data_8WZ9
# 
_entry.id   8WZ9 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8WZ9         pdb_00008wz9 10.2210/pdb8wz9/pdb 
WWPDB D_1300042129 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.journal_volume'          
7  2 'Structure model' '_citation.page_first'              
8  2 'Structure model' '_citation.page_last'               
9  2 'Structure model' '_citation.pdbx_database_id_DOI'    
10 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 2 'Structure model' '_citation.title'                   
12 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8WZ9 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 hhge@ahu.edu.cn Honghua Ge ? 'principal investigator/group leader' 0000-0001-7176-6853 
4 jmma@ahu.edu.cn Jinming Ma ? 'principal investigator/group leader' 0000-0002-3199-9860 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Gao, Y.S.'  1 0009-0005-6639-4713 
'Xie, R.'    2 ?                   
'Chen, Y.N.' 3 ?                   
'Ma, J.M.'   4 ?                   
'Ge, H.H.'   5 0000-0001-7176-6853 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            270 
_citation.language                  ? 
_citation.page_first                132289 
_citation.page_last                 132289 
_citation.title                     
'Structural basis for substrate recognition by a S-adenosylhomocysteine hydrolase Lpg2021 from Legionella pneumophila.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2024.132289 
_citation.pdbx_database_id_PubMed   38735607 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gao, Y.'  1  ? 
primary 'Xie, R.'  2  ? 
primary 'Chen, Y.' 3  ? 
primary 'Yang, B.' 4  ? 
primary 'Wang, M.' 5  ? 
primary 'Hua, L.'  6  ? 
primary 'Wang, X.' 7  ? 
primary 'Wang, W.' 8  ? 
primary 'Wang, N.' 9  ? 
primary 'Ge, H.'   10 ? 
primary 'Ma, J.'   11 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Adenosylhomocysteinase            48372.074 1   ? ? ? ? 
2 non-polymer syn NICOTINAMIDE-ADENINE-DINUCLEOTIDE 663.425   1   ? ? ? ? 
3 non-polymer syn ADENINE                           135.127   1   ? ? ? ? 
4 non-polymer syn 'SULFATE ION'                     96.063    2   ? ? ? ? 
5 water       nat water                             18.015    508 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGHHHHHHHHQDYKVAEISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVALGAEV
RWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQVVHQKHPKLLTAIKGV
SEETTTGVARLYEMAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCAQALR
GQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQSLKQ
YQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLDEKVA
RLHLGRIGAKLTQLSNEQADYIGVDKNGPYKPDHYRY
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGHHHHHHHHQDYKVAEISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVALGAEV
RWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQVVHQKHPKLLTAIKGV
SEETTTGVARLYEMAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCAQALR
GQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQSLKQ
YQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLDEKVA
RLHLGRIGAKLTQLSNEQADYIGVDKNGPYKPDHYRY
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 NICOTINAMIDE-ADENINE-DINUCLEOTIDE NAD 
3 ADENINE                           ADE 
4 'SULFATE ION'                     SO4 
5 water                             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  GLN n 
1 12  ASP n 
1 13  TYR n 
1 14  LYS n 
1 15  VAL n 
1 16  ALA n 
1 17  GLU n 
1 18  ILE n 
1 19  SER n 
1 20  LEU n 
1 21  ALA n 
1 22  ASP n 
1 23  TRP n 
1 24  GLY n 
1 25  ARG n 
1 26  LYS n 
1 27  GLU n 
1 28  ILE n 
1 29  ALA n 
1 30  ILE n 
1 31  ALA n 
1 32  GLU n 
1 33  THR n 
1 34  GLU n 
1 35  MET n 
1 36  PRO n 
1 37  GLY n 
1 38  LEU n 
1 39  MET n 
1 40  ALA n 
1 41  LEU n 
1 42  ARG n 
1 43  GLU n 
1 44  GLU n 
1 45  PHE n 
1 46  SER n 
1 47  ALA n 
1 48  LYS n 
1 49  LYS n 
1 50  PRO n 
1 51  LEU n 
1 52  GLN n 
1 53  GLY n 
1 54  ALA n 
1 55  ARG n 
1 56  ILE n 
1 57  ALA n 
1 58  GLY n 
1 59  CYS n 
1 60  LEU n 
1 61  HIS n 
1 62  MET n 
1 63  THR n 
1 64  ILE n 
1 65  GLN n 
1 66  THR n 
1 67  ALA n 
1 68  VAL n 
1 69  LEU n 
1 70  ILE n 
1 71  GLU n 
1 72  THR n 
1 73  LEU n 
1 74  VAL n 
1 75  ALA n 
1 76  LEU n 
1 77  GLY n 
1 78  ALA n 
1 79  GLU n 
1 80  VAL n 
1 81  ARG n 
1 82  TRP n 
1 83  SER n 
1 84  SER n 
1 85  CYS n 
1 86  ASN n 
1 87  ILE n 
1 88  PHE n 
1 89  SER n 
1 90  THR n 
1 91  GLN n 
1 92  ASP n 
1 93  HIS n 
1 94  ALA n 
1 95  ALA n 
1 96  SER n 
1 97  ALA n 
1 98  ILE n 
1 99  ALA n 
1 100 ALA n 
1 101 LYS n 
1 102 GLY n 
1 103 ILE n 
1 104 PRO n 
1 105 VAL n 
1 106 PHE n 
1 107 ALA n 
1 108 TRP n 
1 109 LYS n 
1 110 GLY n 
1 111 GLU n 
1 112 THR n 
1 113 GLU n 
1 114 GLU n 
1 115 GLU n 
1 116 TYR n 
1 117 TRP n 
1 118 TRP n 
1 119 CYS n 
1 120 VAL n 
1 121 GLU n 
1 122 GLN n 
1 123 THR n 
1 124 LEU n 
1 125 SER n 
1 126 GLY n 
1 127 PRO n 
1 128 ASN n 
1 129 GLY n 
1 130 TRP n 
1 131 THR n 
1 132 PRO n 
1 133 ASN n 
1 134 LEU n 
1 135 LEU n 
1 136 LEU n 
1 137 ASP n 
1 138 ASP n 
1 139 GLY n 
1 140 GLY n 
1 141 ASP n 
1 142 LEU n 
1 143 THR n 
1 144 GLN n 
1 145 VAL n 
1 146 VAL n 
1 147 HIS n 
1 148 GLN n 
1 149 LYS n 
1 150 HIS n 
1 151 PRO n 
1 152 LYS n 
1 153 LEU n 
1 154 LEU n 
1 155 THR n 
1 156 ALA n 
1 157 ILE n 
1 158 LYS n 
1 159 GLY n 
1 160 VAL n 
1 161 SER n 
1 162 GLU n 
1 163 GLU n 
1 164 THR n 
1 165 THR n 
1 166 THR n 
1 167 GLY n 
1 168 VAL n 
1 169 ALA n 
1 170 ARG n 
1 171 LEU n 
1 172 TYR n 
1 173 GLU n 
1 174 MET n 
1 175 ALA n 
1 176 LYS n 
1 177 HIS n 
1 178 GLY n 
1 179 GLN n 
1 180 LEU n 
1 181 LYS n 
1 182 ILE n 
1 183 PRO n 
1 184 ALA n 
1 185 ILE n 
1 186 ASN n 
1 187 VAL n 
1 188 ASN n 
1 189 ASN n 
1 190 ALA n 
1 191 VAL n 
1 192 THR n 
1 193 LYS n 
1 194 SER n 
1 195 LYS n 
1 196 PHE n 
1 197 ASP n 
1 198 ASN n 
1 199 LEU n 
1 200 TYR n 
1 201 GLY n 
1 202 CYS n 
1 203 ARG n 
1 204 GLU n 
1 205 SER n 
1 206 LEU n 
1 207 LEU n 
1 208 ASP n 
1 209 GLY n 
1 210 LEU n 
1 211 LYS n 
1 212 ARG n 
1 213 ALA n 
1 214 THR n 
1 215 ASP n 
1 216 VAL n 
1 217 MET n 
1 218 ILE n 
1 219 ALA n 
1 220 GLY n 
1 221 LYS n 
1 222 VAL n 
1 223 ALA n 
1 224 LEU n 
1 225 ILE n 
1 226 LEU n 
1 227 GLY n 
1 228 TYR n 
1 229 GLY n 
1 230 ASP n 
1 231 VAL n 
1 232 GLY n 
1 233 LYS n 
1 234 GLY n 
1 235 CYS n 
1 236 ALA n 
1 237 GLN n 
1 238 ALA n 
1 239 LEU n 
1 240 ARG n 
1 241 GLY n 
1 242 GLN n 
1 243 GLY n 
1 244 ALA n 
1 245 THR n 
1 246 VAL n 
1 247 LEU n 
1 248 VAL n 
1 249 ALA n 
1 250 GLU n 
1 251 ILE n 
1 252 ASP n 
1 253 PRO n 
1 254 ILE n 
1 255 CYS n 
1 256 ALA n 
1 257 LEU n 
1 258 GLN n 
1 259 ALA n 
1 260 ALA n 
1 261 MET n 
1 262 GLU n 
1 263 GLY n 
1 264 TYR n 
1 265 ARG n 
1 266 VAL n 
1 267 VAL n 
1 268 THR n 
1 269 LEU n 
1 270 ASP n 
1 271 ASP n 
1 272 VAL n 
1 273 ALA n 
1 274 GLU n 
1 275 GLN n 
1 276 VAL n 
1 277 ASP n 
1 278 ILE n 
1 279 VAL n 
1 280 VAL n 
1 281 THR n 
1 282 ALA n 
1 283 THR n 
1 284 GLY n 
1 285 ASN n 
1 286 TYR n 
1 287 HIS n 
1 288 VAL n 
1 289 VAL n 
1 290 THR n 
1 291 HIS n 
1 292 ASP n 
1 293 HIS n 
1 294 MET n 
1 295 LYS n 
1 296 ARG n 
1 297 MET n 
1 298 ARG n 
1 299 ASN n 
1 300 GLN n 
1 301 ALA n 
1 302 ILE n 
1 303 LEU n 
1 304 CYS n 
1 305 ASN n 
1 306 ILE n 
1 307 GLY n 
1 308 HIS n 
1 309 PHE n 
1 310 ASP n 
1 311 SER n 
1 312 GLU n 
1 313 ILE n 
1 314 ASP n 
1 315 ILE n 
1 316 GLN n 
1 317 SER n 
1 318 LEU n 
1 319 LYS n 
1 320 GLN n 
1 321 TYR n 
1 322 GLN n 
1 323 TRP n 
1 324 GLU n 
1 325 ASN n 
1 326 ILE n 
1 327 LYS n 
1 328 PRO n 
1 329 GLN n 
1 330 VAL n 
1 331 ASP n 
1 332 HIS n 
1 333 VAL n 
1 334 ILE n 
1 335 PHE n 
1 336 PRO n 
1 337 ASP n 
1 338 GLY n 
1 339 LYS n 
1 340 ARG n 
1 341 ILE n 
1 342 ILE n 
1 343 ILE n 
1 344 LEU n 
1 345 ALA n 
1 346 GLU n 
1 347 GLY n 
1 348 ARG n 
1 349 LEU n 
1 350 VAL n 
1 351 ASN n 
1 352 LEU n 
1 353 GLY n 
1 354 CYS n 
1 355 ALA n 
1 356 THR n 
1 357 GLY n 
1 358 HIS n 
1 359 PRO n 
1 360 SER n 
1 361 PHE n 
1 362 VAL n 
1 363 MET n 
1 364 SER n 
1 365 ALA n 
1 366 SER n 
1 367 PHE n 
1 368 THR n 
1 369 ASN n 
1 370 GLN n 
1 371 VAL n 
1 372 LEU n 
1 373 ALA n 
1 374 GLN n 
1 375 ILE n 
1 376 GLU n 
1 377 LEU n 
1 378 PHE n 
1 379 GLN n 
1 380 ASN n 
1 381 SER n 
1 382 SER n 
1 383 GLN n 
1 384 TYR n 
1 385 GLN n 
1 386 ASN n 
1 387 GLN n 
1 388 VAL n 
1 389 TYR n 
1 390 VAL n 
1 391 LEU n 
1 392 PRO n 
1 393 LYS n 
1 394 VAL n 
1 395 LEU n 
1 396 ASP n 
1 397 GLU n 
1 398 LYS n 
1 399 VAL n 
1 400 ALA n 
1 401 ARG n 
1 402 LEU n 
1 403 HIS n 
1 404 LEU n 
1 405 GLY n 
1 406 ARG n 
1 407 ILE n 
1 408 GLY n 
1 409 ALA n 
1 410 LYS n 
1 411 LEU n 
1 412 THR n 
1 413 GLN n 
1 414 LEU n 
1 415 SER n 
1 416 ASN n 
1 417 GLU n 
1 418 GLN n 
1 419 ALA n 
1 420 ASP n 
1 421 TYR n 
1 422 ILE n 
1 423 GLY n 
1 424 VAL n 
1 425 ASP n 
1 426 LYS n 
1 427 ASN n 
1 428 GLY n 
1 429 PRO n 
1 430 TYR n 
1 431 LYS n 
1 432 PRO n 
1 433 ASP n 
1 434 HIS n 
1 435 TYR n 
1 436 ARG n 
1 437 TYR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   437 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ahcY 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Legionella pneumophila' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     446 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'Rosetta 2(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ADE non-polymer         . ADENINE                           ? 'C5 H5 N5'          135.127 
ALA 'L-peptide linking' y ALANINE                           ? 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                          ? 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                        ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                   ? 'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE                          ? 'C3 H7 N O2 S'      121.158 
GLN 'L-peptide linking' y GLUTAMINE                         ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                   ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                           ? 'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                         ? 'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                             ? 'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                        ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                           ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                            ? 'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                        ? 'C5 H11 N O2 S'     149.211 
NAD non-polymer         . NICOTINAMIDE-ADENINE-DINUCLEOTIDE ? 'C21 H27 N7 O14 P2' 663.425 
PHE 'L-peptide linking' y PHENYLALANINE                     ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                           ? 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                            ? 'C3 H7 N O3'        105.093 
SO4 non-polymer         . 'SULFATE ION'                     ? 'O4 S -2'           96.063  
THR 'L-peptide linking' y THREONINE                         ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                        ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                          ? 'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                            ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   5   ?   ?   ?   A . n 
A 1 2   GLY 2   6   ?   ?   ?   A . n 
A 1 3   HIS 3   7   ?   ?   ?   A . n 
A 1 4   HIS 4   8   ?   ?   ?   A . n 
A 1 5   HIS 5   9   ?   ?   ?   A . n 
A 1 6   HIS 6   10  ?   ?   ?   A . n 
A 1 7   HIS 7   11  ?   ?   ?   A . n 
A 1 8   HIS 8   12  ?   ?   ?   A . n 
A 1 9   HIS 9   13  ?   ?   ?   A . n 
A 1 10  HIS 10  14  ?   ?   ?   A . n 
A 1 11  GLN 11  15  15  GLN GLN A . n 
A 1 12  ASP 12  16  16  ASP ASP A . n 
A 1 13  TYR 13  17  17  TYR TYR A . n 
A 1 14  LYS 14  18  18  LYS LYS A . n 
A 1 15  VAL 15  19  19  VAL VAL A . n 
A 1 16  ALA 16  20  20  ALA ALA A . n 
A 1 17  GLU 17  21  21  GLU GLU A . n 
A 1 18  ILE 18  22  22  ILE ILE A . n 
A 1 19  SER 19  23  23  SER SER A . n 
A 1 20  LEU 20  24  24  LEU LEU A . n 
A 1 21  ALA 21  25  25  ALA ALA A . n 
A 1 22  ASP 22  26  26  ASP ASP A . n 
A 1 23  TRP 23  27  27  TRP TRP A . n 
A 1 24  GLY 24  28  28  GLY GLY A . n 
A 1 25  ARG 25  29  29  ARG ARG A . n 
A 1 26  LYS 26  30  30  LYS LYS A . n 
A 1 27  GLU 27  31  31  GLU GLU A . n 
A 1 28  ILE 28  32  32  ILE ILE A . n 
A 1 29  ALA 29  33  33  ALA ALA A . n 
A 1 30  ILE 30  34  34  ILE ILE A . n 
A 1 31  ALA 31  35  35  ALA ALA A . n 
A 1 32  GLU 32  36  36  GLU GLU A . n 
A 1 33  THR 33  37  37  THR THR A . n 
A 1 34  GLU 34  38  38  GLU GLU A . n 
A 1 35  MET 35  39  39  MET MET A . n 
A 1 36  PRO 36  40  40  PRO PRO A . n 
A 1 37  GLY 37  41  41  GLY GLY A . n 
A 1 38  LEU 38  42  42  LEU LEU A . n 
A 1 39  MET 39  43  43  MET MET A . n 
A 1 40  ALA 40  44  44  ALA ALA A . n 
A 1 41  LEU 41  45  45  LEU LEU A . n 
A 1 42  ARG 42  46  46  ARG ARG A . n 
A 1 43  GLU 43  47  47  GLU GLU A . n 
A 1 44  GLU 44  48  48  GLU GLU A . n 
A 1 45  PHE 45  49  49  PHE PHE A . n 
A 1 46  SER 46  50  50  SER SER A . n 
A 1 47  ALA 47  51  51  ALA ALA A . n 
A 1 48  LYS 48  52  52  LYS LYS A . n 
A 1 49  LYS 49  53  53  LYS LYS A . n 
A 1 50  PRO 50  54  54  PRO PRO A . n 
A 1 51  LEU 51  55  55  LEU LEU A . n 
A 1 52  GLN 52  56  56  GLN GLN A . n 
A 1 53  GLY 53  57  57  GLY GLY A . n 
A 1 54  ALA 54  58  58  ALA ALA A . n 
A 1 55  ARG 55  59  59  ARG ARG A . n 
A 1 56  ILE 56  60  60  ILE ILE A . n 
A 1 57  ALA 57  61  61  ALA ALA A . n 
A 1 58  GLY 58  62  62  GLY GLY A . n 
A 1 59  CYS 59  63  63  CYS CYS A . n 
A 1 60  LEU 60  64  64  LEU LEU A . n 
A 1 61  HIS 61  65  65  HIS HIS A . n 
A 1 62  MET 62  66  66  MET MET A . n 
A 1 63  THR 63  67  67  THR THR A . n 
A 1 64  ILE 64  68  68  ILE ILE A . n 
A 1 65  GLN 65  69  69  GLN GLN A . n 
A 1 66  THR 66  70  70  THR THR A . n 
A 1 67  ALA 67  71  71  ALA ALA A . n 
A 1 68  VAL 68  72  72  VAL VAL A . n 
A 1 69  LEU 69  73  73  LEU LEU A . n 
A 1 70  ILE 70  74  74  ILE ILE A . n 
A 1 71  GLU 71  75  75  GLU GLU A . n 
A 1 72  THR 72  76  76  THR THR A . n 
A 1 73  LEU 73  77  77  LEU LEU A . n 
A 1 74  VAL 74  78  78  VAL VAL A . n 
A 1 75  ALA 75  79  79  ALA ALA A . n 
A 1 76  LEU 76  80  80  LEU LEU A . n 
A 1 77  GLY 77  81  81  GLY GLY A . n 
A 1 78  ALA 78  82  82  ALA ALA A . n 
A 1 79  GLU 79  83  83  GLU GLU A . n 
A 1 80  VAL 80  84  84  VAL VAL A . n 
A 1 81  ARG 81  85  85  ARG ARG A . n 
A 1 82  TRP 82  86  86  TRP TRP A . n 
A 1 83  SER 83  87  87  SER SER A . n 
A 1 84  SER 84  88  88  SER SER A . n 
A 1 85  CYS 85  89  89  CYS CYS A . n 
A 1 86  ASN 86  90  90  ASN ASN A . n 
A 1 87  ILE 87  91  91  ILE ILE A . n 
A 1 88  PHE 88  92  92  PHE PHE A . n 
A 1 89  SER 89  93  93  SER SER A . n 
A 1 90  THR 90  94  94  THR THR A . n 
A 1 91  GLN 91  95  95  GLN GLN A . n 
A 1 92  ASP 92  96  96  ASP ASP A . n 
A 1 93  HIS 93  97  97  HIS HIS A . n 
A 1 94  ALA 94  98  98  ALA ALA A . n 
A 1 95  ALA 95  99  99  ALA ALA A . n 
A 1 96  SER 96  100 100 SER SER A . n 
A 1 97  ALA 97  101 101 ALA ALA A . n 
A 1 98  ILE 98  102 102 ILE ILE A . n 
A 1 99  ALA 99  103 103 ALA ALA A . n 
A 1 100 ALA 100 104 104 ALA ALA A . n 
A 1 101 LYS 101 105 105 LYS LYS A . n 
A 1 102 GLY 102 106 106 GLY GLY A . n 
A 1 103 ILE 103 107 107 ILE ILE A . n 
A 1 104 PRO 104 108 108 PRO PRO A . n 
A 1 105 VAL 105 109 109 VAL VAL A . n 
A 1 106 PHE 106 110 110 PHE PHE A . n 
A 1 107 ALA 107 111 111 ALA ALA A . n 
A 1 108 TRP 108 112 112 TRP TRP A . n 
A 1 109 LYS 109 113 113 LYS LYS A . n 
A 1 110 GLY 110 114 114 GLY GLY A . n 
A 1 111 GLU 111 115 115 GLU GLU A . n 
A 1 112 THR 112 116 116 THR THR A . n 
A 1 113 GLU 113 117 117 GLU GLU A . n 
A 1 114 GLU 114 118 118 GLU GLU A . n 
A 1 115 GLU 115 119 119 GLU GLU A . n 
A 1 116 TYR 116 120 120 TYR TYR A . n 
A 1 117 TRP 117 121 121 TRP TRP A . n 
A 1 118 TRP 118 122 122 TRP TRP A . n 
A 1 119 CYS 119 123 123 CYS CYS A . n 
A 1 120 VAL 120 124 124 VAL VAL A . n 
A 1 121 GLU 121 125 125 GLU GLU A . n 
A 1 122 GLN 122 126 126 GLN GLN A . n 
A 1 123 THR 123 127 127 THR THR A . n 
A 1 124 LEU 124 128 128 LEU LEU A . n 
A 1 125 SER 125 129 129 SER SER A . n 
A 1 126 GLY 126 130 130 GLY GLY A . n 
A 1 127 PRO 127 131 131 PRO PRO A . n 
A 1 128 ASN 128 132 132 ASN ASN A . n 
A 1 129 GLY 129 133 133 GLY GLY A . n 
A 1 130 TRP 130 134 134 TRP TRP A . n 
A 1 131 THR 131 135 135 THR THR A . n 
A 1 132 PRO 132 136 136 PRO PRO A . n 
A 1 133 ASN 133 137 137 ASN ASN A . n 
A 1 134 LEU 134 138 138 LEU LEU A . n 
A 1 135 LEU 135 139 139 LEU LEU A . n 
A 1 136 LEU 136 140 140 LEU LEU A . n 
A 1 137 ASP 137 141 141 ASP ASP A . n 
A 1 138 ASP 138 142 142 ASP ASP A . n 
A 1 139 GLY 139 143 143 GLY GLY A . n 
A 1 140 GLY 140 144 144 GLY GLY A . n 
A 1 141 ASP 141 145 145 ASP ASP A . n 
A 1 142 LEU 142 146 146 LEU LEU A . n 
A 1 143 THR 143 147 147 THR THR A . n 
A 1 144 GLN 144 148 148 GLN GLN A . n 
A 1 145 VAL 145 149 149 VAL VAL A . n 
A 1 146 VAL 146 150 150 VAL VAL A . n 
A 1 147 HIS 147 151 151 HIS HIS A . n 
A 1 148 GLN 148 152 152 GLN GLN A . n 
A 1 149 LYS 149 153 153 LYS LYS A . n 
A 1 150 HIS 150 154 154 HIS HIS A . n 
A 1 151 PRO 151 155 155 PRO PRO A . n 
A 1 152 LYS 152 156 156 LYS LYS A . n 
A 1 153 LEU 153 157 157 LEU LEU A . n 
A 1 154 LEU 154 158 158 LEU LEU A . n 
A 1 155 THR 155 159 159 THR THR A . n 
A 1 156 ALA 156 160 160 ALA ALA A . n 
A 1 157 ILE 157 161 161 ILE ILE A . n 
A 1 158 LYS 158 162 162 LYS LYS A . n 
A 1 159 GLY 159 163 163 GLY GLY A . n 
A 1 160 VAL 160 164 164 VAL VAL A . n 
A 1 161 SER 161 165 165 SER SER A . n 
A 1 162 GLU 162 166 166 GLU GLU A . n 
A 1 163 GLU 163 167 167 GLU GLU A . n 
A 1 164 THR 164 168 168 THR THR A . n 
A 1 165 THR 165 169 169 THR THR A . n 
A 1 166 THR 166 170 170 THR THR A . n 
A 1 167 GLY 167 171 171 GLY GLY A . n 
A 1 168 VAL 168 172 172 VAL VAL A . n 
A 1 169 ALA 169 173 173 ALA ALA A . n 
A 1 170 ARG 170 174 174 ARG ARG A . n 
A 1 171 LEU 171 175 175 LEU LEU A . n 
A 1 172 TYR 172 176 176 TYR TYR A . n 
A 1 173 GLU 173 177 177 GLU GLU A . n 
A 1 174 MET 174 178 178 MET MET A . n 
A 1 175 ALA 175 179 179 ALA ALA A . n 
A 1 176 LYS 176 180 180 LYS LYS A . n 
A 1 177 HIS 177 181 181 HIS HIS A . n 
A 1 178 GLY 178 182 182 GLY GLY A . n 
A 1 179 GLN 179 183 183 GLN GLN A . n 
A 1 180 LEU 180 184 184 LEU LEU A . n 
A 1 181 LYS 181 185 185 LYS LYS A . n 
A 1 182 ILE 182 186 186 ILE ILE A . n 
A 1 183 PRO 183 187 187 PRO PRO A . n 
A 1 184 ALA 184 188 188 ALA ALA A . n 
A 1 185 ILE 185 189 189 ILE ILE A . n 
A 1 186 ASN 186 190 190 ASN ASN A . n 
A 1 187 VAL 187 191 191 VAL VAL A . n 
A 1 188 ASN 188 192 192 ASN ASN A . n 
A 1 189 ASN 189 193 193 ASN ASN A . n 
A 1 190 ALA 190 194 194 ALA ALA A . n 
A 1 191 VAL 191 195 195 VAL VAL A . n 
A 1 192 THR 192 196 196 THR THR A . n 
A 1 193 LYS 193 197 197 LYS LYS A . n 
A 1 194 SER 194 198 198 SER SER A . n 
A 1 195 LYS 195 199 199 LYS LYS A . n 
A 1 196 PHE 196 200 200 PHE PHE A . n 
A 1 197 ASP 197 201 201 ASP ASP A . n 
A 1 198 ASN 198 202 202 ASN ASN A . n 
A 1 199 LEU 199 203 203 LEU LEU A . n 
A 1 200 TYR 200 204 204 TYR TYR A . n 
A 1 201 GLY 201 205 205 GLY GLY A . n 
A 1 202 CYS 202 206 206 CYS CYS A . n 
A 1 203 ARG 203 207 207 ARG ARG A . n 
A 1 204 GLU 204 208 208 GLU GLU A . n 
A 1 205 SER 205 209 209 SER SER A . n 
A 1 206 LEU 206 210 210 LEU LEU A . n 
A 1 207 LEU 207 211 211 LEU LEU A . n 
A 1 208 ASP 208 212 212 ASP ASP A . n 
A 1 209 GLY 209 213 213 GLY GLY A . n 
A 1 210 LEU 210 214 214 LEU LEU A . n 
A 1 211 LYS 211 215 215 LYS LYS A . n 
A 1 212 ARG 212 216 216 ARG ARG A . n 
A 1 213 ALA 213 217 217 ALA ALA A . n 
A 1 214 THR 214 218 218 THR THR A . n 
A 1 215 ASP 215 219 219 ASP ASP A . n 
A 1 216 VAL 216 220 220 VAL VAL A . n 
A 1 217 MET 217 221 221 MET MET A . n 
A 1 218 ILE 218 222 222 ILE ILE A . n 
A 1 219 ALA 219 223 223 ALA ALA A . n 
A 1 220 GLY 220 224 224 GLY GLY A . n 
A 1 221 LYS 221 225 225 LYS LYS A . n 
A 1 222 VAL 222 226 226 VAL VAL A . n 
A 1 223 ALA 223 227 227 ALA ALA A . n 
A 1 224 LEU 224 228 228 LEU LEU A . n 
A 1 225 ILE 225 229 229 ILE ILE A . n 
A 1 226 LEU 226 230 230 LEU LEU A . n 
A 1 227 GLY 227 231 231 GLY GLY A . n 
A 1 228 TYR 228 232 232 TYR TYR A . n 
A 1 229 GLY 229 233 233 GLY GLY A . n 
A 1 230 ASP 230 234 234 ASP ASP A . n 
A 1 231 VAL 231 235 235 VAL VAL A . n 
A 1 232 GLY 232 236 236 GLY GLY A . n 
A 1 233 LYS 233 237 237 LYS LYS A . n 
A 1 234 GLY 234 238 238 GLY GLY A . n 
A 1 235 CYS 235 239 239 CYS CYS A . n 
A 1 236 ALA 236 240 240 ALA ALA A . n 
A 1 237 GLN 237 241 241 GLN GLN A . n 
A 1 238 ALA 238 242 242 ALA ALA A . n 
A 1 239 LEU 239 243 243 LEU LEU A . n 
A 1 240 ARG 240 244 244 ARG ARG A . n 
A 1 241 GLY 241 245 245 GLY GLY A . n 
A 1 242 GLN 242 246 246 GLN GLN A . n 
A 1 243 GLY 243 247 247 GLY GLY A . n 
A 1 244 ALA 244 248 248 ALA ALA A . n 
A 1 245 THR 245 249 249 THR THR A . n 
A 1 246 VAL 246 250 250 VAL VAL A . n 
A 1 247 LEU 247 251 251 LEU LEU A . n 
A 1 248 VAL 248 252 252 VAL VAL A . n 
A 1 249 ALA 249 253 253 ALA ALA A . n 
A 1 250 GLU 250 254 254 GLU GLU A . n 
A 1 251 ILE 251 255 255 ILE ILE A . n 
A 1 252 ASP 252 256 256 ASP ASP A . n 
A 1 253 PRO 253 257 257 PRO PRO A . n 
A 1 254 ILE 254 258 258 ILE ILE A . n 
A 1 255 CYS 255 259 259 CYS CYS A . n 
A 1 256 ALA 256 260 260 ALA ALA A . n 
A 1 257 LEU 257 261 261 LEU LEU A . n 
A 1 258 GLN 258 262 262 GLN GLN A . n 
A 1 259 ALA 259 263 263 ALA ALA A . n 
A 1 260 ALA 260 264 264 ALA ALA A . n 
A 1 261 MET 261 265 265 MET MET A . n 
A 1 262 GLU 262 266 266 GLU GLU A . n 
A 1 263 GLY 263 267 267 GLY GLY A . n 
A 1 264 TYR 264 268 268 TYR TYR A . n 
A 1 265 ARG 265 269 269 ARG ARG A . n 
A 1 266 VAL 266 270 270 VAL VAL A . n 
A 1 267 VAL 267 271 271 VAL VAL A . n 
A 1 268 THR 268 272 272 THR THR A . n 
A 1 269 LEU 269 273 273 LEU LEU A . n 
A 1 270 ASP 270 274 274 ASP ASP A . n 
A 1 271 ASP 271 275 275 ASP ASP A . n 
A 1 272 VAL 272 276 276 VAL VAL A . n 
A 1 273 ALA 273 277 277 ALA ALA A . n 
A 1 274 GLU 274 278 278 GLU GLU A . n 
A 1 275 GLN 275 279 279 GLN GLN A . n 
A 1 276 VAL 276 280 280 VAL VAL A . n 
A 1 277 ASP 277 281 281 ASP ASP A . n 
A 1 278 ILE 278 282 282 ILE ILE A . n 
A 1 279 VAL 279 283 283 VAL VAL A . n 
A 1 280 VAL 280 284 284 VAL VAL A . n 
A 1 281 THR 281 285 285 THR THR A . n 
A 1 282 ALA 282 286 286 ALA ALA A . n 
A 1 283 THR 283 287 287 THR THR A . n 
A 1 284 GLY 284 288 288 GLY GLY A . n 
A 1 285 ASN 285 289 289 ASN ASN A . n 
A 1 286 TYR 286 290 290 TYR TYR A . n 
A 1 287 HIS 287 291 291 HIS HIS A . n 
A 1 288 VAL 288 292 292 VAL VAL A . n 
A 1 289 VAL 289 293 293 VAL VAL A . n 
A 1 290 THR 290 294 294 THR THR A . n 
A 1 291 HIS 291 295 295 HIS HIS A . n 
A 1 292 ASP 292 296 296 ASP ASP A . n 
A 1 293 HIS 293 297 297 HIS HIS A . n 
A 1 294 MET 294 298 298 MET MET A . n 
A 1 295 LYS 295 299 299 LYS LYS A . n 
A 1 296 ARG 296 300 300 ARG ARG A . n 
A 1 297 MET 297 301 301 MET MET A . n 
A 1 298 ARG 298 302 302 ARG ARG A . n 
A 1 299 ASN 299 303 303 ASN ASN A . n 
A 1 300 GLN 300 304 304 GLN GLN A . n 
A 1 301 ALA 301 305 305 ALA ALA A . n 
A 1 302 ILE 302 306 306 ILE ILE A . n 
A 1 303 LEU 303 307 307 LEU LEU A . n 
A 1 304 CYS 304 308 308 CYS CYS A . n 
A 1 305 ASN 305 309 309 ASN ASN A . n 
A 1 306 ILE 306 310 310 ILE ILE A . n 
A 1 307 GLY 307 311 311 GLY GLY A . n 
A 1 308 HIS 308 312 312 HIS HIS A . n 
A 1 309 PHE 309 313 313 PHE PHE A . n 
A 1 310 ASP 310 314 314 ASP ASP A . n 
A 1 311 SER 311 315 315 SER SER A . n 
A 1 312 GLU 312 316 316 GLU GLU A . n 
A 1 313 ILE 313 317 317 ILE ILE A . n 
A 1 314 ASP 314 318 318 ASP ASP A . n 
A 1 315 ILE 315 319 319 ILE ILE A . n 
A 1 316 GLN 316 320 320 GLN GLN A . n 
A 1 317 SER 317 321 321 SER SER A . n 
A 1 318 LEU 318 322 322 LEU LEU A . n 
A 1 319 LYS 319 323 323 LYS LYS A . n 
A 1 320 GLN 320 324 324 GLN GLN A . n 
A 1 321 TYR 321 325 325 TYR TYR A . n 
A 1 322 GLN 322 326 326 GLN GLN A . n 
A 1 323 TRP 323 327 327 TRP TRP A . n 
A 1 324 GLU 324 328 328 GLU GLU A . n 
A 1 325 ASN 325 329 329 ASN ASN A . n 
A 1 326 ILE 326 330 330 ILE ILE A . n 
A 1 327 LYS 327 331 331 LYS LYS A . n 
A 1 328 PRO 328 332 332 PRO PRO A . n 
A 1 329 GLN 329 333 333 GLN GLN A . n 
A 1 330 VAL 330 334 334 VAL VAL A . n 
A 1 331 ASP 331 335 335 ASP ASP A . n 
A 1 332 HIS 332 336 336 HIS HIS A . n 
A 1 333 VAL 333 337 337 VAL VAL A . n 
A 1 334 ILE 334 338 338 ILE ILE A . n 
A 1 335 PHE 335 339 339 PHE PHE A . n 
A 1 336 PRO 336 340 340 PRO PRO A . n 
A 1 337 ASP 337 341 341 ASP ASP A . n 
A 1 338 GLY 338 342 342 GLY GLY A . n 
A 1 339 LYS 339 343 343 LYS LYS A . n 
A 1 340 ARG 340 344 344 ARG ARG A . n 
A 1 341 ILE 341 345 345 ILE ILE A . n 
A 1 342 ILE 342 346 346 ILE ILE A . n 
A 1 343 ILE 343 347 347 ILE ILE A . n 
A 1 344 LEU 344 348 348 LEU LEU A . n 
A 1 345 ALA 345 349 349 ALA ALA A . n 
A 1 346 GLU 346 350 350 GLU GLU A . n 
A 1 347 GLY 347 351 351 GLY GLY A . n 
A 1 348 ARG 348 352 352 ARG ARG A . n 
A 1 349 LEU 349 353 353 LEU LEU A . n 
A 1 350 VAL 350 354 354 VAL VAL A . n 
A 1 351 ASN 351 355 355 ASN ASN A . n 
A 1 352 LEU 352 356 356 LEU LEU A . n 
A 1 353 GLY 353 357 357 GLY GLY A . n 
A 1 354 CYS 354 358 358 CYS CYS A . n 
A 1 355 ALA 355 359 359 ALA ALA A . n 
A 1 356 THR 356 360 360 THR THR A . n 
A 1 357 GLY 357 361 361 GLY GLY A . n 
A 1 358 HIS 358 362 362 HIS HIS A . n 
A 1 359 PRO 359 363 363 PRO PRO A . n 
A 1 360 SER 360 364 364 SER SER A . n 
A 1 361 PHE 361 365 365 PHE PHE A . n 
A 1 362 VAL 362 366 366 VAL VAL A . n 
A 1 363 MET 363 367 367 MET MET A . n 
A 1 364 SER 364 368 368 SER SER A . n 
A 1 365 ALA 365 369 369 ALA ALA A . n 
A 1 366 SER 366 370 370 SER SER A . n 
A 1 367 PHE 367 371 371 PHE PHE A . n 
A 1 368 THR 368 372 372 THR THR A . n 
A 1 369 ASN 369 373 373 ASN ASN A . n 
A 1 370 GLN 370 374 374 GLN GLN A . n 
A 1 371 VAL 371 375 375 VAL VAL A . n 
A 1 372 LEU 372 376 376 LEU LEU A . n 
A 1 373 ALA 373 377 377 ALA ALA A . n 
A 1 374 GLN 374 378 378 GLN GLN A . n 
A 1 375 ILE 375 379 379 ILE ILE A . n 
A 1 376 GLU 376 380 380 GLU GLU A . n 
A 1 377 LEU 377 381 381 LEU LEU A . n 
A 1 378 PHE 378 382 382 PHE PHE A . n 
A 1 379 GLN 379 383 383 GLN GLN A . n 
A 1 380 ASN 380 384 384 ASN ASN A . n 
A 1 381 SER 381 385 385 SER SER A . n 
A 1 382 SER 382 386 386 SER SER A . n 
A 1 383 GLN 383 387 387 GLN GLN A . n 
A 1 384 TYR 384 388 388 TYR TYR A . n 
A 1 385 GLN 385 389 389 GLN GLN A . n 
A 1 386 ASN 386 390 390 ASN ASN A . n 
A 1 387 GLN 387 391 391 GLN GLN A . n 
A 1 388 VAL 388 392 392 VAL VAL A . n 
A 1 389 TYR 389 393 393 TYR TYR A . n 
A 1 390 VAL 390 394 394 VAL VAL A . n 
A 1 391 LEU 391 395 395 LEU LEU A . n 
A 1 392 PRO 392 396 396 PRO PRO A . n 
A 1 393 LYS 393 397 397 LYS LYS A . n 
A 1 394 VAL 394 398 398 VAL VAL A . n 
A 1 395 LEU 395 399 399 LEU LEU A . n 
A 1 396 ASP 396 400 400 ASP ASP A . n 
A 1 397 GLU 397 401 401 GLU GLU A . n 
A 1 398 LYS 398 402 402 LYS LYS A . n 
A 1 399 VAL 399 403 403 VAL VAL A . n 
A 1 400 ALA 400 404 404 ALA ALA A . n 
A 1 401 ARG 401 405 405 ARG ARG A . n 
A 1 402 LEU 402 406 406 LEU LEU A . n 
A 1 403 HIS 403 407 407 HIS HIS A . n 
A 1 404 LEU 404 408 408 LEU LEU A . n 
A 1 405 GLY 405 409 409 GLY GLY A . n 
A 1 406 ARG 406 410 410 ARG ARG A . n 
A 1 407 ILE 407 411 411 ILE ILE A . n 
A 1 408 GLY 408 412 412 GLY GLY A . n 
A 1 409 ALA 409 413 413 ALA ALA A . n 
A 1 410 LYS 410 414 414 LYS LYS A . n 
A 1 411 LEU 411 415 415 LEU LEU A . n 
A 1 412 THR 412 416 416 THR THR A . n 
A 1 413 GLN 413 417 417 GLN GLN A . n 
A 1 414 LEU 414 418 418 LEU LEU A . n 
A 1 415 SER 415 419 419 SER SER A . n 
A 1 416 ASN 416 420 420 ASN ASN A . n 
A 1 417 GLU 417 421 421 GLU GLU A . n 
A 1 418 GLN 418 422 422 GLN GLN A . n 
A 1 419 ALA 419 423 423 ALA ALA A . n 
A 1 420 ASP 420 424 424 ASP ASP A . n 
A 1 421 TYR 421 425 425 TYR TYR A . n 
A 1 422 ILE 422 426 426 ILE ILE A . n 
A 1 423 GLY 423 427 427 GLY GLY A . n 
A 1 424 VAL 424 428 428 VAL VAL A . n 
A 1 425 ASP 425 429 429 ASP ASP A . n 
A 1 426 LYS 426 430 430 LYS LYS A . n 
A 1 427 ASN 427 431 431 ASN ASN A . n 
A 1 428 GLY 428 432 432 GLY GLY A . n 
A 1 429 PRO 429 433 433 PRO PRO A . n 
A 1 430 TYR 430 434 434 TYR TYR A . n 
A 1 431 LYS 431 435 435 LYS LYS A . n 
A 1 432 PRO 432 436 436 PRO PRO A . n 
A 1 433 ASP 433 437 437 ASP ASP A . n 
A 1 434 HIS 434 438 438 HIS HIS A . n 
A 1 435 TYR 435 439 439 TYR TYR A . n 
A 1 436 ARG 436 440 440 ARG ARG A . n 
A 1 437 TYR 437 441 441 TYR TYR A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NAD 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NAD 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 NAD 1   501  501 NAD NAD A . 
C 3 ADE 1   502  502 ADE ADE A . 
D 4 SO4 1   503  1   SO4 SO4 A . 
E 4 SO4 1   504  4   SO4 SO4 A . 
F 5 HOH 1   601  228 HOH HOH A . 
F 5 HOH 2   602  105 HOH HOH A . 
F 5 HOH 3   603  354 HOH HOH A . 
F 5 HOH 4   604  413 HOH HOH A . 
F 5 HOH 5   605  310 HOH HOH A . 
F 5 HOH 6   606  366 HOH HOH A . 
F 5 HOH 7   607  184 HOH HOH A . 
F 5 HOH 8   608  311 HOH HOH A . 
F 5 HOH 9   609  116 HOH HOH A . 
F 5 HOH 10  610  467 HOH HOH A . 
F 5 HOH 11  611  192 HOH HOH A . 
F 5 HOH 12  612  346 HOH HOH A . 
F 5 HOH 13  613  344 HOH HOH A . 
F 5 HOH 14  614  375 HOH HOH A . 
F 5 HOH 15  615  471 HOH HOH A . 
F 5 HOH 16  616  138 HOH HOH A . 
F 5 HOH 17  617  456 HOH HOH A . 
F 5 HOH 18  618  497 HOH HOH A . 
F 5 HOH 19  619  71  HOH HOH A . 
F 5 HOH 20  620  16  HOH HOH A . 
F 5 HOH 21  621  396 HOH HOH A . 
F 5 HOH 22  622  165 HOH HOH A . 
F 5 HOH 23  623  434 HOH HOH A . 
F 5 HOH 24  624  75  HOH HOH A . 
F 5 HOH 25  625  3   HOH HOH A . 
F 5 HOH 26  626  247 HOH HOH A . 
F 5 HOH 27  627  179 HOH HOH A . 
F 5 HOH 28  628  29  HOH HOH A . 
F 5 HOH 29  629  400 HOH HOH A . 
F 5 HOH 30  630  504 HOH HOH A . 
F 5 HOH 31  631  517 HOH HOH A . 
F 5 HOH 32  632  243 HOH HOH A . 
F 5 HOH 33  633  466 HOH HOH A . 
F 5 HOH 34  634  420 HOH HOH A . 
F 5 HOH 35  635  85  HOH HOH A . 
F 5 HOH 36  636  327 HOH HOH A . 
F 5 HOH 37  637  274 HOH HOH A . 
F 5 HOH 38  638  209 HOH HOH A . 
F 5 HOH 39  639  449 HOH HOH A . 
F 5 HOH 40  640  94  HOH HOH A . 
F 5 HOH 41  641  10  HOH HOH A . 
F 5 HOH 42  642  195 HOH HOH A . 
F 5 HOH 43  643  198 HOH HOH A . 
F 5 HOH 44  644  312 HOH HOH A . 
F 5 HOH 45  645  47  HOH HOH A . 
F 5 HOH 46  646  208 HOH HOH A . 
F 5 HOH 47  647  508 HOH HOH A . 
F 5 HOH 48  648  25  HOH HOH A . 
F 5 HOH 49  649  188 HOH HOH A . 
F 5 HOH 50  650  54  HOH HOH A . 
F 5 HOH 51  651  448 HOH HOH A . 
F 5 HOH 52  652  190 HOH HOH A . 
F 5 HOH 53  653  90  HOH HOH A . 
F 5 HOH 54  654  217 HOH HOH A . 
F 5 HOH 55  655  35  HOH HOH A . 
F 5 HOH 56  656  140 HOH HOH A . 
F 5 HOH 57  657  65  HOH HOH A . 
F 5 HOH 58  658  88  HOH HOH A . 
F 5 HOH 59  659  57  HOH HOH A . 
F 5 HOH 60  660  93  HOH HOH A . 
F 5 HOH 61  661  178 HOH HOH A . 
F 5 HOH 62  662  331 HOH HOH A . 
F 5 HOH 63  663  68  HOH HOH A . 
F 5 HOH 64  664  233 HOH HOH A . 
F 5 HOH 65  665  87  HOH HOH A . 
F 5 HOH 66  666  256 HOH HOH A . 
F 5 HOH 67  667  212 HOH HOH A . 
F 5 HOH 68  668  330 HOH HOH A . 
F 5 HOH 69  669  191 HOH HOH A . 
F 5 HOH 70  670  81  HOH HOH A . 
F 5 HOH 71  671  46  HOH HOH A . 
F 5 HOH 72  672  23  HOH HOH A . 
F 5 HOH 73  673  97  HOH HOH A . 
F 5 HOH 74  674  127 HOH HOH A . 
F 5 HOH 75  675  62  HOH HOH A . 
F 5 HOH 76  676  115 HOH HOH A . 
F 5 HOH 77  677  82  HOH HOH A . 
F 5 HOH 78  678  397 HOH HOH A . 
F 5 HOH 79  679  258 HOH HOH A . 
F 5 HOH 80  680  86  HOH HOH A . 
F 5 HOH 81  681  271 HOH HOH A . 
F 5 HOH 82  682  74  HOH HOH A . 
F 5 HOH 83  683  117 HOH HOH A . 
F 5 HOH 84  684  493 HOH HOH A . 
F 5 HOH 85  685  113 HOH HOH A . 
F 5 HOH 86  686  89  HOH HOH A . 
F 5 HOH 87  687  129 HOH HOH A . 
F 5 HOH 88  688  108 HOH HOH A . 
F 5 HOH 89  689  8   HOH HOH A . 
F 5 HOH 90  690  103 HOH HOH A . 
F 5 HOH 91  691  362 HOH HOH A . 
F 5 HOH 92  692  421 HOH HOH A . 
F 5 HOH 93  693  224 HOH HOH A . 
F 5 HOH 94  694  30  HOH HOH A . 
F 5 HOH 95  695  67  HOH HOH A . 
F 5 HOH 96  696  164 HOH HOH A . 
F 5 HOH 97  697  141 HOH HOH A . 
F 5 HOH 98  698  27  HOH HOH A . 
F 5 HOH 99  699  284 HOH HOH A . 
F 5 HOH 100 700  345 HOH HOH A . 
F 5 HOH 101 701  231 HOH HOH A . 
F 5 HOH 102 702  177 HOH HOH A . 
F 5 HOH 103 703  44  HOH HOH A . 
F 5 HOH 104 704  414 HOH HOH A . 
F 5 HOH 105 705  492 HOH HOH A . 
F 5 HOH 106 706  225 HOH HOH A . 
F 5 HOH 107 707  128 HOH HOH A . 
F 5 HOH 108 708  257 HOH HOH A . 
F 5 HOH 109 709  52  HOH HOH A . 
F 5 HOH 110 710  418 HOH HOH A . 
F 5 HOH 111 711  18  HOH HOH A . 
F 5 HOH 112 712  361 HOH HOH A . 
F 5 HOH 113 713  40  HOH HOH A . 
F 5 HOH 114 714  42  HOH HOH A . 
F 5 HOH 115 715  5   HOH HOH A . 
F 5 HOH 116 716  296 HOH HOH A . 
F 5 HOH 117 717  111 HOH HOH A . 
F 5 HOH 118 718  349 HOH HOH A . 
F 5 HOH 119 719  326 HOH HOH A . 
F 5 HOH 120 720  20  HOH HOH A . 
F 5 HOH 121 721  17  HOH HOH A . 
F 5 HOH 122 722  339 HOH HOH A . 
F 5 HOH 123 723  66  HOH HOH A . 
F 5 HOH 124 724  158 HOH HOH A . 
F 5 HOH 125 725  15  HOH HOH A . 
F 5 HOH 126 726  106 HOH HOH A . 
F 5 HOH 127 727  11  HOH HOH A . 
F 5 HOH 128 728  193 HOH HOH A . 
F 5 HOH 129 729  246 HOH HOH A . 
F 5 HOH 130 730  33  HOH HOH A . 
F 5 HOH 131 731  96  HOH HOH A . 
F 5 HOH 132 732  305 HOH HOH A . 
F 5 HOH 133 733  73  HOH HOH A . 
F 5 HOH 134 734  350 HOH HOH A . 
F 5 HOH 135 735  240 HOH HOH A . 
F 5 HOH 136 736  9   HOH HOH A . 
F 5 HOH 137 737  235 HOH HOH A . 
F 5 HOH 138 738  487 HOH HOH A . 
F 5 HOH 139 739  204 HOH HOH A . 
F 5 HOH 140 740  13  HOH HOH A . 
F 5 HOH 141 741  144 HOH HOH A . 
F 5 HOH 142 742  512 HOH HOH A . 
F 5 HOH 143 743  64  HOH HOH A . 
F 5 HOH 144 744  6   HOH HOH A . 
F 5 HOH 145 745  166 HOH HOH A . 
F 5 HOH 146 746  1   HOH HOH A . 
F 5 HOH 147 747  469 HOH HOH A . 
F 5 HOH 148 748  2   HOH HOH A . 
F 5 HOH 149 749  389 HOH HOH A . 
F 5 HOH 150 750  459 HOH HOH A . 
F 5 HOH 151 751  70  HOH HOH A . 
F 5 HOH 152 752  92  HOH HOH A . 
F 5 HOH 153 753  22  HOH HOH A . 
F 5 HOH 154 754  232 HOH HOH A . 
F 5 HOH 155 755  280 HOH HOH A . 
F 5 HOH 156 756  53  HOH HOH A . 
F 5 HOH 157 757  196 HOH HOH A . 
F 5 HOH 158 758  244 HOH HOH A . 
F 5 HOH 159 759  112 HOH HOH A . 
F 5 HOH 160 760  39  HOH HOH A . 
F 5 HOH 161 761  145 HOH HOH A . 
F 5 HOH 162 762  7   HOH HOH A . 
F 5 HOH 163 763  63  HOH HOH A . 
F 5 HOH 164 764  132 HOH HOH A . 
F 5 HOH 165 765  391 HOH HOH A . 
F 5 HOH 166 766  248 HOH HOH A . 
F 5 HOH 167 767  495 HOH HOH A . 
F 5 HOH 168 768  383 HOH HOH A . 
F 5 HOH 169 769  154 HOH HOH A . 
F 5 HOH 170 770  199 HOH HOH A . 
F 5 HOH 171 771  169 HOH HOH A . 
F 5 HOH 172 772  120 HOH HOH A . 
F 5 HOH 173 773  147 HOH HOH A . 
F 5 HOH 174 774  24  HOH HOH A . 
F 5 HOH 175 775  341 HOH HOH A . 
F 5 HOH 176 776  122 HOH HOH A . 
F 5 HOH 177 777  436 HOH HOH A . 
F 5 HOH 178 778  12  HOH HOH A . 
F 5 HOH 179 779  220 HOH HOH A . 
F 5 HOH 180 780  60  HOH HOH A . 
F 5 HOH 181 781  186 HOH HOH A . 
F 5 HOH 182 782  69  HOH HOH A . 
F 5 HOH 183 783  83  HOH HOH A . 
F 5 HOH 184 784  130 HOH HOH A . 
F 5 HOH 185 785  59  HOH HOH A . 
F 5 HOH 186 786  167 HOH HOH A . 
F 5 HOH 187 787  55  HOH HOH A . 
F 5 HOH 188 788  180 HOH HOH A . 
F 5 HOH 189 789  393 HOH HOH A . 
F 5 HOH 190 790  202 HOH HOH A . 
F 5 HOH 191 791  168 HOH HOH A . 
F 5 HOH 192 792  61  HOH HOH A . 
F 5 HOH 193 793  238 HOH HOH A . 
F 5 HOH 194 794  307 HOH HOH A . 
F 5 HOH 195 795  273 HOH HOH A . 
F 5 HOH 196 796  41  HOH HOH A . 
F 5 HOH 197 797  149 HOH HOH A . 
F 5 HOH 198 798  468 HOH HOH A . 
F 5 HOH 199 799  444 HOH HOH A . 
F 5 HOH 200 800  31  HOH HOH A . 
F 5 HOH 201 801  118 HOH HOH A . 
F 5 HOH 202 802  259 HOH HOH A . 
F 5 HOH 203 803  109 HOH HOH A . 
F 5 HOH 204 804  230 HOH HOH A . 
F 5 HOH 205 805  28  HOH HOH A . 
F 5 HOH 206 806  325 HOH HOH A . 
F 5 HOH 207 807  510 HOH HOH A . 
F 5 HOH 208 808  215 HOH HOH A . 
F 5 HOH 209 809  455 HOH HOH A . 
F 5 HOH 210 810  137 HOH HOH A . 
F 5 HOH 211 811  395 HOH HOH A . 
F 5 HOH 212 812  100 HOH HOH A . 
F 5 HOH 213 813  433 HOH HOH A . 
F 5 HOH 214 814  26  HOH HOH A . 
F 5 HOH 215 815  102 HOH HOH A . 
F 5 HOH 216 816  151 HOH HOH A . 
F 5 HOH 217 817  136 HOH HOH A . 
F 5 HOH 218 818  161 HOH HOH A . 
F 5 HOH 219 819  4   HOH HOH A . 
F 5 HOH 220 820  282 HOH HOH A . 
F 5 HOH 221 821  268 HOH HOH A . 
F 5 HOH 222 822  342 HOH HOH A . 
F 5 HOH 223 823  84  HOH HOH A . 
F 5 HOH 224 824  390 HOH HOH A . 
F 5 HOH 225 825  163 HOH HOH A . 
F 5 HOH 226 826  207 HOH HOH A . 
F 5 HOH 227 827  123 HOH HOH A . 
F 5 HOH 228 828  19  HOH HOH A . 
F 5 HOH 229 829  347 HOH HOH A . 
F 5 HOH 230 830  370 HOH HOH A . 
F 5 HOH 231 831  333 HOH HOH A . 
F 5 HOH 232 832  48  HOH HOH A . 
F 5 HOH 233 833  159 HOH HOH A . 
F 5 HOH 234 834  472 HOH HOH A . 
F 5 HOH 235 835  148 HOH HOH A . 
F 5 HOH 236 836  304 HOH HOH A . 
F 5 HOH 237 837  265 HOH HOH A . 
F 5 HOH 238 838  185 HOH HOH A . 
F 5 HOH 239 839  37  HOH HOH A . 
F 5 HOH 240 840  461 HOH HOH A . 
F 5 HOH 241 841  183 HOH HOH A . 
F 5 HOH 242 842  32  HOH HOH A . 
F 5 HOH 243 843  463 HOH HOH A . 
F 5 HOH 244 844  430 HOH HOH A . 
F 5 HOH 245 845  201 HOH HOH A . 
F 5 HOH 246 846  314 HOH HOH A . 
F 5 HOH 247 847  99  HOH HOH A . 
F 5 HOH 248 848  428 HOH HOH A . 
F 5 HOH 249 849  353 HOH HOH A . 
F 5 HOH 250 850  43  HOH HOH A . 
F 5 HOH 251 851  385 HOH HOH A . 
F 5 HOH 252 852  452 HOH HOH A . 
F 5 HOH 253 853  351 HOH HOH A . 
F 5 HOH 254 854  77  HOH HOH A . 
F 5 HOH 255 855  227 HOH HOH A . 
F 5 HOH 256 856  249 HOH HOH A . 
F 5 HOH 257 857  237 HOH HOH A . 
F 5 HOH 258 858  114 HOH HOH A . 
F 5 HOH 259 859  478 HOH HOH A . 
F 5 HOH 260 860  485 HOH HOH A . 
F 5 HOH 261 861  176 HOH HOH A . 
F 5 HOH 262 862  143 HOH HOH A . 
F 5 HOH 263 863  317 HOH HOH A . 
F 5 HOH 264 864  214 HOH HOH A . 
F 5 HOH 265 865  160 HOH HOH A . 
F 5 HOH 266 866  234 HOH HOH A . 
F 5 HOH 267 867  264 HOH HOH A . 
F 5 HOH 268 868  174 HOH HOH A . 
F 5 HOH 269 869  454 HOH HOH A . 
F 5 HOH 270 870  213 HOH HOH A . 
F 5 HOH 271 871  80  HOH HOH A . 
F 5 HOH 272 872  95  HOH HOH A . 
F 5 HOH 273 873  245 HOH HOH A . 
F 5 HOH 274 874  403 HOH HOH A . 
F 5 HOH 275 875  431 HOH HOH A . 
F 5 HOH 276 876  484 HOH HOH A . 
F 5 HOH 277 877  51  HOH HOH A . 
F 5 HOH 278 878  72  HOH HOH A . 
F 5 HOH 279 879  376 HOH HOH A . 
F 5 HOH 280 880  76  HOH HOH A . 
F 5 HOH 281 881  516 HOH HOH A . 
F 5 HOH 282 882  38  HOH HOH A . 
F 5 HOH 283 883  239 HOH HOH A . 
F 5 HOH 284 884  36  HOH HOH A . 
F 5 HOH 285 885  263 HOH HOH A . 
F 5 HOH 286 886  297 HOH HOH A . 
F 5 HOH 287 887  146 HOH HOH A . 
F 5 HOH 288 888  79  HOH HOH A . 
F 5 HOH 289 889  91  HOH HOH A . 
F 5 HOH 290 890  119 HOH HOH A . 
F 5 HOH 291 891  101 HOH HOH A . 
F 5 HOH 292 892  416 HOH HOH A . 
F 5 HOH 293 893  56  HOH HOH A . 
F 5 HOH 294 894  14  HOH HOH A . 
F 5 HOH 295 895  324 HOH HOH A . 
F 5 HOH 296 896  290 HOH HOH A . 
F 5 HOH 297 897  150 HOH HOH A . 
F 5 HOH 298 898  125 HOH HOH A . 
F 5 HOH 299 899  302 HOH HOH A . 
F 5 HOH 300 900  142 HOH HOH A . 
F 5 HOH 301 901  153 HOH HOH A . 
F 5 HOH 302 902  475 HOH HOH A . 
F 5 HOH 303 903  135 HOH HOH A . 
F 5 HOH 304 904  432 HOH HOH A . 
F 5 HOH 305 905  423 HOH HOH A . 
F 5 HOH 306 906  293 HOH HOH A . 
F 5 HOH 307 907  255 HOH HOH A . 
F 5 HOH 308 908  242 HOH HOH A . 
F 5 HOH 309 909  447 HOH HOH A . 
F 5 HOH 310 910  203 HOH HOH A . 
F 5 HOH 311 911  415 HOH HOH A . 
F 5 HOH 312 912  377 HOH HOH A . 
F 5 HOH 313 913  124 HOH HOH A . 
F 5 HOH 314 914  329 HOH HOH A . 
F 5 HOH 315 915  98  HOH HOH A . 
F 5 HOH 316 916  133 HOH HOH A . 
F 5 HOH 317 917  365 HOH HOH A . 
F 5 HOH 318 918  175 HOH HOH A . 
F 5 HOH 319 919  210 HOH HOH A . 
F 5 HOH 320 920  205 HOH HOH A . 
F 5 HOH 321 921  270 HOH HOH A . 
F 5 HOH 322 922  378 HOH HOH A . 
F 5 HOH 323 923  78  HOH HOH A . 
F 5 HOH 324 924  194 HOH HOH A . 
F 5 HOH 325 925  382 HOH HOH A . 
F 5 HOH 326 926  386 HOH HOH A . 
F 5 HOH 327 927  49  HOH HOH A . 
F 5 HOH 328 928  303 HOH HOH A . 
F 5 HOH 329 929  152 HOH HOH A . 
F 5 HOH 330 930  172 HOH HOH A . 
F 5 HOH 331 931  170 HOH HOH A . 
F 5 HOH 332 932  126 HOH HOH A . 
F 5 HOH 333 933  251 HOH HOH A . 
F 5 HOH 334 934  445 HOH HOH A . 
F 5 HOH 335 935  309 HOH HOH A . 
F 5 HOH 336 936  58  HOH HOH A . 
F 5 HOH 337 937  223 HOH HOH A . 
F 5 HOH 338 938  458 HOH HOH A . 
F 5 HOH 339 939  181 HOH HOH A . 
F 5 HOH 340 940  261 HOH HOH A . 
F 5 HOH 341 941  356 HOH HOH A . 
F 5 HOH 342 942  222 HOH HOH A . 
F 5 HOH 343 943  291 HOH HOH A . 
F 5 HOH 344 944  200 HOH HOH A . 
F 5 HOH 345 945  435 HOH HOH A . 
F 5 HOH 346 946  440 HOH HOH A . 
F 5 HOH 347 947  402 HOH HOH A . 
F 5 HOH 348 948  323 HOH HOH A . 
F 5 HOH 349 949  134 HOH HOH A . 
F 5 HOH 350 950  491 HOH HOH A . 
F 5 HOH 351 951  411 HOH HOH A . 
F 5 HOH 352 952  211 HOH HOH A . 
F 5 HOH 353 953  392 HOH HOH A . 
F 5 HOH 354 954  364 HOH HOH A . 
F 5 HOH 355 955  460 HOH HOH A . 
F 5 HOH 356 956  283 HOH HOH A . 
F 5 HOH 357 957  482 HOH HOH A . 
F 5 HOH 358 958  515 HOH HOH A . 
F 5 HOH 359 959  503 HOH HOH A . 
F 5 HOH 360 960  380 HOH HOH A . 
F 5 HOH 361 961  334 HOH HOH A . 
F 5 HOH 362 962  318 HOH HOH A . 
F 5 HOH 363 963  226 HOH HOH A . 
F 5 HOH 364 964  338 HOH HOH A . 
F 5 HOH 365 965  451 HOH HOH A . 
F 5 HOH 366 966  481 HOH HOH A . 
F 5 HOH 367 967  502 HOH HOH A . 
F 5 HOH 368 968  496 HOH HOH A . 
F 5 HOH 369 969  281 HOH HOH A . 
F 5 HOH 370 970  507 HOH HOH A . 
F 5 HOH 371 971  301 HOH HOH A . 
F 5 HOH 372 972  262 HOH HOH A . 
F 5 HOH 373 973  470 HOH HOH A . 
F 5 HOH 374 974  442 HOH HOH A . 
F 5 HOH 375 975  322 HOH HOH A . 
F 5 HOH 376 976  260 HOH HOH A . 
F 5 HOH 377 977  313 HOH HOH A . 
F 5 HOH 378 978  298 HOH HOH A . 
F 5 HOH 379 979  473 HOH HOH A . 
F 5 HOH 380 980  278 HOH HOH A . 
F 5 HOH 381 981  321 HOH HOH A . 
F 5 HOH 382 982  157 HOH HOH A . 
F 5 HOH 383 983  498 HOH HOH A . 
F 5 HOH 384 984  511 HOH HOH A . 
F 5 HOH 385 985  335 HOH HOH A . 
F 5 HOH 386 986  357 HOH HOH A . 
F 5 HOH 387 987  131 HOH HOH A . 
F 5 HOH 388 988  446 HOH HOH A . 
F 5 HOH 389 989  404 HOH HOH A . 
F 5 HOH 390 990  107 HOH HOH A . 
F 5 HOH 391 991  221 HOH HOH A . 
F 5 HOH 392 992  337 HOH HOH A . 
F 5 HOH 393 993  410 HOH HOH A . 
F 5 HOH 394 994  289 HOH HOH A . 
F 5 HOH 395 995  45  HOH HOH A . 
F 5 HOH 396 996  371 HOH HOH A . 
F 5 HOH 397 997  171 HOH HOH A . 
F 5 HOH 398 998  352 HOH HOH A . 
F 5 HOH 399 999  269 HOH HOH A . 
F 5 HOH 400 1000 187 HOH HOH A . 
F 5 HOH 401 1001 398 HOH HOH A . 
F 5 HOH 402 1002 363 HOH HOH A . 
F 5 HOH 403 1003 34  HOH HOH A . 
F 5 HOH 404 1004 316 HOH HOH A . 
F 5 HOH 405 1005 450 HOH HOH A . 
F 5 HOH 406 1006 373 HOH HOH A . 
F 5 HOH 407 1007 156 HOH HOH A . 
F 5 HOH 408 1008 162 HOH HOH A . 
F 5 HOH 409 1009 272 HOH HOH A . 
F 5 HOH 410 1010 509 HOH HOH A . 
F 5 HOH 411 1011 479 HOH HOH A . 
F 5 HOH 412 1012 182 HOH HOH A . 
F 5 HOH 413 1013 506 HOH HOH A . 
F 5 HOH 414 1014 426 HOH HOH A . 
F 5 HOH 415 1015 360 HOH HOH A . 
F 5 HOH 416 1016 499 HOH HOH A . 
F 5 HOH 417 1017 50  HOH HOH A . 
F 5 HOH 418 1018 332 HOH HOH A . 
F 5 HOH 419 1019 292 HOH HOH A . 
F 5 HOH 420 1020 513 HOH HOH A . 
F 5 HOH 421 1021 236 HOH HOH A . 
F 5 HOH 422 1022 197 HOH HOH A . 
F 5 HOH 423 1023 206 HOH HOH A . 
F 5 HOH 424 1024 287 HOH HOH A . 
F 5 HOH 425 1025 219 HOH HOH A . 
F 5 HOH 426 1026 422 HOH HOH A . 
F 5 HOH 427 1027 336 HOH HOH A . 
F 5 HOH 428 1028 409 HOH HOH A . 
F 5 HOH 429 1029 401 HOH HOH A . 
F 5 HOH 430 1030 514 HOH HOH A . 
F 5 HOH 431 1031 381 HOH HOH A . 
F 5 HOH 432 1032 425 HOH HOH A . 
F 5 HOH 433 1033 490 HOH HOH A . 
F 5 HOH 434 1034 110 HOH HOH A . 
F 5 HOH 435 1035 320 HOH HOH A . 
F 5 HOH 436 1036 300 HOH HOH A . 
F 5 HOH 437 1037 462 HOH HOH A . 
F 5 HOH 438 1038 267 HOH HOH A . 
F 5 HOH 439 1039 441 HOH HOH A . 
F 5 HOH 440 1040 464 HOH HOH A . 
F 5 HOH 441 1041 340 HOH HOH A . 
F 5 HOH 442 1042 276 HOH HOH A . 
F 5 HOH 443 1043 286 HOH HOH A . 
F 5 HOH 444 1044 359 HOH HOH A . 
F 5 HOH 445 1045 279 HOH HOH A . 
F 5 HOH 446 1046 319 HOH HOH A . 
F 5 HOH 447 1047 374 HOH HOH A . 
F 5 HOH 448 1048 275 HOH HOH A . 
F 5 HOH 449 1049 355 HOH HOH A . 
F 5 HOH 450 1050 241 HOH HOH A . 
F 5 HOH 451 1051 387 HOH HOH A . 
F 5 HOH 452 1052 399 HOH HOH A . 
F 5 HOH 453 1053 424 HOH HOH A . 
F 5 HOH 454 1054 489 HOH HOH A . 
F 5 HOH 455 1055 253 HOH HOH A . 
F 5 HOH 456 1056 500 HOH HOH A . 
F 5 HOH 457 1057 465 HOH HOH A . 
F 5 HOH 458 1058 429 HOH HOH A . 
F 5 HOH 459 1059 121 HOH HOH A . 
F 5 HOH 460 1060 328 HOH HOH A . 
F 5 HOH 461 1061 501 HOH HOH A . 
F 5 HOH 462 1062 104 HOH HOH A . 
F 5 HOH 463 1063 384 HOH HOH A . 
F 5 HOH 464 1064 372 HOH HOH A . 
F 5 HOH 465 1065 139 HOH HOH A . 
F 5 HOH 466 1066 155 HOH HOH A . 
F 5 HOH 467 1067 474 HOH HOH A . 
F 5 HOH 468 1068 218 HOH HOH A . 
F 5 HOH 469 1069 427 HOH HOH A . 
F 5 HOH 470 1070 367 HOH HOH A . 
F 5 HOH 471 1071 488 HOH HOH A . 
F 5 HOH 472 1072 419 HOH HOH A . 
F 5 HOH 473 1073 308 HOH HOH A . 
F 5 HOH 474 1074 285 HOH HOH A . 
F 5 HOH 475 1075 229 HOH HOH A . 
F 5 HOH 476 1076 405 HOH HOH A . 
F 5 HOH 477 1077 358 HOH HOH A . 
F 5 HOH 478 1078 476 HOH HOH A . 
F 5 HOH 479 1079 266 HOH HOH A . 
F 5 HOH 480 1080 412 HOH HOH A . 
F 5 HOH 481 1081 348 HOH HOH A . 
F 5 HOH 482 1082 417 HOH HOH A . 
F 5 HOH 483 1083 189 HOH HOH A . 
F 5 HOH 484 1084 294 HOH HOH A . 
F 5 HOH 485 1085 252 HOH HOH A . 
F 5 HOH 486 1086 388 HOH HOH A . 
F 5 HOH 487 1087 369 HOH HOH A . 
F 5 HOH 488 1088 315 HOH HOH A . 
F 5 HOH 489 1089 368 HOH HOH A . 
F 5 HOH 490 1090 173 HOH HOH A . 
F 5 HOH 491 1091 438 HOH HOH A . 
F 5 HOH 492 1092 480 HOH HOH A . 
F 5 HOH 493 1093 306 HOH HOH A . 
F 5 HOH 494 1094 295 HOH HOH A . 
F 5 HOH 495 1095 407 HOH HOH A . 
F 5 HOH 496 1096 439 HOH HOH A . 
F 5 HOH 497 1097 299 HOH HOH A . 
F 5 HOH 498 1098 21  HOH HOH A . 
F 5 HOH 499 1099 250 HOH HOH A . 
F 5 HOH 500 1100 453 HOH HOH A . 
F 5 HOH 501 1101 216 HOH HOH A . 
F 5 HOH 502 1102 483 HOH HOH A . 
F 5 HOH 503 1103 443 HOH HOH A . 
F 5 HOH 504 1104 477 HOH HOH A . 
F 5 HOH 505 1105 406 HOH HOH A . 
F 5 HOH 506 1106 254 HOH HOH A . 
F 5 HOH 507 1107 518 HOH HOH A . 
F 5 HOH 508 1108 277 HOH HOH A . 
# 
_pdbx_unobs_or_zero_occ_atoms.id               1 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag     N 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag   0 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id     A 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id     ADE 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id      502 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id     C8 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id     ? 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id    C 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id    ADE 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id     ? 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id    C8 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? 5.8.0419 1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-3000    ? ? ? 7.21     2 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.27     3 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? HKL-3000    ? ? ? 7.21     4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .        5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8WZ9 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     130.820 
_cell.length_a_esd                 ? 
_cell.length_b                     130.820 
_cell.length_b_esd                 ? 
_cell.length_c                     117.118 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8WZ9 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                180 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 62 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8WZ9 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.07 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          59.97 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.5 M Ammonium sulfate
1.0 M Lithium sulfate
0.1 M Sodium citrate pH 5.6
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-07-17 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    Si111 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97861 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL18U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97861 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL18U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8WZ9 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.649 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     71306 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                38.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          50.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.017 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.102 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.103 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.649 
_reflns_shell.d_res_low                                     1.71 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             70987 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.806 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.350 
_refine.aniso_B[1][2]                            -0.175 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            -0.350 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            1.134 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               25.143 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.971 
_refine.correlation_coeff_Fo_to_Fc_free          0.968 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8WZ9 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.649 
_refine.ls_d_res_low                             25.511 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     71071 
_refine.ls_number_reflns_R_free                  3525 
_refine.ls_number_reflns_R_work                  67546 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.651 
_refine.ls_percent_reflns_R_free                 4.960 
_refine.ls_R_factor_all                          0.176 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.1816 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1760 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      0.172 
_refine.ls_wR_factor_R_work                      0.169 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      Q5ZTY7 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.081 
_refine.pdbx_overall_ESU_R_Free                  0.073 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    0.9730 
_refine.pdbx_average_fsc_free                    0.9695 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.649 
_refine_hist.d_res_low                        25.511 
_refine_hist.number_atoms_solvent             508 
_refine_hist.number_atoms_total               3878 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3306 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         64 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  0.012  3434 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.016  3257 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.405  1.652  4668 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.681  1.580  7489 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.418  5.000  426  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 4.314  5.000  17   ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.327  5.000  2    ? r_dihedral_angle_other_2_deg   ? ? 
'X-RAY DIFFRACTION' ? 15.107 10.000 582  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 17.621 10.000 150  ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.068  0.200  532  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.004  0.020  4025 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.003  0.020  757  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.215  0.200  686  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.207  0.200  3098 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.182  0.200  1722 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.077  0.200  1796 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.171  0.200  369  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.111  0.200  23   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.189  0.200  233  ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.210  0.200  89   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 2.236  2.574  1707 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.235  2.574  1707 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 3.022  4.610  2132 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 3.021  4.609  2133 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.669  2.911  1727 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.676  2.899  1719 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.370  5.191  2536 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.379  5.169  2525 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 6.566  29.177 4116 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 6.264  26.884 3939 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.649 1.692  5185 . 280 4853 98.9971  . 0.269 . . 0.269 . . . . . 0.234 . 20 . 0.952 0.948 0.270 
'X-RAY DIFFRACTION' 1.692 1.738  5035 . 218 4815 99.9603  . 0.258 . . 0.258 . . . . . 0.222 . 20 . 0.957 0.955 0.252 
'X-RAY DIFFRACTION' 1.738 1.788  4899 . 247 4650 99.9592  . 0.241 . . 0.240 . . . . . 0.206 . 20 . 0.962 0.958 0.263 
'X-RAY DIFFRACTION' 1.788 1.843  4789 . 217 4567 99.8956  . 0.228 . . 0.227 . . . . . 0.195 . 20 . 0.966 0.959 0.249 
'X-RAY DIFFRACTION' 1.843 1.903  4634 . 260 4372 99.9568  . 0.226 . . 0.224 . . . . . 0.191 . 20 . 0.969 0.962 0.249 
'X-RAY DIFFRACTION' 1.903 1.969  4461 . 223 4233 99.8879  . 0.227 . . 0.227 . . . . . 0.193 . 20 . 0.967 0.963 0.239 
'X-RAY DIFFRACTION' 1.969 2.043  4364 . 229 4130 99.8854  . 0.206 . . 0.204 . . . . . 0.179 . 20 . 0.973 0.967 0.230 
'X-RAY DIFFRACTION' 2.043 2.126  4162 . 215 3943 99.9039  . 0.199 . . 0.198 . . . . . 0.173 . 20 . 0.975 0.974 0.208 
'X-RAY DIFFRACTION' 2.126 2.220  4037 . 220 3813 99.9009  . 0.183 . . 0.181 . . . . . 0.162 . 20 . 0.979 0.970 0.212 
'X-RAY DIFFRACTION' 2.220 2.327  3835 . 190 3642 99.9218  . 0.190 . . 0.189 . . . . . 0.170 . 20 . 0.978 0.974 0.201 
'X-RAY DIFFRACTION' 2.327 2.452  3667 . 175 3491 99.9727  . 0.175 . . 0.173 . . . . . 0.160 . 20 . 0.981 0.977 0.197 
'X-RAY DIFFRACTION' 2.452 2.599  3479 . 166 3312 99.9713  . 0.172 . . 0.173 . . . . . 0.162 . 20 . 0.981 0.984 0.156 
'X-RAY DIFFRACTION' 2.599 2.777  3292 . 164 3124 99.8785  . 0.166 . . 0.167 . . . . . 0.161 . 20 . 0.982 0.982 0.161 
'X-RAY DIFFRACTION' 2.777 2.996  3077 . 157 2918 99.9350  . 0.164 . . 0.164 . . . . . 0.161 . 20 . 0.983 0.981 0.173 
'X-RAY DIFFRACTION' 2.996 3.278  2845 . 138 2707 100.0000 . 0.174 . . 0.174 . . . . . 0.177 . 20 . 0.981 0.982 0.177 
'X-RAY DIFFRACTION' 3.278 3.657  2615 . 102 2513 100.0000 . 0.157 . . 0.158 . . . . . 0.165 . 20 . 0.985 0.986 0.154 
'X-RAY DIFFRACTION' 3.657 4.208  2302 . 107 2195 100.0000 . 0.140 . . 0.139 . . . . . 0.151 . 20 . 0.988 0.985 0.143 
'X-RAY DIFFRACTION' 4.208 5.119  1992 . 107 1881 99.7992  . 0.132 . . 0.132 . . . . . 0.151 . 20 . 0.990 0.989 0.135 
'X-RAY DIFFRACTION' 5.119 7.098  1601 . 60  1504 97.6889  . 0.178 . . 0.179 . . . . . 0.200 . 20 . 0.983 0.989 0.150 
'X-RAY DIFFRACTION' 7.098 25.511 1015 . 50  883  91.9212  . 0.149 . . 0.149 . . . . . 0.176 . 20 . 0.986 0.989 0.142 
# 
_struct.entry_id                     8WZ9 
_struct.title                        
'The crystal structure of Legionella pneumophila adenosylhomocysteinase Lpg2021 in ternary complex with NAD and adenine' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8WZ9 
_struct_keywords.text            'Legionella pneumophila, SAH hydrolase, ADE, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A2S6F4T2_LEGPN 
_struct_ref.pdbx_db_accession          A0A2S6F4T2 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;QDYKVAEISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVALGAEVRWSSCNIFST
QDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQVVHQKHPKLLTAIKGVSEETTTGVAR
LYEMAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCAQALRGQGATVLVAE
IDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQSLKQYQWENIKPQV
DHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLDEKVARLHLGRIGAK
LTQLSNEQADYIGVDKNGPYKPDHYRY
;
_struct_ref.pdbx_align_begin           15 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8WZ9 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 11 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 437 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A2S6F4T2 
_struct_ref_seq.db_align_beg                  15 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  441 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       15 
_struct_ref_seq.pdbx_auth_seq_align_end       441 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8WZ9 MET A 1  ? UNP A0A2S6F4T2 ? ? 'initiating methionine' 5  1  
1 8WZ9 GLY A 2  ? UNP A0A2S6F4T2 ? ? 'expression tag'        6  2  
1 8WZ9 HIS A 3  ? UNP A0A2S6F4T2 ? ? 'expression tag'        7  3  
1 8WZ9 HIS A 4  ? UNP A0A2S6F4T2 ? ? 'expression tag'        8  4  
1 8WZ9 HIS A 5  ? UNP A0A2S6F4T2 ? ? 'expression tag'        9  5  
1 8WZ9 HIS A 6  ? UNP A0A2S6F4T2 ? ? 'expression tag'        10 6  
1 8WZ9 HIS A 7  ? UNP A0A2S6F4T2 ? ? 'expression tag'        11 7  
1 8WZ9 HIS A 8  ? UNP A0A2S6F4T2 ? ? 'expression tag'        12 8  
1 8WZ9 HIS A 9  ? UNP A0A2S6F4T2 ? ? 'expression tag'        13 9  
1 8WZ9 HIS A 10 ? UNP A0A2S6F4T2 ? ? 'expression tag'        14 10 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 10460 ? 
1 MORE         -99   ? 
1 'SSA (A^2)'  30370 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000  
0.0000000000 0.0000000000    0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 4_545 -x,-y-1,z -1.0000000000 0.0000000000 0.0000000000 65.4100000000 0.0000000000 -1.0000000000 
0.0000000000 -113.2934433231 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 17  ? SER A 19  ? GLU A 21  SER A 23  5 ? 3  
HELX_P HELX_P2  AA2 LEU A 20  ? GLU A 34  ? LEU A 24  GLU A 38  1 ? 15 
HELX_P HELX_P3  AA3 MET A 35  ? SER A 46  ? MET A 39  SER A 50  1 ? 12 
HELX_P HELX_P4  AA4 THR A 63  ? LEU A 76  ? THR A 67  LEU A 80  1 ? 14 
HELX_P HELX_P5  AA5 GLN A 91  ? LYS A 101 ? GLN A 95  LYS A 105 1 ? 11 
HELX_P HELX_P6  AA6 THR A 112 ? THR A 123 ? THR A 116 THR A 127 1 ? 12 
HELX_P HELX_P7  AA7 LEU A 124 ? SER A 125 ? LEU A 128 SER A 129 5 ? 2  
HELX_P HELX_P8  AA8 GLY A 126 ? TRP A 130 ? GLY A 130 TRP A 134 5 ? 5  
HELX_P HELX_P9  AA9 GLY A 140 ? HIS A 150 ? GLY A 144 HIS A 154 1 ? 11 
HELX_P HELX_P10 AB1 HIS A 150 ? THR A 155 ? HIS A 154 THR A 159 1 ? 6  
HELX_P HELX_P11 AB2 THR A 164 ? HIS A 177 ? THR A 168 HIS A 181 1 ? 14 
HELX_P HELX_P12 AB3 ALA A 190 ? LYS A 195 ? ALA A 194 LYS A 199 1 ? 6  
HELX_P HELX_P13 AB4 PHE A 196 ? THR A 214 ? PHE A 200 THR A 218 1 ? 19 
HELX_P HELX_P14 AB5 GLY A 229 ? GLN A 242 ? GLY A 233 GLN A 246 1 ? 14 
HELX_P HELX_P15 AB6 ASP A 252 ? GLU A 262 ? ASP A 256 GLU A 266 1 ? 11 
HELX_P HELX_P16 AB7 THR A 268 ? ALA A 273 ? THR A 272 ALA A 277 1 ? 6  
HELX_P HELX_P17 AB8 GLU A 274 ? VAL A 276 ? GLU A 278 VAL A 280 5 ? 3  
HELX_P HELX_P18 AB9 THR A 290 ? MET A 297 ? THR A 294 MET A 301 1 ? 8  
HELX_P HELX_P19 AC1 PHE A 309 ? ILE A 313 ? PHE A 313 ILE A 317 5 ? 5  
HELX_P HELX_P20 AC2 ASP A 314 ? LYS A 319 ? ASP A 318 LYS A 323 5 ? 6  
HELX_P HELX_P21 AC3 GLU A 346 ? ARG A 348 ? GLU A 350 ARG A 352 5 ? 3  
HELX_P HELX_P22 AC4 LEU A 349 ? CYS A 354 ? LEU A 353 CYS A 358 1 ? 6  
HELX_P HELX_P23 AC5 PRO A 359 ? SER A 381 ? PRO A 363 SER A 385 1 ? 23 
HELX_P HELX_P24 AC6 SER A 382 ? TYR A 384 ? SER A 386 TYR A 388 5 ? 3  
HELX_P HELX_P25 AC7 PRO A 392 ? GLY A 405 ? PRO A 396 GLY A 409 1 ? 14 
HELX_P HELX_P26 AC8 SER A 415 ? GLY A 423 ? SER A 419 GLY A 427 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           428 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            432 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    429 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     433 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -0.25 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA2 6 7 ? anti-parallel 
AA2 7 8 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 105 ? PHE A 106 ? VAL A 109 PHE A 110 
AA1 2 GLU A 79  ? SER A 83  ? GLU A 83  SER A 87  
AA1 3 ARG A 55  ? CYS A 59  ? ARG A 59  CYS A 63  
AA1 4 LEU A 134 ? ASP A 137 ? LEU A 138 ASP A 141 
AA1 5 VAL A 160 ? GLU A 162 ? VAL A 164 GLU A 166 
AA1 6 ALA A 184 ? ASN A 186 ? ALA A 188 ASN A 190 
AA1 7 VAL A 388 ? TYR A 389 ? VAL A 392 TYR A 393 
AA2 1 ARG A 265 ? VAL A 266 ? ARG A 269 VAL A 270 
AA2 2 THR A 245 ? ALA A 249 ? THR A 249 ALA A 253 
AA2 3 VAL A 222 ? LEU A 226 ? VAL A 226 LEU A 230 
AA2 4 ILE A 278 ? THR A 281 ? ILE A 282 THR A 285 
AA2 5 ALA A 301 ? ASN A 305 ? ALA A 305 ASN A 309 
AA2 6 ARG A 340 ? LEU A 344 ? ARG A 344 LEU A 348 
AA2 7 VAL A 330 ? ILE A 334 ? VAL A 334 ILE A 338 
AA2 8 GLN A 322 ? LYS A 327 ? GLN A 326 LYS A 331 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O PHE A 106 ? O PHE A 110 N TRP A 82  ? N TRP A 86  
AA1 2 3 O GLU A 79  ? O GLU A 83  N ILE A 56  ? N ILE A 60  
AA1 3 4 N ALA A 57  ? N ALA A 61  O LEU A 136 ? O LEU A 140 
AA1 4 5 N ASP A 137 ? N ASP A 141 O SER A 161 ? O SER A 165 
AA1 5 6 N VAL A 160 ? N VAL A 164 O ILE A 185 ? O ILE A 189 
AA1 6 7 N ASN A 186 ? N ASN A 190 O TYR A 389 ? O TYR A 393 
AA2 1 2 O ARG A 265 ? O ARG A 269 N VAL A 248 ? N VAL A 252 
AA2 2 3 O LEU A 247 ? O LEU A 251 N ALA A 223 ? N ALA A 227 
AA2 3 4 N LEU A 226 ? N LEU A 230 O VAL A 280 ? O VAL A 284 
AA2 4 5 N VAL A 279 ? N VAL A 283 O ILE A 302 ? O ILE A 306 
AA2 5 6 N ALA A 301 ? N ALA A 305 O ILE A 342 ? O ILE A 346 
AA2 6 7 O ILE A 343 ? O ILE A 347 N ASP A 331 ? N ASP A 335 
AA2 7 8 O HIS A 332 ? O HIS A 336 N GLU A 324 ? N GLU A 328 
# 
_pdbx_entry_details.entry_id                   8WZ9 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 HIS A 65  ? ? -29.84  118.16  
2 1 LYS A 197 ? ? -108.28 -69.25  
3 1 PHE A 200 ? ? -127.77 -70.37  
4 1 ASP A 219 ? ? -99.01  36.03   
5 1 LEU A 353 ? ? -36.06  112.47  
6 1 ALA A 359 ? ? -138.89 -150.01 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 602  ? F HOH . 
2 1 A HOH 651  ? F HOH . 
3 1 A HOH 784  ? F HOH . 
4 1 A HOH 974  ? F HOH . 
5 1 A HOH 1100 ? F HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1105 ? 5.99 . 
2 1 O ? A HOH 1106 ? 6.04 . 
3 1 O ? A HOH 1107 ? 6.83 . 
4 1 O ? A HOH 1108 ? 6.88 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 5  ? A MET 1  
2  1 Y 1 A GLY 6  ? A GLY 2  
3  1 Y 1 A HIS 7  ? A HIS 3  
4  1 Y 1 A HIS 8  ? A HIS 4  
5  1 Y 1 A HIS 9  ? A HIS 5  
6  1 Y 1 A HIS 10 ? A HIS 6  
7  1 Y 1 A HIS 11 ? A HIS 7  
8  1 Y 1 A HIS 12 ? A HIS 8  
9  1 Y 1 A HIS 13 ? A HIS 9  
10 1 Y 1 A HIS 14 ? A HIS 10 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ADE N9   N Y N 1   
ADE C8   C Y N 2   
ADE N7   N Y N 3   
ADE C5   C Y N 4   
ADE C6   C Y N 5   
ADE N6   N N N 6   
ADE N1   N Y N 7   
ADE C2   C Y N 8   
ADE N3   N Y N 9   
ADE C4   C Y N 10  
ADE HN9  H N N 11  
ADE H8   H N N 12  
ADE HN61 H N N 13  
ADE HN62 H N N 14  
ADE H2   H N N 15  
ALA N    N N N 16  
ALA CA   C N S 17  
ALA C    C N N 18  
ALA O    O N N 19  
ALA CB   C N N 20  
ALA OXT  O N N 21  
ALA H    H N N 22  
ALA H2   H N N 23  
ALA HA   H N N 24  
ALA HB1  H N N 25  
ALA HB2  H N N 26  
ALA HB3  H N N 27  
ALA HXT  H N N 28  
ARG N    N N N 29  
ARG CA   C N S 30  
ARG C    C N N 31  
ARG O    O N N 32  
ARG CB   C N N 33  
ARG CG   C N N 34  
ARG CD   C N N 35  
ARG NE   N N N 36  
ARG CZ   C N N 37  
ARG NH1  N N N 38  
ARG NH2  N N N 39  
ARG OXT  O N N 40  
ARG H    H N N 41  
ARG H2   H N N 42  
ARG HA   H N N 43  
ARG HB2  H N N 44  
ARG HB3  H N N 45  
ARG HG2  H N N 46  
ARG HG3  H N N 47  
ARG HD2  H N N 48  
ARG HD3  H N N 49  
ARG HE   H N N 50  
ARG HH11 H N N 51  
ARG HH12 H N N 52  
ARG HH21 H N N 53  
ARG HH22 H N N 54  
ARG HXT  H N N 55  
ASN N    N N N 56  
ASN CA   C N S 57  
ASN C    C N N 58  
ASN O    O N N 59  
ASN CB   C N N 60  
ASN CG   C N N 61  
ASN OD1  O N N 62  
ASN ND2  N N N 63  
ASN OXT  O N N 64  
ASN H    H N N 65  
ASN H2   H N N 66  
ASN HA   H N N 67  
ASN HB2  H N N 68  
ASN HB3  H N N 69  
ASN HD21 H N N 70  
ASN HD22 H N N 71  
ASN HXT  H N N 72  
ASP N    N N N 73  
ASP CA   C N S 74  
ASP C    C N N 75  
ASP O    O N N 76  
ASP CB   C N N 77  
ASP CG   C N N 78  
ASP OD1  O N N 79  
ASP OD2  O N N 80  
ASP OXT  O N N 81  
ASP H    H N N 82  
ASP H2   H N N 83  
ASP HA   H N N 84  
ASP HB2  H N N 85  
ASP HB3  H N N 86  
ASP HD2  H N N 87  
ASP HXT  H N N 88  
CYS N    N N N 89  
CYS CA   C N R 90  
CYS C    C N N 91  
CYS O    O N N 92  
CYS CB   C N N 93  
CYS SG   S N N 94  
CYS OXT  O N N 95  
CYS H    H N N 96  
CYS H2   H N N 97  
CYS HA   H N N 98  
CYS HB2  H N N 99  
CYS HB3  H N N 100 
CYS HG   H N N 101 
CYS HXT  H N N 102 
GLN N    N N N 103 
GLN CA   C N S 104 
GLN C    C N N 105 
GLN O    O N N 106 
GLN CB   C N N 107 
GLN CG   C N N 108 
GLN CD   C N N 109 
GLN OE1  O N N 110 
GLN NE2  N N N 111 
GLN OXT  O N N 112 
GLN H    H N N 113 
GLN H2   H N N 114 
GLN HA   H N N 115 
GLN HB2  H N N 116 
GLN HB3  H N N 117 
GLN HG2  H N N 118 
GLN HG3  H N N 119 
GLN HE21 H N N 120 
GLN HE22 H N N 121 
GLN HXT  H N N 122 
GLU N    N N N 123 
GLU CA   C N S 124 
GLU C    C N N 125 
GLU O    O N N 126 
GLU CB   C N N 127 
GLU CG   C N N 128 
GLU CD   C N N 129 
GLU OE1  O N N 130 
GLU OE2  O N N 131 
GLU OXT  O N N 132 
GLU H    H N N 133 
GLU H2   H N N 134 
GLU HA   H N N 135 
GLU HB2  H N N 136 
GLU HB3  H N N 137 
GLU HG2  H N N 138 
GLU HG3  H N N 139 
GLU HE2  H N N 140 
GLU HXT  H N N 141 
GLY N    N N N 142 
GLY CA   C N N 143 
GLY C    C N N 144 
GLY O    O N N 145 
GLY OXT  O N N 146 
GLY H    H N N 147 
GLY H2   H N N 148 
GLY HA2  H N N 149 
GLY HA3  H N N 150 
GLY HXT  H N N 151 
HIS N    N N N 152 
HIS CA   C N S 153 
HIS C    C N N 154 
HIS O    O N N 155 
HIS CB   C N N 156 
HIS CG   C Y N 157 
HIS ND1  N Y N 158 
HIS CD2  C Y N 159 
HIS CE1  C Y N 160 
HIS NE2  N Y N 161 
HIS OXT  O N N 162 
HIS H    H N N 163 
HIS H2   H N N 164 
HIS HA   H N N 165 
HIS HB2  H N N 166 
HIS HB3  H N N 167 
HIS HD1  H N N 168 
HIS HD2  H N N 169 
HIS HE1  H N N 170 
HIS HE2  H N N 171 
HIS HXT  H N N 172 
HOH O    O N N 173 
HOH H1   H N N 174 
HOH H2   H N N 175 
ILE N    N N N 176 
ILE CA   C N S 177 
ILE C    C N N 178 
ILE O    O N N 179 
ILE CB   C N S 180 
ILE CG1  C N N 181 
ILE CG2  C N N 182 
ILE CD1  C N N 183 
ILE OXT  O N N 184 
ILE H    H N N 185 
ILE H2   H N N 186 
ILE HA   H N N 187 
ILE HB   H N N 188 
ILE HG12 H N N 189 
ILE HG13 H N N 190 
ILE HG21 H N N 191 
ILE HG22 H N N 192 
ILE HG23 H N N 193 
ILE HD11 H N N 194 
ILE HD12 H N N 195 
ILE HD13 H N N 196 
ILE HXT  H N N 197 
LEU N    N N N 198 
LEU CA   C N S 199 
LEU C    C N N 200 
LEU O    O N N 201 
LEU CB   C N N 202 
LEU CG   C N N 203 
LEU CD1  C N N 204 
LEU CD2  C N N 205 
LEU OXT  O N N 206 
LEU H    H N N 207 
LEU H2   H N N 208 
LEU HA   H N N 209 
LEU HB2  H N N 210 
LEU HB3  H N N 211 
LEU HG   H N N 212 
LEU HD11 H N N 213 
LEU HD12 H N N 214 
LEU HD13 H N N 215 
LEU HD21 H N N 216 
LEU HD22 H N N 217 
LEU HD23 H N N 218 
LEU HXT  H N N 219 
LYS N    N N N 220 
LYS CA   C N S 221 
LYS C    C N N 222 
LYS O    O N N 223 
LYS CB   C N N 224 
LYS CG   C N N 225 
LYS CD   C N N 226 
LYS CE   C N N 227 
LYS NZ   N N N 228 
LYS OXT  O N N 229 
LYS H    H N N 230 
LYS H2   H N N 231 
LYS HA   H N N 232 
LYS HB2  H N N 233 
LYS HB3  H N N 234 
LYS HG2  H N N 235 
LYS HG3  H N N 236 
LYS HD2  H N N 237 
LYS HD3  H N N 238 
LYS HE2  H N N 239 
LYS HE3  H N N 240 
LYS HZ1  H N N 241 
LYS HZ2  H N N 242 
LYS HZ3  H N N 243 
LYS HXT  H N N 244 
MET N    N N N 245 
MET CA   C N S 246 
MET C    C N N 247 
MET O    O N N 248 
MET CB   C N N 249 
MET CG   C N N 250 
MET SD   S N N 251 
MET CE   C N N 252 
MET OXT  O N N 253 
MET H    H N N 254 
MET H2   H N N 255 
MET HA   H N N 256 
MET HB2  H N N 257 
MET HB3  H N N 258 
MET HG2  H N N 259 
MET HG3  H N N 260 
MET HE1  H N N 261 
MET HE2  H N N 262 
MET HE3  H N N 263 
MET HXT  H N N 264 
NAD PA   P N S 265 
NAD O1A  O N N 266 
NAD O2A  O N N 267 
NAD O5B  O N N 268 
NAD C5B  C N N 269 
NAD C4B  C N R 270 
NAD O4B  O N N 271 
NAD C3B  C N S 272 
NAD O3B  O N N 273 
NAD C2B  C N R 274 
NAD O2B  O N N 275 
NAD C1B  C N R 276 
NAD N9A  N Y N 277 
NAD C8A  C Y N 278 
NAD N7A  N Y N 279 
NAD C5A  C Y N 280 
NAD C6A  C Y N 281 
NAD N6A  N N N 282 
NAD N1A  N Y N 283 
NAD C2A  C Y N 284 
NAD N3A  N Y N 285 
NAD C4A  C Y N 286 
NAD O3   O N N 287 
NAD PN   P N N 288 
NAD O1N  O N N 289 
NAD O2N  O N N 290 
NAD O5D  O N N 291 
NAD C5D  C N N 292 
NAD C4D  C N R 293 
NAD O4D  O N N 294 
NAD C3D  C N S 295 
NAD O3D  O N N 296 
NAD C2D  C N R 297 
NAD O2D  O N N 298 
NAD C1D  C N R 299 
NAD N1N  N Y N 300 
NAD C2N  C Y N 301 
NAD C3N  C Y N 302 
NAD C7N  C N N 303 
NAD O7N  O N N 304 
NAD N7N  N N N 305 
NAD C4N  C Y N 306 
NAD C5N  C Y N 307 
NAD C6N  C Y N 308 
NAD HOA2 H N N 309 
NAD H51A H N N 310 
NAD H52A H N N 311 
NAD H4B  H N N 312 
NAD H3B  H N N 313 
NAD HO3A H N N 314 
NAD H2B  H N N 315 
NAD HO2A H N N 316 
NAD H1B  H N N 317 
NAD H8A  H N N 318 
NAD H61A H N N 319 
NAD H62A H N N 320 
NAD H2A  H N N 321 
NAD H51N H N N 322 
NAD H52N H N N 323 
NAD H4D  H N N 324 
NAD H3D  H N N 325 
NAD HO3N H N N 326 
NAD H2D  H N N 327 
NAD HO2N H N N 328 
NAD H1D  H N N 329 
NAD H2N  H N N 330 
NAD H71N H N N 331 
NAD H72N H N N 332 
NAD H4N  H N N 333 
NAD H5N  H N N 334 
NAD H6N  H N N 335 
PHE N    N N N 336 
PHE CA   C N S 337 
PHE C    C N N 338 
PHE O    O N N 339 
PHE CB   C N N 340 
PHE CG   C Y N 341 
PHE CD1  C Y N 342 
PHE CD2  C Y N 343 
PHE CE1  C Y N 344 
PHE CE2  C Y N 345 
PHE CZ   C Y N 346 
PHE OXT  O N N 347 
PHE H    H N N 348 
PHE H2   H N N 349 
PHE HA   H N N 350 
PHE HB2  H N N 351 
PHE HB3  H N N 352 
PHE HD1  H N N 353 
PHE HD2  H N N 354 
PHE HE1  H N N 355 
PHE HE2  H N N 356 
PHE HZ   H N N 357 
PHE HXT  H N N 358 
PRO N    N N N 359 
PRO CA   C N S 360 
PRO C    C N N 361 
PRO O    O N N 362 
PRO CB   C N N 363 
PRO CG   C N N 364 
PRO CD   C N N 365 
PRO OXT  O N N 366 
PRO H    H N N 367 
PRO HA   H N N 368 
PRO HB2  H N N 369 
PRO HB3  H N N 370 
PRO HG2  H N N 371 
PRO HG3  H N N 372 
PRO HD2  H N N 373 
PRO HD3  H N N 374 
PRO HXT  H N N 375 
SER N    N N N 376 
SER CA   C N S 377 
SER C    C N N 378 
SER O    O N N 379 
SER CB   C N N 380 
SER OG   O N N 381 
SER OXT  O N N 382 
SER H    H N N 383 
SER H2   H N N 384 
SER HA   H N N 385 
SER HB2  H N N 386 
SER HB3  H N N 387 
SER HG   H N N 388 
SER HXT  H N N 389 
SO4 S    S N N 390 
SO4 O1   O N N 391 
SO4 O2   O N N 392 
SO4 O3   O N N 393 
SO4 O4   O N N 394 
THR N    N N N 395 
THR CA   C N S 396 
THR C    C N N 397 
THR O    O N N 398 
THR CB   C N R 399 
THR OG1  O N N 400 
THR CG2  C N N 401 
THR OXT  O N N 402 
THR H    H N N 403 
THR H2   H N N 404 
THR HA   H N N 405 
THR HB   H N N 406 
THR HG1  H N N 407 
THR HG21 H N N 408 
THR HG22 H N N 409 
THR HG23 H N N 410 
THR HXT  H N N 411 
TRP N    N N N 412 
TRP CA   C N S 413 
TRP C    C N N 414 
TRP O    O N N 415 
TRP CB   C N N 416 
TRP CG   C Y N 417 
TRP CD1  C Y N 418 
TRP CD2  C Y N 419 
TRP NE1  N Y N 420 
TRP CE2  C Y N 421 
TRP CE3  C Y N 422 
TRP CZ2  C Y N 423 
TRP CZ3  C Y N 424 
TRP CH2  C Y N 425 
TRP OXT  O N N 426 
TRP H    H N N 427 
TRP H2   H N N 428 
TRP HA   H N N 429 
TRP HB2  H N N 430 
TRP HB3  H N N 431 
TRP HD1  H N N 432 
TRP HE1  H N N 433 
TRP HE3  H N N 434 
TRP HZ2  H N N 435 
TRP HZ3  H N N 436 
TRP HH2  H N N 437 
TRP HXT  H N N 438 
TYR N    N N N 439 
TYR CA   C N S 440 
TYR C    C N N 441 
TYR O    O N N 442 
TYR CB   C N N 443 
TYR CG   C Y N 444 
TYR CD1  C Y N 445 
TYR CD2  C Y N 446 
TYR CE1  C Y N 447 
TYR CE2  C Y N 448 
TYR CZ   C Y N 449 
TYR OH   O N N 450 
TYR OXT  O N N 451 
TYR H    H N N 452 
TYR H2   H N N 453 
TYR HA   H N N 454 
TYR HB2  H N N 455 
TYR HB3  H N N 456 
TYR HD1  H N N 457 
TYR HD2  H N N 458 
TYR HE1  H N N 459 
TYR HE2  H N N 460 
TYR HH   H N N 461 
TYR HXT  H N N 462 
VAL N    N N N 463 
VAL CA   C N S 464 
VAL C    C N N 465 
VAL O    O N N 466 
VAL CB   C N N 467 
VAL CG1  C N N 468 
VAL CG2  C N N 469 
VAL OXT  O N N 470 
VAL H    H N N 471 
VAL H2   H N N 472 
VAL HA   H N N 473 
VAL HB   H N N 474 
VAL HG11 H N N 475 
VAL HG12 H N N 476 
VAL HG13 H N N 477 
VAL HG21 H N N 478 
VAL HG22 H N N 479 
VAL HG23 H N N 480 
VAL HXT  H N N 481 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ADE N9  C8   sing Y N 1   
ADE N9  C4   sing Y N 2   
ADE N9  HN9  sing N N 3   
ADE C8  N7   doub Y N 4   
ADE C8  H8   sing N N 5   
ADE N7  C5   sing Y N 6   
ADE C5  C6   sing Y N 7   
ADE C5  C4   doub Y N 8   
ADE C6  N6   sing N N 9   
ADE C6  N1   doub Y N 10  
ADE N6  HN61 sing N N 11  
ADE N6  HN62 sing N N 12  
ADE N1  C2   sing Y N 13  
ADE C2  N3   doub Y N 14  
ADE C2  H2   sing N N 15  
ADE N3  C4   sing Y N 16  
ALA N   CA   sing N N 17  
ALA N   H    sing N N 18  
ALA N   H2   sing N N 19  
ALA CA  C    sing N N 20  
ALA CA  CB   sing N N 21  
ALA CA  HA   sing N N 22  
ALA C   O    doub N N 23  
ALA C   OXT  sing N N 24  
ALA CB  HB1  sing N N 25  
ALA CB  HB2  sing N N 26  
ALA CB  HB3  sing N N 27  
ALA OXT HXT  sing N N 28  
ARG N   CA   sing N N 29  
ARG N   H    sing N N 30  
ARG N   H2   sing N N 31  
ARG CA  C    sing N N 32  
ARG CA  CB   sing N N 33  
ARG CA  HA   sing N N 34  
ARG C   O    doub N N 35  
ARG C   OXT  sing N N 36  
ARG CB  CG   sing N N 37  
ARG CB  HB2  sing N N 38  
ARG CB  HB3  sing N N 39  
ARG CG  CD   sing N N 40  
ARG CG  HG2  sing N N 41  
ARG CG  HG3  sing N N 42  
ARG CD  NE   sing N N 43  
ARG CD  HD2  sing N N 44  
ARG CD  HD3  sing N N 45  
ARG NE  CZ   sing N N 46  
ARG NE  HE   sing N N 47  
ARG CZ  NH1  sing N N 48  
ARG CZ  NH2  doub N N 49  
ARG NH1 HH11 sing N N 50  
ARG NH1 HH12 sing N N 51  
ARG NH2 HH21 sing N N 52  
ARG NH2 HH22 sing N N 53  
ARG OXT HXT  sing N N 54  
ASN N   CA   sing N N 55  
ASN N   H    sing N N 56  
ASN N   H2   sing N N 57  
ASN CA  C    sing N N 58  
ASN CA  CB   sing N N 59  
ASN CA  HA   sing N N 60  
ASN C   O    doub N N 61  
ASN C   OXT  sing N N 62  
ASN CB  CG   sing N N 63  
ASN CB  HB2  sing N N 64  
ASN CB  HB3  sing N N 65  
ASN CG  OD1  doub N N 66  
ASN CG  ND2  sing N N 67  
ASN ND2 HD21 sing N N 68  
ASN ND2 HD22 sing N N 69  
ASN OXT HXT  sing N N 70  
ASP N   CA   sing N N 71  
ASP N   H    sing N N 72  
ASP N   H2   sing N N 73  
ASP CA  C    sing N N 74  
ASP CA  CB   sing N N 75  
ASP CA  HA   sing N N 76  
ASP C   O    doub N N 77  
ASP C   OXT  sing N N 78  
ASP CB  CG   sing N N 79  
ASP CB  HB2  sing N N 80  
ASP CB  HB3  sing N N 81  
ASP CG  OD1  doub N N 82  
ASP CG  OD2  sing N N 83  
ASP OD2 HD2  sing N N 84  
ASP OXT HXT  sing N N 85  
CYS N   CA   sing N N 86  
CYS N   H    sing N N 87  
CYS N   H2   sing N N 88  
CYS CA  C    sing N N 89  
CYS CA  CB   sing N N 90  
CYS CA  HA   sing N N 91  
CYS C   O    doub N N 92  
CYS C   OXT  sing N N 93  
CYS CB  SG   sing N N 94  
CYS CB  HB2  sing N N 95  
CYS CB  HB3  sing N N 96  
CYS SG  HG   sing N N 97  
CYS OXT HXT  sing N N 98  
GLN N   CA   sing N N 99  
GLN N   H    sing N N 100 
GLN N   H2   sing N N 101 
GLN CA  C    sing N N 102 
GLN CA  CB   sing N N 103 
GLN CA  HA   sing N N 104 
GLN C   O    doub N N 105 
GLN C   OXT  sing N N 106 
GLN CB  CG   sing N N 107 
GLN CB  HB2  sing N N 108 
GLN CB  HB3  sing N N 109 
GLN CG  CD   sing N N 110 
GLN CG  HG2  sing N N 111 
GLN CG  HG3  sing N N 112 
GLN CD  OE1  doub N N 113 
GLN CD  NE2  sing N N 114 
GLN NE2 HE21 sing N N 115 
GLN NE2 HE22 sing N N 116 
GLN OXT HXT  sing N N 117 
GLU N   CA   sing N N 118 
GLU N   H    sing N N 119 
GLU N   H2   sing N N 120 
GLU CA  C    sing N N 121 
GLU CA  CB   sing N N 122 
GLU CA  HA   sing N N 123 
GLU C   O    doub N N 124 
GLU C   OXT  sing N N 125 
GLU CB  CG   sing N N 126 
GLU CB  HB2  sing N N 127 
GLU CB  HB3  sing N N 128 
GLU CG  CD   sing N N 129 
GLU CG  HG2  sing N N 130 
GLU CG  HG3  sing N N 131 
GLU CD  OE1  doub N N 132 
GLU CD  OE2  sing N N 133 
GLU OE2 HE2  sing N N 134 
GLU OXT HXT  sing N N 135 
GLY N   CA   sing N N 136 
GLY N   H    sing N N 137 
GLY N   H2   sing N N 138 
GLY CA  C    sing N N 139 
GLY CA  HA2  sing N N 140 
GLY CA  HA3  sing N N 141 
GLY C   O    doub N N 142 
GLY C   OXT  sing N N 143 
GLY OXT HXT  sing N N 144 
HIS N   CA   sing N N 145 
HIS N   H    sing N N 146 
HIS N   H2   sing N N 147 
HIS CA  C    sing N N 148 
HIS CA  CB   sing N N 149 
HIS CA  HA   sing N N 150 
HIS C   O    doub N N 151 
HIS C   OXT  sing N N 152 
HIS CB  CG   sing N N 153 
HIS CB  HB2  sing N N 154 
HIS CB  HB3  sing N N 155 
HIS CG  ND1  sing Y N 156 
HIS CG  CD2  doub Y N 157 
HIS ND1 CE1  doub Y N 158 
HIS ND1 HD1  sing N N 159 
HIS CD2 NE2  sing Y N 160 
HIS CD2 HD2  sing N N 161 
HIS CE1 NE2  sing Y N 162 
HIS CE1 HE1  sing N N 163 
HIS NE2 HE2  sing N N 164 
HIS OXT HXT  sing N N 165 
HOH O   H1   sing N N 166 
HOH O   H2   sing N N 167 
ILE N   CA   sing N N 168 
ILE N   H    sing N N 169 
ILE N   H2   sing N N 170 
ILE CA  C    sing N N 171 
ILE CA  CB   sing N N 172 
ILE CA  HA   sing N N 173 
ILE C   O    doub N N 174 
ILE C   OXT  sing N N 175 
ILE CB  CG1  sing N N 176 
ILE CB  CG2  sing N N 177 
ILE CB  HB   sing N N 178 
ILE CG1 CD1  sing N N 179 
ILE CG1 HG12 sing N N 180 
ILE CG1 HG13 sing N N 181 
ILE CG2 HG21 sing N N 182 
ILE CG2 HG22 sing N N 183 
ILE CG2 HG23 sing N N 184 
ILE CD1 HD11 sing N N 185 
ILE CD1 HD12 sing N N 186 
ILE CD1 HD13 sing N N 187 
ILE OXT HXT  sing N N 188 
LEU N   CA   sing N N 189 
LEU N   H    sing N N 190 
LEU N   H2   sing N N 191 
LEU CA  C    sing N N 192 
LEU CA  CB   sing N N 193 
LEU CA  HA   sing N N 194 
LEU C   O    doub N N 195 
LEU C   OXT  sing N N 196 
LEU CB  CG   sing N N 197 
LEU CB  HB2  sing N N 198 
LEU CB  HB3  sing N N 199 
LEU CG  CD1  sing N N 200 
LEU CG  CD2  sing N N 201 
LEU CG  HG   sing N N 202 
LEU CD1 HD11 sing N N 203 
LEU CD1 HD12 sing N N 204 
LEU CD1 HD13 sing N N 205 
LEU CD2 HD21 sing N N 206 
LEU CD2 HD22 sing N N 207 
LEU CD2 HD23 sing N N 208 
LEU OXT HXT  sing N N 209 
LYS N   CA   sing N N 210 
LYS N   H    sing N N 211 
LYS N   H2   sing N N 212 
LYS CA  C    sing N N 213 
LYS CA  CB   sing N N 214 
LYS CA  HA   sing N N 215 
LYS C   O    doub N N 216 
LYS C   OXT  sing N N 217 
LYS CB  CG   sing N N 218 
LYS CB  HB2  sing N N 219 
LYS CB  HB3  sing N N 220 
LYS CG  CD   sing N N 221 
LYS CG  HG2  sing N N 222 
LYS CG  HG3  sing N N 223 
LYS CD  CE   sing N N 224 
LYS CD  HD2  sing N N 225 
LYS CD  HD3  sing N N 226 
LYS CE  NZ   sing N N 227 
LYS CE  HE2  sing N N 228 
LYS CE  HE3  sing N N 229 
LYS NZ  HZ1  sing N N 230 
LYS NZ  HZ2  sing N N 231 
LYS NZ  HZ3  sing N N 232 
LYS OXT HXT  sing N N 233 
MET N   CA   sing N N 234 
MET N   H    sing N N 235 
MET N   H2   sing N N 236 
MET CA  C    sing N N 237 
MET CA  CB   sing N N 238 
MET CA  HA   sing N N 239 
MET C   O    doub N N 240 
MET C   OXT  sing N N 241 
MET CB  CG   sing N N 242 
MET CB  HB2  sing N N 243 
MET CB  HB3  sing N N 244 
MET CG  SD   sing N N 245 
MET CG  HG2  sing N N 246 
MET CG  HG3  sing N N 247 
MET SD  CE   sing N N 248 
MET CE  HE1  sing N N 249 
MET CE  HE2  sing N N 250 
MET CE  HE3  sing N N 251 
MET OXT HXT  sing N N 252 
NAD PA  O1A  doub N N 253 
NAD PA  O2A  sing N N 254 
NAD PA  O5B  sing N N 255 
NAD PA  O3   sing N N 256 
NAD O2A HOA2 sing N N 257 
NAD O5B C5B  sing N N 258 
NAD C5B C4B  sing N N 259 
NAD C5B H51A sing N N 260 
NAD C5B H52A sing N N 261 
NAD C4B O4B  sing N N 262 
NAD C4B C3B  sing N N 263 
NAD C4B H4B  sing N N 264 
NAD O4B C1B  sing N N 265 
NAD C3B O3B  sing N N 266 
NAD C3B C2B  sing N N 267 
NAD C3B H3B  sing N N 268 
NAD O3B HO3A sing N N 269 
NAD C2B O2B  sing N N 270 
NAD C2B C1B  sing N N 271 
NAD C2B H2B  sing N N 272 
NAD O2B HO2A sing N N 273 
NAD C1B N9A  sing N N 274 
NAD C1B H1B  sing N N 275 
NAD N9A C8A  sing Y N 276 
NAD N9A C4A  sing Y N 277 
NAD C8A N7A  doub Y N 278 
NAD C8A H8A  sing N N 279 
NAD N7A C5A  sing Y N 280 
NAD C5A C6A  sing Y N 281 
NAD C5A C4A  doub Y N 282 
NAD C6A N6A  sing N N 283 
NAD C6A N1A  doub Y N 284 
NAD N6A H61A sing N N 285 
NAD N6A H62A sing N N 286 
NAD N1A C2A  sing Y N 287 
NAD C2A N3A  doub Y N 288 
NAD C2A H2A  sing N N 289 
NAD N3A C4A  sing Y N 290 
NAD O3  PN   sing N N 291 
NAD PN  O1N  doub N N 292 
NAD PN  O2N  sing N N 293 
NAD PN  O5D  sing N N 294 
NAD O5D C5D  sing N N 295 
NAD C5D C4D  sing N N 296 
NAD C5D H51N sing N N 297 
NAD C5D H52N sing N N 298 
NAD C4D O4D  sing N N 299 
NAD C4D C3D  sing N N 300 
NAD C4D H4D  sing N N 301 
NAD O4D C1D  sing N N 302 
NAD C3D O3D  sing N N 303 
NAD C3D C2D  sing N N 304 
NAD C3D H3D  sing N N 305 
NAD O3D HO3N sing N N 306 
NAD C2D O2D  sing N N 307 
NAD C2D C1D  sing N N 308 
NAD C2D H2D  sing N N 309 
NAD O2D HO2N sing N N 310 
NAD C1D N1N  sing N N 311 
NAD C1D H1D  sing N N 312 
NAD N1N C2N  sing Y N 313 
NAD N1N C6N  doub Y N 314 
NAD C2N C3N  doub Y N 315 
NAD C2N H2N  sing N N 316 
NAD C3N C7N  sing N N 317 
NAD C3N C4N  sing Y N 318 
NAD C7N O7N  doub N N 319 
NAD C7N N7N  sing N N 320 
NAD N7N H71N sing N N 321 
NAD N7N H72N sing N N 322 
NAD C4N C5N  doub Y N 323 
NAD C4N H4N  sing N N 324 
NAD C5N C6N  sing Y N 325 
NAD C5N H5N  sing N N 326 
NAD C6N H6N  sing N N 327 
PHE N   CA   sing N N 328 
PHE N   H    sing N N 329 
PHE N   H2   sing N N 330 
PHE CA  C    sing N N 331 
PHE CA  CB   sing N N 332 
PHE CA  HA   sing N N 333 
PHE C   O    doub N N 334 
PHE C   OXT  sing N N 335 
PHE CB  CG   sing N N 336 
PHE CB  HB2  sing N N 337 
PHE CB  HB3  sing N N 338 
PHE CG  CD1  doub Y N 339 
PHE CG  CD2  sing Y N 340 
PHE CD1 CE1  sing Y N 341 
PHE CD1 HD1  sing N N 342 
PHE CD2 CE2  doub Y N 343 
PHE CD2 HD2  sing N N 344 
PHE CE1 CZ   doub Y N 345 
PHE CE1 HE1  sing N N 346 
PHE CE2 CZ   sing Y N 347 
PHE CE2 HE2  sing N N 348 
PHE CZ  HZ   sing N N 349 
PHE OXT HXT  sing N N 350 
PRO N   CA   sing N N 351 
PRO N   CD   sing N N 352 
PRO N   H    sing N N 353 
PRO CA  C    sing N N 354 
PRO CA  CB   sing N N 355 
PRO CA  HA   sing N N 356 
PRO C   O    doub N N 357 
PRO C   OXT  sing N N 358 
PRO CB  CG   sing N N 359 
PRO CB  HB2  sing N N 360 
PRO CB  HB3  sing N N 361 
PRO CG  CD   sing N N 362 
PRO CG  HG2  sing N N 363 
PRO CG  HG3  sing N N 364 
PRO CD  HD2  sing N N 365 
PRO CD  HD3  sing N N 366 
PRO OXT HXT  sing N N 367 
SER N   CA   sing N N 368 
SER N   H    sing N N 369 
SER N   H2   sing N N 370 
SER CA  C    sing N N 371 
SER CA  CB   sing N N 372 
SER CA  HA   sing N N 373 
SER C   O    doub N N 374 
SER C   OXT  sing N N 375 
SER CB  OG   sing N N 376 
SER CB  HB2  sing N N 377 
SER CB  HB3  sing N N 378 
SER OG  HG   sing N N 379 
SER OXT HXT  sing N N 380 
SO4 S   O1   doub N N 381 
SO4 S   O2   doub N N 382 
SO4 S   O3   sing N N 383 
SO4 S   O4   sing N N 384 
THR N   CA   sing N N 385 
THR N   H    sing N N 386 
THR N   H2   sing N N 387 
THR CA  C    sing N N 388 
THR CA  CB   sing N N 389 
THR CA  HA   sing N N 390 
THR C   O    doub N N 391 
THR C   OXT  sing N N 392 
THR CB  OG1  sing N N 393 
THR CB  CG2  sing N N 394 
THR CB  HB   sing N N 395 
THR OG1 HG1  sing N N 396 
THR CG2 HG21 sing N N 397 
THR CG2 HG22 sing N N 398 
THR CG2 HG23 sing N N 399 
THR OXT HXT  sing N N 400 
TRP N   CA   sing N N 401 
TRP N   H    sing N N 402 
TRP N   H2   sing N N 403 
TRP CA  C    sing N N 404 
TRP CA  CB   sing N N 405 
TRP CA  HA   sing N N 406 
TRP C   O    doub N N 407 
TRP C   OXT  sing N N 408 
TRP CB  CG   sing N N 409 
TRP CB  HB2  sing N N 410 
TRP CB  HB3  sing N N 411 
TRP CG  CD1  doub Y N 412 
TRP CG  CD2  sing Y N 413 
TRP CD1 NE1  sing Y N 414 
TRP CD1 HD1  sing N N 415 
TRP CD2 CE2  doub Y N 416 
TRP CD2 CE3  sing Y N 417 
TRP NE1 CE2  sing Y N 418 
TRP NE1 HE1  sing N N 419 
TRP CE2 CZ2  sing Y N 420 
TRP CE3 CZ3  doub Y N 421 
TRP CE3 HE3  sing N N 422 
TRP CZ2 CH2  doub Y N 423 
TRP CZ2 HZ2  sing N N 424 
TRP CZ3 CH2  sing Y N 425 
TRP CZ3 HZ3  sing N N 426 
TRP CH2 HH2  sing N N 427 
TRP OXT HXT  sing N N 428 
TYR N   CA   sing N N 429 
TYR N   H    sing N N 430 
TYR N   H2   sing N N 431 
TYR CA  C    sing N N 432 
TYR CA  CB   sing N N 433 
TYR CA  HA   sing N N 434 
TYR C   O    doub N N 435 
TYR C   OXT  sing N N 436 
TYR CB  CG   sing N N 437 
TYR CB  HB2  sing N N 438 
TYR CB  HB3  sing N N 439 
TYR CG  CD1  doub Y N 440 
TYR CG  CD2  sing Y N 441 
TYR CD1 CE1  sing Y N 442 
TYR CD1 HD1  sing N N 443 
TYR CD2 CE2  doub Y N 444 
TYR CD2 HD2  sing N N 445 
TYR CE1 CZ   doub Y N 446 
TYR CE1 HE1  sing N N 447 
TYR CE2 CZ   sing Y N 448 
TYR CE2 HE2  sing N N 449 
TYR CZ  OH   sing N N 450 
TYR OH  HH   sing N N 451 
TYR OXT HXT  sing N N 452 
VAL N   CA   sing N N 453 
VAL N   H    sing N N 454 
VAL N   H2   sing N N 455 
VAL CA  C    sing N N 456 
VAL CA  CB   sing N N 457 
VAL CA  HA   sing N N 458 
VAL C   O    doub N N 459 
VAL C   OXT  sing N N 460 
VAL CB  CG1  sing N N 461 
VAL CB  CG2  sing N N 462 
VAL CB  HB   sing N N 463 
VAL CG1 HG11 sing N N 464 
VAL CG1 HG12 sing N N 465 
VAL CG1 HG13 sing N N 466 
VAL CG2 HG21 sing N N 467 
VAL CG2 HG22 sing N N 468 
VAL CG2 HG23 sing N N 469 
VAL OXT HXT  sing N N 470 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Natural Science Foundation of China (NSFC)' China 32370196 1 
'National Natural Science Foundation of China (NSFC)' China 32071215 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             other 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          Q5ZTY7 
# 
_atom_sites.entry_id                    8WZ9 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.007644 
_atom_sites.fract_transf_matrix[1][2]   0.004413 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008827 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008538 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P 15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.2732   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0555   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . GLN A 1 11  ? 15.226  -12.312 -4.298  1.000 65.410 0 15   GLN A N   1 ? 
ATOM   2    C CA  . GLN A 1 11  ? 15.901  -13.413 -3.616  1.000 61.399 0 15   GLN A CA  1 ? 
ATOM   3    C C   . GLN A 1 11  ? 15.725  -14.724 -4.369  1.000 52.151 0 15   GLN A C   1 ? 
ATOM   4    O O   . GLN A 1 11  ? 14.653  -15.331 -4.345  1.000 47.148 0 15   GLN A O   1 ? 
ATOM   5    C CB  . GLN A 1 11  ? 15.381  -13.565 -2.189  1.000 67.390 0 15   GLN A CB  1 ? 
ATOM   6    C CG  . GLN A 1 11  ? 15.843  -12.477 -1.245  1.000 72.867 0 15   GLN A CG  1 ? 
ATOM   7    C CD  . GLN A 1 11  ? 14.918  -12.320 -0.058  1.000 78.570 0 15   GLN A CD  1 ? 
ATOM   8    O OE1 . GLN A 1 11  ? 14.031  -13.145 0.164   1.000 78.723 0 15   GLN A OE1 1 ? 
ATOM   9    N NE2 . GLN A 1 11  ? 15.117  -11.256 0.712   1.000 82.123 0 15   GLN A NE2 1 ? 
ATOM   10   N N   . ASP A 1 12  ? 16.793  -15.156 -5.032  1.000 47.608 0 16   ASP A N   1 ? 
ATOM   11   C CA  . ASP A 1 12  ? 16.779  -16.391 -5.814  1.000 41.089 0 16   ASP A CA  1 ? 
ATOM   12   C C   . ASP A 1 12  ? 17.137  -17.583 -4.923  1.000 38.084 0 16   ASP A C   1 ? 
ATOM   13   O O   . ASP A 1 12  ? 18.125  -18.286 -5.129  1.000 39.321 0 16   ASP A O   1 ? 
ATOM   14   C CB  . ASP A 1 12  ? 17.729  -16.265 -6.999  1.000 37.778 0 16   ASP A CB  1 ? 
ATOM   15   C CG  . ASP A 1 12  ? 17.573  -17.393 -7.996  1.000 41.105 0 16   ASP A CG  1 ? 
ATOM   16   O OD1 . ASP A 1 12  ? 16.503  -18.044 -8.004  1.000 42.916 0 16   ASP A OD1 1 ? 
ATOM   17   O OD2 . ASP A 1 12  ? 18.529  -17.632 -8.761  1.000 36.868 0 16   ASP A OD2 1 ? 
ATOM   18   N N   . TYR A 1 13  ? 16.304  -17.786 -3.906  1.000 36.581 0 17   TYR A N   1 ? 
ATOM   19   C CA  . TYR A 1 13  ? 16.452  -18.890 -2.965  1.000 37.178 0 17   TYR A CA  1 ? 
ATOM   20   C C   . TYR A 1 13  ? 15.166  -18.975 -2.156  1.000 34.996 0 17   TYR A C   1 ? 
ATOM   21   O O   . TYR A 1 13  ? 14.319  -18.081 -2.213  1.000 35.783 0 17   TYR A O   1 ? 
ATOM   22   C CB  . TYR A 1 13  ? 17.675  -18.703 -2.052  1.000 38.457 0 17   TYR A CB  1 ? 
ATOM   23   C CG  . TYR A 1 13  ? 17.614  -17.498 -1.124  1.000 40.247 0 17   TYR A CG  1 ? 
ATOM   24   C CD1 . TYR A 1 13  ? 16.847  -17.524 0.036   1.000 40.418 0 17   TYR A CD1 1 ? 
ATOM   25   C CD2 . TYR A 1 13  ? 18.338  -16.344 -1.399  1.000 44.553 0 17   TYR A CD2 1 ? 
ATOM   26   C CE1 . TYR A 1 13  ? 16.789  -16.434 0.887   1.000 44.919 0 17   TYR A CE1 1 ? 
ATOM   27   C CE2 . TYR A 1 13  ? 18.288  -15.247 -0.550  1.000 44.129 0 17   TYR A CE2 1 ? 
ATOM   28   C CZ  . TYR A 1 13  ? 17.512  -15.299 0.590   1.000 47.619 0 17   TYR A CZ  1 ? 
ATOM   29   O OH  . TYR A 1 13  ? 17.453  -14.215 1.442   1.000 52.551 0 17   TYR A OH  1 ? 
ATOM   30   N N   . LYS A 1 14  ? 15.027  -20.057 -1.394  1.000 35.041 0 18   LYS A N   1 ? 
ATOM   31   C CA  . LYS A 1 14  ? 13.939  -20.146 -0.423  1.000 34.944 0 18   LYS A CA  1 ? 
ATOM   32   C C   . LYS A 1 14  ? 14.406  -21.033 0.719   1.000 34.944 0 18   LYS A C   1 ? 
ATOM   33   O O   . LYS A 1 14  ? 14.656  -22.227 0.514   1.000 32.609 0 18   LYS A O   1 ? 
ATOM   34   C CB  . LYS A 1 14  ? 12.660  -20.690 -1.052  1.000 37.944 0 18   LYS A CB  1 ? 
ATOM   35   C CG  . LYS A 1 14  ? 11.458  -20.584 -0.130  1.000 44.384 0 18   LYS A CG  1 ? 
ATOM   36   C CD  . LYS A 1 14  ? 10.163  -20.925 -0.847  1.000 52.477 0 18   LYS A CD  1 ? 
ATOM   37   C CE  . LYS A 1 14  ? 8.980   -20.906 0.111   1.000 59.605 0 18   LYS A CE  1 ? 
ATOM   38   N NZ  . LYS A 1 14  ? 9.055   -19.756 1.055   1.000 64.845 0 18   LYS A NZ  1 ? 
ATOM   39   N N   . VAL A 1 15  ? 14.537  -20.447 1.910   1.000 33.543 0 19   VAL A N   1 ? 
ATOM   40   C CA  . VAL A 1 15  ? 14.968  -21.157 3.108   1.000 32.407 0 19   VAL A CA  1 ? 
ATOM   41   C C   . VAL A 1 15  ? 14.082  -20.722 4.271   1.000 31.559 0 19   VAL A C   1 ? 
ATOM   42   O O   . VAL A 1 15  ? 13.327  -19.752 4.182   1.000 33.917 0 19   VAL A O   1 ? 
ATOM   43   C CB  . VAL A 1 15  ? 16.456  -20.905 3.441   1.000 32.593 0 19   VAL A CB  1 ? 
ATOM   44   C CG1 . VAL A 1 15  ? 17.360  -21.359 2.284   1.000 31.333 0 19   VAL A CG1 1 ? 
ATOM   45   C CG2 . VAL A 1 15  ? 16.685  -19.442 3.762   1.000 34.530 0 19   VAL A CG2 1 ? 
ATOM   46   N N   . ALA A 1 16  ? 14.194  -21.451 5.383   1.000 31.585 0 20   ALA A N   1 ? 
ATOM   47   C CA  . ALA A 1 16  ? 13.333  -21.184 6.532   1.000 31.430 0 20   ALA A CA  1 ? 
ATOM   48   C C   . ALA A 1 16  ? 13.674  -19.854 7.198   1.000 36.328 0 20   ALA A C   1 ? 
ATOM   49   O O   . ALA A 1 16  ? 12.777  -19.064 7.518   1.000 38.307 0 20   ALA A O   1 ? 
ATOM   50   C CB  . ALA A 1 16  ? 13.440  -22.328 7.543   1.000 32.180 0 20   ALA A CB  1 ? 
ATOM   51   N N   . GLU A 1 17  ? 14.962  -19.593 7.436   1.000 35.862 0 21   GLU A N   1 ? 
ATOM   52   C CA  . GLU A 1 17  ? 15.350  -18.420 8.221   1.000 41.439 0 21   GLU A CA  1 ? 
ATOM   53   C C   . GLU A 1 17  ? 16.798  -18.072 7.876   1.000 39.642 0 21   GLU A C   1 ? 
ATOM   54   O O   . GLU A 1 17  ? 17.723  -18.748 8.335   1.000 36.910 0 21   GLU A O   1 ? 
ATOM   55   C CB  . GLU A 1 17  ? 15.178  -18.681 9.711   1.000 45.105 0 21   GLU A CB  1 ? 
ATOM   56   C CG  . GLU A 1 17  ? 15.427  -17.462 10.587  1.000 54.499 0 21   GLU A CG  1 ? 
ATOM   57   C CD  . GLU A 1 17  ? 14.829  -16.184 10.006  1.000 65.826 0 21   GLU A CD  1 ? 
ATOM   58   O OE1 . GLU A 1 17  ? 13.582  -16.079 9.956   1.000 69.393 0 21   GLU A OE1 1 ? 
ATOM   59   O OE2 . GLU A 1 17  ? 15.603  -15.283 9.602   1.000 63.668 0 21   GLU A OE2 1 ? 
ATOM   60   N N   . ILE A 1 18  ? 16.979  -17.005 7.093   1.000 39.318 0 22   ILE A N   1 ? 
ATOM   61   C CA  . ILE A 1 18  ? 18.308  -16.631 6.622   1.000 37.860 0 22   ILE A CA  1 ? 
ATOM   62   C C   . ILE A 1 18  ? 19.239  -16.252 7.769   1.000 39.039 0 22   ILE A C   1 ? 
ATOM   63   O O   . ILE A 1 18  ? 20.460  -16.370 7.634   1.000 39.652 0 22   ILE A O   1 ? 
ATOM   64   C CB  . ILE A 1 18  ? 18.195  -15.488 5.587   1.000 39.960 0 22   ILE A CB  1 ? 
ATOM   65   C CG1 . ILE A 1 18  ? 19.531  -15.256 4.871   1.000 46.377 0 22   ILE A CG1 1 ? 
ATOM   66   C CG2 . ILE A 1 18  ? 17.714  -14.204 6.254   1.000 41.658 0 22   ILE A CG2 1 ? 
ATOM   67   C CD1 . ILE A 1 18  ? 19.880  -16.312 3.829   1.000 45.819 0 22   ILE A CD1 1 ? 
ATOM   68   N N   . SER A 1 19  ? 18.695  -15.815 8.909   1.000 37.736 0 23   SER A N   1 ? 
ATOM   69   C CA  . SER A 1 19  ? 19.536  -15.407 10.031  1.000 36.610 0 23   SER A CA  1 ? 
ATOM   70   C C   . SER A 1 19  ? 20.269  -16.573 10.685  1.000 38.905 0 23   SER A C   1 ? 
ATOM   71   O O   . SER A 1 19  ? 21.128  -16.340 11.543  1.000 38.544 0 23   SER A O   1 ? 
ATOM   72   C CB  . SER A 1 19  ? 18.698  -14.681 11.082  1.000 41.026 0 23   SER A CB  1 ? 
ATOM   73   O OG  . SER A 1 19  ? 17.721  -15.539 11.641  1.000 45.395 0 23   SER A OG  1 ? 
ATOM   74   N N   . LEU A 1 20  ? 19.955  -17.811 10.315  1.000 35.470 0 24   LEU A N   1 ? 
ATOM   75   C CA  . LEU A 1 20  ? 20.709  -18.953 10.816  1.000 32.849 0 24   LEU A CA  1 ? 
ATOM   76   C C   . LEU A 1 20  ? 22.054  -19.122 10.121  1.000 31.785 0 24   LEU A C   1 ? 
ATOM   77   O O   . LEU A 1 20  ? 22.803  -20.043 10.473  1.000 30.459 0 24   LEU A O   1 ? 
ATOM   78   C CB  . LEU A 1 20  ? 19.894  -20.237 10.659  1.000 36.591 0 24   LEU A CB  1 ? 
ATOM   79   C CG  . LEU A 1 20  ? 18.543  -20.291 11.372  1.000 38.362 0 24   LEU A CG  1 ? 
ATOM   80   C CD1 . LEU A 1 20  ? 17.777  -21.522 10.919  1.000 32.370 0 24   LEU A CD1 1 ? 
ATOM   81   C CD2 . LEU A 1 20  ? 18.734  -20.291 12.882  1.000 41.021 0 24   LEU A CD2 1 ? 
ATOM   82   N N   . ALA A 1 21  ? 22.388  -18.240 9.173   1.000 31.606 0 25   ALA A N   1 ? 
ATOM   83   C CA  . ALA A 1 21  ? 23.557  -18.457 8.326   1.000 33.867 0 25   ALA A CA  1 ? 
ATOM   84   C C   . ALA A 1 21  ? 24.854  -18.444 9.128   1.000 34.054 0 25   ALA A C   1 ? 
ATOM   85   O O   . ALA A 1 21  ? 25.788  -19.189 8.811   1.000 33.072 0 25   ALA A O   1 ? 
ATOM   86   C CB  . ALA A 1 21  ? 23.605  -17.402 7.217   1.000 34.151 0 25   ALA A CB  1 ? 
ATOM   87   N N   . ASP A 1 22  ? 24.939  -17.603 10.165  1.000 31.959 0 26   ASP A N   1 ? 
ATOM   88   C CA  . ASP A 1 22  ? 26.180  -17.516 10.933  1.000 34.270 0 26   ASP A CA  1 ? 
ATOM   89   C C   . ASP A 1 22  ? 26.470  -18.822 11.660  1.000 35.660 0 26   ASP A C   1 ? 
ATOM   90   O O   . ASP A 1 22  ? 27.615  -19.299 11.676  1.000 33.309 0 26   ASP A O   1 ? 
ATOM   91   C CB  . ASP A 1 22  ? 26.109  -16.355 11.927  1.000 42.463 0 26   ASP A CB  1 ? 
ATOM   92   C CG  . ASP A 1 22  ? 27.422  -16.139 12.664  1.000 66.045 0 26   ASP A CG  1 ? 
ATOM   93   O OD1 . ASP A 1 22  ? 28.476  -16.058 11.996  1.000 74.841 0 26   ASP A OD1 1 ? 
ATOM   94   O OD2 . ASP A 1 22  ? 27.402  -16.055 13.912  1.000 74.512 0 26   ASP A OD2 1 ? 
ATOM   95   N N   . TRP A 1 23  ? 25.442  -19.405 12.275  1.000 31.399 0 27   TRP A N   1 ? 
ATOM   96   C CA  . TRP A 1 23  ? 25.571  -20.735 12.858  1.000 30.396 0 27   TRP A CA  1 ? 
ATOM   97   C C   . TRP A 1 23  ? 26.012  -21.751 11.809  1.000 30.496 0 27   TRP A C   1 ? 
ATOM   98   O O   . TRP A 1 23  ? 26.913  -22.564 12.059  1.000 29.301 0 27   TRP A O   1 ? 
ATOM   99   C CB  . TRP A 1 23  ? 24.234  -21.125 13.492  1.000 28.330 0 27   TRP A CB  1 ? 
ATOM   100  C CG  . TRP A 1 23  ? 24.140  -22.524 14.025  1.000 30.048 0 27   TRP A CG  1 ? 
ATOM   101  C CD1 . TRP A 1 23  ? 25.168  -23.343 14.410  1.000 29.511 0 27   TRP A CD1 1 ? 
ATOM   102  C CD2 . TRP A 1 23  ? 22.938  -23.264 14.234  1.000 30.043 0 27   TRP A CD2 1 ? 
ATOM   103  N NE1 . TRP A 1 23  ? 24.671  -24.554 14.843  1.000 30.333 0 27   TRP A NE1 1 ? 
ATOM   104  C CE2 . TRP A 1 23  ? 23.305  -24.529 14.743  1.000 29.277 0 27   TRP A CE2 1 ? 
ATOM   105  C CE3 . TRP A 1 23  ? 21.581  -22.981 14.039  1.000 31.767 0 27   TRP A CE3 1 ? 
ATOM   106  C CZ2 . TRP A 1 23  ? 22.365  -25.505 15.058  1.000 32.720 0 27   TRP A CZ2 1 ? 
ATOM   107  C CZ3 . TRP A 1 23  ? 20.649  -23.953 14.353  1.000 32.278 0 27   TRP A CZ3 1 ? 
ATOM   108  C CH2 . TRP A 1 23  ? 21.043  -25.198 14.858  1.000 34.278 0 27   TRP A CH2 1 ? 
ATOM   109  N N   . GLY A 1 24  ? 25.407  -21.703 10.619  1.000 30.812 0 28   GLY A N   1 ? 
ATOM   110  C CA  . GLY A 1 24  ? 25.805  -22.625 9.563   1.000 27.630 0 28   GLY A CA  1 ? 
ATOM   111  C C   . GLY A 1 24  ? 27.261  -22.462 9.172   1.000 27.214 0 28   GLY A C   1 ? 
ATOM   112  O O   . GLY A 1 24  ? 27.985  -23.449 9.012   1.000 27.903 0 28   GLY A O   1 ? 
ATOM   113  N N   . ARG A 1 25  ? 27.718  -21.211 9.034   1.000 30.035 0 29   ARG A N   1 ? 
ATOM   114  C CA  . ARG A 1 25  ? 29.119  -20.977 8.697   1.000 27.840 0 29   ARG A CA  1 ? 
ATOM   115  C C   . ARG A 1 25  ? 30.043  -21.543 9.768   1.000 30.796 0 29   ARG A C   1 ? 
ATOM   116  O O   . ARG A 1 25  ? 31.093  -22.117 9.453   1.000 29.027 0 29   ARG A O   1 ? 
ATOM   117  C CB  . ARG A 1 25  ? 29.381  -19.478 8.508   1.000 30.314 0 29   ARG A CB  1 ? 
ATOM   118  C CG  . ARG A 1 25  ? 28.958  -18.935 7.149   1.000 44.742 0 29   ARG A CG  1 ? 
ATOM   119  C CD  . ARG A 1 25  ? 29.419  -17.488 6.939   1.000 51.485 0 29   ARG A CD  1 ? 
ATOM   120  N NE  . ARG A 1 25  ? 28.879  -16.574 7.944   1.000 53.438 0 29   ARG A NE  1 ? 
ATOM   121  C CZ  . ARG A 1 25  ? 27.710  -15.948 7.839   1.000 54.959 0 29   ARG A CZ  1 ? 
ATOM   122  N NH1 . ARG A 1 25  ? 26.947  -16.135 6.768   1.000 51.827 0 29   ARG A NH1 1 ? 
ATOM   123  N NH2 . ARG A 1 25  ? 27.301  -15.135 8.805   1.000 55.070 0 29   ARG A NH2 1 ? 
ATOM   124  N N   . LYS A 1 26  ? 29.674  -21.393 11.042  1.000 29.556 0 30   LYS A N   1 ? 
ATOM   125  C CA  . LYS A 1 26  ? 30.526  -21.913 12.108  1.000 31.441 0 30   LYS A CA  1 ? 
ATOM   126  C C   . LYS A 1 26  ? 30.666  -23.427 12.013  1.000 27.111 0 30   LYS A C   1 ? 
ATOM   127  O O   . LYS A 1 26  ? 31.769  -23.966 12.173  1.000 26.848 0 30   LYS A O   1 ? 
ATOM   128  C CB  . LYS A 1 26  ? 29.973  -21.511 13.478  1.000 29.538 0 30   LYS A CB  1 ? 
ATOM   129  C CG  . LYS A 1 26  ? 30.217  -20.045 13.864  1.000 32.733 0 30   LYS A CG  1 ? 
ATOM   130  C CD  . LYS A 1 26  ? 29.464  -19.715 15.144  1.000 36.060 0 30   LYS A CD  1 ? 
ATOM   131  C CE  . LYS A 1 26  ? 29.699  -18.280 15.596  1.000 41.036 0 30   LYS A CE  1 ? 
ATOM   132  N NZ  . LYS A 1 26  ? 29.003  -17.993 16.890  1.000 39.402 0 30   LYS A NZ  1 ? 
ATOM   133  N N   . GLU A 1 27  ? 29.568  -24.132 11.739  1.000 24.724 0 31   GLU A N   1 ? 
ATOM   134  C CA  . GLU A 1 27  ? 29.656  -25.584 11.649  1.000 24.398 0 31   GLU A CA  1 ? 
ATOM   135  C C   . GLU A 1 27  ? 30.275  -26.037 10.333  1.000 27.027 0 31   GLU A C   1 ? 
ATOM   136  O O   . GLU A 1 27  ? 30.915  -27.091 10.288  1.000 26.003 0 31   GLU A O   1 ? 
ATOM   137  C CB  . GLU A 1 27  ? 28.277  -26.206 11.860  1.000 27.166 0 31   GLU A CB  1 ? 
ATOM   138  C CG  . GLU A 1 27  ? 27.812  -26.047 13.311  1.000 28.567 0 31   GLU A CG  1 ? 
ATOM   139  C CD  . GLU A 1 27  ? 26.643  -26.944 13.679  1.000 29.651 0 31   GLU A CD  1 ? 
ATOM   140  O OE1 . GLU A 1 27  ? 26.330  -27.026 14.886  1.000 29.177 0 31   GLU A OE1 1 ? 
ATOM   141  O OE2 . GLU A 1 27  ? 26.046  -27.556 12.769  1.000 31.901 0 31   GLU A OE2 1 ? 
ATOM   142  N N   . ILE A 1 28  ? 30.133  -25.246 9.268   1.000 25.566 0 32   ILE A N   1 ? 
ATOM   143  C CA  . ILE A 1 28  ? 30.840  -25.551 8.027   1.000 27.398 0 32   ILE A CA  1 ? 
ATOM   144  C C   . ILE A 1 28  ? 32.350  -25.462 8.238   1.000 26.316 0 32   ILE A C   1 ? 
ATOM   145  O O   . ILE A 1 28  ? 33.113  -26.310 7.755   1.000 26.608 0 32   ILE A O   1 ? 
ATOM   146  C CB  . ILE A 1 28  ? 30.360  -24.615 6.899   1.000 28.722 0 32   ILE A CB  1 ? 
ATOM   147  C CG1 . ILE A 1 28  ? 28.936  -24.992 6.471   1.000 25.092 0 32   ILE A CG1 1 ? 
ATOM   148  C CG2 . ILE A 1 28  ? 31.315  -24.656 5.709   1.000 29.290 0 32   ILE A CG2 1 ? 
ATOM   149  C CD1 . ILE A 1 28  ? 28.310  -23.960 5.533   1.000 25.772 0 32   ILE A CD1 1 ? 
ATOM   150  N N   . ALA A 1 29  ? 32.805  -24.454 8.988   1.000 26.901 0 33   ALA A N   1 ? 
ATOM   151  C CA  . ALA A 1 29  ? 34.236  -24.320 9.248   1.000 28.138 0 33   ALA A CA  1 ? 
ATOM   152  C C   . ALA A 1 29  ? 34.786  -25.546 9.971   1.000 24.324 0 33   ALA A C   1 ? 
ATOM   153  O O   . ALA A 1 29  ? 35.889  -26.014 9.661   1.000 26.037 0 33   ALA A O   1 ? 
ATOM   154  C CB  . ALA A 1 29  ? 34.512  -23.048 10.055  1.000 27.114 0 33   ALA A CB  1 ? 
ATOM   155  N N   . ILE A 1 30  ? 34.030  -26.078 10.939  1.000 22.813 0 34   ILE A N   1 ? 
ATOM   156  C CA  . ILE A 1 30  ? 34.440  -27.303 11.623  1.000 23.234 0 34   ILE A CA  1 ? 
ATOM   157  C C   . ILE A 1 30  ? 34.441  -28.477 10.658  1.000 23.587 0 34   ILE A C   1 ? 
ATOM   158  O O   . ILE A 1 30  ? 35.385  -29.275 10.631  1.000 23.484 0 34   ILE A O   1 ? 
ATOM   159  C CB  . ILE A 1 30  ? 33.518  -27.585 12.823  1.000 24.106 0 34   ILE A CB  1 ? 
ATOM   160  C CG1 . ILE A 1 30  ? 33.644  -26.487 13.870  1.000 26.195 0 34   ILE A CG1 1 ? 
ATOM   161  C CG2 . ILE A 1 30  ? 33.844  -28.946 13.449  1.000 23.782 0 34   ILE A CG2 1 ? 
ATOM   162  C CD1 . ILE A 1 30  ? 32.526  -26.518 14.899  1.000 28.030 0 34   ILE A CD1 1 ? 
ATOM   163  N N   . ALA A 1 31  ? 33.387  -28.592 9.844   1.000 22.108 0 35   ALA A N   1 ? 
ATOM   164  C CA  . ALA A 1 31  ? 33.264  -29.734 8.943   1.000 21.847 0 35   ALA A CA  1 ? 
ATOM   165  C C   . ALA A 1 31  ? 34.406  -29.773 7.934   1.000 24.324 0 35   ALA A C   1 ? 
ATOM   166  O O   . ALA A 1 31  ? 34.906  -30.852 7.601   1.000 22.492 0 35   ALA A O   1 ? 
ATOM   167  C CB  . ALA A 1 31  ? 31.906  -29.692 8.240   1.000 24.213 0 35   ALA A CB  1 ? 
ATOM   168  N N   . GLU A 1 32  ? 34.856  -28.607 7.461   1.000 24.521 0 36   GLU A N   1 ? 
ATOM   169  C CA  . GLU A 1 32  ? 35.984  -28.582 6.534   1.000 24.266 0 36   GLU A CA  1 ? 
ATOM   170  C C   . GLU A 1 32  ? 37.186  -29.324 7.107   1.000 26.298 0 36   GLU A C   1 ? 
ATOM   171  O O   . GLU A 1 32  ? 37.881  -30.048 6.382   1.000 24.821 0 36   GLU A O   1 ? 
ATOM   172  C CB  . GLU A 1 32  ? 36.357  -27.136 6.186   1.000 27.709 0 36   GLU A CB  1 ? 
ATOM   173  C CG  . GLU A 1 32  ? 35.366  -26.476 5.235   1.000 26.435 0 36   GLU A CG  1 ? 
ATOM   174  C CD  . GLU A 1 32  ? 35.650  -24.995 5.001   1.000 34.383 0 36   GLU A CD  1 ? 
ATOM   175  O OE1 . GLU A 1 32  ? 34.827  -24.350 4.315   1.000 34.778 0 36   GLU A OE1 1 ? 
ATOM   176  O OE2 . GLU A 1 32  ? 36.686  -24.478 5.489   1.000 33.507 0 36   GLU A OE2 1 ? 
ATOM   177  N N   . THR A 1 33  ? 37.426  -29.189 8.416   1.000 25.364 0 37   THR A N   1 ? 
ATOM   178  C CA  . THR A 1 33  ? 38.579  -29.860 9.008   1.000 25.035 0 37   THR A CA  1 ? 
ATOM   179  C C   . THR A 1 33  ? 38.393  -31.363 9.119   1.000 26.858 0 37   THR A C   1 ? 
ATOM   180  O O   . THR A 1 33  ? 39.376  -32.064 9.383   1.000 27.027 0 37   THR A O   1 ? 
ATOM   181  C CB  . THR A 1 33  ? 38.902  -29.289 10.393  1.000 25.519 0 37   THR A CB  1 ? 
ATOM   182  O OG1 . THR A 1 33  ? 37.942  -29.755 11.345  1.000 25.637 0 37   THR A OG1 1 ? 
ATOM   183  C CG2 . THR A 1 33  ? 38.895  -27.761 10.355  1.000 28.693 0 37   THR A CG2 1 ? 
ATOM   184  N N   . GLU A 1 34  ? 37.168  -31.862 8.931   1.000 21.958 0 38   GLU A N   1 ? 
ATOM   185  C CA  . GLU A 1 34  ? 36.860  -33.286 8.921   1.000 22.390 0 38   GLU A CA  1 ? 
ATOM   186  C C   . GLU A 1 34  ? 36.700  -33.844 7.517   1.000 21.071 0 38   GLU A C   1 ? 
ATOM   187  O O   . GLU A 1 34  ? 36.406  -35.032 7.370   1.000 22.400 0 38   GLU A O   1 ? 
ATOM   188  C CB  . GLU A 1 34  ? 35.568  -33.552 9.706   1.000 26.358 0 38   GLU A CB  1 ? 
ATOM   189  C CG  . GLU A 1 34  ? 35.731  -33.410 11.190  1.000 27.503 0 38   GLU A CG  1 ? 
ATOM   190  C CD  . GLU A 1 34  ? 36.468  -34.584 11.773  1.000 31.025 0 38   GLU A CD  1 ? 
ATOM   191  O OE1 . GLU A 1 34  ? 37.639  -34.401 12.174  1.000 29.796 0 38   GLU A OE1 1 ? 
ATOM   192  O OE2 . GLU A 1 34  ? 35.876  -35.684 11.803  1.000 30.322 0 38   GLU A OE2 1 ? 
ATOM   193  N N   . MET A 1 35  ? 36.861  -33.023 6.482   1.000 21.229 0 39   MET A N   1 ? 
ATOM   194  C CA  . MET A 1 35  ? 36.541  -33.424 5.113   1.000 21.897 0 39   MET A CA  1 ? 
ATOM   195  C C   . MET A 1 35  ? 37.751  -33.187 4.217   1.000 21.837 0 39   MET A C   1 ? 
ATOM   196  O O   . MET A 1 35  ? 37.722  -32.346 3.307   1.000 23.205 0 39   MET A O   1 ? 
ATOM   197  C CB  . MET A 1 35  ? 35.296  -32.684 4.622   1.000 20.223 0 39   MET A CB  1 ? 
ATOM   198  C CG  . MET A 1 35  ? 34.081  -32.991 5.499   1.000 20.660 0 39   MET A CG  1 ? 
ATOM   199  S SD  . MET A 1 35  ? 32.575  -32.158 4.962   1.000 22.987 0 39   MET A SD  1 ? 
ATOM   200  C CE  . MET A 1 35  ? 31.920  -33.404 3.841   1.000 22.274 0 39   MET A CE  1 ? 
ATOM   201  N N   . PRO A 1 36  ? 38.837  -33.933 4.447   1.000 23.342 0 40   PRO A N   1 ? 
ATOM   202  C CA  . PRO A 1 36  ? 40.083  -33.654 3.718   1.000 22.582 0 40   PRO A CA  1 ? 
ATOM   203  C C   . PRO A 1 36  ? 40.002  -33.947 2.232   1.000 24.421 0 40   PRO A C   1 ? 
ATOM   204  O O   . PRO A 1 36  ? 40.768  -33.357 1.463   1.000 25.006 0 40   PRO A O   1 ? 
ATOM   205  C CB  . PRO A 1 36  ? 41.102  -34.569 4.412   1.000 21.281 0 40   PRO A CB  1 ? 
ATOM   206  C CG  . PRO A 1 36  ? 40.261  -35.697 4.943   1.000 21.842 0 40   PRO A CG  1 ? 
ATOM   207  C CD  . PRO A 1 36  ? 39.000  -35.039 5.407   1.000 23.813 0 40   PRO A CD  1 ? 
ATOM   208  N N   . GLY A 1 37  ? 39.122  -34.853 1.801   1.000 22.324 0 41   GLY A N   1 ? 
ATOM   209  C CA  . GLY A 1 37  ? 39.003  -35.109 0.375   1.000 23.392 0 41   GLY A CA  1 ? 
ATOM   210  C C   . GLY A 1 37  ? 38.501  -33.893 -0.379  1.000 22.724 0 41   GLY A C   1 ? 
ATOM   211  O O   . GLY A 1 37  ? 39.065  -33.497 -1.402  1.000 23.574 0 41   GLY A O   1 ? 
ATOM   212  N N   . LEU A 1 38  ? 37.439  -33.271 0.129   1.000 21.316 0 42   LEU A N   1 ? 
ATOM   213  C CA  . LEU A 1 38  ? 36.913  -32.079 -0.518  1.000 20.929 0 42   LEU A CA  1 ? 
ATOM   214  C C   . LEU A 1 38  ? 37.920  -30.939 -0.457  1.000 25.064 0 42   LEU A C   1 ? 
ATOM   215  O O   . LEU A 1 38  ? 38.095  -30.211 -1.436  1.000 24.829 0 42   LEU A O   1 ? 
ATOM   216  C CB  . LEU A 1 38  ? 35.592  -31.670 0.133   1.000 20.939 0 42   LEU A CB  1 ? 
ATOM   217  C CG  . LEU A 1 38  ? 34.427  -32.629 -0.122  1.000 22.584 0 42   LEU A CG  1 ? 
ATOM   218  C CD1 . LEU A 1 38  ? 33.159  -32.084 0.526   1.000 22.874 0 42   LEU A CD1 1 ? 
ATOM   219  C CD2 . LEU A 1 38  ? 34.227  -32.854 -1.628  1.000 23.795 0 42   LEU A CD2 1 ? 
ATOM   220  N N   . MET A 1 39  ? 38.598  -30.771 0.679   1.000 22.147 0 43   MET A N   1 ? 
ATOM   221  C CA  . MET A 1 39  ? 39.557  -29.676 0.770   1.000 24.334 0 43   MET A CA  1 ? 
ATOM   222  C C   . MET A 1 39  ? 40.757  -29.923 -0.135  1.000 26.108 0 43   MET A C   1 ? 
ATOM   223  O O   . MET A 1 39  ? 41.326  -28.969 -0.686  1.000 25.506 0 43   MET A O   1 ? 
ATOM   224  C CB  . MET A 1 39  ? 39.989  -29.480 2.222   1.000 24.537 0 43   MET A CB  1 ? 
ATOM   225  C CG  . MET A 1 39  ? 38.843  -29.133 3.178   1.000 26.856 0 43   MET A CG  1 ? 
ATOM   226  S SD  . MET A 1 39  ? 37.840  -27.720 2.661   1.000 30.085 0 43   MET A SD  1 ? 
ATOM   227  C CE  . MET A 1 39  ? 39.016  -26.401 2.932   1.000 34.225 0 43   MET A CE  1 ? 
ATOM   228  N N   . ALA A 1 40  ? 41.142  -31.189 -0.314  1.000 25.140 0 44   ALA A N   1 ? 
ATOM   229  C CA  . ALA A 1 40  ? 42.236  -31.508 -1.225  1.000 26.356 0 44   ALA A CA  1 ? 
ATOM   230  C C   . ALA A 1 40  ? 41.858  -31.207 -2.666  1.000 28.219 0 44   ALA A C   1 ? 
ATOM   231  O O   . ALA A 1 40  ? 42.702  -30.761 -3.449  1.000 27.461 0 44   ALA A O   1 ? 
ATOM   232  C CB  . ALA A 1 40  ? 42.647  -32.974 -1.081  1.000 25.021 0 44   ALA A CB  1 ? 
ATOM   233  N N   . LEU A 1 41  ? 40.598  -31.459 -3.042  1.000 25.003 0 45   LEU A N   1 ? 
ATOM   234  C CA  . LEU A 1 41  ? 40.173  -31.126 -4.398  1.000 22.116 0 45   LEU A CA  1 ? 
ATOM   235  C C   . LEU A 1 41  ? 40.179  -29.616 -4.612  1.000 26.587 0 45   LEU A C   1 ? 
ATOM   236  O O   . LEU A 1 41  ? 40.535  -29.138 -5.697  1.000 26.556 0 45   LEU A O   1 ? 
ATOM   237  C CB  . LEU A 1 41  ? 38.788  -31.710 -4.684  1.000 24.808 0 45   LEU A CB  1 ? 
ATOM   238  C CG  . LEU A 1 41  ? 38.692  -33.237 -4.767  1.000 25.271 0 45   LEU A CG  1 ? 
ATOM   239  C CD1 . LEU A 1 41  ? 37.279  -33.639 -5.175  1.000 25.629 0 45   LEU A CD1 1 ? 
ATOM   240  C CD2 . LEU A 1 41  ? 39.731  -33.826 -5.716  1.000 28.245 0 45   LEU A CD2 1 ? 
ATOM   241  N N   . ARG A 1 42  ? 39.791  -28.845 -3.595  1.000 25.150 0 46   ARG A N   1 ? 
ATOM   242  C CA  . ARG A 1 42  ? 39.926  -27.394 -3.703  1.000 27.211 0 46   ARG A CA  1 ? 
ATOM   243  C C   . ARG A 1 42  ? 41.383  -27.001 -3.919  1.000 29.951 0 46   ARG A C   1 ? 
ATOM   244  O O   . ARG A 1 42  ? 41.694  -26.176 -4.783  1.000 29.240 0 46   ARG A O   1 ? 
ATOM   245  C CB  . ARG A 1 42  ? 39.372  -26.706 -2.454  1.000 27.209 0 46   ARG A CB  1 ? 
ATOM   246  C CG  . ARG A 1 42  ? 37.878  -26.899 -2.234  1.000 25.895 0 46   ARG A CG  1 ? 
ATOM   247  C CD  . ARG A 1 42  ? 37.409  -26.095 -1.038  1.000 27.985 0 46   ARG A CD  1 ? 
ATOM   248  N NE  . ARG A 1 42  ? 36.066  -26.476 -0.603  1.000 25.406 0 46   ARG A NE  1 ? 
ATOM   249  C CZ  . ARG A 1 42  ? 35.390  -25.823 0.337   1.000 26.748 0 46   ARG A CZ  1 ? 
ATOM   250  N NH1 . ARG A 1 42  ? 35.938  -24.764 0.929   1.000 30.138 0 46   ARG A NH1 1 ? 
ATOM   251  N NH2 . ARG A 1 42  ? 34.173  -26.219 0.685   1.000 26.556 0 46   ARG A NH2 1 ? 
ATOM   252  N N   . GLU A 1 43  ? 42.292  -27.590 -3.138  1.000 26.843 0 47   GLU A N   1 ? 
ATOM   253  C CA  . GLU A 1 43  ? 43.707  -27.252 -3.275  1.000 27.898 0 47   GLU A CA  1 ? 
ATOM   254  C C   . GLU A 1 43  ? 44.228  -27.623 -4.659  1.000 29.511 0 47   GLU A C   1 ? 
ATOM   255  O O   . GLU A 1 43  ? 44.996  -26.866 -5.271  1.000 28.925 0 47   GLU A O   1 ? 
ATOM   256  C CB  . GLU A 1 43  ? 44.509  -27.953 -2.175  1.000 31.154 0 47   GLU A CB  1 ? 
ATOM   257  C CG  . GLU A 1 43  ? 46.023  -27.840 -2.314  1.000 46.256 0 47   GLU A CG  1 ? 
ATOM   258  C CD  . GLU A 1 43  ? 46.524  -26.418 -2.155  1.000 61.226 0 47   GLU A CD  1 ? 
ATOM   259  O OE1 . GLU A 1 43  ? 45.867  -25.630 -1.440  1.000 64.637 0 47   GLU A OE1 1 ? 
ATOM   260  O OE2 . GLU A 1 43  ? 47.576  -26.087 -2.744  1.000 65.045 0 47   GLU A OE2 1 ? 
ATOM   261  N N   . GLU A 1 44  ? 43.795  -28.771 -5.187  1.000 29.111 0 48   GLU A N   1 ? 
ATOM   262  C CA  . GLU A 1 44  ? 44.290  -29.227 -6.484  1.000 26.569 0 48   GLU A CA  1 ? 
ATOM   263  C C   . GLU A 1 44  ? 43.675  -28.451 -7.649  1.000 27.251 0 48   GLU A C   1 ? 
ATOM   264  O O   . GLU A 1 44  ? 44.361  -28.171 -8.640  1.000 29.833 0 48   GLU A O   1 ? 
ATOM   265  C CB  . GLU A 1 44  ? 44.019  -30.730 -6.648  1.000 25.887 0 48   GLU A CB  1 ? 
ATOM   266  C CG  . GLU A 1 44  ? 44.394  -31.254 -8.024  1.000 28.946 0 48   GLU A CG  1 ? 
ATOM   267  C CD  . GLU A 1 44  ? 44.324  -32.760 -8.140  1.000 35.449 0 48   GLU A CD  1 ? 
ATOM   268  O OE1 . GLU A 1 44  ? 43.744  -33.408 -7.237  1.000 33.093 0 48   GLU A OE1 1 ? 
ATOM   269  O OE2 . GLU A 1 44  ? 44.854  -33.292 -9.143  1.000 37.323 0 48   GLU A OE2 1 ? 
ATOM   270  N N   . PHE A 1 45  ? 42.395  -28.079 -7.555  1.000 29.182 0 49   PHE A N   1 ? 
ATOM   271  C CA  . PHE A 1 45  ? 41.651  -27.656 -8.734  1.000 27.153 0 49   PHE A CA  1 ? 
ATOM   272  C C   . PHE A 1 45  ? 41.076  -26.244 -8.693  1.000 30.059 0 49   PHE A C   1 ? 
ATOM   273  O O   . PHE A 1 45  ? 40.572  -25.787 -9.723  1.000 32.641 0 49   PHE A O   1 ? 
ATOM   274  C CB  . PHE A 1 45  ? 40.488  -28.626 -8.998  1.000 28.140 0 49   PHE A CB  1 ? 
ATOM   275  C CG  . PHE A 1 45  ? 40.915  -29.967 -9.512  1.000 30.390 0 49   PHE A CG  1 ? 
ATOM   276  C CD1 . PHE A 1 45  ? 41.543  -30.084 -10.743 1.000 30.696 0 49   PHE A CD1 1 ? 
ATOM   277  C CD2 . PHE A 1 45  ? 40.668  -31.116 -8.775  1.000 30.962 0 49   PHE A CD2 1 ? 
ATOM   278  C CE1 . PHE A 1 45  ? 41.925  -31.323 -11.228 1.000 33.146 0 49   PHE A CE1 1 ? 
ATOM   279  C CE2 . PHE A 1 45  ? 41.053  -32.359 -9.254  1.000 32.462 0 49   PHE A CE2 1 ? 
ATOM   280  C CZ  . PHE A 1 45  ? 41.686  -32.459 -10.486 1.000 32.425 0 49   PHE A CZ  1 ? 
ATOM   281  N N   . SER A 1 46  ? 41.112  -25.539 -7.559  1.000 34.686 0 50   SER A N   1 ? 
ATOM   282  C CA  . SER A 1 46  ? 40.384  -24.268 -7.493  1.000 31.920 0 50   SER A CA  1 ? 
ATOM   283  C C   . SER A 1 46  ? 40.991  -23.206 -8.401  1.000 38.255 0 50   SER A C   1 ? 
ATOM   284  O O   . SER A 1 46  ? 40.281  -22.288 -8.832  1.000 40.450 0 50   SER A O   1 ? 
ATOM   285  C CB  . SER A 1 46  ? 40.320  -23.749 -6.057  1.000 38.615 0 50   SER A CB  1 ? 
ATOM   286  O OG  . SER A 1 46  ? 41.584  -23.284 -5.624  1.000 40.113 0 50   SER A OG  1 ? 
ATOM   287  N N   . ALA A 1 47  ? 42.289  -23.298 -8.696  1.000 36.770 0 51   ALA A N   1 ? 
ATOM   288  C CA  . ALA A 1 47  ? 42.905  -22.320 -9.589  1.000 37.478 0 51   ALA A CA  1 ? 
ATOM   289  C C   . ALA A 1 47  ? 42.620  -22.632 -11.055 1.000 38.357 0 51   ALA A C   1 ? 
ATOM   290  O O   . ALA A 1 47  ? 42.362  -21.717 -11.848 1.000 38.731 0 51   ALA A O   1 ? 
ATOM   291  C CB  . ALA A 1 47  ? 44.413  -22.253 -9.340  1.000 40.007 0 51   ALA A CB  1 ? 
ATOM   292  N N   . LYS A 1 48  ? 42.673  -23.911 -11.439 1.000 35.644 0 52   LYS A N   1 ? 
ATOM   293  C CA  . LYS A 1 48  ? 42.412  -24.288 -12.824 1.000 39.905 0 52   LYS A CA  1 ? 
ATOM   294  C C   . LYS A 1 48  ? 40.930  -24.243 -13.166 1.000 37.994 0 52   LYS A C   1 ? 
ATOM   295  O O   . LYS A 1 48  ? 40.583  -24.158 -14.348 1.000 37.636 0 52   LYS A O   1 ? 
ATOM   296  C CB  . LYS A 1 48  ? 42.957  -25.691 -13.101 1.000 47.264 0 52   LYS A CB  1 ? 
ATOM   297  C CG  . LYS A 1 48  ? 44.409  -25.892 -12.700 1.000 57.473 0 52   LYS A CG  1 ? 
ATOM   298  C CD  . LYS A 1 48  ? 45.106  -26.871 -13.635 1.000 65.505 0 52   LYS A CD  1 ? 
ATOM   299  C CE  . LYS A 1 48  ? 46.012  -27.831 -12.873 1.000 68.032 0 52   LYS A CE  1 ? 
ATOM   300  N NZ  . LYS A 1 48  ? 47.077  -27.125 -12.103 1.000 69.572 0 52   LYS A NZ  1 ? 
ATOM   301  N N   . LYS A 1 49  ? 40.059  -24.311 -12.165 1.000 36.302 0 53   LYS A N   1 ? 
ATOM   302  C CA  . LYS A 1 49  ? 38.608  -24.266 -12.320 1.000 34.862 0 53   LYS A CA  1 ? 
ATOM   303  C C   . LYS A 1 49  ? 38.109  -25.225 -13.401 1.000 34.799 0 53   LYS A C   1 ? 
ATOM   304  O O   . LYS A 1 49  ? 37.563  -24.785 -14.423 1.000 36.010 0 53   LYS A O   1 ? 
ATOM   305  C CB  . LYS A 1 49  ? 38.165  -22.832 -12.611 1.000 40.397 0 53   LYS A CB  1 ? 
ATOM   306  C CG  . LYS A 1 49  ? 38.521  -21.865 -11.485 1.000 46.987 0 53   LYS A CG  1 ? 
ATOM   307  C CD  . LYS A 1 49  ? 37.564  -20.692 -11.402 1.000 54.367 0 53   LYS A CD  1 ? 
ATOM   308  C CE  . LYS A 1 49  ? 37.111  -20.445 -9.969  1.000 56.770 0 53   LYS A CE  1 ? 
ATOM   309  N NZ  . LYS A 1 49  ? 38.234  -20.478 -8.992  1.000 56.196 0 53   LYS A NZ  1 ? 
ATOM   310  N N   . PRO A 1 50  ? 38.240  -26.540 -13.199 1.000 33.822 0 54   PRO A N   1 ? 
ATOM   311  C CA  . PRO A 1 50  ? 37.787  -27.490 -14.229 1.000 33.030 0 54   PRO A CA  1 ? 
ATOM   312  C C   . PRO A 1 50  ? 36.279  -27.506 -14.442 1.000 34.575 0 54   PRO A C   1 ? 
ATOM   313  O O   . PRO A 1 50  ? 35.823  -28.064 -15.450 1.000 34.383 0 54   PRO A O   1 ? 
ATOM   314  C CB  . PRO A 1 50  ? 38.283  -28.842 -13.699 1.000 35.373 0 54   PRO A CB  1 ? 
ATOM   315  C CG  . PRO A 1 50  ? 38.352  -28.652 -12.209 1.000 34.530 0 54   PRO A CG  1 ? 
ATOM   316  C CD  . PRO A 1 50  ? 38.823  -27.226 -12.033 1.000 33.309 0 54   PRO A CD  1 ? 
ATOM   317  N N   . LEU A 1 51  ? 35.489  -26.942 -13.528 1.000 29.993 0 55   LEU A N   1 ? 
ATOM   318  C CA  . LEU A 1 51  ? 34.040  -26.892 -13.685 1.000 27.653 0 55   LEU A CA  1 ? 
ATOM   319  C C   . LEU A 1 51  ? 33.543  -25.518 -14.125 1.000 28.938 0 55   LEU A C   1 ? 
ATOM   320  O O   . LEU A 1 51  ? 32.339  -25.249 -14.051 1.000 31.904 0 55   LEU A O   1 ? 
ATOM   321  C CB  . LEU A 1 51  ? 33.349  -27.314 -12.383 1.000 30.014 0 55   LEU A CB  1 ? 
ATOM   322  C CG  . LEU A 1 51  ? 33.576  -28.767 -11.954 1.000 27.232 0 55   LEU A CG  1 ? 
ATOM   323  C CD1 . LEU A 1 51  ? 32.925  -29.038 -10.599 1.000 26.343 0 55   LEU A CD1 1 ? 
ATOM   324  C CD2 . LEU A 1 51  ? 33.026  -29.722 -13.009 1.000 28.546 0 55   LEU A CD2 1 ? 
ATOM   325  N N   . GLN A 1 52  ? 34.441  -24.634 -14.565 1.000 31.212 0 56   GLN A N   1 ? 
ATOM   326  C CA  . GLN A 1 52  ? 34.013  -23.380 -15.176 1.000 31.104 0 56   GLN A CA  1 ? 
ATOM   327  C C   . GLN A 1 52  ? 33.178  -23.671 -16.421 1.000 34.546 0 56   GLN A C   1 ? 
ATOM   328  O O   . GLN A 1 52  ? 33.647  -24.321 -17.361 1.000 33.483 0 56   GLN A O   1 ? 
ATOM   329  C CB  . GLN A 1 52  ? 35.231  -22.526 -15.532 1.000 35.473 0 56   GLN A CB  1 ? 
ATOM   330  C CG  . GLN A 1 52  ? 34.884  -21.131 -16.019 1.000 44.018 0 56   GLN A CG  1 ? 
ATOM   331  C CD  . GLN A 1 52  ? 34.143  -20.320 -14.975 1.000 54.954 0 56   GLN A CD  1 ? 
ATOM   332  O OE1 . GLN A 1 52  ? 33.007  -19.897 -15.192 1.000 62.979 0 56   GLN A OE1 1 ? 
ATOM   333  N NE2 . GLN A 1 52  ? 34.782  -20.104 -13.830 1.000 54.041 0 56   GLN A NE2 1 ? 
ATOM   334  N N   . GLY A 1 53  ? 31.932  -23.207 -16.418 1.000 33.001 0 57   GLY A N   1 ? 
ATOM   335  C CA  . GLY A 1 53  ? 30.987  -23.549 -17.457 1.000 33.165 0 57   GLY A CA  1 ? 
ATOM   336  C C   . GLY A 1 53  ? 30.037  -24.666 -17.086 1.000 33.836 0 57   GLY A C   1 ? 
ATOM   337  O O   . GLY A 1 53  ? 29.102  -24.945 -17.851 1.000 33.259 0 57   GLY A O   1 ? 
ATOM   338  N N   . ALA A 1 54  ? 30.252  -25.315 -15.945 1.000 30.625 0 58   ALA A N   1 ? 
ATOM   339  C CA  . ALA A 1 54  ? 29.324  -26.327 -15.467 1.000 28.796 0 58   ALA A CA  1 ? 
ATOM   340  C C   . ALA A 1 54  ? 28.145  -25.652 -14.785 1.000 32.206 0 58   ALA A C   1 ? 
ATOM   341  O O   . ALA A 1 54  ? 28.314  -24.691 -14.027 1.000 35.109 0 58   ALA A O   1 ? 
ATOM   342  C CB  . ALA A 1 54  ? 30.018  -27.287 -14.496 1.000 28.443 0 58   ALA A CB  1 ? 
ATOM   343  N N   . ARG A 1 55  ? 26.946  -26.146 -15.079 1.000 29.296 0 59   ARG A N   1 ? 
ATOM   344  C CA  . ARG A 1 55  ? 25.705  -25.631 -14.502 1.000 28.827 0 59   ARG A CA  1 ? 
ATOM   345  C C   . ARG A 1 55  ? 24.986  -26.834 -13.898 1.000 27.732 0 59   ARG A C   1 ? 
ATOM   346  O O   . ARG A 1 55  ? 24.353  -27.611 -14.619 1.000 27.985 0 59   ARG A O   1 ? 
ATOM   347  C CB  . ARG A 1 55  ? 24.856  -24.927 -15.556 1.000 31.491 0 59   ARG A CB  1 ? 
ATOM   348  C CG  . ARG A 1 55  ? 25.506  -23.652 -16.106 1.000 32.109 0 59   ARG A CG  1 ? 
ATOM   349  C CD  . ARG A 1 55  ? 24.564  -22.869 -17.023 1.000 32.775 0 59   ARG A CD  1 ? 
ATOM   350  N NE  . ARG A 1 55  ? 24.097  -23.691 -18.138 1.000 39.068 0 59   ARG A NE  1 ? 
ATOM   351  C CZ  . ARG A 1 55  ? 24.789  -23.914 -19.254 1.000 39.692 0 59   ARG A CZ  1 ? 
ATOM   352  N NH1 . ARG A 1 55  ? 25.988  -23.367 -19.423 1.000 36.378 0 59   ARG A NH1 1 ? 
ATOM   353  N NH2 . ARG A 1 55  ? 24.275  -24.682 -20.209 1.000 39.349 0 59   ARG A NH2 1 ? 
ATOM   354  N N   . ILE A 1 56  ? 25.102  -27.003 -12.587 1.000 25.379 0 60   ILE A N   1 ? 
ATOM   355  C CA  . ILE A 1 56  ? 24.706  -28.243 -11.928 1.000 25.224 0 60   ILE A CA  1 ? 
ATOM   356  C C   . ILE A 1 56  ? 23.389  -28.031 -11.203 1.000 29.096 0 60   ILE A C   1 ? 
ATOM   357  O O   . ILE A 1 56  ? 23.291  -27.182 -10.309 1.000 28.338 0 60   ILE A O   1 ? 
ATOM   358  C CB  . ILE A 1 56  ? 25.780  -28.733 -10.949 1.000 23.958 0 60   ILE A CB  1 ? 
ATOM   359  C CG1 . ILE A 1 56  ? 27.122  -28.914 -11.663 1.000 27.930 0 60   ILE A CG1 1 ? 
ATOM   360  C CG2 . ILE A 1 56  ? 25.316  -30.044 -10.288 1.000 26.211 0 60   ILE A CG2 1 ? 
ATOM   361  C CD1 . ILE A 1 56  ? 28.294  -29.109 -10.700 1.000 25.766 0 60   ILE A CD1 1 ? 
ATOM   362  N N   . ALA A 1 57  ? 22.383  -28.814 -11.584 1.000 28.111 0 61   ALA A N   1 ? 
ATOM   363  C CA  . ALA A 1 57  ? 21.172  -28.981 -10.795 1.000 27.269 0 61   ALA A CA  1 ? 
ATOM   364  C C   . ALA A 1 57  ? 21.409  -30.101 -9.786  1.000 27.022 0 61   ALA A C   1 ? 
ATOM   365  O O   . ALA A 1 57  ? 21.725  -31.228 -10.178 1.000 25.624 0 61   ALA A O   1 ? 
ATOM   366  C CB  . ALA A 1 57  ? 19.985  -29.312 -11.703 1.000 31.251 0 61   ALA A CB  1 ? 
ATOM   367  N N   . GLY A 1 58  ? 21.277  -29.799 -8.499  1.000 24.229 0 62   GLY A N   1 ? 
ATOM   368  C CA  . GLY A 1 58  ? 21.562  -30.767 -7.445  1.000 23.271 0 62   GLY A CA  1 ? 
ATOM   369  C C   . GLY A 1 58  ? 20.344  -31.054 -6.591  1.000 25.972 0 62   GLY A C   1 ? 
ATOM   370  O O   . GLY A 1 58  ? 19.605  -30.141 -6.228  1.000 26.872 0 62   GLY A O   1 ? 
ATOM   371  N N   . CYS A 1 59  ? 20.149  -32.335 -6.264  1.000 24.306 0 63   CYS A N   1 ? 
ATOM   372  C CA  . CYS A 1 59  ? 19.051  -32.792 -5.409  1.000 27.024 0 63   CYS A CA  1 ? 
ATOM   373  C C   . CYS A 1 59  ? 19.658  -33.777 -4.414  1.000 26.303 0 63   CYS A C   1 ? 
ATOM   374  O O   . CYS A 1 59  ? 19.811  -34.969 -4.702  1.000 22.663 0 63   CYS A O   1 ? 
ATOM   375  C CB  . CYS A 1 59  ? 17.935  -33.407 -6.239  1.000 26.066 0 63   CYS A CB  1 ? 
ATOM   376  S SG  . CYS A 1 59  ? 16.491  -33.929 -5.287  1.000 26.964 0 63   CYS A SG  1 ? 
ATOM   377  N N   . LEU A 1 60  ? 20.014  -33.268 -3.238  1.000 21.884 0 64   LEU A N   1 ? 
ATOM   378  C CA  . LEU A 1 60  ? 20.748  -34.055 -2.253  1.000 22.158 0 64   LEU A CA  1 ? 
ATOM   379  C C   . LEU A 1 60  ? 20.609  -33.363 -0.905  1.000 24.008 0 64   LEU A C   1 ? 
ATOM   380  O O   . LEU A 1 60  ? 20.786  -32.144 -0.830  1.000 26.161 0 64   LEU A O   1 ? 
ATOM   381  C CB  . LEU A 1 60  ? 22.229  -34.190 -2.654  1.000 23.008 0 64   LEU A CB  1 ? 
ATOM   382  C CG  . LEU A 1 60  ? 23.026  -35.312 -1.980  1.000 25.321 0 64   LEU A CG  1 ? 
ATOM   383  C CD1 . LEU A 1 60  ? 24.163  -35.819 -2.885  1.000 24.084 0 64   LEU A CD1 1 ? 
ATOM   384  C CD2 . LEU A 1 60  ? 23.575  -34.853 -0.642  1.000 25.695 0 64   LEU A CD2 1 ? 
ATOM   385  N N   . HIS A 1 61  ? 20.301  -34.145 0.143   1.000 22.468 0 65   HIS A N   1 ? 
ATOM   386  C CA  . HIS A 1 61  ? 20.086  -33.671 1.515   1.000 23.974 0 65   HIS A CA  1 ? 
ATOM   387  C C   . HIS A 1 61  ? 20.886  -32.423 1.864   1.000 22.334 0 65   HIS A C   1 ? 
ATOM   388  O O   . HIS A 1 61  ? 22.118  -32.457 1.852   1.000 23.961 0 65   HIS A O   1 ? 
ATOM   389  C CB  . HIS A 1 61  ? 20.452  -34.763 2.523   1.000 21.300 0 65   HIS A CB  1 ? 
ATOM   390  C CG  . HIS A 1 61  ? 19.861  -36.099 2.207   1.000 21.929 0 65   HIS A CG  1 ? 
ATOM   391  N ND1 . HIS A 1 61  ? 18.515  -36.369 2.348   1.000 23.292 0 65   HIS A ND1 1 ? 
ATOM   392  C CD2 . HIS A 1 61  ? 20.430  -37.238 1.749   1.000 22.984 0 65   HIS A CD2 1 ? 
ATOM   393  C CE1 . HIS A 1 61  ? 18.284  -37.624 2.004   1.000 22.066 0 65   HIS A CE1 1 ? 
ATOM   394  N NE2 . HIS A 1 61  ? 19.431  -38.174 1.640   1.000 21.934 0 65   HIS A NE2 1 ? 
ATOM   395  N N   . MET A 1 62  ? 20.199  -31.325 2.189   1.000 22.490 0 66   MET A N   1 ? 
ATOM   396  C CA  . MET A 1 62  ? 20.862  -30.029 2.364   1.000 24.706 0 66   MET A CA  1 ? 
ATOM   397  C C   . MET A 1 62  ? 21.389  -29.910 3.795   1.000 24.329 0 66   MET A C   1 ? 
ATOM   398  O O   . MET A 1 62  ? 20.873  -29.173 4.636   1.000 25.674 0 66   MET A O   1 ? 
ATOM   399  C CB  . MET A 1 62  ? 19.907  -28.893 2.011   1.000 23.226 0 66   MET A CB  1 ? 
ATOM   400  C CG  . MET A 1 62  ? 20.535  -27.492 2.095   1.000 25.561 0 66   MET A CG  1 ? 
ATOM   401  S SD  . MET A 1 62  ? 21.910  -27.261 0.942   1.000 27.485 0 66   MET A SD  1 ? 
ATOM   402  C CE  . MET A 1 62  ? 23.316  -27.299 2.052   1.000 25.106 0 66   MET A CE  1 ? 
ATOM   403  N N   . THR A 1 63  ? 22.463  -30.653 4.053   1.000 23.971 0 67   THR A N   1 ? 
ATOM   404  C CA  . THR A 1 63  ? 23.121  -30.695 5.350   1.000 23.163 0 67   THR A CA  1 ? 
ATOM   405  C C   . THR A 1 63  ? 24.367  -29.815 5.354   1.000 25.195 0 67   THR A C   1 ? 
ATOM   406  O O   . THR A 1 63  ? 24.791  -29.281 4.326   1.000 23.845 0 67   THR A O   1 ? 
ATOM   407  C CB  . THR A 1 63  ? 23.542  -32.120 5.688   1.000 23.900 0 67   THR A CB  1 ? 
ATOM   408  O OG1 . THR A 1 63  ? 24.499  -32.531 4.704   1.000 23.490 0 67   THR A OG1 1 ? 
ATOM   409  C CG2 . THR A 1 63  ? 22.336  -33.079 5.689   1.000 22.832 0 67   THR A CG2 1 ? 
ATOM   410  N N   . ILE A 1 64  ? 24.990  -29.712 6.532   1.000 23.269 0 68   ILE A N   1 ? 
ATOM   411  C CA  . ILE A 1 64  ? 26.272  -29.019 6.648   1.000 23.819 0 68   ILE A CA  1 ? 
ATOM   412  C C   . ILE A 1 64  ? 27.308  -29.672 5.742   1.000 23.940 0 68   ILE A C   1 ? 
ATOM   413  O O   . ILE A 1 64  ? 28.112  -28.992 5.096   1.000 22.263 0 68   ILE A O   1 ? 
ATOM   414  C CB  . ILE A 1 64  ? 26.740  -29.005 8.118   1.000 24.069 0 68   ILE A CB  1 ? 
ATOM   415  C CG1 . ILE A 1 64  ? 25.859  -28.075 8.965   1.000 23.392 0 68   ILE A CG1 1 ? 
ATOM   416  C CG2 . ILE A 1 64  ? 28.200  -28.587 8.221   1.000 26.379 0 68   ILE A CG2 1 ? 
ATOM   417  C CD1 . ILE A 1 64  ? 26.084  -26.591 8.683   1.000 25.935 0 68   ILE A CD1 1 ? 
ATOM   418  N N   . GLN A 1 65  ? 27.301  -31.005 5.678   1.000 22.726 0 69   GLN A N   1 ? 
ATOM   419  C CA  . GLN A 1 65  ? 28.273  -31.700 4.841   1.000 20.023 0 69   GLN A CA  1 ? 
ATOM   420  C C   . GLN A 1 65  ? 28.033  -31.401 3.367   1.000 25.293 0 69   GLN A C   1 ? 
ATOM   421  O O   . GLN A 1 65  ? 28.983  -31.189 2.598   1.000 23.627 0 69   GLN A O   1 ? 
ATOM   422  C CB  . GLN A 1 65  ? 28.205  -33.200 5.116   1.000 22.450 0 69   GLN A CB  1 ? 
ATOM   423  C CG  . GLN A 1 65  ? 28.680  -33.597 6.519   1.000 22.900 0 69   GLN A CG  1 ? 
ATOM   424  C CD  . GLN A 1 65  ? 27.794  -33.066 7.638   1.000 25.585 0 69   GLN A CD  1 ? 
ATOM   425  O OE1 . GLN A 1 65  ? 26.568  -33.030 7.521   1.000 25.248 0 69   GLN A OE1 1 ? 
ATOM   426  N NE2 . GLN A 1 65  ? 28.419  -32.622 8.720   1.000 25.882 0 69   GLN A NE2 1 ? 
ATOM   427  N N   . THR A 1 66  ? 26.768  -31.363 2.956   1.000 22.526 0 70   THR A N   1 ? 
ATOM   428  C CA  . THR A 1 66  ? 26.456  -31.016 1.575   1.000 21.900 0 70   THR A CA  1 ? 
ATOM   429  C C   . THR A 1 66  ? 26.834  -29.575 1.266   1.000 25.243 0 70   THR A C   1 ? 
ATOM   430  O O   . THR A 1 66  ? 27.208  -29.267 0.129   1.000 23.953 0 70   THR A O   1 ? 
ATOM   431  C CB  . THR A 1 66  ? 24.975  -31.276 1.323   1.000 22.666 0 70   THR A CB  1 ? 
ATOM   432  O OG1 . THR A 1 66  ? 24.747  -32.681 1.476   1.000 21.958 0 70   THR A OG1 1 ? 
ATOM   433  C CG2 . THR A 1 66  ? 24.552  -30.857 -0.079  1.000 24.795 0 70   THR A CG2 1 ? 
ATOM   434  N N   . ALA A 1 67  ? 26.771  -28.685 2.262   1.000 25.619 0 71   ALA A N   1 ? 
ATOM   435  C CA  . ALA A 1 67  ? 27.229  -27.317 2.043   1.000 25.506 0 71   ALA A CA  1 ? 
ATOM   436  C C   . ALA A 1 67  ? 28.707  -27.289 1.666   1.000 25.269 0 71   ALA A C   1 ? 
ATOM   437  O O   . ALA A 1 67  ? 29.117  -26.493 0.813   1.000 26.906 0 71   ALA A O   1 ? 
ATOM   438  C CB  . ALA A 1 67  ? 26.972  -26.460 3.284   1.000 23.437 0 71   ALA A CB  1 ? 
ATOM   439  N N   . VAL A 1 68  ? 29.520  -28.164 2.273   1.000 23.295 0 72   VAL A N   1 ? 
ATOM   440  C CA  . VAL A 1 68  ? 30.935  -28.229 1.900   1.000 24.340 0 72   VAL A CA  1 ? 
ATOM   441  C C   . VAL A 1 68  ? 31.086  -28.764 0.479   1.000 24.640 0 72   VAL A C   1 ? 
ATOM   442  O O   . VAL A 1 68  ? 31.943  -28.303 -0.286  1.000 26.743 0 72   VAL A O   1 ? 
ATOM   443  C CB  . VAL A 1 68  ? 31.732  -29.078 2.912   1.000 25.598 0 72   VAL A CB  1 ? 
ATOM   444  C CG1 . VAL A 1 68  ? 33.228  -29.069 2.556   1.000 24.482 0 72   VAL A CG1 1 ? 
ATOM   445  C CG2 . VAL A 1 68  ? 31.529  -28.556 4.327   1.000 24.642 0 72   VAL A CG2 1 ? 
ATOM   446  N N   . LEU A 1 69  ? 30.257  -29.744 0.101   1.000 24.442 0 73   LEU A N   1 ? 
ATOM   447  C CA  . LEU A 1 69  ? 30.235  -30.216 -1.283  1.000 22.924 0 73   LEU A CA  1 ? 
ATOM   448  C C   . LEU A 1 69  ? 29.889  -29.081 -2.245  1.000 24.637 0 73   LEU A C   1 ? 
ATOM   449  O O   . LEU A 1 69  ? 30.575  -28.871 -3.255  1.000 25.285 0 73   LEU A O   1 ? 
ATOM   450  C CB  . LEU A 1 69  ? 29.231  -31.372 -1.427  1.000 22.555 0 73   LEU A CB  1 ? 
ATOM   451  C CG  . LEU A 1 69  ? 28.826  -31.753 -2.864  1.000 22.800 0 73   LEU A CG  1 ? 
ATOM   452  C CD1 . LEU A 1 69  ? 30.030  -32.186 -3.697  1.000 23.905 0 73   LEU A CD1 1 ? 
ATOM   453  C CD2 . LEU A 1 69  ? 27.759  -32.856 -2.877  1.000 23.708 0 73   LEU A CD2 1 ? 
ATOM   454  N N   . ILE A 1 70  ? 28.825  -28.338 -1.944  1.000 24.148 0 74   ILE A N   1 ? 
ATOM   455  C CA  . ILE A 1 70  ? 28.386  -27.264 -2.836  1.000 23.282 0 74   ILE A CA  1 ? 
ATOM   456  C C   . ILE A 1 70  ? 29.489  -26.227 -3.005  1.000 27.682 0 74   ILE A C   1 ? 
ATOM   457  O O   . ILE A 1 70  ? 29.790  -25.787 -4.120  1.000 26.356 0 74   ILE A O   1 ? 
ATOM   458  C CB  . ILE A 1 70  ? 27.090  -26.621 -2.307  1.000 24.213 0 74   ILE A CB  1 ? 
ATOM   459  C CG1 . ILE A 1 70  ? 25.906  -27.582 -2.476  1.000 26.785 0 74   ILE A CG1 1 ? 
ATOM   460  C CG2 . ILE A 1 70  ? 26.837  -25.279 -3.013  1.000 27.780 0 74   ILE A CG2 1 ? 
ATOM   461  C CD1 . ILE A 1 70  ? 24.705  -27.215 -1.605  1.000 28.990 0 74   ILE A CD1 1 ? 
ATOM   462  N N   . GLU A 1 71  ? 30.112  -25.826 -1.898  1.000 28.938 0 75   GLU A N   1 ? 
ATOM   463  C CA  . GLU A 1 71  ? 31.137  -24.798 -1.987  1.000 31.525 0 75   GLU A CA  1 ? 
ATOM   464  C C   . GLU A 1 71  ? 32.404  -25.315 -2.655  1.000 29.438 0 75   GLU A C   1 ? 
ATOM   465  O O   . GLU A 1 71  ? 33.166  -24.517 -3.212  1.000 30.233 0 75   GLU A O   1 ? 
ATOM   466  C CB  . GLU A 1 71  ? 31.415  -24.237 -0.592  1.000 29.998 0 75   GLU A CB  1 ? 
ATOM   467  C CG  . GLU A 1 71  ? 30.197  -23.490 -0.038  1.000 31.780 0 75   GLU A CG  1 ? 
ATOM   468  C CD  . GLU A 1 71  ? 30.486  -22.672 1.203   1.000 40.405 0 75   GLU A CD  1 ? 
ATOM   469  O OE1 . GLU A 1 71  ? 29.968  -21.539 1.293   1.000 48.406 0 75   GLU A OE1 1 ? 
ATOM   470  O OE2 . GLU A 1 71  ? 31.217  -23.150 2.091   1.000 36.596 0 75   GLU A OE2 1 ? 
ATOM   471  N N   . THR A 1 72  ? 32.628  -26.633 -2.640  1.000 25.927 0 76   THR A N   1 ? 
ATOM   472  C CA  . THR A 1 72  ? 33.725  -27.203 -3.415  1.000 26.811 0 76   THR A CA  1 ? 
ATOM   473  C C   . THR A 1 72  ? 33.428  -27.133 -4.909  1.000 29.306 0 76   THR A C   1 ? 
ATOM   474  O O   . THR A 1 72  ? 34.298  -26.756 -5.709  1.000 26.490 0 76   THR A O   1 ? 
ATOM   475  C CB  . THR A 1 72  ? 33.970  -28.649 -2.985  1.000 24.003 0 76   THR A CB  1 ? 
ATOM   476  O OG1 . THR A 1 72  ? 34.311  -28.684 -1.596  1.000 24.858 0 76   THR A OG1 1 ? 
ATOM   477  C CG2 . THR A 1 72  ? 35.111  -29.266 -3.799  1.000 27.703 0 76   THR A CG2 1 ? 
ATOM   478  N N   . LEU A 1 73  ? 32.202  -27.491 -5.305  1.000 24.395 0 77   LEU A N   1 ? 
ATOM   479  C CA  . LEU A 1 73  ? 31.818  -27.377 -6.712  1.000 25.358 0 77   LEU A CA  1 ? 
ATOM   480  C C   . LEU A 1 73  ? 31.976  -25.948 -7.202  1.000 28.814 0 77   LEU A C   1 ? 
ATOM   481  O O   . LEU A 1 73  ? 32.488  -25.713 -8.303  1.000 26.440 0 77   LEU A O   1 ? 
ATOM   482  C CB  . LEU A 1 73  ? 30.371  -27.845 -6.915  1.000 24.587 0 77   LEU A CB  1 ? 
ATOM   483  C CG  . LEU A 1 73  ? 30.102  -29.328 -6.643  1.000 26.314 0 77   LEU A CG  1 ? 
ATOM   484  C CD1 . LEU A 1 73  ? 28.602  -29.613 -6.567  1.000 24.627 0 77   LEU A CD1 1 ? 
ATOM   485  C CD2 . LEU A 1 73  ? 30.769  -30.188 -7.716  1.000 25.761 0 77   LEU A CD2 1 ? 
ATOM   486  N N   . VAL A 1 74  ? 31.534  -24.981 -6.394  1.000 29.164 0 78   VAL A N   1 ? 
ATOM   487  C CA  . VAL A 1 74  ? 31.610  -23.575 -6.771  1.000 28.272 0 78   VAL A CA  1 ? 
ATOM   488  C C   . VAL A 1 74  ? 33.063  -23.115 -6.829  1.000 28.469 0 78   VAL A C   1 ? 
ATOM   489  O O   . VAL A 1 74  ? 33.460  -22.381 -7.743  1.000 30.372 0 78   VAL A O   1 ? 
ATOM   490  C CB  . VAL A 1 74  ? 30.779  -22.728 -5.788  1.000 29.432 0 78   VAL A CB  1 ? 
ATOM   491  C CG1 . VAL A 1 74  ? 31.089  -21.243 -5.954  1.000 31.562 0 78   VAL A CG1 1 ? 
ATOM   492  C CG2 . VAL A 1 74  ? 29.284  -22.984 -5.988  1.000 31.862 0 78   VAL A CG2 1 ? 
ATOM   493  N N   . ALA A 1 75  ? 33.880  -23.546 -5.865  1.000 28.767 0 79   ALA A N   1 ? 
ATOM   494  C CA  . ALA A 1 75  ? 35.293  -23.172 -5.872  1.000 28.488 0 79   ALA A CA  1 ? 
ATOM   495  C C   . ALA A 1 75  ? 35.994  -23.681 -7.121  1.000 31.133 0 79   ALA A C   1 ? 
ATOM   496  O O   . ALA A 1 75  ? 36.981  -23.084 -7.572  1.000 30.196 0 79   ALA A O   1 ? 
ATOM   497  C CB  . ALA A 1 75  ? 35.983  -23.719 -4.621  1.000 30.259 0 79   ALA A CB  1 ? 
ATOM   498  N N   . LEU A 1 76  ? 35.505  -24.778 -7.692  1.000 28.811 0 80   LEU A N   1 ? 
ATOM   499  C CA  . LEU A 1 76  ? 36.066  -25.333 -8.915  1.000 27.151 0 80   LEU A CA  1 ? 
ATOM   500  C C   . LEU A 1 76  ? 35.463  -24.712 -10.167 1.000 31.209 0 80   LEU A C   1 ? 
ATOM   501  O O   . LEU A 1 76  ? 35.793  -25.146 -11.274 1.000 27.961 0 80   LEU A O   1 ? 
ATOM   502  C CB  . LEU A 1 76  ? 35.879  -26.857 -8.933  1.000 28.680 0 80   LEU A CB  1 ? 
ATOM   503  C CG  . LEU A 1 76  ? 37.023  -27.685 -8.329  1.000 29.301 0 80   LEU A CG  1 ? 
ATOM   504  C CD1 . LEU A 1 76  ? 37.417  -27.208 -6.929  1.000 29.633 0 80   LEU A CD1 1 ? 
ATOM   505  C CD2 . LEU A 1 76  ? 36.642  -29.162 -8.280  1.000 28.514 0 80   LEU A CD2 1 ? 
ATOM   506  N N   . GLY A 1 77  ? 34.589  -23.715 -10.014 1.000 30.104 0 81   GLY A N   1 ? 
ATOM   507  C CA  . GLY A 1 77  ? 34.073  -22.939 -11.125 1.000 30.398 0 81   GLY A CA  1 ? 
ATOM   508  C C   . GLY A 1 77  ? 32.621  -23.181 -11.481 1.000 30.390 0 81   GLY A C   1 ? 
ATOM   509  O O   . GLY A 1 77  ? 32.096  -22.479 -12.353 1.000 33.796 0 81   GLY A O   1 ? 
ATOM   510  N N   . ALA A 1 78  ? 31.950  -24.138 -10.846 1.000 29.430 0 82   ALA A N   1 ? 
ATOM   511  C CA  . ALA A 1 78  ? 30.577  -24.453 -11.216 1.000 28.659 0 82   ALA A CA  1 ? 
ATOM   512  C C   . ALA A 1 78  ? 29.604  -23.386 -10.721 1.000 31.201 0 82   ALA A C   1 ? 
ATOM   513  O O   . ALA A 1 78  ? 29.855  -22.683 -9.737  1.000 31.941 0 82   ALA A O   1 ? 
ATOM   514  C CB  . ALA A 1 78  ? 30.162  -25.817 -10.649 1.000 28.243 0 82   ALA A CB  1 ? 
ATOM   515  N N   . GLU A 1 79  ? 28.487  -23.261 -11.433 1.000 32.720 0 83   GLU A N   1 ? 
ATOM   516  C CA  . GLU A 1 79  ? 27.283  -22.640 -10.903 1.000 29.846 0 83   GLU A CA  1 ? 
ATOM   517  C C   . GLU A 1 79  ? 26.284  -23.742 -10.587 1.000 30.338 0 83   GLU A C   1 ? 
ATOM   518  O O   . GLU A 1 79  ? 26.148  -24.698 -11.353 1.000 32.820 0 83   GLU A O   1 ? 
ATOM   519  C CB  . GLU A 1 79  ? 26.684  -21.646 -11.898 1.000 33.349 0 83   GLU A CB  1 ? 
ATOM   520  C CG  . GLU A 1 79  ? 27.545  -20.406 -12.080 1.000 35.191 0 83   GLU A CG  1 ? 
ATOM   521  C CD  . GLU A 1 79  ? 27.140  -19.579 -13.288 1.000 44.863 0 83   GLU A CD  1 ? 
ATOM   522  O OE1 . GLU A 1 79  ? 26.106  -19.896 -13.916 1.000 42.713 0 83   GLU A OE1 1 ? 
ATOM   523  O OE2 . GLU A 1 79  ? 27.862  -18.612 -13.612 1.000 48.293 0 83   GLU A OE2 1 ? 
ATOM   524  N N   . VAL A 1 80  ? 25.615  -23.635 -9.440  1.000 30.775 0 84   VAL A N   1 ? 
ATOM   525  C CA  . VAL A 1 80  ? 24.682  -24.675 -9.027  1.000 28.017 0 84   VAL A CA  1 ? 
ATOM   526  C C   . VAL A 1 80  ? 23.351  -24.061 -8.605  1.000 30.393 0 84   VAL A C   1 ? 
ATOM   527  O O   . VAL A 1 80  ? 23.247  -22.873 -8.292  1.000 32.633 0 84   VAL A O   1 ? 
ATOM   528  C CB  . VAL A 1 80  ? 25.247  -25.565 -7.889  1.000 31.646 0 84   VAL A CB  1 ? 
ATOM   529  C CG1 . VAL A 1 80  ? 26.698  -25.948 -8.166  1.000 34.162 0 84   VAL A CG1 1 ? 
ATOM   530  C CG2 . VAL A 1 80  ? 25.124  -24.870 -6.547  1.000 34.396 0 84   VAL A CG2 1 ? 
ATOM   531  N N   . ARG A 1 81  ? 22.317  -24.899 -8.639  1.000 30.988 0 85   ARG A N   1 ? 
ATOM   532  C CA  . ARG A 1 81  ? 21.027  -24.628 -8.022  1.000 27.556 0 85   ARG A CA  1 ? 
ATOM   533  C C   . ARG A 1 81  ? 20.674  -25.891 -7.259  1.000 28.119 0 85   ARG A C   1 ? 
ATOM   534  O O   . ARG A 1 81  ? 20.813  -26.988 -7.804  1.000 28.564 0 85   ARG A O   1 ? 
ATOM   535  C CB  . ARG A 1 81  ? 19.948  -24.298 -9.060  1.000 27.477 0 85   ARG A CB  1 ? 
ATOM   536  C CG  . ARG A 1 81  ? 20.224  -23.055 -9.904  1.000 28.953 0 85   ARG A CG  1 ? 
ATOM   537  C CD  . ARG A 1 81  ? 19.071  -22.777 -10.876 1.000 29.443 0 85   ARG A CD  1 ? 
ATOM   538  N NE  . ARG A 1 81  ? 17.871  -22.254 -10.224 1.000 30.930 0 85   ARG A NE  1 ? 
ATOM   539  C CZ  . ARG A 1 81  ? 17.727  -21.002 -9.798  1.000 34.625 0 85   ARG A CZ  1 ? 
ATOM   540  N NH1 . ARG A 1 81  ? 18.715  -20.124 -9.940  1.000 34.091 0 85   ARG A NH1 1 ? 
ATOM   541  N NH2 . ARG A 1 81  ? 16.591  -20.628 -9.225  1.000 33.580 0 85   ARG A NH2 1 ? 
ATOM   542  N N   . TRP A 1 82  ? 20.271  -25.756 -6.000  1.000 27.382 0 86   TRP A N   1 ? 
ATOM   543  C CA  . TRP A 1 82  ? 20.202  -26.915 -5.119  1.000 26.374 0 86   TRP A CA  1 ? 
ATOM   544  C C   . TRP A 1 82  ? 18.822  -27.106 -4.505  1.000 24.424 0 86   TRP A C   1 ? 
ATOM   545  O O   . TRP A 1 82  ? 18.107  -26.145 -4.216  1.000 26.027 0 86   TRP A O   1 ? 
ATOM   546  C CB  . TRP A 1 82  ? 21.225  -26.812 -3.983  1.000 27.251 0 86   TRP A CB  1 ? 
ATOM   547  C CG  . TRP A 1 82  ? 21.807  -28.139 -3.609  1.000 25.614 0 86   TRP A CG  1 ? 
ATOM   548  C CD1 . TRP A 1 82  ? 21.422  -28.950 -2.581  1.000 24.611 0 86   TRP A CD1 1 ? 
ATOM   549  C CD2 . TRP A 1 82  ? 22.887  -28.810 -4.269  1.000 26.314 0 86   TRP A CD2 1 ? 
ATOM   550  N NE1 . TRP A 1 82  ? 22.196  -30.089 -2.562  1.000 24.082 0 86   TRP A NE1 1 ? 
ATOM   551  C CE2 . TRP A 1 82  ? 23.105  -30.023 -3.587  1.000 25.327 0 86   TRP A CE2 1 ? 
ATOM   552  C CE3 . TRP A 1 82  ? 23.690  -28.500 -5.372  1.000 28.024 0 86   TRP A CE3 1 ? 
ATOM   553  C CZ2 . TRP A 1 82  ? 24.098  -30.929 -3.971  1.000 24.879 0 86   TRP A CZ2 1 ? 
ATOM   554  C CZ3 . TRP A 1 82  ? 24.676  -29.397 -5.752  1.000 26.490 0 86   TRP A CZ3 1 ? 
ATOM   555  C CH2 . TRP A 1 82  ? 24.868  -30.599 -5.054  1.000 24.666 0 86   TRP A CH2 1 ? 
ATOM   556  N N   . SER A 1 83  ? 18.490  -28.375 -4.267  1.000 25.140 0 87   SER A N   1 ? 
ATOM   557  C CA  . SER A 1 83  ? 17.325  -28.760 -3.484  1.000 26.490 0 87   SER A CA  1 ? 
ATOM   558  C C   . SER A 1 83  ? 17.702  -29.979 -2.659  1.000 24.490 0 87   SER A C   1 ? 
ATOM   559  O O   . SER A 1 83  ? 18.701  -30.649 -2.932  1.000 23.434 0 87   SER A O   1 ? 
ATOM   560  C CB  . SER A 1 83  ? 16.115  -29.078 -4.372  1.000 29.219 0 87   SER A CB  1 ? 
ATOM   561  O OG  . SER A 1 83  ? 16.371  -30.230 -5.162  1.000 29.067 0 87   SER A OG  1 ? 
ATOM   562  N N   . SER A 1 84  ? 16.903  -30.260 -1.638  1.000 23.792 0 88   SER A N   1 ? 
ATOM   563  C CA  . SER A 1 84  ? 17.089  -31.484 -0.868  1.000 23.132 0 88   SER A CA  1 ? 
ATOM   564  C C   . SER A 1 84  ? 16.329  -32.635 -1.519  1.000 27.298 0 88   SER A C   1 ? 
ATOM   565  O O   . SER A 1 84  ? 15.338  -32.433 -2.219  1.000 27.972 0 88   SER A O   1 ? 
ATOM   566  C CB  . SER A 1 84  ? 16.619  -31.302 0.576   1.000 28.377 0 88   SER A CB  1 ? 
ATOM   567  O OG  . SER A 1 84  ? 17.028  -32.404 1.376   1.000 27.682 0 88   SER A OG  1 ? 
ATOM   568  N N   . CYS A 1 85  ? 16.804  -33.858 -1.287  1.000 25.640 0 89   CYS A N   1 ? 
ATOM   569  C CA  . CYS A 1 85  ? 16.102  -35.038 -1.778  1.000 23.145 0 89   CYS A CA  1 ? 
ATOM   570  C C   . CYS A 1 85  ? 15.210  -35.675 -0.716  1.000 26.356 0 89   CYS A C   1 ? 
ATOM   571  O O   . CYS A 1 85  ? 14.750  -36.806 -0.907  1.000 25.314 0 89   CYS A O   1 ? 
ATOM   572  C CB  . CYS A 1 85  ? 17.101  -36.065 -2.326  1.000 22.790 0 89   CYS A CB  1 ? 
ATOM   573  S SG  . CYS A 1 85  ? 18.282  -36.731 -1.128  1.000 23.613 0 89   CYS A SG  1 ? 
ATOM   574  N N   . ASN A 1 86  ? 14.944  -34.980 0.388   1.000 25.895 0 90   ASN A N   1 ? 
ATOM   575  C CA  . ASN A 1 86  ? 14.010  -35.475 1.394   1.000 26.858 0 90   ASN A CA  1 ? 
ATOM   576  C C   . ASN A 1 86  ? 13.370  -34.296 2.115   1.000 24.808 0 90   ASN A C   1 ? 
ATOM   577  O O   . ASN A 1 86  ? 14.039  -33.295 2.390   1.000 26.914 0 90   ASN A O   1 ? 
ATOM   578  C CB  . ASN A 1 86  ? 14.709  -36.399 2.402   1.000 24.311 0 90   ASN A CB  1 ? 
ATOM   579  C CG  . ASN A 1 86  ? 13.726  -37.102 3.320   1.000 27.345 0 90   ASN A CG  1 ? 
ATOM   580  O OD1 . ASN A 1 86  ? 13.317  -36.557 4.349   1.000 26.050 0 90   ASN A OD1 1 ? 
ATOM   581  N ND2 . ASN A 1 86  ? 13.335  -38.316 2.949   1.000 26.582 0 90   ASN A ND2 1 ? 
ATOM   582  N N   . ILE A 1 87  ? 12.074  -34.427 2.428   1.000 26.303 0 91   ILE A N   1 ? 
ATOM   583  C CA  . ILE A 1 87  ? 11.338  -33.336 3.063   1.000 25.890 0 91   ILE A CA  1 ? 
ATOM   584  C C   . ILE A 1 87  ? 11.831  -33.018 4.466   1.000 27.414 0 91   ILE A C   1 ? 
ATOM   585  O O   . ILE A 1 87  ? 11.567  -31.918 4.961   1.000 28.506 0 91   ILE A O   1 ? 
ATOM   586  C CB  . ILE A 1 87  ? 9.824   -33.635 3.115   1.000 26.185 0 91   ILE A CB  1 ? 
ATOM   587  C CG1 . ILE A 1 87  ? 9.544   -34.885 3.960   1.000 28.127 0 91   ILE A CG1 1 ? 
ATOM   588  C CG2 . ILE A 1 87  ? 9.252   -33.762 1.706   1.000 28.143 0 91   ILE A CG2 1 ? 
ATOM   589  C CD1 . ILE A 1 87  ? 8.064   -35.082 4.282   1.000 28.295 0 91   ILE A CD1 1 ? 
ATOM   590  N N   . PHE A 1 88  ? 12.524  -33.941 5.137   1.000 25.377 0 92   PHE A N   1 ? 
ATOM   591  C CA  . PHE A 1 88  ? 12.963  -33.712 6.512   1.000 25.900 0 92   PHE A CA  1 ? 
ATOM   592  C C   . PHE A 1 88  ? 14.476  -33.610 6.670   1.000 27.337 0 92   PHE A C   1 ? 
ATOM   593  O O   . PHE A 1 88  ? 14.946  -33.370 7.788   1.000 27.664 0 92   PHE A O   1 ? 
ATOM   594  C CB  . PHE A 1 88  ? 12.462  -34.830 7.440   1.000 26.169 0 92   PHE A CB  1 ? 
ATOM   595  C CG  . PHE A 1 88  ? 10.969  -34.853 7.631   1.000 25.785 0 92   PHE A CG  1 ? 
ATOM   596  C CD1 . PHE A 1 88  ? 10.272  -33.702 7.955   1.000 27.682 0 92   PHE A CD1 1 ? 
ATOM   597  C CD2 . PHE A 1 88  ? 10.269  -36.044 7.502   1.000 27.880 0 92   PHE A CD2 1 ? 
ATOM   598  C CE1 . PHE A 1 88  ? 8.897   -33.741 8.132   1.000 31.967 0 92   PHE A CE1 1 ? 
ATOM   599  C CE2 . PHE A 1 88  ? 8.905   -36.092 7.677   1.000 28.680 0 92   PHE A CE2 1 ? 
ATOM   600  C CZ  . PHE A 1 88  ? 8.214   -34.941 7.993   1.000 34.559 0 92   PHE A CZ  1 ? 
ATOM   601  N N   . SER A 1 89  ? 15.258  -33.796 5.606   1.000 22.821 0 93   SER A N   1 ? 
ATOM   602  C CA  . SER A 1 89  ? 16.696  -33.936 5.796   1.000 22.692 0 93   SER A CA  1 ? 
ATOM   603  C C   . SER A 1 89  ? 17.458  -32.617 5.807   1.000 24.621 0 93   SER A C   1 ? 
ATOM   604  O O   . SER A 1 89  ? 18.631  -32.609 6.201   1.000 25.740 0 93   SER A O   1 ? 
ATOM   605  C CB  . SER A 1 89  ? 17.289  -34.837 4.716   1.000 22.387 0 93   SER A CB  1 ? 
ATOM   606  O OG  . SER A 1 89  ? 17.065  -34.281 3.434   1.000 23.550 0 93   SER A OG  1 ? 
ATOM   607  N N   . THR A 1 90  ? 16.847  -31.511 5.388   1.000 23.711 0 94   THR A N   1 ? 
ATOM   608  C CA  . THR A 1 90  ? 17.565  -30.247 5.392   1.000 25.364 0 94   THR A CA  1 ? 
ATOM   609  C C   . THR A 1 90  ? 17.926  -29.831 6.814   1.000 24.635 0 94   THR A C   1 ? 
ATOM   610  O O   . THR A 1 90  ? 17.133  -29.983 7.749   1.000 27.161 0 94   THR A O   1 ? 
ATOM   611  C CB  . THR A 1 90  ? 16.718  -29.155 4.727   1.000 26.169 0 94   THR A CB  1 ? 
ATOM   612  O OG1 . THR A 1 90  ? 16.588  -29.443 3.332   1.000 26.269 0 94   THR A OG1 1 ? 
ATOM   613  C CG2 . THR A 1 90  ? 17.359  -27.771 4.878   1.000 27.940 0 94   THR A CG2 1 ? 
ATOM   614  N N   . GLN A 1 91  ? 19.145  -29.325 6.971   1.000 24.521 0 95   GLN A N   1 ? 
ATOM   615  C CA  . GLN A 1 91  ? 19.542  -28.562 8.145   1.000 25.487 0 95   GLN A CA  1 ? 
ATOM   616  C C   . GLN A 1 91  ? 19.394  -27.095 7.776   1.000 25.474 0 95   GLN A C   1 ? 
ATOM   617  O O   . GLN A 1 91  ? 20.138  -26.589 6.933   1.000 27.806 0 95   GLN A O   1 ? 
ATOM   618  C CB  . GLN A 1 91  ? 20.975  -28.872 8.548   1.000 25.021 0 95   GLN A CB  1 ? 
ATOM   619  C CG  . GLN A 1 91  ? 21.164  -30.246 9.115   1.000 29.901 0 95   GLN A CG  1 ? 
ATOM   620  C CD  . GLN A 1 91  ? 22.580  -30.424 9.573   1.000 35.883 0 95   GLN A CD  1 ? 
ATOM   621  O OE1 . GLN A 1 91  ? 23.464  -30.624 8.762   1.000 28.946 0 95   GLN A OE1 1 ? 
ATOM   622  N NE2 . GLN A 1 91  ? 22.814  -30.300 10.880  1.000 44.771 0 95   GLN A NE2 1 ? 
ATOM   623  N N   . ASP A 1 92  ? 18.435  -26.416 8.410   1.000 28.753 0 96   ASP A N   1 ? 
ATOM   624  C CA  . ASP A 1 92  ? 18.089  -25.068 7.979   1.000 27.909 0 96   ASP A CA  1 ? 
ATOM   625  C C   . ASP A 1 92  ? 19.288  -24.135 8.055   1.000 30.885 0 96   ASP A C   1 ? 
ATOM   626  O O   . ASP A 1 92  ? 19.460  -23.272 7.187   1.000 31.235 0 96   ASP A O   1 ? 
ATOM   627  C CB  . ASP A 1 92  ? 16.926  -24.525 8.809   1.000 30.159 0 96   ASP A CB  1 ? 
ATOM   628  C CG  . ASP A 1 92  ? 15.599  -25.188 8.463   1.000 31.627 0 96   ASP A CG  1 ? 
ATOM   629  O OD1 . ASP A 1 92  ? 15.430  -25.674 7.316   1.000 29.082 0 96   ASP A OD1 1 ? 
ATOM   630  O OD2 . ASP A 1 92  ? 14.716  -25.212 9.346   1.000 33.872 0 96   ASP A OD2 1 ? 
ATOM   631  N N   . HIS A 1 93  ? 20.150  -24.300 9.066   1.000 28.048 0 97   HIS A N   1 ? 
ATOM   632  C CA  . HIS A 1 93  ? 21.276  -23.373 9.158   1.000 30.380 0 97   HIS A CA  1 ? 
ATOM   633  C C   . HIS A 1 93  ? 22.316  -23.647 8.080   1.000 32.583 0 97   HIS A C   1 ? 
ATOM   634  O O   . HIS A 1 93  ? 23.029  -22.726 7.665   1.000 31.225 0 97   HIS A O   1 ? 
ATOM   635  C CB  . HIS A 1 93  ? 21.900  -23.389 10.560  1.000 29.561 0 97   HIS A CB  1 ? 
ATOM   636  C CG  . HIS A 1 93  ? 22.448  -24.714 10.995  1.000 30.172 0 97   HIS A CG  1 ? 
ATOM   637  N ND1 . HIS A 1 93  ? 21.654  -25.822 11.204  1.000 30.101 0 97   HIS A ND1 1 ? 
ATOM   638  C CD2 . HIS A 1 93  ? 23.707  -25.087 11.325  1.000 26.806 0 97   HIS A CD2 1 ? 
ATOM   639  C CE1 . HIS A 1 93  ? 22.407  -26.831 11.608  1.000 32.996 0 97   HIS A CE1 1 ? 
ATOM   640  N NE2 . HIS A 1 93  ? 23.657  -26.411 11.691  1.000 28.727 0 97   HIS A NE2 1 ? 
ATOM   641  N N   . ALA A 1 94  ? 22.403  -24.887 7.590   1.000 26.680 0 98   ALA A N   1 ? 
ATOM   642  C CA  . ALA A 1 94  ? 23.254  -25.142 6.432   1.000 27.198 0 98   ALA A CA  1 ? 
ATOM   643  C C   . ALA A 1 94  ? 22.676  -24.502 5.176   1.000 28.925 0 98   ALA A C   1 ? 
ATOM   644  O O   . ALA A 1 94  ? 23.409  -23.879 4.396   1.000 30.030 0 98   ALA A O   1 ? 
ATOM   645  C CB  . ALA A 1 94  ? 23.431  -26.642 6.222   1.000 27.322 0 98   ALA A CB  1 ? 
ATOM   646  N N   . ALA A 1 95  ? 21.363  -24.644 4.962   1.000 27.498 0 99   ALA A N   1 ? 
ATOM   647  C CA  . ALA A 1 95  ? 20.740  -24.013 3.800   1.000 23.798 0 99   ALA A CA  1 ? 
ATOM   648  C C   . ALA A 1 95  ? 20.911  -22.501 3.833   1.000 30.435 0 99   ALA A C   1 ? 
ATOM   649  O O   . ALA A 1 95  ? 21.151  -21.872 2.797   1.000 29.622 0 99   ALA A O   1 ? 
ATOM   650  C CB  . ALA A 1 95  ? 19.258  -24.384 3.733   1.000 26.914 0 99   ALA A CB  1 ? 
ATOM   651  N N   . SER A 1 96  ? 20.789  -21.898 5.015   1.000 29.948 0 100  SER A N   1 ? 
ATOM   652  C CA  . SER A 1 96  ? 20.929  -20.450 5.112   1.000 29.564 0 100  SER A CA  1 ? 
ATOM   653  C C   . SER A 1 96  ? 22.351  -20.011 4.797   1.000 31.917 0 100  SER A C   1 ? 
ATOM   654  O O   . SER A 1 96  ? 22.552  -18.981 4.145   1.000 32.038 0 100  SER A O   1 ? 
ATOM   655  C CB  . SER A 1 96  ? 20.517  -19.972 6.505   1.000 33.870 0 100  SER A CB  1 ? 
ATOM   656  O OG  . SER A 1 96  ? 19.136  -20.191 6.728   1.000 35.088 0 100  SER A OG  1 ? 
ATOM   657  N N   . ALA A 1 97  ? 23.353  -20.765 5.262   1.000 28.619 0 101  ALA A N   1 ? 
ATOM   658  C CA  . ALA A 1 97  ? 24.732  -20.405 4.940   1.000 31.543 0 101  ALA A CA  1 ? 
ATOM   659  C C   . ALA A 1 97  ? 24.960  -20.400 3.432   1.000 32.120 0 101  ALA A C   1 ? 
ATOM   660  O O   . ALA A 1 97  ? 25.628  -19.505 2.896   1.000 31.701 0 101  ALA A O   1 ? 
ATOM   661  C CB  . ALA A 1 97  ? 25.704  -21.362 5.631   1.000 32.809 0 101  ALA A CB  1 ? 
ATOM   662  N N   . ILE A 1 98  ? 24.401  -21.390 2.731   1.000 30.875 0 102  ILE A N   1 ? 
ATOM   663  C CA  . ILE A 1 98  ? 24.520  -21.450 1.277   1.000 29.585 0 102  ILE A CA  1 ? 
ATOM   664  C C   . ILE A 1 98  ? 23.770  -20.288 0.631   1.000 31.709 0 102  ILE A C   1 ? 
ATOM   665  O O   . ILE A 1 98  ? 24.293  -19.611 -0.263  1.000 30.306 0 102  ILE A O   1 ? 
ATOM   666  C CB  . ILE A 1 98  ? 24.019  -22.817 0.770   1.000 27.427 0 102  ILE A CB  1 ? 
ATOM   667  C CG1 . ILE A 1 98  ? 24.991  -23.930 1.185   1.000 27.677 0 102  ILE A CG1 1 ? 
ATOM   668  C CG2 . ILE A 1 98  ? 23.820  -22.815 -0.739  1.000 28.403 0 102  ILE A CG2 1 ? 
ATOM   669  C CD1 . ILE A 1 98  ? 26.408  -23.741 0.649   1.000 28.361 0 102  ILE A CD1 1 ? 
ATOM   670  N N   . ALA A 1 99  ? 22.541  -20.025 1.086   1.000 29.080 0 103  ALA A N   1 ? 
ATOM   671  C CA  . ALA A 1 99  ? 21.763  -18.925 0.516   1.000 29.346 0 103  ALA A CA  1 ? 
ATOM   672  C C   . ALA A 1 99  ? 22.453  -17.584 0.731   1.000 34.670 0 103  ALA A C   1 ? 
ATOM   673  O O   . ALA A 1 99  ? 22.411  -16.705 -0.142  1.000 35.699 0 103  ALA A O   1 ? 
ATOM   674  C CB  . ALA A 1 99  ? 20.359  -18.896 1.122   1.000 31.254 0 103  ALA A CB  1 ? 
ATOM   675  N N   . ALA A 1 100 ? 23.091  -17.407 1.892   1.000 36.520 0 104  ALA A N   1 ? 
ATOM   676  C CA  . ALA A 1 100 ? 23.769  -16.147 2.182   1.000 38.876 0 104  ALA A CA  1 ? 
ATOM   677  C C   . ALA A 1 100 ? 24.959  -15.919 1.259   1.000 36.694 0 104  ALA A C   1 ? 
ATOM   678  O O   . ALA A 1 100 ? 25.348  -14.771 1.030   1.000 39.415 0 104  ALA A O   1 ? 
ATOM   679  C CB  . ALA A 1 100 ? 24.215  -16.111 3.644   1.000 38.497 0 104  ALA A CB  1 ? 
ATOM   680  N N   . LYS A 1 101 ? 25.554  -16.989 0.732   1.000 35.549 0 105  LYS A N   1 ? 
ATOM   681  C CA  . LYS A 1 101 ? 26.627  -16.870 -0.249  1.000 34.199 0 105  LYS A CA  1 ? 
ATOM   682  C C   . LYS A 1 101 ? 26.118  -16.479 -1.623  1.000 38.565 0 105  LYS A C   1 ? 
ATOM   683  O O   . LYS A 1 101 ? 26.929  -16.297 -2.537  1.000 44.118 0 105  LYS A O   1 ? 
ATOM   684  C CB  . LYS A 1 101 ? 27.400  -18.190 -0.354  1.000 37.347 0 105  LYS A CB  1 ? 
ATOM   685  C CG  . LYS A 1 101 ? 28.387  -18.437 0.775   1.000 44.690 0 105  LYS A CG  1 ? 
ATOM   686  C CD  . LYS A 1 101 ? 29.586  -17.503 0.690   1.000 50.253 0 105  LYS A CD  1 ? 
ATOM   687  C CE  . LYS A 1 101 ? 30.786  -18.079 1.427   1.000 54.986 0 105  LYS A CE  1 ? 
ATOM   688  N NZ  . LYS A 1 101 ? 31.793  -17.027 1.756   1.000 57.662 0 105  LYS A NZ  1 ? 
ATOM   689  N N   . GLY A 1 102 ? 24.804  -16.354 -1.792  1.000 36.618 0 106  GLY A N   1 ? 
ATOM   690  C CA  . GLY A 1 102 ? 24.244  -16.071 -3.098  1.000 37.533 0 106  GLY A CA  1 ? 
ATOM   691  C C   . GLY A 1 102 ? 24.091  -17.283 -3.982  1.000 37.491 0 106  GLY A C   1 ? 
ATOM   692  O O   . GLY A 1 102 ? 23.923  -17.135 -5.196  1.000 41.026 0 106  GLY A O   1 ? 
ATOM   693  N N   . ILE A 1 103 ? 24.154  -18.482 -3.411  1.000 32.530 0 107  ILE A N   1 ? 
ATOM   694  C CA  . ILE A 1 103 ? 23.983  -19.716 -4.171  1.000 32.759 0 107  ILE A CA  1 ? 
ATOM   695  C C   . ILE A 1 103 ? 22.503  -20.079 -4.124  1.000 34.136 0 107  ILE A C   1 ? 
ATOM   696  O O   . ILE A 1 103 ? 21.919  -20.111 -3.032  1.000 35.757 0 107  ILE A O   1 ? 
ATOM   697  C CB  . ILE A 1 103 ? 24.867  -20.838 -3.604  1.000 31.572 0 107  ILE A CB  1 ? 
ATOM   698  C CG1 . ILE A 1 103 ? 26.346  -20.471 -3.735  1.000 31.420 0 107  ILE A CG1 1 ? 
ATOM   699  C CG2 . ILE A 1 103 ? 24.577  -22.156 -4.296  1.000 31.693 0 107  ILE A CG2 1 ? 
ATOM   700  C CD1 . ILE A 1 103 ? 27.256  -21.309 -2.856  1.000 33.188 0 107  ILE A CD1 1 ? 
ATOM   701  N N   . PRO A 1 104 ? 21.845  -20.319 -5.262  1.000 33.057 0 108  PRO A N   1 ? 
ATOM   702  C CA  . PRO A 1 104 ? 20.407  -20.632 -5.223  1.000 31.459 0 108  PRO A CA  1 ? 
ATOM   703  C C   . PRO A 1 104 ? 20.171  -21.986 -4.568  1.000 31.880 0 108  PRO A C   1 ? 
ATOM   704  O O   . PRO A 1 104 ? 20.689  -23.010 -5.019  1.000 32.717 0 108  PRO A O   1 ? 
ATOM   705  C CB  . PRO A 1 104 ? 19.995  -20.627 -6.703  1.000 30.454 0 108  PRO A CB  1 ? 
ATOM   706  C CG  . PRO A 1 104 ? 21.059  -19.799 -7.396  1.000 31.267 0 108  PRO A CG  1 ? 
ATOM   707  C CD  . PRO A 1 104 ? 22.327  -20.132 -6.644  1.000 32.746 0 108  PRO A CD  1 ? 
ATOM   708  N N   . VAL A 1 105 ? 19.412  -21.975 -3.479  1.000 30.098 0 109  VAL A N   1 ? 
ATOM   709  C CA  . VAL A 1 105 ? 19.079  -23.181 -2.733  1.000 28.364 0 109  VAL A CA  1 ? 
ATOM   710  C C   . VAL A 1 105 ? 17.616  -23.078 -2.337  1.000 33.057 0 109  VAL A C   1 ? 
ATOM   711  O O   . VAL A 1 105 ? 17.145  -22.009 -1.933  1.000 31.430 0 109  VAL A O   1 ? 
ATOM   712  C CB  . VAL A 1 105 ? 19.994  -23.372 -1.501  1.000 29.651 0 109  VAL A CB  1 ? 
ATOM   713  C CG1 . VAL A 1 105 ? 19.987  -22.134 -0.612  1.000 30.467 0 109  VAL A CG1 1 ? 
ATOM   714  C CG2 . VAL A 1 105 ? 19.600  -24.619 -0.709  1.000 28.582 0 109  VAL A CG2 1 ? 
ATOM   715  N N   . PHE A 1 106 ? 16.892  -24.187 -2.483  1.000 30.011 0 110  PHE A N   1 ? 
ATOM   716  C CA  . PHE A 1 106 ? 15.454  -24.252 -2.237  1.000 29.153 0 110  PHE A CA  1 ? 
ATOM   717  C C   . PHE A 1 106 ? 15.236  -25.463 -1.338  1.000 30.675 0 110  PHE A C   1 ? 
ATOM   718  O O   . PHE A 1 106 ? 15.118  -26.595 -1.818  1.000 30.909 0 110  PHE A O   1 ? 
ATOM   719  C CB  . PHE A 1 106 ? 14.696  -24.336 -3.557  1.000 29.996 0 110  PHE A CB  1 ? 
ATOM   720  C CG  . PHE A 1 106 ? 15.005  -23.193 -4.486  1.000 32.959 0 110  PHE A CG  1 ? 
ATOM   721  C CD1 . PHE A 1 106 ? 16.088  -23.254 -5.351  1.000 33.496 0 110  PHE A CD1 1 ? 
ATOM   722  C CD2 . PHE A 1 106 ? 14.241  -22.039 -4.459  1.000 33.999 0 110  PHE A CD2 1 ? 
ATOM   723  C CE1 . PHE A 1 106 ? 16.389  -22.187 -6.183  1.000 32.096 0 110  PHE A CE1 1 ? 
ATOM   724  C CE2 . PHE A 1 106 ? 14.536  -20.975 -5.287  1.000 37.418 0 110  PHE A CE2 1 ? 
ATOM   725  C CZ  . PHE A 1 106 ? 15.609  -21.050 -6.150  1.000 33.662 0 110  PHE A CZ  1 ? 
ATOM   726  N N   . ALA A 1 107 ? 15.223  -25.223 -0.025  1.000 29.101 0 111  ALA A N   1 ? 
ATOM   727  C CA  . ALA A 1 107 ? 15.310  -26.320 0.934   1.000 26.474 0 111  ALA A CA  1 ? 
ATOM   728  C C   . ALA A 1 107 ? 15.025  -25.861 2.357   1.000 27.469 0 111  ALA A C   1 ? 
ATOM   729  O O   . ALA A 1 107 ? 15.591  -24.868 2.825   1.000 29.769 0 111  ALA A O   1 ? 
ATOM   730  C CB  . ALA A 1 107 ? 16.696  -26.972 0.880   1.000 26.835 0 111  ALA A CB  1 ? 
ATOM   731  N N   . TRP A 1 108 ? 14.152  -26.583 3.054   1.000 27.201 0 112  TRP A N   1 ? 
ATOM   732  C CA  . TRP A 1 108 ? 13.949  -26.375 4.478   1.000 28.961 0 112  TRP A CA  1 ? 
ATOM   733  C C   . TRP A 1 108 ? 13.476  -27.682 5.094   1.000 27.917 0 112  TRP A C   1 ? 
ATOM   734  O O   . TRP A 1 108 ? 12.960  -28.566 4.404   1.000 28.314 0 112  TRP A O   1 ? 
ATOM   735  C CB  . TRP A 1 108 ? 12.950  -25.239 4.761   1.000 30.019 0 112  TRP A CB  1 ? 
ATOM   736  C CG  . TRP A 1 108 ? 11.608  -25.355 4.084   1.000 29.754 0 112  TRP A CG  1 ? 
ATOM   737  C CD1 . TRP A 1 108 ? 10.450  -25.837 4.633   1.000 31.075 0 112  TRP A CD1 1 ? 
ATOM   738  C CD2 . TRP A 1 108 ? 11.275  -24.941 2.751   1.000 31.972 0 112  TRP A CD2 1 ? 
ATOM   739  N NE1 . TRP A 1 108 ? 9.424   -25.760 3.720   1.000 33.130 0 112  TRP A NE1 1 ? 
ATOM   740  C CE2 . TRP A 1 108 ? 9.904   -25.214 2.557   1.000 34.780 0 112  TRP A CE2 1 ? 
ATOM   741  C CE3 . TRP A 1 108 ? 12.004  -24.372 1.700   1.000 31.551 0 112  TRP A CE3 1 ? 
ATOM   742  C CZ2 . TRP A 1 108 ? 9.250   -24.943 1.354   1.000 33.662 0 112  TRP A CZ2 1 ? 
ATOM   743  C CZ3 . TRP A 1 108 ? 11.351  -24.101 0.505   1.000 34.738 0 112  TRP A CZ3 1 ? 
ATOM   744  C CH2 . TRP A 1 108 ? 9.987   -24.386 0.344   1.000 35.760 0 112  TRP A CH2 1 ? 
ATOM   745  N N   . LYS A 1 109 ? 13.671  -27.806 6.401   1.000 29.146 0 113  LYS A N   1 ? 
ATOM   746  C CA  . LYS A 1 109 ? 13.217  -28.996 7.107   1.000 28.269 0 113  LYS A CA  1 ? 
ATOM   747  C C   . LYS A 1 109 ? 11.707  -28.926 7.289   1.000 33.186 0 113  LYS A C   1 ? 
ATOM   748  O O   . LYS A 1 109 ? 11.175  -27.901 7.726   1.000 33.862 0 113  LYS A O   1 ? 
ATOM   749  C CB  . LYS A 1 109 ? 13.917  -29.116 8.461   1.000 25.587 0 113  LYS A CB  1 ? 
ATOM   750  C CG  . LYS A 1 109 ? 13.741  -30.474 9.145   1.000 28.051 0 113  LYS A CG  1 ? 
ATOM   751  C CD  . LYS A 1 109 ? 14.460  -30.503 10.497  1.000 30.651 0 113  LYS A CD  1 ? 
ATOM   752  C CE  . LYS A 1 109 ? 14.452  -31.894 11.132  1.000 28.409 0 113  LYS A CE  1 ? 
ATOM   753  N NZ  . LYS A 1 109 ? 15.414  -32.818 10.464  1.000 30.212 0 113  LYS A NZ  1 ? 
ATOM   754  N N   . GLY A 1 110 ? 11.014  -30.007 6.939   1.000 27.730 0 114  GLY A N   1 ? 
ATOM   755  C CA  . GLY A 1 110 ? 9.572   -30.039 7.088   1.000 31.080 0 114  GLY A CA  1 ? 
ATOM   756  C C   . GLY A 1 110 ? 8.785   -29.572 5.885   1.000 30.914 0 114  GLY A C   1 ? 
ATOM   757  O O   . GLY A 1 110 ? 7.684   -29.030 6.050   1.000 31.638 0 114  GLY A O   1 ? 
ATOM   758  N N   . GLU A 1 111 ? 9.309   -29.765 4.677   1.000 30.562 0 115  GLU A N   1 ? 
ATOM   759  C CA  . GLU A 1 111 ? 8.561   -29.433 3.474   1.000 31.151 0 115  GLU A CA  1 ? 
ATOM   760  C C   . GLU A 1 111 ? 7.323   -30.314 3.356   1.000 30.301 0 115  GLU A C   1 ? 
ATOM   761  O O   . GLU A 1 111 ? 7.303   -31.457 3.823   1.000 29.722 0 115  GLU A O   1 ? 
ATOM   762  C CB  . GLU A 1 111 ? 9.439   -29.617 2.233   1.000 30.727 0 115  GLU A CB  1 ? 
ATOM   763  C CG  . GLU A 1 111 ? 10.698  -28.766 2.227   1.000 31.527 0 115  GLU A CG  1 ? 
ATOM   764  C CD  . GLU A 1 111 ? 11.723  -29.236 1.212   1.000 34.515 0 115  GLU A CD  1 ? 
ATOM   765  O OE1 . GLU A 1 111 ? 12.797  -28.600 1.114   1.000 30.630 0 115  GLU A OE1 1 ? 
ATOM   766  O OE2 . GLU A 1 111 ? 11.462  -30.240 0.514   1.000 33.675 0 115  GLU A OE2 1 ? 
ATOM   767  N N   . THR A 1 112 ? 6.277   -29.766 2.738   1.000 32.428 0 116  THR A N   1 ? 
ATOM   768  C CA  . THR A 1 112 ? 5.210   -30.610 2.227   1.000 32.325 0 116  THR A CA  1 ? 
ATOM   769  C C   . THR A 1 112 ? 5.663   -31.277 0.931   1.000 31.191 0 116  THR A C   1 ? 
ATOM   770  O O   . THR A 1 112 ? 6.664   -30.889 0.320   1.000 33.570 0 116  THR A O   1 ? 
ATOM   771  C CB  . THR A 1 112 ? 3.937   -29.799 1.982   1.000 32.162 0 116  THR A CB  1 ? 
ATOM   772  O OG1 . THR A 1 112 ? 4.138   -28.926 0.864   1.000 36.083 0 116  THR A OG1 1 ? 
ATOM   773  C CG2 . THR A 1 112 ? 3.583   -28.968 3.212   1.000 32.828 0 116  THR A CG2 1 ? 
ATOM   774  N N   . GLU A 1 113 ? 4.917   -32.297 0.499   1.000 31.933 0 117  GLU A N   1 ? 
ATOM   775  C CA  . GLU A 1 113 ? 5.275   -32.948 -0.757  1.000 33.378 0 117  GLU A CA  1 ? 
ATOM   776  C C   . GLU A 1 113 ? 5.179   -31.975 -1.925  1.000 34.370 0 117  GLU A C   1 ? 
ATOM   777  O O   . GLU A 1 113 ? 6.032   -31.988 -2.821  1.000 31.004 0 117  GLU A O   1 ? 
ATOM   778  C CB  . GLU A 1 113 ? 4.399   -34.174 -1.004  1.000 35.186 0 117  GLU A CB  1 ? 
ATOM   779  C CG  . GLU A 1 113 ? 4.508   -35.254 0.073   1.000 32.407 0 117  GLU A CG  1 ? 
ATOM   780  C CD  . GLU A 1 113 ? 5.911   -35.824 0.228   1.000 35.654 0 117  GLU A CD  1 ? 
ATOM   781  O OE1 . GLU A 1 113 ? 6.309   -36.084 1.384   1.000 35.170 0 117  GLU A OE1 1 ? 
ATOM   782  O OE2 . GLU A 1 113 ? 6.611   -36.021 -0.794  1.000 35.578 0 117  GLU A OE2 1 ? 
ATOM   783  N N   . GLU A 1 114 ? 4.150   -31.117 -1.933  1.000 34.641 0 118  GLU A N   1 ? 
ATOM   784  C CA  . GLU A 1 114 ? 4.054   -30.116 -2.993  1.000 31.246 0 118  GLU A CA  1 ? 
ATOM   785  C C   . GLU A 1 114 ? 5.254   -29.181 -2.966  1.000 32.585 0 118  GLU A C   1 ? 
ATOM   786  O O   . GLU A 1 114 ? 5.806   -28.840 -4.018  1.000 33.457 0 118  GLU A O   1 ? 
ATOM   787  C CB  . GLU A 1 114 ? 2.747   -29.320 -2.873  1.000 34.462 0 118  GLU A CB  1 ? 
ATOM   788  C CG  . GLU A 1 114 ? 2.616   -28.224 -3.934  1.000 41.692 0 118  GLU A CG  1 ? 
ATOM   789  C CD  . GLU A 1 114 ? 1.365   -27.367 -3.775  1.000 55.654 0 118  GLU A CD  1 ? 
ATOM   790  O OE1 . GLU A 1 114 ? 0.387   -27.830 -3.148  1.000 55.228 0 118  GLU A OE1 1 ? 
ATOM   791  O OE2 . GLU A 1 114 ? 1.357   -26.230 -4.293  1.000 58.720 0 118  GLU A OE2 1 ? 
ATOM   792  N N   . GLU A 1 115 ? 5.679   -28.767 -1.771  1.000 33.049 0 119  GLU A N   1 ? 
ATOM   793  C CA  . GLU A 1 115 ? 6.851   -27.902 -1.666  1.000 34.338 0 119  GLU A CA  1 ? 
ATOM   794  C C   . GLU A 1 115 ? 8.101   -28.627 -2.135  1.000 30.748 0 119  GLU A C   1 ? 
ATOM   795  O O   . GLU A 1 115 ? 8.946   -28.043 -2.823  1.000 32.228 0 119  GLU A O   1 ? 
ATOM   796  C CB  . GLU A 1 115 ? 7.025   -27.417 -0.223  1.000 34.320 0 119  GLU A CB  1 ? 
ATOM   797  C CG  . GLU A 1 115 ? 6.045   -26.312 0.171   1.000 35.020 0 119  GLU A CG  1 ? 
ATOM   798  C CD  . GLU A 1 115 ? 5.946   -26.102 1.675   1.000 38.926 0 119  GLU A CD  1 ? 
ATOM   799  O OE1 . GLU A 1 115 ? 6.512   -26.904 2.441   1.000 36.941 0 119  GLU A OE1 1 ? 
ATOM   800  O OE2 . GLU A 1 115 ? 5.283   -25.129 2.095   1.000 40.350 0 119  GLU A OE2 1 ? 
ATOM   801  N N   . TYR A 1 116 ? 8.228   -29.907 -1.772  1.000 28.696 0 120  TYR A N   1 ? 
ATOM   802  C CA  . TYR A 1 116 ? 9.381   -30.702 -2.180  1.000 27.769 0 120  TYR A CA  1 ? 
ATOM   803  C C   . TYR A 1 116 ? 9.576   -30.664 -3.691  1.000 32.612 0 120  TYR A C   1 ? 
ATOM   804  O O   . TYR A 1 116 ? 10.665  -30.352 -4.183  1.000 31.067 0 120  TYR A O   1 ? 
ATOM   805  C CB  . TYR A 1 116 ? 9.209   -32.143 -1.702  1.000 27.488 0 120  TYR A CB  1 ? 
ATOM   806  C CG  . TYR A 1 116 ? 10.276  -33.073 -2.226  1.000 26.482 0 120  TYR A CG  1 ? 
ATOM   807  C CD1 . TYR A 1 116 ? 11.482  -33.221 -1.550  1.000 24.814 0 120  TYR A CD1 1 ? 
ATOM   808  C CD2 . TYR A 1 116 ? 10.087  -33.796 -3.402  1.000 27.719 0 120  TYR A CD2 1 ? 
ATOM   809  C CE1 . TYR A 1 116 ? 12.462  -34.065 -2.022  1.000 25.987 0 120  TYR A CE1 1 ? 
ATOM   810  C CE2 . TYR A 1 116 ? 11.076  -34.646 -3.887  1.000 26.840 0 120  TYR A CE2 1 ? 
ATOM   811  C CZ  . TYR A 1 116 ? 12.258  -34.770 -3.189  1.000 29.080 0 120  TYR A CZ  1 ? 
ATOM   812  O OH  . TYR A 1 116 ? 13.255  -35.608 -3.647  1.000 25.585 0 120  TYR A OH  1 ? 
ATOM   813  N N   . TRP A 1 117 ? 8.524   -30.986 -4.447  1.000 31.346 0 121  TRP A N   1 ? 
ATOM   814  C CA  . TRP A 1 117 ? 8.670   -31.036 -5.897  1.000 30.730 0 121  TRP A CA  1 ? 
ATOM   815  C C   . TRP A 1 117 ? 8.818   -29.643 -6.492  1.000 33.678 0 121  TRP A C   1 ? 
ATOM   816  O O   . TRP A 1 117 ? 9.520   -29.476 -7.498  1.000 32.333 0 121  TRP A O   1 ? 
ATOM   817  C CB  . TRP A 1 117 ? 7.487   -31.785 -6.511  1.000 30.230 0 121  TRP A CB  1 ? 
ATOM   818  C CG  . TRP A 1 117 ? 7.507   -33.239 -6.137  1.000 28.322 0 121  TRP A CG  1 ? 
ATOM   819  C CD1 . TRP A 1 117 ? 6.683   -33.870 -5.249  1.000 33.064 0 121  TRP A CD1 1 ? 
ATOM   820  C CD2 . TRP A 1 117 ? 8.418   -34.238 -6.618  1.000 30.617 0 121  TRP A CD2 1 ? 
ATOM   821  N NE1 . TRP A 1 117 ? 7.018   -35.199 -5.152  1.000 33.112 0 121  TRP A NE1 1 ? 
ATOM   822  C CE2 . TRP A 1 117 ? 8.078   -35.452 -5.984  1.000 31.917 0 121  TRP A CE2 1 ? 
ATOM   823  C CE3 . TRP A 1 117 ? 9.482   -34.225 -7.528  1.000 33.070 0 121  TRP A CE3 1 ? 
ATOM   824  C CZ2 . TRP A 1 117 ? 8.764   -36.642 -6.231  1.000 33.217 0 121  TRP A CZ2 1 ? 
ATOM   825  C CZ3 . TRP A 1 117 ? 10.166  -35.409 -7.769  1.000 31.393 0 121  TRP A CZ3 1 ? 
ATOM   826  C CH2 . TRP A 1 117 ? 9.801   -36.600 -7.124  1.000 31.270 0 121  TRP A CH2 1 ? 
ATOM   827  N N   . TRP A 1 118 ? 8.182   -28.637 -5.884  1.000 32.630 0 122  TRP A N   1 ? 
ATOM   828  C CA  . TRP A 1 118 ? 8.439   -27.256 -6.280  1.000 32.504 0 122  TRP A CA  1 ? 
ATOM   829  C C   . TRP A 1 118 ? 9.917   -26.917 -6.145  1.000 31.746 0 122  TRP A C   1 ? 
ATOM   830  O O   . TRP A 1 118 ? 10.501  -26.304 -7.044  1.000 34.033 0 122  TRP A O   1 ? 
ATOM   831  C CB  . TRP A 1 118 ? 7.589   -26.297 -5.442  1.000 32.507 0 122  TRP A CB  1 ? 
ATOM   832  C CG  . TRP A 1 118 ? 7.820   -24.838 -5.748  1.000 33.844 0 122  TRP A CG  1 ? 
ATOM   833  C CD1 . TRP A 1 118 ? 7.182   -24.087 -6.693  1.000 34.870 0 122  TRP A CD1 1 ? 
ATOM   834  C CD2 . TRP A 1 118 ? 8.751   -23.957 -5.098  1.000 38.315 0 122  TRP A CD2 1 ? 
ATOM   835  N NE1 . TRP A 1 118 ? 7.659   -22.796 -6.675  1.000 37.778 0 122  TRP A NE1 1 ? 
ATOM   836  C CE2 . TRP A 1 118 ? 8.622   -22.691 -5.705  1.000 35.873 0 122  TRP A CE2 1 ? 
ATOM   837  C CE3 . TRP A 1 118 ? 9.683   -24.119 -4.065  1.000 39.607 0 122  TRP A CE3 1 ? 
ATOM   838  C CZ2 . TRP A 1 118 ? 9.390   -21.592 -5.313  1.000 35.654 0 122  TRP A CZ2 1 ? 
ATOM   839  C CZ3 . TRP A 1 118 ? 10.444  -23.027 -3.677  1.000 37.549 0 122  TRP A CZ3 1 ? 
ATOM   840  C CH2 . TRP A 1 118 ? 10.294  -21.781 -4.300  1.000 35.191 0 122  TRP A CH2 1 ? 
ATOM   841  N N   . CYS A 1 119 ? 10.546  -27.330 -5.035  1.000 29.240 0 123  CYS A N   1 ? 
ATOM   842  C CA  . CYS A 1 119 ? 11.971  -27.058 -4.844  1.000 31.527 0 123  CYS A CA  1 ? 
ATOM   843  C C   . CYS A 1 119 ? 12.820  -27.707 -5.933  1.000 33.878 0 123  CYS A C   1 ? 
ATOM   844  O O   . CYS A 1 119 ? 13.736  -27.072 -6.472  1.000 32.843 0 123  CYS A O   1 ? 
ATOM   845  C CB  . CYS A 1 119 ? 12.427  -27.535 -3.463  1.000 27.890 0 123  CYS A CB  1 ? 
ATOM   846  S SG  . CYS A 1 119 ? 11.861  -26.487 -2.098  1.000 31.706 0 123  CYS A SG  1 ? 
ATOM   847  N N   . VAL A 1 120 ? 12.547  -28.976 -6.260  1.000 30.375 0 124  VAL A N   1 ? 
ATOM   848  C CA  . VAL A 1 120 ? 13.267  -29.627 -7.356  1.000 32.025 0 124  VAL A CA  1 ? 
ATOM   849  C C   . VAL A 1 120 ? 13.106  -28.820 -8.636  1.000 33.917 0 124  VAL A C   1 ? 
ATOM   850  O O   . VAL A 1 120 ? 14.076  -28.561 -9.360  1.000 33.328 0 124  VAL A O   1 ? 
ATOM   851  C CB  . VAL A 1 120 ? 12.778  -31.074 -7.552  1.000 28.738 0 124  VAL A CB  1 ? 
ATOM   852  C CG1 . VAL A 1 120 ? 13.447  -31.688 -8.792  1.000 29.551 0 124  VAL A CG1 1 ? 
ATOM   853  C CG2 . VAL A 1 120 ? 13.063  -31.915 -6.321  1.000 28.001 0 124  VAL A CG2 1 ? 
ATOM   854  N N   . GLU A 1 121 ? 11.872  -28.398 -8.925  1.000 29.664 0 125  GLU A N   1 ? 
ATOM   855  C CA  . GLU A 1 121 ? 11.611  -27.667 -10.159 1.000 32.899 0 125  GLU A CA  1 ? 
ATOM   856  C C   . GLU A 1 121 ? 12.414  -26.374 -10.227 1.000 35.865 0 125  GLU A C   1 ? 
ATOM   857  O O   . GLU A 1 121 ? 12.860  -25.975 -11.310 1.000 34.931 0 125  GLU A O   1 ? 
ATOM   858  C CB  . GLU A 1 121 ? 10.116  -27.373 -10.288 1.000 37.112 0 125  GLU A CB  1 ? 
ATOM   859  C CG  . GLU A 1 121 ? 9.278   -28.597 -10.644 1.000 43.660 0 125  GLU A CG  1 ? 
ATOM   860  C CD  . GLU A 1 121 ? 9.369   -28.976 -12.114 1.000 50.556 0 125  GLU A CD  1 ? 
ATOM   861  O OE1 . GLU A 1 121 ? 8.893   -30.074 -12.472 1.000 50.806 0 125  GLU A OE1 1 ? 
ATOM   862  O OE2 . GLU A 1 121 ? 9.907   -28.179 -12.914 1.000 53.762 0 125  GLU A OE2 1 ? 
ATOM   863  N N   . GLN A 1 122 ? 12.616  -25.704 -9.084  1.000 33.651 0 126  GLN A N   1 ? 
ATOM   864  C CA  . GLN A 1 122 ? 13.352  -24.440 -9.089  1.000 34.330 0 126  GLN A CA  1 ? 
ATOM   865  C C   . GLN A 1 122 ? 14.795  -24.631 -9.522  1.000 32.825 0 126  GLN A C   1 ? 
ATOM   866  O O   . GLN A 1 122 ? 15.448  -23.671 -9.949  1.000 35.449 0 126  GLN A O   1 ? 
ATOM   867  C CB  . GLN A 1 122 ? 13.325  -23.788 -7.701  1.000 32.462 0 126  GLN A CB  1 ? 
ATOM   868  C CG  . GLN A 1 122 ? 11.940  -23.455 -7.157  1.000 31.862 0 126  GLN A CG  1 ? 
ATOM   869  C CD  . GLN A 1 122 ? 10.969  -23.008 -8.229  1.000 41.831 0 126  GLN A CD  1 ? 
ATOM   870  O OE1 . GLN A 1 122 ? 10.004  -23.711 -8.543  1.000 45.661 0 126  GLN A OE1 1 ? 
ATOM   871  N NE2 . GLN A 1 122 ? 11.215  -21.831 -8.798  1.000 38.810 0 126  GLN A NE2 1 ? 
ATOM   872  N N   . THR A 1 123 ? 15.304  -25.850 -9.411  1.000 30.977 0 127  THR A N   1 ? 
ATOM   873  C CA  . THR A 1 123 ? 16.673  -26.156 -9.773  1.000 28.040 0 127  THR A CA  1 ? 
ATOM   874  C C   . THR A 1 123 ? 16.879  -26.204 -11.283 1.000 31.654 0 127  THR A C   1 ? 
ATOM   875  O O   . THR A 1 123 ? 18.021  -26.114 -11.752 1.000 32.330 0 127  THR A O   1 ? 
ATOM   876  C CB  . THR A 1 123 ? 17.042  -27.492 -9.118  1.000 34.473 0 127  THR A CB  1 ? 
ATOM   877  O OG1 . THR A 1 123 ? 16.803  -27.399 -7.708  1.000 46.479 0 127  THR A OG1 1 ? 
ATOM   878  C CG2 . THR A 1 123 ? 18.435  -27.753 -9.274  1.000 49.714 0 127  THR A CG2 1 ? 
ATOM   879  N N   . LEU A 1 124 ? 15.800  -26.311 -12.055 1.000 32.322 0 128  LEU A N   1 ? 
ATOM   880  C CA  . LEU A 1 124 ? 15.903  -26.560 -13.486 1.000 32.491 0 128  LEU A CA  1 ? 
ATOM   881  C C   . LEU A 1 124 ? 15.869  -25.292 -14.323 1.000 36.789 0 128  LEU A C   1 ? 
ATOM   882  O O   . LEU A 1 124 ? 16.139  -25.355 -15.529 1.000 35.588 0 128  LEU A O   1 ? 
ATOM   883  C CB  . LEU A 1 124 ? 14.777  -27.500 -13.930 1.000 30.975 0 128  LEU A CB  1 ? 
ATOM   884  C CG  . LEU A 1 124 ? 14.814  -28.848 -13.210 1.000 34.107 0 128  LEU A CG  1 ? 
ATOM   885  C CD1 . LEU A 1 124 ? 13.695  -29.742 -13.727 1.000 39.331 0 128  LEU A CD1 1 ? 
ATOM   886  C CD2 . LEU A 1 124 ? 16.172  -29.498 -13.400 1.000 33.322 0 128  LEU A CD2 1 ? 
ATOM   887  N N   . SER A 1 125 ? 15.545  -24.153 -13.725 1.000 35.125 0 129  SER A N   1 ? 
ATOM   888  C CA  . SER A 1 125 ? 15.558  -22.899 -14.463 1.000 41.613 0 129  SER A CA  1 ? 
ATOM   889  C C   . SER A 1 125 ? 15.877  -21.774 -13.494 1.000 43.421 0 129  SER A C   1 ? 
ATOM   890  O O   . SER A 1 125 ? 15.287  -21.698 -12.412 1.000 45.982 0 129  SER A O   1 ? 
ATOM   891  C CB  . SER A 1 125 ? 14.218  -22.650 -15.162 1.000 48.956 0 129  SER A CB  1 ? 
ATOM   892  O OG  . SER A 1 125 ? 13.374  -21.849 -14.359 1.000 56.523 0 129  SER A OG  1 ? 
ATOM   893  N N   . GLY A 1 126 ? 16.815  -20.917 -13.883 1.000 42.395 0 130  GLY A N   1 ? 
ATOM   894  C CA  . GLY A 1 126 ? 17.175  -19.772 -13.088 1.000 41.779 0 130  GLY A CA  1 ? 
ATOM   895  C C   . GLY A 1 126 ? 16.995  -18.478 -13.854 1.000 47.311 0 130  GLY A C   1 ? 
ATOM   896  O O   . GLY A 1 126 ? 16.567  -18.464 -15.015 1.000 45.621 0 130  GLY A O   1 ? 
ATOM   897  N N   . PRO A 1 127 ? 17.313  -17.360 -13.206 1.000 44.595 0 131  PRO A N   1 ? 
ATOM   898  C CA  . PRO A 1 127 ? 17.214  -16.064 -13.885 1.000 45.319 0 131  PRO A CA  1 ? 
ATOM   899  C C   . PRO A 1 127 ? 18.122  -16.010 -15.104 1.000 48.345 0 131  PRO A C   1 ? 
ATOM   900  O O   . PRO A 1 127 ? 19.151  -16.687 -15.170 1.000 49.482 0 131  PRO A O   1 ? 
ATOM   901  C CB  . PRO A 1 127 ? 17.659  -15.066 -12.810 1.000 47.672 0 131  PRO A CB  1 ? 
ATOM   902  C CG  . PRO A 1 127 ? 17.456  -15.782 -11.508 1.000 48.553 0 131  PRO A CG  1 ? 
ATOM   903  C CD  . PRO A 1 127 ? 17.725  -17.224 -11.799 1.000 44.713 0 131  PRO A CD  1 ? 
ATOM   904  N N   . ASN A 1 128 ? 17.715  -15.199 -16.087 1.000 53.375 0 132  ASN A N   1 ? 
ATOM   905  C CA  . ASN A 1 128 ? 18.515  -14.954 -17.289 1.000 55.720 0 132  ASN A CA  1 ? 
ATOM   906  C C   . ASN A 1 128 ? 18.716  -16.230 -18.107 1.000 52.396 0 132  ASN A C   1 ? 
ATOM   907  O O   . ASN A 1 128 ? 19.787  -16.465 -18.672 1.000 52.964 0 132  ASN A O   1 ? 
ATOM   908  C CB  . ASN A 1 128 ? 19.863  -14.320 -16.928 1.000 67.074 0 132  ASN A CB  1 ? 
ATOM   909  C CG  . ASN A 1 128 ? 20.387  -13.401 -18.014 1.000 79.004 0 132  ASN A CG  1 ? 
ATOM   910  O OD1 . ASN A 1 128 ? 19.651  -13.005 -18.919 1.000 84.558 0 132  ASN A OD1 1 ? 
ATOM   911  N ND2 . ASN A 1 128 ? 21.668  -13.059 -17.931 1.000 82.120 0 132  ASN A ND2 1 ? 
ATOM   912  N N   . GLY A 1 129 ? 17.681  -17.065 -18.177 1.000 48.861 0 133  GLY A N   1 ? 
ATOM   913  C CA  . GLY A 1 129 ? 17.746  -18.249 -19.016 1.000 47.450 0 133  GLY A CA  1 ? 
ATOM   914  C C   . GLY A 1 129 ? 18.689  -19.331 -18.541 1.000 46.432 0 133  GLY A C   1 ? 
ATOM   915  O O   . GLY A 1 129 ? 19.135  -20.152 -19.347 1.000 43.568 0 133  GLY A O   1 ? 
ATOM   916  N N   . TRP A 1 130 ? 19.006  -19.356 -17.250 1.000 43.542 0 134  TRP A N   1 ? 
ATOM   917  C CA  . TRP A 1 130 ? 19.878  -20.388 -16.703 1.000 39.349 0 134  TRP A CA  1 ? 
ATOM   918  C C   . TRP A 1 130 ? 19.191  -21.746 -16.766 1.000 36.691 0 134  TRP A C   1 ? 
ATOM   919  O O   . TRP A 1 130 ? 18.067  -21.907 -16.279 1.000 39.244 0 134  TRP A O   1 ? 
ATOM   920  C CB  . TRP A 1 130 ? 20.236  -20.043 -15.257 1.000 38.870 0 134  TRP A CB  1 ? 
ATOM   921  C CG  . TRP A 1 130 ? 21.440  -20.760 -14.663 1.000 38.378 0 134  TRP A CG  1 ? 
ATOM   922  C CD1 . TRP A 1 130 ? 22.701  -20.254 -14.524 1.000 37.099 0 134  TRP A CD1 1 ? 
ATOM   923  C CD2 . TRP A 1 130 ? 21.473  -22.077 -14.084 1.000 37.328 0 134  TRP A CD2 1 ? 
ATOM   924  N NE1 . TRP A 1 130 ? 23.522  -21.177 -13.918 1.000 35.465 0 134  TRP A NE1 1 ? 
ATOM   925  C CE2 . TRP A 1 130 ? 22.794  -22.304 -13.638 1.000 35.973 0 134  TRP A CE2 1 ? 
ATOM   926  C CE3 . TRP A 1 130 ? 20.524  -23.092 -13.919 1.000 37.018 0 134  TRP A CE3 1 ? 
ATOM   927  C CZ2 . TRP A 1 130 ? 23.184  -23.498 -13.025 1.000 35.046 0 134  TRP A CZ2 1 ? 
ATOM   928  C CZ3 . TRP A 1 130 ? 20.914  -24.281 -13.315 1.000 34.983 0 134  TRP A CZ3 1 ? 
ATOM   929  C CH2 . TRP A 1 130 ? 22.234  -24.474 -12.878 1.000 36.970 0 134  TRP A CH2 1 ? 
ATOM   930  N N   . THR A 1 131 ? 19.866  -22.722 -17.366 1.000 38.239 0 135  THR A N   1 ? 
ATOM   931  C CA  . THR A 1 131 ? 19.442  -24.113 -17.338 1.000 36.591 0 135  THR A CA  1 ? 
ATOM   932  C C   . THR A 1 131 ? 20.644  -24.988 -17.024 1.000 32.391 0 135  THR A C   1 ? 
ATOM   933  O O   . THR A 1 131 ? 21.774  -24.645 -17.386 1.000 36.583 0 135  THR A O   1 ? 
ATOM   934  C CB  . THR A 1 131 ? 18.823  -24.557 -18.676 1.000 39.247 0 135  THR A CB  1 ? 
ATOM   935  O OG1 . THR A 1 131 ? 19.757  -24.334 -19.740 1.000 38.599 0 135  THR A OG1 1 ? 
ATOM   936  C CG2 . THR A 1 131 ? 17.530  -23.797 -18.960 1.000 39.197 0 135  THR A CG2 1 ? 
ATOM   937  N N   . PRO A 1 132 ? 20.439  -26.121 -16.354 1.000 30.343 0 136  PRO A N   1 ? 
ATOM   938  C CA  . PRO A 1 132 ? 21.575  -26.991 -16.042 1.000 31.772 0 136  PRO A CA  1 ? 
ATOM   939  C C   . PRO A 1 132 ? 22.084  -27.714 -17.279 1.000 30.822 0 136  PRO A C   1 ? 
ATOM   940  O O   . PRO A 1 132 ? 21.349  -27.949 -18.244 1.000 33.246 0 136  PRO A O   1 ? 
ATOM   941  C CB  . PRO A 1 132 ? 21.001  -27.978 -15.014 1.000 31.091 0 136  PRO A CB  1 ? 
ATOM   942  C CG  . PRO A 1 132 ? 19.535  -28.040 -15.326 1.000 30.630 0 136  PRO A CG  1 ? 
ATOM   943  C CD  . PRO A 1 132 ? 19.156  -26.673 -15.872 1.000 33.970 0 136  PRO A CD  1 ? 
ATOM   944  N N   . ASN A 1 133 ? 23.379  -28.041 -17.257 1.000 30.680 0 137  ASN A N   1 ? 
ATOM   945  C CA  . ASN A 1 133 ? 23.937  -29.009 -18.193 1.000 29.651 0 137  ASN A CA  1 ? 
ATOM   946  C C   . ASN A 1 133 ? 24.459  -30.244 -17.468 1.000 29.546 0 137  ASN A C   1 ? 
ATOM   947  O O   . ASN A 1 133 ? 25.044  -31.132 -18.105 1.000 31.001 0 137  ASN A O   1 ? 
ATOM   948  C CB  . ASN A 1 133 ? 25.024  -28.369 -19.076 1.000 31.301 0 137  ASN A CB  1 ? 
ATOM   949  C CG  . ASN A 1 133 ? 26.179  -27.754 -18.279 1.000 32.299 0 137  ASN A CG  1 ? 
ATOM   950  O OD1 . ASN A 1 133 ? 26.351  -28.006 -17.087 1.000 29.746 0 137  ASN A OD1 1 ? 
ATOM   951  N ND2 . ASN A 1 133 ? 26.991  -26.947 -18.960 1.000 32.588 0 137  ASN A ND2 1 ? 
ATOM   952  N N   . LEU A 1 134 ? 24.228  -30.336 -16.157 1.000 28.796 0 138  LEU A N   1 ? 
ATOM   953  C CA  . LEU A 1 134 ? 24.645  -31.469 -15.343 1.000 26.053 0 138  LEU A CA  1 ? 
ATOM   954  C C   . LEU A 1 134 ? 23.612  -31.682 -14.247 1.000 25.577 0 138  LEU A C   1 ? 
ATOM   955  O O   . LEU A 1 134 ? 23.017  -30.721 -13.750 1.000 26.403 0 138  LEU A O   1 ? 
ATOM   956  C CB  . LEU A 1 134 ? 26.027  -31.232 -14.716 1.000 27.237 0 138  LEU A CB  1 ? 
ATOM   957  C CG  . LEU A 1 134 ? 27.238  -31.292 -15.649 1.000 28.935 0 138  LEU A CG  1 ? 
ATOM   958  C CD1 . LEU A 1 134 ? 28.410  -30.521 -15.040 1.000 28.869 0 138  LEU A CD1 1 ? 
ATOM   959  C CD2 . LEU A 1 134 ? 27.626  -32.747 -15.918 1.000 28.617 0 138  LEU A CD2 1 ? 
ATOM   960  N N   . LEU A 1 135 ? 23.396  -32.947 -13.879 1.000 24.916 0 139  LEU A N   1 ? 
ATOM   961  C CA  . LEU A 1 135 ? 22.537  -33.298 -12.753 1.000 25.664 0 139  LEU A CA  1 ? 
ATOM   962  C C   . LEU A 1 135 ? 23.348  -34.045 -11.705 1.000 24.690 0 139  LEU A C   1 ? 
ATOM   963  O O   . LEU A 1 135 ? 24.181  -34.898 -12.036 1.000 24.053 0 139  LEU A O   1 ? 
ATOM   964  C CB  . LEU A 1 135 ? 21.340  -34.170 -13.177 1.000 23.150 0 139  LEU A CB  1 ? 
ATOM   965  C CG  . LEU A 1 135 ? 20.464  -33.668 -14.326 1.000 24.474 0 139  LEU A CG  1 ? 
ATOM   966  C CD1 . LEU A 1 135 ? 19.370  -34.696 -14.620 1.000 26.685 0 139  LEU A CD1 1 ? 
ATOM   967  C CD2 . LEU A 1 135 ? 19.846  -32.323 -13.995 1.000 25.614 0 139  LEU A CD2 1 ? 
ATOM   968  N N   . LEU A 1 136 ? 23.092  -33.720 -10.439 1.000 24.029 0 140  LEU A N   1 ? 
ATOM   969  C CA  . LEU A 1 136 ? 23.676  -34.422 -9.302  1.000 23.008 0 140  LEU A CA  1 ? 
ATOM   970  C C   . LEU A 1 136 ? 22.509  -34.868 -8.432  1.000 23.192 0 140  LEU A C   1 ? 
ATOM   971  O O   . LEU A 1 136 ? 21.786  -34.032 -7.882  1.000 24.977 0 140  LEU A O   1 ? 
ATOM   972  C CB  . LEU A 1 136 ? 24.652  -33.522 -8.537  1.000 21.603 0 140  LEU A CB  1 ? 
ATOM   973  C CG  . LEU A 1 136 ? 25.610  -34.210 -7.558  1.000 23.374 0 140  LEU A CG  1 ? 
ATOM   974  C CD1 . LEU A 1 136 ? 26.869  -33.364 -7.341  1.000 26.485 0 140  LEU A CD1 1 ? 
ATOM   975  C CD2 . LEU A 1 136 ? 24.925  -34.478 -6.217  1.000 22.587 0 140  LEU A CD2 1 ? 
ATOM   976  N N   . ASP A 1 137 ? 22.301  -36.176 -8.326  1.000 20.579 0 141  ASP A N   1 ? 
ATOM   977  C CA  . ASP A 1 137 ? 21.050  -36.701 -7.799  1.000 21.008 0 141  ASP A CA  1 ? 
ATOM   978  C C   . ASP A 1 137 ? 21.335  -37.693 -6.685  1.000 20.395 0 141  ASP A C   1 ? 
ATOM   979  O O   . ASP A 1 137 ? 22.385  -38.342 -6.662  1.000 22.761 0 141  ASP A O   1 ? 
ATOM   980  C CB  . ASP A 1 137 ? 20.232  -37.381 -8.907  1.000 24.582 0 141  ASP A CB  1 ? 
ATOM   981  C CG  . ASP A 1 137 ? 18.738  -37.410 -8.614  1.000 28.045 0 141  ASP A CG  1 ? 
ATOM   982  O OD1 . ASP A 1 137 ? 18.292  -36.899 -7.564  1.000 26.730 0 141  ASP A OD1 1 ? 
ATOM   983  O OD2 . ASP A 1 137 ? 18.008  -37.958 -9.459  1.000 26.908 0 141  ASP A OD2 1 ? 
ATOM   984  N N   . ASP A 1 138 ? 20.377  -37.802 -5.764  1.000 21.421 0 142  ASP A N   1 ? 
ATOM   985  C CA  . ASP A 1 138 ? 20.455  -38.718 -4.623  1.000 20.079 0 142  ASP A CA  1 ? 
ATOM   986  C C   . ASP A 1 138 ? 19.054  -39.309 -4.479  1.000 23.808 0 142  ASP A C   1 ? 
ATOM   987  O O   . ASP A 1 138 ? 18.175  -38.719 -3.849  1.000 23.419 0 142  ASP A O   1 ? 
ATOM   988  C CB  . ASP A 1 138 ? 20.933  -37.978 -3.373  1.000 21.208 0 142  ASP A CB  1 ? 
ATOM   989  C CG  . ASP A 1 138 ? 21.042  -38.860 -2.151  1.000 23.774 0 142  ASP A CG  1 ? 
ATOM   990  O OD1 . ASP A 1 138 ? 20.492  -39.988 -2.139  1.000 22.637 0 142  ASP A OD1 1 ? 
ATOM   991  O OD2 . ASP A 1 138 ? 21.680  -38.406 -1.174  1.000 23.474 0 142  ASP A OD2 1 ? 
ATOM   992  N N   . GLY A 1 139 ? 18.839  -40.462 -5.111  1.000 19.973 0 143  GLY A N   1 ? 
ATOM   993  C CA  . GLY A 1 139 ? 17.572  -41.158 -5.032  1.000 20.792 0 143  GLY A CA  1 ? 
ATOM   994  C C   . GLY A 1 139 ? 16.798  -41.233 -6.327  1.000 24.306 0 143  GLY A C   1 ? 
ATOM   995  O O   . GLY A 1 139 ? 15.818  -41.992 -6.391  1.000 23.358 0 143  GLY A O   1 ? 
ATOM   996  N N   . GLY A 1 140 ? 17.167  -40.451 -7.345  1.000 22.763 0 144  GLY A N   1 ? 
ATOM   997  C CA  . GLY A 1 140 ? 16.541  -40.533 -8.653  1.000 21.708 0 144  GLY A CA  1 ? 
ATOM   998  C C   . GLY A 1 140 ? 15.371  -39.594 -8.901  1.000 23.608 0 144  GLY A C   1 ? 
ATOM   999  O O   . GLY A 1 140 ? 14.825  -39.604 -10.015 1.000 25.374 0 144  GLY A O   1 ? 
ATOM   1000 N N   . ASP A 1 141 ? 14.971  -38.778 -7.917  1.000 24.037 0 145  ASP A N   1 ? 
ATOM   1001 C CA  . ASP A 1 141 ? 13.815  -37.903 -8.125  1.000 25.256 0 145  ASP A CA  1 ? 
ATOM   1002 C C   . ASP A 1 141 ? 14.112  -36.815 -9.151  1.000 29.777 0 145  ASP A C   1 ? 
ATOM   1003 O O   . ASP A 1 141 ? 13.274  -36.523 -10.011 1.000 28.148 0 145  ASP A O   1 ? 
ATOM   1004 C CB  . ASP A 1 141 ? 13.373  -37.271 -6.806  1.000 24.811 0 145  ASP A CB  1 ? 
ATOM   1005 C CG  . ASP A 1 141 ? 12.626  -38.239 -5.912  1.000 26.961 0 145  ASP A CG  1 ? 
ATOM   1006 O OD1 . ASP A 1 141 ? 12.231  -39.327 -6.393  1.000 25.735 0 145  ASP A OD1 1 ? 
ATOM   1007 O OD2 . ASP A 1 141 ? 12.429  -37.893 -4.726  1.000 27.482 0 145  ASP A OD2 1 ? 
ATOM   1008 N N   . LEU A 1 142 ? 15.286  -36.184 -9.067  1.000 25.285 0 146  LEU A N   1 ? 
ATOM   1009 C CA  . LEU A 1 142 ? 15.632  -35.166 -10.057 1.000 25.524 0 146  LEU A CA  1 ? 
ATOM   1010 C C   . LEU A 1 142 ? 15.747  -35.778 -11.448 1.000 25.832 0 146  LEU A C   1 ? 
ATOM   1011 O O   . LEU A 1 142 ? 15.267  -35.204 -12.436 1.000 27.269 0 146  LEU A O   1 ? 
ATOM   1012 C CB  . LEU A 1 142 ? 16.936  -34.472 -9.652  1.000 24.432 0 146  LEU A CB  1 ? 
ATOM   1013 C CG  . LEU A 1 142 ? 17.576  -33.519 -10.662 1.000 26.098 0 146  LEU A CG  1 ? 
ATOM   1014 C CD1 . LEU A 1 142 ? 16.649  -32.364 -10.986 1.000 28.643 0 146  LEU A CD1 1 ? 
ATOM   1015 C CD2 . LEU A 1 142 ? 18.913  -33.023 -10.117 1.000 27.856 0 146  LEU A CD2 1 ? 
ATOM   1016 N N   . THR A 1 143 ? 16.389  -36.944 -11.540 1.000 24.727 0 147  THR A N   1 ? 
ATOM   1017 C CA  . THR A 1 143 ? 16.478  -37.664 -12.805 1.000 23.961 0 147  THR A CA  1 ? 
ATOM   1018 C C   . THR A 1 143 ? 15.089  -37.965 -13.361 1.000 28.732 0 147  THR A C   1 ? 
ATOM   1019 O O   . THR A 1 143 ? 14.860  -37.857 -14.572 1.000 27.793 0 147  THR A O   1 ? 
ATOM   1020 C CB  . THR A 1 143 ? 17.288  -38.946 -12.588 1.000 26.119 0 147  THR A CB  1 ? 
ATOM   1021 O OG1 . THR A 1 143 ? 18.598  -38.592 -12.116 1.000 26.343 0 147  THR A OG1 1 ? 
ATOM   1022 C CG2 . THR A 1 143 ? 17.434  -39.753 -13.866 1.000 24.740 0 147  THR A CG2 1 ? 
ATOM   1023 N N   . GLN A 1 144 ? 14.148  -38.330 -12.484 1.000 25.669 0 148  GLN A N   1 ? 
ATOM   1024 C CA  . GLN A 1 144 ? 12.781  -38.616 -12.923 1.000 25.593 0 148  GLN A CA  1 ? 
ATOM   1025 C C   . GLN A 1 144 ? 12.112  -37.366 -13.477 1.000 30.206 0 148  GLN A C   1 ? 
ATOM   1026 O O   . GLN A 1 144 ? 11.540  -37.388 -14.578 1.000 29.946 0 148  GLN A O   1 ? 
ATOM   1027 C CB  . GLN A 1 144 ? 11.957  -39.184 -11.762 1.000 26.390 0 148  GLN A CB  1 ? 
ATOM   1028 C CG  . GLN A 1 144 ? 10.484  -39.418 -12.134 1.000 27.527 0 148  GLN A CG  1 ? 
ATOM   1029 C CD  . GLN A 1 144 ? 9.598   -39.734 -10.940 1.000 27.803 0 148  GLN A CD  1 ? 
ATOM   1030 O OE1 . GLN A 1 144 ? 10.039  -39.703 -9.790  1.000 29.172 0 148  GLN A OE1 1 ? 
ATOM   1031 N NE2 . GLN A 1 144 ? 8.321   -40.023 -11.212 1.000 29.206 0 148  GLN A NE2 1 ? 
ATOM   1032 N N   . VAL A 1 145 ? 12.168  -36.266 -12.720 1.000 30.201 0 149  VAL A N   1 ? 
ATOM   1033 C CA  . VAL A 1 145 ? 11.510  -35.026 -13.134 1.000 28.490 0 149  VAL A CA  1 ? 
ATOM   1034 C C   . VAL A 1 145 ? 11.994  -34.597 -14.513 1.000 28.346 0 149  VAL A C   1 ? 
ATOM   1035 O O   . VAL A 1 145 ? 11.197  -34.206 -15.377 1.000 30.227 0 149  VAL A O   1 ? 
ATOM   1036 C CB  . VAL A 1 145 ? 11.748  -33.919 -12.091 1.000 30.977 0 149  VAL A CB  1 ? 
ATOM   1037 C CG1 . VAL A 1 145 ? 11.387  -32.559 -12.670 1.000 36.857 0 149  VAL A CG1 1 ? 
ATOM   1038 C CG2 . VAL A 1 145 ? 10.926  -34.182 -10.865 1.000 36.041 0 149  VAL A CG2 1 ? 
ATOM   1039 N N   . VAL A 1 146 ? 13.309  -34.653 -14.742 1.000 27.603 0 150  VAL A N   1 ? 
ATOM   1040 C CA  . VAL A 1 146 ? 13.839  -34.184 -16.018 1.000 28.693 0 150  VAL A CA  1 ? 
ATOM   1041 C C   . VAL A 1 146 ? 13.392  -35.103 -17.151 1.000 31.783 0 150  VAL A C   1 ? 
ATOM   1042 O O   . VAL A 1 146 ? 12.932  -34.636 -18.200 1.000 33.949 0 150  VAL A O   1 ? 
ATOM   1043 C CB  . VAL A 1 146 ? 15.373  -34.055 -15.958 1.000 27.248 0 150  VAL A CB  1 ? 
ATOM   1044 C CG1 . VAL A 1 146 ? 15.926  -33.659 -17.321 1.000 29.227 0 150  VAL A CG1 1 ? 
ATOM   1045 C CG2 . VAL A 1 146 ? 15.774  -33.025 -14.906 1.000 30.530 0 150  VAL A CG2 1 ? 
ATOM   1046 N N   . HIS A 1 147 ? 13.511  -36.424 -16.956 1.000 29.833 0 151  HIS A N   1 ? 
ATOM   1047 C CA  . HIS A 1 147 ? 13.138  -37.358 -18.018 1.000 29.893 0 151  HIS A CA  1 ? 
ATOM   1048 C C   . HIS A 1 147 ? 11.640  -37.322 -18.304 1.000 29.556 0 151  HIS A C   1 ? 
ATOM   1049 O O   . HIS A 1 147 ? 11.225  -37.393 -19.467 1.000 34.304 0 151  HIS A O   1 ? 
ATOM   1050 C CB  . HIS A 1 147 ? 13.544  -38.783 -17.650 1.000 32.075 0 151  HIS A CB  1 ? 
ATOM   1051 C CG  . HIS A 1 147 ? 14.978  -39.098 -17.926 1.000 29.627 0 151  HIS A CG  1 ? 
ATOM   1052 N ND1 . HIS A 1 147 ? 15.980  -38.810 -17.028 1.000 27.853 0 151  HIS A ND1 1 ? 
ATOM   1053 C CD2 . HIS A 1 147 ? 15.579  -39.691 -18.985 1.000 28.227 0 151  HIS A CD2 1 ? 
ATOM   1054 C CE1 . HIS A 1 147 ? 17.140  -39.208 -17.524 1.000 29.764 0 151  HIS A CE1 1 ? 
ATOM   1055 N NE2 . HIS A 1 147 ? 16.924  -39.749 -18.710 1.000 30.009 0 151  HIS A NE2 1 ? 
ATOM   1056 N N   . GLN A 1 148 ? 10.813  -37.238 -17.263 1.000 33.659 0 152  GLN A N   1 ? 
ATOM   1057 C CA  . GLN A 1 148 ? 9.374   -37.404 -17.440 1.000 31.441 0 152  GLN A CA  1 ? 
ATOM   1058 C C   . GLN A 1 148 ? 8.635   -36.091 -17.679 1.000 39.228 0 152  GLN A C   1 ? 
ATOM   1059 O O   . GLN A 1 148 ? 7.570   -36.104 -18.310 1.000 43.447 0 152  GLN A O   1 ? 
ATOM   1060 C CB  . GLN A 1 148 ? 8.776   -38.123 -16.221 1.000 35.062 0 152  GLN A CB  1 ? 
ATOM   1061 C CG  . GLN A 1 148 ? 9.256   -39.570 -16.068 1.000 29.564 0 152  GLN A CG  1 ? 
ATOM   1062 C CD  . GLN A 1 148 ? 8.633   -40.286 -14.891 1.000 28.677 0 152  GLN A CD  1 ? 
ATOM   1063 O OE1 . GLN A 1 148 ? 7.805   -39.724 -14.171 1.000 31.404 0 152  GLN A OE1 1 ? 
ATOM   1064 N NE2 . GLN A 1 148 ? 9.041   -41.537 -14.674 1.000 29.717 0 152  GLN A NE2 1 ? 
ATOM   1065 N N   . LYS A 1 149 ? 9.177   -34.960 -17.218 1.000 36.275 0 153  LYS A N   1 ? 
ATOM   1066 C CA  . LYS A 1 149 ? 8.488   -33.680 -17.323 1.000 36.033 0 153  LYS A CA  1 ? 
ATOM   1067 C C   . LYS A 1 149 ? 9.207   -32.635 -18.167 1.000 38.010 0 153  LYS A C   1 ? 
ATOM   1068 O O   . LYS A 1 149 ? 8.552   -31.683 -18.614 1.000 38.960 0 153  LYS A O   1 ? 
ATOM   1069 C CB  . LYS A 1 149 ? 8.238   -33.091 -15.924 1.000 38.523 0 153  LYS A CB  1 ? 
ATOM   1070 C CG  . LYS A 1 149 ? 7.433   -33.995 -15.004 1.000 49.201 0 153  LYS A CG  1 ? 
ATOM   1071 C CD  . LYS A 1 149 ? 5.960   -33.643 -15.020 1.000 60.541 0 153  LYS A CD  1 ? 
ATOM   1072 C CE  . LYS A 1 149 ? 5.246   -34.199 -13.795 1.000 69.127 0 153  LYS A CE  1 ? 
ATOM   1073 N NZ  . LYS A 1 149 ? 5.314   -33.275 -12.627 1.000 72.582 0 153  LYS A NZ  1 ? 
ATOM   1074 N N   . HIS A 1 150 ? 10.511  -32.779 -18.415 1.000 37.676 0 154  HIS A N   1 ? 
ATOM   1075 C CA  . HIS A 1 150 ? 11.288  -31.768 -19.143 1.000 40.684 0 154  HIS A CA  1 ? 
ATOM   1076 C C   . HIS A 1 150 ? 12.196  -32.419 -20.182 1.000 40.413 0 154  HIS A C   1 ? 
ATOM   1077 O O   . HIS A 1 150 ? 13.415  -32.217 -20.175 1.000 37.304 0 154  HIS A O   1 ? 
ATOM   1078 C CB  . HIS A 1 150 ? 12.112  -30.922 -18.173 1.000 37.947 0 154  HIS A CB  1 ? 
ATOM   1079 C CG  . HIS A 1 150 ? 11.300  -30.265 -17.101 1.000 40.513 0 154  HIS A CG  1 ? 
ATOM   1080 N ND1 . HIS A 1 150 ? 10.606  -29.093 -17.307 1.000 45.855 0 154  HIS A ND1 1 ? 
ATOM   1081 C CD2 . HIS A 1 150 ? 11.068  -30.619 -15.815 1.000 41.397 0 154  HIS A CD2 1 ? 
ATOM   1082 C CE1 . HIS A 1 150 ? 9.984   -28.750 -16.193 1.000 45.474 0 154  HIS A CE1 1 ? 
ATOM   1083 N NE2 . HIS A 1 150 ? 10.251  -29.658 -15.271 1.000 42.242 0 154  HIS A NE2 1 ? 
ATOM   1084 N N   . PRO A 1 151 ? 11.627  -33.179 -21.125 1.000 47.187 0 155  PRO A N   1 ? 
ATOM   1085 C CA  . PRO A 1 151 ? 12.479  -33.852 -22.121 1.000 49.061 0 155  PRO A CA  1 ? 
ATOM   1086 C C   . PRO A 1 151 ? 13.300  -32.894 -22.971 1.000 50.019 0 155  PRO A C   1 ? 
ATOM   1087 O O   . PRO A 1 151 ? 14.340  -33.299 -23.505 1.000 47.745 0 155  PRO A O   1 ? 
ATOM   1088 C CB  . PRO A 1 151 ? 11.470  -34.634 -22.972 1.000 52.722 0 155  PRO A CB  1 ? 
ATOM   1089 C CG  . PRO A 1 151 ? 10.199  -33.862 -22.835 1.000 51.530 0 155  PRO A CG  1 ? 
ATOM   1090 C CD  . PRO A 1 151 ? 10.194  -33.368 -21.418 1.000 46.037 0 155  PRO A CD  1 ? 
ATOM   1091 N N   . LYS A 1 152 ? 12.872  -31.637 -23.109 1.000 44.700 0 156  LYS A N   1 ? 
ATOM   1092 C CA  . LYS A 1 152 ? 13.659  -30.656 -23.848 1.000 48.422 0 156  LYS A CA  1 ? 
ATOM   1093 C C   . LYS A 1 152 ? 14.977  -30.343 -23.147 1.000 45.426 0 156  LYS A C   1 ? 
ATOM   1094 O O   . LYS A 1 152 ? 15.975  -30.047 -23.811 1.000 42.021 0 156  LYS A O   1 ? 
ATOM   1095 C CB  . LYS A 1 152 ? 12.840  -29.377 -24.050 1.000 56.141 0 156  LYS A CB  1 ? 
ATOM   1096 C CG  . LYS A 1 152 ? 12.485  -28.637 -22.758 1.000 60.265 0 156  LYS A CG  1 ? 
ATOM   1097 C CD  . LYS A 1 152 ? 11.223  -29.179 -22.097 1.000 51.777 0 156  LYS A CD  1 ? 
ATOM   1098 C CE  . LYS A 1 152 ? 10.930  -28.415 -20.837 1.000 47.356 0 156  LYS A CE  1 ? 
ATOM   1099 N NZ  . LYS A 1 152 ? 9.664   -28.860 -20.214 1.000 49.906 0 156  LYS A NZ  1 ? 
ATOM   1100 N N   . LEU A 1 153 ? 15.002  -30.407 -21.813 1.000 48.401 0 157  LEU A N   1 ? 
ATOM   1101 C CA  . LEU A 1 153 ? 16.235  -30.160 -21.072 1.000 43.989 0 157  LEU A CA  1 ? 
ATOM   1102 C C   . LEU A 1 153 ? 17.257  -31.267 -21.290 1.000 37.073 0 157  LEU A C   1 ? 
ATOM   1103 O O   . LEU A 1 153 ? 18.465  -31.010 -21.224 1.000 35.878 0 157  LEU A O   1 ? 
ATOM   1104 C CB  . LEU A 1 153 ? 15.931  -30.029 -19.581 1.000 49.445 0 157  LEU A CB  1 ? 
ATOM   1105 C CG  . LEU A 1 153 ? 15.858  -28.631 -18.979 1.000 59.631 0 157  LEU A CG  1 ? 
ATOM   1106 C CD1 . LEU A 1 153 ? 15.414  -28.724 -17.528 1.000 56.359 0 157  LEU A CD1 1 ? 
ATOM   1107 C CD2 . LEU A 1 153 ? 17.213  -27.945 -19.090 1.000 61.976 0 157  LEU A CD2 1 ? 
ATOM   1108 N N   . LEU A 1 154 ? 16.789  -32.495 -21.544 1.000 42.950 0 158  LEU A N   1 ? 
ATOM   1109 C CA  . LEU A 1 154 ? 17.676  -33.654 -21.634 1.000 41.589 0 158  LEU A CA  1 ? 
ATOM   1110 C C   . LEU A 1 154 ? 18.786  -33.447 -22.655 1.000 47.508 0 158  LEU A C   1 ? 
ATOM   1111 O O   . LEU A 1 154 ? 19.929  -33.861 -22.428 1.000 46.092 0 158  LEU A O   1 ? 
ATOM   1112 C CB  . LEU A 1 154 ? 16.872  -34.903 -21.995 1.000 43.495 0 158  LEU A CB  1 ? 
ATOM   1113 C CG  . LEU A 1 154 ? 16.123  -35.654 -20.897 1.000 38.444 0 158  LEU A CG  1 ? 
ATOM   1114 C CD1 . LEU A 1 154 ? 15.252  -36.749 -21.500 1.000 39.421 0 158  LEU A CD1 1 ? 
ATOM   1115 C CD2 . LEU A 1 154 ? 17.087  -36.244 -19.871 1.000 33.512 0 158  LEU A CD2 1 ? 
ATOM   1116 N N   . THR A 1 155 ? 18.466  -32.828 -23.797 1.000 44.995 0 159  THR A N   1 ? 
ATOM   1117 C CA  . THR A 1 155 ? 19.460  -32.665 -24.854 1.000 43.832 0 159  THR A CA  1 ? 
ATOM   1118 C C   . THR A 1 155 ? 20.687  -31.925 -24.353 1.000 42.221 0 159  THR A C   1 ? 
ATOM   1119 O O   . THR A 1 155 ? 21.817  -32.238 -24.747 1.000 47.490 0 159  THR A O   1 ? 
ATOM   1120 C CB  . THR A 1 155 ? 18.851  -31.915 -26.038 1.000 50.032 0 159  THR A CB  1 ? 
ATOM   1121 O OG1 . THR A 1 155 ? 17.539  -32.422 -26.301 1.000 53.741 0 159  THR A OG1 1 ? 
ATOM   1122 C CG2 . THR A 1 155 ? 19.725  -32.082 -27.270 1.000 53.859 0 159  THR A CG2 1 ? 
ATOM   1123 N N   . ALA A 1 156 ? 20.488  -30.943 -23.481 1.000 40.844 0 160  ALA A N   1 ? 
ATOM   1124 C CA  . ALA A 1 156 ? 21.586  -30.139 -22.971 1.000 43.729 0 160  ALA A CA  1 ? 
ATOM   1125 C C   . ALA A 1 156 ? 22.250  -30.731 -21.733 1.000 35.059 0 160  ALA A C   1 ? 
ATOM   1126 O O   . ALA A 1 156 ? 23.262  -30.182 -21.285 1.000 38.244 0 160  ALA A O   1 ? 
ATOM   1127 C CB  . ALA A 1 156 ? 21.093  -28.721 -22.656 1.000 46.369 0 160  ALA A CB  1 ? 
ATOM   1128 N N   . ILE A 1 157 ? 21.719  -31.818 -21.171 1.000 38.236 0 161  ILE A N   1 ? 
ATOM   1129 C CA  . ILE A 1 157 ? 22.290  -32.426 -19.968 1.000 30.988 0 161  ILE A CA  1 ? 
ATOM   1130 C C   . ILE A 1 157 ? 23.398  -33.385 -20.379 1.000 32.238 0 161  ILE A C   1 ? 
ATOM   1131 O O   . ILE A 1 157 ? 23.148  -34.373 -21.081 1.000 32.372 0 161  ILE A O   1 ? 
ATOM   1132 C CB  . ILE A 1 157 ? 21.228  -33.161 -19.137 1.000 30.738 0 161  ILE A CB  1 ? 
ATOM   1133 C CG1 . ILE A 1 157 ? 20.122  -32.209 -18.671 1.000 38.876 0 161  ILE A CG1 1 ? 
ATOM   1134 C CG2 . ILE A 1 157 ? 21.896  -33.873 -17.937 1.000 29.604 0 161  ILE A CG2 1 ? 
ATOM   1135 C CD1 . ILE A 1 157 ? 20.588  -31.177 -17.692 1.000 41.084 0 161  ILE A CD1 1 ? 
ATOM   1136 N N   . LYS A 1 158 ? 24.619  -33.111 -19.916 1.000 27.906 0 162  LYS A N   1 ? 
ATOM   1137 C CA  . LYS A 1 158 ? 25.750  -33.973 -20.240 1.000 28.714 0 162  LYS A CA  1 ? 
ATOM   1138 C C   . LYS A 1 158 ? 25.681  -35.309 -19.507 1.000 30.891 0 162  LYS A C   1 ? 
ATOM   1139 O O   . LYS A 1 158 ? 26.160  -36.323 -20.028 1.000 30.725 0 162  LYS A O   1 ? 
ATOM   1140 C CB  . LYS A 1 158 ? 27.059  -33.251 -19.921 1.000 29.809 0 162  LYS A CB  1 ? 
ATOM   1141 C CG  . LYS A 1 158 ? 27.242  -31.939 -20.695 1.000 29.904 0 162  LYS A CG  1 ? 
ATOM   1142 C CD  . LYS A 1 158 ? 28.359  -31.095 -20.094 1.000 29.901 0 162  LYS A CD  1 ? 
ATOM   1143 C CE  . LYS A 1 158 ? 28.757  -29.941 -21.022 1.000 35.899 0 162  LYS A CE  1 ? 
ATOM   1144 N NZ  . LYS A 1 158 ? 29.234  -30.406 -22.361 1.000 37.044 0 162  LYS A NZ  1 ? 
ATOM   1145 N N   . GLY A 1 159 ? 25.107  -35.333 -18.310 1.000 25.561 0 163  GLY A N   1 ? 
ATOM   1146 C CA  . GLY A 1 159 ? 24.985  -36.575 -17.574 1.000 25.935 0 163  GLY A CA  1 ? 
ATOM   1147 C C   . GLY A 1 159 ? 24.521  -36.312 -16.158 1.000 24.532 0 163  GLY A C   1 ? 
ATOM   1148 O O   . GLY A 1 159 ? 24.347  -35.163 -15.735 1.000 28.198 0 163  GLY A O   1 ? 
ATOM   1149 N N   . VAL A 1 160 ? 24.294  -37.410 -15.439 1.000 24.374 0 164  VAL A N   1 ? 
ATOM   1150 C CA  . VAL A 1 160 ? 23.903  -37.369 -14.034 1.000 24.811 0 164  VAL A CA  1 ? 
ATOM   1151 C C   . VAL A 1 160 ? 24.877  -38.228 -13.238 1.000 25.358 0 164  VAL A C   1 ? 
ATOM   1152 O O   . VAL A 1 160 ? 25.303  -39.294 -13.702 1.000 24.053 0 164  VAL A O   1 ? 
ATOM   1153 C CB  . VAL A 1 160 ? 22.444  -37.850 -13.825 1.000 24.782 0 164  VAL A CB  1 ? 
ATOM   1154 C CG1 . VAL A 1 160 ? 22.239  -39.246 -14.417 1.000 26.616 0 164  VAL A CG1 1 ? 
ATOM   1155 C CG2 . VAL A 1 160 ? 22.068  -37.825 -12.351 1.000 25.064 0 164  VAL A CG2 1 ? 
ATOM   1156 N N   . SER A 1 161 ? 25.247  -37.761 -12.047 1.000 22.100 0 165  SER A N   1 ? 
ATOM   1157 C CA  . SER A 1 161 ? 25.950  -38.596 -11.080 1.000 19.371 0 165  SER A CA  1 ? 
ATOM   1158 C C   . SER A 1 161 ? 25.004  -38.892 -9.919  1.000 24.663 0 165  SER A C   1 ? 
ATOM   1159 O O   . SER A 1 161 ? 24.387  -37.975 -9.365  1.000 25.208 0 165  SER A O   1 ? 
ATOM   1160 C CB  . SER A 1 161 ? 27.248  -37.933 -10.591 1.000 24.013 0 165  SER A CB  1 ? 
ATOM   1161 O OG  . SER A 1 161 ? 27.019  -36.634 -10.066 1.000 25.129 0 165  SER A OG  1 ? 
ATOM   1162 N N   . GLU A 1 162 ? 24.875  -40.173 -9.570  1.000 20.992 0 166  GLU A N   1 ? 
ATOM   1163 C CA  . GLU A 1 162 ? 23.842  -40.637 -8.648  1.000 20.087 0 166  GLU A CA  1 ? 
ATOM   1164 C C   . GLU A 1 162 ? 24.464  -41.200 -7.376  1.000 20.087 0 166  GLU A C   1 ? 
ATOM   1165 O O   . GLU A 1 162 ? 25.333  -42.078 -7.436  1.000 21.666 0 166  GLU A O   1 ? 
ATOM   1166 C CB  . GLU A 1 162 ? 22.948  -41.688 -9.321  1.000 21.779 0 166  GLU A CB  1 ? 
ATOM   1167 C CG  . GLU A 1 162 ? 21.993  -42.435 -8.375  1.000 21.995 0 166  GLU A CG  1 ? 
ATOM   1168 C CD  . GLU A 1 162 ? 21.039  -41.526 -7.614  1.000 20.847 0 166  GLU A CD  1 ? 
ATOM   1169 O OE1 . GLU A 1 162 ? 20.987  -41.656 -6.374  1.000 21.155 0 166  GLU A OE1 1 ? 
ATOM   1170 O OE2 . GLU A 1 162 ? 20.335  -40.691 -8.237  1.000 23.821 0 166  GLU A OE2 1 ? 
ATOM   1171 N N   . GLU A 1 163 ? 23.955  -40.732 -6.229  1.000 20.521 0 167  GLU A N   1 ? 
ATOM   1172 C CA  . GLU A 1 163 ? 24.565  -40.951 -4.919  1.000 19.960 0 167  GLU A CA  1 ? 
ATOM   1173 C C   . GLU A 1 163 ? 24.224  -42.304 -4.297  1.000 20.679 0 167  GLU A C   1 ? 
ATOM   1174 O O   . GLU A 1 163 ? 25.065  -42.872 -3.598  1.000 21.131 0 167  GLU A O   1 ? 
ATOM   1175 C CB  . GLU A 1 163 ? 24.129  -39.830 -3.957  1.000 21.221 0 167  GLU A CB  1 ? 
ATOM   1176 C CG  . GLU A 1 163 ? 24.719  -39.904 -2.522  1.000 20.239 0 167  GLU A CG  1 ? 
ATOM   1177 C CD  . GLU A 1 163 ? 26.168  -39.448 -2.436  1.000 28.080 0 167  GLU A CD  1 ? 
ATOM   1178 O OE1 . GLU A 1 163 ? 26.725  -39.432 -1.316  1.000 25.890 0 167  GLU A OE1 1 ? 
ATOM   1179 O OE2 . GLU A 1 163 ? 26.757  -39.118 -3.482  1.000 27.006 0 167  GLU A OE2 1 ? 
ATOM   1180 N N   . THR A 1 164 ? 23.000  -42.818 -4.464  1.000 21.187 0 168  THR A N   1 ? 
ATOM   1181 C CA  . THR A 1 164 ? 22.543  -43.860 -3.545  1.000 22.142 0 168  THR A CA  1 ? 
ATOM   1182 C C   . THR A 1 164 ? 21.980  -45.082 -4.263  1.000 20.595 0 168  THR A C   1 ? 
ATOM   1183 O O   . THR A 1 164 ? 21.596  -45.039 -5.433  1.000 21.510 0 168  THR A O   1 ? 
ATOM   1184 C CB  . THR A 1 164 ? 21.502  -43.305 -2.544  1.000 20.526 0 168  THR A CB  1 ? 
ATOM   1185 O OG1 . THR A 1 164 ? 21.405  -44.194 -1.412  1.000 20.163 0 168  THR A OG1 1 ? 
ATOM   1186 C CG2 . THR A 1 164 ? 20.124  -43.121 -3.200  1.000 20.542 0 168  THR A CG2 1 ? 
ATOM   1187 N N   . THR A 1 165 ? 21.955  -46.190 -3.512  1.000 19.700 0 169  THR A N   1 ? 
ATOM   1188 C CA  . THR A 1 165 ? 21.592  -47.491 -4.061  1.000 18.036 0 169  THR A CA  1 ? 
ATOM   1189 C C   . THR A 1 165 ? 20.240  -47.455 -4.773  1.000 20.971 0 169  THR A C   1 ? 
ATOM   1190 O O   . THR A 1 165 ? 20.108  -47.953 -5.895  1.000 21.203 0 169  THR A O   1 ? 
ATOM   1191 C CB  . THR A 1 165 ? 21.593  -48.523 -2.932  1.000 20.481 0 169  THR A CB  1 ? 
ATOM   1192 O OG1 . THR A 1 165 ? 22.626  -48.181 -1.994  1.000 21.108 0 169  THR A OG1 1 ? 
ATOM   1193 C CG2 . THR A 1 165 ? 21.839  -49.921 -3.472  1.000 22.650 0 169  THR A CG2 1 ? 
ATOM   1194 N N   . THR A 1 166 ? 19.228  -46.841 -4.145  1.000 19.573 0 170  THR A N   1 ? 
ATOM   1195 C CA  . THR A 1 166 ? 17.894  -46.779 -4.752  1.000 20.066 0 170  THR A CA  1 ? 
ATOM   1196 C C   . THR A 1 166 ? 17.901  -45.987 -6.055  1.000 20.916 0 170  THR A C   1 ? 
ATOM   1197 O O   . THR A 1 166 ? 17.231  -46.364 -7.027  1.000 22.355 0 170  THR A O   1 ? 
ATOM   1198 C CB  . THR A 1 166 ? 16.906  -46.163 -3.762  1.000 21.563 0 170  THR A CB  1 ? 
ATOM   1199 O OG1 . THR A 1 166 ? 16.564  -47.139 -2.778  1.000 22.253 0 170  THR A OG1 1 ? 
ATOM   1200 C CG2 . THR A 1 166 ? 15.632  -45.681 -4.469  1.000 23.163 0 170  THR A CG2 1 ? 
ATOM   1201 N N   . GLY A 1 167 ? 18.653  -44.886 -6.097  1.000 19.618 0 171  GLY A N   1 ? 
ATOM   1202 C CA  . GLY A 1 167 ? 18.751  -44.131 -7.336  1.000 21.853 0 171  GLY A CA  1 ? 
ATOM   1203 C C   . GLY A 1 167 ? 19.373  -44.940 -8.456  1.000 21.992 0 171  GLY A C   1 ? 
ATOM   1204 O O   . GLY A 1 167 ? 18.927  -44.871 -9.606  1.000 24.308 0 171  GLY A O   1 ? 
ATOM   1205 N N   . VAL A 1 168 ? 20.391  -45.738 -8.130  1.000 21.192 0 172  VAL A N   1 ? 
ATOM   1206 C CA  . VAL A 1 168 ? 21.044  -46.571 -9.137  1.000 20.671 0 172  VAL A CA  1 ? 
ATOM   1207 C C   . VAL A 1 168 ? 20.096  -47.663 -9.610  1.000 20.447 0 172  VAL A C   1 ? 
ATOM   1208 O O   . VAL A 1 168 ? 20.027  -47.967 -10.806 1.000 24.795 0 172  VAL A O   1 ? 
ATOM   1209 C CB  . VAL A 1 168 ? 22.356  -47.150 -8.577  1.000 23.045 0 172  VAL A CB  1 ? 
ATOM   1210 C CG1 . VAL A 1 168 ? 23.007  -48.082 -9.593  1.000 26.395 0 172  VAL A CG1 1 ? 
ATOM   1211 C CG2 . VAL A 1 168 ? 23.311  -46.018 -8.215  1.000 23.145 0 172  VAL A CG2 1 ? 
ATOM   1212 N N   . ALA A 1 169 ? 19.341  -48.258 -8.684  1.000 22.463 0 173  ALA A N   1 ? 
ATOM   1213 C CA  . ALA A 1 169 ? 18.344  -49.247 -9.079  1.000 22.482 0 173  ALA A CA  1 ? 
ATOM   1214 C C   . ALA A 1 169 ? 17.369  -48.654 -10.082 1.000 26.145 0 173  ALA A C   1 ? 
ATOM   1215 O O   . ALA A 1 169 ? 17.037  -49.286 -11.092 1.000 25.042 0 173  ALA A O   1 ? 
ATOM   1216 C CB  . ALA A 1 169 ? 17.597  -49.772 -7.852  1.000 24.964 0 173  ALA A CB  1 ? 
ATOM   1217 N N   . ARG A 1 170 ? 16.929  -47.417 -9.836  1.000 24.995 0 174  ARG A N   1 ? 
ATOM   1218 C CA  . ARG A 1 170 ? 16.035  -46.750 -10.773 1.000 24.800 0 174  ARG A CA  1 ? 
ATOM   1219 C C   . ARG A 1 170 ? 16.711  -46.507 -12.121 1.000 24.900 0 174  ARG A C   1 ? 
ATOM   1220 O O   . ARG A 1 170 ? 16.064  -46.624 -13.166 1.000 27.769 0 174  ARG A O   1 ? 
ATOM   1221 C CB  . ARG A 1 170 ? 15.529  -45.439 -10.170 1.000 26.140 0 174  ARG A CB  1 ? 
ATOM   1222 C CG  . ARG A 1 170 ? 14.626  -45.631 -8.943  1.000 25.719 0 174  ARG A CG  1 ? 
ATOM   1223 C CD  . ARG A 1 170 ? 14.289  -44.285 -8.313  1.000 24.271 0 174  ARG A CD  1 ? 
ATOM   1224 N NE  . ARG A 1 170 ? 13.227  -43.602 -9.046  1.000 22.734 0 174  ARG A NE  1 ? 
ATOM   1225 C CZ  . ARG A 1 170 ? 12.752  -42.399 -8.730  1.000 25.882 0 174  ARG A CZ  1 ? 
ATOM   1226 N NH1 . ARG A 1 170 ? 13.262  -41.732 -7.699  1.000 25.679 0 174  ARG A NH1 1 ? 
ATOM   1227 N NH2 . ARG A 1 170 ? 11.751  -41.873 -9.436  1.000 25.169 0 174  ARG A NH2 1 ? 
ATOM   1228 N N   . LEU A 1 171 ? 18.021  -46.194 -12.125 1.000 24.374 0 175  LEU A N   1 ? 
ATOM   1229 C CA  . LEU A 1 171 ? 18.726  -46.000 -13.394 1.000 22.266 0 175  LEU A CA  1 ? 
ATOM   1230 C C   . LEU A 1 171 ? 18.834  -47.307 -14.176 1.000 24.290 0 175  LEU A C   1 ? 
ATOM   1231 O O   . LEU A 1 171 ? 18.660  -47.319 -15.401 1.000 26.553 0 175  LEU A O   1 ? 
ATOM   1232 C CB  . LEU A 1 171 ? 20.137  -45.433 -13.152 1.000 23.011 0 175  LEU A CB  1 ? 
ATOM   1233 C CG  . LEU A 1 171 ? 20.267  -43.979 -12.692 1.000 25.435 0 175  LEU A CG  1 ? 
ATOM   1234 C CD1 . LEU A 1 171 ? 21.697  -43.700 -12.213 1.000 27.056 0 175  LEU A CD1 1 ? 
ATOM   1235 C CD2 . LEU A 1 171 ? 19.874  -43.037 -13.820 1.000 25.653 0 175  LEU A CD2 1 ? 
ATOM   1236 N N   . TYR A 1 172 ? 19.156  -48.406 -13.485 1.000 27.061 0 176  TYR A N   1 ? 
ATOM   1237 C CA  . TYR A 1 172 ? 19.239  -49.708 -14.140 1.000 27.206 0 176  TYR A CA  1 ? 
ATOM   1238 C C   . TYR A 1 172 ? 17.930  -50.051 -14.833 1.000 29.875 0 176  TYR A C   1 ? 
ATOM   1239 O O   . TYR A 1 172 ? 17.923  -50.534 -15.973 1.000 28.714 0 176  TYR A O   1 ? 
ATOM   1240 C CB  . TYR A 1 172 ? 19.567  -50.803 -13.122 1.000 23.674 0 176  TYR A CB  1 ? 
ATOM   1241 C CG  . TYR A 1 172 ? 20.969  -50.839 -12.536 1.000 34.162 0 176  TYR A CG  1 ? 
ATOM   1242 C CD1 . TYR A 1 172 ? 22.055  -50.315 -13.212 1.000 29.551 0 176  TYR A CD1 1 ? 
ATOM   1243 C CD2 . TYR A 1 172 ? 21.190  -51.433 -11.294 1.000 39.052 0 176  TYR A CD2 1 ? 
ATOM   1244 C CE1 . TYR A 1 172 ? 23.346  -50.374 -12.658 1.000 32.635 0 176  TYR A CE1 1 ? 
ATOM   1245 C CE2 . TYR A 1 172 ? 22.455  -51.498 -10.735 1.000 43.684 0 176  TYR A CE2 1 ? 
ATOM   1246 C CZ  . TYR A 1 172 ? 23.531  -50.969 -11.416 1.000 43.342 0 176  TYR A CZ  1 ? 
ATOM   1247 O OH  . TYR A 1 172 ? 24.782  -51.050 -10.826 1.000 42.989 0 176  TYR A OH  1 ? 
ATOM   1248 N N   . GLU A 1 173 ? 16.805  -49.820 -14.150 1.000 27.835 0 177  GLU A N   1 ? 
ATOM   1249 C CA  . GLU A 1 173 ? 15.520  -50.156 -14.749 1.000 28.172 0 177  GLU A CA  1 ? 
ATOM   1250 C C   . GLU A 1 173 ? 15.207  -49.233 -15.922 1.000 28.382 0 177  GLU A C   1 ? 
ATOM   1251 O O   . GLU A 1 173 ? 14.664  -49.679 -16.941 1.000 29.235 0 177  GLU A O   1 ? 
ATOM   1252 C CB  . GLU A 1 173 ? 14.424  -50.113 -13.686 1.000 33.512 0 177  GLU A CB  1 ? 
ATOM   1253 C CG  . GLU A 1 173 ? 14.316  -51.420 -12.890 1.000 47.835 0 177  GLU A CG  1 ? 
ATOM   1254 C CD  . GLU A 1 173 ? 13.878  -52.609 -13.752 1.000 55.822 0 177  GLU A CD  1 ? 
ATOM   1255 O OE1 . GLU A 1 173 ? 12.741  -52.590 -14.265 1.000 57.823 0 177  GLU A OE1 1 ? 
ATOM   1256 O OE2 . GLU A 1 173 ? 14.670  -53.563 -13.917 1.000 56.446 0 177  GLU A OE2 1 ? 
ATOM   1257 N N   . MET A 1 174 ? 15.567  -47.949 -15.818 1.000 25.693 0 178  MET A N   1 ? 
ATOM   1258 C CA  . MET A 1 174 ? 15.400  -47.067 -16.972 1.000 27.135 0 178  MET A CA  1 ? 
ATOM   1259 C C   . MET A 1 174 ? 16.218  -47.563 -18.157 1.000 26.332 0 178  MET A C   1 ? 
ATOM   1260 O O   . MET A 1 174 ? 15.706  -47.667 -19.277 1.000 29.546 0 178  MET A O   1 ? 
ATOM   1261 C CB  . MET A 1 174 ? 15.798  -45.635 -16.621 1.000 30.885 0 178  MET A CB  1 ? 
ATOM   1262 C CG  . MET A 1 174 ? 14.833  -44.942 -15.669 1.000 35.112 0 178  MET A CG  1 ? 
ATOM   1263 S SD  . MET A 1 174 ? 15.509  -43.372 -15.078 1.000 34.349 0 178  MET A SD  1 ? 
ATOM   1264 C CE  . MET A 1 174 ? 15.337  -42.430 -16.591 1.000 26.622 0 178  MET A CE  1 ? 
ATOM   1265 N N   . ALA A 1 175 ? 17.492  -47.891 -17.920 1.000 25.906 0 179  ALA A N   1 ? 
ATOM   1266 C CA  . ALA A 1 175 ? 18.359  -48.339 -19.009 1.000 25.714 0 179  ALA A CA  1 ? 
ATOM   1267 C C   . ALA A 1 175 ? 17.834  -49.619 -19.650 1.000 28.880 0 179  ALA A C   1 ? 
ATOM   1268 O O   . ALA A 1 175 ? 17.817  -49.745 -20.882 1.000 31.499 0 179  ALA A O   1 ? 
ATOM   1269 C CB  . ALA A 1 175 ? 19.786  -48.541 -18.492 1.000 27.095 0 179  ALA A CB  1 ? 
ATOM   1270 N N   . LYS A 1 176 ? 17.389  -50.576 -18.829 1.000 30.380 0 180  LYS A N   1 ? 
ATOM   1271 C CA  . LYS A 1 176 ? 16.851  -51.827 -19.353 1.000 29.833 0 180  LYS A CA  1 ? 
ATOM   1272 C C   . LYS A 1 176 ? 15.677  -51.588 -20.297 1.000 36.683 0 180  LYS A C   1 ? 
ATOM   1273 O O   . LYS A 1 176 ? 15.494  -52.336 -21.266 1.000 35.865 0 180  LYS A O   1 ? 
ATOM   1274 C CB  . LYS A 1 176 ? 16.426  -52.726 -18.189 1.000 36.954 0 180  LYS A CB  1 ? 
ATOM   1275 C CG  . LYS A 1 176 ? 15.632  -53.960 -18.580 1.000 45.337 0 180  LYS A CG  1 ? 
ATOM   1276 C CD  . LYS A 1 176 ? 15.480  -54.905 -17.390 1.000 54.283 0 180  LYS A CD  1 ? 
ATOM   1277 C CE  . LYS A 1 176 ? 14.075  -55.492 -17.308 1.000 61.157 0 180  LYS A CE  1 ? 
ATOM   1278 N NZ  . LYS A 1 176 ? 13.661  -55.744 -15.893 1.000 63.050 0 180  LYS A NZ  1 ? 
ATOM   1279 N N   . HIS A 1 177 ? 14.877  -50.555 -20.043 1.000 34.904 0 181  HIS A N   1 ? 
ATOM   1280 C CA  . HIS A 1 177 ? 13.689  -50.290 -20.842 1.000 32.112 0 181  HIS A CA  1 ? 
ATOM   1281 C C   . HIS A 1 177 ? 13.890  -49.176 -21.852 1.000 34.554 0 181  HIS A C   1 ? 
ATOM   1282 O O   . HIS A 1 177 ? 12.909  -48.700 -22.432 1.000 36.565 0 181  HIS A O   1 ? 
ATOM   1283 C CB  . HIS A 1 177 ? 12.509  -49.960 -19.931 1.000 34.123 0 181  HIS A CB  1 ? 
ATOM   1284 C CG  . HIS A 1 177 ? 12.040  -51.125 -19.124 1.000 33.865 0 181  HIS A CG  1 ? 
ATOM   1285 N ND1 . HIS A 1 177 ? 12.403  -51.314 -17.809 1.000 35.828 0 181  HIS A ND1 1 ? 
ATOM   1286 C CD2 . HIS A 1 177 ? 11.254  -52.176 -19.455 1.000 35.088 0 181  HIS A CD2 1 ? 
ATOM   1287 C CE1 . HIS A 1 177 ? 11.847  -52.424 -17.357 1.000 39.123 0 181  HIS A CE1 1 ? 
ATOM   1288 N NE2 . HIS A 1 177 ? 11.149  -52.968 -18.336 1.000 37.062 0 181  HIS A NE2 1 ? 
ATOM   1289 N N   . GLY A 1 178 ? 15.132  -48.753 -22.080 1.000 36.744 0 182  GLY A N   1 ? 
ATOM   1290 C CA  . GLY A 1 178 ? 15.403  -47.703 -23.043 1.000 34.938 0 182  GLY A CA  1 ? 
ATOM   1291 C C   . GLY A 1 178 ? 14.931  -46.324 -22.636 1.000 36.681 0 182  GLY A C   1 ? 
ATOM   1292 O O   . GLY A 1 178 ? 14.746  -45.466 -23.504 1.000 39.326 0 182  GLY A O   1 ? 
ATOM   1293 N N   . GLN A 1 179 ? 14.727  -46.086 -21.337 1.000 34.049 0 183  GLN A N   1 ? 
ATOM   1294 C CA  . GLN A 1 179 ? 14.247  -44.798 -20.847 1.000 32.459 0 183  GLN A CA  1 ? 
ATOM   1295 C C   . GLN A 1 179 ? 15.369  -43.844 -20.458 1.000 31.317 0 183  GLN A C   1 ? 
ATOM   1296 O O   . GLN A 1 179 ? 15.106  -42.653 -20.264 1.000 32.375 0 183  GLN A O   1 ? 
ATOM   1297 C CB  . GLN A 1 179 ? 13.339  -44.983 -19.621 1.000 31.588 0 183  GLN A CB  1 ? 
ATOM   1298 C CG  . GLN A 1 179 ? 12.146  -45.911 -19.812 1.000 35.057 0 183  GLN A CG  1 ? 
ATOM   1299 C CD  . GLN A 1 179 ? 11.439  -46.217 -18.493 1.000 35.504 0 183  GLN A CD  1 ? 
ATOM   1300 O OE1 . GLN A 1 179 ? 11.920  -47.015 -17.687 1.000 34.296 0 183  GLN A OE1 1 ? 
ATOM   1301 N NE2 . GLN A 1 179 ? 10.290  -45.586 -18.275 1.000 36.657 0 183  GLN A NE2 1 ? 
ATOM   1302 N N   . LEU A 1 180 ? 16.594  -44.338 -20.303 1.000 29.011 0 184  LEU A N   1 ? 
ATOM   1303 C CA  . LEU A 1 180 ? 17.711  -43.500 -19.879 1.000 26.780 0 184  LEU A CA  1 ? 
ATOM   1304 C C   . LEU A 1 180 ? 18.266  -42.753 -21.086 1.000 28.880 0 184  LEU A C   1 ? 
ATOM   1305 O O   . LEU A 1 180 ? 18.723  -43.380 -22.048 1.000 33.717 0 184  LEU A O   1 ? 
ATOM   1306 C CB  . LEU A 1 180 ? 18.793  -44.360 -19.234 1.000 26.624 0 184  LEU A CB  1 ? 
ATOM   1307 C CG  . LEU A 1 180 ? 20.029  -43.593 -18.776 1.000 28.448 0 184  LEU A CG  1 ? 
ATOM   1308 C CD1 . LEU A 1 180 ? 19.643  -42.513 -17.781 1.000 28.485 0 184  LEU A CD1 1 ? 
ATOM   1309 C CD2 . LEU A 1 180 ? 21.023  -44.561 -18.164 1.000 26.982 0 184  LEU A CD2 1 ? 
ATOM   1310 N N   . LYS A 1 181 ? 18.210  -41.420 -21.055 1.000 27.788 0 185  LYS A N   1 ? 
ATOM   1311 C CA  . LYS A 1 181 ? 18.563  -40.609 -22.216 1.000 30.641 0 185  LYS A CA  1 ? 
ATOM   1312 C C   . LYS A 1 181 ? 19.822  -39.778 -21.997 1.000 31.696 0 185  LYS A C   1 ? 
ATOM   1313 O O   . LYS A 1 181 ? 20.126  -38.906 -22.820 1.000 32.209 0 185  LYS A O   1 ? 
ATOM   1314 C CB  . LYS A 1 181 ? 17.394  -39.697 -22.603 1.000 29.838 0 185  LYS A CB  1 ? 
ATOM   1315 C CG  . LYS A 1 181 ? 16.047  -40.411 -22.733 1.000 32.596 0 185  LYS A CG  1 ? 
ATOM   1316 C CD  . LYS A 1 181 ? 16.022  -41.352 -23.925 1.000 38.070 0 185  LYS A CD  1 ? 
ATOM   1317 C CE  . LYS A 1 181 ? 14.676  -42.069 -24.013 1.000 41.452 0 185  LYS A CE  1 ? 
ATOM   1318 N NZ  . LYS A 1 181 ? 14.650  -43.086 -25.096 1.000 42.845 0 185  LYS A NZ  1 ? 
ATOM   1319 N N   . ILE A 1 182 ? 20.551  -40.019 -20.910 1.000 31.775 0 186  ILE A N   1 ? 
ATOM   1320 C CA  . ILE A 1 182 ? 21.823  -39.355 -20.615 1.000 30.033 0 186  ILE A CA  1 ? 
ATOM   1321 C C   . ILE A 1 182 ? 22.769  -40.371 -19.994 1.000 28.851 0 186  ILE A C   1 ? 
ATOM   1322 O O   . ILE A 1 182 ? 22.331  -41.390 -19.441 1.000 29.293 0 186  ILE A O   1 ? 
ATOM   1323 C CB  . ILE A 1 182 ? 21.642  -38.159 -19.651 1.000 29.896 0 186  ILE A CB  1 ? 
ATOM   1324 C CG1 . ILE A 1 182 ? 20.984  -38.622 -18.347 1.000 30.319 0 186  ILE A CG1 1 ? 
ATOM   1325 C CG2 . ILE A 1 182 ? 20.817  -37.058 -20.293 1.000 32.130 0 186  ILE A CG2 1 ? 
ATOM   1326 C CD1 . ILE A 1 182 ? 20.850  -37.531 -17.298 1.000 31.170 0 186  ILE A CD1 1 ? 
ATOM   1327 N N   . PRO A 1 183 ? 24.078  -40.125 -20.070 1.000 28.130 0 187  PRO A N   1 ? 
ATOM   1328 C CA  . PRO A 1 183 ? 25.017  -40.955 -19.304 1.000 25.869 0 187  PRO A CA  1 ? 
ATOM   1329 C C   . PRO A 1 183 ? 24.813  -40.773 -17.807 1.000 25.232 0 187  PRO A C   1 ? 
ATOM   1330 O O   . PRO A 1 183 ? 24.413  -39.708 -17.336 1.000 27.785 0 187  PRO A O   1 ? 
ATOM   1331 C CB  . PRO A 1 183 ? 26.397  -40.444 -19.744 1.000 25.429 0 187  PRO A CB  1 ? 
ATOM   1332 C CG  . PRO A 1 183 ? 26.158  -39.736 -21.063 1.000 27.416 0 187  PRO A CG  1 ? 
ATOM   1333 C CD  . PRO A 1 183 ? 24.768  -39.166 -20.955 1.000 26.666 0 187  PRO A CD  1 ? 
ATOM   1334 N N   . ALA A 1 184 ? 25.086  -41.835 -17.052 1.000 24.156 0 188  ALA A N   1 ? 
ATOM   1335 C CA  . ALA A 1 184 ? 24.968  -41.791 -15.600 1.000 24.011 0 188  ALA A CA  1 ? 
ATOM   1336 C C   . ALA A 1 184 ? 26.223  -42.375 -14.977 1.000 29.130 0 188  ALA A C   1 ? 
ATOM   1337 O O   . ALA A 1 184 ? 26.677  -43.448 -15.389 1.000 25.237 0 188  ALA A O   1 ? 
ATOM   1338 C CB  . ALA A 1 184 ? 23.733  -42.559 -15.108 1.000 26.382 0 188  ALA A CB  1 ? 
ATOM   1339 N N   . ILE A 1 185 ? 26.782  -41.668 -13.994 1.000 23.053 0 189  ILE A N   1 ? 
ATOM   1340 C CA  . ILE A 1 185 ? 27.883  -42.186 -13.187 1.000 21.737 0 189  ILE A CA  1 ? 
ATOM   1341 C C   . ILE A 1 185 ? 27.309  -42.649 -11.861 1.000 23.963 0 189  ILE A C   1 ? 
ATOM   1342 O O   . ILE A 1 185 ? 26.695  -41.864 -11.125 1.000 24.308 0 189  ILE A O   1 ? 
ATOM   1343 C CB  . ILE A 1 185 ? 28.985  -41.142 -12.963 1.000 21.761 0 189  ILE A CB  1 ? 
ATOM   1344 C CG1 . ILE A 1 185 ? 29.546  -40.650 -14.299 1.000 29.914 0 189  ILE A CG1 1 ? 
ATOM   1345 C CG2 . ILE A 1 185 ? 30.086  -41.725 -12.057 1.000 23.692 0 189  ILE A CG2 1 ? 
ATOM   1346 C CD1 . ILE A 1 185 ? 30.250  -41.712 -15.103 1.000 33.107 0 189  ILE A CD1 1 ? 
ATOM   1347 N N   . ASN A 1 186 ? 27.504  -43.926 -11.570 1.000 22.542 0 190  ASN A N   1 ? 
ATOM   1348 C CA  . ASN A 1 186 ? 27.054  -44.541 -10.328 1.000 21.945 0 190  ASN A CA  1 ? 
ATOM   1349 C C   . ASN A 1 186 ? 28.110  -44.243 -9.272  1.000 21.971 0 190  ASN A C   1 ? 
ATOM   1350 O O   . ASN A 1 186 ? 29.152  -44.906 -9.212  1.000 20.884 0 190  ASN A O   1 ? 
ATOM   1351 C CB  . ASN A 1 186 ? 26.846  -46.035 -10.555 1.000 22.921 0 190  ASN A CB  1 ? 
ATOM   1352 C CG  . ASN A 1 186 ? 26.638  -46.807 -9.284  1.000 21.697 0 190  ASN A CG  1 ? 
ATOM   1353 O OD1 . ASN A 1 186 ? 26.576  -46.242 -8.195  1.000 20.671 0 190  ASN A OD1 1 ? 
ATOM   1354 N ND2 . ASN A 1 186 ? 26.523  -48.124 -9.418  1.000 21.426 0 190  ASN A ND2 1 ? 
ATOM   1355 N N   . VAL A 1 187 ? 27.851  -43.217 -8.455  1.000 20.795 0 191  VAL A N   1 ? 
ATOM   1356 C CA  . VAL A 1 187 ? 28.753  -42.870 -7.361  1.000 20.692 0 191  VAL A CA  1 ? 
ATOM   1357 C C   . VAL A 1 187 ? 28.562  -43.809 -6.174  1.000 19.084 0 191  VAL A C   1 ? 
ATOM   1358 O O   . VAL A 1 187 ? 29.517  -44.090 -5.437  1.000 19.944 0 191  VAL A O   1 ? 
ATOM   1359 C CB  . VAL A 1 187 ? 28.534  -41.398 -6.960  1.000 23.098 0 191  VAL A CB  1 ? 
ATOM   1360 C CG1 . VAL A 1 187 ? 29.214  -41.073 -5.633  1.000 23.950 0 191  VAL A CG1 1 ? 
ATOM   1361 C CG2 . VAL A 1 187 ? 29.060  -40.485 -8.051  1.000 24.424 0 191  VAL A CG2 1 ? 
ATOM   1362 N N   . ASN A 1 188 ? 27.342  -44.315 -5.963  1.000 18.397 0 192  ASN A N   1 ? 
ATOM   1363 C CA  . ASN A 1 188 ? 27.131  -45.229 -4.846  1.000 18.465 0 192  ASN A CA  1 ? 
ATOM   1364 C C   . ASN A 1 188 ? 28.149  -46.358 -4.844  1.000 20.858 0 192  ASN A C   1 ? 
ATOM   1365 O O   . ASN A 1 188 ? 28.642  -46.757 -3.785  1.000 19.137 0 192  ASN A O   1 ? 
ATOM   1366 C CB  . ASN A 1 188 ? 25.723  -45.817 -4.885  1.000 19.255 0 192  ASN A CB  1 ? 
ATOM   1367 C CG  . ASN A 1 188 ? 25.450  -46.687 -3.679  1.000 20.858 0 192  ASN A CG  1 ? 
ATOM   1368 O OD1 . ASN A 1 188 ? 25.337  -46.180 -2.561  1.000 19.810 0 192  ASN A OD1 1 ? 
ATOM   1369 N ND2 . ASN A 1 188 ? 25.374  -48.000 -3.887  1.000 20.350 0 192  ASN A ND2 1 ? 
ATOM   1370 N N   . ASN A 1 189 ? 28.486  -46.888 -6.015  1.000 18.721 0 193  ASN A N   1 ? 
ATOM   1371 C CA  . ASN A 1 189 ? 29.330  -48.073 -6.050  1.000 21.687 0 193  ASN A CA  1 ? 
ATOM   1372 C C   . ASN A 1 189 ? 30.797  -47.770 -6.314  1.000 21.408 0 193  ASN A C   1 ? 
ATOM   1373 O O   . ASN A 1 189 ? 31.552  -48.675 -6.690  1.000 22.134 0 193  ASN A O   1 ? 
ATOM   1374 C CB  . ASN A 1 189 ? 28.771  -49.077 -7.046  1.000 21.005 0 193  ASN A CB  1 ? 
ATOM   1375 C CG  . ASN A 1 189 ? 27.541  -49.757 -6.493  1.000 26.506 0 193  ASN A CG  1 ? 
ATOM   1376 O OD1 . ASN A 1 189 ? 26.419  -49.453 -6.895  1.000 25.658 0 193  ASN A OD1 1 ? 
ATOM   1377 N ND2 . ASN A 1 189 ? 27.737  -50.619 -5.495  1.000 24.124 0 193  ASN A ND2 1 ? 
ATOM   1378 N N   . ALA A 1 190 ? 31.243  -46.542 -6.070  1.000 18.355 0 194  ALA A N   1 ? 
ATOM   1379 C CA  . ALA A 1 190 ? 32.644  -46.390 -5.698  1.000 20.666 0 194  ALA A CA  1 ? 
ATOM   1380 C C   . ALA A 1 190 ? 32.860  -47.172 -4.408  1.000 20.750 0 194  ALA A C   1 ? 
ATOM   1381 O O   . ALA A 1 190 ? 31.997  -47.171 -3.527  1.000 20.639 0 194  ALA A O   1 ? 
ATOM   1382 C CB  . ALA A 1 190 ? 32.990  -44.915 -5.498  1.000 21.713 0 194  ALA A CB  1 ? 
ATOM   1383 N N   . VAL A 1 191 ? 33.993  -47.878 -4.295  1.000 20.447 0 195  VAL A N   1 ? 
ATOM   1384 C CA  . VAL A 1 191 ? 34.236  -48.599 -3.045  1.000 19.268 0 195  VAL A CA  1 ? 
ATOM   1385 C C   . VAL A 1 191 ? 34.260  -47.625 -1.879  1.000 19.094 0 195  VAL A C   1 ? 
ATOM   1386 O O   . VAL A 1 191 ? 33.733  -47.913 -0.792  1.000 19.105 0 195  VAL A O   1 ? 
ATOM   1387 C CB  . VAL A 1 191 ? 35.547  -49.399 -3.118  1.000 23.108 0 195  VAL A CB  1 ? 
ATOM   1388 C CG1 . VAL A 1 191 ? 35.750  -50.157 -1.813  1.000 24.387 0 195  VAL A CG1 1 ? 
ATOM   1389 C CG2 . VAL A 1 191 ? 35.519  -50.337 -4.299  1.000 27.524 0 195  VAL A CG2 1 ? 
ATOM   1390 N N   . THR A 1 192 ? 34.861  -46.450 -2.090  1.000 19.921 0 196  THR A N   1 ? 
ATOM   1391 C CA  . THR A 1 192 ? 34.989  -45.452 -1.035  1.000 18.250 0 196  THR A CA  1 ? 
ATOM   1392 C C   . THR A 1 192 ? 33.692  -44.711 -0.763  1.000 20.231 0 196  THR A C   1 ? 
ATOM   1393 O O   . THR A 1 192 ? 33.689  -43.760 0.023   1.000 22.168 0 196  THR A O   1 ? 
ATOM   1394 C CB  . THR A 1 192 ? 36.106  -44.454 -1.365  1.000 17.602 0 196  THR A CB  1 ? 
ATOM   1395 O OG1 . THR A 1 192 ? 35.946  -43.940 -2.701  1.000 19.850 0 196  THR A OG1 1 ? 
ATOM   1396 C CG2 . THR A 1 192 ? 37.487  -45.135 -1.245  1.000 20.608 0 196  THR A CG2 1 ? 
ATOM   1397 N N   . LYS A 1 193 ? 32.597  -45.117 -1.404  1.000 19.284 0 197  LYS A N   1 ? 
ATOM   1398 C CA  . LYS A 1 193 ? 31.260  -44.676 -1.030  1.000 17.942 0 197  LYS A CA  1 ? 
ATOM   1399 C C   . LYS A 1 193 ? 30.514  -45.835 -0.375  1.000 18.715 0 197  LYS A C   1 ? 
ATOM   1400 O O   . LYS A 1 193 ? 30.287  -45.815 0.836   1.000 19.750 0 197  LYS A O   1 ? 
ATOM   1401 C CB  . LYS A 1 193 ? 30.527  -44.136 -2.270  1.000 18.897 0 197  LYS A CB  1 ? 
ATOM   1402 C CG  . LYS A 1 193 ? 29.317  -43.217 -1.962  1.000 19.055 0 197  LYS A CG  1 ? 
ATOM   1403 C CD  . LYS A 1 193 ? 28.157  -43.996 -1.357  1.000 16.481 0 197  LYS A CD  1 ? 
ATOM   1404 C CE  . LYS A 1 193 ? 26.927  -43.104 -1.144  1.000 16.997 0 197  LYS A CE  1 ? 
ATOM   1405 N NZ  . LYS A 1 193 ? 25.693  -43.927 -0.803  1.000 17.957 0 197  LYS A NZ  1 ? 
ATOM   1406 N N   . SER A 1 194 ? 30.164  -46.868 -1.146  1.000 18.550 0 198  SER A N   1 ? 
ATOM   1407 C CA  . SER A 1 194 ? 29.304  -47.952 -0.659  1.000 20.229 0 198  SER A CA  1 ? 
ATOM   1408 C C   . SER A 1 194 ? 29.844  -48.611 0.610   1.000 20.079 0 198  SER A C   1 ? 
ATOM   1409 O O   . SER A 1 194 ? 29.073  -48.930 1.525   1.000 20.905 0 198  SER A O   1 ? 
ATOM   1410 C CB  . SER A 1 194 ? 29.160  -49.006 -1.756  1.000 22.505 0 198  SER A CB  1 ? 
ATOM   1411 O OG  . SER A 1 194 ? 30.452  -49.406 -2.212  1.000 24.537 0 198  SER A OG  1 ? 
ATOM   1412 N N   . LYS A 1 195 ? 31.148  -48.883 0.661   1.000 18.563 0 199  LYS A N   1 ? 
ATOM   1413 C CA  . LYS A 1 195 ? 31.729  -49.619 1.781   1.000 20.108 0 199  LYS A CA  1 ? 
ATOM   1414 C C   . LYS A 1 195 ? 32.107  -48.719 2.947   1.000 19.871 0 199  LYS A C   1 ? 
ATOM   1415 O O   . LYS A 1 195 ? 32.687  -49.209 3.923   1.000 19.276 0 199  LYS A O   1 ? 
ATOM   1416 C CB  . LYS A 1 195 ? 32.957  -50.409 1.324   1.000 24.756 0 199  LYS A CB  1 ? 
ATOM   1417 C CG  . LYS A 1 195 ? 32.663  -51.383 0.185   1.000 28.143 0 199  LYS A CG  1 ? 
ATOM   1418 C CD  . LYS A 1 195 ? 31.844  -52.553 0.663   1.000 41.605 0 199  LYS A CD  1 ? 
ATOM   1419 C CE  . LYS A 1 195 ? 32.730  -53.521 1.424   1.000 43.589 0 199  LYS A CE  1 ? 
ATOM   1420 N NZ  . LYS A 1 195 ? 32.085  -54.856 1.581   1.000 43.576 0 199  LYS A NZ  1 ? 
ATOM   1421 N N   . PHE A 1 196 ? 31.782  -47.424 2.878   1.000 17.915 0 200  PHE A N   1 ? 
ATOM   1422 C CA  . PHE A 1 196 ? 32.164  -46.495 3.936   1.000 16.636 0 200  PHE A CA  1 ? 
ATOM   1423 C C   . PHE A 1 196 ? 30.947  -45.721 4.421   1.000 19.273 0 200  PHE A C   1 ? 
ATOM   1424 O O   . PHE A 1 196 ? 30.458  -45.975 5.524   1.000 19.639 0 200  PHE A O   1 ? 
ATOM   1425 C CB  . PHE A 1 196 ? 33.285  -45.573 3.445   1.000 18.115 0 200  PHE A CB  1 ? 
ATOM   1426 C CG  . PHE A 1 196 ? 34.592  -46.300 3.270   1.000 18.794 0 200  PHE A CG  1 ? 
ATOM   1427 C CD1 . PHE A 1 196 ? 34.846  -47.016 2.108   1.000 20.142 0 200  PHE A CD1 1 ? 
ATOM   1428 C CD2 . PHE A 1 196 ? 35.518  -46.345 4.302   1.000 17.705 0 200  PHE A CD2 1 ? 
ATOM   1429 C CE1 . PHE A 1 196 ? 36.045  -47.718 1.947   1.000 21.745 0 200  PHE A CE1 1 ? 
ATOM   1430 C CE2 . PHE A 1 196 ? 36.711  -47.058 4.157   1.000 19.566 0 200  PHE A CE2 1 ? 
ATOM   1431 C CZ  . PHE A 1 196 ? 36.976  -47.737 2.982   1.000 20.295 0 200  PHE A CZ  1 ? 
ATOM   1432 N N   . ASP A 1 197 ? 30.429  -44.816 3.587   1.000 16.841 0 201  ASP A N   1 ? 
ATOM   1433 C CA  . ASP A 1 197 ? 29.175  -44.112 3.874   1.000 16.294 0 201  ASP A CA  1 ? 
ATOM   1434 C C   . ASP A 1 197 ? 28.050  -45.075 4.270   1.000 20.481 0 201  ASP A C   1 ? 
ATOM   1435 O O   . ASP A 1 197 ? 27.502  -44.992 5.378   1.000 19.000 0 201  ASP A O   1 ? 
ATOM   1436 C CB  . ASP A 1 197 ? 28.833  -43.288 2.619   1.000 20.426 0 201  ASP A CB  1 ? 
ATOM   1437 C CG  . ASP A 1 197 ? 27.494  -42.547 2.673   1.000 26.406 0 201  ASP A CG  1 ? 
ATOM   1438 O OD1 . ASP A 1 197 ? 26.499  -43.038 3.241   1.000 27.751 0 201  ASP A OD1 1 ? 
ATOM   1439 O OD2 . ASP A 1 197 ? 27.425  -41.477 2.023   1.000 23.303 0 201  ASP A OD2 1 ? 
ATOM   1440 N N   . ASN A 1 198 ? 27.688  -46.002 3.376   1.000 17.063 0 202  ASN A N   1 ? 
ATOM   1441 C CA  . ASN A 1 198 ? 26.501  -46.823 3.635   1.000 18.223 0 202  ASN A CA  1 ? 
ATOM   1442 C C   . ASN A 1 198 ? 26.674  -47.657 4.898   1.000 19.879 0 202  ASN A C   1 ? 
ATOM   1443 O O   . ASN A 1 198 ? 25.714  -47.864 5.653   1.000 20.629 0 202  ASN A O   1 ? 
ATOM   1444 C CB  . ASN A 1 198 ? 26.207  -47.749 2.453   1.000 19.321 0 202  ASN A CB  1 ? 
ATOM   1445 C CG  . ASN A 1 198 ? 25.986  -46.999 1.143   1.000 20.947 0 202  ASN A CG  1 ? 
ATOM   1446 O OD1 . ASN A 1 198 ? 26.509  -45.910 0.948   1.000 19.552 0 202  ASN A OD1 1 ? 
ATOM   1447 N ND2 . ASN A 1 198 ? 25.191  -47.587 0.247   1.000 20.013 0 202  ASN A ND2 1 ? 
ATOM   1448 N N   . LEU A 1 199 ? 27.900  -48.128 5.145   1.000 17.020 0 203  LEU A N   1 ? 
ATOM   1449 C CA  . LEU A 1 199 ? 28.204  -49.052 6.246   1.000 17.621 0 203  LEU A CA  1 ? 
ATOM   1450 C C   . LEU A 1 199 ? 28.565  -48.307 7.529   1.000 17.684 0 203  LEU A C   1 ? 
ATOM   1451 O O   . LEU A 1 199 ? 27.813  -48.335 8.509   1.000 17.647 0 203  LEU A O   1 ? 
ATOM   1452 C CB  . LEU A 1 199 ? 29.348  -49.977 5.815   1.000 17.857 0 203  LEU A CB  1 ? 
ATOM   1453 C CG  . LEU A 1 199 ? 29.854  -50.968 6.854   1.000 20.218 0 203  LEU A CG  1 ? 
ATOM   1454 C CD1 . LEU A 1 199 ? 28.797  -52.013 7.087   1.000 21.008 0 203  LEU A CD1 1 ? 
ATOM   1455 C CD2 . LEU A 1 199 ? 31.152  -51.614 6.356   1.000 21.971 0 203  LEU A CD2 1 ? 
ATOM   1456 N N   . TYR A 1 200 ? 29.723  -47.631 7.532   1.000 17.147 0 204  TYR A N   1 ? 
ATOM   1457 C CA  . TYR A 1 200 ? 30.187  -46.957 8.745   1.000 15.723 0 204  TYR A CA  1 ? 
ATOM   1458 C C   . TYR A 1 200 ? 29.371  -45.712 9.058   1.000 16.957 0 204  TYR A C   1 ? 
ATOM   1459 O O   . TYR A 1 200 ? 29.228  -45.344 10.230  1.000 18.526 0 204  TYR A O   1 ? 
ATOM   1460 C CB  . TYR A 1 200 ? 31.657  -46.558 8.607   1.000 16.618 0 204  TYR A CB  1 ? 
ATOM   1461 C CG  . TYR A 1 200 ? 32.576  -47.711 8.258   1.000 16.547 0 204  TYR A CG  1 ? 
ATOM   1462 C CD1 . TYR A 1 200 ? 32.568  -48.884 9.007   1.000 20.613 0 204  TYR A CD1 1 ? 
ATOM   1463 C CD2 . TYR A 1 200 ? 33.460  -47.613 7.190   1.000 20.089 0 204  TYR A CD2 1 ? 
ATOM   1464 C CE1 . TYR A 1 200 ? 33.421  -49.939 8.693   1.000 20.197 0 204  TYR A CE1 1 ? 
ATOM   1465 C CE2 . TYR A 1 200 ? 34.314  -48.656 6.868   1.000 20.302 0 204  TYR A CE2 1 ? 
ATOM   1466 C CZ  . TYR A 1 200 ? 34.283  -49.817 7.622   1.000 20.329 0 204  TYR A CZ  1 ? 
ATOM   1467 O OH  . TYR A 1 200 ? 35.123  -50.859 7.300   1.000 22.797 0 204  TYR A OH  1 ? 
ATOM   1468 N N   . GLY A 1 201 ? 28.879  -45.021 8.033   1.000 17.057 0 205  GLY A N   1 ? 
ATOM   1469 C CA  . GLY A 1 201 ? 28.010  -43.886 8.288   1.000 17.371 0 205  GLY A CA  1 ? 
ATOM   1470 C C   . GLY A 1 201 ? 26.764  -44.297 9.048   1.000 18.507 0 205  GLY A C   1 ? 
ATOM   1471 O O   . GLY A 1 201 ? 26.459  -43.749 10.114  1.000 18.815 0 205  GLY A O   1 ? 
ATOM   1472 N N   . CYS A 1 202 ? 26.040  -45.296 8.530   1.000 16.707 0 206  CYS A N   1 ? 
ATOM   1473 C CA  . CYS A 1 202 ? 24.821  -45.727 9.220   1.000 17.020 0 206  CYS A CA  1 ? 
ATOM   1474 C C   . CYS A 1 202 ? 25.131  -46.376 10.563  1.000 16.307 0 206  CYS A C   1 ? 
ATOM   1475 O O   . CYS A 1 202 ? 24.305  -46.309 11.481  1.000 19.452 0 206  CYS A O   1 ? 
ATOM   1476 C CB  . CYS A 1 202 ? 24.022  -46.693 8.345   1.000 18.792 0 206  CYS A CB  1 ? 
ATOM   1477 S SG  . CYS A 1 202 ? 23.323  -45.892 6.890   1.000 22.963 0 206  CYS A SG  1 ? 
ATOM   1478 N N   . ARG A 1 203 ? 26.308  -47.012 10.699  1.000 16.739 0 207  ARG A N   1 ? 
ATOM   1479 C CA  . ARG A 1 203 ? 26.694  -47.573 11.991  1.000 16.052 0 207  ARG A CA  1 ? 
ATOM   1480 C C   . ARG A 1 203 ? 26.658  -46.512 13.081  1.000 19.576 0 207  ARG A C   1 ? 
ATOM   1481 O O   . ARG A 1 203 ? 26.411  -46.826 14.254  1.000 19.460 0 207  ARG A O   1 ? 
ATOM   1482 C CB  . ARG A 1 203 ? 28.099  -48.194 11.909  1.000 16.713 0 207  ARG A CB  1 ? 
ATOM   1483 C CG  . ARG A 1 203 ? 28.508  -48.932 13.183  1.000 16.252 0 207  ARG A CG  1 ? 
ATOM   1484 C CD  . ARG A 1 203 ? 29.815  -49.701 12.985  1.000 17.486 0 207  ARG A CD  1 ? 
ATOM   1485 N NE  . ARG A 1 203 ? 30.954  -48.796 12.804  1.000 16.570 0 207  ARG A NE  1 ? 
ATOM   1486 C CZ  . ARG A 1 203 ? 32.179  -49.217 12.506  1.000 18.289 0 207  ARG A CZ  1 ? 
ATOM   1487 N NH1 . ARG A 1 203 ? 32.415  -50.515 12.350  1.000 21.118 0 207  ARG A NH1 1 ? 
ATOM   1488 N NH2 . ARG A 1 203 ? 33.168  -48.338 12.363  1.000 18.702 0 207  ARG A NH2 1 ? 
ATOM   1489 N N   . GLU A 1 204 ? 26.909  -45.256 12.721  1.000 18.681 0 208  GLU A N   1 ? 
ATOM   1490 C CA  . GLU A 1 204 ? 26.833  -44.172 13.689  1.000 18.605 0 208  GLU A CA  1 ? 
ATOM   1491 C C   . GLU A 1 204 ? 25.510  -43.428 13.637  1.000 20.410 0 208  GLU A C   1 ? 
ATOM   1492 O O   . GLU A 1 204 ? 24.968  -43.086 14.691  1.000 19.639 0 208  GLU A O   1 ? 
ATOM   1493 C CB  . GLU A 1 204 ? 27.992  -43.192 13.479  1.000 19.889 0 208  GLU A CB  1 ? 
ATOM   1494 C CG  . GLU A 1 204 ? 29.306  -43.905 13.807  1.000 19.260 0 208  GLU A CG  1 ? 
ATOM   1495 C CD  . GLU A 1 204 ? 30.531  -43.019 13.806  1.000 20.466 0 208  GLU A CD  1 ? 
ATOM   1496 O OE1 . GLU A 1 204 ? 31.604  -43.559 13.446  1.000 19.415 0 208  GLU A OE1 1 ? 
ATOM   1497 O OE2 . GLU A 1 204 ? 30.436  -41.819 14.162  1.000 22.418 0 208  GLU A OE2 1 ? 
ATOM   1498 N N   . SER A 1 205 ? 24.966  -43.186 12.446  1.000 18.465 0 209  SER A N   1 ? 
ATOM   1499 C CA  . SER A 1 205 ? 23.837  -42.262 12.351  1.000 18.184 0 209  SER A CA  1 ? 
ATOM   1500 C C   . SER A 1 205 ? 22.473  -42.911 12.612  1.000 18.065 0 209  SER A C   1 ? 
ATOM   1501 O O   . SER A 1 205 ? 21.523  -42.194 12.943  1.000 19.097 0 209  SER A O   1 ? 
ATOM   1502 C CB  . SER A 1 205 ? 23.852  -41.547 10.988  1.000 19.026 0 209  SER A CB  1 ? 
ATOM   1503 O OG  . SER A 1 205 ? 23.688  -42.435 9.903   1.000 22.713 0 209  SER A OG  1 ? 
ATOM   1504 N N   . LEU A 1 206 ? 22.336  -44.238 12.505  1.000 18.700 0 210  LEU A N   1 ? 
ATOM   1505 C CA  . LEU A 1 206 ? 21.098  -44.862 12.984  1.000 18.860 0 210  LEU A CA  1 ? 
ATOM   1506 C C   . LEU A 1 206 ? 20.928  -44.636 14.482  1.000 20.016 0 210  LEU A C   1 ? 
ATOM   1507 O O   . LEU A 1 206 ? 19.858  -44.228 14.946  1.000 20.176 0 210  LEU A O   1 ? 
ATOM   1508 C CB  . LEU A 1 206 ? 21.087  -46.362 12.676  1.000 21.142 0 210  LEU A CB  1 ? 
ATOM   1509 C CG  . LEU A 1 206 ? 19.962  -47.094 13.434  1.000 19.626 0 210  LEU A CG  1 ? 
ATOM   1510 C CD1 . LEU A 1 206 ? 18.589  -46.667 12.899  1.000 21.203 0 210  LEU A CD1 1 ? 
ATOM   1511 C CD2 . LEU A 1 206 ? 20.130  -48.606 13.372  1.000 21.963 0 210  LEU A CD2 1 ? 
ATOM   1512 N N   . LEU A 1 207 ? 21.982  -44.910 15.257  1.000 23.053 0 211  LEU A N   1 ? 
ATOM   1513 C CA  . LEU A 1 207 ? 21.933  -44.680 16.697  1.000 22.100 0 211  LEU A CA  1 ? 
ATOM   1514 C C   . LEU A 1 207 ? 21.602  -43.234 17.007  1.000 21.884 0 211  LEU A C   1 ? 
ATOM   1515 O O   . LEU A 1 207 ? 20.842  -42.948 17.935  1.000 24.221 0 211  LEU A O   1 ? 
ATOM   1516 C CB  . LEU A 1 207 ? 23.277  -45.024 17.334  1.000 24.321 0 211  LEU A CB  1 ? 
ATOM   1517 C CG  . LEU A 1 207 ? 23.697  -46.479 17.344  1.000 26.461 0 211  LEU A CG  1 ? 
ATOM   1518 C CD1 . LEU A 1 207 ? 25.032  -46.578 18.080  1.000 20.968 0 211  LEU A CD1 1 ? 
ATOM   1519 C CD2 . LEU A 1 207 ? 22.642  -47.314 18.023  1.000 26.398 0 211  LEU A CD2 1 ? 
ATOM   1520 N N   . ASP A 1 208 ? 22.216  -42.312 16.267  1.000 21.284 0 212  ASP A N   1 ? 
ATOM   1521 C CA  . ASP A 1 208 ? 21.952  -40.890 16.441  1.000 23.319 0 212  ASP A CA  1 ? 
ATOM   1522 C C   . ASP A 1 208 ? 20.464  -40.592 16.315  1.000 24.363 0 212  ASP A C   1 ? 
ATOM   1523 O O   . ASP A 1 208 ? 19.862  -39.951 17.189  1.000 23.613 0 212  ASP A O   1 ? 
ATOM   1524 C CB  . ASP A 1 208 ? 22.741  -40.113 15.395  1.000 26.214 0 212  ASP A CB  1 ? 
ATOM   1525 C CG  . ASP A 1 208 ? 23.076  -38.726 15.840  1.000 36.723 0 212  ASP A CG  1 ? 
ATOM   1526 O OD1 . ASP A 1 208 ? 22.592  -38.318 16.920  1.000 35.925 0 212  ASP A OD1 1 ? 
ATOM   1527 O OD2 . ASP A 1 208 ? 23.826  -38.049 15.108  1.000 40.734 0 212  ASP A OD2 1 ? 
ATOM   1528 N N   . GLY A 1 209 ? 19.848  -41.068 15.231  1.000 20.492 0 213  GLY A N   1 ? 
ATOM   1529 C CA  . GLY A 1 209 ? 18.418  -40.835 15.050  1.000 18.994 0 213  GLY A CA  1 ? 
ATOM   1530 C C   . GLY A 1 209 ? 17.572  -41.450 16.151  1.000 20.789 0 213  GLY A C   1 ? 
ATOM   1531 O O   . GLY A 1 209 ? 16.640  -40.820 16.662  1.000 20.645 0 213  GLY A O   1 ? 
ATOM   1532 N N   . LEU A 1 210 ? 17.871  -42.701 16.522  1.000 22.213 0 214  LEU A N   1 ? 
ATOM   1533 C CA  . LEU A 1 210 ? 17.083  -43.365 17.562  1.000 23.271 0 214  LEU A CA  1 ? 
ATOM   1534 C C   . LEU A 1 210 ? 17.207  -42.646 18.898  1.000 22.268 0 214  LEU A C   1 ? 
ATOM   1535 O O   . LEU A 1 210 ? 16.207  -42.459 19.606  1.000 25.756 0 214  LEU A O   1 ? 
ATOM   1536 C CB  . LEU A 1 210 ? 17.529  -44.817 17.725  1.000 22.171 0 214  LEU A CB  1 ? 
ATOM   1537 C CG  . LEU A 1 210 ? 17.151  -45.814 16.638  1.000 22.932 0 214  LEU A CG  1 ? 
ATOM   1538 C CD1 . LEU A 1 210 ? 17.890  -47.135 16.866  1.000 26.164 0 214  LEU A CD1 1 ? 
ATOM   1539 C CD2 . LEU A 1 210 ? 15.662  -46.067 16.607  1.000 23.892 0 214  LEU A CD2 1 ? 
ATOM   1540 N N   . LYS A 1 211 ? 18.429  -42.257 19.265  1.000 24.842 0 215  LYS A N   1 ? 
ATOM   1541 C CA  . LYS A 1 211 ? 18.670  -41.658 20.573  1.000 25.511 0 215  LYS A CA  1 ? 
ATOM   1542 C C   . LYS A 1 211 ? 18.090  -40.254 20.661  1.000 27.793 0 215  LYS A C   1 ? 
ATOM   1543 O O   . LYS A 1 211 ? 17.546  -39.867 21.703  1.000 31.243 0 215  LYS A O   1 ? 
ATOM   1544 C CB  . LYS A 1 211 ? 20.169  -41.639 20.868  1.000 27.706 0 215  LYS A CB  1 ? 
ATOM   1545 C CG  . LYS A 1 211 ? 20.721  -43.013 21.222  1.000 29.843 0 215  LYS A CG  1 ? 
ATOM   1546 C CD  . LYS A 1 211 ? 22.231  -42.982 21.383  1.000 37.773 0 215  LYS A CD  1 ? 
ATOM   1547 C CE  . LYS A 1 211 ? 22.766  -44.378 21.705  1.000 38.705 0 215  LYS A CE  1 ? 
ATOM   1548 N NZ  . LYS A 1 211 ? 24.239  -44.392 21.826  1.000 27.366 0 215  LYS A NZ  1 ? 
ATOM   1549 N N   . ARG A 1 212 ? 18.190  -39.468 19.588  1.000 22.637 0 216  ARG A N   1 ? 
ATOM   1550 C CA  . ARG A 1 212 ? 17.593  -38.138 19.647  1.000 22.139 0 216  ARG A CA  1 ? 
ATOM   1551 C C   . ARG A 1 212 ? 16.076  -38.214 19.719  1.000 24.295 0 216  ARG A C   1 ? 
ATOM   1552 O O   . ARG A 1 212 ? 15.446  -37.387 20.388  1.000 26.724 0 216  ARG A O   1 ? 
ATOM   1553 C CB  . ARG A 1 212 ? 18.021  -37.303 18.443  1.000 23.276 0 216  ARG A CB  1 ? 
ATOM   1554 C CG  . ARG A 1 212 ? 19.506  -37.039 18.416  1.000 28.772 0 216  ARG A CG  1 ? 
ATOM   1555 C CD  . ARG A 1 212 ? 19.849  -35.871 17.503  1.000 36.523 0 216  ARG A CD  1 ? 
ATOM   1556 N NE  . ARG A 1 212 ? 21.161  -36.055 16.881  1.000 44.566 0 216  ARG A NE  1 ? 
ATOM   1557 C CZ  . ARG A 1 212 ? 21.873  -35.074 16.339  1.000 43.492 0 216  ARG A CZ  1 ? 
ATOM   1558 N NH1 . ARG A 1 212 ? 21.406  -33.832 16.352  1.000 46.027 0 216  ARG A NH1 1 ? 
ATOM   1559 N NH2 . ARG A 1 212 ? 23.055  -35.333 15.793  1.000 47.558 0 216  ARG A NH2 1 ? 
ATOM   1560 N N   . ALA A 1 213 ? 15.476  -39.217 19.076  1.000 22.103 0 217  ALA A N   1 ? 
ATOM   1561 C CA  . ALA A 1 213 ? 14.022  -39.280 18.985  1.000 23.321 0 217  ALA A CA  1 ? 
ATOM   1562 C C   . ALA A 1 213 ? 13.374  -39.729 20.292  1.000 26.229 0 217  ALA A C   1 ? 
ATOM   1563 O O   . ALA A 1 213 ? 12.320  -39.205 20.674  1.000 24.000 0 217  ALA A O   1 ? 
ATOM   1564 C CB  . ALA A 1 213 ? 13.618  -40.219 17.847  1.000 24.490 0 217  ALA A CB  1 ? 
ATOM   1565 N N   . THR A 1 214 ? 13.949  -40.727 20.971  1.000 27.340 0 218  THR A N   1 ? 
ATOM   1566 C CA  . THR A 1 214 ? 13.319  -41.309 22.155  1.000 24.856 0 218  THR A CA  1 ? 
ATOM   1567 C C   . THR A 1 214 ? 14.353  -41.563 23.245  1.000 27.474 0 218  THR A C   1 ? 
ATOM   1568 O O   . THR A 1 214 ? 15.559  -41.586 23.005  1.000 26.982 0 218  THR A O   1 ? 
ATOM   1569 C CB  . THR A 1 214 ? 12.599  -42.635 21.843  1.000 34.665 0 218  THR A CB  1 ? 
ATOM   1570 O OG1 . THR A 1 214 ? 13.547  -43.705 21.872  1.000 37.131 0 218  THR A OG1 1 ? 
ATOM   1571 C CG2 . THR A 1 214 ? 11.921  -42.618 20.470  1.000 36.125 0 218  THR A CG2 1 ? 
ATOM   1572 N N   . ASP A 1 215 ? 13.876  -41.804 24.463  1.000 29.722 0 219  ASP A N   1 ? 
ATOM   1573 C CA  . ASP A 1 215 ? 14.792  -42.219 25.524  1.000 35.910 0 219  ASP A CA  1 ? 
ATOM   1574 C C   . ASP A 1 215 ? 14.757  -43.726 25.716  1.000 41.700 0 219  ASP A C   1 ? 
ATOM   1575 O O   . ASP A 1 215 ? 14.870  -44.245 26.837  1.000 34.994 0 219  ASP A O   1 ? 
ATOM   1576 C CB  . ASP A 1 215 ? 14.494  -41.478 26.823  1.000 39.721 0 219  ASP A CB  1 ? 
ATOM   1577 C CG  . ASP A 1 215 ? 15.042  -40.056 26.804  1.000 50.285 0 219  ASP A CG  1 ? 
ATOM   1578 O OD1 . ASP A 1 215 ? 15.756  -39.718 25.829  1.000 50.182 0 219  ASP A OD1 1 ? 
ATOM   1579 O OD2 . ASP A 1 215 ? 14.765  -39.283 27.750  1.000 52.588 0 219  ASP A OD2 1 ? 
ATOM   1580 N N   . VAL A 1 216 ? 14.601  -44.446 24.609  1.000 45.098 0 220  VAL A N   1 ? 
ATOM   1581 C CA  . VAL A 1 216 ? 14.622  -45.899 24.641  1.000 42.545 0 220  VAL A CA  1 ? 
ATOM   1582 C C   . VAL A 1 216 ? 16.063  -46.373 24.735  1.000 31.406 0 220  VAL A C   1 ? 
ATOM   1583 O O   . VAL A 1 216 ? 16.964  -45.881 24.042  1.000 44.576 0 220  VAL A O   1 ? 
ATOM   1584 C CB  . VAL A 1 216 ? 13.912  -46.499 23.417  1.000 48.074 0 220  VAL A CB  1 ? 
ATOM   1585 C CG1 . VAL A 1 216 ? 14.870  -46.617 22.227  1.000 52.472 0 220  VAL A CG1 1 ? 
ATOM   1586 C CG2 . VAL A 1 216 ? 13.345  -47.864 23.775  1.000 37.999 0 220  VAL A CG2 1 ? 
ATOM   1587 N N   . MET A 1 217 ? 16.294  -47.283 25.657  1.000 22.663 0 221  MET A N   1 ? 
ATOM   1588 C CA  . MET A 1 217 ? 17.578  -47.939 25.777  1.000 23.777 0 221  MET A CA  1 ? 
ATOM   1589 C C   . MET A 1 217 ? 17.718  -48.976 24.676  1.000 20.545 0 221  MET A C   1 ? 
ATOM   1590 O O   . MET A 1 217 ? 16.749  -49.661 24.354  1.000 23.082 0 221  MET A O   1 ? 
ATOM   1591 C CB  . MET A 1 217 ? 17.642  -48.607 27.146  1.000 26.353 0 221  MET A CB  1 ? 
ATOM   1592 C CG  . MET A 1 217 ? 18.872  -49.359 27.397  1.000 27.656 0 221  MET A CG  1 ? 
ATOM   1593 S SD  . MET A 1 217 ? 18.992  -49.505 29.160  1.000 34.549 0 221  MET A SD  1 ? 
ATOM   1594 C CE  . MET A 1 217 ? 20.661  -48.883 29.391  1.000 47.177 0 221  MET A CE  1 ? 
ATOM   1595 N N   . ILE A 1 218 ? 18.926  -49.109 24.114  1.000 19.239 0 222  ILE A N   1 ? 
ATOM   1596 C CA  . ILE A 1 218 ? 19.168  -50.175 23.141  1.000 19.408 0 222  ILE A CA  1 ? 
ATOM   1597 C C   . ILE A 1 218 ? 19.447  -51.499 23.844  1.000 20.642 0 222  ILE A C   1 ? 
ATOM   1598 O O   . ILE A 1 218 ? 18.948  -52.559 23.431  1.000 19.181 0 222  ILE A O   1 ? 
ATOM   1599 C CB  . ILE A 1 218 ? 20.337  -49.802 22.210  1.000 19.229 0 222  ILE A CB  1 ? 
ATOM   1600 C CG1 . ILE A 1 218 ? 20.093  -48.439 21.577  1.000 26.769 0 222  ILE A CG1 1 ? 
ATOM   1601 C CG2 . ILE A 1 218 ? 20.532  -50.885 21.147  1.000 19.866 0 222  ILE A CG2 1 ? 
ATOM   1602 C CD1 . ILE A 1 218 ? 18.910  -48.395 20.693  1.000 26.611 0 222  ILE A CD1 1 ? 
ATOM   1603 N N   . ALA A 1 219 ? 20.263  -51.461 24.896  1.000 18.663 0 223  ALA A N   1 ? 
ATOM   1604 C CA  . ALA A 1 219 ? 20.678  -52.682 25.588  1.000 16.915 0 223  ALA A CA  1 ? 
ATOM   1605 C C   . ALA A 1 219 ? 19.476  -53.488 26.053  1.000 18.623 0 223  ALA A C   1 ? 
ATOM   1606 O O   . ALA A 1 219 ? 18.545  -52.948 26.663  1.000 20.342 0 223  ALA A O   1 ? 
ATOM   1607 C CB  . ALA A 1 219 ? 21.547  -52.329 26.793  1.000 18.063 0 223  ALA A CB  1 ? 
ATOM   1608 N N   . GLY A 1 220 ? 19.513  -54.797 25.786  1.000 16.544 0 224  GLY A N   1 ? 
ATOM   1609 C CA  . GLY A 1 220 ? 18.438  -55.687 26.194  1.000 16.378 0 224  GLY A CA  1 ? 
ATOM   1610 C C   . GLY A 1 220 ? 17.258  -55.757 25.247  1.000 18.921 0 224  GLY A C   1 ? 
ATOM   1611 O O   . GLY A 1 220 ? 16.433  -56.675 25.372  1.000 19.279 0 224  GLY A O   1 ? 
ATOM   1612 N N   . LYS A 1 221 ? 17.147  -54.833 24.296  1.000 17.110 0 225  LYS A N   1 ? 
ATOM   1613 C CA  . LYS A 1 221 ? 16.034  -54.848 23.359  1.000 17.068 0 225  LYS A CA  1 ? 
ATOM   1614 C C   . LYS A 1 221 ? 16.244  -55.900 22.280  1.000 17.823 0 225  LYS A C   1 ? 
ATOM   1615 O O   . LYS A 1 221 ? 17.371  -56.280 21.951  1.000 18.150 0 225  LYS A O   1 ? 
ATOM   1616 C CB  . LYS A 1 221 ? 15.875  -53.479 22.686  1.000 19.071 0 225  LYS A CB  1 ? 
ATOM   1617 C CG  . LYS A 1 221 ? 15.510  -52.346 23.649  1.000 20.616 0 225  LYS A CG  1 ? 
ATOM   1618 C CD  . LYS A 1 221 ? 14.291  -52.707 24.497  1.000 22.626 0 225  LYS A CD  1 ? 
ATOM   1619 C CE  . LYS A 1 221 ? 13.648  -51.474 25.152  1.000 23.140 0 225  LYS A CE  1 ? 
ATOM   1620 N NZ  . LYS A 1 221 ? 14.618  -50.652 25.930  1.000 23.932 0 225  LYS A NZ  1 ? 
ATOM   1621 N N   . VAL A 1 222 ? 15.135  -56.351 21.703  1.000 16.963 0 226  VAL A N   1 ? 
ATOM   1622 C CA  . VAL A 1 222 ? 15.168  -57.167 20.496  1.000 18.128 0 226  VAL A CA  1 ? 
ATOM   1623 C C   . VAL A 1 222 ? 14.923  -56.246 19.314  1.000 18.018 0 226  VAL A C   1 ? 
ATOM   1624 O O   . VAL A 1 222 ? 13.845  -55.651 19.195  1.000 19.616 0 226  VAL A O   1 ? 
ATOM   1625 C CB  . VAL A 1 222 ? 14.118  -58.285 20.546  1.000 19.087 0 226  VAL A CB  1 ? 
ATOM   1626 C CG1 . VAL A 1 222 ? 14.093  -59.044 19.212  1.000 21.479 0 226  VAL A CG1 1 ? 
ATOM   1627 C CG2 . VAL A 1 222 ? 14.401  -59.207 21.731  1.000 19.421 0 226  VAL A CG2 1 ? 
ATOM   1628 N N   . ALA A 1 223 ? 15.922  -56.115 18.443  1.000 17.097 0 227  ALA A N   1 ? 
ATOM   1629 C CA  . ALA A 1 223 ? 15.840  -55.213 17.302  1.000 16.439 0 227  ALA A CA  1 ? 
ATOM   1630 C C   . ALA A 1 223 ? 15.873  -56.027 16.020  1.000 21.750 0 227  ALA A C   1 ? 
ATOM   1631 O O   . ALA A 1 223 ? 16.725  -56.905 15.870  1.000 23.237 0 227  ALA A O   1 ? 
ATOM   1632 C CB  . ALA A 1 223 ? 17.001  -54.211 17.319  1.000 16.920 0 227  ALA A CB  1 ? 
ATOM   1633 N N   . LEU A 1 224 ? 14.969  -55.723 15.089  1.000 16.957 0 228  LEU A N   1 ? 
ATOM   1634 C CA  . LEU A 1 224 ? 14.915  -56.403 13.796  1.000 17.484 0 228  LEU A CA  1 ? 
ATOM   1635 C C   . LEU A 1 224 ? 15.352  -55.430 12.714  1.000 18.529 0 228  LEU A C   1 ? 
ATOM   1636 O O   . LEU A 1 224 ? 14.780  -54.345 12.586  1.000 19.471 0 228  LEU A O   1 ? 
ATOM   1637 C CB  . LEU A 1 224 ? 13.502  -56.910 13.503  1.000 16.347 0 228  LEU A CB  1 ? 
ATOM   1638 C CG  . LEU A 1 224 ? 13.265  -57.503 12.112  1.000 18.313 0 228  LEU A CG  1 ? 
ATOM   1639 C CD1 . LEU A 1 224 ? 14.088  -58.780 11.868  1.000 18.000 0 228  LEU A CD1 1 ? 
ATOM   1640 C CD2 . LEU A 1 224 ? 11.759  -57.791 11.943  1.000 19.137 0 228  LEU A CD2 1 ? 
ATOM   1641 N N   . ILE A 1 225 ? 16.359  -55.822 11.939  1.000 16.497 0 229  ILE A N   1 ? 
ATOM   1642 C CA  . ILE A 1 225 ? 16.815  -55.068 10.776  1.000 15.276 0 229  ILE A CA  1 ? 
ATOM   1643 C C   . ILE A 1 225 ? 16.316  -55.790 9.535   1.000 16.818 0 229  ILE A C   1 ? 
ATOM   1644 O O   . ILE A 1 225 ? 16.645  -56.965 9.327   1.000 17.802 0 229  ILE A O   1 ? 
ATOM   1645 C CB  . ILE A 1 225 ? 18.346  -54.963 10.741  1.000 19.431 0 229  ILE A CB  1 ? 
ATOM   1646 C CG1 . ILE A 1 225 ? 18.899  -54.393 12.050  1.000 24.111 0 229  ILE A CG1 1 ? 
ATOM   1647 C CG2 . ILE A 1 225 ? 18.785  -54.153 9.532   1.000 19.065 0 229  ILE A CG2 1 ? 
ATOM   1648 C CD1 . ILE A 1 225 ? 18.510  -52.998 12.305  1.000 27.237 0 229  ILE A CD1 1 ? 
ATOM   1649 N N   . LEU A 1 226 ? 15.533  -55.104 8.698   1.000 17.194 0 230  LEU A N   1 ? 
ATOM   1650 C CA  . LEU A 1 226 ? 15.086  -55.685 7.434   1.000 17.034 0 230  LEU A CA  1 ? 
ATOM   1651 C C   . LEU A 1 226 ? 16.079  -55.270 6.353   1.000 17.399 0 230  LEU A C   1 ? 
ATOM   1652 O O   . LEU A 1 226 ? 16.209  -54.083 6.046   1.000 18.052 0 230  LEU A O   1 ? 
ATOM   1653 C CB  . LEU A 1 226 ? 13.666  -55.230 7.083   1.000 16.676 0 230  LEU A CB  1 ? 
ATOM   1654 C CG  . LEU A 1 226 ? 12.561  -55.385 8.118   1.000 21.676 0 230  LEU A CG  1 ? 
ATOM   1655 C CD1 . LEU A 1 226 ? 11.208  -55.057 7.476   1.000 23.198 0 230  LEU A CD1 1 ? 
ATOM   1656 C CD2 . LEU A 1 226 ? 12.526  -56.801 8.631   1.000 27.380 0 230  LEU A CD2 1 ? 
ATOM   1657 N N   . GLY A 1 227 ? 16.794  -56.248 5.793   1.000 17.244 0 231  GLY A N   1 ? 
ATOM   1658 C CA  . GLY A 1 227 ? 17.832  -55.979 4.808   1.000 16.689 0 231  GLY A CA  1 ? 
ATOM   1659 C C   . GLY A 1 227 ? 19.216  -56.031 5.422   1.000 18.665 0 231  GLY A C   1 ? 
ATOM   1660 O O   . GLY A 1 227 ? 19.459  -55.418 6.467   1.000 18.605 0 231  GLY A O   1 ? 
ATOM   1661 N N   . TYR A 1 228 ? 20.123  -56.771 4.789   1.000 16.360 0 232  TYR A N   1 ? 
ATOM   1662 C CA  . TYR A 1 228 ? 21.494  -56.946 5.279   1.000 16.012 0 232  TYR A CA  1 ? 
ATOM   1663 C C   . TYR A 1 228 ? 22.476  -56.665 4.151   1.000 17.421 0 232  TYR A C   1 ? 
ATOM   1664 O O   . TYR A 1 228 ? 23.443  -57.409 3.916   1.000 17.160 0 232  TYR A O   1 ? 
ATOM   1665 C CB  . TYR A 1 228 ? 21.682  -58.345 5.890   1.000 16.755 0 232  TYR A CB  1 ? 
ATOM   1666 C CG  . TYR A 1 228 ? 22.888  -58.439 6.814   1.000 16.181 0 232  TYR A CG  1 ? 
ATOM   1667 C CD1 . TYR A 1 228 ? 22.906  -57.784 8.041   1.000 16.513 0 232  TYR A CD1 1 ? 
ATOM   1668 C CD2 . TYR A 1 228 ? 24.012  -59.170 6.440   1.000 14.202 0 232  TYR A CD2 1 ? 
ATOM   1669 C CE1 . TYR A 1 228 ? 24.024  -57.843 8.878   1.000 16.918 0 232  TYR A CE1 1 ? 
ATOM   1670 C CE2 . TYR A 1 228 ? 25.129  -59.234 7.264   1.000 15.920 0 232  TYR A CE2 1 ? 
ATOM   1671 C CZ  . TYR A 1 228 ? 25.128  -58.577 8.479   1.000 19.373 0 232  TYR A CZ  1 ? 
ATOM   1672 O OH  . TYR A 1 228 ? 26.256  -58.649 9.281   1.000 18.305 0 232  TYR A OH  1 ? 
ATOM   1673 N N   . GLY A 1 229 ? 22.209  -55.585 3.408   1.000 17.839 0 233  GLY A N   1 ? 
ATOM   1674 C CA  . GLY A 1 229 ? 23.178  -55.001 2.502   1.000 16.702 0 233  GLY A CA  1 ? 
ATOM   1675 C C   . GLY A 1 229 ? 24.110  -54.068 3.248   1.000 17.863 0 233  GLY A C   1 ? 
ATOM   1676 O O   . GLY A 1 229 ? 24.348  -54.216 4.451   1.000 17.455 0 233  GLY A O   1 ? 
ATOM   1677 N N   . ASP A 1 230 ? 24.644  -53.076 2.542   1.000 17.710 0 234  ASP A N   1 ? 
ATOM   1678 C CA  . ASP A 1 230 ? 25.645  -52.236 3.194   1.000 19.100 0 234  ASP A CA  1 ? 
ATOM   1679 C C   . ASP A 1 230 ? 25.046  -51.459 4.363   1.000 19.837 0 234  ASP A C   1 ? 
ATOM   1680 O O   . ASP A 1 230 ? 25.655  -51.367 5.440   1.000 17.884 0 234  ASP A O   1 ? 
ATOM   1681 C CB  . ASP A 1 230 ? 26.280  -51.305 2.169   1.000 20.429 0 234  ASP A CB  1 ? 
ATOM   1682 C CG  . ASP A 1 230 ? 27.144  -52.064 1.185   1.000 23.990 0 234  ASP A CG  1 ? 
ATOM   1683 O OD1 . ASP A 1 230 ? 27.745  -53.079 1.606   1.000 25.024 0 234  ASP A OD1 1 ? 
ATOM   1684 O OD2 . ASP A 1 230 ? 27.207  -51.664 0.006   1.000 24.063 0 234  ASP A OD2 1 ? 
ATOM   1685 N N   . VAL A 1 231 ? 23.839  -50.915 4.189   1.000 16.444 0 235  VAL A N   1 ? 
ATOM   1686 C CA  . VAL A 1 231 ? 23.215  -50.161 5.270   1.000 16.499 0 235  VAL A CA  1 ? 
ATOM   1687 C C   . VAL A 1 231 ? 22.843  -51.085 6.426   1.000 17.834 0 235  VAL A C   1 ? 
ATOM   1688 O O   . VAL A 1 231 ? 23.145  -50.799 7.591   1.000 17.749 0 235  VAL A O   1 ? 
ATOM   1689 C CB  . VAL A 1 231 ? 21.982  -49.407 4.739   1.000 16.207 0 235  VAL A CB  1 ? 
ATOM   1690 C CG1 . VAL A 1 231 ? 21.159  -48.814 5.885   1.000 18.223 0 235  VAL A CG1 1 ? 
ATOM   1691 C CG2 . VAL A 1 231 ? 22.418  -48.315 3.758   1.000 18.392 0 235  VAL A CG2 1 ? 
ATOM   1692 N N   . GLY A 1 232 ? 22.150  -52.194 6.126   1.000 15.989 0 236  GLY A N   1 ? 
ATOM   1693 C CA  . GLY A 1 232 ? 21.736  -53.104 7.190   1.000 15.447 0 236  GLY A CA  1 ? 
ATOM   1694 C C   . GLY A 1 232 ? 22.911  -53.673 7.968   1.000 16.739 0 236  GLY A C   1 ? 
ATOM   1695 O O   . GLY A 1 232 ? 22.822  -53.876 9.182   1.000 16.439 0 236  GLY A O   1 ? 
ATOM   1696 N N   . LYS A 1 233 ? 24.023  -53.948 7.276   1.000 16.886 0 237  LYS A N   1 ? 
ATOM   1697 C CA  . LYS A 1 233 ? 25.215  -54.433 7.969   1.000 15.686 0 237  LYS A CA  1 ? 
ATOM   1698 C C   . LYS A 1 233 ? 25.689  -53.417 8.998   1.000 16.936 0 237  LYS A C   1 ? 
ATOM   1699 O O   . LYS A 1 233 ? 26.056  -53.784 10.123  1.000 17.771 0 237  LYS A O   1 ? 
ATOM   1700 C CB  . LYS A 1 233 ? 26.336  -54.719 6.962   1.000 16.094 0 237  LYS A CB  1 ? 
ATOM   1701 C CG  . LYS A 1 233 ? 26.201  -56.034 6.185   1.000 16.881 0 237  LYS A CG  1 ? 
ATOM   1702 C CD  . LYS A 1 233 ? 27.280  -56.100 5.081   1.000 15.802 0 237  LYS A CD  1 ? 
ATOM   1703 C CE  . LYS A 1 233 ? 27.308  -57.481 4.419   1.000 17.305 0 237  LYS A CE  1 ? 
ATOM   1704 N NZ  . LYS A 1 233 ? 26.163  -57.676 3.418   1.000 17.157 0 237  LYS A NZ  1 ? 
ATOM   1705 N N   . GLY A 1 234 ? 25.699  -52.133 8.624   1.000 15.115 0 238  GLY A N   1 ? 
ATOM   1706 C CA  . GLY A 1 234 ? 26.135  -51.111 9.564   1.000 16.428 0 238  GLY A CA  1 ? 
ATOM   1707 C C   . GLY A 1 234 ? 25.160  -50.954 10.715  1.000 17.802 0 238  GLY A C   1 ? 
ATOM   1708 O O   . GLY A 1 234 ? 25.567  -50.790 11.868  1.000 17.384 0 238  GLY A O   1 ? 
ATOM   1709 N N   . CYS A 1 235 ? 23.856  -51.004 10.417  1.000 16.284 0 239  CYS A N   1 ? 
ATOM   1710 C CA  . CYS A 1 235 ? 22.847  -50.905 11.468  1.000 17.076 0 239  CYS A CA  1 ? 
ATOM   1711 C C   . CYS A 1 235 ? 22.972  -52.055 12.464  1.000 18.157 0 239  CYS A C   1 ? 
ATOM   1712 O O   . CYS A 1 235 ? 22.834  -51.857 13.676  1.000 17.526 0 239  CYS A O   1 ? 
ATOM   1713 C CB  . CYS A 1 235 ? 21.449  -50.912 10.848  1.000 18.389 0 239  CYS A CB  1 ? 
ATOM   1714 S SG  . CYS A 1 235 ? 21.088  -49.422 9.860   1.000 19.534 0 239  CYS A SG  1 ? 
ATOM   1715 N N   . ALA A 1 236 ? 23.201  -53.273 11.963  1.000 18.123 0 240  ALA A N   1 ? 
ATOM   1716 C CA  . ALA A 1 236 ? 23.294  -54.426 12.851  1.000 20.602 0 240  ALA A CA  1 ? 
ATOM   1717 C C   . ALA A 1 236 ? 24.490  -54.294 13.782  1.000 19.610 0 240  ALA A C   1 ? 
ATOM   1718 O O   . ALA A 1 236 ? 24.376  -54.528 14.990  1.000 21.324 0 240  ALA A O   1 ? 
ATOM   1719 C CB  . ALA A 1 236 ? 23.391  -55.721 12.037  1.000 19.892 0 240  ALA A CB  1 ? 
ATOM   1720 N N   . GLN A 1 237 ? 25.645  -53.892 13.242  1.000 18.747 0 241  GLN A N   1 ? 
ATOM   1721 C CA  . GLN A 1 237 ? 26.816  -53.722 14.093  1.000 19.097 0 241  GLN A CA  1 ? 
ATOM   1722 C C   . GLN A 1 237 ? 26.554  -52.662 15.160  1.000 22.224 0 241  GLN A C   1 ? 
ATOM   1723 O O   . GLN A 1 237 ? 26.916  -52.846 16.331  1.000 22.919 0 241  GLN A O   1 ? 
ATOM   1724 C CB  . GLN A 1 237 ? 28.038  -53.362 13.244  1.000 25.224 0 241  GLN A CB  1 ? 
ATOM   1725 C CG  . GLN A 1 237 ? 29.333  -53.869 13.865  1.000 34.159 0 241  GLN A CG  1 ? 
ATOM   1726 C CD  . GLN A 1 237 ? 30.571  -53.537 13.047  1.000 37.441 0 241  GLN A CD  1 ? 
ATOM   1727 O OE1 . GLN A 1 237 ? 30.492  -52.858 12.036  1.000 30.335 0 241  GLN A OE1 1 ? 
ATOM   1728 N NE2 . GLN A 1 237 ? 31.723  -54.034 13.488  1.000 51.577 0 241  GLN A NE2 1 ? 
ATOM   1729 N N   . ALA A 1 238 ? 25.881  -51.573 14.776  1.000 17.434 0 242  ALA A N   1 ? 
ATOM   1730 C CA  . ALA A 1 238 ? 25.578  -50.486 15.708  1.000 17.718 0 242  ALA A CA  1 ? 
ATOM   1731 C C   . ALA A 1 238 ? 24.782  -50.994 16.898  1.000 19.531 0 242  ALA A C   1 ? 
ATOM   1732 O O   . ALA A 1 238 ? 25.151  -50.762 18.056  1.000 19.939 0 242  ALA A O   1 ? 
ATOM   1733 C CB  . ALA A 1 238 ? 24.797  -49.380 15.002  1.000 19.529 0 242  ALA A CB  1 ? 
ATOM   1734 N N   . LEU A 1 239 ? 23.677  -51.694 16.627  1.000 16.205 0 243  LEU A N   1 ? 
ATOM   1735 C CA  . LEU A 1 239 ? 22.797  -52.092 17.717  1.000 15.457 0 243  LEU A CA  1 ? 
ATOM   1736 C C   . LEU A 1 239 ? 23.413  -53.224 18.536  1.000 16.428 0 243  LEU A C   1 ? 
ATOM   1737 O O   . LEU A 1 239 ? 23.238  -53.284 19.760  1.000 18.013 0 243  LEU A O   1 ? 
ATOM   1738 C CB  . LEU A 1 239 ? 21.432  -52.502 17.157  1.000 17.292 0 243  LEU A CB  1 ? 
ATOM   1739 C CG  . LEU A 1 239 ? 20.722  -51.400 16.367  1.000 19.894 0 243  LEU A CG  1 ? 
ATOM   1740 C CD1 . LEU A 1 239 ? 19.341  -51.865 15.894  1.000 19.513 0 243  LEU A CD1 1 ? 
ATOM   1741 C CD2 . LEU A 1 239 ? 20.580  -50.149 17.216  1.000 23.887 0 243  LEU A CD2 1 ? 
ATOM   1742 N N   . ARG A 1 240 ? 24.115  -54.144 17.872  1.000 18.750 0 244  ARG A N   1 ? 
ATOM   1743 C CA  . ARG A 1 240 ? 24.729  -55.255 18.593  1.000 24.332 0 244  ARG A CA  1 ? 
ATOM   1744 C C   . ARG A 1 240 ? 25.768  -54.740 19.580  1.000 21.845 0 244  ARG A C   1 ? 
ATOM   1745 O O   . ARG A 1 240 ? 25.848  -55.219 20.721  1.000 23.305 0 244  ARG A O   1 ? 
ATOM   1746 C CB  . ARG A 1 240 ? 25.342  -56.238 17.592  1.000 28.880 0 244  ARG A CB  1 ? 
ATOM   1747 C CG  . ARG A 1 240 ? 26.180  -57.372 18.188  1.000 37.068 0 244  ARG A CG  1 ? 
ATOM   1748 C CD  . ARG A 1 240 ? 27.528  -57.428 17.472  1.000 44.963 0 244  ARG A CD  1 ? 
ATOM   1749 N NE  . ARG A 1 240 ? 28.388  -58.527 17.917  1.000 46.032 0 244  ARG A NE  1 ? 
ATOM   1750 C CZ  . ARG A 1 240 ? 28.736  -59.554 17.150  1.000 46.698 0 244  ARG A CZ  1 ? 
ATOM   1751 N NH1 . ARG A 1 240 ? 28.289  -59.630 15.900  1.000 42.105 0 244  ARG A NH1 1 ? 
ATOM   1752 N NH2 . ARG A 1 240 ? 29.529  -60.505 17.628  1.000 46.916 0 244  ARG A NH2 1 ? 
ATOM   1753 N N   . GLY A 1 241 ? 26.525  -53.722 19.177  1.000 19.429 0 245  GLY A N   1 ? 
ATOM   1754 C CA  . GLY A 1 241 ? 27.542  -53.158 20.048  1.000 23.966 0 245  GLY A CA  1 ? 
ATOM   1755 C C   . GLY A 1 241 ? 26.954  -52.493 21.273  1.000 26.077 0 245  GLY A C   1 ? 
ATOM   1756 O O   . GLY A 1 241 ? 27.608  -52.422 22.318  1.000 28.267 0 245  GLY A O   1 ? 
ATOM   1757 N N   . GLN A 1 242 ? 25.722  -52.006 21.170  1.000 16.923 0 246  GLN A N   1 ? 
ATOM   1758 C CA  . GLN A 1 242 ? 25.039  -51.350 22.276  1.000 16.334 0 246  GLN A CA  1 ? 
ATOM   1759 C C   . GLN A 1 242 ? 24.209  -52.322 23.118  1.000 17.805 0 246  GLN A C   1 ? 
ATOM   1760 O O   . GLN A 1 242 ? 23.462  -51.877 23.994  1.000 21.732 0 246  GLN A O   1 ? 
ATOM   1761 C CB  . GLN A 1 242 ? 24.154  -50.215 21.742  1.000 20.092 0 246  GLN A CB  1 ? 
ATOM   1762 C CG  . GLN A 1 242 ? 24.959  -49.120 21.020  1.000 20.381 0 246  GLN A CG  1 ? 
ATOM   1763 C CD  . GLN A 1 242 ? 25.377  -48.006 21.955  1.000 24.190 0 246  GLN A CD  1 ? 
ATOM   1764 O OE1 . GLN A 1 242 ? 24.627  -47.058 22.167  1.000 27.140 0 246  GLN A OE1 1 ? 
ATOM   1765 N NE2 . GLN A 1 242 ? 26.579  -48.112 22.515  1.000 22.000 0 246  GLN A NE2 1 ? 
ATOM   1766 N N   . GLY A 1 243 ? 24.311  -53.624 22.869  1.000 18.450 0 247  GLY A N   1 ? 
ATOM   1767 C CA  . GLY A 1 243 ? 23.672  -54.611 23.726  1.000 16.655 0 247  GLY A CA  1 ? 
ATOM   1768 C C   . GLY A 1 243 ? 22.312  -55.109 23.288  1.000 17.634 0 247  GLY A C   1 ? 
ATOM   1769 O O   . GLY A 1 243 ? 21.642  -55.787 24.072  1.000 16.947 0 247  GLY A O   1 ? 
ATOM   1770 N N   . ALA A 1 244 ? 21.874  -54.797 22.074  1.000 18.297 0 248  ALA A N   1 ? 
ATOM   1771 C CA  . ALA A 1 244 ? 20.623  -55.375 21.601  1.000 17.542 0 248  ALA A CA  1 ? 
ATOM   1772 C C   . ALA A 1 244 ? 20.830  -56.803 21.109  1.000 16.370 0 248  ALA A C   1 ? 
ATOM   1773 O O   . ALA A 1 244 ? 21.909  -57.168 20.629  1.000 17.652 0 248  ALA A O   1 ? 
ATOM   1774 C CB  . ALA A 1 244 ? 20.032  -54.530 20.470  1.000 18.658 0 248  ALA A CB  1 ? 
ATOM   1775 N N   . THR A 1 245 ? 19.775  -57.615 21.231  1.000 15.744 0 249  THR A N   1 ? 
ATOM   1776 C CA  . THR A 1 245 ? 19.677  -58.843 20.455  1.000 16.168 0 249  THR A CA  1 ? 
ATOM   1777 C C   . THR A 1 245 ? 19.220  -58.455 19.059  1.000 17.281 0 249  THR A C   1 ? 
ATOM   1778 O O   . THR A 1 245 ? 18.142  -57.870 18.914  1.000 19.966 0 249  THR A O   1 ? 
ATOM   1779 C CB  . THR A 1 245 ? 18.671  -59.793 21.094  1.000 20.850 0 249  THR A CB  1 ? 
ATOM   1780 O OG1 . THR A 1 245 ? 19.094  -60.092 22.428  1.000 21.492 0 249  THR A OG1 1 ? 
ATOM   1781 C CG2 . THR A 1 245 ? 18.567  -61.067 20.268  1.000 22.374 0 249  THR A CG2 1 ? 
ATOM   1782 N N   . VAL A 1 246 ? 20.030  -58.748 18.043  1.000 15.636 0 250  VAL A N   1 ? 
ATOM   1783 C CA  . VAL A 1 246 ? 19.770  -58.278 16.685  1.000 15.923 0 250  VAL A CA  1 ? 
ATOM   1784 C C   . VAL A 1 246 ? 19.268  -59.437 15.843  1.000 18.213 0 250  VAL A C   1 ? 
ATOM   1785 O O   . VAL A 1 246 ? 19.944  -60.467 15.726  1.000 17.718 0 250  VAL A O   1 ? 
ATOM   1786 C CB  . VAL A 1 246 ? 21.016  -57.657 16.045  1.000 16.034 0 250  VAL A CB  1 ? 
ATOM   1787 C CG1 . VAL A 1 246 ? 20.709  -57.314 14.587  1.000 18.668 0 250  VAL A CG1 1 ? 
ATOM   1788 C CG2 . VAL A 1 246 ? 21.430  -56.411 16.820  1.000 18.810 0 250  VAL A CG2 1 ? 
ATOM   1789 N N   . LEU A 1 247 ? 18.082  -59.260 15.266  1.000 16.370 0 251  LEU A N   1 ? 
ATOM   1790 C CA  . LEU A 1 247 ? 17.499  -60.157 14.278  1.000 16.673 0 251  LEU A CA  1 ? 
ATOM   1791 C C   . LEU A 1 247 ? 17.626  -59.519 12.904  1.000 17.236 0 251  LEU A C   1 ? 
ATOM   1792 O O   . LEU A 1 247 ? 17.571  -58.295 12.772  1.000 19.205 0 251  LEU A O   1 ? 
ATOM   1793 C CB  . LEU A 1 247 ? 16.013  -60.405 14.578  1.000 16.160 0 251  LEU A CB  1 ? 
ATOM   1794 C CG  . LEU A 1 247 ? 15.658  -60.871 15.982  1.000 17.460 0 251  LEU A CG  1 ? 
ATOM   1795 C CD1 . LEU A 1 247 ? 14.118  -60.970 16.133  1.000 19.684 0 251  LEU A CD1 1 ? 
ATOM   1796 C CD2 . LEU A 1 247 ? 16.315  -62.206 16.237  1.000 23.163 0 251  LEU A CD2 1 ? 
ATOM   1797 N N   . VAL A 1 248 ? 17.756  -60.353 11.872  1.000 17.031 0 252  VAL A N   1 ? 
ATOM   1798 C CA  . VAL A 1 248 ? 17.923  -59.868 10.504  1.000 15.054 0 252  VAL A CA  1 ? 
ATOM   1799 C C   . VAL A 1 248 ? 16.942  -60.595 9.593   1.000 16.634 0 252  VAL A C   1 ? 
ATOM   1800 O O   . VAL A 1 248 ? 16.794  -61.814 9.686   1.000 18.076 0 252  VAL A O   1 ? 
ATOM   1801 C CB  . VAL A 1 248 ? 19.368  -60.082 10.005  1.000 17.284 0 252  VAL A CB  1 ? 
ATOM   1802 C CG1 . VAL A 1 248 ? 19.481  -59.774 8.510   1.000 19.413 0 252  VAL A CG1 1 ? 
ATOM   1803 C CG2 . VAL A 1 248 ? 20.351  -59.201 10.790  1.000 17.876 0 252  VAL A CG2 1 ? 
ATOM   1804 N N   . ALA A 1 249 ? 16.274  -59.854 8.707   1.000 18.271 0 253  ALA A N   1 ? 
ATOM   1805 C CA  . ALA A 1 249 ? 15.493  -60.456 7.630   1.000 16.699 0 253  ALA A CA  1 ? 
ATOM   1806 C C   . ALA A 1 249 ? 16.190  -60.217 6.298   1.000 17.376 0 253  ALA A C   1 ? 
ATOM   1807 O O   . ALA A 1 249 ? 16.738  -59.135 6.068   1.000 17.623 0 253  ALA A O   1 ? 
ATOM   1808 C CB  . ALA A 1 249 ? 14.078  -59.877 7.575   1.000 19.347 0 253  ALA A CB  1 ? 
ATOM   1809 N N   . GLU A 1 250 ? 16.143  -61.217 5.413   1.000 18.389 0 254  GLU A N   1 ? 
ATOM   1810 C CA  . GLU A 1 250 ? 16.771  -61.079 4.105   1.000 16.586 0 254  GLU A CA  1 ? 
ATOM   1811 C C   . GLU A 1 250 ? 16.026  -61.906 3.068   1.000 17.194 0 254  GLU A C   1 ? 
ATOM   1812 O O   . GLU A 1 250 ? 15.483  -62.968 3.377   1.000 19.508 0 254  GLU A O   1 ? 
ATOM   1813 C CB  . GLU A 1 250 ? 18.246  -61.527 4.113   1.000 16.615 0 254  GLU A CB  1 ? 
ATOM   1814 C CG  . GLU A 1 250 ? 19.245  -60.367 4.077   1.000 17.144 0 254  GLU A CG  1 ? 
ATOM   1815 C CD  . GLU A 1 250 ? 19.231  -59.577 2.769   1.000 18.294 0 254  GLU A CD  1 ? 
ATOM   1816 O OE1 . GLU A 1 250 ? 19.860  -58.490 2.734   1.000 16.557 0 254  GLU A OE1 1 ? 
ATOM   1817 O OE2 . GLU A 1 250 ? 18.607  -60.030 1.784   1.000 17.768 0 254  GLU A OE2 1 ? 
ATOM   1818 N N   . ILE A 1 251 ? 16.029  -61.416 1.826   1.000 18.329 0 255  ILE A N   1 ? 
ATOM   1819 C CA  . ILE A 1 251 ? 15.570  -62.201 0.682   1.000 16.868 0 255  ILE A CA  1 ? 
ATOM   1820 C C   . ILE A 1 251 ? 16.739  -62.823 -0.073  1.000 17.215 0 255  ILE A C   1 ? 
ATOM   1821 O O   . ILE A 1 251 ? 16.521  -63.728 -0.896  1.000 19.666 0 255  ILE A O   1 ? 
ATOM   1822 C CB  . ILE A 1 251 ? 14.715  -61.351 -0.289  1.000 17.597 0 255  ILE A CB  1 ? 
ATOM   1823 C CG1 . ILE A 1 251 ? 15.507  -60.149 -0.821  1.000 19.292 0 255  ILE A CG1 1 ? 
ATOM   1824 C CG2 . ILE A 1 251 ? 13.438  -60.873 0.389   1.000 19.689 0 255  ILE A CG2 1 ? 
ATOM   1825 C CD1 . ILE A 1 251 ? 16.105  -60.355 -2.194  1.000 20.213 0 255  ILE A CD1 1 ? 
ATOM   1826 N N   . ASP A 1 252 ? 17.962  -62.359 0.170   1.000 17.220 0 256  ASP A N   1 ? 
ATOM   1827 C CA  . ASP A 1 252 ? 19.127  -62.787 -0.589  1.000 18.747 0 256  ASP A CA  1 ? 
ATOM   1828 C C   . ASP A 1 252 ? 19.864  -63.830 0.223   1.000 17.002 0 256  ASP A C   1 ? 
ATOM   1829 O O   . ASP A 1 252 ? 20.290  -63.528 1.352   1.000 17.605 0 256  ASP A O   1 ? 
ATOM   1830 C CB  . ASP A 1 252 ? 20.020  -61.588 -0.878  1.000 16.984 0 256  ASP A CB  1 ? 
ATOM   1831 C CG  . ASP A 1 252 ? 21.248  -61.939 -1.711  1.000 20.774 0 256  ASP A CG  1 ? 
ATOM   1832 O OD1 . ASP A 1 252 ? 21.828  -63.026 -1.520  1.000 22.971 0 256  ASP A OD1 1 ? 
ATOM   1833 O OD2 . ASP A 1 252 ? 21.632  -61.113 -2.558  1.000 20.487 0 256  ASP A OD2 1 ? 
ATOM   1834 N N   . PRO A 1 253 ? 20.021  -65.059 -0.280  1.000 17.826 0 257  PRO A N   1 ? 
ATOM   1835 C CA  . PRO A 1 253 ? 20.624  -66.111 0.552   1.000 17.571 0 257  PRO A CA  1 ? 
ATOM   1836 C C   . PRO A 1 253 ? 22.083  -65.837 0.893   1.000 18.476 0 257  PRO A C   1 ? 
ATOM   1837 O O   . PRO A 1 253 ? 22.558  -66.307 1.933   1.000 18.334 0 257  PRO A O   1 ? 
ATOM   1838 C CB  . PRO A 1 253 ? 20.484  -67.374 -0.309  1.000 20.060 0 257  PRO A CB  1 ? 
ATOM   1839 C CG  . PRO A 1 253 ? 20.380  -66.859 -1.726  1.000 22.747 0 257  PRO A CG  1 ? 
ATOM   1840 C CD  . PRO A 1 253 ? 19.645  -65.544 -1.622  1.000 18.750 0 257  PRO A CD  1 ? 
ATOM   1841 N N   . ILE A 1 254 ? 22.817  -65.116 0.043   1.000 17.010 0 258  ILE A N   1 ? 
ATOM   1842 C CA  . ILE A 1 254 ? 24.212  -64.815 0.372   1.000 14.568 0 258  ILE A CA  1 ? 
ATOM   1843 C C   . ILE A 1 254 ? 24.274  -63.822 1.525   1.000 17.681 0 258  ILE A C   1 ? 
ATOM   1844 O O   . ILE A 1 254 ? 25.008  -64.019 2.501   1.000 17.313 0 258  ILE A O   1 ? 
ATOM   1845 C CB  . ILE A 1 254 ? 24.967  -64.286 -0.862  1.000 16.465 0 258  ILE A CB  1 ? 
ATOM   1846 C CG1 . ILE A 1 254 ? 24.995  -65.346 -1.974  1.000 17.552 0 258  ILE A CG1 1 ? 
ATOM   1847 C CG2 . ILE A 1 254 ? 26.413  -63.865 -0.475  1.000 17.407 0 258  ILE A CG2 1 ? 
ATOM   1848 C CD1 . ILE A 1 254 ? 25.524  -64.823 -3.297  1.000 20.516 0 258  ILE A CD1 1 ? 
ATOM   1849 N N   . CYS A 1 255 ? 23.476  -62.751 1.450   1.000 18.447 0 259  CYS A N   1 ? 
ATOM   1850 C CA  . CYS A 1 255 ? 23.449  -61.797 2.558   1.000 15.244 0 259  CYS A CA  1 ? 
ATOM   1851 C C   . CYS A 1 255 ? 22.910  -62.437 3.831   1.000 18.036 0 259  CYS A C   1 ? 
ATOM   1852 O O   . CYS A 1 255 ? 23.390  -62.140 4.929   1.000 17.805 0 259  CYS A O   1 ? 
ATOM   1853 C CB  . CYS A 1 255 ? 22.612  -60.579 2.181   1.000 17.231 0 259  CYS A CB  1 ? 
ATOM   1854 S SG  . CYS A 1 255 ? 23.313  -59.675 0.776   1.000 19.852 0 259  CYS A SG  1 ? 
ATOM   1855 N N   . ALA A 1 256 ? 21.895  -63.300 3.710   1.000 16.452 0 260  ALA A N   1 ? 
ATOM   1856 C CA  . ALA A 1 256 ? 21.405  -64.018 4.887   1.000 16.668 0 260  ALA A CA  1 ? 
ATOM   1857 C C   . ALA A 1 256 ? 22.514  -64.849 5.523   1.000 18.389 0 260  ALA A C   1 ? 
ATOM   1858 O O   . ALA A 1 256 ? 22.648  -64.889 6.756   1.000 16.881 0 260  ALA A O   1 ? 
ATOM   1859 C CB  . ALA A 1 256 ? 20.218  -64.921 4.513   1.000 17.486 0 260  ALA A CB  1 ? 
ATOM   1860 N N   . LEU A 1 257 ? 23.301  -65.542 4.700   1.000 17.099 0 261  LEU A N   1 ? 
ATOM   1861 C CA  . LEU A 1 257 ? 24.377  -66.366 5.242   1.000 17.047 0 261  LEU A CA  1 ? 
ATOM   1862 C C   . LEU A 1 257 ? 25.437  -65.506 5.922   1.000 17.771 0 261  LEU A C   1 ? 
ATOM   1863 O O   . LEU A 1 257 ? 25.969  -65.885 6.969   1.000 17.665 0 261  LEU A O   1 ? 
ATOM   1864 C CB  . LEU A 1 257 ? 24.993  -67.225 4.133   1.000 19.105 0 261  LEU A CB  1 ? 
ATOM   1865 C CG  . LEU A 1 257 ? 25.933  -68.336 4.630   1.000 19.252 0 261  LEU A CG  1 ? 
ATOM   1866 C CD1 . LEU A 1 257 ? 25.198  -69.351 5.489   1.000 21.832 0 261  LEU A CD1 1 ? 
ATOM   1867 C CD2 . LEU A 1 257 ? 26.589  -69.044 3.466   1.000 22.308 0 261  LEU A CD2 1 ? 
ATOM   1868 N N   . GLN A 1 258 ? 25.732  -64.327 5.365   1.000 16.052 0 262  GLN A N   1 ? 
ATOM   1869 C CA  . GLN A 1 258 ? 26.633  -63.398 6.046   1.000 16.341 0 262  GLN A CA  1 ? 
ATOM   1870 C C   . GLN A 1 258 ? 26.110  -63.047 7.431   1.000 18.863 0 262  GLN A C   1 ? 
ATOM   1871 O O   . GLN A 1 258 ? 26.851  -63.077 8.420   1.000 17.202 0 262  GLN A O   1 ? 
ATOM   1872 C CB  . GLN A 1 258 ? 26.786  -62.119 5.223   1.000 16.144 0 262  GLN A CB  1 ? 
ATOM   1873 C CG  . GLN A 1 258 ? 27.600  -62.279 3.947   1.000 15.583 0 262  GLN A CG  1 ? 
ATOM   1874 C CD  . GLN A 1 258 ? 27.723  -60.973 3.197   1.000 17.776 0 262  GLN A CD  1 ? 
ATOM   1875 O OE1 . GLN A 1 258 ? 26.718  -60.365 2.834   1.000 17.694 0 262  GLN A OE1 1 ? 
ATOM   1876 N NE2 . GLN A 1 258 ? 28.958  -60.520 2.972   1.000 16.757 0 262  GLN A NE2 1 ? 
ATOM   1877 N N   . ALA A 1 259 ? 24.831  -62.675 7.517   1.000 15.615 0 263  ALA A N   1 ? 
ATOM   1878 C CA  . ALA A 1 259 ? 24.282  -62.293 8.815   1.000 15.807 0 263  ALA A CA  1 ? 
ATOM   1879 C C   . ALA A 1 259 ? 24.368  -63.446 9.807   1.000 15.610 0 263  ALA A C   1 ? 
ATOM   1880 O O   . ALA A 1 259 ? 24.695  -63.249 10.983  1.000 17.005 0 263  ALA A O   1 ? 
ATOM   1881 C CB  . ALA A 1 259 ? 22.825  -61.834 8.644   1.000 15.981 0 263  ALA A CB  1 ? 
ATOM   1882 N N   . ALA A 1 260 ? 24.057  -64.660 9.357   1.000 16.718 0 264  ALA A N   1 ? 
ATOM   1883 C CA  . ALA A 1 260 ? 24.104  -65.805 10.258  1.000 17.505 0 264  ALA A CA  1 ? 
ATOM   1884 C C   . ALA A 1 260 ? 25.514  -66.046 10.766  1.000 19.934 0 264  ALA A C   1 ? 
ATOM   1885 O O   . ALA A 1 260 ? 25.716  -66.392 11.938  1.000 22.032 0 264  ALA A O   1 ? 
ATOM   1886 C CB  . ALA A 1 260 ? 23.584  -67.044 9.540   1.000 18.400 0 264  ALA A CB  1 ? 
ATOM   1887 N N   . MET A 1 261 ? 26.507  -65.853 9.900   1.000 17.397 0 265  MET A N   1 ? 
ATOM   1888 C CA  . MET A 1 261 ? 27.885  -66.078 10.298  1.000 19.273 0 265  MET A CA  1 ? 
ATOM   1889 C C   . MET A 1 261 ? 28.419  -64.987 11.219  1.000 18.805 0 265  MET A C   1 ? 
ATOM   1890 O O   . MET A 1 261 ? 29.503  -65.160 11.788  1.000 19.226 0 265  MET A O   1 ? 
ATOM   1891 C CB  . MET A 1 261 ? 28.759  -66.213 9.047   1.000 21.753 0 265  MET A CB  1 ? 
ATOM   1892 C CG  . MET A 1 261 ? 28.377  -67.389 8.188   1.000 28.369 0 265  MET A CG  1 ? 
ATOM   1893 S SD  . MET A 1 261 ? 28.776  -68.945 8.988   1.000 31.343 0 265  MET A SD  1 ? 
ATOM   1894 C CE  . MET A 1 261 ? 30.531  -69.083 8.629   1.000 31.543 0 265  MET A CE  1 ? 
ATOM   1895 N N   . GLU A 1 262 ? 27.701  -63.870 11.377  1.000 16.936 0 266  GLU A N   1 ? 
ATOM   1896 C CA  . GLU A 1 262 ? 28.034  -62.878 12.390  1.000 16.784 0 266  GLU A CA  1 ? 
ATOM   1897 C C   . GLU A 1 262 ? 27.249  -63.081 13.676  1.000 21.074 0 266  GLU A C   1 ? 
ATOM   1898 O O   . GLU A 1 262 ? 27.352  -62.251 14.586  1.000 27.201 0 266  GLU A O   1 ? 
ATOM   1899 C CB  . GLU A 1 262 ? 27.782  -61.456 11.871  1.000 21.255 0 266  GLU A CB  1 ? 
ATOM   1900 C CG  . GLU A 1 262 ? 28.328  -61.176 10.487  1.000 27.116 0 266  GLU A CG  1 ? 
ATOM   1901 C CD  . GLU A 1 262 ? 29.840  -61.013 10.442  1.000 36.486 0 266  GLU A CD  1 ? 
ATOM   1902 O OE1 . GLU A 1 262 ? 30.523  -61.228 11.483  1.000 28.890 0 266  GLU A OE1 1 ? 
ATOM   1903 O OE2 . GLU A 1 262 ? 30.338  -60.650 9.346   1.000 36.902 0 266  GLU A OE2 1 ? 
ATOM   1904 N N   . GLY A 1 263 ? 26.454  -64.141 13.755  1.000 17.884 0 267  GLY A N   1 ? 
ATOM   1905 C CA  . GLY A 1 263 ? 25.732  -64.501 14.958  1.000 21.363 0 267  GLY A CA  1 ? 
ATOM   1906 C C   . GLY A 1 263 ? 24.309  -63.997 15.037  1.000 22.503 0 267  GLY A C   1 ? 
ATOM   1907 O O   . GLY A 1 263 ? 23.663  -64.198 16.071  1.000 25.108 0 267  GLY A O   1 ? 
ATOM   1908 N N   . TYR A 1 264 ? 23.795  -63.362 13.990  1.000 17.499 0 268  TYR A N   1 ? 
ATOM   1909 C CA  . TYR A 1 264 ? 22.407  -62.901 13.997  1.000 16.462 0 268  TYR A CA  1 ? 
ATOM   1910 C C   . TYR A 1 264 ? 21.475  -64.012 13.550  1.000 19.592 0 268  TYR A C   1 ? 
ATOM   1911 O O   . TYR A 1 264 ? 21.737  -64.705 12.559  1.000 20.110 0 268  TYR A O   1 ? 
ATOM   1912 C CB  . TYR A 1 264 ? 22.213  -61.689 13.076  1.000 14.899 0 268  TYR A CB  1 ? 
ATOM   1913 C CG  . TYR A 1 264 ? 23.210  -60.607 13.368  1.000 15.823 0 268  TYR A CG  1 ? 
ATOM   1914 C CD1 . TYR A 1 264 ? 23.294  -60.068 14.635  1.000 18.650 0 268  TYR A CD1 1 ? 
ATOM   1915 C CD2 . TYR A 1 264 ? 24.071  -60.146 12.388  1.000 16.781 0 268  TYR A CD2 1 ? 
ATOM   1916 C CE1 . TYR A 1 264 ? 24.225  -59.088 14.934  1.000 21.800 0 268  TYR A CE1 1 ? 
ATOM   1917 C CE2 . TYR A 1 264 ? 25.011  -59.155 12.666  1.000 17.950 0 268  TYR A CE2 1 ? 
ATOM   1918 C CZ  . TYR A 1 264 ? 25.077  -58.637 13.946  1.000 22.255 0 268  TYR A CZ  1 ? 
ATOM   1919 O OH  . TYR A 1 264 ? 26.005  -57.652 14.235  1.000 25.748 0 268  TYR A OH  1 ? 
ATOM   1920 N N   . ARG A 1 265 ? 20.367  -64.163 14.267  1.000 15.639 0 269  ARG A N   1 ? 
ATOM   1921 C CA  . ARG A 1 265 ? 19.338  -65.071 13.788  1.000 15.978 0 269  ARG A CA  1 ? 
ATOM   1922 C C   . ARG A 1 265 ? 18.628  -64.427 12.612  1.000 20.231 0 269  ARG A C   1 ? 
ATOM   1923 O O   . ARG A 1 265 ? 18.266  -63.250 12.671  1.000 20.658 0 269  ARG A O   1 ? 
ATOM   1924 C CB  . ARG A 1 265 ? 18.341  -65.394 14.903  1.000 21.050 0 269  ARG A CB  1 ? 
ATOM   1925 C CG  . ARG A 1 265 ? 18.955  -66.152 16.074  1.000 20.331 0 269  ARG A CG  1 ? 
ATOM   1926 C CD  . ARG A 1 265 ? 19.210  -67.617 15.741  1.000 24.721 0 269  ARG A CD  1 ? 
ATOM   1927 N NE  . ARG A 1 265 ? 20.576  -67.827 15.291  1.000 26.185 0 269  ARG A NE  1 ? 
ATOM   1928 C CZ  . ARG A 1 265 ? 20.992  -68.892 14.605  1.000 32.786 0 269  ARG A CZ  1 ? 
ATOM   1929 N NH1 . ARG A 1 265 ? 20.131  -69.863 14.285  1.000 27.403 0 269  ARG A NH1 1 ? 
ATOM   1930 N NH2 . ARG A 1 265 ? 22.279  -68.977 14.247  1.000 35.912 0 269  ARG A NH2 1 ? 
ATOM   1931 N N   . VAL A 1 266 ? 18.449  -65.189 11.536  1.000 18.197 0 270  VAL A N   1 ? 
ATOM   1932 C CA  . VAL A 1 266 ? 17.814  -64.694 10.319  1.000 18.344 0 270  VAL A CA  1 ? 
ATOM   1933 C C   . VAL A 1 266 ? 16.377  -65.198 10.324  1.000 18.076 0 270  VAL A C   1 ? 
ATOM   1934 O O   . VAL A 1 266 ? 16.135  -66.414 10.341  1.000 20.273 0 270  VAL A O   1 ? 
ATOM   1935 C CB  . VAL A 1 266 ? 18.570  -65.153 9.062   1.000 18.113 0 270  VAL A CB  1 ? 
ATOM   1936 C CG1 . VAL A 1 266 ? 17.824  -64.727 7.802   1.000 20.671 0 270  VAL A CG1 1 ? 
ATOM   1937 C CG2 . VAL A 1 266 ? 20.007  -64.586 9.069   1.000 19.481 0 270  VAL A CG2 1 ? 
ATOM   1938 N N   . VAL A 1 267 ? 15.430  -64.257 10.333  1.000 17.668 0 271  VAL A N   1 ? 
ATOM   1939 C CA  . VAL A 1 267 ? 14.020  -64.517 10.599  1.000 18.836 0 271  VAL A CA  1 ? 
ATOM   1940 C C   . VAL A 1 267 ? 13.175  -63.707 9.621   1.000 18.760 0 271  VAL A C   1 ? 
ATOM   1941 O O   . VAL A 1 267 ? 13.673  -62.831 8.911   1.000 18.413 0 271  VAL A O   1 ? 
ATOM   1942 C CB  . VAL A 1 267 ? 13.638  -64.140 12.045  1.000 20.937 0 271  VAL A CB  1 ? 
ATOM   1943 C CG1 . VAL A 1 267 ? 14.493  -64.906 13.048  1.000 22.213 0 271  VAL A CG1 1 ? 
ATOM   1944 C CG2 . VAL A 1 267 ? 13.840  -62.629 12.263  1.000 19.302 0 271  VAL A CG2 1 ? 
ATOM   1945 N N   . THR A 1 268 ? 11.869  -63.974 9.621   1.000 20.879 0 272  THR A N   1 ? 
ATOM   1946 C CA  . THR A 1 268 ? 10.932  -63.163 8.856   1.000 21.168 0 272  THR A CA  1 ? 
ATOM   1947 C C   . THR A 1 268 ? 10.090  -62.287 9.781   1.000 21.092 0 272  THR A C   1 ? 
ATOM   1948 O O   . THR A 1 268 ? 9.723   -62.690 10.888  1.000 20.626 0 272  THR A O   1 ? 
ATOM   1949 C CB  . THR A 1 268 ? 9.999   -64.035 8.002   1.000 25.235 0 272  THR A CB  1 ? 
ATOM   1950 O OG1 . THR A 1 268 ? 9.094   -64.749 8.854   1.000 25.793 0 272  THR A OG1 1 ? 
ATOM   1951 C CG2 . THR A 1 268 ? 10.798  -65.048 7.170   1.000 23.984 0 272  THR A CG2 1 ? 
ATOM   1952 N N   . LEU A 1 269 ? 9.770   -61.079 9.313   1.000 19.750 0 273  LEU A N   1 ? 
ATOM   1953 C CA  . LEU A 1 269 ? 8.881   -60.227 10.096  1.000 20.505 0 273  LEU A CA  1 ? 
ATOM   1954 C C   . LEU A 1 269 ? 7.503   -60.870 10.230  1.000 21.476 0 273  LEU A C   1 ? 
ATOM   1955 O O   . LEU A 1 269 ? 6.842   -60.715 11.265  1.000 22.879 0 273  LEU A O   1 ? 
ATOM   1956 C CB  . LEU A 1 269 ? 8.794   -58.832 9.459   1.000 20.445 0 273  LEU A CB  1 ? 
ATOM   1957 C CG  . LEU A 1 269 ? 7.841   -57.814 10.097  1.000 21.679 0 273  LEU A CG  1 ? 
ATOM   1958 C CD1 . LEU A 1 269 ? 8.120   -57.679 11.584  1.000 21.121 0 273  LEU A CD1 1 ? 
ATOM   1959 C CD2 . LEU A 1 269 ? 7.954   -56.456 9.404   1.000 22.942 0 273  LEU A CD2 1 ? 
ATOM   1960 N N   . ASP A 1 270 ? 7.070   -61.631 9.214   1.000 23.103 0 274  ASP A N   1 ? 
ATOM   1961 C CA  . ASP A 1 270 ? 5.812   -62.373 9.329   1.000 23.700 0 274  ASP A CA  1 ? 
ATOM   1962 C C   . ASP A 1 270 ? 5.792   -63.246 10.577  1.000 21.255 0 274  ASP A C   1 ? 
ATOM   1963 O O   . ASP A 1 270 ? 4.732   -63.428 11.196  1.000 26.158 0 274  ASP A O   1 ? 
ATOM   1964 C CB  . ASP A 1 270 ? 5.598   -63.266 8.100   1.000 22.869 0 274  ASP A CB  1 ? 
ATOM   1965 C CG  . ASP A 1 270 ? 5.082   -62.510 6.895   1.000 30.883 0 274  ASP A CG  1 ? 
ATOM   1966 O OD1 . ASP A 1 270 ? 4.755   -61.312 7.026   1.000 29.922 0 274  ASP A OD1 1 ? 
ATOM   1967 O OD2 . ASP A 1 270 ? 5.000   -63.124 5.805   1.000 29.748 0 274  ASP A OD2 1 ? 
ATOM   1968 N N   . ASP A 1 271 ? 6.946   -63.795 10.961  1.000 22.274 0 275  ASP A N   1 ? 
ATOM   1969 C CA  . ASP A 1 271 ? 7.016   -64.661 12.132  1.000 23.269 0 275  ASP A CA  1 ? 
ATOM   1970 C C   . ASP A 1 271 ? 7.181   -63.878 13.435  1.000 25.629 0 275  ASP A C   1 ? 
ATOM   1971 O O   . ASP A 1 271 ? 6.590   -64.254 14.451  1.000 28.388 0 275  ASP A O   1 ? 
ATOM   1972 C CB  . ASP A 1 271 ? 8.173   -65.658 11.993  1.000 22.887 0 275  ASP A CB  1 ? 
ATOM   1973 C CG  . ASP A 1 271 ? 7.886   -66.775 10.999  1.000 28.524 0 275  ASP A CG  1 ? 
ATOM   1974 O OD1 . ASP A 1 271 ? 6.705   -66.990 10.623  1.000 32.220 0 275  ASP A OD1 1 ? 
ATOM   1975 O OD2 . ASP A 1 271 ? 8.853   -67.462 10.611  1.000 27.832 0 275  ASP A OD2 1 ? 
ATOM   1976 N N   . VAL A 1 272 ? 7.985   -62.810 13.450  1.000 21.997 0 276  VAL A N   1 ? 
ATOM   1977 C CA  . VAL A 1 272 ? 8.479   -62.264 14.713  1.000 20.866 0 276  VAL A CA  1 ? 
ATOM   1978 C C   . VAL A 1 272 ? 7.843   -60.925 15.081  1.000 24.269 0 276  VAL A C   1 ? 
ATOM   1979 O O   . VAL A 1 272 ? 8.286   -60.298 16.044  1.000 22.229 0 276  VAL A O   1 ? 
ATOM   1980 C CB  . VAL A 1 272 ? 10.015  -62.135 14.709  1.000 20.576 0 276  VAL A CB  1 ? 
ATOM   1981 C CG1 . VAL A 1 272 ? 10.666  -63.475 14.401  1.000 24.558 0 276  VAL A CG1 1 ? 
ATOM   1982 C CG2 . VAL A 1 272 ? 10.465  -61.044 13.714  1.000 21.629 0 276  VAL A CG2 1 ? 
ATOM   1983 N N   . ALA A 1 273 ? 6.791   -60.482 14.374  1.000 22.850 0 277  ALA A N   1 ? 
ATOM   1984 C CA  . ALA A 1 273 ? 6.276   -59.121 14.589  1.000 22.332 0 277  ALA A CA  1 ? 
ATOM   1985 C C   . ALA A 1 273 ? 5.965   -58.826 16.061  1.000 23.687 0 277  ALA A C   1 ? 
ATOM   1986 O O   . ALA A 1 273 ? 6.233   -57.721 16.547  1.000 23.411 0 277  ALA A O   1 ? 
ATOM   1987 C CB  . ALA A 1 273 ? 5.022   -58.883 13.736  1.000 22.205 0 277  ALA A CB  1 ? 
ATOM   1988 N N   . GLU A 1 274 ? 5.412   -59.798 16.791  1.000 23.603 0 278  GLU A N   1 ? 
ATOM   1989 C CA  . GLU A 1 274 ? 5.035   -59.594 18.189  1.000 22.405 0 278  GLU A CA  1 ? 
ATOM   1990 C C   . GLU A 1 274 ? 6.219   -59.594 19.145  1.000 22.926 0 278  GLU A C   1 ? 
ATOM   1991 O O   . GLU A 1 274 ? 6.048   -59.226 20.314  1.000 24.316 0 278  GLU A O   1 ? 
ATOM   1992 C CB  . GLU A 1 274 ? 4.065   -60.687 18.645  1.000 24.869 0 278  GLU A CB  1 ? 
ATOM   1993 C CG  . GLU A 1 274 ? 2.703   -60.611 18.009  1.000 25.582 0 278  GLU A CG  1 ? 
ATOM   1994 C CD  . GLU A 1 274 ? 2.580   -61.499 16.790  1.000 30.909 0 278  GLU A CD  1 ? 
ATOM   1995 O OE1 . GLU A 1 274 ? 3.624   -62.004 16.312  1.000 29.667 0 278  GLU A OE1 1 ? 
ATOM   1996 O OE2 . GLU A 1 274 ? 1.431   -61.688 16.319  1.000 30.769 0 278  GLU A OE2 1 ? 
ATOM   1997 N N   . GLN A 1 275 ? 7.399   -60.005 18.684  1.000 21.600 0 279  GLN A N   1 ? 
ATOM   1998 C CA  . GLN A 1 275 ? 8.553   -60.231 19.541  1.000 23.213 0 279  GLN A CA  1 ? 
ATOM   1999 C C   . GLN A 1 275 ? 9.550   -59.080 19.545  1.000 23.729 0 279  GLN A C   1 ? 
ATOM   2000 O O   . GLN A 1 275 ? 10.522  -59.138 20.304  1.000 26.874 0 279  GLN A O   1 ? 
ATOM   2001 C CB  . GLN A 1 275 ? 9.300   -61.499 19.104  1.000 27.124 0 279  GLN A CB  1 ? 
ATOM   2002 C CG  . GLN A 1 275 ? 8.466   -62.764 19.014  1.000 35.512 0 279  GLN A CG  1 ? 
ATOM   2003 C CD  . GLN A 1 275 ? 9.205   -63.872 18.277  1.000 42.150 0 279  GLN A CD  1 ? 
ATOM   2004 O OE1 . GLN A 1 275 ? 10.440  -63.912 18.267  1.000 54.988 0 279  GLN A OE1 1 ? 
ATOM   2005 N NE2 . GLN A 1 275 ? 8.458   -64.762 17.642  1.000 50.651 0 279  GLN A NE2 1 ? 
ATOM   2006 N N   . VAL A 1 276 ? 9.364   -58.060 18.716  1.000 20.229 0 280  VAL A N   1 ? 
ATOM   2007 C CA  . VAL A 1 276 ? 10.426  -57.080 18.502  1.000 19.284 0 280  VAL A CA  1 ? 
ATOM   2008 C C   . VAL A 1 276 ? 10.108  -55.781 19.234  1.000 20.939 0 280  VAL A C   1 ? 
ATOM   2009 O O   . VAL A 1 276 ? 8.951   -55.371 19.364  1.000 23.445 0 280  VAL A O   1 ? 
ATOM   2010 C CB  . VAL A 1 276 ? 10.666  -56.829 16.998  1.000 21.874 0 280  VAL A CB  1 ? 
ATOM   2011 C CG1 . VAL A 1 276 ? 11.186  -58.115 16.344  1.000 22.879 0 280  VAL A CG1 1 ? 
ATOM   2012 C CG2 . VAL A 1 276 ? 9.393   -56.339 16.322  1.000 23.937 0 280  VAL A CG2 1 ? 
ATOM   2013 N N   . ASP A 1 277 ? 11.166  -55.126 19.707  1.000 18.350 0 281  ASP A N   1 ? 
ATOM   2014 C CA  . ASP A 1 277 ? 11.062  -53.827 20.359  1.000 19.500 0 281  ASP A CA  1 ? 
ATOM   2015 C C   . ASP A 1 277 ? 11.327  -52.674 19.412  1.000 19.731 0 281  ASP A C   1 ? 
ATOM   2016 O O   . ASP A 1 277 ? 10.803  -51.576 19.624  1.000 20.760 0 281  ASP A O   1 ? 
ATOM   2017 C CB  . ASP A 1 277 ? 12.068  -53.728 21.516  1.000 20.676 0 281  ASP A CB  1 ? 
ATOM   2018 C CG  . ASP A 1 277 ? 11.784  -54.733 22.615  1.000 22.161 0 281  ASP A CG  1 ? 
ATOM   2019 O OD1 . ASP A 1 277 ? 10.659  -54.706 23.166  1.000 22.066 0 281  ASP A OD1 1 ? 
ATOM   2020 O OD2 . ASP A 1 277 ? 12.684  -55.546 22.923  1.000 21.629 0 281  ASP A OD2 1 ? 
ATOM   2021 N N   . ILE A 1 278 ? 12.161  -52.904 18.402  1.000 17.544 0 282  ILE A N   1 ? 
ATOM   2022 C CA  . ILE A 1 278 ? 12.604  -51.889 17.458  1.000 18.802 0 282  ILE A CA  1 ? 
ATOM   2023 C C   . ILE A 1 278 ? 12.643  -52.553 16.094  1.000 20.358 0 282  ILE A C   1 ? 
ATOM   2024 O O   . ILE A 1 278 ? 13.130  -53.679 15.969  1.000 21.050 0 282  ILE A O   1 ? 
ATOM   2025 C CB  . ILE A 1 278 ? 13.998  -51.326 17.814  1.000 19.766 0 282  ILE A CB  1 ? 
ATOM   2026 C CG1 . ILE A 1 278 ? 14.025  -50.698 19.217  1.000 20.637 0 282  ILE A CG1 1 ? 
ATOM   2027 C CG2 . ILE A 1 278 ? 14.453  -50.303 16.753  1.000 24.956 0 282  ILE A CG2 1 ? 
ATOM   2028 C CD1 . ILE A 1 278 ? 15.459  -50.365 19.683  1.000 24.077 0 282  ILE A CD1 1 ? 
ATOM   2029 N N   . VAL A 1 279 ? 12.102  -51.882 15.082  1.000 18.889 0 283  VAL A N   1 ? 
ATOM   2030 C CA  . VAL A 1 279 ? 12.155  -52.357 13.706  1.000 18.076 0 283  VAL A CA  1 ? 
ATOM   2031 C C   . VAL A 1 279 ? 12.802  -51.274 12.857  1.000 19.089 0 283  VAL A C   1 ? 
ATOM   2032 O O   . VAL A 1 279 ? 12.366  -50.116 12.896  1.000 20.342 0 283  VAL A O   1 ? 
ATOM   2033 C CB  . VAL A 1 279 ? 10.756  -52.694 13.157  1.000 21.239 0 283  VAL A CB  1 ? 
ATOM   2034 C CG1 . VAL A 1 279 ? 10.860  -53.103 11.684  1.000 22.966 0 283  VAL A CG1 1 ? 
ATOM   2035 C CG2 . VAL A 1 279 ? 10.109  -53.805 13.971  1.000 22.247 0 283  VAL A CG2 1 ? 
ATOM   2036 N N   . VAL A 1 280 ? 13.818  -51.657 12.081  1.000 17.518 0 284  VAL A N   1 ? 
ATOM   2037 C CA  . VAL A 1 280 ? 14.533  -50.759 11.168  1.000 17.442 0 284  VAL A CA  1 ? 
ATOM   2038 C C   . VAL A 1 280 ? 14.441  -51.323 9.753   1.000 18.329 0 284  VAL A C   1 ? 
ATOM   2039 O O   . VAL A 1 280 ? 14.968  -52.410 9.485   1.000 19.426 0 284  VAL A O   1 ? 
ATOM   2040 C CB  . VAL A 1 280 ? 16.010  -50.602 11.569  1.000 16.899 0 284  VAL A CB  1 ? 
ATOM   2041 C CG1 . VAL A 1 280 ? 16.721  -49.641 10.605  1.000 20.634 0 284  VAL A CG1 1 ? 
ATOM   2042 C CG2 . VAL A 1 280 ? 16.128  -50.139 13.012  1.000 20.231 0 284  VAL A CG2 1 ? 
ATOM   2043 N N   . THR A 1 281 ? 13.800  -50.590 8.836   1.000 19.489 0 285  THR A N   1 ? 
ATOM   2044 C CA  . THR A 1 281 ? 13.758  -51.036 7.440   1.000 17.207 0 285  THR A CA  1 ? 
ATOM   2045 C C   . THR A 1 281 ? 14.961  -50.487 6.679   1.000 18.523 0 285  THR A C   1 ? 
ATOM   2046 O O   . THR A 1 281 ? 15.218  -49.279 6.687   1.000 20.260 0 285  THR A O   1 ? 
ATOM   2047 C CB  . THR A 1 281 ? 12.443  -50.640 6.743   1.000 17.894 0 285  THR A CB  1 ? 
ATOM   2048 O OG1 . THR A 1 281 ? 12.289  -49.214 6.698   1.000 21.621 0 285  THR A OG1 1 ? 
ATOM   2049 C CG2 . THR A 1 281 ? 11.259  -51.223 7.483   1.000 20.960 0 285  THR A CG2 1 ? 
ATOM   2050 N N   . ALA A 1 282 ? 15.705  -51.387 6.034   1.000 18.781 0 286  ALA A N   1 ? 
ATOM   2051 C CA  . ALA A 1 282 ? 16.925  -51.026 5.312   1.000 15.133 0 286  ALA A CA  1 ? 
ATOM   2052 C C   . ALA A 1 282 ? 17.001  -51.793 3.999   1.000 18.663 0 286  ALA A C   1 ? 
ATOM   2053 O O   . ALA A 1 282 ? 18.073  -52.237 3.574   1.000 19.431 0 286  ALA A O   1 ? 
ATOM   2054 C CB  . ALA A 1 282 ? 18.172  -51.291 6.169   1.000 16.491 0 286  ALA A CB  1 ? 
ATOM   2055 N N   . THR A 1 283 ? 15.852  -51.950 3.329   1.000 18.026 0 287  THR A N   1 ? 
ATOM   2056 C CA  . THR A 1 283 ? 15.754  -52.835 2.173   1.000 17.489 0 287  THR A CA  1 ? 
ATOM   2057 C C   . THR A 1 283 ? 15.822  -52.130 0.830   1.000 20.610 0 287  THR A C   1 ? 
ATOM   2058 O O   . THR A 1 283 ? 16.112  -52.794 -0.173  1.000 20.634 0 287  THR A O   1 ? 
ATOM   2059 C CB  . THR A 1 283 ? 14.440  -53.635 2.193   1.000 16.715 0 287  THR A CB  1 ? 
ATOM   2060 O OG1 . THR A 1 283 ? 13.325  -52.749 1.988   1.000 18.915 0 287  THR A OG1 1 ? 
ATOM   2061 C CG2 . THR A 1 283 ? 14.258  -54.376 3.507   1.000 17.523 0 287  THR A CG2 1 ? 
ATOM   2062 N N   . GLY A 1 284 ? 15.505  -50.835 0.765   1.000 18.926 0 288  GLY A N   1 ? 
ATOM   2063 C CA  . GLY A 1 284 ? 15.282  -50.224 -0.534  1.000 17.647 0 288  GLY A CA  1 ? 
ATOM   2064 C C   . GLY A 1 284 ? 14.081  -50.771 -1.283  1.000 20.818 0 288  GLY A C   1 ? 
ATOM   2065 O O   . GLY A 1 284 ? 13.964  -50.554 -2.497  1.000 20.747 0 288  GLY A O   1 ? 
ATOM   2066 N N   . ASN A 1 285 ? 13.175  -51.467 -0.598  1.000 19.687 0 289  ASN A N   1 ? 
ATOM   2067 C CA  . ASN A 1 285 ? 12.069  -52.142 -1.266  1.000 18.268 0 289  ASN A CA  1 ? 
ATOM   2068 C C   . ASN A 1 285 ? 10.733  -51.532 -0.823  1.000 21.279 0 289  ASN A C   1 ? 
ATOM   2069 O O   . ASN A 1 285 ? 10.683  -50.486 -0.164  1.000 21.100 0 289  ASN A O   1 ? 
ATOM   2070 C CB  . ASN A 1 285 ? 12.152  -53.651 -1.009  1.000 20.113 0 289  ASN A CB  1 ? 
ATOM   2071 C CG  . ASN A 1 285 ? 11.593  -54.472 -2.165  1.000 20.524 0 289  ASN A CG  1 ? 
ATOM   2072 O OD1 . ASN A 1 285 ? 10.637  -54.060 -2.826  1.000 21.458 0 289  ASN A OD1 1 ? 
ATOM   2073 N ND2 . ASN A 1 285 ? 12.162  -55.659 -2.388  1.000 20.718 0 289  ASN A ND2 1 ? 
ATOM   2074 N N   . TYR A 1 286 ? 9.645   -52.190 -1.205  1.000 19.313 0 290  TYR A N   1 ? 
ATOM   2075 C CA  . TYR A 1 286 ? 8.308   -51.608 -1.138  1.000 19.273 0 290  TYR A CA  1 ? 
ATOM   2076 C C   . TYR A 1 286 ? 7.449   -52.379 -0.146  1.000 24.908 0 290  TYR A C   1 ? 
ATOM   2077 O O   . TYR A 1 286 ? 7.284   -53.597 -0.280  1.000 21.853 0 290  TYR A O   1 ? 
ATOM   2078 C CB  . TYR A 1 286 ? 7.672   -51.626 -2.527  1.000 20.731 0 290  TYR A CB  1 ? 
ATOM   2079 C CG  . TYR A 1 286 ? 6.344   -50.918 -2.614  1.000 20.737 0 290  TYR A CG  1 ? 
ATOM   2080 C CD1 . TYR A 1 286 ? 6.286   -49.534 -2.711  1.000 20.376 0 290  TYR A CD1 1 ? 
ATOM   2081 C CD2 . TYR A 1 286 ? 5.154   -51.636 -2.630  1.000 22.966 0 290  TYR A CD2 1 ? 
ATOM   2082 C CE1 . TYR A 1 286 ? 5.053   -48.871 -2.810  1.000 22.921 0 290  TYR A CE1 1 ? 
ATOM   2083 C CE2 . TYR A 1 286 ? 3.916   -50.984 -2.722  1.000 21.879 0 290  TYR A CE2 1 ? 
ATOM   2084 C CZ  . TYR A 1 286 ? 3.885   -49.596 -2.815  1.000 25.169 0 290  TYR A CZ  1 ? 
ATOM   2085 O OH  . TYR A 1 286 ? 2.678   -48.916 -2.904  1.000 27.293 0 290  TYR A OH  1 ? 
ATOM   2086 N N   . HIS A 1 287 ? 6.887   -51.663 0.835   1.000 20.981 0 291  HIS A N   1 ? 
ATOM   2087 C CA  . HIS A 1 287 ? 5.930   -52.224 1.795   1.000 20.363 0 291  HIS A CA  1 ? 
ATOM   2088 C C   . HIS A 1 287 ? 6.464   -53.497 2.450   1.000 22.779 0 291  HIS A C   1 ? 
ATOM   2089 O O   . HIS A 1 287 ? 5.799   -54.538 2.487   1.000 24.282 0 291  HIS A O   1 ? 
ATOM   2090 C CB  . HIS A 1 287 ? 4.579   -52.482 1.125   1.000 23.545 0 291  HIS A CB  1 ? 
ATOM   2091 C CG  . HIS A 1 287 ? 3.822   -51.233 0.790   1.000 21.876 0 291  HIS A CG  1 ? 
ATOM   2092 N ND1 . HIS A 1 287 ? 2.529   -51.258 0.312   1.000 24.277 0 291  HIS A ND1 1 ? 
ATOM   2093 C CD2 . HIS A 1 287 ? 4.165   -49.925 0.882   1.000 25.950 0 291  HIS A CD2 1 ? 
ATOM   2094 C CE1 . HIS A 1 287 ? 2.113   -50.021 0.106   1.000 28.167 0 291  HIS A CE1 1 ? 
ATOM   2095 N NE2 . HIS A 1 287 ? 3.081   -49.193 0.457   1.000 24.998 0 291  HIS A NE2 1 ? 
ATOM   2096 N N   . VAL A 1 288 ? 7.682   -53.400 2.993   1.000 18.789 0 292  VAL A N   1 ? 
ATOM   2097 C CA  . VAL A 1 288 ? 8.217   -54.519 3.754   1.000 19.950 0 292  VAL A CA  1 ? 
ATOM   2098 C C   . VAL A 1 288 ? 7.669   -54.527 5.175   1.000 21.645 0 292  VAL A C   1 ? 
ATOM   2099 O O   . VAL A 1 288 ? 7.776   -55.545 5.864   1.000 22.847 0 292  VAL A O   1 ? 
ATOM   2100 C CB  . VAL A 1 288 ? 9.760   -54.514 3.755   1.000 20.073 0 292  VAL A CB  1 ? 
ATOM   2101 C CG1 . VAL A 1 288 ? 10.279  -54.666 2.324   1.000 21.429 0 292  VAL A CG1 1 ? 
ATOM   2102 C CG2 . VAL A 1 288 ? 10.326  -53.235 4.389   1.000 21.866 0 292  VAL A CG2 1 ? 
ATOM   2103 N N   . VAL A 1 289 ? 7.074   -53.425 5.626   1.000 21.603 0 293  VAL A N   1 ? 
ATOM   2104 C CA  . VAL A 1 289 ? 6.313   -53.385 6.870   1.000 21.421 0 293  VAL A CA  1 ? 
ATOM   2105 C C   . VAL A 1 289 ? 4.887   -53.018 6.500   1.000 22.819 0 293  VAL A C   1 ? 
ATOM   2106 O O   . VAL A 1 289 ? 4.645   -51.921 5.983   1.000 24.006 0 293  VAL A O   1 ? 
ATOM   2107 C CB  . VAL A 1 289 ? 6.893   -52.386 7.883   1.000 21.368 0 293  VAL A CB  1 ? 
ATOM   2108 C CG1 . VAL A 1 289 ? 5.958   -52.280 9.110   1.000 21.163 0 293  VAL A CG1 1 ? 
ATOM   2109 C CG2 . VAL A 1 289 ? 8.284   -52.827 8.328   1.000 19.008 0 293  VAL A CG2 1 ? 
ATOM   2110 N N   . THR A 1 290 ? 3.956   -53.936 6.752   1.000 23.258 0 294  THR A N   1 ? 
ATOM   2111 C CA  . THR A 1 290 ? 2.558   -53.813 6.353   1.000 23.032 0 294  THR A CA  1 ? 
ATOM   2112 C C   . THR A 1 290 ? 1.677   -53.452 7.547   1.000 24.692 0 294  THR A C   1 ? 
ATOM   2113 O O   . THR A 1 290 ? 2.110   -53.453 8.701   1.000 23.882 0 294  THR A O   1 ? 
ATOM   2114 C CB  . THR A 1 290 ? 2.059   -55.131 5.742   1.000 25.248 0 294  THR A CB  1 ? 
ATOM   2115 O OG1 . THR A 1 290 ? 1.977   -56.116 6.778   1.000 29.740 0 294  THR A OG1 1 ? 
ATOM   2116 C CG2 . THR A 1 290 ? 3.016   -55.631 4.672   1.000 28.669 0 294  THR A CG2 1 ? 
ATOM   2117 N N   . HIS A 1 291 ? 0.410   -53.158 7.251   1.000 23.921 0 295  HIS A N   1 ? 
ATOM   2118 C CA  . HIS A 1 291 ? -0.553  -52.869 8.314   1.000 21.537 0 295  HIS A CA  1 ? 
ATOM   2119 C C   . HIS A 1 291 ? -0.602  -53.988 9.344   1.000 25.611 0 295  HIS A C   1 ? 
ATOM   2120 O O   . HIS A 1 291 ? -0.615  -53.732 10.553  1.000 24.616 0 295  HIS A O   1 ? 
ATOM   2121 C CB  . HIS A 1 291 ? -1.962  -52.654 7.741   1.000 23.542 0 295  HIS A CB  1 ? 
ATOM   2122 C CG  . HIS A 1 291 ? -2.995  -52.393 8.793   1.000 26.653 0 295  HIS A CG  1 ? 
ATOM   2123 N ND1 . HIS A 1 291 ? -3.637  -53.404 9.478   1.000 27.230 0 295  HIS A ND1 1 ? 
ATOM   2124 C CD2 . HIS A 1 291 ? -3.469  -51.232 9.307   1.000 27.619 0 295  HIS A CD2 1 ? 
ATOM   2125 C CE1 . HIS A 1 291 ? -4.469  -52.879 10.362  1.000 27.132 0 295  HIS A CE1 1 ? 
ATOM   2126 N NE2 . HIS A 1 291 ? -4.390  -51.563 10.275  1.000 27.511 0 295  HIS A NE2 1 ? 
ATOM   2127 N N   . ASP A 1 292 ? -0.669  -55.240 8.884   1.000 23.311 0 296  ASP A N   1 ? 
ATOM   2128 C CA  . ASP A 1 292 ? -0.827  -56.338 9.831   1.000 25.866 0 296  ASP A CA  1 ? 
ATOM   2129 C C   . ASP A 1 292 ? 0.405   -56.493 10.702  1.000 24.529 0 296  ASP A C   1 ? 
ATOM   2130 O O   . ASP A 1 292 ? 0.283   -56.861 11.876  1.000 24.977 0 296  ASP A O   1 ? 
ATOM   2131 C CB  . ASP A 1 292 ? -1.114  -57.649 9.109   1.000 29.943 0 296  ASP A CB  1 ? 
ATOM   2132 C CG  . ASP A 1 292 ? -1.763  -58.686 10.018  1.000 29.561 0 296  ASP A CG  1 ? 
ATOM   2133 O OD1 . ASP A 1 292 ? -2.767  -58.361 10.691  1.000 29.430 0 296  ASP A OD1 1 ? 
ATOM   2134 O OD2 . ASP A 1 292 ? -1.278  -59.832 10.056  1.000 30.459 0 296  ASP A OD2 1 ? 
ATOM   2135 N N   . HIS A 1 293 ? 1.592   -56.236 10.145  1.000 22.192 0 297  HIS A N   1 ? 
ATOM   2136 C CA  . HIS A 1 293 ? 2.800   -56.231 10.965  1.000 22.900 0 297  HIS A CA  1 ? 
ATOM   2137 C C   . HIS A 1 293 ? 2.668   -55.228 12.095  1.000 22.447 0 297  HIS A C   1 ? 
ATOM   2138 O O   . HIS A 1 293 ? 2.918   -55.547 13.264  1.000 24.700 0 297  HIS A O   1 ? 
ATOM   2139 C CB  . HIS A 1 293 ? 4.027   -55.888 10.116  1.000 22.455 0 297  HIS A CB  1 ? 
ATOM   2140 C CG  . HIS A 1 293 ? 4.396   -56.940 9.121   1.000 24.313 0 297  HIS A CG  1 ? 
ATOM   2141 N ND1 . HIS A 1 293 ? 4.950   -56.632 7.897   1.000 25.108 0 297  HIS A ND1 1 ? 
ATOM   2142 C CD2 . HIS A 1 293 ? 4.307   -58.291 9.168   1.000 23.421 0 297  HIS A CD2 1 ? 
ATOM   2143 C CE1 . HIS A 1 293 ? 5.181   -57.749 7.229   1.000 26.314 0 297  HIS A CE1 1 ? 
ATOM   2144 N NE2 . HIS A 1 293 ? 4.801   -58.771 7.977   1.000 22.805 0 297  HIS A NE2 1 ? 
ATOM   2145 N N   . MET A 1 294 ? 2.254   -54.009 11.759  1.000 24.729 0 298  MET A N   1 ? 
ATOM   2146 C CA  . MET A 1 294 ? 2.169   -52.953 12.758  1.000 22.613 0 298  MET A CA  1 ? 
ATOM   2147 C C   . MET A 1 294 ? 1.066   -53.228 13.772  1.000 25.679 0 298  MET A C   1 ? 
ATOM   2148 O O   . MET A 1 294 ? 1.234   -52.946 14.963  1.000 25.464 0 298  MET A O   1 ? 
ATOM   2149 C CB  . MET A 1 294 ? 1.984   -51.606 12.058  1.000 22.861 0 298  MET A CB  1 ? 
ATOM   2150 C CG  . MET A 1 294 ? 3.201   -51.258 11.168  1.000 21.366 0 298  MET A CG  1 ? 
ATOM   2151 S SD  . MET A 1 294 ? 3.105   -49.629 10.419  1.000 24.737 0 298  MET A SD  1 ? 
ATOM   2152 C CE  . MET A 1 294 ? 2.083   -49.958 8.972   1.000 24.377 0 298  MET A CE  1 ? 
ATOM   2153 N N   . LYS A 1 295 ? -0.053  -53.811 13.326  1.000 23.005 0 299  LYS A N   1 ? 
ATOM   2154 C CA  . LYS A 1 295 ? -1.118  -54.198 14.251  1.000 24.192 0 299  LYS A CA  1 ? 
ATOM   2155 C C   . LYS A 1 295 ? -0.620  -55.201 15.283  1.000 28.377 0 299  LYS A C   1 ? 
ATOM   2156 O O   . LYS A 1 295 ? -1.062  -55.175 16.437  1.000 25.893 0 299  LYS A O   1 ? 
ATOM   2157 C CB  . LYS A 1 295 ? -2.307  -54.777 13.472  1.000 25.171 0 299  LYS A CB  1 ? 
ATOM   2158 C CG  . LYS A 1 295 ? -3.478  -55.238 14.353  1.000 33.762 0 299  LYS A CG  1 ? 
ATOM   2159 C CD  . LYS A 1 295 ? -4.180  -56.424 13.710  1.000 41.276 0 299  LYS A CD  1 ? 
ATOM   2160 C CE  . LYS A 1 295 ? -5.461  -56.788 14.432  1.000 48.522 0 299  LYS A CE  1 ? 
ATOM   2161 N NZ  . LYS A 1 295 ? -6.070  -58.005 13.824  1.000 54.786 0 299  LYS A NZ  1 ? 
ATOM   2162 N N   . ARG A 1 296 ? 0.318   -56.068 14.898  1.000 25.732 0 300  ARG A N   1 ? 
ATOM   2163 C CA  . ARG A 1 296 ? 0.838   -57.106 15.784  1.000 24.361 0 300  ARG A CA  1 ? 
ATOM   2164 C C   . ARG A 1 296 ? 1.963   -56.629 16.698  1.000 24.269 0 300  ARG A C   1 ? 
ATOM   2165 O O   . ARG A 1 296 ? 2.353   -57.378 17.600  1.000 25.711 0 300  ARG A O   1 ? 
ATOM   2166 C CB  . ARG A 1 296 ? 1.346   -58.296 14.961  1.000 23.195 0 300  ARG A CB  1 ? 
ATOM   2167 C CG  . ARG A 1 296 ? 0.240   -59.005 14.159  1.000 21.713 0 300  ARG A CG  1 ? 
ATOM   2168 C CD  . ARG A 1 296 ? 0.839   -59.901 13.060  1.000 23.440 0 300  ARG A CD  1 ? 
ATOM   2169 N NE  . ARG A 1 296 ? 1.735   -60.900 13.638  1.000 24.629 0 300  ARG A NE  1 ? 
ATOM   2170 C CZ  . ARG A 1 296 ? 2.603   -61.620 12.932  1.000 27.072 0 300  ARG A CZ  1 ? 
ATOM   2171 N NH1 . ARG A 1 296 ? 2.675   -61.465 11.615  1.000 27.656 0 300  ARG A NH1 1 ? 
ATOM   2172 N NH2 . ARG A 1 296 ? 3.397   -62.494 13.545  1.000 27.156 0 300  ARG A NH2 1 ? 
ATOM   2173 N N   . MET A 1 297 ? 2.486   -55.422 16.495  1.000 24.253 0 301  MET A N   1 ? 
ATOM   2174 C CA  . MET A 1 297 ? 3.653   -54.964 17.244  1.000 22.361 0 301  MET A CA  1 ? 
ATOM   2175 C C   . MET A 1 297 ? 3.274   -54.638 18.684  1.000 23.577 0 301  MET A C   1 ? 
ATOM   2176 O O   . MET A 1 297 ? 2.130   -54.284 18.981  1.000 25.935 0 301  MET A O   1 ? 
ATOM   2177 C CB  . MET A 1 297 ? 4.263   -53.739 16.569  1.000 25.664 0 301  MET A CB  1 ? 
ATOM   2178 C CG  . MET A 1 297 ? 4.873   -54.090 15.239  1.000 27.280 0 301  MET A CG  1 ? 
ATOM   2179 S SD  . MET A 1 297 ? 5.786   -52.785 14.437  1.000 29.235 0 301  MET A SD  1 ? 
ATOM   2180 C CE  . MET A 1 297 ? 4.689   -51.381 14.412  1.000 48.335 0 301  MET A CE  1 ? 
ATOM   2181 N N   . ARG A 1 298 ? 4.248   -54.776 19.590  1.000 22.087 0 302  ARG A N   1 ? 
ATOM   2182 C CA  . ARG A 1 298 ? 3.973   -54.519 20.999  1.000 23.850 0 302  ARG A CA  1 ? 
ATOM   2183 C C   . ARG A 1 298 ? 3.739   -53.028 21.238  1.000 26.906 0 302  ARG A C   1 ? 
ATOM   2184 O O   . ARG A 1 298 ? 4.165   -52.168 20.458  1.000 24.419 0 302  ARG A O   1 ? 
ATOM   2185 C CB  . ARG A 1 298 ? 5.123   -55.028 21.880  1.000 25.972 0 302  ARG A CB  1 ? 
ATOM   2186 C CG  . ARG A 1 298 ? 6.430   -54.309 21.697  1.000 30.246 0 302  ARG A CG  1 ? 
ATOM   2187 C CD  . ARG A 1 298 ? 7.576   -55.085 22.388  1.000 35.675 0 302  ARG A CD  1 ? 
ATOM   2188 N NE  . ARG A 1 298 ? 7.339   -56.532 22.374  1.000 41.176 0 302  ARG A NE  1 ? 
ATOM   2189 C CZ  . ARG A 1 298 ? 8.211   -57.470 22.756  1.000 46.853 0 302  ARG A CZ  1 ? 
ATOM   2190 N NH1 . ARG A 1 298 ? 9.442   -57.160 23.200  1.000 36.786 0 302  ARG A NH1 1 ? 
ATOM   2191 N NH2 . ARG A 1 298 ? 7.845   -58.739 22.692  1.000 43.087 0 302  ARG A NH2 1 ? 
ATOM   2192 N N   . ASN A 1 299 ? 3.032   -52.728 22.329  1.000 24.282 0 303  ASN A N   1 ? 
ATOM   2193 C CA  . ASN A 1 299 ? 2.841   -51.342 22.744  1.000 23.855 0 303  ASN A CA  1 ? 
ATOM   2194 C C   . ASN A 1 299 ? 4.190   -50.644 22.905  1.000 24.727 0 303  ASN A C   1 ? 
ATOM   2195 O O   . ASN A 1 299 ? 5.122   -51.200 23.498  1.000 24.969 0 303  ASN A O   1 ? 
ATOM   2196 C CB  . ASN A 1 299 ? 2.063   -51.305 24.061  1.000 24.566 0 303  ASN A CB  1 ? 
ATOM   2197 C CG  . ASN A 1 299 ? 1.656   -49.903 24.464  1.000 29.538 0 303  ASN A CG  1 ? 
ATOM   2198 O OD1 . ASN A 1 299 ? 0.998   -49.193 23.706  1.000 28.396 0 303  ASN A OD1 1 ? 
ATOM   2199 N ND2 . ASN A 1 299 ? 2.028   -49.505 25.677  1.000 28.267 0 303  ASN A ND2 1 ? 
ATOM   2200 N N   . GLN A 1 300 ? 4.292   -49.430 22.351  1.000 23.358 0 304  GLN A N   1 ? 
ATOM   2201 C CA  . GLN A 1 300 ? 5.473   -48.561 22.364  1.000 24.124 0 304  GLN A CA  1 ? 
ATOM   2202 C C   . GLN A 1 300 ? 6.629   -49.106 21.538  1.000 22.432 0 304  GLN A C   1 ? 
ATOM   2203 O O   . GLN A 1 300 ? 7.757   -48.609 21.669  1.000 22.929 0 304  GLN A O   1 ? 
ATOM   2204 C CB  . GLN A 1 300 ? 5.971   -48.257 23.785  1.000 25.624 0 304  GLN A CB  1 ? 
ATOM   2205 C CG  . GLN A 1 300 ? 4.898   -47.685 24.723  1.000 25.737 0 304  GLN A CG  1 ? 
ATOM   2206 C CD  . GLN A 1 300 ? 4.501   -46.250 24.393  1.000 28.764 0 304  GLN A CD  1 ? 
ATOM   2207 O OE1 . GLN A 1 300 ? 5.077   -45.619 23.507  1.000 25.045 0 304  GLN A OE1 1 ? 
ATOM   2208 N NE2 . GLN A 1 300 ? 3.499   -45.733 25.111  1.000 28.875 0 304  GLN A NE2 1 ? 
ATOM   2209 N N   . ALA A 1 301 ? 6.392   -50.106 20.690  1.000 21.610 0 305  ALA A N   1 ? 
ATOM   2210 C CA  . ALA A 1 301 ? 7.424   -50.529 19.747  1.000 21.847 0 305  ALA A CA  1 ? 
ATOM   2211 C C   . ALA A 1 301 ? 7.833   -49.352 18.868  1.000 21.213 0 305  ALA A C   1 ? 
ATOM   2212 O O   . ALA A 1 301 ? 7.018   -48.493 18.531  1.000 24.203 0 305  ALA A O   1 ? 
ATOM   2213 C CB  . ALA A 1 301 ? 6.906   -51.680 18.878  1.000 25.627 0 305  ALA A CB  1 ? 
ATOM   2214 N N   . ILE A 1 302 ? 9.112   -49.318 18.490  1.000 19.115 0 306  ILE A N   1 ? 
ATOM   2215 C CA  . ILE A 1 302 ? 9.671   -48.228 17.698  1.000 18.721 0 306  ILE A CA  1 ? 
ATOM   2216 C C   . ILE A 1 302 ? 9.864   -48.711 16.272  1.000 20.879 0 306  ILE A C   1 ? 
ATOM   2217 O O   . ILE A 1 302 ? 10.529  -49.726 16.037  1.000 22.118 0 306  ILE A O   1 ? 
ATOM   2218 C CB  . ILE A 1 302 ? 10.998  -47.734 18.289  1.000 20.981 0 306  ILE A CB  1 ? 
ATOM   2219 C CG1 . ILE A 1 302 ? 10.718  -47.077 19.637  1.000 25.148 0 306  ILE A CG1 1 ? 
ATOM   2220 C CG2 . ILE A 1 302 ? 11.683  -46.769 17.319  1.000 22.653 0 306  ILE A CG2 1 ? 
ATOM   2221 C CD1 . ILE A 1 302 ? 11.957  -46.922 20.463  1.000 25.714 0 306  ILE A CD1 1 ? 
ATOM   2222 N N   . LEU A 1 303 ? 9.288   -47.980 15.323  1.000 20.221 0 307  LEU A N   1 ? 
ATOM   2223 C CA  . LEU A 1 303 ? 9.369   -48.323 13.910  1.000 19.365 0 307  LEU A CA  1 ? 
ATOM   2224 C C   . LEU A 1 303 ? 10.036  -47.180 13.163  1.000 19.194 0 307  LEU A C   1 ? 
ATOM   2225 O O   . LEU A 1 303 ? 9.620   -46.021 13.289  1.000 21.195 0 307  LEU A O   1 ? 
ATOM   2226 C CB  . LEU A 1 303 ? 7.966   -48.602 13.344  1.000 19.105 0 307  LEU A CB  1 ? 
ATOM   2227 C CG  . LEU A 1 303 ? 7.881   -48.736 11.823  1.000 21.818 0 307  LEU A CG  1 ? 
ATOM   2228 C CD1 . LEU A 1 303 ? 8.721   -49.907 11.334  1.000 21.721 0 307  LEU A CD1 1 ? 
ATOM   2229 C CD2 . LEU A 1 303 ? 6.418   -48.913 11.434  1.000 25.006 0 307  LEU A CD2 1 ? 
ATOM   2230 N N   . CYS A 1 304 ? 11.073  -47.499 12.394  1.000 19.292 0 308  CYS A N   1 ? 
ATOM   2231 C CA  . CYS A 1 304 ? 11.736  -46.467 11.614  1.000 19.010 0 308  CYS A CA  1 ? 
ATOM   2232 C C   . CYS A 1 304 ? 12.271  -47.066 10.324  1.000 20.845 0 308  CYS A C   1 ? 
ATOM   2233 O O   . CYS A 1 304 ? 12.356  -48.286 10.154  1.000 20.050 0 308  CYS A O   1 ? 
ATOM   2234 C CB  . CYS A 1 304 ? 12.851  -45.783 12.413  1.000 21.242 0 308  CYS A CB  1 ? 
ATOM   2235 S SG  . CYS A 1 304 ? 14.269  -46.827 12.775  1.000 21.676 0 308  CYS A SG  1 ? 
ATOM   2236 N N   . ASN A 1 305 ? 12.612  -46.172 9.404   1.000 19.026 0 309  ASN A N   1 ? 
ATOM   2237 C CA  . ASN A 1 305 ? 13.114  -46.523 8.088   1.000 18.697 0 309  ASN A CA  1 ? 
ATOM   2238 C C   . ASN A 1 305 ? 14.420  -45.781 7.860   1.000 19.797 0 309  ASN A C   1 ? 
ATOM   2239 O O   . ASN A 1 305 ? 14.489  -44.566 8.068   1.000 20.713 0 309  ASN A O   1 ? 
ATOM   2240 C CB  . ASN A 1 305 ? 12.097  -46.147 7.004   1.000 20.560 0 309  ASN A CB  1 ? 
ATOM   2241 C CG  . ASN A 1 305 ? 12.711  -46.139 5.630   1.000 22.895 0 309  ASN A CG  1 ? 
ATOM   2242 O OD1 . ASN A 1 305 ? 13.295  -47.131 5.204   1.000 20.781 0 309  ASN A OD1 1 ? 
ATOM   2243 N ND2 . ASN A 1 305 ? 12.603  -45.008 4.933   1.000 24.003 0 309  ASN A ND2 1 ? 
ATOM   2244 N N   . ILE A 1 306 ? 15.454  -46.509 7.444   1.000 16.589 0 310  ILE A N   1 ? 
ATOM   2245 C CA  . ILE A 1 306 ? 16.723  -45.901 7.067   1.000 17.468 0 310  ILE A CA  1 ? 
ATOM   2246 C C   . ILE A 1 306 ? 17.033  -46.104 5.590   1.000 20.624 0 310  ILE A C   1 ? 
ATOM   2247 O O   . ILE A 1 306 ? 18.070  -45.632 5.110   1.000 19.476 0 310  ILE A O   1 ? 
ATOM   2248 C CB  . ILE A 1 306 ? 17.864  -46.419 7.969   1.000 17.684 0 310  ILE A CB  1 ? 
ATOM   2249 C CG1 . ILE A 1 306 ? 19.090  -45.480 7.944   1.000 19.121 0 310  ILE A CG1 1 ? 
ATOM   2250 C CG2 . ILE A 1 306 ? 18.210  -47.871 7.646   1.000 20.181 0 310  ILE A CG2 1 ? 
ATOM   2251 C CD1 . ILE A 1 306 ? 19.999  -45.658 9.140   1.000 21.513 0 310  ILE A CD1 1 ? 
ATOM   2252 N N   . GLY A 1 307 ? 16.133  -46.756 4.841   1.000 19.771 0 311  GLY A N   1 ? 
ATOM   2253 C CA  . GLY A 1 307 ? 16.209  -46.780 3.393   1.000 18.128 0 311  GLY A CA  1 ? 
ATOM   2254 C C   . GLY A 1 307 ? 15.747  -45.463 2.789   1.000 18.626 0 311  GLY A C   1 ? 
ATOM   2255 O O   . GLY A 1 307 ? 15.208  -44.593 3.468   1.000 22.139 0 311  GLY A O   1 ? 
ATOM   2256 N N   . HIS A 1 308 ? 15.957  -45.324 1.478   1.000 19.502 0 312  HIS A N   1 ? 
ATOM   2257 C CA  . HIS A 1 308 ? 15.799  -44.009 0.862   1.000 18.744 0 312  HIS A CA  1 ? 
ATOM   2258 C C   . HIS A 1 308 ? 14.361  -43.487 0.921   1.000 20.976 0 312  HIS A C   1 ? 
ATOM   2259 O O   . HIS A 1 308 ? 14.144  -42.285 1.138   1.000 21.292 0 312  HIS A O   1 ? 
ATOM   2260 C CB  . HIS A 1 308 ? 16.258  -44.022 -0.586  1.000 21.513 0 312  HIS A CB  1 ? 
ATOM   2261 C CG  . HIS A 1 308 ? 16.278  -42.651 -1.172  1.000 20.073 0 312  HIS A CG  1 ? 
ATOM   2262 N ND1 . HIS A 1 308 ? 17.243  -41.724 -0.836  1.000 21.858 0 312  HIS A ND1 1 ? 
ATOM   2263 C CD2 . HIS A 1 308 ? 15.399  -42.009 -1.977  1.000 23.587 0 312  HIS A CD2 1 ? 
ATOM   2264 C CE1 . HIS A 1 308 ? 16.987  -40.586 -1.455  1.000 22.958 0 312  HIS A CE1 1 ? 
ATOM   2265 N NE2 . HIS A 1 308 ? 15.869  -40.730 -2.148  1.000 21.634 0 312  HIS A NE2 1 ? 
ATOM   2266 N N   . PHE A 1 309 ? 13.366  -44.347 0.686   1.000 21.300 0 313  PHE A N   1 ? 
ATOM   2267 C CA  . PHE A 1 309 ? 11.982  -43.898 0.539   1.000 20.829 0 313  PHE A CA  1 ? 
ATOM   2268 C C   . PHE A 1 309 ? 11.094  -44.427 1.660   1.000 20.660 0 313  PHE A C   1 ? 
ATOM   2269 O O   . PHE A 1 309 ? 11.258  -45.564 2.111   1.000 21.889 0 313  PHE A O   1 ? 
ATOM   2270 C CB  . PHE A 1 309 ? 11.398  -44.345 -0.801  1.000 22.237 0 313  PHE A CB  1 ? 
ATOM   2271 C CG  . PHE A 1 309 ? 11.880  -43.535 -1.985  1.000 21.771 0 313  PHE A CG  1 ? 
ATOM   2272 C CD1 . PHE A 1 309 ? 11.751  -42.153 -2.000  1.000 23.842 0 313  PHE A CD1 1 ? 
ATOM   2273 C CD2 . PHE A 1 309 ? 12.459  -44.167 -3.073  1.000 22.834 0 313  PHE A CD2 1 ? 
ATOM   2274 C CE1 . PHE A 1 309 ? 12.183  -41.411 -3.101  1.000 24.640 0 313  PHE A CE1 1 ? 
ATOM   2275 C CE2 . PHE A 1 309 ? 12.893  -43.440 -4.174  1.000 24.063 0 313  PHE A CE2 1 ? 
ATOM   2276 C CZ  . PHE A 1 309 ? 12.759  -42.058 -4.187  1.000 22.755 0 313  PHE A CZ  1 ? 
ATOM   2277 N N   . ASP A 1 310 ? 10.125  -43.601 2.080   1.000 21.929 0 314  ASP A N   1 ? 
ATOM   2278 C CA  . ASP A 1 310 ? 9.186   -43.988 3.126   1.000 21.634 0 314  ASP A CA  1 ? 
ATOM   2279 C C   . ASP A 1 310 ? 8.279   -45.134 2.703   1.000 20.871 0 314  ASP A C   1 ? 
ATOM   2280 O O   . ASP A 1 310 ? 7.644   -45.746 3.567   1.000 22.982 0 314  ASP A O   1 ? 
ATOM   2281 C CB  . ASP A 1 310 ? 8.337   -42.780 3.545   1.000 22.613 0 314  ASP A CB  1 ? 
ATOM   2282 C CG  . ASP A 1 310 ? 7.485   -42.241 2.408   1.000 26.774 0 314  ASP A CG  1 ? 
ATOM   2283 O OD1 . ASP A 1 310 ? 6.337   -42.711 2.250   1.000 29.001 0 314  ASP A OD1 1 ? 
ATOM   2284 O OD2 . ASP A 1 310 ? 7.961   -41.348 1.668   1.000 31.183 0 314  ASP A OD2 1 ? 
ATOM   2285 N N   . SER A 1 311 ? 8.233   -45.469 1.413   1.000 22.416 0 315  SER A N   1 ? 
ATOM   2286 C CA  . SER A 1 311 ? 7.415   -46.581 0.952   1.000 24.529 0 315  SER A CA  1 ? 
ATOM   2287 C C   . SER A 1 311 ? 7.893   -47.951 1.439   1.000 19.887 0 315  SER A C   1 ? 
ATOM   2288 O O   . SER A 1 311 ? 7.212   -48.944 1.158   1.000 20.918 0 315  SER A O   1 ? 
ATOM   2289 C CB  . SER A 1 311 ? 7.334   -46.567 -0.579  1.000 30.506 0 315  SER A CB  1 ? 
ATOM   2290 O OG  . SER A 1 311 ? 8.616   -46.396 -1.153  1.000 31.517 0 315  SER A OG  1 ? 
ATOM   2291 N N   . GLU A 1 312 ? 9.033   -48.052 2.144   1.000 19.408 0 316  GLU A N   1 ? 
ATOM   2292 C CA  . GLU A 1 312 ? 9.340   -49.316 2.815   1.000 18.815 0 316  GLU A CA  1 ? 
ATOM   2293 C C   . GLU A 1 312 ? 8.243   -49.698 3.803   1.000 19.239 0 316  GLU A C   1 ? 
ATOM   2294 O O   . GLU A 1 312 ? 8.045   -50.889 4.080   1.000 21.813 0 316  GLU A O   1 ? 
ATOM   2295 C CB  . GLU A 1 312 ? 10.687  -49.241 3.542   1.000 18.894 0 316  GLU A CB  1 ? 
ATOM   2296 C CG  . GLU A 1 312 ? 11.841  -48.770 2.649   1.000 19.931 0 316  GLU A CG  1 ? 
ATOM   2297 C CD  . GLU A 1 312 ? 13.176  -49.507 2.853   1.000 22.782 0 316  GLU A CD  1 ? 
ATOM   2298 O OE1 . GLU A 1 312 ? 14.167  -49.047 2.259   1.000 21.005 0 316  GLU A OE1 1 ? 
ATOM   2299 O OE2 . GLU A 1 312 ? 13.253  -50.526 3.578   1.000 21.147 0 316  GLU A OE2 1 ? 
ATOM   2300 N N   . ILE A 1 313 ? 7.524   -48.710 4.339   1.000 21.889 0 317  ILE A N   1 ? 
ATOM   2301 C CA  . ILE A 1 313 ? 6.437   -48.925 5.300   1.000 19.958 0 317  ILE A CA  1 ? 
ATOM   2302 C C   . ILE A 1 313 ? 5.128   -48.483 4.664   1.000 21.963 0 317  ILE A C   1 ? 
ATOM   2303 O O   . ILE A 1 313 ? 5.076   -47.444 3.998   1.000 25.458 0 317  ILE A O   1 ? 
ATOM   2304 C CB  . ILE A 1 313 ? 6.684   -48.137 6.606   1.000 21.984 0 317  ILE A CB  1 ? 
ATOM   2305 C CG1 . ILE A 1 313 ? 7.986   -48.577 7.280   1.000 21.197 0 317  ILE A CG1 1 ? 
ATOM   2306 C CG2 . ILE A 1 313 ? 5.507   -48.279 7.570   1.000 24.645 0 317  ILE A CG2 1 ? 
ATOM   2307 C CD1 . ILE A 1 313 ? 8.550   -47.523 8.216   1.000 23.505 0 317  ILE A CD1 1 ? 
ATOM   2308 N N   . ASP A 1 314 ? 4.059   -49.262 4.867   1.000 21.608 0 318  ASP A N   1 ? 
ATOM   2309 C CA  . ASP A 1 314 ? 2.753   -48.836 4.360   1.000 24.063 0 318  ASP A CA  1 ? 
ATOM   2310 C C   . ASP A 1 314 ? 2.135   -47.815 5.324   1.000 29.009 0 318  ASP A C   1 ? 
ATOM   2311 O O   . ASP A 1 314 ? 1.191   -48.088 6.071   1.000 26.340 0 318  ASP A O   1 ? 
ATOM   2312 C CB  . ASP A 1 314 ? 1.821   -50.020 4.124   1.000 23.992 0 318  ASP A CB  1 ? 
ATOM   2313 C CG  . ASP A 1 314 ? 0.567   -49.612 3.361   1.000 28.024 0 318  ASP A CG  1 ? 
ATOM   2314 O OD1 . ASP A 1 314 ? 0.566   -48.515 2.765   1.000 30.085 0 318  ASP A OD1 1 ? 
ATOM   2315 O OD2 . ASP A 1 314 ? -0.422  -50.376 3.347   1.000 25.779 0 318  ASP A OD2 1 ? 
ATOM   2316 N N   . ILE A 1 315 ? 2.674   -46.594 5.260   1.000 24.935 0 319  ILE A N   1 ? 
ATOM   2317 C CA  . ILE A 1 315 ? 2.221   -45.515 6.135   1.000 27.403 0 319  ILE A CA  1 ? 
ATOM   2318 C C   . ILE A 1 315 ? 0.756   -45.189 5.869   1.000 28.727 0 319  ILE A C   1 ? 
ATOM   2319 O O   . ILE A 1 315 ? 0.001   -44.858 6.793   1.000 29.177 0 319  ILE A O   1 ? 
ATOM   2320 C CB  . ILE A 1 315 ? 3.125   -44.279 5.952   1.000 26.253 0 319  ILE A CB  1 ? 
ATOM   2321 C CG1 . ILE A 1 315 ? 4.548   -44.587 6.428   1.000 26.508 0 319  ILE A CG1 1 ? 
ATOM   2322 C CG2 . ILE A 1 315 ? 2.538   -43.075 6.689   1.000 30.017 0 319  ILE A CG2 1 ? 
ATOM   2323 C CD1 . ILE A 1 315 ? 4.702   -44.675 7.940   1.000 28.909 0 319  ILE A CD1 1 ? 
ATOM   2324 N N   . GLN A 1 316 ? 0.328   -45.286 4.604   1.000 27.324 0 320  GLN A N   1 ? 
ATOM   2325 C CA  . GLN A 1 316 ? -1.064  -45.007 4.237   1.000 27.148 0 320  GLN A CA  1 ? 
ATOM   2326 C C   . GLN A 1 316 ? -2.057  -45.800 5.070   1.000 27.838 0 320  GLN A C   1 ? 
ATOM   2327 O O   . GLN A 1 316 ? -3.149  -45.301 5.377   1.000 28.101 0 320  GLN A O   1 ? 
ATOM   2328 C CB  . GLN A 1 316 ? -1.313  -45.316 2.748   1.000 30.217 0 320  GLN A CB  1 ? 
ATOM   2329 C CG  . GLN A 1 316 ? -2.823  -45.518 2.472   1.000 56.499 0 320  GLN A CG  1 ? 
ATOM   2330 C CD  . GLN A 1 316 ? -3.214  -45.462 1.016   1.000 73.096 0 320  GLN A CD  1 ? 
ATOM   2331 O OE1 . GLN A 1 316 ? -2.536  -46.008 0.151   1.000 81.220 0 320  GLN A OE1 1 ? 
ATOM   2332 N NE2 . GLN A 1 316 ? -4.331  -44.802 0.738   1.000 74.614 0 320  GLN A NE2 1 ? 
ATOM   2333 N N   . SER A 1 317 ? -1.708  -47.036 5.420   1.000 26.603 0 321  SER A N   1 ? 
ATOM   2334 C CA  . SER A 1 317 ? -2.634  -47.873 6.175   1.000 26.872 0 321  SER A CA  1 ? 
ATOM   2335 C C   . SER A 1 317 ? -2.912  -47.335 7.577   1.000 29.680 0 321  SER A C   1 ? 
ATOM   2336 O O   . SER A 1 317 ? -3.834  -47.826 8.245   1.000 32.009 0 321  SER A O   1 ? 
ATOM   2337 C CB  . SER A 1 317 ? -2.099  -49.311 6.256   1.000 25.124 0 321  SER A CB  1 ? 
ATOM   2338 O OG  . SER A 1 317 ? -1.009  -49.441 7.171   1.000 26.598 0 321  SER A OG  1 ? 
ATOM   2339 N N   . LEU A 1 318 ? -2.163  -46.330 8.027   1.000 28.527 0 322  LEU A N   1 ? 
ATOM   2340 C CA  . LEU A 1 318 ? -2.347  -45.751 9.352   1.000 27.514 0 322  LEU A CA  1 ? 
ATOM   2341 C C   . LEU A 1 318 ? -3.143  -44.448 9.330   1.000 30.372 0 322  LEU A C   1 ? 
ATOM   2342 O O   . LEU A 1 318 ? -3.306  -43.821 10.383  1.000 29.148 0 322  LEU A O   1 ? 
ATOM   2343 C CB  . LEU A 1 318 ? -0.981  -45.515 10.002  1.000 25.677 0 322  LEU A CB  1 ? 
ATOM   2344 C CG  . LEU A 1 318 ? -0.006  -46.694 9.963   1.000 24.871 0 322  LEU A CG  1 ? 
ATOM   2345 C CD1 . LEU A 1 318 ? 1.354   -46.280 10.510  1.000 27.724 0 322  LEU A CD1 1 ? 
ATOM   2346 C CD2 . LEU A 1 318 ? -0.593  -47.838 10.774  1.000 29.669 0 322  LEU A CD2 1 ? 
ATOM   2347 N N   . LYS A 1 319 ? -3.668  -44.048 8.163   1.000 31.320 0 323  LYS A N   1 ? 
ATOM   2348 C CA  . LYS A 1 319 ? -4.251  -42.716 7.989   1.000 36.873 0 323  LYS A CA  1 ? 
ATOM   2349 C C   . LYS A 1 319 ? -5.516  -42.500 8.818   1.000 36.354 0 323  LYS A C   1 ? 
ATOM   2350 O O   . LYS A 1 319 ? -5.866  -41.353 9.129   1.000 35.438 0 323  LYS A O   1 ? 
ATOM   2351 C CB  . LYS A 1 319 ? -4.562  -42.491 6.508   1.000 43.176 0 323  LYS A CB  1 ? 
ATOM   2352 C CG  . LYS A 1 319 ? -4.979  -41.082 6.155   1.000 52.025 0 323  LYS A CG  1 ? 
ATOM   2353 C CD  . LYS A 1 319 ? -5.464  -41.001 4.716   1.000 55.707 0 323  LYS A CD  1 ? 
ATOM   2354 C CE  . LYS A 1 319 ? -5.970  -39.606 4.404   1.000 59.131 0 323  LYS A CE  1 ? 
ATOM   2355 N NZ  . LYS A 1 319 ? -6.223  -39.406 2.951   1.000 62.689 0 323  LYS A NZ  1 ? 
ATOM   2356 N N   . GLN A 1 320 ? -6.235  -43.559 9.159   1.000 29.898 0 324  GLN A N   1 ? 
ATOM   2357 C CA  . GLN A 1 320 ? -7.481  -43.381 9.887   1.000 35.102 0 324  GLN A CA  1 ? 
ATOM   2358 C C   . GLN A 1 320 ? -7.295  -43.467 11.393  1.000 33.522 0 324  GLN A C   1 ? 
ATOM   2359 O O   . GLN A 1 320 ? -8.263  -43.268 12.135  1.000 32.257 0 324  GLN A O   1 ? 
ATOM   2360 C CB  . GLN A 1 320 ? -8.513  -44.398 9.397   1.000 40.028 0 324  GLN A CB  1 ? 
ATOM   2361 C CG  . GLN A 1 320 ? -8.741  -44.273 7.892   1.000 45.677 0 324  GLN A CG  1 ? 
ATOM   2362 C CD  . GLN A 1 320 ? -9.970  -45.005 7.402   1.000 55.004 0 324  GLN A CD  1 ? 
ATOM   2363 O OE1 . GLN A 1 320 ? -10.424 -45.976 8.015   1.000 52.838 0 324  GLN A OE1 1 ? 
ATOM   2364 N NE2 . GLN A 1 320 ? -10.519 -44.542 6.284   1.000 60.676 0 324  GLN A NE2 1 ? 
ATOM   2365 N N   . TYR A 1 321 ? -6.072  -43.722 11.853  1.000 30.630 0 325  TYR A N   1 ? 
ATOM   2366 C CA  . TYR A 1 321 ? -5.765  -43.739 13.271  1.000 30.330 0 325  TYR A CA  1 ? 
ATOM   2367 C C   . TYR A 1 321 ? -5.359  -42.349 13.734  1.000 34.457 0 325  TYR A C   1 ? 
ATOM   2368 O O   . TYR A 1 321 ? -4.861  -41.533 12.953  1.000 30.972 0 325  TYR A O   1 ? 
ATOM   2369 C CB  . TYR A 1 321 ? -4.634  -44.725 13.562  1.000 29.367 0 325  TYR A CB  1 ? 
ATOM   2370 C CG  . TYR A 1 321 ? -4.939  -46.152 13.166  1.000 28.603 0 325  TYR A CG  1 ? 
ATOM   2371 C CD1 . TYR A 1 321 ? -6.212  -46.683 13.313  1.000 35.554 0 325  TYR A CD1 1 ? 
ATOM   2372 C CD2 . TYR A 1 321 ? -3.955  -46.968 12.633  1.000 28.698 0 325  TYR A CD2 1 ? 
ATOM   2373 C CE1 . TYR A 1 321 ? -6.491  -47.999 12.945  1.000 32.767 0 325  TYR A CE1 1 ? 
ATOM   2374 C CE2 . TYR A 1 321 ? -4.225  -48.275 12.265  1.000 30.312 0 325  TYR A CE2 1 ? 
ATOM   2375 C CZ  . TYR A 1 321 ? -5.488  -48.787 12.422  1.000 34.612 0 325  TYR A CZ  1 ? 
ATOM   2376 O OH  . TYR A 1 321 ? -5.745  -50.086 12.052  1.000 34.702 0 325  TYR A OH  1 ? 
ATOM   2377 N N   . GLN A 1 322 ? -5.561  -42.090 15.022  1.000 32.051 0 326  GLN A N   1 ? 
ATOM   2378 C CA  . GLN A 1 322 ? -5.066  -40.854 15.607  1.000 34.530 0 326  GLN A CA  1 ? 
ATOM   2379 C C   . GLN A 1 322 ? -3.545  -40.878 15.693  1.000 33.404 0 326  GLN A C   1 ? 
ATOM   2380 O O   . GLN A 1 322 ? -2.959  -41.806 16.259  1.000 32.091 0 326  GLN A O   1 ? 
ATOM   2381 C CB  . GLN A 1 322 ? -5.659  -40.642 16.994  1.000 32.525 0 326  GLN A CB  1 ? 
ATOM   2382 C CG  . GLN A 1 322 ? -5.327  -39.283 17.563  1.000 39.644 0 326  GLN A CG  1 ? 
ATOM   2383 C CD  . GLN A 1 322 ? -5.816  -39.137 18.974  1.000 42.697 0 326  GLN A CD  1 ? 
ATOM   2384 O OE1 . GLN A 1 322 ? -6.566  -39.977 19.463  1.000 42.252 0 326  GLN A OE1 1 ? 
ATOM   2385 N NE2 . GLN A 1 322 ? -5.381  -38.080 19.649  1.000 49.316 0 326  GLN A NE2 1 ? 
ATOM   2386 N N   . TRP A 1 323 ? -2.908  -39.858 15.118  1.000 31.677 0 327  TRP A N   1 ? 
ATOM   2387 C CA  . TRP A 1 323 ? -1.475  -39.630 15.273  1.000 32.433 0 327  TRP A CA  1 ? 
ATOM   2388 C C   . TRP A 1 323 ? -1.302  -38.548 16.330  1.000 34.175 0 327  TRP A C   1 ? 
ATOM   2389 O O   . TRP A 1 323 ? -1.691  -37.394 16.117  1.000 41.363 0 327  TRP A O   1 ? 
ATOM   2390 C CB  . TRP A 1 323 ? -0.824  -39.203 13.960  1.000 35.407 0 327  TRP A CB  1 ? 
ATOM   2391 C CG  . TRP A 1 323 ? -0.675  -40.287 12.949  1.000 35.062 0 327  TRP A CG  1 ? 
ATOM   2392 C CD1 . TRP A 1 323 ? -1.662  -41.086 12.445  1.000 33.154 0 327  TRP A CD1 1 ? 
ATOM   2393 C CD2 . TRP A 1 323 ? 0.535   -40.676 12.289  1.000 31.762 0 327  TRP A CD2 1 ? 
ATOM   2394 N NE1 . TRP A 1 323 ? -1.137  -41.956 11.514  1.000 31.930 0 327  TRP A NE1 1 ? 
ATOM   2395 C CE2 . TRP A 1 323 ? 0.210   -41.724 11.401  1.000 31.048 0 327  TRP A CE2 1 ? 
ATOM   2396 C CE3 . TRP A 1 323 ? 1.866   -40.243 12.366  1.000 30.083 0 327  TRP A CE3 1 ? 
ATOM   2397 C CZ2 . TRP A 1 323 ? 1.168   -42.348 10.598  1.000 28.135 0 327  TRP A CZ2 1 ? 
ATOM   2398 C CZ3 . TRP A 1 323 ? 2.812   -40.860 11.568  1.000 32.549 0 327  TRP A CZ3 1 ? 
ATOM   2399 C CH2 . TRP A 1 323 ? 2.461   -41.900 10.693  1.000 30.396 0 327  TRP A CH2 1 ? 
ATOM   2400 N N   . GLU A 1 324 ? -0.739  -38.919 17.473  1.000 31.330 0 328  GLU A N   1 ? 
ATOM   2401 C CA  . GLU A 1 324 ? -0.460  -37.968 18.538  1.000 30.554 0 328  GLU A CA  1 ? 
ATOM   2402 C C   . GLU A 1 324 ? 1.021   -37.618 18.501  1.000 31.946 0 328  GLU A C   1 ? 
ATOM   2403 O O   . GLU A 1 324 ? 1.879   -38.483 18.719  1.000 29.472 0 328  GLU A O   1 ? 
ATOM   2404 C CB  . GLU A 1 324 ? -0.852  -38.535 19.900  1.000 30.725 0 328  GLU A CB  1 ? 
ATOM   2405 C CG  . GLU A 1 324 ? -0.565  -37.580 21.033  1.000 34.699 0 328  GLU A CG  1 ? 
ATOM   2406 C CD  . GLU A 1 324 ? -1.217  -38.009 22.324  1.000 39.728 0 328  GLU A CD  1 ? 
ATOM   2407 O OE1 . GLU A 1 324 ? -0.524  -38.641 23.147  1.000 35.470 0 328  GLU A OE1 1 ? 
ATOM   2408 O OE2 . GLU A 1 324 ? -2.420  -37.713 22.512  1.000 44.840 0 328  GLU A OE2 1 ? 
ATOM   2409 N N   . ASN A 1 325 ? 1.322   -36.358 18.215  1.000 30.701 0 329  ASN A N   1 ? 
ATOM   2410 C CA  . ASN A 1 325 ? 2.712   -35.944 18.129  1.000 27.651 0 329  ASN A CA  1 ? 
ATOM   2411 C C   . ASN A 1 325 ? 3.362   -35.947 19.506  1.000 31.935 0 329  ASN A C   1 ? 
ATOM   2412 O O   . ASN A 1 325 ? 2.769   -35.504 20.492  1.000 31.743 0 329  ASN A O   1 ? 
ATOM   2413 C CB  . ASN A 1 325 ? 2.809   -34.554 17.501  1.000 30.762 0 329  ASN A CB  1 ? 
ATOM   2414 C CG  . ASN A 1 325 ? 4.238   -34.114 17.300  1.000 33.454 0 329  ASN A CG  1 ? 
ATOM   2415 O OD1 . ASN A 1 325 ? 4.739   -33.234 18.007  1.000 34.007 0 329  ASN A OD1 1 ? 
ATOM   2416 N ND2 . ASN A 1 325 ? 4.915   -34.735 16.337  1.000 32.214 0 329  ASN A ND2 1 ? 
ATOM   2417 N N   . ILE A 1 326 ? 4.584   -36.467 19.573  1.000 28.643 0 330  ILE A N   1 ? 
ATOM   2418 C CA  . ILE A 1 326 ? 5.373   -36.400 20.798  1.000 28.106 0 330  ILE A CA  1 ? 
ATOM   2419 C C   . ILE A 1 326 ? 6.272   -35.174 20.795  1.000 32.172 0 330  ILE A C   1 ? 
ATOM   2420 O O   . ILE A 1 326 ? 6.259   -34.369 21.732  1.000 30.841 0 330  ILE A O   1 ? 
ATOM   2421 C CB  . ILE A 1 326 ? 6.186   -37.705 20.966  1.000 26.185 0 330  ILE A CB  1 ? 
ATOM   2422 C CG1 . ILE A 1 326 ? 5.241   -38.911 21.059  1.000 29.059 0 330  ILE A CG1 1 ? 
ATOM   2423 C CG2 . ILE A 1 326 ? 7.120   -37.609 22.171  1.000 28.977 0 330  ILE A CG2 1 ? 
ATOM   2424 C CD1 . ILE A 1 326 ? 5.895   -40.241 20.691  1.000 25.732 0 330  ILE A CD1 1 ? 
ATOM   2425 N N   . LYS A 1 327 ? 7.042   -35.019 19.723  1.000 27.298 0 331  LYS A N   1 ? 
ATOM   2426 C CA  . LYS A 1 327 ? 7.865   -33.855 19.425  1.000 29.811 0 331  LYS A CA  1 ? 
ATOM   2427 C C   . LYS A 1 327 ? 8.137   -33.897 17.921  1.000 32.299 0 331  LYS A C   1 ? 
ATOM   2428 O O   . LYS A 1 327 ? 7.711   -34.856 17.265  1.000 28.124 0 331  LYS A O   1 ? 
ATOM   2429 C CB  . LYS A 1 327 ? 9.142   -33.880 20.260  1.000 28.651 0 331  LYS A CB  1 ? 
ATOM   2430 C CG  . LYS A 1 327 ? 10.126  -34.966 19.880  1.000 28.977 0 331  LYS A CG  1 ? 
ATOM   2431 C CD  . LYS A 1 327 ? 11.307  -34.915 20.819  1.000 33.791 0 331  LYS A CD  1 ? 
ATOM   2432 C CE  . LYS A 1 327 ? 12.428  -35.787 20.331  1.000 30.898 0 331  LYS A CE  1 ? 
ATOM   2433 N NZ  . LYS A 1 327 ? 13.672  -35.491 21.093  1.000 35.186 0 331  LYS A NZ  1 ? 
ATOM   2434 N N   . PRO A 1 328 ? 8.795   -32.898 17.327  1.000 35.783 0 332  PRO A N   1 ? 
ATOM   2435 C CA  . PRO A 1 328 ? 9.014   -32.935 15.873  1.000 36.489 0 332  PRO A CA  1 ? 
ATOM   2436 C C   . PRO A 1 328 ? 9.624   -34.250 15.403  1.000 29.696 0 332  PRO A C   1 ? 
ATOM   2437 O O   . PRO A 1 328 ? 10.644  -34.710 15.925  1.000 28.124 0 332  PRO A O   1 ? 
ATOM   2438 C CB  . PRO A 1 328 ? 9.959   -31.753 15.640  1.000 40.036 0 332  PRO A CB  1 ? 
ATOM   2439 C CG  . PRO A 1 328 ? 9.530   -30.768 16.663  1.000 40.584 0 332  PRO A CG  1 ? 
ATOM   2440 C CD  . PRO A 1 328 ? 9.157   -31.581 17.884  1.000 40.636 0 332  PRO A CD  1 ? 
ATOM   2441 N N   . GLN A 1 329 ? 8.960   -34.866 14.420  1.000 31.233 0 333  GLN A N   1 ? 
ATOM   2442 C CA  . GLN A 1 329 ? 9.381   -36.102 13.765  1.000 28.653 0 333  GLN A CA  1 ? 
ATOM   2443 C C   . GLN A 1 329 ? 9.314   -37.316 14.684  1.000 28.882 0 333  GLN A C   1 ? 
ATOM   2444 O O   . GLN A 1 329 ? 9.938   -38.340 14.399  1.000 26.185 0 333  GLN A O   1 ? 
ATOM   2445 C CB  . GLN A 1 329 ? 10.790  -35.968 13.170  1.000 28.546 0 333  GLN A CB  1 ? 
ATOM   2446 C CG  . GLN A 1 329 ? 10.839  -35.162 11.873  1.000 32.612 0 333  GLN A CG  1 ? 
ATOM   2447 C CD  . GLN A 1 329 ? 10.572  -33.689 12.101  1.000 39.786 0 333  GLN A CD  1 ? 
ATOM   2448 O OE1 . GLN A 1 329 ? 11.356  -33.001 12.754  1.000 38.768 0 333  GLN A OE1 1 ? 
ATOM   2449 N NE2 . GLN A 1 329 ? 9.451   -33.201 11.579  1.000 46.274 0 333  GLN A NE2 1 ? 
ATOM   2450 N N   . VAL A 1 330 ? 8.569   -37.240 15.788  1.000 25.535 0 334  VAL A N   1 ? 
ATOM   2451 C CA  . VAL A 1 330 ? 8.344   -38.388 16.661  1.000 25.240 0 334  VAL A CA  1 ? 
ATOM   2452 C C   . VAL A 1 330 ? 6.853   -38.438 16.965  1.000 24.074 0 334  VAL A C   1 ? 
ATOM   2453 O O   . VAL A 1 330 ? 6.312   -37.509 17.575  1.000 25.827 0 334  VAL A O   1 ? 
ATOM   2454 C CB  . VAL A 1 330 ? 9.165   -38.312 17.960  1.000 23.924 0 334  VAL A CB  1 ? 
ATOM   2455 C CG1 . VAL A 1 330 ? 9.045   -39.616 18.729  1.000 25.487 0 334  VAL A CG1 1 ? 
ATOM   2456 C CG2 . VAL A 1 330 ? 10.639  -38.028 17.651  1.000 24.174 0 334  VAL A CG2 1 ? 
ATOM   2457 N N   . ASP A 1 331 ? 6.183   -39.502 16.526  1.000 22.782 0 335  ASP A N   1 ? 
ATOM   2458 C CA  . ASP A 1 331 ? 4.736   -39.579 16.661  1.000 24.369 0 335  ASP A CA  1 ? 
ATOM   2459 C C   . ASP A 1 331 ? 4.313   -40.910 17.255  1.000 23.784 0 335  ASP A C   1 ? 
ATOM   2460 O O   . ASP A 1 331 ? 4.937   -41.945 17.017  1.000 24.700 0 335  ASP A O   1 ? 
ATOM   2461 C CB  . ASP A 1 331 ? 4.018   -39.411 15.310  1.000 25.808 0 335  ASP A CB  1 ? 
ATOM   2462 C CG  . ASP A 1 331 ? 4.223   -38.042 14.714  1.000 30.490 0 335  ASP A CG  1 ? 
ATOM   2463 O OD1 . ASP A 1 331 ? 3.559   -37.089 15.174  1.000 30.822 0 335  ASP A OD1 1 ? 
ATOM   2464 O OD2 . ASP A 1 331 ? 5.052   -37.918 13.791  1.000 30.920 0 335  ASP A OD2 1 ? 
ATOM   2465 N N   . HIS A 1 332 ? 3.225   -40.861 18.014  1.000 25.150 0 336  HIS A N   1 ? 
ATOM   2466 C CA  . HIS A 1 332 ? 2.469   -42.048 18.376  1.000 25.887 0 336  HIS A CA  1 ? 
ATOM   2467 C C   . HIS A 1 332 ? 1.372   -42.281 17.351  1.000 30.691 0 336  HIS A C   1 ? 
ATOM   2468 O O   . HIS A 1 332 ? 0.657   -41.350 16.979  1.000 30.838 0 336  HIS A O   1 ? 
ATOM   2469 C CB  . HIS A 1 332 ? 1.811   -41.888 19.746  1.000 27.230 0 336  HIS A CB  1 ? 
ATOM   2470 C CG  . HIS A 1 332 ? 2.643   -42.385 20.882  1.000 26.601 0 336  HIS A CG  1 ? 
ATOM   2471 N ND1 . HIS A 1 332 ? 2.674   -41.753 22.105  1.000 28.540 0 336  HIS A ND1 1 ? 
ATOM   2472 C CD2 . HIS A 1 332 ? 3.454   -43.462 20.992  1.000 26.935 0 336  HIS A CD2 1 ? 
ATOM   2473 C CE1 . HIS A 1 332 ? 3.478   -42.416 22.919  1.000 27.580 0 336  HIS A CE1 1 ? 
ATOM   2474 N NE2 . HIS A 1 332 ? 3.957   -43.460 22.269  1.000 26.416 0 336  HIS A NE2 1 ? 
ATOM   2475 N N   . VAL A 1 333 ? 1.227   -43.528 16.917  1.000 24.203 0 337  VAL A N   1 ? 
ATOM   2476 C CA  . VAL A 1 333 ? 0.043   -43.968 16.185  1.000 24.371 0 337  VAL A CA  1 ? 
ATOM   2477 C C   . VAL A 1 333 ? -0.779  -44.808 17.148  1.000 27.116 0 337  VAL A C   1 ? 
ATOM   2478 O O   . VAL A 1 333 ? -0.287  -45.817 17.672  1.000 26.266 0 337  VAL A O   1 ? 
ATOM   2479 C CB  . VAL A 1 333 ? 0.413   -44.763 14.925  1.000 28.569 0 337  VAL A CB  1 ? 
ATOM   2480 C CG1 . VAL A 1 333 ? -0.847  -45.221 14.187  1.000 28.724 0 337  VAL A CG1 1 ? 
ATOM   2481 C CG2 . VAL A 1 333 ? 1.294   -43.928 14.029  1.000 30.756 0 337  VAL A CG2 1 ? 
ATOM   2482 N N   . ILE A 1 334 ? -2.018  -44.388 17.389  1.000 27.087 0 338  ILE A N   1 ? 
ATOM   2483 C CA  . ILE A 1 334 ? -2.873  -44.993 18.402  1.000 30.348 0 338  ILE A CA  1 ? 
ATOM   2484 C C   . ILE A 1 334 ? -3.863  -45.916 17.707  1.000 30.906 0 338  ILE A C   1 ? 
ATOM   2485 O O   . ILE A 1 334 ? -4.699  -45.460 16.916  1.000 31.917 0 338  ILE A O   1 ? 
ATOM   2486 C CB  . ILE A 1 334 ? -3.606  -43.924 19.225  1.000 33.801 0 338  ILE A CB  1 ? 
ATOM   2487 C CG1 . ILE A 1 334 ? -2.599  -42.984 19.899  1.000 32.936 0 338  ILE A CG1 1 ? 
ATOM   2488 C CG2 . ILE A 1 334 ? -4.520  -44.586 20.249  1.000 34.959 0 338  ILE A CG2 1 ? 
ATOM   2489 C CD1 . ILE A 1 334 ? -3.222  -41.698 20.430  1.000 32.370 0 338  ILE A CD1 1 ? 
ATOM   2490 N N   . PHE A 1 335 ? -3.765  -47.213 17.994  1.000 31.499 0 339  PHE A N   1 ? 
ATOM   2491 C CA  . PHE A 1 335 ? -4.655  -48.202 17.404  1.000 30.733 0 339  PHE A CA  1 ? 
ATOM   2492 C C   . PHE A 1 335 ? -5.978  -48.270 18.166  1.000 32.483 0 339  PHE A C   1 ? 
ATOM   2493 O O   . PHE A 1 335 ? -6.084  -47.800 19.303  1.000 32.209 0 339  PHE A O   1 ? 
ATOM   2494 C CB  . PHE A 1 335 ? -3.969  -49.568 17.382  1.000 29.838 0 339  PHE A CB  1 ? 
ATOM   2495 C CG  . PHE A 1 335 ? -2.969  -49.724 16.262  1.000 32.433 0 339  PHE A CG  1 ? 
ATOM   2496 C CD1 . PHE A 1 335 ? -1.764  -49.043 16.291  1.000 34.862 0 339  PHE A CD1 1 ? 
ATOM   2497 C CD2 . PHE A 1 335 ? -3.243  -50.547 15.179  1.000 32.062 0 339  PHE A CD2 1 ? 
ATOM   2498 C CE1 . PHE A 1 335 ? -0.843  -49.188 15.258  1.000 31.951 0 339  PHE A CE1 1 ? 
ATOM   2499 C CE2 . PHE A 1 335 ? -2.332  -50.694 14.150  1.000 32.820 0 339  PHE A CE2 1 ? 
ATOM   2500 C CZ  . PHE A 1 335 ? -1.133  -50.014 14.189  1.000 31.541 0 339  PHE A CZ  1 ? 
ATOM   2501 N N   . PRO A 1 336 ? -7.016  -48.843 17.553  1.000 33.938 0 340  PRO A N   1 ? 
ATOM   2502 C CA  . PRO A 1 336 ? -8.342  -48.820 18.198  1.000 34.702 0 340  PRO A CA  1 ? 
ATOM   2503 C C   . PRO A 1 336 ? -8.399  -49.537 19.536  1.000 34.852 0 340  PRO A C   1 ? 
ATOM   2504 O O   . PRO A 1 336 ? -9.239  -49.184 20.373  1.000 38.260 0 340  PRO A O   1 ? 
ATOM   2505 C CB  . PRO A 1 336 ? -9.241  -49.497 17.158  1.000 34.233 0 340  PRO A CB  1 ? 
ATOM   2506 C CG  . PRO A 1 336 ? -8.559  -49.236 15.854  1.000 32.678 0 340  PRO A CG  1 ? 
ATOM   2507 C CD  . PRO A 1 336 ? -7.089  -49.316 16.157  1.000 30.138 0 340  PRO A CD  1 ? 
ATOM   2508 N N   . ASP A 1 337 ? -7.545  -50.537 19.767  1.000 34.444 0 341  ASP A N   1 ? 
ATOM   2509 C CA  . ASP A 1 337 ? -7.512  -51.197 21.069  1.000 37.860 0 341  ASP A CA  1 ? 
ATOM   2510 C C   . ASP A 1 337 ? -6.649  -50.455 22.083  1.000 35.744 0 341  ASP A C   1 ? 
ATOM   2511 O O   . ASP A 1 337 ? -6.463  -50.954 23.197  1.000 37.447 0 341  ASP A O   1 ? 
ATOM   2512 C CB  . ASP A 1 337 ? -7.027  -52.646 20.925  1.000 39.360 0 341  ASP A CB  1 ? 
ATOM   2513 C CG  . ASP A 1 337 ? -5.558  -52.752 20.546  1.000 45.363 0 341  ASP A CG  1 ? 
ATOM   2514 O OD1 . ASP A 1 337 ? -4.952  -51.743 20.121  1.000 37.515 0 341  ASP A OD1 1 ? 
ATOM   2515 O OD2 . ASP A 1 337 ? -5.002  -53.865 20.668  1.000 47.774 0 341  ASP A OD2 1 ? 
ATOM   2516 N N   . GLY A 1 338 ? -6.120  -49.287 21.727  1.000 34.920 0 342  GLY A N   1 ? 
ATOM   2517 C CA  . GLY A 1 338 ? -5.326  -48.497 22.636  1.000 33.991 0 342  GLY A CA  1 ? 
ATOM   2518 C C   . GLY A 1 338 ? -3.834  -48.709 22.526  1.000 32.491 0 342  GLY A C   1 ? 
ATOM   2519 O O   . GLY A 1 338 ? -3.068  -47.906 23.079  1.000 32.893 0 342  GLY A O   1 ? 
ATOM   2520 N N   . LYS A 1 339 ? -3.394  -49.759 21.833  1.000 27.390 0 343  LYS A N   1 ? 
ATOM   2521 C CA  . LYS A 1 339 ? -1.966  -49.974 21.636  1.000 25.840 0 343  LYS A CA  1 ? 
ATOM   2522 C C   . LYS A 1 339 ? -1.379  -48.837 20.811  1.000 29.925 0 343  LYS A C   1 ? 
ATOM   2523 O O   . LYS A 1 339 ? -1.995  -48.368 19.851  1.000 31.925 0 343  LYS A O   1 ? 
ATOM   2524 C CB  . LYS A 1 339 ? -1.729  -51.315 20.935  1.000 31.327 0 343  LYS A CB  1 ? 
ATOM   2525 C CG  . LYS A 1 339 ? -0.257  -51.725 20.793  1.000 28.669 0 343  LYS A CG  1 ? 
ATOM   2526 C CD  . LYS A 1 339 ? 0.386   -51.283 19.467  1.000 33.722 0 343  LYS A CD  1 ? 
ATOM   2527 C CE  . LYS A 1 339 ? -0.366  -51.814 18.258  1.000 36.728 0 343  LYS A CE  1 ? 
ATOM   2528 N NZ  . LYS A 1 339 ? -0.179  -53.277 18.090  1.000 36.733 0 343  LYS A NZ  1 ? 
ATOM   2529 N N   . ARG A 1 340 ? -0.175  -48.396 21.185  1.000 25.832 0 344  ARG A N   1 ? 
ATOM   2530 C CA  . ARG A 1 340 ? 0.526   -47.332 20.479  1.000 24.861 0 344  ARG A CA  1 ? 
ATOM   2531 C C   . ARG A 1 340 ? 1.830   -47.857 19.899  1.000 26.566 0 344  ARG A C   1 ? 
ATOM   2532 O O   . ARG A 1 340 ? 2.529   -48.652 20.536  1.000 29.919 0 344  ARG A O   1 ? 
ATOM   2533 C CB  . ARG A 1 340 ? 0.837   -46.143 21.405  1.000 26.922 0 344  ARG A CB  1 ? 
ATOM   2534 C CG  . ARG A 1 340 ? -0.383  -45.456 21.971  1.000 29.467 0 344  ARG A CG  1 ? 
ATOM   2535 C CD  . ARG A 1 340 ? -0.003  -44.261 22.832  1.000 32.780 0 344  ARG A CD  1 ? 
ATOM   2536 N NE  . ARG A 1 340 ? -1.196  -43.620 23.363  1.000 31.362 0 344  ARG A NE  1 ? 
ATOM   2537 C CZ  . ARG A 1 340 ? -1.350  -42.309 23.512  1.000 35.388 0 344  ARG A CZ  1 ? 
ATOM   2538 N NH1 . ARG A 1 340 ? -0.373  -41.477 23.174  1.000 32.767 0 344  ARG A NH1 1 ? 
ATOM   2539 N NH2 . ARG A 1 340 ? -2.490  -41.827 23.995  1.000 33.215 0 344  ARG A NH2 1 ? 
ATOM   2540 N N   . ILE A 1 341 ? 2.170   -47.409 18.694  1.000 22.592 0 345  ILE A N   1 ? 
ATOM   2541 C CA  . ILE A 1 341 ? 3.532   -47.574 18.202  1.000 23.226 0 345  ILE A CA  1 ? 
ATOM   2542 C C   . ILE A 1 341 ? 4.152   -46.193 18.043  1.000 23.508 0 345  ILE A C   1 ? 
ATOM   2543 O O   . ILE A 1 341 ? 3.457   -45.183 17.872  1.000 26.782 0 345  ILE A O   1 ? 
ATOM   2544 C CB  . ILE A 1 341 ? 3.613   -48.368 16.883  1.000 28.643 0 345  ILE A CB  1 ? 
ATOM   2545 C CG1 . ILE A 1 341 ? 2.821   -47.675 15.787  1.000 32.535 0 345  ILE A CG1 1 ? 
ATOM   2546 C CG2 . ILE A 1 341 ? 3.114   -49.794 17.080  1.000 29.825 0 345  ILE A CG2 1 ? 
ATOM   2547 C CD1 . ILE A 1 341 ? 3.107   -48.231 14.410  1.000 40.894 0 345  ILE A CD1 1 ? 
ATOM   2548 N N   . ILE A 1 342 ? 5.474   -46.149 18.159  1.000 21.608 0 346  ILE A N   1 ? 
ATOM   2549 C CA  . ILE A 1 342 ? 6.243   -44.936 17.943  1.000 21.824 0 346  ILE A CA  1 ? 
ATOM   2550 C C   . ILE A 1 342 ? 6.813   -45.013 16.541  1.000 23.598 0 346  ILE A C   1 ? 
ATOM   2551 O O   . ILE A 1 342 ? 7.588   -45.924 16.232  1.000 24.950 0 346  ILE A O   1 ? 
ATOM   2552 C CB  . ILE A 1 342 ? 7.367   -44.783 18.977  1.000 21.697 0 346  ILE A CB  1 ? 
ATOM   2553 C CG1 . ILE A 1 342 ? 6.773   -44.642 20.386  1.000 23.684 0 346  ILE A CG1 1 ? 
ATOM   2554 C CG2 . ILE A 1 342 ? 8.256   -43.590 18.601  1.000 26.040 0 346  ILE A CG2 1 ? 
ATOM   2555 C CD1 . ILE A 1 342 ? 7.812   -44.818 21.502  1.000 24.206 0 346  ILE A CD1 1 ? 
ATOM   2556 N N   . ILE A 1 343 ? 6.416   -44.080 15.684  1.000 22.171 0 347  ILE A N   1 ? 
ATOM   2557 C CA  . ILE A 1 343 ? 6.930   -44.004 14.320  1.000 20.258 0 347  ILE A CA  1 ? 
ATOM   2558 C C   . ILE A 1 343 ? 7.844   -42.790 14.236  1.000 21.455 0 347  ILE A C   1 ? 
ATOM   2559 O O   . ILE A 1 343 ? 7.489   -41.704 14.713  1.000 23.882 0 347  ILE A O   1 ? 
ATOM   2560 C CB  . ILE A 1 343 ? 5.786   -43.927 13.292  1.000 26.606 0 347  ILE A CB  1 ? 
ATOM   2561 C CG1 . ILE A 1 343 ? 6.329   -43.590 11.903  1.000 28.264 0 347  ILE A CG1 1 ? 
ATOM   2562 C CG2 . ILE A 1 343 ? 4.768   -42.886 13.698  1.000 42.495 0 347  ILE A CG2 1 ? 
ATOM   2563 C CD1 . ILE A 1 343 ? 7.040   -44.731 11.242  1.000 43.060 0 347  ILE A CD1 1 ? 
ATOM   2564 N N   . LEU A 1 344 ? 9.025   -42.970 13.649  1.000 20.979 0 348  LEU A N   1 ? 
ATOM   2565 C CA  . LEU A 1 344 ? 10.001  -41.892 13.558  1.000 20.789 0 348  LEU A CA  1 ? 
ATOM   2566 C C   . LEU A 1 344 ? 9.958   -41.249 12.174  1.000 25.266 0 348  LEU A C   1 ? 
ATOM   2567 O O   . LEU A 1 344 ? 9.994   -41.949 11.157  1.000 22.508 0 348  LEU A O   1 ? 
ATOM   2568 C CB  . LEU A 1 344 ? 11.405  -42.414 13.864  1.000 19.831 0 348  LEU A CB  1 ? 
ATOM   2569 C CG  . LEU A 1 344 ? 11.512  -43.073 15.247  1.000 20.695 0 348  LEU A CG  1 ? 
ATOM   2570 C CD1 . LEU A 1 344 ? 12.975  -43.387 15.585  1.000 20.955 0 348  LEU A CD1 1 ? 
ATOM   2571 C CD2 . LEU A 1 344 ? 10.882  -42.196 16.336  1.000 22.342 0 348  LEU A CD2 1 ? 
ATOM   2572 N N   . ALA A 1 345 ? 9.871   -39.915 12.151  1.000 23.777 0 349  ALA A N   1 ? 
ATOM   2573 C CA  . ALA A 1 345 ? 9.939   -39.108 10.925  1.000 24.603 0 349  ALA A CA  1 ? 
ATOM   2574 C C   . ALA A 1 345 ? 8.918   -39.545 9.872   1.000 25.216 0 349  ALA A C   1 ? 
ATOM   2575 O O   . ALA A 1 345 ? 9.177   -39.456 8.668   1.000 23.816 0 349  ALA A O   1 ? 
ATOM   2576 C CB  . ALA A 1 345 ? 11.360  -39.124 10.342  1.000 22.674 0 349  ALA A CB  1 ? 
ATOM   2577 N N   . GLU A 1 346 ? 7.739   -40.000 10.315  1.000 24.061 0 350  GLU A N   1 ? 
ATOM   2578 C CA  . GLU A 1 346 ? 6.677   -40.462 9.409   1.000 24.766 0 350  GLU A CA  1 ? 
ATOM   2579 C C   . GLU A 1 346 ? 7.194   -41.493 8.403   1.000 23.026 0 350  GLU A C   1 ? 
ATOM   2580 O O   . GLU A 1 346 ? 6.703   -41.590 7.277   1.000 27.130 0 350  GLU A O   1 ? 
ATOM   2581 C CB  . GLU A 1 346 ? 6.016   -39.283 8.680   1.000 26.061 0 350  GLU A CB  1 ? 
ATOM   2582 C CG  . GLU A 1 346 ? 5.345   -38.290 9.617   1.000 30.188 0 350  GLU A CG  1 ? 
ATOM   2583 C CD  . GLU A 1 346 ? 5.007   -36.964 8.940   1.000 37.902 0 350  GLU A CD  1 ? 
ATOM   2584 O OE1 . GLU A 1 346 ? 4.949   -35.941 9.650   1.000 40.210 0 350  GLU A OE1 1 ? 
ATOM   2585 O OE2 . GLU A 1 346 ? 4.801   -36.944 7.708   1.000 43.100 0 350  GLU A OE2 1 ? 
ATOM   2586 N N   . GLY A 1 347 ? 8.188   -42.282 8.805   1.000 21.084 0 351  GLY A N   1 ? 
ATOM   2587 C CA  . GLY A 1 347 ? 8.753   -43.286 7.932   1.000 21.387 0 351  GLY A CA  1 ? 
ATOM   2588 C C   . GLY A 1 347 ? 9.811   -42.791 6.969   1.000 21.663 0 351  GLY A C   1 ? 
ATOM   2589 O O   . GLY A 1 347 ? 10.338  -43.596 6.193   1.000 22.774 0 351  GLY A O   1 ? 
ATOM   2590 N N   . ARG A 1 348 ? 10.137  -41.503 6.983   1.000 22.669 0 352  ARG A N   1 ? 
ATOM   2591 C CA  . ARG A 1 348 ? 11.227  -40.985 6.168   1.000 22.405 0 352  ARG A CA  1 ? 
ATOM   2592 C C   . ARG A 1 348 ? 12.576  -41.305 6.826   1.000 22.050 0 352  ARG A C   1 ? 
ATOM   2593 O O   . ARG A 1 348 ? 12.650  -41.610 8.019   1.000 22.421 0 352  ARG A O   1 ? 
ATOM   2594 C CB  . ARG A 1 348 ? 11.069  -39.471 5.975   1.000 23.232 0 352  ARG A CB  1 ? 
ATOM   2595 C CG  . ARG A 1 348 ? 10.068  -39.046 4.872   1.000 21.558 0 352  ARG A CG  1 ? 
ATOM   2596 C CD  . ARG A 1 348 ? 8.606   -39.374 5.229   1.000 23.411 0 352  ARG A CD  1 ? 
ATOM   2597 N NE  . ARG A 1 348 ? 7.699   -38.874 4.192   1.000 24.777 0 352  ARG A NE  1 ? 
ATOM   2598 C CZ  . ARG A 1 348 ? 6.402   -39.166 4.112   1.000 28.043 0 352  ARG A CZ  1 ? 
ATOM   2599 N NH1 . ARG A 1 348 ? 5.835   -39.967 5.007   1.000 29.322 0 352  ARG A NH1 1 ? 
ATOM   2600 N NH2 . ARG A 1 348 ? 5.669   -38.650 3.127   1.000 28.014 0 352  ARG A NH2 1 ? 
ATOM   2601 N N   . LEU A 1 349 ? 13.647  -41.238 6.024   1.000 19.802 0 353  LEU A N   1 ? 
ATOM   2602 C CA  . LEU A 1 349 ? 15.017  -41.539 6.465   1.000 21.692 0 353  LEU A CA  1 ? 
ATOM   2603 C C   . LEU A 1 349 ? 15.295  -41.091 7.900   1.000 21.608 0 353  LEU A C   1 ? 
ATOM   2604 O O   . LEU A 1 349 ? 15.337  -39.888 8.173   1.000 24.637 0 353  LEU A O   1 ? 
ATOM   2605 C CB  . LEU A 1 349 ? 16.032  -40.861 5.525   1.000 25.577 0 353  LEU A CB  1 ? 
ATOM   2606 C CG  . LEU A 1 349 ? 16.301  -41.471 4.153   1.000 31.372 0 353  LEU A CG  1 ? 
ATOM   2607 C CD1 . LEU A 1 349 ? 16.785  -40.424 3.155   1.000 27.116 0 353  LEU A CD1 1 ? 
ATOM   2608 C CD2 . LEU A 1 349 ? 17.342  -42.550 4.273   1.000 29.538 0 353  LEU A CD2 1 ? 
ATOM   2609 N N   . VAL A 1 350 ? 15.499  -42.042 8.823   1.000 20.958 0 354  VAL A N   1 ? 
ATOM   2610 C CA  . VAL A 1 350 ? 15.486  -41.702 10.247  1.000 20.629 0 354  VAL A CA  1 ? 
ATOM   2611 C C   . VAL A 1 350 ? 16.765  -40.971 10.648  1.000 21.103 0 354  VAL A C   1 ? 
ATOM   2612 O O   . VAL A 1 350 ? 16.738  -40.085 11.512  1.000 22.500 0 354  VAL A O   1 ? 
ATOM   2613 C CB  . VAL A 1 350 ? 15.256  -42.968 11.106  1.000 20.079 0 354  VAL A CB  1 ? 
ATOM   2614 C CG1 . VAL A 1 350 ? 16.404  -43.974 10.939  1.000 21.295 0 354  VAL A CG1 1 ? 
ATOM   2615 C CG2 . VAL A 1 350 ? 15.091  -42.611 12.575  1.000 22.271 0 354  VAL A CG2 1 ? 
ATOM   2616 N N   . ASN A 1 351 ? 17.907  -41.332 10.047  1.000 19.142 0 355  ASN A N   1 ? 
ATOM   2617 C CA  . ASN A 1 351 ? 19.159  -40.724 10.480  1.000 19.605 0 355  ASN A CA  1 ? 
ATOM   2618 C C   . ASN A 1 351 ? 19.230  -39.256 10.075  1.000 24.163 0 355  ASN A C   1 ? 
ATOM   2619 O O   . ASN A 1 351 ? 19.809  -38.442 10.803  1.000 25.895 0 355  ASN A O   1 ? 
ATOM   2620 C CB  . ASN A 1 351 ? 20.359  -41.522 9.941   1.000 19.418 0 355  ASN A CB  1 ? 
ATOM   2621 C CG  . ASN A 1 351 ? 20.406  -41.602 8.418   1.000 25.490 0 355  ASN A CG  1 ? 
ATOM   2622 O OD1 . ASN A 1 351 ? 19.381  -41.682 7.739   1.000 21.334 0 355  ASN A OD1 1 ? 
ATOM   2623 N ND2 . ASN A 1 351 ? 21.622  -41.632 7.875   1.000 25.498 0 355  ASN A ND2 1 ? 
ATOM   2624 N N   . LEU A 1 352 ? 18.589  -38.890 8.969   1.000 21.268 0 356  LEU A N   1 ? 
ATOM   2625 C CA  . LEU A 1 352 ? 18.535  -37.494 8.543   1.000 20.763 0 356  LEU A CA  1 ? 
ATOM   2626 C C   . LEU A 1 352 ? 17.295  -36.759 9.033   1.000 24.685 0 356  LEU A C   1 ? 
ATOM   2627 O O   . LEU A 1 352 ? 17.315  -35.525 9.116   1.000 25.464 0 356  LEU A O   1 ? 
ATOM   2628 C CB  . LEU A 1 352 ? 18.604  -37.420 7.011   1.000 25.832 0 356  LEU A CB  1 ? 
ATOM   2629 C CG  . LEU A 1 352 ? 19.980  -37.787 6.438   1.000 28.461 0 356  LEU A CG  1 ? 
ATOM   2630 C CD1 . LEU A 1 352 ? 19.856  -38.637 5.191   1.000 30.204 0 356  LEU A CD1 1 ? 
ATOM   2631 C CD2 . LEU A 1 352 ? 20.794  -36.538 6.137   1.000 28.251 0 356  LEU A CD2 1 ? 
ATOM   2632 N N   . GLY A 1 353 ? 16.224  -37.475 9.364   1.000 21.871 0 357  GLY A N   1 ? 
ATOM   2633 C CA  . GLY A 1 353 ? 15.003  -36.830 9.799   1.000 22.637 0 357  GLY A CA  1 ? 
ATOM   2634 C C   . GLY A 1 353 ? 14.944  -36.549 11.286  1.000 26.269 0 357  GLY A C   1 ? 
ATOM   2635 O O   . GLY A 1 353 ? 14.385  -35.528 11.707  1.000 27.553 0 357  GLY A O   1 ? 
ATOM   2636 N N   . CYS A 1 354 ? 15.494  -37.462 12.089  1.000 21.905 0 358  CYS A N   1 ? 
ATOM   2637 C CA  . CYS A 1 354 ? 15.537  -37.331 13.540  1.000 21.916 0 358  CYS A CA  1 ? 
ATOM   2638 C C   . CYS A 1 354 ? 16.912  -36.952 14.068  1.000 24.134 0 358  CYS A C   1 ? 
ATOM   2639 O O   . CYS A 1 354 ? 17.033  -36.646 15.260  1.000 24.966 0 358  CYS A O   1 ? 
ATOM   2640 C CB  . CYS A 1 354 ? 15.085  -38.638 14.206  1.000 23.624 0 358  CYS A CB  1 ? 
ATOM   2641 S SG  . CYS A 1 354 ? 13.346  -39.030 13.880  1.000 24.919 0 358  CYS A SG  1 ? 
ATOM   2642 N N   . ALA A 1 355 ? 17.939  -36.975 13.220  1.000 24.311 0 359  ALA A N   1 ? 
ATOM   2643 C CA  . ALA A 1 355 ? 19.273  -36.504 13.572  1.000 24.045 0 359  ALA A CA  1 ? 
ATOM   2644 C C   . ALA A 1 355 ? 19.834  -35.728 12.384  1.000 25.543 0 359  ALA A C   1 ? 
ATOM   2645 O O   . ALA A 1 355 ? 19.064  -35.148 11.615  1.000 28.493 0 359  ALA A O   1 ? 
ATOM   2646 C CB  . ALA A 1 355 ? 20.178  -37.675 13.963  1.000 24.321 0 359  ALA A CB  1 ? 
ATOM   2647 N N   . THR A 1 356 ? 21.157  -35.729 12.201  1.000 32.696 0 360  THR A N   1 ? 
ATOM   2648 C CA  . THR A 1 356 ? 21.804  -34.885 11.199  1.000 35.965 0 360  THR A CA  1 ? 
ATOM   2649 C C   . THR A 1 356 ? 22.496  -35.680 10.084  1.000 40.273 0 360  THR A C   1 ? 
ATOM   2650 O O   . THR A 1 356 ? 23.344  -35.124 9.375   1.000 40.302 0 360  THR A O   1 ? 
ATOM   2651 C CB  . THR A 1 356 ? 22.821  -33.960 11.873  1.000 32.775 0 360  THR A CB  1 ? 
ATOM   2652 O OG1 . THR A 1 356 ? 23.827  -34.766 12.507  1.000 43.897 0 360  THR A OG1 1 ? 
ATOM   2653 C CG2 . THR A 1 356 ? 22.148  -33.063 12.910  1.000 37.970 0 360  THR A CG2 1 ? 
ATOM   2654 N N   . GLY A 1 357 ? 22.165  -36.961 9.907   1.000 33.538 0 361  GLY A N   1 ? 
ATOM   2655 C CA  . GLY A 1 357 ? 22.824  -37.760 8.885   1.000 34.549 0 361  GLY A CA  1 ? 
ATOM   2656 C C   . GLY A 1 357 ? 24.230  -38.168 9.289   1.000 35.428 0 361  GLY A C   1 ? 
ATOM   2657 O O   . GLY A 1 357 ? 24.637  -38.024 10.445  1.000 36.407 0 361  GLY A O   1 ? 
ATOM   2658 N N   . HIS A 1 358 ? 24.987  -38.686 8.312   1.000 35.394 0 362  HIS A N   1 ? 
ATOM   2659 C CA  . HIS A 1 358 ? 26.328  -39.192 8.601   1.000 28.119 0 362  HIS A CA  1 ? 
ATOM   2660 C C   . HIS A 1 358 ? 27.275  -38.067 9.019   1.000 25.877 0 362  HIS A C   1 ? 
ATOM   2661 O O   . HIS A 1 358 ? 27.122  -36.910 8.603   1.000 27.409 0 362  HIS A O   1 ? 
ATOM   2662 C CB  . HIS A 1 358 ? 26.956  -39.885 7.393   1.000 27.122 0 362  HIS A CB  1 ? 
ATOM   2663 C CG  . HIS A 1 358 ? 26.195  -41.069 6.884   1.000 24.563 0 362  HIS A CG  1 ? 
ATOM   2664 N ND1 . HIS A 1 358 ? 25.207  -41.708 7.611   1.000 28.043 0 362  HIS A ND1 1 ? 
ATOM   2665 C CD2 . HIS A 1 358 ? 26.281  -41.726 5.705   1.000 26.577 0 362  HIS A CD2 1 ? 
ATOM   2666 C CE1 . HIS A 1 358 ? 24.717  -42.707 6.896   1.000 26.745 0 362  HIS A CE1 1 ? 
ATOM   2667 N NE2 . HIS A 1 358 ? 25.342  -42.733 5.729   1.000 27.295 0 362  HIS A NE2 1 ? 
ATOM   2668 N N   . PRO A 1 359 ? 28.287  -38.399 9.804   1.000 29.196 0 363  PRO A N   1 ? 
ATOM   2669 C CA  . PRO A 1 359 ? 29.290  -37.412 10.165  1.000 28.946 0 363  PRO A CA  1 ? 
ATOM   2670 C C   . PRO A 1 359 ? 30.134  -37.030 8.964   1.000 22.455 0 363  PRO A C   1 ? 
ATOM   2671 O O   . PRO A 1 359 ? 30.185  -37.712 7.931   1.000 21.205 0 363  PRO A O   1 ? 
ATOM   2672 C CB  . PRO A 1 359 ? 30.136  -38.118 11.230  1.000 36.849 0 363  PRO A CB  1 ? 
ATOM   2673 C CG  . PRO A 1 359 ? 29.394  -39.368 11.581  1.000 37.828 0 363  PRO A CG  1 ? 
ATOM   2674 C CD  . PRO A 1 359 ? 28.553  -39.715 10.407  1.000 31.535 0 363  PRO A CD  1 ? 
ATOM   2675 N N   . SER A 1 360 ? 30.840  -35.928 9.155   1.000 21.597 0 364  SER A N   1 ? 
ATOM   2676 C CA  . SER A 1 360 ? 31.504  -35.251 8.052   1.000 21.545 0 364  SER A CA  1 ? 
ATOM   2677 C C   . SER A 1 360 ? 32.551  -36.130 7.387   1.000 21.397 0 364  SER A C   1 ? 
ATOM   2678 O O   . SER A 1 360 ? 32.675  -36.120 6.158   1.000 21.395 0 364  SER A O   1 ? 
ATOM   2679 C CB  . SER A 1 360 ? 32.134  -33.964 8.564   1.000 26.808 0 364  SER A CB  1 ? 
ATOM   2680 O OG  . SER A 1 360 ? 31.140  -33.139 9.150   1.000 27.819 0 364  SER A OG  1 ? 
ATOM   2681 N N   . PHE A 1 361 ? 33.327  -36.882 8.174   1.000 21.982 0 365  PHE A N   1 ? 
ATOM   2682 C CA  . PHE A 1 361 ? 34.490  -37.564 7.601   1.000 22.150 0 365  PHE A CA  1 ? 
ATOM   2683 C C   . PHE A 1 361 ? 34.072  -38.539 6.512   1.000 21.982 0 365  PHE A C   1 ? 
ATOM   2684 O O   . PHE A 1 361 ? 34.646  -38.550 5.415   1.000 20.031 0 365  PHE A O   1 ? 
ATOM   2685 C CB  . PHE A 1 361 ? 35.286  -38.290 8.684   1.000 18.750 0 365  PHE A CB  1 ? 
ATOM   2686 C CG  . PHE A 1 361 ? 36.513  -38.993 8.158   1.000 18.471 0 365  PHE A CG  1 ? 
ATOM   2687 C CD1 . PHE A 1 361 ? 37.637  -38.263 7.778   1.000 23.337 0 365  PHE A CD1 1 ? 
ATOM   2688 C CD2 . PHE A 1 361 ? 36.542  -40.377 8.039   1.000 16.999 0 365  PHE A CD2 1 ? 
ATOM   2689 C CE1 . PHE A 1 361 ? 38.773  -38.904 7.293   1.000 22.463 0 365  PHE A CE1 1 ? 
ATOM   2690 C CE2 . PHE A 1 361 ? 37.666  -41.028 7.562   1.000 19.376 0 365  PHE A CE2 1 ? 
ATOM   2691 C CZ  . PHE A 1 361 ? 38.794  -40.290 7.183   1.000 21.795 0 365  PHE A CZ  1 ? 
ATOM   2692 N N   . VAL A 1 362 ? 33.063  -39.367 6.788   1.000 20.252 0 366  VAL A N   1 ? 
ATOM   2693 C CA  . VAL A 1 362 ? 32.669  -40.325 5.768   1.000 18.026 0 366  VAL A CA  1 ? 
ATOM   2694 C C   . VAL A 1 362 ? 31.920  -39.639 4.622   1.000 20.223 0 366  VAL A C   1 ? 
ATOM   2695 O O   . VAL A 1 362 ? 32.037  -40.058 3.465   1.000 20.892 0 366  VAL A O   1 ? 
ATOM   2696 C CB  . VAL A 1 362 ? 31.872  -41.473 6.421   1.000 21.816 0 366  VAL A CB  1 ? 
ATOM   2697 C CG1 . VAL A 1 362 ? 30.443  -41.053 6.778   1.000 19.323 0 366  VAL A CG1 1 ? 
ATOM   2698 C CG2 . VAL A 1 362 ? 31.919  -42.678 5.548   1.000 26.995 0 366  VAL A CG2 1 ? 
ATOM   2699 N N   . MET A 1 363 ? 31.185  -38.551 4.894   1.000 18.094 0 367  MET A N   1 ? 
ATOM   2700 C CA  . MET A 1 363 ? 30.550  -37.824 3.796   1.000 19.726 0 367  MET A CA  1 ? 
ATOM   2701 C C   . MET A 1 363 ? 31.583  -37.207 2.861   1.000 20.460 0 367  MET A C   1 ? 
ATOM   2702 O O   . MET A 1 363 ? 31.320  -37.042 1.660   1.000 21.708 0 367  MET A O   1 ? 
ATOM   2703 C CB  . MET A 1 363 ? 29.618  -36.735 4.338   1.000 21.855 0 367  MET A CB  1 ? 
ATOM   2704 C CG  . MET A 1 363 ? 28.396  -37.268 5.085   1.000 21.447 0 367  MET A CG  1 ? 
ATOM   2705 S SD  . MET A 1 363 ? 27.612  -38.688 4.272   1.000 23.811 0 367  MET A SD  1 ? 
ATOM   2706 C CE  . MET A 1 363 ? 27.151  -37.998 2.688   1.000 24.840 0 367  MET A CE  1 ? 
ATOM   2707 N N   . SER A 1 364 ? 32.759  -36.858 3.389   1.000 19.944 0 368  SER A N   1 ? 
ATOM   2708 C CA  . SER A 1 364 ? 33.834  -36.370 2.530   1.000 21.482 0 368  SER A CA  1 ? 
ATOM   2709 C C   . SER A 1 364 ? 34.222  -37.415 1.491   1.000 19.726 0 368  SER A C   1 ? 
ATOM   2710 O O   . SER A 1 364 ? 34.465  -37.084 0.322   1.000 21.532 0 368  SER A O   1 ? 
ATOM   2711 C CB  . SER A 1 364 ? 35.039  -35.985 3.385   1.000 20.805 0 368  SER A CB  1 ? 
ATOM   2712 O OG  . SER A 1 364 ? 36.125  -35.539 2.585   1.000 20.142 0 368  SER A OG  1 ? 
ATOM   2713 N N   . ALA A 1 365 ? 34.281  -38.685 1.894   1.000 21.050 0 369  ALA A N   1 ? 
ATOM   2714 C CA  . ALA A 1 365 ? 34.640  -39.727 0.942   1.000 20.263 0 369  ALA A CA  1 ? 
ATOM   2715 C C   . ALA A 1 365 ? 33.581  -39.838 -0.148  1.000 19.413 0 369  ALA A C   1 ? 
ATOM   2716 O O   . ALA A 1 365 ? 33.900  -39.889 -1.342  1.000 21.142 0 369  ALA A O   1 ? 
ATOM   2717 C CB  . ALA A 1 365 ? 34.827  -41.058 1.669   1.000 20.674 0 369  ALA A CB  1 ? 
ATOM   2718 N N   . SER A 1 366 ? 32.309  -39.837 0.247   1.000 19.429 0 370  SER A N   1 ? 
ATOM   2719 C CA  . SER A 1 366 ? 31.228  -39.887 -0.737  1.000 17.581 0 370  SER A CA  1 ? 
ATOM   2720 C C   . SER A 1 366 ? 31.276  -38.687 -1.664  1.000 22.113 0 370  SER A C   1 ? 
ATOM   2721 O O   . SER A 1 366 ? 31.139  -38.813 -2.886  1.000 20.531 0 370  SER A O   1 ? 
ATOM   2722 C CB  . SER A 1 366 ? 29.876  -39.922 -0.028  1.000 19.489 0 370  SER A CB  1 ? 
ATOM   2723 O OG  . SER A 1 366 ? 29.775  -41.076 0.777   1.000 21.845 0 370  SER A OG  1 ? 
ATOM   2724 N N   . PHE A 1 367 ? 31.433  -37.503 -1.089  1.000 19.260 0 371  PHE A N   1 ? 
ATOM   2725 C CA  . PHE A 1 367 ? 31.302  -36.287 -1.873  1.000 20.558 0 371  PHE A CA  1 ? 
ATOM   2726 C C   . PHE A 1 367 ? 32.544  -36.003 -2.709  1.000 23.021 0 371  PHE A C   1 ? 
ATOM   2727 O O   . PHE A 1 367 ? 32.434  -35.328 -3.741  1.000 21.805 0 371  PHE A O   1 ? 
ATOM   2728 C CB  . PHE A 1 367 ? 30.987  -35.118 -0.942  1.000 18.923 0 371  PHE A CB  1 ? 
ATOM   2729 C CG  . PHE A 1 367 ? 29.598  -35.161 -0.348  1.000 20.739 0 371  PHE A CG  1 ? 
ATOM   2730 C CD1 . PHE A 1 367 ? 28.615  -35.988 -0.874  1.000 22.416 0 371  PHE A CD1 1 ? 
ATOM   2731 C CD2 . PHE A 1 367 ? 29.280  -34.342 0.722   1.000 20.929 0 371  PHE A CD2 1 ? 
ATOM   2732 C CE1 . PHE A 1 367 ? 27.336  -36.002 -0.322  1.000 23.887 0 371  PHE A CE1 1 ? 
ATOM   2733 C CE2 . PHE A 1 367 ? 28.012  -34.345 1.273   1.000 22.732 0 371  PHE A CE2 1 ? 
ATOM   2734 C CZ  . PHE A 1 367 ? 27.037  -35.176 0.747   1.000 23.582 0 371  PHE A CZ  1 ? 
ATOM   2735 N N   . THR A 1 368 ? 33.722  -36.502 -2.297  1.000 20.023 0 372  THR A N   1 ? 
ATOM   2736 C CA  . THR A 1 368 ? 34.884  -36.430 -3.180  1.000 20.829 0 372  THR A CA  1 ? 
ATOM   2737 C C   . THR A 1 368 ? 34.619  -37.216 -4.458  1.000 23.140 0 372  THR A C   1 ? 
ATOM   2738 O O   . THR A 1 368 ? 34.927  -36.745 -5.558  1.000 21.642 0 372  THR A O   1 ? 
ATOM   2739 C CB  . THR A 1 368 ? 36.143  -36.941 -2.465  1.000 21.687 0 372  THR A CB  1 ? 
ATOM   2740 O OG1 . THR A 1 368 ? 36.370  -36.156 -1.284  1.000 22.395 0 372  THR A OG1 1 ? 
ATOM   2741 C CG2 . THR A 1 368 ? 37.382  -36.840 -3.372  1.000 20.202 0 372  THR A CG2 1 ? 
ATOM   2742 N N   . ASN A 1 369 ? 33.992  -38.393 -4.335  1.000 20.895 0 373  ASN A N   1 ? 
ATOM   2743 C CA  . ASN A 1 369 ? 33.574  -39.133 -5.524  1.000 21.992 0 373  ASN A CA  1 ? 
ATOM   2744 C C   . ASN A 1 369 ? 32.598  -38.326 -6.379  1.000 21.195 0 373  ASN A C   1 ? 
ATOM   2745 O O   . ASN A 1 369 ? 32.682  -38.350 -7.610  1.000 22.458 0 373  ASN A O   1 ? 
ATOM   2746 C CB  . ASN A 1 369 ? 32.943  -40.471 -5.119  1.000 19.244 0 373  ASN A CB  1 ? 
ATOM   2747 C CG  . ASN A 1 369 ? 33.988  -41.517 -4.774  1.000 21.245 0 373  ASN A CG  1 ? 
ATOM   2748 O OD1 . ASN A 1 369 ? 34.709  -41.995 -5.653  1.000 24.282 0 373  ASN A OD1 1 ? 
ATOM   2749 N ND2 . ASN A 1 369 ? 34.076  -41.877 -3.501  1.000 20.771 0 373  ASN A ND2 1 ? 
ATOM   2750 N N   . GLN A 1 370 ? 31.656  -37.611 -5.747  1.000 21.303 0 374  GLN A N   1 ? 
ATOM   2751 C CA  . GLN A 1 370 ? 30.707  -36.803 -6.511  1.000 20.500 0 374  GLN A CA  1 ? 
ATOM   2752 C C   . GLN A 1 370 ? 31.426  -35.731 -7.329  1.000 20.484 0 374  GLN A C   1 ? 
ATOM   2753 O O   . GLN A 1 370 ? 31.106  -35.511 -8.506  1.000 23.716 0 374  GLN A O   1 ? 
ATOM   2754 C CB  . GLN A 1 370 ? 29.684  -36.150 -5.575  1.000 22.292 0 374  GLN A CB  1 ? 
ATOM   2755 C CG  . GLN A 1 370 ? 28.477  -37.036 -5.228  1.000 21.689 0 374  GLN A CG  1 ? 
ATOM   2756 C CD  . GLN A 1 370 ? 27.557  -37.296 -6.413  1.000 23.737 0 374  GLN A CD  1 ? 
ATOM   2757 O OE1 . GLN A 1 370 ? 27.736  -36.743 -7.499  1.000 24.590 0 374  GLN A OE1 1 ? 
ATOM   2758 N NE2 . GLN A 1 370 ? 26.552  -38.148 -6.200  1.000 25.808 0 374  GLN A NE2 1 ? 
ATOM   2759 N N   . VAL A 1 371 ? 32.380  -35.030 -6.710  1.000 21.626 0 375  VAL A N   1 ? 
ATOM   2760 C CA  . VAL A 1 371 ? 33.085  -33.970 -7.430  1.000 23.155 0 375  VAL A CA  1 ? 
ATOM   2761 C C   . VAL A 1 371 ? 33.855  -34.555 -8.603  1.000 24.711 0 375  VAL A C   1 ? 
ATOM   2762 O O   . VAL A 1 371 ? 33.836  -34.009 -9.716  1.000 24.537 0 375  VAL A O   1 ? 
ATOM   2763 C CB  . VAL A 1 371 ? 34.015  -33.193 -6.481  1.000 22.390 0 375  VAL A CB  1 ? 
ATOM   2764 C CG1 . VAL A 1 371 ? 34.838  -32.159 -7.277  1.000 22.408 0 375  VAL A CG1 1 ? 
ATOM   2765 C CG2 . VAL A 1 371 ? 33.204  -32.497 -5.408  1.000 24.195 0 375  VAL A CG2 1 ? 
ATOM   2766 N N   . LEU A 1 372 ? 34.549  -35.674 -8.374  1.000 22.390 0 376  LEU A N   1 ? 
ATOM   2767 C CA  . LEU A 1 372 ? 35.293  -36.304 -9.460  1.000 22.674 0 376  LEU A CA  1 ? 
ATOM   2768 C C   . LEU A 1 372 ? 34.360  -36.744 -10.579 1.000 24.666 0 376  LEU A C   1 ? 
ATOM   2769 O O   . LEU A 1 372 ? 34.711  -36.640 -11.760 1.000 23.698 0 376  LEU A O   1 ? 
ATOM   2770 C CB  . LEU A 1 372 ? 36.100  -37.490 -8.934  1.000 20.637 0 376  LEU A CB  1 ? 
ATOM   2771 C CG  . LEU A 1 372 ? 37.218  -37.120 -7.949  1.000 22.753 0 376  LEU A CG  1 ? 
ATOM   2772 C CD1 . LEU A 1 372 ? 37.761  -38.365 -7.270  1.000 25.619 0 376  LEU A CD1 1 ? 
ATOM   2773 C CD2 . LEU A 1 372 ? 38.332  -36.382 -8.677  1.000 22.403 0 376  LEU A CD2 1 ? 
ATOM   2774 N N   . ALA A 1 373 ? 33.161  -37.232 -10.229 1.000 23.161 0 377  ALA A N   1 ? 
ATOM   2775 C CA  . ALA A 1 373 ? 32.211  -37.645 -11.257 1.000 20.850 0 377  ALA A CA  1 ? 
ATOM   2776 C C   . ALA A 1 373 ? 31.722  -36.455 -12.073 1.000 24.258 0 377  ALA A C   1 ? 
ATOM   2777 O O   . ALA A 1 373 ? 31.545  -36.564 -13.294 1.000 25.545 0 377  ALA A O   1 ? 
ATOM   2778 C CB  . ALA A 1 373 ? 31.024  -38.380 -10.624 1.000 21.179 0 377  ALA A CB  1 ? 
ATOM   2779 N N   . GLN A 1 374 ? 31.489  -35.311 -11.421 1.000 22.584 0 378  GLN A N   1 ? 
ATOM   2780 C CA  . GLN A 1 374 ? 31.049  -34.123 -12.152 1.000 23.216 0 378  GLN A CA  1 ? 
ATOM   2781 C C   . GLN A 1 374 ? 32.147  -33.602 -13.074 1.000 24.992 0 378  GLN A C   1 ? 
ATOM   2782 O O   . GLN A 1 374 ? 31.869  -33.187 -14.208 1.000 26.998 0 378  GLN A O   1 ? 
ATOM   2783 C CB  . GLN A 1 374 ? 30.605  -33.041 -11.166 1.000 23.221 0 378  GLN A CB  1 ? 
ATOM   2784 C CG  . GLN A 1 374 ? 29.284  -33.384 -10.460 1.000 23.495 0 378  GLN A CG  1 ? 
ATOM   2785 C CD  . GLN A 1 374 ? 28.108  -33.219 -11.375 1.000 25.027 0 378  GLN A CD  1 ? 
ATOM   2786 O OE1 . GLN A 1 374 ? 28.048  -32.258 -12.143 1.000 25.135 0 378  GLN A OE1 1 ? 
ATOM   2787 N NE2 . GLN A 1 374 ? 27.159  -34.156 -11.315 1.000 26.653 0 378  GLN A NE2 1 ? 
ATOM   2788 N N   . ILE A 1 375 ? 33.400  -33.615 -12.613 1.000 24.950 0 379  ILE A N   1 ? 
ATOM   2789 C CA  . ILE A 1 375 ? 34.501  -33.236 -13.498 1.000 25.450 0 379  ILE A CA  1 ? 
ATOM   2790 C C   . ILE A 1 375 ? 34.546  -34.156 -14.711 1.000 24.771 0 379  ILE A C   1 ? 
ATOM   2791 O O   . ILE A 1 375 ? 34.698  -33.696 -15.851 1.000 27.956 0 379  ILE A O   1 ? 
ATOM   2792 C CB  . ILE A 1 375 ? 35.840  -33.245 -12.738 1.000 25.335 0 379  ILE A CB  1 ? 
ATOM   2793 C CG1 . ILE A 1 375 ? 35.877  -32.126 -11.701 1.000 26.845 0 379  ILE A CG1 1 ? 
ATOM   2794 C CG2 . ILE A 1 375 ? 37.014  -33.093 -13.718 1.000 27.888 0 379  ILE A CG2 1 ? 
ATOM   2795 C CD1 . ILE A 1 375 ? 37.046  -32.224 -10.741 1.000 28.724 0 379  ILE A CD1 1 ? 
ATOM   2796 N N   . GLU A 1 376 ? 34.401  -35.467 -14.489 1.000 24.487 0 380  GLU A N   1 ? 
ATOM   2797 C CA  . GLU A 1 376 ? 34.488  -36.418 -15.593 1.000 26.706 0 380  GLU A CA  1 ? 
ATOM   2798 C C   . GLU A 1 376 ? 33.339  -36.232 -16.580 1.000 28.235 0 380  GLU A C   1 ? 
ATOM   2799 O O   . GLU A 1 376 ? 33.549  -36.275 -17.800 1.000 28.517 0 380  GLU A O   1 ? 
ATOM   2800 C CB  . GLU A 1 376 ? 34.521  -37.852 -15.055 1.000 26.493 0 380  GLU A CB  1 ? 
ATOM   2801 C CG  . GLU A 1 376 ? 34.394  -38.927 -16.132 1.000 31.830 0 380  GLU A CG  1 ? 
ATOM   2802 C CD  . GLU A 1 376 ? 35.628  -39.037 -17.031 1.000 38.857 0 380  GLU A CD  1 ? 
ATOM   2803 O OE1 . GLU A 1 376 ? 35.593  -39.858 -17.977 1.000 35.491 0 380  GLU A OE1 1 ? 
ATOM   2804 O OE2 . GLU A 1 376 ? 36.630  -38.317 -16.793 1.000 35.123 0 380  GLU A OE2 1 ? 
ATOM   2805 N N   . LEU A 1 377 ? 32.119  -36.017 -16.078 1.000 25.937 0 381  LEU A N   1 ? 
ATOM   2806 C CA  . LEU A 1 377 ? 30.995  -35.788 -16.981 1.000 26.466 0 381  LEU A CA  1 ? 
ATOM   2807 C C   . LEU A 1 377 ? 31.139  -34.463 -17.716 1.000 28.814 0 381  LEU A C   1 ? 
ATOM   2808 O O   . LEU A 1 377 ? 30.916  -34.391 -18.929 1.000 29.804 0 381  LEU A O   1 ? 
ATOM   2809 C CB  . LEU A 1 377 ? 29.675  -35.820 -16.213 1.000 23.611 0 381  LEU A CB  1 ? 
ATOM   2810 C CG  . LEU A 1 377 ? 29.207  -37.211 -15.773 1.000 25.108 0 381  LEU A CG  1 ? 
ATOM   2811 C CD1 . LEU A 1 377 ? 27.991  -37.097 -14.859 1.000 26.332 0 381  LEU A CD1 1 ? 
ATOM   2812 C CD2 . LEU A 1 377 ? 28.896  -38.077 -16.998 1.000 27.559 0 381  LEU A CD2 1 ? 
ATOM   2813 N N   . PHE A 1 378 ? 31.510  -33.401 -17.003 1.000 29.264 0 382  PHE A N   1 ? 
ATOM   2814 C CA  . PHE A 1 378 ? 31.613  -32.098 -17.655 1.000 29.119 0 382  PHE A CA  1 ? 
ATOM   2815 C C   . PHE A 1 378 ? 32.648  -32.118 -18.773 1.000 29.075 0 382  PHE A C   1 ? 
ATOM   2816 O O   . PHE A 1 378 ? 32.427  -31.539 -19.844 1.000 31.783 0 382  PHE A O   1 ? 
ATOM   2817 C CB  . PHE A 1 378 ? 31.956  -31.018 -16.627 1.000 28.880 0 382  PHE A CB  1 ? 
ATOM   2818 C CG  . PHE A 1 378 ? 32.018  -29.636 -17.209 1.000 30.156 0 382  PHE A CG  1 ? 
ATOM   2819 C CD1 . PHE A 1 378 ? 30.888  -29.050 -17.765 1.000 28.119 0 382  PHE A CD1 1 ? 
ATOM   2820 C CD2 . PHE A 1 378 ? 33.208  -28.926 -17.215 1.000 31.999 0 382  PHE A CD2 1 ? 
ATOM   2821 C CE1 . PHE A 1 378 ? 30.944  -27.781 -18.320 1.000 32.596 0 382  PHE A CE1 1 ? 
ATOM   2822 C CE2 . PHE A 1 378 ? 33.266  -27.660 -17.766 1.000 35.454 0 382  PHE A CE2 1 ? 
ATOM   2823 C CZ  . PHE A 1 378 ? 32.134  -27.086 -18.313 1.000 34.883 0 382  PHE A CZ  1 ? 
ATOM   2824 N N   . GLN A 1 379 ? 33.774  -32.797 -18.550 1.000 29.980 0 383  GLN A N   1 ? 
ATOM   2825 C CA  . GLN A 1 379 ? 34.854  -32.789 -19.529 1.000 31.980 0 383  GLN A CA  1 ? 
ATOM   2826 C C   . GLN A 1 379 ? 34.658  -33.841 -20.613 1.000 38.028 0 383  GLN A C   1 ? 
ATOM   2827 O O   . GLN A 1 379 ? 34.936  -33.576 -21.789 1.000 38.515 0 383  GLN A O   1 ? 
ATOM   2828 C CB  . GLN A 1 379 ? 36.192  -33.011 -18.830 1.000 31.162 0 383  GLN A CB  1 ? 
ATOM   2829 C CG  . GLN A 1 379 ? 36.620  -31.867 -17.941 1.000 34.130 0 383  GLN A CG  1 ? 
ATOM   2830 C CD  . GLN A 1 379 ? 37.940  -32.140 -17.249 1.000 37.652 0 383  GLN A CD  1 ? 
ATOM   2831 O OE1 . GLN A 1 379 ? 38.434  -33.266 -17.256 1.000 38.055 0 383  GLN A OE1 1 ? 
ATOM   2832 N NE2 . GLN A 1 379 ? 38.516  -31.108 -16.643 1.000 36.104 0 383  GLN A NE2 1 ? 
ATOM   2833 N N   . ASN A 1 380 ? 34.172  -35.033 -20.248 1.000 33.778 0 384  ASN A N   1 ? 
ATOM   2834 C CA  . ASN A 1 380 ? 34.290  -36.191 -21.129 1.000 36.336 0 384  ASN A CA  1 ? 
ATOM   2835 C C   . ASN A 1 380 ? 32.968  -36.894 -21.411 1.000 34.907 0 384  ASN A C   1 ? 
ATOM   2836 O O   . ASN A 1 380 ? 32.986  -38.042 -21.869 1.000 32.517 0 384  ASN A O   1 ? 
ATOM   2837 C CB  . ASN A 1 380 ? 35.287  -37.195 -20.544 1.000 35.275 0 384  ASN A CB  1 ? 
ATOM   2838 C CG  . ASN A 1 380 ? 36.685  -36.632 -20.464 1.000 37.362 0 384  ASN A CG  1 ? 
ATOM   2839 O OD1 . ASN A 1 380 ? 37.169  -36.040 -21.424 1.000 40.434 0 384  ASN A OD1 1 ? 
ATOM   2840 N ND2 . ASN A 1 380 ? 37.339  -36.804 -19.318 1.000 41.450 0 384  ASN A ND2 1 ? 
ATOM   2841 N N   . SER A 1 381 ? 31.824  -36.243 -21.166 1.000 33.272 0 385  SER A N   1 ? 
ATOM   2842 C CA  . SER A 1 381 ? 30.544  -36.920 -21.378 1.000 33.888 0 385  SER A CA  1 ? 
ATOM   2843 C C   . SER A 1 381 ? 30.381  -37.430 -22.805 1.000 36.804 0 385  SER A C   1 ? 
ATOM   2844 O O   . SER A 1 381 ? 29.636  -38.391 -23.023 1.000 35.981 0 385  SER A O   1 ? 
ATOM   2845 C CB  . SER A 1 381 ? 29.374  -35.998 -21.030 1.000 34.609 0 385  SER A CB  1 ? 
ATOM   2846 O OG  . SER A 1 381 ? 29.357  -34.857 -21.863 1.000 38.294 0 385  SER A OG  1 ? 
ATOM   2847 N N   . SER A 1 382 ? 31.072  -36.825 -23.777 1.000 40.694 0 386  SER A N   1 ? 
ATOM   2848 C CA  . SER A 1 382 ? 30.993  -37.302 -25.153 1.000 43.592 0 386  SER A CA  1 ? 
ATOM   2849 C C   . SER A 1 382 ? 31.497  -38.731 -25.300 1.000 41.718 0 386  SER A C   1 ? 
ATOM   2850 O O   . SER A 1 382 ? 31.109  -39.416 -26.251 1.000 44.337 0 386  SER A O   1 ? 
ATOM   2851 C CB  . SER A 1 382 ? 31.793  -36.381 -26.076 1.000 44.161 0 386  SER A CB  1 ? 
ATOM   2852 O OG  . SER A 1 382 ? 33.184  -36.506 -25.833 1.000 45.863 0 386  SER A OG  1 ? 
ATOM   2853 N N   . GLN A 1 383 ? 32.351  -39.193 -24.384 1.000 39.894 0 387  GLN A N   1 ? 
ATOM   2854 C CA  . GLN A 1 383 ? 32.899  -40.542 -24.441 1.000 41.668 0 387  GLN A CA  1 ? 
ATOM   2855 C C   . GLN A 1 383 ? 31.930  -41.598 -23.934 1.000 41.018 0 387  GLN A C   1 ? 
ATOM   2856 O O   . GLN A 1 383 ? 32.245  -42.792 -24.014 1.000 41.529 0 387  GLN A O   1 ? 
ATOM   2857 C CB  . GLN A 1 383 ? 34.191  -40.630 -23.622 1.000 45.737 0 387  GLN A CB  1 ? 
ATOM   2858 C CG  . GLN A 1 383 ? 35.163  -39.488 -23.839 1.000 56.530 0 387  GLN A CG  1 ? 
ATOM   2859 C CD  . GLN A 1 383 ? 35.759  -39.503 -25.223 1.000 67.734 0 387  GLN A CD  1 ? 
ATOM   2860 O OE1 . GLN A 1 383 ? 36.789  -40.135 -25.459 1.000 75.322 0 387  GLN A OE1 1 ? 
ATOM   2861 N NE2 . GLN A 1 383 ? 35.114  -38.808 -26.154 1.000 70.608 0 387  GLN A NE2 1 ? 
ATOM   2862 N N   . TYR A 1 384 ? 30.780  -41.194 -23.408 1.000 35.123 0 388  TYR A N   1 ? 
ATOM   2863 C CA  . TYR A 1 384 ? 29.852  -42.096 -22.746 1.000 32.686 0 388  TYR A CA  1 ? 
ATOM   2864 C C   . TYR A 1 384 ? 28.566  -42.234 -23.547 1.000 33.299 0 388  TYR A C   1 ? 
ATOM   2865 O O   . TYR A 1 384 ? 28.113  -41.291 -24.201 1.000 35.789 0 388  TYR A O   1 ? 
ATOM   2866 C CB  . TYR A 1 384 ? 29.505  -41.586 -21.350 1.000 30.006 0 388  TYR A CB  1 ? 
ATOM   2867 C CG  . TYR A 1 384 ? 30.659  -41.585 -20.376 1.000 33.296 0 388  TYR A CG  1 ? 
ATOM   2868 C CD1 . TYR A 1 384 ? 31.537  -40.512 -20.305 1.000 35.025 0 388  TYR A CD1 1 ? 
ATOM   2869 C CD2 . TYR A 1 384 ? 30.852  -42.651 -19.510 1.000 31.433 0 388  TYR A CD2 1 ? 
ATOM   2870 C CE1 . TYR A 1 384 ? 32.589  -40.512 -19.406 1.000 33.172 0 388  TYR A CE1 1 ? 
ATOM   2871 C CE2 . TYR A 1 384 ? 31.890  -42.658 -18.604 1.000 34.694 0 388  TYR A CE2 1 ? 
ATOM   2872 C CZ  . TYR A 1 384 ? 32.754  -41.589 -18.554 1.000 37.815 0 388  TYR A CZ  1 ? 
ATOM   2873 O OH  . TYR A 1 384 ? 33.791  -41.613 -17.651 1.000 37.878 0 388  TYR A OH  1 ? 
ATOM   2874 N N   . GLN A 1 385 ? 27.969  -43.413 -23.469 1.000 34.559 0 389  GLN A N   1 ? 
ATOM   2875 C CA  . GLN A 1 385 ? 26.637  -43.630 -23.999 1.000 36.296 0 389  GLN A CA  1 ? 
ATOM   2876 C C   . GLN A 1 385 ? 25.616  -43.466 -22.876 1.000 34.033 0 389  GLN A C   1 ? 
ATOM   2877 O O   . GLN A 1 385 ? 25.953  -43.154 -21.730 1.000 31.075 0 389  GLN A O   1 ? 
ATOM   2878 C CB  . GLN A 1 385 ? 26.551  -45.004 -24.661 1.000 40.189 0 389  GLN A CB  1 ? 
ATOM   2879 C CG  . GLN A 1 385 ? 27.629  -45.211 -25.715 1.000 47.214 0 389  GLN A CG  1 ? 
ATOM   2880 C CD  . GLN A 1 385 ? 27.623  -46.609 -26.294 1.000 59.918 0 389  GLN A CD  1 ? 
ATOM   2881 O OE1 . GLN A 1 385 ? 26.902  -46.894 -27.250 1.000 64.450 0 389  GLN A OE1 1 ? 
ATOM   2882 N NE2 . GLN A 1 385 ? 28.431  -47.492 -25.716 1.000 63.323 0 389  GLN A NE2 1 ? 
ATOM   2883 N N   . ASN A 1 386 ? 24.344  -43.672 -23.213 1.000 30.598 0 390  ASN A N   1 ? 
ATOM   2884 C CA  . ASN A 1 386 ? 23.254  -43.522 -22.252 1.000 30.962 0 390  ASN A CA  1 ? 
ATOM   2885 C C   . ASN A 1 386 ? 23.118  -44.814 -21.446 1.000 29.890 0 390  ASN A C   1 ? 
ATOM   2886 O O   . ASN A 1 386 ? 22.155  -45.579 -21.561 1.000 31.962 0 390  ASN A O   1 ? 
ATOM   2887 C CB  . ASN A 1 386 ? 21.963  -43.152 -22.972 1.000 31.388 0 390  ASN A CB  1 ? 
ATOM   2888 C CG  . ASN A 1 386 ? 22.027  -41.778 -23.625 1.000 34.425 0 390  ASN A CG  1 ? 
ATOM   2889 O OD1 . ASN A 1 386 ? 22.819  -40.918 -23.234 1.000 34.454 0 390  ASN A OD1 1 ? 
ATOM   2890 N ND2 . ASN A 1 386 ? 21.185  -41.565 -24.631 1.000 36.697 0 390  ASN A ND2 1 ? 
ATOM   2891 N N   . GLN A 1 387 ? 24.126  -45.038 -20.600 1.000 30.193 0 391  GLN A N   1 ? 
ATOM   2892 C CA  . GLN A 1 387 ? 24.244  -46.222 -19.765 1.000 28.540 0 391  GLN A CA  1 ? 
ATOM   2893 C C   . GLN A 1 387 ? 24.757  -45.792 -18.398 1.000 27.240 0 391  GLN A C   1 ? 
ATOM   2894 O O   . GLN A 1 387 ? 25.124  -44.635 -18.186 1.000 27.748 0 391  GLN A O   1 ? 
ATOM   2895 C CB  . GLN A 1 387 ? 25.209  -47.263 -20.365 1.000 32.088 0 391  GLN A CB  1 ? 
ATOM   2896 C CG  . GLN A 1 387 ? 24.917  -47.680 -21.799 1.000 40.547 0 391  GLN A CG  1 ? 
ATOM   2897 C CD  . GLN A 1 387 ? 26.090  -48.409 -22.442 1.000 44.645 0 391  GLN A CD  1 ? 
ATOM   2898 O OE1 . GLN A 1 387 ? 26.979  -48.910 -21.753 1.000 48.406 0 391  GLN A OE1 1 ? 
ATOM   2899 N NE2 . GLN A 1 387 ? 26.098  -48.464 -23.767 1.000 49.132 0 391  GLN A NE2 1 ? 
ATOM   2900 N N   . VAL A 1 388 ? 24.807  -46.745 -17.472 1.000 26.061 0 392  VAL A N   1 ? 
ATOM   2901 C CA  . VAL A 1 388 ? 25.331  -46.510 -16.129 1.000 23.974 0 392  VAL A CA  1 ? 
ATOM   2902 C C   . VAL A 1 388 ? 26.794  -46.930 -16.089 1.000 26.474 0 392  VAL A C   1 ? 
ATOM   2903 O O   . VAL A 1 388 ? 27.137  -48.047 -16.496 1.000 28.224 0 392  VAL A O   1 ? 
ATOM   2904 C CB  . VAL A 1 388 ? 24.521  -47.276 -15.072 1.000 25.906 0 392  VAL A CB  1 ? 
ATOM   2905 C CG1 . VAL A 1 388 ? 25.073  -46.978 -13.686 1.000 26.545 0 392  VAL A CG1 1 ? 
ATOM   2906 C CG2 . VAL A 1 388 ? 23.023  -46.915 -15.166 1.000 27.756 0 392  VAL A CG2 1 ? 
ATOM   2907 N N   . TYR A 1 389 ? 27.651  -46.049 -15.571 1.000 22.732 0 393  TYR A N   1 ? 
ATOM   2908 C CA  . TYR A 1 389 ? 29.091  -46.277 -15.483 1.000 22.416 0 393  TYR A CA  1 ? 
ATOM   2909 C C   . TYR A 1 389 ? 29.565  -46.051 -14.052 1.000 23.577 0 393  TYR A C   1 ? 
ATOM   2910 O O   . TYR A 1 389 ? 28.900  -45.378 -13.263 1.000 25.337 0 393  TYR A O   1 ? 
ATOM   2911 C CB  . TYR A 1 389 ? 29.859  -45.335 -16.411 1.000 22.837 0 393  TYR A CB  1 ? 
ATOM   2912 C CG  . TYR A 1 389 ? 29.513  -45.462 -17.881 1.000 26.685 0 393  TYR A CG  1 ? 
ATOM   2913 C CD1 . TYR A 1 389 ? 28.401  -44.816 -18.415 1.000 26.251 0 393  TYR A CD1 1 ? 
ATOM   2914 C CD2 . TYR A 1 389 ? 30.309  -46.210 -18.732 1.000 31.491 0 393  TYR A CD2 1 ? 
ATOM   2915 C CE1 . TYR A 1 389 ? 28.089  -44.925 -19.761 1.000 30.483 0 393  TYR A CE1 1 ? 
ATOM   2916 C CE2 . TYR A 1 389 ? 30.009  -46.323 -20.075 1.000 32.743 0 393  TYR A CE2 1 ? 
ATOM   2917 C CZ  . TYR A 1 389 ? 28.898  -45.678 -20.585 1.000 34.215 0 393  TYR A CZ  1 ? 
ATOM   2918 O OH  . TYR A 1 389 ? 28.597  -45.787 -21.925 1.000 34.849 0 393  TYR A OH  1 ? 
ATOM   2919 N N   . VAL A 1 390 ? 30.736  -46.605 -13.721 1.000 23.882 0 394  VAL A N   1 ? 
ATOM   2920 C CA  . VAL A 1 390 ? 31.417  -46.269 -12.474 1.000 23.061 0 394  VAL A CA  1 ? 
ATOM   2921 C C   . VAL A 1 390 ? 32.763  -45.634 -12.806 1.000 23.342 0 394  VAL A C   1 ? 
ATOM   2922 O O   . VAL A 1 390 ? 33.341  -45.862 -13.871 1.000 25.566 0 394  VAL A O   1 ? 
ATOM   2923 C CB  . VAL A 1 390 ? 31.622  -47.487 -11.545 1.000 23.932 0 394  VAL A CB  1 ? 
ATOM   2924 C CG1 . VAL A 1 390 ? 30.283  -47.988 -11.000 1.000 24.824 0 394  VAL A CG1 1 ? 
ATOM   2925 C CG2 . VAL A 1 390 ? 32.381  -48.611 -12.263 1.000 25.937 0 394  VAL A CG2 1 ? 
ATOM   2926 N N   . LEU A 1 391 ? 33.266  -44.838 -11.861 1.000 22.016 0 395  LEU A N   1 ? 
ATOM   2927 C CA  . LEU A 1 391 ? 34.594  -44.253 -11.993 1.000 23.758 0 395  LEU A CA  1 ? 
ATOM   2928 C C   . LEU A 1 391 ? 35.665  -45.337 -11.886 1.000 23.295 0 395  LEU A C   1 ? 
ATOM   2929 O O   . LEU A 1 391 ? 35.471  -46.345 -11.204 1.000 23.274 0 395  LEU A O   1 ? 
ATOM   2930 C CB  . LEU A 1 391 ? 34.834  -43.209 -10.903 1.000 28.464 0 395  LEU A CB  1 ? 
ATOM   2931 C CG  . LEU A 1 391 ? 33.908  -41.992 -10.893 1.000 31.133 0 395  LEU A CG  1 ? 
ATOM   2932 C CD1 . LEU A 1 391 ? 34.222  -41.101 -9.696  1.000 35.094 0 395  LEU A CD1 1 ? 
ATOM   2933 C CD2 . LEU A 1 391 ? 34.050  -41.232 -12.188 1.000 29.430 0 395  LEU A CD2 1 ? 
ATOM   2934 N N   . PRO A 1 392 ? 36.816  -45.130 -12.521 1.000 23.608 0 396  PRO A N   1 ? 
ATOM   2935 C CA  . PRO A 1 392 ? 37.888  -46.132 -12.470 1.000 21.463 0 396  PRO A CA  1 ? 
ATOM   2936 C C   . PRO A 1 392 ? 38.478  -46.298 -11.077 1.000 22.974 0 396  PRO A C   1 ? 
ATOM   2937 O O   . PRO A 1 392 ? 38.427  -45.408 -10.222 1.000 21.761 0 396  PRO A O   1 ? 
ATOM   2938 C CB  . PRO A 1 392 ? 38.950  -45.582 -13.432 1.000 24.532 0 396  PRO A CB  1 ? 
ATOM   2939 C CG  . PRO A 1 392 ? 38.271  -44.516 -14.219 1.000 32.772 0 396  PRO A CG  1 ? 
ATOM   2940 C CD  . PRO A 1 392 ? 37.139  -43.995 -13.402 1.000 25.174 0 396  PRO A CD  1 ? 
ATOM   2941 N N   . LYS A 1 393 ? 39.094  -47.466 -10.883 1.000 21.534 0 397  LYS A N   1 ? 
ATOM   2942 C CA  . LYS A 1 393 ? 39.659  -47.809 -9.581  1.000 21.718 0 397  LYS A CA  1 ? 
ATOM   2943 C C   . LYS A 1 393 ? 40.753  -46.837 -9.133  1.000 21.689 0 397  LYS A C   1 ? 
ATOM   2944 O O   . LYS A 1 393 ? 40.893  -46.591 -7.931  1.000 22.189 0 397  LYS A O   1 ? 
ATOM   2945 C CB  . LYS A 1 393 ? 40.210  -49.239 -9.611  1.000 22.468 0 397  LYS A CB  1 ? 
ATOM   2946 C CG  . LYS A 1 393 ? 40.618  -49.768 -8.231  1.000 20.760 0 397  LYS A CG  1 ? 
ATOM   2947 C CD  . LYS A 1 393 ? 40.889  -51.268 -8.234  1.000 22.129 0 397  LYS A CD  1 ? 
ATOM   2948 C CE  . LYS A 1 393 ? 39.596  -52.078 -8.373  1.000 22.184 0 397  LYS A CE  1 ? 
ATOM   2949 N NZ  . LYS A 1 393 ? 38.542  -51.661 -7.389  1.000 19.813 0 397  LYS A NZ  1 ? 
ATOM   2950 N N   . VAL A 1 394 ? 41.550  -46.284 -10.058 1.000 22.071 0 398  VAL A N   1 ? 
ATOM   2951 C CA  . VAL A 1 394 ? 42.610  -45.381 -9.610  1.000 23.882 0 398  VAL A CA  1 ? 
ATOM   2952 C C   . VAL A 1 394 ? 42.027  -44.152 -8.926  1.000 21.650 0 398  VAL A C   1 ? 
ATOM   2953 O O   . VAL A 1 394 ? 42.656  -43.584 -8.019  1.000 24.642 0 398  VAL A O   1 ? 
ATOM   2954 C CB  . VAL A 1 394 ? 43.539  -44.986 -10.775 1.000 29.554 0 398  VAL A CB  1 ? 
ATOM   2955 C CG1 . VAL A 1 394 ? 44.353  -46.177 -11.213 1.000 34.649 0 398  VAL A CG1 1 ? 
ATOM   2956 C CG2 . VAL A 1 394 ? 42.742  -44.401 -11.934 1.000 29.243 0 398  VAL A CG2 1 ? 
ATOM   2957 N N   . LEU A 1 395 ? 40.827  -43.719 -9.338  1.000 22.005 0 399  LEU A N   1 ? 
ATOM   2958 C CA  . LEU A 1 395 ? 40.199  -42.584 -8.664  1.000 23.084 0 399  LEU A CA  1 ? 
ATOM   2959 C C   . LEU A 1 395 ? 39.609  -43.004 -7.322  1.000 21.821 0 399  LEU A C   1 ? 
ATOM   2960 O O   . LEU A 1 395 ? 39.639  -42.233 -6.358  1.000 22.908 0 399  LEU A O   1 ? 
ATOM   2961 C CB  . LEU A 1 395 ? 39.108  -41.973 -9.546  1.000 25.029 0 399  LEU A CB  1 ? 
ATOM   2962 C CG  . LEU A 1 395 ? 39.551  -41.182 -10.777 1.000 29.856 0 399  LEU A CG  1 ? 
ATOM   2963 C CD1 . LEU A 1 395 ? 38.340  -40.550 -11.441 1.000 31.801 0 399  LEU A CD1 1 ? 
ATOM   2964 C CD2 . LEU A 1 395 ? 40.567  -40.120 -10.387 1.000 32.578 0 399  LEU A CD2 1 ? 
ATOM   2965 N N   . ASP A 1 396 ? 39.043  -44.210 -7.261  1.000 21.392 0 400  ASP A N   1 ? 
ATOM   2966 C CA  . ASP A 1 396 ? 38.591  -44.777 -5.992  1.000 21.476 0 400  ASP A CA  1 ? 
ATOM   2967 C C   . ASP A 1 396 ? 39.744  -44.810 -4.992  1.000 22.663 0 400  ASP A C   1 ? 
ATOM   2968 O O   . ASP A 1 396 ? 39.608  -44.384 -3.834  1.000 20.974 0 400  ASP A O   1 ? 
ATOM   2969 C CB  . ASP A 1 396 ? 38.050  -46.194 -6.263  1.000 20.460 0 400  ASP A CB  1 ? 
ATOM   2970 C CG  . ASP A 1 396 ? 36.818  -46.559 -5.446  1.000 25.500 0 400  ASP A CG  1 ? 
ATOM   2971 O OD1 . ASP A 1 396 ? 36.489  -45.882 -4.448  1.000 22.397 0 400  ASP A OD1 1 ? 
ATOM   2972 O OD2 . ASP A 1 396 ? 36.178  -47.571 -5.818  1.000 23.803 0 400  ASP A OD2 1 ? 
ATOM   2973 N N   . GLU A 1 397 ? 40.904  -45.301 -5.436  1.000 19.452 0 401  GLU A N   1 ? 
ATOM   2974 C CA  . GLU A 1 397 ? 42.070  -45.350 -4.557  1.000 19.023 0 401  GLU A CA  1 ? 
ATOM   2975 C C   . GLU A 1 397 ? 42.525  -43.951 -4.168  1.000 21.484 0 401  GLU A C   1 ? 
ATOM   2976 O O   . GLU A 1 397 ? 42.937  -43.721 -3.023  1.000 20.676 0 401  GLU A O   1 ? 
ATOM   2977 C CB  . GLU A 1 397 ? 43.210  -46.117 -5.234  1.000 21.200 0 401  GLU A CB  1 ? 
ATOM   2978 C CG  . GLU A 1 397 ? 42.894  -47.597 -5.346  1.000 20.310 0 401  GLU A CG  1 ? 
ATOM   2979 C CD  . GLU A 1 397 ? 43.954  -48.397 -6.075  1.000 21.818 0 401  GLU A CD  1 ? 
ATOM   2980 O OE1 . GLU A 1 397 ? 43.816  -49.643 -6.108  1.000 21.753 0 401  GLU A OE1 1 ? 
ATOM   2981 O OE2 . GLU A 1 397 ? 44.922  -47.795 -6.600  1.000 23.137 0 401  GLU A OE2 1 ? 
ATOM   2982 N N   . LYS A 1 398 ? 42.467  -43.002 -5.112  1.000 20.066 0 402  LYS A N   1 ? 
ATOM   2983 C CA  . LYS A 1 398 ? 42.802  -41.618 -4.794  1.000 22.479 0 402  LYS A CA  1 ? 
ATOM   2984 C C   . LYS A 1 398 ? 41.912  -41.076 -3.682  1.000 21.976 0 402  LYS A C   1 ? 
ATOM   2985 O O   . LYS A 1 398 ? 42.407  -40.433 -2.744  1.000 22.150 0 402  LYS A O   1 ? 
ATOM   2986 C CB  . LYS A 1 398 ? 42.685  -40.740 -6.043  1.000 22.355 0 402  LYS A CB  1 ? 
ATOM   2987 C CG  . LYS A 1 398 ? 42.861  -39.249 -5.737  1.000 26.016 0 402  LYS A CG  1 ? 
ATOM   2988 C CD  . LYS A 1 398 ? 42.900  -38.406 -7.006  1.000 27.761 0 402  LYS A CD  1 ? 
ATOM   2989 C CE  . LYS A 1 398 ? 43.167  -36.941 -6.665  1.000 30.377 0 402  LYS A CE  1 ? 
ATOM   2990 N NZ  . LYS A 1 398 ? 43.588  -36.190 -7.872  1.000 28.719 0 402  LYS A NZ  1 ? 
ATOM   2991 N N   . VAL A 1 399 ? 40.600  -41.330 -3.757  1.000 20.350 0 403  VAL A N   1 ? 
ATOM   2992 C CA  . VAL A 1 399 ? 39.709  -40.865 -2.693  1.000 19.084 0 403  VAL A CA  1 ? 
ATOM   2993 C C   . VAL A 1 399 ? 40.178  -41.408 -1.346  1.000 19.726 0 403  VAL A C   1 ? 
ATOM   2994 O O   . VAL A 1 399 ? 40.293  -40.663 -0.365  1.000 20.889 0 403  VAL A O   1 ? 
ATOM   2995 C CB  . VAL A 1 399 ? 38.247  -41.258 -2.982  1.000 19.860 0 403  VAL A CB  1 ? 
ATOM   2996 C CG1 . VAL A 1 399 ? 37.362  -40.923 -1.781  1.000 21.124 0 403  VAL A CG1 1 ? 
ATOM   2997 C CG2 . VAL A 1 399 ? 37.733  -40.547 -4.232  1.000 23.529 0 403  VAL A CG2 1 ? 
ATOM   2998 N N   . ALA A 1 400 ? 40.486  -42.709 -1.280  1.000 19.958 0 404  ALA A N   1 ? 
ATOM   2999 C CA  . ALA A 1 400 ? 40.942  -43.279 -0.012  1.000 19.968 0 404  ALA A CA  1 ? 
ATOM   3000 C C   . ALA A 1 400 ? 42.231  -42.612 0.452   1.000 19.276 0 404  ALA A C   1 ? 
ATOM   3001 O O   . ALA A 1 400 ? 42.364  -42.239 1.623   1.000 20.747 0 404  ALA A O   1 ? 
ATOM   3002 C CB  . ALA A 1 400 ? 41.156  -44.790 -0.137  1.000 18.086 0 404  ALA A CB  1 ? 
ATOM   3003 N N   . ARG A 1 401 ? 43.190  -42.446 -0.464  1.000 19.552 0 405  ARG A N   1 ? 
ATOM   3004 C CA  . ARG A 1 401 ? 44.467  -41.833 -0.114  1.000 19.265 0 405  ARG A CA  1 ? 
ATOM   3005 C C   . ARG A 1 401 ? 44.274  -40.475 0.543   1.000 21.482 0 405  ARG A C   1 ? 
ATOM   3006 O O   . ARG A 1 401 ? 44.987  -40.117 1.493   1.000 23.321 0 405  ARG A O   1 ? 
ATOM   3007 C CB  . ARG A 1 401 ? 45.314  -41.656 -1.378  1.000 23.637 0 405  ARG A CB  1 ? 
ATOM   3008 C CG  . ARG A 1 401 ? 45.987  -42.887 -1.897  1.000 31.146 0 405  ARG A CG  1 ? 
ATOM   3009 C CD  . ARG A 1 401 ? 46.845  -42.518 -3.131  1.000 32.178 0 405  ARG A CD  1 ? 
ATOM   3010 N NE  . ARG A 1 401 ? 47.247  -43.708 -3.866  1.000 31.720 0 405  ARG A NE  1 ? 
ATOM   3011 C CZ  . ARG A 1 401 ? 48.301  -44.446 -3.527  1.000 35.181 0 405  ARG A CZ  1 ? 
ATOM   3012 N NH1 . ARG A 1 401 ? 49.039  -44.099 -2.477  1.000 34.059 0 405  ARG A NH1 1 ? 
ATOM   3013 N NH2 . ARG A 1 401 ? 48.623  -45.516 -4.238  1.000 36.533 0 405  ARG A NH2 1 ? 
ATOM   3014 N N   . LEU A 1 402 ? 43.334  -39.686 0.022   1.000 20.192 0 406  LEU A N   1 ? 
ATOM   3015 C CA  . LEU A 1 402 ? 43.137  -38.327 0.512   1.000 22.163 0 406  LEU A CA  1 ? 
ATOM   3016 C C   . LEU A 1 402 ? 42.588  -38.289 1.930   1.000 23.048 0 406  LEU A C   1 ? 
ATOM   3017 O O   . LEU A 1 402 ? 42.635  -37.231 2.571   1.000 24.087 0 406  LEU A O   1 ? 
ATOM   3018 C CB  . LEU A 1 402 ? 42.200  -37.573 -0.425  1.000 22.919 0 406  LEU A CB  1 ? 
ATOM   3019 C CG  . LEU A 1 402 ? 42.754  -37.289 -1.824  1.000 22.103 0 406  LEU A CG  1 ? 
ATOM   3020 C CD1 . LEU A 1 402 ? 41.684  -36.603 -2.668  1.000 23.287 0 406  LEU A CD1 1 ? 
ATOM   3021 C CD2 . LEU A 1 402 ? 43.988  -36.432 -1.726  1.000 25.908 0 406  LEU A CD2 1 ? 
ATOM   3022 N N   . HIS A 1 403 ? 42.063  -39.407 2.431   1.000 20.213 0 407  HIS A N   1 ? 
ATOM   3023 C CA  . HIS A 1 403 ? 41.466  -39.450 3.757   1.000 18.629 0 407  HIS A CA  1 ? 
ATOM   3024 C C   . HIS A 1 403 ? 42.349  -40.139 4.791   1.000 20.981 0 407  HIS A C   1 ? 
ATOM   3025 O O   . HIS A 1 403 ? 41.999  -40.140 5.973   1.000 22.682 0 407  HIS A O   1 ? 
ATOM   3026 C CB  . HIS A 1 403 ? 40.073  -40.125 3.680   1.000 16.644 0 407  HIS A CB  1 ? 
ATOM   3027 C CG  . HIS A 1 403 ? 39.071  -39.296 2.943   1.000 19.100 0 407  HIS A CG  1 ? 
ATOM   3028 N ND1 . HIS A 1 403 ? 38.989  -39.276 1.566   1.000 20.142 0 407  HIS A ND1 1 ? 
ATOM   3029 C CD2 . HIS A 1 403 ? 38.171  -38.385 3.388   1.000 20.192 0 407  HIS A CD2 1 ? 
ATOM   3030 C CE1 . HIS A 1 403 ? 38.056  -38.415 1.197   1.000 20.355 0 407  HIS A CE1 1 ? 
ATOM   3031 N NE2 . HIS A 1 403 ? 37.559  -37.847 2.283   1.000 20.231 0 407  HIS A NE2 1 ? 
ATOM   3032 N N   . LEU A 1 404 ? 43.506  -40.678 4.389   1.000 19.942 0 408  LEU A N   1 ? 
ATOM   3033 C CA  . LEU A 1 404 ? 44.322  -41.437 5.328   1.000 19.971 0 408  LEU A CA  1 ? 
ATOM   3034 C C   . LEU A 1 404 ? 45.025  -40.527 6.326   1.000 20.779 0 408  LEU A C   1 ? 
ATOM   3035 O O   . LEU A 1 404 ? 45.201  -40.902 7.493   1.000 25.311 0 408  LEU A O   1 ? 
ATOM   3036 C CB  . LEU A 1 404 ? 45.356  -42.272 4.581   1.000 20.337 0 408  LEU A CB  1 ? 
ATOM   3037 C CG  . LEU A 1 404 ? 44.871  -43.436 3.713   1.000 23.413 0 408  LEU A CG  1 ? 
ATOM   3038 C CD1 . LEU A 1 404 ? 46.061  -44.043 2.958   1.000 24.063 0 408  LEU A CD1 1 ? 
ATOM   3039 C CD2 . LEU A 1 404 ? 44.178  -44.485 4.541   1.000 23.153 0 408  LEU A CD2 1 ? 
ATOM   3040 N N   . GLY A 1 405 ? 45.445  -39.338 5.882   1.000 21.750 0 409  GLY A N   1 ? 
ATOM   3041 C CA  . GLY A 1 405 ? 46.213  -38.468 6.760   1.000 22.316 0 409  GLY A CA  1 ? 
ATOM   3042 C C   . GLY A 1 405 ? 45.433  -38.027 7.984   1.000 23.987 0 409  GLY A C   1 ? 
ATOM   3043 O O   . GLY A 1 405 ? 45.972  -37.992 9.095   1.000 26.248 0 409  GLY A O   1 ? 
ATOM   3044 N N   . ARG A 1 406 ? 44.151  -37.691 7.800   1.000 21.913 0 410  ARG A N   1 ? 
ATOM   3045 C CA  . ARG A 1 406 ? 43.343  -37.193 8.913   1.000 22.750 0 410  ARG A CA  1 ? 
ATOM   3046 C C   . ARG A 1 406 ? 43.288  -38.199 10.052  1.000 24.532 0 410  ARG A C   1 ? 
ATOM   3047 O O   . ARG A 1 406 ? 43.356  -37.820 11.227  1.000 29.390 0 410  ARG A O   1 ? 
ATOM   3048 C CB  . ARG A 1 406 ? 41.925  -36.856 8.442   1.000 23.448 0 410  ARG A CB  1 ? 
ATOM   3049 C CG  . ARG A 1 406 ? 40.914  -36.561 9.583   1.000 28.240 0 410  ARG A CG  1 ? 
ATOM   3050 C CD  . ARG A 1 406 ? 41.340  -35.329 10.384  1.000 31.241 0 410  ARG A CD  1 ? 
ATOM   3051 N NE  . ARG A 1 406 ? 40.503  -35.058 11.564  1.000 32.820 0 410  ARG A NE  1 ? 
ATOM   3052 C CZ  . ARG A 1 406 ? 40.790  -35.461 12.803  1.000 27.943 0 410  ARG A CZ  1 ? 
ATOM   3053 N NH1 . ARG A 1 406 ? 41.878  -36.191 13.037  1.000 26.698 0 410  ARG A NH1 1 ? 
ATOM   3054 N NH2 . ARG A 1 406 ? 39.995  -35.134 13.821  1.000 27.451 0 410  ARG A NH2 1 ? 
ATOM   3055 N N   . ILE A 1 407 ? 43.176  -39.489 9.732   1.000 23.887 0 411  ILE A N   1 ? 
ATOM   3056 C CA  . ILE A 1 407 ? 43.036  -40.495 10.777  1.000 24.413 0 411  ILE A CA  1 ? 
ATOM   3057 C C   . ILE A 1 407 ? 44.348  -41.220 11.050  1.000 28.093 0 411  ILE A C   1 ? 
ATOM   3058 O O   . ILE A 1 407 ? 44.347  -42.259 11.717  1.000 27.903 0 411  ILE A O   1 ? 
ATOM   3059 C CB  . ILE A 1 407 ? 41.892  -41.479 10.471  1.000 26.806 0 411  ILE A CB  1 ? 
ATOM   3060 C CG1 . ILE A 1 407 ? 42.009  -42.072 9.071   1.000 29.875 0 411  ILE A CG1 1 ? 
ATOM   3061 C CG2 . ILE A 1 407 ? 40.538  -40.777 10.614  1.000 28.082 0 411  ILE A CG2 1 ? 
ATOM   3062 C CD1 . ILE A 1 407 ? 40.834  -42.938 8.741   1.000 36.173 0 411  ILE A CD1 1 ? 
ATOM   3063 N N   . GLY A 1 408 ? 45.470  -40.684 10.559  1.000 24.874 0 412  GLY A N   1 ? 
ATOM   3064 C CA  . GLY A 1 408 ? 46.790  -41.117 10.980  1.000 30.017 0 412  GLY A CA  1 ? 
ATOM   3065 C C   . GLY A 1 408 ? 47.231  -42.469 10.470  1.000 28.643 0 412  GLY A C   1 ? 
ATOM   3066 O O   . GLY A 1 408 ? 48.049  -43.129 11.118  1.000 32.372 0 412  GLY A O   1 ? 
ATOM   3067 N N   . ALA A 1 409 ? 46.723  -42.901 9.320   1.000 23.350 0 413  ALA A N   1 ? 
ATOM   3068 C CA  . ALA A 1 409 ? 47.091  -44.197 8.763   1.000 20.866 0 413  ALA A CA  1 ? 
ATOM   3069 C C   . ALA A 1 409 ? 48.304  -44.037 7.860   1.000 26.951 0 413  ALA A C   1 ? 
ATOM   3070 O O   . ALA A 1 409 ? 48.330  -43.141 7.011   1.000 29.375 0 413  ALA A O   1 ? 
ATOM   3071 C CB  . ALA A 1 409 ? 45.924  -44.791 7.979   1.000 21.313 0 413  ALA A CB  1 ? 
ATOM   3072 N N   . LYS A 1 410 ? 49.304  -44.899 8.045   1.000 20.760 0 414  LYS A N   1 ? 
ATOM   3073 C CA  . LYS A 1 410 ? 50.551  -44.832 7.292   1.000 21.234 0 414  LYS A CA  1 ? 
ATOM   3074 C C   . LYS A 1 410 ? 50.615  -46.014 6.339   1.000 24.590 0 414  LYS A C   1 ? 
ATOM   3075 O O   . LYS A 1 410 ? 50.617  -47.170 6.779   1.000 23.250 0 414  LYS A O   1 ? 
ATOM   3076 C CB  . LYS A 1 410 ? 51.775  -44.835 8.209   1.000 21.345 0 414  LYS A CB  1 ? 
ATOM   3077 C CG  . LYS A 1 410 ? 53.094  -44.688 7.448   1.000 24.329 0 414  LYS A CG  1 ? 
ATOM   3078 C CD  . LYS A 1 410 ? 54.281  -44.489 8.372   1.000 25.006 0 414  LYS A CD  1 ? 
ATOM   3079 C CE  . LYS A 1 410 ? 55.552  -44.253 7.563   1.000 31.270 0 414  LYS A CE  1 ? 
ATOM   3080 N NZ  . LYS A 1 410 ? 56.738  -44.070 8.445   1.000 31.314 0 414  LYS A NZ  1 ? 
ATOM   3081 N N   . LEU A 1 411 ? 50.695  -45.718 5.046   1.000 21.703 0 415  LEU A N   1 ? 
ATOM   3082 C CA  . LEU A 1 411 ? 50.723  -46.750 4.019   1.000 20.913 0 415  LEU A CA  1 ? 
ATOM   3083 C C   . LEU A 1 411 ? 52.125  -47.322 3.858   1.000 21.095 0 415  LEU A C   1 ? 
ATOM   3084 O O   . LEU A 1 411 ? 53.121  -46.589 3.901   1.000 24.090 0 415  LEU A O   1 ? 
ATOM   3085 C CB  . LEU A 1 411 ? 50.259  -46.159 2.692   1.000 25.519 0 415  LEU A CB  1 ? 
ATOM   3086 C CG  . LEU A 1 411 ? 49.333  -46.876 1.726   1.000 32.362 0 415  LEU A CG  1 ? 
ATOM   3087 C CD1 . LEU A 1 411 ? 48.151  -47.526 2.438   1.000 24.642 0 415  LEU A CD1 1 ? 
ATOM   3088 C CD2 . LEU A 1 411 ? 48.868  -45.872 0.680   1.000 26.680 0 415  LEU A CD2 1 ? 
ATOM   3089 N N   . THR A 1 412 ? 52.194  -48.634 3.653   1.000 19.573 0 416  THR A N   1 ? 
ATOM   3090 C CA  . THR A 1 412 ? 53.422  -49.302 3.239   1.000 20.213 0 416  THR A CA  1 ? 
ATOM   3091 C C   . THR A 1 412 ? 53.590  -49.145 1.731   1.000 19.329 0 416  THR A C   1 ? 
ATOM   3092 O O   . THR A 1 412 ? 52.602  -49.143 0.989   1.000 20.531 0 416  THR A O   1 ? 
ATOM   3093 C CB  . THR A 1 412 ? 53.340  -50.785 3.626   1.000 23.577 0 416  THR A CB  1 ? 
ATOM   3094 O OG1 . THR A 1 412 ? 53.251  -50.895 5.050   1.000 23.158 0 416  THR A OG1 1 ? 
ATOM   3095 C CG2 . THR A 1 412 ? 54.561  -51.577 3.143   1.000 21.882 0 416  THR A CG2 1 ? 
ATOM   3096 N N   . GLN A 1 413 ? 54.838  -48.981 1.282   1.000 22.674 0 417  GLN A N   1 ? 
ATOM   3097 C CA  . GLN A 1 413 ? 55.142  -48.868 -0.141  1.000 21.658 0 417  GLN A CA  1 ? 
ATOM   3098 C C   . GLN A 1 413 ? 55.694  -50.193 -0.656  1.000 20.774 0 417  GLN A C   1 ? 
ATOM   3099 O O   . GLN A 1 413 ? 56.621  -50.758 -0.065  1.000 24.337 0 417  GLN A O   1 ? 
ATOM   3100 C CB  . GLN A 1 413 ? 56.152  -47.740 -0.389  1.000 25.840 0 417  GLN A CB  1 ? 
ATOM   3101 C CG  . GLN A 1 413 ? 55.748  -46.394 0.215   1.000 34.657 0 417  GLN A CG  1 ? 
ATOM   3102 C CD  . GLN A 1 413 ? 54.491  -45.809 -0.407  1.000 47.419 0 417  GLN A CD  1 ? 
ATOM   3103 O OE1 . GLN A 1 413 ? 54.268  -45.932 -1.611  1.000 53.559 0 417  GLN A OE1 1 ? 
ATOM   3104 N NE2 . GLN A 1 413 ? 53.660  -45.169 0.416   1.000 48.685 0 417  GLN A NE2 1 ? 
ATOM   3105 N N   . LEU A 1 414 ? 55.114  -50.692 -1.748  1.000 19.313 0 418  LEU A N   1 ? 
ATOM   3106 C CA  . LEU A 1 414 ? 55.669  -51.870 -2.407  1.000 20.995 0 418  LEU A CA  1 ? 
ATOM   3107 C C   . LEU A 1 414 ? 57.070  -51.606 -2.940  1.000 22.511 0 418  LEU A C   1 ? 
ATOM   3108 O O   . LEU A 1 414 ? 57.349  -50.548 -3.510  1.000 25.619 0 418  LEU A O   1 ? 
ATOM   3109 C CB  . LEU A 1 414 ? 54.788  -52.283 -3.579  1.000 20.521 0 418  LEU A CB  1 ? 
ATOM   3110 C CG  . LEU A 1 414 ? 53.385  -52.783 -3.259  1.000 19.710 0 418  LEU A CG  1 ? 
ATOM   3111 C CD1 . LEU A 1 414 ? 52.549  -52.712 -4.532  1.000 21.595 0 418  LEU A CD1 1 ? 
ATOM   3112 C CD2 . LEU A 1 414 ? 53.484  -54.212 -2.703  1.000 23.042 0 418  LEU A CD2 1 ? 
ATOM   3113 N N   . SER A 1 415 ? 57.944  -52.601 -2.791  1.000 21.095 0 419  SER A N   1 ? 
ATOM   3114 C CA  . SER A 1 415 ? 59.173  -52.647 -3.567  1.000 22.324 0 419  SER A CA  1 ? 
ATOM   3115 C C   . SER A 1 415 ? 58.861  -53.068 -5.005  1.000 21.874 0 419  SER A C   1 ? 
ATOM   3116 O O   . SER A 1 415 ? 57.763  -53.548 -5.311  1.000 23.066 0 419  SER A O   1 ? 
ATOM   3117 C CB  . SER A 1 415 ? 60.156  -53.629 -2.937  1.000 22.337 0 419  SER A CB  1 ? 
ATOM   3118 O OG  . SER A 1 415 ? 59.642  -54.945 -3.067  1.000 23.192 0 419  SER A OG  1 ? 
ATOM   3119 N N   . ASN A 1 416 ? 59.854  -52.898 -5.893  1.000 23.850 0 420  ASN A N   1 ? 
ATOM   3120 C CA  . ASN A 1 416 ? 59.687  -53.340 -7.277  1.000 22.621 0 420  ASN A CA  1 ? 
ATOM   3121 C C   . ASN A 1 416 ? 59.337  -54.822 -7.346  1.000 23.484 0 420  ASN A C   1 ? 
ATOM   3122 O O   . ASN A 1 416 ? 58.415  -55.222 -8.066  1.000 23.569 0 420  ASN A O   1 ? 
ATOM   3123 C CB  . ASN A 1 416 ? 60.962  -53.071 -8.088  1.000 25.021 0 420  ASN A CB  1 ? 
ATOM   3124 C CG  . ASN A 1 416 ? 61.187  -51.602 -8.348  1.000 31.404 0 420  ASN A CG  1 ? 
ATOM   3125 O OD1 . ASN A 1 416 ? 60.250  -50.819 -8.364  1.000 32.970 0 420  ASN A OD1 1 ? 
ATOM   3126 N ND2 . ASN A 1 416 ? 62.441  -51.221 -8.564  1.000 36.333 0 420  ASN A ND2 1 ? 
ATOM   3127 N N   . GLU A 1 417 ? 60.078  -55.662 -6.609  1.000 24.282 0 421  GLU A N   1 ? 
ATOM   3128 C CA  . GLU A 1 417 ? 59.823  -57.098 -6.701  1.000 22.545 0 421  GLU A CA  1 ? 
ATOM   3129 C C   . GLU A 1 417 ? 58.478  -57.477 -6.101  1.000 22.118 0 421  GLU A C   1 ? 
ATOM   3130 O O   . GLU A 1 417 ? 57.849  -58.432 -6.572  1.000 22.468 0 421  GLU A O   1 ? 
ATOM   3131 C CB  . GLU A 1 417 ? 60.957  -57.895 -6.032  1.000 22.408 0 421  GLU A CB  1 ? 
ATOM   3132 C CG  . GLU A 1 417 ? 61.076  -57.697 -4.531  1.000 22.816 0 421  GLU A CG  1 ? 
ATOM   3133 C CD  . GLU A 1 417 ? 62.180  -58.547 -3.911  1.000 27.337 0 421  GLU A CD  1 ? 
ATOM   3134 O OE1 . GLU A 1 417 ? 63.037  -59.057 -4.657  1.000 29.040 0 421  GLU A OE1 1 ? 
ATOM   3135 O OE2 . GLU A 1 417 ? 62.177  -58.701 -2.669  1.000 28.098 0 421  GLU A OE2 1 ? 
ATOM   3136 N N   . GLN A 1 418 ? 58.010  -56.747 -5.081  1.000 20.739 0 422  GLN A N   1 ? 
ATOM   3137 C CA  . GLN A 1 418 ? 56.711  -57.059 -4.496  1.000 20.487 0 422  GLN A CA  1 ? 
ATOM   3138 C C   . GLN A 1 418 ? 55.580  -56.652 -5.426  1.000 22.726 0 422  GLN A C   1 ? 
ATOM   3139 O O   . GLN A 1 418 ? 54.570  -57.357 -5.530  1.000 20.963 0 422  GLN A O   1 ? 
ATOM   3140 C CB  . GLN A 1 418 ? 56.557  -56.365 -3.147  1.000 20.400 0 422  GLN A CB  1 ? 
ATOM   3141 C CG  . GLN A 1 418 ? 57.421  -56.990 -2.065  1.000 22.621 0 422  GLN A CG  1 ? 
ATOM   3142 C CD  . GLN A 1 418 ? 57.420  -56.157 -0.802  1.000 25.369 0 422  GLN A CD  1 ? 
ATOM   3143 O OE1 . GLN A 1 418 ? 57.169  -54.955 -0.852  1.000 24.540 0 422  GLN A OE1 1 ? 
ATOM   3144 N NE2 . GLN A 1 418 ? 57.696  -56.789 0.336   1.000 23.566 0 422  GLN A NE2 1 ? 
ATOM   3145 N N   . ALA A 1 419 ? 55.726  -55.509 -6.100  1.000 22.395 0 423  ALA A N   1 ? 
ATOM   3146 C CA  . ALA A 1 419 ? 54.725  -55.115 -7.084  1.000 23.779 0 423  ALA A CA  1 ? 
ATOM   3147 C C   . ALA A 1 419 ? 54.658  -56.131 -8.213  1.000 23.848 0 423  ALA A C   1 ? 
ATOM   3148 O O   . ALA A 1 419 ? 53.568  -56.544 -8.625  1.000 25.524 0 423  ALA A O   1 ? 
ATOM   3149 C CB  . ALA A 1 419 ? 55.041  -53.719 -7.624  1.000 24.345 0 423  ALA A CB  1 ? 
ATOM   3150 N N   . ASP A 1 420 ? 55.819  -56.583 -8.693  1.000 22.350 0 424  ASP A N   1 ? 
ATOM   3151 C CA  . ASP A 1 420 ? 55.842  -57.616 -9.727  1.000 23.548 0 424  ASP A CA  1 ? 
ATOM   3152 C C   . ASP A 1 420 ? 55.249  -58.925 -9.221  1.000 25.145 0 424  ASP A C   1 ? 
ATOM   3153 O O   . ASP A 1 420 ? 54.548  -59.622 -9.964  1.000 24.019 0 424  ASP A O   1 ? 
ATOM   3154 C CB  . ASP A 1 420 ? 57.273  -57.833 -10.211 1.000 24.690 0 424  ASP A CB  1 ? 
ATOM   3155 C CG  . ASP A 1 420 ? 57.796  -56.667 -11.037 1.000 32.457 0 424  ASP A CG  1 ? 
ATOM   3156 O OD1 . ASP A 1 420 ? 56.982  -55.821 -11.478 1.000 33.570 0 424  ASP A OD1 1 ? 
ATOM   3157 O OD2 . ASP A 1 420 ? 59.026  -56.598 -11.241 1.000 30.970 0 424  ASP A OD2 1 ? 
ATOM   3158 N N   . TYR A 1 421 ? 55.524  -59.281 -7.961  1.000 21.861 0 425  TYR A N   1 ? 
ATOM   3159 C CA  . TYR A 1 421 ? 55.095  -60.581 -7.447  1.000 22.163 0 425  TYR A CA  1 ? 
ATOM   3160 C C   . TYR A 1 421 ? 53.576  -60.727 -7.475  1.000 23.805 0 425  TYR A C   1 ? 
ATOM   3161 O O   . TYR A 1 421 ? 53.050  -61.801 -7.806  1.000 23.148 0 425  TYR A O   1 ? 
ATOM   3162 C CB  . TYR A 1 421 ? 55.613  -60.776 -6.020  1.000 22.590 0 425  TYR A CB  1 ? 
ATOM   3163 C CG  . TYR A 1 421 ? 55.403  -62.166 -5.463  1.000 20.263 0 425  TYR A CG  1 ? 
ATOM   3164 C CD1 . TYR A 1 421 ? 56.317  -63.187 -5.719  1.000 25.393 0 425  TYR A CD1 1 ? 
ATOM   3165 C CD2 . TYR A 1 421 ? 54.299  -62.451 -4.660  1.000 22.611 0 425  TYR A CD2 1 ? 
ATOM   3166 C CE1 . TYR A 1 421 ? 56.133  -64.462 -5.191  1.000 26.174 0 425  TYR A CE1 1 ? 
ATOM   3167 C CE2 . TYR A 1 421 ? 54.099  -63.717 -4.136  1.000 26.143 0 425  TYR A CE2 1 ? 
ATOM   3168 C CZ  . TYR A 1 421 ? 55.019  -64.715 -4.402  1.000 26.598 0 425  TYR A CZ  1 ? 
ATOM   3169 O OH  . TYR A 1 421 ? 54.807  -65.968 -3.879  1.000 30.880 0 425  TYR A OH  1 ? 
ATOM   3170 N N   . ILE A 1 422 ? 52.848  -59.665 -7.123  1.000 23.016 0 426  ILE A N   1 ? 
ATOM   3171 C CA  . ILE A 1 422 ? 51.387  -59.722 -7.132  1.000 21.339 0 426  ILE A CA  1 ? 
ATOM   3172 C C   . ILE A 1 422 ? 50.777  -59.133 -8.395  1.000 26.006 0 426  ILE A C   1 ? 
ATOM   3173 O O   . ILE A 1 422 ? 49.540  -59.115 -8.527  1.000 27.638 0 426  ILE A O   1 ? 
ATOM   3174 C CB  . ILE A 1 422 ? 50.803  -59.044 -5.875  1.000 21.258 0 426  ILE A CB  1 ? 
ATOM   3175 C CG1 . ILE A 1 422 ? 51.124  -57.547 -5.848  1.000 21.068 0 426  ILE A CG1 1 ? 
ATOM   3176 C CG2 . ILE A 1 422 ? 51.362  -59.714 -4.611  1.000 22.721 0 426  ILE A CG2 1 ? 
ATOM   3177 C CD1 . ILE A 1 422 ? 50.372  -56.800 -4.715  1.000 22.366 0 426  ILE A CD1 1 ? 
ATOM   3178 N N   . GLY A 1 423 ? 51.596  -58.659 -9.328  1.000 24.477 0 427  GLY A N   1 ? 
ATOM   3179 C CA  . GLY A 1 423 ? 51.114  -58.228 -10.626 1.000 26.577 0 427  GLY A CA  1 ? 
ATOM   3180 C C   . GLY A 1 423 ? 50.473  -56.858 -10.656 1.000 27.243 0 427  GLY A C   1 ? 
ATOM   3181 O O   . GLY A 1 423 ? 49.470  -56.664 -11.356 1.000 28.861 0 427  GLY A O   1 ? 
ATOM   3182 N N   . VAL A 1 424 ? 51.018  -55.893 -9.914  1.000 25.224 0 428  VAL A N   1 ? 
ATOM   3183 C CA  . VAL A 1 424 ? 50.454  -54.551 -9.868  1.000 22.674 0 428  VAL A CA  1 ? 
ATOM   3184 C C   . VAL A 1 424 ? 51.547  -53.521 -10.106 1.000 23.853 0 428  VAL A C   1 ? 
ATOM   3185 O O   . VAL A 1 424 ? 52.742  -53.781 -9.935  1.000 25.621 0 428  VAL A O   1 ? 
ATOM   3186 C CB  . VAL A 1 424 ? 49.751  -54.246 -8.529  1.000 22.669 0 428  VAL A CB  1 ? 
ATOM   3187 C CG1 . VAL A 1 424 ? 48.668  -55.280 -8.242  1.000 22.268 0 428  VAL A CG1 1 ? 
ATOM   3188 C CG2 . VAL A 1 424 ? 50.772  -54.202 -7.396  1.000 21.713 0 428  VAL A CG2 1 ? 
ATOM   3189 N N   . ASP A 1 425 ? 51.108  -52.331 -10.499 1.000 23.692 0 429  ASP A N   1 ? 
ATOM   3190 C CA  . ASP A 1 425 ? 51.965  -51.158 -10.505 1.000 27.356 0 429  ASP A CA  1 ? 
ATOM   3191 C C   . ASP A 1 425 ? 52.153  -50.665 -9.073  1.000 24.932 0 429  ASP A C   1 ? 
ATOM   3192 O O   . ASP A 1 425 ? 51.219  -50.718 -8.268  1.000 24.450 0 429  ASP A O   1 ? 
ATOM   3193 C CB  . ASP A 1 425 ? 51.335  -50.061 -11.366 1.000 31.159 0 429  ASP A CB  1 ? 
ATOM   3194 C CG  . ASP A 1 425 ? 52.293  -48.933 -11.666 1.000 39.199 0 429  ASP A CG  1 ? 
ATOM   3195 O OD1 . ASP A 1 425 ? 52.592  -48.132 -10.753 1.000 38.284 0 429  ASP A OD1 1 ? 
ATOM   3196 O OD2 . ASP A 1 425 ? 52.756  -48.847 -12.824 1.000 49.990 0 429  ASP A OD2 1 ? 
ATOM   3197 N N   . LYS A 1 426 ? 53.365  -50.186 -8.761  1.000 25.348 0 430  LYS A N   1 ? 
ATOM   3198 C CA  . LYS A 1 426 ? 53.653  -49.665 -7.422  1.000 23.553 0 430  LYS A CA  1 ? 
ATOM   3199 C C   . LYS A 1 426 ? 52.665  -48.584 -7.001  1.000 24.258 0 430  LYS A C   1 ? 
ATOM   3200 O O   . LYS A 1 426 ? 52.376  -48.433 -5.807  1.000 25.190 0 430  LYS A O   1 ? 
ATOM   3201 C CB  . LYS A 1 426 ? 55.086  -49.107 -7.373  1.000 28.940 0 430  LYS A CB  1 ? 
ATOM   3202 C CG  . LYS A 1 426 ? 56.058  -50.007 -6.633  1.000 34.925 0 430  LYS A CG  1 ? 
ATOM   3203 C CD  . LYS A 1 426 ? 57.526  -49.814 -7.035  1.000 37.504 0 430  LYS A CD  1 ? 
ATOM   3204 C CE  . LYS A 1 426 ? 57.844  -48.410 -7.487  1.000 41.329 0 430  LYS A CE  1 ? 
ATOM   3205 N NZ  . LYS A 1 426 ? 59.329  -48.267 -7.711  1.000 40.989 0 430  LYS A NZ  1 ? 
ATOM   3206 N N   . ASN A 1 427 ? 52.145  -47.816 -7.955  1.000 25.656 0 431  ASN A N   1 ? 
ATOM   3207 C CA  . ASN A 1 427 ? 51.222  -46.732 -7.663  1.000 25.724 0 431  ASN A CA  1 ? 
ATOM   3208 C C   . ASN A 1 427 ? 49.769  -47.127 -7.864  1.000 24.958 0 431  ASN A C   1 ? 
ATOM   3209 O O   . ASN A 1 427 ? 48.895  -46.255 -7.867  1.000 27.416 0 431  ASN A O   1 ? 
ATOM   3210 C CB  . ASN A 1 427 ? 51.552  -45.516 -8.525  1.000 29.359 0 431  ASN A CB  1 ? 
ATOM   3211 C CG  . ASN A 1 427 ? 52.948  -44.997 -8.271  1.000 33.196 0 431  ASN A CG  1 ? 
ATOM   3212 O OD1 . ASN A 1 427 ? 53.419  -45.000 -7.135  1.000 37.083 0 431  ASN A OD1 1 ? 
ATOM   3213 N ND2 . ASN A 1 427 ? 53.622  -44.560 -9.326  1.000 42.960 0 431  ASN A ND2 1 ? 
ATOM   3214 N N   . GLY A 1 428 ? 49.490  -48.413 -8.049  1.000 22.274 0 432  GLY A N   1 ? 
ATOM   3215 C CA  . GLY A 1 428 ? 48.137  -48.869 -8.243  1.000 20.958 0 432  GLY A CA  1 ? 
ATOM   3216 C C   . GLY A 1 428 ? 47.676  -48.787 -9.687  1.000 23.940 0 432  GLY A C   1 ? 
ATOM   3217 O O   . GLY A 1 428 ? 48.398  -48.310 -10.568 1.000 24.398 0 432  GLY A O   1 ? 
ATOM   3218 N N   . PRO A 1 429 ? 46.453  -49.264 -9.969  1.000 22.229 0 433  PRO A N   1 ? 
ATOM   3219 C CA  . PRO A 1 429 ? 45.507  -49.868 -9.016  1.000 19.613 0 433  PRO A CA  1 ? 
ATOM   3220 C C   . PRO A 1 429 ? 46.003  -51.200 -8.450  1.000 22.803 0 433  PRO A C   1 ? 
ATOM   3221 O O   . PRO A 1 429 ? 46.773  -51.902 -9.114  1.000 24.813 0 433  PRO A O   1 ? 
ATOM   3222 C CB  . PRO A 1 429 ? 44.244  -50.063 -9.859  1.000 24.911 0 433  PRO A CB  1 ? 
ATOM   3223 C CG  . PRO A 1 429 ? 44.750  -50.231 -11.253 1.000 27.674 0 433  PRO A CG  1 ? 
ATOM   3224 C CD  . PRO A 1 429 ? 45.960  -49.328 -11.355 1.000 23.319 0 433  PRO A CD  1 ? 
ATOM   3225 N N   . TYR A 1 430 ? 45.591  -51.522 -7.220  1.000 20.145 0 434  TYR A N   1 ? 
ATOM   3226 C CA  . TYR A 1 430 ? 46.176  -52.638 -6.491  1.000 19.679 0 434  TYR A CA  1 ? 
ATOM   3227 C C   . TYR A 1 430 ? 45.330  -53.898 -6.509  1.000 19.576 0 434  TYR A C   1 ? 
ATOM   3228 O O   . TYR A 1 430 ? 45.821  -54.950 -6.071  1.000 20.437 0 434  TYR A O   1 ? 
ATOM   3229 C CB  . TYR A 1 430 ? 46.430  -52.243 -5.034  1.000 19.242 0 434  TYR A CB  1 ? 
ATOM   3230 C CG  . TYR A 1 430 ? 47.362  -51.081 -4.923  1.000 19.131 0 434  TYR A CG  1 ? 
ATOM   3231 C CD1 . TYR A 1 430 ? 48.709  -51.216 -5.242  1.000 19.597 0 434  TYR A CD1 1 ? 
ATOM   3232 C CD2 . TYR A 1 430 ? 46.902  -49.847 -4.494  1.000 20.208 0 434  TYR A CD2 1 ? 
ATOM   3233 C CE1 . TYR A 1 430 ? 49.576  -50.134 -5.154  1.000 22.411 0 434  TYR A CE1 1 ? 
ATOM   3234 C CE2 . TYR A 1 430 ? 47.752  -48.768 -4.398  1.000 21.005 0 434  TYR A CE2 1 ? 
ATOM   3235 C CZ  . TYR A 1 430 ? 49.090  -48.918 -4.730  1.000 23.069 0 434  TYR A CZ  1 ? 
ATOM   3236 O OH  . TYR A 1 430 ? 49.939  -47.843 -4.631  1.000 23.561 0 434  TYR A OH  1 ? 
ATOM   3237 N N   . LYS A 1 431 ? 44.093  -53.824 -6.997  1.000 18.284 0 435  LYS A N   1 ? 
ATOM   3238 C CA  . LYS A 1 431 ? 43.148  -54.929 -6.949  1.000 18.950 0 435  LYS A CA  1 ? 
ATOM   3239 C C   . LYS A 1 431 ? 42.542  -55.168 -8.323  1.000 22.516 0 435  LYS A C   1 ? 
ATOM   3240 O O   . LYS A 1 431 ? 42.400  -54.233 -9.113  1.000 21.371 0 435  LYS A O   1 ? 
ATOM   3241 C CB  . LYS A 1 431 ? 42.005  -54.648 -5.953  1.000 17.726 0 435  LYS A CB  1 ? 
ATOM   3242 C CG  . LYS A 1 431 ? 42.478  -54.501 -4.511  1.000 19.337 0 435  LYS A CG  1 ? 
ATOM   3243 C CD  . LYS A 1 431 ? 43.056  -55.802 -3.968  1.000 19.021 0 435  LYS A CD  1 ? 
ATOM   3244 C CE  . LYS A 1 431 ? 43.286  -55.706 -2.461  1.000 19.084 0 435  LYS A CE  1 ? 
ATOM   3245 N NZ  . LYS A 1 431 ? 44.429  -54.795 -2.098  1.000 18.626 0 435  LYS A NZ  1 ? 
ATOM   3246 N N   . PRO A 1 432 ? 42.152  -56.406 -8.621  1.000 22.603 0 436  PRO A N   1 ? 
ATOM   3247 C CA  . PRO A 1 432 ? 41.408  -56.671 -9.859  1.000 23.932 0 436  PRO A CA  1 ? 
ATOM   3248 C C   . PRO A 1 432 ? 40.107  -55.882 -9.909  1.000 24.669 0 436  PRO A C   1 ? 
ATOM   3249 O O   . PRO A 1 432 ? 39.544  -55.492 -8.881  1.000 21.616 0 436  PRO A O   1 ? 
ATOM   3250 C CB  . PRO A 1 432 ? 41.134  -58.181 -9.800  1.000 28.864 0 436  PRO A CB  1 ? 
ATOM   3251 C CG  . PRO A 1 432 ? 42.110  -58.730 -8.817  1.000 30.893 0 436  PRO A CG  1 ? 
ATOM   3252 C CD  . PRO A 1 432 ? 42.364  -57.625 -7.820  1.000 27.701 0 436  PRO A CD  1 ? 
ATOM   3253 N N   . ASP A 1 433 ? 39.611  -55.680 -11.140 1.000 24.821 0 437  ASP A N   1 ? 
ATOM   3254 C CA  . ASP A 1 433 ? 38.452  -54.808 -11.357 1.000 26.545 0 437  ASP A CA  1 ? 
ATOM   3255 C C   . ASP A 1 433 ? 37.259  -55.180 -10.478 1.000 26.090 0 437  ASP A C   1 ? 
ATOM   3256 O O   . ASP A 1 433 ? 36.541  -54.301 -9.994  1.000 31.822 0 437  ASP A O   1 ? 
ATOM   3257 C CB  . ASP A 1 433 ? 38.017  -54.846 -12.826 1.000 33.054 0 437  ASP A CB  1 ? 
ATOM   3258 C CG  . ASP A 1 433 ? 39.130  -54.461 -13.784 1.000 49.106 0 437  ASP A CG  1 ? 
ATOM   3259 O OD1 . ASP A 1 433 ? 40.058  -53.735 -13.367 1.000 52.372 0 437  ASP A OD1 1 ? 
ATOM   3260 O OD2 . ASP A 1 433 ? 39.069  -54.883 -14.961 1.000 55.180 0 437  ASP A OD2 1 ? 
ATOM   3261 N N   . HIS A 1 434 ? 37.021  -56.472 -10.273 1.000 23.045 0 438  HIS A N   1 ? 
ATOM   3262 C CA  . HIS A 1 434 ? 35.829  -56.919 -9.559  1.000 27.835 0 438  HIS A CA  1 ? 
ATOM   3263 C C   . HIS A 1 434 ? 36.126  -57.361 -8.130  1.000 25.587 0 438  HIS A C   1 ? 
ATOM   3264 O O   . HIS A 1 434 ? 35.308  -58.056 -7.512  1.000 24.787 0 438  HIS A O   1 ? 
ATOM   3265 C CB  . HIS A 1 434 ? 35.150  -58.034 -10.348 1.000 29.561 0 438  HIS A CB  1 ? 
ATOM   3266 C CG  . HIS A 1 434 ? 34.840  -57.646 -11.758 1.000 35.828 0 438  HIS A CG  1 ? 
ATOM   3267 N ND1 . HIS A 1 434 ? 34.457  -56.367 -12.104 1.000 37.260 0 438  HIS A ND1 1 ? 
ATOM   3268 C CD2 . HIS A 1 434 ? 34.888  -58.351 -12.913 1.000 38.307 0 438  HIS A CD2 1 ? 
ATOM   3269 C CE1 . HIS A 1 434 ? 34.272  -56.304 -13.411 1.000 38.491 0 438  HIS A CE1 1 ? 
ATOM   3270 N NE2 . HIS A 1 434 ? 34.523  -57.495 -13.924 1.000 40.897 0 438  HIS A NE2 1 ? 
ATOM   3271 N N   . TYR A 1 435 ? 37.274  -56.963 -7.590  1.000 20.997 0 439  TYR A N   1 ? 
ATOM   3272 C CA  . TYR A 1 435 ? 37.570  -57.232 -6.193  1.000 17.897 0 439  TYR A CA  1 ? 
ATOM   3273 C C   . TYR A 1 435 ? 36.498  -56.598 -5.313  1.000 19.139 0 439  TYR A C   1 ? 
ATOM   3274 O O   . TYR A 1 435 ? 36.013  -55.498 -5.597  1.000 20.037 0 439  TYR A O   1 ? 
ATOM   3275 C CB  . TYR A 1 435 ? 38.957  -56.674 -5.860  1.000 16.881 0 439  TYR A CB  1 ? 
ATOM   3276 C CG  . TYR A 1 435 ? 39.458  -57.013 -4.471  1.000 19.452 0 439  TYR A CG  1 ? 
ATOM   3277 C CD1 . TYR A 1 435 ? 39.979  -58.272 -4.181  1.000 18.679 0 439  TYR A CD1 1 ? 
ATOM   3278 C CD2 . TYR A 1 435 ? 39.423  -56.062 -3.458  1.000 17.657 0 439  TYR A CD2 1 ? 
ATOM   3279 C CE1 . TYR A 1 435 ? 40.451  -58.576 -2.905  1.000 17.968 0 439  TYR A CE1 1 ? 
ATOM   3280 C CE2 . TYR A 1 435 ? 39.883  -56.353 -2.177  1.000 16.536 0 439  TYR A CE2 1 ? 
ATOM   3281 C CZ  . TYR A 1 435 ? 40.399  -57.610 -1.916  1.000 17.452 0 439  TYR A CZ  1 ? 
ATOM   3282 O OH  . TYR A 1 435 ? 40.862  -57.907 -0.656  1.000 20.187 0 439  TYR A OH  1 ? 
ATOM   3283 N N   . ARG A 1 436 ? 36.122  -57.299 -4.234  1.000 17.376 0 440  ARG A N   1 ? 
ATOM   3284 C CA  . ARG A 1 436 ? 34.956  -56.899 -3.457  1.000 17.218 0 440  ARG A CA  1 ? 
ATOM   3285 C C   . ARG A 1 436 ? 35.287  -56.203 -2.141  1.000 17.242 0 440  ARG A C   1 ? 
ATOM   3286 O O   . ARG A 1 436 ? 34.370  -55.648 -1.518  1.000 18.113 0 440  ARG A O   1 ? 
ATOM   3287 C CB  . ARG A 1 436 ? 34.062  -58.119 -3.189  1.000 18.247 0 440  ARG A CB  1 ? 
ATOM   3288 C CG  . ARG A 1 436 ? 33.483  -58.710 -4.485  1.000 17.747 0 440  ARG A CG  1 ? 
ATOM   3289 C CD  . ARG A 1 436 ? 32.374  -59.706 -4.176  1.000 18.455 0 440  ARG A CD  1 ? 
ATOM   3290 N NE  . ARG A 1 436 ? 31.679  -60.129 -5.390  1.000 18.013 0 440  ARG A NE  1 ? 
ATOM   3291 C CZ  . ARG A 1 436 ? 31.987  -61.219 -6.093  1.000 20.910 0 440  ARG A CZ  1 ? 
ATOM   3292 N NH1 . ARG A 1 436 ? 33.002  -62.002 -5.711  1.000 20.263 0 440  ARG A NH1 1 ? 
ATOM   3293 N NH2 . ARG A 1 436 ? 31.273  -61.543 -7.169  1.000 21.379 0 440  ARG A NH2 1 ? 
ATOM   3294 N N   . TYR A 1 437 ? 36.560  -56.175 -1.730  1.000 17.997 0 441  TYR A N   1 ? 
ATOM   3295 C CA  . TYR A 1 437 ? 36.979  -55.549 -0.463  1.000 19.268 0 441  TYR A CA  1 ? 
ATOM   3296 C C   . TYR A 1 437 ? 36.191  -56.093 0.727   1.000 21.745 0 441  TYR A C   1 ? 
ATOM   3297 O O   . TYR A 1 437 ? 35.704  -57.236 0.663   1.000 20.681 0 441  TYR A O   1 ? 
ATOM   3298 C CB  . TYR A 1 437 ? 36.847  -54.016 -0.542  1.000 16.855 0 441  TYR A CB  1 ? 
ATOM   3299 C CG  . TYR A 1 437 ? 37.645  -53.436 -1.690  1.000 15.855 0 441  TYR A CG  1 ? 
ATOM   3300 C CD1 . TYR A 1 437 ? 37.106  -53.371 -2.974  1.000 18.729 0 441  TYR A CD1 1 ? 
ATOM   3301 C CD2 . TYR A 1 437 ? 38.948  -52.979 -1.492  1.000 16.165 0 441  TYR A CD2 1 ? 
ATOM   3302 C CE1 . TYR A 1 437 ? 37.838  -52.860 -4.039  1.000 18.492 0 441  TYR A CE1 1 ? 
ATOM   3303 C CE2 . TYR A 1 437 ? 39.694  -52.474 -2.557  1.000 17.086 0 441  TYR A CE2 1 ? 
ATOM   3304 C CZ  . TYR A 1 437 ? 39.128  -52.415 -3.822  1.000 17.863 0 441  TYR A CZ  1 ? 
ATOM   3305 O OH  . TYR A 1 437 ? 39.838  -51.906 -4.895  1.000 19.252 0 441  TYR A OH  1 ? 
ATOM   3306 O OXT . TYR A 1 437 ? 36.033  -55.418 1.761   1.000 17.678 0 441  TYR A OXT 1 ? 
HETATM 3307 P PA  . NAD B 2 .   ? 21.707  -53.058 -0.691  1.000 19.816 0 501  NAD A PA  1 ? 
HETATM 3308 O O1A . NAD B 2 .   ? 21.095  -53.489 -1.969  1.000 22.266 0 501  NAD A O1A 1 ? 
HETATM 3309 O O2A . NAD B 2 .   ? 23.171  -53.221 -0.504  1.000 18.905 0 501  NAD A O2A 1 ? 
HETATM 3310 O O5B . NAD B 2 .   ? 20.958  -53.739 0.538   1.000 17.207 0 501  NAD A O5B 1 ? 
HETATM 3311 C C5B . NAD B 2 .   ? 19.533  -53.905 0.537   1.000 14.936 0 501  NAD A C5B 1 ? 
HETATM 3312 C C4B . NAD B 2 .   ? 19.249  -55.311 0.990   1.000 20.402 0 501  NAD A C4B 1 ? 
HETATM 3313 O O4B . NAD B 2 .   ? 17.833  -55.464 1.239   1.000 17.784 0 501  NAD A O4B 1 ? 
HETATM 3314 C C3B . NAD B 2 .   ? 19.632  -56.404 -0.021  1.000 34.228 0 501  NAD A C3B 1 ? 
HETATM 3315 O O3B . NAD B 2 .   ? 20.628  -57.275 0.494   1.000 19.568 0 501  NAD A O3B 1 ? 
HETATM 3316 C C2B . NAD B 2 .   ? 18.316  -57.143 -0.296  1.000 21.421 0 501  NAD A C2B 1 ? 
HETATM 3317 O O2B . NAD B 2 .   ? 18.476  -58.537 -0.430  1.000 17.042 0 501  NAD A O2B 1 ? 
HETATM 3318 C C1B . NAD B 2 .   ? 17.495  -56.790 0.937   1.000 17.099 0 501  NAD A C1B 1 ? 
HETATM 3319 N N9A . NAD B 2 .   ? 16.058  -56.866 0.733   1.000 16.255 0 501  NAD A N9A 1 ? 
HETATM 3320 C C8A . NAD B 2 .   ? 15.349  -56.431 -0.356  1.000 18.010 0 501  NAD A C8A 1 ? 
HETATM 3321 N N7A . NAD B 2 .   ? 14.062  -56.629 -0.246  1.000 18.073 0 501  NAD A N7A 1 ? 
HETATM 3322 C C5A . NAD B 2 .   ? 13.912  -57.223 0.996   1.000 18.171 0 501  NAD A C5A 1 ? 
HETATM 3323 C C6A . NAD B 2 .   ? 12.784  -57.678 1.700   1.000 19.181 0 501  NAD A C6A 1 ? 
HETATM 3324 N N6A . NAD B 2 .   ? 11.543  -57.608 1.230   1.000 20.655 0 501  NAD A N6A 1 ? 
HETATM 3325 N N1A . NAD B 2 .   ? 12.988  -58.222 2.920   1.000 19.250 0 501  NAD A N1A 1 ? 
HETATM 3326 C C2A . NAD B 2 .   ? 14.237  -58.302 3.387   1.000 17.786 0 501  NAD A C2A 1 ? 
HETATM 3327 N N3A . NAD B 2 .   ? 15.367  -57.913 2.813   1.000 19.255 0 501  NAD A N3A 1 ? 
HETATM 3328 C C4A . NAD B 2 .   ? 15.138  -57.376 1.609   1.000 18.700 0 501  NAD A C4A 1 ? 
HETATM 3329 O O3  . NAD B 2 .   ? 21.368  -51.527 -0.439  1.000 18.436 0 501  NAD A O3  1 ? 
HETATM 3330 P PN  . NAD B 2 .   ? 21.999  -50.558 0.655   1.000 18.165 0 501  NAD A PN  1 ? 
HETATM 3331 O O1N . NAD B 2 .   ? 23.224  -49.921 0.110   1.000 19.276 0 501  NAD A O1N 1 ? 
HETATM 3332 O O2N . NAD B 2 .   ? 22.110  -51.295 1.936   1.000 18.805 0 501  NAD A O2N 1 ? 
HETATM 3333 O O5D . NAD B 2 .   ? 20.872  -49.446 0.774   1.000 17.850 0 501  NAD A O5D 1 ? 
HETATM 3334 C C5D . NAD B 2 .   ? 19.590  -49.772 1.328   1.000 17.299 0 501  NAD A C5D 1 ? 
HETATM 3335 C C4D . NAD B 2 .   ? 18.710  -48.552 1.240   1.000 18.034 0 501  NAD A C4D 1 ? 
HETATM 3336 O O4D . NAD B 2 .   ? 19.249  -47.500 2.064   1.000 19.137 0 501  NAD A O4D 1 ? 
HETATM 3337 C C3D . NAD B 2 .   ? 18.561  -47.932 -0.155  1.000 23.579 0 501  NAD A C3D 1 ? 
HETATM 3338 O O3D . NAD B 2 .   ? 17.274  -47.355 -0.294  1.000 18.784 0 501  NAD A O3D 1 ? 
HETATM 3339 C C2D . NAD B 2 .   ? 19.639  -46.844 -0.160  1.000 31.714 0 501  NAD A C2D 1 ? 
HETATM 3340 O O2D . NAD B 2 .   ? 19.358  -45.846 -1.125  1.000 20.876 0 501  NAD A O2D 1 ? 
HETATM 3341 C C1D . NAD B 2 .   ? 19.486  -46.340 1.276   1.000 26.795 0 501  NAD A C1D 1 ? 
HETATM 3342 N N1N . NAD B 2 .   ? 20.656  -45.664 1.860   1.000 19.913 0 501  NAD A N1N 1 ? 
HETATM 3343 C C2N . NAD B 2 .   ? 20.487  -44.896 2.985   1.000 19.202 0 501  NAD A C2N 1 ? 
HETATM 3344 C C3N . NAD B 2 .   ? 21.572  -44.266 3.575   1.000 17.270 0 501  NAD A C3N 1 ? 
HETATM 3345 C C7N . NAD B 2 .   ? 21.321  -43.422 4.786   1.000 20.339 0 501  NAD A C7N 1 ? 
HETATM 3346 O O7N . NAD B 2 .   ? 22.166  -42.599 5.153   1.000 21.987 0 501  NAD A O7N 1 ? 
HETATM 3347 N N7N . NAD B 2 .   ? 20.179  -43.591 5.433   1.000 20.729 0 501  NAD A N7N 1 ? 
HETATM 3348 C C4N . NAD B 2 .   ? 22.835  -44.433 3.031   1.000 19.310 0 501  NAD A C4N 1 ? 
HETATM 3349 C C5N . NAD B 2 .   ? 22.996  -45.224 1.911   1.000 19.850 0 501  NAD A C5N 1 ? 
HETATM 3350 C C6N . NAD B 2 .   ? 21.909  -45.844 1.334   1.000 20.413 0 501  NAD A C6N 1 ? 
HETATM 3351 N N9  . ADE C 3 .   ? 23.363  -38.800 3.702   0.350 36.844 0 502  ADE A N9  1 ? 
HETATM 3352 C C8  . ADE C 3 .   ? 23.594  -39.378 4.915   0.000 33.454 0 502  ADE A C8  1 ? 
HETATM 3353 N N7  . ADE C 3 .   ? 24.150  -38.572 5.787   1.000 32.322 0 502  ADE A N7  1 ? 
HETATM 3354 C C5  . ADE C 3 .   ? 24.289  -37.377 5.106   1.000 33.549 0 502  ADE A C5  1 ? 
HETATM 3355 C C6  . ADE C 3 .   ? 24.814  -36.112 5.480   0.400 26.414 0 502  ADE A C6  1 ? 
HETATM 3356 N N6  . ADE C 3 .   ? 25.317  -35.832 6.701   1.000 26.972 0 502  ADE A N6  1 ? 
HETATM 3357 N N1  . ADE C 3 .   ? 24.807  -35.141 4.543   1.000 30.883 0 502  ADE A N1  1 ? 
HETATM 3358 C C2  . ADE C 3 .   ? 24.301  -35.416 3.335   1.000 37.818 0 502  ADE A C2  1 ? 
HETATM 3359 N N3  . ADE C 3 .   ? 23.784  -36.556 2.875   1.000 30.156 0 502  ADE A N3  1 ? 
HETATM 3360 C C4  . ADE C 3 .   ? 23.804  -37.500 3.816   1.000 32.322 0 502  ADE A C4  1 ? 
HETATM 3361 S S   . SO4 D 4 .   ? 20.160  -41.838 1.069   1.000 22.905 0 503  SO4 A S   1 ? 
HETATM 3362 O O1  . SO4 D 4 .   ? 21.367  -42.441 0.504   1.000 24.577 0 503  SO4 A O1  1 ? 
HETATM 3363 O O2  . SO4 D 4 .   ? 19.764  -40.663 0.295   1.000 24.385 0 503  SO4 A O2  1 ? 
HETATM 3364 O O3  . SO4 D 4 .   ? 19.061  -42.821 1.043   1.000 23.753 0 503  SO4 A O3  1 ? 
HETATM 3365 O O4  . SO4 D 4 .   ? 20.468  -41.460 2.439   1.000 23.137 0 503  SO4 A O4  1 ? 
HETATM 3366 S S   . SO4 E 4 .   ? 26.951  -25.717 -22.603 1.000 84.913 0 504  SO4 A S   1 ? 
HETATM 3367 O O1  . SO4 E 4 .   ? 28.243  -26.364 -22.386 1.000 83.860 0 504  SO4 A O1  1 ? 
HETATM 3368 O O2  . SO4 E 4 .   ? 26.475  -26.040 -23.945 1.000 88.866 0 504  SO4 A O2  1 ? 
HETATM 3369 O O3  . SO4 E 4 .   ? 25.988  -26.205 -21.621 1.000 83.044 0 504  SO4 A O3  1 ? 
HETATM 3370 O O4  . SO4 E 4 .   ? 27.093  -24.268 -22.469 1.000 84.810 0 504  SO4 A O4  1 ? 
HETATM 3371 O O   . HOH F 5 .   ? 14.495  -44.353 19.981  1.000 42.134 0 601  HOH A O   1 ? 
HETATM 3372 O O   . HOH F 5 .   ? 32.705  -56.647 0.419   0.500 36.204 0 602  HOH A O   1 ? 
HETATM 3373 O O   . HOH F 5 .   ? 54.261  -46.055 -3.872  1.000 57.807 0 603  HOH A O   1 ? 
HETATM 3374 O O   . HOH F 5 .   ? 25.649  -40.179 0.606   1.000 29.425 0 604  HOH A O   1 ? 
HETATM 3375 O O   . HOH F 5 .   ? 39.300  -51.819 -12.230 1.000 48.043 0 605  HOH A O   1 ? 
HETATM 3376 O O   . HOH F 5 .   ? 20.935  -16.338 -13.656 1.000 59.091 0 606  HOH A O   1 ? 
HETATM 3377 O O   . HOH F 5 .   ? 30.443  -60.746 13.811  1.000 32.583 0 607  HOH A O   1 ? 
HETATM 3378 O O   . HOH F 5 .   ? -0.197  -28.938 -1.097  1.000 60.739 0 608  HOH A O   1 ? 
HETATM 3379 O O   . HOH F 5 .   ? 5.818   -36.819 -2.933  1.000 38.236 0 609  HOH A O   1 ? 
HETATM 3380 O O   . HOH F 5 .   ? 24.975  -33.340 9.547   1.000 46.113 0 610  HOH A O   1 ? 
HETATM 3381 O O   . HOH F 5 .   ? 32.422  -59.406 9.412   1.000 36.075 0 611  HOH A O   1 ? 
HETATM 3382 O O   . HOH F 5 .   ? -5.960  -43.201 1.646   1.000 47.079 0 612  HOH A O   1 ? 
HETATM 3383 O O   . HOH F 5 .   ? -1.669  -39.041 25.285  1.000 48.601 0 613  HOH A O   1 ? 
HETATM 3384 O O   . HOH F 5 .   ? 14.043  -17.550 -7.867  1.000 68.406 0 614  HOH A O   1 ? 
HETATM 3385 O O   . HOH F 5 .   ? 4.405   -66.529 9.719   1.000 51.327 0 615  HOH A O   1 ? 
HETATM 3386 O O   . HOH F 5 .   ? 28.047  -57.186 12.844  1.000 29.356 0 616  HOH A O   1 ? 
HETATM 3387 O O   . HOH F 5 .   ? 28.919  -50.308 22.693  1.000 49.453 0 617  HOH A O   1 ? 
HETATM 3388 O O   . HOH F 5 .   ? 37.101  -19.272 -14.353 1.000 59.626 0 618  HOH A O   1 ? 
HETATM 3389 O O   . HOH F 5 .   ? 23.826  -42.170 0.029   1.000 27.780 0 619  HOH A O   1 ? 
HETATM 3390 O O   . HOH F 5 .   ? -0.287  -52.614 4.501   1.000 27.456 0 620  HOH A O   1 ? 
HETATM 3391 O O   . HOH F 5 .   ? 17.757  -70.622 14.676  1.000 43.153 0 621  HOH A O   1 ? 
HETATM 3392 O O   . HOH F 5 .   ? 38.076  -37.317 -14.980 1.000 39.336 0 622  HOH A O   1 ? 
HETATM 3393 O O   . HOH F 5 .   ? 15.508  -68.318 11.891  1.000 41.247 0 623  HOH A O   1 ? 
HETATM 3394 O O   . HOH F 5 .   ? 6.611   -39.723 12.911  1.000 28.735 0 624  HOH A O   1 ? 
HETATM 3395 O O   . HOH F 5 .   ? 42.232  -51.120 -4.541  1.000 20.702 0 625  HOH A O   1 ? 
HETATM 3396 O O   . HOH F 5 .   ? 0.497   -63.803 15.228  1.000 42.152 0 626  HOH A O   1 ? 
HETATM 3397 O O   . HOH F 5 .   ? 6.581   -26.633 4.985   1.000 40.726 0 627  HOH A O   1 ? 
HETATM 3398 O O   . HOH F 5 .   ? 33.480  -36.240 11.068  1.000 29.677 0 628  HOH A O   1 ? 
HETATM 3399 O O   . HOH F 5 .   ? 15.689  -13.922 3.288   1.000 56.225 0 629  HOH A O   1 ? 
HETATM 3400 O O   . HOH F 5 .   ? 17.062  -54.077 -22.323 1.000 58.541 0 630  HOH A O   1 ? 
HETATM 3401 O O   . HOH F 5 .   ? 34.213  -44.026 -25.144 1.000 65.229 0 631  HOH A O   1 ? 
HETATM 3402 O O   . HOH F 5 .   ? 12.194  -39.060 27.521  1.000 48.790 0 632  HOH A O   1 ? 
HETATM 3403 O O   . HOH F 5 .   ? 26.230  -35.281 10.414  1.000 48.790 0 633  HOH A O   1 ? 
HETATM 3404 O O   . HOH F 5 .   ? 23.788  -66.845 13.615  1.000 44.458 0 634  HOH A O   1 ? 
HETATM 3405 O O   . HOH F 5 .   ? 46.402  -45.669 -6.435  1.000 29.627 0 635  HOH A O   1 ? 
HETATM 3406 O O   . HOH F 5 .   ? 25.112  -30.189 12.085  1.000 47.885 0 636  HOH A O   1 ? 
HETATM 3407 O O   . HOH F 5 .   ? -1.170  -25.800 -2.692  1.000 58.165 0 637  HOH A O   1 ? 
HETATM 3408 O O   . HOH F 5 .   ? 37.245  -28.597 -17.560 1.000 43.026 0 638  HOH A O   1 ? 
HETATM 3409 O O   . HOH F 5 .   ? -4.529  -39.619 10.532  1.000 48.772 0 639  HOH A O   1 ? 
HETATM 3410 O O   . HOH F 5 .   ? 54.627  -54.721 -11.639 1.000 35.531 0 640  HOH A O   1 ? 
HETATM 3411 O O   . HOH F 5 .   ? 36.422  -53.670 -7.412  1.000 21.689 0 641  HOH A O   1 ? 
HETATM 3412 O O   . HOH F 5 .   ? 25.054  -51.480 -7.817  1.000 38.452 0 642  HOH A O   1 ? 
HETATM 3413 O O   . HOH F 5 .   ? 2.223   -27.249 0.278   1.000 40.231 0 643  HOH A O   1 ? 
HETATM 3414 O O   . HOH F 5 .   ? 14.363  -25.222 -17.451 1.000 47.332 0 644  HOH A O   1 ? 
HETATM 3415 O O   . HOH F 5 .   ? 19.140  -54.700 -3.232  1.000 26.906 0 645  HOH A O   1 ? 
HETATM 3416 O O   . HOH F 5 .   ? 14.428  -35.501 -24.931 1.000 55.641 0 646  HOH A O   1 ? 
HETATM 3417 O O   . HOH F 5 .   ? 30.243  -20.086 -9.682  1.000 55.159 0 647  HOH A O   1 ? 
HETATM 3418 O O   . HOH F 5 .   ? 34.157  -55.948 3.522   1.000 22.826 0 648  HOH A O   1 ? 
HETATM 3419 O O   . HOH F 5 .   ? 7.299   -39.437 -0.012  1.000 35.567 0 649  HOH A O   1 ? 
HETATM 3420 O O   . HOH F 5 .   ? 63.956  -59.621 -0.965  1.000 30.130 0 650  HOH A O   1 ? 
HETATM 3421 O O   . HOH F 5 .   ? 22.227  -38.499 19.520  0.500 47.666 0 651  HOH A O   1 ? 
HETATM 3422 O O   . HOH F 5 .   ? 28.712  -40.133 15.220  1.000 36.246 0 652  HOH A O   1 ? 
HETATM 3423 O O   . HOH F 5 .   ? 29.850  -54.072 2.838   1.000 37.065 0 653  HOH A O   1 ? 
HETATM 3424 O O   . HOH F 5 .   ? 20.691  -16.186 -9.176  1.000 42.116 0 654  HOH A O   1 ? 
HETATM 3425 O O   . HOH F 5 .   ? 8.562   -57.982 5.245   1.000 25.632 0 655  HOH A O   1 ? 
HETATM 3426 O O   . HOH F 5 .   ? 5.737   -63.401 17.041  1.000 38.431 0 656  HOH A O   1 ? 
HETATM 3427 O O   . HOH F 5 .   ? 6.530   -56.121 18.631  1.000 29.843 0 657  HOH A O   1 ? 
HETATM 3428 O O   . HOH F 5 .   ? 17.732  -31.757 9.784   1.000 33.259 0 658  HOH A O   1 ? 
HETATM 3429 O O   . HOH F 5 .   ? 32.785  -25.177 2.737   1.000 29.822 0 659  HOH A O   1 ? 
HETATM 3430 O O   . HOH F 5 .   ? 41.745  -52.976 -11.478 1.000 31.625 0 660  HOH A O   1 ? 
HETATM 3431 O O   . HOH F 5 .   ? 11.103  -60.761 22.312  1.000 35.267 0 661  HOH A O   1 ? 
HETATM 3432 O O   . HOH F 5 .   ? 13.955  -47.483 -2.481  1.000 43.510 0 662  HOH A O   1 ? 
HETATM 3433 O O   . HOH F 5 .   ? 61.180  -57.187 -9.815  1.000 27.756 0 663  HOH A O   1 ? 
HETATM 3434 O O   . HOH F 5 .   ? 38.618  -23.640 -16.567 1.000 42.087 0 664  HOH A O   1 ? 
HETATM 3435 O O   . HOH F 5 .   ? 8.433   -37.638 1.697   1.000 30.254 0 665  HOH A O   1 ? 
HETATM 3436 O O   . HOH F 5 .   ? 37.980  -24.503 9.031   1.000 37.962 0 666  HOH A O   1 ? 
HETATM 3437 O O   . HOH F 5 .   ? 25.043  -28.914 -22.793 1.000 45.879 0 667  HOH A O   1 ? 
HETATM 3438 O O   . HOH F 5 .   ? 13.053  -35.803 15.686  1.000 44.971 0 668  HOH A O   1 ? 
HETATM 3439 O O   . HOH F 5 .   ? 27.508  -18.164 4.214   1.000 37.249 0 669  HOH A O   1 ? 
HETATM 3440 O O   . HOH F 5 .   ? -3.495  -45.450 24.010  1.000 38.399 0 670  HOH A O   1 ? 
HETATM 3441 O O   . HOH F 5 .   ? 64.299  -57.158 -6.029  1.000 25.087 0 671  HOH A O   1 ? 
HETATM 3442 O O   . HOH F 5 .   ? 14.346  -29.033 -1.007  1.000 27.066 0 672  HOH A O   1 ? 
HETATM 3443 O O   . HOH F 5 .   ? 38.518  -31.997 12.910  1.000 29.635 0 673  HOH A O   1 ? 
HETATM 3444 O O   . HOH F 5 .   ? 9.633   -48.511 23.558  1.000 29.888 0 674  HOH A O   1 ? 
HETATM 3445 O O   . HOH F 5 .   ? 14.337  -31.016 3.741   1.000 26.564 0 675  HOH A O   1 ? 
HETATM 3446 O O   . HOH F 5 .   ? 4.178   -41.437 1.334   1.000 37.218 0 676  HOH A O   1 ? 
HETATM 3447 O O   . HOH F 5 .   ? 32.018  -31.811 11.293  1.000 26.190 0 677  HOH A O   1 ? 
HETATM 3448 O O   . HOH F 5 .   ? 4.628   -34.765 6.174   1.000 49.072 0 678  HOH A O   1 ? 
HETATM 3449 O O   . HOH F 5 .   ? -4.270  -60.058 12.104  1.000 45.348 0 679  HOH A O   1 ? 
HETATM 3450 O O   . HOH F 5 .   ? 16.960  -21.734 6.891   1.000 31.656 0 680  HOH A O   1 ? 
HETATM 3451 O O   . HOH F 5 .   ? 17.294  -30.410 -7.665  1.000 40.026 0 681  HOH A O   1 ? 
HETATM 3452 O O   . HOH F 5 .   ? 26.979  -49.882 -11.811 1.000 30.009 0 682  HOH A O   1 ? 
HETATM 3453 O O   . HOH F 5 .   ? 28.442  -59.179 7.831   1.000 28.759 0 683  HOH A O   1 ? 
HETATM 3454 O O   . HOH F 5 .   ? 5.790   -35.490 12.937  1.000 52.338 0 684  HOH A O   1 ? 
HETATM 3455 O O   . HOH F 5 .   ? 8.581   -45.389 -3.635  1.000 39.584 0 685  HOH A O   1 ? 
HETATM 3456 O O   . HOH F 5 .   ? 16.813  -53.824 -2.545  1.000 28.385 0 686  HOH A O   1 ? 
HETATM 3457 O O   . HOH F 5 .   ? 21.755  -26.053 -20.223 1.000 41.102 0 687  HOH A O   1 ? 
HETATM 3458 O O   . HOH F 5 .   ? 57.469  -53.039 1.057   1.000 33.057 0 688  HOH A O   1 ? 
HETATM 3459 O O   . HOH F 5 .   ? 14.374  -63.428 6.394   1.000 20.068 0 689  HOH A O   1 ? 
HETATM 3460 O O   . HOH F 5 .   ? 11.991  -25.497 8.592   1.000 32.049 0 690  HOH A O   1 ? 
HETATM 3461 O O   . HOH F 5 .   ? 36.614  -40.577 -20.352 1.000 55.241 0 691  HOH A O   1 ? 
HETATM 3462 O O   . HOH F 5 .   ? 14.883  -23.949 11.709  1.000 53.343 0 692  HOH A O   1 ? 
HETATM 3463 O O   . HOH F 5 .   ? 39.714  -35.177 -15.869 1.000 44.297 0 693  HOH A O   1 ? 
HETATM 3464 O O   . HOH F 5 .   ? 10.553  -40.659 1.515   1.000 25.411 0 694  HOH A O   1 ? 
HETATM 3465 O O   . HOH F 5 .   ? 1.296   -60.236 9.399   1.000 31.677 0 695  HOH A O   1 ? 
HETATM 3466 O O   . HOH F 5 .   ? 30.113  -47.276 -23.570 1.000 43.821 0 696  HOH A O   1 ? 
HETATM 3467 O O   . HOH F 5 .   ? 30.958  -32.558 -21.851 1.000 40.755 0 697  HOH A O   1 ? 
HETATM 3468 O O   . HOH F 5 .   ? 15.626  -49.538 -4.356  1.000 26.003 0 698  HOH A O   1 ? 
HETATM 3469 O O   . HOH F 5 .   ? 47.216  -59.625 -7.266  1.000 44.261 0 699  HOH A O   1 ? 
HETATM 3470 O O   . HOH F 5 .   ? -8.678  -40.514 2.950   1.000 41.184 0 700  HOH A O   1 ? 
HETATM 3471 O O   . HOH F 5 .   ? 3.987   -23.565 0.326   1.000 56.059 0 701  HOH A O   1 ? 
HETATM 3472 O O   . HOH F 5 .   ? -0.872  -47.560 24.752  1.000 39.057 0 702  HOH A O   1 ? 
HETATM 3473 O O   . HOH F 5 .   ? 14.496  -38.522 -2.969  1.000 25.877 0 703  HOH A O   1 ? 
HETATM 3474 O O   . HOH F 5 .   ? 7.518   -66.413 7.434   1.000 28.603 0 704  HOH A O   1 ? 
HETATM 3475 O O   . HOH F 5 .   ? 13.575  -20.571 -9.140  1.000 47.042 0 705  HOH A O   1 ? 
HETATM 3476 O O   . HOH F 5 .   ? 24.861  -40.443 -24.934 1.000 49.051 0 706  HOH A O   1 ? 
HETATM 3477 O O   . HOH F 5 .   ? 1.639   -57.606 20.193  1.000 40.526 0 707  HOH A O   1 ? 
HETATM 3478 O O   . HOH F 5 .   ? 44.201  -33.881 -4.619  1.000 39.639 0 708  HOH A O   1 ? 
HETATM 3479 O O   . HOH F 5 .   ? 15.978  -23.837 5.290   1.000 29.214 0 709  HOH A O   1 ? 
HETATM 3480 O O   . HOH F 5 .   ? 12.905  -35.680 23.675  1.000 41.060 0 710  HOH A O   1 ? 
HETATM 3481 O O   . HOH F 5 .   ? 48.355  -52.002 -11.300 1.000 26.161 0 711  HOH A O   1 ? 
HETATM 3482 O O   . HOH F 5 .   ? 33.324  -29.340 -21.132 1.000 42.076 0 712  HOH A O   1 ? 
HETATM 3483 O O   . HOH F 5 .   ? 4.262   -56.427 1.315   1.000 26.387 0 713  HOH A O   1 ? 
HETATM 3484 O O   . HOH F 5 .   ? 13.600  -57.049 24.974  1.000 25.274 0 714  HOH A O   1 ? 
HETATM 3485 O O   . HOH F 5 .   ? 19.962  -62.868 16.968  1.000 21.039 0 715  HOH A O   1 ? 
HETATM 3486 O O   . HOH F 5 .   ? -4.399  -51.170 24.932  1.000 51.809 0 716  HOH A O   1 ? 
HETATM 3487 O O   . HOH F 5 .   ? 45.237  -43.415 -7.226  1.000 30.651 0 717  HOH A O   1 ? 
HETATM 3488 O O   . HOH F 5 .   ? -7.893  -51.649 12.577  1.000 49.177 0 718  HOH A O   1 ? 
HETATM 3489 O O   . HOH F 5 .   ? 7.448   -64.192 5.354   1.000 51.448 0 719  HOH A O   1 ? 
HETATM 3490 O O   . HOH F 5 .   ? 19.709  -41.015 -10.854 1.000 23.761 0 720  HOH A O   1 ? 
HETATM 3491 O O   . HOH F 5 .   ? 11.011  -47.911 -0.945  1.000 26.022 0 721  HOH A O   1 ? 
HETATM 3492 O O   . HOH F 5 .   ? 51.003  -63.134 -8.985  1.000 46.595 0 722  HOH A O   1 ? 
HETATM 3493 O O   . HOH F 5 .   ? 16.195  -52.201 27.793  1.000 26.424 0 723  HOH A O   1 ? 
HETATM 3494 O O   . HOH F 5 .   ? -7.953  -42.189 18.725  1.000 38.555 0 724  HOH A O   1 ? 
HETATM 3495 O O   . HOH F 5 .   ? 46.605  -55.836 -3.625  1.000 21.579 0 725  HOH A O   1 ? 
HETATM 3496 O O   . HOH F 5 .   ? 2.159   -39.071 23.092  1.000 33.609 0 726  HOH A O   1 ? 
HETATM 3497 O O   . HOH F 5 .   ? 54.679  -52.640 6.569   1.000 23.169 0 727  HOH A O   1 ? 
HETATM 3498 O O   . HOH F 5 .   ? 22.366  -62.928 18.096  1.000 30.127 0 728  HOH A O   1 ? 
HETATM 3499 O O   . HOH F 5 .   ? 5.310   -65.822 5.978   1.000 47.393 0 729  HOH A O   1 ? 
HETATM 3500 O O   . HOH F 5 .   ? 61.101  -56.504 -1.379  1.000 27.864 0 730  HOH A O   1 ? 
HETATM 3501 O O   . HOH F 5 .   ? 19.385  -33.649 8.602   1.000 28.403 0 731  HOH A O   1 ? 
HETATM 3502 O O   . HOH F 5 .   ? 38.062  -22.602 4.073   1.000 44.140 0 732  HOH A O   1 ? 
HETATM 3503 O O   . HOH F 5 .   ? 10.947  -42.835 -11.854 1.000 31.646 0 733  HOH A O   1 ? 
HETATM 3504 O O   . HOH F 5 .   ? 34.755  -22.348 2.469   1.000 44.879 0 734  HOH A O   1 ? 
HETATM 3505 O O   . HOH F 5 .   ? 55.998  -48.222 -3.950  1.000 39.084 0 735  HOH A O   1 ? 
HETATM 3506 O O   . HOH F 5 .   ? 14.113  -64.943 -1.292  1.000 19.813 0 736  HOH A O   1 ? 
HETATM 3507 O O   . HOH F 5 .   ? 45.960  -31.697 -11.059 1.000 43.271 0 737  HOH A O   1 ? 
HETATM 3508 O O   . HOH F 5 .   ? -6.949  -43.800 16.633  1.000 38.578 0 738  HOH A O   1 ? 
HETATM 3509 O O   . HOH F 5 .   ? 3.840   -58.800 21.861  1.000 33.704 0 739  HOH A O   1 ? 
HETATM 3510 O O   . HOH F 5 .   ? 25.316  -50.369 -1.587  1.000 23.095 0 740  HOH A O   1 ? 
HETATM 3511 O O   . HOH F 5 .   ? 1.529   -58.810 6.698   1.000 34.244 0 741  HOH A O   1 ? 
HETATM 3512 O O   . HOH F 5 .   ? 55.245  -47.501 -10.921 1.000 63.892 0 742  HOH A O   1 ? 
HETATM 3513 O O   . HOH F 5 .   ? 27.060  -56.350 10.521  1.000 24.519 0 743  HOH A O   1 ? 
HETATM 3514 O O   . HOH F 5 .   ? 31.185  -45.979 12.246  1.000 20.587 0 744  HOH A O   1 ? 
HETATM 3515 O O   . HOH F 5 .   ? -6.048  -48.602 6.841   1.000 39.157 0 745  HOH A O   1 ? 
HETATM 3516 O O   . HOH F 5 .   ? 20.775  -52.932 3.681   1.000 16.470 0 746  HOH A O   1 ? 
HETATM 3517 O O   . HOH F 5 .   ? 29.561  -24.655 -20.537 1.000 50.461 0 747  HOH A O   1 ? 
HETATM 3518 O O   . HOH F 5 .   ? 11.922  -43.466 9.900   1.000 21.003 0 748  HOH A O   1 ? 
HETATM 3519 O O   . HOH F 5 .   ? 52.423  -44.892 -4.583  1.000 54.307 0 749  HOH A O   1 ? 
HETATM 3520 O O   . HOH F 5 .   ? 22.961  -16.668 -7.723  1.000 58.528 0 750  HOH A O   1 ? 
HETATM 3521 O O   . HOH F 5 .   ? 16.345  -37.768 -5.659  1.000 28.043 0 751  HOH A O   1 ? 
HETATM 3522 O O   . HOH F 5 .   ? -0.746  -60.684 17.654  1.000 31.025 0 752  HOH A O   1 ? 
HETATM 3523 O O   . HOH F 5 .   ? 30.203  -51.496 -3.972  1.000 22.690 0 753  HOH A O   1 ? 
HETATM 3524 O O   . HOH F 5 .   ? 3.293   -60.074 5.061   1.000 42.713 0 754  HOH A O   1 ? 
HETATM 3525 O O   . HOH F 5 .   ? 13.437  -16.156 -0.464  1.000 44.353 0 755  HOH A O   1 ? 
HETATM 3526 O O   . HOH F 5 .   ? 45.875  -38.212 3.265   1.000 29.246 0 756  HOH A O   1 ? 
HETATM 3527 O O   . HOH F 5 .   ? 35.743  -43.943 -7.295  1.000 33.841 0 757  HOH A O   1 ? 
HETATM 3528 O O   . HOH F 5 .   ? 3.551   -31.985 20.150  1.000 46.358 0 758  HOH A O   1 ? 
HETATM 3529 O O   . HOH F 5 .   ? 10.581  -38.268 -2.723  1.000 29.672 0 759  HOH A O   1 ? 
HETATM 3530 O O   . HOH F 5 .   ? 12.684  -41.288 3.252   1.000 23.998 0 760  HOH A O   1 ? 
HETATM 3531 O O   . HOH F 5 .   ? 25.926  -36.494 -22.769 1.000 40.986 0 761  HOH A O   1 ? 
HETATM 3532 O O   . HOH F 5 .   ? 34.300  -51.340 4.601   1.000 19.465 0 762  HOH A O   1 ? 
HETATM 3533 O O   . HOH F 5 .   ? 13.390  -30.577 -2.824  1.000 29.077 0 763  HOH A O   1 ? 
HETATM 3534 O O   . HOH F 5 .   ? 21.219  -17.474 -2.620  1.000 40.942 0 764  HOH A O   1 ? 
HETATM 3535 O O   . HOH F 5 .   ? 8.262   -39.987 -7.696  1.000 33.891 0 765  HOH A O   1 ? 
HETATM 3536 O O   . HOH F 5 .   ? -9.144  -47.685 22.691  1.000 47.111 0 766  HOH A O   1 ? 
HETATM 3537 O O   . HOH F 5 .   ? 58.983  -43.632 6.896   1.000 50.972 0 767  HOH A O   1 ? 
HETATM 3538 O O   . HOH F 5 .   ? 34.297  -44.659 -16.167 1.000 58.628 0 768  HOH A O   1 ? 
HETATM 3539 O O   . HOH F 5 .   ? 9.890   -40.685 -5.837  1.000 37.075 0 769  HOH A O   1 ? 
HETATM 3540 O O   . HOH F 5 .   ? 4.406   -65.948 14.465  1.000 42.634 0 770  HOH A O   1 ? 
HETATM 3541 O O   . HOH F 5 .   ? 16.956  -33.691 12.657  1.000 35.273 0 771  HOH A O   1 ? 
HETATM 3542 O O   . HOH F 5 .   ? 21.835  -53.791 -4.618  1.000 30.759 0 772  HOH A O   1 ? 
HETATM 3543 O O   . HOH F 5 .   ? 18.122  -46.057 -22.408 1.000 37.755 0 773  HOH A O   1 ? 
HETATM 3544 O O   . HOH F 5 .   ? 37.192  -49.232 -7.786  1.000 22.695 0 774  HOH A O   1 ? 
HETATM 3545 O O   . HOH F 5 .   ? 44.152  -24.217 -6.070  1.000 41.163 0 775  HOH A O   1 ? 
HETATM 3546 O O   . HOH F 5 .   ? 10.534  -38.905 22.769  1.000 32.304 0 776  HOH A O   1 ? 
HETATM 3547 O O   . HOH F 5 .   ? 59.324  -48.609 -3.416  1.000 51.638 0 777  HOH A O   1 ? 
HETATM 3548 O O   . HOH F 5 .   ? 31.920  -42.825 1.941   1.000 23.958 0 778  HOH A O   1 ? 
HETATM 3549 O O   . HOH F 5 .   ? -5.864  -46.293 9.425   1.000 43.924 0 779  HOH A O   1 ? 
HETATM 3550 O O   . HOH F 5 .   ? 58.920  -60.636 -7.868  1.000 26.727 0 780  HOH A O   1 ? 
HETATM 3551 O O   . HOH F 5 .   ? 33.360  -21.798 -2.701  1.000 34.515 0 781  HOH A O   1 ? 
HETATM 3552 O O   . HOH F 5 .   ? 11.374  -66.521 11.286  1.000 24.077 0 782  HOH A O   1 ? 
HETATM 3553 O O   . HOH F 5 .   ? 33.703  -22.466 13.480  1.000 30.548 0 783  HOH A O   1 ? 
HETATM 3554 O O   . HOH F 5 .   ? 24.799  -42.954 19.520  0.500 30.738 0 784  HOH A O   1 ? 
HETATM 3555 O O   . HOH F 5 .   ? 35.673  -48.901 -10.143 1.000 26.464 0 785  HOH A O   1 ? 
HETATM 3556 O O   . HOH F 5 .   ? 23.609  -20.871 -10.181 1.000 36.683 0 786  HOH A O   1 ? 
HETATM 3557 O O   . HOH F 5 .   ? 4.809   -44.980 2.724   1.000 25.456 0 787  HOH A O   1 ? 
HETATM 3558 O O   . HOH F 5 .   ? 44.303  -35.130 -11.152 1.000 42.013 0 788  HOH A O   1 ? 
HETATM 3559 O O   . HOH F 5 .   ? 41.974  -26.608 0.627   1.000 34.952 0 789  HOH A O   1 ? 
HETATM 3560 O O   . HOH F 5 .   ? 47.530  -54.880 -12.242 1.000 41.363 0 790  HOH A O   1 ? 
HETATM 3561 O O   . HOH F 5 .   ? 43.049  -32.170 2.526   1.000 31.543 0 791  HOH A O   1 ? 
HETATM 3562 O O   . HOH F 5 .   ? 25.661  -51.657 -3.959  1.000 23.969 0 792  HOH A O   1 ? 
HETATM 3563 O O   . HOH F 5 .   ? 20.116  -51.998 -16.867 1.000 38.910 0 793  HOH A O   1 ? 
HETATM 3564 O O   . HOH F 5 .   ? 45.856  -37.623 12.441  1.000 51.109 0 794  HOH A O   1 ? 
HETATM 3565 O O   . HOH F 5 .   ? 17.069  -52.037 -10.652 1.000 40.163 0 795  HOH A O   1 ? 
HETATM 3566 O O   . HOH F 5 .   ? 14.459  -39.575 0.569   1.000 26.166 0 796  HOH A O   1 ? 
HETATM 3567 O O   . HOH F 5 .   ? 4.758   -29.169 -6.582  1.000 37.647 0 797  HOH A O   1 ? 
HETATM 3568 O O   . HOH F 5 .   ? 48.717  -48.659 -13.318 1.000 43.226 0 798  HOH A O   1 ? 
HETATM 3569 O O   . HOH F 5 .   ? 5.650   -32.354 5.885   1.000 44.226 0 799  HOH A O   1 ? 
HETATM 3570 O O   . HOH F 5 .   ? 43.512  -36.868 5.196   1.000 23.855 0 800  HOH A O   1 ? 
HETATM 3571 O O   . HOH F 5 .   ? 35.619  -60.829 -7.594  1.000 33.830 0 801  HOH A O   1 ? 
HETATM 3572 O O   . HOH F 5 .   ? 11.159  -54.281 -12.700 1.000 49.516 0 802  HOH A O   1 ? 
HETATM 3573 O O   . HOH F 5 .   ? 9.356   -36.065 -1.318  1.000 29.977 0 803  HOH A O   1 ? 
HETATM 3574 O O   . HOH F 5 .   ? 27.902  -34.532 -24.229 1.000 50.135 0 804  HOH A O   1 ? 
HETATM 3575 O O   . HOH F 5 .   ? 36.674  -59.310 -0.946  1.000 24.545 0 805  HOH A O   1 ? 
HETATM 3576 O O   . HOH F 5 .   ? 18.223  -40.073 24.551  1.000 53.485 0 806  HOH A O   1 ? 
HETATM 3577 O O   . HOH F 5 .   ? 15.447  -14.556 12.951  1.000 76.743 0 807  HOH A O   1 ? 
HETATM 3578 O O   . HOH F 5 .   ? 14.617  -37.395 6.691   1.000 38.626 0 808  HOH A O   1 ? 
HETATM 3579 O O   . HOH F 5 .   ? 21.437  -67.638 11.928  1.000 51.627 0 809  HOH A O   1 ? 
HETATM 3580 O O   . HOH F 5 .   ? 44.186  -25.511 -9.533  1.000 38.836 0 810  HOH A O   1 ? 
HETATM 3581 O O   . HOH F 5 .   ? 6.499   -37.331 -13.481 1.000 46.487 0 811  HOH A O   1 ? 
HETATM 3582 O O   . HOH F 5 .   ? 45.360  -31.664 -3.277  1.000 34.704 0 812  HOH A O   1 ? 
HETATM 3583 O O   . HOH F 5 .   ? 47.260  -34.365 -8.153  1.000 64.350 0 813  HOH A O   1 ? 
HETATM 3584 O O   . HOH F 5 .   ? 33.355  -49.468 -8.701  1.000 23.845 0 814  HOH A O   1 ? 
HETATM 3585 O O   . HOH F 5 .   ? 41.971  -36.518 -10.154 1.000 37.689 0 815  HOH A O   1 ? 
HETATM 3586 O O   . HOH F 5 .   ? 23.747  -38.407 0.751   1.000 36.252 0 816  HOH A O   1 ? 
HETATM 3587 O O   . HOH F 5 .   ? 18.897  -25.618 11.755  1.000 35.336 0 817  HOH A O   1 ? 
HETATM 3588 O O   . HOH F 5 .   ? 32.508  -57.977 -7.830  1.000 29.480 0 818  HOH A O   1 ? 
HETATM 3589 O O   . HOH F 5 .   ? 26.448  -55.681 1.443   1.000 18.521 0 819  HOH A O   1 ? 
HETATM 3590 O O   . HOH F 5 .   ? 48.771  -38.153 9.418   1.000 47.179 0 820  HOH A O   1 ? 
HETATM 3591 O O   . HOH F 5 .   ? 13.933  -33.871 13.954  1.000 41.408 0 821  HOH A O   1 ? 
HETATM 3592 O O   . HOH F 5 .   ? 14.424  -32.824 21.664  1.000 58.365 0 822  HOH A O   1 ? 
HETATM 3593 O O   . HOH F 5 .   ? 14.947  -41.824 -11.765 1.000 28.693 0 823  HOH A O   1 ? 
HETATM 3594 O O   . HOH F 5 .   ? 36.336  -51.568 -10.699 1.000 62.379 0 824  HOH A O   1 ? 
HETATM 3595 O O   . HOH F 5 .   ? 24.671  -57.674 21.494  1.000 33.270 0 825  HOH A O   1 ? 
HETATM 3596 O O   . HOH F 5 .   ? 32.430  -21.128 7.161   1.000 46.390 0 826  HOH A O   1 ? 
HETATM 3597 O O   . HOH F 5 .   ? 38.990  -49.420 -12.930 1.000 34.909 0 827  HOH A O   1 ? 
HETATM 3598 O O   . HOH F 5 .   ? 13.553  -47.206 0.188   1.000 22.871 0 828  HOH A O   1 ? 
HETATM 3599 O O   . HOH F 5 .   ? 20.629  -16.953 -5.222  1.000 45.569 0 829  HOH A O   1 ? 
HETATM 3600 O O   . HOH F 5 .   ? 21.951  -13.925 -0.484  1.000 48.098 0 830  HOH A O   1 ? 
HETATM 3601 O O   . HOH F 5 .   ? 11.587  -45.455 -15.337 1.000 58.518 0 831  HOH A O   1 ? 
HETATM 3602 O O   . HOH F 5 .   ? 53.096  -49.250 -3.181  1.000 23.961 0 832  HOH A O   1 ? 
HETATM 3603 O O   . HOH F 5 .   ? 12.472  -41.625 -20.564 1.000 35.404 0 833  HOH A O   1 ? 
HETATM 3604 O O   . HOH F 5 .   ? 19.453  -36.353 -23.880 1.000 53.575 0 834  HOH A O   1 ? 
HETATM 3605 O O   . HOH F 5 .   ? 27.848  -49.959 18.476  1.000 27.761 0 835  HOH A O   1 ? 
HETATM 3606 O O   . HOH F 5 .   ? 41.264  -33.092 7.519   1.000 42.626 0 836  HOH A O   1 ? 
HETATM 3607 O O   . HOH F 5 .   ? 27.001  -38.676 -24.377 1.000 37.257 0 837  HOH A O   1 ? 
HETATM 3608 O O   . HOH F 5 .   ? 25.759  -19.211 -16.658 1.000 46.474 0 838  HOH A O   1 ? 
HETATM 3609 O O   . HOH F 5 .   ? 31.971  -44.471 -9.319  1.000 25.306 0 839  HOH A O   1 ? 
HETATM 3610 O O   . HOH F 5 .   ? 56.162  -41.354 9.113   1.000 55.820 0 840  HOH A O   1 ? 
HETATM 3611 O O   . HOH F 5 .   ? 14.894  -36.268 17.119  1.000 36.333 0 841  HOH A O   1 ? 
HETATM 3612 O O   . HOH F 5 .   ? 30.305  -29.504 11.695  1.000 24.682 0 842  HOH A O   1 ? 
HETATM 3613 O O   . HOH F 5 .   ? 28.479  -41.310 -27.037 1.000 67.677 0 843  HOH A O   1 ? 
HETATM 3614 O O   . HOH F 5 .   ? 46.584  -29.326 -10.020 1.000 57.583 0 844  HOH A O   1 ? 
HETATM 3615 O O   . HOH F 5 .   ? 23.080  -17.720 13.114  1.000 44.337 0 845  HOH A O   1 ? 
HETATM 3616 O O   . HOH F 5 .   ? 3.211   -25.352 4.057   1.000 56.036 0 846  HOH A O   1 ? 
HETATM 3617 O O   . HOH F 5 .   ? 40.454  -31.163 5.802   1.000 30.312 0 847  HOH A O   1 ? 
HETATM 3618 O O   . HOH F 5 .   ? 35.557  -47.229 -15.065 1.000 50.588 0 848  HOH A O   1 ? 
HETATM 3619 O O   . HOH F 5 .   ? -2.259  -54.679 20.472  1.000 46.800 0 849  HOH A O   1 ? 
HETATM 3620 O O   . HOH F 5 .   ? 37.510  -36.727 -12.380 1.000 28.359 0 850  HOH A O   1 ? 
HETATM 3621 O O   . HOH F 5 .   ? 6.554   -34.207 -10.213 1.000 69.687 0 851  HOH A O   1 ? 
HETATM 3622 O O   . HOH F 5 .   ? 29.545  -52.232 17.305  1.000 38.468 0 852  HOH A O   1 ? 
HETATM 3623 O O   . HOH F 5 .   ? 23.465  -15.078 10.455  1.000 46.777 0 853  HOH A O   1 ? 
HETATM 3624 O O   . HOH F 5 .   ? 51.456  -45.836 -2.182  1.000 29.343 0 854  HOH A O   1 ? 
HETATM 3625 O O   . HOH F 5 .   ? 19.239  -67.939 11.820  1.000 36.791 0 855  HOH A O   1 ? 
HETATM 3626 O O   . HOH F 5 .   ? 6.652   -33.420 13.498  1.000 44.658 0 856  HOH A O   1 ? 
HETATM 3627 O O   . HOH F 5 .   ? 47.727  -40.906 1.905   1.000 43.918 0 857  HOH A O   1 ? 
HETATM 3628 O O   . HOH F 5 .   ? 44.387  -35.051 1.871   1.000 32.654 0 858  HOH A O   1 ? 
HETATM 3629 O O   . HOH F 5 .   ? 37.902  -20.576 -6.129  1.000 62.034 0 859  HOH A O   1 ? 
HETATM 3630 O O   . HOH F 5 .   ? 31.178  -14.396 0.742   1.000 67.442 0 860  HOH A O   1 ? 
HETATM 3631 O O   . HOH F 5 .   ? 26.908  -30.797 -24.029 1.000 42.505 0 861  HOH A O   1 ? 
HETATM 3632 O O   . HOH F 5 .   ? 13.183  -46.779 -13.008 1.000 38.257 0 862  HOH A O   1 ? 
HETATM 3633 O O   . HOH F 5 .   ? 26.348  -18.388 15.817  1.000 57.338 0 863  HOH A O   1 ? 
HETATM 3634 O O   . HOH F 5 .   ? 1.718   -31.407 -0.391  1.000 40.176 0 864  HOH A O   1 ? 
HETATM 3635 O O   . HOH F 5 .   ? 27.942  -49.226 -19.014 1.000 43.087 0 865  HOH A O   1 ? 
HETATM 3636 O O   . HOH F 5 .   ? 17.099  -44.630 -25.079 1.000 46.871 0 866  HOH A O   1 ? 
HETATM 3637 O O   . HOH F 5 .   ? 7.142   -62.235 4.069   1.000 41.758 0 867  HOH A O   1 ? 
HETATM 3638 O O   . HOH F 5 .   ? 10.227  -51.066 22.418  1.000 36.370 0 868  HOH A O   1 ? 
HETATM 3639 O O   . HOH F 5 .   ? 56.000  -46.402 4.195   1.000 41.684 0 869  HOH A O   1 ? 
HETATM 3640 O O   . HOH F 5 .   ? 54.261  -64.375 -8.376  1.000 42.647 0 870  HOH A O   1 ? 
HETATM 3641 O O   . HOH F 5 .   ? 57.053  -48.576 3.113   1.000 29.214 0 871  HOH A O   1 ? 
HETATM 3642 O O   . HOH F 5 .   ? 17.623  -42.681 -10.994 1.000 28.843 0 872  HOH A O   1 ? 
HETATM 3643 O O   . HOH F 5 .   ? 11.542  -46.425 -23.611 1.000 46.040 0 873  HOH A O   1 ? 
HETATM 3644 O O   . HOH F 5 .   ? 39.261  -39.133 -17.721 1.000 57.178 0 874  HOH A O   1 ? 
HETATM 3645 O O   . HOH F 5 .   ? -8.795  -57.802 14.816  1.000 73.804 0 875  HOH A O   1 ? 
HETATM 3646 O O   . HOH F 5 .   ? 30.921  -27.492 -22.508 1.000 59.849 0 876  HOH A O   1 ? 
HETATM 3647 O O   . HOH F 5 .   ? 11.322  -58.298 5.303   1.000 23.561 0 877  HOH A O   1 ? 
HETATM 3648 O O   . HOH F 5 .   ? 55.574  -50.514 -10.627 1.000 30.351 0 878  HOH A O   1 ? 
HETATM 3649 O O   . HOH F 5 .   ? 28.609  -54.976 23.289  1.000 49.372 0 879  HOH A O   1 ? 
HETATM 3650 O O   . HOH F 5 .   ? 12.642  -39.043 -21.405 1.000 36.002 0 880  HOH A O   1 ? 
HETATM 3651 O O   . HOH F 5 .   ? 42.380  -20.493 -5.903  1.000 57.839 0 881  HOH A O   1 ? 
HETATM 3652 O O   . HOH F 5 .   ? 10.879  -36.660 0.975   1.000 26.240 0 882  HOH A O   1 ? 
HETATM 3653 O O   . HOH F 5 .   ? -3.519  -53.041 17.932  1.000 45.105 0 883  HOH A O   1 ? 
HETATM 3654 O O   . HOH F 5 .   ? 34.075  -46.184 -8.641  1.000 25.142 0 884  HOH A O   1 ? 
HETATM 3655 O O   . HOH F 5 .   ? -4.610  -38.612 12.979  1.000 54.549 0 885  HOH A O   1 ? 
HETATM 3656 O O   . HOH F 5 .   ? 49.349  -40.518 7.835   1.000 52.741 0 886  HOH A O   1 ? 
HETATM 3657 O O   . HOH F 5 .   ? 2.023   -54.901 24.021  1.000 37.744 0 887  HOH A O   1 ? 
HETATM 3658 O O   . HOH F 5 .   ? 17.264  -27.639 10.806  1.000 32.799 0 888  HOH A O   1 ? 
HETATM 3659 O O   . HOH F 5 .   ? 2.006   -43.258 25.622  1.000 31.896 0 889  HOH A O   1 ? 
HETATM 3660 O O   . HOH F 5 .   ? 21.314  -20.002 -11.302 1.000 36.075 0 890  HOH A O   1 ? 
HETATM 3661 O O   . HOH F 5 .   ? 1.505   -46.932 27.005  1.000 28.932 0 891  HOH A O   1 ? 
HETATM 3662 O O   . HOH F 5 .   ? 62.598  -52.183 -5.107  1.000 42.968 0 892  HOH A O   1 ? 
HETATM 3663 O O   . HOH F 5 .   ? 9.015   -58.344 2.566   1.000 26.924 0 893  HOH A O   1 ? 
HETATM 3664 O O   . HOH F 5 .   ? 37.146  -59.962 -3.461  1.000 20.179 0 894  HOH A O   1 ? 
HETATM 3665 O O   . HOH F 5 .   ? 41.075  -33.096 15.670  1.000 52.083 0 895  HOH A O   1 ? 
HETATM 3666 O O   . HOH F 5 .   ? 48.406  -45.410 -11.145 1.000 55.665 0 896  HOH A O   1 ? 
HETATM 3667 O O   . HOH F 5 .   ? 50.940  -42.945 4.048   1.000 32.393 0 897  HOH A O   1 ? 
HETATM 3668 O O   . HOH F 5 .   ? 13.677  -17.617 1.901   1.000 41.637 0 898  HOH A O   1 ? 
HETATM 3669 O O   . HOH F 5 .   ? 19.437  -43.676 -25.746 1.000 50.803 0 899  HOH A O   1 ? 
HETATM 3670 O O   . HOH F 5 .   ? -12.530 -46.775 6.094   1.000 36.628 0 900  HOH A O   1 ? 
HETATM 3671 O O   . HOH F 5 .   ? 11.846  -45.348 -10.999 1.000 34.849 0 901  HOH A O   1 ? 
HETATM 3672 O O   . HOH F 5 .   ? 41.287  -52.075 -15.491 1.000 64.347 0 902  HOH A O   1 ? 
HETATM 3673 O O   . HOH F 5 .   ? 38.153  -58.972 -11.396 1.000 40.144 0 903  HOH A O   1 ? 
HETATM 3674 O O   . HOH F 5 .   ? 9.967   -19.725 6.835   1.000 63.397 0 904  HOH A O   1 ? 
HETATM 3675 O O   . HOH F 5 .   ? 23.424  -44.183 -25.988 1.000 46.929 0 905  HOH A O   1 ? 
HETATM 3676 O O   . HOH F 5 .   ? 45.647  -56.885 -8.317  1.000 41.984 0 906  HOH A O   1 ? 
HETATM 3677 O O   . HOH F 5 .   ? 59.510  -50.164 -0.422  1.000 43.803 0 907  HOH A O   1 ? 
HETATM 3678 O O   . HOH F 5 .   ? 4.551   -35.322 3.663   1.000 41.618 0 908  HOH A O   1 ? 
HETATM 3679 O O   . HOH F 5 .   ? 34.119  -19.269 -11.046 1.000 62.089 0 909  HOH A O   1 ? 
HETATM 3680 O O   . HOH F 5 .   ? 40.925  -31.570 -14.947 1.000 40.150 0 910  HOH A O   1 ? 
HETATM 3681 O O   . HOH F 5 .   ? 11.366  -42.889 -15.965 1.000 34.738 0 911  HOH A O   1 ? 
HETATM 3682 O O   . HOH F 5 .   ? 34.456  -31.009 -23.232 1.000 55.920 0 912  HOH A O   1 ? 
HETATM 3683 O O   . HOH F 5 .   ? 22.691  -60.067 18.342  1.000 30.290 0 913  HOH A O   1 ? 
HETATM 3684 O O   . HOH F 5 .   ? 6.482   -59.769 5.135   1.000 39.807 0 914  HOH A O   1 ? 
HETATM 3685 O O   . HOH F 5 .   ? 31.778  -48.464 -15.823 1.000 32.404 0 915  HOH A O   1 ? 
HETATM 3686 O O   . HOH F 5 .   ? 23.629  -49.383 -18.261 1.000 36.333 0 916  HOH A O   1 ? 
HETATM 3687 O O   . HOH F 5 .   ? 12.450  -33.159 17.748  1.000 51.925 0 917  HOH A O   1 ? 
HETATM 3688 O O   . HOH F 5 .   ? 45.559  -57.941 -6.094  1.000 35.860 0 918  HOH A O   1 ? 
HETATM 3689 O O   . HOH F 5 .   ? 26.223  -21.158 -7.853  1.000 37.891 0 919  HOH A O   1 ? 
HETATM 3690 O O   . HOH F 5 .   ? 27.548  -21.368 -17.785 1.000 42.089 0 920  HOH A O   1 ? 
HETATM 3691 O O   . HOH F 5 .   ? 34.637  -22.102 6.323   1.000 51.675 0 921  HOH A O   1 ? 
HETATM 3692 O O   . HOH F 5 .   ? 31.243  -56.252 15.481  1.000 54.078 0 922  HOH A O   1 ? 
HETATM 3693 O O   . HOH F 5 .   ? 21.379  -50.453 -7.019  1.000 33.604 0 923  HOH A O   1 ? 
HETATM 3694 O O   . HOH F 5 .   ? 21.900  -21.605 -19.305 1.000 42.439 0 924  HOH A O   1 ? 
HETATM 3695 O O   . HOH F 5 .   ? 41.448  -23.313 -2.602  1.000 55.667 0 925  HOH A O   1 ? 
HETATM 3696 O O   . HOH F 5 .   ? 19.073  -16.621 14.122  1.000 60.786 0 926  HOH A O   1 ? 
HETATM 3697 O O   . HOH F 5 .   ? 41.880  -47.793 -12.661 1.000 26.664 0 927  HOH A O   1 ? 
HETATM 3698 O O   . HOH F 5 .   ? -1.001  -42.142 7.677   1.000 41.231 0 928  HOH A O   1 ? 
HETATM 3699 O O   . HOH F 5 .   ? 2.682   -33.212 2.327   1.000 46.774 0 929  HOH A O   1 ? 
HETATM 3700 O O   . HOH F 5 .   ? -0.978  -34.425 17.817  1.000 48.195 0 930  HOH A O   1 ? 
HETATM 3701 O O   . HOH F 5 .   ? 10.945  -41.077 24.731  1.000 34.796 0 931  HOH A O   1 ? 
HETATM 3702 O O   . HOH F 5 .   ? 3.803   -51.353 27.302  1.000 39.900 0 932  HOH A O   1 ? 
HETATM 3703 O O   . HOH F 5 .   ? 8.205   -42.792 -0.991  1.000 34.899 0 933  HOH A O   1 ? 
HETATM 3704 O O   . HOH F 5 .   ? 3.850   -24.670 -5.067  1.000 57.078 0 934  HOH A O   1 ? 
HETATM 3705 O O   . HOH F 5 .   ? 32.642  -34.213 -23.783 1.000 47.790 0 935  HOH A O   1 ? 
HETATM 3706 O O   . HOH F 5 .   ? 8.090   -61.182 6.376   1.000 28.369 0 936  HOH A O   1 ? 
HETATM 3707 O O   . HOH F 5 .   ? 46.439  -37.231 -8.175  1.000 47.042 0 937  HOH A O   1 ? 
HETATM 3708 O O   . HOH F 5 .   ? 36.073  -36.053 -24.272 1.000 54.278 0 938  HOH A O   1 ? 
HETATM 3709 O O   . HOH F 5 .   ? 39.334  -25.163 6.851   1.000 40.752 0 939  HOH A O   1 ? 
HETATM 3710 O O   . HOH F 5 .   ? -7.567  -46.097 21.368  1.000 41.263 0 940  HOH A O   1 ? 
HETATM 3711 O O   . HOH F 5 .   ? -3.499  -35.932 18.513  1.000 43.318 0 941  HOH A O   1 ? 
HETATM 3712 O O   . HOH F 5 .   ? 18.764  -50.976 -1.980  1.000 29.417 0 942  HOH A O   1 ? 
HETATM 3713 O O   . HOH F 5 .   ? 12.277  -56.630 -13.288 1.000 57.804 0 943  HOH A O   1 ? 
HETATM 3714 O O   . HOH F 5 .   ? -5.461  -42.581 23.672  1.000 49.398 0 944  HOH A O   1 ? 
HETATM 3715 O O   . HOH F 5 .   ? 24.636  -16.362 15.240  1.000 58.673 0 945  HOH A O   1 ? 
HETATM 3716 O O   . HOH F 5 .   ? 20.513  -29.238 12.690  1.000 48.079 0 946  HOH A O   1 ? 
HETATM 3717 O O   . HOH F 5 .   ? 7.375   -31.803 -10.356 1.000 57.120 0 947  HOH A O   1 ? 
HETATM 3718 O O   . HOH F 5 .   ? 26.810  -36.907 12.405  1.000 35.720 0 948  HOH A O   1 ? 
HETATM 3719 O O   . HOH F 5 .   ? 1.107   -53.299 2.219   1.000 35.436 0 949  HOH A O   1 ? 
HETATM 3720 O O   . HOH F 5 .   ? 49.139  -41.975 -0.173  1.000 38.686 0 950  HOH A O   1 ? 
HETATM 3721 O O   . HOH F 5 .   ? 29.425  -54.558 17.139  1.000 50.661 0 951  HOH A O   1 ? 
HETATM 3722 O O   . HOH F 5 .   ? 8.954   -43.908 -20.581 1.000 43.021 0 952  HOH A O   1 ? 
HETATM 3723 O O   . HOH F 5 .   ? 9.233   -45.008 -15.339 1.000 34.607 0 953  HOH A O   1 ? 
HETATM 3724 O O   . HOH F 5 .   ? 25.963  -39.455 13.222  1.000 45.100 0 954  HOH A O   1 ? 
HETATM 3725 O O   . HOH F 5 .   ? 49.766  -41.471 13.223  1.000 53.254 0 955  HOH A O   1 ? 
HETATM 3726 O O   . HOH F 5 .   ? 14.665  -27.171 11.858  1.000 41.758 0 956  HOH A O   1 ? 
HETATM 3727 O O   . HOH F 5 .   ? 30.012  -15.546 -2.196  1.000 65.671 0 957  HOH A O   1 ? 
HETATM 3728 O O   . HOH F 5 .   ? 37.246  -42.781 -23.722 1.000 69.111 0 958  HOH A O   1 ? 
HETATM 3729 O O   . HOH F 5 .   ? 22.744  -25.328 -22.967 1.000 62.723 0 959  HOH A O   1 ? 
HETATM 3730 O O   . HOH F 5 .   ? 0.009   -55.615 21.026  1.000 60.062 0 960  HOH A O   1 ? 
HETATM 3731 O O   . HOH F 5 .   ? 12.802  -62.853 20.211  1.000 46.858 0 961  HOH A O   1 ? 
HETATM 3732 O O   . HOH F 5 .   ? 33.379  -53.532 -9.964  1.000 34.794 0 962  HOH A O   1 ? 
HETATM 3733 O O   . HOH F 5 .   ? -6.268  -52.394 17.208  1.000 50.938 0 963  HOH A O   1 ? 
HETATM 3734 O O   . HOH F 5 .   ? 11.764  -48.389 -14.711 1.000 59.768 0 964  HOH A O   1 ? 
HETATM 3735 O O   . HOH F 5 .   ? 11.831  -26.252 -16.179 1.000 60.020 0 965  HOH A O   1 ? 
HETATM 3736 O O   . HOH F 5 .   ? 22.689  -36.308 -23.706 1.000 64.808 0 966  HOH A O   1 ? 
HETATM 3737 O O   . HOH F 5 .   ? -6.301  -46.202 5.696   1.000 58.007 0 967  HOH A O   1 ? 
HETATM 3738 O O   . HOH F 5 .   ? 1.052   -32.027 -2.588  1.000 53.985 0 968  HOH A O   1 ? 
HETATM 3739 O O   . HOH F 5 .   ? 4.546   -38.948 0.017   1.000 42.413 0 969  HOH A O   1 ? 
HETATM 3740 O O   . HOH F 5 .   ? 24.828  -12.523 3.436   1.000 64.608 0 970  HOH A O   1 ? 
HETATM 3741 O O   . HOH F 5 .   ? -8.218  -48.264 9.065   1.000 45.284 0 971  HOH A O   1 ? 
HETATM 3742 O O   . HOH F 5 .   ? 2.646   -25.252 -1.346  1.000 49.672 0 972  HOH A O   1 ? 
HETATM 3743 O O   . HOH F 5 .   ? 13.172  -65.214 16.745  1.000 50.840 0 973  HOH A O   1 ? 
HETATM 3744 O O   . HOH F 5 .   ? 23.316  -40.384 19.520  0.500 45.858 0 974  HOH A O   1 ? 
HETATM 3745 O O   . HOH F 5 .   ? 20.038  -73.286 14.229  1.000 37.365 0 975  HOH A O   1 ? 
HETATM 3746 O O   . HOH F 5 .   ? 38.235  -60.152 -8.442  1.000 43.213 0 976  HOH A O   1 ? 
HETATM 3747 O O   . HOH F 5 .   ? 31.121  -20.546 -1.791  1.000 43.229 0 977  HOH A O   1 ? 
HETATM 3748 O O   . HOH F 5 .   ? 45.360  -54.843 -10.764 1.000 46.124 0 978  HOH A O   1 ? 
HETATM 3749 O O   . HOH F 5 .   ? 1.833   -62.975 8.595   1.000 51.735 0 979  HOH A O   1 ? 
HETATM 3750 O O   . HOH F 5 .   ? 41.220  -27.150 -16.014 1.000 50.985 0 980  HOH A O   1 ? 
HETATM 3751 O O   . HOH F 5 .   ? 51.113  -64.436 -6.577  1.000 34.459 0 981  HOH A O   1 ? 
HETATM 3752 O O   . HOH F 5 .   ? -7.992  -51.265 9.622   1.000 32.736 0 982  HOH A O   1 ? 
HETATM 3753 O O   . HOH F 5 .   ? -6.266  -37.885 8.697   1.000 58.304 0 983  HOH A O   1 ? 
HETATM 3754 O O   . HOH F 5 .   ? 46.827  -34.907 10.565  1.000 69.464 0 984  HOH A O   1 ? 
HETATM 3755 O O   . HOH F 5 .   ? 41.464  -50.524 -12.837 1.000 41.937 0 985  HOH A O   1 ? 
HETATM 3756 O O   . HOH F 5 .   ? 0.540   -64.395 12.642  1.000 54.501 0 986  HOH A O   1 ? 
HETATM 3757 O O   . HOH F 5 .   ? 33.929  -61.867 -9.533  1.000 29.714 0 987  HOH A O   1 ? 
HETATM 3758 O O   . HOH F 5 .   ? 12.583  -47.798 -25.893 1.000 66.826 0 988  HOH A O   1 ? 
HETATM 3759 O O   . HOH F 5 .   ? 13.327  -39.851 -25.942 1.000 64.487 0 989  HOH A O   1 ? 
HETATM 3760 O O   . HOH F 5 .   ? 33.690  -55.968 11.179  1.000 33.994 0 990  HOH A O   1 ? 
HETATM 3761 O O   . HOH F 5 .   ? 20.636  -52.014 -19.604 1.000 43.892 0 991  HOH A O   1 ? 
HETATM 3762 O O   . HOH F 5 .   ? -9.534  -47.646 11.137  1.000 54.743 0 992  HOH A O   1 ? 
HETATM 3763 O O   . HOH F 5 .   ? -1.914  -39.047 9.446   1.000 64.697 0 993  HOH A O   1 ? 
HETATM 3764 O O   . HOH F 5 .   ? 3.049   -33.300 -4.685  1.000 48.193 0 994  HOH A O   1 ? 
HETATM 3765 O O   . HOH F 5 .   ? 11.716  -38.976 -0.297  1.000 26.322 0 995  HOH A O   1 ? 
HETATM 3766 O O   . HOH F 5 .   ? 28.254  -15.603 3.359   1.000 46.777 0 996  HOH A O   1 ? 
HETATM 3767 O O   . HOH F 5 .   ? 35.047  -55.636 13.459  1.000 39.344 0 997  HOH A O   1 ? 
HETATM 3768 O O   . HOH F 5 .   ? 6.196   -29.436 -9.106  1.000 51.356 0 998  HOH A O   1 ? 
HETATM 3769 O O   . HOH F 5 .   ? -1.521  -51.756 24.609  1.000 43.608 0 999  HOH A O   1 ? 
HETATM 3770 O O   . HOH F 5 .   ? 48.608  -39.412 3.943   1.000 41.234 0 1000 HOH A O   1 ? 
HETATM 3771 O O   . HOH F 5 .   ? -9.675  -46.369 13.609  1.000 42.402 0 1001 HOH A O   1 ? 
HETATM 3772 O O   . HOH F 5 .   ? 39.076  -22.777 -2.934  1.000 53.496 0 1002 HOH A O   1 ? 
HETATM 3773 O O   . HOH F 5 .   ? 30.819  -55.136 5.074   1.000 23.908 0 1003 HOH A O   1 ? 
HETATM 3774 O O   . HOH F 5 .   ? 3.956   -26.588 -6.942  1.000 53.041 0 1004 HOH A O   1 ? 
HETATM 3775 O O   . HOH F 5 .   ? 63.286  -55.066 -2.213  1.000 37.499 0 1005 HOH A O   1 ? 
HETATM 3776 O O   . HOH F 5 .   ? 47.165  -30.398 -5.044  1.000 49.893 0 1006 HOH A O   1 ? 
HETATM 3777 O O   . HOH F 5 .   ? 40.667  -27.605 6.985   1.000 37.541 0 1007 HOH A O   1 ? 
HETATM 3778 O O   . HOH F 5 .   ? 24.730  -59.644 20.490  1.000 39.160 0 1008 HOH A O   1 ? 
HETATM 3779 O O   . HOH F 5 .   ? 44.509  -30.302 1.097   1.000 40.808 0 1009 HOH A O   1 ? 
HETATM 3780 O O   . HOH F 5 .   ? -0.343  -44.217 26.987  1.000 58.904 0 1010 HOH A O   1 ? 
HETATM 3781 O O   . HOH F 5 .   ? 7.476   -24.941 6.843   1.000 68.203 0 1011 HOH A O   1 ? 
HETATM 3782 O O   . HOH F 5 .   ? 44.831  -34.523 5.858   1.000 37.699 0 1012 HOH A O   1 ? 
HETATM 3783 O O   . HOH F 5 .   ? 25.695  -51.175 -18.068 1.000 67.745 0 1013 HOH A O   1 ? 
HETATM 3784 O O   . HOH F 5 .   ? 5.298   -21.277 -4.075  1.000 72.743 0 1014 HOH A O   1 ? 
HETATM 3785 O O   . HOH F 5 .   ? 47.337  -35.024 7.056   1.000 55.107 0 1015 HOH A O   1 ? 
HETATM 3786 O O   . HOH F 5 .   ? 39.615  -27.609 -17.821 1.000 55.228 0 1016 HOH A O   1 ? 
HETATM 3787 O O   . HOH F 5 .   ? 33.347  -53.905 5.104   1.000 22.808 0 1017 HOH A O   1 ? 
HETATM 3788 O O   . HOH F 5 .   ? 34.518  -20.005 -4.380  1.000 48.111 0 1018 HOH A O   1 ? 
HETATM 3789 O O   . HOH F 5 .   ? 52.597  -64.516 -10.585 1.000 44.792 0 1019 HOH A O   1 ? 
HETATM 3790 O O   . HOH F 5 .   ? 16.859  -17.448 14.961  1.000 73.298 0 1020 HOH A O   1 ? 
HETATM 3791 O O   . HOH F 5 .   ? 29.716  -55.807 9.558   1.000 42.771 0 1021 HOH A O   1 ? 
HETATM 3792 O O   . HOH F 5 .   ? 0.128   -39.874 26.821  1.000 38.860 0 1022 HOH A O   1 ? 
HETATM 3793 O O   . HOH F 5 .   ? 12.750  -42.052 -13.479 1.000 37.141 0 1023 HOH A O   1 ? 
HETATM 3794 O O   . HOH F 5 .   ? 30.219  -18.338 -3.324  1.000 50.722 0 1024 HOH A O   1 ? 
HETATM 3795 O O   . HOH F 5 .   ? 10.925  -41.681 -18.265 1.000 37.433 0 1025 HOH A O   1 ? 
HETATM 3796 O O   . HOH F 5 .   ? 9.690   -22.166 5.359   1.000 51.132 0 1026 HOH A O   1 ? 
HETATM 3797 O O   . HOH F 5 .   ? -2.587  -58.826 16.609  1.000 42.447 0 1027 HOH A O   1 ? 
HETATM 3798 O O   . HOH F 5 .   ? 34.759  -21.307 -0.608  1.000 61.136 0 1028 HOH A O   1 ? 
HETATM 3799 O O   . HOH F 5 .   ? 0.680   -48.652 29.307  1.000 54.664 0 1029 HOH A O   1 ? 
HETATM 3800 O O   . HOH F 5 .   ? 3.796   -22.219 -5.980  1.000 71.338 0 1030 HOH A O   1 ? 
HETATM 3801 O O   . HOH F 5 .   ? 7.447   -36.316 -10.061 1.000 66.153 0 1031 HOH A O   1 ? 
HETATM 3802 O O   . HOH F 5 .   ? 49.210  -36.442 7.377   1.000 64.189 0 1032 HOH A O   1 ? 
HETATM 3803 O O   . HOH F 5 .   ? 9.861   -64.560 22.166  1.000 62.505 0 1033 HOH A O   1 ? 
HETATM 3804 O O   . HOH F 5 .   ? -5.295  -50.858 6.058   1.000 32.025 0 1034 HOH A O   1 ? 
HETATM 3805 O O   . HOH F 5 .   ? 17.412  -51.534 -4.309  1.000 33.846 0 1035 HOH A O   1 ? 
HETATM 3806 O O   . HOH F 5 .   ? 54.970  -52.316 -12.951 1.000 47.490 0 1036 HOH A O   1 ? 
HETATM 3807 O O   . HOH F 5 .   ? 42.344  -32.301 -17.163 1.000 61.202 0 1037 HOH A O   1 ? 
HETATM 3808 O O   . HOH F 5 .   ? 46.331  -35.656 -4.970  1.000 53.575 0 1038 HOH A O   1 ? 
HETATM 3809 O O   . HOH F 5 .   ? 14.933  -33.265 24.213  1.000 61.110 0 1039 HOH A O   1 ? 
HETATM 3810 O O   . HOH F 5 .   ? 24.856  -18.558 -8.862  1.000 52.646 0 1040 HOH A O   1 ? 
HETATM 3811 O O   . HOH F 5 .   ? 5.145   -24.927 -3.043  1.000 47.900 0 1041 HOH A O   1 ? 
HETATM 3812 O O   . HOH F 5 .   ? 23.749  -19.635 -18.481 1.000 49.364 0 1042 HOH A O   1 ? 
HETATM 3813 O O   . HOH F 5 .   ? 3.344   -36.246 -3.702  1.000 52.046 0 1043 HOH A O   1 ? 
HETATM 3814 O O   . HOH F 5 .   ? 59.567  -48.461 1.620   1.000 49.356 0 1044 HOH A O   1 ? 
HETATM 3815 O O   . HOH F 5 .   ? -7.710  -47.665 25.307  1.000 65.974 0 1045 HOH A O   1 ? 
HETATM 3816 O O   . HOH F 5 .   ? 23.610  -52.268 -5.763  1.000 33.372 0 1046 HOH A O   1 ? 
HETATM 3817 O O   . HOH F 5 .   ? -3.146  -44.828 26.848  1.000 62.768 0 1047 HOH A O   1 ? 
HETATM 3818 O O   . HOH F 5 .   ? 10.142  -23.853 7.896   1.000 42.123 0 1048 HOH A O   1 ? 
HETATM 3819 O O   . HOH F 5 .   ? 6.239   -27.001 -9.221  1.000 59.778 0 1049 HOH A O   1 ? 
HETATM 3820 O O   . HOH F 5 .   ? 43.653  -33.525 7.894   1.000 48.727 0 1050 HOH A O   1 ? 
HETATM 3821 O O   . HOH F 5 .   ? 40.266  -39.254 -14.917 1.000 58.204 0 1051 HOH A O   1 ? 
HETATM 3822 O O   . HOH F 5 .   ? 5.896   -31.309 14.117  1.000 55.765 0 1052 HOH A O   1 ? 
HETATM 3823 O O   . HOH F 5 .   ? -0.028  -59.699 20.167  1.000 49.719 0 1053 HOH A O   1 ? 
HETATM 3824 O O   . HOH F 5 .   ? 25.079  -51.605 -14.989 1.000 65.389 0 1054 HOH A O   1 ? 
HETATM 3825 O O   . HOH F 5 .   ? 48.174  -51.112 -13.719 1.000 45.155 0 1055 HOH A O   1 ? 
HETATM 3826 O O   . HOH F 5 .   ? 59.801  -52.588 2.054   1.000 59.339 0 1056 HOH A O   1 ? 
HETATM 3827 O O   . HOH F 5 .   ? -8.991  -40.374 22.944  1.000 57.423 0 1057 HOH A O   1 ? 
HETATM 3828 O O   . HOH F 5 .   ? 21.642  -17.439 -11.675 1.000 54.301 0 1058 HOH A O   1 ? 
HETATM 3829 O O   . HOH F 5 .   ? 18.309  -30.012 11.894  1.000 36.607 0 1059 HOH A O   1 ? 
HETATM 3830 O O   . HOH F 5 .   ? 12.794  -68.674 11.766  1.000 47.914 0 1060 HOH A O   1 ? 
HETATM 3831 O O   . HOH F 5 .   ? 4.721   -58.719 2.760   1.000 59.712 0 1061 HOH A O   1 ? 
HETATM 3832 O O   . HOH F 5 .   ? 19.405  -52.500 -5.830  1.000 37.075 0 1062 HOH A O   1 ? 
HETATM 3833 O O   . HOH F 5 .   ? -5.746  -47.634 26.475  1.000 61.268 0 1063 HOH A O   1 ? 
HETATM 3834 O O   . HOH F 5 .   ? 27.595  -36.780 -26.490 1.000 62.829 0 1064 HOH A O   1 ? 
HETATM 3835 O O   . HOH F 5 .   ? 40.836  -33.881 -13.701 1.000 35.854 0 1065 HOH A O   1 ? 
HETATM 3836 O O   . HOH F 5 .   ? -6.166  -44.874 23.469  1.000 43.605 0 1066 HOH A O   1 ? 
HETATM 3837 O O   . HOH F 5 .   ? 3.486   -57.353 24.230  1.000 54.886 0 1067 HOH A O   1 ? 
HETATM 3838 O O   . HOH F 5 .   ? 63.781  -57.615 1.232   1.000 33.554 0 1068 HOH A O   1 ? 
HETATM 3839 O O   . HOH F 5 .   ? 46.385  -36.976 -11.120 1.000 77.180 0 1069 HOH A O   1 ? 
HETATM 3840 O O   . HOH F 5 .   ? 22.271  -49.841 -20.656 1.000 52.651 0 1070 HOH A O   1 ? 
HETATM 3841 O O   . HOH F 5 .   ? 22.142  -13.083 3.453   1.000 60.320 0 1071 HOH A O   1 ? 
HETATM 3842 O O   . HOH F 5 .   ? 30.170  -56.792 7.307   1.000 45.384 0 1072 HOH A O   1 ? 
HETATM 3843 O O   . HOH F 5 .   ? 45.061  -33.769 9.879   1.000 49.911 0 1073 HOH A O   1 ? 
HETATM 3844 O O   . HOH F 5 .   ? 3.455   -31.487 -6.688  1.000 60.899 0 1074 HOH A O   1 ? 
HETATM 3845 O O   . HOH F 5 .   ? 43.637  -34.064 -13.351 1.000 42.358 0 1075 HOH A O   1 ? 
HETATM 3846 O O   . HOH F 5 .   ? 0.229   -39.422 8.092   1.000 64.339 0 1076 HOH A O   1 ? 
HETATM 3847 O O   . HOH F 5 .   ? 46.238  -31.315 -0.745  1.000 48.787 0 1077 HOH A O   1 ? 
HETATM 3848 O O   . HOH F 5 .   ? 2.660   -61.490 22.222  1.000 63.563 0 1078 HOH A O   1 ? 
HETATM 3849 O O   . HOH F 5 .   ? 11.471  -67.008 14.244  1.000 42.774 0 1079 HOH A O   1 ? 
HETATM 3850 O O   . HOH F 5 .   ? 6.726   -22.752 -2.256  1.000 71.619 0 1080 HOH A O   1 ? 
HETATM 3851 O O   . HOH F 5 .   ? 18.240  -68.446 19.114  1.000 44.392 0 1081 HOH A O   1 ? 
HETATM 3852 O O   . HOH F 5 .   ? 44.652  -33.183 3.817   1.000 48.643 0 1082 HOH A O   1 ? 
HETATM 3853 O O   . HOH F 5 .   ? 38.129  -22.079 9.136   1.000 42.745 0 1083 HOH A O   1 ? 
HETATM 3854 O O   . HOH F 5 .   ? 41.970  -29.039 -14.043 1.000 43.016 0 1084 HOH A O   1 ? 
HETATM 3855 O O   . HOH F 5 .   ? 36.048  -28.768 -20.238 1.000 46.511 0 1085 HOH A O   1 ? 
HETATM 3856 O O   . HOH F 5 .   ? 21.346  -19.195 15.122  1.000 61.428 0 1086 HOH A O   1 ? 
HETATM 3857 O O   . HOH F 5 .   ? 3.121   -50.657 30.005  1.000 62.028 0 1087 HOH A O   1 ? 
HETATM 3858 O O   . HOH F 5 .   ? 10.866  -42.948 -22.091 1.000 42.666 0 1088 HOH A O   1 ? 
HETATM 3859 O O   . HOH F 5 .   ? -1.070  -41.623 28.449  1.000 57.365 0 1089 HOH A O   1 ? 
HETATM 3860 O O   . HOH F 5 .   ? 17.158  -24.370 13.331  1.000 41.360 0 1090 HOH A O   1 ? 
HETATM 3861 O O   . HOH F 5 .   ? 49.827  -45.274 14.976  1.000 37.815 0 1091 HOH A O   1 ? 
HETATM 3862 O O   . HOH F 5 .   ? 39.051  -48.586 -15.548 1.000 61.900 0 1092 HOH A O   1 ? 
HETATM 3863 O O   . HOH F 5 .   ? 42.396  -29.438 4.863   1.000 58.752 0 1093 HOH A O   1 ? 
HETATM 3864 O O   . HOH F 5 .   ? 12.816  -38.094 -23.948 1.000 48.390 0 1094 HOH A O   1 ? 
HETATM 3865 O O   . HOH F 5 .   ? 53.671  -41.810 5.101   1.000 50.093 0 1095 HOH A O   1 ? 
HETATM 3866 O O   . HOH F 5 .   ? 41.129  -42.105 -13.971 1.000 51.935 0 1096 HOH A O   1 ? 
HETATM 3867 O O   . HOH F 5 .   ? 42.473  -27.364 3.850   1.000 67.642 0 1097 HOH A O   1 ? 
HETATM 3868 O O   . HOH F 5 .   ? 17.820  -64.031 18.574  1.000 25.708 0 1098 HOH A O   1 ? 
HETATM 3869 O O   . HOH F 5 .   ? 44.041  -47.464 -14.242 1.000 51.577 0 1099 HOH A O   1 ? 
HETATM 3870 O O   . HOH F 5 .   ? 65.410  -55.873 0.000   0.500 47.456 0 1100 HOH A O   1 ? 
HETATM 3871 O O   . HOH F 5 .   ? 39.970  -35.745 -11.775 1.000 38.978 0 1101 HOH A O   1 ? 
HETATM 3872 O O   . HOH F 5 .   ? 41.922  -46.218 -15.524 1.000 57.325 0 1102 HOH A O   1 ? 
HETATM 3873 O O   . HOH F 5 .   ? 15.640  -65.806 17.411  1.000 39.647 0 1103 HOH A O   1 ? 
HETATM 3874 O O   . HOH F 5 .   ? 41.839  -44.012 -15.280 1.000 57.528 0 1104 HOH A O   1 ? 
HETATM 3875 O O   . HOH F 5 .   ? 41.641  -37.696 -13.336 1.000 55.570 0 1105 HOH A O   1 ? 
HETATM 3876 O O   . HOH F 5 .   ? 40.728  -21.312 8.668   1.000 65.974 0 1106 HOH A O   1 ? 
HETATM 3877 O O   . HOH F 5 .   ? 47.161  -31.951 3.407   1.000 61.778 0 1107 HOH A O   1 ? 
HETATM 3878 O O   . HOH F 5 .   ? 17.395  -22.512 15.482  1.000 45.382 0 1108 HOH A O   1 ? 
# 
