data_8X1B
# 
_entry.id   8X1B 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8X1B         pdb_00008x1b 10.2210/pdb8x1b/pdb 
WWPDB D_1300041964 ?            ?                   
EMDB  EMD-37989    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-13 
2 'Structure model' 1 1 2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Data collection' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            em_admin 
# 
_pdbx_audit_revision_item.ordinal             1 
_pdbx_audit_revision_item.revision_ordinal    2 
_pdbx_audit_revision_item.data_content_type   'Structure model' 
_pdbx_audit_revision_item.item                '_em_admin.last_update' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8X1B 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-06 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of FpGalactosaminidase from Flavonifractor plautii in apo state' 
_pdbx_database_related.db_id          EMD-37989 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              101013216@seu.edu.cn 
_pdbx_contact_author.name_first         Pengcheng 
_pdbx_contact_author.name_last          Han 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-4551-6209 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Guoqiu, W.'    1 0000-0002-8859-8654 
'Pengcheng, H.' 2 0000-0002-4551-6209 
'Chao, S.'      3 0000-0002-5824-7968 
'Meiling, Z.'   4 0009-0004-8496-3185 
'Kaishan, L.'   5 0009-0000-1735-0216 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM structure of FpGalactosaminidase from Flavonifractor plautii in apo state' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Pengcheng, H.' 1 0009-0000-1735-0216 
primary 'Kaishan, L.'   2 0000-0002-4551-6209 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           Alpha-galactosidase 
_entity.formula_weight             72515.055 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              P566L 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        FpGalactosaminidase 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;YAIAGNGVRVTYDADGQTITLYRTEGSGLIQMSKPSPLGGPVVGGQEVQDFSHISCDVEQSTSGVMGSGQRMTITSQSMS
TGLIRTYVLETSDIEEGVVYTATSYEAGASDVEVSWFIGSVYELYGAEDRIWSYNGGGEGPMHYYDTLQKIDLTDSGKFS
RENKQDDTAASIPVSDIYIADGGITVGDASATRREVHTPVQETSDSAQVSIGWPGKVIAAGSVIEIGESFAVVHPGDYYN
GLRGYKNAMDHLGVIMPAPGDIPDSSYDLRWESWGWGFNWTIDLIIGKLDELQAAGVKQITLDDGWYTNAGDWALNPEKF
PNGASDALRLTDAIHEHGMTALLWWRPCDGGIDSILYQQHPEYFVMDADGRPARLPTPGGGTNPSLGYALCPMADGAIAS
QVDFVNRAMNDWGFDGFKGDYVWSMPECYNPAHNHASPEESTEKQSEIYRVSYEAMVANDPNVFNLLCNCGTPQDYYSLP
YMTQIATADPTSVDQTRRRVKAYKALMGDYFPVTADHNNIWYLSAVGTGSVLIEKRDLSGTAKEEYEKWLGIADTVQLQK
GRFIGDLYSYGFDPYETYVVEKDGVMYYAFYKDGSKYSPTGYPDIELKGLDPNKMYRIVDYVNDRVVATNLMGDNAVFNT
RFSDYLLVKAVEISEPDP
;
_entity_poly.pdbx_seq_one_letter_code_can   
;YAIAGNGVRVTYDADGQTITLYRTEGSGLIQMSKPSPLGGPVVGGQEVQDFSHISCDVEQSTSGVMGSGQRMTITSQSMS
TGLIRTYVLETSDIEEGVVYTATSYEAGASDVEVSWFIGSVYELYGAEDRIWSYNGGGEGPMHYYDTLQKIDLTDSGKFS
RENKQDDTAASIPVSDIYIADGGITVGDASATRREVHTPVQETSDSAQVSIGWPGKVIAAGSVIEIGESFAVVHPGDYYN
GLRGYKNAMDHLGVIMPAPGDIPDSSYDLRWESWGWGFNWTIDLIIGKLDELQAAGVKQITLDDGWYTNAGDWALNPEKF
PNGASDALRLTDAIHEHGMTALLWWRPCDGGIDSILYQQHPEYFVMDADGRPARLPTPGGGTNPSLGYALCPMADGAIAS
QVDFVNRAMNDWGFDGFKGDYVWSMPECYNPAHNHASPEESTEKQSEIYRVSYEAMVANDPNVFNLLCNCGTPQDYYSLP
YMTQIATADPTSVDQTRRRVKAYKALMGDYFPVTADHNNIWYLSAVGTGSVLIEKRDLSGTAKEEYEKWLGIADTVQLQK
GRFIGDLYSYGFDPYETYVVEKDGVMYYAFYKDGSKYSPTGYPDIELKGLDPNKMYRIVDYVNDRVVATNLMGDNAVFNT
RFSDYLLVKAVEISEPDP
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   TYR n 
1 2   ALA n 
1 3   ILE n 
1 4   ALA n 
1 5   GLY n 
1 6   ASN n 
1 7   GLY n 
1 8   VAL n 
1 9   ARG n 
1 10  VAL n 
1 11  THR n 
1 12  TYR n 
1 13  ASP n 
1 14  ALA n 
1 15  ASP n 
1 16  GLY n 
1 17  GLN n 
1 18  THR n 
1 19  ILE n 
1 20  THR n 
1 21  LEU n 
1 22  TYR n 
1 23  ARG n 
1 24  THR n 
1 25  GLU n 
1 26  GLY n 
1 27  SER n 
1 28  GLY n 
1 29  LEU n 
1 30  ILE n 
1 31  GLN n 
1 32  MET n 
1 33  SER n 
1 34  LYS n 
1 35  PRO n 
1 36  SER n 
1 37  PRO n 
1 38  LEU n 
1 39  GLY n 
1 40  GLY n 
1 41  PRO n 
1 42  VAL n 
1 43  VAL n 
1 44  GLY n 
1 45  GLY n 
1 46  GLN n 
1 47  GLU n 
1 48  VAL n 
1 49  GLN n 
1 50  ASP n 
1 51  PHE n 
1 52  SER n 
1 53  HIS n 
1 54  ILE n 
1 55  SER n 
1 56  CYS n 
1 57  ASP n 
1 58  VAL n 
1 59  GLU n 
1 60  GLN n 
1 61  SER n 
1 62  THR n 
1 63  SER n 
1 64  GLY n 
1 65  VAL n 
1 66  MET n 
1 67  GLY n 
1 68  SER n 
1 69  GLY n 
1 70  GLN n 
1 71  ARG n 
1 72  MET n 
1 73  THR n 
1 74  ILE n 
1 75  THR n 
1 76  SER n 
1 77  GLN n 
1 78  SER n 
1 79  MET n 
1 80  SER n 
1 81  THR n 
1 82  GLY n 
1 83  LEU n 
1 84  ILE n 
1 85  ARG n 
1 86  THR n 
1 87  TYR n 
1 88  VAL n 
1 89  LEU n 
1 90  GLU n 
1 91  THR n 
1 92  SER n 
1 93  ASP n 
1 94  ILE n 
1 95  GLU n 
1 96  GLU n 
1 97  GLY n 
1 98  VAL n 
1 99  VAL n 
1 100 TYR n 
1 101 THR n 
1 102 ALA n 
1 103 THR n 
1 104 SER n 
1 105 TYR n 
1 106 GLU n 
1 107 ALA n 
1 108 GLY n 
1 109 ALA n 
1 110 SER n 
1 111 ASP n 
1 112 VAL n 
1 113 GLU n 
1 114 VAL n 
1 115 SER n 
1 116 TRP n 
1 117 PHE n 
1 118 ILE n 
1 119 GLY n 
1 120 SER n 
1 121 VAL n 
1 122 TYR n 
1 123 GLU n 
1 124 LEU n 
1 125 TYR n 
1 126 GLY n 
1 127 ALA n 
1 128 GLU n 
1 129 ASP n 
1 130 ARG n 
1 131 ILE n 
1 132 TRP n 
1 133 SER n 
1 134 TYR n 
1 135 ASN n 
1 136 GLY n 
1 137 GLY n 
1 138 GLY n 
1 139 GLU n 
1 140 GLY n 
1 141 PRO n 
1 142 MET n 
1 143 HIS n 
1 144 TYR n 
1 145 TYR n 
1 146 ASP n 
1 147 THR n 
1 148 LEU n 
1 149 GLN n 
1 150 LYS n 
1 151 ILE n 
1 152 ASP n 
1 153 LEU n 
1 154 THR n 
1 155 ASP n 
1 156 SER n 
1 157 GLY n 
1 158 LYS n 
1 159 PHE n 
1 160 SER n 
1 161 ARG n 
1 162 GLU n 
1 163 ASN n 
1 164 LYS n 
1 165 GLN n 
1 166 ASP n 
1 167 ASP n 
1 168 THR n 
1 169 ALA n 
1 170 ALA n 
1 171 SER n 
1 172 ILE n 
1 173 PRO n 
1 174 VAL n 
1 175 SER n 
1 176 ASP n 
1 177 ILE n 
1 178 TYR n 
1 179 ILE n 
1 180 ALA n 
1 181 ASP n 
1 182 GLY n 
1 183 GLY n 
1 184 ILE n 
1 185 THR n 
1 186 VAL n 
1 187 GLY n 
1 188 ASP n 
1 189 ALA n 
1 190 SER n 
1 191 ALA n 
1 192 THR n 
1 193 ARG n 
1 194 ARG n 
1 195 GLU n 
1 196 VAL n 
1 197 HIS n 
1 198 THR n 
1 199 PRO n 
1 200 VAL n 
1 201 GLN n 
1 202 GLU n 
1 203 THR n 
1 204 SER n 
1 205 ASP n 
1 206 SER n 
1 207 ALA n 
1 208 GLN n 
1 209 VAL n 
1 210 SER n 
1 211 ILE n 
1 212 GLY n 
1 213 TRP n 
1 214 PRO n 
1 215 GLY n 
1 216 LYS n 
1 217 VAL n 
1 218 ILE n 
1 219 ALA n 
1 220 ALA n 
1 221 GLY n 
1 222 SER n 
1 223 VAL n 
1 224 ILE n 
1 225 GLU n 
1 226 ILE n 
1 227 GLY n 
1 228 GLU n 
1 229 SER n 
1 230 PHE n 
1 231 ALA n 
1 232 VAL n 
1 233 VAL n 
1 234 HIS n 
1 235 PRO n 
1 236 GLY n 
1 237 ASP n 
1 238 TYR n 
1 239 TYR n 
1 240 ASN n 
1 241 GLY n 
1 242 LEU n 
1 243 ARG n 
1 244 GLY n 
1 245 TYR n 
1 246 LYS n 
1 247 ASN n 
1 248 ALA n 
1 249 MET n 
1 250 ASP n 
1 251 HIS n 
1 252 LEU n 
1 253 GLY n 
1 254 VAL n 
1 255 ILE n 
1 256 MET n 
1 257 PRO n 
1 258 ALA n 
1 259 PRO n 
1 260 GLY n 
1 261 ASP n 
1 262 ILE n 
1 263 PRO n 
1 264 ASP n 
1 265 SER n 
1 266 SER n 
1 267 TYR n 
1 268 ASP n 
1 269 LEU n 
1 270 ARG n 
1 271 TRP n 
1 272 GLU n 
1 273 SER n 
1 274 TRP n 
1 275 GLY n 
1 276 TRP n 
1 277 GLY n 
1 278 PHE n 
1 279 ASN n 
1 280 TRP n 
1 281 THR n 
1 282 ILE n 
1 283 ASP n 
1 284 LEU n 
1 285 ILE n 
1 286 ILE n 
1 287 GLY n 
1 288 LYS n 
1 289 LEU n 
1 290 ASP n 
1 291 GLU n 
1 292 LEU n 
1 293 GLN n 
1 294 ALA n 
1 295 ALA n 
1 296 GLY n 
1 297 VAL n 
1 298 LYS n 
1 299 GLN n 
1 300 ILE n 
1 301 THR n 
1 302 LEU n 
1 303 ASP n 
1 304 ASP n 
1 305 GLY n 
1 306 TRP n 
1 307 TYR n 
1 308 THR n 
1 309 ASN n 
1 310 ALA n 
1 311 GLY n 
1 312 ASP n 
1 313 TRP n 
1 314 ALA n 
1 315 LEU n 
1 316 ASN n 
1 317 PRO n 
1 318 GLU n 
1 319 LYS n 
1 320 PHE n 
1 321 PRO n 
1 322 ASN n 
1 323 GLY n 
1 324 ALA n 
1 325 SER n 
1 326 ASP n 
1 327 ALA n 
1 328 LEU n 
1 329 ARG n 
1 330 LEU n 
1 331 THR n 
1 332 ASP n 
1 333 ALA n 
1 334 ILE n 
1 335 HIS n 
1 336 GLU n 
1 337 HIS n 
1 338 GLY n 
1 339 MET n 
1 340 THR n 
1 341 ALA n 
1 342 LEU n 
1 343 LEU n 
1 344 TRP n 
1 345 TRP n 
1 346 ARG n 
1 347 PRO n 
1 348 CYS n 
1 349 ASP n 
1 350 GLY n 
1 351 GLY n 
1 352 ILE n 
1 353 ASP n 
1 354 SER n 
1 355 ILE n 
1 356 LEU n 
1 357 TYR n 
1 358 GLN n 
1 359 GLN n 
1 360 HIS n 
1 361 PRO n 
1 362 GLU n 
1 363 TYR n 
1 364 PHE n 
1 365 VAL n 
1 366 MET n 
1 367 ASP n 
1 368 ALA n 
1 369 ASP n 
1 370 GLY n 
1 371 ARG n 
1 372 PRO n 
1 373 ALA n 
1 374 ARG n 
1 375 LEU n 
1 376 PRO n 
1 377 THR n 
1 378 PRO n 
1 379 GLY n 
1 380 GLY n 
1 381 GLY n 
1 382 THR n 
1 383 ASN n 
1 384 PRO n 
1 385 SER n 
1 386 LEU n 
1 387 GLY n 
1 388 TYR n 
1 389 ALA n 
1 390 LEU n 
1 391 CYS n 
1 392 PRO n 
1 393 MET n 
1 394 ALA n 
1 395 ASP n 
1 396 GLY n 
1 397 ALA n 
1 398 ILE n 
1 399 ALA n 
1 400 SER n 
1 401 GLN n 
1 402 VAL n 
1 403 ASP n 
1 404 PHE n 
1 405 VAL n 
1 406 ASN n 
1 407 ARG n 
1 408 ALA n 
1 409 MET n 
1 410 ASN n 
1 411 ASP n 
1 412 TRP n 
1 413 GLY n 
1 414 PHE n 
1 415 ASP n 
1 416 GLY n 
1 417 PHE n 
1 418 LYS n 
1 419 GLY n 
1 420 ASP n 
1 421 TYR n 
1 422 VAL n 
1 423 TRP n 
1 424 SER n 
1 425 MET n 
1 426 PRO n 
1 427 GLU n 
1 428 CYS n 
1 429 TYR n 
1 430 ASN n 
1 431 PRO n 
1 432 ALA n 
1 433 HIS n 
1 434 ASN n 
1 435 HIS n 
1 436 ALA n 
1 437 SER n 
1 438 PRO n 
1 439 GLU n 
1 440 GLU n 
1 441 SER n 
1 442 THR n 
1 443 GLU n 
1 444 LYS n 
1 445 GLN n 
1 446 SER n 
1 447 GLU n 
1 448 ILE n 
1 449 TYR n 
1 450 ARG n 
1 451 VAL n 
1 452 SER n 
1 453 TYR n 
1 454 GLU n 
1 455 ALA n 
1 456 MET n 
1 457 VAL n 
1 458 ALA n 
1 459 ASN n 
1 460 ASP n 
1 461 PRO n 
1 462 ASN n 
1 463 VAL n 
1 464 PHE n 
1 465 ASN n 
1 466 LEU n 
1 467 LEU n 
1 468 CYS n 
1 469 ASN n 
1 470 CYS n 
1 471 GLY n 
1 472 THR n 
1 473 PRO n 
1 474 GLN n 
1 475 ASP n 
1 476 TYR n 
1 477 TYR n 
1 478 SER n 
1 479 LEU n 
1 480 PRO n 
1 481 TYR n 
1 482 MET n 
1 483 THR n 
1 484 GLN n 
1 485 ILE n 
1 486 ALA n 
1 487 THR n 
1 488 ALA n 
1 489 ASP n 
1 490 PRO n 
1 491 THR n 
1 492 SER n 
1 493 VAL n 
1 494 ASP n 
1 495 GLN n 
1 496 THR n 
1 497 ARG n 
1 498 ARG n 
1 499 ARG n 
1 500 VAL n 
1 501 LYS n 
1 502 ALA n 
1 503 TYR n 
1 504 LYS n 
1 505 ALA n 
1 506 LEU n 
1 507 MET n 
1 508 GLY n 
1 509 ASP n 
1 510 TYR n 
1 511 PHE n 
1 512 PRO n 
1 513 VAL n 
1 514 THR n 
1 515 ALA n 
1 516 ASP n 
1 517 HIS n 
1 518 ASN n 
1 519 ASN n 
1 520 ILE n 
1 521 TRP n 
1 522 TYR n 
1 523 LEU n 
1 524 SER n 
1 525 ALA n 
1 526 VAL n 
1 527 GLY n 
1 528 THR n 
1 529 GLY n 
1 530 SER n 
1 531 VAL n 
1 532 LEU n 
1 533 ILE n 
1 534 GLU n 
1 535 LYS n 
1 536 ARG n 
1 537 ASP n 
1 538 LEU n 
1 539 SER n 
1 540 GLY n 
1 541 THR n 
1 542 ALA n 
1 543 LYS n 
1 544 GLU n 
1 545 GLU n 
1 546 TYR n 
1 547 GLU n 
1 548 LYS n 
1 549 TRP n 
1 550 LEU n 
1 551 GLY n 
1 552 ILE n 
1 553 ALA n 
1 554 ASP n 
1 555 THR n 
1 556 VAL n 
1 557 GLN n 
1 558 LEU n 
1 559 GLN n 
1 560 LYS n 
1 561 GLY n 
1 562 ARG n 
1 563 PHE n 
1 564 ILE n 
1 565 GLY n 
1 566 ASP n 
1 567 LEU n 
1 568 TYR n 
1 569 SER n 
1 570 TYR n 
1 571 GLY n 
1 572 PHE n 
1 573 ASP n 
1 574 PRO n 
1 575 TYR n 
1 576 GLU n 
1 577 THR n 
1 578 TYR n 
1 579 VAL n 
1 580 VAL n 
1 581 GLU n 
1 582 LYS n 
1 583 ASP n 
1 584 GLY n 
1 585 VAL n 
1 586 MET n 
1 587 TYR n 
1 588 TYR n 
1 589 ALA n 
1 590 PHE n 
1 591 TYR n 
1 592 LYS n 
1 593 ASP n 
1 594 GLY n 
1 595 SER n 
1 596 LYS n 
1 597 TYR n 
1 598 SER n 
1 599 PRO n 
1 600 THR n 
1 601 GLY n 
1 602 TYR n 
1 603 PRO n 
1 604 ASP n 
1 605 ILE n 
1 606 GLU n 
1 607 LEU n 
1 608 LYS n 
1 609 GLY n 
1 610 LEU n 
1 611 ASP n 
1 612 PRO n 
1 613 ASN n 
1 614 LYS n 
1 615 MET n 
1 616 TYR n 
1 617 ARG n 
1 618 ILE n 
1 619 VAL n 
1 620 ASP n 
1 621 TYR n 
1 622 VAL n 
1 623 ASN n 
1 624 ASP n 
1 625 ARG n 
1 626 VAL n 
1 627 VAL n 
1 628 ALA n 
1 629 THR n 
1 630 ASN n 
1 631 LEU n 
1 632 MET n 
1 633 GLY n 
1 634 ASP n 
1 635 ASN n 
1 636 ALA n 
1 637 VAL n 
1 638 PHE n 
1 639 ASN n 
1 640 THR n 
1 641 ARG n 
1 642 PHE n 
1 643 SER n 
1 644 ASP n 
1 645 TYR n 
1 646 LEU n 
1 647 LEU n 
1 648 VAL n 
1 649 LYS n 
1 650 ALA n 
1 651 VAL n 
1 652 GLU n 
1 653 ILE n 
1 654 SER n 
1 655 GLU n 
1 656 PRO n 
1 657 ASP n 
1 658 PRO n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   658 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ERS852411_00574 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Flavonifractor plautii' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     292800 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   TYR 1   44  44  TYR TYR A . n 
A 1 2   ALA 2   45  45  ALA ALA A . n 
A 1 3   ILE 3   46  46  ILE ILE A . n 
A 1 4   ALA 4   47  47  ALA ALA A . n 
A 1 5   GLY 5   48  48  GLY GLY A . n 
A 1 6   ASN 6   49  49  ASN ASN A . n 
A 1 7   GLY 7   50  50  GLY GLY A . n 
A 1 8   VAL 8   51  51  VAL VAL A . n 
A 1 9   ARG 9   52  52  ARG ARG A . n 
A 1 10  VAL 10  53  53  VAL VAL A . n 
A 1 11  THR 11  54  54  THR THR A . n 
A 1 12  TYR 12  55  55  TYR TYR A . n 
A 1 13  ASP 13  56  56  ASP ASP A . n 
A 1 14  ALA 14  57  57  ALA ALA A . n 
A 1 15  ASP 15  58  58  ASP ASP A . n 
A 1 16  GLY 16  59  59  GLY GLY A . n 
A 1 17  GLN 17  60  60  GLN GLN A . n 
A 1 18  THR 18  61  61  THR THR A . n 
A 1 19  ILE 19  62  62  ILE ILE A . n 
A 1 20  THR 20  63  63  THR THR A . n 
A 1 21  LEU 21  64  64  LEU LEU A . n 
A 1 22  TYR 22  65  65  TYR TYR A . n 
A 1 23  ARG 23  66  66  ARG ARG A . n 
A 1 24  THR 24  67  67  THR THR A . n 
A 1 25  GLU 25  68  68  GLU GLU A . n 
A 1 26  GLY 26  69  69  GLY GLY A . n 
A 1 27  SER 27  70  70  SER SER A . n 
A 1 28  GLY 28  71  71  GLY GLY A . n 
A 1 29  LEU 29  72  72  LEU LEU A . n 
A 1 30  ILE 30  73  73  ILE ILE A . n 
A 1 31  GLN 31  74  74  GLN GLN A . n 
A 1 32  MET 32  75  75  MET MET A . n 
A 1 33  SER 33  76  76  SER SER A . n 
A 1 34  LYS 34  77  77  LYS LYS A . n 
A 1 35  PRO 35  78  78  PRO PRO A . n 
A 1 36  SER 36  79  79  SER SER A . n 
A 1 37  PRO 37  80  80  PRO PRO A . n 
A 1 38  LEU 38  81  81  LEU LEU A . n 
A 1 39  GLY 39  82  82  GLY GLY A . n 
A 1 40  GLY 40  83  83  GLY GLY A . n 
A 1 41  PRO 41  84  84  PRO PRO A . n 
A 1 42  VAL 42  85  85  VAL VAL A . n 
A 1 43  VAL 43  86  86  VAL VAL A . n 
A 1 44  GLY 44  87  87  GLY GLY A . n 
A 1 45  GLY 45  88  88  GLY GLY A . n 
A 1 46  GLN 46  89  89  GLN GLN A . n 
A 1 47  GLU 47  90  90  GLU GLU A . n 
A 1 48  VAL 48  91  91  VAL VAL A . n 
A 1 49  GLN 49  92  92  GLN GLN A . n 
A 1 50  ASP 50  93  93  ASP ASP A . n 
A 1 51  PHE 51  94  94  PHE PHE A . n 
A 1 52  SER 52  95  95  SER SER A . n 
A 1 53  HIS 53  96  96  HIS HIS A . n 
A 1 54  ILE 54  97  97  ILE ILE A . n 
A 1 55  SER 55  98  98  SER SER A . n 
A 1 56  CYS 56  99  99  CYS CYS A . n 
A 1 57  ASP 57  100 100 ASP ASP A . n 
A 1 58  VAL 58  101 101 VAL VAL A . n 
A 1 59  GLU 59  102 102 GLU GLU A . n 
A 1 60  GLN 60  103 103 GLN GLN A . n 
A 1 61  SER 61  104 104 SER SER A . n 
A 1 62  THR 62  105 105 THR THR A . n 
A 1 63  SER 63  106 106 SER SER A . n 
A 1 64  GLY 64  107 107 GLY GLY A . n 
A 1 65  VAL 65  108 108 VAL VAL A . n 
A 1 66  MET 66  109 109 MET MET A . n 
A 1 67  GLY 67  110 110 GLY GLY A . n 
A 1 68  SER 68  111 111 SER SER A . n 
A 1 69  GLY 69  112 112 GLY GLY A . n 
A 1 70  GLN 70  113 113 GLN GLN A . n 
A 1 71  ARG 71  114 114 ARG ARG A . n 
A 1 72  MET 72  115 115 MET MET A . n 
A 1 73  THR 73  116 116 THR THR A . n 
A 1 74  ILE 74  117 117 ILE ILE A . n 
A 1 75  THR 75  118 118 THR THR A . n 
A 1 76  SER 76  119 119 SER SER A . n 
A 1 77  GLN 77  120 120 GLN GLN A . n 
A 1 78  SER 78  121 121 SER SER A . n 
A 1 79  MET 79  122 122 MET MET A . n 
A 1 80  SER 80  123 123 SER SER A . n 
A 1 81  THR 81  124 124 THR THR A . n 
A 1 82  GLY 82  125 125 GLY GLY A . n 
A 1 83  LEU 83  126 126 LEU LEU A . n 
A 1 84  ILE 84  127 127 ILE ILE A . n 
A 1 85  ARG 85  128 128 ARG ARG A . n 
A 1 86  THR 86  129 129 THR THR A . n 
A 1 87  TYR 87  130 130 TYR TYR A . n 
A 1 88  VAL 88  131 131 VAL VAL A . n 
A 1 89  LEU 89  132 132 LEU LEU A . n 
A 1 90  GLU 90  133 133 GLU GLU A . n 
A 1 91  THR 91  134 134 THR THR A . n 
A 1 92  SER 92  135 135 SER SER A . n 
A 1 93  ASP 93  136 136 ASP ASP A . n 
A 1 94  ILE 94  137 137 ILE ILE A . n 
A 1 95  GLU 95  138 138 GLU GLU A . n 
A 1 96  GLU 96  139 139 GLU GLU A . n 
A 1 97  GLY 97  140 140 GLY GLY A . n 
A 1 98  VAL 98  141 141 VAL VAL A . n 
A 1 99  VAL 99  142 142 VAL VAL A . n 
A 1 100 TYR 100 143 143 TYR TYR A . n 
A 1 101 THR 101 144 144 THR THR A . n 
A 1 102 ALA 102 145 145 ALA ALA A . n 
A 1 103 THR 103 146 146 THR THR A . n 
A 1 104 SER 104 147 147 SER SER A . n 
A 1 105 TYR 105 148 148 TYR TYR A . n 
A 1 106 GLU 106 149 149 GLU GLU A . n 
A 1 107 ALA 107 150 150 ALA ALA A . n 
A 1 108 GLY 108 151 151 GLY GLY A . n 
A 1 109 ALA 109 152 152 ALA ALA A . n 
A 1 110 SER 110 153 153 SER SER A . n 
A 1 111 ASP 111 154 154 ASP ASP A . n 
A 1 112 VAL 112 155 155 VAL VAL A . n 
A 1 113 GLU 113 156 156 GLU GLU A . n 
A 1 114 VAL 114 157 157 VAL VAL A . n 
A 1 115 SER 115 158 158 SER SER A . n 
A 1 116 TRP 116 159 159 TRP TRP A . n 
A 1 117 PHE 117 160 160 PHE PHE A . n 
A 1 118 ILE 118 161 161 ILE ILE A . n 
A 1 119 GLY 119 162 162 GLY GLY A . n 
A 1 120 SER 120 163 163 SER SER A . n 
A 1 121 VAL 121 164 164 VAL VAL A . n 
A 1 122 TYR 122 165 165 TYR TYR A . n 
A 1 123 GLU 123 166 166 GLU GLU A . n 
A 1 124 LEU 124 167 167 LEU LEU A . n 
A 1 125 TYR 125 168 168 TYR TYR A . n 
A 1 126 GLY 126 169 169 GLY GLY A . n 
A 1 127 ALA 127 170 170 ALA ALA A . n 
A 1 128 GLU 128 171 171 GLU GLU A . n 
A 1 129 ASP 129 172 172 ASP ASP A . n 
A 1 130 ARG 130 173 173 ARG ARG A . n 
A 1 131 ILE 131 174 174 ILE ILE A . n 
A 1 132 TRP 132 175 175 TRP TRP A . n 
A 1 133 SER 133 176 176 SER SER A . n 
A 1 134 TYR 134 177 177 TYR TYR A . n 
A 1 135 ASN 135 178 178 ASN ASN A . n 
A 1 136 GLY 136 179 179 GLY GLY A . n 
A 1 137 GLY 137 180 180 GLY GLY A . n 
A 1 138 GLY 138 181 181 GLY GLY A . n 
A 1 139 GLU 139 182 182 GLU GLU A . n 
A 1 140 GLY 140 183 183 GLY GLY A . n 
A 1 141 PRO 141 184 184 PRO PRO A . n 
A 1 142 MET 142 185 185 MET MET A . n 
A 1 143 HIS 143 186 186 HIS HIS A . n 
A 1 144 TYR 144 187 187 TYR TYR A . n 
A 1 145 TYR 145 188 188 TYR TYR A . n 
A 1 146 ASP 146 189 189 ASP ASP A . n 
A 1 147 THR 147 190 190 THR THR A . n 
A 1 148 LEU 148 191 191 LEU LEU A . n 
A 1 149 GLN 149 192 192 GLN GLN A . n 
A 1 150 LYS 150 193 193 LYS LYS A . n 
A 1 151 ILE 151 194 194 ILE ILE A . n 
A 1 152 ASP 152 195 195 ASP ASP A . n 
A 1 153 LEU 153 196 196 LEU LEU A . n 
A 1 154 THR 154 197 197 THR THR A . n 
A 1 155 ASP 155 198 198 ASP ASP A . n 
A 1 156 SER 156 199 199 SER SER A . n 
A 1 157 GLY 157 200 200 GLY GLY A . n 
A 1 158 LYS 158 201 201 LYS LYS A . n 
A 1 159 PHE 159 202 202 PHE PHE A . n 
A 1 160 SER 160 203 203 SER SER A . n 
A 1 161 ARG 161 204 204 ARG ARG A . n 
A 1 162 GLU 162 205 205 GLU GLU A . n 
A 1 163 ASN 163 206 206 ASN ASN A . n 
A 1 164 LYS 164 207 207 LYS LYS A . n 
A 1 165 GLN 165 208 208 GLN GLN A . n 
A 1 166 ASP 166 209 209 ASP ASP A . n 
A 1 167 ASP 167 210 210 ASP ASP A . n 
A 1 168 THR 168 211 211 THR THR A . n 
A 1 169 ALA 169 212 212 ALA ALA A . n 
A 1 170 ALA 170 213 213 ALA ALA A . n 
A 1 171 SER 171 214 214 SER SER A . n 
A 1 172 ILE 172 215 215 ILE ILE A . n 
A 1 173 PRO 173 216 216 PRO PRO A . n 
A 1 174 VAL 174 217 217 VAL VAL A . n 
A 1 175 SER 175 218 218 SER SER A . n 
A 1 176 ASP 176 219 219 ASP ASP A . n 
A 1 177 ILE 177 220 220 ILE ILE A . n 
A 1 178 TYR 178 221 221 TYR TYR A . n 
A 1 179 ILE 179 222 222 ILE ILE A . n 
A 1 180 ALA 180 223 223 ALA ALA A . n 
A 1 181 ASP 181 224 224 ASP ASP A . n 
A 1 182 GLY 182 225 225 GLY GLY A . n 
A 1 183 GLY 183 226 226 GLY GLY A . n 
A 1 184 ILE 184 227 227 ILE ILE A . n 
A 1 185 THR 185 228 228 THR THR A . n 
A 1 186 VAL 186 229 229 VAL VAL A . n 
A 1 187 GLY 187 230 230 GLY GLY A . n 
A 1 188 ASP 188 231 231 ASP ASP A . n 
A 1 189 ALA 189 232 232 ALA ALA A . n 
A 1 190 SER 190 233 233 SER SER A . n 
A 1 191 ALA 191 234 234 ALA ALA A . n 
A 1 192 THR 192 235 235 THR THR A . n 
A 1 193 ARG 193 236 236 ARG ARG A . n 
A 1 194 ARG 194 237 237 ARG ARG A . n 
A 1 195 GLU 195 238 238 GLU GLU A . n 
A 1 196 VAL 196 239 239 VAL VAL A . n 
A 1 197 HIS 197 240 240 HIS HIS A . n 
A 1 198 THR 198 241 241 THR THR A . n 
A 1 199 PRO 199 242 242 PRO PRO A . n 
A 1 200 VAL 200 243 243 VAL VAL A . n 
A 1 201 GLN 201 244 244 GLN GLN A . n 
A 1 202 GLU 202 245 245 GLU GLU A . n 
A 1 203 THR 203 246 246 THR THR A . n 
A 1 204 SER 204 247 247 SER SER A . n 
A 1 205 ASP 205 248 248 ASP ASP A . n 
A 1 206 SER 206 249 249 SER SER A . n 
A 1 207 ALA 207 250 250 ALA ALA A . n 
A 1 208 GLN 208 251 251 GLN GLN A . n 
A 1 209 VAL 209 252 252 VAL VAL A . n 
A 1 210 SER 210 253 253 SER SER A . n 
A 1 211 ILE 211 254 254 ILE ILE A . n 
A 1 212 GLY 212 255 255 GLY GLY A . n 
A 1 213 TRP 213 256 256 TRP TRP A . n 
A 1 214 PRO 214 257 257 PRO PRO A . n 
A 1 215 GLY 215 258 258 GLY GLY A . n 
A 1 216 LYS 216 259 259 LYS LYS A . n 
A 1 217 VAL 217 260 260 VAL VAL A . n 
A 1 218 ILE 218 261 261 ILE ILE A . n 
A 1 219 ALA 219 262 262 ALA ALA A . n 
A 1 220 ALA 220 263 263 ALA ALA A . n 
A 1 221 GLY 221 264 264 GLY GLY A . n 
A 1 222 SER 222 265 265 SER SER A . n 
A 1 223 VAL 223 266 266 VAL VAL A . n 
A 1 224 ILE 224 267 267 ILE ILE A . n 
A 1 225 GLU 225 268 268 GLU GLU A . n 
A 1 226 ILE 226 269 269 ILE ILE A . n 
A 1 227 GLY 227 270 270 GLY GLY A . n 
A 1 228 GLU 228 271 271 GLU GLU A . n 
A 1 229 SER 229 272 272 SER SER A . n 
A 1 230 PHE 230 273 273 PHE PHE A . n 
A 1 231 ALA 231 274 274 ALA ALA A . n 
A 1 232 VAL 232 275 275 VAL VAL A . n 
A 1 233 VAL 233 276 276 VAL VAL A . n 
A 1 234 HIS 234 277 277 HIS HIS A . n 
A 1 235 PRO 235 278 278 PRO PRO A . n 
A 1 236 GLY 236 279 279 GLY GLY A . n 
A 1 237 ASP 237 280 280 ASP ASP A . n 
A 1 238 TYR 238 281 281 TYR TYR A . n 
A 1 239 TYR 239 282 282 TYR TYR A . n 
A 1 240 ASN 240 283 283 ASN ASN A . n 
A 1 241 GLY 241 284 284 GLY GLY A . n 
A 1 242 LEU 242 285 285 LEU LEU A . n 
A 1 243 ARG 243 286 286 ARG ARG A . n 
A 1 244 GLY 244 287 287 GLY GLY A . n 
A 1 245 TYR 245 288 288 TYR TYR A . n 
A 1 246 LYS 246 289 289 LYS LYS A . n 
A 1 247 ASN 247 290 290 ASN ASN A . n 
A 1 248 ALA 248 291 291 ALA ALA A . n 
A 1 249 MET 249 292 292 MET MET A . n 
A 1 250 ASP 250 293 293 ASP ASP A . n 
A 1 251 HIS 251 294 294 HIS HIS A . n 
A 1 252 LEU 252 295 295 LEU LEU A . n 
A 1 253 GLY 253 296 296 GLY GLY A . n 
A 1 254 VAL 254 297 297 VAL VAL A . n 
A 1 255 ILE 255 298 298 ILE ILE A . n 
A 1 256 MET 256 299 299 MET MET A . n 
A 1 257 PRO 257 300 300 PRO PRO A . n 
A 1 258 ALA 258 301 301 ALA ALA A . n 
A 1 259 PRO 259 302 302 PRO PRO A . n 
A 1 260 GLY 260 303 303 GLY GLY A . n 
A 1 261 ASP 261 304 304 ASP ASP A . n 
A 1 262 ILE 262 305 305 ILE ILE A . n 
A 1 263 PRO 263 306 306 PRO PRO A . n 
A 1 264 ASP 264 307 307 ASP ASP A . n 
A 1 265 SER 265 308 308 SER SER A . n 
A 1 266 SER 266 309 309 SER SER A . n 
A 1 267 TYR 267 310 310 TYR TYR A . n 
A 1 268 ASP 268 311 311 ASP ASP A . n 
A 1 269 LEU 269 312 312 LEU LEU A . n 
A 1 270 ARG 270 313 313 ARG ARG A . n 
A 1 271 TRP 271 314 314 TRP TRP A . n 
A 1 272 GLU 272 315 315 GLU GLU A . n 
A 1 273 SER 273 316 316 SER SER A . n 
A 1 274 TRP 274 317 317 TRP TRP A . n 
A 1 275 GLY 275 318 318 GLY GLY A . n 
A 1 276 TRP 276 319 319 TRP TRP A . n 
A 1 277 GLY 277 320 320 GLY GLY A . n 
A 1 278 PHE 278 321 321 PHE PHE A . n 
A 1 279 ASN 279 322 322 ASN ASN A . n 
A 1 280 TRP 280 323 323 TRP TRP A . n 
A 1 281 THR 281 324 324 THR THR A . n 
A 1 282 ILE 282 325 325 ILE ILE A . n 
A 1 283 ASP 283 326 326 ASP ASP A . n 
A 1 284 LEU 284 327 327 LEU LEU A . n 
A 1 285 ILE 285 328 328 ILE ILE A . n 
A 1 286 ILE 286 329 329 ILE ILE A . n 
A 1 287 GLY 287 330 330 GLY GLY A . n 
A 1 288 LYS 288 331 331 LYS LYS A . n 
A 1 289 LEU 289 332 332 LEU LEU A . n 
A 1 290 ASP 290 333 333 ASP ASP A . n 
A 1 291 GLU 291 334 334 GLU GLU A . n 
A 1 292 LEU 292 335 335 LEU LEU A . n 
A 1 293 GLN 293 336 336 GLN GLN A . n 
A 1 294 ALA 294 337 337 ALA ALA A . n 
A 1 295 ALA 295 338 338 ALA ALA A . n 
A 1 296 GLY 296 339 339 GLY GLY A . n 
A 1 297 VAL 297 340 340 VAL VAL A . n 
A 1 298 LYS 298 341 341 LYS LYS A . n 
A 1 299 GLN 299 342 342 GLN GLN A . n 
A 1 300 ILE 300 343 343 ILE ILE A . n 
A 1 301 THR 301 344 344 THR THR A . n 
A 1 302 LEU 302 345 345 LEU LEU A . n 
A 1 303 ASP 303 346 346 ASP ASP A . n 
A 1 304 ASP 304 347 347 ASP ASP A . n 
A 1 305 GLY 305 348 348 GLY GLY A . n 
A 1 306 TRP 306 349 349 TRP TRP A . n 
A 1 307 TYR 307 350 350 TYR TYR A . n 
A 1 308 THR 308 351 351 THR THR A . n 
A 1 309 ASN 309 352 352 ASN ASN A . n 
A 1 310 ALA 310 353 353 ALA ALA A . n 
A 1 311 GLY 311 354 354 GLY GLY A . n 
A 1 312 ASP 312 355 355 ASP ASP A . n 
A 1 313 TRP 313 356 356 TRP TRP A . n 
A 1 314 ALA 314 357 357 ALA ALA A . n 
A 1 315 LEU 315 358 358 LEU LEU A . n 
A 1 316 ASN 316 359 359 ASN ASN A . n 
A 1 317 PRO 317 360 360 PRO PRO A . n 
A 1 318 GLU 318 361 361 GLU GLU A . n 
A 1 319 LYS 319 362 362 LYS LYS A . n 
A 1 320 PHE 320 363 363 PHE PHE A . n 
A 1 321 PRO 321 364 364 PRO PRO A . n 
A 1 322 ASN 322 365 365 ASN ASN A . n 
A 1 323 GLY 323 366 366 GLY GLY A . n 
A 1 324 ALA 324 367 367 ALA ALA A . n 
A 1 325 SER 325 368 368 SER SER A . n 
A 1 326 ASP 326 369 369 ASP ASP A . n 
A 1 327 ALA 327 370 370 ALA ALA A . n 
A 1 328 LEU 328 371 371 LEU LEU A . n 
A 1 329 ARG 329 372 372 ARG ARG A . n 
A 1 330 LEU 330 373 373 LEU LEU A . n 
A 1 331 THR 331 374 374 THR THR A . n 
A 1 332 ASP 332 375 375 ASP ASP A . n 
A 1 333 ALA 333 376 376 ALA ALA A . n 
A 1 334 ILE 334 377 377 ILE ILE A . n 
A 1 335 HIS 335 378 378 HIS HIS A . n 
A 1 336 GLU 336 379 379 GLU GLU A . n 
A 1 337 HIS 337 380 380 HIS HIS A . n 
A 1 338 GLY 338 381 381 GLY GLY A . n 
A 1 339 MET 339 382 382 MET MET A . n 
A 1 340 THR 340 383 383 THR THR A . n 
A 1 341 ALA 341 384 384 ALA ALA A . n 
A 1 342 LEU 342 385 385 LEU LEU A . n 
A 1 343 LEU 343 386 386 LEU LEU A . n 
A 1 344 TRP 344 387 387 TRP TRP A . n 
A 1 345 TRP 345 388 388 TRP TRP A . n 
A 1 346 ARG 346 389 389 ARG ARG A . n 
A 1 347 PRO 347 390 390 PRO PRO A . n 
A 1 348 CYS 348 391 391 CYS CYS A . n 
A 1 349 ASP 349 392 392 ASP ASP A . n 
A 1 350 GLY 350 393 393 GLY GLY A . n 
A 1 351 GLY 351 394 394 GLY GLY A . n 
A 1 352 ILE 352 395 395 ILE ILE A . n 
A 1 353 ASP 353 396 396 ASP ASP A . n 
A 1 354 SER 354 397 397 SER SER A . n 
A 1 355 ILE 355 398 398 ILE ILE A . n 
A 1 356 LEU 356 399 399 LEU LEU A . n 
A 1 357 TYR 357 400 400 TYR TYR A . n 
A 1 358 GLN 358 401 401 GLN GLN A . n 
A 1 359 GLN 359 402 402 GLN GLN A . n 
A 1 360 HIS 360 403 403 HIS HIS A . n 
A 1 361 PRO 361 404 404 PRO PRO A . n 
A 1 362 GLU 362 405 405 GLU GLU A . n 
A 1 363 TYR 363 406 406 TYR TYR A . n 
A 1 364 PHE 364 407 407 PHE PHE A . n 
A 1 365 VAL 365 408 408 VAL VAL A . n 
A 1 366 MET 366 409 409 MET MET A . n 
A 1 367 ASP 367 410 410 ASP ASP A . n 
A 1 368 ALA 368 411 411 ALA ALA A . n 
A 1 369 ASP 369 412 412 ASP ASP A . n 
A 1 370 GLY 370 413 413 GLY GLY A . n 
A 1 371 ARG 371 414 414 ARG ARG A . n 
A 1 372 PRO 372 415 415 PRO PRO A . n 
A 1 373 ALA 373 416 416 ALA ALA A . n 
A 1 374 ARG 374 417 417 ARG ARG A . n 
A 1 375 LEU 375 418 418 LEU LEU A . n 
A 1 376 PRO 376 419 419 PRO PRO A . n 
A 1 377 THR 377 420 420 THR THR A . n 
A 1 378 PRO 378 421 421 PRO PRO A . n 
A 1 379 GLY 379 422 422 GLY GLY A . n 
A 1 380 GLY 380 423 423 GLY GLY A . n 
A 1 381 GLY 381 424 424 GLY GLY A . n 
A 1 382 THR 382 425 425 THR THR A . n 
A 1 383 ASN 383 426 426 ASN ASN A . n 
A 1 384 PRO 384 427 427 PRO PRO A . n 
A 1 385 SER 385 428 428 SER SER A . n 
A 1 386 LEU 386 429 429 LEU LEU A . n 
A 1 387 GLY 387 430 430 GLY GLY A . n 
A 1 388 TYR 388 431 431 TYR TYR A . n 
A 1 389 ALA 389 432 432 ALA ALA A . n 
A 1 390 LEU 390 433 433 LEU LEU A . n 
A 1 391 CYS 391 434 434 CYS CYS A . n 
A 1 392 PRO 392 435 435 PRO PRO A . n 
A 1 393 MET 393 436 436 MET MET A . n 
A 1 394 ALA 394 437 437 ALA ALA A . n 
A 1 395 ASP 395 438 438 ASP ASP A . n 
A 1 396 GLY 396 439 439 GLY GLY A . n 
A 1 397 ALA 397 440 440 ALA ALA A . n 
A 1 398 ILE 398 441 441 ILE ILE A . n 
A 1 399 ALA 399 442 442 ALA ALA A . n 
A 1 400 SER 400 443 443 SER SER A . n 
A 1 401 GLN 401 444 444 GLN GLN A . n 
A 1 402 VAL 402 445 445 VAL VAL A . n 
A 1 403 ASP 403 446 446 ASP ASP A . n 
A 1 404 PHE 404 447 447 PHE PHE A . n 
A 1 405 VAL 405 448 448 VAL VAL A . n 
A 1 406 ASN 406 449 449 ASN ASN A . n 
A 1 407 ARG 407 450 450 ARG ARG A . n 
A 1 408 ALA 408 451 451 ALA ALA A . n 
A 1 409 MET 409 452 452 MET MET A . n 
A 1 410 ASN 410 453 453 ASN ASN A . n 
A 1 411 ASP 411 454 454 ASP ASP A . n 
A 1 412 TRP 412 455 455 TRP TRP A . n 
A 1 413 GLY 413 456 456 GLY GLY A . n 
A 1 414 PHE 414 457 457 PHE PHE A . n 
A 1 415 ASP 415 458 458 ASP ASP A . n 
A 1 416 GLY 416 459 459 GLY GLY A . n 
A 1 417 PHE 417 460 460 PHE PHE A . n 
A 1 418 LYS 418 461 461 LYS LYS A . n 
A 1 419 GLY 419 462 462 GLY GLY A . n 
A 1 420 ASP 420 463 463 ASP ASP A . n 
A 1 421 TYR 421 464 464 TYR TYR A . n 
A 1 422 VAL 422 465 465 VAL VAL A . n 
A 1 423 TRP 423 466 466 TRP TRP A . n 
A 1 424 SER 424 467 467 SER SER A . n 
A 1 425 MET 425 468 468 MET MET A . n 
A 1 426 PRO 426 469 469 PRO PRO A . n 
A 1 427 GLU 427 470 470 GLU GLU A . n 
A 1 428 CYS 428 471 471 CYS CYS A . n 
A 1 429 TYR 429 472 472 TYR TYR A . n 
A 1 430 ASN 430 473 473 ASN ASN A . n 
A 1 431 PRO 431 474 474 PRO PRO A . n 
A 1 432 ALA 432 475 475 ALA ALA A . n 
A 1 433 HIS 433 476 476 HIS HIS A . n 
A 1 434 ASN 434 477 477 ASN ASN A . n 
A 1 435 HIS 435 478 478 HIS HIS A . n 
A 1 436 ALA 436 479 479 ALA ALA A . n 
A 1 437 SER 437 480 480 SER SER A . n 
A 1 438 PRO 438 481 481 PRO PRO A . n 
A 1 439 GLU 439 482 482 GLU GLU A . n 
A 1 440 GLU 440 483 483 GLU GLU A . n 
A 1 441 SER 441 484 484 SER SER A . n 
A 1 442 THR 442 485 485 THR THR A . n 
A 1 443 GLU 443 486 486 GLU GLU A . n 
A 1 444 LYS 444 487 487 LYS LYS A . n 
A 1 445 GLN 445 488 488 GLN GLN A . n 
A 1 446 SER 446 489 489 SER SER A . n 
A 1 447 GLU 447 490 490 GLU GLU A . n 
A 1 448 ILE 448 491 491 ILE ILE A . n 
A 1 449 TYR 449 492 492 TYR TYR A . n 
A 1 450 ARG 450 493 493 ARG ARG A . n 
A 1 451 VAL 451 494 494 VAL VAL A . n 
A 1 452 SER 452 495 495 SER SER A . n 
A 1 453 TYR 453 496 496 TYR TYR A . n 
A 1 454 GLU 454 497 497 GLU GLU A . n 
A 1 455 ALA 455 498 498 ALA ALA A . n 
A 1 456 MET 456 499 499 MET MET A . n 
A 1 457 VAL 457 500 500 VAL VAL A . n 
A 1 458 ALA 458 501 501 ALA ALA A . n 
A 1 459 ASN 459 502 502 ASN ASN A . n 
A 1 460 ASP 460 503 503 ASP ASP A . n 
A 1 461 PRO 461 504 504 PRO PRO A . n 
A 1 462 ASN 462 505 505 ASN ASN A . n 
A 1 463 VAL 463 506 506 VAL VAL A . n 
A 1 464 PHE 464 507 507 PHE PHE A . n 
A 1 465 ASN 465 508 508 ASN ASN A . n 
A 1 466 LEU 466 509 509 LEU LEU A . n 
A 1 467 LEU 467 510 510 LEU LEU A . n 
A 1 468 CYS 468 511 511 CYS CYS A . n 
A 1 469 ASN 469 512 512 ASN ASN A . n 
A 1 470 CYS 470 513 513 CYS CYS A . n 
A 1 471 GLY 471 514 514 GLY GLY A . n 
A 1 472 THR 472 515 515 THR THR A . n 
A 1 473 PRO 473 516 516 PRO PRO A . n 
A 1 474 GLN 474 517 517 GLN GLN A . n 
A 1 475 ASP 475 518 518 ASP ASP A . n 
A 1 476 TYR 476 519 519 TYR TYR A . n 
A 1 477 TYR 477 520 520 TYR TYR A . n 
A 1 478 SER 478 521 521 SER SER A . n 
A 1 479 LEU 479 522 522 LEU LEU A . n 
A 1 480 PRO 480 523 523 PRO PRO A . n 
A 1 481 TYR 481 524 524 TYR TYR A . n 
A 1 482 MET 482 525 525 MET MET A . n 
A 1 483 THR 483 526 526 THR THR A . n 
A 1 484 GLN 484 527 527 GLN GLN A . n 
A 1 485 ILE 485 528 528 ILE ILE A . n 
A 1 486 ALA 486 529 529 ALA ALA A . n 
A 1 487 THR 487 530 530 THR THR A . n 
A 1 488 ALA 488 531 531 ALA ALA A . n 
A 1 489 ASP 489 532 532 ASP ASP A . n 
A 1 490 PRO 490 533 533 PRO PRO A . n 
A 1 491 THR 491 534 534 THR THR A . n 
A 1 492 SER 492 535 535 SER SER A . n 
A 1 493 VAL 493 536 536 VAL VAL A . n 
A 1 494 ASP 494 537 537 ASP ASP A . n 
A 1 495 GLN 495 538 538 GLN GLN A . n 
A 1 496 THR 496 539 539 THR THR A . n 
A 1 497 ARG 497 540 540 ARG ARG A . n 
A 1 498 ARG 498 541 541 ARG ARG A . n 
A 1 499 ARG 499 542 542 ARG ARG A . n 
A 1 500 VAL 500 543 543 VAL VAL A . n 
A 1 501 LYS 501 544 544 LYS LYS A . n 
A 1 502 ALA 502 545 545 ALA ALA A . n 
A 1 503 TYR 503 546 546 TYR TYR A . n 
A 1 504 LYS 504 547 547 LYS LYS A . n 
A 1 505 ALA 505 548 548 ALA ALA A . n 
A 1 506 LEU 506 549 549 LEU LEU A . n 
A 1 507 MET 507 550 550 MET MET A . n 
A 1 508 GLY 508 551 551 GLY GLY A . n 
A 1 509 ASP 509 552 552 ASP ASP A . n 
A 1 510 TYR 510 553 553 TYR TYR A . n 
A 1 511 PHE 511 554 554 PHE PHE A . n 
A 1 512 PRO 512 555 555 PRO PRO A . n 
A 1 513 VAL 513 556 556 VAL VAL A . n 
A 1 514 THR 514 557 557 THR THR A . n 
A 1 515 ALA 515 558 558 ALA ALA A . n 
A 1 516 ASP 516 559 559 ASP ASP A . n 
A 1 517 HIS 517 560 560 HIS HIS A . n 
A 1 518 ASN 518 561 561 ASN ASN A . n 
A 1 519 ASN 519 562 562 ASN ASN A . n 
A 1 520 ILE 520 563 563 ILE ILE A . n 
A 1 521 TRP 521 564 564 TRP TRP A . n 
A 1 522 TYR 522 565 565 TYR TYR A . n 
A 1 523 LEU 523 566 566 LEU LEU A . n 
A 1 524 SER 524 567 567 SER SER A . n 
A 1 525 ALA 525 568 568 ALA ALA A . n 
A 1 526 VAL 526 569 569 VAL VAL A . n 
A 1 527 GLY 527 570 570 GLY GLY A . n 
A 1 528 THR 528 571 571 THR THR A . n 
A 1 529 GLY 529 572 572 GLY GLY A . n 
A 1 530 SER 530 573 573 SER SER A . n 
A 1 531 VAL 531 574 574 VAL VAL A . n 
A 1 532 LEU 532 575 575 LEU LEU A . n 
A 1 533 ILE 533 576 576 ILE ILE A . n 
A 1 534 GLU 534 577 577 GLU GLU A . n 
A 1 535 LYS 535 578 578 LYS LYS A . n 
A 1 536 ARG 536 579 579 ARG ARG A . n 
A 1 537 ASP 537 580 580 ASP ASP A . n 
A 1 538 LEU 538 581 581 LEU LEU A . n 
A 1 539 SER 539 582 582 SER SER A . n 
A 1 540 GLY 540 583 583 GLY GLY A . n 
A 1 541 THR 541 584 584 THR THR A . n 
A 1 542 ALA 542 585 585 ALA ALA A . n 
A 1 543 LYS 543 586 586 LYS LYS A . n 
A 1 544 GLU 544 587 587 GLU GLU A . n 
A 1 545 GLU 545 588 588 GLU GLU A . n 
A 1 546 TYR 546 589 589 TYR TYR A . n 
A 1 547 GLU 547 590 590 GLU GLU A . n 
A 1 548 LYS 548 591 591 LYS LYS A . n 
A 1 549 TRP 549 592 592 TRP TRP A . n 
A 1 550 LEU 550 593 593 LEU LEU A . n 
A 1 551 GLY 551 594 594 GLY GLY A . n 
A 1 552 ILE 552 595 595 ILE ILE A . n 
A 1 553 ALA 553 596 596 ALA ALA A . n 
A 1 554 ASP 554 597 597 ASP ASP A . n 
A 1 555 THR 555 598 598 THR THR A . n 
A 1 556 VAL 556 599 599 VAL VAL A . n 
A 1 557 GLN 557 600 600 GLN GLN A . n 
A 1 558 LEU 558 601 601 LEU LEU A . n 
A 1 559 GLN 559 602 602 GLN GLN A . n 
A 1 560 LYS 560 603 603 LYS LYS A . n 
A 1 561 GLY 561 604 604 GLY GLY A . n 
A 1 562 ARG 562 605 605 ARG ARG A . n 
A 1 563 PHE 563 606 606 PHE PHE A . n 
A 1 564 ILE 564 607 607 ILE ILE A . n 
A 1 565 GLY 565 608 608 GLY GLY A . n 
A 1 566 ASP 566 609 609 ASP ASP A . n 
A 1 567 LEU 567 610 610 LEU LEU A . n 
A 1 568 TYR 568 611 611 TYR TYR A . n 
A 1 569 SER 569 612 612 SER SER A . n 
A 1 570 TYR 570 613 613 TYR TYR A . n 
A 1 571 GLY 571 614 614 GLY GLY A . n 
A 1 572 PHE 572 615 615 PHE PHE A . n 
A 1 573 ASP 573 616 616 ASP ASP A . n 
A 1 574 PRO 574 617 617 PRO PRO A . n 
A 1 575 TYR 575 618 618 TYR TYR A . n 
A 1 576 GLU 576 619 619 GLU GLU A . n 
A 1 577 THR 577 620 620 THR THR A . n 
A 1 578 TYR 578 621 621 TYR TYR A . n 
A 1 579 VAL 579 622 622 VAL VAL A . n 
A 1 580 VAL 580 623 623 VAL VAL A . n 
A 1 581 GLU 581 624 624 GLU GLU A . n 
A 1 582 LYS 582 625 625 LYS LYS A . n 
A 1 583 ASP 583 626 626 ASP ASP A . n 
A 1 584 GLY 584 627 627 GLY GLY A . n 
A 1 585 VAL 585 628 628 VAL VAL A . n 
A 1 586 MET 586 629 629 MET MET A . n 
A 1 587 TYR 587 630 630 TYR TYR A . n 
A 1 588 TYR 588 631 631 TYR TYR A . n 
A 1 589 ALA 589 632 632 ALA ALA A . n 
A 1 590 PHE 590 633 633 PHE PHE A . n 
A 1 591 TYR 591 634 634 TYR TYR A . n 
A 1 592 LYS 592 635 635 LYS LYS A . n 
A 1 593 ASP 593 636 636 ASP ASP A . n 
A 1 594 GLY 594 637 637 GLY GLY A . n 
A 1 595 SER 595 638 638 SER SER A . n 
A 1 596 LYS 596 639 639 LYS LYS A . n 
A 1 597 TYR 597 640 640 TYR TYR A . n 
A 1 598 SER 598 641 641 SER SER A . n 
A 1 599 PRO 599 642 642 PRO PRO A . n 
A 1 600 THR 600 643 643 THR THR A . n 
A 1 601 GLY 601 644 644 GLY GLY A . n 
A 1 602 TYR 602 645 645 TYR TYR A . n 
A 1 603 PRO 603 646 646 PRO PRO A . n 
A 1 604 ASP 604 647 647 ASP ASP A . n 
A 1 605 ILE 605 648 648 ILE ILE A . n 
A 1 606 GLU 606 649 649 GLU GLU A . n 
A 1 607 LEU 607 650 650 LEU LEU A . n 
A 1 608 LYS 608 651 651 LYS LYS A . n 
A 1 609 GLY 609 652 652 GLY GLY A . n 
A 1 610 LEU 610 653 653 LEU LEU A . n 
A 1 611 ASP 611 654 654 ASP ASP A . n 
A 1 612 PRO 612 655 655 PRO PRO A . n 
A 1 613 ASN 613 656 656 ASN ASN A . n 
A 1 614 LYS 614 657 657 LYS LYS A . n 
A 1 615 MET 615 658 658 MET MET A . n 
A 1 616 TYR 616 659 659 TYR TYR A . n 
A 1 617 ARG 617 660 660 ARG ARG A . n 
A 1 618 ILE 618 661 661 ILE ILE A . n 
A 1 619 VAL 619 662 662 VAL VAL A . n 
A 1 620 ASP 620 663 663 ASP ASP A . n 
A 1 621 TYR 621 664 664 TYR TYR A . n 
A 1 622 VAL 622 665 665 VAL VAL A . n 
A 1 623 ASN 623 666 666 ASN ASN A . n 
A 1 624 ASP 624 667 667 ASP ASP A . n 
A 1 625 ARG 625 668 668 ARG ARG A . n 
A 1 626 VAL 626 669 669 VAL VAL A . n 
A 1 627 VAL 627 670 670 VAL VAL A . n 
A 1 628 ALA 628 671 671 ALA ALA A . n 
A 1 629 THR 629 672 672 THR THR A . n 
A 1 630 ASN 630 673 673 ASN ASN A . n 
A 1 631 LEU 631 674 674 LEU LEU A . n 
A 1 632 MET 632 675 675 MET MET A . n 
A 1 633 GLY 633 676 676 GLY GLY A . n 
A 1 634 ASP 634 677 677 ASP ASP A . n 
A 1 635 ASN 635 678 678 ASN ASN A . n 
A 1 636 ALA 636 679 679 ALA ALA A . n 
A 1 637 VAL 637 680 680 VAL VAL A . n 
A 1 638 PHE 638 681 681 PHE PHE A . n 
A 1 639 ASN 639 682 682 ASN ASN A . n 
A 1 640 THR 640 683 683 THR THR A . n 
A 1 641 ARG 641 684 684 ARG ARG A . n 
A 1 642 PHE 642 685 685 PHE PHE A . n 
A 1 643 SER 643 686 686 SER SER A . n 
A 1 644 ASP 644 687 687 ASP ASP A . n 
A 1 645 TYR 645 688 688 TYR TYR A . n 
A 1 646 LEU 646 689 689 LEU LEU A . n 
A 1 647 LEU 647 690 690 LEU LEU A . n 
A 1 648 VAL 648 691 691 VAL VAL A . n 
A 1 649 LYS 649 692 692 LYS LYS A . n 
A 1 650 ALA 650 693 693 ALA ALA A . n 
A 1 651 VAL 651 694 694 VAL VAL A . n 
A 1 652 GLU 652 695 695 GLU GLU A . n 
A 1 653 ILE 653 696 696 ILE ILE A . n 
A 1 654 SER 654 697 697 SER SER A . n 
A 1 655 GLU 655 698 698 GLU GLU A . n 
A 1 656 PRO 656 699 699 PRO PRO A . n 
A 1 657 ASP 657 700 700 ASP ASP A . n 
A 1 658 PRO 658 701 701 PRO PRO A . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8X1B 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8X1B 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8X1B 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8X1B 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 5241 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.521 ? 7143 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 4.052 ? 724  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.045 ? 753  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 941  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8X1B 
_struct.title                        'Cryo-EM structure of FpGalactosaminidase from Flavonifractor plautii in apo state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8X1B 
_struct_keywords.text            'Flavonifractor plautii, A to O type blood, D-(+)-Galactosamine hydrochloride, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A174W4Y6_FLAPL 
_struct_ref.pdbx_db_accession          A0A174W4Y6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;YAIAGNGVRVTYDADGQTITLYRTEGSGLIQMSKPSPLGGPVVGGQEVQDFSHISCDVEQSTSGVMGSGQRMTITSQSMS
TGLIRTYVLETSDIEEGVVYTATSYEAGASDVEVSWFIGSVYELYGAEDRIWSYNGGGEGPMHYYDTLQKIDLTDSGKFS
RENKQDDTAASIPVSDIYIADGGITVGDASATRREVHTPVQETSDSAQVSIGWPGKVIAAGSVIEIGESFAVVHPGDYYN
GLRGYKNAMDHLGVIMPAPGDIPDSSYDLRWESWGWGFNWTIDLIIGKLDELQAAGVKQITLDDGWYTNAGDWALNPEKF
PNGASDALRLTDAIHEHGMTALLWWRPCDGGIDSILYQQHPEYFVMDADGRPARLPTPGGGTNPSLGYALCPMADGAIAS
QVDFVNRAMNDWGFDGFKGDYVWSMPECYNPAHNHASPEESTEKQSEIYRVSYEAMVANDPNVFNLLCNCGTPQDYYSLP
YMTQIATADPTSVDQTRRRVKAYKALMGDYFPVTADHNNIWYPSAVGTGSVLIEKRDLSGTAKEEYEKWLGIADTVQLQK
GRFIGDLYSYGFDPYETYVVEKDGVMYYAFYKDGSKYSPTGYPDIELKGLDPNKMYRIVDYVNDRVVATNLMGDNAVFNT
RFSDYLLVKAVEISEPDP
;
_struct_ref.pdbx_align_begin           44 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8X1B 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 658 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A174W4Y6 
_struct_ref_seq.db_align_beg                  44 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  701 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       44 
_struct_ref_seq.pdbx_auth_seq_align_end       701 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8X1B 
_struct_ref_seq_dif.mon_id                       LEU 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      523 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   A0A174W4Y6 
_struct_ref_seq_dif.db_mon_id                    PRO 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          566 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            566 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 237 ? ASP A 250 ? ASP A 280 ASP A 293 1 ? 14 
HELX_P HELX_P2  AA2 HIS A 251 ? GLY A 253 ? HIS A 294 GLY A 296 5 ? 3  
HELX_P HELX_P3  AA3 ALA A 258 ? ILE A 262 ? ALA A 301 ILE A 305 5 ? 5  
HELX_P HELX_P4  AA4 THR A 281 ? LYS A 288 ? THR A 324 LYS A 331 1 ? 8  
HELX_P HELX_P5  AA5 LYS A 288 ? GLY A 296 ? LYS A 331 GLY A 339 1 ? 9  
HELX_P HELX_P6  AA6 GLY A 323 ? HIS A 337 ? GLY A 366 HIS A 380 1 ? 15 
HELX_P HELX_P7  AA7 SER A 354 ? HIS A 360 ? SER A 397 HIS A 403 1 ? 7  
HELX_P HELX_P8  AA8 PRO A 361 ? PHE A 364 ? PRO A 404 PHE A 407 5 ? 4  
HELX_P HELX_P9  AA9 ALA A 394 ? ASP A 411 ? ALA A 437 ASP A 454 1 ? 18 
HELX_P HELX_P10 AB1 SER A 437 ? THR A 442 ? SER A 480 THR A 485 5 ? 6  
HELX_P HELX_P11 AB2 LYS A 444 ? ASP A 460 ? LYS A 487 ASP A 503 1 ? 17 
HELX_P HELX_P12 AB3 ASP A 475 ? MET A 482 ? ASP A 518 MET A 525 5 ? 8  
HELX_P HELX_P13 AB4 SER A 492 ? GLY A 508 ? SER A 535 GLY A 551 1 ? 17 
HELX_P HELX_P14 AB5 TRP A 521 ? THR A 528 ? TRP A 564 THR A 571 1 ? 8  
HELX_P HELX_P15 AB6 GLY A 540 ? GLN A 557 ? GLY A 583 GLN A 600 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            468 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            470 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             511 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             513 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.036 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       468 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      470 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        511 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       513 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 5 ? 
AA5 ? 9 ? 
AA6 ? 2 ? 
AA7 ? 4 ? 
AA8 ? 6 ? 
AA9 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA5 6 7 ? anti-parallel 
AA5 7 8 ? anti-parallel 
AA5 8 9 ? anti-parallel 
AA6 1 2 ? parallel      
AA7 1 2 ? parallel      
AA7 2 3 ? parallel      
AA7 3 4 ? parallel      
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA8 4 5 ? anti-parallel 
AA8 5 6 ? anti-parallel 
AA9 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 2   ? ILE A 3   ? ALA A 45  ILE A 46  
AA1 2 VAL A 8   ? ASP A 13  ? VAL A 51  ASP A 56  
AA1 3 THR A 18  ? GLU A 25  ? THR A 61  GLU A 68  
AA1 4 GLY A 28  ? GLN A 31  ? GLY A 71  GLN A 74  
AA2 1 ALA A 2   ? ILE A 3   ? ALA A 45  ILE A 46  
AA2 2 VAL A 8   ? ASP A 13  ? VAL A 51  ASP A 56  
AA2 3 THR A 18  ? GLU A 25  ? THR A 61  GLU A 68  
AA2 4 SER A 36  ? PRO A 37  ? SER A 79  PRO A 80  
AA3 1 SER A 33  ? LYS A 34  ? SER A 76  LYS A 77  
AA3 2 TRP A 116 ? LEU A 124 ? TRP A 159 LEU A 167 
AA3 3 PRO A 41  ? VAL A 43  ? PRO A 84  VAL A 86  
AA3 4 GLN A 46  ? GLU A 47  ? GLN A 89  GLU A 90  
AA4 1 SER A 33  ? LYS A 34  ? SER A 76  LYS A 77  
AA4 2 TRP A 116 ? LEU A 124 ? TRP A 159 LEU A 167 
AA4 3 ALA A 207 ? PRO A 214 ? ALA A 250 PRO A 257 
AA4 4 VAL A 196 ? GLU A 202 ? VAL A 239 GLU A 245 
AA4 5 SER A 160 ? GLN A 165 ? SER A 203 GLN A 208 
AA5 1 PHE A 51  ? GLY A 64  ? PHE A 94  GLY A 107 
AA5 2 GLY A 67  ? SER A 78  ? GLY A 110 SER A 121 
AA5 3 LEU A 83  ? SER A 92  ? LEU A 126 SER A 135 
AA5 4 VAL A 98  ? ALA A 107 ? VAL A 141 ALA A 150 
AA5 5 SER A 222 ? HIS A 234 ? SER A 265 HIS A 277 
AA5 6 GLY A 183 ? ASP A 188 ? GLY A 226 ASP A 231 
AA5 7 VAL A 174 ? TYR A 178 ? VAL A 217 TYR A 221 
AA5 8 ARG A 130 ? TYR A 134 ? ARG A 173 TYR A 177 
AA5 9 LEU A 148 ? ASP A 152 ? LEU A 191 ASP A 195 
AA6 1 ARG A 270 ? TRP A 271 ? ARG A 313 TRP A 314 
AA6 2 ILE A 533 ? GLU A 534 ? ILE A 576 GLU A 577 
AA7 1 GLN A 299 ? LEU A 302 ? GLN A 342 LEU A 345 
AA7 2 THR A 340 ? TRP A 345 ? THR A 383 TRP A 388 
AA7 3 GLY A 416 ? ASP A 420 ? GLY A 459 ASP A 463 
AA7 4 PHE A 464 ? CYS A 468 ? PHE A 507 CYS A 511 
AA8 1 ARG A 562 ? ILE A 564 ? ARG A 605 ILE A 607 
AA8 2 GLU A 576 ? LYS A 582 ? GLU A 619 LYS A 625 
AA8 3 VAL A 585 ? TYR A 591 ? VAL A 628 TYR A 634 
AA8 4 TYR A 645 ? ILE A 653 ? TYR A 688 ILE A 696 
AA8 5 MET A 615 ? ASP A 620 ? MET A 658 ASP A 663 
AA8 6 ARG A 625 ? MET A 632 ? ARG A 668 MET A 675 
AA9 1 ILE A 605 ? GLU A 606 ? ILE A 648 GLU A 649 
AA9 2 VAL A 637 ? PHE A 638 ? VAL A 680 PHE A 681 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 3   ? N ILE A 46  O VAL A 10  ? O VAL A 53  
AA1 2 3 N THR A 11  ? N THR A 54  O THR A 20  ? O THR A 63  
AA1 3 4 N ARG A 23  ? N ARG A 66  O ILE A 30  ? O ILE A 73  
AA2 1 2 N ILE A 3   ? N ILE A 46  O VAL A 10  ? O VAL A 53  
AA2 2 3 N THR A 11  ? N THR A 54  O THR A 20  ? O THR A 63  
AA2 3 4 N ILE A 19  ? N ILE A 62  O SER A 36  ? O SER A 79  
AA3 1 2 N LYS A 34  ? N LYS A 77  O GLU A 123 ? O GLU A 166 
AA3 2 3 O TRP A 116 ? O TRP A 159 N VAL A 42  ? N VAL A 85  
AA3 3 4 N VAL A 43  ? N VAL A 86  O GLN A 46  ? O GLN A 89  
AA4 1 2 N LYS A 34  ? N LYS A 77  O GLU A 123 ? O GLU A 166 
AA4 2 3 N PHE A 117 ? N PHE A 160 O TRP A 213 ? O TRP A 256 
AA4 3 4 O GLN A 208 ? O GLN A 251 N GLN A 201 ? N GLN A 244 
AA4 4 5 O VAL A 200 ? O VAL A 243 N ARG A 161 ? N ARG A 204 
AA5 1 2 N GLU A 59  ? N GLU A 102 O ARG A 71  ? O ARG A 114 
AA5 2 3 N SER A 76  ? N SER A 119 O ARG A 85  ? O ARG A 128 
AA5 3 4 N GLU A 90  ? N GLU A 133 O TYR A 100 ? O TYR A 143 
AA5 4 5 N VAL A 99  ? N VAL A 142 O ALA A 231 ? O ALA A 274 
AA5 5 6 O PHE A 230 ? O PHE A 273 N GLY A 187 ? N GLY A 230 
AA5 6 7 O ILE A 184 ? O ILE A 227 N ILE A 177 ? N ILE A 220 
AA5 7 8 O ASP A 176 ? O ASP A 219 N TYR A 134 ? N TYR A 177 
AA5 8 9 N ILE A 131 ? N ILE A 174 O ILE A 151 ? O ILE A 194 
AA6 1 2 N ARG A 270 ? N ARG A 313 O GLU A 534 ? O GLU A 577 
AA7 1 2 N ILE A 300 ? N ILE A 343 O THR A 340 ? O THR A 383 
AA7 2 3 N LEU A 343 ? N LEU A 386 O LYS A 418 ? O LYS A 461 
AA7 3 4 N GLY A 419 ? N GLY A 462 O LEU A 466 ? O LEU A 509 
AA8 1 2 N ARG A 562 ? N ARG A 605 O GLU A 581 ? O GLU A 624 
AA8 2 3 N VAL A 580 ? N VAL A 623 O TYR A 587 ? O TYR A 630 
AA8 3 4 N TYR A 588 ? N TYR A 631 O VAL A 648 ? O VAL A 691 
AA8 4 5 O VAL A 651 ? O VAL A 694 N ARG A 617 ? N ARG A 660 
AA8 5 6 N ASP A 620 ? N ASP A 663 O ARG A 625 ? O ARG A 668 
AA9 1 2 N ILE A 605 ? N ILE A 648 O PHE A 638 ? O PHE A 681 
# 
_pdbx_entry_details.entry_id                   8X1B 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 49  ? ? -163.30 115.57  
2 1 ILE A 97  ? ? -106.97 -62.37  
3 1 ASP A 559 ? ? 62.10   -175.92 
4 1 HIS A 560 ? ? -140.91 26.01   
5 1 ASN A 656 ? ? -97.39  31.10   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8X1B 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8X1B 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.59 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               673717 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 'ORGANELLE OR CELLULAR COMPONENT' 
_em_entity_assembly.name                 FpGalactosaminidase 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8X1B 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8X1B 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8X1B 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-11-06 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8X1B 
_em_admin.last_update        2024-11-27 
_em_admin.map_release_date   2024-11-13 
_em_admin.title              'Cryo-EM structure of FpGalactosaminidase from Flavonifractor plautii in apo state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          292800 
_em_entity_assembly_naturalsource.organism             'Flavonifractor plautii' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          469008 
_em_entity_assembly_recombinant.organism             'Escherichia coli BL21(DE3)' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8X1B 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . TYR A 1 1   ? 107.215 98.834  150.730 1.00 42.63 ? 44  TYR A N   1 
ATOM 2    C CA  . TYR A 1 1   ? 107.336 100.262 150.464 1.00 47.11 ? 44  TYR A CA  1 
ATOM 3    C C   . TYR A 1 1   ? 107.558 100.525 148.980 1.00 49.50 ? 44  TYR A C   1 
ATOM 4    O O   . TYR A 1 1   ? 108.697 100.625 148.529 1.00 50.32 ? 44  TYR A O   1 
ATOM 5    C CB  . TYR A 1 1   ? 108.484 100.864 151.275 1.00 51.89 ? 44  TYR A CB  1 
ATOM 6    C CG  . TYR A 1 1   ? 108.290 100.790 152.772 1.00 56.07 ? 44  TYR A CG  1 
ATOM 7    C CD1 . TYR A 1 1   ? 109.314 100.354 153.601 1.00 55.40 ? 44  TYR A CD1 1 
ATOM 8    C CD2 . TYR A 1 1   ? 107.085 101.150 153.355 1.00 55.50 ? 44  TYR A CD2 1 
ATOM 9    C CE1 . TYR A 1 1   ? 109.144 100.284 154.968 1.00 49.94 ? 44  TYR A CE1 1 
ATOM 10   C CE2 . TYR A 1 1   ? 106.906 101.083 154.722 1.00 53.20 ? 44  TYR A CE2 1 
ATOM 11   C CZ  . TYR A 1 1   ? 107.939 100.649 155.523 1.00 50.41 ? 44  TYR A CZ  1 
ATOM 12   O OH  . TYR A 1 1   ? 107.765 100.579 156.885 1.00 57.32 ? 44  TYR A OH  1 
ATOM 13   N N   . ALA A 1 2   ? 106.470 100.642 148.222 1.00 43.41 ? 45  ALA A N   1 
ATOM 14   C CA  . ALA A 1 2   ? 106.577 100.857 146.787 1.00 42.35 ? 45  ALA A CA  1 
ATOM 15   C C   . ALA A 1 2   ? 105.400 101.685 146.295 1.00 43.19 ? 45  ALA A C   1 
ATOM 16   O O   . ALA A 1 2   ? 104.319 101.672 146.888 1.00 46.39 ? 45  ALA A O   1 
ATOM 17   C CB  . ALA A 1 2   ? 106.641 99.529  146.024 1.00 43.41 ? 45  ALA A CB  1 
ATOM 18   N N   . ILE A 1 3   ? 105.630 102.410 145.200 1.00 42.46 ? 46  ILE A N   1 
ATOM 19   C CA  . ILE A 1 3   ? 104.601 103.178 144.516 1.00 37.91 ? 46  ILE A CA  1 
ATOM 20   C C   . ILE A 1 3   ? 104.720 102.909 143.023 1.00 46.59 ? 46  ILE A C   1 
ATOM 21   O O   . ILE A 1 3   ? 105.783 102.548 142.515 1.00 56.96 ? 46  ILE A O   1 
ATOM 22   C CB  . ILE A 1 3   ? 104.706 104.692 144.797 1.00 45.01 ? 46  ILE A CB  1 
ATOM 23   C CG1 . ILE A 1 3   ? 106.119 105.190 144.500 1.00 42.68 ? 46  ILE A CG1 1 
ATOM 24   C CG2 . ILE A 1 3   ? 104.315 104.999 146.234 1.00 52.76 ? 46  ILE A CG2 1 
ATOM 25   C CD1 . ILE A 1 3   ? 106.249 106.690 144.506 1.00 48.56 ? 46  ILE A CD1 1 
ATOM 26   N N   . ALA A 1 4   ? 103.607 103.094 142.316 1.00 44.53 ? 47  ALA A N   1 
ATOM 27   C CA  . ALA A 1 4   ? 103.577 102.868 140.873 1.00 50.25 ? 47  ALA A CA  1 
ATOM 28   C C   . ALA A 1 4   ? 102.475 103.731 140.279 1.00 48.33 ? 47  ALA A C   1 
ATOM 29   O O   . ALA A 1 4   ? 101.293 103.401 140.411 1.00 52.15 ? 47  ALA A O   1 
ATOM 30   C CB  . ALA A 1 4   ? 103.351 101.393 140.552 1.00 54.11 ? 47  ALA A CB  1 
ATOM 31   N N   . GLY A 1 5   ? 102.856 104.829 139.632 1.00 54.66 ? 48  GLY A N   1 
ATOM 32   C CA  . GLY A 1 5   ? 101.873 105.714 139.043 1.00 59.39 ? 48  GLY A CA  1 
ATOM 33   C C   . GLY A 1 5   ? 101.465 105.348 137.631 1.00 58.72 ? 48  GLY A C   1 
ATOM 34   O O   . GLY A 1 5   ? 100.290 105.069 137.374 1.00 64.31 ? 48  GLY A O   1 
ATOM 35   N N   . ASN A 1 6   ? 102.425 105.336 136.707 1.00 51.45 ? 49  ASN A N   1 
ATOM 36   C CA  . ASN A 1 6   ? 102.137 104.997 135.314 1.00 54.33 ? 49  ASN A CA  1 
ATOM 37   C C   . ASN A 1 6   ? 103.454 104.668 134.625 1.00 61.17 ? 49  ASN A C   1 
ATOM 38   O O   . ASN A 1 6   ? 104.315 105.543 134.494 1.00 68.52 ? 49  ASN A O   1 
ATOM 39   C CB  . ASN A 1 6   ? 101.420 106.143 134.610 1.00 52.79 ? 49  ASN A CB  1 
ATOM 40   C CG  . ASN A 1 6   ? 100.944 105.766 133.222 1.00 56.72 ? 49  ASN A CG  1 
ATOM 41   O OD1 . ASN A 1 6   ? 100.659 104.601 132.947 1.00 60.20 ? 49  ASN A OD1 1 
ATOM 42   N ND2 . ASN A 1 6   ? 100.852 106.753 132.340 1.00 58.40 ? 49  ASN A ND2 1 
ATOM 43   N N   . GLY A 1 7   ? 103.607 103.420 134.190 1.00 50.80 ? 50  GLY A N   1 
ATOM 44   C CA  . GLY A 1 7   ? 104.798 103.006 133.480 1.00 44.60 ? 50  GLY A CA  1 
ATOM 45   C C   . GLY A 1 7   ? 106.040 102.846 134.327 1.00 53.37 ? 50  GLY A C   1 
ATOM 46   O O   . GLY A 1 7   ? 107.099 102.520 133.779 1.00 56.57 ? 50  GLY A O   1 
ATOM 47   N N   . VAL A 1 8   ? 105.953 103.063 135.640 1.00 46.72 ? 51  VAL A N   1 
ATOM 48   C CA  . VAL A 1 8   ? 107.089 102.916 136.539 1.00 44.84 ? 51  VAL A CA  1 
ATOM 49   C C   . VAL A 1 8   ? 106.645 102.203 137.807 1.00 44.52 ? 51  VAL A C   1 
ATOM 50   O O   . VAL A 1 8   ? 105.454 102.075 138.096 1.00 49.69 ? 51  VAL A O   1 
ATOM 51   C CB  . VAL A 1 8   ? 107.740 104.268 136.904 1.00 45.18 ? 51  VAL A CB  1 
ATOM 52   C CG1 . VAL A 1 8   ? 108.519 104.813 135.732 1.00 46.26 ? 51  VAL A CG1 1 
ATOM 53   C CG2 . VAL A 1 8   ? 106.681 105.259 137.351 1.00 44.38 ? 51  VAL A CG2 1 
ATOM 54   N N   . ARG A 1 9   ? 107.633 101.734 138.563 1.00 36.14 ? 52  ARG A N   1 
ATOM 55   C CA  . ARG A 1 9   ? 107.395 101.158 139.882 1.00 31.11 ? 52  ARG A CA  1 
ATOM 56   C C   . ARG A 1 9   ? 108.658 101.369 140.703 1.00 43.12 ? 52  ARG A C   1 
ATOM 57   O O   . ARG A 1 9   ? 109.691 100.754 140.422 1.00 53.41 ? 52  ARG A O   1 
ATOM 58   C CB  . ARG A 1 9   ? 107.036 99.680  139.791 1.00 39.78 ? 52  ARG A CB  1 
ATOM 59   C CG  . ARG A 1 9   ? 106.248 99.170  140.983 1.00 43.22 ? 52  ARG A CG  1 
ATOM 60   C CD  . ARG A 1 9   ? 106.250 97.654  141.043 1.00 47.65 ? 52  ARG A CD  1 
ATOM 61   N NE  . ARG A 1 9   ? 106.231 97.152  142.412 1.00 53.85 ? 52  ARG A NE  1 
ATOM 62   C CZ  . ARG A 1 9   ? 105.179 97.199  143.217 1.00 56.40 ? 52  ARG A CZ  1 
ATOM 63   N NH1 . ARG A 1 9   ? 104.026 97.712  142.821 1.00 52.95 ? 52  ARG A NH1 1 
ATOM 64   N NH2 . ARG A 1 9   ? 105.285 96.714  144.451 1.00 57.59 ? 52  ARG A NH2 1 
ATOM 65   N N   . VAL A 1 10  ? 108.575 102.235 141.708 1.00 45.43 ? 53  VAL A N   1 
ATOM 66   C CA  . VAL A 1 10  ? 109.703 102.572 142.568 1.00 41.57 ? 53  VAL A CA  1 
ATOM 67   C C   . VAL A 1 10  ? 109.516 101.857 143.897 1.00 45.59 ? 53  VAL A C   1 
ATOM 68   O O   . VAL A 1 10  ? 108.479 102.014 144.551 1.00 53.67 ? 53  VAL A O   1 
ATOM 69   C CB  . VAL A 1 10  ? 109.821 104.091 142.774 1.00 40.45 ? 53  VAL A CB  1 
ATOM 70   C CG1 . VAL A 1 10  ? 111.150 104.437 143.421 1.00 47.77 ? 53  VAL A CG1 1 
ATOM 71   C CG2 . VAL A 1 10  ? 109.656 104.820 141.453 1.00 43.27 ? 53  VAL A CG2 1 
ATOM 72   N N   . THR A 1 11  ? 110.517 101.078 144.296 1.00 42.46 ? 54  THR A N   1 
ATOM 73   C CA  . THR A 1 11  ? 110.468 100.297 145.523 1.00 43.52 ? 54  THR A CA  1 
ATOM 74   C C   . THR A 1 11  ? 111.613 100.709 146.437 1.00 48.47 ? 54  THR A C   1 
ATOM 75   O O   . THR A 1 11  ? 112.709 101.028 145.967 1.00 50.95 ? 54  THR A O   1 
ATOM 76   C CB  . THR A 1 11  ? 110.544 98.795  145.225 1.00 48.37 ? 54  THR A CB  1 
ATOM 77   O OG1 . THR A 1 11  ? 109.651 98.474  144.153 1.00 49.84 ? 54  THR A OG1 1 
ATOM 78   C CG2 . THR A 1 11  ? 110.154 97.983  146.450 1.00 48.08 ? 54  THR A CG2 1 
ATOM 79   N N   . TYR A 1 12  ? 111.352 100.706 147.742 1.00 54.71 ? 55  TYR A N   1 
ATOM 80   C CA  . TYR A 1 12  ? 112.330 101.083 148.751 1.00 50.48 ? 55  TYR A CA  1 
ATOM 81   C C   . TYR A 1 12  ? 112.497 99.950  149.753 1.00 57.77 ? 55  TYR A C   1 
ATOM 82   O O   . TYR A 1 12  ? 111.513 99.340  150.184 1.00 58.40 ? 55  TYR A O   1 
ATOM 83   C CB  . TYR A 1 12  ? 111.907 102.364 149.475 1.00 58.45 ? 55  TYR A CB  1 
ATOM 84   C CG  . TYR A 1 12  ? 112.717 102.673 150.712 1.00 57.74 ? 55  TYR A CG  1 
ATOM 85   C CD1 . TYR A 1 12  ? 114.073 102.951 150.627 1.00 52.60 ? 55  TYR A CD1 1 
ATOM 86   C CD2 . TYR A 1 12  ? 112.123 102.692 151.967 1.00 60.39 ? 55  TYR A CD2 1 
ATOM 87   C CE1 . TYR A 1 12  ? 114.814 103.235 151.755 1.00 52.74 ? 55  TYR A CE1 1 
ATOM 88   C CE2 . TYR A 1 12  ? 112.857 102.975 153.100 1.00 55.66 ? 55  TYR A CE2 1 
ATOM 89   C CZ  . TYR A 1 12  ? 114.201 103.245 152.988 1.00 55.87 ? 55  TYR A CZ  1 
ATOM 90   O OH  . TYR A 1 12  ? 114.936 103.528 154.115 1.00 61.94 ? 55  TYR A OH  1 
ATOM 91   N N   . ASP A 1 13  ? 113.745 99.674  150.122 1.00 64.13 ? 56  ASP A N   1 
ATOM 92   C CA  . ASP A 1 13  ? 114.078 98.619  151.072 1.00 59.39 ? 56  ASP A CA  1 
ATOM 93   C C   . ASP A 1 13  ? 114.527 99.260  152.378 1.00 55.87 ? 56  ASP A C   1 
ATOM 94   O O   . ASP A 1 13  ? 115.464 100.065 152.389 1.00 56.94 ? 56  ASP A O   1 
ATOM 95   C CB  . ASP A 1 13  ? 115.169 97.705  150.515 1.00 60.22 ? 56  ASP A CB  1 
ATOM 96   C CG  . ASP A 1 13  ? 115.597 96.639  151.503 1.00 66.84 ? 56  ASP A CG  1 
ATOM 97   O OD1 . ASP A 1 13  ? 114.789 95.730  151.786 1.00 67.13 ? 56  ASP A OD1 1 
ATOM 98   O OD2 . ASP A 1 13  ? 116.742 96.709  151.997 1.00 67.48 ? 56  ASP A OD2 1 
ATOM 99   N N   . ALA A 1 14  ? 113.859 98.900  153.475 1.00 53.90 ? 57  ALA A N   1 
ATOM 100  C CA  . ALA A 1 14  ? 114.172 99.508  154.764 1.00 56.65 ? 57  ALA A CA  1 
ATOM 101  C C   . ALA A 1 14  ? 115.519 99.035  155.296 1.00 58.66 ? 57  ALA A C   1 
ATOM 102  O O   . ALA A 1 14  ? 116.256 99.814  155.911 1.00 62.39 ? 57  ALA A O   1 
ATOM 103  C CB  . ALA A 1 14  ? 113.063 99.204  155.770 1.00 55.08 ? 57  ALA A CB  1 
ATOM 104  N N   . ASP A 1 15  ? 115.857 97.764  155.073 1.00 59.50 ? 58  ASP A N   1 
ATOM 105  C CA  . ASP A 1 15  ? 117.070 97.207  155.663 1.00 58.34 ? 58  ASP A CA  1 
ATOM 106  C C   . ASP A 1 15  ? 118.323 97.750  154.988 1.00 53.54 ? 58  ASP A C   1 
ATOM 107  O O   . ASP A 1 15  ? 119.287 98.130  155.662 1.00 52.58 ? 58  ASP A O   1 
ATOM 108  C CB  . ASP A 1 15  ? 117.034 95.681  155.586 1.00 58.51 ? 58  ASP A CB  1 
ATOM 109  C CG  . ASP A 1 15  ? 115.921 95.083  156.422 1.00 61.71 ? 58  ASP A CG  1 
ATOM 110  O OD1 . ASP A 1 15  ? 114.745 95.201  156.020 1.00 61.47 ? 58  ASP A OD1 1 
ATOM 111  O OD2 . ASP A 1 15  ? 116.222 94.497  157.483 1.00 63.16 ? 58  ASP A OD2 1 
ATOM 112  N N   . GLY A 1 16  ? 118.331 97.796  153.659 1.00 54.71 ? 59  GLY A N   1 
ATOM 113  C CA  . GLY A 1 16  ? 119.521 98.204  152.939 1.00 53.64 ? 59  GLY A CA  1 
ATOM 114  C C   . GLY A 1 16  ? 119.520 99.646  152.476 1.00 56.31 ? 59  GLY A C   1 
ATOM 115  O O   . GLY A 1 16  ? 120.548 100.148 152.013 1.00 60.47 ? 59  GLY A O   1 
ATOM 116  N N   . GLN A 1 17  ? 118.376 100.320 152.600 1.00 56.92 ? 60  GLN A N   1 
ATOM 117  C CA  . GLN A 1 17  ? 118.213 101.707 152.162 1.00 58.75 ? 60  GLN A CA  1 
ATOM 118  C C   . GLN A 1 17  ? 118.574 101.860 150.683 1.00 60.58 ? 60  GLN A C   1 
ATOM 119  O O   . GLN A 1 17  ? 119.463 102.624 150.303 1.00 61.24 ? 60  GLN A O   1 
ATOM 120  C CB  . GLN A 1 17  ? 119.039 102.658 153.035 1.00 57.52 ? 60  GLN A CB  1 
ATOM 121  C CG  . GLN A 1 17  ? 118.776 102.523 154.524 1.00 57.97 ? 60  GLN A CG  1 
ATOM 122  C CD  . GLN A 1 17  ? 119.850 103.181 155.364 1.00 61.22 ? 60  GLN A CD  1 
ATOM 123  O OE1 . GLN A 1 17  ? 120.447 104.178 154.958 1.00 60.40 ? 60  GLN A OE1 1 
ATOM 124  N NE2 . GLN A 1 17  ? 120.103 102.626 156.542 1.00 63.33 ? 60  GLN A NE2 1 
ATOM 125  N N   . THR A 1 18  ? 117.859 101.108 149.845 1.00 60.73 ? 61  THR A N   1 
ATOM 126  C CA  . THR A 1 18  ? 118.105 101.082 148.411 1.00 56.19 ? 61  THR A CA  1 
ATOM 127  C C   . THR A 1 18  ? 116.820 101.384 147.653 1.00 56.56 ? 61  THR A C   1 
ATOM 128  O O   . THR A 1 18  ? 115.716 101.128 148.141 1.00 55.86 ? 61  THR A O   1 
ATOM 129  C CB  . THR A 1 18  ? 118.656 99.723  147.947 1.00 58.64 ? 61  THR A CB  1 
ATOM 130  O OG1 . THR A 1 18  ? 117.569 98.825  147.695 1.00 61.82 ? 61  THR A OG1 1 
ATOM 131  C CG2 . THR A 1 18  ? 119.576 99.119  148.998 1.00 56.24 ? 61  THR A CG2 1 
ATOM 132  N N   . ILE A 1 19  ? 116.980 101.930 146.449 1.00 51.59 ? 62  ILE A N   1 
ATOM 133  C CA  . ILE A 1 19  ? 115.871 102.267 145.564 1.00 45.18 ? 62  ILE A CA  1 
ATOM 134  C C   . ILE A 1 19  ? 116.028 101.472 144.276 1.00 49.69 ? 62  ILE A C   1 
ATOM 135  O O   . ILE A 1 19  ? 117.102 101.481 143.664 1.00 55.28 ? 62  ILE A O   1 
ATOM 136  C CB  . ILE A 1 19  ? 115.821 103.778 145.269 1.00 48.13 ? 62  ILE A CB  1 
ATOM 137  C CG1 . ILE A 1 19  ? 115.188 104.539 146.434 1.00 50.04 ? 62  ILE A CG1 1 
ATOM 138  C CG2 . ILE A 1 19  ? 115.050 104.052 143.987 1.00 49.47 ? 62  ILE A CG2 1 
ATOM 139  C CD1 . ILE A 1 19  ? 113.914 103.927 146.944 1.00 50.35 ? 62  ILE A CD1 1 
ATOM 140  N N   . THR A 1 20  ? 114.962 100.786 143.867 1.00 50.43 ? 63  THR A N   1 
ATOM 141  C CA  . THR A 1 20  ? 114.939 100.015 142.631 1.00 48.73 ? 63  THR A CA  1 
ATOM 142  C C   . THR A 1 20  ? 113.863 100.563 141.704 1.00 48.70 ? 63  THR A C   1 
ATOM 143  O O   . THR A 1 20  ? 112.750 100.870 142.143 1.00 55.44 ? 63  THR A O   1 
ATOM 144  C CB  . THR A 1 20  ? 114.683 98.530  142.904 1.00 44.04 ? 63  THR A CB  1 
ATOM 145  O OG1 . THR A 1 20  ? 113.633 98.395  143.869 1.00 50.69 ? 63  THR A OG1 1 
ATOM 146  C CG2 . THR A 1 20  ? 115.938 97.862  143.435 1.00 45.70 ? 63  THR A CG2 1 
ATOM 147  N N   . LEU A 1 21  ? 114.197 100.682 140.421 1.00 36.99 ? 64  LEU A N   1 
ATOM 148  C CA  . LEU A 1 21  ? 113.300 101.238 139.417 1.00 28.61 ? 64  LEU A CA  1 
ATOM 149  C C   . LEU A 1 21  ? 112.862 100.155 138.441 1.00 36.60 ? 64  LEU A C   1 
ATOM 150  O O   . LEU A 1 21  ? 113.646 99.269  138.087 1.00 50.83 ? 64  LEU A O   1 
ATOM 151  C CB  . LEU A 1 21  ? 113.970 102.381 138.651 1.00 35.47 ? 64  LEU A CB  1 
ATOM 152  C CG  . LEU A 1 21  ? 114.192 103.694 139.403 1.00 40.54 ? 64  LEU A CG  1 
ATOM 153  C CD1 . LEU A 1 21  ? 114.604 104.796 138.446 1.00 40.99 ? 64  LEU A CD1 1 
ATOM 154  C CD2 . LEU A 1 21  ? 112.948 104.090 140.168 1.00 44.03 ? 64  LEU A CD2 1 
ATOM 155  N N   . TYR A 1 22  ? 111.607 100.234 138.007 1.00 37.66 ? 65  TYR A N   1 
ATOM 156  C CA  . TYR A 1 22  ? 111.032 99.299  137.053 1.00 31.70 ? 65  TYR A CA  1 
ATOM 157  C C   . TYR A 1 22  ? 110.338 100.070 135.938 1.00 41.76 ? 65  TYR A C   1 
ATOM 158  O O   . TYR A 1 22  ? 110.126 101.282 136.023 1.00 49.52 ? 65  TYR A O   1 
ATOM 159  C CB  . TYR A 1 22  ? 110.029 98.349  137.723 1.00 36.78 ? 65  TYR A CB  1 
ATOM 160  C CG  . TYR A 1 22  ? 110.638 97.350  138.677 1.00 37.89 ? 65  TYR A CG  1 
ATOM 161  C CD1 . TYR A 1 22  ? 111.056 96.105  138.234 1.00 36.48 ? 65  TYR A CD1 1 
ATOM 162  C CD2 . TYR A 1 22  ? 110.777 97.644  140.025 1.00 42.35 ? 65  TYR A CD2 1 
ATOM 163  C CE1 . TYR A 1 22  ? 111.605 95.186  139.104 1.00 36.10 ? 65  TYR A CE1 1 
ATOM 164  C CE2 . TYR A 1 22  ? 111.325 96.732  140.902 1.00 40.10 ? 65  TYR A CE2 1 
ATOM 165  C CZ  . TYR A 1 22  ? 111.737 95.505  140.436 1.00 34.14 ? 65  TYR A CZ  1 
ATOM 166  O OH  . TYR A 1 22  ? 112.284 94.593  141.307 1.00 41.80 ? 65  TYR A OH  1 
ATOM 167  N N   . ARG A 1 23  ? 109.982 99.344  134.881 1.00 36.91 ? 66  ARG A N   1 
ATOM 168  C CA  . ARG A 1 23  ? 109.189 99.877  133.784 1.00 33.05 ? 66  ARG A CA  1 
ATOM 169  C C   . ARG A 1 23  ? 108.189 98.817  133.352 1.00 40.80 ? 66  ARG A C   1 
ATOM 170  O O   . ARG A 1 23  ? 108.537 97.639  133.235 1.00 54.62 ? 66  ARG A O   1 
ATOM 171  C CB  . ARG A 1 23  ? 110.068 100.292 132.598 1.00 32.74 ? 66  ARG A CB  1 
ATOM 172  C CG  . ARG A 1 23  ? 109.418 100.090 131.245 1.00 40.75 ? 66  ARG A CG  1 
ATOM 173  C CD  . ARG A 1 23  ? 110.316 100.547 130.110 1.00 47.00 ? 66  ARG A CD  1 
ATOM 174  N NE  . ARG A 1 23  ? 111.106 99.456  129.552 1.00 42.87 ? 66  ARG A NE  1 
ATOM 175  C CZ  . ARG A 1 23  ? 110.640 98.552  128.702 1.00 37.79 ? 66  ARG A CZ  1 
ATOM 176  N NH1 . ARG A 1 23  ? 109.377 98.556  128.311 1.00 38.18 ? 66  ARG A NH1 1 
ATOM 177  N NH2 . ARG A 1 23  ? 111.462 97.618  128.233 1.00 39.97 ? 66  ARG A NH2 1 
ATOM 178  N N   . THR A 1 24  ? 106.948 99.236  133.120 1.00 43.47 ? 67  THR A N   1 
ATOM 179  C CA  . THR A 1 24  ? 105.874 98.310  132.791 1.00 42.45 ? 67  THR A CA  1 
ATOM 180  C C   . THR A 1 24  ? 105.774 98.126  131.282 1.00 48.02 ? 67  THR A C   1 
ATOM 181  O O   . THR A 1 24  ? 105.672 99.104  130.535 1.00 51.73 ? 67  THR A O   1 
ATOM 182  C CB  . THR A 1 24  ? 104.539 98.809  133.343 1.00 44.04 ? 67  THR A CB  1 
ATOM 183  O OG1 . THR A 1 24  ? 103.965 99.752  132.430 1.00 47.72 ? 67  THR A OG1 1 
ATOM 184  C CG2 . THR A 1 24  ? 104.738 99.482  134.689 1.00 51.97 ? 67  THR A CG2 1 
ATOM 185  N N   . GLU A 1 25  ? 105.808 96.870  130.840 1.00 59.90 ? 68  GLU A N   1 
ATOM 186  C CA  . GLU A 1 25  ? 105.478 96.522  129.467 1.00 59.67 ? 68  GLU A CA  1 
ATOM 187  C C   . GLU A 1 25  ? 104.575 95.298  129.491 1.00 61.20 ? 68  GLU A C   1 
ATOM 188  O O   . GLU A 1 25  ? 104.693 94.440  130.371 1.00 63.46 ? 68  GLU A O   1 
ATOM 189  C CB  . GLU A 1 25  ? 106.724 96.248  128.609 1.00 59.24 ? 68  GLU A CB  1 
ATOM 190  C CG  . GLU A 1 25  ? 107.159 94.793  128.562 1.00 61.06 ? 68  GLU A CG  1 
ATOM 191  C CD  . GLU A 1 25  ? 108.062 94.494  127.381 1.00 66.43 ? 68  GLU A CD  1 
ATOM 192  O OE1 . GLU A 1 25  ? 107.934 95.181  126.347 1.00 67.34 ? 68  GLU A OE1 1 
ATOM 193  O OE2 . GLU A 1 25  ? 108.882 93.559  127.477 1.00 63.06 ? 68  GLU A OE2 1 
ATOM 194  N N   . GLY A 1 26  ? 103.667 95.230  128.523 1.00 63.38 ? 69  GLY A N   1 
ATOM 195  C CA  . GLY A 1 26  ? 102.695 94.150  128.518 1.00 64.41 ? 69  GLY A CA  1 
ATOM 196  C C   . GLY A 1 26  ? 101.860 94.183  129.782 1.00 63.32 ? 69  GLY A C   1 
ATOM 197  O O   . GLY A 1 26  ? 101.327 95.225  130.176 1.00 62.44 ? 69  GLY A O   1 
ATOM 198  N N   . SER A 1 27  ? 101.743 93.027  130.432 1.00 65.03 ? 70  SER A N   1 
ATOM 199  C CA  . SER A 1 27  ? 101.057 92.915  131.711 1.00 65.63 ? 70  SER A CA  1 
ATOM 200  C C   . SER A 1 27  ? 102.023 92.778  132.881 1.00 65.13 ? 70  SER A C   1 
ATOM 201  O O   . SER A 1 27  ? 101.581 92.577  134.016 1.00 64.81 ? 70  SER A O   1 
ATOM 202  C CB  . SER A 1 27  ? 100.091 91.729  131.691 1.00 66.13 ? 70  SER A CB  1 
ATOM 203  O OG  . SER A 1 27  ? 100.781 90.513  131.462 1.00 67.34 ? 70  SER A OG  1 
ATOM 204  N N   . GLY A 1 28  ? 103.326 92.883  132.632 1.00 56.67 ? 71  GLY A N   1 
ATOM 205  C CA  . GLY A 1 28  ? 104.313 92.712  133.679 1.00 52.36 ? 71  GLY A CA  1 
ATOM 206  C C   . GLY A 1 28  ? 105.258 93.885  133.823 1.00 52.52 ? 71  GLY A C   1 
ATOM 207  O O   . GLY A 1 28  ? 104.975 94.985  133.339 1.00 57.72 ? 71  GLY A O   1 
ATOM 208  N N   . LEU A 1 29  ? 106.389 93.661  134.488 1.00 40.38 ? 72  LEU A N   1 
ATOM 209  C CA  . LEU A 1 29  ? 107.365 94.705  134.756 1.00 37.95 ? 72  LEU A CA  1 
ATOM 210  C C   . LEU A 1 29  ? 108.745 94.237  134.321 1.00 38.00 ? 72  LEU A C   1 
ATOM 211  O O   . LEU A 1 29  ? 109.022 93.036  134.265 1.00 48.71 ? 72  LEU A O   1 
ATOM 212  C CB  . LEU A 1 29  ? 107.396 95.075  136.242 1.00 44.73 ? 72  LEU A CB  1 
ATOM 213  C CG  . LEU A 1 29  ? 106.048 95.157  136.955 1.00 49.67 ? 72  LEU A CG  1 
ATOM 214  C CD1 . LEU A 1 29  ? 106.247 95.164  138.458 1.00 46.10 ? 72  LEU A CD1 1 
ATOM 215  C CD2 . LEU A 1 29  ? 105.276 96.385  136.509 1.00 48.34 ? 72  LEU A CD2 1 
ATOM 216  N N   . ILE A 1 30  ? 109.611 95.199  134.015 1.00 38.32 ? 73  ILE A N   1 
ATOM 217  C CA  . ILE A 1 30  ? 110.991 94.928  133.635 1.00 40.51 ? 73  ILE A CA  1 
ATOM 218  C C   . ILE A 1 30  ? 111.905 95.722  134.555 1.00 49.15 ? 73  ILE A C   1 
ATOM 219  O O   . ILE A 1 30  ? 111.722 96.933  134.724 1.00 50.68 ? 73  ILE A O   1 
ATOM 220  C CB  . ILE A 1 30  ? 111.265 95.287  132.163 1.00 42.27 ? 73  ILE A CB  1 
ATOM 221  C CG1 . ILE A 1 30  ? 110.474 94.372  131.233 1.00 48.27 ? 73  ILE A CG1 1 
ATOM 222  C CG2 . ILE A 1 30  ? 112.746 95.177  131.854 1.00 45.78 ? 73  ILE A CG2 1 
ATOM 223  C CD1 . ILE A 1 30  ? 110.765 94.613  129.774 1.00 49.03 ? 73  ILE A CD1 1 
ATOM 224  N N   . GLN A 1 31  ? 112.882 95.043  135.150 1.00 47.59 ? 74  GLN A N   1 
ATOM 225  C CA  . GLN A 1 31  ? 113.857 95.719  135.993 1.00 37.32 ? 74  GLN A CA  1 
ATOM 226  C C   . GLN A 1 31  ? 114.724 96.642  135.150 1.00 34.49 ? 74  GLN A C   1 
ATOM 227  O O   . GLN A 1 31  ? 115.201 96.257  134.079 1.00 37.85 ? 74  GLN A O   1 
ATOM 228  C CB  . GLN A 1 31  ? 114.724 94.698  136.724 1.00 33.46 ? 74  GLN A CB  1 
ATOM 229  C CG  . GLN A 1 31  ? 115.604 95.291  137.805 1.00 34.42 ? 74  GLN A CG  1 
ATOM 230  C CD  . GLN A 1 31  ? 115.820 94.340  138.962 1.00 38.01 ? 74  GLN A CD  1 
ATOM 231  O OE1 . GLN A 1 31  ? 114.984 93.481  139.238 1.00 40.37 ? 74  GLN A OE1 1 
ATOM 232  N NE2 . GLN A 1 31  ? 116.946 94.488  139.648 1.00 42.53 ? 74  GLN A NE2 1 
ATOM 233  N N   . MET A 1 32  ? 114.928 97.866  135.634 1.00 33.60 ? 75  MET A N   1 
ATOM 234  C CA  . MET A 1 32  ? 115.737 98.846  134.929 1.00 36.62 ? 75  MET A CA  1 
ATOM 235  C C   . MET A 1 32  ? 116.879 99.418  135.752 1.00 37.61 ? 75  MET A C   1 
ATOM 236  O O   . MET A 1 32  ? 117.698 100.158 135.198 1.00 40.34 ? 75  MET A O   1 
ATOM 237  C CB  . MET A 1 32  ? 114.864 100.006 134.425 1.00 40.94 ? 75  MET A CB  1 
ATOM 238  C CG  . MET A 1 32  ? 115.251 100.526 133.048 1.00 44.68 ? 75  MET A CG  1 
ATOM 239  S SD  . MET A 1 32  ? 114.751 99.465  131.679 1.00 61.05 ? 75  MET A SD  1 
ATOM 240  C CE  . MET A 1 32  ? 113.271 98.712  132.341 1.00 47.06 ? 75  MET A CE  1 
ATOM 241  N N   . SER A 1 33  ? 116.968 99.105  137.041 1.00 40.53 ? 76  SER A N   1 
ATOM 242  C CA  . SER A 1 33  ? 118.045 99.624  137.867 1.00 41.71 ? 76  SER A CA  1 
ATOM 243  C C   . SER A 1 33  ? 118.303 98.676  139.027 1.00 48.79 ? 76  SER A C   1 
ATOM 244  O O   . SER A 1 33  ? 117.365 98.186  139.660 1.00 52.03 ? 76  SER A O   1 
ATOM 245  C CB  . SER A 1 33  ? 117.722 101.025 138.395 1.00 42.39 ? 76  SER A CB  1 
ATOM 246  O OG  . SER A 1 33  ? 116.785 100.965 139.456 1.00 52.93 ? 76  SER A OG  1 
ATOM 247  N N   . LYS A 1 34  ? 119.580 98.424  139.292 1.00 43.87 ? 77  LYS A N   1 
ATOM 248  C CA  . LYS A 1 34  ? 119.975 97.662  140.458 1.00 34.41 ? 77  LYS A CA  1 
ATOM 249  C C   . LYS A 1 34  ? 119.775 98.504  141.714 1.00 39.71 ? 77  LYS A C   1 
ATOM 250  O O   . LYS A 1 34  ? 119.651 99.728  141.634 1.00 46.04 ? 77  LYS A O   1 
ATOM 251  C CB  . LYS A 1 34  ? 121.433 97.227  140.330 1.00 43.97 ? 77  LYS A CB  1 
ATOM 252  C CG  . LYS A 1 34  ? 121.748 96.504  139.037 1.00 43.78 ? 77  LYS A CG  1 
ATOM 253  C CD  . LYS A 1 34  ? 123.125 96.873  138.522 1.00 44.40 ? 77  LYS A CD  1 
ATOM 254  C CE  . LYS A 1 34  ? 124.171 95.884  138.995 1.00 45.69 ? 77  LYS A CE  1 
ATOM 255  N NZ  . LYS A 1 34  ? 125.313 95.800  138.047 1.00 49.98 ? 77  LYS A NZ  1 
ATOM 256  N N   . PRO A 1 35  ? 119.709 97.870  142.885 1.00 39.14 ? 78  PRO A N   1 
ATOM 257  C CA  . PRO A 1 35  ? 119.559 98.637  144.127 1.00 44.05 ? 78  PRO A CA  1 
ATOM 258  C C   . PRO A 1 35  ? 120.652 99.686  144.275 1.00 46.62 ? 78  PRO A C   1 
ATOM 259  O O   . PRO A 1 35  ? 121.841 99.399  144.123 1.00 49.26 ? 78  PRO A O   1 
ATOM 260  C CB  . PRO A 1 35  ? 119.653 97.562  145.212 1.00 47.69 ? 78  PRO A CB  1 
ATOM 261  C CG  . PRO A 1 35  ? 119.163 96.331  144.549 1.00 42.48 ? 78  PRO A CG  1 
ATOM 262  C CD  . PRO A 1 35  ? 119.626 96.418  143.125 1.00 42.06 ? 78  PRO A CD  1 
ATOM 263  N N   . SER A 1 36  ? 120.237 100.913 144.573 1.00 50.42 ? 79  SER A N   1 
ATOM 264  C CA  . SER A 1 36  ? 121.135 102.052 144.644 1.00 50.69 ? 79  SER A CA  1 
ATOM 265  C C   . SER A 1 36  ? 120.860 102.861 145.902 1.00 55.44 ? 79  SER A C   1 
ATOM 266  O O   . SER A 1 36  ? 119.722 102.908 146.378 1.00 54.88 ? 79  SER A O   1 
ATOM 267  C CB  . SER A 1 36  ? 120.975 102.951 143.409 1.00 45.86 ? 79  SER A CB  1 
ATOM 268  O OG  . SER A 1 36  ? 120.974 102.185 142.218 1.00 48.93 ? 79  SER A OG  1 
ATOM 269  N N   . PRO A 1 37  ? 121.879 103.514 146.456 1.00 53.12 ? 80  PRO A N   1 
ATOM 270  C CA  . PRO A 1 37  ? 121.679 104.301 147.677 1.00 45.24 ? 80  PRO A CA  1 
ATOM 271  C C   . PRO A 1 37  ? 120.932 105.594 147.388 1.00 55.32 ? 80  PRO A C   1 
ATOM 272  O O   . PRO A 1 37  ? 120.797 106.037 146.246 1.00 56.84 ? 80  PRO A O   1 
ATOM 273  C CB  . PRO A 1 37  ? 123.104 104.571 148.159 1.00 52.78 ? 80  PRO A CB  1 
ATOM 274  C CG  . PRO A 1 37  ? 123.915 104.567 146.911 1.00 52.62 ? 80  PRO A CG  1 
ATOM 275  C CD  . PRO A 1 37  ? 123.278 103.554 145.997 1.00 50.27 ? 80  PRO A CD  1 
ATOM 276  N N   . LEU A 1 38  ? 120.439 106.207 148.466 1.00 56.61 ? 81  LEU A N   1 
ATOM 277  C CA  . LEU A 1 38  ? 119.638 107.418 148.333 1.00 53.09 ? 81  LEU A CA  1 
ATOM 278  C C   . LEU A 1 38  ? 120.486 108.645 148.019 1.00 53.57 ? 81  LEU A C   1 
ATOM 279  O O   . LEU A 1 38  ? 120.022 109.547 147.313 1.00 59.79 ? 81  LEU A O   1 
ATOM 280  C CB  . LEU A 1 38  ? 118.828 107.653 149.608 1.00 51.66 ? 81  LEU A CB  1 
ATOM 281  C CG  . LEU A 1 38  ? 117.377 107.168 149.600 1.00 51.89 ? 81  LEU A CG  1 
ATOM 282  C CD1 . LEU A 1 38  ? 117.295 105.693 149.249 1.00 55.97 ? 81  LEU A CD1 1 
ATOM 283  C CD2 . LEU A 1 38  ? 116.716 107.436 150.940 1.00 52.89 ? 81  LEU A CD2 1 
ATOM 284  N N   . GLY A 1 39  ? 121.707 108.702 148.522 1.00 50.46 ? 82  GLY A N   1 
ATOM 285  C CA  . GLY A 1 39  ? 122.563 109.847 148.292 1.00 48.47 ? 82  GLY A CA  1 
ATOM 286  C C   . GLY A 1 39  ? 122.524 110.830 149.447 1.00 52.40 ? 82  GLY A C   1 
ATOM 287  O O   . GLY A 1 39  ? 121.526 110.953 150.166 1.00 56.85 ? 82  GLY A O   1 
ATOM 288  N N   . GLY A 1 40  ? 123.629 111.549 149.629 1.00 55.73 ? 83  GLY A N   1 
ATOM 289  C CA  . GLY A 1 40  ? 123.750 112.481 150.724 1.00 60.16 ? 83  GLY A CA  1 
ATOM 290  C C   . GLY A 1 40  ? 124.711 113.618 150.439 1.00 59.92 ? 83  GLY A C   1 
ATOM 291  O O   . GLY A 1 40  ? 125.253 113.747 149.337 1.00 63.89 ? 83  GLY A O   1 
ATOM 292  N N   . PRO A 1 41  ? 124.936 114.469 151.434 1.00 43.90 ? 84  PRO A N   1 
ATOM 293  C CA  . PRO A 1 41  ? 125.827 115.614 151.247 1.00 38.75 ? 84  PRO A CA  1 
ATOM 294  C C   . PRO A 1 41  ? 127.291 115.221 151.355 1.00 43.66 ? 84  PRO A C   1 
ATOM 295  O O   . PRO A 1 41  ? 127.647 114.141 151.829 1.00 55.79 ? 84  PRO A O   1 
ATOM 296  C CB  . PRO A 1 41  ? 125.429 116.554 152.389 1.00 43.90 ? 84  PRO A CB  1 
ATOM 297  C CG  . PRO A 1 41  ? 124.950 115.642 153.456 1.00 40.77 ? 84  PRO A CG  1 
ATOM 298  C CD  . PRO A 1 41  ? 124.329 114.452 152.776 1.00 44.37 ? 84  PRO A CD  1 
ATOM 299  N N   . VAL A 1 42  ? 128.145 116.131 150.902 1.00 47.31 ? 85  VAL A N   1 
ATOM 300  C CA  . VAL A 1 42  ? 129.591 115.969 150.982 1.00 49.88 ? 85  VAL A CA  1 
ATOM 301  C C   . VAL A 1 42  ? 130.091 116.879 152.095 1.00 54.65 ? 85  VAL A C   1 
ATOM 302  O O   . VAL A 1 42  ? 130.111 118.106 151.947 1.00 59.97 ? 85  VAL A O   1 
ATOM 303  C CB  . VAL A 1 42  ? 130.273 116.290 149.646 1.00 53.84 ? 85  VAL A CB  1 
ATOM 304  C CG1 . VAL A 1 42  ? 131.784 116.339 149.818 1.00 54.86 ? 85  VAL A CG1 1 
ATOM 305  C CG2 . VAL A 1 42  ? 129.886 115.265 148.594 1.00 52.57 ? 85  VAL A CG2 1 
ATOM 306  N N   . VAL A 1 43  ? 130.494 116.285 153.215 1.00 55.94 ? 86  VAL A N   1 
ATOM 307  C CA  . VAL A 1 43  ? 130.979 117.022 154.376 1.00 51.79 ? 86  VAL A CA  1 
ATOM 308  C C   . VAL A 1 43  ? 132.429 116.628 154.611 1.00 55.62 ? 86  VAL A C   1 
ATOM 309  O O   . VAL A 1 43  ? 132.737 115.441 154.778 1.00 61.65 ? 86  VAL A O   1 
ATOM 310  C CB  . VAL A 1 43  ? 130.129 116.748 155.625 1.00 53.48 ? 86  VAL A CB  1 
ATOM 311  C CG1 . VAL A 1 43  ? 130.500 117.712 156.738 1.00 57.80 ? 86  VAL A CG1 1 
ATOM 312  C CG2 . VAL A 1 43  ? 128.651 116.855 155.296 1.00 55.45 ? 86  VAL A CG2 1 
ATOM 313  N N   . GLY A 1 44  ? 133.315 117.620 154.631 1.00 57.93 ? 87  GLY A N   1 
ATOM 314  C CA  . GLY A 1 44  ? 134.727 117.359 154.848 1.00 60.51 ? 87  GLY A CA  1 
ATOM 315  C C   . GLY A 1 44  ? 135.384 116.550 153.754 1.00 65.61 ? 87  GLY A C   1 
ATOM 316  O O   . GLY A 1 44  ? 136.297 115.765 154.033 1.00 66.64 ? 87  GLY A O   1 
ATOM 317  N N   . GLY A 1 45  ? 134.945 116.719 152.509 1.00 70.90 ? 88  GLY A N   1 
ATOM 318  C CA  . GLY A 1 45  ? 135.531 116.020 151.386 1.00 70.79 ? 88  GLY A CA  1 
ATOM 319  C C   . GLY A 1 45  ? 135.045 114.604 151.180 1.00 70.71 ? 88  GLY A C   1 
ATOM 320  O O   . GLY A 1 45  ? 135.463 113.962 150.208 1.00 71.12 ? 88  GLY A O   1 
ATOM 321  N N   . GLN A 1 46  ? 134.179 114.095 152.052 1.00 71.28 ? 89  GLN A N   1 
ATOM 322  C CA  . GLN A 1 46  ? 133.658 112.741 151.943 1.00 71.61 ? 89  GLN A CA  1 
ATOM 323  C C   . GLN A 1 46  ? 132.152 112.755 152.150 1.00 71.84 ? 89  GLN A C   1 
ATOM 324  O O   . GLN A 1 46  ? 131.646 113.446 153.039 1.00 74.58 ? 89  GLN A O   1 
ATOM 325  C CB  . GLN A 1 46  ? 134.317 111.806 152.964 1.00 68.45 ? 89  GLN A CB  1 
ATOM 326  C CG  . GLN A 1 46  ? 135.731 111.389 152.603 1.00 71.40 ? 89  GLN A CG  1 
ATOM 327  C CD  . GLN A 1 46  ? 135.771 110.102 151.804 1.00 76.10 ? 89  GLN A CD  1 
ATOM 328  O OE1 . GLN A 1 46  ? 135.171 109.099 152.190 1.00 78.22 ? 89  GLN A OE1 1 
ATOM 329  N NE2 . GLN A 1 46  ? 136.480 110.124 150.682 1.00 75.09 ? 89  GLN A NE2 1 
ATOM 330  N N   . GLU A 1 47  ? 131.442 111.992 151.326 1.00 61.91 ? 90  GLU A N   1 
ATOM 331  C CA  . GLU A 1 47  ? 130.000 111.873 151.475 1.00 57.04 ? 90  GLU A CA  1 
ATOM 332  C C   . GLU A 1 47  ? 129.665 111.152 152.773 1.00 58.13 ? 90  GLU A C   1 
ATOM 333  O O   . GLU A 1 47  ? 130.323 110.177 153.147 1.00 64.17 ? 90  GLU A O   1 
ATOM 334  C CB  . GLU A 1 47  ? 129.405 111.128 150.280 1.00 62.34 ? 90  GLU A CB  1 
ATOM 335  C CG  . GLU A 1 47  ? 128.046 110.499 150.536 1.00 63.99 ? 90  GLU A CG  1 
ATOM 336  C CD  . GLU A 1 47  ? 127.497 109.784 149.317 1.00 66.81 ? 90  GLU A CD  1 
ATOM 337  O OE1 . GLU A 1 47  ? 128.303 109.350 148.467 1.00 67.29 ? 90  GLU A OE1 1 
ATOM 338  O OE2 . GLU A 1 47  ? 126.260 109.655 149.209 1.00 66.84 ? 90  GLU A OE2 1 
ATOM 339  N N   . VAL A 1 48  ? 128.641 111.641 153.469 1.00 56.77 ? 91  VAL A N   1 
ATOM 340  C CA  . VAL A 1 48  ? 128.244 111.041 154.737 1.00 63.40 ? 91  VAL A CA  1 
ATOM 341  C C   . VAL A 1 48  ? 127.570 109.703 154.462 1.00 66.37 ? 91  VAL A C   1 
ATOM 342  O O   . VAL A 1 48  ? 126.595 109.626 153.706 1.00 66.03 ? 91  VAL A O   1 
ATOM 343  C CB  . VAL A 1 48  ? 127.321 111.980 155.523 1.00 65.19 ? 91  VAL A CB  1 
ATOM 344  C CG1 . VAL A 1 48  ? 126.720 111.255 156.716 1.00 64.46 ? 91  VAL A CG1 1 
ATOM 345  C CG2 . VAL A 1 48  ? 128.082 113.216 155.973 1.00 65.51 ? 91  VAL A CG2 1 
ATOM 346  N N   . GLN A 1 49  ? 128.089 108.643 155.077 1.00 69.54 ? 92  GLN A N   1 
ATOM 347  C CA  . GLN A 1 49  ? 127.576 107.289 154.910 1.00 64.66 ? 92  GLN A CA  1 
ATOM 348  C C   . GLN A 1 49  ? 127.177 106.688 156.251 1.00 64.38 ? 92  GLN A C   1 
ATOM 349  O O   . GLN A 1 49  ? 127.386 105.501 156.509 1.00 69.45 ? 92  GLN A O   1 
ATOM 350  C CB  . GLN A 1 49  ? 128.600 106.399 154.209 1.00 64.99 ? 92  GLN A CB  1 
ATOM 351  C CG  . GLN A 1 49  ? 129.366 107.085 153.092 1.00 66.95 ? 92  GLN A CG  1 
ATOM 352  C CD  . GLN A 1 49  ? 128.855 106.706 151.717 1.00 70.92 ? 92  GLN A CD  1 
ATOM 353  O OE1 . GLN A 1 49  ? 127.745 107.073 151.332 1.00 72.34 ? 92  GLN A OE1 1 
ATOM 354  N NE2 . GLN A 1 49  ? 129.664 105.967 150.968 1.00 69.57 ? 92  GLN A NE2 1 
ATOM 355  N N   . ASP A 1 50  ? 126.596 107.507 157.125 1.00 64.47 ? 93  ASP A N   1 
ATOM 356  C CA  . ASP A 1 50  ? 126.158 107.058 158.440 1.00 66.78 ? 93  ASP A CA  1 
ATOM 357  C C   . ASP A 1 50  ? 124.656 107.213 158.638 1.00 70.51 ? 93  ASP A C   1 
ATOM 358  O O   . ASP A 1 50  ? 124.181 107.134 159.777 1.00 72.70 ? 93  ASP A O   1 
ATOM 359  C CB  . ASP A 1 50  ? 126.908 107.818 159.538 1.00 69.40 ? 93  ASP A CB  1 
ATOM 360  C CG  . ASP A 1 50  ? 128.031 107.003 160.147 1.00 73.66 ? 93  ASP A CG  1 
ATOM 361  O OD1 . ASP A 1 50  ? 127.859 105.777 160.308 1.00 71.81 ? 93  ASP A OD1 1 
ATOM 362  O OD2 . ASP A 1 50  ? 129.088 107.589 160.464 1.00 73.99 ? 93  ASP A OD2 1 
ATOM 363  N N   . PHE A 1 51  ? 123.899 107.431 157.567 1.00 56.67 ? 94  PHE A N   1 
ATOM 364  C CA  . PHE A 1 51  ? 122.472 107.685 157.700 1.00 51.28 ? 94  PHE A CA  1 
ATOM 365  C C   . PHE A 1 51  ? 121.735 106.417 158.108 1.00 51.82 ? 94  PHE A C   1 
ATOM 366  O O   . PHE A 1 51  ? 122.000 105.328 157.591 1.00 59.30 ? 94  PHE A O   1 
ATOM 367  C CB  . PHE A 1 51  ? 121.910 108.230 156.389 1.00 53.75 ? 94  PHE A CB  1 
ATOM 368  C CG  . PHE A 1 51  ? 122.260 109.669 156.135 1.00 57.35 ? 94  PHE A CG  1 
ATOM 369  C CD1 . PHE A 1 51  ? 121.621 110.684 156.824 1.00 55.50 ? 94  PHE A CD1 1 
ATOM 370  C CD2 . PHE A 1 51  ? 123.232 110.005 155.210 1.00 56.69 ? 94  PHE A CD2 1 
ATOM 371  C CE1 . PHE A 1 51  ? 121.943 112.004 156.594 1.00 51.98 ? 94  PHE A CE1 1 
ATOM 372  C CE2 . PHE A 1 51  ? 123.557 111.324 154.976 1.00 53.18 ? 94  PHE A CE2 1 
ATOM 373  C CZ  . PHE A 1 51  ? 122.913 112.324 155.669 1.00 53.02 ? 94  PHE A CZ  1 
ATOM 374  N N   . SER A 1 52  ? 120.804 106.565 159.046 1.00 47.43 ? 95  SER A N   1 
ATOM 375  C CA  . SER A 1 52  ? 120.032 105.453 159.577 1.00 47.84 ? 95  SER A CA  1 
ATOM 376  C C   . SER A 1 52  ? 118.550 105.696 159.338 1.00 49.72 ? 95  SER A C   1 
ATOM 377  O O   . SER A 1 52  ? 118.047 106.799 159.569 1.00 53.08 ? 95  SER A O   1 
ATOM 378  C CB  . SER A 1 52  ? 120.299 105.259 161.072 1.00 52.99 ? 95  SER A CB  1 
ATOM 379  O OG  . SER A 1 52  ? 119.813 106.358 161.823 1.00 59.84 ? 95  SER A OG  1 
ATOM 380  N N   . HIS A 1 53  ? 117.858 104.659 158.879 1.00 50.27 ? 96  HIS A N   1 
ATOM 381  C CA  . HIS A 1 53  ? 116.438 104.769 158.580 1.00 48.27 ? 96  HIS A CA  1 
ATOM 382  C C   . HIS A 1 53  ? 115.636 104.998 159.855 1.00 50.95 ? 96  HIS A C   1 
ATOM 383  O O   . HIS A 1 53  ? 115.870 104.353 160.880 1.00 57.33 ? 96  HIS A O   1 
ATOM 384  C CB  . HIS A 1 53  ? 115.961 103.505 157.864 1.00 49.65 ? 96  HIS A CB  1 
ATOM 385  C CG  . HIS A 1 53  ? 114.473 103.364 157.799 1.00 48.48 ? 96  HIS A CG  1 
ATOM 386  N ND1 . HIS A 1 53  ? 113.733 103.782 156.715 1.00 54.33 ? 96  HIS A ND1 1 
ATOM 387  C CD2 . HIS A 1 53  ? 113.588 102.830 158.674 1.00 51.42 ? 96  HIS A CD2 1 
ATOM 388  C CE1 . HIS A 1 53  ? 112.455 103.524 156.930 1.00 56.86 ? 96  HIS A CE1 1 
ATOM 389  N NE2 . HIS A 1 53  ? 112.341 102.946 158.112 1.00 57.33 ? 96  HIS A NE2 1 
ATOM 390  N N   . ILE A 1 54  ? 114.684 105.927 159.787 1.00 52.63 ? 97  ILE A N   1 
ATOM 391  C CA  . ILE A 1 54  ? 113.796 106.237 160.906 1.00 50.65 ? 97  ILE A CA  1 
ATOM 392  C C   . ILE A 1 54  ? 112.389 105.705 160.656 1.00 58.12 ? 97  ILE A C   1 
ATOM 393  O O   . ILE A 1 54  ? 111.898 104.851 161.396 1.00 64.00 ? 97  ILE A O   1 
ATOM 394  C CB  . ILE A 1 54  ? 113.774 107.754 161.198 1.00 51.93 ? 97  ILE A CB  1 
ATOM 395  C CG1 . ILE A 1 54  ? 115.186 108.282 161.437 1.00 54.23 ? 97  ILE A CG1 1 
ATOM 396  C CG2 . ILE A 1 54  ? 112.885 108.052 162.393 1.00 56.33 ? 97  ILE A CG2 1 
ATOM 397  C CD1 . ILE A 1 54  ? 115.286 109.782 161.316 1.00 56.89 ? 97  ILE A CD1 1 
ATOM 398  N N   . SER A 1 55  ? 111.725 106.198 159.613 1.00 60.67 ? 98  SER A N   1 
ATOM 399  C CA  . SER A 1 55  ? 110.376 105.758 159.293 1.00 60.52 ? 98  SER A CA  1 
ATOM 400  C C   . SER A 1 55  ? 110.093 106.063 157.830 1.00 64.43 ? 98  SER A C   1 
ATOM 401  O O   . SER A 1 55  ? 110.743 106.912 157.216 1.00 66.30 ? 98  SER A O   1 
ATOM 402  C CB  . SER A 1 55  ? 109.336 106.430 160.194 1.00 59.56 ? 98  SER A CB  1 
ATOM 403  O OG  . SER A 1 55  ? 109.504 107.837 160.203 1.00 64.05 ? 98  SER A OG  1 
ATOM 404  N N   . CYS A 1 56  ? 109.109 105.354 157.282 1.00 70.69 ? 99  CYS A N   1 
ATOM 405  C CA  . CYS A 1 56  ? 108.676 105.551 155.906 1.00 68.33 ? 99  CYS A CA  1 
ATOM 406  C C   . CYS A 1 56  ? 107.157 105.520 155.859 1.00 69.99 ? 99  CYS A C   1 
ATOM 407  O O   . CYS A 1 56  ? 106.540 104.569 156.347 1.00 72.62 ? 99  CYS A O   1 
ATOM 408  C CB  . CYS A 1 56  ? 109.262 104.479 154.979 1.00 67.15 ? 99  CYS A CB  1 
ATOM 409  S SG  . CYS A 1 56  ? 108.785 104.640 153.246 1.00 68.88 ? 99  CYS A SG  1 
ATOM 410  N N   . ASP A 1 57  ? 106.562 106.556 155.275 1.00 75.53 ? 100 ASP A N   1 
ATOM 411  C CA  . ASP A 1 57  ? 105.116 106.674 155.155 1.00 75.56 ? 100 ASP A CA  1 
ATOM 412  C C   . ASP A 1 57  ? 104.739 106.812 153.688 1.00 75.98 ? 100 ASP A C   1 
ATOM 413  O O   . ASP A 1 57  ? 105.378 107.560 152.942 1.00 73.54 ? 100 ASP A O   1 
ATOM 414  C CB  . ASP A 1 57  ? 104.590 107.876 155.946 1.00 75.52 ? 100 ASP A CB  1 
ATOM 415  C CG  . ASP A 1 57  ? 104.894 107.775 157.428 1.00 76.75 ? 100 ASP A CG  1 
ATOM 416  O OD1 . ASP A 1 57  ? 104.956 106.641 157.948 1.00 75.41 ? 100 ASP A OD1 1 
ATOM 417  O OD2 . ASP A 1 57  ? 105.070 108.830 158.074 1.00 76.63 ? 100 ASP A OD2 1 
ATOM 418  N N   . VAL A 1 58  ? 103.696 106.093 153.280 1.00 78.76 ? 101 VAL A N   1 
ATOM 419  C CA  . VAL A 1 58  ? 103.248 106.053 151.893 1.00 75.56 ? 101 VAL A CA  1 
ATOM 420  C C   . VAL A 1 58  ? 101.812 106.552 151.831 1.00 77.08 ? 101 VAL A C   1 
ATOM 421  O O   . VAL A 1 58  ? 100.959 106.102 152.605 1.00 76.39 ? 101 VAL A O   1 
ATOM 422  C CB  . VAL A 1 58  ? 103.357 104.636 151.300 1.00 74.18 ? 101 VAL A CB  1 
ATOM 423  C CG1 . VAL A 1 58  ? 103.047 104.658 149.814 1.00 73.31 ? 101 VAL A CG1 1 
ATOM 424  C CG2 . VAL A 1 58  ? 104.740 104.058 151.553 1.00 76.27 ? 101 VAL A CG2 1 
ATOM 425  N N   . GLU A 1 59  ? 101.550 107.480 150.915 1.00 80.19 ? 102 GLU A N   1 
ATOM 426  C CA  . GLU A 1 59  ? 100.221 108.038 150.701 1.00 76.77 ? 102 GLU A CA  1 
ATOM 427  C C   . GLU A 1 59  ? 99.731  107.637 149.316 1.00 79.22 ? 102 GLU A C   1 
ATOM 428  O O   . GLU A 1 59  ? 100.426 107.861 148.319 1.00 78.06 ? 102 GLU A O   1 
ATOM 429  C CB  . GLU A 1 59  ? 100.241 109.560 150.846 1.00 78.05 ? 102 GLU A CB  1 
ATOM 430  C CG  . GLU A 1 59  ? 100.766 110.049 152.186 1.00 81.06 ? 102 GLU A CG  1 
ATOM 431  C CD  . GLU A 1 59  ? 101.095 111.529 152.177 1.00 83.17 ? 102 GLU A CD  1 
ATOM 432  O OE1 . GLU A 1 59  ? 101.066 112.139 151.087 1.00 80.39 ? 102 GLU A OE1 1 
ATOM 433  O OE2 . GLU A 1 59  ? 101.382 112.083 153.259 1.00 84.23 ? 102 GLU A OE2 1 
ATOM 434  N N   . GLN A 1 60  ? 98.533  107.055 149.258 1.00 80.87 ? 103 GLN A N   1 
ATOM 435  C CA  . GLN A 1 60  ? 98.054  106.396 148.048 1.00 77.04 ? 103 GLN A CA  1 
ATOM 436  C C   . GLN A 1 60  ? 97.384  107.336 147.056 1.00 76.36 ? 103 GLN A C   1 
ATOM 437  O O   . GLN A 1 60  ? 97.352  107.031 145.858 1.00 77.91 ? 103 GLN A O   1 
ATOM 438  C CB  . GLN A 1 60  ? 97.076  105.276 148.416 1.00 76.19 ? 103 GLN A CB  1 
ATOM 439  C CG  . GLN A 1 60  ? 97.701  104.137 149.204 1.00 78.93 ? 103 GLN A CG  1 
ATOM 440  C CD  . GLN A 1 60  ? 98.612  103.270 148.359 1.00 79.46 ? 103 GLN A CD  1 
ATOM 441  O OE1 . GLN A 1 60  ? 98.583  103.329 147.130 1.00 76.86 ? 103 GLN A OE1 1 
ATOM 442  N NE2 . GLN A 1 60  ? 99.430  102.457 149.017 1.00 77.94 ? 103 GLN A NE2 1 
ATOM 443  N N   . SER A 1 61  ? 96.839  108.465 147.510 1.00 72.45 ? 104 SER A N   1 
ATOM 444  C CA  . SER A 1 61  ? 96.096  109.354 146.616 1.00 70.73 ? 104 SER A CA  1 
ATOM 445  C C   . SER A 1 61  ? 96.370  110.794 147.038 1.00 67.80 ? 104 SER A C   1 
ATOM 446  O O   . SER A 1 61  ? 95.729  111.305 147.961 1.00 72.99 ? 104 SER A O   1 
ATOM 447  C CB  . SER A 1 61  ? 94.608  109.037 146.647 1.00 68.30 ? 104 SER A CB  1 
ATOM 448  O OG  . SER A 1 61  ? 94.156  108.859 147.977 1.00 68.04 ? 104 SER A OG  1 
ATOM 449  N N   . THR A 1 62  ? 97.318  111.439 146.360 1.00 55.39 ? 105 THR A N   1 
ATOM 450  C CA  . THR A 1 62  ? 97.684  112.818 146.642 1.00 56.36 ? 105 THR A CA  1 
ATOM 451  C C   . THR A 1 62  ? 97.747  113.611 145.345 1.00 58.83 ? 105 THR A C   1 
ATOM 452  O O   . THR A 1 62  ? 97.900  113.054 144.256 1.00 63.74 ? 105 THR A O   1 
ATOM 453  C CB  . THR A 1 62  ? 99.039  112.930 147.359 1.00 64.66 ? 105 THR A CB  1 
ATOM 454  O OG1 . THR A 1 62  ? 100.090 113.008 146.388 1.00 66.07 ? 105 THR A OG1 1 
ATOM 455  C CG2 . THR A 1 62  ? 99.282  111.736 148.259 1.00 66.18 ? 105 THR A CG2 1 
ATOM 456  N N   . SER A 1 63  ? 97.626  114.927 145.481 1.00 59.73 ? 106 SER A N   1 
ATOM 457  C CA  . SER A 1 63  ? 97.798  115.858 144.378 1.00 60.74 ? 106 SER A CA  1 
ATOM 458  C C   . SER A 1 63  ? 99.086  116.643 144.583 1.00 59.33 ? 106 SER A C   1 
ATOM 459  O O   . SER A 1 63  ? 99.310  117.215 145.654 1.00 62.99 ? 106 SER A O   1 
ATOM 460  C CB  . SER A 1 63  ? 96.609  116.816 144.271 1.00 61.00 ? 106 SER A CB  1 
ATOM 461  O OG  . SER A 1 63  ? 96.470  117.589 145.449 1.00 60.84 ? 106 SER A OG  1 
ATOM 462  N N   . GLY A 1 64  ? 99.929  116.668 143.556 1.00 55.69 ? 107 GLY A N   1 
ATOM 463  C CA  . GLY A 1 64  ? 101.226 117.300 143.680 1.00 55.95 ? 107 GLY A CA  1 
ATOM 464  C C   . GLY A 1 64  ? 101.566 118.248 142.551 1.00 59.04 ? 107 GLY A C   1 
ATOM 465  O O   . GLY A 1 64  ? 100.688 118.922 142.006 1.00 65.56 ? 107 GLY A O   1 
ATOM 466  N N   . VAL A 1 65  ? 102.852 118.307 142.199 1.00 56.82 ? 108 VAL A N   1 
ATOM 467  C CA  . VAL A 1 65  ? 103.306 119.229 141.161 1.00 55.56 ? 108 VAL A CA  1 
ATOM 468  C C   . VAL A 1 65  ? 102.679 118.879 139.818 1.00 59.93 ? 108 VAL A C   1 
ATOM 469  O O   . VAL A 1 65  ? 102.202 119.759 139.091 1.00 63.20 ? 108 VAL A O   1 
ATOM 470  C CB  . VAL A 1 65  ? 104.845 119.225 141.088 1.00 58.69 ? 108 VAL A CB  1 
ATOM 471  C CG1 . VAL A 1 65  ? 105.321 119.855 139.792 1.00 62.56 ? 108 VAL A CG1 1 
ATOM 472  C CG2 . VAL A 1 65  ? 105.431 119.951 142.286 1.00 56.90 ? 108 VAL A CG2 1 
ATOM 473  N N   . MET A 1 66  ? 102.658 117.595 139.472 1.00 53.96 ? 109 MET A N   1 
ATOM 474  C CA  . MET A 1 66  ? 102.150 117.142 138.185 1.00 53.02 ? 109 MET A CA  1 
ATOM 475  C C   . MET A 1 66  ? 100.737 116.578 138.268 1.00 54.57 ? 109 MET A C   1 
ATOM 476  O O   . MET A 1 66  ? 100.278 115.946 137.312 1.00 58.90 ? 109 MET A O   1 
ATOM 477  C CB  . MET A 1 66  ? 103.096 116.103 137.585 1.00 52.49 ? 109 MET A CB  1 
ATOM 478  C CG  . MET A 1 66  ? 104.559 116.485 137.685 1.00 55.48 ? 109 MET A CG  1 
ATOM 479  S SD  . MET A 1 66  ? 105.653 115.348 136.818 1.00 66.12 ? 109 MET A SD  1 
ATOM 480  C CE  . MET A 1 66  ? 104.680 113.850 136.831 1.00 59.79 ? 109 MET A CE  1 
ATOM 481  N N   . GLY A 1 67  ? 100.040 116.788 139.380 1.00 54.78 ? 110 GLY A N   1 
ATOM 482  C CA  . GLY A 1 67  ? 98.658  116.368 139.482 1.00 55.26 ? 110 GLY A CA  1 
ATOM 483  C C   . GLY A 1 67  ? 98.435  115.196 140.412 1.00 61.15 ? 110 GLY A C   1 
ATOM 484  O O   . GLY A 1 67  ? 99.181  115.006 141.377 1.00 66.89 ? 110 GLY A O   1 
ATOM 485  N N   . SER A 1 68  ? 97.403  114.405 140.131 1.00 56.44 ? 111 SER A N   1 
ATOM 486  C CA  . SER A 1 68  ? 97.083  113.257 140.964 1.00 55.18 ? 111 SER A CA  1 
ATOM 487  C C   . SER A 1 68  ? 98.175  112.199 140.865 1.00 54.48 ? 111 SER A C   1 
ATOM 488  O O   . SER A 1 68  ? 98.835  112.048 139.835 1.00 60.78 ? 111 SER A O   1 
ATOM 489  C CB  . SER A 1 68  ? 95.738  112.661 140.553 1.00 57.19 ? 111 SER A CB  1 
ATOM 490  O OG  . SER A 1 68  ? 94.672  113.535 140.879 1.00 60.25 ? 111 SER A OG  1 
ATOM 491  N N   . GLY A 1 69  ? 98.362  111.463 141.956 1.00 56.28 ? 112 GLY A N   1 
ATOM 492  C CA  . GLY A 1 69  ? 99.388  110.432 141.979 1.00 59.38 ? 112 GLY A CA  1 
ATOM 493  C C   . GLY A 1 69  ? 99.612  109.900 143.378 1.00 63.40 ? 112 GLY A C   1 
ATOM 494  O O   . GLY A 1 69  ? 98.713  109.933 144.225 1.00 66.13 ? 112 GLY A O   1 
ATOM 495  N N   . GLN A 1 70  ? 100.827 109.406 143.606 1.00 62.83 ? 113 GLN A N   1 
ATOM 496  C CA  . GLN A 1 70  ? 101.212 108.822 144.881 1.00 60.03 ? 113 GLN A CA  1 
ATOM 497  C C   . GLN A 1 70  ? 102.508 109.460 145.363 1.00 61.55 ? 113 GLN A C   1 
ATOM 498  O O   . GLN A 1 70  ? 103.294 109.992 144.576 1.00 59.56 ? 113 GLN A O   1 
ATOM 499  C CB  . GLN A 1 70  ? 101.382 107.301 144.774 1.00 63.33 ? 113 GLN A CB  1 
ATOM 500  C CG  . GLN A 1 70  ? 100.130 106.568 144.329 1.00 62.00 ? 113 GLN A CG  1 
ATOM 501  C CD  . GLN A 1 70  ? 100.300 105.064 144.339 1.00 58.20 ? 113 GLN A CD  1 
ATOM 502  O OE1 . GLN A 1 70  ? 99.402  104.329 144.744 1.00 57.72 ? 113 GLN A OE1 1 
ATOM 503  N NE2 . GLN A 1 70  ? 101.457 104.598 143.889 1.00 60.30 ? 113 GLN A NE2 1 
ATOM 504  N N   . ARG A 1 71  ? 102.720 109.403 146.677 1.00 66.93 ? 114 ARG A N   1 
ATOM 505  C CA  . ARG A 1 71  ? 103.908 109.979 147.288 1.00 58.76 ? 114 ARG A CA  1 
ATOM 506  C C   . ARG A 1 71  ? 104.259 109.197 148.545 1.00 59.96 ? 114 ARG A C   1 
ATOM 507  O O   . ARG A 1 71  ? 103.372 108.809 149.309 1.00 61.46 ? 114 ARG A O   1 
ATOM 508  C CB  . ARG A 1 71  ? 103.698 111.459 147.630 1.00 63.16 ? 114 ARG A CB  1 
ATOM 509  C CG  . ARG A 1 71  ? 104.938 112.158 148.162 1.00 63.99 ? 114 ARG A CG  1 
ATOM 510  C CD  . ARG A 1 71  ? 104.648 113.596 148.565 1.00 60.41 ? 114 ARG A CD  1 
ATOM 511  N NE  . ARG A 1 71  ? 103.270 113.784 149.001 1.00 56.53 ? 114 ARG A NE  1 
ATOM 512  C CZ  . ARG A 1 71  ? 102.462 114.727 148.538 1.00 60.20 ? 114 ARG A CZ  1 
ATOM 513  N NH1 . ARG A 1 71  ? 102.858 115.584 147.613 1.00 61.99 ? 114 ARG A NH1 1 
ATOM 514  N NH2 . ARG A 1 71  ? 101.225 114.812 149.018 1.00 65.45 ? 114 ARG A NH2 1 
ATOM 515  N N   . MET A 1 72  ? 105.555 108.965 148.747 1.00 63.10 ? 115 MET A N   1 
ATOM 516  C CA  . MET A 1 72  ? 106.053 108.346 149.966 1.00 61.06 ? 115 MET A CA  1 
ATOM 517  C C   . MET A 1 72  ? 107.288 109.100 150.438 1.00 62.56 ? 115 MET A C   1 
ATOM 518  O O   . MET A 1 72  ? 108.064 109.617 149.630 1.00 60.67 ? 115 MET A O   1 
ATOM 519  C CB  . MET A 1 72  ? 106.381 106.860 149.767 1.00 61.54 ? 115 MET A CB  1 
ATOM 520  C CG  . MET A 1 72  ? 107.319 106.560 148.612 1.00 65.61 ? 115 MET A CG  1 
ATOM 521  S SD  . MET A 1 72  ? 108.424 105.188 148.997 1.00 66.74 ? 115 MET A SD  1 
ATOM 522  C CE  . MET A 1 72  ? 109.650 105.358 147.707 1.00 62.65 ? 115 MET A CE  1 
ATOM 523  N N   . THR A 1 73  ? 107.462 109.156 151.757 1.00 64.70 ? 116 THR A N   1 
ATOM 524  C CA  . THR A 1 73  ? 108.518 109.940 152.383 1.00 60.47 ? 116 THR A CA  1 
ATOM 525  C C   . THR A 1 73  ? 109.455 109.038 153.174 1.00 64.73 ? 116 THR A C   1 
ATOM 526  O O   . THR A 1 73  ? 109.008 108.139 153.892 1.00 67.50 ? 116 THR A O   1 
ATOM 527  C CB  . THR A 1 73  ? 107.939 111.010 153.311 1.00 60.09 ? 116 THR A CB  1 
ATOM 528  O OG1 . THR A 1 73  ? 107.442 110.390 154.503 1.00 62.91 ? 116 THR A OG1 1 
ATOM 529  C CG2 . THR A 1 73  ? 106.806 111.758 152.625 1.00 63.33 ? 116 THR A CG2 1 
ATOM 530  N N   . ILE A 1 74  ? 110.757 109.290 153.042 1.00 59.28 ? 117 ILE A N   1 
ATOM 531  C CA  . ILE A 1 74  ? 111.792 108.562 153.767 1.00 47.82 ? 117 ILE A CA  1 
ATOM 532  C C   . ILE A 1 74  ? 112.539 109.548 154.654 1.00 50.07 ? 117 ILE A C   1 
ATOM 533  O O   . ILE A 1 74  ? 113.062 110.555 154.164 1.00 47.58 ? 117 ILE A O   1 
ATOM 534  C CB  . ILE A 1 74  ? 112.767 107.851 152.812 1.00 52.03 ? 117 ILE A CB  1 
ATOM 535  C CG1 . ILE A 1 74  ? 112.041 107.368 151.558 1.00 54.66 ? 117 ILE A CG1 1 
ATOM 536  C CG2 . ILE A 1 74  ? 113.449 106.688 153.517 1.00 58.58 ? 117 ILE A CG2 1 
ATOM 537  C CD1 . ILE A 1 74  ? 112.967 107.076 150.400 1.00 55.25 ? 117 ILE A CD1 1 
ATOM 538  N N   . THR A 1 75  ? 112.597 109.253 155.950 1.00 57.83 ? 118 THR A N   1 
ATOM 539  C CA  . THR A 1 75  ? 113.290 110.085 156.924 1.00 52.84 ? 118 THR A CA  1 
ATOM 540  C C   . THR A 1 75  ? 114.483 109.323 157.485 1.00 51.82 ? 118 THR A C   1 
ATOM 541  O O   . THR A 1 75  ? 114.337 108.188 157.949 1.00 59.55 ? 118 THR A O   1 
ATOM 542  C CB  . THR A 1 75  ? 112.353 110.500 158.061 1.00 52.62 ? 118 THR A CB  1 
ATOM 543  O OG1 . THR A 1 75  ? 112.042 109.357 158.866 1.00 53.97 ? 118 THR A OG1 1 
ATOM 544  C CG2 . THR A 1 75  ? 111.065 111.082 157.504 1.00 55.67 ? 118 THR A CG2 1 
ATOM 545  N N   . SER A 1 76  ? 115.657 109.949 157.444 1.00 50.33 ? 119 SER A N   1 
ATOM 546  C CA  . SER A 1 76  ? 116.883 109.345 157.943 1.00 48.04 ? 119 SER A CA  1 
ATOM 547  C C   . SER A 1 76  ? 117.655 110.355 158.780 1.00 57.07 ? 119 SER A C   1 
ATOM 548  O O   . SER A 1 76  ? 117.532 111.568 158.590 1.00 61.84 ? 119 SER A O   1 
ATOM 549  C CB  . SER A 1 76  ? 117.763 108.836 156.799 1.00 48.79 ? 119 SER A CB  1 
ATOM 550  O OG  . SER A 1 76  ? 118.218 109.908 155.993 1.00 51.74 ? 119 SER A OG  1 
ATOM 551  N N   . GLN A 1 77  ? 118.458 109.840 159.711 1.00 59.08 ? 120 GLN A N   1 
ATOM 552  C CA  . GLN A 1 77  ? 119.229 110.663 160.631 1.00 51.51 ? 120 GLN A CA  1 
ATOM 553  C C   . GLN A 1 77  ? 120.688 110.233 160.619 1.00 58.72 ? 120 GLN A C   1 
ATOM 554  O O   . GLN A 1 77  ? 120.992 109.038 160.583 1.00 61.65 ? 120 GLN A O   1 
ATOM 555  C CB  . GLN A 1 77  ? 118.677 110.567 162.057 1.00 50.27 ? 120 GLN A CB  1 
ATOM 556  C CG  . GLN A 1 77  ? 119.492 111.312 163.097 1.00 52.33 ? 120 GLN A CG  1 
ATOM 557  C CD  . GLN A 1 77  ? 118.993 111.070 164.505 1.00 57.85 ? 120 GLN A CD  1 
ATOM 558  O OE1 . GLN A 1 77  ? 119.736 110.602 165.367 1.00 62.08 ? 120 GLN A OE1 1 
ATOM 559  N NE2 . GLN A 1 77  ? 117.727 111.386 164.746 1.00 55.23 ? 120 GLN A NE2 1 
ATOM 560  N N   . SER A 1 78  ? 121.586 111.214 160.650 1.00 65.71 ? 121 SER A N   1 
ATOM 561  C CA  . SER A 1 78  ? 123.019 110.977 160.752 1.00 67.07 ? 121 SER A CA  1 
ATOM 562  C C   . SER A 1 78  ? 123.494 111.402 162.134 1.00 69.64 ? 121 SER A C   1 
ATOM 563  O O   . SER A 1 78  ? 123.186 112.509 162.586 1.00 68.19 ? 121 SER A O   1 
ATOM 564  C CB  . SER A 1 78  ? 123.781 111.743 159.670 1.00 69.83 ? 121 SER A CB  1 
ATOM 565  O OG  . SER A 1 78  ? 125.105 112.029 160.084 1.00 72.97 ? 121 SER A OG  1 
ATOM 566  N N   . MET A 1 79  ? 124.239 110.523 162.802 1.00 77.58 ? 122 MET A N   1 
ATOM 567  C CA  . MET A 1 79  ? 124.716 110.808 164.150 1.00 75.18 ? 122 MET A CA  1 
ATOM 568  C C   . MET A 1 79  ? 126.008 111.614 164.155 1.00 75.90 ? 122 MET A C   1 
ATOM 569  O O   . MET A 1 79  ? 126.205 112.458 165.035 1.00 78.71 ? 122 MET A O   1 
ATOM 570  C CB  . MET A 1 79  ? 124.917 109.504 164.924 1.00 77.77 ? 122 MET A CB  1 
ATOM 571  C CG  . MET A 1 79  ? 123.901 109.279 166.031 1.00 79.17 ? 122 MET A CG  1 
ATOM 572  S SD  . MET A 1 79  ? 124.487 108.129 167.289 1.00 96.26 ? 122 MET A SD  1 
ATOM 573  C CE  . MET A 1 79  ? 124.639 106.625 166.329 1.00 81.45 ? 122 MET A CE  1 
ATOM 574  N N   . SER A 1 80  ? 126.899 111.364 163.194 1.00 69.61 ? 123 SER A N   1 
ATOM 575  C CA  . SER A 1 80  ? 128.173 112.077 163.162 1.00 68.02 ? 123 SER A CA  1 
ATOM 576  C C   . SER A 1 80  ? 127.975 113.564 162.898 1.00 66.74 ? 123 SER A C   1 
ATOM 577  O O   . SER A 1 80  ? 128.636 114.403 163.521 1.00 68.64 ? 123 SER A O   1 
ATOM 578  C CB  . SER A 1 80  ? 129.090 111.463 162.106 1.00 71.68 ? 123 SER A CB  1 
ATOM 579  O OG  . SER A 1 80  ? 129.085 112.233 160.917 1.00 74.58 ? 123 SER A OG  1 
ATOM 580  N N   . THR A 1 81  ? 127.071 113.911 161.982 1.00 66.22 ? 124 THR A N   1 
ATOM 581  C CA  . THR A 1 81  ? 126.846 115.303 161.616 1.00 65.46 ? 124 THR A CA  1 
ATOM 582  C C   . THR A 1 81  ? 125.610 115.911 162.263 1.00 68.38 ? 124 THR A C   1 
ATOM 583  O O   . THR A 1 81  ? 125.513 117.141 162.333 1.00 70.11 ? 124 THR A O   1 
ATOM 584  C CB  . THR A 1 81  ? 126.724 115.439 160.094 1.00 65.65 ? 124 THR A CB  1 
ATOM 585  O OG1 . THR A 1 81  ? 125.682 114.579 159.617 1.00 70.44 ? 124 THR A OG1 1 
ATOM 586  C CG2 . THR A 1 81  ? 128.032 115.061 159.420 1.00 66.92 ? 124 THR A CG2 1 
ATOM 587  N N   . GLY A 1 82  ? 124.672 115.093 162.733 1.00 62.91 ? 125 GLY A N   1 
ATOM 588  C CA  . GLY A 1 82  ? 123.452 115.598 163.322 1.00 58.24 ? 125 GLY A CA  1 
ATOM 589  C C   . GLY A 1 82  ? 122.370 115.972 162.335 1.00 61.34 ? 125 GLY A C   1 
ATOM 590  O O   . GLY A 1 82  ? 121.294 116.411 162.761 1.00 65.08 ? 125 GLY A O   1 
ATOM 591  N N   . LEU A 1 83  ? 122.615 115.816 161.038 1.00 57.70 ? 126 LEU A N   1 
ATOM 592  C CA  . LEU A 1 83  ? 121.640 116.203 160.031 1.00 54.11 ? 126 LEU A CA  1 
ATOM 593  C C   . LEU A 1 83  ? 120.475 115.222 159.991 1.00 57.18 ? 126 LEU A C   1 
ATOM 594  O O   . LEU A 1 83  ? 120.602 114.052 160.360 1.00 64.01 ? 126 LEU A O   1 
ATOM 595  C CB  . LEU A 1 83  ? 122.298 116.280 158.654 1.00 55.04 ? 126 LEU A CB  1 
ATOM 596  C CG  . LEU A 1 83  ? 123.062 117.560 158.317 1.00 57.27 ? 126 LEU A CG  1 
ATOM 597  C CD1 . LEU A 1 83  ? 123.928 117.354 157.088 1.00 59.06 ? 126 LEU A CD1 1 
ATOM 598  C CD2 . LEU A 1 83  ? 122.100 118.716 158.109 1.00 57.74 ? 126 LEU A CD2 1 
ATOM 599  N N   . ILE A 1 84  ? 119.326 115.717 159.539 1.00 55.23 ? 127 ILE A N   1 
ATOM 600  C CA  . ILE A 1 84  ? 118.134 114.907 159.321 1.00 53.69 ? 127 ILE A CA  1 
ATOM 601  C C   . ILE A 1 84  ? 117.709 115.083 157.871 1.00 58.55 ? 127 ILE A C   1 
ATOM 602  O O   . ILE A 1 84  ? 117.545 116.215 157.402 1.00 62.81 ? 127 ILE A O   1 
ATOM 603  C CB  . ILE A 1 84  ? 116.996 115.299 160.280 1.00 47.05 ? 127 ILE A CB  1 
ATOM 604  C CG1 . ILE A 1 84  ? 117.366 114.941 161.719 1.00 51.70 ? 127 ILE A CG1 1 
ATOM 605  C CG2 . ILE A 1 84  ? 115.702 114.614 159.883 1.00 48.83 ? 127 ILE A CG2 1 
ATOM 606  C CD1 . ILE A 1 84  ? 116.413 115.501 162.748 1.00 56.69 ? 127 ILE A CD1 1 
ATOM 607  N N   . ARG A 1 85  ? 117.532 113.971 157.164 1.00 56.47 ? 128 ARG A N   1 
ATOM 608  C CA  . ARG A 1 85  ? 117.189 113.987 155.750 1.00 48.04 ? 128 ARG A CA  1 
ATOM 609  C C   . ARG A 1 85  ? 115.752 113.533 155.546 1.00 51.93 ? 128 ARG A C   1 
ATOM 610  O O   . ARG A 1 85  ? 115.284 112.601 156.207 1.00 60.06 ? 128 ARG A O   1 
ATOM 611  C CB  . ARG A 1 85  ? 118.128 113.090 154.940 1.00 52.39 ? 128 ARG A CB  1 
ATOM 612  C CG  . ARG A 1 85  ? 118.109 113.382 153.450 1.00 56.98 ? 128 ARG A CG  1 
ATOM 613  C CD  . ARG A 1 85  ? 117.928 112.119 152.629 1.00 54.67 ? 128 ARG A CD  1 
ATOM 614  N NE  . ARG A 1 85  ? 119.161 111.348 152.532 1.00 53.39 ? 128 ARG A NE  1 
ATOM 615  C CZ  . ARG A 1 85  ? 119.315 110.122 153.010 1.00 57.65 ? 128 ARG A CZ  1 
ATOM 616  N NH1 . ARG A 1 85  ? 118.328 109.492 153.624 1.00 54.20 ? 128 ARG A NH1 1 
ATOM 617  N NH2 . ARG A 1 85  ? 120.488 109.513 152.868 1.00 61.28 ? 128 ARG A NH2 1 
ATOM 618  N N   . THR A 1 86  ? 115.058 114.199 154.627 1.00 53.75 ? 129 THR A N   1 
ATOM 619  C CA  . THR A 1 86  ? 113.706 113.825 154.231 1.00 53.24 ? 129 THR A CA  1 
ATOM 620  C C   . THR A 1 86  ? 113.678 113.673 152.718 1.00 56.05 ? 129 THR A C   1 
ATOM 621  O O   . THR A 1 86  ? 114.052 114.599 151.992 1.00 59.94 ? 129 THR A O   1 
ATOM 622  C CB  . THR A 1 86  ? 112.681 114.863 154.692 1.00 53.22 ? 129 THR A CB  1 
ATOM 623  O OG1 . THR A 1 86  ? 112.672 114.922 156.123 1.00 54.38 ? 129 THR A OG1 1 
ATOM 624  C CG2 . THR A 1 86  ? 111.292 114.495 154.200 1.00 56.06 ? 129 THR A CG2 1 
ATOM 625  N N   . TYR A 1 87  ? 113.236 112.510 152.249 1.00 52.96 ? 130 TYR A N   1 
ATOM 626  C CA  . TYR A 1 87  ? 113.213 112.172 150.833 1.00 46.65 ? 130 TYR A CA  1 
ATOM 627  C C   . TYR A 1 87  ? 111.768 111.987 150.395 1.00 59.17 ? 130 TYR A C   1 
ATOM 628  O O   . TYR A 1 87  ? 111.018 111.241 151.030 1.00 61.52 ? 130 TYR A O   1 
ATOM 629  C CB  . TYR A 1 87  ? 114.015 110.896 150.572 1.00 53.42 ? 130 TYR A CB  1 
ATOM 630  C CG  . TYR A 1 87  ? 114.571 110.773 149.174 1.00 55.90 ? 130 TYR A CG  1 
ATOM 631  C CD1 . TYR A 1 87  ? 115.619 111.574 148.751 1.00 52.32 ? 130 TYR A CD1 1 
ATOM 632  C CD2 . TYR A 1 87  ? 114.055 109.845 148.282 1.00 60.52 ? 130 TYR A CD2 1 
ATOM 633  C CE1 . TYR A 1 87  ? 116.133 111.460 147.477 1.00 55.59 ? 130 TYR A CE1 1 
ATOM 634  C CE2 . TYR A 1 87  ? 114.562 109.725 147.005 1.00 60.73 ? 130 TYR A CE2 1 
ATOM 635  C CZ  . TYR A 1 87  ? 115.601 110.535 146.608 1.00 59.34 ? 130 TYR A CZ  1 
ATOM 636  O OH  . TYR A 1 87  ? 116.110 110.419 145.336 1.00 59.62 ? 130 TYR A OH  1 
ATOM 637  N N   . VAL A 1 88  ? 111.382 112.659 149.314 1.00 62.40 ? 131 VAL A N   1 
ATOM 638  C CA  . VAL A 1 88  ? 110.012 112.624 148.815 1.00 56.66 ? 131 VAL A CA  1 
ATOM 639  C C   . VAL A 1 88  ? 110.036 112.215 147.349 1.00 59.29 ? 131 VAL A C   1 
ATOM 640  O O   . VAL A 1 88  ? 110.758 112.814 146.545 1.00 59.73 ? 131 VAL A O   1 
ATOM 641  C CB  . VAL A 1 88  ? 109.307 113.982 148.993 1.00 55.05 ? 131 VAL A CB  1 
ATOM 642  C CG1 . VAL A 1 88  ? 108.197 114.153 147.969 1.00 56.79 ? 131 VAL A CG1 1 
ATOM 643  C CG2 . VAL A 1 88  ? 108.757 114.107 150.402 1.00 56.83 ? 131 VAL A CG2 1 
ATOM 644  N N   . LEU A 1 89  ? 109.251 111.195 147.008 1.00 53.37 ? 132 LEU A N   1 
ATOM 645  C CA  . LEU A 1 89  ? 109.122 110.710 145.642 1.00 50.91 ? 132 LEU A CA  1 
ATOM 646  C C   . LEU A 1 89  ? 107.671 110.835 145.198 1.00 59.36 ? 132 LEU A C   1 
ATOM 647  O O   . LEU A 1 89  ? 106.754 110.487 145.946 1.00 56.41 ? 132 LEU A O   1 
ATOM 648  C CB  . LEU A 1 89  ? 109.586 109.255 145.526 1.00 52.05 ? 132 LEU A CB  1 
ATOM 649  C CG  . LEU A 1 89  ? 111.093 109.016 145.643 1.00 53.09 ? 132 LEU A CG  1 
ATOM 650  C CD1 . LEU A 1 89  ? 111.426 107.550 145.442 1.00 57.68 ? 132 LEU A CD1 1 
ATOM 651  C CD2 . LEU A 1 89  ? 111.843 109.872 144.646 1.00 53.47 ? 132 LEU A CD2 1 
ATOM 652  N N   . GLU A 1 90  ? 107.466 111.333 143.979 1.00 64.75 ? 133 GLU A N   1 
ATOM 653  C CA  . GLU A 1 90  ? 106.130 111.587 143.458 1.00 59.39 ? 133 GLU A CA  1 
ATOM 654  C C   . GLU A 1 90  ? 105.999 111.063 142.036 1.00 58.99 ? 133 GLU A C   1 
ATOM 655  O O   . GLU A 1 90  ? 106.913 111.213 141.220 1.00 60.11 ? 133 GLU A O   1 
ATOM 656  C CB  . GLU A 1 90  ? 105.799 113.084 143.484 1.00 59.81 ? 133 GLU A CB  1 
ATOM 657  C CG  . GLU A 1 90  ? 105.197 113.566 144.791 1.00 63.23 ? 133 GLU A CG  1 
ATOM 658  C CD  . GLU A 1 90  ? 104.886 115.048 144.774 1.00 67.22 ? 133 GLU A CD  1 
ATOM 659  O OE1 . GLU A 1 90  ? 105.100 115.689 143.724 1.00 67.84 ? 133 GLU A OE1 1 
ATOM 660  O OE2 . GLU A 1 90  ? 104.427 115.573 145.810 1.00 66.87 ? 133 GLU A OE2 1 
ATOM 661  N N   . THR A 1 91  ? 104.851 110.453 141.748 1.00 54.91 ? 134 THR A N   1 
ATOM 662  C CA  . THR A 1 91  ? 104.496 109.994 140.414 1.00 54.51 ? 134 THR A CA  1 
ATOM 663  C C   . THR A 1 91  ? 103.103 110.506 140.074 1.00 62.82 ? 134 THR A C   1 
ATOM 664  O O   . THR A 1 91  ? 102.351 110.939 140.951 1.00 66.34 ? 134 THR A O   1 
ATOM 665  C CB  . THR A 1 91  ? 104.527 108.463 140.304 1.00 59.11 ? 134 THR A CB  1 
ATOM 666  O OG1 . THR A 1 91  ? 103.515 107.903 141.148 1.00 60.72 ? 134 THR A OG1 1 
ATOM 667  C CG2 . THR A 1 91  ? 105.884 107.920 140.718 1.00 60.62 ? 134 THR A CG2 1 
ATOM 668  N N   . SER A 1 92  ? 102.760 110.458 138.788 1.00 59.31 ? 135 SER A N   1 
ATOM 669  C CA  . SER A 1 92  ? 101.464 110.927 138.318 1.00 53.42 ? 135 SER A CA  1 
ATOM 670  C C   . SER A 1 92  ? 100.828 109.893 137.402 1.00 50.24 ? 135 SER A C   1 
ATOM 671  O O   . SER A 1 92  ? 101.518 109.152 136.699 1.00 53.92 ? 135 SER A O   1 
ATOM 672  C CB  . SER A 1 92  ? 101.580 112.261 137.579 1.00 56.14 ? 135 SER A CB  1 
ATOM 673  O OG  . SER A 1 92  ? 102.014 112.060 136.248 1.00 57.81 ? 135 SER A OG  1 
ATOM 674  N N   . ASP A 1 93  ? 99.493  109.858 137.417 1.00 49.99 ? 136 ASP A N   1 
ATOM 675  C CA  . ASP A 1 93  ? 98.766  108.901 136.589 1.00 55.27 ? 136 ASP A CA  1 
ATOM 676  C C   . ASP A 1 93  ? 98.776  109.308 135.120 1.00 58.14 ? 136 ASP A C   1 
ATOM 677  O O   . ASP A 1 93  ? 98.931  108.458 134.237 1.00 60.43 ? 136 ASP A O   1 
ATOM 678  C CB  . ASP A 1 93  ? 97.330  108.758 137.089 1.00 53.82 ? 136 ASP A CB  1 
ATOM 679  C CG  . ASP A 1 93  ? 97.246  108.644 138.596 1.00 61.75 ? 136 ASP A CG  1 
ATOM 680  O OD1 . ASP A 1 93  ? 97.321  109.687 139.276 1.00 62.96 ? 136 ASP A OD1 1 
ATOM 681  O OD2 . ASP A 1 93  ? 97.104  107.510 139.100 1.00 64.49 ? 136 ASP A OD2 1 
ATOM 682  N N   . ILE A 1 94  ? 98.603  110.601 134.840 1.00 52.40 ? 137 ILE A N   1 
ATOM 683  C CA  . ILE A 1 94  ? 98.492  111.055 133.457 1.00 46.64 ? 137 ILE A CA  1 
ATOM 684  C C   . ILE A 1 94  ? 99.818  110.882 132.727 1.00 48.40 ? 137 ILE A C   1 
ATOM 685  O O   . ILE A 1 94  ? 99.868  110.342 131.616 1.00 56.18 ? 137 ILE A O   1 
ATOM 686  C CB  . ILE A 1 94  ? 98.003  112.514 133.412 1.00 52.87 ? 137 ILE A CB  1 
ATOM 687  C CG1 . ILE A 1 94  ? 96.476  112.562 133.464 1.00 54.42 ? 137 ILE A CG1 1 
ATOM 688  C CG2 . ILE A 1 94  ? 98.503  113.216 132.159 1.00 54.76 ? 137 ILE A CG2 1 
ATOM 689  C CD1 . ILE A 1 94  ? 95.803  111.815 132.335 1.00 54.80 ? 137 ILE A CD1 1 
ATOM 690  N N   . GLU A 1 95  ? 100.912 111.327 133.339 1.00 47.99 ? 138 GLU A N   1 
ATOM 691  C CA  . GLU A 1 95  ? 102.220 111.217 132.713 1.00 47.33 ? 138 GLU A CA  1 
ATOM 692  C C   . GLU A 1 95  ? 102.755 109.798 132.846 1.00 55.62 ? 138 GLU A C   1 
ATOM 693  O O   . GLU A 1 95  ? 102.587 109.149 133.882 1.00 57.23 ? 138 GLU A O   1 
ATOM 694  C CB  . GLU A 1 95  ? 103.200 112.208 133.337 1.00 51.14 ? 138 GLU A CB  1 
ATOM 695  C CG  . GLU A 1 95  ? 103.081 113.613 132.786 1.00 57.48 ? 138 GLU A CG  1 
ATOM 696  C CD  . GLU A 1 95  ? 103.468 113.694 131.324 1.00 63.38 ? 138 GLU A CD  1 
ATOM 697  O OE1 . GLU A 1 95  ? 104.416 112.988 130.921 1.00 63.85 ? 138 GLU A OE1 1 
ATOM 698  O OE2 . GLU A 1 95  ? 102.823 114.460 130.579 1.00 60.75 ? 138 GLU A OE2 1 
ATOM 699  N N   . GLU A 1 96  ? 103.402 109.320 131.788 1.00 61.18 ? 139 GLU A N   1 
ATOM 700  C CA  . GLU A 1 96  ? 103.907 107.956 131.727 1.00 58.89 ? 139 GLU A CA  1 
ATOM 701  C C   . GLU A 1 96  ? 105.397 107.949 132.040 1.00 58.99 ? 139 GLU A C   1 
ATOM 702  O O   . GLU A 1 96  ? 106.190 108.572 131.326 1.00 61.43 ? 139 GLU A O   1 
ATOM 703  C CB  . GLU A 1 96  ? 103.646 107.343 130.351 1.00 62.39 ? 139 GLU A CB  1 
ATOM 704  C CG  . GLU A 1 96  ? 104.305 105.991 130.136 1.00 63.12 ? 139 GLU A CG  1 
ATOM 705  C CD  . GLU A 1 96  ? 104.062 105.440 128.745 1.00 67.07 ? 139 GLU A CD  1 
ATOM 706  O OE1 . GLU A 1 96  ? 103.396 106.125 127.941 1.00 63.49 ? 139 GLU A OE1 1 
ATOM 707  O OE2 . GLU A 1 96  ? 104.538 104.322 128.456 1.00 63.74 ? 139 GLU A OE2 1 
ATOM 708  N N   . GLY A 1 97  ? 105.771 107.238 133.101 1.00 51.44 ? 140 GLY A N   1 
ATOM 709  C CA  . GLY A 1 97  ? 107.166 107.036 133.439 1.00 45.83 ? 140 GLY A CA  1 
ATOM 710  C C   . GLY A 1 97  ? 107.951 108.258 133.868 1.00 49.74 ? 140 GLY A C   1 
ATOM 711  O O   . GLY A 1 97  ? 109.075 108.459 133.404 1.00 56.33 ? 140 GLY A O   1 
ATOM 712  N N   . VAL A 1 98  ? 107.385 109.085 134.744 1.00 48.18 ? 141 VAL A N   1 
ATOM 713  C CA  . VAL A 1 98  ? 108.072 110.258 135.273 1.00 40.28 ? 141 VAL A CA  1 
ATOM 714  C C   . VAL A 1 98  ? 107.981 110.227 136.792 1.00 43.04 ? 141 VAL A C   1 
ATOM 715  O O   . VAL A 1 98  ? 106.900 110.002 137.348 1.00 50.27 ? 141 VAL A O   1 
ATOM 716  C CB  . VAL A 1 98  ? 107.484 111.568 134.716 1.00 44.58 ? 141 VAL A CB  1 
ATOM 717  C CG1 . VAL A 1 98  ? 107.924 112.751 135.559 1.00 49.25 ? 141 VAL A CG1 1 
ATOM 718  C CG2 . VAL A 1 98  ? 107.905 111.762 133.271 1.00 46.55 ? 141 VAL A CG2 1 
ATOM 719  N N   . VAL A 1 99  ? 109.112 110.450 137.460 1.00 44.43 ? 142 VAL A N   1 
ATOM 720  C CA  . VAL A 1 99  ? 109.202 110.426 138.916 1.00 41.08 ? 142 VAL A CA  1 
ATOM 721  C C   . VAL A 1 99  ? 109.770 111.758 139.388 1.00 50.29 ? 142 VAL A C   1 
ATOM 722  O O   . VAL A 1 99  ? 110.770 112.239 138.844 1.00 51.85 ? 142 VAL A O   1 
ATOM 723  C CB  . VAL A 1 99  ? 110.067 109.251 139.410 1.00 38.45 ? 142 VAL A CB  1 
ATOM 724  C CG1 . VAL A 1 99  ? 110.512 109.472 140.845 1.00 42.98 ? 142 VAL A CG1 1 
ATOM 725  C CG2 . VAL A 1 99  ? 109.304 107.946 139.287 1.00 44.58 ? 142 VAL A CG2 1 
ATOM 726  N N   . TYR A 1 100 ? 109.132 112.348 140.397 1.00 57.26 ? 143 TYR A N   1 
ATOM 727  C CA  . TYR A 1 100 ? 109.513 113.645 140.943 1.00 53.66 ? 143 TYR A CA  1 
ATOM 728  C C   . TYR A 1 100 ? 110.190 113.450 142.293 1.00 56.65 ? 143 TYR A C   1 
ATOM 729  O O   . TYR A 1 100 ? 109.668 112.734 143.154 1.00 54.14 ? 143 TYR A O   1 
ATOM 730  C CB  . TYR A 1 100 ? 108.286 114.548 141.084 1.00 56.16 ? 143 TYR A CB  1 
ATOM 731  C CG  . TYR A 1 100 ? 108.582 115.964 141.523 1.00 55.44 ? 143 TYR A CG  1 
ATOM 732  C CD1 . TYR A 1 100 ? 109.384 116.797 140.758 1.00 53.38 ? 143 TYR A CD1 1 
ATOM 733  C CD2 . TYR A 1 100 ? 108.042 116.472 142.696 1.00 53.64 ? 143 TYR A CD2 1 
ATOM 734  C CE1 . TYR A 1 100 ? 109.649 118.093 141.153 1.00 45.98 ? 143 TYR A CE1 1 
ATOM 735  C CE2 . TYR A 1 100 ? 108.302 117.765 143.098 1.00 53.14 ? 143 TYR A CE2 1 
ATOM 736  C CZ  . TYR A 1 100 ? 109.105 118.570 142.324 1.00 48.95 ? 143 TYR A CZ  1 
ATOM 737  O OH  . TYR A 1 100 ? 109.364 119.859 142.724 1.00 55.39 ? 143 TYR A OH  1 
ATOM 738  N N   . THR A 1 101 ? 111.344 114.090 142.477 1.00 61.31 ? 144 THR A N   1 
ATOM 739  C CA  . THR A 1 101 ? 112.180 113.902 143.657 1.00 55.73 ? 144 THR A CA  1 
ATOM 740  C C   . THR A 1 101 ? 112.399 115.238 144.353 1.00 59.54 ? 144 THR A C   1 
ATOM 741  O O   . THR A 1 101 ? 112.719 116.236 143.700 1.00 63.77 ? 144 THR A O   1 
ATOM 742  C CB  . THR A 1 101 ? 113.530 113.285 143.274 1.00 63.55 ? 144 THR A CB  1 
ATOM 743  O OG1 . THR A 1 101 ? 113.328 111.960 142.771 1.00 63.92 ? 144 THR A OG1 1 
ATOM 744  C CG2 . THR A 1 101 ? 114.457 113.224 144.480 1.00 62.59 ? 144 THR A CG2 1 
ATOM 745  N N   . ALA A 1 102 ? 112.230 115.255 145.676 1.00 59.16 ? 145 ALA A N   1 
ATOM 746  C CA  . ALA A 1 102 ? 112.482 116.440 146.484 1.00 57.39 ? 145 ALA A CA  1 
ATOM 747  C C   . ALA A 1 102 ? 113.264 116.047 147.729 1.00 58.45 ? 145 ALA A C   1 
ATOM 748  O O   . ALA A 1 102 ? 113.034 114.979 148.301 1.00 59.81 ? 145 ALA A O   1 
ATOM 749  C CB  . ALA A 1 102 ? 111.175 117.136 146.883 1.00 56.28 ? 145 ALA A CB  1 
ATOM 750  N N   . THR A 1 103 ? 114.185 116.915 148.146 1.00 60.80 ? 146 THR A N   1 
ATOM 751  C CA  . THR A 1 103 ? 115.048 116.658 149.291 1.00 63.66 ? 146 THR A CA  1 
ATOM 752  C C   . THR A 1 103 ? 115.056 117.861 150.224 1.00 60.72 ? 146 THR A C   1 
ATOM 753  O O   . THR A 1 103 ? 115.057 119.009 149.770 1.00 61.79 ? 146 THR A O   1 
ATOM 754  C CB  . THR A 1 103 ? 116.484 116.347 148.850 1.00 63.41 ? 146 THR A CB  1 
ATOM 755  O OG1 . THR A 1 103 ? 116.910 117.318 147.887 1.00 62.19 ? 146 THR A OG1 1 
ATOM 756  C CG2 . THR A 1 103 ? 116.564 114.963 148.232 1.00 62.10 ? 146 THR A CG2 1 
ATOM 757  N N   . SER A 1 104 ? 115.066 117.591 151.529 1.00 51.22 ? 147 SER A N   1 
ATOM 758  C CA  . SER A 1 104 ? 115.162 118.631 152.543 1.00 51.95 ? 147 SER A CA  1 
ATOM 759  C C   . SER A 1 104 ? 116.085 118.165 153.660 1.00 51.49 ? 147 SER A C   1 
ATOM 760  O O   . SER A 1 104 ? 116.045 116.999 154.061 1.00 55.48 ? 147 SER A O   1 
ATOM 761  C CB  . SER A 1 104 ? 113.786 118.994 153.115 1.00 54.41 ? 147 SER A CB  1 
ATOM 762  O OG  . SER A 1 104 ? 113.235 117.914 153.845 1.00 59.86 ? 147 SER A OG  1 
ATOM 763  N N   . TYR A 1 105 ? 116.910 119.083 154.158 1.00 52.08 ? 148 TYR A N   1 
ATOM 764  C CA  . TYR A 1 105 ? 117.892 118.796 155.194 1.00 42.07 ? 148 TYR A CA  1 
ATOM 765  C C   . TYR A 1 105 ? 117.693 119.736 156.374 1.00 48.19 ? 148 TYR A C   1 
ATOM 766  O O   . TYR A 1 105 ? 117.427 120.928 156.192 1.00 57.45 ? 148 TYR A O   1 
ATOM 767  C CB  . TYR A 1 105 ? 119.316 118.939 154.657 1.00 45.78 ? 148 TYR A CB  1 
ATOM 768  C CG  . TYR A 1 105 ? 119.819 117.727 153.911 1.00 48.48 ? 148 TYR A CG  1 
ATOM 769  C CD1 . TYR A 1 105 ? 120.301 116.620 154.592 1.00 51.43 ? 148 TYR A CD1 1 
ATOM 770  C CD2 . TYR A 1 105 ? 119.811 117.690 152.525 1.00 53.60 ? 148 TYR A CD2 1 
ATOM 771  C CE1 . TYR A 1 105 ? 120.765 115.514 153.914 1.00 49.73 ? 148 TYR A CE1 1 
ATOM 772  C CE2 . TYR A 1 105 ? 120.270 116.586 151.839 1.00 49.03 ? 148 TYR A CE2 1 
ATOM 773  C CZ  . TYR A 1 105 ? 120.745 115.501 152.538 1.00 45.08 ? 148 TYR A CZ  1 
ATOM 774  O OH  . TYR A 1 105 ? 121.202 114.399 151.857 1.00 52.11 ? 148 TYR A OH  1 
ATOM 775  N N   . GLU A 1 106 ? 117.828 119.196 157.583 1.00 56.49 ? 149 GLU A N   1 
ATOM 776  C CA  . GLU A 1 106 ? 117.681 119.970 158.808 1.00 57.59 ? 149 GLU A CA  1 
ATOM 777  C C   . GLU A 1 106 ? 118.842 119.668 159.741 1.00 62.15 ? 149 GLU A C   1 
ATOM 778  O O   . GLU A 1 106 ? 119.184 118.501 159.954 1.00 65.85 ? 149 GLU A O   1 
ATOM 779  C CB  . GLU A 1 106 ? 116.352 119.661 159.504 1.00 56.81 ? 149 GLU A CB  1 
ATOM 780  C CG  . GLU A 1 106 ? 116.340 119.994 160.983 1.00 56.50 ? 149 GLU A CG  1 
ATOM 781  C CD  . GLU A 1 106 ? 114.941 120.046 161.556 1.00 64.77 ? 149 GLU A CD  1 
ATOM 782  O OE1 . GLU A 1 106 ? 113.976 119.850 160.788 1.00 64.89 ? 149 GLU A OE1 1 
ATOM 783  O OE2 . GLU A 1 106 ? 114.805 120.286 162.774 1.00 64.62 ? 149 GLU A OE2 1 
ATOM 784  N N   . ALA A 1 107 ? 119.443 120.718 160.295 1.00 65.96 ? 150 ALA A N   1 
ATOM 785  C CA  . ALA A 1 107 ? 120.520 120.592 161.267 1.00 64.15 ? 150 ALA A CA  1 
ATOM 786  C C   . ALA A 1 107 ? 119.958 120.870 162.655 1.00 64.58 ? 150 ALA A C   1 
ATOM 787  O O   . ALA A 1 107 ? 119.357 121.925 162.885 1.00 66.73 ? 150 ALA A O   1 
ATOM 788  C CB  . ALA A 1 107 ? 121.665 121.550 160.944 1.00 61.64 ? 150 ALA A CB  1 
ATOM 789  N N   . GLY A 1 108 ? 120.153 119.929 163.575 1.00 64.92 ? 151 GLY A N   1 
ATOM 790  C CA  . GLY A 1 108 ? 119.578 120.049 164.899 1.00 63.95 ? 151 GLY A CA  1 
ATOM 791  C C   . GLY A 1 108 ? 120.576 120.358 165.996 1.00 69.78 ? 151 GLY A C   1 
ATOM 792  O O   . GLY A 1 108 ? 120.223 120.981 167.002 1.00 68.16 ? 151 GLY A O   1 
ATOM 793  N N   . ALA A 1 109 ? 121.825 119.930 165.820 1.00 74.49 ? 152 ALA A N   1 
ATOM 794  C CA  . ALA A 1 109 ? 122.834 120.088 166.864 1.00 71.84 ? 152 ALA A CA  1 
ATOM 795  C C   . ALA A 1 109 ? 123.650 121.366 166.685 1.00 69.33 ? 152 ALA A C   1 
ATOM 796  O O   . ALA A 1 109 ? 123.660 122.231 167.565 1.00 69.92 ? 152 ALA A O   1 
ATOM 797  C CB  . ALA A 1 109 ? 123.754 118.862 166.890 1.00 75.10 ? 152 ALA A CB  1 
ATOM 798  N N   . SER A 1 110 ? 124.334 121.497 165.551 1.00 70.26 ? 153 SER A N   1 
ATOM 799  C CA  . SER A 1 110 ? 125.212 122.633 165.315 1.00 70.59 ? 153 SER A CA  1 
ATOM 800  C C   . SER A 1 110 ? 125.313 122.877 163.815 1.00 71.29 ? 153 SER A C   1 
ATOM 801  O O   . SER A 1 110 ? 124.659 122.210 163.010 1.00 75.59 ? 153 SER A O   1 
ATOM 802  C CB  . SER A 1 110 ? 126.592 122.400 165.937 1.00 68.84 ? 153 SER A CB  1 
ATOM 803  O OG  . SER A 1 110 ? 127.287 121.368 165.259 1.00 73.00 ? 153 SER A OG  1 
ATOM 804  N N   . ASP A 1 111 ? 126.143 123.849 163.447 1.00 67.88 ? 154 ASP A N   1 
ATOM 805  C CA  . ASP A 1 111 ? 126.314 124.203 162.046 1.00 66.07 ? 154 ASP A CA  1 
ATOM 806  C C   . ASP A 1 111 ? 126.997 123.076 161.283 1.00 66.98 ? 154 ASP A C   1 
ATOM 807  O O   . ASP A 1 111 ? 127.936 122.447 161.778 1.00 74.01 ? 154 ASP A O   1 
ATOM 808  C CB  . ASP A 1 111 ? 127.130 125.488 161.920 1.00 71.95 ? 154 ASP A CB  1 
ATOM 809  C CG  . ASP A 1 111 ? 126.352 126.717 162.344 1.00 74.69 ? 154 ASP A CG  1 
ATOM 810  O OD1 . ASP A 1 111 ? 125.471 126.592 163.220 1.00 74.82 ? 154 ASP A OD1 1 
ATOM 811  O OD2 . ASP A 1 111 ? 126.623 127.809 161.802 1.00 72.44 ? 154 ASP A OD2 1 
ATOM 812  N N   . VAL A 1 112 ? 126.516 122.822 160.069 1.00 59.07 ? 155 VAL A N   1 
ATOM 813  C CA  . VAL A 1 112 ? 127.091 121.822 159.179 1.00 57.09 ? 155 VAL A CA  1 
ATOM 814  C C   . VAL A 1 112 ? 127.397 122.493 157.849 1.00 54.48 ? 155 VAL A C   1 
ATOM 815  O O   . VAL A 1 112 ? 126.529 123.155 157.270 1.00 59.04 ? 155 VAL A O   1 
ATOM 816  C CB  . VAL A 1 112 ? 126.147 120.622 158.974 1.00 59.86 ? 155 VAL A CB  1 
ATOM 817  C CG1 . VAL A 1 112 ? 126.779 119.604 158.039 1.00 61.58 ? 155 VAL A CG1 1 
ATOM 818  C CG2 . VAL A 1 112 ? 125.801 119.982 160.309 1.00 62.50 ? 155 VAL A CG2 1 
ATOM 819  N N   . GLU A 1 113 ? 128.623 122.323 157.368 1.00 54.15 ? 156 GLU A N   1 
ATOM 820  C CA  . GLU A 1 113 ? 129.055 122.898 156.103 1.00 57.78 ? 156 GLU A CA  1 
ATOM 821  C C   . GLU A 1 113 ? 129.070 121.813 155.035 1.00 61.94 ? 156 GLU A C   1 
ATOM 822  O O   . GLU A 1 113 ? 129.684 120.758 155.222 1.00 67.10 ? 156 GLU A O   1 
ATOM 823  C CB  . GLU A 1 113 ? 130.440 123.533 156.236 1.00 64.05 ? 156 GLU A CB  1 
ATOM 824  C CG  . GLU A 1 113 ? 131.190 123.667 154.921 1.00 67.05 ? 156 GLU A CG  1 
ATOM 825  C CD  . GLU A 1 113 ? 131.865 125.016 154.769 1.00 68.01 ? 156 GLU A CD  1 
ATOM 826  O OE1 . GLU A 1 113 ? 132.526 125.463 155.730 1.00 66.74 ? 156 GLU A OE1 1 
ATOM 827  O OE2 . GLU A 1 113 ? 131.734 125.630 153.689 1.00 64.37 ? 156 GLU A OE2 1 
ATOM 828  N N   . VAL A 1 114 ? 128.392 122.076 153.921 1.00 49.70 ? 157 VAL A N   1 
ATOM 829  C CA  . VAL A 1 114 ? 128.266 121.126 152.823 1.00 37.92 ? 157 VAL A CA  1 
ATOM 830  C C   . VAL A 1 114 ? 128.850 121.757 151.570 1.00 42.34 ? 157 VAL A C   1 
ATOM 831  O O   . VAL A 1 114 ? 128.494 122.886 151.214 1.00 51.60 ? 157 VAL A O   1 
ATOM 832  C CB  . VAL A 1 114 ? 126.801 120.717 152.594 1.00 42.26 ? 157 VAL A CB  1 
ATOM 833  C CG1 . VAL A 1 114 ? 126.691 119.813 151.382 1.00 47.56 ? 157 VAL A CG1 1 
ATOM 834  C CG2 . VAL A 1 114 ? 126.243 120.033 153.830 1.00 48.04 ? 157 VAL A CG2 1 
ATOM 835  N N   . SER A 1 115 ? 129.745 121.030 150.904 1.00 43.84 ? 158 SER A N   1 
ATOM 836  C CA  . SER A 1 115 ? 130.348 121.508 149.669 1.00 45.57 ? 158 SER A CA  1 
ATOM 837  C C   . SER A 1 115 ? 129.612 121.032 148.426 1.00 52.82 ? 158 SER A C   1 
ATOM 838  O O   . SER A 1 115 ? 129.718 121.676 147.376 1.00 57.83 ? 158 SER A O   1 
ATOM 839  C CB  . SER A 1 115 ? 131.812 121.067 149.589 1.00 52.61 ? 158 SER A CB  1 
ATOM 840  O OG  . SER A 1 115 ? 131.934 119.671 149.794 1.00 56.42 ? 158 SER A OG  1 
ATOM 841  N N   . TRP A 1 116 ? 128.873 119.928 148.518 1.00 55.26 ? 159 TRP A N   1 
ATOM 842  C CA  . TRP A 1 116 ? 128.105 119.424 147.390 1.00 50.44 ? 159 TRP A CA  1 
ATOM 843  C C   . TRP A 1 116 ? 127.002 118.515 147.908 1.00 45.97 ? 159 TRP A C   1 
ATOM 844  O O   . TRP A 1 116 ? 127.183 117.799 148.895 1.00 56.31 ? 159 TRP A O   1 
ATOM 845  C CB  . TRP A 1 116 ? 128.989 118.668 146.393 1.00 49.92 ? 159 TRP A CB  1 
ATOM 846  C CG  . TRP A 1 116 ? 128.485 118.746 144.993 1.00 44.53 ? 159 TRP A CG  1 
ATOM 847  C CD1 . TRP A 1 116 ? 127.807 117.781 144.311 1.00 46.80 ? 159 TRP A CD1 1 
ATOM 848  C CD2 . TRP A 1 116 ? 128.614 119.855 144.099 1.00 43.50 ? 159 TRP A CD2 1 
ATOM 849  N NE1 . TRP A 1 116 ? 127.504 118.221 143.046 1.00 48.05 ? 159 TRP A NE1 1 
ATOM 850  C CE2 . TRP A 1 116 ? 127.990 119.492 142.891 1.00 48.24 ? 159 TRP A CE2 1 
ATOM 851  C CE3 . TRP A 1 116 ? 129.197 121.121 144.202 1.00 49.27 ? 159 TRP A CE3 1 
ATOM 852  C CZ2 . TRP A 1 116 ? 127.932 120.348 141.796 1.00 52.78 ? 159 TRP A CZ2 1 
ATOM 853  C CZ3 . TRP A 1 116 ? 129.139 121.968 143.114 1.00 51.99 ? 159 TRP A CZ3 1 
ATOM 854  C CH2 . TRP A 1 116 ? 128.512 121.578 141.926 1.00 52.19 ? 159 TRP A CH2 1 
ATOM 855  N N   . PHE A 1 117 ? 125.863 118.549 147.226 1.00 38.64 ? 160 PHE A N   1 
ATOM 856  C CA  . PHE A 1 117 ? 124.721 117.709 147.552 1.00 40.42 ? 160 PHE A CA  1 
ATOM 857  C C   . PHE A 1 117 ? 124.505 116.691 146.442 1.00 52.44 ? 160 PHE A C   1 
ATOM 858  O O   . PHE A 1 117 ? 124.645 117.012 145.258 1.00 54.51 ? 160 PHE A O   1 
ATOM 859  C CB  . PHE A 1 117 ? 123.457 118.547 147.744 1.00 41.33 ? 160 PHE A CB  1 
ATOM 860  C CG  . PHE A 1 117 ? 123.324 119.145 149.114 1.00 49.31 ? 160 PHE A CG  1 
ATOM 861  C CD1 . PHE A 1 117 ? 122.926 118.371 150.189 1.00 54.72 ? 160 PHE A CD1 1 
ATOM 862  C CD2 . PHE A 1 117 ? 123.581 120.488 149.325 1.00 45.84 ? 160 PHE A CD2 1 
ATOM 863  C CE1 . PHE A 1 117 ? 122.799 118.924 151.448 1.00 47.98 ? 160 PHE A CE1 1 
ATOM 864  C CE2 . PHE A 1 117 ? 123.451 121.045 150.581 1.00 40.61 ? 160 PHE A CE2 1 
ATOM 865  C CZ  . PHE A 1 117 ? 123.061 120.262 151.643 1.00 38.26 ? 160 PHE A CZ  1 
ATOM 866  N N   . ILE A 1 118 ? 124.166 115.463 146.827 1.00 56.40 ? 161 ILE A N   1 
ATOM 867  C CA  . ILE A 1 118 ? 124.001 114.358 145.892 1.00 44.93 ? 161 ILE A CA  1 
ATOM 868  C C   . ILE A 1 118 ? 122.642 113.717 146.123 1.00 46.37 ? 161 ILE A C   1 
ATOM 869  O O   . ILE A 1 118 ? 122.277 113.418 147.266 1.00 56.42 ? 161 ILE A O   1 
ATOM 870  C CB  . ILE A 1 118 ? 125.124 113.313 146.041 1.00 49.23 ? 161 ILE A CB  1 
ATOM 871  C CG1 . ILE A 1 118 ? 126.422 113.835 145.428 1.00 51.56 ? 161 ILE A CG1 1 
ATOM 872  C CG2 . ILE A 1 118 ? 124.727 111.999 145.391 1.00 50.15 ? 161 ILE A CG2 1 
ATOM 873  C CD1 . ILE A 1 118 ? 127.643 113.038 145.820 1.00 54.46 ? 161 ILE A CD1 1 
ATOM 874  N N   . GLY A 1 119 ? 121.894 113.510 145.041 1.00 48.81 ? 162 GLY A N   1 
ATOM 875  C CA  . GLY A 1 119 ? 120.648 112.778 145.111 1.00 50.25 ? 162 GLY A CA  1 
ATOM 876  C C   . GLY A 1 119 ? 120.416 111.999 143.833 1.00 56.12 ? 162 GLY A C   1 
ATOM 877  O O   . GLY A 1 119 ? 121.070 112.226 142.812 1.00 56.83 ? 162 GLY A O   1 
ATOM 878  N N   . SER A 1 120 ? 119.486 111.045 143.917 1.00 55.02 ? 163 SER A N   1 
ATOM 879  C CA  . SER A 1 120 ? 118.949 110.334 142.756 1.00 55.72 ? 163 SER A CA  1 
ATOM 880  C C   . SER A 1 120 ? 120.061 109.653 141.949 1.00 59.73 ? 163 SER A C   1 
ATOM 881  O O   . SER A 1 120 ? 120.334 109.987 140.794 1.00 62.40 ? 163 SER A O   1 
ATOM 882  C CB  . SER A 1 120 ? 118.131 111.285 141.874 1.00 58.16 ? 163 SER A CB  1 
ATOM 883  O OG  . SER A 1 120 ? 116.964 111.725 142.548 1.00 61.44 ? 163 SER A OG  1 
ATOM 884  N N   . VAL A 1 121 ? 120.701 108.682 142.595 1.00 49.54 ? 164 VAL A N   1 
ATOM 885  C CA  . VAL A 1 121 ? 121.715 107.846 141.960 1.00 39.85 ? 164 VAL A CA  1 
ATOM 886  C C   . VAL A 1 121 ? 121.052 106.567 141.470 1.00 48.20 ? 164 VAL A C   1 
ATOM 887  O O   . VAL A 1 121 ? 120.356 105.888 142.236 1.00 55.11 ? 164 VAL A O   1 
ATOM 888  C CB  . VAL A 1 121 ? 122.867 107.531 142.928 1.00 48.54 ? 164 VAL A CB  1 
ATOM 889  C CG1 . VAL A 1 121 ? 124.102 107.102 142.157 1.00 49.82 ? 164 VAL A CG1 1 
ATOM 890  C CG2 . VAL A 1 121 ? 123.172 108.740 143.799 1.00 55.14 ? 164 VAL A CG2 1 
ATOM 891  N N   . TYR A 1 122 ? 121.262 106.237 140.197 1.00 46.20 ? 165 TYR A N   1 
ATOM 892  C CA  . TYR A 1 122 ? 120.671 105.050 139.594 1.00 41.44 ? 165 TYR A CA  1 
ATOM 893  C C   . TYR A 1 122 ? 121.694 104.358 138.706 1.00 47.20 ? 165 TYR A C   1 
ATOM 894  O O   . TYR A 1 122 ? 122.409 105.013 137.943 1.00 49.92 ? 165 TYR A O   1 
ATOM 895  C CB  . TYR A 1 122 ? 119.423 105.400 138.776 1.00 44.97 ? 165 TYR A CB  1 
ATOM 896  C CG  . TYR A 1 122 ? 118.317 106.024 139.592 1.00 43.71 ? 165 TYR A CG  1 
ATOM 897  C CD1 . TYR A 1 122 ? 117.633 105.287 140.545 1.00 48.64 ? 165 TYR A CD1 1 
ATOM 898  C CD2 . TYR A 1 122 ? 117.958 107.350 139.409 1.00 48.17 ? 165 TYR A CD2 1 
ATOM 899  C CE1 . TYR A 1 122 ? 116.624 105.853 141.294 1.00 49.22 ? 165 TYR A CE1 1 
ATOM 900  C CE2 . TYR A 1 122 ? 116.949 107.924 140.153 1.00 49.61 ? 165 TYR A CE2 1 
ATOM 901  C CZ  . TYR A 1 122 ? 116.286 107.171 141.095 1.00 49.46 ? 165 TYR A CZ  1 
ATOM 902  O OH  . TYR A 1 122 ? 115.279 107.738 141.839 1.00 54.42 ? 165 TYR A OH  1 
ATOM 903  N N   . GLU A 1 123 ? 121.747 103.032 138.803 1.00 57.27 ? 166 GLU A N   1 
ATOM 904  C CA  . GLU A 1 123 ? 122.685 102.209 138.050 1.00 55.72 ? 166 GLU A CA  1 
ATOM 905  C C   . GLU A 1 123 ? 121.907 101.266 137.145 1.00 57.40 ? 166 GLU A C   1 
ATOM 906  O O   . GLU A 1 123 ? 120.980 100.591 137.601 1.00 57.02 ? 166 GLU A O   1 
ATOM 907  C CB  . GLU A 1 123 ? 123.592 101.416 138.994 1.00 47.91 ? 166 GLU A CB  1 
ATOM 908  C CG  . GLU A 1 123 ? 124.355 100.288 138.331 1.00 49.12 ? 166 GLU A CG  1 
ATOM 909  C CD  . GLU A 1 123 ? 125.778 100.180 138.834 1.00 58.44 ? 166 GLU A CD  1 
ATOM 910  O OE1 . GLU A 1 123 ? 126.082 100.768 139.892 1.00 60.82 ? 166 GLU A OE1 1 
ATOM 911  O OE2 . GLU A 1 123 ? 126.592 99.500  138.176 1.00 60.34 ? 166 GLU A OE2 1 
ATOM 912  N N   . LEU A 1 124 ? 122.291 101.214 135.872 1.00 48.66 ? 167 LEU A N   1 
ATOM 913  C CA  . LEU A 1 124 ? 121.547 100.437 134.890 1.00 38.57 ? 167 LEU A CA  1 
ATOM 914  C C   . LEU A 1 124 ? 121.670 98.939  135.153 1.00 37.43 ? 167 LEU A C   1 
ATOM 915  O O   . LEU A 1 124 ? 122.685 98.451  135.655 1.00 42.82 ? 167 LEU A O   1 
ATOM 916  C CB  . LEU A 1 124 ? 122.035 100.756 133.478 1.00 39.29 ? 167 LEU A CB  1 
ATOM 917  C CG  . LEU A 1 124 ? 120.998 100.638 132.361 1.00 39.36 ? 167 LEU A CG  1 
ATOM 918  C CD1 . LEU A 1 124 ? 119.710 101.349 132.743 1.00 48.95 ? 167 LEU A CD1 1 
ATOM 919  C CD2 . LEU A 1 124 ? 121.550 101.191 131.062 1.00 42.14 ? 167 LEU A CD2 1 
ATOM 920  N N   . TYR A 1 125 ? 120.614 98.211  134.803 1.00 33.05 ? 168 TYR A N   1 
ATOM 921  C CA  . TYR A 1 125 ? 120.548 96.768  134.968 1.00 33.95 ? 168 TYR A CA  1 
ATOM 922  C C   . TYR A 1 125 ? 120.299 96.107  133.619 1.00 44.72 ? 168 TYR A C   1 
ATOM 923  O O   . TYR A 1 125 ? 119.607 96.658  132.758 1.00 49.92 ? 168 TYR A O   1 
ATOM 924  C CB  . TYR A 1 125 ? 119.441 96.377  135.956 1.00 40.56 ? 168 TYR A CB  1 
ATOM 925  C CG  . TYR A 1 125 ? 119.155 94.894  136.033 1.00 35.83 ? 168 TYR A CG  1 
ATOM 926  C CD1 . TYR A 1 125 ? 119.919 94.061  136.838 1.00 38.72 ? 168 TYR A CD1 1 
ATOM 927  C CD2 . TYR A 1 125 ? 118.110 94.329  135.314 1.00 38.93 ? 168 TYR A CD2 1 
ATOM 928  C CE1 . TYR A 1 125 ? 119.659 92.709  136.916 1.00 36.29 ? 168 TYR A CE1 1 
ATOM 929  C CE2 . TYR A 1 125 ? 117.843 92.977  135.387 1.00 46.68 ? 168 TYR A CE2 1 
ATOM 930  C CZ  . TYR A 1 125 ? 118.620 92.172  136.189 1.00 42.35 ? 168 TYR A CZ  1 
ATOM 931  O OH  . TYR A 1 125 ? 118.357 90.825  136.265 1.00 46.63 ? 168 TYR A OH  1 
ATOM 932  N N   . GLY A 1 126 ? 120.869 94.919  133.444 1.00 47.14 ? 169 GLY A N   1 
ATOM 933  C CA  . GLY A 1 126 ? 120.693 94.159  132.224 1.00 40.13 ? 169 GLY A CA  1 
ATOM 934  C C   . GLY A 1 126 ? 121.664 94.473  131.110 1.00 39.48 ? 169 GLY A C   1 
ATOM 935  O O   . GLY A 1 126 ? 121.490 93.956  130.001 1.00 48.87 ? 169 GLY A O   1 
ATOM 936  N N   . ALA A 1 127 ? 122.673 95.301  131.361 1.00 48.35 ? 170 ALA A N   1 
ATOM 937  C CA  . ALA A 1 127 ? 123.648 95.627  130.331 1.00 49.82 ? 170 ALA A CA  1 
ATOM 938  C C   . ALA A 1 127 ? 124.477 94.400  129.973 1.00 52.65 ? 170 ALA A C   1 
ATOM 939  O O   . ALA A 1 127 ? 124.846 93.605  130.841 1.00 50.62 ? 170 ALA A O   1 
ATOM 940  C CB  . ALA A 1 127 ? 124.557 96.761  130.800 1.00 49.79 ? 170 ALA A CB  1 
ATOM 941  N N   . GLU A 1 128 ? 124.770 94.247  128.682 1.00 60.37 ? 171 GLU A N   1 
ATOM 942  C CA  . GLU A 1 128 ? 125.485 93.079  128.185 1.00 57.40 ? 171 GLU A CA  1 
ATOM 943  C C   . GLU A 1 128 ? 126.866 93.426  127.643 1.00 59.70 ? 171 GLU A C   1 
ATOM 944  O O   . GLU A 1 128 ? 127.868 92.887  128.119 1.00 66.11 ? 171 GLU A O   1 
ATOM 945  C CB  . GLU A 1 128 ? 124.650 92.382  127.103 1.00 60.82 ? 171 GLU A CB  1 
ATOM 946  C CG  . GLU A 1 128 ? 123.924 91.138  127.583 1.00 67.38 ? 171 GLU A CG  1 
ATOM 947  C CD  . GLU A 1 128 ? 122.797 90.729  126.655 1.00 71.61 ? 171 GLU A CD  1 
ATOM 948  O OE1 . GLU A 1 128 ? 121.867 91.538  126.454 1.00 68.32 ? 171 GLU A OE1 1 
ATOM 949  O OE2 . GLU A 1 128 ? 122.841 89.598  126.126 1.00 68.28 ? 171 GLU A OE2 1 
ATOM 950  N N   . ASP A 1 129 ? 126.950 94.317  126.656 1.00 52.12 ? 172 ASP A N   1 
ATOM 951  C CA  . ASP A 1 129 ? 128.243 94.652  126.064 1.00 52.76 ? 172 ASP A CA  1 
ATOM 952  C C   . ASP A 1 129 ? 128.460 96.134  125.806 1.00 59.10 ? 172 ASP A C   1 
ATOM 953  O O   . ASP A 1 129 ? 129.610 96.530  125.593 1.00 63.76 ? 172 ASP A O   1 
ATOM 954  C CB  . ASP A 1 129 ? 128.439 93.890  124.748 1.00 57.16 ? 172 ASP A CB  1 
ATOM 955  C CG  . ASP A 1 129 ? 127.361 94.200  123.728 1.00 63.66 ? 172 ASP A CG  1 
ATOM 956  O OD1 . ASP A 1 129 ? 126.171 94.224  124.106 1.00 64.21 ? 172 ASP A OD1 1 
ATOM 957  O OD2 . ASP A 1 129 ? 127.704 94.417  122.547 1.00 62.74 ? 172 ASP A OD2 1 
ATOM 958  N N   . ARG A 1 130 ? 127.425 96.970  125.814 1.00 56.65 ? 173 ARG A N   1 
ATOM 959  C CA  . ARG A 1 130 ? 127.606 98.393  125.571 1.00 53.14 ? 173 ARG A CA  1 
ATOM 960  C C   . ARG A 1 130 ? 126.414 99.149  126.134 1.00 49.93 ? 173 ARG A C   1 
ATOM 961  O O   . ARG A 1 130 ? 125.319 98.600  126.280 1.00 54.07 ? 173 ARG A O   1 
ATOM 962  C CB  . ARG A 1 130 ? 127.776 98.695  124.079 1.00 53.81 ? 173 ARG A CB  1 
ATOM 963  C CG  . ARG A 1 130 ? 126.663 98.149  123.203 1.00 54.00 ? 173 ARG A CG  1 
ATOM 964  C CD  . ARG A 1 130 ? 127.213 97.578  121.907 1.00 53.31 ? 173 ARG A CD  1 
ATOM 965  N NE  . ARG A 1 130 ? 126.234 97.618  120.828 1.00 54.08 ? 173 ARG A NE  1 
ATOM 966  C CZ  . ARG A 1 130 ? 125.223 96.770  120.700 1.00 53.25 ? 173 ARG A CZ  1 
ATOM 967  N NH1 . ARG A 1 130 ? 125.021 95.798  121.573 1.00 51.78 ? 173 ARG A NH1 1 
ATOM 968  N NH2 . ARG A 1 130 ? 124.394 96.900  119.669 1.00 53.99 ? 173 ARG A NH2 1 
ATOM 969  N N   . ILE A 1 131 ? 126.647 100.419 126.451 1.00 42.21 ? 174 ILE A N   1 
ATOM 970  C CA  . ILE A 1 131 ? 125.610 101.328 126.921 1.00 34.67 ? 174 ILE A CA  1 
ATOM 971  C C   . ILE A 1 131 ? 125.756 102.643 126.169 1.00 44.59 ? 174 ILE A C   1 
ATOM 972  O O   . ILE A 1 131 ? 126.854 103.206 126.107 1.00 52.26 ? 174 ILE A O   1 
ATOM 973  C CB  . ILE A 1 131 ? 125.696 101.559 128.441 1.00 30.41 ? 174 ILE A CB  1 
ATOM 974  C CG1 . ILE A 1 131 ? 125.347 100.278 129.196 1.00 40.96 ? 174 ILE A CG1 1 
ATOM 975  C CG2 . ILE A 1 131 ? 124.775 102.688 128.862 1.00 42.80 ? 174 ILE A CG2 1 
ATOM 976  C CD1 . ILE A 1 131 ? 125.871 100.246 130.611 1.00 47.52 ? 174 ILE A CD1 1 
ATOM 977  N N   . TRP A 1 132 ? 124.659 103.125 125.596 1.00 37.97 ? 175 TRP A N   1 
ATOM 978  C CA  . TRP A 1 132 ? 124.634 104.404 124.901 1.00 33.00 ? 175 TRP A CA  1 
ATOM 979  C C   . TRP A 1 132 ? 124.031 105.462 125.813 1.00 44.12 ? 175 TRP A C   1 
ATOM 980  O O   . TRP A 1 132 ? 123.023 105.217 126.482 1.00 52.78 ? 175 TRP A O   1 
ATOM 981  C CB  . TRP A 1 132 ? 123.832 104.311 123.604 1.00 39.45 ? 175 TRP A CB  1 
ATOM 982  C CG  . TRP A 1 132 ? 124.591 103.701 122.474 1.00 33.14 ? 175 TRP A CG  1 
ATOM 983  C CD1 . TRP A 1 132 ? 124.726 102.374 122.201 1.00 37.78 ? 175 TRP A CD1 1 
ATOM 984  C CD2 . TRP A 1 132 ? 125.321 104.396 121.460 1.00 38.74 ? 175 TRP A CD2 1 
ATOM 985  N NE1 . TRP A 1 132 ? 125.496 102.197 121.080 1.00 39.24 ? 175 TRP A NE1 1 
ATOM 986  C CE2 . TRP A 1 132 ? 125.874 103.425 120.605 1.00 35.99 ? 175 TRP A CE2 1 
ATOM 987  C CE3 . TRP A 1 132 ? 125.562 105.745 121.192 1.00 45.94 ? 175 TRP A CE3 1 
ATOM 988  C CZ2 . TRP A 1 132 ? 126.652 103.760 119.503 1.00 39.45 ? 175 TRP A CZ2 1 
ATOM 989  C CZ3 . TRP A 1 132 ? 126.335 106.075 120.098 1.00 44.77 ? 175 TRP A CZ3 1 
ATOM 990  C CH2 . TRP A 1 132 ? 126.871 105.087 119.267 1.00 44.18 ? 175 TRP A CH2 1 
ATOM 991  N N   . SER A 1 133 ? 124.650 106.639 125.837 1.00 46.62 ? 176 SER A N   1 
ATOM 992  C CA  . SER A 1 133 ? 124.281 107.675 126.788 1.00 45.35 ? 176 SER A CA  1 
ATOM 993  C C   . SER A 1 133 ? 124.072 109.007 126.084 1.00 51.02 ? 176 SER A C   1 
ATOM 994  O O   . SER A 1 133 ? 124.750 109.326 125.105 1.00 53.49 ? 176 SER A O   1 
ATOM 995  C CB  . SER A 1 133 ? 125.348 107.836 127.878 1.00 55.69 ? 176 SER A CB  1 
ATOM 996  O OG  . SER A 1 133 ? 126.385 108.702 127.451 1.00 59.77 ? 176 SER A OG  1 
ATOM 997  N N   . TYR A 1 134 ? 123.124 109.782 126.605 1.00 57.60 ? 177 TYR A N   1 
ATOM 998  C CA  . TYR A 1 134 ? 122.882 111.152 126.174 1.00 54.99 ? 177 TYR A CA  1 
ATOM 999  C C   . TYR A 1 134 ? 123.414 112.107 127.232 1.00 51.56 ? 177 TYR A C   1 
ATOM 1000 O O   . TYR A 1 134 ? 123.093 111.967 128.416 1.00 53.72 ? 177 TYR A O   1 
ATOM 1001 C CB  . TYR A 1 134 ? 121.392 111.413 125.941 1.00 54.43 ? 177 TYR A CB  1 
ATOM 1002 C CG  . TYR A 1 134 ? 121.119 112.757 125.304 1.00 58.69 ? 177 TYR A CG  1 
ATOM 1003 C CD1 . TYR A 1 134 ? 121.680 113.091 124.080 1.00 54.58 ? 177 TYR A CD1 1 
ATOM 1004 C CD2 . TYR A 1 134 ? 120.324 113.701 125.939 1.00 55.40 ? 177 TYR A CD2 1 
ATOM 1005 C CE1 . TYR A 1 134 ? 121.441 114.318 123.496 1.00 51.22 ? 177 TYR A CE1 1 
ATOM 1006 C CE2 . TYR A 1 134 ? 120.083 114.934 125.363 1.00 54.23 ? 177 TYR A CE2 1 
ATOM 1007 C CZ  . TYR A 1 134 ? 120.646 115.236 124.142 1.00 54.54 ? 177 TYR A CZ  1 
ATOM 1008 O OH  . TYR A 1 134 ? 120.410 116.460 123.562 1.00 58.18 ? 177 TYR A OH  1 
ATOM 1009 N N   . ASN A 1 135 ? 124.219 113.075 126.805 1.00 52.07 ? 178 ASN A N   1 
ATOM 1010 C CA  . ASN A 1 135 ? 124.861 114.021 127.708 1.00 50.38 ? 178 ASN A CA  1 
ATOM 1011 C C   . ASN A 1 135 ? 124.316 115.416 127.444 1.00 54.80 ? 178 ASN A C   1 
ATOM 1012 O O   . ASN A 1 135 ? 124.409 115.919 126.320 1.00 54.34 ? 178 ASN A O   1 
ATOM 1013 C CB  . ASN A 1 135 ? 126.380 113.997 127.532 1.00 50.30 ? 178 ASN A CB  1 
ATOM 1014 C CG  . ASN A 1 135 ? 126.942 112.593 127.539 1.00 55.83 ? 178 ASN A CG  1 
ATOM 1015 O OD1 . ASN A 1 135 ? 127.008 111.944 128.581 1.00 55.16 ? 178 ASN A OD1 1 
ATOM 1016 N ND2 . ASN A 1 135 ? 127.354 112.115 126.371 1.00 55.63 ? 178 ASN A ND2 1 
ATOM 1017 N N   . GLY A 1 136 ? 123.748 116.036 128.481 1.00 58.31 ? 179 GLY A N   1 
ATOM 1018 C CA  . GLY A 1 136 ? 123.296 117.411 128.348 1.00 58.86 ? 179 GLY A CA  1 
ATOM 1019 C C   . GLY A 1 136 ? 124.439 118.369 128.075 1.00 59.05 ? 179 GLY A C   1 
ATOM 1020 O O   . GLY A 1 136 ? 124.315 119.283 127.257 1.00 59.71 ? 179 GLY A O   1 
ATOM 1021 N N   . GLY A 1 137 ? 125.563 118.174 128.758 1.00 49.43 ? 180 GLY A N   1 
ATOM 1022 C CA  . GLY A 1 137 ? 126.765 118.921 128.469 1.00 48.51 ? 180 GLY A CA  1 
ATOM 1023 C C   . GLY A 1 137 ? 126.655 120.398 128.806 1.00 45.77 ? 180 GLY A C   1 
ATOM 1024 O O   . GLY A 1 137 ? 125.862 120.830 129.646 1.00 54.05 ? 180 GLY A O   1 
ATOM 1025 N N   . GLY A 1 138 ? 127.483 121.179 128.121 1.00 40.37 ? 181 GLY A N   1 
ATOM 1026 C CA  . GLY A 1 138 ? 127.548 122.606 128.348 1.00 44.98 ? 181 GLY A CA  1 
ATOM 1027 C C   . GLY A 1 138 ? 128.973 123.088 128.509 1.00 49.97 ? 181 GLY A C   1 
ATOM 1028 O O   . GLY A 1 138 ? 129.285 124.245 128.213 1.00 56.67 ? 181 GLY A O   1 
ATOM 1029 N N   . GLU A 1 139 ? 129.850 122.202 128.980 1.00 45.20 ? 182 GLU A N   1 
ATOM 1030 C CA  . GLU A 1 139 ? 131.243 122.540 129.223 1.00 41.19 ? 182 GLU A CA  1 
ATOM 1031 C C   . GLU A 1 139 ? 132.218 121.787 128.331 1.00 47.72 ? 182 GLU A C   1 
ATOM 1032 O O   . GLU A 1 139 ? 133.412 122.104 128.348 1.00 56.07 ? 182 GLU A O   1 
ATOM 1033 C CB  . GLU A 1 139 ? 131.604 122.271 130.690 1.00 50.30 ? 182 GLU A CB  1 
ATOM 1034 C CG  . GLU A 1 139 ? 132.053 120.847 130.956 1.00 53.84 ? 182 GLU A CG  1 
ATOM 1035 C CD  . GLU A 1 139 ? 130.901 119.866 130.956 1.00 58.51 ? 182 GLU A CD  1 
ATOM 1036 O OE1 . GLU A 1 139 ? 129.750 120.295 131.183 1.00 60.82 ? 182 GLU A OE1 1 
ATOM 1037 O OE2 . GLU A 1 139 ? 131.145 118.665 130.721 1.00 58.05 ? 182 GLU A OE2 1 
ATOM 1038 N N   . GLY A 1 140 ? 131.749 120.815 127.554 1.00 50.87 ? 183 GLY A N   1 
ATOM 1039 C CA  . GLY A 1 140 ? 132.620 119.994 126.748 1.00 49.86 ? 183 GLY A CA  1 
ATOM 1040 C C   . GLY A 1 140 ? 133.307 120.786 125.659 1.00 52.91 ? 183 GLY A C   1 
ATOM 1041 O O   . GLY A 1 140 ? 132.974 121.948 125.402 1.00 58.40 ? 183 GLY A O   1 
ATOM 1042 N N   . PRO A 1 141 ? 134.298 120.178 125.008 1.00 43.16 ? 184 PRO A N   1 
ATOM 1043 C CA  . PRO A 1 141 ? 134.975 120.859 123.899 1.00 48.89 ? 184 PRO A CA  1 
ATOM 1044 C C   . PRO A 1 141 ? 133.976 121.265 122.827 1.00 49.50 ? 184 PRO A C   1 
ATOM 1045 O O   . PRO A 1 141 ? 133.009 120.552 122.551 1.00 55.87 ? 184 PRO A O   1 
ATOM 1046 C CB  . PRO A 1 141 ? 135.965 119.808 123.391 1.00 48.97 ? 184 PRO A CB  1 
ATOM 1047 C CG  . PRO A 1 141 ? 136.238 118.960 124.585 1.00 45.99 ? 184 PRO A CG  1 
ATOM 1048 C CD  . PRO A 1 141 ? 134.947 118.902 125.351 1.00 44.47 ? 184 PRO A CD  1 
ATOM 1049 N N   . MET A 1 142 ? 134.219 122.431 122.229 1.00 48.26 ? 185 MET A N   1 
ATOM 1050 C CA  . MET A 1 142 ? 133.208 123.134 121.449 1.00 50.65 ? 185 MET A CA  1 
ATOM 1051 C C   . MET A 1 142 ? 132.633 122.302 120.310 1.00 56.48 ? 185 MET A C   1 
ATOM 1052 O O   . MET A 1 142 ? 131.453 121.943 120.339 1.00 60.76 ? 185 MET A O   1 
ATOM 1053 C CB  . MET A 1 142 ? 133.791 124.433 120.889 1.00 54.44 ? 185 MET A CB  1 
ATOM 1054 C CG  . MET A 1 142 ? 133.358 125.681 121.636 1.00 53.69 ? 185 MET A CG  1 
ATOM 1055 S SD  . MET A 1 142 ? 133.451 127.162 120.616 1.00 62.49 ? 185 MET A SD  1 
ATOM 1056 C CE  . MET A 1 142 ? 135.209 127.497 120.669 1.00 53.84 ? 185 MET A CE  1 
ATOM 1057 N N   . HIS A 1 143 ? 133.452 121.972 119.315 1.00 52.24 ? 186 HIS A N   1 
ATOM 1058 C CA  . HIS A 1 143 ? 132.956 121.382 118.078 1.00 48.61 ? 186 HIS A CA  1 
ATOM 1059 C C   . HIS A 1 143 ? 133.303 119.907 117.934 1.00 56.56 ? 186 HIS A C   1 
ATOM 1060 O O   . HIS A 1 143 ? 133.136 119.350 116.844 1.00 64.61 ? 186 HIS A O   1 
ATOM 1061 C CB  . HIS A 1 143 ? 133.498 122.157 116.877 1.00 50.05 ? 186 HIS A CB  1 
ATOM 1062 C CG  . HIS A 1 143 ? 133.042 123.580 116.819 1.00 49.85 ? 186 HIS A CG  1 
ATOM 1063 N ND1 . HIS A 1 143 ? 133.854 124.636 117.173 1.00 51.92 ? 186 HIS A ND1 1 
ATOM 1064 C CD2 . HIS A 1 143 ? 131.860 124.124 116.447 1.00 54.10 ? 186 HIS A CD2 1 
ATOM 1065 C CE1 . HIS A 1 143 ? 133.191 125.768 117.023 1.00 54.20 ? 186 HIS A CE1 1 
ATOM 1066 N NE2 . HIS A 1 143 ? 131.978 125.485 116.583 1.00 56.66 ? 186 HIS A NE2 1 
ATOM 1067 N N   . TYR A 1 144 ? 133.781 119.255 118.997 1.00 46.22 ? 187 TYR A N   1 
ATOM 1068 C CA  . TYR A 1 144 ? 134.314 117.910 118.825 1.00 40.90 ? 187 TYR A CA  1 
ATOM 1069 C C   . TYR A 1 144 ? 133.896 116.944 119.929 1.00 44.48 ? 187 TYR A C   1 
ATOM 1070 O O   . TYR A 1 144 ? 134.573 115.929 120.134 1.00 51.44 ? 187 TYR A O   1 
ATOM 1071 C CB  . TYR A 1 144 ? 135.840 117.960 118.734 1.00 45.29 ? 187 TYR A CB  1 
ATOM 1072 C CG  . TYR A 1 144 ? 136.342 118.764 117.559 1.00 45.72 ? 187 TYR A CG  1 
ATOM 1073 C CD1 . TYR A 1 144 ? 136.880 120.029 117.740 1.00 49.45 ? 187 TYR A CD1 1 
ATOM 1074 C CD2 . TYR A 1 144 ? 136.269 118.262 116.268 1.00 45.84 ? 187 TYR A CD2 1 
ATOM 1075 C CE1 . TYR A 1 144 ? 137.337 120.769 116.669 1.00 50.68 ? 187 TYR A CE1 1 
ATOM 1076 C CE2 . TYR A 1 144 ? 136.723 118.995 115.191 1.00 43.95 ? 187 TYR A CE2 1 
ATOM 1077 C CZ  . TYR A 1 144 ? 137.255 120.247 115.397 1.00 48.48 ? 187 TYR A CZ  1 
ATOM 1078 O OH  . TYR A 1 144 ? 137.710 120.982 114.327 1.00 56.63 ? 187 TYR A OH  1 
ATOM 1079 N N   . TYR A 1 145 ? 132.809 117.218 120.644 1.00 38.37 ? 188 TYR A N   1 
ATOM 1080 C CA  . TYR A 1 145 ? 132.288 116.292 121.645 1.00 38.26 ? 188 TYR A CA  1 
ATOM 1081 C C   . TYR A 1 145 ? 130.855 115.936 121.274 1.00 47.95 ? 188 TYR A C   1 
ATOM 1082 O O   . TYR A 1 145 ? 129.968 116.795 121.308 1.00 53.52 ? 188 TYR A O   1 
ATOM 1083 C CB  . TYR A 1 145 ? 132.360 116.883 123.050 1.00 39.91 ? 188 TYR A CB  1 
ATOM 1084 C CG  . TYR A 1 145 ? 132.233 115.839 124.134 1.00 41.66 ? 188 TYR A CG  1 
ATOM 1085 C CD1 . TYR A 1 145 ? 133.328 115.085 124.529 1.00 49.36 ? 188 TYR A CD1 1 
ATOM 1086 C CD2 . TYR A 1 145 ? 131.015 115.597 124.752 1.00 43.36 ? 188 TYR A CD2 1 
ATOM 1087 C CE1 . TYR A 1 145 ? 133.216 114.126 125.515 1.00 47.17 ? 188 TYR A CE1 1 
ATOM 1088 C CE2 . TYR A 1 145 ? 130.894 114.639 125.738 1.00 42.49 ? 188 TYR A CE2 1 
ATOM 1089 C CZ  . TYR A 1 145 ? 131.997 113.907 126.115 1.00 45.27 ? 188 TYR A CZ  1 
ATOM 1090 O OH  . TYR A 1 145 ? 131.881 112.952 127.098 1.00 49.57 ? 188 TYR A OH  1 
ATOM 1091 N N   . ASP A 1 146 ? 130.635 114.673 120.923 1.00 51.42 ? 189 ASP A N   1 
ATOM 1092 C CA  . ASP A 1 146 ? 129.304 114.218 120.555 1.00 48.32 ? 189 ASP A CA  1 
ATOM 1093 C C   . ASP A 1 146 ? 128.379 114.245 121.764 1.00 47.20 ? 189 ASP A C   1 
ATOM 1094 O O   . ASP A 1 146 ? 128.779 113.907 122.881 1.00 54.43 ? 189 ASP A O   1 
ATOM 1095 C CB  . ASP A 1 146 ? 129.367 112.805 119.979 1.00 51.64 ? 189 ASP A CB  1 
ATOM 1096 C CG  . ASP A 1 146 ? 130.506 112.626 119.000 1.00 57.13 ? 189 ASP A CG  1 
ATOM 1097 O OD1 . ASP A 1 146 ? 130.573 113.389 118.015 1.00 56.77 ? 189 ASP A OD1 1 
ATOM 1098 O OD2 . ASP A 1 146 ? 131.338 111.719 119.214 1.00 57.26 ? 189 ASP A OD2 1 
ATOM 1099 N N   . THR A 1 147 ? 127.132 114.651 121.535 1.00 42.16 ? 190 THR A N   1 
ATOM 1100 C CA  . THR A 1 147 ? 126.140 114.658 122.600 1.00 41.23 ? 190 THR A CA  1 
ATOM 1101 C C   . THR A 1 147 ? 125.645 113.262 122.947 1.00 50.66 ? 190 THR A C   1 
ATOM 1102 O O   . THR A 1 147 ? 124.960 113.099 123.962 1.00 56.98 ? 190 THR A O   1 
ATOM 1103 C CB  . THR A 1 147 ? 124.953 115.544 122.214 1.00 44.98 ? 190 THR A CB  1 
ATOM 1104 O OG1 . THR A 1 147 ? 124.129 115.765 123.363 1.00 45.26 ? 190 THR A OG1 1 
ATOM 1105 C CG2 . THR A 1 147 ? 124.127 114.883 121.122 1.00 51.58 ? 190 THR A CG2 1 
ATOM 1106 N N   . LEU A 1 148 ? 125.971 112.261 122.134 1.00 52.65 ? 191 LEU A N   1 
ATOM 1107 C CA  . LEU A 1 148 ? 125.649 110.868 122.407 1.00 46.86 ? 191 LEU A CA  1 
ATOM 1108 C C   . LEU A 1 148 ? 126.935 110.058 122.356 1.00 52.99 ? 191 LEU A C   1 
ATOM 1109 O O   . LEU A 1 148 ? 127.669 110.116 121.364 1.00 57.46 ? 191 LEU A O   1 
ATOM 1110 C CB  . LEU A 1 148 ? 124.631 110.332 121.400 1.00 42.69 ? 191 LEU A CB  1 
ATOM 1111 C CG  . LEU A 1 148 ? 123.165 110.529 121.786 1.00 47.00 ? 191 LEU A CG  1 
ATOM 1112 C CD1 . LEU A 1 148 ? 122.310 110.687 120.549 1.00 49.40 ? 191 LEU A CD1 1 
ATOM 1113 C CD2 . LEU A 1 148 ? 122.673 109.364 122.624 1.00 52.66 ? 191 LEU A CD2 1 
ATOM 1114 N N   . GLN A 1 149 ? 127.206 109.305 123.419 1.00 50.50 ? 192 GLN A N   1 
ATOM 1115 C CA  . GLN A 1 149 ? 128.472 108.606 123.570 1.00 42.65 ? 192 GLN A CA  1 
ATOM 1116 C C   . GLN A 1 149 ? 128.228 107.140 123.894 1.00 45.15 ? 192 GLN A C   1 
ATOM 1117 O O   . GLN A 1 149 ? 127.173 106.760 124.406 1.00 49.22 ? 192 GLN A O   1 
ATOM 1118 C CB  . GLN A 1 149 ? 129.334 109.250 124.661 1.00 38.15 ? 192 GLN A CB  1 
ATOM 1119 C CG  . GLN A 1 149 ? 129.779 110.660 124.334 1.00 37.09 ? 192 GLN A CG  1 
ATOM 1120 C CD  . GLN A 1 149 ? 131.178 110.707 123.768 1.00 44.94 ? 192 GLN A CD  1 
ATOM 1121 O OE1 . GLN A 1 149 ? 132.007 109.846 124.060 1.00 48.98 ? 192 GLN A OE1 1 
ATOM 1122 N NE2 . GLN A 1 149 ? 131.452 111.715 122.949 1.00 45.82 ? 192 GLN A NE2 1 
ATOM 1123 N N   . LYS A 1 150 ? 129.228 106.318 123.587 1.00 39.67 ? 193 LYS A N   1 
ATOM 1124 C CA  . LYS A 1 150 ? 129.170 104.879 123.802 1.00 37.76 ? 193 LYS A CA  1 
ATOM 1125 C C   . LYS A 1 150 ? 130.029 104.499 124.999 1.00 41.32 ? 193 LYS A C   1 
ATOM 1126 O O   . LYS A 1 150 ? 131.191 104.909 125.090 1.00 51.99 ? 193 LYS A O   1 
ATOM 1127 C CB  . LYS A 1 150 ? 129.642 104.118 122.561 1.00 40.02 ? 193 LYS A CB  1 
ATOM 1128 C CG  . LYS A 1 150 ? 129.439 102.616 122.653 1.00 42.69 ? 193 LYS A CG  1 
ATOM 1129 C CD  . LYS A 1 150 ? 129.627 101.944 121.307 1.00 39.59 ? 193 LYS A CD  1 
ATOM 1130 C CE  . LYS A 1 150 ? 130.878 101.088 121.294 1.00 45.89 ? 193 LYS A CE  1 
ATOM 1131 N NZ  . LYS A 1 150 ? 130.949 100.229 120.082 1.00 48.14 ? 193 LYS A NZ  1 
ATOM 1132 N N   . ILE A 1 151 ? 129.456 103.716 125.910 1.00 41.95 ? 194 ILE A N   1 
ATOM 1133 C CA  . ILE A 1 151 ? 130.194 103.182 127.048 1.00 40.70 ? 194 ILE A CA  1 
ATOM 1134 C C   . ILE A 1 151 ? 130.417 101.691 126.839 1.00 51.80 ? 194 ILE A C   1 
ATOM 1135 O O   . ILE A 1 151 ? 129.561 100.870 127.187 1.00 56.80 ? 194 ILE A O   1 
ATOM 1136 C CB  . ILE A 1 151 ? 129.458 103.448 128.374 1.00 46.48 ? 194 ILE A CB  1 
ATOM 1137 C CG1 . ILE A 1 151 ? 128.623 104.725 128.283 1.00 50.85 ? 194 ILE A CG1 1 
ATOM 1138 C CG2 . ILE A 1 151 ? 130.447 103.528 129.525 1.00 52.45 ? 194 ILE A CG2 1 
ATOM 1139 C CD1 . ILE A 1 151 ? 127.839 105.028 129.539 1.00 47.56 ? 194 ILE A CD1 1 
ATOM 1140 N N   . ASP A 1 152 ? 131.564 101.334 126.269 1.00 63.97 ? 195 ASP A N   1 
ATOM 1141 C CA  . ASP A 1 152 ? 131.891 99.930  126.065 1.00 58.14 ? 195 ASP A CA  1 
ATOM 1142 C C   . ASP A 1 152 ? 132.142 99.246  127.402 1.00 55.06 ? 195 ASP A C   1 
ATOM 1143 O O   . ASP A 1 152 ? 132.815 99.792  128.280 1.00 60.55 ? 195 ASP A O   1 
ATOM 1144 C CB  . ASP A 1 152 ? 133.119 99.797  125.166 1.00 60.27 ? 195 ASP A CB  1 
ATOM 1145 C CG  . ASP A 1 152 ? 133.094 98.533  124.330 1.00 68.26 ? 195 ASP A CG  1 
ATOM 1146 O OD1 . ASP A 1 152 ? 132.157 97.725  124.498 1.00 68.37 ? 195 ASP A OD1 1 
ATOM 1147 O OD2 . ASP A 1 152 ? 134.013 98.347  123.505 1.00 68.79 ? 195 ASP A OD2 1 
ATOM 1148 N N   . LEU A 1 153 ? 131.587 98.048  127.560 1.00 44.49 ? 196 LEU A N   1 
ATOM 1149 C CA  . LEU A 1 153 ? 131.732 97.284  128.790 1.00 45.84 ? 196 LEU A CA  1 
ATOM 1150 C C   . LEU A 1 153 ? 132.817 96.220  128.707 1.00 47.10 ? 196 LEU A C   1 
ATOM 1151 O O   . LEU A 1 153 ? 133.031 95.496  129.682 1.00 50.81 ? 196 LEU A O   1 
ATOM 1152 C CB  . LEU A 1 153 ? 130.399 96.636  129.169 1.00 44.56 ? 196 LEU A CB  1 
ATOM 1153 C CG  . LEU A 1 153 ? 129.301 97.606  129.605 1.00 51.12 ? 196 LEU A CG  1 
ATOM 1154 C CD1 . LEU A 1 153 ? 128.108 96.846  130.142 1.00 49.97 ? 196 LEU A CD1 1 
ATOM 1155 C CD2 . LEU A 1 153 ? 129.827 98.584  130.641 1.00 51.38 ? 196 LEU A CD2 1 
ATOM 1156 N N   . THR A 1 154 ? 133.499 96.106  127.572 1.00 51.60 ? 197 THR A N   1 
ATOM 1157 C CA  . THR A 1 154 ? 134.635 95.208  127.427 1.00 53.59 ? 197 THR A CA  1 
ATOM 1158 C C   . THR A 1 154 ? 135.964 95.954  127.475 1.00 57.65 ? 197 THR A C   1 
ATOM 1159 O O   . THR A 1 154 ? 137.023 95.322  127.409 1.00 57.00 ? 197 THR A O   1 
ATOM 1160 C CB  . THR A 1 154 ? 134.516 94.422  126.116 1.00 56.17 ? 197 THR A CB  1 
ATOM 1161 O OG1 . THR A 1 154 ? 133.141 94.095  125.883 1.00 58.51 ? 197 THR A OG1 1 
ATOM 1162 C CG2 . THR A 1 154 ? 135.310 93.123  126.187 1.00 54.91 ? 197 THR A CG2 1 
ATOM 1163 N N   . ASP A 1 155 ? 135.931 97.277  127.609 1.00 59.49 ? 198 ASP A N   1 
ATOM 1164 C CA  . ASP A 1 155 ? 137.146 98.074  127.602 1.00 59.23 ? 198 ASP A CA  1 
ATOM 1165 C C   . ASP A 1 155 ? 137.951 97.859  128.880 1.00 56.89 ? 198 ASP A C   1 
ATOM 1166 O O   . ASP A 1 155 ? 137.435 97.420  129.912 1.00 59.18 ? 198 ASP A O   1 
ATOM 1167 C CB  . ASP A 1 155 ? 136.812 99.560  127.436 1.00 63.01 ? 198 ASP A CB  1 
ATOM 1168 C CG  . ASP A 1 155 ? 135.799 100.062 128.461 1.00 57.14 ? 198 ASP A CG  1 
ATOM 1169 O OD1 . ASP A 1 155 ? 135.488 99.332  129.425 1.00 55.08 ? 198 ASP A OD1 1 
ATOM 1170 O OD2 . ASP A 1 155 ? 135.309 101.198 128.300 1.00 48.43 ? 198 ASP A OD2 1 
ATOM 1171 N N   . SER A 1 156 ? 139.246 98.167  128.794 1.00 56.86 ? 199 SER A N   1 
ATOM 1172 C CA  . SER A 1 156 ? 140.087 98.164  129.985 1.00 61.82 ? 199 SER A CA  1 
ATOM 1173 C C   . SER A 1 156 ? 139.853 99.408  130.833 1.00 61.41 ? 199 SER A C   1 
ATOM 1174 O O   . SER A 1 156 ? 139.881 99.337  132.066 1.00 60.83 ? 199 SER A O   1 
ATOM 1175 C CB  . SER A 1 156 ? 141.559 98.058  129.587 1.00 63.59 ? 199 SER A CB  1 
ATOM 1176 O OG  . SER A 1 156 ? 142.078 99.324  129.220 1.00 65.19 ? 199 SER A OG  1 
ATOM 1177 N N   . GLY A 1 157 ? 139.617 100.551 130.191 1.00 60.69 ? 200 GLY A N   1 
ATOM 1178 C CA  . GLY A 1 157 ? 139.431 101.806 130.885 1.00 61.71 ? 200 GLY A CA  1 
ATOM 1179 C C   . GLY A 1 157 ? 137.999 102.021 131.334 1.00 60.92 ? 200 GLY A C   1 
ATOM 1180 O O   . GLY A 1 157 ? 137.147 101.133 131.265 1.00 64.81 ? 200 GLY A O   1 
ATOM 1181 N N   . LYS A 1 158 ? 137.738 103.238 131.805 1.00 47.98 ? 201 LYS A N   1 
ATOM 1182 C CA  . LYS A 1 158 ? 136.430 103.619 132.313 1.00 44.96 ? 201 LYS A CA  1 
ATOM 1183 C C   . LYS A 1 158 ? 136.015 104.956 131.716 1.00 48.10 ? 201 LYS A C   1 
ATOM 1184 O O   . LYS A 1 158 ? 136.856 105.801 131.399 1.00 47.98 ? 201 LYS A O   1 
ATOM 1185 C CB  . LYS A 1 158 ? 136.425 103.705 133.841 1.00 43.45 ? 201 LYS A CB  1 
ATOM 1186 C CG  . LYS A 1 158 ? 135.979 102.427 134.524 1.00 47.88 ? 201 LYS A CG  1 
ATOM 1187 C CD  . LYS A 1 158 ? 137.003 101.958 135.540 1.00 54.04 ? 201 LYS A CD  1 
ATOM 1188 C CE  . LYS A 1 158 ? 136.569 100.657 136.194 1.00 53.88 ? 201 LYS A CE  1 
ATOM 1189 N NZ  . LYS A 1 158 ? 136.000 99.705  135.201 1.00 54.08 ? 201 LYS A NZ  1 
ATOM 1190 N N   . PHE A 1 159 ? 134.706 105.136 131.567 1.00 55.63 ? 202 PHE A N   1 
ATOM 1191 C CA  . PHE A 1 159 ? 134.128 106.326 130.957 1.00 48.21 ? 202 PHE A CA  1 
ATOM 1192 C C   . PHE A 1 159 ? 133.424 107.142 132.031 1.00 51.45 ? 202 PHE A C   1 
ATOM 1193 O O   . PHE A 1 159 ? 132.500 106.647 132.686 1.00 50.91 ? 202 PHE A O   1 
ATOM 1194 C CB  . PHE A 1 159 ? 133.155 105.942 129.841 1.00 47.97 ? 202 PHE A CB  1 
ATOM 1195 C CG  . PHE A 1 159 ? 132.380 107.100 129.276 1.00 48.95 ? 202 PHE A CG  1 
ATOM 1196 C CD1 . PHE A 1 159 ? 132.902 107.862 128.247 1.00 49.15 ? 202 PHE A CD1 1 
ATOM 1197 C CD2 . PHE A 1 159 ? 131.121 107.412 129.759 1.00 51.74 ? 202 PHE A CD2 1 
ATOM 1198 C CE1 . PHE A 1 159 ? 132.190 108.920 127.722 1.00 50.45 ? 202 PHE A CE1 1 
ATOM 1199 C CE2 . PHE A 1 159 ? 130.406 108.469 129.238 1.00 53.00 ? 202 PHE A CE2 1 
ATOM 1200 C CZ  . PHE A 1 159 ? 130.940 109.224 128.219 1.00 51.30 ? 202 PHE A CZ  1 
ATOM 1201 N N   . SER A 1 160 ? 133.856 108.388 132.205 1.00 58.56 ? 203 SER A N   1 
ATOM 1202 C CA  . SER A 1 160 ? 133.244 109.317 133.142 1.00 54.31 ? 203 SER A CA  1 
ATOM 1203 C C   . SER A 1 160 ? 133.036 110.655 132.452 1.00 56.88 ? 203 SER A C   1 
ATOM 1204 O O   . SER A 1 160 ? 133.870 111.083 131.649 1.00 56.32 ? 203 SER A O   1 
ATOM 1205 C CB  . SER A 1 160 ? 134.106 109.498 134.396 1.00 55.01 ? 203 SER A CB  1 
ATOM 1206 O OG  . SER A 1 160 ? 133.501 110.403 135.303 1.00 61.68 ? 203 SER A OG  1 
ATOM 1207 N N   . ARG A 1 161 ? 131.922 111.312 132.765 1.00 50.33 ? 204 ARG A N   1 
ATOM 1208 C CA  . ARG A 1 161 ? 131.586 112.586 132.138 1.00 49.72 ? 204 ARG A CA  1 
ATOM 1209 C C   . ARG A 1 161 ? 130.686 113.371 133.078 1.00 50.62 ? 204 ARG A C   1 
ATOM 1210 O O   . ARG A 1 161 ? 129.625 112.881 133.472 1.00 55.48 ? 204 ARG A O   1 
ATOM 1211 C CB  . ARG A 1 161 ? 130.902 112.366 130.788 1.00 55.69 ? 204 ARG A CB  1 
ATOM 1212 C CG  . ARG A 1 161 ? 130.126 113.562 130.276 1.00 50.76 ? 204 ARG A CG  1 
ATOM 1213 C CD  . ARG A 1 161 ? 131.048 114.666 129.801 1.00 41.71 ? 204 ARG A CD  1 
ATOM 1214 N NE  . ARG A 1 161 ? 130.302 115.764 129.201 1.00 44.89 ? 204 ARG A NE  1 
ATOM 1215 C CZ  . ARG A 1 161 ? 130.830 116.683 128.407 1.00 45.46 ? 204 ARG A CZ  1 
ATOM 1216 N NH1 . ARG A 1 161 ? 132.115 116.670 128.094 1.00 52.69 ? 204 ARG A NH1 1 
ATOM 1217 N NH2 . ARG A 1 161 ? 130.050 117.640 127.914 1.00 50.33 ? 204 ARG A NH2 1 
ATOM 1218 N N   . GLU A 1 162 ? 131.110 114.581 133.431 1.00 57.87 ? 205 GLU A N   1 
ATOM 1219 C CA  . GLU A 1 162 ? 130.384 115.452 134.351 1.00 59.27 ? 205 GLU A CA  1 
ATOM 1220 C C   . GLU A 1 162 ? 129.764 116.587 133.543 1.00 62.88 ? 205 GLU A C   1 
ATOM 1221 O O   . GLU A 1 162 ? 130.461 117.518 133.131 1.00 66.04 ? 205 GLU A O   1 
ATOM 1222 C CB  . GLU A 1 162 ? 131.316 115.988 135.434 1.00 56.75 ? 205 GLU A CB  1 
ATOM 1223 C CG  . GLU A 1 162 ? 130.620 116.772 136.530 1.00 58.27 ? 205 GLU A CG  1 
ATOM 1224 C CD  . GLU A 1 162 ? 130.465 115.974 137.808 1.00 61.87 ? 205 GLU A CD  1 
ATOM 1225 O OE1 . GLU A 1 162 ? 131.249 115.024 138.015 1.00 60.69 ? 205 GLU A OE1 1 
ATOM 1226 O OE2 . GLU A 1 162 ? 129.561 116.297 138.607 1.00 62.44 ? 205 GLU A OE2 1 
ATOM 1227 N N   . ASN A 1 163 ? 128.452 116.515 133.327 1.00 57.68 ? 206 ASN A N   1 
ATOM 1228 C CA  . ASN A 1 163 ? 127.733 117.529 132.557 1.00 57.35 ? 206 ASN A CA  1 
ATOM 1229 C C   . ASN A 1 163 ? 127.338 118.654 133.506 1.00 61.02 ? 206 ASN A C   1 
ATOM 1230 O O   . ASN A 1 163 ? 126.410 118.512 134.306 1.00 59.37 ? 206 ASN A O   1 
ATOM 1231 C CB  . ASN A 1 163 ? 126.514 116.926 131.869 1.00 59.77 ? 206 ASN A CB  1 
ATOM 1232 C CG  . ASN A 1 163 ? 126.847 115.681 131.076 1.00 64.36 ? 206 ASN A CG  1 
ATOM 1233 O OD1 . ASN A 1 163 ? 127.745 115.688 130.236 1.00 67.59 ? 206 ASN A OD1 1 
ATOM 1234 N ND2 . ASN A 1 163 ? 126.122 114.601 131.339 1.00 59.08 ? 206 ASN A ND2 1 
ATOM 1235 N N   . LYS A 1 164 ? 128.041 119.777 133.413 1.00 57.58 ? 207 LYS A N   1 
ATOM 1236 C CA  . LYS A 1 164 ? 127.834 120.895 134.319 1.00 48.48 ? 207 LYS A CA  1 
ATOM 1237 C C   . LYS A 1 164 ? 126.846 121.899 133.739 1.00 53.47 ? 207 LYS A C   1 
ATOM 1238 O O   . LYS A 1 164 ? 126.673 122.004 132.522 1.00 55.48 ? 207 LYS A O   1 
ATOM 1239 C CB  . LYS A 1 164 ? 129.156 121.601 134.618 1.00 47.34 ? 207 LYS A CB  1 
ATOM 1240 C CG  . LYS A 1 164 ? 130.244 120.699 135.156 1.00 46.77 ? 207 LYS A CG  1 
ATOM 1241 C CD  . LYS A 1 164 ? 131.559 121.449 135.261 1.00 47.21 ? 207 LYS A CD  1 
ATOM 1242 C CE  . LYS A 1 164 ? 132.681 120.539 135.723 1.00 53.37 ? 207 LYS A CE  1 
ATOM 1243 N NZ  . LYS A 1 164 ? 133.970 121.273 135.845 1.00 56.45 ? 207 LYS A NZ  1 
ATOM 1244 N N   . GLN A 1 165 ? 126.195 122.639 134.634 1.00 52.04 ? 208 GLN A N   1 
ATOM 1245 C CA  . GLN A 1 165 ? 125.343 123.772 134.279 1.00 50.19 ? 208 GLN A CA  1 
ATOM 1246 C C   . GLN A 1 165 ? 125.727 124.919 135.208 1.00 51.98 ? 208 GLN A C   1 
ATOM 1247 O O   . GLN A 1 165 ? 125.250 124.989 136.344 1.00 56.78 ? 208 GLN A O   1 
ATOM 1248 C CB  . GLN A 1 165 ? 123.862 123.424 134.404 1.00 47.92 ? 208 GLN A CB  1 
ATOM 1249 C CG  . GLN A 1 165 ? 123.432 122.190 133.631 1.00 47.18 ? 208 GLN A CG  1 
ATOM 1250 C CD  . GLN A 1 165 ? 123.253 122.463 132.152 1.00 53.93 ? 208 GLN A CD  1 
ATOM 1251 O OE1 . GLN A 1 165 ? 123.117 123.611 131.733 1.00 53.58 ? 208 GLN A OE1 1 
ATOM 1252 N NE2 . GLN A 1 165 ? 123.251 121.404 131.351 1.00 53.66 ? 208 GLN A NE2 1 
ATOM 1253 N N   . ASP A 1 166 ? 126.587 125.813 134.735 1.00 53.23 ? 209 ASP A N   1 
ATOM 1254 C CA  . ASP A 1 166 ? 127.103 126.890 135.571 1.00 51.60 ? 209 ASP A CA  1 
ATOM 1255 C C   . ASP A 1 166 ? 127.354 128.109 134.688 1.00 54.66 ? 209 ASP A C   1 
ATOM 1256 O O   . ASP A 1 166 ? 126.841 128.197 133.568 1.00 57.26 ? 209 ASP A O   1 
ATOM 1257 C CB  . ASP A 1 166 ? 128.354 126.421 136.336 1.00 50.35 ? 209 ASP A CB  1 
ATOM 1258 C CG  . ASP A 1 166 ? 129.403 125.801 135.430 1.00 60.34 ? 209 ASP A CG  1 
ATOM 1259 O OD1 . ASP A 1 166 ? 129.372 126.049 134.206 1.00 61.55 ? 209 ASP A OD1 1 
ATOM 1260 O OD2 . ASP A 1 166 ? 130.265 125.060 135.947 1.00 62.00 ? 209 ASP A OD2 1 
ATOM 1261 N N   . ASP A 1 167 ? 128.140 129.060 135.198 1.00 50.64 ? 210 ASP A N   1 
ATOM 1262 C CA  . ASP A 1 167 ? 128.386 130.303 134.479 1.00 49.06 ? 210 ASP A CA  1 
ATOM 1263 C C   . ASP A 1 167 ? 129.135 130.089 133.170 1.00 56.98 ? 210 ASP A C   1 
ATOM 1264 O O   . ASP A 1 167 ? 129.139 130.988 132.323 1.00 62.33 ? 210 ASP A O   1 
ATOM 1265 C CB  . ASP A 1 167 ? 129.164 131.275 135.365 1.00 51.56 ? 210 ASP A CB  1 
ATOM 1266 C CG  . ASP A 1 167 ? 130.229 130.585 136.191 1.00 57.78 ? 210 ASP A CG  1 
ATOM 1267 O OD1 . ASP A 1 167 ? 130.397 129.357 136.041 1.00 58.64 ? 210 ASP A OD1 1 
ATOM 1268 O OD2 . ASP A 1 167 ? 130.900 131.270 136.991 1.00 60.63 ? 210 ASP A OD2 1 
ATOM 1269 N N   . THR A 1 168 ? 129.775 128.933 132.988 1.00 51.03 ? 211 THR A N   1 
ATOM 1270 C CA  . THR A 1 168 ? 130.466 128.612 131.744 1.00 42.88 ? 211 THR A CA  1 
ATOM 1271 C C   . THR A 1 168 ? 129.834 127.421 131.033 1.00 39.69 ? 211 THR A C   1 
ATOM 1272 O O   . THR A 1 168 ? 130.498 126.760 130.229 1.00 49.64 ? 211 THR A O   1 
ATOM 1273 C CB  . THR A 1 168 ? 131.949 128.341 132.003 1.00 47.43 ? 211 THR A CB  1 
ATOM 1274 O OG1 . THR A 1 168 ? 132.100 127.062 132.630 1.00 55.11 ? 211 THR A OG1 1 
ATOM 1275 C CG2 . THR A 1 168 ? 132.538 129.413 132.905 1.00 46.53 ? 211 THR A CG2 1 
ATOM 1276 N N   . ALA A 1 169 ? 128.564 127.133 131.311 1.00 36.36 ? 212 ALA A N   1 
ATOM 1277 C CA  . ALA A 1 169 ? 127.898 125.980 130.711 1.00 42.30 ? 212 ALA A CA  1 
ATOM 1278 C C   . ALA A 1 169 ? 126.396 126.225 130.740 1.00 44.09 ? 212 ALA A C   1 
ATOM 1279 O O   . ALA A 1 169 ? 125.799 126.269 131.819 1.00 44.14 ? 212 ALA A O   1 
ATOM 1280 C CB  . ALA A 1 169 ? 128.260 124.699 131.452 1.00 50.12 ? 212 ALA A CB  1 
ATOM 1281 N N   . ALA A 1 170 ? 125.792 126.379 129.563 1.00 51.17 ? 213 ALA A N   1 
ATOM 1282 C CA  . ALA A 1 170 ? 124.350 126.562 129.434 1.00 51.34 ? 213 ALA A CA  1 
ATOM 1283 C C   . ALA A 1 170 ? 123.836 125.617 128.356 1.00 51.62 ? 213 ALA A C   1 
ATOM 1284 O O   . ALA A 1 170 ? 124.079 125.838 127.166 1.00 56.88 ? 213 ALA A O   1 
ATOM 1285 C CB  . ALA A 1 170 ? 124.003 128.012 129.100 1.00 53.19 ? 213 ALA A CB  1 
ATOM 1286 N N   . SER A 1 171 ? 123.132 124.570 128.773 1.00 47.70 ? 214 SER A N   1 
ATOM 1287 C CA  . SER A 1 171 ? 122.535 123.603 127.860 1.00 48.04 ? 214 SER A CA  1 
ATOM 1288 C C   . SER A 1 171 ? 121.359 122.948 128.576 1.00 47.26 ? 214 SER A C   1 
ATOM 1289 O O   . SER A 1 171 ? 120.933 123.402 129.643 1.00 52.05 ? 214 SER A O   1 
ATOM 1290 C CB  . SER A 1 171 ? 123.574 122.580 127.391 1.00 52.02 ? 214 SER A CB  1 
ATOM 1291 O OG  . SER A 1 171 ? 124.430 123.137 126.409 1.00 57.50 ? 214 SER A OG  1 
ATOM 1292 N N   . ILE A 1 172 ? 120.830 121.879 127.991 1.00 41.24 ? 215 ILE A N   1 
ATOM 1293 C CA  . ILE A 1 172 ? 119.733 121.140 128.613 1.00 45.18 ? 215 ILE A CA  1 
ATOM 1294 C C   . ILE A 1 172 ? 120.282 120.348 129.792 1.00 41.29 ? 215 ILE A C   1 
ATOM 1295 O O   . ILE A 1 172 ? 121.220 119.556 129.625 1.00 45.70 ? 215 ILE A O   1 
ATOM 1296 C CB  . ILE A 1 172 ? 119.009 120.213 127.619 1.00 52.11 ? 215 ILE A CB  1 
ATOM 1297 C CG1 . ILE A 1 172 ? 118.802 120.876 126.250 1.00 50.07 ? 215 ILE A CG1 1 
ATOM 1298 C CG2 . ILE A 1 172 ? 117.676 119.757 128.194 1.00 53.74 ? 215 ILE A CG2 1 
ATOM 1299 C CD1 . ILE A 1 172 ? 119.941 120.710 125.276 1.00 49.93 ? 215 ILE A CD1 1 
ATOM 1300 N N   . PRO A 1 173 ? 119.738 120.528 130.995 1.00 40.53 ? 216 PRO A N   1 
ATOM 1301 C CA  . PRO A 1 173 ? 120.202 119.765 132.167 1.00 46.11 ? 216 PRO A CA  1 
ATOM 1302 C C   . PRO A 1 173 ? 119.562 118.383 132.252 1.00 50.51 ? 216 PRO A C   1 
ATOM 1303 O O   . PRO A 1 173 ? 118.823 118.063 133.186 1.00 54.42 ? 216 PRO A O   1 
ATOM 1304 C CB  . PRO A 1 173 ? 119.789 120.677 133.328 1.00 44.24 ? 216 PRO A CB  1 
ATOM 1305 C CG  . PRO A 1 173 ? 118.556 121.344 132.839 1.00 43.60 ? 216 PRO A CG  1 
ATOM 1306 C CD  . PRO A 1 173 ? 118.733 121.541 131.357 1.00 43.72 ? 216 PRO A CD  1 
ATOM 1307 N N   . VAL A 1 174 ? 119.846 117.545 131.257 1.00 50.54 ? 217 VAL A N   1 
ATOM 1308 C CA  . VAL A 1 174 ? 119.286 116.200 131.184 1.00 50.78 ? 217 VAL A CA  1 
ATOM 1309 C C   . VAL A 1 174 ? 120.368 115.240 130.713 1.00 58.57 ? 217 VAL A C   1 
ATOM 1310 O O   . VAL A 1 174 ? 121.094 115.533 129.758 1.00 62.71 ? 217 VAL A O   1 
ATOM 1311 C CB  . VAL A 1 174 ? 118.062 116.145 130.249 1.00 49.50 ? 217 VAL A CB  1 
ATOM 1312 C CG1 . VAL A 1 174 ? 117.893 114.758 129.659 1.00 51.47 ? 217 VAL A CG1 1 
ATOM 1313 C CG2 . VAL A 1 174 ? 116.815 116.540 131.006 1.00 50.49 ? 217 VAL A CG2 1 
ATOM 1314 N N   . SER A 1 175 ? 120.474 114.094 131.383 1.00 59.22 ? 218 SER A N   1 
ATOM 1315 C CA  . SER A 1 175 ? 121.354 113.013 130.970 1.00 52.91 ? 218 SER A CA  1 
ATOM 1316 C C   . SER A 1 175 ? 120.564 111.713 130.950 1.00 56.39 ? 218 SER A C   1 
ATOM 1317 O O   . SER A 1 175 ? 119.634 111.522 131.738 1.00 56.79 ? 218 SER A O   1 
ATOM 1318 C CB  . SER A 1 175 ? 122.565 112.882 131.899 1.00 57.54 ? 218 SER A CB  1 
ATOM 1319 O OG  . SER A 1 175 ? 123.417 114.006 131.780 1.00 59.22 ? 218 SER A OG  1 
ATOM 1320 N N   . ASP A 1 176 ? 120.940 110.818 130.040 1.00 61.39 ? 219 ASP A N   1 
ATOM 1321 C CA  . ASP A 1 176 ? 120.200 109.581 129.833 1.00 57.33 ? 219 ASP A CA  1 
ATOM 1322 C C   . ASP A 1 176 ? 121.165 108.466 129.461 1.00 55.13 ? 219 ASP A C   1 
ATOM 1323 O O   . ASP A 1 176 ? 122.099 108.681 128.687 1.00 50.60 ? 219 ASP A O   1 
ATOM 1324 C CB  . ASP A 1 176 ? 119.142 109.752 128.735 1.00 56.25 ? 219 ASP A CB  1 
ATOM 1325 C CG  . ASP A 1 176 ? 118.553 108.430 128.276 1.00 61.69 ? 219 ASP A CG  1 
ATOM 1326 O OD1 . ASP A 1 176 ? 118.338 107.539 129.124 1.00 59.92 ? 219 ASP A OD1 1 
ATOM 1327 O OD2 . ASP A 1 176 ? 118.307 108.281 127.061 1.00 62.10 ? 219 ASP A OD2 1 
ATOM 1328 N N   . ILE A 1 177 ? 120.932 107.281 130.022 1.00 52.90 ? 220 ILE A N   1 
ATOM 1329 C CA  . ILE A 1 177 ? 121.655 106.067 129.663 1.00 43.92 ? 220 ILE A CA  1 
ATOM 1330 C C   . ILE A 1 177 ? 120.631 104.994 129.326 1.00 51.83 ? 220 ILE A C   1 
ATOM 1331 O O   . ILE A 1 177 ? 119.623 104.848 130.026 1.00 56.20 ? 220 ILE A O   1 
ATOM 1332 C CB  . ILE A 1 177 ? 122.595 105.594 130.791 1.00 36.59 ? 220 ILE A CB  1 
ATOM 1333 C CG1 . ILE A 1 177 ? 121.833 105.450 132.108 1.00 45.22 ? 220 ILE A CG1 1 
ATOM 1334 C CG2 . ILE A 1 177 ? 123.756 106.554 130.951 1.00 47.21 ? 220 ILE A CG2 1 
ATOM 1335 C CD1 . ILE A 1 177 ? 122.404 104.400 133.028 1.00 46.94 ? 220 ILE A CD1 1 
ATOM 1336 N N   . TYR A 1 178 ? 120.876 104.251 128.248 1.00 47.73 ? 221 TYR A N   1 
ATOM 1337 C CA  . TYR A 1 178 ? 119.890 103.280 127.799 1.00 35.20 ? 221 TYR A CA  1 
ATOM 1338 C C   . TYR A 1 178 ? 120.571 102.082 127.155 1.00 33.80 ? 221 TYR A C   1 
ATOM 1339 O O   . TYR A 1 178 ? 121.702 102.162 126.671 1.00 41.34 ? 221 TYR A O   1 
ATOM 1340 C CB  . TYR A 1 178 ? 118.885 103.911 126.825 1.00 39.01 ? 221 TYR A CB  1 
ATOM 1341 C CG  . TYR A 1 178 ? 119.448 104.264 125.466 1.00 33.72 ? 221 TYR A CG  1 
ATOM 1342 C CD1 . TYR A 1 178 ? 120.053 105.490 125.242 1.00 39.92 ? 221 TYR A CD1 1 
ATOM 1343 C CD2 . TYR A 1 178 ? 119.348 103.382 124.400 1.00 33.24 ? 221 TYR A CD2 1 
ATOM 1344 C CE1 . TYR A 1 178 ? 120.558 105.819 124.004 1.00 40.10 ? 221 TYR A CE1 1 
ATOM 1345 C CE2 . TYR A 1 178 ? 119.851 103.702 123.160 1.00 31.84 ? 221 TYR A CE2 1 
ATOM 1346 C CZ  . TYR A 1 178 ? 120.453 104.921 122.967 1.00 32.60 ? 221 TYR A CZ  1 
ATOM 1347 O OH  . TYR A 1 178 ? 120.956 105.246 121.730 1.00 41.05 ? 221 TYR A OH  1 
ATOM 1348 N N   . ILE A 1 179 ? 119.846 100.964 127.159 1.00 43.63 ? 222 ILE A N   1 
ATOM 1349 C CA  . ILE A 1 179 ? 120.234 99.741  126.467 1.00 41.58 ? 222 ILE A CA  1 
ATOM 1350 C C   . ILE A 1 179 ? 119.053 99.304  125.611 1.00 50.56 ? 222 ILE A C   1 
ATOM 1351 O O   . ILE A 1 179 ? 118.061 100.032 125.492 1.00 56.51 ? 222 ILE A O   1 
ATOM 1352 C CB  . ILE A 1 179 ? 120.660 98.633  127.446 1.00 29.56 ? 222 ILE A CB  1 
ATOM 1353 C CG1 . ILE A 1 179 ? 119.586 98.418  128.509 1.00 39.51 ? 222 ILE A CG1 1 
ATOM 1354 C CG2 . ILE A 1 179 ? 121.993 98.973  128.086 1.00 41.62 ? 222 ILE A CG2 1 
ATOM 1355 C CD1 . ILE A 1 179 ? 119.849 97.233  129.401 1.00 45.83 ? 222 ILE A CD1 1 
ATOM 1356 N N   . ALA A 1 180 ? 119.157 98.123  124.996 1.00 49.55 ? 223 ALA A N   1 
ATOM 1357 C CA  . ALA A 1 180 ? 118.094 97.648  124.114 1.00 47.23 ? 223 ALA A CA  1 
ATOM 1358 C C   . ALA A 1 180 ? 116.764 97.529  124.850 1.00 45.17 ? 223 ALA A C   1 
ATOM 1359 O O   . ALA A 1 180 ? 115.711 97.871  124.301 1.00 50.69 ? 223 ALA A O   1 
ATOM 1360 C CB  . ALA A 1 180 ? 118.485 96.306  123.498 1.00 49.23 ? 223 ALA A CB  1 
ATOM 1361 N N   . ASP A 1 181 ? 116.790 97.038  126.090 1.00 47.56 ? 224 ASP A N   1 
ATOM 1362 C CA  . ASP A 1 181 ? 115.555 96.891  126.853 1.00 44.98 ? 224 ASP A CA  1 
ATOM 1363 C C   . ASP A 1 181 ? 114.917 98.242  127.159 1.00 46.98 ? 224 ASP A C   1 
ATOM 1364 O O   . ASP A 1 181 ? 113.693 98.388  127.075 1.00 55.99 ? 224 ASP A O   1 
ATOM 1365 C CB  . ASP A 1 181 ? 115.826 96.124  128.146 1.00 53.01 ? 224 ASP A CB  1 
ATOM 1366 C CG  . ASP A 1 181 ? 115.598 94.634  127.998 1.00 57.22 ? 224 ASP A CG  1 
ATOM 1367 O OD1 . ASP A 1 181 ? 114.509 94.242  127.528 1.00 58.20 ? 224 ASP A OD1 1 
ATOM 1368 O OD2 . ASP A 1 181 ? 116.506 93.854  128.351 1.00 55.58 ? 224 ASP A OD2 1 
ATOM 1369 N N   . GLY A 1 182 ? 115.724 99.236  127.514 1.00 39.37 ? 225 GLY A N   1 
ATOM 1370 C CA  . GLY A 1 182 ? 115.183 100.530 127.888 1.00 42.37 ? 225 GLY A CA  1 
ATOM 1371 C C   . GLY A 1 182 ? 116.279 101.440 128.404 1.00 44.67 ? 225 GLY A C   1 
ATOM 1372 O O   . GLY A 1 182 ? 117.457 101.240 128.108 1.00 49.93 ? 225 GLY A O   1 
ATOM 1373 N N   . GLY A 1 183 ? 115.872 102.440 129.184 1.00 42.11 ? 226 GLY A N   1 
ATOM 1374 C CA  . GLY A 1 183 ? 116.828 103.398 129.708 1.00 46.28 ? 226 GLY A CA  1 
ATOM 1375 C C   . GLY A 1 183 ? 116.255 104.219 130.840 1.00 46.08 ? 226 GLY A C   1 
ATOM 1376 O O   . GLY A 1 183 ? 115.065 104.153 131.153 1.00 46.75 ? 226 GLY A O   1 
ATOM 1377 N N   . ILE A 1 184 ? 117.138 105.004 131.457 1.00 40.54 ? 227 ILE A N   1 
ATOM 1378 C CA  . ILE A 1 184 ? 116.797 105.864 132.584 1.00 39.31 ? 227 ILE A CA  1 
ATOM 1379 C C   . ILE A 1 184 ? 117.292 107.270 132.281 1.00 42.33 ? 227 ILE A C   1 
ATOM 1380 O O   . ILE A 1 184 ? 118.448 107.453 131.885 1.00 48.23 ? 227 ILE A O   1 
ATOM 1381 C CB  . ILE A 1 184 ? 117.410 105.353 133.902 1.00 38.67 ? 227 ILE A CB  1 
ATOM 1382 C CG1 . ILE A 1 184 ? 116.845 103.980 134.261 1.00 43.57 ? 227 ILE A CG1 1 
ATOM 1383 C CG2 . ILE A 1 184 ? 117.158 106.340 135.028 1.00 44.52 ? 227 ILE A CG2 1 
ATOM 1384 C CD1 . ILE A 1 184 ? 117.452 103.387 135.506 1.00 47.84 ? 227 ILE A CD1 1 
ATOM 1385 N N   . THR A 1 185 ? 116.423 108.260 132.474 1.00 47.72 ? 228 THR A N   1 
ATOM 1386 C CA  . THR A 1 185 ? 116.750 109.659 132.229 1.00 50.55 ? 228 THR A CA  1 
ATOM 1387 C C   . THR A 1 185 ? 116.505 110.464 133.497 1.00 53.39 ? 228 THR A C   1 
ATOM 1388 O O   . THR A 1 185 ? 115.439 110.352 134.111 1.00 55.77 ? 228 THR A O   1 
ATOM 1389 C CB  . THR A 1 185 ? 115.918 110.227 131.077 1.00 51.41 ? 228 THR A CB  1 
ATOM 1390 O OG1 . THR A 1 185 ? 116.133 109.443 129.897 1.00 51.82 ? 228 THR A OG1 1 
ATOM 1391 C CG2 . THR A 1 185 ? 116.309 111.666 130.798 1.00 52.05 ? 228 THR A CG2 1 
ATOM 1392 N N   . VAL A 1 186 ? 117.490 111.271 133.884 1.00 54.92 ? 229 VAL A N   1 
ATOM 1393 C CA  . VAL A 1 186 ? 117.404 112.130 135.059 1.00 49.73 ? 229 VAL A CA  1 
ATOM 1394 C C   . VAL A 1 186 ? 117.653 113.566 134.621 1.00 56.58 ? 229 VAL A C   1 
ATOM 1395 O O   . VAL A 1 186 ? 118.629 113.844 133.916 1.00 56.89 ? 229 VAL A O   1 
ATOM 1396 C CB  . VAL A 1 186 ? 118.405 111.706 136.150 1.00 51.20 ? 229 VAL A CB  1 
ATOM 1397 C CG1 . VAL A 1 186 ? 118.392 112.700 137.298 1.00 53.88 ? 229 VAL A CG1 1 
ATOM 1398 C CG2 . VAL A 1 186 ? 118.078 110.312 136.652 1.00 54.98 ? 229 VAL A CG2 1 
ATOM 1399 N N   . GLY A 1 187 ? 116.771 114.472 135.037 1.00 56.97 ? 230 GLY A N   1 
ATOM 1400 C CA  . GLY A 1 187 ? 116.889 115.867 134.653 1.00 50.02 ? 230 GLY A CA  1 
ATOM 1401 C C   . GLY A 1 187 ? 116.355 116.787 135.728 1.00 50.78 ? 230 GLY A C   1 
ATOM 1402 O O   . GLY A 1 187 ? 115.617 116.372 136.627 1.00 54.93 ? 230 GLY A O   1 
ATOM 1403 N N   . ASP A 1 188 ? 116.736 118.057 135.616 1.00 51.36 ? 231 ASP A N   1 
ATOM 1404 C CA  . ASP A 1 188 ? 116.351 119.062 136.593 1.00 45.27 ? 231 ASP A CA  1 
ATOM 1405 C C   . ASP A 1 188 ? 114.864 119.390 136.488 1.00 43.23 ? 231 ASP A C   1 
ATOM 1406 O O   . ASP A 1 188 ? 114.229 119.208 135.446 1.00 57.67 ? 231 ASP A O   1 
ATOM 1407 C CB  . ASP A 1 188 ? 117.175 120.335 136.403 1.00 43.66 ? 231 ASP A CB  1 
ATOM 1408 C CG  . ASP A 1 188 ? 117.406 121.078 137.700 1.00 44.81 ? 231 ASP A CG  1 
ATOM 1409 O OD1 . ASP A 1 188 ? 117.232 120.470 138.775 1.00 51.86 ? 231 ASP A OD1 1 
ATOM 1410 O OD2 . ASP A 1 188 ? 117.757 122.273 137.644 1.00 50.12 ? 231 ASP A OD2 1 
ATOM 1411 N N   . ALA A 1 189 ? 114.311 119.882 137.596 1.00 33.13 ? 232 ALA A N   1 
ATOM 1412 C CA  . ALA A 1 189 ? 112.919 120.324 137.673 1.00 38.77 ? 232 ALA A CA  1 
ATOM 1413 C C   . ALA A 1 189 ? 112.921 121.745 138.227 1.00 40.40 ? 232 ALA A C   1 
ATOM 1414 O O   . ALA A 1 189 ? 112.808 121.948 139.438 1.00 41.46 ? 232 ALA A O   1 
ATOM 1415 C CB  . ALA A 1 189 ? 112.085 119.381 138.532 1.00 45.71 ? 232 ALA A CB  1 
ATOM 1416 N N   . SER A 1 190 ? 113.047 122.726 137.336 1.00 43.71 ? 233 SER A N   1 
ATOM 1417 C CA  . SER A 1 190 ? 113.103 124.124 137.742 1.00 45.29 ? 233 SER A CA  1 
ATOM 1418 C C   . SER A 1 190 ? 112.686 124.995 136.568 1.00 47.61 ? 233 SER A C   1 
ATOM 1419 O O   . SER A 1 190 ? 113.216 124.841 135.464 1.00 54.73 ? 233 SER A O   1 
ATOM 1420 C CB  . SER A 1 190 ? 114.509 124.504 138.218 1.00 46.52 ? 233 SER A CB  1 
ATOM 1421 O OG  . SER A 1 190 ? 114.703 125.906 138.172 1.00 51.78 ? 233 SER A OG  1 
ATOM 1422 N N   . ALA A 1 191 ? 111.743 125.907 136.810 1.00 43.45 ? 234 ALA A N   1 
ATOM 1423 C CA  . ALA A 1 191 ? 111.275 126.807 135.764 1.00 43.08 ? 234 ALA A CA  1 
ATOM 1424 C C   . ALA A 1 191 ? 112.306 127.858 135.381 1.00 42.05 ? 234 ALA A C   1 
ATOM 1425 O O   . ALA A 1 191 ? 112.144 128.507 134.343 1.00 48.73 ? 234 ALA A O   1 
ATOM 1426 C CB  . ALA A 1 191 ? 109.981 127.492 136.202 1.00 45.54 ? 234 ALA A CB  1 
ATOM 1427 N N   . THR A 1 192 ? 113.350 128.043 136.183 1.00 35.84 ? 235 THR A N   1 
ATOM 1428 C CA  . THR A 1 192 ? 114.401 129.006 135.900 1.00 34.55 ? 235 THR A CA  1 
ATOM 1429 C C   . THR A 1 192 ? 115.754 128.320 136.015 1.00 38.26 ? 235 THR A C   1 
ATOM 1430 O O   . THR A 1 192 ? 115.899 127.296 136.688 1.00 47.43 ? 235 THR A O   1 
ATOM 1431 C CB  . THR A 1 192 ? 114.335 130.211 136.848 1.00 48.55 ? 235 THR A CB  1 
ATOM 1432 O OG1 . THR A 1 192 ? 113.932 129.775 138.152 1.00 49.34 ? 235 THR A OG1 1 
ATOM 1433 C CG2 . THR A 1 192 ? 113.340 131.239 136.333 1.00 47.03 ? 235 THR A CG2 1 
ATOM 1434 N N   . ARG A 1 193 ? 116.747 128.895 135.343 1.00 41.70 ? 236 ARG A N   1 
ATOM 1435 C CA  . ARG A 1 193 ? 118.079 128.306 135.328 1.00 39.59 ? 236 ARG A CA  1 
ATOM 1436 C C   . ARG A 1 193 ? 118.721 128.366 136.709 1.00 50.33 ? 236 ARG A C   1 
ATOM 1437 O O   . ARG A 1 193 ? 118.513 129.315 137.469 1.00 53.06 ? 236 ARG A O   1 
ATOM 1438 C CB  . ARG A 1 193 ? 118.965 129.022 134.310 1.00 32.17 ? 236 ARG A CB  1 
ATOM 1439 C CG  . ARG A 1 193 ? 120.306 128.350 134.087 1.00 37.44 ? 236 ARG A CG  1 
ATOM 1440 C CD  . ARG A 1 193 ? 120.903 128.726 132.747 1.00 48.41 ? 236 ARG A CD  1 
ATOM 1441 N NE  . ARG A 1 193 ? 120.441 127.850 131.677 1.00 43.80 ? 236 ARG A NE  1 
ATOM 1442 C CZ  . ARG A 1 193 ? 120.941 126.650 131.422 1.00 36.73 ? 236 ARG A CZ  1 
ATOM 1443 N NH1 . ARG A 1 193 ? 121.920 126.140 132.151 1.00 43.91 ? 236 ARG A NH1 1 
ATOM 1444 N NH2 . ARG A 1 193 ? 120.448 125.943 130.410 1.00 40.81 ? 236 ARG A NH2 1 
ATOM 1445 N N   . ARG A 1 194 ? 119.492 127.332 137.035 1.00 43.44 ? 237 ARG A N   1 
ATOM 1446 C CA  . ARG A 1 194 ? 120.294 127.303 138.251 1.00 39.85 ? 237 ARG A CA  1 
ATOM 1447 C C   . ARG A 1 194 ? 121.521 126.435 137.989 1.00 49.15 ? 237 ARG A C   1 
ATOM 1448 O O   . ARG A 1 194 ? 121.839 126.113 136.840 1.00 54.86 ? 237 ARG A O   1 
ATOM 1449 C CB  . ARG A 1 194 ? 119.465 126.809 139.443 1.00 35.98 ? 237 ARG A CB  1 
ATOM 1450 C CG  . ARG A 1 194 ? 118.865 125.434 139.273 1.00 35.58 ? 237 ARG A CG  1 
ATOM 1451 C CD  . ARG A 1 194 ? 117.860 125.159 140.376 1.00 42.36 ? 237 ARG A CD  1 
ATOM 1452 N NE  . ARG A 1 194 ? 117.300 123.816 140.295 1.00 47.98 ? 237 ARG A NE  1 
ATOM 1453 C CZ  . ARG A 1 194 ? 116.354 123.352 141.100 1.00 46.73 ? 237 ARG A CZ  1 
ATOM 1454 N NH1 . ARG A 1 194 ? 115.835 124.100 142.059 1.00 46.15 ? 237 ARG A NH1 1 
ATOM 1455 N NH2 . ARG A 1 194 ? 115.917 122.107 140.938 1.00 49.25 ? 237 ARG A NH2 1 
ATOM 1456 N N   . GLU A 1 195 ? 122.217 126.057 139.058 1.00 54.61 ? 238 GLU A N   1 
ATOM 1457 C CA  . GLU A 1 195 ? 123.435 125.263 138.958 1.00 51.49 ? 238 GLU A CA  1 
ATOM 1458 C C   . GLU A 1 195 ? 123.116 123.808 139.278 1.00 57.05 ? 238 GLU A C   1 
ATOM 1459 O O   . GLU A 1 195 ? 122.624 123.502 140.370 1.00 59.61 ? 238 GLU A O   1 
ATOM 1460 C CB  . GLU A 1 195 ? 124.513 125.798 139.897 1.00 48.99 ? 238 GLU A CB  1 
ATOM 1461 C CG  . GLU A 1 195 ? 125.894 125.231 139.632 1.00 55.48 ? 238 GLU A CG  1 
ATOM 1462 C CD  . GLU A 1 195 ? 126.993 126.063 140.257 1.00 60.64 ? 238 GLU A CD  1 
ATOM 1463 O OE1 . GLU A 1 195 ? 126.711 127.206 140.670 1.00 59.61 ? 238 GLU A OE1 1 
ATOM 1464 O OE2 . GLU A 1 195 ? 128.139 125.574 140.334 1.00 60.38 ? 238 GLU A OE2 1 
ATOM 1465 N N   . VAL A 1 196 ? 123.406 122.917 138.332 1.00 48.71 ? 239 VAL A N   1 
ATOM 1466 C CA  . VAL A 1 196 ? 123.060 121.503 138.444 1.00 40.94 ? 239 VAL A CA  1 
ATOM 1467 C C   . VAL A 1 196 ? 124.122 120.686 137.722 1.00 48.24 ? 239 VAL A C   1 
ATOM 1468 O O   . VAL A 1 196 ? 124.590 121.066 136.645 1.00 50.09 ? 239 VAL A O   1 
ATOM 1469 C CB  . VAL A 1 196 ? 121.651 121.228 137.871 1.00 44.69 ? 239 VAL A CB  1 
ATOM 1470 C CG1 . VAL A 1 196 ? 121.518 119.789 137.408 1.00 49.05 ? 239 VAL A CG1 1 
ATOM 1471 C CG2 . VAL A 1 196 ? 120.592 121.542 138.903 1.00 48.08 ? 239 VAL A CG2 1 
ATOM 1472 N N   . HIS A 1 197 ? 124.505 119.561 138.322 1.00 47.20 ? 240 HIS A N   1 
ATOM 1473 C CA  . HIS A 1 197 ? 125.430 118.614 137.716 1.00 43.56 ? 240 HIS A CA  1 
ATOM 1474 C C   . HIS A 1 197 ? 124.694 117.334 137.344 1.00 49.96 ? 240 HIS A C   1 
ATOM 1475 O O   . HIS A 1 197 ? 123.859 116.842 138.110 1.00 53.32 ? 240 HIS A O   1 
ATOM 1476 C CB  . HIS A 1 197 ? 126.587 118.287 138.662 1.00 42.76 ? 240 HIS A CB  1 
ATOM 1477 C CG  . HIS A 1 197 ? 127.696 119.291 138.632 1.00 38.35 ? 240 HIS A CG  1 
ATOM 1478 N ND1 . HIS A 1 197 ? 128.964 119.010 139.092 1.00 43.96 ? 240 HIS A ND1 1 
ATOM 1479 C CD2 . HIS A 1 197 ? 127.727 120.574 138.202 1.00 42.40 ? 240 HIS A CD2 1 
ATOM 1480 C CE1 . HIS A 1 197 ? 129.729 120.076 138.945 1.00 43.92 ? 240 HIS A CE1 1 
ATOM 1481 N NE2 . HIS A 1 197 ? 129.003 121.039 138.407 1.00 41.62 ? 240 HIS A NE2 1 
ATOM 1482 N N   . THR A 1 198 ? 125.007 116.799 136.164 1.00 60.26 ? 241 THR A N   1 
ATOM 1483 C CA  . THR A 1 198 ? 124.428 115.550 135.667 1.00 56.05 ? 241 THR A CA  1 
ATOM 1484 C C   . THR A 1 198 ? 125.560 114.632 135.224 1.00 60.87 ? 241 THR A C   1 
ATOM 1485 O O   . THR A 1 198 ? 125.866 114.535 134.028 1.00 61.31 ? 241 THR A O   1 
ATOM 1486 C CB  . THR A 1 198 ? 123.450 115.803 134.519 1.00 56.56 ? 241 THR A CB  1 
ATOM 1487 O OG1 . THR A 1 198 ? 123.994 116.786 133.631 1.00 61.32 ? 241 THR A OG1 1 
ATOM 1488 C CG2 . THR A 1 198 ? 122.119 116.295 135.042 1.00 53.84 ? 241 THR A CG2 1 
ATOM 1489 N N   . PRO A 1 199 ? 126.205 113.943 136.161 1.00 59.34 ? 242 PRO A N   1 
ATOM 1490 C CA  . PRO A 1 199 ? 127.341 113.093 135.800 1.00 56.32 ? 242 PRO A CA  1 
ATOM 1491 C C   . PRO A 1 199 ? 126.912 111.726 135.290 1.00 59.13 ? 242 PRO A C   1 
ATOM 1492 O O   . PRO A 1 199 ? 125.875 111.182 135.675 1.00 61.58 ? 242 PRO A O   1 
ATOM 1493 C CB  . PRO A 1 199 ? 128.108 112.965 137.121 1.00 57.62 ? 242 PRO A CB  1 
ATOM 1494 C CG  . PRO A 1 199 ? 127.046 113.056 138.160 1.00 56.84 ? 242 PRO A CG  1 
ATOM 1495 C CD  . PRO A 1 199 ? 125.971 113.966 137.615 1.00 54.65 ? 242 PRO A CD  1 
ATOM 1496 N N   . VAL A 1 200 ? 127.740 111.175 134.405 1.00 59.66 ? 243 VAL A N   1 
ATOM 1497 C CA  . VAL A 1 200 ? 127.580 109.820 133.888 1.00 52.07 ? 243 VAL A CA  1 
ATOM 1498 C C   . VAL A 1 200 ? 128.862 109.058 134.192 1.00 54.81 ? 243 VAL A C   1 
ATOM 1499 O O   . VAL A 1 200 ? 129.942 109.441 133.726 1.00 51.18 ? 243 VAL A O   1 
ATOM 1500 C CB  . VAL A 1 200 ? 127.282 109.810 132.381 1.00 54.29 ? 243 VAL A CB  1 
ATOM 1501 C CG1 . VAL A 1 200 ? 126.675 108.481 131.973 1.00 57.44 ? 243 VAL A CG1 1 
ATOM 1502 C CG2 . VAL A 1 200 ? 126.355 110.958 132.011 1.00 58.62 ? 243 VAL A CG2 1 
ATOM 1503 N N   . GLN A 1 201 ? 128.743 107.980 134.964 1.00 65.18 ? 244 GLN A N   1 
ATOM 1504 C CA  . GLN A 1 201 ? 129.893 107.224 135.438 1.00 63.70 ? 244 GLN A CA  1 
ATOM 1505 C C   . GLN A 1 201 ? 129.751 105.761 135.050 1.00 68.57 ? 244 GLN A C   1 
ATOM 1506 O O   . GLN A 1 201 ? 128.661 105.188 135.143 1.00 68.40 ? 244 GLN A O   1 
ATOM 1507 C CB  . GLN A 1 201 ? 130.042 107.349 136.960 1.00 56.67 ? 244 GLN A CB  1 
ATOM 1508 C CG  . GLN A 1 201 ? 131.245 106.627 137.536 1.00 61.88 ? 244 GLN A CG  1 
ATOM 1509 C CD  . GLN A 1 201 ? 132.556 107.273 137.141 1.00 63.79 ? 244 GLN A CD  1 
ATOM 1510 O OE1 . GLN A 1 201 ? 132.739 108.479 137.300 1.00 69.26 ? 244 GLN A OE1 1 
ATOM 1511 N NE2 . GLN A 1 201 ? 133.479 106.471 136.625 1.00 59.58 ? 244 GLN A NE2 1 
ATOM 1512 N N   . GLU A 1 202 ? 130.858 105.159 134.618 1.00 61.08 ? 245 GLU A N   1 
ATOM 1513 C CA  . GLU A 1 202 ? 130.892 103.744 134.272 1.00 49.08 ? 245 GLU A CA  1 
ATOM 1514 C C   . GLU A 1 202 ? 131.369 102.945 135.478 1.00 46.04 ? 245 GLU A C   1 
ATOM 1515 O O   . GLU A 1 202 ? 132.461 103.190 136.001 1.00 53.65 ? 245 GLU A O   1 
ATOM 1516 C CB  . GLU A 1 202 ? 131.805 103.498 133.073 1.00 48.91 ? 245 GLU A CB  1 
ATOM 1517 C CG  . GLU A 1 202 ? 131.891 102.039 132.652 1.00 52.35 ? 245 GLU A CG  1 
ATOM 1518 C CD  . GLU A 1 202 ? 132.922 101.805 131.569 1.00 53.19 ? 245 GLU A CD  1 
ATOM 1519 O OE1 . GLU A 1 202 ? 133.515 102.793 131.090 1.00 62.19 ? 245 GLU A OE1 1 
ATOM 1520 O OE2 . GLU A 1 202 ? 133.141 100.635 131.194 1.00 48.29 ? 245 GLU A OE2 1 
ATOM 1521 N N   . THR A 1 203 ? 130.553 101.994 135.913 1.00 42.42 ? 246 THR A N   1 
ATOM 1522 C CA  . THR A 1 203 ? 130.871 101.161 137.061 1.00 47.37 ? 246 THR A CA  1 
ATOM 1523 C C   . THR A 1 203 ? 131.600 99.901  136.597 1.00 53.12 ? 246 THR A C   1 
ATOM 1524 O O   . THR A 1 203 ? 132.068 99.808  135.460 1.00 52.28 ? 246 THR A O   1 
ATOM 1525 C CB  . THR A 1 203 ? 129.601 100.837 137.844 1.00 52.96 ? 246 THR A CB  1 
ATOM 1526 O OG1 . THR A 1 203 ? 128.997 99.650  137.315 1.00 59.65 ? 246 THR A OG1 1 
ATOM 1527 C CG2 . THR A 1 203 ? 128.617 101.990 137.748 1.00 55.04 ? 246 THR A CG2 1 
ATOM 1528 N N   . SER A 1 204 ? 131.718 98.918  137.494 1.00 56.15 ? 247 SER A N   1 
ATOM 1529 C CA  . SER A 1 204 ? 132.422 97.684  137.158 1.00 53.78 ? 247 SER A CA  1 
ATOM 1530 C C   . SER A 1 204 ? 131.730 96.934  136.026 1.00 59.33 ? 247 SER A C   1 
ATOM 1531 O O   . SER A 1 204 ? 132.394 96.409  135.125 1.00 61.11 ? 247 SER A O   1 
ATOM 1532 C CB  . SER A 1 204 ? 132.538 96.794  138.394 1.00 54.06 ? 247 SER A CB  1 
ATOM 1533 O OG  . SER A 1 204 ? 131.265 96.532  138.954 1.00 56.68 ? 247 SER A OG  1 
ATOM 1534 N N   . ASP A 1 205 ? 130.397 96.868  136.052 1.00 59.10 ? 248 ASP A N   1 
ATOM 1535 C CA  . ASP A 1 205 ? 129.650 96.146  135.032 1.00 53.38 ? 248 ASP A CA  1 
ATOM 1536 C C   . ASP A 1 205 ? 128.471 96.912  134.442 1.00 60.38 ? 248 ASP A C   1 
ATOM 1537 O O   . ASP A 1 205 ? 127.749 96.350  133.611 1.00 62.98 ? 248 ASP A O   1 
ATOM 1538 C CB  . ASP A 1 205 ? 129.214 94.766  135.585 1.00 54.49 ? 248 ASP A CB  1 
ATOM 1539 C CG  . ASP A 1 205 ? 127.839 94.760  136.288 1.00 62.03 ? 248 ASP A CG  1 
ATOM 1540 O OD1 . ASP A 1 205 ? 127.505 93.700  136.858 1.00 63.66 ? 248 ASP A OD1 1 
ATOM 1541 O OD2 . ASP A 1 205 ? 127.112 95.772  136.354 1.00 64.17 ? 248 ASP A OD2 1 
ATOM 1542 N N   . SER A 1 206 ? 128.261 98.164  134.829 1.00 57.28 ? 249 SER A N   1 
ATOM 1543 C CA  . SER A 1 206 ? 127.145 98.946  134.311 1.00 51.13 ? 249 SER A CA  1 
ATOM 1544 C C   . SER A 1 206 ? 127.554 100.415 134.312 1.00 54.53 ? 249 SER A C   1 
ATOM 1545 O O   . SER A 1 206 ? 128.739 100.742 134.434 1.00 64.81 ? 249 SER A O   1 
ATOM 1546 C CB  . SER A 1 206 ? 125.875 98.677  135.135 1.00 53.93 ? 249 SER A CB  1 
ATOM 1547 O OG  . SER A 1 206 ? 125.482 97.320  135.035 1.00 60.86 ? 249 SER A OG  1 
ATOM 1548 N N   . ALA A 1 207 ? 126.573 101.304 134.174 1.00 51.90 ? 250 ALA A N   1 
ATOM 1549 C CA  . ALA A 1 207 ? 126.801 102.740 134.181 1.00 49.49 ? 250 ALA A CA  1 
ATOM 1550 C C   . ALA A 1 207 ? 125.830 103.403 135.147 1.00 52.72 ? 250 ALA A C   1 
ATOM 1551 O O   . ALA A 1 207 ? 124.781 102.849 135.484 1.00 58.96 ? 250 ALA A O   1 
ATOM 1552 C CB  . ALA A 1 207 ? 126.647 103.346 132.781 1.00 53.64 ? 250 ALA A CB  1 
ATOM 1553 N N   . GLN A 1 208 ? 126.190 104.605 135.588 1.00 47.60 ? 251 GLN A N   1 
ATOM 1554 C CA  . GLN A 1 208 ? 125.412 105.346 136.567 1.00 49.38 ? 251 GLN A CA  1 
ATOM 1555 C C   . GLN A 1 208 ? 125.060 106.729 136.037 1.00 56.00 ? 251 GLN A C   1 
ATOM 1556 O O   . GLN A 1 208 ? 125.815 107.329 135.266 1.00 58.81 ? 251 GLN A O   1 
ATOM 1557 C CB  . GLN A 1 208 ? 126.174 105.486 137.890 1.00 56.29 ? 251 GLN A CB  1 
ATOM 1558 C CG  . GLN A 1 208 ? 125.699 104.554 138.990 1.00 55.99 ? 251 GLN A CG  1 
ATOM 1559 C CD  . GLN A 1 208 ? 126.547 104.659 140.241 1.00 56.94 ? 251 GLN A CD  1 
ATOM 1560 O OE1 . GLN A 1 208 ? 127.537 105.388 140.272 1.00 56.47 ? 251 GLN A OE1 1 
ATOM 1561 N NE2 . GLN A 1 208 ? 126.163 103.930 141.281 1.00 58.05 ? 251 GLN A NE2 1 
ATOM 1562 N N   . VAL A 1 209 ? 123.902 107.228 136.462 1.00 55.51 ? 252 VAL A N   1 
ATOM 1563 C CA  . VAL A 1 209 ? 123.469 108.592 136.186 1.00 53.85 ? 252 VAL A CA  1 
ATOM 1564 C C   . VAL A 1 209 ? 123.021 109.217 137.501 1.00 58.76 ? 252 VAL A C   1 
ATOM 1565 O O   . VAL A 1 209 ? 122.501 108.522 138.382 1.00 56.65 ? 252 VAL A O   1 
ATOM 1566 C CB  . VAL A 1 209 ? 122.350 108.634 135.121 1.00 49.75 ? 252 VAL A CB  1 
ATOM 1567 C CG1 . VAL A 1 209 ? 121.001 108.275 135.723 1.00 56.64 ? 252 VAL A CG1 1 
ATOM 1568 C CG2 . VAL A 1 209 ? 122.305 109.995 134.448 1.00 50.71 ? 252 VAL A CG2 1 
ATOM 1569 N N   . SER A 1 210 ? 123.250 110.521 137.651 1.00 59.32 ? 253 SER A N   1 
ATOM 1570 C CA  . SER A 1 210 ? 123.056 111.160 138.944 1.00 56.00 ? 253 SER A CA  1 
ATOM 1571 C C   . SER A 1 210 ? 122.687 112.626 138.769 1.00 59.27 ? 253 SER A C   1 
ATOM 1572 O O   . SER A 1 210 ? 122.853 113.212 137.697 1.00 57.72 ? 253 SER A O   1 
ATOM 1573 C CB  . SER A 1 210 ? 124.311 111.041 139.817 1.00 59.30 ? 253 SER A CB  1 
ATOM 1574 O OG  . SER A 1 210 ? 124.243 109.902 140.654 1.00 63.25 ? 253 SER A OG  1 
ATOM 1575 N N   . ILE A 1 211 ? 122.181 113.206 139.857 1.00 54.71 ? 254 ILE A N   1 
ATOM 1576 C CA  . ILE A 1 211 ? 121.832 114.617 139.950 1.00 50.08 ? 254 ILE A CA  1 
ATOM 1577 C C   . ILE A 1 211 ? 122.561 115.210 141.148 1.00 49.97 ? 254 ILE A C   1 
ATOM 1578 O O   . ILE A 1 211 ? 122.772 114.542 142.165 1.00 52.01 ? 254 ILE A O   1 
ATOM 1579 C CB  . ILE A 1 211 ? 120.298 114.823 140.056 1.00 52.38 ? 254 ILE A CB  1 
ATOM 1580 C CG1 . ILE A 1 211 ? 119.875 116.157 139.441 1.00 49.29 ? 254 ILE A CG1 1 
ATOM 1581 C CG2 . ILE A 1 211 ? 119.813 114.724 141.488 1.00 52.19 ? 254 ILE A CG2 1 
ATOM 1582 C CD1 . ILE A 1 211 ? 120.407 116.391 138.069 1.00 55.67 ? 254 ILE A CD1 1 
ATOM 1583 N N   . GLY A 1 212 ? 122.988 116.463 141.009 1.00 46.59 ? 255 GLY A N   1 
ATOM 1584 C CA  . GLY A 1 212 ? 123.723 117.122 142.073 1.00 45.77 ? 255 GLY A CA  1 
ATOM 1585 C C   . GLY A 1 212 ? 123.640 118.634 142.039 1.00 48.56 ? 255 GLY A C   1 
ATOM 1586 O O   . GLY A 1 212 ? 123.630 119.236 140.961 1.00 50.30 ? 255 GLY A O   1 
ATOM 1587 N N   . TRP A 1 213 ? 123.586 119.259 143.207 1.00 47.19 ? 256 TRP A N   1 
ATOM 1588 C CA  . TRP A 1 213 ? 123.497 120.703 143.342 1.00 41.19 ? 256 TRP A CA  1 
ATOM 1589 C C   . TRP A 1 213 ? 124.548 121.193 144.323 1.00 42.20 ? 256 TRP A C   1 
ATOM 1590 O O   . TRP A 1 213 ? 124.996 120.440 145.194 1.00 51.70 ? 256 TRP A O   1 
ATOM 1591 C CB  . TRP A 1 213 ? 122.109 121.142 143.834 1.00 44.21 ? 256 TRP A CB  1 
ATOM 1592 C CG  . TRP A 1 213 ? 120.966 120.399 143.230 1.00 43.17 ? 256 TRP A CG  1 
ATOM 1593 C CD1 . TRP A 1 213 ? 120.215 120.782 142.163 1.00 43.86 ? 256 TRP A CD1 1 
ATOM 1594 C CD2 . TRP A 1 213 ? 120.412 119.164 143.689 1.00 44.09 ? 256 TRP A CD2 1 
ATOM 1595 N NE1 . TRP A 1 213 ? 119.241 119.849 141.910 1.00 47.07 ? 256 TRP A NE1 1 
ATOM 1596 C CE2 . TRP A 1 213 ? 119.339 118.846 142.836 1.00 36.49 ? 256 TRP A CE2 1 
ATOM 1597 C CE3 . TRP A 1 213 ? 120.725 118.289 144.733 1.00 55.86 ? 256 TRP A CE3 1 
ATOM 1598 C CZ2 . TRP A 1 213 ? 118.579 117.694 142.994 1.00 42.94 ? 256 TRP A CZ2 1 
ATOM 1599 C CZ3 . TRP A 1 213 ? 119.969 117.145 144.888 1.00 57.01 ? 256 TRP A CZ3 1 
ATOM 1600 C CH2 . TRP A 1 213 ? 118.907 116.859 144.025 1.00 53.54 ? 256 TRP A CH2 1 
ATOM 1601 N N   . PRO A 1 214 ? 124.968 122.450 144.205 1.00 50.28 ? 257 PRO A N   1 
ATOM 1602 C CA  . PRO A 1 214 ? 125.858 123.028 145.217 1.00 52.54 ? 257 PRO A CA  1 
ATOM 1603 C C   . PRO A 1 214 ? 125.137 123.217 146.543 1.00 57.09 ? 257 PRO A C   1 
ATOM 1604 O O   . PRO A 1 214 ? 123.907 123.252 146.620 1.00 61.65 ? 257 PRO A O   1 
ATOM 1605 C CB  . PRO A 1 214 ? 126.267 124.375 144.612 1.00 45.50 ? 257 PRO A CB  1 
ATOM 1606 C CG  . PRO A 1 214 ? 125.976 124.252 143.158 1.00 49.52 ? 257 PRO A CG  1 
ATOM 1607 C CD  . PRO A 1 214 ? 124.791 123.348 143.054 1.00 50.84 ? 257 PRO A CD  1 
ATOM 1608 N N   . GLY A 1 215 ? 125.935 123.339 147.608 1.00 52.68 ? 258 GLY A N   1 
ATOM 1609 C CA  . GLY A 1 215 ? 125.418 123.465 148.951 1.00 54.99 ? 258 GLY A CA  1 
ATOM 1610 C C   . GLY A 1 215 ? 125.935 124.713 149.651 1.00 52.81 ? 258 GLY A C   1 
ATOM 1611 O O   . GLY A 1 215 ? 126.795 125.439 149.140 1.00 56.65 ? 258 GLY A O   1 
ATOM 1612 N N   . LYS A 1 216 ? 125.392 124.950 150.843 1.00 52.04 ? 259 LYS A N   1 
ATOM 1613 C CA  . LYS A 1 216 ? 125.772 126.099 151.651 1.00 57.49 ? 259 LYS A CA  1 
ATOM 1614 C C   . LYS A 1 216 ? 125.612 125.743 153.122 1.00 60.39 ? 259 LYS A C   1 
ATOM 1615 O O   . LYS A 1 216 ? 125.049 124.704 153.475 1.00 63.33 ? 259 LYS A O   1 
ATOM 1616 C CB  . LYS A 1 216 ? 124.947 127.339 151.288 1.00 62.93 ? 259 LYS A CB  1 
ATOM 1617 C CG  . LYS A 1 216 ? 123.447 127.108 151.234 1.00 61.58 ? 259 LYS A CG  1 
ATOM 1618 C CD  . LYS A 1 216 ? 122.721 128.375 150.803 1.00 63.48 ? 259 LYS A CD  1 
ATOM 1619 C CE  . LYS A 1 216 ? 121.232 128.135 150.627 1.00 62.06 ? 259 LYS A CE  1 
ATOM 1620 N NZ  . LYS A 1 216 ? 120.950 127.191 149.510 1.00 61.32 ? 259 LYS A NZ  1 
ATOM 1621 N N   . VAL A 1 217 ? 126.124 126.627 153.982 1.00 63.40 ? 260 VAL A N   1 
ATOM 1622 C CA  . VAL A 1 217 ? 126.148 126.360 155.415 1.00 60.14 ? 260 VAL A CA  1 
ATOM 1623 C C   . VAL A 1 217 ? 124.726 126.258 155.946 1.00 57.01 ? 260 VAL A C   1 
ATOM 1624 O O   . VAL A 1 217 ? 123.873 127.108 155.663 1.00 61.66 ? 260 VAL A O   1 
ATOM 1625 C CB  . VAL A 1 217 ? 126.947 127.452 156.143 1.00 62.25 ? 260 VAL A CB  1 
ATOM 1626 C CG1 . VAL A 1 217 ? 126.452 127.627 157.573 1.00 62.39 ? 260 VAL A CG1 1 
ATOM 1627 C CG2 . VAL A 1 217 ? 128.431 127.122 156.126 1.00 59.95 ? 260 VAL A CG2 1 
ATOM 1628 N N   . ILE A 1 218 ? 124.466 125.208 156.717 1.00 56.48 ? 261 ILE A N   1 
ATOM 1629 C CA  . ILE A 1 218 ? 123.160 124.967 157.317 1.00 59.15 ? 261 ILE A CA  1 
ATOM 1630 C C   . ILE A 1 218 ? 123.250 125.357 158.787 1.00 63.59 ? 261 ILE A C   1 
ATOM 1631 O O   . ILE A 1 218 ? 123.992 124.741 159.559 1.00 64.45 ? 261 ILE A O   1 
ATOM 1632 C CB  . ILE A 1 218 ? 122.725 123.506 157.153 1.00 58.67 ? 261 ILE A CB  1 
ATOM 1633 C CG1 . ILE A 1 218 ? 122.880 123.065 155.696 1.00 62.34 ? 261 ILE A CG1 1 
ATOM 1634 C CG2 . ILE A 1 218 ? 121.292 123.320 157.620 1.00 56.92 ? 261 ILE A CG2 1 
ATOM 1635 C CD1 . ILE A 1 218 ? 122.518 121.619 155.453 1.00 61.33 ? 261 ILE A CD1 1 
ATOM 1636 N N   . ALA A 1 219 ? 122.495 126.380 159.177 1.00 62.82 ? 262 ALA A N   1 
ATOM 1637 C CA  . ALA A 1 219 ? 122.487 126.817 160.563 1.00 59.07 ? 262 ALA A CA  1 
ATOM 1638 C C   . ALA A 1 219 ? 121.696 125.841 161.428 1.00 60.40 ? 262 ALA A C   1 
ATOM 1639 O O   . ALA A 1 219 ? 120.859 125.074 160.944 1.00 65.78 ? 262 ALA A O   1 
ATOM 1640 C CB  . ALA A 1 219 ? 121.897 128.222 160.680 1.00 61.42 ? 262 ALA A CB  1 
ATOM 1641 N N   . ALA A 1 220 ? 121.978 125.874 162.728 1.00 50.89 ? 263 ALA A N   1 
ATOM 1642 C CA  . ALA A 1 220 ? 121.294 124.996 163.666 1.00 55.00 ? 263 ALA A CA  1 
ATOM 1643 C C   . ALA A 1 220 ? 119.812 125.343 163.735 1.00 56.69 ? 263 ALA A C   1 
ATOM 1644 O O   . ALA A 1 220 ? 119.441 126.517 163.820 1.00 60.69 ? 263 ALA A O   1 
ATOM 1645 C CB  . ALA A 1 220 ? 121.929 125.101 165.051 1.00 58.21 ? 263 ALA A CB  1 
ATOM 1646 N N   . GLY A 1 221 ? 118.965 124.316 163.700 1.00 55.83 ? 264 GLY A N   1 
ATOM 1647 C CA  . GLY A 1 221 ? 117.534 124.529 163.767 1.00 51.89 ? 264 GLY A CA  1 
ATOM 1648 C C   . GLY A 1 221 ? 116.911 125.079 162.506 1.00 57.13 ? 264 GLY A C   1 
ATOM 1649 O O   . GLY A 1 221 ? 115.806 125.624 162.561 1.00 59.04 ? 264 GLY A O   1 
ATOM 1650 N N   . SER A 1 222 ? 117.584 124.950 161.365 1.00 61.75 ? 265 SER A N   1 
ATOM 1651 C CA  . SER A 1 222 ? 117.114 125.503 160.104 1.00 59.99 ? 265 SER A CA  1 
ATOM 1652 C C   . SER A 1 222 ? 116.811 124.382 159.120 1.00 61.03 ? 265 SER A C   1 
ATOM 1653 O O   . SER A 1 222 ? 117.506 123.362 159.092 1.00 61.83 ? 265 SER A O   1 
ATOM 1654 C CB  . SER A 1 222 ? 118.147 126.458 159.501 1.00 57.77 ? 265 SER A CB  1 
ATOM 1655 O OG  . SER A 1 222 ? 119.376 125.796 159.265 1.00 60.66 ? 265 SER A OG  1 
ATOM 1656 N N   . VAL A 1 223 ? 115.770 124.580 158.315 1.00 55.14 ? 266 VAL A N   1 
ATOM 1657 C CA  . VAL A 1 223 ? 115.367 123.639 157.277 1.00 51.52 ? 266 VAL A CA  1 
ATOM 1658 C C   . VAL A 1 223 ? 115.641 124.280 155.925 1.00 51.02 ? 266 VAL A C   1 
ATOM 1659 O O   . VAL A 1 223 ? 115.198 125.404 155.663 1.00 57.02 ? 266 VAL A O   1 
ATOM 1660 C CB  . VAL A 1 223 ? 113.885 123.250 157.410 1.00 56.27 ? 266 VAL A CB  1 
ATOM 1661 C CG1 . VAL A 1 223 ? 113.620 121.925 156.714 1.00 57.28 ? 266 VAL A CG1 1 
ATOM 1662 C CG2 . VAL A 1 223 ? 113.485 123.180 158.873 1.00 56.35 ? 266 VAL A CG2 1 
ATOM 1663 N N   . ILE A 1 224 ? 116.368 123.567 155.069 1.00 48.79 ? 267 ILE A N   1 
ATOM 1664 C CA  . ILE A 1 224 ? 116.785 124.078 153.770 1.00 49.85 ? 267 ILE A CA  1 
ATOM 1665 C C   . ILE A 1 224 ? 116.393 123.076 152.693 1.00 55.71 ? 267 ILE A C   1 
ATOM 1666 O O   . ILE A 1 224 ? 116.535 121.862 152.876 1.00 56.56 ? 267 ILE A O   1 
ATOM 1667 C CB  . ILE A 1 224 ? 118.303 124.365 153.736 1.00 54.45 ? 267 ILE A CB  1 
ATOM 1668 C CG1 . ILE A 1 224 ? 118.716 124.941 152.380 1.00 56.58 ? 267 ILE A CG1 1 
ATOM 1669 C CG2 . ILE A 1 224 ? 119.105 123.115 154.081 1.00 57.29 ? 267 ILE A CG2 1 
ATOM 1670 C CD1 . ILE A 1 224 ? 120.214 125.018 152.178 1.00 52.68 ? 267 ILE A CD1 1 
ATOM 1671 N N   . GLU A 1 225 ? 115.875 123.586 151.579 1.00 57.26 ? 268 GLU A N   1 
ATOM 1672 C CA  . GLU A 1 225 ? 115.538 122.771 150.420 1.00 50.40 ? 268 GLU A CA  1 
ATOM 1673 C C   . GLU A 1 225 ? 116.681 122.835 149.418 1.00 53.24 ? 268 GLU A C   1 
ATOM 1674 O O   . GLU A 1 225 ? 117.157 123.923 149.081 1.00 57.10 ? 268 GLU A O   1 
ATOM 1675 C CB  . GLU A 1 225 ? 114.238 123.246 149.773 1.00 55.59 ? 268 GLU A CB  1 
ATOM 1676 C CG  . GLU A 1 225 ? 113.026 122.407 150.132 1.00 62.00 ? 268 GLU A CG  1 
ATOM 1677 C CD  . GLU A 1 225 ? 111.810 123.251 150.450 1.00 63.05 ? 268 GLU A CD  1 
ATOM 1678 O OE1 . GLU A 1 225 ? 111.782 124.432 150.045 1.00 61.94 ? 268 GLU A OE1 1 
ATOM 1679 O OE2 . GLU A 1 225 ? 110.882 122.735 151.106 1.00 62.82 ? 268 GLU A OE2 1 
ATOM 1680 N N   . ILE A 1 226 ? 117.114 121.670 148.942 1.00 54.04 ? 269 ILE A N   1 
ATOM 1681 C CA  . ILE A 1 226 ? 118.295 121.578 148.090 1.00 52.18 ? 269 ILE A CA  1 
ATOM 1682 C C   . ILE A 1 226 ? 117.912 121.752 146.627 1.00 55.39 ? 269 ILE A C   1 
ATOM 1683 O O   . ILE A 1 226 ? 118.370 122.686 145.961 1.00 54.33 ? 269 ILE A O   1 
ATOM 1684 C CB  . ILE A 1 226 ? 119.037 120.243 148.291 1.00 53.66 ? 269 ILE A CB  1 
ATOM 1685 C CG1 . ILE A 1 226 ? 119.055 119.799 149.762 1.00 53.45 ? 269 ILE A CG1 1 
ATOM 1686 C CG2 . ILE A 1 226 ? 120.438 120.344 147.734 1.00 55.85 ? 269 ILE A CG2 1 
ATOM 1687 C CD1 . ILE A 1 226 ? 119.398 120.889 150.773 1.00 57.66 ? 269 ILE A CD1 1 
ATOM 1688 N N   . GLY A 1 227 ? 117.081 120.852 146.119 1.00 56.37 ? 270 GLY A N   1 
ATOM 1689 C CA  . GLY A 1 227 ? 116.696 120.905 144.722 1.00 53.21 ? 270 GLY A CA  1 
ATOM 1690 C C   . GLY A 1 227 ? 115.724 119.793 144.403 1.00 50.35 ? 270 GLY A C   1 
ATOM 1691 O O   . GLY A 1 227 ? 115.387 118.964 145.254 1.00 55.91 ? 270 GLY A O   1 
ATOM 1692 N N   . GLU A 1 228 ? 115.275 119.790 143.152 1.00 42.87 ? 271 GLU A N   1 
ATOM 1693 C CA  . GLU A 1 228 ? 114.314 118.808 142.677 1.00 47.00 ? 271 GLU A CA  1 
ATOM 1694 C C   . GLU A 1 228 ? 114.769 118.283 141.324 1.00 49.83 ? 271 GLU A C   1 
ATOM 1695 O O   . GLU A 1 228 ? 115.498 118.954 140.590 1.00 55.84 ? 271 GLU A O   1 
ATOM 1696 C CB  . GLU A 1 228 ? 112.904 119.402 142.579 1.00 51.91 ? 271 GLU A CB  1 
ATOM 1697 C CG  . GLU A 1 228 ? 112.325 119.833 143.914 1.00 52.15 ? 271 GLU A CG  1 
ATOM 1698 C CD  . GLU A 1 228 ? 112.733 121.241 144.299 1.00 57.79 ? 271 GLU A CD  1 
ATOM 1699 O OE1 . GLU A 1 228 ? 113.174 121.998 143.410 1.00 54.64 ? 271 GLU A OE1 1 
ATOM 1700 O OE2 . GLU A 1 228 ? 112.615 121.590 145.492 1.00 62.29 ? 271 GLU A OE2 1 
ATOM 1701 N N   . SER A 1 229 ? 114.330 117.069 140.999 1.00 41.05 ? 272 SER A N   1 
ATOM 1702 C CA  . SER A 1 229 ? 114.762 116.421 139.771 1.00 40.74 ? 272 SER A CA  1 
ATOM 1703 C C   . SER A 1 229 ? 113.651 115.525 139.244 1.00 47.94 ? 272 SER A C   1 
ATOM 1704 O O   . SER A 1 229 ? 112.733 115.142 139.974 1.00 46.16 ? 272 SER A O   1 
ATOM 1705 C CB  . SER A 1 229 ? 116.044 115.608 139.986 1.00 44.20 ? 272 SER A CB  1 
ATOM 1706 O OG  . SER A 1 229 ? 115.841 114.580 140.939 1.00 52.66 ? 272 SER A OG  1 
ATOM 1707 N N   . PHE A 1 230 ? 113.753 115.196 137.959 1.00 56.32 ? 273 PHE A N   1 
ATOM 1708 C CA  . PHE A 1 230 ? 112.808 114.326 137.272 1.00 51.57 ? 273 PHE A CA  1 
ATOM 1709 C C   . PHE A 1 230 ? 113.517 113.049 136.846 1.00 47.31 ? 273 PHE A C   1 
ATOM 1710 O O   . PHE A 1 230 ? 114.608 113.104 136.271 1.00 49.02 ? 273 PHE A O   1 
ATOM 1711 C CB  . PHE A 1 230 ? 112.211 115.021 136.046 1.00 48.43 ? 273 PHE A CB  1 
ATOM 1712 C CG  . PHE A 1 230 ? 111.005 115.860 136.348 1.00 48.31 ? 273 PHE A CG  1 
ATOM 1713 C CD1 . PHE A 1 230 ? 110.002 115.383 137.170 1.00 45.55 ? 273 PHE A CD1 1 
ATOM 1714 C CD2 . PHE A 1 230 ? 110.872 117.124 135.804 1.00 46.05 ? 273 PHE A CD2 1 
ATOM 1715 C CE1 . PHE A 1 230 ? 108.893 116.153 137.446 1.00 42.08 ? 273 PHE A CE1 1 
ATOM 1716 C CE2 . PHE A 1 230 ? 109.765 117.897 136.077 1.00 47.80 ? 273 PHE A CE2 1 
ATOM 1717 C CZ  . PHE A 1 230 ? 108.775 117.410 136.898 1.00 44.03 ? 273 PHE A CZ  1 
ATOM 1718 N N   . ALA A 1 231 ? 112.896 111.907 137.123 1.00 46.48 ? 274 ALA A N   1 
ATOM 1719 C CA  . ALA A 1 231 ? 113.414 110.608 136.716 1.00 44.78 ? 274 ALA A CA  1 
ATOM 1720 C C   . ALA A 1 231 ? 112.463 109.986 135.704 1.00 47.06 ? 274 ALA A C   1 
ATOM 1721 O O   . ALA A 1 231 ? 111.265 109.853 135.974 1.00 49.68 ? 274 ALA A O   1 
ATOM 1722 C CB  . ALA A 1 231 ? 113.587 109.683 137.922 1.00 47.13 ? 274 ALA A CB  1 
ATOM 1723 N N   . VAL A 1 232 ? 112.996 109.607 134.546 1.00 48.47 ? 275 VAL A N   1 
ATOM 1724 C CA  . VAL A 1 232 ? 112.206 109.046 133.456 1.00 36.85 ? 275 VAL A CA  1 
ATOM 1725 C C   . VAL A 1 232 ? 112.710 107.639 133.171 1.00 39.85 ? 275 VAL A C   1 
ATOM 1726 O O   . VAL A 1 232 ? 113.869 107.456 132.780 1.00 50.22 ? 275 VAL A O   1 
ATOM 1727 C CB  . VAL A 1 232 ? 112.278 109.917 132.192 1.00 38.56 ? 275 VAL A CB  1 
ATOM 1728 C CG1 . VAL A 1 232 ? 111.214 109.494 131.195 1.00 47.19 ? 275 VAL A CG1 1 
ATOM 1729 C CG2 . VAL A 1 232 ? 112.124 111.385 132.548 1.00 44.02 ? 275 VAL A CG2 1 
ATOM 1730 N N   . VAL A 1 233 ? 111.840 106.651 133.359 1.00 31.95 ? 276 VAL A N   1 
ATOM 1731 C CA  . VAL A 1 233 ? 112.113 105.265 132.998 1.00 29.35 ? 276 VAL A CA  1 
ATOM 1732 C C   . VAL A 1 233 ? 111.277 104.948 131.768 1.00 42.49 ? 276 VAL A C   1 
ATOM 1733 O O   . VAL A 1 233 ? 110.041 104.971 131.828 1.00 51.00 ? 276 VAL A O   1 
ATOM 1734 C CB  . VAL A 1 233 ? 111.793 104.302 134.150 1.00 31.94 ? 276 VAL A CB  1 
ATOM 1735 C CG1 . VAL A 1 233 ? 112.300 102.909 133.832 1.00 45.52 ? 276 VAL A CG1 1 
ATOM 1736 C CG2 . VAL A 1 233 ? 112.398 104.809 135.445 1.00 46.82 ? 276 VAL A CG2 1 
ATOM 1737 N N   . HIS A 1 234 ? 111.940 104.652 130.660 1.00 42.07 ? 277 HIS A N   1 
ATOM 1738 C CA  . HIS A 1 234 ? 111.293 104.602 129.360 1.00 37.72 ? 277 HIS A CA  1 
ATOM 1739 C C   . HIS A 1 234 ? 111.765 103.385 128.584 1.00 41.64 ? 277 HIS A C   1 
ATOM 1740 O O   . HIS A 1 234 ? 112.859 102.867 128.830 1.00 45.59 ? 277 HIS A O   1 
ATOM 1741 C CB  . HIS A 1 234 ? 111.593 105.870 128.552 1.00 38.45 ? 277 HIS A CB  1 
ATOM 1742 C CG  . HIS A 1 234 ? 113.050 106.086 128.297 1.00 37.07 ? 277 HIS A CG  1 
ATOM 1743 N ND1 . HIS A 1 234 ? 113.725 105.468 127.267 1.00 41.03 ? 277 HIS A ND1 1 
ATOM 1744 C CD2 . HIS A 1 234 ? 113.965 106.846 128.943 1.00 39.75 ? 277 HIS A CD2 1 
ATOM 1745 C CE1 . HIS A 1 234 ? 114.991 105.841 127.287 1.00 45.06 ? 277 HIS A CE1 1 
ATOM 1746 N NE2 . HIS A 1 234 ? 115.163 106.677 128.294 1.00 44.53 ? 277 HIS A NE2 1 
ATOM 1747 N N   . PRO A 1 235 ? 110.954 102.899 127.644 1.00 42.70 ? 278 PRO A N   1 
ATOM 1748 C CA  . PRO A 1 235 ? 111.434 101.899 126.688 1.00 30.29 ? 278 PRO A CA  1 
ATOM 1749 C C   . PRO A 1 235 ? 111.974 102.546 125.422 1.00 34.03 ? 278 PRO A C   1 
ATOM 1750 O O   . PRO A 1 235 ? 111.427 103.520 124.903 1.00 40.55 ? 278 PRO A O   1 
ATOM 1751 C CB  . PRO A 1 235 ? 110.171 101.083 126.388 1.00 30.09 ? 278 PRO A CB  1 
ATOM 1752 C CG  . PRO A 1 235 ? 109.057 102.062 126.543 1.00 31.76 ? 278 PRO A CG  1 
ATOM 1753 C CD  . PRO A 1 235 ? 109.504 103.131 127.517 1.00 40.71 ? 278 PRO A CD  1 
ATOM 1754 N N   . GLY A 1 236 ? 113.073 101.991 124.923 1.00 38.85 ? 279 GLY A N   1 
ATOM 1755 C CA  . GLY A 1 236 ? 113.653 102.477 123.689 1.00 38.50 ? 279 GLY A CA  1 
ATOM 1756 C C   . GLY A 1 236 ? 114.934 103.262 123.866 1.00 39.72 ? 279 GLY A C   1 
ATOM 1757 O O   . GLY A 1 236 ? 115.844 102.833 124.582 1.00 46.41 ? 279 GLY A O   1 
ATOM 1758 N N   . ASP A 1 237 ? 115.016 104.415 123.215 1.00 35.35 ? 280 ASP A N   1 
ATOM 1759 C CA  . ASP A 1 237 ? 116.216 105.237 123.180 1.00 37.78 ? 280 ASP A CA  1 
ATOM 1760 C C   . ASP A 1 237 ? 115.930 106.626 123.757 1.00 47.01 ? 280 ASP A C   1 
ATOM 1761 O O   . ASP A 1 237 ? 114.874 106.875 124.344 1.00 50.14 ? 280 ASP A O   1 
ATOM 1762 C CB  . ASP A 1 237 ? 116.788 105.272 121.755 1.00 40.79 ? 280 ASP A CB  1 
ATOM 1763 C CG  . ASP A 1 237 ? 116.000 106.166 120.801 1.00 49.48 ? 280 ASP A CG  1 
ATOM 1764 O OD1 . ASP A 1 237 ? 114.989 106.781 121.197 1.00 54.23 ? 280 ASP A OD1 1 
ATOM 1765 O OD2 . ASP A 1 237 ? 116.408 106.251 119.623 1.00 51.36 ? 280 ASP A OD2 1 
ATOM 1766 N N   . TYR A 1 238 ? 116.898 107.530 123.586 1.00 46.86 ? 281 TYR A N   1 
ATOM 1767 C CA  . TYR A 1 238 ? 116.841 108.850 124.207 1.00 43.32 ? 281 TYR A CA  1 
ATOM 1768 C C   . TYR A 1 238 ? 115.644 109.675 123.754 1.00 48.88 ? 281 TYR A C   1 
ATOM 1769 O O   . TYR A 1 238 ? 115.270 110.630 124.446 1.00 51.69 ? 281 TYR A O   1 
ATOM 1770 C CB  . TYR A 1 238 ? 118.133 109.617 123.921 1.00 40.67 ? 281 TYR A CB  1 
ATOM 1771 C CG  . TYR A 1 238 ? 118.428 109.813 122.452 1.00 33.25 ? 281 TYR A CG  1 
ATOM 1772 C CD1 . TYR A 1 238 ? 118.994 108.799 121.695 1.00 40.96 ? 281 TYR A CD1 1 
ATOM 1773 C CD2 . TYR A 1 238 ? 118.149 111.017 121.825 1.00 45.74 ? 281 TYR A CD2 1 
ATOM 1774 C CE1 . TYR A 1 238 ? 119.264 108.974 120.355 1.00 48.90 ? 281 TYR A CE1 1 
ATOM 1775 C CE2 . TYR A 1 238 ? 118.418 111.203 120.486 1.00 46.07 ? 281 TYR A CE2 1 
ATOM 1776 C CZ  . TYR A 1 238 ? 118.977 110.178 119.755 1.00 50.63 ? 281 TYR A CZ  1 
ATOM 1777 O OH  . TYR A 1 238 ? 119.249 110.359 118.419 1.00 52.62 ? 281 TYR A OH  1 
ATOM 1778 N N   . TYR A 1 239 ? 115.042 109.342 122.610 1.00 40.86 ? 282 TYR A N   1 
ATOM 1779 C CA  . TYR A 1 239 ? 113.861 110.067 122.152 1.00 35.91 ? 282 TYR A CA  1 
ATOM 1780 C C   . TYR A 1 239 ? 112.742 109.989 123.182 1.00 34.89 ? 282 TYR A C   1 
ATOM 1781 O O   . TYR A 1 239 ? 112.128 111.006 123.531 1.00 47.92 ? 282 TYR A O   1 
ATOM 1782 C CB  . TYR A 1 239 ? 113.397 109.504 120.807 1.00 42.47 ? 282 TYR A CB  1 
ATOM 1783 C CG  . TYR A 1 239 ? 112.236 110.239 120.176 1.00 47.55 ? 282 TYR A CG  1 
ATOM 1784 C CD1 . TYR A 1 239 ? 112.449 111.313 119.324 1.00 46.69 ? 282 TYR A CD1 1 
ATOM 1785 C CD2 . TYR A 1 239 ? 110.926 109.852 120.425 1.00 48.05 ? 282 TYR A CD2 1 
ATOM 1786 C CE1 . TYR A 1 239 ? 111.392 111.984 118.744 1.00 43.07 ? 282 TYR A CE1 1 
ATOM 1787 C CE2 . TYR A 1 239 ? 109.863 110.518 119.850 1.00 45.10 ? 282 TYR A CE2 1 
ATOM 1788 C CZ  . TYR A 1 239 ? 110.102 111.582 119.010 1.00 45.97 ? 282 TYR A CZ  1 
ATOM 1789 O OH  . TYR A 1 239 ? 109.046 112.249 118.433 1.00 53.60 ? 282 TYR A OH  1 
ATOM 1790 N N   . ASN A 1 240 ? 112.472 108.785 123.690 1.00 26.73 ? 283 ASN A N   1 
ATOM 1791 C CA  . ASN A 1 240 ? 111.400 108.614 124.664 1.00 37.32 ? 283 ASN A CA  1 
ATOM 1792 C C   . ASN A 1 240 ? 111.704 109.358 125.956 1.00 42.84 ? 283 ASN A C   1 
ATOM 1793 O O   . ASN A 1 240 ? 110.814 109.985 126.544 1.00 48.94 ? 283 ASN A O   1 
ATOM 1794 C CB  . ASN A 1 240 ? 111.176 107.128 124.938 1.00 37.85 ? 283 ASN A CB  1 
ATOM 1795 C CG  . ASN A 1 240 ? 110.696 106.377 123.714 1.00 34.29 ? 283 ASN A CG  1 
ATOM 1796 O OD1 . ASN A 1 240 ? 109.499 106.159 123.536 1.00 37.47 ? 283 ASN A OD1 1 
ATOM 1797 N ND2 . ASN A 1 240 ? 111.630 105.976 122.862 1.00 40.02 ? 283 ASN A ND2 1 
ATOM 1798 N N   . GLY A 1 241 ? 112.956 109.305 126.413 1.00 50.71 ? 284 GLY A N   1 
ATOM 1799 C CA  . GLY A 1 241 ? 113.315 110.006 127.635 1.00 46.36 ? 284 GLY A CA  1 
ATOM 1800 C C   . GLY A 1 241 ? 113.174 111.510 127.509 1.00 49.70 ? 284 GLY A C   1 
ATOM 1801 O O   . GLY A 1 241 ? 112.636 112.169 128.403 1.00 59.74 ? 284 GLY A O   1 
ATOM 1802 N N   . LEU A 1 242 ? 113.648 112.073 126.396 1.00 38.82 ? 285 LEU A N   1 
ATOM 1803 C CA  . LEU A 1 242 ? 113.524 113.513 126.194 1.00 23.89 ? 285 LEU A CA  1 
ATOM 1804 C C   . LEU A 1 242 ? 112.064 113.928 126.047 1.00 28.59 ? 285 LEU A C   1 
ATOM 1805 O O   . LEU A 1 242 ? 111.660 114.981 126.557 1.00 38.77 ? 285 LEU A O   1 
ATOM 1806 C CB  . LEU A 1 242 ? 114.337 113.947 124.976 1.00 31.08 ? 285 LEU A CB  1 
ATOM 1807 C CG  . LEU A 1 242 ? 115.862 113.830 125.070 1.00 33.27 ? 285 LEU A CG  1 
ATOM 1808 C CD1 . LEU A 1 242 ? 116.536 114.900 124.230 1.00 40.65 ? 285 LEU A CD1 1 
ATOM 1809 C CD2 . LEU A 1 242 ? 116.334 113.913 126.506 1.00 30.07 ? 285 LEU A CD2 1 
ATOM 1810 N N   . ARG A 1 243 ? 111.254 113.116 125.362 1.00 32.42 ? 286 ARG A N   1 
ATOM 1811 C CA  . ARG A 1 243 ? 109.835 113.431 125.240 1.00 35.41 ? 286 ARG A CA  1 
ATOM 1812 C C   . ARG A 1 243 ? 109.146 113.402 126.598 1.00 38.04 ? 286 ARG A C   1 
ATOM 1813 O O   . ARG A 1 243 ? 108.340 114.288 126.914 1.00 48.10 ? 286 ARG A O   1 
ATOM 1814 C CB  . ARG A 1 243 ? 109.163 112.457 124.273 1.00 37.10 ? 286 ARG A CB  1 
ATOM 1815 C CG  . ARG A 1 243 ? 107.661 112.637 124.148 1.00 41.37 ? 286 ARG A CG  1 
ATOM 1816 C CD  . ARG A 1 243 ? 107.313 113.986 123.546 1.00 43.21 ? 286 ARG A CD  1 
ATOM 1817 N NE  . ARG A 1 243 ? 107.069 113.898 122.112 1.00 41.85 ? 286 ARG A NE  1 
ATOM 1818 C CZ  . ARG A 1 243 ? 107.718 114.606 121.198 1.00 37.72 ? 286 ARG A CZ  1 
ATOM 1819 N NH1 . ARG A 1 243 ? 108.659 115.471 121.535 1.00 39.11 ? 286 ARG A NH1 1 
ATOM 1820 N NH2 . ARG A 1 243 ? 107.413 114.444 119.914 1.00 36.16 ? 286 ARG A NH2 1 
ATOM 1821 N N   . GLY A 1 244 ? 109.454 112.395 127.417 1.00 30.87 ? 287 GLY A N   1 
ATOM 1822 C CA  . GLY A 1 244 ? 108.887 112.345 128.753 1.00 35.80 ? 287 GLY A CA  1 
ATOM 1823 C C   . GLY A 1 244 ? 109.321 113.518 129.609 1.00 39.15 ? 287 GLY A C   1 
ATOM 1824 O O   . GLY A 1 244 ? 108.528 114.065 130.376 1.00 48.02 ? 287 GLY A O   1 
ATOM 1825 N N   . TYR A 1 245 ? 110.586 113.924 129.484 1.00 38.47 ? 288 TYR A N   1 
ATOM 1826 C CA  . TYR A 1 245 ? 111.073 115.079 130.230 1.00 32.50 ? 288 TYR A CA  1 
ATOM 1827 C C   . TYR A 1 245 ? 110.349 116.353 129.815 1.00 42.34 ? 288 TYR A C   1 
ATOM 1828 O O   . TYR A 1 245 ? 109.985 117.175 130.666 1.00 47.72 ? 288 TYR A O   1 
ATOM 1829 C CB  . TYR A 1 245 ? 112.578 115.230 130.028 1.00 36.90 ? 288 TYR A CB  1 
ATOM 1830 C CG  . TYR A 1 245 ? 113.163 116.481 130.636 1.00 30.04 ? 288 TYR A CG  1 
ATOM 1831 C CD1 . TYR A 1 245 ? 113.297 116.612 132.008 1.00 38.87 ? 288 TYR A CD1 1 
ATOM 1832 C CD2 . TYR A 1 245 ? 113.588 117.528 129.835 1.00 36.99 ? 288 TYR A CD2 1 
ATOM 1833 C CE1 . TYR A 1 245 ? 113.836 117.752 132.566 1.00 43.42 ? 288 TYR A CE1 1 
ATOM 1834 C CE2 . TYR A 1 245 ? 114.125 118.673 130.383 1.00 37.76 ? 288 TYR A CE2 1 
ATOM 1835 C CZ  . TYR A 1 245 ? 114.248 118.779 131.749 1.00 42.25 ? 288 TYR A CZ  1 
ATOM 1836 O OH  . TYR A 1 245 ? 114.787 119.916 132.299 1.00 40.12 ? 288 TYR A OH  1 
ATOM 1837 N N   . LYS A 1 246 ? 110.145 116.543 128.509 1.00 46.82 ? 289 LYS A N   1 
ATOM 1838 C CA  . LYS A 1 246 ? 109.415 117.717 128.040 1.00 38.74 ? 289 LYS A CA  1 
ATOM 1839 C C   . LYS A 1 246 ? 107.977 117.708 128.542 1.00 33.33 ? 289 LYS A C   1 
ATOM 1840 O O   . LYS A 1 246 ? 107.461 118.737 128.998 1.00 45.47 ? 289 LYS A O   1 
ATOM 1841 C CB  . LYS A 1 246 ? 109.452 117.781 126.514 1.00 38.59 ? 289 LYS A CB  1 
ATOM 1842 C CG  . LYS A 1 246 ? 108.361 118.639 125.902 1.00 41.00 ? 289 LYS A CG  1 
ATOM 1843 C CD  . LYS A 1 246 ? 107.919 118.090 124.559 1.00 37.95 ? 289 LYS A CD  1 
ATOM 1844 C CE  . LYS A 1 246 ? 107.141 119.123 123.770 1.00 36.25 ? 289 LYS A CE  1 
ATOM 1845 N NZ  . LYS A 1 246 ? 105.691 119.099 124.100 1.00 37.91 ? 289 LYS A NZ  1 
ATOM 1846 N N   . ASN A 1 247 ? 107.320 116.548 128.483 1.00 25.66 ? 290 ASN A N   1 
ATOM 1847 C CA  . ASN A 1 247 ? 105.952 116.453 128.980 1.00 28.91 ? 290 ASN A CA  1 
ATOM 1848 C C   . ASN A 1 247 ? 105.889 116.730 130.476 1.00 35.55 ? 290 ASN A C   1 
ATOM 1849 O O   . ASN A 1 247 ? 104.929 117.337 130.963 1.00 46.03 ? 290 ASN A O   1 
ATOM 1850 C CB  . ASN A 1 247 ? 105.374 115.075 128.664 1.00 40.59 ? 290 ASN A CB  1 
ATOM 1851 C CG  . ASN A 1 247 ? 105.290 114.804 127.178 1.00 43.89 ? 290 ASN A CG  1 
ATOM 1852 O OD1 . ASN A 1 247 ? 105.390 115.719 126.362 1.00 46.73 ? 290 ASN A OD1 1 
ATOM 1853 N ND2 . ASN A 1 247 ? 105.103 113.541 126.817 1.00 41.41 ? 290 ASN A ND2 1 
ATOM 1854 N N   . ALA A 1 248 ? 106.900 116.285 131.223 1.00 36.31 ? 291 ALA A N   1 
ATOM 1855 C CA  . ALA A 1 248 ? 106.921 116.526 132.660 1.00 39.80 ? 291 ALA A CA  1 
ATOM 1856 C C   . ALA A 1 248 ? 107.124 118.003 132.969 1.00 39.40 ? 291 ALA A C   1 
ATOM 1857 O O   . ALA A 1 248 ? 106.422 118.572 133.813 1.00 48.71 ? 291 ALA A O   1 
ATOM 1858 C CB  . ALA A 1 248 ? 108.014 115.683 133.317 1.00 42.62 ? 291 ALA A CB  1 
ATOM 1859 N N   . MET A 1 249 ? 108.078 118.645 132.295 1.00 41.46 ? 292 MET A N   1 
ATOM 1860 C CA  . MET A 1 249 ? 108.345 120.052 132.560 1.00 39.74 ? 292 MET A CA  1 
ATOM 1861 C C   . MET A 1 249 ? 107.300 120.979 131.960 1.00 40.87 ? 292 MET A C   1 
ATOM 1862 O O   . MET A 1 249 ? 107.323 122.178 132.255 1.00 47.53 ? 292 MET A O   1 
ATOM 1863 C CB  . MET A 1 249 ? 109.730 120.454 132.055 1.00 37.48 ? 292 MET A CB  1 
ATOM 1864 C CG  . MET A 1 249 ? 110.841 120.114 133.026 1.00 47.65 ? 292 MET A CG  1 
ATOM 1865 S SD  . MET A 1 249 ? 111.505 121.583 133.830 1.00 68.06 ? 292 MET A SD  1 
ATOM 1866 C CE  . MET A 1 249 ? 112.624 122.194 132.582 1.00 49.92 ? 292 MET A CE  1 
ATOM 1867 N N   . ASP A 1 250 ? 106.397 120.465 131.124 1.00 40.82 ? 293 ASP A N   1 
ATOM 1868 C CA  . ASP A 1 250 ? 105.237 121.258 130.737 1.00 41.67 ? 293 ASP A CA  1 
ATOM 1869 C C   . ASP A 1 250 ? 104.367 121.620 131.934 1.00 41.16 ? 293 ASP A C   1 
ATOM 1870 O O   . ASP A 1 250 ? 103.565 122.554 131.844 1.00 45.79 ? 293 ASP A O   1 
ATOM 1871 C CB  . ASP A 1 250 ? 104.402 120.508 129.699 1.00 48.00 ? 293 ASP A CB  1 
ATOM 1872 C CG  . ASP A 1 250 ? 104.531 121.097 128.310 1.00 53.12 ? 293 ASP A CG  1 
ATOM 1873 O OD1 . ASP A 1 250 ? 105.403 121.968 128.109 1.00 56.32 ? 293 ASP A OD1 1 
ATOM 1874 O OD2 . ASP A 1 250 ? 103.759 120.691 127.417 1.00 53.26 ? 293 ASP A OD2 1 
ATOM 1875 N N   . HIS A 1 251 ? 104.505 120.902 133.048 1.00 41.72 ? 294 HIS A N   1 
ATOM 1876 C CA  . HIS A 1 251 ? 103.729 121.163 134.252 1.00 41.26 ? 294 HIS A CA  1 
ATOM 1877 C C   . HIS A 1 251 ? 104.357 122.214 135.158 1.00 44.14 ? 294 HIS A C   1 
ATOM 1878 O O   . HIS A 1 251 ? 103.726 122.614 136.141 1.00 45.05 ? 294 HIS A O   1 
ATOM 1879 C CB  . HIS A 1 251 ? 103.540 119.867 135.044 1.00 38.57 ? 294 HIS A CB  1 
ATOM 1880 C CG  . HIS A 1 251 ? 102.498 118.958 134.476 1.00 43.27 ? 294 HIS A CG  1 
ATOM 1881 N ND1 . HIS A 1 251 ? 101.225 118.869 134.995 1.00 47.59 ? 294 HIS A ND1 1 
ATOM 1882 C CD2 . HIS A 1 251 ? 102.539 118.095 133.433 1.00 47.37 ? 294 HIS A CD2 1 
ATOM 1883 C CE1 . HIS A 1 251 ? 100.526 117.992 134.297 1.00 45.08 ? 294 HIS A CE1 1 
ATOM 1884 N NE2 . HIS A 1 251 ? 101.301 117.508 133.344 1.00 46.12 ? 294 HIS A NE2 1 
ATOM 1885 N N   . LEU A 1 252 ? 105.575 122.663 134.861 1.00 45.06 ? 295 LEU A N   1 
ATOM 1886 C CA  . LEU A 1 252 ? 106.254 123.674 135.661 1.00 38.65 ? 295 LEU A CA  1 
ATOM 1887 C C   . LEU A 1 252 ? 106.245 125.046 135.002 1.00 45.32 ? 295 LEU A C   1 
ATOM 1888 O O   . LEU A 1 252 ? 106.941 125.953 135.470 1.00 49.63 ? 295 LEU A O   1 
ATOM 1889 C CB  . LEU A 1 252 ? 107.693 123.244 135.951 1.00 41.58 ? 295 LEU A CB  1 
ATOM 1890 C CG  . LEU A 1 252 ? 107.909 122.355 137.177 1.00 44.98 ? 295 LEU A CG  1 
ATOM 1891 C CD1 . LEU A 1 252 ? 109.368 122.366 137.590 1.00 43.83 ? 295 LEU A CD1 1 
ATOM 1892 C CD2 . LEU A 1 252 ? 107.023 122.800 138.328 1.00 47.98 ? 295 LEU A CD2 1 
ATOM 1893 N N   . GLY A 1 253 ? 105.480 125.222 133.927 1.00 48.65 ? 296 GLY A N   1 
ATOM 1894 C CA  . GLY A 1 253 ? 105.360 126.499 133.261 1.00 44.27 ? 296 GLY A CA  1 
ATOM 1895 C C   . GLY A 1 253 ? 106.195 126.652 132.009 1.00 42.36 ? 296 GLY A C   1 
ATOM 1896 O O   . GLY A 1 253 ? 106.015 127.638 131.284 1.00 50.25 ? 296 GLY A O   1 
ATOM 1897 N N   . VAL A 1 254 ? 107.100 125.717 131.732 1.00 34.88 ? 297 VAL A N   1 
ATOM 1898 C CA  . VAL A 1 254 ? 107.933 125.769 130.536 1.00 34.15 ? 297 VAL A CA  1 
ATOM 1899 C C   . VAL A 1 254 ? 107.164 125.056 129.429 1.00 39.01 ? 297 VAL A C   1 
ATOM 1900 O O   . VAL A 1 254 ? 107.122 123.826 129.375 1.00 43.45 ? 297 VAL A O   1 
ATOM 1901 C CB  . VAL A 1 254 ? 109.309 125.144 130.774 1.00 41.36 ? 297 VAL A CB  1 
ATOM 1902 C CG1 . VAL A 1 254 ? 110.084 125.050 129.473 1.00 41.00 ? 297 VAL A CG1 1 
ATOM 1903 C CG2 . VAL A 1 254 ? 110.085 125.952 131.801 1.00 44.27 ? 297 VAL A CG2 1 
ATOM 1904 N N   . ILE A 1 255 ? 106.547 125.835 128.544 1.00 40.70 ? 298 ILE A N   1 
ATOM 1905 C CA  . ILE A 1 255 ? 105.710 125.315 127.470 1.00 37.15 ? 298 ILE A CA  1 
ATOM 1906 C C   . ILE A 1 255 ? 106.327 125.721 126.140 1.00 36.19 ? 298 ILE A C   1 
ATOM 1907 O O   . ILE A 1 255 ? 106.661 126.893 125.936 1.00 43.96 ? 298 ILE A O   1 
ATOM 1908 C CB  . ILE A 1 255 ? 104.261 125.825 127.578 1.00 37.77 ? 298 ILE A CB  1 
ATOM 1909 C CG1 . ILE A 1 255 ? 103.779 125.759 129.026 1.00 38.94 ? 298 ILE A CG1 1 
ATOM 1910 C CG2 . ILE A 1 255 ? 103.345 125.012 126.680 1.00 42.08 ? 298 ILE A CG2 1 
ATOM 1911 C CD1 . ILE A 1 255 ? 102.418 126.373 129.243 1.00 40.67 ? 298 ILE A CD1 1 
ATOM 1912 N N   . MET A 1 256 ? 106.478 124.755 125.248 1.00 38.36 ? 299 MET A N   1 
ATOM 1913 C CA  . MET A 1 256 ? 107.081 124.940 123.940 1.00 35.43 ? 299 MET A CA  1 
ATOM 1914 C C   . MET A 1 256 ? 106.032 125.385 122.929 1.00 47.94 ? 299 MET A C   1 
ATOM 1915 O O   . MET A 1 256 ? 104.831 125.192 123.141 1.00 52.30 ? 299 MET A O   1 
ATOM 1916 C CB  . MET A 1 256 ? 107.741 123.639 123.492 1.00 43.56 ? 299 MET A CB  1 
ATOM 1917 C CG  . MET A 1 256 ? 108.792 123.132 124.467 1.00 48.84 ? 299 MET A CG  1 
ATOM 1918 S SD  . MET A 1 256 ? 110.383 123.957 124.297 1.00 61.63 ? 299 MET A SD  1 
ATOM 1919 C CE  . MET A 1 256 ? 110.445 124.896 125.815 1.00 47.47 ? 299 MET A CE  1 
ATOM 1920 N N   . PRO A 1 257 ? 106.452 126.006 121.824 1.00 43.92 ? 300 PRO A N   1 
ATOM 1921 C CA  . PRO A 1 257 ? 105.478 126.513 120.849 1.00 36.76 ? 300 PRO A CA  1 
ATOM 1922 C C   . PRO A 1 257 ? 104.590 125.411 120.287 1.00 41.43 ? 300 PRO A C   1 
ATOM 1923 O O   . PRO A 1 257 ? 105.042 124.297 120.016 1.00 52.34 ? 300 PRO A O   1 
ATOM 1924 C CB  . PRO A 1 257 ? 106.360 127.129 119.759 1.00 35.30 ? 300 PRO A CB  1 
ATOM 1925 C CG  . PRO A 1 257 ? 107.611 127.495 120.460 1.00 42.75 ? 300 PRO A CG  1 
ATOM 1926 C CD  . PRO A 1 257 ? 107.823 126.435 121.499 1.00 36.93 ? 300 PRO A CD  1 
ATOM 1927 N N   . ALA A 1 258 ? 103.311 125.743 120.110 1.00 50.04 ? 301 ALA A N   1 
ATOM 1928 C CA  . ALA A 1 258 ? 102.315 124.836 119.565 1.00 52.87 ? 301 ALA A CA  1 
ATOM 1929 C C   . ALA A 1 258 ? 102.454 124.737 118.046 1.00 58.36 ? 301 ALA A C   1 
ATOM 1930 O O   . ALA A 1 258 ? 102.926 125.676 117.399 1.00 64.21 ? 301 ALA A O   1 
ATOM 1931 C CB  . ALA A 1 258 ? 100.913 125.313 119.930 1.00 53.62 ? 301 ALA A CB  1 
ATOM 1932 N N   . PRO A 1 259 ? 102.053 123.608 117.450 1.00 52.81 ? 302 PRO A N   1 
ATOM 1933 C CA  . PRO A 1 259 ? 102.184 123.473 115.989 1.00 48.22 ? 302 PRO A CA  1 
ATOM 1934 C C   . PRO A 1 259 ? 101.298 124.424 115.204 1.00 51.04 ? 302 PRO A C   1 
ATOM 1935 O O   . PRO A 1 259 ? 101.591 124.685 114.031 1.00 55.33 ? 302 PRO A O   1 
ATOM 1936 C CB  . PRO A 1 259 ? 101.803 122.009 115.721 1.00 50.90 ? 302 PRO A CB  1 
ATOM 1937 C CG  . PRO A 1 259 ? 101.540 121.380 117.049 1.00 50.90 ? 302 PRO A CG  1 
ATOM 1938 C CD  . PRO A 1 259 ? 101.376 122.454 118.063 1.00 52.05 ? 302 PRO A CD  1 
ATOM 1939 N N   . GLY A 1 260 ? 100.233 124.948 115.802 1.00 55.73 ? 303 GLY A N   1 
ATOM 1940 C CA  . GLY A 1 260 ? 99.345  125.864 115.122 1.00 54.47 ? 303 GLY A CA  1 
ATOM 1941 C C   . GLY A 1 260 ? 99.733  127.321 115.182 1.00 56.15 ? 303 GLY A C   1 
ATOM 1942 O O   . GLY A 1 260 ? 99.002  128.168 114.658 1.00 55.81 ? 303 GLY A O   1 
ATOM 1943 N N   . ASP A 1 261 ? 100.866 127.650 115.804 1.00 58.64 ? 304 ASP A N   1 
ATOM 1944 C CA  . ASP A 1 261 ? 101.312 129.032 115.929 1.00 57.72 ? 304 ASP A CA  1 
ATOM 1945 C C   . ASP A 1 261 ? 102.700 129.257 115.344 1.00 57.89 ? 304 ASP A C   1 
ATOM 1946 O O   . ASP A 1 261 ? 103.285 130.324 115.560 1.00 64.11 ? 304 ASP A O   1 
ATOM 1947 C CB  . ASP A 1 261 ? 101.287 129.468 117.396 1.00 60.88 ? 304 ASP A CB  1 
ATOM 1948 C CG  . ASP A 1 261 ? 99.957  129.185 118.065 1.00 64.90 ? 304 ASP A CG  1 
ATOM 1949 O OD1 . ASP A 1 261 ? 98.965  129.865 117.729 1.00 65.32 ? 304 ASP A OD1 1 
ATOM 1950 O OD2 . ASP A 1 261 ? 99.902  128.283 118.926 1.00 66.62 ? 304 ASP A OD2 1 
ATOM 1951 N N   . ILE A 1 262 ? 103.243 128.287 114.616 1.00 44.15 ? 305 ILE A N   1 
ATOM 1952 C CA  . ILE A 1 262 ? 104.542 128.440 113.967 1.00 41.87 ? 305 ILE A CA  1 
ATOM 1953 C C   . ILE A 1 262 ? 104.325 129.068 112.595 1.00 47.23 ? 305 ILE A C   1 
ATOM 1954 O O   . ILE A 1 262 ? 103.532 128.548 111.797 1.00 58.28 ? 305 ILE A O   1 
ATOM 1955 C CB  . ILE A 1 262 ? 105.278 127.097 113.862 1.00 46.06 ? 305 ILE A CB  1 
ATOM 1956 C CG1 . ILE A 1 262 ? 105.251 126.371 115.206 1.00 47.23 ? 305 ILE A CG1 1 
ATOM 1957 C CG2 . ILE A 1 262 ? 106.711 127.310 113.407 1.00 49.14 ? 305 ILE A CG2 1 
ATOM 1958 C CD1 . ILE A 1 262 ? 105.511 124.886 115.105 1.00 49.60 ? 305 ILE A CD1 1 
ATOM 1959 N N   . PRO A 1 263 ? 104.986 130.181 112.285 1.00 35.87 ? 306 PRO A N   1 
ATOM 1960 C CA  . PRO A 1 263 ? 104.767 130.833 110.988 1.00 37.37 ? 306 PRO A CA  1 
ATOM 1961 C C   . PRO A 1 263 ? 105.187 129.940 109.831 1.00 43.38 ? 306 PRO A C   1 
ATOM 1962 O O   . PRO A 1 263 ? 106.103 129.122 109.945 1.00 50.52 ? 306 PRO A O   1 
ATOM 1963 C CB  . PRO A 1 263 ? 105.634 132.096 111.058 1.00 43.49 ? 306 PRO A CB  1 
ATOM 1964 C CG  . PRO A 1 263 ? 106.145 132.194 112.444 1.00 47.86 ? 306 PRO A CG  1 
ATOM 1965 C CD  . PRO A 1 263 ? 105.938 130.901 113.145 1.00 44.30 ? 306 PRO A CD  1 
ATOM 1966 N N   . ASP A 1 264 ? 104.496 130.106 108.702 1.00 39.08 ? 307 ASP A N   1 
ATOM 1967 C CA  . ASP A 1 264 ? 104.771 129.310 107.514 1.00 36.29 ? 307 ASP A CA  1 
ATOM 1968 C C   . ASP A 1 264 ? 106.113 129.637 106.876 1.00 41.00 ? 307 ASP A C   1 
ATOM 1969 O O   . ASP A 1 264 ? 106.589 128.856 106.046 1.00 46.73 ? 307 ASP A O   1 
ATOM 1970 C CB  . ASP A 1 264 ? 103.655 129.501 106.486 1.00 44.32 ? 307 ASP A CB  1 
ATOM 1971 C CG  . ASP A 1 264 ? 102.284 129.200 107.055 1.00 52.45 ? 307 ASP A CG  1 
ATOM 1972 O OD1 . ASP A 1 264 ? 102.049 128.044 107.464 1.00 49.99 ? 307 ASP A OD1 1 
ATOM 1973 O OD2 . ASP A 1 264 ? 101.439 130.119 107.093 1.00 54.46 ? 307 ASP A OD2 1 
ATOM 1974 N N   . SER A 1 265 ? 106.731 130.762 107.235 1.00 40.39 ? 308 SER A N   1 
ATOM 1975 C CA  . SER A 1 265 ? 108.035 131.119 106.692 1.00 39.23 ? 308 SER A CA  1 
ATOM 1976 C C   . SER A 1 265 ? 109.180 130.371 107.359 1.00 39.63 ? 308 SER A C   1 
ATOM 1977 O O   . SER A 1 265 ? 110.320 130.483 106.899 1.00 40.96 ? 308 SER A O   1 
ATOM 1978 C CB  . SER A 1 265 ? 108.264 132.625 106.823 1.00 45.90 ? 308 SER A CB  1 
ATOM 1979 O OG  . SER A 1 265 ? 109.544 132.987 106.337 1.00 48.34 ? 308 SER A OG  1 
ATOM 1980 N N   . SER A 1 266 ? 108.908 129.622 108.429 1.00 47.91 ? 309 SER A N   1 
ATOM 1981 C CA  . SER A 1 266 ? 109.965 128.865 109.091 1.00 48.52 ? 309 SER A CA  1 
ATOM 1982 C C   . SER A 1 266 ? 110.394 127.664 108.257 1.00 56.25 ? 309 SER A C   1 
ATOM 1983 O O   . SER A 1 266 ? 111.580 127.316 108.224 1.00 60.13 ? 309 SER A O   1 
ATOM 1984 C CB  . SER A 1 266 ? 109.498 128.417 110.474 1.00 47.95 ? 309 SER A CB  1 
ATOM 1985 O OG  . SER A 1 266 ? 108.833 129.469 111.151 1.00 48.24 ? 309 SER A OG  1 
ATOM 1986 N N   . TYR A 1 267 ? 109.446 127.019 107.577 1.00 48.36 ? 310 TYR A N   1 
ATOM 1987 C CA  . TYR A 1 267 ? 109.739 125.826 106.795 1.00 45.74 ? 310 TYR A CA  1 
ATOM 1988 C C   . TYR A 1 267 ? 110.383 126.130 105.449 1.00 45.47 ? 310 TYR A C   1 
ATOM 1989 O O   . TYR A 1 267 ? 110.857 125.201 104.788 1.00 55.69 ? 310 TYR A O   1 
ATOM 1990 C CB  . TYR A 1 267 ? 108.460 125.020 106.565 1.00 42.61 ? 310 TYR A CB  1 
ATOM 1991 C CG  . TYR A 1 267 ? 107.686 124.700 107.821 1.00 37.62 ? 310 TYR A CG  1 
ATOM 1992 C CD1 . TYR A 1 267 ? 108.001 123.589 108.589 1.00 40.58 ? 310 TYR A CD1 1 
ATOM 1993 C CD2 . TYR A 1 267 ? 106.629 125.498 108.229 1.00 38.40 ? 310 TYR A CD2 1 
ATOM 1994 C CE1 . TYR A 1 267 ? 107.291 123.288 109.733 1.00 40.89 ? 310 TYR A CE1 1 
ATOM 1995 C CE2 . TYR A 1 267 ? 105.914 125.205 109.371 1.00 43.06 ? 310 TYR A CE2 1 
ATOM 1996 C CZ  . TYR A 1 267 ? 106.250 124.099 110.119 1.00 42.51 ? 310 TYR A CZ  1 
ATOM 1997 O OH  . TYR A 1 267 ? 105.541 123.803 111.259 1.00 45.22 ? 310 TYR A OH  1 
ATOM 1998 N N   . ASP A 1 268 ? 110.410 127.390 105.029 1.00 34.36 ? 311 ASP A N   1 
ATOM 1999 C CA  . ASP A 1 268 ? 110.919 127.730 103.709 1.00 35.06 ? 311 ASP A CA  1 
ATOM 2000 C C   . ASP A 1 268 ? 112.424 127.498 103.626 1.00 43.13 ? 311 ASP A C   1 
ATOM 2001 O O   . ASP A 1 268 ? 113.159 127.665 104.602 1.00 51.67 ? 311 ASP A O   1 
ATOM 2002 C CB  . ASP A 1 268 ? 110.595 129.184 103.372 1.00 45.18 ? 311 ASP A CB  1 
ATOM 2003 C CG  . ASP A 1 268 ? 109.183 129.359 102.851 1.00 52.40 ? 311 ASP A CG  1 
ATOM 2004 O OD1 . ASP A 1 268 ? 108.426 128.366 102.837 1.00 54.04 ? 311 ASP A OD1 1 
ATOM 2005 O OD2 . ASP A 1 268 ? 108.830 130.490 102.455 1.00 54.38 ? 311 ASP A OD2 1 
ATOM 2006 N N   . LEU A 1 269 ? 112.876 127.102 102.439 1.00 39.33 ? 312 LEU A N   1 
ATOM 2007 C CA  . LEU A 1 269 ? 114.296 126.884 102.208 1.00 40.21 ? 312 LEU A CA  1 
ATOM 2008 C C   . LEU A 1 269 ? 115.058 128.198 102.315 1.00 45.62 ? 312 LEU A C   1 
ATOM 2009 O O   . LEU A 1 269 ? 114.561 129.257 101.924 1.00 51.37 ? 312 LEU A O   1 
ATOM 2010 C CB  . LEU A 1 269 ? 114.519 126.253 100.835 1.00 46.51 ? 312 LEU A CB  1 
ATOM 2011 C CG  . LEU A 1 269 ? 113.698 124.997 100.539 1.00 46.75 ? 312 LEU A CG  1 
ATOM 2012 C CD1 . LEU A 1 269 ? 113.900 124.545 99.105  1.00 45.11 ? 312 LEU A CD1 1 
ATOM 2013 C CD2 . LEU A 1 269 ? 114.052 123.883 101.510 1.00 48.33 ? 312 LEU A CD2 1 
ATOM 2014 N N   . ARG A 1 270 ? 116.276 128.123 102.843 1.00 36.79 ? 313 ARG A N   1 
ATOM 2015 C CA  . ARG A 1 270 ? 117.065 129.303 103.154 1.00 35.93 ? 313 ARG A CA  1 
ATOM 2016 C C   . ARG A 1 270 ? 118.420 129.219 102.469 1.00 36.22 ? 313 ARG A C   1 
ATOM 2017 O O   . ARG A 1 270 ? 118.934 128.130 102.200 1.00 41.99 ? 313 ARG A O   1 
ATOM 2018 C CB  . ARG A 1 270 ? 117.253 129.454 104.670 1.00 43.47 ? 313 ARG A CB  1 
ATOM 2019 C CG  . ARG A 1 270 ? 117.877 130.763 105.112 1.00 40.60 ? 313 ARG A CG  1 
ATOM 2020 C CD  . ARG A 1 270 ? 117.554 131.047 106.561 1.00 39.62 ? 313 ARG A CD  1 
ATOM 2021 N NE  . ARG A 1 270 ? 118.165 130.072 107.455 1.00 40.59 ? 313 ARG A NE  1 
ATOM 2022 C CZ  . ARG A 1 270 ? 117.487 129.200 108.187 1.00 43.24 ? 313 ARG A CZ  1 
ATOM 2023 N NH1 . ARG A 1 270 ? 116.167 129.141 108.144 1.00 44.16 ? 313 ARG A NH1 1 
ATOM 2024 N NH2 . ARG A 1 270 ? 118.150 128.365 108.980 1.00 44.82 ? 313 ARG A NH2 1 
ATOM 2025 N N   . TRP A 1 271 ? 118.992 130.387 102.185 1.00 43.73 ? 314 TRP A N   1 
ATOM 2026 C CA  . TRP A 1 271 ? 120.317 130.495 101.590 1.00 45.97 ? 314 TRP A CA  1 
ATOM 2027 C C   . TRP A 1 271 ? 121.129 131.513 102.377 1.00 55.67 ? 314 TRP A C   1 
ATOM 2028 O O   . TRP A 1 271 ? 120.774 132.696 102.418 1.00 55.57 ? 314 TRP A O   1 
ATOM 2029 C CB  . TRP A 1 271 ? 120.225 130.897 100.117 1.00 36.02 ? 314 TRP A CB  1 
ATOM 2030 C CG  . TRP A 1 271 ? 121.549 130.965 99.447  1.00 40.54 ? 314 TRP A CG  1 
ATOM 2031 C CD1 . TRP A 1 271 ? 122.261 129.924 98.934  1.00 48.92 ? 314 TRP A CD1 1 
ATOM 2032 C CD2 . TRP A 1 271 ? 122.328 132.140 99.210  1.00 43.50 ? 314 TRP A CD2 1 
ATOM 2033 N NE1 . TRP A 1 271 ? 123.438 130.377 98.394  1.00 50.76 ? 314 TRP A NE1 1 
ATOM 2034 C CE2 . TRP A 1 271 ? 123.503 131.736 98.551  1.00 46.93 ? 314 TRP A CE2 1 
ATOM 2035 C CE3 . TRP A 1 271 ? 122.146 133.497 99.492  1.00 45.56 ? 314 TRP A CE3 1 
ATOM 2036 C CZ2 . TRP A 1 271 ? 124.490 132.637 98.169  1.00 48.42 ? 314 TRP A CZ2 1 
ATOM 2037 C CZ3 . TRP A 1 271 ? 123.128 134.388 99.114  1.00 47.17 ? 314 TRP A CZ3 1 
ATOM 2038 C CH2 . TRP A 1 271 ? 124.284 133.956 98.460  1.00 47.10 ? 314 TRP A CH2 1 
ATOM 2039 N N   . GLU A 1 272 ? 122.212 131.054 102.998 1.00 52.57 ? 315 GLU A N   1 
ATOM 2040 C CA  . GLU A 1 272 ? 123.087 131.932 103.758 1.00 33.30 ? 315 GLU A CA  1 
ATOM 2041 C C   . GLU A 1 272 ? 123.938 132.782 102.820 1.00 35.70 ? 315 GLU A C   1 
ATOM 2042 O O   . GLU A 1 272 ? 124.103 132.477 101.637 1.00 56.90 ? 315 GLU A O   1 
ATOM 2043 C CB  . GLU A 1 272 ? 123.995 131.120 104.680 1.00 50.03 ? 315 GLU A CB  1 
ATOM 2044 C CG  . GLU A 1 272 ? 123.268 130.216 105.663 1.00 52.37 ? 315 GLU A CG  1 
ATOM 2045 C CD  . GLU A 1 272 ? 122.655 130.976 106.820 1.00 60.41 ? 315 GLU A CD  1 
ATOM 2046 O OE1 . GLU A 1 272 ? 123.324 131.884 107.357 1.00 60.13 ? 315 GLU A OE1 1 
ATOM 2047 O OE2 . GLU A 1 272 ? 121.508 130.662 107.200 1.00 60.02 ? 315 GLU A OE2 1 
ATOM 2048 N N   . SER A 1 273 ? 124.498 133.855 103.370 1.00 33.38 ? 316 SER A N   1 
ATOM 2049 C CA  . SER A 1 273 ? 125.360 134.766 102.619 1.00 45.72 ? 316 SER A CA  1 
ATOM 2050 C C   . SER A 1 273 ? 126.837 134.501 102.884 1.00 53.56 ? 316 SER A C   1 
ATOM 2051 O O   . SER A 1 273 ? 127.652 135.426 102.885 1.00 52.18 ? 316 SER A O   1 
ATOM 2052 C CB  . SER A 1 273 ? 125.008 136.213 102.944 1.00 50.11 ? 316 SER A CB  1 
ATOM 2053 O OG  . SER A 1 273 ? 125.584 137.101 102.002 1.00 56.33 ? 316 SER A OG  1 
ATOM 2054 N N   . TRP A 1 274 ? 127.208 133.241 103.107 1.00 60.58 ? 317 TRP A N   1 
ATOM 2055 C CA  . TRP A 1 274 ? 128.590 132.879 103.389 1.00 51.31 ? 317 TRP A CA  1 
ATOM 2056 C C   . TRP A 1 274 ? 129.396 132.563 102.137 1.00 53.83 ? 317 TRP A C   1 
ATOM 2057 O O   . TRP A 1 274 ? 130.557 132.161 102.257 1.00 57.54 ? 317 TRP A O   1 
ATOM 2058 C CB  . TRP A 1 274 ? 128.647 131.663 104.322 1.00 54.61 ? 317 TRP A CB  1 
ATOM 2059 C CG  . TRP A 1 274 ? 128.965 131.972 105.760 1.00 58.59 ? 317 TRP A CG  1 
ATOM 2060 C CD1 . TRP A 1 274 ? 128.332 131.465 106.855 1.00 60.11 ? 317 TRP A CD1 1 
ATOM 2061 C CD2 . TRP A 1 274 ? 129.986 132.850 106.259 1.00 62.78 ? 317 TRP A CD2 1 
ATOM 2062 N NE1 . TRP A 1 274 ? 128.890 131.969 108.003 1.00 61.65 ? 317 TRP A NE1 1 
ATOM 2063 C CE2 . TRP A 1 274 ? 129.908 132.822 107.665 1.00 62.37 ? 317 TRP A CE2 1 
ATOM 2064 C CE3 . TRP A 1 274 ? 130.958 133.655 105.656 1.00 61.93 ? 317 TRP A CE3 1 
ATOM 2065 C CZ2 . TRP A 1 274 ? 130.761 133.566 108.475 1.00 58.81 ? 317 TRP A CZ2 1 
ATOM 2066 C CZ3 . TRP A 1 274 ? 131.802 134.394 106.462 1.00 59.10 ? 317 TRP A CZ3 1 
ATOM 2067 C CH2 . TRP A 1 274 ? 131.699 134.344 107.856 1.00 57.60 ? 317 TRP A CH2 1 
ATOM 2068 N N   . GLY A 1 275 ? 128.812 132.721 100.952 1.00 61.90 ? 318 GLY A N   1 
ATOM 2069 C CA  . GLY A 1 275 ? 129.457 132.316 99.719  1.00 60.76 ? 318 GLY A CA  1 
ATOM 2070 C C   . GLY A 1 275 ? 130.804 132.961 99.471  1.00 60.18 ? 318 GLY A C   1 
ATOM 2071 O O   . GLY A 1 275 ? 131.760 132.283 99.081  1.00 64.85 ? 318 GLY A O   1 
ATOM 2072 N N   . TRP A 1 276 ? 130.896 134.268 99.693  1.00 55.98 ? 319 TRP A N   1 
ATOM 2073 C CA  . TRP A 1 276 ? 132.135 135.005 99.495  1.00 56.78 ? 319 TRP A CA  1 
ATOM 2074 C C   . TRP A 1 276 ? 132.849 135.329 100.800 1.00 63.16 ? 319 TRP A C   1 
ATOM 2075 O O   . TRP A 1 276 ? 133.878 136.011 100.774 1.00 65.09 ? 319 TRP A O   1 
ATOM 2076 C CB  . TRP A 1 276 ? 131.863 136.297 98.720  1.00 56.50 ? 319 TRP A CB  1 
ATOM 2077 C CG  . TRP A 1 276 ? 130.873 136.141 97.607  1.00 56.88 ? 319 TRP A CG  1 
ATOM 2078 C CD1 . TRP A 1 276 ? 131.150 136.008 96.280  1.00 59.40 ? 319 TRP A CD1 1 
ATOM 2079 C CD2 . TRP A 1 276 ? 129.444 136.122 97.722  1.00 59.35 ? 319 TRP A CD2 1 
ATOM 2080 N NE1 . TRP A 1 276 ? 129.985 135.897 95.561  1.00 61.07 ? 319 TRP A NE1 1 
ATOM 2081 C CE2 . TRP A 1 276 ? 128.924 135.966 96.424  1.00 59.54 ? 319 TRP A CE2 1 
ATOM 2082 C CE3 . TRP A 1 276 ? 128.556 136.219 98.797  1.00 63.63 ? 319 TRP A CE3 1 
ATOM 2083 C CZ2 . TRP A 1 276 ? 127.557 135.903 96.171  1.00 59.57 ? 319 TRP A CZ2 1 
ATOM 2084 C CZ3 . TRP A 1 276 ? 127.200 136.155 98.543  1.00 60.21 ? 319 TRP A CZ3 1 
ATOM 2085 C CH2 . TRP A 1 276 ? 126.714 136.000 97.242  1.00 59.51 ? 319 TRP A CH2 1 
ATOM 2086 N N   . GLY A 1 277 ? 132.335 134.864 101.931 1.00 65.41 ? 320 GLY A N   1 
ATOM 2087 C CA  . GLY A 1 277 ? 133.005 135.107 103.199 1.00 61.65 ? 320 GLY A CA  1 
ATOM 2088 C C   . GLY A 1 277 ? 132.632 136.458 103.763 1.00 65.39 ? 320 GLY A C   1 
ATOM 2089 O O   . GLY A 1 277 ? 131.453 136.813 103.831 1.00 66.19 ? 320 GLY A O   1 
ATOM 2090 N N   . PHE A 1 278 ? 133.642 137.218 104.176 1.00 60.25 ? 321 PHE A N   1 
ATOM 2091 C CA  . PHE A 1 278 ? 133.450 138.556 104.718 1.00 51.51 ? 321 PHE A CA  1 
ATOM 2092 C C   . PHE A 1 278 ? 133.481 139.638 103.649 1.00 51.26 ? 321 PHE A C   1 
ATOM 2093 O O   . PHE A 1 278 ? 133.349 140.820 103.981 1.00 60.42 ? 321 PHE A O   1 
ATOM 2094 C CB  . PHE A 1 278 ? 134.521 138.858 105.772 1.00 55.04 ? 321 PHE A CB  1 
ATOM 2095 C CG  . PHE A 1 278 ? 134.135 138.453 107.164 1.00 58.59 ? 321 PHE A CG  1 
ATOM 2096 C CD1 . PHE A 1 278 ? 133.618 139.380 108.051 1.00 53.83 ? 321 PHE A CD1 1 
ATOM 2097 C CD2 . PHE A 1 278 ? 134.296 137.146 107.588 1.00 59.44 ? 321 PHE A CD2 1 
ATOM 2098 C CE1 . PHE A 1 278 ? 133.264 139.011 109.333 1.00 53.33 ? 321 PHE A CE1 1 
ATOM 2099 C CE2 . PHE A 1 278 ? 133.944 136.771 108.869 1.00 59.43 ? 321 PHE A CE2 1 
ATOM 2100 C CZ  . PHE A 1 278 ? 133.428 137.704 109.742 1.00 56.90 ? 321 PHE A CZ  1 
ATOM 2101 N N   . ASN A 1 279 ? 133.649 139.268 102.383 1.00 48.11 ? 322 ASN A N   1 
ATOM 2102 C CA  . ASN A 1 279 ? 133.784 140.219 101.286 1.00 52.00 ? 322 ASN A CA  1 
ATOM 2103 C C   . ASN A 1 279 ? 132.523 140.273 100.429 1.00 60.83 ? 322 ASN A C   1 
ATOM 2104 O O   . ASN A 1 279 ? 132.589 140.418 99.207  1.00 62.37 ? 322 ASN A O   1 
ATOM 2105 C CB  . ASN A 1 279 ? 134.996 139.874 100.426 1.00 51.58 ? 322 ASN A CB  1 
ATOM 2106 C CG  . ASN A 1 279 ? 136.098 139.206 101.220 1.00 60.89 ? 322 ASN A CG  1 
ATOM 2107 O OD1 . ASN A 1 279 ? 136.468 139.666 102.300 1.00 63.98 ? 322 ASN A OD1 1 
ATOM 2108 N ND2 . ASN A 1 279 ? 136.630 138.111 100.689 1.00 59.24 ? 322 ASN A ND2 1 
ATOM 2109 N N   . TRP A 1 280 ? 131.359 140.158 101.061 1.00 55.66 ? 323 TRP A N   1 
ATOM 2110 C CA  . TRP A 1 280 ? 130.101 140.193 100.331 1.00 47.20 ? 323 TRP A CA  1 
ATOM 2111 C C   . TRP A 1 280 ? 129.660 141.630 100.088 1.00 49.66 ? 323 TRP A C   1 
ATOM 2112 O O   . TRP A 1 280 ? 129.992 142.545 100.847 1.00 59.91 ? 323 TRP A O   1 
ATOM 2113 C CB  . TRP A 1 280 ? 129.021 139.415 101.088 1.00 41.44 ? 323 TRP A CB  1 
ATOM 2114 C CG  . TRP A 1 280 ? 128.617 139.984 102.423 1.00 43.03 ? 323 TRP A CG  1 
ATOM 2115 C CD1 . TRP A 1 280 ? 128.930 139.474 103.648 1.00 47.97 ? 323 TRP A CD1 1 
ATOM 2116 C CD2 . TRP A 1 280 ? 127.759 141.110 102.669 1.00 50.95 ? 323 TRP A CD2 1 
ATOM 2117 N NE1 . TRP A 1 280 ? 128.365 140.236 104.639 1.00 48.03 ? 323 TRP A NE1 1 
ATOM 2118 C CE2 . TRP A 1 280 ? 127.637 141.244 104.065 1.00 47.31 ? 323 TRP A CE2 1 
ATOM 2119 C CE3 . TRP A 1 280 ? 127.097 142.027 101.846 1.00 56.62 ? 323 TRP A CE3 1 
ATOM 2120 C CZ2 . TRP A 1 280 ? 126.886 142.256 104.655 1.00 49.76 ? 323 TRP A CZ2 1 
ATOM 2121 C CZ3 . TRP A 1 280 ? 126.355 143.033 102.435 1.00 59.07 ? 323 TRP A CZ3 1 
ATOM 2122 C CH2 . TRP A 1 280 ? 126.254 143.138 103.825 1.00 54.20 ? 323 TRP A CH2 1 
ATOM 2123 N N   . THR A 1 281 ? 128.909 141.821 99.006  1.00 49.02 ? 324 THR A N   1 
ATOM 2124 C CA  . THR A 1 281 ? 128.344 143.115 98.655  1.00 48.07 ? 324 THR A CA  1 
ATOM 2125 C C   . THR A 1 281 ? 126.855 142.957 98.381  1.00 51.54 ? 324 THR A C   1 
ATOM 2126 O O   . THR A 1 281 ? 126.361 141.855 98.126  1.00 55.08 ? 324 THR A O   1 
ATOM 2127 C CB  . THR A 1 281 ? 129.033 143.733 97.429  1.00 50.65 ? 324 THR A CB  1 
ATOM 2128 O OG1 . THR A 1 281 ? 128.666 143.004 96.252  1.00 54.93 ? 324 THR A OG1 1 
ATOM 2129 C CG2 . THR A 1 281 ? 130.546 143.711 97.587  1.00 50.34 ? 324 THR A CG2 1 
ATOM 2130 N N   . ILE A 1 282 ? 126.141 144.082 98.445  1.00 44.63 ? 325 ILE A N   1 
ATOM 2131 C CA  . ILE A 1 282 ? 124.703 144.073 98.190  1.00 46.15 ? 325 ILE A CA  1 
ATOM 2132 C C   . ILE A 1 282 ? 124.417 143.657 96.752  1.00 48.43 ? 325 ILE A C   1 
ATOM 2133 O O   . ILE A 1 282 ? 123.476 142.898 96.482  1.00 54.65 ? 325 ILE A O   1 
ATOM 2134 C CB  . ILE A 1 282 ? 124.098 145.452 98.511  1.00 47.44 ? 325 ILE A CB  1 
ATOM 2135 C CG1 . ILE A 1 282 ? 124.304 145.797 99.985  1.00 50.31 ? 325 ILE A CG1 1 
ATOM 2136 C CG2 . ILE A 1 282 ? 122.620 145.488 98.158  1.00 52.30 ? 325 ILE A CG2 1 
ATOM 2137 C CD1 . ILE A 1 282 ? 123.669 147.104 100.398 1.00 47.60 ? 325 ILE A CD1 1 
ATOM 2138 N N   . ASP A 1 283 ? 125.224 144.149 95.809  1.00 47.37 ? 326 ASP A N   1 
ATOM 2139 C CA  . ASP A 1 283 ? 124.977 143.876 94.397  1.00 48.42 ? 326 ASP A CA  1 
ATOM 2140 C C   . ASP A 1 283 ? 125.086 142.389 94.087  1.00 52.02 ? 326 ASP A C   1 
ATOM 2141 O O   . ASP A 1 283 ? 124.324 141.866 93.267  1.00 55.29 ? 326 ASP A O   1 
ATOM 2142 C CB  . ASP A 1 283 ? 125.949 144.677 93.533  1.00 51.47 ? 326 ASP A CB  1 
ATOM 2143 C CG  . ASP A 1 283 ? 125.601 146.149 93.480  1.00 55.42 ? 326 ASP A CG  1 
ATOM 2144 O OD1 . ASP A 1 283 ? 124.828 146.608 94.347  1.00 54.30 ? 326 ASP A OD1 1 
ATOM 2145 O OD2 . ASP A 1 283 ? 126.099 146.848 92.573  1.00 59.05 ? 326 ASP A OD2 1 
ATOM 2146 N N   . LEU A 1 284 ? 126.030 141.693 94.721  1.00 47.56 ? 327 LEU A N   1 
ATOM 2147 C CA  . LEU A 1 284 ? 126.179 140.260 94.483  1.00 44.66 ? 327 LEU A CA  1 
ATOM 2148 C C   . LEU A 1 284 ? 124.942 139.496 94.941  1.00 44.82 ? 327 LEU A C   1 
ATOM 2149 O O   . LEU A 1 284 ? 124.426 138.630 94.222  1.00 60.22 ? 327 LEU A O   1 
ATOM 2150 C CB  . LEU A 1 284 ? 127.430 139.741 95.194  1.00 45.26 ? 327 LEU A CB  1 
ATOM 2151 C CG  . LEU A 1 284 ? 128.732 139.676 94.389  1.00 48.22 ? 327 LEU A CG  1 
ATOM 2152 C CD1 . LEU A 1 284 ? 129.045 141.003 93.717  1.00 48.22 ? 327 LEU A CD1 1 
ATOM 2153 C CD2 . LEU A 1 284 ? 129.884 139.249 95.282  1.00 47.10 ? 327 LEU A CD2 1 
ATOM 2154 N N   . ILE A 1 285 ? 124.441 139.819 96.136  1.00 30.95 ? 328 ILE A N   1 
ATOM 2155 C CA  . ILE A 1 285 ? 123.250 139.150 96.647  1.00 34.34 ? 328 ILE A CA  1 
ATOM 2156 C C   . ILE A 1 285 ? 122.050 139.461 95.766  1.00 40.38 ? 328 ILE A C   1 
ATOM 2157 O O   . ILE A 1 285 ? 121.205 138.594 95.513  1.00 47.34 ? 328 ILE A O   1 
ATOM 2158 C CB  . ILE A 1 285 ? 122.994 139.547 98.112  1.00 40.20 ? 328 ILE A CB  1 
ATOM 2159 C CG1 . ILE A 1 285 ? 124.264 139.373 98.944  1.00 42.70 ? 328 ILE A CG1 1 
ATOM 2160 C CG2 . ILE A 1 285 ? 121.864 138.721 98.699  1.00 41.91 ? 328 ILE A CG2 1 
ATOM 2161 C CD1 . ILE A 1 285 ? 124.217 140.079 100.278 1.00 44.58 ? 328 ILE A CD1 1 
ATOM 2162 N N   . ILE A 1 286 ? 121.953 140.702 95.285  1.00 45.94 ? 329 ILE A N   1 
ATOM 2163 C CA  . ILE A 1 286 ? 120.854 141.069 94.399  1.00 41.29 ? 329 ILE A CA  1 
ATOM 2164 C C   . ILE A 1 286 ? 120.936 140.290 93.091  1.00 47.16 ? 329 ILE A C   1 
ATOM 2165 O O   . ILE A 1 286 ? 119.925 139.788 92.585  1.00 53.05 ? 329 ILE A O   1 
ATOM 2166 C CB  . ILE A 1 286 ? 120.848 142.590 94.163  1.00 39.76 ? 329 ILE A CB  1 
ATOM 2167 C CG1 . ILE A 1 286 ? 120.068 143.294 95.274  1.00 39.59 ? 329 ILE A CG1 1 
ATOM 2168 C CG2 . ILE A 1 286 ? 120.256 142.930 92.804  1.00 47.05 ? 329 ILE A CG2 1 
ATOM 2169 C CD1 . ILE A 1 286 ? 120.134 144.801 95.204  1.00 46.34 ? 329 ILE A CD1 1 
ATOM 2170 N N   . GLY A 1 287 ? 122.140 140.160 92.530  1.00 42.66 ? 330 GLY A N   1 
ATOM 2171 C CA  . GLY A 1 287 ? 122.310 139.465 91.268  1.00 43.31 ? 330 GLY A CA  1 
ATOM 2172 C C   . GLY A 1 287 ? 122.210 137.959 91.367  1.00 40.20 ? 330 GLY A C   1 
ATOM 2173 O O   . GLY A 1 287 ? 122.051 137.292 90.340  1.00 46.63 ? 330 GLY A O   1 
ATOM 2174 N N   . LYS A 1 288 ? 122.301 137.405 92.574  1.00 39.08 ? 331 LYS A N   1 
ATOM 2175 C CA  . LYS A 1 288 ? 122.148 135.971 92.774  1.00 39.11 ? 331 LYS A CA  1 
ATOM 2176 C C   . LYS A 1 288 ? 120.713 135.565 93.090  1.00 41.12 ? 331 LYS A C   1 
ATOM 2177 O O   . LYS A 1 288 ? 120.460 134.386 93.354  1.00 49.07 ? 331 LYS A O   1 
ATOM 2178 C CB  . LYS A 1 288 ? 123.079 135.489 93.888  1.00 43.21 ? 331 LYS A CB  1 
ATOM 2179 C CG  . LYS A 1 288 ? 124.365 134.855 93.389  1.00 46.95 ? 331 LYS A CG  1 
ATOM 2180 C CD  . LYS A 1 288 ? 124.951 133.915 94.427  1.00 49.18 ? 331 LYS A CD  1 
ATOM 2181 C CE  . LYS A 1 288 ? 124.311 132.540 94.350  1.00 46.98 ? 331 LYS A CE  1 
ATOM 2182 N NZ  . LYS A 1 288 ? 124.955 131.685 93.316  1.00 47.64 ? 331 LYS A NZ  1 
ATOM 2183 N N   . LEU A 1 289 ? 119.769 136.508 93.070  1.00 41.42 ? 332 LEU A N   1 
ATOM 2184 C CA  . LEU A 1 289 ? 118.404 136.209 93.490  1.00 39.66 ? 332 LEU A CA  1 
ATOM 2185 C C   . LEU A 1 289 ? 117.614 135.438 92.439  1.00 44.63 ? 332 LEU A C   1 
ATOM 2186 O O   . LEU A 1 289 ? 116.751 134.630 92.797  1.00 48.22 ? 332 LEU A O   1 
ATOM 2187 C CB  . LEU A 1 289 ? 117.669 137.502 93.842  1.00 41.58 ? 332 LEU A CB  1 
ATOM 2188 C CG  . LEU A 1 289 ? 118.077 138.189 95.145  1.00 40.21 ? 332 LEU A CG  1 
ATOM 2189 C CD1 . LEU A 1 289 ? 117.353 139.515 95.301  1.00 46.18 ? 332 LEU A CD1 1 
ATOM 2190 C CD2 . LEU A 1 289 ? 117.808 137.285 96.334  1.00 41.04 ? 332 LEU A CD2 1 
ATOM 2191 N N   . ASP A 1 290 ? 117.876 135.677 91.152  1.00 51.91 ? 333 ASP A N   1 
ATOM 2192 C CA  . ASP A 1 290 ? 117.078 135.050 90.102  1.00 46.78 ? 333 ASP A CA  1 
ATOM 2193 C C   . ASP A 1 290 ? 117.255 133.535 90.094  1.00 48.57 ? 333 ASP A C   1 
ATOM 2194 O O   . ASP A 1 290 ? 116.274 132.785 90.004  1.00 54.45 ? 333 ASP A O   1 
ATOM 2195 C CB  . ASP A 1 290 ? 117.449 135.639 88.741  1.00 48.56 ? 333 ASP A CB  1 
ATOM 2196 C CG  . ASP A 1 290 ? 117.298 137.144 88.698  1.00 54.18 ? 333 ASP A CG  1 
ATOM 2197 O OD1 . ASP A 1 290 ? 117.202 137.764 89.777  1.00 55.31 ? 333 ASP A OD1 1 
ATOM 2198 O OD2 . ASP A 1 290 ? 117.277 137.708 87.584  1.00 56.87 ? 333 ASP A OD2 1 
ATOM 2199 N N   . GLU A 1 291 ? 118.502 133.068 90.183  1.00 50.45 ? 334 GLU A N   1 
ATOM 2200 C CA  . GLU A 1 291 ? 118.763 131.632 90.142  1.00 47.09 ? 334 GLU A CA  1 
ATOM 2201 C C   . GLU A 1 291 ? 118.126 130.921 91.328  1.00 43.45 ? 334 GLU A C   1 
ATOM 2202 O O   . GLU A 1 291 ? 117.542 129.842 91.174  1.00 46.37 ? 334 GLU A O   1 
ATOM 2203 C CB  . GLU A 1 291 ? 120.270 131.364 90.104  1.00 48.23 ? 334 GLU A CB  1 
ATOM 2204 C CG  . GLU A 1 291 ? 120.993 131.691 88.788  1.00 51.90 ? 334 GLU A CG  1 
ATOM 2205 C CD  . GLU A 1 291 ? 120.507 132.958 88.107  1.00 60.91 ? 334 GLU A CD  1 
ATOM 2206 O OE1 . GLU A 1 291 ? 120.205 132.904 86.896  1.00 55.27 ? 334 GLU A OE1 1 
ATOM 2207 O OE2 . GLU A 1 291 ? 120.436 134.010 88.778  1.00 61.50 ? 334 GLU A OE2 1 
ATOM 2208 N N   . LEU A 1 292 ? 118.227 131.510 92.520  1.00 38.92 ? 335 LEU A N   1 
ATOM 2209 C CA  . LEU A 1 292 ? 117.620 130.900 93.698  1.00 42.89 ? 335 LEU A CA  1 
ATOM 2210 C C   . LEU A 1 292 ? 116.100 130.908 93.603  1.00 45.42 ? 335 LEU A C   1 
ATOM 2211 O O   . LEU A 1 292 ? 115.440 129.969 94.061  1.00 52.78 ? 335 LEU A O   1 
ATOM 2212 C CB  . LEU A 1 292 ? 118.089 131.621 94.960  1.00 48.33 ? 335 LEU A CB  1 
ATOM 2213 C CG  . LEU A 1 292 ? 119.603 131.789 95.100  1.00 50.60 ? 335 LEU A CG  1 
ATOM 2214 C CD1 . LEU A 1 292 ? 119.940 132.685 96.278  1.00 48.05 ? 335 LEU A CD1 1 
ATOM 2215 C CD2 . LEU A 1 292 ? 120.285 130.438 95.239  1.00 48.87 ? 335 LEU A CD2 1 
ATOM 2216 N N   . GLN A 1 293 ? 115.528 131.965 93.022  1.00 45.17 ? 336 GLN A N   1 
ATOM 2217 C CA  . GLN A 1 293 ? 114.084 132.001 92.816  1.00 44.33 ? 336 GLN A CA  1 
ATOM 2218 C C   . GLN A 1 293 ? 113.639 130.896 91.869  1.00 49.54 ? 336 GLN A C   1 
ATOM 2219 O O   . GLN A 1 293 ? 112.619 130.238 92.105  1.00 55.75 ? 336 GLN A O   1 
ATOM 2220 C CB  . GLN A 1 293 ? 113.661 133.367 92.278  1.00 46.53 ? 336 GLN A CB  1 
ATOM 2221 C CG  . GLN A 1 293 ? 112.161 133.528 92.114  1.00 46.17 ? 336 GLN A CG  1 
ATOM 2222 C CD  . GLN A 1 293 ? 111.797 134.714 91.248  1.00 51.03 ? 336 GLN A CD  1 
ATOM 2223 O OE1 . GLN A 1 293 ? 112.588 135.155 90.416  1.00 53.22 ? 336 GLN A OE1 1 
ATOM 2224 N NE2 . GLN A 1 293 ? 110.594 135.240 91.441  1.00 54.18 ? 336 GLN A NE2 1 
ATOM 2225 N N   . ALA A 1 294 ? 114.390 130.683 90.787  1.00 48.93 ? 337 ALA A N   1 
ATOM 2226 C CA  . ALA A 1 294 ? 114.059 129.601 89.866  1.00 40.37 ? 337 ALA A CA  1 
ATOM 2227 C C   . ALA A 1 294 ? 114.206 128.241 90.537  1.00 40.35 ? 337 ALA A C   1 
ATOM 2228 O O   . ALA A 1 294 ? 113.390 127.340 90.315  1.00 47.66 ? 337 ALA A O   1 
ATOM 2229 C CB  . ALA A 1 294 ? 114.940 129.683 88.620  1.00 44.63 ? 337 ALA A CB  1 
ATOM 2230 N N   . ALA A 1 295 ? 115.245 128.074 91.358  1.00 49.03 ? 338 ALA A N   1 
ATOM 2231 C CA  . ALA A 1 295 ? 115.463 126.796 92.029  1.00 41.41 ? 338 ALA A CA  1 
ATOM 2232 C C   . ALA A 1 295 ? 114.360 126.493 93.035  1.00 46.02 ? 338 ALA A C   1 
ATOM 2233 O O   . ALA A 1 295 ? 113.868 125.361 93.101  1.00 49.65 ? 338 ALA A O   1 
ATOM 2234 C CB  . ALA A 1 295 ? 116.829 126.790 92.713  1.00 46.55 ? 338 ALA A CB  1 
ATOM 2235 N N   . GLY A 1 296 ? 113.955 127.485 93.824  1.00 48.65 ? 339 GLY A N   1 
ATOM 2236 C CA  . GLY A 1 296 ? 112.913 127.270 94.810  1.00 39.07 ? 339 GLY A CA  1 
ATOM 2237 C C   . GLY A 1 296 ? 113.227 127.806 96.192  1.00 44.26 ? 339 GLY A C   1 
ATOM 2238 O O   . GLY A 1 296 ? 112.516 127.500 97.154  1.00 52.16 ? 339 GLY A O   1 
ATOM 2239 N N   . VAL A 1 297 ? 114.291 128.599 96.311  1.00 45.23 ? 340 VAL A N   1 
ATOM 2240 C CA  . VAL A 1 297 ? 114.638 129.203 97.592  1.00 32.96 ? 340 VAL A CA  1 
ATOM 2241 C C   . VAL A 1 297 ? 113.647 130.312 97.912  1.00 39.11 ? 340 VAL A C   1 
ATOM 2242 O O   . VAL A 1 297 ? 113.314 131.138 97.052  1.00 49.00 ? 340 VAL A O   1 
ATOM 2243 C CB  . VAL A 1 297 ? 116.078 129.733 97.567  1.00 38.04 ? 340 VAL A CB  1 
ATOM 2244 C CG1 . VAL A 1 297 ? 116.549 130.050 98.974  1.00 43.52 ? 340 VAL A CG1 1 
ATOM 2245 C CG2 . VAL A 1 297 ? 117.002 128.722 96.911  1.00 46.97 ? 340 VAL A CG2 1 
ATOM 2246 N N   . LYS A 1 298 ? 113.170 130.339 99.158  1.00 39.88 ? 341 LYS A N   1 
ATOM 2247 C CA  . LYS A 1 298 ? 112.161 131.303 99.578  1.00 43.09 ? 341 LYS A CA  1 
ATOM 2248 C C   . LYS A 1 298 ? 112.580 132.046 100.842 1.00 48.53 ? 341 LYS A C   1 
ATOM 2249 O O   . LYS A 1 298 ? 111.728 132.545 101.582 1.00 45.92 ? 341 LYS A O   1 
ATOM 2250 C CB  . LYS A 1 298 ? 110.811 130.619 99.790  1.00 42.79 ? 341 LYS A CB  1 
ATOM 2251 C CG  . LYS A 1 298 ? 110.196 130.050 98.525  1.00 40.81 ? 341 LYS A CG  1 
ATOM 2252 C CD  . LYS A 1 298 ? 108.695 129.878 98.670  1.00 43.41 ? 341 LYS A CD  1 
ATOM 2253 C CE  . LYS A 1 298 ? 108.037 131.149 99.182  1.00 49.79 ? 341 LYS A CE  1 
ATOM 2254 N NZ  . LYS A 1 298 ? 108.227 132.291 98.244  1.00 48.89 ? 341 LYS A NZ  1 
ATOM 2255 N N   . GLN A 1 299 ? 113.883 132.136 101.104 1.00 46.05 ? 342 GLN A N   1 
ATOM 2256 C CA  . GLN A 1 299 ? 114.370 132.840 102.285 1.00 33.43 ? 342 GLN A CA  1 
ATOM 2257 C C   . GLN A 1 299 ? 115.844 133.161 102.100 1.00 41.06 ? 342 GLN A C   1 
ATOM 2258 O O   . GLN A 1 299 ? 116.624 132.291 101.702 1.00 51.84 ? 342 GLN A O   1 
ATOM 2259 C CB  . GLN A 1 299 ? 114.159 132.004 103.552 1.00 36.79 ? 342 GLN A CB  1 
ATOM 2260 C CG  . GLN A 1 299 ? 113.911 132.826 104.802 1.00 43.95 ? 342 GLN A CG  1 
ATOM 2261 C CD  . GLN A 1 299 ? 113.440 131.984 105.969 1.00 41.46 ? 342 GLN A CD  1 
ATOM 2262 O OE1 . GLN A 1 299 ? 113.996 130.923 106.248 1.00 41.98 ? 342 GLN A OE1 1 
ATOM 2263 N NE2 . GLN A 1 299 ? 112.411 132.455 106.661 1.00 42.05 ? 342 GLN A NE2 1 
ATOM 2264 N N   . ILE A 1 300 ? 116.219 134.405 102.389 1.00 36.13 ? 343 ILE A N   1 
ATOM 2265 C CA  . ILE A 1 300 ? 117.596 134.873 102.282 1.00 32.37 ? 343 ILE A CA  1 
ATOM 2266 C C   . ILE A 1 300 ? 117.983 135.520 103.603 1.00 38.61 ? 343 ILE A C   1 
ATOM 2267 O O   . ILE A 1 300 ? 117.224 136.330 104.146 1.00 51.38 ? 343 ILE A O   1 
ATOM 2268 C CB  . ILE A 1 300 ? 117.776 135.866 101.119 1.00 34.61 ? 343 ILE A CB  1 
ATOM 2269 C CG1 . ILE A 1 300 ? 117.517 135.173 99.781  1.00 44.15 ? 343 ILE A CG1 1 
ATOM 2270 C CG2 . ILE A 1 300 ? 119.166 136.474 101.143 1.00 38.77 ? 343 ILE A CG2 1 
ATOM 2271 C CD1 . ILE A 1 300 ? 118.629 134.252 99.347  1.00 46.71 ? 343 ILE A CD1 1 
ATOM 2272 N N   . THR A 1 301 ? 119.156 135.166 104.120 1.00 37.32 ? 344 THR A N   1 
ATOM 2273 C CA  . THR A 1 301 ? 119.639 135.683 105.390 1.00 37.31 ? 344 THR A CA  1 
ATOM 2274 C C   . THR A 1 301 ? 120.965 136.405 105.201 1.00 40.73 ? 344 THR A C   1 
ATOM 2275 O O   . THR A 1 301 ? 121.778 136.035 104.350 1.00 51.61 ? 344 THR A O   1 
ATOM 2276 C CB  . THR A 1 301 ? 119.805 134.561 106.421 1.00 44.65 ? 344 THR A CB  1 
ATOM 2277 O OG1 . THR A 1 301 ? 120.591 135.030 107.522 1.00 39.36 ? 344 THR A OG1 1 
ATOM 2278 C CG2 . THR A 1 301 ? 120.476 133.363 105.791 1.00 46.22 ? 344 THR A CG2 1 
ATOM 2279 N N   . LEU A 1 302 ? 121.171 137.445 106.005 1.00 39.44 ? 345 LEU A N   1 
ATOM 2280 C CA  . LEU A 1 302 ? 122.379 138.258 105.958 1.00 39.65 ? 345 LEU A CA  1 
ATOM 2281 C C   . LEU A 1 302 ? 123.266 137.891 107.141 1.00 42.67 ? 345 LEU A C   1 
ATOM 2282 O O   . LEU A 1 302 ? 122.848 138.016 108.297 1.00 39.43 ? 345 LEU A O   1 
ATOM 2283 C CB  . LEU A 1 302 ? 122.032 139.745 105.982 1.00 38.54 ? 345 LEU A CB  1 
ATOM 2284 C CG  . LEU A 1 302 ? 123.068 140.705 105.400 1.00 37.43 ? 345 LEU A CG  1 
ATOM 2285 C CD1 . LEU A 1 302 ? 123.458 140.279 103.999 1.00 42.60 ? 345 LEU A CD1 1 
ATOM 2286 C CD2 . LEU A 1 302 ? 122.529 142.122 105.400 1.00 43.27 ? 345 LEU A CD2 1 
ATOM 2287 N N   . ASP A 1 303 ? 124.481 137.440 106.850 1.00 54.46 ? 346 ASP A N   1 
ATOM 2288 C CA  . ASP A 1 303 ? 125.389 136.938 107.869 1.00 50.65 ? 346 ASP A CA  1 
ATOM 2289 C C   . ASP A 1 303 ? 126.333 138.042 108.346 1.00 53.15 ? 346 ASP A C   1 
ATOM 2290 O O   . ASP A 1 303 ? 126.123 139.231 108.089 1.00 58.75 ? 346 ASP A O   1 
ATOM 2291 C CB  . ASP A 1 303 ? 126.148 135.725 107.341 1.00 53.36 ? 346 ASP A CB  1 
ATOM 2292 C CG  . ASP A 1 303 ? 125.702 134.435 107.996 1.00 59.01 ? 346 ASP A CG  1 
ATOM 2293 O OD1 . ASP A 1 303 ? 124.618 134.427 108.617 1.00 59.36 ? 346 ASP A OD1 1 
ATOM 2294 O OD2 . ASP A 1 303 ? 126.433 133.430 107.898 1.00 60.37 ? 346 ASP A OD2 1 
ATOM 2295 N N   . ASP A 1 304 ? 127.383 137.640 109.064 1.00 47.15 ? 347 ASP A N   1 
ATOM 2296 C CA  . ASP A 1 304 ? 128.355 138.527 109.695 1.00 43.96 ? 347 ASP A CA  1 
ATOM 2297 C C   . ASP A 1 304 ? 128.923 139.584 108.757 1.00 44.36 ? 347 ASP A C   1 
ATOM 2298 O O   . ASP A 1 304 ? 128.978 139.385 107.540 1.00 49.71 ? 347 ASP A O   1 
ATOM 2299 C CB  . ASP A 1 304 ? 129.507 137.700 110.271 1.00 52.67 ? 347 ASP A CB  1 
ATOM 2300 C CG  . ASP A 1 304 ? 129.540 137.715 111.781 1.00 58.31 ? 347 ASP A CG  1 
ATOM 2301 O OD1 . ASP A 1 304 ? 128.699 138.410 112.384 1.00 52.73 ? 347 ASP A OD1 1 
ATOM 2302 O OD2 . ASP A 1 304 ? 130.406 137.031 112.366 1.00 54.21 ? 347 ASP A OD2 1 
ATOM 2303 N N   . GLY A 1 305 ? 129.349 140.710 109.322 1.00 43.77 ? 348 GLY A N   1 
ATOM 2304 C CA  . GLY A 1 305 ? 130.057 141.728 108.578 1.00 43.37 ? 348 GLY A CA  1 
ATOM 2305 C C   . GLY A 1 305 ? 129.265 142.956 108.193 1.00 44.44 ? 348 GLY A C   1 
ATOM 2306 O O   . GLY A 1 305 ? 129.800 143.811 107.480 1.00 51.50 ? 348 GLY A O   1 
ATOM 2307 N N   . TRP A 1 306 ? 128.015 143.078 108.636 1.00 41.14 ? 349 TRP A N   1 
ATOM 2308 C CA  . TRP A 1 306 ? 127.189 144.221 108.275 1.00 44.62 ? 349 TRP A CA  1 
ATOM 2309 C C   . TRP A 1 306 ? 127.202 145.336 109.312 1.00 46.17 ? 349 TRP A C   1 
ATOM 2310 O O   . TRP A 1 306 ? 126.655 146.411 109.044 1.00 55.77 ? 349 TRP A O   1 
ATOM 2311 C CB  . TRP A 1 306 ? 125.741 143.775 108.034 1.00 36.22 ? 349 TRP A CB  1 
ATOM 2312 C CG  . TRP A 1 306 ? 125.054 143.240 109.250 1.00 31.35 ? 349 TRP A CG  1 
ATOM 2313 C CD1 . TRP A 1 306 ? 124.960 141.935 109.626 1.00 40.24 ? 349 TRP A CD1 1 
ATOM 2314 C CD2 . TRP A 1 306 ? 124.350 143.994 110.242 1.00 31.77 ? 349 TRP A CD2 1 
ATOM 2315 N NE1 . TRP A 1 306 ? 124.248 141.828 110.794 1.00 38.64 ? 349 TRP A NE1 1 
ATOM 2316 C CE2 . TRP A 1 306 ? 123.864 143.080 111.194 1.00 34.84 ? 349 TRP A CE2 1 
ATOM 2317 C CE3 . TRP A 1 306 ? 124.088 145.355 110.421 1.00 41.08 ? 349 TRP A CE3 1 
ATOM 2318 C CZ2 . TRP A 1 306 ? 123.131 143.481 112.306 1.00 43.83 ? 349 TRP A CZ2 1 
ATOM 2319 C CZ3 . TRP A 1 306 ? 123.363 145.751 111.525 1.00 42.45 ? 349 TRP A CZ3 1 
ATOM 2320 C CH2 . TRP A 1 306 ? 122.892 144.818 112.453 1.00 44.35 ? 349 TRP A CH2 1 
ATOM 2321 N N   . TYR A 1 307 ? 127.812 145.121 110.472 1.00 44.07 ? 350 TYR A N   1 
ATOM 2322 C CA  . TYR A 1 307 ? 127.736 146.064 111.578 1.00 40.35 ? 350 TYR A CA  1 
ATOM 2323 C C   . TYR A 1 307 ? 129.098 146.688 111.852 1.00 44.73 ? 350 TYR A C   1 
ATOM 2324 O O   . TYR A 1 307 ? 130.137 146.216 111.385 1.00 45.30 ? 350 TYR A O   1 
ATOM 2325 C CB  . TYR A 1 307 ? 127.200 145.375 112.840 1.00 44.93 ? 350 TYR A CB  1 
ATOM 2326 C CG  . TYR A 1 307 ? 127.909 144.088 113.203 1.00 43.48 ? 350 TYR A CG  1 
ATOM 2327 C CD1 . TYR A 1 307 ? 127.287 142.861 113.035 1.00 42.79 ? 350 TYR A CD1 1 
ATOM 2328 C CD2 . TYR A 1 307 ? 129.190 144.102 113.740 1.00 44.18 ? 350 TYR A CD2 1 
ATOM 2329 C CE1 . TYR A 1 307 ? 127.925 141.686 113.370 1.00 46.36 ? 350 TYR A CE1 1 
ATOM 2330 C CE2 . TYR A 1 307 ? 129.835 142.931 114.077 1.00 44.26 ? 350 TYR A CE2 1 
ATOM 2331 C CZ  . TYR A 1 307 ? 129.198 141.727 113.892 1.00 44.25 ? 350 TYR A CZ  1 
ATOM 2332 O OH  . TYR A 1 307 ? 129.837 140.557 114.229 1.00 47.95 ? 350 TYR A OH  1 
ATOM 2333 N N   . THR A 1 308 ? 129.074 147.773 112.626 1.00 44.39 ? 351 THR A N   1 
ATOM 2334 C CA  . THR A 1 308 ? 130.293 148.433 113.073 1.00 38.36 ? 351 THR A CA  1 
ATOM 2335 C C   . THR A 1 308 ? 130.789 147.856 114.394 1.00 44.80 ? 351 THR A C   1 
ATOM 2336 O O   . THR A 1 308 ? 131.947 147.439 114.498 1.00 53.76 ? 351 THR A O   1 
ATOM 2337 C CB  . THR A 1 308 ? 130.058 149.940 113.212 1.00 42.61 ? 351 THR A CB  1 
ATOM 2338 O OG1 . THR A 1 308 ? 128.797 150.172 113.849 1.00 43.65 ? 351 THR A OG1 1 
ATOM 2339 C CG2 . THR A 1 308 ? 130.059 150.607 111.847 1.00 47.65 ? 351 THR A CG2 1 
ATOM 2340 N N   . ASN A 1 309 ? 129.926 147.823 115.406 1.00 45.55 ? 352 ASN A N   1 
ATOM 2341 C CA  . ASN A 1 309 ? 130.264 147.244 116.697 1.00 41.61 ? 352 ASN A CA  1 
ATOM 2342 C C   . ASN A 1 309 ? 129.018 146.613 117.297 1.00 39.83 ? 352 ASN A C   1 
ATOM 2343 O O   . ASN A 1 309 ? 127.895 147.046 117.027 1.00 46.54 ? 352 ASN A O   1 
ATOM 2344 C CB  . ASN A 1 309 ? 130.833 148.291 117.661 1.00 39.50 ? 352 ASN A CB  1 
ATOM 2345 C CG  . ASN A 1 309 ? 132.223 148.744 117.276 1.00 45.39 ? 352 ASN A CG  1 
ATOM 2346 O OD1 . ASN A 1 309 ? 133.085 147.929 116.950 1.00 51.13 ? 352 ASN A OD1 1 
ATOM 2347 N ND2 . ASN A 1 309 ? 132.451 150.051 117.309 1.00 45.68 ? 352 ASN A ND2 1 
ATOM 2348 N N   . ALA A 1 310 ? 129.227 145.586 118.112 1.00 45.20 ? 353 ALA A N   1 
ATOM 2349 C CA  . ALA A 1 310 ? 128.122 144.955 118.815 1.00 41.79 ? 353 ALA A CA  1 
ATOM 2350 C C   . ALA A 1 310 ? 127.556 145.899 119.870 1.00 51.14 ? 353 ALA A C   1 
ATOM 2351 O O   . ALA A 1 310 ? 128.280 146.680 120.492 1.00 59.45 ? 353 ALA A O   1 
ATOM 2352 C CB  . ALA A 1 310 ? 128.575 143.649 119.463 1.00 46.32 ? 353 ALA A CB  1 
ATOM 2353 N N   . GLY A 1 311 ? 126.244 145.819 120.068 1.00 51.83 ? 354 GLY A N   1 
ATOM 2354 C CA  . GLY A 1 311 ? 125.567 146.708 120.991 1.00 53.10 ? 354 GLY A CA  1 
ATOM 2355 C C   . GLY A 1 311 ? 125.030 147.946 120.304 1.00 51.42 ? 354 GLY A C   1 
ATOM 2356 O O   . GLY A 1 311 ? 123.829 148.225 120.363 1.00 55.69 ? 354 GLY A O   1 
ATOM 2357 N N   . ASP A 1 312 ? 125.917 148.702 119.653 1.00 48.68 ? 355 ASP A N   1 
ATOM 2358 C CA  . ASP A 1 312 ? 125.469 149.829 118.843 1.00 45.77 ? 355 ASP A CA  1 
ATOM 2359 C C   . ASP A 1 312 ? 124.623 149.354 117.670 1.00 55.92 ? 355 ASP A C   1 
ATOM 2360 O O   . ASP A 1 312 ? 123.570 149.934 117.379 1.00 61.80 ? 355 ASP A O   1 
ATOM 2361 C CB  . ASP A 1 312 ? 126.672 150.628 118.346 1.00 50.76 ? 355 ASP A CB  1 
ATOM 2362 C CG  . ASP A 1 312 ? 127.464 151.251 119.475 1.00 61.92 ? 355 ASP A CG  1 
ATOM 2363 O OD1 . ASP A 1 312 ? 126.885 151.470 120.559 1.00 64.96 ? 355 ASP A OD1 1 
ATOM 2364 O OD2 . ASP A 1 312 ? 128.668 151.522 119.279 1.00 62.63 ? 355 ASP A OD2 1 
ATOM 2365 N N   . TRP A 1 313 ? 125.067 148.294 116.993 1.00 45.61 ? 356 TRP A N   1 
ATOM 2366 C CA  . TRP A 1 313 ? 124.332 147.678 115.887 1.00 40.19 ? 356 TRP A CA  1 
ATOM 2367 C C   . TRP A 1 313 ? 123.997 148.690 114.793 1.00 42.11 ? 356 TRP A C   1 
ATOM 2368 O O   . TRP A 1 313 ? 122.890 148.703 114.251 1.00 52.37 ? 356 TRP A O   1 
ATOM 2369 C CB  . TRP A 1 313 ? 123.067 146.981 116.389 1.00 40.56 ? 356 TRP A CB  1 
ATOM 2370 C CG  . TRP A 1 313 ? 123.333 145.834 117.317 1.00 44.99 ? 356 TRP A CG  1 
ATOM 2371 C CD1 . TRP A 1 313 ? 122.846 145.676 118.580 1.00 48.36 ? 356 TRP A CD1 1 
ATOM 2372 C CD2 . TRP A 1 313 ? 124.141 144.680 117.052 1.00 46.63 ? 356 TRP A CD2 1 
ATOM 2373 N NE1 . TRP A 1 313 ? 123.302 144.500 119.121 1.00 43.49 ? 356 TRP A NE1 1 
ATOM 2374 C CE2 . TRP A 1 313 ? 124.100 143.870 118.203 1.00 43.64 ? 356 TRP A CE2 1 
ATOM 2375 C CE3 . TRP A 1 313 ? 124.897 144.254 115.955 1.00 46.32 ? 356 TRP A CE3 1 
ATOM 2376 C CZ2 . TRP A 1 313 ? 124.783 142.661 118.288 1.00 49.13 ? 356 TRP A CZ2 1 
ATOM 2377 C CZ3 . TRP A 1 313 ? 125.575 143.055 116.043 1.00 45.28 ? 356 TRP A CZ3 1 
ATOM 2378 C CH2 . TRP A 1 313 ? 125.513 142.272 117.200 1.00 46.74 ? 356 TRP A CH2 1 
ATOM 2379 N N   . ALA A 1 314 ? 124.957 149.544 114.466 1.00 33.06 ? 357 ALA A N   1 
ATOM 2380 C CA  . ALA A 1 314 ? 124.797 150.493 113.378 1.00 34.37 ? 357 ALA A CA  1 
ATOM 2381 C C   . ALA A 1 314 ? 125.265 149.875 112.065 1.00 46.68 ? 357 ALA A C   1 
ATOM 2382 O O   . ALA A 1 314 ? 126.096 148.964 112.040 1.00 49.83 ? 357 ALA A O   1 
ATOM 2383 C CB  . ALA A 1 314 ? 125.571 151.779 113.662 1.00 41.04 ? 357 ALA A CB  1 
ATOM 2384 N N   . LEU A 1 315 ? 124.714 150.381 110.965 1.00 46.00 ? 358 LEU A N   1 
ATOM 2385 C CA  . LEU A 1 315 ? 125.069 149.867 109.650 1.00 37.29 ? 358 LEU A CA  1 
ATOM 2386 C C   . LEU A 1 315 ? 126.519 150.195 109.325 1.00 41.96 ? 358 LEU A C   1 
ATOM 2387 O O   . LEU A 1 315 ? 126.979 151.319 109.547 1.00 48.97 ? 358 LEU A O   1 
ATOM 2388 C CB  . LEU A 1 315 ? 124.150 150.451 108.581 1.00 41.71 ? 358 LEU A CB  1 
ATOM 2389 C CG  . LEU A 1 315 ? 122.676 150.066 108.654 1.00 39.28 ? 358 LEU A CG  1 
ATOM 2390 C CD1 . LEU A 1 315 ? 121.916 150.649 107.476 1.00 45.77 ? 358 LEU A CD1 1 
ATOM 2391 C CD2 . LEU A 1 315 ? 122.516 148.559 108.706 1.00 40.77 ? 358 LEU A CD2 1 
ATOM 2392 N N   . ASN A 1 316 ? 127.235 149.215 108.800 1.00 36.50 ? 359 ASN A N   1 
ATOM 2393 C CA  . ASN A 1 316 ? 128.616 149.430 108.394 1.00 39.51 ? 359 ASN A CA  1 
ATOM 2394 C C   . ASN A 1 316 ? 128.642 150.303 107.146 1.00 50.32 ? 359 ASN A C   1 
ATOM 2395 O O   . ASN A 1 316 ? 128.019 149.942 106.138 1.00 55.41 ? 359 ASN A O   1 
ATOM 2396 C CB  . ASN A 1 316 ? 129.305 148.096 108.131 1.00 45.51 ? 359 ASN A CB  1 
ATOM 2397 C CG  . ASN A 1 316 ? 130.808 148.176 108.286 1.00 52.24 ? 359 ASN A CG  1 
ATOM 2398 O OD1 . ASN A 1 316 ? 131.521 148.543 107.354 1.00 53.60 ? 359 ASN A OD1 1 
ATOM 2399 N ND2 . ASN A 1 316 ? 131.299 147.831 109.470 1.00 52.69 ? 359 ASN A ND2 1 
ATOM 2400 N N   . PRO A 1 317 ? 129.323 151.450 107.166 1.00 46.34 ? 360 PRO A N   1 
ATOM 2401 C CA  . PRO A 1 317 ? 129.344 152.308 105.971 1.00 43.36 ? 360 PRO A CA  1 
ATOM 2402 C C   . PRO A 1 317 ? 129.950 151.641 104.750 1.00 50.31 ? 360 PRO A C   1 
ATOM 2403 O O   . PRO A 1 317 ? 129.597 152.004 103.621 1.00 51.71 ? 360 PRO A O   1 
ATOM 2404 C CB  . PRO A 1 317 ? 130.174 153.516 106.426 1.00 42.57 ? 360 PRO A CB  1 
ATOM 2405 C CG  . PRO A 1 317 ? 130.061 153.518 107.913 1.00 48.75 ? 360 PRO A CG  1 
ATOM 2406 C CD  . PRO A 1 317 ? 129.997 152.078 108.313 1.00 46.78 ? 360 PRO A CD  1 
ATOM 2407 N N   . GLU A 1 318 ? 130.860 150.682 104.937 1.00 47.71 ? 361 GLU A N   1 
ATOM 2408 C CA  . GLU A 1 318 ? 131.457 149.999 103.794 1.00 49.70 ? 361 GLU A CA  1 
ATOM 2409 C C   . GLU A 1 318 ? 130.417 149.200 103.019 1.00 49.85 ? 361 GLU A C   1 
ATOM 2410 O O   . GLU A 1 318 ? 130.404 149.217 101.783 1.00 55.55 ? 361 GLU A O   1 
ATOM 2411 C CB  . GLU A 1 318 ? 132.593 149.090 104.262 1.00 54.99 ? 361 GLU A CB  1 
ATOM 2412 C CG  . GLU A 1 318 ? 133.894 149.821 104.551 1.00 56.00 ? 361 GLU A CG  1 
ATOM 2413 C CD  . GLU A 1 318 ? 134.663 150.165 103.291 1.00 58.48 ? 361 GLU A CD  1 
ATOM 2414 O OE1 . GLU A 1 318 ? 134.421 149.518 102.250 1.00 57.83 ? 361 GLU A OE1 1 
ATOM 2415 O OE2 . GLU A 1 318 ? 135.509 151.081 103.341 1.00 57.38 ? 361 GLU A OE2 1 
ATOM 2416 N N   . LYS A 1 319 ? 129.537 148.493 103.726 1.00 40.86 ? 362 LYS A N   1 
ATOM 2417 C CA  . LYS A 1 319 ? 128.504 147.697 103.079 1.00 41.69 ? 362 LYS A CA  1 
ATOM 2418 C C   . LYS A 1 319 ? 127.253 148.497 102.744 1.00 51.63 ? 362 LYS A C   1 
ATOM 2419 O O   . LYS A 1 319 ? 126.523 148.118 101.821 1.00 56.75 ? 362 LYS A O   1 
ATOM 2420 C CB  . LYS A 1 319 ? 128.118 146.508 103.965 1.00 48.73 ? 362 LYS A CB  1 
ATOM 2421 C CG  . LYS A 1 319 ? 129.301 145.768 104.562 1.00 47.38 ? 362 LYS A CG  1 
ATOM 2422 C CD  . LYS A 1 319 ? 129.664 144.549 103.735 1.00 43.80 ? 362 LYS A CD  1 
ATOM 2423 C CE  . LYS A 1 319 ? 130.908 143.869 104.277 1.00 44.63 ? 362 LYS A CE  1 
ATOM 2424 N NZ  . LYS A 1 319 ? 131.125 142.534 103.657 1.00 48.75 ? 362 LYS A NZ  1 
ATOM 2425 N N   . PHE A 1 320 ? 126.988 149.585 103.463 1.00 44.29 ? 363 PHE A N   1 
ATOM 2426 C CA  . PHE A 1 320 ? 125.801 150.413 103.253 1.00 38.27 ? 363 PHE A CA  1 
ATOM 2427 C C   . PHE A 1 320 ? 126.224 151.872 103.146 1.00 39.64 ? 363 PHE A C   1 
ATOM 2428 O O   . PHE A 1 320 ? 126.024 152.661 104.077 1.00 42.62 ? 363 PHE A O   1 
ATOM 2429 C CB  . PHE A 1 320 ? 124.793 150.215 104.384 1.00 40.26 ? 363 PHE A CB  1 
ATOM 2430 C CG  . PHE A 1 320 ? 124.317 148.799 104.533 1.00 37.99 ? 363 PHE A CG  1 
ATOM 2431 C CD1 . PHE A 1 320 ? 124.981 147.915 105.363 1.00 40.62 ? 363 PHE A CD1 1 
ATOM 2432 C CD2 . PHE A 1 320 ? 123.200 148.356 103.850 1.00 39.65 ? 363 PHE A CD2 1 
ATOM 2433 C CE1 . PHE A 1 320 ? 124.542 146.616 105.504 1.00 44.16 ? 363 PHE A CE1 1 
ATOM 2434 C CE2 . PHE A 1 320 ? 122.758 147.058 103.989 1.00 41.83 ? 363 PHE A CE2 1 
ATOM 2435 C CZ  . PHE A 1 320 ? 123.429 146.188 104.817 1.00 38.71 ? 363 PHE A CZ  1 
ATOM 2436 N N   . PRO A 1 321 ? 126.827 152.263 102.019 1.00 41.43 ? 364 PRO A N   1 
ATOM 2437 C CA  . PRO A 1 321 ? 127.318 153.646 101.894 1.00 39.96 ? 364 PRO A CA  1 
ATOM 2438 C C   . PRO A 1 321 ? 126.233 154.704 102.000 1.00 45.39 ? 364 PRO A C   1 
ATOM 2439 O O   . PRO A 1 321 ? 126.501 155.798 102.511 1.00 49.82 ? 364 PRO A O   1 
ATOM 2440 C CB  . PRO A 1 321 ? 127.983 153.659 100.510 1.00 41.73 ? 364 PRO A CB  1 
ATOM 2441 C CG  . PRO A 1 321 ? 127.397 152.499 99.785  1.00 49.87 ? 364 PRO A CG  1 
ATOM 2442 C CD  . PRO A 1 321 ? 127.120 151.461 100.821 1.00 46.33 ? 364 PRO A CD  1 
ATOM 2443 N N   . ASN A 1 322 ? 125.019 154.420 101.536 1.00 48.02 ? 365 ASN A N   1 
ATOM 2444 C CA  . ASN A 1 322 ? 123.950 155.411 101.524 1.00 43.92 ? 365 ASN A CA  1 
ATOM 2445 C C   . ASN A 1 322 ? 123.059 155.350 102.757 1.00 41.73 ? 365 ASN A C   1 
ATOM 2446 O O   . ASN A 1 322 ? 122.085 156.104 102.834 1.00 49.18 ? 365 ASN A O   1 
ATOM 2447 C CB  . ASN A 1 322 ? 123.095 155.249 100.264 1.00 47.03 ? 365 ASN A CB  1 
ATOM 2448 C CG  . ASN A 1 322 ? 123.872 155.527 98.993  1.00 49.13 ? 365 ASN A CG  1 
ATOM 2449 O OD1 . ASN A 1 322 ? 124.277 156.660 98.735  1.00 47.47 ? 365 ASN A OD1 1 
ATOM 2450 N ND2 . ASN A 1 322 ? 124.085 154.492 98.190  1.00 52.72 ? 365 ASN A ND2 1 
ATOM 2451 N N   . GLY A 1 323 ? 123.359 154.478 103.714 1.00 44.72 ? 366 GLY A N   1 
ATOM 2452 C CA  . GLY A 1 323 ? 122.589 154.421 104.940 1.00 38.14 ? 366 GLY A CA  1 
ATOM 2453 C C   . GLY A 1 323 ? 121.418 153.464 104.880 1.00 38.76 ? 366 GLY A C   1 
ATOM 2454 O O   . GLY A 1 323 ? 121.518 152.386 104.288 1.00 45.43 ? 366 GLY A O   1 
ATOM 2455 N N   . ALA A 1 324 ? 120.298 153.851 105.496 1.00 42.31 ? 367 ALA A N   1 
ATOM 2456 C CA  . ALA A 1 324 ? 119.115 153.000 105.502 1.00 41.28 ? 367 ALA A CA  1 
ATOM 2457 C C   . ALA A 1 324 ? 118.532 152.808 104.110 1.00 45.12 ? 367 ALA A C   1 
ATOM 2458 O O   . ALA A 1 324 ? 117.773 151.857 103.894 1.00 51.02 ? 367 ALA A O   1 
ATOM 2459 C CB  . ALA A 1 324 ? 118.054 153.582 106.434 1.00 39.57 ? 367 ALA A CB  1 
ATOM 2460 N N   . SER A 1 325 ? 118.871 153.688 103.164 1.00 46.86 ? 368 SER A N   1 
ATOM 2461 C CA  . SER A 1 325 ? 118.381 153.537 101.799 1.00 45.63 ? 368 SER A CA  1 
ATOM 2462 C C   . SER A 1 325 ? 118.875 152.238 101.174 1.00 52.73 ? 368 SER A C   1 
ATOM 2463 O O   . SER A 1 325 ? 118.113 151.539 100.500 1.00 57.74 ? 368 SER A O   1 
ATOM 2464 C CB  . SER A 1 325 ? 118.810 154.736 100.954 1.00 42.57 ? 368 SER A CB  1 
ATOM 2465 O OG  . SER A 1 325 ? 118.629 155.948 101.663 1.00 47.67 ? 368 SER A OG  1 
ATOM 2466 N N   . ASP A 1 326 ? 120.149 151.900 101.386 1.00 44.95 ? 369 ASP A N   1 
ATOM 2467 C CA  . ASP A 1 326 ? 120.690 150.664 100.826 1.00 42.14 ? 369 ASP A CA  1 
ATOM 2468 C C   . ASP A 1 326 ? 120.031 149.435 101.440 1.00 45.41 ? 369 ASP A C   1 
ATOM 2469 O O   . ASP A 1 326 ? 119.726 148.466 100.730 1.00 57.97 ? 369 ASP A O   1 
ATOM 2470 C CB  . ASP A 1 326 ? 122.202 150.619 101.029 1.00 48.66 ? 369 ASP A CB  1 
ATOM 2471 C CG  . ASP A 1 326 ? 122.920 151.717 100.279 1.00 48.50 ? 369 ASP A CG  1 
ATOM 2472 O OD1 . ASP A 1 326 ? 123.985 152.163 100.753 1.00 53.35 ? 369 ASP A OD1 1 
ATOM 2473 O OD2 . ASP A 1 326 ? 122.419 152.136 99.215  1.00 50.89 ? 369 ASP A OD2 1 
ATOM 2474 N N   . ALA A 1 327 ? 119.817 149.447 102.757 1.00 36.45 ? 370 ALA A N   1 
ATOM 2475 C CA  . ALA A 1 327 ? 119.145 148.325 103.403 1.00 43.95 ? 370 ALA A CA  1 
ATOM 2476 C C   . ALA A 1 327 ? 117.719 148.175 102.894 1.00 45.61 ? 370 ALA A C   1 
ATOM 2477 O O   . ALA A 1 327 ? 117.256 147.057 102.634 1.00 48.53 ? 370 ALA A O   1 
ATOM 2478 C CB  . ALA A 1 327 ? 119.161 148.504 104.919 1.00 43.17 ? 370 ALA A CB  1 
ATOM 2479 N N   . LEU A 1 328 ? 117.008 149.295 102.739 1.00 41.34 ? 371 LEU A N   1 
ATOM 2480 C CA  . LEU A 1 328 ? 115.660 149.242 102.188 1.00 40.40 ? 371 LEU A CA  1 
ATOM 2481 C C   . LEU A 1 328 ? 115.672 148.717 100.760 1.00 50.19 ? 371 LEU A C   1 
ATOM 2482 O O   . LEU A 1 328 ? 114.787 147.952 100.369 1.00 54.02 ? 371 LEU A O   1 
ATOM 2483 C CB  . LEU A 1 328 ? 115.012 150.625 102.249 1.00 44.33 ? 371 LEU A CB  1 
ATOM 2484 C CG  . LEU A 1 328 ? 114.178 150.925 103.494 1.00 44.22 ? 371 LEU A CG  1 
ATOM 2485 C CD1 . LEU A 1 328 ? 113.679 152.359 103.466 1.00 43.87 ? 371 LEU A CD1 1 
ATOM 2486 C CD2 . LEU A 1 328 ? 113.016 149.956 103.604 1.00 47.07 ? 371 LEU A CD2 1 
ATOM 2487 N N   . ARG A 1 329 ? 116.669 149.114 99.967  1.00 45.62 ? 372 ARG A N   1 
ATOM 2488 C CA  . ARG A 1 329 ? 116.770 148.636 98.592  1.00 40.40 ? 372 ARG A CA  1 
ATOM 2489 C C   . ARG A 1 329 ? 116.985 147.127 98.544  1.00 43.46 ? 372 ARG A C   1 
ATOM 2490 O O   . ARG A 1 329 ? 116.336 146.418 97.765  1.00 51.64 ? 372 ARG A O   1 
ATOM 2491 C CB  . ARG A 1 329 ? 117.905 149.369 97.878  1.00 35.86 ? 372 ARG A CB  1 
ATOM 2492 C CG  . ARG A 1 329 ? 118.363 148.721 96.592  1.00 43.20 ? 372 ARG A CG  1 
ATOM 2493 C CD  . ARG A 1 329 ? 119.379 149.595 95.881  1.00 48.41 ? 372 ARG A CD  1 
ATOM 2494 N NE  . ARG A 1 329 ? 120.666 149.600 96.565  1.00 50.64 ? 372 ARG A NE  1 
ATOM 2495 C CZ  . ARG A 1 329 ? 121.806 149.199 96.020  1.00 50.55 ? 372 ARG A CZ  1 
ATOM 2496 N NH1 . ARG A 1 329 ? 121.857 148.749 94.777  1.00 49.56 ? 372 ARG A NH1 1 
ATOM 2497 N NH2 . ARG A 1 329 ? 122.923 149.251 96.739  1.00 51.44 ? 372 ARG A NH2 1 
ATOM 2498 N N   . LEU A 1 330 ? 117.893 146.618 99.379  1.00 42.48 ? 373 LEU A N   1 
ATOM 2499 C CA  . LEU A 1 330 ? 118.142 145.179 99.407  1.00 38.58 ? 373 LEU A CA  1 
ATOM 2500 C C   . LEU A 1 330 ? 116.908 144.413 99.870  1.00 38.23 ? 373 LEU A C   1 
ATOM 2501 O O   . LEU A 1 330 ? 116.541 143.388 99.277  1.00 45.75 ? 373 LEU A O   1 
ATOM 2502 C CB  . LEU A 1 330 ? 119.337 144.872 100.308 1.00 35.35 ? 373 LEU A CB  1 
ATOM 2503 C CG  . LEU A 1 330 ? 119.780 143.410 100.384 1.00 37.98 ? 373 LEU A CG  1 
ATOM 2504 C CD1 . LEU A 1 330 ? 120.139 142.884 99.006  1.00 43.12 ? 373 LEU A CD1 1 
ATOM 2505 C CD2 . LEU A 1 330 ? 120.950 143.258 101.337 1.00 46.00 ? 373 LEU A CD2 1 
ATOM 2506 N N   . THR A 1 331 ? 116.247 144.902 100.923 1.00 33.41 ? 374 THR A N   1 
ATOM 2507 C CA  . THR A 1 331 ? 115.038 144.245 101.409 1.00 40.22 ? 374 THR A CA  1 
ATOM 2508 C C   . THR A 1 331 ? 113.935 144.273 100.358 1.00 47.68 ? 374 THR A C   1 
ATOM 2509 O O   . THR A 1 331 ? 113.212 143.286 100.180 1.00 47.64 ? 374 THR A O   1 
ATOM 2510 C CB  . THR A 1 331 ? 114.573 144.909 102.705 1.00 47.72 ? 374 THR A CB  1 
ATOM 2511 O OG1 . THR A 1 331 ? 115.444 144.526 103.777 1.00 48.87 ? 374 THR A OG1 1 
ATOM 2512 C CG2 . THR A 1 331 ? 113.149 144.499 103.046 1.00 48.69 ? 374 THR A CG2 1 
ATOM 2513 N N   . ASP A 1 332 ? 113.797 145.392 99.645  1.00 51.06 ? 375 ASP A N   1 
ATOM 2514 C CA  . ASP A 1 332 ? 112.787 145.497 98.600  1.00 49.33 ? 375 ASP A CA  1 
ATOM 2515 C C   . ASP A 1 332 ? 113.070 144.535 97.455  1.00 52.72 ? 375 ASP A C   1 
ATOM 2516 O O   . ASP A 1 332 ? 112.145 143.922 96.917  1.00 56.93 ? 375 ASP A O   1 
ATOM 2517 C CB  . ASP A 1 332 ? 112.710 146.934 98.087  1.00 47.85 ? 375 ASP A CB  1 
ATOM 2518 C CG  . ASP A 1 332 ? 112.027 147.865 99.068  1.00 57.16 ? 375 ASP A CG  1 
ATOM 2519 O OD1 . ASP A 1 332 ? 111.395 147.365 100.022 1.00 57.35 ? 375 ASP A OD1 1 
ATOM 2520 O OD2 . ASP A 1 332 ? 112.123 149.097 98.886  1.00 56.09 ? 375 ASP A OD2 1 
ATOM 2521 N N   . ALA A 1 333 ? 114.339 144.393 97.063  1.00 40.48 ? 376 ALA A N   1 
ATOM 2522 C CA  . ALA A 1 333 ? 114.679 143.430 96.019  1.00 39.62 ? 376 ALA A CA  1 
ATOM 2523 C C   . ALA A 1 333 ? 114.351 142.007 96.459  1.00 40.50 ? 376 ALA A C   1 
ATOM 2524 O O   . ALA A 1 333 ? 113.757 141.226 95.700  1.00 44.97 ? 376 ALA A O   1 
ATOM 2525 C CB  . ALA A 1 333 ? 116.156 143.556 95.651  1.00 40.82 ? 376 ALA A CB  1 
ATOM 2526 N N   . ILE A 1 334 ? 114.714 141.661 97.697  1.00 37.95 ? 377 ILE A N   1 
ATOM 2527 C CA  . ILE A 1 334 ? 114.427 140.323 98.208  1.00 35.34 ? 377 ILE A CA  1 
ATOM 2528 C C   . ILE A 1 334 ? 112.924 140.069 98.231  1.00 41.56 ? 377 ILE A C   1 
ATOM 2529 O O   . ILE A 1 334 ? 112.453 138.998 97.830  1.00 46.40 ? 377 ILE A O   1 
ATOM 2530 C CB  . ILE A 1 334 ? 115.056 140.136 99.601  1.00 42.73 ? 377 ILE A CB  1 
ATOM 2531 C CG1 . ILE A 1 334 ? 116.581 140.176 99.505  1.00 46.19 ? 377 ILE A CG1 1 
ATOM 2532 C CG2 . ILE A 1 334 ? 114.601 138.830 100.225 1.00 48.20 ? 377 ILE A CG2 1 
ATOM 2533 C CD1 . ILE A 1 334 ? 117.275 140.120 100.845 1.00 44.57 ? 377 ILE A CD1 1 
ATOM 2534 N N   . HIS A 1 335 ? 112.148 141.049 98.699  1.00 41.57 ? 378 HIS A N   1 
ATOM 2535 C CA  . HIS A 1 335 ? 110.698 140.894 98.751  1.00 34.97 ? 378 HIS A CA  1 
ATOM 2536 C C   . HIS A 1 335 ? 110.098 140.791 97.355  1.00 42.12 ? 378 HIS A C   1 
ATOM 2537 O O   . HIS A 1 335 ? 109.158 140.020 97.133  1.00 51.24 ? 378 HIS A O   1 
ATOM 2538 C CB  . HIS A 1 335 ? 110.077 142.060 99.517  1.00 39.56 ? 378 HIS A CB  1 
ATOM 2539 C CG  . HIS A 1 335 ? 110.264 141.975 100.998 1.00 41.91 ? 378 HIS A CG  1 
ATOM 2540 N ND1 . HIS A 1 335 ? 110.471 140.781 101.654 1.00 48.02 ? 378 HIS A ND1 1 
ATOM 2541 C CD2 . HIS A 1 335 ? 110.274 142.935 101.952 1.00 43.58 ? 378 HIS A CD2 1 
ATOM 2542 C CE1 . HIS A 1 335 ? 110.601 141.010 102.949 1.00 45.96 ? 378 HIS A CE1 1 
ATOM 2543 N NE2 . HIS A 1 335 ? 110.485 142.309 103.155 1.00 46.43 ? 378 HIS A NE2 1 
ATOM 2544 N N   . GLU A 1 336 ? 110.621 141.567 96.404  1.00 45.12 ? 379 GLU A N   1 
ATOM 2545 C CA  . GLU A 1 336 ? 110.125 141.508 95.034  1.00 42.62 ? 379 GLU A CA  1 
ATOM 2546 C C   . GLU A 1 336 ? 110.369 140.136 94.425  1.00 44.94 ? 379 GLU A C   1 
ATOM 2547 O O   . GLU A 1 336 ? 109.527 139.622 93.680  1.00 45.66 ? 379 GLU A O   1 
ATOM 2548 C CB  . GLU A 1 336 ? 110.782 142.604 94.194  1.00 42.08 ? 379 GLU A CB  1 
ATOM 2549 C CG  . GLU A 1 336 ? 111.188 142.175 92.794  1.00 48.84 ? 379 GLU A CG  1 
ATOM 2550 C CD  . GLU A 1 336 ? 111.866 143.286 92.018  1.00 54.14 ? 379 GLU A CD  1 
ATOM 2551 O OE1 . GLU A 1 336 ? 112.450 144.186 92.656  1.00 54.48 ? 379 GLU A OE1 1 
ATOM 2552 O OE2 . GLU A 1 336 ? 111.814 143.260 90.771  1.00 54.13 ? 379 GLU A OE2 1 
ATOM 2553 N N   . HIS A 1 337 ? 111.507 139.519 94.739  1.00 47.06 ? 380 HIS A N   1 
ATOM 2554 C CA  . HIS A 1 337 ? 111.760 138.166 94.260  1.00 36.74 ? 380 HIS A CA  1 
ATOM 2555 C C   . HIS A 1 337 ? 111.071 137.094 95.104  1.00 39.28 ? 380 HIS A C   1 
ATOM 2556 O O   . HIS A 1 337 ? 111.434 135.917 95.006  1.00 44.32 ? 380 HIS A O   1 
ATOM 2557 C CB  . HIS A 1 337 ? 113.264 137.905 94.187  1.00 35.14 ? 380 HIS A CB  1 
ATOM 2558 C CG  . HIS A 1 337 ? 113.928 138.566 93.021  1.00 33.64 ? 380 HIS A CG  1 
ATOM 2559 N ND1 . HIS A 1 337 ? 114.536 139.799 93.110  1.00 43.70 ? 380 HIS A ND1 1 
ATOM 2560 C CD2 . HIS A 1 337 ? 114.066 138.172 91.733  1.00 42.14 ? 380 HIS A CD2 1 
ATOM 2561 C CE1 . HIS A 1 337 ? 115.027 140.132 91.931  1.00 43.05 ? 380 HIS A CE1 1 
ATOM 2562 N NE2 . HIS A 1 337 ? 114.755 139.162 91.077  1.00 44.32 ? 380 HIS A NE2 1 
ATOM 2563 N N   . GLY A 1 338 ? 110.092 137.474 95.922  1.00 39.91 ? 381 GLY A N   1 
ATOM 2564 C CA  . GLY A 1 338 ? 109.263 136.508 96.615  1.00 38.56 ? 381 GLY A CA  1 
ATOM 2565 C C   . GLY A 1 338 ? 109.892 135.817 97.801  1.00 37.97 ? 381 GLY A C   1 
ATOM 2566 O O   . GLY A 1 338 ? 109.448 134.726 98.168  1.00 43.04 ? 381 GLY A O   1 
ATOM 2567 N N   . MET A 1 339 ? 110.907 136.413 98.420  1.00 43.16 ? 382 MET A N   1 
ATOM 2568 C CA  . MET A 1 339 ? 111.590 135.800 99.549  1.00 38.12 ? 382 MET A CA  1 
ATOM 2569 C C   . MET A 1 339 ? 111.593 136.748 100.739 1.00 46.83 ? 382 MET A C   1 
ATOM 2570 O O   . MET A 1 339 ? 111.412 137.960 100.599 1.00 50.93 ? 382 MET A O   1 
ATOM 2571 C CB  . MET A 1 339 ? 113.030 135.408 99.194  1.00 43.46 ? 382 MET A CB  1 
ATOM 2572 C CG  . MET A 1 339 ? 113.263 135.150 97.719  1.00 41.79 ? 382 MET A CG  1 
ATOM 2573 S SD  . MET A 1 339 ? 114.822 134.306 97.405  1.00 59.45 ? 382 MET A SD  1 
ATOM 2574 C CE  . MET A 1 339 ? 114.855 134.313 95.616  1.00 50.80 ? 382 MET A CE  1 
ATOM 2575 N N   . THR A 1 340 ? 111.798 136.173 101.920 1.00 47.29 ? 383 THR A N   1 
ATOM 2576 C CA  . THR A 1 340 ? 111.919 136.919 103.163 1.00 42.45 ? 383 THR A CA  1 
ATOM 2577 C C   . THR A 1 340 ? 113.389 137.138 103.508 1.00 48.25 ? 383 THR A C   1 
ATOM 2578 O O   . THR A 1 340 ? 114.281 136.458 102.994 1.00 53.28 ? 383 THR A O   1 
ATOM 2579 C CB  . THR A 1 340 ? 111.214 136.188 104.307 1.00 33.95 ? 383 THR A CB  1 
ATOM 2580 O OG1 . THR A 1 340 ? 111.378 134.775 104.146 1.00 48.20 ? 383 THR A OG1 1 
ATOM 2581 C CG2 . THR A 1 340 ? 109.734 136.520 104.313 1.00 38.69 ? 383 THR A CG2 1 
ATOM 2582 N N   . ALA A 1 341 ? 113.633 138.103 104.392 1.00 39.22 ? 384 ALA A N   1 
ATOM 2583 C CA  . ALA A 1 341 ? 114.981 138.511 104.760 1.00 36.96 ? 384 ALA A CA  1 
ATOM 2584 C C   . ALA A 1 341 ? 115.190 138.365 106.261 1.00 38.45 ? 384 ALA A C   1 
ATOM 2585 O O   . ALA A 1 341 ? 114.306 138.696 107.056 1.00 48.52 ? 384 ALA A O   1 
ATOM 2586 C CB  . ALA A 1 341 ? 115.253 139.955 104.335 1.00 39.28 ? 384 ALA A CB  1 
ATOM 2587 N N   . LEU A 1 342 ? 116.367 137.869 106.640 1.00 33.26 ? 385 LEU A N   1 
ATOM 2588 C CA  . LEU A 1 342 ? 116.751 137.702 108.034 1.00 40.11 ? 385 LEU A CA  1 
ATOM 2589 C C   . LEU A 1 342 ? 118.069 138.424 108.283 1.00 48.55 ? 385 LEU A C   1 
ATOM 2590 O O   . LEU A 1 342 ? 118.752 138.855 107.350 1.00 49.31 ? 385 LEU A O   1 
ATOM 2591 C CB  . LEU A 1 342 ? 116.872 136.220 108.409 1.00 41.55 ? 385 LEU A CB  1 
ATOM 2592 C CG  . LEU A 1 342 ? 115.760 135.298 107.909 1.00 46.82 ? 385 LEU A CG  1 
ATOM 2593 C CD1 . LEU A 1 342 ? 116.065 133.858 108.268 1.00 45.01 ? 385 LEU A CD1 1 
ATOM 2594 C CD2 . LEU A 1 342 ? 114.416 135.718 108.471 1.00 47.45 ? 385 LEU A CD2 1 
ATOM 2595 N N   . LEU A 1 343 ? 118.427 138.555 109.560 1.00 53.74 ? 386 LEU A N   1 
ATOM 2596 C CA  . LEU A 1 343 ? 119.607 139.311 109.957 1.00 48.51 ? 386 LEU A CA  1 
ATOM 2597 C C   . LEU A 1 343 ? 120.403 138.550 111.008 1.00 49.87 ? 386 LEU A C   1 
ATOM 2598 O O   . LEU A 1 343 ? 119.827 137.911 111.893 1.00 47.89 ? 386 LEU A O   1 
ATOM 2599 C CB  . LEU A 1 343 ? 119.220 140.693 110.499 1.00 45.11 ? 386 LEU A CB  1 
ATOM 2600 C CG  . LEU A 1 343 ? 120.307 141.769 110.493 1.00 46.09 ? 386 LEU A CG  1 
ATOM 2601 C CD1 . LEU A 1 343 ? 120.872 141.951 109.097 1.00 46.12 ? 386 LEU A CD1 1 
ATOM 2602 C CD2 . LEU A 1 343 ? 119.764 143.081 111.027 1.00 48.61 ? 386 LEU A CD2 1 
ATOM 2603 N N   . TRP A 1 344 ? 121.728 138.626 110.902 1.00 53.14 ? 387 TRP A N   1 
ATOM 2604 C CA  . TRP A 1 344 ? 122.612 138.047 111.904 1.00 47.74 ? 387 TRP A CA  1 
ATOM 2605 C C   . TRP A 1 344 ? 122.604 138.900 113.168 1.00 49.27 ? 387 TRP A C   1 
ATOM 2606 O O   . TRP A 1 344 ? 122.364 140.110 113.124 1.00 57.16 ? 387 TRP A O   1 
ATOM 2607 C CB  . TRP A 1 344 ? 124.034 137.931 111.355 1.00 50.36 ? 387 TRP A CB  1 
ATOM 2608 C CG  . TRP A 1 344 ? 124.942 137.069 112.178 1.00 50.36 ? 387 TRP A CG  1 
ATOM 2609 C CD1 . TRP A 1 344 ? 125.128 135.725 112.052 1.00 51.75 ? 387 TRP A CD1 1 
ATOM 2610 C CD2 . TRP A 1 344 ? 125.791 137.492 113.251 1.00 48.31 ? 387 TRP A CD2 1 
ATOM 2611 N NE1 . TRP A 1 344 ? 126.038 135.284 112.980 1.00 48.68 ? 387 TRP A NE1 1 
ATOM 2612 C CE2 . TRP A 1 344 ? 126.460 136.350 113.729 1.00 48.91 ? 387 TRP A CE2 1 
ATOM 2613 C CE3 . TRP A 1 344 ? 126.048 138.726 113.856 1.00 49.98 ? 387 TRP A CE3 1 
ATOM 2614 C CZ2 . TRP A 1 344 ? 127.370 136.404 114.781 1.00 54.19 ? 387 TRP A CZ2 1 
ATOM 2615 C CZ3 . TRP A 1 344 ? 126.951 138.777 114.900 1.00 48.81 ? 387 TRP A CZ3 1 
ATOM 2616 C CH2 . TRP A 1 344 ? 127.601 137.624 115.352 1.00 51.99 ? 387 TRP A CH2 1 
ATOM 2617 N N   . TRP A 1 345 ? 122.882 138.263 114.304 1.00 47.10 ? 388 TRP A N   1 
ATOM 2618 C CA  . TRP A 1 345 ? 122.690 138.935 115.581 1.00 44.91 ? 388 TRP A CA  1 
ATOM 2619 C C   . TRP A 1 345 ? 123.363 138.141 116.692 1.00 54.60 ? 388 TRP A C   1 
ATOM 2620 O O   . TRP A 1 345 ? 123.329 136.908 116.685 1.00 59.97 ? 388 TRP A O   1 
ATOM 2621 C CB  . TRP A 1 345 ? 121.191 139.094 115.872 1.00 48.30 ? 388 TRP A CB  1 
ATOM 2622 C CG  . TRP A 1 345 ? 120.868 139.818 117.129 1.00 50.42 ? 388 TRP A CG  1 
ATOM 2623 C CD1 . TRP A 1 345 ? 121.514 140.902 117.643 1.00 52.13 ? 388 TRP A CD1 1 
ATOM 2624 C CD2 . TRP A 1 345 ? 119.803 139.517 118.033 1.00 48.91 ? 388 TRP A CD2 1 
ATOM 2625 N NE1 . TRP A 1 345 ? 120.918 141.293 118.817 1.00 50.12 ? 388 TRP A NE1 1 
ATOM 2626 C CE2 . TRP A 1 345 ? 119.864 140.458 119.078 1.00 48.57 ? 388 TRP A CE2 1 
ATOM 2627 C CE3 . TRP A 1 345 ? 118.804 138.541 118.062 1.00 51.89 ? 388 TRP A CE3 1 
ATOM 2628 C CZ2 . TRP A 1 345 ? 118.967 140.451 120.140 1.00 50.88 ? 388 TRP A CZ2 1 
ATOM 2629 C CZ3 . TRP A 1 345 ? 117.914 138.536 119.117 1.00 56.31 ? 388 TRP A CZ3 1 
ATOM 2630 C CH2 . TRP A 1 345 ? 118.001 139.484 120.142 1.00 52.94 ? 388 TRP A CH2 1 
ATOM 2631 N N   . ARG A 1 346 ? 123.970 138.856 117.637 1.00 50.13 ? 389 ARG A N   1 
ATOM 2632 C CA  . ARG A 1 346 ? 124.507 138.269 118.867 1.00 45.71 ? 389 ARG A CA  1 
ATOM 2633 C C   . ARG A 1 346 ? 123.782 138.894 120.049 1.00 38.90 ? 389 ARG A C   1 
ATOM 2634 O O   . ARG A 1 346 ? 124.069 140.046 120.417 1.00 52.97 ? 389 ARG A O   1 
ATOM 2635 C CB  . ARG A 1 346 ? 126.014 138.491 118.976 1.00 47.98 ? 389 ARG A CB  1 
ATOM 2636 C CG  . ARG A 1 346 ? 126.691 137.608 120.010 1.00 43.23 ? 389 ARG A CG  1 
ATOM 2637 C CD  . ARG A 1 346 ? 128.161 137.953 120.160 1.00 44.06 ? 389 ARG A CD  1 
ATOM 2638 N NE  . ARG A 1 346 ? 128.999 137.185 119.249 1.00 42.34 ? 389 ARG A NE  1 
ATOM 2639 C CZ  . ARG A 1 346 ? 129.884 137.717 118.417 1.00 43.03 ? 389 ARG A CZ  1 
ATOM 2640 N NH1 . ARG A 1 346 ? 130.071 139.024 118.352 1.00 44.93 ? 389 ARG A NH1 1 
ATOM 2641 N NH2 . ARG A 1 346 ? 130.596 136.917 117.630 1.00 51.31 ? 389 ARG A NH2 1 
ATOM 2642 N N   . PRO A 1 347 ? 122.840 138.181 120.673 1.00 42.09 ? 390 PRO A N   1 
ATOM 2643 C CA  . PRO A 1 347 ? 121.894 138.828 121.596 1.00 51.50 ? 390 PRO A CA  1 
ATOM 2644 C C   . PRO A 1 347 ? 122.507 139.550 122.789 1.00 57.83 ? 390 PRO A C   1 
ATOM 2645 O O   . PRO A 1 347 ? 122.308 140.758 122.948 1.00 60.45 ? 390 PRO A O   1 
ATOM 2646 C CB  . PRO A 1 347 ? 121.024 137.656 122.066 1.00 51.32 ? 390 PRO A CB  1 
ATOM 2647 C CG  . PRO A 1 347 ? 121.095 136.673 120.955 1.00 57.16 ? 390 PRO A CG  1 
ATOM 2648 C CD  . PRO A 1 347 ? 122.495 136.772 120.427 1.00 54.28 ? 390 PRO A CD  1 
ATOM 2649 N N   . CYS A 1 348 ? 123.254 138.837 123.628 1.00 52.11 ? 391 CYS A N   1 
ATOM 2650 C CA  . CYS A 1 348 ? 123.663 139.379 124.919 1.00 46.07 ? 391 CYS A CA  1 
ATOM 2651 C C   . CYS A 1 348 ? 124.923 140.231 124.851 1.00 48.14 ? 391 CYS A C   1 
ATOM 2652 O O   . CYS A 1 348 ? 125.345 140.758 125.886 1.00 55.58 ? 391 CYS A O   1 
ATOM 2653 C CB  . CYS A 1 348 ? 123.871 138.241 125.922 1.00 51.77 ? 391 CYS A CB  1 
ATOM 2654 S SG  . CYS A 1 348 ? 122.577 136.984 125.903 1.00 66.32 ? 391 CYS A SG  1 
ATOM 2655 N N   . ASP A 1 349 ? 125.532 140.381 123.680 1.00 43.02 ? 392 ASP A N   1 
ATOM 2656 C CA  . ASP A 1 349 ? 126.769 141.136 123.583 1.00 41.19 ? 392 ASP A CA  1 
ATOM 2657 C C   . ASP A 1 349 ? 126.507 142.632 123.732 1.00 40.53 ? 392 ASP A C   1 
ATOM 2658 O O   . ASP A 1 349 ? 125.406 143.130 123.483 1.00 42.74 ? 392 ASP A O   1 
ATOM 2659 C CB  . ASP A 1 349 ? 127.465 140.859 122.252 1.00 50.44 ? 392 ASP A CB  1 
ATOM 2660 C CG  . ASP A 1 349 ? 128.966 141.030 122.336 1.00 53.75 ? 392 ASP A CG  1 
ATOM 2661 O OD1 . ASP A 1 349 ? 129.495 141.093 123.465 1.00 49.22 ? 392 ASP A OD1 1 
ATOM 2662 O OD2 . ASP A 1 349 ? 129.619 141.100 121.274 1.00 56.99 ? 392 ASP A OD2 1 
ATOM 2663 N N   . GLY A 1 350 ? 127.545 143.350 124.149 1.00 38.86 ? 393 GLY A N   1 
ATOM 2664 C CA  . GLY A 1 350 ? 127.464 144.787 124.305 1.00 35.27 ? 393 GLY A CA  1 
ATOM 2665 C C   . GLY A 1 350 ? 128.711 145.494 123.822 1.00 35.15 ? 393 GLY A C   1 
ATOM 2666 O O   . GLY A 1 350 ? 128.813 146.720 123.909 1.00 48.79 ? 393 GLY A O   1 
ATOM 2667 N N   . GLY A 1 351 ? 129.670 144.728 123.314 1.00 34.97 ? 394 GLY A N   1 
ATOM 2668 C CA  . GLY A 1 351 ? 130.873 145.287 122.739 1.00 40.42 ? 394 GLY A CA  1 
ATOM 2669 C C   . GLY A 1 351 ? 131.930 145.625 123.774 1.00 41.31 ? 394 GLY A C   1 
ATOM 2670 O O   . GLY A 1 351 ? 131.714 145.579 124.985 1.00 49.33 ? 394 GLY A O   1 
ATOM 2671 N N   . ILE A 1 352 ? 133.112 145.974 123.265 1.00 45.18 ? 395 ILE A N   1 
ATOM 2672 C CA  . ILE A 1 352 ? 134.239 146.410 124.079 1.00 45.09 ? 395 ILE A CA  1 
ATOM 2673 C C   . ILE A 1 352 ? 134.591 147.867 123.801 1.00 47.69 ? 395 ILE A C   1 
ATOM 2674 O O   . ILE A 1 352 ? 134.784 148.660 124.727 1.00 53.93 ? 395 ILE A O   1 
ATOM 2675 C CB  . ILE A 1 352 ? 135.472 145.503 123.865 1.00 42.99 ? 395 ILE A CB  1 
ATOM 2676 C CG1 . ILE A 1 352 ? 135.106 144.038 124.097 1.00 47.03 ? 395 ILE A CG1 1 
ATOM 2677 C CG2 . ILE A 1 352 ? 136.614 145.926 124.773 1.00 45.21 ? 395 ILE A CG2 1 
ATOM 2678 C CD1 . ILE A 1 352 ? 135.993 143.066 123.353 1.00 47.27 ? 395 ILE A CD1 1 
ATOM 2679 N N   . ASP A 1 353 ? 134.678 148.237 122.523 1.00 45.73 ? 396 ASP A N   1 
ATOM 2680 C CA  . ASP A 1 353 ? 134.956 149.606 122.113 1.00 45.12 ? 396 ASP A CA  1 
ATOM 2681 C C   . ASP A 1 353 ? 133.721 150.300 121.550 1.00 49.99 ? 396 ASP A C   1 
ATOM 2682 O O   . ASP A 1 353 ? 133.845 151.286 120.818 1.00 54.62 ? 396 ASP A O   1 
ATOM 2683 C CB  . ASP A 1 353 ? 136.090 149.631 121.088 1.00 51.73 ? 396 ASP A CB  1 
ATOM 2684 C CG  . ASP A 1 353 ? 137.440 149.324 121.706 1.00 57.03 ? 396 ASP A CG  1 
ATOM 2685 O OD1 . ASP A 1 353 ? 137.555 149.385 122.948 1.00 57.66 ? 396 ASP A OD1 1 
ATOM 2686 O OD2 . ASP A 1 353 ? 138.387 149.021 120.949 1.00 58.06 ? 396 ASP A OD2 1 
ATOM 2687 N N   . SER A 1 354 ? 132.532 149.802 121.874 1.00 50.64 ? 397 SER A N   1 
ATOM 2688 C CA  . SER A 1 354 ? 131.299 150.367 121.354 1.00 49.23 ? 397 SER A CA  1 
ATOM 2689 C C   . SER A 1 354 ? 130.946 151.662 122.077 1.00 51.42 ? 397 SER A C   1 
ATOM 2690 O O   . SER A 1 354 ? 131.436 151.953 123.171 1.00 56.15 ? 397 SER A O   1 
ATOM 2691 C CB  . SER A 1 354 ? 130.152 149.367 121.489 1.00 52.40 ? 397 SER A CB  1 
ATOM 2692 O OG  . SER A 1 354 ? 129.859 149.112 122.850 1.00 49.67 ? 397 SER A OG  1 
ATOM 2693 N N   . ILE A 1 355 ? 130.079 152.451 121.437 1.00 47.16 ? 398 ILE A N   1 
ATOM 2694 C CA  . ILE A 1 355 ? 129.607 153.689 122.046 1.00 44.11 ? 398 ILE A CA  1 
ATOM 2695 C C   . ILE A 1 355 ? 128.754 153.395 123.272 1.00 42.66 ? 398 ILE A C   1 
ATOM 2696 O O   . ILE A 1 355 ? 128.703 154.200 124.211 1.00 50.91 ? 398 ILE A O   1 
ATOM 2697 C CB  . ILE A 1 355 ? 128.845 154.532 121.007 1.00 45.74 ? 398 ILE A CB  1 
ATOM 2698 C CG1 . ILE A 1 355 ? 129.684 154.693 119.739 1.00 45.55 ? 398 ILE A CG1 1 
ATOM 2699 C CG2 . ILE A 1 355 ? 128.488 155.893 121.575 1.00 50.92 ? 398 ILE A CG2 1 
ATOM 2700 C CD1 . ILE A 1 355 ? 129.110 155.677 118.747 1.00 47.26 ? 398 ILE A CD1 1 
ATOM 2701 N N   . LEU A 1 356 ? 128.081 152.242 123.292 1.00 43.19 ? 399 LEU A N   1 
ATOM 2702 C CA  . LEU A 1 356 ? 127.267 151.877 124.448 1.00 48.86 ? 399 LEU A CA  1 
ATOM 2703 C C   . LEU A 1 356 ? 128.116 151.761 125.707 1.00 55.54 ? 399 LEU A C   1 
ATOM 2704 O O   . LEU A 1 356 ? 127.707 152.209 126.784 1.00 57.16 ? 399 LEU A O   1 
ATOM 2705 C CB  . LEU A 1 356 ? 126.528 150.569 124.172 1.00 48.82 ? 399 LEU A CB  1 
ATOM 2706 C CG  . LEU A 1 356 ? 125.355 150.230 125.091 1.00 45.00 ? 399 LEU A CG  1 
ATOM 2707 C CD1 . LEU A 1 356 ? 124.249 151.259 124.951 1.00 52.47 ? 399 LEU A CD1 1 
ATOM 2708 C CD2 . LEU A 1 356 ? 124.834 148.838 124.791 1.00 45.71 ? 399 LEU A CD2 1 
ATOM 2709 N N   . TYR A 1 357 ? 129.302 151.160 125.595 1.00 54.42 ? 400 TYR A N   1 
ATOM 2710 C CA  . TYR A 1 357 ? 130.207 151.096 126.736 1.00 48.58 ? 400 TYR A CA  1 
ATOM 2711 C C   . TYR A 1 357 ? 130.902 152.426 126.990 1.00 51.84 ? 400 TYR A C   1 
ATOM 2712 O O   . TYR A 1 357 ? 131.164 152.769 128.148 1.00 57.78 ? 400 TYR A O   1 
ATOM 2713 C CB  . TYR A 1 357 ? 131.250 149.997 126.530 1.00 50.42 ? 400 TYR A CB  1 
ATOM 2714 C CG  . TYR A 1 357 ? 132.141 149.774 127.733 1.00 55.84 ? 400 TYR A CG  1 
ATOM 2715 C CD1 . TYR A 1 357 ? 131.734 148.959 128.780 1.00 55.39 ? 400 TYR A CD1 1 
ATOM 2716 C CD2 . TYR A 1 357 ? 133.384 150.383 127.823 1.00 53.92 ? 400 TYR A CD2 1 
ATOM 2717 C CE1 . TYR A 1 357 ? 132.540 148.756 129.880 1.00 49.78 ? 400 TYR A CE1 1 
ATOM 2718 C CE2 . TYR A 1 357 ? 134.196 150.186 128.921 1.00 53.11 ? 400 TYR A CE2 1 
ATOM 2719 C CZ  . TYR A 1 357 ? 133.769 149.372 129.946 1.00 52.21 ? 400 TYR A CZ  1 
ATOM 2720 O OH  . TYR A 1 357 ? 134.576 149.172 131.041 1.00 52.63 ? 400 TYR A OH  1 
ATOM 2721 N N   . GLN A 1 358 ? 131.215 153.176 125.932 1.00 50.89 ? 401 GLN A N   1 
ATOM 2722 C CA  . GLN A 1 358 ? 131.906 154.449 126.105 1.00 49.72 ? 401 GLN A CA  1 
ATOM 2723 C C   . GLN A 1 358 ? 131.053 155.443 126.882 1.00 54.48 ? 401 GLN A C   1 
ATOM 2724 O O   . GLN A 1 358 ? 131.563 156.168 127.744 1.00 59.72 ? 401 GLN A O   1 
ATOM 2725 C CB  . GLN A 1 358 ? 132.293 155.025 124.745 1.00 51.58 ? 401 GLN A CB  1 
ATOM 2726 C CG  . GLN A 1 358 ? 133.702 154.679 124.302 1.00 57.03 ? 401 GLN A CG  1 
ATOM 2727 C CD  . GLN A 1 358 ? 134.073 155.330 122.985 1.00 61.46 ? 401 GLN A CD  1 
ATOM 2728 O OE1 . GLN A 1 358 ? 134.294 154.649 121.984 1.00 59.97 ? 401 GLN A OE1 1 
ATOM 2729 N NE2 . GLN A 1 358 ? 134.142 156.655 122.980 1.00 59.64 ? 401 GLN A NE2 1 
ATOM 2730 N N   . GLN A 1 359 ? 129.754 155.493 126.593 1.00 56.81 ? 402 GLN A N   1 
ATOM 2731 C CA  . GLN A 1 359 ? 128.870 156.464 127.223 1.00 55.12 ? 402 GLN A CA  1 
ATOM 2732 C C   . GLN A 1 359 ? 128.119 155.919 128.426 1.00 47.93 ? 402 GLN A C   1 
ATOM 2733 O O   . GLN A 1 359 ? 127.796 156.689 129.335 1.00 58.18 ? 402 GLN A O   1 
ATOM 2734 C CB  . GLN A 1 359 ? 127.856 156.999 126.207 1.00 58.69 ? 402 GLN A CB  1 
ATOM 2735 C CG  . GLN A 1 359 ? 128.383 158.125 125.335 1.00 60.60 ? 402 GLN A CG  1 
ATOM 2736 C CD  . GLN A 1 359 ? 127.524 158.361 124.111 1.00 61.25 ? 402 GLN A CD  1 
ATOM 2737 O OE1 . GLN A 1 359 ? 126.315 158.128 124.133 1.00 61.00 ? 402 GLN A OE1 1 
ATOM 2738 N NE2 . GLN A 1 359 ? 128.142 158.837 123.037 1.00 61.44 ? 402 GLN A NE2 1 
ATOM 2739 N N   . HIS A 1 360 ? 127.829 154.621 128.465 1.00 41.27 ? 403 HIS A N   1 
ATOM 2740 C CA  . HIS A 1 360 ? 127.031 154.023 129.536 1.00 51.36 ? 403 HIS A CA  1 
ATOM 2741 C C   . HIS A 1 360 ? 127.720 152.788 130.105 1.00 56.87 ? 403 HIS A C   1 
ATOM 2742 O O   . HIS A 1 360 ? 127.348 151.652 129.781 1.00 62.75 ? 403 HIS A O   1 
ATOM 2743 C CB  . HIS A 1 360 ? 125.632 153.676 129.033 1.00 56.56 ? 403 HIS A CB  1 
ATOM 2744 C CG  . HIS A 1 360 ? 124.798 154.870 128.691 1.00 54.83 ? 403 HIS A CG  1 
ATOM 2745 N ND1 . HIS A 1 360 ? 123.685 155.231 129.418 1.00 54.04 ? 403 HIS A ND1 1 
ATOM 2746 C CD2 . HIS A 1 360 ? 124.912 155.783 127.698 1.00 54.37 ? 403 HIS A CD2 1 
ATOM 2747 C CE1 . HIS A 1 360 ? 123.151 156.318 128.890 1.00 57.85 ? 403 HIS A CE1 1 
ATOM 2748 N NE2 . HIS A 1 360 ? 123.876 156.673 127.845 1.00 56.14 ? 403 HIS A NE2 1 
ATOM 2749 N N   . PRO A 1 361 ? 128.735 152.972 130.955 1.00 50.09 ? 404 PRO A N   1 
ATOM 2750 C CA  . PRO A 1 361 ? 129.358 151.808 131.608 1.00 48.29 ? 404 PRO A CA  1 
ATOM 2751 C C   . PRO A 1 361 ? 128.423 151.030 132.519 1.00 43.26 ? 404 PRO A C   1 
ATOM 2752 O O   . PRO A 1 361 ? 128.723 149.874 132.840 1.00 47.00 ? 404 PRO A O   1 
ATOM 2753 C CB  . PRO A 1 361 ? 130.505 152.426 132.419 1.00 48.09 ? 404 PRO A CB  1 
ATOM 2754 C CG  . PRO A 1 361 ? 130.763 153.753 131.832 1.00 50.93 ? 404 PRO A CG  1 
ATOM 2755 C CD  . PRO A 1 361 ? 129.625 154.146 130.943 1.00 52.78 ? 404 PRO A CD  1 
ATOM 2756 N N   . GLU A 1 362 ? 127.310 151.618 132.952 1.00 50.71 ? 405 GLU A N   1 
ATOM 2757 C CA  . GLU A 1 362 ? 126.553 151.086 134.079 1.00 54.09 ? 405 GLU A CA  1 
ATOM 2758 C C   . GLU A 1 362 ? 125.588 149.964 133.711 1.00 51.93 ? 405 GLU A C   1 
ATOM 2759 O O   . GLU A 1 362 ? 124.942 149.418 134.610 1.00 49.43 ? 405 GLU A O   1 
ATOM 2760 C CB  . GLU A 1 362 ? 125.783 152.217 134.767 1.00 50.94 ? 405 GLU A CB  1 
ATOM 2761 C CG  . GLU A 1 362 ? 124.834 152.972 133.854 1.00 57.97 ? 405 GLU A CG  1 
ATOM 2762 C CD  . GLU A 1 362 ? 125.398 154.302 133.398 1.00 60.95 ? 405 GLU A CD  1 
ATOM 2763 O OE1 . GLU A 1 362 ? 126.591 154.563 133.656 1.00 63.00 ? 405 GLU A OE1 1 
ATOM 2764 O OE2 . GLU A 1 362 ? 124.647 155.087 132.782 1.00 59.63 ? 405 GLU A OE2 1 
ATOM 2765 N N   . TYR A 1 363 ? 125.462 149.600 132.437 1.00 49.73 ? 406 TYR A N   1 
ATOM 2766 C CA  . TYR A 1 363 ? 124.600 148.487 132.061 1.00 49.06 ? 406 TYR A CA  1 
ATOM 2767 C C   . TYR A 1 363 ? 125.332 147.154 131.980 1.00 56.63 ? 406 TYR A C   1 
ATOM 2768 O O   . TYR A 1 363 ? 124.699 146.139 131.674 1.00 61.29 ? 406 TYR A O   1 
ATOM 2769 C CB  . TYR A 1 363 ? 123.907 148.752 130.717 1.00 53.06 ? 406 TYR A CB  1 
ATOM 2770 C CG  . TYR A 1 363 ? 123.265 150.112 130.572 1.00 57.72 ? 406 TYR A CG  1 
ATOM 2771 C CD1 . TYR A 1 363 ? 122.502 150.654 131.596 1.00 58.69 ? 406 TYR A CD1 1 
ATOM 2772 C CD2 . TYR A 1 363 ? 123.368 150.825 129.386 1.00 53.76 ? 406 TYR A CD2 1 
ATOM 2773 C CE1 . TYR A 1 363 ? 121.898 151.889 131.459 1.00 56.77 ? 406 TYR A CE1 1 
ATOM 2774 C CE2 . TYR A 1 363 ? 122.759 152.053 129.237 1.00 53.32 ? 406 TYR A CE2 1 
ATOM 2775 C CZ  . TYR A 1 363 ? 122.031 152.583 130.276 1.00 56.29 ? 406 TYR A CZ  1 
ATOM 2776 O OH  . TYR A 1 363 ? 121.428 153.810 130.130 1.00 54.70 ? 406 TYR A OH  1 
ATOM 2777 N N   . PHE A 1 364 ? 126.631 147.122 132.250 1.00 54.71 ? 407 PHE A N   1 
ATOM 2778 C CA  . PHE A 1 364 ? 127.433 145.926 132.041 1.00 47.31 ? 407 PHE A CA  1 
ATOM 2779 C C   . PHE A 1 364 ? 127.673 145.180 133.351 1.00 54.00 ? 407 PHE A C   1 
ATOM 2780 O O   . PHE A 1 364 ? 127.436 145.690 134.448 1.00 58.55 ? 407 PHE A O   1 
ATOM 2781 C CB  . PHE A 1 364 ? 128.763 146.287 131.379 1.00 44.85 ? 407 PHE A CB  1 
ATOM 2782 C CG  . PHE A 1 364 ? 128.617 146.823 129.986 1.00 40.26 ? 407 PHE A CG  1 
ATOM 2783 C CD1 . PHE A 1 364 ? 128.439 148.176 129.766 1.00 41.84 ? 407 PHE A CD1 1 
ATOM 2784 C CD2 . PHE A 1 364 ? 128.656 145.974 128.898 1.00 44.67 ? 407 PHE A CD2 1 
ATOM 2785 C CE1 . PHE A 1 364 ? 128.304 148.669 128.488 1.00 43.27 ? 407 PHE A CE1 1 
ATOM 2786 C CE2 . PHE A 1 364 ? 128.522 146.462 127.618 1.00 48.69 ? 407 PHE A CE2 1 
ATOM 2787 C CZ  . PHE A 1 364 ? 128.346 147.813 127.413 1.00 46.28 ? 407 PHE A CZ  1 
ATOM 2788 N N   . VAL A 1 365 ? 128.152 143.947 133.212 1.00 47.36 ? 408 VAL A N   1 
ATOM 2789 C CA  . VAL A 1 365 ? 128.410 143.073 134.350 1.00 42.32 ? 408 VAL A CA  1 
ATOM 2790 C C   . VAL A 1 365 ? 129.784 143.385 134.926 1.00 50.96 ? 408 VAL A C   1 
ATOM 2791 O O   . VAL A 1 365 ? 130.761 143.558 134.187 1.00 52.63 ? 408 VAL A O   1 
ATOM 2792 C CB  . VAL A 1 365 ? 128.293 141.597 133.925 1.00 43.17 ? 408 VAL A CB  1 
ATOM 2793 C CG1 . VAL A 1 365 ? 129.162 140.710 134.794 1.00 49.60 ? 408 VAL A CG1 1 
ATOM 2794 C CG2 . VAL A 1 365 ? 126.847 141.144 133.987 1.00 46.87 ? 408 VAL A CG2 1 
ATOM 2795 N N   . MET A 1 366 ? 129.863 143.462 136.252 1.00 60.72 ? 409 MET A N   1 
ATOM 2796 C CA  . MET A 1 366 ? 131.096 143.778 136.960 1.00 56.76 ? 409 MET A CA  1 
ATOM 2797 C C   . MET A 1 366 ? 131.644 142.523 137.626 1.00 59.39 ? 409 MET A C   1 
ATOM 2798 O O   . MET A 1 366 ? 130.899 141.790 138.285 1.00 58.75 ? 409 MET A O   1 
ATOM 2799 C CB  . MET A 1 366 ? 130.859 144.869 138.005 1.00 58.12 ? 409 MET A CB  1 
ATOM 2800 C CG  . MET A 1 366 ? 132.120 145.577 138.464 1.00 58.22 ? 409 MET A CG  1 
ATOM 2801 S SD  . MET A 1 366 ? 131.763 147.058 139.424 1.00 67.98 ? 409 MET A SD  1 
ATOM 2802 C CE  . MET A 1 366 ? 131.732 148.297 138.133 1.00 61.73 ? 409 MET A CE  1 
ATOM 2803 N N   . ASP A 1 367 ? 132.942 142.286 137.459 1.00 71.72 ? 410 ASP A N   1 
ATOM 2804 C CA  . ASP A 1 367 ? 133.599 141.117 138.029 1.00 67.69 ? 410 ASP A CA  1 
ATOM 2805 C C   . ASP A 1 367 ? 133.885 141.356 139.512 1.00 67.81 ? 410 ASP A C   1 
ATOM 2806 O O   . ASP A 1 367 ? 133.489 142.370 140.094 1.00 74.06 ? 410 ASP A O   1 
ATOM 2807 C CB  . ASP A 1 367 ? 134.870 140.794 137.249 1.00 66.70 ? 410 ASP A CB  1 
ATOM 2808 C CG  . ASP A 1 367 ? 135.135 139.305 137.157 1.00 73.22 ? 410 ASP A CG  1 
ATOM 2809 O OD1 . ASP A 1 367 ? 134.245 138.517 137.539 1.00 74.04 ? 410 ASP A OD1 1 
ATOM 2810 O OD2 . ASP A 1 367 ? 136.234 138.923 136.703 1.00 74.96 ? 410 ASP A OD2 1 
ATOM 2811 N N   . ALA A 1 368 ? 134.587 140.411 140.142 1.00 55.78 ? 411 ALA A N   1 
ATOM 2812 C CA  . ALA A 1 368 ? 134.857 140.512 141.573 1.00 55.48 ? 411 ALA A CA  1 
ATOM 2813 C C   . ALA A 1 368 ? 135.820 141.649 141.884 1.00 58.82 ? 411 ALA A C   1 
ATOM 2814 O O   . ALA A 1 368 ? 135.683 142.321 142.913 1.00 64.42 ? 411 ALA A O   1 
ATOM 2815 C CB  . ALA A 1 368 ? 135.406 139.186 142.097 1.00 61.28 ? 411 ALA A CB  1 
ATOM 2816 N N   . ASP A 1 369 ? 136.799 141.881 141.013 1.00 68.13 ? 412 ASP A N   1 
ATOM 2817 C CA  . ASP A 1 369 ? 137.813 142.899 141.253 1.00 68.60 ? 412 ASP A CA  1 
ATOM 2818 C C   . ASP A 1 369 ? 137.364 144.298 140.853 1.00 71.11 ? 412 ASP A C   1 
ATOM 2819 O O   . ASP A 1 369 ? 138.132 145.249 141.030 1.00 74.65 ? 412 ASP A O   1 
ATOM 2820 C CB  . ASP A 1 369 ? 139.102 142.541 140.510 1.00 71.61 ? 412 ASP A CB  1 
ATOM 2821 C CG  . ASP A 1 369 ? 138.840 141.928 139.149 1.00 76.52 ? 412 ASP A CG  1 
ATOM 2822 O OD1 . ASP A 1 369 ? 137.659 141.843 138.751 1.00 76.63 ? 412 ASP A OD1 1 
ATOM 2823 O OD2 . ASP A 1 369 ? 139.814 141.530 138.477 1.00 75.83 ? 412 ASP A OD2 1 
ATOM 2824 N N   . GLY A 1 370 ? 136.154 144.449 140.321 1.00 65.20 ? 413 GLY A N   1 
ATOM 2825 C CA  . GLY A 1 370 ? 135.673 145.752 139.912 1.00 67.23 ? 413 GLY A CA  1 
ATOM 2826 C C   . GLY A 1 370 ? 136.022 146.080 138.476 1.00 65.92 ? 413 GLY A C   1 
ATOM 2827 O O   . GLY A 1 370 ? 136.325 147.231 138.147 1.00 68.69 ? 413 GLY A O   1 
ATOM 2828 N N   . ARG A 1 371 ? 135.981 145.072 137.613 1.00 56.93 ? 414 ARG A N   1 
ATOM 2829 C CA  . ARG A 1 371 ? 136.298 145.216 136.204 1.00 56.88 ? 414 ARG A CA  1 
ATOM 2830 C C   . ARG A 1 371 ? 135.199 144.583 135.366 1.00 62.13 ? 414 ARG A C   1 
ATOM 2831 O O   . ARG A 1 371 ? 134.524 143.656 135.822 1.00 66.22 ? 414 ARG A O   1 
ATOM 2832 C CB  . ARG A 1 371 ? 137.646 144.559 135.875 1.00 58.27 ? 414 ARG A CB  1 
ATOM 2833 C CG  . ARG A 1 371 ? 138.805 145.537 135.787 1.00 62.56 ? 414 ARG A CG  1 
ATOM 2834 C CD  . ARG A 1 371 ? 139.993 144.924 135.067 1.00 61.54 ? 414 ARG A CD  1 
ATOM 2835 N NE  . ARG A 1 371 ? 140.390 143.651 135.657 1.00 62.93 ? 414 ARG A NE  1 
ATOM 2836 C CZ  . ARG A 1 371 ? 141.332 143.515 136.580 1.00 68.20 ? 414 ARG A CZ  1 
ATOM 2837 N NH1 . ARG A 1 371 ? 141.999 144.558 137.045 1.00 66.92 ? 414 ARG A NH1 1 
ATOM 2838 N NH2 . ARG A 1 371 ? 141.612 142.302 137.047 1.00 68.83 ? 414 ARG A NH2 1 
ATOM 2839 N N   . PRO A 1 372 ? 134.986 145.073 134.145 1.00 48.58 ? 415 PRO A N   1 
ATOM 2840 C CA  . PRO A 1 372 ? 133.951 144.480 133.291 1.00 44.34 ? 415 PRO A CA  1 
ATOM 2841 C C   . PRO A 1 372 ? 134.285 143.042 132.926 1.00 51.75 ? 415 PRO A C   1 
ATOM 2842 O O   . PRO A 1 372 ? 135.450 142.669 132.773 1.00 56.16 ? 415 PRO A O   1 
ATOM 2843 C CB  . PRO A 1 372 ? 133.946 145.388 132.056 1.00 45.05 ? 415 PRO A CB  1 
ATOM 2844 C CG  . PRO A 1 372 ? 135.282 146.042 132.059 1.00 45.56 ? 415 PRO A CG  1 
ATOM 2845 C CD  . PRO A 1 372 ? 135.649 146.215 133.496 1.00 49.98 ? 415 PRO A CD  1 
ATOM 2846 N N   . ALA A 1 373 ? 133.241 142.233 132.784 1.00 49.51 ? 416 ALA A N   1 
ATOM 2847 C CA  . ALA A 1 373 ? 133.378 140.821 132.469 1.00 48.09 ? 416 ALA A CA  1 
ATOM 2848 C C   . ALA A 1 373 ? 133.065 140.569 131.000 1.00 48.62 ? 416 ALA A C   1 
ATOM 2849 O O   . ALA A 1 373 ? 132.332 141.329 130.362 1.00 54.66 ? 416 ALA A O   1 
ATOM 2850 C CB  . ALA A 1 373 ? 132.459 139.973 133.349 1.00 46.25 ? 416 ALA A CB  1 
ATOM 2851 N N   . ARG A 1 374 ? 133.626 139.486 130.470 1.00 48.17 ? 417 ARG A N   1 
ATOM 2852 C CA  . ARG A 1 374 ? 133.455 139.113 129.075 1.00 42.67 ? 417 ARG A CA  1 
ATOM 2853 C C   . ARG A 1 374 ? 132.724 137.781 128.979 1.00 47.46 ? 417 ARG A C   1 
ATOM 2854 O O   . ARG A 1 374 ? 132.801 136.945 129.884 1.00 54.51 ? 417 ARG A O   1 
ATOM 2855 C CB  . ARG A 1 374 ? 134.805 139.026 128.355 1.00 40.02 ? 417 ARG A CB  1 
ATOM 2856 C CG  . ARG A 1 374 ? 135.413 140.378 128.036 1.00 46.41 ? 417 ARG A CG  1 
ATOM 2857 C CD  . ARG A 1 374 ? 136.703 140.243 127.251 1.00 46.17 ? 417 ARG A CD  1 
ATOM 2858 N NE  . ARG A 1 374 ? 136.482 139.658 125.935 1.00 47.07 ? 417 ARG A NE  1 
ATOM 2859 C CZ  . ARG A 1 374 ? 137.369 139.675 124.950 1.00 48.76 ? 417 ARG A CZ  1 
ATOM 2860 N NH1 . ARG A 1 374 ? 138.552 140.248 125.096 1.00 46.51 ? 417 ARG A NH1 1 
ATOM 2861 N NH2 . ARG A 1 374 ? 137.060 139.106 123.789 1.00 50.55 ? 417 ARG A NH2 1 
ATOM 2862 N N   . LEU A 1 375 ? 132.011 137.599 127.876 1.00 46.99 ? 418 LEU A N   1 
ATOM 2863 C CA  . LEU A 1 375 ? 131.212 136.395 127.688 1.00 45.11 ? 418 LEU A CA  1 
ATOM 2864 C C   . LEU A 1 375 ? 132.121 135.174 127.601 1.00 49.94 ? 418 LEU A C   1 
ATOM 2865 O O   . LEU A 1 375 ? 133.106 135.193 126.854 1.00 56.77 ? 418 LEU A O   1 
ATOM 2866 C CB  . LEU A 1 375 ? 130.365 136.517 126.425 1.00 49.62 ? 418 LEU A CB  1 
ATOM 2867 C CG  . LEU A 1 375 ? 129.151 137.444 126.513 1.00 54.82 ? 418 LEU A CG  1 
ATOM 2868 C CD1 . LEU A 1 375 ? 128.559 137.686 125.134 1.00 51.99 ? 418 LEU A CD1 1 
ATOM 2869 C CD2 . LEU A 1 375 ? 128.105 136.880 127.454 1.00 48.73 ? 418 LEU A CD2 1 
ATOM 2870 N N   . PRO A 1 376 ? 131.832 134.102 128.338 1.00 45.99 ? 419 PRO A N   1 
ATOM 2871 C CA  . PRO A 1 376 ? 132.729 132.943 128.350 1.00 44.65 ? 419 PRO A CA  1 
ATOM 2872 C C   . PRO A 1 376 ? 132.397 131.908 127.287 1.00 48.38 ? 419 PRO A C   1 
ATOM 2873 O O   . PRO A 1 376 ? 131.236 131.586 127.026 1.00 53.11 ? 419 PRO A O   1 
ATOM 2874 C CB  . PRO A 1 376 ? 132.505 132.366 129.753 1.00 45.96 ? 419 PRO A CB  1 
ATOM 2875 C CG  . PRO A 1 376 ? 131.076 132.681 130.046 1.00 43.84 ? 419 PRO A CG  1 
ATOM 2876 C CD  . PRO A 1 376 ? 130.731 133.955 129.305 1.00 46.12 ? 419 PRO A CD  1 
ATOM 2877 N N   . THR A 1 377 ? 133.450 131.381 126.665 1.00 48.61 ? 420 THR A N   1 
ATOM 2878 C CA  . THR A 1 377 ? 133.312 130.228 125.795 1.00 42.59 ? 420 THR A CA  1 
ATOM 2879 C C   . THR A 1 377 ? 133.058 128.983 126.642 1.00 47.87 ? 420 THR A C   1 
ATOM 2880 O O   . THR A 1 377 ? 133.344 128.974 127.841 1.00 52.85 ? 420 THR A O   1 
ATOM 2881 C CB  . THR A 1 377 ? 134.566 130.050 124.944 1.00 46.42 ? 420 THR A CB  1 
ATOM 2882 O OG1 . THR A 1 377 ? 135.693 129.807 125.793 1.00 53.58 ? 420 THR A OG1 1 
ATOM 2883 C CG2 . THR A 1 377 ? 134.824 131.293 124.110 1.00 51.11 ? 420 THR A CG2 1 
ATOM 2884 N N   . PRO A 1 378 ? 132.497 127.927 126.050 1.00 42.85 ? 421 PRO A N   1 
ATOM 2885 C CA  . PRO A 1 378 ? 132.229 126.710 126.829 1.00 41.08 ? 421 PRO A CA  1 
ATOM 2886 C C   . PRO A 1 378 ? 133.496 126.174 127.478 1.00 47.16 ? 421 PRO A C   1 
ATOM 2887 O O   . PRO A 1 378 ? 134.479 125.862 126.804 1.00 53.28 ? 421 PRO A O   1 
ATOM 2888 C CB  . PRO A 1 378 ? 131.671 125.738 125.784 1.00 45.69 ? 421 PRO A CB  1 
ATOM 2889 C CG  . PRO A 1 378 ? 131.086 126.613 124.742 1.00 51.10 ? 421 PRO A CG  1 
ATOM 2890 C CD  . PRO A 1 378 ? 131.962 127.827 124.680 1.00 47.76 ? 421 PRO A CD  1 
ATOM 2891 N N   . GLY A 1 379 ? 133.461 126.069 128.803 1.00 41.44 ? 422 GLY A N   1 
ATOM 2892 C CA  . GLY A 1 379 ? 134.620 125.649 129.563 1.00 39.38 ? 422 GLY A CA  1 
ATOM 2893 C C   . GLY A 1 379 ? 135.157 126.734 130.473 1.00 42.35 ? 422 GLY A C   1 
ATOM 2894 O O   . GLY A 1 379 ? 135.547 126.458 131.610 1.00 51.43 ? 422 GLY A O   1 
ATOM 2895 N N   . GLY A 1 380 ? 135.181 127.974 129.987 1.00 48.35 ? 423 GLY A N   1 
ATOM 2896 C CA  . GLY A 1 380 ? 135.630 129.085 130.802 1.00 54.90 ? 423 GLY A CA  1 
ATOM 2897 C C   . GLY A 1 380 ? 136.641 129.994 130.134 1.00 54.31 ? 423 GLY A C   1 
ATOM 2898 O O   . GLY A 1 380 ? 137.233 130.856 130.789 1.00 58.59 ? 423 GLY A O   1 
ATOM 2899 N N   . GLY A 1 381 ? 136.850 129.815 128.832 1.00 44.71 ? 424 GLY A N   1 
ATOM 2900 C CA  . GLY A 1 381 ? 137.798 130.614 128.088 1.00 47.17 ? 424 GLY A CA  1 
ATOM 2901 C C   . GLY A 1 381 ? 137.199 131.919 127.598 1.00 49.03 ? 424 GLY A C   1 
ATOM 2902 O O   . GLY A 1 381 ? 136.104 132.327 127.988 1.00 51.24 ? 424 GLY A O   1 
ATOM 2903 N N   . THR A 1 382 ? 137.949 132.584 126.722 1.00 51.10 ? 425 THR A N   1 
ATOM 2904 C CA  . THR A 1 382 ? 137.533 133.845 126.128 1.00 51.73 ? 425 THR A CA  1 
ATOM 2905 C C   . THR A 1 382 ? 137.959 133.881 124.666 1.00 52.36 ? 425 THR A C   1 
ATOM 2906 O O   . THR A 1 382 ? 139.075 133.487 124.318 1.00 55.84 ? 425 THR A O   1 
ATOM 2907 C CB  . THR A 1 382 ? 138.131 135.043 126.889 1.00 55.51 ? 425 THR A CB  1 
ATOM 2908 O OG1 . THR A 1 382 ? 137.538 135.126 128.191 1.00 58.91 ? 425 THR A OG1 1 
ATOM 2909 C CG2 . THR A 1 382 ? 137.878 136.346 126.145 1.00 54.37 ? 425 THR A CG2 1 
ATOM 2910 N N   . ASN A 1 383 ? 137.056 134.357 123.812 1.00 50.69 ? 426 ASN A N   1 
ATOM 2911 C CA  . ASN A 1 383 ? 137.295 134.466 122.385 1.00 48.14 ? 426 ASN A CA  1 
ATOM 2912 C C   . ASN A 1 383 ? 137.436 135.935 122.010 1.00 50.68 ? 426 ASN A C   1 
ATOM 2913 O O   . ASN A 1 383 ? 136.717 136.778 122.565 1.00 58.58 ? 426 ASN A O   1 
ATOM 2914 C CB  . ASN A 1 383 ? 136.138 133.831 121.593 1.00 52.75 ? 426 ASN A CB  1 
ATOM 2915 C CG  . ASN A 1 383 ? 136.544 133.406 120.197 1.00 55.85 ? 426 ASN A CG  1 
ATOM 2916 O OD1 . ASN A 1 383 ? 135.782 133.562 119.244 1.00 58.88 ? 426 ASN A OD1 1 
ATOM 2917 N ND2 . ASN A 1 383 ? 137.735 132.834 120.074 1.00 56.44 ? 426 ASN A ND2 1 
ATOM 2918 N N   . PRO A 1 384 ? 138.346 136.288 121.098 1.00 39.77 ? 427 PRO A N   1 
ATOM 2919 C CA  . PRO A 1 384 ? 138.475 137.702 120.708 1.00 41.78 ? 427 PRO A CA  1 
ATOM 2920 C C   . PRO A 1 384 ? 137.202 138.296 120.134 1.00 52.19 ? 427 PRO A C   1 
ATOM 2921 O O   . PRO A 1 384 ? 136.963 139.499 120.302 1.00 56.32 ? 427 PRO A O   1 
ATOM 2922 C CB  . PRO A 1 384 ? 139.600 137.673 119.667 1.00 46.07 ? 427 PRO A CB  1 
ATOM 2923 C CG  . PRO A 1 384 ? 140.408 136.485 120.025 1.00 48.40 ? 427 PRO A CG  1 
ATOM 2924 C CD  . PRO A 1 384 ? 139.445 135.466 120.564 1.00 47.31 ? 427 PRO A CD  1 
ATOM 2925 N N   . SER A 1 385 ? 136.382 137.494 119.452 1.00 53.16 ? 428 SER A N   1 
ATOM 2926 C CA  . SER A 1 385 ? 135.156 138.017 118.858 1.00 54.38 ? 428 SER A CA  1 
ATOM 2927 C C   . SER A 1 385 ? 134.175 138.491 119.923 1.00 48.73 ? 428 SER A C   1 
ATOM 2928 O O   . SER A 1 385 ? 133.530 139.533 119.761 1.00 56.51 ? 428 SER A O   1 
ATOM 2929 C CB  . SER A 1 385 ? 134.511 136.955 117.969 1.00 53.57 ? 428 SER A CB  1 
ATOM 2930 O OG  . SER A 1 385 ? 135.232 136.797 116.760 1.00 56.49 ? 428 SER A OG  1 
ATOM 2931 N N   . LEU A 1 386 ? 134.047 137.743 121.015 1.00 37.89 ? 429 LEU A N   1 
ATOM 2932 C CA  . LEU A 1 386 ? 133.081 138.079 122.047 1.00 39.48 ? 429 LEU A CA  1 
ATOM 2933 C C   . LEU A 1 386 ? 133.502 139.339 122.801 1.00 51.04 ? 429 LEU A C   1 
ATOM 2934 O O   . LEU A 1 386 ? 134.683 139.690 122.877 1.00 56.34 ? 429 LEU A O   1 
ATOM 2935 C CB  . LEU A 1 386 ? 132.917 136.914 123.022 1.00 42.84 ? 429 LEU A CB  1 
ATOM 2936 C CG  . LEU A 1 386 ? 132.118 135.720 122.504 1.00 45.71 ? 429 LEU A CG  1 
ATOM 2937 C CD1 . LEU A 1 386 ? 132.318 134.514 123.403 1.00 48.62 ? 429 LEU A CD1 1 
ATOM 2938 C CD2 . LEU A 1 386 ? 130.645 136.072 122.397 1.00 50.29 ? 429 LEU A CD2 1 
ATOM 2939 N N   . GLY A 1 387 ? 132.508 140.024 123.363 1.00 55.33 ? 430 GLY A N   1 
ATOM 2940 C CA  . GLY A 1 387 ? 132.745 141.249 124.100 1.00 47.07 ? 430 GLY A CA  1 
ATOM 2941 C C   . GLY A 1 387 ? 132.150 141.234 125.493 1.00 48.85 ? 430 GLY A C   1 
ATOM 2942 O O   . GLY A 1 387 ? 131.830 140.166 126.023 1.00 52.87 ? 430 GLY A O   1 
ATOM 2943 N N   . TYR A 1 388 ? 132.000 142.411 126.097 1.00 43.25 ? 431 TYR A N   1 
ATOM 2944 C CA  . TYR A 1 388 ? 131.461 142.497 127.447 1.00 37.46 ? 431 TYR A CA  1 
ATOM 2945 C C   . TYR A 1 388 ? 129.996 142.081 127.475 1.00 36.94 ? 431 TYR A C   1 
ATOM 2946 O O   . TYR A 1 388 ? 129.230 142.349 126.546 1.00 47.94 ? 431 TYR A O   1 
ATOM 2947 C CB  . TYR A 1 388 ? 131.604 143.915 127.998 1.00 40.32 ? 431 TYR A CB  1 
ATOM 2948 C CG  . TYR A 1 388 ? 133.031 144.383 128.153 1.00 43.26 ? 431 TYR A CG  1 
ATOM 2949 C CD1 . TYR A 1 388 ? 133.959 143.625 128.849 1.00 43.68 ? 431 TYR A CD1 1 
ATOM 2950 C CD2 . TYR A 1 388 ? 133.446 145.589 127.610 1.00 48.53 ? 431 TYR A CD2 1 
ATOM 2951 C CE1 . TYR A 1 388 ? 135.263 144.053 128.993 1.00 44.20 ? 431 TYR A CE1 1 
ATOM 2952 C CE2 . TYR A 1 388 ? 134.746 146.024 127.750 1.00 45.20 ? 431 TYR A CE2 1 
ATOM 2953 C CZ  . TYR A 1 388 ? 135.650 145.253 128.441 1.00 43.10 ? 431 TYR A CZ  1 
ATOM 2954 O OH  . TYR A 1 388 ? 136.948 145.686 128.581 1.00 46.06 ? 431 TYR A OH  1 
ATOM 2955 N N   . ALA A 1 389 ? 129.611 141.418 128.559 1.00 36.64 ? 432 ALA A N   1 
ATOM 2956 C CA  . ALA A 1 389 ? 128.235 140.996 128.740 1.00 41.71 ? 432 ALA A CA  1 
ATOM 2957 C C   . ALA A 1 389 ? 127.386 142.154 129.252 1.00 49.52 ? 432 ALA A C   1 
ATOM 2958 O O   . ALA A 1 389 ? 127.884 143.104 129.860 1.00 55.81 ? 432 ALA A O   1 
ATOM 2959 C CB  . ALA A 1 389 ? 128.156 139.817 129.710 1.00 48.78 ? 432 ALA A CB  1 
ATOM 2960 N N   . LEU A 1 390 ? 126.085 142.063 128.998 1.00 45.48 ? 433 LEU A N   1 
ATOM 2961 C CA  . LEU A 1 390 ? 125.129 143.073 129.428 1.00 38.47 ? 433 LEU A CA  1 
ATOM 2962 C C   . LEU A 1 390 ? 124.278 142.499 130.550 1.00 42.73 ? 433 LEU A C   1 
ATOM 2963 O O   . LEU A 1 390 ? 123.694 141.421 130.401 1.00 52.02 ? 433 LEU A O   1 
ATOM 2964 C CB  . LEU A 1 390 ? 124.246 143.527 128.265 1.00 42.68 ? 433 LEU A CB  1 
ATOM 2965 C CG  . LEU A 1 390 ? 124.742 144.755 127.496 1.00 45.79 ? 433 LEU A CG  1 
ATOM 2966 C CD1 . LEU A 1 390 ? 124.104 144.819 126.117 1.00 45.45 ? 433 LEU A CD1 1 
ATOM 2967 C CD2 . LEU A 1 390 ? 124.500 146.040 128.271 1.00 48.71 ? 433 LEU A CD2 1 
ATOM 2968 N N   . CYS A 1 391 ? 124.213 143.213 131.663 1.00 44.77 ? 434 CYS A N   1 
ATOM 2969 C CA  . CYS A 1 391 ? 123.503 142.716 132.834 1.00 38.32 ? 434 CYS A CA  1 
ATOM 2970 C C   . CYS A 1 391 ? 122.003 142.732 132.577 1.00 45.82 ? 434 CYS A C   1 
ATOM 2971 O O   . CYS A 1 391 ? 121.451 143.788 132.242 1.00 50.93 ? 434 CYS A O   1 
ATOM 2972 C CB  . CYS A 1 391 ? 123.848 143.557 134.058 1.00 40.33 ? 434 CYS A CB  1 
ATOM 2973 S SG  . CYS A 1 391 ? 123.260 142.870 135.619 1.00 54.77 ? 434 CYS A SG  1 
ATOM 2974 N N   . PRO A 1 392 ? 121.309 141.599 132.712 1.00 32.71 ? 435 PRO A N   1 
ATOM 2975 C CA  . PRO A 1 392 ? 119.872 141.570 132.398 1.00 30.48 ? 435 PRO A CA  1 
ATOM 2976 C C   . PRO A 1 392 ? 119.016 142.431 133.307 1.00 42.36 ? 435 PRO A C   1 
ATOM 2977 O O   . PRO A 1 392 ? 117.892 142.774 132.920 1.00 51.10 ? 435 PRO A O   1 
ATOM 2978 C CB  . PRO A 1 392 ? 119.511 140.087 132.548 1.00 42.19 ? 435 PRO A CB  1 
ATOM 2979 C CG  . PRO A 1 392 ? 120.813 139.362 132.423 1.00 45.25 ? 435 PRO A CG  1 
ATOM 2980 C CD  . PRO A 1 392 ? 121.826 140.263 133.044 1.00 43.56 ? 435 PRO A CD  1 
ATOM 2981 N N   . MET A 1 393 ? 119.494 142.790 134.495 1.00 45.14 ? 436 MET A N   1 
ATOM 2982 C CA  . MET A 1 393 ? 118.710 143.576 135.437 1.00 40.42 ? 436 MET A CA  1 
ATOM 2983 C C   . MET A 1 393 ? 118.949 145.072 135.294 1.00 47.92 ? 436 MET A C   1 
ATOM 2984 O O   . MET A 1 393 ? 118.497 145.846 136.143 1.00 54.82 ? 436 MET A O   1 
ATOM 2985 C CB  . MET A 1 393 ? 118.999 143.130 136.870 1.00 41.93 ? 436 MET A CB  1 
ATOM 2986 C CG  . MET A 1 393 ? 119.000 141.626 137.058 1.00 45.95 ? 436 MET A CG  1 
ATOM 2987 S SD  . MET A 1 393 ? 118.068 141.124 138.514 1.00 63.91 ? 436 MET A SD  1 
ATOM 2988 C CE  . MET A 1 393 ? 118.967 141.981 139.803 1.00 47.54 ? 436 MET A CE  1 
ATOM 2989 N N   . ALA A 1 394 ? 119.646 145.495 134.245 1.00 56.44 ? 437 ALA A N   1 
ATOM 2990 C CA  . ALA A 1 394 ? 119.811 146.906 133.927 1.00 52.83 ? 437 ALA A CA  1 
ATOM 2991 C C   . ALA A 1 394 ? 118.875 147.264 132.781 1.00 61.21 ? 437 ALA A C   1 
ATOM 2992 O O   . ALA A 1 394 ? 118.832 146.560 131.766 1.00 64.61 ? 437 ALA A O   1 
ATOM 2993 C CB  . ALA A 1 394 ? 121.259 147.220 133.553 1.00 54.69 ? 437 ALA A CB  1 
ATOM 2994 N N   . ASP A 1 395 ? 118.122 148.355 132.950 1.00 64.97 ? 438 ASP A N   1 
ATOM 2995 C CA  . ASP A 1 395 ? 117.144 148.743 131.938 1.00 65.53 ? 438 ASP A CA  1 
ATOM 2996 C C   . ASP A 1 395 ? 117.810 149.130 130.625 1.00 61.23 ? 438 ASP A C   1 
ATOM 2997 O O   . ASP A 1 395 ? 117.190 149.023 129.559 1.00 62.98 ? 438 ASP A O   1 
ATOM 2998 C CB  . ASP A 1 395 ? 116.286 149.897 132.457 1.00 66.62 ? 438 ASP A CB  1 
ATOM 2999 C CG  . ASP A 1 395 ? 115.472 149.514 133.676 1.00 68.97 ? 438 ASP A CG  1 
ATOM 3000 O OD1 . ASP A 1 395 ? 115.377 148.305 133.975 1.00 66.92 ? 438 ASP A OD1 1 
ATOM 3001 O OD2 . ASP A 1 395 ? 114.926 150.423 134.337 1.00 66.62 ? 438 ASP A OD2 1 
ATOM 3002 N N   . GLY A 1 396 ? 119.064 149.580 130.681 1.00 51.47 ? 439 GLY A N   1 
ATOM 3003 C CA  . GLY A 1 396 ? 119.744 150.006 129.469 1.00 55.20 ? 439 GLY A CA  1 
ATOM 3004 C C   . GLY A 1 396 ? 119.942 148.884 128.470 1.00 58.99 ? 439 GLY A C   1 
ATOM 3005 O O   . GLY A 1 396 ? 119.788 149.084 127.264 1.00 61.45 ? 439 GLY A O   1 
ATOM 3006 N N   . ALA A 1 397 ? 120.295 147.690 128.953 1.00 53.99 ? 440 ALA A N   1 
ATOM 3007 C CA  . ALA A 1 397 ? 120.504 146.561 128.051 1.00 58.62 ? 440 ALA A CA  1 
ATOM 3008 C C   . ALA A 1 397 ? 119.218 146.197 127.319 1.00 60.25 ? 440 ALA A C   1 
ATOM 3009 O O   . ALA A 1 397 ? 119.211 146.019 126.093 1.00 63.86 ? 440 ALA A O   1 
ATOM 3010 C CB  . ALA A 1 397 ? 121.034 145.360 128.834 1.00 57.52 ? 440 ALA A CB  1 
ATOM 3011 N N   . ILE A 1 398 ? 118.117 146.085 128.063 1.00 52.03 ? 441 ILE A N   1 
ATOM 3012 C CA  . ILE A 1 398 ? 116.830 145.750 127.462 1.00 50.40 ? 441 ILE A CA  1 
ATOM 3013 C C   . ILE A 1 398 ? 116.406 146.832 126.478 1.00 55.89 ? 441 ILE A C   1 
ATOM 3014 O O   . ILE A 1 398 ? 115.915 146.539 125.377 1.00 59.35 ? 441 ILE A O   1 
ATOM 3015 C CB  . ILE A 1 398 ? 115.780 145.536 128.568 1.00 55.43 ? 441 ILE A CB  1 
ATOM 3016 C CG1 . ILE A 1 398 ? 116.026 144.204 129.284 1.00 54.61 ? 441 ILE A CG1 1 
ATOM 3017 C CG2 . ILE A 1 398 ? 114.370 145.624 128.010 1.00 58.85 ? 441 ILE A CG2 1 
ATOM 3018 C CD1 . ILE A 1 398 ? 116.377 143.063 128.358 1.00 54.30 ? 441 ILE A CD1 1 
ATOM 3019 N N   . ALA A 1 399 ? 116.591 148.099 126.856 1.00 53.30 ? 442 ALA A N   1 
ATOM 3020 C CA  . ALA A 1 399 ? 116.246 149.197 125.962 1.00 49.52 ? 442 ALA A CA  1 
ATOM 3021 C C   . ALA A 1 399 ? 117.064 149.142 124.680 1.00 46.43 ? 442 ALA A C   1 
ATOM 3022 O O   . ALA A 1 399 ? 116.534 149.378 123.591 1.00 50.33 ? 442 ALA A O   1 
ATOM 3023 C CB  . ALA A 1 399 ? 116.447 150.536 126.672 1.00 52.10 ? 442 ALA A CB  1 
ATOM 3024 N N   . SER A 1 400 ? 118.358 148.832 124.788 1.00 45.02 ? 443 SER A N   1 
ATOM 3025 C CA  . SER A 1 400 ? 119.206 148.753 123.603 1.00 50.58 ? 443 SER A CA  1 
ATOM 3026 C C   . SER A 1 400 ? 118.776 147.615 122.686 1.00 56.25 ? 443 SER A C   1 
ATOM 3027 O O   . SER A 1 400 ? 118.726 147.780 121.459 1.00 59.60 ? 443 SER A O   1 
ATOM 3028 C CB  . SER A 1 400 ? 120.667 148.587 124.018 1.00 48.52 ? 443 SER A CB  1 
ATOM 3029 O OG  . SER A 1 400 ? 121.413 147.939 123.004 1.00 52.51 ? 443 SER A OG  1 
ATOM 3030 N N   . GLN A 1 401 ? 118.461 146.451 123.260 1.00 52.95 ? 444 GLN A N   1 
ATOM 3031 C CA  . GLN A 1 401 ? 118.005 145.332 122.439 1.00 48.50 ? 444 GLN A CA  1 
ATOM 3032 C C   . GLN A 1 401 ? 116.701 145.668 121.723 1.00 54.78 ? 444 GLN A C   1 
ATOM 3033 O O   . GLN A 1 401 ? 116.551 145.396 120.523 1.00 56.42 ? 444 GLN A O   1 
ATOM 3034 C CB  . GLN A 1 401 ? 117.836 144.078 123.296 1.00 50.80 ? 444 GLN A CB  1 
ATOM 3035 C CG  . GLN A 1 401 ? 119.062 143.698 124.106 1.00 53.56 ? 444 GLN A CG  1 
ATOM 3036 C CD  . GLN A 1 401 ? 119.996 142.771 123.363 1.00 55.85 ? 444 GLN A CD  1 
ATOM 3037 O OE1 . GLN A 1 401 ? 119.594 141.699 122.911 1.00 61.52 ? 444 GLN A OE1 1 
ATOM 3038 N NE2 . GLN A 1 401 ? 121.252 143.177 123.232 1.00 53.13 ? 444 GLN A NE2 1 
ATOM 3039 N N   . VAL A 1 402 ? 115.751 146.274 122.440 1.00 49.59 ? 445 VAL A N   1 
ATOM 3040 C CA  . VAL A 1 402 ? 114.478 146.639 121.825 1.00 42.17 ? 445 VAL A CA  1 
ATOM 3041 C C   . VAL A 1 402 ? 114.685 147.694 120.745 1.00 48.45 ? 445 VAL A C   1 
ATOM 3042 O O   . VAL A 1 402 ? 114.044 147.653 119.688 1.00 55.20 ? 445 VAL A O   1 
ATOM 3043 C CB  . VAL A 1 402 ? 113.486 147.111 122.903 1.00 44.64 ? 445 VAL A CB  1 
ATOM 3044 C CG1 . VAL A 1 402 ? 112.301 147.824 122.273 1.00 52.65 ? 445 VAL A CG1 1 
ATOM 3045 C CG2 . VAL A 1 402 ? 113.016 145.934 123.726 1.00 44.96 ? 445 VAL A CG2 1 
ATOM 3046 N N   . ASP A 1 403 ? 115.576 148.657 120.994 1.00 49.97 ? 446 ASP A N   1 
ATOM 3047 C CA  . ASP A 1 403 ? 115.857 149.692 120.007 1.00 49.51 ? 446 ASP A CA  1 
ATOM 3048 C C   . ASP A 1 403 ? 116.426 149.074 118.737 1.00 50.44 ? 446 ASP A C   1 
ATOM 3049 O O   . ASP A 1 403 ? 116.003 149.420 117.628 1.00 52.90 ? 446 ASP A O   1 
ATOM 3050 C CB  . ASP A 1 403 ? 116.821 150.719 120.617 1.00 49.23 ? 446 ASP A CB  1 
ATOM 3051 C CG  . ASP A 1 403 ? 117.259 151.812 119.639 1.00 52.31 ? 446 ASP A CG  1 
ATOM 3052 O OD1 . ASP A 1 403 ? 117.953 152.745 120.096 1.00 54.39 ? 446 ASP A OD1 1 
ATOM 3053 O OD2 . ASP A 1 403 ? 116.896 151.788 118.446 1.00 53.45 ? 446 ASP A OD2 1 
ATOM 3054 N N   . PHE A 1 404 ? 117.370 148.140 118.879 1.00 47.33 ? 447 PHE A N   1 
ATOM 3055 C CA  . PHE A 1 404 ? 117.925 147.481 117.701 1.00 43.02 ? 447 PHE A CA  1 
ATOM 3056 C C   . PHE A 1 404 ? 116.856 146.700 116.949 1.00 46.04 ? 447 PHE A C   1 
ATOM 3057 O O   . PHE A 1 404 ? 116.800 146.746 115.713 1.00 50.55 ? 447 PHE A O   1 
ATOM 3058 C CB  . PHE A 1 404 ? 119.073 146.554 118.096 1.00 42.23 ? 447 PHE A CB  1 
ATOM 3059 C CG  . PHE A 1 404 ? 119.334 145.464 117.097 1.00 41.15 ? 447 PHE A CG  1 
ATOM 3060 C CD1 . PHE A 1 404 ? 119.858 145.758 115.851 1.00 42.38 ? 447 PHE A CD1 1 
ATOM 3061 C CD2 . PHE A 1 404 ? 119.050 144.145 117.402 1.00 49.18 ? 447 PHE A CD2 1 
ATOM 3062 C CE1 . PHE A 1 404 ? 120.095 144.759 114.930 1.00 48.87 ? 447 PHE A CE1 1 
ATOM 3063 C CE2 . PHE A 1 404 ? 119.286 143.142 116.484 1.00 48.54 ? 447 PHE A CE2 1 
ATOM 3064 C CZ  . PHE A 1 404 ? 119.810 143.451 115.247 1.00 47.16 ? 447 PHE A CZ  1 
ATOM 3065 N N   . VAL A 1 405 ? 116.000 145.977 117.674 1.00 44.01 ? 448 VAL A N   1 
ATOM 3066 C CA  . VAL A 1 405 ? 114.965 145.182 117.017 1.00 39.78 ? 448 VAL A CA  1 
ATOM 3067 C C   . VAL A 1 405 ? 114.017 146.086 116.236 1.00 46.14 ? 448 VAL A C   1 
ATOM 3068 O O   . VAL A 1 405 ? 113.699 145.825 115.068 1.00 54.61 ? 448 VAL A O   1 
ATOM 3069 C CB  . VAL A 1 405 ? 114.211 144.324 118.049 1.00 46.91 ? 448 VAL A CB  1 
ATOM 3070 C CG1 . VAL A 1 405 ? 112.849 143.915 117.515 1.00 49.30 ? 448 VAL A CG1 1 
ATOM 3071 C CG2 . VAL A 1 405 ? 115.032 143.101 118.416 1.00 46.59 ? 448 VAL A CG2 1 
ATOM 3072 N N   . ASN A 1 406 ? 113.566 147.174 116.866 1.00 42.45 ? 449 ASN A N   1 
ATOM 3073 C CA  . ASN A 1 406 ? 112.648 148.093 116.201 1.00 39.86 ? 449 ASN A CA  1 
ATOM 3074 C C   . ASN A 1 406 ? 113.301 148.753 114.993 1.00 42.71 ? 449 ASN A C   1 
ATOM 3075 O O   . ASN A 1 406 ? 112.671 148.898 113.940 1.00 47.83 ? 449 ASN A O   1 
ATOM 3076 C CB  . ASN A 1 406 ? 112.160 149.151 117.189 1.00 43.15 ? 449 ASN A CB  1 
ATOM 3077 C CG  . ASN A 1 406 ? 111.142 148.608 118.167 1.00 44.76 ? 449 ASN A CG  1 
ATOM 3078 O OD1 . ASN A 1 406 ? 110.376 147.701 117.845 1.00 48.66 ? 449 ASN A OD1 1 
ATOM 3079 N ND2 . ASN A 1 406 ? 111.126 149.162 119.372 1.00 46.85 ? 449 ASN A ND2 1 
ATOM 3080 N N   . ARG A 1 407 ? 114.564 149.165 115.128 1.00 38.65 ? 450 ARG A N   1 
ATOM 3081 C CA  . ARG A 1 407 ? 115.261 149.801 114.016 1.00 39.95 ? 450 ARG A CA  1 
ATOM 3082 C C   . ARG A 1 407 ? 115.418 148.845 112.843 1.00 44.47 ? 450 ARG A C   1 
ATOM 3083 O O   . ARG A 1 407 ? 115.250 149.239 111.684 1.00 46.55 ? 450 ARG A O   1 
ATOM 3084 C CB  . ARG A 1 407 ? 116.625 150.307 114.484 1.00 41.20 ? 450 ARG A CB  1 
ATOM 3085 C CG  . ARG A 1 407 ? 117.319 151.240 113.513 1.00 44.11 ? 450 ARG A CG  1 
ATOM 3086 C CD  . ARG A 1 407 ? 118.488 151.941 114.182 1.00 42.79 ? 450 ARG A CD  1 
ATOM 3087 N NE  . ARG A 1 407 ? 119.531 151.001 114.572 1.00 42.47 ? 450 ARG A NE  1 
ATOM 3088 C CZ  . ARG A 1 407 ? 119.857 150.720 115.826 1.00 43.25 ? 450 ARG A CZ  1 
ATOM 3089 N NH1 . ARG A 1 407 ? 119.238 151.293 116.845 1.00 42.93 ? 450 ARG A NH1 1 
ATOM 3090 N NH2 . ARG A 1 407 ? 120.826 149.843 116.064 1.00 44.44 ? 450 ARG A NH2 1 
ATOM 3091 N N   . ALA A 1 408 ? 115.744 147.581 113.121 1.00 51.18 ? 451 ALA A N   1 
ATOM 3092 C CA  . ALA A 1 408 ? 115.910 146.617 112.041 1.00 40.57 ? 451 ALA A CA  1 
ATOM 3093 C C   . ALA A 1 408 ? 114.581 146.258 111.392 1.00 44.61 ? 451 ALA A C   1 
ATOM 3094 O O   . ALA A 1 408 ? 114.534 146.014 110.181 1.00 50.26 ? 451 ALA A O   1 
ATOM 3095 C CB  . ALA A 1 408 ? 116.603 145.358 112.560 1.00 47.53 ? 451 ALA A CB  1 
ATOM 3096 N N   . MET A 1 409 ? 113.496 146.221 112.166 1.00 47.08 ? 452 MET A N   1 
ATOM 3097 C CA  . MET A 1 409 ? 112.226 145.738 111.644 1.00 41.95 ? 452 MET A CA  1 
ATOM 3098 C C   . MET A 1 409 ? 111.357 146.824 111.021 1.00 46.09 ? 452 MET A C   1 
ATOM 3099 O O   . MET A 1 409 ? 110.495 146.502 110.196 1.00 49.91 ? 452 MET A O   1 
ATOM 3100 C CB  . MET A 1 409 ? 111.438 145.040 112.752 1.00 42.28 ? 452 MET A CB  1 
ATOM 3101 C CG  . MET A 1 409 ? 111.713 143.557 112.842 1.00 42.82 ? 452 MET A CG  1 
ATOM 3102 S SD  . MET A 1 409 ? 110.536 142.705 113.893 1.00 39.23 ? 452 MET A SD  1 
ATOM 3103 C CE  . MET A 1 409 ? 109.542 141.915 112.639 1.00 42.43 ? 452 MET A CE  1 
ATOM 3104 N N   . ASN A 1 410 ? 111.551 148.093 111.385 1.00 46.23 ? 453 ASN A N   1 
ATOM 3105 C CA  . ASN A 1 410 ? 110.690 149.158 110.893 1.00 41.82 ? 453 ASN A CA  1 
ATOM 3106 C C   . ASN A 1 410 ? 111.392 150.170 110.000 1.00 38.73 ? 453 ASN A C   1 
ATOM 3107 O O   . ASN A 1 410 ? 110.715 150.859 109.233 1.00 40.36 ? 453 ASN A O   1 
ATOM 3108 C CB  . ASN A 1 410 ? 110.042 149.905 112.067 1.00 42.10 ? 453 ASN A CB  1 
ATOM 3109 C CG  . ASN A 1 410 ? 109.037 149.053 112.814 1.00 47.01 ? 453 ASN A CG  1 
ATOM 3110 O OD1 . ASN A 1 410 ? 108.478 148.107 112.262 1.00 46.43 ? 453 ASN A OD1 1 
ATOM 3111 N ND2 . ASN A 1 410 ? 108.801 149.386 114.077 1.00 51.17 ? 453 ASN A ND2 1 
ATOM 3112 N N   . ASP A 1 411 ? 112.717 150.280 110.074 1.00 40.81 ? 454 ASP A N   1 
ATOM 3113 C CA  . ASP A 1 411 ? 113.457 151.239 109.263 1.00 40.27 ? 454 ASP A CA  1 
ATOM 3114 C C   . ASP A 1 411 ? 114.128 150.593 108.057 1.00 48.27 ? 454 ASP A C   1 
ATOM 3115 O O   . ASP A 1 411 ? 113.957 151.063 106.929 1.00 51.80 ? 454 ASP A O   1 
ATOM 3116 C CB  . ASP A 1 411 ? 114.507 151.956 110.119 1.00 46.25 ? 454 ASP A CB  1 
ATOM 3117 C CG  . ASP A 1 411 ? 113.900 153.010 111.022 1.00 54.59 ? 454 ASP A CG  1 
ATOM 3118 O OD1 . ASP A 1 411 ? 112.686 153.273 110.898 1.00 54.29 ? 454 ASP A OD1 1 
ATOM 3119 O OD2 . ASP A 1 411 ? 114.638 153.576 111.854 1.00 51.54 ? 454 ASP A OD2 1 
ATOM 3120 N N   . TRP A 1 412 ? 114.892 149.523 108.273 1.00 44.93 ? 455 TRP A N   1 
ATOM 3121 C CA  . TRP A 1 412 ? 115.596 148.861 107.182 1.00 45.95 ? 455 TRP A CA  1 
ATOM 3122 C C   . TRP A 1 412 ? 114.721 147.842 106.461 1.00 49.14 ? 455 TRP A C   1 
ATOM 3123 O O   . TRP A 1 412 ? 114.793 147.724 105.234 1.00 54.40 ? 455 TRP A O   1 
ATOM 3124 C CB  . TRP A 1 412 ? 116.861 148.180 107.710 1.00 48.04 ? 455 TRP A CB  1 
ATOM 3125 C CG  . TRP A 1 412 ? 117.790 149.114 108.426 1.00 49.20 ? 455 TRP A CG  1 
ATOM 3126 C CD1 . TRP A 1 412 ? 118.048 150.414 108.110 1.00 45.17 ? 455 TRP A CD1 1 
ATOM 3127 C CD2 . TRP A 1 412 ? 118.585 148.817 109.579 1.00 52.23 ? 455 TRP A CD2 1 
ATOM 3128 N NE1 . TRP A 1 412 ? 118.952 150.946 108.996 1.00 40.52 ? 455 TRP A NE1 1 
ATOM 3129 C CE2 . TRP A 1 412 ? 119.298 149.984 109.907 1.00 44.73 ? 455 TRP A CE2 1 
ATOM 3130 C CE3 . TRP A 1 412 ? 118.763 147.675 110.365 1.00 51.98 ? 455 TRP A CE3 1 
ATOM 3131 C CZ2 . TRP A 1 412 ? 120.170 150.045 110.990 1.00 51.55 ? 455 TRP A CZ2 1 
ATOM 3132 C CZ3 . TRP A 1 412 ? 119.631 147.737 111.437 1.00 49.22 ? 455 TRP A CZ3 1 
ATOM 3133 C CH2 . TRP A 1 412 ? 120.325 148.912 111.739 1.00 49.22 ? 455 TRP A CH2 1 
ATOM 3134 N N   . GLY A 1 413 ? 113.901 147.100 107.199 1.00 45.10 ? 456 GLY A N   1 
ATOM 3135 C CA  . GLY A 1 413 ? 113.028 146.109 106.604 1.00 39.10 ? 456 GLY A CA  1 
ATOM 3136 C C   . GLY A 1 413 ? 113.582 144.706 106.732 1.00 45.19 ? 456 GLY A C   1 
ATOM 3137 O O   . GLY A 1 413 ? 114.451 144.305 105.954 1.00 57.37 ? 456 GLY A O   1 
ATOM 3138 N N   . PHE A 1 414 ? 113.085 143.949 107.705 1.00 34.45 ? 457 PHE A N   1 
ATOM 3139 C CA  . PHE A 1 414 ? 113.579 142.603 107.950 1.00 32.34 ? 457 PHE A CA  1 
ATOM 3140 C C   . PHE A 1 414 ? 112.487 141.812 108.651 1.00 37.31 ? 457 PHE A C   1 
ATOM 3141 O O   . PHE A 1 414 ? 111.716 142.362 109.441 1.00 46.46 ? 457 PHE A O   1 
ATOM 3142 C CB  . PHE A 1 414 ? 114.864 142.620 108.787 1.00 38.07 ? 457 PHE A CB  1 
ATOM 3143 C CG  . PHE A 1 414 ? 116.118 142.798 107.973 1.00 38.95 ? 457 PHE A CG  1 
ATOM 3144 C CD1 . PHE A 1 414 ? 116.624 141.757 107.216 1.00 39.44 ? 457 PHE A CD1 1 
ATOM 3145 C CD2 . PHE A 1 414 ? 116.792 144.007 107.971 1.00 46.09 ? 457 PHE A CD2 1 
ATOM 3146 C CE1 . PHE A 1 414 ? 117.774 141.919 106.471 1.00 35.86 ? 457 PHE A CE1 1 
ATOM 3147 C CE2 . PHE A 1 414 ? 117.944 144.172 107.224 1.00 39.40 ? 457 PHE A CE2 1 
ATOM 3148 C CZ  . PHE A 1 414 ? 118.433 143.128 106.476 1.00 34.08 ? 457 PHE A CZ  1 
ATOM 3149 N N   . ASP A 1 415 ? 112.426 140.516 108.350 1.00 34.65 ? 458 ASP A N   1 
ATOM 3150 C CA  . ASP A 1 415 ? 111.348 139.658 108.823 1.00 40.77 ? 458 ASP A CA  1 
ATOM 3151 C C   . ASP A 1 415 ? 111.797 138.645 109.868 1.00 45.82 ? 458 ASP A C   1 
ATOM 3152 O O   . ASP A 1 415 ? 111.009 137.771 110.243 1.00 53.00 ? 458 ASP A O   1 
ATOM 3153 C CB  . ASP A 1 415 ? 110.699 138.937 107.641 1.00 45.50 ? 458 ASP A CB  1 
ATOM 3154 C CG  . ASP A 1 415 ? 110.498 139.845 106.445 1.00 53.12 ? 458 ASP A CG  1 
ATOM 3155 O OD1 . ASP A 1 415 ? 111.504 140.231 105.815 1.00 55.11 ? 458 ASP A OD1 1 
ATOM 3156 O OD2 . ASP A 1 415 ? 109.334 140.173 106.136 1.00 55.35 ? 458 ASP A OD2 1 
ATOM 3157 N N   . GLY A 1 416 ? 113.030 138.735 110.348 1.00 45.07 ? 459 GLY A N   1 
ATOM 3158 C CA  . GLY A 1 416 ? 113.491 137.792 111.350 1.00 45.40 ? 459 GLY A CA  1 
ATOM 3159 C C   . GLY A 1 416 ? 114.937 138.050 111.706 1.00 49.20 ? 459 GLY A C   1 
ATOM 3160 O O   . GLY A 1 416 ? 115.609 138.899 111.113 1.00 48.67 ? 459 GLY A O   1 
ATOM 3161 N N   . PHE A 1 417 ? 115.411 137.291 112.693 1.00 54.92 ? 460 PHE A N   1 
ATOM 3162 C CA  . PHE A 1 417 ? 116.764 137.441 113.205 1.00 55.01 ? 460 PHE A CA  1 
ATOM 3163 C C   . PHE A 1 417 ? 117.367 136.068 113.467 1.00 55.99 ? 460 PHE A C   1 
ATOM 3164 O O   . PHE A 1 417 ? 116.655 135.084 113.680 1.00 52.79 ? 460 PHE A O   1 
ATOM 3165 C CB  . PHE A 1 417 ? 116.790 138.283 114.487 1.00 57.65 ? 460 PHE A CB  1 
ATOM 3166 C CG  . PHE A 1 417 ? 116.220 139.660 114.316 1.00 55.03 ? 460 PHE A CG  1 
ATOM 3167 C CD1 . PHE A 1 417 ? 117.021 140.707 113.899 1.00 55.15 ? 460 PHE A CD1 1 
ATOM 3168 C CD2 . PHE A 1 417 ? 114.883 139.907 114.570 1.00 53.70 ? 460 PHE A CD2 1 
ATOM 3169 C CE1 . PHE A 1 417 ? 116.500 141.973 113.739 1.00 57.16 ? 460 PHE A CE1 1 
ATOM 3170 C CE2 . PHE A 1 417 ? 114.356 141.171 114.410 1.00 57.81 ? 460 PHE A CE2 1 
ATOM 3171 C CZ  . PHE A 1 417 ? 115.166 142.205 113.994 1.00 56.13 ? 460 PHE A CZ  1 
ATOM 3172 N N   . LYS A 1 418 ? 118.698 136.015 113.448 1.00 64.01 ? 461 LYS A N   1 
ATOM 3173 C CA  . LYS A 1 418 ? 119.452 134.788 113.685 1.00 59.17 ? 461 LYS A CA  1 
ATOM 3174 C C   . LYS A 1 418 ? 120.414 135.020 114.843 1.00 63.81 ? 461 LYS A C   1 
ATOM 3175 O O   . LYS A 1 418 ? 121.362 135.804 114.720 1.00 62.92 ? 461 LYS A O   1 
ATOM 3176 C CB  . LYS A 1 418 ? 120.205 134.357 112.428 1.00 56.94 ? 461 LYS A CB  1 
ATOM 3177 C CG  . LYS A 1 418 ? 120.238 132.856 112.206 1.00 62.98 ? 461 LYS A CG  1 
ATOM 3178 C CD  . LYS A 1 418 ? 121.339 132.465 111.236 1.00 63.07 ? 461 LYS A CD  1 
ATOM 3179 C CE  . LYS A 1 418 ? 122.630 132.143 111.969 1.00 63.22 ? 461 LYS A CE  1 
ATOM 3180 N NZ  . LYS A 1 418 ? 123.361 131.011 111.335 1.00 62.50 ? 461 LYS A NZ  1 
ATOM 3181 N N   . GLY A 1 419 ? 120.176 134.338 115.962 1.00 59.20 ? 462 GLY A N   1 
ATOM 3182 C CA  . GLY A 1 419 ? 121.063 134.424 117.110 1.00 56.25 ? 462 GLY A CA  1 
ATOM 3183 C C   . GLY A 1 419 ? 122.224 133.452 116.978 1.00 56.41 ? 462 GLY A C   1 
ATOM 3184 O O   . GLY A 1 419 ? 122.045 132.297 116.597 1.00 61.67 ? 462 GLY A O   1 
ATOM 3185 N N   . ASP A 1 420 ? 123.421 133.937 117.298 1.00 56.82 ? 463 ASP A N   1 
ATOM 3186 C CA  . ASP A 1 420 ? 124.626 133.155 117.061 1.00 53.64 ? 463 ASP A CA  1 
ATOM 3187 C C   . ASP A 1 420 ? 125.735 133.621 117.991 1.00 52.72 ? 463 ASP A C   1 
ATOM 3188 O O   . ASP A 1 420 ? 125.770 134.779 118.418 1.00 58.72 ? 463 ASP A O   1 
ATOM 3189 C CB  . ASP A 1 420 ? 125.074 133.268 115.599 1.00 54.41 ? 463 ASP A CB  1 
ATOM 3190 C CG  . ASP A 1 420 ? 126.034 132.169 115.193 1.00 60.32 ? 463 ASP A CG  1 
ATOM 3191 O OD1 . ASP A 1 420 ? 127.175 132.155 115.700 1.00 62.02 ? 463 ASP A OD1 1 
ATOM 3192 O OD2 . ASP A 1 420 ? 125.649 131.321 114.362 1.00 60.64 ? 463 ASP A OD2 1 
ATOM 3193 N N   . TYR A 1 421 ? 126.639 132.690 118.301 1.00 44.05 ? 464 TYR A N   1 
ATOM 3194 C CA  . TYR A 1 421 ? 127.920 132.986 118.941 1.00 39.19 ? 464 TYR A CA  1 
ATOM 3195 C C   . TYR A 1 421 ? 127.735 133.593 120.335 1.00 47.93 ? 464 TYR A C   1 
ATOM 3196 O O   . TYR A 1 421 ? 128.225 134.682 120.639 1.00 55.10 ? 464 TYR A O   1 
ATOM 3197 C CB  . TYR A 1 421 ? 128.759 133.902 118.044 1.00 42.41 ? 464 TYR A CB  1 
ATOM 3198 C CG  . TYR A 1 421 ? 130.202 133.485 117.896 1.00 48.01 ? 464 TYR A CG  1 
ATOM 3199 C CD1 . TYR A 1 421 ? 130.835 133.545 116.663 1.00 49.75 ? 464 TYR A CD1 1 
ATOM 3200 C CD2 . TYR A 1 421 ? 130.933 133.038 118.984 1.00 51.40 ? 464 TYR A CD2 1 
ATOM 3201 C CE1 . TYR A 1 421 ? 132.154 133.168 116.518 1.00 52.95 ? 464 TYR A CE1 1 
ATOM 3202 C CE2 . TYR A 1 421 ? 132.254 132.658 118.849 1.00 50.21 ? 464 TYR A CE2 1 
ATOM 3203 C CZ  . TYR A 1 421 ? 132.859 132.725 117.615 1.00 52.92 ? 464 TYR A CZ  1 
ATOM 3204 O OH  . TYR A 1 421 ? 134.174 132.348 117.475 1.00 55.69 ? 464 TYR A OH  1 
ATOM 3205 N N   . VAL A 1 422 ? 127.018 132.862 121.185 1.00 48.82 ? 465 VAL A N   1 
ATOM 3206 C CA  . VAL A 1 422 ? 126.867 133.236 122.589 1.00 51.58 ? 465 VAL A CA  1 
ATOM 3207 C C   . VAL A 1 422 ? 126.540 131.975 123.377 1.00 51.65 ? 465 VAL A C   1 
ATOM 3208 O O   . VAL A 1 422 ? 125.824 131.093 122.893 1.00 58.29 ? 465 VAL A O   1 
ATOM 3209 C CB  . VAL A 1 422 ? 125.795 134.339 122.770 1.00 51.85 ? 465 VAL A CB  1 
ATOM 3210 C CG1 . VAL A 1 422 ? 124.387 133.767 122.686 1.00 53.66 ? 465 VAL A CG1 1 
ATOM 3211 C CG2 . VAL A 1 422 ? 126.002 135.069 124.087 1.00 55.84 ? 465 VAL A CG2 1 
ATOM 3212 N N   . TRP A 1 423 ? 127.103 131.871 124.578 1.00 44.40 ? 466 TRP A N   1 
ATOM 3213 C CA  . TRP A 1 423 ? 126.882 130.637 125.325 1.00 44.91 ? 466 TRP A CA  1 
ATOM 3214 C C   . TRP A 1 423 ? 126.357 130.835 126.740 1.00 47.32 ? 466 TRP A C   1 
ATOM 3215 O O   . TRP A 1 423 ? 125.459 130.100 127.155 1.00 54.81 ? 466 TRP A O   1 
ATOM 3216 C CB  . TRP A 1 423 ? 128.182 129.828 125.373 1.00 45.34 ? 466 TRP A CB  1 
ATOM 3217 C CG  . TRP A 1 423 ? 128.537 129.213 124.063 1.00 48.35 ? 466 TRP A CG  1 
ATOM 3218 C CD1 . TRP A 1 423 ? 128.084 128.029 123.565 1.00 47.57 ? 466 TRP A CD1 1 
ATOM 3219 C CD2 . TRP A 1 423 ? 129.422 129.751 123.076 1.00 44.57 ? 466 TRP A CD2 1 
ATOM 3220 N NE1 . TRP A 1 423 ? 128.632 127.794 122.330 1.00 48.83 ? 466 TRP A NE1 1 
ATOM 3221 C CE2 . TRP A 1 423 ? 129.458 128.837 122.007 1.00 41.48 ? 466 TRP A CE2 1 
ATOM 3222 C CE3 . TRP A 1 423 ? 130.189 130.915 122.994 1.00 46.38 ? 466 TRP A CE3 1 
ATOM 3223 C CZ2 . TRP A 1 423 ? 130.228 129.052 120.871 1.00 50.23 ? 466 TRP A CZ2 1 
ATOM 3224 C CZ3 . TRP A 1 423 ? 130.952 131.125 121.866 1.00 47.91 ? 466 TRP A CZ3 1 
ATOM 3225 C CH2 . TRP A 1 423 ? 130.967 130.199 120.820 1.00 47.63 ? 466 TRP A CH2 1 
ATOM 3226 N N   . SER A 1 424 ? 126.877 131.805 127.489 1.00 39.55 ? 467 SER A N   1 
ATOM 3227 C CA  . SER A 1 424 ? 126.534 131.887 128.903 1.00 39.66 ? 467 SER A CA  1 
ATOM 3228 C C   . SER A 1 424 ? 126.830 133.282 129.431 1.00 43.01 ? 467 SER A C   1 
ATOM 3229 O O   . SER A 1 424 ? 127.528 134.073 128.795 1.00 49.94 ? 467 SER A O   1 
ATOM 3230 C CB  . SER A 1 424 ? 127.290 130.836 129.721 1.00 48.93 ? 467 SER A CB  1 
ATOM 3231 O OG  . SER A 1 424 ? 126.721 130.690 131.010 1.00 55.81 ? 467 SER A OG  1 
ATOM 3232 N N   . MET A 1 425 ? 126.291 133.565 130.618 1.00 45.50 ? 468 MET A N   1 
ATOM 3233 C CA  . MET A 1 425 ? 126.387 134.876 131.246 1.00 47.94 ? 468 MET A CA  1 
ATOM 3234 C C   . MET A 1 425 ? 127.242 134.797 132.501 1.00 55.93 ? 468 MET A C   1 
ATOM 3235 O O   . MET A 1 425 ? 126.953 133.978 133.386 1.00 61.87 ? 468 MET A O   1 
ATOM 3236 C CB  . MET A 1 425 ? 124.994 135.405 131.586 1.00 46.46 ? 468 MET A CB  1 
ATOM 3237 C CG  . MET A 1 425 ? 124.979 136.821 132.130 1.00 50.29 ? 468 MET A CG  1 
ATOM 3238 S SD  . MET A 1 425 ? 124.986 138.075 130.836 1.00 67.98 ? 468 MET A SD  1 
ATOM 3239 C CE  . MET A 1 425 ? 123.703 137.458 129.752 1.00 53.58 ? 468 MET A CE  1 
ATOM 3240 N N   . PRO A 1 426 ? 128.289 135.609 132.627 1.00 45.55 ? 469 PRO A N   1 
ATOM 3241 C CA  . PRO A 1 426 ? 129.121 135.568 133.834 1.00 38.19 ? 469 PRO A CA  1 
ATOM 3242 C C   . PRO A 1 426 ? 128.432 136.232 135.017 1.00 44.96 ? 469 PRO A C   1 
ATOM 3243 O O   . PRO A 1 426 ? 127.438 136.949 134.885 1.00 51.94 ? 469 PRO A O   1 
ATOM 3244 C CB  . PRO A 1 426 ? 130.380 136.330 133.420 1.00 39.30 ? 469 PRO A CB  1 
ATOM 3245 C CG  . PRO A 1 426 ? 129.920 137.251 132.353 1.00 44.46 ? 469 PRO A CG  1 
ATOM 3246 C CD  . PRO A 1 426 ? 128.813 136.548 131.622 1.00 41.74 ? 469 PRO A CD  1 
ATOM 3247 N N   . GLU A 1 427 ? 128.987 135.977 136.199 1.00 45.19 ? 470 GLU A N   1 
ATOM 3248 C CA  . GLU A 1 427 ? 128.450 136.542 137.429 1.00 46.40 ? 470 GLU A CA  1 
ATOM 3249 C C   . GLU A 1 427 ? 128.794 138.023 137.543 1.00 57.17 ? 470 GLU A C   1 
ATOM 3250 O O   . GLU A 1 427 ? 129.815 138.489 137.029 1.00 61.90 ? 470 GLU A O   1 
ATOM 3251 C CB  . GLU A 1 427 ? 128.992 135.786 138.640 1.00 50.21 ? 470 GLU A CB  1 
ATOM 3252 C CG  . GLU A 1 427 ? 129.197 134.301 138.402 1.00 56.82 ? 470 GLU A CG  1 
ATOM 3253 C CD  . GLU A 1 427 ? 129.199 133.500 139.688 1.00 62.09 ? 470 GLU A CD  1 
ATOM 3254 O OE1 . GLU A 1 427 ? 129.233 134.117 140.774 1.00 63.42 ? 470 GLU A OE1 1 
ATOM 3255 O OE2 . GLU A 1 427 ? 129.168 132.254 139.614 1.00 63.52 ? 470 GLU A OE2 1 
ATOM 3256 N N   . CYS A 1 428 ? 127.931 138.765 138.236 1.00 57.91 ? 471 CYS A N   1 
ATOM 3257 C CA  . CYS A 1 428 ? 128.061 140.209 138.380 1.00 54.02 ? 471 CYS A CA  1 
ATOM 3258 C C   . CYS A 1 428 ? 128.226 140.570 139.850 1.00 56.11 ? 471 CYS A C   1 
ATOM 3259 O O   . CYS A 1 428 ? 127.500 140.053 140.705 1.00 55.07 ? 471 CYS A O   1 
ATOM 3260 C CB  . CYS A 1 428 ? 126.844 140.931 137.793 1.00 58.16 ? 471 CYS A CB  1 
ATOM 3261 S SG  . CYS A 1 428 ? 127.002 142.730 137.721 1.00 63.95 ? 471 CYS A SG  1 
ATOM 3262 N N   . TYR A 1 429 ? 129.177 141.462 140.136 1.00 64.21 ? 472 TYR A N   1 
ATOM 3263 C CA  . TYR A 1 429 ? 129.472 141.891 141.500 1.00 59.24 ? 472 TYR A CA  1 
ATOM 3264 C C   . TYR A 1 429 ? 129.277 143.392 141.691 1.00 62.75 ? 472 TYR A C   1 
ATOM 3265 O O   . TYR A 1 429 ? 129.833 143.968 142.631 1.00 64.81 ? 472 TYR A O   1 
ATOM 3266 C CB  . TYR A 1 429 ? 130.900 141.498 141.886 1.00 58.43 ? 472 TYR A CB  1 
ATOM 3267 C CG  . TYR A 1 429 ? 131.117 140.010 142.036 1.00 61.06 ? 472 TYR A CG  1 
ATOM 3268 C CD1 . TYR A 1 429 ? 130.807 139.361 143.221 1.00 60.38 ? 472 TYR A CD1 1 
ATOM 3269 C CD2 . TYR A 1 429 ? 131.633 139.255 140.992 1.00 62.43 ? 472 TYR A CD2 1 
ATOM 3270 C CE1 . TYR A 1 429 ? 131.005 138.003 143.364 1.00 60.62 ? 472 TYR A CE1 1 
ATOM 3271 C CE2 . TYR A 1 429 ? 131.835 137.897 141.125 1.00 63.02 ? 472 TYR A CE2 1 
ATOM 3272 C CZ  . TYR A 1 429 ? 131.518 137.276 142.313 1.00 63.44 ? 472 TYR A CZ  1 
ATOM 3273 O OH  . TYR A 1 429 ? 131.717 135.921 142.452 1.00 63.85 ? 472 TYR A OH  1 
ATOM 3274 N N   . ASN A 1 430 ? 128.505 144.037 140.825 1.00 59.94 ? 473 ASN A N   1 
ATOM 3275 C CA  . ASN A 1 430 ? 128.297 145.477 140.929 1.00 50.89 ? 473 ASN A CA  1 
ATOM 3276 C C   . ASN A 1 430 ? 127.335 145.782 142.071 1.00 52.38 ? 473 ASN A C   1 
ATOM 3277 O O   . ASN A 1 430 ? 126.196 145.302 142.051 1.00 55.16 ? 473 ASN A O   1 
ATOM 3278 C CB  . ASN A 1 430 ? 127.750 146.031 139.620 1.00 45.35 ? 473 ASN A CB  1 
ATOM 3279 C CG  . ASN A 1 430 ? 128.122 147.483 139.400 1.00 52.65 ? 473 ASN A CG  1 
ATOM 3280 O OD1 . ASN A 1 430 ? 128.370 148.223 140.350 1.00 58.38 ? 473 ASN A OD1 1 
ATOM 3281 N ND2 . ASN A 1 430 ? 128.159 147.898 138.141 1.00 53.68 ? 473 ASN A ND2 1 
ATOM 3282 N N   . PRO A 1 431 ? 127.743 146.561 143.078 1.00 46.01 ? 474 PRO A N   1 
ATOM 3283 C CA  . PRO A 1 431 ? 126.814 146.893 144.169 1.00 48.46 ? 474 PRO A CA  1 
ATOM 3284 C C   . PRO A 1 431 ? 125.676 147.804 143.748 1.00 52.76 ? 474 PRO A C   1 
ATOM 3285 O O   . PRO A 1 431 ? 124.637 147.816 144.419 1.00 51.74 ? 474 PRO A O   1 
ATOM 3286 C CB  . PRO A 1 431 ? 127.717 147.573 145.205 1.00 49.75 ? 474 PRO A CB  1 
ATOM 3287 C CG  . PRO A 1 431 ? 128.855 148.113 144.409 1.00 49.24 ? 474 PRO A CG  1 
ATOM 3288 C CD  . PRO A 1 431 ? 129.080 147.139 143.291 1.00 47.86 ? 474 PRO A CD  1 
ATOM 3289 N N   . ALA A 1 432 ? 125.837 148.570 142.666 1.00 56.49 ? 475 ALA A N   1 
ATOM 3290 C CA  . ALA A 1 432 ? 124.775 149.469 142.227 1.00 49.32 ? 475 ALA A CA  1 
ATOM 3291 C C   . ALA A 1 432 ? 123.543 148.695 141.774 1.00 50.27 ? 475 ALA A C   1 
ATOM 3292 O O   . ALA A 1 432 ? 122.410 149.117 142.031 1.00 55.78 ? 475 ALA A O   1 
ATOM 3293 C CB  . ALA A 1 432 ? 125.283 150.373 141.105 1.00 48.34 ? 475 ALA A CB  1 
ATOM 3294 N N   . HIS A 1 433 ? 123.744 147.563 141.096 1.00 46.45 ? 476 HIS A N   1 
ATOM 3295 C CA  . HIS A 1 433 ? 122.623 146.781 140.589 1.00 42.68 ? 476 HIS A CA  1 
ATOM 3296 C C   . HIS A 1 433 ? 121.795 146.155 141.703 1.00 42.74 ? 476 HIS A C   1 
ATOM 3297 O O   . HIS A 1 433 ? 120.671 145.714 141.442 1.00 53.09 ? 476 HIS A O   1 
ATOM 3298 C CB  . HIS A 1 433 ? 123.126 145.686 139.650 1.00 48.11 ? 476 HIS A CB  1 
ATOM 3299 C CG  . HIS A 1 433 ? 123.840 146.203 138.440 1.00 49.69 ? 476 HIS A CG  1 
ATOM 3300 N ND1 . HIS A 1 433 ? 124.387 145.369 137.489 1.00 51.73 ? 476 HIS A ND1 1 
ATOM 3301 C CD2 . HIS A 1 433 ? 124.097 147.465 138.026 1.00 48.18 ? 476 HIS A CD2 1 
ATOM 3302 C CE1 . HIS A 1 433 ? 124.950 146.097 136.541 1.00 52.66 ? 476 HIS A CE1 1 
ATOM 3303 N NE2 . HIS A 1 433 ? 124.788 147.372 136.843 1.00 49.50 ? 476 HIS A NE2 1 
ATOM 3304 N N   . ASN A 1 434 ? 122.325 146.102 142.926 1.00 41.39 ? 477 ASN A N   1 
ATOM 3305 C CA  . ASN A 1 434 ? 121.627 145.523 144.076 1.00 42.61 ? 477 ASN A CA  1 
ATOM 3306 C C   . ASN A 1 434 ? 121.264 144.060 143.826 1.00 49.40 ? 477 ASN A C   1 
ATOM 3307 O O   . ASN A 1 434 ? 120.127 143.631 144.034 1.00 54.60 ? 477 ASN A O   1 
ATOM 3308 C CB  . ASN A 1 434 ? 120.386 146.343 144.439 1.00 50.79 ? 477 ASN A CB  1 
ATOM 3309 C CG  . ASN A 1 434 ? 120.704 147.510 145.349 1.00 57.79 ? 477 ASN A CG  1 
ATOM 3310 O OD1 . ASN A 1 434 ? 121.868 147.855 145.551 1.00 60.17 ? 477 ASN A OD1 1 
ATOM 3311 N ND2 . ASN A 1 434 ? 119.668 148.127 145.905 1.00 53.96 ? 477 ASN A ND2 1 
ATOM 3312 N N   . HIS A 1 435 ? 122.248 143.289 143.370 1.00 46.66 ? 478 HIS A N   1 
ATOM 3313 C CA  . HIS A 1 435 ? 122.038 141.868 143.136 1.00 38.53 ? 478 HIS A CA  1 
ATOM 3314 C C   . HIS A 1 435 ? 121.885 141.135 144.463 1.00 42.05 ? 478 HIS A C   1 
ATOM 3315 O O   . HIS A 1 435 ? 122.673 141.340 145.391 1.00 45.41 ? 478 HIS A O   1 
ATOM 3316 C CB  . HIS A 1 435 ? 123.206 141.281 142.343 1.00 43.17 ? 478 HIS A CB  1 
ATOM 3317 C CG  . HIS A 1 435 ? 123.250 141.715 140.911 1.00 38.71 ? 478 HIS A CG  1 
ATOM 3318 N ND1 . HIS A 1 435 ? 122.236 141.444 140.020 1.00 40.60 ? 478 HIS A ND1 1 
ATOM 3319 C CD2 . HIS A 1 435 ? 124.193 142.390 140.213 1.00 45.60 ? 478 HIS A CD2 1 
ATOM 3320 C CE1 . HIS A 1 435 ? 122.548 141.940 138.836 1.00 38.02 ? 478 HIS A CE1 1 
ATOM 3321 N NE2 . HIS A 1 435 ? 123.732 142.518 138.925 1.00 30.13 ? 478 HIS A NE2 1 
ATOM 3322 N N   . ALA A 1 436 ? 120.863 140.281 144.555 1.00 50.31 ? 479 ALA A N   1 
ATOM 3323 C CA  . ALA A 1 436 ? 120.692 139.467 145.754 1.00 50.10 ? 479 ALA A CA  1 
ATOM 3324 C C   . ALA A 1 436 ? 121.848 138.491 145.923 1.00 53.24 ? 479 ALA A C   1 
ATOM 3325 O O   . ALA A 1 436 ? 122.364 138.310 147.032 1.00 57.62 ? 479 ALA A O   1 
ATOM 3326 C CB  . ALA A 1 436 ? 119.361 138.719 145.698 1.00 49.47 ? 479 ALA A CB  1 
ATOM 3327 N N   . SER A 1 437 ? 122.267 137.853 144.836 1.00 52.80 ? 480 SER A N   1 
ATOM 3328 C CA  . SER A 1 437 ? 123.406 136.952 144.817 1.00 46.43 ? 480 SER A CA  1 
ATOM 3329 C C   . SER A 1 437 ? 124.196 137.201 143.543 1.00 55.84 ? 480 SER A C   1 
ATOM 3330 O O   . SER A 1 437 ? 123.636 137.674 142.547 1.00 63.58 ? 480 SER A O   1 
ATOM 3331 C CB  . SER A 1 437 ? 122.966 135.481 144.880 1.00 52.62 ? 480 SER A CB  1 
ATOM 3332 O OG  . SER A 1 437 ? 122.986 134.888 143.593 1.00 59.82 ? 480 SER A OG  1 
ATOM 3333 N N   . PRO A 1 438 ? 125.499 136.903 143.544 1.00 44.51 ? 481 PRO A N   1 
ATOM 3334 C CA  . PRO A 1 438 ? 126.295 137.090 142.320 1.00 42.35 ? 481 PRO A CA  1 
ATOM 3335 C C   . PRO A 1 438 ? 125.839 136.227 141.155 1.00 48.01 ? 481 PRO A C   1 
ATOM 3336 O O   . PRO A 1 438 ? 126.150 136.562 140.006 1.00 55.26 ? 481 PRO A O   1 
ATOM 3337 C CB  . PRO A 1 438 ? 127.716 136.721 142.762 1.00 41.96 ? 481 PRO A CB  1 
ATOM 3338 C CG  . PRO A 1 438 ? 127.716 136.922 144.236 1.00 49.85 ? 481 PRO A CG  1 
ATOM 3339 C CD  . PRO A 1 438 ? 126.340 136.551 144.699 1.00 50.25 ? 481 PRO A CD  1 
ATOM 3340 N N   . GLU A 1 439 ? 125.116 135.140 141.409 1.00 51.62 ? 482 GLU A N   1 
ATOM 3341 C CA  . GLU A 1 439 ? 124.629 134.271 140.348 1.00 48.90 ? 482 GLU A CA  1 
ATOM 3342 C C   . GLU A 1 439 ? 123.364 134.794 139.683 1.00 56.34 ? 482 GLU A C   1 
ATOM 3343 O O   . GLU A 1 439 ? 122.923 134.210 138.687 1.00 61.16 ? 482 GLU A O   1 
ATOM 3344 C CB  . GLU A 1 439 ? 124.367 132.863 140.894 1.00 49.41 ? 482 GLU A CB  1 
ATOM 3345 C CG  . GLU A 1 439 ? 125.575 132.198 141.535 1.00 55.73 ? 482 GLU A CG  1 
ATOM 3346 C CD  . GLU A 1 439 ? 125.758 132.588 142.989 1.00 59.13 ? 482 GLU A CD  1 
ATOM 3347 O OE1 . GLU A 1 439 ? 124.855 132.301 143.801 1.00 56.86 ? 482 GLU A OE1 1 
ATOM 3348 O OE2 . GLU A 1 439 ? 126.806 133.183 143.319 1.00 62.35 ? 482 GLU A OE2 1 
ATOM 3349 N N   . GLU A 1 440 ? 122.779 135.879 140.199 1.00 55.78 ? 483 GLU A N   1 
ATOM 3350 C CA  . GLU A 1 440 ? 121.530 136.392 139.646 1.00 53.65 ? 483 GLU A CA  1 
ATOM 3351 C C   . GLU A 1 440 ? 121.684 136.812 138.190 1.00 50.33 ? 483 GLU A C   1 
ATOM 3352 O O   . GLU A 1 440 ? 120.721 136.738 137.419 1.00 57.17 ? 483 GLU A O   1 
ATOM 3353 C CB  . GLU A 1 440 ? 121.030 137.566 140.487 1.00 55.05 ? 483 GLU A CB  1 
ATOM 3354 C CG  . GLU A 1 440 ? 119.650 137.358 141.085 1.00 60.53 ? 483 GLU A CG  1 
ATOM 3355 C CD  . GLU A 1 440 ? 118.990 138.661 141.489 1.00 63.50 ? 483 GLU A CD  1 
ATOM 3356 O OE1 . GLU A 1 440 ? 119.716 139.595 141.890 1.00 59.29 ? 483 GLU A OE1 1 
ATOM 3357 O OE2 . GLU A 1 440 ? 117.747 138.751 141.406 1.00 61.89 ? 483 GLU A OE2 1 
ATOM 3358 N N   . SER A 1 441 ? 122.876 137.258 137.796 1.00 37.97 ? 484 SER A N   1 
ATOM 3359 C CA  . SER A 1 441 ? 123.109 137.602 136.399 1.00 40.55 ? 484 SER A CA  1 
ATOM 3360 C C   . SER A 1 441 ? 123.106 136.364 135.512 1.00 45.26 ? 484 SER A C   1 
ATOM 3361 O O   . SER A 1 441 ? 122.648 136.419 134.366 1.00 50.77 ? 484 SER A O   1 
ATOM 3362 C CB  . SER A 1 441 ? 124.431 138.354 136.257 1.00 52.25 ? 484 SER A CB  1 
ATOM 3363 O OG  . SER A 1 441 ? 125.504 137.457 136.034 1.00 56.08 ? 484 SER A OG  1 
ATOM 3364 N N   . THR A 1 442 ? 123.607 135.240 136.028 1.00 51.89 ? 485 THR A N   1 
ATOM 3365 C CA  . THR A 1 442 ? 123.705 134.029 135.221 1.00 48.78 ? 485 THR A CA  1 
ATOM 3366 C C   . THR A 1 442 ? 122.338 133.412 134.953 1.00 48.58 ? 485 THR A C   1 
ATOM 3367 O O   . THR A 1 442 ? 122.152 132.739 133.932 1.00 56.62 ? 485 THR A O   1 
ATOM 3368 C CB  . THR A 1 442 ? 124.616 133.014 135.915 1.00 50.12 ? 485 THR A CB  1 
ATOM 3369 O OG1 . THR A 1 442 ? 125.804 133.671 136.373 1.00 58.48 ? 485 THR A OG1 1 
ATOM 3370 C CG2 . THR A 1 442 ? 125.004 131.895 134.961 1.00 48.55 ? 485 THR A CG2 1 
ATOM 3371 N N   . GLU A 1 443 ? 121.370 133.634 135.840 1.00 36.68 ? 486 GLU A N   1 
ATOM 3372 C CA  . GLU A 1 443 ? 120.082 132.960 135.766 1.00 33.86 ? 486 GLU A CA  1 
ATOM 3373 C C   . GLU A 1 443 ? 119.013 133.783 135.054 1.00 42.10 ? 486 GLU A C   1 
ATOM 3374 O O   . GLU A 1 443 ? 117.823 133.482 135.195 1.00 49.98 ? 486 GLU A O   1 
ATOM 3375 C CB  . GLU A 1 443 ? 119.594 132.593 137.168 1.00 43.45 ? 486 GLU A CB  1 
ATOM 3376 C CG  . GLU A 1 443 ? 120.520 131.681 137.953 1.00 48.63 ? 486 GLU A CG  1 
ATOM 3377 C CD  . GLU A 1 443 ? 120.382 131.869 139.453 1.00 53.98 ? 486 GLU A CD  1 
ATOM 3378 O OE1 . GLU A 1 443 ? 121.233 132.553 140.056 1.00 52.63 ? 486 GLU A OE1 1 
ATOM 3379 O OE2 . GLU A 1 443 ? 119.416 131.330 140.031 1.00 57.69 ? 486 GLU A OE2 1 
ATOM 3380 N N   . LYS A 1 444 ? 119.395 134.812 134.296 1.00 45.03 ? 487 LYS A N   1 
ATOM 3381 C CA  . LYS A 1 444 ? 118.396 135.710 133.720 1.00 40.22 ? 487 LYS A CA  1 
ATOM 3382 C C   . LYS A 1 444 ? 118.722 136.073 132.273 1.00 45.10 ? 487 LYS A C   1 
ATOM 3383 O O   . LYS A 1 444 ? 118.526 137.214 131.846 1.00 51.21 ? 487 LYS A O   1 
ATOM 3384 C CB  . LYS A 1 444 ? 118.245 136.970 134.570 1.00 39.89 ? 487 LYS A CB  1 
ATOM 3385 C CG  . LYS A 1 444 ? 117.451 136.751 135.847 1.00 41.78 ? 487 LYS A CG  1 
ATOM 3386 C CD  . LYS A 1 444 ? 117.303 138.034 136.640 1.00 47.73 ? 487 LYS A CD  1 
ATOM 3387 C CE  . LYS A 1 444 ? 116.042 138.010 137.487 1.00 50.35 ? 487 LYS A CE  1 
ATOM 3388 N NZ  . LYS A 1 444 ? 115.171 136.852 137.152 1.00 48.86 ? 487 LYS A NZ  1 
ATOM 3389 N N   . GLN A 1 445 ? 119.201 135.108 131.485 1.00 37.23 ? 488 GLN A N   1 
ATOM 3390 C CA  . GLN A 1 445 ? 119.297 135.320 130.042 1.00 32.45 ? 488 GLN A CA  1 
ATOM 3391 C C   . GLN A 1 445 ? 117.937 135.189 129.365 1.00 43.10 ? 488 GLN A C   1 
ATOM 3392 O O   . GLN A 1 445 ? 117.676 135.840 128.335 1.00 53.30 ? 488 GLN A O   1 
ATOM 3393 C CB  . GLN A 1 445 ? 120.286 134.329 129.431 1.00 42.21 ? 488 GLN A CB  1 
ATOM 3394 C CG  . GLN A 1 445 ? 121.679 134.400 130.023 1.00 42.31 ? 488 GLN A CG  1 
ATOM 3395 C CD  . GLN A 1 445 ? 122.683 133.583 129.239 1.00 46.00 ? 488 GLN A CD  1 
ATOM 3396 O OE1 . GLN A 1 445 ? 123.233 134.047 128.241 1.00 47.82 ? 488 GLN A OE1 1 
ATOM 3397 N NE2 . GLN A 1 445 ? 122.931 132.360 129.688 1.00 45.03 ? 488 GLN A NE2 1 
ATOM 3398 N N   . SER A 1 446 ? 117.067 134.351 129.934 1.00 33.46 ? 489 SER A N   1 
ATOM 3399 C CA  . SER A 1 446 ? 115.723 134.189 129.401 1.00 42.34 ? 489 SER A CA  1 
ATOM 3400 C C   . SER A 1 446 ? 114.970 135.509 129.373 1.00 45.11 ? 489 SER A C   1 
ATOM 3401 O O   . SER A 1 446 ? 114.111 135.707 128.511 1.00 48.28 ? 489 SER A O   1 
ATOM 3402 C CB  . SER A 1 446 ? 114.955 133.156 130.226 1.00 45.70 ? 489 SER A CB  1 
ATOM 3403 O OG  . SER A 1 446 ? 114.441 133.733 131.413 1.00 46.85 ? 489 SER A OG  1 
ATOM 3404 N N   . GLU A 1 447 ? 115.281 136.427 130.291 1.00 42.06 ? 490 GLU A N   1 
ATOM 3405 C CA  . GLU A 1 447 ? 114.637 137.737 130.264 1.00 45.12 ? 490 GLU A CA  1 
ATOM 3406 C C   . GLU A 1 447 ? 115.000 138.508 129.000 1.00 50.68 ? 490 GLU A C   1 
ATOM 3407 O O   . GLU A 1 447 ? 114.125 139.091 128.347 1.00 59.43 ? 490 GLU A O   1 
ATOM 3408 C CB  . GLU A 1 447 ? 115.020 138.534 131.509 1.00 47.83 ? 490 GLU A CB  1 
ATOM 3409 C CG  . GLU A 1 447 ? 114.354 138.045 132.781 1.00 50.89 ? 490 GLU A CG  1 
ATOM 3410 C CD  . GLU A 1 447 ? 112.930 138.542 132.919 1.00 55.92 ? 490 GLU A CD  1 
ATOM 3411 O OE1 . GLU A 1 447 ? 112.708 139.762 132.772 1.00 59.21 ? 490 GLU A OE1 1 
ATOM 3412 O OE2 . GLU A 1 447 ? 112.031 137.713 133.173 1.00 55.59 ? 490 GLU A OE2 1 
ATOM 3413 N N   . ILE A 1 448 ? 116.285 138.513 128.634 1.00 40.03 ? 491 ILE A N   1 
ATOM 3414 C CA  . ILE A 1 448 ? 116.712 139.192 127.413 1.00 39.63 ? 491 ILE A CA  1 
ATOM 3415 C C   . ILE A 1 448 ? 116.049 138.558 126.199 1.00 43.76 ? 491 ILE A C   1 
ATOM 3416 O O   . ILE A 1 448 ? 115.511 139.254 125.322 1.00 51.71 ? 491 ILE A O   1 
ATOM 3417 C CB  . ILE A 1 448 ? 118.246 139.168 127.294 1.00 36.92 ? 491 ILE A CB  1 
ATOM 3418 C CG1 . ILE A 1 448 ? 118.876 140.198 128.232 1.00 49.14 ? 491 ILE A CG1 1 
ATOM 3419 C CG2 . ILE A 1 448 ? 118.680 139.425 125.860 1.00 42.05 ? 491 ILE A CG2 1 
ATOM 3420 C CD1 . ILE A 1 448 ? 120.376 140.317 128.082 1.00 49.25 ? 491 ILE A CD1 1 
ATOM 3421 N N   . TYR A 1 449 ? 116.067 137.222 126.135 1.00 38.32 ? 492 TYR A N   1 
ATOM 3422 C CA  . TYR A 1 449 ? 115.456 136.547 124.992 1.00 41.40 ? 492 TYR A CA  1 
ATOM 3423 C C   . TYR A 1 449 ? 113.963 136.850 124.900 1.00 44.89 ? 492 TYR A C   1 
ATOM 3424 O O   . TYR A 1 449 ? 113.443 137.133 123.812 1.00 48.77 ? 492 TYR A O   1 
ATOM 3425 C CB  . TYR A 1 449 ? 115.696 135.041 125.080 1.00 45.24 ? 492 TYR A CB  1 
ATOM 3426 C CG  . TYR A 1 449 ? 117.154 134.653 125.026 1.00 46.25 ? 492 TYR A CG  1 
ATOM 3427 C CD1 . TYR A 1 449 ? 118.027 135.281 124.148 1.00 48.36 ? 492 TYR A CD1 1 
ATOM 3428 C CD2 . TYR A 1 449 ? 117.660 133.661 125.853 1.00 47.29 ? 492 TYR A CD2 1 
ATOM 3429 C CE1 . TYR A 1 449 ? 119.361 134.931 124.096 1.00 47.37 ? 492 TYR A CE1 1 
ATOM 3430 C CE2 . TYR A 1 449 ? 118.993 133.304 125.807 1.00 47.47 ? 492 TYR A CE2 1 
ATOM 3431 C CZ  . TYR A 1 449 ? 119.838 133.943 124.928 1.00 46.03 ? 492 TYR A CZ  1 
ATOM 3432 O OH  . TYR A 1 449 ? 121.166 133.593 124.878 1.00 49.11 ? 492 TYR A OH  1 
ATOM 3433 N N   . ARG A 1 450 ? 113.263 136.812 126.036 1.00 39.43 ? 493 ARG A N   1 
ATOM 3434 C CA  . ARG A 1 450 ? 111.828 137.062 126.055 1.00 34.97 ? 493 ARG A CA  1 
ATOM 3435 C C   . ARG A 1 450 ? 111.503 138.482 125.622 1.00 41.63 ? 493 ARG A C   1 
ATOM 3436 O O   . ARG A 1 450 ? 110.559 138.701 124.857 1.00 53.42 ? 493 ARG A O   1 
ATOM 3437 C CB  . ARG A 1 450 ? 111.280 136.795 127.455 1.00 33.61 ? 493 ARG A CB  1 
ATOM 3438 C CG  . ARG A 1 450 ? 109.777 136.912 127.573 1.00 41.16 ? 493 ARG A CG  1 
ATOM 3439 C CD  . ARG A 1 450 ? 109.338 136.726 129.012 1.00 42.79 ? 493 ARG A CD  1 
ATOM 3440 N NE  . ARG A 1 450 ? 110.078 137.596 129.916 1.00 35.19 ? 493 ARG A NE  1 
ATOM 3441 C CZ  . ARG A 1 450 ? 109.638 138.766 130.357 1.00 46.32 ? 493 ARG A CZ  1 
ATOM 3442 N NH1 . ARG A 1 450 ? 108.457 139.240 129.996 1.00 46.96 ? 493 ARG A NH1 1 
ATOM 3443 N NH2 . ARG A 1 450 ? 110.402 139.479 131.179 1.00 49.32 ? 493 ARG A NH2 1 
ATOM 3444 N N   . VAL A 1 451 ? 112.267 139.463 126.106 1.00 39.98 ? 494 VAL A N   1 
ATOM 3445 C CA  . VAL A 1 451 ? 111.999 140.850 125.742 1.00 35.99 ? 494 VAL A CA  1 
ATOM 3446 C C   . VAL A 1 451 ? 112.224 141.069 124.250 1.00 41.75 ? 494 VAL A C   1 
ATOM 3447 O O   . VAL A 1 451 ? 111.406 141.707 123.568 1.00 44.06 ? 494 VAL A O   1 
ATOM 3448 C CB  . VAL A 1 451 ? 112.860 141.795 126.597 1.00 39.59 ? 494 VAL A CB  1 
ATOM 3449 C CG1 . VAL A 1 451 ? 113.059 143.114 125.887 1.00 46.20 ? 494 VAL A CG1 1 
ATOM 3450 C CG2 . VAL A 1 451 ? 112.214 142.009 127.955 1.00 40.29 ? 494 VAL A CG2 1 
ATOM 3451 N N   . SER A 1 452 ? 113.328 140.536 123.715 1.00 41.31 ? 495 SER A N   1 
ATOM 3452 C CA  . SER A 1 452 ? 113.583 140.688 122.286 1.00 31.43 ? 495 SER A CA  1 
ATOM 3453 C C   . SER A 1 452 ? 112.486 140.032 121.457 1.00 40.67 ? 495 SER A C   1 
ATOM 3454 O O   . SER A 1 452 ? 112.010 140.612 120.470 1.00 52.61 ? 495 SER A O   1 
ATOM 3455 C CB  . SER A 1 452 ? 114.949 140.105 121.930 1.00 34.81 ? 495 SER A CB  1 
ATOM 3456 O OG  . SER A 1 452 ? 115.993 140.897 122.464 1.00 43.91 ? 495 SER A OG  1 
ATOM 3457 N N   . TYR A 1 453 ? 112.055 138.829 121.848 1.00 48.52 ? 496 TYR A N   1 
ATOM 3458 C CA  . TYR A 1 453 ? 111.011 138.152 121.086 1.00 47.71 ? 496 TYR A CA  1 
ATOM 3459 C C   . TYR A 1 453 ? 109.680 138.886 121.188 1.00 48.53 ? 496 TYR A C   1 
ATOM 3460 O O   . TYR A 1 453 ? 108.910 138.914 120.224 1.00 52.41 ? 496 TYR A O   1 
ATOM 3461 C CB  . TYR A 1 453 ? 110.856 136.706 121.549 1.00 49.36 ? 496 TYR A CB  1 
ATOM 3462 C CG  . TYR A 1 453 ? 109.928 135.912 120.662 1.00 45.53 ? 496 TYR A CG  1 
ATOM 3463 C CD1 . TYR A 1 453 ? 110.188 135.773 119.306 1.00 44.78 ? 496 TYR A CD1 1 
ATOM 3464 C CD2 . TYR A 1 453 ? 108.788 135.313 121.173 1.00 44.44 ? 496 TYR A CD2 1 
ATOM 3465 C CE1 . TYR A 1 453 ? 109.345 135.056 118.487 1.00 44.59 ? 496 TYR A CE1 1 
ATOM 3466 C CE2 . TYR A 1 453 ? 107.937 134.592 120.361 1.00 46.80 ? 496 TYR A CE2 1 
ATOM 3467 C CZ  . TYR A 1 453 ? 108.221 134.467 119.019 1.00 47.87 ? 496 TYR A CZ  1 
ATOM 3468 O OH  . TYR A 1 453 ? 107.376 133.749 118.205 1.00 52.42 ? 496 TYR A OH  1 
ATOM 3469 N N   . GLU A 1 454 ? 109.381 139.467 122.352 1.00 38.73 ? 497 GLU A N   1 
ATOM 3470 C CA  . GLU A 1 454 ? 108.151 140.238 122.491 1.00 31.09 ? 497 GLU A CA  1 
ATOM 3471 C C   . GLU A 1 454 ? 108.160 141.451 121.573 1.00 39.40 ? 497 GLU A C   1 
ATOM 3472 O O   . GLU A 1 454 ? 107.149 141.759 120.931 1.00 52.17 ? 497 GLU A O   1 
ATOM 3473 C CB  . GLU A 1 454 ? 107.959 140.667 123.944 1.00 37.39 ? 497 GLU A CB  1 
ATOM 3474 C CG  . GLU A 1 454 ? 107.363 139.594 124.833 1.00 39.58 ? 497 GLU A CG  1 
ATOM 3475 C CD  . GLU A 1 454 ? 107.357 139.992 126.294 1.00 50.42 ? 497 GLU A CD  1 
ATOM 3476 O OE1 . GLU A 1 454 ? 107.898 141.069 126.618 1.00 49.98 ? 497 GLU A OE1 1 
ATOM 3477 O OE2 . GLU A 1 454 ? 106.814 139.227 127.118 1.00 54.13 ? 497 GLU A OE2 1 
ATOM 3478 N N   . ALA A 1 455 ? 109.295 142.151 121.493 1.00 40.11 ? 498 ALA A N   1 
ATOM 3479 C CA  . ALA A 1 455 ? 109.388 143.275 120.563 1.00 37.03 ? 498 ALA A CA  1 
ATOM 3480 C C   . ALA A 1 455 ? 109.214 142.811 119.120 1.00 38.48 ? 498 ALA A C   1 
ATOM 3481 O O   . ALA A 1 455 ? 108.492 143.443 118.334 1.00 40.04 ? 498 ALA A O   1 
ATOM 3482 C CB  . ALA A 1 455 ? 110.722 143.996 120.740 1.00 42.71 ? 498 ALA A CB  1 
ATOM 3483 N N   . MET A 1 456 ? 109.856 141.696 118.761 1.00 39.13 ? 499 MET A N   1 
ATOM 3484 C CA  . MET A 1 456 ? 109.734 141.165 117.407 1.00 34.22 ? 499 MET A CA  1 
ATOM 3485 C C   . MET A 1 456 ? 108.285 140.829 117.076 1.00 38.86 ? 499 MET A C   1 
ATOM 3486 O O   . MET A 1 456 ? 107.792 141.149 115.988 1.00 48.45 ? 499 MET A O   1 
ATOM 3487 C CB  . MET A 1 456 ? 110.617 139.928 117.254 1.00 38.12 ? 499 MET A CB  1 
ATOM 3488 C CG  . MET A 1 456 ? 112.103 140.213 117.300 1.00 42.93 ? 499 MET A CG  1 
ATOM 3489 S SD  . MET A 1 456 ? 113.084 138.703 117.288 1.00 56.40 ? 499 MET A SD  1 
ATOM 3490 C CE  . MET A 1 456 ? 114.559 139.257 118.136 1.00 48.28 ? 499 MET A CE  1 
ATOM 3491 N N   . VAL A 1 457 ? 107.588 140.176 118.007 1.00 42.08 ? 500 VAL A N   1 
ATOM 3492 C CA  . VAL A 1 457 ? 106.195 139.804 117.782 1.00 38.71 ? 500 VAL A CA  1 
ATOM 3493 C C   . VAL A 1 457 ? 105.325 141.047 117.657 1.00 39.70 ? 500 VAL A C   1 
ATOM 3494 O O   . VAL A 1 457 ? 104.449 141.125 116.787 1.00 45.20 ? 500 VAL A O   1 
ATOM 3495 C CB  . VAL A 1 457 ? 105.705 138.874 118.909 1.00 42.38 ? 500 VAL A CB  1 
ATOM 3496 C CG1 . VAL A 1 457 ? 104.188 138.890 119.001 1.00 41.50 ? 500 VAL A CG1 1 
ATOM 3497 C CG2 . VAL A 1 457 ? 106.215 137.461 118.687 1.00 41.75 ? 500 VAL A CG2 1 
ATOM 3498 N N   . ALA A 1 458 ? 105.555 142.040 118.520 1.00 42.75 ? 501 ALA A N   1 
ATOM 3499 C CA  . ALA A 1 458 ? 104.776 143.271 118.455 1.00 38.86 ? 501 ALA A CA  1 
ATOM 3500 C C   . ALA A 1 458 ? 104.959 143.979 117.122 1.00 38.04 ? 501 ALA A C   1 
ATOM 3501 O O   . ALA A 1 458 ? 104.020 144.608 116.621 1.00 41.65 ? 501 ALA A O   1 
ATOM 3502 C CB  . ALA A 1 458 ? 105.158 144.199 119.607 1.00 45.00 ? 501 ALA A CB  1 
ATOM 3503 N N   . ASN A 1 459 ? 106.152 143.895 116.530 1.00 43.24 ? 502 ASN A N   1 
ATOM 3504 C CA  . ASN A 1 459 ? 106.336 144.500 115.214 1.00 36.07 ? 502 ASN A CA  1 
ATOM 3505 C C   . ASN A 1 459 ? 105.707 143.669 114.098 1.00 44.57 ? 502 ASN A C   1 
ATOM 3506 O O   . ASN A 1 459 ? 105.233 144.237 113.108 1.00 50.77 ? 502 ASN A O   1 
ATOM 3507 C CB  . ASN A 1 459 ? 107.821 144.722 114.936 1.00 38.52 ? 502 ASN A CB  1 
ATOM 3508 C CG  . ASN A 1 459 ? 108.354 145.973 115.600 1.00 43.67 ? 502 ASN A CG  1 
ATOM 3509 O OD1 . ASN A 1 459 ? 108.045 147.089 115.184 1.00 48.55 ? 502 ASN A OD1 1 
ATOM 3510 N ND2 . ASN A 1 459 ? 109.160 145.795 116.638 1.00 50.54 ? 502 ASN A ND2 1 
ATOM 3511 N N   . ASP A 1 460 ? 105.690 142.340 114.231 1.00 52.37 ? 503 ASP A N   1 
ATOM 3512 C CA  . ASP A 1 460 ? 105.101 141.470 113.216 1.00 49.71 ? 503 ASP A CA  1 
ATOM 3513 C C   . ASP A 1 460 ? 104.723 140.123 113.822 1.00 48.09 ? 503 ASP A C   1 
ATOM 3514 O O   . ASP A 1 460 ? 105.565 139.468 114.449 1.00 51.88 ? 503 ASP A O   1 
ATOM 3515 C CB  . ASP A 1 460 ? 106.068 141.272 112.048 1.00 54.55 ? 503 ASP A CB  1 
ATOM 3516 C CG  . ASP A 1 460 ? 105.356 140.991 110.739 1.00 59.36 ? 503 ASP A CG  1 
ATOM 3517 O OD1 . ASP A 1 460 ? 104.185 141.400 110.596 1.00 57.90 ? 503 ASP A OD1 1 
ATOM 3518 O OD2 . ASP A 1 460 ? 105.969 140.360 109.852 1.00 54.44 ? 503 ASP A OD2 1 
ATOM 3519 N N   . PRO A 1 461 ? 103.471 139.682 113.669 1.00 42.22 ? 504 PRO A N   1 
ATOM 3520 C CA  . PRO A 1 461 ? 103.071 138.391 114.256 1.00 41.70 ? 504 PRO A CA  1 
ATOM 3521 C C   . PRO A 1 461 ? 103.850 137.204 113.721 1.00 45.39 ? 504 PRO A C   1 
ATOM 3522 O O   . PRO A 1 461 ? 104.095 136.250 114.470 1.00 47.94 ? 504 PRO A O   1 
ATOM 3523 C CB  . PRO A 1 461 ? 101.581 138.294 113.901 1.00 43.81 ? 504 PRO A CB  1 
ATOM 3524 C CG  . PRO A 1 461 ? 101.153 139.699 113.649 1.00 51.30 ? 504 PRO A CG  1 
ATOM 3525 C CD  . PRO A 1 461 ? 102.338 140.372 113.032 1.00 49.04 ? 504 PRO A CD  1 
ATOM 3526 N N   . ASN A 1 462 ? 104.244 137.225 112.451 1.00 49.42 ? 505 ASN A N   1 
ATOM 3527 C CA  . ASN A 1 462 ? 105.014 136.144 111.845 1.00 44.91 ? 505 ASN A CA  1 
ATOM 3528 C C   . ASN A 1 462 ? 106.472 136.580 111.770 1.00 45.08 ? 505 ASN A C   1 
ATOM 3529 O O   . ASN A 1 462 ? 106.832 137.431 110.951 1.00 55.03 ? 505 ASN A O   1 
ATOM 3530 C CB  . ASN A 1 462 ? 104.473 135.796 110.461 1.00 45.09 ? 505 ASN A CB  1 
ATOM 3531 C CG  . ASN A 1 462 ? 102.968 135.631 110.447 1.00 51.26 ? 505 ASN A CG  1 
ATOM 3532 O OD1 . ASN A 1 462 ? 102.291 136.086 109.527 1.00 53.11 ? 505 ASN A OD1 1 
ATOM 3533 N ND2 . ASN A 1 462 ? 102.435 134.972 111.470 1.00 52.04 ? 505 ASN A ND2 1 
ATOM 3534 N N   . VAL A 1 463 ? 107.309 135.994 112.625 1.00 41.40 ? 506 VAL A N   1 
ATOM 3535 C CA  . VAL A 1 463 ? 108.716 136.351 112.710 1.00 38.77 ? 506 VAL A CA  1 
ATOM 3536 C C   . VAL A 1 463 ? 109.553 135.081 112.730 1.00 50.32 ? 506 VAL A C   1 
ATOM 3537 O O   . VAL A 1 463 ? 109.070 133.992 113.048 1.00 57.21 ? 506 VAL A O   1 
ATOM 3538 C CB  . VAL A 1 463 ? 109.023 137.209 113.953 1.00 44.15 ? 506 VAL A CB  1 
ATOM 3539 C CG1 . VAL A 1 463 ? 108.692 138.657 113.683 1.00 44.30 ? 506 VAL A CG1 1 
ATOM 3540 C CG2 . VAL A 1 463 ? 108.246 136.695 115.154 1.00 51.94 ? 506 VAL A CG2 1 
ATOM 3541 N N   . PHE A 1 464 ? 110.826 135.237 112.385 1.00 51.11 ? 507 PHE A N   1 
ATOM 3542 C CA  . PHE A 1 464 ? 111.799 134.156 112.431 1.00 48.73 ? 507 PHE A CA  1 
ATOM 3543 C C   . PHE A 1 464 ? 112.785 134.421 113.559 1.00 53.87 ? 507 PHE A C   1 
ATOM 3544 O O   . PHE A 1 464 ? 113.403 135.490 113.609 1.00 54.16 ? 507 PHE A O   1 
ATOM 3545 C CB  . PHE A 1 464 ? 112.535 134.026 111.097 1.00 46.46 ? 507 PHE A CB  1 
ATOM 3546 C CG  . PHE A 1 464 ? 113.406 132.808 111.001 1.00 52.68 ? 507 PHE A CG  1 
ATOM 3547 C CD1 . PHE A 1 464 ? 114.739 132.863 111.367 1.00 53.10 ? 507 PHE A CD1 1 
ATOM 3548 C CD2 . PHE A 1 464 ? 112.892 131.609 110.542 1.00 51.44 ? 507 PHE A CD2 1 
ATOM 3549 C CE1 . PHE A 1 464 ? 115.541 131.746 111.279 1.00 54.94 ? 507 PHE A CE1 1 
ATOM 3550 C CE2 . PHE A 1 464 ? 113.690 130.489 110.451 1.00 51.25 ? 507 PHE A CE2 1 
ATOM 3551 C CZ  . PHE A 1 464 ? 115.017 130.557 110.821 1.00 54.24 ? 507 PHE A CZ  1 
ATOM 3552 N N   . ASN A 1 465 ? 112.930 133.452 114.461 1.00 55.81 ? 508 ASN A N   1 
ATOM 3553 C CA  . ASN A 1 465 ? 113.831 133.578 115.600 1.00 53.36 ? 508 ASN A CA  1 
ATOM 3554 C C   . ASN A 1 465 ? 114.562 132.260 115.799 1.00 54.96 ? 508 ASN A C   1 
ATOM 3555 O O   . ASN A 1 465 ? 113.938 131.246 116.125 1.00 55.45 ? 508 ASN A O   1 
ATOM 3556 C CB  . ASN A 1 465 ? 113.069 133.966 116.870 1.00 47.42 ? 508 ASN A CB  1 
ATOM 3557 C CG  . ASN A 1 465 ? 113.878 134.865 117.780 1.00 53.67 ? 508 ASN A CG  1 
ATOM 3558 O OD1 . ASN A 1 465 ? 114.966 135.311 117.421 1.00 57.67 ? 508 ASN A OD1 1 
ATOM 3559 N ND2 . ASN A 1 465 ? 113.350 135.136 118.966 1.00 55.22 ? 508 ASN A ND2 1 
ATOM 3560 N N   . LEU A 1 466 ? 115.880 132.279 115.606 1.00 59.08 ? 509 LEU A N   1 
ATOM 3561 C CA  . LEU A 1 466 ? 116.718 131.101 115.766 1.00 59.35 ? 509 LEU A CA  1 
ATOM 3562 C C   . LEU A 1 466 ? 117.979 131.485 116.526 1.00 65.12 ? 509 LEU A C   1 
ATOM 3563 O O   . LEU A 1 466 ? 118.553 132.551 116.290 1.00 63.40 ? 509 LEU A O   1 
ATOM 3564 C CB  . LEU A 1 466 ? 117.076 130.488 114.404 1.00 55.59 ? 509 LEU A CB  1 
ATOM 3565 C CG  . LEU A 1 466 ? 118.364 129.671 114.271 1.00 60.36 ? 509 LEU A CG  1 
ATOM 3566 C CD1 . LEU A 1 466 ? 118.252 128.343 115.002 1.00 58.63 ? 509 LEU A CD1 1 
ATOM 3567 C CD2 . LEU A 1 466 ? 118.704 129.449 112.805 1.00 62.12 ? 509 LEU A CD2 1 
ATOM 3568 N N   . LEU A 1 467 ? 118.404 130.611 117.437 1.00 60.99 ? 510 LEU A N   1 
ATOM 3569 C CA  . LEU A 1 467 ? 119.590 130.826 118.255 1.00 56.19 ? 510 LEU A CA  1 
ATOM 3570 C C   . LEU A 1 467 ? 120.565 129.678 118.038 1.00 61.01 ? 510 LEU A C   1 
ATOM 3571 O O   . LEU A 1 467 ? 120.167 128.510 118.072 1.00 65.76 ? 510 LEU A O   1 
ATOM 3572 C CB  . LEU A 1 467 ? 119.222 130.933 119.737 1.00 56.01 ? 510 LEU A CB  1 
ATOM 3573 C CG  . LEU A 1 467 ? 120.307 131.421 120.698 1.00 60.35 ? 510 LEU A CG  1 
ATOM 3574 C CD1 . LEU A 1 467 ? 120.710 132.850 120.382 1.00 58.08 ? 510 LEU A CD1 1 
ATOM 3575 C CD2 . LEU A 1 467 ? 119.837 131.302 122.138 1.00 60.06 ? 510 LEU A CD2 1 
ATOM 3576 N N   . CYS A 1 468 ? 121.833 130.009 117.808 1.00 60.13 ? 511 CYS A N   1 
ATOM 3577 C CA  . CYS A 1 468 ? 122.886 129.013 117.621 1.00 52.19 ? 511 CYS A CA  1 
ATOM 3578 C C   . CYS A 1 468 ? 123.859 129.104 118.790 1.00 56.88 ? 511 CYS A C   1 
ATOM 3579 O O   . CYS A 1 468 ? 124.733 129.975 118.816 1.00 59.15 ? 511 CYS A O   1 
ATOM 3580 C CB  . CYS A 1 468 ? 123.618 129.207 116.295 1.00 51.37 ? 511 CYS A CB  1 
ATOM 3581 S SG  . CYS A 1 468 ? 124.960 128.006 116.006 1.00 65.92 ? 511 CYS A SG  1 
ATOM 3582 N N   . ASN A 1 469 ? 123.705 128.200 119.758 1.00 50.72 ? 512 ASN A N   1 
ATOM 3583 C CA  . ASN A 1 469 ? 124.745 127.954 120.755 1.00 48.09 ? 512 ASN A CA  1 
ATOM 3584 C C   . ASN A 1 469 ? 125.780 127.033 120.110 1.00 50.17 ? 512 ASN A C   1 
ATOM 3585 O O   . ASN A 1 469 ? 125.966 125.874 120.485 1.00 52.06 ? 512 ASN A O   1 
ATOM 3586 C CB  . ASN A 1 469 ? 124.151 127.354 122.021 1.00 49.97 ? 512 ASN A CB  1 
ATOM 3587 C CG  . ASN A 1 469 ? 123.443 128.384 122.877 1.00 50.32 ? 512 ASN A CG  1 
ATOM 3588 O OD1 . ASN A 1 469 ? 122.265 128.236 123.199 1.00 54.37 ? 512 ASN A OD1 1 
ATOM 3589 N ND2 . ASN A 1 469 ? 124.159 129.436 123.249 1.00 48.58 ? 512 ASN A ND2 1 
ATOM 3590 N N   . CYS A 1 470 ? 126.461 127.590 119.108 1.00 49.92 ? 513 CYS A N   1 
ATOM 3591 C CA  . CYS A 1 470 ? 127.210 126.821 118.122 1.00 51.14 ? 513 CYS A CA  1 
ATOM 3592 C C   . CYS A 1 470 ? 128.283 125.944 118.757 1.00 47.89 ? 513 CYS A C   1 
ATOM 3593 O O   . CYS A 1 470 ? 129.250 126.448 119.336 1.00 51.09 ? 513 CYS A O   1 
ATOM 3594 C CB  . CYS A 1 470 ? 127.830 127.768 117.091 1.00 49.11 ? 513 CYS A CB  1 
ATOM 3595 S SG  . CYS A 1 470 ? 126.681 129.014 116.416 1.00 54.77 ? 513 CYS A SG  1 
ATOM 3596 N N   . GLY A 1 471 ? 128.112 124.629 118.647 1.00 42.55 ? 514 GLY A N   1 
ATOM 3597 C CA  . GLY A 1 471 ? 129.069 123.679 119.175 1.00 44.92 ? 514 GLY A CA  1 
ATOM 3598 C C   . GLY A 1 471 ? 128.502 122.799 120.269 1.00 44.66 ? 514 GLY A C   1 
ATOM 3599 O O   . GLY A 1 471 ? 128.755 121.592 120.302 1.00 50.15 ? 514 GLY A O   1 
ATOM 3600 N N   . THR A 1 472 ? 127.724 123.388 121.159 1.00 45.19 ? 515 THR A N   1 
ATOM 3601 C CA  . THR A 1 472 ? 127.150 122.720 122.311 1.00 40.20 ? 515 THR A CA  1 
ATOM 3602 C C   . THR A 1 472 ? 125.642 122.590 122.156 1.00 37.06 ? 515 THR A C   1 
ATOM 3603 O O   . THR A 1 472 ? 125.036 123.227 121.288 1.00 49.67 ? 515 THR A O   1 
ATOM 3604 C CB  . THR A 1 472 ? 127.478 123.502 123.588 1.00 45.97 ? 515 THR A CB  1 
ATOM 3605 O OG1 . THR A 1 472 ? 126.882 124.803 123.520 1.00 53.00 ? 515 THR A OG1 1 
ATOM 3606 C CG2 . THR A 1 472 ? 128.981 123.650 123.748 1.00 47.48 ? 515 THR A CG2 1 
ATOM 3607 N N   . PRO A 1 473 ? 125.001 121.749 122.966 1.00 41.51 ? 516 PRO A N   1 
ATOM 3608 C CA  . PRO A 1 473 ? 123.536 121.725 122.977 1.00 44.29 ? 516 PRO A CA  1 
ATOM 3609 C C   . PRO A 1 473 ? 122.975 123.094 123.334 1.00 50.58 ? 516 PRO A C   1 
ATOM 3610 O O   . PRO A 1 473 ? 123.521 123.809 124.178 1.00 55.78 ? 516 PRO A O   1 
ATOM 3611 C CB  . PRO A 1 473 ? 123.209 120.680 124.046 1.00 47.84 ? 516 PRO A CB  1 
ATOM 3612 C CG  . PRO A 1 473 ? 124.377 119.775 124.043 1.00 50.41 ? 516 PRO A CG  1 
ATOM 3613 C CD  . PRO A 1 473 ? 125.569 120.640 123.754 1.00 55.09 ? 516 PRO A CD  1 
ATOM 3614 N N   . GLN A 1 474 ? 121.876 123.455 122.680 1.00 48.54 ? 517 GLN A N   1 
ATOM 3615 C CA  . GLN A 1 474 ? 121.347 124.805 122.798 1.00 56.50 ? 517 GLN A CA  1 
ATOM 3616 C C   . GLN A 1 474 ? 120.717 125.020 124.170 1.00 60.68 ? 517 GLN A C   1 
ATOM 3617 O O   . GLN A 1 474 ? 120.246 124.081 124.818 1.00 56.48 ? 517 GLN A O   1 
ATOM 3618 C CB  . GLN A 1 474 ? 120.327 125.071 121.689 1.00 56.08 ? 517 GLN A CB  1 
ATOM 3619 C CG  . GLN A 1 474 ? 119.885 126.520 121.565 1.00 55.20 ? 517 GLN A CG  1 
ATOM 3620 C CD  . GLN A 1 474 ? 118.727 126.696 120.607 1.00 62.54 ? 517 GLN A CD  1 
ATOM 3621 O OE1 . GLN A 1 474 ? 117.574 126.472 120.962 1.00 63.20 ? 517 GLN A OE1 1 
ATOM 3622 N NE2 . GLN A 1 474 ? 119.032 127.093 119.378 1.00 65.72 ? 517 GLN A NE2 1 
ATOM 3623 N N   . ASP A 1 475 ? 120.726 126.278 124.614 1.00 64.65 ? 518 ASP A N   1 
ATOM 3624 C CA  . ASP A 1 475 ? 120.195 126.631 125.924 1.00 55.89 ? 518 ASP A CA  1 
ATOM 3625 C C   . ASP A 1 475 ? 118.723 126.247 126.005 1.00 57.85 ? 518 ASP A C   1 
ATOM 3626 O O   . ASP A 1 475 ? 117.935 126.558 125.108 1.00 61.00 ? 518 ASP A O   1 
ATOM 3627 C CB  . ASP A 1 475 ? 120.381 128.133 126.165 1.00 60.76 ? 518 ASP A CB  1 
ATOM 3628 C CG  . ASP A 1 475 ? 119.879 128.594 127.531 1.00 63.13 ? 518 ASP A CG  1 
ATOM 3629 O OD1 . ASP A 1 475 ? 119.179 127.834 128.234 1.00 63.79 ? 518 ASP A OD1 1 
ATOM 3630 O OD2 . ASP A 1 475 ? 120.192 129.743 127.905 1.00 61.82 ? 518 ASP A OD2 1 
ATOM 3631 N N   . TYR A 1 476 ? 118.354 125.569 127.093 1.00 48.07 ? 519 TYR A N   1 
ATOM 3632 C CA  . TYR A 1 476 ? 116.994 125.057 127.213 1.00 48.28 ? 519 TYR A CA  1 
ATOM 3633 C C   . TYR A 1 476 ? 115.986 126.166 127.476 1.00 49.30 ? 519 TYR A C   1 
ATOM 3634 O O   . TYR A 1 476 ? 114.842 126.079 127.018 1.00 50.70 ? 519 TYR A O   1 
ATOM 3635 C CB  . TYR A 1 476 ? 116.915 124.008 128.320 1.00 43.64 ? 519 TYR A CB  1 
ATOM 3636 C CG  . TYR A 1 476 ? 115.595 123.275 128.347 1.00 38.09 ? 519 TYR A CG  1 
ATOM 3637 C CD1 . TYR A 1 476 ? 115.304 122.292 127.411 1.00 49.81 ? 519 TYR A CD1 1 
ATOM 3638 C CD2 . TYR A 1 476 ? 114.635 123.576 129.296 1.00 38.72 ? 519 TYR A CD2 1 
ATOM 3639 C CE1 . TYR A 1 476 ? 114.095 121.625 127.429 1.00 51.68 ? 519 TYR A CE1 1 
ATOM 3640 C CE2 . TYR A 1 476 ? 113.426 122.919 129.320 1.00 41.23 ? 519 TYR A CE2 1 
ATOM 3641 C CZ  . TYR A 1 476 ? 113.161 121.944 128.387 1.00 49.70 ? 519 TYR A CZ  1 
ATOM 3642 O OH  . TYR A 1 476 ? 111.954 121.286 128.414 1.00 53.91 ? 519 TYR A OH  1 
ATOM 3643 N N   . TYR A 1 477 ? 116.378 127.205 128.204 1.00 44.80 ? 520 TYR A N   1 
ATOM 3644 C CA  . TYR A 1 477 ? 115.443 128.252 128.586 1.00 38.01 ? 520 TYR A CA  1 
ATOM 3645 C C   . TYR A 1 477 ? 115.307 129.340 127.532 1.00 45.77 ? 520 TYR A C   1 
ATOM 3646 O O   . TYR A 1 477 ? 114.541 130.287 127.735 1.00 55.85 ? 520 TYR A O   1 
ATOM 3647 C CB  . TYR A 1 477 ? 115.855 128.851 129.931 1.00 38.82 ? 520 TYR A CB  1 
ATOM 3648 C CG  . TYR A 1 477 ? 115.823 127.827 131.038 1.00 39.49 ? 520 TYR A CG  1 
ATOM 3649 C CD1 . TYR A 1 477 ? 114.630 127.490 131.659 1.00 45.41 ? 520 TYR A CD1 1 
ATOM 3650 C CD2 . TYR A 1 477 ? 116.978 127.180 131.447 1.00 40.69 ? 520 TYR A CD2 1 
ATOM 3651 C CE1 . TYR A 1 477 ? 114.590 126.546 132.662 1.00 48.23 ? 520 TYR A CE1 1 
ATOM 3652 C CE2 . TYR A 1 477 ? 116.948 126.236 132.451 1.00 43.62 ? 520 TYR A CE2 1 
ATOM 3653 C CZ  . TYR A 1 477 ? 115.752 125.923 133.054 1.00 46.54 ? 520 TYR A CZ  1 
ATOM 3654 O OH  . TYR A 1 477 ? 115.715 124.983 134.056 1.00 51.26 ? 520 TYR A OH  1 
ATOM 3655 N N   . SER A 1 478 ? 116.025 129.228 126.418 1.00 44.86 ? 521 SER A N   1 
ATOM 3656 C CA  . SER A 1 478 ? 115.761 130.048 125.245 1.00 39.21 ? 521 SER A CA  1 
ATOM 3657 C C   . SER A 1 478 ? 114.812 129.373 124.266 1.00 45.00 ? 521 SER A C   1 
ATOM 3658 O O   . SER A 1 478 ? 114.393 130.011 123.295 1.00 51.97 ? 521 SER A O   1 
ATOM 3659 C CB  . SER A 1 478 ? 117.070 130.386 124.529 1.00 45.67 ? 521 SER A CB  1 
ATOM 3660 O OG  . SER A 1 478 ? 117.504 129.301 123.729 1.00 52.88 ? 521 SER A OG  1 
ATOM 3661 N N   . LEU A 1 479 ? 114.463 128.110 124.506 1.00 46.98 ? 522 LEU A N   1 
ATOM 3662 C CA  . LEU A 1 479 ? 113.601 127.378 123.582 1.00 41.55 ? 522 LEU A CA  1 
ATOM 3663 C C   . LEU A 1 479 ? 112.216 127.992 123.390 1.00 45.52 ? 522 LEU A C   1 
ATOM 3664 O O   . LEU A 1 479 ? 111.773 128.075 122.231 1.00 56.28 ? 522 LEU A O   1 
ATOM 3665 C CB  . LEU A 1 479 ? 113.475 125.920 124.043 1.00 45.25 ? 522 LEU A CB  1 
ATOM 3666 C CG  . LEU A 1 479 ? 114.700 125.012 123.924 1.00 46.76 ? 522 LEU A CG  1 
ATOM 3667 C CD1 . LEU A 1 479 ? 114.335 123.583 124.284 1.00 47.60 ? 522 LEU A CD1 1 
ATOM 3668 C CD2 . LEU A 1 479 ? 115.278 125.071 122.530 1.00 43.81 ? 522 LEU A CD2 1 
ATOM 3669 N N   . PRO A 1 480 ? 111.485 128.418 124.429 1.00 36.62 ? 523 PRO A N   1 
ATOM 3670 C CA  . PRO A 1 480 ? 110.098 128.863 124.204 1.00 38.37 ? 523 PRO A CA  1 
ATOM 3671 C C   . PRO A 1 480 ? 109.963 130.059 123.279 1.00 40.12 ? 523 PRO A C   1 
ATOM 3672 O O   . PRO A 1 480 ? 108.862 130.304 122.774 1.00 49.41 ? 523 PRO A O   1 
ATOM 3673 C CB  . PRO A 1 480 ? 109.603 129.201 125.617 1.00 40.41 ? 523 PRO A CB  1 
ATOM 3674 C CG  . PRO A 1 480 ? 110.468 128.426 126.520 1.00 40.21 ? 523 PRO A CG  1 
ATOM 3675 C CD  . PRO A 1 480 ? 111.810 128.397 125.867 1.00 41.97 ? 523 PRO A CD  1 
ATOM 3676 N N   . TYR A 1 481 ? 111.034 130.815 123.041 1.00 41.08 ? 524 TYR A N   1 
ATOM 3677 C CA  . TYR A 1 481 ? 110.962 132.034 122.247 1.00 47.74 ? 524 TYR A CA  1 
ATOM 3678 C C   . TYR A 1 481 ? 111.551 131.865 120.850 1.00 50.13 ? 524 TYR A C   1 
ATOM 3679 O O   . TYR A 1 481 ? 111.838 132.862 120.181 1.00 53.27 ? 524 TYR A O   1 
ATOM 3680 C CB  . TYR A 1 481 ? 111.658 133.177 122.985 1.00 48.72 ? 524 TYR A CB  1 
ATOM 3681 C CG  . TYR A 1 481 ? 111.355 133.202 124.465 1.00 44.80 ? 524 TYR A CG  1 
ATOM 3682 C CD1 . TYR A 1 481 ? 110.073 133.459 124.924 1.00 45.29 ? 524 TYR A CD1 1 
ATOM 3683 C CD2 . TYR A 1 481 ? 112.349 132.960 125.401 1.00 45.81 ? 524 TYR A CD2 1 
ATOM 3684 C CE1 . TYR A 1 481 ? 109.789 133.478 126.274 1.00 42.13 ? 524 TYR A CE1 1 
ATOM 3685 C CE2 . TYR A 1 481 ? 112.074 132.978 126.753 1.00 46.91 ? 524 TYR A CE2 1 
ATOM 3686 C CZ  . TYR A 1 481 ? 110.792 133.238 127.183 1.00 47.51 ? 524 TYR A CZ  1 
ATOM 3687 O OH  . TYR A 1 481 ? 110.512 133.257 128.529 1.00 48.42 ? 524 TYR A OH  1 
ATOM 3688 N N   . MET A 1 482 ? 111.730 130.631 120.391 1.00 49.02 ? 525 MET A N   1 
ATOM 3689 C CA  . MET A 1 482 ? 112.269 130.360 119.068 1.00 43.11 ? 525 MET A CA  1 
ATOM 3690 C C   . MET A 1 482 ? 111.186 129.826 118.140 1.00 46.06 ? 525 MET A C   1 
ATOM 3691 O O   . MET A 1 482 ? 110.121 129.380 118.575 1.00 44.53 ? 525 MET A O   1 
ATOM 3692 C CB  . MET A 1 482 ? 113.424 129.354 119.127 1.00 49.29 ? 525 MET A CB  1 
ATOM 3693 C CG  . MET A 1 482 ? 114.461 129.604 120.206 1.00 55.79 ? 525 MET A CG  1 
ATOM 3694 S SD  . MET A 1 482 ? 115.631 130.916 119.800 1.00 55.07 ? 525 MET A SD  1 
ATOM 3695 C CE  . MET A 1 482 ? 114.944 132.304 120.694 1.00 46.86 ? 525 MET A CE  1 
ATOM 3696 N N   . THR A 1 483 ? 111.481 129.882 116.840 1.00 50.60 ? 526 THR A N   1 
ATOM 3697 C CA  . THR A 1 483 ? 110.645 129.280 115.814 1.00 45.36 ? 526 THR A CA  1 
ATOM 3698 C C   . THR A 1 483 ? 111.369 128.242 114.970 1.00 51.46 ? 526 THR A C   1 
ATOM 3699 O O   . THR A 1 483 ? 110.703 127.462 114.281 1.00 55.57 ? 526 THR A O   1 
ATOM 3700 C CB  . THR A 1 483 ? 110.073 130.360 114.881 1.00 49.42 ? 526 THR A CB  1 
ATOM 3701 O OG1 . THR A 1 483 ? 111.114 131.271 114.508 1.00 53.55 ? 526 THR A OG1 1 
ATOM 3702 C CG2 . THR A 1 483 ? 108.962 131.127 115.576 1.00 54.26 ? 526 THR A CG2 1 
ATOM 3703 N N   . GLN A 1 484 ? 112.700 128.208 115.005 1.00 55.40 ? 527 GLN A N   1 
ATOM 3704 C CA  . GLN A 1 484 ? 113.488 127.213 114.291 1.00 52.80 ? 527 GLN A CA  1 
ATOM 3705 C C   . GLN A 1 484 ? 114.718 126.886 115.124 1.00 55.79 ? 527 GLN A C   1 
ATOM 3706 O O   . GLN A 1 484 ? 115.206 127.725 115.886 1.00 61.36 ? 527 GLN A O   1 
ATOM 3707 C CB  . GLN A 1 484 ? 113.900 127.711 112.901 1.00 53.29 ? 527 GLN A CB  1 
ATOM 3708 C CG  . GLN A 1 484 ? 114.309 126.613 111.935 1.00 52.50 ? 527 GLN A CG  1 
ATOM 3709 C CD  . GLN A 1 484 ? 114.455 127.115 110.512 1.00 56.25 ? 527 GLN A CD  1 
ATOM 3710 O OE1 . GLN A 1 484 ? 115.545 127.492 110.084 1.00 57.53 ? 527 GLN A OE1 1 
ATOM 3711 N NE2 . GLN A 1 484 ? 113.355 127.122 109.772 1.00 56.77 ? 527 GLN A NE2 1 
ATOM 3712 N N   . ILE A 1 485 ? 115.214 125.657 114.982 1.00 47.30 ? 528 ILE A N   1 
ATOM 3713 C CA  . ILE A 1 485 ? 116.386 125.192 115.717 1.00 37.32 ? 528 ILE A CA  1 
ATOM 3714 C C   . ILE A 1 485 ? 117.384 124.587 114.743 1.00 40.12 ? 528 ILE A C   1 
ATOM 3715 O O   . ILE A 1 485 ? 117.006 123.808 113.861 1.00 48.76 ? 528 ILE A O   1 
ATOM 3716 C CB  . ILE A 1 485 ? 116.022 124.171 116.811 1.00 38.28 ? 528 ILE A CB  1 
ATOM 3717 C CG1 . ILE A 1 485 ? 114.872 124.698 117.667 1.00 44.49 ? 528 ILE A CG1 1 
ATOM 3718 C CG2 . ILE A 1 485 ? 117.240 123.847 117.663 1.00 46.89 ? 528 ILE A CG2 1 
ATOM 3719 C CD1 . ILE A 1 485 ? 114.837 124.122 119.052 1.00 47.04 ? 528 ILE A CD1 1 
ATOM 3720 N N   . ALA A 1 486 ? 118.654 124.945 114.907 1.00 43.27 ? 529 ALA A N   1 
ATOM 3721 C CA  . ALA A 1 486 ? 119.748 124.370 114.145 1.00 49.26 ? 529 ALA A CA  1 
ATOM 3722 C C   . ALA A 1 486 ? 120.469 123.321 114.988 1.00 53.29 ? 529 ALA A C   1 
ATOM 3723 O O   . ALA A 1 486 ? 120.136 123.080 116.151 1.00 58.37 ? 529 ALA A O   1 
ATOM 3724 C CB  . ALA A 1 486 ? 120.710 125.464 113.680 1.00 50.29 ? 529 ALA A CB  1 
ATOM 3725 N N   . THR A 1 487 ? 121.473 122.686 114.388 1.00 51.61 ? 530 THR A N   1 
ATOM 3726 C CA  . THR A 1 487 ? 122.246 121.646 115.050 1.00 49.15 ? 530 THR A CA  1 
ATOM 3727 C C   . THR A 1 487 ? 123.565 122.161 115.616 1.00 50.83 ? 530 THR A C   1 
ATOM 3728 O O   . THR A 1 487 ? 124.395 121.357 116.053 1.00 55.97 ? 530 THR A O   1 
ATOM 3729 C CB  . THR A 1 487 ? 122.501 120.486 114.088 1.00 45.20 ? 530 THR A CB  1 
ATOM 3730 O OG1 . THR A 1 487 ? 122.925 120.998 112.819 1.00 53.97 ? 530 THR A OG1 1 
ATOM 3731 C CG2 . THR A 1 487 ? 121.232 119.674 113.901 1.00 39.51 ? 530 THR A CG2 1 
ATOM 3732 N N   . ALA A 1 488 ? 123.775 123.479 115.607 1.00 46.15 ? 531 ALA A N   1 
ATOM 3733 C CA  . ALA A 1 488 ? 124.907 124.126 116.270 1.00 47.28 ? 531 ALA A CA  1 
ATOM 3734 C C   . ALA A 1 488 ? 126.246 123.633 115.716 1.00 48.63 ? 531 ALA A C   1 
ATOM 3735 O O   . ALA A 1 488 ? 127.096 123.111 116.438 1.00 55.39 ? 531 ALA A O   1 
ATOM 3736 C CB  . ALA A 1 488 ? 124.833 123.931 117.789 1.00 51.47 ? 531 ALA A CB  1 
ATOM 3737 N N   . ASP A 1 489 ? 126.418 123.828 114.412 1.00 48.21 ? 532 ASP A N   1 
ATOM 3738 C CA  . ASP A 1 489 ? 127.657 123.512 113.709 1.00 51.19 ? 532 ASP A CA  1 
ATOM 3739 C C   . ASP A 1 489 ? 128.182 122.106 114.014 1.00 53.88 ? 532 ASP A C   1 
ATOM 3740 O O   . ASP A 1 489 ? 129.267 121.954 114.588 1.00 55.33 ? 532 ASP A O   1 
ATOM 3741 C CB  . ASP A 1 489 ? 128.720 124.558 114.013 1.00 53.84 ? 532 ASP A CB  1 
ATOM 3742 C CG  . ASP A 1 489 ? 128.475 125.865 113.289 1.00 60.65 ? 532 ASP A CG  1 
ATOM 3743 O OD1 . ASP A 1 489 ? 127.628 125.888 112.372 1.00 58.72 ? 532 ASP A OD1 1 
ATOM 3744 O OD2 . ASP A 1 489 ? 129.133 126.869 113.633 1.00 61.15 ? 532 ASP A OD2 1 
ATOM 3745 N N   . PRO A 1 490 ? 127.440 121.063 113.652 1.00 47.04 ? 533 PRO A N   1 
ATOM 3746 C CA  . PRO A 1 490 ? 127.937 119.701 113.867 1.00 41.97 ? 533 PRO A CA  1 
ATOM 3747 C C   . PRO A 1 490 ? 129.137 119.406 112.984 1.00 48.22 ? 533 PRO A C   1 
ATOM 3748 O O   . PRO A 1 490 ? 129.268 119.929 111.875 1.00 56.95 ? 533 PRO A O   1 
ATOM 3749 C CB  . PRO A 1 490 ? 126.740 118.824 113.490 1.00 41.50 ? 533 PRO A CB  1 
ATOM 3750 C CG  . PRO A 1 490 ? 125.968 119.651 112.538 1.00 46.82 ? 533 PRO A CG  1 
ATOM 3751 C CD  . PRO A 1 490 ? 126.143 121.074 112.955 1.00 49.39 ? 533 PRO A CD  1 
ATOM 3752 N N   . THR A 1 491 ? 130.021 118.550 113.492 1.00 43.18 ? 534 THR A N   1 
ATOM 3753 C CA  . THR A 1 491 ? 131.235 118.199 112.765 1.00 38.94 ? 534 THR A CA  1 
ATOM 3754 C C   . THR A 1 491 ? 131.019 117.034 111.806 1.00 45.90 ? 534 THR A C   1 
ATOM 3755 O O   . THR A 1 491 ? 131.558 117.041 110.694 1.00 48.67 ? 534 THR A O   1 
ATOM 3756 C CB  . THR A 1 491 ? 132.358 117.867 113.752 1.00 43.56 ? 534 THR A CB  1 
ATOM 3757 O OG1 . THR A 1 491 ? 132.655 119.024 114.542 1.00 49.07 ? 534 THR A OG1 1 
ATOM 3758 C CG2 . THR A 1 491 ? 133.617 117.435 113.015 1.00 45.69 ? 534 THR A CG2 1 
ATOM 3759 N N   . SER A 1 492 ? 130.226 116.043 112.203 1.00 47.05 ? 535 SER A N   1 
ATOM 3760 C CA  . SER A 1 492 ? 129.986 114.863 111.388 1.00 41.61 ? 535 SER A CA  1 
ATOM 3761 C C   . SER A 1 492 ? 128.489 114.665 111.191 1.00 45.36 ? 535 SER A C   1 
ATOM 3762 O O   . SER A 1 492 ? 127.662 115.241 111.903 1.00 51.14 ? 535 SER A O   1 
ATOM 3763 C CB  . SER A 1 492 ? 130.610 113.612 112.017 1.00 47.90 ? 535 SER A CB  1 
ATOM 3764 O OG  . SER A 1 492 ? 131.997 113.794 112.242 1.00 55.09 ? 535 SER A OG  1 
ATOM 3765 N N   . VAL A 1 493 ? 128.153 113.835 110.202 1.00 44.56 ? 536 VAL A N   1 
ATOM 3766 C CA  . VAL A 1 493 ? 126.760 113.662 109.799 1.00 43.07 ? 536 VAL A CA  1 
ATOM 3767 C C   . VAL A 1 493 ? 125.962 112.936 110.878 1.00 48.90 ? 536 VAL A C   1 
ATOM 3768 O O   . VAL A 1 493 ? 124.786 113.248 111.120 1.00 56.71 ? 536 VAL A O   1 
ATOM 3769 C CB  . VAL A 1 493 ? 126.700 112.933 108.444 1.00 46.27 ? 536 VAL A CB  1 
ATOM 3770 C CG1 . VAL A 1 493 ? 127.630 111.733 108.443 1.00 45.78 ? 536 VAL A CG1 1 
ATOM 3771 C CG2 . VAL A 1 493 ? 125.284 112.517 108.124 1.00 51.09 ? 536 VAL A CG2 1 
ATOM 3772 N N   . ASP A 1 494 ? 126.575 111.955 111.542 1.00 54.65 ? 537 ASP A N   1 
ATOM 3773 C CA  . ASP A 1 494 ? 125.875 111.268 112.621 1.00 55.87 ? 537 ASP A CA  1 
ATOM 3774 C C   . ASP A 1 494 ? 125.498 112.245 113.725 1.00 53.52 ? 537 ASP A C   1 
ATOM 3775 O O   . ASP A 1 494 ? 124.416 112.140 114.316 1.00 53.92 ? 537 ASP A O   1 
ATOM 3776 C CB  . ASP A 1 494 ? 126.733 110.130 113.170 1.00 54.69 ? 537 ASP A CB  1 
ATOM 3777 C CG  . ASP A 1 494 ? 128.207 110.461 113.169 1.00 54.70 ? 537 ASP A CG  1 
ATOM 3778 O OD1 . ASP A 1 494 ? 128.543 111.657 113.282 1.00 52.45 ? 537 ASP A OD1 1 
ATOM 3779 O OD2 . ASP A 1 494 ? 129.029 109.529 113.054 1.00 57.36 ? 537 ASP A OD2 1 
ATOM 3780 N N   . GLN A 1 495 ? 126.368 113.221 113.995 1.00 51.76 ? 538 GLN A N   1 
ATOM 3781 C CA  . GLN A 1 495 ? 126.068 114.229 115.006 1.00 49.85 ? 538 GLN A CA  1 
ATOM 3782 C C   . GLN A 1 495 ? 124.809 115.007 114.651 1.00 57.10 ? 538 GLN A C   1 
ATOM 3783 O O   . GLN A 1 495 ? 123.912 115.165 115.487 1.00 59.98 ? 538 GLN A O   1 
ATOM 3784 C CB  . GLN A 1 495 ? 127.252 115.181 115.172 1.00 52.54 ? 538 GLN A CB  1 
ATOM 3785 C CG  . GLN A 1 495 ? 128.527 114.526 115.658 1.00 54.97 ? 538 GLN A CG  1 
ATOM 3786 C CD  . GLN A 1 495 ? 129.546 115.538 116.141 1.00 55.72 ? 538 GLN A CD  1 
ATOM 3787 O OE1 . GLN A 1 495 ? 129.205 116.680 116.447 1.00 51.69 ? 538 GLN A OE1 1 
ATOM 3788 N NE2 . GLN A 1 495 ? 130.805 115.124 116.212 1.00 59.18 ? 538 GLN A NE2 1 
ATOM 3789 N N   . THR A 1 496 ? 124.717 115.500 113.411 1.00 46.17 ? 539 THR A N   1 
ATOM 3790 C CA  . THR A 1 496 ? 123.563 116.319 113.054 1.00 46.86 ? 539 THR A CA  1 
ATOM 3791 C C   . THR A 1 496 ? 122.287 115.489 113.011 1.00 46.02 ? 539 THR A C   1 
ATOM 3792 O O   . THR A 1 496 ? 121.224 115.969 113.414 1.00 54.28 ? 539 THR A O   1 
ATOM 3793 C CB  . THR A 1 496 ? 123.786 117.050 111.724 1.00 46.84 ? 539 THR A CB  1 
ATOM 3794 O OG1 . THR A 1 496 ? 122.609 117.794 111.387 1.00 50.25 ? 539 THR A OG1 1 
ATOM 3795 C CG2 . THR A 1 496 ? 124.098 116.097 110.599 1.00 47.70 ? 539 THR A CG2 1 
ATOM 3796 N N   . ARG A 1 497 ? 122.368 114.236 112.558 1.00 35.45 ? 540 ARG A N   1 
ATOM 3797 C CA  . ARG A 1 497 ? 121.167 113.403 112.536 1.00 37.84 ? 540 ARG A CA  1 
ATOM 3798 C C   . ARG A 1 497 ? 120.674 113.098 113.950 1.00 45.07 ? 540 ARG A C   1 
ATOM 3799 O O   . ARG A 1 497 ? 119.476 113.236 114.249 1.00 54.14 ? 540 ARG A O   1 
ATOM 3800 C CB  . ARG A 1 497 ? 121.438 112.118 111.756 1.00 39.79 ? 540 ARG A CB  1 
ATOM 3801 C CG  . ARG A 1 497 ? 121.833 112.357 110.310 1.00 39.94 ? 540 ARG A CG  1 
ATOM 3802 C CD  . ARG A 1 497 ? 121.644 111.110 109.466 1.00 44.31 ? 540 ARG A CD  1 
ATOM 3803 N NE  . ARG A 1 497 ? 122.663 110.103 109.738 1.00 50.81 ? 540 ARG A NE  1 
ATOM 3804 C CZ  . ARG A 1 497 ? 123.463 109.581 108.819 1.00 47.59 ? 540 ARG A CZ  1 
ATOM 3805 N NH1 . ARG A 1 497 ? 123.391 109.948 107.551 1.00 44.45 ? 540 ARG A NH1 1 
ATOM 3806 N NH2 . ARG A 1 497 ? 124.357 108.666 109.182 1.00 48.50 ? 540 ARG A NH2 1 
ATOM 3807 N N   . ARG A 1 498 ? 121.584 112.696 114.842 1.00 41.67 ? 541 ARG A N   1 
ATOM 3808 C CA  . ARG A 1 498 ? 121.188 112.404 116.216 1.00 39.83 ? 541 ARG A CA  1 
ATOM 3809 C C   . ARG A 1 498 ? 120.668 113.652 116.917 1.00 49.94 ? 541 ARG A C   1 
ATOM 3810 O O   . ARG A 1 498 ? 119.698 113.585 117.683 1.00 52.54 ? 541 ARG A O   1 
ATOM 3811 C CB  . ARG A 1 498 ? 122.364 111.801 116.985 1.00 51.26 ? 541 ARG A CB  1 
ATOM 3812 C CG  . ARG A 1 498 ? 122.834 110.457 116.447 1.00 52.86 ? 541 ARG A CG  1 
ATOM 3813 C CD  . ARG A 1 498 ? 123.766 109.762 117.424 1.00 50.73 ? 541 ARG A CD  1 
ATOM 3814 N NE  . ARG A 1 498 ? 125.096 109.550 116.866 1.00 48.66 ? 541 ARG A NE  1 
ATOM 3815 C CZ  . ARG A 1 498 ? 126.202 110.115 117.331 1.00 46.37 ? 541 ARG A CZ  1 
ATOM 3816 N NH1 . ARG A 1 498 ? 126.174 110.944 118.361 1.00 48.39 ? 541 ARG A NH1 1 
ATOM 3817 N NH2 . ARG A 1 498 ? 127.365 109.839 116.750 1.00 46.88 ? 541 ARG A NH2 1 
ATOM 3818 N N   . ARG A 1 499 ? 121.295 114.805 116.667 1.00 50.17 ? 542 ARG A N   1 
ATOM 3819 C CA  . ARG A 1 499 ? 120.827 116.040 117.280 1.00 42.99 ? 542 ARG A CA  1 
ATOM 3820 C C   . ARG A 1 499 ? 119.471 116.459 116.731 1.00 49.37 ? 542 ARG A C   1 
ATOM 3821 O O   . ARG A 1 499 ? 118.652 117.007 117.473 1.00 53.95 ? 542 ARG A O   1 
ATOM 3822 C CB  . ARG A 1 499 ? 121.858 117.148 117.078 1.00 46.27 ? 542 ARG A CB  1 
ATOM 3823 C CG  . ARG A 1 499 ? 122.971 117.140 118.110 1.00 46.38 ? 542 ARG A CG  1 
ATOM 3824 C CD  . ARG A 1 499 ? 124.028 118.180 117.799 1.00 47.25 ? 542 ARG A CD  1 
ATOM 3825 N NE  . ARG A 1 499 ? 125.266 117.925 118.523 1.00 48.21 ? 542 ARG A NE  1 
ATOM 3826 C CZ  . ARG A 1 499 ? 126.376 118.637 118.384 1.00 51.54 ? 542 ARG A CZ  1 
ATOM 3827 N NH1 . ARG A 1 499 ? 126.439 119.662 117.550 1.00 53.10 ? 542 ARG A NH1 1 
ATOM 3828 N NH2 . ARG A 1 499 ? 127.448 118.313 119.099 1.00 52.55 ? 542 ARG A NH2 1 
ATOM 3829 N N   . VAL A 1 500 ? 119.213 116.212 115.445 1.00 47.60 ? 543 VAL A N   1 
ATOM 3830 C CA  . VAL A 1 500 ? 117.889 116.475 114.892 1.00 41.31 ? 543 VAL A CA  1 
ATOM 3831 C C   . VAL A 1 500 ? 116.848 115.623 115.600 1.00 32.91 ? 543 VAL A C   1 
ATOM 3832 O O   . VAL A 1 500 ? 115.773 116.111 115.972 1.00 43.16 ? 543 VAL A O   1 
ATOM 3833 C CB  . VAL A 1 500 ? 117.885 116.232 113.371 1.00 38.93 ? 543 VAL A CB  1 
ATOM 3834 C CG1 . VAL A 1 500 ? 116.498 115.839 112.894 1.00 37.97 ? 543 VAL A CG1 1 
ATOM 3835 C CG2 . VAL A 1 500 ? 118.371 117.469 112.637 1.00 47.28 ? 543 VAL A CG2 1 
ATOM 3836 N N   . LYS A 1 501 ? 117.154 114.341 115.811 1.00 32.40 ? 544 LYS A N   1 
ATOM 3837 C CA  . LYS A 1 501 ? 116.221 113.484 116.540 1.00 37.58 ? 544 LYS A CA  1 
ATOM 3838 C C   . LYS A 1 501 ? 115.992 113.993 117.961 1.00 44.56 ? 544 LYS A C   1 
ATOM 3839 O O   . LYS A 1 501 ? 114.850 114.043 118.438 1.00 47.85 ? 544 LYS A O   1 
ATOM 3840 C CB  . LYS A 1 501 ? 116.732 112.045 116.563 1.00 41.89 ? 544 LYS A CB  1 
ATOM 3841 C CG  . LYS A 1 501 ? 115.765 111.062 117.199 1.00 44.58 ? 544 LYS A CG  1 
ATOM 3842 C CD  . LYS A 1 501 ? 116.319 109.651 117.183 1.00 42.69 ? 544 LYS A CD  1 
ATOM 3843 C CE  . LYS A 1 501 ? 115.210 108.623 117.297 1.00 40.22 ? 544 LYS A CE  1 
ATOM 3844 N NZ  . LYS A 1 501 ? 115.743 107.235 117.299 1.00 42.84 ? 544 LYS A NZ  1 
ATOM 3845 N N   . ALA A 1 502 ? 117.066 114.393 118.646 1.00 43.68 ? 545 ALA A N   1 
ATOM 3846 C CA  . ALA A 1 502 ? 116.938 114.863 120.024 1.00 39.26 ? 545 ALA A CA  1 
ATOM 3847 C C   . ALA A 1 502 ? 116.121 116.148 120.106 1.00 42.18 ? 545 ALA A C   1 
ATOM 3848 O O   . ALA A 1 502 ? 115.292 116.311 121.011 1.00 46.17 ? 545 ALA A O   1 
ATOM 3849 C CB  . ALA A 1 502 ? 118.322 115.069 120.638 1.00 37.79 ? 545 ALA A CB  1 
ATOM 3850 N N   . TYR A 1 503 ? 116.340 117.077 119.174 1.00 45.14 ? 546 TYR A N   1 
ATOM 3851 C CA  . TYR A 1 503 ? 115.600 118.332 119.209 1.00 36.40 ? 546 TYR A CA  1 
ATOM 3852 C C   . TYR A 1 503 ? 114.152 118.145 118.783 1.00 41.05 ? 546 TYR A C   1 
ATOM 3853 O O   . TYR A 1 503 ? 113.277 118.878 119.251 1.00 41.48 ? 546 TYR A O   1 
ATOM 3854 C CB  . TYR A 1 503 ? 116.288 119.384 118.342 1.00 40.33 ? 546 TYR A CB  1 
ATOM 3855 C CG  . TYR A 1 503 ? 117.502 120.000 118.998 1.00 42.84 ? 546 TYR A CG  1 
ATOM 3856 C CD1 . TYR A 1 503 ? 117.386 120.708 120.184 1.00 43.02 ? 546 TYR A CD1 1 
ATOM 3857 C CD2 . TYR A 1 503 ? 118.760 119.886 118.425 1.00 43.04 ? 546 TYR A CD2 1 
ATOM 3858 C CE1 . TYR A 1 503 ? 118.490 121.275 120.787 1.00 42.56 ? 546 TYR A CE1 1 
ATOM 3859 C CE2 . TYR A 1 503 ? 119.869 120.450 119.020 1.00 42.93 ? 546 TYR A CE2 1 
ATOM 3860 C CZ  . TYR A 1 503 ? 119.729 121.144 120.200 1.00 44.92 ? 546 TYR A CZ  1 
ATOM 3861 O OH  . TYR A 1 503 ? 120.832 121.709 120.796 1.00 52.67 ? 546 TYR A OH  1 
ATOM 3862 N N   . LYS A 1 504 ? 113.872 117.179 117.904 1.00 41.42 ? 547 LYS A N   1 
ATOM 3863 C CA  . LYS A 1 504 ? 112.481 116.826 117.642 1.00 33.36 ? 547 LYS A CA  1 
ATOM 3864 C C   . LYS A 1 504 ? 111.824 116.260 118.891 1.00 35.36 ? 547 LYS A C   1 
ATOM 3865 O O   . LYS A 1 504 ? 110.655 116.546 119.171 1.00 40.96 ? 547 LYS A O   1 
ATOM 3866 C CB  . LYS A 1 504 ? 112.392 115.829 116.488 1.00 33.42 ? 547 LYS A CB  1 
ATOM 3867 C CG  . LYS A 1 504 ? 112.611 116.448 115.123 1.00 35.82 ? 547 LYS A CG  1 
ATOM 3868 C CD  . LYS A 1 504 ? 111.333 117.060 114.588 1.00 34.64 ? 547 LYS A CD  1 
ATOM 3869 C CE  . LYS A 1 504 ? 111.473 117.433 113.125 1.00 34.41 ? 547 LYS A CE  1 
ATOM 3870 N NZ  . LYS A 1 504 ? 110.295 118.196 112.638 1.00 39.38 ? 547 LYS A NZ  1 
ATOM 3871 N N   . ALA A 1 505 ? 112.561 115.448 119.653 1.00 32.58 ? 548 ALA A N   1 
ATOM 3872 C CA  . ALA A 1 505 ? 112.025 114.925 120.905 1.00 34.83 ? 548 ALA A CA  1 
ATOM 3873 C C   . ALA A 1 505 ? 111.726 116.045 121.893 1.00 38.92 ? 548 ALA A C   1 
ATOM 3874 O O   . ALA A 1 505 ? 110.679 116.041 122.551 1.00 41.83 ? 548 ALA A O   1 
ATOM 3875 C CB  . ALA A 1 505 ? 113.004 113.924 121.517 1.00 39.26 ? 548 ALA A CB  1 
ATOM 3876 N N   . LEU A 1 506 ? 112.636 117.014 122.011 1.00 50.23 ? 549 LEU A N   1 
ATOM 3877 C CA  . LEU A 1 506 ? 112.466 118.071 123.005 1.00 44.41 ? 549 LEU A CA  1 
ATOM 3878 C C   . LEU A 1 506 ? 111.392 119.071 122.591 1.00 44.72 ? 549 LEU A C   1 
ATOM 3879 O O   . LEU A 1 506 ? 110.615 119.540 123.432 1.00 44.47 ? 549 LEU A O   1 
ATOM 3880 C CB  . LEU A 1 506 ? 113.794 118.788 123.239 1.00 41.42 ? 549 LEU A CB  1 
ATOM 3881 C CG  . LEU A 1 506 ? 114.660 118.234 124.369 1.00 46.00 ? 549 LEU A CG  1 
ATOM 3882 C CD1 . LEU A 1 506 ? 115.914 119.071 124.535 1.00 43.67 ? 549 LEU A CD1 1 
ATOM 3883 C CD2 . LEU A 1 506 ? 113.872 118.172 125.665 1.00 46.82 ? 549 LEU A CD2 1 
ATOM 3884 N N   . MET A 1 507 ? 111.334 119.412 121.305 1.00 49.93 ? 550 MET A N   1 
ATOM 3885 C CA  . MET A 1 507 ? 110.447 120.440 120.773 1.00 39.83 ? 550 MET A CA  1 
ATOM 3886 C C   . MET A 1 507 ? 109.066 119.899 120.429 1.00 45.00 ? 550 MET A C   1 
ATOM 3887 O O   . MET A 1 507 ? 108.058 120.363 120.968 1.00 49.23 ? 550 MET A O   1 
ATOM 3888 C CB  . MET A 1 507 ? 111.077 121.053 119.522 1.00 40.70 ? 550 MET A CB  1 
ATOM 3889 C CG  . MET A 1 507 ? 112.251 121.959 119.782 1.00 45.71 ? 550 MET A CG  1 
ATOM 3890 S SD  . MET A 1 507 ? 112.211 122.742 121.395 1.00 56.13 ? 550 MET A SD  1 
ATOM 3891 C CE  . MET A 1 507 ? 111.164 124.139 121.000 1.00 46.21 ? 550 MET A CE  1 
ATOM 3892 N N   . GLY A 1 508 ? 109.012 118.930 119.533 1.00 45.17 ? 551 GLY A N   1 
ATOM 3893 C CA  . GLY A 1 508 ? 107.761 118.423 119.014 1.00 36.76 ? 551 GLY A CA  1 
ATOM 3894 C C   . GLY A 1 508 ? 107.953 117.864 117.627 1.00 41.61 ? 551 GLY A C   1 
ATOM 3895 O O   . GLY A 1 508 ? 108.956 118.111 116.956 1.00 49.08 ? 551 GLY A O   1 
ATOM 3896 N N   . ASP A 1 509 ? 106.963 117.086 117.192 1.00 31.40 ? 552 ASP A N   1 
ATOM 3897 C CA  . ASP A 1 509 ? 107.072 116.414 115.903 1.00 36.53 ? 552 ASP A CA  1 
ATOM 3898 C C   . ASP A 1 509 ? 107.088 117.409 114.750 1.00 38.42 ? 552 ASP A C   1 
ATOM 3899 O O   . ASP A 1 509 ? 107.837 117.234 113.783 1.00 46.22 ? 552 ASP A O   1 
ATOM 3900 C CB  . ASP A 1 509 ? 105.928 115.415 115.739 1.00 41.82 ? 552 ASP A CB  1 
ATOM 3901 C CG  . ASP A 1 509 ? 105.929 114.350 116.817 1.00 52.70 ? 552 ASP A CG  1 
ATOM 3902 O OD1 . ASP A 1 509 ? 104.832 113.919 117.231 1.00 55.54 ? 552 ASP A OD1 1 
ATOM 3903 O OD2 . ASP A 1 509 ? 107.027 113.946 117.253 1.00 51.39 ? 552 ASP A OD2 1 
ATOM 3904 N N   . TYR A 1 510 ? 106.275 118.459 114.832 1.00 32.84 ? 553 TYR A N   1 
ATOM 3905 C CA  . TYR A 1 510 ? 106.112 119.404 113.736 1.00 27.03 ? 553 TYR A CA  1 
ATOM 3906 C C   . TYR A 1 510 ? 107.043 120.605 113.823 1.00 35.26 ? 553 TYR A C   1 
ATOM 3907 O O   . TYR A 1 510 ? 107.000 121.462 112.935 1.00 42.00 ? 553 TYR A O   1 
ATOM 3908 C CB  . TYR A 1 510 ? 104.666 119.900 113.681 1.00 32.80 ? 553 TYR A CB  1 
ATOM 3909 C CG  . TYR A 1 510 ? 103.648 118.833 113.361 1.00 37.77 ? 553 TYR A CG  1 
ATOM 3910 C CD1 . TYR A 1 510 ? 103.388 118.463 112.051 1.00 35.37 ? 553 TYR A CD1 1 
ATOM 3911 C CD2 . TYR A 1 510 ? 102.935 118.204 114.371 1.00 40.12 ? 553 TYR A CD2 1 
ATOM 3912 C CE1 . TYR A 1 510 ? 102.454 117.492 111.756 1.00 39.49 ? 553 TYR A CE1 1 
ATOM 3913 C CE2 . TYR A 1 510 ? 102.001 117.234 114.087 1.00 33.83 ? 553 TYR A CE2 1 
ATOM 3914 C CZ  . TYR A 1 510 ? 101.763 116.881 112.778 1.00 38.53 ? 553 TYR A CZ  1 
ATOM 3915 O OH  . TYR A 1 510 ? 100.830 115.913 112.491 1.00 41.25 ? 553 TYR A OH  1 
ATOM 3916 N N   . PHE A 1 511 ? 107.869 120.696 114.855 1.00 36.80 ? 554 PHE A N   1 
ATOM 3917 C CA  . PHE A 1 511 ? 108.711 121.875 115.022 1.00 36.24 ? 554 PHE A CA  1 
ATOM 3918 C C   . PHE A 1 511 ? 109.783 121.917 113.939 1.00 31.26 ? 554 PHE A C   1 
ATOM 3919 O O   . PHE A 1 511 ? 110.440 120.902 113.684 1.00 45.20 ? 554 PHE A O   1 
ATOM 3920 C CB  . PHE A 1 511 ? 109.357 121.884 116.402 1.00 39.52 ? 554 PHE A CB  1 
ATOM 3921 C CG  . PHE A 1 511 ? 109.747 123.253 116.873 1.00 38.18 ? 554 PHE A CG  1 
ATOM 3922 C CD1 . PHE A 1 511 ? 108.815 124.087 117.462 1.00 37.23 ? 554 PHE A CD1 1 
ATOM 3923 C CD2 . PHE A 1 511 ? 111.042 123.710 116.717 1.00 35.68 ? 554 PHE A CD2 1 
ATOM 3924 C CE1 . PHE A 1 511 ? 109.170 125.347 117.892 1.00 43.37 ? 554 PHE A CE1 1 
ATOM 3925 C CE2 . PHE A 1 511 ? 111.401 124.968 117.144 1.00 38.26 ? 554 PHE A CE2 1 
ATOM 3926 C CZ  . PHE A 1 511 ? 110.465 125.788 117.732 1.00 39.56 ? 554 PHE A CZ  1 
ATOM 3927 N N   . PRO A 1 512 ? 109.987 123.058 113.282 1.00 22.91 ? 555 PRO A N   1 
ATOM 3928 C CA  . PRO A 1 512 ? 111.011 123.133 112.232 1.00 33.83 ? 555 PRO A CA  1 
ATOM 3929 C C   . PRO A 1 512 ? 112.410 123.002 112.815 1.00 38.24 ? 555 PRO A C   1 
ATOM 3930 O O   . PRO A 1 512 ? 112.794 123.743 113.722 1.00 44.34 ? 555 PRO A O   1 
ATOM 3931 C CB  . PRO A 1 512 ? 110.787 124.518 111.612 1.00 37.79 ? 555 PRO A CB  1 
ATOM 3932 C CG  . PRO A 1 512 ? 109.433 124.950 112.076 1.00 41.66 ? 555 PRO A CG  1 
ATOM 3933 C CD  . PRO A 1 512 ? 109.228 124.311 113.405 1.00 37.75 ? 555 PRO A CD  1 
ATOM 3934 N N   . VAL A 1 513 ? 113.169 122.048 112.284 1.00 36.64 ? 556 VAL A N   1 
ATOM 3935 C CA  . VAL A 1 513 ? 114.560 121.827 112.660 1.00 33.95 ? 556 VAL A CA  1 
ATOM 3936 C C   . VAL A 1 513 ? 115.369 121.698 111.380 1.00 29.20 ? 556 VAL A C   1 
ATOM 3937 O O   . VAL A 1 513 ? 114.955 120.997 110.451 1.00 42.51 ? 556 VAL A O   1 
ATOM 3938 C CB  . VAL A 1 513 ? 114.729 120.571 113.537 1.00 36.96 ? 556 VAL A CB  1 
ATOM 3939 C CG1 . VAL A 1 513 ? 116.190 120.361 113.893 1.00 41.31 ? 556 VAL A CG1 1 
ATOM 3940 C CG2 . VAL A 1 513 ? 113.886 120.677 114.796 1.00 41.90 ? 556 VAL A CG2 1 
ATOM 3941 N N   . THR A 1 514 ? 116.509 122.376 111.323 1.00 28.67 ? 557 THR A N   1 
ATOM 3942 C CA  . THR A 1 514 ? 117.382 122.313 110.162 1.00 37.00 ? 557 THR A CA  1 
ATOM 3943 C C   . THR A 1 514 ? 118.622 121.488 110.477 1.00 46.10 ? 557 THR A C   1 
ATOM 3944 O O   . THR A 1 514 ? 119.012 121.321 111.636 1.00 51.67 ? 557 THR A O   1 
ATOM 3945 C CB  . THR A 1 514 ? 117.785 123.716 109.690 1.00 43.42 ? 557 THR A CB  1 
ATOM 3946 O OG1 . THR A 1 514 ? 118.440 123.621 108.420 1.00 49.18 ? 557 THR A OG1 1 
ATOM 3947 C CG2 . THR A 1 514 ? 118.720 124.372 110.684 1.00 42.66 ? 557 THR A CG2 1 
ATOM 3948 N N   . ALA A 1 515 ? 119.236 120.961 109.417 1.00 50.04 ? 558 ALA A N   1 
ATOM 3949 C CA  . ALA A 1 515 ? 120.409 120.105 109.523 1.00 37.93 ? 558 ALA A CA  1 
ATOM 3950 C C   . ALA A 1 515 ? 121.706 120.863 109.275 1.00 38.08 ? 558 ALA A C   1 
ATOM 3951 O O   . ALA A 1 515 ? 122.748 120.237 109.051 1.00 51.75 ? 558 ALA A O   1 
ATOM 3952 C CB  . ALA A 1 515 ? 120.292 118.927 108.556 1.00 41.82 ? 558 ALA A CB  1 
ATOM 3953 N N   . ASP A 1 516 ? 121.654 122.195 109.292 1.00 33.79 ? 559 ASP A N   1 
ATOM 3954 C CA  . ASP A 1 516 ? 122.819 123.058 109.120 1.00 35.32 ? 559 ASP A CA  1 
ATOM 3955 C C   . ASP A 1 516 ? 123.473 122.872 107.757 1.00 35.47 ? 559 ASP A C   1 
ATOM 3956 O O   . ASP A 1 516 ? 122.970 122.127 106.910 1.00 50.58 ? 559 ASP A O   1 
ATOM 3957 C CB  . ASP A 1 516 ? 123.840 122.818 110.235 1.00 48.73 ? 559 ASP A CB  1 
ATOM 3958 C CG  . ASP A 1 516 ? 124.298 124.105 110.890 1.00 57.31 ? 559 ASP A CG  1 
ATOM 3959 O OD1 . ASP A 1 516 ? 124.880 124.038 111.993 1.00 57.00 ? 559 ASP A OD1 1 
ATOM 3960 O OD2 . ASP A 1 516 ? 124.076 125.184 110.302 1.00 57.13 ? 559 ASP A OD2 1 
ATOM 3961 N N   . HIS A 1 517 ? 124.596 123.557 107.538 1.00 39.46 ? 560 HIS A N   1 
ATOM 3962 C CA  . HIS A 1 517 ? 125.230 123.582 106.226 1.00 45.32 ? 560 HIS A CA  1 
ATOM 3963 C C   . HIS A 1 517 ? 126.752 123.524 106.304 1.00 51.21 ? 560 HIS A C   1 
ATOM 3964 O O   . HIS A 1 517 ? 127.426 124.020 105.394 1.00 50.94 ? 560 HIS A O   1 
ATOM 3965 C CB  . HIS A 1 517 ? 124.801 124.836 105.463 1.00 51.44 ? 560 HIS A CB  1 
ATOM 3966 C CG  . HIS A 1 517 ? 124.709 126.057 106.324 1.00 50.61 ? 560 HIS A CG  1 
ATOM 3967 N ND1 . HIS A 1 517 ? 125.788 126.872 106.580 1.00 42.90 ? 560 HIS A ND1 1 
ATOM 3968 C CD2 . HIS A 1 517 ? 123.666 126.594 106.999 1.00 50.56 ? 560 HIS A CD2 1 
ATOM 3969 C CE1 . HIS A 1 517 ? 125.415 127.862 107.369 1.00 47.89 ? 560 HIS A CE1 1 
ATOM 3970 N NE2 . HIS A 1 517 ? 124.131 127.716 107.639 1.00 53.17 ? 560 HIS A NE2 1 
ATOM 3971 N N   . ASN A 1 518 ? 127.313 122.949 107.371 1.00 49.04 ? 561 ASN A N   1 
ATOM 3972 C CA  . ASN A 1 518 ? 128.766 122.862 107.483 1.00 37.22 ? 561 ASN A CA  1 
ATOM 3973 C C   . ASN A 1 518 ? 129.354 121.998 106.375 1.00 45.29 ? 561 ASN A C   1 
ATOM 3974 O O   . ASN A 1 518 ? 130.389 122.342 105.793 1.00 52.50 ? 561 ASN A O   1 
ATOM 3975 C CB  . ASN A 1 518 ? 129.155 122.316 108.855 1.00 41.33 ? 561 ASN A CB  1 
ATOM 3976 C CG  . ASN A 1 518 ? 128.581 123.136 109.991 1.00 47.42 ? 561 ASN A CG  1 
ATOM 3977 O OD1 . ASN A 1 518 ? 127.365 123.248 110.139 1.00 48.71 ? 561 ASN A OD1 1 
ATOM 3978 N ND2 . ASN A 1 518 ? 129.457 123.713 110.803 1.00 52.35 ? 561 ASN A ND2 1 
ATOM 3979 N N   . ASN A 1 519 ? 128.710 120.875 106.070 1.00 47.67 ? 562 ASN A N   1 
ATOM 3980 C CA  . ASN A 1 519 ? 129.139 120.003 104.988 1.00 43.91 ? 562 ASN A CA  1 
ATOM 3981 C C   . ASN A 1 519 ? 127.913 119.509 104.233 1.00 47.66 ? 562 ASN A C   1 
ATOM 3982 O O   . ASN A 1 519 ? 126.803 119.466 104.767 1.00 45.54 ? 562 ASN A O   1 
ATOM 3983 C CB  . ASN A 1 519 ? 129.965 118.819 105.505 1.00 47.37 ? 562 ASN A CB  1 
ATOM 3984 C CG  . ASN A 1 519 ? 131.452 119.018 105.305 1.00 49.54 ? 562 ASN A CG  1 
ATOM 3985 O OD1 . ASN A 1 519 ? 131.947 118.992 104.179 1.00 47.46 ? 562 ASN A OD1 1 
ATOM 3986 N ND2 . ASN A 1 519 ? 132.174 119.222 106.400 1.00 50.78 ? 562 ASN A ND2 1 
ATOM 3987 N N   . ILE A 1 520 ? 128.131 119.135 102.974 1.00 44.97 ? 563 ILE A N   1 
ATOM 3988 C CA  . ILE A 1 520 ? 127.046 118.749 102.080 1.00 39.19 ? 563 ILE A CA  1 
ATOM 3989 C C   . ILE A 1 520 ? 126.529 117.365 102.446 1.00 43.85 ? 563 ILE A C   1 
ATOM 3990 O O   . ILE A 1 520 ? 127.165 116.350 102.142 1.00 44.94 ? 563 ILE A O   1 
ATOM 3991 C CB  . ILE A 1 520 ? 127.505 118.793 100.612 1.00 37.86 ? 563 ILE A CB  1 
ATOM 3992 C CG1 . ILE A 1 520 ? 128.309 120.066 100.347 1.00 36.93 ? 563 ILE A CG1 1 
ATOM 3993 C CG2 . ILE A 1 520 ? 126.310 118.691 99.680  1.00 43.95 ? 563 ILE A CG2 1 
ATOM 3994 C CD1 . ILE A 1 520 ? 128.430 120.426 98.885  1.00 41.17 ? 563 ILE A CD1 1 
ATOM 3995 N N   . TRP A 1 521 ? 125.371 117.316 103.099 1.00 39.59 ? 564 TRP A N   1 
ATOM 3996 C CA  . TRP A 1 521 ? 124.701 116.071 103.464 1.00 43.17 ? 564 TRP A CA  1 
ATOM 3997 C C   . TRP A 1 521 ? 123.217 116.151 103.129 1.00 46.58 ? 564 TRP A C   1 
ATOM 3998 O O   . TRP A 1 521 ? 122.349 115.915 103.972 1.00 52.09 ? 564 TRP A O   1 
ATOM 3999 C CB  . TRP A 1 521 ? 124.913 115.711 104.934 1.00 47.54 ? 564 TRP A CB  1 
ATOM 4000 C CG  . TRP A 1 521 ? 124.764 116.843 105.904 1.00 50.32 ? 564 TRP A CG  1 
ATOM 4001 C CD1 . TRP A 1 521 ? 123.640 117.572 106.150 1.00 46.70 ? 564 TRP A CD1 1 
ATOM 4002 C CD2 . TRP A 1 521 ? 125.769 117.344 106.793 1.00 46.98 ? 564 TRP A CD2 1 
ATOM 4003 N NE1 . TRP A 1 521 ? 123.887 118.511 107.120 1.00 47.75 ? 564 TRP A NE1 1 
ATOM 4004 C CE2 . TRP A 1 521 ? 125.188 118.390 107.532 1.00 43.60 ? 564 TRP A CE2 1 
ATOM 4005 C CE3 . TRP A 1 521 ? 127.108 117.017 107.026 1.00 47.31 ? 564 TRP A CE3 1 
ATOM 4006 C CZ2 . TRP A 1 521 ? 125.897 119.112 108.488 1.00 49.51 ? 564 TRP A CZ2 1 
ATOM 4007 C CZ3 . TRP A 1 521 ? 127.809 117.732 107.976 1.00 45.63 ? 564 TRP A CZ3 1 
ATOM 4008 C CH2 . TRP A 1 521 ? 127.204 118.768 108.694 1.00 50.84 ? 564 TRP A CH2 1 
ATOM 4009 N N   . TYR A 1 522 ? 122.913 116.518 101.878 1.00 45.76 ? 565 TYR A N   1 
ATOM 4010 C CA  . TYR A 1 522 ? 121.525 116.638 101.435 1.00 45.09 ? 565 TYR A CA  1 
ATOM 4011 C C   . TYR A 1 522 ? 120.718 115.385 101.754 1.00 40.70 ? 565 TYR A C   1 
ATOM 4012 O O   . TYR A 1 522 ? 119.537 115.473 102.113 1.00 48.55 ? 565 TYR A O   1 
ATOM 4013 C CB  . TYR A 1 522 ? 121.470 116.916 99.931  1.00 44.96 ? 565 TYR A CB  1 
ATOM 4014 C CG  . TYR A 1 522 ? 122.196 118.160 99.471  1.00 38.52 ? 565 TYR A CG  1 
ATOM 4015 C CD1 . TYR A 1 522 ? 122.341 119.257 100.304 1.00 36.95 ? 565 TYR A CD1 1 
ATOM 4016 C CD2 . TYR A 1 522 ? 122.721 118.239 98.189  1.00 42.36 ? 565 TYR A CD2 1 
ATOM 4017 C CE1 . TYR A 1 522 ? 122.998 120.393 99.880  1.00 41.02 ? 565 TYR A CE1 1 
ATOM 4018 C CE2 . TYR A 1 522 ? 123.378 119.370 97.756  1.00 40.97 ? 565 TYR A CE2 1 
ATOM 4019 C CZ  . TYR A 1 522 ? 123.513 120.444 98.604  1.00 46.18 ? 565 TYR A CZ  1 
ATOM 4020 O OH  . TYR A 1 522 ? 124.169 121.573 98.176  1.00 55.92 ? 565 TYR A OH  1 
ATOM 4021 N N   . LEU A 1 523 ? 121.335 114.209 101.610 1.00 44.90 ? 566 LEU A N   1 
ATOM 4022 C CA  . LEU A 1 523 ? 120.648 112.957 101.915 1.00 44.73 ? 566 LEU A CA  1 
ATOM 4023 C C   . LEU A 1 523 ? 120.131 112.945 103.347 1.00 44.66 ? 566 LEU A C   1 
ATOM 4024 O O   . LEU A 1 523 ? 118.963 112.627 103.597 1.00 53.90 ? 566 LEU A O   1 
ATOM 4025 C CB  . LEU A 1 523 ? 121.589 111.774 101.680 1.00 52.20 ? 566 LEU A CB  1 
ATOM 4026 C CG  . LEU A 1 523 ? 121.723 111.191 100.273 1.00 55.67 ? 566 LEU A CG  1 
ATOM 4027 C CD1 . LEU A 1 523 ? 120.360 110.780 99.750  1.00 53.58 ? 566 LEU A CD1 1 
ATOM 4028 C CD2 . LEU A 1 523 ? 122.399 112.169 99.321  1.00 55.40 ? 566 LEU A CD2 1 
ATOM 4029 N N   . SER A 1 524 ? 120.992 113.295 104.303 1.00 41.92 ? 567 SER A N   1 
ATOM 4030 C CA  . SER A 1 524 ? 120.585 113.290 105.703 1.00 41.96 ? 567 SER A CA  1 
ATOM 4031 C C   . SER A 1 524 ? 119.580 114.393 106.004 1.00 45.09 ? 567 SER A C   1 
ATOM 4032 O O   . SER A 1 524 ? 118.702 114.212 106.855 1.00 41.63 ? 567 SER A O   1 
ATOM 4033 C CB  . SER A 1 524 ? 121.813 113.426 106.597 1.00 44.74 ? 567 SER A CB  1 
ATOM 4034 O OG  . SER A 1 524 ? 122.820 112.518 106.192 1.00 50.31 ? 567 SER A OG  1 
ATOM 4035 N N   . ALA A 1 525 ? 119.694 115.537 105.329 1.00 41.32 ? 568 ALA A N   1 
ATOM 4036 C CA  . ALA A 1 525 ? 118.741 116.620 105.543 1.00 38.85 ? 568 ALA A CA  1 
ATOM 4037 C C   . ALA A 1 525 ? 117.342 116.219 105.092 1.00 43.77 ? 568 ALA A C   1 
ATOM 4038 O O   . ALA A 1 525 ? 116.361 116.437 105.811 1.00 48.72 ? 568 ALA A O   1 
ATOM 4039 C CB  . ALA A 1 525 ? 119.204 117.877 104.809 1.00 42.40 ? 568 ALA A CB  1 
ATOM 4040 N N   . VAL A 1 526 ? 117.231 115.633 103.899 1.00 47.45 ? 569 VAL A N   1 
ATOM 4041 C CA  . VAL A 1 526 ? 115.922 115.243 103.386 1.00 39.89 ? 569 VAL A CA  1 
ATOM 4042 C C   . VAL A 1 526 ? 115.370 114.048 104.155 1.00 36.42 ? 569 VAL A C   1 
ATOM 4043 O O   . VAL A 1 526 ? 114.187 114.016 104.510 1.00 38.86 ? 569 VAL A O   1 
ATOM 4044 C CB  . VAL A 1 526 ? 116.003 114.958 101.877 1.00 39.67 ? 569 VAL A CB  1 
ATOM 4045 C CG1 . VAL A 1 526 ? 114.647 114.533 101.345 1.00 43.40 ? 569 VAL A CG1 1 
ATOM 4046 C CG2 . VAL A 1 526 ? 116.503 116.184 101.137 1.00 44.82 ? 569 VAL A CG2 1 
ATOM 4047 N N   . GLY A 1 527 ? 116.213 113.050 104.426 1.00 38.85 ? 570 GLY A N   1 
ATOM 4048 C CA  . GLY A 1 527 ? 115.717 111.814 105.010 1.00 44.49 ? 570 GLY A CA  1 
ATOM 4049 C C   . GLY A 1 527 ? 115.189 111.980 106.422 1.00 47.49 ? 570 GLY A C   1 
ATOM 4050 O O   . GLY A 1 527 ? 114.198 111.351 106.800 1.00 52.69 ? 570 GLY A O   1 
ATOM 4051 N N   . THR A 1 528 ? 115.843 112.821 107.223 1.00 47.15 ? 571 THR A N   1 
ATOM 4052 C CA  . THR A 1 528 ? 115.444 113.007 108.611 1.00 45.33 ? 571 THR A CA  1 
ATOM 4053 C C   . THR A 1 528 ? 114.237 113.920 108.771 1.00 43.54 ? 571 THR A C   1 
ATOM 4054 O O   . THR A 1 528 ? 113.708 114.028 109.882 1.00 48.49 ? 571 THR A O   1 
ATOM 4055 C CB  . THR A 1 528 ? 116.614 113.565 109.425 1.00 45.76 ? 571 THR A CB  1 
ATOM 4056 O OG1 . THR A 1 528 ? 117.108 114.756 108.801 1.00 48.02 ? 571 THR A OG1 1 
ATOM 4057 C CG2 . THR A 1 528 ? 117.735 112.543 109.517 1.00 46.17 ? 571 THR A CG2 1 
ATOM 4058 N N   . GLY A 1 529 ? 113.786 114.567 107.702 1.00 46.62 ? 572 GLY A N   1 
ATOM 4059 C CA  . GLY A 1 529 ? 112.682 115.499 107.794 1.00 44.93 ? 572 GLY A CA  1 
ATOM 4060 C C   . GLY A 1 529 ? 113.070 116.912 108.155 1.00 46.28 ? 572 GLY A C   1 
ATOM 4061 O O   . GLY A 1 529 ? 112.217 117.670 108.631 1.00 53.27 ? 572 GLY A O   1 
ATOM 4062 N N   . SER A 1 530 ? 114.326 117.293 107.949 1.00 42.34 ? 573 SER A N   1 
ATOM 4063 C CA  . SER A 1 530 ? 114.804 118.616 108.307 1.00 38.15 ? 573 SER A CA  1 
ATOM 4064 C C   . SER A 1 530 ? 114.627 119.582 107.138 1.00 48.26 ? 573 SER A C   1 
ATOM 4065 O O   . SER A 1 530 ? 114.142 119.223 106.063 1.00 50.28 ? 573 SER A O   1 
ATOM 4066 C CB  . SER A 1 530 ? 116.265 118.548 108.747 1.00 40.20 ? 573 SER A CB  1 
ATOM 4067 O OG  . SER A 1 530 ? 116.431 117.637 109.819 1.00 47.63 ? 573 SER A OG  1 
ATOM 4068 N N   . VAL A 1 531 ? 115.027 120.832 107.354 1.00 47.78 ? 574 VAL A N   1 
ATOM 4069 C CA  . VAL A 1 531 ? 114.937 121.883 106.348 1.00 41.69 ? 574 VAL A CA  1 
ATOM 4070 C C   . VAL A 1 531 ? 116.291 122.016 105.669 1.00 45.32 ? 574 VAL A C   1 
ATOM 4071 O O   . VAL A 1 531 ? 117.320 122.163 106.340 1.00 50.79 ? 574 VAL A O   1 
ATOM 4072 C CB  . VAL A 1 531 ? 114.499 123.218 106.974 1.00 46.57 ? 574 VAL A CB  1 
ATOM 4073 C CG1 . VAL A 1 531 ? 114.377 124.289 105.905 1.00 46.39 ? 574 VAL A CG1 1 
ATOM 4074 C CG2 . VAL A 1 531 ? 113.186 123.049 107.719 1.00 45.73 ? 574 VAL A CG2 1 
ATOM 4075 N N   . LEU A 1 532 ? 116.293 121.965 104.341 1.00 48.78 ? 575 LEU A N   1 
ATOM 4076 C CA  . LEU A 1 532 ? 117.524 121.995 103.562 1.00 51.51 ? 575 LEU A CA  1 
ATOM 4077 C C   . LEU A 1 532 ? 117.947 123.440 103.324 1.00 52.37 ? 575 LEU A C   1 
ATOM 4078 O O   . LEU A 1 532 ? 117.183 124.230 102.759 1.00 58.86 ? 575 LEU A O   1 
ATOM 4079 C CB  . LEU A 1 532 ? 117.332 121.262 102.236 1.00 51.24 ? 575 LEU A CB  1 
ATOM 4080 C CG  . LEU A 1 532 ? 118.575 121.108 101.365 1.00 48.51 ? 575 LEU A CG  1 
ATOM 4081 C CD1 . LEU A 1 532 ? 119.727 120.577 102.197 1.00 50.51 ? 575 LEU A CD1 1 
ATOM 4082 C CD2 . LEU A 1 532 ? 118.290 120.192 100.191 1.00 48.91 ? 575 LEU A CD2 1 
ATOM 4083 N N   . ILE A 1 533 ? 119.163 123.783 103.754 1.00 45.90 ? 576 ILE A N   1 
ATOM 4084 C CA  . ILE A 1 533 ? 119.715 125.120 103.590 1.00 43.20 ? 576 ILE A CA  1 
ATOM 4085 C C   . ILE A 1 533 ? 121.148 125.008 103.083 1.00 40.86 ? 576 ILE A C   1 
ATOM 4086 O O   . ILE A 1 533 ? 121.814 123.984 103.250 1.00 48.71 ? 576 ILE A O   1 
ATOM 4087 C CB  . ILE A 1 533 ? 119.662 125.941 104.898 1.00 48.15 ? 576 ILE A CB  1 
ATOM 4088 C CG1 . ILE A 1 533 ? 120.563 125.322 105.965 1.00 48.07 ? 576 ILE A CG1 1 
ATOM 4089 C CG2 . ILE A 1 533 ? 118.233 126.050 105.411 1.00 47.38 ? 576 ILE A CG2 1 
ATOM 4090 C CD1 . ILE A 1 533 ? 120.394 125.948 107.330 1.00 48.66 ? 576 ILE A CD1 1 
ATOM 4091 N N   . GLU A 1 534 ? 121.619 126.085 102.455 1.00 40.95 ? 577 GLU A N   1 
ATOM 4092 C CA  . GLU A 1 534 ? 122.929 126.106 101.819 1.00 44.00 ? 577 GLU A CA  1 
ATOM 4093 C C   . GLU A 1 534 ? 123.600 127.449 102.079 1.00 49.14 ? 577 GLU A C   1 
ATOM 4094 O O   . GLU A 1 534 ? 122.936 128.458 102.325 1.00 53.09 ? 577 GLU A O   1 
ATOM 4095 C CB  . GLU A 1 534 ? 122.811 125.844 100.310 1.00 48.71 ? 577 GLU A CB  1 
ATOM 4096 C CG  . GLU A 1 534 ? 124.121 125.544 99.606  1.00 53.20 ? 577 GLU A CG  1 
ATOM 4097 C CD  . GLU A 1 534 ? 124.974 124.549 100.362 1.00 55.36 ? 577 GLU A CD  1 
ATOM 4098 O OE1 . GLU A 1 534 ? 124.541 123.388 100.513 1.00 59.05 ? 577 GLU A OE1 1 
ATOM 4099 O OE2 . GLU A 1 534 ? 126.076 124.928 100.807 1.00 57.31 ? 577 GLU A OE2 1 
ATOM 4100 N N   . LYS A 1 535 ? 124.937 127.452 102.024 1.00 49.65 ? 578 LYS A N   1 
ATOM 4101 C CA  . LYS A 1 535 ? 125.720 128.664 102.225 1.00 46.00 ? 578 LYS A CA  1 
ATOM 4102 C C   . LYS A 1 535 ? 126.546 129.084 101.017 1.00 51.05 ? 578 LYS A C   1 
ATOM 4103 O O   . LYS A 1 535 ? 126.895 130.265 100.918 1.00 57.39 ? 578 LYS A O   1 
ATOM 4104 C CB  . LYS A 1 535 ? 126.687 128.509 103.415 1.00 48.55 ? 578 LYS A CB  1 
ATOM 4105 C CG  . LYS A 1 535 ? 128.076 128.010 103.002 1.00 53.70 ? 578 LYS A CG  1 
ATOM 4106 C CD  . LYS A 1 535 ? 129.103 127.980 104.131 1.00 56.92 ? 578 LYS A CD  1 
ATOM 4107 C CE  . LYS A 1 535 ? 128.564 127.363 105.397 1.00 54.10 ? 578 LYS A CE  1 
ATOM 4108 N NZ  . LYS A 1 535 ? 129.635 126.751 106.231 1.00 53.03 ? 578 LYS A NZ  1 
ATOM 4109 N N   . ARG A 1 536 ? 126.866 128.170 100.106 1.00 47.30 ? 579 ARG A N   1 
ATOM 4110 C CA  . ARG A 1 536 ? 127.922 128.399 99.134  1.00 46.37 ? 579 ARG A CA  1 
ATOM 4111 C C   . ARG A 1 536 ? 127.384 129.015 97.846  1.00 46.58 ? 579 ARG A C   1 
ATOM 4112 O O   . ARG A 1 536 ? 126.181 129.036 97.581  1.00 54.79 ? 579 ARG A O   1 
ATOM 4113 C CB  . ARG A 1 536 ? 128.650 127.091 98.822  1.00 46.67 ? 579 ARG A CB  1 
ATOM 4114 C CG  . ARG A 1 536 ? 129.166 126.357 100.048 1.00 46.76 ? 579 ARG A CG  1 
ATOM 4115 C CD  . ARG A 1 536 ? 129.191 124.854 99.836  1.00 45.35 ? 579 ARG A CD  1 
ATOM 4116 N NE  . ARG A 1 536 ? 129.811 124.160 100.958 1.00 47.28 ? 579 ARG A NE  1 
ATOM 4117 C CZ  . ARG A 1 536 ? 129.178 123.826 102.074 1.00 44.01 ? 579 ARG A CZ  1 
ATOM 4118 N NH1 . ARG A 1 536 ? 127.897 124.100 102.250 1.00 49.34 ? 579 ARG A NH1 1 
ATOM 4119 N NH2 . ARG A 1 536 ? 129.848 123.200 103.037 1.00 44.90 ? 579 ARG A NH2 1 
ATOM 4120 N N   . ASP A 1 537 ? 128.313 129.521 97.038  1.00 46.96 ? 580 ASP A N   1 
ATOM 4121 C CA  . ASP A 1 537 ? 128.027 130.004 95.689  1.00 51.99 ? 580 ASP A CA  1 
ATOM 4122 C C   . ASP A 1 537 ? 128.413 128.872 94.745  1.00 54.61 ? 580 ASP A C   1 
ATOM 4123 O O   . ASP A 1 537 ? 129.571 128.732 94.349  1.00 58.53 ? 580 ASP A O   1 
ATOM 4124 C CB  . ASP A 1 537 ? 128.790 131.290 95.395  1.00 58.53 ? 580 ASP A CB  1 
ATOM 4125 C CG  . ASP A 1 537 ? 128.736 131.679 93.933  1.00 58.61 ? 580 ASP A CG  1 
ATOM 4126 O OD1 . ASP A 1 537 ? 127.690 131.450 93.291  1.00 60.16 ? 580 ASP A OD1 1 
ATOM 4127 O OD2 . ASP A 1 537 ? 129.741 132.219 93.425  1.00 57.16 ? 580 ASP A OD2 1 
ATOM 4128 N N   . LEU A 1 538 ? 127.429 128.055 94.390  1.00 52.45 ? 581 LEU A N   1 
ATOM 4129 C CA  . LEU A 1 538 ? 127.680 126.795 93.710  1.00 51.04 ? 581 LEU A CA  1 
ATOM 4130 C C   . LEU A 1 538 ? 127.632 126.980 92.200  1.00 55.07 ? 581 LEU A C   1 
ATOM 4131 O O   . LEU A 1 538 ? 126.773 127.694 91.676  1.00 58.02 ? 581 LEU A O   1 
ATOM 4132 C CB  . LEU A 1 538 ? 126.654 125.751 94.149  1.00 55.96 ? 581 LEU A CB  1 
ATOM 4133 C CG  . LEU A 1 538 ? 127.043 124.998 95.423  1.00 57.79 ? 581 LEU A CG  1 
ATOM 4134 C CD1 . LEU A 1 538 ? 125.827 124.352 96.072  1.00 55.40 ? 581 LEU A CD1 1 
ATOM 4135 C CD2 . LEU A 1 538 ? 128.134 123.983 95.157  1.00 57.75 ? 581 LEU A CD2 1 
ATOM 4136 N N   . SER A 1 539 ? 128.561 126.328 91.502  1.00 56.27 ? 582 SER A N   1 
ATOM 4137 C CA  . SER A 1 539 ? 128.643 126.434 90.051  1.00 56.74 ? 582 SER A CA  1 
ATOM 4138 C C   . SER A 1 539 ? 129.185 125.133 89.481  1.00 56.69 ? 582 SER A C   1 
ATOM 4139 O O   . SER A 1 539 ? 130.263 124.682 89.878  1.00 58.48 ? 582 SER A O   1 
ATOM 4140 C CB  . SER A 1 539 ? 129.534 127.608 89.633  1.00 58.68 ? 582 SER A CB  1 
ATOM 4141 O OG  . SER A 1 539 ? 130.904 127.298 89.813  1.00 62.08 ? 582 SER A OG  1 
ATOM 4142 N N   . GLY A 1 540 ? 128.438 124.538 88.553  1.00 60.04 ? 583 GLY A N   1 
ATOM 4143 C CA  . GLY A 1 540 ? 128.874 123.327 87.886  1.00 58.02 ? 583 GLY A CA  1 
ATOM 4144 C C   . GLY A 1 540 ? 128.100 122.082 88.270  1.00 56.77 ? 583 GLY A C   1 
ATOM 4145 O O   . GLY A 1 540 ? 126.875 122.120 88.431  1.00 63.74 ? 583 GLY A O   1 
ATOM 4146 N N   . THR A 1 541 ? 128.815 120.963 88.408  1.00 52.49 ? 584 THR A N   1 
ATOM 4147 C CA  . THR A 1 541 ? 128.166 119.702 88.752  1.00 55.98 ? 584 THR A CA  1 
ATOM 4148 C C   . THR A 1 541 ? 127.520 119.771 90.129  1.00 59.51 ? 584 THR A C   1 
ATOM 4149 O O   . THR A 1 541 ? 126.402 119.280 90.327  1.00 66.69 ? 584 THR A O   1 
ATOM 4150 C CB  . THR A 1 541 ? 129.181 118.560 88.690  1.00 61.32 ? 584 THR A CB  1 
ATOM 4151 O OG1 . THR A 1 541 ? 129.653 118.413 87.345  1.00 62.50 ? 584 THR A OG1 1 
ATOM 4152 C CG2 . THR A 1 541 ? 128.548 117.252 89.140  1.00 60.11 ? 584 THR A CG2 1 
ATOM 4153 N N   . ALA A 1 542 ? 128.207 120.380 91.096  1.00 49.67 ? 585 ALA A N   1 
ATOM 4154 C CA  . ALA A 1 542 ? 127.624 120.532 92.424  1.00 52.99 ? 585 ALA A CA  1 
ATOM 4155 C C   . ALA A 1 542 ? 126.427 121.474 92.393  1.00 54.37 ? 585 ALA A C   1 
ATOM 4156 O O   . ALA A 1 542 ? 125.479 121.307 93.165  1.00 54.89 ? 585 ALA A O   1 
ATOM 4157 C CB  . ALA A 1 542 ? 128.685 121.021 93.407  1.00 57.63 ? 585 ALA A CB  1 
ATOM 4158 N N   . LYS A 1 543 ? 126.453 122.463 91.500  1.00 56.72 ? 586 LYS A N   1 
ATOM 4159 C CA  . LYS A 1 543 ? 125.299 123.337 91.301  1.00 57.61 ? 586 LYS A CA  1 
ATOM 4160 C C   . LYS A 1 543 ? 124.098 122.553 90.777  1.00 55.77 ? 586 LYS A C   1 
ATOM 4161 O O   . LYS A 1 543 ? 122.965 122.732 91.251  1.00 54.31 ? 586 LYS A O   1 
ATOM 4162 C CB  . LYS A 1 543 ? 125.703 124.457 90.342  1.00 57.11 ? 586 LYS A CB  1 
ATOM 4163 C CG  . LYS A 1 543 ? 124.644 125.028 89.423  1.00 55.06 ? 586 LYS A CG  1 
ATOM 4164 C CD  . LYS A 1 543 ? 123.618 125.853 90.160  1.00 57.08 ? 586 LYS A CD  1 
ATOM 4165 C CE  . LYS A 1 543 ? 122.863 126.723 89.175  1.00 58.47 ? 586 LYS A CE  1 
ATOM 4166 N NZ  . LYS A 1 543 ? 123.783 127.420 88.239  1.00 58.66 ? 586 LYS A NZ  1 
ATOM 4167 N N   . GLU A 1 544 ? 124.333 121.669 89.803  1.00 52.03 ? 587 GLU A N   1 
ATOM 4168 C CA  . GLU A 1 544 ? 123.263 120.815 89.298  1.00 46.16 ? 587 GLU A CA  1 
ATOM 4169 C C   . GLU A 1 544 ? 122.733 119.897 90.390  1.00 45.76 ? 587 GLU A C   1 
ATOM 4170 O O   . GLU A 1 544 ? 121.521 119.676 90.493  1.00 58.35 ? 587 GLU A O   1 
ATOM 4171 C CB  . GLU A 1 544 ? 123.762 119.998 88.108  1.00 53.96 ? 587 GLU A CB  1 
ATOM 4172 C CG  . GLU A 1 544 ? 124.094 120.823 86.880  1.00 58.40 ? 587 GLU A CG  1 
ATOM 4173 C CD  . GLU A 1 544 ? 124.084 120.000 85.607  1.00 62.81 ? 587 GLU A CD  1 
ATOM 4174 O OE1 . GLU A 1 544 ? 125.146 119.447 85.249  1.00 60.41 ? 587 GLU A OE1 1 
ATOM 4175 O OE2 . GLU A 1 544 ? 123.016 119.903 84.966  1.00 61.31 ? 587 GLU A OE2 1 
ATOM 4176 N N   . GLU A 1 545 ? 123.630 119.347 91.210  1.00 41.91 ? 588 GLU A N   1 
ATOM 4177 C CA  . GLU A 1 545 ? 123.202 118.509 92.327  1.00 49.68 ? 588 GLU A CA  1 
ATOM 4178 C C   . GLU A 1 545 ? 122.361 119.302 93.321  1.00 56.37 ? 588 GLU A C   1 
ATOM 4179 O O   . GLU A 1 545 ? 121.363 118.795 93.851  1.00 61.91 ? 588 GLU A O   1 
ATOM 4180 C CB  . GLU A 1 545 ? 124.422 117.902 93.021  1.00 54.59 ? 588 GLU A CB  1 
ATOM 4181 C CG  . GLU A 1 545 ? 124.093 117.028 94.218  1.00 54.52 ? 588 GLU A CG  1 
ATOM 4182 C CD  . GLU A 1 545 ? 124.078 115.554 93.877  1.00 57.58 ? 588 GLU A CD  1 
ATOM 4183 O OE1 . GLU A 1 545 ? 124.263 115.215 92.689  1.00 58.93 ? 588 GLU A OE1 1 
ATOM 4184 O OE2 . GLU A 1 545 ? 123.880 114.732 94.796  1.00 54.72 ? 588 GLU A OE2 1 
ATOM 4185 N N   . TYR A 1 546 ? 122.757 120.548 93.589  1.00 55.61 ? 589 TYR A N   1 
ATOM 4186 C CA  . TYR A 1 546 ? 122.006 121.399 94.504  1.00 52.88 ? 589 TYR A CA  1 
ATOM 4187 C C   . TYR A 1 546 ? 120.594 121.633 93.986  1.00 52.11 ? 589 TYR A C   1 
ATOM 4188 O O   . TYR A 1 546 ? 119.620 121.514 94.736  1.00 54.82 ? 589 TYR A O   1 
ATOM 4189 C CB  . TYR A 1 546 ? 122.744 122.726 94.692  1.00 55.39 ? 589 TYR A CB  1 
ATOM 4190 C CG  . TYR A 1 546 ? 122.059 123.719 95.607  1.00 51.69 ? 589 TYR A CG  1 
ATOM 4191 C CD1 . TYR A 1 546 ? 121.283 123.294 96.676  1.00 53.29 ? 589 TYR A CD1 1 
ATOM 4192 C CD2 . TYR A 1 546 ? 122.185 125.083 95.393  1.00 50.76 ? 589 TYR A CD2 1 
ATOM 4193 C CE1 . TYR A 1 546 ? 120.661 124.200 97.511  1.00 52.20 ? 589 TYR A CE1 1 
ATOM 4194 C CE2 . TYR A 1 546 ? 121.563 125.994 96.219  1.00 47.95 ? 589 TYR A CE2 1 
ATOM 4195 C CZ  . TYR A 1 546 ? 120.802 125.547 97.275  1.00 49.95 ? 589 TYR A CZ  1 
ATOM 4196 O OH  . TYR A 1 546 ? 120.181 126.452 98.103  1.00 58.26 ? 589 TYR A OH  1 
ATOM 4197 N N   . GLU A 1 547 ? 120.464 121.958 92.697  1.00 53.50 ? 590 GLU A N   1 
ATOM 4198 C CA  . GLU A 1 547 ? 119.127 122.139 92.130  1.00 47.61 ? 590 GLU A CA  1 
ATOM 4199 C C   . GLU A 1 547 ? 118.323 120.845 92.138  1.00 44.20 ? 590 GLU A C   1 
ATOM 4200 O O   . GLU A 1 547 ? 117.116 120.864 92.406  1.00 51.10 ? 590 GLU A O   1 
ATOM 4201 C CB  . GLU A 1 547 ? 119.205 122.719 90.721  1.00 47.06 ? 590 GLU A CB  1 
ATOM 4202 C CG  . GLU A 1 547 ? 118.908 124.203 90.686  1.00 50.90 ? 590 GLU A CG  1 
ATOM 4203 C CD  . GLU A 1 547 ? 119.847 124.989 89.811  1.00 57.14 ? 590 GLU A CD  1 
ATOM 4204 O OE1 . GLU A 1 547 ? 120.095 126.164 90.146  1.00 55.34 ? 590 GLU A OE1 1 
ATOM 4205 O OE2 . GLU A 1 547 ? 120.342 124.437 88.806  1.00 64.60 ? 590 GLU A OE2 1 
ATOM 4206 N N   . LYS A 1 548 ? 118.963 119.713 91.842  1.00 41.36 ? 591 LYS A N   1 
ATOM 4207 C CA  . LYS A 1 548 ? 118.241 118.445 91.854  1.00 42.35 ? 591 LYS A CA  1 
ATOM 4208 C C   . LYS A 1 548 ? 117.682 118.144 93.238  1.00 40.99 ? 591 LYS A C   1 
ATOM 4209 O O   . LYS A 1 548 ? 116.512 117.762 93.380  1.00 51.74 ? 591 LYS A O   1 
ATOM 4210 C CB  . LYS A 1 548 ? 119.159 117.315 91.389  1.00 50.40 ? 591 LYS A CB  1 
ATOM 4211 C CG  . LYS A 1 548 ? 118.804 115.948 91.952  1.00 49.96 ? 591 LYS A CG  1 
ATOM 4212 C CD  . LYS A 1 548 ? 119.954 114.972 91.789  1.00 46.91 ? 591 LYS A CD  1 
ATOM 4213 C CE  . LYS A 1 548 ? 119.459 113.538 91.736  1.00 51.74 ? 591 LYS A CE  1 
ATOM 4214 N NZ  . LYS A 1 548 ? 119.062 113.022 93.073  1.00 54.52 ? 591 LYS A NZ  1 
ATOM 4215 N N   . TRP A 1 549 ? 118.494 118.334 94.277  1.00 34.74 ? 592 TRP A N   1 
ATOM 4216 C CA  . TRP A 1 549 ? 118.016 118.024 95.617  1.00 45.67 ? 592 TRP A CA  1 
ATOM 4217 C C   . TRP A 1 549 ? 117.034 119.069 96.128  1.00 53.90 ? 592 TRP A C   1 
ATOM 4218 O O   . TRP A 1 549 ? 116.132 118.733 96.904  1.00 54.92 ? 592 TRP A O   1 
ATOM 4219 C CB  . TRP A 1 549 ? 119.195 117.854 96.572  1.00 50.61 ? 592 TRP A CB  1 
ATOM 4220 C CG  . TRP A 1 549 ? 119.722 116.459 96.532  1.00 46.32 ? 592 TRP A CG  1 
ATOM 4221 C CD1 . TRP A 1 549 ? 120.906 116.042 96.003  1.00 47.66 ? 592 TRP A CD1 1 
ATOM 4222 C CD2 . TRP A 1 549 ? 119.052 115.283 96.993  1.00 46.02 ? 592 TRP A CD2 1 
ATOM 4223 N NE1 . TRP A 1 549 ? 121.027 114.681 96.130  1.00 50.55 ? 592 TRP A NE1 1 
ATOM 4224 C CE2 . TRP A 1 549 ? 119.899 114.191 96.734  1.00 46.13 ? 592 TRP A CE2 1 
ATOM 4225 C CE3 . TRP A 1 549 ? 117.821 115.050 97.612  1.00 52.15 ? 592 TRP A CE3 1 
ATOM 4226 C CZ2 . TRP A 1 549 ? 119.556 112.887 97.071  1.00 50.53 ? 592 TRP A CZ2 1 
ATOM 4227 C CZ3 . TRP A 1 549 ? 117.483 113.756 97.946  1.00 56.26 ? 592 TRP A CZ3 1 
ATOM 4228 C CH2 . TRP A 1 549 ? 118.345 112.690 97.674  1.00 51.54 ? 592 TRP A CH2 1 
ATOM 4229 N N   . LEU A 1 550 ? 117.164 120.324 95.688  1.00 53.83 ? 593 LEU A N   1 
ATOM 4230 C CA  . LEU A 1 550 ? 116.132 121.311 95.982  1.00 43.93 ? 593 LEU A CA  1 
ATOM 4231 C C   . LEU A 1 550 ? 114.802 120.903 95.369  1.00 40.60 ? 593 LEU A C   1 
ATOM 4232 O O   . LEU A 1 550 ? 113.752 121.027 96.006  1.00 47.33 ? 593 LEU A O   1 
ATOM 4233 C CB  . LEU A 1 550 ? 116.552 122.686 95.467  1.00 38.57 ? 593 LEU A CB  1 
ATOM 4234 C CG  . LEU A 1 550 ? 117.444 123.538 96.369  1.00 41.43 ? 593 LEU A CG  1 
ATOM 4235 C CD1 . LEU A 1 550 ? 117.330 125.004 95.993  1.00 46.85 ? 593 LEU A CD1 1 
ATOM 4236 C CD2 . LEU A 1 550 ? 117.104 123.329 97.834  1.00 45.27 ? 593 LEU A CD2 1 
ATOM 4237 N N   . GLY A 1 551 ? 114.828 120.414 94.128  1.00 42.99 ? 594 GLY A N   1 
ATOM 4238 C CA  . GLY A 1 551 ? 113.606 119.938 93.504  1.00 42.29 ? 594 GLY A CA  1 
ATOM 4239 C C   . GLY A 1 551 ? 113.010 118.747 94.227  1.00 37.84 ? 594 GLY A C   1 
ATOM 4240 O O   . GLY A 1 551 ? 111.791 118.652 94.388  1.00 49.01 ? 594 GLY A O   1 
ATOM 4241 N N   . ILE A 1 552 ? 113.860 117.819 94.671  1.00 41.98 ? 595 ILE A N   1 
ATOM 4242 C CA  . ILE A 1 552 ? 113.365 116.666 95.422  1.00 47.00 ? 595 ILE A CA  1 
ATOM 4243 C C   . ILE A 1 552 ? 112.707 117.122 96.721  1.00 46.25 ? 595 ILE A C   1 
ATOM 4244 O O   . ILE A 1 552 ? 111.606 116.679 97.072  1.00 51.08 ? 595 ILE A O   1 
ATOM 4245 C CB  . ILE A 1 552 ? 114.504 115.664 95.686  1.00 48.50 ? 595 ILE A CB  1 
ATOM 4246 C CG1 . ILE A 1 552 ? 114.731 114.778 94.459  1.00 54.18 ? 595 ILE A CG1 1 
ATOM 4247 C CG2 . ILE A 1 552 ? 114.198 114.813 96.911  1.00 48.00 ? 595 ILE A CG2 1 
ATOM 4248 C CD1 . ILE A 1 552 ? 113.850 113.548 94.412  1.00 52.24 ? 595 ILE A CD1 1 
ATOM 4249 N N   . ALA A 1 553 ? 113.364 118.031 97.444  1.00 46.03 ? 596 ALA A N   1 
ATOM 4250 C CA  . ALA A 1 553 ? 112.796 118.535 98.690  1.00 49.03 ? 596 ALA A CA  1 
ATOM 4251 C C   . ALA A 1 553 ? 111.492 119.280 98.440  1.00 52.52 ? 596 ALA A C   1 
ATOM 4252 O O   . ALA A 1 553 ? 110.558 119.201 99.246  1.00 53.26 ? 596 ALA A O   1 
ATOM 4253 C CB  . ALA A 1 553 ? 113.804 119.437 99.401  1.00 50.73 ? 596 ALA A CB  1 
ATOM 4254 N N   . ASP A 1 554 ? 111.413 120.014 97.329  1.00 55.44 ? 597 ASP A N   1 
ATOM 4255 C CA  . ASP A 1 554 ? 110.193 120.743 97.006  1.00 47.11 ? 597 ASP A CA  1 
ATOM 4256 C C   . ASP A 1 554 ? 109.056 119.792 96.653  1.00 48.35 ? 597 ASP A C   1 
ATOM 4257 O O   . ASP A 1 554 ? 107.894 120.058 96.978  1.00 52.11 ? 597 ASP A O   1 
ATOM 4258 C CB  . ASP A 1 554 ? 110.455 121.719 95.860  1.00 50.38 ? 597 ASP A CB  1 
ATOM 4259 C CG  . ASP A 1 554 ? 109.698 123.021 96.020  1.00 59.53 ? 597 ASP A CG  1 
ATOM 4260 O OD1 . ASP A 1 554 ? 109.581 123.503 97.166  1.00 59.27 ? 597 ASP A OD1 1 
ATOM 4261 O OD2 . ASP A 1 554 ? 109.221 123.563 95.001  1.00 59.03 ? 597 ASP A OD2 1 
ATOM 4262 N N   . THR A 1 555 ? 109.367 118.683 95.984  1.00 47.10 ? 598 THR A N   1 
ATOM 4263 C CA  . THR A 1 555 ? 108.331 117.741 95.586  1.00 44.76 ? 598 THR A CA  1 
ATOM 4264 C C   . THR A 1 555 ? 107.950 116.762 96.688  1.00 43.15 ? 598 THR A C   1 
ATOM 4265 O O   . THR A 1 555 ? 106.916 116.097 96.563  1.00 53.52 ? 598 THR A O   1 
ATOM 4266 C CB  . THR A 1 555 ? 108.765 116.962 94.340  1.00 46.96 ? 598 THR A CB  1 
ATOM 4267 O OG1 . THR A 1 555 ? 107.612 116.402 93.702  1.00 49.52 ? 598 THR A OG1 1 
ATOM 4268 C CG2 . THR A 1 555 ? 109.717 115.838 94.708  1.00 44.45 ? 598 THR A CG2 1 
ATOM 4269 N N   . VAL A 1 556 ? 108.738 116.649 97.753  1.00 44.42 ? 599 VAL A N   1 
ATOM 4270 C CA  . VAL A 1 556 ? 108.428 115.726 98.838  1.00 46.82 ? 599 VAL A CA  1 
ATOM 4271 C C   . VAL A 1 556 ? 107.882 116.449 100.065 1.00 50.52 ? 599 VAL A C   1 
ATOM 4272 O O   . VAL A 1 556 ? 106.897 116.002 100.655 1.00 51.42 ? 599 VAL A O   1 
ATOM 4273 C CB  . VAL A 1 556 ? 109.666 114.876 99.196  1.00 53.09 ? 599 VAL A CB  1 
ATOM 4274 C CG1 . VAL A 1 556 ? 109.344 113.940 100.339 1.00 50.66 ? 599 VAL A CG1 1 
ATOM 4275 C CG2 . VAL A 1 556 ? 110.124 114.078 97.987  1.00 54.61 ? 599 VAL A CG2 1 
ATOM 4276 N N   . GLN A 1 557 ? 108.497 117.569 100.457 1.00 58.18 ? 600 GLN A N   1 
ATOM 4277 C CA  . GLN A 1 557 ? 108.078 118.350 101.627 1.00 52.39 ? 600 GLN A CA  1 
ATOM 4278 C C   . GLN A 1 557 ? 108.036 117.496 102.897 1.00 52.23 ? 600 GLN A C   1 
ATOM 4279 O O   . GLN A 1 557 ? 106.987 117.300 103.509 1.00 55.49 ? 600 GLN A O   1 
ATOM 4280 C CB  . GLN A 1 557 ? 106.723 119.032 101.393 1.00 54.46 ? 600 GLN A CB  1 
ATOM 4281 C CG  . GLN A 1 557 ? 106.449 119.478 99.973  1.00 57.00 ? 600 GLN A CG  1 
ATOM 4282 C CD  . GLN A 1 557 ? 106.977 120.871 99.710  1.00 58.45 ? 600 GLN A CD  1 
ATOM 4283 O OE1 . GLN A 1 557 ? 108.167 121.057 99.460  1.00 58.41 ? 600 GLN A OE1 1 
ATOM 4284 N NE2 . GLN A 1 557 ? 106.089 121.852 99.724  1.00 55.82 ? 600 GLN A NE2 1 
ATOM 4285 N N   . LEU A 1 558 ? 109.203 116.997 103.295 1.00 41.42 ? 601 LEU A N   1 
ATOM 4286 C CA  . LEU A 1 558 ? 109.307 116.271 104.554 1.00 40.06 ? 601 LEU A CA  1 
ATOM 4287 C C   . LEU A 1 558 ? 109.551 117.182 105.749 1.00 45.87 ? 601 LEU A C   1 
ATOM 4288 O O   . LEU A 1 558 ? 109.491 116.709 106.888 1.00 52.48 ? 601 LEU A O   1 
ATOM 4289 C CB  . LEU A 1 558 ? 110.419 115.220 104.480 1.00 43.56 ? 601 LEU A CB  1 
ATOM 4290 C CG  . LEU A 1 558 ? 110.047 113.889 103.824 1.00 36.24 ? 601 LEU A CG  1 
ATOM 4291 C CD1 . LEU A 1 558 ? 111.042 112.803 104.197 1.00 46.60 ? 601 LEU A CD1 1 
ATOM 4292 C CD2 . LEU A 1 558 ? 108.634 113.475 104.197 1.00 40.84 ? 601 LEU A CD2 1 
ATOM 4293 N N   . GLN A 1 559 ? 109.823 118.468 105.522 1.00 41.44 ? 602 GLN A N   1 
ATOM 4294 C CA  . GLN A 1 559 ? 110.002 119.404 106.623 1.00 29.21 ? 602 GLN A CA  1 
ATOM 4295 C C   . GLN A 1 559 ? 108.691 119.763 107.304 1.00 39.51 ? 602 GLN A C   1 
ATOM 4296 O O   . GLN A 1 559 ? 108.708 120.204 108.457 1.00 45.40 ? 602 GLN A O   1 
ATOM 4297 C CB  . GLN A 1 559 ? 110.690 120.678 106.129 1.00 31.29 ? 602 GLN A CB  1 
ATOM 4298 C CG  . GLN A 1 559 ? 109.900 121.445 105.087 1.00 42.49 ? 602 GLN A CG  1 
ATOM 4299 C CD  . GLN A 1 559 ? 110.602 121.493 103.747 1.00 45.08 ? 602 GLN A CD  1 
ATOM 4300 O OE1 . GLN A 1 559 ? 111.367 120.594 103.403 1.00 49.71 ? 602 GLN A OE1 1 
ATOM 4301 N NE2 . GLN A 1 559 ? 110.345 122.546 102.982 1.00 42.42 ? 602 GLN A NE2 1 
ATOM 4302 N N   . LYS A 1 560 ? 107.562 119.586 106.621 1.00 36.81 ? 603 LYS A N   1 
ATOM 4303 C CA  . LYS A 1 560 ? 106.248 119.839 107.190 1.00 32.75 ? 603 LYS A CA  1 
ATOM 4304 C C   . LYS A 1 560 ? 105.555 118.563 107.644 1.00 34.31 ? 603 LYS A C   1 
ATOM 4305 O O   . LYS A 1 560 ? 104.382 118.609 108.027 1.00 43.55 ? 603 LYS A O   1 
ATOM 4306 C CB  . LYS A 1 560 ? 105.369 120.579 106.182 1.00 37.05 ? 603 LYS A CB  1 
ATOM 4307 C CG  . LYS A 1 560 ? 106.147 121.350 105.132 1.00 41.49 ? 603 LYS A CG  1 
ATOM 4308 C CD  . LYS A 1 560 ? 105.325 122.494 104.569 1.00 39.40 ? 603 LYS A CD  1 
ATOM 4309 C CE  . LYS A 1 560 ? 106.161 123.373 103.658 1.00 41.58 ? 603 LYS A CE  1 
ATOM 4310 N NZ  . LYS A 1 560 ? 105.313 124.232 102.789 1.00 40.29 ? 603 LYS A NZ  1 
ATOM 4311 N N   . GLY A 1 561 ? 106.250 117.426 107.606 1.00 38.33 ? 604 GLY A N   1 
ATOM 4312 C CA  . GLY A 1 561 ? 105.677 116.167 108.025 1.00 36.78 ? 604 GLY A CA  1 
ATOM 4313 C C   . GLY A 1 561 ? 105.849 115.915 109.510 1.00 39.41 ? 604 GLY A C   1 
ATOM 4314 O O   . GLY A 1 561 ? 106.455 116.694 110.244 1.00 46.62 ? 604 GLY A O   1 
ATOM 4315 N N   . ARG A 1 562 ? 105.299 114.789 109.952 1.00 40.17 ? 605 ARG A N   1 
ATOM 4316 C CA  . ARG A 1 562 ? 105.331 114.394 111.353 1.00 37.69 ? 605 ARG A CA  1 
ATOM 4317 C C   . ARG A 1 562 ? 106.482 113.425 111.585 1.00 43.64 ? 605 ARG A C   1 
ATOM 4318 O O   . ARG A 1 562 ? 106.624 112.436 110.859 1.00 52.83 ? 605 ARG A O   1 
ATOM 4319 C CB  . ARG A 1 562 ? 104.006 113.756 111.768 1.00 35.70 ? 605 ARG A CB  1 
ATOM 4320 C CG  . ARG A 1 562 ? 104.044 113.072 113.117 1.00 37.31 ? 605 ARG A CG  1 
ATOM 4321 C CD  . ARG A 1 562 ? 102.651 112.919 113.692 1.00 40.43 ? 605 ARG A CD  1 
ATOM 4322 N NE  . ARG A 1 562 ? 102.026 111.671 113.274 1.00 48.65 ? 605 ARG A NE  1 
ATOM 4323 C CZ  . ARG A 1 562 ? 102.161 110.516 113.911 1.00 48.87 ? 605 ARG A CZ  1 
ATOM 4324 N NH1 . ARG A 1 562 ? 102.892 110.414 115.008 1.00 42.51 ? 605 ARG A NH1 1 
ATOM 4325 N NH2 . ARG A 1 562 ? 101.547 109.437 113.436 1.00 45.63 ? 605 ARG A NH2 1 
ATOM 4326 N N   . PHE A 1 563 ? 107.296 113.714 112.595 1.00 36.10 ? 606 PHE A N   1 
ATOM 4327 C CA  . PHE A 1 563 ? 108.452 112.893 112.925 1.00 29.31 ? 606 PHE A CA  1 
ATOM 4328 C C   . PHE A 1 563 ? 108.048 111.798 113.903 1.00 39.57 ? 606 PHE A C   1 
ATOM 4329 O O   . PHE A 1 563 ? 107.456 112.078 114.950 1.00 46.25 ? 606 PHE A O   1 
ATOM 4330 C CB  . PHE A 1 563 ? 109.564 113.756 113.522 1.00 33.55 ? 606 PHE A CB  1 
ATOM 4331 C CG  . PHE A 1 563 ? 110.883 113.050 113.652 1.00 38.43 ? 606 PHE A CG  1 
ATOM 4332 C CD1 . PHE A 1 563 ? 111.166 112.279 114.765 1.00 38.70 ? 606 PHE A CD1 1 
ATOM 4333 C CD2 . PHE A 1 563 ? 111.844 113.167 112.665 1.00 41.02 ? 606 PHE A CD2 1 
ATOM 4334 C CE1 . PHE A 1 563 ? 112.377 111.634 114.887 1.00 39.08 ? 606 PHE A CE1 1 
ATOM 4335 C CE2 . PHE A 1 563 ? 113.058 112.525 112.783 1.00 39.88 ? 606 PHE A CE2 1 
ATOM 4336 C CZ  . PHE A 1 563 ? 113.324 111.757 113.895 1.00 40.85 ? 606 PHE A CZ  1 
ATOM 4337 N N   . ILE A 1 564 ? 108.371 110.554 113.558 1.00 33.93 ? 607 ILE A N   1 
ATOM 4338 C CA  . ILE A 1 564 ? 108.141 109.403 114.422 1.00 30.56 ? 607 ILE A CA  1 
ATOM 4339 C C   . ILE A 1 564 ? 109.498 108.820 114.782 1.00 39.38 ? 607 ILE A C   1 
ATOM 4340 O O   . ILE A 1 564 ? 110.290 108.484 113.892 1.00 43.72 ? 607 ILE A O   1 
ATOM 4341 C CB  . ILE A 1 564 ? 107.251 108.347 113.750 1.00 37.21 ? 607 ILE A CB  1 
ATOM 4342 C CG1 . ILE A 1 564 ? 106.077 109.014 113.034 1.00 41.94 ? 607 ILE A CG1 1 
ATOM 4343 C CG2 . ILE A 1 564 ? 106.748 107.348 114.775 1.00 40.77 ? 607 ILE A CG2 1 
ATOM 4344 C CD1 . ILE A 1 564 ? 105.025 108.043 112.554 1.00 42.32 ? 607 ILE A CD1 1 
ATOM 4345 N N   . GLY A 1 565 ? 109.769 108.701 116.079 1.00 42.69 ? 608 GLY A N   1 
ATOM 4346 C CA  . GLY A 1 565 ? 111.060 108.217 116.526 1.00 40.97 ? 608 GLY A CA  1 
ATOM 4347 C C   . GLY A 1 565 ? 110.995 107.192 117.638 1.00 46.20 ? 608 GLY A C   1 
ATOM 4348 O O   . GLY A 1 565 ? 112.033 106.718 118.108 1.00 48.57 ? 608 GLY A O   1 
ATOM 4349 N N   . ASP A 1 566 ? 109.787 106.841 118.070 1.00 42.69 ? 609 ASP A N   1 
ATOM 4350 C CA  . ASP A 1 566 ? 109.613 105.869 119.140 1.00 46.94 ? 609 ASP A CA  1 
ATOM 4351 C C   . ASP A 1 566 ? 109.583 104.429 118.647 1.00 47.58 ? 609 ASP A C   1 
ATOM 4352 O O   . ASP A 1 566 ? 109.647 103.509 119.469 1.00 49.25 ? 609 ASP A O   1 
ATOM 4353 C CB  . ASP A 1 566 ? 108.325 106.162 119.916 1.00 47.57 ? 609 ASP A CB  1 
ATOM 4354 C CG  . ASP A 1 566 ? 107.108 106.231 119.019 1.00 49.74 ? 609 ASP A CG  1 
ATOM 4355 O OD1 . ASP A 1 566 ? 107.279 106.266 117.783 1.00 52.72 ? 609 ASP A OD1 1 
ATOM 4356 O OD2 . ASP A 1 566 ? 105.978 106.250 119.549 1.00 51.76 ? 609 ASP A OD2 1 
ATOM 4357 N N   . LEU A 1 567 ? 109.486 104.210 117.335 1.00 43.10 ? 610 LEU A N   1 
ATOM 4358 C CA  . LEU A 1 567 ? 109.359 102.851 116.820 1.00 37.73 ? 610 LEU A CA  1 
ATOM 4359 C C   . LEU A 1 567 ? 110.672 102.087 116.934 1.00 46.49 ? 610 LEU A C   1 
ATOM 4360 O O   . LEU A 1 567 ? 110.694 100.935 117.383 1.00 55.10 ? 610 LEU A O   1 
ATOM 4361 C CB  . LEU A 1 567 ? 108.882 102.886 115.370 1.00 43.07 ? 610 LEU A CB  1 
ATOM 4362 C CG  . LEU A 1 567 ? 107.408 103.223 115.149 1.00 47.17 ? 610 LEU A CG  1 
ATOM 4363 C CD1 . LEU A 1 567 ? 107.041 103.058 113.687 1.00 48.10 ? 610 LEU A CD1 1 
ATOM 4364 C CD2 . LEU A 1 567 ? 106.526 102.355 116.027 1.00 46.81 ? 610 LEU A CD2 1 
ATOM 4365 N N   . TYR A 1 568 ? 111.777 102.707 116.534 1.00 41.22 ? 611 TYR A N   1 
ATOM 4366 C CA  . TYR A 1 568 ? 113.066 102.033 116.474 1.00 38.99 ? 611 TYR A CA  1 
ATOM 4367 C C   . TYR A 1 568 ? 113.978 102.551 117.581 1.00 50.13 ? 611 TYR A C   1 
ATOM 4368 O O   . TYR A 1 568 ? 113.711 103.575 118.215 1.00 55.38 ? 611 TYR A O   1 
ATOM 4369 C CB  . TYR A 1 568 ? 113.734 102.224 115.104 1.00 43.60 ? 611 TYR A CB  1 
ATOM 4370 C CG  . TYR A 1 568 ? 113.010 101.608 113.914 1.00 52.87 ? 611 TYR A CG  1 
ATOM 4371 C CD1 . TYR A 1 568 ? 113.654 101.457 112.697 1.00 44.77 ? 611 TYR A CD1 1 
ATOM 4372 C CD2 . TYR A 1 568 ? 111.686 101.205 113.996 1.00 56.08 ? 611 TYR A CD2 1 
ATOM 4373 C CE1 . TYR A 1 568 ? 113.016 100.913 111.607 1.00 45.60 ? 611 TYR A CE1 1 
ATOM 4374 C CE2 . TYR A 1 568 ? 111.038 100.666 112.909 1.00 51.65 ? 611 TYR A CE2 1 
ATOM 4375 C CZ  . TYR A 1 568 ? 111.708 100.517 111.717 1.00 49.83 ? 611 TYR A CZ  1 
ATOM 4376 O OH  . TYR A 1 568 ? 111.064 99.973  110.631 1.00 54.68 ? 611 TYR A OH  1 
ATOM 4377 N N   . SER A 1 569 ? 115.068 101.823 117.809 1.00 48.42 ? 612 SER A N   1 
ATOM 4378 C CA  . SER A 1 569 ? 116.045 102.155 118.837 1.00 39.16 ? 612 SER A CA  1 
ATOM 4379 C C   . SER A 1 569 ? 117.411 102.345 118.196 1.00 37.41 ? 612 SER A C   1 
ATOM 4380 O O   . SER A 1 569 ? 117.824 101.539 117.357 1.00 48.63 ? 612 SER A O   1 
ATOM 4381 C CB  . SER A 1 569 ? 116.112 101.064 119.907 1.00 46.23 ? 612 SER A CB  1 
ATOM 4382 O OG  . SER A 1 569 ? 117.275 101.203 120.703 1.00 51.50 ? 612 SER A OG  1 
ATOM 4383 N N   . TYR A 1 570 ? 118.107 103.405 118.595 1.00 34.76 ? 613 TYR A N   1 
ATOM 4384 C CA  . TYR A 1 570 ? 119.427 103.694 118.053 1.00 37.68 ? 613 TYR A CA  1 
ATOM 4385 C C   . TYR A 1 570 ? 120.490 102.895 118.794 1.00 42.53 ? 613 TYR A C   1 
ATOM 4386 O O   . TYR A 1 570 ? 120.507 102.860 120.028 1.00 47.48 ? 613 TYR A O   1 
ATOM 4387 C CB  . TYR A 1 570 ? 119.728 105.189 118.148 1.00 35.81 ? 613 TYR A CB  1 
ATOM 4388 C CG  . TYR A 1 570 ? 121.078 105.566 117.591 1.00 23.39 ? 613 TYR A CG  1 
ATOM 4389 C CD1 . TYR A 1 570 ? 121.309 105.574 116.226 1.00 35.04 ? 613 TYR A CD1 1 
ATOM 4390 C CD2 . TYR A 1 570 ? 122.124 105.909 118.431 1.00 36.68 ? 613 TYR A CD2 1 
ATOM 4391 C CE1 . TYR A 1 570 ? 122.541 105.914 115.713 1.00 36.49 ? 613 TYR A CE1 1 
ATOM 4392 C CE2 . TYR A 1 570 ? 123.360 106.250 117.927 1.00 41.21 ? 613 TYR A CE2 1 
ATOM 4393 C CZ  . TYR A 1 570 ? 123.563 106.250 116.569 1.00 33.84 ? 613 TYR A CZ  1 
ATOM 4394 O OH  . TYR A 1 570 ? 124.794 106.592 116.064 1.00 42.37 ? 613 TYR A OH  1 
ATOM 4395 N N   . GLY A 1 571 ? 121.378 102.252 118.036 1.00 41.13 ? 614 GLY A N   1 
ATOM 4396 C CA  . GLY A 1 571 ? 122.454 101.472 118.602 1.00 39.26 ? 614 GLY A CA  1 
ATOM 4397 C C   . GLY A 1 571 ? 122.112 100.032 118.908 1.00 40.00 ? 614 GLY A C   1 
ATOM 4398 O O   . GLY A 1 571 ? 123.011 99.265  119.276 1.00 51.33 ? 614 GLY A O   1 
ATOM 4399 N N   . PHE A 1 572 ? 120.849 99.636  118.769 1.00 36.68 ? 615 PHE A N   1 
ATOM 4400 C CA  . PHE A 1 572 ? 120.432 98.257  118.984 1.00 45.44 ? 615 PHE A CA  1 
ATOM 4401 C C   . PHE A 1 572 ? 119.518 97.785  117.861 1.00 51.98 ? 615 PHE A C   1 
ATOM 4402 O O   . PHE A 1 572 ? 118.701 96.881  118.051 1.00 54.33 ? 615 PHE A O   1 
ATOM 4403 C CB  . PHE A 1 572 ? 119.753 98.099  120.343 1.00 49.46 ? 615 PHE A CB  1 
ATOM 4404 C CG  . PHE A 1 572 ? 120.681 98.298  121.505 1.00 47.20 ? 615 PHE A CG  1 
ATOM 4405 C CD1 . PHE A 1 572 ? 121.521 97.280  121.919 1.00 46.79 ? 615 PHE A CD1 1 
ATOM 4406 C CD2 . PHE A 1 572 ? 120.724 99.508  122.173 1.00 47.90 ? 615 PHE A CD2 1 
ATOM 4407 C CE1 . PHE A 1 572 ? 122.378 97.462  122.982 1.00 44.71 ? 615 PHE A CE1 1 
ATOM 4408 C CE2 . PHE A 1 572 ? 121.580 99.695  123.235 1.00 47.46 ? 615 PHE A CE2 1 
ATOM 4409 C CZ  . PHE A 1 572 ? 122.407 98.671  123.641 1.00 45.53 ? 615 PHE A CZ  1 
ATOM 4410 N N   . ASP A 1 573 ? 119.647 98.392  116.690 1.00 50.56 ? 616 ASP A N   1 
ATOM 4411 C CA  . ASP A 1 573 ? 118.892 98.048  115.497 1.00 48.91 ? 616 ASP A CA  1 
ATOM 4412 C C   . ASP A 1 573 ? 119.861 97.889  114.338 1.00 49.69 ? 616 ASP A C   1 
ATOM 4413 O O   . ASP A 1 573 ? 120.961 98.453  114.359 1.00 58.86 ? 616 ASP A O   1 
ATOM 4414 C CB  . ASP A 1 573 ? 117.844 99.123  115.174 1.00 51.84 ? 616 ASP A CB  1 
ATOM 4415 C CG  . ASP A 1 573 ? 116.455 98.741  115.648 1.00 55.42 ? 616 ASP A CG  1 
ATOM 4416 O OD1 . ASP A 1 573 ? 116.185 97.530  115.785 1.00 55.74 ? 616 ASP A OD1 1 
ATOM 4417 O OD2 . ASP A 1 573 ? 115.633 99.650  115.886 1.00 53.83 ? 616 ASP A OD2 1 
ATOM 4418 N N   . PRO A 1 574 ? 119.492 97.112  113.315 1.00 33.42 ? 617 PRO A N   1 
ATOM 4419 C CA  . PRO A 1 574 ? 120.442 96.849  112.222 1.00 34.89 ? 617 PRO A CA  1 
ATOM 4420 C C   . PRO A 1 574 ? 120.936 98.097  111.514 1.00 39.90 ? 617 PRO A C   1 
ATOM 4421 O O   . PRO A 1 574 ? 122.094 98.130  111.083 1.00 50.84 ? 617 PRO A O   1 
ATOM 4422 C CB  . PRO A 1 574 ? 119.639 95.946  111.276 1.00 47.95 ? 617 PRO A CB  1 
ATOM 4423 C CG  . PRO A 1 574 ? 118.620 95.303  112.147 1.00 47.47 ? 617 PRO A CG  1 
ATOM 4424 C CD  . PRO A 1 574 ? 118.248 96.338  113.161 1.00 40.33 ? 617 PRO A CD  1 
ATOM 4425 N N   . TYR A 1 575 ? 120.103 99.124  111.380 1.00 39.72 ? 618 TYR A N   1 
ATOM 4426 C CA  . TYR A 1 575 ? 120.478 100.335 110.667 1.00 43.48 ? 618 TYR A CA  1 
ATOM 4427 C C   . TYR A 1 575 ? 120.082 101.560 111.480 1.00 52.94 ? 618 TYR A C   1 
ATOM 4428 O O   . TYR A 1 575 ? 119.205 101.502 112.346 1.00 53.91 ? 618 TYR A O   1 
ATOM 4429 C CB  . TYR A 1 575 ? 119.816 100.402 109.284 1.00 42.87 ? 618 TYR A CB  1 
ATOM 4430 C CG  . TYR A 1 575 ? 120.366 99.423  108.273 1.00 45.06 ? 618 TYR A CG  1 
ATOM 4431 C CD1 . TYR A 1 575 ? 121.498 99.724  107.532 1.00 47.87 ? 618 TYR A CD1 1 
ATOM 4432 C CD2 . TYR A 1 575 ? 119.742 98.205  108.048 1.00 45.59 ? 618 TYR A CD2 1 
ATOM 4433 C CE1 . TYR A 1 575 ? 122.000 98.835  106.605 1.00 46.54 ? 618 TYR A CE1 1 
ATOM 4434 C CE2 . TYR A 1 575 ? 120.237 97.310  107.122 1.00 46.37 ? 618 TYR A CE2 1 
ATOM 4435 C CZ  . TYR A 1 575 ? 121.366 97.631  106.403 1.00 48.01 ? 618 TYR A CZ  1 
ATOM 4436 O OH  . TYR A 1 575 ? 121.865 96.744  105.478 1.00 53.35 ? 618 TYR A OH  1 
ATOM 4437 N N   . GLU A 1 576 ? 120.747 102.675 111.191 1.00 51.34 ? 619 GLU A N   1 
ATOM 4438 C CA  . GLU A 1 576 ? 120.350 103.969 111.732 1.00 43.32 ? 619 GLU A CA  1 
ATOM 4439 C C   . GLU A 1 576 ? 119.140 104.469 110.953 1.00 45.02 ? 619 GLU A C   1 
ATOM 4440 O O   . GLU A 1 576 ? 119.218 104.663 109.735 1.00 53.85 ? 619 GLU A O   1 
ATOM 4441 C CB  . GLU A 1 576 ? 121.507 104.960 111.645 1.00 41.93 ? 619 GLU A CB  1 
ATOM 4442 C CG  . GLU A 1 576 ? 121.191 106.339 112.189 1.00 49.04 ? 619 GLU A CG  1 
ATOM 4443 C CD  . GLU A 1 576 ? 122.400 107.249 112.199 1.00 51.77 ? 619 GLU A CD  1 
ATOM 4444 O OE1 . GLU A 1 576 ? 123.535 106.730 112.200 1.00 49.16 ? 619 GLU A OE1 1 
ATOM 4445 O OE2 . GLU A 1 576 ? 122.217 108.483 112.203 1.00 53.88 ? 619 GLU A OE2 1 
ATOM 4446 N N   . THR A 1 577 ? 118.024 104.680 111.649 1.00 39.83 ? 620 THR A N   1 
ATOM 4447 C CA  . THR A 1 577 ? 116.731 104.841 111.003 1.00 39.12 ? 620 THR A CA  1 
ATOM 4448 C C   . THR A 1 577 ? 116.034 106.115 111.457 1.00 48.66 ? 620 THR A C   1 
ATOM 4449 O O   . THR A 1 577 ? 116.218 106.577 112.586 1.00 53.60 ? 620 THR A O   1 
ATOM 4450 C CB  . THR A 1 577 ? 115.825 103.661 111.305 1.00 39.58 ? 620 THR A CB  1 
ATOM 4451 O OG1 . THR A 1 577 ? 115.649 103.569 112.723 1.00 46.45 ? 620 THR A OG1 1 
ATOM 4452 C CG2 . THR A 1 577 ? 116.441 102.371 110.792 1.00 43.56 ? 620 THR A CG2 1 
ATOM 4453 N N   . TYR A 1 578 ? 115.215 106.664 110.560 1.00 42.67 ? 621 TYR A N   1 
ATOM 4454 C CA  . TYR A 1 578 ? 114.390 107.833 110.841 1.00 34.52 ? 621 TYR A CA  1 
ATOM 4455 C C   . TYR A 1 578 ? 113.107 107.720 110.033 1.00 39.59 ? 621 TYR A C   1 
ATOM 4456 O O   . TYR A 1 578 ? 113.155 107.425 108.836 1.00 46.37 ? 621 TYR A O   1 
ATOM 4457 C CB  . TYR A 1 578 ? 115.133 109.129 110.503 1.00 33.55 ? 621 TYR A CB  1 
ATOM 4458 C CG  . TYR A 1 578 ? 116.469 109.247 111.196 1.00 36.60 ? 621 TYR A CG  1 
ATOM 4459 C CD1 . TYR A 1 578 ? 116.552 109.670 112.513 1.00 38.95 ? 621 TYR A CD1 1 
ATOM 4460 C CD2 . TYR A 1 578 ? 117.644 108.917 110.539 1.00 42.24 ? 621 TYR A CD2 1 
ATOM 4461 C CE1 . TYR A 1 578 ? 117.767 109.769 113.154 1.00 34.65 ? 621 TYR A CE1 1 
ATOM 4462 C CE2 . TYR A 1 578 ? 118.865 109.014 111.172 1.00 38.18 ? 621 TYR A CE2 1 
ATOM 4463 C CZ  . TYR A 1 578 ? 118.920 109.441 112.480 1.00 38.23 ? 621 TYR A CZ  1 
ATOM 4464 O OH  . TYR A 1 578 ? 120.134 109.540 113.117 1.00 50.70 ? 621 TYR A OH  1 
ATOM 4465 N N   . VAL A 1 579 ? 111.969 107.951 110.684 1.00 37.04 ? 622 VAL A N   1 
ATOM 4466 C CA  . VAL A 1 579 ? 110.655 107.764 110.078 1.00 25.43 ? 622 VAL A CA  1 
ATOM 4467 C C   . VAL A 1 579 ? 109.902 109.086 110.094 1.00 41.60 ? 622 VAL A C   1 
ATOM 4468 O O   . VAL A 1 579 ? 109.819 109.753 111.131 1.00 50.32 ? 622 VAL A O   1 
ATOM 4469 C CB  . VAL A 1 579 ? 109.844 106.673 110.805 1.00 22.14 ? 622 VAL A CB  1 
ATOM 4470 C CG1 . VAL A 1 579 ? 108.623 106.295 109.990 1.00 35.71 ? 622 VAL A CG1 1 
ATOM 4471 C CG2 . VAL A 1 579 ? 110.710 105.456 111.070 1.00 38.80 ? 622 VAL A CG2 1 
ATOM 4472 N N   . VAL A 1 580 ? 109.351 109.459 108.939 1.00 45.47 ? 623 VAL A N   1 
ATOM 4473 C CA  . VAL A 1 580 ? 108.560 110.676 108.785 1.00 33.65 ? 623 VAL A CA  1 
ATOM 4474 C C   . VAL A 1 580 ? 107.238 110.308 108.125 1.00 35.43 ? 623 VAL A C   1 
ATOM 4475 O O   . VAL A 1 580 ? 107.215 109.529 107.167 1.00 46.21 ? 623 VAL A O   1 
ATOM 4476 C CB  . VAL A 1 580 ? 109.295 111.744 107.950 1.00 26.66 ? 623 VAL A CB  1 
ATOM 4477 C CG1 . VAL A 1 580 ? 108.503 113.037 107.926 1.00 37.25 ? 623 VAL A CG1 1 
ATOM 4478 C CG2 . VAL A 1 580 ? 110.691 111.987 108.494 1.00 35.21 ? 623 VAL A CG2 1 
ATOM 4479 N N   . GLU A 1 581 ? 106.141 110.859 108.637 1.00 31.09 ? 624 GLU A N   1 
ATOM 4480 C CA  . GLU A 1 581 ? 104.814 110.647 108.073 1.00 30.75 ? 624 GLU A CA  1 
ATOM 4481 C C   . GLU A 1 581 ? 104.341 111.935 107.411 1.00 41.70 ? 624 GLU A C   1 
ATOM 4482 O O   . GLU A 1 581 ? 104.397 113.007 108.022 1.00 48.03 ? 624 GLU A O   1 
ATOM 4483 C CB  . GLU A 1 581 ? 103.826 110.207 109.151 1.00 30.71 ? 624 GLU A CB  1 
ATOM 4484 C CG  . GLU A 1 581 ? 102.395 110.084 108.664 1.00 35.41 ? 624 GLU A CG  1 
ATOM 4485 C CD  . GLU A 1 581 ? 101.570 111.319 108.960 1.00 48.40 ? 624 GLU A CD  1 
ATOM 4486 O OE1 . GLU A 1 581 ? 101.784 111.938 110.023 1.00 49.59 ? 624 GLU A OE1 1 
ATOM 4487 O OE2 . GLU A 1 581 ? 100.708 111.674 108.128 1.00 48.95 ? 624 GLU A OE2 1 
ATOM 4488 N N   . LYS A 1 582 ? 103.878 111.829 106.167 1.00 51.72 ? 625 LYS A N   1 
ATOM 4489 C CA  . LYS A 1 582 ? 103.395 112.974 105.394 1.00 38.43 ? 625 LYS A CA  1 
ATOM 4490 C C   . LYS A 1 582 ? 102.138 112.556 104.634 1.00 45.95 ? 625 LYS A C   1 
ATOM 4491 O O   . LYS A 1 582 ? 102.202 111.765 103.690 1.00 50.41 ? 625 LYS A O   1 
ATOM 4492 C CB  . LYS A 1 582 ? 104.471 113.484 104.457 1.00 31.77 ? 625 LYS A CB  1 
ATOM 4493 C CG  . LYS A 1 582 ? 104.007 114.603 103.552 1.00 36.31 ? 625 LYS A CG  1 
ATOM 4494 C CD  . LYS A 1 582 ? 104.296 115.954 104.172 1.00 46.87 ? 625 LYS A CD  1 
ATOM 4495 C CE  . LYS A 1 582 ? 103.311 117.005 103.697 1.00 46.36 ? 625 LYS A CE  1 
ATOM 4496 N NZ  . LYS A 1 582 ? 103.932 117.954 102.740 1.00 47.58 ? 625 LYS A NZ  1 
ATOM 4497 N N   . ASP A 1 583 ? 100.995 113.101 105.056 1.00 50.59 ? 626 ASP A N   1 
ATOM 4498 C CA  . ASP A 1 583 ? 99.710  112.876 104.403 1.00 46.39 ? 626 ASP A CA  1 
ATOM 4499 C C   . ASP A 1 583 ? 99.357  111.397 104.318 1.00 49.99 ? 626 ASP A C   1 
ATOM 4500 O O   . ASP A 1 583 ? 98.872  110.928 103.284 1.00 53.36 ? 626 ASP A O   1 
ATOM 4501 C CB  . ASP A 1 583 ? 99.706  113.499 103.004 1.00 52.25 ? 626 ASP A CB  1 
ATOM 4502 C CG  . ASP A 1 583 ? 100.051 114.974 103.024 1.00 59.27 ? 626 ASP A CG  1 
ATOM 4503 O OD1 . ASP A 1 583 ? 100.539 115.456 104.067 1.00 56.98 ? 626 ASP A OD1 1 
ATOM 4504 O OD2 . ASP A 1 583 ? 99.836  115.651 101.997 1.00 57.88 ? 626 ASP A OD2 1 
ATOM 4505 N N   . GLY A 1 584 ? 99.593  110.655 105.396 1.00 42.65 ? 627 GLY A N   1 
ATOM 4506 C CA  . GLY A 1 584 ? 99.253  109.247 105.425 1.00 41.00 ? 627 GLY A CA  1 
ATOM 4507 C C   . GLY A 1 584 ? 100.373 108.342 104.957 1.00 41.55 ? 627 GLY A C   1 
ATOM 4508 O O   . GLY A 1 584 ? 100.601 107.277 105.537 1.00 48.01 ? 627 GLY A O   1 
ATOM 4509 N N   . VAL A 1 585 ? 101.079 108.754 103.905 1.00 43.56 ? 628 VAL A N   1 
ATOM 4510 C CA  . VAL A 1 585 ? 102.171 107.950 103.373 1.00 41.19 ? 628 VAL A CA  1 
ATOM 4511 C C   . VAL A 1 585 ? 103.360 108.026 104.321 1.00 41.26 ? 628 VAL A C   1 
ATOM 4512 O O   . VAL A 1 585 ? 103.806 109.117 104.698 1.00 41.37 ? 628 VAL A O   1 
ATOM 4513 C CB  . VAL A 1 585 ? 102.547 108.422 101.960 1.00 42.15 ? 628 VAL A CB  1 
ATOM 4514 C CG1 . VAL A 1 585 ? 103.937 107.939 101.584 1.00 37.98 ? 628 VAL A CG1 1 
ATOM 4515 C CG2 . VAL A 1 585 ? 101.518 107.938 100.950 1.00 41.57 ? 628 VAL A CG2 1 
ATOM 4516 N N   . MET A 1 586 ? 103.878 106.866 104.710 1.00 40.66 ? 629 MET A N   1 
ATOM 4517 C CA  . MET A 1 586 ? 104.999 106.778 105.633 1.00 33.13 ? 629 MET A CA  1 
ATOM 4518 C C   . MET A 1 586 ? 106.313 106.760 104.863 1.00 32.58 ? 629 MET A C   1 
ATOM 4519 O O   . MET A 1 586 ? 106.439 106.076 103.844 1.00 41.86 ? 629 MET A O   1 
ATOM 4520 C CB  . MET A 1 586 ? 104.889 105.528 106.508 1.00 31.32 ? 629 MET A CB  1 
ATOM 4521 C CG  . MET A 1 586 ? 103.842 105.630 107.603 1.00 29.47 ? 629 MET A CG  1 
ATOM 4522 S SD  . MET A 1 586 ? 104.550 105.940 109.230 1.00 43.96 ? 629 MET A SD  1 
ATOM 4523 C CE  . MET A 1 586 ? 105.417 104.403 109.521 1.00 39.44 ? 629 MET A CE  1 
ATOM 4524 N N   . TYR A 1 587 ? 107.287 107.515 105.358 1.00 25.92 ? 630 TYR A N   1 
ATOM 4525 C CA  . TYR A 1 587 ? 108.603 107.608 104.749 1.00 28.34 ? 630 TYR A CA  1 
ATOM 4526 C C   . TYR A 1 587 ? 109.644 107.015 105.688 1.00 38.10 ? 630 TYR A C   1 
ATOM 4527 O O   . TYR A 1 587 ? 109.544 107.144 106.912 1.00 46.09 ? 630 TYR A O   1 
ATOM 4528 C CB  . TYR A 1 587 ? 108.965 109.063 104.423 1.00 37.95 ? 630 TYR A CB  1 
ATOM 4529 C CG  . TYR A 1 587 ? 108.314 109.603 103.169 1.00 42.00 ? 630 TYR A CG  1 
ATOM 4530 C CD1 . TYR A 1 587 ? 106.980 109.986 103.164 1.00 39.38 ? 630 TYR A CD1 1 
ATOM 4531 C CD2 . TYR A 1 587 ? 109.037 109.736 101.993 1.00 40.80 ? 630 TYR A CD2 1 
ATOM 4532 C CE1 . TYR A 1 587 ? 106.385 110.483 102.022 1.00 38.44 ? 630 TYR A CE1 1 
ATOM 4533 C CE2 . TYR A 1 587 ? 108.450 110.231 100.847 1.00 33.22 ? 630 TYR A CE2 1 
ATOM 4534 C CZ  . TYR A 1 587 ? 107.125 110.601 100.867 1.00 36.96 ? 630 TYR A CZ  1 
ATOM 4535 O OH  . TYR A 1 587 ? 106.539 111.095 99.726  1.00 43.51 ? 630 TYR A OH  1 
ATOM 4536 N N   . TYR A 1 588 ? 110.647 106.363 105.106 1.00 37.03 ? 631 TYR A N   1 
ATOM 4537 C CA  . TYR A 1 588 ? 111.704 105.716 105.867 1.00 22.59 ? 631 TYR A CA  1 
ATOM 4538 C C   . TYR A 1 588 ? 113.061 106.176 105.359 1.00 34.78 ? 631 TYR A C   1 
ATOM 4539 O O   . TYR A 1 588 ? 113.220 106.523 104.187 1.00 49.18 ? 631 TYR A O   1 
ATOM 4540 C CB  . TYR A 1 588 ? 111.616 104.190 105.773 1.00 27.62 ? 631 TYR A CB  1 
ATOM 4541 C CG  . TYR A 1 588 ? 110.332 103.608 106.308 1.00 29.69 ? 631 TYR A CG  1 
ATOM 4542 C CD1 . TYR A 1 588 ? 109.206 103.508 105.506 1.00 41.43 ? 631 TYR A CD1 1 
ATOM 4543 C CD2 . TYR A 1 588 ? 110.248 103.152 107.613 1.00 33.89 ? 631 TYR A CD2 1 
ATOM 4544 C CE1 . TYR A 1 588 ? 108.031 102.975 105.992 1.00 39.60 ? 631 TYR A CE1 1 
ATOM 4545 C CE2 . TYR A 1 588 ? 109.079 102.619 108.106 1.00 37.89 ? 631 TYR A CE2 1 
ATOM 4546 C CZ  . TYR A 1 588 ? 107.974 102.533 107.292 1.00 38.52 ? 631 TYR A CZ  1 
ATOM 4547 O OH  . TYR A 1 588 ? 106.807 101.999 107.781 1.00 47.80 ? 631 TYR A OH  1 
ATOM 4548 N N   . ALA A 1 589 ? 114.042 106.172 106.259 1.00 38.26 ? 632 ALA A N   1 
ATOM 4549 C CA  . ALA A 1 589 ? 115.416 106.521 105.918 1.00 34.13 ? 632 ALA A CA  1 
ATOM 4550 C C   . ALA A 1 589 ? 116.354 105.602 106.682 1.00 38.13 ? 632 ALA A C   1 
ATOM 4551 O O   . ALA A 1 589 ? 116.380 105.629 107.915 1.00 41.61 ? 632 ALA A O   1 
ATOM 4552 C CB  . ALA A 1 589 ? 115.715 107.987 106.241 1.00 37.53 ? 632 ALA A CB  1 
ATOM 4553 N N   . PHE A 1 590 ? 117.119 104.796 105.954 1.00 36.60 ? 633 PHE A N   1 
ATOM 4554 C CA  . PHE A 1 590 ? 118.104 103.897 106.536 1.00 28.61 ? 633 PHE A CA  1 
ATOM 4555 C C   . PHE A 1 590 ? 119.497 104.370 106.152 1.00 41.47 ? 633 PHE A C   1 
ATOM 4556 O O   . PHE A 1 590 ? 119.721 104.802 105.017 1.00 57.13 ? 633 PHE A O   1 
ATOM 4557 C CB  . PHE A 1 590 ? 117.886 102.460 106.063 1.00 33.61 ? 633 PHE A CB  1 
ATOM 4558 C CG  . PHE A 1 590 ? 116.472 101.987 106.202 1.00 32.94 ? 633 PHE A CG  1 
ATOM 4559 C CD1 . PHE A 1 590 ? 116.000 101.528 107.416 1.00 33.77 ? 633 PHE A CD1 1 
ATOM 4560 C CD2 . PHE A 1 590 ? 115.615 102.000 105.118 1.00 42.65 ? 633 PHE A CD2 1 
ATOM 4561 C CE1 . PHE A 1 590 ? 114.701 101.094 107.548 1.00 34.81 ? 633 PHE A CE1 1 
ATOM 4562 C CE2 . PHE A 1 590 ? 114.314 101.566 105.244 1.00 47.40 ? 633 PHE A CE2 1 
ATOM 4563 C CZ  . PHE A 1 590 ? 113.857 101.113 106.461 1.00 40.42 ? 633 PHE A CZ  1 
ATOM 4564 N N   . TYR A 1 591 ? 120.431 104.290 107.094 1.00 34.48 ? 634 TYR A N   1 
ATOM 4565 C CA  . TYR A 1 591 ? 121.757 104.849 106.894 1.00 35.42 ? 634 TYR A CA  1 
ATOM 4566 C C   . TYR A 1 591 ? 122.829 103.850 107.303 1.00 38.55 ? 634 TYR A C   1 
ATOM 4567 O O   . TYR A 1 591 ? 122.614 102.994 108.163 1.00 44.90 ? 634 TYR A O   1 
ATOM 4568 C CB  . TYR A 1 591 ? 121.925 106.155 107.674 1.00 40.64 ? 634 TYR A CB  1 
ATOM 4569 C CG  . TYR A 1 591 ? 121.131 107.299 107.090 1.00 42.59 ? 634 TYR A CG  1 
ATOM 4570 C CD1 . TYR A 1 591 ? 121.542 107.929 105.925 1.00 43.76 ? 634 TYR A CD1 1 
ATOM 4571 C CD2 . TYR A 1 591 ? 119.964 107.742 107.697 1.00 43.34 ? 634 TYR A CD2 1 
ATOM 4572 C CE1 . TYR A 1 591 ? 120.819 108.971 105.385 1.00 46.29 ? 634 TYR A CE1 1 
ATOM 4573 C CE2 . TYR A 1 591 ? 119.234 108.783 107.163 1.00 44.04 ? 634 TYR A CE2 1 
ATOM 4574 C CZ  . TYR A 1 591 ? 119.666 109.394 106.008 1.00 47.42 ? 634 TYR A CZ  1 
ATOM 4575 O OH  . TYR A 1 591 ? 118.942 110.433 105.472 1.00 48.76 ? 634 TYR A OH  1 
ATOM 4576 N N   . LYS A 1 592 ? 123.993 103.976 106.664 1.00 45.20 ? 635 LYS A N   1 
ATOM 4577 C CA  . LYS A 1 592 ? 125.140 103.124 106.938 1.00 40.48 ? 635 LYS A CA  1 
ATOM 4578 C C   . LYS A 1 592 ? 126.447 103.888 107.082 1.00 48.43 ? 635 LYS A C   1 
ATOM 4579 O O   . LYS A 1 592 ? 127.434 103.298 107.534 1.00 52.29 ? 635 LYS A O   1 
ATOM 4580 C CB  . LYS A 1 592 ? 125.307 102.074 105.829 1.00 45.44 ? 635 LYS A CB  1 
ATOM 4581 C CG  . LYS A 1 592 ? 124.968 100.660 106.250 1.00 53.22 ? 635 LYS A CG  1 
ATOM 4582 C CD  . LYS A 1 592 ? 125.848 99.651  105.532 1.00 51.47 ? 635 LYS A CD  1 
ATOM 4583 C CE  . LYS A 1 592 ? 125.032 98.765  104.607 1.00 52.89 ? 635 LYS A CE  1 
ATOM 4584 N NZ  . LYS A 1 592 ? 125.901 97.896  103.767 1.00 52.83 ? 635 LYS A NZ  1 
ATOM 4585 N N   . ASP A 1 593 ? 126.491 105.167 106.714 1.00 60.62 ? 636 ASP A N   1 
ATOM 4586 C CA  . ASP A 1 593 ? 127.704 105.970 106.792 1.00 59.71 ? 636 ASP A CA  1 
ATOM 4587 C C   . ASP A 1 593 ? 127.928 106.569 108.173 1.00 60.85 ? 636 ASP A C   1 
ATOM 4588 O O   . ASP A 1 593 ? 128.799 107.431 108.326 1.00 63.16 ? 636 ASP A O   1 
ATOM 4589 C CB  . ASP A 1 593 ? 127.663 107.086 105.745 1.00 64.64 ? 636 ASP A CB  1 
ATOM 4590 C CG  . ASP A 1 593 ? 128.552 106.798 104.553 1.00 69.92 ? 636 ASP A CG  1 
ATOM 4591 O OD1 . ASP A 1 593 ? 128.974 105.634 104.391 1.00 69.34 ? 636 ASP A OD1 1 
ATOM 4592 O OD2 . ASP A 1 593 ? 128.830 107.736 103.776 1.00 72.11 ? 636 ASP A OD2 1 
ATOM 4593 N N   . GLY A 1 594 ? 127.168 106.132 109.172 1.00 62.30 ? 637 GLY A N   1 
ATOM 4594 C CA  . GLY A 1 594 ? 127.326 106.612 110.530 1.00 63.24 ? 637 GLY A CA  1 
ATOM 4595 C C   . GLY A 1 594 ? 128.459 105.916 111.252 1.00 66.28 ? 637 GLY A C   1 
ATOM 4596 O O   . GLY A 1 594 ? 128.221 105.001 112.044 1.00 70.39 ? 637 GLY A O   1 
ATOM 4597 N N   . SER A 1 595 ? 129.695 106.335 110.971 1.00 58.70 ? 638 SER A N   1 
ATOM 4598 C CA  . SER A 1 595 ? 130.909 105.699 111.476 1.00 55.10 ? 638 SER A CA  1 
ATOM 4599 C C   . SER A 1 595 ? 130.842 105.353 112.960 1.00 54.18 ? 638 SER A C   1 
ATOM 4600 O O   . SER A 1 595 ? 131.492 104.401 113.405 1.00 58.96 ? 638 SER A O   1 
ATOM 4601 C CB  . SER A 1 595 ? 132.117 106.600 111.216 1.00 54.44 ? 638 SER A CB  1 
ATOM 4602 O OG  . SER A 1 595 ? 132.003 107.819 111.928 1.00 54.47 ? 638 SER A OG  1 
ATOM 4603 N N   . LYS A 1 596 ? 130.072 106.119 113.736 1.00 45.89 ? 639 LYS A N   1 
ATOM 4604 C CA  . LYS A 1 596 ? 129.895 105.788 115.146 1.00 48.67 ? 639 LYS A CA  1 
ATOM 4605 C C   . LYS A 1 596 ? 129.173 104.457 115.315 1.00 49.98 ? 639 LYS A C   1 
ATOM 4606 O O   . LYS A 1 596 ? 129.533 103.654 116.182 1.00 50.83 ? 639 LYS A O   1 
ATOM 4607 C CB  . LYS A 1 596 ? 129.136 106.906 115.859 1.00 51.22 ? 639 LYS A CB  1 
ATOM 4608 C CG  . LYS A 1 596 ? 129.956 107.641 116.905 1.00 53.05 ? 639 LYS A CG  1 
ATOM 4609 C CD  . LYS A 1 596 ? 131.347 107.968 116.386 1.00 53.15 ? 639 LYS A CD  1 
ATOM 4610 C CE  . LYS A 1 596 ? 132.104 108.854 117.358 1.00 52.47 ? 639 LYS A CE  1 
ATOM 4611 N NZ  . LYS A 1 596 ? 133.548 108.498 117.426 1.00 49.22 ? 639 LYS A NZ  1 
ATOM 4612 N N   . TYR A 1 597 ? 128.151 104.203 114.498 1.00 47.39 ? 640 TYR A N   1 
ATOM 4613 C CA  . TYR A 1 597 ? 127.399 102.948 114.555 1.00 47.50 ? 640 TYR A CA  1 
ATOM 4614 C C   . TYR A 1 597 ? 127.081 102.507 113.129 1.00 52.83 ? 640 TYR A C   1 
ATOM 4615 O O   . TYR A 1 597 ? 126.136 103.010 112.514 1.00 55.58 ? 640 TYR A O   1 
ATOM 4616 C CB  . TYR A 1 597 ? 126.126 103.095 115.377 1.00 48.02 ? 640 TYR A CB  1 
ATOM 4617 C CG  . TYR A 1 597 ? 125.332 101.815 115.464 1.00 49.65 ? 640 TYR A CG  1 
ATOM 4618 C CD1 . TYR A 1 597 ? 125.767 100.756 116.251 1.00 53.44 ? 640 TYR A CD1 1 
ATOM 4619 C CD2 . TYR A 1 597 ? 124.155 101.660 114.752 1.00 51.17 ? 640 TYR A CD2 1 
ATOM 4620 C CE1 . TYR A 1 597 ? 125.044 99.582  116.328 1.00 54.49 ? 640 TYR A CE1 1 
ATOM 4621 C CE2 . TYR A 1 597 ? 123.426 100.491 114.824 1.00 52.23 ? 640 TYR A CE2 1 
ATOM 4622 C CZ  . TYR A 1 597 ? 123.876 99.456  115.613 1.00 53.39 ? 640 TYR A CZ  1 
ATOM 4623 O OH  . TYR A 1 597 ? 123.150 98.290  115.686 1.00 54.33 ? 640 TYR A OH  1 
ATOM 4624 N N   . SER A 1 598 ? 127.868 101.565 112.613 1.00 55.30 ? 641 SER A N   1 
ATOM 4625 C CA  . SER A 1 598 ? 127.650 100.985 111.301 1.00 53.19 ? 641 SER A CA  1 
ATOM 4626 C C   . SER A 1 598 ? 127.716 99.468  111.410 1.00 53.41 ? 641 SER A C   1 
ATOM 4627 O O   . SER A 1 598 ? 128.541 98.938  112.163 1.00 58.24 ? 641 SER A O   1 
ATOM 4628 C CB  . SER A 1 598 ? 128.700 101.486 110.298 1.00 55.02 ? 641 SER A CB  1 
ATOM 4629 O OG  . SER A 1 598 ? 128.203 101.450 108.972 1.00 54.71 ? 641 SER A OG  1 
ATOM 4630 N N   . PRO A 1 599 ? 126.878 98.744  110.674 1.00 51.35 ? 642 PRO A N   1 
ATOM 4631 C CA  . PRO A 1 599 ? 126.856 97.291  110.785 1.00 55.48 ? 642 PRO A CA  1 
ATOM 4632 C C   . PRO A 1 599 ? 127.691 96.532  109.755 1.00 55.84 ? 642 PRO A C   1 
ATOM 4633 O O   . PRO A 1 599 ? 128.139 97.058  108.731 1.00 58.17 ? 642 PRO A O   1 
ATOM 4634 C CB  . PRO A 1 599 ? 125.354 97.024  110.626 1.00 55.60 ? 642 PRO A CB  1 
ATOM 4635 C CG  . PRO A 1 599 ? 124.935 98.121  109.532 1.00 58.58 ? 642 PRO A CG  1 
ATOM 4636 C CD  . PRO A 1 599 ? 126.209 99.018  109.388 1.00 54.57 ? 642 PRO A CD  1 
ATOM 4637 N N   . THR A 1 600 ? 127.935 95.268  110.080 1.00 58.25 ? 643 THR A N   1 
ATOM 4638 C CA  . THR A 1 600 ? 128.640 94.352  109.199 1.00 58.76 ? 643 THR A CA  1 
ATOM 4639 C C   . THR A 1 600 ? 127.637 93.462  108.476 1.00 62.24 ? 643 THR A C   1 
ATOM 4640 O O   . THR A 1 600 ? 126.551 93.173  108.986 1.00 65.45 ? 643 THR A O   1 
ATOM 4641 C CB  . THR A 1 600 ? 129.649 93.497  109.975 1.00 61.92 ? 643 THR A CB  1 
ATOM 4642 O OG1 . THR A 1 600 ? 130.600 92.933  109.064 1.00 65.01 ? 643 THR A OG1 1 
ATOM 4643 C CG2 . THR A 1 600 ? 128.954 92.372  110.732 1.00 62.39 ? 643 THR A CG2 1 
ATOM 4644 N N   . GLY A 1 601 ? 128.002 93.049  107.268 1.00 60.78 ? 644 GLY A N   1 
ATOM 4645 C CA  . GLY A 1 601 ? 127.076 92.259  106.488 1.00 61.66 ? 644 GLY A CA  1 
ATOM 4646 C C   . GLY A 1 601 ? 125.935 93.116  105.964 1.00 65.59 ? 644 GLY A C   1 
ATOM 4647 O O   . GLY A 1 601 ? 125.991 94.348  105.943 1.00 66.54 ? 644 GLY A O   1 
ATOM 4648 N N   . TYR A 1 602 ? 124.879 92.432  105.531 1.00 58.12 ? 645 TYR A N   1 
ATOM 4649 C CA  . TYR A 1 602 ? 123.686 93.074  104.982 1.00 50.65 ? 645 TYR A CA  1 
ATOM 4650 C C   . TYR A 1 602 ? 122.461 92.491  105.670 1.00 52.25 ? 645 TYR A C   1 
ATOM 4651 O O   . TYR A 1 602 ? 121.809 91.581  105.142 1.00 61.00 ? 645 TYR A O   1 
ATOM 4652 C CB  . TYR A 1 602 ? 123.615 92.899  103.466 1.00 54.35 ? 645 TYR A CB  1 
ATOM 4653 C CG  . TYR A 1 602 ? 124.803 93.480  102.739 1.00 56.41 ? 645 TYR A CG  1 
ATOM 4654 C CD1 . TYR A 1 602 ? 125.953 92.731  102.538 1.00 57.40 ? 645 TYR A CD1 1 
ATOM 4655 C CD2 . TYR A 1 602 ? 124.776 94.781  102.258 1.00 59.65 ? 645 TYR A CD2 1 
ATOM 4656 C CE1 . TYR A 1 602 ? 127.040 93.259  101.876 1.00 60.71 ? 645 TYR A CE1 1 
ATOM 4657 C CE2 . TYR A 1 602 ? 125.860 95.318  101.594 1.00 61.60 ? 645 TYR A CE2 1 
ATOM 4658 C CZ  . TYR A 1 602 ? 126.990 94.551  101.406 1.00 63.90 ? 645 TYR A CZ  1 
ATOM 4659 O OH  . TYR A 1 602 ? 128.077 95.075  100.746 1.00 61.92 ? 645 TYR A OH  1 
ATOM 4660 N N   . PRO A 1 603 ? 122.122 92.990  106.855 1.00 34.49 ? 646 PRO A N   1 
ATOM 4661 C CA  . PRO A 1 603 ? 120.963 92.459  107.576 1.00 42.57 ? 646 PRO A CA  1 
ATOM 4662 C C   . PRO A 1 603 ? 119.655 92.817  106.887 1.00 47.17 ? 646 PRO A C   1 
ATOM 4663 O O   . PRO A 1 603 ? 119.572 93.746  106.081 1.00 51.57 ? 646 PRO A O   1 
ATOM 4664 C CB  . PRO A 1 603 ? 121.063 93.123  108.953 1.00 48.14 ? 646 PRO A CB  1 
ATOM 4665 C CG  . PRO A 1 603 ? 121.867 94.349  108.725 1.00 50.46 ? 646 PRO A CG  1 
ATOM 4666 C CD  . PRO A 1 603 ? 122.822 94.037  107.616 1.00 44.05 ? 646 PRO A CD  1 
ATOM 4667 N N   . ASP A 1 604 ? 118.622 92.049  107.219 1.00 51.78 ? 647 ASP A N   1 
ATOM 4668 C CA  . ASP A 1 604 ? 117.299 92.281  106.661 1.00 47.43 ? 647 ASP A CA  1 
ATOM 4669 C C   . ASP A 1 604 ? 116.714 93.588  107.181 1.00 51.41 ? 647 ASP A C   1 
ATOM 4670 O O   . ASP A 1 604 ? 117.037 94.048  108.279 1.00 56.28 ? 647 ASP A O   1 
ATOM 4671 C CB  . ASP A 1 604 ? 116.363 91.123  107.004 1.00 55.79 ? 647 ASP A CB  1 
ATOM 4672 C CG  . ASP A 1 604 ? 116.456 89.984  106.009 1.00 66.00 ? 647 ASP A CG  1 
ATOM 4673 O OD1 . ASP A 1 604 ? 117.175 90.132  104.999 1.00 70.29 ? 647 ASP A OD1 1 
ATOM 4674 O OD2 . ASP A 1 604 ? 115.808 88.941  106.237 1.00 67.27 ? 647 ASP A OD2 1 
ATOM 4675 N N   . ILE A 1 605 ? 115.839 94.184  106.376 1.00 53.90 ? 648 ILE A N   1 
ATOM 4676 C CA  . ILE A 1 605 ? 115.187 95.446  106.699 1.00 48.29 ? 648 ILE A CA  1 
ATOM 4677 C C   . ILE A 1 605 ? 113.736 95.158  107.050 1.00 48.72 ? 648 ILE A C   1 
ATOM 4678 O O   . ILE A 1 605 ? 113.017 94.519  106.273 1.00 52.56 ? 648 ILE A O   1 
ATOM 4679 C CB  . ILE A 1 605 ? 115.283 96.445  105.534 1.00 50.38 ? 648 ILE A CB  1 
ATOM 4680 C CG1 . ILE A 1 605 ? 116.729 96.898  105.338 1.00 53.47 ? 648 ILE A CG1 1 
ATOM 4681 C CG2 . ILE A 1 605 ? 114.379 97.640  105.780 1.00 54.39 ? 648 ILE A CG2 1 
ATOM 4682 C CD1 . ILE A 1 605 ? 116.934 97.757  104.116 1.00 53.02 ? 648 ILE A CD1 1 
ATOM 4683 N N   . GLU A 1 606 ? 113.308 95.626  108.219 1.00 51.50 ? 649 GLU A N   1 
ATOM 4684 C CA  . GLU A 1 606 ? 111.944 95.437  108.695 1.00 53.73 ? 649 GLU A CA  1 
ATOM 4685 C C   . GLU A 1 606 ? 111.277 96.798  108.818 1.00 58.22 ? 649 GLU A C   1 
ATOM 4686 O O   . GLU A 1 606 ? 111.788 97.682  109.514 1.00 58.86 ? 649 GLU A O   1 
ATOM 4687 C CB  . GLU A 1 606 ? 111.928 94.707  110.039 1.00 59.11 ? 649 GLU A CB  1 
ATOM 4688 C CG  . GLU A 1 606 ? 110.538 94.379  110.550 1.00 61.26 ? 649 GLU A CG  1 
ATOM 4689 C CD  . GLU A 1 606 ? 110.542 93.942  112.001 1.00 65.01 ? 649 GLU A CD  1 
ATOM 4690 O OE1 . GLU A 1 606 ? 111.609 94.027  112.645 1.00 62.13 ? 649 GLU A OE1 1 
ATOM 4691 O OE2 . GLU A 1 606 ? 109.479 93.513  112.498 1.00 65.77 ? 649 GLU A OE2 1 
ATOM 4692 N N   . LEU A 1 607 ? 110.143 96.964  108.144 1.00 49.96 ? 650 LEU A N   1 
ATOM 4693 C CA  . LEU A 1 607 ? 109.367 98.194  108.227 1.00 42.80 ? 650 LEU A CA  1 
ATOM 4694 C C   . LEU A 1 607 ? 108.258 98.012  109.254 1.00 44.16 ? 650 LEU A C   1 
ATOM 4695 O O   . LEU A 1 607 ? 107.395 97.142  109.096 1.00 52.71 ? 650 LEU A O   1 
ATOM 4696 C CB  . LEU A 1 607 ? 108.781 98.562  106.865 1.00 43.47 ? 650 LEU A CB  1 
ATOM 4697 C CG  . LEU A 1 607 ? 109.738 98.590  105.674 1.00 40.99 ? 650 LEU A CG  1 
ATOM 4698 C CD1 . LEU A 1 607 ? 108.959 98.583  104.374 1.00 42.63 ? 650 LEU A CD1 1 
ATOM 4699 C CD2 . LEU A 1 607 ? 110.645 99.801  105.745 1.00 46.13 ? 650 LEU A CD2 1 
ATOM 4700 N N   . LYS A 1 608 ? 108.282 98.828  110.302 1.00 38.36 ? 651 LYS A N   1 
ATOM 4701 C CA  . LYS A 1 608 ? 107.279 98.778  111.353 1.00 49.54 ? 651 LYS A CA  1 
ATOM 4702 C C   . LYS A 1 608 ? 106.517 100.094 111.406 1.00 48.96 ? 651 LYS A C   1 
ATOM 4703 O O   . LYS A 1 608 ? 107.013 101.144 110.990 1.00 47.92 ? 651 LYS A O   1 
ATOM 4704 C CB  . LYS A 1 608 ? 107.912 98.470  112.717 1.00 50.83 ? 651 LYS A CB  1 
ATOM 4705 C CG  . LYS A 1 608 ? 109.295 97.849  112.630 1.00 54.17 ? 651 LYS A CG  1 
ATOM 4706 C CD  . LYS A 1 608 ? 109.855 97.551  114.010 1.00 53.13 ? 651 LYS A CD  1 
ATOM 4707 C CE  . LYS A 1 608 ? 111.328 97.187  113.939 1.00 49.94 ? 651 LYS A CE  1 
ATOM 4708 N NZ  . LYS A 1 608 ? 111.993 97.304  115.265 1.00 50.41 ? 651 LYS A NZ  1 
ATOM 4709 N N   . GLY A 1 609 ? 105.296 100.020 111.922 1.00 46.42 ? 652 GLY A N   1 
ATOM 4710 C CA  . GLY A 1 609 ? 104.392 101.147 111.923 1.00 43.09 ? 652 GLY A CA  1 
ATOM 4711 C C   . GLY A 1 609 ? 103.390 101.165 110.793 1.00 47.78 ? 652 GLY A C   1 
ATOM 4712 O O   . GLY A 1 609 ? 102.706 102.179 110.613 1.00 55.78 ? 652 GLY A O   1 
ATOM 4713 N N   . LEU A 1 610 ? 103.281 100.084 110.030 1.00 44.19 ? 653 LEU A N   1 
ATOM 4714 C CA  . LEU A 1 610 ? 102.358 99.989  108.912 1.00 39.55 ? 653 LEU A CA  1 
ATOM 4715 C C   . LEU A 1 610 ? 101.122 99.191  109.308 1.00 42.71 ? 653 LEU A C   1 
ATOM 4716 O O   . LEU A 1 610 ? 101.131 98.423  110.273 1.00 53.86 ? 653 LEU A O   1 
ATOM 4717 C CB  . LEU A 1 610 ? 103.039 99.342  107.705 1.00 36.75 ? 653 LEU A CB  1 
ATOM 4718 C CG  . LEU A 1 610 ? 104.184 100.141 107.085 1.00 41.04 ? 653 LEU A CG  1 
ATOM 4719 C CD1 . LEU A 1 610 ? 104.813 99.377  105.934 1.00 44.58 ? 653 LEU A CD1 1 
ATOM 4720 C CD2 . LEU A 1 610 ? 103.695 101.503 106.623 1.00 47.17 ? 653 LEU A CD2 1 
ATOM 4721 N N   . ASP A 1 611 ? 100.053 99.383  108.548 1.00 36.70 ? 654 ASP A N   1 
ATOM 4722 C CA  . ASP A 1 611 ? 98.804  98.690  108.836 1.00 44.63 ? 654 ASP A CA  1 
ATOM 4723 C C   . ASP A 1 611 ? 98.944  97.208  108.506 1.00 52.16 ? 654 ASP A C   1 
ATOM 4724 O O   . ASP A 1 611 ? 99.335  96.862  107.385 1.00 57.29 ? 654 ASP A O   1 
ATOM 4725 C CB  . ASP A 1 611 ? 97.655  99.305  108.043 1.00 55.22 ? 654 ASP A CB  1 
ATOM 4726 C CG  . ASP A 1 611 ? 96.385  99.430  108.860 1.00 58.86 ? 654 ASP A CG  1 
ATOM 4727 O OD1 . ASP A 1 611 ? 96.476  99.436  110.106 1.00 60.25 ? 654 ASP A OD1 1 
ATOM 4728 O OD2 . ASP A 1 611 ? 95.295  99.524  108.258 1.00 59.82 ? 654 ASP A OD2 1 
ATOM 4729 N N   . PRO A 1 612 ? 98.649  96.309  109.447 1.00 51.20 ? 655 PRO A N   1 
ATOM 4730 C CA  . PRO A 1 612 ? 98.811  94.872  109.166 1.00 49.72 ? 655 PRO A CA  1 
ATOM 4731 C C   . PRO A 1 612 ? 97.925  94.358  108.046 1.00 56.15 ? 655 PRO A C   1 
ATOM 4732 O O   . PRO A 1 612 ? 98.322  93.426  107.336 1.00 59.24 ? 655 PRO A O   1 
ATOM 4733 C CB  . PRO A 1 612 ? 98.460  94.211  110.507 1.00 52.71 ? 655 PRO A CB  1 
ATOM 4734 C CG  . PRO A 1 612 ? 98.587  95.294  111.528 1.00 57.65 ? 655 PRO A CG  1 
ATOM 4735 C CD  . PRO A 1 612 ? 98.219  96.561  110.831 1.00 55.83 ? 655 PRO A CD  1 
ATOM 4736 N N   . ASN A 1 613 ? 96.735  94.930  107.863 1.00 55.38 ? 656 ASN A N   1 
ATOM 4737 C CA  . ASN A 1 613 ? 95.768  94.434  106.892 1.00 53.07 ? 656 ASN A CA  1 
ATOM 4738 C C   . ASN A 1 613 ? 95.815  95.200  105.575 1.00 57.16 ? 656 ASN A C   1 
ATOM 4739 O O   . ASN A 1 613 ? 94.789  95.337  104.901 1.00 60.58 ? 656 ASN A O   1 
ATOM 4740 C CB  . ASN A 1 613 ? 94.358  94.479  107.480 1.00 57.27 ? 656 ASN A CB  1 
ATOM 4741 C CG  . ASN A 1 613 ? 94.350  94.317  108.985 1.00 60.13 ? 656 ASN A CG  1 
ATOM 4742 O OD1 . ASN A 1 613 ? 94.365  95.298  109.728 1.00 58.17 ? 656 ASN A OD1 1 
ATOM 4743 N ND2 . ASN A 1 613 ? 94.326  93.072  109.445 1.00 62.37 ? 656 ASN A ND2 1 
ATOM 4744 N N   . LYS A 1 614 ? 96.985  95.702  105.193 1.00 50.76 ? 657 LYS A N   1 
ATOM 4745 C CA  . LYS A 1 614 ? 97.150  96.427  103.943 1.00 46.14 ? 657 LYS A CA  1 
ATOM 4746 C C   . LYS A 1 614 ? 98.356  95.886  103.193 1.00 47.63 ? 657 LYS A C   1 
ATOM 4747 O O   . LYS A 1 614 ? 99.314  95.393  103.794 1.00 55.23 ? 657 LYS A O   1 
ATOM 4748 C CB  . LYS A 1 614 ? 97.319  97.934  104.180 1.00 50.35 ? 657 LYS A CB  1 
ATOM 4749 C CG  . LYS A 1 614 ? 96.034  98.650  104.559 1.00 52.65 ? 657 LYS A CG  1 
ATOM 4750 C CD  . LYS A 1 614 ? 96.279  100.129 104.803 1.00 47.99 ? 657 LYS A CD  1 
ATOM 4751 C CE  . LYS A 1 614 ? 94.994  100.845 105.180 1.00 52.47 ? 657 LYS A CE  1 
ATOM 4752 N NZ  . LYS A 1 614 ? 95.229  102.283 105.486 1.00 54.30 ? 657 LYS A NZ  1 
ATOM 4753 N N   . MET A 1 615 ? 98.298  95.982  101.869 1.00 43.73 ? 658 MET A N   1 
ATOM 4754 C CA  . MET A 1 615 ? 99.380  95.553  100.994 1.00 45.07 ? 658 MET A CA  1 
ATOM 4755 C C   . MET A 1 615 ? 100.104 96.783  100.471 1.00 50.38 ? 658 MET A C   1 
ATOM 4756 O O   . MET A 1 615 ? 99.469  97.710  99.956  1.00 54.53 ? 658 MET A O   1 
ATOM 4757 C CB  . MET A 1 615 ? 98.846  94.709  99.837  1.00 46.99 ? 658 MET A CB  1 
ATOM 4758 C CG  . MET A 1 615 ? 99.510  93.352  99.702  1.00 46.64 ? 658 MET A CG  1 
ATOM 4759 S SD  . MET A 1 615 ? 99.315  92.652  98.056  1.00 61.28 ? 658 MET A SD  1 
ATOM 4760 C CE  . MET A 1 615 ? 97.530  92.646  97.913  1.00 54.21 ? 658 MET A CE  1 
ATOM 4761 N N   . TYR A 1 616 ? 101.426 96.792  100.604 1.00 44.35 ? 659 TYR A N   1 
ATOM 4762 C CA  . TYR A 1 616 ? 102.232 97.960  100.296 1.00 41.91 ? 659 TYR A CA  1 
ATOM 4763 C C   . TYR A 1 616 ? 103.226 97.654  99.186  1.00 44.42 ? 659 TYR A C   1 
ATOM 4764 O O   . TYR A 1 616 ? 103.723 96.531  99.062  1.00 48.59 ? 659 TYR A O   1 
ATOM 4765 C CB  . TYR A 1 616 ? 102.989 98.452  101.534 1.00 37.52 ? 659 TYR A CB  1 
ATOM 4766 C CG  . TYR A 1 616 ? 102.096 98.941  102.646 1.00 38.19 ? 659 TYR A CG  1 
ATOM 4767 C CD1 . TYR A 1 616 ? 101.680 100.261 102.694 1.00 46.26 ? 659 TYR A CD1 1 
ATOM 4768 C CD2 . TYR A 1 616 ? 101.674 98.084  103.650 1.00 40.56 ? 659 TYR A CD2 1 
ATOM 4769 C CE1 . TYR A 1 616 ? 100.865 100.715 103.708 1.00 49.52 ? 659 TYR A CE1 1 
ATOM 4770 C CE2 . TYR A 1 616 ? 100.859 98.529  104.669 1.00 41.76 ? 659 TYR A CE2 1 
ATOM 4771 C CZ  . TYR A 1 616 ? 100.458 99.846  104.692 1.00 46.80 ? 659 TYR A CZ  1 
ATOM 4772 O OH  . TYR A 1 616 ? 99.646  100.298 105.704 1.00 51.12 ? 659 TYR A OH  1 
ATOM 4773 N N   . ARG A 1 617 ? 103.506 98.672  98.379  1.00 37.36 ? 660 ARG A N   1 
ATOM 4774 C CA  . ARG A 1 617 ? 104.545 98.627  97.360  1.00 31.61 ? 660 ARG A CA  1 
ATOM 4775 C C   . ARG A 1 617 ? 105.626 99.625  97.751  1.00 41.59 ? 660 ARG A C   1 
ATOM 4776 O O   . ARG A 1 617 ? 105.341 100.815 97.920  1.00 51.04 ? 660 ARG A O   1 
ATOM 4777 C CB  . ARG A 1 617 ? 103.972 98.952  95.982  1.00 38.65 ? 660 ARG A CB  1 
ATOM 4778 C CG  . ARG A 1 617 ? 104.758 98.369  94.826  1.00 42.97 ? 660 ARG A CG  1 
ATOM 4779 C CD  . ARG A 1 617 ? 105.385 99.465  93.985  1.00 42.27 ? 660 ARG A CD  1 
ATOM 4780 N NE  . ARG A 1 617 ? 104.405 100.450 93.546  1.00 41.22 ? 660 ARG A NE  1 
ATOM 4781 C CZ  . ARG A 1 617 ? 103.497 100.240 92.603  1.00 43.99 ? 660 ARG A CZ  1 
ATOM 4782 N NH1 . ARG A 1 617 ? 103.419 99.085  91.963  1.00 46.48 ? 660 ARG A NH1 1 
ATOM 4783 N NH2 . ARG A 1 617 ? 102.647 101.214 92.292  1.00 42.21 ? 660 ARG A NH2 1 
ATOM 4784 N N   . ILE A 1 618 ? 106.856 99.146  97.893  1.00 39.01 ? 661 ILE A N   1 
ATOM 4785 C CA  . ILE A 1 618 ? 107.961 99.953  98.396  1.00 30.96 ? 661 ILE A CA  1 
ATOM 4786 C C   . ILE A 1 618 ? 108.756 100.454 97.199  1.00 37.55 ? 661 ILE A C   1 
ATOM 4787 O O   . ILE A 1 618 ? 109.325 99.661  96.442  1.00 44.76 ? 661 ILE A O   1 
ATOM 4788 C CB  . ILE A 1 618 ? 108.846 99.158  99.363  1.00 30.78 ? 661 ILE A CB  1 
ATOM 4789 C CG1 . ILE A 1 618 ? 107.981 98.362  100.339 1.00 39.76 ? 661 ILE A CG1 1 
ATOM 4790 C CG2 . ILE A 1 618 ? 109.767 100.091 100.123 1.00 37.13 ? 661 ILE A CG2 1 
ATOM 4791 C CD1 . ILE A 1 618 ? 107.115 99.222  101.228 1.00 43.93 ? 661 ILE A CD1 1 
ATOM 4792 N N   . VAL A 1 619 ? 108.799 101.773 97.028  1.00 44.43 ? 662 VAL A N   1 
ATOM 4793 C CA  . VAL A 1 619 ? 109.461 102.400 95.892  1.00 45.75 ? 662 VAL A CA  1 
ATOM 4794 C C   . VAL A 1 619 ? 110.369 103.510 96.400  1.00 45.67 ? 662 VAL A C   1 
ATOM 4795 O O   . VAL A 1 619 ? 109.939 104.366 97.180  1.00 52.35 ? 662 VAL A O   1 
ATOM 4796 C CB  . VAL A 1 619 ? 108.443 102.951 94.874  1.00 43.38 ? 662 VAL A CB  1 
ATOM 4797 C CG1 . VAL A 1 619 ? 107.319 103.685 95.584  1.00 48.41 ? 662 VAL A CG1 1 
ATOM 4798 C CG2 . VAL A 1 619 ? 109.129 103.863 93.870  1.00 50.16 ? 662 VAL A CG2 1 
ATOM 4799 N N   . ASP A 1 620 ? 111.627 103.485 95.968  1.00 45.85 ? 663 ASP A N   1 
ATOM 4800 C CA  . ASP A 1 620 ? 112.542 104.588 96.215  1.00 47.04 ? 663 ASP A CA  1 
ATOM 4801 C C   . ASP A 1 620 ? 112.166 105.768 95.329  1.00 55.82 ? 663 ASP A C   1 
ATOM 4802 O O   . ASP A 1 620 ? 111.904 105.604 94.136  1.00 56.99 ? 663 ASP A O   1 
ATOM 4803 C CB  . ASP A 1 620 ? 113.982 104.152 95.939  1.00 47.90 ? 663 ASP A CB  1 
ATOM 4804 C CG  . ASP A 1 620 ? 115.002 105.236 96.254  1.00 59.06 ? 663 ASP A CG  1 
ATOM 4805 O OD1 . ASP A 1 620 ? 114.613 106.320 96.735  1.00 62.84 ? 663 ASP A OD1 1 
ATOM 4806 O OD2 . ASP A 1 620 ? 116.205 104.998 96.016  1.00 59.92 ? 663 ASP A OD2 1 
ATOM 4807 N N   . TYR A 1 621 ? 112.135 106.963 95.920  1.00 52.19 ? 664 TYR A N   1 
ATOM 4808 C CA  . TYR A 1 621 ? 111.798 108.158 95.159  1.00 45.56 ? 664 TYR A CA  1 
ATOM 4809 C C   . TYR A 1 621 ? 113.017 108.896 94.626  1.00 48.07 ? 664 TYR A C   1 
ATOM 4810 O O   . TYR A 1 621 ? 112.865 109.748 93.744  1.00 50.52 ? 664 TYR A O   1 
ATOM 4811 C CB  . TYR A 1 621 ? 110.959 109.126 96.004  1.00 47.19 ? 664 TYR A CB  1 
ATOM 4812 C CG  . TYR A 1 621 ? 111.405 109.290 97.438  1.00 45.73 ? 664 TYR A CG  1 
ATOM 4813 C CD1 . TYR A 1 621 ? 110.969 108.420 98.427  1.00 49.32 ? 664 TYR A CD1 1 
ATOM 4814 C CD2 . TYR A 1 621 ? 112.245 110.331 97.807  1.00 49.69 ? 664 TYR A CD2 1 
ATOM 4815 C CE1 . TYR A 1 621 ? 111.369 108.573 99.740  1.00 51.06 ? 664 TYR A CE1 1 
ATOM 4816 C CE2 . TYR A 1 621 ? 112.649 110.493 99.116  1.00 49.84 ? 664 TYR A CE2 1 
ATOM 4817 C CZ  . TYR A 1 621 ? 112.208 109.612 100.079 1.00 51.52 ? 664 TYR A CZ  1 
ATOM 4818 O OH  . TYR A 1 621 ? 112.607 109.767 101.386 1.00 50.82 ? 664 TYR A OH  1 
ATOM 4819 N N   . VAL A 1 622 ? 114.212 108.597 95.135  1.00 46.08 ? 665 VAL A N   1 
ATOM 4820 C CA  . VAL A 1 622 ? 115.416 109.223 94.602  1.00 47.83 ? 665 VAL A CA  1 
ATOM 4821 C C   . VAL A 1 622 ? 115.708 108.716 93.196  1.00 57.83 ? 665 VAL A C   1 
ATOM 4822 O O   . VAL A 1 622 ? 116.159 109.474 92.329  1.00 63.34 ? 665 VAL A O   1 
ATOM 4823 C CB  . VAL A 1 622 ? 116.606 108.990 95.549  1.00 53.24 ? 665 VAL A CB  1 
ATOM 4824 C CG1 . VAL A 1 622 ? 117.727 109.964 95.236  1.00 57.60 ? 665 VAL A CG1 1 
ATOM 4825 C CG2 . VAL A 1 622 ? 116.165 109.136 96.995  1.00 55.13 ? 665 VAL A CG2 1 
ATOM 4826 N N   . ASN A 1 623 ? 115.457 107.431 92.943  1.00 60.96 ? 666 ASN A N   1 
ATOM 4827 C CA  . ASN A 1 623 ? 115.755 106.824 91.654  1.00 60.64 ? 666 ASN A CA  1 
ATOM 4828 C C   . ASN A 1 623 ? 114.534 106.250 90.948  1.00 61.30 ? 666 ASN A C   1 
ATOM 4829 O O   . ASN A 1 623 ? 114.664 105.784 89.810  1.00 63.51 ? 666 ASN A O   1 
ATOM 4830 C CB  . ASN A 1 623 ? 116.807 105.720 91.820  1.00 60.73 ? 666 ASN A CB  1 
ATOM 4831 C CG  . ASN A 1 623 ? 117.903 106.102 92.792  1.00 64.65 ? 666 ASN A CG  1 
ATOM 4832 O OD1 . ASN A 1 623 ? 118.151 105.400 93.772  1.00 65.98 ? 666 ASN A OD1 1 
ATOM 4833 N ND2 . ASN A 1 623 ? 118.567 107.220 92.525  1.00 65.06 ? 666 ASN A ND2 1 
ATOM 4834 N N   . ASP A 1 624 ? 113.361 106.266 91.583  1.00 58.02 ? 667 ASP A N   1 
ATOM 4835 C CA  . ASP A 1 624 ? 112.123 105.744 91.002  1.00 58.26 ? 667 ASP A CA  1 
ATOM 4836 C C   . ASP A 1 624 ? 112.269 104.267 90.625  1.00 63.16 ? 667 ASP A C   1 
ATOM 4837 O O   . ASP A 1 624 ? 112.144 103.873 89.464  1.00 62.76 ? 667 ASP A O   1 
ATOM 4838 C CB  . ASP A 1 624 ? 111.684 106.584 89.798  1.00 59.54 ? 667 ASP A CB  1 
ATOM 4839 C CG  . ASP A 1 624 ? 110.179 106.612 89.625  1.00 65.39 ? 667 ASP A CG  1 
ATOM 4840 O OD1 . ASP A 1 624 ? 109.475 106.979 90.589  1.00 64.43 ? 667 ASP A OD1 1 
ATOM 4841 O OD2 . ASP A 1 624 ? 109.699 106.267 88.525  1.00 69.02 ? 667 ASP A OD2 1 
ATOM 4842 N N   . ARG A 1 625 ? 112.541 103.450 91.641  1.00 55.31 ? 668 ARG A N   1 
ATOM 4843 C CA  . ARG A 1 625 ? 112.682 102.011 91.478  1.00 43.63 ? 668 ARG A CA  1 
ATOM 4844 C C   . ARG A 1 625 ? 111.879 101.295 92.553  1.00 41.59 ? 668 ARG A C   1 
ATOM 4845 O O   . ARG A 1 625 ? 111.772 101.768 93.687  1.00 54.24 ? 668 ARG A O   1 
ATOM 4846 C CB  . ARG A 1 625 ? 114.150 101.573 91.554  1.00 52.09 ? 668 ARG A CB  1 
ATOM 4847 C CG  . ARG A 1 625 ? 115.046 102.199 90.498  1.00 55.97 ? 668 ARG A CG  1 
ATOM 4848 C CD  . ARG A 1 625 ? 116.451 101.625 90.561  1.00 54.16 ? 668 ARG A CD  1 
ATOM 4849 N NE  . ARG A 1 625 ? 117.201 102.137 91.702  1.00 61.94 ? 668 ARG A NE  1 
ATOM 4850 C CZ  . ARG A 1 625 ? 117.496 101.427 92.782  1.00 62.71 ? 668 ARG A CZ  1 
ATOM 4851 N NH1 . ARG A 1 625 ? 117.119 100.165 92.905  1.00 58.67 ? 668 ARG A NH1 1 
ATOM 4852 N NH2 . ARG A 1 625 ? 118.188 101.999 93.764  1.00 58.88 ? 668 ARG A NH2 1 
ATOM 4853 N N   . VAL A 1 626 ? 111.319 100.145 92.187  1.00 31.35 ? 669 VAL A N   1 
ATOM 4854 C CA  . VAL A 1 626 ? 110.527 99.334  93.106  1.00 34.98 ? 669 VAL A CA  1 
ATOM 4855 C C   . VAL A 1 626 ? 111.466 98.310  93.735  1.00 44.31 ? 669 VAL A C   1 
ATOM 4856 O O   . VAL A 1 626 ? 111.826 97.310  93.111  1.00 48.86 ? 669 VAL A O   1 
ATOM 4857 C CB  . VAL A 1 626 ? 109.349 98.665  92.398  1.00 39.22 ? 669 VAL A CB  1 
ATOM 4858 C CG1 . VAL A 1 626 ? 108.563 97.811  93.376  1.00 42.57 ? 669 VAL A CG1 1 
ATOM 4859 C CG2 . VAL A 1 626 ? 108.453 99.713  91.761  1.00 43.84 ? 669 VAL A CG2 1 
ATOM 4860 N N   . VAL A 1 627 ? 111.872 98.566  94.980  1.00 34.44 ? 670 VAL A N   1 
ATOM 4861 C CA  . VAL A 1 627 ? 112.758 97.640  95.677  1.00 29.43 ? 670 VAL A CA  1 
ATOM 4862 C C   . VAL A 1 627 ? 112.018 96.362  96.056  1.00 33.85 ? 670 VAL A C   1 
ATOM 4863 O O   . VAL A 1 627 ? 112.573 95.260  95.973  1.00 41.69 ? 670 VAL A O   1 
ATOM 4864 C CB  . VAL A 1 627 ? 113.387 98.324  96.905  1.00 37.79 ? 670 VAL A CB  1 
ATOM 4865 C CG1 . VAL A 1 627 ? 114.426 99.339  96.464  1.00 41.95 ? 670 VAL A CG1 1 
ATOM 4866 C CG2 . VAL A 1 627 ? 112.321 98.996  97.749  1.00 43.07 ? 670 VAL A CG2 1 
ATOM 4867 N N   . ALA A 1 628 ? 110.762 96.483  96.480  1.00 34.54 ? 671 ALA A N   1 
ATOM 4868 C CA  . ALA A 1 628 ? 109.975 95.329  96.886  1.00 38.59 ? 671 ALA A CA  1 
ATOM 4869 C C   . ALA A 1 628 ? 108.506 95.611  96.613  1.00 40.07 ? 671 ALA A C   1 
ATOM 4870 O O   . ALA A 1 628 ? 108.091 96.764  96.471  1.00 52.44 ? 671 ALA A O   1 
ATOM 4871 C CB  . ALA A 1 628 ? 110.193 94.988  98.364  1.00 45.88 ? 671 ALA A CB  1 
ATOM 4872 N N   . THR A 1 629 ? 107.719 94.541  96.546  1.00 36.04 ? 672 THR A N   1 
ATOM 4873 C CA  . THR A 1 629 ? 106.308 94.657  96.214  1.00 32.28 ? 672 THR A CA  1 
ATOM 4874 C C   . THR A 1 629 ? 105.542 93.506  96.846  1.00 32.74 ? 672 THR A C   1 
ATOM 4875 O O   . THR A 1 629 ? 106.125 92.503  97.267  1.00 46.91 ? 672 THR A O   1 
ATOM 4876 C CB  . THR A 1 629 ? 106.082 94.669  94.699  1.00 45.67 ? 672 THR A CB  1 
ATOM 4877 O OG1 . THR A 1 629 ? 104.712 94.360  94.418  1.00 48.83 ? 672 THR A OG1 1 
ATOM 4878 C CG2 . THR A 1 629 ? 106.977 93.646  94.020  1.00 43.89 ? 672 THR A CG2 1 
ATOM 4879 N N   . ASN A 1 630 ? 104.219 93.668  96.899  1.00 32.22 ? 673 ASN A N   1 
ATOM 4880 C CA  . ASN A 1 630 ? 103.319 92.682  97.496  1.00 33.01 ? 673 ASN A CA  1 
ATOM 4881 C C   . ASN A 1 630 ? 103.727 92.365  98.932  1.00 43.91 ? 673 ASN A C   1 
ATOM 4882 O O   . ASN A 1 630 ? 103.689 91.214  99.371  1.00 53.28 ? 673 ASN A O   1 
ATOM 4883 C CB  . ASN A 1 630 ? 103.255 91.408  96.652  1.00 39.12 ? 673 ASN A CB  1 
ATOM 4884 C CG  . ASN A 1 630 ? 102.981 91.693  95.191  1.00 44.74 ? 673 ASN A CG  1 
ATOM 4885 O OD1 . ASN A 1 630 ? 102.792 92.843  94.797  1.00 53.08 ? 673 ASN A OD1 1 
ATOM 4886 N ND2 . ASN A 1 630 ? 102.957 90.645  94.378  1.00 41.88 ? 673 ASN A ND2 1 
ATOM 4887 N N   . LEU A 1 631 ? 104.119 93.399  99.668  1.00 41.08 ? 674 LEU A N   1 
ATOM 4888 C CA  . LEU A 1 631 ? 104.628 93.256  101.026 1.00 37.82 ? 674 LEU A CA  1 
ATOM 4889 C C   . LEU A 1 631 ? 103.508 93.581  102.005 1.00 42.44 ? 674 LEU A C   1 
ATOM 4890 O O   . LEU A 1 631 ? 103.103 94.740  102.133 1.00 50.80 ? 674 LEU A O   1 
ATOM 4891 C CB  . LEU A 1 631 ? 105.831 94.170  101.246 1.00 45.21 ? 674 LEU A CB  1 
ATOM 4892 C CG  . LEU A 1 631 ? 107.027 93.580  101.989 1.00 42.65 ? 674 LEU A CG  1 
ATOM 4893 C CD1 . LEU A 1 631 ? 107.458 92.271  101.351 1.00 45.80 ? 674 LEU A CD1 1 
ATOM 4894 C CD2 . LEU A 1 631 ? 108.173 94.573  102.001 1.00 39.24 ? 674 LEU A CD2 1 
ATOM 4895 N N   . MET A 1 632 ? 103.006 92.558  102.689 1.00 40.60 ? 675 MET A N   1 
ATOM 4896 C CA  . MET A 1 632 ? 102.021 92.778  103.734 1.00 38.46 ? 675 MET A CA  1 
ATOM 4897 C C   . MET A 1 632 ? 102.654 93.517  104.907 1.00 41.32 ? 675 MET A C   1 
ATOM 4898 O O   . MET A 1 632 ? 103.849 93.387  105.182 1.00 49.65 ? 675 MET A O   1 
ATOM 4899 C CB  . MET A 1 632 ? 101.428 91.450  104.198 1.00 41.76 ? 675 MET A CB  1 
ATOM 4900 C CG  . MET A 1 632 ? 100.286 90.947  103.334 1.00 44.62 ? 675 MET A CG  1 
ATOM 4901 S SD  . MET A 1 632 ? 98.728  91.778  103.696 1.00 66.81 ? 675 MET A SD  1 
ATOM 4902 C CE  . MET A 1 632 ? 97.614  90.898  102.604 1.00 49.79 ? 675 MET A CE  1 
ATOM 4903 N N   . GLY A 1 633 ? 101.833 94.306  105.600 1.00 40.88 ? 676 GLY A N   1 
ATOM 4904 C CA  . GLY A 1 633 ? 102.339 95.169  106.652 1.00 44.09 ? 676 GLY A CA  1 
ATOM 4905 C C   . GLY A 1 633 ? 102.878 94.437  107.861 1.00 45.07 ? 676 GLY A C   1 
ATOM 4906 O O   . GLY A 1 633 ? 103.695 95.001  108.597 1.00 50.07 ? 676 GLY A O   1 
ATOM 4907 N N   . ASP A 1 634 ? 102.446 93.196  108.087 1.00 49.96 ? 677 ASP A N   1 
ATOM 4908 C CA  . ASP A 1 634 ? 102.909 92.458  109.257 1.00 49.96 ? 677 ASP A CA  1 
ATOM 4909 C C   . ASP A 1 634 ? 104.354 92.006  109.084 1.00 54.50 ? 677 ASP A C   1 
ATOM 4910 O O   . ASP A 1 634 ? 105.231 92.376  109.872 1.00 56.17 ? 677 ASP A O   1 
ATOM 4911 C CB  . ASP A 1 634 ? 101.991 91.264  109.526 1.00 54.79 ? 677 ASP A CB  1 
ATOM 4912 C CG  . ASP A 1 634 ? 101.459 90.640  108.255 1.00 63.13 ? 677 ASP A CG  1 
ATOM 4913 O OD1 . ASP A 1 634 ? 102.154 90.716  107.220 1.00 65.14 ? 677 ASP A OD1 1 
ATOM 4914 O OD2 . ASP A 1 634 ? 100.348 90.072  108.289 1.00 64.19 ? 677 ASP A OD2 1 
ATOM 4915 N N   . ASN A 1 635 ? 104.620 91.193  108.061 1.00 52.38 ? 678 ASN A N   1 
ATOM 4916 C CA  . ASN A 1 635 ? 105.977 90.725  107.807 1.00 50.53 ? 678 ASN A CA  1 
ATOM 4917 C C   . ASN A 1 635 ? 106.897 91.890  107.466 1.00 53.06 ? 678 ASN A C   1 
ATOM 4918 O O   . ASN A 1 635 ? 107.793 92.226  108.247 1.00 62.14 ? 678 ASN A O   1 
ATOM 4919 C CB  . ASN A 1 635 ? 105.984 89.695  106.676 1.00 49.86 ? 678 ASN A CB  1 
ATOM 4920 C CG  . ASN A 1 635 ? 105.431 88.354  107.107 1.00 58.55 ? 678 ASN A CG  1 
ATOM 4921 O OD1 . ASN A 1 635 ? 105.468 88.005  108.287 1.00 56.19 ? 678 ASN A OD1 1 
ATOM 4922 N ND2 . ASN A 1 635 ? 104.913 87.592  106.151 1.00 58.54 ? 678 ASN A ND2 1 
ATOM 4923 N N   . ALA A 1 636 ? 106.659 92.522  106.316 1.00 37.78 ? 679 ALA A N   1 
ATOM 4924 C CA  . ALA A 1 636 ? 107.368 93.735  105.905 1.00 36.66 ? 679 ALA A CA  1 
ATOM 4925 C C   . ALA A 1 636 ? 108.884 93.574  105.998 1.00 45.47 ? 679 ALA A C   1 
ATOM 4926 O O   . ALA A 1 636 ? 109.594 94.455  106.485 1.00 50.25 ? 679 ALA A O   1 
ATOM 4927 C CB  . ALA A 1 636 ? 106.902 94.940  106.722 1.00 46.40 ? 679 ALA A CB  1 
ATOM 4928 N N   . VAL A 1 637 ? 109.388 92.437  105.527 1.00 52.42 ? 680 VAL A N   1 
ATOM 4929 C CA  . VAL A 1 637 ? 110.819 92.150  105.522 1.00 45.67 ? 680 VAL A CA  1 
ATOM 4930 C C   . VAL A 1 637 ? 111.250 91.894  104.086 1.00 42.58 ? 680 VAL A C   1 
ATOM 4931 O O   . VAL A 1 637 ? 110.689 91.023  103.409 1.00 50.63 ? 680 VAL A O   1 
ATOM 4932 C CB  . VAL A 1 637 ? 111.170 90.952  106.418 1.00 41.36 ? 680 VAL A CB  1 
ATOM 4933 C CG1 . VAL A 1 637 ? 112.646 90.620  106.296 1.00 43.35 ? 680 VAL A CG1 1 
ATOM 4934 C CG2 . VAL A 1 637 ? 110.811 91.246  107.862 1.00 44.93 ? 680 VAL A CG2 1 
ATOM 4935 N N   . PHE A 1 638 ? 112.242 92.650  103.623 1.00 32.88 ? 681 PHE A N   1 
ATOM 4936 C CA  . PHE A 1 638 ? 112.829 92.442  102.310 1.00 34.34 ? 681 PHE A CA  1 
ATOM 4937 C C   . PHE A 1 638 ? 114.335 92.625  102.408 1.00 45.19 ? 681 PHE A C   1 
ATOM 4938 O O   . PHE A 1 638 ? 114.829 93.387  103.242 1.00 50.68 ? 681 PHE A O   1 
ATOM 4939 C CB  . PHE A 1 638 ? 112.237 93.396  101.262 1.00 43.88 ? 681 PHE A CB  1 
ATOM 4940 C CG  . PHE A 1 638 ? 112.602 94.838  101.472 1.00 49.05 ? 681 PHE A CG  1 
ATOM 4941 C CD1 . PHE A 1 638 ? 111.871 95.630  102.339 1.00 49.49 ? 681 PHE A CD1 1 
ATOM 4942 C CD2 . PHE A 1 638 ? 113.663 95.407  100.790 1.00 43.78 ? 681 PHE A CD2 1 
ATOM 4943 C CE1 . PHE A 1 638 ? 112.199 96.955  102.531 1.00 50.45 ? 681 PHE A CE1 1 
ATOM 4944 C CE2 . PHE A 1 638 ? 113.994 96.732  100.978 1.00 44.14 ? 681 PHE A CE2 1 
ATOM 4945 C CZ  . PHE A 1 638 ? 113.261 97.506  101.850 1.00 49.89 ? 681 PHE A CZ  1 
ATOM 4946 N N   . ASN A 1 639 ? 115.060 91.918  101.548 1.00 53.25 ? 682 ASN A N   1 
ATOM 4947 C CA  . ASN A 1 639 ? 116.516 91.932  101.546 1.00 49.38 ? 682 ASN A CA  1 
ATOM 4948 C C   . ASN A 1 639 ? 117.020 92.748  100.365 1.00 51.86 ? 682 ASN A C   1 
ATOM 4949 O O   . ASN A 1 639 ? 116.623 92.504  99.221  1.00 60.27 ? 682 ASN A O   1 
ATOM 4950 C CB  . ASN A 1 639 ? 117.078 90.511  101.484 1.00 51.59 ? 682 ASN A CB  1 
ATOM 4951 C CG  . ASN A 1 639 ? 118.433 90.392  102.150 1.00 56.87 ? 682 ASN A CG  1 
ATOM 4952 O OD1 . ASN A 1 639 ? 118.637 89.547  103.021 1.00 57.46 ? 682 ASN A OD1 1 
ATOM 4953 N ND2 . ASN A 1 639 ? 119.369 91.240  101.742 1.00 56.03 ? 682 ASN A ND2 1 
ATOM 4954 N N   . THR A 1 640 ? 117.892 93.712  100.646 1.00 50.35 ? 683 THR A N   1 
ATOM 4955 C CA  . THR A 1 640 ? 118.483 94.540  99.608  1.00 51.27 ? 683 THR A CA  1 
ATOM 4956 C C   . THR A 1 640 ? 119.864 94.982  100.063 1.00 53.76 ? 683 THR A C   1 
ATOM 4957 O O   . THR A 1 640 ? 120.173 94.995  101.257 1.00 57.53 ? 683 THR A O   1 
ATOM 4958 C CB  . THR A 1 640 ? 117.609 95.758  99.284  1.00 58.36 ? 683 THR A CB  1 
ATOM 4959 O OG1 . THR A 1 640 ? 118.153 96.452  98.155  1.00 61.13 ? 683 THR A OG1 1 
ATOM 4960 C CG2 . THR A 1 640 ? 117.548 96.705  100.473 1.00 60.95 ? 683 THR A CG2 1 
ATOM 4961 N N   . ARG A 1 641 ? 120.698 95.339  99.091  1.00 62.31 ? 684 ARG A N   1 
ATOM 4962 C CA  . ARG A 1 641 ? 122.068 95.759  99.342  1.00 62.67 ? 684 ARG A CA  1 
ATOM 4963 C C   . ARG A 1 641 ? 122.268 97.170  98.811  1.00 63.84 ? 684 ARG A C   1 
ATOM 4964 O O   . ARG A 1 641 ? 121.947 97.453  97.652  1.00 65.70 ? 684 ARG A O   1 
ATOM 4965 C CB  . ARG A 1 641 ? 123.065 94.798  98.689  1.00 63.19 ? 684 ARG A CB  1 
ATOM 4966 C CG  . ARG A 1 641 ? 122.925 93.356  99.151  1.00 65.43 ? 684 ARG A CG  1 
ATOM 4967 C CD  . ARG A 1 641 ? 123.611 92.396  98.193  1.00 67.17 ? 684 ARG A CD  1 
ATOM 4968 N NE  . ARG A 1 641 ? 125.050 92.621  98.129  1.00 70.46 ? 684 ARG A NE  1 
ATOM 4969 C CZ  . ARG A 1 641 ? 125.943 91.968  98.860  1.00 70.27 ? 684 ARG A CZ  1 
ATOM 4970 N NH1 . ARG A 1 641 ? 125.579 91.038  99.727  1.00 69.11 ? 684 ARG A NH1 1 
ATOM 4971 N NH2 . ARG A 1 641 ? 127.233 92.256  98.718  1.00 66.20 ? 684 ARG A NH2 1 
ATOM 4972 N N   . PHE A 1 642 ? 122.797 98.049  99.659  1.00 53.12 ? 685 PHE A N   1 
ATOM 4973 C CA  . PHE A 1 642 ? 123.087 99.420  99.274  1.00 46.83 ? 685 PHE A CA  1 
ATOM 4974 C C   . PHE A 1 642 ? 124.378 99.862  99.947  1.00 47.66 ? 685 PHE A C   1 
ATOM 4975 O O   . PHE A 1 642 ? 124.827 99.267  100.930 1.00 51.55 ? 685 PHE A O   1 
ATOM 4976 C CB  . PHE A 1 642 ? 121.940 100.375 99.634  1.00 44.41 ? 685 PHE A CB  1 
ATOM 4977 C CG  . PHE A 1 642 ? 121.509 100.299 101.069 1.00 39.52 ? 685 PHE A CG  1 
ATOM 4978 C CD1 . PHE A 1 642 ? 120.593 99.350  101.481 1.00 44.25 ? 685 PHE A CD1 1 
ATOM 4979 C CD2 . PHE A 1 642 ? 122.009 101.187 102.003 1.00 46.87 ? 685 PHE A CD2 1 
ATOM 4980 C CE1 . PHE A 1 642 ? 120.191 99.282  102.797 1.00 50.28 ? 685 PHE A CE1 1 
ATOM 4981 C CE2 . PHE A 1 642 ? 121.610 101.123 103.322 1.00 46.75 ? 685 PHE A CE2 1 
ATOM 4982 C CZ  . PHE A 1 642 ? 120.700 100.170 103.718 1.00 43.81 ? 685 PHE A CZ  1 
ATOM 4983 N N   . SER A 1 643 ? 124.974 100.920 99.399  1.00 52.55 ? 686 SER A N   1 
ATOM 4984 C CA  . SER A 1 643 ? 126.268 101.383 99.888  1.00 51.38 ? 686 SER A CA  1 
ATOM 4985 C C   . SER A 1 643 ? 126.122 102.244 101.139 1.00 53.86 ? 686 SER A C   1 
ATOM 4986 O O   . SER A 1 643 ? 126.664 101.913 102.199 1.00 54.63 ? 686 SER A O   1 
ATOM 4987 C CB  . SER A 1 643 ? 126.995 102.156 98.785  1.00 56.03 ? 686 SER A CB  1 
ATOM 4988 O OG  . SER A 1 643 ? 126.129 103.085 98.157  1.00 54.62 ? 686 SER A OG  1 
ATOM 4989 N N   . ASP A 1 644 ? 125.393 103.353 101.036 1.00 53.04 ? 687 ASP A N   1 
ATOM 4990 C CA  . ASP A 1 644 ? 125.334 104.336 102.111 1.00 48.83 ? 687 ASP A CA  1 
ATOM 4991 C C   . ASP A 1 644 ? 123.936 104.537 102.672 1.00 48.67 ? 687 ASP A C   1 
ATOM 4992 O O   . ASP A 1 644 ? 123.761 104.526 103.896 1.00 59.48 ? 687 ASP A O   1 
ATOM 4993 C CB  . ASP A 1 644 ? 125.893 105.680 101.618 1.00 54.00 ? 687 ASP A CB  1 
ATOM 4994 C CG  . ASP A 1 644 ? 127.172 105.521 100.821 1.00 58.75 ? 687 ASP A CG  1 
ATOM 4995 O OD1 . ASP A 1 644 ? 128.041 104.729 101.240 1.00 54.44 ? 687 ASP A OD1 1 
ATOM 4996 O OD2 . ASP A 1 644 ? 127.308 106.190 99.774  1.00 60.75 ? 687 ASP A OD2 1 
ATOM 4997 N N   . TYR A 1 645 ? 122.931 104.721 101.820 1.00 39.21 ? 688 TYR A N   1 
ATOM 4998 C CA  . TYR A 1 645 ? 121.610 105.131 102.270 1.00 37.53 ? 688 TYR A CA  1 
ATOM 4999 C C   . TYR A 1 645 ? 120.539 104.357 101.517 1.00 42.76 ? 688 TYR A C   1 
ATOM 5000 O O   . TYR A 1 645 ? 120.804 103.700 100.507 1.00 57.52 ? 688 TYR A O   1 
ATOM 5001 C CB  . TYR A 1 645 ? 121.401 106.639 102.078 1.00 44.99 ? 688 TYR A CB  1 
ATOM 5002 C CG  . TYR A 1 645 ? 121.614 107.105 100.655 1.00 40.24 ? 688 TYR A CG  1 
ATOM 5003 C CD1 . TYR A 1 645 ? 120.576 107.087 99.734  1.00 43.13 ? 688 TYR A CD1 1 
ATOM 5004 C CD2 . TYR A 1 645 ? 122.853 107.561 100.233 1.00 44.49 ? 688 TYR A CD2 1 
ATOM 5005 C CE1 . TYR A 1 645 ? 120.767 107.507 98.435  1.00 50.50 ? 688 TYR A CE1 1 
ATOM 5006 C CE2 . TYR A 1 645 ? 123.053 107.984 98.936  1.00 49.98 ? 688 TYR A CE2 1 
ATOM 5007 C CZ  . TYR A 1 645 ? 122.007 107.956 98.042  1.00 51.33 ? 688 TYR A CZ  1 
ATOM 5008 O OH  . TYR A 1 645 ? 122.203 108.378 96.748  1.00 50.65 ? 688 TYR A OH  1 
ATOM 5009 N N   . LEU A 1 646 ? 119.312 104.447 102.026 1.00 34.20 ? 689 LEU A N   1 
ATOM 5010 C CA  . LEU A 1 646 ? 118.153 103.874 101.347 1.00 36.76 ? 689 LEU A CA  1 
ATOM 5011 C C   . LEU A 1 646 ? 116.923 104.650 101.794 1.00 44.34 ? 689 LEU A C   1 
ATOM 5012 O O   . LEU A 1 646 ? 116.493 104.517 102.943 1.00 51.22 ? 689 LEU A O   1 
ATOM 5013 C CB  . LEU A 1 646 ? 118.009 102.390 101.657 1.00 42.62 ? 689 LEU A CB  1 
ATOM 5014 C CG  . LEU A 1 646 ? 116.883 101.679 100.904 1.00 41.27 ? 689 LEU A CG  1 
ATOM 5015 C CD1 . LEU A 1 646 ? 117.301 101.372 99.478  1.00 45.23 ? 689 LEU A CD1 1 
ATOM 5016 C CD2 . LEU A 1 646 ? 116.462 100.412 101.624 1.00 45.74 ? 689 LEU A CD2 1 
ATOM 5017 N N   . LEU A 1 647 ? 116.366 105.454 100.893 1.00 48.30 ? 690 LEU A N   1 
ATOM 5018 C CA  . LEU A 1 647 ? 115.157 106.226 101.150 1.00 42.95 ? 690 LEU A CA  1 
ATOM 5019 C C   . LEU A 1 647 ? 113.996 105.551 100.434 1.00 40.27 ? 690 LEU A C   1 
ATOM 5020 O O   . LEU A 1 647 ? 114.062 105.323 99.222  1.00 53.69 ? 690 LEU A O   1 
ATOM 5021 C CB  . LEU A 1 647 ? 115.318 107.671 100.677 1.00 41.71 ? 690 LEU A CB  1 
ATOM 5022 C CG  . LEU A 1 647 ? 116.523 108.469 101.180 1.00 43.17 ? 690 LEU A CG  1 
ATOM 5023 C CD1 . LEU A 1 647 ? 116.265 109.957 101.033 1.00 48.66 ? 690 LEU A CD1 1 
ATOM 5024 C CD2 . LEU A 1 647 ? 116.837 108.133 102.628 1.00 46.24 ? 690 LEU A CD2 1 
ATOM 5025 N N   . VAL A 1 648 ? 112.941 105.225 101.180 1.00 25.64 ? 691 VAL A N   1 
ATOM 5026 C CA  . VAL A 1 648 ? 111.805 104.493 100.638 1.00 28.92 ? 691 VAL A CA  1 
ATOM 5027 C C   . VAL A 1 648 ? 110.511 105.077 101.187 1.00 35.86 ? 691 VAL A C   1 
ATOM 5028 O O   . VAL A 1 648 ? 110.497 105.797 102.187 1.00 42.81 ? 691 VAL A O   1 
ATOM 5029 C CB  . VAL A 1 648 ? 111.879 102.984 100.958 1.00 39.33 ? 691 VAL A CB  1 
ATOM 5030 C CG1 . VAL A 1 648 ? 112.896 102.297 100.064 1.00 40.02 ? 691 VAL A CG1 1 
ATOM 5031 C CG2 . VAL A 1 648 ? 112.219 102.769 102.420 1.00 43.58 ? 691 VAL A CG2 1 
ATOM 5032 N N   . LYS A 1 649 ? 109.412 104.752 100.509 1.00 36.99 ? 692 LYS A N   1 
ATOM 5033 C CA  . LYS A 1 649 ? 108.073 105.083 100.972 1.00 26.50 ? 692 LYS A CA  1 
ATOM 5034 C C   . LYS A 1 649 ? 107.152 103.909 100.679 1.00 22.23 ? 692 LYS A C   1 
ATOM 5035 O O   . LYS A 1 649 ? 107.385 103.135 99.748  1.00 40.75 ? 692 LYS A O   1 
ATOM 5036 C CB  . LYS A 1 649 ? 107.534 106.359 100.314 1.00 38.87 ? 692 LYS A CB  1 
ATOM 5037 C CG  . LYS A 1 649 ? 107.102 106.189 98.869  1.00 46.80 ? 692 LYS A CG  1 
ATOM 5038 C CD  . LYS A 1 649 ? 106.877 107.536 98.205  1.00 44.75 ? 692 LYS A CD  1 
ATOM 5039 C CE  . LYS A 1 649 ? 106.857 107.412 96.693  1.00 45.35 ? 692 LYS A CE  1 
ATOM 5040 N NZ  . LYS A 1 649 ? 106.988 108.737 96.030  1.00 46.02 ? 692 LYS A NZ  1 
ATOM 5041 N N   . ALA A 1 650 ? 106.108 103.780 101.485 1.00 26.30 ? 693 ALA A N   1 
ATOM 5042 C CA  . ALA A 1 650 ? 105.167 102.668 101.390 1.00 40.58 ? 693 ALA A CA  1 
ATOM 5043 C C   . ALA A 1 650 ? 103.923 103.151 100.653 1.00 47.92 ? 693 ALA A C   1 
ATOM 5044 O O   . ALA A 1 650 ? 103.074 103.836 101.230 1.00 50.78 ? 693 ALA A O   1 
ATOM 5045 C CB  . ALA A 1 650 ? 104.821 102.129 102.774 1.00 47.74 ? 693 ALA A CB  1 
ATOM 5046 N N   . VAL A 1 651 ? 103.819 102.791 99.378  1.00 40.32 ? 694 VAL A N   1 
ATOM 5047 C CA  . VAL A 1 651 ? 102.661 103.156 98.570  1.00 37.83 ? 694 VAL A CA  1 
ATOM 5048 C C   . VAL A 1 651 ? 101.628 102.040 98.663  1.00 33.96 ? 694 VAL A C   1 
ATOM 5049 O O   . VAL A 1 651 ? 101.911 100.888 98.320  1.00 44.62 ? 694 VAL A O   1 
ATOM 5050 C CB  . VAL A 1 651 ? 103.062 103.421 97.113  1.00 40.63 ? 694 VAL A CB  1 
ATOM 5051 C CG1 . VAL A 1 651 ? 101.834 103.747 96.278  1.00 44.00 ? 694 VAL A CG1 1 
ATOM 5052 C CG2 . VAL A 1 651 ? 104.069 104.551 97.042  1.00 34.76 ? 694 VAL A CG2 1 
ATOM 5053 N N   . GLU A 1 652 ? 100.432 102.382 99.132  1.00 37.05 ? 695 GLU A N   1 
ATOM 5054 C CA  . GLU A 1 652 ? 99.359  101.405 99.243  1.00 42.59 ? 695 GLU A CA  1 
ATOM 5055 C C   . GLU A 1 652 ? 98.898  100.949 97.865  1.00 50.17 ? 695 GLU A C   1 
ATOM 5056 O O   . GLU A 1 652 ? 98.832  101.739 96.920  1.00 55.48 ? 695 GLU A O   1 
ATOM 5057 C CB  . GLU A 1 652 ? 98.184  102.001 100.015 1.00 46.03 ? 695 GLU A CB  1 
ATOM 5058 C CG  . GLU A 1 652 ? 97.291  100.976 100.684 1.00 53.09 ? 695 GLU A CG  1 
ATOM 5059 C CD  . GLU A 1 652 ? 95.884  101.492 100.902 1.00 56.74 ? 695 GLU A CD  1 
ATOM 5060 O OE1 . GLU A 1 652 ? 95.385  102.244 100.038 1.00 52.86 ? 695 GLU A OE1 1 
ATOM 5061 O OE2 . GLU A 1 652 ? 95.274  101.147 101.934 1.00 58.40 ? 695 GLU A OE2 1 
ATOM 5062 N N   . ILE A 1 653 ? 98.578  99.662  97.754  1.00 47.08 ? 696 ILE A N   1 
ATOM 5063 C CA  . ILE A 1 653 ? 98.055  99.078  96.526  1.00 44.66 ? 696 ILE A CA  1 
ATOM 5064 C C   . ILE A 1 653 ? 96.830  98.244  96.870  1.00 52.52 ? 696 ILE A C   1 
ATOM 5065 O O   . ILE A 1 653 ? 96.818  97.523  97.874  1.00 58.87 ? 696 ILE A O   1 
ATOM 5066 C CB  . ILE A 1 653 ? 99.114  98.225  95.795  1.00 46.14 ? 696 ILE A CB  1 
ATOM 5067 C CG1 . ILE A 1 653 ? 99.747  97.211  96.748  1.00 51.45 ? 696 ILE A CG1 1 
ATOM 5068 C CG2 . ILE A 1 653 ? 100.179 99.113  95.175  1.00 51.45 ? 696 ILE A CG2 1 
ATOM 5069 C CD1 . ILE A 1 653 ? 100.337 96.008  96.050  1.00 51.05 ? 696 ILE A CD1 1 
ATOM 5070 N N   . SER A 1 654 ? 95.792  98.354  96.041  1.00 54.00 ? 697 SER A N   1 
ATOM 5071 C CA  . SER A 1 654 ? 94.549  97.629  96.276  1.00 52.39 ? 697 SER A CA  1 
ATOM 5072 C C   . SER A 1 654 ? 94.588  96.202  95.748  1.00 53.26 ? 697 SER A C   1 
ATOM 5073 O O   . SER A 1 654 ? 93.895  95.332  96.287  1.00 52.70 ? 697 SER A O   1 
ATOM 5074 C CB  . SER A 1 654 ? 93.375  98.375  95.638  1.00 58.67 ? 697 SER A CB  1 
ATOM 5075 O OG  . SER A 1 654 ? 92.302  97.492  95.359  1.00 61.09 ? 697 SER A OG  1 
ATOM 5076 N N   . GLU A 1 655 ? 95.375  95.942  94.710  1.00 59.27 ? 698 GLU A N   1 
ATOM 5077 C CA  . GLU A 1 655 ? 95.498  94.620  94.122  1.00 56.38 ? 698 GLU A CA  1 
ATOM 5078 C C   . GLU A 1 655 ? 96.968  94.259  93.970  1.00 59.36 ? 698 GLU A C   1 
ATOM 5079 O O   . GLU A 1 655 ? 97.815  95.144  93.814  1.00 61.62 ? 698 GLU A O   1 
ATOM 5080 C CB  . GLU A 1 655 ? 94.804  94.555  92.754  1.00 61.57 ? 698 GLU A CB  1 
ATOM 5081 C CG  . GLU A 1 655 ? 93.321  94.888  92.794  1.00 65.28 ? 698 GLU A CG  1 
ATOM 5082 C CD  . GLU A 1 655 ? 92.544  93.981  93.729  1.00 67.15 ? 698 GLU A CD  1 
ATOM 5083 O OE1 . GLU A 1 655 ? 92.841  92.768  93.768  1.00 63.01 ? 698 GLU A OE1 1 
ATOM 5084 O OE2 . GLU A 1 655 ? 91.636  94.481  94.426  1.00 67.14 ? 698 GLU A OE2 1 
ATOM 5085 N N   . PRO A 1 656 ? 97.299  92.969  94.021  1.00 50.54 ? 699 PRO A N   1 
ATOM 5086 C CA  . PRO A 1 656 ? 98.708  92.567  93.932  1.00 46.42 ? 699 PRO A CA  1 
ATOM 5087 C C   . PRO A 1 656 ? 99.331  92.959  92.601  1.00 45.09 ? 699 PRO A C   1 
ATOM 5088 O O   . PRO A 1 656 ? 98.681  92.935  91.554  1.00 49.99 ? 699 PRO A O   1 
ATOM 5089 C CB  . PRO A 1 656 ? 98.653  91.044  94.095  1.00 49.20 ? 699 PRO A CB  1 
ATOM 5090 C CG  . PRO A 1 656 ? 97.368  90.778  94.795  1.00 53.01 ? 699 PRO A CG  1 
ATOM 5091 C CD  . PRO A 1 656 ? 96.415  91.828  94.316  1.00 53.47 ? 699 PRO A CD  1 
ATOM 5092 N N   . ASP A 1 657 ? 100.609 93.327  92.655  1.00 41.63 ? 700 ASP A N   1 
ATOM 5093 C CA  . ASP A 1 657 ? 101.367 93.626  91.456  1.00 40.46 ? 700 ASP A CA  1 
ATOM 5094 C C   . ASP A 1 657 ? 101.708 92.337  90.711  1.00 49.24 ? 700 ASP A C   1 
ATOM 5095 O O   . ASP A 1 657 ? 101.784 91.263  91.312  1.00 55.70 ? 700 ASP A O   1 
ATOM 5096 C CB  . ASP A 1 657 ? 102.645 94.380  91.813  1.00 46.29 ? 700 ASP A CB  1 
ATOM 5097 C CG  . ASP A 1 657 ? 102.485 95.882  91.705  1.00 53.96 ? 700 ASP A CG  1 
ATOM 5098 O OD1 . ASP A 1 657 ? 101.335 96.365  91.754  1.00 59.04 ? 700 ASP A OD1 1 
ATOM 5099 O OD2 . ASP A 1 657 ? 103.511 96.580  91.571  1.00 53.28 ? 700 ASP A OD2 1 
ATOM 5100 N N   . PRO A 1 658 ? 101.921 92.417  89.388  1.00 47.36 ? 701 PRO A N   1 
ATOM 5101 C CA  . PRO A 1 658 ? 102.287 91.235  88.607  1.00 46.19 ? 701 PRO A CA  1 
ATOM 5102 C C   . PRO A 1 658 ? 103.790 90.976  88.605  1.00 51.92 ? 701 PRO A C   1 
ATOM 5103 O O   . PRO A 1 658 ? 104.330 90.602  87.564  1.00 50.44 ? 701 PRO A O   1 
ATOM 5104 C CB  . PRO A 1 658 ? 101.789 91.583  87.193  1.00 47.90 ? 701 PRO A CB  1 
ATOM 5105 C CG  . PRO A 1 658 ? 101.230 93.014  87.290  1.00 50.41 ? 701 PRO A CG  1 
ATOM 5106 C CD  . PRO A 1 658 ? 101.836 93.597  88.519  1.00 49.14 ? 701 PRO A CD  1 
# 
