data_8X04
# 
_entry.id   8X04 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8X04         pdb_00008x04 10.2210/pdb8x04/pdb 
WWPDB D_1300042375 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8X04 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 8WXC unspecified 
PDB . 8WY2 unspecified 
PDB . 8WYV unspecified 
PDB . 8X00 unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              aquarius@g.ecc.u-tokyo.ac.jp 
_pdbx_contact_author.name_first         Kiyohiko 
_pdbx_contact_author.name_last          Igarashi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5152-7177 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yamaguchi, S.' 1 ? 
'Sunagawa, N.'  2 ? 
'Tachioka, M.'  3 ? 
'Igarashi, K.'  4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Activity and X-ray crystal structure of candidate base catalyst mutants of glycoside hydrolase family 6 cellobiohydrolase' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yamaguchi, S.' 1 ? 
primary 'Sunagawa, N.'  2 ? 
primary 'Tachioka, M.'  3 ? 
primary 'Igarashi, K.'  4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Glucanase                                38305.438 1   ? 'C240S, C393S, D394A' ? ? 
2 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   1   ? ?                     ? ? 
3 water       nat water                                    18.015    532 ? ?                     ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLASV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGESAGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLASV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGESAGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
3 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   ALA n 
1 3   ASN n 
1 4   ASN n 
1 5   PRO n 
1 6   TRP n 
1 7   THR n 
1 8   GLY n 
1 9   PHE n 
1 10  GLN n 
1 11  ILE n 
1 12  PHE n 
1 13  LEU n 
1 14  SER n 
1 15  PRO n 
1 16  TYR n 
1 17  TYR n 
1 18  ALA n 
1 19  ASN n 
1 20  GLU n 
1 21  VAL n 
1 22  ALA n 
1 23  ALA n 
1 24  ALA n 
1 25  ALA n 
1 26  LYS n 
1 27  GLN n 
1 28  ILE n 
1 29  THR n 
1 30  ASP n 
1 31  PRO n 
1 32  THR n 
1 33  LEU n 
1 34  SER n 
1 35  SER n 
1 36  LYS n 
1 37  ALA n 
1 38  ALA n 
1 39  SER n 
1 40  VAL n 
1 41  ALA n 
1 42  ASN n 
1 43  ILE n 
1 44  PRO n 
1 45  THR n 
1 46  PHE n 
1 47  THR n 
1 48  TRP n 
1 49  LEU n 
1 50  ASP n 
1 51  SER n 
1 52  VAL n 
1 53  ALA n 
1 54  LYS n 
1 55  ILE n 
1 56  PRO n 
1 57  ASP n 
1 58  LEU n 
1 59  GLY n 
1 60  THR n 
1 61  TYR n 
1 62  LEU n 
1 63  ALA n 
1 64  SER n 
1 65  ALA n 
1 66  SER n 
1 67  ALA n 
1 68  LEU n 
1 69  GLY n 
1 70  LYS n 
1 71  SER n 
1 72  THR n 
1 73  GLY n 
1 74  THR n 
1 75  LYS n 
1 76  GLN n 
1 77  LEU n 
1 78  VAL n 
1 79  GLN n 
1 80  ILE n 
1 81  VAL n 
1 82  ILE n 
1 83  TYR n 
1 84  ASP n 
1 85  LEU n 
1 86  PRO n 
1 87  ASP n 
1 88  ARG n 
1 89  ASP n 
1 90  CYS n 
1 91  ALA n 
1 92  ALA n 
1 93  LYS n 
1 94  ALA n 
1 95  SER n 
1 96  ASN n 
1 97  GLY n 
1 98  GLU n 
1 99  PHE n 
1 100 SER n 
1 101 ILE n 
1 102 ALA n 
1 103 ASN n 
1 104 ASN n 
1 105 GLY n 
1 106 GLN n 
1 107 ALA n 
1 108 ASN n 
1 109 TYR n 
1 110 GLU n 
1 111 ASN n 
1 112 TYR n 
1 113 ILE n 
1 114 ASP n 
1 115 GLN n 
1 116 ILE n 
1 117 VAL n 
1 118 ALA n 
1 119 GLN n 
1 120 ILE n 
1 121 GLN n 
1 122 GLN n 
1 123 PHE n 
1 124 PRO n 
1 125 ASP n 
1 126 VAL n 
1 127 ARG n 
1 128 VAL n 
1 129 VAL n 
1 130 ALA n 
1 131 VAL n 
1 132 ILE n 
1 133 GLU n 
1 134 PRO n 
1 135 ASP n 
1 136 SER n 
1 137 LEU n 
1 138 ALA n 
1 139 ASN n 
1 140 LEU n 
1 141 VAL n 
1 142 THR n 
1 143 ASN n 
1 144 LEU n 
1 145 ASN n 
1 146 VAL n 
1 147 GLN n 
1 148 LYS n 
1 149 CYS n 
1 150 ALA n 
1 151 ASN n 
1 152 ALA n 
1 153 LYS n 
1 154 THR n 
1 155 THR n 
1 156 TYR n 
1 157 LEU n 
1 158 ALA n 
1 159 SER n 
1 160 VAL n 
1 161 ASN n 
1 162 TYR n 
1 163 ALA n 
1 164 LEU n 
1 165 THR n 
1 166 ASN n 
1 167 LEU n 
1 168 ALA n 
1 169 LYS n 
1 170 VAL n 
1 171 GLY n 
1 172 VAL n 
1 173 TYR n 
1 174 MET n 
1 175 TYR n 
1 176 MET n 
1 177 ASP n 
1 178 ALA n 
1 179 GLY n 
1 180 HIS n 
1 181 ALA n 
1 182 GLY n 
1 183 TRP n 
1 184 LEU n 
1 185 GLY n 
1 186 TRP n 
1 187 PRO n 
1 188 ALA n 
1 189 ASN n 
1 190 LEU n 
1 191 SER n 
1 192 PRO n 
1 193 ALA n 
1 194 ALA n 
1 195 GLN n 
1 196 LEU n 
1 197 PHE n 
1 198 THR n 
1 199 GLN n 
1 200 VAL n 
1 201 TRP n 
1 202 GLN n 
1 203 ASN n 
1 204 ALA n 
1 205 GLY n 
1 206 LYS n 
1 207 SER n 
1 208 PRO n 
1 209 PHE n 
1 210 ILE n 
1 211 LYS n 
1 212 GLY n 
1 213 LEU n 
1 214 ALA n 
1 215 THR n 
1 216 ASN n 
1 217 VAL n 
1 218 ALA n 
1 219 ASN n 
1 220 TYR n 
1 221 ASN n 
1 222 ALA n 
1 223 LEU n 
1 224 GLN n 
1 225 ALA n 
1 226 ALA n 
1 227 SER n 
1 228 PRO n 
1 229 ASP n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 GLN n 
1 234 GLY n 
1 235 ASN n 
1 236 PRO n 
1 237 ASN n 
1 238 TYR n 
1 239 ASP n 
1 240 GLU n 
1 241 ILE n 
1 242 HIS n 
1 243 TYR n 
1 244 ILE n 
1 245 ASN n 
1 246 ALA n 
1 247 LEU n 
1 248 ALA n 
1 249 PRO n 
1 250 LEU n 
1 251 LEU n 
1 252 GLN n 
1 253 GLN n 
1 254 ALA n 
1 255 GLY n 
1 256 TRP n 
1 257 ASP n 
1 258 ALA n 
1 259 THR n 
1 260 PHE n 
1 261 ILE n 
1 262 VAL n 
1 263 ASP n 
1 264 GLN n 
1 265 GLY n 
1 266 ARG n 
1 267 SER n 
1 268 GLY n 
1 269 VAL n 
1 270 GLN n 
1 271 ASN n 
1 272 ILE n 
1 273 ARG n 
1 274 GLN n 
1 275 GLN n 
1 276 TRP n 
1 277 GLY n 
1 278 ASP n 
1 279 TRP n 
1 280 CYS n 
1 281 ASN n 
1 282 ILE n 
1 283 LYS n 
1 284 GLY n 
1 285 ALA n 
1 286 GLY n 
1 287 PHE n 
1 288 GLY n 
1 289 THR n 
1 290 ARG n 
1 291 PRO n 
1 292 THR n 
1 293 THR n 
1 294 ASN n 
1 295 THR n 
1 296 GLY n 
1 297 SER n 
1 298 GLN n 
1 299 PHE n 
1 300 ILE n 
1 301 ASP n 
1 302 SER n 
1 303 ILE n 
1 304 VAL n 
1 305 TRP n 
1 306 VAL n 
1 307 LYS n 
1 308 PRO n 
1 309 GLY n 
1 310 GLY n 
1 311 GLU n 
1 312 SER n 
1 313 ALA n 
1 314 GLY n 
1 315 THR n 
1 316 SER n 
1 317 ASN n 
1 318 SER n 
1 319 SER n 
1 320 SER n 
1 321 PRO n 
1 322 ARG n 
1 323 TYR n 
1 324 ASP n 
1 325 SER n 
1 326 THR n 
1 327 CYS n 
1 328 SER n 
1 329 LEU n 
1 330 PRO n 
1 331 ASP n 
1 332 ALA n 
1 333 ALA n 
1 334 GLN n 
1 335 PRO n 
1 336 ALA n 
1 337 PRO n 
1 338 GLU n 
1 339 ALA n 
1 340 GLY n 
1 341 THR n 
1 342 TRP n 
1 343 PHE n 
1 344 GLN n 
1 345 ALA n 
1 346 TYR n 
1 347 PHE n 
1 348 GLN n 
1 349 THR n 
1 350 LEU n 
1 351 VAL n 
1 352 SER n 
1 353 ALA n 
1 354 ALA n 
1 355 ASN n 
1 356 PRO n 
1 357 PRO n 
1 358 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   358 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 cel6A 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    K-3 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Phanerodontia chrysosporium' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2822231 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Komagataella pastoris' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     4922 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               KM71H 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pPICZalpha 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   82  82  SER SER A . n 
A 1 2   ALA 2   83  83  ALA ALA A . n 
A 1 3   ASN 3   84  84  ASN ASN A . n 
A 1 4   ASN 4   85  85  ASN ASN A . n 
A 1 5   PRO 5   86  86  PRO PRO A . n 
A 1 6   TRP 6   87  87  TRP TRP A . n 
A 1 7   THR 7   88  88  THR THR A . n 
A 1 8   GLY 8   89  89  GLY GLY A . n 
A 1 9   PHE 9   90  90  PHE PHE A . n 
A 1 10  GLN 10  91  91  GLN GLN A . n 
A 1 11  ILE 11  92  92  ILE ILE A . n 
A 1 12  PHE 12  93  93  PHE PHE A . n 
A 1 13  LEU 13  94  94  LEU LEU A . n 
A 1 14  SER 14  95  95  SER SER A . n 
A 1 15  PRO 15  96  96  PRO PRO A . n 
A 1 16  TYR 16  97  97  TYR TYR A . n 
A 1 17  TYR 17  98  98  TYR TYR A . n 
A 1 18  ALA 18  99  99  ALA ALA A . n 
A 1 19  ASN 19  100 100 ASN ASN A . n 
A 1 20  GLU 20  101 101 GLU GLU A . n 
A 1 21  VAL 21  102 102 VAL VAL A . n 
A 1 22  ALA 22  103 103 ALA ALA A . n 
A 1 23  ALA 23  104 104 ALA ALA A . n 
A 1 24  ALA 24  105 105 ALA ALA A . n 
A 1 25  ALA 25  106 106 ALA ALA A . n 
A 1 26  LYS 26  107 107 LYS LYS A . n 
A 1 27  GLN 27  108 108 GLN GLN A . n 
A 1 28  ILE 28  109 109 ILE ILE A . n 
A 1 29  THR 29  110 110 THR THR A . n 
A 1 30  ASP 30  111 111 ASP ASP A . n 
A 1 31  PRO 31  112 112 PRO PRO A . n 
A 1 32  THR 32  113 113 THR THR A . n 
A 1 33  LEU 33  114 114 LEU LEU A . n 
A 1 34  SER 34  115 115 SER SER A . n 
A 1 35  SER 35  116 116 SER SER A . n 
A 1 36  LYS 36  117 117 LYS LYS A . n 
A 1 37  ALA 37  118 118 ALA ALA A . n 
A 1 38  ALA 38  119 119 ALA ALA A . n 
A 1 39  SER 39  120 120 SER SER A . n 
A 1 40  VAL 40  121 121 VAL VAL A . n 
A 1 41  ALA 41  122 122 ALA ALA A . n 
A 1 42  ASN 42  123 123 ASN ASN A . n 
A 1 43  ILE 43  124 124 ILE ILE A . n 
A 1 44  PRO 44  125 125 PRO PRO A . n 
A 1 45  THR 45  126 126 THR THR A . n 
A 1 46  PHE 46  127 127 PHE PHE A . n 
A 1 47  THR 47  128 128 THR THR A . n 
A 1 48  TRP 48  129 129 TRP TRP A . n 
A 1 49  LEU 49  130 130 LEU LEU A . n 
A 1 50  ASP 50  131 131 ASP ASP A . n 
A 1 51  SER 51  132 132 SER SER A . n 
A 1 52  VAL 52  133 133 VAL VAL A . n 
A 1 53  ALA 53  134 134 ALA ALA A . n 
A 1 54  LYS 54  135 135 LYS LYS A . n 
A 1 55  ILE 55  136 136 ILE ILE A . n 
A 1 56  PRO 56  137 137 PRO PRO A . n 
A 1 57  ASP 57  138 138 ASP ASP A . n 
A 1 58  LEU 58  139 139 LEU LEU A . n 
A 1 59  GLY 59  140 140 GLY GLY A . n 
A 1 60  THR 60  141 141 THR THR A . n 
A 1 61  TYR 61  142 142 TYR TYR A . n 
A 1 62  LEU 62  143 143 LEU LEU A . n 
A 1 63  ALA 63  144 144 ALA ALA A . n 
A 1 64  SER 64  145 145 SER SER A . n 
A 1 65  ALA 65  146 146 ALA ALA A . n 
A 1 66  SER 66  147 147 SER SER A . n 
A 1 67  ALA 67  148 148 ALA ALA A . n 
A 1 68  LEU 68  149 149 LEU LEU A . n 
A 1 69  GLY 69  150 150 GLY GLY A . n 
A 1 70  LYS 70  151 151 LYS LYS A . n 
A 1 71  SER 71  152 152 SER SER A . n 
A 1 72  THR 72  153 153 THR THR A . n 
A 1 73  GLY 73  154 154 GLY GLY A . n 
A 1 74  THR 74  155 155 THR THR A . n 
A 1 75  LYS 75  156 156 LYS LYS A . n 
A 1 76  GLN 76  157 157 GLN GLN A . n 
A 1 77  LEU 77  158 158 LEU LEU A . n 
A 1 78  VAL 78  159 159 VAL VAL A . n 
A 1 79  GLN 79  160 160 GLN GLN A . n 
A 1 80  ILE 80  161 161 ILE ILE A . n 
A 1 81  VAL 81  162 162 VAL VAL A . n 
A 1 82  ILE 82  163 163 ILE ILE A . n 
A 1 83  TYR 83  164 164 TYR TYR A . n 
A 1 84  ASP 84  165 165 ASP ASP A . n 
A 1 85  LEU 85  166 166 LEU LEU A . n 
A 1 86  PRO 86  167 167 PRO PRO A . n 
A 1 87  ASP 87  168 168 ASP ASP A . n 
A 1 88  ARG 88  169 169 ARG ARG A . n 
A 1 89  ASP 89  170 170 ASP ASP A . n 
A 1 90  CYS 90  171 171 CYS CYS A . n 
A 1 91  ALA 91  172 172 ALA ALA A . n 
A 1 92  ALA 92  173 173 ALA ALA A . n 
A 1 93  LYS 93  174 174 LYS LYS A . n 
A 1 94  ALA 94  175 175 ALA ALA A . n 
A 1 95  SER 95  176 176 SER SER A . n 
A 1 96  ASN 96  177 177 ASN ASN A . n 
A 1 97  GLY 97  178 178 GLY GLY A . n 
A 1 98  GLU 98  179 179 GLU GLU A . n 
A 1 99  PHE 99  180 180 PHE PHE A . n 
A 1 100 SER 100 181 181 SER SER A . n 
A 1 101 ILE 101 182 182 ILE ILE A . n 
A 1 102 ALA 102 183 183 ALA ALA A . n 
A 1 103 ASN 103 184 184 ASN ASN A . n 
A 1 104 ASN 104 185 185 ASN ASN A . n 
A 1 105 GLY 105 186 186 GLY GLY A . n 
A 1 106 GLN 106 187 187 GLN GLN A . n 
A 1 107 ALA 107 188 188 ALA ALA A . n 
A 1 108 ASN 108 189 189 ASN ASN A . n 
A 1 109 TYR 109 190 190 TYR TYR A . n 
A 1 110 GLU 110 191 191 GLU GLU A . n 
A 1 111 ASN 111 192 192 ASN ASN A . n 
A 1 112 TYR 112 193 193 TYR TYR A . n 
A 1 113 ILE 113 194 194 ILE ILE A . n 
A 1 114 ASP 114 195 195 ASP ASP A . n 
A 1 115 GLN 115 196 196 GLN GLN A . n 
A 1 116 ILE 116 197 197 ILE ILE A . n 
A 1 117 VAL 117 198 198 VAL VAL A . n 
A 1 118 ALA 118 199 199 ALA ALA A . n 
A 1 119 GLN 119 200 200 GLN GLN A . n 
A 1 120 ILE 120 201 201 ILE ILE A . n 
A 1 121 GLN 121 202 202 GLN GLN A . n 
A 1 122 GLN 122 203 203 GLN GLN A . n 
A 1 123 PHE 123 204 204 PHE PHE A . n 
A 1 124 PRO 124 205 205 PRO PRO A . n 
A 1 125 ASP 125 206 206 ASP ASP A . n 
A 1 126 VAL 126 207 207 VAL VAL A . n 
A 1 127 ARG 127 208 208 ARG ARG A . n 
A 1 128 VAL 128 209 209 VAL VAL A . n 
A 1 129 VAL 129 210 210 VAL VAL A . n 
A 1 130 ALA 130 211 211 ALA ALA A . n 
A 1 131 VAL 131 212 212 VAL VAL A . n 
A 1 132 ILE 132 213 213 ILE ILE A . n 
A 1 133 GLU 133 214 214 GLU GLU A . n 
A 1 134 PRO 134 215 215 PRO PRO A . n 
A 1 135 ASP 135 216 216 ASP ASP A . n 
A 1 136 SER 136 217 217 SER SER A . n 
A 1 137 LEU 137 218 218 LEU LEU A . n 
A 1 138 ALA 138 219 219 ALA ALA A . n 
A 1 139 ASN 139 220 220 ASN ASN A . n 
A 1 140 LEU 140 221 221 LEU LEU A . n 
A 1 141 VAL 141 222 222 VAL VAL A . n 
A 1 142 THR 142 223 223 THR THR A . n 
A 1 143 ASN 143 224 224 ASN ASN A . n 
A 1 144 LEU 144 225 225 LEU LEU A . n 
A 1 145 ASN 145 226 226 ASN ASN A . n 
A 1 146 VAL 146 227 227 VAL VAL A . n 
A 1 147 GLN 147 228 228 GLN GLN A . n 
A 1 148 LYS 148 229 229 LYS LYS A . n 
A 1 149 CYS 149 230 230 CYS CYS A . n 
A 1 150 ALA 150 231 231 ALA ALA A . n 
A 1 151 ASN 151 232 232 ASN ASN A . n 
A 1 152 ALA 152 233 233 ALA ALA A . n 
A 1 153 LYS 153 234 234 LYS LYS A . n 
A 1 154 THR 154 235 235 THR THR A . n 
A 1 155 THR 155 236 236 THR THR A . n 
A 1 156 TYR 156 237 237 TYR TYR A . n 
A 1 157 LEU 157 238 238 LEU LEU A . n 
A 1 158 ALA 158 239 239 ALA ALA A . n 
A 1 159 SER 159 240 240 SER SER A . n 
A 1 160 VAL 160 241 241 VAL VAL A . n 
A 1 161 ASN 161 242 242 ASN ASN A . n 
A 1 162 TYR 162 243 243 TYR TYR A . n 
A 1 163 ALA 163 244 244 ALA ALA A . n 
A 1 164 LEU 164 245 245 LEU LEU A . n 
A 1 165 THR 165 246 246 THR THR A . n 
A 1 166 ASN 166 247 247 ASN ASN A . n 
A 1 167 LEU 167 248 248 LEU LEU A . n 
A 1 168 ALA 168 249 249 ALA ALA A . n 
A 1 169 LYS 169 250 250 LYS LYS A . n 
A 1 170 VAL 170 251 251 VAL VAL A . n 
A 1 171 GLY 171 252 252 GLY GLY A . n 
A 1 172 VAL 172 253 253 VAL VAL A . n 
A 1 173 TYR 173 254 254 TYR TYR A . n 
A 1 174 MET 174 255 255 MET MET A . n 
A 1 175 TYR 175 256 256 TYR TYR A . n 
A 1 176 MET 176 257 257 MET MET A . n 
A 1 177 ASP 177 258 258 ASP ASP A . n 
A 1 178 ALA 178 259 259 ALA ALA A . n 
A 1 179 GLY 179 260 260 GLY GLY A . n 
A 1 180 HIS 180 261 261 HIS HIS A . n 
A 1 181 ALA 181 262 262 ALA ALA A . n 
A 1 182 GLY 182 263 263 GLY GLY A . n 
A 1 183 TRP 183 264 264 TRP TRP A . n 
A 1 184 LEU 184 265 265 LEU LEU A . n 
A 1 185 GLY 185 266 266 GLY GLY A . n 
A 1 186 TRP 186 267 267 TRP TRP A . n 
A 1 187 PRO 187 268 268 PRO PRO A . n 
A 1 188 ALA 188 269 269 ALA ALA A . n 
A 1 189 ASN 189 270 270 ASN ASN A . n 
A 1 190 LEU 190 271 271 LEU LEU A . n 
A 1 191 SER 191 272 272 SER SER A . n 
A 1 192 PRO 192 273 273 PRO PRO A . n 
A 1 193 ALA 193 274 274 ALA ALA A . n 
A 1 194 ALA 194 275 275 ALA ALA A . n 
A 1 195 GLN 195 276 276 GLN GLN A . n 
A 1 196 LEU 196 277 277 LEU LEU A . n 
A 1 197 PHE 197 278 278 PHE PHE A . n 
A 1 198 THR 198 279 279 THR THR A . n 
A 1 199 GLN 199 280 280 GLN GLN A . n 
A 1 200 VAL 200 281 281 VAL VAL A . n 
A 1 201 TRP 201 282 282 TRP TRP A . n 
A 1 202 GLN 202 283 283 GLN GLN A . n 
A 1 203 ASN 203 284 284 ASN ASN A . n 
A 1 204 ALA 204 285 285 ALA ALA A . n 
A 1 205 GLY 205 286 286 GLY GLY A . n 
A 1 206 LYS 206 287 287 LYS LYS A . n 
A 1 207 SER 207 288 288 SER SER A . n 
A 1 208 PRO 208 289 289 PRO PRO A . n 
A 1 209 PHE 209 290 290 PHE PHE A . n 
A 1 210 ILE 210 291 291 ILE ILE A . n 
A 1 211 LYS 211 292 292 LYS LYS A . n 
A 1 212 GLY 212 293 293 GLY GLY A . n 
A 1 213 LEU 213 294 294 LEU LEU A . n 
A 1 214 ALA 214 295 295 ALA ALA A . n 
A 1 215 THR 215 296 296 THR THR A . n 
A 1 216 ASN 216 297 297 ASN ASN A . n 
A 1 217 VAL 217 298 298 VAL VAL A . n 
A 1 218 ALA 218 299 299 ALA ALA A . n 
A 1 219 ASN 219 300 300 ASN ASN A . n 
A 1 220 TYR 220 301 301 TYR TYR A . n 
A 1 221 ASN 221 302 302 ASN ASN A . n 
A 1 222 ALA 222 303 303 ALA ALA A . n 
A 1 223 LEU 223 304 304 LEU LEU A . n 
A 1 224 GLN 224 305 305 GLN GLN A . n 
A 1 225 ALA 225 306 306 ALA ALA A . n 
A 1 226 ALA 226 307 307 ALA ALA A . n 
A 1 227 SER 227 308 308 SER SER A . n 
A 1 228 PRO 228 309 309 PRO PRO A . n 
A 1 229 ASP 229 310 310 ASP ASP A . n 
A 1 230 PRO 230 311 311 PRO PRO A . n 
A 1 231 ILE 231 312 312 ILE ILE A . n 
A 1 232 THR 232 313 313 THR THR A . n 
A 1 233 GLN 233 314 314 GLN GLN A . n 
A 1 234 GLY 234 315 315 GLY GLY A . n 
A 1 235 ASN 235 316 316 ASN ASN A . n 
A 1 236 PRO 236 317 317 PRO PRO A . n 
A 1 237 ASN 237 318 318 ASN ASN A . n 
A 1 238 TYR 238 319 319 TYR TYR A . n 
A 1 239 ASP 239 320 320 ASP ASP A . n 
A 1 240 GLU 240 321 321 GLU GLU A . n 
A 1 241 ILE 241 322 322 ILE ILE A . n 
A 1 242 HIS 242 323 323 HIS HIS A . n 
A 1 243 TYR 243 324 324 TYR TYR A . n 
A 1 244 ILE 244 325 325 ILE ILE A . n 
A 1 245 ASN 245 326 326 ASN ASN A . n 
A 1 246 ALA 246 327 327 ALA ALA A . n 
A 1 247 LEU 247 328 328 LEU LEU A . n 
A 1 248 ALA 248 329 329 ALA ALA A . n 
A 1 249 PRO 249 330 330 PRO PRO A . n 
A 1 250 LEU 250 331 331 LEU LEU A . n 
A 1 251 LEU 251 332 332 LEU LEU A . n 
A 1 252 GLN 252 333 333 GLN GLN A . n 
A 1 253 GLN 253 334 334 GLN GLN A . n 
A 1 254 ALA 254 335 335 ALA ALA A . n 
A 1 255 GLY 255 336 336 GLY GLY A . n 
A 1 256 TRP 256 337 337 TRP TRP A . n 
A 1 257 ASP 257 338 338 ASP ASP A . n 
A 1 258 ALA 258 339 339 ALA ALA A . n 
A 1 259 THR 259 340 340 THR THR A . n 
A 1 260 PHE 260 341 341 PHE PHE A . n 
A 1 261 ILE 261 342 342 ILE ILE A . n 
A 1 262 VAL 262 343 343 VAL VAL A . n 
A 1 263 ASP 263 344 344 ASP ASP A . n 
A 1 264 GLN 264 345 345 GLN GLN A . n 
A 1 265 GLY 265 346 346 GLY GLY A . n 
A 1 266 ARG 266 347 347 ARG ARG A . n 
A 1 267 SER 267 348 348 SER SER A . n 
A 1 268 GLY 268 349 349 GLY GLY A . n 
A 1 269 VAL 269 350 350 VAL VAL A . n 
A 1 270 GLN 270 351 351 GLN GLN A . n 
A 1 271 ASN 271 352 352 ASN ASN A . n 
A 1 272 ILE 272 353 353 ILE ILE A . n 
A 1 273 ARG 273 354 354 ARG ARG A . n 
A 1 274 GLN 274 355 355 GLN GLN A . n 
A 1 275 GLN 275 356 356 GLN GLN A . n 
A 1 276 TRP 276 357 357 TRP TRP A . n 
A 1 277 GLY 277 358 358 GLY GLY A . n 
A 1 278 ASP 278 359 359 ASP ASP A . n 
A 1 279 TRP 279 360 360 TRP TRP A . n 
A 1 280 CYS 280 361 361 CYS CYS A . n 
A 1 281 ASN 281 362 362 ASN ASN A . n 
A 1 282 ILE 282 363 363 ILE ILE A . n 
A 1 283 LYS 283 364 364 LYS LYS A . n 
A 1 284 GLY 284 365 365 GLY GLY A . n 
A 1 285 ALA 285 366 366 ALA ALA A . n 
A 1 286 GLY 286 367 367 GLY GLY A . n 
A 1 287 PHE 287 368 368 PHE PHE A . n 
A 1 288 GLY 288 369 369 GLY GLY A . n 
A 1 289 THR 289 370 370 THR THR A . n 
A 1 290 ARG 290 371 371 ARG ARG A . n 
A 1 291 PRO 291 372 372 PRO PRO A . n 
A 1 292 THR 292 373 373 THR THR A . n 
A 1 293 THR 293 374 374 THR THR A . n 
A 1 294 ASN 294 375 375 ASN ASN A . n 
A 1 295 THR 295 376 376 THR THR A . n 
A 1 296 GLY 296 377 377 GLY GLY A . n 
A 1 297 SER 297 378 378 SER SER A . n 
A 1 298 GLN 298 379 379 GLN GLN A . n 
A 1 299 PHE 299 380 380 PHE PHE A . n 
A 1 300 ILE 300 381 381 ILE ILE A . n 
A 1 301 ASP 301 382 382 ASP ASP A . n 
A 1 302 SER 302 383 383 SER SER A . n 
A 1 303 ILE 303 384 384 ILE ILE A . n 
A 1 304 VAL 304 385 385 VAL VAL A . n 
A 1 305 TRP 305 386 386 TRP TRP A . n 
A 1 306 VAL 306 387 387 VAL VAL A . n 
A 1 307 LYS 307 388 388 LYS LYS A . n 
A 1 308 PRO 308 389 389 PRO PRO A . n 
A 1 309 GLY 309 390 390 GLY GLY A . n 
A 1 310 GLY 310 391 391 GLY GLY A . n 
A 1 311 GLU 311 392 392 GLU GLU A . n 
A 1 312 SER 312 393 393 SER SER A . n 
A 1 313 ALA 313 394 394 ALA ALA A . n 
A 1 314 GLY 314 395 395 GLY GLY A . n 
A 1 315 THR 315 396 396 THR THR A . n 
A 1 316 SER 316 397 397 SER SER A . n 
A 1 317 ASN 317 398 398 ASN ASN A . n 
A 1 318 SER 318 399 399 SER SER A . n 
A 1 319 SER 319 400 400 SER SER A . n 
A 1 320 SER 320 401 401 SER SER A . n 
A 1 321 PRO 321 402 402 PRO PRO A . n 
A 1 322 ARG 322 403 403 ARG ARG A . n 
A 1 323 TYR 323 404 404 TYR TYR A . n 
A 1 324 ASP 324 405 405 ASP ASP A . n 
A 1 325 SER 325 406 406 SER SER A . n 
A 1 326 THR 326 407 407 THR THR A . n 
A 1 327 CYS 327 408 408 CYS CYS A . n 
A 1 328 SER 328 409 409 SER SER A . n 
A 1 329 LEU 329 410 410 LEU LEU A . n 
A 1 330 PRO 330 411 411 PRO PRO A . n 
A 1 331 ASP 331 412 412 ASP ASP A . n 
A 1 332 ALA 332 413 413 ALA ALA A . n 
A 1 333 ALA 333 414 414 ALA ALA A . n 
A 1 334 GLN 334 415 415 GLN GLN A . n 
A 1 335 PRO 335 416 416 PRO PRO A . n 
A 1 336 ALA 336 417 417 ALA ALA A . n 
A 1 337 PRO 337 418 418 PRO PRO A . n 
A 1 338 GLU 338 419 419 GLU GLU A . n 
A 1 339 ALA 339 420 420 ALA ALA A . n 
A 1 340 GLY 340 421 421 GLY GLY A . n 
A 1 341 THR 341 422 422 THR THR A . n 
A 1 342 TRP 342 423 423 TRP TRP A . n 
A 1 343 PHE 343 424 424 PHE PHE A . n 
A 1 344 GLN 344 425 425 GLN GLN A . n 
A 1 345 ALA 345 426 426 ALA ALA A . n 
A 1 346 TYR 346 427 427 TYR TYR A . n 
A 1 347 PHE 347 428 428 PHE PHE A . n 
A 1 348 GLN 348 429 429 GLN GLN A . n 
A 1 349 THR 349 430 430 THR THR A . n 
A 1 350 LEU 350 431 431 LEU LEU A . n 
A 1 351 VAL 351 432 432 VAL VAL A . n 
A 1 352 SER 352 433 433 SER SER A . n 
A 1 353 ALA 353 434 434 ALA ALA A . n 
A 1 354 ALA 354 435 435 ALA ALA A . n 
A 1 355 ASN 355 436 436 ASN ASN A . n 
A 1 356 PRO 356 437 437 PRO PRO A . n 
A 1 357 PRO 357 438 438 PRO PRO A . n 
A 1 358 LEU 358 439 439 LEU LEU A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 NAG 1   501  501 NAG NAG A . 
C 3 HOH 1   601  315 HOH HOH A . 
C 3 HOH 2   602  209 HOH HOH A . 
C 3 HOH 3   603  230 HOH HOH A . 
C 3 HOH 4   604  244 HOH HOH A . 
C 3 HOH 5   605  417 HOH HOH A . 
C 3 HOH 6   606  493 HOH HOH A . 
C 3 HOH 7   607  330 HOH HOH A . 
C 3 HOH 8   608  61  HOH HOH A . 
C 3 HOH 9   609  161 HOH HOH A . 
C 3 HOH 10  610  337 HOH HOH A . 
C 3 HOH 11  611  113 HOH HOH A . 
C 3 HOH 12  612  472 HOH HOH A . 
C 3 HOH 13  613  235 HOH HOH A . 
C 3 HOH 14  614  376 HOH HOH A . 
C 3 HOH 15  615  33  HOH HOH A . 
C 3 HOH 16  616  195 HOH HOH A . 
C 3 HOH 17  617  303 HOH HOH A . 
C 3 HOH 18  618  515 HOH HOH A . 
C 3 HOH 19  619  264 HOH HOH A . 
C 3 HOH 20  620  206 HOH HOH A . 
C 3 HOH 21  621  218 HOH HOH A . 
C 3 HOH 22  622  70  HOH HOH A . 
C 3 HOH 23  623  344 HOH HOH A . 
C 3 HOH 24  624  270 HOH HOH A . 
C 3 HOH 25  625  205 HOH HOH A . 
C 3 HOH 26  626  163 HOH HOH A . 
C 3 HOH 27  627  445 HOH HOH A . 
C 3 HOH 28  628  411 HOH HOH A . 
C 3 HOH 29  629  317 HOH HOH A . 
C 3 HOH 30  630  226 HOH HOH A . 
C 3 HOH 31  631  347 HOH HOH A . 
C 3 HOH 32  632  127 HOH HOH A . 
C 3 HOH 33  633  55  HOH HOH A . 
C 3 HOH 34  634  16  HOH HOH A . 
C 3 HOH 35  635  199 HOH HOH A . 
C 3 HOH 36  636  251 HOH HOH A . 
C 3 HOH 37  637  555 HOH HOH A . 
C 3 HOH 38  638  405 HOH HOH A . 
C 3 HOH 39  639  268 HOH HOH A . 
C 3 HOH 40  640  531 HOH HOH A . 
C 3 HOH 41  641  160 HOH HOH A . 
C 3 HOH 42  642  406 HOH HOH A . 
C 3 HOH 43  643  68  HOH HOH A . 
C 3 HOH 44  644  313 HOH HOH A . 
C 3 HOH 45  645  96  HOH HOH A . 
C 3 HOH 46  646  87  HOH HOH A . 
C 3 HOH 47  647  381 HOH HOH A . 
C 3 HOH 48  648  427 HOH HOH A . 
C 3 HOH 49  649  404 HOH HOH A . 
C 3 HOH 50  650  188 HOH HOH A . 
C 3 HOH 51  651  412 HOH HOH A . 
C 3 HOH 52  652  375 HOH HOH A . 
C 3 HOH 53  653  107 HOH HOH A . 
C 3 HOH 54  654  323 HOH HOH A . 
C 3 HOH 55  655  214 HOH HOH A . 
C 3 HOH 56  656  487 HOH HOH A . 
C 3 HOH 57  657  509 HOH HOH A . 
C 3 HOH 58  658  196 HOH HOH A . 
C 3 HOH 59  659  8   HOH HOH A . 
C 3 HOH 60  660  175 HOH HOH A . 
C 3 HOH 61  661  300 HOH HOH A . 
C 3 HOH 62  662  382 HOH HOH A . 
C 3 HOH 63  663  543 HOH HOH A . 
C 3 HOH 64  664  94  HOH HOH A . 
C 3 HOH 65  665  159 HOH HOH A . 
C 3 HOH 66  666  58  HOH HOH A . 
C 3 HOH 67  667  484 HOH HOH A . 
C 3 HOH 68  668  45  HOH HOH A . 
C 3 HOH 69  669  434 HOH HOH A . 
C 3 HOH 70  670  356 HOH HOH A . 
C 3 HOH 71  671  285 HOH HOH A . 
C 3 HOH 72  672  114 HOH HOH A . 
C 3 HOH 73  673  545 HOH HOH A . 
C 3 HOH 74  674  17  HOH HOH A . 
C 3 HOH 75  675  343 HOH HOH A . 
C 3 HOH 76  676  5   HOH HOH A . 
C 3 HOH 77  677  397 HOH HOH A . 
C 3 HOH 78  678  72  HOH HOH A . 
C 3 HOH 79  679  109 HOH HOH A . 
C 3 HOH 80  680  511 HOH HOH A . 
C 3 HOH 81  681  14  HOH HOH A . 
C 3 HOH 82  682  396 HOH HOH A . 
C 3 HOH 83  683  297 HOH HOH A . 
C 3 HOH 84  684  64  HOH HOH A . 
C 3 HOH 85  685  566 HOH HOH A . 
C 3 HOH 86  686  177 HOH HOH A . 
C 3 HOH 87  687  539 HOH HOH A . 
C 3 HOH 88  688  544 HOH HOH A . 
C 3 HOH 89  689  296 HOH HOH A . 
C 3 HOH 90  690  119 HOH HOH A . 
C 3 HOH 91  691  298 HOH HOH A . 
C 3 HOH 92  692  256 HOH HOH A . 
C 3 HOH 93  693  86  HOH HOH A . 
C 3 HOH 94  694  105 HOH HOH A . 
C 3 HOH 95  695  139 HOH HOH A . 
C 3 HOH 96  696  46  HOH HOH A . 
C 3 HOH 97  697  158 HOH HOH A . 
C 3 HOH 98  698  240 HOH HOH A . 
C 3 HOH 99  699  54  HOH HOH A . 
C 3 HOH 100 700  26  HOH HOH A . 
C 3 HOH 101 701  13  HOH HOH A . 
C 3 HOH 102 702  15  HOH HOH A . 
C 3 HOH 103 703  556 HOH HOH A . 
C 3 HOH 104 704  108 HOH HOH A . 
C 3 HOH 105 705  120 HOH HOH A . 
C 3 HOH 106 706  116 HOH HOH A . 
C 3 HOH 107 707  7   HOH HOH A . 
C 3 HOH 108 708  274 HOH HOH A . 
C 3 HOH 109 709  253 HOH HOH A . 
C 3 HOH 110 710  201 HOH HOH A . 
C 3 HOH 111 711  178 HOH HOH A . 
C 3 HOH 112 712  37  HOH HOH A . 
C 3 HOH 113 713  461 HOH HOH A . 
C 3 HOH 114 714  533 HOH HOH A . 
C 3 HOH 115 715  82  HOH HOH A . 
C 3 HOH 116 716  277 HOH HOH A . 
C 3 HOH 117 717  62  HOH HOH A . 
C 3 HOH 118 718  518 HOH HOH A . 
C 3 HOH 119 719  462 HOH HOH A . 
C 3 HOH 120 720  32  HOH HOH A . 
C 3 HOH 121 721  150 HOH HOH A . 
C 3 HOH 122 722  179 HOH HOH A . 
C 3 HOH 123 723  507 HOH HOH A . 
C 3 HOH 124 724  416 HOH HOH A . 
C 3 HOH 125 725  98  HOH HOH A . 
C 3 HOH 126 726  366 HOH HOH A . 
C 3 HOH 127 727  327 HOH HOH A . 
C 3 HOH 128 728  30  HOH HOH A . 
C 3 HOH 129 729  342 HOH HOH A . 
C 3 HOH 130 730  57  HOH HOH A . 
C 3 HOH 131 731  497 HOH HOH A . 
C 3 HOH 132 732  148 HOH HOH A . 
C 3 HOH 133 733  102 HOH HOH A . 
C 3 HOH 134 734  283 HOH HOH A . 
C 3 HOH 135 735  39  HOH HOH A . 
C 3 HOH 136 736  444 HOH HOH A . 
C 3 HOH 137 737  88  HOH HOH A . 
C 3 HOH 138 738  144 HOH HOH A . 
C 3 HOH 139 739  122 HOH HOH A . 
C 3 HOH 140 740  452 HOH HOH A . 
C 3 HOH 141 741  294 HOH HOH A . 
C 3 HOH 142 742  125 HOH HOH A . 
C 3 HOH 143 743  267 HOH HOH A . 
C 3 HOH 144 744  402 HOH HOH A . 
C 3 HOH 145 745  306 HOH HOH A . 
C 3 HOH 146 746  186 HOH HOH A . 
C 3 HOH 147 747  149 HOH HOH A . 
C 3 HOH 148 748  140 HOH HOH A . 
C 3 HOH 149 749  320 HOH HOH A . 
C 3 HOH 150 750  162 HOH HOH A . 
C 3 HOH 151 751  90  HOH HOH A . 
C 3 HOH 152 752  164 HOH HOH A . 
C 3 HOH 153 753  271 HOH HOH A . 
C 3 HOH 154 754  6   HOH HOH A . 
C 3 HOH 155 755  165 HOH HOH A . 
C 3 HOH 156 756  142 HOH HOH A . 
C 3 HOH 157 757  224 HOH HOH A . 
C 3 HOH 158 758  12  HOH HOH A . 
C 3 HOH 159 759  532 HOH HOH A . 
C 3 HOH 160 760  84  HOH HOH A . 
C 3 HOH 161 761  489 HOH HOH A . 
C 3 HOH 162 762  117 HOH HOH A . 
C 3 HOH 163 763  132 HOH HOH A . 
C 3 HOH 164 764  282 HOH HOH A . 
C 3 HOH 165 765  146 HOH HOH A . 
C 3 HOH 166 766  483 HOH HOH A . 
C 3 HOH 167 767  530 HOH HOH A . 
C 3 HOH 168 768  309 HOH HOH A . 
C 3 HOH 169 769  367 HOH HOH A . 
C 3 HOH 170 770  299 HOH HOH A . 
C 3 HOH 171 771  200 HOH HOH A . 
C 3 HOH 172 772  289 HOH HOH A . 
C 3 HOH 173 773  359 HOH HOH A . 
C 3 HOH 174 774  339 HOH HOH A . 
C 3 HOH 175 775  276 HOH HOH A . 
C 3 HOH 176 776  415 HOH HOH A . 
C 3 HOH 177 777  565 HOH HOH A . 
C 3 HOH 178 778  246 HOH HOH A . 
C 3 HOH 179 779  22  HOH HOH A . 
C 3 HOH 180 780  53  HOH HOH A . 
C 3 HOH 181 781  526 HOH HOH A . 
C 3 HOH 182 782  47  HOH HOH A . 
C 3 HOH 183 783  258 HOH HOH A . 
C 3 HOH 184 784  51  HOH HOH A . 
C 3 HOH 185 785  228 HOH HOH A . 
C 3 HOH 186 786  227 HOH HOH A . 
C 3 HOH 187 787  129 HOH HOH A . 
C 3 HOH 188 788  346 HOH HOH A . 
C 3 HOH 189 789  77  HOH HOH A . 
C 3 HOH 190 790  104 HOH HOH A . 
C 3 HOH 191 791  189 HOH HOH A . 
C 3 HOH 192 792  220 HOH HOH A . 
C 3 HOH 193 793  485 HOH HOH A . 
C 3 HOH 194 794  24  HOH HOH A . 
C 3 HOH 195 795  73  HOH HOH A . 
C 3 HOH 196 796  457 HOH HOH A . 
C 3 HOH 197 797  191 HOH HOH A . 
C 3 HOH 198 798  488 HOH HOH A . 
C 3 HOH 199 799  210 HOH HOH A . 
C 3 HOH 200 800  106 HOH HOH A . 
C 3 HOH 201 801  92  HOH HOH A . 
C 3 HOH 202 802  41  HOH HOH A . 
C 3 HOH 203 803  11  HOH HOH A . 
C 3 HOH 204 804  91  HOH HOH A . 
C 3 HOH 205 805  10  HOH HOH A . 
C 3 HOH 206 806  31  HOH HOH A . 
C 3 HOH 207 807  197 HOH HOH A . 
C 3 HOH 208 808  83  HOH HOH A . 
C 3 HOH 209 809  2   HOH HOH A . 
C 3 HOH 210 810  56  HOH HOH A . 
C 3 HOH 211 811  101 HOH HOH A . 
C 3 HOH 212 812  190 HOH HOH A . 
C 3 HOH 213 813  50  HOH HOH A . 
C 3 HOH 214 814  535 HOH HOH A . 
C 3 HOH 215 815  172 HOH HOH A . 
C 3 HOH 216 816  28  HOH HOH A . 
C 3 HOH 217 817  59  HOH HOH A . 
C 3 HOH 218 818  21  HOH HOH A . 
C 3 HOH 219 819  222 HOH HOH A . 
C 3 HOH 220 820  25  HOH HOH A . 
C 3 HOH 221 821  410 HOH HOH A . 
C 3 HOH 222 822  185 HOH HOH A . 
C 3 HOH 223 823  182 HOH HOH A . 
C 3 HOH 224 824  118 HOH HOH A . 
C 3 HOH 225 825  336 HOH HOH A . 
C 3 HOH 226 826  137 HOH HOH A . 
C 3 HOH 227 827  18  HOH HOH A . 
C 3 HOH 228 828  123 HOH HOH A . 
C 3 HOH 229 829  43  HOH HOH A . 
C 3 HOH 230 830  377 HOH HOH A . 
C 3 HOH 231 831  547 HOH HOH A . 
C 3 HOH 232 832  115 HOH HOH A . 
C 3 HOH 233 833  553 HOH HOH A . 
C 3 HOH 234 834  291 HOH HOH A . 
C 3 HOH 235 835  1   HOH HOH A . 
C 3 HOH 236 836  302 HOH HOH A . 
C 3 HOH 237 837  75  HOH HOH A . 
C 3 HOH 238 838  194 HOH HOH A . 
C 3 HOH 239 839  67  HOH HOH A . 
C 3 HOH 240 840  260 HOH HOH A . 
C 3 HOH 241 841  386 HOH HOH A . 
C 3 HOH 242 842  203 HOH HOH A . 
C 3 HOH 243 843  481 HOH HOH A . 
C 3 HOH 244 844  110 HOH HOH A . 
C 3 HOH 245 845  103 HOH HOH A . 
C 3 HOH 246 846  262 HOH HOH A . 
C 3 HOH 247 847  4   HOH HOH A . 
C 3 HOH 248 848  38  HOH HOH A . 
C 3 HOH 249 849  272 HOH HOH A . 
C 3 HOH 250 850  187 HOH HOH A . 
C 3 HOH 251 851  52  HOH HOH A . 
C 3 HOH 252 852  42  HOH HOH A . 
C 3 HOH 253 853  536 HOH HOH A . 
C 3 HOH 254 854  40  HOH HOH A . 
C 3 HOH 255 855  426 HOH HOH A . 
C 3 HOH 256 856  305 HOH HOH A . 
C 3 HOH 257 857  482 HOH HOH A . 
C 3 HOH 258 858  265 HOH HOH A . 
C 3 HOH 259 859  355 HOH HOH A . 
C 3 HOH 260 860  528 HOH HOH A . 
C 3 HOH 261 861  525 HOH HOH A . 
C 3 HOH 262 862  100 HOH HOH A . 
C 3 HOH 263 863  354 HOH HOH A . 
C 3 HOH 264 864  19  HOH HOH A . 
C 3 HOH 265 865  147 HOH HOH A . 
C 3 HOH 266 866  350 HOH HOH A . 
C 3 HOH 267 867  502 HOH HOH A . 
C 3 HOH 268 868  554 HOH HOH A . 
C 3 HOH 269 869  266 HOH HOH A . 
C 3 HOH 270 870  259 HOH HOH A . 
C 3 HOH 271 871  321 HOH HOH A . 
C 3 HOH 272 872  71  HOH HOH A . 
C 3 HOH 273 873  85  HOH HOH A . 
C 3 HOH 274 874  284 HOH HOH A . 
C 3 HOH 275 875  27  HOH HOH A . 
C 3 HOH 276 876  99  HOH HOH A . 
C 3 HOH 277 877  81  HOH HOH A . 
C 3 HOH 278 878  204 HOH HOH A . 
C 3 HOH 279 879  79  HOH HOH A . 
C 3 HOH 280 880  3   HOH HOH A . 
C 3 HOH 281 881  124 HOH HOH A . 
C 3 HOH 282 882  241 HOH HOH A . 
C 3 HOH 283 883  128 HOH HOH A . 
C 3 HOH 284 884  66  HOH HOH A . 
C 3 HOH 285 885  234 HOH HOH A . 
C 3 HOH 286 886  257 HOH HOH A . 
C 3 HOH 287 887  143 HOH HOH A . 
C 3 HOH 288 888  23  HOH HOH A . 
C 3 HOH 289 889  216 HOH HOH A . 
C 3 HOH 290 890  247 HOH HOH A . 
C 3 HOH 291 891  443 HOH HOH A . 
C 3 HOH 292 892  74  HOH HOH A . 
C 3 HOH 293 893  333 HOH HOH A . 
C 3 HOH 294 894  348 HOH HOH A . 
C 3 HOH 295 895  542 HOH HOH A . 
C 3 HOH 296 896  65  HOH HOH A . 
C 3 HOH 297 897  449 HOH HOH A . 
C 3 HOH 298 898  97  HOH HOH A . 
C 3 HOH 299 899  459 HOH HOH A . 
C 3 HOH 300 900  183 HOH HOH A . 
C 3 HOH 301 901  369 HOH HOH A . 
C 3 HOH 302 902  80  HOH HOH A . 
C 3 HOH 303 903  138 HOH HOH A . 
C 3 HOH 304 904  49  HOH HOH A . 
C 3 HOH 305 905  480 HOH HOH A . 
C 3 HOH 306 906  254 HOH HOH A . 
C 3 HOH 307 907  35  HOH HOH A . 
C 3 HOH 308 908  293 HOH HOH A . 
C 3 HOH 309 909  237 HOH HOH A . 
C 3 HOH 310 910  60  HOH HOH A . 
C 3 HOH 311 911  78  HOH HOH A . 
C 3 HOH 312 912  364 HOH HOH A . 
C 3 HOH 313 913  126 HOH HOH A . 
C 3 HOH 314 914  44  HOH HOH A . 
C 3 HOH 315 915  171 HOH HOH A . 
C 3 HOH 316 916  331 HOH HOH A . 
C 3 HOH 317 917  255 HOH HOH A . 
C 3 HOH 318 918  217 HOH HOH A . 
C 3 HOH 319 919  219 HOH HOH A . 
C 3 HOH 320 920  295 HOH HOH A . 
C 3 HOH 321 921  193 HOH HOH A . 
C 3 HOH 322 922  492 HOH HOH A . 
C 3 HOH 323 923  48  HOH HOH A . 
C 3 HOH 324 924  341 HOH HOH A . 
C 3 HOH 325 925  548 HOH HOH A . 
C 3 HOH 326 926  145 HOH HOH A . 
C 3 HOH 327 927  202 HOH HOH A . 
C 3 HOH 328 928  340 HOH HOH A . 
C 3 HOH 329 929  563 HOH HOH A . 
C 3 HOH 330 930  310 HOH HOH A . 
C 3 HOH 331 931  133 HOH HOH A . 
C 3 HOH 332 932  498 HOH HOH A . 
C 3 HOH 333 933  454 HOH HOH A . 
C 3 HOH 334 934  156 HOH HOH A . 
C 3 HOH 335 935  372 HOH HOH A . 
C 3 HOH 336 936  400 HOH HOH A . 
C 3 HOH 337 937  490 HOH HOH A . 
C 3 HOH 338 938  467 HOH HOH A . 
C 3 HOH 339 939  236 HOH HOH A . 
C 3 HOH 340 940  312 HOH HOH A . 
C 3 HOH 341 941  314 HOH HOH A . 
C 3 HOH 342 942  112 HOH HOH A . 
C 3 HOH 343 943  308 HOH HOH A . 
C 3 HOH 344 944  429 HOH HOH A . 
C 3 HOH 345 945  325 HOH HOH A . 
C 3 HOH 346 946  131 HOH HOH A . 
C 3 HOH 347 947  368 HOH HOH A . 
C 3 HOH 348 948  261 HOH HOH A . 
C 3 HOH 349 949  335 HOH HOH A . 
C 3 HOH 350 950  307 HOH HOH A . 
C 3 HOH 351 951  151 HOH HOH A . 
C 3 HOH 352 952  451 HOH HOH A . 
C 3 HOH 353 953  316 HOH HOH A . 
C 3 HOH 354 954  29  HOH HOH A . 
C 3 HOH 355 955  34  HOH HOH A . 
C 3 HOH 356 956  135 HOH HOH A . 
C 3 HOH 357 957  468 HOH HOH A . 
C 3 HOH 358 958  513 HOH HOH A . 
C 3 HOH 359 959  20  HOH HOH A . 
C 3 HOH 360 960  352 HOH HOH A . 
C 3 HOH 361 961  252 HOH HOH A . 
C 3 HOH 362 962  89  HOH HOH A . 
C 3 HOH 363 963  392 HOH HOH A . 
C 3 HOH 364 964  538 HOH HOH A . 
C 3 HOH 365 965  505 HOH HOH A . 
C 3 HOH 366 966  9   HOH HOH A . 
C 3 HOH 367 967  371 HOH HOH A . 
C 3 HOH 368 968  353 HOH HOH A . 
C 3 HOH 369 969  551 HOH HOH A . 
C 3 HOH 370 970  69  HOH HOH A . 
C 3 HOH 371 971  130 HOH HOH A . 
C 3 HOH 372 972  229 HOH HOH A . 
C 3 HOH 373 973  447 HOH HOH A . 
C 3 HOH 374 974  198 HOH HOH A . 
C 3 HOH 375 975  383 HOH HOH A . 
C 3 HOH 376 976  470 HOH HOH A . 
C 3 HOH 377 977  537 HOH HOH A . 
C 3 HOH 378 978  550 HOH HOH A . 
C 3 HOH 379 979  399 HOH HOH A . 
C 3 HOH 380 980  508 HOH HOH A . 
C 3 HOH 381 981  428 HOH HOH A . 
C 3 HOH 382 982  414 HOH HOH A . 
C 3 HOH 383 983  324 HOH HOH A . 
C 3 HOH 384 984  456 HOH HOH A . 
C 3 HOH 385 985  479 HOH HOH A . 
C 3 HOH 386 986  389 HOH HOH A . 
C 3 HOH 387 987  378 HOH HOH A . 
C 3 HOH 388 988  495 HOH HOH A . 
C 3 HOH 389 989  527 HOH HOH A . 
C 3 HOH 390 990  173 HOH HOH A . 
C 3 HOH 391 991  334 HOH HOH A . 
C 3 HOH 392 992  363 HOH HOH A . 
C 3 HOH 393 993  349 HOH HOH A . 
C 3 HOH 394 994  424 HOH HOH A . 
C 3 HOH 395 995  453 HOH HOH A . 
C 3 HOH 396 996  269 HOH HOH A . 
C 3 HOH 397 997  409 HOH HOH A . 
C 3 HOH 398 998  280 HOH HOH A . 
C 3 HOH 399 999  207 HOH HOH A . 
C 3 HOH 400 1000 329 HOH HOH A . 
C 3 HOH 401 1001 332 HOH HOH A . 
C 3 HOH 402 1002 166 HOH HOH A . 
C 3 HOH 403 1003 111 HOH HOH A . 
C 3 HOH 404 1004 521 HOH HOH A . 
C 3 HOH 405 1005 95  HOH HOH A . 
C 3 HOH 406 1006 63  HOH HOH A . 
C 3 HOH 407 1007 561 HOH HOH A . 
C 3 HOH 408 1008 358 HOH HOH A . 
C 3 HOH 409 1009 442 HOH HOH A . 
C 3 HOH 410 1010 562 HOH HOH A . 
C 3 HOH 411 1011 441 HOH HOH A . 
C 3 HOH 412 1012 559 HOH HOH A . 
C 3 HOH 413 1013 170 HOH HOH A . 
C 3 HOH 414 1014 225 HOH HOH A . 
C 3 HOH 415 1015 212 HOH HOH A . 
C 3 HOH 416 1016 431 HOH HOH A . 
C 3 HOH 417 1017 215 HOH HOH A . 
C 3 HOH 418 1018 437 HOH HOH A . 
C 3 HOH 419 1019 560 HOH HOH A . 
C 3 HOH 420 1020 558 HOH HOH A . 
C 3 HOH 421 1021 176 HOH HOH A . 
C 3 HOH 422 1022 168 HOH HOH A . 
C 3 HOH 423 1023 292 HOH HOH A . 
C 3 HOH 424 1024 413 HOH HOH A . 
C 3 HOH 425 1025 499 HOH HOH A . 
C 3 HOH 426 1026 465 HOH HOH A . 
C 3 HOH 427 1027 290 HOH HOH A . 
C 3 HOH 428 1028 476 HOH HOH A . 
C 3 HOH 429 1029 420 HOH HOH A . 
C 3 HOH 430 1030 281 HOH HOH A . 
C 3 HOH 431 1031 450 HOH HOH A . 
C 3 HOH 432 1032 121 HOH HOH A . 
C 3 HOH 433 1033 403 HOH HOH A . 
C 3 HOH 434 1034 516 HOH HOH A . 
C 3 HOH 435 1035 471 HOH HOH A . 
C 3 HOH 436 1036 401 HOH HOH A . 
C 3 HOH 437 1037 418 HOH HOH A . 
C 3 HOH 438 1038 435 HOH HOH A . 
C 3 HOH 439 1039 155 HOH HOH A . 
C 3 HOH 440 1040 504 HOH HOH A . 
C 3 HOH 441 1041 278 HOH HOH A . 
C 3 HOH 442 1042 398 HOH HOH A . 
C 3 HOH 443 1043 524 HOH HOH A . 
C 3 HOH 444 1044 546 HOH HOH A . 
C 3 HOH 445 1045 466 HOH HOH A . 
C 3 HOH 446 1046 478 HOH HOH A . 
C 3 HOH 447 1047 491 HOH HOH A . 
C 3 HOH 448 1048 152 HOH HOH A . 
C 3 HOH 449 1049 263 HOH HOH A . 
C 3 HOH 450 1050 174 HOH HOH A . 
C 3 HOH 451 1051 379 HOH HOH A . 
C 3 HOH 452 1052 473 HOH HOH A . 
C 3 HOH 453 1053 430 HOH HOH A . 
C 3 HOH 454 1054 362 HOH HOH A . 
C 3 HOH 455 1055 318 HOH HOH A . 
C 3 HOH 456 1056 448 HOH HOH A . 
C 3 HOH 457 1057 301 HOH HOH A . 
C 3 HOH 458 1058 157 HOH HOH A . 
C 3 HOH 459 1059 286 HOH HOH A . 
C 3 HOH 460 1060 391 HOH HOH A . 
C 3 HOH 461 1061 388 HOH HOH A . 
C 3 HOH 462 1062 387 HOH HOH A . 
C 3 HOH 463 1063 549 HOH HOH A . 
C 3 HOH 464 1064 322 HOH HOH A . 
C 3 HOH 465 1065 394 HOH HOH A . 
C 3 HOH 466 1066 153 HOH HOH A . 
C 3 HOH 467 1067 385 HOH HOH A . 
C 3 HOH 468 1068 93  HOH HOH A . 
C 3 HOH 469 1069 136 HOH HOH A . 
C 3 HOH 470 1070 475 HOH HOH A . 
C 3 HOH 471 1071 221 HOH HOH A . 
C 3 HOH 472 1072 567 HOH HOH A . 
C 3 HOH 473 1073 455 HOH HOH A . 
C 3 HOH 474 1074 279 HOH HOH A . 
C 3 HOH 475 1075 408 HOH HOH A . 
C 3 HOH 476 1076 249 HOH HOH A . 
C 3 HOH 477 1077 520 HOH HOH A . 
C 3 HOH 478 1078 243 HOH HOH A . 
C 3 HOH 479 1079 464 HOH HOH A . 
C 3 HOH 480 1080 233 HOH HOH A . 
C 3 HOH 481 1081 248 HOH HOH A . 
C 3 HOH 482 1082 463 HOH HOH A . 
C 3 HOH 483 1083 245 HOH HOH A . 
C 3 HOH 484 1084 503 HOH HOH A . 
C 3 HOH 485 1085 446 HOH HOH A . 
C 3 HOH 486 1086 141 HOH HOH A . 
C 3 HOH 487 1087 223 HOH HOH A . 
C 3 HOH 488 1088 361 HOH HOH A . 
C 3 HOH 489 1089 419 HOH HOH A . 
C 3 HOH 490 1090 180 HOH HOH A . 
C 3 HOH 491 1091 458 HOH HOH A . 
C 3 HOH 492 1092 438 HOH HOH A . 
C 3 HOH 493 1093 425 HOH HOH A . 
C 3 HOH 494 1094 36  HOH HOH A . 
C 3 HOH 495 1095 523 HOH HOH A . 
C 3 HOH 496 1096 384 HOH HOH A . 
C 3 HOH 497 1097 232 HOH HOH A . 
C 3 HOH 498 1098 211 HOH HOH A . 
C 3 HOH 499 1099 311 HOH HOH A . 
C 3 HOH 500 1100 374 HOH HOH A . 
C 3 HOH 501 1101 184 HOH HOH A . 
C 3 HOH 502 1102 213 HOH HOH A . 
C 3 HOH 503 1103 288 HOH HOH A . 
C 3 HOH 504 1104 514 HOH HOH A . 
C 3 HOH 505 1105 273 HOH HOH A . 
C 3 HOH 506 1106 287 HOH HOH A . 
C 3 HOH 507 1107 345 HOH HOH A . 
C 3 HOH 508 1108 486 HOH HOH A . 
C 3 HOH 509 1109 496 HOH HOH A . 
C 3 HOH 510 1110 365 HOH HOH A . 
C 3 HOH 511 1111 557 HOH HOH A . 
C 3 HOH 512 1112 208 HOH HOH A . 
C 3 HOH 513 1113 239 HOH HOH A . 
C 3 HOH 514 1114 380 HOH HOH A . 
C 3 HOH 515 1115 534 HOH HOH A . 
C 3 HOH 516 1116 338 HOH HOH A . 
C 3 HOH 517 1117 167 HOH HOH A . 
C 3 HOH 518 1118 519 HOH HOH A . 
C 3 HOH 519 1119 460 HOH HOH A . 
C 3 HOH 520 1120 407 HOH HOH A . 
C 3 HOH 521 1121 326 HOH HOH A . 
C 3 HOH 522 1122 540 HOH HOH A . 
C 3 HOH 523 1123 304 HOH HOH A . 
C 3 HOH 524 1124 494 HOH HOH A . 
C 3 HOH 525 1125 474 HOH HOH A . 
C 3 HOH 526 1126 433 HOH HOH A . 
C 3 HOH 527 1127 501 HOH HOH A . 
C 3 HOH 528 1128 360 HOH HOH A . 
C 3 HOH 529 1129 568 HOH HOH A . 
C 3 HOH 530 1130 395 HOH HOH A . 
C 3 HOH 531 1131 564 HOH HOH A . 
C 3 HOH 532 1132 390 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8X04 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     54.813 
_cell.length_a_esd                 ? 
_cell.length_b                     67.825 
_cell.length_b_esd                 ? 
_cell.length_c                     88.258 
_cell.length_c_esd                 ? 
_cell.volume                       328116.036 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8X04 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8X04 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.14 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.56 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG 4000, sodium acetate, sodium chloride' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     95 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 S 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-5A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-5A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          10.17 
_reflns.entry_id                                       8X04 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              0.97 
_reflns.d_resolution_low                               46.56 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     190992 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          37.1 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.028 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    0.97 
_reflns_shell.d_res_low                                     0.99 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.5 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             8866 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               8.3 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          93.6 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.648 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               12.27 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8X04 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            0.97 
_refine.ls_d_res_low                             38.39 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     190896 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  188896 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.28 
_refine.ls_percent_reflns_R_free                 1.05 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1612 
_refine.ls_R_factor_R_free                       0.1792 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1612 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 16.2991 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.0757 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       0.97 
_refine_hist.d_res_low                        38.39 
_refine_hist.number_atoms_solvent             532 
_refine_hist.number_atoms_total               3253 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2707 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         14 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0050 ? 3911 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8855 ? 5421 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0828 ? 603  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0067 ? 734  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.7380 ? 568  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 0.97 0.99  . . 134 12687 93.42 . . . . 0.2183 . . . . . . . . . . . 0.2508 
'X-RAY DIFFRACTION' 0.99 1.02  . . 137 12881 94.83 . . . . 0.1950 . . . . . . . . . . . 0.1996 
'X-RAY DIFFRACTION' 1.02 1.05  . . 138 13098 96.05 . . . . 0.1821 . . . . . . . . . . . 0.1791 
'X-RAY DIFFRACTION' 1.05 1.09  . . 139 13181 97.02 . . . . 0.1647 . . . . . . . . . . . 0.1621 
'X-RAY DIFFRACTION' 1.09 1.12  . . 142 13334 97.69 . . . . 0.1569 . . . . . . . . . . . 0.1532 
'X-RAY DIFFRACTION' 1.12 1.17  . . 142 13473 98.66 . . . . 0.1523 . . . . . . . . . . . 0.1648 
'X-RAY DIFFRACTION' 1.17 1.22  . . 144 13538 99.30 . . . . 0.1545 . . . . . . . . . . . 0.1466 
'X-RAY DIFFRACTION' 1.22 1.29  . . 144 13567 99.33 . . . . 0.1525 . . . . . . . . . . . 0.1633 
'X-RAY DIFFRACTION' 1.29 1.37  . . 144 13685 99.68 . . . . 0.1592 . . . . . . . . . . . 0.1835 
'X-RAY DIFFRACTION' 1.37 1.47  . . 146 13687 99.87 . . . . 0.1563 . . . . . . . . . . . 0.1693 
'X-RAY DIFFRACTION' 1.47 1.62  . . 145 13736 99.96 . . . . 0.1528 . . . . . . . . . . . 0.1746 
'X-RAY DIFFRACTION' 1.62 1.86  . . 147 13838 99.99 . . . . 0.1615 . . . . . . . . . . . 0.1903 
'X-RAY DIFFRACTION' 1.86 2.34  . . 147 13890 99.97 . . . . 0.1668 . . . . . . . . . . . 0.1769 
'X-RAY DIFFRACTION' 2.34 38.39 . . 151 14301 99.94 . . . . 0.1583 . . . . . . . . . . . 0.1818 
# 
_struct.entry_id                     8X04 
_struct.title                        
;X-Ray crystal structure of glycoside hydrolase family 6 cellobiohydrolase from Phanerochaete chrysosporium PcCel6A C240S/C393S/D394A
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8X04 
_struct_keywords.text            'Glycoside hydrolase family 6, cellobiohydrolase, cellulase, catalytic domain, mutant, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    H3K419_PHACH 
_struct_ref.pdbx_db_accession          H3K419 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLACV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGECDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_struct_ref.pdbx_align_begin           82 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8X04 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 358 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             H3K419 
_struct_ref_seq.db_align_beg                  82 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  439 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       82 
_struct_ref_seq.pdbx_auth_seq_align_end       439 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8X04 SER A 159 ? UNP H3K419 CYS 240 'engineered mutation' 240 1 
1 8X04 SER A 312 ? UNP H3K419 CYS 393 'engineered mutation' 393 2 
1 8X04 ALA A 313 ? UNP H3K419 ASP 394 'engineered mutation' 394 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                
;Software (PISA) determined protein interfaces have not revealed any specific interactions that could form stable quaternary structures.
;
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 14  ? ILE A 28  ? SER A 95  ILE A 109 1 ? 15 
HELX_P HELX_P2  AA2 ASP A 30  ? VAL A 40  ? ASP A 111 VAL A 121 1 ? 11 
HELX_P HELX_P3  AA3 ALA A 41  ? ILE A 43  ? ALA A 122 ILE A 124 5 ? 3  
HELX_P HELX_P4  AA4 SER A 51  ? ALA A 53  ? SER A 132 ALA A 134 5 ? 3  
HELX_P HELX_P5  AA5 LYS A 54  ? GLY A 73  ? LYS A 135 GLY A 154 1 ? 20 
HELX_P HELX_P6  AA6 ASN A 104 ? GLN A 121 ? ASN A 185 GLN A 202 1 ? 18 
HELX_P HELX_P7  AA7 SER A 136 ? ASN A 143 ? SER A 217 ASN A 224 1 ? 8  
HELX_P HELX_P8  AA8 VAL A 146 ? LYS A 169 ? VAL A 227 LYS A 250 1 ? 24 
HELX_P HELX_P9  AA9 TRP A 186 ? ALA A 204 ? TRP A 267 ALA A 285 1 ? 19 
HELX_P HELX_P10 AB1 ASP A 229 ? GLN A 233 ? ASP A 310 GLN A 314 5 ? 5  
HELX_P HELX_P11 AB2 ASP A 239 ? ALA A 254 ? ASP A 320 ALA A 335 1 ? 16 
HELX_P HELX_P12 AB3 ASP A 324 ? LEU A 329 ? ASP A 405 LEU A 410 5 ? 6  
HELX_P HELX_P13 AB4 PHE A 343 ? ALA A 353 ? PHE A 424 ALA A 434 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 90  SG  ? ? ? 1_555 A CYS 149 SG ? ? A CYS 171 A CYS 230 1_555 ? ? ? ? ? ? ? 2.060 ? ?               
disulf2 disulf ?   ? A CYS 280 SG  A ? ? 1_555 A CYS 327 SG A ? A CYS 361 A CYS 408 1_555 ? ? ? ? ? ? ? 2.056 ? ?               
disulf3 disulf ?   ? A CYS 280 SG  B ? ? 1_555 A CYS 327 SG B ? A CYS 361 A CYS 408 1_555 ? ? ? ? ? ? ? 2.038 ? ?               
covale1 covale one ? A ASN 317 ND2 ? ? ? 1_555 B NAG .   C1 ? ? A ASN 398 A NAG 501 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG B .   ? ASN A 317 ? NAG A 501 ? 1_555 ASN A 398 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 CYS A 90  ? CYS A 149 ? CYS A 171 ? 1_555 CYS A 230 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3 CYS A 280 A CYS A 327 A CYS A 361 ? 1_555 CYS A 408 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4 CYS A 280 B CYS A 327 B CYS A 361 ? 1_555 CYS A 408 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLN 334 A . ? GLN 415 A PRO 335 A ? PRO 416 A 1 -3.44 
2 GLN 334 A . ? GLN 415 A PRO 335 A ? PRO 416 A 1 0.34  
3 ASN 355 A . ? ASN 436 A PRO 356 A ? PRO 437 A 1 1.00  
4 ASN 355 A . ? ASN 436 A PRO 356 A ? PRO 437 A 1 6.43  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA2 3 4 ? parallel 
AA2 4 5 ? parallel 
AA2 5 6 ? parallel 
AA2 6 7 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 10  ? ILE A 11  ? GLN A 91  ILE A 92  
AA1 2 GLN A 76  ? ILE A 82  ? GLN A 157 ILE A 163 
AA1 3 THR A 47  ? LEU A 49  ? THR A 128 LEU A 130 
AA2 1 GLN A 10  ? ILE A 11  ? GLN A 91  ILE A 92  
AA2 2 GLN A 76  ? ILE A 82  ? GLN A 157 ILE A 163 
AA2 3 VAL A 126 ? ILE A 132 ? VAL A 207 ILE A 213 
AA2 4 TYR A 173 ? ASP A 177 ? TYR A 254 ASP A 258 
AA2 5 ILE A 210 ? THR A 215 ? ILE A 291 THR A 296 
AA2 6 THR A 259 ? ASP A 263 ? THR A 340 ASP A 344 
AA2 7 ILE A 300 ? VAL A 304 ? ILE A 381 VAL A 385 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 10  ? N GLN A 91  O LEU A 77  ? O LEU A 158 
AA1 2 3 O VAL A 81  ? O VAL A 162 N LEU A 49  ? N LEU A 130 
AA2 1 2 N GLN A 10  ? N GLN A 91  O LEU A 77  ? O LEU A 158 
AA2 2 3 N ILE A 82  ? N ILE A 163 O VAL A 131 ? O VAL A 212 
AA2 3 4 N ALA A 130 ? N ALA A 211 O TYR A 173 ? O TYR A 254 
AA2 4 5 N MET A 176 ? N MET A 257 O ALA A 214 ? O ALA A 295 
AA2 5 6 N THR A 215 ? N THR A 296 O ASP A 263 ? O ASP A 344 
AA2 6 7 N VAL A 262 ? N VAL A 343 O VAL A 304 ? O VAL A 385 
# 
_pdbx_entry_details.entry_id                   8X04 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 TYR A 164 ? ? -151.65 69.48   
2  1 ASP A 165 ? ? -149.13 32.51   
3  1 ASN A 184 ? A -119.84 65.12   
4  1 GLU A 214 ? ? 52.21   74.25   
5  1 ASP A 216 ? B 83.07   -24.60  
6  1 SER A 217 ? ? -121.51 -82.45  
7  1 SER A 217 ? ? -64.19  -82.45  
8  1 TRP A 264 ? ? -111.51 -71.88  
9  1 ASN A 300 ? ? -112.61 -164.68 
10 1 TRP A 360 ? B -152.87 -21.70  
11 1 SER A 406 ? B -63.75  0.28    
12 1 ASP A 412 ? ? -68.04  6.14    
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
NAG C1   C N R 250 
NAG C2   C N R 251 
NAG C3   C N R 252 
NAG C4   C N S 253 
NAG C5   C N R 254 
NAG C6   C N N 255 
NAG C7   C N N 256 
NAG C8   C N N 257 
NAG N2   N N N 258 
NAG O1   O N N 259 
NAG O3   O N N 260 
NAG O4   O N N 261 
NAG O5   O N N 262 
NAG O6   O N N 263 
NAG O7   O N N 264 
NAG H1   H N N 265 
NAG H2   H N N 266 
NAG H3   H N N 267 
NAG H4   H N N 268 
NAG H5   H N N 269 
NAG H61  H N N 270 
NAG H62  H N N 271 
NAG H81  H N N 272 
NAG H82  H N N 273 
NAG H83  H N N 274 
NAG HN2  H N N 275 
NAG HO1  H N N 276 
NAG HO3  H N N 277 
NAG HO4  H N N 278 
NAG HO6  H N N 279 
PHE N    N N N 280 
PHE CA   C N S 281 
PHE C    C N N 282 
PHE O    O N N 283 
PHE CB   C N N 284 
PHE CG   C Y N 285 
PHE CD1  C Y N 286 
PHE CD2  C Y N 287 
PHE CE1  C Y N 288 
PHE CE2  C Y N 289 
PHE CZ   C Y N 290 
PHE OXT  O N N 291 
PHE H    H N N 292 
PHE H2   H N N 293 
PHE HA   H N N 294 
PHE HB2  H N N 295 
PHE HB3  H N N 296 
PHE HD1  H N N 297 
PHE HD2  H N N 298 
PHE HE1  H N N 299 
PHE HE2  H N N 300 
PHE HZ   H N N 301 
PHE HXT  H N N 302 
PRO N    N N N 303 
PRO CA   C N S 304 
PRO C    C N N 305 
PRO O    O N N 306 
PRO CB   C N N 307 
PRO CG   C N N 308 
PRO CD   C N N 309 
PRO OXT  O N N 310 
PRO H    H N N 311 
PRO HA   H N N 312 
PRO HB2  H N N 313 
PRO HB3  H N N 314 
PRO HG2  H N N 315 
PRO HG3  H N N 316 
PRO HD2  H N N 317 
PRO HD3  H N N 318 
PRO HXT  H N N 319 
SER N    N N N 320 
SER CA   C N S 321 
SER C    C N N 322 
SER O    O N N 323 
SER CB   C N N 324 
SER OG   O N N 325 
SER OXT  O N N 326 
SER H    H N N 327 
SER H2   H N N 328 
SER HA   H N N 329 
SER HB2  H N N 330 
SER HB3  H N N 331 
SER HG   H N N 332 
SER HXT  H N N 333 
THR N    N N N 334 
THR CA   C N S 335 
THR C    C N N 336 
THR O    O N N 337 
THR CB   C N R 338 
THR OG1  O N N 339 
THR CG2  C N N 340 
THR OXT  O N N 341 
THR H    H N N 342 
THR H2   H N N 343 
THR HA   H N N 344 
THR HB   H N N 345 
THR HG1  H N N 346 
THR HG21 H N N 347 
THR HG22 H N N 348 
THR HG23 H N N 349 
THR HXT  H N N 350 
TRP N    N N N 351 
TRP CA   C N S 352 
TRP C    C N N 353 
TRP O    O N N 354 
TRP CB   C N N 355 
TRP CG   C Y N 356 
TRP CD1  C Y N 357 
TRP CD2  C Y N 358 
TRP NE1  N Y N 359 
TRP CE2  C Y N 360 
TRP CE3  C Y N 361 
TRP CZ2  C Y N 362 
TRP CZ3  C Y N 363 
TRP CH2  C Y N 364 
TRP OXT  O N N 365 
TRP H    H N N 366 
TRP H2   H N N 367 
TRP HA   H N N 368 
TRP HB2  H N N 369 
TRP HB3  H N N 370 
TRP HD1  H N N 371 
TRP HE1  H N N 372 
TRP HE3  H N N 373 
TRP HZ2  H N N 374 
TRP HZ3  H N N 375 
TRP HH2  H N N 376 
TRP HXT  H N N 377 
TYR N    N N N 378 
TYR CA   C N S 379 
TYR C    C N N 380 
TYR O    O N N 381 
TYR CB   C N N 382 
TYR CG   C Y N 383 
TYR CD1  C Y N 384 
TYR CD2  C Y N 385 
TYR CE1  C Y N 386 
TYR CE2  C Y N 387 
TYR CZ   C Y N 388 
TYR OH   O N N 389 
TYR OXT  O N N 390 
TYR H    H N N 391 
TYR H2   H N N 392 
TYR HA   H N N 393 
TYR HB2  H N N 394 
TYR HB3  H N N 395 
TYR HD1  H N N 396 
TYR HD2  H N N 397 
TYR HE1  H N N 398 
TYR HE2  H N N 399 
TYR HH   H N N 400 
TYR HXT  H N N 401 
VAL N    N N N 402 
VAL CA   C N S 403 
VAL C    C N N 404 
VAL O    O N N 405 
VAL CB   C N N 406 
VAL CG1  C N N 407 
VAL CG2  C N N 408 
VAL OXT  O N N 409 
VAL H    H N N 410 
VAL H2   H N N 411 
VAL HA   H N N 412 
VAL HB   H N N 413 
VAL HG11 H N N 414 
VAL HG12 H N N 415 
VAL HG13 H N N 416 
VAL HG21 H N N 417 
VAL HG22 H N N 418 
VAL HG23 H N N 419 
VAL HXT  H N N 420 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NAG C1  C2   sing N N 237 
NAG C1  O1   sing N N 238 
NAG C1  O5   sing N N 239 
NAG C1  H1   sing N N 240 
NAG C2  C3   sing N N 241 
NAG C2  N2   sing N N 242 
NAG C2  H2   sing N N 243 
NAG C3  C4   sing N N 244 
NAG C3  O3   sing N N 245 
NAG C3  H3   sing N N 246 
NAG C4  C5   sing N N 247 
NAG C4  O4   sing N N 248 
NAG C4  H4   sing N N 249 
NAG C5  C6   sing N N 250 
NAG C5  O5   sing N N 251 
NAG C5  H5   sing N N 252 
NAG C6  O6   sing N N 253 
NAG C6  H61  sing N N 254 
NAG C6  H62  sing N N 255 
NAG C7  C8   sing N N 256 
NAG C7  N2   sing N N 257 
NAG C7  O7   doub N N 258 
NAG C8  H81  sing N N 259 
NAG C8  H82  sing N N 260 
NAG C8  H83  sing N N 261 
NAG N2  HN2  sing N N 262 
NAG O1  HO1  sing N N 263 
NAG O3  HO3  sing N N 264 
NAG O4  HO4  sing N N 265 
NAG O6  HO6  sing N N 266 
PHE N   CA   sing N N 267 
PHE N   H    sing N N 268 
PHE N   H2   sing N N 269 
PHE CA  C    sing N N 270 
PHE CA  CB   sing N N 271 
PHE CA  HA   sing N N 272 
PHE C   O    doub N N 273 
PHE C   OXT  sing N N 274 
PHE CB  CG   sing N N 275 
PHE CB  HB2  sing N N 276 
PHE CB  HB3  sing N N 277 
PHE CG  CD1  doub Y N 278 
PHE CG  CD2  sing Y N 279 
PHE CD1 CE1  sing Y N 280 
PHE CD1 HD1  sing N N 281 
PHE CD2 CE2  doub Y N 282 
PHE CD2 HD2  sing N N 283 
PHE CE1 CZ   doub Y N 284 
PHE CE1 HE1  sing N N 285 
PHE CE2 CZ   sing Y N 286 
PHE CE2 HE2  sing N N 287 
PHE CZ  HZ   sing N N 288 
PHE OXT HXT  sing N N 289 
PRO N   CA   sing N N 290 
PRO N   CD   sing N N 291 
PRO N   H    sing N N 292 
PRO CA  C    sing N N 293 
PRO CA  CB   sing N N 294 
PRO CA  HA   sing N N 295 
PRO C   O    doub N N 296 
PRO C   OXT  sing N N 297 
PRO CB  CG   sing N N 298 
PRO CB  HB2  sing N N 299 
PRO CB  HB3  sing N N 300 
PRO CG  CD   sing N N 301 
PRO CG  HG2  sing N N 302 
PRO CG  HG3  sing N N 303 
PRO CD  HD2  sing N N 304 
PRO CD  HD3  sing N N 305 
PRO OXT HXT  sing N N 306 
SER N   CA   sing N N 307 
SER N   H    sing N N 308 
SER N   H2   sing N N 309 
SER CA  C    sing N N 310 
SER CA  CB   sing N N 311 
SER CA  HA   sing N N 312 
SER C   O    doub N N 313 
SER C   OXT  sing N N 314 
SER CB  OG   sing N N 315 
SER CB  HB2  sing N N 316 
SER CB  HB3  sing N N 317 
SER OG  HG   sing N N 318 
SER OXT HXT  sing N N 319 
THR N   CA   sing N N 320 
THR N   H    sing N N 321 
THR N   H2   sing N N 322 
THR CA  C    sing N N 323 
THR CA  CB   sing N N 324 
THR CA  HA   sing N N 325 
THR C   O    doub N N 326 
THR C   OXT  sing N N 327 
THR CB  OG1  sing N N 328 
THR CB  CG2  sing N N 329 
THR CB  HB   sing N N 330 
THR OG1 HG1  sing N N 331 
THR CG2 HG21 sing N N 332 
THR CG2 HG22 sing N N 333 
THR CG2 HG23 sing N N 334 
THR OXT HXT  sing N N 335 
TRP N   CA   sing N N 336 
TRP N   H    sing N N 337 
TRP N   H2   sing N N 338 
TRP CA  C    sing N N 339 
TRP CA  CB   sing N N 340 
TRP CA  HA   sing N N 341 
TRP C   O    doub N N 342 
TRP C   OXT  sing N N 343 
TRP CB  CG   sing N N 344 
TRP CB  HB2  sing N N 345 
TRP CB  HB3  sing N N 346 
TRP CG  CD1  doub Y N 347 
TRP CG  CD2  sing Y N 348 
TRP CD1 NE1  sing Y N 349 
TRP CD1 HD1  sing N N 350 
TRP CD2 CE2  doub Y N 351 
TRP CD2 CE3  sing Y N 352 
TRP NE1 CE2  sing Y N 353 
TRP NE1 HE1  sing N N 354 
TRP CE2 CZ2  sing Y N 355 
TRP CE3 CZ3  doub Y N 356 
TRP CE3 HE3  sing N N 357 
TRP CZ2 CH2  doub Y N 358 
TRP CZ2 HZ2  sing N N 359 
TRP CZ3 CH2  sing Y N 360 
TRP CZ3 HZ3  sing N N 361 
TRP CH2 HH2  sing N N 362 
TRP OXT HXT  sing N N 363 
TYR N   CA   sing N N 364 
TYR N   H    sing N N 365 
TYR N   H2   sing N N 366 
TYR CA  C    sing N N 367 
TYR CA  CB   sing N N 368 
TYR CA  HA   sing N N 369 
TYR C   O    doub N N 370 
TYR C   OXT  sing N N 371 
TYR CB  CG   sing N N 372 
TYR CB  HB2  sing N N 373 
TYR CB  HB3  sing N N 374 
TYR CG  CD1  doub Y N 375 
TYR CG  CD2  sing Y N 376 
TYR CD1 CE1  sing Y N 377 
TYR CD1 HD1  sing N N 378 
TYR CD2 CE2  doub Y N 379 
TYR CD2 HD2  sing N N 380 
TYR CE1 CZ   doub Y N 381 
TYR CE1 HE1  sing N N 382 
TYR CE2 CZ   sing Y N 383 
TYR CE2 HE2  sing N N 384 
TYR CZ  OH   sing N N 385 
TYR OH  HH   sing N N 386 
TYR OXT HXT  sing N N 387 
VAL N   CA   sing N N 388 
VAL N   H    sing N N 389 
VAL N   H2   sing N N 390 
VAL CA  C    sing N N 391 
VAL CA  CB   sing N N 392 
VAL CA  HA   sing N N 393 
VAL C   O    doub N N 394 
VAL C   OXT  sing N N 395 
VAL CB  CG1  sing N N 396 
VAL CB  CG2  sing N N 397 
VAL CB  HB   sing N N 398 
VAL CG1 HG11 sing N N 399 
VAL CG1 HG12 sing N N 400 
VAL CG1 HG13 sing N N 401 
VAL CG2 HG21 sing N N 402 
VAL CG2 HG22 sing N N 403 
VAL CG2 HG23 sing N N 404 
VAL OXT HXT  sing N N 405 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           22J12651 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5XCY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8X04 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018244 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014744 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011330 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 2.51340 1.74867 1.72398 ? 31.80534 0.44561  10.58317 ? 0.0 
;3-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 2.99955 2.25584 1.72788 ? 23.27268 7.45433  0.31622  ? 0.0 
;3-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ?       ? 15.80542 1.70748  ?        ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ?       ? 1.23737  29.19336 ?        ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? 27.29084  -25.77661 -23.69058 1.000 14.92190 ? 82   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? 27.99795  -26.64821 -22.75926 1.000 13.04666 ? 82   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? 27.24671  -27.96513 -22.64256 1.000 11.50809 ? 82   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? 26.16771  -28.12267 -23.21277 1.000 14.11354 ? 82   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? 28.10707  -25.98449 -21.39006 1.000 13.49716 ? 82   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? 26.81269  -25.69093 -20.90163 1.000 15.02835 ? 82   SER A OG  1 
ATOM   7    N N   . ALA A 1 2   ? 27.81347  -28.91939 -21.90045 1.000 10.50871 ? 83   ALA A N   1 
ATOM   8    C CA  . ALA A 1 2   ? 27.16177  -30.21733 -21.76108 1.000 9.61646  ? 83   ALA A CA  1 
ATOM   9    C C   . ALA A 1 2   ? 25.86360  -30.11893 -20.97541 1.000 8.59558  ? 83   ALA A C   1 
ATOM   10   O O   . ALA A 1 2   ? 24.89667  -30.83687 -21.26623 1.000 10.44087 ? 83   ALA A O   1 
ATOM   11   C CB  . ALA A 1 2   ? 28.09646  -31.20629 -21.06968 1.000 10.94285 ? 83   ALA A CB  1 
ATOM   12   N N   . ASN A 1 3   ? 25.83579  -29.26671 -19.96598 1.000 8.25695  ? 84   ASN A N   1 
ATOM   13   C CA  . ASN A 1 3   ? 24.74119  -29.21906 -19.00206 1.000 8.21175  ? 84   ASN A CA  1 
ATOM   14   C C   . ASN A 1 3   ? 23.96668  -27.92190 -19.18937 1.000 7.76523  ? 84   ASN A C   1 
ATOM   15   O O   . ASN A 1 3   ? 24.36234  -26.86826 -18.67581 1.000 9.44508  ? 84   ASN A O   1 
ATOM   16   C CB  . ASN A 1 3   ? 25.30332  -29.32508 -17.58945 1.000 9.30926  ? 84   ASN A CB  1 
ATOM   17   C CG  . ASN A 1 3   ? 24.23106  -29.21842 -16.54043 1.000 10.70770 ? 84   ASN A CG  1 
ATOM   18   O OD1 . ASN A 1 3   ? 23.08427  -29.59153 -16.78219 1.000 12.71789 ? 84   ASN A OD1 1 
ATOM   19   N ND2 . ASN A 1 3   ? 24.58148  -28.69154 -15.37607 1.000 10.83585 ? 84   ASN A ND2 1 
ATOM   20   N N   . ASN A 1 4   ? 22.86883  -27.99982 -19.93591 1.000 7.28946  ? 85   ASN A N   1 
ATOM   21   C CA  . ASN A 1 4   ? 21.97532  -26.86869 -20.10603 1.000 7.51323  ? 85   ASN A CA  1 
ATOM   22   C C   . ASN A 1 4   ? 20.96061  -26.93395 -18.98006 1.000 7.08626  ? 85   ASN A C   1 
ATOM   23   O O   . ASN A 1 4   ? 20.23045  -27.92365 -18.89585 1.000 7.80331  ? 85   ASN A O   1 
ATOM   24   C CB  . ASN A 1 4   ? 21.25599  -26.98141 -21.44075 1.000 7.94349  ? 85   ASN A CB  1 
ATOM   25   C CG  . ASN A 1 4   ? 20.38789  -25.77677 -21.73491 1.000 7.63127  ? 85   ASN A CG  1 
ATOM   26   O OD1 . ASN A 1 4   ? 19.68461  -25.27414 -20.85116 1.000 8.15898  ? 85   ASN A OD1 1 
ATOM   27   N ND2 . ASN A 1 4   ? 20.42084  -25.30649 -22.97378 1.000 7.88654  ? 85   ASN A ND2 1 
ATOM   28   N N   . PRO A 1 5   ? 20.87480  -25.93034 -18.09899 1.000 6.97643  ? 86   PRO A N   1 
ATOM   29   C CA  . PRO A 1 5   ? 19.97760  -26.06099 -16.93777 1.000 7.60669  ? 86   PRO A CA  1 
ATOM   30   C C   . PRO A 1 5   ? 18.53824  -26.41123 -17.27730 1.000 7.37650  ? 86   PRO A C   1 
ATOM   31   O O   . PRO A 1 5   ? 17.85202  -27.01510 -16.44521 1.000 8.05110  ? 86   PRO A O   1 
ATOM   32   C CB  . PRO A 1 5   ? 20.08419  -24.68796 -16.26606 1.000 8.03732  ? 86   PRO A CB  1 
ATOM   33   C CG  . PRO A 1 5   ? 21.46937  -24.22620 -16.62145 1.000 8.42814  ? 86   PRO A CG  1 
ATOM   34   C CD  . PRO A 1 5   ? 21.65615  -24.67617 -18.04757 1.000 7.73072  ? 86   PRO A CD  1 
ATOM   35   N N   . TRP A 1 6   ? 18.05421  -26.01788 -18.45294 1.000 7.25048  ? 87   TRP A N   1 
ATOM   36   C CA  . TRP A 1 6   ? 16.65665  -26.22743 -18.80620 1.000 8.15961  ? 87   TRP A CA  1 
ATOM   37   C C   . TRP A 1 6   ? 16.35206  -27.61455 -19.36767 1.000 7.97064  ? 87   TRP A C   1 
ATOM   38   O O   . TRP A 1 6   ? 15.19531  -28.03941 -19.30402 1.000 9.21123  ? 87   TRP A O   1 
ATOM   39   C CB  . TRP A 1 6   ? 16.20941  -25.16224 -19.81281 1.000 8.10626  ? 87   TRP A CB  1 
ATOM   40   C CG  . TRP A 1 6   ? 15.92067  -23.87988 -19.16030 1.000 7.58224  ? 87   TRP A CG  1 
ATOM   41   C CD1 . TRP A 1 6   ? 14.72613  -23.49322 -18.63175 1.000 8.41034  ? 87   TRP A CD1 1 
ATOM   42   C CD2 . TRP A 1 6   ? 16.84201  -22.80491 -18.91364 1.000 7.30345  ? 87   TRP A CD2 1 
ATOM   43   N NE1 . TRP A 1 6   ? 14.83601  -22.24817 -18.07044 1.000 8.81238  ? 87   TRP A NE1 1 
ATOM   44   C CE2 . TRP A 1 6   ? 16.12288  -21.80208 -18.23439 1.000 8.05927  ? 87   TRP A CE2 1 
ATOM   45   C CE3 . TRP A 1 6   ? 18.19950  -22.59459 -19.20459 1.000 7.89262  ? 87   TRP A CE3 1 
ATOM   46   C CZ2 . TRP A 1 6   ? 16.71164  -20.60647 -17.82992 1.000 8.98825  ? 87   TRP A CZ2 1 
ATOM   47   C CZ3 . TRP A 1 6   ? 18.78767  -21.40290 -18.80301 1.000 8.52874  ? 87   TRP A CZ3 1 
ATOM   48   C CH2 . TRP A 1 6   ? 18.04005  -20.42341 -18.12324 1.000 9.59359  ? 87   TRP A CH2 1 
ATOM   49   N N   A THR A 1 7   ? 17.32420  -28.32968 -19.92443 0.812 8.37931  ? 88   THR A N   1 
ATOM   50   N N   B THR A 1 7   ? 17.35554  -28.29157 -19.93557 0.188 8.46876  ? 88   THR A N   1 
ATOM   51   C CA  A THR A 1 7   ? 16.99011  -29.58182 -20.58722 0.812 9.27483  ? 88   THR A CA  1 
ATOM   52   C CA  B THR A 1 7   ? 17.16259  -29.54427 -20.66224 0.188 9.21621  ? 88   THR A CA  1 
ATOM   53   C C   A THR A 1 7   ? 16.50728  -30.60389 -19.55865 0.812 8.92455  ? 88   THR A C   1 
ATOM   54   C C   B THR A 1 7   ? 16.34377  -30.52155 -19.84022 0.188 8.40958  ? 88   THR A C   1 
ATOM   55   O O   A THR A 1 7   ? 17.13649  -30.81092 -18.51899 0.812 9.75153  ? 88   THR A O   1 
ATOM   56   O O   B THR A 1 7   ? 16.71515  -30.85035 -18.71388 0.188 8.36239  ? 88   THR A O   1 
ATOM   57   C CB  A THR A 1 7   ? 18.19415  -30.09680 -21.37315 0.812 9.45136  ? 88   THR A CB  1 
ATOM   58   C CB  B THR A 1 7   ? 18.52909  -30.17711 -20.93577 0.188 8.25354  ? 88   THR A CB  1 
ATOM   59   O OG1 A THR A 1 7   ? 18.59421  -29.10029 -22.32666 0.812 9.32423  ? 88   THR A OG1 1 
ATOM   60   O OG1 B THR A 1 7   ? 19.20549  -29.43665 -21.95405 0.188 10.53256 ? 88   THR A OG1 1 
ATOM   61   C CG2 A THR A 1 7   ? 17.85347  -31.39322 -22.10250 0.812 10.75802 ? 88   THR A CG2 1 
ATOM   62   C CG2 B THR A 1 7   ? 18.37354  -31.63397 -21.38903 0.188 9.14094  ? 88   THR A CG2 1 
ATOM   63   N N   A GLY A 1 8   ? 15.37565  -31.23413 -19.86111 0.812 9.04606  ? 89   GLY A N   1 
ATOM   64   N N   B GLY A 1 8   ? 15.24516  -31.00824 -20.41604 0.188 6.36935  ? 89   GLY A N   1 
ATOM   65   C CA  A GLY A 1 8   ? 14.80174  -32.25067 -19.01210 0.812 10.12748 ? 89   GLY A CA  1 
ATOM   66   C CA  B GLY A 1 8   ? 14.46446  -32.02972 -19.74777 0.188 8.73571  ? 89   GLY A CA  1 
ATOM   67   C C   A GLY A 1 8   ? 13.92838  -31.73117 -17.89979 0.812 8.75215  ? 89   GLY A C   1 
ATOM   68   C C   B GLY A 1 8   ? 13.96100  -31.52524 -18.41889 0.188 9.67594  ? 89   GLY A C   1 
ATOM   69   O O   A GLY A 1 8   ? 13.47002  -32.53567 -17.07617 0.812 10.00085 ? 89   GLY A O   1 
ATOM   70   O O   B GLY A 1 8   ? 14.16218  -32.15888 -17.37840 0.188 12.67134 ? 89   GLY A O   1 
ATOM   71   N N   A PHE A 1 9   ? 13.69286  -30.41763 -17.84237 0.812 8.65007  ? 90   PHE A N   1 
ATOM   72   N N   B PHE A 1 9   ? 13.33993  -30.35323 -18.44011 0.188 10.82185 ? 90   PHE A N   1 
ATOM   73   C CA  A PHE A 1 9   ? 12.90720  -29.78444 -16.79924 0.812 8.66920  ? 90   PHE A CA  1 
ATOM   74   C CA  B PHE A 1 9   ? 12.85097  -29.75170 -17.21658 0.188 10.40360 ? 90   PHE A CA  1 
ATOM   75   C C   A PHE A 1 9   ? 11.66804  -29.11147 -17.37198 0.812 9.03987  ? 90   PHE A C   1 
ATOM   76   C C   B PHE A 1 9   ? 11.61474  -28.95929 -17.59118 0.188 9.67397  ? 90   PHE A C   1 
ATOM   77   O O   A PHE A 1 9   ? 11.64159  -28.68603 -18.52901 0.812 10.19126 ? 90   PHE A O   1 
ATOM   78   O O   B PHE A 1 9   ? 11.59270  -28.29050 -18.62688 0.188 9.95361  ? 90   PHE A O   1 
ATOM   79   C CB  A PHE A 1 9   ? 13.75297  -28.75522 -16.03942 0.812 8.66124  ? 90   PHE A CB  1 
ATOM   80   C CB  B PHE A 1 9   ? 13.90733  -28.80840 -16.63026 0.188 12.89825 ? 90   PHE A CB  1 
ATOM   81   C CG  A PHE A 1 9   ? 14.72318  -29.39117 -15.09632 0.812 9.60671  ? 90   PHE A CG  1 
ATOM   82   C CG  B PHE A 1 9   ? 14.49299  -29.29258 -15.33940 0.188 9.86623  ? 90   PHE A CG  1 
ATOM   83   C CD1 A PHE A 1 9   ? 15.89536  -29.97056 -15.55673 0.812 12.23398 ? 90   PHE A CD1 1 
ATOM   84   C CD1 B PHE A 1 9   ? 13.86990  -29.04026 -14.13314 0.188 11.91127 ? 90   PHE A CD1 1 
ATOM   85   C CD2 A PHE A 1 9   ? 14.41217  -29.48860 -13.76135 0.812 9.97270  ? 90   PHE A CD2 1 
ATOM   86   C CD2 B PHE A 1 9   ? 15.68353  -30.00800 -15.33906 0.188 12.16620 ? 90   PHE A CD2 1 
ATOM   87   C CE1 A PHE A 1 9   ? 16.75097  -30.60236 -14.67194 0.812 13.12346 ? 90   PHE A CE1 1 
ATOM   88   C CE1 B PHE A 1 9   ? 14.41945  -29.49741 -12.95084 0.188 12.40153 ? 90   PHE A CE1 1 
ATOM   89   C CE2 A PHE A 1 9   ? 15.25144  -30.10740 -12.87916 0.812 11.96544 ? 90   PHE A CE2 1 
ATOM   90   C CE2 B PHE A 1 9   ? 16.23965  -30.46376 -14.15988 0.188 13.64341 ? 90   PHE A CE2 1 
ATOM   91   C CZ  A PHE A 1 9   ? 16.42759  -30.66349 -13.33178 0.812 13.78128 ? 90   PHE A CZ  1 
ATOM   92   C CZ  B PHE A 1 9   ? 15.60636  -30.21108 -12.96580 0.188 11.89793 ? 90   PHE A CZ  1 
ATOM   93   N N   A GLN A 1 10  ? 10.64922  -29.01069 -16.52868 0.812 9.51133  ? 91   GLN A N   1 
ATOM   94   N N   B GLN A 1 10  ? 10.58188  -29.06128 -16.76929 0.188 9.50873  ? 91   GLN A N   1 
ATOM   95   C CA  A GLN A 1 10  ? 9.41388   -28.29789 -16.81914 0.812 9.92547  ? 91   GLN A CA  1 
ATOM   96   C CA  B GLN A 1 10  ? 9.38886   -28.26023 -16.96039 0.188 10.14519 ? 91   GLN A CA  1 
ATOM   97   C C   A GLN A 1 10  ? 9.47272   -26.96416 -16.08622 0.812 8.94623  ? 91   GLN A C   1 
ATOM   98   C C   B GLN A 1 10  ? 9.55724   -26.98101 -16.15639 0.188 9.01767  ? 91   GLN A C   1 
ATOM   99   O O   A GLN A 1 10  ? 9.62882   -26.94981 -14.86345 0.812 9.80658  ? 91   GLN A O   1 
ATOM   100  O O   B GLN A 1 10  ? 9.92014   -27.02444 -14.97882 0.188 9.07238  ? 91   GLN A O   1 
ATOM   101  C CB  A GLN A 1 10  ? 8.24736   -29.11582 -16.26951 0.812 11.90036 ? 91   GLN A CB  1 
ATOM   102  C CB  B GLN A 1 10  ? 8.15219   -29.02751 -16.50106 0.188 11.65351 ? 91   GLN A CB  1 
ATOM   103  C CG  A GLN A 1 10  ? 6.90319   -28.54293 -16.59214 0.812 14.98136 ? 91   GLN A CG  1 
ATOM   104  C CG  B GLN A 1 10  ? 6.85191   -28.46028 -17.02528 0.188 15.75448 ? 91   GLN A CG  1 
ATOM   105  C CD  A GLN A 1 10  ? 6.56534   -28.72960 -18.04380 0.812 16.54605 ? 91   GLN A CD  1 
ATOM   106  C CD  B GLN A 1 10  ? 5.66460   -29.30561 -16.63032 0.188 13.46933 ? 91   GLN A CD  1 
ATOM   107  O OE1 A GLN A 1 10  ? 7.00470   -29.69363 -18.67012 0.812 17.17994 ? 91   GLN A OE1 1 
ATOM   108  O OE1 B GLN A 1 10  ? 5.66049   -30.52004 -16.83158 0.188 16.01060 ? 91   GLN A OE1 1 
ATOM   109  N NE2 A GLN A 1 10  ? 5.80695   -27.79506 -18.60202 0.812 20.53857 ? 91   GLN A NE2 1 
ATOM   110  N NE2 B GLN A 1 10  ? 4.64935   -28.67088 -16.06069 0.188 14.76491 ? 91   GLN A NE2 1 
ATOM   111  N N   . ILE A 1 11  ? 9.34020   -25.84783 -16.80673 1.000 9.25606  ? 92   ILE A N   1 
ATOM   112  C CA  . ILE A 1 11  ? 9.44526   -24.54948 -16.14143 1.000 8.24371  ? 92   ILE A CA  1 
ATOM   113  C C   . ILE A 1 11  ? 8.14753   -24.23804 -15.40696 1.000 8.88023  ? 92   ILE A C   1 
ATOM   114  O O   . ILE A 1 11  ? 7.05718   -24.26459 -15.99453 1.000 11.55076 ? 92   ILE A O   1 
ATOM   115  C CB  . ILE A 1 11  ? 9.78771   -23.42256 -17.12557 1.000 9.38169  ? 92   ILE A CB  1 
ATOM   116  C CG1 . ILE A 1 11  ? 11.05646  -23.72760 -17.91085 1.000 10.55070 ? 92   ILE A CG1 1 
ATOM   117  C CG2 . ILE A 1 11  ? 9.92346   -22.11265 -16.33998 1.000 10.47093 ? 92   ILE A CG2 1 
ATOM   118  C CD1 . ILE A 1 11  ? 11.23635  -22.82725 -19.12119 1.000 11.35890 ? 92   ILE A CD1 1 
ATOM   119  N N   . PHE A 1 12  ? 8.26793   -23.94041 -14.11704 1.000 8.25881  ? 93   PHE A N   1 
ATOM   120  C CA  . PHE A 1 12  ? 7.14003   -23.50261 -13.30768 1.000 8.85355  ? 93   PHE A CA  1 
ATOM   121  C C   . PHE A 1 12  ? 6.65305   -22.13896 -13.78831 1.000 7.92771  ? 93   PHE A C   1 
ATOM   122  O O   . PHE A 1 12  ? 7.44005   -21.19513 -13.89452 1.000 9.88833  ? 93   PHE A O   1 
ATOM   123  C CB  . PHE A 1 12  ? 7.59621   -23.41435 -11.85291 1.000 10.22779 ? 93   PHE A CB  1 
ATOM   124  C CG  . PHE A 1 12  ? 6.53440   -22.94886 -10.91336 1.000 10.29449 ? 93   PHE A CG  1 
ATOM   125  C CD1 . PHE A 1 12  ? 5.51627   -23.79273 -10.52223 1.000 12.13838 ? 93   PHE A CD1 1 
ATOM   126  C CD2 . PHE A 1 12  ? 6.56379   -21.66623 -10.39807 1.000 12.24024 ? 93   PHE A CD2 1 
ATOM   127  C CE1 . PHE A 1 12  ? 4.54017   -23.35328 -9.64343  1.000 12.55638 ? 93   PHE A CE1 1 
ATOM   128  C CE2 . PHE A 1 12  ? 5.59475   -21.22536 -9.52475  1.000 13.48036 ? 93   PHE A CE2 1 
ATOM   129  C CZ  . PHE A 1 12  ? 4.58391   -22.06483 -9.15033  1.000 13.47016 ? 93   PHE A CZ  1 
ATOM   130  N N   . LEU A 1 13  ? 5.35819   -22.03020 -14.06817 1.000 8.39544  ? 94   LEU A N   1 
ATOM   131  C CA  . LEU A 1 13  ? 4.78165   -20.77793 -14.55025 1.000 8.89255  ? 94   LEU A CA  1 
ATOM   132  C C   . LEU A 1 13  ? 4.41755   -19.86885 -13.37770 1.000 9.42693  ? 94   LEU A C   1 
ATOM   133  O O   . LEU A 1 13  ? 3.71964   -20.29550 -12.45426 1.000 12.29949 ? 94   LEU A O   1 
ATOM   134  C CB  . LEU A 1 13  ? 3.53327   -21.06885 -15.38379 1.000 9.36217  ? 94   LEU A CB  1 
ATOM   135  C CG  . LEU A 1 13  ? 3.79193   -21.77510 -16.71187 1.000 9.67935  ? 94   LEU A CG  1 
ATOM   136  C CD1 . LEU A 1 13  ? 2.48373   -22.22316 -17.31508 1.000 11.42032 ? 94   LEU A CD1 1 
ATOM   137  C CD2 . LEU A 1 13  ? 4.49307   -20.81723 -17.65122 1.000 13.02213 ? 94   LEU A CD2 1 
ATOM   138  N N   . SER A 1 14  ? 4.85111   -18.61259 -13.42212 1.000 9.85413  ? 95   SER A N   1 
ATOM   139  C CA  . SER A 1 14  ? 4.55677   -17.70992 -12.30356 1.000 10.54014 ? 95   SER A CA  1 
ATOM   140  C C   . SER A 1 14  ? 3.05401   -17.55725 -12.08946 1.000 10.06851 ? 95   SER A C   1 
ATOM   141  O O   . SER A 1 14  ? 2.36265   -17.09939 -13.00432 1.000 10.21657 ? 95   SER A O   1 
ATOM   142  C CB  . SER A 1 14  ? 5.11652   -16.32166 -12.57100 1.000 11.31385 ? 95   SER A CB  1 
ATOM   143  O OG  . SER A 1 14  ? 4.55267   -15.39084 -11.65699 1.000 11.86742 ? 95   SER A OG  1 
ATOM   144  N N   . PRO A 1 15  ? 2.51631   -17.85719 -10.90030 1.000 11.36728 ? 96   PRO A N   1 
ATOM   145  C CA  A PRO A 1 15  ? 1.08639   -17.60031 -10.66319 0.436 13.14196 ? 96   PRO A CA  1 
ATOM   146  C CA  B PRO A 1 15  ? 1.08385   -17.59627 -10.68343 0.564 13.14078 ? 96   PRO A CA  1 
ATOM   147  C C   . PRO A 1 15  ? 0.77823   -16.12482 -10.49443 1.000 12.27405 ? 96   PRO A C   1 
ATOM   148  O O   . PRO A 1 15  ? -0.35082  -15.69989 -10.76620 1.000 14.64272 ? 96   PRO A O   1 
ATOM   149  C CB  A PRO A 1 15  ? 0.78880   -18.39190 -9.37869  0.436 16.00511 ? 96   PRO A CB  1 
ATOM   150  C CB  B PRO A 1 15  ? 0.75088   -18.41904 -9.43182  0.564 15.99983 ? 96   PRO A CB  1 
ATOM   151  C CG  A PRO A 1 15  ? 1.99692   -19.28128 -9.16185  0.436 14.19149 ? 96   PRO A CG  1 
ATOM   152  C CG  B PRO A 1 15  ? 2.03175   -18.52626 -8.71658  0.564 13.02971 ? 96   PRO A CG  1 
ATOM   153  C CD  A PRO A 1 15  ? 3.14577   -18.53534 -9.75816  0.436 13.25709 ? 96   PRO A CD  1 
ATOM   154  C CD  B PRO A 1 15  ? 3.12329   -18.56157 -9.75985  0.564 13.25875 ? 96   PRO A CD  1 
ATOM   155  N N   . TYR A 1 16  ? 1.75526   -15.33916 -10.04398 1.000 12.41734 ? 97   TYR A N   1 
ATOM   156  C CA  . TYR A 1 16  ? 1.57624   -13.89746 -9.92227  1.000 11.89956 ? 97   TYR A CA  1 
ATOM   157  C C   . TYR A 1 16  ? 1.39063   -13.26470 -11.28941 1.000 12.61426 ? 97   TYR A C   1 
ATOM   158  O O   . TYR A 1 16  ? 0.45452   -12.48548 -11.49968 1.000 12.70578 ? 97   TYR A O   1 
ATOM   159  C CB  . TYR A 1 16  ? 2.78519   -13.28499 -9.21559  1.000 14.20698 ? 97   TYR A CB  1 
ATOM   160  C CG  . TYR A 1 16  ? 2.72000   -11.79088 -9.01699  1.000 14.44726 ? 97   TYR A CG  1 
ATOM   161  C CD1 . TYR A 1 16  ? 1.97129   -11.22968 -7.98887  1.000 16.39984 ? 97   TYR A CD1 1 
ATOM   162  C CD2 . TYR A 1 16  ? 3.41261   -10.93986 -9.86578  1.000 14.97606 ? 97   TYR A CD2 1 
ATOM   163  C CE1 . TYR A 1 16  ? 1.92176   -9.85747  -7.81327  1.000 23.28818 ? 97   TYR A CE1 1 
ATOM   164  C CE2 . TYR A 1 16  ? 3.37131   -9.57057  -9.70072  1.000 17.80582 ? 97   TYR A CE2 1 
ATOM   165  C CZ  . TYR A 1 16  ? 2.62337   -9.03325  -8.67446  1.000 22.06305 ? 97   TYR A CZ  1 
ATOM   166  O OH  . TYR A 1 16  ? 2.58412   -7.66555  -8.51175  1.000 26.37345 ? 97   TYR A OH  1 
ATOM   167  N N   . TYR A 1 17  ? 2.28437   -13.58074 -12.23353 1.000 11.12404 ? 98   TYR A N   1 
ATOM   168  C CA  . TYR A 1 17  ? 2.11126   -13.08755 -13.59298 1.000 10.56328 ? 98   TYR A CA  1 
ATOM   169  C C   . TYR A 1 17  ? 0.85224   -13.66294 -14.21457 1.000 11.19820 ? 98   TYR A C   1 
ATOM   170  O O   . TYR A 1 17  ? 0.13055   -12.95566 -14.91980 1.000 10.44678 ? 98   TYR A O   1 
ATOM   171  C CB  . TYR A 1 17  ? 3.33042   -13.40700 -14.45897 1.000 10.55740 ? 98   TYR A CB  1 
ATOM   172  C CG  . TYR A 1 17  ? 3.35882   -12.68461 -15.80070 1.000 9.62308  ? 98   TYR A CG  1 
ATOM   173  C CD1 . TYR A 1 17  ? 3.26836   -11.29339 -15.87713 1.000 10.29266 ? 98   TYR A CD1 1 
ATOM   174  C CD2 . TYR A 1 17  ? 3.50590   -13.39160 -16.98928 1.000 10.16343 ? 98   TYR A CD2 1 
ATOM   175  C CE1 . TYR A 1 17  ? 3.30894   -10.63127 -17.09862 1.000 10.53209 ? 98   TYR A CE1 1 
ATOM   176  C CE2 . TYR A 1 17  ? 3.55019   -12.73663 -18.21179 1.000 10.83406 ? 98   TYR A CE2 1 
ATOM   177  C CZ  . TYR A 1 17  ? 3.45151   -11.36149 -18.26126 1.000 10.43371 ? 98   TYR A CZ  1 
ATOM   178  O OH  . TYR A 1 17  ? 3.50386   -10.72676 -19.48429 1.000 11.10763 ? 98   TYR A OH  1 
ATOM   179  N N   . ALA A 1 18  ? 0.56046   -14.94006 -13.95360 1.000 10.64155 ? 99   ALA A N   1 
ATOM   180  C CA  . ALA A 1 18  ? -0.65819  -15.53331 -14.49738 1.000 11.17165 ? 99   ALA A CA  1 
ATOM   181  C C   . ALA A 1 18  ? -1.89323  -14.77589 -14.03003 1.000 12.51158 ? 99   ALA A C   1 
ATOM   182  O O   . ALA A 1 18  ? -2.81755  -14.54375 -14.81563 1.000 12.66653 ? 99   ALA A O   1 
ATOM   183  C CB  . ALA A 1 18  ? -0.76035  -17.01120 -14.12003 1.000 12.28230 ? 99   ALA A CB  1 
ATOM   184  N N   . ASN A 1 19  ? -1.92620  -14.38156 -12.75341 1.000 12.44640 ? 100  ASN A N   1 
ATOM   185  C CA  . ASN A 1 19  ? -3.05874  -13.60850 -12.24731 1.000 14.25439 ? 100  ASN A CA  1 
ATOM   186  C C   . ASN A 1 19  ? -3.11674  -12.22265 -12.87476 1.000 13.25237 ? 100  ASN A C   1 
ATOM   187  O O   . ASN A 1 19  ? -4.19990  -11.74141 -13.22543 1.000 13.83618 ? 100  ASN A O   1 
ATOM   188  C CB  . ASN A 1 19  ? -3.01619  -13.50550 -10.72208 1.000 15.15964 ? 100  ASN A CB  1 
ATOM   189  C CG  . ASN A 1 19  ? -3.29242  -14.82759 -10.03630 1.000 22.37701 ? 100  ASN A CG  1 
ATOM   190  O OD1 . ASN A 1 19  ? -2.97563  -15.00643 -8.86046  1.000 29.76430 ? 100  ASN A OD1 1 
ATOM   191  N ND2 . ASN A 1 19  ? -3.90155  -15.75897 -10.76502 1.000 25.92544 ? 100  ASN A ND2 1 
ATOM   192  N N   . GLU A 1 20  ? -1.96727  -11.55698 -13.01600 1.000 12.35328 ? 101  GLU A N   1 
ATOM   193  C CA  . GLU A 1 20  ? -1.96214  -10.26056 -13.68656 1.000 11.71695 ? 101  GLU A CA  1 
ATOM   194  C C   . GLU A 1 20  ? -2.47124  -10.39123 -15.11202 1.000 10.78476 ? 101  GLU A C   1 
ATOM   195  O O   . GLU A 1 20  ? -3.25725  -9.55849  -15.57839 1.000 11.86066 ? 101  GLU A O   1 
ATOM   196  C CB  . GLU A 1 20  ? -0.55250  -9.66994  -13.70207 1.000 13.47844 ? 101  GLU A CB  1 
ATOM   197  C CG  . GLU A 1 20  ? -0.01829  -9.21389  -12.35871 1.000 13.37773 ? 101  GLU A CG  1 
ATOM   198  C CD  . GLU A 1 20  ? 1.36772   -8.61743  -12.48657 1.000 13.80161 ? 101  GLU A CD  1 
ATOM   199  O OE1 . GLU A 1 20  ? 2.21788   -9.26242  -13.13098 1.000 14.06118 ? 101  GLU A OE1 1 
ATOM   200  O OE2 . GLU A 1 20  ? 1.61454   -7.52346  -11.94011 1.000 16.30539 ? 101  GLU A OE2 1 
ATOM   201  N N   A VAL A 1 21  ? -2.01004  -11.42309 -15.82143 0.741 10.81368 ? 102  VAL A N   1 
ATOM   202  N N   B VAL A 1 21  ? -2.06733  -11.45017 -15.81376 0.259 10.96481 ? 102  VAL A N   1 
ATOM   203  C CA  A VAL A 1 21  ? -2.42962  -11.64090 -17.20156 0.741 10.24401 ? 102  VAL A CA  1 
ATOM   204  C CA  B VAL A 1 21  ? -2.41807  -11.58190 -17.22566 0.259 10.38598 ? 102  VAL A CA  1 
ATOM   205  C C   A VAL A 1 21  ? -3.91748  -11.94921 -17.27550 0.741 10.87837 ? 102  VAL A C   1 
ATOM   206  C C   B VAL A 1 21  ? -3.90357  -11.88658 -17.40541 0.259 11.14201 ? 102  VAL A C   1 
ATOM   207  O O   A VAL A 1 21  ? -4.62202  -11.45403 -18.16209 0.741 11.41331 ? 102  VAL A O   1 
ATOM   208  O O   B VAL A 1 21  ? -4.57642  -11.27192 -18.24136 0.259 11.75288 ? 102  VAL A O   1 
ATOM   209  C CB  A VAL A 1 21  ? -1.56857  -12.73946 -17.85302 0.741 10.75885 ? 102  VAL A CB  1 
ATOM   210  C CB  B VAL A 1 21  ? -1.51249  -12.61422 -17.91819 0.259 10.86271 ? 102  VAL A CB  1 
ATOM   211  C CG1 A VAL A 1 21  ? -2.18388  -13.22068 -19.15680 0.741 9.76786  ? 102  VAL A CG1 1 
ATOM   212  C CG1 B VAL A 1 21  ? -1.97935  -12.85348 -19.33428 0.259 11.71314 ? 102  VAL A CG1 1 
ATOM   213  C CG2 A VAL A 1 21  ? -0.16449  -12.22109 -18.11173 0.741 10.89829 ? 102  VAL A CG2 1 
ATOM   214  C CG2 B VAL A 1 21  ? -0.07519  -12.11141 -17.93688 0.259 10.95511 ? 102  VAL A CG2 1 
ATOM   215  N N   A ALA A 1 22  ? -4.42091  -12.77784 -16.35975 0.741 11.58810 ? 103  ALA A N   1 
ATOM   216  N N   B ALA A 1 22  ? -4.43490  -12.84340 -16.63673 0.259 10.53763 ? 103  ALA A N   1 
ATOM   217  C CA  A ALA A 1 22  ? -5.84375  -13.09916 -16.37744 0.741 10.92104 ? 103  ALA A CA  1 
ATOM   218  C CA  B ALA A 1 22  ? -5.82914  -13.24697 -16.81012 0.259 11.37688 ? 103  ALA A CA  1 
ATOM   219  C C   A ALA A 1 22  ? -6.68623  -11.85088 -16.15051 0.741 10.88688 ? 103  ALA A C   1 
ATOM   220  C C   B ALA A 1 22  ? -6.77789  -12.06929 -16.63317 0.259 9.00096  ? 103  ALA A C   1 
ATOM   221  O O   A ALA A 1 22  ? -7.67574  -11.61575 -16.85605 0.741 12.35400 ? 103  ALA A O   1 
ATOM   222  O O   B ALA A 1 22  ? -7.78395  -11.95969 -17.34434 0.259 11.34602 ? 103  ALA A O   1 
ATOM   223  C CB  A ALA A 1 22  ? -6.15968  -14.17655 -15.33802 0.741 12.89261 ? 103  ALA A CB  1 
ATOM   224  C CB  B ALA A 1 22  ? -6.17879  -14.36953 -15.83401 0.259 11.90585 ? 103  ALA A CB  1 
ATOM   225  N N   A ALA A 1 23  ? -6.29938  -11.02791 -15.17409 0.741 11.76859 ? 104  ALA A N   1 
ATOM   226  N N   B ALA A 1 23  ? -6.47457  -11.17746 -15.68921 0.259 9.31040  ? 104  ALA A N   1 
ATOM   227  C CA  A ALA A 1 23  ? -7.05005  -9.80546  -14.91263 0.741 11.47955 ? 104  ALA A CA  1 
ATOM   228  C CA  B ALA A 1 23  ? -7.30328  -9.99248  -15.50360 0.259 11.75393 ? 104  ALA A CA  1 
ATOM   229  C C   A ALA A 1 23  ? -6.96546  -8.85316  -16.09556 0.741 10.01060 ? 104  ALA A C   1 
ATOM   230  C C   B ALA A 1 23  ? -7.18491  -9.03780  -16.68346 0.259 9.76754  ? 104  ALA A C   1 
ATOM   231  O O   A ALA A 1 23  ? -7.94991  -8.18827  -16.44351 0.741 11.99630 ? 104  ALA A O   1 
ATOM   232  O O   B ALA A 1 23  ? -8.15259  -8.34533  -17.02051 0.259 11.71209 ? 104  ALA A O   1 
ATOM   233  C CB  A ALA A 1 23  ? -6.53355  -9.13727  -13.64072 0.741 12.93101 ? 104  ALA A CB  1 
ATOM   234  C CB  B ALA A 1 23  ? -6.92138  -9.28794  -14.20234 0.259 13.64526 ? 104  ALA A CB  1 
ATOM   235  N N   A ALA A 1 24  ? -5.79524  -8.79121  -16.73388 0.741 9.83011  ? 105  ALA A N   1 
ATOM   236  N N   B ALA A 1 24  ? -6.01444  -8.99261  -17.32274 0.259 9.70263  ? 105  ALA A N   1 
ATOM   237  C CA  A ALA A 1 24  ? -5.60790  -7.92822  -17.89182 0.741 10.15462 ? 105  ALA A CA  1 
ATOM   238  C CA  B ALA A 1 24  ? -5.81840  -8.09421  -18.45398 0.259 8.82293  ? 105  ALA A CA  1 
ATOM   239  C C   A ALA A 1 24  ? -6.42669  -8.40686  -19.08099 0.741 9.90354  ? 105  ALA A C   1 
ATOM   240  C C   B ALA A 1 24  ? -6.58456  -8.56870  -19.68235 0.259 10.07659 ? 105  ALA A C   1 
ATOM   241  O O   A ALA A 1 24  ? -7.06518  -7.59927  -19.76880 0.741 10.45468 ? 105  ALA A O   1 
ATOM   242  O O   B ALA A 1 24  ? -7.17071  -7.75449  -20.40486 0.259 9.99087  ? 105  ALA A O   1 
ATOM   243  C CB  A ALA A 1 24  ? -4.12690  -7.88768  -18.25662 0.741 10.94451 ? 105  ALA A CB  1 
ATOM   244  C CB  B ALA A 1 24  ? -4.32857  -7.96531  -18.75828 0.259 9.97562  ? 105  ALA A CB  1 
ATOM   245  N N   A ALA A 1 25  ? -6.41785  -9.71485  -19.34141 0.741 10.83960 ? 106  ALA A N   1 
ATOM   246  N N   B ALA A 1 25  ? -6.59470  -9.88091  -19.93548 0.259 9.75211  ? 106  ALA A N   1 
ATOM   247  C CA  A ALA A 1 25  ? -7.06175  -10.22979 -20.54332 0.741 9.87269  ? 106  ALA A CA  1 
ATOM   248  C CA  B ALA A 1 25  ? -7.29191  -10.40707 -21.10419 0.259 11.00031 ? 106  ALA A CA  1 
ATOM   249  C C   A ALA A 1 25  ? -8.56501  -10.00938 -20.51029 0.741 10.49353 ? 106  ALA A C   1 
ATOM   250  C C   B ALA A 1 25  ? -8.78179  -10.08887 -21.08218 0.259 14.08108 ? 106  ALA A C   1 
ATOM   251  O O   A ALA A 1 25  ? -9.17119  -9.69846  -21.54112 0.741 12.51547 ? 106  ALA A O   1 
ATOM   252  O O   B ALA A 1 25  ? -9.41376  -10.06080 -22.14417 0.259 13.19432 ? 106  ALA A O   1 
ATOM   253  C CB  A ALA A 1 25  ? -6.74346  -11.71271 -20.71996 0.741 12.67370 ? 106  ALA A CB  1 
ATOM   254  C CB  B ALA A 1 25  ? -7.05891  -11.91463 -21.23194 0.259 9.58831  ? 106  ALA A CB  1 
ATOM   255  N N   A LYS A 1 26  ? -9.19086  -10.15511 -19.33936 0.741 11.43087 ? 107  LYS A N   1 
ATOM   256  N N   B LYS A 1 26  ? -9.35098  -9.83577  -19.90089 0.259 13.33280 ? 107  LYS A N   1 
ATOM   257  C CA  A LYS A 1 26  ? -10.63708 -9.97971  -19.27589 0.741 13.44954 ? 107  LYS A CA  1 
ATOM   258  C CA  B LYS A 1 26  ? -10.75136 -9.43370  -19.81920 0.259 13.65414 ? 107  LYS A CA  1 
ATOM   259  C C   A LYS A 1 26  ? -11.07282 -8.54048  -19.54190 0.741 11.58877 ? 107  LYS A C   1 
ATOM   260  C C   B LYS A 1 26  ? -10.95361 -8.03600  -20.39133 0.259 15.70005 ? 107  LYS A C   1 
ATOM   261  O O   A LYS A 1 26  ? -12.24846 -8.31309  -19.85573 0.741 14.14178 ? 107  LYS A O   1 
ATOM   262  O O   B LYS A 1 26  ? -11.88446 -7.80111  -21.17144 0.259 18.37232 ? 107  LYS A O   1 
ATOM   263  C CB  A LYS A 1 26  ? -11.19722 -10.50511 -17.95331 0.741 15.77721 ? 107  LYS A CB  1 
ATOM   264  C CB  B LYS A 1 26  ? -11.22483 -9.47486  -18.36619 0.259 16.30079 ? 107  LYS A CB  1 
ATOM   265  C CG  A LYS A 1 26  ? -11.01174 -9.57815  -16.78100 0.741 18.67422 ? 107  LYS A CG  1 
ATOM   266  C CG  B LYS A 1 26  ? -10.51698 -10.47701 -17.48635 0.259 17.34312 ? 107  LYS A CG  1 
ATOM   267  C CD  A LYS A 1 26  ? -10.83858 -10.36778 -15.49321 0.741 20.95116 ? 107  LYS A CD  1 
ATOM   268  C CD  B LYS A 1 26  ? -11.33166 -11.74126 -17.32263 0.259 16.27749 ? 107  LYS A CD  1 
ATOM   269  C CE  A LYS A 1 26  ? -10.71496 -9.44722  -14.28943 0.741 22.11250 ? 107  LYS A CE  1 
ATOM   270  C CE  B LYS A 1 26  ? -11.30841 -12.22131 -15.88064 0.259 18.38067 ? 107  LYS A CE  1 
ATOM   271  N NZ  A LYS A 1 26  ? -10.19195 -8.10343  -14.67353 0.741 18.82910 ? 107  LYS A NZ  1 
ATOM   272  N NZ  B LYS A 1 26  ? -11.32677 -11.08644 -14.91650 0.259 19.92913 ? 107  LYS A NZ  1 
ATOM   273  N N   A GLN A 1 27  ? -10.16332 -7.56939  -19.43109 0.741 12.19685 ? 108  GLN A N   1 
ATOM   274  N N   B GLN A 1 27  ? -10.09294 -7.08876  -20.00653 0.259 14.83731 ? 108  GLN A N   1 
ATOM   275  C CA  A GLN A 1 27  ? -10.46192 -6.18187  -19.76370 0.741 12.51947 ? 108  GLN A CA  1 
ATOM   276  C CA  B GLN A 1 27  ? -10.26133 -5.70491  -20.44130 0.259 13.98157 ? 108  GLN A CA  1 
ATOM   277  C C   A GLN A 1 27  ? -10.23737 -5.84985  -21.22996 0.741 12.41819 ? 108  GLN A C   1 
ATOM   278  C C   B GLN A 1 27  ? -10.00946 -5.51522  -21.93224 0.259 16.22395 ? 108  GLN A C   1 
ATOM   279  O O   A GLN A 1 27  ? -10.65959 -4.77585  -21.67433 0.741 14.68733 ? 108  GLN A O   1 
ATOM   280  O O   B GLN A 1 27  ? -10.50425 -4.54162  -22.50921 0.259 16.93384 ? 108  GLN A O   1 
ATOM   281  C CB  A GLN A 1 27  ? -9.62192  -5.21681  -18.92226 0.741 16.87379 ? 108  GLN A CB  1 
ATOM   282  C CB  B GLN A 1 27  ? -9.40203  -4.75525  -19.60298 0.259 15.40752 ? 108  GLN A CB  1 
ATOM   283  C CG  A GLN A 1 27  ? -9.72295  -5.41037  -17.42600 0.741 18.16203 ? 108  GLN A CG  1 
ATOM   284  C CG  B GLN A 1 27  ? -9.30824  -5.13366  -18.13283 0.259 16.57771 ? 108  GLN A CG  1 
ATOM   285  C CD  A GLN A 1 27  ? -8.59735  -4.71717  -16.68073 0.741 19.87145 ? 108  GLN A CD  1 
ATOM   286  C CD  B GLN A 1 27  ? -8.01112  -4.68371  -17.48953 0.259 19.01957 ? 108  GLN A CD  1 
ATOM   287  O OE1 A GLN A 1 27  ? -7.89781  -5.33353  -15.87786 0.741 22.53521 ? 108  GLN A OE1 1 
ATOM   288  O OE1 B GLN A 1 27  ? -7.19892  -5.50269  -17.06217 0.259 19.15083 ? 108  GLN A OE1 1 
ATOM   289  N NE2 A GLN A 1 27  ? -8.41466  -3.42816  -16.94773 0.741 23.04313 ? 108  GLN A NE2 1 
ATOM   290  N NE2 B GLN A 1 27  ? -7.81465  -3.37262  -17.41010 0.259 20.10678 ? 108  GLN A NE2 1 
ATOM   291  N N   A ILE A 1 28  ? -9.56357  -6.71502  -21.97746 0.741 11.60641 ? 109  ILE A N   1 
ATOM   292  N N   B ILE A 1 28  ? -9.25795  -6.41342  -22.56739 0.259 16.00107 ? 109  ILE A N   1 
ATOM   293  C CA  A ILE A 1 28  ? -9.34399  -6.46794  -23.39622 0.741 12.48892 ? 109  ILE A CA  1 
ATOM   294  C CA  B ILE A 1 28  ? -9.11289  -6.36792  -24.01655 0.259 15.07971 ? 109  ILE A CA  1 
ATOM   295  C C   A ILE A 1 28  ? -10.64340 -6.77085  -24.12558 0.741 14.09661 ? 109  ILE A C   1 
ATOM   296  C C   B ILE A 1 28  ? -10.44791 -6.72425  -24.65629 0.259 17.01998 ? 109  ILE A C   1 
ATOM   297  O O   A ILE A 1 28  ? -11.16156 -7.89027  -24.05377 0.741 16.42327 ? 109  ILE A O   1 
ATOM   298  O O   B ILE A 1 28  ? -11.05557 -7.75294  -24.33107 0.259 17.83627 ? 109  ILE A O   1 
ATOM   299  C CB  A ILE A 1 28  ? -8.17051  -7.29916  -23.92934 0.741 11.85259 ? 109  ILE A CB  1 
ATOM   300  C CB  B ILE A 1 28  ? -7.98876  -7.30737  -24.47828 0.259 15.61302 ? 109  ILE A CB  1 
ATOM   301  C CG1 A ILE A 1 28  ? -6.86221  -6.77707  -23.33208 0.741 10.22925 ? 109  ILE A CG1 1 
ATOM   302  C CG1 B ILE A 1 28  ? -6.62102  -6.64752  -24.27819 0.259 15.32394 ? 109  ILE A CG1 1 
ATOM   303  C CG2 A ILE A 1 28  ? -8.10420  -7.22949  -25.44792 0.741 13.58107 ? 109  ILE A CG2 1 
ATOM   304  C CG2 B ILE A 1 28  ? -8.17126  -7.67100  -25.93909 0.259 14.80248 ? 109  ILE A CG2 1 
ATOM   305  C CD1 A ILE A 1 28  ? -5.66139  -7.63229  -23.65843 0.741 12.15209 ? 109  ILE A CD1 1 
ATOM   306  C CD1 B ILE A 1 28  ? -5.72633  -7.33150  -23.25124 0.259 13.02509 ? 109  ILE A CD1 1 
ATOM   307  N N   A THR A 1 29  ? -11.18168 -5.75902  -24.80985 0.741 13.78777 ? 110  THR A N   1 
ATOM   308  N N   B THR A 1 29  ? -10.91470 -5.87023  -25.57045 0.259 17.55885 ? 110  THR A N   1 
ATOM   309  C CA  A THR A 1 29  ? -12.55815 -5.82852  -25.28829 0.741 15.71776 ? 110  THR A CA  1 
ATOM   310  C CA  B THR A 1 29  ? -12.27709 -5.99994  -26.07976 0.259 18.16521 ? 110  THR A CA  1 
ATOM   311  C C   A THR A 1 29  ? -12.68463 -6.64009  -26.57021 0.741 17.80439 ? 110  THR A C   1 
ATOM   312  C C   B THR A 1 29  ? -12.37542 -7.02328  -27.20645 0.259 19.78412 ? 110  THR A C   1 
ATOM   313  O O   A THR A 1 29  ? -13.65619 -7.38739  -26.73202 0.741 20.80529 ? 110  THR A O   1 
ATOM   314  O O   B THR A 1 29  ? -13.24013 -7.90548  -27.17207 0.259 22.45852 ? 110  THR A O   1 
ATOM   315  C CB  A THR A 1 29  ? -13.14877 -4.42274  -25.44229 0.741 16.19786 ? 110  THR A CB  1 
ATOM   316  C CB  B THR A 1 29  ? -12.80468 -4.63701  -26.52948 0.259 14.74797 ? 110  THR A CB  1 
ATOM   317  O OG1 A THR A 1 29  ? -12.42305 -3.68833  -26.43842 0.741 15.57307 ? 110  THR A OG1 1 
ATOM   318  O OG1 B THR A 1 29  ? -11.78071 -3.93909  -27.24824 0.259 21.38514 ? 110  THR A OG1 1 
ATOM   319  C CG2 A THR A 1 29  ? -13.07715 -3.68231  -24.12541 0.741 16.25373 ? 110  THR A CG2 1 
ATOM   320  C CG2 B THR A 1 29  ? -13.21163 -3.81193  -25.31871 0.259 16.95782 ? 110  THR A CG2 1 
ATOM   321  N N   A ASP A 1 30  ? -11.72778 -6.51510  -27.48457 0.741 19.66512 ? 111  ASP A N   1 
ATOM   322  N N   B ASP A 1 30  ? -11.51299 -6.91690  -28.21614 0.259 19.05023 ? 111  ASP A N   1 
ATOM   323  C CA  A ASP A 1 30  ? -11.74596 -7.34516  -28.68041 0.741 19.08961 ? 111  ASP A CA  1 
ATOM   324  C CA  B ASP A 1 30  ? -11.59060 -7.80891  -29.36763 0.259 20.42801 ? 111  ASP A CA  1 
ATOM   325  C C   A ASP A 1 30  ? -11.56893 -8.80352  -28.27831 0.741 17.59028 ? 111  ASP A C   1 
ATOM   326  C C   B ASP A 1 30  ? -11.43496 -9.25532  -28.90954 0.259 20.84147 ? 111  ASP A C   1 
ATOM   327  O O   A ASP A 1 30  ? -10.54857 -9.14858  -27.65875 0.741 16.37952 ? 111  ASP A O   1 
ATOM   328  O O   B ASP A 1 30  ? -10.37547 -9.61762  -28.37512 0.259 18.81985 ? 111  ASP A O   1 
ATOM   329  C CB  A ASP A 1 30  ? -10.64414 -6.94076  -29.65246 0.741 22.11185 ? 111  ASP A CB  1 
ATOM   330  C CB  B ASP A 1 30  ? -10.51856 -7.46084  -30.39668 0.259 21.43021 ? 111  ASP A CB  1 
ATOM   331  C CG  A ASP A 1 30  ? -10.65354 -7.77800  -30.91706 0.741 23.22618 ? 111  ASP A CG  1 
ATOM   332  C CG  B ASP A 1 30  ? -10.56682 -8.36920  -31.61222 0.259 22.69268 ? 111  ASP A CG  1 
ATOM   333  O OD1 A ASP A 1 30  ? -11.49986 -7.52314  -31.80116 0.741 26.69273 ? 111  ASP A OD1 1 
ATOM   334  O OD1 B ASP A 1 30  ? -11.67885 -8.61456  -32.12395 0.259 21.97812 ? 111  ASP A OD1 1 
ATOM   335  O OD2 A ASP A 1 30  ? -9.82150  -8.70257  -31.02275 0.741 22.25604 ? 111  ASP A OD2 1 
ATOM   336  O OD2 B ASP A 1 30  ? -9.49362  -8.83056  -32.06011 0.259 21.84889 ? 111  ASP A OD2 1 
ATOM   337  N N   A PRO A 1 31  ? -12.52142 -9.68381  -28.59890 0.741 20.63699 ? 112  PRO A N   1 
ATOM   338  N N   B PRO A 1 31  ? -12.45544 -10.10124 -29.08475 0.259 20.97236 ? 112  PRO A N   1 
ATOM   339  C CA  A PRO A 1 31  ? -12.42739 -11.06426 -28.09853 0.741 18.96730 ? 112  PRO A CA  1 
ATOM   340  C CA  B PRO A 1 31  ? -12.40300 -11.45598 -28.50620 0.259 21.58565 ? 112  PRO A CA  1 
ATOM   341  C C   A PRO A 1 31  ? -11.22499 -11.82452 -28.62846 0.741 19.82958 ? 112  PRO A C   1 
ATOM   342  C C   B PRO A 1 31  ? -11.20332 -12.27225 -28.94576 0.259 21.13932 ? 112  PRO A C   1 
ATOM   343  O O   A PRO A 1 31  ? -10.62618 -12.61418 -27.88681 0.741 18.92891 ? 112  PRO A O   1 
ATOM   344  O O   B PRO A 1 31  ? -10.72590 -13.11405 -28.17405 0.259 21.23145 ? 112  PRO A O   1 
ATOM   345  C CB  A PRO A 1 31  ? -13.75540 -11.69553 -28.54464 0.741 23.71304 ? 112  PRO A CB  1 
ATOM   346  C CB  B PRO A 1 31  ? -13.72635 -12.09164 -28.96220 0.259 23.29138 ? 112  PRO A CB  1 
ATOM   347  C CG  A PRO A 1 31  ? -14.66344 -10.53745 -28.82190 0.741 24.20453 ? 112  PRO A CG  1 
ATOM   348  C CG  B PRO A 1 31  ? -14.25339 -11.19305 -30.04258 0.259 22.08711 ? 112  PRO A CG  1 
ATOM   349  C CD  A PRO A 1 31  ? -13.77573 -9.44317  -29.32834 0.741 20.70891 ? 112  PRO A CD  1 
ATOM   350  C CD  B PRO A 1 31  ? -13.75146 -9.82599  -29.72627 0.259 21.92323 ? 112  PRO A CD  1 
ATOM   351  N N   A THR A 1 32  ? -10.85662 -11.61245 -29.89443 0.741 19.71025 ? 113  THR A N   1 
ATOM   352  N N   B THR A 1 32  ? -10.70298 -12.05946 -30.16401 0.259 21.39349 ? 113  THR A N   1 
ATOM   353  C CA  A THR A 1 32  ? -9.72127  -12.32714 -30.47094 0.741 22.00257 ? 113  THR A CA  1 
ATOM   354  C CA  B THR A 1 32  ? -9.45414  -12.69557 -30.56619 0.259 21.87583 ? 113  THR A CA  1 
ATOM   355  C C   A THR A 1 32  ? -8.41806  -11.92870 -29.79128 0.741 17.80158 ? 113  THR A C   1 
ATOM   356  C C   B THR A 1 32  ? -8.30834  -12.22492 -29.68094 0.259 18.81239 ? 113  THR A C   1 
ATOM   357  O O   A THR A 1 32  ? -7.55632  -12.77797 -29.52864 0.741 16.65077 ? 113  THR A O   1 
ATOM   358  O O   B THR A 1 32  ? -7.68540  -13.02181 -28.97021 0.259 17.97145 ? 113  THR A O   1 
ATOM   359  C CB  A THR A 1 32  ? -9.64904  -12.04708 -31.97251 0.741 23.23635 ? 113  THR A CB  1 
ATOM   360  C CB  B THR A 1 32  ? -9.16292  -12.39088 -32.03615 0.259 22.80917 ? 113  THR A CB  1 
ATOM   361  O OG1 A THR A 1 32  ? -10.84878 -12.51373 -32.60263 0.741 27.09017 ? 113  THR A OG1 1 
ATOM   362  O OG1 B THR A 1 32  ? -10.33151 -12.65092 -32.82322 0.259 24.63690 ? 113  THR A OG1 1 
ATOM   363  C CG2 A THR A 1 32  ? -8.45185  -12.74792 -32.59515 0.741 24.38607 ? 113  THR A CG2 1 
ATOM   364  C CG2 B THR A 1 32  ? -8.01165  -13.25032 -32.53967 0.259 23.02341 ? 113  THR A CG2 1 
ATOM   365  N N   A LEU A 1 33  ? -8.25963  -10.63992 -29.49893 0.741 15.70664 ? 114  LEU A N   1 
ATOM   366  N N   B LEU A 1 33  ? -8.04469  -10.91405 -29.68983 0.259 17.15931 ? 114  LEU A N   1 
ATOM   367  C CA  A LEU A 1 33  ? -7.06878  -10.17792 -28.80121 0.741 14.93252 ? 114  LEU A CA  1 
ATOM   368  C CA  B LEU A 1 33  ? -6.93689  -10.35045 -28.92396 0.259 15.25248 ? 114  LEU A CA  1 
ATOM   369  C C   A LEU A 1 33  ? -7.06270  -10.65357 -27.35326 0.741 12.86450 ? 114  LEU A C   1 
ATOM   370  C C   B LEU A 1 33  ? -7.02161  -10.70685 -27.44431 0.259 12.88121 ? 114  LEU A C   1 
ATOM   371  O O   A LEU A 1 33  ? -6.00617  -11.01374 -26.81594 0.741 12.39043 ? 114  LEU A O   1 
ATOM   372  O O   B LEU A 1 33  ? -5.98776  -10.81899 -26.77277 0.259 12.61497 ? 114  LEU A O   1 
ATOM   373  C CB  A LEU A 1 33  ? -7.01420  -8.65601  -28.87621 0.741 15.36333 ? 114  LEU A CB  1 
ATOM   374  C CB  B LEU A 1 33  ? -6.90891  -8.83351  -29.10704 0.259 15.93104 ? 114  LEU A CB  1 
ATOM   375  C CG  A LEU A 1 33  ? -5.71230  -7.98947  -28.46028 0.741 13.25747 ? 114  LEU A CG  1 
ATOM   376  C CG  B LEU A 1 33  ? -5.62387  -8.11731  -28.69716 0.259 14.06350 ? 114  LEU A CG  1 
ATOM   377  C CD1 A LEU A 1 33  ? -4.56804  -8.45130  -29.34531 0.741 14.49284 ? 114  LEU A CD1 1 
ATOM   378  C CD1 B LEU A 1 33  ? -4.45741  -8.58630  -29.55053 0.259 15.06449 ? 114  LEU A CD1 1 
ATOM   379  C CD2 A LEU A 1 33  ? -5.88003  -6.48326  -28.54003 0.741 15.64248 ? 114  LEU A CD2 1 
ATOM   380  C CD2 B LEU A 1 33  ? -5.80188  -6.61155  -28.80151 0.259 15.53038 ? 114  LEU A CD2 1 
ATOM   381  N N   A SER A 1 34  ? -8.23772  -10.67333 -26.71387 0.741 14.67508 ? 115  SER A N   1 
ATOM   382  N N   B SER A 1 34  ? -8.23545  -10.88734 -26.91816 0.259 14.85288 ? 115  SER A N   1 
ATOM   383  C CA  A SER A 1 34  ? -8.34281  -11.14207 -25.33401 0.741 13.66474 ? 115  SER A CA  1 
ATOM   384  C CA  B SER A 1 34  ? -8.37830  -11.32609 -25.53378 0.259 14.59322 ? 115  SER A CA  1 
ATOM   385  C C   A SER A 1 34  ? -7.85454  -12.58049 -25.19261 0.741 14.24790 ? 115  SER A C   1 
ATOM   386  C C   B SER A 1 34  ? -7.81074  -12.72665 -25.34276 0.259 14.28602 ? 115  SER A C   1 
ATOM   387  O O   A SER A 1 34  ? -7.15205  -12.91458 -24.22839 0.741 13.45222 ? 115  SER A O   1 
ATOM   388  O O   B SER A 1 34  ? -7.10633  -12.99285 -24.36118 0.259 13.55606 ? 115  SER A O   1 
ATOM   389  C CB  A SER A 1 34  ? -9.79273  -11.01823 -24.85893 0.741 14.41644 ? 115  SER A CB  1 
ATOM   390  C CB  B SER A 1 34  ? -9.84845  -11.27848 -25.11693 0.259 15.94614 ? 115  SER A CB  1 
ATOM   391  O OG  A SER A 1 34  ? -9.93122  -11.41173 -23.50498 0.741 15.01188 ? 115  SER A OG  1 
ATOM   392  O OG  B SER A 1 34  ? -10.43313 -10.02983 -25.44337 0.259 19.87647 ? 115  SER A OG  1 
ATOM   393  N N   A SER A 1 35  ? -8.22051  -13.44794 -26.14269 0.741 15.46711 ? 116  SER A N   1 
ATOM   394  N N   B SER A 1 35  ? -8.10451  -13.63545 -26.27565 0.259 15.54115 ? 116  SER A N   1 
ATOM   395  C CA  A SER A 1 35  ? -7.78862  -14.84221 -26.08689 0.741 16.20967 ? 116  SER A CA  1 
ATOM   396  C CA  B SER A 1 35  ? -7.56362  -14.98803 -26.19022 0.259 15.98212 ? 116  SER A CA  1 
ATOM   397  C C   A SER A 1 35  ? -6.27746  -14.96536 -26.24287 0.741 14.14179 ? 116  SER A C   1 
ATOM   398  C C   B SER A 1 35  ? -6.04973  -14.99353 -26.36721 0.259 14.55903 ? 116  SER A C   1 
ATOM   399  O O   A SER A 1 35  ? -5.63562  -15.75521 -25.53867 0.741 15.14172 ? 116  SER A O   1 
ATOM   400  O O   B SER A 1 35  ? -5.34238  -15.73681 -25.67667 0.259 14.80005 ? 116  SER A O   1 
ATOM   401  C CB  A SER A 1 35  ? -8.50455  -15.65075 -27.16725 0.741 18.59283 ? 116  SER A CB  1 
ATOM   402  C CB  B SER A 1 35  ? -8.23582  -15.88422 -27.22773 0.259 18.47146 ? 116  SER A CB  1 
ATOM   403  O OG  A SER A 1 35  ? -9.90718  -15.47176 -27.09207 0.741 23.55108 ? 116  SER A OG  1 
ATOM   404  O OG  B SER A 1 35  ? -7.82084  -15.53551 -28.53569 0.259 18.82969 ? 116  SER A OG  1 
ATOM   405  N N   A LYS A 1 36  ? -5.69731  -14.20852 -27.17482 0.741 13.79878 ? 117  LYS A N   1 
ATOM   406  N N   B LYS A 1 36  ? -5.53418  -14.17580 -27.29104 0.259 14.40752 ? 117  LYS A N   1 
ATOM   407  C CA  A LYS A 1 36  ? -4.24599  -14.18384 -27.32511 0.741 13.71375 ? 117  LYS A CA  1 
ATOM   408  C CA  B LYS A 1 36  ? -4.08686  -14.06026 -27.45295 0.259 14.23521 ? 117  LYS A CA  1 
ATOM   409  C C   A LYS A 1 36  ? -3.58532  -13.71212 -26.04008 0.741 10.22089 ? 117  LYS A C   1 
ATOM   410  C C   B LYS A 1 36  ? -3.42931  -13.52621 -26.18668 0.259 11.69014 ? 117  LYS A C   1 
ATOM   411  O O   A LYS A 1 36  ? -2.59884  -14.29837 -25.57407 0.741 10.11566 ? 117  LYS A O   1 
ATOM   412  O O   B LYS A 1 36  ? -2.30214  -13.91739 -25.86020 0.259 13.95380 ? 117  LYS A O   1 
ATOM   413  C CB  A LYS A 1 36  ? -3.87982  -13.22223 -28.45182 0.741 14.29523 ? 117  LYS A CB  1 
ATOM   414  C CB  B LYS A 1 36  ? -3.75461  -13.14484 -28.63181 0.259 15.33373 ? 117  LYS A CB  1 
ATOM   415  C CG  A LYS A 1 36  ? -4.20213  -13.70106 -29.84436 0.741 16.59825 ? 117  LYS A CG  1 
ATOM   416  C CG  B LYS A 1 36  ? -4.80062  -13.13764 -29.73328 0.259 18.81809 ? 117  LYS A CG  1 
ATOM   417  C CD  A LYS A 1 36  ? -3.78662  -15.12637 -30.04655 0.741 23.97692 ? 117  LYS A CD  1 
ATOM   418  C CD  B LYS A 1 36  ? -4.26299  -12.62952 -31.06014 0.259 18.12428 ? 117  LYS A CD  1 
ATOM   419  C CE  A LYS A 1 36  ? -4.20530  -15.61377 -31.41389 0.741 24.34040 ? 117  LYS A CE  1 
ATOM   420  C CE  B LYS A 1 36  ? -4.22000  -13.72461 -32.11119 0.259 19.68070 ? 117  LYS A CE  1 
ATOM   421  N NZ  A LYS A 1 36  ? -4.10988  -17.09406 -31.50861 0.741 26.99257 ? 117  LYS A NZ  1 
ATOM   422  N NZ  B LYS A 1 36  ? -4.38827  -13.16618 -33.48452 0.259 20.16883 ? 117  LYS A NZ  1 
ATOM   423  N N   . ALA A 1 37  ? -4.11461  -12.63338 -25.46353 1.000 11.47555 ? 118  ALA A N   1 
ATOM   424  C CA  . ALA A 1 37  ? -3.56804  -12.10514 -24.22035 1.000 10.58272 ? 118  ALA A CA  1 
ATOM   425  C C   . ALA A 1 37  ? -3.60587  -13.14844 -23.11614 1.000 10.42829 ? 118  ALA A C   1 
ATOM   426  O O   . ALA A 1 37  ? -2.62217  -13.31690 -22.38833 1.000 10.37046 ? 118  ALA A O   1 
ATOM   427  C CB  . ALA A 1 37  ? -4.35120  -10.86810 -23.80119 1.000 10.51744 ? 118  ALA A CB  1 
ATOM   428  N N   . ALA A 1 38  ? -4.71773  -13.87584 -22.99111 1.000 10.83278 ? 119  ALA A N   1 
ATOM   429  C CA  . ALA A 1 38  ? -4.82286  -14.87638 -21.93840 1.000 11.44431 ? 119  ALA A CA  1 
ATOM   430  C C   . ALA A 1 38  ? -3.74353  -15.93838 -22.07004 1.000 11.13766 ? 119  ALA A C   1 
ATOM   431  O O   . ALA A 1 38  ? -3.24011  -16.44617 -21.05796 1.000 11.69962 ? 119  ALA A O   1 
ATOM   432  C CB  . ALA A 1 38  ? -6.20490  -15.52466 -21.98225 1.000 12.60534 ? 119  ALA A CB  1 
ATOM   433  N N   . SER A 1 39  ? -3.36576  -16.26968 -23.30511 1.000 10.96237 ? 120  SER A N   1 
ATOM   434  C CA  . SER A 1 39  ? -2.37949  -17.31286 -23.54762 1.000 11.34346 ? 120  SER A CA  1 
ATOM   435  C C   . SER A 1 39  ? -0.99612  -16.93777 -23.03867 1.000 10.04388 ? 120  SER A C   1 
ATOM   436  O O   . SER A 1 39  ? -0.15143  -17.82308 -22.87456 1.000 10.00083 ? 120  SER A O   1 
ATOM   437  C CB  . SER A 1 39  ? -2.33142  -17.65529 -25.04150 1.000 12.54418 ? 120  SER A CB  1 
ATOM   438  O OG  . SER A 1 39  ? -1.56868  -16.71556 -25.78211 1.000 13.13395 ? 120  SER A OG  1 
ATOM   439  N N   . VAL A 1 40  ? -0.74965  -15.65346 -22.78279 1.000 9.63903  ? 121  VAL A N   1 
ATOM   440  C CA  . VAL A 1 40  ? 0.55061   -15.22005 -22.27892 1.000 9.36411  ? 121  VAL A CA  1 
ATOM   441  C C   . VAL A 1 40  ? 0.84905   -15.84017 -20.91807 1.000 8.87942  ? 121  VAL A C   1 
ATOM   442  O O   . VAL A 1 40  ? 2.01506   -16.04971 -20.56685 1.000 9.49386  ? 121  VAL A O   1 
ATOM   443  C CB  . VAL A 1 40  ? 0.61758   -13.67997 -22.26164 1.000 9.54038  ? 121  VAL A CB  1 
ATOM   444  C CG1 . VAL A 1 40  ? 1.87704   -13.17840 -21.58569 1.000 10.12970 ? 121  VAL A CG1 1 
ATOM   445  C CG2 . VAL A 1 40  ? 0.52580   -13.14434 -23.67610 1.000 11.75987 ? 121  VAL A CG2 1 
ATOM   446  N N   . ALA A 1 41  ? -0.18965  -16.17948 -20.14870 1.000 9.40235  ? 122  ALA A N   1 
ATOM   447  C CA  . ALA A 1 41  ? 0.01188   -16.80018 -18.84302 1.000 10.27025 ? 122  ALA A CA  1 
ATOM   448  C C   . ALA A 1 41  ? 0.67863   -18.16701 -18.93987 1.000 9.89190  ? 122  ALA A C   1 
ATOM   449  O O   . ALA A 1 41  ? 1.17612   -18.67384 -17.92521 1.000 9.93861  ? 122  ALA A O   1 
ATOM   450  C CB  . ALA A 1 41  ? -1.32489  -16.93682 -18.11255 1.000 11.06964 ? 122  ALA A CB  1 
ATOM   451  N N   . ASN A 1 42  ? 0.68659   -18.77303 -20.12840 1.000 8.98669  ? 123  ASN A N   1 
ATOM   452  C CA  . ASN A 1 42  ? 1.32421   -20.06306 -20.36063 1.000 9.23804  ? 123  ASN A CA  1 
ATOM   453  C C   . ASN A 1 42  ? 2.77486   -19.94353 -20.79880 1.000 8.46385  ? 123  ASN A C   1 
ATOM   454  O O   . ASN A 1 42  ? 3.40976   -20.96601 -21.07920 1.000 9.74986  ? 123  ASN A O   1 
ATOM   455  C CB  . ASN A 1 42  ? 0.55483   -20.85023 -21.42729 1.000 10.38506 ? 123  ASN A CB  1 
ATOM   456  C CG  . ASN A 1 42  ? -0.88863  -21.08043 -21.05339 1.000 11.45493 ? 123  ASN A CG  1 
ATOM   457  O OD1 . ASN A 1 42  ? -1.19782  -21.35067 -19.90094 1.000 15.45303 ? 123  ASN A OD1 1 
ATOM   458  N ND2 . ASN A 1 42  ? -1.78018  -20.99625 -22.03466 1.000 15.35406 ? 123  ASN A ND2 1 
ATOM   459  N N   . ILE A 1 43  ? 3.30728   -18.73190 -20.87278 1.000 8.26576  ? 124  ILE A N   1 
ATOM   460  C CA  . ILE A 1 43  ? 4.67280   -18.48943 -21.33635 1.000 8.36603  ? 124  ILE A CA  1 
ATOM   461  C C   . ILE A 1 43  ? 5.54604   -18.24823 -20.11054 1.000 8.39338  ? 124  ILE A C   1 
ATOM   462  O O   . ILE A 1 43  ? 5.22778   -17.35585 -19.31050 1.000 9.46355  ? 124  ILE A O   1 
ATOM   463  C CB  . ILE A 1 43  ? 4.74273   -17.29558 -22.29983 1.000 9.13870  ? 124  ILE A CB  1 
ATOM   464  C CG1 . ILE A 1 43  ? 3.78383   -17.50416 -23.47597 1.000 9.36681  ? 124  ILE A CG1 1 
ATOM   465  C CG2 . ILE A 1 43  ? 6.15748   -17.11420 -22.79081 1.000 9.50189  ? 124  ILE A CG2 1 
ATOM   466  C CD1 . ILE A 1 43  ? 3.66320   -16.31234 -24.40949 1.000 10.73948 ? 124  ILE A CD1 1 
ATOM   467  N N   . PRO A 1 44  ? 6.62657   -18.99573 -19.92333 1.000 7.97558  ? 125  PRO A N   1 
ATOM   468  C CA  . PRO A 1 44  ? 7.40295   -18.85739 -18.68667 1.000 8.71536  ? 125  PRO A CA  1 
ATOM   469  C C   . PRO A 1 44  ? 8.16296   -17.53881 -18.61817 1.000 7.51724  ? 125  PRO A C   1 
ATOM   470  O O   . PRO A 1 44  ? 8.77015   -17.08893 -19.59704 1.000 7.95982  ? 125  PRO A O   1 
ATOM   471  C CB  . PRO A 1 44  ? 8.36778   -20.04585 -18.73974 1.000 10.12926 ? 125  PRO A CB  1 
ATOM   472  C CG  . PRO A 1 44  ? 8.46936   -20.38027 -20.17549 1.000 10.39630 ? 125  PRO A CG  1 
ATOM   473  C CD  . PRO A 1 44  ? 7.13486   -20.07794 -20.78208 1.000 8.81821  ? 125  PRO A CD  1 
ATOM   474  N N   . THR A 1 45  ? 8.13254   -16.94321 -17.42413 1.000 8.46810  ? 126  THR A N   1 
ATOM   475  C CA  . THR A 1 45  ? 8.81518   -15.69818 -17.11034 1.000 8.03967  ? 126  THR A CA  1 
ATOM   476  C C   . THR A 1 45  ? 9.62544   -15.87122 -15.82698 1.000 7.29566  ? 126  THR A C   1 
ATOM   477  O O   . THR A 1 45  ? 9.47839   -16.84636 -15.08413 1.000 8.23241  ? 126  THR A O   1 
ATOM   478  C CB  . THR A 1 45  ? 7.81704   -14.53773 -16.93111 1.000 8.22998  ? 126  THR A CB  1 
ATOM   479  O OG1 . THR A 1 45  ? 6.90360   -14.83552 -15.87220 1.000 8.84701  ? 126  THR A OG1 1 
ATOM   480  C CG2 . THR A 1 45  ? 7.05251   -14.24676 -18.21579 1.000 9.68800  ? 126  THR A CG2 1 
ATOM   481  N N   . PHE A 1 46  ? 10.49901  -14.89967 -15.56399 1.000 7.30040  ? 127  PHE A N   1 
ATOM   482  C CA  . PHE A 1 46  ? 11.24155  -14.86057 -14.31044 1.000 7.12249  ? 127  PHE A CA  1 
ATOM   483  C C   . PHE A 1 46  ? 10.47907  -14.07031 -13.24787 1.000 7.22920  ? 127  PHE A C   1 
ATOM   484  O O   . PHE A 1 46  ? 9.85065   -13.04769 -13.53817 1.000 8.12584  ? 127  PHE A O   1 
ATOM   485  C CB  . PHE A 1 46  ? 12.61968  -14.22620 -14.53140 1.000 7.61472  ? 127  PHE A CB  1 
ATOM   486  C CG  . PHE A 1 46  ? 13.65410  -15.18490 -15.09265 1.000 6.62358  ? 127  PHE A CG  1 
ATOM   487  C CD1 . PHE A 1 46  ? 13.51550  -15.74847 -16.35378 1.000 7.57522  ? 127  PHE A CD1 1 
ATOM   488  C CD2 . PHE A 1 46  ? 14.76110  -15.53136 -14.33980 1.000 7.40466  ? 127  PHE A CD2 1 
ATOM   489  C CE1 . PHE A 1 46  ? 14.44944  -16.66025 -16.83554 1.000 7.69291  ? 127  PHE A CE1 1 
ATOM   490  C CE2 . PHE A 1 46  ? 15.70223  -16.43421 -14.83263 1.000 8.24835  ? 127  PHE A CE2 1 
ATOM   491  C CZ  . PHE A 1 46  ? 15.54240  -16.98930 -16.07868 1.000 8.21978  ? 127  PHE A CZ  1 
ATOM   492  N N   . THR A 1 47  ? 10.56437  -14.54614 -12.00374 1.000 7.16961  ? 128  THR A N   1 
ATOM   493  C CA  . THR A 1 47  ? 10.01244  -13.87428 -10.82615 1.000 7.95554  ? 128  THR A CA  1 
ATOM   494  C C   . THR A 1 47  ? 11.08367  -12.97245 -10.23039 1.000 7.37927  ? 128  THR A C   1 
ATOM   495  O O   . THR A 1 47  ? 12.16902  -13.45103 -9.87854  1.000 8.61802  ? 128  THR A O   1 
ATOM   496  C CB  . THR A 1 47  ? 9.62643   -14.90782 -9.76850  1.000 9.56162  ? 128  THR A CB  1 
ATOM   497  O OG1 . THR A 1 47  ? 8.50778   -15.66459 -10.23253 1.000 10.50105 ? 128  THR A OG1 1 
ATOM   498  C CG2 . THR A 1 47  ? 9.28380   -14.23514 -8.43532  1.000 10.38592 ? 128  THR A CG2 1 
ATOM   499  N N   . TRP A 1 48  ? 10.77644  -11.68847 -10.07979 1.000 7.38388  ? 129  TRP A N   1 
ATOM   500  C CA  . TRP A 1 48  ? 11.74639  -10.72950 -9.57150  1.000 7.56576  ? 129  TRP A CA  1 
ATOM   501  C C   . TRP A 1 48  ? 11.64499  -10.63613 -8.05600  1.000 7.45311  ? 129  TRP A C   1 
ATOM   502  O O   . TRP A 1 48  ? 10.62671  -10.18763 -7.51440  1.000 9.02658  ? 129  TRP A O   1 
ATOM   503  C CB  . TRP A 1 48  ? 11.53798  -9.36453  -10.22046 1.000 8.18924  ? 129  TRP A CB  1 
ATOM   504  C CG  . TRP A 1 48  ? 11.95120  -9.34424  -11.65741 1.000 7.95425  ? 129  TRP A CG  1 
ATOM   505  C CD1 . TRP A 1 48  ? 11.45834  -10.11474 -12.66903 1.000 8.11918  ? 129  TRP A CD1 1 
ATOM   506  C CD2 . TRP A 1 48  ? 12.96508  -8.51743  -12.24325 1.000 8.36158  ? 129  TRP A CD2 1 
ATOM   507  N NE1 . TRP A 1 48  ? 12.09943  -9.81420  -13.84268 1.000 8.20708  ? 129  TRP A NE1 1 
ATOM   508  C CE2 . TRP A 1 48  ? 13.03210  -8.84031  -13.60895 1.000 7.90344  ? 129  TRP A CE2 1 
ATOM   509  C CE3 . TRP A 1 48  ? 13.81912  -7.52445  -11.74063 1.000 8.74948  ? 129  TRP A CE3 1 
ATOM   510  C CZ2 . TRP A 1 48  ? 13.91185  -8.20420  -14.48650 1.000 8.59364  ? 129  TRP A CZ2 1 
ATOM   511  C CZ3 . TRP A 1 48  ? 14.69314  -6.89881  -12.60581 1.000 8.93948  ? 129  TRP A CZ3 1 
ATOM   512  C CH2 . TRP A 1 48  ? 14.73484  -7.24112  -13.96570 1.000 8.83244  ? 129  TRP A CH2 1 
ATOM   513  N N   . LEU A 1 49  ? 12.71141  -11.04187 -7.37294  1.000 7.19116  ? 130  LEU A N   1 
ATOM   514  C CA  . LEU A 1 49  ? 12.78779  -10.90239 -5.91944  1.000 8.03120  ? 130  LEU A CA  1 
ATOM   515  C C   . LEU A 1 49  ? 13.39237  -9.53193  -5.62018  1.000 7.99240  ? 130  LEU A C   1 
ATOM   516  O O   . LEU A 1 49  ? 14.55733  -9.38253  -5.25068  1.000 9.20713  ? 130  LEU A O   1 
ATOM   517  C CB  . LEU A 1 49  ? 13.58965  -12.04102 -5.30473  1.000 8.29626  ? 130  LEU A CB  1 
ATOM   518  C CG  . LEU A 1 49  ? 13.09425  -13.44154 -5.67777  1.000 8.87871  ? 130  LEU A CG  1 
ATOM   519  C CD1 . LEU A 1 49  ? 13.96546  -14.50046 -5.03926  1.000 10.36413 ? 130  LEU A CD1 1 
ATOM   520  C CD2 . LEU A 1 49  ? 11.62233  -13.64366 -5.30407  1.000 10.07201 ? 130  LEU A CD2 1 
ATOM   521  N N   . ASP A 1 50  ? 12.57264  -8.50871  -5.82804  1.000 8.07388  ? 131  ASP A N   1 
ATOM   522  C CA  A ASP A 1 50  ? 12.99649  -7.11965  -5.74932  0.538 8.91270  ? 131  ASP A CA  1 
ATOM   523  C CA  B ASP A 1 50  ? 13.07407  -7.14513  -5.73207  0.462 8.99887  ? 131  ASP A CA  1 
ATOM   524  C C   . ASP A 1 50  ? 12.94748  -6.55641  -4.33588  1.000 9.36112  ? 131  ASP A C   1 
ATOM   525  O O   . ASP A 1 50  ? 13.27983  -5.38454  -4.14398  1.000 11.19979 ? 131  ASP A O   1 
ATOM   526  C CB  A ASP A 1 50  ? 12.19232  -6.23765  -6.72340  0.538 9.60568  ? 131  ASP A CB  1 
ATOM   527  C CB  B ASP A 1 50  ? 12.48052  -6.22700  -6.81459  0.462 11.35815 ? 131  ASP A CB  1 
ATOM   528  C CG  A ASP A 1 50  ? 10.69942  -6.18820  -6.40831  0.538 9.75302  ? 131  ASP A CG  1 
ATOM   529  C CG  B ASP A 1 50  ? 10.98667  -6.04980  -6.69075  0.462 12.49274 ? 131  ASP A CG  1 
ATOM   530  O OD1 A ASP A 1 50  ? 10.06980  -7.24412  -6.23089  0.538 11.35022 ? 131  ASP A OD1 1 
ATOM   531  O OD1 B ASP A 1 50  ? 10.35673  -6.75679  -5.88733  0.462 10.35969 ? 131  ASP A OD1 1 
ATOM   532  O OD2 A ASP A 1 50  ? 10.15299  -5.06534  -6.34592  0.538 15.26252 ? 131  ASP A OD2 1 
ATOM   533  O OD2 B ASP A 1 50  ? 10.43446  -5.18135  -7.40030  0.462 14.30637 ? 131  ASP A OD2 1 
ATOM   534  N N   . SER A 1 51  ? 12.53936  -7.35763  -3.35563  1.000 9.89485  ? 132  SER A N   1 
ATOM   535  C CA  . SER A 1 51  ? 12.49067  -6.94926  -1.95847  1.000 10.03080 ? 132  SER A CA  1 
ATOM   536  C C   . SER A 1 51  ? 12.38389  -8.20696  -1.10567  1.000 9.31736  ? 132  SER A C   1 
ATOM   537  O O   . SER A 1 51  ? 12.03831  -9.28112  -1.60089  1.000 9.18970  ? 132  SER A O   1 
ATOM   538  C CB  . SER A 1 51  ? 11.29106  -6.04224  -1.67988  1.000 11.25591 ? 132  SER A CB  1 
ATOM   539  O OG  . SER A 1 51  ? 10.09291  -6.79115  -1.71038  1.000 13.64109 ? 132  SER A OG  1 
ATOM   540  N N   . VAL A 1 52  ? 12.66700  -8.05217  0.19284   1.000 9.17754  ? 133  VAL A N   1 
ATOM   541  C CA  A VAL A 1 52  ? 12.49002  -9.14585  1.15354   0.712 9.07345  ? 133  VAL A CA  1 
ATOM   542  C CA  B VAL A 1 52  ? 12.49782  -9.17452  1.10999   0.288 9.15719  ? 133  VAL A CA  1 
ATOM   543  C C   . VAL A 1 52  ? 11.03649  -9.58421  1.19614   1.000 9.54891  ? 133  VAL A C   1 
ATOM   544  O O   . VAL A 1 52  ? 10.73109  -10.75459 1.45075   1.000 9.99028  ? 133  VAL A O   1 
ATOM   545  C CB  A VAL A 1 52  ? 13.01412  -8.71834  2.54469   0.712 9.06657  ? 133  VAL A CB  1 
ATOM   546  C CB  B VAL A 1 52  ? 13.10242  -8.86824  2.49310   0.288 10.27015 ? 133  VAL A CB  1 
ATOM   547  C CG1 A VAL A 1 52  ? 12.48890  -9.62815  3.66995   0.712 10.86796 ? 133  VAL A CG1 1 
ATOM   548  C CG1 B VAL A 1 52  ? 14.53795  -8.37059  2.34565   0.288 11.96457 ? 133  VAL A CG1 1 
ATOM   549  C CG2 A VAL A 1 52  ? 14.53236  -8.73222  2.55836   0.712 9.19221  ? 133  VAL A CG2 1 
ATOM   550  C CG2 B VAL A 1 52  ? 12.24895  -7.87723  3.22270   0.288 11.64326 ? 133  VAL A CG2 1 
ATOM   551  N N   . ALA A 1 53  ? 10.11773  -8.65375  0.93262   1.000 10.55834 ? 134  ALA A N   1 
ATOM   552  C CA  . ALA A 1 53  ? 8.70067   -8.97970  0.92106   1.000 11.29440 ? 134  ALA A CA  1 
ATOM   553  C C   . ALA A 1 53  ? 8.33652   -10.04055 -0.11177  1.000 10.86559 ? 134  ALA A C   1 
ATOM   554  O O   . ALA A 1 53  ? 7.23530   -10.58336 -0.03365  1.000 13.27712 ? 134  ALA A O   1 
ATOM   555  C CB  . ALA A 1 53  ? 7.85627   -7.71607  0.73643   1.000 13.38094 ? 134  ALA A CB  1 
ATOM   556  N N   A LYS A 1 54  ? 9.15308   -10.19675 -1.16546  0.841 8.63968  ? 135  LYS A N   1 
ATOM   557  N N   B LYS A 1 54  ? 9.27587   -10.50278 -0.94190  0.159 9.54055  ? 135  LYS A N   1 
ATOM   558  C CA  A LYS A 1 54  ? 8.90012   -11.18866 -2.20071  0.841 9.88833  ? 135  LYS A CA  1 
ATOM   559  C CA  B LYS A 1 54  ? 8.97957   -11.57969 -1.88974  0.159 9.54895  ? 135  LYS A CA  1 
ATOM   560  C C   A LYS A 1 54  ? 9.36081   -12.58319 -1.80642  0.841 8.03732  ? 135  LYS A C   1 
ATOM   561  C C   B LYS A 1 54  ? 9.52116   -12.95657 -1.49688  0.159 6.61310  ? 135  LYS A C   1 
ATOM   562  O O   A LYS A 1 54  ? 9.03968   -13.54366 -2.51113  0.841 8.70194  ? 135  LYS A O   1 
ATOM   563  O O   B LYS A 1 54  ? 9.16703   -13.94475 -2.15214  0.159 6.88590  ? 135  LYS A O   1 
ATOM   564  C CB  A LYS A 1 54  ? 9.58011   -10.78987 -3.51827  0.841 9.23345  ? 135  LYS A CB  1 
ATOM   565  C CB  B LYS A 1 54  ? 9.49460   -11.22543 -3.28568  0.159 11.39011 ? 135  LYS A CB  1 
ATOM   566  C CG  A LYS A 1 54  ? 9.06275   -9.50743  -4.12343  0.841 10.46524 ? 135  LYS A CG  1 
ATOM   567  C CG  B LYS A 1 54  ? 9.68012   -9.74853  -3.49562  0.159 13.62287 ? 135  LYS A CG  1 
ATOM   568  C CD  A LYS A 1 54  ? 7.72995   -9.71105  -4.83029  0.841 14.39704 ? 135  LYS A CD  1 
ATOM   569  C CD  B LYS A 1 54  ? 9.21858   -9.34704  -4.86739  0.159 11.78448 ? 135  LYS A CD  1 
ATOM   570  C CE  A LYS A 1 54  ? 7.29963   -8.48479  -5.63121  0.841 16.88215 ? 135  LYS A CE  1 
ATOM   571  C CE  B LYS A 1 54  ? 7.79229   -8.84710  -4.84140  0.159 15.89318 ? 135  LYS A CE  1 
ATOM   572  N NZ  A LYS A 1 54  ? 6.40069   -8.82898  -6.76655  0.841 16.92424 ? 135  LYS A NZ  1 
ATOM   573  N NZ  B LYS A 1 54  ? 7.54442   -7.86496  -5.93220  0.159 14.58667 ? 135  LYS A NZ  1 
ATOM   574  N N   A ILE A 1 55  ? 10.12429  -12.72567 -0.72964  0.841 7.94388  ? 136  ILE A N   1 
ATOM   575  N N   B ILE A 1 55  ? 10.37641  -13.05086 -0.47149  0.159 5.98716  ? 136  ILE A N   1 
ATOM   576  C CA  A ILE A 1 55  ? 10.71759  -14.02035 -0.39787  0.841 7.78265  ? 136  ILE A CA  1 
ATOM   577  C CA  B ILE A 1 55  ? 10.98235  -14.34053 -0.11685  0.159 7.11217  ? 136  ILE A CA  1 
ATOM   578  C C   A ILE A 1 55  ? 9.65952   -15.04819 -0.00075  0.841 8.54203  ? 136  ILE A C   1 
ATOM   579  C C   B ILE A 1 55  ? 9.94895   -15.42252 0.18491   0.159 6.28856  ? 136  ILE A C   1 
ATOM   580  O O   A ILE A 1 55  ? 9.75788   -16.20631 -0.42261  0.841 8.81122  ? 136  ILE A O   1 
ATOM   581  O O   B ILE A 1 55  ? 10.11713  -16.55527 -0.29404  0.159 6.18794  ? 136  ILE A O   1 
ATOM   582  C CB  A ILE A 1 55  ? 11.86925  -13.86826 0.61101   0.841 8.19008  ? 136  ILE A CB  1 
ATOM   583  C CB  B ILE A 1 55  ? 12.02863  -14.15947 0.99268   0.159 8.12495  ? 136  ILE A CB  1 
ATOM   584  C CG1 A ILE A 1 55  ? 12.97920  -13.00800 0.00446   0.841 7.49333  ? 136  ILE A CG1 1 
ATOM   585  C CG1 B ILE A 1 55  ? 13.22165  -13.33821 0.50094   0.159 8.85408  ? 136  ILE A CG1 1 
ATOM   586  C CG2 A ILE A 1 55  ? 12.40981  -15.22075 1.03110   0.841 8.98116  ? 136  ILE A CG2 1 
ATOM   587  C CG2 B ILE A 1 55  ? 12.50428  -15.50667 1.52062   0.159 10.14600 ? 136  ILE A CG2 1 
ATOM   588  C CD1 A ILE A 1 55  ? 14.10532  -12.69112 0.96432   0.841 8.57588  ? 136  ILE A CD1 1 
ATOM   589  C CD1 B ILE A 1 55  ? 13.80190  -12.42187 1.56207   0.159 10.39170 ? 136  ILE A CD1 1 
ATOM   590  N N   A PRO A 1 56  ? 8.61886   -14.69370 0.76108   0.841 8.47868  ? 137  PRO A N   1 
ATOM   591  N N   B PRO A 1 56  ? 8.88758   -15.16914 0.96318   0.159 5.87687  ? 137  PRO A N   1 
ATOM   592  C CA  A PRO A 1 56  ? 7.56427   -15.68737 1.01283   0.841 8.68937  ? 137  PRO A CA  1 
ATOM   593  C CA  B PRO A 1 56  ? 7.88995   -16.22526 1.18661   0.159 5.14531  ? 137  PRO A CA  1 
ATOM   594  C C   A PRO A 1 56  ? 6.92629   -16.21482 -0.26273  0.841 8.24591  ? 137  PRO A C   1 
ATOM   595  C C   B PRO A 1 56  ? 7.19694   -16.66312 -0.08719  0.159 6.41217  ? 137  PRO A C   1 
ATOM   596  O O   A PRO A 1 56  ? 6.60493   -17.41025 -0.33497  0.841 8.26994  ? 137  PRO A O   1 
ATOM   597  O O   B PRO A 1 56  ? 6.87948   -17.84922 -0.24316  0.159 5.32333  ? 137  PRO A O   1 
ATOM   598  C CB  A PRO A 1 56  ? 6.58935   -14.92925 1.92702   0.841 10.34448 ? 137  PRO A CB  1 
ATOM   599  C CB  B PRO A 1 56  ? 6.90451   -15.57564 2.16332   0.159 6.31620  ? 137  PRO A CB  1 
ATOM   600  C CG  A PRO A 1 56  ? 7.45723   -13.94257 2.63607   0.841 10.99343 ? 137  PRO A CG  1 
ATOM   601  C CG  B PRO A 1 56  ? 7.68089   -14.52511 2.84634   0.159 5.53332  ? 137  PRO A CG  1 
ATOM   602  C CD  A PRO A 1 56  ? 8.43666   -13.49697 1.60464   0.841 8.40507  ? 137  PRO A CD  1 
ATOM   603  C CD  B PRO A 1 56  ? 8.66446   -14.01274 1.85134   0.159 5.00121  ? 137  PRO A CD  1 
ATOM   604  N N   A ASP A 1 57  ? 6.76641   -15.36988 -1.28431  0.841 9.02080  ? 138  ASP A N   1 
ATOM   605  N N   B ASP A 1 57  ? 6.93830   -15.72011 -0.99675  0.159 8.28571  ? 138  ASP A N   1 
ATOM   606  C CA  A ASP A 1 57  ? 6.29590   -15.84701 -2.58193  0.841 9.18337  ? 138  ASP A CA  1 
ATOM   607  C CA  B ASP A 1 57  ? 6.32250   -16.06656 -2.26940  0.159 8.37470  ? 138  ASP A CA  1 
ATOM   608  C C   A ASP A 1 57  ? 7.22724   -16.91878 -3.14778  0.841 8.65547  ? 138  ASP A C   1 
ATOM   609  C C   B ASP A 1 57  ? 7.21630   -17.02336 -3.04296  0.159 8.75696  ? 138  ASP A C   1 
ATOM   610  O O   A ASP A 1 57  ? 6.76358   -17.94412 -3.65890  0.841 9.08062  ? 138  ASP A O   1 
ATOM   611  O O   B ASP A 1 57  ? 6.73647   -17.99921 -3.62748  0.159 9.04755  ? 138  ASP A O   1 
ATOM   612  C CB  A ASP A 1 57  ? 6.21387   -14.68653 -3.57962  0.841 9.82718  ? 138  ASP A CB  1 
ATOM   613  C CB  B ASP A 1 57  ? 6.06359   -14.79785 -3.08037  0.159 12.31713 ? 138  ASP A CB  1 
ATOM   614  C CG  A ASP A 1 57  ? 5.01602   -13.78546 -3.37567  0.841 11.19549 ? 138  ASP A CG  1 
ATOM   615  C CG  B ASP A 1 57  ? 4.63734   -14.28459 -2.92970  0.159 14.51619 ? 138  ASP A CG  1 
ATOM   616  O OD1 A ASP A 1 57  ? 4.08126   -14.15829 -2.63536  0.841 15.40541 ? 138  ASP A OD1 1 
ATOM   617  O OD1 B ASP A 1 57  ? 3.72893   -15.08988 -2.64411  0.159 10.37846 ? 138  ASP A OD1 1 
ATOM   618  O OD2 A ASP A 1 57  ? 5.03106   -12.68503 -3.97547  0.841 14.42638 ? 138  ASP A OD2 1 
ATOM   619  O OD2 B ASP A 1 57  ? 4.42763   -13.06110 -3.09079  0.159 13.83253 ? 138  ASP A OD2 1 
ATOM   620  N N   A LEU A 1 58  ? 8.54663   -16.68313 -3.09327  0.841 9.34773  ? 139  LEU A N   1 
ATOM   621  N N   B LEU A 1 58  ? 8.52747   -16.77523 -3.03030  0.159 9.46141  ? 139  LEU A N   1 
ATOM   622  C CA  A LEU A 1 58  ? 9.49849   -17.69254 -3.56255  0.841 9.22636  ? 139  LEU A CA  1 
ATOM   623  C CA  B LEU A 1 58  ? 9.46014   -17.72165 -3.63101  0.159 9.19056  ? 139  LEU A CA  1 
ATOM   624  C C   A LEU A 1 58  ? 9.23750   -19.03297 -2.89618  0.841 7.61267  ? 139  LEU A C   1 
ATOM   625  C C   B LEU A 1 58  ? 9.35581   -19.09112 -2.96384  0.159 7.78011  ? 139  LEU A C   1 
ATOM   626  O O   A LEU A 1 58  ? 9.19355   -20.07389 -3.56011  0.841 8.21783  ? 139  LEU A O   1 
ATOM   627  O O   B LEU A 1 58  ? 9.36515   -20.12317 -3.64378  0.159 8.71172  ? 139  LEU A O   1 
ATOM   628  C CB  A LEU A 1 58  ? 10.94074  -17.25122 -3.29740  0.841 9.27051  ? 139  LEU A CB  1 
ATOM   629  C CB  B LEU A 1 58  ? 10.88292  -17.16510 -3.56517  0.159 10.49727 ? 139  LEU A CB  1 
ATOM   630  C CG  A LEU A 1 58  ? 12.00147  -18.34723 -3.50544  0.841 9.02494  ? 139  LEU A CG  1 
ATOM   631  C CG  B LEU A 1 58  ? 12.00107  -18.03822 -2.99127  0.159 11.26033 ? 139  LEU A CG  1 
ATOM   632  C CD1 A LEU A 1 58  ? 12.07347  -18.76927 -4.96742  0.841 10.85156 ? 139  LEU A CD1 1 
ATOM   633  C CD1 B LEU A 1 58  ? 12.78680  -18.70293 -4.11357  0.159 12.93354 ? 139  LEU A CD1 1 
ATOM   634  C CD2 A LEU A 1 58  ? 13.35948  -17.87140 -2.99418  0.841 10.69356 ? 139  LEU A CD2 1 
ATOM   635  C CD2 B LEU A 1 58  ? 12.92407  -17.22365 -2.09699  0.159 11.67221 ? 139  LEU A CD2 1 
ATOM   636  N N   A GLY A 1 59  ? 9.07695   -19.02537 -1.57317  0.841 8.03162  ? 140  GLY A N   1 
ATOM   637  N N   B GLY A 1 59  ? 9.22302   -19.12049 -1.63533  0.159 7.52902  ? 140  GLY A N   1 
ATOM   638  C CA  A GLY A 1 59  ? 8.79229   -20.26675 -0.87873  0.841 7.82954  ? 140  GLY A CA  1 
ATOM   639  C CA  B GLY A 1 59  ? 9.07223   -20.39474 -0.94651  0.159 8.02240  ? 140  GLY A CA  1 
ATOM   640  C C   A GLY A 1 59  ? 7.56083   -20.96951 -1.42033  0.841 7.83481  ? 140  GLY A C   1 
ATOM   641  C C   B GLY A 1 59  ? 7.81752   -21.13722 -1.36301  0.159 6.33305  ? 140  GLY A C   1 
ATOM   642  O O   A GLY A 1 59  ? 7.56695   -22.18954 -1.62973  0.841 8.23507  ? 140  GLY A O   1 
ATOM   643  O O   B GLY A 1 59  ? 7.83507   -22.35532 -1.56338  0.159 7.35259  ? 140  GLY A O   1 
ATOM   644  N N   A THR A 1 60  ? 6.48389   -20.21249 -1.66540  0.841 7.45571  ? 141  THR A N   1 
ATOM   645  N N   B THR A 1 60  ? 6.70637   -20.40977 -1.49257  0.159 5.99358  ? 141  THR A N   1 
ATOM   646  C CA  A THR A 1 60  ? 5.29495   -20.85689 -2.21150  0.841 7.49578  ? 141  THR A CA  1 
ATOM   647  C CA  B THR A 1 60  ? 5.48648   -21.01197 -2.02005  0.159 6.36723  ? 141  THR A CA  1 
ATOM   648  C C   A THR A 1 60  ? 5.54727   -21.43195 -3.59811  0.841 7.46769  ? 141  THR A C   1 
ATOM   649  C C   B THR A 1 60  ? 5.69450   -21.49787 -3.44670  0.159 6.72727  ? 141  THR A C   1 
ATOM   650  O O   A THR A 1 60  ? 4.99561   -22.47882 -3.93992  0.841 8.03985  ? 141  THR A O   1 
ATOM   651  O O   B THR A 1 60  ? 5.29206   -22.61246 -3.79729  0.159 6.64537  ? 141  THR A O   1 
ATOM   652  C CB  A THR A 1 60  ? 4.04519   -19.95873 -2.20429  0.841 7.47800  ? 141  THR A CB  1 
ATOM   653  C CB  B THR A 1 60  ? 4.31837   -20.01899 -1.96342  0.159 7.81100  ? 141  THR A CB  1 
ATOM   654  O OG1 A THR A 1 60  ? 4.13917   -18.91601 -3.18521  0.841 9.32663  ? 141  THR A OG1 1 
ATOM   655  O OG1 B THR A 1 60  ? 4.47211   -19.02647 -2.98918  0.159 12.15817 ? 141  THR A OG1 1 
ATOM   656  C CG2 A THR A 1 60  ? 3.73473   -19.41869 -0.82515  0.841 8.32928  ? 141  THR A CG2 1 
ATOM   657  C CG2 B THR A 1 60  ? 4.22122   -19.34768 -0.60361  0.159 11.52869 ? 141  THR A CG2 1 
ATOM   658  N N   A TYR A 1 61  ? 6.35625   -20.76408 -4.42088  0.841 7.13040  ? 142  TYR A N   1 
ATOM   659  N N   B TYR A 1 61  ? 6.31320   -20.66120 -4.28489  0.159 7.73467  ? 142  TYR A N   1 
ATOM   660  C CA  A TYR A 1 61  ? 6.57884   -21.25793 -5.77761  0.841 7.68563  ? 142  TYR A CA  1 
ATOM   661  C CA  B TYR A 1 61  ? 6.56513   -21.02689 -5.67377  0.159 7.37191  ? 142  TYR A CA  1 
ATOM   662  C C   A TYR A 1 61  ? 7.39744   -22.54548 -5.75722  0.841 7.68284  ? 142  TYR A C   1 
ATOM   663  C C   B TYR A 1 61  ? 7.35697   -22.32289 -5.75489  0.159 8.21970  ? 142  TYR A C   1 
ATOM   664  O O   A TYR A 1 61  ? 7.10715   -23.48786 -6.50395  0.841 7.78401  ? 142  TYR A O   1 
ATOM   665  O O   B TYR A 1 61  ? 7.07228   -23.18315 -6.59575  0.159 7.71941  ? 142  TYR A O   1 
ATOM   666  C CB  A TYR A 1 61  ? 7.27154   -20.18213 -6.62593  0.841 8.17949  ? 142  TYR A CB  1 
ATOM   667  C CB  B TYR A 1 61  ? 7.33294   -19.89535 -6.35575  0.159 9.12589  ? 142  TYR A CB  1 
ATOM   668  C CG  A TYR A 1 61  ? 6.50224   -18.85889 -6.75130  0.841 9.20197  ? 142  TYR A CG  1 
ATOM   669  C CG  B TYR A 1 61  ? 6.45298   -18.75654 -6.80634  0.159 9.28350  ? 142  TYR A CG  1 
ATOM   670  C CD1 A TYR A 1 61  ? 5.16057   -18.75671 -6.40263  0.841 8.60092  ? 142  TYR A CD1 1 
ATOM   671  C CD1 B TYR A 1 61  ? 5.29291   -18.44005 -6.11534  0.159 10.50510 ? 142  TYR A CD1 1 
ATOM   672  C CD2 A TYR A 1 61  ? 7.14310   -17.69483 -7.16002  0.841 11.00681 ? 142  TYR A CD2 1 
ATOM   673  C CD2 B TYR A 1 61  ? 6.81207   -17.95911 -7.87863  0.159 7.53043  ? 142  TYR A CD2 1 
ATOM   674  C CE1 A TYR A 1 61  ? 4.47821   -17.53536 -6.48376  0.841 11.12058 ? 142  TYR A CE1 1 
ATOM   675  C CE1 B TYR A 1 61  ? 4.49843   -17.39893 -6.49855  0.159 10.93484 ? 142  TYR A CE1 1 
ATOM   676  C CE2 A TYR A 1 61  ? 6.46929   -16.47443 -7.23991  0.841 12.98698 ? 142  TYR A CE2 1 
ATOM   677  C CE2 B TYR A 1 61  ? 6.01679   -16.90614 -8.27335  0.159 12.26510 ? 142  TYR A CE2 1 
ATOM   678  C CZ  A TYR A 1 61  ? 5.14164   -16.39911 -6.89541  0.841 11.39162 ? 142  TYR A CZ  1 
ATOM   679  C CZ  B TYR A 1 61  ? 4.86113   -16.63578 -7.57346  0.159 10.13479 ? 142  TYR A CZ  1 
ATOM   680  O OH  A TYR A 1 61  ? 4.48196   -15.18520 -6.96535  0.841 13.70593 ? 142  TYR A OH  1 
ATOM   681  O OH  B TYR A 1 61  ? 4.05341   -15.59928 -7.93907  0.159 12.64373 ? 142  TYR A OH  1 
ATOM   682  N N   A LEU A 1 62  ? 8.41885   -22.60581 -4.90504  0.841 7.59615  ? 143  LEU A N   1 
ATOM   683  N N   B LEU A 1 62  ? 8.34944   -22.48036 -4.87589  0.159 7.56734  ? 143  LEU A N   1 
ATOM   684  C CA  A LEU A 1 62  ? 9.21149   -23.82425 -4.78592  0.841 8.03485  ? 143  LEU A CA  1 
ATOM   685  C CA  B LEU A 1 62  ? 9.12400   -23.71598 -4.81531  0.159 8.19070  ? 143  LEU A CA  1 
ATOM   686  C C   A LEU A 1 62  ? 8.34630   -24.99082 -4.33947  0.841 7.88547  ? 143  LEU A C   1 
ATOM   687  C C   B LEU A 1 62  ? 8.23639   -24.89890 -4.43987  0.159 7.72380  ? 143  LEU A C   1 
ATOM   688  O O   A LEU A 1 62  ? 8.43427   -26.09005 -4.89513  0.841 8.21104  ? 143  LEU A O   1 
ATOM   689  O O   B LEU A 1 62  ? 8.21026   -25.92051 -5.13725  0.159 7.31063  ? 143  LEU A O   1 
ATOM   690  C CB  A LEU A 1 62  ? 10.36686  -23.60567 -3.81083  0.841 8.20312  ? 143  LEU A CB  1 
ATOM   691  C CB  B LEU A 1 62  ? 10.25389  -23.55531 -3.79240  0.159 8.35153  ? 143  LEU A CB  1 
ATOM   692  C CG  A LEU A 1 62  ? 11.39812  -22.57137 -4.24632  0.841 8.39234  ? 143  LEU A CG  1 
ATOM   693  C CG  B LEU A 1 62  ? 11.38504  -22.55227 -4.05357  0.159 8.71628  ? 143  LEU A CG  1 
ATOM   694  C CD1 A LEU A 1 62  ? 12.28722  -22.22846 -3.07277  0.841 9.97509  ? 143  LEU A CD1 1 
ATOM   695  C CD1 B LEU A 1 62  ? 11.94246  -22.00158 -2.73952  0.159 10.23053 ? 143  LEU A CD1 1 
ATOM   696  C CD2 A LEU A 1 62  ? 12.20838  -23.03486 -5.43730  0.841 9.55509  ? 143  LEU A CD2 1 
ATOM   697  C CD2 B LEU A 1 62  ? 12.49652  -23.17814 -4.88230  0.159 8.99994  ? 143  LEU A CD2 1 
ATOM   698  N N   . ALA A 1 63  ? 7.49835   -24.77155 -3.33255  1.000 7.87601  ? 144  ALA A N   1 
ATOM   699  C CA  . ALA A 1 63  ? 6.65627   -25.86028 -2.84150  1.000 8.74452  ? 144  ALA A CA  1 
ATOM   700  C C   . ALA A 1 63  ? 5.60739   -26.26880 -3.86951  1.000 8.64352  ? 144  ALA A C   1 
ATOM   701  O O   . ALA A 1 63  ? 5.29978   -27.45697 -4.02219  1.000 8.74557  ? 144  ALA A O   1 
ATOM   702  C CB  . ALA A 1 63  ? 5.98668   -25.43630 -1.53729  1.000 9.24658  ? 144  ALA A CB  1 
ATOM   703  N N   . SER A 1 64  ? 5.03029   -25.29410 -4.56872  1.000 8.01763  ? 145  SER A N   1 
ATOM   704  C CA  . SER A 1 64  ? 4.05427   -25.60968 -5.60205  1.000 8.51242  ? 145  SER A CA  1 
ATOM   705  C C   . SER A 1 64  ? 4.71218   -26.38881 -6.72229  1.000 8.25147  ? 145  SER A C   1 
ATOM   706  O O   . SER A 1 64  ? 4.14762   -27.36646 -7.22388  1.000 8.96991  ? 145  SER A O   1 
ATOM   707  C CB  . SER A 1 64  ? 3.43605   -24.32020 -6.15565  1.000 8.52469  ? 145  SER A CB  1 
ATOM   708  O OG  . SER A 1 64  ? 2.70131   -23.63275 -5.16779  1.000 9.81161  ? 145  SER A OG  1 
ATOM   709  N N   A ALA A 1 65  ? 5.85800   -25.90371 -7.19658  0.708 8.20450  ? 146  ALA A N   1 
ATOM   710  N N   B ALA A 1 65  ? 5.96647   -26.04315 -7.04387  0.292 7.23625  ? 146  ALA A N   1 
ATOM   711  C CA  A ALA A 1 65  ? 6.56537   -26.58970 -8.26785  0.708 8.32331  ? 146  ALA A CA  1 
ATOM   712  C CA  B ALA A 1 65  ? 6.72147   -26.76261 -8.06661  0.292 8.22485  ? 146  ALA A CA  1 
ATOM   713  C C   A ALA A 1 65  ? 6.85558   -28.03103 -7.87999  0.708 8.25630  ? 146  ALA A C   1 
ATOM   714  C C   B ALA A 1 65  ? 7.12074   -28.15391 -7.59201  0.292 6.99539  ? 146  ALA A C   1 
ATOM   715  O O   A ALA A 1 65  ? 6.65581   -28.94695 -8.68294  0.708 8.06679  ? 146  ALA A O   1 
ATOM   716  O O   B ALA A 1 65  ? 7.07237   -29.11297 -8.36806  0.292 7.27081  ? 146  ALA A O   1 
ATOM   717  C CB  A ALA A 1 65  ? 7.85131   -25.83263 -8.59715  0.708 8.59531  ? 146  ALA A CB  1 
ATOM   718  C CB  B ALA A 1 65  ? 7.96162   -25.95910 -8.46211  0.292 7.86393  ? 146  ALA A CB  1 
ATOM   719  N N   A SER A 1 66  ? 7.29953   -28.25498 -6.64171  0.708 7.84106  ? 147  SER A N   1 
ATOM   720  N N   B SER A 1 66  ? 7.53678   -28.28203 -6.33028  0.292 8.34096  ? 147  SER A N   1 
ATOM   721  C CA  A SER A 1 66  ? 7.59849   -29.61307 -6.20061  0.708 8.54980  ? 147  SER A CA  1 
ATOM   722  C CA  B SER A 1 66  ? 7.90319   -29.59353 -5.80260  0.292 8.43077  ? 147  SER A CA  1 
ATOM   723  C C   A SER A 1 66  ? 6.37804   -30.51696 -6.33386  0.708 7.79938  ? 147  SER A C   1 
ATOM   724  C C   B SER A 1 66  ? 6.74404   -30.57287 -5.92519  0.292 8.60199  ? 147  SER A C   1 
ATOM   725  O O   A SER A 1 66  ? 6.48096   -31.64983 -6.81884  0.708 8.40275  ? 147  SER A O   1 
ATOM   726  O O   B SER A 1 66  ? 6.92014   -31.71218 -6.37097  0.292 9.47695  ? 147  SER A O   1 
ATOM   727  C CB  A SER A 1 66  ? 8.09420   -29.58087 -4.75383  0.708 8.40436  ? 147  SER A CB  1 
ATOM   728  C CB  B SER A 1 66  ? 8.35511   -29.46763 -4.34626  0.292 10.10195 ? 147  SER A CB  1 
ATOM   729  O OG  A SER A 1 66  ? 8.42619   -30.87256 -4.27457  0.708 10.62100 ? 147  SER A OG  1 
ATOM   730  O OG  B SER A 1 66  ? 8.94158   -30.67551 -3.88586  0.292 11.15902 ? 147  SER A OG  1 
ATOM   731  N N   A ALA A 1 67  ? 5.20820   -30.02514 -5.91772  0.708 8.74285  ? 148  ALA A N   1 
ATOM   732  N N   B ALA A 1 67  ? 5.54019   -30.13317 -5.55226  0.292 8.11474  ? 148  ALA A N   1 
ATOM   733  C CA  A ALA A 1 67  ? 3.99007   -30.82723 -5.99247  0.708 8.01168  ? 148  ALA A CA  1 
ATOM   734  C CA  B ALA A 1 67  ? 4.37114   -31.00408 -5.61823  0.292 7.94839  ? 148  ALA A CA  1 
ATOM   735  C C   A ALA A 1 67  ? 3.53915   -31.02620 -7.43482  0.708 8.00017  ? 148  ALA A C   1 
ATOM   736  C C   B ALA A 1 67  ? 3.94442   -31.26465 -7.05784  0.292 8.29572  ? 148  ALA A C   1 
ATOM   737  O O   A ALA A 1 67  ? 3.07558   -32.11247 -7.79639  0.708 8.76410  ? 148  ALA A O   1 
ATOM   738  O O   B ALA A 1 67  ? 3.51860   -32.37658 -7.38922  0.292 8.32755  ? 148  ALA A O   1 
ATOM   739  C CB  A ALA A 1 67  ? 2.88898   -30.17928 -5.15427  0.708 9.12663  ? 148  ALA A CB  1 
ATOM   740  C CB  B ALA A 1 67  ? 3.21997   -30.39677 -4.81746  0.292 8.05578  ? 148  ALA A CB  1 
ATOM   741  N N   A LEU A 1 68  ? 3.64367   -29.98861 -8.26976  0.708 7.88920  ? 149  LEU A N   1 
ATOM   742  N N   B LEU A 1 68  ? 4.03706   -30.25401 -7.92644  0.292 7.64259  ? 149  LEU A N   1 
ATOM   743  C CA  A LEU A 1 68  ? 3.26681   -30.14071 -9.67135  0.708 8.37541  ? 149  LEU A CA  1 
ATOM   744  C CA  B LEU A 1 68  ? 3.67425   -30.46379 -9.32325  0.292 8.54200  ? 149  LEU A CA  1 
ATOM   745  C C   A LEU A 1 68  ? 4.13312   -31.18449 -10.35472 0.708 8.93511  ? 149  LEU A C   1 
ATOM   746  C C   B LEU A 1 68  ? 4.58363   -31.49439 -9.97466  0.292 8.57434  ? 149  LEU A C   1 
ATOM   747  O O   A LEU A 1 68  ? 3.64198   -31.96642 -11.18048 0.708 9.54925  ? 149  LEU A O   1 
ATOM   748  O O   B LEU A 1 68  ? 4.12306   -32.34116 -10.74956 0.292 8.90278  ? 149  LEU A O   1 
ATOM   749  C CB  A LEU A 1 68  ? 3.37915   -28.81019 -10.41512 0.708 8.93521  ? 149  LEU A CB  1 
ATOM   750  C CB  B LEU A 1 68  ? 3.70529   -29.14353 -10.09145 0.292 8.31095  ? 149  LEU A CB  1 
ATOM   751  C CG  A LEU A 1 68  ? 2.42433   -27.67974 -10.03964 0.708 11.60273 ? 149  LEU A CG  1 
ATOM   752  C CG  B LEU A 1 68  ? 3.06868   -29.22833 -11.47625 0.292 12.41683 ? 149  LEU A CG  1 
ATOM   753  C CD1 A LEU A 1 68  ? 2.71850   -26.44550 -10.88179 0.708 13.58615 ? 149  LEU A CD1 1 
ATOM   754  C CD1 B LEU A 1 68  ? 1.62899   -29.67694 -11.33861 0.292 15.69762 ? 149  LEU A CD1 1 
ATOM   755  C CD2 A LEU A 1 68  ? 0.97132   -28.09788 -10.19600 0.708 12.46341 ? 149  LEU A CD2 1 
ATOM   756  C CD2 B LEU A 1 68  ? 3.13043   -27.88867 -12.16392 0.292 14.66733 ? 149  LEU A CD2 1 
ATOM   757  N N   A GLY A 1 69  ? 5.42816   -31.19828 -10.03578 0.708 8.36201  ? 150  GLY A N   1 
ATOM   758  N N   B GLY A 1 69  ? 5.87711   -31.45365 -9.65637  0.292 8.04350  ? 150  GLY A N   1 
ATOM   759  C CA  A GLY A 1 69  ? 6.30944   -32.19872 -10.61199 0.708 8.72720  ? 150  GLY A CA  1 
ATOM   760  C CA  B GLY A 1 69  ? 6.77692   -32.46686 -10.17646 0.292 7.23693  ? 150  GLY A CA  1 
ATOM   761  C C   A GLY A 1 69  ? 5.90236   -33.60842 -10.23559 0.708 9.47022  ? 150  GLY A C   1 
ATOM   762  C C   B GLY A 1 69  ? 6.41797   -33.85728 -9.69291  0.292 8.42010  ? 150  GLY A C   1 
ATOM   763  O O   A GLY A 1 69  ? 5.84101   -34.49836 -11.08832 0.708 10.71198 ? 150  GLY A O   1 
ATOM   764  O O   B GLY A 1 69  ? 6.41882   -34.81558 -10.47068 0.292 9.50154  ? 150  GLY A O   1 
ATOM   765  N N   A LYS A 1 70  ? 5.60027   -33.82784 -8.95273  0.708 9.35312  ? 151  LYS A N   1 
ATOM   766  N N   B LYS A 1 70  ? 6.09462   -33.98196 -8.40255  0.292 10.77037 ? 151  LYS A N   1 
ATOM   767  C CA  A LYS A 1 70  ? 5.18288   -35.15727 -8.52180  0.708 11.14868 ? 151  LYS A CA  1 
ATOM   768  C CA  B LYS A 1 70  ? 5.73439   -35.28013 -7.84094  0.292 13.28860 ? 151  LYS A CA  1 
ATOM   769  C C   A LYS A 1 70  ? 3.87008   -35.57253 -9.17627  0.708 11.12574 ? 151  LYS A C   1 
ATOM   770  C C   B LYS A 1 70  ? 4.48553   -35.85018 -8.50847  0.292 12.03420 ? 151  LYS A C   1 
ATOM   771  O O   A LYS A 1 70  ? 3.68479   -36.75135 -9.50551  0.708 14.18077 ? 151  LYS A O   1 
ATOM   772  O O   B LYS A 1 70  ? 4.40854   -37.05659 -8.76849  0.292 14.66373 ? 151  LYS A O   1 
ATOM   773  C CB  A LYS A 1 70  ? 5.10898   -35.23734 -6.99196  0.708 12.51818 ? 151  LYS A CB  1 
ATOM   774  C CB  B LYS A 1 70  ? 5.52058   -35.14752 -6.33112  0.292 13.32995 ? 151  LYS A CB  1 
ATOM   775  C CG  A LYS A 1 70  ? 6.46012   -35.08489 -6.28701  0.708 13.35285 ? 151  LYS A CG  1 
ATOM   776  C CG  B LYS A 1 70  ? 6.66189   -35.66723 -5.45949  0.292 18.48480 ? 151  LYS A CG  1 
ATOM   777  C CD  A LYS A 1 70  ? 6.33406   -35.28091 -4.78582  0.708 15.55056 ? 151  LYS A CD  1 
ATOM   778  C CD  B LYS A 1 70  ? 7.72236   -34.60019 -5.22659  0.292 17.20839 ? 151  LYS A CD  1 
ATOM   779  C CE  A LYS A 1 70  ? 7.66310   -35.06100 -4.08165  0.708 16.14525 ? 151  LYS A CE  1 
ATOM   780  C CE  B LYS A 1 70  ? 8.32761   -34.69918 -3.83213  0.292 19.21216 ? 151  LYS A CE  1 
ATOM   781  N NZ  A LYS A 1 70  ? 8.05361   -33.62564 -4.04903  0.708 16.97008 ? 151  LYS A NZ  1 
ATOM   782  N NZ  B LYS A 1 70  ? 7.31326   -35.02482 -2.79267  0.292 20.16882 ? 151  LYS A NZ  1 
ATOM   783  N N   A SER A 1 71  ? 2.96772   -34.61401 -9.40815  0.708 11.08540 ? 152  SER A N   1 
ATOM   784  N N   B SER A 1 71  ? 3.50048   -34.99693 -8.80457  0.292 10.89046 ? 152  SER A N   1 
ATOM   785  C CA  A SER A 1 71  ? 1.65419   -34.89765 -9.97925  0.708 11.65389 ? 152  SER A CA  1 
ATOM   786  C CA  B SER A 1 71  ? 2.22423   -35.47656 -9.32692  0.292 13.17683 ? 152  SER A CA  1 
ATOM   787  C C   A SER A 1 71  ? 1.68875   -35.12320 -11.48597 0.708 11.98217 ? 152  SER A C   1 
ATOM   788  C C   B SER A 1 71  ? 2.28310   -35.82769 -10.81076 0.292 11.57190 ? 152  SER A C   1 
ATOM   789  O O   A SER A 1 71  ? 0.69626   -35.60404 -12.05056 0.708 14.39153 ? 152  SER A O   1 
ATOM   790  O O   B SER A 1 71  ? 1.56955   -36.73585 -11.25293 0.292 13.38085 ? 152  SER A O   1 
ATOM   791  C CB  A SER A 1 71  ? 0.72430   -33.71532 -9.71290  0.708 12.19740 ? 152  SER A CB  1 
ATOM   792  C CB  B SER A 1 71  ? 1.12636   -34.44658 -9.05773  0.292 15.30600 ? 152  SER A CB  1 
ATOM   793  O OG  A SER A 1 71  ? 0.43120   -33.58218 -8.33805  0.708 12.35513 ? 152  SER A OG  1 
ATOM   794  O OG  B SER A 1 71  ? 1.02800   -33.49984 -10.10504 0.292 17.11745 ? 152  SER A OG  1 
ATOM   795  N N   A THR A 1 72  ? 2.78591   -34.75338 -12.15005 0.708 10.35043 ? 153  THR A N   1 
ATOM   796  N N   B THR A 1 72  ? 3.10821   -35.13164 -11.59109 0.292 9.76964  ? 153  THR A N   1 
ATOM   797  C CA  A THR A 1 72  ? 2.92801   -34.90832 -13.58670 0.708 10.44341 ? 153  THR A CA  1 
ATOM   798  C CA  B THR A 1 72  ? 3.25196   -35.40338 -13.01578 0.292 9.37492  ? 153  THR A CA  1 
ATOM   799  C C   A THR A 1 72  ? 4.12803   -35.76125 -13.98660 0.708 11.12024 ? 153  THR A C   1 
ATOM   800  C C   B THR A 1 72  ? 4.46246   -36.26869 -13.33281 0.292 8.62608  ? 153  THR A C   1 
ATOM   801  O O   A THR A 1 72  ? 4.34767   -35.95540 -15.18908 0.708 13.53273 ? 153  THR A O   1 
ATOM   802  O O   B THR A 1 72  ? 4.65969   -36.63625 -14.49561 0.292 13.80252 ? 153  THR A O   1 
ATOM   803  C CB  A THR A 1 72  ? 2.98693   -33.53096 -14.28417 0.708 12.21536 ? 153  THR A CB  1 
ATOM   804  C CB  B THR A 1 72  ? 3.32742   -34.09225 -13.80353 0.292 11.38262 ? 153  THR A CB  1 
ATOM   805  O OG1 A THR A 1 72  ? 4.09329   -32.76536 -13.78854 0.708 11.75364 ? 153  THR A OG1 1 
ATOM   806  O OG1 B THR A 1 72  ? 4.45750   -33.33526 -13.35859 0.292 9.76188  ? 153  THR A OG1 1 
ATOM   807  C CG2 A THR A 1 72  ? 1.70654   -32.74541 -14.04127 0.708 14.41396 ? 153  THR A CG2 1 
ATOM   808  C CG2 B THR A 1 72  ? 2.06290   -33.27817 -13.59564 0.292 15.05197 ? 153  THR A CG2 1 
ATOM   809  N N   A GLY A 1 73  ? 4.90623   -36.26993 -13.02757 0.708 12.78033 ? 154  GLY A N   1 
ATOM   810  N N   B GLY A 1 73  ? 5.26121   -36.61541 -12.32464 0.292 12.00372 ? 154  GLY A N   1 
ATOM   811  C CA  A GLY A 1 73  ? 6.11178   -37.01704 -13.33956 0.708 12.29263 ? 154  GLY A CA  1 
ATOM   812  C CA  B GLY A 1 73  ? 6.46551   -37.39516 -12.52879 0.292 12.80999 ? 154  GLY A CA  1 
ATOM   813  C C   A GLY A 1 73  ? 7.23144   -36.20228 -13.94598 0.708 9.65316  ? 154  GLY A C   1 
ATOM   814  C C   B GLY A 1 73  ? 7.60119   -36.64279 -13.17808 0.292 12.83689 ? 154  GLY A C   1 
ATOM   815  O O   A GLY A 1 73  ? 8.08370   -36.76013 -14.64745 0.708 11.82682 ? 154  GLY A O   1 
ATOM   816  O O   B GLY A 1 73  ? 8.49604   -37.26700 -13.75541 0.292 14.76714 ? 154  GLY A O   1 
ATOM   817  N N   A THR A 1 74  ? 7.24581   -34.89301 -13.71295 0.708 10.88860 ? 155  THR A N   1 
ATOM   818  N N   B THR A 1 74  ? 7.60301   -35.31858 -13.08808 0.292 9.26834  ? 155  THR A N   1 
ATOM   819  C CA  A THR A 1 74  ? 8.25206   -33.99692 -14.26158 0.708 9.75724  ? 155  THR A CA  1 
ATOM   820  C CA  B THR A 1 74  ? 8.51892   -34.48116 -13.84064 0.292 9.63486  ? 155  THR A CA  1 
ATOM   821  C C   A THR A 1 74  ? 9.17378   -33.48648 -13.15467 0.708 10.79874 ? 155  THR A C   1 
ATOM   822  C C   B THR A 1 74  ? 9.49262   -33.78022 -12.90602 0.292 8.52884  ? 155  THR A C   1 
ATOM   823  O O   A THR A 1 74  ? 8.83712   -33.50745 -11.96485 0.708 10.21261 ? 155  THR A O   1 
ATOM   824  O O   B THR A 1 74  ? 9.41554   -33.87079 -11.67621 0.292 11.81488 ? 155  THR A O   1 
ATOM   825  C CB  A THR A 1 74  ? 7.59822   -32.79888 -14.96431 0.708 11.56427 ? 155  THR A CB  1 
ATOM   826  C CB  B THR A 1 74  ? 7.74693   -33.41723 -14.61962 0.292 9.34937  ? 155  THR A CB  1 
ATOM   827  O OG1 A THR A 1 74  ? 6.75376   -32.09998 -14.04345 0.708 10.76453 ? 155  THR A OG1 1 
ATOM   828  O OG1 B THR A 1 74  ? 6.81914   -32.76990 -13.74184 0.292 12.67334 ? 155  THR A OG1 1 
ATOM   829  C CG2 A THR A 1 74  ? 6.77753   -33.24987 -16.16291 0.708 12.11120 ? 155  THR A CG2 1 
ATOM   830  C CG2 B THR A 1 74  ? 6.98565   -34.03861 -15.76856 0.292 11.67538 ? 155  THR A CG2 1 
ATOM   831  N N   A LYS A 1 75  ? 10.36192  -33.04232 -13.55876 0.708 10.28907 ? 156  LYS A N   1 
ATOM   832  N N   B LYS A 1 75  ? 10.40478  -33.04989 -13.52898 0.292 10.32180 ? 156  LYS A N   1 
ATOM   833  C CA  A LYS A 1 75  ? 11.27455  -32.30813 -12.68881 0.708 10.43223 ? 156  LYS A CA  1 
ATOM   834  C CA  B LYS A 1 75  ? 11.31637  -32.14340 -12.85898 0.292 10.97716 ? 156  LYS A CA  1 
ATOM   835  C C   A LYS A 1 75  ? 11.10931  -30.82804 -12.99376 0.708 8.16180  ? 156  LYS A C   1 
ATOM   836  C C   B LYS A 1 75  ? 10.85296  -30.72959 -13.18589 0.292 10.29666 ? 156  LYS A C   1 
ATOM   837  O O   A LYS A 1 75  ? 11.17291  -30.42537 -14.16082 0.708 10.11452 ? 156  LYS A O   1 
ATOM   838  O O   B LYS A 1 75  ? 10.65273  -30.40088 -14.35955 0.292 8.59761  ? 156  LYS A O   1 
ATOM   839  C CB  A LYS A 1 75  ? 12.72528  -32.71861 -12.94384 0.708 10.29008 ? 156  LYS A CB  1 
ATOM   840  C CB  B LYS A 1 75  ? 12.72800  -32.37363 -13.40210 0.292 11.92796 ? 156  LYS A CB  1 
ATOM   841  C CG  A LYS A 1 75  ? 13.02395  -34.16235 -12.63029 0.708 12.08543 ? 156  LYS A CG  1 
ATOM   842  C CG  B LYS A 1 75  ? 12.98690  -33.80955 -13.84270 0.292 17.30874 ? 156  LYS A CG  1 
ATOM   843  C CD  A LYS A 1 75  ? 14.51939  -34.41666 -12.62312 0.708 18.13062 ? 156  LYS A CD  1 
ATOM   844  C CD  B LYS A 1 75  ? 14.38323  -34.27351 -13.47627 0.292 16.97420 ? 156  LYS A CD  1 
ATOM   845  C CE  A LYS A 1 75  ? 14.82862  -35.80561 -12.10199 0.708 19.93267 ? 156  LYS A CE  1 
ATOM   846  C CE  B LYS A 1 75  ? 14.49658  -34.51597 -11.98324 0.292 18.80223 ? 156  LYS A CE  1 
ATOM   847  N NZ  A LYS A 1 75  ? 16.25073  -36.18431 -12.31776 0.708 22.37477 ? 156  LYS A NZ  1 
ATOM   848  N NZ  B LYS A 1 75  ? 15.05467  -33.33790 -11.26760 0.292 19.43813 ? 156  LYS A NZ  1 
ATOM   849  N N   A GLN A 1 76  ? 10.88197  -30.02337 -11.96001 0.708 7.86691  ? 157  GLN A N   1 
ATOM   850  N N   B GLN A 1 76  ? 10.64511  -29.91287 -12.15380 0.292 7.84983  ? 157  GLN A N   1 
ATOM   851  C CA  A GLN A 1 76  ? 10.45374  -28.64349 -12.14553 0.708 7.81082  ? 157  GLN A CA  1 
ATOM   852  C CA  B GLN A 1 76  ? 10.23673  -28.52104 -12.30877 0.292 7.78162  ? 157  GLN A CA  1 
ATOM   853  C C   A GLN A 1 76  ? 11.58885  -27.66077 -11.89846 0.708 7.15842  ? 157  GLN A C   1 
ATOM   854  C C   B GLN A 1 76  ? 11.40317  -27.57514 -12.06398 0.292 7.87583  ? 157  GLN A C   1 
ATOM   855  O O   A GLN A 1 76  ? 12.51376  -27.92810 -11.12768 0.708 8.49533  ? 157  GLN A O   1 
ATOM   856  O O   B GLN A 1 76  ? 12.32173  -27.88118 -11.30056 0.292 8.05801  ? 157  GLN A O   1 
ATOM   857  C CB  A GLN A 1 76  ? 9.27265   -28.32847 -11.22928 0.708 8.63328  ? 157  GLN A CB  1 
ATOM   858  C CB  B GLN A 1 76  ? 9.10794   -28.16557 -11.34518 0.292 8.78776  ? 157  GLN A CB  1 
ATOM   859  C CG  A GLN A 1 76  ? 8.04900   -29.19829 -11.50042 0.708 9.76908  ? 157  GLN A CG  1 
ATOM   860  C CG  B GLN A 1 76  ? 7.93001   -29.08297 -11.43348 0.292 10.26203 ? 157  GLN A CG  1 
ATOM   861  C CD  A GLN A 1 76  ? 6.97126   -28.51185 -12.32895 0.708 10.63264 ? 157  GLN A CD  1 
ATOM   862  C CD  B GLN A 1 76  ? 7.13811   -28.82683 -12.68167 0.292 11.32821 ? 157  GLN A CD  1 
ATOM   863  O OE1 A GLN A 1 76  ? 6.70789   -27.31902 -12.17910 0.708 12.62469 ? 157  GLN A OE1 1 
ATOM   864  O OE1 B GLN A 1 76  ? 6.83849   -27.67753 -13.01295 0.292 12.67753 ? 157  GLN A OE1 1 
ATOM   865  N NE2 A GLN A 1 76  ? 6.30977   -29.28453 -13.18280 0.708 12.38632 ? 157  GLN A NE2 1 
ATOM   866  N NE2 B GLN A 1 76  ? 6.77988   -29.89237 -13.38234 0.292 9.92252  ? 157  GLN A NE2 1 
ATOM   867  N N   A LEU A 1 77  ? 11.47964  -26.50233 -12.55282 0.708 7.40165  ? 158  LEU A N   1 
ATOM   868  N N   B LEU A 1 77  ? 11.33149  -26.40138 -12.69296 0.292 7.75606  ? 158  LEU A N   1 
ATOM   869  C CA  A LEU A 1 77  ? 12.48558  -25.45339 -12.53158 0.708 7.43391  ? 158  LEU A CA  1 
ATOM   870  C CA  B LEU A 1 77  ? 12.39247  -25.40682 -12.64607 0.292 7.50640  ? 158  LEU A CA  1 
ATOM   871  C C   A LEU A 1 77  ? 11.79798  -24.11075 -12.30186 0.708 7.13296  ? 158  LEU A C   1 
ATOM   872  C C   B LEU A 1 77  ? 11.77516  -24.05096 -12.33613 0.292 7.15217  ? 158  LEU A C   1 
ATOM   873  O O   A LEU A 1 77  ? 10.85296  -23.75512 -13.01598 0.708 8.05557  ? 158  LEU A O   1 
ATOM   874  O O   B LEU A 1 77  ? 10.85549  -23.61400 -13.03719 0.292 7.88004  ? 158  LEU A O   1 
ATOM   875  C CB  A LEU A 1 77  ? 13.26286  -25.46148 -13.85471 0.708 6.98929  ? 158  LEU A CB  1 
ATOM   876  C CB  B LEU A 1 77  ? 13.08906  -25.33790 -14.00649 0.292 8.81260  ? 158  LEU A CB  1 
ATOM   877  C CG  A LEU A 1 77  ? 14.45829  -24.51609 -14.04058 0.708 6.21125  ? 158  LEU A CG  1 
ATOM   878  C CG  B LEU A 1 77  ? 14.60535  -25.16346 -14.01934 0.292 14.14992 ? 158  LEU A CG  1 
ATOM   879  C CD1 A LEU A 1 77  ? 15.38538  -25.07421 -15.10479 0.708 7.56633  ? 158  LEU A CD1 1 
ATOM   880  C CD1 B LEU A 1 77  ? 15.12446  -25.12310 -15.45300 0.292 7.13937  ? 158  LEU A CD1 1 
ATOM   881  C CD2 A LEU A 1 77  ? 14.03875  -23.08338 -14.36678 0.708 6.20002  ? 158  LEU A CD2 1 
ATOM   882  C CD2 B LEU A 1 77  ? 15.02696  -23.94274 -13.23721 0.292 14.46201 ? 158  LEU A CD2 1 
ATOM   883  N N   . VAL A 1 78  ? 12.28380  -23.37709 -11.30348 1.000 7.26925  ? 159  VAL A N   1 
ATOM   884  C CA  . VAL A 1 78  ? 11.79229  -22.05683 -10.91726 1.000 7.19653  ? 159  VAL A CA  1 
ATOM   885  C C   . VAL A 1 78  ? 12.82920  -21.00359 -11.30718 1.000 6.46744  ? 159  VAL A C   1 
ATOM   886  O O   . VAL A 1 78  ? 14.02475  -21.15381 -11.02612 1.000 7.15192  ? 159  VAL A O   1 
ATOM   887  C CB  . VAL A 1 78  ? 11.45703  -22.00804 -9.41651  1.000 7.70126  ? 159  VAL A CB  1 
ATOM   888  C CG1 . VAL A 1 78  ? 11.15230  -20.58893 -8.95524  1.000 9.36040  ? 159  VAL A CG1 1 
ATOM   889  C CG2 . VAL A 1 78  ? 10.30321  -22.95723 -9.11007  1.000 8.43849  ? 159  VAL A CG2 1 
ATOM   890  N N   . GLN A 1 79  ? 12.35691  -19.94772 -11.97030 1.000 6.83726  ? 160  GLN A N   1 
ATOM   891  C CA  . GLN A 1 79  ? 13.18700  -18.88464 -12.53989 1.000 6.63117  ? 160  GLN A CA  1 
ATOM   892  C C   . GLN A 1 79  ? 13.04759  -17.61210 -11.71359 1.000 6.72652  ? 160  GLN A C   1 
ATOM   893  O O   . GLN A 1 79  ? 11.93941  -17.07922 -11.58690 1.000 7.18762  ? 160  GLN A O   1 
ATOM   894  C CB  . GLN A 1 79  ? 12.73260  -18.58246 -13.96952 1.000 7.12327  ? 160  GLN A CB  1 
ATOM   895  C CG  . GLN A 1 79  ? 12.82916  -19.78976 -14.89686 1.000 7.51237  ? 160  GLN A CG  1 
ATOM   896  C CD  . GLN A 1 79  ? 12.54180  -19.48662 -16.34929 1.000 6.76811  ? 160  GLN A CD  1 
ATOM   897  O OE1 . GLN A 1 79  ? 13.19348  -20.04071 -17.23504 1.000 8.44833  ? 160  GLN A OE1 1 
ATOM   898  N NE2 . GLN A 1 79  ? 11.55858  -18.62867 -16.61067 1.000 7.58491  ? 160  GLN A NE2 1 
ATOM   899  N N   . ILE A 1 80  ? 14.16666  -17.10753 -11.18116 1.000 6.72737  ? 161  ILE A N   1 
ATOM   900  C CA  . ILE A 1 80  ? 14.15377  -15.95343 -10.28850 1.000 6.78655  ? 161  ILE A CA  1 
ATOM   901  C C   . ILE A 1 80  ? 15.19331  -14.92257 -10.70558 1.000 6.33661  ? 161  ILE A C   1 
ATOM   902  O O   . ILE A 1 80  ? 16.19723  -15.23587 -11.34960 1.000 6.70275  ? 161  ILE A O   1 
ATOM   903  C CB  . ILE A 1 80  ? 14.34261  -16.33698 -8.80249  1.000 7.50648  ? 161  ILE A CB  1 
ATOM   904  C CG1 . ILE A 1 80  ? 15.74361  -16.91889 -8.54837  1.000 8.01606  ? 161  ILE A CG1 1 
ATOM   905  C CG2 . ILE A 1 80  ? 13.25741  -17.29438 -8.36668  1.000 9.68839  ? 161  ILE A CG2 1 
ATOM   906  C CD1 . ILE A 1 80  ? 16.03892  -17.24161 -7.08064  1.000 8.88140  ? 161  ILE A CD1 1 
ATOM   907  N N   . VAL A 1 81  ? 14.93642  -13.67676 -10.31006 1.000 7.05426  ? 162  VAL A N   1 
ATOM   908  C CA  . VAL A 1 81  ? 15.88841  -12.58030 -10.42197 1.000 6.72529  ? 162  VAL A CA  1 
ATOM   909  C C   . VAL A 1 81  ? 16.21902  -12.09662 -9.01737  1.000 6.53439  ? 162  VAL A C   1 
ATOM   910  O O   . VAL A 1 81  ? 15.31998  -11.77093 -8.23083  1.000 7.15371  ? 162  VAL A O   1 
ATOM   911  C CB  . VAL A 1 81  ? 15.35035  -11.41159 -11.27372 1.000 7.11941  ? 162  VAL A CB  1 
ATOM   912  C CG1 . VAL A 1 81  ? 16.45365  -10.39409 -11.52683 1.000 7.50617  ? 162  VAL A CG1 1 
ATOM   913  C CG2 . VAL A 1 81  ? 14.73594  -11.89612 -12.57095 1.000 8.35997  ? 162  VAL A CG2 1 
ATOM   914  N N   . ILE A 1 82  ? 17.50901  -12.05733 -8.71748  1.000 6.99028  ? 163  ILE A N   1 
ATOM   915  C CA  . ILE A 1 82  ? 18.04121  -11.48276 -7.48774  1.000 7.16288  ? 163  ILE A CA  1 
ATOM   916  C C   . ILE A 1 82  ? 18.25040  -9.99547  -7.77055  1.000 6.85300  ? 163  ILE A C   1 
ATOM   917  O O   . ILE A 1 82  ? 19.05942  -9.63816  -8.62528  1.000 7.23781  ? 163  ILE A O   1 
ATOM   918  C CB  . ILE A 1 82  ? 19.35527  -12.18082 -7.10582  1.000 7.18683  ? 163  ILE A CB  1 
ATOM   919  C CG1 . ILE A 1 82  ? 19.18339  -13.70684 -7.01735  1.000 8.23258  ? 163  ILE A CG1 1 
ATOM   920  C CG2 . ILE A 1 82  ? 19.93326  -11.61819 -5.82876  1.000 8.62405  ? 163  ILE A CG2 1 
ATOM   921  C CD1 . ILE A 1 82  ? 18.20555  -14.17165 -5.96563  1.000 10.76646 ? 163  ILE A CD1 1 
ATOM   922  N N   . TYR A 1 83  ? 17.49806  -9.12155  -7.08528  1.000 7.19987  ? 164  TYR A N   1 
ATOM   923  C CA  . TYR A 1 83  ? 17.45372  -7.70236  -7.46970  1.000 7.49079  ? 164  TYR A CA  1 
ATOM   924  C C   . TYR A 1 83  ? 17.16212  -6.84512  -6.24179  1.000 7.52445  ? 164  TYR A C   1 
ATOM   925  O O   . TYR A 1 83  ? 16.10862  -6.21950  -6.13137  1.000 8.36705  ? 164  TYR A O   1 
ATOM   926  C CB  . TYR A 1 83  ? 16.41618  -7.46346  -8.56656  1.000 7.78504  ? 164  TYR A CB  1 
ATOM   927  C CG  . TYR A 1 83  ? 16.42231  -6.06951  -9.18312  1.000 7.86320  ? 164  TYR A CG  1 
ATOM   928  C CD1 . TYR A 1 83  ? 17.59321  -5.49791  -9.68411  1.000 8.69904  ? 164  TYR A CD1 1 
ATOM   929  C CD2 . TYR A 1 83  ? 15.24768  -5.34406  -9.29791  1.000 9.12451  ? 164  TYR A CD2 1 
ATOM   930  C CE1 . TYR A 1 83  ? 17.58757  -4.23342  -10.28224 1.000 9.97328  ? 164  TYR A CE1 1 
ATOM   931  C CE2 . TYR A 1 83  ? 15.22774  -4.09431  -9.90414  1.000 11.70483 ? 164  TYR A CE2 1 
ATOM   932  C CZ  . TYR A 1 83  ? 16.39461  -3.54596  -10.39611 1.000 10.17001 ? 164  TYR A CZ  1 
ATOM   933  O OH  . TYR A 1 83  ? 16.34189  -2.29936  -10.98574 1.000 12.57422 ? 164  TYR A OH  1 
ATOM   934  N N   . ASP A 1 84  ? 18.12856  -6.76232  -5.31944  1.000 7.42423  ? 165  ASP A N   1 
ATOM   935  C CA  . ASP A 1 84  ? 17.90968  -5.96126  -4.11871  1.000 7.67674  ? 165  ASP A CA  1 
ATOM   936  C C   . ASP A 1 84  ? 19.19522  -5.34873  -3.57580  1.000 7.33955  ? 165  ASP A C   1 
ATOM   937  O O   . ASP A 1 84  ? 19.30275  -5.13312  -2.36605  1.000 7.86835  ? 165  ASP A O   1 
ATOM   938  C CB  . ASP A 1 84  ? 17.16076  -6.77128  -3.04904  1.000 7.95758  ? 165  ASP A CB  1 
ATOM   939  C CG  . ASP A 1 84  ? 16.37094  -5.91851  -2.07447  1.000 7.91517  ? 165  ASP A CG  1 
ATOM   940  O OD1 . ASP A 1 84  ? 16.21373  -4.69132  -2.24795  1.000 9.13636  ? 165  ASP A OD1 1 
ATOM   941  O OD2 . ASP A 1 84  ? 15.89211  -6.54682  -1.10082  1.000 9.06495  ? 165  ASP A OD2 1 
ATOM   942  N N   . LEU A 1 85  ? 20.14669  -5.00565  -4.44123  1.000 8.00269  ? 166  LEU A N   1 
ATOM   943  C CA  . LEU A 1 85  ? 21.39945  -4.44243  -3.94975  1.000 8.04650  ? 166  LEU A CA  1 
ATOM   944  C C   . LEU A 1 85  ? 21.15268  -3.16003  -3.16000  1.000 8.08605  ? 166  LEU A C   1 
ATOM   945  O O   . LEU A 1 85  ? 20.24628  -2.38586  -3.47789  1.000 9.04054  ? 166  LEU A O   1 
ATOM   946  C CB  . LEU A 1 85  ? 22.34136  -4.12199  -5.10640  1.000 8.32487  ? 166  LEU A CB  1 
ATOM   947  C CG  . LEU A 1 85  ? 23.07699  -5.32133  -5.67066  1.000 8.02062  ? 166  LEU A CG  1 
ATOM   948  C CD1 . LEU A 1 85  ? 23.81989  -4.91521  -6.91415  1.000 9.43094  ? 166  LEU A CD1 1 
ATOM   949  C CD2 . LEU A 1 85  ? 24.03057  -5.89774  -4.68032  1.000 8.88037  ? 166  LEU A CD2 1 
ATOM   950  N N   . PRO A 1 86  ? 21.98288  -2.88886  -2.15804  1.000 8.78506  ? 167  PRO A N   1 
ATOM   951  C CA  . PRO A 1 86  ? 21.96651  -1.55721  -1.55302  1.000 9.37936  ? 167  PRO A CA  1 
ATOM   952  C C   . PRO A 1 86  ? 22.37035  -0.51690  -2.58626  1.000 8.91296  ? 167  PRO A C   1 
ATOM   953  O O   . PRO A 1 86  ? 23.23195  -0.75466  -3.43282  1.000 9.74290  ? 167  PRO A O   1 
ATOM   954  C CB  . PRO A 1 86  ? 22.99675  -1.66440  -0.41942  1.000 11.36884 ? 167  PRO A CB  1 
ATOM   955  C CG  . PRO A 1 86  ? 23.26744  -3.13391  -0.25414  1.000 11.01936 ? 167  PRO A CG  1 
ATOM   956  C CD  . PRO A 1 86  ? 23.04789  -3.73387  -1.58950  1.000 8.94053  ? 167  PRO A CD  1 
ATOM   957  N N   . ASP A 1 87  ? 21.74310  0.65425   -2.50599  1.000 9.53377  ? 168  ASP A N   1 
ATOM   958  C CA  . ASP A 1 87  ? 21.97186  1.71269   -3.49125  1.000 9.79928  ? 168  ASP A CA  1 
ATOM   959  C C   . ASP A 1 87  ? 21.76772  1.17134   -4.90955  1.000 9.11779  ? 168  ASP A C   1 
ATOM   960  O O   . ASP A 1 87  ? 22.54865  1.44692   -5.82278  1.000 9.55020  ? 168  ASP A O   1 
ATOM   961  C CB  . ASP A 1 87  ? 23.35918  2.36195   -3.33239  1.000 10.17871 ? 168  ASP A CB  1 
ATOM   962  C CG  . ASP A 1 87  ? 23.43325  3.37481   -2.19914  1.000 10.65401 ? 168  ASP A CG  1 
ATOM   963  O OD1 . ASP A 1 87  ? 22.70907  3.23643   -1.19558  1.000 11.87512 ? 168  ASP A OD1 1 
ATOM   964  O OD2 . ASP A 1 87  ? 24.24800  4.31460   -2.32146  1.000 13.60045 ? 168  ASP A OD2 1 
ATOM   965  N N   . ARG A 1 88  ? 20.70473  0.38296   -5.06915  1.000 9.81993  ? 169  ARG A N   1 
ATOM   966  C CA  A ARG A 1 88  ? 20.35766  -0.24766  -6.33616  0.590 9.57135  ? 169  ARG A CA  1 
ATOM   967  C CA  B ARG A 1 88  ? 20.38820  -0.24164  -6.34780  0.410 9.55541  ? 169  ARG A CA  1 
ATOM   968  C C   . ARG A 1 88  ? 20.23178  0.79318   -7.44953  1.000 8.65425  ? 169  ARG A C   1 
ATOM   969  O O   . ARG A 1 88  ? 19.79915  1.92591   -7.21895  1.000 10.34611 ? 169  ARG A O   1 
ATOM   970  C CB  A ARG A 1 88  ? 19.01657  -0.96742  -6.14934  0.590 9.34442  ? 169  ARG A CB  1 
ATOM   971  C CB  B ARG A 1 88  ? 19.07506  -1.01724  -6.24859  0.410 9.95913  ? 169  ARG A CB  1 
ATOM   972  C CG  A ARG A 1 88  ? 18.75846  -2.10698  -7.12210  0.590 8.42879  ? 169  ARG A CG  1 
ATOM   973  C CG  B ARG A 1 88  ? 19.14749  -2.40575  -6.84101  0.410 11.63719 ? 169  ARG A CG  1 
ATOM   974  C CD  A ARG A 1 88  ? 17.48458  -2.90585  -6.74993  0.590 9.65168  ? 169  ARG A CD  1 
ATOM   975  C CD  B ARG A 1 88  ? 17.77518  -3.07155  -6.87850  0.410 9.72757  ? 169  ARG A CD  1 
ATOM   976  N NE  A ARG A 1 88  ? 16.24568  -2.12514  -6.80164  0.590 9.73201  ? 169  ARG A NE  1 
ATOM   977  N NE  B ARG A 1 88  ? 16.68647  -2.20423  -7.32772  0.410 8.45259  ? 169  ARG A NE  1 
ATOM   978  C CZ  A ARG A 1 88  ? 15.08537  -2.52682  -6.29797  0.590 9.47552  ? 169  ARG A CZ  1 
ATOM   979  C CZ  B ARG A 1 88  ? 15.40734  -2.41306  -7.03736  0.410 8.11766  ? 169  ARG A CZ  1 
ATOM   980  N NH1 A ARG A 1 88  ? 14.95671  -3.71092  -5.72692  0.590 8.73896  ? 169  ARG A NH1 1 
ATOM   981  N NH1 B ARG A 1 88  ? 15.03003  -3.42324  -6.27053  0.410 9.48216  ? 169  ARG A NH1 1 
ATOM   982  N NH2 A ARG A 1 88  ? 14.02957  -1.71932  -6.36960  0.590 12.01644 ? 169  ARG A NH2 1 
ATOM   983  N NH2 B ARG A 1 88  ? 14.48482  -1.58972  -7.52547  0.410 11.66767 ? 169  ARG A NH2 1 
ATOM   984  N N   A ASP A 1 89  ? 20.60800  0.38626   -8.66614  0.822 9.00281  ? 170  ASP A N   1 
ATOM   985  N N   B ASP A 1 89  ? 20.55130  0.38832   -8.67849  0.178 9.11577  ? 170  ASP A N   1 
ATOM   986  C CA  A ASP A 1 89  ? 20.41964  1.19095   -9.87656  0.822 9.31908  ? 170  ASP A CA  1 
ATOM   987  C CA  B ASP A 1 89  ? 20.35196  1.25299   -9.83914  0.178 9.39989  ? 170  ASP A CA  1 
ATOM   988  C C   A ASP A 1 89  ? 21.12712  2.53845   -9.77122  0.822 9.30605  ? 170  ASP A C   1 
ATOM   989  C C   B ASP A 1 89  ? 21.10432  2.57285   -9.66218  0.178 9.44769  ? 170  ASP A C   1 
ATOM   990  O O   A ASP A 1 89  ? 20.53792  3.60472   -9.95338  0.822 10.29082 ? 170  ASP A O   1 
ATOM   991  O O   B ASP A 1 89  ? 20.51534  3.65738   -9.64745  0.178 9.15459  ? 170  ASP A O   1 
ATOM   992  C CB  A ASP A 1 89  ? 18.94357  1.37750   -10.21769 0.822 11.18887 ? 170  ASP A CB  1 
ATOM   993  C CB  B ASP A 1 89  ? 18.85550  1.49949   -10.07300 0.178 11.18276 ? 170  ASP A CB  1 
ATOM   994  C CG  A ASP A 1 89  ? 18.19802  0.09527   -10.20425 0.822 11.53289 ? 170  ASP A CG  1 
ATOM   995  C CG  B ASP A 1 89  ? 18.42916  1.24254   -11.49926 0.178 12.28116 ? 170  ASP A CG  1 
ATOM   996  O OD1 A ASP A 1 89  ? 18.41145  -0.72646  -11.11067 0.822 11.29126 ? 170  ASP A OD1 1 
ATOM   997  O OD1 B ASP A 1 89  ? 19.30860  1.09332   -12.37026 0.178 12.39062 ? 170  ASP A OD1 1 
ATOM   998  O OD2 A ASP A 1 89  ? 17.41422  -0.11036  -9.26512  0.822 13.18380 ? 170  ASP A OD2 1 
ATOM   999  O OD2 B ASP A 1 89  ? 17.20638  1.19972   -11.74974 0.178 15.20449 ? 170  ASP A OD2 1 
ATOM   1000 N N   . CYS A 1 90  ? 22.42837  2.46617   -9.50910  1.000 9.15952  ? 171  CYS A N   1 
ATOM   1001 C CA  . CYS A 1 90  ? 23.19407  3.64748   -9.10933  1.000 9.34668  ? 171  CYS A CA  1 
ATOM   1002 C C   . CYS A 1 90  ? 23.20142  4.76929   -10.14375 1.000 9.65971  ? 171  CYS A C   1 
ATOM   1003 O O   . CYS A 1 90  ? 23.40146  5.93222   -9.77114  1.000 11.04680 ? 171  CYS A O   1 
ATOM   1004 C CB  . CYS A 1 90  ? 24.62656  3.27507   -8.74314  1.000 9.77157  ? 171  CYS A CB  1 
ATOM   1005 S SG  . CYS A 1 90  ? 25.56495  2.46270   -10.06223 1.000 9.57432  ? 171  CYS A SG  1 
ATOM   1006 N N   . ALA A 1 91  ? 23.03824  4.46121   -11.43059 1.000 10.13358 ? 172  ALA A N   1 
ATOM   1007 C CA  . ALA A 1 91  ? 23.08816  5.48740   -12.46602 1.000 10.78309 ? 172  ALA A CA  1 
ATOM   1008 C C   . ALA A 1 91  ? 21.71156  6.01400   -12.83899 1.000 10.92527 ? 172  ALA A C   1 
ATOM   1009 O O   . ALA A 1 91  ? 21.61578  6.93845   -13.65474 1.000 13.18533 ? 172  ALA A O   1 
ATOM   1010 C CB  . ALA A 1 91  ? 23.81740  4.96569   -13.70988 1.000 12.82499 ? 172  ALA A CB  1 
ATOM   1011 N N   . ALA A 1 92  ? 20.65152  5.46045   -12.26009 1.000 12.28035 ? 173  ALA A N   1 
ATOM   1012 C CA  . ALA A 1 92  ? 19.31063  5.92356   -12.56084 1.000 12.75320 ? 173  ALA A CA  1 
ATOM   1013 C C   . ALA A 1 92  ? 19.05736  7.25725   -11.87246 1.000 13.50064 ? 173  ALA A C   1 
ATOM   1014 O O   . ALA A 1 92  ? 19.68972  7.59845   -10.87131 1.000 16.65039 ? 173  ALA A O   1 
ATOM   1015 C CB  . ALA A 1 92  ? 18.28153  4.89712   -12.09161 1.000 15.07780 ? 173  ALA A CB  1 
ATOM   1016 N N   A LYS A 1 93  ? 18.11667  8.02242   -12.42622 0.591 13.80965 ? 174  LYS A N   1 
ATOM   1017 N N   B LYS A 1 93  ? 18.10857  8.01794   -12.41588 0.409 13.76159 ? 174  LYS A N   1 
ATOM   1018 C CA  A LYS A 1 93  ? 17.89176  9.39381   -11.98140 0.591 15.90376 ? 174  LYS A CA  1 
ATOM   1019 C CA  B LYS A 1 93  ? 17.67483  9.21798   -11.71378 0.409 17.23832 ? 174  LYS A CA  1 
ATOM   1020 C C   A LYS A 1 93  ? 17.10099  9.49463   -10.68306 0.591 20.87569 ? 174  LYS A C   1 
ATOM   1021 C C   B LYS A 1 93  ? 16.76735  8.88715   -10.53624 0.409 19.25862 ? 174  LYS A C   1 
ATOM   1022 O O   A LYS A 1 93  ? 16.91505  10.60807  -10.17709 0.591 23.64730 ? 174  LYS A O   1 
ATOM   1023 O O   B LYS A 1 93  ? 16.63439  9.70596   -9.62018  0.409 21.05201 ? 174  LYS A O   1 
ATOM   1024 C CB  A LYS A 1 93  ? 17.23988  10.22712  -13.08994 0.591 18.51260 ? 174  LYS A CB  1 
ATOM   1025 C CB  B LYS A 1 93  ? 17.03159  10.21039  -12.68424 0.409 17.69980 ? 174  LYS A CB  1 
ATOM   1026 C CG  A LYS A 1 93  ? 17.69057  9.83570   -14.49000 0.591 20.34759 ? 174  LYS A CG  1 
ATOM   1027 C CG  B LYS A 1 93  ? 17.85152  10.41436  -13.95212 0.409 19.05527 ? 174  LYS A CG  1 
ATOM   1028 C CD  A LYS A 1 93  ? 17.17221  10.80309  -15.53943 0.591 21.42300 ? 174  LYS A CD  1 
ATOM   1029 C CD  B LYS A 1 93  ? 17.15663  11.32923  -14.94263 0.409 19.00002 ? 174  LYS A CD  1 
ATOM   1030 C CE  A LYS A 1 93  ? 17.98463  10.70125  -16.82278 0.591 22.29424 ? 174  LYS A CE  1 
ATOM   1031 C CE  B LYS A 1 93  ? 17.61630  11.04481  -16.36430 0.409 22.91044 ? 174  LYS A CE  1 
ATOM   1032 N NZ  A LYS A 1 93  ? 17.15124  10.93066  -18.03593 0.591 23.81752 ? 174  LYS A NZ  1 
ATOM   1033 N NZ  B LYS A 1 93  ? 19.02657  10.56444  -16.41927 0.409 22.69738 ? 174  LYS A NZ  1 
ATOM   1034 N N   A ALA A 1 94  ? 16.63899  8.37559   -10.13251 0.591 18.25721 ? 175  ALA A N   1 
ATOM   1035 N N   B ALA A 1 94  ? 16.17126  7.69674   -10.52734 0.409 15.86209 ? 175  ALA A N   1 
ATOM   1036 C CA  A ALA A 1 94  ? 15.94340  8.36920   -8.85609  0.591 19.14008 ? 175  ALA A CA  1 
ATOM   1037 C CA  B ALA A 1 94  ? 15.33327  7.25435   -9.42441  0.409 19.17362 ? 175  ALA A CA  1 
ATOM   1038 C C   A ALA A 1 94  ? 16.31637  7.10289   -8.10444  0.591 20.06815 ? 175  ALA A C   1 
ATOM   1039 C C   B ALA A 1 94  ? 15.46542  5.74564   -9.28705  0.409 17.43760 ? 175  ALA A C   1 
ATOM   1040 O O   A ALA A 1 94  ? 16.52617  6.04983   -8.71364  0.591 18.69259 ? 175  ALA A O   1 
ATOM   1041 O O   B ALA A 1 94  ? 15.48672  5.02630   -10.28887 0.409 17.93711 ? 175  ALA A O   1 
ATOM   1042 C CB  A ALA A 1 94  ? 14.42297  8.42661   -9.04268  0.591 20.71445 ? 175  ALA A CB  1 
ATOM   1043 C CB  B ALA A 1 94  ? 13.86662  7.62210   -9.66520  0.409 18.41553 ? 175  ALA A CB  1 
ATOM   1044 N N   A SER A 1 95  ? 16.40507  7.21126   -6.78273  0.591 16.97150 ? 176  SER A N   1 
ATOM   1045 N N   B SER A 1 95  ? 15.55658  5.27254   -8.04606  0.409 18.10027 ? 176  SER A N   1 
ATOM   1046 C CA  A SER A 1 95  ? 16.72992  6.05197   -5.96827  0.591 14.09378 ? 176  SER A CA  1 
ATOM   1047 C CA  B SER A 1 95  ? 15.61926  3.84635   -7.76720  0.409 15.10286 ? 176  SER A CA  1 
ATOM   1048 C C   A SER A 1 95  ? 15.53353  5.11281   -5.87289  0.591 14.74586 ? 176  SER A C   1 
ATOM   1049 C C   B SER A 1 95  ? 14.62698  3.48445   -6.67283  0.409 16.28333 ? 176  SER A C   1 
ATOM   1050 O O   A SER A 1 95  ? 14.37442  5.53571   -5.89623  0.591 18.19808 ? 176  SER A O   1 
ATOM   1051 O O   B SER A 1 95  ? 14.31165  4.29659   -5.79929  0.409 20.17166 ? 176  SER A O   1 
ATOM   1052 C CB  A SER A 1 95  ? 17.15874  6.49309   -4.56936  0.591 14.35654 ? 176  SER A CB  1 
ATOM   1053 C CB  B SER A 1 95  ? 17.01832  3.39888   -7.34421  0.409 16.74511 ? 176  SER A CB  1 
ATOM   1054 O OG  A SER A 1 95  ? 16.05620  6.98632   -3.82869  0.591 21.78173 ? 176  SER A OG  1 
ATOM   1055 O OG  B SER A 1 95  ? 16.98987  2.06129   -6.87253  0.409 16.66694 ? 176  SER A OG  1 
ATOM   1056 N N   A ASN A 1 96  ? 15.82805  3.81932   -5.77888  0.591 12.52120 ? 177  ASN A N   1 
ATOM   1057 N N   B ASN A 1 96  ? 14.15064  2.24305   -6.72639  0.409 14.41761 ? 177  ASN A N   1 
ATOM   1058 C CA  A ASN A 1 96  ? 14.79844  2.81831   -5.55091  0.591 13.16460 ? 177  ASN A CA  1 
ATOM   1059 C CA  B ASN A 1 96  ? 13.16295  1.73172   -5.79027  0.409 16.63079 ? 177  ASN A CA  1 
ATOM   1060 C C   A ASN A 1 96  ? 15.43115  1.63759   -4.82765  0.591 12.29537 ? 177  ASN A C   1 
ATOM   1061 C C   B ASN A 1 96  ? 13.75140  0.76590   -4.76946  0.409 13.96068 ? 177  ASN A C   1 
ATOM   1062 O O   A ASN A 1 96  ? 16.65314  1.47012   -4.82431  0.591 12.60518 ? 177  ASN A O   1 
ATOM   1063 O O   B ASN A 1 96  ? 13.00531  0.24267   -3.93404  0.409 16.68705 ? 177  ASN A O   1 
ATOM   1064 C CB  A ASN A 1 96  ? 14.07669  2.42322   -6.85223  0.591 13.33416 ? 177  ASN A CB  1 
ATOM   1065 C CB  B ASN A 1 96  ? 12.02841  1.04915   -6.56353  0.409 17.61953 ? 177  ASN A CB  1 
ATOM   1066 C CG  A ASN A 1 96  ? 14.94022  1.58186   -7.78070  0.591 14.05165 ? 177  ASN A CG  1 
ATOM   1067 C CG  B ASN A 1 96  ? 11.10758  2.04428   -7.24319  0.409 19.52677 ? 177  ASN A CG  1 
ATOM   1068 O OD1 A ASN A 1 96  ? 15.20713  0.41456   -7.50867  0.591 15.15225 ? 177  ASN A OD1 1 
ATOM   1069 O OD1 B ASN A 1 96  ? 10.31409  2.71617   -6.59039  0.409 25.31286 ? 177  ASN A OD1 1 
ATOM   1070 N ND2 A ASN A 1 96  ? 15.37513  2.17550   -8.88912  0.591 14.85801 ? 177  ASN A ND2 1 
ATOM   1071 N ND2 B ASN A 1 96  ? 11.22614  2.15757   -8.56250  0.409 19.58832 ? 177  ASN A ND2 1 
ATOM   1072 N N   A GLY A 1 97  ? 14.59167  0.83778   -4.18244  0.591 11.98964 ? 178  GLY A N   1 
ATOM   1073 N N   B GLY A 1 97  ? 15.05988  0.52114   -4.80818  0.409 13.43819 ? 178  GLY A N   1 
ATOM   1074 C CA  A GLY A 1 97  ? 15.09308  -0.30581  -3.45122  0.591 12.07606 ? 178  GLY A CA  1 
ATOM   1075 C CA  B GLY A 1 97  ? 15.64998  -0.45063  -3.90021  0.409 11.79022 ? 178  GLY A CA  1 
ATOM   1076 C C   A GLY A 1 97  ? 15.18259  -0.06181  -1.96103  0.591 10.27458 ? 178  GLY A C   1 
ATOM   1077 C C   B GLY A 1 97  ? 15.53878  -0.00799  -2.45075  0.409 11.59836 ? 178  GLY A C   1 
ATOM   1078 O O   A GLY A 1 97  ? 15.52514  1.03796   -1.50939  0.591 11.33925 ? 178  GLY A O   1 
ATOM   1079 O O   B GLY A 1 97  ? 15.73382  1.16459   -2.12235  0.409 14.23341 ? 178  GLY A O   1 
ATOM   1080 N N   A GLU A 1 98  ? 14.89031  -1.10034  -1.18462  0.591 8.97519  ? 179  GLU A N   1 
ATOM   1081 N N   B GLU A 1 98  ? 15.23135  -0.96936  -1.56942  0.409 10.92898 ? 179  GLU A N   1 
ATOM   1082 C CA  A GLU A 1 98  ? 14.74287  -0.92891  0.25068   0.591 9.39691  ? 179  GLU A CA  1 
ATOM   1083 C CA  B GLU A 1 98  ? 14.88870  -0.62369  -0.18942  0.409 12.13504 ? 179  GLU A CA  1 
ATOM   1084 C C   A GLU A 1 98  ? 16.06392  -0.77650  0.99448   0.591 8.86932  ? 179  GLU A C   1 
ATOM   1085 C C   B GLU A 1 98  ? 16.10780  -0.45229  0.71120   0.409 11.28198 ? 179  GLU A C   1 
ATOM   1086 O O   A GLU A 1 98  ? 16.03279  -0.35050  2.15723   0.591 9.05620  ? 179  GLU A O   1 
ATOM   1087 O O   B GLU A 1 98  ? 16.03423  0.25125   1.72239   0.409 10.95948 ? 179  GLU A O   1 
ATOM   1088 C CB  A GLU A 1 98  ? 13.96244  -2.09802  0.83951   0.591 8.02404  ? 179  GLU A CB  1 
ATOM   1089 C CB  B GLU A 1 98  ? 13.93274  -1.64745  0.43501   0.409 10.84956 ? 179  GLU A CB  1 
ATOM   1090 C CG  A GLU A 1 98  ? 14.66996  -3.40765  0.66812   0.591 7.49462  ? 179  GLU A CG  1 
ATOM   1091 C CG  B GLU A 1 98  ? 14.56957  -2.92613  0.97652   0.409 17.64135 ? 179  GLU A CG  1 
ATOM   1092 C CD  A GLU A 1 98  ? 13.83715  -4.58179  1.11248   0.591 7.51961  ? 179  GLU A CD  1 
ATOM   1093 C CD  B GLU A 1 98  ? 13.69041  -4.14847  0.78138   0.409 11.84297 ? 179  GLU A CD  1 
ATOM   1094 O OE1 A GLU A 1 98  ? 12.94059  -4.40630  1.97090   0.591 9.15991  ? 179  GLU A OE1 1 
ATOM   1095 O OE1 B GLU A 1 98  ? 12.59088  -4.16020  1.37160   0.409 12.57153 ? 179  GLU A OE1 1 
ATOM   1096 O OE2 A GLU A 1 98  ? 14.09343  -5.67726  0.58854   0.591 6.48031  ? 179  GLU A OE2 1 
ATOM   1097 O OE2 B GLU A 1 98  ? 14.09730  -5.10806  0.09734   0.409 12.71191 ? 179  GLU A OE2 1 
ATOM   1098 N N   . PHE A 1 99  ? 17.21275  -1.09501  0.38174   1.000 9.96559  ? 180  PHE A N   1 
ATOM   1099 C CA  . PHE A 1 99  ? 18.45258  -1.04065  1.14338   1.000 9.90039  ? 180  PHE A CA  1 
ATOM   1100 C C   . PHE A 1 99  ? 19.36323  0.09052   0.67475   1.000 10.13103 ? 180  PHE A C   1 
ATOM   1101 O O   . PHE A 1 99  ? 19.43519  0.41878   -0.51388  1.000 10.71975 ? 180  PHE A O   1 
ATOM   1102 C CB  . PHE A 1 99  ? 19.20414  -2.36975  1.07023   1.000 10.05309 ? 180  PHE A CB  1 
ATOM   1103 C CG  . PHE A 1 99  ? 18.44253  -3.53534  1.64786   1.000 9.50386  ? 180  PHE A CG  1 
ATOM   1104 C CD1 . PHE A 1 99  ? 17.74232  -3.42051  2.84337   1.000 10.19457 ? 180  PHE A CD1 1 
ATOM   1105 C CD2 . PHE A 1 99  ? 18.42522  -4.74818  0.98452   1.000 9.96911  ? 180  PHE A CD2 1 
ATOM   1106 C CE1 . PHE A 1 99  ? 17.04623  -4.49564  3.36271   1.000 12.63210 ? 180  PHE A CE1 1 
ATOM   1107 C CE2 . PHE A 1 99  ? 17.74048  -5.82491  1.50120   1.000 11.48447 ? 180  PHE A CE2 1 
ATOM   1108 C CZ  . PHE A 1 99  ? 17.05039  -5.70023  2.68973   1.000 11.69472 ? 180  PHE A CZ  1 
ATOM   1109 N N   . SER A 1 100 ? 20.08592  0.66529   1.62813   1.000 10.60331 ? 181  SER A N   1 
ATOM   1110 C CA  . SER A 1 100 ? 21.03357  1.72695   1.34000   1.000 10.02183 ? 181  SER A CA  1 
ATOM   1111 C C   . SER A 1 100 ? 22.38270  1.40186   1.96621   1.000 9.76616  ? 181  SER A C   1 
ATOM   1112 O O   . SER A 1 100 ? 22.45251  0.85481   3.06752   1.000 10.44679 ? 181  SER A O   1 
ATOM   1113 C CB  . SER A 1 100 ? 20.52433  3.07324   1.85192   1.000 11.90711 ? 181  SER A CB  1 
ATOM   1114 O OG  . SER A 1 100 ? 20.30065  3.03274   3.24404   1.000 14.69419 ? 181  SER A OG  1 
ATOM   1115 N N   . ILE A 1 101 ? 23.45121  1.75884   1.25549   1.000 9.82695  ? 182  ILE A N   1 
ATOM   1116 C CA  . ILE A 1 101 ? 24.80092  1.50889   1.74774   1.000 10.99337 ? 182  ILE A CA  1 
ATOM   1117 C C   . ILE A 1 101 ? 25.00186  2.14577   3.11123   1.000 10.98519 ? 182  ILE A C   1 
ATOM   1118 O O   . ILE A 1 101 ? 25.60191  1.54347   4.01028   1.000 13.16339 ? 182  ILE A O   1 
ATOM   1119 C CB  . ILE A 1 101 ? 25.83549  2.00201   0.72310   1.000 10.77486 ? 182  ILE A CB  1 
ATOM   1120 C CG1 . ILE A 1 101 ? 25.75737  1.12750   -0.52632  1.000 11.05099 ? 182  ILE A CG1 1 
ATOM   1121 C CG2 . ILE A 1 101 ? 27.23320  1.97258   1.31489   1.000 12.78752 ? 182  ILE A CG2 1 
ATOM   1122 C CD1 . ILE A 1 101 ? 26.65249  1.56746   -1.64243  1.000 12.66798 ? 182  ILE A CD1 1 
ATOM   1123 N N   A ALA A 1 102 ? 24.39520  3.32029   3.32097   0.614 10.66696 ? 183  ALA A N   1 
ATOM   1124 N N   B ALA A 1 102 ? 24.57952  3.39864   3.26383   0.386 11.29118 ? 183  ALA A N   1 
ATOM   1125 C CA  A ALA A 1 102 ? 24.54888  4.12126   4.53135   0.614 13.07161 ? 183  ALA A CA  1 
ATOM   1126 C CA  B ALA A 1 102 ? 24.87706  4.12454   4.49018   0.386 12.97658 ? 183  ALA A CA  1 
ATOM   1127 C C   A ALA A 1 102 ? 23.77939  3.58012   5.73021   0.614 10.49412 ? 183  ALA A C   1 
ATOM   1128 C C   B ALA A 1 102 ? 24.19368  3.52587   5.70927   0.386 10.43588 ? 183  ALA A C   1 
ATOM   1129 O O   A ALA A 1 102 ? 24.01664  4.04533   6.85106   0.614 13.15097 ? 183  ALA A O   1 
ATOM   1130 O O   B ALA A 1 102 ? 24.53074  3.90327   6.83623   0.386 11.58815 ? 183  ALA A O   1 
ATOM   1131 C CB  A ALA A 1 102 ? 24.11114  5.56034   4.25859   0.614 13.19944 ? 183  ALA A CB  1 
ATOM   1132 C CB  B ALA A 1 102 ? 24.47938  5.59302   4.33989   0.386 14.90914 ? 183  ALA A CB  1 
ATOM   1133 N N   A ASN A 1 103 ? 22.85285  2.64702   5.52904   0.614 10.53019 ? 184  ASN A N   1 
ATOM   1134 N N   B ASN A 1 103 ? 23.26996  2.58777   5.51292   0.386 11.62106 ? 184  ASN A N   1 
ATOM   1135 C CA  A ASN A 1 103 ? 22.14649  2.01562   6.63547   0.614 10.70869 ? 184  ASN A CA  1 
ATOM   1136 C CA  B ASN A 1 103 ? 22.37731  2.10719   6.55859   0.386 11.71551 ? 184  ASN A CA  1 
ATOM   1137 C C   A ASN A 1 103 ? 22.41140  0.51312   6.60713   0.614 10.84694 ? 184  ASN A C   1 
ATOM   1138 C C   B ASN A 1 103 ? 22.38468  0.57599   6.53587   0.386 10.91585 ? 184  ASN A C   1 
ATOM   1139 O O   A ASN A 1 103 ? 21.49176  -0.27171  6.35977   0.614 10.10387 ? 184  ASN A O   1 
ATOM   1140 O O   B ASN A 1 103 ? 21.39831  -0.05391  6.14755   0.386 12.05423 ? 184  ASN A O   1 
ATOM   1141 C CB  A ASN A 1 103 ? 20.63943  2.28100   6.51285   0.614 11.08981 ? 184  ASN A CB  1 
ATOM   1142 C CB  B ASN A 1 103 ? 20.97576  2.64996   6.31359   0.386 14.75325 ? 184  ASN A CB  1 
ATOM   1143 C CG  A ASN A 1 103 ? 20.22104  3.64572   7.03797   0.614 13.99122 ? 184  ASN A CG  1 
ATOM   1144 C CG  B ASN A 1 103 ? 20.13520  2.66286   7.55294   0.386 17.87375 ? 184  ASN A CG  1 
ATOM   1145 O OD1 A ASN A 1 103 ? 21.02345  4.41731   7.57849   0.614 13.88763 ? 184  ASN A OD1 1 
ATOM   1146 O OD1 B ASN A 1 103 ? 19.70367  1.61881   8.03749   0.386 18.26491 ? 184  ASN A OD1 1 
ATOM   1147 N ND2 A ASN A 1 103 ? 18.94779  3.96536   6.83604   0.614 15.18458 ? 184  ASN A ND2 1 
ATOM   1148 N ND2 B ASN A 1 103 ? 19.86167  3.85943   8.05948   0.386 16.42723 ? 184  ASN A ND2 1 
ATOM   1149 N N   A ASN A 1 104 ? 23.66273  0.09886   6.81997   0.614 9.59550  ? 185  ASN A N   1 
ATOM   1150 N N   B ASN A 1 104 ? 23.50832  -0.01822  6.94267   0.386 11.31377 ? 185  ASN A N   1 
ATOM   1151 C CA  A ASN A 1 104 ? 23.98827  -1.32058  6.98266   0.614 9.32072  ? 185  ASN A CA  1 
ATOM   1152 C CA  B ASN A 1 104 ? 23.62699  -1.47226  7.06675   0.386 10.68438 ? 185  ASN A CA  1 
ATOM   1153 C C   A ASN A 1 104 ? 23.60743  -2.13178  5.74887   0.614 9.96440  ? 185  ASN A C   1 
ATOM   1154 C C   B ASN A 1 104 ? 23.26216  -2.18727  5.76762   0.386 8.85256  ? 185  ASN A C   1 
ATOM   1155 O O   A ASN A 1 104 ? 23.17206  -3.27928  5.84970   0.614 9.10137  ? 185  ASN A O   1 
ATOM   1156 O O   B ASN A 1 104 ? 22.81439  -3.33357  5.78732   0.386 11.63847 ? 185  ASN A O   1 
ATOM   1157 C CB  A ASN A 1 104 ? 23.33035  -1.90949  8.23360   0.614 9.53319  ? 185  ASN A CB  1 
ATOM   1158 C CB  B ASN A 1 104 ? 22.77618  -2.01658  8.22095   0.386 9.67106  ? 185  ASN A CB  1 
ATOM   1159 C CG  A ASN A 1 104 ? 23.41959  -0.98296  9.41898   0.614 9.52648  ? 185  ASN A CG  1 
ATOM   1160 C CG  B ASN A 1 104 ? 23.22319  -1.50908  9.58494   0.386 12.43316 ? 185  ASN A CG  1 
ATOM   1161 O OD1 A ASN A 1 104 ? 22.41142  -0.39379  9.85796   0.614 9.84115  ? 185  ASN A OD1 1 
ATOM   1162 O OD1 B ASN A 1 104 ? 24.39046  -1.18000  9.79783   0.386 13.55591 ? 185  ASN A OD1 1 
ATOM   1163 N ND2 A ASN A 1 104 ? 24.63532  -0.81948  9.93698   0.614 11.18228 ? 185  ASN A ND2 1 
ATOM   1164 N ND2 B ASN A 1 104 ? 22.28396  -1.45024  10.52084  0.386 18.41679 ? 185  ASN A ND2 1 
ATOM   1165 N N   A GLY A 1 105 ? 23.79901  -1.54421  4.56872   0.614 8.63284  ? 186  GLY A N   1 
ATOM   1166 N N   B GLY A 1 105 ? 23.44356  -1.51523  4.62935   0.386 10.65072 ? 186  GLY A N   1 
ATOM   1167 C CA  A GLY A 1 105 ? 23.34384  -2.20230  3.35405   0.614 9.60867  ? 186  GLY A CA  1 
ATOM   1168 C CA  B GLY A 1 105 ? 22.87233  -2.01461  3.38855   0.386 9.77515  ? 186  GLY A CA  1 
ATOM   1169 C C   A GLY A 1 105 ? 23.89072  -3.60906  3.19675   0.614 8.23385  ? 186  GLY A C   1 
ATOM   1170 C C   B GLY A 1 105 ? 23.43610  -3.35472  2.97725   0.386 8.62540  ? 186  GLY A C   1 
ATOM   1171 O O   A GLY A 1 105 ? 23.15391  -4.54012  2.86524   0.614 8.45986  ? 186  GLY A O   1 
ATOM   1172 O O   B GLY A 1 105 ? 22.68982  -4.27843  2.64375   0.386 8.95323  ? 186  GLY A O   1 
ATOM   1173 N N   A GLN A 1 106 ? 25.19525  -3.77986  3.42649   0.614 8.38064  ? 187  GLN A N   1 
ATOM   1174 N N   B GLN A 1 106 ? 24.76334  -3.47877  2.98304   0.386 9.02643  ? 187  GLN A N   1 
ATOM   1175 C CA  A GLN A 1 106 ? 25.82753  -5.07682  3.19982   0.614 8.16631  ? 187  GLN A CA  1 
ATOM   1176 C CA  B GLN A 1 106 ? 25.35453  -4.74913  2.58923   0.386 8.21654  ? 187  GLN A CA  1 
ATOM   1177 C C   A GLN A 1 106 ? 25.20915  -6.15729  4.08568   0.614 7.77321  ? 187  GLN A C   1 
ATOM   1178 C C   B GLN A 1 106 ? 24.97917  -5.85565  3.57079   0.386 8.18498  ? 187  GLN A C   1 
ATOM   1179 O O   A GLN A 1 106 ? 24.81511  -7.22292  3.59920   0.614 8.42064  ? 187  GLN A O   1 
ATOM   1180 O O   B GLN A 1 106 ? 24.63521  -6.96240  3.14920   0.386 8.29985  ? 187  GLN A O   1 
ATOM   1181 C CB  A GLN A 1 106 ? 27.34122  -4.96557  3.42283   0.614 9.05649  ? 187  GLN A CB  1 
ATOM   1182 C CB  B GLN A 1 106 ? 26.86612  -4.61679  2.39404   0.386 9.96937  ? 187  GLN A CB  1 
ATOM   1183 C CG  A GLN A 1 106 ? 28.12574  -6.23276  3.16911   0.614 8.63067  ? 187  GLN A CG  1 
ATOM   1184 C CG  B GLN A 1 106 ? 27.61058  -5.93890  2.37232   0.386 11.86791 ? 187  GLN A CG  1 
ATOM   1185 C CD  A GLN A 1 106 ? 28.09285  -6.67255  1.72136   0.614 9.09106  ? 187  GLN A CD  1 
ATOM   1186 C CD  B GLN A 1 106 ? 29.10947  -5.77557  2.19355   0.386 9.85720  ? 187  GLN A CD  1 
ATOM   1187 O OE1 A GLN A 1 106 ? 28.09840  -5.85046  0.80066   0.614 9.34645  ? 187  GLN A OE1 1 
ATOM   1188 O OE1 B GLN A 1 106 ? 29.58342  -4.74959  1.71019   0.386 13.13028 ? 187  GLN A OE1 1 
ATOM   1189 N NE2 A GLN A 1 106 ? 28.05224  -7.98260  1.51103   0.614 9.01899  ? 187  GLN A NE2 1 
ATOM   1190 N NE2 B GLN A 1 106 ? 29.86285  -6.80071  2.57426   0.386 12.97867 ? 187  GLN A NE2 1 
ATOM   1191 N N   A ALA A 1 107 ? 25.10490  -5.89957  5.39109   0.614 8.00880  ? 188  ALA A N   1 
ATOM   1192 N N   B ALA A 1 107 ? 24.98468  -5.56734  4.87836   0.386 8.79326  ? 188  ALA A N   1 
ATOM   1193 C CA  A ALA A 1 107 ? 24.47129  -6.87533  6.27056   0.614 9.44131  ? 188  ALA A CA  1 
ATOM   1194 C CA  B ALA A 1 107 ? 24.63030  -6.59623  5.85935   0.386 9.20087  ? 188  ALA A CA  1 
ATOM   1195 C C   A ALA A 1 107 ? 23.02330  -7.12244  5.86864   0.614 8.34785  ? 188  ALA A C   1 
ATOM   1196 C C   B ALA A 1 107 ? 23.17292  -7.03040  5.71518   0.386 9.27166  ? 188  ALA A C   1 
ATOM   1197 O O   A ALA A 1 107 ? 22.55563  -8.26955  5.89112   0.614 9.22580  ? 188  ALA A O   1 
ATOM   1198 O O   B ALA A 1 107 ? 22.84648  -8.21667  5.84070   0.386 9.69049  ? 188  ALA A O   1 
ATOM   1199 C CB  A ALA A 1 107 ? 24.56450  -6.42403  7.72816   0.614 9.91603  ? 188  ALA A CB  1 
ATOM   1200 C CB  B ALA A 1 107 ? 24.88917  -6.08210  7.27436   0.386 9.64385  ? 188  ALA A CB  1 
ATOM   1201 N N   . ASN A 1 108 ? 22.29060  -6.06357  5.48846   1.000 9.08011  ? 189  ASN A N   1 
ATOM   1202 C CA  . ASN A 1 108 ? 20.88509  -6.30134  5.17466   1.000 9.53129  ? 189  ASN A CA  1 
ATOM   1203 C C   . ASN A 1 108 ? 20.73503  -7.12731  3.90284   1.000 8.02063  ? 189  ASN A C   1 
ATOM   1204 O O   . ASN A 1 108 ? 19.86654  -8.00404  3.81986   1.000 8.76011  ? 189  ASN A O   1 
ATOM   1205 C CB  . ASN A 1 108 ? 20.14052  -4.97628  5.03315   1.000 9.92648  ? 189  ASN A CB  1 
ATOM   1206 C CG  . ASN A 1 108 ? 20.03995  -4.22968  6.33777   1.000 11.70856 ? 189  ASN A CG  1 
ATOM   1207 O OD1 . ASN A 1 108 ? 20.11595  -4.82561  7.40990   1.000 14.21939 ? 189  ASN A OD1 1 
ATOM   1208 N ND2 . ASN A 1 108 ? 19.82886  -2.92389  6.25783   1.000 14.42795 ? 189  ASN A ND2 1 
ATOM   1209 N N   . TYR A 1 109 ? 21.57520  -6.85922  2.90193   1.000 7.96944  ? 190  TYR A N   1 
ATOM   1210 C CA  . TYR A 1 109 ? 21.54409  -7.63614  1.67142   1.000 7.96914  ? 190  TYR A CA  1 
ATOM   1211 C C   . TYR A 1 109 ? 21.93699  -9.07669  1.93118   1.000 7.54497  ? 190  TYR A C   1 
ATOM   1212 O O   . TYR A 1 109 ? 21.33202  -10.00090 1.38043   1.000 7.77485  ? 190  TYR A O   1 
ATOM   1213 C CB  . TYR A 1 109 ? 22.47538  -7.02405  0.63963   1.000 8.46446  ? 190  TYR A CB  1 
ATOM   1214 C CG  . TYR A 1 109 ? 22.40033  -7.73506  -0.69166  1.000 7.15401  ? 190  TYR A CG  1 
ATOM   1215 C CD1 . TYR A 1 109 ? 21.40000  -7.42471  -1.58928  1.000 7.87518  ? 190  TYR A CD1 1 
ATOM   1216 C CD2 . TYR A 1 109 ? 23.30384  -8.72157  -1.04645  1.000 7.82967  ? 190  TYR A CD2 1 
ATOM   1217 C CE1 . TYR A 1 109 ? 21.30999  -8.05414  -2.81419  1.000 7.68332  ? 190  TYR A CE1 1 
ATOM   1218 C CE2 . TYR A 1 109 ? 23.22888  -9.35623  -2.28220  1.000 7.68457  ? 190  TYR A CE2 1 
ATOM   1219 C CZ  . TYR A 1 109 ? 22.23053  -9.02604  -3.16419  1.000 6.77672  ? 190  TYR A CZ  1 
ATOM   1220 O OH  . TYR A 1 109 ? 22.18018  -9.65776  -4.37843  1.000 7.56098  ? 190  TYR A OH  1 
ATOM   1221 N N   . GLU A 1 110 ? 22.94811  -9.29017  2.76537   1.000 8.19929  ? 191  GLU A N   1 
ATOM   1222 C CA  A GLU A 1 110 ? 23.35178  -10.65497 3.11897   0.715 8.48047  ? 191  GLU A CA  1 
ATOM   1223 C CA  B GLU A 1 110 ? 23.32161  -10.66181 3.02912   0.285 8.62883  ? 191  GLU A CA  1 
ATOM   1224 C C   . GLU A 1 110 ? 22.20823  -11.40634 3.76597   1.000 8.15284  ? 191  GLU A C   1 
ATOM   1225 O O   . GLU A 1 110 ? 21.99592  -12.59044 3.50008   1.000 8.69452  ? 191  GLU A O   1 
ATOM   1226 C CB  A GLU A 1 110 ? 24.54433  -10.64936 4.07773   0.715 8.98198  ? 191  GLU A CB  1 
ATOM   1227 C CB  B GLU A 1 110 ? 24.72456  -10.69358 3.63700   0.285 11.73014 ? 191  GLU A CB  1 
ATOM   1228 C CG  A GLU A 1 110 ? 25.83402  -10.23759 3.41275   0.715 8.75597  ? 191  GLU A CG  1 
ATOM   1229 C CG  B GLU A 1 110 ? 25.70986  -9.92347  2.71260   0.285 9.22204  ? 191  GLU A CG  1 
ATOM   1230 C CD  A GLU A 1 110 ? 26.99941  -10.05003 4.35842   0.715 9.73828  ? 191  GLU A CD  1 
ATOM   1231 C CD  B GLU A 1 110 ? 27.15047  -9.93284  3.18255   0.285 9.64333  ? 191  GLU A CD  1 
ATOM   1232 O OE1 A GLU A 1 110 ? 26.83422  -10.30300 5.56683   0.715 12.75521 ? 191  GLU A OE1 1 
ATOM   1233 O OE1 B GLU A 1 110 ? 27.41403  -10.45691 4.28313   0.285 13.88139 ? 191  GLU A OE1 1 
ATOM   1234 O OE2 A GLU A 1 110 ? 28.08116  -9.65280  3.87783   0.715 11.11701 ? 191  GLU A OE2 1 
ATOM   1235 O OE2 B GLU A 1 110 ? 28.02019  -9.39580  2.45793   0.285 12.14285 ? 191  GLU A OE2 1 
ATOM   1236 N N   . ASN A 1 111 ? 21.45439  -10.72350 4.62595   1.000 8.81242  ? 192  ASN A N   1 
ATOM   1237 C CA  . ASN A 1 111 ? 20.31350  -11.37041 5.25695   1.000 8.79661  ? 192  ASN A CA  1 
ATOM   1238 C C   . ASN A 1 111 ? 19.21736  -11.69420 4.23860   1.000 8.34327  ? 192  ASN A C   1 
ATOM   1239 O O   . ASN A 1 111 ? 18.56463  -12.73644 4.34266   1.000 8.97291  ? 192  ASN A O   1 
ATOM   1240 C CB  . ASN A 1 111 ? 19.80399  -10.49571 6.39243   1.000 9.73902  ? 192  ASN A CB  1 
ATOM   1241 C CG  . ASN A 1 111 ? 18.55261  -11.03163 6.98665   1.000 10.83814 ? 192  ASN A CG  1 
ATOM   1242 O OD1 . ASN A 1 111 ? 17.47043  -10.54763 6.68761   1.000 12.53998 ? 192  ASN A OD1 1 
ATOM   1243 N ND2 . ASN A 1 111 ? 18.67769  -12.07542 7.79723   1.000 13.49234 ? 192  ASN A ND2 1 
ATOM   1244 N N   . TYR A 1 112 ? 19.01422  -10.81795 3.24669   1.000 8.37382  ? 193  TYR A N   1 
ATOM   1245 C CA  . TYR A 1 112 ? 18.10399  -11.09760 2.13556   1.000 8.28868  ? 193  TYR A CA  1 
ATOM   1246 C C   . TYR A 1 112 ? 18.52224  -12.36765 1.39700   1.000 7.32367  ? 193  TYR A C   1 
ATOM   1247 O O   . TYR A 1 112 ? 17.70501  -13.26900 1.17332   1.000 7.80170  ? 193  TYR A O   1 
ATOM   1248 C CB  . TYR A 1 112 ? 18.04101  -9.84913  1.22917   1.000 8.53301  ? 193  TYR A CB  1 
ATOM   1249 C CG  . TYR A 1 112 ? 17.65894  -10.03194 -0.23011  1.000 7.70890  ? 193  TYR A CG  1 
ATOM   1250 C CD1 . TYR A 1 112 ? 16.33752  -9.97710  -0.66191  1.000 8.03515  ? 193  TYR A CD1 1 
ATOM   1251 C CD2 . TYR A 1 112 ? 18.63950  -10.20158 -1.18722  1.000 7.98799  ? 193  TYR A CD2 1 
ATOM   1252 C CE1 . TYR A 1 112 ? 16.01875  -10.12030 -2.00745  1.000 7.90338  ? 193  TYR A CE1 1 
ATOM   1253 C CE2 . TYR A 1 112 ? 18.33175  -10.34947 -2.51641  1.000 8.13079  ? 193  TYR A CE2 1 
ATOM   1254 C CZ  . TYR A 1 112 ? 17.02452  -10.30578 -2.93149  1.000 7.37661  ? 193  TYR A CZ  1 
ATOM   1255 O OH  . TYR A 1 112 ? 16.76141  -10.45983 -4.27587  1.000 8.40347  ? 193  TYR A OH  1 
ATOM   1256 N N   . ILE A 1 113 ? 19.81202  -12.48935 1.06817   1.000 7.31557  ? 194  ILE A N   1 
ATOM   1257 C CA  . ILE A 1 113 ? 20.30191  -13.71438 0.43857   1.000 7.38591  ? 194  ILE A CA  1 
ATOM   1258 C C   . ILE A 1 113 ? 20.09963  -14.90865 1.36437   1.000 7.07424  ? 194  ILE A C   1 
ATOM   1259 O O   . ILE A 1 113 ? 19.67241  -15.97985 0.92502   1.000 7.85983  ? 194  ILE A O   1 
ATOM   1260 C CB  . ILE A 1 113 ? 21.77904  -13.56503 0.02630   1.000 7.04680  ? 194  ILE A CB  1 
ATOM   1261 C CG1 . ILE A 1 113 ? 21.95153  -12.49944 -1.06353  1.000 7.37037  ? 194  ILE A CG1 1 
ATOM   1262 C CG2 . ILE A 1 113 ? 22.37293  -14.90662 -0.39001  1.000 7.92031  ? 194  ILE A CG2 1 
ATOM   1263 C CD1 . ILE A 1 113 ? 21.21151  -12.78158 -2.35350  1.000 8.08513  ? 194  ILE A CD1 1 
ATOM   1264 N N   . ASP A 1 114 ? 20.39659  -14.74533 2.65443   1.000 7.55958  ? 195  ASP A N   1 
ATOM   1265 C CA  . ASP A 1 114 ? 20.26670  -15.86424 3.58413   1.000 8.19357  ? 195  ASP A CA  1 
ATOM   1266 C C   . ASP A 1 114 ? 18.83199  -16.36884 3.62825   1.000 8.18409  ? 195  ASP A C   1 
ATOM   1267 O O   . ASP A 1 114 ? 18.59141  -17.57666 3.71173   1.000 8.84555  ? 195  ASP A O   1 
ATOM   1268 C CB  . ASP A 1 114 ? 20.70950  -15.44729 4.99139   1.000 9.12716  ? 195  ASP A CB  1 
ATOM   1269 C CG  . ASP A 1 114 ? 22.21258  -15.20702 5.11253   1.000 8.98204  ? 195  ASP A CG  1 
ATOM   1270 O OD1 . ASP A 1 114 ? 22.98479  -15.62700 4.22700   1.000 9.57262  ? 195  ASP A OD1 1 
ATOM   1271 O OD2 . ASP A 1 114 ? 22.60819  -14.57903 6.12560   1.000 11.57005 ? 195  ASP A OD2 1 
ATOM   1272 N N   . GLN A 1 115 ? 17.86226  -15.45059 3.58777   1.000 8.36631  ? 196  GLN A N   1 
ATOM   1273 C CA  . GLN A 1 115 ? 16.46355  -15.85838 3.61814   1.000 8.48155  ? 196  GLN A CA  1 
ATOM   1274 C C   . GLN A 1 115 ? 16.08281  -16.60109 2.34507   1.000 7.77153  ? 196  GLN A C   1 
ATOM   1275 O O   . GLN A 1 115 ? 15.28230  -17.54424 2.38842   1.000 8.72615  ? 196  GLN A O   1 
ATOM   1276 C CB  . GLN A 1 115 ? 15.55452  -14.64400 3.81451   1.000 9.40482  ? 196  GLN A CB  1 
ATOM   1277 C CG  . GLN A 1 115 ? 15.65441  -13.98678 5.17386   1.000 10.22471 ? 196  GLN A CG  1 
ATOM   1278 C CD  . GLN A 1 115 ? 14.63175  -12.87594 5.35819   1.000 11.23052 ? 196  GLN A CD  1 
ATOM   1279 O OE1 . GLN A 1 115 ? 13.45327  -13.04061 5.03581   1.000 13.24433 ? 196  GLN A OE1 1 
ATOM   1280 N NE2 . GLN A 1 115 ? 15.07977  -11.73234 5.84635   1.000 13.18963 ? 196  GLN A NE2 1 
ATOM   1281 N N   . ILE A 1 116 ? 16.62929  -16.18129 1.20242   1.000 7.94542  ? 197  ILE A N   1 
ATOM   1282 C CA  . ILE A 1 116 ? 16.39320  -16.88590 -0.05538  1.000 7.93894  ? 197  ILE A CA  1 
ATOM   1283 C C   . ILE A 1 116 ? 17.00304  -18.28161 -0.01537  1.000 8.02358  ? 197  ILE A C   1 
ATOM   1284 O O   . ILE A 1 116 ? 16.35307  -19.27068 -0.37869  1.000 8.18305  ? 197  ILE A O   1 
ATOM   1285 C CB  . ILE A 1 116 ? 16.93015  -16.05062 -1.23105  1.000 7.89807  ? 197  ILE A CB  1 
ATOM   1286 C CG1 . ILE A 1 116 ? 16.04104  -14.81878 -1.42901  1.000 8.40568  ? 197  ILE A CG1 1 
ATOM   1287 C CG2 . ILE A 1 116 ? 17.00442  -16.86567 -2.50577  1.000 7.99935  ? 197  ILE A CG2 1 
ATOM   1288 C CD1 . ILE A 1 116 ? 16.64530  -13.75076 -2.31945  1.000 10.00707 ? 197  ILE A CD1 1 
ATOM   1289 N N   . VAL A 1 117 ? 18.25736  -18.37728 0.43265   1.000 8.38145  ? 198  VAL A N   1 
ATOM   1290 C CA  . VAL A 1 117 ? 18.92085  -19.67329 0.55318   1.000 8.86022  ? 198  VAL A CA  1 
ATOM   1291 C C   . VAL A 1 117 ? 18.12494  -20.59645 1.46817   1.000 9.04928  ? 198  VAL A C   1 
ATOM   1292 O O   . VAL A 1 117 ? 17.96628  -21.78762 1.18557   1.000 9.63123  ? 198  VAL A O   1 
ATOM   1293 C CB  . VAL A 1 117 ? 20.36748  -19.47553 1.04506   1.000 9.03360  ? 198  VAL A CB  1 
ATOM   1294 C CG1 . VAL A 1 117 ? 20.99486  -20.79165 1.47754   1.000 11.03779 ? 198  VAL A CG1 1 
ATOM   1295 C CG2 . VAL A 1 117 ? 21.21644  -18.81351 -0.03073  1.000 11.00903 ? 198  VAL A CG2 1 
ATOM   1296 N N   . ALA A 1 118 ? 17.61117  -20.05645 2.58082   1.000 9.20874  ? 199  ALA A N   1 
ATOM   1297 C CA  . ALA A 1 118 ? 16.87554  -20.86914 3.54208   1.000 9.47216  ? 199  ALA A CA  1 
ATOM   1298 C C   . ALA A 1 118 ? 15.61343  -21.45958 2.92872   1.000 8.95147  ? 199  ALA A C   1 
ATOM   1299 O O   . ALA A 1 118 ? 15.21185  -22.57569 3.29462   1.000 10.10571 ? 199  ALA A O   1 
ATOM   1300 C CB  . ALA A 1 118 ? 16.53416  -20.04920 4.78988   1.000 11.32115 ? 199  ALA A CB  1 
ATOM   1301 N N   . GLN A 1 119 ? 14.96981  -20.72905 2.00827   1.000 8.38967  ? 200  GLN A N   1 
ATOM   1302 C CA  . GLN A 1 119 ? 13.84427  -21.29791 1.26584   1.000 8.60601  ? 200  GLN A CA  1 
ATOM   1303 C C   . GLN A 1 119 ? 14.30980  -22.38544 0.30183   1.000 8.28813  ? 200  GLN A C   1 
ATOM   1304 O O   . GLN A 1 119 ? 13.78208  -23.50508 0.30640   1.000 8.74018  ? 200  GLN A O   1 
ATOM   1305 C CB  . GLN A 1 119 ? 13.10074  -20.20694 0.49855   1.000 8.60642  ? 200  GLN A CB  1 
ATOM   1306 C CG  . GLN A 1 119 ? 12.33335  -19.24369 1.38529   1.000 8.19680  ? 200  GLN A CG  1 
ATOM   1307 C CD  . GLN A 1 119 ? 11.04804  -19.82156 1.93635   1.000 8.91748  ? 200  GLN A CD  1 
ATOM   1308 O OE1 . GLN A 1 119 ? 10.70418  -20.97399 1.68727   1.000 9.10566  ? 200  GLN A OE1 1 
ATOM   1309 N NE2 . GLN A 1 119 ? 10.31665  -19.00646 2.67934   1.000 10.05750 ? 200  GLN A NE2 1 
ATOM   1310 N N   . ILE A 1 120 ? 15.30499  -22.06777 -0.53165  1.000 8.10488  ? 201  ILE A N   1 
ATOM   1311 C CA  . ILE A 1 120 ? 15.74535  -22.98754 -1.58113  1.000 8.82831  ? 201  ILE A CA  1 
ATOM   1312 C C   . ILE A 1 120 ? 16.23134  -24.30846 -0.98813  1.000 9.18863  ? 201  ILE A C   1 
ATOM   1313 O O   . ILE A 1 120 ? 15.99083  -25.38915 -1.54993  1.000 9.99061  ? 201  ILE A O   1 
ATOM   1314 C CB  . ILE A 1 120 ? 16.80114  -22.30079 -2.47203  1.000 8.66982  ? 201  ILE A CB  1 
ATOM   1315 C CG1 . ILE A 1 120 ? 16.15448  -21.14719 -3.25919  1.000 8.67347  ? 201  ILE A CG1 1 
ATOM   1316 C CG2 . ILE A 1 120 ? 17.46466  -23.27995 -3.41252  1.000 8.86864  ? 201  ILE A CG2 1 
ATOM   1317 C CD1 . ILE A 1 120 ? 17.12359  -20.28150 -4.00995  1.000 8.93530  ? 201  ILE A CD1 1 
ATOM   1318 N N   . GLN A 1 121 ? 16.90029  -24.23546 0.16644   1.000 9.62464  ? 202  GLN A N   1 
ATOM   1319 C CA  A GLN A 1 121 ? 17.43969  -25.42749 0.80572   0.496 10.79823 ? 202  GLN A CA  1 
ATOM   1320 C CA  B GLN A 1 121 ? 17.42906  -25.41141 0.86535   0.504 10.78953 ? 202  GLN A CA  1 
ATOM   1321 C C   . GLN A 1 121 ? 16.35231  -26.44654 1.14323   1.000 9.55230  ? 202  GLN A C   1 
ATOM   1322 O O   . GLN A 1 121 ? 16.64164  -27.64970 1.22960   1.000 11.45932 ? 202  GLN A O   1 
ATOM   1323 C CB  A GLN A 1 121 ? 18.22099  -25.00529 2.05292   0.496 11.60960 ? 202  GLN A CB  1 
ATOM   1324 C CB  B GLN A 1 121 ? 18.00080  -24.99337 2.22610   0.504 14.67650 ? 202  GLN A CB  1 
ATOM   1325 C CG  A GLN A 1 121 ? 18.90915  -26.12977 2.78628   0.496 13.09385 ? 202  GLN A CG  1 
ATOM   1326 C CG  B GLN A 1 121 ? 19.33128  -24.29429 2.19820   0.504 19.21758 ? 202  GLN A CG  1 
ATOM   1327 C CD  A GLN A 1 121 ? 19.89479  -25.63061 3.81966   0.496 20.73475 ? 202  GLN A CD  1 
ATOM   1328 C CD  B GLN A 1 121 ? 20.00719  -24.23165 3.54901   0.504 19.37234 ? 202  GLN A CD  1 
ATOM   1329 O OE1 A GLN A 1 121 ? 19.66025  -25.74448 5.02242   0.496 26.72170 ? 202  GLN A OE1 1 
ATOM   1330 O OE1 B GLN A 1 121 ? 19.35290  -24.32062 4.58789   0.504 24.52871 ? 202  GLN A OE1 1 
ATOM   1331 N NE2 A GLN A 1 121 ? 21.01027  -25.07657 3.35508   0.496 22.31567 ? 202  GLN A NE2 1 
ATOM   1332 N NE2 B GLN A 1 121 ? 21.32680  -24.05618 3.54359   0.504 21.05112 ? 202  GLN A NE2 1 
ATOM   1333 N N   . GLN A 1 122 ? 15.11177  -26.00015 1.33599   1.000 9.16871  ? 203  GLN A N   1 
ATOM   1334 C CA  A GLN A 1 122 ? 14.05045  -26.90877 1.75084   0.820 10.21837 ? 203  GLN A CA  1 
ATOM   1335 C CA  B GLN A 1 122 ? 14.03525  -26.89661 1.74662   0.180 10.24511 ? 203  GLN A CA  1 
ATOM   1336 C C   . GLN A 1 122 ? 13.44033  -27.70356 0.60415   1.000 9.73380  ? 203  GLN A C   1 
ATOM   1337 O O   . GLN A 1 122 ? 12.68626  -28.64646 0.86864   1.000 11.45737 ? 203  GLN A O   1 
ATOM   1338 C CB  A GLN A 1 122 ? 12.96788  -26.15398 2.53218   0.820 10.71577 ? 203  GLN A CB  1 
ATOM   1339 C CB  B GLN A 1 122 ? 12.88989  -26.12412 2.40160   0.180 10.49603 ? 203  GLN A CB  1 
ATOM   1340 C CG  A GLN A 1 122 ? 13.48134  -25.52966 3.82231   0.820 10.39486 ? 203  GLN A CG  1 
ATOM   1341 C CG  B GLN A 1 122 ? 13.25866  -25.32921 3.62454   0.180 12.85355 ? 203  GLN A CG  1 
ATOM   1342 C CD  A GLN A 1 122 ? 12.43270  -24.69264 4.52379   0.820 9.66278  ? 203  GLN A CD  1 
ATOM   1343 C CD  B GLN A 1 122 ? 12.15436  -24.37605 4.01516   0.180 12.19880 ? 203  GLN A CD  1 
ATOM   1344 O OE1 A GLN A 1 122 ? 11.45670  -25.21010 5.07679   0.820 10.70785 ? 203  GLN A OE1 1 
ATOM   1345 O OE1 B GLN A 1 122 ? 11.04130  -24.79541 4.33310   0.180 14.30106 ? 203  GLN A OE1 1 
ATOM   1346 N NE2 A GLN A 1 122 ? 12.60299  -23.38068 4.46652   0.820 9.73727  ? 203  GLN A NE2 1 
ATOM   1347 N NE2 B GLN A 1 122 ? 12.44578  -23.08558 3.96878   0.180 13.05503 ? 203  GLN A NE2 1 
ATOM   1348 N N   . PHE A 1 123 ? 13.75760  -27.37154 -0.64354  1.000 9.84826  ? 204  PHE A N   1 
ATOM   1349 C CA  . PHE A 1 123 ? 13.11327  -27.98689 -1.80567  1.000 9.95756  ? 204  PHE A CA  1 
ATOM   1350 C C   . PHE A 1 123 ? 14.15357  -28.49125 -2.79631  1.000 10.39588 ? 204  PHE A C   1 
ATOM   1351 O O   . PHE A 1 123 ? 14.24916  -28.01071 -3.93345  1.000 10.58820 ? 204  PHE A O   1 
ATOM   1352 C CB  . PHE A 1 123 ? 12.13384  -27.00628 -2.44819  1.000 10.42892 ? 204  PHE A CB  1 
ATOM   1353 C CG  . PHE A 1 123 ? 11.15523  -26.41773 -1.46404  1.000 10.70457 ? 204  PHE A CG  1 
ATOM   1354 C CD1 . PHE A 1 123 ? 10.01388  -27.10946 -1.10011  1.000 12.66417 ? 204  PHE A CD1 1 
ATOM   1355 C CD2 . PHE A 1 123 ? 11.40622  -25.19646 -0.86452  1.000 10.49573 ? 204  PHE A CD2 1 
ATOM   1356 C CE1 . PHE A 1 123 ? 9.12865   -26.57699 -0.17702  1.000 13.28552 ? 204  PHE A CE1 1 
ATOM   1357 C CE2 . PHE A 1 123 ? 10.52707  -24.65614 0.05654   1.000 11.67525 ? 204  PHE A CE2 1 
ATOM   1358 C CZ  . PHE A 1 123 ? 9.39011   -25.35077 0.40018   1.000 14.02565 ? 204  PHE A CZ  1 
ATOM   1359 N N   . PRO A 1 124 ? 14.94982  -29.48441 -2.39607  1.000 11.39383 ? 205  PRO A N   1 
ATOM   1360 C CA  . PRO A 1 124 ? 16.04323  -29.92786 -3.26729  1.000 12.93049 ? 205  PRO A CA  1 
ATOM   1361 C C   . PRO A 1 124 ? 15.58430  -30.60447 -4.54414  1.000 11.25678 ? 205  PRO A C   1 
ATOM   1362 O O   . PRO A 1 124 ? 16.39942  -30.73057 -5.46738  1.000 13.42796 ? 205  PRO A O   1 
ATOM   1363 C CB  . PRO A 1 124 ? 16.85090  -30.87935 -2.37555  1.000 15.13142 ? 205  PRO A CB  1 
ATOM   1364 C CG  . PRO A 1 124 ? 15.87498  -31.35516 -1.36213  1.000 14.43695 ? 205  PRO A CG  1 
ATOM   1365 C CD  . PRO A 1 124 ? 14.93232  -30.21901 -1.11792  1.000 12.56123 ? 205  PRO A CD  1 
ATOM   1366 N N   . ASP A 1 125 ? 14.32780  -31.03738 -4.64680  1.000 10.70341 ? 206  ASP A N   1 
ATOM   1367 C CA  . ASP A 1 125 ? 13.87993  -31.64199 -5.89127  1.000 11.37006 ? 206  ASP A CA  1 
ATOM   1368 C C   . ASP A 1 125 ? 13.42076  -30.61926 -6.92405  1.000 10.02854 ? 206  ASP A C   1 
ATOM   1369 O O   . ASP A 1 125 ? 12.96149  -31.02086 -7.99686  1.000 11.62432 ? 206  ASP A O   1 
ATOM   1370 C CB  . ASP A 1 125 ? 12.84694  -32.76493 -5.66228  1.000 12.87472 ? 206  ASP A CB  1 
ATOM   1371 C CG  . ASP A 1 125 ? 11.43305  -32.27553 -5.41740  1.000 15.19539 ? 206  ASP A CG  1 
ATOM   1372 O OD1 . ASP A 1 125 ? 11.22685  -31.14184 -4.95856  1.000 15.23682 ? 206  ASP A OD1 1 
ATOM   1373 O OD2 . ASP A 1 125 ? 10.50508  -33.08145 -5.66654  1.000 18.43620 ? 206  ASP A OD2 1 
ATOM   1374 N N   . VAL A 1 126 ? 13.55993  -29.32346 -6.63888  1.000 8.74474  ? 207  VAL A N   1 
ATOM   1375 C CA  . VAL A 1 126 ? 13.23434  -28.25577 -7.57519  1.000 8.71900  ? 207  VAL A CA  1 
ATOM   1376 C C   . VAL A 1 126 ? 14.52419  -27.56956 -8.00459  1.000 8.13912  ? 207  VAL A C   1 
ATOM   1377 O O   . VAL A 1 126 ? 15.33582  -27.17826 -7.15714  1.000 10.15963 ? 207  VAL A O   1 
ATOM   1378 C CB  . VAL A 1 126 ? 12.25444  -27.25200 -6.94464  1.000 9.08410  ? 207  VAL A CB  1 
ATOM   1379 C CG1 . VAL A 1 126 ? 11.95297  -26.12319 -7.92632  1.000 9.04739  ? 207  VAL A CG1 1 
ATOM   1380 C CG2 . VAL A 1 126 ? 10.98296  -27.95162 -6.51484  1.000 9.82093  ? 207  VAL A CG2 1 
ATOM   1381 N N   . ARG A 1 127 ? 14.71718  -27.42680 -9.31449  1.000 7.42589  ? 208  ARG A N   1 
ATOM   1382 C CA  . ARG A 1 127 ? 15.86591  -26.68579 -9.82164  1.000 7.50146  ? 208  ARG A CA  1 
ATOM   1383 C C   . ARG A 1 127 ? 15.54461  -25.19778 -9.84024  1.000 7.22924  ? 208  ARG A C   1 
ATOM   1384 O O   . ARG A 1 127 ? 14.40467  -24.79923 -10.08451 1.000 7.43415  ? 208  ARG A O   1 
ATOM   1385 C CB  . ARG A 1 127 ? 16.22076  -27.15772 -11.23162 1.000 8.32716  ? 208  ARG A CB  1 
ATOM   1386 C CG  . ARG A 1 127 ? 17.37787  -26.40817 -11.86751 1.000 8.26044  ? 208  ARG A CG  1 
ATOM   1387 C CD  . ARG A 1 127 ? 17.93453  -27.13701 -13.05713 1.000 8.23967  ? 208  ARG A CD  1 
ATOM   1388 N NE  . ARG A 1 127 ? 18.72114  -28.29365 -12.65026 1.000 8.30040  ? 208  ARG A NE  1 
ATOM   1389 C CZ  . ARG A 1 127 ? 19.43816  -29.01879 -13.49266 1.000 8.07590  ? 208  ARG A CZ  1 
ATOM   1390 N NH1 . ARG A 1 127 ? 19.46290  -28.73643 -14.78271 1.000 8.93324  ? 208  ARG A NH1 1 
ATOM   1391 N NH2 . ARG A 1 127 ? 20.15338  -30.04191 -13.03248 1.000 10.04234 ? 208  ARG A NH2 1 
ATOM   1392 N N   . VAL A 1 128 ? 16.55366  -24.37423 -9.57341  1.000 7.00746  ? 209  VAL A N   1 
ATOM   1393 C CA  . VAL A 1 128 ? 16.40467  -22.92155 -9.58594  1.000 6.80127  ? 209  VAL A CA  1 
ATOM   1394 C C   . VAL A 1 128 ? 17.43973  -22.34029 -10.53517 1.000 6.61639  ? 209  VAL A C   1 
ATOM   1395 O O   . VAL A 1 128 ? 18.62150  -22.69833 -10.46473 1.000 7.06988  ? 209  VAL A O   1 
ATOM   1396 C CB  . VAL A 1 128 ? 16.54486  -22.31464 -8.17483  1.000 7.50696  ? 209  VAL A CB  1 
ATOM   1397 C CG1 . VAL A 1 128 ? 16.40516  -20.79878 -8.21979  1.000 7.89336  ? 209  VAL A CG1 1 
ATOM   1398 C CG2 . VAL A 1 128 ? 15.53971  -22.93655 -7.23321  1.000 8.55321  ? 209  VAL A CG2 1 
ATOM   1399 N N   . VAL A 1 129 ? 16.98838  -21.43908 -11.40999 1.000 6.51418  ? 210  VAL A N   1 
ATOM   1400 C CA  . VAL A 1 129 ? 17.86354  -20.61083 -12.23030 1.000 6.56713  ? 210  VAL A CA  1 
ATOM   1401 C C   . VAL A 1 129 ? 17.66681  -19.17265 -11.78951 1.000 6.17553  ? 210  VAL A C   1 
ATOM   1402 O O   . VAL A 1 129 ? 16.52493  -18.69161 -11.71913 1.000 7.23419  ? 210  VAL A O   1 
ATOM   1403 C CB  . VAL A 1 129 ? 17.57496  -20.75237 -13.73425 1.000 7.18034  ? 210  VAL A CB  1 
ATOM   1404 C CG1 . VAL A 1 129 ? 18.40687  -19.74675 -14.52753 1.000 8.83345  ? 210  VAL A CG1 1 
ATOM   1405 C CG2 . VAL A 1 129 ? 17.85036  -22.17744 -14.20178 1.000 8.43988  ? 210  VAL A CG2 1 
ATOM   1406 N N   . ALA A 1 130 ? 18.76597  -18.48005 -11.51850 1.000 6.74398  ? 211  ALA A N   1 
ATOM   1407 C CA  . ALA A 1 130 ? 18.73646  -17.09662 -11.06226 1.000 6.63711  ? 211  ALA A CA  1 
ATOM   1408 C C   . ALA A 1 130 ? 19.54001  -16.18509 -11.97398 1.000 6.28607  ? 211  ALA A C   1 
ATOM   1409 O O   . ALA A 1 130 ? 20.68685  -16.48806 -12.31174 1.000 7.63560  ? 211  ALA A O   1 
ATOM   1410 C CB  . ALA A 1 130 ? 19.27230  -16.97961 -9.63613  1.000 7.69305  ? 211  ALA A CB  1 
ATOM   1411 N N   . VAL A 1 131 ? 18.93759  -15.06008 -12.33917 1.000 6.60848  ? 212  VAL A N   1 
ATOM   1412 C CA  . VAL A 1 131 ? 19.65826  -13.92333 -12.90856 1.000 6.47367  ? 212  VAL A CA  1 
ATOM   1413 C C   . VAL A 1 131 ? 20.12935  -13.04755 -11.75510 1.000 6.44271  ? 212  VAL A C   1 
ATOM   1414 O O   . VAL A 1 131 ? 19.33273  -12.67738 -10.88173 1.000 7.21805  ? 212  VAL A O   1 
ATOM   1415 C CB  . VAL A 1 131 ? 18.76283  -13.12296 -13.87635 1.000 6.85174  ? 212  VAL A CB  1 
ATOM   1416 C CG1 . VAL A 1 131 ? 19.43063  -11.79208 -14.25490 1.000 7.67421  ? 212  VAL A CG1 1 
ATOM   1417 C CG2 . VAL A 1 131 ? 18.47113  -13.93717 -15.12219 1.000 7.81098  ? 212  VAL A CG2 1 
ATOM   1418 N N   . ILE A 1 132 ? 21.41804  -12.72566 -11.73856 1.000 6.60472  ? 213  ILE A N   1 
ATOM   1419 C CA  . ILE A 1 132 ? 22.02030  -12.00839 -10.61780 1.000 6.76067  ? 213  ILE A CA  1 
ATOM   1420 C C   . ILE A 1 132 ? 22.12890  -10.51689 -10.93760 1.000 6.76928  ? 213  ILE A C   1 
ATOM   1421 O O   . ILE A 1 132 ? 22.96882  -10.10097 -11.74595 1.000 6.92148  ? 213  ILE A O   1 
ATOM   1422 C CB  . ILE A 1 132 ? 23.38096  -12.58735 -10.21442 1.000 7.47288  ? 213  ILE A CB  1 
ATOM   1423 C CG1 . ILE A 1 132 ? 23.30588  -14.10816 -10.01095 1.000 7.83288  ? 213  ILE A CG1 1 
ATOM   1424 C CG2 . ILE A 1 132 ? 23.88096  -11.88172 -8.95949  1.000 8.17707  ? 213  ILE A CG2 1 
ATOM   1425 C CD1 . ILE A 1 132 ? 22.33876  -14.56035 -8.92159  1.000 8.72004  ? 213  ILE A CD1 1 
ATOM   1426 N N   . GLU A 1 133 ? 21.29017  -9.72126  -10.25481 1.000 6.76897  ? 214  GLU A N   1 
ATOM   1427 C CA  . GLU A 1 133 ? 21.37424  -8.26221  -10.12566 1.000 6.74082  ? 214  GLU A CA  1 
ATOM   1428 C C   . GLU A 1 133 ? 21.48921  -7.50614  -11.44362 1.000 6.88743  ? 214  GLU A C   1 
ATOM   1429 O O   . GLU A 1 133 ? 22.54355  -6.94898  -11.78129 1.000 7.25187  ? 214  GLU A O   1 
ATOM   1430 C CB  . GLU A 1 133 ? 22.46371  -7.87907  -9.12178  1.000 7.22762  ? 214  GLU A CB  1 
ATOM   1431 C CG  . GLU A 1 133 ? 22.15536  -8.38202  -7.71353  1.000 7.22589  ? 214  GLU A CG  1 
ATOM   1432 C CD  . GLU A 1 133 ? 20.98639  -7.67897  -7.01620  1.000 6.73383  ? 214  GLU A CD  1 
ATOM   1433 O OE1 . GLU A 1 133 ? 20.50222  -6.63259  -7.49404  1.000 7.44628  ? 214  GLU A OE1 1 
ATOM   1434 O OE2 . GLU A 1 133 ? 20.56429  -8.18653  -5.94957  1.000 7.62422  ? 214  GLU A OE2 1 
ATOM   1435 N N   . PRO A 1 134 ? 20.39178  -7.41362  -12.18513 1.000 7.17115  ? 215  PRO A N   1 
ATOM   1436 C CA  . PRO A 1 134 ? 20.33884  -6.50215  -13.32653 1.000 7.58083  ? 215  PRO A CA  1 
ATOM   1437 C C   . PRO A 1 134 ? 20.78969  -5.09785  -12.94271 1.000 7.42792  ? 215  PRO A C   1 
ATOM   1438 O O   . PRO A 1 134 ? 20.58811  -4.64091  -11.81498 1.000 8.44824  ? 215  PRO A O   1 
ATOM   1439 C CB  . PRO A 1 134 ? 18.86001  -6.54236  -13.73741 1.000 8.34694  ? 215  PRO A CB  1 
ATOM   1440 C CG  . PRO A 1 134 ? 18.42355  -7.92086  -13.30425 1.000 8.25458  ? 215  PRO A CG  1 
ATOM   1441 C CD  . PRO A 1 134 ? 19.11708  -8.12235  -11.99111 1.000 7.59509  ? 215  PRO A CD  1 
ATOM   1442 N N   A ASP A 1 135 ? 21.34885  -4.37326  -13.89547 0.823 8.71860  ? 216  ASP A N   1 
ATOM   1443 N N   B ASP A 1 135 ? 21.48194  -4.47690  -13.91592 0.177 9.21278  ? 216  ASP A N   1 
ATOM   1444 C CA  A ASP A 1 135 ? 21.66366  -2.96263  -13.66677 0.823 9.21338  ? 216  ASP A CA  1 
ATOM   1445 C CA  B ASP A 1 135 ? 21.97964  -3.10014  -13.99987 0.177 13.95267 ? 216  ASP A CA  1 
ATOM   1446 C C   A ASP A 1 135 ? 22.62173  -2.77947  -12.48368 0.823 7.53696  ? 216  ASP A C   1 
ATOM   1447 C C   B ASP A 1 135 ? 23.31119  -2.86431  -13.29444 0.177 12.10305 ? 216  ASP A C   1 
ATOM   1448 O O   A ASP A 1 135 ? 22.47828  -1.82435  -11.71461 0.823 9.10558  ? 216  ASP A O   1 
ATOM   1449 O O   B ASP A 1 135 ? 24.09185  -1.99135  -13.68085 0.177 12.48864 ? 216  ASP A O   1 
ATOM   1450 C CB  A ASP A 1 135 ? 20.38392  -2.12711  -13.49922 0.823 9.52766  ? 216  ASP A CB  1 
ATOM   1451 C CB  B ASP A 1 135 ? 20.90781  -2.07898  -13.61720 0.177 13.19871 ? 216  ASP A CB  1 
ATOM   1452 C CG  A ASP A 1 135 ? 20.62476  -0.64604  -13.65849 0.823 10.31228 ? 216  ASP A CG  1 
ATOM   1453 C CG  B ASP A 1 135 ? 19.81656  -1.98477  -14.65935 0.177 14.35736 ? 216  ASP A CG  1 
ATOM   1454 O OD1 A ASP A 1 135 ? 21.56837  -0.26192  -14.37389 0.823 11.74904 ? 216  ASP A OD1 1 
ATOM   1455 O OD1 B ASP A 1 135 ? 20.02148  -2.51818  -15.77316 0.177 15.28860 ? 216  ASP A OD1 1 
ATOM   1456 O OD2 A ASP A 1 135 ? 19.87759  0.15578   -13.05690 0.823 11.90324 ? 216  ASP A OD2 1 
ATOM   1457 O OD2 B ASP A 1 135 ? 18.76384  -1.37874  -14.37530 0.177 16.74383 ? 216  ASP A OD2 1 
ATOM   1458 N N   . SER A 1 136 ? 23.59485  -3.70439  -12.31613 1.000 8.29562  ? 217  SER A N   1 
ATOM   1459 C CA  . SER A 1 136 ? 24.61922  -3.54801  -11.28375 1.000 8.58912  ? 217  SER A CA  1 
ATOM   1460 C C   . SER A 1 136 ? 26.03931  -3.52771  -11.83528 1.000 7.72324  ? 217  SER A C   1 
ATOM   1461 O O   . SER A 1 136 ? 26.59861  -2.44717  -12.04309 1.000 9.05886  ? 217  SER A O   1 
ATOM   1462 C CB  . SER A 1 136 ? 24.44041  -4.60920  -10.18762 1.000 9.14569  ? 217  SER A CB  1 
ATOM   1463 O OG  . SER A 1 136 ? 24.72081  -5.92929  -10.62118 1.000 8.68080  ? 217  SER A OG  1 
ATOM   1464 N N   . LEU A 1 137 ? 26.61096  -4.70687  -12.08383 1.000 7.94363  ? 218  LEU A N   1 
ATOM   1465 C CA  . LEU A 1 137 ? 27.99595  -4.80925  -12.53362 1.000 8.92977  ? 218  LEU A CA  1 
ATOM   1466 C C   . LEU A 1 137 ? 28.25095  -4.02500  -13.81236 1.000 7.97446  ? 218  LEU A C   1 
ATOM   1467 O O   . LEU A 1 137 ? 29.34509  -3.47870  -13.99453 1.000 8.16867  ? 218  LEU A O   1 
ATOM   1468 C CB  . LEU A 1 137 ? 28.37702  -6.27815  -12.72720 1.000 9.44521  ? 218  LEU A CB  1 
ATOM   1469 C CG  . LEU A 1 137 ? 28.32788  -7.19747  -11.50867 1.000 10.02040 ? 218  LEU A CG  1 
ATOM   1470 C CD1 . LEU A 1 137 ? 28.69363  -8.61548  -11.91199 1.000 11.31416 ? 218  LEU A CD1 1 
ATOM   1471 C CD2 . LEU A 1 137 ? 29.25679  -6.70376  -10.42821 1.000 13.26226 ? 218  LEU A CD2 1 
ATOM   1472 N N   A ALA A 1 138 ? 27.27843  -3.96998  -14.72269 0.785 7.75546  ? 219  ALA A N   1 
ATOM   1473 N N   B ALA A 1 138 ? 27.25613  -3.92866  -14.69583 0.215 7.75666  ? 219  ALA A N   1 
ATOM   1474 C CA  A ALA A 1 138 ? 27.50543  -3.21561  -15.95250 0.785 7.93188  ? 219  ALA A CA  1 
ATOM   1475 C CA  B ALA A 1 138 ? 27.45367  -3.17972  -15.93287 0.215 8.05362  ? 219  ALA A CA  1 
ATOM   1476 C C   A ALA A 1 138 ? 27.80239  -1.74481  -15.66383 0.785 7.64567  ? 219  ALA A C   1 
ATOM   1477 C C   B ALA A 1 138 ? 27.80259  -1.71627  -15.66586 0.215 7.72289  ? 219  ALA A C   1 
ATOM   1478 O O   A ALA A 1 138 ? 28.60552  -1.12317  -16.37218 0.785 8.17966  ? 219  ALA A O   1 
ATOM   1479 O O   B ALA A 1 138 ? 28.48600  -1.08500  -16.48104 0.215 8.00669  ? 219  ALA A O   1 
ATOM   1480 C CB  A ALA A 1 138 ? 26.31044  -3.36186  -16.89112 0.785 8.64242  ? 219  ALA A CB  1 
ATOM   1481 C CB  B ALA A 1 138 ? 26.22174  -3.30708  -16.82722 0.215 8.66000  ? 219  ALA A CB  1 
ATOM   1482 N N   A ASN A 1 139 ? 27.18449  -1.18018  -14.61514 0.785 7.49233  ? 220  ASN A N   1 
ATOM   1483 N N   B ASN A 1 139 ? 27.35243  -1.16305  -14.53269 0.215 7.39565  ? 220  ASN A N   1 
ATOM   1484 C CA  A ASN A 1 139 ? 27.48516  0.19456   -14.21781 0.785 8.58079  ? 220  ASN A CA  1 
ATOM   1485 C CA  B ASN A 1 139 ? 27.75835  0.18893   -14.15082 0.215 7.56735  ? 220  ASN A CA  1 
ATOM   1486 C C   A ASN A 1 139 ? 28.92970  0.36379   -13.77262 0.785 8.63514  ? 220  ASN A C   1 
ATOM   1487 C C   B ASN A 1 139 ? 29.23483  0.24515   -13.80170 0.215 7.21472  ? 220  ASN A C   1 
ATOM   1488 O O   A ASN A 1 139 ? 29.48543  1.46434   -13.87596 0.785 8.42267  ? 220  ASN A O   1 
ATOM   1489 O O   B ASN A 1 139 ? 29.91952  1.22688   -14.11194 0.215 8.80625  ? 220  ASN A O   1 
ATOM   1490 C CB  A ASN A 1 139 ? 26.56660  0.65262   -13.08655 0.785 9.15890  ? 220  ASN A CB  1 
ATOM   1491 C CB  B ASN A 1 139 ? 26.94993  0.67132   -12.94930 0.215 6.12278  ? 220  ASN A CB  1 
ATOM   1492 C CG  A ASN A 1 139 ? 25.16098  0.89103   -13.55357 0.785 9.12881  ? 220  ASN A CG  1 
ATOM   1493 C CG  B ASN A 1 139 ? 25.47433  0.74561   -13.23059 0.215 5.48660  ? 220  ASN A CG  1 
ATOM   1494 O OD1 A ASN A 1 139 ? 24.92286  1.74881   -14.40180 0.785 9.81026  ? 220  ASN A OD1 1 
ATOM   1495 O OD1 B ASN A 1 139 ? 25.00213  1.67240   -13.88306 0.215 7.05267  ? 220  ASN A OD1 1 
ATOM   1496 N ND2 A ASN A 1 139 ? 24.21323  0.14360   -13.00204 0.785 12.64033 ? 220  ASN A ND2 1 
ATOM   1497 N ND2 B ASN A 1 139 ? 24.73072  -0.23095  -12.74063 0.215 5.53477  ? 220  ASN A ND2 1 
ATOM   1498 N N   A LEU A 1 140 ? 29.54999  -0.69539  -13.26798 0.785 8.91988  ? 221  LEU A N   1 
ATOM   1499 N N   B LEU A 1 140 ? 29.73639  -0.78732  -13.13406 0.215 10.36495 ? 221  LEU A N   1 
ATOM   1500 C CA  A LEU A 1 140 ? 30.93154  -0.59666  -12.82283 0.785 9.73427  ? 221  LEU A CA  1 
ATOM   1501 C CA  B LEU A 1 140 ? 31.14332  -0.85452  -12.77440 0.215 9.01885  ? 221  LEU A CA  1 
ATOM   1502 C C   A LEU A 1 140 ? 31.92147  -0.66063  -13.97995 0.785 10.37141 ? 221  LEU A C   1 
ATOM   1503 C C   B LEU A 1 140 ? 32.03944  -0.94019  -13.98865 0.215 9.33473  ? 221  LEU A C   1 
ATOM   1504 O O   A LEU A 1 140 ? 33.10463  -0.37428  -13.77483 0.785 12.54167 ? 221  LEU A O   1 
ATOM   1505 O O   B LEU A 1 140 ? 33.26623  -0.96002  -13.83519 0.215 7.69832  ? 221  LEU A O   1 
ATOM   1506 C CB  A LEU A 1 140 ? 31.21855  -1.67578  -11.77970 0.785 9.41091  ? 221  LEU A CB  1 
ATOM   1507 C CB  B LEU A 1 140 ? 31.38922  -2.06240  -11.87626 0.215 10.72943 ? 221  LEU A CB  1 
ATOM   1508 C CG  A LEU A 1 140 ? 30.23573  -1.72490  -10.60251 0.785 9.27014  ? 221  LEU A CG  1 
ATOM   1509 C CG  B LEU A 1 140 ? 30.39386  -2.21876  -10.73379 0.215 10.86577 ? 221  LEU A CG  1 
ATOM   1510 C CD1 A LEU A 1 140 ? 30.66893  -2.79975  -9.61846  0.785 9.98474  ? 221  LEU A CD1 1 
ATOM   1511 C CD1 B LEU A 1 140 ? 30.84124  -3.33704  -9.83182  0.215 8.88858  ? 221  LEU A CD1 1 
ATOM   1512 C CD2 A LEU A 1 140 ? 30.13583  -0.36659  -9.92407  0.785 10.09663 ? 221  LEU A CD2 1 
ATOM   1513 C CD2 B LEU A 1 140 ? 30.24754  -0.91747  -9.95836  0.215 10.77752 ? 221  LEU A CD2 1 
ATOM   1514 N N   . VAL A 1 141 ? 31.46002  -1.00475  -15.18353 1.000 9.50251  ? 222  VAL A N   1 
ATOM   1515 C CA  . VAL A 1 141 ? 32.28330  -0.93120  -16.37781 1.000 10.21224 ? 222  VAL A CA  1 
ATOM   1516 C C   . VAL A 1 141 ? 32.28864  0.49787   -16.90711 1.000 10.06933 ? 222  VAL A C   1 
ATOM   1517 O O   . VAL A 1 141 ? 33.34471  1.13086   -16.99582 1.000 11.64384 ? 222  VAL A O   1 
ATOM   1518 C CB  . VAL A 1 141 ? 31.83940  -1.94688  -17.44749 1.000 9.29490  ? 222  VAL A CB  1 
ATOM   1519 C CG1 . VAL A 1 141 ? 32.76489  -1.86344  -18.65663 1.000 11.15452 ? 222  VAL A CG1 1 
ATOM   1520 C CG2 . VAL A 1 141 ? 31.84318  -3.36361  -16.87089 1.000 10.63165 ? 222  VAL A CG2 1 
ATOM   1521 N N   A THR A 1 142 ? 31.11849  1.02791   -17.25741 0.664 8.95244  ? 223  THR A N   1 
ATOM   1522 N N   B THR A 1 142 ? 31.10428  1.04984   -17.18466 0.336 8.92408  ? 223  THR A N   1 
ATOM   1523 C CA  A THR A 1 142 ? 31.05061  2.26196   -18.03579 0.664 9.74594  ? 223  THR A CA  1 
ATOM   1524 C CA  B THR A 1 142 ? 30.99938  2.33300   -17.87761 0.336 9.46456  ? 223  THR A CA  1 
ATOM   1525 C C   A THR A 1 142 ? 30.67897  3.49863   -17.22959 0.664 9.35553  ? 223  THR A C   1 
ATOM   1526 C C   B THR A 1 142 ? 30.68050  3.53356   -16.98965 0.336 10.26703 ? 223  THR A C   1 
ATOM   1527 O O   A THR A 1 142 ? 30.77695  4.61377   -17.76212 0.664 9.87887  ? 223  THR A O   1 
ATOM   1528 O O   B THR A 1 142 ? 30.91029  4.66989   -17.42226 0.336 11.93826 ? 223  THR A O   1 
ATOM   1529 C CB  A THR A 1 142 ? 30.02496  2.13067   -19.16505 0.664 10.33291 ? 223  THR A CB  1 
ATOM   1530 C CB  B THR A 1 142 ? 29.95257  2.26380   -19.00000 0.336 9.26241  ? 223  THR A CB  1 
ATOM   1531 O OG1 A THR A 1 142 ? 28.72191  2.00855   -18.59199 0.664 9.13598  ? 223  THR A OG1 1 
ATOM   1532 O OG1 B THR A 1 142 ? 28.63985  2.20804   -18.42665 0.336 9.47426  ? 223  THR A OG1 1 
ATOM   1533 C CG2 A THR A 1 142 ? 30.31551  0.92405   -20.03881 0.664 10.15648 ? 223  THR A CG2 1 
ATOM   1534 C CG2 B THR A 1 142 ? 30.18216  1.06321   -19.89985 0.336 9.32821  ? 223  THR A CG2 1 
ATOM   1535 N N   A ASN A 1 143 ? 30.24501  3.34497   -15.97937 0.664 8.81760  ? 224  ASN A N   1 
ATOM   1536 N N   B ASN A 1 143 ? 30.15714  3.33392   -15.77994 0.336 10.09890 ? 224  ASN A N   1 
ATOM   1537 C CA  A ASN A 1 143 ? 29.57549  4.43122   -15.26964 0.664 9.79634  ? 224  ASN A CA  1 
ATOM   1538 C CA  B ASN A 1 143 ? 29.62290  4.44177   -14.99486 0.336 9.43125  ? 224  ASN A CA  1 
ATOM   1539 C C   A ASN A 1 143 ? 30.24686  4.79825   -13.95093 0.664 9.33050  ? 224  ASN A C   1 
ATOM   1540 C C   B ASN A 1 143 ? 30.43929  4.74033   -13.73733 0.336 10.17283 ? 224  ASN A C   1 
ATOM   1541 O O   A ASN A 1 143 ? 29.60154  5.33889   -13.05531 0.664 9.54599  ? 224  ASN A O   1 
ATOM   1542 O O   B ASN A 1 143 ? 29.89730  5.24202   -12.75123 0.336 10.13537 ? 224  ASN A O   1 
ATOM   1543 C CB  A ASN A 1 143 ? 28.09018  4.13720   -15.06340 0.664 9.75331  ? 224  ASN A CB  1 
ATOM   1544 C CB  B ASN A 1 143 ? 28.14689  4.22705   -14.64910 0.336 8.94574  ? 224  ASN A CB  1 
ATOM   1545 C CG  A ASN A 1 143 ? 27.33310  4.03603   -16.36886 0.664 10.30514 ? 224  ASN A CG  1 
ATOM   1546 C CG  B ASN A 1 143 ? 27.22884  4.41348   -15.85035 0.336 8.33045  ? 224  ASN A CG  1 
ATOM   1547 O OD1 A ASN A 1 143 ? 27.76705  4.56369   -17.39251 0.664 10.76039 ? 224  ASN A OD1 1 
ATOM   1548 O OD1 B ASN A 1 143 ? 27.42470  5.31733   -16.66222 0.336 10.08900 ? 224  ASN A OD1 1 
ATOM   1549 N ND2 A ASN A 1 143 ? 26.19345  3.35651   -16.34176 0.664 11.43718 ? 224  ASN A ND2 1 
ATOM   1550 N ND2 B ASN A 1 143 ? 26.19131  3.58711   -15.93702 0.336 9.70393  ? 224  ASN A ND2 1 
ATOM   1551 N N   A LEU A 1 144 ? 31.55209  4.55642   -13.82765 0.664 9.85217  ? 225  LEU A N   1 
ATOM   1552 N N   B LEU A 1 144 ? 31.74609  4.46810   -13.75896 0.336 9.73534  ? 225  LEU A N   1 
ATOM   1553 C CA  A LEU A 1 144 ? 32.26041  4.96058   -12.61990 0.664 10.48018 ? 225  LEU A CA  1 
ATOM   1554 C CA  B LEU A 1 144 ? 32.57250  4.75672   -12.59170 0.336 10.28493 ? 225  LEU A CA  1 
ATOM   1555 C C   A LEU A 1 144 ? 32.41331  6.47268   -12.50503 0.664 10.72799 ? 225  LEU A C   1 
ATOM   1556 C C   B LEU A 1 144 ? 32.70633  6.24644   -12.31158 0.336 11.65201 ? 225  LEU A C   1 
ATOM   1557 O O   A LEU A 1 144 ? 32.77692  6.95123   -11.42607 0.664 10.50538 ? 225  LEU A O   1 
ATOM   1558 O O   B LEU A 1 144 ? 33.23232  6.61714   -11.25751 0.336 12.66045 ? 225  LEU A O   1 
ATOM   1559 C CB  A LEU A 1 144 ? 33.61180  4.24262   -12.51008 0.664 11.47009 ? 225  LEU A CB  1 
ATOM   1560 C CB  B LEU A 1 144 ? 33.94643  4.09945   -12.72325 0.336 10.90025 ? 225  LEU A CB  1 
ATOM   1561 C CG  A LEU A 1 144 ? 33.55689  2.72661   -12.28618 0.664 11.96290 ? 225  LEU A CG  1 
ATOM   1562 C CG  B LEU A 1 144 ? 33.91599  2.57407   -12.64314 0.336 12.45230 ? 225  LEU A CG  1 
ATOM   1563 C CD1 A LEU A 1 144 ? 34.96143  2.14458   -12.21271 0.664 15.25737 ? 225  LEU A CD1 1 
ATOM   1564 C CD1 B LEU A 1 144 ? 35.32089  2.02745   -12.54359 0.336 14.62383 ? 225  LEU A CD1 1 
ATOM   1565 C CD2 A LEU A 1 144 ? 32.76284  2.37812   -11.02903 0.664 13.24618 ? 225  LEU A CD2 1 
ATOM   1566 C CD2 B LEU A 1 144 ? 33.09573  2.13627   -11.44185 0.336 11.15522 ? 225  LEU A CD2 1 
ATOM   1567 N N   A ASN A 1 145 ? 32.14050  7.23035   -13.57818 0.664 9.73602  ? 226  ASN A N   1 
ATOM   1568 N N   B ASN A 1 145 ? 32.23448  7.10108   -13.21505 0.336 10.80489 ? 226  ASN A N   1 
ATOM   1569 C CA  A ASN A 1 145 ? 32.05148  8.68453   -13.47184 0.664 11.13985 ? 226  ASN A CA  1 
ATOM   1570 C CA  B ASN A 1 145 ? 32.27094  8.53653   -13.01311 0.336 12.42213 ? 226  ASN A CA  1 
ATOM   1571 C C   A ASN A 1 145 ? 30.76109  9.14299   -12.80132 0.664 10.64806 ? 226  ASN A C   1 
ATOM   1572 C C   B ASN A 1 145 ? 30.94688  9.07377   -12.50186 0.336 11.43856 ? 226  ASN A C   1 
ATOM   1573 O O   A ASN A 1 145 ? 30.65898  10.31817  -12.42053 0.664 10.39142 ? 226  ASN A O   1 
ATOM   1574 O O   B ASN A 1 145 ? 30.90557  10.20085  -11.98927 0.336 10.55646 ? 226  ASN A O   1 
ATOM   1575 C CB  A ASN A 1 145 ? 32.23897  9.36517   -14.83552 0.664 10.96849 ? 226  ASN A CB  1 
ATOM   1576 C CB  B ASN A 1 145 ? 32.63838  9.21437   -14.32700 0.336 12.69127 ? 226  ASN A CB  1 
ATOM   1577 C CG  A ASN A 1 145 ? 31.30210  8.82960   -15.91047 0.664 10.17510 ? 226  ASN A CG  1 
ATOM   1578 C CG  B ASN A 1 145 ? 34.09535  9.05059   -14.64363 0.336 12.85689 ? 226  ASN A CG  1 
ATOM   1579 O OD1 A ASN A 1 145 ? 31.10628  7.61310   -16.04713 0.664 12.12849 ? 226  ASN A OD1 1 
ATOM   1580 O OD1 B ASN A 1 145 ? 34.46183  8.36228   -15.59555 0.336 17.38299 ? 226  ASN A OD1 1 
ATOM   1581 N ND2 A ASN A 1 145 ? 30.74074  9.74475   -16.70682 0.664 11.84648 ? 226  ASN A ND2 1 
ATOM   1582 N ND2 B ASN A 1 145 ? 34.94047  9.60975   -13.80028 0.336 9.94825  ? 226  ASN A ND2 1 
ATOM   1583 N N   A VAL A 1 146 ? 29.79012  8.24871   -12.63452 0.664 11.74136 ? 227  VAL A N   1 
ATOM   1584 N N   B VAL A 1 146 ? 29.86896  8.29733   -12.64698 0.336 11.85157 ? 227  VAL A N   1 
ATOM   1585 C CA  A VAL A 1 146 ? 28.58061  8.54087   -11.87240 0.664 11.95660 ? 227  VAL A CA  1 
ATOM   1586 C CA  B VAL A 1 146 ? 28.66564  8.55457   -11.87244 0.336 11.95850 ? 227  VAL A CA  1 
ATOM   1587 C C   A VAL A 1 146 ? 28.93018  8.33815   -10.40146 0.664 11.06672 ? 227  VAL A C   1 
ATOM   1588 C C   B VAL A 1 146 ? 29.04525  8.35987   -10.41658 0.336 11.22794 ? 227  VAL A C   1 
ATOM   1589 O O   A VAL A 1 146 ? 29.21182  7.21634   -9.97765  0.664 10.12681 ? 227  VAL A O   1 
ATOM   1590 O O   B VAL A 1 146 ? 29.47183  7.26944   -10.01506 0.336 10.94398 ? 227  VAL A O   1 
ATOM   1591 C CB  A VAL A 1 146 ? 27.43451  7.61717   -12.29663 0.664 11.53890 ? 227  VAL A CB  1 
ATOM   1592 C CB  B VAL A 1 146 ? 27.55003  7.58475   -12.26712 0.336 11.42905 ? 227  VAL A CB  1 
ATOM   1593 C CG1 A VAL A 1 146 ? 26.14360  7.99361   -11.58342 0.664 12.59249 ? 227  VAL A CG1 1 
ATOM   1594 C CG1 B VAL A 1 146 ? 26.39846  7.65884   -11.26276 0.336 14.41232 ? 227  VAL A CG1 1 
ATOM   1595 C CG2 A VAL A 1 146 ? 27.26945  7.63010   -13.81786 0.664 11.79076 ? 227  VAL A CG2 1 
ATOM   1596 C CG2 B VAL A 1 146 ? 27.07683  7.83342   -13.68507 0.336 13.43663 ? 227  VAL A CG2 1 
ATOM   1597 N N   . GLN A 1 147 ? 28.92946  9.42115   -9.62107  1.000 12.45806 ? 228  GLN A N   1 
ATOM   1598 C CA  . GLN A 1 147 ? 29.41971  9.33757   -8.24698  1.000 12.46353 ? 228  GLN A CA  1 
ATOM   1599 C C   . GLN A 1 147 ? 28.69574  8.29039   -7.40674  1.000 11.30499 ? 228  GLN A C   1 
ATOM   1600 O O   . GLN A 1 147 ? 29.33211  7.59267   -6.61106  1.000 11.49516 ? 228  GLN A O   1 
ATOM   1601 C CB  . GLN A 1 147 ? 29.48934  10.71653  -7.59559  1.000 14.77354 ? 228  GLN A CB  1 
ATOM   1602 C CG  . GLN A 1 147 ? 30.38943  11.63901  -8.37735  1.000 19.18674 ? 228  GLN A CG  1 
ATOM   1603 C CD  . GLN A 1 147 ? 31.75308  11.00575  -8.61600  1.000 16.78523 ? 228  GLN A CD  1 
ATOM   1604 O OE1 . GLN A 1 147 ? 32.54250  10.84025  -7.68444  1.000 23.83895 ? 228  GLN A OE1 1 
ATOM   1605 N NE2 . GLN A 1 147 ? 31.99097  10.55406  -9.83803  1.000 23.90675 ? 228  GLN A NE2 1 
ATOM   1606 N N   . LYS A 1 148 ? 27.38550  8.13603   -7.58150  1.000 11.45506 ? 229  LYS A N   1 
ATOM   1607 C CA  . LYS A 1 148 ? 26.68804  7.10580   -6.81618  1.000 11.90763 ? 229  LYS A CA  1 
ATOM   1608 C C   . LYS A 1 148 ? 27.21657  5.71497   -7.15064  1.000 10.33268 ? 229  LYS A C   1 
ATOM   1609 O O   . LYS A 1 148 ? 27.30532  4.84225   -6.27568  1.000 10.45712 ? 229  LYS A O   1 
ATOM   1610 C CB  . LYS A 1 148 ? 25.17945  7.18560   -7.04630  1.000 12.02007 ? 229  LYS A CB  1 
ATOM   1611 C CG  . LYS A 1 148 ? 24.37975  6.21370   -6.18408  1.000 14.16359 ? 229  LYS A CG  1 
ATOM   1612 C CD  . LYS A 1 148 ? 22.88655  6.44399   -6.32124  1.000 12.78082 ? 229  LYS A CD  1 
ATOM   1613 C CE  . LYS A 1 148 ? 22.07336  5.44972   -5.50497  1.000 14.79482 ? 229  LYS A CE  1 
ATOM   1614 N NZ  . LYS A 1 148 ? 20.61631  5.74223   -5.58275  1.000 15.54838 ? 229  LYS A NZ  1 
ATOM   1615 N N   . CYS A 1 149 ? 27.58796  5.49249   -8.40980  1.000 9.66711  ? 230  CYS A N   1 
ATOM   1616 C CA  . CYS A 1 149 ? 28.15697  4.20594   -8.79787  1.000 9.17654  ? 230  CYS A CA  1 
ATOM   1617 C C   . CYS A 1 149 ? 29.56643  4.01538   -8.24558  1.000 9.36974  ? 230  CYS A C   1 
ATOM   1618 O O   . CYS A 1 149 ? 29.90385  2.93000   -7.75391  1.000 9.69233  ? 230  CYS A O   1 
ATOM   1619 C CB  . CYS A 1 149 ? 28.15803  4.05380   -10.31834 1.000 9.56884  ? 230  CYS A CB  1 
ATOM   1620 S SG  . CYS A 1 149 ? 26.49148  4.01525   -11.05054 1.000 9.93367  ? 230  CYS A SG  1 
ATOM   1621 N N   . ALA A 1 150 ? 30.41544  5.04273   -8.35687  1.000 10.18064 ? 231  ALA A N   1 
ATOM   1622 C CA  . ALA A 1 150 ? 31.74781  4.95891   -7.76740  1.000 11.41811 ? 231  ALA A CA  1 
ATOM   1623 C C   . ALA A 1 150 ? 31.66459  4.62202   -6.28807  1.000 11.26429 ? 231  ALA A C   1 
ATOM   1624 O O   . ALA A 1 150 ? 32.41400  3.77469   -5.78702  1.000 11.28040 ? 231  ALA A O   1 
ATOM   1625 C CB  . ALA A 1 150 ? 32.48874  6.27831   -7.96223  1.000 12.18119 ? 231  ALA A CB  1 
ATOM   1626 N N   . ASN A 1 151 ? 30.75217  5.27417   -5.57589  1.000 11.05562 ? 232  ASN A N   1 
ATOM   1627 C CA  . ASN A 1 151 ? 30.62673  5.04148   -4.14855  1.000 11.64216 ? 232  ASN A CA  1 
ATOM   1628 C C   . ASN A 1 151 ? 29.98664  3.70167   -3.83435  1.000 9.97441  ? 232  ASN A C   1 
ATOM   1629 O O   . ASN A 1 151 ? 30.17141  3.19520   -2.72342  1.000 12.10047 ? 232  ASN A O   1 
ATOM   1630 C CB  . ASN A 1 151 ? 29.86224  6.18835   -3.48800  1.000 14.67845 ? 232  ASN A CB  1 
ATOM   1631 C CG  . ASN A 1 151 ? 30.63802  7.49077   -3.52226  1.000 20.08705 ? 232  ASN A CG  1 
ATOM   1632 O OD1 . ASN A 1 151 ? 31.86991  7.48409   -3.53957  1.000 20.51463 ? 232  ASN A OD1 1 
ATOM   1633 N ND2 . ASN A 1 151 ? 29.92487  8.61341   -3.52241  1.000 26.71416 ? 232  ASN A ND2 1 
ATOM   1634 N N   . ALA A 1 152 ? 29.25368  3.11309   -4.78160  1.000 9.69430  ? 233  ALA A N   1 
ATOM   1635 C CA  . ALA A 1 152 ? 28.62739  1.81223   -4.58619  1.000 9.85447  ? 233  ALA A CA  1 
ATOM   1636 C C   . ALA A 1 152 ? 29.51031  0.64175   -5.00185  1.000 9.29125  ? 233  ALA A C   1 
ATOM   1637 O O   . ALA A 1 152 ? 29.16285  -0.50423  -4.70023  1.000 9.08567  ? 233  ALA A O   1 
ATOM   1638 C CB  . ALA A 1 152 ? 27.30025  1.73910   -5.35266  1.000 10.38118 ? 233  ALA A CB  1 
ATOM   1639 N N   . LYS A 1 153 ? 30.63677  0.90096   -5.66628  1.000 9.11720  ? 234  LYS A N   1 
ATOM   1640 C CA  . LYS A 1 153 ? 31.40515  -0.16156  -6.30825  1.000 9.01221  ? 234  LYS A CA  1 
ATOM   1641 C C   . LYS A 1 153 ? 31.76186  -1.28610  -5.34080  1.000 8.97763  ? 234  LYS A C   1 
ATOM   1642 O O   . LYS A 1 153 ? 31.51379  -2.46464  -5.62535  1.000 9.09318  ? 234  LYS A O   1 
ATOM   1643 C CB  . LYS A 1 153 ? 32.66384  0.41149   -6.95789  1.000 10.39448 ? 234  LYS A CB  1 
ATOM   1644 C CG  . LYS A 1 153 ? 33.58978  -0.64845  -7.54391  1.000 11.02350 ? 234  LYS A CG  1 
ATOM   1645 C CD  . LYS A 1 153 ? 34.72914  -0.03926  -8.31917  1.000 13.90048 ? 234  LYS A CD  1 
ATOM   1646 C CE  . LYS A 1 153 ? 35.76101  -1.09974  -8.67970  1.000 16.57637 ? 234  LYS A CE  1 
ATOM   1647 N NZ  . LYS A 1 153 ? 36.57338  -0.73095  -9.87629  1.000 22.86153 ? 234  LYS A NZ  1 
ATOM   1648 N N   . THR A 1 154 ? 32.36781  -0.95887  -4.20001  1.000 9.66170  ? 235  THR A N   1 
ATOM   1649 C CA  . THR A 1 154 ? 32.78158  -2.03907  -3.31090  1.000 10.12958 ? 235  THR A CA  1 
ATOM   1650 C C   . THR A 1 154 ? 31.58350  -2.80020  -2.75620  1.000 8.69801  ? 235  THR A C   1 
ATOM   1651 O O   . THR A 1 154 ? 31.67328  -4.01725  -2.56235  1.000 9.31024  ? 235  THR A O   1 
ATOM   1652 C CB  . THR A 1 154 ? 33.67560  -1.53291  -2.17908  1.000 11.84212 ? 235  THR A CB  1 
ATOM   1653 O OG1 . THR A 1 154 ? 32.96952  -0.54402  -1.43043  1.000 12.78568 ? 235  THR A OG1 1 
ATOM   1654 C CG2 . THR A 1 154 ? 34.97760  -0.95556  -2.72139  1.000 14.80678 ? 235  THR A CG2 1 
ATOM   1655 N N   . THR A 1 155 ? 30.45477  -2.11843  -2.52396  1.000 9.15699  ? 236  THR A N   1 
ATOM   1656 C CA  . THR A 1 155 ? 29.26852  -2.80571  -2.02046  1.000 8.99602  ? 236  THR A CA  1 
ATOM   1657 C C   . THR A 1 155 ? 28.66041  -3.71122  -3.08478  1.000 8.10057  ? 236  THR A C   1 
ATOM   1658 O O   . THR A 1 155 ? 28.26887  -4.85146  -2.79065  1.000 8.27500  ? 236  THR A O   1 
ATOM   1659 C CB  . THR A 1 155 ? 28.22396  -1.80475  -1.52924  1.000 9.37483  ? 236  THR A CB  1 
ATOM   1660 O OG1 . THR A 1 155 ? 28.78062  -0.97025  -0.50805  1.000 10.24770 ? 236  THR A OG1 1 
ATOM   1661 C CG2 . THR A 1 155 ? 27.01813  -2.54219  -0.96175  1.000 10.84677 ? 236  THR A CG2 1 
ATOM   1662 N N   . TYR A 1 156 ? 28.55244  -3.22743  -4.32435  1.000 8.21391  ? 237  TYR A N   1 
ATOM   1663 C CA  . TYR A 1 156 ? 28.03665  -4.07357  -5.39140  1.000 8.39737  ? 237  TYR A CA  1 
ATOM   1664 C C   . TYR A 1 156 ? 28.88322  -5.33529  -5.53242  1.000 8.17259  ? 237  TYR A C   1 
ATOM   1665 O O   . TYR A 1 156 ? 28.35546  -6.44672  -5.63681  1.000 7.84100  ? 237  TYR A O   1 
ATOM   1666 C CB  . TYR A 1 156 ? 28.04895  -3.30666  -6.70844  1.000 8.49152  ? 237  TYR A CB  1 
ATOM   1667 C CG  . TYR A 1 156 ? 26.89849  -2.35834  -6.97637  1.000 8.04067  ? 237  TYR A CG  1 
ATOM   1668 C CD1 . TYR A 1 156 ? 26.04060  -1.92132  -5.97359  1.000 9.09960  ? 237  TYR A CD1 1 
ATOM   1669 C CD2 . TYR A 1 156 ? 26.70077  -1.88003  -8.26267  1.000 8.43921  ? 237  TYR A CD2 1 
ATOM   1670 C CE1 . TYR A 1 156 ? 24.99872  -1.03214  -6.26698  1.000 9.05061  ? 237  TYR A CE1 1 
ATOM   1671 C CE2 . TYR A 1 156 ? 25.68464  -1.00267  -8.55907  1.000 8.96530  ? 237  TYR A CE2 1 
ATOM   1672 C CZ  . TYR A 1 156 ? 24.83453  -0.57859  -7.56340  1.000 8.32310  ? 237  TYR A CZ  1 
ATOM   1673 O OH  . TYR A 1 156 ? 23.83194  0.30217   -7.89930  1.000 9.11329  ? 237  TYR A OH  1 
ATOM   1674 N N   . LEU A 1 157 ? 30.20591  -5.17949  -5.53373  1.000 8.06219  ? 238  LEU A N   1 
ATOM   1675 C CA  . LEU A 1 157 ? 31.07155  -6.34005  -5.70491  1.000 8.54107  ? 238  LEU A CA  1 
ATOM   1676 C C   . LEU A 1 157 ? 30.93317  -7.30324  -4.53514  1.000 7.91708  ? 238  LEU A C   1 
ATOM   1677 O O   . LEU A 1 157 ? 30.84629  -8.52173  -4.73412  1.000 8.01072  ? 238  LEU A O   1 
ATOM   1678 C CB  . LEU A 1 157 ? 32.51488  -5.89603  -5.89682  1.000 8.95587  ? 238  LEU A CB  1 
ATOM   1679 C CG  . LEU A 1 157 ? 32.80004  -5.15341  -7.20039  1.000 10.42981 ? 238  LEU A CG  1 
ATOM   1680 C CD1 . LEU A 1 157 ? 34.18956  -4.54220  -7.16996  1.000 11.86620 ? 238  LEU A CD1 1 
ATOM   1681 C CD2 . LEU A 1 157 ? 32.64201  -6.07916  -8.40229  1.000 11.48980 ? 238  LEU A CD2 1 
ATOM   1682 N N   . ALA A 1 158 ? 30.91132  -6.78032  -3.30647  1.000 7.76645  ? 239  ALA A N   1 
ATOM   1683 C CA  . ALA A 1 158 ? 30.82612  -7.65682  -2.14175  1.000 8.21973  ? 239  ALA A CA  1 
ATOM   1684 C C   . ALA A 1 158 ? 29.47694  -8.34877  -2.07335  1.000 7.05696  ? 239  ALA A C   1 
ATOM   1685 O O   . ALA A 1 158 ? 29.38496  -9.52662  -1.70067  1.000 7.88691  ? 239  ALA A O   1 
ATOM   1686 C CB  . ALA A 1 158 ? 31.03839  -6.84601  -0.86692  1.000 9.18789  ? 239  ALA A CB  1 
ATOM   1687 N N   . SER A 1 159 ? 28.41625  -7.62139  -2.40964  1.000 7.33967  ? 240  SER A N   1 
ATOM   1688 C CA  . SER A 1 159 ? 27.07704  -8.17714  -2.30392  1.000 7.69203  ? 240  SER A CA  1 
ATOM   1689 C C   . SER A 1 159 ? 26.81610  -9.20359  -3.40173  1.000 6.94475  ? 240  SER A C   1 
ATOM   1690 O O   . SER A 1 159 ? 26.29233  -10.28711 -3.12760  1.000 7.31964  ? 240  SER A O   1 
ATOM   1691 C CB  . SER A 1 159 ? 26.05212  -7.05110  -2.32254  1.000 7.81189  ? 240  SER A CB  1 
ATOM   1692 O OG  . SER A 1 159 ? 26.08696  -6.28847  -1.13031  1.000 10.38920 ? 240  SER A OG  1 
ATOM   1693 N N   . VAL A 1 160 ? 27.19703  -8.89226  -4.63981  1.000 7.03174  ? 241  VAL A N   1 
ATOM   1694 C CA  . VAL A 1 160 ? 27.10172  -9.89004  -5.70008  1.000 6.98868  ? 241  VAL A CA  1 
ATOM   1695 C C   . VAL A 1 160 ? 27.93112  -11.11919 -5.34497  1.000 7.11101  ? 241  VAL A C   1 
ATOM   1696 O O   . VAL A 1 160 ? 27.48685  -12.25382 -5.53212  1.000 6.98309  ? 241  VAL A O   1 
ATOM   1697 C CB  . VAL A 1 160 ? 27.49063  -9.28583  -7.06323  1.000 7.29386  ? 241  VAL A CB  1 
ATOM   1698 C CG1 . VAL A 1 160 ? 27.68200  -10.38968 -8.10333  1.000 8.91658  ? 241  VAL A CG1 1 
ATOM   1699 C CG2 . VAL A 1 160 ? 26.43502  -8.28734  -7.51545  1.000 8.34438  ? 241  VAL A CG2 1 
ATOM   1700 N N   . ASN A 1 161 ? 29.13675  -10.92133 -4.81333  1.000 7.17250  ? 242  ASN A N   1 
ATOM   1701 C CA  . ASN A 1 161 ? 29.94259  -12.06527 -4.40364  1.000 7.34755  ? 242  ASN A CA  1 
ATOM   1702 C C   . ASN A 1 161 ? 29.22510  -12.91955 -3.36901  1.000 6.86514  ? 242  ASN A C   1 
ATOM   1703 O O   . ASN A 1 161 ? 29.26805  -14.15333 -3.43109  1.000 7.13603  ? 242  ASN A O   1 
ATOM   1704 C CB  . ASN A 1 161 ? 31.27313  -11.59828 -3.83082  1.000 7.65112  ? 242  ASN A CB  1 
ATOM   1705 C CG  . ASN A 1 161 ? 32.12780  -12.76001 -3.42568  1.000 7.30073  ? 242  ASN A CG  1 
ATOM   1706 O OD1 . ASN A 1 161 ? 32.61105  -13.50194 -4.28389  1.000 8.39560  ? 242  ASN A OD1 1 
ATOM   1707 N ND2 . ASN A 1 161 ? 32.27248  -12.96812 -2.13131  1.000 8.61185  ? 242  ASN A ND2 1 
ATOM   1708 N N   . TYR A 1 162 ? 28.58798  -12.28154 -2.39067  1.000 7.17804  ? 243  TYR A N   1 
ATOM   1709 C CA  . TYR A 1 162 ? 27.88411  -13.02711 -1.35543  1.000 6.95510  ? 243  TYR A CA  1 
ATOM   1710 C C   . TYR A 1 162 ? 26.74152  -13.84304 -1.95219  1.000 6.89994  ? 243  TYR A C   1 
ATOM   1711 O O   . TYR A 1 162 ? 26.52977  -15.00688 -1.57850  1.000 7.34074  ? 243  TYR A O   1 
ATOM   1712 C CB  . TYR A 1 162 ? 27.35816  -12.06119 -0.29297  1.000 7.33189  ? 243  TYR A CB  1 
ATOM   1713 C CG  . TYR A 1 162 ? 26.82960  -12.76909 0.93794   1.000 7.76981  ? 243  TYR A CG  1 
ATOM   1714 C CD1 . TYR A 1 162 ? 25.49988  -13.17960 1.01778   1.000 7.67090  ? 243  TYR A CD1 1 
ATOM   1715 C CD2 . TYR A 1 162 ? 27.65909  -13.03677 2.01132   1.000 7.68426  ? 243  TYR A CD2 1 
ATOM   1716 C CE1 . TYR A 1 162 ? 25.01597  -13.84499 2.13639   1.000 8.07280  ? 243  TYR A CE1 1 
ATOM   1717 C CE2 . TYR A 1 162 ? 27.18394  -13.69617 3.13998   1.000 9.04324  ? 243  TYR A CE2 1 
ATOM   1718 C CZ  . TYR A 1 162 ? 25.86196  -14.08928 3.19746   1.000 8.24613  ? 243  TYR A CZ  1 
ATOM   1719 O OH  . TYR A 1 162 ? 25.43062  -14.73467 4.32585   1.000 10.41558 ? 243  TYR A OH  1 
ATOM   1720 N N   . ALA A 1 163 ? 25.99797  -13.23892 -2.87821  1.000 6.81668  ? 244  ALA A N   1 
ATOM   1721 C CA  . ALA A 1 163 ? 24.92108  -13.93684 -3.55914  1.000 6.99512  ? 244  ALA A CA  1 
ATOM   1722 C C   . ALA A 1 163 ? 25.44233  -15.14595 -4.32122  1.000 6.89349  ? 244  ALA A C   1 
ATOM   1723 O O   . ALA A 1 163 ? 24.89564  -16.24630 -4.20128  1.000 6.91002  ? 244  ALA A O   1 
ATOM   1724 C CB  . ALA A 1 163 ? 24.20207  -12.97845 -4.50453  1.000 7.17530  ? 244  ALA A CB  1 
ATOM   1725 N N   . LEU A 1 164 ? 26.47769  -14.95340 -5.13672  1.000 6.75402  ? 245  LEU A N   1 
ATOM   1726 C CA  . LEU A 1 164 ? 27.00537  -16.05899 -5.93222  1.000 6.82307  ? 245  LEU A CA  1 
ATOM   1727 C C   . LEU A 1 164 ? 27.50633  -17.18102 -5.03691  1.000 6.81426  ? 245  LEU A C   1 
ATOM   1728 O O   . LEU A 1 164 ? 27.20870  -18.35852 -5.26303  1.000 7.89408  ? 245  LEU A O   1 
ATOM   1729 C CB  . LEU A 1 164 ? 28.14993  -15.55606 -6.80671  1.000 6.85774  ? 245  LEU A CB  1 
ATOM   1730 C CG  . LEU A 1 164 ? 27.78977  -14.58247 -7.91990  1.000 6.97576  ? 245  LEU A CG  1 
ATOM   1731 C CD1 . LEU A 1 164 ? 29.05976  -13.96991 -8.46628  1.000 8.76834  ? 245  LEU A CD1 1 
ATOM   1732 C CD2 . LEU A 1 164 ? 27.00249  -15.26331 -9.01770  1.000 8.48253  ? 245  LEU A CD2 1 
ATOM   1733 N N   A THR A 1 165 ? 28.27421  -16.80705 -4.00646  0.780 7.04622  ? 246  THR A N   1 
ATOM   1734 N N   B THR A 1 165 ? 28.29926  -16.85994 -4.02324  0.220 7.08394  ? 246  THR A N   1 
ATOM   1735 C CA  A THR A 1 165 ? 28.92474  -17.77280 -3.13098  0.780 7.85579  ? 246  THR A CA  1 
ATOM   1736 C CA  B THR A 1 165 ? 28.85954  -17.94626 -3.22590  0.220 7.82748  ? 246  THR A CA  1 
ATOM   1737 C C   A THR A 1 165 ? 27.89740  -18.59746 -2.36760  0.780 7.47971  ? 246  THR A C   1 
ATOM   1738 C C   B THR A 1 165 ? 27.76647  -18.68918 -2.46982  0.220 7.09124  ? 246  THR A C   1 
ATOM   1739 O O   A THR A 1 165 ? 28.06184  -19.81497 -2.21487  0.780 8.60764  ? 246  THR A O   1 
ATOM   1740 O O   B THR A 1 165 ? 27.73743  -19.92769 -2.44377  0.220 6.13208  ? 246  THR A O   1 
ATOM   1741 C CB  A THR A 1 165 ? 29.86009  -17.03858 -2.15271  0.780 7.81338  ? 246  THR A CB  1 
ATOM   1742 C CB  B THR A 1 165 ? 29.91242  -17.40305 -2.26551  0.220 9.03234  ? 246  THR A CB  1 
ATOM   1743 O OG1 A THR A 1 165 ? 30.94861  -16.44730 -2.86757  0.780 8.43123  ? 246  THR A OG1 1 
ATOM   1744 O OG1 B THR A 1 165 ? 29.33965  -16.35884 -1.47276  0.220 8.72036  ? 246  THR A OG1 1 
ATOM   1745 C CG2 A THR A 1 165 ? 30.43205  -17.98716 -1.11117  0.780 8.66645  ? 246  THR A CG2 1 
ATOM   1746 C CG2 B THR A 1 165 ? 31.07027  -16.83791 -3.05140  0.220 8.91510  ? 246  THR A CG2 1 
ATOM   1747 N N   . ASN A 1 166 ? 26.83833  -17.95573 -1.87526  1.000 7.33844  ? 247  ASN A N   1 
ATOM   1748 C CA  . ASN A 1 166 ? 25.86415  -18.64087 -1.04577  1.000 7.87730  ? 247  ASN A CA  1 
ATOM   1749 C C   . ASN A 1 166 ? 24.77909  -19.35059 -1.84171  1.000 7.22141  ? 247  ASN A C   1 
ATOM   1750 O O   . ASN A 1 166 ? 24.34455  -20.43645 -1.44324  1.000 8.46620  ? 247  ASN A O   1 
ATOM   1751 C CB  . ASN A 1 166 ? 25.37163  -17.71831 0.05573   1.000 8.42514  ? 247  ASN A CB  1 
ATOM   1752 C CG  . ASN A 1 166 ? 26.42516  -17.57060 1.11809   1.000 8.81569  ? 247  ASN A CG  1 
ATOM   1753 O OD1 . ASN A 1 166 ? 26.64889  -18.49923 1.89605   1.000 11.12961 ? 247  ASN A OD1 1 
ATOM   1754 N ND2 . ASN A 1 166 ? 27.14961  -16.46318 1.10140   1.000 9.19301  ? 247  ASN A ND2 1 
ATOM   1755 N N   . LEU A 1 167 ? 24.34240  -18.78492 -2.96999  1.000 6.96271  ? 248  LEU A N   1 
ATOM   1756 C CA  . LEU A 1 167 ? 23.39395  -19.51538 -3.80030  1.000 7.31250  ? 248  LEU A CA  1 
ATOM   1757 C C   . LEU A 1 167 ? 24.03456  -20.75420 -4.41931  1.000 7.38416  ? 248  LEU A C   1 
ATOM   1758 O O   . LEU A 1 167 ? 23.34617  -21.75952 -4.64293  1.000 7.52831  ? 248  LEU A O   1 
ATOM   1759 C CB  . LEU A 1 167 ? 22.79751  -18.59515 -4.86080  1.000 6.87442  ? 248  LEU A CB  1 
ATOM   1760 C CG  . LEU A 1 167 ? 21.89727  -17.48427 -4.32227  1.000 7.50902  ? 248  LEU A CG  1 
ATOM   1761 C CD1 . LEU A 1 167 ? 21.65341  -16.43928 -5.39827  1.000 8.68195  ? 248  LEU A CD1 1 
ATOM   1762 C CD2 . LEU A 1 167 ? 20.57974  -18.03340 -3.82086  1.000 10.10273 ? 248  LEU A CD2 1 
ATOM   1763 N N   . ALA A 1 168 ? 25.35002  -20.72043 -4.67491  1.000 7.20300  ? 249  ALA A N   1 
ATOM   1764 C CA  . ALA A 1 168 ? 26.01538  -21.91604 -5.18278  1.000 7.73121  ? 249  ALA A CA  1 
ATOM   1765 C C   . ALA A 1 168 ? 25.92618  -23.07487 -4.19581  1.000 7.26696  ? 249  ALA A C   1 
ATOM   1766 O O   . ALA A 1 168 ? 25.87189  -24.23705 -4.61405  1.000 8.13266  ? 249  ALA A O   1 
ATOM   1767 C CB  . ALA A 1 168 ? 27.48077  -21.62860 -5.49301  1.000 8.36191  ? 249  ALA A CB  1 
ATOM   1768 N N   . LYS A 1 169 ? 25.90949  -22.78268 -2.89067  1.000 7.65169  ? 250  LYS A N   1 
ATOM   1769 C CA  . LYS A 1 169 ? 25.86659  -23.82911 -1.87128  1.000 8.30874  ? 250  LYS A CA  1 
ATOM   1770 C C   . LYS A 1 169 ? 24.57248  -24.63015 -1.91056  1.000 8.13159  ? 250  LYS A C   1 
ATOM   1771 O O   . LYS A 1 169 ? 24.53665  -25.75705 -1.39821  1.000 9.88921  ? 250  LYS A O   1 
ATOM   1772 C CB  . LYS A 1 169 ? 26.03525  -23.22499 -0.47774  1.000 9.32783  ? 250  LYS A CB  1 
ATOM   1773 C CG  . LYS A 1 169 ? 27.40342  -22.60858 -0.23906  1.000 9.49133  ? 250  LYS A CG  1 
ATOM   1774 C CD  . LYS A 1 169 ? 27.46734  -21.91604 1.10612   1.000 10.38681 ? 250  LYS A CD  1 
ATOM   1775 C CE  . LYS A 1 169 ? 28.78706  -21.17932 1.29157   1.000 11.77838 ? 250  LYS A CE  1 
ATOM   1776 N NZ  . LYS A 1 169 ? 28.74590  -20.31460 2.50492   1.000 13.13241 ? 250  LYS A NZ  1 
ATOM   1777 N N   . VAL A 1 170 ? 23.51243  -24.06711 -2.48475  1.000 8.02403  ? 251  VAL A N   1 
ATOM   1778 C CA  . VAL A 1 170 ? 22.25186  -24.77089 -2.66457  1.000 8.46304  ? 251  VAL A CA  1 
ATOM   1779 C C   . VAL A 1 170 ? 22.00296  -25.10704 -4.13284  1.000 8.51987  ? 251  VAL A C   1 
ATOM   1780 O O   . VAL A 1 170 ? 20.87423  -25.41706 -4.52008  1.000 9.66551  ? 251  VAL A O   1 
ATOM   1781 C CB  . VAL A 1 170 ? 21.06568  -24.06488 -1.98461  1.000 9.84301  ? 251  VAL A CB  1 
ATOM   1782 C CG1 . VAL A 1 170 ? 21.16244  -24.26202 -0.50122  1.000 11.53744 ? 251  VAL A CG1 1 
ATOM   1783 C CG2 . VAL A 1 170 ? 21.01450  -22.58200 -2.32955  1.000 9.28533  ? 251  VAL A CG2 1 
ATOM   1784 N N   . GLY A 1 171 ? 23.05134  -25.07398 -4.95453  1.000 7.99644  ? 252  GLY A N   1 
ATOM   1785 C CA  . GLY A 1 171 ? 22.97110  -25.62863 -6.28908  1.000 8.04432  ? 252  GLY A CA  1 
ATOM   1786 C C   . GLY A 1 171 ? 22.17594  -24.82144 -7.28533  1.000 6.94480  ? 252  GLY A C   1 
ATOM   1787 O O   . GLY A 1 171 ? 21.71562  -25.37664 -8.28866  1.000 7.76058  ? 252  GLY A O   1 
ATOM   1788 N N   . VAL A 1 172 ? 22.03485  -23.51138 -7.05823  1.000 7.08212  ? 253  VAL A N   1 
ATOM   1789 C CA  . VAL A 1 172 ? 21.32694  -22.62825 -7.98185  1.000 7.04038  ? 253  VAL A CA  1 
ATOM   1790 C C   . VAL A 1 172 ? 22.19138  -22.36166 -9.20656  1.000 6.59522  ? 253  VAL A C   1 
ATOM   1791 O O   . VAL A 1 172 ? 23.36054  -21.98818 -9.07791  1.000 7.05637  ? 253  VAL A O   1 
ATOM   1792 C CB  . VAL A 1 172 ? 20.99953  -21.30896 -7.26860  1.000 6.94416  ? 253  VAL A CB  1 
ATOM   1793 C CG1 . VAL A 1 172 ? 20.34642  -20.32478 -8.22114  1.000 7.48508  ? 253  VAL A CG1 1 
ATOM   1794 C CG2 . VAL A 1 172 ? 20.10903  -21.55872 -6.06564  1.000 8.04244  ? 253  VAL A CG2 1 
ATOM   1795 N N   . TYR A 1 173 ? 21.60924  -22.51928 -10.39708 1.000 6.37647  ? 254  TYR A N   1 
ATOM   1796 C CA  . TYR A 1 173 ? 22.29395  -22.16962 -11.63495 1.000 6.56413  ? 254  TYR A CA  1 
ATOM   1797 C C   . TYR A 1 173 ? 22.15016  -20.67403 -11.87687 1.000 6.35174  ? 254  TYR A C   1 
ATOM   1798 O O   . TYR A 1 173 ? 21.03569  -20.14563 -11.87272 1.000 7.83506  ? 254  TYR A O   1 
ATOM   1799 C CB  . TYR A 1 173 ? 21.71115  -22.97757 -12.79601 1.000 7.25742  ? 254  TYR A CB  1 
ATOM   1800 C CG  . TYR A 1 173 ? 22.14824  -24.41963 -12.73049 1.000 6.78450  ? 254  TYR A CG  1 
ATOM   1801 C CD1 . TYR A 1 173 ? 23.38790  -24.79595 -13.22483 1.000 7.93927  ? 254  TYR A CD1 1 
ATOM   1802 C CD2 . TYR A 1 173 ? 21.36947  -25.39669 -12.11469 1.000 7.79961  ? 254  TYR A CD2 1 
ATOM   1803 C CE1 . TYR A 1 173 ? 23.83016  -26.10774 -13.14977 1.000 9.06892  ? 254  TYR A CE1 1 
ATOM   1804 C CE2 . TYR A 1 173 ? 21.81085  -26.71882 -12.03002 1.000 8.45724  ? 254  TYR A CE2 1 
ATOM   1805 C CZ  . TYR A 1 173 ? 23.04429  -27.06342 -12.54824 1.000 8.17257  ? 254  TYR A CZ  1 
ATOM   1806 O OH  . TYR A 1 173 ? 23.52712  -28.34851 -12.49971 1.000 10.20483 ? 254  TYR A OH  1 
ATOM   1807 N N   A MET A 1 174 ? 23.27590  -19.99675 -12.07443 0.747 6.38109  ? 255  MET A N   1 
ATOM   1808 N N   B MET A 1 174 ? 23.26982  -19.99071 -12.11527 0.253 6.43444  ? 255  MET A N   1 
ATOM   1809 C CA  A MET A 1 174 ? 23.30620  -18.54283 -12.05493 0.747 6.78293  ? 255  MET A CA  1 
ATOM   1810 C CA  B MET A 1 174 ? 23.29682  -18.53475 -12.03961 0.253 6.76463  ? 255  MET A CA  1 
ATOM   1811 C C   A MET A 1 174 ? 23.86103  -17.95526 -13.34328 0.747 6.41276  ? 255  MET A C   1 
ATOM   1812 C C   B MET A 1 174 ? 23.91959  -17.88165 -13.26164 0.253 6.51901  ? 255  MET A C   1 
ATOM   1813 O O   A MET A 1 174 ? 24.85619  -18.44260 -13.90154 0.747 6.67755  ? 255  MET A O   1 
ATOM   1814 O O   B MET A 1 174 ? 25.02096  -18.25064 -13.68912 0.253 5.40848  ? 255  MET A O   1 
ATOM   1815 C CB  A MET A 1 174 ? 24.13392  -18.04589 -10.87063 0.747 6.73694  ? 255  MET A CB  1 
ATOM   1816 C CB  B MET A 1 174 ? 24.03317  -18.08602 -10.78458 0.253 7.06840  ? 255  MET A CB  1 
ATOM   1817 C CG  A MET A 1 174 ? 23.53515  -18.43129 -9.52533  0.747 7.27933  ? 255  MET A CG  1 
ATOM   1818 C CG  B MET A 1 174 ? 23.35124  -18.55685 -9.53864  0.253 7.27181  ? 255  MET A CG  1 
ATOM   1819 S SD  A MET A 1 174 ? 24.62805  -18.14638 -8.10280  0.747 7.29148  ? 255  MET A SD  1 
ATOM   1820 S SD  B MET A 1 174 ? 24.20130  -17.95432 -8.09319  0.253 6.26800  ? 255  MET A SD  1 
ATOM   1821 C CE  A MET A 1 174 ? 25.65758  -19.60012 -8.19912  0.747 7.75334  ? 255  MET A CE  1 
ATOM   1822 C CE  B MET A 1 174 ? 25.52175  -19.15736 -7.98777  0.253 9.55615  ? 255  MET A CE  1 
ATOM   1823 N N   . TYR A 1 175 ? 23.23164  -16.86205 -13.76818 1.000 6.29592  ? 256  TYR A N   1 
ATOM   1824 C CA  . TYR A 1 175 ? 23.69410  -16.04341 -14.87672 1.000 6.49238  ? 256  TYR A CA  1 
ATOM   1825 C C   . TYR A 1 175 ? 23.77408  -14.61223 -14.35933 1.000 6.35611  ? 256  TYR A C   1 
ATOM   1826 O O   . TYR A 1 175 ? 22.76126  -14.04220 -13.93977 1.000 7.17166  ? 256  TYR A O   1 
ATOM   1827 C CB  . TYR A 1 175 ? 22.73379  -16.14517 -16.07087 1.000 6.85697  ? 256  TYR A CB  1 
ATOM   1828 C CG  . TYR A 1 175 ? 22.65348  -17.54760 -16.64942 1.000 6.50135  ? 256  TYR A CG  1 
ATOM   1829 C CD1 . TYR A 1 175 ? 21.77712  -18.48693 -16.12368 1.000 7.12286  ? 256  TYR A CD1 1 
ATOM   1830 C CD2 . TYR A 1 175 ? 23.45232  -17.92226 -17.71758 1.000 6.79164  ? 256  TYR A CD2 1 
ATOM   1831 C CE1 . TYR A 1 175 ? 21.70040  -19.76920 -16.64262 1.000 7.72228  ? 256  TYR A CE1 1 
ATOM   1832 C CE2 . TYR A 1 175 ? 23.38229  -19.21616 -18.24424 1.000 6.94457  ? 256  TYR A CE2 1 
ATOM   1833 C CZ  . TYR A 1 175 ? 22.50659  -20.13525 -17.69606 1.000 7.06888  ? 256  TYR A CZ  1 
ATOM   1834 O OH  . TYR A 1 175 ? 22.38744  -21.41817 -18.18820 1.000 8.37489  ? 256  TYR A OH  1 
ATOM   1835 N N   A MET A 1 176 ? 24.98999  -14.05629 -14.31837 0.576 6.84393  ? 257  MET A N   1 
ATOM   1836 N N   B MET A 1 176 ? 24.96083  -14.03259 -14.39116 0.424 6.93955  ? 257  MET A N   1 
ATOM   1837 C CA  A MET A 1 176 ? 25.15102  -12.66585 -13.89652 0.576 7.05952  ? 257  MET A CA  1 
ATOM   1838 C CA  B MET A 1 176 ? 25.12670  -12.68143 -13.88301 0.424 7.02891  ? 257  MET A CA  1 
ATOM   1839 C C   A MET A 1 176 ? 24.59632  -11.73532 -14.96883 0.576 6.64250  ? 257  MET A C   1 
ATOM   1840 C C   B MET A 1 176 ? 24.68415  -11.68778 -14.94779 0.424 6.73159  ? 257  MET A C   1 
ATOM   1841 O O   A MET A 1 176 ? 24.82377  -11.93866 -16.15938 0.576 6.39455  ? 257  MET A O   1 
ATOM   1842 O O   B MET A 1 176 ? 25.03863  -11.82902 -16.11665 0.424 5.70566  ? 257  MET A O   1 
ATOM   1843 C CB  A MET A 1 176 ? 26.62963  -12.27811 -13.70100 0.576 9.00657  ? 257  MET A CB  1 
ATOM   1844 C CB  B MET A 1 176 ? 26.60135  -12.44956 -13.59329 0.424 9.20074  ? 257  MET A CB  1 
ATOM   1845 C CG  A MET A 1 176 ? 27.57559  -13.23633 -12.98657 0.576 9.96986  ? 257  MET A CG  1 
ATOM   1846 C CG  B MET A 1 176 ? 27.02660  -12.96717 -12.26481 0.424 10.63392 ? 257  MET A CG  1 
ATOM   1847 S SD  A MET A 1 176 ? 29.28362  -12.55620 -12.99778 0.576 10.14818 ? 257  MET A SD  1 
ATOM   1848 S SD  B MET A 1 176 ? 28.73802  -12.55227 -12.02552 0.424 11.28908 ? 257  MET A SD  1 
ATOM   1849 C CE  A MET A 1 176 ? 30.17978  -13.95403 -12.32218 0.576 10.65068 ? 257  MET A CE  1 
ATOM   1850 C CE  B MET A 1 176 ? 29.52802  -13.80494 -13.02083 0.424 12.02622 ? 257  MET A CE  1 
ATOM   1851 N N   . ASP A 1 177 ? 23.91418  -10.67334 -14.55576 1.000 6.72802  ? 258  ASP A N   1 
ATOM   1852 C CA  . ASP A 1 177 ? 23.48749  -9.70371  -15.54848 1.000 6.88639  ? 258  ASP A CA  1 
ATOM   1853 C C   . ASP A 1 177 ? 24.69923  -9.04693  -16.20079 1.000 6.50570  ? 258  ASP A C   1 
ATOM   1854 O O   . ASP A 1 177 ? 25.65956  -8.66772  -15.52444 1.000 7.61434  ? 258  ASP A O   1 
ATOM   1855 C CB  . ASP A 1 177 ? 22.61030  -8.61767  -14.95448 1.000 6.98988  ? 258  ASP A CB  1 
ATOM   1856 C CG  . ASP A 1 177 ? 22.13298  -7.68135  -16.02431 1.000 7.00097  ? 258  ASP A CG  1 
ATOM   1857 O OD1 . ASP A 1 177 ? 21.13026  -8.04216  -16.67016 1.000 8.52833  ? 258  ASP A OD1 1 
ATOM   1858 O OD2 . ASP A 1 177 ? 22.79624  -6.63669  -16.26145 1.000 7.74355  ? 258  ASP A OD2 1 
ATOM   1859 N N   . ALA A 1 178 ? 24.62928  -8.87644  -17.51867 1.000 6.54291  ? 259  ALA A N   1 
ATOM   1860 C CA  . ALA A 1 178 ? 25.72103  -8.30830  -18.28920 1.000 6.89577  ? 259  ALA A CA  1 
ATOM   1861 C C   . ALA A 1 178 ? 25.21840  -7.26688  -19.27919 1.000 6.26783  ? 259  ALA A C   1 
ATOM   1862 O O   . ALA A 1 178 ? 25.75843  -7.12071  -20.37652 1.000 7.26171  ? 259  ALA A O   1 
ATOM   1863 C CB  . ALA A 1 178 ? 26.54633  -9.39105  -18.98129 1.000 7.80432  ? 259  ALA A CB  1 
ATOM   1864 N N   . GLY A 1 179 ? 24.21421  -6.47692  -18.90117 1.000 7.07826  ? 260  GLY A N   1 
ATOM   1865 C CA  . GLY A 1 179 ? 23.80473  -5.40922  -19.80692 1.000 7.34036  ? 260  GLY A CA  1 
ATOM   1866 C C   . GLY A 1 179 ? 23.34804  -5.95739  -21.14493 1.000 6.56461  ? 260  GLY A C   1 
ATOM   1867 O O   . GLY A 1 179 ? 22.69504  -7.00249  -21.21637 1.000 7.08643  ? 260  GLY A O   1 
ATOM   1868 N N   . HIS A 1 180 ? 23.65915  -5.22269  -22.21345 1.000 6.96548  ? 261  HIS A N   1 
ATOM   1869 C CA  . HIS A 1 180 ? 23.19251  -5.55219  -23.55331 1.000 7.13967  ? 261  HIS A CA  1 
ATOM   1870 C C   . HIS A 1 180 ? 24.19698  -5.00812  -24.55719 1.000 6.92706  ? 261  HIS A C   1 
ATOM   1871 O O   . HIS A 1 180 ? 25.17143  -4.34826  -24.19099 1.000 7.20943  ? 261  HIS A O   1 
ATOM   1872 C CB  . HIS A 1 180 ? 21.77446  -5.01216  -23.78578 1.000 7.68803  ? 261  HIS A CB  1 
ATOM   1873 C CG  . HIS A 1 180 ? 21.66899  -3.52275  -23.73837 1.000 7.91852  ? 261  HIS A CG  1 
ATOM   1874 N ND1 . HIS A 1 180 ? 21.83295  -2.72186  -24.84898 1.000 7.71481  ? 261  HIS A ND1 1 
ATOM   1875 C CD2 . HIS A 1 180 ? 21.40163  -2.69511  -22.70061 1.000 10.25223 ? 261  HIS A CD2 1 
ATOM   1876 C CE1 . HIS A 1 180 ? 21.66822  -1.46042  -24.48941 1.000 8.64895  ? 261  HIS A CE1 1 
ATOM   1877 N NE2 . HIS A 1 180 ? 21.40687  -1.41559  -23.19450 1.000 10.37243 ? 261  HIS A NE2 1 
ATOM   1878 N N   . ALA A 1 181 ? 23.94239  -5.27430  -25.83732 1.000 7.14291  ? 262  ALA A N   1 
ATOM   1879 C CA  . ALA A 1 181 ? 24.89964  -4.92850  -26.87927 1.000 7.18293  ? 262  ALA A CA  1 
ATOM   1880 C C   . ALA A 1 181 ? 25.22114  -3.44316  -26.91878 1.000 7.25673  ? 262  ALA A C   1 
ATOM   1881 O O   . ALA A 1 181 ? 26.34944  -3.06691  -27.26227 1.000 8.09702  ? 262  ALA A O   1 
ATOM   1882 C CB  . ALA A 1 181 ? 24.36878  -5.36444  -28.24160 1.000 8.19510  ? 262  ALA A CB  1 
ATOM   1883 N N   . GLY A 1 182 ? 24.24430  -2.58976  -26.60972 1.000 7.23729  ? 263  GLY A N   1 
ATOM   1884 C CA  . GLY A 1 182 ? 24.44838  -1.15937  -26.62387 1.000 8.08092  ? 263  GLY A CA  1 
ATOM   1885 C C   . GLY A 1 182 ? 25.02321  -0.58939  -25.36361 1.000 6.94671  ? 263  GLY A C   1 
ATOM   1886 O O   . GLY A 1 182 ? 25.19398  0.63055   -25.25982 1.000 8.37309  ? 263  GLY A O   1 
ATOM   1887 N N   . TRP A 1 183 ? 25.32136  -1.45640  -24.40046 1.000 7.28104  ? 264  TRP A N   1 
ATOM   1888 C CA  . TRP A 1 183 ? 25.94145  -1.05512  -23.14791 1.000 7.72492  ? 264  TRP A CA  1 
ATOM   1889 C C   . TRP A 1 183 ? 27.36110  -1.60768  -23.10467 1.000 7.06069  ? 264  TRP A C   1 
ATOM   1890 O O   . TRP A 1 183 ? 28.31995  -0.85426  -23.29152 1.000 8.51666  ? 264  TRP A O   1 
ATOM   1891 C CB  . TRP A 1 183 ? 25.09395  -1.51702  -21.96021 1.000 7.94258  ? 264  TRP A CB  1 
ATOM   1892 C CG  . TRP A 1 183 ? 25.50093  -0.90929  -20.65196 1.000 7.58757  ? 264  TRP A CG  1 
ATOM   1893 C CD1 . TRP A 1 183 ? 26.62505  -0.17437  -20.40488 1.000 9.16242  ? 264  TRP A CD1 1 
ATOM   1894 C CD2 . TRP A 1 183 ? 24.78103  -0.95636  -19.41946 1.000 8.60017  ? 264  TRP A CD2 1 
ATOM   1895 N NE1 . TRP A 1 183 ? 26.65737  0.23122   -19.09438 1.000 9.76250  ? 264  TRP A NE1 1 
ATOM   1896 C CE2 . TRP A 1 183 ? 25.53371  -0.23349  -18.46768 1.000 9.32758  ? 264  TRP A CE2 1 
ATOM   1897 C CE3 . TRP A 1 183 ? 23.58606  -1.54716  -19.02094 1.000 9.40688  ? 264  TRP A CE3 1 
ATOM   1898 C CZ2 . TRP A 1 183 ? 25.11523  -0.06704  -17.15494 1.000 10.29386 ? 264  TRP A CZ2 1 
ATOM   1899 C CZ3 . TRP A 1 183 ? 23.17937  -1.38568  -17.70716 1.000 10.84905 ? 264  TRP A CZ3 1 
ATOM   1900 C CH2 . TRP A 1 183 ? 23.94469  -0.65906  -16.79014 1.000 11.60684 ? 264  TRP A CH2 1 
ATOM   1901 N N   . LEU A 1 184 ? 27.51203  -2.92134  -22.92969 1.000 7.20949  ? 265  LEU A N   1 
ATOM   1902 C CA  . LEU A 1 184 ? 28.81884  -3.55441  -22.84223 1.000 7.56850  ? 265  LEU A CA  1 
ATOM   1903 C C   . LEU A 1 184 ? 29.30612  -4.14309  -24.16372 1.000 7.72669  ? 265  LEU A C   1 
ATOM   1904 O O   . LEU A 1 184 ? 30.46942  -4.55812  -24.24825 1.000 8.66671  ? 265  LEU A O   1 
ATOM   1905 C CB  . LEU A 1 184 ? 28.82043  -4.62626  -21.74225 1.000 7.69358  ? 265  LEU A CB  1 
ATOM   1906 C CG  . LEU A 1 184 ? 28.40972  -4.13993  -20.34797 1.000 8.11185  ? 265  LEU A CG  1 
ATOM   1907 C CD1 . LEU A 1 184 ? 28.54727  -5.27747  -19.34972 1.000 8.13802  ? 265  LEU A CD1 1 
ATOM   1908 C CD2 . LEU A 1 184 ? 29.21607  -2.91858  -19.90682 1.000 9.11110  ? 265  LEU A CD2 1 
ATOM   1909 N N   . GLY A 1 185 ? 28.46205  -4.16575  -25.19699 1.000 7.73543  ? 266  GLY A N   1 
ATOM   1910 C CA  . GLY A 1 185 ? 28.83356  -4.75685  -26.46728 1.000 8.09300  ? 266  GLY A CA  1 
ATOM   1911 C C   . GLY A 1 185 ? 29.62721  -3.86391  -27.38918 1.000 7.90589  ? 266  GLY A C   1 
ATOM   1912 O O   . GLY A 1 185 ? 30.19149  -4.36395  -28.36633 1.000 8.89309  ? 266  GLY A O   1 
ATOM   1913 N N   . TRP A 1 186 ? 29.66412  -2.55774  -27.13375 1.000 7.83844  ? 267  TRP A N   1 
ATOM   1914 C CA  . TRP A 1 186 ? 30.61285  -1.69965  -27.82398 1.000 8.16874  ? 267  TRP A CA  1 
ATOM   1915 C C   . TRP A 1 186 ? 31.98342  -2.36043  -27.77297 1.000 8.05794  ? 267  TRP A C   1 
ATOM   1916 O O   . TRP A 1 186 ? 32.41834  -2.76665  -26.68921 1.000 8.42047  ? 267  TRP A O   1 
ATOM   1917 C CB  . TRP A 1 186 ? 30.68898  -0.33916  -27.11034 1.000 8.23427  ? 267  TRP A CB  1 
ATOM   1918 C CG  . TRP A 1 186 ? 29.46373  0.48958   -27.36415 1.000 8.08215  ? 267  TRP A CG  1 
ATOM   1919 C CD1 . TRP A 1 186 ? 28.31637  0.53219   -26.61252 1.000 8.54444  ? 267  TRP A CD1 1 
ATOM   1920 C CD2 . TRP A 1 186 ? 29.23760  1.33996   -28.48429 1.000 7.65665  ? 267  TRP A CD2 1 
ATOM   1921 N NE1 . TRP A 1 186 ? 27.39397  1.35880   -27.20173 1.000 8.39059  ? 267  TRP A NE1 1 
ATOM   1922 C CE2 . TRP A 1 186 ? 27.93670  1.87837   -28.34761 1.000 8.19920  ? 267  TRP A CE2 1 
ATOM   1923 C CE3 . TRP A 1 186 ? 30.01516  1.72149   -29.57853 1.000 8.53588  ? 267  TRP A CE3 1 
ATOM   1924 C CZ2 . TRP A 1 186 ? 27.39397  2.76301   -29.28500 1.000 9.88169  ? 267  TRP A CZ2 1 
ATOM   1925 C CZ3 . TRP A 1 186 ? 29.48032  2.61284   -30.50032 1.000 9.77408  ? 267  TRP A CZ3 1 
ATOM   1926 C CH2 . TRP A 1 186 ? 28.18685  3.12164   -30.34796 1.000 10.05195 ? 267  TRP A CH2 1 
ATOM   1927 N N   . PRO A 1 187 ? 32.68357  -2.49656  -28.90056 1.000 8.35587  ? 268  PRO A N   1 
ATOM   1928 C CA  . PRO A 1 187 ? 33.97719  -3.19911  -28.86987 1.000 9.19083  ? 268  PRO A CA  1 
ATOM   1929 C C   . PRO A 1 187 ? 34.91051  -2.74372  -27.76003 1.000 8.39404  ? 268  PRO A C   1 
ATOM   1930 O O   . PRO A 1 187 ? 35.54353  -3.58484  -27.11067 1.000 9.87883  ? 268  PRO A O   1 
ATOM   1931 C CB  . PRO A 1 187 ? 34.52991  -2.94874  -30.27635 1.000 10.00895 ? 268  PRO A CB  1 
ATOM   1932 C CG  . PRO A 1 187 ? 33.29574  -2.94502  -31.12034 1.000 10.68285 ? 268  PRO A CG  1 
ATOM   1933 C CD  . PRO A 1 187 ? 32.22173  -2.27614  -30.28031 1.000 9.22806  ? 268  PRO A CD  1 
ATOM   1934 N N   . ALA A 1 188 ? 34.98248  -1.43728  -27.50335 1.000 8.18590  ? 269  ALA A N   1 
ATOM   1935 C CA  . ALA A 1 188 ? 35.89748  -0.93137  -26.48910 1.000 8.66122  ? 269  ALA A CA  1 
ATOM   1936 C C   . ALA A 1 188 ? 35.48652  -1.29305  -25.06585 1.000 8.31853  ? 269  ALA A C   1 
ATOM   1937 O O   . ALA A 1 188 ? 36.31769  -1.21333  -24.15765 1.000 9.78458  ? 269  ALA A O   1 
ATOM   1938 C CB  . ALA A 1 188 ? 36.01035  0.58297   -26.59841 1.000 10.61795 ? 269  ALA A CB  1 
ATOM   1939 N N   . ASN A 1 189 ? 34.23128  -1.65853  -24.83521 1.000 7.59973  ? 270  ASN A N   1 
ATOM   1940 C CA  . ASN A 1 189 ? 33.79143  -2.06278  -23.50974 1.000 7.70928  ? 270  ASN A CA  1 
ATOM   1941 C C   . ASN A 1 189 ? 33.92441  -3.55708  -23.26484 1.000 7.97838  ? 270  ASN A C   1 
ATOM   1942 O O   . ASN A 1 189 ? 33.80957  -3.98700  -22.10911 1.000 8.43592  ? 270  ASN A O   1 
ATOM   1943 C CB  . ASN A 1 189 ? 32.33425  -1.63938  -23.28400 1.000 8.26172  ? 270  ASN A CB  1 
ATOM   1944 C CG  . ASN A 1 189 ? 32.17050  -0.13954  -23.17599 1.000 7.58239  ? 270  ASN A CG  1 
ATOM   1945 O OD1 . ASN A 1 189 ? 33.12577  0.58895   -22.89822 1.000 9.13233  ? 270  ASN A OD1 1 
ATOM   1946 N ND2 . ASN A 1 189 ? 30.94770  0.33755   -23.39203 1.000 8.00650  ? 270  ASN A ND2 1 
ATOM   1947 N N   A LEU A 1 190 ? 34.23723  -4.35238  -24.28592 0.748 8.44289  ? 271  LEU A N   1 
ATOM   1948 N N   B LEU A 1 190 ? 34.10413  -4.34518  -24.34167 0.252 8.51314  ? 271  LEU A N   1 
ATOM   1949 C CA  A LEU A 1 190 ? 34.24212  -5.80452  -24.12225 0.748 8.27570  ? 271  LEU A CA  1 
ATOM   1950 C CA  B LEU A 1 190 ? 33.99814  -5.80477  -24.27815 0.252 8.00155  ? 271  LEU A CA  1 
ATOM   1951 C C   A LEU A 1 190 ? 35.30723  -6.25295  -23.13229 0.748 8.43190  ? 271  LEU A C   1 
ATOM   1952 C C   B LEU A 1 190 ? 35.08357  -6.40325  -23.39978 0.252 7.94636  ? 271  LEU A C   1 
ATOM   1953 O O   A LEU A 1 190 ? 35.04054  -7.06537  -22.23526 0.748 9.13371  ? 271  LEU A O   1 
ATOM   1954 O O   B LEU A 1 190 ? 34.79340  -7.19358  -22.49438 0.252 6.84861  ? 271  LEU A O   1 
ATOM   1955 C CB  A LEU A 1 190 ? 34.48232  -6.48040  -25.47025 0.748 8.75246  ? 271  LEU A CB  1 
ATOM   1956 C CB  B LEU A 1 190 ? 34.06816  -6.42961  -25.67939 0.252 7.91859  ? 271  LEU A CB  1 
ATOM   1957 C CG  A LEU A 1 190 ? 33.38068  -6.35650  -26.51643 0.748 8.80085  ? 271  LEU A CG  1 
ATOM   1958 C CG  B LEU A 1 190 ? 32.93704  -6.26285  -26.69222 0.252 10.52579 ? 271  LEU A CG  1 
ATOM   1959 C CD1 A LEU A 1 190 ? 33.90811  -6.82877  -27.86526 0.748 9.57443  ? 271  LEU A CD1 1 
ATOM   1960 C CD1 B LEU A 1 190 ? 33.40884  -6.66262  -28.08772 0.252 10.30704 ? 271  LEU A CD1 1 
ATOM   1961 C CD2 A LEU A 1 190 ? 32.13838  -7.12114  -26.10070 0.748 9.91101  ? 271  LEU A CD2 1 
ATOM   1962 C CD2 B LEU A 1 190 ? 31.72294  -7.07402  -26.28768 0.252 10.71317 ? 271  LEU A CD2 1 
ATOM   1963 N N   A SER A 1 191 ? 36.53410  -5.76741  -23.30928 0.748 8.47157  ? 272  SER A N   1 
ATOM   1964 N N   B SER A 1 191 ? 36.34590  -6.07528  -23.68125 0.252 8.08387  ? 272  SER A N   1 
ATOM   1965 C CA  A SER A 1 191 ? 37.62037  -6.22158  -22.44801 0.748 9.87070  ? 272  SER A CA  1 
ATOM   1966 C CA  B SER A 1 191 ? 37.43118  -6.53302  -22.81543 0.252 8.65475  ? 272  SER A CA  1 
ATOM   1967 C C   A SER A 1 191 ? 37.45505  -5.75646  -21.00701 0.748 8.55978  ? 272  SER A C   1 
ATOM   1968 C C   B SER A 1 191 ? 37.28104  -6.04466  -21.38087 0.252 7.41667  ? 272  SER A C   1 
ATOM   1969 O O   A SER A 1 191 ? 37.59946  -6.58547  -20.09299 0.748 9.38226  ? 272  SER A O   1 
ATOM   1970 O O   B SER A 1 191 ? 37.40274  -6.87033  -20.45871 0.252 9.03043  ? 272  SER A O   1 
ATOM   1971 C CB  A SER A 1 191 ? 38.96090  -5.84237  -23.06990 0.748 10.34831 ? 272  SER A CB  1 
ATOM   1972 C CB  B SER A 1 191 ? 38.79693  -6.18921  -23.42338 0.252 10.77190 ? 272  SER A CB  1 
ATOM   1973 O OG  A SER A 1 191 ? 40.00964  -6.26598  -22.24244 0.748 12.77904 ? 272  SER A OG  1 
ATOM   1974 O OG  B SER A 1 191 ? 39.26685  -7.22215  -24.26965 0.252 16.89667 ? 272  SER A OG  1 
ATOM   1975 N N   A PRO A 1 192 ? 37.16644  -4.48764  -20.71697 0.748 8.73015  ? 273  PRO A N   1 
ATOM   1976 N N   B PRO A 1 192 ? 37.02657  -4.75413  -21.11168 0.252 7.79298  ? 273  PRO A N   1 
ATOM   1977 C CA  A PRO A 1 192 ? 36.90699  -4.13586  -19.31415 0.748 9.48779  ? 273  PRO A CA  1 
ATOM   1978 C CA  B PRO A 1 192 ? 36.72226  -4.34776  -19.72671 0.252 8.85883  ? 273  PRO A CA  1 
ATOM   1979 C C   A PRO A 1 192 ? 35.75521  -4.92128  -18.71248 0.748 8.63035  ? 273  PRO A C   1 
ATOM   1980 C C   B PRO A 1 192 ? 35.63306  -5.18961  -19.07806 0.252 7.30620  ? 273  PRO A C   1 
ATOM   1981 O O   A PRO A 1 192 ? 35.81091  -5.28898  -17.53347 0.748 9.33541  ? 273  PRO A O   1 
ATOM   1982 O O   B PRO A 1 192 ? 35.75113  -5.56543  -17.90366 0.252 7.98800  ? 273  PRO A O   1 
ATOM   1983 C CB  A PRO A 1 192 ? 36.63716  -2.62979  -19.36968 0.748 11.16508 ? 273  PRO A CB  1 
ATOM   1984 C CB  B PRO A 1 192 ? 36.30219  -2.88069  -19.89012 0.252 11.09383 ? 273  PRO A CB  1 
ATOM   1985 C CG  A PRO A 1 192 ? 37.32863  -2.16744  -20.62034 0.748 14.57675 ? 273  PRO A CG  1 
ATOM   1986 C CG  B PRO A 1 192 ? 37.07648  -2.40857  -21.06026 0.252 13.70526 ? 273  PRO A CG  1 
ATOM   1987 C CD  A PRO A 1 192 ? 37.18019  -3.29678  -21.58765 0.748 9.81008  ? 273  PRO A CD  1 
ATOM   1988 C CD  B PRO A 1 192 ? 37.16223  -3.58330  -22.00151 0.252 8.65458  ? 273  PRO A CD  1 
ATOM   1989 N N   A ALA A 1 193 ? 34.72546  -5.23371  -19.49972 0.748 7.54889  ? 274  ALA A N   1 
ATOM   1990 N N   B ALA A 1 193 ? 34.57189  -5.50185  -19.82322 0.252 7.20743  ? 274  ALA A N   1 
ATOM   1991 C CA  A ALA A 1 193 ? 33.63236  -6.05521  -18.99554 0.748 7.80557  ? 274  ALA A CA  1 
ATOM   1992 C CA  B ALA A 1 193 ? 33.48702  -6.31112  -19.27647 0.252 8.16503  ? 274  ALA A CA  1 
ATOM   1993 C C   A ALA A 1 193 ? 34.11457  -7.46452  -18.67170 0.748 7.73849  ? 274  ALA A C   1 
ATOM   1994 C C   B ALA A 1 193 ? 33.94728  -7.73801  -19.00810 0.252 7.68582  ? 274  ALA A C   1 
ATOM   1995 O O   A ALA A 1 193 ? 33.83307  -7.99665  -17.58929 0.748 7.63714  ? 274  ALA A O   1 
ATOM   1996 O O   B ALA A 1 193 ? 33.68280  -8.29798  -17.93626 0.252 6.99798  ? 274  ALA A O   1 
ATOM   1997 C CB  A ALA A 1 193 ? 32.48932  -6.09012  -20.01286 0.748 8.58316  ? 274  ALA A CB  1 
ATOM   1998 C CB  B ALA A 1 193 ? 32.29723  -6.30127  -20.23583 0.252 7.14777  ? 274  ALA A CB  1 
ATOM   1999 N N   A ALA A 1 194 ? 34.84101  -8.08651  -19.60364 0.748 7.71671  ? 275  ALA A N   1 
ATOM   2000 N N   B ALA A 1 194 ? 34.63504  -8.34457  -19.97654 0.252 8.00726  ? 275  ALA A N   1 
ATOM   2001 C CA  A ALA A 1 194 ? 35.34641  -9.43503  -19.36412 0.748 8.13730  ? 275  ALA A CA  1 
ATOM   2002 C CA  B ALA A 1 194 ? 35.14440  -9.69591  -19.77977 0.252 7.86109  ? 275  ALA A CA  1 
ATOM   2003 C C   A ALA A 1 194 ? 36.23496  -9.46697  -18.13079 0.748 8.12255  ? 275  ALA A C   1 
ATOM   2004 C C   B ALA A 1 194 ? 36.05301  -9.77111  -18.56093 0.252 7.74092  ? 275  ALA A C   1 
ATOM   2005 O O   A ALA A 1 194 ? 36.15650  -10.40127 -17.32125 0.748 8.62712  ? 275  ALA A O   1 
ATOM   2006 O O   B ALA A 1 194 ? 35.95372  -10.71162 -17.76345 0.252 6.93004  ? 275  ALA A O   1 
ATOM   2007 C CB  A ALA A 1 194 ? 36.11521  -9.93632  -20.58641 0.748 9.13349  ? 275  ALA A CB  1 
ATOM   2008 C CB  B ALA A 1 194 ? 35.87222  -10.16888 -21.03680 0.252 7.84567  ? 275  ALA A CB  1 
ATOM   2009 N N   A GLN A 1 195 ? 37.07503  -8.44521  -17.96539 0.748 8.32071  ? 276  GLN A N   1 
ATOM   2010 N N   B GLN A 1 195 ? 36.93594  -8.78173  -18.39152 0.252 7.78170  ? 276  GLN A N   1 
ATOM   2011 C CA  A GLN A 1 195 ? 37.95234  -8.40418  -16.80229 0.748 9.44774  ? 276  GLN A CA  1 
ATOM   2012 C CA  B GLN A 1 195 ? 37.83552  -8.78172  -17.24225 0.252 8.10195  ? 276  GLN A CA  1 
ATOM   2013 C C   A GLN A 1 195 ? 37.15197  -8.35063  -15.50868 0.748 7.99772  ? 276  GLN A C   1 
ATOM   2014 C C   B GLN A 1 195 ? 37.06107  -8.75360  -15.93053 0.252 7.41438  ? 276  GLN A C   1 
ATOM   2015 O O   A GLN A 1 195 ? 37.48161  -9.04113  -14.53741 0.748 9.12164  ? 276  GLN A O   1 
ATOM   2016 O O   B GLN A 1 195 ? 37.38879  -9.49059  -14.99222 0.252 8.60655  ? 276  GLN A O   1 
ATOM   2017 C CB  A GLN A 1 195 ? 38.92810  -7.23392  -16.91049 0.748 9.67072  ? 276  GLN A CB  1 
ATOM   2018 C CB  B GLN A 1 195 ? 38.80279  -7.59826  -17.32862 0.252 7.18064  ? 276  GLN A CB  1 
ATOM   2019 C CG  A GLN A 1 195 ? 39.86910  -7.35712  -18.10353 0.748 11.18290 ? 276  GLN A CG  1 
ATOM   2020 C CG  B GLN A 1 195 ? 39.80885  -7.67811  -18.46505 0.252 10.29558 ? 276  GLN A CG  1 
ATOM   2021 C CD  A GLN A 1 195 ? 40.71952  -6.12474  -18.32876 0.748 12.16232 ? 276  GLN A CD  1 
ATOM   2022 C CD  B GLN A 1 195 ? 40.77464  -6.50724  -18.45616 0.252 13.46561 ? 276  GLN A CD  1 
ATOM   2023 O OE1 A GLN A 1 195 ? 41.45768  -5.70553  -17.44183 0.748 15.37300 ? 276  GLN A OE1 1 
ATOM   2024 O OE1 B GLN A 1 195 ? 40.40865  -5.38179  -18.79156 0.252 14.60749 ? 276  GLN A OE1 1 
ATOM   2025 N NE2 A GLN A 1 195 ? 40.59926  -5.52068  -19.51467 0.748 11.44893 ? 276  GLN A NE2 1 
ATOM   2026 N NE2 B GLN A 1 195 ? 42.01087  -6.76459  -18.05570 0.252 18.19967 ? 276  GLN A NE2 1 
ATOM   2027 N N   A LEU A 1 196 ? 36.09946  -7.53389  -15.47447 0.748 7.67542  ? 277  LEU A N   1 
ATOM   2028 N N   B LEU A 1 196 ? 36.01980  -7.92353  -15.85099 0.252 7.53226  ? 277  LEU A N   1 
ATOM   2029 C CA  A LEU A 1 196 ? 35.27531  -7.43084  -14.27795 0.748 8.28460  ? 277  LEU A CA  1 
ATOM   2030 C CA  B LEU A 1 196 ? 35.26756  -7.80480  -14.60667 0.252 8.55073  ? 277  LEU A CA  1 
ATOM   2031 C C   A LEU A 1 196 ? 34.54778  -8.73815  -13.99161 0.748 7.76605  ? 277  LEU A C   1 
ATOM   2032 C C   B LEU A 1 196 ? 34.52573  -9.09741  -14.28620 0.252 7.61735  ? 277  LEU A C   1 
ATOM   2033 O O   A LEU A 1 196 ? 34.57592  -9.23449  -12.86092 0.748 8.25152  ? 277  LEU A O   1 
ATOM   2034 O O   B LEU A 1 196 ? 34.58347  -9.59237  -13.15433 0.252 8.04454  ? 277  LEU A O   1 
ATOM   2035 C CB  A LEU A 1 196 ? 34.28242  -6.28268  -14.42865 0.748 8.05505  ? 277  LEU A CB  1 
ATOM   2036 C CB  B LEU A 1 196 ? 34.30018  -6.62045  -14.68433 0.252 9.52113  ? 277  LEU A CB  1 
ATOM   2037 C CG  A LEU A 1 196 ? 33.27860  -6.19768  -13.29034 0.748 10.52837 ? 277  LEU A CG  1 
ATOM   2038 C CG  B LEU A 1 196 ? 33.69193  -6.11545  -13.36776 0.252 10.61240 ? 277  LEU A CG  1 
ATOM   2039 C CD1 A LEU A 1 196 ? 33.97348  -5.85396  -11.98955 0.748 16.42200 ? 277  LEU A CD1 1 
ATOM   2040 C CD1 B LEU A 1 196 ? 32.30181  -6.69021  -13.15763 0.252 10.02812 ? 277  LEU A CD1 1 
ATOM   2041 C CD2 A LEU A 1 196 ? 32.21245  -5.17551  -13.62063 0.748 12.63342 ? 277  LEU A CD2 1 
ATOM   2042 C CD2 B LEU A 1 196 ? 34.59084  -6.41890  -12.17058 0.252 15.57182 ? 277  LEU A CD2 1 
ATOM   2043 N N   A PHE A 1 197 ? 33.86689  -9.29883  -14.99861 0.748 7.51150  ? 278  PHE A N   1 
ATOM   2044 N N   B PHE A 1 197 ? 33.83201  -9.66936  -15.27205 0.252 7.85124  ? 278  PHE A N   1 
ATOM   2045 C CA  A PHE A 1 197 ? 33.10597  -10.52900 -14.77600 0.748 8.05116  ? 278  PHE A CA  1 
ATOM   2046 C CA  B PHE A 1 197 ? 32.98983  -10.82264 -14.97178 0.252 7.71883  ? 278  PHE A CA  1 
ATOM   2047 C C   A PHE A 1 197 ? 34.01616  -11.67004 -14.34141 0.748 7.36456  ? 278  PHE A C   1 
ATOM   2048 C C   B PHE A 1 197 ? 33.82630  -12.05194 -14.63296 0.252 8.77494  ? 278  PHE A C   1 
ATOM   2049 O O   A PHE A 1 197 ? 33.64107  -12.48020 -13.48490 0.748 7.45888  ? 278  PHE A O   1 
ATOM   2050 O O   B PHE A 1 197 ? 33.44697  -12.84503 -13.76414 0.252 7.70946  ? 278  PHE A O   1 
ATOM   2051 C CB  A PHE A 1 197 ? 32.32712  -10.94795 -16.02864 0.748 8.47453  ? 278  PHE A CB  1 
ATOM   2052 C CB  B PHE A 1 197 ? 32.00343  -11.08748 -16.10471 0.252 9.16488  ? 278  PHE A CB  1 
ATOM   2053 C CG  A PHE A 1 197 ? 31.25123  -9.98487  -16.43819 0.748 9.07638  ? 278  PHE A CG  1 
ATOM   2054 C CG  B PHE A 1 197 ? 30.91127  -10.05660 -16.19489 0.252 8.96687  ? 278  PHE A CG  1 
ATOM   2055 C CD1 A PHE A 1 197 ? 30.32769  -9.53055  -15.52132 0.748 9.75216  ? 278  PHE A CD1 1 
ATOM   2056 C CD1 B PHE A 1 197 ? 29.94464  -9.96331  -15.20782 0.252 9.56081  ? 278  PHE A CD1 1 
ATOM   2057 C CD2 A PHE A 1 197 ? 31.14616  -9.55350  -17.75188 0.748 8.71936  ? 278  PHE A CD2 1 
ATOM   2058 C CD2 B PHE A 1 197 ? 30.84031  -9.19749  -17.28123 0.252 7.19928  ? 278  PHE A CD2 1 
ATOM   2059 C CE1 A PHE A 1 197 ? 29.33495  -8.63368  -15.89450 0.748 10.78142 ? 278  PHE A CE1 1 
ATOM   2060 C CE1 B PHE A 1 197 ? 28.94224  -9.01829  -15.29292 0.252 9.25423  ? 278  PHE A CE1 1 
ATOM   2061 C CE2 A PHE A 1 197 ? 30.15311  -8.65369  -18.12716 0.748 10.22663 ? 278  PHE A CE2 1 
ATOM   2062 C CE2 B PHE A 1 197 ? 29.83844  -8.25298  -17.37654 0.252 9.36092  ? 278  PHE A CE2 1 
ATOM   2063 C CZ  A PHE A 1 197 ? 29.25709  -8.19415  -17.19514 0.748 10.78572 ? 278  PHE A CZ  1 
ATOM   2064 C CZ  B PHE A 1 197 ? 28.89231  -8.16068  -16.37725 0.252 8.90567  ? 278  PHE A CZ  1 
ATOM   2065 N N   A THR A 1 198 ? 35.20604  -11.76525 -14.93558 0.748 7.73789  ? 279  THR A N   1 
ATOM   2066 N N   B THR A 1 198 ? 34.97750  -12.21681 -15.28639 0.252 8.39465  ? 279  THR A N   1 
ATOM   2067 C CA  A THR A 1 198 ? 36.13960  -12.81697 -14.55155 0.748 7.59594  ? 279  THR A CA  1 
ATOM   2068 C CA  B THR A 1 198 ? 35.86952  -13.31402 -14.92652 0.252 8.46882  ? 279  THR A CA  1 
ATOM   2069 C C   A THR A 1 198 ? 36.60421  -12.64828 -13.11056 0.748 7.17995  ? 279  THR A C   1 
ATOM   2070 C C   B THR A 1 198 ? 36.42939  -13.11084 -13.52510 0.252 7.62660  ? 279  THR A C   1 
ATOM   2071 O O   A THR A 1 198 ? 36.71707  -13.63251 -12.37328 0.748 8.10826  ? 279  THR A O   1 
ATOM   2072 O O   B THR A 1 198 ? 36.54597  -14.06469 -12.74401 0.252 8.17329  ? 279  THR A O   1 
ATOM   2073 C CB  A THR A 1 198 ? 37.32689  -12.81927 -15.50948 0.748 9.51225  ? 279  THR A CB  1 
ATOM   2074 C CB  B THR A 1 198 ? 37.01025  -13.38313 -15.93653 0.252 8.03794  ? 279  THR A CB  1 
ATOM   2075 O OG1 A THR A 1 198 ? 36.88226  -13.17332 -16.82698 0.748 12.74745 ? 279  THR A OG1 1 
ATOM   2076 O OG1 B THR A 1 198 ? 36.48590  -13.79985 -17.20400 0.252 9.79807  ? 279  THR A OG1 1 
ATOM   2077 C CG2 A THR A 1 198 ? 38.40641  -13.77493 -15.04552 0.748 12.28794 ? 279  THR A CG2 1 
ATOM   2078 C CG2 B THR A 1 198 ? 38.04900  -14.39886 -15.49223 0.252 12.38326 ? 279  THR A CG2 1 
ATOM   2079 N N   A GLN A 1 199 ? 36.85748  -11.41251 -12.67682 0.748 7.55799  ? 280  GLN A N   1 
ATOM   2080 N N   B GLN A 1 199 ? 36.79721  -11.86920 -13.20643 0.252 8.49180  ? 280  GLN A N   1 
ATOM   2081 C CA  A GLN A 1 199 ? 37.25054  -11.20518 -11.28442 0.748 8.44230  ? 280  GLN A CA  1 
ATOM   2082 C CA  B GLN A 1 199 ? 37.17369  -11.47638 -11.85087 0.252 9.50342  ? 280  GLN A CA  1 
ATOM   2083 C C   A GLN A 1 199 ? 36.13333  -11.60183 -10.32387 0.748 6.78101  ? 280  GLN A C   1 
ATOM   2084 C C   B GLN A 1 199 ? 36.12301  -11.88939 -10.81759 0.252 9.10928  ? 280  GLN A C   1 
ATOM   2085 O O   A GLN A 1 199 ? 36.38548  -12.19415 -9.26875  0.748 7.93366  ? 280  GLN A O   1 
ATOM   2086 O O   B GLN A 1 199 ? 36.44868  -12.50993 -9.79877  0.252 9.07200  ? 280  GLN A O   1 
ATOM   2087 C CB  A GLN A 1 199 ? 37.66547  -9.75352  -11.08068 0.748 9.55355  ? 280  GLN A CB  1 
ATOM   2088 C CB  B GLN A 1 199 ? 37.42113  -9.96048  -11.87906 0.252 13.53025 ? 280  GLN A CB  1 
ATOM   2089 C CG  A GLN A 1 199 ? 38.10663  -9.44993  -9.65802  0.748 13.50559 ? 280  GLN A CG  1 
ATOM   2090 C CG  B GLN A 1 199 ? 38.35946  -9.37661  -10.85621 0.252 17.09308 ? 280  GLN A CG  1 
ATOM   2091 C CD  A GLN A 1 199 ? 39.36742  -10.20021 -9.25806  0.748 12.52628 ? 280  GLN A CD  1 
ATOM   2092 C CD  B GLN A 1 199 ? 37.61543  -8.87542  -9.64122  0.252 14.53421 ? 280  GLN A CD  1 
ATOM   2093 O OE1 A GLN A 1 199 ? 39.32482  -11.10004 -8.41686  0.748 15.30340 ? 280  GLN A OE1 1 
ATOM   2094 O OE1 B GLN A 1 199 ? 36.72204  -9.53947  -9.12861  0.252 16.55726 ? 280  GLN A OE1 1 
ATOM   2095 N NE2 A GLN A 1 199 ? 40.49345  -9.84159  -9.86466  0.748 18.11161 ? 280  GLN A NE2 1 
ATOM   2096 N NE2 B GLN A 1 199 ? 37.96857  -7.67823  -9.18774  0.252 17.79402 ? 280  GLN A NE2 1 
ATOM   2097 N N   A VAL A 1 200 ? 34.89337  -11.27375 -10.67596 0.748 7.63262  ? 281  VAL A N   1 
ATOM   2098 N N   B VAL A 1 200 ? 34.85227  -11.57027 -11.07617 0.252 8.69686  ? 281  VAL A N   1 
ATOM   2099 C CA  A VAL A 1 200 ? 33.74248  -11.65989 -9.86754  0.748 7.35624  ? 281  VAL A CA  1 
ATOM   2100 C CA  B VAL A 1 200 ? 33.77855  -11.90688 -10.14255 0.252 8.70061  ? 281  VAL A CA  1 
ATOM   2101 C C   A VAL A 1 200 ? 33.64073  -13.18103 -9.78050  0.748 6.64496  ? 281  VAL A C   1 
ATOM   2102 C C   B VAL A 1 200 ? 33.59826  -13.42156 -10.04956 0.252 7.83668  ? 281  VAL A C   1 
ATOM   2103 O O   A VAL A 1 200 ? 33.45596  -13.75219 -8.69858  0.748 7.20766  ? 281  VAL A O   1 
ATOM   2104 O O   B VAL A 1 200 ? 33.35636  -13.97053 -8.96673  0.252 8.38407  ? 281  VAL A O   1 
ATOM   2105 C CB  A VAL A 1 200 ? 32.47536  -11.00351 -10.44251 0.748 8.08843  ? 281  VAL A CB  1 
ATOM   2106 C CB  B VAL A 1 200 ? 32.48460  -11.17035 -10.54666 0.252 8.18216  ? 281  VAL A CB  1 
ATOM   2107 C CG1 A VAL A 1 200 ? 31.20733  -11.61028 -9.86885  0.748 7.75892  ? 281  VAL A CG1 1 
ATOM   2108 C CG1 B VAL A 1 200 ? 31.35195  -11.49991 -9.59943  0.252 9.74300  ? 281  VAL A CG1 1 
ATOM   2109 C CG2 A VAL A 1 200 ? 32.52279  -9.49272  -10.21120 0.748 8.52234  ? 281  VAL A CG2 1 
ATOM   2110 C CG2 B VAL A 1 200 ? 32.71004  -9.66246  -10.57149 0.252 10.03542 ? 281  VAL A CG2 1 
ATOM   2111 N N   A TRP A 1 201 ? 33.77146  -13.85660 -10.92168 0.748 7.38440  ? 282  TRP A N   1 
ATOM   2112 N N   B TRP A 1 201 ? 33.72334  -14.11576 -11.18307 0.252 8.02124  ? 282  TRP A N   1 
ATOM   2113 C CA  A TRP A 1 201 ? 33.75327  -15.31484 -10.96451 0.748 7.74981  ? 282  TRP A CA  1 
ATOM   2114 C CA  B TRP A 1 201 ? 33.64616  -15.57322 -11.20501 0.252 6.83787  ? 282  TRP A CA  1 
ATOM   2115 C C   A TRP A 1 201 ? 34.86630  -15.91083 -10.10344 0.748 7.64162  ? 282  TRP A C   1 
ATOM   2116 C C   B TRP A 1 201 ? 34.74688  -16.18900 -10.34832 0.252 8.59345  ? 282  TRP A C   1 
ATOM   2117 O O   A TRP A 1 201 ? 34.62917  -16.85406 -9.33271  0.748 7.32523  ? 282  TRP A O   1 
ATOM   2118 O O   B TRP A 1 201 ? 34.51049  -17.15921 -9.61725  0.252 9.24560  ? 282  TRP A O   1 
ATOM   2119 C CB  A TRP A 1 201 ? 33.85602  -15.71435 -12.43654 0.748 7.88817  ? 282  TRP A CB  1 
ATOM   2120 C CB  B TRP A 1 201 ? 33.74881  -16.02878 -12.66100 0.252 8.26828  ? 282  TRP A CB  1 
ATOM   2121 C CG  A TRP A 1 201 ? 34.06856  -17.14265 -12.78074 0.748 7.35512  ? 282  TRP A CG  1 
ATOM   2122 C CG  B TRP A 1 201 ? 33.91505  -17.49848 -12.90467 0.252 8.01665  ? 282  TRP A CG  1 
ATOM   2123 C CD1 A TRP A 1 201 ? 33.14939  -18.14166 -12.75291 0.748 7.49603  ? 282  TRP A CD1 1 
ATOM   2124 C CD1 B TRP A 1 201 ? 32.96058  -18.46169 -12.76796 0.252 8.84821  ? 282  TRP A CD1 1 
ATOM   2125 C CD2 A TRP A 1 201 ? 35.26956  -17.71531 -13.30004 0.748 7.49365  ? 282  TRP A CD2 1 
ATOM   2126 C CD2 B TRP A 1 201 ? 35.09640  -18.16766 -13.37902 0.252 9.13179  ? 282  TRP A CD2 1 
ATOM   2127 N NE1 A TRP A 1 201 ? 33.71140  -19.32273 -13.19697 0.748 7.60262  ? 282  TRP A NE1 1 
ATOM   2128 N NE1 B TRP A 1 201 ? 33.47402  -19.68981 -13.11011 0.252 9.56913  ? 282  TRP A NE1 1 
ATOM   2129 C CE2 A TRP A 1 201 ? 35.01490  -19.08023 -13.54383 0.748 7.04717  ? 282  TRP A CE2 1 
ATOM   2130 C CE2 B TRP A 1 201 ? 34.78254  -19.53704 -13.48669 0.252 9.05935  ? 282  TRP A CE2 1 
ATOM   2131 C CE3 A TRP A 1 201 ? 36.53670  -17.20612 -13.57662 0.748 7.65578  ? 282  TRP A CE3 1 
ATOM   2132 C CE3 B TRP A 1 201 ? 36.39006  -17.74318 -13.71144 0.252 9.19797  ? 282  TRP A CE3 1 
ATOM   2133 C CZ2 A TRP A 1 201 ? 35.98607  -19.94115 -14.05208 0.748 8.21183  ? 282  TRP A CZ2 1 
ATOM   2134 C CZ2 B TRP A 1 201 ? 35.71172  -20.48633 -13.91262 0.252 11.94619 ? 282  TRP A CZ2 1 
ATOM   2135 C CZ3 A TRP A 1 201 ? 37.49888  -18.05616 -14.07885 0.748 8.81978  ? 282  TRP A CZ3 1 
ATOM   2136 C CZ3 B TRP A 1 201 ? 37.31277  -18.69043 -14.13827 0.252 8.72260  ? 282  TRP A CZ3 1 
ATOM   2137 C CH2 A TRP A 1 201 ? 37.21676  -19.41539 -14.31012 0.748 9.08168  ? 282  TRP A CH2 1 
ATOM   2138 C CH2 B TRP A 1 201 ? 36.96687  -20.04300 -14.23137 0.252 9.96856  ? 282  TRP A CH2 1 
ATOM   2139 N N   A GLN A 1 202 ? 36.07466  -15.34010 -10.18231 0.748 7.78219  ? 283  GLN A N   1 
ATOM   2140 N N   B GLN A 1 202 ? 35.95447  -15.61893 -10.40764 0.252 8.70732  ? 283  GLN A N   1 
ATOM   2141 C CA  A GLN A 1 202 ? 37.18803  -15.80860 -9.35640  0.748 7.66908  ? 283  GLN A CA  1 
ATOM   2142 C CA  B GLN A 1 202 ? 37.07141  -16.14991 -9.63105  0.252 8.42627  ? 283  GLN A CA  1 
ATOM   2143 C C   A GLN A 1 202 ? 36.89567  -15.64180 -7.86851  0.748 7.81020  ? 283  GLN A C   1 
ATOM   2144 C C   B GLN A 1 202 ? 36.88812  -15.88369 -8.14253  0.252 9.24187  ? 283  GLN A C   1 
ATOM   2145 O O   A GLN A 1 202 ? 37.19051  -16.53601 -7.06284  0.748 8.07406  ? 283  GLN A O   1 
ATOM   2146 O O   B GLN A 1 202 ? 37.10148  -16.78227 -7.31785  0.252 9.14293  ? 283  GLN A O   1 
ATOM   2147 C CB  A GLN A 1 202 ? 38.45379  -15.03180 -9.72403  0.748 8.86933  ? 283  GLN A CB  1 
ATOM   2148 C CB  B GLN A 1 202 ? 38.39112  -15.54819 -10.11832 0.252 9.26138  ? 283  GLN A CB  1 
ATOM   2149 C CG  A GLN A 1 202 ? 39.07245  -15.45907 -11.03072 0.748 11.01966 ? 283  GLN A CG  1 
ATOM   2150 C CG  B GLN A 1 202 ? 39.43480  -15.32999 -9.01216  0.252 10.64775 ? 283  GLN A CG  1 
ATOM   2151 C CD  A GLN A 1 202 ? 40.17473  -14.52989 -11.48854 0.748 12.41573 ? 283  GLN A CD  1 
ATOM   2152 C CD  B GLN A 1 202 ? 40.81814  -15.01188 -9.55001  0.252 15.86896 ? 283  GLN A CD  1 
ATOM   2153 O OE1 A GLN A 1 202 ? 40.37974  -13.45327 -10.92728 0.748 21.70234 ? 283  GLN A OE1 1 
ATOM   2154 O OE1 B GLN A 1 202 ? 41.13587  -15.32272 -10.69697 0.252 19.08876 ? 283  GLN A OE1 1 
ATOM   2155 N NE2 A GLN A 1 202 ? 40.88731  -14.94081 -12.53078 0.748 22.93814 ? 283  GLN A NE2 1 
ATOM   2156 N NE2 B GLN A 1 202 ? 41.65247  -14.39829 -8.71661  0.252 16.31211 ? 283  GLN A NE2 1 
ATOM   2157 N N   A ASN A 1 203 ? 36.33602  -14.49758 -7.47778  0.748 7.77693  ? 284  ASN A N   1 
ATOM   2158 N N   B ASN A 1 203 ? 36.49744  -14.65508 -7.77542  0.252 8.36756  ? 284  ASN A N   1 
ATOM   2159 C CA  A ASN A 1 203 ? 36.10905  -14.25607 -6.05572  0.748 7.76337  ? 284  ASN A CA  1 
ATOM   2160 C CA  B ASN A 1 203 ? 36.34497  -14.33381 -6.35843  0.252 8.71964  ? 284  ASN A CA  1 
ATOM   2161 C C   A ASN A 1 203 ? 35.08298  -15.21794 -5.47708  0.748 7.28532  ? 284  ASN A C   1 
ATOM   2162 C C   B ASN A 1 203 ? 35.26302  -15.17761 -5.70126  0.252 9.08915  ? 284  ASN A C   1 
ATOM   2163 O O   A ASN A 1 203 ? 35.18210  -15.58722 -4.29804  0.748 8.66229  ? 284  ASN A O   1 
ATOM   2164 O O   B ASN A 1 203 ? 35.35365  -15.47296 -4.50260  0.252 7.51519  ? 284  ASN A O   1 
ATOM   2165 C CB  A ASN A 1 203 ? 35.70666  -12.80262 -5.80226  0.748 8.93145  ? 284  ASN A CB  1 
ATOM   2166 C CB  B ASN A 1 203 ? 36.10019  -12.84046 -6.13242  0.252 10.21728 ? 284  ASN A CB  1 
ATOM   2167 C CG  A ASN A 1 203 ? 36.89384  -11.86433 -5.82087  0.748 8.18720  ? 284  ASN A CG  1 
ATOM   2168 C CG  B ASN A 1 203 ? 37.33774  -12.00849 -6.39059  0.252 10.44899 ? 284  ASN A CG  1 
ATOM   2169 O OD1 A ASN A 1 203 ? 38.03128  -12.29838 -5.67082  0.748 9.99731  ? 284  ASN A OD1 1 
ATOM   2170 O OD1 B ASN A 1 203 ? 37.30400  -11.03261 -7.12760  0.252 15.58471 ? 284  ASN A OD1 1 
ATOM   2171 N ND2 A ASN A 1 203 ? 36.63533  -10.57215 -5.97388  0.748 10.17878 ? 284  ASN A ND2 1 
ATOM   2172 N ND2 B ASN A 1 203 ? 38.45466  -12.43499 -5.82788  0.252 13.58400 ? 284  ASN A ND2 1 
ATOM   2173 N N   A ALA A 1 204 ? 34.12190  -15.65184 -6.28869  0.748 7.62270  ? 285  ALA A N   1 
ATOM   2174 N N   B ALA A 1 204 ? 34.25208  -15.58824 -6.47192  0.252 7.93965  ? 285  ALA A N   1 
ATOM   2175 C CA  A ALA A 1 204 ? 33.12247  -16.60913 -5.85915  0.748 8.27893  ? 285  ALA A CA  1 
ATOM   2176 C CA  B ALA A 1 204 ? 33.20462  -16.49724 -6.02662  0.252 8.26075  ? 285  ALA A CA  1 
ATOM   2177 C C   A ALA A 1 204 ? 33.58212  -18.04458 -6.05384  0.748 8.44137  ? 285  ALA A C   1 
ATOM   2178 C C   B ALA A 1 204 ? 33.58527  -17.96692 -6.20202  0.252 8.44996  ? 285  ALA A C   1 
ATOM   2179 O O   A ALA A 1 204 ? 32.75783  -18.96308 -5.98652  0.748 10.59415 ? 285  ALA A O   1 
ATOM   2180 O O   B ALA A 1 204 ? 32.70146  -18.83061 -6.28706  0.252 9.16448  ? 285  ALA A O   1 
ATOM   2181 C CB  A ALA A 1 204 ? 31.79612  -16.35120 -6.57052  0.748 8.76509  ? 285  ALA A CB  1 
ATOM   2182 C CB  B ALA A 1 204 ? 31.89709  -16.19536 -6.75895  0.252 8.45089  ? 285  ALA A CB  1 
ATOM   2183 N N   . GLY A 1 205 ? 34.87724  -18.25883 -6.28347  1.000 7.98515  ? 286  GLY A N   1 
ATOM   2184 C CA  . GLY A 1 205 ? 35.39539  -19.60875 -6.30100  1.000 9.09232  ? 286  GLY A CA  1 
ATOM   2185 C C   . GLY A 1 205 ? 35.23758  -20.36567 -7.59337  1.000 7.83115  ? 286  GLY A C   1 
ATOM   2186 O O   . GLY A 1 205 ? 35.43327  -21.58689 -7.59917  1.000 8.68152  ? 286  GLY A O   1 
ATOM   2187 N N   . LYS A 1 206 ? 34.90557  -19.68898 -8.68845  1.000 7.97015  ? 287  LYS A N   1 
ATOM   2188 C CA  . LYS A 1 206 ? 34.78161  -20.34815 -9.98527  1.000 8.09285  ? 287  LYS A CA  1 
ATOM   2189 C C   . LYS A 1 206 ? 33.75701  -21.48309 -9.93632  1.000 8.05990  ? 287  LYS A C   1 
ATOM   2190 O O   . LYS A 1 206 ? 33.89958  -22.48036 -10.63377 1.000 8.87169  ? 287  LYS A O   1 
ATOM   2191 C CB  . LYS A 1 206 ? 36.13149  -20.84272 -10.53395 1.000 8.12651  ? 287  LYS A CB  1 
ATOM   2192 C CG  . LYS A 1 206 ? 37.21476  -19.76691 -10.61033 1.000 9.18704  ? 287  LYS A CG  1 
ATOM   2193 C CD  . LYS A 1 206 ? 38.53906  -20.32321 -11.10077 1.000 10.16549 ? 287  LYS A CD  1 
ATOM   2194 C CE  . LYS A 1 206 ? 39.57591  -19.23190 -11.26736 1.000 10.83204 ? 287  LYS A CE  1 
ATOM   2195 N NZ  . LYS A 1 206 ? 40.88212  -19.81359 -11.67211 1.000 12.70148 ? 287  LYS A NZ  1 
ATOM   2196 N N   . SER A 1 207 ? 32.71171  -21.34863 -9.12553  1.000 8.28498  ? 288  SER A N   1 
ATOM   2197 C CA  . SER A 1 207 ? 31.76850  -22.44957 -8.95920  1.000 8.14033  ? 288  SER A CA  1 
ATOM   2198 C C   . SER A 1 207 ? 31.17766  -22.84623 -10.31022 1.000 7.77585  ? 288  SER A C   1 
ATOM   2199 O O   . SER A 1 207 ? 30.77727  -21.96860 -11.08607 1.000 7.69686  ? 288  SER A O   1 
ATOM   2200 C CB  . SER A 1 207 ? 30.61216  -22.02053 -8.06351  1.000 8.74021  ? 288  SER A CB  1 
ATOM   2201 O OG  . SER A 1 207 ? 29.59191  -23.01247 -8.06508  1.000 8.67864  ? 288  SER A OG  1 
ATOM   2202 N N   . PRO A 1 208 ? 31.05132  -24.14552 -10.60277 1.000 7.68536  ? 289  PRO A N   1 
ATOM   2203 C CA  A PRO A 1 208 ? 30.40154  -24.55510 -11.85721 0.555 8.13295  ? 289  PRO A CA  1 
ATOM   2204 C CA  B PRO A 1 208 ? 30.40713  -24.54329 -11.86277 0.445 8.17070  ? 289  PRO A CA  1 
ATOM   2205 C C   . PRO A 1 208 ? 28.95296  -24.12299 -11.95640 1.000 7.04979  ? 289  PRO A C   1 
ATOM   2206 O O   . PRO A 1 208 ? 28.40670  -24.10010 -13.06658 1.000 7.97462  ? 289  PRO A O   1 
ATOM   2207 C CB  A PRO A 1 208 ? 30.54672  -26.08185 -11.86193 0.555 10.31591 ? 289  PRO A CB  1 
ATOM   2208 C CB  B PRO A 1 208 ? 30.56466  -26.06622 -11.88243 0.445 10.30596 ? 289  PRO A CB  1 
ATOM   2209 C CG  A PRO A 1 208 ? 31.62147  -26.39532 -10.87772 0.555 11.32053 ? 289  PRO A CG  1 
ATOM   2210 C CG  B PRO A 1 208 ? 30.82651  -26.43820 -10.48251 0.445 9.19519  ? 289  PRO A CG  1 
ATOM   2211 C CD  A PRO A 1 208 ? 31.61859  -25.28736 -9.86479  0.555 8.52151  ? 289  PRO A CD  1 
ATOM   2212 C CD  B PRO A 1 208 ? 31.55941  -25.30597 -9.85660  0.445 8.53397  ? 289  PRO A CD  1 
ATOM   2213 N N   . PHE A 1 209 ? 28.31597  -23.76504 -10.83716 1.000 6.77753  ? 290  PHE A N   1 
ATOM   2214 C CA  . PHE A 1 209 ? 26.95165  -23.24746 -10.88036 1.000 7.22010  ? 290  PHE A CA  1 
ATOM   2215 C C   . PHE A 1 209 ? 26.87616  -21.83815 -11.45603 1.000 6.94288  ? 290  PHE A C   1 
ATOM   2216 O O   . PHE A 1 209 ? 25.77891  -21.39542 -11.81888 1.000 7.94393  ? 290  PHE A O   1 
ATOM   2217 C CB  . PHE A 1 209 ? 26.31052  -23.29957 -9.49082  1.000 7.32478  ? 290  PHE A CB  1 
ATOM   2218 C CG  . PHE A 1 209 ? 26.09836  -24.70104 -9.00014  1.000 7.13993  ? 290  PHE A CG  1 
ATOM   2219 C CD1 . PHE A 1 209 ? 25.14410  -25.52046 -9.57991  1.000 8.43527  ? 290  PHE A CD1 1 
ATOM   2220 C CD2 . PHE A 1 209 ? 26.87672  -25.21566 -7.98247  1.000 8.03502  ? 290  PHE A CD2 1 
ATOM   2221 C CE1 . PHE A 1 209 ? 24.97165  -26.82196 -9.14277  1.000 9.64373  ? 290  PHE A CE1 1 
ATOM   2222 C CE2 . PHE A 1 209 ? 26.70567  -26.51776 -7.54241  1.000 9.41547  ? 290  PHE A CE2 1 
ATOM   2223 C CZ  . PHE A 1 209 ? 25.75220  -27.31834 -8.12582  1.000 10.04987 ? 290  PHE A CZ  1 
ATOM   2224 N N   . ILE A 1 210 ? 27.99973  -21.12583 -11.52598 1.000 6.85826  ? 291  ILE A N   1 
ATOM   2225 C CA  . ILE A 1 210 ? 28.04928  -19.81013 -12.14912 1.000 7.39818  ? 291  ILE A CA  1 
ATOM   2226 C C   . ILE A 1 210 ? 28.21774  -20.06282 -13.64063 1.000 6.67837  ? 291  ILE A C   1 
ATOM   2227 O O   . ILE A 1 210 ? 29.33615  -20.19445 -14.15670 1.000 7.73075  ? 291  ILE A O   1 
ATOM   2228 C CB  . ILE A 1 210 ? 29.16227  -18.92244 -11.55858 1.000 7.82593  ? 291  ILE A CB  1 
ATOM   2229 C CG1 . ILE A 1 210 ? 29.03982  -18.84889 -10.03476 1.000 8.55930  ? 291  ILE A CG1 1 
ATOM   2230 C CG2 . ILE A 1 210 ? 29.09898  -17.55040 -12.18027 1.000 8.97460  ? 291  ILE A CG2 1 
ATOM   2231 C CD1 . ILE A 1 210 ? 30.23913  -18.21516 -9.36252  1.000 10.57107 ? 291  ILE A CD1 1 
ATOM   2232 N N   . LYS A 1 211 ? 27.08878  -20.20004 -14.34008 1.000 7.17100  ? 292  LYS A N   1 
ATOM   2233 C CA  A LYS A 1 211 ? 27.11887  -20.69046 -15.71314 0.827 7.29170  ? 292  LYS A CA  1 
ATOM   2234 C CA  B LYS A 1 211 ? 27.11531  -20.69480 -15.71135 0.173 7.33587  ? 292  LYS A CA  1 
ATOM   2235 C C   . LYS A 1 211 ? 27.60120  -19.64296 -16.69240 1.000 6.78219  ? 292  LYS A C   1 
ATOM   2236 O O   . LYS A 1 211 ? 28.21508  -19.98501 -17.70638 1.000 7.58710  ? 292  LYS A O   1 
ATOM   2237 C CB  A LYS A 1 211 ? 25.74371  -21.18886 -16.14354 0.827 8.44706  ? 292  LYS A CB  1 
ATOM   2238 C CB  B LYS A 1 211 ? 25.72159  -21.16503 -16.12778 0.173 8.38938  ? 292  LYS A CB  1 
ATOM   2239 C CG  A LYS A 1 211 ? 25.28002  -22.39649 -15.36968 0.827 8.82669  ? 292  LYS A CG  1 
ATOM   2240 C CG  B LYS A 1 211 ? 25.17975  -22.31950 -15.30471 0.173 8.78284  ? 292  LYS A CG  1 
ATOM   2241 C CD  A LYS A 1 211 ? 26.09127  -23.66822 -15.66823 0.827 8.72532  ? 292  LYS A CD  1 
ATOM   2242 C CD  B LYS A 1 211 ? 26.05802  -23.55997 -15.41583 0.173 9.67179  ? 292  LYS A CD  1 
ATOM   2243 C CE  A LYS A 1 211 ? 25.41637  -24.52759 -16.71259 0.827 9.15018  ? 292  LYS A CE  1 
ATOM   2244 C CE  B LYS A 1 211 ? 25.48013  -24.57676 -16.38901 0.173 8.92418  ? 292  LYS A CE  1 
ATOM   2245 N NZ  A LYS A 1 211 ? 26.28195  -25.67012 -17.12051 0.827 9.43436  ? 292  LYS A NZ  1 
ATOM   2246 N NZ  B LYS A 1 211 ? 25.24118  -23.99148 -17.73433 0.173 11.11517 ? 292  LYS A NZ  1 
ATOM   2247 N N   . GLY A 1 212 ? 27.32454  -18.37428 -16.42359 1.000 7.11270  ? 293  GLY A N   1 
ATOM   2248 C CA  . GLY A 1 212 ? 27.65542  -17.33838 -17.37119 1.000 7.15738  ? 293  GLY A CA  1 
ATOM   2249 C C   . GLY A 1 212 ? 26.87224  -16.07850 -17.11258 1.000 6.42111  ? 293  GLY A C   1 
ATOM   2250 O O   . GLY A 1 212 ? 26.77437  -15.63633 -15.96199 1.000 6.82547  ? 293  GLY A O   1 
ATOM   2251 N N   . LEU A 1 213 ? 26.32980  -15.49931 -18.18414 1.000 6.46436  ? 294  LEU A N   1 
ATOM   2252 C CA  . LEU A 1 213 ? 25.81218  -14.14489 -18.18453 1.000 6.71164  ? 294  LEU A CA  1 
ATOM   2253 C C   . LEU A 1 213 ? 24.42717  -14.09565 -18.81224 1.000 5.95249  ? 294  LEU A C   1 
ATOM   2254 O O   . LEU A 1 213 ? 24.10084  -14.89229 -19.68500 1.000 7.05191  ? 294  LEU A O   1 
ATOM   2255 C CB  . LEU A 1 213 ? 26.74874  -13.21788 -18.96317 1.000 6.97694  ? 294  LEU A CB  1 
ATOM   2256 C CG  . LEU A 1 213 ? 28.19717  -13.13775 -18.49265 1.000 8.24947  ? 294  LEU A CG  1 
ATOM   2257 C CD1 . LEU A 1 213 ? 28.99806  -12.21048 -19.39526 1.000 8.75686  ? 294  LEU A CD1 1 
ATOM   2258 C CD2 . LEU A 1 213 ? 28.28316  -12.70688 -17.04001 1.000 8.64945  ? 294  LEU A CD2 1 
ATOM   2259 N N   . ALA A 1 214 ? 23.63048  -13.12957 -18.36543 1.000 6.23970  ? 295  ALA A N   1 
ATOM   2260 C CA  . ALA A 1 214 ? 22.32474  -12.82035 -18.93519 1.000 6.45925  ? 295  ALA A CA  1 
ATOM   2261 C C   . ALA A 1 214 ? 22.39502  -11.47070 -19.63746 1.000 6.27270  ? 295  ALA A C   1 
ATOM   2262 O O   . ALA A 1 214 ? 22.96380  -10.51713 -19.09394 1.000 7.68653  ? 295  ALA A O   1 
ATOM   2263 C CB  . ALA A 1 214 ? 21.28335  -12.74094 -17.83349 1.000 6.90922  ? 295  ALA A CB  1 
ATOM   2264 N N   . THR A 1 215 ? 21.81635  -11.38153 -20.83433 1.000 6.23913  ? 296  THR A N   1 
ATOM   2265 C CA  . THR A 1 215 ? 21.85774  -10.13726 -21.58447 1.000 6.45595  ? 296  THR A CA  1 
ATOM   2266 C C   . THR A 1 215 ? 20.46062  -9.69495  -21.99470 1.000 6.07779  ? 296  THR A C   1 
ATOM   2267 O O   . THR A 1 215 ? 19.51154  -10.48116 -22.06244 1.000 6.71215  ? 296  THR A O   1 
ATOM   2268 C CB  . THR A 1 215 ? 22.79301  -10.18849 -22.81598 1.000 6.87994  ? 296  THR A CB  1 
ATOM   2269 O OG1 . THR A 1 215 ? 22.11334  -10.79123 -23.92516 1.000 7.73808  ? 296  THR A OG1 1 
ATOM   2270 C CG2 . THR A 1 215 ? 24.07565  -10.94253 -22.52103 1.000 8.30097  ? 296  THR A CG2 1 
ATOM   2271 N N   . ASN A 1 216 ? 20.35918  -8.39449  -22.27290 1.000 6.28337  ? 297  ASN A N   1 
ATOM   2272 C CA  . ASN A 1 216 ? 19.13491  -7.74616  -22.72853 1.000 6.73778  ? 297  ASN A CA  1 
ATOM   2273 C C   . ASN A 1 216 ? 18.02144  -7.75707  -21.69088 1.000 6.68290  ? 297  ASN A C   1 
ATOM   2274 O O   . ASN A 1 216 ? 16.86569  -7.51757  -22.05550 1.000 6.57847  ? 297  ASN A O   1 
ATOM   2275 C CB  . ASN A 1 216 ? 18.63333  -8.31531  -24.06374 1.000 7.08721  ? 297  ASN A CB  1 
ATOM   2276 C CG  . ASN A 1 216 ? 17.75089  -7.34507  -24.82502 1.000 7.36119  ? 297  ASN A CG  1 
ATOM   2277 O OD1 . ASN A 1 216 ? 18.12300  -6.19511  -25.05099 1.000 7.56583  ? 297  ASN A OD1 1 
ATOM   2278 N ND2 . ASN A 1 216 ? 16.60078  -7.82026  -25.26207 1.000 7.80063  ? 297  ASN A ND2 1 
ATOM   2279 N N   . VAL A 1 217 ? 18.34683  -8.03053  -20.41961 1.000 6.63072  ? 298  VAL A N   1 
ATOM   2280 C CA  . VAL A 1 217 ? 17.32169  -8.09404  -19.38897 1.000 6.58797  ? 298  VAL A CA  1 
ATOM   2281 C C   . VAL A 1 217 ? 16.57579  -6.77369  -19.32078 1.000 6.96346  ? 298  VAL A C   1 
ATOM   2282 O O   . VAL A 1 217 ? 17.17992  -5.70422  -19.17524 1.000 7.30879  ? 298  VAL A O   1 
ATOM   2283 C CB  . VAL A 1 217 ? 17.94802  -8.44599  -18.03175 1.000 6.95120  ? 298  VAL A CB  1 
ATOM   2284 C CG1 . VAL A 1 217 ? 16.91440  -8.36832  -16.92244 1.000 7.44470  ? 298  VAL A CG1 1 
ATOM   2285 C CG2 . VAL A 1 217 ? 18.58515  -9.85479  -18.08437 1.000 7.43990  ? 298  VAL A CG2 1 
ATOM   2286 N N   . ALA A 1 218 ? 15.24879  -6.84585  -19.40756 1.000 6.67873  ? 299  ALA A N   1 
ATOM   2287 C CA  . ALA A 1 218 ? 14.38058  -5.68042  -19.34596 1.000 7.63537  ? 299  ALA A CA  1 
ATOM   2288 C C   . ALA A 1 218 ? 14.59946  -4.71170  -20.49980 1.000 7.39656  ? 299  ALA A C   1 
ATOM   2289 O O   . ALA A 1 218 ? 14.08987  -3.58657  -20.45641 1.000 9.29238  ? 299  ALA A O   1 
ATOM   2290 C CB  . ALA A 1 218 ? 14.44522  -4.96181  -17.98874 1.000 8.70125  ? 299  ALA A CB  1 
ATOM   2291 N N   . ASN A 1 219 ? 15.29349  -5.13204  -21.55351 1.000 7.40360  ? 300  ASN A N   1 
ATOM   2292 C CA  . ASN A 1 219 ? 15.56055  -4.27516  -22.68171 1.000 7.35244  ? 300  ASN A CA  1 
ATOM   2293 C C   . ASN A 1 219 ? 14.81261  -4.77678  -23.92277 1.000 7.10744  ? 300  ASN A C   1 
ATOM   2294 O O   . ASN A 1 219 ? 13.88690  -5.59029  -23.81074 1.000 7.97054  ? 300  ASN A O   1 
ATOM   2295 C CB  . ASN A 1 219 ? 17.07351  -4.07719  -22.84513 1.000 8.51858  ? 300  ASN A CB  1 
ATOM   2296 C CG  . ASN A 1 219 ? 17.41801  -2.72798  -23.44790 1.000 8.20364  ? 300  ASN A CG  1 
ATOM   2297 O OD1 . ASN A 1 219 ? 17.25516  -2.52866  -24.65213 1.000 10.23018 ? 300  ASN A OD1 1 
ATOM   2298 N ND2 . ASN A 1 219 ? 17.90386  -1.79813  -22.62754 1.000 11.85838 ? 300  ASN A ND2 1 
ATOM   2299 N N   . TYR A 1 220 ? 15.21479  -4.27281  -25.09778 1.000 7.51888  ? 301  TYR A N   1 
ATOM   2300 C CA  A TYR A 1 220 ? 14.40950  -4.36850  -26.30575 0.537 8.00041  ? 301  TYR A CA  1 
ATOM   2301 C CA  B TYR A 1 220 ? 14.41217  -4.38205  -26.30899 0.463 8.04067  ? 301  TYR A CA  1 
ATOM   2302 C C   . TYR A 1 220 ? 15.23916  -4.76695  -27.52503 1.000 7.59297  ? 301  TYR A C   1 
ATOM   2303 O O   . TYR A 1 220 ? 14.71018  -4.75063  -28.64571 1.000 8.16352  ? 301  TYR A O   1 
ATOM   2304 C CB  A TYR A 1 220 ? 13.69844  -3.02942  -26.57695 0.537 8.65330  ? 301  TYR A CB  1 
ATOM   2305 C CB  B TYR A 1 220 ? 13.70542  -3.06573  -26.62713 0.463 8.65323  ? 301  TYR A CB  1 
ATOM   2306 C CG  A TYR A 1 220 ? 12.78215  -2.50168  -25.47434 0.537 7.87480  ? 301  TYR A CG  1 
ATOM   2307 C CG  B TYR A 1 220 ? 13.04904  -2.38283  -25.45932 0.463 7.66812  ? 301  TYR A CG  1 
ATOM   2308 C CD1 A TYR A 1 220 ? 13.26408  -1.64833  -24.48225 0.537 9.14357  ? 301  TYR A CD1 1 
ATOM   2309 C CD1 B TYR A 1 220 ? 13.77621  -1.56895  -24.60525 0.463 9.52448  ? 301  TYR A CD1 1 
ATOM   2310 C CD2 A TYR A 1 220 ? 11.42851  -2.81830  -25.45810 0.537 8.25442  ? 301  TYR A CD2 1 
ATOM   2311 C CD2 B TYR A 1 220 ? 11.69207  -2.54175  -25.22342 0.463 8.71110  ? 301  TYR A CD2 1 
ATOM   2312 C CE1 A TYR A 1 220 ? 12.42201  -1.13201  -23.49723 0.537 10.07849 ? 301  TYR A CE1 1 
ATOM   2313 C CE1 B TYR A 1 220 ? 13.16525  -0.92840  -23.54772 0.463 9.96999  ? 301  TYR A CE1 1 
ATOM   2314 C CE2 A TYR A 1 220 ? 10.58360  -2.32204  -24.47080 0.537 8.11088  ? 301  TYR A CE2 1 
ATOM   2315 C CE2 B TYR A 1 220 ? 11.07306  -1.90768  -24.17306 0.463 8.97075  ? 301  TYR A CE2 1 
ATOM   2316 C CZ  A TYR A 1 220 ? 11.08212  -1.47569  -23.49914 0.537 9.28976  ? 301  TYR A CZ  1 
ATOM   2317 C CZ  B TYR A 1 220 ? 11.80972  -1.10041  -23.33704 0.463 9.00609  ? 301  TYR A CZ  1 
ATOM   2318 O OH  A TYR A 1 220 ? 10.24055  -0.96990  -22.52718 0.537 10.87500 ? 301  TYR A OH  1 
ATOM   2319 O OH  B TYR A 1 220 ? 11.17276  -0.47227  -22.29269 0.463 10.40600 ? 301  TYR A OH  1 
ATOM   2320 N N   . ASN A 1 221 ? 16.51696  -5.08835  -27.35296 1.000 7.51861  ? 302  ASN A N   1 
ATOM   2321 C CA  . ASN A 1 221 ? 17.35894  -5.36424  -28.50970 1.000 7.57709  ? 302  ASN A CA  1 
ATOM   2322 C C   . ASN A 1 221 ? 16.94595  -6.66108  -29.19835 1.000 7.17881  ? 302  ASN A C   1 
ATOM   2323 O O   . ASN A 1 221 ? 16.39911  -7.58134  -28.58192 1.000 7.70726  ? 302  ASN A O   1 
ATOM   2324 C CB  . ASN A 1 221 ? 18.81844  -5.51948  -28.10948 1.000 7.40879  ? 302  ASN A CB  1 
ATOM   2325 C CG  . ASN A 1 221 ? 19.45830  -4.23123  -27.61556 1.000 7.72625  ? 302  ASN A CG  1 
ATOM   2326 O OD1 . ASN A 1 221 ? 18.89221  -3.13784  -27.70045 1.000 8.35738  ? 302  ASN A OD1 1 
ATOM   2327 N ND2 . ASN A 1 221 ? 20.67432  -4.36576  -27.10446 1.000 8.63993  ? 302  ASN A ND2 1 
ATOM   2328 N N   . ALA A 1 222 ? 17.24542  -6.73535  -30.48794 1.000 8.09493  ? 303  ALA A N   1 
ATOM   2329 C CA  . ALA A 1 222 ? 17.12297  -7.98766  -31.20800 1.000 8.63561  ? 303  ALA A CA  1 
ATOM   2330 C C   . ALA A 1 222 ? 18.20093  -8.95148  -30.74530 1.000 7.88645  ? 303  ALA A C   1 
ATOM   2331 O O   . ALA A 1 222 ? 19.30793  -8.54588  -30.39950 1.000 8.17964  ? 303  ALA A O   1 
ATOM   2332 C CB  . ALA A 1 222 ? 17.30843  -7.75086  -32.70284 1.000 9.58412  ? 303  ALA A CB  1 
ATOM   2333 N N   . LEU A 1 223 ? 17.87094  -10.24432 -30.74760 1.000 8.93954  ? 304  LEU A N   1 
ATOM   2334 C CA  . LEU A 1 223 ? 18.91713  -11.25995 -30.70113 1.000 8.74891  ? 304  LEU A CA  1 
ATOM   2335 C C   . LEU A 1 223 ? 19.68501  -11.28058 -32.01711 1.000 8.61852  ? 304  LEU A C   1 
ATOM   2336 O O   . LEU A 1 223 ? 20.92046  -11.20028 -32.03085 1.000 9.31518  ? 304  LEU A O   1 
ATOM   2337 C CB  . LEU A 1 223 ? 18.32343  -12.63317 -30.38458 1.000 9.50674  ? 304  LEU A CB  1 
ATOM   2338 C CG  . LEU A 1 223 ? 19.29373  -13.81863 -30.42704 1.000 9.21429  ? 304  LEU A CG  1 
ATOM   2339 C CD1 . LEU A 1 223 ? 20.50729  -13.58676 -29.53645 1.000 9.83963  ? 304  LEU A CD1 1 
ATOM   2340 C CD2 . LEU A 1 223 ? 18.55765  -15.08931 -30.03579 1.000 12.10892 ? 304  LEU A CD2 1 
ATOM   2341 N N   A GLN A 1 224 ? 18.97610  -11.42034 -33.13641 0.628 10.45704 ? 305  GLN A N   1 
ATOM   2342 N N   B GLN A 1 224 ? 18.96090  -11.32496 -33.13710 0.372 10.32987 ? 305  GLN A N   1 
ATOM   2343 C CA  A GLN A 1 224 ? 19.59019  -11.39218 -34.46338 0.628 11.92894 ? 305  GLN A CA  1 
ATOM   2344 C CA  B GLN A 1 224 ? 19.54828  -11.31055 -34.47255 0.372 11.90537 ? 305  GLN A CA  1 
ATOM   2345 C C   A GLN A 1 224 ? 18.73620  -10.49122 -35.34936 0.628 10.95547 ? 305  GLN A C   1 
ATOM   2346 C C   B GLN A 1 224 ? 18.75610  -10.35052 -35.34743 0.372 10.93066 ? 305  GLN A C   1 
ATOM   2347 O O   A GLN A 1 224 ? 17.67729  -10.90237 -35.83540 0.628 11.99704 ? 305  GLN A O   1 
ATOM   2348 O O   B GLN A 1 224 ? 17.54506  -10.52163 -35.52719 0.372 11.86329 ? 305  GLN A O   1 
ATOM   2349 C CB  A GLN A 1 224 ? 19.72618  -12.78866 -35.05752 0.628 12.63834 ? 305  GLN A CB  1 
ATOM   2350 C CB  B GLN A 1 224 ? 19.54511  -12.71176 -35.08989 0.372 13.13728 ? 305  GLN A CB  1 
ATOM   2351 C CG  A GLN A 1 224 ? 20.29405  -12.76415 -36.46235 0.628 14.41379 ? 305  GLN A CG  1 
ATOM   2352 C CG  B GLN A 1 224 ? 20.85674  -13.09148 -35.75487 0.372 17.62585 ? 305  GLN A CG  1 
ATOM   2353 C CD  A GLN A 1 224 ? 21.12068  -13.99085 -36.79653 0.628 20.48643 ? 305  GLN A CD  1 
ATOM   2354 C CD  B GLN A 1 224 ? 20.80115  -14.44734 -36.43062 0.372 19.61980 ? 305  GLN A CD  1 
ATOM   2355 O OE1 A GLN A 1 224 ? 21.77533  -14.57785 -35.93284 0.628 17.19578 ? 305  GLN A OE1 1 
ATOM   2356 O OE1 B GLN A 1 224 ? 21.63789  -15.31380 -36.17820 0.372 22.87893 ? 305  GLN A OE1 1 
ATOM   2357 N NE2 A GLN A 1 224 ? 21.09657  -14.38300 -38.06417 0.628 22.83005 ? 305  GLN A NE2 1 
ATOM   2358 N NE2 B GLN A 1 224 ? 19.81258  -14.63617 -37.29762 0.372 21.79171 ? 305  GLN A NE2 1 
ATOM   2359 N N   A ALA A 1 225 ? 19.20812  -9.26703  -35.54835 0.628 11.51330 ? 306  ALA A N   1 
ATOM   2360 N N   B ALA A 1 225 ? 19.43900  -9.35241  -35.89731 0.372 11.20297 ? 306  ALA A N   1 
ATOM   2361 C CA  A ALA A 1 225 ? 18.45431  -8.24910  -36.26037 0.628 12.68521 ? 306  ALA A CA  1 
ATOM   2362 C CA  B ALA A 1 225 ? 18.80928  -8.33269  -36.72584 0.372 12.91126 ? 306  ALA A CA  1 
ATOM   2363 C C   A ALA A 1 225 ? 18.52505  -8.48783  -37.75947 0.628 12.03586 ? 306  ALA A C   1 
ATOM   2364 C C   B ALA A 1 225 ? 19.39597  -8.40271  -38.12725 0.372 11.59698 ? 306  ALA A C   1 
ATOM   2365 O O   A ALA A 1 225 ? 19.56868  -8.87160  -38.29364 0.628 13.58750 ? 306  ALA A O   1 
ATOM   2366 O O   B ALA A 1 225 ? 20.61596  -8.31084  -38.29616 0.372 14.24551 ? 306  ALA A O   1 
ATOM   2367 C CB  A ALA A 1 225 ? 19.03808  -6.87188  -35.95375 0.628 13.85399 ? 306  ALA A CB  1 
ATOM   2368 C CB  B ALA A 1 225 ? 19.03027  -6.94309  -36.12752 0.372 13.48307 ? 306  ALA A CB  1 
ATOM   2369 N N   A ALA A 1 226 ? 17.40810  -8.22847  -38.44203 0.628 12.17598 ? 307  ALA A N   1 
ATOM   2370 N N   B ALA A 1 226 ? 18.52911  -8.57416  -39.12860 0.372 12.64301 ? 307  ALA A N   1 
ATOM   2371 C CA  A ALA A 1 226 ? 17.39265  -8.33276  -39.89770 0.628 15.25958 ? 307  ALA A CA  1 
ATOM   2372 C CA  B ALA A 1 226 ? 18.99319  -8.50712  -40.50948 0.372 13.35854 ? 307  ALA A CA  1 
ATOM   2373 C C   A ALA A 1 226 ? 18.28568  -7.27418  -40.53642 0.628 14.22666 ? 307  ALA A C   1 
ATOM   2374 C C   B ALA A 1 226 ? 19.44040  -7.09897  -40.87362 0.372 14.61013 ? 307  ALA A C   1 
ATOM   2375 O O   A ALA A 1 226 ? 18.92509  -7.52642  -41.56408 0.628 16.29155 ? 307  ALA A O   1 
ATOM   2376 O O   B ALA A 1 226 ? 20.37667  -6.93084  -41.66259 0.372 17.96350 ? 307  ALA A O   1 
ATOM   2377 C CB  A ALA A 1 226 ? 15.95861  -8.22010  -40.41320 0.628 17.82857 ? 307  ALA A CB  1 
ATOM   2378 C CB  B ALA A 1 226 ? 17.89740  -8.98355  -41.46293 0.372 15.37259 ? 307  ALA A CB  1 
ATOM   2379 N N   A SER A 1 227 ? 18.32401  -6.08269  -39.95292 0.628 13.74935 ? 308  SER A N   1 
ATOM   2380 N N   B SER A 1 227 ? 18.79037  -6.08314  -40.30916 0.372 12.40761 ? 308  SER A N   1 
ATOM   2381 C CA  A SER A 1 227 ? 19.23244  -5.01136  -40.33550 0.628 12.82461 ? 308  SER A CA  1 
ATOM   2382 C CA  B SER A 1 227 ? 19.12906  -4.68813  -40.56566 0.372 14.11348 ? 308  SER A CA  1 
ATOM   2383 C C   A SER A 1 227 ? 19.44459  -4.15380  -39.10136 0.628 12.22195 ? 308  SER A C   1 
ATOM   2384 C C   B SER A 1 227 ? 19.37588  -4.00412  -39.22818 0.372 12.36398 ? 308  SER A C   1 
ATOM   2385 O O   A SER A 1 227 ? 18.61345  -4.17438  -38.18655 0.628 12.19082 ? 308  SER A O   1 
ATOM   2386 O O   B SER A 1 227 ? 18.48451  -4.01901  -38.35264 0.372 12.19138 ? 308  SER A O   1 
ATOM   2387 C CB  A SER A 1 227 ? 18.64743  -4.16202  -41.47119 0.628 14.29150 ? 308  SER A CB  1 
ATOM   2388 C CB  B SER A 1 227 ? 18.02133  -3.97956  -41.34975 0.372 15.00192 ? 308  SER A CB  1 
ATOM   2389 O OG  A SER A 1 227 ? 17.43947  -3.53953  -41.07050 0.628 15.38818 ? 308  SER A OG  1 
ATOM   2390 O OG  B SER A 1 227 ? 16.81906  -3.91645  -40.60386 0.372 18.37349 ? 308  SER A OG  1 
ATOM   2391 N N   . PRO A 1 228 ? 20.55041  -3.41150  -39.02134 1.000 10.73395 ? 309  PRO A N   1 
ATOM   2392 C CA  . PRO A 1 228 ? 20.82829  -2.70642  -37.76299 1.000 10.37475 ? 309  PRO A CA  1 
ATOM   2393 C C   . PRO A 1 228 ? 19.80178  -1.62125  -37.48013 1.000 9.63615  ? 309  PRO A C   1 
ATOM   2394 O O   . PRO A 1 228 ? 19.39283  -0.87886  -38.37429 1.000 10.54390 ? 309  PRO A O   1 
ATOM   2395 C CB  . PRO A 1 228 ? 22.21940  -2.10874  -37.99327 1.000 12.77131 ? 309  PRO A CB  1 
ATOM   2396 C CG  . PRO A 1 228 ? 22.82990  -2.98896  -39.01843 1.000 13.99331 ? 309  PRO A CG  1 
ATOM   2397 C CD  . PRO A 1 228 ? 21.70267  -3.35877  -39.93685 1.000 14.10554 ? 309  PRO A CD  1 
ATOM   2398 N N   . ASP A 1 229 ? 19.37562  -1.55697  -36.22464 1.000 9.75592  ? 310  ASP A N   1 
ATOM   2399 C CA  . ASP A 1 229 ? 18.51115  -0.47704  -35.77132 1.000 9.26438  ? 310  ASP A CA  1 
ATOM   2400 C C   . ASP A 1 229 ? 19.31778  0.81710   -35.83875 1.000 9.12891  ? 310  ASP A C   1 
ATOM   2401 O O   . ASP A 1 229 ? 20.48335  0.83213   -35.42886 1.000 9.65142  ? 310  ASP A O   1 
ATOM   2402 C CB  . ASP A 1 229 ? 18.12095  -0.83026  -34.33068 1.000 9.35805  ? 310  ASP A CB  1 
ATOM   2403 C CG  . ASP A 1 229 ? 17.05066  0.08090   -33.71788 1.000 8.87628  ? 310  ASP A CG  1 
ATOM   2404 O OD1 . ASP A 1 229 ? 17.10252  1.30932   -33.94815 1.000 9.71607  ? 310  ASP A OD1 1 
ATOM   2405 O OD2 . ASP A 1 229 ? 16.20169  -0.44989  -32.95150 1.000 9.03519  ? 310  ASP A OD2 1 
ATOM   2406 N N   . PRO A 1 230 ? 18.76100  1.90747   -36.36896 1.000 9.50262  ? 311  PRO A N   1 
ATOM   2407 C CA  . PRO A 1 230 ? 19.53193  3.15892   -36.45606 1.000 10.86787 ? 311  PRO A CA  1 
ATOM   2408 C C   . PRO A 1 230 ? 20.15305  3.62503   -35.14398 1.000 9.28268  ? 311  PRO A C   1 
ATOM   2409 O O   . PRO A 1 230 ? 21.15921  4.34048   -35.16442 1.000 10.13974 ? 311  PRO A O   1 
ATOM   2410 C CB  . PRO A 1 230 ? 18.50632  4.16886   -36.98911 1.000 12.60167 ? 311  PRO A CB  1 
ATOM   2411 C CG  . PRO A 1 230 ? 17.51042  3.33498   -37.72377 1.000 14.66293 ? 311  PRO A CG  1 
ATOM   2412 C CD  . PRO A 1 230 ? 17.42712  2.03364   -36.98197 1.000 10.13019 ? 311  PRO A CD  1 
ATOM   2413 N N   . ILE A 1 231 ? 19.58570  3.23639   -33.99560 1.000 9.04732  ? 312  ILE A N   1 
ATOM   2414 C CA  . ILE A 1 231 ? 20.16822  3.63131   -32.71442 1.000 9.42650  ? 312  ILE A CA  1 
ATOM   2415 C C   . ILE A 1 231 ? 21.56956  3.08493   -32.51949 1.000 8.94705  ? 312  ILE A C   1 
ATOM   2416 O O   . ILE A 1 231 ? 22.29408  3.56840   -31.64824 1.000 9.47916  ? 312  ILE A O   1 
ATOM   2417 C CB  . ILE A 1 231 ? 19.28959  3.21200   -31.51634 1.000 10.07993 ? 312  ILE A CB  1 
ATOM   2418 C CG1 . ILE A 1 231 ? 19.23276  1.68198   -31.38932 1.000 9.60180  ? 312  ILE A CG1 1 
ATOM   2419 C CG2 . ILE A 1 231 ? 17.91650  3.84332   -31.61100 1.000 11.01650 ? 312  ILE A CG2 1 
ATOM   2420 C CD1 . ILE A 1 231 ? 18.12111  1.16824   -30.51139 1.000 10.39706 ? 312  ILE A CD1 1 
ATOM   2421 N N   . THR A 1 232 ? 21.96769  2.08592   -33.30161 1.000 8.88545  ? 313  THR A N   1 
ATOM   2422 C CA  . THR A 1 232 ? 23.21377  1.35999   -33.07589 1.000 8.42111  ? 313  THR A CA  1 
ATOM   2423 C C   . THR A 1 232 ? 24.40348  1.92823   -33.83171 1.000 8.44750  ? 313  THR A C   1 
ATOM   2424 O O   . THR A 1 232 ? 25.49151  1.36378   -33.73474 1.000 9.04016  ? 313  THR A O   1 
ATOM   2425 C CB  . THR A 1 232 ? 23.06245  -0.12706  -33.43519 1.000 8.62848  ? 313  THR A CB  1 
ATOM   2426 O OG1 . THR A 1 232 ? 22.90475  -0.27067  -34.84889 1.000 9.10879  ? 313  THR A OG1 1 
ATOM   2427 C CG2 . THR A 1 232 ? 21.89100  -0.75627  -32.71118 1.000 8.63038  ? 313  THR A CG2 1 
ATOM   2428 N N   . GLN A 1 233 ? 24.23563  3.02737   -34.56223 1.000 8.85165  ? 314  GLN A N   1 
ATOM   2429 C CA  . GLN A 1 233 ? 25.30453  3.52539   -35.41795 1.000 9.29319  ? 314  GLN A CA  1 
ATOM   2430 C C   . GLN A 1 233 ? 26.57846  3.76150   -34.62423 1.000 9.31074  ? 314  GLN A C   1 
ATOM   2431 O O   . GLN A 1 233 ? 26.55871  4.38913   -33.56453 1.000 9.45592  ? 314  GLN A O   1 
ATOM   2432 C CB  . GLN A 1 233 ? 24.88373  4.82465   -36.08430 1.000 10.29983 ? 314  GLN A CB  1 
ATOM   2433 C CG  . GLN A 1 233 ? 23.78923  4.68118   -37.09558 1.000 11.15850 ? 314  GLN A CG  1 
ATOM   2434 C CD  . GLN A 1 233 ? 23.26236  6.04058   -37.48878 1.000 11.36134 ? 314  GLN A CD  1 
ATOM   2435 O OE1 . GLN A 1 233 ? 23.94465  6.79955   -38.17521 1.000 13.89526 ? 314  GLN A OE1 1 
ATOM   2436 N NE2 . GLN A 1 233 ? 22.08840  6.40019   -36.97907 1.000 12.97322 ? 314  GLN A NE2 1 
ATOM   2437 N N   . GLY A 1 234 ? 27.69028  3.26829   -35.16341 1.000 9.69823  ? 315  GLY A N   1 
ATOM   2438 C CA  . GLY A 1 234 ? 28.97572  3.34020   -34.52271 1.000 9.14281  ? 315  GLY A CA  1 
ATOM   2439 C C   . GLY A 1 234 ? 29.39148  2.06137   -33.82691 1.000 8.52036  ? 315  GLY A C   1 
ATOM   2440 O O   . GLY A 1 234 ? 30.57998  1.89849   -33.53582 1.000 9.29996  ? 315  GLY A O   1 
ATOM   2441 N N   . ASN A 1 235 ? 28.43956  1.16690   -33.54172 1.000 8.24225  ? 316  ASN A N   1 
ATOM   2442 C CA  . ASN A 1 235 ? 28.69300  -0.08117  -32.83416 1.000 8.56631  ? 316  ASN A CA  1 
ATOM   2443 C C   . ASN A 1 235 ? 28.50296  -1.23721  -33.80403 1.000 8.94528  ? 316  ASN A C   1 
ATOM   2444 O O   . ASN A 1 235 ? 27.36571  -1.51138  -34.21613 1.000 9.22648  ? 316  ASN A O   1 
ATOM   2445 C CB  . ASN A 1 235 ? 27.72829  -0.22711  -31.65997 1.000 8.08539  ? 316  ASN A CB  1 
ATOM   2446 C CG  . ASN A 1 235 ? 28.08439  -1.39002  -30.75316 1.000 7.95680  ? 316  ASN A CG  1 
ATOM   2447 O OD1 . ASN A 1 235 ? 28.89967  -2.23429  -31.10152 1.000 8.63746  ? 316  ASN A OD1 1 
ATOM   2448 N ND2 . ASN A 1 235 ? 27.46661  -1.44475  -29.58670 1.000 7.93488  ? 316  ASN A ND2 1 
ATOM   2449 N N   . PRO A 1 236 ? 29.56240  -1.95190  -34.18161 1.000 9.15298  ? 317  PRO A N   1 
ATOM   2450 C CA  . PRO A 1 236 ? 29.37352  -3.11851  -35.05690 1.000 10.25693 ? 317  PRO A CA  1 
ATOM   2451 C C   . PRO A 1 236 ? 28.58103  -4.22682  -34.40112 1.000 8.91529  ? 317  PRO A C   1 
ATOM   2452 O O   . PRO A 1 236 ? 28.04592  -5.09290  -35.10451 1.000 10.54114 ? 317  PRO A O   1 
ATOM   2453 C CB  . PRO A 1 236 ? 30.80670  -3.56835  -35.36655 1.000 12.03249 ? 317  PRO A CB  1 
ATOM   2454 C CG  . PRO A 1 236 ? 31.60741  -3.05729  -34.23866 1.000 14.95597 ? 317  PRO A CG  1 
ATOM   2455 C CD  . PRO A 1 236 ? 30.97798  -1.74480  -33.84155 1.000 10.82654 ? 317  PRO A CD  1 
ATOM   2456 N N   . ASN A 1 237 ? 28.49501  -4.23480  -33.07156 1.000 8.56234  ? 318  ASN A N   1 
ATOM   2457 C CA  . ASN A 1 237 ? 27.72224  -5.24102  -32.35046 1.000 9.13063  ? 318  ASN A CA  1 
ATOM   2458 C C   . ASN A 1 237 ? 26.33095  -4.67585  -32.09075 1.000 8.22233  ? 318  ASN A C   1 
ATOM   2459 O O   . ASN A 1 237 ? 26.00754  -4.19460  -31.00314 1.000 9.04555  ? 318  ASN A O   1 
ATOM   2460 C CB  . ASN A 1 237 ? 28.46515  -5.65487  -31.08662 1.000 8.68348  ? 318  ASN A CB  1 
ATOM   2461 C CG  . ASN A 1 237 ? 29.80390  -6.28318  -31.41247 1.000 9.39499  ? 318  ASN A CG  1 
ATOM   2462 O OD1 . ASN A 1 237 ? 29.92219  -6.99302  -32.41267 1.000 10.42514 ? 318  ASN A OD1 1 
ATOM   2463 N ND2 . ASN A 1 237 ? 30.81698  -6.01577  -30.60384 1.000 9.92508  ? 318  ASN A ND2 1 
ATOM   2464 N N   . TYR A 1 238 ? 25.49232  -4.75794  -33.12604 1.000 8.95612  ? 319  TYR A N   1 
ATOM   2465 C CA  . TYR A 1 238 ? 24.20115  -4.07702  -33.15832 1.000 9.25326  ? 319  TYR A CA  1 
ATOM   2466 C C   . TYR A 1 238 ? 23.06202  -4.92632  -32.62107 1.000 8.72258  ? 319  TYR A C   1 
ATOM   2467 O O   . TYR A 1 238 ? 21.92731  -4.44316  -32.53706 1.000 9.63269  ? 319  TYR A O   1 
ATOM   2468 C CB  . TYR A 1 238 ? 23.88359  -3.56494  -34.57123 1.000 9.97067  ? 319  TYR A CB  1 
ATOM   2469 C CG  . TYR A 1 238 ? 23.97003  -4.61339  -35.65204 1.000 10.84709 ? 319  TYR A CG  1 
ATOM   2470 C CD1 . TYR A 1 238 ? 22.90639  -5.46600  -35.90093 1.000 11.86566 ? 319  TYR A CD1 1 
ATOM   2471 C CD2 . TYR A 1 238 ? 25.10507  -4.73851  -36.43913 1.000 12.73700 ? 319  TYR A CD2 1 
ATOM   2472 C CE1 . TYR A 1 238 ? 22.97521  -6.43101  -36.89110 1.000 12.28194 ? 319  TYR A CE1 1 
ATOM   2473 C CE2 . TYR A 1 238 ? 25.18314  -5.69861  -37.43465 1.000 14.14852 ? 319  TYR A CE2 1 
ATOM   2474 C CZ  . TYR A 1 238 ? 24.11826  -6.54083  -37.65453 1.000 13.25261 ? 319  TYR A CZ  1 
ATOM   2475 O OH  . TYR A 1 238 ? 24.18173  -7.49156  -38.64589 1.000 16.99780 ? 319  TYR A OH  1 
ATOM   2476 N N   . ASP A 1 239 ? 23.33990  -6.16903  -32.24724 1.000 8.20706  ? 320  ASP A N   1 
ATOM   2477 C CA  . ASP A 1 239 ? 22.33601  -7.04831  -31.67339 1.000 8.63469  ? 320  ASP A CA  1 
ATOM   2478 C C   . ASP A 1 239 ? 23.00918  -7.96125  -30.65566 1.000 7.68720  ? 320  ASP A C   1 
ATOM   2479 O O   . ASP A 1 239 ? 24.23114  -7.95482  -30.48980 1.000 7.86858  ? 320  ASP A O   1 
ATOM   2480 C CB  . ASP A 1 239 ? 21.55289  -7.80988  -32.75989 1.000 9.36788  ? 320  ASP A CB  1 
ATOM   2481 C CG  . ASP A 1 239 ? 22.44849  -8.63780  -33.67163 1.000 9.73422  ? 320  ASP A CG  1 
ATOM   2482 O OD1 . ASP A 1 239 ? 23.60373  -8.91700  -33.28352 1.000 9.66102  ? 320  ASP A OD1 1 
ATOM   2483 O OD2 . ASP A 1 239 ? 21.97500  -9.01314  -34.76900 1.000 10.86716 ? 320  ASP A OD2 1 
ATOM   2484 N N   . GLU A 1 240 ? 22.19413  -8.74684  -29.94992 1.000 7.73515  ? 321  GLU A N   1 
ATOM   2485 C CA  . GLU A 1 240 ? 22.75425  -9.53017  -28.85248 1.000 7.27239  ? 321  GLU A CA  1 
ATOM   2486 C C   . GLU A 1 240 ? 23.67173  -10.63938 -29.34497 1.000 7.74597  ? 321  GLU A C   1 
ATOM   2487 O O   . GLU A 1 240 ? 24.65276  -10.95480 -28.67179 1.000 8.22172  ? 321  GLU A O   1 
ATOM   2488 C CB  . GLU A 1 240 ? 21.65869  -10.07342 -27.93661 1.000 7.59566  ? 321  GLU A CB  1 
ATOM   2489 C CG  . GLU A 1 240 ? 20.86799  -8.98317  -27.22350 1.000 7.60464  ? 321  GLU A CG  1 
ATOM   2490 C CD  . GLU A 1 240 ? 21.75570  -8.06899  -26.40190 1.000 6.58337  ? 321  GLU A CD  1 
ATOM   2491 O OE1 . GLU A 1 240 ? 22.30834  -8.53942  -25.39295 1.000 8.70544  ? 321  GLU A OE1 1 
ATOM   2492 O OE2 . GLU A 1 240 ? 21.91079  -6.88742  -26.78480 1.000 8.32894  ? 321  GLU A OE2 1 
ATOM   2493 N N   . ILE A 1 241 ? 23.38909  -11.23741 -30.50786 1.000 8.09293  ? 322  ILE A N   1 
ATOM   2494 C CA  . ILE A 1 241 ? 24.26207  -12.30996 -30.98083 1.000 8.68704  ? 322  ILE A CA  1 
ATOM   2495 C C   . ILE A 1 241 ? 25.65769  -11.77957 -31.28982 1.000 8.68427  ? 322  ILE A C   1 
ATOM   2496 O O   . ILE A 1 241 ? 26.65725  -12.43754 -30.99645 1.000 8.88955  ? 322  ILE A O   1 
ATOM   2497 C CB  . ILE A 1 241 ? 23.63961  -13.10596 -32.14753 1.000 9.49763  ? 322  ILE A CB  1 
ATOM   2498 C CG1 . ILE A 1 241 ? 24.38850  -14.41861 -32.36932 1.000 11.69952 ? 322  ILE A CG1 1 
ATOM   2499 C CG2 . ILE A 1 241 ? 23.62687  -12.31210 -33.44546 1.000 10.96305 ? 322  ILE A CG2 1 
ATOM   2500 C CD1 . ILE A 1 241 ? 24.40702  -15.32990 -31.18838 1.000 14.03431 ? 322  ILE A CD1 1 
ATOM   2501 N N   . HIS A 1 242 ? 25.75575  -10.57585 -31.86120 1.000 8.33803  ? 323  HIS A N   1 
ATOM   2502 C CA  . HIS A 1 242 ? 27.07858  -10.00020 -32.08970 1.000 9.07620  ? 323  HIS A CA  1 
ATOM   2503 C C   . HIS A 1 242 ? 27.80595  -9.76814  -30.76971 1.000 8.12087  ? 323  HIS A C   1 
ATOM   2504 O O   . HIS A 1 242 ? 29.00137  -10.05099 -30.64853 1.000 9.32729  ? 323  HIS A O   1 
ATOM   2505 C CB  . HIS A 1 242 ? 26.97321  -8.67970  -32.84577 1.000 9.28164  ? 323  HIS A CB  1 
ATOM   2506 C CG  . HIS A 1 242 ? 26.84933  -8.81925  -34.32707 1.000 10.39181 ? 323  HIS A CG  1 
ATOM   2507 N ND1 . HIS A 1 242 ? 25.65350  -9.09170  -34.95468 1.000 11.27598 ? 323  HIS A ND1 1 
ATOM   2508 C CD2 . HIS A 1 242 ? 27.76549  -8.66632  -35.31188 1.000 13.24867 ? 323  HIS A CD2 1 
ATOM   2509 C CE1 . HIS A 1 242 ? 25.84418  -9.12770  -36.26187 1.000 12.77239 ? 323  HIS A CE1 1 
ATOM   2510 N NE2 . HIS A 1 242 ? 27.11785  -8.87703  -36.50442 1.000 14.75014 ? 323  HIS A NE2 1 
ATOM   2511 N N   . TYR A 1 243 ? 27.10613  -9.20620  -29.78132 1.000 7.94416  ? 324  TYR A N   1 
ATOM   2512 C CA  . TYR A 1 243 ? 27.70202  -8.95707  -28.46963 1.000 8.00831  ? 324  TYR A CA  1 
ATOM   2513 C C   . TYR A 1 243 ? 28.22474  -10.25041 -27.84997 1.000 8.03490  ? 324  TYR A C   1 
ATOM   2514 O O   . TYR A 1 243 ? 29.38032  -10.33198 -27.43169 1.000 8.29350  ? 324  TYR A O   1 
ATOM   2515 C CB  . TYR A 1 243 ? 26.63929  -8.29436  -27.58845 1.000 8.10768  ? 324  TYR A CB  1 
ATOM   2516 C CG  . TYR A 1 243 ? 26.94513  -8.17368  -26.11160 1.000 7.95913  ? 324  TYR A CG  1 
ATOM   2517 C CD1 . TYR A 1 243 ? 28.23722  -7.97998  -25.64245 1.000 8.14845  ? 324  TYR A CD1 1 
ATOM   2518 C CD2 . TYR A 1 243 ? 25.91434  -8.21373  -25.18288 1.000 7.74299  ? 324  TYR A CD2 1 
ATOM   2519 C CE1 . TYR A 1 243 ? 28.49823  -7.85349  -24.28091 1.000 7.73929  ? 324  TYR A CE1 1 
ATOM   2520 C CE2 . TYR A 1 243 ? 26.16355  -8.08450  -23.82215 1.000 7.61727  ? 324  TYR A CE2 1 
ATOM   2521 C CZ  . TYR A 1 243 ? 27.45798  -7.91759  -23.37609 1.000 7.07769  ? 324  TYR A CZ  1 
ATOM   2522 O OH  . TYR A 1 243 ? 27.75952  -7.81439  -22.03777 1.000 8.02496  ? 324  TYR A OH  1 
ATOM   2523 N N   A ILE A 1 244 ? 27.38653  -11.28074 -27.82606 0.775 7.96070  ? 325  ILE A N   1 
ATOM   2524 N N   B ILE A 1 244 ? 27.36934  -11.26749 -27.75992 0.225 7.96084  ? 325  ILE A N   1 
ATOM   2525 C CA  A ILE A 1 244 ? 27.73687  -12.54449 -27.19586 0.775 8.02722  ? 325  ILE A CA  1 
ATOM   2526 C CA  B ILE A 1 244 ? 27.75900  -12.50193 -27.08970 0.225 8.32859  ? 325  ILE A CA  1 
ATOM   2527 C C   A ILE A 1 244 ? 28.89300  -13.21924 -27.92272 0.775 8.08268  ? 325  ILE A C   1 
ATOM   2528 C C   B ILE A 1 244 ? 28.85015  -13.21491 -27.87628 0.225 8.08065  ? 325  ILE A C   1 
ATOM   2529 O O   A ILE A 1 244 ? 29.81883  -13.74724 -27.29670 0.775 8.85682  ? 325  ILE A O   1 
ATOM   2530 O O   B ILE A 1 244 ? 29.84417  -13.68227 -27.30665 0.225 8.80288  ? 325  ILE A O   1 
ATOM   2531 C CB  A ILE A 1 244 ? 26.47422  -13.41487 -27.08552 0.775 7.96107  ? 325  ILE A CB  1 
ATOM   2532 C CB  B ILE A 1 244 ? 26.52639  -13.38971 -26.84651 0.225 8.30313  ? 325  ILE A CB  1 
ATOM   2533 C CG1 A ILE A 1 244 ? 25.52490  -12.77657 -26.05878 0.775 7.41498  ? 325  ILE A CG1 1 
ATOM   2534 C CG1 B ILE A 1 244 ? 25.68782  -12.82370 -25.69946 0.225 9.61351  ? 325  ILE A CG1 1 
ATOM   2535 C CG2 A ILE A 1 244 ? 26.81820  -14.83961 -26.72281 0.775 8.65301  ? 325  ILE A CG2 1 
ATOM   2536 C CG2 B ILE A 1 244 ? 26.94640  -14.80774 -26.52181 0.225 9.01670  ? 325  ILE A CG2 1 
ATOM   2537 C CD1 A ILE A 1 244 ? 24.15078  -13.33680 -26.05114 0.775 8.34419  ? 325  ILE A CD1 1 
ATOM   2538 C CD1 B ILE A 1 244 ? 24.27974  -12.46415 -26.08381 0.225 15.62675 ? 325  ILE A CD1 1 
ATOM   2539 N N   A ASN A 1 245 ? 28.87912  -13.19082 -29.25327 0.775 8.17676  ? 326  ASN A N   1 
ATOM   2540 N N   B ASN A 1 245 ? 28.69449  -13.29438 -29.20102 0.225 8.73010  ? 326  ASN A N   1 
ATOM   2541 C CA  A ASN A 1 245 ? 29.95700  -13.81273 -30.01384 0.775 8.69070  ? 326  ASN A CA  1 
ATOM   2542 C CA  B ASN A 1 245 ? 29.73129  -13.90788 -30.02593 0.225 8.88289  ? 326  ASN A CA  1 
ATOM   2543 C C   A ASN A 1 245 ? 31.28816  -13.14635 -29.70421 0.775 8.75888  ? 326  ASN A C   1 
ATOM   2544 C C   B ASN A 1 245 ? 31.02950  -13.11511 -29.97967 0.225 8.71118  ? 326  ASN A C   1 
ATOM   2545 O O   A ASN A 1 245 ? 32.33505  -13.80778 -29.70685 0.775 9.21444  ? 326  ASN A O   1 
ATOM   2546 O O   B ASN A 1 245 ? 32.10178  -13.67354 -30.24278 0.225 7.99815  ? 326  ASN A O   1 
ATOM   2547 C CB  A ASN A 1 245 ? 29.66272  -13.71825 -31.51576 0.775 8.94047  ? 326  ASN A CB  1 
ATOM   2548 C CB  B ASN A 1 245 ? 29.25177  -14.07585 -31.46685 0.225 11.78701 ? 326  ASN A CB  1 
ATOM   2549 C CG  A ASN A 1 245 ? 28.60293  -14.71727 -31.98502 0.775 8.91748  ? 326  ASN A CG  1 
ATOM   2550 C CG  B ASN A 1 245 ? 28.11611  -15.06738 -31.58689 0.225 14.15424 ? 326  ASN A CG  1 
ATOM   2551 O OD1 A ASN A 1 245 ? 28.25238  -15.66399 -31.28032 0.775 10.22039 ? 326  ASN A OD1 1 
ATOM   2552 O OD1 B ASN A 1 245 ? 27.62976  -15.59449 -30.58697 0.225 17.85606 ? 326  ASN A OD1 1 
ATOM   2553 N ND2 A ASN A 1 245 ? 28.09414  -14.50323 -33.19769 0.775 10.79193 ? 326  ASN A ND2 1 
ATOM   2554 N ND2 B ASN A 1 245 ? 27.68220  -15.32123 -32.81303 0.225 15.83111 ? 326  ASN A ND2 1 
ATOM   2555 N N   A ALA A 1 246 ? 31.26152  -11.84216 -29.44105 0.775 8.19509  ? 327  ALA A N   1 
ATOM   2556 N N   B ALA A 1 246 ? 30.95367  -11.82056 -29.66186 0.225 7.95725  ? 327  ALA A N   1 
ATOM   2557 C CA  A ALA A 1 246 ? 32.47599  -11.08816 -29.18347 0.775 9.72693  ? 327  ALA A CA  1 
ATOM   2558 C CA  B ALA A 1 246 ? 32.12567  -10.98339 -29.43927 0.225 8.43749  ? 327  ALA A CA  1 
ATOM   2559 C C   A ALA A 1 246 ? 32.96048  -11.26436 -27.75256 0.775 8.06260  ? 327  ALA A C   1 
ATOM   2560 C C   B ALA A 1 246 ? 32.45933  -10.81476 -27.96241 0.225 12.89268 ? 327  ALA A C   1 
ATOM   2561 O O   A ALA A 1 246 ? 34.16772  -11.32139 -27.52601 0.775 9.78611  ? 327  ALA A O   1 
ATOM   2562 O O   B ALA A 1 246 ? 33.35691  -10.03584 -27.62891 0.225 14.90346 ? 327  ALA A O   1 
ATOM   2563 C CB  A ALA A 1 246 ? 32.24097  -9.60881  -29.48224 0.775 9.25215  ? 327  ALA A CB  1 
ATOM   2564 C CB  B ALA A 1 246 ? 31.93871  -9.60123  -30.07298 0.225 8.20196  ? 327  ALA A CB  1 
ATOM   2565 N N   A LEU A 1 247 ? 32.04770  -11.33787 -26.77583 0.775 8.34403  ? 328  LEU A N   1 
ATOM   2566 N N   B LEU A 1 247 ? 31.74049  -11.49017 -27.07357 0.225 8.07122  ? 328  LEU A N   1 
ATOM   2567 C CA  A LEU A 1 247 ? 32.44694  -11.41247 -25.37115 0.775 8.13825  ? 328  LEU A CA  1 
ATOM   2568 C CA  B LEU A 1 247 ? 32.08030  -11.51443 -25.66261 0.225 8.94088  ? 328  LEU A CA  1 
ATOM   2569 C C   A LEU A 1 247 ? 32.84363  -12.82346 -24.95081 0.775 8.49657  ? 328  LEU A C   1 
ATOM   2570 C C   B LEU A 1 247 ? 32.36380  -12.90884 -25.13269 0.225 10.01978 ? 328  LEU A C   1 
ATOM   2571 O O   A LEU A 1 247 ? 33.79763  -13.00330 -24.19367 0.775 9.07560  ? 328  LEU A O   1 
ATOM   2572 O O   B LEU A 1 247 ? 33.13101  -13.04925 -24.17857 0.225 12.29972 ? 328  LEU A O   1 
ATOM   2573 C CB  A LEU A 1 247 ? 31.30607  -10.90832 -24.48745 0.775 7.60245  ? 328  LEU A CB  1 
ATOM   2574 C CB  B LEU A 1 247 ? 30.94993  -10.89926 -24.81812 0.225 7.79571  ? 328  LEU A CB  1 
ATOM   2575 C CG  A LEU A 1 247 ? 31.57646  -10.91879 -22.98723 0.775 7.75701  ? 328  LEU A CG  1 
ATOM   2576 C CG  B LEU A 1 247 ? 31.21795  -10.55907 -23.35139 0.225 11.62138 ? 328  LEU A CG  1 
ATOM   2577 C CD1 A LEU A 1 247 ? 32.75296  -10.03260 -22.67927 0.775 10.93218 ? 328  LEU A CD1 1 
ATOM   2578 C CD1 B LEU A 1 247 ? 31.84366  -9.17534  -23.21863 0.225 14.84398 ? 328  LEU A CD1 1 
ATOM   2579 C CD2 A LEU A 1 247 ? 30.37522  -10.44330 -22.21330 0.775 7.97846  ? 328  LEU A CD2 1 
ATOM   2580 C CD2 B LEU A 1 247 ? 29.92568  -10.63319 -22.56385 0.225 8.35849  ? 328  LEU A CD2 1 
ATOM   2581 N N   A ALA A 1 248 ? 32.10256  -13.82820 -25.39086 0.775 8.49282  ? 329  ALA A N   1 
ATOM   2582 N N   B ALA A 1 248 ? 31.76554  -13.94037 -25.72103 0.225 9.16052  ? 329  ALA A N   1 
ATOM   2583 C CA  A ALA A 1 248 ? 32.34161  -15.20073 -24.93866 0.775 9.46430  ? 329  ALA A CA  1 
ATOM   2584 C CA  B ALA A 1 248 ? 31.94959  -15.29086 -25.19121 0.225 9.76992  ? 329  ALA A CA  1 
ATOM   2585 C C   A ALA A 1 248 ? 33.79894  -15.64644 -25.01427 0.775 9.98028  ? 329  ALA A C   1 
ATOM   2586 C C   B ALA A 1 248 ? 33.37102  -15.81937 -25.35346 0.225 9.46402  ? 329  ALA A C   1 
ATOM   2587 O O   A ALA A 1 248 ? 34.29651  -16.20576 -24.02470 0.775 10.83656 ? 329  ALA A O   1 
ATOM   2588 O O   B ALA A 1 248 ? 33.89686  -16.40694 -24.39124 0.225 9.75537  ? 329  ALA A O   1 
ATOM   2589 C CB  A ALA A 1 248 ? 31.39475  -16.16178 -25.66711 0.775 10.30023 ? 329  ALA A CB  1 
ATOM   2590 C CB  B ALA A 1 248 ? 30.87263  -16.22787 -25.74256 0.225 10.99257 ? 329  ALA A CB  1 
ATOM   2591 N N   A PRO A 1 249 ? 34.52999  -15.44174 -26.11505 0.775 9.83371  ? 330  PRO A N   1 
ATOM   2592 N N   B PRO A 1 249 ? 34.05191  -15.65963 -26.49842 0.225 9.59776  ? 330  PRO A N   1 
ATOM   2593 C CA  A PRO A 1 249 ? 35.92353  -15.91658 -26.14885 0.775 11.02018 ? 330  PRO A CA  1 
ATOM   2594 C CA  B PRO A 1 249 ? 35.43127  -16.17624 -26.57977 0.225 10.24879 ? 330  PRO A CA  1 
ATOM   2595 C C   A PRO A 1 249 ? 36.81895  -15.24910 -25.12551 0.775 10.22726 ? 330  PRO A C   1 
ATOM   2596 C C   B PRO A 1 249 ? 36.41911  -15.43455 -25.69703 0.225 8.38124  ? 330  PRO A C   1 
ATOM   2597 O O   A PRO A 1 249 ? 37.81142  -15.85321 -24.69744 0.775 11.47715 ? 330  PRO A O   1 
ATOM   2598 O O   B PRO A 1 249 ? 37.42771  -16.02771 -25.29417 0.225 10.47185 ? 330  PRO A O   1 
ATOM   2599 C CB  A PRO A 1 249 ? 36.37092  -15.62201 -27.58771 0.775 13.12870 ? 330  PRO A CB  1 
ATOM   2600 C CB  B PRO A 1 249 ? 35.78139  -16.04116 -28.06685 0.225 12.36957 ? 330  PRO A CB  1 
ATOM   2601 C CG  A PRO A 1 249 ? 35.11489  -15.49746 -28.36283 0.775 14.96581 ? 330  PRO A CG  1 
ATOM   2602 C CG  B PRO A 1 249 ? 34.91346  -14.95150 -28.56079 0.225 13.14447 ? 330  PRO A CG  1 
ATOM   2603 C CD  A PRO A 1 249 ? 34.10713  -14.91884 -27.42408 0.775 11.41583 ? 330  PRO A CD  1 
ATOM   2604 C CD  B PRO A 1 249 ? 33.62492  -15.06573 -27.78144 0.225 9.25761  ? 330  PRO A CD  1 
ATOM   2605 N N   A LEU A 1 250 ? 36.50840  -14.01831 -24.72570 0.775 9.86404  ? 331  LEU A N   1 
ATOM   2606 N N   B LEU A 1 250 ? 36.17411  -14.15310 -25.40028 0.225 7.64952  ? 331  LEU A N   1 
ATOM   2607 C CA  A LEU A 1 250 ? 37.31715  -13.35730 -23.71158 0.775 10.27618 ? 331  LEU A CA  1 
ATOM   2608 C CA  B LEU A 1 250 ? 37.02601  -13.43261 -24.45832 0.225 7.34661  ? 331  LEU A CA  1 
ATOM   2609 C C   A LEU A 1 250 ? 37.16294  -14.05601 -22.36703 0.775 10.57081 ? 331  LEU A C   1 
ATOM   2610 C C   B LEU A 1 250 ? 36.95084  -14.06575 -23.07780 0.225 9.96173  ? 331  LEU A C   1 
ATOM   2611 O O   A LEU A 1 250 ? 38.13697  -14.20905 -21.62235 0.775 12.80724 ? 331  LEU A O   1 
ATOM   2612 O O   B LEU A 1 250 ? 37.96345  -14.18224 -22.37629 0.225 12.96727 ? 331  LEU A O   1 
ATOM   2613 C CB  A LEU A 1 250 ? 36.93140  -11.87878 -23.63233 0.775 10.51266 ? 331  LEU A CB  1 
ATOM   2614 C CB  B LEU A 1 250 ? 36.58592  -11.97195 -24.38698 0.225 8.67544  ? 331  LEU A CB  1 
ATOM   2615 C CG  A LEU A 1 250 ? 36.92129  -11.11815 -24.96388 0.775 11.52657 ? 331  LEU A CG  1 
ATOM   2616 C CG  B LEU A 1 250 ? 36.62811  -11.17988 -25.69419 0.225 11.16074 ? 331  LEU A CG  1 
ATOM   2617 C CD1 A LEU A 1 250 ? 36.53432  -9.66767  -24.75028 0.775 12.93658 ? 331  LEU A CD1 1 
ATOM   2618 C CD1 B LEU A 1 250 ? 36.38854  -9.70040  -25.43188 0.225 10.73252 ? 331  LEU A CD1 1 
ATOM   2619 C CD2 A LEU A 1 250 ? 38.27664  -11.22647 -25.65695 0.775 15.12417 ? 331  LEU A CD2 1 
ATOM   2620 C CD2 B LEU A 1 250 ? 37.95728  -11.39565 -26.39426 0.225 12.38960 ? 331  LEU A CD2 1 
ATOM   2621 N N   A LEU A 1 251 ? 35.94858  -14.51587 -22.05530 0.775 9.97758  ? 332  LEU A N   1 
ATOM   2622 N N   B LEU A 1 251 ? 35.75047  -14.48451 -22.67796 0.225 9.60254  ? 332  LEU A N   1 
ATOM   2623 C CA  A LEU A 1 251 ? 35.72592  -15.27105 -20.82651 0.775 9.39257  ? 332  LEU A CA  1 
ATOM   2624 C CA  B LEU A 1 251 ? 35.57596  -15.18178 -21.41202 0.225 9.20601  ? 332  LEU A CA  1 
ATOM   2625 C C   A LEU A 1 251 ? 36.35047  -16.66179 -20.90911 0.775 10.12127 ? 332  LEU A C   1 
ATOM   2626 C C   B LEU A 1 251 ? 36.27330  -16.53773 -21.43902 0.225 10.47800 ? 332  LEU A C   1 
ATOM   2627 O O   A LEU A 1 251 ? 36.96080  -17.13665 -19.94266 0.775 10.56413 ? 332  LEU A O   1 
ATOM   2628 O O   B LEU A 1 251 ? 36.96576  -16.90936 -20.48271 0.225 11.32765 ? 332  LEU A O   1 
ATOM   2629 C CB  A LEU A 1 251 ? 34.22762  -15.36647 -20.55091 0.775 8.93921  ? 332  LEU A CB  1 
ATOM   2630 C CB  B LEU A 1 251 ? 34.07966  -15.35047 -21.14835 0.225 7.56978  ? 332  LEU A CB  1 
ATOM   2631 C CG  A LEU A 1 251 ? 33.47726  -14.03366 -20.51826 0.775 9.05824  ? 332  LEU A CG  1 
ATOM   2632 C CG  B LEU A 1 251 ? 33.23744  -14.06928 -21.05611 0.225 8.87349  ? 332  LEU A CG  1 
ATOM   2633 C CD1 A LEU A 1 251 ? 31.98399  -14.27513 -20.39104 0.775 12.08613 ? 332  LEU A CD1 1 
ATOM   2634 C CD1 B LEU A 1 251 ? 31.79426  -14.41352 -20.73627 0.225 10.05795 ? 332  LEU A CD1 1 
ATOM   2635 C CD2 A LEU A 1 251 ? 33.98476  -13.16944 -19.38329 0.775 10.13568 ? 332  LEU A CD2 1 
ATOM   2636 C CD2 B LEU A 1 251 ? 33.79052  -13.09029 -20.02988 0.225 10.77753 ? 332  LEU A CD2 1 
ATOM   2637 N N   A GLN A 1 252 ? 36.23240  -17.32127 -22.06683 0.775 10.55557 ? 333  GLN A N   1 
ATOM   2638 N N   B GLN A 1 252 ? 36.11118  -17.28500 -22.53601 0.225 10.01658 ? 333  GLN A N   1 
ATOM   2639 C CA  A GLN A 1 252 ? 36.86332  -18.62618 -22.25840 0.775 11.84780 ? 333  GLN A CA  1 
ATOM   2640 C CA  B GLN A 1 252 ? 36.77512  -18.57651 -22.67411 0.225 12.28323 ? 333  GLN A CA  1 
ATOM   2641 C C   A GLN A 1 252 ? 38.36005  -18.57911 -21.96557 0.775 11.98419 ? 333  GLN A C   1 
ATOM   2642 C C   B GLN A 1 252 ? 38.29099  -18.41913 -22.68532 0.225 10.74306 ? 333  GLN A C   1 
ATOM   2643 O O   A GLN A 1 252 ? 38.90466  -19.50050 -21.34706 0.775 11.48300 ? 333  GLN A O   1 
ATOM   2644 O O   B GLN A 1 252 ? 39.01336  -19.27493 -22.15913 0.225 11.32973 ? 333  GLN A O   1 
ATOM   2645 C CB  A GLN A 1 252 ? 36.62816  -19.11917 -23.68842 0.775 12.99218 ? 333  GLN A CB  1 
ATOM   2646 C CB  B GLN A 1 252 ? 36.28348  -19.24664 -23.95820 0.225 13.56638 ? 333  GLN A CB  1 
ATOM   2647 C CG  A GLN A 1 252 ? 35.19277  -19.50557 -24.00468 0.775 13.30288 ? 333  GLN A CG  1 
ATOM   2648 C CG  B GLN A 1 252 ? 34.81135  -19.64718 -23.90400 0.225 15.22203 ? 333  GLN A CG  1 
ATOM   2649 C CD  A GLN A 1 252 ? 34.98757  -19.89504 -25.46494 0.775 13.46494 ? 333  GLN A CD  1 
ATOM   2650 C CD  B GLN A 1 252 ? 34.26204  -20.05089 -25.25971 0.225 15.61788 ? 333  GLN A CD  1 
ATOM   2651 O OE1 A GLN A 1 252 ? 35.59522  -19.31907 -26.36839 0.775 16.95679 ? 333  GLN A OE1 1 
ATOM   2652 O OE1 B GLN A 1 252 ? 34.82221  -19.69613 -26.29642 0.225 16.50655 ? 333  GLN A OE1 1 
ATOM   2653 N NE2 A GLN A 1 252 ? 34.12812  -20.88153 -25.69866 0.775 16.23479 ? 333  GLN A NE2 1 
ATOM   2654 N NE2 B GLN A 1 252 ? 33.15304  -20.78346 -25.25891 0.225 16.45721 ? 333  GLN A NE2 1 
ATOM   2655 N N   A GLN A 1 253 ? 39.04431  -17.51986 -22.41164 0.775 11.90643 ? 334  GLN A N   1 
ATOM   2656 N N   B GLN A 1 253 ? 38.78776  -17.32428 -23.26543 0.225 11.51922 ? 334  GLN A N   1 
ATOM   2657 C CA  A GLN A 1 253 ? 40.48559  -17.39788 -22.19835 0.775 14.61467 ? 334  GLN A CA  1 
ATOM   2658 C CA  B GLN A 1 253 ? 40.21561  -17.03011 -23.26220 0.225 15.41367 ? 334  GLN A CA  1 
ATOM   2659 C C   A GLN A 1 253 ? 40.84587  -17.41443 -20.72208 0.775 13.42702 ? 334  GLN A C   1 
ATOM   2660 C C   B GLN A 1 253 ? 40.73611  -16.74200 -21.85981 0.225 14.16681 ? 334  GLN A C   1 
ATOM   2661 O O   A GLN A 1 253 ? 41.94465  -17.85231 -20.35554 0.775 13.06955 ? 334  GLN A O   1 
ATOM   2662 O O   B GLN A 1 253 ? 41.93321  -16.91207 -21.60773 0.225 16.03646 ? 334  GLN A O   1 
ATOM   2663 C CB  A GLN A 1 253 ? 40.98782  -16.08433 -22.79194 0.775 15.67451 ? 334  GLN A CB  1 
ATOM   2664 C CB  B GLN A 1 253 ? 40.46679  -15.83762 -24.18608 0.225 18.06028 ? 334  GLN A CB  1 
ATOM   2665 C CG  A GLN A 1 253 ? 41.02401  -16.01154 -24.30030 0.775 22.55759 ? 334  GLN A CG  1 
ATOM   2666 C CG  B GLN A 1 253 ? 41.30482  -16.15129 -25.41336 0.225 20.01446 ? 334  GLN A CG  1 
ATOM   2667 C CD  A GLN A 1 253 ? 41.91606  -14.88068 -24.78420 0.775 24.49190 ? 334  GLN A CD  1 
ATOM   2668 C CD  B GLN A 1 253 ? 41.49291  -14.94016 -26.30532 0.225 20.71540 ? 334  GLN A CD  1 
ATOM   2669 O OE1 A GLN A 1 253 ? 41.65331  -13.70747 -24.50914 0.775 28.32513 ? 334  GLN A OE1 1 
ATOM   2670 O OE1 B GLN A 1 253 ? 40.62666  -14.62306 -27.12125 0.225 20.29181 ? 334  GLN A OE1 1 
ATOM   2671 N NE2 A GLN A 1 253 ? 42.98078  -15.22784 -25.49885 0.775 24.47862 ? 334  GLN A NE2 1 
ATOM   2672 N NE2 B GLN A 1 253 ? 42.61964  -14.25532 -26.15414 0.225 20.13323 ? 334  GLN A NE2 1 
ATOM   2673 N N   A ALA A 1 254 ? 39.95531  -16.91604 -19.86833 0.775 13.90868 ? 335  ALA A N   1 
ATOM   2674 N N   B ALA A 1 254 ? 39.86241  -16.31844 -20.94611 0.225 12.19538 ? 335  ALA A N   1 
ATOM   2675 C CA  A ALA A 1 254 ? 40.18537  -16.87782 -18.43232 0.775 14.69990 ? 335  ALA A CA  1 
ATOM   2676 C CA  B ALA A 1 254 ? 40.23195  -16.06269 -19.56122 0.225 16.31909 ? 335  ALA A CA  1 
ATOM   2677 C C   A ALA A 1 254 ? 39.94708  -18.22288 -17.76011 0.775 14.07301 ? 335  ALA A C   1 
ATOM   2678 C C   B ALA A 1 254 ? 40.05567  -17.27888 -18.66116 0.225 15.51809 ? 335  ALA A C   1 
ATOM   2679 O O   A ALA A 1 254 ? 40.15312  -18.33760 -16.54588 0.775 16.17576 ? 335  ALA A O   1 
ATOM   2680 O O   B ALA A 1 254 ? 40.43498  -17.21966 -17.48669 0.225 15.58520 ? 335  ALA A O   1 
ATOM   2681 C CB  A ALA A 1 254 ? 39.28250  -15.82039 -17.79452 0.775 16.58513 ? 335  ALA A CB  1 
ATOM   2682 C CB  B ALA A 1 254 ? 39.42498  -14.88634 -19.00151 0.225 15.99914 ? 335  ALA A CB  1 
ATOM   2683 N N   A GLY A 1 255 ? 39.51865  -19.23118 -18.51016 0.775 10.90888 ? 336  GLY A N   1 
ATOM   2684 N N   B GLY A 1 255 ? 39.47974  -18.36515 -19.16877 0.225 14.34593 ? 336  GLY A N   1 
ATOM   2685 C CA  A GLY A 1 255 ? 39.16132  -20.51651 -17.94106 0.775 12.59561 ? 336  GLY A CA  1 
ATOM   2686 C CA  B GLY A 1 255 ? 39.40633  -19.60984 -18.43511 0.225 12.40217 ? 336  GLY A CA  1 
ATOM   2687 C C   A GLY A 1 255 ? 37.69574  -20.67924 -17.61186 0.775 10.09346 ? 336  GLY A C   1 
ATOM   2688 C C   B GLY A 1 255 ? 38.04470  -20.02287 -17.91082 0.225 8.24203  ? 336  GLY A C   1 
ATOM   2689 O O   A GLY A 1 255 ? 37.32517  -21.66796 -16.96977 0.775 12.58344 ? 336  GLY A O   1 
ATOM   2690 O O   B GLY A 1 255 ? 37.97512  -20.97287 -17.12310 0.225 13.58743 ? 336  GLY A O   1 
ATOM   2691 N N   A TRP A 1 256 ? 36.85346  -19.74529 -18.04292 0.775 11.10526 ? 337  TRP A N   1 
ATOM   2692 N N   B TRP A 1 256 ? 36.95954  -19.36481 -18.31179 0.225 12.01636 ? 337  TRP A N   1 
ATOM   2693 C CA  A TRP A 1 256 ? 35.42043  -19.73669 -17.78707 0.775 10.59922 ? 337  TRP A CA  1 
ATOM   2694 C CA  B TRP A 1 256 ? 35.63096  -19.77151 -17.85924 0.225 11.85125 ? 337  TRP A CA  1 
ATOM   2695 C C   A TRP A 1 256 ? 34.75067  -19.89399 -19.14401 0.775 11.60074 ? 337  TRP A C   1 
ATOM   2696 C C   B TRP A 1 256 ? 34.69458  -20.03902 -19.02821 0.225 10.55022 ? 337  TRP A C   1 
ATOM   2697 O O   A TRP A 1 256 ? 34.60073  -18.92692 -19.89634 0.775 13.17885 ? 337  TRP A O   1 
ATOM   2698 O O   B TRP A 1 256 ? 34.44995  -19.15175 -19.84977 0.225 9.28298  ? 337  TRP A O   1 
ATOM   2699 C CB  A TRP A 1 256 ? 35.02019  -18.42439 -17.15784 0.775 8.34290  ? 337  TRP A CB  1 
ATOM   2700 C CB  B TRP A 1 256 ? 35.05380  -18.83972 -16.78021 0.225 13.34987 ? 337  TRP A CB  1 
ATOM   2701 C CG  A TRP A 1 256 ? 33.58675  -18.35417 -16.70211 0.775 7.33121  ? 337  TRP A CG  1 
ATOM   2702 C CG  B TRP A 1 256 ? 34.56087  -17.49136 -17.17840 0.225 14.36473 ? 337  TRP A CG  1 
ATOM   2703 C CD1 A TRP A 1 256 ? 32.69420  -19.37241 -16.46408 0.775 8.99112  ? 337  TRP A CD1 1 
ATOM   2704 C CD1 B TRP A 1 256 ? 35.21265  -16.57312 -17.94207 0.225 14.00949 ? 337  TRP A CD1 1 
ATOM   2705 C CD2 A TRP A 1 256 ? 32.90231  -17.16432 -16.37879 0.775 7.23171  ? 337  TRP A CD2 1 
ATOM   2706 C CD2 B TRP A 1 256 ? 33.35182  -16.86030 -16.73466 0.225 15.57823 ? 337  TRP A CD2 1 
ATOM   2707 N NE1 A TRP A 1 256 ? 31.48870  -18.85371 -16.02116 0.775 9.97902  ? 337  TRP A NE1 1 
ATOM   2708 N NE1 B TRP A 1 256 ? 34.46558  -15.42779 -18.04035 0.225 14.50784 ? 337  TRP A NE1 1 
ATOM   2709 C CE2 A TRP A 1 256 ? 31.59942  -17.49053 -15.96398 0.775 9.23682  ? 337  TRP A CE2 1 
ATOM   2710 C CE2 B TRP A 1 256 ? 33.31650  -15.57876 -17.31138 0.225 15.50085 ? 337  TRP A CE2 1 
ATOM   2711 C CE3 A TRP A 1 256 ? 33.28423  -15.82673 -16.38605 0.775 10.04799 ? 337  TRP A CE3 1 
ATOM   2712 C CE3 B TRP A 1 256 ? 32.28419  -17.26644 -15.92813 0.225 13.87307 ? 337  TRP A CE3 1 
ATOM   2713 C CZ2 A TRP A 1 256 ? 30.67268  -16.50206 -15.57091 0.775 10.20857 ? 337  TRP A CZ2 1 
ATOM   2714 C CZ2 B TRP A 1 256 ? 32.25826  -14.69761 -17.10904 0.225 14.78932 ? 337  TRP A CZ2 1 
ATOM   2715 C CZ3 A TRP A 1 256 ? 32.37998  -14.86160 -16.01353 0.775 12.90682 ? 337  TRP A CZ3 1 
ATOM   2716 C CZ3 B TRP A 1 256 ? 31.23364  -16.38860 -15.72630 0.225 14.06605 ? 337  TRP A CZ3 1 
ATOM   2717 C CH2 A TRP A 1 256 ? 31.08912  -15.19838 -15.61402 0.775 13.30217 ? 337  TRP A CH2 1 
ATOM   2718 C CH2 B TRP A 1 256 ? 31.22942  -15.11988 -16.31485 0.225 14.78900 ? 337  TRP A CH2 1 
ATOM   2719 N N   A ASP A 1 257 ? 34.37155  -21.12108 -19.47165 0.775 12.31487 ? 338  ASP A N   1 
ATOM   2720 N N   B ASP A 1 257 ? 34.20637  -21.28053 -19.11977 0.225 8.95961  ? 338  ASP A N   1 
ATOM   2721 C CA  A ASP A 1 257 ? 33.65543  -21.39095 -20.71287 0.775 9.92745  ? 338  ASP A CA  1 
ATOM   2722 C CA  B ASP A 1 257 ? 33.25543  -21.67627 -20.16075 0.225 9.75296  ? 338  ASP A CA  1 
ATOM   2723 C C   A ASP A 1 257 ? 32.18880  -21.04860 -20.48281 0.775 9.89028  ? 338  ASP A C   1 
ATOM   2724 C C   B ASP A 1 257 ? 31.87999  -21.13130 -19.79998 0.225 10.90442 ? 338  ASP A C   1 
ATOM   2725 O O   A ASP A 1 257 ? 31.30997  -21.89847 -20.32521 0.775 10.85758 ? 338  ASP A O   1 
ATOM   2726 O O   B ASP A 1 257 ? 30.98114  -21.84417 -19.34267 0.225 13.09739 ? 338  ASP A O   1 
ATOM   2727 C CB  A ASP A 1 257 ? 33.86060  -22.82401 -21.16752 0.775 11.96733 ? 338  ASP A CB  1 
ATOM   2728 C CB  B ASP A 1 257 ? 33.23579  -23.18400 -20.36692 0.225 10.07702 ? 338  ASP A CB  1 
ATOM   2729 C CG  A ASP A 1 257 ? 33.39638  -23.04824 -22.59507 0.775 14.95924 ? 338  ASP A CG  1 
ATOM   2730 C CG  B ASP A 1 257 ? 33.15054  -23.56548 -21.82965 0.225 14.09537 ? 338  ASP A CG  1 
ATOM   2731 O OD1 A ASP A 1 257 ? 33.03480  -22.06958 -23.27939 0.775 13.99897 ? 338  ASP A OD1 1 
ATOM   2732 O OD1 B ASP A 1 257 ? 33.64751  -22.79828 -22.68179 0.225 15.33027 ? 338  ASP A OD1 1 
ATOM   2733 O OD2 A ASP A 1 257 ? 33.41066  -24.21332 -23.03960 0.775 17.02691 ? 338  ASP A OD2 1 
ATOM   2734 O OD2 B ASP A 1 257 ? 32.56834  -24.62717 -22.12752 0.225 16.47991 ? 338  ASP A OD2 1 
ATOM   2735 N N   A ALA A 1 258 ? 31.93064  -19.75611 -20.48605 0.775 8.32091  ? 339  ALA A N   1 
ATOM   2736 N N   B ALA A 1 258 ? 31.72107  -19.83226 -20.03114 0.225 9.51809  ? 339  ALA A N   1 
ATOM   2737 C CA  A ALA A 1 258 ? 30.65626  -19.23130 -20.05565 0.775 7.44187  ? 339  ALA A CA  1 
ATOM   2738 C CA  B ALA A 1 258 ? 30.50709  -19.11753 -19.66941 0.225 10.78054 ? 339  ALA A CA  1 
ATOM   2739 C C   A ALA A 1 258 ? 29.59916  -19.42946 -21.12974 0.775 6.69319  ? 339  ALA A C   1 
ATOM   2740 C C   B ALA A 1 258 ? 29.49324  -19.18081 -20.80466 0.225 9.57389  ? 339  ALA A C   1 
ATOM   2741 O O   A ALA A 1 258 ? 29.87898  -19.37049 -22.33010 0.775 7.74680  ? 339  ALA A O   1 
ATOM   2742 O O   B ALA A 1 258 ? 29.80227  -18.82047 -21.94728 0.225 9.33982  ? 339  ALA A O   1 
ATOM   2743 C CB  A ALA A 1 258 ? 30.81730  -17.74016 -19.79277 0.775 9.14617  ? 339  ALA A CB  1 
ATOM   2744 C CB  B ALA A 1 258 ? 30.83420  -17.66051 -19.34434 0.225 12.85658 ? 339  ALA A CB  1 
ATOM   2745 N N   A THR A 1 259 ? 28.36310  -19.59851 -20.68428 0.775 6.56747  ? 340  THR A N   1 
ATOM   2746 N N   B THR A 1 259 ? 28.28721  -19.64343 -20.48151 0.225 8.07152  ? 340  THR A N   1 
ATOM   2747 C CA  A THR A 1 259 ? 27.20717  -19.59506 -21.56116 0.775 7.18557  ? 340  THR A CA  1 
ATOM   2748 C CA  B THR A 1 259 ? 27.16531  -19.64690 -21.40378 0.225 7.41312  ? 340  THR A CA  1 
ATOM   2749 C C   A THR A 1 259 ? 26.24175  -18.50237 -21.11356 0.775 6.86851  ? 340  THR A C   1 
ATOM   2750 C C   B THR A 1 259 ? 26.31104  -18.40319 -21.16540 0.225 7.22112  ? 340  THR A C   1 
ATOM   2751 O O   A THR A 1 259 ? 26.41341  -17.86714 -20.07143 0.775 7.44750  ? 340  THR A O   1 
ATOM   2752 O O   B THR A 1 259 ? 26.61604  -17.56153 -20.31210 0.225 6.20936  ? 340  THR A O   1 
ATOM   2753 C CB  A THR A 1 259 ? 26.51697  -20.96707 -21.59727 0.775 6.81080  ? 340  THR A CB  1 
ATOM   2754 C CB  B THR A 1 259 ? 26.34208  -20.92360 -21.23716 0.225 10.61660 ? 340  THR A CB  1 
ATOM   2755 O OG1 A THR A 1 259 ? 26.17871  -21.35326 -20.26472 0.775 7.07385  ? 340  THR A OG1 1 
ATOM   2756 O OG1 B THR A 1 259 ? 26.26382  -21.25854 -19.84878 0.225 11.73865 ? 340  THR A OG1 1 
ATOM   2757 C CG2 A THR A 1 259 ? 27.43727  -22.00462 -22.23185 0.775 7.79686  ? 340  THR A CG2 1 
ATOM   2758 C CG2 B THR A 1 259 ? 26.98264  -22.07874 -21.99252 0.225 10.81966 ? 340  THR A CG2 1 
ATOM   2759 N N   . PHE A 1 260 ? 25.23208  -18.26561 -21.93858 1.000 6.75954  ? 341  PHE A N   1 
ATOM   2760 C CA  . PHE A 1 260 ? 24.44227  -17.04576 -21.88642 1.000 7.07133  ? 341  PHE A CA  1 
ATOM   2761 C C   . PHE A 1 260 ? 22.95805  -17.35448 -21.96910 1.000 6.46709  ? 341  PHE A C   1 
ATOM   2762 O O   . PHE A 1 260 ? 22.53590  -18.34112 -22.57685 1.000 7.19933  ? 341  PHE A O   1 
ATOM   2763 C CB  . PHE A 1 260 ? 24.78994  -16.12459 -23.07282 1.000 7.29960  ? 341  PHE A CB  1 
ATOM   2764 C CG  . PHE A 1 260 ? 26.16811  -15.52070 -23.00389 1.000 7.45559  ? 341  PHE A CG  1 
ATOM   2765 C CD1 . PHE A 1 260 ? 27.29318  -16.28547 -23.26083 1.000 8.35383  ? 341  PHE A CD1 1 
ATOM   2766 C CD2 . PHE A 1 260 ? 26.33091  -14.17859 -22.70085 1.000 8.54832  ? 341  PHE A CD2 1 
ATOM   2767 C CE1 . PHE A 1 260 ? 28.55018  -15.72823 -23.19519 1.000 9.10665  ? 341  PHE A CE1 1 
ATOM   2768 C CE2 . PHE A 1 260 ? 27.58513  -13.60668 -22.65701 1.000 9.13198  ? 341  PHE A CE2 1 
ATOM   2769 C CZ  . PHE A 1 260 ? 28.70063  -14.38308 -22.89836 1.000 9.77286  ? 341  PHE A CZ  1 
ATOM   2770 N N   . ILE A 1 261 ? 22.16095  -16.46457 -21.39206 1.000 6.27198  ? 342  ILE A N   1 
ATOM   2771 C CA  . ILE A 1 261 ? 20.73513  -16.40776 -21.66556 1.000 6.38613  ? 342  ILE A CA  1 
ATOM   2772 C C   . ILE A 1 261 ? 20.40425  -14.99216 -22.11343 1.000 6.28233  ? 342  ILE A C   1 
ATOM   2773 O O   . ILE A 1 261 ? 21.07354  -14.03449 -21.71297 1.000 7.10589  ? 342  ILE A O   1 
ATOM   2774 C CB  . ILE A 1 261 ? 19.87362  -16.86846 -20.46996 1.000 6.74781  ? 342  ILE A CB  1 
ATOM   2775 C CG1 . ILE A 1 261 ? 20.03317  -15.94414 -19.24875 1.000 7.10425  ? 342  ILE A CG1 1 
ATOM   2776 C CG2 . ILE A 1 261 ? 20.19030  -18.32465 -20.13652 1.000 7.14204  ? 342  ILE A CG2 1 
ATOM   2777 C CD1 . ILE A 1 261 ? 19.16786  -16.35705 -18.07513 1.000 7.93414  ? 342  ILE A CD1 1 
ATOM   2778 N N   . VAL A 1 262 ? 19.38330  -14.86158 -22.95950 1.000 6.45939  ? 343  VAL A N   1 
ATOM   2779 C CA  A VAL A 1 262 ? 19.03982  -13.58373 -23.57697 0.854 6.40418  ? 343  VAL A CA  1 
ATOM   2780 C CA  B VAL A 1 262 ? 19.04029  -13.57990 -23.56347 0.146 6.40800  ? 343  VAL A CA  1 
ATOM   2781 C C   . VAL A 1 262 ? 17.54524  -13.32251 -23.41383 1.000 6.32510  ? 343  VAL A C   1 
ATOM   2782 O O   . VAL A 1 262 ? 16.71549  -14.11258 -23.86933 1.000 6.75676  ? 343  VAL A O   1 
ATOM   2783 C CB  A VAL A 1 262 ? 19.41618  -13.54716 -25.06555 0.854 6.95471  ? 343  VAL A CB  1 
ATOM   2784 C CB  B VAL A 1 262 ? 19.49372  -13.47928 -25.03269 0.146 6.81709  ? 343  VAL A CB  1 
ATOM   2785 C CG1 A VAL A 1 262 ? 19.09784  -12.18474 -25.64500 0.854 7.30290  ? 343  VAL A CG1 1 
ATOM   2786 C CG1 B VAL A 1 262 ? 21.01100  -13.49070 -25.11823 0.146 7.87208  ? 343  VAL A CG1 1 
ATOM   2787 C CG2 A VAL A 1 262 ? 20.86444  -13.90408 -25.27243 0.854 7.98848  ? 343  VAL A CG2 1 
ATOM   2788 C CG2 B VAL A 1 262 ? 18.92074  -14.60688 -25.86889 0.146 5.61575  ? 343  VAL A CG2 1 
ATOM   2789 N N   . ASP A 1 263 ? 17.20208  -12.20088 -22.78821 1.000 6.70209  ? 344  ASP A N   1 
ATOM   2790 C CA  . ASP A 1 263 ? 15.80862  -11.77837 -22.68832 1.000 6.50632  ? 344  ASP A CA  1 
ATOM   2791 C C   . ASP A 1 263 ? 15.33792  -11.34482 -24.07132 1.000 6.35463  ? 344  ASP A C   1 
ATOM   2792 O O   . ASP A 1 263 ? 16.00175  -10.54007 -24.73266 1.000 7.18501  ? 344  ASP A O   1 
ATOM   2793 C CB  . ASP A 1 263 ? 15.72452  -10.58976 -21.71293 1.000 6.81859  ? 344  ASP A CB  1 
ATOM   2794 C CG  . ASP A 1 263 ? 14.32525  -10.33303 -21.13841 1.000 6.67383  ? 344  ASP A CG  1 
ATOM   2795 O OD1 . ASP A 1 263 ? 13.33822  -10.91928 -21.63495 1.000 6.96406  ? 344  ASP A OD1 1 
ATOM   2796 O OD2 . ASP A 1 263 ? 14.24419  -9.53014  -20.16618 1.000 7.24303  ? 344  ASP A OD2 1 
ATOM   2797 N N   . GLN A 1 264 ? 14.20121  -11.89018 -24.51391 1.000 6.71556  ? 345  GLN A N   1 
ATOM   2798 C CA  . GLN A 1 264 ? 13.52463  -11.42933 -25.71705 1.000 7.03707  ? 345  GLN A CA  1 
ATOM   2799 C C   . GLN A 1 264 ? 12.06194  -11.09491 -25.44733 1.000 6.90473  ? 345  GLN A C   1 
ATOM   2800 O O   . GLN A 1 264 ? 11.29108  -10.91573 -26.39848 1.000 7.54854  ? 345  GLN A O   1 
ATOM   2801 C CB  . GLN A 1 264 ? 13.63899  -12.46707 -26.84678 1.000 7.48834  ? 345  GLN A CB  1 
ATOM   2802 C CG  . GLN A 1 264 ? 15.05149  -12.61540 -27.39852 1.000 7.72883  ? 345  GLN A CG  1 
ATOM   2803 C CD  . GLN A 1 264 ? 15.46035  -11.43760 -28.26293 1.000 7.53464  ? 345  GLN A CD  1 
ATOM   2804 O OE1 . GLN A 1 264 ? 15.10076  -11.36004 -29.43377 1.000 8.22484  ? 345  GLN A OE1 1 
ATOM   2805 N NE2 . GLN A 1 264 ? 16.20550  -10.50619 -27.69115 1.000 8.11817  ? 345  GLN A NE2 1 
ATOM   2806 N N   . GLY A 1 265 ? 11.67399  -10.97707 -24.17788 1.000 6.82241  ? 346  GLY A N   1 
ATOM   2807 C CA  . GLY A 1 265 ? 10.27888  -10.77651 -23.84111 1.000 7.43825  ? 346  GLY A CA  1 
ATOM   2808 C C   . GLY A 1 265 ? 9.64631   -9.56933  -24.48797 1.000 7.70934  ? 346  GLY A C   1 
ATOM   2809 O O   . GLY A 1 265 ? 8.45442   -9.59542  -24.78683 1.000 9.93097  ? 346  GLY A O   1 
ATOM   2810 N N   . ARG A 1 266 ? 10.41251  -8.49986  -24.70823 1.000 7.49324  ? 347  ARG A N   1 
ATOM   2811 C CA  . ARG A 1 266 ? 9.87404   -7.28099  -25.30591 1.000 8.01330  ? 347  ARG A CA  1 
ATOM   2812 C C   . ARG A 1 266 ? 10.64190  -6.86899  -26.55830 1.000 7.96276  ? 347  ARG A C   1 
ATOM   2813 O O   . ARG A 1 266 ? 10.75884  -5.68032  -26.86585 1.000 9.07086  ? 347  ARG A O   1 
ATOM   2814 C CB  . ARG A 1 266 ? 9.77703   -6.14417  -24.28492 1.000 9.36149  ? 347  ARG A CB  1 
ATOM   2815 C CG  . ARG A 1 266 ? 8.95085   -6.51136  -23.05961 1.000 9.12924  ? 347  ARG A CG  1 
ATOM   2816 C CD  . ARG A 1 266 ? 8.69408   -5.33901  -22.14151 1.000 9.44578  ? 347  ARG A CD  1 
ATOM   2817 N NE  . ARG A 1 266 ? 9.93263   -4.83362  -21.56911 1.000 9.51369  ? 347  ARG A NE  1 
ATOM   2818 C CZ  . ARG A 1 266 ? 10.03688  -3.67890  -20.92890 1.000 11.39204 ? 347  ARG A CZ  1 
ATOM   2819 N NH1 . ARG A 1 266 ? 8.97552   -2.92183  -20.69063 1.000 14.78353 ? 347  ARG A NH1 1 
ATOM   2820 N NH2 . ARG A 1 266 ? 11.23176  -3.27853  -20.50431 1.000 13.00717 ? 347  ARG A NH2 1 
ATOM   2821 N N   . SER A 1 267 ? 11.12744  -7.85326  -27.31457 1.000 8.11765  ? 348  SER A N   1 
ATOM   2822 C CA  . SER A 1 267 ? 11.96143  -7.60761  -28.48318 1.000 8.25258  ? 348  SER A CA  1 
ATOM   2823 C C   . SER A 1 267 ? 11.24235  -7.84054  -29.80699 1.000 8.30501  ? 348  SER A C   1 
ATOM   2824 O O   . SER A 1 267 ? 11.88598  -7.82189  -30.86188 1.000 8.99293  ? 348  SER A O   1 
ATOM   2825 C CB  . SER A 1 267 ? 13.23383  -8.44631  -28.40427 1.000 8.66515  ? 348  SER A CB  1 
ATOM   2826 O OG  . SER A 1 267 ? 14.04800  -8.01226  -27.32351 1.000 8.44422  ? 348  SER A OG  1 
ATOM   2827 N N   . GLY A 1 268 ? 9.92484   -8.04144  -29.78271 1.000 8.07172  ? 349  GLY A N   1 
ATOM   2828 C CA  . GLY A 1 268 ? 9.20340   -8.35740  -31.00327 1.000 8.49146  ? 349  GLY A CA  1 
ATOM   2829 C C   . GLY A 1 268 ? 9.19664   -7.24336  -32.02991 1.000 9.04332  ? 349  GLY A C   1 
ATOM   2830 O O   . GLY A 1 268 ? 9.05832   -7.50284  -33.22646 1.000 10.11316 ? 349  GLY A O   1 
ATOM   2831 N N   . VAL A 1 269 ? 9.33175   -5.99824  -31.59118 1.000 8.74864  ? 350  VAL A N   1 
ATOM   2832 C CA  . VAL A 1 269 ? 9.32157   -4.84933  -32.48364 1.000 8.77758  ? 350  VAL A CA  1 
ATOM   2833 C C   . VAL A 1 269 ? 10.64611  -4.11520  -32.32899 1.000 8.71808  ? 350  VAL A C   1 
ATOM   2834 O O   . VAL A 1 269 ? 11.00048  -3.66480  -31.22889 1.000 8.93664  ? 350  VAL A O   1 
ATOM   2835 C CB  . VAL A 1 269 ? 8.12514   -3.91802  -32.22750 1.000 9.25455  ? 350  VAL A CB  1 
ATOM   2836 C CG1 . VAL A 1 269 ? 8.09571   -2.81035  -33.24921 1.000 10.80124 ? 350  VAL A CG1 1 
ATOM   2837 C CG2 . VAL A 1 269 ? 6.81797   -4.70386  -32.23916 1.000 10.38818 ? 350  VAL A CG2 1 
ATOM   2838 N N   . GLN A 1 270 ? 11.38080  -4.02093  -33.42879 1.000 9.59120  ? 351  GLN A N   1 
ATOM   2839 C CA  . GLN A 1 270 ? 12.64428  -3.30703  -33.49290 1.000 8.96185  ? 351  GLN A CA  1 
ATOM   2840 C C   . GLN A 1 270 ? 12.40346  -1.90012  -34.03260 1.000 9.26353  ? 351  GLN A C   1 
ATOM   2841 O O   . GLN A 1 270 ? 11.30329  -1.56490  -34.48361 1.000 10.02009 ? 351  GLN A O   1 
ATOM   2842 C CB  . GLN A 1 270 ? 13.63221  -4.09717  -34.35788 1.000 9.86365  ? 351  GLN A CB  1 
ATOM   2843 C CG  . GLN A 1 270 ? 13.97424  -5.43802  -33.71648 1.000 9.28939  ? 351  GLN A CG  1 
ATOM   2844 C CD  . GLN A 1 270 ? 14.62724  -5.24950  -32.37253 1.000 8.32989  ? 351  GLN A CD  1 
ATOM   2845 O OE1 . GLN A 1 270 ? 15.62445  -4.54874  -32.27501 1.000 9.33488  ? 351  GLN A OE1 1 
ATOM   2846 N NE2 . GLN A 1 270 ? 14.07451  -5.84704  -31.32554 1.000 8.72938  ? 351  GLN A NE2 1 
ATOM   2847 N N   . ASN A 1 271 ? 13.43428  -1.05767  -33.94395 1.000 8.84865  ? 352  ASN A N   1 
ATOM   2848 C CA  . ASN A 1 271 ? 13.39746  0.27111   -34.55489 1.000 9.38377  ? 352  ASN A CA  1 
ATOM   2849 C C   . ASN A 1 271 ? 12.30950  1.15715   -33.94189 1.000 9.50888  ? 352  ASN A C   1 
ATOM   2850 O O   . ASN A 1 271 ? 11.58424  1.86606   -34.65601 1.000 10.81164 ? 352  ASN A O   1 
ATOM   2851 C CB  . ASN A 1 271 ? 13.26272  0.20201   -36.08222 1.000 10.41211 ? 352  ASN A CB  1 
ATOM   2852 C CG  . ASN A 1 271 ? 14.44179  -0.50379  -36.75593 1.000 10.22824 ? 352  ASN A CG  1 
ATOM   2853 O OD1 . ASN A 1 271 ? 15.36829  -0.96708  -36.09767 1.000 9.96642  ? 352  ASN A OD1 1 
ATOM   2854 N ND2 . ASN A 1 271 ? 14.41394  -0.56622  -38.08119 1.000 12.28027 ? 352  ASN A ND2 1 
ATOM   2855 N N   A ILE A 1 272 ? 12.20414  1.12074   -32.60840 0.801 9.87885  ? 353  ILE A N   1 
ATOM   2856 N N   B ILE A 1 272 ? 12.20648  1.13414   -32.61413 0.199 9.96701  ? 353  ILE A N   1 
ATOM   2857 C CA  A ILE A 1 272 ? 11.19814  1.87647   -31.87290 0.801 10.57347 ? 353  ILE A CA  1 
ATOM   2858 C CA  B ILE A 1 272 ? 11.22216  1.94691   -31.91021 0.199 10.73289 ? 353  ILE A CA  1 
ATOM   2859 C C   A ILE A 1 272 ? 11.80863  2.90646   -30.92744 0.801 9.66244  ? 353  ILE A C   1 
ATOM   2860 C C   B ILE A 1 272 ? 11.83994  3.01297   -31.01552 0.199 10.29943 ? 353  ILE A C   1 
ATOM   2861 O O   A ILE A 1 272 ? 11.08617  3.52081   -30.14015 0.801 12.29543 ? 353  ILE A O   1 
ATOM   2862 O O   B ILE A 1 272 ? 11.15058  3.99185   -30.68399 0.199 9.75993  ? 353  ILE A O   1 
ATOM   2863 C CB  A ILE A 1 272 ? 10.20499  0.96398   -31.12651 0.801 10.78913 ? 353  ILE A CB  1 
ATOM   2864 C CB  B ILE A 1 272 ? 10.21241  1.09351   -31.11311 0.199 10.72258 ? 353  ILE A CB  1 
ATOM   2865 C CG1 A ILE A 1 272 ? 10.94542  -0.01709  -30.20614 0.801 10.76617 ? 353  ILE A CG1 1 
ATOM   2866 C CG1 B ILE A 1 272 ? 10.89352  -0.14162  -30.52245 0.199 10.84102 ? 353  ILE A CG1 1 
ATOM   2867 C CG2 A ILE A 1 272 ? 9.32621   0.22542   -32.11143 0.801 12.75509 ? 353  ILE A CG2 1 
ATOM   2868 C CG2 B ILE A 1 272 ? 9.03915   0.70222   -31.99549 0.199 11.64386 ? 353  ILE A CG2 1 
ATOM   2869 C CD1 A ILE A 1 272 ? 10.03576  -0.85459  -29.32215 0.801 12.06729 ? 353  ILE A CD1 1 
ATOM   2870 C CD1 B ILE A 1 272 ? 9.95767   -1.02937  -29.72754 0.199 12.21654 ? 353  ILE A CD1 1 
ATOM   2871 N N   A ARG A 1 273 ? 13.11901  3.12942   -30.99467 0.801 10.86406 ? 354  ARG A N   1 
ATOM   2872 N N   B ARG A 1 273 ? 13.09640  2.86923   -30.60262 0.199 9.40422  ? 354  ARG A N   1 
ATOM   2873 C CA  A ARG A 1 273 ? 13.78791  4.02408   -30.06161 0.801 10.58468 ? 354  ARG A CA  1 
ATOM   2874 C CA  B ARG A 1 273 ? 13.73845  3.85359   -29.74189 0.199 11.17732 ? 354  ARG A CA  1 
ATOM   2875 C C   A ARG A 1 273 ? 14.48910  5.16598   -30.78416 0.801 10.67459 ? 354  ARG A C   1 
ATOM   2876 C C   B ARG A 1 273 ? 14.32697  4.99593   -30.55646 0.199 10.68931 ? 354  ARG A C   1 
ATOM   2877 O O   A ARG A 1 273 ? 15.01844  5.00428   -31.88504 0.801 11.49364 ? 354  ARG A O   1 
ATOM   2878 O O   B ARG A 1 273 ? 14.85445  4.79337   -31.65251 0.199 11.92473 ? 354  ARG A O   1 
ATOM   2879 C CB  A ARG A 1 273 ? 14.81871  3.27036   -29.20695 0.801 10.10961 ? 354  ARG A CB  1 
ATOM   2880 C CB  B ARG A 1 273 ? 14.83817  3.18629   -28.91473 0.199 10.61326 ? 354  ARG A CB  1 
ATOM   2881 C CG  A ARG A 1 273 ? 14.18857  2.40572   -28.11311 0.801 9.80876  ? 354  ARG A CG  1 
ATOM   2882 C CG  B ARG A 1 273 ? 14.45038  2.96306   -27.47171 0.199 12.67866 ? 354  ARG A CG  1 
ATOM   2883 C CD  A ARG A 1 273 ? 15.22625  1.55983   -27.38088 0.801 9.78677  ? 354  ARG A CD  1 
ATOM   2884 C CD  B ARG A 1 273 ? 14.58243  1.51450   -27.03994 0.199 12.71047 ? 354  ARG A CD  1 
ATOM   2885 N NE  A ARG A 1 273 ? 15.66620  0.42029   -28.18158 0.801 8.47496  ? 354  ARG A NE  1 
ATOM   2886 N NE  B ARG A 1 273 ? 15.47995  0.70726   -27.85391 0.199 10.16712 ? 354  ARG A NE  1 
ATOM   2887 C CZ  A ARG A 1 273 ? 16.43609  -0.56198  -27.73127 0.801 8.42235  ? 354  ARG A CZ  1 
ATOM   2888 C CZ  B ARG A 1 273 ? 16.48414  -0.00006  -27.35728 0.199 8.38128  ? 354  ARG A CZ  1 
ATOM   2889 N NH1 A ARG A 1 273 ? 16.94697  -0.54016  -26.51354 0.801 9.87266  ? 354  ARG A NH1 1 
ATOM   2890 N NH1 B ARG A 1 273 ? 16.79694  0.05736   -26.07503 0.199 6.71845  ? 354  ARG A NH1 1 
ATOM   2891 N NH2 A ARG A 1 273 ? 16.70295  -1.59029  -28.52121 0.801 8.83615  ? 354  ARG A NH2 1 
ATOM   2892 N NH2 B ARG A 1 273 ? 17.17857  -0.80036  -28.16124 0.199 12.47983 ? 354  ARG A NH2 1 
ATOM   2893 N N   A GLN A 1 274 ? 14.50958  6.33042   -30.13472 0.801 10.96040 ? 355  GLN A N   1 
ATOM   2894 N N   B GLN A 1 274 ? 14.22323  6.20753   -30.01423 0.199 10.72335 ? 355  GLN A N   1 
ATOM   2895 C CA  A GLN A 1 274 ? 15.29408  7.43908   -30.66427 0.801 11.52811 ? 355  GLN A CA  1 
ATOM   2896 C CA  B GLN A 1 274 ? 14.88914  7.35446   -30.61388 0.199 10.76827 ? 355  GLN A CA  1 
ATOM   2897 C C   A GLN A 1 274 ? 16.77011  7.25742   -30.35343 0.801 11.61269 ? 355  GLN A C   1 
ATOM   2898 C C   B GLN A 1 274 ? 16.36642  7.42420   -30.25204 0.199 11.54628 ? 355  GLN A C   1 
ATOM   2899 O O   A GLN A 1 274 ? 17.61512  7.35789   -31.24988 0.801 12.08977 ? 355  GLN A O   1 
ATOM   2900 O O   B GLN A 1 274 ? 17.10215  8.20985   -30.85907 0.199 14.75771 ? 355  GLN A O   1 
ATOM   2901 C CB  A GLN A 1 274 ? 14.81446  8.77492   -30.10685 0.801 12.20325 ? 355  GLN A CB  1 
ATOM   2902 C CB  B GLN A 1 274 ? 14.17048  8.64629   -30.21649 0.199 12.70456 ? 355  GLN A CB  1 
ATOM   2903 C CG  A GLN A 1 274 ? 15.67117  9.93966   -30.57520 0.801 14.33177 ? 355  GLN A CG  1 
ATOM   2904 C CG  B GLN A 1 274 ? 12.86996  8.85994   -30.97049 0.199 14.31737 ? 355  GLN A CG  1 
ATOM   2905 C CD  A GLN A 1 274 ? 15.56999  10.15113  -32.07211 0.801 17.43165 ? 355  GLN A CD  1 
ATOM   2906 C CD  B GLN A 1 274 ? 11.99923  9.92918   -30.35377 0.199 14.91487 ? 355  GLN A CD  1 
ATOM   2907 O OE1 A GLN A 1 274 ? 16.57033  10.09443  -32.79051 0.801 21.60120 ? 355  GLN A OE1 1 
ATOM   2908 O OE1 B GLN A 1 274 ? 11.20424  9.65773   -29.45536 0.199 17.89882 ? 355  GLN A OE1 1 
ATOM   2909 N NE2 A GLN A 1 274 ? 14.35386  10.38000  -32.55347 0.801 17.71440 ? 355  GLN A NE2 1 
ATOM   2910 N NE2 B GLN A 1 274 ? 12.14453  11.15644  -30.83365 0.199 15.26501 ? 355  GLN A NE2 1 
ATOM   2911 N N   A GLN A 1 275 ? 17.09194  7.00222   -29.08576 0.801 10.37744 ? 356  GLN A N   1 
ATOM   2912 N N   B GLN A 1 275 ? 16.81112  6.61002   -29.29806 0.199 13.75257 ? 356  GLN A N   1 
ATOM   2913 C CA  A GLN A 1 275 ? 18.45941  6.77537   -28.65407 0.801 9.73212  ? 356  GLN A CA  1 
ATOM   2914 C CA  B GLN A 1 275 ? 18.19777  6.56763   -28.86130 0.199 11.64117 ? 356  GLN A CA  1 
ATOM   2915 C C   A GLN A 1 275 ? 18.53722  5.41496   -27.98155 0.801 9.95919  ? 356  GLN A C   1 
ATOM   2916 C C   B GLN A 1 275 ? 18.39338  5.25095   -28.12186 0.199 10.44864 ? 356  GLN A C   1 
ATOM   2917 O O   A GLN A 1 275 ? 17.58051  4.96787   -27.34252 0.801 10.05887 ? 356  GLN A O   1 
ATOM   2918 O O   B GLN A 1 275 ? 17.51748  4.83816   -27.35789 0.199 10.43923 ? 356  GLN A O   1 
ATOM   2919 C CB  A GLN A 1 275 ? 18.89977  7.85117   -27.66725 0.801 10.89981 ? 356  GLN A CB  1 
ATOM   2920 C CB  B GLN A 1 275 ? 18.49515  7.74779   -27.92916 0.199 13.68944 ? 356  GLN A CB  1 
ATOM   2921 C CG  A GLN A 1 275 ? 18.82110  9.24186   -28.23628 0.801 10.93031 ? 356  GLN A CG  1 
ATOM   2922 C CG  B GLN A 1 275 ? 19.92572  8.25005   -27.96557 0.199 14.86954 ? 356  GLN A CG  1 
ATOM   2923 C CD  A GLN A 1 275 ? 19.85037  10.14298  -27.63053 0.801 12.56277 ? 356  GLN A CD  1 
ATOM   2924 C CD  B GLN A 1 275 ? 20.13760  9.44750   -27.05799 0.199 15.91657 ? 356  GLN A CD  1 
ATOM   2925 O OE1 A GLN A 1 275 ? 19.81254  10.43430  -26.43465 0.801 15.58165 ? 356  GLN A OE1 1 
ATOM   2926 O OE1 B GLN A 1 275 ? 19.62391  9.48927   -25.94036 0.199 16.74209 ? 356  GLN A OE1 1 
ATOM   2927 N NE2 A GLN A 1 275 ? 20.80032  10.57612  -28.44392 0.801 13.62796 ? 356  GLN A NE2 1 
ATOM   2928 N NE2 B GLN A 1 275 ? 20.90603  10.42447  -27.53140 0.199 10.66948 ? 356  GLN A NE2 1 
ATOM   2929 N N   A TRP A 1 276 ? 19.68932  4.75965   -28.12696 0.801 9.58478  ? 357  TRP A N   1 
ATOM   2930 N N   B TRP A 1 276 ? 19.53735  4.59365   -28.35913 0.199 9.92204  ? 357  TRP A N   1 
ATOM   2931 C CA  A TRP A 1 276 ? 19.82003  3.39408   -27.62878 0.801 8.90647  ? 357  TRP A CA  1 
ATOM   2932 C CA  B TRP A 1 276 ? 19.77630  3.26634   -27.78262 0.199 9.82352  ? 357  TRP A CA  1 
ATOM   2933 C C   A TRP A 1 276 ? 19.60925  3.30529   -26.12485 0.801 9.37635  ? 357  TRP A C   1 
ATOM   2934 C C   B TRP A 1 276 ? 19.63759  3.26236   -26.26405 0.199 9.41618  ? 357  TRP A C   1 
ATOM   2935 O O   A TRP A 1 276 ? 19.07912  2.30137   -25.63087 0.801 10.66549 ? 357  TRP A O   1 
ATOM   2936 O O   B TRP A 1 276 ? 19.17556  2.26974   -25.68635 0.199 10.50639 ? 357  TRP A O   1 
ATOM   2937 C CB  A TRP A 1 276 ? 21.18955  2.83085   -27.99990 0.801 9.29015  ? 357  TRP A CB  1 
ATOM   2938 C CB  B TRP A 1 276 ? 21.16487  2.74701   -28.17978 0.199 8.32543  ? 357  TRP A CB  1 
ATOM   2939 C CG  A TRP A 1 276 ? 21.21336  1.34202   -28.17638 0.801 8.29563  ? 357  TRP A CG  1 
ATOM   2940 C CG  B TRP A 1 276 ? 21.27129  1.23818   -28.39943 0.199 8.89832  ? 357  TRP A CG  1 
ATOM   2941 C CD1 A TRP A 1 276 ? 20.26861  0.43146   -27.76833 0.801 8.12194  ? 357  TRP A CD1 1 
ATOM   2942 C CD1 B TRP A 1 276 ? 20.36109  0.27787   -28.04435 0.199 9.15203  ? 357  TRP A CD1 1 
ATOM   2943 C CD2 A TRP A 1 276 ? 22.23460  0.59267   -28.82973 0.801 8.16925  ? 357  TRP A CD2 1 
ATOM   2944 C CD2 B TRP A 1 276 ? 22.37542  0.53932   -28.99189 0.199 7.79110  ? 357  TRP A CD2 1 
ATOM   2945 N NE1 A TRP A 1 276 ? 20.65175  -0.84157  -28.13709 0.801 8.61582  ? 357  TRP A NE1 1 
ATOM   2946 N NE1 B TRP A 1 276 ? 20.82631  -0.97153  -28.40223 0.199 6.74056  ? 357  TRP A NE1 1 
ATOM   2947 C CE2 A TRP A 1 276 ? 21.85403  -0.76459  -28.79231 0.801 7.80654  ? 357  TRP A CE2 1 
ATOM   2948 C CE2 B TRP A 1 276 ? 22.05977  -0.83637  -28.98427 0.199 8.37083  ? 357  TRP A CE2 1 
ATOM   2949 C CE3 A TRP A 1 276 ? 23.44273  0.94081   -29.44069 0.801 8.70252  ? 357  TRP A CE3 1 
ATOM   2950 C CE3 B TRP A 1 276 ? 23.59673  0.94759   -29.53504 0.199 8.94730  ? 357  TRP A CE3 1 
ATOM   2951 C CZ2 A TRP A 1 276 ? 22.64761  -1.77361  -29.34240 0.801 9.04885  ? 357  TRP A CZ2 1 
ATOM   2952 C CZ2 B TRP A 1 276 ? 22.92379  -1.80320  -29.50243 0.199 7.55205  ? 357  TRP A CZ2 1 
ATOM   2953 C CZ3 A TRP A 1 276 ? 24.22625  -0.05415  -29.98584 0.801 9.31510  ? 357  TRP A CZ3 1 
ATOM   2954 C CZ3 B TRP A 1 276 ? 24.45255  -0.00890  -30.04477 0.199 8.46525  ? 357  TRP A CZ3 1 
ATOM   2955 C CH2 A TRP A 1 276 ? 23.83208  -1.39741  -29.92848 0.801 8.94359  ? 357  TRP A CH2 1 
ATOM   2956 C CH2 B TRP A 1 276 ? 24.11405  -1.37002  -30.02331 0.199 8.33621  ? 357  TRP A CH2 1 
ATOM   2957 N N   A GLY A 1 277 ? 20.02101  4.32967   -25.38558 0.801 10.43760 ? 358  GLY A N   1 
ATOM   2958 N N   B GLY A 1 277 ? 20.02721  4.35592   -25.60323 0.199 10.56661 ? 358  GLY A N   1 
ATOM   2959 C CA  A GLY A 1 277 ? 19.89533  4.31638   -23.94778 0.801 11.10142 ? 358  GLY A CA  1 
ATOM   2960 C CA  B GLY A 1 277 ? 19.97247  4.41689   -24.15297 0.199 11.61421 ? 358  GLY A CA  1 
ATOM   2961 C C   A GLY A 1 277 ? 18.50209  4.55304   -23.41344 0.801 10.41351 ? 358  GLY A C   1 
ATOM   2962 C C   B GLY A 1 277 ? 18.56997  4.45596   -23.58143 0.199 10.65768 ? 358  GLY A C   1 
ATOM   2963 O O   A GLY A 1 277 ? 18.32314  4.51801   -22.19421 0.801 11.52700 ? 358  GLY A O   1 
ATOM   2964 O O   B GLY A 1 277 ? 18.38227  4.09983   -22.41349 0.199 10.53936 ? 358  GLY A O   1 
ATOM   2965 N N   A ASP A 1 278 ? 17.51420  4.79648   -24.27272 0.801 10.25799 ? 359  ASP A N   1 
ATOM   2966 N N   B ASP A 1 278 ? 17.58473  4.88477   -24.36996 0.199 10.53157 ? 359  ASP A N   1 
ATOM   2967 C CA  A ASP A 1 278 ? 16.14911  5.04893   -23.81419 0.801 10.80599 ? 359  ASP A CA  1 
ATOM   2968 C CA  B ASP A 1 278 ? 16.21165  4.93544   -23.88233 0.199 10.85855 ? 359  ASP A CA  1 
ATOM   2969 C C   A ASP A 1 278 ? 15.53284  3.72090   -23.39728 0.801 10.07230 ? 359  ASP A C   1 
ATOM   2970 C C   B ASP A 1 278 ? 15.71495  3.53277   -23.55891 0.199 9.65562  ? 359  ASP A C   1 
ATOM   2971 O O   A ASP A 1 278 ? 15.21454  2.89044   -24.25208 0.801 11.88635 ? 359  ASP A O   1 
ATOM   2972 O O   B ASP A 1 278 ? 16.04877  2.56165   -24.24376 0.199 8.53471  ? 359  ASP A O   1 
ATOM   2973 C CB  A ASP A 1 278 ? 15.30571  5.65979   -24.93024 0.801 11.59849 ? 359  ASP A CB  1 
ATOM   2974 C CB  B ASP A 1 278 ? 15.29692  5.59349   -24.91852 0.199 11.63637 ? 359  ASP A CB  1 
ATOM   2975 C CG  A ASP A 1 278 ? 15.82923  6.99594   -25.42123 0.801 12.39935 ? 359  ASP A CG  1 
ATOM   2976 C CG  B ASP A 1 278 ? 15.85158  6.90709   -25.44127 0.199 12.39506 ? 359  ASP A CG  1 
ATOM   2977 O OD1 A ASP A 1 278 ? 16.72846  7.58143   -24.78310 0.801 12.30033 ? 359  ASP A OD1 1 
ATOM   2978 O OD1 B ASP A 1 278 ? 16.51382  7.63060   -24.66713 0.199 12.56177 ? 359  ASP A OD1 1 
ATOM   2979 O OD2 A ASP A 1 278 ? 15.31104  7.46449   -26.45772 0.801 11.54517 ? 359  ASP A OD2 1 
ATOM   2980 O OD2 B ASP A 1 278 ? 15.61563  7.22132   -26.62624 0.199 13.80822 ? 359  ASP A OD2 1 
ATOM   2981 N N   A TRP A 1 279 ? 15.31861  3.52892   -22.09528 0.801 10.51745 ? 360  TRP A N   1 
ATOM   2982 N N   B TRP A 1 279 ? 14.90630  3.42613   -22.50703 0.199 7.12877  ? 360  TRP A N   1 
ATOM   2983 C CA  A TRP A 1 279 ? 14.98099  2.21525   -21.56908 0.801 11.16822 ? 360  TRP A CA  1 
ATOM   2984 C CA  B TRP A 1 279 ? 14.55857  2.10390   -22.00521 0.199 8.26473  ? 360  TRP A CA  1 
ATOM   2985 C C   A TRP A 1 279 ? 13.57595  2.09661   -20.99705 0.801 10.26219 ? 360  TRP A C   1 
ATOM   2986 C C   B TRP A 1 279 ? 13.21033  2.05636   -21.29868 0.199 10.78653 ? 360  TRP A C   1 
ATOM   2987 O O   A TRP A 1 279 ? 13.13266  0.97167   -20.73576 0.801 10.68826 ? 360  TRP A O   1 
ATOM   2988 O O   B TRP A 1 279 ? 12.61755  0.98235   -21.17081 0.199 10.42617 ? 360  TRP A O   1 
ATOM   2989 C CB  A TRP A 1 279 ? 15.98481  1.79786   -20.48112 0.801 11.92882 ? 360  TRP A CB  1 
ATOM   2990 C CB  B TRP A 1 279 ? 15.65258  1.60708   -21.05638 0.199 12.65751 ? 360  TRP A CB  1 
ATOM   2991 C CG  A TRP A 1 279 ? 16.04423  2.77014   -19.33624 0.801 11.61115 ? 360  TRP A CG  1 
ATOM   2992 C CG  B TRP A 1 279 ? 15.90309  2.52807   -19.89878 0.199 12.98535 ? 360  TRP A CG  1 
ATOM   2993 C CD1 A TRP A 1 279 ? 16.91875  3.80811   -19.18919 0.801 13.46315 ? 360  TRP A CD1 1 
ATOM   2994 C CD1 B TRP A 1 279 ? 16.83606  3.52131   -19.82915 0.199 14.98523 ? 360  TRP A CD1 1 
ATOM   2995 C CD2 A TRP A 1 279 ? 15.17005  2.81908   -18.19970 0.801 11.14687 ? 360  TRP A CD2 1 
ATOM   2996 C CD2 B TRP A 1 279 ? 15.22243  2.52851   -18.63657 0.199 13.20024 ? 360  TRP A CD2 1 
ATOM   2997 N NE1 A TRP A 1 279 ? 16.65596  4.48672   -18.02400 0.801 14.77053 ? 360  TRP A NE1 1 
ATOM   2998 N NE1 B TRP A 1 279 ? 16.77211  4.14694   -18.60817 0.199 15.83450 ? 360  TRP A NE1 1 
ATOM   2999 C CE2 A TRP A 1 279 ? 15.58761  3.90011   -17.39943 0.801 13.13395 ? 360  TRP A CE2 1 
ATOM   3000 C CE2 B TRP A 1 279 ? 15.79103  3.55530   -17.85671 0.199 15.07599 ? 360  TRP A CE2 1 
ATOM   3001 C CE3 A TRP A 1 279 ? 14.09019  2.04290   -17.77005 0.801 12.80743 ? 360  TRP A CE3 1 
ATOM   3002 C CE3 B TRP A 1 279 ? 14.18918  1.76001   -18.09037 0.199 14.39252 ? 360  TRP A CE3 1 
ATOM   3003 C CZ2 A TRP A 1 279 ? 14.95248  4.23365   -16.20673 0.801 15.01777 ? 360  TRP A CZ2 1 
ATOM   3004 C CZ2 B TRP A 1 279 ? 15.35827  3.83659   -16.56331 0.199 15.27917 ? 360  TRP A CZ2 1 
ATOM   3005 C CZ3 A TRP A 1 279 ? 13.45735  2.38116   -16.58265 0.801 13.39821 ? 360  TRP A CZ3 1 
ATOM   3006 C CZ3 B TRP A 1 279 ? 13.75998  2.04225   -16.80708 0.199 16.30803 ? 360  TRP A CZ3 1 
ATOM   3007 C CH2 A TRP A 1 279 ? 13.89284  3.46354   -15.81615 0.801 15.45347 ? 360  TRP A CH2 1 
ATOM   3008 C CH2 B TRP A 1 279 ? 14.34410  3.07100   -16.05755 0.199 16.43144 ? 360  TRP A CH2 1 
ATOM   3009 N N   A CYS A 1 280 ? 12.86663  3.20118   -20.77538 0.801 11.88396 ? 361  CYS A N   1 
ATOM   3010 N N   B CYS A 1 280 ? 12.71473  3.19143   -20.82175 0.199 12.05078 ? 361  CYS A N   1 
ATOM   3011 C CA  A CYS A 1 280 ? 11.65978  3.19011   -19.95296 0.801 11.11686 ? 361  CYS A CA  1 
ATOM   3012 C CA  B CYS A 1 280 ? 11.56185  3.18993   -19.92816 0.199 11.28155 ? 361  CYS A CA  1 
ATOM   3013 C C   A CYS A 1 280 ? 10.38914  3.12290   -20.79527 0.801 10.90337 ? 361  CYS A C   1 
ATOM   3014 C C   B CYS A 1 280 ? 10.28164  3.28028   -20.75646 0.199 11.42030 ? 361  CYS A C   1 
ATOM   3015 O O   A CYS A 1 280 ? 10.09863  4.04682   -21.56194 0.801 11.77395 ? 361  CYS A O   1 
ATOM   3016 O O   B CYS A 1 280 ? 10.01641  4.30318   -21.39462 0.199 12.83111 ? 361  CYS A O   1 
ATOM   3017 C CB  A CYS A 1 280 ? 11.60782  4.40401   -19.03021 0.801 12.57387 ? 361  CYS A CB  1 
ATOM   3018 C CB  B CYS A 1 280 ? 11.67650  4.31647   -18.90252 0.199 12.33233 ? 361  CYS A CB  1 
ATOM   3019 S SG  A CYS A 1 280 ? 10.21632  4.28981   -17.90071 0.801 11.74505 ? 361  CYS A SG  1 
ATOM   3020 S SG  B CYS A 1 280 ? 10.47344  4.22885   -17.54967 0.199 11.59866 ? 361  CYS A SG  1 
ATOM   3021 N N   A ASN A 1 281 ? 9.61427   2.05223   -20.60467 0.801 10.51248 ? 362  ASN A N   1 
ATOM   3022 N N   B ASN A 1 281 ? 9.50340   2.19401   -20.76200 0.199 10.97680 ? 362  ASN A N   1 
ATOM   3023 C CA  A ASN A 1 281 ? 8.26866   1.91428   -21.17783 0.801 10.44720 ? 362  ASN A CA  1 
ATOM   3024 C CA  B ASN A 1 281 ? 8.16726   2.16233   -21.36466 0.199 9.62025  ? 362  ASN A CA  1 
ATOM   3025 C C   A ASN A 1 281 ? 8.22319   2.30701   -22.65802 0.801 10.60769 ? 362  ASN A C   1 
ATOM   3026 C C   B ASN A 1 281 ? 8.20089   2.48032   -22.85908 0.199 10.31638 ? 362  ASN A C   1 
ATOM   3027 O O   A ASN A 1 281 ? 7.36582   3.08111   -23.08379 0.801 11.10770 ? 362  ASN A O   1 
ATOM   3028 O O   B ASN A 1 281 ? 7.38951   3.25647   -23.36903 0.199 11.02594 ? 362  ASN A O   1 
ATOM   3029 C CB  A ASN A 1 281 ? 7.22107   2.71432   -20.39015 0.801 11.25310 ? 362  ASN A CB  1 
ATOM   3030 C CB  B ASN A 1 281 ? 7.20150   3.08912   -20.62589 0.199 11.89189 ? 362  ASN A CB  1 
ATOM   3031 C CG  A ASN A 1 281 ? 7.17164   2.36765   -18.91010 0.801 12.16357 ? 362  ASN A CG  1 
ATOM   3032 C CG  B ASN A 1 281 ? 6.93259   2.63875   -19.20975 0.199 10.56691 ? 362  ASN A CG  1 
ATOM   3033 O OD1 A ASN A 1 281 ? 7.33116   1.21434   -18.51734 0.801 12.27986 ? 362  ASN A OD1 1 
ATOM   3034 O OD1 B ASN A 1 281 ? 6.96043   1.44519   -18.90756 0.199 9.67282  ? 362  ASN A OD1 1 
ATOM   3035 N ND2 A ASN A 1 281 ? 6.90455   3.38072   -18.08063 0.801 12.58212 ? 362  ASN A ND2 1 
ATOM   3036 N ND2 B ASN A 1 281 ? 6.68622   3.59634   -18.32488 0.199 9.39885  ? 362  ASN A ND2 1 
ATOM   3037 N N   A ILE A 1 282 ? 9.14698   1.76931   -23.45860 0.801 10.37034 ? 363  ILE A N   1 
ATOM   3038 N N   B ILE A 1 282 ? 9.14365   1.86176   -23.56742 0.199 10.28939 ? 363  ILE A N   1 
ATOM   3039 C CA  A ILE A 1 282 ? 9.25799   2.23632   -24.83833 0.801 10.90780 ? 363  ILE A CA  1 
ATOM   3040 C CA  B ILE A 1 282 ? 9.32907   2.14211   -24.98727 0.199 10.97958 ? 363  ILE A CA  1 
ATOM   3041 C C   A ILE A 1 282 ? 7.98926   1.90385   -25.61297 0.801 10.64472 ? 363  ILE A C   1 
ATOM   3042 C C   B ILE A 1 282 ? 8.04396   1.85733   -25.75268 0.199 10.63016 ? 363  ILE A C   1 
ATOM   3043 O O   A ILE A 1 282 ? 7.50854   0.76158   -25.61082 0.801 10.02214 ? 363  ILE A O   1 
ATOM   3044 O O   B ILE A 1 282 ? 7.59269   0.70913   -25.84942 0.199 9.67753  ? 363  ILE A O   1 
ATOM   3045 C CB  A ILE A 1 282 ? 10.51593  1.67042   -25.50870 0.801 10.64024 ? 363  ILE A CB  1 
ATOM   3046 C CB  B ILE A 1 282 ? 10.53988  1.39511   -25.57164 0.199 11.34028 ? 363  ILE A CB  1 
ATOM   3047 C CG1 A ILE A 1 282 ? 11.78553  2.18084   -24.80910 0.801 10.86077 ? 363  ILE A CG1 1 
ATOM   3048 C CG1 B ILE A 1 282 ? 11.83696  1.91822   -24.94555 0.199 11.90100 ? 363  ILE A CG1 1 
ATOM   3049 C CG2 A ILE A 1 282 ? 10.52801  2.03793   -26.98836 0.801 10.97035 ? 363  ILE A CG2 1 
ATOM   3050 C CG2 B ILE A 1 282 ? 10.58273  1.55491   -27.08088 0.199 11.59484 ? 363  ILE A CG2 1 
ATOM   3051 C CD1 A ILE A 1 282 ? 11.97178  3.67331   -24.85334 0.801 11.90466 ? 363  ILE A CD1 1 
ATOM   3052 C CD1 B ILE A 1 282 ? 11.86854  3.41459   -24.69978 0.199 11.68996 ? 363  ILE A CD1 1 
ATOM   3053 N N   . LYS A 1 283 ? 7.44559   2.91862   -26.28314 1.000 11.00263 ? 364  LYS A N   1 
ATOM   3054 C CA  . LYS A 1 283 ? 6.14679   2.82360   -26.93219 1.000 12.21354 ? 364  LYS A CA  1 
ATOM   3055 C C   . LYS A 1 283 ? 6.21646   1.91977   -28.15469 1.000 11.19240 ? 364  LYS A C   1 
ATOM   3056 O O   . LYS A 1 283 ? 7.15735   2.00004   -28.94699 1.000 12.04455 ? 364  LYS A O   1 
ATOM   3057 C CB  . LYS A 1 283 ? 5.72609   4.23107   -27.35528 1.000 14.68826 ? 364  LYS A CB  1 
ATOM   3058 C CG  . LYS A 1 283 ? 4.29419   4.37120   -27.82566 1.000 17.41608 ? 364  LYS A CG  1 
ATOM   3059 C CD  . LYS A 1 283 ? 3.89599   5.84090   -27.84679 1.000 26.29116 ? 364  LYS A CD  1 
ATOM   3060 C CE  . LYS A 1 283 ? 3.54222   6.30897   -29.24824 1.000 31.08339 ? 364  LYS A CE  1 
ATOM   3061 N NZ  . LYS A 1 283 ? 3.22426   7.76562   -29.27576 1.000 29.64930 ? 364  LYS A NZ  1 
ATOM   3062 N N   . GLY A 1 284 ? 5.20648   1.06706   -28.30975 1.000 11.44964 ? 365  GLY A N   1 
ATOM   3063 C CA  . GLY A 1 284 ? 5.11871   0.17738   -29.44727 1.000 11.19222 ? 365  GLY A CA  1 
ATOM   3064 C C   . GLY A 1 284 ? 5.85077   -1.13397  -29.29624 1.000 10.22351 ? 365  GLY A C   1 
ATOM   3065 O O   . GLY A 1 284 ? 5.92071   -1.90644  -30.25669 1.000 11.25252 ? 365  GLY A O   1 
ATOM   3066 N N   . ALA A 1 285 ? 6.40247   -1.41827  -28.12335 1.000 9.75648  ? 366  ALA A N   1 
ATOM   3067 C CA  . ALA A 1 285 ? 7.05992   -2.69872  -27.92476 1.000 9.50086  ? 366  ALA A CA  1 
ATOM   3068 C C   . ALA A 1 285 ? 6.07033   -3.85400  -28.07122 1.000 9.64057  ? 366  ALA A C   1 
ATOM   3069 O O   . ALA A 1 285 ? 4.88365   -3.74101  -27.73528 1.000 10.02618 ? 366  ALA A O   1 
ATOM   3070 C CB  . ALA A 1 285 ? 7.71357   -2.74718  -26.54220 1.000 10.26248 ? 366  ALA A CB  1 
ATOM   3071 N N   . GLY A 1 286 ? 6.57947   -4.97462  -28.57072 1.000 9.00850  ? 367  GLY A N   1 
ATOM   3072 C CA  . GLY A 1 286 ? 5.78903   -6.18302  -28.70415 1.000 9.21712  ? 367  GLY A CA  1 
ATOM   3073 C C   . GLY A 1 286 ? 6.49214   -7.36401  -28.06917 1.000 8.56465  ? 367  GLY A C   1 
ATOM   3074 O O   . GLY A 1 286 ? 7.72158   -7.41248  -27.99615 1.000 8.58729  ? 367  GLY A O   1 
ATOM   3075 N N   . PHE A 1 287 ? 5.69753   -8.33563  -27.61434 1.000 8.78923  ? 368  PHE A N   1 
ATOM   3076 C CA  . PHE A 1 287 ? 6.28414   -9.57252  -27.11908 1.000 8.63056  ? 368  PHE A CA  1 
ATOM   3077 C C   . PHE A 1 287 ? 7.13631   -10.19763 -28.22375 1.000 8.34779  ? 368  PHE A C   1 
ATOM   3078 O O   . PHE A 1 287 ? 6.77102   -10.15794 -29.40324 1.000 9.68241  ? 368  PHE A O   1 
ATOM   3079 C CB  . PHE A 1 287 ? 5.18259   -10.54310 -26.69022 1.000 9.86923  ? 368  PHE A CB  1 
ATOM   3080 C CG  . PHE A 1 287 ? 4.54290   -10.22315 -25.35428 1.000 8.65857  ? 368  PHE A CG  1 
ATOM   3081 C CD1 . PHE A 1 287 ? 5.30049   -10.11385 -24.20512 1.000 9.44722  ? 368  PHE A CD1 1 
ATOM   3082 C CD2 . PHE A 1 287 ? 3.16685   -10.05597 -25.25075 1.000 9.83324  ? 368  PHE A CD2 1 
ATOM   3083 C CE1 . PHE A 1 287 ? 4.70938   -9.85925  -22.98479 1.000 10.05223 ? 368  PHE A CE1 1 
ATOM   3084 C CE2 . PHE A 1 287 ? 2.57186   -9.79097  -24.01782 1.000 11.04434 ? 368  PHE A CE2 1 
ATOM   3085 C CZ  . PHE A 1 287 ? 3.34548   -9.68952  -22.89264 1.000 10.51456 ? 368  PHE A CZ  1 
ATOM   3086 N N   . GLY A 1 288 ? 8.28899   -10.75872 -27.84409 1.000 8.52009  ? 369  GLY A N   1 
ATOM   3087 C CA  . GLY A 1 288 ? 9.22476   -11.32097 -28.78659 1.000 9.19562  ? 369  GLY A CA  1 
ATOM   3088 C C   . GLY A 1 288 ? 9.26858   -12.83679 -28.78279 1.000 8.52487  ? 369  GLY A C   1 
ATOM   3089 O O   . GLY A 1 288 ? 8.32624   -13.52352 -28.36699 1.000 9.49691  ? 369  GLY A O   1 
ATOM   3090 N N   . THR A 1 289 ? 10.38172  -13.36962 -29.28723 1.000 8.75266  ? 370  THR A N   1 
ATOM   3091 C CA  . THR A 1 289 ? 10.57330  -14.81375 -29.41816 1.000 8.82466  ? 370  THR A CA  1 
ATOM   3092 C C   . THR A 1 289 ? 10.29470  -15.50018 -28.09331 1.000 8.20535  ? 370  THR A C   1 
ATOM   3093 O O   . THR A 1 289 ? 10.79572  -15.07523 -27.05183 1.000 8.19612  ? 370  THR A O   1 
ATOM   3094 C CB  . THR A 1 289 ? 12.01913  -15.07708 -29.84132 1.000 8.89812  ? 370  THR A CB  1 
ATOM   3095 O OG1 . THR A 1 289 ? 12.28482  -14.41011 -31.07804 1.000 10.53084 ? 370  THR A OG1 1 
ATOM   3096 C CG2 . THR A 1 289 ? 12.31160  -16.56081 -29.98442 1.000 10.37170 ? 370  THR A CG2 1 
ATOM   3097 N N   . ARG A 1 290 ? 9.48947   -16.55919 -28.13214 1.000 9.19430  ? 371  ARG A N   1 
ATOM   3098 C CA  A ARG A 1 290 ? 9.13323   -17.28114 -26.91975 0.521 9.06268  ? 371  ARG A CA  1 
ATOM   3099 C CA  B ARG A 1 290 ? 9.14339   -17.24522 -26.90431 0.479 9.09971  ? 371  ARG A CA  1 
ATOM   3100 C C   . ARG A 1 290 ? 10.35722  -17.99261 -26.34807 1.000 8.39135  ? 371  ARG A C   1 
ATOM   3101 O O   . ARG A 1 290 ? 11.25599  -18.39908 -27.09710 1.000 8.75972  ? 371  ARG A O   1 
ATOM   3102 C CB  A ARG A 1 290 ? 8.04673   -18.32048 -27.20753 0.521 11.37715 ? 371  ARG A CB  1 
ATOM   3103 C CB  B ARG A 1 290 ? 7.98123   -18.20917 -27.13301 0.479 11.45460 ? 371  ARG A CB  1 
ATOM   3104 C CG  A ARG A 1 290 ? 6.93362   -17.85289 -28.12392 0.521 9.90548  ? 371  ARG A CG  1 
ATOM   3105 C CG  B ARG A 1 290 ? 6.63096   -17.66920 -26.66736 0.479 15.55476 ? 371  ARG A CG  1 
ATOM   3106 C CD  A ARG A 1 290 ? 6.10701   -16.77849 -27.46737 0.521 11.96987 ? 371  ARG A CD  1 
ATOM   3107 C CD  B ARG A 1 290 ? 6.33763   -16.31573 -27.28258 0.479 11.92659 ? 371  ARG A CD  1 
ATOM   3108 N NE  A ARG A 1 290 ? 6.27568   -15.48012 -28.11114 0.521 13.77726 ? 371  ARG A NE  1 
ATOM   3109 N NE  B ARG A 1 290 ? 5.12245   -16.34429 -28.08611 0.479 11.41995 ? 371  ARG A NE  1 
ATOM   3110 C CZ  A ARG A 1 290 ? 5.70077   -15.10460 -29.24678 0.521 13.34707 ? 371  ARG A CZ  1 
ATOM   3111 C CZ  B ARG A 1 290 ? 4.86966   -15.50719 -29.08206 0.479 10.77967 ? 371  ARG A CZ  1 
ATOM   3112 N NH1 A ARG A 1 290 ? 4.89608   -15.91218 -29.92001 0.521 16.20655 ? 371  ARG A NH1 1 
ATOM   3113 N NH1 B ARG A 1 290 ? 5.71388   -14.53637 -29.40158 0.479 10.29725 ? 371  ARG A NH1 1 
ATOM   3114 N NH2 A ARG A 1 290 ? 5.92830   -13.88016 -29.70990 0.521 13.22519 ? 371  ARG A NH2 1 
ATOM   3115 N NH2 B ARG A 1 290 ? 3.75194   -15.65665 -29.78579 0.479 13.13501 ? 371  ARG A NH2 1 
ATOM   3116 N N   . PRO A 1 291 ? 10.41208  -18.17143 -25.02845 1.000 7.81687  ? 372  PRO A N   1 
ATOM   3117 C CA  . PRO A 1 291 ? 11.54282  -18.88588 -24.43249 1.000 8.11212  ? 372  PRO A CA  1 
ATOM   3118 C C   . PRO A 1 291 ? 11.75922  -20.25158 -25.07460 1.000 8.00885  ? 372  PRO A C   1 
ATOM   3119 O O   . PRO A 1 291 ? 10.80856  -20.99087 -25.36160 1.000 8.86600  ? 372  PRO A O   1 
ATOM   3120 C CB  . PRO A 1 291 ? 11.14418  -19.01075 -22.96242 1.000 8.23892  ? 372  PRO A CB  1 
ATOM   3121 C CG  . PRO A 1 291 ? 10.26039  -17.79635 -22.74286 1.000 8.81226  ? 372  PRO A CG  1 
ATOM   3122 C CD  . PRO A 1 291 ? 9.47938   -17.66424 -24.00608 1.000 8.67445  ? 372  PRO A CD  1 
ATOM   3123 N N   . THR A 1 292 ? 13.03324  -20.57518 -25.29809 1.000 7.69978  ? 373  THR A N   1 
ATOM   3124 C CA  . THR A 1 292 ? 13.42179  -21.82093 -25.95300 1.000 8.53572  ? 373  THR A CA  1 
ATOM   3125 C C   . THR A 1 292 ? 14.91872  -22.04258 -25.79804 1.000 7.69654  ? 373  THR A C   1 
ATOM   3126 O O   . THR A 1 292 ? 15.69808  -21.08943 -25.79748 1.000 7.95453  ? 373  THR A O   1 
ATOM   3127 C CB  . THR A 1 292 ? 13.07294  -21.79604 -27.45240 1.000 9.23526  ? 373  THR A CB  1 
ATOM   3128 O OG1 . THR A 1 292 ? 13.50337  -23.02126 -28.04679 1.000 9.96203  ? 373  THR A OG1 1 
ATOM   3129 C CG2 . THR A 1 292 ? 13.74818  -20.62403 -28.19006 1.000 9.80398  ? 373  THR A CG2 1 
ATOM   3130 N N   A THR A 1 293 ? 15.32316  -23.30818 -25.70875 0.537 8.47918  ? 374  THR A N   1 
ATOM   3131 N N   B THR A 1 293 ? 15.30312  -23.31937 -25.68038 0.463 8.51085  ? 374  THR A N   1 
ATOM   3132 C CA  A THR A 1 293 ? 16.74234  -23.63163 -25.78810 0.537 8.44693  ? 374  THR A CA  1 
ATOM   3133 C CA  B THR A 1 293 ? 16.70620  -23.70822 -25.72222 0.463 8.38969  ? 374  THR A CA  1 
ATOM   3134 C C   A THR A 1 293 ? 17.22441  -23.80432 -27.22482 0.537 9.28101  ? 374  THR A C   1 
ATOM   3135 C C   B THR A 1 293 ? 17.22470  -23.82674 -27.15054 0.463 9.19412  ? 374  THR A C   1 
ATOM   3136 O O   A THR A 1 293 ? 18.37995  -24.18856 -27.43412 0.537 9.48013  ? 374  THR A O   1 
ATOM   3137 O O   B THR A 1 293 ? 18.44455  -23.88484 -27.35869 0.463 9.20867  ? 374  THR A O   1 
ATOM   3138 C CB  A THR A 1 293 ? 17.08089  -24.87424 -24.95569 0.537 8.97761  ? 374  THR A CB  1 
ATOM   3139 C CB  B THR A 1 293 ? 16.91982  -25.03876 -24.98735 0.463 10.24374 ? 374  THR A CB  1 
ATOM   3140 O OG1 A THR A 1 293 ? 16.52806  -26.03529 -25.58938 0.537 8.19913  ? 374  THR A OG1 1 
ATOM   3141 O OG1 B THR A 1 293 ? 15.91093  -25.98124 -25.37490 0.463 11.01555 ? 374  THR A OG1 1 
ATOM   3142 C CG2 A THR A 1 293 ? 16.52761  -24.74538 -23.53237 0.537 9.63266  ? 374  THR A CG2 1 
ATOM   3143 C CG2 B THR A 1 293 ? 16.84955  -24.83519 -23.48200 0.463 8.94690  ? 374  THR A CG2 1 
ATOM   3144 N N   A ASN A 1 294 ? 16.36632  -23.53066 -28.21347 0.537 7.93005  ? 375  ASN A N   1 
ATOM   3145 N N   B ASN A 1 294 ? 16.33240  -23.85566 -28.14211 0.463 9.57510  ? 375  ASN A N   1 
ATOM   3146 C CA  A ASN A 1 294 ? 16.74940  -23.53550 -29.62499 0.537 10.36253 ? 375  ASN A CA  1 
ATOM   3147 C CA  B ASN A 1 294 ? 16.74413  -23.90570 -29.54444 0.463 9.39132  ? 375  ASN A CA  1 
ATOM   3148 C C   A ASN A 1 294 ? 17.20419  -22.11710 -29.95143 0.537 9.29037  ? 375  ASN A C   1 
ATOM   3149 C C   B ASN A 1 294 ? 17.12962  -22.49315 -29.96671 0.463 9.37782  ? 375  ASN A C   1 
ATOM   3150 O O   A ASN A 1 294 ? 16.44399  -21.27934 -30.44065 0.537 11.13499 ? 375  ASN A O   1 
ATOM   3151 O O   B ASN A 1 294 ? 16.37744  -21.76870 -30.62317 0.463 11.12826 ? 375  ASN A O   1 
ATOM   3152 C CB  A ASN A 1 294 ? 15.56733  -23.96699 -30.48434 0.537 11.16191 ? 375  ASN A CB  1 
ATOM   3153 C CB  B ASN A 1 294 ? 15.63977  -24.48789 -30.41165 0.463 11.01001 ? 375  ASN A CB  1 
ATOM   3154 C CG  A ASN A 1 294 ? 15.89057  -23.97419 -31.96276 0.537 13.60394 ? 375  ASN A CG  1 
ATOM   3155 C CG  B ASN A 1 294 ? 15.18320  -25.83799 -29.92492 0.463 14.93687 ? 375  ASN A CG  1 
ATOM   3156 O OD1 A ASN A 1 294 ? 17.04348  -24.14262 -32.35966 0.537 15.63894 ? 375  ASN A OD1 1 
ATOM   3157 O OD1 B ASN A 1 294 ? 15.96511  -26.78237 -29.87683 0.463 18.04965 ? 375  ASN A OD1 1 
ATOM   3158 N ND2 A ASN A 1 294 ? 14.86789  -23.79377 -32.79012 0.537 18.06347 ? 375  ASN A ND2 1 
ATOM   3159 N ND2 B ASN A 1 294 ? 13.90739  -25.94568 -29.57917 0.463 18.03788 ? 375  ASN A ND2 1 
ATOM   3160 N N   A THR A 1 295 ? 18.46954  -21.84288 -29.65280 0.537 9.60177  ? 376  THR A N   1 
ATOM   3161 N N   B THR A 1 295 ? 18.33610  -22.10217 -29.56290 0.463 8.57729  ? 376  THR A N   1 
ATOM   3162 C CA  A THR A 1 295 ? 18.94215  -20.47029 -29.55711 0.537 9.42542  ? 376  THR A CA  1 
ATOM   3163 C CA  B THR A 1 295 ? 18.83393  -20.74660 -29.73535 0.463 9.36508  ? 376  THR A CA  1 
ATOM   3164 C C   A THR A 1 295 ? 19.72159  -20.00216 -30.77129 0.537 9.89586  ? 376  THR A C   1 
ATOM   3165 C C   B THR A 1 295 ? 19.66220  -20.57122 -30.99527 0.463 9.80270  ? 376  THR A C   1 
ATOM   3166 O O   A THR A 1 295 ? 19.94367  -18.79707 -30.90986 0.537 10.60853 ? 376  THR A O   1 
ATOM   3167 O O   B THR A 1 295 ? 19.85860  -19.43170 -31.43620 0.463 10.71977 ? 376  THR A O   1 
ATOM   3168 C CB  A THR A 1 295 ? 19.84855  -20.32538 -28.34249 0.537 8.86644  ? 376  THR A CB  1 
ATOM   3169 C CB  B THR A 1 295 ? 19.76138  -20.39364 -28.57617 0.463 9.18204  ? 376  THR A CB  1 
ATOM   3170 O OG1 A THR A 1 295 ? 21.06171  -21.03891 -28.60110 0.537 8.07757  ? 376  THR A OG1 1 
ATOM   3171 O OG1 B THR A 1 295 ? 20.86835  -21.30129 -28.60469 0.463 7.95940  ? 376  THR A OG1 1 
ATOM   3172 C CG2 A THR A 1 295 ? 19.15029  -20.88883 -27.08810 0.537 9.60425  ? 376  THR A CG2 1 
ATOM   3173 C CG2 B THR A 1 295 ? 19.03644  -20.47162 -27.23225 0.463 8.40810  ? 376  THR A CG2 1 
ATOM   3174 N N   A GLY A 1 296 ? 20.16282  -20.91008 -31.63406 0.537 9.92958  ? 377  GLY A N   1 
ATOM   3175 N N   B GLY A 1 296 ? 20.18213  -21.65361 -31.56454 0.463 9.08575  ? 377  GLY A N   1 
ATOM   3176 C CA  A GLY A 1 296 ? 20.96974  -20.53014 -32.77533 0.537 11.28743 ? 377  GLY A CA  1 
ATOM   3177 C CA  B GLY A 1 296 ? 21.04072  -21.52282 -32.72001 0.463 10.99123 ? 377  GLY A CA  1 
ATOM   3178 C C   A GLY A 1 296 ? 22.43286  -20.26531 -32.48830 0.537 9.98530  ? 377  GLY A C   1 
ATOM   3179 C C   B GLY A 1 296 ? 22.44690  -21.03279 -32.45066 0.463 9.79876  ? 377  GLY A C   1 
ATOM   3180 O O   A GLY A 1 296 ? 23.13893  -19.78634 -33.38534 0.537 11.57404 ? 377  GLY A O   1 
ATOM   3181 O O   B GLY A 1 296 ? 23.19128  -20.79360 -33.40845 0.463 10.75825 ? 377  GLY A O   1 
ATOM   3182 N N   A SER A 1 297 ? 22.92030  -20.56583 -31.27923 0.537 9.33398  ? 378  SER A N   1 
ATOM   3183 N N   B SER A 1 297 ? 22.84879  -20.87976 -31.19399 0.463 9.96947  ? 378  SER A N   1 
ATOM   3184 C CA  A SER A 1 297 ? 24.30049  -20.25143 -30.92062 0.537 10.21788 ? 378  SER A CA  1 
ATOM   3185 C CA  B SER A 1 297 ? 24.18634  -20.38983 -30.89812 0.463 9.70688  ? 378  SER A CA  1 
ATOM   3186 C C   A SER A 1 297 ? 24.85551  -21.25242 -29.91924 0.537 9.27164  ? 378  SER A C   1 
ATOM   3187 C C   B SER A 1 297 ? 24.84921  -21.30722 -29.88694 0.463 9.16413  ? 378  SER A C   1 
ATOM   3188 O O   A SER A 1 297 ? 24.19539  -21.58092 -28.92995 0.537 9.34569  ? 378  SER A O   1 
ATOM   3189 O O   B SER A 1 297 ? 24.24195  -21.65733 -28.86917 0.463 9.67212  ? 378  SER A O   1 
ATOM   3190 C CB  A SER A 1 297 ? 24.40690  -18.86465 -30.27739 0.537 10.00083 ? 378  SER A CB  1 
ATOM   3191 C CB  B SER A 1 297 ? 24.13956  -18.96390 -30.34368 0.463 10.34744 ? 378  SER A CB  1 
ATOM   3192 O OG  A SER A 1 297 ? 25.71127  -18.63938 -29.76246 0.537 9.02540  ? 378  SER A OG  1 
ATOM   3193 O OG  B SER A 1 297 ? 25.32157  -18.66111 -29.62925 0.463 10.04175 ? 378  SER A OG  1 
ATOM   3194 N N   . GLN A 1 298 ? 26.10646  -21.66502 -30.15734 1.000 9.35766  ? 379  GLN A N   1 
ATOM   3195 C CA  . GLN A 1 298 ? 26.86396  -22.47152 -29.21307 1.000 9.47257  ? 379  GLN A CA  1 
ATOM   3196 C C   . GLN A 1 298 ? 26.93542  -21.83192 -27.83464 1.000 8.72553  ? 379  GLN A C   1 
ATOM   3197 O O   . GLN A 1 298 ? 27.08954  -22.53982 -26.83479 1.000 10.81030 ? 379  GLN A O   1 
ATOM   3198 C CB  . GLN A 1 298 ? 28.27722  -22.68815 -29.75593 1.000 10.09656 ? 379  GLN A CB  1 
ATOM   3199 C CG  . GLN A 1 298 ? 29.11019  -21.41870 -29.90013 1.000 12.12354 ? 379  GLN A CG  1 
ATOM   3200 C CD  . GLN A 1 298 ? 30.50669  -21.71001 -30.36898 1.000 13.73976 ? 379  GLN A CD  1 
ATOM   3201 O OE1 . GLN A 1 298 ? 31.27381  -22.37442 -29.67235 1.000 17.72883 ? 379  GLN A OE1 1 
ATOM   3202 N NE2 . GLN A 1 298 ? 30.86730  -21.17909 -31.53383 1.000 17.32925 ? 379  GLN A NE2 1 
ATOM   3203 N N   . PHE A 1 299 ? 26.84340  -20.50463 -27.75370 1.000 8.04704  ? 380  PHE A N   1 
ATOM   3204 C CA  . PHE A 1 299 ? 27.05053  -19.80326 -26.49818 1.000 7.65608  ? 380  PHE A CA  1 
ATOM   3205 C C   . PHE A 1 299 ? 25.78708  -19.61677 -25.67578 1.000 7.64058  ? 380  PHE A C   1 
ATOM   3206 O O   . PHE A 1 299 ? 25.88872  -19.22548 -24.50851 1.000 8.36394  ? 380  PHE A O   1 
ATOM   3207 C CB  . PHE A 1 299 ? 27.66163  -18.42036 -26.76268 1.000 8.54209  ? 380  PHE A CB  1 
ATOM   3208 C CG  . PHE A 1 299 ? 28.95519  -18.46485 -27.50733 1.000 9.46357  ? 380  PHE A CG  1 
ATOM   3209 C CD1 . PHE A 1 299 ? 30.04290  -19.15863 -27.00444 1.000 11.21986 ? 380  PHE A CD1 1 
ATOM   3210 C CD2 . PHE A 1 299 ? 29.08918  -17.80228 -28.72293 1.000 10.63441 ? 380  PHE A CD2 1 
ATOM   3211 C CE1 . PHE A 1 299 ? 31.24404  -19.18734 -27.70084 1.000 12.90872 ? 380  PHE A CE1 1 
ATOM   3212 C CE2 . PHE A 1 299 ? 30.28260  -17.83860 -29.42556 1.000 12.18864 ? 380  PHE A CE2 1 
ATOM   3213 C CZ  . PHE A 1 299 ? 31.35945  -18.53140 -28.91135 1.000 14.01408 ? 380  PHE A CZ  1 
ATOM   3214 N N   . ILE A 1 300 ? 24.60861  -19.83233 -26.25297 1.000 7.75013  ? 381  ILE A N   1 
ATOM   3215 C CA  . ILE A 1 300 ? 23.35397  -19.40889 -25.63749 1.000 7.66594  ? 381  ILE A CA  1 
ATOM   3216 C C   . ILE A 1 300 ? 22.56627  -20.64054 -25.20077 1.000 6.97181  ? 381  ILE A C   1 
ATOM   3217 O O   . ILE A 1 300 ? 22.13266  -21.44769 -26.03353 1.000 8.17917  ? 381  ILE A O   1 
ATOM   3218 C CB  . ILE A 1 300 ? 22.53713  -18.48598 -26.55595 1.000 8.27162  ? 381  ILE A CB  1 
ATOM   3219 C CG1 . ILE A 1 300 ? 23.39374  -17.30324 -27.04347 1.000 8.54969  ? 381  ILE A CG1 1 
ATOM   3220 C CG2 . ILE A 1 300 ? 21.30258  -17.98541 -25.82440 1.000 8.74831  ? 381  ILE A CG2 1 
ATOM   3221 C CD1 . ILE A 1 300 ? 22.67182  -16.36791 -27.98593 1.000 9.77759  ? 381  ILE A CD1 1 
ATOM   3222 N N   A ASP A 1 301 ? 22.37281  -20.76334 -23.88884 0.865 6.74550  ? 382  ASP A N   1 
ATOM   3223 N N   B ASP A 1 301 ? 22.38689  -20.77756 -23.88416 0.135 6.79565  ? 382  ASP A N   1 
ATOM   3224 C CA  A ASP A 1 301 ? 21.59828  -21.87112 -23.33061 0.865 6.93794  ? 382  ASP A CA  1 
ATOM   3225 C CA  B ASP A 1 301 ? 21.59073  -21.87353 -23.34129 0.135 6.99701  ? 382  ASP A CA  1 
ATOM   3226 C C   A ASP A 1 301 ? 20.09916  -21.69037 -23.55552 0.865 6.93288  ? 382  ASP A C   1 
ATOM   3227 C C   B ASP A 1 301 ? 20.10703  -21.68127 -23.63216 0.135 6.98751  ? 382  ASP A C   1 
ATOM   3228 O O   A ASP A 1 301 ? 19.37722  -22.67123 -23.75887 0.865 7.41332  ? 382  ASP A O   1 
ATOM   3229 O O   B ASP A 1 301 ? 19.41249  -22.63724 -23.99303 0.135 7.75183  ? 382  ASP A O   1 
ATOM   3230 C CB  A ASP A 1 301 ? 21.85407  -21.99042 -21.82854 0.865 7.31700  ? 382  ASP A CB  1 
ATOM   3231 C CB  B ASP A 1 301 ? 21.81581  -21.97984 -21.83224 0.135 7.36919  ? 382  ASP A CB  1 
ATOM   3232 C CG  A ASP A 1 301 ? 23.26507  -22.41408 -21.49558 0.865 6.92967  ? 382  ASP A CG  1 
ATOM   3233 C CG  B ASP A 1 301 ? 23.09895  -22.70071 -21.47447 0.135 7.84231  ? 382  ASP A CG  1 
ATOM   3234 O OD1 A ASP A 1 301 ? 23.93207  -23.03593 -22.36128 0.865 8.01557  ? 382  ASP A OD1 1 
ATOM   3235 O OD1 B ASP A 1 301 ? 23.66235  -23.40418 -22.33800 0.135 7.01568  ? 382  ASP A OD1 1 
ATOM   3236 O OD2 A ASP A 1 301 ? 23.69037  -22.13271 -20.34771 0.865 7.81266  ? 382  ASP A OD2 1 
ATOM   3237 O OD2 B ASP A 1 301 ? 23.55365  -22.55445 -20.32245 0.135 8.05363  ? 382  ASP A OD2 1 
ATOM   3238 N N   . SER A 1 302 ? 19.59982  -20.46053 -23.47842 1.000 6.91363  ? 383  SER A N   1 
ATOM   3239 C CA  . SER A 1 302 ? 18.17462  -20.22754 -23.65017 1.000 7.09693  ? 383  SER A CA  1 
ATOM   3240 C C   . SER A 1 302 ? 17.89277  -18.77985 -24.02333 1.000 6.69557  ? 383  SER A C   1 
ATOM   3241 O O   . SER A 1 302 ? 18.51992  -17.85240 -23.50293 1.000 7.25765  ? 383  SER A O   1 
ATOM   3242 C CB  . SER A 1 302 ? 17.39571  -20.58504 -22.37781 1.000 7.48735  ? 383  SER A CB  1 
ATOM   3243 O OG  . SER A 1 302 ? 16.00286  -20.71601 -22.63841 1.000 7.78258  ? 383  SER A OG  1 
ATOM   3244 N N   . ILE A 1 303 ? 16.91417  -18.61438 -24.90354 1.000 6.77699  ? 384  ILE A N   1 
ATOM   3245 C CA  . ILE A 1 303 ? 16.13312  -17.39333 -24.98223 1.000 6.99203  ? 384  ILE A CA  1 
ATOM   3246 C C   . ILE A 1 303 ? 15.13421  -17.45627 -23.83926 1.000 6.48418  ? 384  ILE A C   1 
ATOM   3247 O O   . ILE A 1 303 ? 14.54787  -18.51231 -23.58406 1.000 7.03305  ? 384  ILE A O   1 
ATOM   3248 C CB  . ILE A 1 303 ? 15.44859  -17.29680 -26.35859 1.000 7.29506  ? 384  ILE A CB  1 
ATOM   3249 C CG1 . ILE A 1 303 ? 16.50468  -17.17676 -27.46370 1.000 8.55421  ? 384  ILE A CG1 1 
ATOM   3250 C CG2 . ILE A 1 303 ? 14.46819  -16.13289 -26.40076 1.000 8.39491  ? 384  ILE A CG2 1 
ATOM   3251 C CD1 . ILE A 1 303 ? 15.97426  -17.36691 -28.85834 1.000 10.31728 ? 384  ILE A CD1 1 
ATOM   3252 N N   . VAL A 1 304 ? 14.96039  -16.33963 -23.12559 1.000 6.85200  ? 385  VAL A N   1 
ATOM   3253 C CA  . VAL A 1 304 ? 14.14268  -16.29282 -21.92008 1.000 6.97765  ? 385  VAL A CA  1 
ATOM   3254 C C   . VAL A 1 304 ? 13.29544  -15.02315 -21.94681 1.000 6.56686  ? 385  VAL A C   1 
ATOM   3255 O O   . VAL A 1 304 ? 13.55530  -14.09776 -22.71870 1.000 6.76714  ? 385  VAL A O   1 
ATOM   3256 C CB  . VAL A 1 304 ? 15.02436  -16.34895 -20.64818 1.000 7.21875  ? 385  VAL A CB  1 
ATOM   3257 C CG1 . VAL A 1 304 ? 15.62256  -17.73463 -20.45880 1.000 7.83407  ? 385  VAL A CG1 1 
ATOM   3258 C CG2 . VAL A 1 304 ? 16.13845  -15.29246 -20.71563 1.000 7.76087  ? 385  VAL A CG2 1 
ATOM   3259 N N   . TRP A 1 305 ? 12.28732  -14.98660 -21.07347 1.000 6.68507  ? 386  TRP A N   1 
ATOM   3260 C CA  . TRP A 1 305 ? 11.51760  -13.77576 -20.79822 1.000 7.00592  ? 386  TRP A CA  1 
ATOM   3261 C C   . TRP A 1 305 ? 11.82272  -13.41120 -19.34984 1.000 6.45376  ? 386  TRP A C   1 
ATOM   3262 O O   . TRP A 1 305 ? 11.21623  -13.94515 -18.41394 1.000 7.34868  ? 386  TRP A O   1 
ATOM   3263 C CB  . TRP A 1 305 ? 10.02849  -13.99906 -21.01592 1.000 7.20568  ? 386  TRP A CB  1 
ATOM   3264 C CG  . TRP A 1 305 ? 9.59041   -13.97839 -22.45355 1.000 7.22269  ? 386  TRP A CG  1 
ATOM   3265 C CD1 . TRP A 1 305 ? 10.36474  -14.14654 -23.57388 1.000 7.51396  ? 386  TRP A CD1 1 
ATOM   3266 C CD2 . TRP A 1 305 ? 8.25257   -13.80624 -22.91768 1.000 7.35373  ? 386  TRP A CD2 1 
ATOM   3267 N NE1 . TRP A 1 305 ? 9.58526   -14.06359 -24.69845 1.000 7.74271  ? 386  TRP A NE1 1 
ATOM   3268 C CE2 . TRP A 1 305 ? 8.28318   -13.85437 -24.32088 1.000 8.09837  ? 386  TRP A CE2 1 
ATOM   3269 C CE3 . TRP A 1 305 ? 7.02534   -13.59321 -22.27636 1.000 8.30943  ? 386  TRP A CE3 1 
ATOM   3270 C CZ2 . TRP A 1 305 ? 7.13247   -13.69726 -25.09480 1.000 9.01655  ? 386  TRP A CZ2 1 
ATOM   3271 C CZ3 . TRP A 1 305 ? 5.88525   -13.44539 -23.04219 1.000 9.62400  ? 386  TRP A CZ3 1 
ATOM   3272 C CH2 . TRP A 1 305 ? 5.94630   -13.49153 -24.43392 1.000 9.76162  ? 386  TRP A CH2 1 
ATOM   3273 N N   . VAL A 1 306 ? 12.80398  -12.52656 -19.16620 1.000 7.40171  ? 387  VAL A N   1 
ATOM   3274 C CA  . VAL A 1 306 ? 13.22075  -12.17254 -17.81150 1.000 7.42274  ? 387  VAL A CA  1 
ATOM   3275 C C   . VAL A 1 306 ? 12.30840  -11.10946 -17.22727 1.000 7.34746  ? 387  VAL A C   1 
ATOM   3276 O O   . VAL A 1 306 ? 11.66071  -11.33897 -16.20204 1.000 8.27578  ? 387  VAL A O   1 
ATOM   3277 C CB  . VAL A 1 306 ? 14.70307  -11.77886 -17.71966 1.000 7.59477  ? 387  VAL A CB  1 
ATOM   3278 C CG1 . VAL A 1 306 ? 15.07969  -11.61849 -16.25324 1.000 7.68978  ? 387  VAL A CG1 1 
ATOM   3279 C CG2 . VAL A 1 306 ? 15.57975  -12.83375 -18.35802 1.000 8.01825  ? 387  VAL A CG2 1 
ATOM   3280 N N   . LYS A 1 307 ? 12.22642  -9.94407  -17.86525 1.000 7.93730  ? 388  LYS A N   1 
ATOM   3281 C CA  A LYS A 1 307 ? 11.26630  -8.92018  -17.45474 0.601 8.49815  ? 388  LYS A CA  1 
ATOM   3282 C CA  B LYS A 1 307 ? 11.26754  -8.93738  -17.43908 0.399 8.51642  ? 388  LYS A CA  1 
ATOM   3283 C C   . LYS A 1 307 ? 9.87503   -9.31706  -17.93097 1.000 8.10248  ? 388  LYS A C   1 
ATOM   3284 O O   . LYS A 1 307 ? 9.66092   -9.42067  -19.14258 1.000 8.66000  ? 388  LYS A O   1 
ATOM   3285 C CB  A LYS A 1 307 ? 11.64931  -7.58597  -18.09120 0.601 9.56216  ? 388  LYS A CB  1 
ATOM   3286 C CB  B LYS A 1 307 ? 11.65715  -7.56149  -17.96476 0.399 9.39629  ? 388  LYS A CB  1 
ATOM   3287 C CG  A LYS A 1 307 ? 10.58796  -6.48102  -18.04576 0.601 13.21669 ? 388  LYS A CG  1 
ATOM   3288 C CG  B LYS A 1 307 ? 10.68142  -6.45409  -17.59532 0.399 10.04508 ? 388  LYS A CG  1 
ATOM   3289 C CD  A LYS A 1 307 ? 10.37644  -5.90629  -16.65618 0.601 15.23153 ? 388  LYS A CD  1 
ATOM   3290 C CD  B LYS A 1 307 ? 10.47816  -6.34483  -16.09395 0.399 15.86330 ? 388  LYS A CD  1 
ATOM   3291 C CE  A LYS A 1 307 ? 9.68172   -4.54405  -16.71593 0.601 17.07054 ? 388  LYS A CE  1 
ATOM   3292 C CE  B LYS A 1 307 ? 11.62435  -5.60843  -15.42526 0.399 15.31283 ? 388  LYS A CE  1 
ATOM   3293 N NZ  A LYS A 1 307 ? 8.26434   -4.62776  -17.16998 0.601 18.31724 ? 388  LYS A NZ  1 
ATOM   3294 N NZ  B LYS A 1 307 ? 11.18552  -4.89419  -14.19320 0.399 16.98277 ? 388  LYS A NZ  1 
ATOM   3295 N N   . PRO A 1 308 ? 8.91263   -9.55686  -17.03833 1.000 9.55946  ? 389  PRO A N   1 
ATOM   3296 C CA  . PRO A 1 308 ? 7.54611   -9.85192  -17.49320 1.000 10.37990 ? 389  PRO A CA  1 
ATOM   3297 C C   . PRO A 1 308 ? 6.90589   -8.59589  -18.06646 1.000 10.17245 ? 389  PRO A C   1 
ATOM   3298 O O   . PRO A 1 308 ? 6.92399   -7.53165  -17.44756 1.000 15.00550 ? 389  PRO A O   1 
ATOM   3299 C CB  . PRO A 1 308 ? 6.82591   -10.31808 -16.22065 1.000 12.30571 ? 389  PRO A CB  1 
ATOM   3300 C CG  . PRO A 1 308 ? 7.75640   -10.07965 -15.08542 1.000 15.19590 ? 389  PRO A CG  1 
ATOM   3301 C CD  . PRO A 1 308 ? 9.02171   -9.48596  -15.57290 1.000 12.89645 ? 389  PRO A CD  1 
ATOM   3302 N N   A GLY A 1 309 ? 6.32092   -8.72661  -19.25338 0.652 10.10319 ? 390  GLY A N   1 
ATOM   3303 N N   B GLY A 1 309 ? 6.35168   -8.72734  -19.26740 0.348 10.17217 ? 390  GLY A N   1 
ATOM   3304 C CA  A GLY A 1 309 ? 5.76977   -7.57258  -19.94745 0.652 10.54005 ? 390  GLY A CA  1 
ATOM   3305 C CA  B GLY A 1 309 ? 5.76628   -7.58465  -19.94491 0.348 10.53039 ? 390  GLY A CA  1 
ATOM   3306 C C   A GLY A 1 309 ? 4.40213   -7.17303  -19.41906 0.652 10.19231 ? 390  GLY A C   1 
ATOM   3307 C C   B GLY A 1 309 ? 4.39474   -7.23808  -19.38918 0.348 10.14964 ? 390  GLY A C   1 
ATOM   3308 O O   A GLY A 1 309 ? 3.51576   -8.01743  -19.24280 0.652 10.65610 ? 390  GLY A O   1 
ATOM   3309 O O   B GLY A 1 309 ? 3.60840   -8.10718  -19.01064 0.348 12.05458 ? 390  GLY A O   1 
ATOM   3310 N N   A GLY A 1 310 ? 4.22197   -5.87152  -19.19747 0.652 10.60791 ? 391  GLY A N   1 
ATOM   3311 N N   B GLY A 1 310 ? 4.10868   -5.94312  -19.35840 0.348 10.26263 ? 391  GLY A N   1 
ATOM   3312 C CA  A GLY A 1 310 ? 2.98190   -5.30440  -18.69735 0.652 10.73096 ? 391  GLY A CA  1 
ATOM   3313 C CA  B GLY A 1 310 ? 2.83487   -5.44334  -18.87887 0.348 10.52458 ? 391  GLY A CA  1 
ATOM   3314 C C   A GLY A 1 310 ? 3.12120   -4.58534  -17.37409 0.652 10.40126 ? 391  GLY A C   1 
ATOM   3315 C C   B GLY A 1 310 ? 2.92273   -4.53055  -17.67608 0.348 10.65410 ? 391  GLY A C   1 
ATOM   3316 O O   A GLY A 1 310 ? 2.23206   -3.80561  -17.00472 0.652 13.97304 ? 391  GLY A O   1 
ATOM   3317 O O   B GLY A 1 310 ? 1.92852   -3.86372  -17.35813 0.348 12.21029 ? 391  GLY A O   1 
ATOM   3318 N N   A GLU A 1 311 ? 4.20582   -4.82917  -16.64472 0.652 12.01063 ? 392  GLU A N   1 
ATOM   3319 N N   B GLU A 1 311 ? 4.05581   -4.46995  -16.98295 0.348 11.28553 ? 392  GLU A N   1 
ATOM   3320 C CA  A GLU A 1 311 ? 4.47687   -4.16058  -15.37896 0.652 15.37401 ? 392  GLU A CA  1 
ATOM   3321 C CA  B GLU A 1 311 ? 4.25320   -3.52810  -15.89284 0.348 13.43333 ? 392  GLU A CA  1 
ATOM   3322 C C   A GLU A 1 311 ? 5.29547   -2.90192  -15.66631 0.652 14.71157 ? 392  GLU A C   1 
ATOM   3323 C C   B GLU A 1 311 ? 4.82046   -2.22185  -16.42968 0.348 12.45747 ? 392  GLU A C   1 
ATOM   3324 O O   A GLU A 1 311 ? 6.36772   -2.98389  -16.27480 0.652 15.61450 ? 392  GLU A O   1 
ATOM   3325 O O   B GLU A 1 311 ? 5.38026   -2.16532  -17.52569 0.348 11.44163 ? 392  GLU A O   1 
ATOM   3326 C CB  A GLU A 1 311 ? 5.21488   -5.12381  -14.44034 0.652 13.54513 ? 392  GLU A CB  1 
ATOM   3327 C CB  B GLU A 1 311 ? 5.25222   -4.09039  -14.88546 0.348 14.46151 ? 392  GLU A CB  1 
ATOM   3328 C CG  A GLU A 1 311 ? 4.48037   -6.45970  -14.20853 0.652 14.82867 ? 392  GLU A CG  1 
ATOM   3329 C CG  B GLU A 1 311 ? 4.64567   -4.55905  -13.58779 0.348 17.47315 ? 392  GLU A CG  1 
ATOM   3330 C CD  A GLU A 1 311 ? 5.30125   -7.49279  -13.43990 0.652 16.78207 ? 392  GLU A CD  1 
ATOM   3331 C CD  B GLU A 1 311 ? 5.59652   -5.44231  -12.81424 0.348 19.31057 ? 392  GLU A CD  1 
ATOM   3332 O OE1 A GLU A 1 311 ? 6.45014   -7.18845  -13.05704 0.652 15.03740 ? 392  GLU A OE1 1 
ATOM   3333 O OE1 B GLU A 1 311 ? 6.34310   -6.20805  -13.45763 0.348 18.67266 ? 392  GLU A OE1 1 
ATOM   3334 O OE2 A GLU A 1 311 ? 4.78832   -8.61264  -13.20329 0.652 13.26289 ? 392  GLU A OE2 1 
ATOM   3335 O OE2 B GLU A 1 311 ? 5.59881   -5.37397  -11.56868 0.348 20.74000 ? 392  GLU A OE2 1 
ATOM   3336 N N   A SER A 1 312 ? 4.77989   -1.73887  -15.26055 0.652 14.58341 ? 393  SER A N   1 
ATOM   3337 N N   B SER A 1 312 ? 4.68163   -1.16605  -15.63316 0.348 10.69067 ? 393  SER A N   1 
ATOM   3338 C CA  A SER A 1 312 ? 5.43518   -0.47819  -15.59588 0.652 13.62352 ? 393  SER A CA  1 
ATOM   3339 C CA  B SER A 1 312 ? 5.36311   0.08309   -15.93003 0.348 10.40658 ? 393  SER A CA  1 
ATOM   3340 C C   A SER A 1 312 ? 6.82101   -0.40301  -14.97123 0.652 12.15495 ? 393  SER A C   1 
ATOM   3341 C C   B SER A 1 312 ? 6.77503   0.04634   -15.36611 0.348 12.87315 ? 393  SER A C   1 
ATOM   3342 O O   A SER A 1 312 ? 7.05503   -0.88833  -13.86154 0.652 13.49478 ? 393  SER A O   1 
ATOM   3343 O O   B SER A 1 312 ? 7.00304   -0.42580  -14.24842 0.348 13.04677 ? 393  SER A O   1 
ATOM   3344 C CB  A SER A 1 312 ? 4.61395   0.71597   -15.10634 0.652 13.96500 ? 393  SER A CB  1 
ATOM   3345 C CB  B SER A 1 312 ? 4.61469   1.26413   -15.31991 0.348 11.48127 ? 393  SER A CB  1 
ATOM   3346 O OG  A SER A 1 312 ? 5.35943   1.91796   -15.24629 0.652 14.43722 ? 393  SER A OG  1 
ATOM   3347 O OG  B SER A 1 312 ? 5.35004   2.45876   -15.52098 0.348 12.35952 ? 393  SER A OG  1 
ATOM   3348 N N   A ALA A 1 313 ? 7.74083   0.23960   -15.69201 0.652 12.56994 ? 394  ALA A N   1 
ATOM   3349 N N   B ALA A 1 313 ? 7.72571   0.54885   -16.14700 0.348 13.31108 ? 394  ALA A N   1 
ATOM   3350 C CA  A ALA A 1 313 ? 9.10102   0.44702   -15.21779 0.652 12.77899 ? 394  ALA A CA  1 
ATOM   3351 C CA  B ALA A 1 313 ? 9.10340   0.66364   -15.69250 0.348 12.05945 ? 394  ALA A CA  1 
ATOM   3352 C C   A ALA A 1 313 ? 9.31542   1.80922   -14.57238 0.652 13.37943 ? 394  ALA A C   1 
ATOM   3353 C C   B ALA A 1 313 ? 9.35558   1.93778   -14.90476 0.348 13.20319 ? 394  ALA A C   1 
ATOM   3354 O O   A ALA A 1 313 ? 10.40666  2.06482   -14.05115 0.652 13.39722 ? 394  ALA A O   1 
ATOM   3355 O O   B ALA A 1 313 ? 10.50843  2.22851   -14.56983 0.348 13.47884 ? 394  ALA A O   1 
ATOM   3356 C CB  A ALA A 1 313 ? 10.09716  0.27067   -16.36789 0.652 14.41325 ? 394  ALA A CB  1 
ATOM   3357 C CB  B ALA A 1 313 ? 10.06236  0.59292   -16.87987 0.348 14.12049 ? 394  ALA A CB  1 
ATOM   3358 N N   . GLY A 1 314 ? 8.31753   2.68744   -14.60101 1.000 13.87714 ? 395  GLY A N   1 
ATOM   3359 C CA  . GLY A 1 314 ? 8.44689   3.96841   -13.94516 1.000 14.55056 ? 395  GLY A CA  1 
ATOM   3360 C C   . GLY A 1 314 ? 7.33105   4.89692   -14.35946 1.000 14.38630 ? 395  GLY A C   1 
ATOM   3361 O O   . GLY A 1 314 ? 6.82399   4.83665   -15.48265 1.000 14.71896 ? 395  GLY A O   1 
ATOM   3362 N N   . THR A 1 315 ? 6.94145   5.77453   -13.44399 1.000 13.72592 ? 396  THR A N   1 
ATOM   3363 C CA  . THR A 1 315 ? 5.89887   6.74162   -13.73481 1.000 13.62653 ? 396  THR A CA  1 
ATOM   3364 C C   . THR A 1 315 ? 6.40807   7.81347   -14.69146 1.000 15.66442 ? 396  THR A C   1 
ATOM   3365 O O   . THR A 1 315 ? 7.59318   8.15822   -14.70572 1.000 15.34963 ? 396  THR A O   1 
ATOM   3366 C CB  . THR A 1 315 ? 5.41679   7.39651   -12.44051 1.000 16.58027 ? 396  THR A CB  1 
ATOM   3367 O OG1 . THR A 1 315 ? 4.38529   8.34097   -12.74343 1.000 17.34833 ? 396  THR A OG1 1 
ATOM   3368 C CG2 . THR A 1 315 ? 6.56118   8.10440   -11.72843 1.000 18.73629 ? 396  THR A CG2 1 
ATOM   3369 N N   . SER A 1 316 ? 5.49346   8.34073   -15.50104 1.000 14.94131 ? 397  SER A N   1 
ATOM   3370 C CA  . SER A 1 316 ? 5.76328   9.52486   -16.30597 1.000 14.83981 ? 397  SER A CA  1 
ATOM   3371 C C   . SER A 1 316 ? 5.39824   10.81784  -15.58330 1.000 17.64292 ? 397  SER A C   1 
ATOM   3372 O O   . SER A 1 316 ? 5.63357   11.90507  -16.12324 1.000 17.65774 ? 397  SER A O   1 
ATOM   3373 C CB  . SER A 1 316 ? 5.01677   9.43680   -17.64101 1.000 15.98593 ? 397  SER A CB  1 
ATOM   3374 O OG  . SER A 1 316 ? 3.62056   9.30451   -17.43951 1.000 17.47242 ? 397  SER A OG  1 
ATOM   3375 N N   . ASN A 1 317 ? 4.84199   10.71358  -14.37726 1.000 15.12000 ? 398  ASN A N   1 
ATOM   3376 C CA  . ASN A 1 317 ? 4.41423   11.85387  -13.56725 1.000 18.03447 ? 398  ASN A CA  1 
ATOM   3377 C C   . ASN A 1 317 ? 5.63839   12.53753  -12.97085 1.000 18.49117 ? 398  ASN A C   1 
ATOM   3378 O O   . ASN A 1 317 ? 6.28240   11.99273  -12.07025 1.000 17.70828 ? 398  ASN A O   1 
ATOM   3379 C CB  . ASN A 1 317 ? 3.52160   11.32997  -12.44621 1.000 16.65601 ? 398  ASN A CB  1 
ATOM   3380 C CG  . ASN A 1 317 ? 2.97149   12.42678  -11.54470 1.000 26.24554 ? 398  ASN A CG  1 
ATOM   3381 O OD1 . ASN A 1 317 ? 3.32106   13.60575  -11.66307 1.000 20.33210 ? 398  ASN A OD1 1 
ATOM   3382 N ND2 . ASN A 1 317 ? 2.12072   12.02106  -10.60595 1.000 32.23967 ? 398  ASN A ND2 1 
ATOM   3383 N N   . SER A 1 318 ? 5.93317   13.75457  -13.42991 1.000 17.96800 ? 399  SER A N   1 
ATOM   3384 C CA  . SER A 1 318 ? 7.12107   14.45641  -12.95585 1.000 21.50993 ? 399  SER A CA  1 
ATOM   3385 C C   . SER A 1 318 ? 7.01266   14.93105  -11.50998 1.000 23.42723 ? 399  SER A C   1 
ATOM   3386 O O   . SER A 1 318 ? 8.00144   15.44566  -10.97692 1.000 25.55616 ? 399  SER A O   1 
ATOM   3387 C CB  . SER A 1 318 ? 7.47259   15.61941  -13.88677 1.000 21.69690 ? 399  SER A CB  1 
ATOM   3388 O OG  . SER A 1 318 ? 6.37582   16.49887  -14.05325 1.000 22.62899 ? 399  SER A OG  1 
ATOM   3389 N N   . SER A 1 319 ? 5.85526   14.77069  -10.86491 1.000 24.31286 ? 400  SER A N   1 
ATOM   3390 C CA  . SER A 1 319 ? 5.68412   15.13842  -9.46415  1.000 25.20653 ? 400  SER A CA  1 
ATOM   3391 C C   . SER A 1 319 ? 5.91740   13.97986  -8.50580  1.000 27.80418 ? 400  SER A C   1 
ATOM   3392 O O   . SER A 1 319 ? 5.93716   14.19769  -7.28982  1.000 29.38627 ? 400  SER A O   1 
ATOM   3393 C CB  . SER A 1 319 ? 4.27755   15.69531  -9.22290  1.000 27.53587 ? 400  SER A CB  1 
ATOM   3394 O OG  . SER A 1 319 ? 4.03012   16.82546  -10.03331 1.000 27.48810 ? 400  SER A OG  1 
ATOM   3395 N N   . SER A 1 320 ? 6.08216   12.76603  -9.01447  1.000 23.08035 ? 401  SER A N   1 
ATOM   3396 C CA  . SER A 1 320 ? 6.29252   11.62209  -8.14476  1.000 24.78592 ? 401  SER A CA  1 
ATOM   3397 C C   . SER A 1 320 ? 7.67206   11.69832  -7.49519  1.000 23.33998 ? 401  SER A C   1 
ATOM   3398 O O   . SER A 1 320 ? 8.64261   12.10278  -8.14284  1.000 23.30211 ? 401  SER A O   1 
ATOM   3399 C CB  . SER A 1 320 ? 6.20358   10.33512  -8.95726  1.000 25.04281 ? 401  SER A CB  1 
ATOM   3400 O OG  . SER A 1 320 ? 6.41271   9.20395   -8.13276  1.000 24.23471 ? 401  SER A OG  1 
ATOM   3401 N N   . PRO A 1 321 ? 7.79486   11.30444  -6.22532  1.000 26.89269 ? 402  PRO A N   1 
ATOM   3402 C CA  . PRO A 1 321 ? 9.13038   11.21217  -5.61711  1.000 30.37571 ? 402  PRO A CA  1 
ATOM   3403 C C   . PRO A 1 321 ? 10.02251  10.18685  -6.29150  1.000 32.01304 ? 402  PRO A C   1 
ATOM   3404 O O   . PRO A 1 321 ? 11.25124  10.29257  -6.19214  1.000 28.19935 ? 402  PRO A O   1 
ATOM   3405 C CB  . PRO A 1 321 ? 8.83012   10.82675  -4.16214  1.000 32.24992 ? 402  PRO A CB  1 
ATOM   3406 C CG  . PRO A 1 321 ? 7.50673   10.13417  -4.22842  1.000 32.30843 ? 402  PRO A CG  1 
ATOM   3407 C CD  . PRO A 1 321 ? 6.73593   10.84494  -5.30999  1.000 29.14864 ? 402  PRO A CD  1 
ATOM   3408 N N   . ARG A 1 322 ? 9.44403   9.20445   -6.98264  1.000 26.76670 ? 403  ARG A N   1 
ATOM   3409 C CA  . ARG A 1 322 ? 10.19508  8.16036   -7.66466  1.000 22.52974 ? 403  ARG A CA  1 
ATOM   3410 C C   . ARG A 1 322 ? 10.37581  8.44548   -9.15230  1.000 24.03486 ? 403  ARG A C   1 
ATOM   3411 O O   . ARG A 1 322 ? 10.70319  7.53160   -9.91648  1.000 19.94401 ? 403  ARG A O   1 
ATOM   3412 C CB  . ARG A 1 322 ? 9.51501   6.80640   -7.45571  1.000 26.60803 ? 403  ARG A CB  1 
ATOM   3413 C CG  . ARG A 1 322 ? 9.14643   6.52808   -6.00769  1.000 33.71322 ? 403  ARG A CG  1 
ATOM   3414 C CD  . ARG A 1 322 ? 10.12197  5.55249   -5.36315  1.000 36.20146 ? 403  ARG A CD  1 
ATOM   3415 N NE  . ARG A 1 322 ? 11.47935  6.08142   -5.27748  1.000 35.36641 ? 403  ARG A NE  1 
ATOM   3416 C CZ  . ARG A 1 322 ? 11.86432  7.04775   -4.45399  1.000 39.13360 ? 403  ARG A CZ  1 
ATOM   3417 N NH1 . ARG A 1 322 ? 11.02016  7.61074   -3.60371  1.000 40.70275 ? 403  ARG A NH1 1 
ATOM   3418 N NH2 . ARG A 1 322 ? 13.13002  7.45715   -4.48110  1.000 32.79870 ? 403  ARG A NH2 1 
ATOM   3419 N N   . TYR A 1 323 ? 10.18522  9.69405   -9.57160  1.000 19.89274 ? 404  TYR A N   1 
ATOM   3420 C CA  . TYR A 1 323 ? 10.17274  10.02796  -10.98977 1.000 18.17187 ? 404  TYR A CA  1 
ATOM   3421 C C   . TYR A 1 323 ? 11.57563  9.98374   -11.58246 1.000 13.81963 ? 404  TYR A C   1 
ATOM   3422 O O   . TYR A 1 323 ? 12.51374  10.58218  -11.04438 1.000 16.26341 ? 404  TYR A O   1 
ATOM   3423 C CB  . TYR A 1 323 ? 9.57818   11.41915  -11.17388 1.000 18.71949 ? 404  TYR A CB  1 
ATOM   3424 C CG  . TYR A 1 323 ? 9.65928   11.98265  -12.57190 1.000 17.01404 ? 404  TYR A CG  1 
ATOM   3425 C CD1 . TYR A 1 323 ? 8.93140   11.42103  -13.61343 1.000 15.68957 ? 404  TYR A CD1 1 
ATOM   3426 C CD2 . TYR A 1 323 ? 10.42567  13.10853  -12.84146 1.000 18.51847 ? 404  TYR A CD2 1 
ATOM   3427 C CE1 . TYR A 1 323 ? 8.98388   11.95408  -14.88470 1.000 18.38953 ? 404  TYR A CE1 1 
ATOM   3428 C CE2 . TYR A 1 323 ? 10.48509  13.64530  -14.11127 1.000 16.71157 ? 404  TYR A CE2 1 
ATOM   3429 C CZ  . TYR A 1 323 ? 9.76095   13.06691  -15.12884 1.000 20.15125 ? 404  TYR A CZ  1 
ATOM   3430 O OH  . TYR A 1 323 ? 9.81682   13.60590  -16.39348 1.000 20.85279 ? 404  TYR A OH  1 
ATOM   3431 N N   . ASP A 1 324 ? 11.70125  9.26791   -12.69798 1.000 14.16329 ? 405  ASP A N   1 
ATOM   3432 C CA  . ASP A 1 324 ? 12.89148  9.23222   -13.53735 1.000 14.29298 ? 405  ASP A CA  1 
ATOM   3433 C C   . ASP A 1 324 ? 12.48702  9.81090   -14.88339 1.000 14.04816 ? 405  ASP A C   1 
ATOM   3434 O O   . ASP A 1 324 ? 11.62667  9.24733   -15.56448 1.000 13.99695 ? 405  ASP A O   1 
ATOM   3435 C CB  . ASP A 1 324 ? 13.35042  7.78504   -13.71856 1.000 15.88054 ? 405  ASP A CB  1 
ATOM   3436 C CG  . ASP A 1 324 ? 14.70456  7.67242   -14.38369 1.000 14.28747 ? 405  ASP A CG  1 
ATOM   3437 O OD1 . ASP A 1 324 ? 14.93492  8.36802   -15.39813 1.000 15.81111 ? 405  ASP A OD1 1 
ATOM   3438 O OD2 . ASP A 1 324 ? 15.52509  6.84974   -13.92070 1.000 16.20886 ? 405  ASP A OD2 1 
ATOM   3439 N N   A SER A 1 325 ? 13.12806  10.91329  -15.28031 0.875 15.38063 ? 406  SER A N   1 
ATOM   3440 N N   B SER A 1 325 ? 13.11853  10.91927  -15.27073 0.125 15.32449 ? 406  SER A N   1 
ATOM   3441 C CA  A SER A 1 325 ? 12.71678  11.62673  -16.48784 0.875 14.21998 ? 406  SER A CA  1 
ATOM   3442 C CA  B SER A 1 325 ? 12.68965  11.69979  -16.42906 0.125 14.27072 ? 406  SER A CA  1 
ATOM   3443 C C   A SER A 1 325 ? 12.86891  10.79753  -17.76015 0.875 13.74275 ? 406  SER A C   1 
ATOM   3444 C C   B SER A 1 325 ? 12.79900  10.93728  -17.74654 0.125 13.96737 ? 406  SER A C   1 
ATOM   3445 O O   A SER A 1 325 ? 12.25688  11.13893  -18.77904 0.875 14.38372 ? 406  SER A O   1 
ATOM   3446 O O   B SER A 1 325 ? 12.46813  11.47635  -18.80699 0.125 16.86754 ? 406  SER A O   1 
ATOM   3447 C CB  A SER A 1 325 ? 13.46600  12.95424  -16.61798 0.875 17.14206 ? 406  SER A CB  1 
ATOM   3448 C CB  B SER A 1 325 ? 13.47515  13.00966  -16.50768 0.125 17.49238 ? 406  SER A CB  1 
ATOM   3449 O OG  A SER A 1 325 ? 14.85266  12.74121  -16.79993 0.875 19.30553 ? 406  SER A OG  1 
ATOM   3450 O OG  B SER A 1 325 ? 14.79467  12.78417  -16.96904 0.125 19.34567 ? 406  SER A OG  1 
ATOM   3451 N N   A THR A 1 326 ? 13.66417  9.72134   -17.73403 0.875 13.44612 ? 407  THR A N   1 
ATOM   3452 N N   B THR A 1 326 ? 13.25322  9.68376   -17.69332 0.125 15.65242 ? 407  THR A N   1 
ATOM   3453 C CA  A THR A 1 326 ? 13.70077  8.81245   -18.87720 0.875 13.64418 ? 407  THR A CA  1 
ATOM   3454 C CA  B THR A 1 326 ? 13.36762  8.88112   -18.90258 0.125 14.97863 ? 407  THR A CA  1 
ATOM   3455 C C   A THR A 1 326 ? 12.30056  8.33919   -19.23324 0.875 12.33391 ? 407  THR A C   1 
ATOM   3456 C C   B THR A 1 326 ? 12.01203  8.41190   -19.42291 0.125 13.75157 ? 407  THR A C   1 
ATOM   3457 O O   A THR A 1 326 ? 12.00537  8.08290   -20.40528 0.875 13.47119 ? 407  THR A O   1 
ATOM   3458 O O   B THR A 1 326 ? 11.90208  8.05835   -20.60181 0.125 13.54275 ? 407  THR A O   1 
ATOM   3459 C CB  A THR A 1 326 ? 14.58539  7.60209   -18.56152 0.875 14.07789 ? 407  THR A CB  1 
ATOM   3460 C CB  B THR A 1 326 ? 14.28440  7.68052   -18.64129 0.125 15.40236 ? 407  THR A CB  1 
ATOM   3461 O OG1 A THR A 1 326 ? 15.85841  8.04823   -18.08728 0.875 16.67708 ? 407  THR A OG1 1 
ATOM   3462 O OG1 B THR A 1 326 ? 15.41866  8.10291   -17.87163 0.125 16.86493 ? 407  THR A OG1 1 
ATOM   3463 C CG2 A THR A 1 326 ? 14.78552  6.72414   -19.80047 0.875 15.10039 ? 407  THR A CG2 1 
ATOM   3464 C CG2 B THR A 1 326 ? 14.78616  7.09463   -19.95465 0.125 16.27781 ? 407  THR A CG2 1 
ATOM   3465 N N   A CYS A 1 327 ? 11.41788  8.25195   -18.23831 0.875 11.44630 ? 408  CYS A N   1 
ATOM   3466 N N   B CYS A 1 327 ? 10.97436  8.41596   -18.58418 0.125 14.78503 ? 408  CYS A N   1 
ATOM   3467 C CA  A CYS A 1 327 ? 10.07235  7.72184   -18.40825 0.875 11.54286 ? 408  CYS A CA  1 
ATOM   3468 C CA  B CYS A 1 327 ? 9.66735   7.90123   -18.97675 0.125 14.26984 ? 408  CYS A CA  1 
ATOM   3469 C C   A CYS A 1 327 ? 9.08439   8.73384   -18.97708 0.875 11.84359 ? 408  CYS A C   1 
ATOM   3470 C C   B CYS A 1 327 ? 8.64256   8.97624   -19.33438 0.125 14.37626 ? 408  CYS A C   1 
ATOM   3471 O O   A CYS A 1 327 ? 7.89838   8.40763   -19.10320 0.875 12.40066 ? 408  CYS A O   1 
ATOM   3472 O O   B CYS A 1 327 ? 7.59137   8.63841   -19.89073 0.125 13.15554 ? 408  CYS A O   1 
ATOM   3473 C CB  A CYS A 1 327 ? 9.57247   7.13616   -17.08504 0.875 13.85526 ? 408  CYS A CB  1 
ATOM   3474 C CB  B CYS A 1 327 ? 9.10921   6.92953   -17.92771 0.125 14.28170 ? 408  CYS A CB  1 
ATOM   3475 S SG  A CYS A 1 327 ? 10.60012  5.75088   -16.50676 0.875 12.05623 ? 408  CYS A SG  1 
ATOM   3476 S SG  B CYS A 1 327 ? 10.33958  6.14285   -16.86245 0.125 15.94104 ? 408  CYS A SG  1 
ATOM   3477 N N   A SER A 1 328 ? 9.52720   9.94128   -19.33640 0.875 12.06130 ? 409  SER A N   1 
ATOM   3478 N N   B SER A 1 328 ? 8.90106   10.24369  -19.02748 0.125 16.30037 ? 409  SER A N   1 
ATOM   3479 C CA  A SER A 1 328 ? 8.66123   10.88041  -20.04183 0.875 13.74427 ? 409  SER A CA  1 
ATOM   3480 C CA  B SER A 1 328 ? 8.14006   11.31318  -19.66338 0.125 16.30332 ? 409  SER A CA  1 
ATOM   3481 C C   A SER A 1 328 ? 9.22060   11.31032  -21.39505 0.875 12.99704 ? 409  SER A C   1 
ATOM   3482 C C   B SER A 1 328 ? 8.73358   11.71713  -21.00427 0.125 16.33617 ? 409  SER A C   1 
ATOM   3483 O O   A SER A 1 328 ? 8.69232   12.25081  -22.00229 0.875 13.95464 ? 409  SER A O   1 
ATOM   3484 O O   B SER A 1 328 ? 8.26529   12.68125  -21.61892 0.125 17.64912 ? 409  SER A O   1 
ATOM   3485 C CB  A SER A 1 328 ? 8.29757   12.08698  -19.16697 0.875 14.79674 ? 409  SER A CB  1 
ATOM   3486 C CB  B SER A 1 328 ? 8.00874   12.52806  -18.74142 0.125 17.59616 ? 409  SER A CB  1 
ATOM   3487 O OG  A SER A 1 328 ? 9.43928   12.84684  -18.82714 0.875 16.56852 ? 409  SER A OG  1 
ATOM   3488 O OG  B SER A 1 328 ? 7.49058   12.15650  -17.47947 0.125 17.88042 ? 409  SER A OG  1 
ATOM   3489 N N   A LEU A 1 329 ? 10.24853  10.62175  -21.89984 0.875 12.33740 ? 410  LEU A N   1 
ATOM   3490 N N   B LEU A 1 329 ? 9.74810   10.98639  -21.45849 0.125 15.61819 ? 410  LEU A N   1 
ATOM   3491 C CA  A LEU A 1 329 ? 10.82702  10.93584  -23.20026 0.875 13.59606 ? 410  LEU A CA  1 
ATOM   3492 C CA  B LEU A 1 329 ? 10.41437  11.26646  -22.71315 0.125 15.61652 ? 410  LEU A CA  1 
ATOM   3493 C C   A LEU A 1 329 ? 9.82015   10.70986  -24.32592 0.875 13.86228 ? 410  LEU A C   1 
ATOM   3494 C C   B LEU A 1 329 ? 9.49515   10.89218  -23.87562 0.125 16.21337 ? 410  LEU A C   1 
ATOM   3495 O O   A LEU A 1 329 ? 8.84239   9.97544   -24.15924 0.875 14.79647 ? 410  LEU A O   1 
ATOM   3496 O O   B LEU A 1 329 ? 8.52338   10.15264  -23.69367 0.125 15.30697 ? 410  LEU A O   1 
ATOM   3497 C CB  A LEU A 1 329 ? 12.03090  10.03975  -23.45134 0.875 12.59646 ? 410  LEU A CB  1 
ATOM   3498 C CB  B LEU A 1 329 ? 11.69213  10.43480  -22.78577 0.125 15.81516 ? 410  LEU A CB  1 
ATOM   3499 C CG  A LEU A 1 329 ? 13.27354  10.40515  -22.65443 0.875 13.18487 ? 410  LEU A CG  1 
ATOM   3500 C CG  B LEU A 1 329 ? 13.00861  11.07575  -22.32969 0.125 15.81114 ? 410  LEU A CG  1 
ATOM   3501 C CD1 A LEU A 1 329 ? 14.34010  9.35284   -22.87372 0.875 14.96960 ? 410  LEU A CD1 1 
ATOM   3502 C CD1 B LEU A 1 329 ? 14.13710  10.05762  -22.39125 0.125 15.55354 ? 410  LEU A CD1 1 
ATOM   3503 C CD2 A LEU A 1 329 ? 13.78547  11.78985  -23.03639 0.875 14.87059 ? 410  LEU A CD2 1 
ATOM   3504 C CD2 B LEU A 1 329 ? 13.36722  12.31364  -23.13469 0.125 15.67968 ? 410  LEU A CD2 1 
ATOM   3505 N N   A PRO A 1 330 ? 10.05682  11.32360  -25.49433 0.875 17.51877 ? 411  PRO A N   1 
ATOM   3506 N N   B PRO A 1 330 ? 9.77795   11.40536  -25.08827 0.125 18.04989 ? 411  PRO A N   1 
ATOM   3507 C CA  A PRO A 1 330 ? 9.11652   11.16582  -26.61842 0.875 15.88681 ? 411  PRO A CA  1 
ATOM   3508 C CA  B PRO A 1 330 ? 8.94622   11.07262  -26.25531 0.125 18.43119 ? 411  PRO A CA  1 
ATOM   3509 C C   A PRO A 1 330 ? 8.87449   9.72730   -27.03982 0.875 15.11403 ? 411  PRO A C   1 
ATOM   3510 C C   B PRO A 1 330 ? 8.72585   9.58565   -26.50727 0.125 17.98629 ? 411  PRO A C   1 
ATOM   3511 O O   A PRO A 1 330 ? 7.82633   9.44052   -27.62861 0.875 17.37869 ? 411  PRO A O   1 
ATOM   3512 O O   B PRO A 1 330 ? 7.57935   9.12815   -26.46522 0.125 18.04412 ? 411  PRO A O   1 
ATOM   3513 C CB  A PRO A 1 330 ? 9.77276   11.97712  -27.74473 0.875 18.98668 ? 411  PRO A CB  1 
ATOM   3514 C CB  B PRO A 1 330 ? 9.71061   11.72951  -27.40978 0.125 20.01126 ? 411  PRO A CB  1 
ATOM   3515 C CG  A PRO A 1 330 ? 10.59868  12.98754  -27.03354 0.875 20.04295 ? 411  PRO A CG  1 
ATOM   3516 C CG  B PRO A 1 330 ? 10.27983  12.94880  -26.78134 0.125 19.57829 ? 411  PRO A CG  1 
ATOM   3517 C CD  A PRO A 1 330 ? 11.12671  12.28736  -25.81654 0.875 16.71132 ? 411  PRO A CD  1 
ATOM   3518 C CD  B PRO A 1 330 ? 10.70512  12.51054  -25.39491 0.125 18.43243 ? 411  PRO A CD  1 
ATOM   3519 N N   . ASP A 1 331 ? 9.79818   8.81183   -26.76734 1.000 15.27403 ? 412  ASP A N   1 
ATOM   3520 C CA  . ASP A 1 331 ? 9.60000   7.40183   -27.11836 1.000 14.42280 ? 412  ASP A CA  1 
ATOM   3521 C C   . ASP A 1 331 ? 9.07182   6.55350   -25.96543 1.000 12.95984 ? 412  ASP A C   1 
ATOM   3522 O O   . ASP A 1 331 ? 8.93657   5.33247   -26.12372 1.000 13.93841 ? 412  ASP A O   1 
ATOM   3523 C CB  . ASP A 1 331 ? 10.83360  6.77967   -27.77975 1.000 15.02809 ? 412  ASP A CB  1 
ATOM   3524 C CG  . ASP A 1 331 ? 12.09392  6.95632   -26.97111 1.000 13.56565 ? 412  ASP A CG  1 
ATOM   3525 O OD1 . ASP A 1 331 ? 12.03054  7.50551   -25.85103 1.000 16.82812 ? 412  ASP A OD1 1 
ATOM   3526 O OD2 . ASP A 1 331 ? 13.14971  6.52827   -27.47873 1.000 13.19853 ? 412  ASP A OD2 1 
ATOM   3527 N N   . ALA A 1 332 ? 8.73098   7.16388   -24.83465 1.000 13.18903 ? 413  ALA A N   1 
ATOM   3528 C CA  . ALA A 1 332 ? 8.15058   6.46269   -23.70036 1.000 12.25107 ? 413  ALA A CA  1 
ATOM   3529 C C   . ALA A 1 332 ? 6.63046   6.57319   -23.74730 1.000 12.75230 ? 413  ALA A C   1 
ATOM   3530 O O   . ALA A 1 332 ? 6.08348   7.65704   -23.98613 1.000 14.24049 ? 413  ALA A O   1 
ATOM   3531 C CB  . ALA A 1 332 ? 8.67781   7.04791   -22.39163 1.000 14.14578 ? 413  ALA A CB  1 
ATOM   3532 N N   . ALA A 1 333 ? 5.95184   5.45242   -23.51746 1.000 12.15569 ? 414  ALA A N   1 
ATOM   3533 C CA  . ALA A 1 333 ? 4.49549   5.45378   -23.47479 1.000 12.44569 ? 414  ALA A CA  1 
ATOM   3534 C C   . ALA A 1 333 ? 4.02269   6.25393   -22.26803 1.000 13.08417 ? 414  ALA A C   1 
ATOM   3535 O O   . ALA A 1 333 ? 4.49828   6.04949   -21.14861 1.000 14.58299 ? 414  ALA A O   1 
ATOM   3536 C CB  . ALA A 1 333 ? 3.98575   4.01803   -23.37619 1.000 13.73998 ? 414  ALA A CB  1 
ATOM   3537 N N   . GLN A 1 334 ? 3.09479   7.18045   -22.49214 1.000 13.21747 ? 415  GLN A N   1 
ATOM   3538 C CA  A GLN A 1 334 ? 2.59644   8.07220   -21.44340 0.645 14.05737 ? 415  GLN A CA  1 
ATOM   3539 C CA  B GLN A 1 334 ? 2.57880   7.98737   -21.40846 0.355 13.95774 ? 415  GLN A CA  1 
ATOM   3540 C C   . GLN A 1 334 ? 1.10878   8.29612   -21.64842 1.000 14.82110 ? 415  GLN A C   1 
ATOM   3541 O O   . GLN A 1 334 ? 0.64912   8.32304   -22.79525 1.000 16.68263 ? 415  GLN A O   1 
ATOM   3542 C CB  A GLN A 1 334 ? 3.24903   9.46591   -21.48085 0.645 18.96675 ? 415  GLN A CB  1 
ATOM   3543 C CB  B GLN A 1 334 ? 3.40460   9.26530   -21.19149 0.355 16.64114 ? 415  GLN A CB  1 
ATOM   3544 C CG  A GLN A 1 334 ? 4.74864   9.52184   -21.54226 0.645 18.87368 ? 415  GLN A CG  1 
ATOM   3545 C CG  B GLN A 1 334 ? 3.79292   10.01819  -22.43987 0.355 15.44959 ? 415  GLN A CG  1 
ATOM   3546 C CD  A GLN A 1 334 ? 5.25659   10.75069  -22.28521 0.645 17.89896 ? 415  GLN A CD  1 
ATOM   3547 C CD  B GLN A 1 334 ? 4.48279   11.32287  -22.09733 0.355 20.81648 ? 415  GLN A CD  1 
ATOM   3548 O OE1 A GLN A 1 334 ? 6.21804   10.65279  -23.04117 0.645 16.24255 ? 415  GLN A OE1 1 
ATOM   3549 O OE1 B GLN A 1 334 ? 4.96503   11.50301  -20.97935 0.355 19.67693 ? 415  GLN A OE1 1 
ATOM   3550 N NE2 A GLN A 1 334 ? 4.61169   11.90935  -22.07812 0.645 14.19858 ? 415  GLN A NE2 1 
ATOM   3551 N NE2 B GLN A 1 334 ? 4.52786   12.24156  -23.05076 0.355 18.98381 ? 415  GLN A NE2 1 
ATOM   3552 N N   . PRO A 1 335 ? 0.33544   8.50320   -20.56985 1.000 14.98452 ? 416  PRO A N   1 
ATOM   3553 C CA  . PRO A 1 335 ? 0.78530   8.46508   -19.17139 1.000 14.52950 ? 416  PRO A CA  1 
ATOM   3554 C C   . PRO A 1 335 ? 1.08603   7.04404   -18.69567 1.000 13.77589 ? 416  PRO A C   1 
ATOM   3555 O O   . PRO A 1 335 ? 0.42328   6.09275   -19.11599 1.000 14.45942 ? 416  PRO A O   1 
ATOM   3556 C CB  . PRO A 1 335 ? -0.40617  9.03622   -18.40641 1.000 16.43362 ? 416  PRO A CB  1 
ATOM   3557 C CG  . PRO A 1 335 ? -1.57539  8.74093   -19.26766 1.000 17.39597 ? 416  PRO A CG  1 
ATOM   3558 C CD  . PRO A 1 335 ? -1.08160  8.88230   -20.67779 1.000 15.28881 ? 416  PRO A CD  1 
ATOM   3559 N N   . ALA A 1 336 ? 2.11013   6.91716   -17.85472 1.000 13.87690 ? 417  ALA A N   1 
ATOM   3560 C CA  . ALA A 1 336 ? 2.53596   5.64265   -17.31575 1.000 13.22137 ? 417  ALA A CA  1 
ATOM   3561 C C   . ALA A 1 336 ? 2.45230   5.66427   -15.79548 1.000 13.80760 ? 417  ALA A C   1 
ATOM   3562 O O   . ALA A 1 336 ? 2.79587   6.67654   -15.16792 1.000 15.39417 ? 417  ALA A O   1 
ATOM   3563 C CB  . ALA A 1 336 ? 3.98334   5.32372   -17.71991 1.000 13.42041 ? 417  ALA A CB  1 
ATOM   3564 N N   . PRO A 1 337 ? 2.02913   4.56834   -15.17742 1.000 15.79461 ? 418  PRO A N   1 
ATOM   3565 C CA  . PRO A 1 337 ? 1.88308   4.52511   -13.71952 1.000 15.71369 ? 418  PRO A CA  1 
ATOM   3566 C C   . PRO A 1 337 ? 3.21566   4.19120   -13.05087 1.000 14.28067 ? 418  PRO A C   1 
ATOM   3567 O O   . PRO A 1 337 ? 4.24233   3.99000   -13.70327 1.000 14.70715 ? 418  PRO A O   1 
ATOM   3568 C CB  . PRO A 1 337 ? 0.87036   3.39848   -13.52896 1.000 15.04633 ? 418  PRO A CB  1 
ATOM   3569 C CG  . PRO A 1 337 ? 1.20183   2.45222   -14.63494 1.000 15.24887 ? 418  PRO A CG  1 
ATOM   3570 C CD  . PRO A 1 337 ? 1.58507   3.31469   -15.80991 1.000 14.44379 ? 418  PRO A CD  1 
ATOM   3571 N N   . GLU A 1 338 ? 3.17978   4.12628   -11.72076 1.000 16.65610 ? 419  GLU A N   1 
ATOM   3572 C CA  . GLU A 1 338 ? 4.39045   3.92013   -10.93893 1.000 16.40083 ? 419  GLU A CA  1 
ATOM   3573 C C   . GLU A 1 338 ? 5.02511   2.56734   -11.24791 1.000 15.44071 ? 419  GLU A C   1 
ATOM   3574 O O   . GLU A 1 338 ? 4.34947   1.60682   -11.62785 1.000 15.36110 ? 419  GLU A O   1 
ATOM   3575 C CB  . GLU A 1 338 ? 4.06532   3.99979   -9.44730  1.000 17.36616 ? 419  GLU A CB  1 
ATOM   3576 C CG  . GLU A 1 338 ? 3.71161   5.39647   -8.94614  1.000 20.82519 ? 419  GLU A CG  1 
ATOM   3577 C CD  . GLU A 1 338 ? 4.91939   6.30519   -8.78924  1.000 19.79492 ? 419  GLU A CD  1 
ATOM   3578 O OE1 . GLU A 1 338 ? 6.05486   5.78578   -8.71042  1.000 22.70539 ? 419  GLU A OE1 1 
ATOM   3579 O OE2 . GLU A 1 338 ? 4.73095   7.53838   -8.72741  1.000 23.49761 ? 419  GLU A OE2 1 
ATOM   3580 N N   . ALA A 1 339 ? 6.34653   2.50375   -11.07961 1.000 17.07055 ? 420  ALA A N   1 
ATOM   3581 C CA  . ALA A 1 339 ? 7.08831   1.27666   -11.33443 1.000 16.35579 ? 420  ALA A CA  1 
ATOM   3582 C C   . ALA A 1 339 ? 6.51027   0.12545   -10.52626 1.000 18.67174 ? 420  ALA A C   1 
ATOM   3583 O O   . ALA A 1 339 ? 6.19985   0.27448   -9.34118  1.000 18.96105 ? 420  ALA A O   1 
ATOM   3584 C CB  . ALA A 1 339 ? 8.55938   1.48389   -10.97046 1.000 19.24344 ? 420  ALA A CB  1 
ATOM   3585 N N   . GLY A 1 340 ? 6.35640   -1.02367  -11.18112 1.000 17.38883 ? 421  GLY A N   1 
ATOM   3586 C CA  . GLY A 1 340 ? 5.80927   -2.20330  -10.55884 1.000 19.53331 ? 421  GLY A CA  1 
ATOM   3587 C C   . GLY A 1 340 ? 4.31172   -2.35832  -10.70050 1.000 20.87916 ? 421  GLY A C   1 
ATOM   3588 O O   . GLY A 1 340 ? 3.80821   -3.48210  -10.61173 1.000 26.97091 ? 421  GLY A O   1 
ATOM   3589 N N   . THR A 1 341 ? 3.58214   -1.27153  -10.91253 1.000 18.23734 ? 422  THR A N   1 
ATOM   3590 C CA  . THR A 1 341 ? 2.14533   -1.38102  -11.08092 1.000 17.96802 ? 422  THR A CA  1 
ATOM   3591 C C   . THR A 1 341 ? 1.80787   -1.76964  -12.51554 1.000 14.43866 ? 422  THR A C   1 
ATOM   3592 O O   . THR A 1 341 ? 2.56238   -1.50009  -13.45809 1.000 17.78352 ? 422  THR A O   1 
ATOM   3593 C CB  . THR A 1 341 ? 1.44961   -0.07521  -10.70014 1.000 19.96997 ? 422  THR A CB  1 
ATOM   3594 O OG1 . THR A 1 341 ? 1.71625   0.91674   -11.69585 1.000 21.81551 ? 422  THR A OG1 1 
ATOM   3595 C CG2 . THR A 1 341 ? 1.94313   0.42068   -9.34703  1.000 21.94396 ? 422  THR A CG2 1 
ATOM   3596 N N   . TRP A 1 342 ? 0.66285   -2.42392  -12.66849 1.000 16.93067 ? 423  TRP A N   1 
ATOM   3597 C CA  . TRP A 1 342 ? 0.25102   -2.90907  -13.97240 1.000 14.32857 ? 423  TRP A CA  1 
ATOM   3598 C C   . TRP A 1 342 ? -0.05999  -1.74170  -14.90277 1.000 12.70279 ? 423  TRP A C   1 
ATOM   3599 O O   . TRP A 1 342 ? -0.66592  -0.74402  -14.49923 1.000 15.36870 ? 423  TRP A O   1 
ATOM   3600 C CB  . TRP A 1 342 ? -0.97275  -3.80748  -13.82403 1.000 15.31906 ? 423  TRP A CB  1 
ATOM   3601 C CG  . TRP A 1 342 ? -1.28278  -4.55472  -15.06243 1.000 13.94673 ? 423  TRP A CG  1 
ATOM   3602 C CD1 . TRP A 1 342 ? -2.32670  -4.33790  -15.90416 1.000 14.83892 ? 423  TRP A CD1 1 
ATOM   3603 C CD2 . TRP A 1 342 ? -0.53636  -5.64501  -15.61584 1.000 13.39780 ? 423  TRP A CD2 1 
ATOM   3604 N NE1 . TRP A 1 342 ? -2.28120  -5.22114  -16.95200 1.000 12.85172 ? 423  TRP A NE1 1 
ATOM   3605 C CE2 . TRP A 1 342 ? -1.19131  -6.03847  -16.79593 1.000 12.68598 ? 423  TRP A CE2 1 
ATOM   3606 C CE3 . TRP A 1 342 ? 0.62362   -6.32537  -15.22712 1.000 13.07155 ? 423  TRP A CE3 1 
ATOM   3607 C CZ2 . TRP A 1 342 ? -0.72892  -7.08372  -17.59255 1.000 11.83557 ? 423  TRP A CZ2 1 
ATOM   3608 C CZ3 . TRP A 1 342 ? 1.08283   -7.36258  -16.01877 1.000 13.37393 ? 423  TRP A CZ3 1 
ATOM   3609 C CH2 . TRP A 1 342 ? 0.40695   -7.73353  -17.18735 1.000 12.79593 ? 423  TRP A CH2 1 
ATOM   3610 N N   . PHE A 1 343 ? 0.36277   -1.87635  -16.15775 1.000 13.11277 ? 424  PHE A N   1 
ATOM   3611 C CA  . PHE A 1 343 ? 0.23073   -0.84749  -17.18988 1.000 12.41287 ? 424  PHE A CA  1 
ATOM   3612 C C   . PHE A 1 343 ? -0.58819  -1.47853  -18.31324 1.000 11.39583 ? 424  PHE A C   1 
ATOM   3613 O O   . PHE A 1 343 ? -0.03672  -2.00803  -19.28039 1.000 11.60115 ? 424  PHE A O   1 
ATOM   3614 C CB  . PHE A 1 343 ? 1.64242   -0.43275  -17.64877 1.000 12.24100 ? 424  PHE A CB  1 
ATOM   3615 C CG  . PHE A 1 343 ? 1.70253   0.81489   -18.50447 1.000 12.17655 ? 424  PHE A CG  1 
ATOM   3616 C CD1 . PHE A 1 343 ? 0.56035   1.46651   -18.94574 1.000 13.38817 ? 424  PHE A CD1 1 
ATOM   3617 C CD2 . PHE A 1 343 ? 2.93894   1.32834   -18.87152 1.000 12.20119 ? 424  PHE A CD2 1 
ATOM   3618 C CE1 . PHE A 1 343 ? 0.65862   2.60841   -19.73561 1.000 12.53817 ? 424  PHE A CE1 1 
ATOM   3619 C CE2 . PHE A 1 343 ? 3.04105   2.46031   -19.65073 1.000 12.54870 ? 424  PHE A CE2 1 
ATOM   3620 C CZ  . PHE A 1 343 ? 1.90171   3.10142   -20.08940 1.000 12.61211 ? 424  PHE A CZ  1 
ATOM   3621 N N   . GLN A 1 344 ? -1.91579  -1.39619  -18.18108 1.000 12.02345 ? 425  GLN A N   1 
ATOM   3622 C CA  . GLN A 1 344 ? -2.80942  -2.18725  -19.02293 1.000 11.92000 ? 425  GLN A CA  1 
ATOM   3623 C C   . GLN A 1 344 ? -2.65290  -1.85676  -20.50541 1.000 11.55784 ? 425  GLN A C   1 
ATOM   3624 O O   . GLN A 1 344 ? -2.61242  -2.75963  -21.34616 1.000 11.72814 ? 425  GLN A O   1 
ATOM   3625 C CB  . GLN A 1 344 ? -4.25202  -1.99760  -18.55498 1.000 13.00336 ? 425  GLN A CB  1 
ATOM   3626 C CG  . GLN A 1 344 ? -5.28967  -2.67895  -19.42740 1.000 13.01009 ? 425  GLN A CG  1 
ATOM   3627 C CD  . GLN A 1 344 ? -5.26619  -4.19385  -19.30439 1.000 13.25297 ? 425  GLN A CD  1 
ATOM   3628 O OE1 . GLN A 1 344 ? -4.71380  -4.75133  -18.35238 1.000 14.50318 ? 425  GLN A OE1 1 
ATOM   3629 N NE2 . GLN A 1 344 ? -5.87660  -4.86775  -20.26994 1.000 13.99014 ? 425  GLN A NE2 1 
ATOM   3630 N N   . ALA A 1 345 ? -2.57850  -0.57246  -20.85307 1.000 11.76637 ? 426  ALA A N   1 
ATOM   3631 C CA  . ALA A 1 345 ? -2.48274  -0.21755  -22.26630 1.000 12.25568 ? 426  ALA A CA  1 
ATOM   3632 C C   . ALA A 1 345 ? -1.18703  -0.72801  -22.87856 1.000 11.88342 ? 426  ALA A C   1 
ATOM   3633 O O   . ALA A 1 345 ? -1.15599  -1.12842  -24.04948 1.000 12.58204 ? 426  ALA A O   1 
ATOM   3634 C CB  . ALA A 1 345 ? -2.59853  1.29373   -22.43568 1.000 13.66362 ? 426  ALA A CB  1 
ATOM   3635 N N   . TYR A 1 346 ? -0.10518  -0.70281  -22.09871 1.000 10.50267 ? 427  TYR A N   1 
ATOM   3636 C CA  . TYR A 1 346 ? 1.17929   -1.20080  -22.56703 1.000 10.54029 ? 427  TYR A CA  1 
ATOM   3637 C C   . TYR A 1 346 ? 1.12124   -2.69788  -22.81341 1.000 10.01324 ? 427  TYR A C   1 
ATOM   3638 O O   . TYR A 1 346 ? 1.63111   -3.18830  -23.82696 1.000 10.32357 ? 427  TYR A O   1 
ATOM   3639 C CB  . TYR A 1 346 ? 2.26118   -0.85913  -21.54265 1.000 10.80244 ? 427  TYR A CB  1 
ATOM   3640 C CG  . TYR A 1 346 ? 3.65542   -0.90362  -22.10848 1.000 10.07548 ? 427  TYR A CG  1 
ATOM   3641 C CD1 . TYR A 1 346 ? 4.20667   0.20469   -22.72502 1.000 9.86081  ? 427  TYR A CD1 1 
ATOM   3642 C CD2 . TYR A 1 346 ? 4.42103   -2.06071  -22.03622 1.000 10.17812 ? 427  TYR A CD2 1 
ATOM   3643 C CE1 . TYR A 1 346 ? 5.47935   0.16985   -23.25134 1.000 10.18688 ? 427  TYR A CE1 1 
ATOM   3644 C CE2 . TYR A 1 346 ? 5.69825   -2.10428  -22.56192 1.000 10.23240 ? 427  TYR A CE2 1 
ATOM   3645 C CZ  . TYR A 1 346 ? 6.22546   -0.98852  -23.16821 1.000 9.12287  ? 427  TYR A CZ  1 
ATOM   3646 O OH  . TYR A 1 346 ? 7.50041   -1.05683  -23.67976 1.000 10.07613 ? 427  TYR A OH  1 
ATOM   3647 N N   . PHE A 1 347 ? 0.48768   -3.42751  -21.89499 1.000 10.55700 ? 428  PHE A N   1 
ATOM   3648 C CA  . PHE A 1 347 ? 0.29013   -4.85736  -22.07654 1.000 10.50534 ? 428  PHE A CA  1 
ATOM   3649 C C   . PHE A 1 347 ? -0.52335  -5.14494  -23.32867 1.000 9.58286  ? 428  PHE A C   1 
ATOM   3650 O O   . PHE A 1 347 ? -0.17502  -6.03259  -24.11225 1.000 10.29677 ? 428  PHE A O   1 
ATOM   3651 C CB  . PHE A 1 347 ? -0.41166  -5.44825  -20.85755 1.000 10.81906 ? 428  PHE A CB  1 
ATOM   3652 C CG  . PHE A 1 347 ? -0.73860  -6.90356  -21.00682 1.000 10.21454 ? 428  PHE A CG  1 
ATOM   3653 C CD1 . PHE A 1 347 ? 0.25359   -7.86786  -20.88745 1.000 11.16256 ? 428  PHE A CD1 1 
ATOM   3654 C CD2 . PHE A 1 347 ? -2.03447  -7.31518  -21.27627 1.000 11.10171 ? 428  PHE A CD2 1 
ATOM   3655 C CE1 . PHE A 1 347 ? -0.04840  -9.21673  -21.02815 1.000 12.10582 ? 428  PHE A CE1 1 
ATOM   3656 C CE2 . PHE A 1 347 ? -2.34034  -8.65707  -21.41596 1.000 11.73480 ? 428  PHE A CE2 1 
ATOM   3657 C CZ  . PHE A 1 347 ? -1.34981  -9.60687  -21.28908 1.000 11.67407 ? 428  PHE A CZ  1 
ATOM   3658 N N   . GLN A 1 348 ? -1.63122  -4.43194  -23.52223 1.000 10.58967 ? 429  GLN A N   1 
ATOM   3659 C CA  . GLN A 1 348 ? -2.44580  -4.71406  -24.69652 1.000 11.13342 ? 429  GLN A CA  1 
ATOM   3660 C C   . GLN A 1 348 ? -1.65324  -4.51398  -25.98607 1.000 11.05600 ? 429  GLN A C   1 
ATOM   3661 O O   . GLN A 1 348 ? -1.79197  -5.29354  -26.92916 1.000 11.33841 ? 429  GLN A O   1 
ATOM   3662 C CB  . GLN A 1 348 ? -3.73357  -3.89446  -24.67944 1.000 11.53602 ? 429  GLN A CB  1 
ATOM   3663 C CG  . GLN A 1 348 ? -4.60033  -4.13844  -25.89607 1.000 12.30855 ? 429  GLN A CG  1 
ATOM   3664 C CD  . GLN A 1 348 ? -5.96433  -3.48603  -25.82042 1.000 12.19061 ? 429  GLN A CD  1 
ATOM   3665 O OE1 . GLN A 1 348 ? -6.64278  -3.51372  -24.79401 1.000 15.13994 ? 429  GLN A OE1 1 
ATOM   3666 N NE2 . GLN A 1 348 ? -6.35898  -2.85710  -26.91685 1.000 15.74932 ? 429  GLN A NE2 1 
ATOM   3667 N N   . THR A 1 349 ? -0.78791  -3.50040  -26.03570 1.000 10.92568 ? 430  THR A N   1 
ATOM   3668 C CA  . THR A 1 349 ? 0.03539   -3.31594  -27.22691 1.000 10.86937 ? 430  THR A CA  1 
ATOM   3669 C C   . THR A 1 349 ? 1.11417   -4.39208  -27.33974 1.000 9.88657  ? 430  THR A C   1 
ATOM   3670 O O   . THR A 1 349 ? 1.40347   -4.86510  -28.44291 1.000 10.59324 ? 430  THR A O   1 
ATOM   3671 C CB  . THR A 1 349 ? 0.60207   -1.89932  -27.26973 1.000 11.68190 ? 430  THR A CB  1 
ATOM   3672 O OG1 . THR A 1 349 ? -0.49340  -0.99410  -27.43461 1.000 13.88230 ? 430  THR A OG1 1 
ATOM   3673 C CG2 . THR A 1 349 ? 1.57397   -1.73378  -28.43178 1.000 12.78619 ? 430  THR A CG2 1 
ATOM   3674 N N   . LEU A 1 350 ? 1.69660   -4.82357  -26.21635 1.000 9.17686  ? 431  LEU A N   1 
ATOM   3675 C CA  . LEU A 1 350 ? 2.63588   -5.93942  -26.27068 1.000 9.05031  ? 431  LEU A CA  1 
ATOM   3676 C C   . LEU A 1 350 ? 2.00136   -7.15243  -26.93254 1.000 9.44114  ? 431  LEU A C   1 
ATOM   3677 O O   . LEU A 1 350 ? 2.65818   -7.85549  -27.70569 1.000 9.88334  ? 431  LEU A O   1 
ATOM   3678 C CB  . LEU A 1 350 ? 3.11570   -6.31932  -24.86954 1.000 9.48965  ? 431  LEU A CB  1 
ATOM   3679 C CG  . LEU A 1 350 ? 4.19853   -5.44660  -24.24177 1.000 9.43002  ? 431  LEU A CG  1 
ATOM   3680 C CD1 . LEU A 1 350 ? 4.32221   -5.75240  -22.76416 1.000 9.92462  ? 431  LEU A CD1 1 
ATOM   3681 C CD2 . LEU A 1 350 ? 5.54847   -5.61778  -24.91960 1.000 10.35102 ? 431  LEU A CD2 1 
ATOM   3682 N N   . VAL A 1 351 ? 0.73239   -7.42702  -26.61218 1.000 9.44012  ? 432  VAL A N   1 
ATOM   3683 C CA  . VAL A 1 351 ? 0.01328   -8.54700  -27.21360 1.000 9.97713  ? 432  VAL A CA  1 
ATOM   3684 C C   . VAL A 1 351 ? -0.25679  -8.27954  -28.68899 1.000 10.39274 ? 432  VAL A C   1 
ATOM   3685 O O   . VAL A 1 351 ? 0.02485   -9.11588  -29.54785 1.000 11.26726 ? 432  VAL A O   1 
ATOM   3686 C CB  . VAL A 1 351 ? -1.29698  -8.81753  -26.45070 1.000 10.80320 ? 432  VAL A CB  1 
ATOM   3687 C CG1 . VAL A 1 351 ? -2.07199  -9.93518  -27.12252 1.000 12.68204 ? 432  VAL A CG1 1 
ATOM   3688 C CG2 . VAL A 1 351 ? -1.02623  -9.14956  -24.99144 1.000 11.32950 ? 432  VAL A CG2 1 
ATOM   3689 N N   A SER A 1 352 ? -0.81015  -7.10484  -28.99615 0.681 10.92897 ? 433  SER A N   1 
ATOM   3690 N N   B SER A 1 352 ? -0.80955  -7.10779  -29.00998 0.319 10.90913 ? 433  SER A N   1 
ATOM   3691 C CA  A SER A 1 352 ? -1.18180  -6.78507  -30.36886 0.681 10.78135 ? 433  SER A CA  1 
ATOM   3692 C CA  B SER A 1 352 ? -1.18712  -6.83881  -30.39531 0.319 10.73961 ? 433  SER A CA  1 
ATOM   3693 C C   A SER A 1 352 ? 0.02500   -6.83185  -31.29521 0.681 10.86431 ? 433  SER A C   1 
ATOM   3694 C C   B SER A 1 352 ? 0.02248   -6.79982  -31.31966 0.319 10.89678 ? 433  SER A C   1 
ATOM   3695 O O   A SER A 1 352 ? -0.07141  -7.30873  -32.43288 0.681 12.27293 ? 433  SER A O   1 
ATOM   3696 O O   B SER A 1 352 ? -0.08266  -7.16701  -32.49532 0.319 12.25487 ? 433  SER A O   1 
ATOM   3697 C CB  A SER A 1 352 ? -1.82664  -5.40162  -30.39713 0.681 12.39086 ? 433  SER A CB  1 
ATOM   3698 C CB  B SER A 1 352 ? -1.96343  -5.52652  -30.48534 0.319 13.18051 ? 433  SER A CB  1 
ATOM   3699 O OG  A SER A 1 352 ? -2.28763  -5.08338  -31.69337 0.681 15.05016 ? 433  SER A OG  1 
ATOM   3700 O OG  B SER A 1 352 ? -1.13939  -4.42037  -30.16634 0.319 14.50537 ? 433  SER A OG  1 
ATOM   3701 N N   . ALA A 1 353 ? 1.17241   -6.36394  -30.81386 1.000 10.43516 ? 434  ALA A N   1 
ATOM   3702 C CA  . ALA A 1 353 ? 2.37930   -6.24018  -31.61252 1.000 11.13304 ? 434  ALA A CA  1 
ATOM   3703 C C   . ALA A 1 353 ? 3.31974   -7.43099  -31.47687 1.000 11.78212 ? 434  ALA A C   1 
ATOM   3704 O O   . ALA A 1 353 ? 4.45625   -7.35034  -31.95152 1.000 11.88594 ? 434  ALA A O   1 
ATOM   3705 C CB  . ALA A 1 353 ? 3.11701   -4.95356  -31.24671 1.000 11.16981 ? 434  ALA A CB  1 
ATOM   3706 N N   A ALA A 1 354 ? 2.87339   -8.53055  -30.86571 0.891 10.75504 ? 435  ALA A N   1 
ATOM   3707 N N   B ALA A 1 354 ? 2.88991   -8.50842  -30.82187 0.109 10.83010 ? 435  ALA A N   1 
ATOM   3708 C CA  A ALA A 1 354 ? 3.74358   -9.68021  -30.65496 0.891 10.88995 ? 435  ALA A CA  1 
ATOM   3709 C CA  B ALA A 1 354 ? 3.77433   -9.64099  -30.57716 0.109 10.96978 ? 435  ALA A CA  1 
ATOM   3710 C C   A ALA A 1 354 ? 4.30140   -10.19152 -31.97806 0.891 9.79275  ? 435  ALA A C   1 
ATOM   3711 C C   B ALA A 1 354 ? 4.34146   -10.16420 -31.89069 0.109 10.26747 ? 435  ALA A C   1 
ATOM   3712 O O   A ALA A 1 354 ? 3.60569   -10.23176 -32.99941 0.891 11.20830 ? 435  ALA A O   1 
ATOM   3713 O O   B ALA A 1 354 ? 3.59121   -10.49399 -32.81320 0.109 12.28410 ? 435  ALA A O   1 
ATOM   3714 C CB  A ALA A 1 354 ? 2.96740   -10.79780 -29.95663 0.891 11.41868 ? 435  ALA A CB  1 
ATOM   3715 C CB  B ALA A 1 354 ? 3.01039   -10.74773 -29.85053 0.109 11.47092 ? 435  ALA A CB  1 
ATOM   3716 N N   A ASN A 1 355 ? 5.56635   -10.57512 -31.95729 0.891 9.91210  ? 436  ASN A N   1 
ATOM   3717 N N   B ASN A 1 355 ? 5.66848   -10.19983 -31.98706 0.109 11.42196 ? 436  ASN A N   1 
ATOM   3718 C CA  A ASN A 1 355 ? 6.22105   -11.11386 -33.13471 0.891 11.41259 ? 436  ASN A CA  1 
ATOM   3719 C CA  B ASN A 1 355 ? 6.36688   -10.80856 -33.11840 0.109 12.57497 ? 436  ASN A CA  1 
ATOM   3720 C C   A ASN A 1 355 ? 7.22601   -12.15223 -32.66419 0.891 10.70312 ? 436  ASN A C   1 
ATOM   3721 C C   B ASN A 1 355 ? 7.40769   -11.75837 -32.54572 0.109 12.93120 ? 436  ASN A C   1 
ATOM   3722 O O   A ASN A 1 355 ? 8.21799   -11.79882 -32.01117 0.891 11.82412 ? 436  ASN A O   1 
ATOM   3723 O O   B ASN A 1 355 ? 8.45419   -11.30451 -32.05002 0.109 7.49080  ? 436  ASN A O   1 
ATOM   3724 C CB  A ASN A 1 355 ? 6.91269   -10.00286 -33.91565 0.891 13.27876 ? 436  ASN A CB  1 
ATOM   3725 C CB  B ASN A 1 355 ? 7.02722   -9.76605  -34.00890 0.109 13.41379 ? 436  ASN A CB  1 
ATOM   3726 C CG  A ASN A 1 355 ? 7.76537   -10.53209 -35.03279 0.891 14.15321 ? 436  ASN A CG  1 
ATOM   3727 C CG  B ASN A 1 355 ? 6.15008   -8.56368  -34.24032 0.109 13.64181 ? 436  ASN A CG  1 
ATOM   3728 O OD1 A ASN A 1 355 ? 7.43639   -11.53878 -35.65782 0.891 16.10500 ? 436  ASN A OD1 1 
ATOM   3729 O OD1 B ASN A 1 355 ? 4.95799   -8.69268  -34.52029 0.109 14.77675 ? 436  ASN A OD1 1 
ATOM   3730 N ND2 A ASN A 1 355 ? 8.89436   -9.87692  -35.26884 0.891 15.87475 ? 436  ASN A ND2 1 
ATOM   3731 N ND2 B ASN A 1 355 ? 6.73208   -7.37779  -34.12205 0.109 13.84285 ? 436  ASN A ND2 1 
ATOM   3732 N N   A PRO A 1 356 ? 7.00042   -13.44275 -32.94426 0.891 13.47078 ? 437  PRO A N   1 
ATOM   3733 N N   B PRO A 1 356 ? 7.17220   -13.08028 -32.60097 0.109 12.64150 ? 437  PRO A N   1 
ATOM   3734 C CA  A PRO A 1 356 ? 5.86147   -13.99650 -33.69961 0.891 15.18619 ? 437  PRO A CA  1 
ATOM   3735 C CA  B PRO A 1 356 ? 6.05710   -13.75704 -33.27967 0.109 15.64865 ? 437  PRO A CA  1 
ATOM   3736 C C   A PRO A 1 356 ? 4.50079   -13.76712 -33.02752 0.891 13.95013 ? 437  PRO A C   1 
ATOM   3737 C C   B PRO A 1 356 ? 4.68534   -13.49311 -32.65915 0.109 14.81149 ? 437  PRO A C   1 
ATOM   3738 O O   A PRO A 1 356 ? 4.46837   -13.55413 -31.82035 0.891 13.26837 ? 437  PRO A O   1 
ATOM   3739 O O   B PRO A 1 356 ? 4.58839   -13.31119 -31.44342 0.109 15.50965 ? 437  PRO A O   1 
ATOM   3740 C CB  A PRO A 1 356 ? 6.18207   -15.49596 -33.75819 0.891 18.80203 ? 437  PRO A CB  1 
ATOM   3741 C CB  B PRO A 1 356 ? 6.41150   -15.24773 -33.13971 0.109 16.26928 ? 437  PRO A CB  1 
ATOM   3742 C CG  A PRO A 1 356 ? 7.65982   -15.58656 -33.52259 0.891 20.55658 ? 437  PRO A CG  1 
ATOM   3743 C CG  B PRO A 1 356 ? 7.82788   -15.28771 -32.63496 0.109 15.63923 ? 437  PRO A CG  1 
ATOM   3744 C CD  A PRO A 1 356 ? 7.97318   -14.48339 -32.56902 0.891 16.38443 ? 437  PRO A CD  1 
ATOM   3745 C CD  B PRO A 1 356 ? 8.00484   -14.03545 -31.85533 0.109 14.02179 ? 437  PRO A CD  1 
ATOM   3746 N N   A PRO A 1 357 ? 3.40528   -13.78036 -33.79554 0.891 16.24232 ? 438  PRO A N   1 
ATOM   3747 N N   B PRO A 1 357 ? 3.64323   -13.45762 -33.48802 0.109 16.67405 ? 438  PRO A N   1 
ATOM   3748 C CA  A PRO A 1 357 ? 2.09231   -13.47326 -33.20940 0.891 15.30826 ? 438  PRO A CA  1 
ATOM   3749 C CA  B PRO A 1 357 ? 2.29424   -13.22942 -32.96301 0.109 16.58762 ? 438  PRO A CA  1 
ATOM   3750 C C   A PRO A 1 357 ? 1.70622   -14.49645 -32.15352 0.891 15.45386 ? 438  PRO A C   1 
ATOM   3751 C C   B PRO A 1 357 ? 1.81809   -14.38313 -32.09818 0.109 15.84096 ? 438  PRO A C   1 
ATOM   3752 O O   A PRO A 1 357 ? 2.11581   -15.65589 -32.20722 0.891 18.83554 ? 438  PRO A O   1 
ATOM   3753 O O   B PRO A 1 357 ? 2.25339   -15.52743 -32.24238 0.109 18.73960 ? 438  PRO A O   1 
ATOM   3754 C CB  A PRO A 1 357 ? 1.14031   -13.53748 -34.41275 0.891 18.83676 ? 438  PRO A CB  1 
ATOM   3755 C CB  B PRO A 1 357 ? 1.44173   -13.08164 -34.22725 0.109 17.85897 ? 438  PRO A CB  1 
ATOM   3756 C CG  A PRO A 1 357 ? 2.02423   -13.46009 -35.62719 0.891 23.57179 ? 438  PRO A CG  1 
ATOM   3757 C CG  B PRO A 1 357 ? 2.18147   -13.85756 -35.26392 0.109 18.96346 ? 438  PRO A CG  1 
ATOM   3758 C CD  A PRO A 1 357 ? 3.31030   -14.10189 -35.23008 0.891 20.16051 ? 438  PRO A CD  1 
ATOM   3759 C CD  B PRO A 1 357 ? 3.64212   -13.67057 -34.94411 0.109 17.43556 ? 438  PRO A CD  1 
ATOM   3760 N N   . LEU A 1 358 ? 0.91151   -14.05662 -31.18437 0.879 15.63347 ? 439  LEU A N   1 
ATOM   3761 C CA  . LEU A 1 358 ? 0.42140   -14.98674 -30.18125 0.879 17.47123 ? 439  LEU A CA  1 
ATOM   3762 C C   . LEU A 1 358 ? -0.69993  -15.82930 -30.76975 0.879 24.53352 ? 439  LEU A C   1 
ATOM   3763 O O   . LEU A 1 358 ? -1.14658  -16.81992 -30.19123 0.879 28.98116 ? 439  LEU A O   1 
ATOM   3764 C CB  . LEU A 1 358 ? -0.03710  -14.21863 -28.94493 0.879 17.70499 ? 439  LEU A CB  1 
ATOM   3765 C CG  . LEU A 1 358 ? 1.14761   -13.66424 -28.15645 0.879 14.18552 ? 439  LEU A CG  1 
ATOM   3766 C CD1 . LEU A 1 358 ? 0.68345   -12.52176 -27.28916 0.879 16.76897 ? 439  LEU A CD1 1 
ATOM   3767 C CD2 . LEU A 1 358 ? 1.78272   -14.75288 -27.30001 0.879 17.15554 ? 439  LEU A CD2 1 
ATOM   3768 O OXT . LEU A 1 358 ? -1.17860  -15.52838 -31.86362 0.879 24.91851 ? 439  LEU A OXT 1 
HETATM 3769 C C1  . NAG B 2 .   ? 1.50382   12.89535  -9.64303  1.000 35.35975 ? 501  NAG A C1  1 
HETATM 3770 C C2  . NAG B 2 .   ? 0.10307   12.42645  -9.32133  1.000 37.32035 ? 501  NAG A C2  1 
HETATM 3771 C C3  . NAG B 2 .   ? -0.51774  13.27054  -8.26816  1.000 38.92028 ? 501  NAG A C3  1 
HETATM 3772 C C4  . NAG B 2 .   ? 0.29386   13.17387  -7.00706  1.000 37.02239 ? 501  NAG A C4  1 
HETATM 3773 C C5  . NAG B 2 .   ? 1.71103   13.68391  -7.25788  1.000 40.30770 ? 501  NAG A C5  1 
HETATM 3774 C C6  . NAG B 2 .   ? 2.53973   13.47042  -6.00951  1.000 40.96012 ? 501  NAG A C6  1 
HETATM 3775 C C7  . NAG B 2 .   ? -0.90765  11.21742  -11.36799 1.000 42.25648 ? 501  NAG A C7  1 
HETATM 3776 C C8  . NAG B 2 .   ? -1.74151  11.23888  -12.63953 1.000 36.99868 ? 501  NAG A C8  1 
HETATM 3777 N N2  . NAG B 2 .   ? -0.72916  12.45473  -10.58289 1.000 42.11479 ? 501  NAG A N2  1 
HETATM 3778 O O3  . NAG B 2 .   ? -1.86391  12.81943  -8.00807  1.000 43.03488 ? 501  NAG A O3  1 
HETATM 3779 O O4  . NAG B 2 .   ? -0.32164  13.94705  -5.97507  1.000 46.42619 ? 501  NAG A O4  1 
HETATM 3780 O O5  . NAG B 2 .   ? 2.36178   13.00300  -8.39014  1.000 40.63816 ? 501  NAG A O5  1 
HETATM 3781 O O6  . NAG B 2 .   ? 3.43047   12.40258  -6.20588  1.000 37.57736 ? 501  NAG A O6  1 
HETATM 3782 O O7  . NAG B 2 .   ? -0.40378  10.21058  -11.00986 1.000 38.88773 ? 501  NAG A O7  1 
HETATM 3783 O O   . HOH C 3 .   ? 35.32147  6.48841   -10.36430 1.000 25.56899 ? 601  HOH A O   1 
HETATM 3784 O O   . HOH C 3 .   ? -8.87977  -13.83290 -18.04629 1.000 20.55833 ? 602  HOH A O   1 
HETATM 3785 O O   . HOH C 3 .   ? 3.80573   -6.32963  -10.51534 1.000 26.65061 ? 603  HOH A O   1 
HETATM 3786 O O   . HOH C 3 .   ? 9.23533   -34.66933 -9.53011  1.000 17.83894 ? 604  HOH A O   1 
HETATM 3787 O O   . HOH C 3 .   ? 5.92840   -38.65429 -9.41242  1.000 27.60806 ? 605  HOH A O   1 
HETATM 3788 O O   A HOH C 3 .   ? 8.62932   14.45371  -22.69775 0.424 9.59459  ? 606  HOH A O   1 
HETATM 3789 O O   B HOH C 3 .   ? 11.05957  14.39496  -22.46142 0.576 12.58813 ? 606  HOH A O   1 
HETATM 3790 O O   . HOH C 3 .   ? 5.30427   9.17323   -25.98897 1.000 21.44920 ? 607  HOH A O   1 
HETATM 3791 O O   A HOH C 3 .   ? 24.15928  -27.67223 -24.33597 0.737 8.88909  ? 608  HOH A O   1 
HETATM 3792 O O   B HOH C 3 .   ? 24.45145  -26.62254 -24.10232 0.263 7.20574  ? 608  HOH A O   1 
HETATM 3793 O O   . HOH C 3 .   ? 40.337    -13.573   -4.990    1.000 14.83323 ? 609  HOH A O   1 
HETATM 3794 O O   . HOH C 3 .   ? -2.54043  -17.69835 -10.58934 1.000 26.82133 ? 610  HOH A O   1 
HETATM 3795 O O   A HOH C 3 .   ? 16.82903  -26.62293 -5.38988  0.580 12.15893 ? 611  HOH A O   1 
HETATM 3796 O O   B HOH C 3 .   ? 14.92708  -25.42338 -4.26643  0.420 11.53057 ? 611  HOH A O   1 
HETATM 3797 O O   . HOH C 3 .   ? 6.256     -36.285   -1.066    1.000 26.89659 ? 612  HOH A O   1 
HETATM 3798 O O   . HOH C 3 .   ? 11.94597  -30.83878 -2.69718  1.000 22.08341 ? 613  HOH A O   1 
HETATM 3799 O O   . HOH C 3 .   ? 24.85196  -18.15490 -33.76115 1.000 22.35603 ? 614  HOH A O   1 
HETATM 3800 O O   . HOH C 3 .   ? 7.015     -19.142   1.774     1.000 9.05786  ? 615  HOH A O   1 
HETATM 3801 O O   . HOH C 3 .   ? 4.676     -6.149    -34.444   1.000 19.14168 ? 616  HOH A O   1 
HETATM 3802 O O   . HOH C 3 .   ? 3.89991   -10.48113 -35.79876 1.000 21.43635 ? 617  HOH A O   1 
HETATM 3803 O O   . HOH C 3 .   ? 18.44635  -23.00203 6.43018   1.000 26.73147 ? 618  HOH A O   1 
HETATM 3804 O O   . HOH C 3 .   ? 10.35277  5.38396   -11.03937 1.000 27.09101 ? 619  HOH A O   1 
HETATM 3805 O O   . HOH C 3 .   ? 5.99461   -12.47473 -1.00413  1.000 13.87158 ? 620  HOH A O   1 
HETATM 3806 O O   . HOH C 3 .   ? 24.36959  -25.76459 -22.27964 1.000 15.45830 ? 621  HOH A O   1 
HETATM 3807 O O   . HOH C 3 .   ? 20.73355  -29.94444 -23.82084 1.000 11.94467 ? 622  HOH A O   1 
HETATM 3808 O O   . HOH C 3 .   ? 43.80064  -17.44016 -18.78009 1.000 27.76501 ? 623  HOH A O   1 
HETATM 3809 O O   . HOH C 3 .   ? 13.83128  -30.67085 -22.41913 1.000 25.07658 ? 624  HOH A O   1 
HETATM 3810 O O   . HOH C 3 .   ? 13.04067  -26.34899 -19.14811 1.000 15.32108 ? 625  HOH A O   1 
HETATM 3811 O O   . HOH C 3 .   ? 17.47142  10.24752  -24.93855 1.000 18.34840 ? 626  HOH A O   1 
HETATM 3812 O O   . HOH C 3 .   ? 3.552     -7.837    -36.397   1.000 29.00053 ? 627  HOH A O   1 
HETATM 3813 O O   . HOH C 3 .   ? 33.93781  8.99123   -9.97574  1.000 26.97239 ? 628  HOH A O   1 
HETATM 3814 O O   . HOH C 3 .   ? 10.95035  -36.87834 -14.06111 1.000 25.03079 ? 629  HOH A O   1 
HETATM 3815 O O   . HOH C 3 .   ? 41.573    -12.406   -7.178    1.000 20.56068 ? 630  HOH A O   1 
HETATM 3816 O O   . HOH C 3 .   ? 35.06662  -1.68595  -12.22281 1.000 22.34105 ? 631  HOH A O   1 
HETATM 3817 O O   . HOH C 3 .   ? -7.02027  -3.07527  -22.33506 1.000 19.23146 ? 632  HOH A O   1 
HETATM 3818 O O   . HOH C 3 .   ? 21.12744  -4.54078  -16.80650 1.000 10.88785 ? 633  HOH A O   1 
HETATM 3819 O O   . HOH C 3 .   ? 31.89394  -21.60251 -13.59001 1.000 10.70873 ? 634  HOH A O   1 
HETATM 3820 O O   . HOH C 3 .   ? 7.77895   -1.25728  -18.81290 1.000 20.30435 ? 635  HOH A O   1 
HETATM 3821 O O   A HOH C 3 .   ? 31.50398  -8.16276  -34.00762 0.575 15.82564 ? 636  HOH A O   1 
HETATM 3822 O O   B HOH C 3 .   ? 31.68956  -6.89096  -34.60891 0.425 17.23486 ? 636  HOH A O   1 
HETATM 3823 O O   A HOH C 3 .   ? 4.98111   -25.63018 -16.48596 0.499 15.74743 ? 637  HOH A O   1 
HETATM 3824 O O   B HOH C 3 .   ? 5.51552   -25.27340 -17.84865 0.501 19.49755 ? 637  HOH A O   1 
HETATM 3825 O O   . HOH C 3 .   ? 39.68237  -9.10534  -22.61508 1.000 20.40325 ? 638  HOH A O   1 
HETATM 3826 O O   . HOH C 3 .   ? 19.70311  5.62607   -8.25308  1.000 17.15299 ? 639  HOH A O   1 
HETATM 3827 O O   . HOH C 3 .   ? 11.39826  6.21459   -31.91933 1.000 23.16236 ? 640  HOH A O   1 
HETATM 3828 O O   . HOH C 3 .   ? 12.32684  13.65759  -20.13385 1.000 18.63313 ? 641  HOH A O   1 
HETATM 3829 O O   . HOH C 3 .   ? 17.14893  -2.94306  -15.59586 1.000 21.87745 ? 642  HOH A O   1 
HETATM 3830 O O   . HOH C 3 .   ? 26.99968  -17.95385 -31.86542 1.000 13.29384 ? 643  HOH A O   1 
HETATM 3831 O O   A HOH C 3 .   ? 26.33444  -2.96722  5.57744   0.538 14.17349 ? 644  HOH A O   1 
HETATM 3832 O O   B HOH C 3 .   ? 27.19839  -1.77267  6.20256   0.462 13.78185 ? 644  HOH A O   1 
HETATM 3833 O O   . HOH C 3 .   ? 21.14593  -30.97611 -15.80966 1.000 11.37397 ? 645  HOH A O   1 
HETATM 3834 O O   . HOH C 3 .   ? 10.94826  -11.50913 -32.66790 1.000 11.80004 ? 646  HOH A O   1 
HETATM 3835 O O   . HOH C 3 .   ? 7.95660   -4.70512  -8.00034  1.000 28.82407 ? 647  HOH A O   1 
HETATM 3836 O O   . HOH C 3 .   ? 16.57127  2.57277   0.68730   1.000 26.42408 ? 648  HOH A O   1 
HETATM 3837 O O   . HOH C 3 .   ? -13.29404 -9.36069  -24.28779 1.000 21.83425 ? 649  HOH A O   1 
HETATM 3838 O O   . HOH C 3 .   ? 12.09080  0.13575   -13.59226 1.000 24.27798 ? 650  HOH A O   1 
HETATM 3839 O O   . HOH C 3 .   ? 5.18306   -31.08016 -19.90874 1.000 24.92958 ? 651  HOH A O   1 
HETATM 3840 O O   . HOH C 3 .   ? 25.87196  6.05512   7.42628   1.000 21.25578 ? 652  HOH A O   1 
HETATM 3841 O O   . HOH C 3 .   ? 8.91435   -32.60411 -7.79457  1.000 12.67248 ? 653  HOH A O   1 
HETATM 3842 O O   . HOH C 3 .   ? 14.52217  -1.20638  -19.47794 1.000 16.29468 ? 654  HOH A O   1 
HETATM 3843 O O   A HOH C 3 .   ? 20.09992  7.45487   -32.04700 0.637 13.60050 ? 655  HOH A O   1 
HETATM 3844 O O   B HOH C 3 .   ? 17.52823  6.22063   -34.09527 0.363 14.32267 ? 655  HOH A O   1 
HETATM 3845 O O   A HOH C 3 .   ? 6.68246   -11.10181 -8.02775  0.512 10.66000 ? 656  HOH A O   1 
HETATM 3846 O O   B HOH C 3 .   ? 7.83118   -10.44282 -7.69264  0.488 15.98041 ? 656  HOH A O   1 
HETATM 3847 O O   . HOH C 3 .   ? -0.79424  1.41399   -26.45995 1.000 24.98080 ? 657  HOH A O   1 
HETATM 3848 O O   . HOH C 3 .   ? 15.89544  -12.80979 -35.56153 1.000 23.47357 ? 658  HOH A O   1 
HETATM 3849 O O   A HOH C 3 .   ? 19.71666  -30.36084 -18.06702 0.643 9.22823  ? 659  HOH A O   1 
HETATM 3850 O O   B HOH C 3 .   ? 19.54999  -30.08556 -17.40396 0.357 9.61945  ? 659  HOH A O   1 
HETATM 3851 O O   . HOH C 3 .   ? 14.38724  4.65242   -12.64420 1.000 15.82276 ? 660  HOH A O   1 
HETATM 3852 O O   . HOH C 3 .   ? -1.32469  0.60454   -12.34400 1.000 31.06764 ? 661  HOH A O   1 
HETATM 3853 O O   . HOH C 3 .   ? 9.27791   -13.29432 -36.31592 1.000 25.34708 ? 662  HOH A O   1 
HETATM 3854 O O   . HOH C 3 .   ? 41.10663  -16.64878 -14.51980 1.000 25.84114 ? 663  HOH A O   1 
HETATM 3855 O O   . HOH C 3 .   ? 6.72457   5.95134   -19.50080 1.000 14.31629 ? 664  HOH A O   1 
HETATM 3856 O O   . HOH C 3 .   ? 32.99656  -15.91662 -31.29994 1.000 17.54708 ? 665  HOH A O   1 
HETATM 3857 O O   . HOH C 3 .   ? 22.35747  -29.87309 -10.69424 1.000 10.12611 ? 666  HOH A O   1 
HETATM 3858 O O   A HOH C 3 .   ? 5.90988   -13.23076 -8.01279  0.631 12.31590 ? 667  HOH A O   1 
HETATM 3859 O O   B HOH C 3 .   ? 5.99247   -12.08965 -7.62191  0.369 11.30501 ? 667  HOH A O   1 
HETATM 3860 O O   . HOH C 3 .   ? 30.317    -10.676   2.199     1.000 10.05409 ? 668  HOH A O   1 
HETATM 3861 O O   . HOH C 3 .   ? 21.093    11.957    -15.535   1.000 23.50351 ? 669  HOH A O   1 
HETATM 3862 O O   . HOH C 3 .   ? 9.46680   14.52975  -8.79487  1.000 27.48829 ? 670  HOH A O   1 
HETATM 3863 O O   . HOH C 3 .   ? 24.36355  -14.80302 -36.42929 1.000 23.32833 ? 671  HOH A O   1 
HETATM 3864 O O   . HOH C 3 .   ? 18.56822  0.87218   -3.09972  1.000 15.46303 ? 672  HOH A O   1 
HETATM 3865 O O   . HOH C 3 .   ? 4.43002   15.47560  -15.52564 1.000 24.68634 ? 673  HOH A O   1 
HETATM 3866 O O   . HOH C 3 .   ? 19.68596  -0.63513  4.21541   1.000 12.24425 ? 674  HOH A O   1 
HETATM 3867 O O   . HOH C 3 .   ? -14.02227 -6.72975  -31.68498 1.000 24.88498 ? 675  HOH A O   1 
HETATM 3868 O O   . HOH C 3 .   ? 20.87967  -7.44653  -19.23960 1.000 9.01504  ? 676  HOH A O   1 
HETATM 3869 O O   A HOH C 3 .   ? 27.03414  -15.34645 6.35209   0.718 22.45313 ? 677  HOH A O   1 
HETATM 3870 O O   B HOH C 3 .   ? 28.89177  -15.10715 5.61706   0.282 13.81788 ? 677  HOH A O   1 
HETATM 3871 O O   . HOH C 3 .   ? 10.53643  -5.81082  1.70434   1.000 12.98322 ? 678  HOH A O   1 
HETATM 3872 O O   . HOH C 3 .   ? 6.48226   -13.90706 -10.59209 1.000 13.96377 ? 679  HOH A O   1 
HETATM 3873 O O   . HOH C 3 .   ? 35.29241  -8.23686  -7.30658  1.000 23.78349 ? 680  HOH A O   1 
HETATM 3874 O O   . HOH C 3 .   ? 30.50646  0.70542   -1.65191  1.000 12.47643 ? 681  HOH A O   1 
HETATM 3875 O O   . HOH C 3 .   ? 12.49069  11.25324  -8.34634  1.000 29.60206 ? 682  HOH A O   1 
HETATM 3876 O O   . HOH C 3 .   ? 26.21925  -16.08905 -34.90574 1.000 18.29958 ? 683  HOH A O   1 
HETATM 3877 O O   . HOH C 3 .   ? 11.87562  -15.69213 -33.38003 1.000 15.91643 ? 684  HOH A O   1 
HETATM 3878 O O   . HOH C 3 .   ? 41.977    -7.341    -15.397   1.000 24.67784 ? 685  HOH A O   1 
HETATM 3879 O O   A HOH C 3 .   ? 8.03239   -8.05388  -11.08822 0.707 14.84454 ? 686  HOH A O   1 
HETATM 3880 O O   B HOH C 3 .   ? 9.78686   -7.14476  -13.04623 0.293 14.55825 ? 686  HOH A O   1 
HETATM 3881 O O   . HOH C 3 .   ? 35.13641  -19.74450 -28.96489 1.000 25.58049 ? 687  HOH A O   1 
HETATM 3882 O O   A HOH C 3 .   ? 16.60020  14.75571  -16.61958 0.513 16.29759 ? 688  HOH A O   1 
HETATM 3883 O O   B HOH C 3 .   ? 15.91520  15.85785  -17.62147 0.487 19.40396 ? 688  HOH A O   1 
HETATM 3884 O O   . HOH C 3 .   ? 11.55854  -2.70504  -6.06626  1.000 22.07937 ? 689  HOH A O   1 
HETATM 3885 O O   . HOH C 3 .   ? 11.02095  -13.86084 4.26688   1.000 14.71730 ? 690  HOH A O   1 
HETATM 3886 O O   . HOH C 3 .   ? 17.69907  -33.78080 -11.26788 1.000 25.11459 ? 691  HOH A O   1 
HETATM 3887 O O   A HOH C 3 .   ? 24.89324  -20.00740 3.25486   0.651 15.08398 ? 692  HOH A O   1 
HETATM 3888 O O   B HOH C 3 .   ? 24.37117  -20.70391 1.42745   0.349 13.04760 ? 692  HOH A O   1 
HETATM 3889 O O   . HOH C 3 .   ? 4.420     -1.720    -32.474   1.000 12.74856 ? 693  HOH A O   1 
HETATM 3890 O O   A HOH C 3 .   ? 8.42398   4.06672   -30.10424 0.781 12.96205 ? 694  HOH A O   1 
HETATM 3891 O O   B HOH C 3 .   ? 8.69956   4.49252   -29.30208 0.219 11.02934 ? 694  HOH A O   1 
HETATM 3892 O O   . HOH C 3 .   ? 2.02611   -22.23566 -11.68284 1.000 17.23257 ? 695  HOH A O   1 
HETATM 3893 O O   . HOH C 3 .   ? 30.15631  -21.44826 -2.64462  1.000 11.90744 ? 696  HOH A O   1 
HETATM 3894 O O   . HOH C 3 .   ? 10.70723  -0.48093  -19.64204 1.000 18.24088 ? 697  HOH A O   1 
HETATM 3895 O O   . HOH C 3 .   ? 18.38794  -28.94161 -5.77630  1.000 24.77744 ? 698  HOH A O   1 
HETATM 3896 O O   . HOH C 3 .   ? 14.91849  2.81445   -33.48108 1.000 11.84434 ? 699  HOH A O   1 
HETATM 3897 O O   . HOH C 3 .   ? 32.27925  -12.36752 -6.70513  1.000 9.68807  ? 700  HOH A O   1 
HETATM 3898 O O   . HOH C 3 .   ? 30.285    -24.456   -5.897    1.000 12.88625 ? 701  HOH A O   1 
HETATM 3899 O O   . HOH C 3 .   ? 13.94837  -21.93744 -21.38678 1.000 11.43244 ? 702  HOH A O   1 
HETATM 3900 O O   A HOH C 3 .   ? 34.274    -0.359    0.926     0.638 17.35566 ? 703  HOH A O   1 
HETATM 3901 O O   B HOH C 3 .   ? 36.915    -0.273    0.994     0.362 18.38853 ? 703  HOH A O   1 
HETATM 3902 O O   . HOH C 3 .   ? 14.79452  -13.42596 -31.23552 1.000 15.01058 ? 704  HOH A O   1 
HETATM 3903 O O   . HOH C 3 .   ? 39.24134  -18.35246 -7.82697  1.000 13.76988 ? 705  HOH A O   1 
HETATM 3904 O O   . HOH C 3 .   ? 28.94785  -1.71800  2.08363   1.000 12.58233 ? 706  HOH A O   1 
HETATM 3905 O O   . HOH C 3 .   ? 20.96174  -4.50908  -9.10210  1.000 9.54735  ? 707  HOH A O   1 
HETATM 3906 O O   . HOH C 3 .   ? -9.270    -4.825    -27.719   1.000 22.12609 ? 708  HOH A O   1 
HETATM 3907 O O   . HOH C 3 .   ? 9.15775   -26.70509 4.68455   1.000 19.36559 ? 709  HOH A O   1 
HETATM 3908 O O   . HOH C 3 .   ? -1.382    -35.465   -7.641    1.000 15.88593 ? 710  HOH A O   1 
HETATM 3909 O O   . HOH C 3 .   ? -16.29277 -6.81792  -26.95506 1.000 20.73022 ? 711  HOH A O   1 
HETATM 3910 O O   . HOH C 3 .   ? 16.45048  -3.42036  -36.67015 1.000 10.79189 ? 712  HOH A O   1 
HETATM 3911 O O   . HOH C 3 .   ? 26.021    -3.340    9.719     1.000 15.31511 ? 713  HOH A O   1 
HETATM 3912 O O   . HOH C 3 .   ? 20.29624  4.46798   -20.34053 1.000 25.07762 ? 714  HOH A O   1 
HETATM 3913 O O   . HOH C 3 .   ? 26.60366  5.01818   -3.45834  1.000 14.08556 ? 715  HOH A O   1 
HETATM 3914 O O   . HOH C 3 .   ? 10.458    -30.161   1.152     1.000 20.77868 ? 716  HOH A O   1 
HETATM 3915 O O   . HOH C 3 .   ? 32.02841  -21.25682 -4.74142  1.000 16.05854 ? 717  HOH A O   1 
HETATM 3916 O O   . HOH C 3 .   ? 19.47793  -27.65160 -3.88304  1.000 26.29867 ? 718  HOH A O   1 
HETATM 3917 O O   A HOH C 3 .   ? 34.926    -23.738   -12.807   0.691 13.28617 ? 719  HOH A O   1 
HETATM 3918 O O   B HOH C 3 .   ? 37.511    -23.210   -12.868   0.309 12.92574 ? 719  HOH A O   1 
HETATM 3919 O O   . HOH C 3 .   ? 24.91976  4.14842   -31.27513 1.000 10.80330 ? 720  HOH A O   1 
HETATM 3920 O O   . HOH C 3 .   ? 13.53352  -33.57833 -9.03166  1.000 23.89561 ? 721  HOH A O   1 
HETATM 3921 O O   . HOH C 3 .   ? -0.62574  -23.62362 -18.52960 1.000 17.43436 ? 722  HOH A O   1 
HETATM 3922 O O   . HOH C 3 .   ? 2.79232   11.80980  -18.08268 1.000 27.39313 ? 723  HOH A O   1 
HETATM 3923 O O   . HOH C 3 .   ? 11.67510  -29.46144 3.25398   1.000 28.25266 ? 724  HOH A O   1 
HETATM 3924 O O   . HOH C 3 .   ? 23.13895  -10.47665 -36.74056 1.000 17.53044 ? 725  HOH A O   1 
HETATM 3925 O O   . HOH C 3 .   ? 8.82309   -5.68607  -3.91618  1.000 21.56519 ? 726  HOH A O   1 
HETATM 3926 O O   A HOH C 3 .   ? 27.75097  -8.75548  7.60452   0.654 14.11613 ? 727  HOH A O   1 
HETATM 3927 O O   B HOH C 3 .   ? 27.99887  -7.70657  5.09384   0.346 13.17902 ? 727  HOH A O   1 
HETATM 3928 O O   . HOH C 3 .   ? 5.10507   -16.73210 -16.62534 1.000 10.50551 ? 728  HOH A O   1 
HETATM 3929 O O   . HOH C 3 .   ? 20.12960  -21.76032 5.08008   1.000 24.50166 ? 729  HOH A O   1 
HETATM 3930 O O   A HOH C 3 .   ? 38.94444  -1.79571  -24.56973 0.757 10.87935 ? 730  HOH A O   1 
HETATM 3931 O O   B HOH C 3 .   ? 38.81929  -1.06630  -23.85805 0.243 11.13284 ? 730  HOH A O   1 
HETATM 3932 O O   . HOH C 3 .   ? 11.64767  -24.85758 -27.26588 1.000 24.34632 ? 731  HOH A O   1 
HETATM 3933 O O   . HOH C 3 .   ? 37.38405  -3.99553  -15.72026 1.000 17.87542 ? 732  HOH A O   1 
HETATM 3934 O O   . HOH C 3 .   ? 2.08349   -33.98614 -5.71882  1.000 15.63826 ? 733  HOH A O   1 
HETATM 3935 O O   . HOH C 3 .   ? 20.09192  -0.04082  -40.87515 1.000 21.21690 ? 734  HOH A O   1 
HETATM 3936 O O   . HOH C 3 .   ? 16.99952  -2.45020  -31.19705 1.000 10.38618 ? 735  HOH A O   1 
HETATM 3937 O O   . HOH C 3 .   ? 2.63116   8.89738   -9.82450  1.000 32.92603 ? 736  HOH A O   1 
HETATM 3938 O O   . HOH C 3 .   ? 18.48188  0.96074   -23.32674 1.000 15.81968 ? 737  HOH A O   1 
HETATM 3939 O O   . HOH C 3 .   ? 15.13458  10.15699  -26.88646 1.000 15.21389 ? 738  HOH A O   1 
HETATM 3940 O O   . HOH C 3 .   ? 36.02617  -10.56234 -29.38156 1.000 16.26302 ? 739  HOH A O   1 
HETATM 3941 O O   . HOH C 3 .   ? 31.361    -10.805   -0.309    1.000 8.54332  ? 740  HOH A O   1 
HETATM 3942 O O   . HOH C 3 .   ? -6.55393  -12.59154 -12.11441 1.000 19.14159 ? 741  HOH A O   1 
HETATM 3943 O O   . HOH C 3 .   ? 16.89956  -1.37151  -39.48409 1.000 13.29887 ? 742  HOH A O   1 
HETATM 3944 O O   . HOH C 3 .   ? 2.91540   -10.94317 -4.00458  1.000 16.88318 ? 743  HOH A O   1 
HETATM 3945 O O   . HOH C 3 .   ? -4.68059  -16.99182 -13.08578 1.000 27.64552 ? 744  HOH A O   1 
HETATM 3946 O O   . HOH C 3 .   ? -6.41345  -15.42825 -11.81202 1.000 27.43488 ? 745  HOH A O   1 
HETATM 3947 O O   . HOH C 3 .   ? 21.05375  -13.57919 8.15035   1.000 18.22367 ? 746  HOH A O   1 
HETATM 3948 O O   . HOH C 3 .   ? 28.86758  -5.53588  -37.68298 1.000 19.44045 ? 747  HOH A O   1 
HETATM 3949 O O   . HOH C 3 .   ? 16.71303  -28.41920 -24.20230 1.000 16.09318 ? 748  HOH A O   1 
HETATM 3950 O O   . HOH C 3 .   ? 17.62573  6.53049   -15.65459 1.000 26.64992 ? 749  HOH A O   1 
HETATM 3951 O O   . HOH C 3 .   ? 0.94414   -9.71580  -33.41458 1.000 17.77274 ? 750  HOH A O   1 
HETATM 3952 O O   . HOH C 3 .   ? 16.949    5.201     8.252     1.000 13.50283 ? 751  HOH A O   1 
HETATM 3953 O O   A HOH C 3 .   ? 27.23122  -23.62851 -19.14131 0.599 9.34491  ? 752  HOH A O   1 
HETATM 3954 O O   B HOH C 3 .   ? 28.25566  -22.91205 -18.96915 0.401 16.23972 ? 752  HOH A O   1 
HETATM 3955 O O   . HOH C 3 .   ? 23.88228  -10.01121 7.63910   1.000 20.08320 ? 753  HOH A O   1 
HETATM 3956 O O   . HOH C 3 .   ? 9.52083   -4.64803  -29.08908 1.000 8.98114  ? 754  HOH A O   1 
HETATM 3957 O O   . HOH C 3 .   ? 19.11910  3.45476   -5.04046  1.000 16.95267 ? 755  HOH A O   1 
HETATM 3958 O O   . HOH C 3 .   ? 16.17444  -23.92593 5.48606   1.000 21.32973 ? 756  HOH A O   1 
HETATM 3959 O O   . HOH C 3 .   ? -3.39844  -20.46784 -18.51154 1.000 16.88687 ? 757  HOH A O   1 
HETATM 3960 O O   A HOH C 3 .   ? 32.11053  -9.62200  -6.91316  0.476 10.67331 ? 758  HOH A O   1 
HETATM 3961 O O   B HOH C 3 .   ? 33.53317  -9.77840  -6.26993  0.524 13.86784 ? 758  HOH A O   1 
HETATM 3962 O O   . HOH C 3 .   ? -0.41539  -6.36008  -10.49249 1.000 25.02332 ? 759  HOH A O   1 
HETATM 3963 O O   . HOH C 3 .   ? 1.984     -17.175   -3.072    1.000 12.69151 ? 760  HOH A O   1 
HETATM 3964 O O   . HOH C 3 .   ? 6.08178   -11.37341 -20.20324 1.000 18.13353 ? 761  HOH A O   1 
HETATM 3965 O O   . HOH C 3 .   ? 12.02303  -9.04196  -33.32734 1.000 13.33188 ? 762  HOH A O   1 
HETATM 3966 O O   . HOH C 3 .   ? 7.73468   4.97247   -10.73607 1.000 16.25556 ? 763  HOH A O   1 
HETATM 3967 O O   . HOH C 3 .   ? 27.82824  -25.19334 -26.79624 1.000 17.10227 ? 764  HOH A O   1 
HETATM 3968 O O   . HOH C 3 .   ? 9.81467   7.28738   -13.32879 1.000 17.11296 ? 765  HOH A O   1 
HETATM 3969 O O   . HOH C 3 .   ? 25.46081  0.73674   12.05651  1.000 16.16145 ? 766  HOH A O   1 
HETATM 3970 O O   . HOH C 3 .   ? 23.89595  3.47847   -17.86052 1.000 26.77445 ? 767  HOH A O   1 
HETATM 3971 O O   . HOH C 3 .   ? 9.98388   -23.39331 -26.43542 1.000 26.66919 ? 768  HOH A O   1 
HETATM 3972 O O   . HOH C 3 .   ? 35.09961  3.73351   -6.42501  1.000 22.81515 ? 769  HOH A O   1 
HETATM 3973 O O   . HOH C 3 .   ? -3.11629  -0.45648  -15.74348 1.000 18.83536 ? 770  HOH A O   1 
HETATM 3974 O O   A HOH C 3 .   ? -0.30035  -11.23689 -31.29134 0.748 17.23433 ? 771  HOH A O   1 
HETATM 3975 O O   B HOH C 3 .   ? -1.65120  -10.97825 -30.42082 0.252 15.58526 ? 771  HOH A O   1 
HETATM 3976 O O   . HOH C 3 .   ? 23.18033  8.68753   -9.83377  1.000 21.54303 ? 772  HOH A O   1 
HETATM 3977 O O   . HOH C 3 .   ? 18.11122  7.10444   -19.38299 1.000 22.78142 ? 773  HOH A O   1 
HETATM 3978 O O   . HOH C 3 .   ? 18.25565  -27.19650 -27.40963 1.000 23.89054 ? 774  HOH A O   1 
HETATM 3979 O O   . HOH C 3 .   ? 4.06142   -23.53901 -20.30321 1.000 17.58052 ? 775  HOH A O   1 
HETATM 3980 O O   . HOH C 3 .   ? 42.54443  -17.67142 -11.08052 1.000 22.75690 ? 776  HOH A O   1 
HETATM 3981 O O   A HOH C 3 .   ? 22.88882  -27.81064 -0.54841  0.662 22.51530 ? 777  HOH A O   1 
HETATM 3982 O O   B HOH C 3 .   ? 22.09611  -28.69612 -2.93554  0.338 18.26511 ? 777  HOH A O   1 
HETATM 3983 O O   . HOH C 3 .   ? -5.55162  -5.14502  -14.42183 1.000 22.00459 ? 778  HOH A O   1 
HETATM 3984 O O   . HOH C 3 .   ? 34.08644  -5.34685  -2.29787  1.000 11.70205 ? 779  HOH A O   1 
HETATM 3985 O O   . HOH C 3 .   ? 10.53024  -30.79534 -9.30536  1.000 12.59722 ? 780  HOH A O   1 
HETATM 3986 O O   . HOH C 3 .   ? -0.85904  -21.36509 -24.62423 1.000 26.05398 ? 781  HOH A O   1 
HETATM 3987 O O   . HOH C 3 .   ? 7.05305   -13.21547 -13.62371 1.000 11.86020 ? 782  HOH A O   1 
HETATM 3988 O O   . HOH C 3 .   ? 5.50428   -9.83736  2.00464   1.000 18.31581 ? 783  HOH A O   1 
HETATM 3989 O O   . HOH C 3 .   ? 14.46715  -0.00833  -30.82485 1.000 9.72801  ? 784  HOH A O   1 
HETATM 3990 O O   A HOH C 3 .   ? 30.43916  -21.51603 -24.10706 0.765 14.57758 ? 785  HOH A O   1 
HETATM 3991 O O   B HOH C 3 .   ? 29.62966  -22.48858 -25.36321 0.235 16.20084 ? 785  HOH A O   1 
HETATM 3992 O O   . HOH C 3 .   ? -12.76109 -3.27062  -20.65081 1.000 17.35409 ? 786  HOH A O   1 
HETATM 3993 O O   A HOH C 3 .   ? 25.50251  -0.79685  -36.15311 0.465 11.83638 ? 787  HOH A O   1 
HETATM 3994 O O   B HOH C 3 .   ? 26.73480  -0.93862  -36.85892 0.535 13.43458 ? 787  HOH A O   1 
HETATM 3995 O O   . HOH C 3 .   ? 23.53813  7.00370   -2.30462  1.000 27.24461 ? 788  HOH A O   1 
HETATM 3996 O O   . HOH C 3 .   ? 17.33926  -8.29259  5.06365   1.000 15.81754 ? 789  HOH A O   1 
HETATM 3997 O O   . HOH C 3 .   ? 20.56298  -19.23191 4.76801   1.000 15.35297 ? 790  HOH A O   1 
HETATM 3998 O O   . HOH C 3 .   ? -1.24964  5.22130   -17.06933 1.000 19.97986 ? 791  HOH A O   1 
HETATM 3999 O O   . HOH C 3 .   ? 28.00095  -8.16857  -39.04807 1.000 28.76736 ? 792  HOH A O   1 
HETATM 4000 O O   . HOH C 3 .   ? 24.42770  0.64285   -36.99351 1.000 16.15246 ? 793  HOH A O   1 
HETATM 4001 O O   . HOH C 3 .   ? 17.50740  -4.55655  -34.32717 1.000 10.88446 ? 794  HOH A O   1 
HETATM 4002 O O   . HOH C 3 .   ? 8.50563   -17.40901 -12.40395 1.000 10.70514 ? 795  HOH A O   1 
HETATM 4003 O O   . HOH C 3 .   ? 33.74071  9.79331   -17.87568 1.000 11.11920 ? 796  HOH A O   1 
HETATM 4004 O O   . HOH C 3 .   ? 29.15431  7.06954   -17.96985 1.000 12.96682 ? 797  HOH A O   1 
HETATM 4005 O O   A HOH C 3 .   ? 25.81870  6.00128   -18.77525 0.665 14.98547 ? 798  HOH A O   1 
HETATM 4006 O O   B HOH C 3 .   ? 26.55763  3.30884   -19.38188 0.335 12.41153 ? 798  HOH A O   1 
HETATM 4007 O O   . HOH C 3 .   ? 26.91364  -26.95763 -0.57096  1.000 19.41234 ? 799  HOH A O   1 
HETATM 4008 O O   . HOH C 3 .   ? 33.56305  3.67897   -15.88435 1.000 12.69084 ? 800  HOH A O   1 
HETATM 4009 O O   . HOH C 3 .   ? 13.45538  -3.09337  -2.50595  1.000 12.54657 ? 801  HOH A O   1 
HETATM 4010 O O   . HOH C 3 .   ? 13.54360  -17.69038 4.56480   1.000 10.61724 ? 802  HOH A O   1 
HETATM 4011 O O   . HOH C 3 .   ? 12.68582  -19.72750 -19.96122 1.000 9.69007  ? 803  HOH A O   1 
HETATM 4012 O O   . HOH C 3 .   ? 21.75736  2.31154   -12.92721 1.000 18.45824 ? 804  HOH A O   1 
HETATM 4013 O O   . HOH C 3 .   ? 12.23553  -6.41164  -21.61136 1.000 8.74297  ? 805  HOH A O   1 
HETATM 4014 O O   . HOH C 3 .   ? 11.27392  -9.00671  -21.38461 1.000 8.19550  ? 806  HOH A O   1 
HETATM 4015 O O   A HOH C 3 .   ? 7.446     -6.940    -35.437   0.373 10.26493 ? 807  HOH A O   1 
HETATM 4016 O O   B HOH C 3 .   ? 9.417     -0.339    -36.114   0.300 9.39644  ? 807  HOH A O   1 
HETATM 4017 O O   C HOH C 3 .   ? 9.490     -1.155    -36.397   0.137 8.83444  ? 807  HOH A O   1 
HETATM 4018 O O   D HOH C 3 .   ? 8.202     -6.506    -35.749   0.189 9.59522  ? 807  HOH A O   1 
HETATM 4019 O O   . HOH C 3 .   ? -3.41130  -7.04092  -14.37385 1.000 15.05163 ? 808  HOH A O   1 
HETATM 4020 O O   . HOH C 3 .   ? 11.55254  -17.32505 -19.46615 1.000 7.70472  ? 809  HOH A O   1 
HETATM 4021 O O   . HOH C 3 .   ? 7.28926   -18.67131 -15.09200 1.000 11.76223 ? 810  HOH A O   1 
HETATM 4022 O O   . HOH C 3 .   ? 10.56671  -19.69268 -29.48035 1.000 13.34749 ? 811  HOH A O   1 
HETATM 4023 O O   . HOH C 3 .   ? 26.11934  5.74690   -39.58627 1.000 17.01974 ? 812  HOH A O   1 
HETATM 4024 O O   . HOH C 3 .   ? 21.97948  -2.03538  -8.96704  1.000 10.35605 ? 813  HOH A O   1 
HETATM 4025 O O   . HOH C 3 .   ? 41.30085  -11.86278 -13.03972 1.000 26.24066 ? 814  HOH A O   1 
HETATM 4026 O O   . HOH C 3 .   ? -6.33794  -18.32851 -24.68420 1.000 17.91429 ? 815  HOH A O   1 
HETATM 4027 O O   . HOH C 3 .   ? 13.27553  -8.20722  -24.63761 1.000 8.26500  ? 816  HOH A O   1 
HETATM 4028 O O   . HOH C 3 .   ? 5.16058   -29.49472 -2.10408  1.000 12.40723 ? 817  HOH A O   1 
HETATM 4029 O O   . HOH C 3 .   ? 21.41642  5.84602   -30.27129 1.000 10.67129 ? 818  HOH A O   1 
HETATM 4030 O O   . HOH C 3 .   ? 8.94266   -30.87736 -1.08874  1.000 23.65766 ? 819  HOH A O   1 
HETATM 4031 O O   . HOH C 3 .   ? 20.08188  -3.69122  -34.51058 1.000 10.43913 ? 820  HOH A O   1 
HETATM 4032 O O   . HOH C 3 .   ? 13.70921  1.53137   2.63158   1.000 26.39138 ? 821  HOH A O   1 
HETATM 4033 O O   . HOH C 3 .   ? 12.49075  5.76242   -22.10431 1.000 14.81786 ? 822  HOH A O   1 
HETATM 4034 O O   . HOH C 3 .   ? 27.79614  1.41816   -37.27276 1.000 16.65729 ? 823  HOH A O   1 
HETATM 4035 O O   . HOH C 3 .   ? 40.15126  -9.91905  -14.72979 1.000 20.70385 ? 824  HOH A O   1 
HETATM 4036 O O   A HOH C 3 .   ? 40.69222  -20.54955 -14.37569 0.667 14.55162 ? 825  HOH A O   1 
HETATM 4037 O O   B HOH C 3 .   ? 39.05290  -22.40054 -15.13575 0.333 12.76376 ? 825  HOH A O   1 
HETATM 4038 O O   . HOH C 3 .   ? -1.01731  5.28301   -21.38747 1.000 16.71409 ? 826  HOH A O   1 
HETATM 4039 O O   . HOH C 3 .   ? 18.95195  -25.74438 -8.64359  1.000 9.46133  ? 827  HOH A O   1 
HETATM 4040 O O   . HOH C 3 .   ? 26.38754  -26.93307 -4.00183  1.000 13.76414 ? 828  HOH A O   1 
HETATM 4041 O O   . HOH C 3 .   ? 21.77763  -28.17886 -8.53129  1.000 9.67302  ? 829  HOH A O   1 
HETATM 4042 O O   . HOH C 3 .   ? 17.65260  -18.16547 -32.64214 1.000 24.20531 ? 830  HOH A O   1 
HETATM 4043 O O   . HOH C 3 .   ? 2.93192   -17.72249 -33.93647 1.000 29.90845 ? 831  HOH A O   1 
HETATM 4044 O O   . HOH C 3 .   ? 10.77322  -33.12288 -16.51912 1.000 14.31674 ? 832  HOH A O   1 
HETATM 4045 O O   . HOH C 3 .   ? 31.10976  -22.86284 -26.90267 1.000 25.58889 ? 833  HOH A O   1 
HETATM 4046 O O   . HOH C 3 .   ? 11.389    -2.453    3.281     1.000 19.45053 ? 834  HOH A O   1 
HETATM 4047 O O   A HOH C 3 .   ? 25.31985  -7.81328  -12.86097 0.821 9.15510  ? 835  HOH A O   1 
HETATM 4048 O O   B HOH C 3 .   ? 25.74792  -7.89871  -13.27433 0.179 11.02450 ? 835  HOH A O   1 
HETATM 4049 O O   . HOH C 3 .   ? 40.56798  -12.78908 -21.81230 1.000 20.85930 ? 836  HOH A O   1 
HETATM 4050 O O   A HOH C 3 .   ? 29.98813  -24.60464 -15.35136 0.778 9.15547  ? 837  HOH A O   1 
HETATM 4051 O O   B HOH C 3 .   ? 29.36129  -24.23070 -15.65514 0.222 10.59325 ? 837  HOH A O   1 
HETATM 4052 O O   A HOH C 3 .   ? 22.88031  -18.25388 3.18795   0.678 13.76844 ? 838  HOH A O   1 
HETATM 4053 O O   B HOH C 3 .   ? 23.08611  -18.56531 4.52185   0.322 14.52330 ? 838  HOH A O   1 
HETATM 4054 O O   . HOH C 3 .   ? 8.08507   -21.77290 2.39016   1.000 10.63544 ? 839  HOH A O   1 
HETATM 4055 O O   . HOH C 3 .   ? 15.25798  12.46515  -19.74323 1.000 24.96767 ? 840  HOH A O   1 
HETATM 4056 O O   . HOH C 3 .   ? 20.47781  4.83551   -1.88844  1.000 27.62003 ? 841  HOH A O   1 
HETATM 4057 O O   . HOH C 3 .   ? 16.29913  -31.34879 -9.68301  1.000 24.46188 ? 842  HOH A O   1 
HETATM 4058 O O   A HOH C 3 .   ? 23.23035  -29.36929 -23.02418 0.694 10.00781 ? 843  HOH A O   1 
HETATM 4059 O O   B HOH C 3 .   ? 23.46063  -28.84014 -23.71881 0.306 10.56431 ? 843  HOH A O   1 
HETATM 4060 O O   . HOH C 3 .   ? 30.58603  -10.41728 -32.96814 1.000 14.63048 ? 844  HOH A O   1 
HETATM 4061 O O   . HOH C 3 .   ? -9.41361  -3.46678  -25.38243 1.000 18.08924 ? 845  HOH A O   1 
HETATM 4062 O O   . HOH C 3 .   ? -1.53145  8.98315   -24.48100 1.000 18.71129 ? 846  HOH A O   1 
HETATM 4063 O O   . HOH C 3 .   ? 17.69201  -2.26034  -2.25602  1.000 10.32955 ? 847  HOH A O   1 
HETATM 4064 O O   . HOH C 3 .   ? 18.41516  -4.89561  -16.75374 1.000 11.80825 ? 848  HOH A O   1 
HETATM 4065 O O   . HOH C 3 .   ? 1.08760   8.81827   -14.43336 1.000 23.54347 ? 849  HOH A O   1 
HETATM 4066 O O   . HOH C 3 .   ? 13.45883  -5.53644  4.52138   1.000 14.72949 ? 850  HOH A O   1 
HETATM 4067 O O   . HOH C 3 .   ? 33.20894  3.26449   -23.84542 1.000 10.18819 ? 851  HOH A O   1 
HETATM 4068 O O   . HOH C 3 .   ? 9.55186   -19.98908 -12.42647 1.000 10.77945 ? 852  HOH A O   1 
HETATM 4069 O O   A HOH C 3 .   ? 1.328     -27.656   -7.019    0.539 17.74611 ? 853  HOH A O   1 
HETATM 4070 O O   B HOH C 3 .   ? 1.227     -27.664   -6.522    0.461 10.33925 ? 853  HOH A O   1 
HETATM 4071 O O   A HOH C 3 .   ? 37.72010  -4.09751  -25.35610 0.589 9.08523  ? 854  HOH A O   1 
HETATM 4072 O O   B HOH C 3 .   ? 37.55072  -4.48872  -25.84274 0.411 7.96234  ? 854  HOH A O   1 
HETATM 4073 O O   . HOH C 3 .   ? 20.99086  -15.42978 -33.33568 1.000 20.12667 ? 855  HOH A O   1 
HETATM 4074 O O   . HOH C 3 .   ? 29.68962  -24.29566 -24.07775 1.000 21.46132 ? 856  HOH A O   1 
HETATM 4075 O O   . HOH C 3 .   ? 14.934    -34.975   -17.011   1.000 15.44500 ? 857  HOH A O   1 
HETATM 4076 O O   . HOH C 3 .   ? -0.04386  -18.10430 -27.74611 1.000 19.99250 ? 858  HOH A O   1 
HETATM 4077 O O   . HOH C 3 .   ? 2.75424   -20.78711 -5.32267  1.000 15.03405 ? 859  HOH A O   1 
HETATM 4078 O O   . HOH C 3 .   ? 1.86355   7.62235   -11.62466 1.000 28.83351 ? 860  HOH A O   1 
HETATM 4079 O O   . HOH C 3 .   ? 8.97824   15.29703  -20.21183 1.000 25.04265 ? 861  HOH A O   1 
HETATM 4080 O O   . HOH C 3 .   ? 8.28030   -20.81999 -24.05181 1.000 13.48068 ? 862  HOH A O   1 
HETATM 4081 O O   . HOH C 3 .   ? 21.65405  -5.08009  9.79884   1.000 25.28283 ? 863  HOH A O   1 
HETATM 4082 O O   . HOH C 3 .   ? 6.53188   -3.97985  -19.66662 1.000 11.06529 ? 864  HOH A O   1 
HETATM 4083 O O   . HOH C 3 .   ? 25.39688  -23.68400 -24.72345 1.000 13.70330 ? 865  HOH A O   1 
HETATM 4084 O O   . HOH C 3 .   ? -4.76467  -18.57967 -19.93003 1.000 25.38513 ? 866  HOH A O   1 
HETATM 4085 O O   . HOH C 3 .   ? 8.78246   -3.16121  -13.90941 1.000 22.71550 ? 867  HOH A O   1 
HETATM 4086 O O   . HOH C 3 .   ? 19.19637  -3.53070  9.78541   1.000 26.15841 ? 868  HOH A O   1 
HETATM 4087 O O   . HOH C 3 .   ? 22.73271  1.94891   -24.64332 1.000 16.61121 ? 869  HOH A O   1 
HETATM 4088 O O   . HOH C 3 .   ? 17.50513  2.29580   3.07603   1.000 21.53951 ? 870  HOH A O   1 
HETATM 4089 O O   . HOH C 3 .   ? 10.67726  -10.16699 -37.48635 1.000 32.96029 ? 871  HOH A O   1 
HETATM 4090 O O   . HOH C 3 .   ? 3.85176   -1.91965  -25.78381 1.000 12.28683 ? 872  HOH A O   1 
HETATM 4091 O O   . HOH C 3 .   ? 15.04243  -1.14707  4.72315   1.000 15.80855 ? 873  HOH A O   1 
HETATM 4092 O O   . HOH C 3 .   ? 27.86034  -12.64611 6.85621   1.000 22.04998 ? 874  HOH A O   1 
HETATM 4093 O O   . HOH C 3 .   ? -0.19170  -20.12023 -15.86352 1.000 13.08033 ? 875  HOH A O   1 
HETATM 4094 O O   A HOH C 3 .   ? 5.47181   -26.36746 -14.58496 0.542 13.60135 ? 876  HOH A O   1 
HETATM 4095 O O   B HOH C 3 .   ? 4.94054   -26.20919 -13.89491 0.458 12.26200 ? 876  HOH A O   1 
HETATM 4096 O O   . HOH C 3 .   ? 23.58306  4.96597   0.92179   1.000 14.11671 ? 877  HOH A O   1 
HETATM 4097 O O   . HOH C 3 .   ? 27.70338  2.08471   5.88966   1.000 21.49479 ? 878  HOH A O   1 
HETATM 4098 O O   . HOH C 3 .   ? 33.13165  1.89638   -3.73777  1.000 13.15317 ? 879  HOH A O   1 
HETATM 4099 O O   . HOH C 3 .   ? 24.67650  -5.50385  -14.40538 1.000 8.51877  ? 880  HOH A O   1 
HETATM 4100 O O   . HOH C 3 .   ? 5.82989   -32.09436 -3.06065  1.000 14.17729 ? 881  HOH A O   1 
HETATM 4101 O O   . HOH C 3 .   ? 35.90333  -0.03476  -16.39026 1.000 22.86726 ? 882  HOH A O   1 
HETATM 4102 O O   . HOH C 3 .   ? 37.21087  -21.82302 -21.24494 1.000 15.60287 ? 883  HOH A O   1 
HETATM 4103 O O   . HOH C 3 .   ? 34.05191  1.21460   -20.24733 1.000 12.56315 ? 884  HOH A O   1 
HETATM 4104 O O   . HOH C 3 .   ? 16.45201  -13.57574 8.83372   1.000 20.60867 ? 885  HOH A O   1 
HETATM 4105 O O   . HOH C 3 .   ? -0.97857  -11.05964 -9.45129  1.000 20.88661 ? 886  HOH A O   1 
HETATM 4106 O O   . HOH C 3 .   ? 19.70671  -5.16529  -20.44702 1.000 12.28879 ? 887  HOH A O   1 
HETATM 4107 O O   . HOH C 3 .   ? 32.70501  0.82393   -31.91638 1.000 12.43135 ? 888  HOH A O   1 
HETATM 4108 O O   . HOH C 3 .   ? 4.02116   -21.91398 -23.72907 1.000 18.24544 ? 889  HOH A O   1 
HETATM 4109 O O   . HOH C 3 .   ? 30.63868  -28.52747 -21.50012 1.000 21.81747 ? 890  HOH A O   1 
HETATM 4110 O O   . HOH C 3 .   ? 13.28480  11.34972  -28.19531 1.000 21.85383 ? 891  HOH A O   1 
HETATM 4111 O O   . HOH C 3 .   ? 18.49095  -24.97207 -6.07710  1.000 12.67356 ? 892  HOH A O   1 
HETATM 4112 O O   . HOH C 3 .   ? 2.26618   -15.00964 -5.12859  1.000 18.17538 ? 893  HOH A O   1 
HETATM 4113 O O   . HOH C 3 .   ? 20.94993  9.04811   -37.09304 1.000 22.02955 ? 894  HOH A O   1 
HETATM 4114 O O   . HOH C 3 .   ? 7.15758   -12.70753 -5.92493  1.000 23.62660 ? 895  HOH A O   1 
HETATM 4115 O O   . HOH C 3 .   ? 2.50004   -17.04302 -15.88569 1.000 10.44415 ? 896  HOH A O   1 
HETATM 4116 O O   . HOH C 3 .   ? 5.53588   -5.90396  -6.59985  1.000 35.78910 ? 897  HOH A O   1 
HETATM 4117 O O   A HOH C 3 .   ? 3.37700   -24.03577 -13.43715 0.545 10.09579 ? 898  HOH A O   1 
HETATM 4118 O O   B HOH C 3 .   ? 3.61580   -24.45537 -14.06736 0.455 12.74889 ? 898  HOH A O   1 
HETATM 4119 O O   . HOH C 3 .   ? 21.949    6.420     -26.234   1.000 13.85821 ? 899  HOH A O   1 
HETATM 4120 O O   . HOH C 3 .   ? 24.53304  -12.66002 7.11365   1.000 20.60738 ? 900  HOH A O   1 
HETATM 4121 O O   . HOH C 3 .   ? 37.46234  2.01137   -9.63172  1.000 25.76556 ? 901  HOH A O   1 
HETATM 4122 O O   . HOH C 3 .   ? 27.14939  -27.21856 -14.83481 1.000 10.99603 ? 902  HOH A O   1 
HETATM 4123 O O   . HOH C 3 .   ? -3.98957  -16.86029 -16.09786 1.000 17.57941 ? 903  HOH A O   1 
HETATM 4124 O O   . HOH C 3 .   ? 13.44563  -2.53755  -30.16170 1.000 9.26562  ? 904  HOH A O   1 
HETATM 4125 O O   . HOH C 3 .   ? 28.04915  -27.98012 -18.60708 1.000 11.97691 ? 905  HOH A O   1 
HETATM 4126 O O   . HOH C 3 .   ? 12.05820  -12.89373 7.57387   1.000 15.63267 ? 906  HOH A O   1 
HETATM 4127 O O   . HOH C 3 .   ? 3.25110   0.77011   -26.18490 1.000 12.67954 ? 907  HOH A O   1 
HETATM 4128 O O   . HOH C 3 .   ? 13.83806  -9.33343  6.90988   1.000 21.26443 ? 908  HOH A O   1 
HETATM 4129 O O   . HOH C 3 .   ? -0.61415  -3.50274  -10.29474 1.000 24.34945 ? 909  HOH A O   1 
HETATM 4130 O O   A HOH C 3 .   ? 23.505    11.445    -27.839   0.613 9.63592  ? 910  HOH A O   1 
HETATM 4131 O O   B HOH C 3 .   ? 24.410    11.944    -27.366   0.387 11.40431 ? 910  HOH A O   1 
HETATM 4132 O O   . HOH C 3 .   ? 27.65024  6.70382   -32.18651 1.000 11.88012 ? 911  HOH A O   1 
HETATM 4133 O O   . HOH C 3 .   ? -10.83098 -1.30014  -25.97581 1.000 27.54497 ? 912  HOH A O   1 
HETATM 4134 O O   . HOH C 3 .   ? 19.83305  -1.27772  8.84602   1.000 16.75211 ? 913  HOH A O   1 
HETATM 4135 O O   . HOH C 3 .   ? 16.00282  -11.26029 -32.73372 1.000 12.67795 ? 914  HOH A O   1 
HETATM 4136 O O   . HOH C 3 .   ? 8.98068   -25.95177 -19.69392 1.000 18.63295 ? 915  HOH A O   1 
HETATM 4137 O O   . HOH C 3 .   ? 14.19851  12.32659  -12.96133 1.000 22.52301 ? 916  HOH A O   1 
HETATM 4138 O O   . HOH C 3 .   ? 10.989    2.650     -37.398   1.000 26.16636 ? 917  HOH A O   1 
HETATM 4139 O O   A HOH C 3 .   ? 9.54238   -11.62014 3.96654   0.668 13.45600 ? 918  HOH A O   1 
HETATM 4140 O O   B HOH C 3 .   ? 9.13706   -11.40357 5.21063   0.332 13.44140 ? 918  HOH A O   1 
HETATM 4141 O O   . HOH C 3 .   ? 11.61296  4.44603   -12.86300 1.000 19.39162 ? 919  HOH A O   1 
HETATM 4142 O O   A HOH C 3 .   ? 17.89869  -27.58975 -1.78520  0.747 17.17896 ? 920  HOH A O   1 
HETATM 4143 O O   B HOH C 3 .   ? 17.50670  -26.94900 -3.10832  0.253 12.67487 ? 920  HOH A O   1 
HETATM 4144 O O   . HOH C 3 .   ? 7.71733   -10.12086 -21.44470 1.000 16.88386 ? 921  HOH A O   1 
HETATM 4145 O O   . HOH C 3 .   ? 27.933    -22.110   4.667     1.000 23.92472 ? 922  HOH A O   1 
HETATM 4146 O O   . HOH C 3 .   ? 12.22076  -11.26423 -30.15272 1.000 9.45815  ? 923  HOH A O   1 
HETATM 4147 O O   . HOH C 3 .   ? 17.98558  7.98612   -22.16275 1.000 23.28459 ? 924  HOH A O   1 
HETATM 4148 O O   . HOH C 3 .   ? 2.942     -31.147   -17.724   1.000 28.05121 ? 925  HOH A O   1 
HETATM 4149 O O   . HOH C 3 .   ? 13.09613  -25.08726 -24.88204 1.000 16.42461 ? 926  HOH A O   1 
HETATM 4150 O O   . HOH C 3 .   ? 0.64106   4.79564   -10.38792 1.000 26.27441 ? 927  HOH A O   1 
HETATM 4151 O O   . HOH C 3 .   ? -2.926    -17.745   -7.769    1.000 25.59217 ? 928  HOH A O   1 
HETATM 4152 O O   A HOH C 3 .   ? 15.83230  -10.22058 9.11777   0.624 22.14466 ? 929  HOH A O   1 
HETATM 4153 O O   B HOH C 3 .   ? 14.03668  -12.34888 9.36043   0.376 11.68352 ? 929  HOH A O   1 
HETATM 4154 O O   . HOH C 3 .   ? 16.79082  -35.64290 -15.16936 1.000 20.81338 ? 930  HOH A O   1 
HETATM 4155 O O   . HOH C 3 .   ? 25.78929  10.20146  -8.96293  1.000 16.66763 ? 931  HOH A O   1 
HETATM 4156 O O   . HOH C 3 .   ? 21.65894  -19.05861 -35.83545 1.000 23.35563 ? 932  HOH A O   1 
HETATM 4157 O O   . HOH C 3 .   ? 22.195    -26.453   -25.038   1.000 13.15081 ? 933  HOH A O   1 
HETATM 4158 O O   . HOH C 3 .   ? 26.68563  -1.18034  3.63540   1.000 13.34955 ? 934  HOH A O   1 
HETATM 4159 O O   . HOH C 3 .   ? 20.480    -3.353    11.898    1.000 26.90600 ? 935  HOH A O   1 
HETATM 4160 O O   A HOH C 3 .   ? 18.82033  -1.73140  -19.80921 0.618 17.87865 ? 936  HOH A O   1 
HETATM 4161 O O   B HOH C 3 .   ? 18.09430  -3.01424  -19.82545 0.382 12.44349 ? 936  HOH A O   1 
HETATM 4162 O O   . HOH C 3 .   ? 11.72957  -5.30657  -10.06392 1.000 20.06300 ? 937  HOH A O   1 
HETATM 4163 O O   . HOH C 3 .   ? 4.12422   -8.76461  -4.86783  1.000 23.53879 ? 938  HOH A O   1 
HETATM 4164 O O   . HOH C 3 .   ? 29.38855  -18.99570 -32.89882 1.000 21.81098 ? 939  HOH A O   1 
HETATM 4165 O O   A HOH C 3 .   ? 6.146     14.454    -22.104   0.779 17.05057 ? 940  HOH A O   1 
HETATM 4166 O O   B HOH C 3 .   ? 4.992     14.662    -21.581   0.221 14.65655 ? 940  HOH A O   1 
HETATM 4167 O O   . HOH C 3 .   ? 0.53509   7.44999   -30.50092 1.000 20.81934 ? 941  HOH A O   1 
HETATM 4168 O O   . HOH C 3 .   ? 5.92369   -11.18974 -12.25283 1.000 14.35354 ? 942  HOH A O   1 
HETATM 4169 O O   A HOH C 3 .   ? 20.21523  0.70232   -21.48249 0.443 16.79447 ? 943  HOH A O   1 
HETATM 4170 O O   B HOH C 3 .   ? 21.94586  1.29100   -21.97717 0.557 15.49671 ? 943  HOH A O   1 
HETATM 4171 O O   . HOH C 3 .   ? 16.80597  10.63505  -35.70611 1.000 20.64265 ? 944  HOH A O   1 
HETATM 4172 O O   . HOH C 3 .   ? -14.29645 -10.45383 -20.13771 1.000 21.26170 ? 945  HOH A O   1 
HETATM 4173 O O   . HOH C 3 .   ? 29.16123  -25.58403 -17.87970 1.000 12.73014 ? 946  HOH A O   1 
HETATM 4174 O O   . HOH C 3 .   ? 9.15732   -31.74502 -18.47827 1.000 19.07620 ? 947  HOH A O   1 
HETATM 4175 O O   . HOH C 3 .   ? 2.42449   8.07895   -25.25435 1.000 20.85284 ? 948  HOH A O   1 
HETATM 4176 O O   . HOH C 3 .   ? 1.07601   1.50714   -27.86102 1.000 20.73473 ? 949  HOH A O   1 
HETATM 4177 O O   . HOH C 3 .   ? 18.74331  -7.37597  8.12758   1.000 23.45926 ? 950  HOH A O   1 
HETATM 4178 O O   . HOH C 3 .   ? -4.63962  -15.93667 -18.47139 1.000 17.20520 ? 951  HOH A O   1 
HETATM 4179 O O   A HOH C 3 .   ? 33.905    0.517     -29.486   0.701 9.55585  ? 952  HOH A O   1 
HETATM 4180 O O   B HOH C 3 .   ? 33.736    1.061     -29.266   0.299 9.48419  ? 952  HOH A O   1 
HETATM 4181 O O   . HOH C 3 .   ? 30.37866  3.98308   0.15857   1.000 23.55355 ? 953  HOH A O   1 
HETATM 4182 O O   A HOH C 3 .   ? 7.94514   -10.80790 -10.50843 0.727 9.82101  ? 954  HOH A O   1 
HETATM 4183 O O   B HOH C 3 .   ? 8.34443   -10.41353 -11.08906 0.273 10.91821 ? 954  HOH A O   1 
HETATM 4184 O O   . HOH C 3 .   ? 19.09826  -4.49689  -31.22248 1.000 9.98593  ? 955  HOH A O   1 
HETATM 4185 O O   . HOH C 3 .   ? 23.06373  3.68726   9.67252   1.000 15.82020 ? 956  HOH A O   1 
HETATM 4186 O O   . HOH C 3 .   ? 23.254    -3.189    12.766    1.000 20.92879 ? 957  HOH A O   1 
HETATM 4187 O O   . HOH C 3 .   ? 6.43892   -23.46792 -18.82154 1.000 21.30101 ? 958  HOH A O   1 
HETATM 4188 O O   . HOH C 3 .   ? -3.13576  1.69608   -18.96500 1.000 15.65764 ? 959  HOH A O   1 
HETATM 4189 O O   A HOH C 3 .   ? 22.48237  2.42834   -16.04319 0.467 19.48721 ? 960  HOH A O   1 
HETATM 4190 O O   B HOH C 3 .   ? 20.32144  0.82972   -16.85602 0.533 22.23999 ? 960  HOH A O   1 
HETATM 4191 O O   . HOH C 3 .   ? 29.33034  -12.20716 -34.71945 1.000 19.73981 ? 961  HOH A O   1 
HETATM 4192 O O   A HOH C 3 .   ? 10.97653  -16.57132 4.34959   0.690 10.06851 ? 962  HOH A O   1 
HETATM 4193 O O   B HOH C 3 .   ? 10.13198  -16.49050 3.65542   0.310 12.85749 ? 962  HOH A O   1 
HETATM 4194 O O   . HOH C 3 .   ? 15.39213  -2.93525  -13.79311 1.000 27.67709 ? 963  HOH A O   1 
HETATM 4195 O O   . HOH C 3 .   ? 21.997    9.603     -12.260   1.000 25.54587 ? 964  HOH A O   1 
HETATM 4196 O O   . HOH C 3 .   ? -9.05841  -12.44588 -13.43023 1.000 23.89772 ? 965  HOH A O   1 
HETATM 4197 O O   . HOH C 3 .   ? 8.81575   -17.85053 -30.80538 1.000 13.19794 ? 966  HOH A O   1 
HETATM 4198 O O   . HOH C 3 .   ? 35.569    -24.442   -8.988    1.000 22.19276 ? 967  HOH A O   1 
HETATM 4199 O O   A HOH C 3 .   ? 23.89822  8.51846   -14.96121 0.583 16.96328 ? 968  HOH A O   1 
HETATM 4200 O O   B HOH C 3 .   ? 24.64410  7.71132   -16.21556 0.417 20.16267 ? 968  HOH A O   1 
HETATM 4201 O O   . HOH C 3 .   ? 7.43503   2.50979   -7.63091  1.000 32.28502 ? 969  HOH A O   1 
HETATM 4202 O O   . HOH C 3 .   ? 33.65943  -6.74873  -31.50584 1.000 14.80960 ? 970  HOH A O   1 
HETATM 4203 O O   . HOH C 3 .   ? 25.48451  3.72220   -26.72453 1.000 12.82041 ? 971  HOH A O   1 
HETATM 4204 O O   . HOH C 3 .   ? 1.25548   -18.82945 -25.43357 1.000 17.47674 ? 972  HOH A O   1 
HETATM 4205 O O   . HOH C 3 .   ? 12.07320  -23.74809 -30.74200 1.000 29.20953 ? 973  HOH A O   1 
HETATM 4206 O O   . HOH C 3 .   ? -3.35142  -0.78949  -26.26979 1.000 18.26110 ? 974  HOH A O   1 
HETATM 4207 O O   . HOH C 3 .   ? 33.81611  5.77618   -1.82537  1.000 29.79688 ? 975  HOH A O   1 
HETATM 4208 O O   . HOH C 3 .   ? 7.63775   13.66366  -24.78631 1.000 21.68588 ? 976  HOH A O   1 
HETATM 4209 O O   . HOH C 3 .   ? 38.95448  -14.51815 -29.79913 1.000 26.59073 ? 977  HOH A O   1 
HETATM 4210 O O   A HOH C 3 .   ? 17.77159  1.94088   -14.59410 0.524 21.37663 ? 978  HOH A O   1 
HETATM 4211 O O   B HOH C 3 .   ? 16.04668  2.28872   -13.53768 0.476 17.21265 ? 978  HOH A O   1 
HETATM 4212 O O   . HOH C 3 .   ? 5.72299   12.08052  -25.99568 1.000 22.50419 ? 979  HOH A O   1 
HETATM 4213 O O   . HOH C 3 .   ? 28.11608  4.94189   -0.96952  1.000 22.27335 ? 980  HOH A O   1 
HETATM 4214 O O   . HOH C 3 .   ? 19.37919  8.62741   -7.81185  1.000 34.99743 ? 981  HOH A O   1 
HETATM 4215 O O   . HOH C 3 .   ? 3.66014   -18.92553 -26.77296 1.000 24.41509 ? 982  HOH A O   1 
HETATM 4216 O O   . HOH C 3 .   ? 33.07398  3.26494   -1.23553  1.000 23.24770 ? 983  HOH A O   1 
HETATM 4217 O O   . HOH C 3 .   ? 14.70218  -7.83557  -36.66156 1.000 14.24561 ? 984  HOH A O   1 
HETATM 4218 O O   . HOH C 3 .   ? 27.56512  12.10542  -10.88505 1.000 7.28085  ? 985  HOH A O   1 
HETATM 4219 O O   . HOH C 3 .   ? 11.27037  4.70750   -36.25238 1.000 28.48071 ? 986  HOH A O   1 
HETATM 4220 O O   . HOH C 3 .   ? 8.14023   -37.40351 -9.42496  1.000 25.43664 ? 987  HOH A O   1 
HETATM 4221 O O   . HOH C 3 .   ? 19.598    7.216     -34.810   1.000 21.42618 ? 988  HOH A O   1 
HETATM 4222 O O   . HOH C 3 .   ? 27.07285  -3.88035  7.10984   1.000 19.00948 ? 989  HOH A O   1 
HETATM 4223 O O   . HOH C 3 .   ? 34.07372  5.49217   -17.95088 1.000 15.33685 ? 990  HOH A O   1 
HETATM 4224 O O   . HOH C 3 .   ? 30.21274  0.14180   -36.68346 1.000 21.14811 ? 991  HOH A O   1 
HETATM 4225 O O   . HOH C 3 .   ? 26.76827  7.77791   -2.88385  1.000 22.58517 ? 992  HOH A O   1 
HETATM 4226 O O   . HOH C 3 .   ? 14.55219  -9.60620  -34.34568 1.000 22.59040 ? 993  HOH A O   1 
HETATM 4227 O O   . HOH C 3 .   ? 38.12071  -5.79563  -13.45067 1.000 27.76411 ? 994  HOH A O   1 
HETATM 4228 O O   . HOH C 3 .   ? 33.763    -9.986    -1.793    1.000 11.34664 ? 995  HOH A O   1 
HETATM 4229 O O   . HOH C 3 .   ? 0.42835   -20.13147 -13.13024 1.000 19.08603 ? 996  HOH A O   1 
HETATM 4230 O O   A HOH C 3 .   ? -1.509    -36.992   -9.913    0.708 18.57191 ? 997  HOH A O   1 
HETATM 4231 O O   B HOH C 3 .   ? -0.389    -37.964   -10.830   0.292 13.97191 ? 997  HOH A O   1 
HETATM 4232 O O   . HOH C 3 .   ? 11.46161  -7.72172  -35.68397 1.000 18.81588 ? 998  HOH A O   1 
HETATM 4233 O O   . HOH C 3 .   ? 14.06326  3.87107   -35.85617 1.000 19.18149 ? 999  HOH A O   1 
HETATM 4234 O O   . HOH C 3 .   ? -5.78019  -0.55372  -22.04983 1.000 22.26418 ? 1000 HOH A O   1 
HETATM 4235 O O   . HOH C 3 .   ? 24.44339  -22.72046 3.04562   1.000 24.66415 ? 1001 HOH A O   1 
HETATM 4236 O O   . HOH C 3 .   ? 23.42307  4.47531   -24.95305 1.000 14.28617 ? 1002 HOH A O   1 
HETATM 4237 O O   . HOH C 3 .   ? 29.09742  -23.98180 -3.46447  1.000 12.26808 ? 1003 HOH A O   1 
HETATM 4238 O O   A HOH C 3 .   ? 41.284    -18.063   -8.729    0.731 25.21226 ? 1004 HOH A O   1 
HETATM 4239 O O   B HOH C 3 .   ? 43.751    -17.879   -8.629    0.269 16.10010 ? 1004 HOH A O   1 
HETATM 4240 O O   . HOH C 3 .   ? 34.18220  -7.91882  -3.48042  1.000 13.47231 ? 1005 HOH A O   1 
HETATM 4241 O O   . HOH C 3 .   ? 18.27745  -33.75526 -13.74527 1.000 15.38535 ? 1006 HOH A O   1 
HETATM 4242 O O   . HOH C 3 .   ? 17.64671  -16.65932 6.95949   1.000 27.32505 ? 1007 HOH A O   1 
HETATM 4243 O O   A HOH C 3 .   ? 3.862     -11.439   0.535     0.669 14.85181 ? 1008 HOH A O   1 
HETATM 4244 O O   B HOH C 3 .   ? 4.826     -12.731   0.613     0.331 13.11655 ? 1008 HOH A O   1 
HETATM 4245 O O   . HOH C 3 .   ? 20.16360  3.56819   -15.21320 1.000 31.69691 ? 1009 HOH A O   1 
HETATM 4246 O O   A HOH C 3 .   ? 26.107    -19.701   -35.319   0.661 24.26294 ? 1010 HOH A O   1 
HETATM 4247 O O   B HOH C 3 .   ? 27.088    -19.997   -35.792   0.339 17.87667 ? 1010 HOH A O   1 
HETATM 4248 O O   . HOH C 3 .   ? -14.34940 -4.96616  -29.46307 1.000 29.47564 ? 1011 HOH A O   1 
HETATM 4249 O O   . HOH C 3 .   ? 15.476    4.248     6.167     1.000 26.04076 ? 1012 HOH A O   1 
HETATM 4250 O O   . HOH C 3 .   ? 1.11463   1.71030   -24.40560 1.000 15.45894 ? 1013 HOH A O   1 
HETATM 4251 O O   . HOH C 3 .   ? 14.67109  -5.01084  -37.97541 1.000 19.55930 ? 1014 HOH A O   1 
HETATM 4252 O O   . HOH C 3 .   ? 12.53332  -1.60528  -17.62851 1.000 25.90231 ? 1015 HOH A O   1 
HETATM 4253 O O   . HOH C 3 .   ? 24.97818  -5.39443  -41.42743 1.000 36.25187 ? 1016 HOH A O   1 
HETATM 4254 O O   . HOH C 3 .   ? 17.31173  -0.25169  5.49871   1.000 21.48860 ? 1017 HOH A O   1 
HETATM 4255 O O   . HOH C 3 .   ? 2.77734   -29.51298 -19.48500 1.000 30.91862 ? 1018 HOH A O   1 
HETATM 4256 O O   A HOH C 3 .   ? 20.11028  -32.38027 -10.30310 0.531 17.25877 ? 1019 HOH A O   1 
HETATM 4257 O O   B HOH C 3 .   ? 20.40898  -34.21444 -10.28462 0.469 14.96933 ? 1019 HOH A O   1 
HETATM 4258 O O   . HOH C 3 .   ? 9.14971   -3.80427  0.32255   1.000 25.42414 ? 1020 HOH A O   1 
HETATM 4259 O O   . HOH C 3 .   ? 9.29599   -22.95912 -22.72549 1.000 18.03934 ? 1021 HOH A O   1 
HETATM 4260 O O   . HOH C 3 .   ? 20.95500  -3.21947  -19.21180 1.000 14.16025 ? 1022 HOH A O   1 
HETATM 4261 O O   . HOH C 3 .   ? 33.22990  -11.35423 -32.82589 1.000 21.78003 ? 1023 HOH A O   1 
HETATM 4262 O O   . HOH C 3 .   ? -0.83631  -12.71582 -6.98628  1.000 28.11067 ? 1024 HOH A O   1 
HETATM 4263 O O   . HOH C 3 .   ? 40.06187  -11.49296 -17.47517 1.000 21.58730 ? 1025 HOH A O   1 
HETATM 4264 O O   . HOH C 3 .   ? -8.03903  -0.13779  -24.65562 1.000 24.13676 ? 1026 HOH A O   1 
HETATM 4265 O O   A HOH C 3 .   ? 14.05872  3.06577   -38.45590 0.564 13.68177 ? 1027 HOH A O   1 
HETATM 4266 O O   B HOH C 3 .   ? 14.19712  2.91707   -39.95682 0.436 16.84370 ? 1027 HOH A O   1 
HETATM 4267 O O   . HOH C 3 .   ? 15.757    -0.074    -41.471   1.000 18.29367 ? 1028 HOH A O   1 
HETATM 4268 O O   . HOH C 3 .   ? 28.03131  -17.17330 5.26996   1.000 24.99783 ? 1029 HOH A O   1 
HETATM 4269 O O   . HOH C 3 .   ? 1.28341   11.40191  -15.47985 1.000 29.49542 ? 1030 HOH A O   1 
HETATM 4270 O O   . HOH C 3 .   ? 12.24954  -25.89735 -21.37796 1.000 30.49490 ? 1031 HOH A O   1 
HETATM 4271 O O   . HOH C 3 .   ? 26.28187  5.81105   1.00090   1.000 17.77100 ? 1032 HOH A O   1 
HETATM 4272 O O   . HOH C 3 .   ? 27.73366  5.37407   3.21097   1.000 25.85386 ? 1033 HOH A O   1 
HETATM 4273 O O   . HOH C 3 .   ? 10.82473  -2.46088  -1.43013  1.000 22.02338 ? 1034 HOH A O   1 
HETATM 4274 O O   . HOH C 3 .   ? 2.17127   7.38493   -32.84277 1.000 25.52277 ? 1035 HOH A O   1 
HETATM 4275 O O   . HOH C 3 .   ? 11.74707  -35.47803 -9.20927  1.000 25.99454 ? 1036 HOH A O   1 
HETATM 4276 O O   . HOH C 3 .   ? 2.29035   -25.89488 -17.00881 1.000 21.52485 ? 1037 HOH A O   1 
HETATM 4277 O O   . HOH C 3 .   ? -2.66028  2.41060   -13.93779 1.000 30.70282 ? 1038 HOH A O   1 
HETATM 4278 O O   . HOH C 3 .   ? 36.54447  0.85964   -18.98017 1.000 18.45792 ? 1039 HOH A O   1 
HETATM 4279 O O   . HOH C 3 .   ? 25.20006  -12.36383 -36.78934 1.000 24.75778 ? 1040 HOH A O   1 
HETATM 4280 O O   . HOH C 3 .   ? 31.25098  -16.69103 -33.34889 1.000 24.74171 ? 1041 HOH A O   1 
HETATM 4281 O O   . HOH C 3 .   ? 8.02228   6.82280   -30.38686 1.000 26.66976 ? 1042 HOH A O   1 
HETATM 4282 O O   . HOH C 3 .   ? 23.86581  2.37121   -20.57915 1.000 27.84749 ? 1043 HOH A O   1 
HETATM 4283 O O   . HOH C 3 .   ? 39.50495  -2.54028  -16.38198 1.000 28.01489 ? 1044 HOH A O   1 
HETATM 4284 O O   . HOH C 3 .   ? 3.74259   -36.09015 -1.88148  1.000 30.14364 ? 1045 HOH A O   1 
HETATM 4285 O O   . HOH C 3 .   ? 2.099     1.671     -30.483   1.000 19.90693 ? 1046 HOH A O   1 
HETATM 4286 O O   . HOH C 3 .   ? 19.283    -36.776   -10.030   1.000 24.13597 ? 1047 HOH A O   1 
HETATM 4287 O O   . HOH C 3 .   ? 12.07795  -23.58695 -22.77866 1.000 15.56949 ? 1048 HOH A O   1 
HETATM 4288 O O   . HOH C 3 .   ? 24.36632  -28.69634 -4.44897  1.000 20.91002 ? 1049 HOH A O   1 
HETATM 4289 O O   . HOH C 3 .   ? 11.43212  -13.24907 -34.71442 1.000 17.65385 ? 1050 HOH A O   1 
HETATM 4290 O O   . HOH C 3 .   ? 31.64417  -14.37142 -34.83627 1.000 30.27092 ? 1051 HOH A O   1 
HETATM 4291 O O   . HOH C 3 .   ? 24.230    -4.969    10.789    1.000 17.68675 ? 1052 HOH A O   1 
HETATM 4292 O O   . HOH C 3 .   ? 24.38755  -16.57160 -38.69772 1.000 31.51864 ? 1053 HOH A O   1 
HETATM 4293 O O   . HOH C 3 .   ? 9.14462   -22.06659 -28.77624 1.000 27.29485 ? 1054 HOH A O   1 
HETATM 4294 O O   . HOH C 3 .   ? -1.12511  7.15252   -14.87121 1.000 24.18171 ? 1055 HOH A O   1 
HETATM 4295 O O   . HOH C 3 .   ? 5.11915   -29.69930 -22.15420 1.000 29.93374 ? 1056 HOH A O   1 
HETATM 4296 O O   A HOH C 3 .   ? 19.16049  -28.42052 -8.18213  0.413 8.87072  ? 1057 HOH A O   1 
HETATM 4297 O O   B HOH C 3 .   ? 18.55849  -29.95694 -10.33204 0.587 11.08907 ? 1057 HOH A O   1 
HETATM 4298 O O   . HOH C 3 .   ? -1.89299  2.38973   -16.61707 1.000 22.01687 ? 1058 HOH A O   1 
HETATM 4299 O O   . HOH C 3 .   ? -5.31236  0.23493   -24.57708 1.000 21.18702 ? 1059 HOH A O   1 
HETATM 4300 O O   . HOH C 3 .   ? -5.93819  1.21054   -19.63361 1.000 29.32911 ? 1060 HOH A O   1 
HETATM 4301 O O   . HOH C 3 .   ? 18.34042  -15.87024 -33.77320 1.000 21.06160 ? 1061 HOH A O   1 
HETATM 4302 O O   . HOH C 3 .   ? 28.462    -11.280   9.156     1.000 22.87269 ? 1062 HOH A O   1 
HETATM 4303 O O   A HOH C 3 .   ? -0.13463  -30.79839 -12.13069 0.578 13.57344 ? 1063 HOH A O   1 
HETATM 4304 O O   C HOH C 3 .   ? 3.39029   -28.54587 -14.36658 0.422 12.56928 ? 1063 HOH A O   1 
HETATM 4305 O O   . HOH C 3 .   ? 9.11864   -6.09382  3.93573   1.000 19.67951 ? 1064 HOH A O   1 
HETATM 4306 O O   . HOH C 3 .   ? 25.95183  -9.22481  9.40268   1.000 22.67453 ? 1065 HOH A O   1 
HETATM 4307 O O   . HOH C 3 .   ? 34.472    -4.656    0.391     1.000 19.31814 ? 1066 HOH A O   1 
HETATM 4308 O O   . HOH C 3 .   ? 16.89223  -1.22414  -18.11768 1.000 24.77367 ? 1067 HOH A O   1 
HETATM 4309 O O   . HOH C 3 .   ? 23.138    7.146     -28.655   1.000 11.30568 ? 1068 HOH A O   1 
HETATM 4310 O O   . HOH C 3 .   ? 31.202    4.220     -37.125   1.000 16.76349 ? 1069 HOH A O   1 
HETATM 4311 O O   . HOH C 3 .   ? 46.04803  -17.35594 -20.46500 1.000 19.78901 ? 1070 HOH A O   1 
HETATM 4312 O O   . HOH C 3 .   ? 16.17556  -14.46127 -33.32014 1.000 20.23004 ? 1071 HOH A O   1 
HETATM 4313 O O   . HOH C 3 .   ? 35.96825  1.92594   -4.70152  1.000 27.30921 ? 1072 HOH A O   1 
HETATM 4314 O O   . HOH C 3 .   ? 3.45606   -33.59531 -3.36795  1.000 14.00230 ? 1073 HOH A O   1 
HETATM 4315 O O   . HOH C 3 .   ? 14.29419  -16.40376 -34.12108 1.000 23.59881 ? 1074 HOH A O   1 
HETATM 4316 O O   . HOH C 3 .   ? 14.91847  -17.89345 -32.31546 1.000 27.80018 ? 1075 HOH A O   1 
HETATM 4317 O O   . HOH C 3 .   ? 13.64700  -12.19515 -35.96619 1.000 26.18763 ? 1076 HOH A O   1 
HETATM 4318 O O   . HOH C 3 .   ? -11.755   -0.540    -23.675   1.000 26.47574 ? 1077 HOH A O   1 
HETATM 4319 O O   . HOH C 3 .   ? 17.348    -30.478   -26.160   1.000 23.45707 ? 1078 HOH A O   1 
HETATM 4320 O O   . HOH C 3 .   ? 35.50458  3.71928   -8.73238  1.000 22.97319 ? 1079 HOH A O   1 
HETATM 4321 O O   . HOH C 3 .   ? -3.25082  4.15317   -20.10773 1.000 18.15062 ? 1080 HOH A O   1 
HETATM 4322 O O   . HOH C 3 .   ? 0.620     11.011    -28.274   1.000 16.08861 ? 1081 HOH A O   1 
HETATM 4323 O O   . HOH C 3 .   ? 18.67972  2.49329   -40.92257 1.000 22.94034 ? 1082 HOH A O   1 
HETATM 4324 O O   . HOH C 3 .   ? 34.84343  -9.41912  -31.63319 1.000 18.80174 ? 1083 HOH A O   1 
HETATM 4325 O O   . HOH C 3 .   ? 2.947     -9.443    -1.262    1.000 25.99879 ? 1084 HOH A O   1 
HETATM 4326 O O   . HOH C 3 .   ? 36.32940  3.78872   -15.36157 1.000 26.71588 ? 1085 HOH A O   1 
HETATM 4327 O O   . HOH C 3 .   ? 6.71992   -19.42559 -31.64829 1.000 22.33807 ? 1086 HOH A O   1 
HETATM 4328 O O   . HOH C 3 .   ? 0.19646   4.07904   -23.49326 1.000 22.57675 ? 1087 HOH A O   1 
HETATM 4329 O O   . HOH C 3 .   ? -4.82571  -2.35920  -14.45095 1.000 25.64379 ? 1088 HOH A O   1 
HETATM 4330 O O   . HOH C 3 .   ? 13.66015  15.26749  -13.47980 1.000 28.54309 ? 1089 HOH A O   1 
HETATM 4331 O O   . HOH C 3 .   ? -7.35212  -16.15219 -18.41439 1.000 17.06501 ? 1090 HOH A O   1 
HETATM 4332 O O   . HOH C 3 .   ? 15.32985  -6.83502  5.93441   1.000 15.99148 ? 1091 HOH A O   1 
HETATM 4333 O O   . HOH C 3 .   ? 31.29406  -7.65912  -36.71427 1.000 36.60439 ? 1092 HOH A O   1 
HETATM 4334 O O   . HOH C 3 .   ? 3.74695   -8.43499  1.49840   1.000 33.86744 ? 1093 HOH A O   1 
HETATM 4335 O O   . HOH C 3 .   ? 25.24109  5.41363   -28.96001 1.000 10.43259 ? 1094 HOH A O   1 
HETATM 4336 O O   . HOH C 3 .   ? -0.14324  -10.13422 -35.81442 1.000 24.84254 ? 1095 HOH A O   1 
HETATM 4337 O O   . HOH C 3 .   ? 14.34364  -0.29838  -14.74753 1.000 29.02469 ? 1096 HOH A O   1 
HETATM 4338 O O   . HOH C 3 .   ? 36.23050  -6.13536  -30.69510 1.000 21.78674 ? 1097 HOH A O   1 
HETATM 4339 O O   . HOH C 3 .   ? -17.38348 -8.17260  -29.09045 1.000 18.96786 ? 1098 HOH A O   1 
HETATM 4340 O O   . HOH C 3 .   ? -3.91626  5.69795   -17.97986 1.000 25.99276 ? 1099 HOH A O   1 
HETATM 4341 O O   A HOH C 3 .   ? 41.692    -16.870   -7.036    0.634 16.16931 ? 1100 HOH A O   1 
HETATM 4342 O O   B HOH C 3 .   ? 42.711    -15.939   -7.083    0.366 16.85247 ? 1100 HOH A O   1 
HETATM 4343 O O   . HOH C 3 .   ? -2.86684  -19.43326 -16.05900 1.000 17.18525 ? 1101 HOH A O   1 
HETATM 4344 O O   . HOH C 3 .   ? 21.76555  6.93798   1.47604   1.000 27.10205 ? 1102 HOH A O   1 
HETATM 4345 O O   . HOH C 3 .   ? 25.739    7.733     -42.237   1.000 20.74929 ? 1103 HOH A O   1 
HETATM 4346 O O   . HOH C 3 .   ? 37.29423  -12.63565 -30.54994 1.000 24.22210 ? 1104 HOH A O   1 
HETATM 4347 O O   . HOH C 3 .   ? 7.86155   -23.91064 -20.66798 1.000 22.31558 ? 1105 HOH A O   1 
HETATM 4348 O O   . HOH C 3 .   ? -1.157    9.085     -29.123   1.000 17.34021 ? 1106 HOH A O   1 
HETATM 4349 O O   . HOH C 3 .   ? 10.11323  -17.76262 -33.32239 1.000 23.66333 ? 1107 HOH A O   1 
HETATM 4350 O O   . HOH C 3 .   ? 14.150    -35.235   -21.813   1.000 17.47670 ? 1108 HOH A O   1 
HETATM 4351 O O   . HOH C 3 .   ? 1.817     -21.382   -25.363   1.000 26.75491 ? 1109 HOH A O   1 
HETATM 4352 O O   . HOH C 3 .   ? 27.82860  -25.73762 1.81943   1.000 24.60844 ? 1110 HOH A O   1 
HETATM 4353 O O   . HOH C 3 .   ? -0.453    5.094     -30.054   1.000 26.19304 ? 1111 HOH A O   1 
HETATM 4354 O O   . HOH C 3 .   ? 12.08763  -20.21912 -31.55565 1.000 21.35731 ? 1112 HOH A O   1 
HETATM 4355 O O   . HOH C 3 .   ? -3.25271  -7.01813  -11.67952 1.000 23.82396 ? 1113 HOH A O   1 
HETATM 4356 O O   . HOH C 3 .   ? 36.59887  -2.68577  -5.64702  1.000 22.00101 ? 1114 HOH A O   1 
HETATM 4357 O O   . HOH C 3 .   ? 15.537    -33.692   -24.225   1.000 27.94173 ? 1115 HOH A O   1 
HETATM 4358 O O   . HOH C 3 .   ? -16.32644 -8.69962  -31.64388 1.000 33.86102 ? 1116 HOH A O   1 
HETATM 4359 O O   . HOH C 3 .   ? 8.930     -29.259   3.655     1.000 16.12565 ? 1117 HOH A O   1 
HETATM 4360 O O   . HOH C 3 .   ? -1.64740  -20.21359 -11.58201 1.000 27.01519 ? 1118 HOH A O   1 
HETATM 4361 O O   . HOH C 3 .   ? 5.86883   -20.38160 -25.15653 1.000 18.66177 ? 1119 HOH A O   1 
HETATM 4362 O O   . HOH C 3 .   ? 34.31280  -5.31917  -33.86746 1.000 24.89965 ? 1120 HOH A O   1 
HETATM 4363 O O   . HOH C 3 .   ? 34.53248  -17.97028 -30.91864 1.000 23.55484 ? 1121 HOH A O   1 
HETATM 4364 O O   . HOH C 3 .   ? 5.24917   -6.34378  -1.55998  1.000 34.19487 ? 1122 HOH A O   1 
HETATM 4365 O O   . HOH C 3 .   ? 37.77195  0.80469   -14.81112 1.000 31.48591 ? 1123 HOH A O   1 
HETATM 4366 O O   . HOH C 3 .   ? 23.66360  1.64533   -39.33170 1.000 23.95756 ? 1124 HOH A O   1 
HETATM 4367 O O   . HOH C 3 .   ? 37.84215  -0.37382  -5.08985  1.000 29.15229 ? 1125 HOH A O   1 
HETATM 4368 O O   . HOH C 3 .   ? 5.14392   -24.32404 -24.32712 1.000 30.98728 ? 1126 HOH A O   1 
HETATM 4369 O O   . HOH C 3 .   ? 11.17156  -6.85901  5.95364   1.000 20.89084 ? 1127 HOH A O   1 
HETATM 4370 O O   . HOH C 3 .   ? -2.89511  9.23351   -15.65532 1.000 30.19608 ? 1128 HOH A O   1 
HETATM 4371 O O   . HOH C 3 .   ? -6.583    15.481    -8.397    1.000 29.59817 ? 1129 HOH A O   1 
HETATM 4372 O O   . HOH C 3 .   ? -2.06666  11.61964  -16.58464 1.000 32.55379 ? 1130 HOH A O   1 
HETATM 4373 O O   . HOH C 3 .   ? 10.95306  -19.81361 -33.91006 1.000 31.76166 ? 1131 HOH A O   1 
HETATM 4374 O O   . HOH C 3 .   ? -4.62002  8.52350   -17.55927 1.000 33.56033 ? 1132 HOH A O   1 
# 
