  ? B -152.08 -59.37  
5  1 ASN A 100 ? ? -142.02 -27.25  
6  1 MET A 109 ? B -85.92  -70.61  
7  1 LYS A 118 ? ? -114.22 58.54   
8  1 CYS A 119 ? ? 173.06  9.52    
9  1 ARG A 149 ? ? 79.95   -8.82   
10 1 ASP A 168 ? A 71.62   -88.99  
11 1 ASP A 168 ? B 73.50   97.29   
12 1 PHE A 169 ? A 88.00   131.81  
13 1 ALA A 172 ? A 156.05  44.91   
14 1 ALA A 172 ? B 71.87   -42.26  
15 1 ARG A 173 ? A -98.07  -116.59 
16 1 HIS A 174 ? A 44.71   86.12   
17 1 PHE A 274 ? ? -102.30 63.45   
18 1 PHE A 274 ? ? -104.73 63.45   
19 1 ASN A 278 ? ? -38.73  121.41  
20 1 LEU A 289 ? ? -97.58  58.86   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1  1 O ? A HOH 965 ? 6.28  .    
2  1 O ? A HOH 966 ? 6.35  .    
3  1 O ? A HOH 967 ? 6.67  .    
4  1 O ? A HOH 968 ? 6.71  .    
5  1 O ? A HOH 969 ? 6.81  .    
6  1 O ? A HOH 970 ? 6.83  .    
7  1 O ? A HOH 971 ? 6.86  .    
8  1 O ? A HOH 972 ? 7.18  .    
9  1 O ? A HOH 973 ? .     7.67 
10 1 O ? A HOH 974 ? 8.64  .    
11 1 O ? A HOH 975 ? 8.72  .    
12 1 O ? A HOH 976 ? 9.10  .    
13 1 O ? A HOH 977 ? 9.80  .    
14 1 O ? A HOH 978 ? 13.04 .    
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY -4  ? A GLY 1   
2  1 Y 1 A PRO -3  ? A PRO 2   
3  1 Y 1 A LEU -2  ? A LEU 3   
4  1 Y 1 A GLY -1  ? A GLY 4   
5  1 Y 1 A SER 0   ? A SER 5   
6  1 Y 1 A MET 1   ? A MET 6   
7  1 Y 1 A SER 2   ? A SER 7   
8  1 Y 1 A GLN 3   ? A GLN 8   
9  1 Y 1 A ASP 354 ? A ASP 359 
10 1 Y 1 A GLN 355 ? A GLN 360 
11 1 Y 1 A GLU 356 ? A GLU 361 
12 1 Y 1 A GLU 357 ? A GLU 362 
13 1 Y 1 A MET 358 ? A MET 363 
14 1 Y 1 A GLU 359 ? A GLU 364 
15 1 Y 1 A SER 360 ? A SER 365 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
B8Z C11  C Y N 74  
B8Z C12  C Y N 75  
B8Z C14  C Y N 76  
B8Z C15  C N N 77  
B8Z C17  C Y N 78  
B8Z C18  C Y N 79  
B8Z C19  C Y N 80  
B8Z C20  C Y N 81  
B8Z C22  C Y N 82  
B8Z C01  C N N 83  
B8Z C03  C Y N 84  
B8Z C04  C Y N 85  
B8Z C05  C Y N 86  
B8Z C07  C Y N 87  
B8Z C09  C N N 88  
B8Z C23  C Y N 89  
B8Z C26  C Y N 90  
B8Z C27  C Y N 91  
B8Z C28  C Y N 92  
B8Z C30  C N N 93  
B8Z F21  F N N 94  
B8Z N06  N Y N 95  
B8Z N08  N N N 96  
B8Z N24  N Y N 97  
B8Z O02  O N N 98  
B8Z O10  O N N 99  
B8Z O16  O N N 100 
B8Z O29  O N N 101 
B8Z S13  S Y N 102 
B8Z S25  S Y N 103 
B8Z H1   H N N 104 
B8Z H2   H N N 105 
B8Z H3   H N N 106 
B8Z H4   H N N 107 
B8Z H5   H N N 108 
B8Z H6   H N N 109 
B8Z H7   H N N 110 
B8Z H8   H N N 111 
B8Z H9   H N N 112 
B8Z H10  H N N 113 
B8Z H11  H N N 114 
B8Z H12  H N N 115 
B8Z H13  H N N 116 
B8Z H14  H N N 117 
B8Z H15  H N N 118 
B8Z H16  H N N 119 
CYS N    N N N 120 
CYS CA   C N R 121 
CYS C    C N N 122 
CYS O    O N N 123 
CYS CB   C N N 124 
CYS SG   S N N 125 
CYS OXT  O N N 126 
CYS H    H N N 127 
CYS H2   H N N 128 
CYS HA   H N N 129 
CYS HB2  H N N 130 
CYS HB3  H N N 131 
CYS HG   H N N 132 
CYS HXT  H N N 133 
GLN N    N N N 134 
GLN CA   C N S 135 
GLN C    C N N 136 
GLN O    O N N 137 
GLN CB   C N N 138 
GLN CG   C N N 139 
GLN CD   C N N 140 
GLN OE1  O N N 141 
GLN NE2  N N N 142 
GLN OXT  O N N 143 
GLN H    H N N 144 
GLN H2   H N N 145 
GLN HA   H N N 146 
GLN HB2  H N N 147 
GLN HB3  H N N 148 
GLN HG2  H N N 149 
GLN HG3  H N N 150 
GLN HE21 H N N 151 
GLN HE22 H N N 152 
GLN HXT  H N N 153 
GLU N    N N N 154 
GLU CA   C N S 155 
GLU C    C N N 156 
GLU O    O N N 157 
GLU CB   C N N 158 
GLU CG   C N N 159 
GLU CD   C N N 160 
GLU OE1  O N N 161 
GLU OE2  O N N 162 
GLU OXT  O N N 163 
GLU H    H N N 164 
GLU H2   H N N 165 
GLU HA   H N N 166 
GLU HB2  H N N 167 
GLU HB3  H N N 168 
GLU HG2  H N N 169 
GLU HG3  H N N 170 
GLU HE2  H N N 171 
GLU HXT  H N N 172 
GLY N    N N N 173 
GLY CA   C N N 174 
GLY C    C N N 175 
GLY O    O N N 176 
GLY OXT  O N N 177 
GLY H    H N N 178 
GLY H2   H N N 179 
GLY HA2  H N N 180 
GLY HA3  H N N 181 
GLY HXT  H N N 182 
HIS N    N N N 183 
HIS CA   C N S 184 
HIS C    C N N 185 
HIS O    O N N 186 
HIS CB   C N N 187 
HIS CG   C Y N 188 
HIS ND1  N Y N 189 
HIS CD2  C Y N 190 
HIS CE1  C Y N 191 
HIS NE2  N Y N 192 
HIS OXT  O N N 193 
HIS H    H N N 194 
HIS H2   H N N 195 
HIS HA   H N N 196 
HIS HB2  H N N 197 
HIS HB3  H N N 198 
HIS HD1  H N N 199 
HIS HD2  H N N 200 
HIS HE1  H N N 201 
HIS HE2  H N N 202 
HIS HXT  H N N 203 
HOH O    O N N 204 
HOH H1   H N N 205 
HOH H2   H N N 206 
ILE N    N N N 207 
ILE CA   C N S 208 
ILE C    C N N 209 
ILE O    O N N 210 
ILE CB   C N S 211 
ILE CG1  C N N 212 
ILE CG2  C N N 213 
ILE CD1  C N N 214 
ILE OXT  O N N 215 
ILE H    H N N 216 
ILE H2   H N N 217 
ILE HA   H N N 218 
ILE HB   H N N 219 
ILE HG12 H N N 220 
ILE HG13 H N N 221 
ILE HG21 H N N 222 
ILE HG22 H N N 223 
ILE HG23 H N N 224 
ILE HD11 H N N 225 
ILE HD12 H N N 226 
ILE HD13 H N N 227 
ILE HXT  H N N 228 
LEU N    N N N 229 
LEU CA   C N S 230 
LEU C    C N N 231 
LEU O    O N N 232 
LEU CB   C N N 233 
LEU CG   C N N 234 
LEU CD1  C N N 235 
LEU CD2  C N N 236 
LEU OXT  O N N 237 
LEU H    H N N 238 
LEU H2   H N N 239 
LEU HA   H N N 240 
LEU HB2  H N N 241 
LEU HB3  H N N 242 
LEU HG   H N N 243 
LEU HD11 H N N 244 
LEU HD12 H N N 245 
LEU HD13 H N N 246 
LEU HD21 H N N 247 
LEU HD22 H N N 248 
LEU HD23 H N N 249 
LEU HXT  H N N 250 
LYS N    N N N 251 
LYS CA   C N S 252 
LYS C    C N N 253 
LYS O    O N N 254 
LYS CB   C N N 255 
LYS CG   C N N 256 
LYS CD   C N N 257 
LYS CE   C N N 258 
LYS NZ   N N N 259 
LYS OXT  O N N 260 
LYS H    H N N 261 
LYS H2   H N N 262 
LYS HA   H N N 263 
LYS HB2  H N N 264 
LYS HB3  H N N 265 
LYS HG2  H N N 266 
LYS HG3  H N N 267 
LYS HD2  H N N 268 
LYS HD3  H N N 269 
LYS HE2  H N N 270 
LYS HE3  H N N 271 
LYS HZ1  H N N 272 
LYS HZ2  H N N 273 
LYS HZ3  H N N 274 
LYS HXT  H N N 275 
MET N    N N N 276 
MET CA   C N S 277 
MET C    C N N 278 
MET O    O N N 279 
MET CB   C N N 280 
MET CG   C N N 281 
MET SD   S N N 282 
MET CE   C N N 283 
MET OXT  O N N 284 
MET H    H N N 285 
MET H2   H N N 286 
MET HA   H N N 287 
MET HB2  H N N 288 
MET HB3  H N N 289 
MET HG2  H N N 290 
MET HG3  H N N 291 
MET HE1  H N N 292 
MET HE2  H N N 293 
MET HE3  H N N 294 
MET HXT  H N N 295 
PHE N    N N N 296 
PHE CA   C N S 297 
PHE C    C N N 298 
PHE O    O N N 299 
PHE CB   C N N 300 
PHE CG   C Y N 301 
PHE CD1  C Y N 302 
PHE CD2  C Y N 303 
PHE CE1  C Y N 304 
PHE CE2  C Y N 305 
PHE CZ   C Y N 306 
PHE OXT  O N N 307 
PHE H    H N N 308 
PHE H2   H N N 309 
PHE HA   H N N 310 
PHE HB2  H N N 311 
PHE HB3  H N N 312 
PHE HD1  H N N 313 
PHE HD2  H N N 314 
PHE HE1  H N N 315 
PHE HE2  H N N 316 
PHE HZ   H N N 317 
PHE HXT  H N N 318 
PRO N    N N N 319 
PRO CA   C N S 320 
PRO C    C N N 321 
PRO O    O N N 322 
PRO CB   C N N 323 
PRO CG   C N N 324 
PRO CD   C N N 325 
PRO OXT  O N N 326 
PRO H    H N N 327 
PRO HA   H N N 328 
PRO HB2  H N N 329 
PRO HB3  H N N 330 
PRO HG2  H N N 331 
PRO HG3  H N N 332 
PRO HD2  H N N 333 
PRO HD3  H N N 334 
PRO HXT  H N N 335 
SER N    N N N 336 
SER CA   C N S 337 
SER C    C N N 338 
SER O    O N N 339 
SER CB   C N N 340 
SER OG   O N N 341 
SER OXT  O N N 342 
SER H    H N N 343 
SER H2   H N N 344 
SER HA   H N N 345 
SER HB2  H N N 346 
SER HB3  H N N 347 
SER HG   H N N 348 
SER HXT  H N N 349 
THR N    N N N 350 
THR CA   C N S 351 
THR C    C N N 352 
THR O    O N N 353 
THR CB   C N R 354 
THR OG1  O N N 355 
THR CG2  C N N 356 
THR OXT  O N N 357 
THR H    H N N 358 
THR H2   H N N 359 
THR HA   H N N 360 
THR HB   H N N 361 
THR HG1  H N N 362 
THR HG21 H N N 363 
THR HG22 H N N 364 
THR HG23 H N N 365 
THR HXT  H N N 366 
TRP N    N N N 367 
TRP CA   C N S 368 
TRP C    C N N 369 
TRP O    O N N 370 
TRP CB   C N N 371 
TRP CG   C Y N 372 
TRP CD1  C Y N 373 
TRP CD2  C Y N 374 
TRP NE1  N Y N 375 
TRP CE2  C Y N 376 
TRP CE3  C Y N 377 
TRP CZ2  C Y N 378 
TRP CZ3  C Y N 379 
TRP CH2  C Y N 380 
TRP OXT  O N N 381 
TRP H    H N N 382 
TRP H2   H N N 383 
TRP HA   H N N 384 
TRP HB2  H N N 385 
TRP HB3  H N N 386 
TRP HD1  H N N 387 
TRP HE1  H N N 388 
TRP HE3  H N N 389 
TRP HZ2  H N N 390 
TRP HZ3  H N N 391 
TRP HH2  H N N 392 
TRP HXT  H N N 393 
TYR N    N N N 394 
TYR CA   C N S 395 
TYR C    C N N 396 
TYR O    O N N 397 
TYR CB   C N N 398 
TYR CG   C Y N 399 
TYR CD1  C Y N 400 
TYR CD2  C Y N 401 
TYR CE1  C Y N 402 
TYR CE2  C Y N 403 
TYR CZ   C Y N 404 
TYR OH   O N N 405 
TYR OXT  O N N 406 
TYR H    H N N 407 
TYR H2   H N N 408 
TYR HA   H N N 409 
TYR HB2  H N N 410 
TYR HB3  H N N 411 
TYR HD1  H N N 412 
TYR HD2  H N N 413 
TYR HE1  H N N 414 
TYR HE2  H N N 415 
TYR HH   H N N 416 
TYR HXT  H N N 417 
VAL N    N N N 418 
VAL CA   C N S 419 
VAL C    C N N 420 
VAL O    O N N 421 
VAL CB   C N N 422 
VAL CG1  C N N 423 
VAL CG2  C N N 424 
VAL OXT  O N N 425 
VAL H    H N N 426 
VAL H2   H N N 427 
VAL HA   H N N 428 
VAL HB   H N N 429 
VAL HG11 H N N 430 
VAL HG12 H N N 431 
VAL HG13 H N N 432 
VAL HG21 H N N 433 
VAL HG22 H N N 434 
VAL HG23 H N N 435 
VAL HXT  H N N 436 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
B8Z C11 C12  doub Y N 70  
B8Z C11 C09  sing N N 71  
B8Z C11 N24  sing Y N 72  
B8Z C12 S13  sing Y N 73  
B8Z C14 C15  sing N N 74  
B8Z C14 N24  doub Y N 75  
B8Z C14 S13  sing Y N 76  
B8Z C15 O16  sing N N 77  
B8Z C17 C18  doub Y N 78  
B8Z C17 C23  sing Y N 79  
B8Z C17 O16  sing N N 80  
B8Z C18 C19  sing Y N 81  
B8Z C19 C20  doub Y N 82  
B8Z C20 C22  sing Y N 83  
B8Z C20 F21  sing N N 84  
B8Z C22 C23  doub Y N 85  
B8Z C01 O02  sing N N 86  
B8Z C03 C04  doub Y N 87  
B8Z C03 C28  sing Y N 88  
B8Z C03 O02  sing N N 89  
B8Z C04 C05  sing Y N 90  
B8Z C05 C26  doub Y N 91  
B8Z C05 N06  sing Y N 92  
B8Z C07 N06  doub Y N 93  
B8Z C07 N08  sing N N 94  
B8Z C07 S25  sing Y N 95  
B8Z C09 N08  sing N N 96  
B8Z C09 O10  doub N N 97  
B8Z C26 C27  sing Y N 98  
B8Z C26 S25  sing Y N 99  
B8Z C27 C28  doub Y N 100 
B8Z C28 O29  sing N N 101 
B8Z O29 C30  sing N N 102 
B8Z C12 H1   sing N N 103 
B8Z C15 H2   sing N N 104 
B8Z C15 H3   sing N N 105 
B8Z C18 H4   sing N N 106 
B8Z C19 H5   sing N N 107 
B8Z C22 H6   sing N N 108 
B8Z C01 H7   sing N N 109 
B8Z C01 H8   sing N N 110 
B8Z C01 H9   sing N N 111 
B8Z C04 H10  sing N N 112 
B8Z C23 H11  sing N N 113 
B8Z C27 H12  sing N N 114 
B8Z C30 H13  sing N N 115 
B8Z C30 H14  sing N N 116 
B8Z C30 H15  sing N N 117 
B8Z N08 H16  sing N N 118 
CYS N   CA   sing N N 119 
CYS N   H    sing N N 120 
CYS N   H2   sing N N 121 
CYS CA  C    sing N N 122 
CYS CA  CB   sing N N 123 
CYS CA  HA   sing N N 124 
CYS C   O    doub N N 125 
CYS C   OXT  sing N N 126 
CYS CB  SG   sing N N 127 
CYS CB  HB2  sing N N 128 
CYS CB  HB3  sing N N 129 
CYS SG  HG   sing N N 130 
CYS OXT HXT  sing N N 131 
GLN N   CA   sing N N 132 
GLN N   H    sing N N 133 
GLN N   H2   sing N N 134 
GLN CA  C    sing N N 135 
GLN CA  CB   sing N N 136 
GLN CA  HA   sing N N 137 
GLN C   O    doub N N 138 
GLN C   OXT  sing N N 139 
GLN CB  CG   sing N N 140 
GLN CB  HB2  sing N N 141 
GLN CB  HB3  sing N N 142 
GLN CG  CD   sing N N 143 
GLN CG  HG2  sing N N 144 
GLN CG  HG3  sing N N 145 
GLN CD  OE1  doub N N 146 
GLN CD  NE2  sing N N 147 
GLN NE2 HE21 sing N N 148 
GLN NE2 HE22 sing N N 149 
GLN OXT HXT  sing N N 150 
GLU N   CA   sing N N 151 
GLU N   H    sing N N 152 
GLU N   H2   sing N N 153 
GLU CA  C    sing N N 154 
GLU CA  CB   sing N N 155 
GLU CA  HA   sing N N 156 
GLU C   O    doub N N 157 
GLU C   OXT  sing N N 158 
GLU CB  CG   sing N N 159 
GLU CB  HB2  sing N N 160 
GLU CB  HB3  sing N N 161 
GLU CG  CD   sing N N 162 
GLU CG  HG2  sing N N 163 
GLU CG  HG3  sing N N 164 
GLU CD  OE1  doub N N 165 
GLU CD  OE2  sing N N 166 
GLU OE2 HE2  sing N N 167 
GLU OXT HXT  sing N N 168 
GLY N   CA   sing N N 169 
GLY N   H    sing N N 170 
GLY N   H2   sing N N 171 
GLY CA  C    sing N N 172 
GLY CA  HA2  sing N N 173 
GLY CA  HA3  sing N N 174 
GLY C   O    doub N N 175 
GLY C   OXT  sing N N 176 
GLY OXT HXT  sing N N 177 
HIS N   CA   sing N N 178 
HIS N   H    sing N N 179 
HIS N   H2   sing N N 180 
HIS CA  C    sing N N 181 
HIS CA  CB   sing N N 182 
HIS CA  HA   sing N N 183 
HIS C   O    doub N N 184 
HIS C   OXT  sing N N 185 
HIS CB  CG   sing N N 186 
HIS CB  HB2  sing N N 187 
HIS CB  HB3  sing N N 188 
HIS CG  ND1  sing Y N 189 
HIS CG  CD2  doub Y N 190 
HIS ND1 CE1  doub Y N 191 
HIS ND1 HD1  sing N N 192 
HIS CD2 NE2  sing Y N 193 
HIS CD2 HD2  sing N N 194 
HIS CE1 NE2  sing Y N 195 
HIS CE1 HE1  sing N N 196 
HIS NE2 HE2  sing N N 197 
HIS OXT HXT  sing N N 198 
HOH O   H1   sing N N 199 
HOH O   H2   sing N N 200 
ILE N   CA   sing N N 201 
ILE N   H    sing N N 202 
ILE N   H2   sing N N 203 
ILE CA  C    sing N N 204 
ILE CA  CB   sing N N 205 
ILE CA  HA   sing N N 206 
ILE C   O    doub N N 207 
ILE C   OXT  sing N N 208 
ILE CB  CG1  sing N N 209 
ILE CB  CG2  sing N N 210 
ILE CB  HB   sing N N 211 
ILE CG1 CD1  sing N N 212 
ILE CG1 HG12 sing N N 213 
ILE CG1 HG13 sing N N 214 
ILE CG2 HG21 sing N N 215 
ILE CG2 HG22 sing N N 216 
ILE CG2 HG23 sing N N 217 
ILE CD1 HD11 sing N N 218 
ILE CD1 HD12 sing N N 219 
ILE CD1 HD13 sing N N 220 
ILE OXT HXT  sing N N 221 
LEU N   CA   sing N N 222 
LEU N   H    sing N N 223 
LEU N   H2   sing N N 224 
LEU CA  C    sing N N 225 
LEU CA  CB   sing N N 226 
LEU CA  HA   sing N N 227 
LEU C   O    doub N N 228 
LEU C   OXT  sing N N 229 
LEU CB  CG   sing N N 230 
LEU CB  HB2  sing N N 231 
LEU CB  HB3  sing N N 232 
LEU CG  CD1  sing N N 233 
LEU CG  CD2  sing N N 234 
LEU CG  HG   sing N N 235 
LEU CD1 HD11 sing N N 236 
LEU CD1 HD12 sing N N 237 
LEU CD1 HD13 sing N N 238 
LEU CD2 HD21 sing N N 239 
LEU CD2 HD22 sing N N 240 
LEU CD2 HD23 sing N N 241 
LEU OXT HXT  sing N N 242 
LYS N   CA   sing N N 243 
LYS N   H    sing N N 244 
LYS N   H2   sing N N 245 
LYS CA  C    sing N N 246 
LYS CA  CB   sing N N 247 
LYS CA  HA   sing N N 248 
LYS C   O    doub N N 249 
LYS C   OXT  sing N N 250 
LYS CB  CG   sing N N 251 
LYS CB  HB2  sing N N 252 
LYS CB  HB3  sing N N 253 
LYS CG  CD   sing N N 254 
LYS CG  HG2  sing N N 255 
LYS CG  HG3  sing N N 256 
LYS CD  CE   sing N N 257 
LYS CD  HD2  sing N N 258 
LYS CD  HD3  sing N N 259 
LYS CE  NZ   sing N N 260 
LYS CE  HE2  sing N N 261 
LYS CE  HE3  sing N N 262 
LYS NZ  HZ1  sing N N 263 
LYS NZ  HZ2  sing N N 264 
LYS NZ  HZ3  sing N N 265 
LYS OXT HXT  sing N N 266 
MET N   CA   sing N N 267 
MET N   H    sing N N 268 
MET N   H2   sing N N 269 
MET CA  C    sing N N 270 
MET CA  CB   sing N N 271 
MET CA  HA   sing N N 272 
MET C   O    doub N N 273 
MET C   OXT  sing N N 274 
MET CB  CG   sing N N 275 
MET CB  HB2  sing N N 276 
MET CB  HB3  sing N N 277 
MET CG  SD   sing N N 278 
MET CG  HG2  sing N N 279 
MET CG  HG3  sing N N 280 
MET SD  CE   sing N N 281 
MET CE  HE1  sing N N 282 
MET CE  HE2  sing N N 283 
MET CE  HE3  sing N N 284 
MET OXT HXT  sing N N 285 
PHE N   CA   sing N N 286 
PHE N   H    sing N N 287 
PHE N   H2   sing N N 288 
PHE CA  C    sing N N 289 
PHE CA  CB   sing N N 290 
PHE CA  HA   sing N N 291 
PHE C   O    doub N N 292 
PHE C   OXT  sing N N 293 
PHE CB  CG   sing N N 294 
PHE CB  HB2  sing N N 295 
PHE CB  HB3  sing N N 296 
PHE CG  CD1  doub Y N 297 
PHE CG  CD2  sing Y N 298 
PHE CD1 CE1  sing Y N 299 
PHE CD1 HD1  sing N N 300 
PHE CD2 CE2  doub Y N 301 
PHE CD2 HD2  sing N N 302 
PHE CE1 CZ   doub Y N 303 
PHE CE1 HE1  sing N N 304 
PHE CE2 CZ   sing Y N 305 
PHE CE2 HE2  sing N N 306 
PHE CZ  HZ   sing N N 307 
PHE OXT HXT  sing N N 308 
PRO N   CA   sing N N 309 
PRO N   CD   sing N N 310 
PRO N   H    sing N N 311 
PRO CA  C    sing N N 312 
PRO CA  CB   sing N N 313 
PRO CA  HA   sing N N 314 
PRO C   O    doub N N 315 
PRO C   OXT  sing N N 316 
PRO CB  CG   sing N N 317 
PRO CB  HB2  sing N N 318 
PRO CB  HB3  sing N N 319 
PRO CG  CD   sing N N 320 
PRO CG  HG2  sing N N 321 
PRO CG  HG3  sing N N 322 
PRO CD  HD2  sing N N 323 
PRO CD  HD3  sing N N 324 
PRO OXT HXT  sing N N 325 
SER N   CA   sing N N 326 
SER N   H    sing N N 327 
SER N   H2   sing N N 328 
SER CA  C    sing N N 329 
SER CA  CB   sing N N 330 
SER CA  HA   sing N N 331 
SER C   O    doub N N 332 
SER C   OXT  sing N N 333 
SER CB  OG   sing N N 334 
SER CB  HB2  sing N N 335 
SER CB  HB3  sing N N 336 
SER OG  HG   sing N N 337 
SER OXT HXT  sing N N 338 
THR N   CA   sing N N 339 
THR N   H    sing N N 340 
THR N   H2   sing N N 341 
THR CA  C    sing N N 342 
THR CA  CB   sing N N 343 
THR CA  HA   sing N N 344 
THR C   O    doub N N 345 
THR C   OXT  sing N N 346 
THR CB  OG1  sing N N 347 
THR CB  CG2  sing N N 348 
THR CB  HB   sing N N 349 
THR OG1 HG1  sing N N 350 
THR CG2 HG21 sing N N 351 
THR CG2 HG22 sing N N 352 
THR CG2 HG23 sing N N 353 
THR OXT HXT  sing N N 354 
TRP N   CA   sing N N 355 
TRP N   H    sing N N 356 
TRP N   H2   sing N N 357 
TRP CA  C    sing N N 358 
TRP CA  CB   sing N N 359 
TRP CA  HA   sing N N 360 
TRP C   O    doub N N 361 
TRP C   OXT  sing N N 362 
TRP CB  CG   sing N N 363 
TRP CB  HB2  sing N N 364 
TRP CB  HB3  sing N N 365 
TRP CG  CD1  doub Y N 366 
TRP CG  CD2  sing Y N 367 
TRP CD1 NE1  sing Y N 368 
TRP CD1 HD1  sing N N 369 
TRP CD2 CE2  doub Y N 370 
TRP CD2 CE3  sing Y N 371 
TRP NE1 CE2  sing Y N 372 
TRP NE1 HE1  sing N N 373 
TRP CE2 CZ2  sing Y N 374 
TRP CE3 CZ3  doub Y N 375 
TRP CE3 HE3  sing N N 376 
TRP CZ2 CH2  doub Y N 377 
TRP CZ2 HZ2  sing N N 378 
TRP CZ3 CH2  sing Y N 379 
TRP CZ3 HZ3  sing N N 380 
TRP CH2 HH2  sing N N 381 
TRP OXT HXT  sing N N 382 
TYR N   CA   sing N N 383 
TYR N   H    sing N N 384 
TYR N   H2   sing N N 385 
TYR CA  C    sing N N 386 
TYR CA  CB   sing N N 387 
TYR CA  HA   sing N N 388 
TYR C   O    doub N N 389 
TYR C   OXT  sing N N 390 
TYR CB  CG   sing N N 391 
TYR CB  HB2  sing N N 392 
TYR CB  HB3  sing N N 393 
TYR CG  CD1  doub Y N 394 
TYR CG  CD2  sing Y N 395 
TYR CD1 CE1  sing Y N 396 
TYR CD1 HD1  sing N N 397 
TYR CD2 CE2  doub Y N 398 
TYR CD2 HD2  sing N N 399 
TYR CE1 CZ   doub Y N 400 
TYR CE1 HE1  sing N N 401 
TYR CE2 CZ   sing Y N 402 
TYR CE2 HE2  sing N N 403 
TYR CZ  OH   sing N N 404 
TYR OH  HH   sing N N 405 
TYR OXT HXT  sing N N 406 
VAL N   CA   sing N N 407 
VAL N   H    sing N N 408 
VAL N   H2   sing N N 409 
VAL CA  C    sing N N 410 
VAL CA  CB   sing N N 411 
VAL CA  HA   sing N N 412 
VAL C   O    doub N N 413 
VAL C   OXT  sing N N 414 
VAL CB  CG1  sing N N 415 
VAL CB  CG2  sing N N 416 
VAL CB  HB   sing N N 417 
VAL CG1 HG11 sing N N 418 
VAL CG1 HG12 sing N N 419 
VAL CG1 HG13 sing N N 420 
VAL CG2 HG21 sing N N 421 
VAL CG2 HG22 sing N N 422 
VAL CG2 HG23 sing N N 423 
VAL OXT HXT  sing N N 424 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2qd9 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8X3M 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022043 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011696 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007957 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   A GLU A 1 9   ? 27.50205  39.97483 38.72418 0.500 78.08109  ? 4   GLU A N   1 
ATOM   2    N N   B GLU A 1 9   ? 26.26702  40.84901 36.95619 0.500 82.47063  ? 4   GLU A N   1 
ATOM   3    C CA  A GLU A 1 9   ? 26.36198  40.71353 38.18816 0.500 80.34637  ? 4   GLU A CA  1 
ATOM   4    C CA  B GLU A 1 9   ? 26.35378  41.03150 38.40315 0.500 79.15302  ? 4   GLU A CA  1 
ATOM   5    C C   A GLU A 1 9   ? 25.07285  40.35500 38.92106 0.500 71.80905  ? 4   GLU A C   1 
ATOM   6    C C   B GLU A 1 9   ? 25.07026  40.55225 39.07937 0.500 71.53324  ? 4   GLU A C   1 
ATOM   7    O O   A GLU A 1 9   ? 23.98224  40.74838 38.51124 0.500 72.32311  ? 4   GLU A O   1 
ATOM   8    O O   B GLU A 1 9   ? 23.98010  41.02179 38.76084 0.500 72.53661  ? 4   GLU A O   1 
ATOM   9    C CB  A GLU A 1 9   ? 26.19647  40.43669 36.69031 0.500 81.43305  ? 4   GLU A CB  1 
ATOM   10   C CB  B GLU A 1 9   ? 26.62569  42.49776 38.74220 0.500 70.54066  ? 4   GLU A CB  1 
ATOM   11   C CG  A GLU A 1 9   ? 26.99240  41.36496 35.79769 0.500 82.10787  ? 4   GLU A CG  1 
ATOM   12   C CG  B GLU A 1 9   ? 27.81144  42.69549 39.66899 0.500 73.73710  ? 4   GLU A CG  1 
ATOM   13   C CD  A GLU A 1 9   ? 26.10940  42.37080 35.08673 0.500 81.75792  ? 4   GLU A CD  1 
ATOM   14   C CD  B GLU A 1 9   ? 27.41860  42.67866 41.12876 0.500 79.84651  ? 4   GLU A CD  1 
ATOM   15   O OE1 A GLU A 1 9   ? 24.96094  42.01711 34.74656 0.500 83.10000  ? 4   GLU A OE1 1 
ATOM   16   O OE1 B GLU A 1 9   ? 26.30292  42.20658 41.44039 0.500 74.64412  ? 4   GLU A OE1 1 
ATOM   17   O OE2 A GLU A 1 9   ? 26.56313  43.51613 34.87323 0.500 83.18840  ? 4   GLU A OE2 1 
ATOM   18   O OE2 B GLU A 1 9   ? 28.23126  43.12644 41.96744 0.500 79.32112  ? 4   GLU A OE2 1 
ATOM   19   N N   . ARG A 1 10  ? 25.21264  39.60909 40.00297 1.000 72.23060  ? 5   ARG A N   1 
ATOM   20   C CA  . ARG A 1 10  ? 24.05596  39.01749 40.65722 1.000 63.13509  ? 5   ARG A CA  1 
ATOM   21   C C   . ARG A 1 10  ? 23.20869  40.06712 41.36710 1.000 61.21740  ? 5   ARG A C   1 
ATOM   22   O O   . ARG A 1 10  ? 23.73411  40.82873 42.18726 1.000 54.61261  ? 5   ARG A O   1 
ATOM   23   C CB  . ARG A 1 10  ? 24.52268  37.95371 41.64574 1.000 65.64747  ? 5   ARG A CB  1 
ATOM   24   C CG  . ARG A 1 10  ? 23.46825  36.94497 42.05347 1.000 62.49671  ? 5   ARG A CG  1 
ATOM   25   C CD  . ARG A 1 10  ? 24.09644  35.82686 42.85757 1.000 53.83138  ? 5   ARG A CD  1 
ATOM   26   N NE  . ARG A 1 10  ? 23.11776  34.95251 43.49131 1.000 49.59998  ? 5   ARG A NE  1 
ATOM   27   C CZ  . ARG A 1 10  ? 22.55964  35.19762 44.67127 1.000 60.33906  ? 5   ARG A CZ  1 
ATOM   28   N NH1 . ARG A 1 10  ? 22.81360  36.31559 45.33989 1.000 67.87186  ? 5   ARG A NH1 1 
ATOM   29   N NH2 . ARG A 1 10  ? 21.74623  34.29025 45.20729 1.000 47.25346  ? 5   ARG A NH2 1 
ATOM   30   N N   . PRO A 1 11  ? 21.90466  40.12904 41.09905 1.000 54.31024  ? 6   PRO A N   1 
ATOM   31   C CA  . PRO A 1 11  ? 21.02509  40.94263 41.93837 1.000 49.48374  ? 6   PRO A CA  1 
ATOM   32   C C   . PRO A 1 11  ? 20.85430  40.29570 43.29970 1.000 55.74886  ? 6   PRO A C   1 
ATOM   33   O O   . PRO A 1 11  ? 21.24776  39.14584 43.53798 1.000 44.48039  ? 6   PRO A O   1 
ATOM   34   C CB  . PRO A 1 11  ? 19.71198  40.95955 41.15287 1.000 52.00282  ? 6   PRO A CB  1 
ATOM   35   C CG  . PRO A 1 11  ? 19.66222  39.57759 40.55216 1.000 47.27993  ? 6   PRO A CG  1 
ATOM   36   C CD  . PRO A 1 11  ? 21.12775  39.35451 40.10694 1.000 55.30815  ? 6   PRO A CD  1 
ATOM   37   N N   . THR A 1 12  ? 20.24548  41.06439 44.20086 1.000 45.87528  ? 7   THR A N   1 
ATOM   38   C CA  . THR A 1 12  ? 19.90848  40.56131 45.51769 1.000 50.71135  ? 7   THR A CA  1 
ATOM   39   C C   . THR A 1 12  ? 18.58530  39.81719 45.43527 1.000 46.21193  ? 7   THR A C   1 
ATOM   40   O O   . THR A 1 12  ? 17.62406  40.31021 44.84637 1.000 47.93752  ? 7   THR A O   1 
ATOM   41   C CB  . THR A 1 12  ? 19.82213  41.71190 46.52598 1.000 51.92812  ? 7   THR A CB  1 
ATOM   42   O OG1 . THR A 1 12  ? 21.11081  42.32825 46.63181 1.000 44.57296  ? 7   THR A OG1 1 
ATOM   43   C CG2 . THR A 1 12  ? 19.40763  41.17816 47.89391 1.000 53.53179  ? 7   THR A CG2 1 
ATOM   44   N N   . PHE A 1 13  ? 18.53286  38.64348 46.04144 1.000 41.59025  ? 8   PHE A N   1 
ATOM   45   C CA  . PHE A 1 13  ? 17.31848  37.86109 46.15734 1.000 43.89856  ? 8   PHE A CA  1 
ATOM   46   C C   . PHE A 1 13  ? 16.70806  38.05717 47.53381 1.000 47.45549  ? 8   PHE A C   1 
ATOM   47   O O   . PHE A 1 13  ? 17.37823  38.45091 48.48727 1.000 49.47255  ? 8   PHE A O   1 
ATOM   48   C CB  . PHE A 1 13  ? 17.64376  36.39273 45.94559 1.000 43.11888  ? 8   PHE A CB  1 
ATOM   49   C CG  . PHE A 1 13  ? 17.99223  36.07096 44.53046 1.000 43.83351  ? 8   PHE A CG  1 
ATOM   50   C CD1 . PHE A 1 13  ? 19.16596  36.55801 43.96903 1.000 47.39227  ? 8   PHE A CD1 1 
ATOM   51   C CD2 . PHE A 1 13  ? 17.16132  35.27234 43.76290 1.000 40.78321  ? 8   PHE A CD2 1 
ATOM   52   C CE1 . PHE A 1 13  ? 19.49986  36.26305 42.65125 1.000 52.41470  ? 8   PHE A CE1 1 
ATOM   53   C CE2 . PHE A 1 13  ? 17.48278  34.97880 42.44733 1.000 42.49508  ? 8   PHE A CE2 1 
ATOM   54   C CZ  . PHE A 1 13  ? 18.65756  35.47066 41.89573 1.000 45.05998  ? 8   PHE A CZ  1 
ATOM   55   N N   . TYR A 1 14  ? 15.43052  37.74954 47.63038 1.000 38.43224  ? 9   TYR A N   1 
ATOM   56   C CA  . TYR A 1 14  ? 14.72580  37.68348 48.90322 1.000 53.51070  ? 9   TYR A CA  1 
ATOM   57   C C   . TYR A 1 14  ? 13.78818  36.48190 48.88176 1.000 56.59560  ? 9   TYR A C   1 
ATOM   58   O O   . TYR A 1 14  ? 13.42395  35.98351 47.81707 1.000 45.12496  ? 9   TYR A O   1 
ATOM   59   C CB  . TYR A 1 14  ? 13.96906  39.00195 49.18455 1.000 42.44559  ? 9   TYR A CB  1 
ATOM   60   C CG  . TYR A 1 14  ? 12.70303  39.23170 48.36785 1.000 47.38751  ? 9   TYR A CG  1 
ATOM   61   C CD1 . TYR A 1 14  ? 12.76561  39.72899 47.07333 1.000 41.52009  ? 9   TYR A CD1 1 
ATOM   62   C CD2 . TYR A 1 14  ? 11.44904  39.00827 48.91369 1.000 45.55257  ? 9   TYR A CD2 1 
ATOM   63   C CE1 . TYR A 1 14  ? 11.60395  39.94539 46.33350 1.000 46.07546  ? 9   TYR A CE1 1 
ATOM   64   C CE2 . TYR A 1 14  ? 10.29360  39.23562 48.19084 1.000 47.28760  ? 9   TYR A CE2 1 
ATOM   65   C CZ  . TYR A 1 14  ? 10.37873  39.70150 46.90519 1.000 44.87725  ? 9   TYR A CZ  1 
ATOM   66   O OH  . TYR A 1 14  ? 9.22121   39.91563 46.20301 1.000 45.12123  ? 9   TYR A OH  1 
ATOM   67   N N   . ARG A 1 15  ? 13.40194  36.01448 50.06972 1.000 53.54798  ? 10  ARG A N   1 
ATOM   68   C CA  . ARG A 1 15  ? 12.67047  34.76549 50.24490 1.000 53.42981  ? 10  ARG A CA  1 
ATOM   69   C C   . ARG A 1 15  ? 11.24791  35.00778 50.72551 1.000 56.56999  ? 10  ARG A C   1 
ATOM   70   O O   . ARG A 1 15  ? 10.95097  36.00113 51.38993 1.000 66.39455  ? 10  ARG A O   1 
ATOM   71   C CB  . ARG A 1 15  ? 13.36442  33.85241 51.25421 1.000 57.05624  ? 10  ARG A CB  1 
ATOM   72   C CG  . ARG A 1 15  ? 14.87492  33.80055 51.14861 1.000 69.64528  ? 10  ARG A CG  1 
ATOM   73   C CD  . ARG A 1 15  ? 15.37483  32.76736 52.13411 1.000 75.05633  ? 10  ARG A CD  1 
ATOM   74   N NE  . ARG A 1 15  ? 15.48102  31.45847 51.51321 1.000 68.79505  ? 10  ARG A NE  1 
ATOM   75   C CZ  . ARG A 1 15  ? 15.31479  30.31255 52.15725 1.000 80.55940  ? 10  ARG A CZ  1 
ATOM   76   N NH1 . ARG A 1 15  ? 14.99627  30.28117 53.44175 1.000 90.79253  ? 10  ARG A NH1 1 
ATOM   77   N NH2 . ARG A 1 15  ? 15.44501  29.16872 51.49010 1.000 83.01163  ? 10  ARG A NH2 1 
ATOM   78   N N   . GLN A 1 16  ? 10.38417  34.04214 50.42945 1.000 63.41618  ? 11  GLN A N   1 
ATOM   79   C CA  . GLN A 1 16  ? 8.95456   34.17248 50.67338 1.000 68.69848  ? 11  GLN A CA  1 
ATOM   80   C C   . GLN A 1 16  ? 8.34440   32.78636 50.59573 1.000 66.12335  ? 11  GLN A C   1 
ATOM   81   O O   . GLN A 1 16  ? 8.65296   32.03653 49.66258 1.000 65.26873  ? 11  GLN A O   1 
ATOM   82   C CB  . GLN A 1 16  ? 8.32764   35.11831 49.64078 1.000 58.80018  ? 11  GLN A CB  1 
ATOM   83   C CG  . GLN A 1 16  ? 7.08770   35.82139 50.07841 1.000 70.09669  ? 11  GLN A CG  1 
ATOM   84   C CD  . GLN A 1 16  ? 6.53111   36.69886 48.99105 1.000 70.10912  ? 11  GLN A CD  1 
ATOM   85   O OE1 . GLN A 1 16  ? 7.27994   37.20072 48.14822 1.000 72.04225  ? 11  GLN A OE1 1 
ATOM   86   N NE2 . GLN A 1 16  ? 5.21371   36.88003 48.98556 1.000 63.00038  ? 11  GLN A NE2 1 
ATOM   87   N N   . GLU A 1 17  ? 7.47098   32.45777 51.55379 1.000 69.43552  ? 12  GLU A N   1 
ATOM   88   C CA  . GLU A 1 17  ? 6.95044   31.09635 51.65113 1.000 68.08502  ? 12  GLU A CA  1 
ATOM   89   C C   . GLU A 1 17  ? 5.91083   30.80870 50.57046 1.000 79.19690  ? 12  GLU A C   1 
ATOM   90   O O   . GLU A 1 17  ? 5.82669   29.68039 50.07176 1.000 91.03364  ? 12  GLU A O   1 
ATOM   91   C CB  . GLU A 1 17  ? 6.39900   30.86566 53.06261 1.000 70.81609  ? 12  GLU A CB  1 
ATOM   92   C CG  . GLU A 1 17  ? 6.37623   29.40306 53.54307 1.000 89.28029  ? 12  GLU A CG  1 
ATOM   93   C CD  . GLU A 1 17  ? 5.39032   28.51874 52.80780 1.000 98.33603  ? 12  GLU A CD  1 
ATOM   94   O OE1 . GLU A 1 17  ? 4.49157   29.07745 52.14445 1.000 95.18522  ? 12  GLU A OE1 1 
ATOM   95   O OE2 . GLU A 1 17  ? 5.51372   27.27238 52.89268 1.000 94.71720  ? 12  GLU A OE2 1 
ATOM   96   N N   A LEU A 1 18  ? 5.09949   31.78338 50.19156 0.600 74.11782  ? 13  LEU A N   1 
ATOM   97   N N   B LEU A 1 18  ? 5.16551   31.83526 50.17866 0.400 74.23799  ? 13  LEU A N   1 
ATOM   98   C CA  A LEU A 1 18  ? 4.21972   31.59881 49.02402 0.600 79.06959  ? 13  LEU A CA  1 
ATOM   99   C CA  B LEU A 1 18  ? 3.97437   31.68884 49.36360 0.400 79.34460  ? 13  LEU A CA  1 
ATOM   100  C C   A LEU A 1 18  ? 3.37963   30.31629 49.14577 0.600 86.49587  ? 13  LEU A C   1 
ATOM   101  C C   B LEU A 1 18  ? 3.03036   30.73192 50.07676 0.400 87.03521  ? 13  LEU A C   1 
ATOM   102  O O   A LEU A 1 18  ? 2.97789   29.92832 50.24686 0.600 91.15237  ? 13  LEU A O   1 
ATOM   103  O O   B LEU A 1 18  ? 2.21337   31.17195 50.89261 0.400 88.11108  ? 13  LEU A O   1 
ATOM   104  C CB  A LEU A 1 18  ? 5.05255   31.66847 47.75596 0.600 75.63240  ? 13  LEU A CB  1 
ATOM   105  C CB  B LEU A 1 18  ? 4.33162   31.23533 47.94915 0.400 78.13858  ? 13  LEU A CB  1 
ATOM   106  C CG  A LEU A 1 18  ? 4.77098   32.86607 46.84478 0.600 75.46066  ? 13  LEU A CG  1 
ATOM   107  C CG  B LEU A 1 18  ? 4.51242   32.51145 47.11654 0.400 76.60653  ? 13  LEU A CG  1 
ATOM   108  C CD1 A LEU A 1 18  ? 3.46843   33.55562 47.25421 0.600 71.12808  ? 13  LEU A CD1 1 
ATOM   109  C CD1 B LEU A 1 18  ? 5.51572   32.34241 45.99025 0.400 67.69019  ? 13  LEU A CD1 1 
ATOM   110  C CD2 A LEU A 1 18  ? 5.92417   33.85124 46.82570 0.600 68.00822  ? 13  LEU A CD2 1 
ATOM   111  C CD2 B LEU A 1 18  ? 3.17218   33.02145 46.59809 0.400 72.84339  ? 13  LEU A CD2 1 
ATOM   112  N N   A ASN A 1 19  ? 3.10833   29.65449 48.00831 0.600 83.57973  ? 14  ASN A N   1 
ATOM   113  N N   B ASN A 1 19  ? 3.13843   29.43010 49.81385 0.400 90.00183  ? 14  ASN A N   1 
ATOM   114  C CA  A ASN A 1 19  ? 2.20262   28.50503 47.91927 0.600 87.50515  ? 14  ASN A CA  1 
ATOM   115  C CA  B ASN A 1 19  ? 2.31788   28.47479 50.55237 0.400 87.66939  ? 14  ASN A CA  1 
ATOM   116  C C   A ASN A 1 19  ? 2.42545   27.48710 49.03071 0.600 90.98116  ? 14  ASN A C   1 
ATOM   117  C C   B ASN A 1 19  ? 2.98768   27.11154 50.65599 0.400 87.63522  ? 14  ASN A C   1 
ATOM   118  O O   A ASN A 1 19  ? 1.75336   27.51414 50.06920 0.600 86.24596  ? 14  ASN A O   1 
ATOM   119  O O   B ASN A 1 19  ? 3.24573   26.62037 51.75926 0.400 88.57744  ? 14  ASN A O   1 
ATOM   120  C CB  A ASN A 1 19  ? 2.35775   27.80199 46.56508 0.600 78.84785  ? 14  ASN A CB  1 
ATOM   121  C CB  B ASN A 1 19  ? 0.93662   28.33837 49.90854 0.400 86.53308  ? 14  ASN A CB  1 
ATOM   122  C CG  A ASN A 1 19  ? 1.44621   28.37251 45.50242 0.600 78.66065  ? 14  ASN A CG  1 
ATOM   123  C CG  B ASN A 1 19  ? 0.23297   29.67019 49.75969 0.400 86.05471  ? 14  ASN A CG  1 
ATOM   124  O OD1 A ASN A 1 19  ? 0.24812   28.54494 45.72889 0.600 78.84909  ? 14  ASN A OD1 1 
ATOM   125  O OD1 B ASN A 1 19  ? -0.36889  30.17448 50.70762 0.400 90.38314  ? 14  ASN A OD1 1 
ATOM   126  N ND2 A ASN A 1 19  ? 2.00456   28.65728 44.32772 0.600 67.40459  ? 14  ASN A ND2 1 
ATOM   127  N ND2 B ASN A 1 19  ? 0.31295   30.25387 48.56992 0.400 82.45583  ? 14  ASN A ND2 1 
ATOM   128  N N   A LYS A 1 20  ? 3.35086   26.56498 48.79062 0.600 90.11403  ? 15  LYS A N   1 
ATOM   129  N N   B LYS A 1 20  ? 3.27520   26.49646 49.51515 0.400 88.63377  ? 15  LYS A N   1 
ATOM   130  C CA  A LYS A 1 20  ? 3.77279   25.59784 49.78961 0.600 90.48473  ? 15  LYS A CA  1 
ATOM   131  C CA  B LYS A 1 20  ? 3.83114   25.15242 49.49674 0.400 90.64616  ? 15  LYS A CA  1 
ATOM   132  C C   A LYS A 1 20  ? 5.28872   25.45499 49.79960 0.600 89.23723  ? 15  LYS A C   1 
ATOM   133  C C   B LYS A 1 20  ? 5.34743   25.12419 49.43969 0.400 89.86415  ? 15  LYS A C   1 
ATOM   134  O O   A LYS A 1 20  ? 5.82439   24.70983 50.62745 0.600 85.89694  ? 15  LYS A O   1 
ATOM   135  O O   B LYS A 1 20  ? 5.94403   24.13722 49.88556 0.400 88.07837  ? 15  LYS A O   1 
ATOM   136  C CB  A LYS A 1 20  ? 3.09319   24.23841 49.52458 0.600 89.29900  ? 15  LYS A CB  1 
ATOM   137  C CB  B LYS A 1 20  ? 3.26170   24.37827 48.30907 0.400 89.08243  ? 15  LYS A CB  1 
ATOM   138  C CG  A LYS A 1 20  ? 3.58113   23.06805 50.36040 0.600 92.70246  ? 15  LYS A CG  1 
ATOM   139  C CG  B LYS A 1 20  ? 2.88984   25.27998 47.15310 0.400 87.46082  ? 15  LYS A CG  1 
ATOM   140  C CD  A LYS A 1 20  ? 2.40763   22.39400 51.06220 0.600 91.98344  ? 15  LYS A CD  1 
ATOM   141  C CD  B LYS A 1 20  ? 1.39077   25.27225 46.94046 0.400 87.54556  ? 15  LYS A CD  1 
ATOM   142  C CE  A LYS A 1 20  ? 2.76475   20.99732 51.54395 0.600 89.57089  ? 15  LYS A CE  1 
ATOM   143  C CE  B LYS A 1 20  ? 0.63997   25.20055 48.25499 0.400 89.86358  ? 15  LYS A CE  1 
ATOM   144  N NZ  A LYS A 1 20  ? 2.98669   20.06929 50.40179 0.600 92.03332  ? 15  LYS A NZ  1 
ATOM   145  N NZ  B LYS A 1 20  ? 0.10491   23.83527 48.49619 0.400 88.02092  ? 15  LYS A NZ  1 
ATOM   146  N N   . THR A 1 21  ? 5.98820   26.17113 48.92091 1.000 86.18064  ? 16  THR A N   1 
ATOM   147  C CA  . THR A 1 21  ? 7.42898   26.11442 48.75271 1.000 77.49886  ? 16  THR A CA  1 
ATOM   148  C C   . THR A 1 21  ? 8.04950   27.49685 48.92713 1.000 70.27270  ? 16  THR A C   1 
ATOM   149  O O   . THR A 1 21  ? 7.40477   28.52418 48.70829 1.000 69.69424  ? 16  THR A O   1 
ATOM   150  C CB  . THR A 1 21  ? 7.76273   25.52976 47.37153 1.000 82.56635  ? 16  THR A CB  1 
ATOM   151  O OG1 . THR A 1 21  ? 9.05922   24.91834 47.40207 1.000 80.15071  ? 16  THR A OG1 1 
ATOM   152  C CG2 . THR A 1 21  ? 7.68622   26.61001 46.27566 1.000 66.70327  ? 16  THR A CG2 1 
ATOM   153  N N   . ILE A 1 22  ? 9.32079   27.51047 49.30263 1.000 70.15647  ? 17  ILE A N   1 
ATOM   154  C CA  . ILE A 1 22  ? 10.04039  28.76210 49.50287 1.000 58.97177  ? 17  ILE A CA  1 
ATOM   155  C C   . ILE A 1 22  ? 10.48339  29.31234 48.15038 1.000 60.95541  ? 17  ILE A C   1 
ATOM   156  O O   . ILE A 1 22  ? 11.24001  28.66053 47.42567 1.000 62.68417  ? 17  ILE A O   1 
ATOM   157  C CB  . ILE A 1 22  ? 11.24277  28.54938 50.42772 1.000 77.24037  ? 17  ILE A CB  1 
ATOM   158  C CG1 . ILE A 1 22  ? 10.77979  27.96116 51.76922 1.000 61.33844  ? 17  ILE A CG1 1 
ATOM   159  C CG2 . ILE A 1 22  ? 12.00476  29.86283 50.60788 1.000 74.47783  ? 17  ILE A CG2 1 
ATOM   160  C CD1 . ILE A 1 22  ? 9.97158   28.92022 52.60816 1.000 73.58083  ? 17  ILE A CD1 1 
ATOM   161  N N   . TRP A 1 23  ? 10.03049  30.51965 47.82103 1.000 54.51892  ? 18  TRP A N   1 
ATOM   162  C CA  . TRP A 1 23  ? 10.40487  31.21308 46.59091 1.000 49.22794  ? 18  TRP A CA  1 
ATOM   163  C C   . TRP A 1 23  ? 11.51635  32.20647 46.88458 1.000 52.89773  ? 18  TRP A C   1 
ATOM   164  O O   . TRP A 1 23  ? 11.39384  33.01742 47.80243 1.000 55.52729  ? 18  TRP A O   1 
ATOM   165  C CB  . TRP A 1 23  ? 9.21253   31.94992 45.99384 1.000 46.74793  ? 18  TRP A CB  1 
ATOM   166  C CG  . TRP A 1 23  ? 8.24047   31.05044 45.31820 1.000 55.42391  ? 18  TRP A CG  1 
ATOM   167  C CD1 . TRP A 1 23  ? 7.59987   29.97512 45.87029 1.000 63.10347  ? 18  TRP A CD1 1 
ATOM   168  C CD2 . TRP A 1 23  ? 7.73524   31.17672 43.98068 1.000 59.13035  ? 18  TRP A CD2 1 
ATOM   169  N NE1 . TRP A 1 23  ? 6.74941   29.41109 44.95233 1.000 63.46110  ? 18  TRP A NE1 1 
ATOM   170  C CE2 . TRP A 1 23  ? 6.80408   30.13312 43.78742 1.000 58.04677  ? 18  TRP A CE2 1 
ATOM   171  C CE3 . TRP A 1 23  ? 7.98320   32.06549 42.92722 1.000 45.79425  ? 18  TRP A CE3 1 
ATOM   172  C CZ2 . TRP A 1 23  ? 6.11404   29.95188 42.58126 1.000 50.06596  ? 18  TRP A CZ2 1 
ATOM   173  C CZ3 . TRP A 1 23  ? 7.30528   31.87722 41.71891 1.000 44.89433  ? 18  TRP A CZ3 1 
ATOM   174  C CH2 . TRP A 1 23  ? 6.37040   30.82960 41.56529 1.000 45.02020  ? 18  TRP A CH2 1 
ATOM   175  N N   . GLU A 1 24  ? 12.58631  32.15253 46.09911 1.000 45.16928  ? 19  GLU A N   1 
ATOM   176  C CA  . GLU A 1 24  ? 13.72601  33.05108 46.24412 1.000 41.28386  ? 19  GLU A CA  1 
ATOM   177  C C   . GLU A 1 24  ? 13.90635  33.75385 44.90150 1.000 42.43001  ? 19  GLU A C   1 
ATOM   178  O O   . GLU A 1 24  ? 14.25199  33.10637 43.91577 1.000 39.90972  ? 19  GLU A O   1 
ATOM   179  C CB  . GLU A 1 24  ? 14.98747  32.27896 46.66338 1.000 46.77624  ? 19  GLU A CB  1 
ATOM   180  C CG  . GLU A 1 24  ? 16.15336  33.15900 47.15457 1.000 60.51257  ? 19  GLU A CG  1 
ATOM   181  C CD  . GLU A 1 24  ? 17.14203  32.40078 48.04344 1.000 72.99195  ? 19  GLU A CD  1 
ATOM   182  O OE1 . GLU A 1 24  ? 16.89001  31.20884 48.33679 1.000 70.90894  ? 19  GLU A OE1 1 
ATOM   183  O OE2 . GLU A 1 24  ? 18.17150  32.99729 48.44107 1.000 54.45322  ? 19  GLU A OE2 1 
ATOM   184  N N   . VAL A 1 25  ? 13.70258  35.07108 44.85913 1.000 38.22323  ? 20  VAL A N   1 
ATOM   185  C CA  . VAL A 1 25  ? 13.63279  35.79937 43.58525 1.000 37.24827  ? 20  VAL A CA  1 
ATOM   186  C C   . VAL A 1 25  ? 14.31916  37.14068 43.74064 1.000 41.96223  ? 20  VAL A C   1 
ATOM   187  O O   . VAL A 1 25  ? 14.45026  37.67942 44.84672 1.000 42.05836  ? 20  VAL A O   1 
ATOM   188  C CB  . VAL A 1 25  ? 12.17216  36.01780 43.12730 1.000 44.70431  ? 20  VAL A CB  1 
ATOM   189  C CG1 . VAL A 1 25  ? 11.37839  34.70830 43.22609 1.000 35.75739  ? 20  VAL A CG1 1 
ATOM   190  C CG2 . VAL A 1 25  ? 11.49475  37.10318 43.96885 1.000 45.77139  ? 20  VAL A CG2 1 
ATOM   191  N N   . PRO A 1 26  ? 14.80306  37.69240 42.63962 1.000 40.05016  ? 21  PRO A N   1 
ATOM   192  C CA  . PRO A 1 26  ? 15.44396  39.00702 42.70930 1.000 38.35893  ? 21  PRO A CA  1 
ATOM   193  C C   . PRO A 1 26  ? 14.47438  40.09144 43.14315 1.000 45.33262  ? 21  PRO A C   1 
ATOM   194  O O   . PRO A 1 26  ? 13.29446  40.05270 42.81561 1.000 36.46566  ? 21  PRO A O   1 
ATOM   195  C CB  . PRO A 1 26  ? 15.93926  39.24190 41.27958 1.000 41.87977  ? 21  PRO A CB  1 
ATOM   196  C CG  . PRO A 1 26  ? 15.85498  37.91263 40.60018 1.000 44.66259  ? 21  PRO A CG  1 
ATOM   197  C CD  . PRO A 1 26  ? 14.81469  37.11607 41.28546 1.000 41.52548  ? 21  PRO A CD  1 
ATOM   198  N N   . GLU A 1 27  ? 14.98907  41.08935 43.86612 1.000 40.89906  ? 22  GLU A N   1 
ATOM   199  C CA  . GLU A 1 27  ? 14.09623  42.07020 44.49166 1.000 42.14649  ? 22  GLU A CA  1 
ATOM   200  C C   . GLU A 1 27  ? 13.31559  42.88762 43.47347 1.000 38.28945  ? 22  GLU A C   1 
ATOM   201  O O   . GLU A 1 27  ? 12.23449  43.39431 43.79961 1.000 38.77328  ? 22  GLU A O   1 
ATOM   202  C CB  . GLU A 1 27  ? 14.87320  43.01584 45.42489 1.000 39.17841  ? 22  GLU A CB  1 
ATOM   203  C CG  . GLU A 1 27  ? 16.31452  43.21139 45.06689 1.000 58.83937  ? 22  GLU A CG  1 
ATOM   204  C CD  . GLU A 1 27  ? 17.08080  44.03632 46.11039 1.000 50.04976  ? 22  GLU A CD  1 
ATOM   205  O OE1 . GLU A 1 27  ? 16.77052  43.94210 47.32247 1.000 58.33634  ? 22  GLU A OE1 1 
ATOM   206  O OE2 . GLU A 1 27  ? 18.00354  44.77494 45.70484 1.000 54.70958  ? 22  GLU A OE2 1 
ATOM   207  N N   . ARG A 1 28  ? 13.80390  42.97323 42.23771 1.000 37.84035  ? 23  ARG A N   1 
ATOM   208  C CA  . ARG A 1 28  ? 13.04748  43.62283 41.17082 1.000 40.48791  ? 23  ARG A CA  1 
ATOM   209  C C   . ARG A 1 28  ? 11.59643  43.14124 41.05864 1.000 43.30658  ? 23  ARG A C   1 
ATOM   210  O O   . ARG A 1 28  ? 10.70266  43.92739 40.69621 1.000 43.44772  ? 23  ARG A O   1 
ATOM   211  C CB  . ARG A 1 28  ? 13.78934  43.41772 39.86515 1.000 43.61384  ? 23  ARG A CB  1 
ATOM   212  C CG  . ARG A 1 28  ? 13.46430  42.12095 39.18060 1.000 36.00946  ? 23  ARG A CG  1 
ATOM   213  C CD  . ARG A 1 28  ? 14.37807  42.01253 38.01143 1.000 44.70689  ? 23  ARG A CD  1 
ATOM   214  N NE  . ARG A 1 28  ? 13.71831  42.51153 36.81293 1.000 41.13783  ? 23  ARG A NE  1 
ATOM   215  C CZ  . ARG A 1 28  ? 14.22802  42.39228 35.59917 1.000 46.27747  ? 23  ARG A CZ  1 
ATOM   216  N NH1 . ARG A 1 28  ? 15.43183  41.86840 35.41087 1.000 46.05866  ? 23  ARG A NH1 1 
ATOM   217  N NH2 . ARG A 1 28  ? 13.53620  42.84435 34.55890 1.000 48.17952  ? 23  ARG A NH2 1 
ATOM   218  N N   . TYR A 1 29  ? 11.33678  41.87002 41.36614 1.000 34.21034  ? 24  TYR A N   1 
ATOM   219  C CA  . TYR A 1 29  ? 9.98436   41.31207 41.31045 1.000 33.23844  ? 24  TYR A CA  1 
ATOM   220  C C   . TYR A 1 29  ? 9.28768   41.50322 42.64985 1.000 37.78387  ? 24  TYR A C   1 
ATOM   221  O O   . TYR A 1 29  ? 9.74833   40.97234 43.66674 1.000 42.38784  ? 24  TYR A O   1 
ATOM   222  C CB  . TYR A 1 29  ? 10.02394  39.82054 40.96285 1.000 35.72679  ? 24  TYR A CB  1 
ATOM   223  C CG  . TYR A 1 29  ? 10.71086  39.58888 39.61989 1.000 40.37350  ? 24  TYR A CG  1 
ATOM   224  C CD1 . TYR A 1 29  ? 10.10961  40.02837 38.44289 1.000 37.83687  ? 24  TYR A CD1 1 
ATOM   225  C CD2 . TYR A 1 29  ? 11.95882  38.98595 39.53425 1.000 35.53705  ? 24  TYR A CD2 1 
ATOM   226  C CE1 . TYR A 1 29  ? 10.70211  39.86894 37.21987 1.000 37.55794  ? 24  TYR A CE1 1 
ATOM   227  C CE2 . TYR A 1 29  ? 12.58235  38.81690 38.29452 1.000 37.01290  ? 24  TYR A CE2 1 
ATOM   228  C CZ  . TYR A 1 29  ? 11.93646  39.26185 37.14596 1.000 42.11453  ? 24  TYR A CZ  1 
ATOM   229  O OH  . TYR A 1 29  ? 12.51858  39.13203 35.91676 1.000 37.81153  ? 24  TYR A OH  1 
ATOM   230  N N   . GLN A 1 30  ? 8.14285   42.19428 42.63304 1.000 39.96073  ? 25  GLN A N   1 
ATOM   231  C CA  . GLN A 1 30  ? 7.40188   42.55115 43.84510 1.000 41.07787  ? 25  GLN A CA  1 
ATOM   232  C C   . GLN A 1 30  ? 5.94870   42.07747 43.75098 1.000 40.50714  ? 25  GLN A C   1 
ATOM   233  O O   . GLN A 1 30  ? 5.42331   41.78111 42.66032 1.000 43.66565  ? 25  GLN A O   1 
ATOM   234  C CB  . GLN A 1 30  ? 7.45943   44.08234 44.09411 1.000 41.74884  ? 25  GLN A CB  1 
ATOM   235  C CG  . GLN A 1 30  ? 8.86417   44.59203 44.40788 1.000 41.62077  ? 25  GLN A CG  1 
ATOM   236  C CD  . GLN A 1 30  ? 9.33249   44.17333 45.78378 1.000 42.41858  ? 25  GLN A CD  1 
ATOM   237  O OE1 . GLN A 1 30  ? 8.57757   44.26468 46.74350 1.000 46.67456  ? 25  GLN A OE1 1 
ATOM   238  N NE2 . GLN A 1 30  ? 10.54664  43.66014 45.88006 1.000 39.21909  ? 25  GLN A NE2 1 
ATOM   239  N N   A ASN A 1 31  ? 5.30932   41.97573 44.92131 0.500 50.63620  ? 26  ASN A N   1 
ATOM   240  N N   B ASN A 1 31  ? 5.30534   42.00132 44.91993 0.500 50.62172  ? 26  ASN A N   1 
ATOM   241  C CA  A ASN A 1 31  ? 3.88332   41.62852 45.02039 0.500 54.47197  ? 26  ASN A CA  1 
ATOM   242  C CA  B ASN A 1 31  ? 3.88459   41.64262 45.02646 0.500 54.47510  ? 26  ASN A CA  1 
ATOM   243  C C   A ASN A 1 31  ? 3.55859   40.29365 44.35322 0.500 51.46252  ? 26  ASN A C   1 
ATOM   244  C C   B ASN A 1 31  ? 3.57635   40.30062 44.36323 0.500 51.45915  ? 26  ASN A C   1 
ATOM   245  O O   A ASN A 1 31  ? 2.65467   40.20053 43.51873 0.500 55.81306  ? 26  ASN A O   1 
ATOM   246  O O   B ASN A 1 31  ? 2.68678   40.19426 43.51510 0.500 55.82025  ? 26  ASN A O   1 
ATOM   247  C CB  A ASN A 1 31  ? 3.00656   42.74211 44.43829 0.500 53.69614  ? 26  ASN A CB  1 
ATOM   248  C CB  B ASN A 1 31  ? 2.98955   42.74223 44.44608 0.500 53.71175  ? 26  ASN A CB  1 
ATOM   249  C CG  A ASN A 1 31  ? 1.57311   42.69300 44.95322 0.500 68.58456  ? 26  ASN A CG  1 
ATOM   250  C CG  B ASN A 1 31  ? 3.49053   44.13991 44.75594 0.500 68.03231  ? 26  ASN A CG  1 
ATOM   251  O OD1 A ASN A 1 31  ? 1.21915   41.83968 45.76517 0.500 64.44493  ? 26  ASN A OD1 1 
ATOM   252  O OD1 B ASN A 1 31  ? 3.77286   44.46798 45.91114 0.500 64.34231  ? 26  ASN A OD1 1 
ATOM   253  N ND2 A ASN A 1 31  ? 0.73940   43.60798 44.46796 0.500 77.17167  ? 26  ASN A ND2 1 
ATOM   254  N ND2 B ASN A 1 31  ? 3.59296   44.97549 43.72740 0.500 76.97231  ? 26  ASN A ND2 1 
ATOM   255  N N   A LEU A 1 32  ? 4.29703   39.24881 44.72410 0.630 48.03731  ? 27  LEU A N   1 
ATOM   256  N N   B LEU A 1 32  ? 4.31995   39.26615 44.75294 0.370 48.15838  ? 27  LEU A N   1 
ATOM   257  C CA  A LEU A 1 32  ? 3.99034   37.92333 44.19673 0.630 50.01567  ? 27  LEU A CA  1 
ATOM   258  C CA  B LEU A 1 32  ? 4.04023   37.92904 44.24233 0.370 50.04199  ? 27  LEU A CA  1 
ATOM   259  C C   A LEU A 1 32  ? 2.70186   37.39406 44.81805 0.630 53.34487  ? 27  LEU A C   1 
ATOM   260  C C   B LEU A 1 32  ? 2.74906   37.39695 44.85054 0.370 53.40569  ? 27  LEU A C   1 
ATOM   261  O O   A LEU A 1 32  ? 2.54633   37.41336 46.03954 0.630 56.72812  ? 27  LEU A O   1 
ATOM   262  O O   B LEU A 1 32  ? 2.54383   37.48539 46.06338 0.370 56.61902  ? 27  LEU A O   1 
ATOM   263  C CB  A LEU A 1 32  ? 5.12888   36.94488 44.47401 0.630 50.92463  ? 27  LEU A CB  1 
ATOM   264  C CB  B LEU A 1 32  ? 5.18998   36.96972 44.54984 0.370 51.02037  ? 27  LEU A CB  1 
ATOM   265  C CG  A LEU A 1 32  ? 6.36035   36.98790 43.55716 0.630 46.26230  ? 27  LEU A CG  1 
ATOM   266  C CG  B LEU A 1 32  ? 6.63270   37.47513 44.67126 0.370 50.74824  ? 27  LEU A CG  1 
ATOM   267  C CD1 A LEU A 1 32  ? 7.16369   38.24703 43.82918 0.630 43.75300  ? 27  LEU A CD1 1 
ATOM   268  C CD1 B LEU A 1 32  ? 7.59280   36.30266 44.62877 0.370 45.34565  ? 27  LEU A CD1 1 
ATOM   269  C CD2 A LEU A 1 32  ? 7.20623   35.76990 43.75515 0.630 48.34677  ? 27  LEU A CD2 1 
ATOM   270  C CD2 B LEU A 1 32  ? 6.97195   38.46908 43.57554 0.370 44.18664  ? 27  LEU A CD2 1 
ATOM   271  N N   A SER A 1 33  ? 1.78652   36.90282 43.98425 0.630 56.17649  ? 28  SER A N   1 
ATOM   272  N N   B SER A 1 33  ? 1.88376   36.83228 44.00783 0.370 55.91417  ? 28  SER A N   1 
ATOM   273  C CA  A SER A 1 33  ? 0.56258   36.25261 44.45629 0.630 52.21183  ? 28  SER A CA  1 
ATOM   274  C CA  B SER A 1 33  ? 0.63002   36.23924 44.46421 0.370 52.29141  ? 28  SER A CA  1 
ATOM   275  C C   A SER A 1 33  ? 0.34820   34.99248 43.62669 0.630 49.12567  ? 28  SER A C   1 
ATOM   276  C C   B SER A 1 33  ? 0.33218   34.99388 43.63343 0.370 49.29037  ? 28  SER A C   1 
ATOM   277  O O   A SER A 1 33  ? 0.25608   35.07651 42.38301 0.630 51.69132  ? 28  SER A O   1 
ATOM   278  O O   B SER A 1 33  ? 0.20130   35.08345 42.40540 0.370 51.85647  ? 28  SER A O   1 
ATOM   279  C CB  A SER A 1 33  ? -0.66308  37.17836 44.37139 0.630 55.97874  ? 28  SER A CB  1 
ATOM   280  C CB  B SER A 1 33  ? -0.51352  37.25798 44.37205 0.370 55.86650  ? 28  SER A CB  1 
ATOM   281  O OG  A SER A 1 33  ? -0.60688  38.01565 43.23643 0.630 51.58996  ? 28  SER A OG  1 
ATOM   282  O OG  B SER A 1 33  ? -1.72315  36.67289 43.92379 0.370 52.79863  ? 28  SER A OG  1 
ATOM   283  N N   . PRO A 1 34  ? 0.22742   33.82061 44.25359 1.000 53.31151  ? 29  PRO A N   1 
ATOM   284  C CA  . PRO A 1 34  ? 0.07757   32.58913 43.47031 1.000 55.35932  ? 29  PRO A CA  1 
ATOM   285  C C   . PRO A 1 34  ? -1.15590  32.61652 42.58851 1.000 60.33990  ? 29  PRO A C   1 
ATOM   286  O O   . PRO A 1 34  ? -2.21210  33.11115 42.97821 1.000 67.87413  ? 29  PRO A O   1 
ATOM   287  C CB  . PRO A 1 34  ? 0.00764   31.49011 44.53709 1.000 67.62479  ? 29  PRO A CB  1 
ATOM   288  C CG  . PRO A 1 34  ? -0.41898  32.15927 45.77292 1.000 62.39648  ? 29  PRO A CG  1 
ATOM   289  C CD  . PRO A 1 34  ? 0.04973   33.58792 45.69774 1.000 62.65135  ? 29  PRO A CD  1 
ATOM   290  N N   A VAL A 1 35  ? -1.02431  32.05453 41.38789 0.580 60.52051  ? 30  VAL A N   1 
ATOM   291  N N   B VAL A 1 35  ? -0.98298  32.10005 41.37353 0.420 60.55312  ? 30  VAL A N   1 
ATOM   292  C CA  A VAL A 1 35  ? -2.12984  32.06640 40.43866 0.580 63.17132  ? 30  VAL A CA  1 
ATOM   293  C CA  B VAL A 1 35  ? -2.01959  32.11472 40.35188 0.420 63.11030  ? 30  VAL A CA  1 
ATOM   294  C C   A VAL A 1 35  ? -2.50090  30.64706 40.03731 0.580 65.74275  ? 30  VAL A C   1 
ATOM   295  C C   B VAL A 1 35  ? -2.38809  30.71907 39.87279 0.420 65.48557  ? 30  VAL A C   1 
ATOM   296  O O   A VAL A 1 35  ? -3.64568  30.38483 39.65059 0.580 74.70190  ? 30  VAL A O   1 
ATOM   297  O O   B VAL A 1 35  ? -3.45880  30.54988 39.26508 0.420 72.16320  ? 30  VAL A O   1 
ATOM   298  C CB  A VAL A 1 35  ? -1.79324  32.91143 39.19887 0.580 63.64768  ? 30  VAL A CB  1 
ATOM   299  C CB  B VAL A 1 35  ? -1.58677  32.98991 39.15533 0.420 63.34561  ? 30  VAL A CB  1 
ATOM   300  C CG1 A VAL A 1 35  ? -1.20283  34.24531 39.61627 0.580 64.21374  ? 30  VAL A CG1 1 
ATOM   301  C CG1 B VAL A 1 35  ? -1.74948  32.23744 37.84306 0.420 64.30477  ? 30  VAL A CG1 1 
ATOM   302  C CG2 A VAL A 1 35  ? -0.85262  32.15880 38.27636 0.580 61.28177  ? 30  VAL A CG2 1 
ATOM   303  C CG2 B VAL A 1 35  ? -2.36275  34.29957 39.13517 0.420 65.90951  ? 30  VAL A CG2 1 
ATOM   304  N N   . GLY A 1 36  ? -1.55134  29.72317 40.12252 1.000 64.12506  ? 31  GLY A N   1 
ATOM   305  C CA  . GLY A 1 36  ? -1.83672  28.35506 39.73266 1.000 70.51077  ? 31  GLY A CA  1 
ATOM   306  C C   . GLY A 1 36  ? -0.68705  27.45711 40.12835 1.000 78.99325  ? 31  GLY A C   1 
ATOM   307  O O   . GLY A 1 36  ? 0.44527   27.91360 40.32023 1.000 70.48323  ? 31  GLY A O   1 
ATOM   308  N N   . SER A 1 37  ? -1.00096  26.17231 40.26245 1.000 77.24554  ? 32  SER A N   1 
ATOM   309  C CA  . SER A 1 37  ? 0.00065   25.15775 40.57371 1.000 81.63010  ? 32  SER A CA  1 
ATOM   310  C C   . SER A 1 37  ? -0.18204  24.00627 39.58461 1.000 92.22804  ? 32  SER A C   1 
ATOM   311  O O   . SER A 1 37  ? -0.81768  24.14364 38.53163 1.000 93.66976  ? 32  SER A O   1 
ATOM   312  C CB  . SER A 1 37  ? -0.11539  24.72542 42.03981 1.000 88.40262  ? 32  SER A CB  1 
ATOM   313  O OG  . SER A 1 37  ? 0.23491   23.36429 42.20794 1.000 99.38646  ? 32  SER A OG  1 
ATOM   314  N N   . GLY A 1 38  ? 0.38744   22.85432 39.89948 1.000 97.09462  ? 33  GLY A N   1 
ATOM   315  C CA  . GLY A 1 38  ? 0.18968   21.67681 39.06981 1.000 93.82817  ? 33  GLY A CA  1 
ATOM   316  C C   . GLY A 1 38  ? 1.35490   20.71031 39.20562 1.000 86.19751  ? 33  GLY A C   1 
ATOM   317  O O   . GLY A 1 38  ? 2.01527   20.65818 40.24064 1.000 85.96097  ? 33  GLY A O   1 
ATOM   318  N N   A ALA A 1 39  ? 1.56371   19.93555 38.15173 0.500 87.79936  ? 34  ALA A N   1 
ATOM   319  N N   B ALA A 1 39  ? 1.57948   19.94591 38.12931 0.500 87.80028  ? 34  ALA A N   1 
ATOM   320  C CA  A ALA A 1 39  ? 2.68649   19.01062 38.10032 0.500 86.30386  ? 34  ALA A CA  1 
ATOM   321  C CA  B ALA A 1 39  ? 2.67163   18.98312 38.07815 0.500 86.29364  ? 34  ALA A CA  1 
ATOM   322  C C   A ALA A 1 39  ? 3.97371   19.66996 37.64760 0.500 82.27371  ? 34  ALA A C   1 
ATOM   323  C C   B ALA A 1 39  ? 3.96620   19.58249 37.54913 0.500 82.29662  ? 34  ALA A C   1 
ATOM   324  O O   A ALA A 1 39  ? 5.04555   19.30731 38.14397 0.500 84.22502  ? 34  ALA A O   1 
ATOM   325  O O   B ALA A 1 39  ? 5.04516   19.05951 37.85393 0.500 84.92370  ? 34  ALA A O   1 
ATOM   326  C CB  A ALA A 1 39  ? 2.36528   17.84833 37.16657 0.500 79.96856  ? 34  ALA A CB  1 
ATOM   327  C CB  B ALA A 1 39  ? 2.28028   17.78656 37.20894 0.500 79.95822  ? 34  ALA A CB  1 
ATOM   328  N N   . TYR A 1 40  ? 3.87614   20.65006 36.74751 1.000 79.09792  ? 35  TYR A N   1 
ATOM   329  C CA  . TYR A 1 40  ? 5.05162   21.35208 36.24301 1.000 83.54349  ? 35  TYR A CA  1 
ATOM   330  C C   . TYR A 1 40  ? 5.73560   22.19722 37.31232 1.000 76.93524  ? 35  TYR A C   1 
ATOM   331  O O   . TYR A 1 40  ? 6.94424   22.44371 37.21813 1.000 73.80048  ? 35  TYR A O   1 
ATOM   332  C CB  . TYR A 1 40  ? 4.61887   22.22533 35.06023 1.000 91.60075  ? 35  TYR A CB  1 
ATOM   333  C CG  . TYR A 1 40  ? 3.50987   23.19574 35.44755 1.000 82.85094  ? 35  TYR A CG  1 
ATOM   334  C CD1 . TYR A 1 40  ? 3.79514   24.42730 36.03007 1.000 84.43212  ? 35  TYR A CD1 1 
ATOM   335  C CD2 . TYR A 1 40  ? 2.16911   22.85378 35.26845 1.000 88.22507  ? 35  TYR A CD2 1 
ATOM   336  C CE1 . TYR A 1 40  ? 2.77667   25.30757 36.40055 1.000 84.84964  ? 35  TYR A CE1 1 
ATOM   337  C CE2 . TYR A 1 40  ? 1.14619   23.72505 35.63413 1.000 94.69355  ? 35  TYR A CE2 1 
ATOM   338  C CZ  . TYR A 1 40  ? 1.45561   24.95168 36.20029 1.000 96.03738  ? 35  TYR A CZ  1 
ATOM   339  O OH  . TYR A 1 40  ? 0.45677   25.83068 36.57577 1.000 85.84314  ? 35  TYR A OH  1 
ATOM   340  N N   A GLY A 1 41  ? 4.99163   22.61085 38.33278 0.500 76.39275  ? 36  GLY A N   1 
ATOM   341  N N   B GLY A 1 41  ? 4.99359   22.65576 38.32461 0.500 76.39579  ? 36  GLY A N   1 
ATOM   342  C CA  A GLY A 1 41  ? 5.48721   23.52799 39.33081 0.500 72.94077  ? 36  GLY A CA  1 
ATOM   343  C CA  B GLY A 1 41  ? 5.54189   23.50836 39.36674 0.500 72.93993  ? 36  GLY A CA  1 
ATOM   344  C C   A GLY A 1 41  ? 4.39103   24.48793 39.73554 0.500 72.59401  ? 36  GLY A C   1 
ATOM   345  C C   B GLY A 1 41  ? 4.52277   24.41954 40.03387 0.500 72.90238  ? 36  GLY A C   1 
ATOM   346  O O   A GLY A 1 41  ? 3.21289   24.11163 39.78785 0.500 74.72097  ? 36  GLY A O   1 
ATOM   347  O O   B GLY A 1 41  ? 3.54330   23.93411 40.61378 0.500 76.43786  ? 36  GLY A O   1 
ATOM   348  N N   . SER A 1 42  ? 4.76001   25.73215 40.00400 1.000 62.58897  ? 37  SER A N   1 
ATOM   349  C CA  . SER A 1 42  ? 3.83244   26.70360 40.55802 1.000 70.10590  ? 37  SER A CA  1 
ATOM   350  C C   . SER A 1 42  ? 4.09298   28.03368 39.88055 1.000 57.94425  ? 37  SER A C   1 
ATOM   351  O O   . SER A 1 42  ? 5.23890   28.36219 39.57678 1.000 49.66512  ? 37  SER A O   1 
ATOM   352  C CB  . SER A 1 42  ? 3.99792   26.83714 42.08046 1.000 62.30266  ? 37  SER A CB  1 
ATOM   353  O OG  . SER A 1 42  ? 3.47490   25.69615 42.74121 1.000 76.59867  ? 37  SER A OG  1 
ATOM   354  N N   . VAL A 1 43  ? 3.02796   28.79905 39.65815 1.000 48.03540  ? 38  VAL A N   1 
ATOM   355  C CA  . VAL A 1 43  ? 3.11817   30.12010 39.04971 1.000 39.97707  ? 38  VAL A CA  1 
ATOM   356  C C   . VAL A 1 43  ? 2.65145   31.19308 40.02866 1.000 54.80232  ? 38  VAL A C   1 
ATOM   357  O O   . VAL A 1 43  ? 1.67523   31.01117 40.76369 1.000 53.79419  ? 38  VAL A O   1 
ATOM   358  C CB  . VAL A 1 43  ? 2.33071   30.19775 37.72816 1.000 43.97365  ? 38  VAL A CB  1 
ATOM   359  C CG1 . VAL A 1 43  ? 2.55792   31.53961 37.07025 1.000 44.85273  ? 38  VAL A CG1 1 
ATOM   360  C CG2 . VAL A 1 43  ? 2.78455   29.08503 36.78189 1.000 42.26125  ? 38  VAL A CG2 1 
ATOM   361  N N   . CYS A 1 44  ? 3.35685   32.31984 40.02855 1.000 46.40718  ? 39  CYS A N   1 
ATOM   362  C CA  . CYS A 1 44  ? 2.97339   33.49347 40.79432 1.000 44.97921  ? 39  CYS A CA  1 
ATOM   363  C C   . CYS A 1 44  ? 2.91361   34.67381 39.84184 1.000 53.15345  ? 39  CYS A C   1 
ATOM   364  O O   . CYS A 1 44  ? 3.75286   34.79458 38.94476 1.000 43.21178  ? 39  CYS A O   1 
ATOM   365  C CB  . CYS A 1 44  ? 3.98178   33.79426 41.87510 1.000 42.58350  ? 39  CYS A CB  1 
ATOM   366  S SG  . CYS A 1 44  ? 3.74044   32.94752 43.42566 1.000 62.67004  ? 39  CYS A SG  1 
ATOM   367  N N   . ALA A 1 45  ? 1.92069   35.53008 40.02260 1.000 55.68973  ? 40  ALA A N   1 
ATOM   368  C CA  . ALA A 1 45  ? 1.91674   36.82879 39.37688 1.000 44.30573  ? 40  ALA A CA  1 
ATOM   369  C C   . ALA A 1 45  ? 2.79138   37.77597 40.18226 1.000 40.98753  ? 40  ALA A C   1 
ATOM   370  O O   . ALA A 1 45  ? 2.88893   37.66487 41.40557 1.000 45.40611  ? 40  ALA A O   1 
ATOM   371  C CB  . ALA A 1 45  ? 0.49199   37.37619 39.28031 1.000 54.41047  ? 40  ALA A CB  1 
ATOM   372  N N   . ALA A 1 46  ? 3.44322   38.70085 39.48351 1.000 42.40544  ? 41  ALA A N   1 
ATOM   373  C CA  . ALA A 1 46  ? 4.30605   39.65946 40.14839 1.000 42.80006  ? 41  ALA A CA  1 
ATOM   374  C C   . ALA A 1 46  ? 4.39484   40.90518 39.28477 1.000 39.27536  ? 41  ALA A C   1 
ATOM   375  O O   . ALA A 1 46  ? 4.03665   40.90175 38.09523 1.000 49.22080  ? 41  ALA A O   1 
ATOM   376  C CB  . ALA A 1 46  ? 5.70337   39.07391 40.42431 1.000 43.45031  ? 41  ALA A CB  1 
ATOM   377  N N   . PHE A 1 47  ? 4.92015   41.95999 39.88831 1.000 40.95121  ? 42  PHE A N   1 
ATOM   378  C CA  . PHE A 1 47  ? 5.18692   43.20426 39.18985 1.000 50.23722  ? 42  PHE A CA  1 
ATOM   379  C C   . PHE A 1 47  ? 6.68537   43.33090 39.03736 1.000 46.88868  ? 42  PHE A C   1 
ATOM   380  O O   . PHE A 1 47  ? 7.40220   43.32214 40.04661 1.000 39.43780  ? 42  PHE A O   1 
ATOM   381  C CB  . PHE A 1 47  ? 4.61573   44.41248 39.92709 1.000 42.83232  ? 42  PHE A CB  1 
ATOM   382  C CG  . PHE A 1 47  ? 4.78193   45.69205 39.16191 1.000 52.22069  ? 42  PHE A CG  1 
ATOM   383  C CD1 . PHE A 1 47  ? 3.99951   45.94824 38.04702 1.000 63.41752  ? 42  PHE A CD1 1 
ATOM   384  C CD2 . PHE A 1 47  ? 5.70911   46.64039 39.55876 1.000 53.62759  ? 42  PHE A CD2 1 
ATOM   385  C CE1 . PHE A 1 47  ? 4.14716   47.11809 37.32310 1.000 63.07691  ? 42  PHE A CE1 1 
ATOM   386  C CE2 . PHE A 1 47  ? 5.85992   47.81948 38.84499 1.000 64.63034  ? 42  PHE A CE2 1 
ATOM   387  C CZ  . PHE A 1 47  ? 5.07522   48.05919 37.71948 1.000 56.24346  ? 42  PHE A CZ  1 
ATOM   388  N N   . ASP A 1 48  ? 7.15198   43.44592 37.78425 1.000 34.58962  ? 43  ASP A N   1 
ATOM   389  C CA  . ASP A 1 48  ? 8.57968   43.61280 37.50526 1.000 38.96186  ? 43  ASP A CA  1 
ATOM   390  C C   . ASP A 1 48  ? 8.91001   45.09567 37.51984 1.000 53.77340  ? 43  ASP A C   1 
ATOM   391  O O   . ASP A 1 48  ? 8.76509   45.78655 36.50563 1.000 45.35662  ? 43  ASP A O   1 
ATOM   392  C CB  . ASP A 1 48  ? 8.97429   43.00856 36.16231 1.000 39.42327  ? 43  ASP A CB  1 
ATOM   393  C CG  . ASP A 1 48  ? 10.45971  43.22535 35.84265 1.000 49.98319  ? 43  ASP A CG  1 
ATOM   394  O OD1 . ASP A 1 48  ? 11.21135  43.72052 36.72108 1.000 42.93914  ? 43  ASP A OD1 1 
ATOM   395  O OD2 . ASP A 1 48  ? 10.89092  42.92765 34.70563 1.000 56.72499  ? 43  ASP A OD2 1 
ATOM   396  N N   . THR A 1 49  ? 9.39503   45.58313 38.66280 1.000 49.66726  ? 44  THR A N   1 
ATOM   397  C CA  . THR A 1 49  ? 9.61176   47.01260 38.79300 1.000 55.62412  ? 44  THR A CA  1 
ATOM   398  C C   . THR A 1 49  ? 10.66893  47.51216 37.82584 1.000 44.53107  ? 44  THR A C   1 
ATOM   399  O O   . THR A 1 49  ? 10.69831  48.71234 37.52483 1.000 54.69394  ? 44  THR A O   1 
ATOM   400  C CB  . THR A 1 49  ? 9.99547   47.36332 40.23461 1.000 43.02411  ? 44  THR A CB  1 
ATOM   401  O OG1 . THR A 1 49  ? 11.08751  46.54095 40.66621 1.000 47.41850  ? 44  THR A OG1 1 
ATOM   402  C CG2 . THR A 1 49  ? 8.81137   47.11814 41.13665 1.000 48.15257  ? 44  THR A CG2 1 
ATOM   403  N N   . LYS A 1 50  ? 11.52465  46.62568 37.30423 1.000 40.89475  ? 45  LYS A N   1 
ATOM   404  C CA  . LYS A 1 50  ? 12.56080  47.10130 36.40029 1.000 47.48705  ? 45  LYS A CA  1 
ATOM   405  C C   . LYS A 1 50  ? 12.03588  47.36547 35.00314 1.000 45.64847  ? 45  LYS A C   1 
ATOM   406  O O   . LYS A 1 50  ? 12.64033  48.14945 34.27064 1.000 44.11465  ? 45  LYS A O   1 
ATOM   407  C CB  . LYS A 1 50  ? 13.71377  46.10501 36.32902 1.000 50.88273  ? 45  LYS A CB  1 
ATOM   408  C CG  . LYS A 1 50  ? 14.97912  46.57106 37.06472 1.000 68.38382  ? 45  LYS A CG  1 
ATOM   409  C CD  . LYS A 1 50  ? 14.72030  46.74793 38.56609 1.000 71.18312  ? 45  LYS A CD  1 
ATOM   410  C CE  . LYS A 1 50  ? 15.93586  46.36754 39.42183 1.000 76.76940  ? 45  LYS A CE  1 
ATOM   411  N NZ  . LYS A 1 50  ? 15.60452  46.23627 40.89478 1.000 68.89868  ? 45  LYS A NZ  1 
ATOM   412  N N   . THR A 1 51  ? 10.94192  46.72254 34.61082 1.000 45.19378  ? 46  THR A N   1 
ATOM   413  C CA  . THR A 1 51  ? 10.36409  46.89968 33.28546 1.000 49.18707  ? 46  THR A CA  1 
ATOM   414  C C   . THR A 1 51  ? 8.96929   47.51136 33.31228 1.000 45.74470  ? 46  THR A C   1 
ATOM   415  O O   . THR A 1 51  ? 8.49403   47.96230 32.26806 1.000 49.10037  ? 46  THR A O   1 
ATOM   416  C CB  . THR A 1 51  ? 10.27490  45.55389 32.53841 1.000 48.20321  ? 46  THR A CB  1 
ATOM   417  O OG1 . THR A 1 51  ? 9.40827   44.67062 33.25331 1.000 44.63893  ? 46  THR A OG1 1 
ATOM   418  C CG2 . THR A 1 51  ? 11.64890  44.90891 32.38699 1.000 49.86570  ? 46  THR A CG2 1 
ATOM   419  N N   . GLY A 1 52  ? 8.30429   47.54058 34.46343 1.000 50.82570  ? 47  GLY A N   1 
ATOM   420  C CA  . GLY A 1 52  ? 6.93250   47.98914 34.52002 1.000 44.11618  ? 47  GLY A CA  1 
ATOM   421  C C   . GLY A 1 52  ? 5.90951   46.96697 34.07075 1.000 61.20315  ? 47  GLY A C   1 
ATOM   422  O O   . GLY A 1 52  ? 4.73389   47.31845 33.92240 1.000 51.21448  ? 47  GLY A O   1 
ATOM   423  N N   . LEU A 1 53  ? 6.31383   45.71640 33.84336 1.000 47.78282  ? 48  LEU A N   1 
ATOM   424  C CA  . LEU A 1 53  ? 5.42217   44.70118 33.29832 1.000 47.25893  ? 48  LEU A CA  1 
ATOM   425  C C   . LEU A 1 53  ? 4.83230   43.85668 34.40349 1.000 50.29479  ? 48  LEU A C   1 
ATOM   426  O O   . LEU A 1 53  ? 5.48710   43.58403 35.41471 1.000 48.17964  ? 48  LEU A O   1 
ATOM   427  C CB  . LEU A 1 53  ? 6.13624   43.76824 32.31743 1.000 49.39728  ? 48  LEU A CB  1 
ATOM   428  C CG  . LEU A 1 53  ? 6.95806   44.41259 31.21104 1.000 51.38597  ? 48  LEU A CG  1 
ATOM   429  C CD1 . LEU A 1 53  ? 7.87573   43.38082 30.58915 1.000 52.84283  ? 48  LEU A CD1 1 
ATOM   430  C CD2 . LEU A 1 53  ? 5.99507   45.00625 30.16810 1.000 51.58366  ? 48  LEU A CD2 1 
ATOM   431  N N   . ARG A 1 54  ? 3.59016   43.42953 34.18503 1.000 47.12774  ? 49  ARG A N   1 
ATOM   432  C CA  . ARG A 1 54  ? 3.00667   42.34462 34.96039 1.000 48.82305  ? 49  ARG A CA  1 
ATOM   433  C C   . ARG A 1 54  ? 3.53440   41.05182 34.38070 1.000 42.12763  ? 49  ARG A C   1 
ATOM   434  O O   . ARG A 1 54  ? 3.56304   40.88912 33.15824 1.000 46.22866  ? 49  ARG A O   1 
ATOM   435  C CB  . ARG A 1 54  ? 1.47441   42.36341 34.91474 1.000 48.87019  ? 49  ARG A CB  1 
ATOM   436  C CG  . ARG A 1 54  ? 0.83347   43.74666 34.85272 1.000 71.63032  ? 49  ARG A CG  1 
ATOM   437  C CD  . ARG A 1 54  ? 1.56493   44.74967 35.73435 1.000 86.46944  ? 49  ARG A CD  1 
ATOM   438  N NE  . ARG A 1 54  ? 1.07103   44.78101 37.10820 1.000 85.21031  ? 49  ARG A NE  1 
ATOM   439  C CZ  . ARG A 1 54  ? 0.37813   45.78389 37.63213 1.000 88.42563  ? 49  ARG A CZ  1 
ATOM   440  N NH1 . ARG A 1 54  ? 0.04740   46.84782 36.91382 1.000 88.62709  ? 49  ARG A NH1 1 
ATOM   441  N NH2 . ARG A 1 54  ? 0.00552   45.71741 38.90760 1.000 93.60903  ? 49  ARG A NH2 1 
ATOM   442  N N   . VAL A 1 55  ? 4.00560   40.15328 35.23719 1.000 34.45592  ? 50  VAL A N   1 
ATOM   443  C CA  . VAL A 1 55  ? 4.72139   38.99255 34.73903 1.000 41.33602  ? 50  VAL A CA  1 
ATOM   444  C C   . VAL A 1 55  ? 4.22003   37.77229 35.47187 1.000 41.71258  ? 50  VAL A C   1 
ATOM   445  O O   . VAL A 1 55  ? 3.76194   37.86396 36.61200 1.000 39.21687  ? 50  VAL A O   1 
ATOM   446  C CB  . VAL A 1 55  ? 6.24622   39.12146 34.95650 1.000 36.06176  ? 50  VAL A CB  1 
ATOM   447  C CG1 . VAL A 1 55  ? 6.80811   40.14085 34.01448 1.000 37.31810  ? 50  VAL A CG1 1 
ATOM   448  C CG2 . VAL A 1 55  ? 6.54699   39.45851 36.38668 1.000 35.43808  ? 50  VAL A CG2 1 
ATOM   449  N N   . ALA A 1 56  ? 4.35585   36.61814 34.82991 1.000 45.40706  ? 51  ALA A N   1 
ATOM   450  C CA  . ALA A 1 56  ? 4.17577   35.34076 35.49378 1.000 46.12997  ? 51  ALA A CA  1 
ATOM   451  C C   . ALA A 1 56  ? 5.56635   34.79378 35.76513 1.000 41.76983  ? 51  ALA A C   1 
ATOM   452  O O   . ALA A 1 56  ? 6.42021   34.81148 34.87487 1.000 39.07575  ? 51  ALA A O   1 
ATOM   453  C CB  . ALA A 1 56  ? 3.35169   34.36905 34.64159 1.000 43.54972  ? 51  ALA A CB  1 
ATOM   454  N N   . VAL A 1 57  ? 5.79659   34.38693 37.01254 1.000 38.43606  ? 52  VAL A N   1 
ATOM   455  C CA  . VAL A 1 57  ? 7.02059   33.74985 37.47776 1.000 40.58371  ? 52  VAL A CA  1 
ATOM   456  C C   . VAL A 1 57  ? 6.70236   32.29965 37.83038 1.000 33.25285  ? 52  VAL A C   1 
ATOM   457  O O   . VAL A 1 57  ? 5.90740   32.02425 38.73761 1.000 39.65456  ? 52  VAL A O   1 
ATOM   458  C CB  . VAL A 1 57  ? 7.60605   34.48075 38.69213 1.000 37.34823  ? 52  VAL A CB  1 
ATOM   459  C CG1 . VAL A 1 57  ? 8.92309   33.88293 39.07093 1.000 35.03798  ? 52  VAL A CG1 1 
ATOM   460  C CG2 . VAL A 1 57  ? 7.72737   35.97038 38.41795 1.000 48.35560  ? 52  VAL A CG2 1 
ATOM   461  N N   . LYS A 1 58  ? 7.28673   31.36258 37.09589 1.000 41.76589  ? 53  LYS A N   1 
ATOM   462  C CA  . LYS A 1 58  ? 7.00390   29.95428 37.30616 1.000 35.84546  ? 53  LYS A CA  1 
ATOM   463  C C   . LYS A 1 58  ? 8.22239   29.32449 37.95774 1.000 40.67245  ? 53  LYS A C   1 
ATOM   464  O O   . LYS A 1 58  ? 9.32577   29.41163 37.42502 1.000 38.28982  ? 53  LYS A O   1 
ATOM   465  C CB  . LYS A 1 58  ? 6.67137   29.23414 35.99614 1.000 44.92364  ? 53  LYS A CB  1 
ATOM   466  C CG  . LYS A 1 58  ? 6.66504   27.71949 36.13498 1.000 44.08037  ? 53  LYS A CG  1 
ATOM   467  C CD  . LYS A 1 58  ? 5.85183   27.03695 35.02729 1.000 54.00063  ? 53  LYS A CD  1 
ATOM   468  C CE  . LYS A 1 58  ? 6.69084   26.83561 33.77014 1.000 64.26920  ? 53  LYS A CE  1 
ATOM   469  N NZ  . LYS A 1 58  ? 5.94762   27.14389 32.50046 1.000 69.64882  ? 53  LYS A NZ  1 
ATOM   470  N N   A LYS A 1 59  ? 8.02476   28.72944 39.12516 0.600 41.22111  ? 54  LYS A N   1 
ATOM   471  N N   B LYS A 1 59  ? 8.02594   28.69109 39.10632 0.400 41.30580  ? 54  LYS A N   1 
ATOM   472  C CA  A LYS A 1 59  ? 9.06451   27.94225 39.77238 0.600 46.43094  ? 54  LYS A CA  1 
ATOM   473  C CA  B LYS A 1 59  ? 9.08644   27.95290 39.78357 0.400 46.38649  ? 54  LYS A CA  1 
ATOM   474  C C   A LYS A 1 59  ? 8.90487   26.49229 39.33374 0.600 46.41418  ? 54  LYS A C   1 
ATOM   475  C C   B LYS A 1 59  ? 8.93809   26.48446 39.39033 0.400 46.40308  ? 54  LYS A C   1 
ATOM   476  O O   A LYS A 1 59  ? 7.87182   25.86884 39.59767 0.600 41.09389  ? 54  LYS A O   1 
ATOM   477  O O   B LYS A 1 59  ? 7.95495   25.83202 39.75824 0.400 41.51290  ? 54  LYS A O   1 
ATOM   478  C CB  A LYS A 1 59  ? 8.97411   28.06178 41.29277 0.600 49.44666  ? 54  LYS A CB  1 
ATOM   479  C CB  B LYS A 1 59  ? 9.00029   28.14034 41.29918 0.400 49.35754  ? 54  LYS A CB  1 
ATOM   480  C CG  A LYS A 1 59  ? 10.09109  27.32840 42.04864 0.600 44.47761  ? 54  LYS A CG  1 
ATOM   481  C CG  B LYS A 1 59  ? 10.05040  27.37062 42.09460 0.400 44.59589  ? 54  LYS A CG  1 
ATOM   482  C CD  A LYS A 1 59  ? 9.88599   27.40517 43.56890 0.600 48.99774  ? 54  LYS A CD  1 
ATOM   483  C CD  B LYS A 1 59  ? 9.84196   27.55731 43.59845 0.400 49.00316  ? 54  LYS A CD  1 
ATOM   484  C CE  A LYS A 1 59  ? 11.12587  26.95128 44.30685 0.600 51.66744  ? 54  LYS A CE  1 
ATOM   485  C CE  B LYS A 1 59  ? 10.88179  26.80349 44.40810 0.400 51.41651  ? 54  LYS A CE  1 
ATOM   486  N NZ  A LYS A 1 59  ? 10.81142  26.46711 45.67453 0.600 56.98846  ? 54  LYS A NZ  1 
ATOM   487  N NZ  B LYS A 1 59  ? 12.27524  27.03772 43.90442 0.400 47.89966  ? 54  LYS A NZ  1 
ATOM   488  N N   . LEU A 1 60  ? 9.90534   25.96708 38.63489 1.000 44.29604  ? 55  LEU A N   1 
ATOM   489  C CA  . LEU A 1 60  ? 9.81733   24.58831 38.17707 1.000 43.27369  ? 55  LEU A CA  1 
ATOM   490  C C   . LEU A 1 60  ? 9.79950   23.64284 39.36601 1.000 53.20947  ? 55  LEU A C   1 
ATOM   491  O O   . LEU A 1 60  ? 10.45776  23.87453 40.37711 1.000 48.14126  ? 55  LEU A O   1 
ATOM   492  C CB  . LEU A 1 60  ? 10.97483  24.23867 37.24135 1.000 41.65323  ? 55  LEU A CB  1 
ATOM   493  C CG  . LEU A 1 60  ? 10.94374  24.95045 35.89525 1.000 40.82218  ? 55  LEU A CG  1 
ATOM   494  C CD1 . LEU A 1 60  ? 12.07388  24.43262 34.98025 1.000 42.66018  ? 55  LEU A CD1 1 
ATOM   495  C CD2 . LEU A 1 60  ? 9.58578   24.79499 35.22620 1.000 40.66401  ? 55  LEU A CD2 1 
ATOM   496  N N   . SER A 1 61  ? 9.00344   22.59153 39.24911 1.000 63.00051  ? 56  SER A N   1 
ATOM   497  C CA  . SER A 1 61  ? 8.90982   21.55269 40.26033 1.000 59.24479  ? 56  SER A CA  1 
ATOM   498  C C   . SER A 1 61  ? 9.76113   20.36473 39.83156 1.000 49.20206  ? 56  SER A C   1 
ATOM   499  O O   . SER A 1 61  ? 9.56847   19.82072 38.73891 1.000 55.35020  ? 56  SER A O   1 
ATOM   500  C CB  . SER A 1 61  ? 7.45236   21.13041 40.45098 1.000 69.59557  ? 56  SER A CB  1 
ATOM   501  O OG  . SER A 1 61  ? 7.36863   19.96502 41.24835 1.000 71.23869  ? 56  SER A OG  1 
ATOM   502  N N   . ARG A 1 62  ? 10.68764  19.96199 40.68713 1.000 59.38683  ? 57  ARG A N   1 
ATOM   503  C CA  . ARG A 1 62  ? 11.41878  18.72217 40.45727 1.000 72.46130  ? 57  ARG A CA  1 
ATOM   504  C C   . ARG A 1 62  ? 12.12268  18.80121 39.11042 1.000 53.96206  ? 57  ARG A C   1 
ATOM   505  O O   . ARG A 1 62  ? 12.03945  17.85720 38.30965 1.000 54.09526  ? 57  ARG A O   1 
ATOM   506  C CB  . ARG A 1 62  ? 10.46857  17.51609 40.48165 1.000 68.35145  ? 57  ARG A CB  1 
ATOM   507  C CG  . ARG A 1 62  ? 9.39179   17.55595 41.56703 1.000 82.24389  ? 57  ARG A CG  1 
ATOM   508  C CD  . ARG A 1 62  ? 9.93129   17.15151 42.93501 1.000 91.17685  ? 57  ARG A CD  1 
ATOM   509  N NE  . ARG A 1 62  ? 10.93265  18.08714 43.43805 1.000 108.30299 ? 57  ARG A NE  1 
ATOM   510  C CZ  . ARG A 1 62  ? 11.82663  17.79600 44.37514 1.000 109.45861 ? 57  ARG A CZ  1 
ATOM   511  N NH1 . ARG A 1 62  ? 11.86686  16.60136 44.94519 1.000 96.03879  ? 57  ARG A NH1 1 
ATOM   512  N NH2 . ARG A 1 62  ? 12.70580  18.72471 44.74606 1.000 98.40767  ? 57  ARG A NH2 1 
ATOM   513  N N   . PRO A 1 63  ? 12.81693  19.90229 38.81604 1.000 54.78813  ? 58  PRO A N   1 
ATOM   514  C CA  . PRO A 1 63  ? 13.31223  20.08962 37.44315 1.000 51.99800  ? 58  PRO A CA  1 
ATOM   515  C C   . PRO A 1 63  ? 14.31536  19.02873 37.00757 1.000 46.34550  ? 58  PRO A C   1 
ATOM   516  O O   . PRO A 1 63  ? 14.39101  18.70959 35.80801 1.000 47.59052  ? 58  PRO A O   1 
ATOM   517  C CB  . PRO A 1 63  ? 13.93652  21.49611 37.48692 1.000 50.04184  ? 58  PRO A CB  1 
ATOM   518  C CG  . PRO A 1 63  ? 14.28896  21.73071 38.90341 1.000 52.60567  ? 58  PRO A CG  1 
ATOM   519  C CD  . PRO A 1 63  ? 13.27629  20.96681 39.72777 1.000 57.42451  ? 58  PRO A CD  1 
ATOM   520  N N   . PHE A 1 64  ? 15.11156  18.50509 37.94365 1.000 50.48861  ? 59  PHE A N   1 
ATOM   521  C CA  . PHE A 1 64  ? 16.16711  17.53804 37.65999 1.000 49.69653  ? 59  PHE A CA  1 
ATOM   522  C C   . PHE A 1 64  ? 15.92584  16.24255 38.42477 1.000 62.19561  ? 59  PHE A C   1 
ATOM   523  O O   . PHE A 1 64  ? 16.85480  15.53954 38.81590 1.000 51.87238  ? 59  PHE A O   1 
ATOM   524  C CB  . PHE A 1 64  ? 17.52106  18.15096 37.97052 1.000 48.01368  ? 59  PHE A CB  1 
ATOM   525  C CG  . PHE A 1 64  ? 17.69332  19.48697 37.32520 1.000 52.48880  ? 59  PHE A CG  1 
ATOM   526  C CD1 . PHE A 1 64  ? 17.68736  19.59646 35.94666 1.000 40.17307  ? 59  PHE A CD1 1 
ATOM   527  C CD2 . PHE A 1 64  ? 17.77539  20.63876 38.08614 1.000 44.45152  ? 59  PHE A CD2 1 
ATOM   528  C CE1 . PHE A 1 64  ? 17.82002  20.84733 35.33052 1.000 40.56967  ? 59  PHE A CE1 1 
ATOM   529  C CE2 . PHE A 1 64  ? 17.90851  21.87873 37.49427 1.000 46.59199  ? 59  PHE A CE2 1 
ATOM   530  C CZ  . PHE A 1 64  ? 17.91560  21.99109 36.10691 1.000 36.47165  ? 59  PHE A CZ  1 
ATOM   531  N N   . GLN A 1 65  ? 14.64540  15.93157 38.60365 1.000 52.68452  ? 60  GLN A N   1 
ATOM   532  C CA  . GLN A 1 65  ? 14.20776  14.74001 39.31915 1.000 64.14195  ? 60  GLN A CA  1 
ATOM   533  C C   . GLN A 1 65  ? 14.64168  13.45408 38.62279 1.000 62.65939  ? 60  GLN A C   1 
ATOM   534  O O   . GLN A 1 65  ? 15.15638  12.53573 39.26509 1.000 59.99205  ? 60  GLN A O   1 
ATOM   535  C CB  . GLN A 1 65  ? 12.69026  14.82412 39.45740 1.000 68.82791  ? 60  GLN A CB  1 
ATOM   536  C CG  . GLN A 1 65  ? 12.07557  14.04771 40.56342 1.000 86.87311  ? 60  GLN A CG  1 
ATOM   537  C CD  . GLN A 1 65  ? 11.13800  13.02594 40.00671 1.000 96.57784  ? 60  GLN A CD  1 
ATOM   538  O OE1 . GLN A 1 65  ? 11.51240  12.22966 39.14663 1.000 104.16357 ? 60  GLN A OE1 1 
ATOM   539  N NE2 . GLN A 1 65  ? 9.89337   13.04770 40.47386 1.000 88.01737  ? 60  GLN A NE2 1 
ATOM   540  N N   . SER A 1 66  ? 14.41163  13.35773 37.31449 1.000 53.80093  ? 61  SER A N   1 
ATOM   541  C CA  . SER A 1 66  ? 14.75798  12.19140 36.50922 1.000 55.56801  ? 61  SER A CA  1 
ATOM   542  C C   . SER A 1 66  ? 15.43814  12.62184 35.20940 1.000 54.09805  ? 61  SER A C   1 
ATOM   543  O O   . SER A 1 66  ? 15.47626  13.80758 34.85888 1.000 47.44267  ? 61  SER A O   1 
ATOM   544  C CB  . SER A 1 66  ? 13.51757  11.37197 36.17093 1.000 44.86060  ? 61  SER A CB  1 
ATOM   545  O OG  . SER A 1 66  ? 12.74082  12.09879 35.23214 1.000 52.14149  ? 61  SER A OG  1 
ATOM   546  N N   . ILE A 1 67  ? 15.96003  11.63796 34.46614 1.000 51.56176  ? 62  ILE A N   1 
ATOM   547  C CA  . ILE A 1 67  ? 16.56748  11.96635 33.17904 1.000 39.26288  ? 62  ILE A CA  1 
ATOM   548  C C   . ILE A 1 67  ? 15.51617  12.58740 32.26652 1.000 55.08895  ? 62  ILE A C   1 
ATOM   549  O O   . ILE A 1 67  ? 15.77036  13.58723 31.58065 1.000 51.62064  ? 62  ILE A O   1 
ATOM   550  C CB  . ILE A 1 67  ? 17.19795  10.71960 32.53585 1.000 62.96193  ? 62  ILE A CB  1 
ATOM   551  C CG1 . ILE A 1 67  ? 18.56021  10.41757 33.15452 1.000 55.83213  ? 62  ILE A CG1 1 
ATOM   552  C CG2 . ILE A 1 67  ? 17.40880  10.96578 31.04402 1.000 54.76462  ? 62  ILE A CG2 1 
ATOM   553  C CD1 . ILE A 1 67  ? 19.14126  9.10440  32.69338 1.000 57.49882  ? 62  ILE A CD1 1 
ATOM   554  N N   . ILE A 1 68  ? 14.31523  12.00043 32.24117 1.000 46.39101  ? 63  ILE A N   1 
ATOM   555  C CA  . ILE A 1 68  ? 13.22641  12.57112 31.45347 1.000 50.86549  ? 63  ILE A CA  1 
ATOM   556  C C   . ILE A 1 68  ? 12.92268  13.98943 31.92049 1.000 56.50233  ? 63  ILE A C   1 
ATOM   557  O O   . ILE A 1 68  ? 12.80668  14.91971 31.11159 1.000 44.53161  ? 63  ILE A O   1 
ATOM   558  C CB  . ILE A 1 68  ? 11.96738  11.68325 31.51544 1.000 57.50522  ? 63  ILE A CB  1 
ATOM   559  C CG1 . ILE A 1 68  ? 12.23050  10.26953 30.98575 1.000 69.73235  ? 63  ILE A CG1 1 
ATOM   560  C CG2 . ILE A 1 68  ? 10.81143  12.34042 30.77089 1.000 63.12929  ? 63  ILE A CG2 1 
ATOM   561  C CD1 . ILE A 1 68  ? 13.10986  9.41293  31.88108 1.000 62.10785  ? 63  ILE A CD1 1 
ATOM   562  N N   . HIS A 1 69  ? 12.78952  14.17520 33.23284 1.000 42.14477  ? 64  HIS A N   1 
ATOM   563  C CA  . HIS A 1 69  ? 12.48692  15.49972 33.75566 1.000 47.80401  ? 64  HIS A CA  1 
ATOM   564  C C   . HIS A 1 69  ? 13.59745  16.47742 33.38423 1.000 43.92265  ? 64  HIS A C   1 
ATOM   565  O O   . HIS A 1 69  ? 13.34152  17.57369 32.87660 1.000 42.22866  ? 64  HIS A O   1 
ATOM   566  C CB  . HIS A 1 69  ? 12.32287  15.43373 35.28124 1.000 51.60548  ? 64  HIS A CB  1 
ATOM   567  C CG  . HIS A 1 69  ? 10.95922  15.00205 35.73592 1.000 76.56047  ? 64  HIS A CG  1 
ATOM   568  N ND1 . HIS A 1 69  ? 10.55450  13.68081 35.74524 1.000 73.14711  ? 64  HIS A ND1 1 
ATOM   569  C CD2 . HIS A 1 69  ? 9.90182   15.72077 36.18371 1.000 73.21589  ? 64  HIS A CD2 1 
ATOM   570  C CE1 . HIS A 1 69  ? 9.30921   13.60580 36.18306 1.000 70.29381  ? 64  HIS A CE1 1 
ATOM   571  N NE2 . HIS A 1 69  ? 8.89047   14.82954 36.45567 1.000 76.19074  ? 64  HIS A NE2 1 
ATOM   572  N N   . ALA A 1 70  ? 14.84536  16.09857 33.66279 1.000 43.00404  ? 65  ALA A N   1 
ATOM   573  C CA  . ALA A 1 70  ? 15.96299  16.98799 33.39503 1.000 46.57786  ? 65  ALA A CA  1 
ATOM   574  C C   . ALA A 1 70  ? 16.01022  17.37291 31.92527 1.000 36.66266  ? 65  ALA A C   1 
ATOM   575  O O   . ALA A 1 70  ? 16.27133  18.53241 31.58442 1.000 41.59113  ? 65  ALA A O   1 
ATOM   576  C CB  . ALA A 1 70  ? 17.27370  16.32766 33.83180 1.000 40.16323  ? 65  ALA A CB  1 
ATOM   577  N N   . LYS A 1 71  ? 15.79179  16.41395 31.03763 1.000 38.18770  ? 66  LYS A N   1 
ATOM   578  C CA  . LYS A 1 71  ? 15.78932  16.73766 29.61715 1.000 41.12394  ? 66  LYS A CA  1 
ATOM   579  C C   . LYS A 1 71  ? 14.60965  17.62936 29.26150 1.000 41.46095  ? 66  LYS A C   1 
ATOM   580  O O   . LYS A 1 71  ? 14.73486  18.52458 28.42483 1.000 38.95721  ? 66  LYS A O   1 
ATOM   581  C CB  . LYS A 1 71  ? 15.76335  15.46196 28.77502 1.000 40.44938  ? 66  LYS A CB  1 
ATOM   582  C CG  . LYS A 1 71  ? 16.07986  15.70308 27.28949 1.000 41.41911  ? 66  LYS A CG  1 
ATOM   583  C CD  . LYS A 1 71  ? 16.08698  14.39897 26.48150 1.000 49.31627  ? 66  LYS A CD  1 
ATOM   584  C CE  . LYS A 1 71  ? 16.04323  14.66222 24.98552 1.000 49.17325  ? 66  LYS A CE  1 
ATOM   585  N NZ  . LYS A 1 71  ? 16.08412  13.38889 24.18728 1.000 56.45423  ? 66  LYS A NZ  1 
ATOM   586  N N   . ARG A 1 72  ? 13.46047  17.42415 29.89851 1.000 38.97388  ? 67  ARG A N   1 
ATOM   587  C CA  . ARG A 1 72  ? 12.32076  18.27840 29.58035 1.000 42.64919  ? 67  ARG A CA  1 
ATOM   588  C C   . ARG A 1 72  ? 12.55450  19.71013 30.07096 1.000 41.61633  ? 67  ARG A C   1 
ATOM   589  O O   . ARG A 1 72  ? 12.15741  20.67830 29.40257 1.000 36.81735  ? 67  ARG A O   1 
ATOM   590  C CB  . ARG A 1 72  ? 11.04978  17.67698 30.17721 1.000 39.25541  ? 67  ARG A CB  1 
ATOM   591  C CG  . ARG A 1 72  ? 9.77529   18.48246 29.87603 1.000 42.92039  ? 67  ARG A CG  1 
ATOM   592  C CD  . ARG A 1 72  ? 8.91805   18.62470 31.10557 1.000 62.23681  ? 67  ARG A CD  1 
ATOM   593  N NE  . ARG A 1 72  ? 9.44940   19.69049 31.94416 1.000 75.46386  ? 67  ARG A NE  1 
ATOM   594  C CZ  . ARG A 1 72  ? 9.11235   20.96890 31.84229 1.000 71.52498  ? 67  ARG A CZ  1 
ATOM   595  N NH1 . ARG A 1 72  ? 8.19127   21.37661 30.98384 1.000 69.32307  ? 67  ARG A NH1 1 
ATOM   596  N NH2 . ARG A 1 72  ? 9.73014   21.86286 32.60642 1.000 54.84561  ? 67  ARG A NH2 1 
ATOM   597  N N   . THR A 1 73  ? 13.19427  19.86002 31.23829 1.000 35.40597  ? 68  THR A N   1 
ATOM   598  C CA  . THR A 1 73  ? 13.57391  21.18932 31.71870 1.000 33.77576  ? 68  THR A CA  1 
ATOM   599  C C   . THR A 1 73  ? 14.45601  21.89768 30.69080 1.000 35.71308  ? 68  THR A C   1 
ATOM   600  O O   . THR A 1 73  ? 14.23363  23.06770 30.34803 1.000 33.06770  ? 68  THR A O   1 
ATOM   601  C CB  . THR A 1 73  ? 14.31291  21.07811 33.06062 1.000 38.14348  ? 68  THR A CB  1 
ATOM   602  O OG1 . THR A 1 73  ? 13.46160  20.45805 34.04128 1.000 40.63157  ? 68  THR A OG1 1 
ATOM   603  C CG2 . THR A 1 73  ? 14.77360  22.47169 33.55863 1.000 36.30879  ? 68  THR A CG2 1 
ATOM   604  N N   . TYR A 1 74  ? 15.46881  21.18953 30.18652 1.000 36.47246  ? 69  TYR A N   1 
ATOM   605  C CA  . TYR A 1 74  ? 16.37480  21.77035 29.19413 1.000 33.09035  ? 69  TYR A CA  1 
ATOM   606  C C   . TYR A 1 74  ? 15.64028  22.13917 27.91579 1.000 31.44486  ? 69  TYR A C   1 
ATOM   607  O O   . TYR A 1 74  ? 15.88906  23.20549 27.32084 1.000 33.39872  ? 69  TYR A O   1 
ATOM   608  C CB  . TYR A 1 74  ? 17.49785  20.78286 28.88536 1.000 38.05635  ? 69  TYR A CB  1 
ATOM   609  C CG  . TYR A 1 74  ? 18.48935  21.30484 27.86333 1.000 32.03962  ? 69  TYR A CG  1 
ATOM   610  C CD1 . TYR A 1 74  ? 19.36465  22.34373 28.18290 1.000 33.26315  ? 69  TYR A CD1 1 
ATOM   611  C CD2 . TYR A 1 74  ? 18.49420  20.78717 26.56348 1.000 34.87652  ? 69  TYR A CD2 1 
ATOM   612  C CE1 . TYR A 1 74  ? 20.26644  22.82399 27.25498 1.000 34.11158  ? 69  TYR A CE1 1 
ATOM   613  C CE2 . TYR A 1 74  ? 19.37360  21.24766 25.61344 1.000 38.44700  ? 69  TYR A CE2 1 
ATOM   614  C CZ  . TYR A 1 74  ? 20.26670  22.26319 25.95195 1.000 38.63197  ? 69  TYR A CZ  1 
ATOM   615  O OH  . TYR A 1 74  ? 21.14088  22.72422 24.99396 1.000 42.73149  ? 69  TYR A OH  1 
ATOM   616  N N   . ARG A 1 75  ? 14.72301  21.26926 27.47378 1.000 35.28507  ? 70  ARG A N   1 
ATOM   617  C CA  . ARG A 1 75  ? 13.95752  21.53456 26.25324 1.000 35.04911  ? 70  ARG A CA  1 
ATOM   618  C C   . ARG A 1 75  ? 13.09498  22.79030 26.38580 1.000 37.78808  ? 70  ARG A C   1 
ATOM   619  O O   . ARG A 1 75  ? 13.04883  23.62484 25.47335 1.000 33.05125  ? 70  ARG A O   1 
ATOM   620  C CB  . ARG A 1 75  ? 13.07367  20.32868 25.93534 1.000 37.29095  ? 70  ARG A CB  1 
ATOM   621  C CG  . ARG A 1 75  ? 12.05966  20.56968 24.81272 1.000 31.75698  ? 70  ARG A CG  1 
ATOM   622  C CD  . ARG A 1 75  ? 11.06676  19.38990 24.73389 1.000 39.33330  ? 70  ARG A CD  1 
ATOM   623  N NE  . ARG A 1 75  ? 11.73144  18.10759 24.51635 1.000 38.33764  ? 70  ARG A NE  1 
ATOM   624  C CZ  . ARG A 1 75  ? 11.70683  17.08489 25.36139 1.000 51.39806  ? 70  ARG A CZ  1 
ATOM   625  N NH1 . ARG A 1 75  ? 11.00046  17.12384 26.47473 1.000 50.84397  ? 70  ARG A NH1 1 
ATOM   626  N NH2 . ARG A 1 75  ? 12.44315  16.00992 25.10272 1.000 37.80732  ? 70  ARG A NH2 1 
ATOM   627  N N   . GLU A 1 76  ? 12.34686  22.90930 27.48958 1.000 36.44423  ? 71  GLU A N   1 
ATOM   628  C CA  . GLU A 1 76  ? 11.53520  24.10405 27.70288 1.000 33.46921  ? 71  GLU A CA  1 
ATOM   629  C C   . GLU A 1 76  ? 12.38421  25.36476 27.67294 1.000 35.00194  ? 71  GLU A C   1 
ATOM   630  O O   . GLU A 1 76  ? 12.01074  26.36527 27.04852 1.000 35.73157  ? 71  GLU A O   1 
ATOM   631  C CB  . GLU A 1 76  ? 10.77998  24.03851 29.04364 1.000 43.62419  ? 71  GLU A CB  1 
ATOM   632  C CG  . GLU A 1 76  ? 9.59843   24.98771 29.06777 1.000 41.07531  ? 71  GLU A CG  1 
ATOM   633  C CD  . GLU A 1 76  ? 8.82289   25.03010 30.39715 1.000 64.90986  ? 71  GLU A CD  1 
ATOM   634  O OE1 . GLU A 1 76  ? 9.01362   24.14473 31.25828 1.000 60.69924  ? 71  GLU A OE1 1 
ATOM   635  O OE2 . GLU A 1 76  ? 7.98778   25.95682 30.55657 1.000 46.39052  ? 71  GLU A OE2 1 
ATOM   636  N N   . LEU A 1 77  ? 13.50491  25.35450 28.39903 1.000 36.93940  ? 72  LEU A N   1 
ATOM   637  C CA  . LEU A 1 77  ? 14.37355  26.52521 28.43589 1.000 33.89552  ? 72  LEU A CA  1 
ATOM   638  C C   . LEU A 1 77  ? 14.88632  26.84822 27.04266 1.000 35.75068  ? 72  LEU A C   1 
ATOM   639  O O   . LEU A 1 77  ? 14.76497  27.98915 26.57748 1.000 36.66607  ? 72  LEU A O   1 
ATOM   640  C CB  . LEU A 1 77  ? 15.54279  26.29591 29.40650 1.000 35.16489  ? 72  LEU A CB  1 
ATOM   641  C CG  . LEU A 1 77  ? 16.37844  27.50906 29.80974 1.000 37.28200  ? 72  LEU A CG  1 
ATOM   642  C CD1 . LEU A 1 77  ? 15.52275  28.76385 29.98765 1.000 45.55931  ? 72  LEU A CD1 1 
ATOM   643  C CD2 . LEU A 1 77  ? 17.28211  27.21311 31.04464 1.000 44.37828  ? 72  LEU A CD2 1 
ATOM   644  N N   . ARG A 1 78  ? 15.41647  25.83850 26.33375 1.000 32.37244  ? 73  ARG A N   1 
ATOM   645  C CA  . ARG A 1 78  ? 15.91367  26.09397 24.97321 1.000 33.74982  ? 73  ARG A CA  1 
ATOM   646  C C   . ARG A 1 78  ? 14.80725  26.66632 24.11712 1.000 34.77806  ? 73  ARG A C   1 
ATOM   647  O O   . ARG A 1 78  ? 15.00588  27.64165 23.38211 1.000 34.72475  ? 73  ARG A O   1 
ATOM   648  C CB  . ARG A 1 78  ? 16.46548  24.81150 24.33181 1.000 34.23540  ? 73  ARG A CB  1 
ATOM   649  C CG  . ARG A 1 78  ? 17.83546  24.36036 24.84414 1.000 32.26729  ? 73  ARG A CG  1 
ATOM   650  C CD  . ARG A 1 78  ? 19.01682  25.30734 24.37917 1.000 36.72623  ? 73  ARG A CD  1 
ATOM   651  N NE  . ARG A 1 78  ? 18.97086  25.48996 22.93198 1.000 37.27839  ? 73  ARG A NE  1 
ATOM   652  C CZ  . ARG A 1 78  ? 19.29203  24.53917 22.06205 1.000 46.08914  ? 73  ARG A CZ  1 
ATOM   653  N NH1 . ARG A 1 78  ? 19.78961  23.37537 22.45884 1.000 36.49696  ? 73  ARG A NH1 1 
ATOM   654  N NH2 . ARG A 1 78  ? 19.13708  24.77168 20.76197 1.000 38.76282  ? 73  ARG A NH2 1 
ATOM   655  N N   A LEU A 1 79  ? 13.60845  26.10325 24.23141 0.600 33.63963  ? 74  LEU A N   1 
ATOM   656  N N   B LEU A 1 79  ? 13.62114  26.06187 24.19619 0.400 33.74564  ? 74  LEU A N   1 
ATOM   657  C CA  A LEU A 1 79  ? 12.50403  26.55784 23.40423 0.600 34.36113  ? 74  LEU A CA  1 
ATOM   658  C CA  B LEU A 1 79  ? 12.47806  26.54316 23.43284 0.400 34.48248  ? 74  LEU A CA  1 
ATOM   659  C C   A LEU A 1 79  ? 12.12050  27.99901 23.74723 0.600 32.83382  ? 74  LEU A C   1 
ATOM   660  C C   B LEU A 1 79  ? 12.16696  27.99950 23.75694 0.400 32.95638  ? 74  LEU A C   1 
ATOM   661  O O   A LEU A 1 79  ? 11.99521  28.85298 22.85947 0.600 33.38981  ? 74  LEU A O   1 
ATOM   662  O O   B LEU A 1 79  ? 12.08760  28.85014 22.86251 0.400 33.50011  ? 74  LEU A O   1 
ATOM   663  C CB  A LEU A 1 79  ? 11.32678  25.60197 23.58626 0.600 39.38759  ? 74  LEU A CB  1 
ATOM   664  C CB  B LEU A 1 79  ? 11.26013  25.67200 23.72908 0.400 39.47072  ? 74  LEU A CB  1 
ATOM   665  C CG  A LEU A 1 79  ? 11.25118  24.43517 22.59512 0.600 45.38471  ? 74  LEU A CG  1 
ATOM   666  C CG  B LEU A 1 79  ? 10.37276  25.17503 22.58939 0.400 47.96292  ? 74  LEU A CG  1 
ATOM   667  C CD1 A LEU A 1 79  ? 10.50960  23.25131 23.20080 0.600 44.99646  ? 74  LEU A CD1 1 
ATOM   668  C CD1 B LEU A 1 79  ? 11.05917  25.37242 21.24068 0.400 47.58052  ? 74  LEU A CD1 1 
ATOM   669  C CD2 A LEU A 1 79  ? 10.61152  24.87638 21.28958 0.600 48.82879  ? 74  LEU A CD2 1 
ATOM   670  C CD2 B LEU A 1 79  ? 9.97485   23.71390 22.80617 0.400 48.55277  ? 74  LEU A CD2 1 
ATOM   671  N N   . LEU A 1 80  ? 11.98273  28.30632 25.03827 1.000 33.34202  ? 75  LEU A N   1 
ATOM   672  C CA  . LEU A 1 80  ? 11.57478  29.65607 25.41608 1.000 44.06159  ? 75  LEU A CA  1 
ATOM   673  C C   . LEU A 1 80  ? 12.64335  30.69656 25.07902 1.000 37.23068  ? 75  LEU A C   1 
ATOM   674  O O   . LEU A 1 80  ? 12.31870  31.81149 24.63858 1.000 36.14708  ? 75  LEU A O   1 
ATOM   675  C CB  . LEU A 1 80  ? 11.24968  29.68516 26.90053 1.000 39.15574  ? 75  LEU A CB  1 
ATOM   676  C CG  . LEU A 1 80  ? 9.92381   28.98456 27.23512 1.000 39.33047  ? 75  LEU A CG  1 
ATOM   677  C CD1 . LEU A 1 80  ? 9.84277   28.71539 28.72589 1.000 41.51746  ? 75  LEU A CD1 1 
ATOM   678  C CD2 . LEU A 1 80  ? 8.71573   29.76010 26.73905 1.000 46.59420  ? 75  LEU A CD2 1 
ATOM   679  N N   . LYS A 1 81  ? 13.92258  30.37845 25.32042 1.000 37.76077  ? 76  LYS A N   1 
ATOM   680  C CA  . LYS A 1 81  ? 14.96750  31.32515 24.96227 1.000 37.05083  ? 76  LYS A CA  1 
ATOM   681  C C   . LYS A 1 81  ? 14.94938  31.59845 23.46687 1.000 35.67866  ? 76  LYS A C   1 
ATOM   682  O O   . LYS A 1 81  ? 15.41159  32.64331 23.01770 1.000 39.31126  ? 76  LYS A O   1 
ATOM   683  C CB  . LYS A 1 81  ? 16.35126  30.80285 25.37377 1.000 35.62384  ? 76  LYS A CB  1 
ATOM   684  C CG  . LYS A 1 81  ? 16.66277  30.89127 26.85601 1.000 36.35477  ? 76  LYS A CG  1 
ATOM   685  C CD  . LYS A 1 81  ? 18.06764  30.38509 27.16933 1.000 39.58301  ? 76  LYS A CD  1 
ATOM   686  C CE  . LYS A 1 81  ? 19.13824  31.32933 26.60927 1.000 40.51617  ? 76  LYS A CE  1 
ATOM   687  N NZ  . LYS A 1 81  ? 20.43749  31.07002 27.24401 1.000 39.76443  ? 76  LYS A NZ  1 
ATOM   688  N N   . HIS A 1 82  ? 14.46350  30.66213 22.67213 1.000 32.12508  ? 77  HIS A N   1 
ATOM   689  C CA  . HIS A 1 82  ? 14.57676  30.86399 21.23292 1.000 36.60725  ? 77  HIS A CA  1 
ATOM   690  C C   . HIS A 1 82  ? 13.48836  31.75816 20.65544 1.000 41.08119  ? 77  HIS A C   1 
ATOM   691  O O   . HIS A 1 82  ? 13.71508  32.42062 19.63532 1.000 34.52015  ? 77  HIS A O   1 
ATOM   692  C CB  . HIS A 1 82  ? 14.54405  29.53200 20.49500 1.000 39.03786  ? 77  HIS A CB  1 
ATOM   693  C CG  . HIS A 1 82  ? 14.97454  29.65699 19.07112 1.000 42.33485  ? 77  HIS A CG  1 
ATOM   694  N ND1 . HIS A 1 82  ? 16.29814  29.56292 18.69789 1.000 51.01546  ? 77  HIS A ND1 1 
ATOM   695  C CD2 . HIS A 1 82  ? 14.27105  29.85226 17.93232 1.000 40.19679  ? 77  HIS A CD2 1 
ATOM   696  C CE1 . HIS A 1 82  ? 16.39508  29.70273 17.38779 1.000 55.59212  ? 77  HIS A CE1 1 
ATOM   697  N NE2 . HIS A 1 82  ? 15.18019  29.86596 16.89807 1.000 44.27228  ? 77  HIS A NE2 1 
ATOM   698  N N   . MET A 1 83  ? 12.30339  31.78020 21.25240 1.000 36.29266  ? 78  MET A N   1 
ATOM   699  C CA  . MET A 1 83  ? 11.14679  32.38959 20.59098 1.000 38.36476  ? 78  MET A CA  1 
ATOM   700  C C   . MET A 1 83  ? 11.19610  33.90948 20.67934 1.000 39.08921  ? 78  MET A C   1 
ATOM   701  O O   . MET A 1 83  ? 11.08080  34.47751 21.76640 1.000 48.13797  ? 78  MET A O   1 
ATOM   702  C CB  . MET A 1 83  ? 9.85015   31.86521 21.21140 1.000 36.28071  ? 78  MET A CB  1 
ATOM   703  C CG  . MET A 1 83  ? 9.85640   30.39889 21.15992 1.000 40.25807  ? 78  MET A CG  1 
ATOM   704  S SD  . MET A 1 83  ? 9.45774   29.80525 19.51600 1.000 50.26227  ? 78  MET A SD  1 
ATOM   705  C CE  . MET A 1 83  ? 8.64464   28.31523 19.99564 1.000 52.16755  ? 78  MET A CE  1 
ATOM   706  N N   . LYS A 1 84  ? 11.32758  34.57812 19.53724 1.000 35.93828  ? 79  LYS A N   1 
ATOM   707  C CA  . LYS A 1 84  ? 11.42808  36.03288 19.49404 1.000 44.30729  ? 79  LYS A CA  1 
ATOM   708  C C   . LYS A 1 84  ? 10.46229  36.51378 18.40269 1.000 48.35954  ? 79  LYS A C   1 
ATOM   709  O O   . LYS A 1 84  ? 10.89261  36.80021 17.27508 1.000 34.31153  ? 79  LYS A O   1 
ATOM   710  C CB  . LYS A 1 84  ? 12.89080  36.42892 19.20939 1.000 42.50420  ? 79  LYS A CB  1 
ATOM   711  C CG  . LYS A 1 84  ? 13.84716  36.01719 20.31541 1.000 49.25077  ? 79  LYS A CG  1 
ATOM   712  C CD  . LYS A 1 84  ? 14.60737  37.15551 20.91850 1.000 65.38177  ? 79  LYS A CD  1 
ATOM   713  C CE  . LYS A 1 84  ? 15.70285  36.61478 21.82879 1.000 72.79361  ? 79  LYS A CE  1 
ATOM   714  N NZ  . LYS A 1 84  ? 16.28834  37.70462 22.69792 1.000 80.21663  ? 79  LYS A NZ  1 
ATOM   715  N N   . HIS A 1 85  ? 9.16525   36.59136 18.73894 1.000 36.97714  ? 80  HIS A N   1 
ATOM   716  C CA  . HIS A 1 85  ? 8.14022   36.90443 17.74863 1.000 38.68471  ? 80  HIS A CA  1 
ATOM   717  C C   . HIS A 1 85  ? 6.93202   37.52661 18.42820 1.000 35.36307  ? 80  HIS A C   1 
ATOM   718  O O   . HIS A 1 85  ? 6.53933   37.10988 19.52404 1.000 35.12969  ? 80  HIS A O   1 
ATOM   719  C CB  . HIS A 1 85  ? 7.70808   35.63702 16.99894 1.000 41.70628  ? 80  HIS A CB  1 
ATOM   720  C CG  . HIS A 1 85  ? 6.81240   35.88389 15.82409 1.000 36.89933  ? 80  HIS A CG  1 
ATOM   721  N ND1 . HIS A 1 85  ? 5.44623   36.03780 15.94101 1.000 35.97548  ? 80  HIS A ND1 1 
ATOM   722  C CD2 . HIS A 1 85  ? 7.08679   35.95990 14.49912 1.000 38.39690  ? 80  HIS A CD2 1 
ATOM   723  C CE1 . HIS A 1 85  ? 4.91762   36.21542 14.73959 1.000 40.10374  ? 80  HIS A CE1 1 
ATOM   724  N NE2 . HIS A 1 85  ? 5.89283   36.16796 13.84839 1.000 35.80981  ? 80  HIS A NE2 1 
ATOM   725  N N   . GLU A 1 86  ? 6.30592   38.48259 17.73826 1.000 34.25311  ? 81  GLU A N   1 
ATOM   726  C CA  . GLU A 1 86  ? 5.18557   39.20354 18.33671 1.000 34.90080  ? 81  GLU A CA  1 
ATOM   727  C C   . GLU A 1 86  ? 4.02514   38.29118 18.70589 1.000 42.65901  ? 81  GLU A C   1 
ATOM   728  O O   . GLU A 1 86  ? 3.24772   38.63918 19.59399 1.000 35.96994  ? 81  GLU A O   1 
ATOM   729  C CB  . GLU A 1 86  ? 4.64327   40.28267 17.39255 1.000 50.65440  ? 81  GLU A CB  1 
ATOM   730  C CG  . GLU A 1 86  ? 5.64585   41.27918 16.79171 1.000 60.40097  ? 81  GLU A CG  1 
ATOM   731  C CD  . GLU A 1 86  ? 4.96726   42.30601 15.86226 1.000 77.01176  ? 81  GLU A CD  1 
ATOM   732  O OE1 . GLU A 1 86  ? 3.79282   42.09420 15.45775 1.000 60.22622  ? 81  GLU A OE1 1 
ATOM   733  O OE2 . GLU A 1 86  ? 5.61861   43.31291 15.51265 1.000 84.22943  ? 81  GLU A OE2 1 
ATOM   734  N N   . ASN A 1 87  ? 3.83075   37.16875 18.00046 1.000 36.21948  ? 82  ASN A N   1 
ATOM   735  C CA  . ASN A 1 87  ? 2.67325   36.31463 18.25323 1.000 38.07609  ? 82  ASN A CA  1 
ATOM   736  C C   . ASN A 1 87  ? 3.03209   35.04137 18.99442 1.000 35.41134  ? 82  ASN A C   1 
ATOM   737  O O   . ASN A 1 87  ? 2.29810   34.05115 18.91394 1.000 32.55881  ? 82  ASN A O   1 
ATOM   738  C CB  . ASN A 1 87  ? 1.95566   35.95768 16.94931 1.000 33.50576  ? 82  ASN A CB  1 
ATOM   739  C CG  . ASN A 1 87  ? 1.44429   37.19389 16.19621 1.000 43.44918  ? 82  ASN A CG  1 
ATOM   740  O OD1 . ASN A 1 87  ? 1.92733   37.52639 15.10465 1.000 36.67146  ? 82  ASN A OD1 1 
ATOM   741  N ND2 . ASN A 1 87  ? 0.50683   37.91891 16.82268 1.000 36.73931  ? 82  ASN A ND2 1 
ATOM   742  N N   . VAL A 1 88  ? 4.14511   35.03548 19.70426 1.000 34.61673  ? 83  VAL A N   1 
ATOM   743  C CA  . VAL A 1 88  ? 4.61078   33.85687 20.42376 1.000 33.59365  ? 83  VAL A CA  1 
ATOM   744  C C   . VAL A 1 88  ? 5.13087   34.31719 21.77900 1.000 33.98261  ? 83  VAL A C   1 
ATOM   745  O O   . VAL A 1 88  ? 5.85248   35.30911 21.86567 1.000 39.56001  ? 83  VAL A O   1 
ATOM   746  C CB  . VAL A 1 88  ? 5.73491   33.10730 19.66781 1.000 35.74758  ? 83  VAL A CB  1 
ATOM   747  C CG1 . VAL A 1 88  ? 6.12238   31.85586 20.44411 1.000 32.72064  ? 83  VAL A CG1 1 
ATOM   748  C CG2 . VAL A 1 88  ? 5.32693   32.77616 18.18694 1.000 33.96780  ? 83  VAL A CG2 1 
ATOM   749  N N   . ILE A 1 89  ? 4.81061   33.57979 22.83519 1.000 41.44534  ? 84  ILE A N   1 
ATOM   750  C CA  . ILE A 1 89  ? 5.32847   33.95963 24.14285 1.000 39.75224  ? 84  ILE A CA  1 
ATOM   751  C C   . ILE A 1 89  ? 6.84565   33.81643 24.13751 1.000 42.54999  ? 84  ILE A C   1 
ATOM   752  O O   . ILE A 1 89  ? 7.38283   32.79763 23.69139 1.000 50.48576  ? 84  ILE A O   1 
ATOM   753  C CB  . ILE A 1 89  ? 4.68606   33.11104 25.24897 1.000 50.94836  ? 84  ILE A CB  1 
ATOM   754  C CG1 . ILE A 1 89  ? 4.82862   33.80038 26.60999 1.000 52.23659  ? 84  ILE A CG1 1 
ATOM   755  C CG2 . ILE A 1 89  ? 5.29402   31.77743 25.28284 1.000 50.82812  ? 84  ILE A CG2 1 
ATOM   756  C CD1 . ILE A 1 89  ? 4.09263   35.16980 26.65508 1.000 65.36032  ? 84  ILE A CD1 1 
ATOM   757  N N   . GLY A 1 90  ? 7.54665   34.84510 24.61824 1.000 48.55164  ? 85  GLY A N   1 
ATOM   758  C CA  . GLY A 1 90  ? 8.98094   34.79078 24.80838 1.000 48.49032  ? 85  GLY A CA  1 
ATOM   759  C C   . GLY A 1 90  ? 9.34993   34.79959 26.29155 1.000 42.99365  ? 85  GLY A C   1 
ATOM   760  O O   . GLY A 1 90  ? 8.51488   34.95911 27.17673 1.000 52.28778  ? 85  GLY A O   1 
ATOM   761  N N   A LEU A 1 91  ? 10.63312  34.59689 26.54567 0.420 39.80972  ? 86  LEU A N   1 
ATOM   762  N N   B LEU A 1 91  ? 10.63481  34.64019 26.54461 0.580 39.77031  ? 86  LEU A N   1 
ATOM   763  C CA  A LEU A 1 91  ? 11.16574  34.61991 27.90311 0.420 38.38564  ? 86  LEU A CA  1 
ATOM   764  C CA  B LEU A 1 91  ? 11.15841  34.61342 27.90516 0.580 38.37577  ? 86  LEU A CA  1 
ATOM   765  C C   A LEU A 1 91  ? 11.57566  36.04366 28.26112 0.420 42.37649  ? 86  LEU A C   1 
ATOM   766  C C   B LEU A 1 91  ? 11.63153  36.00653 28.31036 0.580 42.44384  ? 86  LEU A C   1 
ATOM   767  O O   A LEU A 1 91  ? 12.38863  36.66050 27.56177 0.420 40.82541  ? 86  LEU A O   1 
ATOM   768  O O   B LEU A 1 91  ? 12.55654  36.56121 27.70230 0.580 40.10762  ? 86  LEU A O   1 
ATOM   769  C CB  A LEU A 1 91  ? 12.35813  33.67774 28.01722 0.420 36.26130  ? 86  LEU A CB  1 
ATOM   770  C CB  B LEU A 1 91  ? 12.30068  33.61391 27.98055 0.580 36.21381  ? 86  LEU A CB  1 
ATOM   771  C CG  A LEU A 1 91  ? 12.19256  32.36272 28.77345 0.420 43.41146  ? 86  LEU A CG  1 
ATOM   772  C CG  B LEU A 1 91  ? 12.87264  33.24897 29.33543 0.580 32.92126  ? 86  LEU A CG  1 
ATOM   773  C CD1 A LEU A 1 91  ? 13.56182  31.78115 29.09171 0.420 34.05243  ? 86  LEU A CD1 1 
ATOM   774  C CD1 B LEU A 1 91  ? 11.76355  32.65318 30.20219 0.580 37.20125  ? 86  LEU A CD1 1 
ATOM   775  C CD2 A LEU A 1 91  ? 11.34321  32.53178 30.02884 0.420 35.82336  ? 86  LEU A CD2 1 
ATOM   776  C CD2 B LEU A 1 91  ? 13.97315  32.25018 29.11243 0.580 33.47657  ? 86  LEU A CD2 1 
ATOM   777  N N   . LEU A 1 92  ? 11.01620  36.56866 29.34663 1.000 36.84553  ? 87  LEU A N   1 
ATOM   778  C CA  . LEU A 1 92  ? 11.49509  37.85359 29.83094 1.000 36.25174  ? 87  LEU A CA  1 
ATOM   779  C C   . LEU A 1 92  ? 12.76345  37.68475 30.62947 1.000 34.11494  ? 87  LEU A C   1 
ATOM   780  O O   . LEU A 1 92  ? 13.60470  38.58343 30.60926 1.000 41.24814  ? 87  LEU A O   1 
ATOM   781  C CB  . LEU A 1 92  ? 10.42870  38.52689 30.69147 1.000 28.78590  ? 87  LEU A CB  1 
ATOM   782  C CG  . LEU A 1 92  ? 9.21057   38.89615 29.82360 1.000 55.50371  ? 87  LEU A CG  1 
ATOM   783  C CD1 . LEU A 1 92  ? 8.12776   39.61102 30.62585 1.000 45.19740  ? 87  LEU A CD1 1 
ATOM   784  C CD2 . LEU A 1 92  ? 9.64800   39.73226 28.62969 1.000 44.08455  ? 87  LEU A CD2 1 
ATOM   785  N N   . ASP A 1 93  ? 12.91292  36.55725 31.33264 1.000 33.72816  ? 88  ASP A N   1 
ATOM   786  C CA  . ASP A 1 93  ? 13.96860  36.39605 32.32222 1.000 40.43593  ? 88  ASP A CA  1 
ATOM   787  C C   . ASP A 1 93  ? 13.93741  34.93854 32.76069 1.000 35.94764  ? 88  ASP A C   1 
ATOM   788  O O   . ASP A 1 93  ? 12.90909  34.26554 32.63139 1.000 33.88022  ? 88  ASP A O   1 
ATOM   789  C CB  . ASP A 1 93  ? 13.76601  37.33363 33.52724 1.000 32.54895  ? 88  ASP A CB  1 
ATOM   790  C CG  . ASP A 1 93  ? 14.99946  37.40304 34.46143 1.000 53.00552  ? 88  ASP A CG  1 
ATOM   791  O OD1 . ASP A 1 93  ? 16.13778  37.00257 34.05750 1.000 44.17827  ? 88  ASP A OD1 1 
ATOM   792  O OD2 . ASP A 1 93  ? 14.83228  37.92125 35.59835 1.000 44.65115  ? 88  ASP A OD2 1 
ATOM   793  N N   . VAL A 1 94  ? 15.09765  34.43019 33.16301 1.000 34.34179  ? 89  VAL A N   1 
ATOM   794  C CA  . VAL A 1 94  ? 15.20764  33.12767 33.81152 1.000 31.73817  ? 89  VAL A CA  1 
ATOM   795  C C   . VAL A 1 94  ? 16.27981  33.24381 34.89008 1.000 33.92275  ? 89  VAL A C   1 
ATOM   796  O O   . VAL A 1 94  ? 17.33423  33.83795 34.65993 1.000 36.25994  ? 89  VAL A O   1 
ATOM   797  C CB  . VAL A 1 94  ? 15.55268  32.01682 32.79425 1.000 39.15794  ? 89  VAL A CB  1 
ATOM   798  C CG1 . VAL A 1 94  ? 16.73712  32.43774 31.90243 1.000 39.61410  ? 89  VAL A CG1 1 
ATOM   799  C CG2 . VAL A 1 94  ? 15.85569  30.71866 33.53530 1.000 37.75312  ? 89  VAL A CG2 1 
ATOM   800  N N   . PHE A 1 95  ? 16.03362  32.68741 36.07331 1.000 38.36357  ? 90  PHE A N   1 
ATOM   801  C CA  . PHE A 1 95  ? 17.07213  32.85534 37.08438 1.000 39.27798  ? 90  PHE A CA  1 
ATOM   802  C C   . PHE A 1 95  ? 17.07972  31.67280 38.03341 1.000 36.97690  ? 90  PHE A C   1 
ATOM   803  O O   . PHE A 1 95  ? 16.15005  30.85013 38.05812 1.000 38.26278  ? 90  PHE A O   1 
ATOM   804  C CB  . PHE A 1 95  ? 16.88502  34.18020 37.83722 1.000 36.98946  ? 90  PHE A CB  1 
ATOM   805  C CG  . PHE A 1 95  ? 15.58620  34.25417 38.56731 1.000 38.79012  ? 90  PHE A CG  1 
ATOM   806  C CD1 . PHE A 1 95  ? 15.41583  33.58772 39.77739 1.000 33.78888  ? 90  PHE A CD1 1 
ATOM   807  C CD2 . PHE A 1 95  ? 14.51297  34.96194 38.02391 1.000 39.47276  ? 90  PHE A CD2 1 
ATOM   808  C CE1 . PHE A 1 95  ? 14.19274  33.63948 40.45170 1.000 38.35017  ? 90  PHE A CE1 1 
ATOM   809  C CE2 . PHE A 1 95  ? 13.28228  35.02298 38.68902 1.000 41.67727  ? 90  PHE A CE2 1 
ATOM   810  C CZ  . PHE A 1 95  ? 13.12867  34.33909 39.90543 1.000 37.36331  ? 90  PHE A CZ  1 
ATOM   811  N N   . THR A 1 96  ? 18.18898  31.56379 38.76810 1.000 32.56543  ? 91  THR A N   1 
ATOM   812  C CA  . THR A 1 96  ? 18.28554  30.64941 39.85017 1.000 42.54503  ? 91  THR A CA  1 
ATOM   813  C C   . THR A 1 96  ? 18.93850  31.41848 40.99082 1.000 38.95460  ? 91  THR A C   1 
ATOM   814  O O   . THR A 1 96  ? 19.84789  32.23306 40.75312 1.000 40.93310  ? 91  THR A O   1 
ATOM   815  C CB  . THR A 1 96  ? 19.11696  29.41055 39.48818 1.000 40.20293  ? 91  THR A CB  1 
ATOM   816  O OG1 . THR A 1 96  ? 19.28916  28.60510 40.65885 1.000 48.72038  ? 91  THR A OG1 1 
ATOM   817  C CG2 . THR A 1 96  ? 20.46623  29.80427 38.93282 1.000 36.14711  ? 91  THR A CG2 1 
ATOM   818  N N   . PRO A 1 97  ? 18.53739  31.14407 42.23619 1.000 41.06047  ? 92  PRO A N   1 
ATOM   819  C CA  . PRO A 1 97  ? 19.26311  31.72363 43.38409 1.000 42.03943  ? 92  PRO A CA  1 
ATOM   820  C C   . PRO A 1 97  ? 20.67888  31.15503 43.56380 1.000 53.83435  ? 92  PRO A C   1 
ATOM   821  O O   . PRO A 1 97  ? 21.49020  31.75796 44.27652 1.000 52.69297  ? 92  PRO A O   1 
ATOM   822  C CB  . PRO A 1 97  ? 18.36159  31.37444 44.58443 1.000 44.84656  ? 92  PRO A CB  1 
ATOM   823  C CG  . PRO A 1 97  ? 17.59683  30.13500 44.13705 1.000 55.01495  ? 92  PRO A CG  1 
ATOM   824  C CD  . PRO A 1 97  ? 17.40135  30.28965 42.65293 1.000 43.16700  ? 92  PRO A CD  1 
ATOM   825  N N   . ALA A 1 98  ? 21.00968  30.01927 42.95025 1.000 50.74062  ? 93  ALA A N   1 
ATOM   826  C CA  . ALA A 1 98  ? 22.32687  29.42483 43.16581 1.000 42.89558  ? 93  ALA A CA  1 
ATOM   827  C C   . ALA A 1 98  ? 23.42740  30.26517 42.52696 1.000 48.31019  ? 93  ALA A C   1 
ATOM   828  O O   . ALA A 1 98  ? 23.24071  30.89236 41.48414 1.000 47.73133  ? 93  ALA A O   1 
ATOM   829  C CB  . ALA A 1 98  ? 22.37940  28.00053 42.60533 1.000 45.27035  ? 93  ALA A CB  1 
ATOM   830  N N   . ARG A 1 99  ? 24.59999  30.25487 43.15504 1.000 48.00742  ? 94  ARG A N   1 
ATOM   831  C CA  . ARG A 1 99  ? 25.74711  30.99829 42.66090 1.000 57.98882  ? 94  ARG A CA  1 
ATOM   832  C C   . ARG A 1 99  ? 26.72790  30.12336 41.88325 1.000 61.49413  ? 94  ARG A C   1 
ATOM   833  O O   . ARG A 1 99  ? 27.62639  30.65886 41.22528 1.000 64.08486  ? 94  ARG A O   1 
ATOM   834  C CB  . ARG A 1 99  ? 26.45878  31.66111 43.84000 1.000 66.12679  ? 94  ARG A CB  1 
ATOM   835  C CG  . ARG A 1 99  ? 25.50214  32.39790 44.77799 1.000 56.10491  ? 94  ARG A CG  1 
ATOM   836  C CD  . ARG A 1 99  ? 26.24411  33.29745 45.74731 1.000 75.97864  ? 94  ARG A CD  1 
ATOM   837  N NE  . ARG A 1 99  ? 25.36747  33.80663 46.79663 1.000 81.20520  ? 94  ARG A NE  1 
ATOM   838  C CZ  . ARG A 1 99  ? 25.26690  35.08739 47.13194 1.000 88.61928  ? 94  ARG A CZ  1 
ATOM   839  N NH1 . ARG A 1 99  ? 25.96619  36.02478 46.50722 1.000 72.14871  ? 94  ARG A NH1 1 
ATOM   840  N NH2 . ARG A 1 99  ? 24.44337  35.43808 48.11723 1.000 85.30436  ? 94  ARG A NH2 1 
ATOM   841  N N   . SER A 1 100 ? 26.55945  28.80074 41.92125 1.000 52.94514  ? 95  SER A N   1 
ATOM   842  C CA  . SER A 1 100 ? 27.42136  27.88729 41.18649 1.000 44.35693  ? 95  SER A CA  1 
ATOM   843  C C   . SER A 1 100 ? 26.60670  26.68156 40.74204 1.000 47.60731  ? 95  SER A C   1 
ATOM   844  O O   . SER A 1 100 ? 25.51882  26.41541 41.25530 1.000 42.69480  ? 95  SER A O   1 
ATOM   845  C CB  . SER A 1 100 ? 28.58668  27.39769 42.04101 1.000 53.44770  ? 95  SER A CB  1 
ATOM   846  O OG  . SER A 1 100 ? 28.09799  26.53265 43.04972 1.000 54.67793  ? 95  SER A OG  1 
ATOM   847  N N   . LEU A 1 101 ? 27.16677  25.92100 39.80327 1.000 50.43351  ? 96  LEU A N   1 
ATOM   848  C CA  . LEU A 1 101 ? 26.50129  24.69317 39.38238 1.000 47.18419  ? 96  LEU A CA  1 
ATOM   849  C C   . LEU A 1 101 ? 26.35400  23.71341 40.53210 1.000 50.66684  ? 96  LEU A C   1 
ATOM   850  O O   . LEU A 1 101 ? 25.38538  22.95352 40.57571 1.000 51.66134  ? 96  LEU A O   1 
ATOM   851  C CB  . LEU A 1 101 ? 27.27270  24.05349 38.22553 1.000 52.69725  ? 96  LEU A CB  1 
ATOM   852  C CG  . LEU A 1 101 ? 26.80330  22.66677 37.75560 1.000 56.71445  ? 96  LEU A CG  1 
ATOM   853  C CD1 . LEU A 1 101 ? 25.49019  22.73965 36.97391 1.000 49.88140  ? 96  LEU A CD1 1 
ATOM   854  C CD2 . LEU A 1 101 ? 27.88836  22.01900 36.87114 1.000 52.05554  ? 96  LEU A CD2 1 
ATOM   855  N N   . GLU A 1 102 ? 27.30624  23.70921 41.46729 1.000 58.69312  ? 97  GLU A N   1 
ATOM   856  C CA  . GLU A 1 102 ? 27.26745  22.74461 42.56210 1.000 53.42163  ? 97  GLU A CA  1 
ATOM   857  C C   . GLU A 1 102 ? 26.02492  22.92348 43.42139 1.000 47.41135  ? 97  GLU A C   1 
ATOM   858  O O   . GLU A 1 102 ? 25.39974  21.94114 43.83765 1.000 61.48219  ? 97  GLU A O   1 
ATOM   859  C CB  . GLU A 1 102 ? 28.52639  22.85021 43.43440 1.000 63.51577  ? 97  GLU A CB  1 
ATOM   860  C CG  . GLU A 1 102 ? 29.90268  22.57403 42.78003 1.000 85.02338  ? 97  GLU A CG  1 
ATOM   861  C CD  . GLU A 1 102 ? 30.08465  23.13199 41.36593 1.000 85.46031  ? 97  GLU A CD  1 
ATOM   862  O OE1 . GLU A 1 102 ? 29.97144  24.36845 41.18642 1.000 73.53487  ? 97  GLU A OE1 1 
ATOM   863  O OE2 . GLU A 1 102 ? 30.36872  22.33865 40.43517 1.000 83.16800  ? 97  GLU A OE2 1 
ATOM   864  N N   . GLU A 1 103 ? 25.63253  24.17069 43.67921 1.000 49.50052  ? 98  GLU A N   1 
ATOM   865  C CA  . GLU A 1 103 ? 24.44103  24.44988 44.47007 1.000 57.42432  ? 98  GLU A CA  1 
ATOM   866  C C   . GLU A 1 103 ? 23.20284  24.73668 43.61563 1.000 59.44204  ? 98  GLU A C   1 
ATOM   867  O O   . GLU A 1 103 ? 22.21569  25.26734 44.13546 1.000 55.56652  ? 98  GLU A O   1 
ATOM   868  C CB  . GLU A 1 103 ? 24.71274  25.59320 45.45746 1.000 62.32948  ? 98  GLU A CB  1 
ATOM   869  C CG  . GLU A 1 103 ? 25.55179  26.76457 44.94988 1.000 64.96591  ? 98  GLU A CG  1 
ATOM   870  C CD  . GLU A 1 103 ? 25.32917  28.05856 45.75343 1.000 81.11887  ? 98  GLU A CD  1 
ATOM   871  O OE1 . GLU A 1 103 ? 25.94528  29.09318 45.41003 1.000 74.21595  ? 98  GLU A OE1 1 
ATOM   872  O OE2 . GLU A 1 103 ? 24.52686  28.04943 46.71808 1.000 81.06161  ? 98  GLU A OE2 1 
ATOM   873  N N   . PHE A 1 104 ? 23.21661  24.35590 42.33225 1.000 54.76210  ? 99  PHE A N   1 
ATOM   874  C CA  . PHE A 1 104 ? 22.09321  24.62530 41.43603 1.000 45.01178  ? 99  PHE A CA  1 
ATOM   875  C C   . PHE A 1 104 ? 21.01087  23.55141 41.60150 1.000 54.66286  ? 99  PHE A C   1 
ATOM   876  O O   . PHE A 1 104 ? 21.28496  22.35347 41.48740 1.000 54.29846  ? 99  PHE A O   1 
ATOM   877  C CB  . PHE A 1 104 ? 22.60730  24.69604 39.99497 1.000 53.47757  ? 99  PHE A CB  1 
ATOM   878  C CG  . PHE A 1 104 ? 21.52948  24.84962 38.93318 1.000 47.74368  ? 99  PHE A CG  1 
ATOM   879  C CD1 . PHE A 1 104 ? 20.52786  25.81699 39.04618 1.000 42.82913  ? 99  PHE A CD1 1 
ATOM   880  C CD2 . PHE A 1 104 ? 21.57075  24.07681 37.77689 1.000 40.58291  ? 99  PHE A CD2 1 
ATOM   881  C CE1 . PHE A 1 104 ? 19.56202  25.97679 38.03796 1.000 43.34497  ? 99  PHE A CE1 1 
ATOM   882  C CE2 . PHE A 1 104 ? 20.59718  24.23276 36.75224 1.000 42.62769  ? 99  PHE A CE2 1 
ATOM   883  C CZ  . PHE A 1 104 ? 19.59997  25.17898 36.89050 1.000 40.83174  ? 99  PHE A CZ  1 
ATOM   884  N N   . ASN A 1 105 ? 19.77734  23.98328 41.88563 1.000 51.81674  ? 100 ASN A N   1 
ATOM   885  C CA  . ASN A 1 105 ? 18.63579  23.08028 42.03700 1.000 52.59536  ? 100 ASN A CA  1 
ATOM   886  C C   . ASN A 1 105 ? 17.33354  23.62028 41.47214 1.000 46.18194  ? 100 ASN A C   1 
ATOM   887  O O   . ASN A 1 105 ? 16.46292  22.82167 41.11786 1.000 66.56155  ? 100 ASN A O   1 
ATOM   888  C CB  . ASN A 1 105 ? 18.39957  22.75063 43.51586 1.000 59.95217  ? 100 ASN A CB  1 
ATOM   889  C CG  . ASN A 1 105 ? 19.55744  22.01404 44.13596 1.000 69.48373  ? 100 ASN A CG  1 
ATOM   890  O OD1 . ASN A 1 105 ? 19.96963  20.96575 43.63757 1.000 72.86681  ? 100 ASN A OD1 1 
ATOM   891  N ND2 . ASN A 1 105 ? 20.09379  22.55516 45.23018 1.000 58.72526  ? 100 ASN A ND2 1 
ATOM   892  N N   . ASP A 1 106 ? 17.14159  24.93010 41.40746 1.000 49.88264  ? 101 ASP A N   1 
ATOM   893  C CA  . ASP A 1 106 ? 15.85208  25.50948 41.07823 1.000 52.87243  ? 101 ASP A CA  1 
ATOM   894  C C   . ASP A 1 106 ? 15.98964  26.44530 39.89215 1.000 44.00961  ? 101 ASP A C   1 
ATOM   895  O O   . ASP A 1 106 ? 16.98199  27.17564 39.76997 1.000 42.29036  ? 101 ASP A O   1 
ATOM   896  C CB  . ASP A 1 106 ? 15.26955  26.26672 42.27891 1.000 53.08433  ? 101 ASP A CB  1 
ATOM   897  C CG  . ASP A 1 106 ? 14.83429  25.33505 43.40674 1.000 66.74822  ? 101 ASP A CG  1 
ATOM   898  O OD1 . ASP A 1 106 ? 14.39064  24.19057 43.13523 1.000 79.25449  ? 101 ASP A OD1 1 
ATOM   899  O OD2 . ASP A 1 106 ? 14.95244  25.74991 44.57108 1.000 58.37248  ? 101 ASP A OD2 1 
ATOM   900  N N   A VAL A 1 107 ? 14.97547  26.42093 39.03535 0.600 44.81161  ? 102 VAL A N   1 
ATOM   901  N N   B VAL A 1 107 ? 14.99686  26.41781 39.01044 0.400 44.79123  ? 102 VAL A N   1 
ATOM   902  C CA  A VAL A 1 107 ? 14.87383  27.27785 37.86232 0.600 40.79909  ? 102 VAL A CA  1 
ATOM   903  C CA  B VAL A 1 107 ? 14.94282  27.34060 37.88651 0.400 40.87375  ? 102 VAL A CA  1 
ATOM   904  C C   A VAL A 1 107 ? 13.55858  28.04127 37.95115 0.600 39.08124  ? 102 VAL A C   1 
ATOM   905  C C   B VAL A 1 107 ? 13.58988  28.03937 37.91412 0.400 39.18017  ? 102 VAL A C   1 
ATOM   906  O O   A VAL A 1 107 ? 12.50601  27.44756 38.21969 0.600 40.11253  ? 102 VAL A O   1 
ATOM   907  O O   B VAL A 1 107 ? 12.54760  27.40693 38.12556 0.400 40.23273  ? 102 VAL A O   1 
ATOM   908  C CB  A VAL A 1 107 ? 14.95510  26.46272 36.55509 0.600 44.28707  ? 102 VAL A CB  1 
ATOM   909  C CB  B VAL A 1 107 ? 15.17531  26.63786 36.52897 0.400 44.70146  ? 102 VAL A CB  1 
ATOM   910  C CG1 A VAL A 1 107 ? 15.26851  27.36268 35.38315 0.600 34.55990  ? 102 VAL A CG1 1 
ATOM   911  C CG1 B VAL A 1 107 ? 15.57542  25.18656 36.73579 0.400 51.09818  ? 102 VAL A CG1 1 
ATOM   912  C CG2 A VAL A 1 107 ? 16.02374  25.38992 36.67190 0.600 51.33759  ? 102 VAL A CG2 1 
ATOM   913  C CG2 B VAL A 1 107 ? 13.96048  26.77654 35.62440 0.400 38.31601  ? 102 VAL A CG2 1 
ATOM   914  N N   . TYR A 1 108 ? 13.61188  29.34777 37.69825 1.000 39.33438  ? 103 TYR A N   1 
ATOM   915  C CA  . TYR A 1 108 ? 12.41862  30.18910 37.67541 1.000 40.60650  ? 103 TYR A CA  1 
ATOM   916  C C   . TYR A 1 108 ? 12.34678  30.81107 36.30061 1.000 36.49170  ? 103 TYR A C   1 
ATOM   917  O O   . TYR A 1 108 ? 13.35125  31.31661 35.81712 1.000 36.44978  ? 103 TYR A O   1 
ATOM   918  C CB  . TYR A 1 108 ? 12.46296  31.31212 38.71937 1.000 36.19450  ? 103 TYR A CB  1 
ATOM   919  C CG  . TYR A 1 108 ? 12.48863  30.90538 40.13694 1.000 48.86347  ? 103 TYR A CG  1 
ATOM   920  C CD1 . TYR A 1 108 ? 13.63970  30.39642 40.70850 1.000 40.99851  ? 103 TYR A CD1 1 
ATOM   921  C CD2 . TYR A 1 108 ? 11.36004  31.07847 40.93562 1.000 39.83981  ? 103 TYR A CD2 1 
ATOM   922  C CE1 . TYR A 1 108 ? 13.66544  30.04251 42.03783 1.000 42.83739  ? 103 TYR A CE1 1 
ATOM   923  C CE2 . TYR A 1 108 ? 11.37255  30.70866 42.27245 1.000 47.00878  ? 103 TYR A CE2 1 
ATOM   924  C CZ  . TYR A 1 108 ? 12.52830  30.21205 42.81678 1.000 42.89448  ? 103 TYR A CZ  1 
ATOM   925  O OH  . TYR A 1 108 ? 12.57797  29.85293 44.14700 1.000 40.51076  ? 103 TYR A OH  1 
ATOM   926  N N   . LEU A 1 109 ? 11.17287  30.78714 35.67846 1.000 39.29380  ? 104 LEU A N   1 
ATOM   927  C CA  . LEU A 1 109 ? 11.00014  31.33023 34.34041 1.000 34.20533  ? 104 LEU A CA  1 
ATOM   928  C C   . LEU A 1 109 ? 9.99554   32.47299 34.40801 1.000 34.62642  ? 104 LEU A C   1 
ATOM   929  O O   . LEU A 1 109 ? 8.92450   32.33041 35.00889 1.000 38.74747  ? 104 LEU A O   1 
ATOM   930  C CB  . LEU A 1 109 ? 10.50392  30.24605 33.37818 1.000 38.48122  ? 104 LEU A CB  1 
ATOM   931  C CG  . LEU A 1 109 ? 11.34811  28.97943 33.19243 1.000 35.04194  ? 104 LEU A CG  1 
ATOM   932  C CD1 . LEU A 1 109 ? 10.53087  27.91092 32.50072 1.000 39.31820  ? 104 LEU A CD1 1 
ATOM   933  C CD2 . LEU A 1 109 ? 12.68661  29.25772 32.43588 1.000 38.09913  ? 104 LEU A CD2 1 
ATOM   934  N N   . VAL A 1 110 ? 10.31468  33.58507 33.76183 1.000 36.03108  ? 105 VAL A N   1 
ATOM   935  C CA  . VAL A 1 110 ? 9.50771   34.79475 33.85474 1.000 38.14315  ? 105 VAL A CA  1 
ATOM   936  C C   . VAL A 1 110 ? 9.02180   35.13706 32.45462 1.000 41.49957  ? 105 VAL A C   1 
ATOM   937  O O   . VAL A 1 110 ? 9.81882   35.21967 31.51263 1.000 38.51478  ? 105 VAL A O   1 
ATOM   938  C CB  . VAL A 1 110 ? 10.30539  35.96329 34.45535 1.000 35.77278  ? 105 VAL A CB  1 
ATOM   939  C CG1 . VAL A 1 110 ? 9.46580   37.22470 34.45399 1.000 37.81928  ? 105 VAL A CG1 1 
ATOM   940  C CG2 . VAL A 1 110 ? 10.85824  35.59588 35.87415 1.000 35.01127  ? 105 VAL A CG2 1 
ATOM   941  N N   . THR A 1 111 ? 7.71131   35.26324 32.30736 1.000 41.14597  ? 106 THR A N   1 
ATOM   942  C CA  . THR A 1 111 ? 7.08877   35.62476 31.04959 1.000 33.44099  ? 106 THR A CA  1 
ATOM   943  C C   . THR A 1 111 ? 6.03742   36.70918 31.27456 1.000 45.59400  ? 106 THR A C   1 
ATOM   944  O O   . THR A 1 111 ? 5.72533   37.08384 32.40276 1.000 39.92044  ? 106 THR A O   1 
ATOM   945  C CB  . THR A 1 111 ? 6.44938   34.38715 30.40026 1.000 49.39644  ? 106 THR A CB  1 
ATOM   946  O OG1 . THR A 1 111 ? 5.21770   34.11580 31.08188 1.000 46.65503  ? 106 THR A OG1 1 
ATOM   947  C CG2 . THR A 1 111 ? 7.35544   33.15685 30.49058 1.000 51.38707  ? 106 THR A CG2 1 
ATOM   948  N N   . HIS A 1 112 ? 5.48615   37.21210 30.17315 1.000 40.39279  ? 107 HIS A N   1 
ATOM   949  C CA  . HIS A 1 112 ? 4.37303   38.14885 30.23280 1.000 55.13726  ? 107 HIS A CA  1 
ATOM   950  C C   . HIS A 1 112 ? 3.18486   37.50862 30.93503 1.000 54.42062  ? 107 HIS A C   1 
ATOM   951  O O   . HIS A 1 112 ? 2.80153   36.37689 30.62308 1.000 44.62108  ? 107 HIS A O   1 
ATOM   952  C CB  . HIS A 1 112 ? 3.96890   38.55861 28.81685 1.000 55.04666  ? 107 HIS A CB  1 
ATOM   953  C CG  . HIS A 1 112 ? 4.83194   39.62389 28.22597 1.000 51.76069  ? 107 HIS A CG  1 
ATOM   954  N ND1 . HIS A 1 112 ? 4.98312   40.86724 28.79951 1.000 53.65155  ? 107 HIS A ND1 1 
ATOM   955  C CD2 . HIS A 1 112 ? 5.63542   39.61185 27.13382 1.000 64.15169  ? 107 HIS A CD2 1 
ATOM   956  C CE1 . HIS A 1 112 ? 5.81904   41.58681 28.06943 1.000 52.43256  ? 107 HIS A CE1 1 
ATOM   957  N NE2 . HIS A 1 112 ? 6.23173   40.84751 27.05481 1.000 60.43715  ? 107 HIS A NE2 1 
ATOM   958  N N   . LEU A 1 113 ? 2.60349   38.23617 31.88785 1.000 50.17980  ? 108 LEU A N   1 
ATOM   959  C CA  . LEU A 1 113 ? 1.32415   37.83079 32.44229 1.000 59.83242  ? 108 LEU A CA  1 
ATOM   960  C C   . LEU A 1 113 ? 0.27872   38.05420 31.36048 1.000 57.24199  ? 108 LEU A C   1 
ATOM   961  O O   . LEU A 1 113 ? 0.13421   39.16809 30.84339 1.000 58.63447  ? 108 LEU A O   1 
ATOM   962  C CB  . LEU A 1 113 ? 0.99378   38.63755 33.69285 1.000 51.13625  ? 108 LEU A CB  1 
ATOM   963  C CG  . LEU A 1 113 ? -0.20048  38.14064 34.51639 1.000 55.32458  ? 108 LEU A CG  1 
ATOM   964  C CD1 . LEU A 1 113 ? -0.00145  36.71120 34.97513 1.000 42.42199  ? 108 LEU A CD1 1 
ATOM   965  C CD2 . LEU A 1 113 ? -0.47409  39.03601 35.72218 1.000 55.94784  ? 108 LEU A CD2 1 
ATOM   966  N N   A MET A 1 114 ? -0.41573  36.99004 30.98958 0.670 62.18571  ? 109 MET A N   1 
ATOM   967  N N   B MET A 1 114 ? -0.43617  36.99929 30.98707 0.330 62.20974  ? 109 MET A N   1 
ATOM   968  C CA  A MET A 1 114 ? -1.51078  37.06887 30.03526 0.670 66.06165  ? 109 MET A CA  1 
ATOM   969  C CA  B MET A 1 114 ? -1.31531  37.06590 29.81148 0.330 65.75656  ? 109 MET A CA  1 
ATOM   970  C C   A MET A 1 114 ? -2.80517  36.78200 30.78066 0.670 63.46470  ? 109 MET A C   1 
ATOM   971  C C   B MET A 1 114 ? -2.69355  37.61905 30.16427 0.330 66.09617  ? 109 MET A C   1 
ATOM   972  O O   A MET A 1 114 ? -2.88914  35.80958 31.53768 0.670 64.27563  ? 109 MET A O   1 
ATOM   973  O O   B MET A 1 114 ? -3.04022  38.73924 29.77799 0.330 66.36394  ? 109 MET A O   1 
ATOM   974  C CB  A MET A 1 114 ? -1.31246  36.08770 28.87454 0.670 65.91615  ? 109 MET A CB  1 
ATOM   975  C CB  B MET A 1 114 ? -1.41745  35.68909 29.15317 0.330 63.98463  ? 109 MET A CB  1 
ATOM   976  C CG  A MET A 1 114 ? -0.04493  36.35280 28.03628 0.670 63.97184  ? 109 MET A CG  1 
ATOM   977  C CG  B MET A 1 114 ? -0.15762  35.28718 28.39651 0.330 63.80119  ? 109 MET A CG  1 
ATOM   978  S SD  A MET A 1 114 ? 0.00010   37.94207 27.15251 0.670 74.15775  ? 109 MET A SD  1 
ATOM   979  S SD  B MET A 1 114 ? 0.86322   36.70290 27.94181 0.330 60.70369  ? 109 MET A SD  1 
ATOM   980  C CE  A MET A 1 114 ? -1.73792  38.20067 26.73843 0.670 63.15622  ? 109 MET A CE  1 
ATOM   981  C CE  B MET A 1 114 ? -0.05255  37.38073 26.54932 0.330 65.46247  ? 109 MET A CE  1 
ATOM   982  N N   A GLY A 1 115 ? -3.79722  37.64258 30.59080 0.670 68.75321  ? 110 GLY A N   1 
ATOM   983  N N   B GLY A 1 115 ? -3.48835  36.84020 30.89031 0.330 66.02075  ? 110 GLY A N   1 
ATOM   984  C CA  A GLY A 1 115 ? -5.05885  37.47157 31.28059 0.670 72.11201  ? 110 GLY A CA  1 
ATOM   985  C CA  B GLY A 1 115 ? -4.85157  37.23864 31.17802 0.330 71.51676  ? 110 GLY A CA  1 
ATOM   986  C C   A GLY A 1 115 ? -6.00992  36.54445 30.55633 0.670 66.41244  ? 110 GLY A C   1 
ATOM   987  C C   B GLY A 1 115 ? -5.87760  36.41270 30.43017 0.330 66.25815  ? 110 GLY A C   1 
ATOM   988  O O   A GLY A 1 115 ? -6.28101  35.42816 31.00882 0.670 67.28858  ? 110 GLY A O   1 
ATOM   989  O O   B GLY A 1 115 ? -6.09593  35.24356 30.76071 0.330 65.98400  ? 110 GLY A O   1 
ATOM   990  N N   . ALA A 1 116 ? -6.51081  36.99662 29.41566 1.000 57.77773  ? 111 ALA A N   1 
ATOM   991  C CA  . ALA A 1 116 ? -7.56165  36.29421 28.69953 1.000 60.32673  ? 111 ALA A CA  1 
ATOM   992  C C   . ALA A 1 116 ? -6.95793  35.34802 27.67475 1.000 54.90859  ? 111 ALA A C   1 
ATOM   993  O O   . ALA A 1 116 ? -6.02711  35.71845 26.95619 1.000 49.29457  ? 111 ALA A O   1 
ATOM   994  C CB  . ALA A 1 116 ? -8.49218  37.29424 28.01670 1.000 59.67477  ? 111 ALA A CB  1 
ATOM   995  N N   . ASP A 1 117 ? -7.46854  34.12280 27.62541 1.000 53.11734  ? 112 ASP A N   1 
ATOM   996  C CA  . ASP A 1 117 ? -7.17083  33.24168 26.50904 1.000 54.22548  ? 112 ASP A CA  1 
ATOM   997  C C   . ASP A 1 117 ? -8.37618  33.18017 25.58535 1.000 52.74166  ? 112 ASP A C   1 
ATOM   998  O O   . ASP A 1 117 ? -9.45259  33.69741 25.88820 1.000 52.38650  ? 112 ASP A O   1 
ATOM   999  C CB  . ASP A 1 117 ? -6.76160  31.84508 26.99149 1.000 52.50264  ? 112 ASP A CB  1 
ATOM   1000 C CG  . ASP A 1 117 ? -7.83976  31.13925 27.78750 1.000 68.56575  ? 112 ASP A CG  1 
ATOM   1001 O OD1 . ASP A 1 117 ? -9.04137  31.38276 27.51106 1.000 56.40117  ? 112 ASP A OD1 1 
ATOM   1002 O OD2 . ASP A 1 117 ? -7.47035  30.33481 28.68888 1.000 57.60577  ? 112 ASP A OD2 1 
ATOM   1003 N N   . LEU A 1 118 ? -8.17108  32.55636 24.42966 1.000 46.95778  ? 113 LEU A N   1 
ATOM   1004 C CA  . LEU A 1 118 ? -9.21428  32.48440 23.41825 1.000 47.60329  ? 113 LEU A CA  1 
ATOM   1005 C C   . LEU A 1 118 ? -10.49655 31.88884 23.97286 1.000 59.21655  ? 113 LEU A C   1 
ATOM   1006 O O   . LEU A 1 118 ? -11.58797 32.24392 23.52269 1.000 59.75400  ? 113 LEU A O   1 
ATOM   1007 C CB  . LEU A 1 118 ? -8.72949  31.66624 22.22392 1.000 55.08058  ? 113 LEU A CB  1 
ATOM   1008 C CG  . LEU A 1 118 ? -9.50676  31.96184 20.95766 1.000 54.49108  ? 113 LEU A CG  1 
ATOM   1009 C CD1 . LEU A 1 118 ? -9.42588  33.44705 20.68133 1.000 59.10533  ? 113 LEU A CD1 1 
ATOM   1010 C CD2 . LEU A 1 118 ? -8.95357  31.17197 19.79862 1.000 53.14698  ? 113 LEU A CD2 1 
ATOM   1011 N N   . ASN A 1 119 ? -10.38665 30.98133 24.94172 1.000 48.48063  ? 114 ASN A N   1 
ATOM   1012 C CA  . ASN A 1 119 ? -11.58130 30.43567 25.57704 1.000 66.62266  ? 114 ASN A CA  1 
ATOM   1013 C C   . ASN A 1 119 ? -12.44154 31.54298 26.16339 1.000 65.59943  ? 114 ASN A C   1 
ATOM   1014 O O   . ASN A 1 119 ? -13.63215 31.65431 25.85260 1.000 76.70086  ? 114 ASN A O   1 
ATOM   1015 C CB  . ASN A 1 119 ? -11.18195 29.43485 26.65899 1.000 67.67439  ? 114 ASN A CB  1 
ATOM   1016 C CG  . ASN A 1 119 ? -11.14169 28.03032 26.14211 1.000 64.33697  ? 114 ASN A CG  1 
ATOM   1017 O OD1 . ASN A 1 119 ? -11.77730 27.72553 25.13036 1.000 71.07052  ? 114 ASN A OD1 1 
ATOM   1018 N ND2 . ASN A 1 119 ? -10.36612 27.16845 26.79749 1.000 67.41428  ? 114 ASN A ND2 1 
ATOM   1019 N N   . ASN A 1 120 ? -11.84853 32.37403 27.02311 1.000 73.23693  ? 115 ASN A N   1 
ATOM   1020 C CA  . ASN A 1 120 ? -12.56311 33.48664 27.63769 1.000 76.70757  ? 115 ASN A CA  1 
ATOM   1021 C C   . ASN A 1 120 ? -13.27730 34.34292 26.60695 1.000 85.04022  ? 115 ASN A C   1 
ATOM   1022 O O   . ASN A 1 120 ? -14.18953 35.09932 26.96528 1.000 96.61328  ? 115 ASN A O   1 
ATOM   1023 C CB  . ASN A 1 120 ? -11.57537 34.35158 28.41973 1.000 66.11577  ? 115 ASN A CB  1 
ATOM   1024 C CG  . ASN A 1 120 ? -10.87411 33.57808 29.49706 1.000 73.48606  ? 115 ASN A CG  1 
ATOM   1025 O OD1 . ASN A 1 120 ? -9.75664  33.91423 29.88766 1.000 78.23085  ? 115 ASN A OD1 1 
ATOM   1026 N ND2 . ASN A 1 120 ? -11.52244 32.52270 29.98592 1.000 77.08702  ? 115 ASN A ND2 1 
ATOM   1027 N N   . ILE A 1 121 ? -12.88957 34.23553 25.33588 1.000 73.37687  ? 116 ILE A N   1 
ATOM   1028 C CA  . ILE A 1 121 ? -13.35509 35.14670 24.29809 1.000 84.62195  ? 116 ILE A CA  1 
ATOM   1029 C C   . ILE A 1 121 ? -14.54699 34.57203 23.54417 1.000 84.78967  ? 116 ILE A C   1 
ATOM   1030 O O   . ILE A 1 121 ? -15.60660 35.20647 23.46631 1.000 88.98532  ? 116 ILE A O   1 
ATOM   1031 C CB  . ILE A 1 121 ? -12.19629 35.49535 23.34975 1.000 82.01773  ? 116 ILE A CB  1 
ATOM   1032 C CG1 . ILE A 1 121 ? -10.97615 35.87346 24.19022 1.000 78.95641  ? 116 ILE A CG1 1 
ATOM   1033 C CG2 . ILE A 1 121 ? -12.60448 36.57682 22.36866 1.000 84.96606  ? 116 ILE A CG2 1 
ATOM   1034 C CD1 . ILE A 1 121 ? -11.31806 36.65958 25.46168 1.000 77.92259  ? 116 ILE A CD1 1 
ATOM   1035 N N   . VAL A 1 122 ? -14.40165 33.35013 23.01754 1.000 64.70086  ? 117 VAL A N   1 
ATOM   1036 C CA  . VAL A 1 122 ? -15.49609 32.67917 22.31856 1.000 84.70095  ? 117 VAL A CA  1 
ATOM   1037 C C   . VAL A 1 122 ? -16.69527 32.57222 23.26892 1.000 92.03666  ? 117 VAL A C   1 
ATOM   1038 O O   . VAL A 1 122 ? -17.82136 32.23964 22.86231 1.000 96.64789  ? 117 VAL A O   1 
ATOM   1039 C CB  . VAL A 1 122 ? -15.05455 31.29696 21.78325 1.000 88.13015  ? 117 VAL A CB  1 
ATOM   1040 C CG1 . VAL A 1 122 ? -15.04325 30.28366 22.91400 1.000 88.39739  ? 117 VAL A CG1 1 
ATOM   1041 C CG2 . VAL A 1 122 ? -16.00212 30.82377 20.65483 1.000 67.89904  ? 117 VAL A CG2 1 
ATOM   1042 N N   . LYS A 1 123 ? -16.45846 32.85216 24.55635 1.000 96.42974  ? 118 LYS A N   1 
ATOM   1043 C CA  . LYS A 1 123 ? -17.50737 32.81907 25.57914 1.000 100.16087 ? 118 LYS A CA  1 
ATOM   1044 C C   . LYS A 1 123 ? -17.80080 34.19714 26.17218 1.000 102.72721 ? 118 LYS A C   1 
ATOM   1045 O O   . LYS A 1 123 ? -17.65831 34.39991 27.38448 1.000 100.67033 ? 118 LYS A O   1 
ATOM   1046 C CB  . LYS A 1 123 ? -17.12371 31.84445 26.70466 1.000 93.62348  ? 118 LYS A CB  1 
ATOM   1047 C CG  . LYS A 1 123 ? -17.20790 30.35808 26.35405 1.000 83.86065  ? 118 LYS A CG  1 
ATOM   1048 C CD  . LYS A 1 123 ? -18.10858 30.04980 25.14721 1.000 100.51515 ? 118 LYS A CD  1 
ATOM   1049 C CE  . LYS A 1 123 ? -19.45757 30.78440 25.19453 1.000 85.61306  ? 118 LYS A CE  1 
ATOM   1050 N NZ  . LYS A 1 123 ? -20.33081 30.41035 24.05021 1.000 84.80695  ? 118 LYS A NZ  1 
ATOM   1051 N N   . CYS A 1 124 ? -18.18771 35.15594 25.32792 1.000 97.55654  ? 119 CYS A N   1 
ATOM   1052 C CA  . CYS A 1 124 ? -18.62609 36.46923 25.79713 1.000 99.77470  ? 119 CYS A CA  1 
ATOM   1053 C C   . CYS A 1 124 ? -18.84308 37.41303 24.61785 1.000 103.27398 ? 119 CYS A C   1 
ATOM   1054 O O   . CYS A 1 124 ? -19.03348 38.62148 24.80532 1.000 94.99502  ? 119 CYS A O   1 
ATOM   1055 C CB  . CYS A 1 124 ? -17.62310 37.07138 26.79148 1.000 101.41064 ? 119 CYS A CB  1 
ATOM   1056 S SG  . CYS A 1 124 ? -16.20179 37.92136 26.05610 1.000 126.76307 ? 119 CYS A SG  1 
ATOM   1057 N N   . GLN A 1 125 ? -18.80285 36.87308 23.40034 1.000 95.37353  ? 120 GLN A N   1 
ATOM   1058 C CA  . GLN A 1 125 ? -19.17871 37.63124 22.21300 1.000 96.59031  ? 120 GLN A CA  1 
ATOM   1059 C C   . GLN A 1 125 ? -19.24835 36.69380 21.02191 1.000 91.70267  ? 120 GLN A C   1 
ATOM   1060 O O   . GLN A 1 125 ? -18.57786 35.65675 20.99200 1.000 91.84856  ? 120 GLN A O   1 
ATOM   1061 C CB  . GLN A 1 125 ? -18.19642 38.76805 21.91561 1.000 93.36107  ? 120 GLN A CB  1 
ATOM   1062 C CG  . GLN A 1 125 ? -16.81692 38.54968 22.48876 1.000 96.46709  ? 120 GLN A CG  1 
ATOM   1063 C CD  . GLN A 1 125 ? -15.93071 39.74493 22.29278 1.000 95.24858  ? 120 GLN A CD  1 
ATOM   1064 O OE1 . GLN A 1 125 ? -16.14271 40.54956 21.38346 1.000 92.93139  ? 120 GLN A OE1 1 
ATOM   1065 N NE2 . GLN A 1 125 ? -14.94173 39.88685 23.16010 1.000 97.29416  ? 120 GLN A NE2 1 
ATOM   1066 N N   . LYS A 1 126 ? -20.09019 37.06132 20.05689 1.000 94.45987  ? 121 LYS A N   1 
ATOM   1067 C CA  . LYS A 1 126 ? -20.09005 36.44500 18.72940 1.000 93.54877  ? 121 LYS A CA  1 
ATOM   1068 C C   . LYS A 1 126 ? -19.07684 37.22915 17.91150 1.000 91.09577  ? 121 LYS A C   1 
ATOM   1069 O O   . LYS A 1 126 ? -19.36143 38.33388 17.43984 1.000 90.09382  ? 121 LYS A O   1 
ATOM   1070 C CB  . LYS A 1 126 ? -21.47756 36.48703 18.09572 1.000 88.46123  ? 121 LYS A CB  1 
ATOM   1071 C CG  . LYS A 1 126 ? -22.52044 35.52165 18.69574 1.000 101.12507 ? 121 LYS A CG  1 
ATOM   1072 C CD  . LYS A 1 126 ? -21.96527 34.35117 19.53204 1.000 103.28001 ? 121 LYS A CD  1 
ATOM   1073 C CE  . LYS A 1 126 ? -20.76741 33.65400 18.88477 1.000 100.93609 ? 121 LYS A CE  1 
ATOM   1074 N NZ  . LYS A 1 126 ? -20.13978 32.64403 19.78149 1.000 89.52441  ? 121 LYS A NZ  1 
ATOM   1075 N N   . LEU A 1 127 ? -17.87237 36.68533 17.78232 1.000 87.03560  ? 122 LEU A N   1 
ATOM   1076 C CA  . LEU A 1 127 ? -16.83222 37.40109 17.06742 1.000 69.41343  ? 122 LEU A CA  1 
ATOM   1077 C C   . LEU A 1 127 ? -17.35208 37.81364 15.69648 1.000 48.89160  ? 122 LEU A C   1 
ATOM   1078 O O   . LEU A 1 127 ? -18.05404 37.05031 15.02517 1.000 58.92830  ? 122 LEU A O   1 
ATOM   1079 C CB  . LEU A 1 127 ? -15.57912 36.52297 16.95468 1.000 68.95537  ? 122 LEU A CB  1 
ATOM   1080 C CG  . LEU A 1 127 ? -15.16731 35.85470 18.28229 1.000 75.85695  ? 122 LEU A CG  1 
ATOM   1081 C CD1 . LEU A 1 127 ? -13.88580 35.05716 18.15779 1.000 64.87471  ? 122 LEU A CD1 1 
ATOM   1082 C CD2 . LEU A 1 127 ? -15.02882 36.86448 19.40834 1.000 74.98127  ? 122 LEU A CD2 1 
ATOM   1083 N N   . THR A 1 128 ? -17.05185 39.04940 15.30431 1.000 60.76993  ? 123 THR A N   1 
ATOM   1084 C CA  . THR A 1 128 ? -17.28987 39.44812 13.92571 1.000 47.75265  ? 123 THR A CA  1 
ATOM   1085 C C   . THR A 1 128 ? -16.37726 38.63711 13.00048 1.000 51.33454  ? 123 THR A C   1 
ATOM   1086 O O   . THR A 1 128 ? -15.38357 38.04710 13.43447 1.000 50.69943  ? 123 THR A O   1 
ATOM   1087 C CB  . THR A 1 128 ? -17.00281 40.93416 13.73347 1.000 55.41569  ? 123 THR A CB  1 
ATOM   1088 O OG1 . THR A 1 128 ? -15.71112 41.24126 14.25614 1.000 67.34843  ? 123 THR A OG1 1 
ATOM   1089 C CG2 . THR A 1 128 ? -18.02528 41.77402 14.50330 1.000 62.97725  ? 123 THR A CG2 1 
ATOM   1090 N N   . ASP A 1 129 ? -16.70306 38.62089 11.70627 1.000 58.86812  ? 124 ASP A N   1 
ATOM   1091 C CA  . ASP A 1 129 ? -15.80898 37.96131 10.75490 1.000 60.06602  ? 124 ASP A CA  1 
ATOM   1092 C C   . ASP A 1 129 ? -14.43266 38.61622 10.78655 1.000 55.98930  ? 124 ASP A C   1 
ATOM   1093 O O   . ASP A 1 129 ? -13.40891 37.92469 10.70889 1.000 58.82896  ? 124 ASP A O   1 
ATOM   1094 C CB  . ASP A 1 129 ? -16.37593 38.00576 9.32844  1.000 54.69227  ? 124 ASP A CB  1 
ATOM   1095 C CG  . ASP A 1 129 ? -15.59804 37.09945 8.34067  1.000 57.83290  ? 124 ASP A CG  1 
ATOM   1096 O OD1 . ASP A 1 129 ? -15.32568 35.91914 8.66465  1.000 61.99224  ? 124 ASP A OD1 1 
ATOM   1097 O OD2 . ASP A 1 129 ? -15.23220 37.55123 7.23891  1.000 47.59979  ? 124 ASP A OD2 1 
ATOM   1098 N N   . ASP A 1 130 ? -14.38516 39.95615 10.89143 1.000 50.98375  ? 125 ASP A N   1 
ATOM   1099 C CA  . ASP A 1 130 ? -13.09202 40.63642 10.94233 1.000 50.21800  ? 125 ASP A CA  1 
ATOM   1100 C C   . ASP A 1 130 ? -12.31992 40.28043 12.20038 1.000 47.08059  ? 125 ASP A C   1 
ATOM   1101 O O   . ASP A 1 130 ? -11.08536 40.23897 12.17110 1.000 48.69215  ? 125 ASP A O   1 
ATOM   1102 C CB  . ASP A 1 130 ? -13.26346 42.15228 10.82231 1.000 56.26075  ? 125 ASP A CB  1 
ATOM   1103 C CG  . ASP A 1 130 ? -14.30189 42.54139 9.77209  1.000 74.33315  ? 125 ASP A CG  1 
ATOM   1104 O OD1 . ASP A 1 130 ? -15.52208 42.41396 10.02987 1.000 76.35039  ? 125 ASP A OD1 1 
ATOM   1105 O OD2 . ASP A 1 130 ? -13.89005 42.98044 8.67307  1.000 84.50212  ? 125 ASP A OD2 1 
ATOM   1106 N N   . HIS A 1 131 ? -13.01618 40.00264 13.30102 1.000 45.02975  ? 126 HIS A N   1 
ATOM   1107 C CA  . HIS A 1 131 ? -12.33366 39.48197 14.47995 1.000 59.00939  ? 126 HIS A CA  1 
ATOM   1108 C C   . HIS A 1 131 ? -11.70832 38.11197 14.20361 1.000 47.27554  ? 126 HIS A C   1 
ATOM   1109 O O   . HIS A 1 131 ? -10.53018 37.87891 14.50987 1.000 44.51995  ? 126 HIS A O   1 
ATOM   1110 C CB  . HIS A 1 131 ? -13.31029 39.41168 15.64015 1.000 55.60875  ? 126 HIS A CB  1 
ATOM   1111 C CG  . HIS A 1 131 ? -13.66304 40.75387 16.20213 1.000 71.72834  ? 126 HIS A CG  1 
ATOM   1112 N ND1 . HIS A 1 131 ? -14.84828 40.99748 16.86108 1.000 69.88898  ? 126 HIS A ND1 1 
ATOM   1113 C CD2 . HIS A 1 131 ? -12.94618 41.90285 16.26916 1.000 72.59208  ? 126 HIS A CD2 1 
ATOM   1114 C CE1 . HIS A 1 131 ? -14.85597 42.24722 17.28914 1.000 81.22184  ? 126 HIS A CE1 1 
ATOM   1115 N NE2 . HIS A 1 131 ? -13.71507 42.81752 16.94289 1.000 78.62768  ? 126 HIS A NE2 1 
ATOM   1116 N N   . VAL A 1 132 ? -12.48002 37.19907 13.60207 1.000 38.05456  ? 127 VAL A N   1 
ATOM   1117 C CA  . VAL A 1 132 ? -11.96757 35.86474 13.29357 1.000 45.33764  ? 127 VAL A CA  1 
ATOM   1118 C C   . VAL A 1 132 ? -10.78410 35.95712 12.33568 1.000 43.75740  ? 127 VAL A C   1 
ATOM   1119 O O   . VAL A 1 132 ? -9.74519  35.30819 12.52705 1.000 39.17873  ? 127 VAL A O   1 
ATOM   1120 C CB  . VAL A 1 132 ? -13.08669 34.98156 12.71116 1.000 44.31240  ? 127 VAL A CB  1 
ATOM   1121 C CG1 . VAL A 1 132 ? -12.50101 33.61155 12.29732 1.000 41.46954  ? 127 VAL A CG1 1 
ATOM   1122 C CG2 . VAL A 1 132 ? -14.17728 34.82487 13.71418 1.000 47.22083  ? 127 VAL A CG2 1 
ATOM   1123 N N   . GLN A 1 133 ? -10.92071 36.77008 11.28753 1.000 33.90969  ? 128 GLN A N   1 
ATOM   1124 C CA  . GLN A 1 133 ? -9.80197  36.98282 10.37896 1.000 37.01229  ? 128 GLN A CA  1 
ATOM   1125 C C   . GLN A 1 133 ? -8.53375  37.36185 11.13624 1.000 44.55710  ? 128 GLN A C   1 
ATOM   1126 O O   . GLN A 1 133 ? -7.46342  36.78805 10.91085 1.000 38.12445  ? 128 GLN A O   1 
ATOM   1127 C CB  . GLN A 1 133 ? -10.13788 38.08052 9.37856  1.000 38.88740  ? 128 GLN A CB  1 
ATOM   1128 C CG  . GLN A 1 133 ? -11.20299 37.72000 8.36150  1.000 48.54005  ? 128 GLN A CG  1 
ATOM   1129 C CD  . GLN A 1 133 ? -11.34146 38.83071 7.32515  1.000 57.83333  ? 128 GLN A CD  1 
ATOM   1130 O OE1 . GLN A 1 133 ? -10.45327 39.67294 7.19504  1.000 57.45118  ? 128 GLN A OE1 1 
ATOM   1131 N NE2 . GLN A 1 133 ? -12.46519 38.86506 6.62820  1.000 56.33483  ? 128 GLN A NE2 1 
ATOM   1132 N N   . PHE A 1 134 ? -8.64136  38.34081 12.03398 1.000 39.95583  ? 129 PHE A N   1 
ATOM   1133 C CA  . PHE A 1 134 ? -7.45221  38.90632 12.65719 1.000 35.97654  ? 129 PHE A CA  1 
ATOM   1134 C C   . PHE A 1 134 ? -6.84464  37.93603 13.63722 1.000 33.77610  ? 129 PHE A C   1 
ATOM   1135 O O   . PHE A 1 134 ? -5.61977  37.81632 13.70771 1.000 36.83513  ? 129 PHE A O   1 
ATOM   1136 C CB  . PHE A 1 134 ? -7.78940  40.24345 13.32501 1.000 40.76074  ? 129 PHE A CB  1 
ATOM   1137 C CG  . PHE A 1 134 ? -6.59724  40.94092 13.96052 1.000 45.40255  ? 129 PHE A CG  1 
ATOM   1138 C CD1 . PHE A 1 134 ? -5.43029  41.15574 13.25219 1.000 51.12046  ? 129 PHE A CD1 1 
ATOM   1139 C CD2 . PHE A 1 134 ? -6.67402  41.41384 15.27147 1.000 47.36226  ? 129 PHE A CD2 1 
ATOM   1140 C CE1 . PHE A 1 134 ? -4.34346  41.80291 13.84038 1.000 50.53896  ? 129 PHE A CE1 1 
ATOM   1141 C CE2 . PHE A 1 134 ? -5.59671  42.07341 15.86908 1.000 51.20971  ? 129 PHE A CE2 1 
ATOM   1142 C CZ  . PHE A 1 134 ? -4.43049  42.27586 15.14524 1.000 48.61992  ? 129 PHE A CZ  1 
ATOM   1143 N N   . LEU A 1 135 ? -7.68519  37.20126 14.36222 1.000 32.92310  ? 130 LEU A N   1 
ATOM   1144 C CA  . LEU A 1 135 ? -7.19281  36.22332 15.32552 1.000 34.74214  ? 130 LEU A CA  1 
ATOM   1145 C C   . LEU A 1 135 ? -6.49481  35.07199 14.61920 1.000 39.03141  ? 130 LEU A C   1 
ATOM   1146 O O   . LEU A 1 135 ? -5.40560  34.65477 15.01738 1.000 32.28605  ? 130 LEU A O   1 
ATOM   1147 C CB  . LEU A 1 135 ? -8.37381  35.70360 16.15034 1.000 37.48732  ? 130 LEU A CB  1 
ATOM   1148 C CG  . LEU A 1 135 ? -8.95492  36.73488 17.14034 1.000 42.59057  ? 130 LEU A CG  1 
ATOM   1149 C CD1 . LEU A 1 135 ? -10.09884 36.14105 17.97712 1.000 39.77090  ? 130 LEU A CD1 1 
ATOM   1150 C CD2 . LEU A 1 135 ? -7.86061  37.26697 18.03612 1.000 43.11675  ? 130 LEU A CD2 1 
ATOM   1151 N N   . ILE A 1 136 ? -7.11816  34.51622 13.58363 1.000 32.25635  ? 131 ILE A N   1 
ATOM   1152 C CA  . ILE A 1 136 ? -6.48807  33.36699 12.95006 1.000 38.44675  ? 131 ILE A CA  1 
ATOM   1153 C C   . ILE A 1 136 ? -5.25550  33.83773 12.19711 1.000 33.21790  ? 131 ILE A C   1 
ATOM   1154 O O   . ILE A 1 136 ? -4.25383  33.12099 12.11485 1.000 32.57101  ? 131 ILE A O   1 
ATOM   1155 C CB  . ILE A 1 136 ? -7.49444  32.64472 12.02731 1.000 34.94240  ? 131 ILE A CB  1 
ATOM   1156 C CG1 . ILE A 1 136 ? -8.71475  32.18129 12.83215 1.000 34.81515  ? 131 ILE A CG1 1 
ATOM   1157 C CG2 . ILE A 1 136 ? -6.84252  31.45909 11.23567 1.000 32.42103  ? 131 ILE A CG2 1 
ATOM   1158 C CD1 . ILE A 1 136 ? -8.38040  31.06445 13.86797 1.000 32.38909  ? 131 ILE A CD1 1 
ATOM   1159 N N   . TYR A 1 137 ? -5.31333  35.04161 11.61292 1.000 35.43197  ? 132 TYR A N   1 
ATOM   1160 C CA  . TYR A 1 137 ? -4.13650  35.58700 10.94576 1.000 36.61185  ? 132 TYR A CA  1 
ATOM   1161 C C   . TYR A 1 137 ? -2.93684  35.56800 11.87640 1.000 38.31386  ? 132 TYR A C   1 
ATOM   1162 O O   . TYR A 1 137 ? -1.86586  35.10283 11.49777 1.000 35.14704  ? 132 TYR A O   1 
ATOM   1163 C CB  . TYR A 1 137 ? -4.39250  37.00640 10.44562 1.000 41.91432  ? 132 TYR A CB  1 
ATOM   1164 C CG  . TYR A 1 137 ? -3.11748  37.65538 9.93968  1.000 46.23617  ? 132 TYR A CG  1 
ATOM   1165 C CD1 . TYR A 1 137 ? -2.61583  37.33852 8.68929  1.000 35.27612  ? 132 TYR A CD1 1 
ATOM   1166 C CD2 . TYR A 1 137 ? -2.40332  38.54260 10.73329 1.000 34.01389  ? 132 TYR A CD2 1 
ATOM   1167 C CE1 . TYR A 1 137 ? -1.43239  37.89781 8.21757  1.000 41.01754  ? 132 TYR A CE1 1 
ATOM   1168 C CE2 . TYR A 1 137 ? -1.18383  39.12599 10.27688 1.000 38.17656  ? 132 TYR A CE2 1 
ATOM   1169 C CZ  . TYR A 1 137 ? -0.71797  38.79193 9.00517  1.000 40.99478  ? 132 TYR A CZ  1 
ATOM   1170 O OH  . TYR A 1 137 ? 0.47164   39.33695 8.51195  1.000 51.64514  ? 132 TYR A OH  1 
ATOM   1171 N N   . GLN A 1 138 ? -3.10822  36.03159 13.11764 1.000 34.54159  ? 133 GLN A N   1 
ATOM   1172 C CA  . GLN A 1 138 ? -1.98478  36.08433 14.04855 1.000 31.56069  ? 133 GLN A CA  1 
ATOM   1173 C C   . GLN A 1 138 ? -1.49471  34.68978 14.42954 1.000 31.98643  ? 133 GLN A C   1 
ATOM   1174 O O   . GLN A 1 138 ? -0.28269  34.47529 14.57394 1.000 34.81618  ? 133 GLN A O   1 
ATOM   1175 C CB  . GLN A 1 138 ? -2.39317  36.86513 15.29996 1.000 32.00998  ? 133 GLN A CB  1 
ATOM   1176 C CG  . GLN A 1 138 ? -2.71686  38.30654 15.03658 1.000 36.64129  ? 133 GLN A CG  1 
ATOM   1177 C CD  . GLN A 1 138 ? -3.19954  38.96835 16.28237 1.000 38.11154  ? 133 GLN A CD  1 
ATOM   1178 O OE1 . GLN A 1 138 ? -2.42502  39.48077 17.07074 1.000 39.06920  ? 133 GLN A OE1 1 
ATOM   1179 N NE2 . GLN A 1 138 ? -4.49867  38.92592 16.48901 1.000 36.89984  ? 133 GLN A NE2 1 
ATOM   1180 N N   . ILE A 1 139 ? -2.42068  33.74227 14.65224 1.000 32.46129  ? 134 ILE A N   1 
ATOM   1181 C CA  . ILE A 1 139 ? -2.00444  32.36790 14.93312 1.000 36.30823  ? 134 ILE A CA  1 
ATOM   1182 C C   . ILE A 1 139 ? -1.11842  31.84152 13.81277 1.000 36.85500  ? 134 ILE A C   1 
ATOM   1183 O O   . ILE A 1 139 ? -0.09103  31.21069 14.06439 1.000 31.44477  ? 134 ILE A O   1 
ATOM   1184 C CB  . ILE A 1 139 ? -3.21652  31.45150 15.13585 1.000 32.78036  ? 134 ILE A CB  1 
ATOM   1185 C CG1 . ILE A 1 139 ? -4.09862  31.96774 16.25167 1.000 33.11424  ? 134 ILE A CG1 1 
ATOM   1186 C CG2 . ILE A 1 139 ? -2.73167  29.99169 15.40010 1.000 34.41077  ? 134 ILE A CG2 1 
ATOM   1187 C CD1 . ILE A 1 139 ? -5.41190  31.17187 16.32781 1.000 40.74522  ? 134 ILE A CD1 1 
ATOM   1188 N N   . LEU A 1 140 ? -1.53294  32.04151 12.56197 1.000 35.78660  ? 135 LEU A N   1 
ATOM   1189 C CA  . LEU A 1 140 ? -0.76581  31.50622 11.42795 1.000 37.08460  ? 135 LEU A CA  1 
ATOM   1190 C C   . LEU A 1 140 ? 0.55651   32.24406 11.26331 1.000 30.84287  ? 135 LEU A C   1 
ATOM   1191 O O   . LEU A 1 140 ? 1.56530   31.64990 10.85262 1.000 30.94562  ? 135 LEU A O   1 
ATOM   1192 C CB  . LEU A 1 140 ? -1.60823  31.63296 10.15330 1.000 35.33275  ? 135 LEU A CB  1 
ATOM   1193 C CG  . LEU A 1 140 ? -2.82724  30.70934 10.04190 1.000 34.89033  ? 135 LEU A CG  1 
ATOM   1194 C CD1 . LEU A 1 140 ? -3.61564  31.03670 8.75614  1.000 42.49546  ? 135 LEU A CD1 1 
ATOM   1195 C CD2 . LEU A 1 140 ? -2.40564  29.23548 10.02655 1.000 39.10461  ? 135 LEU A CD2 1 
ATOM   1196 N N   . ARG A 1 141 ? 0.56635   33.54017 11.59829 1.000 32.84764  ? 136 ARG A N   1 
ATOM   1197 C CA  . ARG A 1 141 ? 1.80501   34.30950 11.61767 1.000 35.12000  ? 136 ARG A CA  1 
ATOM   1198 C C   . ARG A 1 141 ? 2.78054   33.74221 12.63177 1.000 33.44716  ? 136 ARG A C   1 
ATOM   1199 O O   . ARG A 1 141 ? 3.97372   33.58267 12.34289 1.000 33.86129  ? 136 ARG A O   1 
ATOM   1200 C CB  . ARG A 1 141 ? 1.48309   35.77783 11.90616 1.000 35.24228  ? 136 ARG A CB  1 
ATOM   1201 C CG  . ARG A 1 141 ? 2.61520   36.75351 11.59259 1.000 49.91738  ? 136 ARG A CG  1 
ATOM   1202 C CD  . ARG A 1 141 ? 2.11012   38.20206 11.66792 1.000 44.41678  ? 136 ARG A CD  1 
ATOM   1203 N NE  . ARG A 1 141 ? 3.21145   39.15619 11.62277 1.000 42.77250  ? 136 ARG A NE  1 
ATOM   1204 C CZ  . ARG A 1 141 ? 3.87122   39.59929 12.68482 1.000 48.52184  ? 136 ARG A CZ  1 
ATOM   1205 N NH1 . ARG A 1 141 ? 3.53781   39.22455 13.91304 1.000 57.67049  ? 136 ARG A NH1 1 
ATOM   1206 N NH2 . ARG A 1 141 ? 4.84774   40.48676 12.51707 1.000 51.92314  ? 136 ARG A NH2 1 
ATOM   1207 N N   . GLY A 1 142 ? 2.29695   33.44465 13.83737 1.000 37.34317  ? 137 GLY A N   1 
ATOM   1208 C CA  . GLY A 1 142 ? 3.16243   32.81697 14.81915 1.000 35.15059  ? 137 GLY A CA  1 
ATOM   1209 C C   . GLY A 1 142 ? 3.56897   31.41912 14.39698 1.000 37.92387  ? 137 GLY A C   1 
ATOM   1210 O O   . GLY A 1 142 ? 4.70410   31.00590 14.61551 1.000 31.24649  ? 137 GLY A O   1 
ATOM   1211 N N   . LEU A 1 143 ? 2.65142   30.68218 13.76107 1.000 39.53011  ? 138 LEU A N   1 
ATOM   1212 C CA  . LEU A 1 143 ? 2.92476   29.31166 13.34042 1.000 43.88614  ? 138 LEU A CA  1 
ATOM   1213 C C   . LEU A 1 143 ? 3.91769   29.29519 12.18190 1.000 35.36773  ? 138 LEU A C   1 
ATOM   1214 O O   . LEU A 1 143 ? 4.79246   28.42769 12.12395 1.000 35.74837  ? 138 LEU A O   1 
ATOM   1215 C CB  . LEU A 1 143 ? 1.59203   28.67768 12.94377 1.000 40.07608  ? 138 LEU A CB  1 
ATOM   1216 C CG  . LEU A 1 143 ? 0.91782   27.74715 13.93161 1.000 39.00853  ? 138 LEU A CG  1 
ATOM   1217 C CD1 . LEU A 1 143 ? -0.17130  26.87038 13.22028 1.000 33.52604  ? 138 LEU A CD1 1 
ATOM   1218 C CD2 . LEU A 1 143 ? 1.94407   26.90318 14.71513 1.000 32.74295  ? 138 LEU A CD2 1 
ATOM   1219 N N   . LYS A 1 144 ? 3.80158   30.24989 11.24392 1.000 33.00862  ? 139 LYS A N   1 
ATOM   1220 C CA  . LYS A 1 144 ? 4.80260   30.32821 10.18689 1.000 35.51814  ? 139 LYS A CA  1 
ATOM   1221 C C   . LYS A 1 144 ? 6.19419   30.46377 10.79704 1.000 46.13043  ? 139 LYS A C   1 
ATOM   1222 O O   . LYS A 1 144 ? 7.13736   29.78126 10.36725 1.000 36.27833  ? 139 LYS A O   1 
ATOM   1223 C CB  . LYS A 1 144 ? 4.52545   31.49183 9.23354  1.000 33.46914  ? 139 LYS A CB  1 
ATOM   1224 C CG  . LYS A 1 144 ? 5.63447   31.67057 8.21390  1.000 36.05234  ? 139 LYS A CG  1 
ATOM   1225 C CD  . LYS A 1 144 ? 5.68471   33.04993 7.57824  1.000 39.32229  ? 139 LYS A CD  1 
ATOM   1226 C CE  . LYS A 1 144 ? 6.59473   33.03072 6.33521  1.000 47.04809  ? 139 LYS A CE  1 
ATOM   1227 N NZ  . LYS A 1 144 ? 6.81357   34.38612 5.75687  1.000 42.90972  ? 139 LYS A NZ  1 
ATOM   1228 N N   . TYR A 1 145 ? 6.32845   31.30744 11.83330 1.000 32.48496  ? 140 TYR A N   1 
ATOM   1229 C CA  . TYR A 1 145 ? 7.60896   31.48494 12.52595 1.000 31.87738  ? 140 TYR A CA  1 
ATOM   1230 C C   . TYR A 1 145 ? 8.04875   30.20549 13.20243 1.000 33.41799  ? 140 TYR A C   1 
ATOM   1231 O O   . TYR A 1 145 ? 9.20174   29.77192 13.06480 1.000 35.79229  ? 140 TYR A O   1 
ATOM   1232 C CB  . TYR A 1 145 ? 7.47521   32.61862 13.55273 1.000 33.99719  ? 140 TYR A CB  1 
ATOM   1233 C CG  . TYR A 1 145 ? 8.64202   32.84922 14.44173 1.000 34.06640  ? 140 TYR A CG  1 
ATOM   1234 C CD1 . TYR A 1 145 ? 9.68766   33.69546 14.06216 1.000 34.27433  ? 140 TYR A CD1 1 
ATOM   1235 C CD2 . TYR A 1 145 ? 8.70748   32.21493 15.67122 1.000 35.50531  ? 140 TYR A CD2 1 
ATOM   1236 C CE1 . TYR A 1 145 ? 10.76608  33.90451 14.89289 1.000 41.72623  ? 140 TYR A CE1 1 
ATOM   1237 C CE2 . TYR A 1 145 ? 9.78408   32.40833 16.50314 1.000 38.05368  ? 140 TYR A CE2 1 
ATOM   1238 C CZ  . TYR A 1 145 ? 10.80911  33.25397 16.09690 1.000 39.67463  ? 140 TYR A CZ  1 
ATOM   1239 O OH  . TYR A 1 145 ? 11.86423  33.44907 16.92551 1.000 38.51029  ? 140 TYR A OH  1 
ATOM   1240 N N   . ILE A 1 146 ? 7.14795   29.60661 13.97898 1.000 31.26462  ? 141 ILE A N   1 
ATOM   1241 C CA  . ILE A 1 146 ? 7.50672   28.42329 14.75998 1.000 33.75343  ? 141 ILE A CA  1 
ATOM   1242 C C   . ILE A 1 146 ? 7.95390   27.30395 13.83239 1.000 38.20847  ? 141 ILE A C   1 
ATOM   1243 O O   . ILE A 1 146 ? 9.00369   26.66853 14.03702 1.000 32.39682  ? 141 ILE A O   1 
ATOM   1244 C CB  . ILE A 1 146 ? 6.32285   27.99092 15.64192 1.000 42.94731  ? 141 ILE A CB  1 
ATOM   1245 C CG1 . ILE A 1 146 ? 6.18624   28.96915 16.81847 1.000 48.14806  ? 141 ILE A CG1 1 
ATOM   1246 C CG2 . ILE A 1 146 ? 6.53780   26.58414 16.18702 1.000 44.37686  ? 141 ILE A CG2 1 
ATOM   1247 C CD1 . ILE A 1 146 ? 4.75143   29.07107 17.32895 1.000 43.77664  ? 141 ILE A CD1 1 
ATOM   1248 N N   . HIS A 1 147 ? 7.18440   27.08860 12.76100 1.000 29.05480  ? 142 HIS A N   1 
ATOM   1249 C CA  . HIS A 1 147 ? 7.46467   26.00168 11.83093 1.000 33.34623  ? 142 HIS A CA  1 
ATOM   1250 C C   . HIS A 1 147 ? 8.74623   26.24082 11.02852 1.000 33.50159  ? 142 HIS A C   1 
ATOM   1251 O O   . HIS A 1 147 ? 9.38717   25.28114 10.58225 1.000 35.40998  ? 142 HIS A O   1 
ATOM   1252 C CB  . HIS A 1 147 ? 6.25809   25.81476 10.90031 1.000 32.17761  ? 142 HIS A CB  1 
ATOM   1253 C CG  . HIS A 1 147 ? 5.07015   25.21327 11.57556 1.000 30.33753  ? 142 HIS A CG  1 
ATOM   1254 N ND1 . HIS A 1 147 ? 3.86177   25.03485 10.93901 1.000 36.89009  ? 142 HIS A ND1 1 
ATOM   1255 C CD2 . HIS A 1 147 ? 4.88915   24.76877 12.84709 1.000 37.18765  ? 142 HIS A CD2 1 
ATOM   1256 C CE1 . HIS A 1 147 ? 2.99632   24.48516 11.77314 1.000 34.84703  ? 142 HIS A CE1 1 
ATOM   1257 N NE2 . HIS A 1 147 ? 3.58608   24.32837 12.94236 1.000 38.39102  ? 142 HIS A NE2 1 
ATOM   1258 N N   . SER A 1 148 ? 9.09737   27.49880 10.77888 1.000 35.12464  ? 143 SER A N   1 
ATOM   1259 C CA  . SER A 1 148 ? 10.32840  27.79737 10.06540 1.000 34.65637  ? 143 SER A CA  1 
ATOM   1260 C C   . SER A 1 148 ? 11.56482  27.40421 10.84912 1.000 42.49843  ? 143 SER A C   1 
ATOM   1261 O O   . SER A 1 148 ? 12.61305  27.21568 10.23500 1.000 43.35435  ? 143 SER A O   1 
ATOM   1262 C CB  . SER A 1 148 ? 10.33301  29.27341 9.69041  1.000 44.12128  ? 143 SER A CB  1 
ATOM   1263 O OG  . SER A 1 148 ? 10.63954  30.06909 10.81096 1.000 39.12005  ? 143 SER A OG  1 
ATOM   1264 N N   . ALA A 1 149 ? 11.44433  27.20933 12.16385 1.000 36.37805  ? 144 ALA A N   1 
ATOM   1265 C CA  . ALA A 1 149 ? 12.48637  26.66469 13.01754 1.000 42.28823  ? 144 ALA A CA  1 
ATOM   1266 C C   . ALA A 1 149 ? 12.37672  25.14638 13.15910 1.000 43.92005  ? 144 ALA A C   1 
ATOM   1267 O O   . ALA A 1 149 ? 13.09020  24.56279 13.97485 1.000 45.24979  ? 144 ALA A O   1 
ATOM   1268 C CB  . ALA A 1 149 ? 12.41435  27.33141 14.40313 1.000 41.80897  ? 144 ALA A CB  1 
ATOM   1269 N N   . ASP A 1 150 ? 11.48858  24.49747 12.39074 1.000 40.54875  ? 145 ASP A N   1 
ATOM   1270 C CA  . ASP A 1 150 ? 11.15908  23.07700 12.58232 1.000 35.30228  ? 145 ASP A CA  1 
ATOM   1271 C C   . ASP A 1 150 ? 10.75501  22.75040 14.02684 1.000 51.11471  ? 145 ASP A C   1 
ATOM   1272 O O   . ASP A 1 150 ? 11.01710  21.65757 14.54593 1.000 42.93465  ? 145 ASP A O   1 
ATOM   1273 C CB  . ASP A 1 150 ? 12.31449  22.19621 12.10118 1.000 47.24404  ? 145 ASP A CB  1 
ATOM   1274 C CG  . ASP A 1 150 ? 12.48440  22.26163 10.57576 1.000 77.20237  ? 145 ASP A CG  1 
ATOM   1275 O OD1 . ASP A 1 150 ? 11.44947  22.25512 9.85067  1.000 65.40799  ? 145 ASP A OD1 1 
ATOM   1276 O OD2 . ASP A 1 150 ? 13.64211  22.34123 10.09927 1.000 93.81789  ? 145 ASP A OD2 1 
ATOM   1277 N N   . ILE A 1 151 ? 10.07363  23.68705 14.67947 1.000 38.36500  ? 146 ILE A N   1 
ATOM   1278 C CA  . ILE A 1 151 ? 9.38509   23.42336 15.93530 1.000 39.79469  ? 146 ILE A CA  1 
ATOM   1279 C C   . ILE A 1 151 ? 7.92967   23.08490 15.63543 1.000 39.87469  ? 146 ILE A C   1 
ATOM   1280 O O   . ILE A 1 151 ? 7.28815   23.73412 14.80820 1.000 37.91341  ? 146 ILE A O   1 
ATOM   1281 C CB  . ILE A 1 151 ? 9.48189   24.63503 16.88145 1.000 42.19712  ? 146 ILE A CB  1 
ATOM   1282 C CG1 . ILE A 1 151 ? 10.94224  24.86229 17.29066 1.000 41.72727  ? 146 ILE A CG1 1 
ATOM   1283 C CG2 . ILE A 1 151 ? 8.56797   24.42481 18.09331 1.000 43.01351  ? 146 ILE A CG2 1 
ATOM   1284 C CD1 . ILE A 1 151 ? 11.21993  26.25819 17.75257 1.000 43.08534  ? 146 ILE A CD1 1 
ATOM   1285 N N   . ILE A 1 152 ? 7.40590   22.05881 16.28811 1.000 38.73596  ? 147 ILE A N   1 
ATOM   1286 C CA  . ILE A 1 152 ? 5.98448   21.73778 16.22284 1.000 35.94867  ? 147 ILE A CA  1 
ATOM   1287 C C   . ILE A 1 152 ? 5.38090   22.06938 17.58029 1.000 39.58318  ? 147 ILE A C   1 
ATOM   1288 O O   . ILE A 1 152 ? 5.87446   21.61108 18.60988 1.000 41.95787  ? 147 ILE A O   1 
ATOM   1289 C CB  . ILE A 1 152 ? 5.76424   20.26051 15.85227 1.000 36.50848  ? 147 ILE A CB  1 
ATOM   1290 C CG1 . ILE A 1 152 ? 6.62094   19.87937 14.64366 1.000 49.76275  ? 147 ILE A CG1 1 
ATOM   1291 C CG2 . ILE A 1 152 ? 4.24703   19.93015 15.63655 1.000 33.69680  ? 147 ILE A CG2 1 
ATOM   1292 C CD1 . ILE A 1 152 ? 6.49144   18.45018 14.24016 1.000 43.74421  ? 147 ILE A CD1 1 
ATOM   1293 N N   . HIS A 1 153 ? 4.30534   22.85041 17.59337 1.000 42.00055  ? 148 HIS A N   1 
ATOM   1294 C CA  . HIS A 1 153 ? 3.66114   23.09445 18.87341 1.000 30.14285  ? 148 HIS A CA  1 
ATOM   1295 C C   . HIS A 1 153 ? 3.05662   21.81847 19.42485 1.000 36.74213  ? 148 HIS A C   1 
ATOM   1296 O O   . HIS A 1 153 ? 3.29574   21.46625 20.58019 1.000 43.11755  ? 148 HIS A O   1 
ATOM   1297 C CB  . HIS A 1 153 ? 2.59690   24.18821 18.73441 1.000 42.10109  ? 148 HIS A CB  1 
ATOM   1298 C CG  . HIS A 1 153 ? 2.06903   24.66875 20.04865 1.000 36.91983  ? 148 HIS A CG  1 
ATOM   1299 N ND1 . HIS A 1 153 ? 1.13145   23.96796 20.77578 1.000 38.73143  ? 148 HIS A ND1 1 
ATOM   1300 C CD2 . HIS A 1 153 ? 2.40011   25.74771 20.79637 1.000 41.23409  ? 148 HIS A CD2 1 
ATOM   1301 C CE1 . HIS A 1 153 ? 0.88273   24.61614 21.90178 1.000 43.53248  ? 148 HIS A CE1 1 
ATOM   1302 N NE2 . HIS A 1 153 ? 1.64958   25.69235 21.94200 1.000 38.20412  ? 148 HIS A NE2 1 
ATOM   1303 N N   . ARG A 1 154 ? 2.21775   21.14158 18.63216 1.000 37.19460  ? 149 ARG A N   1 
ATOM   1304 C CA  . ARG A 1 154 ? 1.63252   19.83086 18.88245 1.000 40.76331  ? 149 ARG A CA  1 
ATOM   1305 C C   . ARG A 1 154 ? 0.43737   19.93434 19.83199 1.000 45.95753  ? 149 ARG A C   1 
ATOM   1306 O O   . ARG A 1 154 ? -0.25957  18.93165 20.03024 1.000 52.00403  ? 149 ARG A O   1 
ATOM   1307 C CB  . ARG A 1 154 ? 2.64548   18.82802 19.47618 1.000 47.90222  ? 149 ARG A CB  1 
ATOM   1308 C CG  . ARG A 1 154 ? 3.99719   18.75755 18.76317 1.000 57.71163  ? 149 ARG A CG  1 
ATOM   1309 C CD  . ARG A 1 154 ? 5.03784   17.98304 19.63285 1.000 70.81608  ? 149 ARG A CD  1 
ATOM   1310 N NE  . ARG A 1 154 ? 6.41324   18.24465 19.20505 1.000 65.95341  ? 149 ARG A NE  1 
ATOM   1311 C CZ  . ARG A 1 154 ? 7.18688   17.38839 18.54878 1.000 74.20180  ? 149 ARG A CZ  1 
ATOM   1312 N NH1 . ARG A 1 154 ? 6.80860   16.14216 18.33273 1.000 76.08826  ? 149 ARG A NH1 1 
ATOM   1313 N NH2 . ARG A 1 154 ? 8.38532   17.78666 18.12453 1.000 62.55443  ? 149 ARG A NH2 1 
ATOM   1314 N N   . ASP A 1 155 ? 0.18111   21.10405 20.44630 1.000 44.74370  ? 150 ASP A N   1 
ATOM   1315 C CA  . ASP A 1 155 ? -0.86312  21.18589 21.45946 1.000 48.79172  ? 150 ASP A CA  1 
ATOM   1316 C C   . ASP A 1 155 ? -1.66524  22.47362 21.32985 1.000 45.81112  ? 150 ASP A C   1 
ATOM   1317 O O   . ASP A 1 155 ? -2.08443  23.05629 22.32871 1.000 38.09002  ? 150 ASP A O   1 
ATOM   1318 C CB  . ASP A 1 155 ? -0.22788  21.05651 22.84776 1.000 57.33022  ? 150 ASP A CB  1 
ATOM   1319 C CG  . ASP A 1 155 ? -1.24674  20.96079 23.95646 1.000 75.29979  ? 150 ASP A CG  1 
ATOM   1320 O OD1 . ASP A 1 155 ? -1.18256  21.81094 24.87871 1.000 66.10487  ? 150 ASP A OD1 1 
ATOM   1321 O OD2 . ASP A 1 155 ? -2.12609  20.05741 23.87724 1.000 65.80231  ? 150 ASP A OD2 1 
ATOM   1322 N N   A LEU A 1 156 ? -1.84428  22.95709 20.11065 0.520 38.62811  ? 151 LEU A N   1 
ATOM   1323 N N   B LEU A 1 156 ? -1.90347  22.93094 20.10817 0.480 38.60452  ? 151 LEU A N   1 
ATOM   1324 C CA  A LEU A 1 156 ? -2.62021  24.16494 19.90236 0.520 40.49210  ? 151 LEU A CA  1 
ATOM   1325 C CA  B LEU A 1 156 ? -2.59033  24.19827 19.90727 0.480 40.49652  ? 151 LEU A CA  1 
ATOM   1326 C C   A LEU A 1 156 ? -4.06928  23.93537 20.29780 0.520 38.41739  ? 151 LEU A C   1 
ATOM   1327 C C   B LEU A 1 156 ? -4.07494  24.01832 20.21994 0.480 38.40599  ? 151 LEU A C   1 
ATOM   1328 O O   A LEU A 1 156 ? -4.70666  22.97427 19.84853 0.520 33.98623  ? 151 LEU A O   1 
ATOM   1329 O O   B LEU A 1 156 ? -4.74568  23.15677 19.63700 0.480 34.44126  ? 151 LEU A O   1 
ATOM   1330 C CB  A LEU A 1 156 ? -2.51996  24.59015 18.44184 0.520 36.09381  ? 151 LEU A CB  1 
ATOM   1331 C CB  B LEU A 1 156 ? -2.38948  24.65593 18.46660 0.480 35.92565  ? 151 LEU A CB  1 
ATOM   1332 C CG  A LEU A 1 156 ? -2.41838  26.05856 18.07780 0.520 43.96132  ? 151 LEU A CG  1 
ATOM   1333 C CG  B LEU A 1 156 ? -1.05161  25.25271 18.02485 0.480 42.16896  ? 151 LEU A CG  1 
ATOM   1334 C CD1 A LEU A 1 156 ? -1.47277  26.82959 18.98460 0.520 37.50743  ? 151 LEU A CD1 1 
ATOM   1335 C CD1 B LEU A 1 156 ? -1.13708  25.61303 16.57007 0.480 30.98282  ? 151 LEU A CD1 1 
ATOM   1336 C CD2 A LEU A 1 156 ? -1.97988  26.14643 16.63817 0.520 34.89849  ? 151 LEU A CD2 1 
ATOM   1337 C CD2 B LEU A 1 156 ? -0.61504  26.47116 18.84537 0.480 39.37589  ? 151 LEU A CD2 1 
ATOM   1338 N N   . LYS A 1 157 ? -4.58308  24.81255 21.15179 1.000 32.85139  ? 152 LYS A N   1 
ATOM   1339 C CA  . LYS A 1 157 ? -6.00495  24.81818 21.47510 1.000 37.93485  ? 152 LYS A CA  1 
ATOM   1340 C C   . LYS A 1 157 ? -6.33811  26.19188 22.03531 1.000 37.47331  ? 152 LYS A C   1 
ATOM   1341 O O   . LYS A 1 157 ? -5.42959  26.98507 22.32077 1.000 36.10878  ? 152 LYS A O   1 
ATOM   1342 C CB  . LYS A 1 157 ? -6.36350  23.70811 22.47106 1.000 40.28377  ? 152 LYS A CB  1 
ATOM   1343 C CG  . LYS A 1 157 ? -5.55760  23.68868 23.74090 1.000 48.01822  ? 152 LYS A CG  1 
ATOM   1344 C CD  . LYS A 1 157 ? -6.14047  22.66916 24.71930 1.000 52.42999  ? 152 LYS A CD  1 
ATOM   1345 C CE  . LYS A 1 157 ? -5.07794  22.07907 25.58412 1.000 54.47462  ? 152 LYS A CE  1 
ATOM   1346 N NZ  . LYS A 1 157 ? -4.21377  21.24777 24.72245 1.000 67.42466  ? 152 LYS A NZ  1 
ATOM   1347 N N   . PRO A 1 158 ? -7.63638  26.51909 22.19292 1.000 36.73610  ? 153 PRO A N   1 
ATOM   1348 C CA  . PRO A 1 158 ? -7.97477  27.88370 22.65149 1.000 36.14547  ? 153 PRO A CA  1 
ATOM   1349 C C   . PRO A 1 158 ? -7.28683  28.28214 23.94300 1.000 37.88905  ? 153 PRO A C   1 
ATOM   1350 O O   . PRO A 1 158 ? -6.85924  29.43761 24.06071 1.000 38.61064  ? 153 PRO A O   1 
ATOM   1351 C CB  . PRO A 1 158 ? -9.50881  27.85428 22.77318 1.000 38.57207  ? 153 PRO A CB  1 
ATOM   1352 C CG  . PRO A 1 158 ? -9.92420  26.89046 21.67404 1.000 37.83828  ? 153 PRO A CG  1 
ATOM   1353 C CD  . PRO A 1 158 ? -8.81841  25.81072 21.66987 1.000 32.34748  ? 153 PRO A CD  1 
ATOM   1354 N N   . SER A 1 159 ? -7.13607  27.36089 24.89994 1.000 36.18253  ? 154 SER A N   1 
ATOM   1355 C CA  . SER A 1 159 ? -6.55594  27.73592 26.18258 1.000 45.20258  ? 154 SER A CA  1 
ATOM   1356 C C   . SER A 1 159 ? -5.07704  28.07112 26.06765 1.000 50.24610  ? 154 SER A C   1 
ATOM   1357 O O   . SER A 1 159 ? -4.51737  28.64795 27.00402 1.000 46.30730  ? 154 SER A O   1 
ATOM   1358 C CB  . SER A 1 159 ? -6.74143  26.61332 27.22060 1.000 43.77216  ? 154 SER A CB  1 
ATOM   1359 O OG  . SER A 1 159 ? -6.26519  25.36573 26.73426 1.000 46.70876  ? 154 SER A OG  1 
ATOM   1360 N N   . ASN A 1 160 ? -4.43911  27.71511 24.95198 1.000 39.11571  ? 155 ASN A N   1 
ATOM   1361 C CA  . ASN A 1 160 ? -3.03818  28.00331 24.67534 1.000 42.34778  ? 155 ASN A CA  1 
ATOM   1362 C C   . ASN A 1 160 ? -2.83345  29.27926 23.89065 1.000 36.59075  ? 155 ASN A C   1 
ATOM   1363 O O   . ASN A 1 160 ? -1.72383  29.49223 23.38179 1.000 36.73471  ? 155 ASN A O   1 
ATOM   1364 C CB  . ASN A 1 160 ? -2.35919  26.84974 23.90431 1.000 41.41854  ? 155 ASN A CB  1 
ATOM   1365 C CG  . ASN A 1 160 ? -2.25785  25.58926 24.69732 1.000 56.92745  ? 155 ASN A CG  1 
ATOM   1366 O OD1 . ASN A 1 160 ? -1.85390  25.60943 25.86025 1.000 63.27236  ? 155 ASN A OD1 1 
ATOM   1367 N ND2 . ASN A 1 160 ? -2.52682  24.47586 24.05948 1.000 52.45446  ? 155 ASN A ND2 1 
ATOM   1368 N N   . LEU A 1 161 ? -3.86740  30.11686 23.76774 1.000 41.56295  ? 156 LEU A N   1 
ATOM   1369 C CA  . LEU A 1 161 ? -3.81307  31.34373 22.98057 1.000 39.28162  ? 156 LEU A CA  1 
ATOM   1370 C C   . LEU A 1 161 ? -4.23239  32.50150 23.87640 1.000 46.58326  ? 156 LEU A C   1 
ATOM   1371 O O   . LEU A 1 161 ? -5.38445  32.56252 24.31958 1.000 44.30120  ? 156 LEU A O   1 
ATOM   1372 C CB  . LEU A 1 161 ? -4.69942  31.23712 21.73692 1.000 37.71955  ? 156 LEU A CB  1 
ATOM   1373 C CG  . LEU A 1 161 ? -4.36369  30.02055 20.87029 1.000 33.88555  ? 156 LEU A CG  1 
ATOM   1374 C CD1 . LEU A 1 161 ? -5.49462  29.74355 19.87726 1.000 34.49279  ? 156 LEU A CD1 1 
ATOM   1375 C CD2 . LEU A 1 161 ? -3.03545  30.30391 20.18066 1.000 37.30458  ? 156 LEU A CD2 1 
ATOM   1376 N N   . ALA A 1 162 ? -3.28922  33.40530 24.14880 1.000 45.20907  ? 157 ALA A N   1 
ATOM   1377 C CA  . ALA A 1 162 ? -3.54081  34.61486 24.92434 1.000 42.20375  ? 157 ALA A CA  1 
ATOM   1378 C C   . ALA A 1 162 ? -3.99364  35.72557 23.99227 1.000 45.44018  ? 157 ALA A C   1 
ATOM   1379 O O   . ALA A 1 162 ? -3.45348  35.88306 22.89447 1.000 38.86521  ? 157 ALA A O   1 
ATOM   1380 C CB  . ALA A 1 162 ? -2.27816  35.06035 25.66482 1.000 45.31729  ? 157 ALA A CB  1 
ATOM   1381 N N   . VAL A 1 163 ? -5.00859  36.47468 24.42066 1.000 45.62690  ? 158 VAL A N   1 
ATOM   1382 C CA  . VAL A 1 163 ? -5.60641  37.53748 23.61528 1.000 49.05027  ? 158 VAL A CA  1 
ATOM   1383 C C   . VAL A 1 163 ? -5.85835  38.71955 24.54703 1.000 54.37728  ? 158 VAL A C   1 
ATOM   1384 O O   . VAL A 1 163 ? -6.69955  38.63182 25.44704 1.000 60.87107  ? 158 VAL A O   1 
ATOM   1385 C CB  . VAL A 1 163 ? -6.91421  37.09573 22.94033 1.000 50.27352  ? 158 VAL A CB  1 
ATOM   1386 C CG1 . VAL A 1 163 ? -7.61154  38.28106 22.27124 1.000 56.79831  ? 158 VAL A CG1 1 
ATOM   1387 C CG2 . VAL A 1 163 ? -6.65334  35.97141 21.92981 1.000 47.87096  ? 158 VAL A CG2 1 
ATOM   1388 N N   . ASN A 1 164 ? -5.14353  39.81687 24.33547 1.000 51.90263  ? 159 ASN A N   1 
ATOM   1389 C CA  . ASN A 1 164 ? -5.33858  41.00084 25.15941 1.000 56.50205  ? 159 ASN A CA  1 
ATOM   1390 C C   . ASN A 1 164 ? -6.56459  41.77483 24.64733 1.000 67.79840  ? 159 ASN A C   1 
ATOM   1391 O O   . ASN A 1 164 ? -7.34055  41.30439 23.80743 1.000 51.81232  ? 159 ASN A O   1 
ATOM   1392 C CB  . ASN A 1 164 ? -4.04440  41.81788 25.20312 1.000 49.15872  ? 159 ASN A CB  1 
ATOM   1393 C CG  . ASN A 1 164 ? -3.78099  42.59793 23.92749 1.000 50.74158  ? 159 ASN A CG  1 
ATOM   1394 O OD1 . ASN A 1 164 ? -4.67082  42.78384 23.08962 1.000 58.70646  ? 159 ASN A OD1 1 
ATOM   1395 N ND2 . ASN A 1 164 ? -2.53381  43.04313 23.76279 1.000 62.69580  ? 159 ASN A ND2 1 
ATOM   1396 N N   . GLU A 1 165 ? -6.76637  42.97675 25.17472 1.000 70.50495  ? 160 GLU A N   1 
ATOM   1397 C CA  . GLU A 1 165 ? -7.97913  43.73041 24.90240 1.000 62.02615  ? 160 GLU A CA  1 
ATOM   1398 C C   . GLU A 1 165 ? -7.97516  44.36141 23.51796 1.000 75.25108  ? 160 GLU A C   1 
ATOM   1399 O O   . GLU A 1 165 ? -9.04887  44.66291 22.98378 1.000 73.21051  ? 160 GLU A O   1 
ATOM   1400 C CB  . GLU A 1 165 ? -8.17875  44.81657 25.96380 1.000 68.51090  ? 160 GLU A CB  1 
ATOM   1401 C CG  . GLU A 1 165 ? -7.85575  44.42390 27.42510 1.000 90.63589  ? 160 GLU A CG  1 
ATOM   1402 C CD  . GLU A 1 165 ? -6.42668  43.90942 27.65000 1.000 91.89775  ? 160 GLU A CD  1 
ATOM   1403 O OE1 . GLU A 1 165 ? -5.48524  44.47011 27.04626 1.000 85.70549  ? 160 GLU A OE1 1 
ATOM   1404 O OE2 . GLU A 1 165 ? -6.23873  42.95142 28.43246 1.000 92.74560  ? 160 GLU A OE2 1 
ATOM   1405 N N   . ASP A 1 166 ? -6.79584  44.58111 22.93781 1.000 67.36975  ? 161 ASP A N   1 
ATOM   1406 C CA  . ASP A 1 166 ? -6.67608  45.06358 21.57058 1.000 58.99738  ? 161 ASP A CA  1 
ATOM   1407 C C   . ASP A 1 166 ? -6.74327  43.92899 20.54519 1.000 73.42502  ? 161 ASP A C   1 
ATOM   1408 O O   . ASP A 1 166 ? -6.45346  44.15500 19.36067 1.000 61.51432  ? 161 ASP A O   1 
ATOM   1409 C CB  . ASP A 1 166 ? -5.37159  45.84817 21.40664 1.000 71.23650  ? 161 ASP A CB  1 
ATOM   1410 C CG  . ASP A 1 166 ? -5.04158  46.69996 22.62603 1.000 87.87059  ? 161 ASP A CG  1 
ATOM   1411 O OD1 . ASP A 1 166 ? -5.63016  47.79552 22.78182 1.000 89.50067  ? 161 ASP A OD1 1 
ATOM   1412 O OD2 . ASP A 1 166 ? -4.19806  46.26235 23.43611 1.000 90.17295  ? 161 ASP A OD2 1 
ATOM   1413 N N   . CYS A 1 167 ? -7.10592  42.71791 20.97579 1.000 63.37825  ? 162 CYS A N   1 
ATOM   1414 C CA  . CYS A 1 167 ? -7.26872  41.56561 20.09569 1.000 65.17477  ? 162 CYS A CA  1 
ATOM   1415 C C   . CYS A 1 167 ? -5.94254  41.00449 19.60731 1.000 47.52975  ? 162 CYS A C   1 
ATOM   1416 O O   . CYS A 1 167 ? -5.91065  40.25585 18.61730 1.000 52.76739  ? 162 CYS A O   1 
ATOM   1417 C CB  . CYS A 1 167 ? -8.14044  41.91189 18.88983 1.000 83.68959  ? 162 CYS A CB  1 
ATOM   1418 S SG  . CYS A 1 167 ? -9.88381  41.69621 19.18513 1.000 107.63907 ? 162 CYS A SG  1 
ATOM   1419 N N   . GLU A 1 168 ? -4.84749  41.36709 20.26574 1.000 47.93058  ? 163 GLU A N   1 
ATOM   1420 C CA  . GLU A 1 168 ? -3.54067  40.84910 19.89852 1.000 48.97135  ? 163 GLU A CA  1 
ATOM   1421 C C   . GLU A 1 168 ? -3.33455  39.48620 20.52985 1.000 48.51545  ? 163 GLU A C   1 
ATOM   1422 O O   . GLU A 1 168 ? -3.68723  39.27106 21.68880 1.000 50.35895  ? 163 GLU A O   1 
ATOM   1423 C CB  . GLU A 1 168 ? -2.43298  41.80730 20.33458 1.000 53.18759  ? 163 GLU A CB  1 
ATOM   1424 C CG  . GLU A 1 168 ? -2.28848  43.01687 19.42780 1.000 67.06910  ? 163 GLU A CG  1 
ATOM   1425 C CD  . GLU A 1 168 ? -1.68335  44.21402 20.13437 1.000 64.56023  ? 163 GLU A CD  1 
ATOM   1426 O OE1 . GLU A 1 168 ? -1.40032  44.11768 21.34841 1.000 74.41671  ? 163 GLU A OE1 1 
ATOM   1427 O OE2 . GLU A 1 168 ? -1.46648  45.24618 19.46682 1.000 78.78548  ? 163 GLU A OE2 1 
ATOM   1428 N N   . LEU A 1 169 ? -2.75868  38.56201 19.76868 1.000 39.64332  ? 164 LEU A N   1 
ATOM   1429 C CA  . LEU A 1 169 ? -2.73774  37.16273 20.18106 1.000 36.85419  ? 164 LEU A CA  1 
ATOM   1430 C C   . LEU A 1 169 ? -1.31198  36.64401 20.27013 1.000 38.79049  ? 164 LEU A C   1 
ATOM   1431 O O   . LEU A 1 169 ? -0.43392  37.03324 19.48375 1.000 39.52869  ? 164 LEU A O   1 
ATOM   1432 C CB  . LEU A 1 169 ? -3.54815  36.29577 19.22402 1.000 36.85771  ? 164 LEU A CB  1 
ATOM   1433 C CG  . LEU A 1 169 ? -3.52646  34.80285 19.52276 1.000 38.92421  ? 164 LEU A CG  1 
ATOM   1434 C CD1 . LEU A 1 169 ? -4.79361  34.22024 18.91623 1.000 39.39100  ? 164 LEU A CD1 1 
ATOM   1435 C CD2 . LEU A 1 169 ? -2.23563  34.19255 18.86275 1.000 39.17036  ? 164 LEU A CD2 1 
ATOM   1436 N N   . LYS A 1 170 ? -1.10070  35.76262 21.24513 1.000 35.14473  ? 165 LYS A N   1 
ATOM   1437 C CA  . LYS A 1 170 ? 0.18179   35.12178 21.48276 1.000 42.96624  ? 165 LYS A CA  1 
ATOM   1438 C C   . LYS A 1 170 ? -0.04063  33.63303 21.63399 1.000 41.42150  ? 165 LYS A C   1 
ATOM   1439 O O   . LYS A 1 170 ? -0.92949  33.21096 22.38511 1.000 33.80460  ? 165 LYS A O   1 
ATOM   1440 C CB  . LYS A 1 170 ? 0.87098   35.65853 22.73997 1.000 41.71929  ? 165 LYS A CB  1 
ATOM   1441 C CG  . LYS A 1 170 ? 1.66754   36.92145 22.58528 1.000 54.12707  ? 165 LYS A CG  1 
ATOM   1442 C CD  . LYS A 1 170 ? 2.28250   37.25997 23.95277 1.000 52.07020  ? 165 LYS A CD  1 
ATOM   1443 C CE  . LYS A 1 170 ? 3.19719   38.47853 23.96403 1.000 65.94067  ? 165 LYS A CE  1 
ATOM   1444 N NZ  . LYS A 1 170 ? 3.34783   39.17779 22.66044 1.000 70.15250  ? 165 LYS A NZ  1 
ATOM   1445 N N   . ILE A 1 171 ? 0.80726   32.84066 20.97552 1.000 35.43595  ? 166 ILE A N   1 
ATOM   1446 C CA  . ILE A 1 171 ? 0.81258   31.40157 21.20536 1.000 32.25358  ? 166 ILE A CA  1 
ATOM   1447 C C   . ILE A 1 171 ? 1.66122   31.08524 22.43214 1.000 35.59178  ? 166 ILE A C   1 
ATOM   1448 O O   . ILE A 1 171 ? 2.83514   31.48163 22.50547 1.000 38.88281  ? 166 ILE A O   1 
ATOM   1449 C CB  . ILE A 1 171 ? 1.36704   30.65641 19.98513 1.000 35.38495  ? 166 ILE A CB  1 
ATOM   1450 C CG1 . ILE A 1 171 ? 0.53622   30.94087 18.72156 1.000 31.59791  ? 166 ILE A CG1 1 
ATOM   1451 C CG2 . ILE A 1 171 ? 1.39571   29.16315 20.31852 1.000 32.64814  ? 166 ILE A CG2 1 
ATOM   1452 C CD1 . ILE A 1 171 ? 1.23397   30.42933 17.44242 1.000 34.25367  ? 166 ILE A CD1 1 
ATOM   1453 N N   . LEU A 1 172 ? 1.11109   30.27945 23.34096 1.000 31.20756  ? 167 LEU A N   1 
ATOM   1454 C CA  . LEU A 1 172 ? 1.68006   29.93949 24.64880 1.000 52.52890  ? 167 LEU A CA  1 
ATOM   1455 C C   . LEU A 1 172 ? 2.00403   28.45057 24.74001 1.000 47.68196  ? 167 LEU A C   1 
ATOM   1456 O O   . LEU A 1 172 ? 1.52425   27.64226 23.93056 1.000 41.01796  ? 167 LEU A O   1 
ATOM   1457 C CB  . LEU A 1 172 ? 0.67690   30.27092 25.76590 1.000 46.80348  ? 167 LEU A CB  1 
ATOM   1458 C CG  . LEU A 1 172 ? 0.58241   31.66504 26.37299 1.000 67.39824  ? 167 LEU A CG  1 
ATOM   1459 C CD1 . LEU A 1 172 ? 0.63640   32.74030 25.30345 1.000 52.22691  ? 167 LEU A CD1 1 
ATOM   1460 C CD2 . LEU A 1 172 ? -0.75729  31.75510 27.08713 1.000 64.17401  ? 167 LEU A CD2 1 
ATOM   1461 N N   A ASP A 1 173 ? 2.75287   28.10737 25.79775 0.590 50.87708  ? 168 ASP A N   1 
ATOM   1462 N N   B ASP A 1 173 ? 2.78345   28.08191 25.76648 0.410 50.89858  ? 168 ASP A N   1 
ATOM   1463 C CA  A ASP A 1 173 ? 3.02228   26.73760 26.22841 0.590 50.91212  ? 168 ASP A CA  1 
ATOM   1464 C CA  B ASP A 1 173 ? 3.04570   26.68466 26.11759 0.410 51.05736  ? 168 ASP A CA  1 
ATOM   1465 C C   A ASP A 1 173 ? 3.96430   25.99673 25.29849 0.590 52.32150  ? 168 ASP A C   1 
ATOM   1466 C C   B ASP A 1 173 ? 3.98955   25.97069 25.15950 0.410 52.13923  ? 168 ASP A C   1 
ATOM   1467 O O   A ASP A 1 173 ? 5.18268   26.00900 25.50515 0.590 61.84787  ? 168 ASP A O   1 
ATOM   1468 O O   B ASP A 1 173 ? 3.54717   25.45710 24.13581 0.410 52.98087  ? 168 ASP A O   1 
ATOM   1469 C CB  A ASP A 1 173 ? 1.72636   25.94439 26.36631 0.590 53.52903  ? 168 ASP A CB  1 
ATOM   1470 C CB  B ASP A 1 173 ? 1.73739   25.89294 26.18702 0.410 53.35555  ? 168 ASP A CB  1 
ATOM   1471 C CG  A ASP A 1 173 ? 1.02797   26.19252 27.69071 0.590 62.46878  ? 168 ASP A CG  1 
ATOM   1472 C CG  B ASP A 1 173 ? 0.97107   26.13400 27.46853 0.410 61.78066  ? 168 ASP A CG  1 
ATOM   1473 O OD1 A ASP A 1 173 ? 1.38339   27.17614 28.39587 0.590 61.99293  ? 168 ASP A OD1 1 
ATOM   1474 O OD1 B ASP A 1 173 ? 1.20151   27.17647 28.12821 0.410 62.96577  ? 168 ASP A OD1 1 
ATOM   1475 O OD2 A ASP A 1 173 ? 0.11539   25.39886 28.01913 0.590 67.16949  ? 168 ASP A OD2 1 
ATOM   1476 O OD2 B ASP A 1 173 ? 0.13047   25.27158 27.81021 0.410 65.87702  ? 168 ASP A OD2 1 
ATOM   1477 N N   A PHE A 1 174 ? 3.39434   25.34310 24.28764 0.590 53.48830  ? 169 PHE A N   1 
ATOM   1478 N N   B PHE A 1 174 ? 5.27279   25.88681 25.49449 0.410 61.33403  ? 169 PHE A N   1 
ATOM   1479 C CA  A PHE A 1 174 ? 4.10864   24.42611 23.40799 0.590 50.93392  ? 169 PHE A CA  1 
ATOM   1480 C CA  B PHE A 1 174 ? 6.21999   25.04714 24.77740 0.410 50.88351  ? 169 PHE A CA  1 
ATOM   1481 C C   A PHE A 1 174 ? 4.06538   23.04609 24.03695 0.590 46.29057  ? 169 PHE A C   1 
ATOM   1482 C C   B PHE A 1 174 ? 6.93457   24.17206 25.78799 0.410 51.42983  ? 169 PHE A C   1 
ATOM   1483 O O   A PHE A 1 174 ? 4.29786   22.89412 25.24182 0.590 43.76115  ? 169 PHE A O   1 
ATOM   1484 O O   B PHE A 1 174 ? 6.65768   24.21123 26.99537 0.410 66.08427  ? 169 PHE A O   1 
ATOM   1485 C CB  A PHE A 1 174 ? 5.54219   24.89695 23.17614 0.590 45.81305  ? 169 PHE A CB  1 
ATOM   1486 C CB  B PHE A 1 174 ? 7.20335   25.88041 23.94531 0.410 51.44390  ? 169 PHE A CB  1 
ATOM   1487 C CG  A PHE A 1 174 ? 5.63802   26.07705 22.26053 0.590 45.00317  ? 169 PHE A CG  1 
ATOM   1488 C CG  B PHE A 1 174 ? 6.58905   26.47440 22.73454 0.410 45.23776  ? 169 PHE A CG  1 
ATOM   1489 C CD1 A PHE A 1 174 ? 5.79362   25.91121 20.89500 0.590 46.02826  ? 169 PHE A CD1 1 
ATOM   1490 C CD1 B PHE A 1 174 ? 6.42498   25.71217 21.58946 0.410 47.74450  ? 169 PHE A CD1 1 
ATOM   1491 C CD2 A PHE A 1 174 ? 5.49524   27.35838 22.76777 0.590 47.36782  ? 169 PHE A CD2 1 
ATOM   1492 C CD2 B PHE A 1 174 ? 6.13861   27.77570 22.74338 0.410 50.14179  ? 169 PHE A CD2 1 
ATOM   1493 C CE1 A PHE A 1 174 ? 5.86391   27.01382 20.05532 0.590 41.31226  ? 169 PHE A CE1 1 
ATOM   1494 C CE1 B PHE A 1 174 ? 5.84777   26.25414 20.46087 0.410 44.46283  ? 169 PHE A CE1 1 
ATOM   1495 C CE2 A PHE A 1 174 ? 5.53928   28.46052 21.94876 0.590 42.73998  ? 169 PHE A CE2 1 
ATOM   1496 C CE2 B PHE A 1 174 ? 5.55131   28.32774 21.62594 0.410 43.35472  ? 169 PHE A CE2 1 
ATOM   1497 C CZ  A PHE A 1 174 ? 5.72346   28.29008 20.58189 0.590 43.96691  ? 169 PHE A CZ  1 
ATOM   1498 C CZ  B PHE A 1 174 ? 5.40968   27.56514 20.47594 0.410 46.26730  ? 169 PHE A CZ  1 
ATOM   1499 N N   A GLY A 1 175 ? 3.71261   22.04659 23.25011 0.590 45.09632  ? 170 GLY A N   1 
ATOM   1500 N N   B GLY A 1 175 ? 7.89188   23.40263 25.31165 0.410 60.82114  ? 170 GLY A N   1 
ATOM   1501 C CA  A GLY A 1 175 ? 3.72911   20.70247 23.77761 0.590 61.82972  ? 170 GLY A CA  1 
ATOM   1502 C CA  B GLY A 1 175 ? 8.37881   22.34926 26.16966 0.410 59.88621  ? 170 GLY A CA  1 
ATOM   1503 C C   A GLY A 1 175 ? 5.13792   20.19984 24.00716 0.590 69.22919  ? 170 GLY A C   1 
ATOM   1504 C C   B GLY A 1 175 ? 7.27338   21.45135 26.66638 0.410 63.93189  ? 170 GLY A C   1 
ATOM   1505 O O   A GLY A 1 175 ? 5.86809   19.85179 23.06789 0.590 68.36221  ? 170 GLY A O   1 
ATOM   1506 O O   B GLY A 1 175 ? 7.33061   20.98290 27.80450 0.410 61.42417  ? 170 GLY A O   1 
ATOM   1507 N N   A LEU A 1 176 ? 5.51732   20.15174 25.28026 0.590 65.97237  ? 171 LEU A N   1 
ATOM   1508 N N   B LEU A 1 176 ? 6.21259   21.31251 25.86716 0.410 71.16963  ? 171 LEU A N   1 
ATOM   1509 C CA  A LEU A 1 176 ? 6.89160   19.83648 25.63908 0.590 66.62623  ? 171 LEU A CA  1 
ATOM   1510 C CA  B LEU A 1 176 ? 5.05079   20.53007 26.25067 0.410 69.89366  ? 171 LEU A CA  1 
ATOM   1511 C C   A LEU A 1 176 ? 7.13074   18.33350 25.61448 0.590 77.04644  ? 171 LEU A C   1 
ATOM   1512 C C   B LEU A 1 176 ? 5.49200   19.16370 26.73666 0.410 71.43510  ? 171 LEU A C   1 
ATOM   1513 O O   A LEU A 1 176 ? 8.14063   17.86502 25.07602 0.590 76.75283  ? 171 LEU A O   1 
ATOM   1514 O O   B LEU A 1 176 ? 5.08806   18.71154 27.80924 0.410 73.72259  ? 171 LEU A O   1 
ATOM   1515 C CB  A LEU A 1 176 ? 7.20143   20.39806 27.02208 0.590 64.56735  ? 171 LEU A CB  1 
ATOM   1516 C CB  B LEU A 1 176 ? 4.10263   20.40578 25.05404 0.410 67.96425  ? 171 LEU A CB  1 
ATOM   1517 C CG  A LEU A 1 176 ? 7.94768   21.72243 27.00034 0.590 64.45393  ? 171 LEU A CG  1 
ATOM   1518 C CG  B LEU A 1 176 ? 4.51184   20.81896 23.62921 0.410 66.39439  ? 171 LEU A CG  1 
ATOM   1519 C CD1 A LEU A 1 176 ? 8.25209   22.11236 25.56031 0.590 56.75401  ? 171 LEU A CD1 1 
ATOM   1520 C CD1 B LEU A 1 176 ? 4.53045   22.33266 23.44670 0.410 54.41820  ? 171 LEU A CD1 1 
ATOM   1521 C CD2 A LEU A 1 176 ? 7.11466   22.76553 27.68445 0.590 63.24845  ? 171 LEU A CD2 1 
ATOM   1522 C CD2 B LEU A 1 176 ? 5.85608   20.16464 23.21776 0.410 67.75616  ? 171 LEU A CD2 1 
ATOM   1523 N N   A ALA A 1 177 ? 6.19786   17.57191 26.18841 0.590 81.18185  ? 172 ALA A N   1 
ATOM   1524 N N   B ALA A 1 177 ? 6.34140   18.49856 25.95399 0.410 77.74006  ? 172 ALA A N   1 
ATOM   1525 C CA  A ALA A 1 177 ? 6.26233   16.12026 26.29817 0.590 81.81344  ? 172 ALA A CA  1 
ATOM   1526 C CA  B ALA A 1 177 ? 7.03374   17.28940 26.38161 0.410 79.27943  ? 172 ALA A CA  1 
ATOM   1527 C C   A ALA A 1 177 ? 5.38763   15.71040 27.47785 0.590 84.74520  ? 172 ALA A C   1 
ATOM   1528 C C   B ALA A 1 177 ? 6.10409   16.08158 26.47933 0.410 81.71535  ? 172 ALA A C   1 
ATOM   1529 O O   A ALA A 1 177 ? 5.79682   14.88622 28.30112 0.590 83.06447  ? 172 ALA A O   1 
ATOM   1530 O O   B ALA A 1 177 ? 6.48065   14.98209 26.05664 0.410 81.97396  ? 172 ALA A O   1 
ATOM   1531 C CB  A ALA A 1 177 ? 7.70473   15.62022 26.47663 0.590 80.60534  ? 172 ALA A CB  1 
ATOM   1532 C CB  B ALA A 1 177 ? 7.73957   17.52460 27.72139 0.410 74.92180  ? 172 ALA A CB  1 
ATOM   1533 N N   A ARG A 1 178 ? 4.18514   16.29004 27.57102 0.590 83.16586  ? 173 ARG A N   1 
ATOM   1534 N N   B ARG A 1 178 ? 4.89622   16.24901 27.01961 0.410 84.19100  ? 173 ARG A N   1 
ATOM   1535 C CA  A ARG A 1 178 ? 3.27602   16.04907 28.68520 0.590 83.31473  ? 173 ARG A CA  1 
ATOM   1536 C CA  B ARG A 1 178 ? 4.10629   15.06601 27.34365 0.410 81.72036  ? 173 ARG A CA  1 
ATOM   1537 C C   A ARG A 1 178 ? 2.23898   14.99945 28.28805 0.590 83.11634  ? 173 ARG A C   1 
ATOM   1538 C C   B ARG A 1 178 ? 2.65774   15.44362 27.61318 0.410 82.66204  ? 173 ARG A C   1 
ATOM   1539 O O   A ARG A 1 178 ? 2.58783   13.84661 27.99842 0.590 78.98823  ? 173 ARG A O   1 
ATOM   1540 O O   B ARG A 1 178 ? 2.29803   16.62040 27.70852 0.410 83.99742  ? 173 ARG A O   1 
ATOM   1541 C CB  A ARG A 1 178 ? 2.61260   17.36956 29.11834 0.590 74.90186  ? 173 ARG A CB  1 
ATOM   1542 C CB  B ARG A 1 178 ? 4.70688   14.32968 28.54710 0.410 85.23215  ? 173 ARG A CB  1 
ATOM   1543 C CG  A ARG A 1 178 ? 3.44491   18.22782 30.08256 0.590 79.39810  ? 173 ARG A CG  1 
ATOM   1544 C CG  B ARG A 1 178 ? 5.21767   12.94139 28.21134 0.410 87.89098  ? 173 ARG A CG  1 
ATOM   1545 C CD  A ARG A 1 178 ? 4.67611   18.85112 29.40433 0.590 74.39880  ? 173 ARG A CD  1 
ATOM   1546 C CD  B ARG A 1 178 ? 6.48597   12.61342 28.98233 0.410 82.39753  ? 173 ARG A CD  1 
ATOM   1547 N NE  A ARG A 1 178 ? 4.79435   20.27229 29.72923 0.590 81.61168  ? 173 ARG A NE  1 
ATOM   1548 N NE  B ARG A 1 178 ? 7.28844   11.63322 28.25825 0.410 77.28041  ? 173 ARG A NE  1 
ATOM   1549 C CZ  A ARG A 1 178 ? 4.40274   21.25991 28.93050 0.590 75.49100  ? 173 ARG A CZ  1 
ATOM   1550 C CZ  B ARG A 1 178 ? 8.14586   11.93669 27.29158 0.410 74.49135  ? 173 ARG A CZ  1 
ATOM   1551 N NH1 A ARG A 1 178 ? 3.85038   21.01811 27.75107 0.590 69.90832  ? 173 ARG A NH1 1 
ATOM   1552 N NH1 B ARG A 1 178 ? 8.34906   13.18933 26.91446 0.410 77.91508  ? 173 ARG A NH1 1 
ATOM   1553 N NH2 A ARG A 1 178 ? 4.54627   22.52036 29.33431 0.590 67.99008  ? 173 ARG A NH2 1 
ATOM   1554 N NH2 B ARG A 1 178 ? 8.80998   10.95872 26.68179 0.410 70.16517  ? 173 ARG A NH2 1 
ATOM   1555 N N   A HIS A 1 179 ? 0.96441   15.40193 28.25850 0.590 81.30605  ? 174 HIS A N   1 
ATOM   1556 N N   B HIS A 1 179 ? 1.83385   14.39881 27.72375 0.410 82.31894  ? 174 HIS A N   1 
ATOM   1557 C CA  A HIS A 1 179 ? -0.14264  14.58365 27.76356 0.590 76.53148  ? 174 HIS A CA  1 
ATOM   1558 C CA  B HIS A 1 179 ? 0.41626   14.43765 28.06809 0.410 77.96926  ? 174 HIS A CA  1 
ATOM   1559 C C   A HIS A 1 179 ? -0.12204  13.13883 28.24927 0.590 67.47309  ? 174 HIS A C   1 
ATOM   1560 C C   B HIS A 1 179 ? 0.00640   13.01742 28.44056 0.410 68.08886  ? 174 HIS A C   1 
ATOM   1561 O O   A HIS A 1 179 ? 0.39028   12.25156 27.55927 0.590 66.68621  ? 174 HIS A O   1 
ATOM   1562 O O   B HIS A 1 179 ? 0.32498   12.07018 27.71513 0.410 66.66520  ? 174 HIS A O   1 
ATOM   1563 C CB  A HIS A 1 179 ? -0.17297  14.59074 26.23068 0.590 79.94575  ? 174 HIS A CB  1 
ATOM   1564 C CB  B HIS A 1 179 ? -0.43359  14.96394 26.90585 0.410 78.94829  ? 174 HIS A CB  1 
ATOM   1565 C CG  A HIS A 1 179 ? -0.25179  15.95926 25.63077 0.590 79.83064  ? 174 HIS A CG  1 
ATOM   1566 C CG  B HIS A 1 179 ? -1.05140  16.30772 27.15453 0.410 78.56547  ? 174 HIS A CG  1 
ATOM   1567 N ND1 A HIS A 1 179 ? -0.73749  17.04835 26.32304 0.590 79.27097  ? 174 HIS A ND1 1 
ATOM   1568 N ND1 B HIS A 1 179 ? -1.91871  16.55272 28.19818 0.410 77.75852  ? 174 HIS A ND1 1 
ATOM   1569 C CD2 A HIS A 1 179 ? 0.11438   16.42013 24.41136 0.590 80.02927  ? 174 HIS A CD2 1 
ATOM   1570 C CD2 B HIS A 1 179 ? -0.92878  17.47960 26.48657 0.410 77.19121  ? 174 HIS A CD2 1 
ATOM   1571 C CE1 A HIS A 1 179 ? -0.67580  18.11970 25.55330 0.590 82.71891  ? 174 HIS A CE1 1 
ATOM   1572 C CE1 B HIS A 1 179 ? -2.29869  17.81833 28.16468 0.410 70.26713  ? 174 HIS A CE1 1 
ATOM   1573 N NE2 A HIS A 1 179 ? -0.16123  17.76651 24.38790 0.590 81.02317  ? 174 HIS A NE2 1 
ATOM   1574 N NE2 B HIS A 1 179 ? -1.71125  18.40289 27.13641 0.410 66.46702  ? 174 HIS A NE2 1 
ATOM   1575 N N   A THR A 1 180 ? -0.69348  12.88685 29.42255 0.590 68.64537  ? 175 THR A N   1 
ATOM   1576 N N   B THR A 1 180 ? -0.67294  12.84247 29.56847 0.410 68.63428  ? 175 THR A N   1 
ATOM   1577 C CA  A THR A 1 180 ? -0.90511  11.51527 29.86309 0.590 69.81261  ? 175 THR A CA  1 
ATOM   1578 C CA  B THR A 1 180 ? -0.98439  11.49655 30.02864 0.410 69.78193  ? 175 THR A CA  1 
ATOM   1579 C C   A THR A 1 180 ? -2.12160  10.90866 29.16688 0.590 67.60884  ? 175 THR A C   1 
ATOM   1580 C C   B THR A 1 180 ? -2.16152  10.90420 29.25366 0.410 67.57848  ? 175 THR A C   1 
ATOM   1581 O O   A THR A 1 180 ? -3.04213  11.61257 28.73619 0.590 58.45888  ? 175 THR A O   1 
ATOM   1582 O O   B THR A 1 180 ? -3.08200  11.61213 28.83185 0.410 58.59890  ? 175 THR A O   1 
ATOM   1583 C CB  A THR A 1 180 ? -1.10271  11.44990 31.37604 0.590 70.81233  ? 175 THR A CB  1 
ATOM   1584 C CB  B THR A 1 180 ? -1.29301  11.49164 31.52764 0.410 70.62362  ? 175 THR A CB  1 
ATOM   1585 O OG1 A THR A 1 180 ? -2.45743  11.79990 31.69532 0.590 57.05301  ? 175 THR A OG1 1 
ATOM   1586 O OG1 B THR A 1 180 ? -0.63047  12.59542 32.15948 0.410 76.25789  ? 175 THR A OG1 1 
ATOM   1587 C CG2 A THR A 1 180 ? -0.13684  12.41568 32.07913 0.590 74.32348  ? 175 THR A CG2 1 
ATOM   1588 C CG2 B THR A 1 180 ? -0.79319  10.20301 32.16381 0.410 68.09088  ? 175 THR A CG2 1 
ATOM   1589 N N   . ASP A 1 181 ? -2.11822  9.58011  29.06709 1.000 66.27383  ? 176 ASP A N   1 
ATOM   1590 C CA  . ASP A 1 181 ? -3.22951  8.88591  28.42369 1.000 69.22866  ? 176 ASP A CA  1 
ATOM   1591 C C   . ASP A 1 181 ? -4.54604  9.20224  29.11272 1.000 62.46482  ? 176 ASP A C   1 
ATOM   1592 O O   . ASP A 1 181 ? -5.58747  9.32594  28.45465 1.000 55.61027  ? 176 ASP A O   1 
ATOM   1593 C CB  . ASP A 1 181 ? -2.96688  7.37628  28.41449 1.000 67.59440  ? 176 ASP A CB  1 
ATOM   1594 C CG  . ASP A 1 181 ? -1.81113  6.99477  27.49380 1.000 87.14571  ? 176 ASP A CG  1 
ATOM   1595 O OD1 . ASP A 1 181 ? -1.39957  7.85988  26.68132 1.000 80.87335  ? 176 ASP A OD1 1 
ATOM   1596 O OD2 . ASP A 1 181 ? -1.30789  5.85000  27.59225 1.000 82.00445  ? 176 ASP A OD2 1 
ATOM   1597 N N   . ASP A 1 182 ? -4.51865  9.33276  30.44073 1.000 56.69051  ? 177 ASP A N   1 
ATOM   1598 C CA  . ASP A 1 182 ? -5.74685  9.62121  31.17066 1.000 56.32668  ? 177 ASP A CA  1 
ATOM   1599 C C   . ASP A 1 182 ? -6.24004  11.03416 30.87593 1.000 60.08563  ? 177 ASP A C   1 
ATOM   1600 O O   . ASP A 1 182 ? -7.45525  11.27400 30.79159 1.000 54.91292  ? 177 ASP A O   1 
ATOM   1601 C CB  . ASP A 1 182 ? -5.53915  9.41192  32.67537 1.000 63.66198  ? 177 ASP A CB  1 
ATOM   1602 C CG  . ASP A 1 182 ? -6.79766  9.73276  33.48851 1.000 84.54500  ? 177 ASP A CG  1 
ATOM   1603 O OD1 . ASP A 1 182 ? -6.86532  10.84377 34.07014 1.000 82.10276  ? 177 ASP A OD1 1 
ATOM   1604 O OD2 . ASP A 1 182 ? -7.73576  8.89946  33.50871 1.000 83.67432  ? 177 ASP A OD2 1 
ATOM   1605 N N   . GLU A 1 183 ? -5.31611  11.98286 30.70879 1.000 54.57317  ? 178 GLU A N   1 
ATOM   1606 C CA  . GLU A 1 183 ? -5.72276  13.34485 30.36884 1.000 62.76150  ? 178 GLU A CA  1 
ATOM   1607 C C   . GLU A 1 183 ? -6.25347  13.47925 28.94358 1.000 59.07885  ? 178 GLU A C   1 
ATOM   1608 O O   . GLU A 1 183 ? -6.79137  14.53655 28.59710 1.000 60.55172  ? 178 GLU A O   1 
ATOM   1609 C CB  . GLU A 1 183 ? -4.55979  14.30932 30.60815 1.000 68.18145  ? 178 GLU A CB  1 
ATOM   1610 C CG  . GLU A 1 183 ? -4.39331  14.69966 32.08114 1.000 67.91931  ? 178 GLU A CG  1 
ATOM   1611 C CD  . GLU A 1 183 ? -2.98721  15.17670 32.41196 1.000 90.34787  ? 178 GLU A CD  1 
ATOM   1612 O OE1 . GLU A 1 183 ? -2.09982  15.12912 31.51899 1.000 87.97219  ? 178 GLU A OE1 1 
ATOM   1613 O OE2 . GLU A 1 183 ? -2.78028  15.61572 33.56580 1.000 75.75391  ? 178 GLU A OE2 1 
ATOM   1614 N N   . MET A 1 184 ? -6.15431  12.43540 28.12827 1.000 49.51153  ? 179 MET A N   1 
ATOM   1615 C CA  . MET A 1 184 ? -6.65392  12.46225 26.76583 1.000 47.68956  ? 179 MET A CA  1 
ATOM   1616 C C   . MET A 1 184 ? -7.91507  11.62169 26.57178 1.000 43.24472  ? 179 MET A C   1 
ATOM   1617 O O   . MET A 1 184 ? -8.41855  11.53412 25.43991 1.000 37.95601  ? 179 MET A O   1 
ATOM   1618 C CB  . MET A 1 184 ? -5.55935  11.95814 25.81372 1.000 52.69862  ? 179 MET A CB  1 
ATOM   1619 C CG  . MET A 1 184 ? -4.35354  12.87955 25.74506 1.000 64.63076  ? 179 MET A CG  1 
ATOM   1620 S SD  . MET A 1 184 ? -4.73128  14.40840 24.86502 1.000 80.66035  ? 179 MET A SD  1 
ATOM   1621 C CE  . MET A 1 184 ? -3.21719  14.67233 23.95646 1.000 78.31353  ? 179 MET A CE  1 
ATOM   1622 N N   A THR A 1 185 ? -8.42599  10.97207 27.61878 0.380 40.77491  ? 180 THR A N   1 
ATOM   1623 N N   B THR A 1 185 ? -8.43661  10.99229 27.62222 0.620 40.63910  ? 180 THR A N   1 
ATOM   1624 C CA  A THR A 1 185 ? -9.55111  10.05557 27.45912 0.380 37.13942  ? 180 THR A CA  1 
ATOM   1625 C CA  B THR A 1 185 ? -9.55227  10.06896 27.46322 0.620 36.94531  ? 180 THR A CA  1 
ATOM   1626 C C   A THR A 1 185 ? -10.86784 10.76337 27.75069 0.380 42.56929  ? 180 THR A C   1 
ATOM   1627 C C   B THR A 1 185 ? -10.85977 10.80286 27.71965 0.620 42.59485  ? 180 THR A C   1 
ATOM   1628 O O   A THR A 1 185 ? -10.95682 11.58573 28.66817 0.380 38.41180  ? 180 THR A O   1 
ATOM   1629 O O   B THR A 1 185 ? -10.93486 11.67571 28.58949 0.620 38.21152  ? 180 THR A O   1 
ATOM   1630 C CB  A THR A 1 185 ? -9.39642  8.82927  28.36626 0.380 48.17130  ? 180 THR A CB  1 
ATOM   1631 C CB  B THR A 1 185 ? -9.44093  8.87729  28.41340 0.620 48.26470  ? 180 THR A CB  1 
ATOM   1632 O OG1 A THR A 1 185 ? -10.59996 8.04335  28.35281 0.380 44.14674  ? 180 THR A OG1 1 
ATOM   1633 O OG1 B THR A 1 185 ? -9.52566  9.34387  29.75918 0.620 61.32964  ? 180 THR A OG1 1 
ATOM   1634 C CG2 A THR A 1 185 ? -9.10418  9.26075  29.78158 0.380 59.04032  ? 180 THR A CG2 1 
ATOM   1635 C CG2 B THR A 1 185 ? -8.08868  8.19483  28.23204 0.620 29.00568  ? 180 THR A CG2 1 
ATOM   1636 N N   . GLY A 1 186 ? -11.88208 10.45217 26.94586 1.000 41.85768  ? 181 GLY A N   1 
ATOM   1637 C CA  . GLY A 1 186 ? -13.22604 10.96541 27.16764 1.000 41.17687  ? 181 GLY A CA  1 
ATOM   1638 C C   . GLY A 1 186 ? -13.54377 12.30363 26.52251 1.000 44.30300  ? 181 GLY A C   1 
ATOM   1639 O O   . GLY A 1 186 ? -12.97105 12.72533 25.51408 1.000 36.62895  ? 181 GLY A O   1 
ATOM   1640 N N   . TYR A 1 187 ? -14.53128 12.96993 27.11873 1.000 38.18823  ? 182 TYR A N   1 
ATOM   1641 C CA  . TYR A 1 187 ? -15.06649 14.21529 26.56560 1.000 40.06123  ? 182 TYR A CA  1 
ATOM   1642 C C   . TYR A 1 187 ? -14.22946 15.37720 27.09601 1.000 48.41410  ? 182 TYR A C   1 
ATOM   1643 O O   . TYR A 1 187 ? -14.60629 16.05398 28.04659 1.000 40.24641  ? 182 TYR A O   1 
ATOM   1644 C CB  . TYR A 1 187 ? -16.54546 14.34674 26.93156 1.000 38.73447  ? 182 TYR A CB  1 
ATOM   1645 C CG  . TYR A 1 187 ? -17.30248 15.48389 26.29736 1.000 40.43612  ? 182 TYR A CG  1 
ATOM   1646 C CD1 . TYR A 1 187 ? -17.67340 15.44031 24.96039 1.000 38.29080  ? 182 TYR A CD1 1 
ATOM   1647 C CD2 . TYR A 1 187 ? -17.70247 16.57467 27.05946 1.000 37.01825  ? 182 TYR A CD2 1 
ATOM   1648 C CE1 . TYR A 1 187 ? -18.38765 16.48070 24.37170 1.000 42.91908  ? 182 TYR A CE1 1 
ATOM   1649 C CE2 . TYR A 1 187 ? -18.40812 17.62505 26.49514 1.000 36.39612  ? 182 TYR A CE2 1 
ATOM   1650 C CZ  . TYR A 1 187 ? -18.75668 17.56456 25.15793 1.000 43.07893  ? 182 TYR A CZ  1 
ATOM   1651 O OH  . TYR A 1 187 ? -19.45066 18.60679 24.62907 1.000 46.51421  ? 182 TYR A OH  1 
ATOM   1652 N N   . VAL A 1 188 ? -13.05985 15.60801 26.47980 1.000 36.86354  ? 183 VAL A N   1 
ATOM   1653 C CA  . VAL A 1 188 ? -12.09524 16.57102 27.02729 1.000 35.98722  ? 183 VAL A CA  1 
ATOM   1654 C C   . VAL A 1 188 ? -11.49250 17.42787 25.90469 1.000 37.43279  ? 183 VAL A C   1 
ATOM   1655 O O   . VAL A 1 188 ? -11.04610 16.91474 24.86513 1.000 33.67242  ? 183 VAL A O   1 
ATOM   1656 C CB  . VAL A 1 188 ? -10.97974 15.87250 27.84927 1.000 37.15295  ? 183 VAL A CB  1 
ATOM   1657 C CG1 . VAL A 1 188 ? -11.52424 15.44446 29.24992 1.000 43.59169  ? 183 VAL A CG1 1 
ATOM   1658 C CG2 . VAL A 1 188 ? -10.35274 14.70210 27.11294 1.000 42.16406  ? 183 VAL A CG2 1 
ATOM   1659 N N   . ALA A 1 189 ? -11.45146 18.74357 26.12692 1.000 39.05869  ? 184 ALA A N   1 
ATOM   1660 C CA  . ALA A 1 189 ? -10.87082 19.63004 25.12396 1.000 39.59265  ? 184 ALA A CA  1 
ATOM   1661 C C   . ALA A 1 189 ? -9.39218  19.34506 24.87964 1.000 39.25848  ? 184 ALA A C   1 
ATOM   1662 O O   . ALA A 1 189 ? -8.82293  19.85610 23.89877 1.000 41.09357  ? 184 ALA A O   1 
ATOM   1663 C CB  . ALA A 1 189 ? -11.09286 21.08611 25.54372 1.000 45.11296  ? 184 ALA A CB  1 
ATOM   1664 N N   . THR A 1 190 ? -8.75694  18.51392 25.71466 1.000 40.28111  ? 185 THR A N   1 
ATOM   1665 C CA  . THR A 1 190 ? -7.34778  18.20782 25.50492 1.000 39.63571  ? 185 THR A CA  1 
ATOM   1666 C C   . THR A 1 190 ? -7.13643  17.38829 24.23015 1.000 44.35818  ? 185 THR A C   1 
ATOM   1667 O O   . THR A 1 190 ? -6.02394  17.37124 23.69644 1.000 46.74557  ? 185 THR A O   1 
ATOM   1668 C CB  . THR A 1 190 ? -6.76844  17.47697 26.73071 1.000 58.62278  ? 185 THR A CB  1 
ATOM   1669 O OG1 . THR A 1 190 ? -7.60103  16.36243 27.04956 1.000 46.52413  ? 185 THR A OG1 1 
ATOM   1670 C CG2 . THR A 1 190 ? -6.73744  18.41469 27.96610 1.000 46.42290  ? 185 THR A CG2 1 
ATOM   1671 N N   . ARG A 1 191 ? -8.19213  16.76216 23.68639 1.000 42.84436  ? 186 ARG A N   1 
ATOM   1672 C CA  . ARG A 1 191 ? -8.06923  15.94096 22.48488 1.000 37.15035  ? 186 ARG A CA  1 
ATOM   1673 C C   . ARG A 1 191 ? -8.84778  16.46835 21.29914 1.000 36.95017  ? 186 ARG A C   1 
ATOM   1674 O O   . ARG A 1 191 ? -8.50897  16.09314 20.17481 1.000 37.20986  ? 186 ARG A O   1 
ATOM   1675 C CB  . ARG A 1 191 ? -8.53058  14.49426 22.76266 1.000 36.18354  ? 186 ARG A CB  1 
ATOM   1676 C CG  . ARG A 1 191 ? -8.03274  13.39478 21.79014 1.000 39.12065  ? 186 ARG A CG  1 
ATOM   1677 C CD  . ARG A 1 191 ? -8.85477  12.09292 21.94330 1.000 29.62649  ? 186 ARG A CD  1 
ATOM   1678 N NE  . ARG A 1 191 ? -10.28333 12.35726 21.79311 1.000 35.00411  ? 186 ARG A NE  1 
ATOM   1679 C CZ  . ARG A 1 191 ? -11.15453 12.33494 22.78957 1.000 31.34073  ? 186 ARG A CZ  1 
ATOM   1680 N NH1 . ARG A 1 191 ? -10.77746 11.98834 24.01642 1.000 33.87068  ? 186 ARG A NH1 1 
ATOM   1681 N NH2 . ARG A 1 191 ? -12.42967 12.67095 22.54892 1.000 28.22238  ? 186 ARG A NH2 1 
ATOM   1682 N N   . TRP A 1 192 ? -9.84601  17.35543 21.51329 1.000 31.95740  ? 187 TRP A N   1 
ATOM   1683 C CA  . TRP A 1 192 ? -10.73036 17.84440 20.43749 1.000 26.94968  ? 187 TRP A CA  1 
ATOM   1684 C C   . TRP A 1 192 ? -10.00729 18.58900 19.31455 1.000 37.39290  ? 187 TRP A C   1 
ATOM   1685 O O   . TRP A 1 192 ? -10.54043 18.69672 18.19493 1.000 32.99696  ? 187 TRP A O   1 
ATOM   1686 C CB  . TRP A 1 192 ? -11.80073 18.78218 20.99708 1.000 29.18565  ? 187 TRP A CB  1 
ATOM   1687 C CG  . TRP A 1 192 ? -12.73770 18.07622 21.94764 1.000 35.28578  ? 187 TRP A CG  1 
ATOM   1688 C CD1 . TRP A 1 192 ? -13.03112 16.74244 21.97306 1.000 32.08695  ? 187 TRP A CD1 1 
ATOM   1689 C CD2 . TRP A 1 192 ? -13.50470 18.68272 22.98422 1.000 33.11355  ? 187 TRP A CD2 1 
ATOM   1690 N NE1 . TRP A 1 192 ? -13.89874 16.46567 23.00425 1.000 35.22174  ? 187 TRP A NE1 1 
ATOM   1691 C CE2 . TRP A 1 192 ? -14.22227 17.64164 23.63109 1.000 38.60232  ? 187 TRP A CE2 1 
ATOM   1692 C CE3 . TRP A 1 192 ? -13.65354 20.00797 23.44399 1.000 40.42638  ? 187 TRP A CE3 1 
ATOM   1693 C CZ2 . TRP A 1 192 ? -15.08926 17.87954 24.69932 1.000 38.73107  ? 187 TRP A CZ2 1 
ATOM   1694 C CZ3 . TRP A 1 192 ? -14.52595 20.24474 24.51949 1.000 39.29970  ? 187 TRP A CZ3 1 
ATOM   1695 C CH2 . TRP A 1 192 ? -15.21392 19.17666 25.14308 1.000 38.57113  ? 187 TRP A CH2 1 
ATOM   1696 N N   . TYR A 1 193 ? -8.85214  19.18523 19.59188 1.000 32.57486  ? 188 TYR A N   1 
ATOM   1697 C CA  . TYR A 1 193 ? -8.17220  19.93274 18.54565 1.000 28.92697  ? 188 TYR A CA  1 
ATOM   1698 C C   . TYR A 1 193 ? -7.04647  19.15226 17.89711 1.000 37.69358  ? 188 TYR A C   1 
ATOM   1699 O O   . TYR A 1 193 ? -6.28237  19.73942 17.14412 1.000 31.81506  ? 188 TYR A O   1 
ATOM   1700 C CB  . TYR A 1 193 ? -7.63445  21.26307 19.09264 1.000 31.52670  ? 188 TYR A CB  1 
ATOM   1701 C CG  . TYR A 1 193 ? -8.78567  22.02571 19.76073 1.000 28.01252  ? 188 TYR A CG  1 
ATOM   1702 C CD1 . TYR A 1 193 ? -9.11141  21.79210 21.09791 1.000 32.68060  ? 188 TYR A CD1 1 
ATOM   1703 C CD2 . TYR A 1 193 ? -9.54192  22.95232 19.06361 1.000 33.70481  ? 188 TYR A CD2 1 
ATOM   1704 C CE1 . TYR A 1 193 ? -10.17593 22.45538 21.71467 1.000 29.97125  ? 188 TYR A CE1 1 
ATOM   1705 C CE2 . TYR A 1 193 ? -10.63659 23.63062 19.68984 1.000 31.44936  ? 188 TYR A CE2 1 
ATOM   1706 C CZ  . TYR A 1 193 ? -10.93991 23.35390 20.99731 1.000 39.54043  ? 188 TYR A CZ  1 
ATOM   1707 O OH  . TYR A 1 193 ? -11.98534 24.01025 21.61783 1.000 40.01259  ? 188 TYR A OH  1 
ATOM   1708 N N   . ARG A 1 194 ? -6.88526  17.87162 18.20058 1.000 34.41493  ? 189 ARG A N   1 
ATOM   1709 C CA  . ARG A 1 194 ? -5.71631  17.13544 17.71943 1.000 33.82543  ? 189 ARG A CA  1 
ATOM   1710 C C   . ARG A 1 194 ? -6.00242  16.48157 16.37495 1.000 31.03561  ? 189 ARG A C   1 
ATOM   1711 O O   . ARG A 1 194 ? -7.09754  15.95208 16.15270 1.000 31.10314  ? 189 ARG A O   1 
ATOM   1712 C CB  . ARG A 1 194 ? -5.30919  16.08029 18.74460 1.000 39.11613  ? 189 ARG A CB  1 
ATOM   1713 C CG  . ARG A 1 194 ? -4.33668  16.65015 19.73859 1.000 61.43932  ? 189 ARG A CG  1 
ATOM   1714 C CD  . ARG A 1 194 ? -4.22004  15.81452 20.95262 1.000 60.97262  ? 189 ARG A CD  1 
ATOM   1715 N NE  . ARG A 1 194 ? -3.13115  14.86034 20.81660 1.000 67.90210  ? 189 ARG A NE  1 
ATOM   1716 C CZ  . ARG A 1 194 ? -1.87889  15.11030 21.17238 1.000 73.34999  ? 189 ARG A CZ  1 
ATOM   1717 N NH1 . ARG A 1 194 ? -1.50954  16.30963 21.59110 1.000 68.72113  ? 189 ARG A NH1 1 
ATOM   1718 N NH2 . ARG A 1 194 ? -0.97598  14.13339 21.10521 1.000 70.70521  ? 189 ARG A NH2 1 
ATOM   1719 N N   . ALA A 1 195 ? -4.99877  16.50254 15.49497 1.000 33.29018  ? 190 ALA A N   1 
ATOM   1720 C CA  . ALA A 1 195 ? -5.12475  15.85084 14.20163 1.000 40.28855  ? 190 ALA A CA  1 
ATOM   1721 C C   . ALA A 1 195 ? -5.29183  14.34814 14.40079 1.000 35.56846  ? 190 ALA A C   1 
ATOM   1722 O O   . ALA A 1 195 ? -4.61161  13.75439 15.24882 1.000 37.58662  ? 190 ALA A O   1 
ATOM   1723 C CB  . ALA A 1 195 ? -3.89565  16.11740 13.31300 1.000 38.35230  ? 190 ALA A CB  1 
ATOM   1724 N N   . PRO A 1 196 ? -6.12501  13.69822 13.58242 1.000 35.69173  ? 191 PRO A N   1 
ATOM   1725 C CA  . PRO A 1 196 ? -6.35220  12.25585 13.75112 1.000 37.07618  ? 191 PRO A CA  1 
ATOM   1726 C C   . PRO A 1 196 ? -5.08160  11.41522 13.68460 1.000 37.84227  ? 191 PRO A C   1 
ATOM   1727 O O   . PRO A 1 196 ? -4.96315  10.43553 14.43794 1.000 44.15520  ? 191 PRO A O   1 
ATOM   1728 C CB  . PRO A 1 196 ? -7.34331  11.92131 12.62120 1.000 44.15409  ? 191 PRO A CB  1 
ATOM   1729 C CG  . PRO A 1 196 ? -7.25666  13.05754 11.66421 1.000 48.79038  ? 191 PRO A CG  1 
ATOM   1730 C CD  . PRO A 1 196 ? -6.83406  14.27406 12.42862 1.000 35.34922  ? 191 PRO A CD  1 
ATOM   1731 N N   . GLU A 1 197 ? -4.11524  11.76532 12.83299 1.000 37.34395  ? 192 GLU A N   1 
ATOM   1732 C CA  . GLU A 1 197 ? -2.90924  10.93523 12.74851 1.000 47.67987  ? 192 GLU A CA  1 
ATOM   1733 C C   . GLU A 1 197 ? -2.15790  10.90340 14.08136 1.000 47.18927  ? 192 GLU A C   1 
ATOM   1734 O O   . GLU A 1 197 ? -1.58832  9.87272  14.45584 1.000 44.97581  ? 192 GLU A O   1 
ATOM   1735 C CB  . GLU A 1 197 ? -2.00306  11.42179 11.61400 1.000 43.62697  ? 192 GLU A CB  1 
ATOM   1736 C CG  . GLU A 1 197 ? -1.40778  12.78313 11.82625 1.000 38.73264  ? 192 GLU A CG  1 
ATOM   1737 C CD  . GLU A 1 197 ? -2.21237  13.88997 11.12188 1.000 38.25895  ? 192 GLU A CD  1 
ATOM   1738 O OE1 . GLU A 1 197 ? -3.44851  13.70081 10.88630 1.000 38.71522  ? 192 GLU A OE1 1 
ATOM   1739 O OE2 . GLU A 1 197 ? -1.61103  14.96049 10.82523 1.000 39.33403  ? 192 GLU A OE2 1 
ATOM   1740 N N   A ILE A 1 198 ? -2.14670  12.01931 14.80850 0.620 38.62183  ? 193 ILE A N   1 
ATOM   1741 N N   B ILE A 1 198 ? -2.10853  12.02581 14.79930 0.380 38.82954  ? 193 ILE A N   1 
ATOM   1742 C CA  A ILE A 1 198 ? -1.58936  12.01017 16.15643 0.620 42.55052  ? 193 ILE A CA  1 
ATOM   1743 C CA  B ILE A 1 198 ? -1.57492  11.97559 16.15697 0.380 42.72087  ? 193 ILE A CA  1 
ATOM   1744 C C   A ILE A 1 198 ? -2.52904  11.27917 17.09684 0.620 50.87938  ? 193 ILE A C   1 
ATOM   1745 C C   B ILE A 1 198 ? -2.53820  11.23800 17.07159 0.380 50.78715  ? 193 ILE A C   1 
ATOM   1746 O O   A ILE A 1 198 ? -2.10581  10.45457 17.92004 0.620 51.74433  ? 193 ILE A O   1 
ATOM   1747 O O   B ILE A 1 198 ? -2.13639  10.36831 17.85602 0.380 51.75176  ? 193 ILE A O   1 
ATOM   1748 C CB  A ILE A 1 198 ? -1.34383  13.44344 16.65063 0.620 49.49560  ? 193 ILE A CB  1 
ATOM   1749 C CB  B ILE A 1 198 ? -1.28237  13.38290 16.70218 0.380 49.55387  ? 193 ILE A CB  1 
ATOM   1750 C CG1 A ILE A 1 198 ? -0.76792  14.28219 15.53238 0.620 55.32335  ? 193 ILE A CG1 1 
ATOM   1751 C CG1 B ILE A 1 198 ? -0.13667  14.04653 15.95334 0.380 56.24572  ? 193 ILE A CG1 1 
ATOM   1752 C CG2 A ILE A 1 198 ? -0.35128  13.41642 17.80573 0.620 53.79693  ? 193 ILE A CG2 1 
ATOM   1753 C CG2 B ILE A 1 198 ? -0.94006  13.31032 18.17637 0.380 57.02855  ? 193 ILE A CG2 1 
ATOM   1754 C CD1 A ILE A 1 198 ? 0.17146   13.50167 14.68831 0.620 56.28140  ? 193 ILE A CD1 1 
ATOM   1755 C CD1 B ILE A 1 198 ? 0.05593   15.50148 16.36073 0.380 61.99690  ? 193 ILE A CD1 1 
ATOM   1756 N N   . MET A 1 199 ? -3.82338  11.59381 17.00057 1.000 44.79130  ? 194 MET A N   1 
ATOM   1757 C CA  . MET A 1 199 ? -4.81253  11.00913 17.89906 1.000 52.58210  ? 194 MET A CA  1 
ATOM   1758 C C   . MET A 1 199 ? -4.75005  9.49717  17.96900 1.000 46.78455  ? 194 MET A C   1 
ATOM   1759 O O   . MET A 1 199 ? -4.81851  8.91665  19.05635 1.000 45.62878  ? 194 MET A O   1 
ATOM   1760 C CB  . MET A 1 199 ? -6.21974  11.42194 17.48311 1.000 50.13879  ? 194 MET A CB  1 
ATOM   1761 C CG  . MET A 1 199 ? -7.23076  11.07078 18.51667 1.000 46.59822  ? 194 MET A CG  1 
ATOM   1762 S SD  . MET A 1 199 ? -8.74876  11.93205 18.33473 1.000 48.55759  ? 194 MET A SD  1 
ATOM   1763 C CE  . MET A 1 199 ? -9.50724  10.85917 17.13076 1.000 49.18390  ? 194 MET A CE  1 
ATOM   1764 N N   A LEU A 1 200 ? -4.66777  8.83805  16.81415 0.590 48.04220  ? 195 LEU A N   1 
ATOM   1765 N N   B LEU A 1 200 ? -4.66748  8.84017  16.81553 0.410 48.05263  ? 195 LEU A N   1 
ATOM   1766 C CA  A LEU A 1 200 ? -4.71869  7.38319  16.72961 0.590 46.64696  ? 195 LEU A CA  1 
ATOM   1767 C CA  B LEU A 1 200 ? -4.71334  7.38731  16.73230 0.410 46.64690  ? 195 LEU A CA  1 
ATOM   1768 C C   A LEU A 1 200 ? -3.36594  6.76044  16.41450 0.590 47.11227  ? 195 LEU A C   1 
ATOM   1769 C C   B LEU A 1 200 ? -3.37925  6.77873  16.32697 0.410 47.16677  ? 195 LEU A C   1 
ATOM   1770 O O   A LEU A 1 200 ? -3.29256  5.54716  16.19237 0.590 52.86280  ? 195 LEU A O   1 
ATOM   1771 O O   B LEU A 1 200 ? -3.33099  5.59795  15.96412 0.410 52.05856  ? 195 LEU A O   1 
ATOM   1772 C CB  A LEU A 1 200 ? -5.73465  6.93310  15.67592 0.590 43.47543  ? 195 LEU A CB  1 
ATOM   1773 C CB  B LEU A 1 200 ? -5.80898  6.94747  15.76064 0.410 43.72036  ? 195 LEU A CB  1 
ATOM   1774 C CG  A LEU A 1 200 ? -7.20717  7.13460  16.03702 0.590 52.49537  ? 195 LEU A CG  1 
ATOM   1775 C CG  B LEU A 1 200 ? -7.13626  7.66658  16.00886 0.410 51.78005  ? 195 LEU A CG  1 
ATOM   1776 C CD1 A LEU A 1 200 ? -7.39128  7.24746  17.54589 0.590 46.04709  ? 195 LEU A CD1 1 
ATOM   1777 C CD1 B LEU A 1 200 ? -7.79500  8.09788  14.70450 0.410 49.05217  ? 195 LEU A CD1 1 
ATOM   1778 C CD2 A LEU A 1 200 ? -7.76850  8.35534  15.33213 0.590 53.38753  ? 195 LEU A CD2 1 
ATOM   1779 C CD2 B LEU A 1 200 ? -8.07606  6.80379  16.83590 0.410 50.25551  ? 195 LEU A CD2 1 
ATOM   1780 N N   . ASN A 1 201 ? -2.29680  7.55403  16.37357 1.000 46.56700  ? 196 ASN A N   1 
ATOM   1781 C CA  . ASN A 1 201 ? -0.94426  7.02893  16.13984 1.000 46.51870  ? 196 ASN A CA  1 
ATOM   1782 C C   . ASN A 1 201 ? -0.84457  6.34385  14.76811 1.000 57.42484  ? 196 ASN A C   1 
ATOM   1783 O O   . ASN A 1 201 ? -0.34465  5.22521  14.63252 1.000 56.44196  ? 196 ASN A O   1 
ATOM   1784 C CB  . ASN A 1 201 ? -0.53749  6.07753  17.27652 1.000 41.63254  ? 196 ASN A CB  1 
ATOM   1785 C CG  . ASN A 1 201 ? 0.96841   5.86154  17.36314 1.000 73.80914  ? 196 ASN A CG  1 
ATOM   1786 O OD1 . ASN A 1 201 ? 1.75284   6.58025  16.73753 1.000 84.37162  ? 196 ASN A OD1 1 
ATOM   1787 N ND2 . ASN A 1 201 ? 1.37594   4.83565  18.10668 1.000 70.32858  ? 196 ASN A ND2 1 
ATOM   1788 N N   . TRP A 1 202 ? -1.32821  7.03246  13.73182 1.000 46.57489  ? 197 TRP A N   1 
ATOM   1789 C CA  . TRP A 1 202 ? -1.35410  6.43632  12.40146 1.000 43.61618  ? 197 TRP A CA  1 
ATOM   1790 C C   . TRP A 1 202 ? 0.02224   6.36272  11.77906 1.000 47.43198  ? 197 TRP A C   1 
ATOM   1791 O O   . TRP A 1 202 ? 0.38021   5.35864  11.15262 1.000 50.47417  ? 197 TRP A O   1 
ATOM   1792 C CB  . TRP A 1 202 ? -2.27190  7.22242  11.47396 1.000 50.85876  ? 197 TRP A CB  1 
ATOM   1793 C CG  . TRP A 1 202 ? -3.69653  6.98959  11.68602 1.000 53.56967  ? 197 TRP A CG  1 
ATOM   1794 C CD1 . TRP A 1 202 ? -4.27558  6.03195  12.48321 1.000 45.94629  ? 197 TRP A CD1 1 
ATOM   1795 C CD2 . TRP A 1 202 ? -4.76382  7.68127  11.03481 1.000 46.64356  ? 197 TRP A CD2 1 
ATOM   1796 N NE1 . TRP A 1 202 ? -5.65567  6.11404  12.38427 1.000 48.20799  ? 197 TRP A NE1 1 
ATOM   1797 C CE2 . TRP A 1 202 ? -5.97640  7.11460  11.50137 1.000 47.13919  ? 197 TRP A CE2 1 
ATOM   1798 C CE3 . TRP A 1 202 ? -4.81495  8.73797  10.11364 1.000 42.59631  ? 197 TRP A CE3 1 
ATOM   1799 C CZ2 . TRP A 1 202 ? -7.22927  7.56579  11.07449 1.000 51.06364  ? 197 TRP A CZ2 1 
ATOM   1800 C CZ3 . TRP A 1 202 ? -6.07750  9.19431  9.70395  1.000 47.72311  ? 197 TRP A CZ3 1 
ATOM   1801 C CH2 . TRP A 1 202 ? -7.25596  8.60003  10.18465 1.000 47.62319  ? 197 TRP A CH2 1 
ATOM   1802 N N   A MET A 1 203 ? 0.78126   7.44675  11.87309 0.480 53.74310  ? 198 MET A N   1 
ATOM   1803 N N   B MET A 1 203 ? 0.81022   7.41444  11.94371 0.520 53.70449  ? 198 MET A N   1 
ATOM   1804 C CA  A MET A 1 203 ? 2.06205   7.53048  11.19799 0.480 61.54301  ? 198 MET A CA  1 
ATOM   1805 C CA  B MET A 1 203 ? 2.05871   7.54612  11.21751 0.520 61.54450  ? 198 MET A CA  1 
ATOM   1806 C C   A MET A 1 203 ? 2.96444   8.46608  11.98797 0.480 63.10851  ? 198 MET A C   1 
ATOM   1807 C C   B MET A 1 203 ? 2.96741   8.47863  11.99609 0.520 63.11428  ? 198 MET A C   1 
ATOM   1808 O O   A MET A 1 203 ? 2.55184   9.07717  12.98059 0.480 58.08841  ? 198 MET A O   1 
ATOM   1809 O O   B MET A 1 203 ? 2.55807   9.10597  12.97884 0.520 58.06680  ? 198 MET A O   1 
ATOM   1810 C CB  A MET A 1 203 ? 1.92818   8.05437  9.76323  0.480 62.34599  ? 198 MET A CB  1 
ATOM   1811 C CB  B MET A 1 203 ? 1.82794   8.10079  9.81012  0.520 62.35787  ? 198 MET A CB  1 
ATOM   1812 C CG  A MET A 1 203 ? 1.37407   9.46902  9.67567  0.480 66.47472  ? 198 MET A CG  1 
ATOM   1813 C CG  B MET A 1 203 ? 0.99856   9.37275  9.81350  0.520 66.28953  ? 198 MET A CG  1 
ATOM   1814 S SD  A MET A 1 203 ? 0.22827   9.70301  8.32026  0.480 67.24328  ? 198 MET A SD  1 
ATOM   1815 S SD  B MET A 1 203 ? -0.06482  9.48129  8.38523  0.520 68.92166  ? 198 MET A SD  1 
ATOM   1816 C CE  A MET A 1 203 ? -0.85924  8.29520  8.53913  0.480 60.78478  ? 198 MET A CE  1 
ATOM   1817 C CE  B MET A 1 203 ? 1.16707   9.58785  7.10174  0.520 62.86750  ? 198 MET A CE  1 
ATOM   1818 N N   . HIS A 1 204 ? 4.20621   8.58015  11.52464 1.000 60.44523  ? 199 HIS A N   1 
ATOM   1819 C CA  . HIS A 1 204 ? 5.09453   9.61396  12.01899 1.000 70.99604  ? 199 HIS A CA  1 
ATOM   1820 C C   . HIS A 1 204 ? 4.49737   10.96098 11.63757 1.000 72.24424  ? 199 HIS A C   1 
ATOM   1821 O O   . HIS A 1 204 ? 4.16720   11.20166 10.47024 1.000 65.99254  ? 199 HIS A O   1 
ATOM   1822 C CB  . HIS A 1 204 ? 6.48550   9.44910  11.41046 1.000 79.05460  ? 199 HIS A CB  1 
ATOM   1823 C CG  . HIS A 1 204 ? 7.27158   8.32017  12.00525 1.000 99.31887  ? 199 HIS A CG  1 
ATOM   1824 N ND1 . HIS A 1 204 ? 6.88004   7.66083  13.15235 1.000 102.96788 ? 199 HIS A ND1 1 
ATOM   1825 C CD2 . HIS A 1 204 ? 8.41502   7.71837  11.59826 1.000 101.21222 ? 199 HIS A CD2 1 
ATOM   1826 C CE1 . HIS A 1 204 ? 7.75346   6.70900  13.43067 1.000 100.80048 ? 199 HIS A CE1 1 
ATOM   1827 N NE2 . HIS A 1 204 ? 8.69485   6.72318  12.50364 1.000 102.07126 ? 199 HIS A NE2 1 
ATOM   1828 N N   . TYR A 1 205 ? 4.32683   11.82580 12.62016 1.000 62.51289  ? 200 TYR A N   1 
ATOM   1829 C CA  . TYR A 1 205 ? 3.70352   13.11319 12.37814 1.000 62.97611  ? 200 TYR A CA  1 
ATOM   1830 C C   . TYR A 1 205 ? 4.73986   14.21271 12.20635 1.000 61.91146  ? 200 TYR A C   1 
ATOM   1831 O O   . TYR A 1 205 ? 5.92656   14.04799 12.49706 1.000 57.99976  ? 200 TYR A O   1 
ATOM   1832 C CB  . TYR A 1 205 ? 2.75498   13.46016 13.51121 1.000 59.45758  ? 200 TYR A CB  1 
ATOM   1833 C CG  . TYR A 1 205 ? 3.44735   13.78709 14.79450 1.000 54.93542  ? 200 TYR A CG  1 
ATOM   1834 C CD1 . TYR A 1 205 ? 3.91828   12.77725 15.61761 1.000 71.67243  ? 200 TYR A CD1 1 
ATOM   1835 C CD2 . TYR A 1 205 ? 3.64001   15.10239 15.18949 1.000 61.89985  ? 200 TYR A CD2 1 
ATOM   1836 C CE1 . TYR A 1 205 ? 4.55174   13.06796 16.81467 1.000 78.20449  ? 200 TYR A CE1 1 
ATOM   1837 C CE2 . TYR A 1 205 ? 4.27203   15.40638 16.38440 1.000 68.77567  ? 200 TYR A CE2 1 
ATOM   1838 C CZ  . TYR A 1 205 ? 4.72105   14.37943 17.19253 1.000 75.20640  ? 200 TYR A CZ  1 
ATOM   1839 O OH  . TYR A 1 205 ? 5.35471   14.65880 18.37847 1.000 86.67896  ? 200 TYR A OH  1 
ATOM   1840 N N   . ASN A 1 206 ? 4.25950   15.35232 11.72575 1.000 44.36200  ? 201 ASN A N   1 
ATOM   1841 C CA  . ASN A 1 206 ? 5.08411   16.50982 11.40444 1.000 49.98919  ? 201 ASN A CA  1 
ATOM   1842 C C   . ASN A 1 206 ? 4.27278   17.78481 11.63747 1.000 44.43343  ? 201 ASN A C   1 
ATOM   1843 O O   . ASN A 1 206 ? 3.20069   17.75382 12.24284 1.000 39.78514  ? 201 ASN A O   1 
ATOM   1844 C CB  . ASN A 1 206 ? 5.63959   16.33389 9.98818  1.000 60.46285  ? 201 ASN A CB  1 
ATOM   1845 C CG  . ASN A 1 206 ? 4.56701   16.50277 8.92155  1.000 53.23081  ? 201 ASN A CG  1 
ATOM   1846 O OD1 . ASN A 1 206 ? 3.66583   17.32858 9.03555  1.000 56.39824  ? 201 ASN A OD1 1 
ATOM   1847 N ND2 . ASN A 1 206 ? 4.64759   15.66962 7.88274  1.000 61.59290  ? 201 ASN A ND2 1 
ATOM   1848 N N   . GLN A 1 207 ? 4.77740   18.91564 11.14010 1.000 45.69389  ? 202 GLN A N   1 
ATOM   1849 C CA  . GLN A 1 207 ? 4.24343   20.19336 11.59392 1.000 46.36322  ? 202 GLN A CA  1 
ATOM   1850 C C   . GLN A 1 207 ? 2.81145   20.40047 11.12807 1.000 35.42857  ? 202 GLN A C   1 
ATOM   1851 O O   . GLN A 1 207 ? 2.12673   21.27956 11.66728 1.000 31.97787  ? 202 GLN A O   1 
ATOM   1852 C CB  . GLN A 1 207 ? 5.09425   21.33838 11.07609 1.000 38.90067  ? 202 GLN A CB  1 
ATOM   1853 C CG  . GLN A 1 207 ? 5.43141   21.21688 9.63624  1.000 47.67621  ? 202 GLN A CG  1 
ATOM   1854 C CD  . GLN A 1 207 ? 6.22610   22.40254 9.17770  1.000 48.58992  ? 202 GLN A CD  1 
ATOM   1855 O OE1 . GLN A 1 207 ? 7.30438   22.62894 9.71654  1.000 41.21431  ? 202 GLN A OE1 1 
ATOM   1856 N NE2 . GLN A 1 207 ? 5.70960   23.18009 8.22261  1.000 39.80241  ? 202 GLN A NE2 1 
ATOM   1857 N N   . THR A 1 208 ? 2.33538   19.59593 10.16153 1.000 37.90479  ? 203 THR A N   1 
ATOM   1858 C CA  . THR A 1 208 ? 0.97609   19.76320 9.63001  1.000 45.29236  ? 203 THR A CA  1 
ATOM   1859 C C   . THR A 1 208 ? -0.10253  19.44031 10.66718 1.000 33.28415  ? 203 THR A C   1 
ATOM   1860 O O   . THR A 1 208 ? -1.26915  19.82106 10.48229 1.000 33.34829  ? 203 THR A O   1 
ATOM   1861 C CB  . THR A 1 208 ? 0.81223   18.89302 8.36731  1.000 46.52927  ? 203 THR A CB  1 
ATOM   1862 O OG1 . THR A 1 208 ? 1.12799   17.53275 8.69639  1.000 41.96074  ? 203 THR A OG1 1 
ATOM   1863 C CG2 . THR A 1 208 ? 1.79301   19.33341 7.28912  1.000 45.74742  ? 203 THR A CG2 1 
ATOM   1864 N N   . VAL A 1 209 ? 0.25888   18.77072 11.77232 1.000 36.67290  ? 204 VAL A N   1 
ATOM   1865 C CA  . VAL A 1 209 ? -0.71429  18.59479 12.84877 1.000 38.80351  ? 204 VAL A CA  1 
ATOM   1866 C C   . VAL A 1 209 ? -1.19406  19.93498 13.37583 1.000 34.06526  ? 204 VAL A C   1 
ATOM   1867 O O   . VAL A 1 209 ? -2.35423  20.07013 13.74496 1.000 32.87195  ? 204 VAL A O   1 
ATOM   1868 C CB  . VAL A 1 209 ? -0.15335  17.73488 13.98649 1.000 37.79565  ? 204 VAL A CB  1 
ATOM   1869 C CG1 . VAL A 1 209 ? 0.25050   16.36107 13.44162 1.000 43.68567  ? 204 VAL A CG1 1 
ATOM   1870 C CG2 . VAL A 1 209 ? 1.01219   18.45199 14.62567 1.000 30.57694  ? 204 VAL A CG2 1 
ATOM   1871 N N   . ASP A 1 210 ? -0.30712  20.92364 13.47435 1.000 29.15050  ? 205 ASP A N   1 
ATOM   1872 C CA  . ASP A 1 210 ? -0.70819  22.22595 13.99023 1.000 28.32212  ? 205 ASP A CA  1 
ATOM   1873 C C   . ASP A 1 210 ? -1.74426  22.89581 13.09047 1.000 35.65000  ? 205 ASP A C   1 
ATOM   1874 O O   . ASP A 1 210 ? -2.60682  23.61483 13.58323 1.000 32.96098  ? 205 ASP A O   1 
ATOM   1875 C CB  . ASP A 1 210 ? 0.51231   23.14767 14.10811 1.000 27.84162  ? 205 ASP A CB  1 
ATOM   1876 C CG  . ASP A 1 210 ? 1.46907   22.74750 15.21624 1.000 38.99874  ? 205 ASP A CG  1 
ATOM   1877 O OD1 . ASP A 1 210 ? 1.04734   22.10863 16.21417 1.000 40.46764  ? 205 ASP A OD1 1 
ATOM   1878 O OD2 . ASP A 1 210 ? 2.65363   23.09528 15.06113 1.000 36.41449  ? 205 ASP A OD2 1 
ATOM   1879 N N   . ILE A 1 211 ? -1.66512  22.70975 11.76854 1.000 34.63777  ? 206 ILE A N   1 
ATOM   1880 C CA  . ILE A 1 211 ? -2.67273  23.32652 10.90584 1.000 32.59277  ? 206 ILE A CA  1 
ATOM   1881 C C   . ILE A 1 211 ? -4.04920  22.68221 11.12821 1.000 31.27049  ? 206 ILE A C   1 
ATOM   1882 O O   . ILE A 1 211 ? -5.08740  23.35420 11.05547 1.000 31.97933  ? 206 ILE A O   1 
ATOM   1883 C CB  . ILE A 1 211 ? -2.23743  23.21622 9.43440  1.000 32.56028  ? 206 ILE A CB  1 
ATOM   1884 C CG1 . ILE A 1 211 ? -0.95072  24.01712 9.20438  1.000 33.40090  ? 206 ILE A CG1 1 
ATOM   1885 C CG2 . ILE A 1 211 ? -3.40095  23.68523 8.53649  1.000 33.04522  ? 206 ILE A CG2 1 
ATOM   1886 C CD1 . ILE A 1 211 ? -1.14498  25.51925 9.29128  1.000 47.71075  ? 206 ILE A CD1 1 
ATOM   1887 N N   . TRP A 1 212 ? -4.09742  21.37576 11.38519 1.000 35.10606  ? 207 TRP A N   1 
ATOM   1888 C CA  . TRP A 1 212 ? -5.39237  20.79037 11.73139 1.000 32.49165  ? 207 TRP A CA  1 
ATOM   1889 C C   . TRP A 1 212 ? -5.98676  21.50301 12.93165 1.000 30.47074  ? 207 TRP A C   1 
ATOM   1890 O O   . TRP A 1 212 ? -7.17109  21.88384 12.94247 1.000 30.85814  ? 207 TRP A O   1 
ATOM   1891 C CB  . TRP A 1 212 ? -5.26077  19.29275 12.01721 1.000 29.60173  ? 207 TRP A CB  1 
ATOM   1892 C CG  . TRP A 1 212 ? -6.61913  18.63047 12.33683 1.000 28.21156  ? 207 TRP A CG  1 
ATOM   1893 C CD1 . TRP A 1 212 ? -7.26279  18.62129 13.55017 1.000 29.83127  ? 207 TRP A CD1 1 
ATOM   1894 C CD2 . TRP A 1 212 ? -7.49628  17.94911 11.41436 1.000 31.98308  ? 207 TRP A CD2 1 
ATOM   1895 N NE1 . TRP A 1 212 ? -8.46393  17.93686 13.44884 1.000 30.69518  ? 207 TRP A NE1 1 
ATOM   1896 C CE2 . TRP A 1 212 ? -8.64351  17.54078 12.14337 1.000 29.96343  ? 207 TRP A CE2 1 
ATOM   1897 C CE3 . TRP A 1 212 ? -7.41525  17.63609 10.05195 1.000 36.06219  ? 207 TRP A CE3 1 
ATOM   1898 C CZ2 . TRP A 1 212 ? -9.69611  16.81069 11.55652 1.000 31.61262  ? 207 TRP A CZ2 1 
ATOM   1899 C CZ3 . TRP A 1 212 ? -8.44817  16.93404 9.46736  1.000 34.58967  ? 207 TRP A CZ3 1 
ATOM   1900 C CH2 . TRP A 1 212 ? -9.58309  16.51135 10.21847 1.000 33.20885  ? 207 TRP A CH2 1 
ATOM   1901 N N   . SER A 1 213 ? -5.16119  21.73770 13.93571 1.000 29.86139  ? 208 SER A N   1 
ATOM   1902 C CA  . SER A 1 213 ? -5.66969  22.39568 15.13166 1.000 29.10898  ? 208 SER A CA  1 
ATOM   1903 C C   . SER A 1 213 ? -6.20837  23.77953 14.80732 1.000 37.13314  ? 208 SER A C   1 
ATOM   1904 O O   . SER A 1 213 ? -7.29881  24.15648 15.25950 1.000 33.35373  ? 208 SER A O   1 
ATOM   1905 C CB  . SER A 1 213 ? -4.58359  22.46903 16.17099 1.000 31.17295  ? 208 SER A CB  1 
ATOM   1906 O OG  . SER A 1 213 ? -4.09026  21.18257 16.41438 1.000 34.72284  ? 208 SER A OG  1 
ATOM   1907 N N   . VAL A 1 214 ? -5.47828  24.54506 14.00383 1.000 27.97715  ? 209 VAL A N   1 
ATOM   1908 C CA  . VAL A 1 214 ? -5.96901  25.86051 13.61094 1.000 32.55781  ? 209 VAL A CA  1 
ATOM   1909 C C   . VAL A 1 214 ? -7.33950  25.76854 12.93155 1.000 30.44945  ? 209 VAL A C   1 
ATOM   1910 O O   . VAL A 1 214 ? -8.19431  26.65201 13.10083 1.000 33.15607  ? 209 VAL A O   1 
ATOM   1911 C CB  . VAL A 1 214 ? -4.93718  26.55107 12.70301 1.000 27.64461  ? 209 VAL A CB  1 
ATOM   1912 C CG1 . VAL A 1 214 ? -5.51730  27.87622 12.25033 1.000 32.70784  ? 209 VAL A CG1 1 
ATOM   1913 C CG2 . VAL A 1 214 ? -3.54848  26.73151 13.46787 1.000 29.65222  ? 209 VAL A CG2 1 
ATOM   1914 N N   . GLY A 1 215 ? -7.53611  24.76042 12.07847 1.000 32.87138  ? 210 GLY A N   1 
ATOM   1915 C CA  . GLY A 1 215 ? -8.84765  24.58254 11.46272 1.000 36.42277  ? 210 GLY A CA  1 
ATOM   1916 C C   . GLY A 1 215 ? -9.94286  24.36743 12.48821 1.000 34.62261  ? 210 GLY A C   1 
ATOM   1917 O O   . GLY A 1 215 ? -11.04806 24.90035 12.34556 1.000 34.64599  ? 210 GLY A O   1 
ATOM   1918 N N   . CYS A 1 216 ? -9.65397  23.59507 13.55197 1.000 33.06264  ? 211 CYS A N   1 
ATOM   1919 C CA  . CYS A 1 216 ? -10.66143 23.34640 14.58276 1.000 33.77215  ? 211 CYS A CA  1 
ATOM   1920 C C   . CYS A 1 216 ? -10.94448 24.63362 15.34303 1.000 37.65685  ? 211 CYS A C   1 
ATOM   1921 O O   . CYS A 1 216 ? -12.09236 24.93977 15.67542 1.000 35.69781  ? 211 CYS A O   1 
ATOM   1922 C CB  . CYS A 1 216 ? -10.16247 22.27503 15.56659 1.000 29.36159  ? 211 CYS A CB  1 
ATOM   1923 S SG  . CYS A 1 216 ? -9.91197  20.69842 14.73393 1.000 33.23701  ? 211 CYS A SG  1 
ATOM   1924 N N   A ILE A 1 217 ? -9.89300  25.39467 15.63739 0.720 34.40270  ? 212 ILE A N   1 
ATOM   1925 N N   B ILE A 1 217 ? -9.90272  25.41851 15.62124 0.280 34.35495  ? 212 ILE A N   1 
ATOM   1926 C CA  A ILE A 1 217 ? -10.06205 26.64404 16.36291 0.720 30.35828  ? 212 ILE A CA  1 
ATOM   1927 C CA  B ILE A 1 217 ? -10.10606 26.63856 16.39216 0.280 30.68193  ? 212 ILE A CA  1 
ATOM   1928 C C   A ILE A 1 217 ? -10.85213 27.62766 15.51994 0.720 35.37649  ? 212 ILE A C   1 
ATOM   1929 C C   B ILE A 1 217 ? -10.80732 27.69178 15.54643 0.280 35.35981  ? 212 ILE A C   1 
ATOM   1930 O O   A ILE A 1 217 ? -11.82236 28.23985 15.97879 0.720 37.47523  ? 212 ILE A O   1 
ATOM   1931 O O   B ILE A 1 217 ? -11.67285 28.42667 16.03667 0.280 36.84480  ? 212 ILE A O   1 
ATOM   1932 C CB  A ILE A 1 217 ? -8.68789  27.22111 16.74812 0.720 29.74635  ? 212 ILE A CB  1 
ATOM   1933 C CB  B ILE A 1 217 ? -8.76898  27.15862 16.94792 0.280 30.84101  ? 212 ILE A CB  1 
ATOM   1934 C CG1 A ILE A 1 217 ? -8.03920  26.39629 17.86833 0.720 34.73114  ? 212 ILE A CG1 1 
ATOM   1935 C CG1 B ILE A 1 217 ? -7.84815  27.62061 15.82127 0.280 32.59827  ? 212 ILE A CG1 1 
ATOM   1936 C CG2 A ILE A 1 217 ? -8.81993  28.66701 17.17665 0.720 29.49845  ? 212 ILE A CG2 1 
ATOM   1937 C CG2 B ILE A 1 217 ? -8.07979  26.07686 17.77961 0.280 32.83410  ? 212 ILE A CG2 1 
ATOM   1938 C CD1 A ILE A 1 217 ? -6.53899  26.56244 17.93070 0.720 28.71128  ? 212 ILE A CD1 1 
ATOM   1939 C CD1 B ILE A 1 217 ? -6.35890  27.65238 16.25322 0.280 36.39688  ? 212 ILE A CD1 1 
ATOM   1940 N N   . MET A 1 218 ? -10.45588 27.78815 14.26441 1.000 31.46707  ? 213 MET A N   1 
ATOM   1941 C CA  . MET A 1 218 ? -11.18303 28.70704 13.39469 1.000 31.21090  ? 213 MET A CA  1 
ATOM   1942 C C   . MET A 1 218 ? -12.67494 28.36877 13.33074 1.000 38.22899  ? 213 MET A C   1 
ATOM   1943 O O   . MET A 1 218 ? -13.53863 29.25918 13.40373 1.000 36.42348  ? 213 MET A O   1 
ATOM   1944 C CB  . MET A 1 218 ? -10.60457 28.67799 11.99273 1.000 31.22105  ? 213 MET A CB  1 
ATOM   1945 C CG  . MET A 1 218 ? -11.31203 29.70889 11.07503 1.000 35.95755  ? 213 MET A CG  1 
ATOM   1946 S SD  . MET A 1 218 ? -10.36674 29.82446 9.54437  1.000 42.43546  ? 213 MET A SD  1 
ATOM   1947 C CE  . MET A 1 218 ? -11.48815 30.71105 8.45059  1.000 44.06435  ? 213 MET A CE  1 
ATOM   1948 N N   . ALA A 1 219 ? -12.99715 27.10134 13.08011 1.000 29.28508  ? 214 ALA A N   1 
ATOM   1949 C CA  . ALA A 1 219 ? -14.40064 26.70760 13.02426 1.000 33.75261  ? 214 ALA A CA  1 
ATOM   1950 C C   . ALA A 1 219 ? -15.12842 27.08441 14.30834 1.000 35.05729  ? 214 ALA A C   1 
ATOM   1951 O O   . ALA A 1 219 ? -16.30369 27.47077 14.28304 1.000 36.57870  ? 214 ALA A O   1 
ATOM   1952 C CB  . ALA A 1 219 ? -14.52267 25.20426 12.78098 1.000 34.43817  ? 214 ALA A CB  1 
ATOM   1953 N N   . GLU A 1 220 ? -14.45430 26.94733 15.44584 1.000 39.05769  ? 215 GLU A N   1 
ATOM   1954 C CA  . GLU A 1 220 ? -15.11181 27.23779 16.70531 1.000 39.81778  ? 215 GLU A CA  1 
ATOM   1955 C C   . GLU A 1 220 ? -15.31415 28.73340 16.88462 1.000 42.04616  ? 215 GLU A C   1 
ATOM   1956 O O   . GLU A 1 220 ? -16.30091 29.15165 17.49084 1.000 39.80113  ? 215 GLU A O   1 
ATOM   1957 C CB  . GLU A 1 220 ? -14.28483 26.65624 17.85377 1.000 38.73392  ? 215 GLU A CB  1 
ATOM   1958 C CG  . GLU A 1 220 ? -14.98395 26.74285 19.17319 1.000 37.90048  ? 215 GLU A CG  1 
ATOM   1959 C CD  . GLU A 1 220 ? -14.24079 26.06245 20.31328 1.000 54.00168  ? 215 GLU A CD  1 
ATOM   1960 O OE1 . GLU A 1 220 ? -14.28111 26.59144 21.44015 1.000 46.13974  ? 215 GLU A OE1 1 
ATOM   1961 O OE2 . GLU A 1 220 ? -13.60921 24.99390 20.05533 1.000 46.58699  ? 215 GLU A OE2 1 
ATOM   1962 N N   . LEU A 1 221 ? -14.37549 29.54986 16.40091 1.000 33.34970  ? 216 LEU A N   1 
ATOM   1963 C CA  . LEU A 1 221 ? -14.56668 30.99797 16.42912 1.000 40.97008  ? 216 LEU A CA  1 
ATOM   1964 C C   . LEU A 1 221 ? -15.76682 31.40394 15.59043 1.000 42.22868  ? 216 LEU A C   1 
ATOM   1965 O O   . LEU A 1 221 ? -16.51082 32.32392 15.95572 1.000 35.69095  ? 216 LEU A O   1 
ATOM   1966 C CB  . LEU A 1 221 ? -13.30727 31.69044 15.91523 1.000 40.53455  ? 216 LEU A CB  1 
ATOM   1967 C CG  . LEU A 1 221 ? -12.13484 31.59575 16.89520 1.000 41.22379  ? 216 LEU A CG  1 
ATOM   1968 C CD1 . LEU A 1 221 ? -10.99622 32.44990 16.42928 1.000 44.97159  ? 216 LEU A CD1 1 
ATOM   1969 C CD2 . LEU A 1 221 ? -12.56857 31.97675 18.31859 1.000 49.62788  ? 216 LEU A CD2 1 
ATOM   1970 N N   . LEU A 1 222 ? -15.96697 30.72317 14.46045 1.000 37.32255  ? 217 LEU A N   1 
ATOM   1971 C CA  . LEU A 1 222 ? -17.04325 31.08086 13.53814 1.000 36.82389  ? 217 LEU A CA  1 
ATOM   1972 C C   . LEU A 1 222 ? -18.40984 30.63383 14.03400 1.000 43.29697  ? 217 LEU A C   1 
ATOM   1973 O O   . LEU A 1 222 ? -19.40901 31.31188 13.78649 1.000 43.67989  ? 217 LEU A O   1 
ATOM   1974 C CB  . LEU A 1 222 ? -16.78675 30.46139 12.17464 1.000 43.83939  ? 217 LEU A CB  1 
ATOM   1975 C CG  . LEU A 1 222 ? -15.48694 30.92119 11.53424 1.000 43.85316  ? 217 LEU A CG  1 
ATOM   1976 C CD1 . LEU A 1 222 ? -15.25984 30.21500 10.19328 1.000 43.11949  ? 217 LEU A CD1 1 
ATOM   1977 C CD2 . LEU A 1 222 ? -15.55910 32.44136 11.38240 1.000 51.34357  ? 217 LEU A CD2 1 
ATOM   1978 N N   . THR A 1 223 ? -18.48138 29.48276 14.69439 1.000 34.46588  ? 218 THR A N   1 
ATOM   1979 C CA  . THR A 1 223 ? -19.75272 28.92939 15.13661 1.000 39.02588  ? 218 THR A CA  1 
ATOM   1980 C C   . THR A 1 223 ? -20.00070 29.15295 16.60810 1.000 44.35160  ? 218 THR A C   1 
ATOM   1981 O O   . THR A 1 223 ? -21.15349 29.04930 17.04154 1.000 41.30027  ? 218 THR A O   1 
ATOM   1982 C CB  . THR A 1 223 ? -19.81327 27.41426 14.92484 1.000 43.19700  ? 218 THR A CB  1 
ATOM   1983 O OG1 . THR A 1 223 ? -18.84663 26.79999 15.79899 1.000 37.68569  ? 218 THR A OG1 1 
ATOM   1984 C CG2 . THR A 1 223 ? -19.54251 27.05160 13.46724 1.000 49.94952  ? 218 THR A CG2 1 
ATOM   1985 N N   . GLY A 1 224 ? -18.94904 29.41411 17.38215 1.000 41.35655  ? 219 GLY A N   1 
ATOM   1986 C CA  . GLY A 1 224 ? -19.05063 29.36248 18.82419 1.000 40.86914  ? 219 GLY A CA  1 
ATOM   1987 C C   . GLY A 1 224 ? -19.12432 27.97184 19.42755 1.000 45.08474  ? 219 GLY A C   1 
ATOM   1988 O O   . GLY A 1 224 ? -19.28513 27.86380 20.64244 1.000 47.06394  ? 219 GLY A O   1 
ATOM   1989 N N   . ARG A 1 225 ? -18.97906 26.90264 18.63396 1.000 36.53120  ? 220 ARG A N   1 
ATOM   1990 C CA  . ARG A 1 225 ? -19.12841 25.52832 19.11345 1.000 35.39062  ? 220 ARG A CA  1 
ATOM   1991 C C   . ARG A 1 225 ? -17.90623 24.70236 18.74011 1.000 40.87393  ? 220 ARG A C   1 
ATOM   1992 O O   . ARG A 1 225 ? -17.32463 24.88376 17.66882 1.000 33.15609  ? 220 ARG A O   1 
ATOM   1993 C CB  . ARG A 1 225 ? -20.37717 24.80142 18.51288 1.000 38.97705  ? 220 ARG A CB  1 
ATOM   1994 C CG  . ARG A 1 225 ? -21.72144 25.54773 18.67065 1.000 39.03822  ? 220 ARG A CG  1 
ATOM   1995 C CD  . ARG A 1 225 ? -22.05410 25.60232 20.15678 1.000 45.11585  ? 220 ARG A CD  1 
ATOM   1996 N NE  . ARG A 1 225 ? -23.12220 26.54721 20.44693 1.000 51.29053  ? 220 ARG A NE  1 
ATOM   1997 C CZ  . ARG A 1 225 ? -23.52469 26.86357 21.67272 1.000 43.78405  ? 220 ARG A CZ  1 
ATOM   1998 N NH1 . ARG A 1 225 ? -23.01182 26.27731 22.74445 1.000 47.08336  ? 220 ARG A NH1 1 
ATOM   1999 N NH2 . ARG A 1 225 ? -24.40908 27.84410 21.82891 1.000 50.09129  ? 220 ARG A NH2 1 
ATOM   2000 N N   . THR A 1 226 ? -17.56204 23.73703 19.58597 1.000 36.01405  ? 221 THR A N   1 
ATOM   2001 C CA  . THR A 1 226 ? -16.44228 22.84787 19.25794 1.000 33.30500  ? 221 THR A CA  1 
ATOM   2002 C C   . THR A 1 226 ? -16.72748 22.11440 17.96276 1.000 34.05284  ? 221 THR A C   1 
ATOM   2003 O O   . THR A 1 226 ? -17.83011 21.60116 17.76497 1.000 36.60268  ? 221 THR A O   1 
ATOM   2004 C CB  . THR A 1 226 ? -16.22746 21.82700 20.37990 1.000 40.58631  ? 221 THR A CB  1 
ATOM   2005 O OG1 . THR A 1 226 ? -16.31184 22.49368 21.65435 1.000 43.45454  ? 221 THR A OG1 1 
ATOM   2006 C CG2 . THR A 1 226 ? -14.89570 21.10570 20.22531 1.000 36.94612  ? 221 THR A CG2 1 
ATOM   2007 N N   . LEU A 1 227 ? -15.72481 22.02259 17.08040 1.000 30.79130  ? 222 LEU A N   1 
ATOM   2008 C CA  . LEU A 1 227 ? -16.00656 21.35341 15.81191 1.000 33.55443  ? 222 LEU A CA  1 
ATOM   2009 C C   . LEU A 1 227 ? -16.17113 19.83933 16.01921 1.000 30.11686  ? 222 LEU A C   1 
ATOM   2010 O O   . LEU A 1 227 ? -17.12086 19.22805 15.50185 1.000 32.40958  ? 222 LEU A O   1 
ATOM   2011 C CB  . LEU A 1 227 ? -14.90462 21.67465 14.79558 1.000 32.13741  ? 222 LEU A CB  1 
ATOM   2012 C CG  . LEU A 1 227 ? -15.04324 21.04897 13.40826 1.000 34.69242  ? 222 LEU A CG  1 
ATOM   2013 C CD1 . LEU A 1 227 ? -16.38177 21.45470 12.80796 1.000 29.69092  ? 222 LEU A CD1 1 
ATOM   2014 C CD2 . LEU A 1 227 ? -13.90731 21.51145 12.50586 1.000 34.06782  ? 222 LEU A CD2 1 
ATOM   2015 N N   . PHE A 1 228 ? -15.23567 19.20831 16.74405 1.000 33.02985  ? 223 PHE A N   1 
ATOM   2016 C CA  . PHE A 1 228 ? -15.17616 17.74561 16.90991 1.000 30.33061  ? 223 PHE A CA  1 
ATOM   2017 C C   . PHE A 1 228 ? -15.16739 17.37245 18.39258 1.000 33.79170  ? 223 PHE A C   1 
ATOM   2018 O O   . PHE A 1 228 ? -14.18137 16.81907 18.91006 1.000 31.29203  ? 223 PHE A O   1 
ATOM   2019 C CB  . PHE A 1 228 ? -13.93307 17.14698 16.24694 1.000 31.99905  ? 223 PHE A CB  1 
ATOM   2020 C CG  . PHE A 1 228 ? -13.78486 17.47257 14.79718 1.000 29.66201  ? 223 PHE A CG  1 
ATOM   2021 C CD1 . PHE A 1 228 ? -14.75844 17.11615 13.88506 1.000 34.23995  ? 223 PHE A CD1 1 
ATOM   2022 C CD2 . PHE A 1 228 ? -12.63661 18.11570 14.34910 1.000 30.32455  ? 223 PHE A CD2 1 
ATOM   2023 C CE1 . PHE A 1 228 ? -14.62999 17.42747 12.56543 1.000 30.66358  ? 223 PHE A CE1 1 
ATOM   2024 C CE2 . PHE A 1 228 ? -12.49153 18.42993 12.97981 1.000 34.64201  ? 223 PHE A CE2 1 
ATOM   2025 C CZ  . PHE A 1 228 ? -13.49473 18.07169 12.09456 1.000 30.21773  ? 223 PHE A CZ  1 
ATOM   2026 N N   . PRO A 1 229 ? -16.25944 17.65974 19.10546 1.000 35.97335  ? 224 PRO A N   1 
ATOM   2027 C CA  . PRO A 1 229 ? -16.30681 17.36223 20.54862 1.000 32.85925  ? 224 PRO A CA  1 
ATOM   2028 C C   . PRO A 1 229 ? -16.60440 15.88762 20.80865 1.000 40.69155  ? 224 PRO A C   1 
ATOM   2029 O O   . PRO A 1 229 ? -17.64666 15.50344 21.31368 1.000 38.32839  ? 224 PRO A O   1 
ATOM   2030 C CB  . PRO A 1 229 ? -17.43785 18.27906 21.03786 1.000 34.74014  ? 224 PRO A CB  1 
ATOM   2031 C CG  . PRO A 1 229 ? -18.44628 18.26696 19.86518 1.000 40.17834  ? 224 PRO A CG  1 
ATOM   2032 C CD  . PRO A 1 229 ? -17.53843 18.18812 18.58120 1.000 32.75935  ? 224 PRO A CD  1 
ATOM   2033 N N   . GLY A 1 230 ? -15.67164 15.00572 20.45639 1.000 39.17915  ? 225 GLY A N   1 
ATOM   2034 C CA  . GLY A 1 230 ? -15.91237 13.59068 20.63550 1.000 31.86088  ? 225 GLY A CA  1 
ATOM   2035 C C   . GLY A 1 230 ? -15.92192 13.19275 22.10354 1.000 38.37036  ? 225 GLY A C   1 
ATOM   2036 O O   . GLY A 1 230 ? -15.31377 13.83585 22.96572 1.000 34.39185  ? 225 GLY A O   1 
ATOM   2037 N N   . THR A 1 231 ? -16.64931 12.11320 22.39604 1.000 37.34430  ? 226 THR A N   1 
ATOM   2038 C CA  . THR A 1 231 ? -16.73229 11.61701 23.76190 1.000 40.66238  ? 226 THR A CA  1 
ATOM   2039 C C   . THR A 1 231 ? -15.59437 10.67488 24.09198 1.000 38.32423  ? 226 THR A C   1 
ATOM   2040 O O   . THR A 1 231 ? -15.43767 10.28406 25.25533 1.000 42.23283  ? 226 THR A O   1 
ATOM   2041 C CB  . THR A 1 231 ? -18.06306 10.89229 23.99245 1.000 38.49544  ? 226 THR A CB  1 
ATOM   2042 O OG1 . THR A 1 231 ? -18.21143 9.83890  23.03245 1.000 38.86926  ? 226 THR A OG1 1 
ATOM   2043 C CG2 . THR A 1 231 ? -19.26140 11.86867 23.90470 1.000 44.15883  ? 226 THR A CG2 1 
ATOM   2044 N N   . ASP A 1 232 ? -14.82993 10.28157 23.08449 1.000 36.89777  ? 227 ASP A N   1 
ATOM   2045 C CA  . ASP A 1 232 ? -13.67225 9.40582  23.18420 1.000 32.92999  ? 227 ASP A CA  1 
ATOM   2046 C C   . ASP A 1 232 ? -12.99089 9.42064  21.81976 1.000 36.20510  ? 227 ASP A C   1 
ATOM   2047 O O   . ASP A 1 232 ? -13.50404 10.00783 20.86400 1.000 35.55565  ? 227 ASP A O   1 
ATOM   2048 C CB  . ASP A 1 232 ? -14.06732 7.98119  23.61067 1.000 34.98114  ? 227 ASP A CB  1 
ATOM   2049 C CG  . ASP A 1 232 ? -15.09229 7.37994  22.70548 1.000 43.64286  ? 227 ASP A CG  1 
ATOM   2050 O OD1 . ASP A 1 232 ? -14.70761 7.03238  21.57210 1.000 43.56473  ? 227 ASP A OD1 1 
ATOM   2051 O OD2 . ASP A 1 232 ? -16.26349 7.22458  23.13267 1.000 59.02765  ? 227 ASP A OD2 1 
ATOM   2052 N N   . HIS A 1 233 ? -11.82431 8.76980  21.74303 1.000 34.96295  ? 228 HIS A N   1 
ATOM   2053 C CA  . HIS A 1 233 ? -11.02469 8.76331  20.51599 1.000 43.73738  ? 228 HIS A CA  1 
ATOM   2054 C C   . HIS A 1 233 ? -11.83159 8.31930  19.30417 1.000 45.34444  ? 228 HIS A C   1 
ATOM   2055 O O   . HIS A 1 233 ? -11.75713 8.93558  18.22712 1.000 34.65799  ? 228 HIS A O   1 
ATOM   2056 C CB  . HIS A 1 233 ? -9.80705  7.84177  20.68442 1.000 33.89708  ? 228 HIS A CB  1 
ATOM   2057 C CG  . HIS A 1 233 ? -8.78704  8.34918  21.64719 1.000 33.99220  ? 228 HIS A CG  1 
ATOM   2058 N ND1 . HIS A 1 233 ? -9.08148  8.62088  22.96040 1.000 37.47366  ? 228 HIS A ND1 1 
ATOM   2059 C CD2 . HIS A 1 233 ? -7.45671  8.57140  21.50519 1.000 40.15128  ? 228 HIS A CD2 1 
ATOM   2060 C CE1 . HIS A 1 233 ? -7.98498  9.01711  23.58571 1.000 39.47182  ? 228 HIS A CE1 1 
ATOM   2061 N NE2 . HIS A 1 233 ? -6.98512  8.99765  22.72462 1.000 36.84451  ? 228 HIS A NE2 1 
ATOM   2062 N N   . ILE A 1 234 ? -12.57781 7.21867  19.44846 1.000 36.24531  ? 229 ILE A N   1 
ATOM   2063 C CA  . ILE A 1 234 ? -13.29579 6.65603  18.30945 1.000 45.17443  ? 229 ILE A CA  1 
ATOM   2064 C C   . ILE A 1 234 ? -14.52406 7.49389  17.97116 1.000 35.67098  ? 229 ILE A C   1 
ATOM   2065 O O   . ILE A 1 234 ? -14.82037 7.73274  16.80197 1.000 36.39946  ? 229 ILE A O   1 
ATOM   2066 C CB  . ILE A 1 234 ? -13.67385 5.19064  18.59070 1.000 49.96136  ? 229 ILE A CB  1 
ATOM   2067 C CG1 . ILE A 1 234 ? -12.39970 4.33083  18.68153 1.000 46.86738  ? 229 ILE A CG1 1 
ATOM   2068 C CG2 . ILE A 1 234 ? -14.61618 4.66089  17.49448 1.000 41.25751  ? 229 ILE A CG2 1 
ATOM   2069 C CD1 . ILE A 1 234 ? -11.43825 4.46076  17.43673 1.000 48.23801  ? 229 ILE A CD1 1 
ATOM   2070 N N   . ASP A 1 235 ? -15.30038 7.91774  18.96536 1.000 33.22769  ? 230 ASP A N   1 
ATOM   2071 C CA  . ASP A 1 235 ? -16.36771 8.86394  18.66452 1.000 35.43968  ? 230 ASP A CA  1 
ATOM   2072 C C   . ASP A 1 235 ? -15.82568 10.07199 17.89208 1.000 37.69776  ? 230 ASP A C   1 
ATOM   2073 O O   . ASP A 1 235 ? -16.41944 10.51422 16.89577 1.000 33.87432  ? 230 ASP A O   1 
ATOM   2074 C CB  . ASP A 1 235 ? -17.06829 9.28879  19.96835 1.000 41.41597  ? 230 ASP A CB  1 
ATOM   2075 C CG  . ASP A 1 235 ? -18.22873 10.24699 19.72178 1.000 45.76445  ? 230 ASP A CG  1 
ATOM   2076 O OD1 . ASP A 1 235 ? -19.17286 9.75474  19.09736 1.000 48.68207  ? 230 ASP A OD1 1 
ATOM   2077 O OD2 . ASP A 1 235 ? -18.26248 11.43576 20.18650 1.000 40.35732  ? 230 ASP A OD2 1 
ATOM   2078 N N   . GLN A 1 236 ? -14.67584 10.59681 18.31541 1.000 34.48044  ? 231 GLN A N   1 
ATOM   2079 C CA  . GLN A 1 236 ? -14.16517 11.80592 17.67924 1.000 29.91995  ? 231 GLN A CA  1 
ATOM   2080 C C   . GLN A 1 236 ? -13.76206 11.50511 16.24602 1.000 39.86464  ? 231 GLN A C   1 
ATOM   2081 O O   . GLN A 1 236 ? -13.95995 12.33376 15.34918 1.000 30.73132  ? 231 GLN A O   1 
ATOM   2082 C CB  . GLN A 1 236 ? -13.00610 12.36999 18.48612 1.000 29.31733  ? 231 GLN A CB  1 
ATOM   2083 C CG  . GLN A 1 236 ? -12.37958 13.63122 17.89427 1.000 35.43405  ? 231 GLN A CG  1 
ATOM   2084 C CD  . GLN A 1 236 ? -11.46473 14.33956 18.86101 1.000 34.83297  ? 231 GLN A CD  1 
ATOM   2085 O OE1 . GLN A 1 236 ? -11.55136 14.12874 20.07256 1.000 37.98939  ? 231 GLN A OE1 1 
ATOM   2086 N NE2 . GLN A 1 236 ? -10.48582 15.07830 18.32504 1.000 37.86403  ? 231 GLN A NE2 1 
ATOM   2087 N N   . LEU A 1 237 ? -13.19589 10.31997 16.00912 1.000 31.60359  ? 232 LEU A N   1 
ATOM   2088 C CA  . LEU A 1 237 ? -12.83905 9.96282  14.64522 1.000 39.29622  ? 232 LEU A CA  1 
ATOM   2089 C C   . LEU A 1 237 ? -14.07568 9.92013  13.76105 1.000 36.92004  ? 232 LEU A C   1 
ATOM   2090 O O   . LEU A 1 237 ? -14.04675 10.41905 12.63938 1.000 33.74018  ? 232 LEU A O   1 
ATOM   2091 C CB  . LEU A 1 237 ? -12.10276 8.62015  14.62052 1.000 36.69519  ? 232 LEU A CB  1 
ATOM   2092 C CG  . LEU A 1 237 ? -11.71035 8.11061  13.21435 1.000 46.36478  ? 232 LEU A CG  1 
ATOM   2093 C CD1 . LEU A 1 237 ? -10.79727 9.13502  12.45111 1.000 33.96048  ? 232 LEU A CD1 1 
ATOM   2094 C CD2 . LEU A 1 237 ? -11.11903 6.71532  13.21833 1.000 36.22842  ? 232 LEU A CD2 1 
ATOM   2095 N N   . LYS A 1 238 ? -15.18796 9.35886  14.25259 1.000 31.87291  ? 233 LYS A N   1 
ATOM   2096 C CA  . LYS A 1 238 ? -16.39018 9.30331  13.42584 1.000 36.58310  ? 233 LYS A CA  1 
ATOM   2097 C C   . LYS A 1 238 ? -16.90541 10.69960 13.10619 1.000 42.47038  ? 233 LYS A C   1 
ATOM   2098 O O   . LYS A 1 238 ? -17.33910 10.96264 11.97438 1.000 31.47870  ? 233 LYS A O   1 
ATOM   2099 C CB  . LYS A 1 238 ? -17.46205 8.45039  14.11625 1.000 41.63906  ? 233 LYS A CB  1 
ATOM   2100 C CG  . LYS A 1 238 ? -17.08406 6.97965  14.24943 1.000 39.63596  ? 233 LYS A CG  1 
ATOM   2101 C CD  . LYS A 1 238 ? -18.09846 6.20815  15.04881 1.000 52.64324  ? 233 LYS A CD  1 
ATOM   2102 C CE  . LYS A 1 238 ? -17.60804 4.81684  15.46480 1.000 48.25689  ? 233 LYS A CE  1 
ATOM   2103 N NZ  . LYS A 1 238 ? -18.70698 4.13547  16.20630 1.000 46.01211  ? 233 LYS A NZ  1 
ATOM   2104 N N   . LEU A 1 239 ? -16.86885 11.61039 14.09219 1.000 33.03896  ? 234 LEU A N   1 
ATOM   2105 C CA  . LEU A 1 239 ? -17.21810 13.00502 13.83413 1.000 36.53555  ? 234 LEU A CA  1 
ATOM   2106 C C   . LEU A 1 239 ? -16.31701 13.61783 12.78143 1.000 32.09050  ? 234 LEU A C   1 
ATOM   2107 O O   . LEU A 1 239 ? -16.79137 14.39165 11.94511 1.000 30.98873  ? 234 LEU A O   1 
ATOM   2108 C CB  . LEU A 1 239 ? -17.12065 13.84386 15.11209 1.000 32.04325  ? 234 LEU A CB  1 
ATOM   2109 C CG  . LEU A 1 239 ? -18.05633 13.47877 16.26059 1.000 37.59068  ? 234 LEU A CG  1 
ATOM   2110 C CD1 . LEU A 1 239 ? -17.77571 14.33262 17.47731 1.000 38.28743  ? 234 LEU A CD1 1 
ATOM   2111 C CD2 . LEU A 1 239 ? -19.51116 13.66198 15.79311 1.000 46.95934  ? 234 LEU A CD2 1 
ATOM   2112 N N   . ILE A 1 240 ? -15.00952 13.32145 12.82766 1.000 27.70888  ? 235 ILE A N   1 
ATOM   2113 C CA  . ILE A 1 240 ? -14.10443 13.85432 11.83092 1.000 27.95429  ? 235 ILE A CA  1 
ATOM   2114 C C   . ILE A 1 240 ? -14.42954 13.28257 10.45710 1.000 31.78759  ? 235 ILE A C   1 
ATOM   2115 O O   . ILE A 1 240 ? -14.51773 14.01321 9.46517  1.000 30.59609  ? 235 ILE A O   1 
ATOM   2116 C CB  . ILE A 1 240 ? -12.63755 13.56312 12.21193 1.000 31.17930  ? 235 ILE A CB  1 
ATOM   2117 C CG1 . ILE A 1 240 ? -12.16923 14.46867 13.37314 1.000 31.53769  ? 235 ILE A CG1 1 
ATOM   2118 C CG2 . ILE A 1 240 ? -11.76176 13.77201 11.03923 1.000 27.12563  ? 235 ILE A CG2 1 
ATOM   2119 C CD1 . ILE A 1 240 ? -11.02304 13.83884 14.23538 1.000 34.95798  ? 235 ILE A CD1 1 
ATOM   2120 N N   . LEU A 1 241 ? -14.57538 11.96209 10.37777 1.000 28.66281  ? 236 LEU A N   1 
ATOM   2121 C CA  . LEU A 1 241 ? -14.76603 11.32779 9.07883  1.000 38.98598  ? 236 LEU A CA  1 
ATOM   2122 C C   . LEU A 1 241 ? -16.09483 11.71646 8.47761  1.000 36.78759  ? 236 LEU A C   1 
ATOM   2123 O O   . LEU A 1 241 ? -16.23284 11.75413 7.25222  1.000 42.96704  ? 236 LEU A O   1 
ATOM   2124 C CB  . LEU A 1 241 ? -14.67908 9.80806  9.20041  1.000 36.23693  ? 236 LEU A CB  1 
ATOM   2125 C CG  . LEU A 1 241 ? -13.31212 9.34768  9.75831  1.000 30.67181  ? 236 LEU A CG  1 
ATOM   2126 C CD1 . LEU A 1 241 ? -13.21533 7.77964  9.81940  1.000 30.31449  ? 236 LEU A CD1 1 
ATOM   2127 C CD2 . LEU A 1 241 ? -12.08824 9.96125  8.95316  1.000 39.34645  ? 236 LEU A CD2 1 
ATOM   2128 N N   . ARG A 1 242 ? -17.08780 11.99701 9.30919  1.000 32.02425  ? 237 ARG A N   1 
ATOM   2129 C CA  . ARG A 1 242 ? -18.35972 12.38283 8.72615  1.000 36.34843  ? 237 ARG A CA  1 
ATOM   2130 C C   . ARG A 1 242 ? -18.24091 13.73352 8.04195  1.000 44.78500  ? 237 ARG A C   1 
ATOM   2131 O O   . ARG A 1 242 ? -18.88593 13.95724 7.01863  1.000 35.84931  ? 237 ARG A O   1 
ATOM   2132 C CB  . ARG A 1 242 ? -19.48838 12.38935 9.75855  1.000 42.73624  ? 237 ARG A CB  1 
ATOM   2133 C CG  . ARG A 1 242 ? -20.82800 12.81215 9.11865  1.000 44.84702  ? 237 ARG A CG  1 
ATOM   2134 C CD  . ARG A 1 242 ? -22.02279 12.75137 10.07493 1.000 77.93419  ? 237 ARG A CD  1 
ATOM   2135 N NE  . ARG A 1 242 ? -21.70687 13.16783 11.42836 1.000 70.36402  ? 237 ARG A NE  1 
ATOM   2136 C CZ  . ARG A 1 242 ? -21.82313 14.41654 11.86187 1.000 83.94135  ? 237 ARG A CZ  1 
ATOM   2137 N NH1 . ARG A 1 242 ? -22.32642 15.37719 11.09397 1.000 76.98936  ? 237 ARG A NH1 1 
ATOM   2138 N NH2 . ARG A 1 242 ? -21.45372 14.70550 13.10561 1.000 64.06192  ? 237 ARG A NH2 1 
ATOM   2139 N N   . LEU A 1 243 ? -17.39840 14.62662 8.55332  1.000 34.44958  ? 238 LEU A N   1 
ATOM   2140 C CA  . LEU A 1 243 ? -17.21863 15.91282 7.88584  1.000 34.39367  ? 238 LEU A CA  1 
ATOM   2141 C C   . LEU A 1 243 ? -16.27908 15.80780 6.69246  1.000 37.03549  ? 238 LEU A C   1 
ATOM   2142 O O   . LEU A 1 243 ? -16.58274 16.31073 5.60227  1.000 34.40625  ? 238 LEU A O   1 
ATOM   2143 C CB  . LEU A 1 243 ? -16.68609 16.94891 8.86416  1.000 33.07827  ? 238 LEU A CB  1 
ATOM   2144 C CG  . LEU A 1 243 ? -16.43910 18.35290 8.29811  1.000 38.05332  ? 238 LEU A CG  1 
ATOM   2145 C CD1 . LEU A 1 243 ? -17.76261 19.12662 8.12231  1.000 39.70837  ? 238 LEU A CD1 1 
ATOM   2146 C CD2 . LEU A 1 243 ? -15.45042 19.17140 9.12911  1.000 36.25931  ? 238 LEU A CD2 1 
ATOM   2147 N N   . VAL A 1 244 ? -15.10407 15.20500 6.87890  1.000 35.70596  ? 239 VAL A N   1 
ATOM   2148 C CA  . VAL A 1 244 ? -14.09342 15.28578 5.82871  1.000 32.70340  ? 239 VAL A CA  1 
ATOM   2149 C C   . VAL A 1 244 ? -14.08860 14.05908 4.93008  1.000 36.57475  ? 239 VAL A C   1 
ATOM   2150 O O   . VAL A 1 244 ? -13.35306 14.02968 3.92410  1.000 46.35882  ? 239 VAL A O   1 
ATOM   2151 C CB  . VAL A 1 244 ? -12.68737 15.52298 6.41109  1.000 33.57710  ? 239 VAL A CB  1 
ATOM   2152 C CG1 . VAL A 1 244 ? -12.72230 16.73913 7.37616  1.000 29.56826  ? 239 VAL A CG1 1 
ATOM   2153 C CG2 . VAL A 1 244 ? -12.16867 14.24344 7.06088  1.000 36.27005  ? 239 VAL A CG2 1 
ATOM   2154 N N   . GLY A 1 245 ? -14.89830 13.06158 5.23814  1.000 31.21882  ? 240 GLY A N   1 
ATOM   2155 C CA  . GLY A 1 245 ? -14.96304 11.88357 4.39467  1.000 40.19198  ? 240 GLY A CA  1 
ATOM   2156 C C   . GLY A 1 245 ? -14.00398 10.82578 4.89051  1.000 42.63039  ? 240 GLY A C   1 
ATOM   2157 O O   . GLY A 1 245 ? -13.02456 11.11544 5.55883  1.000 34.53743  ? 240 GLY A O   1 
ATOM   2158 N N   . THR A 1 246 ? -14.30582 9.56846  4.57129  1.000 36.68477  ? 241 THR A N   1 
ATOM   2159 C CA  . THR A 1 246 ? -13.40684 8.47422  4.93308  1.000 36.85536  ? 241 THR A CA  1 
ATOM   2160 C C   . THR A 1 246 ? -12.16630 8.47435  4.04216  1.000 42.63459  ? 241 THR A C   1 
ATOM   2161 O O   . THR A 1 246 ? -12.18384 9.01053  2.94337  1.000 43.08593  ? 241 THR A O   1 
ATOM   2162 C CB  . THR A 1 246 ? -14.14240 7.13756  4.82498  1.000 38.72906  ? 241 THR A CB  1 
ATOM   2163 O OG1 . THR A 1 246 ? -14.93647 7.11989  3.63187  1.000 37.26998  ? 241 THR A OG1 1 
ATOM   2164 C CG2 . THR A 1 246 ? -15.10747 6.97741  6.01762  1.000 36.50169  ? 241 THR A CG2 1 
ATOM   2165 N N   . PRO A 1 247 ? -11.07001 7.87511  4.50334  1.000 42.48296  ? 242 PRO A N   1 
ATOM   2166 C CA  . PRO A 1 247 ? -9.82257  7.91265  3.74090  1.000 42.62992  ? 242 PRO A CA  1 
ATOM   2167 C C   . PRO A 1 247 ? -9.93580  7.10351  2.46423  1.000 56.05112  ? 242 PRO A C   1 
ATOM   2168 O O   . PRO A 1 247 ? -10.61634 6.07777  2.41812  1.000 44.19267  ? 242 PRO A O   1 
ATOM   2169 C CB  . PRO A 1 247 ? -8.80506  7.26133  4.68568  1.000 42.86422  ? 242 PRO A CB  1 
ATOM   2170 C CG  . PRO A 1 247 ? -9.52534  6.94751  5.93046  1.000 51.48010  ? 242 PRO A CG  1 
ATOM   2171 C CD  . PRO A 1 247 ? -10.98119 6.93540  5.62026  1.000 47.64673  ? 242 PRO A CD  1 
ATOM   2172 N N   . GLY A 1 248 ? -9.25336  7.58979  1.42033  1.000 50.58170  ? 243 GLY A N   1 
ATOM   2173 C CA  . GLY A 1 248 ? -9.04175  6.82184  0.21173  1.000 59.08577  ? 243 GLY A CA  1 
ATOM   2174 C C   . GLY A 1 248 ? -7.79226  5.95804  0.30255  1.000 56.66024  ? 243 GLY A C   1 
ATOM   2175 O O   . GLY A 1 248 ? -7.03420  5.99776  1.26862  1.000 41.60352  ? 243 GLY A O   1 
ATOM   2176 N N   . ALA A 1 249 ? -7.59459  5.13192  -0.72400 1.000 55.37185  ? 244 ALA A N   1 
ATOM   2177 C CA  . ALA A 1 249 ? -6.52022  4.15107  -0.65365 1.000 39.23311  ? 244 ALA A CA  1 
ATOM   2178 C C   . ALA A 1 249 ? -5.15478  4.82393  -0.59081 1.000 49.72838  ? 244 ALA A C   1 
ATOM   2179 O O   . ALA A 1 249 ? -4.21778  4.27488  -0.00108 1.000 54.84250  ? 244 ALA A O   1 
ATOM   2180 C CB  . ALA A 1 249 ? -6.60365  3.19401  -1.83784 1.000 59.38156  ? 244 ALA A CB  1 
ATOM   2181 N N   . GLU A 1 250 ? -5.02983  6.02200  -1.15555 1.000 44.57404  ? 245 GLU A N   1 
ATOM   2182 C CA  . GLU A 1 250 ? -3.75035  6.70831  -1.11271 1.000 46.28146  ? 245 GLU A CA  1 
ATOM   2183 C C   . GLU A 1 250 ? -3.37632  7.08515  0.31478  1.000 52.79560  ? 245 GLU A C   1 
ATOM   2184 O O   . GLU A 1 250 ? -2.22781  6.89144  0.73557  1.000 42.71391  ? 245 GLU A O   1 
ATOM   2185 C CB  . GLU A 1 250 ? -3.79360  7.93808  -2.01002 1.000 59.90599  ? 245 GLU A CB  1 
ATOM   2186 C CG  . GLU A 1 250 ? -2.42828  8.57677  -2.22274 1.000 62.03565  ? 245 GLU A CG  1 
ATOM   2187 C CD  . GLU A 1 250 ? -2.52707  9.97746  -2.83619 1.000 88.70443  ? 245 GLU A CD  1 
ATOM   2188 O OE1 . GLU A 1 250 ? -1.59063  10.79196 -2.62965 1.000 91.00534  ? 245 GLU A OE1 1 
ATOM   2189 O OE2 . GLU A 1 250 ? -3.54264  10.26805 -3.51609 1.000 89.61771  ? 245 GLU A OE2 1 
ATOM   2190 N N   . LEU A 1 251 ? -4.32521  7.60822  1.09225  1.000 39.79538  ? 246 LEU A N   1 
ATOM   2191 C CA  . LEU A 1 251 ? -3.97089  7.92646  2.47252  1.000 44.34258  ? 246 LEU A CA  1 
ATOM   2192 C C   . LEU A 1 251 ? -3.84001  6.64758  3.29674  1.000 45.94449  ? 246 LEU A C   1 
ATOM   2193 O O   . LEU A 1 251 ? -3.00314  6.56655  4.20689  1.000 45.93029  ? 246 LEU A O   1 
ATOM   2194 C CB  . LEU A 1 251 ? -5.01662  8.83934  3.09974  1.000 46.43715  ? 246 LEU A CB  1 
ATOM   2195 C CG  . LEU A 1 251 ? -5.01195  8.93617  4.62334  1.000 50.24549  ? 246 LEU A CG  1 
ATOM   2196 C CD1 . LEU A 1 251 ? -3.60158  9.36241  5.13129  1.000 42.04662  ? 246 LEU A CD1 1 
ATOM   2197 C CD2 . LEU A 1 251 ? -6.02641  9.97187  5.05226  1.000 42.54124  ? 246 LEU A CD2 1 
ATOM   2198 N N   . LEU A 1 252 ? -4.63127  5.62450  2.97134  1.000 38.53250  ? 247 LEU A N   1 
ATOM   2199 C CA  . LEU A 1 252 ? -4.52163  4.36210  3.69541  1.000 53.08633  ? 247 LEU A CA  1 
ATOM   2200 C C   . LEU A 1 252 ? -3.12204  3.76678  3.58314  1.000 44.52230  ? 247 LEU A C   1 
ATOM   2201 O O   . LEU A 1 252 ? -2.60604  3.20566  4.55501  1.000 51.13838  ? 247 LEU A O   1 
ATOM   2202 C CB  . LEU A 1 252 ? -5.55674  3.37031  3.17974  1.000 59.07131  ? 247 LEU A CB  1 
ATOM   2203 C CG  . LEU A 1 252 ? -6.91368  3.45493  3.86750  1.000 60.33377  ? 247 LEU A CG  1 
ATOM   2204 C CD1 . LEU A 1 252 ? -7.97868  2.76374  3.00579  1.000 61.53884  ? 247 LEU A CD1 1 
ATOM   2205 C CD2 . LEU A 1 252 ? -6.79138  2.79385  5.23095  1.000 63.56096  ? 247 LEU A CD2 1 
ATOM   2206 N N   . LYS A 1 253 ? -2.49537  3.86569  2.40768  1.000 45.03419  ? 248 LYS A N   1 
ATOM   2207 C CA  . LYS A 1 253 ? -1.14412  3.32613  2.26515  1.000 44.02545  ? 248 LYS A CA  1 
ATOM   2208 C C   . LYS A 1 253 ? -0.17794  3.94016  3.26161  1.000 53.79244  ? 248 LYS A C   1 
ATOM   2209 O O   . LYS A 1 253 ? 0.79582   3.29538  3.65067  1.000 55.15241  ? 248 LYS A O   1 
ATOM   2210 C CB  . LYS A 1 253 ? -0.58585  3.54163  0.85046  1.000 54.25658  ? 248 LYS A CB  1 
ATOM   2211 C CG  . LYS A 1 253 ? -0.54926  2.28804  -0.03098 1.000 66.91040  ? 248 LYS A CG  1 
ATOM   2212 C CD  . LYS A 1 253 ? -0.87256  2.59045  -1.49949 1.000 89.95787  ? 248 LYS A CD  1 
ATOM   2213 C CE  . LYS A 1 253 ? 0.13933   3.57358  -2.09373 1.000 85.14695  ? 248 LYS A CE  1 
ATOM   2214 N NZ  . LYS A 1 253 ? -0.38354  4.33537  -3.26228 1.000 83.56375  ? 248 LYS A NZ  1 
ATOM   2215 N N   . LYS A 1 254 ? -0.39565  5.19075  3.64419  1.000 48.11032  ? 249 LYS A N   1 
ATOM   2216 C CA  . LYS A 1 254 ? 0.54024   5.88952  4.50278  1.000 48.14579  ? 249 LYS A CA  1 
ATOM   2217 C C   . LYS A 1 254 ? 0.32582   5.59098  5.97820  1.000 61.53264  ? 249 LYS A C   1 
ATOM   2218 O O   . LYS A 1 254 ? 1.16914   5.98417  6.78848  1.000 54.80905  ? 249 LYS A O   1 
ATOM   2219 C CB  . LYS A 1 254 ? 0.42912   7.39547  4.27276  1.000 55.15590  ? 249 LYS A CB  1 
ATOM   2220 C CG  . LYS A 1 254 ? 0.37522   7.80039  2.82217  1.000 54.25512  ? 249 LYS A CG  1 
ATOM   2221 C CD  . LYS A 1 254 ? 0.35445   9.31494  2.68977  1.000 53.80739  ? 249 LYS A CD  1 
ATOM   2222 C CE  . LYS A 1 254 ? 0.10584   9.76203  1.24201  1.000 45.30226  ? 249 LYS A CE  1 
ATOM   2223 N NZ  . LYS A 1 254 ? 0.10634   11.24180 1.11140  1.000 41.03436  ? 249 LYS A NZ  1 
ATOM   2224 N N   . ILE A 1 255 ? -0.76483  4.91761  6.34982  1.000 46.23656  ? 250 ILE A N   1 
ATOM   2225 C CA  . ILE A 1 255 ? -0.98779  4.54067  7.74418  1.000 66.06305  ? 250 ILE A CA  1 
ATOM   2226 C C   . ILE A 1 255 ? -0.13231  3.31750  8.07987  1.000 71.04141  ? 250 ILE A C   1 
ATOM   2227 O O   . ILE A 1 255 ? -0.34219  2.22992  7.53249  1.000 60.53776  ? 250 ILE A O   1 
ATOM   2228 C CB  . ILE A 1 255 ? -2.47614  4.27795  8.00664  1.000 51.60916  ? 250 ILE A CB  1 
ATOM   2229 C CG1 . ILE A 1 255 ? -3.27199  5.56525  7.76656  1.000 53.94454  ? 250 ILE A CG1 1 
ATOM   2230 C CG2 . ILE A 1 255 ? -2.68148  3.72640  9.38753  1.000 46.60772  ? 250 ILE A CG2 1 
ATOM   2231 C CD1 . ILE A 1 255 ? -4.77522  5.42518  7.98237  1.000 42.61192  ? 250 ILE A CD1 1 
ATOM   2232 N N   . SER A 1 256 ? 0.80823   3.48857  9.01828  1.000 67.67711  ? 251 SER A N   1 
ATOM   2233 C CA  . SER A 1 256 ? 1.88004   2.51176  9.21175  1.000 75.94146  ? 251 SER A CA  1 
ATOM   2234 C C   . SER A 1 256 ? 1.37729   1.22817  9.86904  1.000 74.45774  ? 251 SER A C   1 
ATOM   2235 O O   . SER A 1 256 ? 1.87681   0.13343  9.57380  1.000 77.73130  ? 251 SER A O   1 
ATOM   2236 C CB  . SER A 1 256 ? 2.99888   3.13235  10.05352 1.000 77.02084  ? 251 SER A CB  1 
ATOM   2237 O OG  . SER A 1 256 ? 3.60749   2.13598  10.85898 1.000 85.57727  ? 251 SER A OG  1 
ATOM   2238 N N   . SER A 1 257 ? 0.41572   1.33890  10.78084 1.000 66.22137  ? 252 SER A N   1 
ATOM   2239 C CA  . SER A 1 257 ? -0.02971  0.19650  11.57263 1.000 73.94288  ? 252 SER A CA  1 
ATOM   2240 C C   . SER A 1 257 ? -1.10206  -0.58727 10.82429 1.000 76.99685  ? 252 SER A C   1 
ATOM   2241 O O   . SER A 1 257 ? -2.18469  -0.05562 10.54579 1.000 77.03285  ? 252 SER A O   1 
ATOM   2242 C CB  . SER A 1 257 ? -0.56238  0.65333  12.93286 1.000 80.96283  ? 252 SER A CB  1 
ATOM   2243 O OG  . SER A 1 257 ? -0.86004  2.03928  12.92361 1.000 77.67490  ? 252 SER A OG  1 
ATOM   2244 N N   . GLU A 1 258 ? -0.80755  -1.85593 10.51422 1.000 70.34252  ? 253 GLU A N   1 
ATOM   2245 C CA  . GLU A 1 258 ? -1.80268  -2.70604 9.87084  1.000 73.56815  ? 253 GLU A CA  1 
ATOM   2246 C C   . GLU A 1 258 ? -3.13014  -2.66537 10.60934 1.000 71.12746  ? 253 GLU A C   1 
ATOM   2247 O O   . GLU A 1 258 ? -4.19165  -2.85251 9.99909  1.000 75.53356  ? 253 GLU A O   1 
ATOM   2248 C CB  . GLU A 1 258 ? -1.30363  -4.15511 9.78326  1.000 75.87972  ? 253 GLU A CB  1 
ATOM   2249 C CG  . GLU A 1 258 ? -2.28115  -5.08907 9.04226  1.000 94.88472  ? 253 GLU A CG  1 
ATOM   2250 C CD  . GLU A 1 258 ? -1.94982  -6.57742 9.19115  1.000 99.05174  ? 253 GLU A CD  1 
ATOM   2251 O OE1 . GLU A 1 258 ? -1.11367  -6.93381 10.05041 1.000 94.34627  ? 253 GLU A OE1 1 
ATOM   2252 O OE2 . GLU A 1 258 ? -2.55256  -7.39598 8.46124  1.000 97.90545  ? 253 GLU A OE2 1 
ATOM   2253 N N   . SER A 1 259 ? -3.09530  -2.43016 11.92185 1.000 69.36041  ? 254 SER A N   1 
ATOM   2254 C CA  . SER A 1 259 ? -4.31634  -2.52123 12.71492 1.000 71.25841  ? 254 SER A CA  1 
ATOM   2255 C C   . SER A 1 259 ? -5.18155  -1.28207 12.54495 1.000 52.18280  ? 254 SER A C   1 
ATOM   2256 O O   . SER A 1 259 ? -6.40174  -1.40007 12.40147 1.000 58.36071  ? 254 SER A O   1 
ATOM   2257 C CB  . SER A 1 259 ? -3.97745  -2.75287 14.19368 1.000 65.12557  ? 254 SER A CB  1 
ATOM   2258 O OG  . SER A 1 259 ? -3.03138  -1.80140 14.64287 1.000 74.32217  ? 254 SER A OG  1 
ATOM   2259 N N   . ALA A 1 260 ? -4.57371  -0.09151 12.55405 1.000 62.74980  ? 255 ALA A N   1 
ATOM   2260 C CA  . ALA A 1 260 ? -5.33394  1.12619  12.27678 1.000 57.38541  ? 255 ALA A CA  1 
ATOM   2261 C C   . ALA A 1 260 ? -5.97389  1.07511  10.89256 1.000 57.86262  ? 255 ALA A C   1 
ATOM   2262 O O   . ALA A 1 260 ? -7.15872  1.39714  10.72772 1.000 56.60086  ? 255 ALA A O   1 
ATOM   2263 C CB  . ALA A 1 260 ? -4.43035  2.34653  12.41511 1.000 50.75367  ? 255 ALA A CB  1 
ATOM   2264 N N   . ARG A 1 261 ? -5.20458  0.67408  9.87609  1.000 59.90867  ? 256 ARG A N   1 
ATOM   2265 C CA  . ARG A 1 261 ? -5.78351  0.51322  8.54408  1.000 58.09244  ? 256 ARG A CA  1 
ATOM   2266 C C   . ARG A 1 261 ? -6.94139  -0.46745 8.58248  1.000 58.19773  ? 256 ARG A C   1 
ATOM   2267 O O   . ARG A 1 261 ? -8.00614  -0.23005 8.00067  1.000 57.00758  ? 256 ARG A O   1 
ATOM   2268 C CB  . ARG A 1 261 ? -4.72394  0.01714  7.56007  1.000 65.68945  ? 256 ARG A CB  1 
ATOM   2269 C CG  . ARG A 1 261 ? -4.06212  1.08327  6.73188  1.000 61.84024  ? 256 ARG A CG  1 
ATOM   2270 C CD  . ARG A 1 261 ? -3.12404  0.48385  5.68777  1.000 57.83415  ? 256 ARG A CD  1 
ATOM   2271 N NE  . ARG A 1 261 ? -2.61748  -0.83002 6.05661  1.000 59.99137  ? 256 ARG A NE  1 
ATOM   2272 C CZ  . ARG A 1 261 ? -1.36141  -1.07847 6.39949  1.000 81.37001  ? 256 ARG A CZ  1 
ATOM   2273 N NH1 . ARG A 1 261 ? -0.44272  -0.12355 6.40207  1.000 81.39566  ? 256 ARG A NH1 1 
ATOM   2274 N NH2 . ARG A 1 261 ? -1.01557  -2.31760 6.74128  1.000 80.28718  ? 256 ARG A NH2 1 
ATOM   2275 N N   . ASN A 1 262 ? -6.74218  -1.58906 9.26890  1.000 53.99484  ? 257 ASN A N   1 
ATOM   2276 C CA  . ASN A 1 262 ? -7.77687  -2.60887 9.33362  1.000 52.76762  ? 257 ASN A CA  1 
ATOM   2277 C C   . ASN A 1 262 ? -9.04899  -2.05403 9.96459  1.000 55.26091  ? 257 ASN A C   1 
ATOM   2278 O O   . ASN A 1 262 ? -10.15838 -2.32690 9.49433  1.000 53.74408  ? 257 ASN A O   1 
ATOM   2279 C CB  . ASN A 1 262 ? -7.23501  -3.80106 10.11774 1.000 71.23481  ? 257 ASN A CB  1 
ATOM   2280 C CG  . ASN A 1 262 ? -7.41838  -5.09513 9.39399  1.000 63.15735  ? 257 ASN A CG  1 
ATOM   2281 O OD1 . ASN A 1 262 ? -8.13514  -5.16660 8.40024  1.000 75.06689  ? 257 ASN A OD1 1 
ATOM   2282 N ND2 . ASN A 1 262 ? -6.71568  -6.12364 9.84713  1.000 79.39346  ? 257 ASN A ND2 1 
ATOM   2283 N N   . TYR A 1 263 ? -8.91313  -1.26270 11.02905 1.000 52.31663  ? 258 TYR A N   1 
ATOM   2284 C CA  . TYR A 1 263 ? -10.09752 -0.65855 11.62573 1.000 50.17786  ? 258 TYR A CA  1 
ATOM   2285 C C   . TYR A 1 263 ? -10.70717 0.38126  10.69418 1.000 42.19821  ? 258 TYR A C   1 
ATOM   2286 O O   . TYR A 1 263 ? -11.92529 0.39128  10.46417 1.000 49.56156  ? 258 TYR A O   1 
ATOM   2287 C CB  . TYR A 1 263 ? -9.75399  -0.02355 12.97364 1.000 47.63111  ? 258 TYR A CB  1 
ATOM   2288 C CG  . TYR A 1 263 ? -10.93523 0.73033  13.50325 1.000 46.57268  ? 258 TYR A CG  1 
ATOM   2289 C CD1 . TYR A 1 263 ? -12.07555 0.05491  13.89231 1.000 44.25352  ? 258 TYR A CD1 1 
ATOM   2290 C CD2 . TYR A 1 263 ? -10.94515 2.12113  13.55605 1.000 55.10376  ? 258 TYR A CD2 1 
ATOM   2291 C CE1 . TYR A 1 263 ? -13.19683 0.72796  14.33556 1.000 48.42306  ? 258 TYR A CE1 1 
ATOM   2292 C CE2 . TYR A 1 263 ? -12.07101 2.81455  14.01857 1.000 51.28362  ? 258 TYR A CE2 1 
ATOM   2293 C CZ  . TYR A 1 263 ? -13.18662 2.10489  14.40437 1.000 53.08611  ? 258 TYR A CZ  1 
ATOM   2294 O OH  . TYR A 1 263 ? -14.29934 2.76407  14.85267 1.000 50.85974  ? 258 TYR A OH  1 
ATOM   2295 N N   . ILE A 1 264 ? -9.87185  1.28312  10.17677 1.000 55.34194  ? 259 ILE A N   1 
ATOM   2296 C CA  . ILE A 1 264 ? -10.33045 2.27379  9.20355  1.000 58.05195  ? 259 ILE A CA  1 
ATOM   2297 C C   . ILE A 1 264 ? -11.22284 1.62338  8.15840  1.000 45.63356  ? 259 ILE A C   1 
ATOM   2298 O O   . ILE A 1 264 ? -12.31165 2.11715  7.83831  1.000 49.63418  ? 259 ILE A O   1 
ATOM   2299 C CB  . ILE A 1 264 ? -9.12930  2.96373  8.53909  1.000 55.82644  ? 259 ILE A CB  1 
ATOM   2300 C CG1 . ILE A 1 264 ? -8.62671  4.08939  9.41035  1.000 55.65145  ? 259 ILE A CG1 1 
ATOM   2301 C CG2 . ILE A 1 264 ? -9.55000  3.54383  7.18924  1.000 67.47092  ? 259 ILE A CG2 1 
ATOM   2302 C CD1 . ILE A 1 264 ? -9.52192  5.30420  9.31041  1.000 63.31958  ? 259 ILE A CD1 1 
ATOM   2303 N N   . GLN A 1 265 ? -10.75032 0.52855  7.58099  1.000 53.25994  ? 260 GLN A N   1 
ATOM   2304 C CA  . GLN A 1 265 ? -11.45917 -0.10373 6.48205  1.000 57.21240  ? 260 GLN A CA  1 
ATOM   2305 C C   . GLN A 1 265 ? -12.72287 -0.79767 6.93595  1.000 57.32386  ? 260 GLN A C   1 
ATOM   2306 O O   . GLN A 1 265 ? -13.53138 -1.18552 6.08670  1.000 61.58283  ? 260 GLN A O   1 
ATOM   2307 C CB  . GLN A 1 265 ? -10.51789 -1.08317 5.78468  1.000 66.70131  ? 260 GLN A CB  1 
ATOM   2308 C CG  . GLN A 1 265 ? -9.44498  -0.35591 4.99203  1.000 62.13465  ? 260 GLN A CG  1 
ATOM   2309 C CD  . GLN A 1 265 ? -8.66543  -1.26551 4.06572  1.000 78.12462  ? 260 GLN A CD  1 
ATOM   2310 O OE1 . GLN A 1 265 ? -7.66934  -1.87559 4.46598  1.000 77.58868  ? 260 GLN A OE1 1 
ATOM   2311 N NE2 . GLN A 1 265 ? -9.10456  -1.34698 2.81075  1.000 85.23425  ? 260 GLN A NE2 1 
ATOM   2312 N N   . SER A 1 266 ? -12.92644 -0.94929 8.24871  1.000 54.06128  ? 261 SER A N   1 
ATOM   2313 C CA  . SER A 1 266 ? -14.18554 -1.51606 8.70930  1.000 56.93561  ? 261 SER A CA  1 
ATOM   2314 C C   . SER A 1 266 ? -15.33897 -0.53367 8.53732  1.000 55.54880  ? 261 SER A C   1 
ATOM   2315 O O   . SER A 1 266 ? -16.50194 -0.94945 8.53039  1.000 58.22049  ? 261 SER A O   1 
ATOM   2316 C CB  . SER A 1 266 ? -14.07748 -1.96182 10.17984 1.000 56.14970  ? 261 SER A CB  1 
ATOM   2317 O OG  . SER A 1 266 ? -13.91907 -0.87370 11.07806 1.000 49.04677  ? 261 SER A OG  1 
ATOM   2318 N N   . LEU A 1 267 ? -15.04903 0.75367  8.37519  1.000 44.35102  ? 262 LEU A N   1 
ATOM   2319 C CA  . LEU A 1 267 ? -16.10285 1.75322  8.41406  1.000 41.22334  ? 262 LEU A CA  1 
ATOM   2320 C C   . LEU A 1 267 ? -16.78787 1.86756  7.05454  1.000 47.94734  ? 262 LEU A C   1 
ATOM   2321 O O   . LEU A 1 267 ? -16.16169 1.70888  5.99903  1.000 55.62324  ? 262 LEU A O   1 
ATOM   2322 C CB  . LEU A 1 267 ? -15.53663 3.11755  8.84727  1.000 45.54667  ? 262 LEU A CB  1 
ATOM   2323 C CG  . LEU A 1 267 ? -14.72616 3.16997  10.14860 1.000 50.14805  ? 262 LEU A CG  1 
ATOM   2324 C CD1 . LEU A 1 267 ? -13.95455 4.46517  10.28769 1.000 47.15750  ? 262 LEU A CD1 1 
ATOM   2325 C CD2 . LEU A 1 267 ? -15.62750 2.93790  11.34636 1.000 50.51641  ? 262 LEU A CD2 1 
ATOM   2326 N N   . THR A 1 268 ? -18.08399 2.16174  7.09110  1.000 43.14816  ? 263 THR A N   1 
ATOM   2327 C CA  . THR A 1 268 ? -18.81038 2.48576  5.87461  1.000 58.47439  ? 263 THR A CA  1 
ATOM   2328 C C   . THR A 1 268 ? -18.22454 3.74203  5.24500  1.000 47.61914  ? 263 THR A C   1 
ATOM   2329 O O   . THR A 1 268 ? -18.05080 4.76318  5.91326  1.000 44.53702  ? 263 THR A O   1 
ATOM   2330 C CB  . THR A 1 268 ? -20.29552 2.68305  6.19016  1.000 54.20543  ? 263 THR A CB  1 
ATOM   2331 O OG1 . THR A 1 268 ? -20.86978 1.42164  6.54841  1.000 65.09884  ? 263 THR A OG1 1 
ATOM   2332 C CG2 . THR A 1 268 ? -21.04763 3.22475  4.97918  1.000 54.46990  ? 263 THR A CG2 1 
ATOM   2333 N N   . GLN A 1 269 ? -17.92609 3.66926  3.95705  1.000 46.87013  ? 264 GLN A N   1 
ATOM   2334 C CA  . GLN A 1 269 ? -17.34525 4.81686  3.28539  1.000 44.44345  ? 264 GLN A CA  1 
ATOM   2335 C C   . GLN A 1 269 ? -18.33986 5.98385  3.25338  1.000 46.47383  ? 264 GLN A C   1 
ATOM   2336 O O   . GLN A 1 269 ? -19.55896 5.79339  3.16432  1.000 54.13148  ? 264 GLN A O   1 
ATOM   2337 C CB  . GLN A 1 269 ? -16.89539 4.41165  1.88893  1.000 62.69051  ? 264 GLN A CB  1 
ATOM   2338 C CG  . GLN A 1 269 ? -16.09498 3.11276  1.92744  1.000 59.57963  ? 264 GLN A CG  1 
ATOM   2339 C CD  . GLN A 1 269 ? -15.05232 2.97824  0.82686  1.000 62.63714  ? 264 GLN A CD  1 
ATOM   2340 O OE1 . GLN A 1 269 ? -14.57255 3.96864  0.26113  1.000 63.06099  ? 264 GLN A OE1 1 
ATOM   2341 N NE2 . GLN A 1 269 ? -14.72684 1.73746  0.48882  1.000 58.47523  ? 264 GLN A NE2 1 
ATOM   2342 N N   . MET A 1 270 ? -17.80905 7.21048  3.37149  1.000 37.49243  ? 265 MET A N   1 
ATOM   2343 C CA  . MET A 1 270 ? -18.62924 8.42420  3.51767  1.000 45.03125  ? 265 MET A CA  1 
ATOM   2344 C C   . MET A 1 270 ? -17.97111 9.51131  2.66881  1.000 36.39008  ? 265 MET A C   1 
ATOM   2345 O O   . MET A 1 270 ? -16.74211 9.68732  2.74433  1.000 39.44546  ? 265 MET A O   1 
ATOM   2346 C CB  . MET A 1 270 ? -18.66182 8.83046  4.99179  1.000 55.92432  ? 265 MET A CB  1 
ATOM   2347 C CG  . MET A 1 270 ? -19.81816 8.30828  5.79988  1.000 65.85629  ? 265 MET A CG  1 
ATOM   2348 S SD  . MET A 1 270 ? -19.73045 8.86777  7.54140  1.000 57.60536  ? 265 MET A SD  1 
ATOM   2349 C CE  . MET A 1 270 ? -17.96301 8.90675  7.78304  1.000 54.69290  ? 265 MET A CE  1 
ATOM   2350 N N   . PRO A 1 271 ? -18.73288 10.25364 1.87017  1.000 45.74688  ? 266 PRO A N   1 
ATOM   2351 C CA  . PRO A 1 271 ? -18.13961 11.36863 1.13121  1.000 39.49072  ? 266 PRO A CA  1 
ATOM   2352 C C   . PRO A 1 271 ? -17.89326 12.55854 2.04238  1.000 37.66030  ? 266 PRO A C   1 
ATOM   2353 O O   . PRO A 1 271 ? -18.55308 12.74500 3.06502  1.000 41.50473  ? 266 PRO A O   1 
ATOM   2354 C CB  . PRO A 1 271 ? -19.21116 11.69180 0.08085  1.000 35.22416  ? 266 PRO A CB  1 
ATOM   2355 C CG  . PRO A 1 271 ? -20.52434 11.38174 0.82005  1.000 42.96425  ? 266 PRO A CG  1 
ATOM   2356 C CD  . PRO A 1 271 ? -20.20267 10.17732 1.67105  1.000 42.14289  ? 266 PRO A CD  1 
ATOM   2357 N N   . LYS A 1 272 ? -16.95249 13.39306 1.63126  1.000 40.64238  ? 267 LYS A N   1 
ATOM   2358 C CA  . LYS A 1 272 ? -16.74289 14.64506 2.33175  1.000 38.75624  ? 267 LYS A CA  1 
ATOM   2359 C C   . LYS A 1 272 ? -17.99019 15.51109 2.24023  1.000 46.55977  ? 267 LYS A C   1 
ATOM   2360 O O   . LYS A 1 272 ? -18.64368 15.56088 1.20256  1.000 38.99969  ? 267 LYS A O   1 
ATOM   2361 C CB  . LYS A 1 272 ? -15.55357 15.35907 1.72455  1.000 36.36497  ? 267 LYS A CB  1 
ATOM   2362 C CG  . LYS A 1 272 ? -15.41516 16.78290 2.21348  1.000 43.33708  ? 267 LYS A CG  1 
ATOM   2363 C CD  . LYS A 1 272 ? -14.53640 17.57616 1.30387  1.000 56.18716  ? 267 LYS A CD  1 
ATOM   2364 C CE  . LYS A 1 272 ? -15.39890 18.53969 0.56183  1.000 70.73472  ? 267 LYS A CE  1 
ATOM   2365 N NZ  . LYS A 1 272 ? -15.68866 19.76846 1.33687  1.000 58.66231  ? 267 LYS A NZ  1 
ATOM   2366 N N   . MET A 1 273 ? -18.32745 16.18895 3.32953  1.000 34.42824  ? 268 MET A N   1 
ATOM   2367 C CA  . MET A 1 273 ? -19.54390 16.99103 3.40835  1.000 38.64145  ? 268 MET A CA  1 
ATOM   2368 C C   . MET A 1 273 ? -19.33405 18.33755 2.70770  1.000 40.11070  ? 268 MET A C   1 
ATOM   2369 O O   . MET A 1 273 ? -18.20864 18.77944 2.45942  1.000 38.81141  ? 268 MET A O   1 
ATOM   2370 C CB  . MET A 1 273 ? -19.88635 17.20208 4.88376  1.000 40.55087  ? 268 MET A CB  1 
ATOM   2371 C CG  . MET A 1 273 ? -20.53313 15.99318 5.51273  1.000 44.74235  ? 268 MET A CG  1 
ATOM   2372 S SD  . MET A 1 273 ? -21.29876 16.32744 7.10717  1.000 49.25197  ? 268 MET A SD  1 
ATOM   2373 C CE  . MET A 1 273 ? -22.67231 17.36836 6.60026  1.000 55.79274  ? 268 MET A CE  1 
ATOM   2374 N N   . ASN A 1 274 ? -20.44171 18.99450 2.39031  1.000 36.44338  ? 269 ASN A N   1 
ATOM   2375 C CA  . ASN A 1 274 ? -20.40235 20.34568 1.83904  1.000 39.67464  ? 269 ASN A CA  1 
ATOM   2376 C C   . ASN A 1 274 ? -20.18210 21.34087 2.97760  1.000 34.04390  ? 269 ASN A C   1 
ATOM   2377 O O   . ASN A 1 274 ? -21.08455 21.58009 3.77070  1.000 37.74803  ? 269 ASN A O   1 
ATOM   2378 C CB  . ASN A 1 274 ? -21.70636 20.64316 1.09756  1.000 38.51205  ? 269 ASN A CB  1 
ATOM   2379 C CG  . ASN A 1 274 ? -21.68024 21.97926 0.40527  1.000 49.09551  ? 269 ASN A CG  1 
ATOM   2380 O OD1 . ASN A 1 274 ? -21.11449 22.93069 0.92566  1.000 50.41162  ? 269 ASN A OD1 1 
ATOM   2381 N ND2 . ASN A 1 274 ? -22.32329 22.07506 -0.74816 1.000 39.94581  ? 269 ASN A ND2 1 
ATOM   2382 N N   . PHE A 1 275 ? -19.02064 21.98810 3.01644  1.000 31.90750  ? 270 PHE A N   1 
ATOM   2383 C CA  . PHE A 1 275 ? -18.72835 22.89357 4.12616  1.000 41.09359  ? 270 PHE A CA  1 
ATOM   2384 C C   . PHE A 1 275 ? -19.61259 24.13810 4.10680  1.000 41.27731  ? 270 PHE A C   1 
ATOM   2385 O O   . PHE A 1 275 ? -19.86335 24.73116 5.15867  1.000 40.09335  ? 270 PHE A O   1 
ATOM   2386 C CB  . PHE A 1 275 ? -17.26364 23.32778 4.09191  1.000 37.68785  ? 270 PHE A CB  1 
ATOM   2387 C CG  . PHE A 1 275 ? -16.30972 22.32351 4.65600  1.000 40.57429  ? 270 PHE A CG  1 
ATOM   2388 C CD1 . PHE A 1 275 ? -16.52431 20.96675 4.47004  1.000 32.46915  ? 270 PHE A CD1 1 
ATOM   2389 C CD2 . PHE A 1 275 ? -15.17215 22.73945 5.33839  1.000 37.45656  ? 270 PHE A CD2 1 
ATOM   2390 C CE1 . PHE A 1 275 ? -15.65107 20.02367 4.95988  1.000 41.13630  ? 270 PHE A CE1 1 
ATOM   2391 C CE2 . PHE A 1 275 ? -14.27070 21.79753 5.85566  1.000 43.07920  ? 270 PHE A CE2 1 
ATOM   2392 C CZ  . PHE A 1 275 ? -14.51065 20.43136 5.66504  1.000 39.41818  ? 270 PHE A CZ  1 
ATOM   2393 N N   . ALA A 1 276 ? -20.05213 24.59478 2.92969  1.000 39.18240  ? 271 ALA A N   1 
ATOM   2394 C CA  . ALA A 1 276 ? -20.97640 25.72722 2.92333  1.000 40.59583  ? 271 ALA A CA  1 
ATOM   2395 C C   . ALA A 1 276 ? -22.28822 25.39035 3.61993  1.000 45.11499  ? 271 ALA A C   1 
ATOM   2396 O O   . ALA A 1 276 ? -22.94837 26.27832 4.17031  1.000 48.99097  ? 271 ALA A O   1 
ATOM   2397 C CB  . ALA A 1 276 ? -21.25169 26.19915 1.50017  1.000 45.90923  ? 271 ALA A CB  1 
ATOM   2398 N N   . ASN A 1 277 ? -22.69391 24.13060 3.60604  1.000 36.63860  ? 272 ASN A N   1 
ATOM   2399 C CA  . ASN A 1 277 ? -23.89236 23.75354 4.32957  1.000 39.35794  ? 272 ASN A CA  1 
ATOM   2400 C C   . ASN A 1 277 ? -23.64553 23.43156 5.78683  1.000 43.50719  ? 272 ASN A C   1 
ATOM   2401 O O   . ASN A 1 277 ? -24.60179 23.39167 6.55199  1.000 41.77978  ? 272 ASN A O   1 
ATOM   2402 C CB  . ASN A 1 277 ? -24.57175 22.57358 3.64883  1.000 38.30176  ? 272 ASN A CB  1 
ATOM   2403 C CG  . ASN A 1 277 ? -25.17678 22.97285 2.33820  1.000 46.20875  ? 272 ASN A CG  1 
ATOM   2404 O OD1 . ASN A 1 277 ? -25.55586 24.11857 2.18940  1.000 41.93832  ? 272 ASN A OD1 1 
ATOM   2405 N ND2 . ASN A 1 277 ? -25.23850 22.05321 1.37176  1.000 39.27448  ? 272 ASN A ND2 1 
ATOM   2406 N N   A VAL A 1 278 ? -22.40102 23.18862 6.18805  0.690 40.82699  ? 273 VAL A N   1 
ATOM   2407 N N   B VAL A 1 278 ? -22.40253 23.21279 6.20706  0.310 40.77873  ? 273 VAL A N   1 
ATOM   2408 C CA  A VAL A 1 278 ? -22.10124 23.01030 7.60836  0.690 38.52456  ? 273 VAL A CA  1 
ATOM   2409 C CA  B VAL A 1 278 ? -22.17620 23.03313 7.63936  0.310 38.63424  ? 273 VAL A CA  1 
ATOM   2410 C C   A VAL A 1 278 ? -21.89566 24.35523 8.28938  0.690 40.98843  ? 273 VAL A C   1 
ATOM   2411 C C   B VAL A 1 278 ? -21.86029 24.35227 8.33438  0.310 40.97598  ? 273 VAL A C   1 
ATOM   2412 O O   A VAL A 1 278 ? -22.43071 24.59408 9.36753  0.690 42.64685  ? 273 VAL A O   1 
ATOM   2413 O O   B VAL A 1 278 ? -22.26927 24.55669 9.48314  0.310 43.27238  ? 273 VAL A O   1 
ATOM   2414 C CB  A VAL A 1 278 ? -20.87409 22.09409 7.77605  0.690 40.66121  ? 273 VAL A CB  1 
ATOM   2415 C CB  B VAL A 1 278 ? -21.07753 21.99121 7.89823  0.310 41.18102  ? 273 VAL A CB  1 
ATOM   2416 C CG1 A VAL A 1 278 ? -20.37383 22.06814 9.24691  0.690 37.58488  ? 273 VAL A CG1 1 
ATOM   2417 C CG1 B VAL A 1 278 ? -20.45939 21.52920 6.59166  0.310 40.04440  ? 273 VAL A CG1 1 
ATOM   2418 C CG2 A VAL A 1 278 ? -21.18136 20.69541 7.25647  0.690 42.22908  ? 273 VAL A CG2 1 
ATOM   2419 C CG2 B VAL A 1 278 ? -20.03155 22.53100 8.86215  0.310 37.99670  ? 273 VAL A CG2 1 
ATOM   2420 N N   . PHE A 1 279 ? -21.17758 25.27274 7.65576  1.000 38.44700  ? 274 PHE A N   1 
ATOM   2421 C CA  . PHE A 1 279 ? -20.85686 26.57461 8.25252  1.000 37.79988  ? 274 PHE A CA  1 
ATOM   2422 C C   . PHE A 1 279 ? -21.75789 27.66228 7.67009  1.000 36.32986  ? 274 PHE A C   1 
ATOM   2423 O O   . PHE A 1 279 ? -21.32485 28.61771 7.04267  1.000 34.47550  ? 274 PHE A O   1 
ATOM   2424 C CB  . PHE A 1 279 ? -19.38397 26.88668 8.06794  1.000 37.11746  ? 274 PHE A CB  1 
ATOM   2425 C CG  . PHE A 1 279 ? -18.48370 25.86669 8.71420  1.000 45.34327  ? 274 PHE A CG  1 
ATOM   2426 C CD1 . PHE A 1 279 ? -18.30330 25.85294 10.09617 1.000 41.38591  ? 274 PHE A CD1 1 
ATOM   2427 C CD2 . PHE A 1 279 ? -17.88986 24.88192 7.95607  1.000 36.34630  ? 274 PHE A CD2 1 
ATOM   2428 C CE1 . PHE A 1 279 ? -17.47506 24.89589 10.72086 1.000 37.70724  ? 274 PHE A CE1 1 
ATOM   2429 C CE2 . PHE A 1 279 ? -17.06858 23.92075 8.54332  1.000 35.48783  ? 274 PHE A CE2 1 
ATOM   2430 C CZ  . PHE A 1 279 ? -16.85415 23.92239 9.93510  1.000 46.61738  ? 274 PHE A CZ  1 
ATOM   2431 N N   . ILE A 1 280 ? -23.05310 27.51145 7.92863  1.000 45.27839  ? 275 ILE A N   1 
ATOM   2432 C CA  . ILE A 1 280 ? -24.04697 28.38079 7.30281  1.000 42.54157  ? 275 ILE A CA  1 
ATOM   2433 C C   . ILE A 1 280 ? -23.77860 29.83294 7.65298  1.000 43.88982  ? 275 ILE A C   1 
ATOM   2434 O O   . ILE A 1 280 ? -23.58957 30.18182 8.82431  1.000 40.55309  ? 275 ILE A O   1 
ATOM   2435 C CB  . ILE A 1 280 ? -25.45665 27.97691 7.74865  1.000 52.28932  ? 275 ILE A CB  1 
ATOM   2436 C CG1 . ILE A 1 280 ? -25.77645 26.57446 7.25559  1.000 54.00698  ? 275 ILE A CG1 1 
ATOM   2437 C CG2 . ILE A 1 280 ? -26.48714 29.01207 7.27354  1.000 50.66100  ? 275 ILE A CG2 1 
ATOM   2438 C CD1 . ILE A 1 280 ? -26.32899 25.67924 8.33099  1.000 61.15234  ? 275 ILE A CD1 1 
ATOM   2439 N N   . GLY A 1 281 ? -23.79540 30.69616 6.63707  1.000 49.18309  ? 276 GLY A N   1 
ATOM   2440 C CA  . GLY A 1 281 ? -23.60422 32.11548 6.83837  1.000 47.91946  ? 276 GLY A CA  1 
ATOM   2441 C C   . GLY A 1 281 ? -22.16823 32.57636 6.79522  1.000 51.80337  ? 276 GLY A C   1 
ATOM   2442 O O   . GLY A 1 281 ? -21.92097 33.77824 6.68722  1.000 54.77808  ? 276 GLY A O   1 
ATOM   2443 N N   . ALA A 1 282 ? -21.21802 31.65865 6.86287  1.000 42.16228  ? 277 ALA A N   1 
ATOM   2444 C CA  . ALA A 1 282 ? -19.82588 32.03168 6.97839  1.000 41.91625  ? 277 ALA A CA  1 
ATOM   2445 C C   . ALA A 1 282 ? -19.33857 32.66040 5.67752  1.000 37.82078  ? 277 ALA A C   1 
ATOM   2446 O O   . ALA A 1 282 ? -19.75805 32.27776 4.58144  1.000 47.16193  ? 277 ALA A O   1 
ATOM   2447 C CB  . ALA A 1 282 ? -19.00415 30.78354 7.32068  1.000 36.95640  ? 277 ALA A CB  1 
ATOM   2448 N N   . ASN A 1 283 ? -18.44856 33.62026 5.80464  1.000 45.68729  ? 278 ASN A N   1 
ATOM   2449 C CA  . ASN A 1 283 ? -17.64772 34.10984 4.68777  1.000 48.80928  ? 278 ASN A CA  1 
ATOM   2450 C C   . ASN A 1 283 ? -17.21745 32.96284 3.76939  1.000 40.51092  ? 278 ASN A C   1 
ATOM   2451 O O   . ASN A 1 283 ? -16.56551 32.02005 4.23012  1.000 41.39921  ? 278 ASN A O   1 
ATOM   2452 C CB  . ASN A 1 283 ? -16.45259 34.87167 5.27419  1.000 49.06331  ? 278 ASN A CB  1 
ATOM   2453 C CG  . ASN A 1 283 ? -15.70474 35.66040 4.25124  1.000 50.84320  ? 278 ASN A CG  1 
ATOM   2454 O OD1 . ASN A 1 283 ? -15.71141 35.30923 3.07981  1.000 45.43569  ? 278 ASN A OD1 1 
ATOM   2455 N ND2 . ASN A 1 283 ? -15.02572 36.71400 4.68299  1.000 43.28396  ? 278 ASN A ND2 1 
ATOM   2456 N N   . PRO A 1 284 ? -17.56840 32.98783 2.47766  1.000 42.64589  ? 279 PRO A N   1 
ATOM   2457 C CA  . PRO A 1 284 ? -17.11272 31.91492 1.56801  1.000 39.02575  ? 279 PRO A CA  1 
ATOM   2458 C C   . PRO A 1 284 ? -15.60791 31.71948 1.59168  1.000 39.45650  ? 279 PRO A C   1 
ATOM   2459 O O   . PRO A 1 284 ? -15.11088 30.62681 1.30527  1.000 38.69609  ? 279 PRO A O   1 
ATOM   2460 C CB  . PRO A 1 284 ? -17.54688 32.41648 0.18588  1.000 40.54833  ? 279 PRO A CB  1 
ATOM   2461 C CG  . PRO A 1 284 ? -18.76873 33.26046 0.47241  1.000 49.92183  ? 279 PRO A CG  1 
ATOM   2462 C CD  . PRO A 1 284 ? -18.50855 33.91656 1.82138  1.000 58.89395  ? 279 PRO A CD  1 
ATOM   2463 N N   . LEU A 1 285 ? -14.86121 32.76968 1.88002  1.000 38.97375  ? 280 LEU A N   1 
ATOM   2464 C CA  . LEU A 1 285 ? -13.41904 32.60250 1.94357  1.000 37.44737  ? 280 LEU A CA  1 
ATOM   2465 C C   . LEU A 1 285 ? -12.98137 31.88802 3.20702  1.000 38.62146  ? 280 LEU A C   1 
ATOM   2466 O O   . LEU A 1 285 ? -12.01089 31.11474 3.16507  1.000 40.54035  ? 280 LEU A O   1 
ATOM   2467 C CB  . LEU A 1 285 ? -12.73531 33.95192 1.83407  1.000 40.74181  ? 280 LEU A CB  1 
ATOM   2468 C CG  . LEU A 1 285 ? -13.05707 34.72737 0.54679  1.000 46.58006  ? 280 LEU A CG  1 
ATOM   2469 C CD1 . LEU A 1 285 ? -12.83450 36.23194 0.73793  1.000 44.27272  ? 280 LEU A CD1 1 
ATOM   2470 C CD2 . LEU A 1 285 ? -12.29892 34.18236 -0.64988 1.000 49.52041  ? 280 LEU A CD2 1 
ATOM   2471 N N   . ALA A 1 286 ? -13.66341 32.13896 4.33245  1.000 34.56685  ? 281 ALA A N   1 
ATOM   2472 C CA  . ALA A 1 286 ? -13.39769 31.32645 5.51678  1.000 44.35478  ? 281 ALA A CA  1 
ATOM   2473 C C   . ALA A 1 286 ? -13.68878 29.86505 5.23433  1.000 42.43650  ? 281 ALA A C   1 
ATOM   2474 O O   . ALA A 1 286 ? -12.90974 28.98630 5.61556  1.000 41.09526  ? 281 ALA A O   1 
ATOM   2475 C CB  . ALA A 1 286 ? -14.21812 31.80920 6.71334  1.000 36.70560  ? 281 ALA A CB  1 
ATOM   2476 N N   . VAL A 1 287 ? -14.84121 29.58073 4.61810  1.000 38.10948  ? 282 VAL A N   1 
ATOM   2477 C CA  . VAL A 1 287 ? -15.17807 28.20401 4.27844  1.000 34.82033  ? 282 VAL A CA  1 
ATOM   2478 C C   . VAL A 1 287 ? -14.08842 27.60166 3.41435  1.000 42.23671  ? 282 VAL A C   1 
ATOM   2479 O O   . VAL A 1 287 ? -13.61684 26.48700 3.66882  1.000 36.22482  ? 282 VAL A O   1 
ATOM   2480 C CB  . VAL A 1 287 ? -16.54797 28.13768 3.58254  1.000 42.28179  ? 282 VAL A CB  1 
ATOM   2481 C CG1 . VAL A 1 287 ? -16.84261 26.72167 3.09035  1.000 40.68378  ? 282 VAL A CG1 1 
ATOM   2482 C CG2 . VAL A 1 287 ? -17.62179 28.59378 4.52889  1.000 47.07631  ? 282 VAL A CG2 1 
ATOM   2483 N N   . ASP A 1 288 ? -13.67372 28.32578 2.37349  1.000 36.56180  ? 283 ASP A N   1 
ATOM   2484 C CA  . ASP A 1 288 ? -12.62024 27.81426 1.50413  1.000 43.47963  ? 283 ASP A CA  1 
ATOM   2485 C C   . ASP A 1 288 ? -11.36667 27.46767 2.30995  1.000 41.15829  ? 283 ASP A C   1 
ATOM   2486 O O   . ASP A 1 288 ? -10.77784 26.39639 2.13594  1.000 35.88726  ? 283 ASP A O   1 
ATOM   2487 C CB  . ASP A 1 288 ? -12.25918 28.84465 0.43182  1.000 41.79409  ? 283 ASP A CB  1 
ATOM   2488 C CG  . ASP A 1 288 ? -11.25685 28.29762 -0.56404 1.000 48.18079  ? 283 ASP A CG  1 
ATOM   2489 O OD1 . ASP A 1 288 ? -11.54387 27.22889 -1.15044 1.000 53.67516  ? 283 ASP A OD1 1 
ATOM   2490 O OD2 . ASP A 1 288 ? -10.14429 28.86553 -0.69918 1.000 49.32699  ? 283 ASP A OD2 1 
ATOM   2491 N N   . LEU A 1 289 ? -10.92626 28.37815 3.18336  1.000 33.32134  ? 284 LEU A N   1 
ATOM   2492 C CA  . LEU A 1 289 ? -9.71426  28.09847 3.95243  1.000 36.85347  ? 284 LEU A CA  1 
ATOM   2493 C C   . LEU A 1 289 ? -9.90427  26.86674 4.83171  1.000 35.09083  ? 284 LEU A C   1 
ATOM   2494 O O   . LEU A 1 289 ? -9.02664  26.00384 4.91184  1.000 33.17296  ? 284 LEU A O   1 
ATOM   2495 C CB  . LEU A 1 289 ? -9.34445  29.29998 4.80386  1.000 37.81181  ? 284 LEU A CB  1 
ATOM   2496 C CG  . LEU A 1 289 ? -8.08746  29.17809 5.65158  1.000 37.92613  ? 284 LEU A CG  1 
ATOM   2497 C CD1 . LEU A 1 289 ? -6.87238  28.89787 4.74088  1.000 37.35834  ? 284 LEU A CD1 1 
ATOM   2498 C CD2 . LEU A 1 289 ? -7.92793  30.48530 6.40952  1.000 36.19789  ? 284 LEU A CD2 1 
ATOM   2499 N N   A LEU A 1 290 ? -11.05188 26.76086 5.48663  0.760 35.87750  ? 285 LEU A N   1 
ATOM   2500 N N   B LEU A 1 290 ? -11.04549 26.78565 5.52224  0.240 35.86410  ? 285 LEU A N   1 
ATOM   2501 C CA  A LEU A 1 290 ? -11.31079 25.60709 6.33862  0.760 32.38667  ? 285 LEU A CA  1 
ATOM   2502 C CA  B LEU A 1 290 ? -11.34869 25.60819 6.33147  0.240 32.55893  ? 285 LEU A CA  1 
ATOM   2503 C C   A LEU A 1 290 ? -11.21334 24.30809 5.55635  0.760 34.12463  ? 285 LEU A C   1 
ATOM   2504 C C   B LEU A 1 290 ? -11.17801 24.32460 5.53710  0.240 34.24096  ? 285 LEU A C   1 
ATOM   2505 O O   A LEU A 1 290 ? -10.71027 23.30581 6.07192  0.760 36.48820  ? 285 LEU A O   1 
ATOM   2506 O O   B LEU A 1 290 ? -10.61667 23.34353 6.03706  0.240 36.33625  ? 285 LEU A O   1 
ATOM   2507 C CB  A LEU A 1 290 ? -12.68982 25.74028 6.97989  0.760 33.67736  ? 285 LEU A CB  1 
ATOM   2508 C CB  B LEU A 1 290 ? -12.77570 25.68734 6.87642  0.240 33.83309  ? 285 LEU A CB  1 
ATOM   2509 C CG  A LEU A 1 290 ? -12.83015 26.74034 8.12211  0.760 29.13776  ? 285 LEU A CG  1 
ATOM   2510 C CG  B LEU A 1 290 ? -12.99708 25.58606 8.38358  0.240 37.25023  ? 285 LEU A CG  1 
ATOM   2511 C CD1 A LEU A 1 290 ? -14.33589 26.85730 8.44909  0.760 34.00825  ? 285 LEU A CD1 1 
ATOM   2512 C CD1 B LEU A 1 290 ? -11.84501 26.22176 9.15564  0.240 39.97409  ? 285 LEU A CD1 1 
ATOM   2513 C CD2 A LEU A 1 290 ? -12.07463 26.18891 9.33558  0.760 41.14063  ? 285 LEU A CD2 1 
ATOM   2514 C CD2 B LEU A 1 290 ? -14.34490 26.20176 8.76997  0.240 34.36798  ? 285 LEU A CD2 1 
ATOM   2515 N N   . GLU A 1 291 ? -11.66686 24.31041 4.29605  1.000 35.01648  ? 286 GLU A N   1 
ATOM   2516 C CA  . GLU A 1 291 ? -11.58296 23.10761 3.48064  1.000 33.28368  ? 286 GLU A CA  1 
ATOM   2517 C C   . GLU A 1 291 ? -10.14075 22.70919 3.21325  1.000 38.21747  ? 286 GLU A C   1 
ATOM   2518 O O   . GLU A 1 291 ? -9.86655  21.53311 2.99973  1.000 35.32935  ? 286 GLU A O   1 
ATOM   2519 C CB  . GLU A 1 291 ? -12.27325 23.34810 2.15429  1.000 38.42609  ? 286 GLU A CB  1 
ATOM   2520 C CG  . GLU A 1 291 ? -13.77551 23.21204 2.16582  1.000 44.62768  ? 286 GLU A CG  1 
ATOM   2521 C CD  . GLU A 1 291 ? -14.32923 23.69266 0.83860  1.000 57.13531  ? 286 GLU A CD  1 
ATOM   2522 O OE1 . GLU A 1 291 ? -14.22156 22.94615 -0.14834 1.000 70.34010  ? 286 GLU A OE1 1 
ATOM   2523 O OE2 . GLU A 1 291 ? -14.84701 24.82282 0.77584  1.000 69.65523  ? 286 GLU A OE2 1 
ATOM   2524 N N   . LYS A 1 292 ? -9.22203  23.67407 3.16008  1.000 32.90658  ? 287 LYS A N   1 
ATOM   2525 C CA  . LYS A 1 292 ? -7.81291  23.39158 2.90291  1.000 31.46645  ? 287 LYS A CA  1 
ATOM   2526 C C   . LYS A 1 292 ? -7.02426  23.04565 4.15371  1.000 38.68064  ? 287 LYS A C   1 
ATOM   2527 O O   . LYS A 1 292 ? -5.93868  22.46783 4.04491  1.000 35.45633  ? 287 LYS A O   1 
ATOM   2528 C CB  . LYS A 1 292 ? -7.16429  24.58140 2.19028  1.000 33.38049  ? 287 LYS A CB  1 
ATOM   2529 C CG  . LYS A 1 292 ? -7.72718  24.71095 0.76066  1.000 36.83853  ? 287 LYS A CG  1 
ATOM   2530 C CD  . LYS A 1 292 ? -7.30208  25.97832 0.03596  1.000 45.36255  ? 287 LYS A CD  1 
ATOM   2531 C CE  . LYS A 1 292 ? -8.20186  26.21114 -1.16139 1.000 56.13418  ? 287 LYS A CE  1 
ATOM   2532 N NZ  . LYS A 1 292 ? -7.51504  26.99897 -2.20591 1.000 66.26981  ? 287 LYS A NZ  1 
ATOM   2533 N N   . MET A 1 293 ? -7.54549  23.38948 5.32392  1.000 30.89845  ? 288 MET A N   1 
ATOM   2534 C CA  . MET A 1 293 ? -6.86983  23.12305 6.58187  1.000 37.82268  ? 288 MET A CA  1 
ATOM   2535 C C   . MET A 1 293 ? -7.30317  21.75129 7.06003  1.000 39.08893  ? 288 MET A C   1 
ATOM   2536 O O   . MET A 1 293 ? -6.48239  20.94529 7.51211  1.000 35.89901  ? 288 MET A O   1 
ATOM   2537 C CB  . MET A 1 293 ? -7.29571  24.20860 7.56518  1.000 32.84351  ? 288 MET A CB  1 
ATOM   2538 C CG  . MET A 1 293 ? -6.35990  25.40092 7.52616  1.000 34.68200  ? 288 MET A CG  1 
ATOM   2539 S SD  . MET A 1 293 ? -6.69173  26.75326 8.70851  1.000 48.35136  ? 288 MET A SD  1 
ATOM   2540 C CE  . MET A 1 293 ? -8.45183  26.86237 8.75346  1.000 47.77903  ? 288 MET A CE  1 
ATOM   2541 N N   . LEU A 1 294 ? -8.58595  21.44525 6.88812  1.000 34.77041  ? 289 LEU A N   1 
ATOM   2542 C CA  . LEU A 1 294 ? -9.19373  20.24928 7.47366  1.000 32.22764  ? 289 LEU A CA  1 
ATOM   2543 C C   . LEU A 1 294 ? -9.24128  19.13502 6.43745  1.000 39.37498  ? 289 LEU A C   1 
ATOM   2544 O O   . LEU A 1 294 ? -10.29640 18.66078 6.04699  1.000 38.37412  ? 289 LEU A O   1 
ATOM   2545 C CB  . LEU A 1 294 ? -10.58884 20.57184 8.00876  1.000 32.57276  ? 289 LEU A CB  1 
ATOM   2546 C CG  . LEU A 1 294 ? -10.64333 21.52099 9.21272  1.000 25.05482  ? 289 LEU A CG  1 
ATOM   2547 C CD1 . LEU A 1 294 ? -12.09287 21.94216 9.50903  1.000 32.27958  ? 289 LEU A CD1 1 
ATOM   2548 C CD2 . LEU A 1 294 ? -9.98196  20.79142 10.43578 1.000 34.84610  ? 289 LEU A CD2 1 
ATOM   2549 N N   . VAL A 1 295 ? -8.05229  18.79478 5.95783  1.000 34.34291  ? 290 VAL A N   1 
ATOM   2550 C CA  . VAL A 1 295 ? -7.81485  17.70142 5.02610  1.000 38.93590  ? 290 VAL A CA  1 
ATOM   2551 C C   . VAL A 1 295 ? -7.27271  16.52537 5.81859  1.000 40.50657  ? 290 VAL A C   1 
ATOM   2552 O O   . VAL A 1 295 ? -6.39663  16.69260 6.67170  1.000 34.59134  ? 290 VAL A O   1 
ATOM   2553 C CB  . VAL A 1 295 ? -6.83292  18.12437 3.91012  1.000 40.35087  ? 290 VAL A CB  1 
ATOM   2554 C CG1 . VAL A 1 295 ? -6.70933  16.99319 2.88572  1.000 46.40341  ? 290 VAL A CG1 1 
ATOM   2555 C CG2 . VAL A 1 295 ? -7.38316  19.37651 3.20204  1.000 40.72635  ? 290 VAL A CG2 1 
ATOM   2556 N N   . LEU A 1 296 ? -7.85422  15.35109 5.60427  1.000 35.13914  ? 291 LEU A N   1 
ATOM   2557 C CA  . LEU A 1 296 ? -7.40022  14.16957 6.31293  1.000 34.31611  ? 291 LEU A CA  1 
ATOM   2558 C C   . LEU A 1 296 ? -5.93587  13.88265 6.03216  1.000 39.50829  ? 291 LEU A C   1 
ATOM   2559 O O   . LEU A 1 296 ? -5.16184  13.69578 6.96531  1.000 40.77352  ? 291 LEU A O   1 
ATOM   2560 C CB  . LEU A 1 296 ? -8.27400  12.96652 5.95317  1.000 32.83411  ? 291 LEU A CB  1 
ATOM   2561 C CG  . LEU A 1 296 ? -8.33686  11.93485 7.07743  1.000 52.62283  ? 291 LEU A CG  1 
ATOM   2562 C CD1 . LEU A 1 296 ? -8.80182  12.61526 8.36582  1.000 44.33818  ? 291 LEU A CD1 1 
ATOM   2563 C CD2 . LEU A 1 296 ? -9.24347  10.75035 6.71687  1.000 41.76561  ? 291 LEU A CD2 1 
ATOM   2564 N N   . ASP A 1 297 ? -5.53479  13.83732 4.75250  1.000 35.83212  ? 292 ASP A N   1 
ATOM   2565 C CA  . ASP A 1 297 ? -4.14072  13.53583 4.39489  1.000 42.20752  ? 292 ASP A CA  1 
ATOM   2566 C C   . ASP A 1 297 ? -3.25140  14.71927 4.75292  1.000 41.01399  ? 292 ASP A C   1 
ATOM   2567 O O   . ASP A 1 297 ? -3.32562  15.77408 4.10785  1.000 39.55654  ? 292 ASP A O   1 
ATOM   2568 C CB  . ASP A 1 297 ? -4.00520  13.24747 2.90008  1.000 43.19267  ? 292 ASP A CB  1 
ATOM   2569 C CG  . ASP A 1 297 ? -2.69756  12.52185 2.54506  1.000 48.76717  ? 292 ASP A CG  1 
ATOM   2570 O OD1 . ASP A 1 297 ? -1.66422  12.73209 3.24143  1.000 38.85782  ? 292 ASP A OD1 1 
ATOM   2571 O OD2 . ASP A 1 297 ? -2.67659  11.82883 1.49074  1.000 49.72508  ? 292 ASP A OD2 1 
ATOM   2572 N N   . SER A 1 298 ? -2.35950  14.54578 5.73533  1.000 37.57429  ? 293 SER A N   1 
ATOM   2573 C CA  . SER A 1 298 ? -1.62328  15.70552 6.22415  1.000 41.54166  ? 293 SER A CA  1 
ATOM   2574 C C   . SER A 1 298 ? -0.70948  16.27924 5.14516  1.000 39.44694  ? 293 SER A C   1 
ATOM   2575 O O   . SER A 1 298 ? -0.46200  17.48502 5.14660  1.000 41.30041  ? 293 SER A O   1 
ATOM   2576 C CB  . SER A 1 298 ? -0.79095  15.35453 7.45581  1.000 40.40999  ? 293 SER A CB  1 
ATOM   2577 O OG  . SER A 1 298 ? 0.21296   14.42263 7.12679  1.000 39.58147  ? 293 SER A OG  1 
ATOM   2578 N N   . ASP A 1 299 ? -0.20221  15.42980 4.22801  1.000 34.76448  ? 294 ASP A N   1 
ATOM   2579 C CA  . ASP A 1 299 ? 0.60451   15.88023 3.09426  1.000 41.39620  ? 294 ASP A CA  1 
ATOM   2580 C C   . ASP A 1 299 ? -0.08068  16.97059 2.28618  1.000 38.97111  ? 294 ASP A C   1 
ATOM   2581 O O   . ASP A 1 299 ? 0.59652   17.79316 1.66650  1.000 37.39387  ? 294 ASP A O   1 
ATOM   2582 C CB  . ASP A 1 299 ? 0.90972   14.69568 2.17870  1.000 46.14244  ? 294 ASP A CB  1 
ATOM   2583 C CG  . ASP A 1 299 ? 2.03388   13.82170 2.70103  1.000 57.66492  ? 294 ASP A CG  1 
ATOM   2584 O OD1 . ASP A 1 299 ? 2.17423   12.69114 2.14522  1.000 66.20756  ? 294 ASP A OD1 1 
ATOM   2585 O OD2 . ASP A 1 299 ? 2.75679   14.23851 3.65091  1.000 56.09372  ? 294 ASP A OD2 1 
ATOM   2586 N N   . LYS A 1 300 ? -1.40701  16.97969 2.25958  1.000 40.30381  ? 295 LYS A N   1 
ATOM   2587 C CA  . LYS A 1 300 ? -2.20690  17.84071 1.38887  1.000 39.92163  ? 295 LYS A CA  1 
ATOM   2588 C C   . LYS A 1 300 ? -2.74618  19.07195 2.09521  1.000 35.64741  ? 295 LYS A C   1 
ATOM   2589 O O   . LYS A 1 300 ? -3.28621  19.96253 1.43630  1.000 33.91430  ? 295 LYS A O   1 
ATOM   2590 C CB  . LYS A 1 300 ? -3.36396  17.02710 0.81414  1.000 35.87681  ? 295 LYS A CB  1 
ATOM   2591 C CG  . LYS A 1 300 ? -2.90417  15.78662 0.03227  1.000 46.34326  ? 295 LYS A CG  1 
ATOM   2592 C CD  . LYS A 1 300 ? -3.69401  15.59157 -1.23632 1.000 54.04068  ? 295 LYS A CD  1 
ATOM   2593 C CE  . LYS A 1 300 ? -3.09222  14.48594 -2.06343 1.000 69.92572  ? 295 LYS A CE  1 
ATOM   2594 N NZ  . LYS A 1 300 ? -2.60392  14.99950 -3.37939 1.000 88.61664  ? 295 LYS A NZ  1 
ATOM   2595 N N   . ARG A 1 301 ? -2.59073  19.16005 3.40799  1.000 33.83451  ? 296 ARG A N   1 
ATOM   2596 C CA  . ARG A 1 301 ? -3.03829  20.32980 4.14436  1.000 35.38596  ? 296 ARG A CA  1 
ATOM   2597 C C   . ARG A 1 301 ? -2.28531  21.58117 3.69087  1.000 35.83846  ? 296 ARG A C   1 
ATOM   2598 O O   . ARG A 1 301 ? -1.08675  21.53509 3.38236  1.000 34.94134  ? 296 ARG A O   1 
ATOM   2599 C CB  . ARG A 1 301 ? -2.77855  20.08281 5.61823  1.000 39.24863  ? 296 ARG A CB  1 
ATOM   2600 C CG  . ARG A 1 301 ? -3.94641  19.80332 6.43564  1.000 44.33267  ? 296 ARG A CG  1 
ATOM   2601 C CD  . ARG A 1 301 ? -3.55881  19.23034 7.80677  1.000 34.75270  ? 296 ARG A CD  1 
ATOM   2602 N NE  . ARG A 1 301 ? -4.13851  17.91127 8.05827  1.000 36.82312  ? 296 ARG A NE  1 
ATOM   2603 C CZ  . ARG A 1 301 ? -3.70964  17.05216 8.97623  1.000 37.29274  ? 296 ARG A CZ  1 
ATOM   2604 N NH1 . ARG A 1 301 ? -2.74642  17.36764 9.82417  1.000 36.40923  ? 296 ARG A NH1 1 
ATOM   2605 N NH2 . ARG A 1 301 ? -4.26730  15.84728 9.04849  1.000 34.51863  ? 296 ARG A NH2 1 
ATOM   2606 N N   . ILE A 1 302 ? -2.98293  22.71751 3.69841  1.000 35.14967  ? 297 ILE A N   1 
ATOM   2607 C CA  . ILE A 1 302 ? -2.28702  23.99111 3.50630  1.000 40.40940  ? 297 ILE A CA  1 
ATOM   2608 C C   . ILE A 1 302 ? -1.24230  24.15008 4.61436  1.000 35.06504  ? 297 ILE A C   1 
ATOM   2609 O O   . ILE A 1 302 ? -1.42721  23.67218 5.74513  1.000 33.55672  ? 297 ILE A O   1 
ATOM   2610 C CB  . ILE A 1 302 ? -3.28130  25.16900 3.51262  1.000 35.59553  ? 297 ILE A CB  1 
ATOM   2611 C CG1 . ILE A 1 302 ? -2.71427  26.43163 2.82217  1.000 29.86833  ? 297 ILE A CG1 1 
ATOM   2612 C CG2 . ILE A 1 302 ? -3.87270  25.42641 4.93520  1.000 31.78961  ? 297 ILE A CG2 1 
ATOM   2613 C CD1 . ILE A 1 302 ? -3.82174  27.26297 2.15634  1.000 41.82834  ? 297 ILE A CD1 1 
ATOM   2614 N N   . THR A 1 303 ? -0.11934  24.81047 4.28956  1.000 36.22322  ? 298 THR A N   1 
ATOM   2615 C CA  . THR A 1 303 ? 0.86126   25.18175 5.30905  1.000 30.70700  ? 298 THR A CA  1 
ATOM   2616 C C   . THR A 1 303 ? 0.56936   26.57570 5.87743  1.000 32.98499  ? 298 THR A C   1 
ATOM   2617 O O   . THR A 1 303 ? -0.22240  27.34185 5.33212  1.000 34.07959  ? 298 THR A O   1 
ATOM   2618 C CB  . THR A 1 303 ? 2.29307   25.17526 4.74340  1.000 39.92128  ? 298 THR A CB  1 
ATOM   2619 O OG1 . THR A 1 303 ? 2.45991   26.29956 3.86536  1.000 36.80962  ? 298 THR A OG1 1 
ATOM   2620 C CG2 . THR A 1 303 ? 2.58873   23.86258 3.97673  1.000 40.06684  ? 298 THR A CG2 1 
ATOM   2621 N N   . ALA A 1 304 ? 1.25442   26.93203 6.97449  1.000 30.14529  ? 299 ALA A N   1 
ATOM   2622 C CA  . ALA A 1 304 ? 1.01088   28.25802 7.52864  1.000 31.04347  ? 299 ALA A CA  1 
ATOM   2623 C C   . ALA A 1 304 ? 1.44616   29.34830 6.55410  1.000 35.21473  ? 299 ALA A C   1 
ATOM   2624 O O   . ALA A 1 304 ? 0.74821   30.35779 6.38678  1.000 30.92098  ? 299 ALA A O   1 
ATOM   2625 C CB  . ALA A 1 304 ? 1.70833   28.42967 8.87600  1.000 31.00040  ? 299 ALA A CB  1 
ATOM   2626 N N   . ALA A 1 305 ? 2.60234   29.16980 5.90598  1.000 37.34323  ? 300 ALA A N   1 
ATOM   2627 C CA  . ALA A 1 305 ? 3.07010   30.17068 4.94586  1.000 39.54869  ? 300 ALA A CA  1 
ATOM   2628 C C   . ALA A 1 305 ? 2.09129   30.32752 3.78503  1.000 43.97374  ? 300 ALA A C   1 
ATOM   2629 O O   . ALA A 1 305 ? 1.78084   31.44845 3.35902  1.000 40.24071  ? 300 ALA A O   1 
ATOM   2630 C CB  . ALA A 1 305 ? 4.46411   29.78540 4.44169  1.000 39.72740  ? 300 ALA A CB  1 
ATOM   2631 N N   . GLN A 1 306 ? 1.56085   29.21958 3.28644  1.000 41.65458  ? 301 GLN A N   1 
ATOM   2632 C CA  . GLN A 1 306 ? 0.57347   29.29594 2.21632  1.000 36.21323  ? 301 GLN A CA  1 
ATOM   2633 C C   . GLN A 1 306 ? -0.73104  29.93033 2.70322  1.000 39.28997  ? 301 GLN A C   1 
ATOM   2634 O O   . GLN A 1 306 ? -1.34745  30.72354 1.98284  1.000 40.26992  ? 301 GLN A O   1 
ATOM   2635 C CB  . GLN A 1 306 ? 0.31078   27.89006 1.67345  1.000 43.02312  ? 301 GLN A CB  1 
ATOM   2636 C CG  . GLN A 1 306 ? 1.49668   27.29136 0.91900  1.000 35.93605  ? 301 GLN A CG  1 
ATOM   2637 C CD  . GLN A 1 306 ? 1.46478   25.77043 0.92546  1.000 46.99117  ? 301 GLN A CD  1 
ATOM   2638 O OE1 . GLN A 1 306 ? 0.47241   25.15100 1.33855  1.000 39.15247  ? 301 GLN A OE1 1 
ATOM   2639 N NE2 . GLN A 1 306 ? 2.52915   25.15658 0.42958  1.000 39.78031  ? 301 GLN A NE2 1 
ATOM   2640 N N   . ALA A 1 307 ? -1.18743  29.59160 3.92462  1.000 29.78937  ? 302 ALA A N   1 
ATOM   2641 C CA  . ALA A 1 307 ? -2.45192  30.16093 4.41038  1.000 30.56394  ? 302 ALA A CA  1 
ATOM   2642 C C   . ALA A 1 307 ? -2.39727  31.67831 4.59850  1.000 44.16075  ? 302 ALA A C   1 
ATOM   2643 O O   . ALA A 1 307 ? -3.41376  32.35796 4.37865  1.000 35.91833  ? 302 ALA A O   1 
ATOM   2644 C CB  . ALA A 1 307 ? -2.87834  29.48023 5.71913  1.000 29.95535  ? 302 ALA A CB  1 
ATOM   2645 N N   . LEU A 1 308 ? -1.24589  32.22830 5.02118  1.000 36.46180  ? 303 LEU A N   1 
ATOM   2646 C CA  . LEU A 1 308 ? -1.13046  33.67975 5.17186  1.000 35.17563  ? 303 LEU A CA  1 
ATOM   2647 C C   . LEU A 1 308 ? -1.43681  34.41506 3.87083  1.000 34.63205  ? 303 LEU A C   1 
ATOM   2648 O O   . LEU A 1 308 ? -1.90481  35.55544 3.90279  1.000 40.73470  ? 303 LEU A O   1 
ATOM   2649 C CB  . LEU A 1 308 ? 0.26956   34.06935 5.67618  1.000 37.25024  ? 303 LEU A CB  1 
ATOM   2650 C CG  . LEU A 1 308 ? 0.68695   33.74254 7.11875  1.000 37.91509  ? 303 LEU A CG  1 
ATOM   2651 C CD1 . LEU A 1 308 ? 2.18611   33.95095 7.36045  1.000 37.19493  ? 303 LEU A CD1 1 
ATOM   2652 C CD2 . LEU A 1 308 ? -0.11480  34.55076 8.16127  1.000 35.54691  ? 303 LEU A CD2 1 
ATOM   2653 N N   . ALA A 1 309 ? -1.20323  33.78985 2.72803  1.000 36.11208  ? 304 ALA A N   1 
ATOM   2654 C CA  . ALA A 1 309 ? -1.44126  34.44889 1.44633  1.000 38.78287  ? 304 ALA A CA  1 
ATOM   2655 C C   . ALA A 1 309 ? -2.82654  34.16574 0.90710  1.000 41.15200  ? 304 ALA A C   1 
ATOM   2656 O O   . ALA A 1 309 ? -3.15057  34.60322 -0.20064 1.000 37.12181  ? 304 ALA A O   1 
ATOM   2657 C CB  . ALA A 1 309 ? -0.39384  34.02028 0.40399  1.000 41.42336  ? 304 ALA A CB  1 
ATOM   2658 N N   . HIS A 1 310 ? -3.64847  33.46360 1.67289  1.000 31.95948  ? 305 HIS A N   1 
ATOM   2659 C CA  . HIS A 1 310 ? -5.02589  33.20274 1.29345  1.000 42.75545  ? 305 HIS A CA  1 
ATOM   2660 C C   . HIS A 1 310 ? -5.85710  34.47931 1.36020  1.000 43.96927  ? 305 HIS A C   1 
ATOM   2661 O O   . HIS A 1 310 ? -5.66401  35.32645 2.23841  1.000 39.35841  ? 305 HIS A O   1 
ATOM   2662 C CB  . HIS A 1 310 ? -5.62410  32.13535 2.21485  1.000 34.87152  ? 305 HIS A CB  1 
ATOM   2663 C CG  . HIS A 1 310 ? -6.92479  31.56398 1.72868  1.000 37.87568  ? 305 HIS A CG  1 
ATOM   2664 N ND1 . HIS A 1 310 ? -8.14407  32.05237 2.14912  1.000 40.29649  ? 305 HIS A ND1 1 
ATOM   2665 C CD2 . HIS A 1 310 ? -7.20218  30.49000 0.94751  1.000 41.39509  ? 305 HIS A CD2 1 
ATOM   2666 C CE1 . HIS A 1 310 ? -9.11901  31.34031 1.60777  1.000 37.24970  ? 305 HIS A CE1 1 
ATOM   2667 N NE2 . HIS A 1 310 ? -8.57677  30.37873 0.88222  1.000 41.73009  ? 305 HIS A NE2 1 
ATOM   2668 N N   . ALA A 1 311 ? -6.81006  34.60056 0.43485  1.000 41.15332  ? 306 ALA A N   1 
ATOM   2669 C CA  . ALA A 1 311 ? -7.57275  35.83540 0.31875  1.000 42.16112  ? 306 ALA A CA  1 
ATOM   2670 C C   . ALA A 1 311 ? -8.35018  36.14177 1.57999  1.000 35.63744  ? 306 ALA A C   1 
ATOM   2671 O O   . ALA A 1 311 ? -8.66130  37.30413 1.82691  1.000 40.52797  ? 306 ALA A O   1 
ATOM   2672 C CB  . ALA A 1 311 ? -8.52467  35.77030 -0.87502 1.000 47.77676  ? 306 ALA A CB  1 
ATOM   2673 N N   . TYR A 1 312 ? -8.66825  35.13906 2.40346  1.000 38.35950  ? 307 TYR A N   1 
ATOM   2674 C CA  . TYR A 1 312 ? -9.38643  35.44099 3.64142  1.000 42.30520  ? 307 TYR A CA  1 
ATOM   2675 C C   . TYR A 1 312 ? -8.63832  36.48382 4.48830  1.000 41.75722  ? 307 TYR A C   1 
ATOM   2676 O O   . TYR A 1 312 ? -9.26051  37.24683 5.23616  1.000 44.90468  ? 307 TYR A O   1 
ATOM   2677 C CB  . TYR A 1 312 ? -9.61778  34.15117 4.44147  1.000 32.36801  ? 307 TYR A CB  1 
ATOM   2678 C CG  . TYR A 1 312 ? -10.47218 34.33350 5.68660  1.000 35.11330  ? 307 TYR A CG  1 
ATOM   2679 C CD1 . TYR A 1 312 ? -11.67867 34.98864 5.62492  1.000 40.96896  ? 307 TYR A CD1 1 
ATOM   2680 C CD2 . TYR A 1 312 ? -10.07120 33.83073 6.91933  1.000 37.34387  ? 307 TYR A CD2 1 
ATOM   2681 C CE1 . TYR A 1 312 ? -12.48640 35.14317 6.76595  1.000 43.39405  ? 307 TYR A CE1 1 
ATOM   2682 C CE2 . TYR A 1 312 ? -10.84378 33.98933 8.05491  1.000 40.22030  ? 307 TYR A CE2 1 
ATOM   2683 C CZ  . TYR A 1 312 ? -12.05244 34.64182 7.96970  1.000 41.57814  ? 307 TYR A CZ  1 
ATOM   2684 O OH  . TYR A 1 312 ? -12.82109 34.79570 9.08691  1.000 47.31230  ? 307 TYR A OH  1 
ATOM   2685 N N   . PHE A 1 313 ? -7.31313  36.54960 4.37751  1.000 39.89875  ? 308 PHE A N   1 
ATOM   2686 C CA  . PHE A 1 313 ? -6.50843  37.45198 5.20131  1.000 37.43818  ? 308 PHE A CA  1 
ATOM   2687 C C   . PHE A 1 313 ? -6.03276  38.72030 4.46960  1.000 43.05143  ? 308 PHE A C   1 
ATOM   2688 O O   . PHE A 1 313 ? -5.14716  39.42605 4.98366  1.000 44.00139  ? 308 PHE A O   1 
ATOM   2689 C CB  . PHE A 1 313 ? -5.29876  36.68561 5.76258  1.000 34.99373  ? 308 PHE A CB  1 
ATOM   2690 C CG  . PHE A 1 313 ? -5.67436  35.50623 6.58825  1.000 38.92766  ? 308 PHE A CG  1 
ATOM   2691 C CD1 . PHE A 1 313 ? -6.41864  35.66661 7.74119  1.000 42.78454  ? 308 PHE A CD1 1 
ATOM   2692 C CD2 . PHE A 1 313 ? -5.30247  34.22660 6.19593  1.000 36.14494  ? 308 PHE A CD2 1 
ATOM   2693 C CE1 . PHE A 1 313 ? -6.79920  34.55816 8.50499  1.000 38.91292  ? 308 PHE A CE1 1 
ATOM   2694 C CE2 . PHE A 1 313 ? -5.66475  33.11599 6.94856  1.000 35.15524  ? 308 PHE A CE2 1 
ATOM   2695 C CZ  . PHE A 1 313 ? -6.43564  33.28403 8.09523  1.000 31.59260  ? 308 PHE A CZ  1 
ATOM   2696 N N   . ALA A 1 314 ? -6.60960  39.04950 3.30413  1.000 41.38969  ? 309 ALA A N   1 
ATOM   2697 C CA  . ALA A 1 314 ? -6.08162  40.17087 2.51443  1.000 50.86870  ? 309 ALA A CA  1 
ATOM   2698 C C   . ALA A 1 314 ? -5.98033  41.45678 3.33290  1.000 48.21578  ? 309 ALA A C   1 
ATOM   2699 O O   . ALA A 1 314 ? -5.06343  42.26641 3.12070  1.000 51.40042  ? 309 ALA A O   1 
ATOM   2700 C CB  . ALA A 1 314 ? -6.94202  40.40534 1.27136  1.000 48.46177  ? 309 ALA A CB  1 
ATOM   2701 N N   . GLN A 1 315 ? -6.88544  41.63271 4.29908  1.000 45.42627  ? 310 GLN A N   1 
ATOM   2702 C CA  . GLN A 1 315 ? -6.87619  42.80925 5.16251  1.000 48.63672  ? 310 GLN A CA  1 
ATOM   2703 C C   . GLN A 1 315 ? -5.55098  42.94812 5.90542  1.000 55.90918  ? 310 GLN A C   1 
ATOM   2704 O O   . GLN A 1 315 ? -5.06767  44.06349 6.11979  1.000 49.57140  ? 310 GLN A O   1 
ATOM   2705 C CB  . GLN A 1 315 ? -8.01232  42.70066 6.18013  1.000 60.01223  ? 310 GLN A CB  1 
ATOM   2706 C CG  . GLN A 1 315 ? -8.42013  43.98633 6.86032  1.000 75.41677  ? 310 GLN A CG  1 
ATOM   2707 C CD  . GLN A 1 315 ? -9.87890  44.32969 6.60351  1.000 86.26583  ? 310 GLN A CD  1 
ATOM   2708 O OE1 . GLN A 1 315 ? -10.45229 43.94285 5.58210  1.000 95.74101  ? 310 GLN A OE1 1 
ATOM   2709 N NE2 . GLN A 1 315 ? -10.48749 45.05633 7.53438  1.000 86.92529  ? 310 GLN A NE2 1 
ATOM   2710 N N   . TYR A 1 316 ? -4.96591  41.82843 6.34677  1.000 41.31271  ? 311 TYR A N   1 
ATOM   2711 C CA  . TYR A 1 316 ? -3.84812  41.87445 7.28312  1.000 51.74761  ? 311 TYR A CA  1 
ATOM   2712 C C   . TYR A 1 316 ? -2.53816  41.39353 6.69411  1.000 44.75648  ? 311 TYR A C   1 
ATOM   2713 O O   . TYR A 1 316 ? -1.47924  41.68172 7.26511  1.000 44.38551  ? 311 TYR A O   1 
ATOM   2714 C CB  . TYR A 1 316 ? -4.16803  41.04829 8.54873  1.000 49.30974  ? 311 TYR A CB  1 
ATOM   2715 C CG  . TYR A 1 316 ? -5.40820  41.54043 9.27019  1.000 49.03419  ? 311 TYR A CG  1 
ATOM   2716 C CD1 . TYR A 1 316 ? -5.36425  42.70825 10.03761 1.000 51.36426  ? 311 TYR A CD1 1 
ATOM   2717 C CD2 . TYR A 1 316 ? -6.62726  40.87285 9.14788  1.000 51.22884  ? 311 TYR A CD2 1 
ATOM   2718 C CE1 . TYR A 1 316 ? -6.48843  43.19113 10.68280 1.000 53.67921  ? 311 TYR A CE1 1 
ATOM   2719 C CE2 . TYR A 1 316 ? -7.76529  41.33642 9.80216  1.000 44.48085  ? 311 TYR A CE2 1 
ATOM   2720 C CZ  . TYR A 1 316 ? -7.68331  42.51118 10.56372 1.000 51.25434  ? 311 TYR A CZ  1 
ATOM   2721 O OH  . TYR A 1 316 ? -8.80623  42.98903 11.19985 1.000 61.05187  ? 311 TYR A OH  1 
ATOM   2722 N N   . HIS A 1 317 ? -2.58552  40.68549 5.57124  1.000 40.54504  ? 312 HIS A N   1 
ATOM   2723 C CA  . HIS A 1 317 ? -1.39357  40.06166 5.03431  1.000 37.70612  ? 312 HIS A CA  1 
ATOM   2724 C C   . HIS A 1 317 ? -0.37719  41.12174 4.66144  1.000 49.90489  ? 312 HIS A C   1 
ATOM   2725 O O   . HIS A 1 317 ? -0.70709  42.11528 4.00699  1.000 48.45607  ? 312 HIS A O   1 
ATOM   2726 C CB  . HIS A 1 317 ? -1.74112  39.19332 3.82023  1.000 40.62701  ? 312 HIS A CB  1 
ATOM   2727 C CG  . HIS A 1 317 ? -0.56916  38.44677 3.25258  1.000 46.35816  ? 312 HIS A CG  1 
ATOM   2728 N ND1 . HIS A 1 317 ? 0.34701   37.77314 4.03220  1.000 38.73645  ? 312 HIS A ND1 1 
ATOM   2729 C CD2 . HIS A 1 317 ? -0.15568  38.28948 1.97206  1.000 46.79976  ? 312 HIS A CD2 1 
ATOM   2730 C CE1 . HIS A 1 317 ? 1.26666   37.22414 3.26026  1.000 44.76920  ? 312 HIS A CE1 1 
ATOM   2731 N NE2 . HIS A 1 317 ? 0.98892   37.52751 2.00467  1.000 50.12831  ? 312 HIS A NE2 1 
ATOM   2732 N N   . ASP A 1 318 ? 0.85464   40.89531 5.08488  1.000 37.80062  ? 313 ASP A N   1 
ATOM   2733 C CA  . ASP A 1 318 ? 1.97425   41.76804 4.74536  1.000 46.42375  ? 313 ASP A CA  1 
ATOM   2734 C C   . ASP A 1 318 ? 3.16755   40.85281 4.62237  1.000 46.93106  ? 313 ASP A C   1 
ATOM   2735 O O   . ASP A 1 318 ? 3.76205   40.45772 5.63062  1.000 43.00167  ? 313 ASP A O   1 
ATOM   2736 C CB  . ASP A 1 318 ? 2.23197   42.86564 5.77323  1.000 45.95005  ? 313 ASP A CB  1 
ATOM   2737 C CG  . ASP A 1 318 ? 3.34987   43.82308 5.34004  1.000 60.88047  ? 313 ASP A CG  1 
ATOM   2738 O OD1 . ASP A 1 318 ? 4.20699   43.42595 4.51631  1.000 57.28953  ? 313 ASP A OD1 1 
ATOM   2739 O OD2 . ASP A 1 318 ? 3.40027   44.95375 5.86046  1.000 58.59405  ? 313 ASP A OD2 1 
ATOM   2740 N N   . PRO A 1 319 ? 3.58051   40.52724 3.39543  1.000 49.97195  ? 314 PRO A N   1 
ATOM   2741 C CA  . PRO A 1 319 ? 4.68409   39.57577 3.22520  1.000 51.08002  ? 314 PRO A CA  1 
ATOM   2742 C C   . PRO A 1 319 ? 6.00296   40.05397 3.80888  1.000 49.55352  ? 314 PRO A C   1 
ATOM   2743 O O   . PRO A 1 319 ? 6.89144   39.22221 4.04187  1.000 47.64186  ? 314 PRO A O   1 
ATOM   2744 C CB  . PRO A 1 319 ? 4.78837   39.41317 1.69987  1.000 54.16977  ? 314 PRO A CB  1 
ATOM   2745 C CG  . PRO A 1 319 ? 3.62066   40.13449 1.11936  1.000 53.94555  ? 314 PRO A CG  1 
ATOM   2746 C CD  . PRO A 1 319 ? 3.18720   41.15052 2.12213  1.000 56.40147  ? 314 PRO A CD  1 
ATOM   2747 N N   . ASP A 1 320 ? 6.17059   41.35537 4.05023  1.000 52.14651  ? 315 ASP A N   1 
ATOM   2748 C CA  . ASP A 1 320 ? 7.39800   41.85025 4.66892  1.000 53.85635  ? 315 ASP A CA  1 
ATOM   2749 C C   . ASP A 1 320 ? 7.31705   41.96843 6.18392  1.000 54.37094  ? 315 ASP A C   1 
ATOM   2750 O O   . ASP A 1 320 ? 8.29414   42.38368 6.81163  1.000 54.17326  ? 315 ASP A O   1 
ATOM   2751 C CB  . ASP A 1 320 ? 7.77114   43.20566 4.08212  1.000 61.31320  ? 315 ASP A CB  1 
ATOM   2752 C CG  . ASP A 1 320 ? 8.05521   43.11943 2.60947  1.000 67.80811  ? 315 ASP A CG  1 
ATOM   2753 O OD1 . ASP A 1 320 ? 8.85689   42.23765 2.21062  1.000 67.58727  ? 315 ASP A OD1 1 
ATOM   2754 O OD2 . ASP A 1 320 ? 7.47671   43.92675 1.85468  1.000 74.80589  ? 315 ASP A OD2 1 
ATOM   2755 N N   . ASP A 1 321 ? 6.18035   41.64163 6.78313  1.000 54.96474  ? 316 ASP A N   1 
ATOM   2756 C CA  . ASP A 1 321 ? 6.03239   41.63591 8.23046  1.000 53.76883  ? 316 ASP A CA  1 
ATOM   2757 C C   . ASP A 1 321 ? 5.54277   40.28507 8.70899  1.000 42.18595  ? 316 ASP A C   1 
ATOM   2758 O O   . ASP A 1 321 ? 4.74701   40.18871 9.63582  1.000 41.37247  ? 316 ASP A O   1 
ATOM   2759 C CB  . ASP A 1 321 ? 5.10425   42.74972 8.70422  1.000 56.47517  ? 316 ASP A CB  1 
ATOM   2760 C CG  . ASP A 1 321 ? 5.51761   43.29824 10.05070 1.000 65.53388  ? 316 ASP A CG  1 
ATOM   2761 O OD1 . ASP A 1 321 ? 6.73902   43.45941 10.25453 1.000 73.53642  ? 316 ASP A OD1 1 
ATOM   2762 O OD2 . ASP A 1 321 ? 4.63130   43.59275 10.88511 1.000 79.77262  ? 316 ASP A OD2 1 
ATOM   2763 N N   . GLU A 1 322 ? 6.05296   39.21729 8.10847  1.000 43.60489  ? 317 GLU A N   1 
ATOM   2764 C CA  . GLU A 1 322 ? 5.75031   37.85389 8.53273  1.000 36.88551  ? 317 GLU A CA  1 
ATOM   2765 C C   . GLU A 1 322 ? 7.06251   37.09586 8.66865  1.000 40.34565  ? 317 GLU A C   1 
ATOM   2766 O O   . GLU A 1 322 ? 7.40959   36.24215 7.84198  1.000 40.81688  ? 317 GLU A O   1 
ATOM   2767 C CB  . GLU A 1 322 ? 4.77170   37.20498 7.55498  1.000 40.16315  ? 317 GLU A CB  1 
ATOM   2768 C CG  . GLU A 1 322 ? 3.36321   37.81887 7.69111  1.000 40.37560  ? 317 GLU A CG  1 
ATOM   2769 C CD  . GLU A 1 322 ? 2.50186   37.65375 6.43371  1.000 44.83931  ? 317 GLU A CD  1 
ATOM   2770 O OE1 . GLU A 1 322 ? 2.95945   36.95036 5.52563  1.000 48.44927  ? 317 GLU A OE1 1 
ATOM   2771 O OE2 . GLU A 1 322 ? 1.32865   38.11152 6.39058  1.000 38.90894  ? 317 GLU A OE2 1 
ATOM   2772 N N   . PRO A 1 323 ? 7.84002   37.41647 9.69644  1.000 36.27590  ? 318 PRO A N   1 
ATOM   2773 C CA  . PRO A 1 323 ? 9.23294   36.96379 9.73602  1.000 39.78230  ? 318 PRO A CA  1 
ATOM   2774 C C   . PRO A 1 323 ? 9.34842   35.48518 10.03436 1.000 48.17337  ? 318 PRO A C   1 
ATOM   2775 O O   . PRO A 1 323 ? 8.43320   34.86235 10.56697 1.000 43.26502  ? 318 PRO A O   1 
ATOM   2776 C CB  . PRO A 1 323 ? 9.84325   37.81316 10.85344 1.000 46.35683  ? 318 PRO A CB  1 
ATOM   2777 C CG  . PRO A 1 323 ? 8.69489   38.10370 11.76909 1.000 46.43072  ? 318 PRO A CG  1 
ATOM   2778 C CD  . PRO A 1 323 ? 7.50005   38.27559 10.84249 1.000 43.22030  ? 318 PRO A CD  1 
ATOM   2779 N N   . VAL A 1 324 ? 10.48929  34.92963 9.64753  1.000 38.33974  ? 319 VAL A N   1 
ATOM   2780 C CA  . VAL A 1 324 ? 10.86600  33.56409 9.97180  1.000 41.84304  ? 319 VAL A CA  1 
ATOM   2781 C C   . VAL A 1 324 ? 11.85510  33.54776 11.13871 1.000 42.17443  ? 319 VAL A C   1 
ATOM   2782 O O   . VAL A 1 324 ? 12.41460  34.56750 11.53385 1.000 42.91275  ? 319 VAL A O   1 
ATOM   2783 C CB  . VAL A 1 324 ? 11.44881  32.83214 8.73243  1.000 42.60991  ? 319 VAL A CB  1 
ATOM   2784 C CG1 . VAL A 1 324 ? 10.36233  32.59124 7.69568  1.000 49.66086  ? 319 VAL A CG1 1 
ATOM   2785 C CG2 . VAL A 1 324 ? 12.62352  33.65884 8.14147  1.000 44.46336  ? 319 VAL A CG2 1 
ATOM   2786 N N   . ALA A 1 325 ? 12.09626  32.36557 11.68170 1.000 33.71084  ? 320 ALA A N   1 
ATOM   2787 C CA  . ALA A 1 325 ? 12.88329  32.21414 12.88991 1.000 39.52987  ? 320 ALA A CA  1 
ATOM   2788 C C   . ALA A 1 325 ? 14.34662  31.97213 12.54603 1.000 38.75162  ? 320 ALA A C   1 
ATOM   2789 O O   . ALA A 1 325 ? 14.68907  31.49053 11.46298 1.000 38.03846  ? 320 ALA A O   1 
ATOM   2790 C CB  . ALA A 1 325 ? 12.34424  31.05048 13.72748 1.000 37.37570  ? 320 ALA A CB  1 
ATOM   2791 N N   . ASP A 1 326 ? 15.21352  32.35119 13.46743 1.000 39.50663  ? 321 ASP A N   1 
ATOM   2792 C CA  . ASP A 1 326 ? 16.59706  31.89286 13.37179 1.000 37.56398  ? 321 ASP A CA  1 
ATOM   2793 C C   . ASP A 1 326 ? 16.64277  30.37535 13.47652 1.000 42.02605  ? 321 ASP A C   1 
ATOM   2794 O O   . ASP A 1 326 ? 15.75008  29.76237 14.07281 1.000 34.79521  ? 321 ASP A O   1 
ATOM   2795 C CB  . ASP A 1 326 ? 17.46842  32.46309 14.48171 1.000 40.69245  ? 321 ASP A CB  1 
ATOM   2796 C CG  . ASP A 1 326 ? 17.74051  33.93759 14.30735 1.000 64.52559  ? 321 ASP A CG  1 
ATOM   2797 O OD1 . ASP A 1 326 ? 17.49175  34.45093 13.19160 1.000 53.92549  ? 321 ASP A OD1 1 
ATOM   2798 O OD2 . ASP A 1 326 ? 18.21876  34.58050 15.27421 1.000 75.53594  ? 321 ASP A OD2 1 
ATOM   2799 N N   . PRO A 1 327 ? 17.68073  29.75490 12.91480 1.000 44.09195  ? 322 PRO A N   1 
ATOM   2800 C CA  . PRO A 1 327 ? 17.84024  28.30313 13.02505 1.000 33.70846  ? 322 PRO A CA  1 
ATOM   2801 C C   . PRO A 1 327 ? 17.78867  27.85751 14.47381 1.000 38.76604  ? 322 PRO A C   1 
ATOM   2802 O O   . PRO A 1 327 ? 18.29013  28.53603 15.37280 1.000 38.64560  ? 322 PRO A O   1 
ATOM   2803 C CB  . PRO A 1 327 ? 19.22197  28.05241 12.39663 1.000 44.94644  ? 322 PRO A CB  1 
ATOM   2804 C CG  . PRO A 1 327 ? 19.42330  29.24592 11.47829 1.000 49.20069  ? 322 PRO A CG  1 
ATOM   2805 C CD  . PRO A 1 327 ? 18.78108  30.39221 12.16883 1.000 45.24414  ? 322 PRO A CD  1 
ATOM   2806 N N   . TYR A 1 328 ? 17.19118  26.69124 14.69147 1.000 35.95045  ? 323 TYR A N   1 
ATOM   2807 C CA  . TYR A 1 328 ? 17.00383  26.16347 16.03785 1.000 45.80676  ? 323 TYR A CA  1 
ATOM   2808 C C   . TYR A 1 328 ? 17.57976  24.75676 16.06271 1.000 44.20459  ? 323 TYR A C   1 
ATOM   2809 O O   . TYR A 1 328 ? 17.05192  23.85094 15.41265 1.000 50.88836  ? 323 TYR A O   1 
ATOM   2810 C CB  . TYR A 1 328 ? 15.52436  26.17781 16.42664 1.000 43.47966  ? 323 TYR A CB  1 
ATOM   2811 C CG  . TYR A 1 328 ? 15.23532  25.51290 17.75663 1.000 42.13039  ? 323 TYR A CG  1 
ATOM   2812 C CD1 . TYR A 1 328 ? 15.72218  26.04056 18.94332 1.000 46.63271  ? 323 TYR A CD1 1 
ATOM   2813 C CD2 . TYR A 1 328 ? 14.46346  24.36556 17.82486 1.000 39.36137  ? 323 TYR A CD2 1 
ATOM   2814 C CE1 . TYR A 1 328 ? 15.44750  25.43075 20.16132 1.000 46.79201  ? 323 TYR A CE1 1 
ATOM   2815 C CE2 . TYR A 1 328 ? 14.20873  23.74231 19.02756 1.000 42.62970  ? 323 TYR A CE2 1 
ATOM   2816 C CZ  . TYR A 1 328 ? 14.69163  24.28987 20.19602 1.000 40.69225  ? 323 TYR A CZ  1 
ATOM   2817 O OH  . TYR A 1 328 ? 14.41917  23.66662 21.39959 1.000 47.58085  ? 323 TYR A OH  1 
ATOM   2818 N N   . ASP A 1 329 ? 18.67937  24.57315 16.77779 1.000 43.17868  ? 324 ASP A N   1 
ATOM   2819 C CA  . ASP A 1 329 ? 19.37824  23.29368 16.76654 1.000 36.54081  ? 324 ASP A CA  1 
ATOM   2820 C C   . ASP A 1 329 ? 18.76290  22.39069 17.81234 1.000 35.13385  ? 324 ASP A C   1 
ATOM   2821 O O   . ASP A 1 329 ? 18.92817  22.62246 19.01395 1.000 38.76972  ? 324 ASP A O   1 
ATOM   2822 C CB  . ASP A 1 329 ? 20.88524  23.51221 16.92351 1.000 40.09651  ? 324 ASP A CB  1 
ATOM   2823 C CG  . ASP A 1 329 ? 21.64946  22.22881 17.23713 1.000 51.03567  ? 324 ASP A CG  1 
ATOM   2824 O OD1 . ASP A 1 329 ? 21.09947  21.11555 17.12279 1.000 53.24239  ? 324 ASP A OD1 1 
ATOM   2825 O OD2 . ASP A 1 329 ? 22.88072  22.34107 17.41307 1.000 52.63110  ? 324 ASP A OD2 1 
ATOM   2826 N N   . GLN A 1 330 ? 18.03754  21.36587 17.34578 1.000 39.92748  ? 325 GLN A N   1 
ATOM   2827 C CA  . GLN A 1 330 ? 17.40280  20.37753 18.20849 1.000 40.26633  ? 325 GLN A CA  1 
ATOM   2828 C C   . GLN A 1 330 ? 18.14392  19.05523 18.24466 1.000 37.52689  ? 325 GLN A C   1 
ATOM   2829 O O   . GLN A 1 330 ? 17.54354  18.03769 18.62679 1.000 38.23451  ? 325 GLN A O   1 
ATOM   2830 C CB  . GLN A 1 330 ? 15.96772  20.06522 17.78463 1.000 48.23986  ? 325 GLN A CB  1 
ATOM   2831 C CG  . GLN A 1 330 ? 15.11344  21.23190 17.41771 1.000 60.44809  ? 325 GLN A CG  1 
ATOM   2832 C CD  . GLN A 1 330 ? 13.66006  20.83613 17.29899 1.000 61.85131  ? 325 GLN A CD  1 
ATOM   2833 O OE1 . GLN A 1 330 ? 13.18381  19.96786 18.04514 1.000 54.23080  ? 325 GLN A OE1 1 
ATOM   2834 N NE2 . GLN A 1 330 ? 12.95787  21.43278 16.34552 1.000 52.92913  ? 325 GLN A NE2 1 
ATOM   2835 N N   . SER A 1 331 ? 19.44142  19.04995 17.90722 1.000 41.38666  ? 326 SER A N   1 
ATOM   2836 C CA  . SER A 1 331 ? 20.16323  17.78901 17.91238 1.000 38.76126  ? 326 SER A CA  1 
ATOM   2837 C C   . SER A 1 331 ? 20.15758  17.16333 19.29177 1.000 46.12254  ? 326 SER A C   1 
ATOM   2838 O O   . SER A 1 331 ? 20.23968  15.93809 19.40332 1.000 38.66726  ? 326 SER A O   1 
ATOM   2839 C CB  . SER A 1 331 ? 21.60742  17.98970 17.42459 1.000 44.78489  ? 326 SER A CB  1 
ATOM   2840 O OG  . SER A 1 331 ? 22.28410  18.79782 18.36534 1.000 39.02057  ? 326 SER A OG  1 
ATOM   2841 N N   . PHE A 1 332 ? 20.05283  17.97716 20.35498 1.000 40.55211  ? 327 PHE A N   1 
ATOM   2842 C CA  . PHE A 1 332 ? 19.99378  17.41200 21.69871 1.000 38.14468  ? 327 PHE A CA  1 
ATOM   2843 C C   . PHE A 1 332 ? 18.81730  16.45065 21.86776 1.000 34.79650  ? 327 PHE A C   1 
ATOM   2844 O O   . PHE A 1 332 ? 18.87676  15.56059 22.71309 1.000 39.13330  ? 327 PHE A O   1 
ATOM   2845 C CB  . PHE A 1 332 ? 19.88943  18.52160 22.75137 1.000 33.29777  ? 327 PHE A CB  1 
ATOM   2846 C CG  . PHE A 1 332 ? 18.49656  19.15911 22.84515 1.000 41.52402  ? 327 PHE A CG  1 
ATOM   2847 C CD1 . PHE A 1 332 ? 17.53669  18.61502 23.67696 1.000 37.41020  ? 327 PHE A CD1 1 
ATOM   2848 C CD2 . PHE A 1 332 ? 18.16176  20.26516 22.09270 1.000 39.03177  ? 327 PHE A CD2 1 
ATOM   2849 C CE1 . PHE A 1 332 ? 16.27531  19.16536 23.77030 1.000 36.48129  ? 327 PHE A CE1 1 
ATOM   2850 C CE2 . PHE A 1 332 ? 16.90658  20.84382 22.18623 1.000 44.46497  ? 327 PHE A CE2 1 
ATOM   2851 C CZ  . PHE A 1 332 ? 15.95361  20.28660 23.01236 1.000 40.68219  ? 327 PHE A CZ  1 
ATOM   2852 N N   . GLU A 1 333 ? 17.77216  16.56577 21.05999 1.000 43.00269  ? 328 GLU A N   1 
ATOM   2853 C CA  . GLU A 1 333 ? 16.63463  15.67982 21.26718 1.000 47.25640  ? 328 GLU A CA  1 
ATOM   2854 C C   . GLU A 1 333 ? 16.99743  14.22221 21.02981 1.000 44.33367  ? 328 GLU A C   1 
ATOM   2855 O O   . GLU A 1 333 ? 16.27873  13.34273 21.50159 1.000 41.73982  ? 328 GLU A O   1 
ATOM   2856 C CB  . GLU A 1 333 ? 15.48225  16.09204 20.36721 1.000 40.09540  ? 328 GLU A CB  1 
ATOM   2857 C CG  . GLU A 1 333 ? 14.84838  17.42969 20.75444 1.000 44.18777  ? 328 GLU A CG  1 
ATOM   2858 C CD  . GLU A 1 333 ? 13.86116  17.28922 21.91275 1.000 51.66781  ? 328 GLU A CD  1 
ATOM   2859 O OE1 . GLU A 1 333 ? 13.87187  16.22989 22.57616 1.000 44.62620  ? 328 GLU A OE1 1 
ATOM   2860 O OE2 . GLU A 1 333 ? 13.06750  18.22633 22.15952 1.000 50.47649  ? 328 GLU A OE2 1 
ATOM   2861 N N   . SER A 1 334 ? 18.10558  13.95227 20.33241 1.000 46.16947  ? 329 SER A N   1 
ATOM   2862 C CA  . SER A 1 334 ? 18.56575  12.60116 20.04256 1.000 47.57472  ? 329 SER A CA  1 
ATOM   2863 C C   . SER A 1 334 ? 19.62782  12.11653 21.00917 1.000 55.03836  ? 329 SER A C   1 
ATOM   2864 O O   . SER A 1 334 ? 20.02025  10.95023 20.92900 1.000 56.23975  ? 329 SER A O   1 
ATOM   2865 C CB  . SER A 1 334 ? 19.14745  12.53076 18.62658 1.000 49.41843  ? 329 SER A CB  1 
ATOM   2866 O OG  . SER A 1 334 ? 18.20447  12.97779 17.68061 1.000 65.09206  ? 329 SER A OG  1 
ATOM   2867 N N   . ARG A 1 335 ? 20.11784  12.98059 21.89338 1.000 45.88071  ? 330 ARG A N   1 
ATOM   2868 C CA  . ARG A 1 335 ? 21.23464  12.62487 22.75654 1.000 44.94554  ? 330 ARG A CA  1 
ATOM   2869 C C   . ARG A 1 335 ? 20.74737  11.90870 23.99510 1.000 43.04627  ? 330 ARG A C   1 
ATOM   2870 O O   . ARG A 1 335 ? 19.72029  12.27007 24.57719 1.000 46.62729  ? 330 ARG A O   1 
ATOM   2871 C CB  . ARG A 1 335 ? 22.01008  13.86135 23.19473 1.000 45.57930  ? 330 ARG A CB  1 
ATOM   2872 C CG  . ARG A 1 335 ? 22.70235  14.54550 22.12400 1.000 61.77272  ? 330 ARG A CG  1 
ATOM   2873 C CD  . ARG A 1 335 ? 23.71237  15.53722 22.65042 1.000 44.00737  ? 330 ARG A CD  1 
ATOM   2874 N NE  . ARG A 1 335 ? 23.76708  16.61979 21.67522 1.000 44.87704  ? 330 ARG A NE  1 
ATOM   2875 C CZ  . ARG A 1 335 ? 23.55215  17.89391 21.95620 1.000 52.69497  ? 330 ARG A CZ  1 
ATOM   2876 N NH1 . ARG A 1 335 ? 23.35179  18.30957 23.20833 1.000 38.69556  ? 330 ARG A NH1 1 
ATOM   2877 N NH2 . ARG A 1 335 ? 23.58212  18.77794 20.96782 1.000 46.45460  ? 330 ARG A NH2 1 
ATOM   2878 N N   . ASP A 1 336 ? 21.49101  10.89551 24.40049 1.000 50.77271  ? 331 ASP A N   1 
ATOM   2879 C CA  . ASP A 1 336 ? 21.28395  10.27294 25.69662 1.000 59.85280  ? 331 ASP A CA  1 
ATOM   2880 C C   . ASP A 1 336 ? 22.34577  10.78676 26.64884 1.000 60.23660  ? 331 ASP A C   1 
ATOM   2881 O O   . ASP A 1 336 ? 23.54001  10.57990 26.41698 1.000 58.31695  ? 331 ASP A O   1 
ATOM   2882 C CB  . ASP A 1 336 ? 21.30572  8.75444  25.57563 1.000 56.11977  ? 331 ASP A CB  1 
ATOM   2883 C CG  . ASP A 1 336 ? 20.23363  8.24749  24.61244 1.000 77.81297  ? 331 ASP A CG  1 
ATOM   2884 O OD1 . ASP A 1 336 ? 19.48627  9.09708  24.06656 1.000 81.53961  ? 331 ASP A OD1 1 
ATOM   2885 O OD2 . ASP A 1 336 ? 20.11602  7.01905  24.40757 1.000 89.16792  ? 331 ASP A OD2 1 
ATOM   2886 N N   . LEU A 1 337 ? 21.91058  11.51594 27.67164 1.000 45.20708  ? 332 LEU A N   1 
ATOM   2887 C CA  . LEU A 1 337 ? 22.81111  12.06272 28.66327 1.000 43.25756  ? 332 LEU A CA  1 
ATOM   2888 C C   . LEU A 1 337 ? 22.32762  11.69087 30.05039 1.000 44.37364  ? 332 LEU A C   1 
ATOM   2889 O O   . LEU A 1 337 ? 21.16435  11.34332 30.24914 1.000 51.57621  ? 332 LEU A O   1 
ATOM   2890 C CB  . LEU A 1 337 ? 22.91207  13.58350 28.57483 1.000 44.74739  ? 332 LEU A CB  1 
ATOM   2891 C CG  . LEU A 1 337 ? 23.46799  14.13254 27.25605 1.000 42.47754  ? 332 LEU A CG  1 
ATOM   2892 C CD1 . LEU A 1 337 ? 23.21448  15.62648 27.20112 1.000 39.30267  ? 332 LEU A CD1 1 
ATOM   2893 C CD2 . LEU A 1 337 ? 24.94768  13.77398 27.06719 1.000 43.73749  ? 332 LEU A CD2 1 
ATOM   2894 N N   . LEU A 1 338 ? 23.22766  11.82645 31.02089 1.000 40.87306  ? 333 LEU A N   1 
ATOM   2895 C CA  . LEU A 1 338 ? 22.86454  11.57475 32.40362 1.000 46.54984  ? 333 LEU A CA  1 
ATOM   2896 C C   . LEU A 1 338 ? 22.19449  12.80146 33.00109 1.000 47.75793  ? 333 LEU A C   1 
ATOM   2897 O O   . LEU A 1 338 ? 22.29784  13.90796 32.46623 1.000 41.31667  ? 333 LEU A O   1 
ATOM   2898 C CB  . LEU A 1 338 ? 24.09954  11.19273 33.21070 1.000 52.64622  ? 333 LEU A CB  1 
ATOM   2899 C CG  . LEU A 1 338 ? 24.92617  10.06682 32.58922 1.000 49.77447  ? 333 LEU A CG  1 
ATOM   2900 C CD1 . LEU A 1 338 ? 26.13588  9.72563  33.46221 1.000 53.24577  ? 333 LEU A CD1 1 
ATOM   2901 C CD2 . LEU A 1 338 ? 24.04704  8.83680  32.37385 1.000 66.45115  ? 333 LEU A CD2 1 
ATOM   2902 N N   . ILE A 1 339 ? 21.49440  12.59220 34.12341 1.000 40.63237  ? 334 ILE A N   1 
ATOM   2903 C CA  . ILE A 1 339 ? 20.79978  13.69720 34.79320 1.000 37.51420  ? 334 ILE A CA  1 
ATOM   2904 C C   . ILE A 1 339 ? 21.74365  14.86999 34.98169 1.000 38.81704  ? 334 ILE A C   1 
ATOM   2905 O O   . ILE A 1 339 ? 21.42926  16.01617 34.62787 1.000 42.94900  ? 334 ILE A O   1 
ATOM   2906 C CB  . ILE A 1 339 ? 20.22156  13.23445 36.14872 1.000 50.20732  ? 334 ILE A CB  1 
ATOM   2907 C CG1 . ILE A 1 339 ? 19.07341  12.26108 35.95272 1.000 48.91649  ? 334 ILE A CG1 1 
ATOM   2908 C CG2 . ILE A 1 339 ? 19.73537  14.41761 36.97423 1.000 43.96576  ? 334 ILE A CG2 1 
ATOM   2909 C CD1 . ILE A 1 339 ? 18.40069  11.86362 37.26726 1.000 60.38056  ? 334 ILE A CD1 1 
ATOM   2910 N N   . ASP A 1 340 ? 22.92476  14.59297 35.54249 1.000 47.21367  ? 335 ASP A N   1 
ATOM   2911 C CA  . ASP A 1 340 ? 23.90876  15.64195 35.79794 1.000 47.98389  ? 335 ASP A CA  1 
ATOM   2912 C C   . ASP A 1 340 ? 24.27736  16.40686 34.53939 1.000 49.92073  ? 335 ASP A C   1 
ATOM   2913 O O   . ASP A 1 340 ? 24.59952  17.59853 34.61738 1.000 41.78678  ? 335 ASP A O   1 
ATOM   2914 C CB  . ASP A 1 340 ? 25.18062  15.04748 36.39357 1.000 56.06908  ? 335 ASP A CB  1 
ATOM   2915 C CG  . ASP A 1 340 ? 25.02726  14.70432 37.87020 1.000 88.76127  ? 335 ASP A CG  1 
ATOM   2916 O OD1 . ASP A 1 340 ? 24.52758  15.56643 38.63274 1.000 76.63726  ? 335 ASP A OD1 1 
ATOM   2917 O OD2 . ASP A 1 340 ? 25.40732  13.57150 38.26373 1.000 91.36499  ? 335 ASP A OD2 1 
ATOM   2918 N N   . GLU A 1 341 ? 24.28526  15.73341 33.38380 1.000 42.85794  ? 336 GLU A N   1 
ATOM   2919 C CA  . GLU A 1 341 ? 24.73793  16.39204 32.16802 1.000 41.21551  ? 336 GLU A CA  1 
ATOM   2920 C C   . GLU A 1 341 ? 23.67207  17.32621 31.61685 1.000 33.78155  ? 336 GLU A C   1 
ATOM   2921 O O   . GLU A 1 341 ? 24.00233  18.41135 31.11780 1.000 38.01317  ? 336 GLU A O   1 
ATOM   2922 C CB  . GLU A 1 341 ? 25.16694  15.33482 31.14558 1.000 46.70470  ? 336 GLU A CB  1 
ATOM   2923 C CG  . GLU A 1 341 ? 26.35713  14.51428 31.68168 1.000 43.11488  ? 336 GLU A CG  1 
ATOM   2924 C CD  . GLU A 1 341 ? 26.75919  13.31485 30.82870 1.000 55.38520  ? 336 GLU A CD  1 
ATOM   2925 O OE1 . GLU A 1 341 ? 25.89215  12.54907 30.36048 1.000 48.27095  ? 336 GLU A OE1 1 
ATOM   2926 O OE2 . GLU A 1 341 ? 27.98333  13.14136 30.64429 1.000 52.53160  ? 336 GLU A OE2 1 
ATOM   2927 N N   . TRP A 1 342 ? 22.39826  16.90435 31.65473 1.000 35.88127  ? 337 TRP A N   1 
ATOM   2928 C CA  . TRP A 1 342 ? 21.30621  17.79981 31.27663 1.000 36.31230  ? 337 TRP A CA  1 
ATOM   2929 C C   . TRP A 1 342 ? 21.26086  19.00099 32.19691 1.000 35.10906  ? 337 TRP A C   1 
ATOM   2930 O O   . TRP A 1 342 ? 21.11482  20.15046 31.75312 1.000 38.92739  ? 337 TRP A O   1 
ATOM   2931 C CB  . TRP A 1 342 ? 19.96770  17.06501 31.33696 1.000 36.20917  ? 337 TRP A CB  1 
ATOM   2932 C CG  . TRP A 1 342 ? 19.79730  16.02825 30.27659 1.000 37.41011  ? 337 TRP A CG  1 
ATOM   2933 C CD1 . TRP A 1 342 ? 19.62713  14.68968 30.46447 1.000 31.34399  ? 337 TRP A CD1 1 
ATOM   2934 C CD2 . TRP A 1 342 ? 19.74800  16.25144 28.85595 1.000 34.93718  ? 337 TRP A CD2 1 
ATOM   2935 N NE1 . TRP A 1 342 ? 19.44320  14.06371 29.24697 1.000 35.59038  ? 337 TRP A NE1 1 
ATOM   2936 C CE2 . TRP A 1 342 ? 19.54583  14.98958 28.24325 1.000 34.71016  ? 337 TRP A CE2 1 
ATOM   2937 C CE3 . TRP A 1 342 ? 19.88556  17.39038 28.04569 1.000 42.71660  ? 337 TRP A CE3 1 
ATOM   2938 C CZ2 . TRP A 1 342 ? 19.46996  14.82562 26.86065 1.000 35.66688  ? 337 TRP A CZ2 1 
ATOM   2939 C CZ3 . TRP A 1 342 ? 19.80560  17.23509 26.67539 1.000 34.94537  ? 337 TRP A CZ3 1 
ATOM   2940 C CH2 . TRP A 1 342 ? 19.59205  15.95011 26.09475 1.000 32.27388  ? 337 TRP A CH2 1 
ATOM   2941 N N   . LYS A 1 343 ? 21.40392  18.74520 33.48955 1.000 46.44826  ? 338 LYS A N   1 
ATOM   2942 C CA  . LYS A 1 343 ? 21.41783  19.81419 34.47757 1.000 36.97822  ? 338 LYS A CA  1 
ATOM   2943 C C   . LYS A 1 343 ? 22.48672  20.83411 34.15552 1.000 50.14573  ? 338 LYS A C   1 
ATOM   2944 O O   . LYS A 1 343 ? 22.23432  22.04596 34.18328 1.000 45.22105  ? 338 LYS A O   1 
ATOM   2945 C CB  . LYS A 1 343 ? 21.64122  19.21223 35.86453 1.000 50.62852  ? 338 LYS A CB  1 
ATOM   2946 C CG  . LYS A 1 343 ? 21.42926  20.17394 37.01242 1.000 56.58601  ? 338 LYS A CG  1 
ATOM   2947 C CD  . LYS A 1 343 ? 21.41116  19.43517 38.34862 1.000 57.76558  ? 338 LYS A CD  1 
ATOM   2948 C CE  . LYS A 1 343 ? 21.72363  20.37816 39.47783 1.000 51.79344  ? 338 LYS A CE  1 
ATOM   2949 N NZ  . LYS A 1 343 ? 21.24806  19.86624 40.79916 1.000 66.67403  ? 338 LYS A NZ  1 
ATOM   2950 N N   . SER A 1 344 ? 23.69867  20.36409 33.84093 1.000 42.25663  ? 339 SER A N   1 
ATOM   2951 C CA  . SER A 1 344 ? 24.75415  21.30735 33.52277 1.000 38.74693  ? 339 SER A CA  1 
ATOM   2952 C C   . SER A 1 344 ? 24.43735  22.07393 32.23973 1.000 41.77483  ? 339 SER A C   1 
ATOM   2953 O O   . SER A 1 344 ? 24.70030  23.27966 32.15181 1.000 39.38204  ? 339 SER A O   1 
ATOM   2954 C CB  . SER A 1 344 ? 26.10279  20.59100 33.40296 1.000 53.70117  ? 339 SER A CB  1 
ATOM   2955 O OG  . SER A 1 344 ? 27.06942  21.41334 32.73367 1.000 47.00871  ? 339 SER A OG  1 
ATOM   2956 N N   . LEU A 1 345 ? 23.91188  21.38849 31.21621 1.000 40.67277  ? 340 LEU A N   1 
ATOM   2957 C CA  . LEU A 1 345 ? 23.44881  22.09811 30.02754 1.000 33.98543  ? 340 LEU A CA  1 
ATOM   2958 C C   . LEU A 1 345 ? 22.43837  23.18027 30.41041 1.000 34.44210  ? 340 LEU A C   1 
ATOM   2959 O O   . LEU A 1 345 ? 22.50498  24.31444 29.92399 1.000 38.74733  ? 340 LEU A O   1 
ATOM   2960 C CB  . LEU A 1 345 ? 22.83785  21.10131 29.03241 1.000 32.87494  ? 340 LEU A CB  1 
ATOM   2961 C CG  . LEU A 1 345 ? 23.79973  20.11358 28.33897 1.000 37.81354  ? 340 LEU A CG  1 
ATOM   2962 C CD1 . LEU A 1 345 ? 23.08195  19.30207 27.31124 1.000 40.28740  ? 340 LEU A CD1 1 
ATOM   2963 C CD2 . LEU A 1 345 ? 24.88351  20.95350 27.64548 1.000 44.88330  ? 340 LEU A CD2 1 
ATOM   2964 N N   . THR A 1 346 ? 21.51256  22.85752 31.30246 1.000 37.74376  ? 341 THR A N   1 
ATOM   2965 C CA  . THR A 1 346 ? 20.49527  23.83813 31.69594 1.000 36.18542  ? 341 THR A CA  1 
ATOM   2966 C C   . THR A 1 346 ? 21.12763  25.03331 32.41244 1.000 34.02058  ? 341 THR A C   1 
ATOM   2967 O O   . THR A 1 346 ? 20.82779  26.19849 32.10964 1.000 37.77936  ? 341 THR A O   1 
ATOM   2968 C CB  . THR A 1 346 ? 19.43394  23.14293 32.56046 1.000 36.94299  ? 341 THR A CB  1 
ATOM   2969 O OG1 . THR A 1 346 ? 18.82387  22.08084 31.79409 1.000 37.32295  ? 341 THR A OG1 1 
ATOM   2970 C CG2 . THR A 1 346 ? 18.35212  24.13509 33.06183 1.000 36.12354  ? 341 THR A CG2 1 
ATOM   2971 N N   . TYR A 1 347 ? 22.04007  24.75879 33.33788 1.000 36.35727  ? 342 TYR A N   1 
ATOM   2972 C CA  . TYR A 1 347 ? 22.73143  25.82865 34.04998 1.000 33.00933  ? 342 TYR A CA  1 
ATOM   2973 C C   . TYR A 1 347 ? 23.40831  26.79541 33.07472 1.000 37.96998  ? 342 TYR A C   1 
ATOM   2974 O O   . TYR A 1 347 ? 23.26961  28.02145 33.18992 1.000 41.02500  ? 342 TYR A O   1 
ATOM   2975 C CB  . TYR A 1 347 ? 23.74679  25.22090 35.03035 1.000 41.01417  ? 342 TYR A CB  1 
ATOM   2976 C CG  . TYR A 1 347 ? 24.39445  26.24923 35.93128 1.000 48.84700  ? 342 TYR A CG  1 
ATOM   2977 C CD1 . TYR A 1 347 ? 23.69077  26.80019 37.00245 1.000 45.12835  ? 342 TYR A CD1 1 
ATOM   2978 C CD2 . TYR A 1 347 ? 25.70901  26.64800 35.73212 1.000 45.93927  ? 342 TYR A CD2 1 
ATOM   2979 C CE1 . TYR A 1 347 ? 24.27501  27.74895 37.83730 1.000 43.49867  ? 342 TYR A CE1 1 
ATOM   2980 C CE2 . TYR A 1 347 ? 26.30711  27.58869 36.55588 1.000 45.40551  ? 342 TYR A CE2 1 
ATOM   2981 C CZ  . TYR A 1 347 ? 25.58279  28.13966 37.61224 1.000 50.86758  ? 342 TYR A CZ  1 
ATOM   2982 O OH  . TYR A 1 347 ? 26.16246  29.08135 38.45026 1.000 50.04463  ? 342 TYR A OH  1 
ATOM   2983 N N   . ASP A 1 348 ? 24.11573  26.25898 32.07964 1.000 38.78830  ? 343 ASP A N   1 
ATOM   2984 C CA  . ASP A 1 348 ? 24.74278  27.10312 31.05590 1.000 39.52919  ? 343 ASP A CA  1 
ATOM   2985 C C   . ASP A 1 348 ? 23.72663  27.99362 30.35276 1.000 37.13144  ? 343 ASP A C   1 
ATOM   2986 O O   . ASP A 1 348 ? 24.00720  29.16809 30.05095 1.000 38.21352  ? 343 ASP A O   1 
ATOM   2987 C CB  . ASP A 1 348 ? 25.45592  26.24086 30.00321 1.000 44.23106  ? 343 ASP A CB  1 
ATOM   2988 C CG  . ASP A 1 348 ? 26.75415  25.59567 30.51380 1.000 54.24806  ? 343 ASP A CG  1 
ATOM   2989 O OD1 . ASP A 1 348 ? 27.26059  25.97382 31.59305 1.000 53.90973  ? 343 ASP A OD1 1 
ATOM   2990 O OD2 . ASP A 1 348 ? 27.26940  24.69099 29.81773 1.000 58.69736  ? 343 ASP A OD2 1 
ATOM   2991 N N   . GLU A 1 349 ? 22.55490  27.44077 30.02843 1.000 38.91633  ? 344 GLU A N   1 
ATOM   2992 C CA  . GLU A 1 349 ? 21.52474  28.25561 29.38240 1.000 41.43064  ? 344 GLU A CA  1 
ATOM   2993 C C   . GLU A 1 349 ? 20.96276  29.31047 30.33914 1.000 40.16905  ? 344 GLU A C   1 
ATOM   2994 O O   . GLU A 1 349 ? 20.63570  30.42806 29.92143 1.000 40.04900  ? 344 GLU A O   1 
ATOM   2995 C CB  . GLU A 1 349 ? 20.40411  27.36059 28.83107 1.000 37.46976  ? 344 GLU A CB  1 
ATOM   2996 C CG  . GLU A 1 349 ? 20.86931  26.48875 27.64380 1.000 46.56618  ? 344 GLU A CG  1 
ATOM   2997 C CD  . GLU A 1 349 ? 21.05286  27.29577 26.37760 1.000 37.98331  ? 344 GLU A CD  1 
ATOM   2998 O OE1 . GLU A 1 349 ? 20.44932  28.38546 26.28878 1.000 42.51089  ? 344 GLU A OE1 1 
ATOM   2999 O OE2 . GLU A 1 349 ? 21.81712  26.86351 25.47199 1.000 42.17167  ? 344 GLU A OE2 1 
ATOM   3000 N N   . VAL A 1 350 ? 20.83565  28.97841 31.62320 1.000 38.21321  ? 345 VAL A N   1 
ATOM   3001 C CA  . VAL A 1 350 ? 20.38626  29.98052 32.59677 1.000 37.42897  ? 345 VAL A CA  1 
ATOM   3002 C C   . VAL A 1 350 ? 21.35506  31.15594 32.65730 1.000 41.40862  ? 345 VAL A C   1 
ATOM   3003 O O   . VAL A 1 350 ? 20.95189  32.31891 32.53821 1.000 42.97050  ? 345 VAL A O   1 
ATOM   3004 C CB  . VAL A 1 350 ? 20.19169  29.35090 33.98849 1.000 39.17397  ? 345 VAL A CB  1 
ATOM   3005 C CG1 . VAL A 1 350 ? 19.86525  30.46798 35.05107 1.000 36.69620  ? 345 VAL A CG1 1 
ATOM   3006 C CG2 . VAL A 1 350 ? 19.05525  28.32332 33.94205 1.000 37.17538  ? 345 VAL A CG2 1 
ATOM   3007 N N   . ILE A 1 351 ? 22.64850  30.88023 32.85729 1.000 40.02259  ? 346 ILE A N   1 
ATOM   3008 C CA  . ILE A 1 351 ? 23.57929  31.98537 33.07812 1.000 44.20970  ? 346 ILE A CA  1 
ATOM   3009 C C   . ILE A 1 351 ? 23.94628  32.70545 31.79267 1.000 40.88428  ? 346 ILE A C   1 
ATOM   3010 O O   . ILE A 1 351 ? 24.44952  33.83461 31.84717 1.000 44.97322  ? 346 ILE A O   1 
ATOM   3011 C CB  . ILE A 1 351 ? 24.80680  31.48904 33.87046 1.000 58.11204  ? 346 ILE A CB  1 
ATOM   3012 C CG1 . ILE A 1 351 ? 25.79071  30.73540 32.97130 1.000 48.58467  ? 346 ILE A CG1 1 
ATOM   3013 C CG2 . ILE A 1 351 ? 24.39311  30.67714 35.07737 1.000 53.69181  ? 346 ILE A CG2 1 
ATOM   3014 C CD1 . ILE A 1 351 ? 27.02353  30.26671 33.71496 1.000 60.85426  ? 346 ILE A CD1 1 
ATOM   3015 N N   . SER A 1 352 ? 23.63135  32.14039 30.64081 1.000 43.50347  ? 347 SER A N   1 
ATOM   3016 C CA  . SER A 1 352 ? 23.89587  32.86053 29.41017 1.000 40.44323  ? 347 SER A CA  1 
ATOM   3017 C C   . SER A 1 352 ? 22.71698  33.71093 28.94407 1.000 45.73216  ? 347 SER A C   1 
ATOM   3018 O O   . SER A 1 352 ? 22.83166  34.38216 27.91458 1.000 42.69372  ? 347 SER A O   1 
ATOM   3019 C CB  . SER A 1 352 ? 24.34211  31.87525 28.32212 1.000 50.35400  ? 347 SER A CB  1 
ATOM   3020 O OG  . SER A 1 352 ? 23.28302  31.03791 27.88066 1.000 46.53138  ? 347 SER A OG  1 
ATOM   3021 N N   . PHE A 1 353 ? 21.60912  33.74187 29.68704 1.000 39.39548  ? 348 PHE A N   1 
ATOM   3022 C CA  . PHE A 1 353 ? 20.41462  34.42822 29.20972 1.000 39.61665  ? 348 PHE A CA  1 
ATOM   3023 C C   . PHE A 1 353 ? 20.67743  35.91855 29.04822 1.000 49.05508  ? 348 PHE A C   1 
ATOM   3024 O O   . PHE A 1 353 ? 21.22830  36.55049 29.94241 1.000 38.29196  ? 348 PHE A O   1 
ATOM   3025 C CB  . PHE A 1 353 ? 19.23004  34.20212 30.17688 1.000 37.93176  ? 348 PHE A CB  1 
ATOM   3026 C CG  . PHE A 1 353 ? 17.98774  34.99719 29.79526 1.000 39.94476  ? 348 PHE A CG  1 
ATOM   3027 C CD1 . PHE A 1 353 ? 17.16729  34.58117 28.74277 1.000 41.98013  ? 348 PHE A CD1 1 
ATOM   3028 C CD2 . PHE A 1 353 ? 17.64389  36.14835 30.48997 1.000 41.88777  ? 348 PHE A CD2 1 
ATOM   3029 C CE1 . PHE A 1 353 ? 16.05204  35.31443 28.37117 1.000 35.48514  ? 348 PHE A CE1 1 
ATOM   3030 C CE2 . PHE A 1 353 ? 16.53831  36.88007 30.12694 1.000 43.94084  ? 348 PHE A CE2 1 
ATOM   3031 C CZ  . PHE A 1 353 ? 15.73449  36.46511 29.08182 1.000 39.25966  ? 348 PHE A CZ  1 
ATOM   3032 N N   . VAL A 1 354 ? 20.26059  36.48912 27.92455 1.000 42.80479  ? 349 VAL A N   1 
ATOM   3033 C CA  . VAL A 1 354 ? 20.35220  37.92922 27.71604 1.000 49.27271  ? 349 VAL A CA  1 
ATOM   3034 C C   . VAL A 1 354 ? 18.93468  38.48942 27.68745 1.000 45.61789  ? 349 VAL A C   1 
ATOM   3035 O O   . VAL A 1 354 ? 18.15416  38.11510 26.80943 1.000 41.67050  ? 349 VAL A O   1 
ATOM   3036 C CB  . VAL A 1 354 ? 21.09257  38.25979 26.41457 1.000 55.13107  ? 349 VAL A CB  1 
ATOM   3037 C CG1 . VAL A 1 354 ? 21.31817  39.74421 26.30923 1.000 52.96881  ? 349 VAL A CG1 1 
ATOM   3038 C CG2 . VAL A 1 354 ? 22.41727  37.49851 26.35669 1.000 63.60816  ? 349 VAL A CG2 1 
ATOM   3039 N N   . PRO A 1 355 ? 18.57519  39.39369 28.59031 1.000 50.35372  ? 350 PRO A N   1 
ATOM   3040 C CA  . PRO A 1 355 ? 17.23323  39.99323 28.57548 1.000 57.64325  ? 350 PRO A CA  1 
ATOM   3041 C C   . PRO A 1 355 ? 16.88593  40.54978 27.20648 1.000 51.00597  ? 350 PRO A C   1 
ATOM   3042 O O   . PRO A 1 355 ? 17.76840  40.99721 26.45998 1.000 51.57196  ? 350 PRO A O   1 
ATOM   3043 C CB  . PRO A 1 355 ? 17.34699  41.11934 29.61149 1.000 46.61763  ? 350 PRO A CB  1 
ATOM   3044 C CG  . PRO A 1 355 ? 18.49177  40.70969 30.48111 1.000 59.73640  ? 350 PRO A CG  1 
ATOM   3045 C CD  . PRO A 1 355 ? 19.44798  39.99487 29.61022 1.000 52.91500  ? 350 PRO A CD  1 
ATOM   3046 N N   . PRO A 1 356 ? 15.60887  40.54346 26.83281 1.000 51.26079  ? 351 PRO A N   1 
ATOM   3047 C CA  . PRO A 1 356 ? 15.22917  41.17302 25.57420 1.000 55.35908  ? 351 PRO A CA  1 
ATOM   3048 C C   . PRO A 1 356 ? 15.38777  42.67123 25.65848 1.000 73.60724  ? 351 PRO A C   1 
ATOM   3049 O O   . PRO A 1 356 ? 15.16325  43.28334 26.72171 1.000 72.81151  ? 351 PRO A O   1 
ATOM   3050 C CB  . PRO A 1 356 ? 13.75321  40.76448 25.40908 1.000 58.60378  ? 351 PRO A CB  1 
ATOM   3051 C CG  . PRO A 1 356 ? 13.25948  40.62127 26.81861 1.000 58.72611  ? 351 PRO A CG  1 
ATOM   3052 C CD  . PRO A 1 356 ? 14.43858  40.08966 27.61251 1.000 54.57167  ? 351 PRO A CD  1 
ATOM   3053 N N   . PRO A 1 357 ? 15.77374  43.33186 24.56258 1.000 75.52936  ? 352 PRO A N   1 
ATOM   3054 C CA  . PRO A 1 357 ? 15.86903  44.79597 24.58642 1.000 91.80665  ? 352 PRO A CA  1 
ATOM   3055 C C   . PRO A 1 357 ? 14.52518  45.48232 24.75306 1.000 91.22276  ? 352 PRO A C   1 
ATOM   3056 O O   . PRO A 1 357 ? 14.49196  46.71064 24.92190 1.000 97.86932  ? 352 PRO A O   1 
ATOM   3057 C CB  . PRO A 1 357 ? 16.51715  45.13824 23.23509 1.000 86.78911  ? 352 PRO A CB  1 
ATOM   3058 C CG  . PRO A 1 357 ? 16.53677  43.84935 22.42787 1.000 83.49302  ? 352 PRO A CG  1 
ATOM   3059 C CD  . PRO A 1 357 ? 15.82980  42.78450 23.19541 1.000 79.95116  ? 352 PRO A CD  1 
ATOM   3060 N N   . LEU A 1 358 ? 13.42997  44.72938 24.73723 1.000 91.88301  ? 353 LEU A N   1 
ATOM   3061 C CA  . LEU A 1 358 ? 12.09538  45.29986 24.82694 1.000 101.90984 ? 353 LEU A CA  1 
ATOM   3062 C C   . LEU A 1 358 ? 11.80394  45.77587 26.24681 1.000 91.77032  ? 353 LEU A C   1 
ATOM   3063 O O   . LEU A 1 358 ? 12.25277  46.84882 26.65448 1.000 98.40869  ? 353 LEU A O   1 
ATOM   3064 C CB  . LEU A 1 358 ? 11.04778  44.27540 24.38230 1.000 106.41299 ? 353 LEU A CB  1 
ATOM   3065 C CG  . LEU A 1 358 ? 11.32821  43.51737 23.07698 1.000 105.93877 ? 353 LEU A CG  1 
ATOM   3066 C CD1 . LEU A 1 358 ? 10.07416  42.78712 22.58681 1.000 90.43861  ? 353 LEU A CD1 1 
ATOM   3067 C CD2 . LEU A 1 358 ? 11.89255  44.43793 21.99648 1.000 102.08982 ? 353 LEU A CD2 1 
HETATM 3068 C C11 A B8Z B 2 .   ? -12.47217 49.42599 21.92208 0.500 124.11371 ? 401 B8Z A C11 1 
HETATM 3069 C C11 B B8Z B 2 .   ? -12.70087 49.48388 21.75753 0.500 123.98562 ? 401 B8Z A C11 1 
HETATM 3070 C C12 A B8Z B 2 .   ? -13.39626 50.00266 22.76716 0.500 123.29699 ? 401 B8Z A C12 1 
HETATM 3071 C C12 B B8Z B 2 .   ? -12.01647 50.53051 21.19304 0.500 122.78011 ? 401 B8Z A C12 1 
HETATM 3072 C C14 A B8Z B 2 .   ? -11.81695 51.63704 21.76885 0.500 121.55006 ? 401 B8Z A C14 1 
HETATM 3073 C C14 B B8Z B 2 .   ? -13.68872 51.26914 22.88188 0.500 117.81472 ? 401 B8Z A C14 1 
HETATM 3074 C C15 A B8Z B 2 .   ? -11.02368 52.92707 21.35155 0.500 116.34285 ? 401 B8Z A C15 1 
HETATM 3075 C C15 B B8Z B 2 .   ? -14.61044 52.11818 23.85073 0.500 101.75276 ? 401 B8Z A C15 1 
HETATM 3076 C C17 A B8Z B 2 .   ? -9.50962  52.59163 23.32776 0.500 112.95518 ? 401 B8Z A C17 1 
HETATM 3077 C C17 B B8Z B 2 .   ? -16.04652 52.53903 21.94993 0.500 108.51451 ? 401 B8Z A C17 1 
HETATM 3078 C C18 A B8Z B 2 .   ? -9.95387  52.52209 24.66478 0.500 103.90955 ? 401 B8Z A C18 1 
HETATM 3079 C C18 B B8Z B 2 .   ? -15.63863 53.13272 20.73917 0.500 109.55085 ? 401 B8Z A C18 1 
HETATM 3080 C C19 A B8Z B 2 .   ? -9.30671  51.71407 25.60074 0.500 105.85934 ? 401 B8Z A C19 1 
HETATM 3081 C C19 B B8Z B 2 .   ? -16.17310 52.72942 19.51543 0.500 104.16982 ? 401 B8Z A C19 1 
HETATM 3082 C C20 A B8Z B 2 .   ? -8.18980  50.96700 25.20686 0.500 107.64540 ? 401 B8Z A C20 1 
HETATM 3083 C C20 B B8Z B 2 .   ? -17.13140 51.71622 19.49119 0.500 98.78009  ? 401 B8Z A C20 1 
HETATM 3084 C C22 A B8Z B 2 .   ? -7.72900  51.02845 23.89121 0.500 105.15190 ? 401 B8Z A C22 1 
HETATM 3085 C C22 B B8Z B 2 .   ? -17.55365 51.10982 20.67476 0.500 101.92000 ? 401 B8Z A C22 1 
HETATM 3086 C C01 A B8Z B 2 .   ? -11.46063 39.48986 23.59391 0.500 109.32191 ? 401 B8Z A C01 1 
HETATM 3087 C C01 B B8Z B 2 .   ? -11.45442 39.48082 23.62878 0.500 109.31454 ? 401 B8Z A C01 1 
HETATM 3088 C C03 A B8Z B 2 .   ? -12.37734 40.69376 21.63280 0.500 110.30559 ? 401 B8Z A C03 1 
HETATM 3089 C C03 B B8Z B 2 .   ? -12.36020 40.68721 21.66093 0.500 110.31994 ? 401 B8Z A C03 1 
HETATM 3090 C C04 A B8Z B 2 .   ? -12.84509 41.88557 22.20994 0.500 108.85888 ? 401 B8Z A C04 1 
HETATM 3091 C C04 B B8Z B 2 .   ? -12.83737 41.87318 22.24359 0.500 108.84902 ? 401 B8Z A C04 1 
HETATM 3092 C C05 A B8Z B 2 .   ? -12.69040 43.12667 21.57429 0.500 114.62586 ? 401 B8Z A C05 1 
HETATM 3093 C C05 B B8Z B 2 .   ? -12.68921 43.11902 21.61688 0.500 114.61993 ? 401 B8Z A C05 1 
HETATM 3094 C C07 A B8Z B 2 .   ? -12.95425 45.42776 21.36574 0.500 121.26795 ? 401 B8Z A C07 1 
HETATM 3095 C C07 B B8Z B 2 .   ? -12.96712 45.42217 21.43404 0.500 121.26554 ? 401 B8Z A C07 1 
HETATM 3096 C C09 A B8Z B 2 .   ? -12.30636 47.90988 21.62649 0.500 122.06936 ? 401 B8Z A C09 1 
HETATM 3097 C C09 B B8Z B 2 .   ? -12.45481 47.97190 21.46091 0.500 121.97010 ? 401 B8Z A C09 1 
HETATM 3098 C C23 A B8Z B 2 .   ? -8.38704  51.83767 22.97285 0.500 107.51900 ? 401 B8Z A C23 1 
HETATM 3099 C C23 B B8Z B 2 .   ? -17.01018 51.52440 21.88783 0.500 106.76995 ? 401 B8Z A C23 1 
HETATM 3100 C C26 A B8Z B 2 .   ? -12.02923 43.17149 20.33228 0.500 113.67426 ? 401 B8Z A C26 1 
HETATM 3101 C C26 B B8Z B 2 .   ? -12.02422 43.17627 20.37701 0.500 113.70533 ? 401 B8Z A C26 1 
HETATM 3102 C C27 A B8Z B 2 .   ? -11.53424 41.99591 19.74026 0.500 110.34361 ? 401 B8Z A C27 1 
HETATM 3103 C C27 B B8Z B 2 .   ? -11.51909 42.00651 19.77837 0.500 110.34445 ? 401 B8Z A C27 1 
HETATM 3104 C C28 A B8Z B 2 .   ? -11.67713 40.74423 20.37410 0.500 108.57542 ? 401 B8Z A C28 1 
HETATM 3105 C C28 B B8Z B 2 .   ? -11.65537 40.74907 20.40421 0.500 108.57943 ? 401 B8Z A C28 1 
HETATM 3106 C C30 A B8Z B 2 .   ? -11.84724 39.21227 18.28995 0.500 96.16742  ? 401 B8Z A C30 1 
HETATM 3107 C C30 B B8Z B 2 .   ? -11.85190 39.20734 18.33103 0.500 96.17732  ? 401 B8Z A C30 1 
HETATM 3108 F F21 A B8Z B 2 .   ? -7.55944  50.19115 26.08616 0.500 107.03426 ? 401 B8Z A F21 1 
HETATM 3109 F F21 B B8Z B 2 .   ? -17.64769 51.32287 18.33431 0.500 101.43197 ? 401 B8Z A F21 1 
HETATM 3110 N N06 A B8Z B 2 .   ? -13.17548 44.37043 22.12972 0.500 119.11388 ? 401 B8Z A N06 1 
HETATM 3111 N N06 B B8Z B 2 .   ? -13.18574 44.35611 22.18174 0.500 119.12339 ? 401 B8Z A N06 1 
HETATM 3112 N N08 A B8Z B 2 .   ? -13.25757 46.82299 21.61360 0.500 119.62068 ? 401 B8Z A N08 1 
HETATM 3113 N N08 B B8Z B 2 .   ? -13.29340 46.81407 21.69741 0.500 119.59613 ? 401 B8Z A N08 1 
HETATM 3114 N N24 A B8Z B 2 .   ? -11.55573 50.39175 21.38426 0.500 123.53820 ? 401 B8Z A N24 1 
HETATM 3115 N N24 B B8Z B 2 .   ? -13.65437 49.93689 22.75600 0.500 123.16308 ? 401 B8Z A N24 1 
HETATM 3116 O O02 A B8Z B 2 .   ? -12.52413 39.47819 22.37811 0.500 111.24009 ? 401 B8Z A O02 1 
HETATM 3117 O O02 B B8Z B 2 .   ? -12.50421 39.46709 22.40033 0.500 111.24151 ? 401 B8Z A O02 1 
HETATM 3118 O O10 A B8Z B 2 .   ? -11.15278 47.58889 21.39146 0.500 123.04510 ? 401 B8Z A O10 1 
HETATM 3119 O O10 B B8Z B 2 .   ? -11.35580 47.73804 20.98671 0.500 122.74306 ? 401 B8Z A O10 1 
HETATM 3120 O O16 A B8Z B 2 .   ? -10.14927 53.40811 22.39825 0.500 115.57210 ? 401 B8Z A O16 1 
HETATM 3121 O O16 B B8Z B 2 .   ? -15.50865 52.94983 23.15501 0.500 101.12399 ? 401 B8Z A O16 1 
HETATM 3122 O O29 A B8Z B 2 .   ? -11.21581 39.54003 19.76754 0.500 102.29930 ? 401 B8Z A O29 1 
HETATM 3123 O O29 B B8Z B 2 .   ? -11.18750 39.54962 19.79108 0.500 102.29587 ? 401 B8Z A O29 1 
HETATM 3124 S S13 A B8Z B 2 .   ? -13.20844 51.71808 22.86915 0.500 118.85274 ? 401 B8Z A S13 1 
HETATM 3125 S S13 B B8Z B 2 .   ? -12.53171 52.06139 21.79997 0.500 122.80381 ? 401 B8Z A S13 1 
HETATM 3126 S S25 A B8Z B 2 .   ? -12.01108 44.87523 19.82571 0.500 121.72387 ? 401 B8Z A S25 1 
HETATM 3127 S S25 B B8Z B 2 .   ? -12.01673 44.88539 19.88308 0.500 121.73349 ? 401 B8Z A S25 1 
HETATM 3128 H H1  A B8Z B 2 .   ? -14.19039 49.54714 23.35132 0.500 148.01617 ? 401 B8Z A H1  1 
HETATM 3129 H H1  B B8Z B 2 .   ? -11.22720 50.52739 20.44710 0.500 147.39592 ? 401 B8Z A H1  1 
HETATM 3130 H H2  A B8Z B 2 .   ? -11.73798 53.73504 21.06838 0.500 139.67120 ? 401 B8Z A H2  1 
HETATM 3131 H H2  B B8Z B 2 .   ? -13.97773 52.74176 24.52456 0.500 122.16310 ? 401 B8Z A H2  1 
HETATM 3132 H H3  A B8Z B 2 .   ? -10.42249 52.72134 20.43532 0.500 139.67120 ? 401 B8Z A H3  1 
HETATM 3133 H H3  B B8Z B 2 .   ? -15.18381 51.43630 24.52118 0.500 122.16310 ? 401 B8Z A H3  1 
HETATM 3134 H H4  A B8Z B 2 .   ? -10.81432 53.09296 25.01692 0.500 124.75125 ? 401 B8Z A H4  1 
HETATM 3135 H H4  B B8Z B 2 .   ? -14.89199 53.92772 20.71129 0.500 131.52080 ? 401 B8Z A H4  1 
HETATM 3136 H H5  A B8Z B 2 .   ? -9.64079  51.63999 26.64195 0.500 127.09099 ? 401 B8Z A H5  1 
HETATM 3137 H H5  B B8Z B 2 .   ? -15.86781 53.18039 18.56431 0.500 125.06357 ? 401 B8Z A H5  1 
HETATM 3138 H H6  A B8Z B 2 .   ? -6.85311  50.43132 23.61684 0.500 126.24207 ? 401 B8Z A H6  1 
HETATM 3139 H H6  B B8Z B 2 .   ? -18.30742 50.31776 20.61560 0.500 122.36378 ? 401 B8Z A H6  1 
HETATM 3140 H H7  A B8Z B 2 .   ? -11.20949 40.48437 23.98847 0.500 131.24608 ? 401 B8Z A H7  1 
HETATM 3141 H H7  B B8Z B 2 .   ? -11.20018 40.47665 24.01798 0.500 131.23724 ? 401 B8Z A H7  1 
HETATM 3142 H H8  A B8Z B 2 .   ? -10.47677 39.05896 23.36120 0.500 131.24608 ? 401 B8Z A H8  1 
HETATM 3143 H H8  B B8Z B 2 .   ? -10.47130 39.04047 23.41115 0.500 131.23724 ? 401 B8Z A H8  1 
HETATM 3144 H H9  A B8Z B 2 .   ? -11.76832 38.93641 24.49214 0.500 131.24608 ? 401 B8Z A H9  1 
HETATM 3145 H H9  B B8Z B 2 .   ? -11.77678 38.93730 24.52793 0.500 131.23724 ? 401 B8Z A H9  1 
HETATM 3146 H H10 A B8Z B 2 .   ? -13.34162 41.84323 23.17823 0.500 130.69044 ? 401 B8Z A H10 1 
HETATM 3147 H H10 B B8Z B 2 .   ? -13.33655 41.82163 23.21007 0.500 130.67860 ? 401 B8Z A H10 1 
HETATM 3148 H H11 A B8Z B 2 .   ? -7.99098  51.86149 21.95871 0.500 129.08258 ? 401 B8Z A H11 1 
HETATM 3149 H H11 B B8Z B 2 .   ? -17.36507 51.02705 22.78928 0.500 128.18372 ? 401 B8Z A H11 1 
HETATM 3150 H H13 A B8Z B 2 .   ? -12.47899 39.99059 17.84439 0.500 115.46069 ? 401 B8Z A H13 1 
HETATM 3151 H H13 B B8Z B 2 .   ? -12.49196 39.98211 17.89117 0.500 115.47256 ? 401 B8Z A H13 1 
HETATM 3152 H H14 A B8Z B 2 .   ? -12.49830 38.33209 18.22053 0.500 115.46069 ? 401 B8Z A H14 1 
HETATM 3153 H H14 B B8Z B 2 .   ? -12.50583 38.32774 18.28530 0.500 115.47256 ? 401 B8Z A H14 1 
HETATM 3154 H H15 A B8Z B 2 .   ? -11.12943 39.02085 17.48278 0.500 115.46069 ? 401 B8Z A H15 1 
HETATM 3155 H H15 B B8Z B 2 .   ? -11.15232 39.00597 17.51039 0.500 115.47256 ? 401 B8Z A H15 1 
HETATM 3156 H H16 A B8Z B 2 .   ? -14.23522 47.03808 21.79307 0.500 143.60460 ? 401 B8Z A H16 1 
HETATM 3157 H H16 B B8Z B 2 .   ? -14.21721 46.97404 22.09145 0.500 143.57514 ? 401 B8Z A H16 1 
HETATM 3158 O O   . HOH C 3 .   ? 8.57637   33.08905 10.97931 1.000 64.01484  ? 501 HOH A O   1 
HETATM 3159 O O   . HOH C 3 .   ? -0.34908  27.98249 24.63355 1.000 73.78842  ? 502 HOH A O   1 
HETATM 3160 O O   . HOH C 3 .   ? 16.05225  39.76702 22.56561 1.000 81.12705  ? 503 HOH A O   1 
HETATM 3161 O O   . HOH C 3 .   ? -16.29398 21.78352 1.40952  1.000 68.76618  ? 504 HOH A O   1 
HETATM 3162 O O   . HOH C 3 .   ? -13.47947 27.35109 23.29216 1.000 61.88034  ? 505 HOH A O   1 
HETATM 3163 O O   . HOH C 3 .   ? 2.57136   19.78540 21.74752 1.000 64.64030  ? 506 HOH A O   1 
HETATM 3164 O O   . HOH C 3 .   ? 11.00675  20.96118 34.17342 1.000 60.32887  ? 507 HOH A O   1 
HETATM 3165 O O   . HOH C 3 .   ? -11.65999 45.67151 9.33501  1.000 70.10729  ? 508 HOH A O   1 
HETATM 3166 O O   . HOH C 3 .   ? -11.07089 25.16214 -0.43249 1.000 54.22052  ? 509 HOH A O   1 
HETATM 3167 O O   . HOH C 3 .   ? -18.03933 32.88816 20.62445 1.000 85.86330  ? 510 HOH A O   1 
HETATM 3168 O O   . HOH C 3 .   ? -5.73073  19.68894 9.25685  1.000 68.91299  ? 511 HOH A O   1 
HETATM 3169 O O   . HOH C 3 .   ? -5.44724  29.51096 29.34887 1.000 51.81095  ? 512 HOH A O   1 
HETATM 3170 O O   . HOH C 3 .   ? 25.50108  19.67489 43.57058 1.000 74.71257  ? 513 HOH A O   1 
HETATM 3171 O O   . HOH C 3 .   ? -13.58194 5.07308  21.92018 1.000 68.73707  ? 514 HOH A O   1 
HETATM 3172 O O   . HOH C 3 .   ? 9.14278   23.70455 8.86293  1.000 37.20843  ? 515 HOH A O   1 
HETATM 3173 O O   . HOH C 3 .   ? -13.66858 43.26203 6.38061  1.000 79.63729  ? 516 HOH A O   1 
HETATM 3174 O O   . HOH C 3 .   ? 26.13601  10.56526 29.14914 1.000 70.03082  ? 517 HOH A O   1 
HETATM 3175 O O   . HOH C 3 .   ? 7.30498   19.38136 37.31249 1.000 76.78866  ? 518 HOH A O   1 
HETATM 3176 O O   . HOH C 3 .   ? 14.36715  28.59815 45.04038 1.000 46.91029  ? 519 HOH A O   1 
HETATM 3177 O O   . HOH C 3 .   ? -10.78559 41.60780 8.50977  1.000 73.28678  ? 520 HOH A O   1 
HETATM 3178 O O   . HOH C 3 .   ? 11.06763  36.00272 47.59031 1.000 57.07303  ? 521 HOH A O   1 
HETATM 3179 O O   . HOH C 3 .   ? -20.03908 7.55925  19.31902 1.000 49.19307  ? 522 HOH A O   1 
HETATM 3180 O O   . HOH C 3 .   ? 26.51688  24.04800 27.66217 1.000 64.37760  ? 523 HOH A O   1 
HETATM 3181 O O   . HOH C 3 .   ? 22.87436  24.25992 25.65218 1.000 38.80055  ? 524 HOH A O   1 
HETATM 3182 O O   . HOH C 3 .   ? -18.71963 5.33108  8.15998  1.000 57.85517  ? 525 HOH A O   1 
HETATM 3183 O O   . HOH C 3 .   ? 23.99116  21.16405 20.89509 1.000 59.85139  ? 526 HOH A O   1 
HETATM 3184 O O   . HOH C 3 .   ? 29.54179  11.73169 29.43636 1.000 47.30536  ? 527 HOH A O   1 
HETATM 3185 O O   . HOH C 3 .   ? -15.19442 26.00998 -1.30884 1.000 68.73283  ? 528 HOH A O   1 
HETATM 3186 O O   . HOH C 3 .   ? 6.56126   42.36340 46.98490 1.000 54.87452  ? 529 HOH A O   1 
HETATM 3187 O O   . HOH C 3 .   ? -20.10810 31.67410 11.46823 1.000 66.39893  ? 530 HOH A O   1 
HETATM 3188 O O   . HOH C 3 .   ? -18.34054 17.23808 14.70353 1.000 51.32184  ? 531 HOH A O   1 
HETATM 3189 O O   . HOH C 3 .   ? 24.88473  21.04465 18.08108 1.000 48.18389  ? 532 HOH A O   1 
HETATM 3190 O O   . HOH C 3 .   ? 0.55926   9.56239  -2.50347 1.000 62.02350  ? 533 HOH A O   1 
HETATM 3191 O O   . HOH C 3 .   ? -3.95037  18.84517 25.30734 1.000 54.06920  ? 534 HOH A O   1 
HETATM 3192 O O   . HOH C 3 .   ? 1.06488   36.99245 -0.44592 1.000 63.19404  ? 535 HOH A O   1 
HETATM 3193 O O   . HOH C 3 .   ? -1.33126  -9.44127 10.03711 1.000 76.02942  ? 536 HOH A O   1 
HETATM 3194 O O   . HOH C 3 .   ? 15.97689  29.14853 47.18166 1.000 62.39592  ? 537 HOH A O   1 
HETATM 3195 O O   . HOH C 3 .   ? -20.68772 12.16371 20.25323 1.000 62.02839  ? 538 HOH A O   1 
HETATM 3196 O O   . HOH C 3 .   ? 1.49964   41.48360 9.37912  1.000 54.25752  ? 539 HOH A O   1 
HETATM 3197 O O   . HOH C 3 .   ? 18.19795  28.52849 20.02234 1.000 49.29974  ? 540 HOH A O   1 
HETATM 3198 O O   . HOH C 3 .   ? -17.97743 22.56449 0.77258  1.000 56.47640  ? 541 HOH A O   1 
HETATM 3199 O O   . HOH C 3 .   ? 7.29564   12.71646 24.64960 1.000 86.41245  ? 542 HOH A O   1 
HETATM 3200 O O   . HOH C 3 .   ? 6.79538   36.67315 27.93760 1.000 58.36596  ? 543 HOH A O   1 
HETATM 3201 O O   . HOH C 3 .   ? -18.45004 20.73048 23.64743 1.000 55.93416  ? 544 HOH A O   1 
HETATM 3202 O O   . HOH C 3 .   ? -11.03073 19.43499 2.14849  1.000 57.43890  ? 545 HOH A O   1 
HETATM 3203 O O   . HOH C 3 .   ? 14.88143  22.74285 14.64960 1.000 49.59344  ? 546 HOH A O   1 
HETATM 3204 O O   . HOH C 3 .   ? 25.55190  19.23780 36.33585 1.000 54.80259  ? 547 HOH A O   1 
HETATM 3205 O O   . HOH C 3 .   ? 16.34734  37.19595 25.24642 1.000 53.58217  ? 548 HOH A O   1 
HETATM 3206 O O   . HOH C 3 .   ? 3.18051   7.49126  6.27271  1.000 60.62838  ? 549 HOH A O   1 
HETATM 3207 O O   . HOH C 3 .   ? 8.89735   14.69659 28.91851 1.000 69.47977  ? 550 HOH A O   1 
HETATM 3208 O O   . HOH C 3 .   ? -2.31686  30.21961 -0.34523 1.000 50.68245  ? 551 HOH A O   1 
HETATM 3209 O O   . HOH C 3 .   ? -17.40289 -3.36065 8.58695  1.000 78.15922  ? 552 HOH A O   1 
HETATM 3210 O O   . HOH C 3 .   ? -17.99577 14.82180 -1.17893 1.000 48.20803  ? 553 HOH A O   1 
HETATM 3211 O O   . HOH C 3 .   ? -4.61069  11.36623 -0.14783 1.000 58.69214  ? 554 HOH A O   1 
HETATM 3212 O O   . HOH C 3 .   ? 27.80435  22.19832 30.21581 1.000 50.62231  ? 555 HOH A O   1 
HETATM 3213 O O   . HOH C 3 .   ? 1.11125   21.97519 26.07504 1.000 50.99041  ? 556 HOH A O   1 
HETATM 3214 O O   . HOH C 3 .   ? 4.42914   35.08265 4.48783  1.000 49.02728  ? 557 HOH A O   1 
HETATM 3215 O O   . HOH C 3 .   ? -2.52549  18.88701 18.75606 1.000 55.30917  ? 558 HOH A O   1 
HETATM 3216 O O   . HOH C 3 .   ? -19.20459 2.54258  9.40880  1.000 64.27542  ? 559 HOH A O   1 
HETATM 3217 O O   . HOH C 3 .   ? 12.87010  24.85079 40.34754 1.000 50.43993  ? 560 HOH A O   1 
HETATM 3218 O O   . HOH C 3 .   ? -15.94301 36.89251 1.02624  1.000 58.80872  ? 561 HOH A O   1 
HETATM 3219 O O   . HOH C 3 .   ? 2.84397   15.44603 6.01725  1.000 56.16330  ? 562 HOH A O   1 
HETATM 3220 O O   . HOH C 3 .   ? 10.52946  25.21589 49.56232 1.000 84.16382  ? 563 HOH A O   1 
HETATM 3221 O O   . HOH C 3 .   ? 21.49241  32.64668 25.45305 1.000 60.64246  ? 564 HOH A O   1 
HETATM 3222 O O   . HOH C 3 .   ? 17.31242  47.99471 41.79546 1.000 46.19801  ? 565 HOH A O   1 
HETATM 3223 O O   . HOH C 3 .   ? 6.96995   46.17918 47.50222 1.000 47.30266  ? 566 HOH A O   1 
HETATM 3224 O O   . HOH C 3 .   ? -9.89602  12.19456 30.98808 1.000 61.37238  ? 567 HOH A O   1 
HETATM 3225 O O   . HOH C 3 .   ? -25.66752 29.23661 23.65363 1.000 48.18305  ? 568 HOH A O   1 
HETATM 3226 O O   . HOH C 3 .   ? 23.76358  12.11018 36.83903 1.000 55.71909  ? 569 HOH A O   1 
HETATM 3227 O O   . HOH C 3 .   ? 3.25237   25.26525 8.40023  1.000 37.71542  ? 570 HOH A O   1 
HETATM 3228 O O   . HOH C 3 .   ? 10.01117  18.73029 16.29756 1.000 65.46904  ? 571 HOH A O   1 
HETATM 3229 O O   . HOH C 3 .   ? 20.70662  8.85854  29.55048 1.000 59.96893  ? 572 HOH A O   1 
HETATM 3230 O O   . HOH C 3 .   ? -15.18329 15.30634 30.49389 1.000 49.15251  ? 573 HOH A O   1 
HETATM 3231 O O   . HOH C 3 .   ? -4.37472  20.39790 20.22718 1.000 42.66080  ? 574 HOH A O   1 
HETATM 3232 O O   . HOH C 3 .   ? 12.34054  34.40934 24.07178 1.000 39.08133  ? 575 HOH A O   1 
HETATM 3233 O O   . HOH C 3 .   ? -7.84929  16.03274 30.48912 1.000 65.34553  ? 576 HOH A O   1 
HETATM 3234 O O   . HOH C 3 .   ? -2.66869  8.18542  31.93364 1.000 68.07177  ? 577 HOH A O   1 
HETATM 3235 O O   . HOH C 3 .   ? -12.39602 19.66843 28.41836 1.000 49.87582  ? 578 HOH A O   1 
HETATM 3236 O O   . HOH C 3 .   ? -15.45375 23.16022 -2.48015 1.000 49.83924  ? 579 HOH A O   1 
HETATM 3237 O O   . HOH C 3 .   ? 3.22074   42.12254 30.32272 1.000 58.02205  ? 580 HOH A O   1 
HETATM 3238 O O   . HOH C 3 .   ? 15.57697  13.32385 17.47813 1.000 74.17356  ? 581 HOH A O   1 
HETATM 3239 O O   . HOH C 3 .   ? 11.39010  40.57616 33.56635 1.000 48.42540  ? 582 HOH A O   1 
HETATM 3240 O O   . HOH C 3 .   ? 1.81159   25.55209 53.73034 1.000 80.35440  ? 583 HOH A O   1 
HETATM 3241 O O   . HOH C 3 .   ? 17.47586  39.87434 50.73435 1.000 57.81509  ? 584 HOH A O   1 
HETATM 3242 O O   . HOH C 3 .   ? 18.35262  44.56230 49.37555 1.000 54.23411  ? 585 HOH A O   1 
HETATM 3243 O O   . HOH C 3 .   ? 20.30033  30.29653 15.50534 1.000 46.51730  ? 586 HOH A O   1 
HETATM 3244 O O   . HOH C 3 .   ? -22.80286 15.18626 15.36662 1.000 56.06845  ? 587 HOH A O   1 
HETATM 3245 O O   . HOH C 3 .   ? 17.59473  15.37898 16.65378 1.000 53.71623  ? 588 HOH A O   1 
HETATM 3246 O O   . HOH C 3 .   ? 20.95841  44.44993 48.26640 1.000 60.52487  ? 589 HOH A O   1 
HETATM 3247 O O   . HOH C 3 .   ? -22.44482 28.90442 3.85603  1.000 59.89326  ? 590 HOH A O   1 
HETATM 3248 O O   . HOH C 3 .   ? 15.05355  18.30220 40.62839 1.000 59.98996  ? 591 HOH A O   1 
HETATM 3249 O O   . HOH C 3 .   ? 24.66090  20.38114 40.92077 1.000 73.09716  ? 592 HOH A O   1 
HETATM 3250 O O   . HOH C 3 .   ? 19.93356  26.74920 17.76227 1.000 42.40924  ? 593 HOH A O   1 
HETATM 3251 O O   . HOH C 3 .   ? -5.21514  21.84311 1.27319  1.000 39.16456  ? 594 HOH A O   1 
HETATM 3252 O O   . HOH C 3 .   ? -20.27221 12.49800 5.13174  1.000 46.08789  ? 595 HOH A O   1 
HETATM 3253 O O   . HOH C 3 .   ? 14.28004  33.60076 15.72905 1.000 44.86061  ? 596 HOH A O   1 
HETATM 3254 O O   . HOH C 3 .   ? -9.13267  40.24878 4.88227  1.000 61.17033  ? 597 HOH A O   1 
HETATM 3255 O O   . HOH C 3 .   ? -17.52660 34.36139 8.47271  1.000 48.59670  ? 598 HOH A O   1 
HETATM 3256 O O   . HOH C 3 .   ? 10.952    51.376   37.916   1.000 43.49746  ? 599 HOH A O   1 
HETATM 3257 O O   . HOH C 3 .   ? 7.02259   28.20766 8.17053  1.000 35.62662  ? 600 HOH A O   1 
HETATM 3258 O O   . HOH C 3 .   ? -13.41631 6.20996  1.58817  1.000 53.90116  ? 601 HOH A O   1 
HETATM 3259 O O   . HOH C 3 .   ? 9.03632   20.39585 17.82384 1.000 55.77364  ? 602 HOH A O   1 
HETATM 3260 O O   . HOH C 3 .   ? 19.28220  18.14794 41.51226 1.000 64.08113  ? 603 HOH A O   1 
HETATM 3261 O O   . HOH C 3 .   ? 8.37822   38.85766 6.27471  1.000 48.51734  ? 604 HOH A O   1 
HETATM 3262 O O   . HOH C 3 .   ? 22.21360  33.47558 41.19108 1.000 51.84549  ? 605 HOH A O   1 
HETATM 3263 O O   . HOH C 3 .   ? -17.78341 24.44029 14.98644 1.000 43.84842  ? 606 HOH A O   1 
HETATM 3264 O O   . HOH C 3 .   ? 21.67254  10.20460 35.40280 1.000 55.88752  ? 607 HOH A O   1 
HETATM 3265 O O   . HOH C 3 .   ? -20.57987 30.32070 2.88457  1.000 53.17887  ? 608 HOH A O   1 
HETATM 3266 O O   . HOH C 3 .   ? -9.83025  14.77418 3.82341  1.000 38.99478  ? 609 HOH A O   1 
HETATM 3267 O O   . HOH C 3 .   ? 15.82416  33.08278 18.04285 1.000 44.60894  ? 610 HOH A O   1 
HETATM 3268 O O   . HOH C 3 .   ? 24.69402  31.26427 39.17542 1.000 49.69012  ? 611 HOH A O   1 
HETATM 3269 O O   . HOH C 3 .   ? 5.24522   6.56563  10.00248 1.000 61.46271  ? 612 HOH A O   1 
HETATM 3270 O O   . HOH C 3 .   ? -19.00778 15.95419 12.26494 1.000 38.13550  ? 613 HOH A O   1 
HETATM 3271 O O   . HOH C 3 .   ? -19.88227 14.24907 20.37217 1.000 54.51675  ? 614 HOH A O   1 
HETATM 3272 O O   . HOH C 3 .   ? 10.69297  18.61896 34.13051 1.000 59.68580  ? 615 HOH A O   1 
HETATM 3273 O O   . HOH C 3 .   ? -13.42576 38.25390 3.08783  1.000 55.09354  ? 616 HOH A O   1 
HETATM 3274 O O   . HOH C 3 .   ? -6.85618  19.03384 21.69111 1.000 37.87496  ? 617 HOH A O   1 
HETATM 3275 O O   . HOH C 3 .   ? 6.40646   39.48370 46.90991 1.000 53.04379  ? 618 HOH A O   1 
HETATM 3276 O O   . HOH C 3 .   ? 0.80086   39.75804 20.12579 1.000 50.07546  ? 619 HOH A O   1 
HETATM 3277 O O   . HOH C 3 .   ? 6.53225   29.51888 31.24638 1.000 63.79393  ? 620 HOH A O   1 
HETATM 3278 O O   . HOH C 3 .   ? -14.94911 40.27620 7.46274  1.000 72.16928  ? 621 HOH A O   1 
HETATM 3279 O O   . HOH C 3 .   ? 27.56031  24.00947 33.50725 1.000 58.08508  ? 622 HOH A O   1 
HETATM 3280 O O   . HOH C 3 .   ? 8.35100   37.46907 24.84076 1.000 73.99410  ? 623 HOH A O   1 
HETATM 3281 O O   . HOH C 3 .   ? -11.84942 18.61402 3.76705  1.000 50.41459  ? 624 HOH A O   1 
HETATM 3282 O O   . HOH C 3 .   ? -18.14412 5.50727  18.53796 1.000 51.39479  ? 625 HOH A O   1 
HETATM 3283 O O   . HOH C 3 .   ? 8.55492   35.72937 21.45546 1.000 40.81258  ? 626 HOH A O   1 
HETATM 3284 O O   . HOH C 3 .   ? 3.60240   29.68996 27.90643 1.000 60.30908  ? 627 HOH A O   1 
HETATM 3285 O O   . HOH C 3 .   ? 12.88582  20.71898 20.96022 1.000 46.02758  ? 628 HOH A O   1 
HETATM 3286 O O   . HOH C 3 .   ? 22.71435  21.00864 23.36516 1.000 42.16980  ? 629 HOH A O   1 
HETATM 3287 O O   . HOH C 3 .   ? -11.86991 24.91220 24.24715 1.000 46.65433  ? 630 HOH A O   1 
HETATM 3288 O O   . HOH C 3 .   ? -19.44080 20.07659 14.21889 1.000 49.19498  ? 631 HOH A O   1 
HETATM 3289 O O   . HOH C 3 .   ? 9.59661   20.50808 36.04082 1.000 54.96282  ? 632 HOH A O   1 
HETATM 3290 O O   . HOH C 3 .   ? 17.58364  28.02285 22.39573 1.000 38.11115  ? 633 HOH A O   1 
HETATM 3291 O O   . HOH C 3 .   ? -1.31366  21.58495 17.59831 1.000 32.28319  ? 634 HOH A O   1 
HETATM 3292 O O   . HOH C 3 .   ? 18.07019  8.84195  26.45398 1.000 71.87537  ? 635 HOH A O   1 
HETATM 3293 O O   . HOH C 3 .   ? 16.80444  38.72543 37.39858 1.000 48.80355  ? 636 HOH A O   1 
HETATM 3294 O O   . HOH C 3 .   ? 19.44456  43.19716 26.82194 1.000 54.00270  ? 637 HOH A O   1 
HETATM 3295 O O   . HOH C 3 .   ? 7.02181   39.55362 15.26292 1.000 48.05994  ? 638 HOH A O   1 
HETATM 3296 O O   . HOH C 3 .   ? -2.23077  12.34886 7.45231  1.000 51.28013  ? 639 HOH A O   1 
HETATM 3297 O O   . HOH C 3 .   ? 16.31373  9.16069  35.70622 1.000 51.51864  ? 640 HOH A O   1 
HETATM 3298 O O   . HOH C 3 .   ? 13.94657  36.18782 25.28790 1.000 44.58559  ? 641 HOH A O   1 
HETATM 3299 O O   . HOH C 3 .   ? 0.89495   19.86626 4.43741  1.000 38.62557  ? 642 HOH A O   1 
HETATM 3300 O O   . HOH C 3 .   ? 0.28522   21.66811 6.68165  1.000 37.56157  ? 643 HOH A O   1 
HETATM 3301 O O   . HOH C 3 .   ? 5.51154   6.49587  15.29653 1.000 86.86520  ? 644 HOH A O   1 
HETATM 3302 O O   . HOH C 3 .   ? 12.33339  36.84028 13.16491 1.000 40.95458  ? 645 HOH A O   1 
HETATM 3303 O O   . HOH C 3 .   ? 5.69890   35.33087 10.99017 1.000 38.57518  ? 646 HOH A O   1 
HETATM 3304 O O   . HOH C 3 .   ? -21.95108 7.13200  3.75806  1.000 62.48576  ? 647 HOH A O   1 
HETATM 3305 O O   . HOH C 3 .   ? 12.38272  13.22318 25.42162 1.000 66.71389  ? 648 HOH A O   1 
HETATM 3306 O O   . HOH C 3 .   ? -3.51943  37.13568 2.19229  1.000 38.90494  ? 649 HOH A O   1 
HETATM 3307 O O   . HOH C 3 .   ? 10.18395  37.51060 14.65022 1.000 40.86344  ? 650 HOH A O   1 
HETATM 3308 O O   . HOH C 3 .   ? 27.73313  36.46323 44.36489 1.000 73.19722  ? 651 HOH A O   1 
HETATM 3309 O O   . HOH C 3 .   ? 20.43832  34.39957 34.36026 1.000 59.92469  ? 652 HOH A O   1 
HETATM 3310 O O   . HOH C 3 .   ? 0.46542   33.06512 49.75545 1.000 76.33273  ? 653 HOH A O   1 
HETATM 3311 O O   . HOH C 3 .   ? 17.84579  32.79153 21.60747 1.000 65.33621  ? 654 HOH A O   1 
HETATM 3312 O O   . HOH C 3 .   ? 6.31137   26.72827 28.42724 1.000 58.39844  ? 655 HOH A O   1 
HETATM 3313 O O   . HOH C 3 .   ? -13.13322 3.95091  -2.16672 1.000 63.30084  ? 656 HOH A O   1 
HETATM 3314 O O   . HOH C 3 .   ? -16.15294 28.72507 -0.50147 1.000 52.98339  ? 657 HOH A O   1 
HETATM 3315 O O   . HOH C 3 .   ? -18.79080 8.82256  10.83777 1.000 60.60033  ? 658 HOH A O   1 
HETATM 3316 O O   . HOH C 3 .   ? 18.83911  32.95478 17.50369 1.000 62.37759  ? 659 HOH A O   1 
HETATM 3317 O O   . HOH C 3 .   ? 17.50604  41.30630 37.25480 1.000 52.77643  ? 660 HOH A O   1 
HETATM 3318 O O   . HOH C 3 .   ? 20.78870  37.78857 47.53231 1.000 47.62678  ? 661 HOH A O   1 
HETATM 3319 O O   . HOH C 3 .   ? 12.87833  41.30651 30.95049 1.000 56.75916  ? 662 HOH A O   1 
HETATM 3320 O O   . HOH C 3 .   ? 20.91602  21.34859 20.59402 1.000 41.19661  ? 663 HOH A O   1 
HETATM 3321 O O   . HOH C 3 .   ? -11.76359 16.00135 2.63451  1.000 52.71354  ? 664 HOH A O   1 
HETATM 3322 O O   . HOH C 3 .   ? 12.61192  24.56821 46.79616 1.000 70.75248  ? 665 HOH A O   1 
HETATM 3323 O O   . HOH C 3 .   ? -13.18694 23.18270 17.65129 1.000 31.63090  ? 666 HOH A O   1 
HETATM 3324 O O   . HOH C 3 .   ? -6.29015  47.08511 27.84305 1.000 80.93664  ? 667 HOH A O   1 
HETATM 3325 O O   . HOH C 3 .   ? 6.15708   38.10978 22.31052 1.000 59.51842  ? 668 HOH A O   1 
HETATM 3326 O O   . HOH C 3 .   ? 7.04594   23.56939 33.24157 1.000 61.47999  ? 669 HOH A O   1 
HETATM 3327 O O   . HOH C 3 .   ? -12.73722 20.37843 17.47766 1.000 29.70480  ? 670 HOH A O   1 
HETATM 3328 O O   . HOH C 3 .   ? 1.08134   36.94375 48.45998 1.000 68.44539  ? 671 HOH A O   1 
HETATM 3329 O O   . HOH C 3 .   ? -23.03196 17.83630 2.75806  1.000 42.97378  ? 672 HOH A O   1 
HETATM 3330 O O   . HOH C 3 .   ? -1.60306  38.97563 23.62860 1.000 55.17280  ? 673 HOH A O   1 
HETATM 3331 O O   . HOH C 3 .   ? 16.19905  24.97035 12.62853 1.000 61.35950  ? 674 HOH A O   1 
HETATM 3332 O O   . HOH C 3 .   ? -18.62005 1.31928  2.47313  1.000 50.05184  ? 675 HOH A O   1 
HETATM 3333 O O   . HOH C 3 .   ? -9.73876  17.06199 15.98150 1.000 32.16278  ? 676 HOH A O   1 
HETATM 3334 O O   . HOH C 3 .   ? 17.09641  11.08511 25.56487 1.000 71.06619  ? 677 HOH A O   1 
HETATM 3335 O O   . HOH C 3 .   ? 6.03623   46.05164 6.15351  1.000 69.98264  ? 678 HOH A O   1 
HETATM 3336 O O   . HOH C 3 .   ? 5.08466   26.02120 2.72478  1.000 44.69851  ? 679 HOH A O   1 
HETATM 3337 O O   . HOH C 3 .   ? -11.60406 3.73154  3.75760  1.000 60.85440  ? 680 HOH A O   1 
HETATM 3338 O O   . HOH C 3 .   ? -16.98662 10.08256 27.68390 1.000 54.11505  ? 681 HOH A O   1 
HETATM 3339 O O   . HOH C 3 .   ? 24.21215  15.91931 18.90841 1.000 43.53690  ? 682 HOH A O   1 
HETATM 3340 O O   . HOH C 3 .   ? 7.14953   21.94890 21.54297 1.000 63.54573  ? 683 HOH A O   1 
HETATM 3341 O O   . HOH C 3 .   ? 10.83890  42.57128 5.44572  1.000 71.69368  ? 684 HOH A O   1 
HETATM 3342 O O   . HOH C 3 .   ? 2.62428   17.40527 23.67506 1.000 77.73013  ? 685 HOH A O   1 
HETATM 3343 O O   . HOH C 3 .   ? -14.31061 10.03978 1.19599  1.000 61.56856  ? 686 HOH A O   1 
HETATM 3344 O O   . HOH C 3 .   ? 15.00622  8.99149  33.73993 1.000 65.29589  ? 687 HOH A O   1 
HETATM 3345 O O   . HOH C 3 .   ? 18.95618  43.52773 43.25693 1.000 49.08614  ? 688 HOH A O   1 
HETATM 3346 O O   . HOH C 3 .   ? 18.24849  20.87325 14.48723 1.000 57.45842  ? 689 HOH A O   1 
HETATM 3347 O O   . HOH C 3 .   ? -6.61166  9.20559  0.24287  1.000 42.45461  ? 690 HOH A O   1 
HETATM 3348 O O   . HOH C 3 .   ? 6.63521   31.85974 33.26412 1.000 48.10682  ? 691 HOH A O   1 
HETATM 3349 O O   . HOH C 3 .   ? 29.41737  20.13612 33.90225 1.000 61.11540  ? 692 HOH A O   1 
HETATM 3350 O O   . HOH C 3 .   ? 3.27196   34.89851 49.88737 1.000 77.94320  ? 693 HOH A O   1 
HETATM 3351 O O   . HOH C 3 .   ? -14.90879 18.77291 29.06015 1.000 45.88897  ? 694 HOH A O   1 
HETATM 3352 O O   . HOH C 3 .   ? 14.25067  11.41750 25.32876 1.000 79.11596  ? 695 HOH A O   1 
HETATM 3353 O O   . HOH C 3 .   ? 7.17784   46.32468 9.83328  1.000 80.86276  ? 696 HOH A O   1 
HETATM 3354 O O   . HOH C 3 .   ? 7.62156   18.74910 10.45951 1.000 52.03972  ? 697 HOH A O   1 
HETATM 3355 O O   . HOH C 3 .   ? 17.87909  37.13795 12.09033 1.000 67.66545  ? 698 HOH A O   1 
HETATM 3356 O O   . HOH C 3 .   ? 3.53471   33.68074 2.62998  1.000 44.69117  ? 699 HOH A O   1 
HETATM 3357 O O   . HOH C 3 .   ? 1.30360   15.00739 10.51334 1.000 49.84734  ? 700 HOH A O   1 
HETATM 3358 O O   . HOH C 3 .   ? 9.01286   41.66443 9.80421  1.000 60.31427  ? 701 HOH A O   1 
HETATM 3359 O O   . HOH C 3 .   ? -7.04818  32.78721 -1.85743 1.000 45.85305  ? 702 HOH A O   1 
HETATM 3360 O O   . HOH C 3 .   ? 16.63406  42.83927 41.48088 1.000 42.71187  ? 703 HOH A O   1 
HETATM 3361 O O   . HOH C 3 .   ? -1.22848  43.52941 9.53547  1.000 67.93131  ? 704 HOH A O   1 
HETATM 3362 O O   . HOH C 3 .   ? 16.68606  34.47161 24.93662 1.000 51.41659  ? 705 HOH A O   1 
HETATM 3363 O O   . HOH C 3 .   ? 18.97322  11.47681 27.84260 1.000 48.34141  ? 706 HOH A O   1 
HETATM 3364 O O   . HOH C 3 .   ? 11.82702  14.73234 28.33673 1.000 50.98830  ? 707 HOH A O   1 
HETATM 3365 O O   . HOH C 3 .   ? 3.49826   17.86942 1.13561  1.000 62.51908  ? 708 HOH A O   1 
HETATM 3366 O O   . HOH C 3 .   ? 1.36729   0.50465  2.86235  1.000 76.57898  ? 709 HOH A O   1 
HETATM 3367 O O   . HOH C 3 .   ? -7.66206  13.72452 2.69734  1.000 40.80063  ? 710 HOH A O   1 
HETATM 3368 O O   . HOH C 3 .   ? 10.09330  40.41556 8.09744  1.000 65.99556  ? 711 HOH A O   1 
HETATM 3369 O O   . HOH C 3 .   ? -2.87575  18.41523 16.26953 1.000 40.11808  ? 712 HOH A O   1 
HETATM 3370 O O   . HOH C 3 .   ? 5.09115   48.63339 31.29137 1.000 76.04665  ? 713 HOH A O   1 
HETATM 3371 O O   . HOH C 3 .   ? 20.25389  33.45778 37.79418 1.000 51.34872  ? 714 HOH A O   1 
HETATM 3372 O O   . HOH C 3 .   ? 19.25543  34.75363 25.72843 1.000 47.28184  ? 715 HOH A O   1 
HETATM 3373 O O   . HOH C 3 .   ? -8.97288  27.88832 29.46907 1.000 59.72334  ? 716 HOH A O   1 
HETATM 3374 O O   . HOH C 3 .   ? 1.53963   6.71445  27.48344 1.000 74.93365  ? 717 HOH A O   1 
HETATM 3375 O O   . HOH C 3 .   ? 2.20077   44.50307 31.77951 1.000 62.16626  ? 718 HOH A O   1 
HETATM 3376 O O   . HOH C 3 .   ? -25.04002 19.26342 2.40763  1.000 51.99603  ? 719 HOH A O   1 
HETATM 3377 O O   . HOH C 3 .   ? -2.77672  44.18901 3.24135  1.000 69.75837  ? 720 HOH A O   1 
HETATM 3378 O O   . HOH C 3 .   ? -2.20091  22.29957 27.64733 1.000 62.61418  ? 721 HOH A O   1 
HETATM 3379 O O   . HOH C 3 .   ? -23.17280 29.94235 19.05807 1.000 53.15888  ? 722 HOH A O   1 
HETATM 3380 O O   . HOH C 3 .   ? 24.33199  20.85754 38.71893 1.000 76.31686  ? 723 HOH A O   1 
HETATM 3381 O O   . HOH C 3 .   ? 26.71980  18.76737 29.91077 1.000 44.73366  ? 724 HOH A O   1 
HETATM 3382 O O   . HOH C 3 .   ? 6.15116   15.78505 23.18699 1.000 75.72964  ? 725 HOH A O   1 
HETATM 3383 O O   . HOH C 3 .   ? -3.76478  24.62763 28.21561 1.000 54.22170  ? 726 HOH A O   1 
HETATM 3384 O O   . HOH C 3 .   ? 12.08182  36.93484 8.08433  1.000 57.11483  ? 727 HOH A O   1 
HETATM 3385 O O   . HOH C 3 .   ? -1.90529  23.87592 0.02351  1.000 59.23020  ? 728 HOH A O   1 
HETATM 3386 O O   . HOH C 3 .   ? 0.03312   41.13681 16.56331 1.000 68.63009  ? 729 HOH A O   1 
HETATM 3387 O O   . HOH C 3 .   ? -14.02366 -4.05099 6.85791  1.000 67.33494  ? 730 HOH A O   1 
HETATM 3388 O O   . HOH C 3 .   ? 18.10579  8.62080  20.79089 1.000 75.82632  ? 731 HOH A O   1 
HETATM 3389 O O   . HOH C 3 .   ? -6.08124  11.90784 -3.65338 1.000 80.63919  ? 732 HOH A O   1 
HETATM 3390 O O   . HOH C 3 .   ? 8.14944   25.35186 7.81553  1.000 40.59888  ? 733 HOH A O   1 
HETATM 3391 O O   . HOH C 3 .   ? 14.94429  42.72573 31.87584 1.000 49.87596  ? 734 HOH A O   1 
HETATM 3392 O O   . HOH C 3 .   ? 6.79540   36.41120 2.89346  1.000 54.03975  ? 735 HOH A O   1 
HETATM 3393 O O   . HOH C 3 .   ? -13.47438 3.65740  5.49174  1.000 54.61948  ? 736 HOH A O   1 
HETATM 3394 O O   . HOH C 3 .   ? 24.14877  24.63485 27.38765 1.000 52.87565  ? 737 HOH A O   1 
HETATM 3395 O O   . HOH C 3 .   ? 19.58117  35.53567 35.80871 1.000 56.35356  ? 738 HOH A O   1 
HETATM 3396 O O   . HOH C 3 .   ? 2.05647   45.18855 8.58368  1.000 69.93842  ? 739 HOH A O   1 
HETATM 3397 O O   . HOH C 3 .   ? -9.28892  20.42093 0.22278  1.000 64.48701  ? 740 HOH A O   1 
HETATM 3398 O O   . HOH C 3 .   ? -22.07286 29.26735 11.30981 1.000 58.38548  ? 741 HOH A O   1 
HETATM 3399 O O   . HOH C 3 .   ? -12.51675 12.79665 1.25811  1.000 67.34188  ? 742 HOH A O   1 
HETATM 3400 O O   . HOH C 3 .   ? 15.51578  35.70107 11.22112 1.000 66.94501  ? 743 HOH A O   1 
HETATM 3401 O O   . HOH C 3 .   ? 2.79355   22.56617 7.53520  1.000 40.02332  ? 744 HOH A O   1 
HETATM 3402 O O   . HOH C 3 .   ? -10.69079 12.13968 3.86144  1.000 47.68406  ? 745 HOH A O   1 
HETATM 3403 O O   . HOH C 3 .   ? 15.03563  10.54969 21.77514 1.000 79.23463  ? 746 HOH A O   1 
HETATM 3404 O O   . HOH C 3 .   ? 23.61274  23.98024 14.92179 1.000 52.56613  ? 747 HOH A O   1 
HETATM 3405 O O   . HOH C 3 .   ? -16.49295 -0.68249 12.74358 1.000 51.32780  ? 748 HOH A O   1 
HETATM 3406 O O   . HOH C 3 .   ? 28.82714  30.17482 37.34562 1.000 61.24857  ? 749 HOH A O   1 
HETATM 3407 O O   . HOH C 3 .   ? -10.50055 31.48170 -2.29800 1.000 70.20000  ? 750 HOH A O   1 
HETATM 3408 O O   . HOH C 3 .   ? 1.63903   12.78871 9.33164  1.000 79.25570  ? 751 HOH A O   1 
HETATM 3409 O O   . HOH C 3 .   ? 22.97384  38.41508 36.74546 1.000 70.76849  ? 752 HOH A O   1 
HETATM 3410 O O   . HOH C 3 .   ? -23.65112 27.51800 16.03858 1.000 47.96313  ? 753 HOH A O   1 
HETATM 3411 O O   . HOH C 3 .   ? -4.03998  -2.85899 4.19688  1.000 67.74487  ? 754 HOH A O   1 
HETATM 3412 O O   . HOH C 3 .   ? 13.00174  13.28279 22.17028 1.000 67.39714  ? 755 HOH A O   1 
HETATM 3413 O O   . HOH C 3 .   ? 23.45311  9.91265  22.19277 1.000 59.03892  ? 756 HOH A O   1 
HETATM 3414 O O   . HOH C 3 .   ? 17.30793  26.63354 46.41305 1.000 67.53828  ? 757 HOH A O   1 
HETATM 3415 O O   . HOH C 3 .   ? -17.38663 26.53550 22.72997 1.000 63.22978  ? 758 HOH A O   1 
HETATM 3416 O O   . HOH C 3 .   ? -8.92393  24.67286 25.24729 1.000 41.80664  ? 759 HOH A O   1 
HETATM 3417 O O   . HOH C 3 .   ? 4.74273   27.17905 7.00932  1.000 33.44272  ? 760 HOH A O   1 
HETATM 3418 O O   . HOH C 3 .   ? 29.67124  27.00887 38.28115 1.000 64.17403  ? 761 HOH A O   1 
HETATM 3419 O O   . HOH C 3 .   ? -17.10904 19.07222 -1.36034 1.000 56.31231  ? 762 HOH A O   1 
HETATM 3420 O O   . HOH C 3 .   ? 0.19350   7.88656  30.32685 1.000 70.78558  ? 763 HOH A O   1 
HETATM 3421 O O   . HOH C 3 .   ? -1.70991  36.97314 -1.65359 1.000 60.66451  ? 764 HOH A O   1 
HETATM 3422 O O   . HOH C 3 .   ? 0.54668   29.50663 30.34310 1.000 77.05878  ? 765 HOH A O   1 
HETATM 3423 O O   . HOH C 3 .   ? -16.73232 6.92765  26.23354 1.000 51.96057  ? 766 HOH A O   1 
HETATM 3424 O O   . HOH C 3 .   ? 19.04258  26.71004 43.30319 1.000 45.18894  ? 767 HOH A O   1 
HETATM 3425 O O   . HOH C 3 .   ? 21.97297  30.79259 47.24719 1.000 71.11979  ? 768 HOH A O   1 
HETATM 3426 O O   . HOH C 3 .   ? 0.77509   25.67178 44.39444 1.000 88.24356  ? 769 HOH A O   1 
HETATM 3427 O O   . HOH C 3 .   ? 3.01562   13.19141 -0.86624 1.000 55.27309  ? 770 HOH A O   1 
HETATM 3428 O O   . HOH C 3 .   ? 6.11633   37.69401 24.85235 1.000 51.87507  ? 771 HOH A O   1 
HETATM 3429 O O   . HOH C 3 .   ? 16.87408  9.81066  22.35120 1.000 78.77847  ? 772 HOH A O   1 
HETATM 3430 O O   . HOH C 3 .   ? -12.66384 44.32411 14.29875 1.000 84.73282  ? 773 HOH A O   1 
HETATM 3431 O O   . HOH C 3 .   ? 5.71324   29.22904 25.06333 1.000 67.16263  ? 774 HOH A O   1 
HETATM 3432 O O   . HOH C 3 .   ? 4.46647   21.39709 5.82728  1.000 41.11489  ? 775 HOH A O   1 
HETATM 3433 O O   . HOH C 3 .   ? 5.45684   16.48866 4.85878  1.000 63.95416  ? 776 HOH A O   1 
HETATM 3434 O O   . HOH C 3 .   ? -3.25507  41.17447 0.65595  1.000 59.73723  ? 777 HOH A O   1 
HETATM 3435 O O   . HOH C 3 .   ? 2.26096   44.08782 17.53123 1.000 84.35521  ? 778 HOH A O   1 
HETATM 3436 O O   . HOH C 3 .   ? 4.45073   44.49105 0.75976  1.000 71.30323  ? 779 HOH A O   1 
HETATM 3437 O O   . HOH C 3 .   ? -22.304   10.491   19.725   1.000 66.40604  ? 780 HOH A O   1 
HETATM 3438 O O   . HOH C 3 .   ? 5.39681   4.55896  12.15214 1.000 76.19239  ? 781 HOH A O   1 
HETATM 3439 O O   . HOH C 3 .   ? 24.66381  17.11300 16.83843 1.000 40.61597  ? 782 HOH A O   1 
HETATM 3440 O O   . HOH C 3 .   ? -13.83237 40.02726 3.86844  1.000 59.76001  ? 783 HOH A O   1 
HETATM 3441 O O   . HOH C 3 .   ? 0.39762   34.22303 32.62826 1.000 62.08924  ? 784 HOH A O   1 
HETATM 3442 O O   . HOH C 3 .   ? 8.88890   22.38444 6.80593  1.000 46.06315  ? 785 HOH A O   1 
HETATM 3443 O O   . HOH C 3 .   ? 22.51038  33.05183 49.41541 1.000 72.00612  ? 786 HOH A O   1 
HETATM 3444 O O   . HOH C 3 .   ? -14.29507 30.76661 -1.92776 1.000 69.10963  ? 787 HOH A O   1 
HETATM 3445 O O   . HOH C 3 .   ? -22.84876 26.75604 11.92790 1.000 59.14804  ? 788 HOH A O   1 
HETATM 3446 O O   . HOH C 3 .   ? 10.63180  13.64251 43.94002 1.000 87.76249  ? 789 HOH A O   1 
HETATM 3447 O O   . HOH C 3 .   ? -15.91112 12.91498 -1.54141 1.000 43.26801  ? 790 HOH A O   1 
HETATM 3448 O O   . HOH C 3 .   ? 14.36833  16.27468 42.69746 1.000 77.37156  ? 791 HOH A O   1 
HETATM 3449 O O   . HOH C 3 .   ? 19.36218  36.52109 23.48031 1.000 60.09022  ? 792 HOH A O   1 
HETATM 3450 O O   . HOH C 3 .   ? -10.62773 26.44404 -4.31533 1.000 73.76754  ? 793 HOH A O   1 
HETATM 3451 O O   . HOH C 3 .   ? 0.74319   42.91443 40.68436 1.000 75.36957  ? 794 HOH A O   1 
HETATM 3452 O O   . HOH C 3 .   ? -16.60322 6.64962  -0.25768 1.000 68.00029  ? 795 HOH A O   1 
HETATM 3453 O O   . HOH C 3 .   ? -7.11165  7.19818  36.39348 1.000 80.28377  ? 796 HOH A O   1 
HETATM 3454 O O   . HOH C 3 .   ? 2.39579   11.11143 5.15670  1.000 66.08165  ? 797 HOH A O   1 
HETATM 3455 O O   . HOH C 3 .   ? 11.45338  48.04018 29.76923 1.000 65.79618  ? 798 HOH A O   1 
HETATM 3456 O O   . HOH C 3 .   ? -0.05382  40.44259 40.84396 1.000 70.03941  ? 799 HOH A O   1 
HETATM 3457 O O   . HOH C 3 .   ? -1.13267  28.01622 53.29703 1.000 88.10051  ? 800 HOH A O   1 
HETATM 3458 O O   . HOH C 3 .   ? 1.37884   42.08554 11.92638 1.000 70.25374  ? 801 HOH A O   1 
HETATM 3459 O O   . HOH C 3 .   ? 3.629     21.973   1.258    1.000 42.83150  ? 802 HOH A O   1 
HETATM 3460 O O   . HOH C 3 .   ? -13.66152 45.98692 15.51654 1.000 80.03570  ? 803 HOH A O   1 
HETATM 3461 O O   . HOH C 3 .   ? -8.27246  10.77342 2.41602  1.000 41.69198  ? 804 HOH A O   1 
HETATM 3462 O O   . HOH C 3 .   ? 13.82506  36.38941 15.44137 1.000 55.94888  ? 805 HOH A O   1 
HETATM 3463 O O   . HOH C 3 .   ? 3.45884   5.12020  14.06196 1.000 70.44414  ? 806 HOH A O   1 
HETATM 3464 O O   . HOH C 3 .   ? -9.97716  35.83917 32.80944 1.000 79.65011  ? 807 HOH A O   1 
HETATM 3465 O O   . HOH C 3 .   ? 20.34568  11.36332 15.39318 1.000 67.48174  ? 808 HOH A O   1 
HETATM 3466 O O   . HOH C 3 .   ? 10.27975  36.58823 5.82394  1.000 63.70957  ? 809 HOH A O   1 
HETATM 3467 O O   . HOH C 3 .   ? 3.72298   29.13707 30.20883 1.000 69.30357  ? 810 HOH A O   1 
HETATM 3468 O O   . HOH C 3 .   ? -18.79349 7.39771  -0.24298 1.000 56.62756  ? 811 HOH A O   1 
HETATM 3469 O O   . HOH C 3 .   ? 2.98128   12.16985 7.24860  1.000 75.21636  ? 812 HOH A O   1 
HETATM 3470 O O   . HOH C 3 .   ? 4.35024   15.09953 0.57541  1.000 59.38562  ? 813 HOH A O   1 
HETATM 3471 O O   . HOH C 3 .   ? -4.30699  46.66888 17.83586 1.000 77.63400  ? 814 HOH A O   1 
HETATM 3472 O O   . HOH C 3 .   ? -13.15212 -4.23709 4.25604  1.000 70.60976  ? 815 HOH A O   1 
HETATM 3473 O O   . HOH C 3 .   ? 8.32763   45.95027 7.16143  1.000 79.64895  ? 816 HOH A O   1 
HETATM 3474 O O   . HOH C 3 .   ? 26.49245  33.94146 40.31399 1.000 74.87981  ? 817 HOH A O   1 
HETATM 3475 O O   . HOH C 3 .   ? -0.93874  7.64491  19.88111 1.000 65.23752  ? 818 HOH A O   1 
HETATM 3476 O O   . HOH C 3 .   ? 24.22456  8.09887  28.93459 1.000 64.40439  ? 819 HOH A O   1 
HETATM 3477 O O   . HOH C 3 .   ? 0.48751   9.90145  20.37443 1.000 80.95536  ? 820 HOH A O   1 
HETATM 3478 O O   . HOH C 3 .   ? 4.20097   30.29906 32.85669 1.000 62.29514  ? 821 HOH A O   1 
HETATM 3479 O O   . HOH C 3 .   ? 9.08360   15.30156 22.68004 1.000 73.31539  ? 822 HOH A O   1 
HETATM 3480 O O   . HOH C 3 .   ? -11.08356 9.29567  -1.23043 1.000 78.73937  ? 823 HOH A O   1 
HETATM 3481 O O   . HOH C 3 .   ? 9.64470   38.48398 21.82238 1.000 72.31015  ? 824 HOH A O   1 
HETATM 3482 O O   . HOH C 3 .   ? -7.35868  7.66017  -3.44363 1.000 78.26502  ? 825 HOH A O   1 
HETATM 3483 O O   . HOH C 3 .   ? 19.13027  47.08941 40.43716 1.000 64.34497  ? 826 HOH A O   1 
HETATM 3484 O O   . HOH C 3 .   ? 28.65930  36.92522 40.38141 1.000 86.74423  ? 827 HOH A O   1 
HETATM 3485 O O   . HOH C 3 .   ? 5.94095   46.96491 11.45747 1.000 93.19660  ? 828 HOH A O   1 
HETATM 3486 O O   . HOH C 3 .   ? 20.63064  21.58771 13.51813 1.000 63.26682  ? 829 HOH A O   1 
HETATM 3487 O O   . HOH C 3 .   ? 19.95784  24.00568 13.17786 1.000 56.74841  ? 830 HOH A O   1 
HETATM 3488 O O   . HOH C 3 .   ? -10.76230 22.86931 -1.38056 1.000 60.27520  ? 831 HOH A O   1 
HETATM 3489 O O   . HOH C 3 .   ? 5.65575   19.32013 6.66740  1.000 49.66555  ? 832 HOH A O   1 
HETATM 3490 O O   . HOH C 3 .   ? -3.32988  33.08414 29.10117 1.000 54.76022  ? 833 HOH A O   1 
HETATM 3491 O O   . HOH C 3 .   ? 30.45880  40.74759 43.69007 1.000 75.53022  ? 834 HOH A O   1 
HETATM 3492 O O   . HOH C 3 .   ? 9.04288   23.48855 44.00103 1.000 71.08610  ? 835 HOH A O   1 
HETATM 3493 O O   . HOH C 3 .   ? -20.02285 23.34261 22.32012 1.000 53.54569  ? 836 HOH A O   1 
HETATM 3494 O O   . HOH C 3 .   ? -4.65781  30.90245 44.68619 1.000 80.23200  ? 837 HOH A O   1 
HETATM 3495 O O   . HOH C 3 .   ? 9.50817   14.18182 16.69302 1.000 71.57780  ? 838 HOH A O   1 
HETATM 3496 O O   . HOH C 3 .   ? -1.45552  41.86961 32.84355 1.000 64.14631  ? 839 HOH A O   1 
HETATM 3497 O O   . HOH C 3 .   ? 9.25005   19.90102 11.71683 1.000 66.47880  ? 840 HOH A O   1 
HETATM 3498 O O   . HOH C 3 .   ? 21.83824  34.99743 14.45900 1.000 87.85134  ? 841 HOH A O   1 
HETATM 3499 O O   . HOH C 3 .   ? -18.64897 -2.37096 5.82070  1.000 73.96039  ? 842 HOH A O   1 
HETATM 3500 O O   . HOH C 3 .   ? 23.79151  34.68507 39.82006 1.000 86.66781  ? 843 HOH A O   1 
HETATM 3501 O O   . HOH C 3 .   ? -4.16987  28.79972 43.02094 1.000 80.69127  ? 844 HOH A O   1 
HETATM 3502 O O   . HOH C 3 .   ? 1.76786   -3.73326 4.64318  1.000 70.25926  ? 845 HOH A O   1 
HETATM 3503 O O   . HOH C 3 .   ? 24.13713  18.04453 42.40685 1.000 74.53638  ? 846 HOH A O   1 
HETATM 3504 O O   . HOH C 3 .   ? -10.41744 11.49561 0.68759  1.000 75.99469  ? 847 HOH A O   1 
HETATM 3505 O O   . HOH C 3 .   ? 17.39513  34.63977 52.33937 1.000 83.41556  ? 848 HOH A O   1 
HETATM 3506 O O   . HOH C 3 .   ? -21.44221 18.84843 12.37354 1.000 80.40672  ? 849 HOH A O   1 
HETATM 3507 O O   . HOH C 3 .   ? 12.22232  5.90824  11.33082 1.000 74.94331  ? 850 HOH A O   1 
HETATM 3508 O O   . HOH C 3 .   ? -18.04154 42.66636 18.10981 1.000 81.94726  ? 851 HOH A O   1 
HETATM 3509 O O   . HOH C 3 .   ? 10.00811  13.34937 23.48401 1.000 71.86176  ? 852 HOH A O   1 
HETATM 3510 O O   . HOH C 3 .   ? -19.55384 42.09788 20.58955 1.000 80.95468  ? 853 HOH A O   1 
HETATM 3511 O O   . HOH C 3 .   ? -26.81174 18.87628 -0.09754 1.000 44.37257  ? 854 HOH A O   1 
HETATM 3512 O O   . HOH C 3 .   ? 10.19783  21.19927 20.13137 1.000 58.52623  ? 855 HOH A O   1 
HETATM 3513 O O   . HOH C 3 .   ? 31.90862  44.21564 42.27698 1.000 76.23736  ? 856 HOH A O   1 
HETATM 3514 O O   . HOH C 3 .   ? -3.30134  46.85727 4.13466  1.000 78.36171  ? 857 HOH A O   1 
HETATM 3515 O O   . HOH C 3 .   ? -8.00616  21.99191 27.57582 1.000 61.24441  ? 858 HOH A O   1 
HETATM 3516 O O   . HOH C 3 .   ? 6.30795   47.09736 14.88209 1.000 83.52378  ? 859 HOH A O   1 
HETATM 3517 O O   . HOH C 3 .   ? 6.15106   32.65817 2.31656  1.000 47.79707  ? 860 HOH A O   1 
HETATM 3518 O O   . HOH C 3 .   ? 5.80806   28.98670 29.03215 1.000 66.16512  ? 861 HOH A O   1 
HETATM 3519 O O   . HOH C 3 .   ? 29.70439  39.17616 35.55854 1.000 85.02473  ? 862 HOH A O   1 
HETATM 3520 O O   . HOH C 3 .   ? 3.21255   5.55963  -4.31293 1.000 59.66014  ? 863 HOH A O   1 
HETATM 3521 O O   . HOH C 3 .   ? 16.27482  6.62606  25.21745 1.000 72.01271  ? 864 HOH A O   1 
HETATM 3522 O O   . HOH C 3 .   ? -11.84247 1.45492  3.34926  1.000 69.70339  ? 865 HOH A O   1 
HETATM 3523 O O   . HOH C 3 .   ? 10.28653  45.17344 9.90171  1.000 74.97682  ? 866 HOH A O   1 
HETATM 3524 O O   . HOH C 3 .   ? 6.28290   26.02730 4.85688  1.000 46.67010  ? 867 HOH A O   1 
HETATM 3525 O O   . HOH C 3 .   ? -13.71816 9.23256  30.56145 1.000 71.65313  ? 868 HOH A O   1 
HETATM 3526 O O   . HOH C 3 .   ? 30.86048  24.55423 32.65819 1.000 66.61898  ? 869 HOH A O   1 
HETATM 3527 O O   . HOH C 3 .   ? -19.45869 23.27290 13.88933 1.000 55.25543  ? 870 HOH A O   1 
HETATM 3528 O O   . HOH C 3 .   ? -7.28492  47.96008 18.21289 1.000 79.69499  ? 871 HOH A O   1 
HETATM 3529 O O   . HOH C 3 .   ? 16.57930  37.48762 52.35039 1.000 74.79587  ? 872 HOH A O   1 
HETATM 3530 O O   . HOH C 3 .   ? 23.52480  39.40586 48.13275 1.000 79.65326  ? 873 HOH A O   1 
HETATM 3531 O O   . HOH C 3 .   ? -6.83005  20.67792 -0.44972 1.000 53.20329  ? 874 HOH A O   1 
HETATM 3532 O O   . HOH C 3 .   ? -2.76522  43.56064 42.36124 1.000 82.78544  ? 875 HOH A O   1 
HETATM 3533 O O   . HOH C 3 .   ? 8.96742   39.62047 14.84173 1.000 64.64929  ? 876 HOH A O   1 
HETATM 3534 O O   . HOH C 3 .   ? -19.49073 22.32595 -3.70286 1.000 34.53624  ? 877 HOH A O   1 
HETATM 3535 O O   . HOH C 3 .   ? 17.66296  43.03404 39.34101 1.000 56.71268  ? 878 HOH A O   1 
HETATM 3536 O O   . HOH C 3 .   ? 21.32633  39.20664 49.38755 1.000 79.78594  ? 879 HOH A O   1 
HETATM 3537 O O   . HOH C 3 .   ? -3.62441  38.76958 0.47048  1.000 53.87813  ? 880 HOH A O   1 
HETATM 3538 O O   . HOH C 3 .   ? -9.74225  -5.43637 4.17626  1.000 85.21348  ? 881 HOH A O   1 
HETATM 3539 O O   . HOH C 3 .   ? 1.18775   40.18902 -1.15017 1.000 65.66346  ? 882 HOH A O   1 
HETATM 3540 O O   . HOH C 3 .   ? 30.78092  22.04166 31.01309 1.000 62.84449  ? 883 HOH A O   1 
HETATM 3541 O O   . HOH C 3 .   ? -5.94387  17.73229 31.93566 1.000 69.42557  ? 884 HOH A O   1 
HETATM 3542 O O   . HOH C 3 .   ? 23.92783  45.35929 47.05287 1.000 78.16713  ? 885 HOH A O   1 
HETATM 3543 O O   . HOH C 3 .   ? 10.32367  42.65804 26.57328 1.000 69.97010  ? 886 HOH A O   1 
HETATM 3544 O O   . HOH C 3 .   ? 21.89115  25.61114 14.34168 1.000 46.52599  ? 887 HOH A O   1 
HETATM 3545 O O   . HOH C 3 .   ? 16.68075  9.11705  18.04032 1.000 59.50432  ? 888 HOH A O   1 
HETATM 3546 O O   . HOH C 3 .   ? -25.61458 31.69749 22.91354 1.000 61.43964  ? 889 HOH A O   1 
HETATM 3547 O O   . HOH C 3 .   ? -5.55285  38.21497 -1.25044 1.000 58.98868  ? 890 HOH A O   1 
HETATM 3548 O O   . HOH C 3 .   ? 9.58120   41.08504 17.75719 1.000 63.14457  ? 891 HOH A O   1 
HETATM 3549 O O   . HOH C 3 .   ? -6.58448  44.97973 0.31963  1.000 80.03901  ? 892 HOH A O   1 
HETATM 3550 O O   . HOH C 3 .   ? -1.76018  41.73755 37.67846 1.000 73.07613  ? 893 HOH A O   1 
HETATM 3551 O O   . HOH C 3 .   ? 11.78534  42.49875 29.09204 1.000 63.98759  ? 894 HOH A O   1 
HETATM 3552 O O   . HOH C 3 .   ? -13.49396 7.97790  -0.91471 1.000 76.70761  ? 895 HOH A O   1 
HETATM 3553 O O   . HOH C 3 .   ? 3.93477   47.58201 9.10793  1.000 75.10188  ? 896 HOH A O   1 
HETATM 3554 O O   . HOH C 3 .   ? -22.53075 21.82937 12.69906 1.000 60.60383  ? 897 HOH A O   1 
HETATM 3555 O O   . HOH C 3 .   ? 8.39953   29.40870 6.34305  1.000 47.53189  ? 898 HOH A O   1 
HETATM 3556 O O   . HOH C 3 .   ? 2.65626   5.84032  0.73802  1.000 61.74250  ? 899 HOH A O   1 
HETATM 3557 O O   . HOH C 3 .   ? -17.35789 21.88116 26.38750 1.000 53.48192  ? 900 HOH A O   1 
HETATM 3558 O O   . HOH C 3 .   ? -22.36677 9.02089  10.64385 1.000 76.56332  ? 901 HOH A O   1 
HETATM 3559 O O   . HOH C 3 .   ? -21.19811 6.17706  8.43294  1.000 72.16476  ? 902 HOH A O   1 
HETATM 3560 O O   . HOH C 3 .   ? -17.58775 -4.78606 6.97628  1.000 78.74347  ? 903 HOH A O   1 
HETATM 3561 O O   . HOH C 3 .   ? -4.25387  21.94803 28.96576 1.000 67.54531  ? 904 HOH A O   1 
HETATM 3562 O O   . HOH C 3 .   ? 13.78711  30.40132 57.58940 1.000 81.86798  ? 905 HOH A O   1 
HETATM 3563 O O   . HOH C 3 .   ? -9.78961  44.55434 16.41144 1.000 79.02607  ? 906 HOH A O   1 
HETATM 3564 O O   . HOH C 3 .   ? 15.95234  15.25726 45.42859 1.000 68.53440  ? 907 HOH A O   1 
HETATM 3565 O O   . HOH C 3 .   ? -22.79170 14.91899 2.27785  1.000 61.07666  ? 908 HOH A O   1 
HETATM 3566 O O   . HOH C 3 .   ? -23.60805 31.92186 12.86214 1.000 68.61959  ? 909 HOH A O   1 
HETATM 3567 O O   . HOH C 3 .   ? -11.81047 6.10837  -2.33165 1.000 80.60171  ? 910 HOH A O   1 
HETATM 3568 O O   . HOH C 3 .   ? 8.14316   30.38513 4.67316  1.000 64.84094  ? 911 HOH A O   1 
HETATM 3569 O O   . HOH C 3 .   ? -1.15575  28.92471 31.50644 1.000 87.39471  ? 912 HOH A O   1 
HETATM 3570 O O   . HOH C 3 .   ? 28.33747  20.31680 28.67567 1.000 55.58423  ? 913 HOH A O   1 
HETATM 3571 O O   . HOH C 3 .   ? -4.30454  43.17580 -1.11255 1.000 64.54554  ? 914 HOH A O   1 
HETATM 3572 O O   . HOH C 3 .   ? 23.05672  32.83325 37.53864 1.000 63.07642  ? 915 HOH A O   1 
HETATM 3573 O O   . HOH C 3 .   ? -15.76692 35.65986 -1.32362 1.000 61.46083  ? 916 HOH A O   1 
HETATM 3574 O O   . HOH C 3 .   ? 5.07281   17.92019 2.92827  1.000 58.62539  ? 917 HOH A O   1 
HETATM 3575 O O   . HOH C 3 .   ? 9.07115   49.24174 24.75897 1.000 82.62447  ? 918 HOH A O   1 
HETATM 3576 O O   . HOH C 3 .   ? 27.12526  13.43847 42.34911 1.000 78.17011  ? 919 HOH A O   1 
HETATM 3577 O O   . HOH C 3 .   ? -14.73704 38.96167 0.75942  1.000 64.97230  ? 920 HOH A O   1 
HETATM 3578 O O   . HOH C 3 .   ? -2.37123  6.67137  22.00070 1.000 77.81378  ? 921 HOH A O   1 
HETATM 3579 O O   . HOH C 3 .   ? -25.566   15.803   14.394   1.000 73.62043  ? 922 HOH A O   1 
HETATM 3580 O O   . HOH C 3 .   ? -6.28120  12.31953 38.23880 1.000 75.70734  ? 923 HOH A O   1 
HETATM 3581 O O   . HOH C 3 .   ? 9.25839   24.90439 53.51384 1.000 81.49759  ? 924 HOH A O   1 
HETATM 3582 O O   . HOH C 3 .   ? -0.79942  31.69952 -2.66644 1.000 60.45364  ? 925 HOH A O   1 
HETATM 3583 O O   . HOH C 3 .   ? -11.32823 19.08436 -0.46821 1.000 62.00463  ? 926 HOH A O   1 
HETATM 3584 O O   . HOH C 3 .   ? 23.00824  36.29531 37.80502 1.000 62.70613  ? 927 HOH A O   1 
HETATM 3585 O O   . HOH C 3 .   ? 12.86658  39.10710 11.88566 1.000 64.74070  ? 928 HOH A O   1 
HETATM 3586 O O   . HOH C 3 .   ? -25.41832 35.58286 9.05055  1.000 69.60241  ? 929 HOH A O   1 
HETATM 3587 O O   . HOH C 3 .   ? 20.17964  40.19189 36.00014 1.000 68.26002  ? 930 HOH A O   1 
HETATM 3588 O O   . HOH C 3 .   ? -24.17453 19.43312 9.84720  1.000 68.07192  ? 931 HOH A O   1 
HETATM 3589 O O   . HOH C 3 .   ? 29.95786  28.08064 34.71411 1.000 70.73843  ? 932 HOH A O   1 
HETATM 3590 O O   . HOH C 3 .   ? -5.50378  36.74951 -3.56404 1.000 69.48513  ? 933 HOH A O   1 
HETATM 3591 O O   . HOH C 3 .   ? 14.33697  10.75392 27.59891 1.000 75.82392  ? 934 HOH A O   1 
HETATM 3592 O O   . HOH C 3 .   ? -15.70535 37.44303 30.72757 1.000 81.06642  ? 935 HOH A O   1 
HETATM 3593 O O   . HOH C 3 .   ? -6.66700  40.12454 33.36607 1.000 80.01936  ? 936 HOH A O   1 
HETATM 3594 O O   . HOH C 3 .   ? 19.38579  42.68297 32.94202 1.000 66.59606  ? 937 HOH A O   1 
HETATM 3595 O O   . HOH C 3 .   ? -11.00437 38.09525 -2.22059 1.000 64.76615  ? 938 HOH A O   1 
HETATM 3596 O O   . HOH C 3 .   ? -0.45686  32.54041 33.96632 1.000 66.57220  ? 939 HOH A O   1 
HETATM 3597 O O   . HOH C 3 .   ? 20.66035  39.64410 51.70927 1.000 64.34220  ? 940 HOH A O   1 
HETATM 3598 O O   . HOH C 3 .   ? -3.51259  51.85238 21.48055 1.000 86.33675  ? 941 HOH A O   1 
HETATM 3599 O O   . HOH C 3 .   ? 12.13518  39.34411 8.96934  1.000 67.74064  ? 942 HOH A O   1 
HETATM 3600 O O   . HOH C 3 .   ? 11.18796  28.80848 5.97829  1.000 58.50874  ? 943 HOH A O   1 
HETATM 3601 O O   . HOH C 3 .   ? -17.90678 6.23961  10.51385 1.000 60.00626  ? 944 HOH A O   1 
HETATM 3602 O O   . HOH C 3 .   ? -10.95690 38.68588 30.28401 1.000 74.95642  ? 945 HOH A O   1 
HETATM 3603 O O   . HOH C 3 .   ? 16.31755  47.33895 20.46757 1.000 77.52056  ? 946 HOH A O   1 
HETATM 3604 O O   . HOH C 3 .   ? -9.75863  33.32751 -3.20585 1.000 67.00767  ? 947 HOH A O   1 
HETATM 3605 O O   . HOH C 3 .   ? -5.72735  45.31784 14.15336 1.000 71.83692  ? 948 HOH A O   1 
HETATM 3606 O O   . HOH C 3 .   ? 21.34832  6.82056  32.11000 1.000 67.34021  ? 949 HOH A O   1 
HETATM 3607 O O   . HOH C 3 .   ? -20.33411 53.49498 22.38575 1.000 72.32092  ? 950 HOH A O   1 
HETATM 3608 O O   . HOH C 3 .   ? 34.29668  24.12561 38.07805 1.000 74.20104  ? 951 HOH A O   1 
HETATM 3609 O O   . HOH C 3 .   ? 14.84519  35.25603 7.27077  1.000 77.26441  ? 952 HOH A O   1 
HETATM 3610 O O   . HOH C 3 .   ? 13.43668  18.28948 49.63198 1.000 79.38351  ? 953 HOH A O   1 
HETATM 3611 O O   . HOH C 3 .   ? 1.23115   31.51947 32.79920 1.000 66.51220  ? 954 HOH A O   1 
HETATM 3612 O O   . HOH C 3 .   ? 23.20888  41.36460 30.04392 1.000 77.89556  ? 955 HOH A O   1 
HETATM 3613 O O   . HOH C 3 .   ? -30.05579 26.12173 0.81602  1.000 56.17767  ? 956 HOH A O   1 
HETATM 3614 O O   . HOH C 3 .   ? 7.58208   13.71299 45.54660 1.000 71.24133  ? 957 HOH A O   1 
HETATM 3615 O O   . HOH C 3 .   ? 27.98927  33.37338 36.00002 1.000 73.23003  ? 958 HOH A O   1 
HETATM 3616 O O   . HOH C 3 .   ? -4.69704  28.48570 47.86813 1.000 77.83072  ? 959 HOH A O   1 
HETATM 3617 O O   . HOH C 3 .   ? -5.03860  44.46769 37.56418 1.000 71.09711  ? 960 HOH A O   1 
HETATM 3618 O O   . HOH C 3 .   ? 4.32273   7.48157  2.35648  1.000 55.79061  ? 961 HOH A O   1 
HETATM 3619 O O   . HOH C 3 .   ? 29.10853  46.23341 46.31507 1.000 65.91535  ? 962 HOH A O   1 
HETATM 3620 O O   . HOH C 3 .   ? 16.95368  14.55328 12.36485 1.000 80.71517  ? 963 HOH A O   1 
HETATM 3621 O O   . HOH C 3 .   ? 9.74144   11.21924 19.74084 1.000 83.00545  ? 964 HOH A O   1 
HETATM 3622 O O   . HOH C 3 .   ? -9.64851  13.26725 -1.22772 1.000 67.08160  ? 965 HOH A O   1 
HETATM 3623 O O   . HOH C 3 .   ? -20.69859 45.01358 7.41631  1.000 73.24624  ? 966 HOH A O   1 
HETATM 3624 O O   . HOH C 3 .   ? 6.25382   50.44927 2.52254  1.000 74.99371  ? 967 HOH A O   1 
HETATM 3625 O O   . HOH C 3 .   ? 3.19594   49.96345 18.47524 1.000 70.30577  ? 968 HOH A O   1 
HETATM 3626 O O   . HOH C 3 .   ? -10.62710 11.16547 39.73668 1.000 81.98614  ? 969 HOH A O   1 
HETATM 3627 O O   . HOH C 3 .   ? -25.23283 13.08156 4.66243  1.000 73.11296  ? 970 HOH A O   1 
HETATM 3628 O O   . HOH C 3 .   ? 7.59550   3.95544  5.53223  1.000 73.90003  ? 971 HOH A O   1 
HETATM 3629 O O   . HOH C 3 .   ? 14.92999  42.03142 14.46512 1.000 83.20327  ? 972 HOH A O   1 
HETATM 3630 O O   . HOH C 3 .   ? -22.40773 49.61363 22.90025 1.000 71.03952  ? 973 HOH A O   1 
HETATM 3631 O O   . HOH C 3 .   ? 15.11940  1.31821  10.44728 1.000 64.95377  ? 974 HOH A O   1 
HETATM 3632 O O   . HOH C 3 .   ? -5.70170  -2.80573 -5.07962 1.000 80.38232  ? 975 HOH A O   1 
HETATM 3633 O O   . HOH C 3 .   ? -6.93772  18.34497 46.75265 1.000 76.44358  ? 976 HOH A O   1 
HETATM 3634 O O   . HOH C 3 .   ? 6.82590   53.65691 2.93195  1.000 81.39886  ? 977 HOH A O   1 
HETATM 3635 O O   . HOH C 3 .   ? 17.27435  51.67261 8.58779  1.000 80.50533  ? 978 HOH A O   1 
# 
