data_8X1L
# 
_entry.id   8X1L 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8X1L         pdb_00008x1l 10.2210/pdb8x1l/pdb 
WWPDB D_1300042457 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-13 
2 'Structure model' 1 1 2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.page_last'               
2 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
3 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8X1L 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hackwondo@kopri.re.kr 
_pdbx_contact_author.name_first         Hackwon 
_pdbx_contact_author.name_last          Do 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7663-2010 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Nam, Y.' 1 ? 
'Do, H.'  2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Sci Rep' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2045-2322 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            14 
_citation.language                  ? 
_citation.page_first                3234 
_citation.page_last                 3234 
_citation.title                     
;Engineered ice-binding protein (FfIBP) shows increased stability and resistance to thermal and chemical denaturation compared to the wildtype.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41598-024-53864-w 
_citation.pdbx_database_id_PubMed   38331970 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Nam, Y.'      1 ? 
primary 'Nguyen, D.L.' 2 ? 
primary 'Hoang, T.'    3 ? 
primary 'Kim, B.'      4 ? 
primary 'Lee, J.H.'    5 ? 
primary 'Do, H.'       6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Ice-binding protein' 25736.971 1   ? 'S96C, L132C' ? ? 
2 water   nat water                 18.015    103 ? ?             ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;HMSLSVANSTYETTALNSQKSSTDQPNSGSKSGQTLDLVNLGVAANFAILSKTGITDVYKSAITGDVGACPITGAAILLK
CDEVTGTIFSVDAAGPACKITDASRCTTAVGDMQIAYDNAAGRLNPDFLNLGAGTIGGKTLTPGLYKWTSTLNIPTDITI
SGSSTDVWIFQVAGNLNMSSAVRITLAGGAQAKNIFWQTAGAVTLGSTSHFEGNILSQTGINMKTAASINGRMMAQTAVT
LQMNTVTIPQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;HMSLSVANSTYETTALNSQKSSTDQPNSGSKSGQTLDLVNLGVAANFAILSKTGITDVYKSAITGDVGACPITGAAILLK
CDEVTGTIFSVDAAGPACKITDASRCTTAVGDMQIAYDNAAGRLNPDFLNLGAGTIGGKTLTPGLYKWTSTLNIPTDITI
SGSSTDVWIFQVAGNLNMSSAVRITLAGGAQAKNIFWQTAGAVTLGSTSHFEGNILSQTGINMKTAASINGRMMAQTAVT
LQMNTVTIPQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   HIS n 
1 2   MET n 
1 3   SER n 
1 4   LEU n 
1 5   SER n 
1 6   VAL n 
1 7   ALA n 
1 8   ASN n 
1 9   SER n 
1 10  THR n 
1 11  TYR n 
1 12  GLU n 
1 13  THR n 
1 14  THR n 
1 15  ALA n 
1 16  LEU n 
1 17  ASN n 
1 18  SER n 
1 19  GLN n 
1 20  LYS n 
1 21  SER n 
1 22  SER n 
1 23  THR n 
1 24  ASP n 
1 25  GLN n 
1 26  PRO n 
1 27  ASN n 
1 28  SER n 
1 29  GLY n 
1 30  SER n 
1 31  LYS n 
1 32  SER n 
1 33  GLY n 
1 34  GLN n 
1 35  THR n 
1 36  LEU n 
1 37  ASP n 
1 38  LEU n 
1 39  VAL n 
1 40  ASN n 
1 41  LEU n 
1 42  GLY n 
1 43  VAL n 
1 44  ALA n 
1 45  ALA n 
1 46  ASN n 
1 47  PHE n 
1 48  ALA n 
1 49  ILE n 
1 50  LEU n 
1 51  SER n 
1 52  LYS n 
1 53  THR n 
1 54  GLY n 
1 55  ILE n 
1 56  THR n 
1 57  ASP n 
1 58  VAL n 
1 59  TYR n 
1 60  LYS n 
1 61  SER n 
1 62  ALA n 
1 63  ILE n 
1 64  THR n 
1 65  GLY n 
1 66  ASP n 
1 67  VAL n 
1 68  GLY n 
1 69  ALA n 
1 70  CYS n 
1 71  PRO n 
1 72  ILE n 
1 73  THR n 
1 74  GLY n 
1 75  ALA n 
1 76  ALA n 
1 77  ILE n 
1 78  LEU n 
1 79  LEU n 
1 80  LYS n 
1 81  CYS n 
1 82  ASP n 
1 83  GLU n 
1 84  VAL n 
1 85  THR n 
1 86  GLY n 
1 87  THR n 
1 88  ILE n 
1 89  PHE n 
1 90  SER n 
1 91  VAL n 
1 92  ASP n 
1 93  ALA n 
1 94  ALA n 
1 95  GLY n 
1 96  PRO n 
1 97  ALA n 
1 98  CYS n 
1 99  LYS n 
1 100 ILE n 
1 101 THR n 
1 102 ASP n 
1 103 ALA n 
1 104 SER n 
1 105 ARG n 
1 106 CYS n 
1 107 THR n 
1 108 THR n 
1 109 ALA n 
1 110 VAL n 
1 111 GLY n 
1 112 ASP n 
1 113 MET n 
1 114 GLN n 
1 115 ILE n 
1 116 ALA n 
1 117 TYR n 
1 118 ASP n 
1 119 ASN n 
1 120 ALA n 
1 121 ALA n 
1 122 GLY n 
1 123 ARG n 
1 124 LEU n 
1 125 ASN n 
1 126 PRO n 
1 127 ASP n 
1 128 PHE n 
1 129 LEU n 
1 130 ASN n 
1 131 LEU n 
1 132 GLY n 
1 133 ALA n 
1 134 GLY n 
1 135 THR n 
1 136 ILE n 
1 137 GLY n 
1 138 GLY n 
1 139 LYS n 
1 140 THR n 
1 141 LEU n 
1 142 THR n 
1 143 PRO n 
1 144 GLY n 
1 145 LEU n 
1 146 TYR n 
1 147 LYS n 
1 148 TRP n 
1 149 THR n 
1 150 SER n 
1 151 THR n 
1 152 LEU n 
1 153 ASN n 
1 154 ILE n 
1 155 PRO n 
1 156 THR n 
1 157 ASP n 
1 158 ILE n 
1 159 THR n 
1 160 ILE n 
1 161 SER n 
1 162 GLY n 
1 163 SER n 
1 164 SER n 
1 165 THR n 
1 166 ASP n 
1 167 VAL n 
1 168 TRP n 
1 169 ILE n 
1 170 PHE n 
1 171 GLN n 
1 172 VAL n 
1 173 ALA n 
1 174 GLY n 
1 175 ASN n 
1 176 LEU n 
1 177 ASN n 
1 178 MET n 
1 179 SER n 
1 180 SER n 
1 181 ALA n 
1 182 VAL n 
1 183 ARG n 
1 184 ILE n 
1 185 THR n 
1 186 LEU n 
1 187 ALA n 
1 188 GLY n 
1 189 GLY n 
1 190 ALA n 
1 191 GLN n 
1 192 ALA n 
1 193 LYS n 
1 194 ASN n 
1 195 ILE n 
1 196 PHE n 
1 197 TRP n 
1 198 GLN n 
1 199 THR n 
1 200 ALA n 
1 201 GLY n 
1 202 ALA n 
1 203 VAL n 
1 204 THR n 
1 205 LEU n 
1 206 GLY n 
1 207 SER n 
1 208 THR n 
1 209 SER n 
1 210 HIS n 
1 211 PHE n 
1 212 GLU n 
1 213 GLY n 
1 214 ASN n 
1 215 ILE n 
1 216 LEU n 
1 217 SER n 
1 218 GLN n 
1 219 THR n 
1 220 GLY n 
1 221 ILE n 
1 222 ASN n 
1 223 MET n 
1 224 LYS n 
1 225 THR n 
1 226 ALA n 
1 227 ALA n 
1 228 SER n 
1 229 ILE n 
1 230 ASN n 
1 231 GLY n 
1 232 ARG n 
1 233 MET n 
1 234 MET n 
1 235 ALA n 
1 236 GLN n 
1 237 THR n 
1 238 ALA n 
1 239 VAL n 
1 240 THR n 
1 241 LEU n 
1 242 GLN n 
1 243 MET n 
1 244 ASN n 
1 245 THR n 
1 246 VAL n 
1 247 THR n 
1 248 ILE n 
1 249 PRO n 
1 250 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   250 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 HJ01_03463 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Flavobacterium frigoris PS1' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1086011 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   HIS 1   27  ?   ?   ?   A . n 
A 1 2   MET 2   28  ?   ?   ?   A . n 
A 1 3   SER 3   29  ?   ?   ?   A . n 
A 1 4   LEU 4   30  ?   ?   ?   A . n 
A 1 5   SER 5   31  ?   ?   ?   A . n 
A 1 6   VAL 6   32  ?   ?   ?   A . n 
A 1 7   ALA 7   33  ?   ?   ?   A . n 
A 1 8   ASN 8   34  ?   ?   ?   A . n 
A 1 9   SER 9   35  ?   ?   ?   A . n 
A 1 10  THR 10  36  ?   ?   ?   A . n 
A 1 11  TYR 11  37  ?   ?   ?   A . n 
A 1 12  GLU 12  38  ?   ?   ?   A . n 
A 1 13  THR 13  39  ?   ?   ?   A . n 
A 1 14  THR 14  40  ?   ?   ?   A . n 
A 1 15  ALA 15  41  ?   ?   ?   A . n 
A 1 16  LEU 16  42  ?   ?   ?   A . n 
A 1 17  ASN 17  43  ?   ?   ?   A . n 
A 1 18  SER 18  44  ?   ?   ?   A . n 
A 1 19  GLN 19  45  ?   ?   ?   A . n 
A 1 20  LYS 20  46  ?   ?   ?   A . n 
A 1 21  SER 21  47  ?   ?   ?   A . n 
A 1 22  SER 22  48  ?   ?   ?   A . n 
A 1 23  THR 23  49  ?   ?   ?   A . n 
A 1 24  ASP 24  50  ?   ?   ?   A . n 
A 1 25  GLN 25  51  ?   ?   ?   A . n 
A 1 26  PRO 26  52  ?   ?   ?   A . n 
A 1 27  ASN 27  53  ?   ?   ?   A . n 
A 1 28  SER 28  54  ?   ?   ?   A . n 
A 1 29  GLY 29  55  ?   ?   ?   A . n 
A 1 30  SER 30  56  ?   ?   ?   A . n 
A 1 31  LYS 31  57  ?   ?   ?   A . n 
A 1 32  SER 32  58  ?   ?   ?   A . n 
A 1 33  GLY 33  59  ?   ?   ?   A . n 
A 1 34  GLN 34  60  ?   ?   ?   A . n 
A 1 35  THR 35  61  61  THR THR A . n 
A 1 36  LEU 36  62  62  LEU LEU A . n 
A 1 37  ASP 37  63  63  ASP ASP A . n 
A 1 38  LEU 38  64  64  LEU LEU A . n 
A 1 39  VAL 39  65  65  VAL VAL A . n 
A 1 40  ASN 40  66  66  ASN ASN A . n 
A 1 41  LEU 41  67  67  LEU LEU A . n 
A 1 42  GLY 42  68  68  GLY GLY A . n 
A 1 43  VAL 43  69  69  VAL VAL A . n 
A 1 44  ALA 44  70  70  ALA ALA A . n 
A 1 45  ALA 45  71  71  ALA ALA A . n 
A 1 46  ASN 46  72  72  ASN ASN A . n 
A 1 47  PHE 47  73  73  PHE PHE A . n 
A 1 48  ALA 48  74  74  ALA ALA A . n 
A 1 49  ILE 49  75  75  ILE ILE A . n 
A 1 50  LEU 50  76  76  LEU LEU A . n 
A 1 51  SER 51  77  77  SER SER A . n 
A 1 52  LYS 52  78  78  LYS LYS A . n 
A 1 53  THR 53  79  79  THR THR A . n 
A 1 54  GLY 54  80  80  GLY GLY A . n 
A 1 55  ILE 55  81  81  ILE ILE A . n 
A 1 56  THR 56  82  82  THR THR A . n 
A 1 57  ASP 57  83  83  ASP ASP A . n 
A 1 58  VAL 58  84  84  VAL VAL A . n 
A 1 59  TYR 59  85  85  TYR TYR A . n 
A 1 60  LYS 60  86  86  LYS LYS A . n 
A 1 61  SER 61  87  87  SER SER A . n 
A 1 62  ALA 62  88  88  ALA ALA A . n 
A 1 63  ILE 63  89  89  ILE ILE A . n 
A 1 64  THR 64  90  90  THR THR A . n 
A 1 65  GLY 65  91  91  GLY GLY A . n 
A 1 66  ASP 66  92  92  ASP ASP A . n 
A 1 67  VAL 67  93  93  VAL VAL A . n 
A 1 68  GLY 68  94  94  GLY GLY A . n 
A 1 69  ALA 69  95  95  ALA ALA A . n 
A 1 70  CYS 70  96  96  CYS CYS A . n 
A 1 71  PRO 71  97  97  PRO PRO A . n 
A 1 72  ILE 72  98  98  ILE ILE A . n 
A 1 73  THR 73  99  99  THR THR A . n 
A 1 74  GLY 74  100 100 GLY GLY A . n 
A 1 75  ALA 75  101 101 ALA ALA A . n 
A 1 76  ALA 76  102 102 ALA ALA A . n 
A 1 77  ILE 77  103 103 ILE ILE A . n 
A 1 78  LEU 78  104 104 LEU LEU A . n 
A 1 79  LEU 79  105 105 LEU LEU A . n 
A 1 80  LYS 80  106 106 LYS LYS A . n 
A 1 81  CYS 81  107 107 CYS CYS A . n 
A 1 82  ASP 82  108 108 ASP ASP A . n 
A 1 83  GLU 83  109 109 GLU GLU A . n 
A 1 84  VAL 84  110 110 VAL VAL A . n 
A 1 85  THR 85  111 111 THR THR A . n 
A 1 86  GLY 86  112 112 GLY GLY A . n 
A 1 87  THR 87  113 113 THR THR A . n 
A 1 88  ILE 88  114 114 ILE ILE A . n 
A 1 89  PHE 89  115 115 PHE PHE A . n 
A 1 90  SER 90  116 116 SER SER A . n 
A 1 91  VAL 91  117 117 VAL VAL A . n 
A 1 92  ASP 92  118 118 ASP ASP A . n 
A 1 93  ALA 93  119 119 ALA ALA A . n 
A 1 94  ALA 94  120 120 ALA ALA A . n 
A 1 95  GLY 95  121 121 GLY GLY A . n 
A 1 96  PRO 96  122 122 PRO PRO A . n 
A 1 97  ALA 97  123 123 ALA ALA A . n 
A 1 98  CYS 98  124 124 CYS CYS A . n 
A 1 99  LYS 99  125 125 LYS LYS A . n 
A 1 100 ILE 100 126 126 ILE ILE A . n 
A 1 101 THR 101 127 127 THR THR A . n 
A 1 102 ASP 102 128 128 ASP ASP A . n 
A 1 103 ALA 103 129 129 ALA ALA A . n 
A 1 104 SER 104 130 130 SER SER A . n 
A 1 105 ARG 105 131 131 ARG ARG A . n 
A 1 106 CYS 106 132 132 CYS CYS A . n 
A 1 107 THR 107 133 133 THR THR A . n 
A 1 108 THR 108 134 134 THR THR A . n 
A 1 109 ALA 109 135 135 ALA ALA A . n 
A 1 110 VAL 110 136 136 VAL VAL A . n 
A 1 111 GLY 111 137 137 GLY GLY A . n 
A 1 112 ASP 112 138 138 ASP ASP A . n 
A 1 113 MET 113 139 139 MET MET A . n 
A 1 114 GLN 114 140 140 GLN GLN A . n 
A 1 115 ILE 115 141 141 ILE ILE A . n 
A 1 116 ALA 116 142 142 ALA ALA A . n 
A 1 117 TYR 117 143 143 TYR TYR A . n 
A 1 118 ASP 118 144 144 ASP ASP A . n 
A 1 119 ASN 119 145 145 ASN ASN A . n 
A 1 120 ALA 120 146 146 ALA ALA A . n 
A 1 121 ALA 121 147 147 ALA ALA A . n 
A 1 122 GLY 122 148 148 GLY GLY A . n 
A 1 123 ARG 123 149 149 ARG ARG A . n 
A 1 124 LEU 124 150 150 LEU LEU A . n 
A 1 125 ASN 125 151 151 ASN ASN A . n 
A 1 126 PRO 126 152 152 PRO PRO A . n 
A 1 127 ASP 127 153 153 ASP ASP A . n 
A 1 128 PHE 128 154 154 PHE PHE A . n 
A 1 129 LEU 129 155 155 LEU LEU A . n 
A 1 130 ASN 130 156 156 ASN ASN A . n 
A 1 131 LEU 131 157 157 LEU LEU A . n 
A 1 132 GLY 132 158 158 GLY GLY A . n 
A 1 133 ALA 133 159 159 ALA ALA A . n 
A 1 134 GLY 134 160 160 GLY GLY A . n 
A 1 135 THR 135 161 161 THR THR A . n 
A 1 136 ILE 136 162 162 ILE ILE A . n 
A 1 137 GLY 137 163 163 GLY GLY A . n 
A 1 138 GLY 138 164 164 GLY GLY A . n 
A 1 139 LYS 139 165 165 LYS LYS A . n 
A 1 140 THR 140 166 166 THR THR A . n 
A 1 141 LEU 141 167 167 LEU LEU A . n 
A 1 142 THR 142 168 168 THR THR A . n 
A 1 143 PRO 143 169 169 PRO PRO A . n 
A 1 144 GLY 144 170 170 GLY GLY A . n 
A 1 145 LEU 145 171 171 LEU LEU A . n 
A 1 146 TYR 146 172 172 TYR TYR A . n 
A 1 147 LYS 147 173 173 LYS LYS A . n 
A 1 148 TRP 148 174 174 TRP TRP A . n 
A 1 149 THR 149 175 175 THR THR A . n 
A 1 150 SER 150 176 176 SER SER A . n 
A 1 151 THR 151 177 177 THR THR A . n 
A 1 152 LEU 152 178 178 LEU LEU A . n 
A 1 153 ASN 153 179 179 ASN ASN A . n 
A 1 154 ILE 154 180 180 ILE ILE A . n 
A 1 155 PRO 155 181 181 PRO PRO A . n 
A 1 156 THR 156 182 182 THR THR A . n 
A 1 157 ASP 157 183 183 ASP ASP A . n 
A 1 158 ILE 158 184 184 ILE ILE A . n 
A 1 159 THR 159 185 185 THR THR A . n 
A 1 160 ILE 160 186 186 ILE ILE A . n 
A 1 161 SER 161 187 187 SER SER A . n 
A 1 162 GLY 162 188 188 GLY GLY A . n 
A 1 163 SER 163 189 189 SER SER A . n 
A 1 164 SER 164 190 190 SER SER A . n 
A 1 165 THR 165 191 191 THR THR A . n 
A 1 166 ASP 166 192 192 ASP ASP A . n 
A 1 167 VAL 167 193 193 VAL VAL A . n 
A 1 168 TRP 168 194 194 TRP TRP A . n 
A 1 169 ILE 169 195 195 ILE ILE A . n 
A 1 170 PHE 170 196 196 PHE PHE A . n 
A 1 171 GLN 171 197 197 GLN GLN A . n 
A 1 172 VAL 172 198 198 VAL VAL A . n 
A 1 173 ALA 173 199 199 ALA ALA A . n 
A 1 174 GLY 174 200 200 GLY GLY A . n 
A 1 175 ASN 175 201 201 ASN ASN A . n 
A 1 176 LEU 176 202 202 LEU LEU A . n 
A 1 177 ASN 177 203 203 ASN ASN A . n 
A 1 178 MET 178 204 204 MET MET A . n 
A 1 179 SER 179 205 205 SER SER A . n 
A 1 180 SER 180 206 206 SER SER A . n 
A 1 181 ALA 181 207 207 ALA ALA A . n 
A 1 182 VAL 182 208 208 VAL VAL A . n 
A 1 183 ARG 183 209 209 ARG ARG A . n 
A 1 184 ILE 184 210 210 ILE ILE A . n 
A 1 185 THR 185 211 211 THR THR A . n 
A 1 186 LEU 186 212 212 LEU LEU A . n 
A 1 187 ALA 187 213 213 ALA ALA A . n 
A 1 188 GLY 188 214 214 GLY GLY A . n 
A 1 189 GLY 189 215 215 GLY GLY A . n 
A 1 190 ALA 190 216 216 ALA ALA A . n 
A 1 191 GLN 191 217 217 GLN GLN A . n 
A 1 192 ALA 192 218 218 ALA ALA A . n 
A 1 193 LYS 193 219 219 LYS LYS A . n 
A 1 194 ASN 194 220 220 ASN ASN A . n 
A 1 195 ILE 195 221 221 ILE ILE A . n 
A 1 196 PHE 196 222 222 PHE PHE A . n 
A 1 197 TRP 197 223 223 TRP TRP A . n 
A 1 198 GLN 198 224 224 GLN GLN A . n 
A 1 199 THR 199 225 225 THR THR A . n 
A 1 200 ALA 200 226 226 ALA ALA A . n 
A 1 201 GLY 201 227 227 GLY GLY A . n 
A 1 202 ALA 202 228 228 ALA ALA A . n 
A 1 203 VAL 203 229 229 VAL VAL A . n 
A 1 204 THR 204 230 230 THR THR A . n 
A 1 205 LEU 205 231 231 LEU LEU A . n 
A 1 206 GLY 206 232 232 GLY GLY A . n 
A 1 207 SER 207 233 233 SER SER A . n 
A 1 208 THR 208 234 234 THR THR A . n 
A 1 209 SER 209 235 235 SER SER A . n 
A 1 210 HIS 210 236 236 HIS HIS A . n 
A 1 211 PHE 211 237 237 PHE PHE A . n 
A 1 212 GLU 212 238 238 GLU GLU A . n 
A 1 213 GLY 213 239 239 GLY GLY A . n 
A 1 214 ASN 214 240 240 ASN ASN A . n 
A 1 215 ILE 215 241 241 ILE ILE A . n 
A 1 216 LEU 216 242 242 LEU LEU A . n 
A 1 217 SER 217 243 243 SER SER A . n 
A 1 218 GLN 218 244 244 GLN GLN A . n 
A 1 219 THR 219 245 245 THR THR A . n 
A 1 220 GLY 220 246 246 GLY GLY A . n 
A 1 221 ILE 221 247 247 ILE ILE A . n 
A 1 222 ASN 222 248 248 ASN ASN A . n 
A 1 223 MET 223 249 249 MET MET A . n 
A 1 224 LYS 224 250 250 LYS LYS A . n 
A 1 225 THR 225 251 251 THR THR A . n 
A 1 226 ALA 226 252 252 ALA ALA A . n 
A 1 227 ALA 227 253 253 ALA ALA A . n 
A 1 228 SER 228 254 254 SER SER A . n 
A 1 229 ILE 229 255 255 ILE ILE A . n 
A 1 230 ASN 230 256 256 ASN ASN A . n 
A 1 231 GLY 231 257 257 GLY GLY A . n 
A 1 232 ARG 232 258 258 ARG ARG A . n 
A 1 233 MET 233 259 259 MET MET A . n 
A 1 234 MET 234 260 260 MET MET A . n 
A 1 235 ALA 235 261 261 ALA ALA A . n 
A 1 236 GLN 236 262 262 GLN GLN A . n 
A 1 237 THR 237 263 263 THR THR A . n 
A 1 238 ALA 238 264 264 ALA ALA A . n 
A 1 239 VAL 239 265 265 VAL VAL A . n 
A 1 240 THR 240 266 266 THR THR A . n 
A 1 241 LEU 241 267 267 LEU LEU A . n 
A 1 242 GLN 242 268 268 GLN GLN A . n 
A 1 243 MET 243 269 269 MET MET A . n 
A 1 244 ASN 244 270 270 ASN ASN A . n 
A 1 245 THR 245 271 271 THR THR A . n 
A 1 246 VAL 246 272 272 VAL VAL A . n 
A 1 247 THR 247 273 273 THR THR A . n 
A 1 248 ILE 248 274 274 ILE ILE A . n 
A 1 249 PRO 249 275 275 PRO PRO A . n 
A 1 250 GLN 250 276 276 GLN GLN A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   301 103 HOH HOH A . 
B 2 HOH 2   302 63  HOH HOH A . 
B 2 HOH 3   303 85  HOH HOH A . 
B 2 HOH 4   304 91  HOH HOH A . 
B 2 HOH 5   305 43  HOH HOH A . 
B 2 HOH 6   306 82  HOH HOH A . 
B 2 HOH 7   307 37  HOH HOH A . 
B 2 HOH 8   308 30  HOH HOH A . 
B 2 HOH 9   309 28  HOH HOH A . 
B 2 HOH 10  310 75  HOH HOH A . 
B 2 HOH 11  311 95  HOH HOH A . 
B 2 HOH 12  312 87  HOH HOH A . 
B 2 HOH 13  313 70  HOH HOH A . 
B 2 HOH 14  314 104 HOH HOH A . 
B 2 HOH 15  315 32  HOH HOH A . 
B 2 HOH 16  316 26  HOH HOH A . 
B 2 HOH 17  317 47  HOH HOH A . 
B 2 HOH 18  318 29  HOH HOH A . 
B 2 HOH 19  319 93  HOH HOH A . 
B 2 HOH 20  320 12  HOH HOH A . 
B 2 HOH 21  321 34  HOH HOH A . 
B 2 HOH 22  322 5   HOH HOH A . 
B 2 HOH 23  323 44  HOH HOH A . 
B 2 HOH 24  324 16  HOH HOH A . 
B 2 HOH 25  325 31  HOH HOH A . 
B 2 HOH 26  326 14  HOH HOH A . 
B 2 HOH 27  327 105 HOH HOH A . 
B 2 HOH 28  328 66  HOH HOH A . 
B 2 HOH 29  329 102 HOH HOH A . 
B 2 HOH 30  330 11  HOH HOH A . 
B 2 HOH 31  331 22  HOH HOH A . 
B 2 HOH 32  332 15  HOH HOH A . 
B 2 HOH 33  333 24  HOH HOH A . 
B 2 HOH 34  334 51  HOH HOH A . 
B 2 HOH 35  335 49  HOH HOH A . 
B 2 HOH 36  336 99  HOH HOH A . 
B 2 HOH 37  337 23  HOH HOH A . 
B 2 HOH 38  338 4   HOH HOH A . 
B 2 HOH 39  339 53  HOH HOH A . 
B 2 HOH 40  340 8   HOH HOH A . 
B 2 HOH 41  341 46  HOH HOH A . 
B 2 HOH 42  342 73  HOH HOH A . 
B 2 HOH 43  343 52  HOH HOH A . 
B 2 HOH 44  344 13  HOH HOH A . 
B 2 HOH 45  345 90  HOH HOH A . 
B 2 HOH 46  346 50  HOH HOH A . 
B 2 HOH 47  347 69  HOH HOH A . 
B 2 HOH 48  348 40  HOH HOH A . 
B 2 HOH 49  349 71  HOH HOH A . 
B 2 HOH 50  350 101 HOH HOH A . 
B 2 HOH 51  351 72  HOH HOH A . 
B 2 HOH 52  352 59  HOH HOH A . 
B 2 HOH 53  353 21  HOH HOH A . 
B 2 HOH 54  354 74  HOH HOH A . 
B 2 HOH 55  355 38  HOH HOH A . 
B 2 HOH 56  356 48  HOH HOH A . 
B 2 HOH 57  357 45  HOH HOH A . 
B 2 HOH 58  358 2   HOH HOH A . 
B 2 HOH 59  359 36  HOH HOH A . 
B 2 HOH 60  360 6   HOH HOH A . 
B 2 HOH 61  361 7   HOH HOH A . 
B 2 HOH 62  362 33  HOH HOH A . 
B 2 HOH 63  363 62  HOH HOH A . 
B 2 HOH 64  364 67  HOH HOH A . 
B 2 HOH 65  365 9   HOH HOH A . 
B 2 HOH 66  366 3   HOH HOH A . 
B 2 HOH 67  367 98  HOH HOH A . 
B 2 HOH 68  368 25  HOH HOH A . 
B 2 HOH 69  369 19  HOH HOH A . 
B 2 HOH 70  370 10  HOH HOH A . 
B 2 HOH 71  371 35  HOH HOH A . 
B 2 HOH 72  372 68  HOH HOH A . 
B 2 HOH 73  373 65  HOH HOH A . 
B 2 HOH 74  374 80  HOH HOH A . 
B 2 HOH 75  375 64  HOH HOH A . 
B 2 HOH 76  376 78  HOH HOH A . 
B 2 HOH 77  377 61  HOH HOH A . 
B 2 HOH 78  378 89  HOH HOH A . 
B 2 HOH 79  379 97  HOH HOH A . 
B 2 HOH 80  380 1   HOH HOH A . 
B 2 HOH 81  381 42  HOH HOH A . 
B 2 HOH 82  382 17  HOH HOH A . 
B 2 HOH 83  383 84  HOH HOH A . 
B 2 HOH 84  384 86  HOH HOH A . 
B 2 HOH 85  385 20  HOH HOH A . 
B 2 HOH 86  386 55  HOH HOH A . 
B 2 HOH 87  387 57  HOH HOH A . 
B 2 HOH 88  388 54  HOH HOH A . 
B 2 HOH 89  389 79  HOH HOH A . 
B 2 HOH 90  390 88  HOH HOH A . 
B 2 HOH 91  391 92  HOH HOH A . 
B 2 HOH 92  392 81  HOH HOH A . 
B 2 HOH 93  393 41  HOH HOH A . 
B 2 HOH 94  394 58  HOH HOH A . 
B 2 HOH 95  395 56  HOH HOH A . 
B 2 HOH 96  396 96  HOH HOH A . 
B 2 HOH 97  397 77  HOH HOH A . 
B 2 HOH 98  398 60  HOH HOH A . 
B 2 HOH 99  399 39  HOH HOH A . 
B 2 HOH 100 400 76  HOH HOH A . 
B 2 HOH 101 401 83  HOH HOH A . 
B 2 HOH 102 402 94  HOH HOH A . 
B 2 HOH 103 403 100 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0258 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP ? ? ? .        4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8X1L 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     69.060 
_cell.length_a_esd                 ? 
_cell.length_b                     69.060 
_cell.length_b_esd                 ? 
_cell.length_c                     178.350 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8X1L 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                91 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 41 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8X1L 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             4.13 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          70.23 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M sodium citrate pH 4.4, 3 M sodium chloride' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            295 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-11-17 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PAL/PLS BEAMLINE 5C (4A)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   '5C (4A)' 
_diffrn_source.pdbx_synchrotron_site       PAL/PLS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8X1L 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               29.877 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     30097 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                25.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          31.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.06 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.0 
_reflns_shell.d_res_low                                     2.05 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2183 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  1 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.000 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            0.000 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            -0.001 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               39.659 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.955 
_refine.correlation_coeff_Fo_to_Fc_free          0.948 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8X1L 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.000 
_refine.ls_d_res_low                             29.877 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     30097 
_refine.ls_number_reflns_R_free                  1484 
_refine.ls_number_reflns_R_work                  28613 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.924 
_refine.ls_percent_reflns_R_free                 4.931 
_refine.ls_R_factor_all                          0.228 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2510 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2265 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.126 
_refine.pdbx_overall_ESU_R_Free                  0.123 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             4.016 
_refine.overall_SU_ML                            0.105 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.000 
_refine_hist.d_res_low                        29.877 
_refine_hist.number_atoms_solvent             103 
_refine_hist.number_atoms_total               1655 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1552 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.012  0.013  1574 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  1481 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.813  1.632  2147 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.353  1.567  3432 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 7.293  5.000  215  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 36.772 24.727 55   ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.239 15.000 250  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 17.883 15.000 4    ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.085  0.200  240  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  1773 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  291  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.198  0.200  295  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.184  0.200  1332 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.153  0.200  777  ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.079  0.200  783  ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.194  0.200  76   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.062  0.200  1    ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.010  0.200  3    ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.236  0.200  28   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.113  0.200  3    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 4.273  4.148  863  ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 4.264  4.145  862  ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.149  6.184  1077 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.150  6.186  1078 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 4.472  4.440  710  ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 4.381  4.429  708  ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 6.400  6.504  1070 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 6.389  6.501  1070 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 7.326  50.888 1680 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 7.347  50.863 1676 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.000 2.052  . . 119 2064 99.9542  . . . . 0.327 . . . . . . . . . . . 0.334 
'X-RAY DIFFRACTION' 2.052 2.108  . . 86  2016 99.9049  . . . . 0.302 . . . . . . . . . . . 0.342 
'X-RAY DIFFRACTION' 2.108 2.169  . . 91  1999 99.9522  . . . . 0.316 . . . . . . . . . . . 0.350 
'X-RAY DIFFRACTION' 2.169 2.236  . . 91  1916 100.0000 . . . . 0.327 . . . . . . . . . . . 0.373 
'X-RAY DIFFRACTION' 2.236 2.309  . . 104 1836 100.0000 . . . . 0.312 . . . . . . . . . . . 0.362 
'X-RAY DIFFRACTION' 2.309 2.390  . . 93  1804 100.0000 . . . . 0.287 . . . . . . . . . . . 0.334 
'X-RAY DIFFRACTION' 2.390 2.480  . . 97  1729 100.0000 . . . . 0.269 . . . . . . . . . . . 0.303 
'X-RAY DIFFRACTION' 2.480 2.581  . . 80  1675 100.0000 . . . . 0.277 . . . . . . . . . . . 0.348 
'X-RAY DIFFRACTION' 2.581 2.696  . . 84  1602 100.0000 . . . . 0.271 . . . . . . . . . . . 0.317 
'X-RAY DIFFRACTION' 2.696 2.827  . . 87  1538 100.0000 . . . . 0.265 . . . . . . . . . . . 0.288 
'X-RAY DIFFRACTION' 2.827 2.980  . . 81  1486 99.9362  . . . . 0.261 . . . . . . . . . . . 0.314 
'X-RAY DIFFRACTION' 2.980 3.160  . . 71  1408 100.0000 . . . . 0.252 . . . . . . . . . . . 0.258 
'X-RAY DIFFRACTION' 3.160 3.378  . . 75  1311 100.0000 . . . . 0.246 . . . . . . . . . . . 0.295 
'X-RAY DIFFRACTION' 3.378 3.648  . . 72  1235 100.0000 . . . . 0.218 . . . . . . . . . . . 0.272 
'X-RAY DIFFRACTION' 3.648 3.995  . . 53  1140 99.9163  . . . . 0.178 . . . . . . . . . . . 0.206 
'X-RAY DIFFRACTION' 3.995 4.465  . . 54  1062 100.0000 . . . . 0.167 . . . . . . . . . . . 0.133 
'X-RAY DIFFRACTION' 4.465 5.152  . . 50  934  100.0000 . . . . 0.148 . . . . . . . . . . . 0.179 
'X-RAY DIFFRACTION' 5.152 6.301  . . 43  813  100.0000 . . . . 0.182 . . . . . . . . . . . 0.225 
'X-RAY DIFFRACTION' 6.301 8.874  . . 28  657  100.0000 . . . . 0.185 . . . . . . . . . . . 0.144 
'X-RAY DIFFRACTION' 8.874 29.877 . . 25  388  96.0465  . . . . 0.224 . . . . . . . . . . . 0.247 
# 
_struct.entry_id                     8X1L 
_struct.title                        'Crystal structure of S96C/L132C mutant of FfIBP' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8X1L 
_struct_keywords.text            
'ice-binding protein, Flavobacterium frigoris PS1, ice recrystallization, thermal hysteresis, ANTIFREEZE PROTEIN' 
_struct_keywords.pdbx_keywords   'ANTIFREEZE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    IBP_FLAFP 
_struct_ref.pdbx_db_accession          H7FWB6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SLSVANSTYETTALNSQKSSTDQPNSGSKSGQTLDLVNLGVAANFAILSKTGITDVYKSAITGDVGASPITGAAILLKCD
EVTGTIFSVDAAGPACKITDASRLTTAVGDMQIAYDNAAGRLNPDFLNLGAGTIGGKTLTPGLYKWTSTLNIPTDITISG
SSTDVWIFQVAGNLNMSSAVRITLAGGAQAKNIFWQTAGAVTLGSTSHFEGNILSQTGINMKTAASINGRMMAQTAVTLQ
MNTVTIPQ
;
_struct_ref.pdbx_align_begin           29 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8X1L 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 250 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             H7FWB6 
_struct_ref_seq.db_align_beg                  29 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  276 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       29 
_struct_ref_seq.pdbx_auth_seq_align_end       276 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8X1L HIS A 1   ? UNP H7FWB6 ?   ?   'expression tag'      27  1 
1 8X1L MET A 2   ? UNP H7FWB6 ?   ?   'expression tag'      28  2 
1 8X1L CYS A 70  ? UNP H7FWB6 SER 96  'engineered mutation' 96  3 
1 8X1L CYS A 106 ? UNP H7FWB6 LEU 132 'engineered mutation' 132 4 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 0    ? 
1 MORE         0    ? 
1 'SSA (A^2)'  8330 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 LEU A 41  ? ALA A 45  ? LEU A 67  ALA A 71  5 ? 5  
HELX_P HELX_P2 AA2 THR A 73  ? ILE A 77  ? THR A 99  ILE A 103 5 ? 5  
HELX_P HELX_P3 AA3 LYS A 80  ? ASP A 82  ? LYS A 106 ASP A 108 5 ? 3  
HELX_P HELX_P4 AA4 ASP A 102 ? GLY A 122 ? ASP A 128 GLY A 148 1 ? 21 
HELX_P HELX_P5 AA5 LEU A 131 ? THR A 135 ? LEU A 157 THR A 161 5 ? 5  
HELX_P HELX_P6 AA6 GLN A 191 ? LYS A 193 ? GLN A 217 LYS A 219 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            81 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            98 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             107 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             124 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.094 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       81 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      98 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        107 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       124 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 TYR 59 A . ? TYR 85 A LYS 60 A ? LYS 86 A 1 2.72  
2 CYS 70 A . ? CYS 96 A PRO 71 A ? PRO 97 A 1 11.21 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 6  ? 
AA3 ? 5  ? 
AA4 ? 3  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel 
AA1 2 3  ? parallel 
AA1 3 4  ? parallel 
AA1 4 5  ? parallel 
AA1 5 6  ? parallel 
AA1 6 7  ? parallel 
AA1 7 8  ? parallel 
AA1 8 9  ? parallel 
AA1 9 10 ? parallel 
AA2 1 2  ? parallel 
AA2 2 3  ? parallel 
AA2 3 4  ? parallel 
AA2 4 5  ? parallel 
AA2 5 6  ? parallel 
AA3 1 2  ? parallel 
AA3 2 3  ? parallel 
AA3 3 4  ? parallel 
AA3 4 5  ? parallel 
AA4 1 2  ? parallel 
AA4 2 3  ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  ILE A 100 ? THR A 101 ? ILE A 126 THR A 127 
AA1 2  ILE A 88  ? SER A 90  ? ILE A 114 SER A 116 
AA1 3  ASP A 66  ? ALA A 69  ? ASP A 92  ALA A 95  
AA1 4  PHE A 47  ? SER A 51  ? PHE A 73  SER A 77  
AA1 5  MET A 233 ? ALA A 235 ? MET A 259 ALA A 261 
AA1 6  ASN A 214 ? SER A 217 ? ASN A 240 SER A 243 
AA1 7  ILE A 195 ? THR A 199 ? ILE A 221 THR A 225 
AA1 8  TRP A 168 ? VAL A 172 ? TRP A 194 VAL A 198 
AA1 9  GLY A 144 ? TRP A 148 ? GLY A 170 TRP A 174 
AA1 10 PHE A 128 ? LEU A 129 ? PHE A 154 LEU A 155 
AA2 1  ILE A 55  ? VAL A 58  ? ILE A 81  VAL A 84  
AA2 2  VAL A 239 ? GLN A 242 ? VAL A 265 GLN A 268 
AA2 3  ILE A 221 ? MET A 223 ? ILE A 247 MET A 249 
AA2 4  VAL A 203 ? LEU A 205 ? VAL A 229 LEU A 231 
AA2 5  LEU A 176 ? MET A 178 ? LEU A 202 MET A 204 
AA2 6  LEU A 152 ? ILE A 154 ? LEU A 178 ILE A 180 
AA3 1  VAL A 84  ? THR A 85  ? VAL A 110 THR A 111 
AA3 2  ALA A 62  ? THR A 64  ? ALA A 88  THR A 90  
AA3 3  THR A 245 ? THR A 247 ? THR A 271 THR A 273 
AA3 4  SER A 228 ? ASN A 230 ? SER A 254 ASN A 256 
AA3 5  HIS A 210 ? GLU A 212 ? HIS A 236 GLU A 238 
AA4 1  THR A 140 ? LEU A 141 ? THR A 166 LEU A 167 
AA4 2  ILE A 158 ? SER A 161 ? ILE A 184 SER A 187 
AA4 3  ILE A 184 ? ALA A 187 ? ILE A 210 ALA A 213 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  O ILE A 100 ? O ILE A 126 N ILE A 88  ? N ILE A 114 
AA1 2 3  O PHE A 89  ? O PHE A 115 N VAL A 67  ? N VAL A 93  
AA1 3 4  O ASP A 66  ? O ASP A 92  N ALA A 48  ? N ALA A 74  
AA1 4 5  N ALA A 48  ? N ALA A 74  O MET A 233 ? O MET A 259 
AA1 5 6  O MET A 234 ? O MET A 260 N SER A 217 ? N SER A 243 
AA1 6 7  O LEU A 216 ? O LEU A 242 N TRP A 197 ? N TRP A 223 
AA1 7 8  O GLN A 198 ? O GLN A 224 N PHE A 170 ? N PHE A 196 
AA1 8 9  O GLN A 171 ? O GLN A 197 N TYR A 146 ? N TYR A 172 
AA1 9 10 O LYS A 147 ? O LYS A 173 N PHE A 128 ? N PHE A 154 
AA2 1 2  N THR A 56  ? N THR A 82  O VAL A 239 ? O VAL A 265 
AA2 2 3  O THR A 240 ? O THR A 266 N MET A 223 ? N MET A 249 
AA2 3 4  O ASN A 222 ? O ASN A 248 N VAL A 203 ? N VAL A 229 
AA2 4 5  O THR A 204 ? O THR A 230 N LEU A 176 ? N LEU A 202 
AA2 5 6  O ASN A 177 ? O ASN A 203 N LEU A 152 ? N LEU A 178 
AA3 1 2  O THR A 85  ? O THR A 111 N ILE A 63  ? N ILE A 89  
AA3 2 3  N THR A 64  ? N THR A 90  O VAL A 246 ? O VAL A 272 
AA3 3 4  O THR A 247 ? O THR A 273 N ILE A 229 ? N ILE A 255 
AA3 4 5  O ASN A 230 ? O ASN A 256 N PHE A 211 ? N PHE A 237 
AA4 1 2  N LEU A 141 ? N LEU A 167 O THR A 159 ? O THR A 185 
AA4 2 3  N ILE A 160 ? N ILE A 186 O THR A 185 ? O THR A 211 
# 
_pdbx_entry_details.entry_id                   8X1L 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              258 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              258 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH2 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              258 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                117.15 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            -3.15 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 CYS A 96  ? ? -177.19 135.22  
2 1 ASP A 128 ? ? -150.78 88.60   
3 1 ASN A 151 ? ? 70.42   57.59   
4 1 SER A 176 ? ? -125.45 -164.79 
5 1 ALA A 207 ? ? 70.69   -1.92   
6 1 THR A 245 ? ? -120.42 -120.97 
7 1 THR A 251 ? ? -33.00  112.32  
8 1 THR A 263 ? ? -115.27 -116.51 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     400 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   B 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       403 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.07 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A HIS 27 ? A HIS 1  
2  1 Y 1 A MET 28 ? A MET 2  
3  1 Y 1 A SER 29 ? A SER 3  
4  1 Y 1 A LEU 30 ? A LEU 4  
5  1 Y 1 A SER 31 ? A SER 5  
6  1 Y 1 A VAL 32 ? A VAL 6  
7  1 Y 1 A ALA 33 ? A ALA 7  
8  1 Y 1 A ASN 34 ? A ASN 8  
9  1 Y 1 A SER 35 ? A SER 9  
10 1 Y 1 A THR 36 ? A THR 10 
11 1 Y 1 A TYR 37 ? A TYR 11 
12 1 Y 1 A GLU 38 ? A GLU 12 
13 1 Y 1 A THR 39 ? A THR 13 
14 1 Y 1 A THR 40 ? A THR 14 
15 1 Y 1 A ALA 41 ? A ALA 15 
16 1 Y 1 A LEU 42 ? A LEU 16 
17 1 Y 1 A ASN 43 ? A ASN 17 
18 1 Y 1 A SER 44 ? A SER 18 
19 1 Y 1 A GLN 45 ? A GLN 19 
20 1 Y 1 A LYS 46 ? A LYS 20 
21 1 Y 1 A SER 47 ? A SER 21 
22 1 Y 1 A SER 48 ? A SER 22 
23 1 Y 1 A THR 49 ? A THR 23 
24 1 Y 1 A ASP 50 ? A ASP 24 
25 1 Y 1 A GLN 51 ? A GLN 25 
26 1 Y 1 A PRO 52 ? A PRO 26 
27 1 Y 1 A ASN 53 ? A ASN 27 
28 1 Y 1 A SER 54 ? A SER 28 
29 1 Y 1 A GLY 55 ? A GLY 29 
30 1 Y 1 A SER 56 ? A SER 30 
31 1 Y 1 A LYS 57 ? A LYS 31 
32 1 Y 1 A SER 58 ? A SER 32 
33 1 Y 1 A GLY 59 ? A GLY 33 
34 1 Y 1 A GLN 60 ? A GLN 34 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                'Korea, Republic Of' 
_pdbx_audit_support.grant_number           'KIMST 20200610' 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4NU2 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8X1L 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014480 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014480 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005607 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H 1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
N 7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O 8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
S 16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 1.056   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . THR A 1 35  ? -1.568  -37.496 -18.379 1.000 78.644 ? 61  THR A N   1 ? 
ATOM   2    C CA  . THR A 1 35  ? -1.754  -38.983 -18.214 1.000 85.101 ? 61  THR A CA  1 ? 
ATOM   3    C C   . THR A 1 35  ? -2.921  -39.302 -17.250 1.000 72.833 ? 61  THR A C   1 ? 
ATOM   4    O O   . THR A 1 35  ? -3.226  -40.506 -17.104 1.000 73.428 ? 61  THR A O   1 ? 
ATOM   5    C CB  . THR A 1 35  ? -0.450  -39.686 -17.774 1.000 88.378 ? 61  THR A CB  1 ? 
ATOM   6    O OG1 . THR A 1 35  ? 0.673   -38.934 -18.224 1.000 88.906 ? 61  THR A OG1 1 ? 
ATOM   7    C CG2 . THR A 1 35  ? -0.296  -41.099 -18.307 1.000 83.239 ? 61  THR A CG2 1 ? 
ATOM   8    N N   . LEU A 1 36  ? -3.570  -38.317 -16.609 1.000 62.224 ? 62  LEU A N   1 ? 
ATOM   9    C CA  . LEU A 1 36  ? -4.746  -38.594 -15.729 1.000 58.230 ? 62  LEU A CA  1 ? 
ATOM   10   C C   . LEU A 1 36  ? -5.996  -38.782 -16.616 1.000 48.947 ? 62  LEU A C   1 ? 
ATOM   11   O O   . LEU A 1 36  ? -6.351  -37.864 -17.381 1.000 48.727 ? 62  LEU A O   1 ? 
ATOM   12   C CB  . LEU A 1 36  ? -4.897  -37.483 -14.680 1.000 59.072 ? 62  LEU A CB  1 ? 
ATOM   13   C CG  . LEU A 1 36  ? -5.854  -37.762 -13.515 1.000 52.808 ? 62  LEU A CG  1 ? 
ATOM   14   C CD1 . LEU A 1 36  ? -5.511  -39.024 -12.730 1.000 53.487 ? 62  LEU A CD1 1 ? 
ATOM   15   C CD2 . LEU A 1 36  ? -5.902  -36.586 -12.569 1.000 52.812 ? 62  LEU A CD2 1 ? 
ATOM   16   N N   . ASP A 1 37  ? -6.582  -39.979 -16.575 1.000 43.319 ? 63  ASP A N   1 ? 
ATOM   17   C CA  . ASP A 1 37  ? -7.814  -40.372 -17.323 1.000 52.328 ? 63  ASP A CA  1 ? 
ATOM   18   C C   . ASP A 1 37  ? -9.041  -39.595 -16.819 1.000 51.891 ? 63  ASP A C   1 ? 
ATOM   19   O O   . ASP A 1 37  ? -9.174  -39.408 -15.588 1.000 48.468 ? 63  ASP A O   1 ? 
ATOM   20   C CB  . ASP A 1 37  ? -8.162  -41.862 -17.175 1.000 54.094 ? 63  ASP A CB  1 ? 
ATOM   21   C CG  . ASP A 1 37  ? -7.260  -42.836 -17.936 1.000 63.592 ? 63  ASP A CG  1 ? 
ATOM   22   O OD1 . ASP A 1 37  ? -6.464  -42.379 -18.786 1.000 58.729 ? 63  ASP A OD1 1 ? 
ATOM   23   O OD2 . ASP A 1 37  ? -7.352  -44.057 -17.656 1.000 65.928 ? 63  ASP A OD2 1 ? 
ATOM   24   N N   . LEU A 1 38  ? -9.914  -39.203 -17.754 1.000 50.005 ? 64  LEU A N   1 ? 
ATOM   25   C CA  . LEU A 1 38  ? -11.235 -38.594 -17.473 1.000 50.995 ? 64  LEU A CA  1 ? 
ATOM   26   C C   . LEU A 1 38  ? -12.043 -39.529 -16.579 1.000 41.910 ? 64  LEU A C   1 ? 
ATOM   27   O O   . LEU A 1 38  ? -11.884 -40.749 -16.655 1.000 43.097 ? 64  LEU A O   1 ? 
ATOM   28   C CB  . LEU A 1 38  ? -11.989 -38.336 -18.783 1.000 55.479 ? 64  LEU A CB  1 ? 
ATOM   29   C CG  . LEU A 1 38  ? -11.363 -37.274 -19.683 1.000 64.696 ? 64  LEU A CG  1 ? 
ATOM   30   C CD1 . LEU A 1 38  ? -12.165 -37.106 -20.967 1.000 66.689 ? 64  LEU A CD1 1 ? 
ATOM   31   C CD2 . LEU A 1 38  ? -11.250 -35.942 -18.961 1.000 64.188 ? 64  LEU A CD2 1 ? 
ATOM   32   N N   . VAL A 1 39  ? -12.917 -38.958 -15.773 1.000 42.340 ? 65  VAL A N   1 ? 
ATOM   33   C CA  . VAL A 1 39  ? -13.986 -39.726 -15.090 1.000 44.858 ? 65  VAL A CA  1 ? 
ATOM   34   C C   . VAL A 1 39  ? -15.173 -39.844 -16.061 1.000 43.764 ? 65  VAL A C   1 ? 
ATOM   35   O O   . VAL A 1 39  ? -15.803 -38.844 -16.344 1.000 42.734 ? 65  VAL A O   1 ? 
ATOM   36   C CB  . VAL A 1 39  ? -14.391 -39.083 -13.754 1.000 40.244 ? 65  VAL A CB  1 ? 
ATOM   37   C CG1 . VAL A 1 39  ? -15.546 -39.822 -13.120 1.000 37.457 ? 65  VAL A CG1 1 ? 
ATOM   38   C CG2 . VAL A 1 39  ? -13.226 -39.002 -12.785 1.000 41.335 ? 65  VAL A CG2 1 ? 
ATOM   39   N N   . ASN A 1 40  ? -15.497 -41.074 -16.441 1.000 39.667 ? 66  ASN A N   1 ? 
ATOM   40   C CA  . ASN A 1 40  ? -16.617 -41.438 -17.344 1.000 43.877 ? 66  ASN A CA  1 ? 
ATOM   41   C C   . ASN A 1 40  ? -17.936 -41.338 -16.577 1.000 38.914 ? 66  ASN A C   1 ? 
ATOM   42   O O   . ASN A 1 40  ? -18.157 -42.128 -15.619 1.000 41.388 ? 66  ASN A O   1 ? 
ATOM   43   C CB  . ASN A 1 40  ? -16.457 -42.850 -17.921 1.000 46.605 ? 66  ASN A CB  1 ? 
ATOM   44   C CG  . ASN A 1 40  ? -17.412 -43.139 -19.057 1.000 53.478 ? 66  ASN A CG  1 ? 
ATOM   45   O OD1 . ASN A 1 40  ? -18.448 -42.497 -19.196 1.000 53.030 ? 66  ASN A OD1 1 ? 
ATOM   46   N ND2 . ASN A 1 40  ? -17.075 -44.123 -19.870 1.000 60.644 ? 66  ASN A ND2 1 ? 
ATOM   47   N N   . LEU A 1 41  ? -18.793 -40.429 -17.016 1.000 34.803 ? 67  LEU A N   1 ? 
ATOM   48   C CA  . LEU A 1 41  ? -20.113 -40.154 -16.374 1.000 35.395 ? 67  LEU A CA  1 ? 
ATOM   49   C C   . LEU A 1 41  ? -21.236 -40.956 -17.029 1.000 35.456 ? 67  LEU A C   1 ? 
ATOM   50   O O   . LEU A 1 41  ? -22.443 -40.874 -16.523 1.000 37.076 ? 67  LEU A O   1 ? 
ATOM   51   C CB  . LEU A 1 41  ? -20.403 -38.657 -16.474 1.000 31.450 ? 67  LEU A CB  1 ? 
ATOM   52   C CG  . LEU A 1 41  ? -19.433 -37.743 -15.757 1.000 35.626 ? 67  LEU A CG  1 ? 
ATOM   53   C CD1 . LEU A 1 41  ? -19.826 -36.321 -16.042 1.000 33.688 ? 67  LEU A CD1 1 ? 
ATOM   54   C CD2 . LEU A 1 41  ? -19.374 -38.016 -14.252 1.000 38.433 ? 67  LEU A CD2 1 ? 
ATOM   55   N N   . GLY A 1 42  ? -20.932 -41.722 -18.086 1.000 36.833 ? 68  GLY A N   1 ? 
ATOM   56   C CA  . GLY A 1 42  ? -21.973 -42.422 -18.869 1.000 37.250 ? 68  GLY A CA  1 ? 
ATOM   57   C C   . GLY A 1 42  ? -23.188 -41.552 -19.105 1.000 37.346 ? 68  GLY A C   1 ? 
ATOM   58   O O   . GLY A 1 42  ? -23.023 -40.340 -19.429 1.000 35.713 ? 68  GLY A O   1 ? 
ATOM   59   N N   . VAL A 1 43  ? -24.373 -42.093 -18.870 1.000 38.962 ? 69  VAL A N   1 ? 
ATOM   60   C CA  . VAL A 1 43  ? -25.662 -41.375 -19.129 1.000 34.485 ? 69  VAL A CA  1 ? 
ATOM   61   C C   . VAL A 1 43  ? -25.770 -40.129 -18.247 1.000 33.877 ? 69  VAL A C   1 ? 
ATOM   62   O O   . VAL A 1 43  ? -26.501 -39.219 -18.647 1.000 31.657 ? 69  VAL A O   1 ? 
ATOM   63   C CB  . VAL A 1 43  ? -26.849 -42.352 -19.005 1.000 40.031 ? 69  VAL A CB  1 ? 
ATOM   64   C CG1 . VAL A 1 43  ? -28.214 -41.709 -19.068 1.000 40.607 ? 69  VAL A CG1 1 ? 
ATOM   65   C CG2 . VAL A 1 43  ? -26.733 -43.450 -20.061 1.000 40.596 ? 69  VAL A CG2 1 ? 
ATOM   66   N N   . ALA A 1 44  ? -25.090 -40.063 -17.096 1.000 34.555 ? 70  ALA A N   1 ? 
ATOM   67   C CA  . ALA A 1 44  ? -25.202 -38.917 -16.162 1.000 33.133 ? 70  ALA A CA  1 ? 
ATOM   68   C C   . ALA A 1 44  ? -24.637 -37.643 -16.800 1.000 29.670 ? 70  ALA A C   1 ? 
ATOM   69   O O   . ALA A 1 44  ? -25.068 -36.553 -16.362 1.000 30.337 ? 70  ALA A O   1 ? 
ATOM   70   C CB  . ALA A 1 44  ? -24.560 -39.205 -14.812 1.000 33.131 ? 70  ALA A CB  1 ? 
ATOM   71   N N   . ALA A 1 45  ? -23.720 -37.789 -17.774 1.000 34.409 ? 71  ALA A N   1 ? 
ATOM   72   C CA  . ALA A 1 45  ? -23.188 -36.698 -18.626 1.000 32.299 ? 71  ALA A CA  1 ? 
ATOM   73   C C   . ALA A 1 45  ? -24.317 -35.859 -19.221 1.000 32.613 ? 71  ALA A C   1 ? 
ATOM   74   O O   . ALA A 1 45  ? -24.114 -34.646 -19.429 1.000 30.738 ? 71  ALA A O   1 ? 
ATOM   75   C CB  . ALA A 1 45  ? -22.344 -37.270 -19.727 1.000 32.892 ? 71  ALA A CB  1 ? 
ATOM   76   N N   . ASN A 1 46  ? -25.485 -36.438 -19.457 1.000 32.001 ? 72  ASN A N   1 ? 
ATOM   77   C CA  . ASN A 1 46  ? -26.608 -35.705 -20.107 1.000 36.342 ? 72  ASN A CA  1 ? 
ATOM   78   C C   . ASN A 1 46  ? -27.303 -34.715 -19.143 1.000 40.225 ? 72  ASN A C   1 ? 
ATOM   79   O O   . ASN A 1 46  ? -28.172 -33.969 -19.598 1.000 41.400 ? 72  ASN A O   1 ? 
ATOM   80   C CB  . ASN A 1 46  ? -27.532 -36.715 -20.780 1.000 38.208 ? 72  ASN A CB  1 ? 
ATOM   81   C CG  . ASN A 1 46  ? -26.825 -37.486 -21.892 1.000 37.715 ? 72  ASN A CG  1 ? 
ATOM   82   O OD1 . ASN A 1 46  ? -26.165 -36.927 -22.748 1.000 36.751 ? 72  ASN A OD1 1 ? 
ATOM   83   N ND2 . ASN A 1 46  ? -26.861 -38.801 -21.848 1.000 42.692 ? 72  ASN A ND2 1 ? 
ATOM   84   N N   . PHE A 1 47  ? -26.911 -34.632 -17.866 1.000 38.057 ? 73  PHE A N   1 ? 
ATOM   85   C CA  . PHE A 1 47  ? -27.652 -33.883 -16.813 1.000 31.297 ? 73  PHE A CA  1 ? 
ATOM   86   C C   . PHE A 1 47  ? -26.797 -32.746 -16.277 1.000 33.036 ? 73  PHE A C   1 ? 
ATOM   87   O O   . PHE A 1 47  ? -25.559 -32.933 -15.986 1.000 34.483 ? 73  PHE A O   1 ? 
ATOM   88   C CB  . PHE A 1 47  ? -28.068 -34.825 -15.674 1.000 31.734 ? 73  PHE A CB  1 ? 
ATOM   89   C CG  . PHE A 1 47  ? -29.096 -35.841 -16.083 1.000 32.164 ? 73  PHE A CG  1 ? 
ATOM   90   C CD1 . PHE A 1 47  ? -28.729 -36.982 -16.777 1.000 33.446 ? 73  PHE A CD1 1 ? 
ATOM   91   C CD2 . PHE A 1 47  ? -30.453 -35.598 -15.872 1.000 33.104 ? 73  PHE A CD2 1 ? 
ATOM   92   C CE1 . PHE A 1 47  ? -29.679 -37.889 -17.211 1.000 34.441 ? 73  PHE A CE1 1 ? 
ATOM   93   C CE2 . PHE A 1 47  ? -31.397 -36.506 -16.307 1.000 31.606 ? 73  PHE A CE2 1 ? 
ATOM   94   C CZ  . PHE A 1 47  ? -31.021 -37.654 -16.972 1.000 33.067 ? 73  PHE A CZ  1 ? 
ATOM   95   N N   . ALA A 1 48  ? -27.420 -31.579 -16.098 1.000 29.742 ? 74  ALA A N   1 ? 
ATOM   96   C CA  . ALA A 1 48  ? -26.829 -30.506 -15.281 1.000 29.590 ? 74  ALA A CA  1 ? 
ATOM   97   C C   . ALA A 1 48  ? -27.001 -30.829 -13.785 1.000 31.527 ? 74  ALA A C   1 ? 
ATOM   98   O O   . ALA A 1 48  ? -26.057 -30.646 -13.008 1.000 31.145 ? 74  ALA A O   1 ? 
ATOM   99   C CB  . ALA A 1 48  ? -27.471 -29.209 -15.665 1.000 30.821 ? 74  ALA A CB  1 ? 
ATOM   100  N N   . ILE A 1 49  ? -28.175 -31.337 -13.392 1.000 28.454 ? 75  ILE A N   1 ? 
ATOM   101  C CA  . ILE A 1 49  ? -28.508 -31.717 -11.999 1.000 28.217 ? 75  ILE A CA  1 ? 
ATOM   102  C C   . ILE A 1 49  ? -29.049 -33.155 -12.044 1.000 30.169 ? 75  ILE A C   1 ? 
ATOM   103  O O   . ILE A 1 49  ? -30.089 -33.498 -12.761 1.000 31.709 ? 75  ILE A O   1 ? 
ATOM   104  C CB  . ILE A 1 49  ? -29.493 -30.736 -11.376 1.000 34.299 ? 75  ILE A CB  1 ? 
ATOM   105  C CG1 . ILE A 1 49  ? -29.025 -29.284 -11.534 1.000 35.609 ? 75  ILE A CG1 1 ? 
ATOM   106  C CG2 . ILE A 1 49  ? -29.773 -31.102 -9.916  1.000 34.664 ? 75  ILE A CG2 1 ? 
ATOM   107  C CD1 . ILE A 1 49  ? -29.943 -28.279 -10.859 1.000 36.069 ? 75  ILE A CD1 1 ? 
ATOM   108  N N   . LEU A 1 50  ? -28.505 -33.972 -11.200 1.000 29.640 ? 76  LEU A N   1 ? 
ATOM   109  C CA  . LEU A 1 50  ? -29.023 -35.342 -10.995 1.000 31.963 ? 76  LEU A CA  1 ? 
ATOM   110  C C   . LEU A 1 50  ? -28.930 -35.635 -9.509  1.000 34.836 ? 76  LEU A C   1 ? 
ATOM   111  O O   . LEU A 1 50  ? -27.800 -35.515 -8.959  1.000 32.025 ? 76  LEU A O   1 ? 
ATOM   112  C CB  . LEU A 1 50  ? -28.189 -36.292 -11.826 1.000 33.628 ? 76  LEU A CB  1 ? 
ATOM   113  C CG  . LEU A 1 50  ? -28.638 -37.734 -11.816 1.000 36.618 ? 76  LEU A CG  1 ? 
ATOM   114  C CD1 . LEU A 1 50  ? -30.014 -37.874 -12.489 1.000 42.628 ? 76  LEU A CD1 1 ? 
ATOM   115  C CD2 . LEU A 1 50  ? -27.599 -38.572 -12.513 1.000 40.888 ? 76  LEU A CD2 1 ? 
ATOM   116  N N   . SER A 1 51  ? -30.066 -35.894 -8.835  1.000 35.174 ? 77  SER A N   1 ? 
ATOM   117  C CA  . SER A 1 51  ? -30.049 -36.331 -7.406  1.000 38.342 ? 77  SER A CA  1 ? 
ATOM   118  C C   . SER A 1 51  ? -30.790 -37.660 -7.134  1.000 44.768 ? 77  SER A C   1 ? 
ATOM   119  O O   . SER A 1 51  ? -31.402 -38.229 -8.052  1.000 43.136 ? 77  SER A O   1 ? 
ATOM   120  C CB  . SER A 1 51  ? -30.498 -35.246 -6.531  1.000 42.337 ? 77  SER A CB  1 ? 
ATOM   121  O OG  . SER A 1 51  ? -31.896 -35.182 -6.527  1.000 48.807 ? 77  SER A OG  1 ? 
ATOM   122  N N   . LYS A 1 52  ? -30.680 -38.192 -5.910  1.000 39.798 ? 78  LYS A N   1 ? 
ATOM   123  C CA  . LYS A 1 52  ? -31.451 -39.384 -5.533  1.000 41.779 ? 78  LYS A CA  1 ? 
ATOM   124  C C   . LYS A 1 52  ? -32.620 -39.041 -4.611  1.000 38.110 ? 78  LYS A C   1 ? 
ATOM   125  O O   . LYS A 1 52  ? -33.494 -39.899 -4.511  1.000 42.444 ? 78  LYS A O   1 ? 
ATOM   126  C CB  . LYS A 1 52  ? -30.574 -40.471 -4.929  1.000 45.546 ? 78  LYS A CB  1 ? 
ATOM   127  C CG  . LYS A 1 52  ? -29.465 -40.961 -5.835  1.000 46.287 ? 78  LYS A CG  1 ? 
ATOM   128  C CD  . LYS A 1 52  ? -28.736 -42.153 -5.253  1.000 46.592 ? 78  LYS A CD  1 ? 
ATOM   129  C CE  . LYS A 1 52  ? -29.634 -43.345 -5.040  1.000 50.056 ? 78  LYS A CE  1 ? 
ATOM   130  N NZ  . LYS A 1 52  ? -28.836 -44.574 -4.848  1.000 56.126 ? 78  LYS A NZ  1 ? 
ATOM   131  N N   . THR A 1 53  ? -32.632 -37.887 -3.955  1.000 38.329 ? 79  THR A N   1 ? 
ATOM   132  C CA  . THR A 1 53  ? -33.685 -37.541 -2.975  1.000 44.371 ? 79  THR A CA  1 ? 
ATOM   133  C C   . THR A 1 53  ? -34.306 -36.193 -3.341  1.000 43.329 ? 79  THR A C   1 ? 
ATOM   134  O O   . THR A 1 53  ? -35.111 -35.705 -2.558  1.000 43.804 ? 79  THR A O   1 ? 
ATOM   135  C CB  . THR A 1 53  ? -33.129 -37.590 -1.541  1.000 48.176 ? 79  THR A CB  1 ? 
ATOM   136  O OG1 . THR A 1 53  ? -32.150 -36.558 -1.442  1.000 42.563 ? 79  THR A OG1 1 ? 
ATOM   137  C CG2 . THR A 1 53  ? -32.559 -38.938 -1.181  1.000 40.834 ? 79  THR A CG2 1 ? 
ATOM   138  N N   . GLY A 1 54  ? -33.960 -35.615 -4.498  1.000 38.762 ? 80  GLY A N   1 ? 
ATOM   139  C CA  . GLY A 1 54  ? -34.695 -34.452 -5.006  1.000 38.624 ? 80  GLY A CA  1 ? 
ATOM   140  C C   . GLY A 1 54  ? -33.885 -33.207 -5.177  1.000 38.076 ? 80  GLY A C   1 ? 
ATOM   141  O O   . GLY A 1 54  ? -32.633 -33.224 -4.992  1.000 40.626 ? 80  GLY A O   1 ? 
ATOM   142  N N   . ILE A 1 55  ? -34.612 -32.144 -5.476  1.000 33.336 ? 81  ILE A N   1 ? 
ATOM   143  C CA  . ILE A 1 55  ? -34.056 -30.837 -5.880  1.000 34.524 ? 81  ILE A CA  1 ? 
ATOM   144  C C   . ILE A 1 55  ? -34.960 -29.796 -5.312  1.000 39.393 ? 81  ILE A C   1 ? 
ATOM   145  O O   . ILE A 1 55  ? -36.104 -29.699 -5.778  1.000 43.883 ? 81  ILE A O   1 ? 
ATOM   146  C CB  . ILE A 1 55  ? -33.931 -30.708 -7.413  1.000 34.844 ? 81  ILE A CB  1 ? 
ATOM   147  C CG1 . ILE A 1 55  ? -33.198 -31.910 -8.017  1.000 38.007 ? 81  ILE A CG1 1 ? 
ATOM   148  C CG2 . ILE A 1 55  ? -33.316 -29.370 -7.775  1.000 35.775 ? 81  ILE A CG2 1 ? 
ATOM   149  C CD1 . ILE A 1 55  ? -33.208 -31.978 -9.549  1.000 43.546 ? 81  ILE A CD1 1 ? 
ATOM   150  N N   . THR A 1 56  ? -34.426 -29.007 -4.405  1.000 35.657 ? 82  THR A N   1 ? 
ATOM   151  C CA  . THR A 1 56  ? -35.157 -27.906 -3.759  1.000 42.147 ? 82  THR A CA  1 ? 
ATOM   152  C C   . THR A 1 56  ? -34.710 -26.642 -4.451  1.000 43.963 ? 82  THR A C   1 ? 
ATOM   153  O O   . THR A 1 56  ? -33.649 -26.694 -5.085  1.000 43.688 ? 82  THR A O   1 ? 
ATOM   154  C CB  . THR A 1 56  ? -34.851 -27.900 -2.256  1.000 49.385 ? 82  THR A CB  1 ? 
ATOM   155  O OG1 . THR A 1 56  ? -35.348 -29.163 -1.827  1.000 45.688 ? 82  THR A OG1 1 ? 
ATOM   156  C CG2 . THR A 1 56  ? -35.516 -26.779 -1.492  1.000 56.599 ? 82  THR A CG2 1 ? 
ATOM   157  N N   . ASP A 1 57  ? -35.444 -25.546 -4.279  1.000 38.342 ? 83  ASP A N   1 ? 
ATOM   158  C CA  . ASP A 1 57  ? -35.204 -24.344 -5.084  1.000 40.314 ? 83  ASP A CA  1 ? 
ATOM   159  C C   . ASP A 1 57  ? -35.912 -23.166 -4.464  1.000 42.460 ? 83  ASP A C   1 ? 
ATOM   160  O O   . ASP A 1 57  ? -37.119 -23.288 -4.138  1.000 54.950 ? 83  ASP A O   1 ? 
ATOM   161  C CB  . ASP A 1 57  ? -35.649 -24.531 -6.545  1.000 44.898 ? 83  ASP A CB  1 ? 
ATOM   162  C CG  . ASP A 1 57  ? -35.457 -23.279 -7.401  1.000 47.390 ? 83  ASP A CG  1 ? 
ATOM   163  O OD1 . ASP A 1 57  ? -34.290 -22.849 -7.571  1.000 54.899 ? 83  ASP A OD1 1 ? 
ATOM   164  O OD2 . ASP A 1 57  ? -36.481 -22.708 -7.893  1.000 51.145 ? 83  ASP A OD2 1 ? 
ATOM   165  N N   . VAL A 1 58  ? -35.193 -22.062 -4.382  1.000 42.739 ? 84  VAL A N   1 ? 
ATOM   166  C CA  . VAL A 1 58  ? -35.758 -20.724 -4.106  1.000 47.236 ? 84  VAL A CA  1 ? 
ATOM   167  C C   . VAL A 1 58  ? -35.832 -20.058 -5.467  1.000 49.167 ? 84  VAL A C   1 ? 
ATOM   168  O O   . VAL A 1 58  ? -34.781 -19.883 -6.088  1.000 44.908 ? 84  VAL A O   1 ? 
ATOM   169  C CB  . VAL A 1 58  ? -34.930 -19.907 -3.096  1.000 50.550 ? 84  VAL A CB  1 ? 
ATOM   170  C CG1 . VAL A 1 58  ? -35.496 -18.502 -2.936  1.000 50.557 ? 84  VAL A CG1 1 ? 
ATOM   171  C CG2 . VAL A 1 58  ? -34.835 -20.617 -1.756  1.000 52.566 ? 84  VAL A CG2 1 ? 
ATOM   172  N N   . TYR A 1 59  ? -37.057 -19.808 -5.933  1.000 43.534 ? 85  TYR A N   1 ? 
ATOM   173  C CA  . TYR A 1 59  ? -37.378 -19.209 -7.250  1.000 45.569 ? 85  TYR A CA  1 ? 
ATOM   174  C C   . TYR A 1 59  ? -36.725 -17.833 -7.254  1.000 43.449 ? 85  TYR A C   1 ? 
ATOM   175  O O   . TYR A 1 59  ? -36.732 -17.175 -6.222  1.000 45.347 ? 85  TYR A O   1 ? 
ATOM   176  C CB  . TYR A 1 59  ? -38.911 -19.228 -7.437  1.000 45.680 ? 85  TYR A CB  1 ? 
ATOM   177  C CG  . TYR A 1 59  ? -39.376 -18.734 -8.780  1.000 45.425 ? 85  TYR A CG  1 ? 
ATOM   178  C CD1 . TYR A 1 59  ? -39.617 -17.379 -9.006  1.000 49.643 ? 85  TYR A CD1 1 ? 
ATOM   179  C CD2 . TYR A 1 59  ? -39.550 -19.619 -9.834  1.000 47.958 ? 85  TYR A CD2 1 ? 
ATOM   180  C CE1 . TYR A 1 59  ? -40.044 -16.921 -10.248 1.000 44.842 ? 85  TYR A CE1 1 ? 
ATOM   181  C CE2 . TYR A 1 59  ? -39.982 -19.180 -11.076 1.000 45.137 ? 85  TYR A CE2 1 ? 
ATOM   182  C CZ  . TYR A 1 59  ? -40.215 -17.833 -11.282 1.000 47.289 ? 85  TYR A CZ  1 ? 
ATOM   183  O OH  . TYR A 1 59  ? -40.633 -17.420 -12.509 1.000 58.369 ? 85  TYR A OH  1 ? 
ATOM   184  N N   . LYS A 1 60  ? -36.094 -17.394 -8.350  1.000 42.922 ? 86  LYS A N   1 ? 
ATOM   185  C CA  . LYS A 1 60  ? -35.994 -18.086 -9.626  1.000 47.218 ? 86  LYS A CA  1 ? 
ATOM   186  C C   . LYS A 1 60  ? -34.541 -18.528 -9.903  1.000 40.062 ? 86  LYS A C   1 ? 
ATOM   187  O O   . LYS A 1 60  ? -33.689 -17.668 -9.890  1.000 42.187 ? 86  LYS A O   1 ? 
ATOM   188  C CB  . LYS A 1 60  ? -36.408 -17.072 -10.692 1.000 47.992 ? 86  LYS A CB  1 ? 
ATOM   189  C CG  . LYS A 1 60  ? -36.698 -17.608 -12.089 1.000 52.321 ? 86  LYS A CG  1 ? 
ATOM   190  C CD  . LYS A 1 60  ? -36.558 -16.500 -13.124 1.000 53.779 ? 86  LYS A CD  1 ? 
ATOM   191  C CE  . LYS A 1 60  ? -37.300 -16.746 -14.417 1.000 66.848 ? 86  LYS A CE  1 ? 
ATOM   192  N NZ  . LYS A 1 60  ? -37.331 -18.187 -14.777 1.000 71.454 ? 86  LYS A NZ  1 ? 
ATOM   193  N N   . SER A 1 61  ? -34.315 -19.789 -10.259 1.000 39.134 ? 87  SER A N   1 ? 
ATOM   194  C CA  . SER A 1 61  ? -33.010 -20.303 -10.757 1.000 41.738 ? 87  SER A CA  1 ? 
ATOM   195  C C   . SER A 1 61  ? -33.034 -20.372 -12.287 1.000 42.965 ? 87  SER A C   1 ? 
ATOM   196  O O   . SER A 1 61  ? -34.138 -20.364 -12.873 1.000 38.305 ? 87  SER A O   1 ? 
ATOM   197  C CB  . SER A 1 61  ? -32.733 -21.620 -10.149 1.000 41.021 ? 87  SER A CB  1 ? 
ATOM   198  O OG  . SER A 1 61  ? -32.544 -21.457 -8.769  1.000 41.482 ? 87  SER A OG  1 ? 
ATOM   199  N N   . ALA A 1 62  ? -31.861 -20.461 -12.914 1.000 37.334 ? 88  ALA A N   1 ? 
ATOM   200  C CA  . ALA A 1 62  ? -31.694 -20.574 -14.386 1.000 36.715 ? 88  ALA A CA  1 ? 
ATOM   201  C C   . ALA A 1 62  ? -30.750 -21.733 -14.672 1.000 38.108 ? 88  ALA A C   1 ? 
ATOM   202  O O   . ALA A 1 62  ? -29.480 -21.596 -14.539 1.000 36.229 ? 88  ALA A O   1 ? 
ATOM   203  C CB  . ALA A 1 62  ? -31.211 -19.267 -14.956 1.000 38.057 ? 88  ALA A CB  1 ? 
ATOM   204  N N   . ILE A 1 63  ? -31.347 -22.872 -14.964 1.000 31.946 ? 89  ILE A N   1 ? 
ATOM   205  C CA  . ILE A 1 63  ? -30.631 -24.130 -15.244 1.000 33.052 ? 89  ILE A CA  1 ? 
ATOM   206  C C   . ILE A 1 63  ? -30.593 -24.400 -16.752 1.000 37.001 ? 89  ILE A C   1 ? 
ATOM   207  O O   . ILE A 1 63  ? -31.631 -24.436 -17.389 1.000 32.571 ? 89  ILE A O   1 ? 
ATOM   208  C CB  . ILE A 1 63  ? -31.259 -25.264 -14.447 1.000 30.183 ? 89  ILE A CB  1 ? 
ATOM   209  C CG1 . ILE A 1 63  ? -31.236 -24.940 -12.938 1.000 33.552 ? 89  ILE A CG1 1 ? 
ATOM   210  C CG2 . ILE A 1 63  ? -30.545 -26.569 -14.759 1.000 30.068 ? 89  ILE A CG2 1 ? 
ATOM   211  C CD1 . ILE A 1 63  ? -32.514 -25.305 -12.245 1.000 35.705 ? 89  ILE A CD1 1 ? 
ATOM   212  N N   . THR A 1 64  ? -29.406 -24.625 -17.302 1.000 29.750 ? 90  THR A N   1 ? 
ATOM   213  C CA  . THR A 1 64  ? -29.249 -25.051 -18.714 1.000 29.204 ? 90  THR A CA  1 ? 
ATOM   214  C C   . THR A 1 64  ? -28.736 -26.495 -18.722 1.000 34.312 ? 90  THR A C   1 ? 
ATOM   215  O O   . THR A 1 64  ? -27.519 -26.721 -18.330 1.000 33.647 ? 90  THR A O   1 ? 
ATOM   216  C CB  . THR A 1 64  ? -28.337 -24.104 -19.484 1.000 32.706 ? 90  THR A CB  1 ? 
ATOM   217  O OG1 . THR A 1 64  ? -28.862 -22.767 -19.368 1.000 33.212 ? 90  THR A OG1 1 ? 
ATOM   218  C CG2 . THR A 1 64  ? -28.212 -24.548 -20.930 1.000 36.551 ? 90  THR A CG2 1 ? 
ATOM   219  N N   . GLY A 1 65  ? -29.561 -27.406 -19.234 1.000 29.822 ? 91  GLY A N   1 ? 
ATOM   220  C CA  . GLY A 1 65  ? -29.271 -28.861 -19.316 1.000 32.836 ? 91  GLY A CA  1 ? 
ATOM   221  C C   . GLY A 1 65  ? -30.410 -29.644 -18.712 1.000 32.641 ? 91  GLY A C   1 ? 
ATOM   222  O O   . GLY A 1 65  ? -31.240 -29.019 -18.053 1.000 34.610 ? 91  GLY A O   1 ? 
ATOM   223  N N   . ASP A 1 66  ? -30.413 -30.974 -18.847 1.000 32.597 ? 92  ASP A N   1 ? 
ATOM   224  C CA  . ASP A 1 66  ? -31.483 -31.815 -18.274 1.000 32.701 ? 92  ASP A CA  1 ? 
ATOM   225  C C   . ASP A 1 66  ? -31.306 -31.899 -16.742 1.000 33.370 ? 92  ASP A C   1 ? 
ATOM   226  O O   . ASP A 1 66  ? -30.156 -31.833 -16.177 1.000 27.846 ? 92  ASP A O   1 ? 
ATOM   227  C CB  . ASP A 1 66  ? -31.539 -33.197 -18.947 1.000 32.561 ? 92  ASP A CB  1 ? 
ATOM   228  C CG  . ASP A 1 66  ? -31.795 -33.171 -20.457 1.000 34.802 ? 92  ASP A CG  1 ? 
ATOM   229  O OD1 . ASP A 1 66  ? -32.245 -32.116 -21.016 1.000 29.717 ? 92  ASP A OD1 1 ? 
ATOM   230  O OD2 . ASP A 1 66  ? -31.494 -34.193 -21.080 1.000 33.474 ? 92  ASP A OD2 1 ? 
ATOM   231  N N   . VAL A 1 67  ? -32.419 -32.093 -16.057 1.000 31.084 ? 93  VAL A N   1 ? 
ATOM   232  C CA  . VAL A 1 67  ? -32.441 -32.411 -14.599 1.000 31.493 ? 93  VAL A CA  1 ? 
ATOM   233  C C   . VAL A 1 67  ? -33.245 -33.697 -14.345 1.000 36.694 ? 93  VAL A C   1 ? 
ATOM   234  O O   . VAL A 1 67  ? -34.217 -34.057 -15.106 1.000 36.805 ? 93  VAL A O   1 ? 
ATOM   235  C CB  . VAL A 1 67  ? -32.910 -31.234 -13.738 1.000 35.113 ? 93  VAL A CB  1 ? 
ATOM   236  C CG1 . VAL A 1 67  ? -32.355 -29.910 -14.217 1.000 37.207 ? 93  VAL A CG1 1 ? 
ATOM   237  C CG2 . VAL A 1 67  ? -34.411 -31.152 -13.606 1.000 44.011 ? 93  VAL A CG2 1 ? 
ATOM   238  N N   . GLY A 1 68  ? -32.875 -34.380 -13.273 1.000 33.728 ? 94  GLY A N   1 ? 
ATOM   239  C CA  . GLY A 1 68  ? -33.478 -35.666 -12.926 1.000 35.441 ? 94  GLY A CA  1 ? 
ATOM   240  C C   . GLY A 1 68  ? -33.309 -35.958 -11.454 1.000 42.552 ? 94  GLY A C   1 ? 
ATOM   241  O O   . GLY A 1 68  ? -32.409 -35.401 -10.819 1.000 36.344 ? 94  GLY A O   1 ? 
ATOM   242  N N   . ALA A 1 69  ? -34.169 -36.811 -10.928 1.000 45.469 ? 95  ALA A N   1 ? 
ATOM   243  C CA  . ALA A 1 69  ? -34.055 -37.364 -9.569  1.000 41.572 ? 95  ALA A CA  1 ? 
ATOM   244  C C   . ALA A 1 69  ? -34.634 -38.771 -9.602  1.000 42.404 ? 95  ALA A C   1 ? 
ATOM   245  O O   . ALA A 1 69  ? -35.596 -39.030 -10.357 1.000 43.443 ? 95  ALA A O   1 ? 
ATOM   246  C CB  . ALA A 1 69  ? -34.723 -36.456 -8.569  1.000 39.604 ? 95  ALA A CB  1 ? 
ATOM   247  N N   . CYS A 1 70  ? -34.044 -39.658 -8.833  1.000 46.124 ? 96  CYS A N   1 ? 
ATOM   248  C CA  . CYS A 1 70  ? -34.387 -41.098 -8.870  1.000 50.199 ? 96  CYS A CA  1 ? 
ATOM   249  C C   . CYS A 1 70  ? -33.564 -41.821 -7.804  1.000 45.843 ? 96  CYS A C   1 ? 
ATOM   250  O O   . CYS A 1 70  ? -32.336 -41.649 -7.770  1.000 42.925 ? 96  CYS A O   1 ? 
ATOM   251  C CB  . CYS A 1 70  ? -34.138 -41.585 -10.297 1.000 52.336 ? 96  CYS A CB  1 ? 
ATOM   252  S SG  . CYS A 1 70  ? -33.959 -43.375 -10.417 1.000 64.873 ? 96  CYS A SG  1 ? 
ATOM   253  N N   . PRO A 1 71  ? -34.148 -42.740 -6.988  1.000 45.300 ? 97  PRO A N   1 ? 
ATOM   254  C CA  . PRO A 1 71  ? -35.495 -43.281 -7.200  1.000 39.050 ? 97  PRO A CA  1 ? 
ATOM   255  C C   . PRO A 1 71  ? -36.629 -42.513 -6.518  1.000 40.160 ? 97  PRO A C   1 ? 
ATOM   256  O O   . PRO A 1 71  ? -37.756 -42.932 -6.629  1.000 43.156 ? 97  PRO A O   1 ? 
ATOM   257  C CB  . PRO A 1 71  ? -35.377 -44.715 -6.641  1.000 43.472 ? 97  PRO A CB  1 ? 
ATOM   258  C CG  . PRO A 1 71  ? -34.366 -44.599 -5.495  1.000 44.676 ? 97  PRO A CG  1 ? 
ATOM   259  C CD  . PRO A 1 71  ? -33.437 -43.474 -5.920  1.000 47.282 ? 97  PRO A CD  1 ? 
ATOM   260  N N   . ILE A 1 72  ? -36.366 -41.366 -5.910  1.000 38.065 ? 98  ILE A N   1 ? 
ATOM   261  C CA  . ILE A 1 72  ? -37.443 -40.559 -5.282  1.000 37.305 ? 98  ILE A CA  1 ? 
ATOM   262  C C   . ILE A 1 72  ? -38.529 -40.229 -6.331  1.000 40.513 ? 98  ILE A C   1 ? 
ATOM   263  O O   . ILE A 1 72  ? -38.208 -40.148 -7.529  1.000 37.258 ? 98  ILE A O   1 ? 
ATOM   264  C CB  . ILE A 1 72  ? -36.824 -39.299 -4.651  1.000 35.100 ? 98  ILE A CB  1 ? 
ATOM   265  C CG1 . ILE A 1 72  ? -37.739 -38.690 -3.586  1.000 39.717 ? 98  ILE A CG1 1 ? 
ATOM   266  C CG2 . ILE A 1 72  ? -36.433 -38.312 -5.711  1.000 35.661 ? 98  ILE A CG2 1 ? 
ATOM   267  C CD1 . ILE A 1 72  ? -37.810 -39.517 -2.327  1.000 42.861 ? 98  ILE A CD1 1 ? 
ATOM   268  N N   . THR A 1 73  ? -39.766 -39.955 -5.902  1.000 43.390 ? 99  THR A N   1 ? 
ATOM   269  C CA  . THR A 1 73  ? -40.867 -39.443 -6.766  1.000 40.698 ? 99  THR A CA  1 ? 
ATOM   270  C C   . THR A 1 73  ? -40.507 -38.039 -7.298  1.000 40.839 ? 99  THR A C   1 ? 
ATOM   271  O O   . THR A 1 73  ? -39.869 -37.286 -6.585  1.000 38.540 ? 99  THR A O   1 ? 
ATOM   272  C CB  . THR A 1 73  ? -42.222 -39.401 -6.028  1.000 43.463 ? 99  THR A CB  1 ? 
ATOM   273  O OG1 . THR A 1 73  ? -43.113 -38.576 -6.782  1.000 39.296 ? 99  THR A OG1 1 ? 
ATOM   274  C CG2 . THR A 1 73  ? -42.137 -38.777 -4.655  1.000 44.007 ? 99  THR A CG2 1 ? 
ATOM   275  N N   . GLY A 1 74  ? -40.905 -37.720 -8.533  1.000 32.926 ? 100 GLY A N   1 ? 
ATOM   276  C CA  . GLY A 1 74  ? -40.699 -36.414 -9.169  1.000 32.253 ? 100 GLY A CA  1 ? 
ATOM   277  C C   . GLY A 1 74  ? -41.315 -35.261 -8.450  1.000 34.723 ? 100 GLY A C   1 ? 
ATOM   278  O O   . GLY A 1 74  ? -40.945 -34.115 -8.755  1.000 36.625 ? 100 GLY A O   1 ? 
ATOM   279  N N   . ALA A 1 75  ? -42.270 -35.513 -7.544  1.000 42.325 ? 101 ALA A N   1 ? 
ATOM   280  C CA  . ALA A 1 75  ? -42.762 -34.471 -6.615  1.000 40.409 ? 101 ALA A CA  1 ? 
ATOM   281  C C   . ALA A 1 75  ? -41.580 -33.869 -5.838  1.000 34.306 ? 101 ALA A C   1 ? 
ATOM   282  O O   . ALA A 1 75  ? -41.700 -32.692 -5.449  1.000 39.116 ? 101 ALA A O   1 ? 
ATOM   283  C CB  . ALA A 1 75  ? -43.805 -35.026 -5.662  1.000 42.965 ? 101 ALA A CB  1 ? 
ATOM   284  N N   . ALA A 1 76  ? -40.473 -34.600 -5.645  1.000 40.785 ? 102 ALA A N   1 ? 
ATOM   285  C CA  . ALA A 1 76  ? -39.297 -34.064 -4.891  1.000 41.887 ? 102 ALA A CA  1 ? 
ATOM   286  C C   . ALA A 1 76  ? -38.509 -33.038 -5.726  1.000 44.397 ? 102 ALA A C   1 ? 
ATOM   287  O O   . ALA A 1 76  ? -37.615 -32.377 -5.151  1.000 37.593 ? 102 ALA A O   1 ? 
ATOM   288  C CB  . ALA A 1 76  ? -38.424 -35.175 -4.355  1.000 41.765 ? 102 ALA A CB  1 ? 
ATOM   289  N N   . ILE A 1 77  ? -38.845 -32.844 -7.013  1.000 38.731 ? 103 ILE A N   1 ? 
ATOM   290  C CA  . ILE A 1 77  ? -38.256 -31.780 -7.871  1.000 36.666 ? 103 ILE A CA  1 ? 
ATOM   291  C C   . ILE A 1 77  ? -39.119 -30.533 -7.775  1.000 39.699 ? 103 ILE A C   1 ? 
ATOM   292  O O   . ILE A 1 77  ? -40.193 -30.524 -8.379  1.000 49.730 ? 103 ILE A O   1 ? 
ATOM   293  C CB  . ILE A 1 77  ? -38.053 -32.254 -9.328  1.000 40.726 ? 103 ILE A CB  1 ? 
ATOM   294  C CG1 . ILE A 1 77  ? -37.220 -33.538 -9.373  1.000 40.660 ? 103 ILE A CG1 1 ? 
ATOM   295  C CG2 . ILE A 1 77  ? -37.453 -31.129 -10.171 1.000 41.174 ? 103 ILE A CG2 1 ? 
ATOM   296  C CD1 . ILE A 1 77  ? -37.307 -34.319 -10.634 1.000 41.175 ? 103 ILE A CD1 1 ? 
ATOM   297  N N   . LEU A 1 78  ? -38.641 -29.509 -7.070  1.000 34.188 ? 104 LEU A N   1 ? 
ATOM   298  C CA  . LEU A 1 78  ? -39.392 -28.262 -6.734  1.000 40.377 ? 104 LEU A CA  1 ? 
ATOM   299  C C   . LEU A 1 78  ? -39.058 -27.149 -7.716  1.000 38.526 ? 104 LEU A C   1 ? 
ATOM   300  O O   . LEU A 1 78  ? -39.022 -25.967 -7.335  1.000 56.850 ? 104 LEU A O   1 ? 
ATOM   301  C CB  . LEU A 1 78  ? -39.113 -27.867 -5.276  1.000 39.216 ? 104 LEU A CB  1 ? 
ATOM   302  C CG  . LEU A 1 78  ? -39.253 -29.007 -4.251  1.000 39.066 ? 104 LEU A CG  1 ? 
ATOM   303  C CD1 . LEU A 1 78  ? -39.203 -28.455 -2.823  1.000 43.701 ? 104 LEU A CD1 1 ? 
ATOM   304  C CD2 . LEU A 1 78  ? -40.542 -29.788 -4.473  1.000 42.314 ? 104 LEU A CD2 1 ? 
ATOM   305  N N   . LEU A 1 79  ? -38.718 -27.537 -8.934  1.000 44.923 ? 105 LEU A N   1 ? 
ATOM   306  C CA  . LEU A 1 79  ? -38.356 -26.607 -10.014 1.000 40.827 ? 105 LEU A CA  1 ? 
ATOM   307  C C   . LEU A 1 79  ? -39.610 -26.382 -10.856 1.000 45.579 ? 105 LEU A C   1 ? 
ATOM   308  O O   . LEU A 1 79  ? -40.289 -27.343 -11.089 1.000 43.891 ? 105 LEU A O   1 ? 
ATOM   309  C CB  . LEU A 1 79  ? -37.234 -27.233 -10.841 1.000 39.006 ? 105 LEU A CB  1 ? 
ATOM   310  C CG  . LEU A 1 79  ? -35.855 -27.103 -10.213 1.000 37.503 ? 105 LEU A CG  1 ? 
ATOM   311  C CD1 . LEU A 1 79  ? -34.844 -27.914 -10.984 1.000 37.091 ? 105 LEU A CD1 1 ? 
ATOM   312  C CD2 . LEU A 1 79  ? -35.411 -25.651 -10.105 1.000 36.912 ? 105 LEU A CD2 1 ? 
ATOM   313  N N   . LYS A 1 80  ? -39.870 -25.137 -11.245 1.000 44.792 ? 106 LYS A N   1 ? 
ATOM   314  C CA  . LYS A 1 80  ? -40.823 -24.738 -12.304 1.000 49.862 ? 106 LYS A CA  1 ? 
ATOM   315  C C   . LYS A 1 80  ? -40.202 -24.953 -13.688 1.000 53.154 ? 106 LYS A C   1 ? 
ATOM   316  O O   . LYS A 1 80  ? -38.961 -24.938 -13.834 1.000 42.951 ? 106 LYS A O   1 ? 
ATOM   317  C CB  . LYS A 1 80  ? -41.153 -23.251 -12.191 1.000 54.126 ? 106 LYS A CB  1 ? 
ATOM   318  C CG  . LYS A 1 80  ? -41.557 -22.781 -10.803 1.000 62.945 ? 106 LYS A CG  1 ? 
ATOM   319  C CD  . LYS A 1 80  ? -42.737 -23.531 -10.248 1.000 70.840 ? 106 LYS A CD  1 ? 
ATOM   320  C CE  . LYS A 1 80  ? -43.290 -22.883 -8.996  1.000 74.888 ? 106 LYS A CE  1 ? 
ATOM   321  N NZ  . LYS A 1 80  ? -43.778 -23.924 -8.063  1.000 75.823 ? 106 LYS A NZ  1 ? 
ATOM   322  N N   . CYS A 1 81  ? -41.070 -25.050 -14.688 1.000 49.469 ? 107 CYS A N   1 ? 
ATOM   323  C CA  . CYS A 1 81  ? -40.738 -25.260 -16.118 1.000 49.916 ? 107 CYS A CA  1 ? 
ATOM   324  C C   . CYS A 1 81  ? -39.916 -24.103 -16.673 1.000 43.502 ? 107 CYS A C   1 ? 
ATOM   325  O O   . CYS A 1 81  ? -38.966 -24.353 -17.395 1.000 46.872 ? 107 CYS A O   1 ? 
ATOM   326  C CB  . CYS A 1 81  ? -42.041 -25.477 -16.875 1.000 57.063 ? 107 CYS A CB  1 ? 
ATOM   327  S SG  . CYS A 1 81  ? -42.769 -27.038 -16.319 1.000 68.247 ? 107 CYS A SG  1 ? 
ATOM   328  N N   . ASP A 1 82  ? -40.248 -22.882 -16.289 1.000 48.051 ? 108 ASP A N   1 ? 
ATOM   329  C CA  . ASP A 1 82  ? -39.547 -21.657 -16.715 1.000 43.154 ? 108 ASP A CA  1 ? 
ATOM   330  C C   . ASP A 1 82  ? -38.121 -21.636 -16.118 1.000 46.496 ? 108 ASP A C   1 ? 
ATOM   331  O O   . ASP A 1 82  ? -37.360 -20.746 -16.509 1.000 42.554 ? 108 ASP A O   1 ? 
ATOM   332  C CB  . ASP A 1 82  ? -40.417 -20.430 -16.420 1.000 51.323 ? 108 ASP A CB  1 ? 
ATOM   333  C CG  . ASP A 1 82  ? -40.595 -20.053 -14.952 1.000 52.570 ? 108 ASP A CG  1 ? 
ATOM   334  O OD1 . ASP A 1 82  ? -40.687 -20.958 -14.113 1.000 52.602 ? 108 ASP A OD1 1 ? 
ATOM   335  O OD2 . ASP A 1 82  ? -40.613 -18.846 -14.665 1.000 57.197 ? 108 ASP A OD2 1 ? 
ATOM   336  N N   . GLU A 1 83  ? -37.720 -22.576 -15.248 1.000 43.771 ? 109 GLU A N   1 ? 
ATOM   337  C CA  . GLU A 1 83  ? -36.365 -22.514 -14.611 1.000 39.390 ? 109 GLU A CA  1 ? 
ATOM   338  C C   . GLU A 1 83  ? -35.360 -23.407 -15.341 1.000 38.919 ? 109 GLU A C   1 ? 
ATOM   339  O O   . GLU A 1 83  ? -34.133 -23.269 -15.060 1.000 37.984 ? 109 GLU A O   1 ? 
ATOM   340  C CB  . GLU A 1 83  ? -36.475 -22.875 -13.129 1.000 39.066 ? 109 GLU A CB  1 ? 
ATOM   341  C CG  . GLU A 1 83  ? -37.123 -21.764 -12.319 1.000 38.598 ? 109 GLU A CG  1 ? 
ATOM   342  C CD  . GLU A 1 83  ? -37.171 -22.138 -10.857 1.000 40.092 ? 109 GLU A CD  1 ? 
ATOM   343  O OE1 . GLU A 1 83  ? -36.460 -21.491 -10.091 1.000 42.408 ? 109 GLU A OE1 1 ? 
ATOM   344  O OE2 . GLU A 1 83  ? -37.913 -23.075 -10.512 1.000 37.938 ? 109 GLU A OE2 1 ? 
ATOM   345  N N   . VAL A 1 84  ? -35.840 -24.299 -16.213 1.000 39.618 ? 110 VAL A N   1 ? 
ATOM   346  C CA  . VAL A 1 84  ? -35.033 -25.378 -16.829 1.000 40.744 ? 110 VAL A CA  1 ? 
ATOM   347  C C   . VAL A 1 84  ? -35.088 -25.224 -18.351 1.000 40.414 ? 110 VAL A C   1 ? 
ATOM   348  O O   . VAL A 1 84  ? -36.177 -25.249 -18.906 1.000 34.803 ? 110 VAL A O   1 ? 
ATOM   349  C CB  . VAL A 1 84  ? -35.485 -26.777 -16.383 1.000 36.062 ? 110 VAL A CB  1 ? 
ATOM   350  C CG1 . VAL A 1 84  ? -34.606 -27.848 -17.006 1.000 38.884 ? 110 VAL A CG1 1 ? 
ATOM   351  C CG2 . VAL A 1 84  ? -35.473 -26.926 -14.867 1.000 39.922 ? 110 VAL A CG2 1 ? 
ATOM   352  N N   . THR A 1 85  ? -33.930 -24.998 -18.967 1.000 37.497 ? 111 THR A N   1 ? 
ATOM   353  C CA  . THR A 1 85  ? -33.723 -25.102 -20.428 1.000 34.230 ? 111 THR A CA  1 ? 
ATOM   354  C C   . THR A 1 85  ? -33.173 -26.488 -20.713 1.000 35.267 ? 111 THR A C   1 ? 
ATOM   355  O O   . THR A 1 85  ? -31.961 -26.680 -20.616 1.000 37.218 ? 111 THR A O   1 ? 
ATOM   356  C CB  . THR A 1 85  ? -32.797 -24.004 -20.938 1.000 37.587 ? 111 THR A CB  1 ? 
ATOM   357  O OG1 . THR A 1 85  ? -33.455 -22.802 -20.551 1.000 32.927 ? 111 THR A OG1 1 ? 
ATOM   358  C CG2 . THR A 1 85  ? -32.569 -24.060 -22.436 1.000 35.639 ? 111 THR A CG2 1 ? 
ATOM   359  N N   . GLY A 1 86  ? -34.062 -27.407 -21.060 1.000 31.129 ? 112 GLY A N   1 ? 
ATOM   360  C CA  . GLY A 1 86  ? -33.819 -28.855 -21.072 1.000 33.507 ? 112 GLY A CA  1 ? 
ATOM   361  C C   . GLY A 1 86  ? -35.070 -29.588 -20.648 1.000 38.715 ? 112 GLY A C   1 ? 
ATOM   362  O O   . GLY A 1 86  ? -36.147 -28.942 -20.579 1.000 36.093 ? 112 GLY A O   1 ? 
ATOM   363  N N   . THR A 1 87  ? -34.901 -30.870 -20.312 1.000 35.859 ? 113 THR A N   1 ? 
ATOM   364  C CA  . THR A 1 87  ? -35.985 -31.791 -19.921 1.000 36.667 ? 113 THR A CA  1 ? 
ATOM   365  C C   . THR A 1 87  ? -35.850 -32.075 -18.414 1.000 37.875 ? 113 THR A C   1 ? 
ATOM   366  O O   . THR A 1 87  ? -34.708 -32.279 -17.881 1.000 33.403 ? 113 THR A O   1 ? 
ATOM   367  C CB  . THR A 1 87  ? -35.896 -33.055 -20.787 1.000 39.814 ? 113 THR A CB  1 ? 
ATOM   368  O OG1 . THR A 1 87  ? -36.020 -32.686 -22.178 1.000 37.788 ? 113 THR A OG1 1 ? 
ATOM   369  C CG2 . THR A 1 87  ? -36.897 -34.101 -20.349 1.000 37.772 ? 113 THR A CG2 1 ? 
ATOM   370  N N   . ILE A 1 88  ? -36.974 -32.063 -17.730 1.000 32.938 ? 114 ILE A N   1 ? 
ATOM   371  C CA  . ILE A 1 88  ? -37.100 -32.512 -16.319 1.000 32.320 ? 114 ILE A CA  1 ? 
ATOM   372  C C   . ILE A 1 88  ? -37.619 -33.935 -16.384 1.000 34.749 ? 114 ILE A C   1 ? 
ATOM   373  O O   . ILE A 1 88  ? -38.801 -34.117 -16.843 1.000 36.645 ? 114 ILE A O   1 ? 
ATOM   374  C CB  . ILE A 1 88  ? -38.015 -31.604 -15.509 1.000 38.827 ? 114 ILE A CB  1 ? 
ATOM   375  C CG1 . ILE A 1 88  ? -37.507 -30.171 -15.473 1.000 37.124 ? 114 ILE A CG1 1 ? 
ATOM   376  C CG2 . ILE A 1 88  ? -38.249 -32.160 -14.106 1.000 42.747 ? 114 ILE A CG2 1 ? 
ATOM   377  C CD1 . ILE A 1 88  ? -38.421 -29.250 -14.691 1.000 45.299 ? 114 ILE A CD1 1 ? 
ATOM   378  N N   . PHE A 1 89  ? -36.803 -34.868 -15.903 1.000 28.459 ? 115 PHE A N   1 ? 
ATOM   379  C CA  . PHE A 1 89  ? -37.074 -36.329 -15.851 1.000 32.119 ? 115 PHE A CA  1 ? 
ATOM   380  C C   . PHE A 1 89  ? -37.601 -36.734 -14.462 1.000 43.452 ? 115 PHE A C   1 ? 
ATOM   381  O O   . PHE A 1 89  ? -36.925 -36.353 -13.465 1.000 40.582 ? 115 PHE A O   1 ? 
ATOM   382  C CB  . PHE A 1 89  ? -35.806 -37.093 -16.183 1.000 36.971 ? 115 PHE A CB  1 ? 
ATOM   383  C CG  . PHE A 1 89  ? -35.514 -37.160 -17.652 1.000 37.121 ? 115 PHE A CG  1 ? 
ATOM   384  C CD1 . PHE A 1 89  ? -36.252 -38.001 -18.469 1.000 50.074 ? 115 PHE A CD1 1 ? 
ATOM   385  C CD2 . PHE A 1 89  ? -34.479 -36.426 -18.208 1.000 38.717 ? 115 PHE A CD2 1 ? 
ATOM   386  C CE1 . PHE A 1 89  ? -35.997 -38.066 -19.833 1.000 52.017 ? 115 PHE A CE1 1 ? 
ATOM   387  C CE2 . PHE A 1 89  ? -34.194 -36.528 -19.562 1.000 41.332 ? 115 PHE A CE2 1 ? 
ATOM   388  C CZ  . PHE A 1 89  ? -34.958 -37.343 -20.370 1.000 44.862 ? 115 PHE A CZ  1 ? 
ATOM   389  N N   . SER A 1 90  ? -38.736 -37.470 -14.409 1.000 39.963 ? 116 SER A N   1 ? 
ATOM   390  C CA  . SER A 1 90  ? -39.349 -38.077 -13.200 1.000 34.303 ? 116 SER A CA  1 ? 
ATOM   391  C C   . SER A 1 90  ? -39.337 -39.587 -13.385 1.000 35.893 ? 116 SER A C   1 ? 
ATOM   392  O O   . SER A 1 90  ? -39.471 -40.008 -14.545 1.000 35.371 ? 116 SER A O   1 ? 
ATOM   393  C CB  . SER A 1 90  ? -40.768 -37.553 -12.973 1.000 41.592 ? 116 SER A CB  1 ? 
ATOM   394  O OG  . SER A 1 90  ? -41.361 -38.220 -11.857 1.000 39.846 ? 116 SER A OG  1 ? 
ATOM   395  N N   . VAL A 1 91  ? -39.197 -40.363 -12.297 1.000 35.294 ? 117 VAL A N   1 ? 
ATOM   396  C CA  . VAL A 1 91  ? -39.429 -41.842 -12.316 1.000 37.979 ? 117 VAL A CA  1 ? 
ATOM   397  C C   . VAL A 1 91  ? -40.935 -42.133 -12.372 1.000 37.096 ? 117 VAL A C   1 ? 
ATOM   398  O O   . VAL A 1 91  ? -41.250 -43.296 -12.528 1.000 42.776 ? 117 VAL A O   1 ? 
ATOM   399  C CB  . VAL A 1 91  ? -38.869 -42.620 -11.111 1.000 38.267 ? 117 VAL A CB  1 ? 
ATOM   400  C CG1 . VAL A 1 91  ? -37.362 -42.707 -11.136 1.000 48.057 ? 117 VAL A CG1 1 ? 
ATOM   401  C CG2 . VAL A 1 91  ? -39.416 -42.108 -9.781  1.000 42.246 ? 117 VAL A CG2 1 ? 
ATOM   402  N N   . ASP A 1 92  ? -41.814 -41.144 -12.238 1.000 38.138 ? 118 ASP A N   1 ? 
ATOM   403  C CA  . ASP A 1 92  ? -43.266 -41.455 -12.088 1.000 43.199 ? 118 ASP A CA  1 ? 
ATOM   404  C C   . ASP A 1 92  ? -44.133 -40.311 -12.609 1.000 45.307 ? 118 ASP A C   1 ? 
ATOM   405  O O   . ASP A 1 92  ? -43.624 -39.412 -13.296 1.000 41.584 ? 118 ASP A O   1 ? 
ATOM   406  C CB  . ASP A 1 92  ? -43.544 -41.778 -10.616 1.000 42.583 ? 118 ASP A CB  1 ? 
ATOM   407  C CG  . ASP A 1 92  ? -43.349 -40.610 -9.665  1.000 38.717 ? 118 ASP A CG  1 ? 
ATOM   408  O OD1 . ASP A 1 92  ? -43.228 -39.445 -10.127 1.000 42.332 ? 118 ASP A OD1 1 ? 
ATOM   409  O OD2 . ASP A 1 92  ? -43.366 -40.856 -8.440  1.000 46.122 ? 118 ASP A OD2 1 ? 
ATOM   410  N N   . ALA A 1 93  ? -45.427 -40.332 -12.284 1.000 45.395 ? 119 ALA A N   1 ? 
ATOM   411  C CA  . ALA A 1 93  ? -46.420 -39.417 -12.856 1.000 42.999 ? 119 ALA A CA  1 ? 
ATOM   412  C C   . ALA A 1 93  ? -46.356 -38.068 -12.137 1.000 46.276 ? 119 ALA A C   1 ? 
ATOM   413  O O   . ALA A 1 93  ? -46.968 -37.111 -12.615 1.000 48.942 ? 119 ALA A O   1 ? 
ATOM   414  C CB  . ALA A 1 93  ? -47.798 -40.044 -12.766 1.000 46.669 ? 119 ALA A CB  1 ? 
ATOM   415  N N   . ALA A 1 94  ? -45.660 -37.951 -11.001 1.000 48.054 ? 120 ALA A N   1 ? 
ATOM   416  C CA  . ALA A 1 94  ? -45.576 -36.664 -10.258 1.000 45.625 ? 120 ALA A CA  1 ? 
ATOM   417  C C   . ALA A 1 94  ? -44.409 -35.796 -10.753 1.000 44.810 ? 120 ALA A C   1 ? 
ATOM   418  O O   . ALA A 1 94  ? -43.459 -36.318 -11.378 1.000 55.187 ? 120 ALA A O   1 ? 
ATOM   419  C CB  . ALA A 1 94  ? -45.475 -36.933 -8.766  1.000 48.711 ? 120 ALA A CB  1 ? 
ATOM   420  N N   . GLY A 1 95  ? -44.509 -34.495 -10.497 1.000 47.806 ? 121 GLY A N   1 ? 
ATOM   421  C CA  . GLY A 1 95  ? -43.429 -33.523 -10.721 1.000 54.318 ? 121 GLY A CA  1 ? 
ATOM   422  C C   . GLY A 1 95  ? -43.946 -32.274 -11.413 1.000 49.867 ? 121 GLY A C   1 ? 
ATOM   423  O O   . GLY A 1 95  ? -45.151 -32.096 -11.568 1.000 51.092 ? 121 GLY A O   1 ? 
ATOM   424  N N   . PRO A 1 96  ? -43.039 -31.377 -11.838 1.000 52.391 ? 122 PRO A N   1 ? 
ATOM   425  C CA  . PRO A 1 96  ? -43.446 -30.156 -12.529 1.000 50.780 ? 122 PRO A CA  1 ? 
ATOM   426  C C   . PRO A 1 96  ? -44.260 -30.556 -13.782 1.000 49.543 ? 122 PRO A C   1 ? 
ATOM   427  O O   . PRO A 1 96  ? -44.135 -31.696 -14.255 1.000 49.630 ? 122 PRO A O   1 ? 
ATOM   428  C CB  . PRO A 1 96  ? -42.101 -29.470 -12.858 1.000 53.806 ? 122 PRO A CB  1 ? 
ATOM   429  C CG  . PRO A 1 96  ? -41.098 -30.098 -11.906 1.000 52.640 ? 122 PRO A CG  1 ? 
ATOM   430  C CD  . PRO A 1 96  ? -41.570 -31.519 -11.705 1.000 52.063 ? 122 PRO A CD  1 ? 
ATOM   431  N N   . ALA A 1 97  ? -45.085 -29.641 -14.280 1.000 53.624 ? 123 ALA A N   1 ? 
ATOM   432  C CA  . ALA A 1 97  ? -46.043 -29.851 -15.401 1.000 57.429 ? 123 ALA A CA  1 ? 
ATOM   433  C C   . ALA A 1 97  ? -45.345 -30.375 -16.687 1.000 52.842 ? 123 ALA A C   1 ? 
ATOM   434  O O   . ALA A 1 97  ? -45.843 -31.367 -17.250 1.000 52.784 ? 123 ALA A O   1 ? 
ATOM   435  C CB  . ALA A 1 97  ? -46.759 -28.540 -15.634 1.000 58.417 ? 123 ALA A CB  1 ? 
ATOM   436  N N   . CYS A 1 98  ? -44.184 -29.805 -17.069 1.000 52.921 ? 124 CYS A N   1 ? 
ATOM   437  C CA  . CYS A 1 98  ? -43.337 -30.149 -18.260 1.000 50.790 ? 124 CYS A CA  1 ? 
ATOM   438  C C   . CYS A 1 98  ? -42.509 -31.423 -18.053 1.000 52.909 ? 124 CYS A C   1 ? 
ATOM   439  O O   . CYS A 1 98  ? -41.682 -31.739 -18.935 1.000 53.167 ? 124 CYS A O   1 ? 
ATOM   440  C CB  . CYS A 1 98  ? -42.325 -29.044 -18.552 1.000 58.034 ? 124 CYS A CB  1 ? 
ATOM   441  S SG  . CYS A 1 98  ? -41.442 -28.474 -17.068 1.000 58.443 ? 124 CYS A SG  1 ? 
ATOM   442  N N   . LYS A 1 99  ? -42.661 -32.115 -16.929 1.000 44.301 ? 125 LYS A N   1 ? 
ATOM   443  C CA  . LYS A 1 99  ? -41.801 -33.281 -16.625 1.000 42.829 ? 125 LYS A CA  1 ? 
ATOM   444  C C   . LYS A 1 99  ? -42.075 -34.384 -17.634 1.000 43.671 ? 125 LYS A C   1 ? 
ATOM   445  O O   . LYS A 1 99  ? -43.156 -34.433 -18.191 1.000 46.274 ? 125 LYS A O   1 ? 
ATOM   446  C CB  . LYS A 1 99  ? -41.984 -33.797 -15.199 1.000 50.866 ? 125 LYS A CB  1 ? 
ATOM   447  C CG  . LYS A 1 99  ? -42.792 -35.078 -15.068 1.000 56.584 ? 125 LYS A CG  1 ? 
ATOM   448  C CD  . LYS A 1 99  ? -44.261 -34.822 -15.004 1.000 63.232 ? 125 LYS A CD  1 ? 
ATOM   449  C CE  . LYS A 1 99  ? -45.074 -36.087 -15.146 1.000 67.989 ? 125 LYS A CE  1 ? 
ATOM   450  N NZ  . LYS A 1 99  ? -46.490 -35.802 -14.842 1.000 69.529 ? 125 LYS A NZ  1 ? 
ATOM   451  N N   . ILE A 1 100 ? -41.071 -35.198 -17.900 1.000 42.835 ? 126 ILE A N   1 ? 
ATOM   452  C CA  . ILE A 1 100 ? -41.167 -36.407 -18.750 1.000 44.102 ? 126 ILE A CA  1 ? 
ATOM   453  C C   . ILE A 1 100 ? -40.979 -37.563 -17.791 1.000 45.467 ? 126 ILE A C   1 ? 
ATOM   454  O O   . ILE A 1 100 ? -39.936 -37.592 -17.122 1.000 39.377 ? 126 ILE A O   1 ? 
ATOM   455  C CB  . ILE A 1 100 ? -40.083 -36.432 -19.852 1.000 49.903 ? 126 ILE A CB  1 ? 
ATOM   456  C CG1 . ILE A 1 100 ? -40.234 -35.281 -20.861 1.000 53.937 ? 126 ILE A CG1 1 ? 
ATOM   457  C CG2 . ILE A 1 100 ? -40.020 -37.794 -20.525 1.000 51.990 ? 126 ILE A CG2 1 ? 
ATOM   458  C CD1 . ILE A 1 100 ? -41.669 -34.883 -21.174 1.000 59.008 ? 126 ILE A CD1 1 ? 
ATOM   459  N N   . THR A 1 101 ? -41.920 -38.496 -17.785 1.000 37.906 ? 127 THR A N   1 ? 
ATOM   460  C CA  . THR A 1 101 ? -41.812 -39.741 -17.005 1.000 37.853 ? 127 THR A CA  1 ? 
ATOM   461  C C   . THR A 1 101 ? -40.921 -40.687 -17.786 1.000 35.793 ? 127 THR A C   1 ? 
ATOM   462  O O   . THR A 1 101 ? -41.317 -41.097 -18.850 1.000 39.157 ? 127 THR A O   1 ? 
ATOM   463  C CB  . THR A 1 101 ? -43.202 -40.308 -16.685 1.000 38.779 ? 127 THR A CB  1 ? 
ATOM   464  O OG1 . THR A 1 101 ? -43.886 -39.273 -15.995 1.000 35.530 ? 127 THR A OG1 1 ? 
ATOM   465  C CG2 . THR A 1 101 ? -43.163 -41.560 -15.844 1.000 38.778 ? 127 THR A CG2 1 ? 
ATOM   466  N N   . ASP A 1 102 ? -39.729 -40.998 -17.275 1.000 41.230 ? 128 ASP A N   1 ? 
ATOM   467  C CA  . ASP A 1 102 ? -38.864 -42.046 -17.867 1.000 41.004 ? 128 ASP A CA  1 ? 
ATOM   468  C C   . ASP A 1 102 ? -38.005 -42.670 -16.758 1.000 47.890 ? 128 ASP A C   1 ? 
ATOM   469  O O   . ASP A 1 102 ? -36.844 -42.199 -16.504 1.000 37.910 ? 128 ASP A O   1 ? 
ATOM   470  C CB  . ASP A 1 102 ? -38.067 -41.469 -19.039 1.000 39.763 ? 128 ASP A CB  1 ? 
ATOM   471  C CG  . ASP A 1 102 ? -37.348 -42.509 -19.865 1.000 41.400 ? 128 ASP A CG  1 ? 
ATOM   472  O OD1 . ASP A 1 102 ? -37.254 -43.690 -19.437 1.000 40.821 ? 128 ASP A OD1 1 ? 
ATOM   473  O OD2 . ASP A 1 102 ? -36.905 -42.134 -20.967 1.000 49.937 ? 128 ASP A OD2 1 ? 
ATOM   474  N N   . ALA A 1 103 ? -38.543 -43.701 -16.121 1.000 48.639 ? 129 ALA A N   1 ? 
ATOM   475  C CA  . ALA A 1 103 ? -37.886 -44.355 -14.976 1.000 43.625 ? 129 ALA A CA  1 ? 
ATOM   476  C C   . ALA A 1 103 ? -36.552 -44.936 -15.444 1.000 38.980 ? 129 ALA A C   1 ? 
ATOM   477  O O   . ALA A 1 103 ? -35.569 -44.798 -14.700 1.000 37.452 ? 129 ALA A O   1 ? 
ATOM   478  C CB  . ALA A 1 103 ? -38.782 -45.397 -14.364 1.000 40.982 ? 129 ALA A CB  1 ? 
ATOM   479  N N   . SER A 1 104 ? -36.514 -45.623 -16.577 1.000 37.962 ? 130 SER A N   1 ? 
ATOM   480  C CA  . SER A 1 104 ? -35.330 -46.442 -16.951 1.000 41.786 ? 130 SER A CA  1 ? 
ATOM   481  C C   . SER A 1 104 ? -34.131 -45.512 -17.224 1.000 44.963 ? 130 SER A C   1 ? 
ATOM   482  O O   . SER A 1 104 ? -32.993 -45.900 -16.857 1.000 40.907 ? 130 SER A O   1 ? 
ATOM   483  C CB  . SER A 1 104 ? -35.585 -47.378 -18.087 1.000 40.810 ? 130 SER A CB  1 ? 
ATOM   484  O OG  . SER A 1 104 ? -35.746 -46.674 -19.304 1.000 46.280 ? 130 SER A OG  1 ? 
ATOM   485  N N   . ARG A 1 105 ? -34.362 -44.337 -17.829 1.000 41.102 ? 131 ARG A N   1 ? 
ATOM   486  C CA  . ARG A 1 105 ? -33.281 -43.369 -18.135 1.000 42.995 ? 131 ARG A CA  1 ? 
ATOM   487  C C   . ARG A 1 105 ? -32.714 -42.800 -16.820 1.000 38.402 ? 131 ARG A C   1 ? 
ATOM   488  O O   . ARG A 1 105 ? -31.476 -42.794 -16.703 1.000 42.743 ? 131 ARG A O   1 ? 
ATOM   489  C CB  . ARG A 1 105 ? -33.760 -42.237 -19.051 1.000 46.428 ? 131 ARG A CB  1 ? 
ATOM   490  C CG  . ARG A 1 105 ? -32.654 -41.228 -19.322 1.000 53.144 ? 131 ARG A CG  1 ? 
ATOM   491  C CD  . ARG A 1 105 ? -32.800 -40.498 -20.629 1.000 68.493 ? 131 ARG A CD  1 ? 
ATOM   492  N NE  . ARG A 1 105 ? -31.661 -40.829 -21.477 1.000 72.658 ? 131 ARG A NE  1 ? 
ATOM   493  C CZ  . ARG A 1 105 ? -30.825 -39.933 -21.982 1.000 72.735 ? 131 ARG A CZ  1 ? 
ATOM   494  N NH1 . ARG A 1 105 ? -31.010 -38.636 -21.751 1.000 62.146 ? 131 ARG A NH1 1 ? 
ATOM   495  N NH2 . ARG A 1 105 ? -29.788 -40.354 -22.694 1.000 78.031 ? 131 ARG A NH2 1 ? 
ATOM   496  N N   . CYS A 1 106 ? -33.567 -42.319 -15.906 1.000 40.788 ? 132 CYS A N   1 ? 
ATOM   497  C CA  . CYS A 1 106 ? -33.169 -41.776 -14.569 1.000 46.367 ? 132 CYS A CA  1 ? 
ATOM   498  C C   . CYS A 1 106 ? -32.375 -42.812 -13.794 1.000 41.207 ? 132 CYS A C   1 ? 
ATOM   499  O O   . CYS A 1 106 ? -31.371 -42.434 -13.189 1.000 39.073 ? 132 CYS A O   1 ? 
ATOM   500  C CB  . CYS A 1 106 ? -34.338 -41.455 -13.661 1.000 52.354 ? 132 CYS A CB  1 ? 
ATOM   501  S SG  . CYS A 1 106 ? -35.351 -40.103 -14.280 1.000 63.176 ? 132 CYS A SG  1 ? 
ATOM   502  N N   . THR A 1 107 ? -32.860 -44.060 -13.791 1.000 45.746 ? 133 THR A N   1 ? 
ATOM   503  C CA  . THR A 1 107 ? -32.221 -45.216 -13.105 1.000 44.496 ? 133 THR A CA  1 ? 
ATOM   504  C C   . THR A 1 107 ? -30.820 -45.448 -13.666 1.000 43.456 ? 133 THR A C   1 ? 
ATOM   505  O O   . THR A 1 107 ? -29.865 -45.603 -12.845 1.000 43.709 ? 133 THR A O   1 ? 
ATOM   506  C CB  . THR A 1 107 ? -33.028 -46.513 -13.253 1.000 48.326 ? 133 THR A CB  1 ? 
ATOM   507  O OG1 . THR A 1 107 ? -34.312 -46.248 -12.703 1.000 49.409 ? 133 THR A OG1 1 ? 
ATOM   508  C CG2 . THR A 1 107 ? -32.386 -47.682 -12.538 1.000 48.804 ? 133 THR A CG2 1 ? 
ATOM   509  N N   . THR A 1 108 ? -30.684 -45.526 -14.992 1.000 36.864 ? 134 THR A N   1 ? 
ATOM   510  C CA  . THR A 1 108 ? -29.368 -45.694 -15.654 1.000 40.252 ? 134 THR A CA  1 ? 
ATOM   511  C C   . THR A 1 108 ? -28.459 -44.521 -15.313 1.000 41.638 ? 134 THR A C   1 ? 
ATOM   512  O O   . THR A 1 108 ? -27.262 -44.790 -15.016 1.000 42.181 ? 134 THR A O   1 ? 
ATOM   513  C CB  . THR A 1 108 ? -29.527 -45.880 -17.164 1.000 44.235 ? 134 THR A CB  1 ? 
ATOM   514  O OG1 . THR A 1 108 ? -30.454 -46.950 -17.228 1.000 41.280 ? 134 THR A OG1 1 ? 
ATOM   515  C CG2 . THR A 1 108 ? -28.261 -46.265 -17.882 1.000 41.184 ? 134 THR A CG2 1 ? 
ATOM   516  N N   . ALA A 1 109 ? -28.983 -43.291 -15.368 1.000 37.684 ? 135 ALA A N   1 ? 
ATOM   517  C CA  . ALA A 1 109 ? -28.175 -42.090 -15.101 1.000 38.092 ? 135 ALA A CA  1 ? 
ATOM   518  C C   . ALA A 1 109 ? -27.665 -42.206 -13.660 1.000 43.987 ? 135 ALA A C   1 ? 
ATOM   519  O O   . ALA A 1 109 ? -26.471 -42.030 -13.460 1.000 35.492 ? 135 ALA A O   1 ? 
ATOM   520  C CB  . ALA A 1 109 ? -28.962 -40.818 -15.330 1.000 36.448 ? 135 ALA A CB  1 ? 
ATOM   521  N N   . VAL A 1 110 ? -28.541 -42.463 -12.688 1.000 37.144 ? 136 VAL A N   1 ? 
ATOM   522  C CA  . VAL A 1 110 ? -28.125 -42.497 -11.255 1.000 38.806 ? 136 VAL A CA  1 ? 
ATOM   523  C C   . VAL A 1 110 ? -27.084 -43.596 -11.047 1.000 41.326 ? 136 VAL A C   1 ? 
ATOM   524  O O   . VAL A 1 110 ? -26.049 -43.341 -10.337 1.000 38.441 ? 136 VAL A O   1 ? 
ATOM   525  C CB  . VAL A 1 110 ? -29.329 -42.624 -10.315 1.000 44.718 ? 136 VAL A CB  1 ? 
ATOM   526  C CG1 . VAL A 1 110 ? -28.904 -43.105 -8.928  1.000 45.866 ? 136 VAL A CG1 1 ? 
ATOM   527  C CG2 . VAL A 1 110 ? -30.057 -41.302 -10.258 1.000 42.332 ? 136 VAL A CG2 1 ? 
ATOM   528  N N   . GLY A 1 111 ? -27.307 -44.759 -11.652 1.000 42.880 ? 137 GLY A N   1 ? 
ATOM   529  C CA  . GLY A 1 111 ? -26.346 -45.878 -11.634 1.000 43.075 ? 137 GLY A CA  1 ? 
ATOM   530  C C   . GLY A 1 111 ? -24.984 -45.467 -12.194 1.000 45.787 ? 137 GLY A C   1 ? 
ATOM   531  O O   . GLY A 1 111 ? -23.988 -45.772 -11.571 1.000 40.211 ? 137 GLY A O   1 ? 
ATOM   532  N N   . ASP A 1 112 ? -24.956 -44.760 -13.321 1.000 41.159 ? 138 ASP A N   1 ? 
ATOM   533  C CA  . ASP A 1 112 ? -23.722 -44.289 -13.980 1.000 41.570 ? 138 ASP A CA  1 ? 
ATOM   534  C C   . ASP A 1 112 ? -23.052 -43.258 -13.077 1.000 38.547 ? 138 ASP A C   1 ? 
ATOM   535  O O   . ASP A 1 112 ? -21.802 -43.262 -13.008 1.000 40.110 ? 138 ASP A O   1 ? 
ATOM   536  C CB  . ASP A 1 112 ? -24.014 -43.747 -15.383 1.000 44.273 ? 138 ASP A CB  1 ? 
ATOM   537  C CG  . ASP A 1 112 ? -24.303 -44.860 -16.384 1.000 45.998 ? 138 ASP A CG  1 ? 
ATOM   538  O OD1 . ASP A 1 112 ? -24.153 -46.042 -16.015 1.000 42.918 ? 138 ASP A OD1 1 ? 
ATOM   539  O OD2 . ASP A 1 112 ? -24.665 -44.538 -17.535 1.000 43.808 ? 138 ASP A OD2 1 ? 
ATOM   540  N N   . MET A 1 113 ? -23.851 -42.445 -12.404 1.000 40.276 ? 139 MET A N   1 ? 
ATOM   541  C CA  . MET A 1 113 ? -23.331 -41.440 -11.443 1.000 44.016 ? 139 MET A CA  1 ? 
ATOM   542  C C   . MET A 1 113 ? -22.606 -42.179 -10.299 1.000 45.726 ? 139 MET A C   1 ? 
ATOM   543  O O   . MET A 1 113 ? -21.498 -41.770 -9.966  1.000 39.208 ? 139 MET A O   1 ? 
ATOM   544  C CB  . MET A 1 113 ? -24.446 -40.554 -10.891 1.000 40.421 ? 139 MET A CB  1 ? 
ATOM   545  C CG  . MET A 1 113 ? -24.133 -40.015 -9.482  1.000 45.053 ? 139 MET A CG  1 ? 
ATOM   546  S SD  . MET A 1 113 ? -25.294 -38.767 -8.873  1.000 46.677 ? 139 MET A SD  1 ? 
ATOM   547  C CE  . MET A 1 113 ? -26.405 -39.792 -7.924  1.000 49.573 ? 139 MET A CE  1 ? 
ATOM   548  N N   . GLN A 1 114 ? -23.175 -43.260 -9.760  1.000 43.482 ? 140 GLN A N   1 ? 
ATOM   549  C CA  . GLN A 1 114 ? -22.526 -44.067 -8.679  1.000 49.882 ? 140 GLN A CA  1 ? 
ATOM   550  C C   . GLN A 1 114 ? -21.202 -44.682 -9.177  1.000 48.705 ? 140 GLN A C   1 ? 
ATOM   551  O O   . GLN A 1 114 ? -20.214 -44.657 -8.416  1.000 45.520 ? 140 GLN A O   1 ? 
ATOM   552  C CB  . GLN A 1 114 ? -23.477 -45.160 -8.164  1.000 54.437 ? 140 GLN A CB  1 ? 
ATOM   553  C CG  . GLN A 1 114 ? -22.931 -45.988 -6.989  1.000 62.269 ? 140 GLN A CG  1 ? 
ATOM   554  C CD  . GLN A 1 114 ? -22.677 -45.203 -5.717  1.000 71.411 ? 140 GLN A CD  1 ? 
ATOM   555  O OE1 . GLN A 1 114 ? -23.607 -44.643 -5.128  1.000 77.652 ? 140 GLN A OE1 1 ? 
ATOM   556  N NE2 . GLN A 1 114 ? -21.409 -45.117 -5.301  1.000 57.244 ? 140 GLN A NE2 1 ? 
ATOM   557  N N   . ILE A 1 115 ? -21.183 -45.264 -10.377 1.000 40.408 ? 141 ILE A N   1 ? 
ATOM   558  C CA  . ILE A 1 115 ? -19.958 -45.840 -10.987 1.000 42.399 ? 141 ILE A CA  1 ? 
ATOM   559  C C   . ILE A 1 115 ? -18.899 -44.746 -11.102 1.000 46.398 ? 141 ILE A C   1 ? 
ATOM   560  O O   . ILE A 1 115 ? -17.716 -45.027 -10.783 1.000 44.813 ? 141 ILE A O   1 ? 
ATOM   561  C CB  . ILE A 1 115 ? -20.270 -46.480 -12.349 1.000 47.486 ? 141 ILE A CB  1 ? 
ATOM   562  C CG1 . ILE A 1 115 ? -21.160 -47.715 -12.193 1.000 49.244 ? 141 ILE A CG1 1 ? 
ATOM   563  C CG2 . ILE A 1 115 ? -19.002 -46.778 -13.127 1.000 43.411 ? 141 ILE A CG2 1 ? 
ATOM   564  C CD1 . ILE A 1 115 ? -21.857 -48.119 -13.485 1.000 48.921 ? 141 ILE A CD1 1 ? 
ATOM   565  N N   . ALA A 1 116 ? -19.296 -43.546 -11.519 1.000 40.792 ? 142 ALA A N   1 ? 
ATOM   566  C CA  . ALA A 1 116 ? -18.374 -42.400 -11.679 1.000 39.672 ? 142 ALA A CA  1 ? 
ATOM   567  C C   . ALA A 1 116 ? -17.814 -42.015 -10.306 1.000 37.949 ? 142 ALA A C   1 ? 
ATOM   568  O O   . ALA A 1 116 ? -16.572 -41.879 -10.163 1.000 36.587 ? 142 ALA A O   1 ? 
ATOM   569  C CB  . ALA A 1 116 ? -19.085 -41.239 -12.321 1.000 40.515 ? 142 ALA A CB  1 ? 
ATOM   570  N N   . TYR A 1 117 ? -18.692 -41.855 -9.327  1.000 32.264 ? 143 TYR A N   1 ? 
ATOM   571  C CA  . TYR A 1 117 ? -18.307 -41.530 -7.940  1.000 40.595 ? 143 TYR A CA  1 ? 
ATOM   572  C C   . TYR A 1 117 ? -17.229 -42.519 -7.447  1.000 43.279 ? 143 TYR A C   1 ? 
ATOM   573  O O   . TYR A 1 117 ? -16.221 -42.032 -6.965  1.000 37.523 ? 143 TYR A O   1 ? 
ATOM   574  C CB  . TYR A 1 117 ? -19.524 -41.513 -7.024  1.000 40.822 ? 143 TYR A CB  1 ? 
ATOM   575  C CG  . TYR A 1 117 ? -19.107 -41.214 -5.623  1.000 37.607 ? 143 TYR A CG  1 ? 
ATOM   576  C CD1 . TYR A 1 117 ? -18.668 -42.227 -4.786  1.000 37.017 ? 143 TYR A CD1 1 ? 
ATOM   577  C CD2 . TYR A 1 117 ? -19.036 -39.910 -5.177  1.000 35.260 ? 143 TYR A CD2 1 ? 
ATOM   578  C CE1 . TYR A 1 117 ? -18.178 -41.938 -3.522  1.000 40.038 ? 143 TYR A CE1 1 ? 
ATOM   579  C CE2 . TYR A 1 117 ? -18.563 -39.614 -3.917  1.000 36.298 ? 143 TYR A CE2 1 ? 
ATOM   580  C CZ  . TYR A 1 117 ? -18.122 -40.623 -3.086  1.000 38.203 ? 143 TYR A CZ  1 ? 
ATOM   581  O OH  . TYR A 1 117 ? -17.676 -40.318 -1.830  1.000 36.790 ? 143 TYR A OH  1 ? 
ATOM   582  N N   . ASP A 1 118 ? -17.442 -43.836 -7.596  1.000 42.929 ? 144 ASP A N   1 ? 
ATOM   583  C CA  . ASP A 1 118 ? -16.523 -44.914 -7.137  1.000 42.537 ? 144 ASP A CA  1 ? 
ATOM   584  C C   . ASP A 1 118 ? -15.238 -44.866 -7.970  1.000 42.723 ? 144 ASP A C   1 ? 
ATOM   585  O O   . ASP A 1 118 ? -14.134 -45.006 -7.368  1.000 43.428 ? 144 ASP A O   1 ? 
ATOM   586  C CB  . ASP A 1 118 ? -17.199 -46.295 -7.183  1.000 40.049 ? 144 ASP A CB  1 ? 
ATOM   587  C CG  . ASP A 1 118 ? -18.372 -46.410 -6.212  1.000 44.775 ? 144 ASP A CG  1 ? 
ATOM   588  O OD1 . ASP A 1 118 ? -18.442 -45.591 -5.248  1.000 46.519 ? 144 ASP A OD1 1 ? 
ATOM   589  O OD2 . ASP A 1 118 ? -19.236 -47.286 -6.441  1.000 47.972 ? 144 ASP A OD2 1 ? 
ATOM   590  N N   . ASN A 1 119 ? -15.344 -44.622 -9.287  1.000 39.809 ? 145 ASN A N   1 ? 
ATOM   591  C CA  . ASN A 1 119 ? -14.155 -44.503 -10.162 1.000 42.987 ? 145 ASN A CA  1 ? 
ATOM   592  C C   . ASN A 1 119 ? -13.282 -43.355 -9.636  1.000 44.700 ? 145 ASN A C   1 ? 
ATOM   593  O O   . ASN A 1 119 ? -12.054 -43.599 -9.436  1.000 42.152 ? 145 ASN A O   1 ? 
ATOM   594  C CB  . ASN A 1 119 ? -14.521 -44.350 -11.633 1.000 48.884 ? 145 ASN A CB  1 ? 
ATOM   595  C CG  . ASN A 1 119 ? -13.305 -44.156 -12.519 1.000 55.638 ? 145 ASN A CG  1 ? 
ATOM   596  O OD1 . ASN A 1 119 ? -12.897 -43.029 -12.796 1.000 57.365 ? 145 ASN A OD1 1 ? 
ATOM   597  N ND2 . ASN A 1 119 ? -12.702 -45.245 -12.965 1.000 52.462 ? 145 ASN A ND2 1 ? 
ATOM   598  N N   . ALA A 1 120 ? -13.872 -42.172 -9.394  1.000 38.989 ? 146 ALA A N   1 ? 
ATOM   599  C CA  . ALA A 1 120 ? -13.172 -40.959 -8.929  1.000 38.286 ? 146 ALA A CA  1 ? 
ATOM   600  C C   . ALA A 1 120 ? -12.572 -41.183 -7.536  1.000 42.679 ? 146 ALA A C   1 ? 
ATOM   601  O O   . ALA A 1 120 ? -11.378 -40.892 -7.353  1.000 40.864 ? 146 ALA A O   1 ? 
ATOM   602  C CB  . ALA A 1 120 ? -14.098 -39.770 -8.929  1.000 37.896 ? 146 ALA A CB  1 ? 
ATOM   603  N N   . ALA A 1 121 ? -13.370 -41.638 -6.571  1.000 41.189 ? 147 ALA A N   1 ? 
ATOM   604  C CA  . ALA A 1 121 ? -12.884 -41.977 -5.210  1.000 43.614 ? 147 ALA A CA  1 ? 
ATOM   605  C C   . ALA A 1 121 ? -11.799 -43.080 -5.228  1.000 44.484 ? 147 ALA A C   1 ? 
ATOM   606  O O   . ALA A 1 121 ? -10.969 -43.110 -4.300  1.000 39.201 ? 147 ALA A O   1 ? 
ATOM   607  C CB  . ALA A 1 121 ? -14.025 -42.383 -4.332  1.000 41.092 ? 147 ALA A CB  1 ? 
ATOM   608  N N   . GLY A 1 122 ? -11.798 -43.971 -6.218  1.000 46.084 ? 148 GLY A N   1 ? 
ATOM   609  C CA  . GLY A 1 122 ? -10.905 -45.139 -6.246  1.000 47.248 ? 148 GLY A CA  1 ? 
ATOM   610  C C   . GLY A 1 122 ? -9.540  -44.821 -6.838  1.000 47.674 ? 148 GLY A C   1 ? 
ATOM   611  O O   . GLY A 1 122 ? -8.724  -45.714 -6.784  1.000 50.783 ? 148 GLY A O   1 ? 
ATOM   612  N N   . ARG A 1 123 ? -9.307  -43.633 -7.426  1.000 44.360 ? 149 ARG A N   1 ? 
ATOM   613  C CA  . ARG A 1 123 ? -8.020  -43.304 -8.108  1.000 48.195 ? 149 ARG A CA  1 ? 
ATOM   614  C C   . ARG A 1 123 ? -6.917  -43.373 -7.050  1.000 48.984 ? 149 ARG A C   1 ? 
ATOM   615  O O   . ARG A 1 123 ? -7.198  -42.978 -5.894  1.000 47.505 ? 149 ARG A O   1 ? 
ATOM   616  C CB  . ARG A 1 123 ? -8.049  -41.937 -8.806  1.000 47.991 ? 149 ARG A CB  1 ? 
ATOM   617  C CG  . ARG A 1 123 ? -9.084  -41.827 -9.923  1.000 49.310 ? 149 ARG A CG  1 ? 
ATOM   618  C CD  . ARG A 1 123 ? -8.955  -42.892 -10.996 1.000 48.869 ? 149 ARG A CD  1 ? 
ATOM   619  N NE  . ARG A 1 123 ? -9.897  -42.662 -12.081 1.000 46.376 ? 149 ARG A NE  1 ? 
ATOM   620  C CZ  . ARG A 1 123 ? -9.745  -41.788 -13.082 1.000 45.435 ? 149 ARG A CZ  1 ? 
ATOM   621  N NH1 . ARG A 1 123 ? -8.664  -41.033 -13.196 1.000 44.108 ? 149 ARG A NH1 1 ? 
ATOM   622  N NH2 . ARG A 1 123 ? -10.702 -41.660 -13.984 1.000 47.464 ? 149 ARG A NH2 1 ? 
ATOM   623  N N   . LEU A 1 124 ? -5.733  -43.887 -7.412  1.000 50.978 ? 150 LEU A N   1 ? 
ATOM   624  C CA  . LEU A 1 124 ? -4.618  -44.083 -6.439  1.000 49.877 ? 150 LEU A CA  1 ? 
ATOM   625  C C   . LEU A 1 124 ? -3.448  -43.173 -6.810  1.000 49.700 ? 150 LEU A C   1 ? 
ATOM   626  O O   . LEU A 1 124 ? -3.388  -42.665 -7.961  1.000 40.057 ? 150 LEU A O   1 ? 
ATOM   627  C CB  . LEU A 1 124 ? -4.157  -45.543 -6.420  1.000 53.778 ? 150 LEU A CB  1 ? 
ATOM   628  C CG  . LEU A 1 124 ? -5.232  -46.621 -6.332  1.000 54.752 ? 150 LEU A CG  1 ? 
ATOM   629  C CD1 . LEU A 1 124 ? -4.666  -47.945 -6.804  1.000 55.413 ? 150 LEU A CD1 1 ? 
ATOM   630  C CD2 . LEU A 1 124 ? -5.811  -46.733 -4.922  1.000 54.956 ? 150 LEU A CD2 1 ? 
ATOM   631  N N   . ASN A 1 125 ? -2.521  -42.992 -5.871  1.000 52.680 ? 151 ASN A N   1 ? 
ATOM   632  C CA  . ASN A 1 125 ? -1.215  -42.338 -6.148  1.000 48.546 ? 151 ASN A CA  1 ? 
ATOM   633  C C   . ASN A 1 125 ? -1.484  -40.864 -6.395  1.000 43.185 ? 151 ASN A C   1 ? 
ATOM   634  O O   . ASN A 1 125 ? -1.188  -40.307 -7.438  1.000 43.089 ? 151 ASN A O   1 ? 
ATOM   635  C CB  . ASN A 1 125 ? -0.470  -43.010 -7.305  1.000 49.469 ? 151 ASN A CB  1 ? 
ATOM   636  C CG  . ASN A 1 125 ? -0.289  -44.497 -7.083  1.000 52.904 ? 151 ASN A CG  1 ? 
ATOM   637  O OD1 . ASN A 1 125 ? -0.186  -44.968 -5.957  1.000 68.474 ? 151 ASN A OD1 1 ? 
ATOM   638  N ND2 . ASN A 1 125 ? -0.245  -45.257 -8.153  1.000 62.282 ? 151 ASN A ND2 1 ? 
ATOM   639  N N   . PRO A 1 126 ? -2.099  -40.162 -5.438  1.000 42.261 ? 152 PRO A N   1 ? 
ATOM   640  C CA  . PRO A 1 126 ? -2.330  -38.746 -5.659  1.000 39.476 ? 152 PRO A CA  1 ? 
ATOM   641  C C   . PRO A 1 126 ? -1.011  -38.016 -5.927  1.000 42.713 ? 152 PRO A C   1 ? 
ATOM   642  O O   . PRO A 1 126 ? -0.053  -38.401 -5.383  1.000 41.072 ? 152 PRO A O   1 ? 
ATOM   643  C CB  . PRO A 1 126 ? -2.893  -38.284 -4.325  1.000 40.334 ? 152 PRO A CB  1 ? 
ATOM   644  C CG  . PRO A 1 126 ? -2.531  -39.374 -3.339  1.000 41.360 ? 152 PRO A CG  1 ? 
ATOM   645  C CD  . PRO A 1 126 ? -2.505  -40.657 -4.118  1.000 40.637 ? 152 PRO A CD  1 ? 
ATOM   646  N N   . ASP A 1 127 ? -1.085  -36.878 -6.598  1.000 45.363 ? 153 ASP A N   1 ? 
ATOM   647  C CA  . ASP A 1 127 ? -0.002  -35.900 -6.801  1.000 45.153 ? 153 ASP A CA  1 ? 
ATOM   648  C C   . ASP A 1 127 ? 0.089   -34.972 -5.599  1.000 49.420 ? 153 ASP A C   1 ? 
ATOM   649  O O   . ASP A 1 127 ? 1.176   -34.432 -5.377  1.000 42.896 ? 153 ASP A O   1 ? 
ATOM   650  C CB  . ASP A 1 127 ? -0.270  -35.109 -8.079  1.000 44.572 ? 153 ASP A CB  1 ? 
ATOM   651  C CG  . ASP A 1 127 ? -0.250  -36.039 -9.274  1.000 48.383 ? 153 ASP A CG  1 ? 
ATOM   652  O OD1 . ASP A 1 127 ? 0.765   -36.723 -9.428  1.000 48.540 ? 153 ASP A OD1 1 ? 
ATOM   653  O OD2 . ASP A 1 127 ? -1.260  -36.116 -10.014 1.000 39.442 ? 153 ASP A OD2 1 ? 
ATOM   654  N N   . PHE A 1 128 ? -1.027  -34.709 -4.918  1.000 43.523 ? 154 PHE A N   1 ? 
ATOM   655  C CA  . PHE A 1 128 ? -1.086  -33.844 -3.716  1.000 42.669 ? 154 PHE A CA  1 ? 
ATOM   656  C C   . PHE A 1 128 ? -1.946  -34.492 -2.629  1.000 46.480 ? 154 PHE A C   1 ? 
ATOM   657  O O   . PHE A 1 128 ? -2.980  -35.137 -2.945  1.000 45.378 ? 154 PHE A O   1 ? 
ATOM   658  C CB  . PHE A 1 128 ? -1.590  -32.453 -4.070  1.000 40.285 ? 154 PHE A CB  1 ? 
ATOM   659  C CG  . PHE A 1 128 ? -0.876  -31.807 -5.223  1.000 45.739 ? 154 PHE A CG  1 ? 
ATOM   660  C CD1 . PHE A 1 128 ? -1.314  -31.980 -6.531  1.000 41.441 ? 154 PHE A CD1 1 ? 
ATOM   661  C CD2 . PHE A 1 128 ? 0.228   -30.993 -5.003  1.000 49.031 ? 154 PHE A CD2 1 ? 
ATOM   662  C CE1 . PHE A 1 128 ? -0.626  -31.411 -7.595  1.000 43.482 ? 154 PHE A CE1 1 ? 
ATOM   663  C CE2 . PHE A 1 128 ? 0.893   -30.394 -6.066  1.000 44.960 ? 154 PHE A CE2 1 ? 
ATOM   664  C CZ  . PHE A 1 128 ? 0.462   -30.594 -7.365  1.000 44.868 ? 154 PHE A CZ  1 ? 
ATOM   665  N N   . LEU A 1 129 ? -1.537  -34.318 -1.370  1.000 41.130 ? 155 LEU A N   1 ? 
ATOM   666  C CA  . LEU A 1 129 ? -2.322  -34.758 -0.194  1.000 41.933 ? 155 LEU A CA  1 ? 
ATOM   667  C C   . LEU A 1 129 ? -2.323  -33.624 0.828   1.000 48.607 ? 155 LEU A C   1 ? 
ATOM   668  O O   . LEU A 1 129 ? -1.225  -33.214 1.265   1.000 39.878 ? 155 LEU A O   1 ? 
ATOM   669  C CB  . LEU A 1 129 ? -1.742  -36.053 0.375   1.000 43.811 ? 155 LEU A CB  1 ? 
ATOM   670  C CG  . LEU A 1 129 ? -2.424  -36.564 1.633   1.000 44.358 ? 155 LEU A CG  1 ? 
ATOM   671  C CD1 . LEU A 1 129 ? -3.879  -36.902 1.336   1.000 42.026 ? 155 LEU A CD1 1 ? 
ATOM   672  C CD2 . LEU A 1 129 ? -1.704  -37.775 2.186   1.000 45.342 ? 155 LEU A CD2 1 ? 
ATOM   673  N N   . ASN A 1 130 ? -3.515  -33.120 1.164   1.000 37.449 ? 156 ASN A N   1 ? 
ATOM   674  C CA  . ASN A 1 130 ? -3.757  -32.126 2.239   1.000 41.693 ? 156 ASN A CA  1 ? 
ATOM   675  C C   . ASN A 1 130 ? -3.105  -30.797 1.845   1.000 40.529 ? 156 ASN A C   1 ? 
ATOM   676  O O   . ASN A 1 130 ? -2.706  -30.014 2.731   1.000 42.468 ? 156 ASN A O   1 ? 
ATOM   677  C CB  . ASN A 1 130 ? -3.437  -32.728 3.622   1.000 40.503 ? 156 ASN A CB  1 ? 
ATOM   678  C CG  . ASN A 1 130 ? -4.396  -33.848 3.993   1.000 46.377 ? 156 ASN A CG  1 ? 
ATOM   679  O OD1 . ASN A 1 130 ? -5.600  -33.762 3.707   1.000 42.706 ? 156 ASN A OD1 1 ? 
ATOM   680  N ND2 . ASN A 1 130 ? -3.902  -34.924 4.590   1.000 37.533 ? 156 ASN A ND2 1 ? 
ATOM   681  N N   . LEU A 1 131 ? -3.124  -30.496 0.554   1.000 39.150 ? 157 LEU A N   1 ? 
ATOM   682  C CA  . LEU A 1 131 ? -2.645  -29.203 0.026   1.000 44.236 ? 157 LEU A CA  1 ? 
ATOM   683  C C   . LEU A 1 131 ? -3.298  -28.058 0.808   1.000 47.735 ? 157 LEU A C   1 ? 
ATOM   684  O O   . LEU A 1 131 ? -4.524  -28.113 1.071   1.000 44.327 ? 157 LEU A O   1 ? 
ATOM   685  C CB  . LEU A 1 131 ? -2.960  -29.126 -1.473  1.000 48.680 ? 157 LEU A CB  1 ? 
ATOM   686  C CG  . LEU A 1 131 ? -2.421  -27.872 -2.166  1.000 49.968 ? 157 LEU A CG  1 ? 
ATOM   687  C CD1 . LEU A 1 131 ? -0.907  -27.946 -2.300  1.000 55.611 ? 157 LEU A CD1 1 ? 
ATOM   688  C CD2 . LEU A 1 131 ? -3.042  -27.679 -3.528  1.000 49.839 ? 157 LEU A CD2 1 ? 
ATOM   689  N N   . GLY A 1 132 ? -2.516  -27.029 1.149   1.000 40.489 ? 158 GLY A N   1 ? 
ATOM   690  C CA  . GLY A 1 132 ? -2.964  -25.867 1.933   1.000 41.013 ? 158 GLY A CA  1 ? 
ATOM   691  C C   . GLY A 1 132 ? -3.518  -26.226 3.313   1.000 36.249 ? 158 GLY A C   1 ? 
ATOM   692  O O   . GLY A 1 132 ? -4.065  -25.332 3.967   1.000 39.669 ? 158 GLY A O   1 ? 
ATOM   693  N N   . ALA A 1 133 ? -3.364  -27.473 3.753   1.000 37.306 ? 159 ALA A N   1 ? 
ATOM   694  C CA  . ALA A 1 133 ? -3.909  -27.988 5.021   1.000 44.731 ? 159 ALA A CA  1 ? 
ATOM   695  C C   . ALA A 1 133 ? -5.439  -27.788 5.057   1.000 48.982 ? 159 ALA A C   1 ? 
ATOM   696  O O   . ALA A 1 133 ? -5.966  -27.500 6.145   1.000 48.672 ? 159 ALA A O   1 ? 
ATOM   697  C CB  . ALA A 1 133 ? -3.261  -27.288 6.190   1.000 42.837 ? 159 ALA A CB  1 ? 
ATOM   698  N N   . GLY A 1 134 ? -6.121  -27.897 3.915   1.000 51.588 ? 160 GLY A N   1 ? 
ATOM   699  C CA  . GLY A 1 134 ? -7.597  -27.883 3.850   1.000 46.231 ? 160 GLY A CA  1 ? 
ATOM   700  C C   . GLY A 1 134 ? -8.154  -26.514 3.566   1.000 41.059 ? 160 GLY A C   1 ? 
ATOM   701  O O   . GLY A 1 134 ? -9.385  -26.425 3.453   1.000 43.105 ? 160 GLY A O   1 ? 
ATOM   702  N N   . THR A 1 135 ? -7.309  -25.512 3.331   1.000 44.306 ? 161 THR A N   1 ? 
ATOM   703  C CA  . THR A 1 135 ? -7.737  -24.148 2.910   1.000 43.216 ? 161 THR A CA  1 ? 
ATOM   704  C C   . THR A 1 135 ? -6.855  -23.649 1.745   1.000 50.265 ? 161 THR A C   1 ? 
ATOM   705  O O   . THR A 1 135 ? -5.641  -23.461 1.933   1.000 47.296 ? 161 THR A O   1 ? 
ATOM   706  C CB  . THR A 1 135 ? -7.776  -23.218 4.128   1.000 56.035 ? 161 THR A CB  1 ? 
ATOM   707  O OG1 . THR A 1 135 ? -7.883  -21.919 3.536   1.000 62.910 ? 161 THR A OG1 1 ? 
ATOM   708  C CG2 . THR A 1 135 ? -6.567  -23.362 5.040   1.000 50.568 ? 161 THR A CG2 1 ? 
ATOM   709  N N   . ILE A 1 136 ? -7.424  -23.453 0.549   1.000 45.602 ? 162 ILE A N   1 ? 
ATOM   710  C CA  . ILE A 1 136 ? -6.613  -23.343 -0.704  1.000 37.307 ? 162 ILE A CA  1 ? 
ATOM   711  C C   . ILE A 1 136 ? -6.875  -22.008 -1.371  1.000 36.883 ? 162 ILE A C   1 ? 
ATOM   712  O O   . ILE A 1 136 ? -6.569  -21.871 -2.566  1.000 42.733 ? 162 ILE A O   1 ? 
ATOM   713  C CB  . ILE A 1 136 ? -6.855  -24.541 -1.619  1.000 39.057 ? 162 ILE A CB  1 ? 
ATOM   714  C CG1 . ILE A 1 136 ? -8.330  -24.711 -2.008  1.000 38.944 ? 162 ILE A CG1 1 ? 
ATOM   715  C CG2 . ILE A 1 136 ? -6.346  -25.816 -0.974  1.000 38.574 ? 162 ILE A CG2 1 ? 
ATOM   716  C CD1 . ILE A 1 136 ? -8.485  -25.538 -3.248  1.000 34.717 ? 162 ILE A CD1 1 ? 
ATOM   717  N N   . GLY A 1 137 ? -7.354  -21.025 -0.615  1.000 42.235 ? 163 GLY A N   1 ? 
ATOM   718  C CA  . GLY A 1 137 ? -7.576  -19.668 -1.160  1.000 41.755 ? 163 GLY A CA  1 ? 
ATOM   719  C C   . GLY A 1 137 ? -6.310  -19.161 -1.825  1.000 47.238 ? 163 GLY A C   1 ? 
ATOM   720  O O   . GLY A 1 137 ? -5.267  -19.403 -1.263  1.000 51.968 ? 163 GLY A O   1 ? 
ATOM   721  N N   . GLY A 1 138 ? -6.402  -18.529 -2.993  1.000 51.764 ? 164 GLY A N   1 ? 
ATOM   722  C CA  . GLY A 1 138 ? -5.286  -17.874 -3.705  1.000 52.408 ? 164 GLY A CA  1 ? 
ATOM   723  C C   . GLY A 1 138 ? -4.393  -18.830 -4.501  1.000 55.462 ? 164 GLY A C   1 ? 
ATOM   724  O O   . GLY A 1 138 ? -3.523  -18.349 -5.229  1.000 51.175 ? 164 GLY A O   1 ? 
ATOM   725  N N   . LYS A 1 139 ? -4.579  -20.145 -4.416  1.000 54.719 ? 165 LYS A N   1 ? 
ATOM   726  C CA  . LYS A 1 139 ? -3.699  -21.083 -5.152  1.000 51.823 ? 165 LYS A CA  1 ? 
ATOM   727  C C   . LYS A 1 139 ? -4.052  -21.047 -6.640  1.000 55.446 ? 165 LYS A C   1 ? 
ATOM   728  O O   . LYS A 1 139 ? -5.150  -20.536 -7.019  1.000 50.981 ? 165 LYS A O   1 ? 
ATOM   729  C CB  . LYS A 1 139 ? -3.758  -22.477 -4.517  1.000 56.087 ? 165 LYS A CB  1 ? 
ATOM   730  C CG  . LYS A 1 139 ? -3.355  -22.512 -3.043  1.000 55.643 ? 165 LYS A CG  1 ? 
ATOM   731  C CD  . LYS A 1 139 ? -2.542  -23.722 -2.610  1.000 62.332 ? 165 LYS A CD  1 ? 
ATOM   732  C CE  . LYS A 1 139 ? -1.506  -23.362 -1.557  1.000 67.118 ? 165 LYS A CE  1 ? 
ATOM   733  N NZ  . LYS A 1 139 ? -0.785  -24.556 -1.046  1.000 77.877 ? 165 LYS A NZ  1 ? 
ATOM   734  N N   . THR A 1 140 ? -3.099  -21.493 -7.451  1.000 45.407 ? 166 THR A N   1 ? 
ATOM   735  C CA  . THR A 1 140 ? -3.279  -21.866 -8.868  1.000 47.740 ? 166 THR A CA  1 ? 
ATOM   736  C C   . THR A 1 140 ? -3.072  -23.385 -8.916  1.000 49.511 ? 166 THR A C   1 ? 
ATOM   737  O O   . THR A 1 140 ? -1.986  -23.816 -8.553  1.000 49.075 ? 166 THR A O   1 ? 
ATOM   738  C CB  . THR A 1 140 ? -2.329  -21.072 -9.775  1.000 46.496 ? 166 THR A CB  1 ? 
ATOM   739  O OG1 . THR A 1 140 ? -2.686  -19.687 -9.743  1.000 50.219 ? 166 THR A OG1 1 ? 
ATOM   740  C CG2 . THR A 1 140 ? -2.352  -21.544 -11.210 1.000 47.177 ? 166 THR A CG2 1 ? 
ATOM   741  N N   . LEU A 1 141 ? -4.080  -24.167 -9.309  1.000 44.292 ? 167 LEU A N   1 ? 
ATOM   742  C CA  . LEU A 1 141 ? -4.028  -25.659 -9.261  1.000 42.586 ? 167 LEU A CA  1 ? 
ATOM   743  C C   . LEU A 1 141 ? -3.705  -26.214 -10.636 1.000 45.504 ? 167 LEU A C   1 ? 
ATOM   744  O O   . LEU A 1 141 ? -4.494  -25.972 -11.558 1.000 51.387 ? 167 LEU A O   1 ? 
ATOM   745  C CB  . LEU A 1 141 ? -5.385  -26.177 -8.785  1.000 42.440 ? 167 LEU A CB  1 ? 
ATOM   746  C CG  . LEU A 1 141 ? -5.830  -25.587 -7.457  1.000 44.720 ? 167 LEU A CG  1 ? 
ATOM   747  C CD1 . LEU A 1 141 ? -7.298  -25.922 -7.173  1.000 45.456 ? 167 LEU A CD1 1 ? 
ATOM   748  C CD2 . LEU A 1 141 ? -4.908  -26.086 -6.359  1.000 44.169 ? 167 LEU A CD2 1 ? 
ATOM   749  N N   . THR A 1 142 ? -2.595  -26.943 -10.746 1.000 41.550 ? 168 THR A N   1 ? 
ATOM   750  C CA  . THR A 1 142 ? -2.099  -27.547 -11.993 1.000 40.619 ? 168 THR A CA  1 ? 
ATOM   751  C C   . THR A 1 142 ? -2.642  -28.968 -12.045 1.000 39.460 ? 168 THR A C   1 ? 
ATOM   752  O O   . THR A 1 142 ? -3.032  -29.532 -11.024 1.000 45.608 ? 168 THR A O   1 ? 
ATOM   753  C CB  . THR A 1 142 ? -0.549  -27.505 -12.065 1.000 46.349 ? 168 THR A CB  1 ? 
ATOM   754  O OG1 . THR A 1 142 ? -0.037  -28.201 -10.930 1.000 40.688 ? 168 THR A OG1 1 ? 
ATOM   755  C CG2 . THR A 1 142 ? 0.048   -26.118 -12.065 1.000 42.988 ? 168 THR A CG2 1 ? 
ATOM   756  N N   . PRO A 1 143 ? -2.671  -29.577 -13.244 1.000 41.425 ? 169 PRO A N   1 ? 
ATOM   757  C CA  . PRO A 1 143 ? -3.313  -30.870 -13.446 1.000 44.479 ? 169 PRO A CA  1 ? 
ATOM   758  C C   . PRO A 1 143 ? -2.809  -31.981 -12.535 1.000 47.230 ? 169 PRO A C   1 ? 
ATOM   759  O O   . PRO A 1 143 ? -1.664  -32.036 -12.196 1.000 48.097 ? 169 PRO A O   1 ? 
ATOM   760  C CB  . PRO A 1 143 ? -3.004  -31.219 -14.909 1.000 43.566 ? 169 PRO A CB  1 ? 
ATOM   761  C CG  . PRO A 1 143 ? -2.833  -29.860 -15.567 1.000 40.214 ? 169 PRO A CG  1 ? 
ATOM   762  C CD  . PRO A 1 143 ? -2.180  -28.998 -14.510 1.000 43.556 ? 169 PRO A CD  1 ? 
ATOM   763  N N   . GLY A 1 144 ? -3.714  -32.869 -12.184 1.000 40.453 ? 170 GLY A N   1 ? 
ATOM   764  C CA  . GLY A 1 144 ? -3.381  -34.032 -11.364 1.000 40.982 ? 170 GLY A CA  1 ? 
ATOM   765  C C   . GLY A 1 144 ? -4.517  -34.456 -10.472 1.000 43.068 ? 170 GLY A C   1 ? 
ATOM   766  O O   . GLY A 1 144 ? -5.715  -33.962 -10.638 1.000 38.072 ? 170 GLY A O   1 ? 
ATOM   767  N N   . LEU A 1 145 ? -4.164  -35.443 -9.664  1.000 42.392 ? 171 LEU A N   1 ? 
ATOM   768  C CA  . LEU A 1 145 ? -5.006  -36.113 -8.669  1.000 39.669 ? 171 LEU A CA  1 ? 
ATOM   769  C C   . LEU A 1 145 ? -4.626  -35.523 -7.316  1.000 45.387 ? 171 LEU A C   1 ? 
ATOM   770  O O   . LEU A 1 145 ? -3.417  -35.609 -6.902  1.000 36.308 ? 171 LEU A O   1 ? 
ATOM   771  C CB  . LEU A 1 145 ? -4.755  -37.612 -8.731  1.000 39.792 ? 171 LEU A CB  1 ? 
ATOM   772  C CG  . LEU A 1 145 ? -5.500  -38.413 -7.686  1.000 39.043 ? 171 LEU A CG  1 ? 
ATOM   773  C CD1 . LEU A 1 145 ? -7.016  -38.175 -7.832  1.000 46.591 ? 171 LEU A CD1 1 ? 
ATOM   774  C CD2 . LEU A 1 145 ? -5.180  -39.882 -7.822  1.000 36.374 ? 171 LEU A CD2 1 ? 
ATOM   775  N N   . TYR A 1 146 ? -5.596  -34.854 -6.709  1.000 34.435 ? 172 TYR A N   1 ? 
ATOM   776  C CA  . TYR A 1 146 ? -5.503  -34.206 -5.389  1.000 34.798 ? 172 TYR A CA  1 ? 
ATOM   777  C C   . TYR A 1 146 ? -6.383  -34.917 -4.365  1.000 43.145 ? 172 TYR A C   1 ? 
ATOM   778  O O   . TYR A 1 146 ? -7.581  -35.250 -4.673  1.000 41.324 ? 172 TYR A O   1 ? 
ATOM   779  C CB  . TYR A 1 146 ? -5.978  -32.774 -5.481  1.000 32.008 ? 172 TYR A CB  1 ? 
ATOM   780  C CG  . TYR A 1 146 ? -5.207  -31.821 -6.333  1.000 37.135 ? 172 TYR A CG  1 ? 
ATOM   781  C CD1 . TYR A 1 146 ? -5.162  -31.950 -7.709  1.000 37.746 ? 172 TYR A CD1 1 ? 
ATOM   782  C CD2 . TYR A 1 146 ? -4.594  -30.712 -5.749  1.000 39.587 ? 172 TYR A CD2 1 ? 
ATOM   783  C CE1 . TYR A 1 146 ? -4.447  -31.040 -8.478  1.000 44.115 ? 172 TYR A CE1 1 ? 
ATOM   784  C CE2 . TYR A 1 146 ? -3.899  -29.786 -6.509  1.000 38.285 ? 172 TYR A CE2 1 ? 
ATOM   785  C CZ  . TYR A 1 146 ? -3.835  -29.948 -7.880  1.000 38.794 ? 172 TYR A CZ  1 ? 
ATOM   786  O OH  . TYR A 1 146 ? -3.230  -29.001 -8.636  1.000 38.908 ? 172 TYR A OH  1 ? 
ATOM   787  N N   . LYS A 1 147 ? -5.868  -35.079 -3.148  1.000 37.640 ? 173 LYS A N   1 ? 
ATOM   788  C CA  . LYS A 1 147 ? -6.612  -35.755 -2.061  1.000 41.840 ? 173 LYS A CA  1 ? 
ATOM   789  C C   . LYS A 1 147 ? -6.558  -34.896 -0.802  1.000 39.942 ? 173 LYS A C   1 ? 
ATOM   790  O O   . LYS A 1 147 ? -5.543  -34.212 -0.567  1.000 43.116 ? 173 LYS A O   1 ? 
ATOM   791  C CB  . LYS A 1 147 ? -6.098  -37.181 -1.884  1.000 40.606 ? 173 LYS A CB  1 ? 
ATOM   792  C CG  . LYS A 1 147 ? -6.840  -38.013 -0.850  1.000 50.364 ? 173 LYS A CG  1 ? 
ATOM   793  C CD  . LYS A 1 147 ? -6.431  -39.490 -0.963  1.000 62.316 ? 173 LYS A CD  1 ? 
ATOM   794  C CE  . LYS A 1 147 ? -7.032  -40.407 0.077   1.000 63.699 ? 173 LYS A CE  1 ? 
ATOM   795  N NZ  . LYS A 1 147 ? -8.479  -40.141 0.204   1.000 67.662 ? 173 LYS A NZ  1 ? 
ATOM   796  N N   . TRP A 1 148 ? -7.678  -34.854 -0.091  1.000 37.530 ? 174 TRP A N   1 ? 
ATOM   797  C CA  . TRP A 1 148 ? -7.797  -34.271 1.261   1.000 38.581 ? 174 TRP A CA  1 ? 
ATOM   798  C C   . TRP A 1 148 ? -8.486  -35.297 2.145   1.000 42.515 ? 174 TRP A C   1 ? 
ATOM   799  O O   . TRP A 1 148 ? -9.560  -35.805 1.733   1.000 42.062 ? 174 TRP A O   1 ? 
ATOM   800  C CB  . TRP A 1 148 ? -8.529  -32.943 1.262   1.000 38.734 ? 174 TRP A CB  1 ? 
ATOM   801  C CG  . TRP A 1 148 ? -7.841  -31.827 0.552   1.000 39.961 ? 174 TRP A CG  1 ? 
ATOM   802  C CD1 . TRP A 1 148 ? -7.112  -30.821 1.124   1.000 40.580 ? 174 TRP A CD1 1 ? 
ATOM   803  C CD2 . TRP A 1 148 ? -7.902  -31.525 -0.849  1.000 38.818 ? 174 TRP A CD2 1 ? 
ATOM   804  N NE1 . TRP A 1 148 ? -6.687  -29.938 0.168   1.000 38.009 ? 174 TRP A NE1 1 ? 
ATOM   805  C CE2 . TRP A 1 148 ? -7.170  -30.332 -1.044  1.000 40.508 ? 174 TRP A CE2 1 ? 
ATOM   806  C CE3 . TRP A 1 148 ? -8.488  -32.149 -1.955  1.000 37.769 ? 174 TRP A CE3 1 ? 
ATOM   807  C CZ2 . TRP A 1 148 ? -6.985  -29.765 -2.302  1.000 46.032 ? 174 TRP A CZ2 1 ? 
ATOM   808  C CZ3 . TRP A 1 148 ? -8.317  -31.582 -3.195  1.000 39.412 ? 174 TRP A CZ3 1 ? 
ATOM   809  C CH2 . TRP A 1 148 ? -7.569  -30.412 -3.366  1.000 40.537 ? 174 TRP A CH2 1 ? 
ATOM   810  N N   . THR A 1 149 ? -7.889  -35.595 3.304   1.000 44.271 ? 175 THR A N   1 ? 
ATOM   811  C CA  . THR A 1 149 ? -8.411  -36.613 4.257   1.000 46.254 ? 175 THR A CA  1 ? 
ATOM   812  C C   . THR A 1 149 ? -9.335  -35.894 5.240   1.000 43.350 ? 175 THR A C   1 ? 
ATOM   813  O O   . THR A 1 149 ? -9.794  -36.558 6.135   1.000 55.831 ? 175 THR A O   1 ? 
ATOM   814  C CB  . THR A 1 149 ? -7.293  -37.396 4.973   1.000 45.533 ? 175 THR A CB  1 ? 
ATOM   815  O OG1 . THR A 1 149 ? -6.404  -36.431 5.517   1.000 40.993 ? 175 THR A OG1 1 ? 
ATOM   816  C CG2 . THR A 1 149 ? -6.518  -38.306 4.058   1.000 44.049 ? 175 THR A CG2 1 ? 
ATOM   817  N N   . SER A 1 150 ? -9.571  -34.597 5.035   1.000 45.525 ? 176 SER A N   1 ? 
ATOM   818  C CA  . SER A 1 150 ? -10.430 -33.706 5.849   1.000 53.010 ? 176 SER A CA  1 ? 
ATOM   819  C C   . SER A 1 150 ? -11.495 -33.008 4.964   1.000 49.477 ? 176 SER A C   1 ? 
ATOM   820  O O   . SER A 1 150 ? -11.645 -33.343 3.784   1.000 48.923 ? 176 SER A O   1 ? 
ATOM   821  C CB  . SER A 1 150 ? -9.555  -32.667 6.511   1.000 52.784 ? 176 SER A CB  1 ? 
ATOM   822  O OG  . SER A 1 150 ? -9.035  -31.796 5.497   1.000 65.759 ? 176 SER A OG  1 ? 
ATOM   823  N N   . THR A 1 151 ? -12.110 -31.964 5.510   1.000 43.910 ? 177 THR A N   1 ? 
ATOM   824  C CA  . THR A 1 151 ? -12.939 -30.945 4.814   1.000 47.164 ? 177 THR A CA  1 ? 
ATOM   825  C C   . THR A 1 151 ? -12.029 -30.019 4.011   1.000 47.005 ? 177 THR A C   1 ? 
ATOM   826  O O   . THR A 1 151 ? -10.967 -29.665 4.504   1.000 48.567 ? 177 THR A O   1 ? 
ATOM   827  C CB  . THR A 1 151 ? -13.815 -30.212 5.845   1.000 47.126 ? 177 THR A CB  1 ? 
ATOM   828  O OG1 . THR A 1 151 ? -14.881 -31.117 6.124   1.000 40.981 ? 177 THR A OG1 1 ? 
ATOM   829  C CG2 . THR A 1 151 ? -14.343 -28.871 5.391   1.000 42.130 ? 177 THR A CG2 1 ? 
ATOM   830  N N   . LEU A 1 152 ? -12.445 -29.665 2.798   1.000 40.953 ? 178 LEU A N   1 ? 
ATOM   831  C CA  . LEU A 1 152 ? -11.782 -28.642 1.958   1.000 39.543 ? 178 LEU A CA  1 ? 
ATOM   832  C C   . LEU A 1 152 ? -12.568 -27.337 1.984   1.000 38.533 ? 178 LEU A C   1 ? 
ATOM   833  O O   . LEU A 1 152 ? -13.828 -27.317 1.671   1.000 34.578 ? 178 LEU A O   1 ? 
ATOM   834  C CB  . LEU A 1 152 ? -11.651 -29.209 0.533   1.000 39.757 ? 178 LEU A CB  1 ? 
ATOM   835  C CG  . LEU A 1 152 ? -10.962 -28.304 -0.474  1.000 41.571 ? 178 LEU A CG  1 ? 
ATOM   836  C CD1 . LEU A 1 152 ? -9.569  -27.882 0.029   1.000 42.805 ? 178 LEU A CD1 1 ? 
ATOM   837  C CD2 . LEU A 1 152 ? -10.850 -29.025 -1.817  1.000 42.665 ? 178 LEU A CD2 1 ? 
ATOM   838  N N   . ASN A 1 153 ? -11.856 -26.255 2.237   1.000 34.173 ? 179 ASN A N   1 ? 
ATOM   839  C CA  . ASN A 1 153 ? -12.384 -24.870 2.211   1.000 34.350 ? 179 ASN A CA  1 ? 
ATOM   840  C C   . ASN A 1 153 ? -11.720 -24.085 1.110   1.000 41.643 ? 179 ASN A C   1 ? 
ATOM   841  O O   . ASN A 1 153 ? -10.477 -24.227 0.915   1.000 41.001 ? 179 ASN A O   1 ? 
ATOM   842  C CB  . ASN A 1 153 ? -12.238 -24.201 3.571   1.000 41.660 ? 179 ASN A CB  1 ? 
ATOM   843  C CG  . ASN A 1 153 ? -12.912 -25.046 4.626   1.000 47.647 ? 179 ASN A CG  1 ? 
ATOM   844  O OD1 . ASN A 1 153 ? -14.127 -25.184 4.629   1.000 48.307 ? 179 ASN A OD1 1 ? 
ATOM   845  N ND2 . ASN A 1 153 ? -12.137 -25.709 5.461   1.000 49.027 ? 179 ASN A ND2 1 ? 
ATOM   846  N N   . ILE A 1 154 ? -12.515 -23.286 0.414   1.000 34.130 ? 180 ILE A N   1 ? 
ATOM   847  C CA  . ILE A 1 154 ? -12.049 -22.333 -0.616  1.000 38.662 ? 180 ILE A CA  1 ? 
ATOM   848  C C   . ILE A 1 154 ? -12.511 -20.931 -0.235  1.000 43.856 ? 180 ILE A C   1 ? 
ATOM   849  O O   . ILE A 1 154 ? -13.531 -20.452 -0.728  1.000 49.736 ? 180 ILE A O   1 ? 
ATOM   850  C CB  . ILE A 1 154 ? -12.509 -22.756 -2.015  1.000 36.871 ? 180 ILE A CB  1 ? 
ATOM   851  C CG1 . ILE A 1 154 ? -12.394 -24.262 -2.232  1.000 38.397 ? 180 ILE A CG1 1 ? 
ATOM   852  C CG2 . ILE A 1 154 ? -11.781 -21.922 -3.042  1.000 37.212 ? 180 ILE A CG2 1 ? 
ATOM   853  C CD1 . ILE A 1 154 ? -12.869 -24.730 -3.605  1.000 40.788 ? 180 ILE A CD1 1 ? 
ATOM   854  N N   . PRO A 1 155 ? -11.779 -20.232 0.663   1.000 48.739 ? 181 PRO A N   1 ? 
ATOM   855  C CA  . PRO A 1 155 ? -12.197 -18.925 1.169   1.000 44.462 ? 181 PRO A CA  1 ? 
ATOM   856  C C   . PRO A 1 155 ? -11.920 -17.735 0.256   1.000 47.165 ? 181 PRO A C   1 ? 
ATOM   857  O O   . PRO A 1 155 ? -12.496 -16.683 0.480   1.000 47.945 ? 181 PRO A O   1 ? 
ATOM   858  C CB  . PRO A 1 155 ? -11.373 -18.761 2.458   1.000 51.021 ? 181 PRO A CB  1 ? 
ATOM   859  C CG  . PRO A 1 155 ? -10.846 -20.153 2.743   1.000 50.634 ? 181 PRO A CG  1 ? 
ATOM   860  C CD  . PRO A 1 155 ? -10.591 -20.732 1.368   1.000 52.661 ? 181 PRO A CD  1 ? 
ATOM   861  N N   . THR A 1 156 ? -11.039 -17.885 -0.727  1.000 46.104 ? 182 THR A N   1 ? 
ATOM   862  C CA  . THR A 1 156 ? -10.757 -16.790 -1.687  1.000 46.102 ? 182 THR A CA  1 ? 
ATOM   863  C C   . THR A 1 156 ? -10.531 -17.388 -3.064  1.000 43.971 ? 182 THR A C   1 ? 
ATOM   864  O O   . THR A 1 156 ? -10.364 -18.643 -3.152  1.000 46.180 ? 182 THR A O   1 ? 
ATOM   865  C CB  . THR A 1 156 ? -9.532  -15.958 -1.261  1.000 55.363 ? 182 THR A CB  1 ? 
ATOM   866  O OG1 . THR A 1 156 ? -8.364  -16.795 -1.258  1.000 51.543 ? 182 THR A OG1 1 ? 
ATOM   867  C CG2 . THR A 1 156 ? -9.725  -15.316 0.096   1.000 52.323 ? 182 THR A CG2 1 ? 
ATOM   868  N N   . ASP A 1 157 ? -10.473 -16.508 -4.061  1.000 43.245 ? 183 ASP A N   1 ? 
ATOM   869  C CA  . ASP A 1 157 ? -10.344 -16.860 -5.493  1.000 45.985 ? 183 ASP A CA  1 ? 
ATOM   870  C C   . ASP A 1 157 ? -9.218  -17.876 -5.669  1.000 51.978 ? 183 ASP A C   1 ? 
ATOM   871  O O   . ASP A 1 157 ? -8.219  -17.801 -4.947  1.000 52.014 ? 183 ASP A O   1 ? 
ATOM   872  C CB  . ASP A 1 157 ? -10.147 -15.642 -6.388  1.000 46.174 ? 183 ASP A CB  1 ? 
ATOM   873  C CG  . ASP A 1 157 ? -11.335 -14.689 -6.446  1.000 51.489 ? 183 ASP A CG  1 ? 
ATOM   874  O OD1 . ASP A 1 157 ? -12.386 -14.984 -5.833  1.000 55.685 ? 183 ASP A OD1 1 ? 
ATOM   875  O OD2 . ASP A 1 157 ? -11.203 -13.670 -7.119  1.000 54.590 ? 183 ASP A OD2 1 ? 
ATOM   876  N N   . ILE A 1 158 ? -9.442  -18.826 -6.571  1.000 46.814 ? 184 ILE A N   1 ? 
ATOM   877  C CA  . ILE A 1 158 ? -8.434  -19.798 -7.052  1.000 42.621 ? 184 ILE A CA  1 ? 
ATOM   878  C C   . ILE A 1 158 ? -8.448  -19.785 -8.568  1.000 45.610 ? 184 ILE A C   1 ? 
ATOM   879  O O   . ILE A 1 158 ? -9.482  -19.415 -9.201  1.000 41.993 ? 184 ILE A O   1 ? 
ATOM   880  C CB  . ILE A 1 158 ? -8.676  -21.199 -6.472  1.000 41.732 ? 184 ILE A CB  1 ? 
ATOM   881  C CG1 . ILE A 1 158 ? -10.039 -21.792 -6.855  1.000 42.676 ? 184 ILE A CG1 1 ? 
ATOM   882  C CG2 . ILE A 1 158 ? -8.507  -21.140 -4.978  1.000 42.841 ? 184 ILE A CG2 1 ? 
ATOM   883  C CD1 . ILE A 1 158 ? -10.180 -23.232 -6.485  1.000 42.249 ? 184 ILE A CD1 1 ? 
ATOM   884  N N   . THR A 1 159 ? -7.327  -20.191 -9.142  1.000 45.053 ? 185 THR A N   1 ? 
ATOM   885  C CA  . THR A 1 159 ? -7.238  -20.461 -10.579 1.000 41.143 ? 185 THR A CA  1 ? 
ATOM   886  C C   . THR A 1 159 ? -6.987  -21.950 -10.751 1.000 37.587 ? 185 THR A C   1 ? 
ATOM   887  O O   . THR A 1 159 ? -6.272  -22.550 -9.938  1.000 41.176 ? 185 THR A O   1 ? 
ATOM   888  C CB  . THR A 1 159 ? -6.227  -19.534 -11.254 1.000 45.125 ? 185 THR A CB  1 ? 
ATOM   889  O OG1 . THR A 1 159 ? -6.661  -18.198 -10.990 1.000 48.048 ? 185 THR A OG1 1 ? 
ATOM   890  C CG2 . THR A 1 159 ? -6.116  -19.788 -12.743 1.000 45.364 ? 185 THR A CG2 1 ? 
ATOM   891  N N   . ILE A 1 160 ? -7.566  -22.507 -11.805 1.000 39.531 ? 186 ILE A N   1 ? 
ATOM   892  C CA  . ILE A 1 160 ? -7.246  -23.868 -12.300 1.000 41.085 ? 186 ILE A CA  1 ? 
ATOM   893  C C   . ILE A 1 160 ? -6.638  -23.642 -13.681 1.000 45.981 ? 186 ILE A C   1 ? 
ATOM   894  O O   . ILE A 1 160 ? -7.321  -22.996 -14.492 1.000 43.965 ? 186 ILE A O   1 ? 
ATOM   895  C CB  . ILE A 1 160 ? -8.506  -24.748 -12.295 1.000 42.584 ? 186 ILE A CB  1 ? 
ATOM   896  C CG1 . ILE A 1 160 ? -9.020  -24.935 -10.856 1.000 40.551 ? 186 ILE A CG1 1 ? 
ATOM   897  C CG2 . ILE A 1 160 ? -8.240  -26.065 -13.010 1.000 40.327 ? 186 ILE A CG2 1 ? 
ATOM   898  C CD1 . ILE A 1 160 ? -10.335 -25.661 -10.769 1.000 43.628 ? 186 ILE A CD1 1 ? 
ATOM   899  N N   . SER A 1 161 ? -5.373  -24.059 -13.861 1.000 49.955 ? 187 SER A N   1 ? 
ATOM   900  C CA  . SER A 1 161 ? -4.467  -23.710 -14.991 1.000 49.591 ? 187 SER A CA  1 ? 
ATOM   901  C C   . SER A 1 161 ? -3.914  -24.985 -15.626 1.000 42.946 ? 187 SER A C   1 ? 
ATOM   902  O O   . SER A 1 161 ? -3.322  -25.777 -14.882 1.000 43.425 ? 187 SER A O   1 ? 
ATOM   903  C CB  . SER A 1 161 ? -3.341  -22.859 -14.485 1.000 56.995 ? 187 SER A CB  1 ? 
ATOM   904  O OG  . SER A 1 161 ? -3.052  -21.826 -15.399 1.000 61.175 ? 187 SER A OG  1 ? 
ATOM   905  N N   . GLY A 1 162 ? -4.065  -25.148 -16.945 1.000 41.806 ? 188 GLY A N   1 ? 
ATOM   906  C CA  . GLY A 1 162 ? -3.743  -26.392 -17.682 1.000 44.554 ? 188 GLY A CA  1 ? 
ATOM   907  C C   . GLY A 1 162 ? -4.181  -26.329 -19.140 1.000 46.037 ? 188 GLY A C   1 ? 
ATOM   908  O O   . GLY A 1 162 ? -4.783  -25.313 -19.535 1.000 49.133 ? 188 GLY A O   1 ? 
ATOM   909  N N   . SER A 1 163 ? -3.924  -27.382 -19.925 1.000 47.932 ? 189 SER A N   1 ? 
ATOM   910  C CA  . SER A 1 163 ? -4.341  -27.442 -21.356 1.000 50.916 ? 189 SER A CA  1 ? 
ATOM   911  C C   . SER A 1 163 ? -5.834  -27.810 -21.484 1.000 51.193 ? 189 SER A C   1 ? 
ATOM   912  O O   . SER A 1 163 ? -6.448  -28.243 -20.505 1.000 39.695 ? 189 SER A O   1 ? 
ATOM   913  C CB  . SER A 1 163 ? -3.488  -28.382 -22.143 1.000 47.112 ? 189 SER A CB  1 ? 
ATOM   914  O OG  . SER A 1 163 ? -3.938  -29.723 -22.022 1.000 54.194 ? 189 SER A OG  1 ? 
ATOM   915  N N   . SER A 1 164 ? -6.368  -27.704 -22.692 1.000 45.980 ? 190 SER A N   1 ? 
ATOM   916  C CA  . SER A 1 164 ? -7.753  -28.080 -23.060 1.000 49.997 ? 190 SER A CA  1 ? 
ATOM   917  C C   . SER A 1 164 ? -7.941  -29.588 -22.879 1.000 48.828 ? 190 SER A C   1 ? 
ATOM   918  O O   . SER A 1 164 ? -9.092  -30.029 -22.819 1.000 48.516 ? 190 SER A O   1 ? 
ATOM   919  C CB  . SER A 1 164 ? -8.041  -27.654 -24.467 1.000 52.735 ? 190 SER A CB  1 ? 
ATOM   920  O OG  . SER A 1 164 ? -7.050  -28.188 -25.329 1.000 51.224 ? 190 SER A OG  1 ? 
ATOM   921  N N   . THR A 1 165 ? -6.867  -30.357 -22.745 1.000 39.850 ? 191 THR A N   1 ? 
ATOM   922  C CA  . THR A 1 165 ? -6.977  -31.829 -22.589 1.000 44.936 ? 191 THR A CA  1 ? 
ATOM   923  C C   . THR A 1 165 ? -6.537  -32.289 -21.187 1.000 38.788 ? 191 THR A C   1 ? 
ATOM   924  O O   . THR A 1 165 ? -6.629  -33.504 -20.918 1.000 46.547 ? 191 THR A O   1 ? 
ATOM   925  C CB  . THR A 1 165 ? -6.215  -32.521 -23.725 1.000 54.187 ? 191 THR A CB  1 ? 
ATOM   926  O OG1 . THR A 1 165 ? -4.817  -32.255 -23.541 1.000 52.966 ? 191 THR A OG1 1 ? 
ATOM   927  C CG2 . THR A 1 165 ? -6.709  -32.042 -25.078 1.000 54.482 ? 191 THR A CG2 1 ? 
ATOM   928  N N   . ASP A 1 166 ? -6.071  -31.384 -20.331 1.000 40.060 ? 192 ASP A N   1 ? 
ATOM   929  C CA  . ASP A 1 166 ? -5.593  -31.720 -18.955 1.000 40.722 ? 192 ASP A CA  1 ? 
ATOM   930  C C   . ASP A 1 166 ? -6.830  -32.051 -18.082 1.000 45.628 ? 192 ASP A C   1 ? 
ATOM   931  O O   . ASP A 1 166 ? -7.962  -31.613 -18.418 1.000 41.723 ? 192 ASP A O   1 ? 
ATOM   932  C CB  . ASP A 1 166 ? -4.757  -30.566 -18.376 1.000 42.522 ? 192 ASP A CB  1 ? 
ATOM   933  C CG  . ASP A 1 166 ? -3.309  -30.486 -18.876 1.000 44.963 ? 192 ASP A CG  1 ? 
ATOM   934  O OD1 . ASP A 1 166 ? -2.740  -31.524 -19.089 1.000 40.463 ? 192 ASP A OD1 1 ? 
ATOM   935  O OD2 . ASP A 1 166 ? -2.793  -29.383 -19.047 1.000 48.980 ? 192 ASP A OD2 1 ? 
ATOM   936  N N   . VAL A 1 167 ? -6.620  -32.840 -17.032 1.000 40.804 ? 193 VAL A N   1 ? 
ATOM   937  C CA  . VAL A 1 167 ? -7.686  -33.402 -16.163 1.000 43.433 ? 193 VAL A CA  1 ? 
ATOM   938  C C   . VAL A 1 167 ? -7.338  -33.068 -14.712 1.000 43.450 ? 193 VAL A C   1 ? 
ATOM   939  O O   . VAL A 1 167 ? -6.154  -33.170 -14.321 1.000 34.552 ? 193 VAL A O   1 ? 
ATOM   940  C CB  . VAL A 1 167 ? -7.828  -34.923 -16.373 1.000 45.234 ? 193 VAL A CB  1 ? 
ATOM   941  C CG1 . VAL A 1 167 ? -8.737  -35.547 -15.318 1.000 42.724 ? 193 VAL A CG1 1 ? 
ATOM   942  C CG2 . VAL A 1 167 ? -8.321  -35.268 -17.772 1.000 43.803 ? 193 VAL A CG2 1 ? 
ATOM   943  N N   . TRP A 1 168 ? -8.335  -32.704 -13.919 1.000 36.230 ? 194 TRP A N   1 ? 
ATOM   944  C CA  . TRP A 1 168 ? -8.191  -32.511 -12.457 1.000 32.444 ? 194 TRP A CA  1 ? 
ATOM   945  C C   . TRP A 1 168 ? -9.231  -33.377 -11.765 1.000 40.817 ? 194 TRP A C   1 ? 
ATOM   946  O O   . TRP A 1 168 ? -10.439 -33.274 -12.160 1.000 36.862 ? 194 TRP A O   1 ? 
ATOM   947  C CB  . TRP A 1 168 ? -8.366  -31.045 -12.083 1.000 35.572 ? 194 TRP A CB  1 ? 
ATOM   948  C CG  . TRP A 1 168 ? -7.411  -30.059 -12.660 1.000 42.043 ? 194 TRP A CG  1 ? 
ATOM   949  C CD1 . TRP A 1 168 ? -6.409  -29.416 -11.984 1.000 45.529 ? 194 TRP A CD1 1 ? 
ATOM   950  C CD2 . TRP A 1 168 ? -7.402  -29.526 -13.995 1.000 43.528 ? 194 TRP A CD2 1 ? 
ATOM   951  N NE1 . TRP A 1 168 ? -5.770  -28.530 -12.804 1.000 47.337 ? 194 TRP A NE1 1 ? 
ATOM   952  C CE2 . TRP A 1 168 ? -6.339  -28.591 -14.051 1.000 46.203 ? 194 TRP A CE2 1 ? 
ATOM   953  C CE3 . TRP A 1 168 ? -8.103  -29.813 -15.168 1.000 41.432 ? 194 TRP A CE3 1 ? 
ATOM   954  C CZ2 . TRP A 1 168 ? -6.013  -27.896 -15.216 1.000 42.883 ? 194 TRP A CZ2 1 ? 
ATOM   955  C CZ3 . TRP A 1 168 ? -7.791  -29.109 -16.311 1.000 45.839 ? 194 TRP A CZ3 1 ? 
ATOM   956  C CH2 . TRP A 1 168 ? -6.759  -28.164 -16.335 1.000 42.577 ? 194 TRP A CH2 1 ? 
ATOM   957  N N   . ILE A 1 169 ? -8.784  -34.239 -10.859 1.000 32.743 ? 195 ILE A N   1 ? 
ATOM   958  C CA  . ILE A 1 169 ? -9.655  -34.983 -9.918  1.000 32.709 ? 195 ILE A CA  1 ? 
ATOM   959  C C   . ILE A 1 169 ? -9.285  -34.527 -8.504  1.000 40.604 ? 195 ILE A C   1 ? 
ATOM   960  O O   . ILE A 1 169 ? -8.075  -34.606 -8.087  1.000 36.838 ? 195 ILE A O   1 ? 
ATOM   961  C CB  . ILE A 1 169 ? -9.518  -36.497 -10.157 1.000 31.384 ? 195 ILE A CB  1 ? 
ATOM   962  C CG1 . ILE A 1 169 ? -9.797  -36.845 -11.617 1.000 33.867 ? 195 ILE A CG1 1 ? 
ATOM   963  C CG2 . ILE A 1 169 ? -10.346 -37.285 -9.166  1.000 34.460 ? 195 ILE A CG2 1 ? 
ATOM   964  C CD1 . ILE A 1 169 ? -9.679  -38.303 -11.975 1.000 34.321 ? 195 ILE A CD1 1 ? 
ATOM   965  N N   . PHE A 1 170 ? -10.259 -33.947 -7.819  1.000 37.099 ? 196 PHE A N   1 ? 
ATOM   966  C CA  . PHE A 1 170 ? -10.172 -33.512 -6.405  1.000 37.537 ? 196 PHE A CA  1 ? 
ATOM   967  C C   . PHE A 1 170 ? -10.923 -34.497 -5.508  1.000 42.176 ? 196 PHE A C   1 ? 
ATOM   968  O O   . PHE A 1 170 ? -12.193 -34.606 -5.619  1.000 39.902 ? 196 PHE A O   1 ? 
ATOM   969  C CB  . PHE A 1 170 ? -10.726 -32.097 -6.304  1.000 34.761 ? 196 PHE A CB  1 ? 
ATOM   970  C CG  . PHE A 1 170 ? -10.031 -31.094 -7.182  1.000 39.569 ? 196 PHE A CG  1 ? 
ATOM   971  C CD1 . PHE A 1 170 ? -8.723  -30.712 -6.912  1.000 39.273 ? 196 PHE A CD1 1 ? 
ATOM   972  C CD2 . PHE A 1 170 ? -10.666 -30.513 -8.267  1.000 39.412 ? 196 PHE A CD2 1 ? 
ATOM   973  C CE1 . PHE A 1 170 ? -8.098  -29.749 -7.683  1.000 38.004 ? 196 PHE A CE1 1 ? 
ATOM   974  C CE2 . PHE A 1 170 ? -10.013 -29.591 -9.063  1.000 40.451 ? 196 PHE A CE2 1 ? 
ATOM   975  C CZ  . PHE A 1 170 ? -8.728  -29.204 -8.769  1.000 39.137 ? 196 PHE A CZ  1 ? 
ATOM   976  N N   . GLN A 1 171 ? -10.203 -35.269 -4.695  1.000 35.413 ? 197 GLN A N   1 ? 
ATOM   977  C CA  . GLN A 1 171 ? -10.790 -36.277 -3.776  1.000 36.209 ? 197 GLN A CA  1 ? 
ATOM   978  C C   . GLN A 1 171 ? -10.882 -35.649 -2.392  1.000 42.132 ? 197 GLN A C   1 ? 
ATOM   979  O O   . GLN A 1 171 ? -9.824  -35.195 -1.875  1.000 39.735 ? 197 GLN A O   1 ? 
ATOM   980  C CB  . GLN A 1 171 ? -9.963  -37.552 -3.701  1.000 36.213 ? 197 GLN A CB  1 ? 
ATOM   981  C CG  . GLN A 1 171 ? -9.800  -38.286 -5.019  1.000 41.725 ? 197 GLN A CG  1 ? 
ATOM   982  C CD  . GLN A 1 171 ? -8.807  -39.420 -4.943  1.000 44.525 ? 197 GLN A CD  1 ? 
ATOM   983  O OE1 . GLN A 1 171 ? -7.769  -39.294 -4.292  1.000 48.143 ? 197 GLN A OE1 1 ? 
ATOM   984  N NE2 . GLN A 1 171 ? -9.085  -40.518 -5.634  1.000 38.644 ? 197 GLN A NE2 1 ? 
ATOM   985  N N   . VAL A 1 172 ? -12.094 -35.531 -1.841  1.000 35.063 ? 198 VAL A N   1 ? 
ATOM   986  C CA  . VAL A 1 172 ? -12.316 -34.821 -0.554  1.000 38.145 ? 198 VAL A CA  1 ? 
ATOM   987  C C   . VAL A 1 172 ? -13.056 -35.776 0.375   1.000 43.918 ? 198 VAL A C   1 ? 
ATOM   988  O O   . VAL A 1 172 ? -14.250 -36.060 0.082   1.000 41.323 ? 198 VAL A O   1 ? 
ATOM   989  C CB  . VAL A 1 172 ? -13.077 -33.491 -0.701  1.000 38.211 ? 198 VAL A CB  1 ? 
ATOM   990  C CG1 . VAL A 1 172 ? -13.219 -32.784 0.645   1.000 40.931 ? 198 VAL A CG1 1 ? 
ATOM   991  C CG2 . VAL A 1 172 ? -12.489 -32.584 -1.736  1.000 36.702 ? 198 VAL A CG2 1 ? 
ATOM   992  N N   . ALA A 1 173 ? -12.405 -36.235 1.456   1.000 42.960 ? 199 ALA A N   1 ? 
ATOM   993  C CA  . ALA A 1 173 ? -12.985 -37.219 2.412   1.000 45.275 ? 199 ALA A CA  1 ? 
ATOM   994  C C   . ALA A 1 173 ? -14.006 -36.576 3.384   1.000 47.292 ? 199 ALA A C   1 ? 
ATOM   995  O O   . ALA A 1 173 ? -14.671 -37.353 4.076   1.000 63.605 ? 199 ALA A O   1 ? 
ATOM   996  C CB  . ALA A 1 173 ? -11.916 -37.979 3.166   1.000 42.153 ? 199 ALA A CB  1 ? 
ATOM   997  N N   . GLY A 1 174 ? -14.175 -35.252 3.423   1.000 40.323 ? 200 GLY A N   1 ? 
ATOM   998  C CA  . GLY A 1 174 ? -15.195 -34.564 4.224   1.000 41.960 ? 200 GLY A CA  1 ? 
ATOM   999  C C   . GLY A 1 174 ? -16.109 -33.705 3.364   1.000 42.972 ? 200 GLY A C   1 ? 
ATOM   1000 O O   . GLY A 1 174 ? -16.435 -34.112 2.247   1.000 40.456 ? 200 GLY A O   1 ? 
ATOM   1001 N N   . ASN A 1 175 ? -16.451 -32.520 3.854   1.000 37.205 ? 201 ASN A N   1 ? 
ATOM   1002 C CA  . ASN A 1 175 ? -17.228 -31.494 3.126   1.000 42.504 ? 201 ASN A CA  1 ? 
ATOM   1003 C C   . ASN A 1 175 ? -16.342 -30.701 2.176   1.000 42.769 ? 201 ASN A C   1 ? 
ATOM   1004 O O   . ASN A 1 175 ? -15.106 -30.666 2.344   1.000 40.927 ? 201 ASN A O   1 ? 
ATOM   1005 C CB  . ASN A 1 175 ? -17.856 -30.472 4.079   1.000 43.784 ? 201 ASN A CB  1 ? 
ATOM   1006 C CG  . ASN A 1 175 ? -18.735 -31.127 5.112   1.000 50.260 ? 201 ASN A CG  1 ? 
ATOM   1007 O OD1 . ASN A 1 175 ? -19.288 -32.203 4.859   1.000 44.011 ? 201 ASN A OD1 1 ? 
ATOM   1008 N ND2 . ASN A 1 175 ? -18.783 -30.514 6.284   1.000 54.492 ? 201 ASN A ND2 1 ? 
ATOM   1009 N N   . LEU A 1 176 ? -16.993 -29.965 1.295   1.000 35.014 ? 202 LEU A N   1 ? 
ATOM   1010 C CA  . LEU A 1 176 ? -16.377 -28.935 0.458   1.000 32.992 ? 202 LEU A CA  1 ? 
ATOM   1011 C C   . LEU A 1 176 ? -17.143 -27.639 0.644   1.000 39.521 ? 202 LEU A C   1 ? 
ATOM   1012 O O   . LEU A 1 176 ? -18.367 -27.602 0.359   1.000 44.078 ? 202 LEU A O   1 ? 
ATOM   1013 C CB  . LEU A 1 176 ? -16.403 -29.443 -0.986  1.000 33.610 ? 202 LEU A CB  1 ? 
ATOM   1014 C CG  . LEU A 1 176 ? -15.992 -28.475 -2.089  1.000 34.191 ? 202 LEU A CG  1 ? 
ATOM   1015 C CD1 . LEU A 1 176 ? -14.542 -27.981 -1.890  1.000 37.958 ? 202 LEU A CD1 1 ? 
ATOM   1016 C CD2 . LEU A 1 176 ? -16.157 -29.176 -3.448  1.000 34.306 ? 202 LEU A CD2 1 ? 
ATOM   1017 N N   . ASN A 1 177 ? -16.446 -26.597 1.035   1.000 34.675 ? 203 ASN A N   1 ? 
ATOM   1018 C CA  . ASN A 1 177 ? -17.033 -25.264 1.290   1.000 38.855 ? 203 ASN A CA  1 ? 
ATOM   1019 C C   . ASN A 1 177 ? -16.370 -24.293 0.348   1.000 42.541 ? 203 ASN A C   1 ? 
ATOM   1020 O O   . ASN A 1 177 ? -15.130 -24.386 0.140   1.000 40.295 ? 203 ASN A O   1 ? 
ATOM   1021 C CB  . ASN A 1 177 ? -16.948 -24.885 2.781   1.000 42.939 ? 203 ASN A CB  1 ? 
ATOM   1022 C CG  . ASN A 1 177 ? -17.561 -25.979 3.633   1.000 50.859 ? 203 ASN A CG  1 ? 
ATOM   1023 O OD1 . ASN A 1 177 ? -18.744 -26.303 3.471   1.000 47.369 ? 203 ASN A OD1 1 ? 
ATOM   1024 N ND2 . ASN A 1 177 ? -16.756 -26.636 4.457   1.000 45.718 ? 203 ASN A ND2 1 ? 
ATOM   1025 N N   . MET A 1 178 ? -17.153 -23.378 -0.189  1.000 37.155 ? 204 MET A N   1 ? 
ATOM   1026 C CA  . MET A 1 178 ? -16.597 -22.223 -0.891  1.000 40.552 ? 204 MET A CA  1 ? 
ATOM   1027 C C   . MET A 1 178 ? -17.378 -21.026 -0.391  1.000 46.265 ? 204 MET A C   1 ? 
ATOM   1028 O O   . MET A 1 178 ? -18.596 -21.110 -0.344  1.000 47.976 ? 204 MET A O   1 ? 
ATOM   1029 C CB  . MET A 1 178 ? -16.731 -22.421 -2.403  1.000 41.660 ? 204 MET A CB  1 ? 
ATOM   1030 C CG  . MET A 1 178 ? -16.015 -21.372 -3.184  1.000 42.228 ? 204 MET A CG  1 ? 
ATOM   1031 S SD  . MET A 1 178 ? -15.615 -21.890 -4.894  1.000 46.633 ? 204 MET A SD  1 ? 
ATOM   1032 C CE  . MET A 1 178 ? -17.123 -21.362 -5.718  1.000 47.084 ? 204 MET A CE  1 ? 
ATOM   1033 N N   . SER A 1 179 ? -16.690 -19.984 0.029   1.000 42.328 ? 205 SER A N   1 ? 
ATOM   1034 C CA  . SER A 1 179 ? -17.271 -18.785 0.671   1.000 47.117 ? 205 SER A CA  1 ? 
ATOM   1035 C C   . SER A 1 179 ? -17.914 -17.876 -0.372  1.000 52.489 ? 205 SER A C   1 ? 
ATOM   1036 O O   . SER A 1 179 ? -17.586 -17.986 -1.573  1.000 48.851 ? 205 SER A O   1 ? 
ATOM   1037 C CB  . SER A 1 179 ? -16.224 -18.007 1.442   1.000 50.714 ? 205 SER A CB  1 ? 
ATOM   1038 O OG  . SER A 1 179 ? -15.545 -18.858 2.343   1.000 56.151 ? 205 SER A OG  1 ? 
ATOM   1039 N N   . SER A 1 180 ? -18.750 -16.958 0.106   1.000 51.067 ? 206 SER A N   1 ? 
ATOM   1040 C CA  . SER A 1 180 ? -19.470 -15.962 -0.723  1.000 53.145 ? 206 SER A CA  1 ? 
ATOM   1041 C C   . SER A 1 180 ? -18.482 -15.289 -1.653  1.000 49.074 ? 206 SER A C   1 ? 
ATOM   1042 O O   . SER A 1 180 ? -17.344 -15.059 -1.223  1.000 54.594 ? 206 SER A O   1 ? 
ATOM   1043 C CB  . SER A 1 180 ? -20.172 -14.942 0.137   1.000 53.546 ? 206 SER A CB  1 ? 
ATOM   1044 O OG  . SER A 1 180 ? -20.722 -15.573 1.277   1.000 61.033 ? 206 SER A OG  1 ? 
ATOM   1045 N N   . ALA A 1 181 ? -18.892 -15.050 -2.895  1.000 44.890 ? 207 ALA A N   1 ? 
ATOM   1046 C CA  . ALA A 1 181 ? -18.200 -14.180 -3.875  1.000 47.786 ? 207 ALA A CA  1 ? 
ATOM   1047 C C   . ALA A 1 181 ? -16.897 -14.801 -4.371  1.000 41.751 ? 207 ALA A C   1 ? 
ATOM   1048 O O   . ALA A 1 181 ? -16.305 -14.213 -5.283  1.000 51.260 ? 207 ALA A O   1 ? 
ATOM   1049 C CB  . ALA A 1 181 ? -17.934 -12.821 -3.273  1.000 51.536 ? 207 ALA A CB  1 ? 
ATOM   1050 N N   . VAL A 1 182 ? -16.509 -15.973 -3.877  1.000 45.782 ? 208 VAL A N   1 ? 
ATOM   1051 C CA  . VAL A 1 182 ? -15.292 -16.658 -4.400  1.000 46.046 ? 208 VAL A CA  1 ? 
ATOM   1052 C C   . VAL A 1 182 ? -15.564 -17.160 -5.813  1.000 47.831 ? 208 VAL A C   1 ? 
ATOM   1053 O O   . VAL A 1 182 ? -16.581 -17.848 -6.014  1.000 45.805 ? 208 VAL A O   1 ? 
ATOM   1054 C CB  . VAL A 1 182 ? -14.841 -17.806 -3.502  1.000 43.947 ? 208 VAL A CB  1 ? 
ATOM   1055 C CG1 . VAL A 1 182 ? -13.591 -18.450 -4.082  1.000 47.815 ? 208 VAL A CG1 1 ? 
ATOM   1056 C CG2 . VAL A 1 182 ? -14.618 -17.319 -2.075  1.000 48.677 ? 208 VAL A CG2 1 ? 
ATOM   1057 N N   . ARG A 1 183 ? -14.678 -16.828 -6.743  1.000 43.009 ? 209 ARG A N   1 ? 
ATOM   1058 C CA  . ARG A 1 183 ? -14.717 -17.267 -8.164  1.000 47.494 ? 209 ARG A CA  1 ? 
ATOM   1059 C C   . ARG A 1 183 ? -13.590 -18.267 -8.428  1.000 46.963 ? 209 ARG A C   1 ? 
ATOM   1060 O O   . ARG A 1 183 ? -12.435 -17.967 -8.078  1.000 41.570 ? 209 ARG A O   1 ? 
ATOM   1061 C CB  . ARG A 1 183 ? -14.542 -16.074 -9.114  1.000 51.026 ? 209 ARG A CB  1 ? 
ATOM   1062 C CG  . ARG A 1 183 ? -15.597 -14.980 -8.983  1.000 60.356 ? 209 ARG A CG  1 ? 
ATOM   1063 C CD  . ARG A 1 183 ? -15.579 -14.025 -10.178 1.000 65.852 ? 209 ARG A CD  1 ? 
ATOM   1064 N NE  . ARG A 1 183 ? -15.750 -14.731 -11.446 1.000 68.945 ? 209 ARG A NE  1 ? 
ATOM   1065 C CZ  . ARG A 1 183 ? -16.920 -15.150 -11.931 1.000 71.297 ? 209 ARG A CZ  1 ? 
ATOM   1066 N NH1 . ARG A 1 183 ? -18.047 -14.936 -11.267 1.000 71.833 ? 209 ARG A NH1 1 ? 
ATOM   1067 N NH2 . ARG A 1 183 ? -16.953 -15.800 -13.080 1.000 73.266 ? 209 ARG A NH2 1 ? 
ATOM   1068 N N   . ILE A 1 184 ? -13.916 -19.422 -8.999  1.000 44.920 ? 210 ILE A N   1 ? 
ATOM   1069 C CA  . ILE A 1 184 ? -12.920 -20.306 -9.657  1.000 40.951 ? 210 ILE A CA  1 ? 
ATOM   1070 C C   . ILE A 1 184 ? -12.780 -19.833 -11.096 1.000 44.302 ? 210 ILE A C   1 ? 
ATOM   1071 O O   . ILE A 1 184 ? -13.758 -19.860 -11.857 1.000 42.569 ? 210 ILE A O   1 ? 
ATOM   1072 C CB  . ILE A 1 184 ? -13.302 -21.792 -9.546  1.000 41.831 ? 210 ILE A CB  1 ? 
ATOM   1073 C CG1 . ILE A 1 184 ? -13.582 -22.191 -8.096  1.000 38.421 ? 210 ILE A CG1 1 ? 
ATOM   1074 C CG2 . ILE A 1 184 ? -12.239 -22.666 -10.204 1.000 40.440 ? 210 ILE A CG2 1 ? 
ATOM   1075 C CD1 . ILE A 1 184 ? -13.889 -23.679 -7.913  1.000 40.778 ? 210 ILE A CD1 1 ? 
ATOM   1076 N N   . THR A 1 185 ? -11.567 -19.413 -11.440 1.000 42.894 ? 211 THR A N   1 ? 
ATOM   1077 C CA  . THR A 1 185 ? -11.129 -19.012 -12.788 1.000 45.285 ? 211 THR A CA  1 ? 
ATOM   1078 C C   . THR A 1 185 ? -10.425 -20.176 -13.484 1.000 44.880 ? 211 THR A C   1 ? 
ATOM   1079 O O   . THR A 1 185 ? -9.628  -20.856 -12.820 1.000 43.921 ? 211 THR A O   1 ? 
ATOM   1080 C CB  . THR A 1 185 ? -10.200 -17.816 -12.633 1.000 50.671 ? 211 THR A CB  1 ? 
ATOM   1081 O OG1 . THR A 1 185 ? -11.072 -16.880 -11.998 1.000 56.347 ? 211 THR A OG1 1 ? 
ATOM   1082 C CG2 . THR A 1 185 ? -9.620  -17.335 -13.943 1.000 55.955 ? 211 THR A CG2 1 ? 
ATOM   1083 N N   . LEU A 1 186 ? -10.717 -20.403 -14.767 1.000 43.002 ? 212 LEU A N   1 ? 
ATOM   1084 C CA  . LEU A 1 186 ? -9.977  -21.374 -15.605 1.000 46.782 ? 212 LEU A CA  1 ? 
ATOM   1085 C C   . LEU A 1 186 ? -8.940  -20.580 -16.412 1.000 49.608 ? 212 LEU A C   1 ? 
ATOM   1086 O O   . LEU A 1 186 ? -9.276  -19.464 -16.825 1.000 49.337 ? 212 LEU A O   1 ? 
ATOM   1087 C CB  . LEU A 1 186 ? -10.949 -22.125 -16.516 1.000 46.525 ? 212 LEU A CB  1 ? 
ATOM   1088 C CG  . LEU A 1 186 ? -12.023 -22.949 -15.799 1.000 50.164 ? 212 LEU A CG  1 ? 
ATOM   1089 C CD1 . LEU A 1 186 ? -12.768 -23.829 -16.790 1.000 51.744 ? 212 LEU A CD1 1 ? 
ATOM   1090 C CD2 . LEU A 1 186 ? -11.436 -23.813 -14.691 1.000 50.745 ? 212 LEU A CD2 1 ? 
ATOM   1091 N N   . ALA A 1 187 ? -7.712  -21.091 -16.522 1.000 51.069 ? 213 ALA A N   1 ? 
ATOM   1092 C CA  . ALA A 1 187 ? -6.595  -20.468 -17.282 1.000 51.025 ? 213 ALA A CA  1 ? 
ATOM   1093 C C   . ALA A 1 187 ? -5.944  -21.535 -18.161 1.000 49.920 ? 213 ALA A C   1 ? 
ATOM   1094 O O   . ALA A 1 187 ? -6.113  -22.763 -17.877 1.000 44.603 ? 213 ALA A O   1 ? 
ATOM   1095 C CB  . ALA A 1 187 ? -5.603  -19.829 -16.339 1.000 52.705 ? 213 ALA A CB  1 ? 
ATOM   1096 N N   . GLY A 1 188 ? -5.299  -21.089 -19.246 1.000 58.000 ? 214 GLY A N   1 ? 
ATOM   1097 C CA  . GLY A 1 188 ? -4.416  -21.930 -20.079 1.000 53.788 ? 214 GLY A CA  1 ? 
ATOM   1098 C C   . GLY A 1 188 ? -5.168  -22.850 -21.025 1.000 56.678 ? 214 GLY A C   1 ? 
ATOM   1099 O O   . GLY A 1 188 ? -4.502  -23.662 -21.659 1.000 56.312 ? 214 GLY A O   1 ? 
ATOM   1100 N N   . GLY A 1 189 ? -6.501  -22.741 -21.133 1.000 57.253 ? 215 GLY A N   1 ? 
ATOM   1101 C CA  . GLY A 1 189 ? -7.334  -23.645 -21.961 1.000 54.861 ? 215 GLY A CA  1 ? 
ATOM   1102 C C   . GLY A 1 189 ? -8.029  -24.724 -21.137 1.000 53.532 ? 215 GLY A C   1 ? 
ATOM   1103 O O   . GLY A 1 189 ? -8.634  -25.621 -21.743 1.000 48.479 ? 215 GLY A O   1 ? 
ATOM   1104 N N   . ALA A 1 190 ? -7.918  -24.664 -19.804 1.000 45.067 ? 216 ALA A N   1 ? 
ATOM   1105 C CA  . ALA A 1 190 ? -8.494  -25.653 -18.865 1.000 43.222 ? 216 ALA A CA  1 ? 
ATOM   1106 C C   . ALA A 1 190 ? -10.017 -25.656 -19.097 1.000 41.918 ? 216 ALA A C   1 ? 
ATOM   1107 O O   . ALA A 1 190 ? -10.560 -24.558 -19.244 1.000 34.157 ? 216 ALA A O   1 ? 
ATOM   1108 C CB  . ALA A 1 190 ? -8.171  -25.271 -17.435 1.000 41.631 ? 216 ALA A CB  1 ? 
ATOM   1109 N N   . GLN A 1 191 ? -10.656 -26.820 -19.192 1.000 40.471 ? 217 GLN A N   1 ? 
ATOM   1110 C CA  . GLN A 1 191 ? -12.127 -26.875 -19.429 1.000 42.643 ? 217 GLN A CA  1 ? 
ATOM   1111 C C   . GLN A 1 191 ? -12.870 -27.494 -18.239 1.000 38.066 ? 217 GLN A C   1 ? 
ATOM   1112 O O   . GLN A 1 191 ? -12.487 -28.618 -17.769 1.000 40.096 ? 217 GLN A O   1 ? 
ATOM   1113 C CB  . GLN A 1 191 ? -12.435 -27.665 -20.696 1.000 42.289 ? 217 GLN A CB  1 ? 
ATOM   1114 C CG  . GLN A 1 191 ? -11.742 -27.144 -21.951 1.000 48.492 ? 217 GLN A CG  1 ? 
ATOM   1115 C CD  . GLN A 1 191 ? -12.295 -27.839 -23.175 1.000 52.129 ? 217 GLN A CD  1 ? 
ATOM   1116 O OE1 . GLN A 1 191 ? -13.384 -27.515 -23.644 1.000 53.983 ? 217 GLN A OE1 1 ? 
ATOM   1117 N NE2 . GLN A 1 191 ? -11.605 -28.877 -23.624 1.000 51.289 ? 217 GLN A NE2 1 ? 
ATOM   1118 N N   . ALA A 1 192 ? -14.021 -26.890 -17.911 1.000 39.772 ? 218 ALA A N   1 ? 
ATOM   1119 C CA  . ALA A 1 192 ? -14.973 -27.393 -16.897 1.000 38.367 ? 218 ALA A CA  1 ? 
ATOM   1120 C C   . ALA A 1 192 ? -15.226 -28.902 -17.062 1.000 33.642 ? 218 ALA A C   1 ? 
ATOM   1121 O O   . ALA A 1 192 ? -15.303 -29.573 -16.049 1.000 35.907 ? 218 ALA A O   1 ? 
ATOM   1122 C CB  . ALA A 1 192 ? -16.258 -26.597 -16.961 1.000 44.957 ? 218 ALA A CB  1 ? 
ATOM   1123 N N   . LYS A 1 193 ? -15.403 -29.418 -18.280 1.000 34.463 ? 219 LYS A N   1 ? 
ATOM   1124 C CA  . LYS A 1 193 ? -15.777 -30.851 -18.517 1.000 36.755 ? 219 LYS A CA  1 ? 
ATOM   1125 C C   . LYS A 1 193 ? -14.675 -31.833 -18.102 1.000 33.730 ? 219 LYS A C   1 ? 
ATOM   1126 O O   . LYS A 1 193 ? -14.937 -33.072 -18.002 1.000 34.396 ? 219 LYS A O   1 ? 
ATOM   1127 C CB  . LYS A 1 193 ? -16.130 -31.042 -19.992 1.000 39.052 ? 219 LYS A CB  1 ? 
ATOM   1128 C CG  . LYS A 1 193 ? -15.006 -30.768 -20.981 1.000 47.547 ? 219 LYS A CG  1 ? 
ATOM   1129 C CD  . LYS A 1 193 ? -15.138 -31.594 -22.247 1.000 55.404 ? 219 LYS A CD  1 ? 
ATOM   1130 C CE  . LYS A 1 193 ? -14.260 -31.115 -23.384 1.000 67.862 ? 219 LYS A CE  1 ? 
ATOM   1131 N NZ  . LYS A 1 193 ? -14.945 -30.059 -24.170 1.000 76.531 ? 219 LYS A NZ  1 ? 
ATOM   1132 N N   . ASN A 1 194 ? -13.465 -31.321 -17.894 1.000 35.945 ? 220 ASN A N   1 ? 
ATOM   1133 C CA  . ASN A 1 194 ? -12.283 -32.128 -17.515 1.000 38.993 ? 220 ASN A CA  1 ? 
ATOM   1134 C C   . ASN A 1 194 ? -11.910 -31.937 -16.030 1.000 39.719 ? 220 ASN A C   1 ? 
ATOM   1135 O O   . ASN A 1 194 ? -10.813 -32.406 -15.632 1.000 39.911 ? 220 ASN A O   1 ? 
ATOM   1136 C CB  . ASN A 1 194 ? -11.113 -31.750 -18.415 1.000 35.429 ? 220 ASN A CB  1 ? 
ATOM   1137 C CG  . ASN A 1 194 ? -11.322 -32.129 -19.861 1.000 38.224 ? 220 ASN A CG  1 ? 
ATOM   1138 O OD1 . ASN A 1 194 ? -10.874 -31.406 -20.743 1.000 47.168 ? 220 ASN A OD1 1 ? 
ATOM   1139 N ND2 . ASN A 1 194 ? -11.939 -33.267 -20.108 1.000 37.663 ? 220 ASN A ND2 1 ? 
ATOM   1140 N N   . ILE A 1 195 ? -12.781 -31.312 -15.234 1.000 38.022 ? 221 ILE A N   1 ? 
ATOM   1141 C CA  . ILE A 1 195 ? -12.598 -31.135 -13.762 1.000 34.790 ? 221 ILE A CA  1 ? 
ATOM   1142 C C   . ILE A 1 195 ? -13.636 -31.970 -13.034 1.000 38.488 ? 221 ILE A C   1 ? 
ATOM   1143 O O   . ILE A 1 195 ? -14.848 -31.831 -13.383 1.000 36.541 ? 221 ILE A O   1 ? 
ATOM   1144 C CB  . ILE A 1 195 ? -12.670 -29.643 -13.398 1.000 33.621 ? 221 ILE A CB  1 ? 
ATOM   1145 C CG1 . ILE A 1 195 ? -11.578 -28.881 -14.157 1.000 33.275 ? 221 ILE A CG1 1 ? 
ATOM   1146 C CG2 . ILE A 1 195 ? -12.614 -29.445 -11.883 1.000 31.968 ? 221 ILE A CG2 1 ? 
ATOM   1147 C CD1 . ILE A 1 195 ? -11.665 -27.349 -14.088 1.000 32.049 ? 221 ILE A CD1 1 ? 
ATOM   1148 N N   . PHE A 1 196 ? -13.196 -32.786 -12.075 1.000 31.578 ? 222 PHE A N   1 ? 
ATOM   1149 C CA  . PHE A 1 196 ? -14.072 -33.623 -11.227 1.000 34.776 ? 222 PHE A CA  1 ? 
ATOM   1150 C C   . PHE A 1 196 ? -13.775 -33.393 -9.752  1.000 35.165 ? 222 PHE A C   1 ? 
ATOM   1151 O O   . PHE A 1 196 ? -12.605 -33.477 -9.317  1.000 35.730 ? 222 PHE A O   1 ? 
ATOM   1152 C CB  . PHE A 1 196 ? -13.950 -35.085 -11.642 1.000 32.649 ? 222 PHE A CB  1 ? 
ATOM   1153 C CG  . PHE A 1 196 ? -14.110 -35.241 -13.126 1.000 36.746 ? 222 PHE A CG  1 ? 
ATOM   1154 C CD1 . PHE A 1 196 ? -13.024 -35.092 -13.982 1.000 40.093 ? 222 PHE A CD1 1 ? 
ATOM   1155 C CD2 . PHE A 1 196 ? -15.356 -35.519 -13.673 1.000 39.104 ? 222 PHE A CD2 1 ? 
ATOM   1156 C CE1 . PHE A 1 196 ? -13.184 -35.232 -15.357 1.000 38.574 ? 222 PHE A CE1 1 ? 
ATOM   1157 C CE2 . PHE A 1 196 ? -15.514 -35.665 -15.052 1.000 38.277 ? 222 PHE A CE2 1 ? 
ATOM   1158 C CZ  . PHE A 1 196 ? -14.424 -35.537 -15.882 1.000 40.920 ? 222 PHE A CZ  1 ? 
ATOM   1159 N N   . TRP A 1 197 ? -14.828 -33.132 -8.987  1.000 29.463 ? 223 TRP A N   1 ? 
ATOM   1160 C CA  . TRP A 1 197 ? -14.762 -33.001 -7.514  1.000 29.162 ? 223 TRP A CA  1 ? 
ATOM   1161 C C   . TRP A 1 197 ? -15.563 -34.115 -6.882  1.000 36.053 ? 223 TRP A C   1 ? 
ATOM   1162 O O   . TRP A 1 197 ? -16.811 -34.081 -7.053  1.000 33.695 ? 223 TRP A O   1 ? 
ATOM   1163 C CB  . TRP A 1 197 ? -15.284 -31.652 -7.053  1.000 30.472 ? 223 TRP A CB  1 ? 
ATOM   1164 C CG  . TRP A 1 197 ? -14.697 -30.437 -7.688  1.000 33.124 ? 223 TRP A CG  1 ? 
ATOM   1165 C CD1 . TRP A 1 197 ? -15.010 -29.900 -8.897  1.000 38.257 ? 223 TRP A CD1 1 ? 
ATOM   1166 C CD2 . TRP A 1 197 ? -13.779 -29.512 -7.068  1.000 32.506 ? 223 TRP A CD2 1 ? 
ATOM   1167 N NE1 . TRP A 1 197 ? -14.356 -28.707 -9.079  1.000 36.759 ? 223 TRP A NE1 1 ? 
ATOM   1168 C CE2 . TRP A 1 197 ? -13.568 -28.461 -7.988  1.000 32.974 ? 223 TRP A CE2 1 ? 
ATOM   1169 C CE3 . TRP A 1 197 ? -13.091 -29.490 -5.848  1.000 33.753 ? 223 TRP A CE3 1 ? 
ATOM   1170 C CZ2 . TRP A 1 197 ? -12.696 -27.400 -7.727  1.000 35.906 ? 223 TRP A CZ2 1 ? 
ATOM   1171 C CZ3 . TRP A 1 197 ? -12.225 -28.448 -5.592  1.000 36.989 ? 223 TRP A CZ3 1 ? 
ATOM   1172 C CH2 . TRP A 1 197 ? -12.076 -27.388 -6.494  1.000 34.146 ? 223 TRP A CH2 1 ? 
ATOM   1173 N N   . GLN A 1 198 ? -14.881 -35.055 -6.223  1.000 31.752 ? 224 GLN A N   1 ? 
ATOM   1174 C CA  . GLN A 1 198 ? -15.503 -36.198 -5.517  1.000 34.953 ? 224 GLN A CA  1 ? 
ATOM   1175 C C   . GLN A 1 198 ? -15.488 -35.888 -4.031  1.000 38.843 ? 224 GLN A C   1 ? 
ATOM   1176 O O   . GLN A 1 198 ? -14.400 -35.694 -3.475  1.000 32.753 ? 224 GLN A O   1 ? 
ATOM   1177 C CB  . GLN A 1 198 ? -14.813 -37.514 -5.845  1.000 34.376 ? 224 GLN A CB  1 ? 
ATOM   1178 C CG  . GLN A 1 198 ? -15.245 -38.666 -4.947  1.000 39.098 ? 224 GLN A CG  1 ? 
ATOM   1179 C CD  . GLN A 1 198 ? -14.360 -38.768 -3.717  1.000 45.761 ? 224 GLN A CD  1 ? 
ATOM   1180 O OE1 . GLN A 1 198 ? -13.130 -38.756 -3.811  1.000 39.777 ? 224 GLN A OE1 1 ? 
ATOM   1181 N NE2 . GLN A 1 198 ? -14.975 -38.866 -2.552  1.000 38.249 ? 224 GLN A NE2 1 ? 
ATOM   1182 N N   . THR A 1 199 ? -16.661 -35.839 -3.393  1.000 31.649 ? 225 THR A N   1 ? 
ATOM   1183 C CA  . THR A 1 199 ? -16.763 -35.450 -1.961  1.000 33.015 ? 225 THR A CA  1 ? 
ATOM   1184 C C   . THR A 1 199 ? -17.551 -36.497 -1.192  1.000 41.373 ? 225 THR A C   1 ? 
ATOM   1185 O O   . THR A 1 199 ? -18.700 -36.742 -1.588  1.000 35.132 ? 225 THR A O   1 ? 
ATOM   1186 C CB  . THR A 1 199 ? -17.338 -34.043 -1.804  1.000 34.452 ? 225 THR A CB  1 ? 
ATOM   1187 O OG1 . THR A 1 199 ? -18.763 -34.055 -2.034  1.000 41.406 ? 225 THR A OG1 1 ? 
ATOM   1188 C CG2 . THR A 1 199 ? -16.684 -33.128 -2.795  1.000 35.807 ? 225 THR A CG2 1 ? 
ATOM   1189 N N   . ALA A 1 200 ? -16.965 -37.045 -0.119  1.000 38.492 ? 226 ALA A N   1 ? 
ATOM   1190 C CA  . ALA A 1 200 ? -17.621 -38.032 0.769   1.000 44.598 ? 226 ALA A CA  1 ? 
ATOM   1191 C C   . ALA A 1 200 ? -18.746 -37.361 1.574   1.000 42.037 ? 226 ALA A C   1 ? 
ATOM   1192 O O   . ALA A 1 200 ? -19.707 -38.055 1.902   1.000 45.724 ? 226 ALA A O   1 ? 
ATOM   1193 C CB  . ALA A 1 200 ? -16.613 -38.674 1.685   1.000 43.666 ? 226 ALA A CB  1 ? 
ATOM   1194 N N   . GLY A 1 201 ? -18.604 -36.074 1.870   1.000 38.381 ? 227 GLY A N   1 ? 
ATOM   1195 C CA  . GLY A 1 201 ? -19.556 -35.231 2.606   1.000 47.331 ? 227 GLY A CA  1 ? 
ATOM   1196 C C   . GLY A 1 201 ? -20.224 -34.207 1.708   1.000 47.360 ? 227 GLY A C   1 ? 
ATOM   1197 O O   . GLY A 1 201 ? -20.013 -34.216 0.484   1.000 50.492 ? 227 GLY A O   1 ? 
ATOM   1198 N N   . ALA A 1 202 ? -20.933 -33.278 2.311   1.000 43.220 ? 228 ALA A N   1 ? 
ATOM   1199 C CA  . ALA A 1 202 ? -21.797 -32.298 1.628   1.000 46.891 ? 228 ALA A CA  1 ? 
ATOM   1200 C C   . ALA A 1 202 ? -20.966 -31.166 1.051   1.000 43.911 ? 228 ALA A C   1 ? 
ATOM   1201 O O   . ALA A 1 202 ? -20.009 -30.749 1.678   1.000 41.161 ? 228 ALA A O   1 ? 
ATOM   1202 C CB  . ALA A 1 202 ? -22.833 -31.746 2.591   1.000 48.474 ? 228 ALA A CB  1 ? 
ATOM   1203 N N   . VAL A 1 203 ? -21.427 -30.613 -0.064  1.000 33.357 ? 229 VAL A N   1 ? 
ATOM   1204 C CA  . VAL A 1 203 ? -20.864 -29.405 -0.708  1.000 35.182 ? 229 VAL A CA  1 ? 
ATOM   1205 C C   . VAL A 1 203 ? -21.710 -28.198 -0.355  1.000 38.562 ? 229 VAL A C   1 ? 
ATOM   1206 O O   . VAL A 1 203 ? -22.984 -28.302 -0.437  1.000 47.423 ? 229 VAL A O   1 ? 
ATOM   1207 C CB  . VAL A 1 203 ? -20.793 -29.621 -2.229  1.000 33.875 ? 229 VAL A CB  1 ? 
ATOM   1208 C CG1 . VAL A 1 203 ? -20.306 -28.367 -2.947  1.000 35.793 ? 229 VAL A CG1 1 ? 
ATOM   1209 C CG2 . VAL A 1 203 ? -19.953 -30.843 -2.558  1.000 38.915 ? 229 VAL A CG2 1 ? 
ATOM   1210 N N   . THR A 1 204 ? -21.079 -27.069 -0.093  1.000 34.449 ? 230 THR A N   1 ? 
ATOM   1211 C CA  . THR A 1 204 ? -21.766 -25.787 0.168   1.000 36.798 ? 230 THR A CA  1 ? 
ATOM   1212 C C   . THR A 1 204 ? -21.054 -24.671 -0.562  1.000 42.286 ? 230 THR A C   1 ? 
ATOM   1213 O O   . THR A 1 204 ? -19.912 -24.330 -0.169  1.000 43.808 ? 230 THR A O   1 ? 
ATOM   1214 C CB  . THR A 1 204 ? -21.865 -25.488 1.671   1.000 41.289 ? 230 THR A CB  1 ? 
ATOM   1215 O OG1 . THR A 1 204 ? -22.557 -26.585 2.261   1.000 45.657 ? 230 THR A OG1 1 ? 
ATOM   1216 C CG2 . THR A 1 204 ? -22.595 -24.201 1.985   1.000 44.013 ? 230 THR A CG2 1 ? 
ATOM   1217 N N   . LEU A 1 205 ? -21.732 -24.094 -1.546  1.000 35.814 ? 231 LEU A N   1 ? 
ATOM   1218 C CA  . LEU A 1 205 ? -21.238 -22.992 -2.364  1.000 38.692 ? 231 LEU A CA  1 ? 
ATOM   1219 C C   . LEU A 1 205 ? -21.921 -21.717 -1.908  1.000 43.505 ? 231 LEU A C   1 ? 
ATOM   1220 O O   . LEU A 1 205 ? -23.150 -21.552 -2.092  1.000 40.096 ? 231 LEU A O   1 ? 
ATOM   1221 C CB  . LEU A 1 205 ? -21.503 -23.339 -3.828  1.000 41.142 ? 231 LEU A CB  1 ? 
ATOM   1222 C CG  . LEU A 1 205 ? -20.983 -24.724 -4.194  1.000 42.996 ? 231 LEU A CG  1 ? 
ATOM   1223 C CD1 . LEU A 1 205 ? -21.240 -25.040 -5.671  1.000 44.561 ? 231 LEU A CD1 1 ? 
ATOM   1224 C CD2 . LEU A 1 205 ? -19.492 -24.815 -3.856  1.000 44.456 ? 231 LEU A CD2 1 ? 
ATOM   1225 N N   . GLY A 1 206 ? -21.109 -20.806 -1.398  1.000 45.176 ? 232 GLY A N   1 ? 
ATOM   1226 C CA  . GLY A 1 206 ? -21.575 -19.555 -0.802  1.000 48.158 ? 232 GLY A CA  1 ? 
ATOM   1227 C C   . GLY A 1 206 ? -22.253 -18.677 -1.811  1.000 49.749 ? 232 GLY A C   1 ? 
ATOM   1228 O O   . GLY A 1 206 ? -22.041 -18.854 -3.058  1.000 41.877 ? 232 GLY A O   1 ? 
ATOM   1229 N N   . SER A 1 207 ? -23.000 -17.724 -1.263  1.000 49.916 ? 233 SER A N   1 ? 
ATOM   1230 C CA  . SER A 1 207 ? -23.807 -16.749 -2.019  1.000 50.188 ? 233 SER A CA  1 ? 
ATOM   1231 C C   . SER A 1 207 ? -22.900 -16.039 -2.999  1.000 46.545 ? 233 SER A C   1 ? 
ATOM   1232 O O   . SER A 1 207 ? -21.838 -15.543 -2.607  1.000 46.830 ? 233 SER A O   1 ? 
ATOM   1233 C CB  . SER A 1 207 ? -24.490 -15.759 -1.116  1.000 55.367 ? 233 SER A CB  1 ? 
ATOM   1234 O OG  . SER A 1 207 ? -23.605 -14.670 -0.890  1.000 64.399 ? 233 SER A OG  1 ? 
ATOM   1235 N N   . THR A 1 208 ? -23.321 -15.987 -4.250  1.000 42.942 ? 234 THR A N   1 ? 
ATOM   1236 C CA  . THR A 1 208 ? -22.671 -15.176 -5.298  1.000 46.675 ? 234 THR A CA  1 ? 
ATOM   1237 C C   . THR A 1 208 ? -21.319 -15.817 -5.687  1.000 42.248 ? 234 THR A C   1 ? 
ATOM   1238 O O   . THR A 1 208 ? -20.663 -15.237 -6.546  1.000 41.361 ? 234 THR A O   1 ? 
ATOM   1239 C CB  . THR A 1 208 ? -22.672 -13.702 -4.840  1.000 55.758 ? 234 THR A CB  1 ? 
ATOM   1240 O OG1 . THR A 1 208 ? -23.242 -12.964 -5.914  1.000 67.265 ? 234 THR A OG1 1 ? 
ATOM   1241 C CG2 . THR A 1 208 ? -21.338 -13.070 -4.512  1.000 49.699 ? 234 THR A CG2 1 ? 
ATOM   1242 N N   . SER A 1 209 ? -20.974 -17.010 -5.182  1.000 41.988 ? 235 SER A N   1 ? 
ATOM   1243 C CA  . SER A 1 209 ? -19.722 -17.706 -5.579  1.000 43.032 ? 235 SER A CA  1 ? 
ATOM   1244 C C   . SER A 1 209 ? -19.883 -18.200 -7.022  1.000 49.596 ? 235 SER A C   1 ? 
ATOM   1245 O O   . SER A 1 209 ? -21.046 -18.282 -7.456  1.000 44.765 ? 235 SER A O   1 ? 
ATOM   1246 C CB  . SER A 1 209 ? -19.375 -18.794 -4.624  1.000 43.091 ? 235 SER A CB  1 ? 
ATOM   1247 O OG  . SER A 1 209 ? -20.352 -19.799 -4.583  1.000 43.132 ? 235 SER A OG  1 ? 
ATOM   1248 N N   . HIS A 1 210 ? -18.781 -18.394 -7.767  1.000 40.224 ? 236 HIS A N   1 ? 
ATOM   1249 C CA  . HIS A 1 210 ? -18.741 -19.060 -9.097  1.000 41.082 ? 236 HIS A CA  1 ? 
ATOM   1250 C C   . HIS A 1 210 ? -17.841 -20.297 -9.079  1.000 44.407 ? 236 HIS A C   1 ? 
ATOM   1251 O O   . HIS A 1 210 ? -16.609 -20.185 -8.827  1.000 44.667 ? 236 HIS A O   1 ? 
ATOM   1252 C CB  . HIS A 1 210 ? -18.346 -18.107 -10.205 1.000 49.217 ? 236 HIS A CB  1 ? 
ATOM   1253 C CG  . HIS A 1 210 ? -18.209 -18.786 -11.531 1.000 55.516 ? 236 HIS A CG  1 ? 
ATOM   1254 N ND1 . HIS A 1 210 ? -19.317 -19.202 -12.286 1.000 49.847 ? 236 HIS A ND1 1 ? 
ATOM   1255 C CD2 . HIS A 1 210 ? -17.108 -19.113 -12.249 1.000 53.089 ? 236 HIS A CD2 1 ? 
ATOM   1256 C CE1 . HIS A 1 210 ? -18.893 -19.753 -13.401 1.000 51.511 ? 236 HIS A CE1 1 ? 
ATOM   1257 N NE2 . HIS A 1 210 ? -17.543 -19.708 -13.408 1.000 52.635 ? 236 HIS A NE2 1 ? 
ATOM   1258 N N   . PHE A 1 211 ? -18.443 -21.438 -9.398  1.000 35.862 ? 237 PHE A N   1 ? 
ATOM   1259 C CA  . PHE A 1 211 ? -17.800 -22.774 -9.385  1.000 34.487 ? 237 PHE A CA  1 ? 
ATOM   1260 C C   . PHE A 1 211 ? -17.591 -23.284 -10.813 1.000 32.297 ? 237 PHE A C   1 ? 
ATOM   1261 O O   . PHE A 1 211 ? -18.358 -22.971 -11.752 1.000 33.717 ? 237 PHE A O   1 ? 
ATOM   1262 C CB  . PHE A 1 211 ? -18.640 -23.705 -8.536  1.000 32.219 ? 237 PHE A CB  1 ? 
ATOM   1263 C CG  . PHE A 1 211 ? -17.950 -24.952 -8.063  1.000 34.763 ? 237 PHE A CG  1 ? 
ATOM   1264 C CD1 . PHE A 1 211 ? -17.211 -24.937 -6.880  1.000 39.095 ? 237 PHE A CD1 1 ? 
ATOM   1265 C CD2 . PHE A 1 211 ? -18.004 -26.120 -8.803  1.000 33.768 ? 237 PHE A CD2 1 ? 
ATOM   1266 C CE1 . PHE A 1 211 ? -16.597 -26.088 -6.409  1.000 35.359 ? 237 PHE A CE1 1 ? 
ATOM   1267 C CE2 . PHE A 1 211 ? -17.344 -27.256 -8.354  1.000 31.502 ? 237 PHE A CE2 1 ? 
ATOM   1268 C CZ  . PHE A 1 211 ? -16.676 -27.249 -7.143  1.000 31.283 ? 237 PHE A CZ  1 ? 
ATOM   1269 N N   . GLU A 1 212 ? -16.532 -24.065 -10.970 1.000 33.828 ? 238 GLU A N   1 ? 
ATOM   1270 C CA  . GLU A 1 212 ? -16.163 -24.734 -12.229 1.000 34.294 ? 238 GLU A CA  1 ? 
ATOM   1271 C C   . GLU A 1 212 ? -15.926 -26.204 -11.932 1.000 33.280 ? 238 GLU A C   1 ? 
ATOM   1272 O O   . GLU A 1 212 ? -15.149 -26.485 -11.013 1.000 35.777 ? 238 GLU A O   1 ? 
ATOM   1273 C CB  . GLU A 1 212 ? -14.908 -24.091 -12.813 1.000 36.990 ? 238 GLU A CB  1 ? 
ATOM   1274 C CG  . GLU A 1 212 ? -15.168 -22.656 -13.248 1.000 38.291 ? 238 GLU A CG  1 ? 
ATOM   1275 C CD  . GLU A 1 212 ? -15.863 -22.509 -14.589 1.000 40.082 ? 238 GLU A CD  1 ? 
ATOM   1276 O OE1 . GLU A 1 212 ? -15.959 -23.506 -15.323 1.000 41.559 ? 238 GLU A OE1 1 ? 
ATOM   1277 O OE2 . GLU A 1 212 ? -16.312 -21.396 -14.890 1.000 43.388 ? 238 GLU A OE2 1 ? 
ATOM   1278 N N   . GLY A 1 213 ? -16.547 -27.079 -12.715 1.000 32.621 ? 239 GLY A N   1 ? 
ATOM   1279 C CA  . GLY A 1 213 ? -16.282 -28.530 -12.719 1.000 31.369 ? 239 GLY A CA  1 ? 
ATOM   1280 C C   . GLY A 1 213 ? -17.514 -29.349 -12.351 1.000 33.019 ? 239 GLY A C   1 ? 
ATOM   1281 O O   . GLY A 1 213 ? -18.423 -28.786 -11.829 1.000 36.041 ? 239 GLY A O   1 ? 
ATOM   1282 N N   . ASN A 1 214 ? -17.439 -30.669 -12.556 1.000 33.851 ? 240 ASN A N   1 ? 
ATOM   1283 C CA  . ASN A 1 214 ? -18.388 -31.729 -12.139 1.000 35.023 ? 240 ASN A CA  1 ? 
ATOM   1284 C C   . ASN A 1 214 ? -18.259 -32.015 -10.639 1.000 35.764 ? 240 ASN A C   1 ? 
ATOM   1285 O O   . ASN A 1 214 ? -17.124 -32.171 -10.152 1.000 33.510 ? 240 ASN A O   1 ? 
ATOM   1286 C CB  . ASN A 1 214 ? -18.108 -33.006 -12.923 1.000 35.057 ? 240 ASN A CB  1 ? 
ATOM   1287 C CG  . ASN A 1 214 ? -18.251 -32.768 -14.406 1.000 36.732 ? 240 ASN A CG  1 ? 
ATOM   1288 O OD1 . ASN A 1 214 ? -19.339 -32.387 -14.870 1.000 34.853 ? 240 ASN A OD1 1 ? 
ATOM   1289 N ND2 . ASN A 1 214 ? -17.141 -32.915 -15.127 1.000 31.754 ? 240 ASN A ND2 1 ? 
ATOM   1290 N N   . ILE A 1 215 ? -19.382 -32.026 -9.925  1.000 28.209 ? 241 ILE A N   1 ? 
ATOM   1291 C CA  . ILE A 1 215 ? -19.437 -32.417 -8.499  1.000 27.779 ? 241 ILE A CA  1 ? 
ATOM   1292 C C   . ILE A 1 215 ? -20.079 -33.791 -8.416  1.000 35.239 ? 241 ILE A C   1 ? 
ATOM   1293 O O   . ILE A 1 215 ? -21.299 -33.976 -8.809  1.000 33.939 ? 241 ILE A O   1 ? 
ATOM   1294 C CB  . ILE A 1 215 ? -20.125 -31.350 -7.680  1.000 27.713 ? 241 ILE A CB  1 ? 
ATOM   1295 C CG1 . ILE A 1 215 ? -19.541 -29.981 -8.020  1.000 30.134 ? 241 ILE A CG1 1 ? 
ATOM   1296 C CG2 . ILE A 1 215 ? -20.131 -31.669 -6.191  1.000 31.967 ? 241 ILE A CG2 1 ? 
ATOM   1297 C CD1 . ILE A 1 215 ? -20.175 -28.846 -7.256  1.000 30.165 ? 241 ILE A CD1 1 ? 
ATOM   1298 N N   . LEU A 1 216 ? -19.291 -34.737 -7.943  1.000 32.434 ? 242 LEU A N   1 ? 
ATOM   1299 C CA  . LEU A 1 216 ? -19.794 -36.062 -7.504  1.000 34.915 ? 242 LEU A CA  1 ? 
ATOM   1300 C C   . LEU A 1 216 ? -19.838 -36.105 -5.972  1.000 42.466 ? 242 LEU A C   1 ? 
ATOM   1301 O O   . LEU A 1 216 ? -18.791 -36.311 -5.317  1.000 36.585 ? 242 LEU A O   1 ? 
ATOM   1302 C CB  . LEU A 1 216 ? -18.932 -37.146 -8.117  1.000 32.332 ? 242 LEU A CB  1 ? 
ATOM   1303 C CG  . LEU A 1 216 ? -19.029 -37.234 -9.644  1.000 37.416 ? 242 LEU A CG  1 ? 
ATOM   1304 C CD1 . LEU A 1 216 ? -17.778 -37.831 -10.224 1.000 37.311 ? 242 LEU A CD1 1 ? 
ATOM   1305 C CD2 . LEU A 1 216 ? -20.239 -38.085 -10.057 1.000 38.568 ? 242 LEU A CD2 1 ? 
ATOM   1306 N N   . SER A 1 217 ? -21.013 -35.821 -5.407  1.000 33.216 ? 243 SER A N   1 ? 
ATOM   1307 C CA  . SER A 1 217 ? -21.202 -35.767 -3.942  1.000 34.062 ? 243 SER A CA  1 ? 
ATOM   1308 C C   . SER A 1 217 ? -21.890 -37.034 -3.426  1.000 42.943 ? 243 SER A C   1 ? 
ATOM   1309 O O   . SER A 1 217 ? -22.929 -37.478 -3.997  1.000 35.643 ? 243 SER A O   1 ? 
ATOM   1310 C CB  . SER A 1 217 ? -21.887 -34.526 -3.510  1.000 33.754 ? 243 SER A CB  1 ? 
ATOM   1311 O OG  . SER A 1 217 ? -22.081 -34.543 -2.105  1.000 39.573 ? 243 SER A OG  1 ? 
ATOM   1312 N N   . GLN A 1 218 ? -21.338 -37.597 -2.351  1.000 39.357 ? 244 GLN A N   1 ? 
ATOM   1313 C CA  . GLN A 1 218 ? -21.894 -38.815 -1.728  1.000 42.260 ? 244 GLN A CA  1 ? 
ATOM   1314 C C   . GLN A 1 218 ? -23.160 -38.420 -0.956  1.000 36.582 ? 244 GLN A C   1 ? 
ATOM   1315 O O   . GLN A 1 218 ? -23.941 -39.287 -0.725  1.000 39.003 ? 244 GLN A O   1 ? 
ATOM   1316 C CB  . GLN A 1 218 ? -20.886 -39.502 -0.804  1.000 46.326 ? 244 GLN A CB  1 ? 
ATOM   1317 C CG  . GLN A 1 218 ? -21.280 -40.932 -0.433  1.000 47.423 ? 244 GLN A CG  1 ? 
ATOM   1318 C CD  . GLN A 1 218 ? -20.213 -41.674 0.338   1.000 47.104 ? 244 GLN A CD  1 ? 
ATOM   1319 O OE1 . GLN A 1 218 ? -19.589 -41.151 1.269   1.000 49.481 ? 244 GLN A OE1 1 ? 
ATOM   1320 N NE2 . GLN A 1 218 ? -20.000 -42.914 -0.051  1.000 47.455 ? 244 GLN A NE2 1 ? 
ATOM   1321 N N   . THR A 1 219 ? -23.284 -37.171 -0.558  1.000 38.909 ? 245 THR A N   1 ? 
ATOM   1322 C CA  . THR A 1 219 ? -24.498 -36.575 0.059   1.000 48.833 ? 245 THR A CA  1 ? 
ATOM   1323 C C   . THR A 1 219 ? -24.980 -35.407 -0.816  1.000 34.892 ? 245 THR A C   1 ? 
ATOM   1324 O O   . THR A 1 219 ? -25.251 -35.631 -2.011  1.000 41.600 ? 245 THR A O   1 ? 
ATOM   1325 C CB  . THR A 1 219 ? -24.240 -36.258 1.549   1.000 45.809 ? 245 THR A CB  1 ? 
ATOM   1326 O OG1 . THR A 1 219 ? -23.337 -35.173 1.743   1.000 48.085 ? 245 THR A OG1 1 ? 
ATOM   1327 C CG2 . THR A 1 219 ? -23.727 -37.470 2.284   1.000 42.118 ? 245 THR A CG2 1 ? 
ATOM   1328 N N   . GLY A 1 220 ? -25.056 -34.203 -0.271  1.000 36.776 ? 246 GLY A N   1 ? 
ATOM   1329 C CA  . GLY A 1 220 ? -25.814 -33.067 -0.808  1.000 38.242 ? 246 GLY A CA  1 ? 
ATOM   1330 C C   . GLY A 1 220 ? -24.915 -32.058 -1.441  1.000 39.399 ? 246 GLY A C   1 ? 
ATOM   1331 O O   . GLY A 1 220 ? -23.697 -32.069 -1.187  1.000 40.238 ? 246 GLY A O   1 ? 
ATOM   1332 N N   . ILE A 1 221 ? -25.482 -31.309 -2.356  1.000 33.977 ? 247 ILE A N   1 ? 
ATOM   1333 C CA  . ILE A 1 221 ? -24.845 -30.125 -2.978  1.000 37.314 ? 247 ILE A CA  1 ? 
ATOM   1334 C C   . ILE A 1 221 ? -25.838 -29.007 -2.756  1.000 37.020 ? 247 ILE A C   1 ? 
ATOM   1335 O O   . ILE A 1 221 ? -26.980 -29.096 -3.324  1.000 39.860 ? 247 ILE A O   1 ? 
ATOM   1336 C CB  . ILE A 1 221 ? -24.502 -30.370 -4.469  1.000 35.493 ? 247 ILE A CB  1 ? 
ATOM   1337 C CG1 . ILE A 1 221 ? -23.770 -31.698 -4.670  1.000 33.291 ? 247 ILE A CG1 1 ? 
ATOM   1338 C CG2 . ILE A 1 221 ? -23.771 -29.190 -5.055  1.000 37.722 ? 247 ILE A CG2 1 ? 
ATOM   1339 C CD1 . ILE A 1 221 ? -23.592 -32.107 -6.112  1.000 34.655 ? 247 ILE A CD1 1 ? 
ATOM   1340 N N   . ASN A 1 222 ? -25.413 -27.989 -2.025  1.000 36.385 ? 248 ASN A N   1 ? 
ATOM   1341 C CA  . ASN A 1 222 ? -26.244 -26.903 -1.468  1.000 40.593 ? 248 ASN A CA  1 ? 
ATOM   1342 C C   . ASN A 1 222 ? -25.629 -25.613 -1.987  1.000 41.138 ? 248 ASN A C   1 ? 
ATOM   1343 O O   . ASN A 1 222 ? -24.442 -25.334 -1.684  1.000 50.245 ? 248 ASN A O   1 ? 
ATOM   1344 C CB  . ASN A 1 222 ? -26.383 -27.056 0.067   1.000 36.617 ? 248 ASN A CB  1 ? 
ATOM   1345 C CG  . ASN A 1 222 ? -26.780 -28.461 0.475   1.000 43.710 ? 248 ASN A CG  1 ? 
ATOM   1346 O OD1 . ASN A 1 222 ? -27.835 -28.976 0.066   1.000 50.376 ? 248 ASN A OD1 1 ? 
ATOM   1347 N ND2 . ASN A 1 222 ? -25.919 -29.159 1.224   1.000 39.501 ? 248 ASN A ND2 1 ? 
ATOM   1348 N N   . MET A 1 223 ? -26.362 -24.879 -2.818  1.000 34.337 ? 249 MET A N   1 ? 
ATOM   1349 C CA  . MET A 1 223 ? -25.932 -23.559 -3.317  1.000 33.139 ? 249 MET A CA  1 ? 
ATOM   1350 C C   . MET A 1 223 ? -26.766 -22.492 -2.626  1.000 40.084 ? 249 MET A C   1 ? 
ATOM   1351 O O   . MET A 1 223 ? -27.927 -22.784 -2.222  1.000 44.008 ? 249 MET A O   1 ? 
ATOM   1352 C CB  . MET A 1 223 ? -26.106 -23.420 -4.828  1.000 34.092 ? 249 MET A CB  1 ? 
ATOM   1353 C CG  . MET A 1 223 ? -25.296 -24.415 -5.623  1.000 43.147 ? 249 MET A CG  1 ? 
ATOM   1354 S SD  . MET A 1 223 ? -25.245 -24.164 -7.435  1.000 43.128 ? 249 MET A SD  1 ? 
ATOM   1355 C CE  . MET A 1 223 ? -24.396 -22.618 -7.695  1.000 36.568 ? 249 MET A CE  1 ? 
ATOM   1356 N N   . LYS A 1 224 ? -26.211 -21.280 -2.582  1.000 42.430 ? 250 LYS A N   1 ? 
ATOM   1357 C CA  . LYS A 1 224 ? -26.794 -20.128 -1.873  1.000 48.533 ? 250 LYS A CA  1 ? 
ATOM   1358 C C   . LYS A 1 224 ? -27.024 -19.020 -2.883  1.000 48.886 ? 250 LYS A C   1 ? 
ATOM   1359 O O   . LYS A 1 224 ? -26.471 -19.070 -3.990  1.000 51.682 ? 250 LYS A O   1 ? 
ATOM   1360 C CB  . LYS A 1 224 ? -25.886 -19.634 -0.734  1.000 50.802 ? 250 LYS A CB  1 ? 
ATOM   1361 C CG  . LYS A 1 224 ? -25.542 -20.666 0.320   1.000 47.370 ? 250 LYS A CG  1 ? 
ATOM   1362 C CD  . LYS A 1 224 ? -26.757 -21.114 1.079   1.000 51.919 ? 250 LYS A CD  1 ? 
ATOM   1363 C CE  . LYS A 1 224 ? -26.535 -22.408 1.807   1.000 55.061 ? 250 LYS A CE  1 ? 
ATOM   1364 N NZ  . LYS A 1 224 ? -27.840 -23.034 2.085   1.000 64.337 ? 250 LYS A NZ  1 ? 
ATOM   1365 N N   . THR A 1 225 ? -27.779 -18.027 -2.441  1.000 50.407 ? 251 THR A N   1 ? 
ATOM   1366 C CA  . THR A 1 225 ? -28.290 -16.880 -3.221  1.000 49.435 ? 251 THR A CA  1 ? 
ATOM   1367 C C   . THR A 1 225 ? -27.333 -16.427 -4.331  1.000 48.571 ? 251 THR A C   1 ? 
ATOM   1368 O O   . THR A 1 225 ? -26.276 -15.864 -4.053  1.000 48.564 ? 251 THR A O   1 ? 
ATOM   1369 C CB  . THR A 1 225 ? -28.691 -15.783 -2.229  1.000 49.345 ? 251 THR A CB  1 ? 
ATOM   1370 O OG1 . THR A 1 225 ? -29.627 -16.441 -1.365  1.000 47.047 ? 251 THR A OG1 1 ? 
ATOM   1371 C CG2 . THR A 1 225 ? -29.265 -14.571 -2.925  1.000 51.643 ? 251 THR A CG2 1 ? 
ATOM   1372 N N   . ALA A 1 226 ? -27.745 -16.624 -5.582  1.000 43.089 ? 252 ALA A N   1 ? 
ATOM   1373 C CA  . ALA A 1 226 ? -27.110 -16.057 -6.780  1.000 44.379 ? 252 ALA A CA  1 ? 
ATOM   1374 C C   . ALA A 1 226 ? -25.723 -16.676 -7.014  1.000 35.172 ? 252 ALA A C   1 ? 
ATOM   1375 O O   . ALA A 1 226 ? -25.066 -16.157 -7.862  1.000 40.107 ? 252 ALA A O   1 ? 
ATOM   1376 C CB  . ALA A 1 226 ? -27.033 -14.551 -6.661  1.000 46.439 ? 252 ALA A CB  1 ? 
ATOM   1377 N N   . ALA A 1 227 ? -25.348 -17.772 -6.352  1.000 44.838 ? 253 ALA A N   1 ? 
ATOM   1378 C CA  . ALA A 1 227 ? -24.163 -18.584 -6.732  1.000 44.420 ? 253 ALA A CA  1 ? 
ATOM   1379 C C   . ALA A 1 227 ? -24.388 -19.159 -8.149  1.000 45.442 ? 253 ALA A C   1 ? 
ATOM   1380 O O   . ALA A 1 227 ? -25.550 -19.423 -8.532  1.000 38.869 ? 253 ALA A O   1 ? 
ATOM   1381 C CB  . ALA A 1 227 ? -23.934 -19.669 -5.710  1.000 41.442 ? 253 ALA A CB  1 ? 
ATOM   1382 N N   . SER A 1 228 ? -23.325 -19.307 -8.929  1.000 39.293 ? 254 SER A N   1 ? 
ATOM   1383 C CA  . SER A 1 228 ? -23.351 -19.951 -10.262 1.000 41.055 ? 254 SER A CA  1 ? 
ATOM   1384 C C   . SER A 1 228 ? -22.398 -21.145 -10.318 1.000 43.667 ? 254 SER A C   1 ? 
ATOM   1385 O O   . SER A 1 228 ? -21.386 -21.186 -9.597  1.000 39.399 ? 254 SER A O   1 ? 
ATOM   1386 C CB  . SER A 1 228 ? -23.045 -18.979 -11.335 1.000 42.813 ? 254 SER A CB  1 ? 
ATOM   1387 O OG  . SER A 1 228 ? -21.712 -18.528 -11.216 1.000 50.890 ? 254 SER A OG  1 ? 
ATOM   1388 N N   . ILE A 1 229 ? -22.680 -22.081 -11.208 1.000 41.005 ? 255 ILE A N   1 ? 
ATOM   1389 C CA  . ILE A 1 229 ? -21.742 -23.195 -11.490 1.000 37.706 ? 255 ILE A CA  1 ? 
ATOM   1390 C C   . ILE A 1 229 ? -21.735 -23.456 -12.995 1.000 38.471 ? 255 ILE A C   1 ? 
ATOM   1391 O O   . ILE A 1 229 ? -22.814 -23.526 -13.591 1.000 37.062 ? 255 ILE A O   1 ? 
ATOM   1392 C CB  . ILE A 1 229 ? -22.122 -24.412 -10.637 1.000 34.448 ? 255 ILE A CB  1 ? 
ATOM   1393 C CG1 . ILE A 1 229 ? -21.287 -25.634 -11.020 1.000 29.554 ? 255 ILE A CG1 1 ? 
ATOM   1394 C CG2 . ILE A 1 229 ? -23.624 -24.696 -10.736 1.000 37.239 ? 255 ILE A CG2 1 ? 
ATOM   1395 C CD1 . ILE A 1 229 ? -21.330 -26.722 -10.032 1.000 32.090 ? 255 ILE A CD1 1 ? 
ATOM   1396 N N   . ASN A 1 230 ? -20.556 -23.541 -13.603 1.000 33.403 ? 256 ASN A N   1 ? 
ATOM   1397 C CA  . ASN A 1 230 ? -20.359 -24.153 -14.934 1.000 34.377 ? 256 ASN A CA  1 ? 
ATOM   1398 C C   . ASN A 1 230 ? -19.878 -25.552 -14.609 1.000 33.207 ? 256 ASN A C   1 ? 
ATOM   1399 O O   . ASN A 1 230 ? -18.705 -25.685 -14.243 1.000 35.330 ? 256 ASN A O   1 ? 
ATOM   1400 C CB  . ASN A 1 230 ? -19.348 -23.481 -15.880 1.000 46.448 ? 256 ASN A CB  1 ? 
ATOM   1401 C CG  . ASN A 1 230 ? -19.812 -22.169 -16.467 1.000 60.936 ? 256 ASN A CG  1 ? 
ATOM   1402 O OD1 . ASN A 1 230 ? -20.927 -22.065 -16.966 1.000 79.404 ? 256 ASN A OD1 1 ? 
ATOM   1403 N ND2 . ASN A 1 230 ? -18.941 -21.164 -16.459 1.000 74.169 ? 256 ASN A ND2 1 ? 
ATOM   1404 N N   . GLY A 1 231 ? -20.768 -26.531 -14.678 1.000 34.765 ? 257 GLY A N   1 ? 
ATOM   1405 C CA  . GLY A 1 231 ? -20.526 -27.885 -14.146 1.000 35.864 ? 257 GLY A CA  1 ? 
ATOM   1406 C C   . GLY A 1 231 ? -21.805 -28.678 -14.007 1.000 39.723 ? 257 GLY A C   1 ? 
ATOM   1407 O O   . GLY A 1 231 ? -22.816 -28.327 -14.644 1.000 47.613 ? 257 GLY A O   1 ? 
ATOM   1408 N N   . ARG A 1 232 ? -21.709 -29.814 -13.348 1.000 35.440 ? 258 ARG A N   1 ? 
ATOM   1409 C CA  . ARG A 1 232 ? -22.845 -30.729 -13.139 1.000 31.279 ? 258 ARG A CA  1 ? 
ATOM   1410 C C   . ARG A 1 232 ? -22.915 -30.955 -11.637 1.000 31.804 ? 258 ARG A C   1 ? 
ATOM   1411 O O   . ARG A 1 232 ? -21.868 -30.929 -11.010 1.000 31.975 ? 258 ARG A O   1 ? 
ATOM   1412 C CB  . ARG A 1 232 ? -22.617 -32.048 -13.851 1.000 31.424 ? 258 ARG A CB  1 ? 
ATOM   1413 C CG  . ARG A 1 232 ? -22.695 -31.966 -15.349 1.000 31.261 ? 258 ARG A CG  1 ? 
ATOM   1414 C CD  . ARG A 1 232 ? -22.390 -33.338 -15.850 1.000 32.730 ? 258 ARG A CD  1 ? 
ATOM   1415 N NE  . ARG A 1 232 ? -22.395 -33.330 -17.299 1.000 30.464 ? 258 ARG A NE  1 ? 
ATOM   1416 C CZ  . ARG A 1 232 ? -21.336 -33.195 -18.094 1.000 36.332 ? 258 ARG A CZ  1 ? 
ATOM   1417 N NH1 . ARG A 1 232 ? -20.105 -32.992 -17.610 1.000 33.458 ? 258 ARG A NH1 1 ? 
ATOM   1418 N NH2 . ARG A 1 232 ? -21.551 -33.245 -19.404 1.000 32.563 ? 258 ARG A NH2 1 ? 
ATOM   1419 N N   . MET A 1 233 ? -24.105 -31.028 -11.078 1.000 29.225 ? 259 MET A N   1 ? 
ATOM   1420 C CA  . MET A 1 233 ? -24.349 -31.298 -9.644  1.000 29.201 ? 259 MET A CA  1 ? 
ATOM   1421 C C   . MET A 1 233 ? -24.941 -32.700 -9.571  1.000 31.917 ? 259 MET A C   1 ? 
ATOM   1422 O O   . MET A 1 233 ? -26.139 -32.888 -9.951  1.000 29.647 ? 259 MET A O   1 ? 
ATOM   1423 C CB  . MET A 1 233 ? -25.322 -30.267 -9.102  1.000 35.912 ? 259 MET A CB  1 ? 
ATOM   1424 C CG  . MET A 1 233 ? -24.873 -28.866 -9.467  1.000 40.311 ? 259 MET A CG  1 ? 
ATOM   1425 S SD  . MET A 1 233 ? -26.072 -27.567 -9.053  1.000 43.541 ? 259 MET A SD  1 ? 
ATOM   1426 C CE  . MET A 1 233 ? -25.623 -27.564 -7.333  1.000 42.440 ? 259 MET A CE  1 ? 
ATOM   1427 N N   . MET A 1 234 ? -24.112 -33.673 -9.248  1.000 27.555 ? 260 MET A N   1 ? 
ATOM   1428 C CA  . MET A 1 234 ? -24.513 -35.104 -9.145  1.000 31.884 ? 260 MET A CA  1 ? 
ATOM   1429 C C   . MET A 1 234 ? -24.472 -35.555 -7.675  1.000 35.298 ? 260 MET A C   1 ? 
ATOM   1430 O O   . MET A 1 234 ? -23.390 -35.734 -7.094  1.000 35.907 ? 260 MET A O   1 ? 
ATOM   1431 C CB  . MET A 1 234 ? -23.654 -35.942 -10.079 1.000 31.502 ? 260 MET A CB  1 ? 
ATOM   1432 C CG  . MET A 1 234 ? -23.844 -35.583 -11.569 1.000 36.214 ? 260 MET A CG  1 ? 
ATOM   1433 S SD  . MET A 1 234 ? -22.609 -36.325 -12.646 1.000 40.981 ? 260 MET A SD  1 ? 
ATOM   1434 C CE  . MET A 1 234 ? -21.144 -35.385 -12.196 1.000 40.662 ? 260 MET A CE  1 ? 
ATOM   1435 N N   . ALA A 1 235 ? -25.627 -35.596 -7.014  1.000 29.744 ? 261 ALA A N   1 ? 
ATOM   1436 C CA  . ALA A 1 235 ? -25.710 -35.837 -5.557  1.000 32.793 ? 261 ALA A CA  1 ? 
ATOM   1437 C C   . ALA A 1 235 ? -26.388 -37.174 -5.281  1.000 43.447 ? 261 ALA A C   1 ? 
ATOM   1438 O O   . ALA A 1 235 ? -27.512 -37.409 -5.846  1.000 40.537 ? 261 ALA A O   1 ? 
ATOM   1439 C CB  . ALA A 1 235 ? -26.411 -34.711 -4.876  1.000 39.688 ? 261 ALA A CB  1 ? 
ATOM   1440 N N   . GLN A 1 236 ? -25.813 -37.968 -4.367  1.000 36.904 ? 262 GLN A N   1 ? 
ATOM   1441 C CA  . GLN A 1 236 ? -26.436 -39.258 -3.947  1.000 48.835 ? 262 GLN A CA  1 ? 
ATOM   1442 C C   . GLN A 1 236 ? -27.544 -38.982 -2.928  1.000 40.693 ? 262 GLN A C   1 ? 
ATOM   1443 O O   . GLN A 1 236 ? -28.237 -39.962 -2.598  1.000 41.987 ? 262 GLN A O   1 ? 
ATOM   1444 C CB  . GLN A 1 236 ? -25.421 -40.313 -3.489  1.000 47.101 ? 262 GLN A CB  1 ? 
ATOM   1445 C CG  . GLN A 1 236 ? -24.720 -40.984 -4.664  1.000 54.219 ? 262 GLN A CG  1 ? 
ATOM   1446 C CD  . GLN A 1 236 ? -23.363 -41.540 -4.305  1.000 61.183 ? 262 GLN A CD  1 ? 
ATOM   1447 O OE1 . GLN A 1 236 ? -23.166 -42.029 -3.203  1.000 78.104 ? 262 GLN A OE1 1 ? 
ATOM   1448 N NE2 . GLN A 1 236 ? -22.404 -41.442 -5.214  1.000 58.207 ? 262 GLN A NE2 1 ? 
ATOM   1449 N N   . THR A 1 237 ? -27.679 -37.749 -2.436  1.000 34.288 ? 263 THR A N   1 ? 
ATOM   1450 C CA  . THR A 1 237 ? -28.853 -37.273 -1.661  1.000 43.423 ? 263 THR A CA  1 ? 
ATOM   1451 C C   . THR A 1 237 ? -29.539 -36.173 -2.496  1.000 37.577 ? 263 THR A C   1 ? 
ATOM   1452 O O   . THR A 1 237 ? -29.957 -36.498 -3.624  1.000 38.524 ? 263 THR A O   1 ? 
ATOM   1453 C CB  . THR A 1 237 ? -28.526 -36.904 -0.200  1.000 48.105 ? 263 THR A CB  1 ? 
ATOM   1454 O OG1 . THR A 1 237 ? -27.657 -35.774 -0.080  1.000 44.456 ? 263 THR A OG1 1 ? 
ATOM   1455 C CG2 . THR A 1 237 ? -27.973 -38.076 0.583   1.000 43.982 ? 263 THR A CG2 1 ? 
ATOM   1456 N N   . ALA A 1 238 ? -29.589 -34.939 -2.017  1.000 35.599 ? 264 ALA A N   1 ? 
ATOM   1457 C CA  . ALA A 1 238 ? -30.313 -33.837 -2.666  1.000 44.408 ? 264 ALA A CA  1 ? 
ATOM   1458 C C   . ALA A 1 238 ? -29.408 -32.716 -3.150  1.000 44.131 ? 264 ALA A C   1 ? 
ATOM   1459 O O   . ALA A 1 238 ? -28.366 -32.446 -2.528  1.000 42.596 ? 264 ALA A O   1 ? 
ATOM   1460 C CB  . ALA A 1 238 ? -31.315 -33.251 -1.708  1.000 43.662 ? 264 ALA A CB  1 ? 
ATOM   1461 N N   . VAL A 1 239 ? -29.930 -31.977 -4.134  1.000 37.281 ? 265 VAL A N   1 ? 
ATOM   1462 C CA  . VAL A 1 239 ? -29.379 -30.675 -4.585  1.000 37.624 ? 265 VAL A CA  1 ? 
ATOM   1463 C C   . VAL A 1 239 ? -30.325 -29.634 -4.068  1.000 34.721 ? 265 VAL A C   1 ? 
ATOM   1464 O O   . VAL A 1 239 ? -31.551 -29.848 -4.271  1.000 38.018 ? 265 VAL A O   1 ? 
ATOM   1465 C CB  . VAL A 1 239 ? -29.222 -30.598 -6.120  1.000 34.200 ? 265 VAL A CB  1 ? 
ATOM   1466 C CG1 . VAL A 1 239 ? -28.810 -29.217 -6.596  1.000 34.651 ? 265 VAL A CG1 1 ? 
ATOM   1467 C CG2 . VAL A 1 239 ? -28.263 -31.648 -6.633  1.000 36.449 ? 265 VAL A CG2 1 ? 
ATOM   1468 N N   . THR A 1 240 ? -29.814 -28.513 -3.548  1.000 34.921 ? 266 THR A N   1 ? 
ATOM   1469 C CA  . THR A 1 240 ? -30.633 -27.410 -3.014  1.000 37.121 ? 266 THR A CA  1 ? 
ATOM   1470 C C   . THR A 1 240 ? -30.139 -26.138 -3.651  1.000 41.420 ? 266 THR A C   1 ? 
ATOM   1471 O O   . THR A 1 240 ? -28.923 -25.947 -3.683  1.000 41.547 ? 266 THR A O   1 ? 
ATOM   1472 C CB  . THR A 1 240 ? -30.627 -27.400 -1.461  1.000 41.176 ? 266 THR A CB  1 ? 
ATOM   1473 O OG1 . THR A 1 240 ? -29.347 -27.022 -0.930  1.000 40.107 ? 266 THR A OG1 1 ? 
ATOM   1474 C CG2 . THR A 1 240 ? -30.981 -28.751 -0.896  1.000 36.922 ? 266 THR A CG2 1 ? 
ATOM   1475 N N   . LEU A 1 241 ? -31.047 -25.297 -4.132  1.000 35.074 ? 267 LEU A N   1 ? 
ATOM   1476 C CA  . LEU A 1 241 ? -30.665 -24.085 -4.887  1.000 37.790 ? 267 LEU A CA  1 ? 
ATOM   1477 C C   . LEU A 1 241 ? -31.326 -22.891 -4.239  1.000 34.664 ? 267 LEU A C   1 ? 
ATOM   1478 O O   . LEU A 1 241 ? -32.470 -23.005 -3.799  1.000 46.282 ? 267 LEU A O   1 ? 
ATOM   1479 C CB  . LEU A 1 241 ? -31.116 -24.171 -6.356  1.000 36.456 ? 267 LEU A CB  1 ? 
ATOM   1480 C CG  . LEU A 1 241 ? -30.749 -25.450 -7.109  1.000 36.695 ? 267 LEU A CG  1 ? 
ATOM   1481 C CD1 . LEU A 1 241 ? -31.459 -25.502 -8.456  1.000 40.253 ? 267 LEU A CD1 1 ? 
ATOM   1482 C CD2 . LEU A 1 241 ? -29.236 -25.555 -7.309  1.000 42.168 ? 267 LEU A CD2 1 ? 
ATOM   1483 N N   . GLN A 1 242 ? -30.690 -21.748 -4.369  1.000 39.338 ? 268 GLN A N   1 ? 
ATOM   1484 C CA  . GLN A 1 242 ? -31.288 -20.473 -3.993  1.000 42.848 ? 268 GLN A CA  1 ? 
ATOM   1485 C C   . GLN A 1 242 ? -30.973 -19.511 -5.139  1.000 44.364 ? 268 GLN A C   1 ? 
ATOM   1486 O O   . GLN A 1 242 ? -29.839 -18.986 -5.174  1.000 42.374 ? 268 GLN A O   1 ? 
ATOM   1487 C CB  . GLN A 1 242 ? -30.775 -20.060 -2.602  1.000 39.980 ? 268 GLN A CB  1 ? 
ATOM   1488 C CG  . GLN A 1 242 ? -30.993 -21.069 -1.484  1.000 42.846 ? 268 GLN A CG  1 ? 
ATOM   1489 C CD  . GLN A 1 242 ? -30.403 -20.541 -0.186  1.000 40.486 ? 268 GLN A CD  1 ? 
ATOM   1490 O OE1 . GLN A 1 242 ? -29.710 -19.533 -0.168  1.000 44.507 ? 268 GLN A OE1 1 ? 
ATOM   1491 N NE2 . GLN A 1 242 ? -30.724 -21.168 0.919   1.000 45.467 ? 268 GLN A NE2 1 ? 
ATOM   1492 N N   . MET A 1 243 ? -31.903 -19.324 -6.096  1.000 42.569 ? 269 MET A N   1 ? 
ATOM   1493 C CA  . MET A 1 243 ? -31.723 -18.307 -7.173  1.000 45.040 ? 269 MET A CA  1 ? 
ATOM   1494 C C   . MET A 1 243 ? -30.394 -18.526 -7.934  1.000 41.897 ? 269 MET A C   1 ? 
ATOM   1495 O O   . MET A 1 243 ? -29.675 -17.541 -8.190  1.000 39.182 ? 269 MET A O   1 ? 
ATOM   1496 C CB  . MET A 1 243 ? -31.715 -16.897 -6.564  1.000 49.850 ? 269 MET A CB  1 ? 
ATOM   1497 C CG  . MET A 1 243 ? -32.940 -16.069 -6.861  1.000 63.533 ? 269 MET A CG  1 ? 
ATOM   1498 S SD  . MET A 1 243 ? -33.259 -14.847 -5.544  1.000 63.166 ? 269 MET A SD  1 ? 
ATOM   1499 C CE  . MET A 1 243 ? -34.154 -15.876 -4.383  1.000 62.411 ? 269 MET A CE  1 ? 
ATOM   1500 N N   . ASN A 1 244 ? -30.085 -19.748 -8.368  1.000 39.074 ? 270 ASN A N   1 ? 
ATOM   1501 C CA  . ASN A 1 244 ? -28.735 -20.058 -8.909  1.000 39.280 ? 270 ASN A CA  1 ? 
ATOM   1502 C C   . ASN A 1 244 ? -28.736 -20.067 -10.431 1.000 40.131 ? 270 ASN A C   1 ? 
ATOM   1503 O O   . ASN A 1 244 ? -29.770 -20.389 -11.015 1.000 38.642 ? 270 ASN A O   1 ? 
ATOM   1504 C CB  . ASN A 1 244 ? -28.260 -21.398 -8.359  1.000 38.339 ? 270 ASN A CB  1 ? 
ATOM   1505 C CG  . ASN A 1 244 ? -28.065 -21.305 -6.874  1.000 38.944 ? 270 ASN A CG  1 ? 
ATOM   1506 O OD1 . ASN A 1 244 ? -28.618 -22.135 -6.173  1.000 35.595 ? 270 ASN A OD1 1 ? 
ATOM   1507 N ND2 . ASN A 1 244 ? -27.309 -20.292 -6.423  1.000 39.769 ? 270 ASN A ND2 1 ? 
ATOM   1508 N N   . THR A 1 245 ? -27.592 -19.773 -11.039 1.000 37.776 ? 271 THR A N   1 ? 
ATOM   1509 C CA  . THR A 1 245 ? -27.337 -20.075 -12.464 1.000 37.114 ? 271 THR A CA  1 ? 
ATOM   1510 C C   . THR A 1 245 ? -26.579 -21.403 -12.525 1.000 37.992 ? 271 THR A C   1 ? 
ATOM   1511 O O   . THR A 1 245 ? -25.502 -21.496 -11.931 1.000 36.803 ? 271 THR A O   1 ? 
ATOM   1512 C CB  . THR A 1 245 ? -26.569 -18.956 -13.146 1.000 40.257 ? 271 THR A CB  1 ? 
ATOM   1513 O OG1 . THR A 1 245 ? -27.444 -17.831 -13.086 1.000 49.129 ? 271 THR A OG1 1 ? 
ATOM   1514 C CG2 . THR A 1 245 ? -26.222 -19.233 -14.594 1.000 38.209 ? 271 THR A CG2 1 ? 
ATOM   1515 N N   . VAL A 1 246 ? -27.090 -22.379 -13.241 1.000 31.507 ? 272 VAL A N   1 ? 
ATOM   1516 C CA  . VAL A 1 246 ? -26.430 -23.723 -13.372 1.000 31.117 ? 272 VAL A CA  1 ? 
ATOM   1517 C C   . VAL A 1 246 ? -26.306 -24.031 -14.858 1.000 35.179 ? 272 VAL A C   1 ? 
ATOM   1518 O O   . VAL A 1 246 ? -27.336 -24.075 -15.530 1.000 30.509 ? 272 VAL A O   1 ? 
ATOM   1519 C CB  . VAL A 1 246 ? -27.247 -24.792 -12.646 1.000 31.050 ? 272 VAL A CB  1 ? 
ATOM   1520 C CG1 . VAL A 1 246 ? -26.679 -26.173 -12.812 1.000 26.859 ? 272 VAL A CG1 1 ? 
ATOM   1521 C CG2 . VAL A 1 246 ? -27.390 -24.446 -11.173 1.000 36.080 ? 272 VAL A CG2 1 ? 
ATOM   1522 N N   . THR A 1 247 ? -25.090 -24.154 -15.389 1.000 31.100 ? 273 THR A N   1 ? 
ATOM   1523 C CA  . THR A 1 247 ? -24.894 -24.453 -16.833 1.000 34.824 ? 273 THR A CA  1 ? 
ATOM   1524 C C   . THR A 1 247 ? -24.041 -25.720 -17.013 1.000 39.281 ? 273 THR A C   1 ? 
ATOM   1525 O O   . THR A 1 247 ? -22.944 -25.846 -16.419 1.000 33.725 ? 273 THR A O   1 ? 
ATOM   1526 C CB  . THR A 1 247 ? -24.270 -23.267 -17.554 1.000 39.907 ? 273 THR A CB  1 ? 
ATOM   1527 O OG1 . THR A 1 247 ? -22.956 -23.324 -16.979 1.000 45.276 ? 273 THR A OG1 1 ? 
ATOM   1528 C CG2 . THR A 1 247 ? -24.979 -21.949 -17.299 1.000 36.122 ? 273 THR A CG2 1 ? 
ATOM   1529 N N   . ILE A 1 248 ? -24.503 -26.621 -17.862 1.000 33.636 ? 274 ILE A N   1 ? 
ATOM   1530 C CA  . ILE A 1 248 ? -23.764 -27.872 -18.171 1.000 36.239 ? 274 ILE A CA  1 ? 
ATOM   1531 C C   . ILE A 1 248 ? -22.521 -27.486 -18.981 1.000 37.457 ? 274 ILE A C   1 ? 
ATOM   1532 O O   . ILE A 1 248 ? -22.587 -26.539 -19.762 1.000 36.045 ? 274 ILE A O   1 ? 
ATOM   1533 C CB  . ILE A 1 248 ? -24.743 -28.807 -18.877 1.000 39.399 ? 274 ILE A CB  1 ? 
ATOM   1534 C CG1 . ILE A 1 248 ? -24.298 -30.260 -18.859 1.000 39.738 ? 274 ILE A CG1 1 ? 
ATOM   1535 C CG2 . ILE A 1 248 ? -25.090 -28.295 -20.273 1.000 40.779 ? 274 ILE A CG2 1 ? 
ATOM   1536 C CD1 . ILE A 1 248 ? -25.481 -31.178 -19.062 1.000 41.921 ? 274 ILE A CD1 1 ? 
ATOM   1537 N N   . PRO A 1 249 ? -21.322 -28.060 -18.689 1.000 34.687 ? 275 PRO A N   1 ? 
ATOM   1538 C CA  . PRO A 1 249 ? -20.099 -27.745 -19.436 1.000 42.848 ? 275 PRO A CA  1 ? 
ATOM   1539 C C   . PRO A 1 249 ? -20.155 -28.044 -20.949 1.000 46.402 ? 275 PRO A C   1 ? 
ATOM   1540 O O   . PRO A 1 249 ? -20.772 -29.041 -21.291 1.000 48.193 ? 275 PRO A O   1 ? 
ATOM   1541 C CB  . PRO A 1 249 ? -19.089 -28.719 -18.843 1.000 43.902 ? 275 PRO A CB  1 ? 
ATOM   1542 C CG  . PRO A 1 249 ? -19.593 -28.986 -17.475 1.000 45.863 ? 275 PRO A CG  1 ? 
ATOM   1543 C CD  . PRO A 1 249 ? -21.092 -29.046 -17.634 1.000 38.578 ? 275 PRO A CD  1 ? 
ATOM   1544 N N   . GLN A 1 250 ? -19.490 -27.231 -21.791 1.000 51.574 ? 276 GLN A N   1 ? 
ATOM   1545 C CA  . GLN A 1 250 ? -19.450 -27.341 -23.291 1.000 58.361 ? 276 GLN A CA  1 ? 
ATOM   1546 C C   . GLN A 1 250 ? -18.076 -27.802 -23.804 1.000 63.677 ? 276 GLN A C   1 ? 
ATOM   1547 O O   . GLN A 1 250 ? -17.321 -28.467 -23.077 1.000 71.183 ? 276 GLN A O   1 ? 
ATOM   1548 C CB  . GLN A 1 250 ? -19.819 -25.988 -23.889 1.000 56.387 ? 276 GLN A CB  1 ? 
ATOM   1549 C CG  . GLN A 1 250 ? -21.248 -25.624 -23.509 1.000 62.926 ? 276 GLN A CG  1 ? 
ATOM   1550 C CD  . GLN A 1 250 ? -21.604 -24.172 -23.684 1.000 77.736 ? 276 GLN A CD  1 ? 
ATOM   1551 O OE1 . GLN A 1 250 ? -20.732 -23.320 -23.845 1.000 79.379 ? 276 GLN A OE1 1 ? 
ATOM   1552 N NE2 . GLN A 1 250 ? -22.904 -23.895 -23.643 1.000 97.515 ? 276 GLN A NE2 1 ? 
HETATM 1553 O O   . HOH B 2 .   ? 0.327   -30.302 -11.623 1.000 49.066 ? 301 HOH A O   1 ? 
HETATM 1554 O O   . HOH B 2 .   ? -4.091  -23.091 3.741   1.000 40.306 ? 302 HOH A O   1 ? 
HETATM 1555 O O   . HOH B 2 .   ? -37.852 -45.702 -20.323 1.000 48.441 ? 303 HOH A O   1 ? 
HETATM 1556 O O   . HOH B 2 .   ? -29.087 -24.757 -0.697  1.000 45.075 ? 304 HOH A O   1 ? 
HETATM 1557 O O   . HOH B 2 .   ? -13.138 -14.498 0.076   1.000 50.932 ? 305 HOH A O   1 ? 
HETATM 1558 O O   . HOH B 2 .   ? -42.853 -42.954 -7.397  1.000 46.989 ? 306 HOH A O   1 ? 
HETATM 1559 O O   . HOH B 2 .   ? -22.528 -12.622 -1.610  1.000 53.312 ? 307 HOH A O   1 ? 
HETATM 1560 O O   . HOH B 2 .   ? -41.830 -45.266 -11.231 1.000 47.556 ? 308 HOH A O   1 ? 
HETATM 1561 O O   . HOH B 2 .   ? -34.905 -18.671 -14.840 1.000 47.146 ? 309 HOH A O   1 ? 
HETATM 1562 O O   . HOH B 2 .   ? -29.318 -34.233 1.004   1.000 45.145 ? 310 HOH A O   1 ? 
HETATM 1563 O O   . HOH B 2 .   ? 0.911   -40.526 -4.392  1.000 47.453 ? 311 HOH A O   1 ? 
HETATM 1564 O O   . HOH B 2 .   ? -38.574 -25.429 -19.775 1.000 39.746 ? 312 HOH A O   1 ? 
HETATM 1565 O O   . HOH B 2 .   ? -29.342 -41.871 -1.293  1.000 49.839 ? 313 HOH A O   1 ? 
HETATM 1566 O O   . HOH B 2 .   ? 1.533   -27.434 -9.044  1.000 48.680 ? 314 HOH A O   1 ? 
HETATM 1567 O O   . HOH B 2 .   ? -16.426 -42.152 -0.510  1.000 50.164 ? 315 HOH A O   1 ? 
HETATM 1568 O O   . HOH B 2 .   ? -17.428 -33.770 -18.015 1.000 39.512 ? 316 HOH A O   1 ? 
HETATM 1569 O O   . HOH B 2 .   ? -6.163  -31.400 4.608   1.000 52.657 ? 317 HOH A O   1 ? 
HETATM 1570 O O   . HOH B 2 .   ? -20.325 -28.513 2.951   1.000 44.198 ? 318 HOH A O   1 ? 
HETATM 1571 O O   . HOH B 2 .   ? -13.967 -43.207 -15.152 1.000 48.571 ? 319 HOH A O   1 ? 
HETATM 1572 O O   . HOH B 2 .   ? -37.600 -32.236 -2.557  1.000 36.755 ? 320 HOH A O   1 ? 
HETATM 1573 O O   . HOH B 2 .   ? -34.256 -41.651 -2.737  1.000 46.331 ? 321 HOH A O   1 ? 
HETATM 1574 O O   . HOH B 2 .   ? -7.180  -19.733 2.298   1.000 37.609 ? 322 HOH A O   1 ? 
HETATM 1575 O O   . HOH B 2 .   ? -42.710 -29.854 -8.532  1.000 55.278 ? 323 HOH A O   1 ? 
HETATM 1576 O O   . HOH B 2 .   ? -20.986 -40.189 -21.067 1.000 42.063 ? 324 HOH A O   1 ? 
HETATM 1577 O O   . HOH B 2 .   ? -20.471 -43.517 -15.253 1.000 40.888 ? 325 HOH A O   1 ? 
HETATM 1578 O O   . HOH B 2 .   ? -8.732  -29.202 -19.591 1.000 42.585 ? 326 HOH A O   1 ? 
HETATM 1579 O O   . HOH B 2 .   ? -2.465  -19.351 -14.627 1.000 51.761 ? 327 HOH A O   1 ? 
HETATM 1580 O O   . HOH B 2 .   ? -39.210 -30.759 -19.174 1.000 39.536 ? 328 HOH A O   1 ? 
HETATM 1581 O O   . HOH B 2 .   ? -36.456 -44.356 -22.399 1.000 45.271 ? 329 HOH A O   1 ? 
HETATM 1582 O O   . HOH B 2 .   ? -28.408 -21.399 -17.106 1.000 39.295 ? 330 HOH A O   1 ? 
HETATM 1583 O O   . HOH B 2 .   ? -32.926 -22.143 -17.944 1.000 47.699 ? 331 HOH A O   1 ? 
HETATM 1584 O O   . HOH B 2 .   ? -27.139 -35.183 2.494   1.000 37.287 ? 332 HOH A O   1 ? 
HETATM 1585 O O   . HOH B 2 .   ? -4.583  -32.055 -1.862  1.000 35.950 ? 333 HOH A O   1 ? 
HETATM 1586 O O   . HOH B 2 .   ? -19.133 -16.946 2.993   1.000 55.757 ? 334 HOH A O   1 ? 
HETATM 1587 O O   . HOH B 2 .   ? -39.172 -23.057 -7.819  1.000 45.665 ? 335 HOH A O   1 ? 
HETATM 1588 O O   . HOH B 2 .   ? -35.818 -22.614 -21.881 1.000 44.067 ? 336 HOH A O   1 ? 
HETATM 1589 O O   . HOH B 2 .   ? -8.830  -21.804 -20.082 1.000 57.769 ? 337 HOH A O   1 ? 
HETATM 1590 O O   . HOH B 2 .   ? -17.885 -28.054 7.034   1.000 35.269 ? 338 HOH A O   1 ? 
HETATM 1591 O O   . HOH B 2 .   ? -11.632 -40.267 -2.105  1.000 52.237 ? 339 HOH A O   1 ? 
HETATM 1592 O O   . HOH B 2 .   ? -38.286 -38.778 -9.963  1.000 32.828 ? 340 HOH A O   1 ? 
HETATM 1593 O O   . HOH B 2 .   ? -22.540 -38.638 -6.443  1.000 42.792 ? 341 HOH A O   1 ? 
HETATM 1594 O O   . HOH B 2 .   ? -32.259 -16.285 -2.097  1.000 51.907 ? 342 HOH A O   1 ? 
HETATM 1595 O O   . HOH B 2 .   ? -5.579  -40.955 -4.273  1.000 45.093 ? 343 HOH A O   1 ? 
HETATM 1596 O O   . HOH B 2 .   ? -16.278 -43.750 -14.438 1.000 43.041 ? 344 HOH A O   1 ? 
HETATM 1597 O O   . HOH B 2 .   ? -46.916 -33.903 -12.897 1.000 52.790 ? 345 HOH A O   1 ? 
HETATM 1598 O O   . HOH B 2 .   ? -4.345  -40.277 -19.608 1.000 66.059 ? 346 HOH A O   1 ? 
HETATM 1599 O O   . HOH B 2 .   ? -29.538 -15.125 -9.512  1.000 51.759 ? 347 HOH A O   1 ? 
HETATM 1600 O O   . HOH B 2 .   ? -21.358 -30.605 -23.485 1.000 47.715 ? 348 HOH A O   1 ? 
HETATM 1601 O O   . HOH B 2 .   ? -25.928 -44.375 -6.642  1.000 53.220 ? 349 HOH A O   1 ? 
HETATM 1602 O O   . HOH B 2 .   ? -45.049 -32.871 -19.536 1.000 57.154 ? 350 HOH A O   1 ? 
HETATM 1603 O O   . HOH B 2 .   ? -19.881 -21.878 2.027   1.000 47.362 ? 351 HOH A O   1 ? 
HETATM 1604 O O   . HOH B 2 .   ? 2.771   -33.202 -7.332  1.000 38.357 ? 352 HOH A O   1 ? 
HETATM 1605 O O   . HOH B 2 .   ? -0.913  -27.512 -8.067  1.000 42.485 ? 353 HOH A O   1 ? 
HETATM 1606 O O   . HOH B 2 .   ? -40.517 -42.550 -21.132 1.000 56.519 ? 354 HOH A O   1 ? 
HETATM 1607 O O   . HOH B 2 .   ? -20.745 -21.481 -6.819  1.000 36.831 ? 355 HOH A O   1 ? 
HETATM 1608 O O   . HOH B 2 .   ? -28.623 -31.615 -21.115 1.000 49.411 ? 356 HOH A O   1 ? 
HETATM 1609 O O   . HOH B 2 .   ? -29.948 -46.360 -10.110 1.000 55.762 ? 357 HOH A O   1 ? 
HETATM 1610 O O   . HOH B 2 .   ? -14.718 -21.609 2.542   1.000 30.204 ? 358 HOH A O   1 ? 
HETATM 1611 O O   . HOH B 2 .   ? -5.737  -18.324 -19.930 1.000 59.263 ? 359 HOH A O   1 ? 
HETATM 1612 O O   . HOH B 2 .   ? -5.654  -42.081 -14.824 1.000 51.805 ? 360 HOH A O   1 ? 
HETATM 1613 O O   . HOH B 2 .   ? -18.254 -25.025 -20.390 1.000 40.670 ? 361 HOH A O   1 ? 
HETATM 1614 O O   . HOH B 2 .   ? -7.856  -16.633 -8.869  1.000 47.802 ? 362 HOH A O   1 ? 
HETATM 1615 O O   . HOH B 2 .   ? 0.335   -24.515 -3.739  1.000 49.882 ? 363 HOH A O   1 ? 
HETATM 1616 O O   . HOH B 2 .   ? -17.310 -42.124 2.856   1.000 50.669 ? 364 HOH A O   1 ? 
HETATM 1617 O O   . HOH B 2 .   ? -11.296 -13.814 -3.207  1.000 47.658 ? 365 HOH A O   1 ? 
HETATM 1618 O O   . HOH B 2 .   ? -15.019 -24.823 -19.793 1.000 32.314 ? 366 HOH A O   1 ? 
HETATM 1619 O O   . HOH B 2 .   ? -3.918  -34.117 -16.064 1.000 51.079 ? 367 HOH A O   1 ? 
HETATM 1620 O O   . HOH B 2 .   ? -12.522 -18.432 -16.144 1.000 44.508 ? 368 HOH A O   1 ? 
HETATM 1621 O O   . HOH B 2 .   ? -16.165 -27.391 -20.481 1.000 46.026 ? 369 HOH A O   1 ? 
HETATM 1622 O O   . HOH B 2 .   ? -40.739 -41.677 -3.579  1.000 38.944 ? 370 HOH A O   1 ? 
HETATM 1623 O O   . HOH B 2 .   ? -33.393 -25.083 -1.762  1.000 47.383 ? 371 HOH A O   1 ? 
HETATM 1624 O O   . HOH B 2 .   ? -2.653  -44.557 -3.246  1.000 45.889 ? 372 HOH A O   1 ? 
HETATM 1625 O O   . HOH B 2 .   ? -5.761  -45.202 -10.178 1.000 40.924 ? 373 HOH A O   1 ? 
HETATM 1626 O O   . HOH B 2 .   ? -12.296 -31.995 8.572   1.000 55.835 ? 374 HOH A O   1 ? 
HETATM 1627 O O   . HOH B 2 .   ? -32.904 -46.372 -20.433 1.000 46.281 ? 375 HOH A O   1 ? 
HETATM 1628 O O   . HOH B 2 .   ? -23.337 -17.771 1.793   1.000 38.408 ? 376 HOH A O   1 ? 
HETATM 1629 O O   . HOH B 2 .   ? -0.363  -21.693 -6.050  1.000 40.170 ? 377 HOH A O   1 ? 
HETATM 1630 O O   . HOH B 2 .   ? -29.472 -20.398 3.662   1.000 25.127 ? 378 HOH A O   1 ? 
HETATM 1631 O O   . HOH B 2 .   ? -4.754  -25.858 -24.644 1.000 49.523 ? 379 HOH A O   1 ? 
HETATM 1632 O O   . HOH B 2 .   ? -18.678 -38.610 -19.645 1.000 26.811 ? 380 HOH A O   1 ? 
HETATM 1633 O O   . HOH B 2 .   ? -20.034 -45.344 -20.121 1.000 62.921 ? 381 HOH A O   1 ? 
HETATM 1634 O O   . HOH B 2 .   ? -26.396 -32.103 2.418   1.000 46.148 ? 382 HOH A O   1 ? 
HETATM 1635 O O   . HOH B 2 .   ? -41.321 -44.778 -17.376 1.000 29.744 ? 383 HOH A O   1 ? 
HETATM 1636 O O   . HOH B 2 .   ? -44.369 -38.336 -19.919 1.000 32.567 ? 384 HOH A O   1 ? 
HETATM 1637 O O   . HOH B 2 .   ? -20.111 -42.802 -21.998 1.000 51.147 ? 385 HOH A O   1 ? 
HETATM 1638 O O   . HOH B 2 .   ? -29.066 -31.822 1.176   1.000 40.293 ? 386 HOH A O   1 ? 
HETATM 1639 O O   . HOH B 2 .   ? -9.094  -40.364 -20.755 1.000 44.984 ? 387 HOH A O   1 ? 
HETATM 1640 O O   . HOH B 2 .   ? -13.670 -40.341 0.284   1.000 32.725 ? 388 HOH A O   1 ? 
HETATM 1641 O O   . HOH B 2 .   ? -13.185 -27.414 8.284   1.000 53.112 ? 389 HOH A O   1 ? 
HETATM 1642 O O   . HOH B 2 .   ? -25.714 -41.762 -23.653 1.000 41.303 ? 390 HOH A O   1 ? 
HETATM 1643 O O   . HOH B 2 .   ? -30.613 -44.939 -20.327 1.000 48.034 ? 391 HOH A O   1 ? 
HETATM 1644 O O   . HOH B 2 .   ? -4.677  -30.934 6.693   1.000 46.307 ? 392 HOH A O   1 ? 
HETATM 1645 O O   . HOH B 2 .   ? -20.572 -45.757 -17.076 1.000 50.297 ? 393 HOH A O   1 ? 
HETATM 1646 O O   . HOH B 2 .   ? -1.833  -35.461 -14.733 1.000 48.035 ? 394 HOH A O   1 ? 
HETATM 1647 O O   . HOH B 2 .   ? -32.180 -45.927 -8.495  1.000 46.824 ? 395 HOH A O   1 ? 
HETATM 1648 O O   . HOH B 2 .   ? 1.642   -30.424 -14.212 1.000 57.617 ? 396 HOH A O   1 ? 
HETATM 1649 O O   . HOH B 2 .   ? -22.160 -20.201 2.682   1.000 53.591 ? 397 HOH A O   1 ? 
HETATM 1650 O O   . HOH B 2 .   ? -3.936  -29.680 9.213   1.000 52.351 ? 398 HOH A O   1 ? 
HETATM 1651 O O   . HOH B 2 .   ? -16.446 -46.254 -15.814 1.000 49.320 ? 399 HOH A O   1 ? 
HETATM 1652 O O   . HOH B 2 .   ? -43.243 -43.243 -22.294 0.500 50.050 ? 400 HOH A O   1 ? 
HETATM 1653 O O   . HOH B 2 .   ? -41.562 -45.323 -8.451  1.000 52.685 ? 401 HOH A O   1 ? 
HETATM 1654 O O   . HOH B 2 .   ? -2.961  -40.854 -0.163  1.000 50.809 ? 402 HOH A O   1 ? 
HETATM 1655 O O   . HOH B 2 .   ? -34.515 -11.589 -9.167  1.000 65.284 ? 403 HOH A O   1 ? 
# 
