data_8WYW
# 
_entry.id   8WYW 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8WYW         pdb_00008wyw 10.2210/pdb8wyw/pdb 
WWPDB D_1300042262 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-06 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8WYW 
_pdbx_database_status.recvd_initial_deposition_date   2023-10-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              bilee@ncc.re.kr 
_pdbx_contact_author.name_first         'Byung Il' 
_pdbx_contact_author.name_last          Lee 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1270-8439 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bong, S.M.' 1 ? 
'Lee, B.I.'  2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Crystal structure of spleen tyrosine kinase (Syk) in complex with SKI-O-592 (free form of SKI-O-703, cevidoplenib)' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Bong, S.M.' 1 0000-0001-8288-1283 
primary 'Lee, B.I.'  2 0000-0003-1270-8439 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Tyrosine-protein kinase SYK' 34216.398 2   2.7.10.2 ? 'UNP residues 356-635' ? 
2 non-polymer syn SKI-O-592                     473.527   2   ?        ? ?                      ? 
3 non-polymer syn GLYCEROL                      92.094    1   ?        ? ?                      ? 
4 water       nat water                         18.015    107 ?        ? ?                      ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Spleen tyrosine kinase,p72-Syk' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MALEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI
VRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISD
FGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG
CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNLEHHHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MALEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI
VRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISD
FGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG
CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNLEHHHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 SKI-O-592 XFB 
3 GLYCEROL  GOL 
4 water     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   LEU n 
1 4   GLU n 
1 5   GLU n 
1 6   ILE n 
1 7   ARG n 
1 8   PRO n 
1 9   LYS n 
1 10  GLU n 
1 11  VAL n 
1 12  TYR n 
1 13  LEU n 
1 14  ASP n 
1 15  ARG n 
1 16  LYS n 
1 17  LEU n 
1 18  LEU n 
1 19  THR n 
1 20  LEU n 
1 21  GLU n 
1 22  ASP n 
1 23  LYS n 
1 24  GLU n 
1 25  LEU n 
1 26  GLY n 
1 27  SER n 
1 28  GLY n 
1 29  ASN n 
1 30  PHE n 
1 31  GLY n 
1 32  THR n 
1 33  VAL n 
1 34  LYS n 
1 35  LYS n 
1 36  GLY n 
1 37  TYR n 
1 38  TYR n 
1 39  GLN n 
1 40  MET n 
1 41  LYS n 
1 42  LYS n 
1 43  VAL n 
1 44  VAL n 
1 45  LYS n 
1 46  THR n 
1 47  VAL n 
1 48  ALA n 
1 49  VAL n 
1 50  LYS n 
1 51  ILE n 
1 52  LEU n 
1 53  LYS n 
1 54  ASN n 
1 55  GLU n 
1 56  ALA n 
1 57  ASN n 
1 58  ASP n 
1 59  PRO n 
1 60  ALA n 
1 61  LEU n 
1 62  LYS n 
1 63  ASP n 
1 64  GLU n 
1 65  LEU n 
1 66  LEU n 
1 67  ALA n 
1 68  GLU n 
1 69  ALA n 
1 70  ASN n 
1 71  VAL n 
1 72  MET n 
1 73  GLN n 
1 74  GLN n 
1 75  LEU n 
1 76  ASP n 
1 77  ASN n 
1 78  PRO n 
1 79  TYR n 
1 80  ILE n 
1 81  VAL n 
1 82  ARG n 
1 83  MET n 
1 84  ILE n 
1 85  GLY n 
1 86  ILE n 
1 87  CYS n 
1 88  GLU n 
1 89  ALA n 
1 90  GLU n 
1 91  SER n 
1 92  TRP n 
1 93  MET n 
1 94  LEU n 
1 95  VAL n 
1 96  MET n 
1 97  GLU n 
1 98  MET n 
1 99  ALA n 
1 100 GLU n 
1 101 LEU n 
1 102 GLY n 
1 103 PRO n 
1 104 LEU n 
1 105 ASN n 
1 106 LYS n 
1 107 TYR n 
1 108 LEU n 
1 109 GLN n 
1 110 GLN n 
1 111 ASN n 
1 112 ARG n 
1 113 HIS n 
1 114 VAL n 
1 115 LYS n 
1 116 ASP n 
1 117 LYS n 
1 118 ASN n 
1 119 ILE n 
1 120 ILE n 
1 121 GLU n 
1 122 LEU n 
1 123 VAL n 
1 124 HIS n 
1 125 GLN n 
1 126 VAL n 
1 127 SER n 
1 128 MET n 
1 129 GLY n 
1 130 MET n 
1 131 LYS n 
1 132 TYR n 
1 133 LEU n 
1 134 GLU n 
1 135 GLU n 
1 136 SER n 
1 137 ASN n 
1 138 PHE n 
1 139 VAL n 
1 140 HIS n 
1 141 ARG n 
1 142 ASP n 
1 143 LEU n 
1 144 ALA n 
1 145 ALA n 
1 146 ARG n 
1 147 ASN n 
1 148 VAL n 
1 149 LEU n 
1 150 LEU n 
1 151 VAL n 
1 152 THR n 
1 153 GLN n 
1 154 HIS n 
1 155 TYR n 
1 156 ALA n 
1 157 LYS n 
1 158 ILE n 
1 159 SER n 
1 160 ASP n 
1 161 PHE n 
1 162 GLY n 
1 163 LEU n 
1 164 SER n 
1 165 LYS n 
1 166 ALA n 
1 167 LEU n 
1 168 ARG n 
1 169 ALA n 
1 170 ASP n 
1 171 GLU n 
1 172 ASN n 
1 173 TYR n 
1 174 TYR n 
1 175 LYS n 
1 176 ALA n 
1 177 GLN n 
1 178 THR n 
1 179 HIS n 
1 180 GLY n 
1 181 LYS n 
1 182 TRP n 
1 183 PRO n 
1 184 VAL n 
1 185 LYS n 
1 186 TRP n 
1 187 TYR n 
1 188 ALA n 
1 189 PRO n 
1 190 GLU n 
1 191 CYS n 
1 192 ILE n 
1 193 ASN n 
1 194 TYR n 
1 195 TYR n 
1 196 LYS n 
1 197 PHE n 
1 198 SER n 
1 199 SER n 
1 200 LYS n 
1 201 SER n 
1 202 ASP n 
1 203 VAL n 
1 204 TRP n 
1 205 SER n 
1 206 PHE n 
1 207 GLY n 
1 208 VAL n 
1 209 LEU n 
1 210 MET n 
1 211 TRP n 
1 212 GLU n 
1 213 ALA n 
1 214 PHE n 
1 215 SER n 
1 216 TYR n 
1 217 GLY n 
1 218 GLN n 
1 219 LYS n 
1 220 PRO n 
1 221 TYR n 
1 222 ARG n 
1 223 GLY n 
1 224 MET n 
1 225 LYS n 
1 226 GLY n 
1 227 SER n 
1 228 GLU n 
1 229 VAL n 
1 230 THR n 
1 231 ALA n 
1 232 MET n 
1 233 LEU n 
1 234 GLU n 
1 235 LYS n 
1 236 GLY n 
1 237 GLU n 
1 238 ARG n 
1 239 MET n 
1 240 GLY n 
1 241 CYS n 
1 242 PRO n 
1 243 ALA n 
1 244 GLY n 
1 245 CYS n 
1 246 PRO n 
1 247 ARG n 
1 248 GLU n 
1 249 MET n 
1 250 TYR n 
1 251 ASP n 
1 252 LEU n 
1 253 MET n 
1 254 ASN n 
1 255 LEU n 
1 256 CYS n 
1 257 TRP n 
1 258 THR n 
1 259 TYR n 
1 260 ASP n 
1 261 VAL n 
1 262 GLU n 
1 263 ASN n 
1 264 ARG n 
1 265 PRO n 
1 266 GLY n 
1 267 PHE n 
1 268 ALA n 
1 269 ALA n 
1 270 VAL n 
1 271 GLU n 
1 272 LEU n 
1 273 ARG n 
1 274 LEU n 
1 275 ARG n 
1 276 ASN n 
1 277 TYR n 
1 278 TYR n 
1 279 TYR n 
1 280 ASP n 
1 281 VAL n 
1 282 VAL n 
1 283 ASN n 
1 284 LEU n 
1 285 GLU n 
1 286 HIS n 
1 287 HIS n 
1 288 HIS n 
1 289 HIS n 
1 290 HIS n 
1 291 HIS n 
1 292 HIS n 
1 293 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   293 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 SYK 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
XFB non-polymer         . SKI-O-592       
;cyclopropyl-[1-methyl-5-[[4-[3-methyl-4-[[(4S)-4-oxidanyl-1,2-oxazolidin-2-yl]methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]indol-3-yl]methanone
;
'C25 H27 N7 O3'  473.527 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   353 ?   ?   ?   A . n 
A 1 2   ALA 2   354 ?   ?   ?   A . n 
A 1 3   LEU 3   355 ?   ?   ?   A . n 
A 1 4   GLU 4   356 ?   ?   ?   A . n 
A 1 5   GLU 5   357 ?   ?   ?   A . n 
A 1 6   ILE 6   358 ?   ?   ?   A . n 
A 1 7   ARG 7   359 ?   ?   ?   A . n 
A 1 8   PRO 8   360 ?   ?   ?   A . n 
A 1 9   LYS 9   361 ?   ?   ?   A . n 
A 1 10  GLU 10  362 ?   ?   ?   A . n 
A 1 11  VAL 11  363 ?   ?   ?   A . n 
A 1 12  TYR 12  364 364 TYR TYR A . n 
A 1 13  LEU 13  365 365 LEU LEU A . n 
A 1 14  ASP 14  366 366 ASP ASP A . n 
A 1 15  ARG 15  367 367 ARG ARG A . n 
A 1 16  LYS 16  368 368 LYS LYS A . n 
A 1 17  LEU 17  369 369 LEU LEU A . n 
A 1 18  LEU 18  370 370 LEU LEU A . n 
A 1 19  THR 19  371 371 THR THR A . n 
A 1 20  LEU 20  372 372 LEU LEU A . n 
A 1 21  GLU 21  373 373 GLU GLU A . n 
A 1 22  ASP 22  374 374 ASP ASP A . n 
A 1 23  LYS 23  375 375 LYS LYS A . n 
A 1 24  GLU 24  376 376 GLU GLU A . n 
A 1 25  LEU 25  377 377 LEU LEU A . n 
A 1 26  GLY 26  378 378 GLY GLY A . n 
A 1 27  SER 27  379 379 SER SER A . n 
A 1 28  GLY 28  380 380 GLY GLY A . n 
A 1 29  ASN 29  381 381 ASN ASN A . n 
A 1 30  PHE 30  382 382 PHE PHE A . n 
A 1 31  GLY 31  383 383 GLY GLY A . n 
A 1 32  THR 32  384 384 THR THR A . n 
A 1 33  VAL 33  385 385 VAL VAL A . n 
A 1 34  LYS 34  386 386 LYS LYS A . n 
A 1 35  LYS 35  387 387 LYS LYS A . n 
A 1 36  GLY 36  388 388 GLY GLY A . n 
A 1 37  TYR 37  389 389 TYR TYR A . n 
A 1 38  TYR 38  390 390 TYR TYR A . n 
A 1 39  GLN 39  391 391 GLN GLN A . n 
A 1 40  MET 40  392 392 MET MET A . n 
A 1 41  LYS 41  393 393 LYS LYS A . n 
A 1 42  LYS 42  394 394 LYS LYS A . n 
A 1 43  VAL 43  395 395 VAL VAL A . n 
A 1 44  VAL 44  396 396 VAL VAL A . n 
A 1 45  LYS 45  397 397 LYS LYS A . n 
A 1 46  THR 46  398 398 THR THR A . n 
A 1 47  VAL 47  399 399 VAL VAL A . n 
A 1 48  ALA 48  400 400 ALA ALA A . n 
A 1 49  VAL 49  401 401 VAL VAL A . n 
A 1 50  LYS 50  402 402 LYS LYS A . n 
A 1 51  ILE 51  403 403 ILE ILE A . n 
A 1 52  LEU 52  404 404 LEU LEU A . n 
A 1 53  LYS 53  405 405 LYS LYS A . n 
A 1 54  ASN 54  406 406 ASN ASN A . n 
A 1 55  GLU 55  407 407 GLU GLU A . n 
A 1 56  ALA 56  408 408 ALA ALA A . n 
A 1 57  ASN 57  409 409 ASN ASN A . n 
A 1 58  ASP 58  410 410 ASP ASP A . n 
A 1 59  PRO 59  411 411 PRO PRO A . n 
A 1 60  ALA 60  412 412 ALA ALA A . n 
A 1 61  LEU 61  413 413 LEU LEU A . n 
A 1 62  LYS 62  414 414 LYS LYS A . n 
A 1 63  ASP 63  415 415 ASP ASP A . n 
A 1 64  GLU 64  416 416 GLU GLU A . n 
A 1 65  LEU 65  417 417 LEU LEU A . n 
A 1 66  LEU 66  418 418 LEU LEU A . n 
A 1 67  ALA 67  419 419 ALA ALA A . n 
A 1 68  GLU 68  420 420 GLU GLU A . n 
A 1 69  ALA 69  421 421 ALA ALA A . n 
A 1 70  ASN 70  422 422 ASN ASN A . n 
A 1 71  VAL 71  423 423 VAL VAL A . n 
A 1 72  MET 72  424 424 MET MET A . n 
A 1 73  GLN 73  425 425 GLN GLN A . n 
A 1 74  GLN 74  426 426 GLN GLN A . n 
A 1 75  LEU 75  427 427 LEU LEU A . n 
A 1 76  ASP 76  428 428 ASP ASP A . n 
A 1 77  ASN 77  429 429 ASN ASN A . n 
A 1 78  PRO 78  430 430 PRO PRO A . n 
A 1 79  TYR 79  431 431 TYR TYR A . n 
A 1 80  ILE 80  432 432 ILE ILE A . n 
A 1 81  VAL 81  433 433 VAL VAL A . n 
A 1 82  ARG 82  434 434 ARG ARG A . n 
A 1 83  MET 83  435 435 MET MET A . n 
A 1 84  ILE 84  436 436 ILE ILE A . n 
A 1 85  GLY 85  437 437 GLY GLY A . n 
A 1 86  ILE 86  438 438 ILE ILE A . n 
A 1 87  CYS 87  439 439 CYS CYS A . n 
A 1 88  GLU 88  440 440 GLU GLU A . n 
A 1 89  ALA 89  441 441 ALA ALA A . n 
A 1 90  GLU 90  442 442 GLU GLU A . n 
A 1 91  SER 91  443 443 SER SER A . n 
A 1 92  TRP 92  444 444 TRP TRP A . n 
A 1 93  MET 93  445 445 MET MET A . n 
A 1 94  LEU 94  446 446 LEU LEU A . n 
A 1 95  VAL 95  447 447 VAL VAL A . n 
A 1 96  MET 96  448 448 MET MET A . n 
A 1 97  GLU 97  449 449 GLU GLU A . n 
A 1 98  MET 98  450 450 MET MET A . n 
A 1 99  ALA 99  451 451 ALA ALA A . n 
A 1 100 GLU 100 452 452 GLU GLU A . n 
A 1 101 LEU 101 453 453 LEU LEU A . n 
A 1 102 GLY 102 454 454 GLY GLY A . n 
A 1 103 PRO 103 455 455 PRO PRO A . n 
A 1 104 LEU 104 456 456 LEU LEU A . n 
A 1 105 ASN 105 457 457 ASN ASN A . n 
A 1 106 LYS 106 458 458 LYS LYS A . n 
A 1 107 TYR 107 459 459 TYR TYR A . n 
A 1 108 LEU 108 460 460 LEU LEU A . n 
A 1 109 GLN 109 461 461 GLN GLN A . n 
A 1 110 GLN 110 462 462 GLN GLN A . n 
A 1 111 ASN 111 463 463 ASN ASN A . n 
A 1 112 ARG 112 464 464 ARG ARG A . n 
A 1 113 HIS 113 465 465 HIS HIS A . n 
A 1 114 VAL 114 466 466 VAL VAL A . n 
A 1 115 LYS 115 467 467 LYS LYS A . n 
A 1 116 ASP 116 468 468 ASP ASP A . n 
A 1 117 LYS 117 469 469 LYS LYS A . n 
A 1 118 ASN 118 470 470 ASN ASN A . n 
A 1 119 ILE 119 471 471 ILE ILE A . n 
A 1 120 ILE 120 472 472 ILE ILE A . n 
A 1 121 GLU 121 473 473 GLU GLU A . n 
A 1 122 LEU 122 474 474 LEU LEU A . n 
A 1 123 VAL 123 475 475 VAL VAL A . n 
A 1 124 HIS 124 476 476 HIS HIS A . n 
A 1 125 GLN 125 477 477 GLN GLN A . n 
A 1 126 VAL 126 478 478 VAL VAL A . n 
A 1 127 SER 127 479 479 SER SER A . n 
A 1 128 MET 128 480 480 MET MET A . n 
A 1 129 GLY 129 481 481 GLY GLY A . n 
A 1 130 MET 130 482 482 MET MET A . n 
A 1 131 LYS 131 483 483 LYS LYS A . n 
A 1 132 TYR 132 484 484 TYR TYR A . n 
A 1 133 LEU 133 485 485 LEU LEU A . n 
A 1 134 GLU 134 486 486 GLU GLU A . n 
A 1 135 GLU 135 487 487 GLU GLU A . n 
A 1 136 SER 136 488 488 SER SER A . n 
A 1 137 ASN 137 489 489 ASN ASN A . n 
A 1 138 PHE 138 490 490 PHE PHE A . n 
A 1 139 VAL 139 491 491 VAL VAL A . n 
A 1 140 HIS 140 492 492 HIS HIS A . n 
A 1 141 ARG 141 493 493 ARG ARG A . n 
A 1 142 ASP 142 494 494 ASP ASP A . n 
A 1 143 LEU 143 495 495 LEU LEU A . n 
A 1 144 ALA 144 496 496 ALA ALA A . n 
A 1 145 ALA 145 497 497 ALA ALA A . n 
A 1 146 ARG 146 498 498 ARG ARG A . n 
A 1 147 ASN 147 499 499 ASN ASN A . n 
A 1 148 VAL 148 500 500 VAL VAL A . n 
A 1 149 LEU 149 501 501 LEU LEU A . n 
A 1 150 LEU 150 502 502 LEU LEU A . n 
A 1 151 VAL 151 503 503 VAL VAL A . n 
A 1 152 THR 152 504 504 THR THR A . n 
A 1 153 GLN 153 505 505 GLN GLN A . n 
A 1 154 HIS 154 506 506 HIS HIS A . n 
A 1 155 TYR 155 507 507 TYR TYR A . n 
A 1 156 ALA 156 508 508 ALA ALA A . n 
A 1 157 LYS 157 509 509 LYS LYS A . n 
A 1 158 ILE 158 510 510 ILE ILE A . n 
A 1 159 SER 159 511 511 SER SER A . n 
A 1 160 ASP 160 512 512 ASP ASP A . n 
A 1 161 PHE 161 513 513 PHE PHE A . n 
A 1 162 GLY 162 514 514 GLY GLY A . n 
A 1 163 LEU 163 515 515 LEU LEU A . n 
A 1 164 SER 164 516 516 SER SER A . n 
A 1 165 LYS 165 517 517 LYS LYS A . n 
A 1 166 ALA 166 518 518 ALA ALA A . n 
A 1 167 LEU 167 519 519 LEU LEU A . n 
A 1 168 ARG 168 520 520 ARG ARG A . n 
A 1 169 ALA 169 521 521 ALA ALA A . n 
A 1 170 ASP 170 522 522 ASP ASP A . n 
A 1 171 GLU 171 523 523 GLU GLU A . n 
A 1 172 ASN 172 524 524 ASN ASN A . n 
A 1 173 TYR 173 525 525 TYR TYR A . n 
A 1 174 TYR 174 526 526 TYR TYR A . n 
A 1 175 LYS 175 527 527 LYS LYS A . n 
A 1 176 ALA 176 528 528 ALA ALA A . n 
A 1 177 GLN 177 529 ?   ?   ?   A . n 
A 1 178 THR 178 530 ?   ?   ?   A . n 
A 1 179 HIS 179 531 ?   ?   ?   A . n 
A 1 180 GLY 180 532 ?   ?   ?   A . n 
A 1 181 LYS 181 533 ?   ?   ?   A . n 
A 1 182 TRP 182 534 ?   ?   ?   A . n 
A 1 183 PRO 183 535 535 PRO PRO A . n 
A 1 184 VAL 184 536 536 VAL VAL A . n 
A 1 185 LYS 185 537 537 LYS LYS A . n 
A 1 186 TRP 186 538 538 TRP TRP A . n 
A 1 187 TYR 187 539 539 TYR TYR A . n 
A 1 188 ALA 188 540 540 ALA ALA A . n 
A 1 189 PRO 189 541 541 PRO PRO A . n 
A 1 190 GLU 190 542 542 GLU GLU A . n 
A 1 191 CYS 191 543 543 CYS CYS A . n 
A 1 192 ILE 192 544 544 ILE ILE A . n 
A 1 193 ASN 193 545 545 ASN ASN A . n 
A 1 194 TYR 194 546 546 TYR TYR A . n 
A 1 195 TYR 195 547 547 TYR TYR A . n 
A 1 196 LYS 196 548 548 LYS LYS A . n 
A 1 197 PHE 197 549 549 PHE PHE A . n 
A 1 198 SER 198 550 550 SER SER A . n 
A 1 199 SER 199 551 551 SER SER A . n 
A 1 200 LYS 200 552 552 LYS LYS A . n 
A 1 201 SER 201 553 553 SER SER A . n 
A 1 202 ASP 202 554 554 ASP ASP A . n 
A 1 203 VAL 203 555 555 VAL VAL A . n 
A 1 204 TRP 204 556 556 TRP TRP A . n 
A 1 205 SER 205 557 557 SER SER A . n 
A 1 206 PHE 206 558 558 PHE PHE A . n 
A 1 207 GLY 207 559 559 GLY GLY A . n 
A 1 208 VAL 208 560 560 VAL VAL A . n 
A 1 209 LEU 209 561 561 LEU LEU A . n 
A 1 210 MET 210 562 562 MET MET A . n 
A 1 211 TRP 211 563 563 TRP TRP A . n 
A 1 212 GLU 212 564 564 GLU GLU A . n 
A 1 213 ALA 213 565 565 ALA ALA A . n 
A 1 214 PHE 214 566 566 PHE PHE A . n 
A 1 215 SER 215 567 567 SER SER A . n 
A 1 216 TYR 216 568 568 TYR TYR A . n 
A 1 217 GLY 217 569 569 GLY GLY A . n 
A 1 218 GLN 218 570 570 GLN GLN A . n 
A 1 219 LYS 219 571 571 LYS LYS A . n 
A 1 220 PRO 220 572 572 PRO PRO A . n 
A 1 221 TYR 221 573 573 TYR TYR A . n 
A 1 222 ARG 222 574 574 ARG ARG A . n 
A 1 223 GLY 223 575 575 GLY GLY A . n 
A 1 224 MET 224 576 576 MET MET A . n 
A 1 225 LYS 225 577 577 LYS LYS A . n 
A 1 226 GLY 226 578 578 GLY GLY A . n 
A 1 227 SER 227 579 579 SER SER A . n 
A 1 228 GLU 228 580 580 GLU GLU A . n 
A 1 229 VAL 229 581 581 VAL VAL A . n 
A 1 230 THR 230 582 582 THR THR A . n 
A 1 231 ALA 231 583 583 ALA ALA A . n 
A 1 232 MET 232 584 584 MET MET A . n 
A 1 233 LEU 233 585 585 LEU LEU A . n 
A 1 234 GLU 234 586 586 GLU GLU A . n 
A 1 235 LYS 235 587 587 LYS LYS A . n 
A 1 236 GLY 236 588 588 GLY GLY A . n 
A 1 237 GLU 237 589 589 GLU GLU A . n 
A 1 238 ARG 238 590 590 ARG ARG A . n 
A 1 239 MET 239 591 591 MET MET A . n 
A 1 240 GLY 240 592 592 GLY GLY A . n 
A 1 241 CYS 241 593 593 CYS CYS A . n 
A 1 242 PRO 242 594 594 PRO PRO A . n 
A 1 243 ALA 243 595 595 ALA ALA A . n 
A 1 244 GLY 244 596 596 GLY GLY A . n 
A 1 245 CYS 245 597 597 CYS CYS A . n 
A 1 246 PRO 246 598 598 PRO PRO A . n 
A 1 247 ARG 247 599 599 ARG ARG A . n 
A 1 248 GLU 248 600 600 GLU GLU A . n 
A 1 249 MET 249 601 601 MET MET A . n 
A 1 250 TYR 250 602 602 TYR TYR A . n 
A 1 251 ASP 251 603 603 ASP ASP A . n 
A 1 252 LEU 252 604 604 LEU LEU A . n 
A 1 253 MET 253 605 605 MET MET A . n 
A 1 254 ASN 254 606 606 ASN ASN A . n 
A 1 255 LEU 255 607 607 LEU LEU A . n 
A 1 256 CYS 256 608 608 CYS CYS A . n 
A 1 257 TRP 257 609 609 TRP TRP A . n 
A 1 258 THR 258 610 610 THR THR A . n 
A 1 259 TYR 259 611 611 TYR TYR A . n 
A 1 260 ASP 260 612 612 ASP ASP A . n 
A 1 261 VAL 261 613 613 VAL VAL A . n 
A 1 262 GLU 262 614 614 GLU GLU A . n 
A 1 263 ASN 263 615 615 ASN ASN A . n 
A 1 264 ARG 264 616 616 ARG ARG A . n 
A 1 265 PRO 265 617 617 PRO PRO A . n 
A 1 266 GLY 266 618 618 GLY GLY A . n 
A 1 267 PHE 267 619 619 PHE PHE A . n 
A 1 268 ALA 268 620 620 ALA ALA A . n 
A 1 269 ALA 269 621 621 ALA ALA A . n 
A 1 270 VAL 270 622 622 VAL VAL A . n 
A 1 271 GLU 271 623 623 GLU GLU A . n 
A 1 272 LEU 272 624 624 LEU LEU A . n 
A 1 273 ARG 273 625 625 ARG ARG A . n 
A 1 274 LEU 274 626 626 LEU LEU A . n 
A 1 275 ARG 275 627 627 ARG ARG A . n 
A 1 276 ASN 276 628 628 ASN ASN A . n 
A 1 277 TYR 277 629 629 TYR TYR A . n 
A 1 278 TYR 278 630 630 TYR TYR A . n 
A 1 279 TYR 279 631 631 TYR TYR A . n 
A 1 280 ASP 280 632 632 ASP ASP A . n 
A 1 281 VAL 281 633 633 VAL VAL A . n 
A 1 282 VAL 282 634 ?   ?   ?   A . n 
A 1 283 ASN 283 635 ?   ?   ?   A . n 
A 1 284 LEU 284 636 ?   ?   ?   A . n 
A 1 285 GLU 285 637 ?   ?   ?   A . n 
A 1 286 HIS 286 638 ?   ?   ?   A . n 
A 1 287 HIS 287 639 ?   ?   ?   A . n 
A 1 288 HIS 288 640 ?   ?   ?   A . n 
A 1 289 HIS 289 641 ?   ?   ?   A . n 
A 1 290 HIS 290 642 ?   ?   ?   A . n 
A 1 291 HIS 291 643 ?   ?   ?   A . n 
A 1 292 HIS 292 644 ?   ?   ?   A . n 
A 1 293 HIS 293 645 ?   ?   ?   A . n 
B 1 1   MET 1   353 ?   ?   ?   B . n 
B 1 2   ALA 2   354 ?   ?   ?   B . n 
B 1 3   LEU 3   355 ?   ?   ?   B . n 
B 1 4   GLU 4   356 ?   ?   ?   B . n 
B 1 5   GLU 5   357 ?   ?   ?   B . n 
B 1 6   ILE 6   358 ?   ?   ?   B . n 
B 1 7   ARG 7   359 ?   ?   ?   B . n 
B 1 8   PRO 8   360 ?   ?   ?   B . n 
B 1 9   LYS 9   361 ?   ?   ?   B . n 
B 1 10  GLU 10  362 ?   ?   ?   B . n 
B 1 11  VAL 11  363 ?   ?   ?   B . n 
B 1 12  TYR 12  364 ?   ?   ?   B . n 
B 1 13  LEU 13  365 365 LEU LEU B . n 
B 1 14  ASP 14  366 366 ASP ASP B . n 
B 1 15  ARG 15  367 367 ARG ARG B . n 
B 1 16  LYS 16  368 368 LYS LYS B . n 
B 1 17  LEU 17  369 369 LEU LEU B . n 
B 1 18  LEU 18  370 370 LEU LEU B . n 
B 1 19  THR 19  371 371 THR THR B . n 
B 1 20  LEU 20  372 372 LEU LEU B . n 
B 1 21  GLU 21  373 373 GLU GLU B . n 
B 1 22  ASP 22  374 374 ASP ASP B . n 
B 1 23  LYS 23  375 375 LYS LYS B . n 
B 1 24  GLU 24  376 376 GLU GLU B . n 
B 1 25  LEU 25  377 377 LEU LEU B . n 
B 1 26  GLY 26  378 378 GLY GLY B . n 
B 1 27  SER 27  379 379 SER SER B . n 
B 1 28  GLY 28  380 380 GLY GLY B . n 
B 1 29  ASN 29  381 381 ASN ASN B . n 
B 1 30  PHE 30  382 382 PHE PHE B . n 
B 1 31  GLY 31  383 383 GLY GLY B . n 
B 1 32  THR 32  384 384 THR THR B . n 
B 1 33  VAL 33  385 385 VAL VAL B . n 
B 1 34  LYS 34  386 386 LYS LYS B . n 
B 1 35  LYS 35  387 387 LYS LYS B . n 
B 1 36  GLY 36  388 388 GLY GLY B . n 
B 1 37  TYR 37  389 389 TYR TYR B . n 
B 1 38  TYR 38  390 390 TYR TYR B . n 
B 1 39  GLN 39  391 391 GLN GLN B . n 
B 1 40  MET 40  392 392 MET MET B . n 
B 1 41  LYS 41  393 393 LYS LYS B . n 
B 1 42  LYS 42  394 394 LYS LYS B . n 
B 1 43  VAL 43  395 395 VAL VAL B . n 
B 1 44  VAL 44  396 396 VAL VAL B . n 
B 1 45  LYS 45  397 397 LYS LYS B . n 
B 1 46  THR 46  398 398 THR THR B . n 
B 1 47  VAL 47  399 399 VAL VAL B . n 
B 1 48  ALA 48  400 400 ALA ALA B . n 
B 1 49  VAL 49  401 401 VAL VAL B . n 
B 1 50  LYS 50  402 402 LYS LYS B . n 
B 1 51  ILE 51  403 403 ILE ILE B . n 
B 1 52  LEU 52  404 404 LEU LEU B . n 
B 1 53  LYS 53  405 405 LYS LYS B . n 
B 1 54  ASN 54  406 406 ASN ASN B . n 
B 1 55  GLU 55  407 407 GLU GLU B . n 
B 1 56  ALA 56  408 408 ALA ALA B . n 
B 1 57  ASN 57  409 409 ASN ASN B . n 
B 1 58  ASP 58  410 410 ASP ASP B . n 
B 1 59  PRO 59  411 411 PRO PRO B . n 
B 1 60  ALA 60  412 412 ALA ALA B . n 
B 1 61  LEU 61  413 413 LEU LEU B . n 
B 1 62  LYS 62  414 414 LYS LYS B . n 
B 1 63  ASP 63  415 415 ASP ASP B . n 
B 1 64  GLU 64  416 416 GLU GLU B . n 
B 1 65  LEU 65  417 417 LEU LEU B . n 
B 1 66  LEU 66  418 418 LEU LEU B . n 
B 1 67  ALA 67  419 419 ALA ALA B . n 
B 1 68  GLU 68  420 420 GLU GLU B . n 
B 1 69  ALA 69  421 421 ALA ALA B . n 
B 1 70  ASN 70  422 422 ASN ASN B . n 
B 1 71  VAL 71  423 423 VAL VAL B . n 
B 1 72  MET 72  424 424 MET MET B . n 
B 1 73  GLN 73  425 425 GLN GLN B . n 
B 1 74  GLN 74  426 426 GLN GLN B . n 
B 1 75  LEU 75  427 427 LEU LEU B . n 
B 1 76  ASP 76  428 428 ASP ASP B . n 
B 1 77  ASN 77  429 429 ASN ASN B . n 
B 1 78  PRO 78  430 430 PRO PRO B . n 
B 1 79  TYR 79  431 431 TYR TYR B . n 
B 1 80  ILE 80  432 432 ILE ILE B . n 
B 1 81  VAL 81  433 433 VAL VAL B . n 
B 1 82  ARG 82  434 434 ARG ARG B . n 
B 1 83  MET 83  435 435 MET MET B . n 
B 1 84  ILE 84  436 436 ILE ILE B . n 
B 1 85  GLY 85  437 437 GLY GLY B . n 
B 1 86  ILE 86  438 438 ILE ILE B . n 
B 1 87  CYS 87  439 439 CYS CYS B . n 
B 1 88  GLU 88  440 440 GLU GLU B . n 
B 1 89  ALA 89  441 441 ALA ALA B . n 
B 1 90  GLU 90  442 442 GLU GLU B . n 
B 1 91  SER 91  443 443 SER SER B . n 
B 1 92  TRP 92  444 444 TRP TRP B . n 
B 1 93  MET 93  445 445 MET MET B . n 
B 1 94  LEU 94  446 446 LEU LEU B . n 
B 1 95  VAL 95  447 447 VAL VAL B . n 
B 1 96  MET 96  448 448 MET MET B . n 
B 1 97  GLU 97  449 449 GLU GLU B . n 
B 1 98  MET 98  450 450 MET MET B . n 
B 1 99  ALA 99  451 451 ALA ALA B . n 
B 1 100 GLU 100 452 452 GLU GLU B . n 
B 1 101 LEU 101 453 453 LEU LEU B . n 
B 1 102 GLY 102 454 454 GLY GLY B . n 
B 1 103 PRO 103 455 455 PRO PRO B . n 
B 1 104 LEU 104 456 456 LEU LEU B . n 
B 1 105 ASN 105 457 457 ASN ASN B . n 
B 1 106 LYS 106 458 458 LYS LYS B . n 
B 1 107 TYR 107 459 459 TYR TYR B . n 
B 1 108 LEU 108 460 460 LEU LEU B . n 
B 1 109 GLN 109 461 461 GLN GLN B . n 
B 1 110 GLN 110 462 462 GLN GLN B . n 
B 1 111 ASN 111 463 463 ASN ASN B . n 
B 1 112 ARG 112 464 464 ARG ARG B . n 
B 1 113 HIS 113 465 465 HIS HIS B . n 
B 1 114 VAL 114 466 466 VAL VAL B . n 
B 1 115 LYS 115 467 467 LYS LYS B . n 
B 1 116 ASP 116 468 468 ASP ASP B . n 
B 1 117 LYS 117 469 469 LYS LYS B . n 
B 1 118 ASN 118 470 470 ASN ASN B . n 
B 1 119 ILE 119 471 471 ILE ILE B . n 
B 1 120 ILE 120 472 472 ILE ILE B . n 
B 1 121 GLU 121 473 473 GLU GLU B . n 
B 1 122 LEU 122 474 474 LEU LEU B . n 
B 1 123 VAL 123 475 475 VAL VAL B . n 
B 1 124 HIS 124 476 476 HIS HIS B . n 
B 1 125 GLN 125 477 477 GLN GLN B . n 
B 1 126 VAL 126 478 478 VAL VAL B . n 
B 1 127 SER 127 479 479 SER SER B . n 
B 1 128 MET 128 480 480 MET MET B . n 
B 1 129 GLY 129 481 481 GLY GLY B . n 
B 1 130 MET 130 482 482 MET MET B . n 
B 1 131 LYS 131 483 483 LYS LYS B . n 
B 1 132 TYR 132 484 484 TYR TYR B . n 
B 1 133 LEU 133 485 485 LEU LEU B . n 
B 1 134 GLU 134 486 486 GLU GLU B . n 
B 1 135 GLU 135 487 487 GLU GLU B . n 
B 1 136 SER 136 488 488 SER SER B . n 
B 1 137 ASN 137 489 489 ASN ASN B . n 
B 1 138 PHE 138 490 490 PHE PHE B . n 
B 1 139 VAL 139 491 491 VAL VAL B . n 
B 1 140 HIS 140 492 492 HIS HIS B . n 
B 1 141 ARG 141 493 493 ARG ARG B . n 
B 1 142 ASP 142 494 494 ASP ASP B . n 
B 1 143 LEU 143 495 495 LEU LEU B . n 
B 1 144 ALA 144 496 496 ALA ALA B . n 
B 1 145 ALA 145 497 497 ALA ALA B . n 
B 1 146 ARG 146 498 498 ARG ARG B . n 
B 1 147 ASN 147 499 499 ASN ASN B . n 
B 1 148 VAL 148 500 500 VAL VAL B . n 
B 1 149 LEU 149 501 501 LEU LEU B . n 
B 1 150 LEU 150 502 502 LEU LEU B . n 
B 1 151 VAL 151 503 503 VAL VAL B . n 
B 1 152 THR 152 504 504 THR THR B . n 
B 1 153 GLN 153 505 505 GLN GLN B . n 
B 1 154 HIS 154 506 506 HIS HIS B . n 
B 1 155 TYR 155 507 507 TYR TYR B . n 
B 1 156 ALA 156 508 508 ALA ALA B . n 
B 1 157 LYS 157 509 509 LYS LYS B . n 
B 1 158 ILE 158 510 510 ILE ILE B . n 
B 1 159 SER 159 511 511 SER SER B . n 
B 1 160 ASP 160 512 512 ASP ASP B . n 
B 1 161 PHE 161 513 513 PHE PHE B . n 
B 1 162 GLY 162 514 514 GLY GLY B . n 
B 1 163 LEU 163 515 515 LEU LEU B . n 
B 1 164 SER 164 516 516 SER SER B . n 
B 1 165 LYS 165 517 517 LYS LYS B . n 
B 1 166 ALA 166 518 518 ALA ALA B . n 
B 1 167 LEU 167 519 519 LEU LEU B . n 
B 1 168 ARG 168 520 520 ARG ARG B . n 
B 1 169 ALA 169 521 521 ALA ALA B . n 
B 1 170 ASP 170 522 522 ASP ASP B . n 
B 1 171 GLU 171 523 523 GLU GLU B . n 
B 1 172 ASN 172 524 524 ASN ASN B . n 
B 1 173 TYR 173 525 525 TYR TYR B . n 
B 1 174 TYR 174 526 526 TYR TYR B . n 
B 1 175 LYS 175 527 527 LYS LYS B . n 
B 1 176 ALA 176 528 528 ALA ALA B . n 
B 1 177 GLN 177 529 ?   ?   ?   B . n 
B 1 178 THR 178 530 ?   ?   ?   B . n 
B 1 179 HIS 179 531 ?   ?   ?   B . n 
B 1 180 GLY 180 532 ?   ?   ?   B . n 
B 1 181 LYS 181 533 ?   ?   ?   B . n 
B 1 182 TRP 182 534 ?   ?   ?   B . n 
B 1 183 PRO 183 535 535 PRO PRO B . n 
B 1 184 VAL 184 536 536 VAL VAL B . n 
B 1 185 LYS 185 537 537 LYS LYS B . n 
B 1 186 TRP 186 538 538 TRP TRP B . n 
B 1 187 TYR 187 539 539 TYR TYR B . n 
B 1 188 ALA 188 540 540 ALA ALA B . n 
B 1 189 PRO 189 541 541 PRO PRO B . n 
B 1 190 GLU 190 542 542 GLU GLU B . n 
B 1 191 CYS 191 543 543 CYS CYS B . n 
B 1 192 ILE 192 544 544 ILE ILE B . n 
B 1 193 ASN 193 545 545 ASN ASN B . n 
B 1 194 TYR 194 546 546 TYR TYR B . n 
B 1 195 TYR 195 547 547 TYR TYR B . n 
B 1 196 LYS 196 548 548 LYS LYS B . n 
B 1 197 PHE 197 549 549 PHE PHE B . n 
B 1 198 SER 198 550 550 SER SER B . n 
B 1 199 SER 199 551 551 SER SER B . n 
B 1 200 LYS 200 552 552 LYS LYS B . n 
B 1 201 SER 201 553 553 SER SER B . n 
B 1 202 ASP 202 554 554 ASP ASP B . n 
B 1 203 VAL 203 555 555 VAL VAL B . n 
B 1 204 TRP 204 556 556 TRP TRP B . n 
B 1 205 SER 205 557 557 SER SER B . n 
B 1 206 PHE 206 558 558 PHE PHE B . n 
B 1 207 GLY 207 559 559 GLY GLY B . n 
B 1 208 VAL 208 560 560 VAL VAL B . n 
B 1 209 LEU 209 561 561 LEU LEU B . n 
B 1 210 MET 210 562 562 MET MET B . n 
B 1 211 TRP 211 563 563 TRP TRP B . n 
B 1 212 GLU 212 564 564 GLU GLU B . n 
B 1 213 ALA 213 565 565 ALA ALA B . n 
B 1 214 PHE 214 566 566 PHE PHE B . n 
B 1 215 SER 215 567 567 SER SER B . n 
B 1 216 TYR 216 568 568 TYR TYR B . n 
B 1 217 GLY 217 569 569 GLY GLY B . n 
B 1 218 GLN 218 570 570 GLN GLN B . n 
B 1 219 LYS 219 571 571 LYS LYS B . n 
B 1 220 PRO 220 572 572 PRO PRO B . n 
B 1 221 TYR 221 573 573 TYR TYR B . n 
B 1 222 ARG 222 574 574 ARG ARG B . n 
B 1 223 GLY 223 575 575 GLY GLY B . n 
B 1 224 MET 224 576 576 MET MET B . n 
B 1 225 LYS 225 577 577 LYS LYS B . n 
B 1 226 GLY 226 578 578 GLY GLY B . n 
B 1 227 SER 227 579 579 SER SER B . n 
B 1 228 GLU 228 580 580 GLU GLU B . n 
B 1 229 VAL 229 581 581 VAL VAL B . n 
B 1 230 THR 230 582 582 THR THR B . n 
B 1 231 ALA 231 583 583 ALA ALA B . n 
B 1 232 MET 232 584 584 MET MET B . n 
B 1 233 LEU 233 585 585 LEU LEU B . n 
B 1 234 GLU 234 586 586 GLU GLU B . n 
B 1 235 LYS 235 587 587 LYS LYS B . n 
B 1 236 GLY 236 588 588 GLY GLY B . n 
B 1 237 GLU 237 589 589 GLU GLU B . n 
B 1 238 ARG 238 590 590 ARG ARG B . n 
B 1 239 MET 239 591 591 MET MET B . n 
B 1 240 GLY 240 592 592 GLY GLY B . n 
B 1 241 CYS 241 593 593 CYS CYS B . n 
B 1 242 PRO 242 594 594 PRO PRO B . n 
B 1 243 ALA 243 595 595 ALA ALA B . n 
B 1 244 GLY 244 596 596 GLY GLY B . n 
B 1 245 CYS 245 597 597 CYS CYS B . n 
B 1 246 PRO 246 598 598 PRO PRO B . n 
B 1 247 ARG 247 599 599 ARG ARG B . n 
B 1 248 GLU 248 600 600 GLU GLU B . n 
B 1 249 MET 249 601 601 MET MET B . n 
B 1 250 TYR 250 602 602 TYR TYR B . n 
B 1 251 ASP 251 603 603 ASP ASP B . n 
B 1 252 LEU 252 604 604 LEU LEU B . n 
B 1 253 MET 253 605 605 MET MET B . n 
B 1 254 ASN 254 606 606 ASN ASN B . n 
B 1 255 LEU 255 607 607 LEU LEU B . n 
B 1 256 CYS 256 608 608 CYS CYS B . n 
B 1 257 TRP 257 609 609 TRP TRP B . n 
B 1 258 THR 258 610 610 THR THR B . n 
B 1 259 TYR 259 611 611 TYR TYR B . n 
B 1 260 ASP 260 612 612 ASP ASP B . n 
B 1 261 VAL 261 613 613 VAL VAL B . n 
B 1 262 GLU 262 614 614 GLU GLU B . n 
B 1 263 ASN 263 615 615 ASN ASN B . n 
B 1 264 ARG 264 616 616 ARG ARG B . n 
B 1 265 PRO 265 617 617 PRO PRO B . n 
B 1 266 GLY 266 618 618 GLY GLY B . n 
B 1 267 PHE 267 619 619 PHE PHE B . n 
B 1 268 ALA 268 620 620 ALA ALA B . n 
B 1 269 ALA 269 621 621 ALA ALA B . n 
B 1 270 VAL 270 622 622 VAL VAL B . n 
B 1 271 GLU 271 623 623 GLU GLU B . n 
B 1 272 LEU 272 624 624 LEU LEU B . n 
B 1 273 ARG 273 625 625 ARG ARG B . n 
B 1 274 LEU 274 626 626 LEU LEU B . n 
B 1 275 ARG 275 627 627 ARG ARG B . n 
B 1 276 ASN 276 628 628 ASN ASN B . n 
B 1 277 TYR 277 629 629 TYR TYR B . n 
B 1 278 TYR 278 630 630 TYR TYR B . n 
B 1 279 TYR 279 631 631 TYR TYR B . n 
B 1 280 ASP 280 632 632 ASP ASP B . n 
B 1 281 VAL 281 633 633 VAL VAL B . n 
B 1 282 VAL 282 634 ?   ?   ?   B . n 
B 1 283 ASN 283 635 ?   ?   ?   B . n 
B 1 284 LEU 284 636 ?   ?   ?   B . n 
B 1 285 GLU 285 637 ?   ?   ?   B . n 
B 1 286 HIS 286 638 ?   ?   ?   B . n 
B 1 287 HIS 287 639 ?   ?   ?   B . n 
B 1 288 HIS 288 640 ?   ?   ?   B . n 
B 1 289 HIS 289 641 ?   ?   ?   B . n 
B 1 290 HIS 290 642 ?   ?   ?   B . n 
B 1 291 HIS 291 643 ?   ?   ?   B . n 
B 1 292 HIS 292 644 ?   ?   ?   B . n 
B 1 293 HIS 293 645 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        XFB 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   XFB 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 XFB 1  701 701 XFB UNK A . 
D 3 GOL 1  702 801 GOL GOL A . 
E 2 XFB 1  701 701 XFB UNK B . 
F 4 HOH 1  801 35  HOH HOH A . 
F 4 HOH 2  802 28  HOH HOH A . 
F 4 HOH 3  803 89  HOH HOH A . 
F 4 HOH 4  804 79  HOH HOH A . 
F 4 HOH 5  805 36  HOH HOH A . 
F 4 HOH 6  806 60  HOH HOH A . 
F 4 HOH 7  807 77  HOH HOH A . 
F 4 HOH 8  808 3   HOH HOH A . 
F 4 HOH 9  809 6   HOH HOH A . 
F 4 HOH 10 810 88  HOH HOH A . 
F 4 HOH 11 811 32  HOH HOH A . 
F 4 HOH 12 812 104 HOH HOH A . 
F 4 HOH 13 813 30  HOH HOH A . 
F 4 HOH 14 814 4   HOH HOH A . 
F 4 HOH 15 815 98  HOH HOH A . 
F 4 HOH 16 816 65  HOH HOH A . 
F 4 HOH 17 817 64  HOH HOH A . 
F 4 HOH 18 818 42  HOH HOH A . 
F 4 HOH 19 819 37  HOH HOH A . 
F 4 HOH 20 820 63  HOH HOH A . 
F 4 HOH 21 821 33  HOH HOH A . 
F 4 HOH 22 822 25  HOH HOH A . 
F 4 HOH 23 823 90  HOH HOH A . 
F 4 HOH 24 824 91  HOH HOH A . 
F 4 HOH 25 825 7   HOH HOH A . 
F 4 HOH 26 826 92  HOH HOH A . 
F 4 HOH 27 827 76  HOH HOH A . 
F 4 HOH 28 828 68  HOH HOH A . 
F 4 HOH 29 829 5   HOH HOH A . 
F 4 HOH 30 830 112 HOH HOH A . 
F 4 HOH 31 831 40  HOH HOH A . 
F 4 HOH 32 832 14  HOH HOH A . 
F 4 HOH 33 833 38  HOH HOH A . 
F 4 HOH 34 834 111 HOH HOH A . 
F 4 HOH 35 835 87  HOH HOH A . 
F 4 HOH 36 836 75  HOH HOH A . 
F 4 HOH 37 837 105 HOH HOH A . 
F 4 HOH 38 838 27  HOH HOH A . 
F 4 HOH 39 839 69  HOH HOH A . 
F 4 HOH 40 840 10  HOH HOH A . 
F 4 HOH 41 841 39  HOH HOH A . 
F 4 HOH 42 842 78  HOH HOH A . 
F 4 HOH 43 843 29  HOH HOH A . 
F 4 HOH 44 844 23  HOH HOH A . 
F 4 HOH 45 845 82  HOH HOH A . 
F 4 HOH 46 846 31  HOH HOH A . 
F 4 HOH 47 847 41  HOH HOH A . 
F 4 HOH 48 848 86  HOH HOH A . 
F 4 HOH 49 849 34  HOH HOH A . 
F 4 HOH 50 850 107 HOH HOH A . 
F 4 HOH 51 851 80  HOH HOH A . 
F 4 HOH 52 852 109 HOH HOH A . 
F 4 HOH 53 853 44  HOH HOH A . 
F 4 HOH 54 854 110 HOH HOH A . 
F 4 HOH 55 855 108 HOH HOH A . 
F 4 HOH 56 856 61  HOH HOH A . 
G 4 HOH 1  801 67  HOH HOH B . 
G 4 HOH 2  802 46  HOH HOH B . 
G 4 HOH 3  803 21  HOH HOH B . 
G 4 HOH 4  804 8   HOH HOH B . 
G 4 HOH 5  805 73  HOH HOH B . 
G 4 HOH 6  806 15  HOH HOH B . 
G 4 HOH 7  807 17  HOH HOH B . 
G 4 HOH 8  808 22  HOH HOH B . 
G 4 HOH 9  809 1   HOH HOH B . 
G 4 HOH 10 810 85  HOH HOH B . 
G 4 HOH 11 811 13  HOH HOH B . 
G 4 HOH 12 812 11  HOH HOH B . 
G 4 HOH 13 813 45  HOH HOH B . 
G 4 HOH 14 814 50  HOH HOH B . 
G 4 HOH 15 815 106 HOH HOH B . 
G 4 HOH 16 816 48  HOH HOH B . 
G 4 HOH 17 817 12  HOH HOH B . 
G 4 HOH 18 818 72  HOH HOH B . 
G 4 HOH 19 819 53  HOH HOH B . 
G 4 HOH 20 820 2   HOH HOH B . 
G 4 HOH 21 821 100 HOH HOH B . 
G 4 HOH 22 822 59  HOH HOH B . 
G 4 HOH 23 823 26  HOH HOH B . 
G 4 HOH 24 824 24  HOH HOH B . 
G 4 HOH 25 825 55  HOH HOH B . 
G 4 HOH 26 826 19  HOH HOH B . 
G 4 HOH 27 827 52  HOH HOH B . 
G 4 HOH 28 828 102 HOH HOH B . 
G 4 HOH 29 829 20  HOH HOH B . 
G 4 HOH 30 830 16  HOH HOH B . 
G 4 HOH 31 831 99  HOH HOH B . 
G 4 HOH 32 832 83  HOH HOH B . 
G 4 HOH 33 833 54  HOH HOH B . 
G 4 HOH 34 834 56  HOH HOH B . 
G 4 HOH 35 835 62  HOH HOH B . 
G 4 HOH 36 836 9   HOH HOH B . 
G 4 HOH 37 837 58  HOH HOH B . 
G 4 HOH 38 838 51  HOH HOH B . 
G 4 HOH 39 839 103 HOH HOH B . 
G 4 HOH 40 840 49  HOH HOH B . 
G 4 HOH 41 841 18  HOH HOH B . 
G 4 HOH 42 842 74  HOH HOH B . 
G 4 HOH 43 843 93  HOH HOH B . 
G 4 HOH 44 844 101 HOH HOH B . 
G 4 HOH 45 845 94  HOH HOH B . 
G 4 HOH 46 846 57  HOH HOH B . 
G 4 HOH 47 847 97  HOH HOH B . 
G 4 HOH 48 848 96  HOH HOH B . 
G 4 HOH 49 849 84  HOH HOH B . 
G 4 HOH 50 850 95  HOH HOH B . 
G 4 HOH 51 851 47  HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP   ? ? ? .           4 
# 
_cell.angle_alpha                  90.034 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.027 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  94.811 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8WYW 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     39.719 
_cell.length_a_esd                 ? 
_cell.length_b                     39.602 
_cell.length_b_esd                 ? 
_cell.length_c                     88.355 
_cell.length_c_esd                 ? 
_cell.volume                       138488.465 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8WYW 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            'P 1' 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8WYW 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.02 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          39.22 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100mM Sodium-HEPES 7.0, 15%(v/v)PEG 4000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'ADSC QUANTUM 315r' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2016-05-03 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PAL/PLS BEAMLINE 5C (4A)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   '5C (4A)' 
_diffrn_source.pdbx_synchrotron_site       PAL/PLS 
# 
_reflns.B_iso_Wilson_estimate                          33.08 
_reflns.entry_id                                       8WYW 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.9 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     39698 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           94.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          22.94 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.877 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.90 
_reflns_shell.d_res_low                                     1.93 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1845 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.877 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               37.64 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8WYW 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             44.18 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     39690 
_refine.ls_number_reflns_R_free                  2009 
_refine.ls_number_reflns_R_work                  37681 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    94.16 
_refine.ls_percent_reflns_R_free                 5.06 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2020 
_refine.ls_R_factor_R_free                       0.2417 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1998 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.93 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.5326 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2325 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        44.18 
_refine_hist.number_atoms_solvent             107 
_refine_hist.number_atoms_total               4459 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4276 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         76 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0068  ? 4454 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8929  ? 6007 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0508  ? 623  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0066  ? 754  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.7767 ? 1676 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.90 1.95  . . 134 2492 88.33 . . . . 0.2274 . . . . . . . . . . . 0.2910 
'X-RAY DIFFRACTION' 1.95 2.00  . . 119 2707 94.17 . . . . 0.2265 . . . . . . . . . . . 0.2898 
'X-RAY DIFFRACTION' 2.00 2.06  . . 162 2718 94.74 . . . . 0.2215 . . . . . . . . . . . 0.2787 
'X-RAY DIFFRACTION' 2.06 2.13  . . 160 2634 94.74 . . . . 0.2110 . . . . . . . . . . . 0.2972 
'X-RAY DIFFRACTION' 2.13 2.20  . . 161 2780 95.05 . . . . 0.2075 . . . . . . . . . . . 0.2610 
'X-RAY DIFFRACTION' 2.20 2.29  . . 134 2692 95.31 . . . . 0.2034 . . . . . . . . . . . 0.2867 
'X-RAY DIFFRACTION' 2.29 2.40  . . 111 2747 95.30 . . . . 0.2032 . . . . . . . . . . . 0.2673 
'X-RAY DIFFRACTION' 2.40 2.52  . . 149 2791 96.36 . . . . 0.2026 . . . . . . . . . . . 0.2418 
'X-RAY DIFFRACTION' 2.52 2.68  . . 142 2771 96.87 . . . . 0.2125 . . . . . . . . . . . 0.2929 
'X-RAY DIFFRACTION' 2.68 2.89  . . 149 2765 97.04 . . . . 0.2097 . . . . . . . . . . . 0.2833 
'X-RAY DIFFRACTION' 2.89 3.18  . . 149 2740 96.46 . . . . 0.2175 . . . . . . . . . . . 0.2480 
'X-RAY DIFFRACTION' 3.18 3.64  . . 142 2740 94.46 . . . . 0.2029 . . . . . . . . . . . 0.2500 
'X-RAY DIFFRACTION' 3.64 4.58  . . 147 2474 87.45 . . . . 0.1853 . . . . . . . . . . . 0.2184 
'X-RAY DIFFRACTION' 4.58 44.18 . . 150 2630 91.93 . . . . 0.1805 . . . . . . . . . . . 0.1871 
# 
_struct.entry_id                     8WYW 
_struct.title                        
'Crystal structure of spleen tyrosine kinase (SYK) in complex with SKI-O-592 (free form of SKI-O-703, cevidoplenib)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8WYW 
_struct_keywords.text            'transferase, signal pathway, anticancer' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 4 ? 
G N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    KSYK_HUMAN 
_struct_ref.pdbx_db_accession          P43405 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM
IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL
SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA
GCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
;
_struct_ref.pdbx_align_begin           356 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8WYW A 4 ? 283 ? P43405 356 ? 635 ? 356 635 
2 1 8WYW B 4 ? 283 ? P43405 356 ? 635 ? 356 635 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8WYW MET A 1   ? UNP P43405 ? ? 'expression tag' 353 1  
1 8WYW ALA A 2   ? UNP P43405 ? ? 'expression tag' 354 2  
1 8WYW LEU A 3   ? UNP P43405 ? ? 'expression tag' 355 3  
1 8WYW LEU A 284 ? UNP P43405 ? ? 'expression tag' 636 4  
1 8WYW GLU A 285 ? UNP P43405 ? ? 'expression tag' 637 5  
1 8WYW HIS A 286 ? UNP P43405 ? ? 'expression tag' 638 6  
1 8WYW HIS A 287 ? UNP P43405 ? ? 'expression tag' 639 7  
1 8WYW HIS A 288 ? UNP P43405 ? ? 'expression tag' 640 8  
1 8WYW HIS A 289 ? UNP P43405 ? ? 'expression tag' 641 9  
1 8WYW HIS A 290 ? UNP P43405 ? ? 'expression tag' 642 10 
1 8WYW HIS A 291 ? UNP P43405 ? ? 'expression tag' 643 11 
1 8WYW HIS A 292 ? UNP P43405 ? ? 'expression tag' 644 12 
1 8WYW HIS A 293 ? UNP P43405 ? ? 'expression tag' 645 13 
2 8WYW MET B 1   ? UNP P43405 ? ? 'expression tag' 353 14 
2 8WYW ALA B 2   ? UNP P43405 ? ? 'expression tag' 354 15 
2 8WYW LEU B 3   ? UNP P43405 ? ? 'expression tag' 355 16 
2 8WYW LEU B 284 ? UNP P43405 ? ? 'expression tag' 636 17 
2 8WYW GLU B 285 ? UNP P43405 ? ? 'expression tag' 637 18 
2 8WYW HIS B 286 ? UNP P43405 ? ? 'expression tag' 638 19 
2 8WYW HIS B 287 ? UNP P43405 ? ? 'expression tag' 639 20 
2 8WYW HIS B 288 ? UNP P43405 ? ? 'expression tag' 640 21 
2 8WYW HIS B 289 ? UNP P43405 ? ? 'expression tag' 641 22 
2 8WYW HIS B 290 ? UNP P43405 ? ? 'expression tag' 642 23 
2 8WYW HIS B 291 ? UNP P43405 ? ? 'expression tag' 643 24 
2 8WYW HIS B 292 ? UNP P43405 ? ? 'expression tag' 644 25 
2 8WYW HIS B 293 ? UNP P43405 ? ? 'expression tag' 645 26 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 14  ? LYS A 16  ? ASP A 366 LYS A 368 5 ? 3  
HELX_P HELX_P2  AA2 ASN A 54  ? ASN A 57  ? ASN A 406 ASN A 409 5 ? 4  
HELX_P HELX_P3  AA3 ASP A 58  ? GLN A 73  ? ASP A 410 GLN A 425 1 ? 16 
HELX_P HELX_P4  AA4 LEU A 104 ? GLN A 110 ? LEU A 456 GLN A 462 1 ? 7  
HELX_P HELX_P5  AA5 LYS A 115 ? SER A 136 ? LYS A 467 SER A 488 1 ? 22 
HELX_P HELX_P6  AA6 ALA A 144 ? ARG A 146 ? ALA A 496 ARG A 498 5 ? 3  
HELX_P HELX_P7  AA7 PRO A 183 ? TYR A 187 ? PRO A 535 TYR A 539 5 ? 5  
HELX_P HELX_P8  AA8 ALA A 188 ? TYR A 195 ? ALA A 540 TYR A 547 1 ? 8  
HELX_P HELX_P9  AA9 SER A 199 ? SER A 215 ? SER A 551 SER A 567 1 ? 17 
HELX_P HELX_P10 AB1 LYS A 225 ? LYS A 235 ? LYS A 577 LYS A 587 1 ? 11 
HELX_P HELX_P11 AB2 PRO A 246 ? TRP A 257 ? PRO A 598 TRP A 609 1 ? 12 
HELX_P HELX_P12 AB3 GLY A 266 ? VAL A 281 ? GLY A 618 VAL A 633 1 ? 16 
HELX_P HELX_P13 AB4 ASP B 14  ? LYS B 16  ? ASP B 366 LYS B 368 5 ? 3  
HELX_P HELX_P14 AB5 ASN B 54  ? ASN B 57  ? ASN B 406 ASN B 409 5 ? 4  
HELX_P HELX_P15 AB6 ASP B 58  ? GLN B 73  ? ASP B 410 GLN B 425 1 ? 16 
HELX_P HELX_P16 AB7 LEU B 104 ? GLN B 110 ? LEU B 456 GLN B 462 1 ? 7  
HELX_P HELX_P17 AB8 LYS B 115 ? SER B 136 ? LYS B 467 SER B 488 1 ? 22 
HELX_P HELX_P18 AB9 ALA B 144 ? ARG B 146 ? ALA B 496 ARG B 498 5 ? 3  
HELX_P HELX_P19 AC1 PRO B 183 ? TYR B 187 ? PRO B 535 TYR B 539 5 ? 5  
HELX_P HELX_P20 AC2 ALA B 188 ? TYR B 195 ? ALA B 540 TYR B 547 1 ? 8  
HELX_P HELX_P21 AC3 SER B 199 ? SER B 215 ? SER B 551 SER B 567 1 ? 17 
HELX_P HELX_P22 AC4 LYS B 225 ? LYS B 235 ? LYS B 577 LYS B 587 1 ? 11 
HELX_P HELX_P23 AC5 PRO B 246 ? TRP B 257 ? PRO B 598 TRP B 609 1 ? 12 
HELX_P HELX_P24 AC6 GLY B 266 ? ASP B 280 ? GLY B 618 ASP B 632 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 4 ? 
AA7 ? 5 ? 
AA8 ? 3 ? 
AA9 ? 2 ? 
AB1 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AB1 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 18  ? LEU A 20  ? LEU A 370 LEU A 372 
AA1 2 GLY A 31  ? GLN A 39  ? GLY A 383 GLN A 391 
AA1 3 GLY A 26  ? GLY A 28  ? GLY A 378 GLY A 380 
AA2 1 LEU A 18  ? LEU A 20  ? LEU A 370 LEU A 372 
AA2 2 GLY A 31  ? GLN A 39  ? GLY A 383 GLN A 391 
AA2 3 VAL A 44  ? LEU A 52  ? VAL A 396 LEU A 404 
AA2 4 TRP A 92  ? GLU A 97  ? TRP A 444 GLU A 449 
AA2 5 MET A 83  ? GLU A 88  ? MET A 435 GLU A 440 
AA3 1 GLY A 102 ? PRO A 103 ? GLY A 454 PRO A 455 
AA3 2 VAL A 148 ? THR A 152 ? VAL A 500 THR A 504 
AA3 3 TYR A 155 ? ILE A 158 ? TYR A 507 ILE A 510 
AA4 1 PHE A 138 ? VAL A 139 ? PHE A 490 VAL A 491 
AA4 2 LYS A 165 ? ALA A 166 ? LYS A 517 ALA A 518 
AA5 1 TYR A 173 ? LYS A 175 ? TYR A 525 LYS A 527 
AA5 2 LYS A 196 ? SER A 198 ? LYS A 548 SER A 550 
AA6 1 GLU A 237 ? ARG A 238 ? GLU A 589 ARG A 590 
AA6 2 VAL B 44  ? LEU B 52  ? VAL B 396 LEU B 404 
AA6 3 GLY B 31  ? GLN B 39  ? GLY B 383 GLN B 391 
AA6 4 GLY B 26  ? GLY B 28  ? GLY B 378 GLY B 380 
AA7 1 LEU B 18  ? LEU B 20  ? LEU B 370 LEU B 372 
AA7 2 GLY B 31  ? GLN B 39  ? GLY B 383 GLN B 391 
AA7 3 VAL B 44  ? LEU B 52  ? VAL B 396 LEU B 404 
AA7 4 TRP B 92  ? GLU B 97  ? TRP B 444 GLU B 449 
AA7 5 MET B 83  ? GLU B 88  ? MET B 435 GLU B 440 
AA8 1 GLY B 102 ? PRO B 103 ? GLY B 454 PRO B 455 
AA8 2 VAL B 148 ? THR B 152 ? VAL B 500 THR B 504 
AA8 3 TYR B 155 ? ILE B 158 ? TYR B 507 ILE B 510 
AA9 1 PHE B 138 ? VAL B 139 ? PHE B 490 VAL B 491 
AA9 2 LYS B 165 ? ALA B 166 ? LYS B 517 ALA B 518 
AB1 1 TYR B 173 ? LYS B 175 ? TYR B 525 LYS B 527 
AB1 2 LYS B 196 ? SER B 198 ? LYS B 548 SER B 550 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N THR A 19  ? N THR A 371 O TYR A 37  ? O TYR A 389 
AA1 2 3 O GLY A 31  ? O GLY A 383 N GLY A 28  ? N GLY A 380 
AA2 1 2 N THR A 19  ? N THR A 371 O TYR A 37  ? O TYR A 389 
AA2 2 3 N THR A 32  ? N THR A 384 O ILE A 51  ? O ILE A 403 
AA2 3 4 N ALA A 48  ? N ALA A 400 O MET A 96  ? O MET A 448 
AA2 4 5 O VAL A 95  ? O VAL A 447 N GLY A 85  ? N GLY A 437 
AA3 1 2 N GLY A 102 ? N GLY A 454 O LEU A 150 ? O LEU A 502 
AA3 2 3 N LEU A 149 ? N LEU A 501 O LYS A 157 ? O LYS A 509 
AA4 1 2 N VAL A 139 ? N VAL A 491 O LYS A 165 ? O LYS A 517 
AA5 1 2 N TYR A 174 ? N TYR A 526 O PHE A 197 ? O PHE A 549 
AA6 1 2 N ARG A 238 ? N ARG A 590 O VAL B 44  ? O VAL B 396 
AA6 2 3 O ILE B 51  ? O ILE B 403 N THR B 32  ? N THR B 384 
AA6 3 4 O VAL B 33  ? O VAL B 385 N GLY B 26  ? N GLY B 378 
AA7 1 2 N THR B 19  ? N THR B 371 O TYR B 37  ? O TYR B 389 
AA7 2 3 N THR B 32  ? N THR B 384 O ILE B 51  ? O ILE B 403 
AA7 3 4 N ALA B 48  ? N ALA B 400 O MET B 96  ? O MET B 448 
AA7 4 5 O VAL B 95  ? O VAL B 447 N GLY B 85  ? N GLY B 437 
AA8 1 2 N GLY B 102 ? N GLY B 454 O LEU B 150 ? O LEU B 502 
AA8 2 3 N LEU B 149 ? N LEU B 501 O LYS B 157 ? O LYS B 509 
AA9 1 2 N VAL B 139 ? N VAL B 491 O LYS B 165 ? O LYS B 517 
AB1 1 2 N TYR B 174 ? N TYR B 526 O PHE B 197 ? O PHE B 549 
# 
_pdbx_entry_details.entry_id                   8WYW 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS A 393 ? ? 46.20   -75.49  
2  1 LYS A 394 ? ? -122.70 -53.29  
3  1 ALA A 441 ? ? -174.90 119.16  
4  1 GLU A 442 ? ? 65.91   -32.28  
5  1 ASP A 494 ? ? -149.34 47.01   
6  1 ASP A 512 ? ? 66.23   68.08   
7  1 TRP A 609 ? ? -88.75  36.81   
8  1 MET B 392 ? ? -97.79  -157.00 
9  1 LYS B 394 ? ? -138.84 -45.60  
10 1 ALA B 441 ? ? -135.09 -123.89 
11 1 ASP B 494 ? ? -148.42 47.39   
12 1 ASP B 512 ? ? 64.92   68.41   
13 1 TRP B 609 ? ? -86.63  31.73   
# 
_space_group_symop.id              1 
_space_group_symop.operation_xyz   x,y,z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 353 ? A MET 1   
2  1 Y 1 A ALA 354 ? A ALA 2   
3  1 Y 1 A LEU 355 ? A LEU 3   
4  1 Y 1 A GLU 356 ? A GLU 4   
5  1 Y 1 A GLU 357 ? A GLU 5   
6  1 Y 1 A ILE 358 ? A ILE 6   
7  1 Y 1 A ARG 359 ? A ARG 7   
8  1 Y 1 A PRO 360 ? A PRO 8   
9  1 Y 1 A LYS 361 ? A LYS 9   
10 1 Y 1 A GLU 362 ? A GLU 10  
11 1 Y 1 A VAL 363 ? A VAL 11  
12 1 Y 1 A GLN 529 ? A GLN 177 
13 1 Y 1 A THR 530 ? A THR 178 
14 1 Y 1 A HIS 531 ? A HIS 179 
15 1 Y 1 A GLY 532 ? A GLY 180 
16 1 Y 1 A LYS 533 ? A LYS 181 
17 1 Y 1 A TRP 534 ? A TRP 182 
18 1 Y 1 A VAL 634 ? A VAL 282 
19 1 Y 1 A ASN 635 ? A ASN 283 
20 1 Y 1 A LEU 636 ? A LEU 284 
21 1 Y 1 A GLU 637 ? A GLU 285 
22 1 Y 1 A HIS 638 ? A HIS 286 
23 1 Y 1 A HIS 639 ? A HIS 287 
24 1 Y 1 A HIS 640 ? A HIS 288 
25 1 Y 1 A HIS 641 ? A HIS 289 
26 1 Y 1 A HIS 642 ? A HIS 290 
27 1 Y 1 A HIS 643 ? A HIS 291 
28 1 Y 1 A HIS 644 ? A HIS 292 
29 1 Y 1 A HIS 645 ? A HIS 293 
30 1 Y 1 B MET 353 ? B MET 1   
31 1 Y 1 B ALA 354 ? B ALA 2   
32 1 Y 1 B LEU 355 ? B LEU 3   
33 1 Y 1 B GLU 356 ? B GLU 4   
34 1 Y 1 B GLU 357 ? B GLU 5   
35 1 Y 1 B ILE 358 ? B ILE 6   
36 1 Y 1 B ARG 359 ? B ARG 7   
37 1 Y 1 B PRO 360 ? B PRO 8   
38 1 Y 1 B LYS 361 ? B LYS 9   
39 1 Y 1 B GLU 362 ? B GLU 10  
40 1 Y 1 B VAL 363 ? B VAL 11  
41 1 Y 1 B TYR 364 ? B TYR 12  
42 1 Y 1 B GLN 529 ? B GLN 177 
43 1 Y 1 B THR 530 ? B THR 178 
44 1 Y 1 B HIS 531 ? B HIS 179 
45 1 Y 1 B GLY 532 ? B GLY 180 
46 1 Y 1 B LYS 533 ? B LYS 181 
47 1 Y 1 B TRP 534 ? B TRP 182 
48 1 Y 1 B VAL 634 ? B VAL 282 
49 1 Y 1 B ASN 635 ? B ASN 283 
50 1 Y 1 B LEU 636 ? B LEU 284 
51 1 Y 1 B GLU 637 ? B GLU 285 
52 1 Y 1 B HIS 638 ? B HIS 286 
53 1 Y 1 B HIS 639 ? B HIS 287 
54 1 Y 1 B HIS 640 ? B HIS 288 
55 1 Y 1 B HIS 641 ? B HIS 289 
56 1 Y 1 B HIS 642 ? B HIS 290 
57 1 Y 1 B HIS 643 ? B HIS 291 
58 1 Y 1 B HIS 644 ? B HIS 292 
59 1 Y 1 B HIS 645 ? B HIS 293 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
GOL C1   C N N 137 
GOL O1   O N N 138 
GOL C2   C N N 139 
GOL O2   O N N 140 
GOL C3   C N N 141 
GOL O3   O N N 142 
GOL H11  H N N 143 
GOL H12  H N N 144 
GOL HO1  H N N 145 
GOL H2   H N N 146 
GOL HO2  H N N 147 
GOL H31  H N N 148 
GOL H32  H N N 149 
GOL HO3  H N N 150 
HIS N    N N N 151 
HIS CA   C N S 152 
HIS C    C N N 153 
HIS O    O N N 154 
HIS CB   C N N 155 
HIS CG   C Y N 156 
HIS ND1  N Y N 157 
HIS CD2  C Y N 158 
HIS CE1  C Y N 159 
HIS NE2  N Y N 160 
HIS OXT  O N N 161 
HIS H    H N N 162 
HIS H2   H N N 163 
HIS HA   H N N 164 
HIS HB2  H N N 165 
HIS HB3  H N N 166 
HIS HD1  H N N 167 
HIS HD2  H N N 168 
HIS HE1  H N N 169 
HIS HE2  H N N 170 
HIS HXT  H N N 171 
HOH O    O N N 172 
HOH H1   H N N 173 
HOH H2   H N N 174 
ILE N    N N N 175 
ILE CA   C N S 176 
ILE C    C N N 177 
ILE O    O N N 178 
ILE CB   C N S 179 
ILE CG1  C N N 180 
ILE CG2  C N N 181 
ILE CD1  C N N 182 
ILE OXT  O N N 183 
ILE H    H N N 184 
ILE H2   H N N 185 
ILE HA   H N N 186 
ILE HB   H N N 187 
ILE HG12 H N N 188 
ILE HG13 H N N 189 
ILE HG21 H N N 190 
ILE HG22 H N N 191 
ILE HG23 H N N 192 
ILE HD11 H N N 193 
ILE HD12 H N N 194 
ILE HD13 H N N 195 
ILE HXT  H N N 196 
LEU N    N N N 197 
LEU CA   C N S 198 
LEU C    C N N 199 
LEU O    O N N 200 
LEU CB   C N N 201 
LEU CG   C N N 202 
LEU CD1  C N N 203 
LEU CD2  C N N 204 
LEU OXT  O N N 205 
LEU H    H N N 206 
LEU H2   H N N 207 
LEU HA   H N N 208 
LEU HB2  H N N 209 
LEU HB3  H N N 210 
LEU HG   H N N 211 
LEU HD11 H N N 212 
LEU HD12 H N N 213 
LEU HD13 H N N 214 
LEU HD21 H N N 215 
LEU HD22 H N N 216 
LEU HD23 H N N 217 
LEU HXT  H N N 218 
LYS N    N N N 219 
LYS CA   C N S 220 
LYS C    C N N 221 
LYS O    O N N 222 
LYS CB   C N N 223 
LYS CG   C N N 224 
LYS CD   C N N 225 
LYS CE   C N N 226 
LYS NZ   N N N 227 
LYS OXT  O N N 228 
LYS H    H N N 229 
LYS H2   H N N 230 
LYS HA   H N N 231 
LYS HB2  H N N 232 
LYS HB3  H N N 233 
LYS HG2  H N N 234 
LYS HG3  H N N 235 
LYS HD2  H N N 236 
LYS HD3  H N N 237 
LYS HE2  H N N 238 
LYS HE3  H N N 239 
LYS HZ1  H N N 240 
LYS HZ2  H N N 241 
LYS HZ3  H N N 242 
LYS HXT  H N N 243 
MET N    N N N 244 
MET CA   C N S 245 
MET C    C N N 246 
MET O    O N N 247 
MET CB   C N N 248 
MET CG   C N N 249 
MET SD   S N N 250 
MET CE   C N N 251 
MET OXT  O N N 252 
MET H    H N N 253 
MET H2   H N N 254 
MET HA   H N N 255 
MET HB2  H N N 256 
MET HB3  H N N 257 
MET HG2  H N N 258 
MET HG3  H N N 259 
MET HE1  H N N 260 
MET HE2  H N N 261 
MET HE3  H N N 262 
MET HXT  H N N 263 
PHE N    N N N 264 
PHE CA   C N S 265 
PHE C    C N N 266 
PHE O    O N N 267 
PHE CB   C N N 268 
PHE CG   C Y N 269 
PHE CD1  C Y N 270 
PHE CD2  C Y N 271 
PHE CE1  C Y N 272 
PHE CE2  C Y N 273 
PHE CZ   C Y N 274 
PHE OXT  O N N 275 
PHE H    H N N 276 
PHE H2   H N N 277 
PHE HA   H N N 278 
PHE HB2  H N N 279 
PHE HB3  H N N 280 
PHE HD1  H N N 281 
PHE HD2  H N N 282 
PHE HE1  H N N 283 
PHE HE2  H N N 284 
PHE HZ   H N N 285 
PHE HXT  H N N 286 
PRO N    N N N 287 
PRO CA   C N S 288 
PRO C    C N N 289 
PRO O    O N N 290 
PRO CB   C N N 291 
PRO CG   C N N 292 
PRO CD   C N N 293 
PRO OXT  O N N 294 
PRO H    H N N 295 
PRO HA   H N N 296 
PRO HB2  H N N 297 
PRO HB3  H N N 298 
PRO HG2  H N N 299 
PRO HG3  H N N 300 
PRO HD2  H N N 301 
PRO HD3  H N N 302 
PRO HXT  H N N 303 
SER N    N N N 304 
SER CA   C N S 305 
SER C    C N N 306 
SER O    O N N 307 
SER CB   C N N 308 
SER OG   O N N 309 
SER OXT  O N N 310 
SER H    H N N 311 
SER H2   H N N 312 
SER HA   H N N 313 
SER HB2  H N N 314 
SER HB3  H N N 315 
SER HG   H N N 316 
SER HXT  H N N 317 
THR N    N N N 318 
THR CA   C N S 319 
THR C    C N N 320 
THR O    O N N 321 
THR CB   C N R 322 
THR OG1  O N N 323 
THR CG2  C N N 324 
THR OXT  O N N 325 
THR H    H N N 326 
THR H2   H N N 327 
THR HA   H N N 328 
THR HB   H N N 329 
THR HG1  H N N 330 
THR HG21 H N N 331 
THR HG22 H N N 332 
THR HG23 H N N 333 
THR HXT  H N N 334 
TRP N    N N N 335 
TRP CA   C N S 336 
TRP C    C N N 337 
TRP O    O N N 338 
TRP CB   C N N 339 
TRP CG   C Y N 340 
TRP CD1  C Y N 341 
TRP CD2  C Y N 342 
TRP NE1  N Y N 343 
TRP CE2  C Y N 344 
TRP CE3  C Y N 345 
TRP CZ2  C Y N 346 
TRP CZ3  C Y N 347 
TRP CH2  C Y N 348 
TRP OXT  O N N 349 
TRP H    H N N 350 
TRP H2   H N N 351 
TRP HA   H N N 352 
TRP HB2  H N N 353 
TRP HB3  H N N 354 
TRP HD1  H N N 355 
TRP HE1  H N N 356 
TRP HE3  H N N 357 
TRP HZ2  H N N 358 
TRP HZ3  H N N 359 
TRP HH2  H N N 360 
TRP HXT  H N N 361 
TYR N    N N N 362 
TYR CA   C N S 363 
TYR C    C N N 364 
TYR O    O N N 365 
TYR CB   C N N 366 
TYR CG   C Y N 367 
TYR CD1  C Y N 368 
TYR CD2  C Y N 369 
TYR CE1  C Y N 370 
TYR CE2  C Y N 371 
TYR CZ   C Y N 372 
TYR OH   O N N 373 
TYR OXT  O N N 374 
TYR H    H N N 375 
TYR H2   H N N 376 
TYR HA   H N N 377 
TYR HB2  H N N 378 
TYR HB3  H N N 379 
TYR HD1  H N N 380 
TYR HD2  H N N 381 
TYR HE1  H N N 382 
TYR HE2  H N N 383 
TYR HH   H N N 384 
TYR HXT  H N N 385 
VAL N    N N N 386 
VAL CA   C N S 387 
VAL C    C N N 388 
VAL O    O N N 389 
VAL CB   C N N 390 
VAL CG1  C N N 391 
VAL CG2  C N N 392 
VAL OXT  O N N 393 
VAL H    H N N 394 
VAL H2   H N N 395 
VAL HA   H N N 396 
VAL HB   H N N 397 
VAL HG11 H N N 398 
VAL HG12 H N N 399 
VAL HG13 H N N 400 
VAL HG21 H N N 401 
VAL HG22 H N N 402 
VAL HG23 H N N 403 
VAL HXT  H N N 404 
XFB C1   C Y N 405 
XFB C10  C N N 406 
XFB C11  C N N 407 
XFB C12  C N N 408 
XFB C13  C N N 409 
XFB C14  C Y N 410 
XFB C15  C Y N 411 
XFB C16  C Y N 412 
XFB C17  C Y N 413 
XFB C18  C Y N 414 
XFB C19  C Y N 415 
XFB C2   C Y N 416 
XFB C20  C Y N 417 
XFB C21  C N N 418 
XFB C22  C N N 419 
XFB C23  C N N 420 
XFB C24  C N S 421 
XFB C25  C N N 422 
XFB C3   C Y N 423 
XFB C4   C Y N 424 
XFB C5   C Y N 425 
XFB C6   C Y N 426 
XFB C7   C Y N 427 
XFB C8   C Y N 428 
XFB C9   C N N 429 
XFB N1   N Y N 430 
XFB N2   N N N 431 
XFB N3   N Y N 432 
XFB N4   N Y N 433 
XFB N5   N Y N 434 
XFB N6   N Y N 435 
XFB N7   N N N 436 
XFB O1   O N N 437 
XFB O2   O N N 438 
XFB O3   O N N 439 
XFB H1   H N N 440 
XFB H2   H N N 441 
XFB H3   H N N 442 
XFB H4   H N N 443 
XFB H5   H N N 444 
XFB H6   H N N 445 
XFB H7   H N N 446 
XFB H8   H N N 447 
XFB H9   H N N 448 
XFB H10  H N N 449 
XFB H11  H N N 450 
XFB H12  H N N 451 
XFB H13  H N N 452 
XFB H14  H N N 453 
XFB H15  H N N 454 
XFB H16  H N N 455 
XFB H17  H N N 456 
XFB H18  H N N 457 
XFB H19  H N N 458 
XFB H20  H N N 459 
XFB H21  H N N 460 
XFB H22  H N N 461 
XFB H23  H N N 462 
XFB H24  H N N 463 
XFB H25  H N N 464 
XFB H26  H N N 465 
XFB H27  H N N 466 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
XFB C23 C24  sing N N 389 
XFB C23 O2   sing N N 390 
XFB C24 O3   sing N N 391 
XFB C24 C25  sing N N 392 
XFB O2  N7   sing N N 393 
XFB C25 N7   sing N N 394 
XFB C21 C20  sing N N 395 
XFB N7  C22  sing N N 396 
XFB C22 C19  sing N N 397 
XFB C20 C19  sing Y N 398 
XFB C20 N6   doub Y N 399 
XFB C19 C18  doub Y N 400 
XFB C11 C12  sing N N 401 
XFB C11 C10  sing N N 402 
XFB N6  N5   sing Y N 403 
XFB C18 N5   sing Y N 404 
XFB C12 C10  sing N N 405 
XFB N5  C15  sing N N 406 
XFB C10 C9   sing N N 407 
XFB O1  C9   doub N N 408 
XFB C9  C8   sing N N 409 
XFB C15 C16  doub Y N 410 
XFB C15 N3   sing Y N 411 
XFB C16 C17  sing Y N 412 
XFB N3  C14  doub Y N 413 
XFB C8  C7   doub Y N 414 
XFB C8  C6   sing Y N 415 
XFB C17 N4   doub Y N 416 
XFB C7  N1   sing Y N 417 
XFB C5  C6   doub Y N 418 
XFB C5  C4   sing Y N 419 
XFB C6  C1   sing Y N 420 
XFB C14 N4   sing Y N 421 
XFB C14 N2   sing N N 422 
XFB N1  C1   sing Y N 423 
XFB N1  C13  sing N N 424 
XFB C4  N2   sing N N 425 
XFB C4  C3   doub Y N 426 
XFB C1  C2   doub Y N 427 
XFB C2  C3   sing Y N 428 
XFB C10 H1   sing N N 429 
XFB C11 H2   sing N N 430 
XFB C11 H3   sing N N 431 
XFB C12 H4   sing N N 432 
XFB C12 H5   sing N N 433 
XFB C13 H6   sing N N 434 
XFB C13 H7   sing N N 435 
XFB C13 H8   sing N N 436 
XFB C16 H9   sing N N 437 
XFB C17 H10  sing N N 438 
XFB C18 H11  sing N N 439 
XFB C2  H12  sing N N 440 
XFB C21 H13  sing N N 441 
XFB C21 H14  sing N N 442 
XFB C21 H15  sing N N 443 
XFB C22 H16  sing N N 444 
XFB C22 H17  sing N N 445 
XFB C23 H18  sing N N 446 
XFB C23 H19  sing N N 447 
XFB C24 H20  sing N N 448 
XFB C25 H21  sing N N 449 
XFB C25 H22  sing N N 450 
XFB C3  H23  sing N N 451 
XFB C5  H24  sing N N 452 
XFB C7  H25  sing N N 453 
XFB N2  H26  sing N N 454 
XFB O3  H27  sing N N 455 
# 
_pdbx_audit_support.funding_organization   'National Research Foundation (NRF, Korea)' 
_pdbx_audit_support.country                'Korea, Republic Of' 
_pdbx_audit_support.grant_number           2023R1A2C1002654 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4XG2 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1' 
_space_group.name_Hall        'P 1' 
_space_group.IT_number        1 
_space_group.crystal_system   triclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8WYW 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.025177 
_atom_sites.fract_transf_matrix[1][2]   0.002119 
_atom_sites.fract_transf_matrix[1][3]   0.000013 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.025341 
_atom_sites.fract_transf_matrix[2][3]   0.000016 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011318 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . TYR A 1 12  ? -11.96345 -22.45877 37.58711  1.000 64.00712 ? 364 TYR A N   1 
ATOM   2    C CA  . TYR A 1 12  ? -12.96132 -21.53934 38.13157  1.000 55.68330 ? 364 TYR A CA  1 
ATOM   3    C C   . TYR A 1 12  ? -12.59852 -21.12616 39.54680  1.000 52.91770 ? 364 TYR A C   1 
ATOM   4    O O   . TYR A 1 12  ? -12.19321 -21.95145 40.36336  1.000 50.12604 ? 364 TYR A O   1 
ATOM   5    C CB  . TYR A 1 12  ? -14.35203 -22.17199 38.07804  1.000 52.04638 ? 364 TYR A CB  1 
ATOM   6    C CG  . TYR A 1 12  ? -14.82529 -22.31379 36.65667  1.000 61.05642 ? 364 TYR A CG  1 
ATOM   7    C CD1 . TYR A 1 12  ? -14.43558 -23.39787 35.88140  1.000 66.68883 ? 364 TYR A CD1 1 
ATOM   8    C CD2 . TYR A 1 12  ? -15.62088 -21.33746 36.06970  1.000 59.37148 ? 364 TYR A CD2 1 
ATOM   9    C CE1 . TYR A 1 12  ? -14.84394 -23.51776 34.56866  1.000 73.49904 ? 364 TYR A CE1 1 
ATOM   10   C CE2 . TYR A 1 12  ? -16.03401 -21.45008 34.75813  1.000 57.95694 ? 364 TYR A CE2 1 
ATOM   11   C CZ  . TYR A 1 12  ? -15.64209 -22.54114 34.01246  1.000 60.90827 ? 364 TYR A CZ  1 
ATOM   12   O OH  . TYR A 1 12  ? -16.04908 -22.66033 32.70532  1.000 69.67254 ? 364 TYR A OH  1 
ATOM   13   N N   . LEU A 1 13  ? -12.72778 -19.83599 39.83124  1.000 46.16901 ? 365 LEU A N   1 
ATOM   14   C CA  . LEU A 1 13  ? -12.27278 -19.31453 41.10800  1.000 44.47333 ? 365 LEU A CA  1 
ATOM   15   C C   . LEU A 1 13  ? -13.40252 -19.29880 42.13756  1.000 44.92830 ? 365 LEU A C   1 
ATOM   16   O O   . LEU A 1 13  ? -14.59152 -19.31893 41.80827  1.000 48.55479 ? 365 LEU A O   1 
ATOM   17   C CB  . LEU A 1 13  ? -11.68891 -17.91217 40.93806  1.000 43.64137 ? 365 LEU A CB  1 
ATOM   18   C CG  . LEU A 1 13  ? -10.49749 -17.82510 39.97849  1.000 45.36592 ? 365 LEU A CG  1 
ATOM   19   C CD1 . LEU A 1 13  ? -9.94183  -16.41437 39.92595  1.000 44.68426 ? 365 LEU A CD1 1 
ATOM   20   C CD2 . LEU A 1 13  ? -9.41566  -18.80654 40.38081  1.000 34.97432 ? 365 LEU A CD2 1 
ATOM   21   N N   . ASP A 1 14  ? -13.00157 -19.24945 43.40157  1.000 38.57228 ? 366 ASP A N   1 
ATOM   22   C CA  . ASP A 1 14  ? -13.91761 -19.25216 44.53534  1.000 41.11165 ? 366 ASP A CA  1 
ATOM   23   C C   . ASP A 1 14  ? -14.24713 -17.80540 44.89494  1.000 41.17635 ? 366 ASP A C   1 
ATOM   24   O O   . ASP A 1 14  ? -13.38318 -17.06967 45.38283  1.000 40.36647 ? 366 ASP A O   1 
ATOM   25   C CB  . ASP A 1 14  ? -13.26697 -19.99620 45.70122  1.000 45.38730 ? 366 ASP A CB  1 
ATOM   26   C CG  . ASP A 1 14  ? -14.19121 -20.17583 46.89320  1.000 54.59612 ? 366 ASP A CG  1 
ATOM   27   O OD1 . ASP A 1 14  ? -15.32794 -19.65236 46.88011  1.000 51.13484 ? 366 ASP A OD1 1 
ATOM   28   O OD2 . ASP A 1 14  ? -13.76057 -20.85266 47.85288  1.000 54.50725 ? 366 ASP A OD2 1 
ATOM   29   N N   . ARG A 1 15  ? -15.49854 -17.39595 44.65843  1.000 32.89334 ? 367 ARG A N   1 
ATOM   30   C CA  . ARG A 1 15  ? -15.90855 -16.02519 44.97518  1.000 40.03860 ? 367 ARG A CA  1 
ATOM   31   C C   . ARG A 1 15  ? -15.60121 -15.65954 46.42872  1.000 44.85495 ? 367 ARG A C   1 
ATOM   32   O O   . ARG A 1 15  ? -15.41875 -14.47881 46.75465  1.000 35.55671 ? 367 ARG A O   1 
ATOM   33   C CB  . ARG A 1 15  ? -17.40687 -15.84754 44.67657  1.000 36.35408 ? 367 ARG A CB  1 
ATOM   34   C CG  . ARG A 1 15  ? -17.94691 -14.44030 44.93064  1.000 41.39997 ? 367 ARG A CG  1 
ATOM   35   C CD  . ARG A 1 15  ? -17.27494 -13.42896 44.01413  1.000 36.97143 ? 367 ARG A CD  1 
ATOM   36   N NE  . ARG A 1 15  ? -17.83867 -12.09324 44.15467  1.000 39.09971 ? 367 ARG A NE  1 
ATOM   37   C CZ  . ARG A 1 15  ? -17.36772 -11.16992 44.98141  1.000 39.87015 ? 367 ARG A CZ  1 
ATOM   38   N NH1 . ARG A 1 15  ? -16.33471 -11.41241 45.77159  1.000 44.70277 ? 367 ARG A NH1 1 
ATOM   39   N NH2 . ARG A 1 15  ? -17.93891 -9.97203  45.00834  1.000 37.06955 ? 367 ARG A NH2 1 
ATOM   40   N N   . LYS A 1 16  ? -15.50741 -16.66010 47.30844  1.000 40.50052 ? 368 LYS A N   1 
ATOM   41   C CA  . LYS A 1 16  ? -15.22601 -16.38618 48.70917  1.000 48.61546 ? 368 LYS A CA  1 
ATOM   42   C C   . LYS A 1 16  ? -13.78732 -15.92860 48.92240  1.000 41.66466 ? 368 LYS A C   1 
ATOM   43   O O   . LYS A 1 16  ? -13.50570 -15.22430 49.89809  1.000 43.12430 ? 368 LYS A O   1 
ATOM   44   C CB  . LYS A 1 16  ? -15.52584 -17.62546 49.54885  1.000 48.97670 ? 368 LYS A CB  1 
ATOM   45   C CG  . LYS A 1 16  ? -16.96264 -17.70324 50.05753  1.000 56.27237 ? 368 LYS A CG  1 
ATOM   46   C CD  . LYS A 1 16  ? -17.17787 -16.76314 51.24114  1.000 61.98904 ? 368 LYS A CD  1 
ATOM   47   C CE  . LYS A 1 16  ? -17.87766 -15.47113 50.83787  1.000 61.95916 ? 368 LYS A CE  1 
ATOM   48   N NZ  . LYS A 1 16  ? -17.75881 -14.43195 51.90605  1.000 65.26929 ? 368 LYS A NZ  1 
ATOM   49   N N   . LEU A 1 17  ? -12.87257 -16.32333 48.03927  1.000 41.14503 ? 369 LEU A N   1 
ATOM   50   C CA  . LEU A 1 17  ? -11.46709 -15.95531 48.14541  1.000 39.41814 ? 369 LEU A CA  1 
ATOM   51   C C   . LEU A 1 17  ? -11.15595 -14.63972 47.44900  1.000 41.91173 ? 369 LEU A C   1 
ATOM   52   O O   . LEU A 1 17  ? -9.98070  -14.25438 47.36228  1.000 35.03730 ? 369 LEU A O   1 
ATOM   53   C CB  . LEU A 1 17  ? -10.58432 -17.07049 47.57090  1.000 39.76738 ? 369 LEU A CB  1 
ATOM   54   C CG  . LEU A 1 17  ? -10.75803 -18.43437 48.24897  1.000 46.76185 ? 369 LEU A CG  1 
ATOM   55   C CD1 . LEU A 1 17  ? -9.72696  -19.45010 47.74592  1.000 38.90526 ? 369 LEU A CD1 1 
ATOM   56   C CD2 . LEU A 1 17  ? -10.70045 -18.27643 49.76723  1.000 46.75690 ? 369 LEU A CD2 1 
ATOM   57   N N   . LEU A 1 18  ? -12.17658 -13.94010 46.96763  1.000 33.86463 ? 370 LEU A N   1 
ATOM   58   C CA  . LEU A 1 18  ? -11.99782 -12.72770 46.19029  1.000 31.96043 ? 370 LEU A CA  1 
ATOM   59   C C   . LEU A 1 18  ? -12.69298 -11.56995 46.87408  1.000 35.61441 ? 370 LEU A C   1 
ATOM   60   O O   . LEU A 1 18  ? -13.89187 -11.64792 47.17568  1.000 39.49227 ? 370 LEU A O   1 
ATOM   61   C CB  . LEU A 1 18  ? -12.56262 -12.89267 44.78543  1.000 34.43662 ? 370 LEU A CB  1 
ATOM   62   C CG  . LEU A 1 18  ? -12.40287 -11.59562 43.99437  1.000 35.46466 ? 370 LEU A CG  1 
ATOM   63   C CD1 . LEU A 1 18  ? -10.94401 -11.42256 43.51190  1.000 26.92600 ? 370 LEU A CD1 1 
ATOM   64   C CD2 . LEU A 1 18  ? -13.34437 -11.61043 42.84161  1.000 33.97427 ? 370 LEU A CD2 1 
ATOM   65   N N   . THR A 1 19  ? -11.94839 -10.49992 47.10388  1.000 29.27134 ? 371 THR A N   1 
ATOM   66   C CA  . THR A 1 19  ? -12.49204 -9.25101  47.60975  1.000 29.54135 ? 371 THR A CA  1 
ATOM   67   C C   . THR A 1 19  ? -12.41540 -8.22260  46.49708  1.000 37.15922 ? 371 THR A C   1 
ATOM   68   O O   . THR A 1 19  ? -11.37658 -8.09956  45.83936  1.000 36.28668 ? 371 THR A O   1 
ATOM   69   C CB  . THR A 1 19  ? -11.71903 -8.75565  48.83508  1.000 33.71349 ? 371 THR A CB  1 
ATOM   70   O OG1 . THR A 1 19  ? -11.99259 -9.60241  49.95298  1.000 39.43298 ? 371 THR A OG1 1 
ATOM   71   C CG2 . THR A 1 19  ? -12.11417 -7.32168  49.18346  1.000 28.81056 ? 371 THR A CG2 1 
ATOM   72   N N   . LEU A 1 20  ? -13.51090 -7.50410  46.27246  1.000 29.65399 ? 372 LEU A N   1 
ATOM   73   C CA  . LEU A 1 20  ? -13.55034 -6.44981  45.27027  1.000 28.02099 ? 372 LEU A CA  1 
ATOM   74   C C   . LEU A 1 20  ? -13.71317 -5.09130  45.94156  1.000 35.09733 ? 372 LEU A C   1 
ATOM   75   O O   . LEU A 1 20  ? -14.51393 -4.93725  46.86711  1.000 35.17451 ? 372 LEU A O   1 
ATOM   76   C CB  . LEU A 1 20  ? -14.69183 -6.67707  44.27248  1.000 26.94511 ? 372 LEU A CB  1 
ATOM   77   C CG  . LEU A 1 20  ? -14.59128 -7.86442  43.30669  1.000 34.71971 ? 372 LEU A CG  1 
ATOM   78   C CD1 . LEU A 1 20  ? -15.91281 -8.06993  42.56332  1.000 38.28675 ? 372 LEU A CD1 1 
ATOM   79   C CD2 . LEU A 1 20  ? -13.46578 -7.63805  42.31568  1.000 33.01795 ? 372 LEU A CD2 1 
ATOM   80   N N   . GLU A 1 21  ? -12.95423 -4.10498  45.46908  1.000 31.88969 ? 373 GLU A N   1 
ATOM   81   C CA  . GLU A 1 21  ? -13.15825 -2.72386  45.88688  1.000 37.81517 ? 373 GLU A CA  1 
ATOM   82   C C   . GLU A 1 21  ? -14.38398 -2.14724  45.19413  1.000 39.34679 ? 373 GLU A C   1 
ATOM   83   O O   . GLU A 1 21  ? -14.58565 -2.34758  43.99483  1.000 41.28395 ? 373 GLU A O   1 
ATOM   84   C CB  . GLU A 1 21  ? -11.92572 -1.87265  45.56545  1.000 36.84337 ? 373 GLU A CB  1 
ATOM   85   C CG  . GLU A 1 21  ? -10.71059 -2.17189  46.46357  1.000 37.99607 ? 373 GLU A CG  1 
ATOM   86   C CD  . GLU A 1 21  ? -10.93501 -1.73928  47.91987  1.000 58.32205 ? 373 GLU A CD  1 
ATOM   87   O OE1 . GLU A 1 21  ? -11.81078 -0.86897  48.15856  1.000 49.66971 ? 373 GLU A OE1 1 
ATOM   88   O OE2 . GLU A 1 21  ? -10.24044 -2.26998  48.82457  1.000 43.86655 ? 373 GLU A OE2 1 
ATOM   89   N N   . ASP A 1 22  ? -15.20164 -1.41741  45.95536  1.000 45.47716 ? 374 ASP A N   1 
ATOM   90   C CA  . ASP A 1 22  ? -16.47461 -0.93486  45.42012  1.000 50.82706 ? 374 ASP A CA  1 
ATOM   91   C C   . ASP A 1 22  ? -16.27237 0.04679   44.26726  1.000 49.27150 ? 374 ASP A C   1 
ATOM   92   O O   . ASP A 1 22  ? -16.96005 -0.04236  43.24102  1.000 46.76565 ? 374 ASP A O   1 
ATOM   93   C CB  . ASP A 1 22  ? -17.29543 -0.28702  46.53517  1.000 51.86918 ? 374 ASP A CB  1 
ATOM   94   C CG  . ASP A 1 22  ? -18.19904 -1.27079  47.23748  1.000 62.86836 ? 374 ASP A CG  1 
ATOM   95   O OD1 . ASP A 1 22  ? -19.12697 -1.79888  46.58608  1.000 74.57825 ? 374 ASP A OD1 1 
ATOM   96   O OD2 . ASP A 1 22  ? -17.98067 -1.51951  48.43904  1.000 70.22706 ? 374 ASP A OD2 1 
ATOM   97   N N   . LYS A 1 23  ? -15.34149 0.99212   44.41529  1.000 37.71796 ? 375 LYS A N   1 
ATOM   98   C CA  . LYS A 1 23  ? -15.11201 1.98752   43.37114  1.000 48.10302 ? 375 LYS A CA  1 
ATOM   99   C C   . LYS A 1 23  ? -14.40125 1.35280   42.18377  1.000 39.74190 ? 375 LYS A C   1 
ATOM   100  O O   . LYS A 1 23  ? -13.24008 0.94123   42.29182  1.000 44.42320 ? 375 LYS A O   1 
ATOM   101  C CB  . LYS A 1 23  ? -14.29159 3.16247   43.90279  1.000 51.63168 ? 375 LYS A CB  1 
ATOM   102  C CG  . LYS A 1 23  ? -13.92016 4.17483   42.80701  1.000 52.86871 ? 375 LYS A CG  1 
ATOM   103  C CD  . LYS A 1 23  ? -13.41922 5.49803   43.37971  1.000 62.86371 ? 375 LYS A CD  1 
ATOM   104  C CE  . LYS A 1 23  ? -14.56244 6.31536   43.99245  1.000 70.34298 ? 375 LYS A CE  1 
ATOM   105  N NZ  . LYS A 1 23  ? -15.25482 7.17954   42.98661  1.000 68.80036 ? 375 LYS A NZ  1 
ATOM   106  N N   . GLU A 1 24  ? -15.08637 1.31112   41.04682  1.000 41.77510 ? 376 GLU A N   1 
ATOM   107  C CA  . GLU A 1 24  ? -14.52226 0.73936   39.83319  1.000 38.20503 ? 376 GLU A CA  1 
ATOM   108  C C   . GLU A 1 24  ? -13.28093 1.50792   39.38768  1.000 37.66335 ? 376 GLU A C   1 
ATOM   109  O O   . GLU A 1 24  ? -13.13458 2.71024   39.63673  1.000 39.75373 ? 376 GLU A O   1 
ATOM   110  C CB  . GLU A 1 24  ? -15.56244 0.76855   38.71327  1.000 40.18308 ? 376 GLU A CB  1 
ATOM   111  C CG  . GLU A 1 24  ? -16.04196 2.18274   38.40894  1.000 53.34374 ? 376 GLU A CG  1 
ATOM   112  C CD  . GLU A 1 24  ? -16.89078 2.28363   37.15259  1.000 60.55062 ? 376 GLU A CD  1 
ATOM   113  O OE1 . GLU A 1 24  ? -17.97230 1.66044   37.11836  1.000 58.27273 ? 376 GLU A OE1 1 
ATOM   114  O OE2 . GLU A 1 24  ? -16.46838 2.99441   36.20301  1.000 64.28021 ? 376 GLU A OE2 1 
ATOM   115  N N   . LEU A 1 25  ? -12.38685 0.79881   38.70210  1.000 33.45130 ? 377 LEU A N   1 
ATOM   116  C CA  . LEU A 1 25  ? -11.25294 1.43516   38.04373  1.000 36.06373 ? 377 LEU A CA  1 
ATOM   117  C C   . LEU A 1 25  ? -11.66493 2.13140   36.75737  1.000 42.19314 ? 377 LEU A C   1 
ATOM   118  O O   . LEU A 1 25  ? -10.97282 3.04619   36.30740  1.000 36.33805 ? 377 LEU A O   1 
ATOM   119  C CB  . LEU A 1 25  ? -10.17745 0.39834   37.72598  1.000 34.35496 ? 377 LEU A CB  1 
ATOM   120  C CG  . LEU A 1 25  ? -9.42152  -0.17003  38.91459  1.000 36.84576 ? 377 LEU A CG  1 
ATOM   121  C CD1 . LEU A 1 25  ? -8.63374  -1.37098  38.48079  1.000 29.43936 ? 377 LEU A CD1 1 
ATOM   122  C CD2 . LEU A 1 25  ? -8.50208  0.89068   39.53779  1.000 36.78713 ? 377 LEU A CD2 1 
ATOM   123  N N   . GLY A 1 26  ? -12.77203 1.70683   36.16890  1.000 35.79918 ? 378 GLY A N   1 
ATOM   124  C CA  . GLY A 1 26  ? -13.24697 2.25501   34.92108  1.000 39.14452 ? 378 GLY A CA  1 
ATOM   125  C C   . GLY A 1 26  ? -14.36324 1.37420   34.41184  1.000 37.01870 ? 378 GLY A C   1 
ATOM   126  O O   . GLY A 1 26  ? -14.75233 0.39039   35.05116  1.000 38.33679 ? 378 GLY A O   1 
ATOM   127  N N   . SER A 1 27  ? -14.86436 1.73100   33.23617  1.000 40.78813 ? 379 SER A N   1 
ATOM   128  C CA  . SER A 1 27  ? -15.95036 0.97871   32.62933  1.000 43.07896 ? 379 SER A CA  1 
ATOM   129  C C   . SER A 1 27  ? -15.76485 0.94900   31.11842  1.000 46.50672 ? 379 SER A C   1 
ATOM   130  O O   . SER A 1 27  ? -14.98450 1.71721   30.54513  1.000 45.57622 ? 379 SER A O   1 
ATOM   131  C CB  . SER A 1 27  ? -17.31702 1.57709   33.00250  1.000 46.57559 ? 379 SER A CB  1 
ATOM   132  O OG  . SER A 1 27  ? -17.38663 2.94504   32.62115  1.000 46.59540 ? 379 SER A OG  1 
ATOM   133  N N   . GLY A 1 28  ? -16.49227 0.03555   30.47896  1.000 44.72350 ? 380 GLY A N   1 
ATOM   134  C CA  . GLY A 1 28  ? -16.52432 -0.06220  29.03475  1.000 45.78506 ? 380 GLY A CA  1 
ATOM   135  C C   . GLY A 1 28  ? -17.89280 -0.48642  28.54342  1.000 42.48744 ? 380 GLY A C   1 
ATOM   136  O O   . GLY A 1 28  ? -18.86183 -0.47066  29.30954  1.000 40.31191 ? 380 GLY A O   1 
ATOM   137  N N   . ASN A 1 29  ? -17.99090 -0.86413  27.26729  1.000 44.75694 ? 381 ASN A N   1 
ATOM   138  C CA  . ASN A 1 29  ? -19.26202 -1.35796  26.74325  1.000 47.18096 ? 381 ASN A CA  1 
ATOM   139  C C   . ASN A 1 29  ? -19.71168 -2.62372  27.46492  1.000 48.70220 ? 381 ASN A C   1 
ATOM   140  O O   . ASN A 1 29  ? -20.91366 -2.90485  27.53904  1.000 51.55306 ? 381 ASN A O   1 
ATOM   141  C CB  . ASN A 1 29  ? -19.13298 -1.63833  25.24626  1.000 58.28635 ? 381 ASN A CB  1 
ATOM   142  C CG  . ASN A 1 29  ? -18.30227 -2.87360  24.96527  1.000 50.70883 ? 381 ASN A CG  1 
ATOM   143  O OD1 . ASN A 1 29  ? -18.81812 -3.99139  24.96074  1.000 52.67070 ? 381 ASN A OD1 1 
ATOM   144  N ND2 . ASN A 1 29  ? -17.00677 -2.68222  24.75667  1.000 56.71234 ? 381 ASN A ND2 1 
ATOM   145  N N   . PHE A 1 30  ? -18.76096 -3.38777  28.00845  1.000 39.36609 ? 382 PHE A N   1 
ATOM   146  C CA  . PHE A 1 30  ? -19.01502 -4.70352  28.58747  1.000 42.12430 ? 382 PHE A CA  1 
ATOM   147  C C   . PHE A 1 30  ? -19.45961 -4.64255  30.03951  1.000 40.42200 ? 382 PHE A C   1 
ATOM   148  O O   . PHE A 1 30  ? -19.98223 -5.63162  30.55689  1.000 38.29516 ? 382 PHE A O   1 
ATOM   149  C CB  . PHE A 1 30  ? -17.73997 -5.53852  28.52294  1.000 36.41150 ? 382 PHE A CB  1 
ATOM   150  C CG  . PHE A 1 30  ? -16.55311 -4.82001  29.06933  1.000 36.86509 ? 382 PHE A CG  1 
ATOM   151  C CD1 . PHE A 1 30  ? -16.35818 -4.71333  30.44013  1.000 42.93981 ? 382 PHE A CD1 1 
ATOM   152  C CD2 . PHE A 1 30  ? -15.64991 -4.20916  28.21790  1.000 36.82003 ? 382 PHE A CD2 1 
ATOM   153  C CE1 . PHE A 1 30  ? -15.27635 -4.01555  30.94969  1.000 38.11498 ? 382 PHE A CE1 1 
ATOM   154  C CE2 . PHE A 1 30  ? -14.56977 -3.52151  28.71641  1.000 35.05457 ? 382 PHE A CE2 1 
ATOM   155  C CZ  . PHE A 1 30  ? -14.38133 -3.42168  30.08048  1.000 41.07418 ? 382 PHE A CZ  1 
ATOM   156  N N   . GLY A 1 31  ? -19.21486 -3.53180  30.71755  1.000 42.59921 ? 383 GLY A N   1 
ATOM   157  C CA  . GLY A 1 31  ? -19.35986 -3.49170  32.15430  1.000 38.21286 ? 383 GLY A CA  1 
ATOM   158  C C   . GLY A 1 31  ? -18.20543 -2.76040  32.80419  1.000 43.59766 ? 383 GLY A C   1 
ATOM   159  O O   . GLY A 1 31  ? -17.81478 -1.67815  32.35094  1.000 41.28198 ? 383 GLY A O   1 
ATOM   160  N N   . THR A 1 32  ? -17.62590 -3.36488  33.84166  1.000 36.42940 ? 384 THR A N   1 
ATOM   161  C CA  . THR A 1 32  ? -16.77109 -2.66256  34.78278  1.000 36.55976 ? 384 THR A CA  1 
ATOM   162  C C   . THR A 1 32  ? -15.43268 -3.37589  34.95813  1.000 32.23302 ? 384 THR A C   1 
ATOM   163  O O   . THR A 1 32  ? -15.32359 -4.59159  34.78444  1.000 33.85119 ? 384 THR A O   1 
ATOM   164  C CB  . THR A 1 32  ? -17.52518 -2.51653  36.13606  1.000 38.45710 ? 384 THR A CB  1 
ATOM   165  O OG1 . THR A 1 32  ? -18.45043 -1.41906  36.04236  1.000 48.84675 ? 384 THR A OG1 1 
ATOM   166  C CG2 . THR A 1 32  ? -16.59819 -2.26361  37.27494  1.000 49.87350 ? 384 THR A CG2 1 
ATOM   167  N N   . VAL A 1 33  ? -14.40640 -2.59846  35.28615  1.000 33.83678 ? 385 VAL A N   1 
ATOM   168  C CA  . VAL A 1 33  ? -13.13274 -3.13032  35.75482  1.000 33.02672 ? 385 VAL A CA  1 
ATOM   169  C C   . VAL A 1 33  ? -12.95077 -2.70569  37.20394  1.000 31.31158 ? 385 VAL A C   1 
ATOM   170  O O   . VAL A 1 33  ? -13.04299 -1.51239  37.52789  1.000 31.31114 ? 385 VAL A O   1 
ATOM   171  C CB  . VAL A 1 33  ? -11.96751 -2.65026  34.87719  1.000 34.74797 ? 385 VAL A CB  1 
ATOM   172  C CG1 . VAL A 1 33  ? -10.64446 -3.12243  35.45676  1.000 30.90230 ? 385 VAL A CG1 1 
ATOM   173  C CG2 . VAL A 1 33  ? -12.13840 -3.17048  33.43557  1.000 34.47964 ? 385 VAL A CG2 1 
ATOM   174  N N   . LYS A 1 34  ? -12.70560 -3.67497  38.07843  1.000 29.62493 ? 386 LYS A N   1 
ATOM   175  C CA  . LYS A 1 34  ? -12.54240 -3.39787  39.49381  1.000 33.81276 ? 386 LYS A CA  1 
ATOM   176  C C   . LYS A 1 34  ? -11.20855 -3.92170  39.99961  1.000 37.98480 ? 386 LYS A C   1 
ATOM   177  O O   . LYS A 1 34  ? -10.68755 -4.93422  39.52115  1.000 31.33219 ? 386 LYS A O   1 
ATOM   178  C CB  . LYS A 1 34  ? -13.65740 -4.02184  40.32515  1.000 41.34699 ? 386 LYS A CB  1 
ATOM   179  C CG  . LYS A 1 34  ? -14.92899 -3.22609  40.32948  1.000 37.49065 ? 386 LYS A CG  1 
ATOM   180  C CD  . LYS A 1 34  ? -15.83953 -3.69438  41.44868  1.000 44.47107 ? 386 LYS A CD  1 
ATOM   181  C CE  . LYS A 1 34  ? -17.14751 -2.92479  41.44504  1.000 49.90011 ? 386 LYS A CE  1 
ATOM   182  N NZ  . LYS A 1 34  ? -18.02116 -3.42142  40.34703  1.000 64.34646 ? 386 LYS A NZ  1 
ATOM   183  N N   . LYS A 1 35  ? -10.66791 -3.22025  40.98125  1.000 31.41391 ? 387 LYS A N   1 
ATOM   184  C CA  . LYS A 1 35  ? -9.51842  -3.72695  41.69767  1.000 28.25279 ? 387 LYS A CA  1 
ATOM   185  C C   . LYS A 1 35  ? -9.97915  -4.75554  42.71374  1.000 34.92401 ? 387 LYS A C   1 
ATOM   186  O O   . LYS A 1 35  ? -11.08629 -4.66980  43.25819  1.000 39.25604 ? 387 LYS A O   1 
ATOM   187  C CB  . LYS A 1 35  ? -8.76643  -2.59994  42.39509  1.000 32.42808 ? 387 LYS A CB  1 
ATOM   188  C CG  . LYS A 1 35  ? -7.48449  -3.06017  43.07920  1.000 36.32653 ? 387 LYS A CG  1 
ATOM   189  C CD  . LYS A 1 35  ? -6.83504  -1.91647  43.79508  1.000 39.70593 ? 387 LYS A CD  1 
ATOM   190  C CE  . LYS A 1 35  ? -5.44220  -2.26583  44.23281  1.000 32.84052 ? 387 LYS A CE  1 
ATOM   191  N NZ  . LYS A 1 35  ? -4.71538  -1.00371  44.53965  1.000 36.52485 ? 387 LYS A NZ  1 
ATOM   192  N N   . GLY A 1 36  ? -9.12180  -5.74344  42.95902  1.000 28.97960 ? 388 GLY A N   1 
ATOM   193  C CA  . GLY A 1 36  ? -9.47070  -6.79910  43.88390  1.000 29.93139 ? 388 GLY A CA  1 
ATOM   194  C C   . GLY A 1 36  ? -8.24649  -7.44793  44.48895  1.000 31.55902 ? 388 GLY A C   1 
ATOM   195  O O   . GLY A 1 36  ? -7.10024  -7.17824  44.10996  1.000 28.36757 ? 388 GLY A O   1 
ATOM   196  N N   . TYR A 1 37  ? -8.51272  -8.33003  45.44441  1.000 34.80572 ? 389 TYR A N   1 
ATOM   197  C CA  . TYR A 1 37  ? -7.47880  -9.08930  46.12104  1.000 23.67245 ? 389 TYR A CA  1 
ATOM   198  C C   . TYR A 1 37  ? -7.94088  -10.53639 46.14459  1.000 33.12626 ? 389 TYR A C   1 
ATOM   199  O O   . TYR A 1 37  ? -9.08219  -10.81313 46.54149  1.000 37.91018 ? 389 TYR A O   1 
ATOM   200  C CB  . TYR A 1 37  ? -7.23714  -8.54280  47.53823  1.000 26.63436 ? 389 TYR A CB  1 
ATOM   201  C CG  . TYR A 1 37  ? -7.37257  -7.01942  47.64420  1.000 31.61927 ? 389 TYR A CG  1 
ATOM   202  C CD1 . TYR A 1 37  ? -6.36766  -6.16558  47.18274  1.000 29.98781 ? 389 TYR A CD1 1 
ATOM   203  C CD2 . TYR A 1 37  ? -8.51256  -6.44685  48.19418  1.000 36.00063 ? 389 TYR A CD2 1 
ATOM   204  C CE1 . TYR A 1 37  ? -6.49546  -4.77418  47.26546  1.000 32.20943 ? 389 TYR A CE1 1 
ATOM   205  C CE2 . TYR A 1 37  ? -8.65177  -5.06896  48.28562  1.000 38.68667 ? 389 TYR A CE2 1 
ATOM   206  C CZ  . TYR A 1 37  ? -7.64444  -4.23243  47.82287  1.000 39.31632 ? 389 TYR A CZ  1 
ATOM   207  O OH  . TYR A 1 37  ? -7.80588  -2.85497  47.92918  1.000 36.70967 ? 389 TYR A OH  1 
ATOM   208  N N   . TYR A 1 38  ? -7.09257  -11.44769 45.66488  1.000 26.66270 ? 390 TYR A N   1 
ATOM   209  C CA  . TYR A 1 38  ? -7.42962  -12.87051 45.59672  1.000 29.70853 ? 390 TYR A CA  1 
ATOM   210  C C   . TYR A 1 38  ? -6.45775  -13.67898 46.44294  1.000 33.99998 ? 390 TYR A C   1 
ATOM   211  O O   . TYR A 1 38  ? -5.24211  -13.58288 46.26513  1.000 34.51189 ? 390 TYR A O   1 
ATOM   212  C CB  . TYR A 1 38  ? -7.42182  -13.40682 44.15831  1.000 32.93663 ? 390 TYR A CB  1 
ATOM   213  C CG  . TYR A 1 38  ? -8.10974  -14.75046 44.04966  1.000 38.39954 ? 390 TYR A CG  1 
ATOM   214  C CD1 . TYR A 1 38  ? -9.49881  -14.83750 44.12087  1.000 35.01203 ? 390 TYR A CD1 1 
ATOM   215  C CD2 . TYR A 1 38  ? -7.38301  -15.92832 43.89308  1.000 37.02313 ? 390 TYR A CD2 1 
ATOM   216  C CE1 . TYR A 1 38  ? -10.14331 -16.05133 44.03919  1.000 40.39687 ? 390 TYR A CE1 1 
ATOM   217  C CE2 . TYR A 1 38  ? -8.02447  -17.16372 43.79919  1.000 37.36517 ? 390 TYR A CE2 1 
ATOM   218  C CZ  . TYR A 1 38  ? -9.40980  -17.20887 43.87698  1.000 44.56621 ? 390 TYR A CZ  1 
ATOM   219  O OH  . TYR A 1 38  ? -10.08725 -18.39819 43.79792  1.000 43.71611 ? 390 TYR A OH  1 
ATOM   220  N N   . GLN A 1 39  ? -6.99843  -14.47151 47.36310  1.000 41.15327 ? 391 GLN A N   1 
ATOM   221  C CA  . GLN A 1 39  ? -6.16802  -15.30386 48.22767  1.000 46.92631 ? 391 GLN A CA  1 
ATOM   222  C C   . GLN A 1 39  ? -5.60700  -16.48663 47.45079  1.000 51.34975 ? 391 GLN A C   1 
ATOM   223  O O   . GLN A 1 39  ? -6.36269  -17.25976 46.85351  1.000 47.78204 ? 391 GLN A O   1 
ATOM   224  C CB  . GLN A 1 39  ? -6.98290  -15.80304 49.42239  1.000 60.43103 ? 391 GLN A CB  1 
ATOM   225  C CG  . GLN A 1 39  ? -6.32069  -16.92506 50.22320  1.000 56.59954 ? 391 GLN A CG  1 
ATOM   226  C CD  . GLN A 1 39  ? -5.11130  -16.45641 51.01289  1.000 54.46187 ? 391 GLN A CD  1 
ATOM   227  O OE1 . GLN A 1 39  ? -3.97549  -16.76956 50.65540  1.000 61.74745 ? 391 GLN A OE1 1 
ATOM   228  N NE2 . GLN A 1 39  ? -5.34778  -15.71411 52.10049  1.000 53.89668 ? 391 GLN A NE2 1 
ATOM   229  N N   . MET A 1 40  ? -4.28001  -16.63861 47.46988  1.000 41.48852 ? 392 MET A N   1 
ATOM   230  C CA  . MET A 1 40  ? -3.61002  -17.69149 46.71777  1.000 53.29223 ? 392 MET A CA  1 
ATOM   231  C C   . MET A 1 40  ? -2.64021  -18.43801 47.61306  1.000 63.78693 ? 392 MET A C   1 
ATOM   232  O O   . MET A 1 40  ? -1.69928  -17.83526 48.14005  1.000 68.91408 ? 392 MET A O   1 
ATOM   233  C CB  . MET A 1 40  ? -2.86128  -17.11592 45.52180  1.000 56.18549 ? 392 MET A CB  1 
ATOM   234  C CG  . MET A 1 40  ? -3.28313  -17.72538 44.20896  1.000 63.97198 ? 392 MET A CG  1 
ATOM   235  S SD  . MET A 1 40  ? -3.07249  -16.47545 42.95960  1.000 55.14652 ? 392 MET A SD  1 
ATOM   236  C CE  . MET A 1 40  ? -3.99047  -15.15699 43.70198  1.000 48.02558 ? 392 MET A CE  1 
ATOM   237  N N   . LYS A 1 41  ? -2.84727  -19.75117 47.74062  1.000 65.53834 ? 393 LYS A N   1 
ATOM   238  C CA  . LYS A 1 41  ? -1.95841  -20.65275 48.46715  1.000 60.55065 ? 393 LYS A CA  1 
ATOM   239  C C   . LYS A 1 41  ? -1.57361  -20.05720 49.81817  1.000 60.08563 ? 393 LYS A C   1 
ATOM   240  O O   . LYS A 1 41  ? -2.11569  -20.46963 50.84860  1.000 68.12992 ? 393 LYS A O   1 
ATOM   241  C CB  . LYS A 1 41  ? -0.72203  -20.98355 47.62271  1.000 68.19222 ? 393 LYS A CB  1 
ATOM   242  C CG  . LYS A 1 41  ? -0.13392  -22.36552 47.90806  1.000 58.25404 ? 393 LYS A CG  1 
ATOM   243  C CD  . LYS A 1 41  ? 1.07297   -22.67780 47.02703  1.000 67.19104 ? 393 LYS A CD  1 
ATOM   244  C CE  . LYS A 1 41  ? 0.67932   -23.38132 45.72986  1.000 68.20826 ? 393 LYS A CE  1 
ATOM   245  N NZ  . LYS A 1 41  ? 1.87430   -23.92810 45.01404  1.000 71.67500 ? 393 LYS A NZ  1 
ATOM   246  N N   . LYS A 1 42  ? -0.67451  -19.06794 49.83774  1.000 54.66775 ? 394 LYS A N   1 
ATOM   247  C CA  . LYS A 1 42  ? -0.37786  -18.36713 51.08413  1.000 42.27311 ? 394 LYS A CA  1 
ATOM   248  C C   . LYS A 1 42  ? -0.60466  -16.86441 51.00962  1.000 48.21406 ? 394 LYS A C   1 
ATOM   249  O O   . LYS A 1 42  ? -1.29454  -16.30589 51.87096  1.000 44.62640 ? 394 LYS A O   1 
ATOM   250  C CB  . LYS A 1 42  ? 1.06259   -18.63500 51.53286  1.000 47.98304 ? 394 LYS A CB  1 
ATOM   251  C CG  . LYS A 1 42  ? 1.23518   -18.41768 53.02883  1.000 42.17718 ? 394 LYS A CG  1 
ATOM   252  C CD  . LYS A 1 42  ? 2.65436   -18.64458 53.46586  1.000 44.43293 ? 394 LYS A CD  1 
ATOM   253  C CE  . LYS A 1 42  ? 2.72662   -18.80105 54.97906  1.000 41.32445 ? 394 LYS A CE  1 
ATOM   254  N NZ  . LYS A 1 42  ? 4.09791   -19.18626 55.41919  1.000 37.96983 ? 394 LYS A NZ  1 
ATOM   255  N N   . VAL A 1 43  ? -0.01218  -16.18016 50.03211  1.000 47.10943 ? 395 VAL A N   1 
ATOM   256  C CA  . VAL A 1 43  ? -0.11341  -14.72531 49.95456  1.000 37.40492 ? 395 VAL A CA  1 
ATOM   257  C C   . VAL A 1 43  ? -1.43239  -14.36477 49.29273  1.000 42.77232 ? 395 VAL A C   1 
ATOM   258  O O   . VAL A 1 43  ? -2.08830  -15.21846 48.68893  1.000 39.08998 ? 395 VAL A O   1 
ATOM   259  C CB  . VAL A 1 43  ? 1.06070   -14.11713 49.17272  1.000 36.55305 ? 395 VAL A CB  1 
ATOM   260  C CG1 . VAL A 1 43  ? 2.38339   -14.49477 49.80537  1.000 39.54102 ? 395 VAL A CG1 1 
ATOM   261  C CG2 . VAL A 1 43  ? 1.00199   -14.55669 47.72392  1.000 37.90432 ? 395 VAL A CG2 1 
ATOM   262  N N   . VAL A 1 44  ? -1.82960  -13.10780 49.39430  1.000 39.09590 ? 396 VAL A N   1 
ATOM   263  C CA  . VAL A 1 44  ? -2.91267  -12.59425 48.57144  1.000 38.71158 ? 396 VAL A CA  1 
ATOM   264  C C   . VAL A 1 44  ? -2.28154  -11.85339 47.39752  1.000 39.19370 ? 396 VAL A C   1 
ATOM   265  O O   . VAL A 1 44  ? -1.15173  -11.35202 47.48564  1.000 31.91988 ? 396 VAL A O   1 
ATOM   266  C CB  . VAL A 1 44  ? -3.87448  -11.73735 49.42515  1.000 34.26919 ? 396 VAL A CB  1 
ATOM   267  C CG1 . VAL A 1 44  ? -4.81655  -10.91831 48.58228  1.000 39.86019 ? 396 VAL A CG1 1 
ATOM   268  C CG2 . VAL A 1 44  ? -4.69594  -12.68271 50.30156  1.000 44.43484 ? 396 VAL A CG2 1 
ATOM   269  N N   . LYS A 1 45  ? -2.96088  -11.86415 46.25512  1.000 29.99849 ? 397 LYS A N   1 
ATOM   270  C CA  . LYS A 1 45  ? -2.43607  -11.22520 45.05763  1.000 27.58141 ? 397 LYS A CA  1 
ATOM   271  C C   . LYS A 1 45  ? -3.40702  -10.16764 44.57108  1.000 30.19132 ? 397 LYS A C   1 
ATOM   272  O O   . LYS A 1 45  ? -4.61923  -10.39964 44.53488  1.000 29.83748 ? 397 LYS A O   1 
ATOM   273  C CB  . LYS A 1 45  ? -2.17222  -12.23524 43.93141  1.000 34.86629 ? 397 LYS A CB  1 
ATOM   274  C CG  . LYS A 1 45  ? -1.50523  -11.61269 42.70402  1.000 36.10861 ? 397 LYS A CG  1 
ATOM   275  C CD  . LYS A 1 45  ? -0.68792  -12.62588 41.93208  1.000 44.56982 ? 397 LYS A CD  1 
ATOM   276  C CE  . LYS A 1 45  ? 0.04040   -11.97702 40.76701  1.000 40.11217 ? 397 LYS A CE  1 
ATOM   277  N NZ  . LYS A 1 45  ? 1.18589   -11.14125 41.18027  1.000 34.34037 ? 397 LYS A NZ  1 
ATOM   278  N N   . THR A 1 46  ? -2.86936  -9.00504  44.20983  1.000 26.65791 ? 398 THR A N   1 
ATOM   279  C CA  . THR A 1 46  ? -3.69993  -7.91306  43.72792  1.000 27.41932 ? 398 THR A CA  1 
ATOM   280  C C   . THR A 1 46  ? -4.13287  -8.22202  42.29685  1.000 26.99389 ? 398 THR A C   1 
ATOM   281  O O   . THR A 1 46  ? -3.30307  -8.56247  41.44834  1.000 25.90285 ? 398 THR A O   1 
ATOM   282  C CB  . THR A 1 46  ? -2.94408  -6.58226  43.79813  1.000 30.60037 ? 398 THR A CB  1 
ATOM   283  O OG1 . THR A 1 46  ? -2.51090  -6.33200  45.14806  1.000 30.44339 ? 398 THR A OG1 1 
ATOM   284  C CG2 . THR A 1 46  ? -3.83400  -5.42529  43.34737  1.000 30.16192 ? 398 THR A CG2 1 
ATOM   285  N N   . VAL A 1 47  ? -5.43865  -8.12170  42.03734  1.000 28.85689 ? 399 VAL A N   1 
ATOM   286  C CA  . VAL A 1 47  ? -6.00281  -8.48356  40.74827  1.000 26.75392 ? 399 VAL A CA  1 
ATOM   287  C C   . VAL A 1 47  ? -6.83591  -7.34069  40.19085  1.000 28.51130 ? 399 VAL A C   1 
ATOM   288  O O   . VAL A 1 47  ? -7.32639  -6.47165  40.91998  1.000 27.34589 ? 399 VAL A O   1 
ATOM   289  C CB  . VAL A 1 47  ? -6.85675  -9.76160  40.83895  1.000 26.02934 ? 399 VAL A CB  1 
ATOM   290  C CG1 . VAL A 1 47  ? -6.01807  -10.92449 41.22349  1.000 21.66193 ? 399 VAL A CG1 1 
ATOM   291  C CG2 . VAL A 1 47  ? -8.02097  -9.56516  41.81582  1.000 28.89399 ? 399 VAL A CG2 1 
ATOM   292  N N   . ALA A 1 48  ? -6.94315  -7.33220  38.86932  1.000 28.04154 ? 400 ALA A N   1 
ATOM   293  C CA  . ALA A 1 48  ? -7.86497  -6.50169  38.12154  1.000 27.43586 ? 400 ALA A CA  1 
ATOM   294  C C   . ALA A 1 48  ? -8.94992  -7.42850  37.59205  1.000 30.44729 ? 400 ALA A C   1 
ATOM   295  O O   . ALA A 1 48  ? -8.63929  -8.49750  37.04392  1.000 31.88217 ? 400 ALA A O   1 
ATOM   296  C CB  . ALA A 1 48  ? -7.14665  -5.78377  36.97366  1.000 25.33835 ? 400 ALA A CB  1 
ATOM   297  N N   . VAL A 1 49  ? -10.21268 -7.05514  37.80083  1.000 31.27684 ? 401 VAL A N   1 
ATOM   298  C CA  . VAL A 1 49  ? -11.34290 -7.94595  37.54601  1.000 30.09020 ? 401 VAL A CA  1 
ATOM   299  C C   . VAL A 1 49  ? -12.27928 -7.27548  36.54749  1.000 28.37313 ? 401 VAL A C   1 
ATOM   300  O O   . VAL A 1 49  ? -12.77970 -6.16983  36.79411  1.000 31.85994 ? 401 VAL A O   1 
ATOM   301  C CB  . VAL A 1 49  ? -12.08097 -8.31522  38.84385  1.000 26.90218 ? 401 VAL A CB  1 
ATOM   302  C CG1 . VAL A 1 49  ? -13.15999 -9.33871  38.56434  1.000 30.97954 ? 401 VAL A CG1 1 
ATOM   303  C CG2 . VAL A 1 49  ? -11.10103 -8.86990  39.86648  1.000 23.82388 ? 401 VAL A CG2 1 
ATOM   304  N N   . LYS A 1 50  ? -12.47915 -7.92784  35.41117  1.000 28.41055 ? 402 LYS A N   1 
ATOM   305  C CA  . LYS A 1 50  ? -13.43305 -7.49097  34.40082  1.000 28.46886 ? 402 LYS A CA  1 
ATOM   306  C C   . LYS A 1 50  ? -14.78556 -8.10660  34.73693  1.000 32.98753 ? 402 LYS A C   1 
ATOM   307  O O   . LYS A 1 50  ? -14.89972 -9.33240  34.81218  1.000 31.79459 ? 402 LYS A O   1 
ATOM   308  C CB  . LYS A 1 50  ? -12.96132 -7.92340  33.01055  1.000 29.53105 ? 402 LYS A CB  1 
ATOM   309  C CG  . LYS A 1 50  ? -14.00641 -7.80481  31.90512  1.000 36.55579 ? 402 LYS A CG  1 
ATOM   310  C CD  . LYS A 1 50  ? -13.42639 -8.21730  30.56177  1.000 38.13923 ? 402 LYS A CD  1 
ATOM   311  C CE  . LYS A 1 50  ? -14.43582 -7.98057  29.45097  1.000 48.25289 ? 402 LYS A CE  1 
ATOM   312  N NZ  . LYS A 1 50  ? -13.86896 -8.19510  28.08028  1.000 44.08712 ? 402 LYS A NZ  1 
ATOM   313  N N   . ILE A 1 51  ? -15.79590 -7.26117  34.93786  1.000 30.47920 ? 403 ILE A N   1 
ATOM   314  C CA  . ILE A 1 51  ? -17.11165 -7.66711  35.43710  1.000 35.12937 ? 403 ILE A CA  1 
ATOM   315  C C   . ILE A 1 51  ? -18.17133 -7.29915  34.40443  1.000 33.40755 ? 403 ILE A C   1 
ATOM   316  O O   . ILE A 1 51  ? -18.33666 -6.11579  34.07255  1.000 33.13290 ? 403 ILE A O   1 
ATOM   317  C CB  . ILE A 1 51  ? -17.42862 -6.99068  36.77874  1.000 34.12863 ? 403 ILE A CB  1 
ATOM   318  C CG1 . ILE A 1 51  ? -16.30612 -7.26451  37.78585  1.000 32.09000 ? 403 ILE A CG1 1 
ATOM   319  C CG2 . ILE A 1 51  ? -18.79724 -7.44207  37.30048  1.000 31.45144 ? 403 ILE A CG2 1 
ATOM   320  C CD1 . ILE A 1 51  ? -16.46795 -6.48068  39.07269  1.000 41.80583 ? 403 ILE A CD1 1 
ATOM   321  N N   . LEU A 1 52  ? -18.92584 -8.29234  33.94356  1.000 34.10556 ? 404 LEU A N   1 
ATOM   322  C CA  . LEU A 1 52  ? -19.94610 -8.03276  32.92651  1.000 36.61823 ? 404 LEU A CA  1 
ATOM   323  C C   . LEU A 1 52  ? -21.16176 -7.30733  33.51384  1.000 33.20873 ? 404 LEU A C   1 
ATOM   324  O O   . LEU A 1 52  ? -21.63567 -7.62991  34.60543  1.000 35.25483 ? 404 LEU A O   1 
ATOM   325  C CB  . LEU A 1 52  ? -20.37756 -9.33777  32.25744  1.000 36.64734 ? 404 LEU A CB  1 
ATOM   326  C CG  . LEU A 1 52  ? -19.26446 -10.07932 31.50120  1.000 34.22177 ? 404 LEU A CG  1 
ATOM   327  C CD1 . LEU A 1 52  ? -19.85019 -11.27141 30.76626  1.000 35.50631 ? 404 LEU A CD1 1 
ATOM   328  C CD2 . LEU A 1 52  ? -18.50739 -9.15962  30.53589  1.000 36.44990 ? 404 LEU A CD2 1 
ATOM   329  N N   . LYS A 1 53  ? -21.65621 -6.31932  32.77177  1.000 34.58829 ? 405 LYS A N   1 
ATOM   330  C CA  . LYS A 1 53  ? -22.81881 -5.53482  33.17725  1.000 42.62323 ? 405 LYS A CA  1 
ATOM   331  C C   . LYS A 1 53  ? -24.06452 -6.41124  33.28383  1.000 39.26758 ? 405 LYS A C   1 
ATOM   332  O O   . LYS A 1 53  ? -24.15773 -7.48261  32.67527  1.000 35.87204 ? 405 LYS A O   1 
ATOM   333  C CB  . LYS A 1 53  ? -23.08647 -4.40266  32.17376  1.000 38.02045 ? 405 LYS A CB  1 
ATOM   334  C CG  . LYS A 1 53  ? -23.58394 -4.85376  30.77189  1.000 41.37261 ? 405 LYS A CG  1 
ATOM   335  C CD  . LYS A 1 53  ? -25.12238 -4.66259  30.57585  1.000 58.42849 ? 405 LYS A CD  1 
ATOM   336  C CE  . LYS A 1 53  ? -25.68255 -5.34277  29.29453  1.000 53.10625 ? 405 LYS A CE  1 
ATOM   337  N NZ  . LYS A 1 53  ? -27.18202 -5.67723  29.27581  1.000 35.64497 ? 405 LYS A NZ  1 
ATOM   338  N N   . ASN A 1 54  ? -25.02865 -5.92572  34.07915  1.000 39.54869 ? 406 ASN A N   1 
ATOM   339  C CA  . ASN A 1 54  ? -26.38729 -6.46744  34.15161  1.000 45.15516 ? 406 ASN A CA  1 
ATOM   340  C C   . ASN A 1 54  ? -26.38175 -7.98390  34.32410  1.000 49.22728 ? 406 ASN A C   1 
ATOM   341  O O   . ASN A 1 54  ? -27.07065 -8.71835  33.60950  1.000 47.93066 ? 406 ASN A O   1 
ATOM   342  C CB  . ASN A 1 54  ? -27.19293 -6.06080  32.91878  1.000 42.13497 ? 406 ASN A CB  1 
ATOM   343  C CG  . ASN A 1 54  ? -28.68146 -6.34525  33.06648  1.000 47.14210 ? 406 ASN A CG  1 
ATOM   344  O OD1 . ASN A 1 54  ? -29.19125 -6.50014  34.18007  1.000 45.07237 ? 406 ASN A OD1 1 
ATOM   345  N ND2 . ASN A 1 54  ? -29.38174 -6.41856  31.94099  1.000 41.72596 ? 406 ASN A ND2 1 
ATOM   346  N N   . GLU A 1 55  ? -25.56019 -8.45086  35.26960  1.000 42.36275 ? 407 GLU A N   1 
ATOM   347  C CA  . GLU A 1 55  ? -25.44738 -9.86878  35.62478  1.000 49.52828 ? 407 GLU A CA  1 
ATOM   348  C C   . GLU A 1 55  ? -25.12072 -10.75519 34.42108  1.000 42.06214 ? 407 GLU A C   1 
ATOM   349  O O   . GLU A 1 55  ? -25.36642 -11.96518 34.45479  1.000 45.08972 ? 407 GLU A O   1 
ATOM   350  C CB  . GLU A 1 55  ? -26.72021 -10.36175 36.32050  1.000 55.41831 ? 407 GLU A CB  1 
ATOM   351  C CG  . GLU A 1 55  ? -26.96875 -9.70744  37.67262  1.000 59.63217 ? 407 GLU A CG  1 
ATOM   352  C CD  . GLU A 1 55  ? -28.20521 -10.25453 38.35722  1.000 68.61324 ? 407 GLU A CD  1 
ATOM   353  O OE1 . GLU A 1 55  ? -29.18401 -10.56190 37.64390  1.000 73.74671 ? 407 GLU A OE1 1 
ATOM   354  O OE2 . GLU A 1 55  ? -28.19463 -10.38827 39.59993  1.000 70.74384 ? 407 GLU A OE2 1 
ATOM   355  N N   . ALA A 1 56  ? -24.55603 -10.15933 33.36592  1.000 38.65887 ? 408 ALA A N   1 
ATOM   356  C CA  . ALA A 1 56  ? -24.14320 -10.86537 32.15046  1.000 37.81422 ? 408 ALA A CA  1 
ATOM   357  C C   . ALA A 1 56  ? -25.34185 -11.43214 31.39168  1.000 49.56649 ? 408 ALA A C   1 
ATOM   358  O O   . ALA A 1 56  ? -25.27050 -12.52890 30.82931  1.000 44.20467 ? 408 ALA A O   1 
ATOM   359  C CB  . ALA A 1 56  ? -23.12861 -11.97294 32.45529  1.000 38.45392 ? 408 ALA A CB  1 
ATOM   360  N N   . ASN A 1 57  ? -26.45036 -10.68173 31.36587  1.000 39.31913 ? 409 ASN A N   1 
ATOM   361  C CA  . ASN A 1 57  ? -27.62744 -11.16182 30.64445  1.000 39.24846 ? 409 ASN A CA  1 
ATOM   362  C C   . ASN A 1 57  ? -27.38483 -11.23161 29.13724  1.000 43.77719 ? 409 ASN A C   1 
ATOM   363  O O   . ASN A 1 57  ? -27.95832 -12.09339 28.45653  1.000 47.07724 ? 409 ASN A O   1 
ATOM   364  C CB  . ASN A 1 57  ? -28.83042 -10.27627 30.97090  1.000 39.73489 ? 409 ASN A CB  1 
ATOM   365  C CG  . ASN A 1 57  ? -29.47843 -10.65043 32.28823  1.000 35.26035 ? 409 ASN A CG  1 
ATOM   366  O OD1 . ASN A 1 57  ? -29.51171 -11.82330 32.65018  1.000 41.18613 ? 409 ASN A OD1 1 
ATOM   367  N ND2 . ASN A 1 57  ? -29.99343 -9.65922  33.01139  1.000 43.40752 ? 409 ASN A ND2 1 
ATOM   368  N N   . ASP A 1 58  ? -26.55028 -10.34489 28.60873  1.000 41.67652 ? 410 ASP A N   1 
ATOM   369  C CA  . ASP A 1 58  ? -26.17583 -10.29545 27.19582  1.000 41.56410 ? 410 ASP A CA  1 
ATOM   370  C C   . ASP A 1 58  ? -25.34143 -11.52008 26.81014  1.000 51.83598 ? 410 ASP A C   1 
ATOM   371  O O   . ASP A 1 58  ? -24.17743 -11.62102 27.23514  1.000 49.18266 ? 410 ASP A O   1 
ATOM   372  C CB  . ASP A 1 58  ? -25.39372 -8.99210  26.92804  1.000 41.82884 ? 410 ASP A CB  1 
ATOM   373  C CG  . ASP A 1 58  ? -25.16691 -8.71443  25.43925  1.000 47.18190 ? 410 ASP A CG  1 
ATOM   374  O OD1 . ASP A 1 58  ? -25.26797 -9.65531  24.61497  1.000 51.98480 ? 410 ASP A OD1 1 
ATOM   375  O OD2 . ASP A 1 58  ? -24.87515 -7.54595  25.09662  1.000 37.00404 ? 410 ASP A OD2 1 
ATOM   376  N N   . PRO A 1 59  ? -25.86603 -12.45168 26.00416  1.000 49.04730 ? 411 PRO A N   1 
ATOM   377  C CA  . PRO A 1 59  ? -25.04805 -13.61603 25.62058  1.000 43.21471 ? 411 PRO A CA  1 
ATOM   378  C C   . PRO A 1 59  ? -23.80672 -13.24202 24.82058  1.000 52.61737 ? 411 PRO A C   1 
ATOM   379  O O   . PRO A 1 59  ? -22.80183 -13.96100 24.89524  1.000 45.54244 ? 411 PRO A O   1 
ATOM   380  C CB  . PRO A 1 59  ? -26.02085 -14.47520 24.80169  1.000 49.41246 ? 411 PRO A CB  1 
ATOM   381  C CG  . PRO A 1 59  ? -27.05165 -13.50486 24.29109  1.000 57.64485 ? 411 PRO A CG  1 
ATOM   382  C CD  . PRO A 1 59  ? -27.20311 -12.47536 25.38003  1.000 49.84171 ? 411 PRO A CD  1 
ATOM   383  N N   . ALA A 1 60  ? -23.84254 -12.13389 24.06691  1.000 45.56458 ? 412 ALA A N   1 
ATOM   384  C CA  . ALA A 1 60  ? -22.66047 -11.69041 23.33359  1.000 50.65600 ? 412 ALA A CA  1 
ATOM   385  C C   . ALA A 1 60  ? -21.51690 -11.33623 24.28318  1.000 54.58781 ? 412 ALA A C   1 
ATOM   386  O O   . ALA A 1 60  ? -20.34553 -11.62320 23.99473  1.000 45.08943 ? 412 ALA A O   1 
ATOM   387  C CB  . ALA A 1 60  ? -23.01404 -10.49684 22.44006  1.000 50.49014 ? 412 ALA A CB  1 
ATOM   388  N N   . LEU A 1 61  ? -21.83559 -10.70317 25.41876  1.000 47.14555 ? 413 LEU A N   1 
ATOM   389  C CA  . LEU A 1 61  ? -20.80959 -10.42274 26.41959  1.000 42.72519 ? 413 LEU A CA  1 
ATOM   390  C C   . LEU A 1 61  ? -20.33106 -11.70192 27.09419  1.000 39.36858 ? 413 LEU A C   1 
ATOM   391  O O   . LEU A 1 61  ? -19.13832 -11.83907 27.39365  1.000 41.32990 ? 413 LEU A O   1 
ATOM   392  C CB  . LEU A 1 61  ? -21.34167 -9.43836  27.45736  1.000 35.72818 ? 413 LEU A CB  1 
ATOM   393  C CG  . LEU A 1 61  ? -21.51910 -8.02008  26.91608  1.000 47.72676 ? 413 LEU A CG  1 
ATOM   394  C CD1 . LEU A 1 61  ? -22.11883 -7.09090  27.97387  1.000 37.91236 ? 413 LEU A CD1 1 
ATOM   395  C CD2 . LEU A 1 61  ? -20.18338 -7.49394  26.38955  1.000 41.89108 ? 413 LEU A CD2 1 
ATOM   396  N N   . LYS A 1 62  ? -21.24500 -12.64807 27.34293  1.000 38.17757 ? 414 LYS A N   1 
ATOM   397  C CA  . LYS A 1 62  ? -20.85510 -13.91734 27.95395  1.000 44.67645 ? 414 LYS A CA  1 
ATOM   398  C C   . LYS A 1 62  ? -19.94833 -14.71973 27.02913  1.000 48.90785 ? 414 LYS A C   1 
ATOM   399  O O   . LYS A 1 62  ? -18.94625 -15.29318 27.47813  1.000 43.71263 ? 414 LYS A O   1 
ATOM   400  C CB  . LYS A 1 62  ? -22.09332 -14.73028 28.31297  1.000 48.96229 ? 414 LYS A CB  1 
ATOM   401  C CG  . LYS A 1 62  ? -22.21775 -15.07415 29.78396  1.000 50.44124 ? 414 LYS A CG  1 
ATOM   402  C CD  . LYS A 1 62  ? -23.39136 -16.02542 30.03093  1.000 58.54543 ? 414 LYS A CD  1 
ATOM   403  C CE  . LYS A 1 62  ? -24.70644 -15.45153 29.51124  1.000 57.09217 ? 414 LYS A CE  1 
ATOM   404  N NZ  . LYS A 1 62  ? -25.83889 -16.41303 29.64977  1.000 66.36653 ? 414 LYS A NZ  1 
ATOM   405  N N   . ASP A 1 63  ? -20.29589 -14.77969 25.73830  1.000 46.41250 ? 415 ASP A N   1 
ATOM   406  C CA  . ASP A 1 63  ? -19.44615 -15.43963 24.75035  1.000 42.12724 ? 415 ASP A CA  1 
ATOM   407  C C   . ASP A 1 63  ? -18.05911 -14.81312 24.71599  1.000 44.69676 ? 415 ASP A C   1 
ATOM   408  O O   . ASP A 1 63  ? -17.04510 -15.52102 24.71492  1.000 42.47255 ? 415 ASP A O   1 
ATOM   409  C CB  . ASP A 1 63  ? -20.08244 -15.35156 23.35928  1.000 57.22015 ? 415 ASP A CB  1 
ATOM   410  C CG  . ASP A 1 63  ? -21.45291 -16.00902 23.28531  1.000 67.88114 ? 415 ASP A CG  1 
ATOM   411  O OD1 . ASP A 1 63  ? -21.83323 -16.70571 24.25198  1.000 68.54478 ? 415 ASP A OD1 1 
ATOM   412  O OD2 . ASP A 1 63  ? -22.15155 -15.81235 22.25650  1.000 71.03057 ? 415 ASP A OD2 1 
ATOM   413  N N   . GLU A 1 64  ? -18.00237 -13.47626 24.66852  1.000 38.39273 ? 416 GLU A N   1 
ATOM   414  C CA  . GLU A 1 64  ? -16.72870 -12.77203 24.54710  1.000 40.90210 ? 416 GLU A CA  1 
ATOM   415  C C   . GLU A 1 64  ? -15.82160 -13.06365 25.73891  1.000 45.71824 ? 416 GLU A C   1 
ATOM   416  O O   . GLU A 1 64  ? -14.62644 -13.33572 25.57371  1.000 40.58805 ? 416 GLU A O   1 
ATOM   417  C CB  . GLU A 1 64  ? -16.98221 -11.26656 24.39882  1.000 44.36314 ? 416 GLU A CB  1 
ATOM   418  C CG  . GLU A 1 64  ? -15.77856 -10.38248 24.68707  1.000 43.40995 ? 416 GLU A CG  1 
ATOM   419  C CD  . GLU A 1 64  ? -16.14570 -8.90090  24.80931  1.000 62.82454 ? 416 GLU A CD  1 
ATOM   420  O OE1 . GLU A 1 64  ? -16.73007 -8.34501  23.85071  1.000 64.28711 ? 416 GLU A OE1 1 
ATOM   421  O OE2 . GLU A 1 64  ? -15.85350 -8.29169  25.86821  1.000 58.52618 ? 416 GLU A OE2 1 
ATOM   422  N N   . LEU A 1 65  ? -16.37368 -13.01400 26.95172  1.000 36.65303 ? 417 LEU A N   1 
ATOM   423  C CA  . LEU A 1 65  ? -15.56753 -13.28035 28.14068  1.000 38.57557 ? 417 LEU A CA  1 
ATOM   424  C C   . LEU A 1 65  ? -15.03702 -14.71154 28.15054  1.000 36.92459 ? 417 LEU A C   1 
ATOM   425  O O   . LEU A 1 65  ? -13.87948 -14.95223 28.50921  1.000 34.29144 ? 417 LEU A O   1 
ATOM   426  C CB  . LEU A 1 65  ? -16.39202 -13.01578 29.39500  1.000 41.06112 ? 417 LEU A CB  1 
ATOM   427  C CG  . LEU A 1 65  ? -15.59187 -13.04110 30.69098  1.000 41.80804 ? 417 LEU A CG  1 
ATOM   428  C CD1 . LEU A 1 65  ? -15.98282 -11.86527 31.55928  1.000 41.58460 ? 417 LEU A CD1 1 
ATOM   429  C CD2 . LEU A 1 65  ? -15.88988 -14.33480 31.39836  1.000 46.05313 ? 417 LEU A CD2 1 
ATOM   430  N N   . LEU A 1 66  ? -15.87193 -15.67528 27.76561  1.000 41.79192 ? 418 LEU A N   1 
ATOM   431  C CA  . LEU A 1 66  ? -15.44276 -17.07288 27.76477  1.000 44.81853 ? 418 LEU A CA  1 
ATOM   432  C C   . LEU A 1 66  ? -14.35647 -17.32621 26.72407  1.000 37.46003 ? 418 LEU A C   1 
ATOM   433  O O   . LEU A 1 66  ? -13.40488 -18.07610 26.98047  1.000 43.34933 ? 418 LEU A O   1 
ATOM   434  C CB  . LEU A 1 66  ? -16.64891 -17.97643 27.51954  1.000 49.63182 ? 418 LEU A CB  1 
ATOM   435  C CG  . LEU A 1 66  ? -17.66983 -17.96920 28.66094  1.000 61.92709 ? 418 LEU A CG  1 
ATOM   436  C CD1 . LEU A 1 66  ? -18.97826 -18.67606 28.25645  1.000 53.49152 ? 418 LEU A CD1 1 
ATOM   437  C CD2 . LEU A 1 66  ? -17.05923 -18.58142 29.92844  1.000 46.87813 ? 418 LEU A CD2 1 
ATOM   438  N N   . ALA A 1 67  ? -14.48789 -16.71644 25.54181  1.000 40.95294 ? 419 ALA A N   1 
ATOM   439  C CA  . ALA A 1 67  ? -13.46117 -16.83798 24.50993  1.000 44.14601 ? 419 ALA A CA  1 
ATOM   440  C C   . ALA A 1 67  ? -12.18294 -16.12038 24.92217  1.000 39.35538 ? 419 ALA A C   1 
ATOM   441  O O   . ALA A 1 67  ? -11.07076 -16.61320 24.68717  1.000 39.01132 ? 419 ALA A O   1 
ATOM   442  C CB  . ALA A 1 67  ? -13.98772 -16.27343 23.19233  1.000 38.98517 ? 419 ALA A CB  1 
ATOM   443  N N   . GLU A 1 68  ? -12.33641 -14.93268 25.50293  1.000 36.96370 ? 420 GLU A N   1 
ATOM   444  C CA  . GLU A 1 68  ? -11.23586 -14.21228 26.12607  1.000 39.91268 ? 420 GLU A CA  1 
ATOM   445  C C   . GLU A 1 68  ? -10.44674 -15.11250 27.06797  1.000 34.43181 ? 420 GLU A C   1 
ATOM   446  O O   . GLU A 1 68  ? -9.22377  -15.24372 26.94680  1.000 33.52885 ? 420 GLU A O   1 
ATOM   447  C CB  . GLU A 1 68  ? -11.81972 -13.02254 26.89253  1.000 39.97265 ? 420 GLU A CB  1 
ATOM   448  C CG  . GLU A 1 68  ? -10.87458 -11.93448 27.24196  1.000 47.08192 ? 420 GLU A CG  1 
ATOM   449  C CD  . GLU A 1 68  ? -11.61566 -10.71092 27.74417  1.000 47.60279 ? 420 GLU A CD  1 
ATOM   450  O OE1 . GLU A 1 68  ? -12.85228 -10.80276 28.00396  1.000 43.91785 ? 420 GLU A OE1 1 
ATOM   451  O OE2 . GLU A 1 68  ? -10.96113 -9.66187  27.87939  1.000 43.95734 ? 420 GLU A OE2 1 
ATOM   452  N N   . ALA A 1 69  ? -11.13682 -15.72166 28.03447  1.000 31.82098 ? 421 ALA A N   1 
ATOM   453  C CA  . ALA A 1 69  ? -10.46202 -16.55789 29.02514  1.000 32.69740 ? 421 ALA A CA  1 
ATOM   454  C C   . ALA A 1 69  ? -9.78717  -17.75978 28.37385  1.000 34.00424 ? 421 ALA A C   1 
ATOM   455  O O   . ALA A 1 69  ? -8.65792  -18.12026 28.73324  1.000 31.28656 ? 421 ALA A O   1 
ATOM   456  C CB  . ALA A 1 69  ? -11.46613 -17.01441 30.08734  1.000 37.91140 ? 421 ALA A CB  1 
ATOM   457  N N   . ASN A 1 70  ? -10.46636 -18.38999 27.41006  1.000 36.23025 ? 422 ASN A N   1 
ATOM   458  C CA  . ASN A 1 70  ? -9.91512  -19.55911 26.72414  1.000 35.81253 ? 422 ASN A CA  1 
ATOM   459  C C   . ASN A 1 70  ? -8.58888  -19.23690 26.03938  1.000 34.62545 ? 422 ASN A C   1 
ATOM   460  O O   . ASN A 1 70  ? -7.68275  -20.08327 25.98043  1.000 39.72638 ? 422 ASN A O   1 
ATOM   461  C CB  . ASN A 1 70  ? -10.93457 -20.07511 25.70426  1.000 41.00885 ? 422 ASN A CB  1 
ATOM   462  C CG  . ASN A 1 70  ? -10.37219 -21.17356 24.79917  1.000 52.45573 ? 422 ASN A CG  1 
ATOM   463  O OD1 . ASN A 1 70  ? -10.34732 -22.34111 25.18057  1.000 51.16595 ? 422 ASN A OD1 1 
ATOM   464  N ND2 . ASN A 1 70  ? -9.94027  -20.80107 23.58724  1.000 42.02694 ? 422 ASN A ND2 1 
ATOM   465  N N   . VAL A 1 71  ? -8.45604  -18.01577 25.51847  1.000 31.51649 ? 423 VAL A N   1 
ATOM   466  C CA  . VAL A 1 71  ? -7.22659  -17.61458 24.84501  1.000 31.02424 ? 423 VAL A CA  1 
ATOM   467  C C   . VAL A 1 71  ? -6.14248  -17.31319 25.86915  1.000 29.56994 ? 423 VAL A C   1 
ATOM   468  O O   . VAL A 1 71  ? -4.98909  -17.72962 25.71896  1.000 32.98941 ? 423 VAL A O   1 
ATOM   469  C CB  . VAL A 1 71  ? -7.48039  -16.39663 23.93350  1.000 31.33284 ? 423 VAL A CB  1 
ATOM   470  C CG1 . VAL A 1 71  ? -6.15426  -15.85631 23.38292  1.000 33.77189 ? 423 VAL A CG1 1 
ATOM   471  C CG2 . VAL A 1 71  ? -8.42109  -16.75509 22.79053  1.000 29.38580 ? 423 VAL A CG2 1 
ATOM   472  N N   . MET A 1 72  ? -6.48445  -16.54264 26.90370  1.000 30.35755 ? 424 MET A N   1 
ATOM   473  C CA  . MET A 1 72  ? -5.47829  -16.17343 27.89450  1.000 33.14996 ? 424 MET A CA  1 
ATOM   474  C C   . MET A 1 72  ? -4.94584  -17.39495 28.63433  1.000 36.80905 ? 424 MET A C   1 
ATOM   475  O O   . MET A 1 72  ? -3.76665  -17.42432 29.00838  1.000 36.62216 ? 424 MET A O   1 
ATOM   476  C CB  . MET A 1 72  ? -6.04945  -15.17061 28.88902  1.000 29.69766 ? 424 MET A CB  1 
ATOM   477  C CG  . MET A 1 72  ? -6.55434  -13.88453 28.26634  1.000 28.74084 ? 424 MET A CG  1 
ATOM   478  S SD  . MET A 1 72  ? -7.03628  -12.66885 29.52521  1.000 33.64233 ? 424 MET A SD  1 
ATOM   479  C CE  . MET A 1 72  ? -5.46529  -11.92151 29.99251  1.000 26.56682 ? 424 MET A CE  1 
ATOM   480  N N   . GLN A 1 73  ? -5.79658  -18.40293 28.85111  1.000 30.22567 ? 425 GLN A N   1 
ATOM   481  C CA  . GLN A 1 73  ? -5.36486  -19.62898 29.51702  1.000 38.21088 ? 425 GLN A CA  1 
ATOM   482  C C   . GLN A 1 73  ? -4.23258  -20.31852 28.76202  1.000 41.13193 ? 425 GLN A C   1 
ATOM   483  O O   . GLN A 1 73  ? -3.43277  -21.04022 29.36940  1.000 37.25018 ? 425 GLN A O   1 
ATOM   484  C CB  . GLN A 1 73  ? -6.55934  -20.57730 29.67680  1.000 42.01786 ? 425 GLN A CB  1 
ATOM   485  C CG  . GLN A 1 73  ? -6.21732  -21.99478 30.13345  1.000 56.76021 ? 425 GLN A CG  1 
ATOM   486  C CD  . GLN A 1 73  ? -5.33988  -22.02360 31.37715  1.000 69.69521 ? 425 GLN A CD  1 
ATOM   487  O OE1 . GLN A 1 73  ? -4.36202  -22.77231 31.44023  1.000 77.21953 ? 425 GLN A OE1 1 
ATOM   488  N NE2 . GLN A 1 73  ? -5.68254  -21.20677 32.37125  1.000 74.77291 ? 425 GLN A NE2 1 
ATOM   489  N N   . GLN A 1 74  ? -4.13600  -20.10651 27.44921  1.000 39.35458 ? 426 GLN A N   1 
ATOM   490  C CA  . GLN A 1 74  ? -3.11121  -20.76113 26.64096  1.000 40.06506 ? 426 GLN A CA  1 
ATOM   491  C C   . GLN A 1 74  ? -1.81816  -19.96326 26.52224  1.000 40.48414 ? 426 GLN A C   1 
ATOM   492  O O   . GLN A 1 74  ? -0.81328  -20.51254 26.05527  1.000 37.60156 ? 426 GLN A O   1 
ATOM   493  C CB  . GLN A 1 74  ? -3.64422  -21.03630 25.23479  1.000 36.01475 ? 426 GLN A CB  1 
ATOM   494  C CG  . GLN A 1 74  ? -4.96449  -21.79092 25.21977  1.000 39.74237 ? 426 GLN A CG  1 
ATOM   495  C CD  . GLN A 1 74  ? -5.54990  -21.88974 23.82969  1.000 43.60358 ? 426 GLN A CD  1 
ATOM   496  O OE1 . GLN A 1 74  ? -4.95621  -22.49736 22.92791  1.000 35.60947 ? 426 GLN A OE1 1 
ATOM   497  N NE2 . GLN A 1 74  ? -6.72841  -21.29949 23.64570  1.000 37.54026 ? 426 GLN A NE2 1 
ATOM   498  N N   . LEU A 1 75  ? -1.81125  -18.69270 26.91376  1.000 37.98733 ? 427 LEU A N   1 
ATOM   499  C CA  . LEU A 1 75  ? -0.66926  -17.82341 26.67816  1.000 32.52786 ? 427 LEU A CA  1 
ATOM   500  C C   . LEU A 1 75  ? 0.18231   -17.71677 27.93120  1.000 35.58199 ? 427 LEU A C   1 
ATOM   501  O O   . LEU A 1 75  ? -0.33731  -17.63223 29.05009  1.000 33.94816 ? 427 LEU A O   1 
ATOM   502  C CB  . LEU A 1 75  ? -1.12070  -16.43010 26.22887  1.000 36.45730 ? 427 LEU A CB  1 
ATOM   503  C CG  . LEU A 1 75  ? -2.03416  -16.45022 24.99028  1.000 33.14511 ? 427 LEU A CG  1 
ATOM   504  C CD1 . LEU A 1 75  ? -2.65357  -15.07503 24.73389  1.000 36.99435 ? 427 LEU A CD1 1 
ATOM   505  C CD2 . LEU A 1 75  ? -1.28236  -16.95182 23.74978  1.000 32.04092 ? 427 LEU A CD2 1 
ATOM   506  N N   . ASP A 1 76  ? 1.49938   -17.70892 27.73159  1.000 38.66485 ? 428 ASP A N   1 
ATOM   507  C CA  . ASP A 1 76  ? 2.44713   -17.58611 28.83877  1.000 37.76638 ? 428 ASP A CA  1 
ATOM   508  C C   . ASP A 1 76  ? 3.63839   -16.79832 28.30649  1.000 37.42350 ? 428 ASP A C   1 
ATOM   509  O O   . ASP A 1 76  ? 4.46940   -17.35669 27.58788  1.000 38.57245 ? 428 ASP A O   1 
ATOM   510  C CB  . ASP A 1 76  ? 2.86872   -18.95491 29.36001  1.000 40.22325 ? 428 ASP A CB  1 
ATOM   511  C CG  . ASP A 1 76  ? 3.61618   -18.86583 30.67562  1.000 51.01042 ? 428 ASP A CG  1 
ATOM   512  O OD1 . ASP A 1 76  ? 3.87312   -17.73009 31.12813  1.000 44.22475 ? 428 ASP A OD1 1 
ATOM   513  O OD2 . ASP A 1 76  ? 3.92611   -19.92179 31.26310  1.000 52.81585 ? 428 ASP A OD2 1 
ATOM   514  N N   . ASN A 1 77  ? 3.70096   -15.50573 28.64546  1.000 38.65365 ? 429 ASN A N   1 
ATOM   515  C CA  . ASN A 1 77  ? 4.73814   -14.63007 28.12354  1.000 36.40433 ? 429 ASN A CA  1 
ATOM   516  C C   . ASN A 1 77  ? 4.81302   -13.40155 29.00836  1.000 37.44894 ? 429 ASN A C   1 
ATOM   517  O O   . ASN A 1 77  ? 3.76040   -12.90967 29.44404  1.000 31.73514 ? 429 ASN A O   1 
ATOM   518  C CB  . ASN A 1 77  ? 4.44298   -14.22154 26.67567  1.000 34.45077 ? 429 ASN A CB  1 
ATOM   519  C CG  . ASN A 1 77  ? 5.50955   -13.31152 26.10091  1.000 38.76668 ? 429 ASN A CG  1 
ATOM   520  O OD1 . ASN A 1 77  ? 5.39599   -12.07980 26.16769  1.000 31.98886 ? 429 ASN A OD1 1 
ATOM   521  N ND2 . ASN A 1 77  ? 6.56192   -13.91157 25.53790  1.000 31.24173 ? 429 ASN A ND2 1 
ATOM   522  N N   . PRO A 1 78  ? 6.01269   -12.86730 29.27825  1.000 27.95902 ? 430 PRO A N   1 
ATOM   523  C CA  . PRO A 1 78  ? 6.12784   -11.73677 30.21700  1.000 34.11508 ? 430 PRO A CA  1 
ATOM   524  C C   . PRO A 1 78  ? 5.43173   -10.46577 29.76801  1.000 29.80652 ? 430 PRO A C   1 
ATOM   525  O O   . PRO A 1 78  ? 5.20260   -9.57780  30.59616  1.000 29.32800 ? 430 PRO A O   1 
ATOM   526  C CB  . PRO A 1 78  ? 7.64689   -11.51122 30.31501  1.000 36.91102 ? 430 PRO A CB  1 
ATOM   527  C CG  . PRO A 1 78  ? 8.28532   -12.70567 29.74122  1.000 34.56984 ? 430 PRO A CG  1 
ATOM   528  C CD  . PRO A 1 78  ? 7.32530   -13.30118 28.76574  1.000 36.66934 ? 430 PRO A CD  1 
ATOM   529  N N   . TYR A 1 79  ? 5.10001   -10.33189 28.48887  1.000 30.62357 ? 431 TYR A N   1 
ATOM   530  C CA  . TYR A 1 79  ? 4.50924   -9.10351  27.98354  1.000 29.53943 ? 431 TYR A CA  1 
ATOM   531  C C   . TYR A 1 79  ? 3.04091   -9.28910  27.61968  1.000 31.79451 ? 431 TYR A C   1 
ATOM   532  O O   . TYR A 1 79  ? 2.49954   -8.51345  26.82263  1.000 26.99934 ? 431 TYR A O   1 
ATOM   533  C CB  . TYR A 1 79  ? 5.31314   -8.60288  26.78922  1.000 31.14135 ? 431 TYR A CB  1 
ATOM   534  C CG  . TYR A 1 79  ? 6.79239   -8.55476  27.10848  1.000 31.76980 ? 431 TYR A CG  1 
ATOM   535  C CD1 . TYR A 1 79  ? 7.31185   -7.57307  27.93954  1.000 30.90197 ? 431 TYR A CD1 1 
ATOM   536  C CD2 . TYR A 1 79  ? 7.65171   -9.52081  26.61484  1.000 34.58416 ? 431 TYR A CD2 1 
ATOM   537  C CE1 . TYR A 1 79  ? 8.68611   -7.54441  28.25178  1.000 33.88321 ? 431 TYR A CE1 1 
ATOM   538  C CE2 . TYR A 1 79  ? 9.01104   -9.50278  26.91390  1.000 30.10729 ? 431 TYR A CE2 1 
ATOM   539  C CZ  . TYR A 1 79  ? 9.51483   -8.52472  27.72480  1.000 34.35846 ? 431 TYR A CZ  1 
ATOM   540  O OH  . TYR A 1 79  ? 10.86968  -8.54628  27.99451  1.000 38.03761 ? 431 TYR A OH  1 
ATOM   541  N N   . ILE A 1 80  ? 2.41166   -10.32662 28.17218  1.000 27.17892 ? 432 ILE A N   1 
ATOM   542  C CA  . ILE A 1 80  ? 0.97491   -10.58265 28.07705  1.000 28.64111 ? 432 ILE A CA  1 
ATOM   543  C C   . ILE A 1 80  ? 0.42780   -10.62926 29.49916  1.000 31.58300 ? 432 ILE A C   1 
ATOM   544  O O   . ILE A 1 80  ? 1.04988   -11.22628 30.38977  1.000 31.12740 ? 432 ILE A O   1 
ATOM   545  C CB  . ILE A 1 80  ? 0.69744   -11.91646 27.33280  1.000 27.00285 ? 432 ILE A CB  1 
ATOM   546  C CG1 . ILE A 1 80  ? 1.35551   -11.94591 25.94500  1.000 27.82323 ? 432 ILE A CG1 1 
ATOM   547  C CG2 . ILE A 1 80  ? -0.81054  -12.23928 27.23824  1.000 25.48565 ? 432 ILE A CG2 1 
ATOM   548  C CD1 . ILE A 1 80  ? 0.77398   -10.99573 24.97197  1.000 35.48359 ? 432 ILE A CD1 1 
ATOM   549  N N   . VAL A 1 81  ? -0.72741  -9.99308  29.72082  1.000 27.48900 ? 433 VAL A N   1 
ATOM   550  C CA  . VAL A 1 81  ? -1.38994  -10.07409 31.02397  1.000 26.95557 ? 433 VAL A CA  1 
ATOM   551  C C   . VAL A 1 81  ? -1.76900  -11.51929 31.34258  1.000 33.09849 ? 433 VAL A C   1 
ATOM   552  O O   . VAL A 1 81  ? -2.34138  -12.24141 30.50749  1.000 27.19711 ? 433 VAL A O   1 
ATOM   553  C CB  . VAL A 1 81  ? -2.61783  -9.15004  31.03806  1.000 31.68709 ? 433 VAL A CB  1 
ATOM   554  C CG1 . VAL A 1 81  ? -3.43171  -9.30132  32.32837  1.000 32.30661 ? 433 VAL A CG1 1 
ATOM   555  C CG2 . VAL A 1 81  ? -2.18489  -7.69610  30.85730  1.000 30.61509 ? 433 VAL A CG2 1 
ATOM   556  N N   . ARG A 1 82  ? -1.47939  -11.94008 32.57384  1.000 32.62864 ? 434 ARG A N   1 
ATOM   557  C CA  . ARG A 1 82  ? -1.79196  -13.28750 33.02555  1.000 29.07791 ? 434 ARG A CA  1 
ATOM   558  C C   . ARG A 1 82  ? -3.20917  -13.32610 33.58157  1.000 32.13482 ? 434 ARG A C   1 
ATOM   559  O O   . ARG A 1 82  ? -3.61825  -12.44801 34.34385  1.000 28.50250 ? 434 ARG A O   1 
ATOM   560  C CB  . ARG A 1 82  ? -0.82087  -13.76489 34.11227  1.000 31.89912 ? 434 ARG A CB  1 
ATOM   561  C CG  . ARG A 1 82  ? 0.63044   -13.28505 33.99092  1.000 48.34677 ? 434 ARG A CG  1 
ATOM   562  C CD  . ARG A 1 82  ? 1.48761   -14.06451 33.00236  1.000 57.77899 ? 434 ARG A CD  1 
ATOM   563  N NE  . ARG A 1 82  ? 2.88147   -13.61924 33.05035  1.000 53.63618 ? 434 ARG A NE  1 
ATOM   564  C CZ  . ARG A 1 82  ? 3.89054   -14.24607 32.45977  1.000 62.68649 ? 434 ARG A CZ  1 
ATOM   565  N NH1 . ARG A 1 82  ? 3.69204   -15.32604 31.71599  1.000 58.06229 ? 434 ARG A NH1 1 
ATOM   566  N NH2 . ARG A 1 82  ? 5.13165   -13.78856 32.63110  1.000 52.18565 ? 434 ARG A NH2 1 
ATOM   567  N N   . MET A 1 83  ? -3.94693  -14.35588 33.21796  1.000 23.74208 ? 435 MET A N   1 
ATOM   568  C CA  . MET A 1 83  ? -5.27223  -14.55306 33.77644  1.000 29.32261 ? 435 MET A CA  1 
ATOM   569  C C   . MET A 1 83  ? -5.15553  -15.43125 35.01380  1.000 30.75123 ? 435 MET A C   1 
ATOM   570  O O   . MET A 1 83  ? -4.49203  -16.47414 34.97226  1.000 29.60460 ? 435 MET A O   1 
ATOM   571  C CB  . MET A 1 83  ? -6.18622  -15.20814 32.74974  1.000 28.47435 ? 435 MET A CB  1 
ATOM   572  C CG  . MET A 1 83  ? -7.57695  -15.52238 33.30524  1.000 35.31563 ? 435 MET A CG  1 
ATOM   573  S SD  . MET A 1 83  ? -8.60994  -16.40004 32.12393  1.000 45.01159 ? 435 MET A SD  1 
ATOM   574  C CE  . MET A 1 83  ? -7.76319  -17.97734 32.00028  1.000 35.48196 ? 435 MET A CE  1 
ATOM   575  N N   . ILE A 1 84  ? -5.77897  -15.00261 36.11391  1.000 28.24754 ? 436 ILE A N   1 
ATOM   576  C CA  . ILE A 1 84  ? -5.86276  -15.86575 37.29477  1.000 28.85603 ? 436 ILE A CA  1 
ATOM   577  C C   . ILE A 1 84  ? -6.96807  -16.89136 37.10902  1.000 37.03824 ? 436 ILE A C   1 
ATOM   578  O O   . ILE A 1 84  ? -6.78448  -18.08318 37.37220  1.000 36.28532 ? 436 ILE A O   1 
ATOM   579  C CB  . ILE A 1 84  ? -6.10712  -15.05440 38.58317  1.000 27.87377 ? 436 ILE A CB  1 
ATOM   580  C CG1 . ILE A 1 84  ? -5.01409  -13.99996 38.81521  1.000 36.34528 ? 436 ILE A CG1 1 
ATOM   581  C CG2 . ILE A 1 84  ? -6.22458  -16.02049 39.79587  1.000 26.62117 ? 436 ILE A CG2 1 
ATOM   582  C CD1 . ILE A 1 84  ? -3.62725  -14.53897 38.74733  1.000 30.91021 ? 436 ILE A CD1 1 
ATOM   583  N N   . GLY A 1 85  ? -8.13831  -16.42458 36.67839  1.000 39.03837 ? 437 GLY A N   1 
ATOM   584  C CA  . GLY A 1 85  ? -9.25434  -17.30660 36.42357  1.000 33.18350 ? 437 GLY A CA  1 
ATOM   585  C C   . GLY A 1 85  ? -10.52795 -16.52259 36.16865  1.000 37.85722 ? 437 GLY A C   1 
ATOM   586  O O   . GLY A 1 85  ? -10.52191 -15.29346 36.00004  1.000 33.15755 ? 437 GLY A O   1 
ATOM   587  N N   . ILE A 1 86  ? -11.61913 -17.27163 36.13653  1.000 30.15030 ? 438 ILE A N   1 
ATOM   588  C CA  . ILE A 1 86  ? -12.94235 -16.73495 35.87225  1.000 37.88212 ? 438 ILE A CA  1 
ATOM   589  C C   . ILE A 1 86  ? -13.81690 -17.07290 37.07032  1.000 40.68939 ? 438 ILE A C   1 
ATOM   590  O O   . ILE A 1 86  ? -13.64075 -18.12376 37.69719  1.000 36.60679 ? 438 ILE A O   1 
ATOM   591  C CB  . ILE A 1 86  ? -13.50375 -17.31567 34.55686  1.000 44.76379 ? 438 ILE A CB  1 
ATOM   592  C CG1 . ILE A 1 86  ? -14.87643 -16.75130 34.22813  1.000 50.90822 ? 438 ILE A CG1 1 
ATOM   593  C CG2 . ILE A 1 86  ? -13.56487 -18.83240 34.63112  1.000 51.27681 ? 438 ILE A CG2 1 
ATOM   594  C CD1 . ILE A 1 86  ? -15.52850 -17.47575 33.06797  1.000 59.34304 ? 438 ILE A CD1 1 
ATOM   595  N N   . CYS A 1 87  ? -14.72648 -16.16488 37.41949  1.000 34.20248 ? 439 CYS A N   1 
ATOM   596  C CA  . CYS A 1 87  ? -15.59866 -16.36595 38.56713  1.000 46.81220 ? 439 CYS A CA  1 
ATOM   597  C C   . CYS A 1 87  ? -17.03585 -16.06269 38.17123  1.000 39.85817 ? 439 CYS A C   1 
ATOM   598  O O   . CYS A 1 87  ? -17.31639 -15.00219 37.59959  1.000 39.94175 ? 439 CYS A O   1 
ATOM   599  C CB  . CYS A 1 87  ? -15.15751 -15.48943 39.74473  1.000 42.57609 ? 439 CYS A CB  1 
ATOM   600  S SG  . CYS A 1 87  ? -15.92525 -15.88937 41.32673  1.000 47.41723 ? 439 CYS A SG  1 
ATOM   601  N N   . GLU A 1 88  ? -17.93477 -17.00503 38.47013  1.000 43.61493 ? 440 GLU A N   1 
ATOM   602  C CA  . GLU A 1 88  ? -19.37295 -16.88155 38.23390  1.000 44.53989 ? 440 GLU A CA  1 
ATOM   603  C C   . GLU A 1 88  ? -20.05979 -16.69503 39.58497  1.000 43.82864 ? 440 GLU A C   1 
ATOM   604  O O   . GLU A 1 88  ? -20.20711 -17.65004 40.35120  1.000 50.91647 ? 440 GLU A O   1 
ATOM   605  C CB  . GLU A 1 88  ? -19.90123 -18.11471 37.50378  1.000 49.71248 ? 440 GLU A CB  1 
ATOM   606  C CG  . GLU A 1 88  ? -21.41327 -18.29463 37.55737  1.000 58.34725 ? 440 GLU A CG  1 
ATOM   607  C CD  . GLU A 1 88  ? -21.84516 -19.70355 37.15854  1.000 77.51300 ? 440 GLU A CD  1 
ATOM   608  O OE1 . GLU A 1 88  ? -20.98888 -20.48235 36.66970  1.000 68.87264 ? 440 GLU A OE1 1 
ATOM   609  O OE2 . GLU A 1 88  ? -23.04032 -20.03361 37.34335  1.000 76.79467 ? 440 GLU A OE2 1 
ATOM   610  N N   . ALA A 1 89  ? -20.46701 -15.46029 39.87681  1.000 50.52344 ? 441 ALA A N   1 
ATOM   611  C CA  . ALA A 1 89  ? -21.17762 -15.12315 41.10763  1.000 47.87327 ? 441 ALA A CA  1 
ATOM   612  C C   . ALA A 1 89  ? -21.60175 -13.66375 41.06228  1.000 54.95094 ? 441 ALA A C   1 
ATOM   613  O O   . ALA A 1 89  ? -20.74592 -12.78479 40.95507  1.000 70.33100 ? 441 ALA A O   1 
ATOM   614  C CB  . ALA A 1 89  ? -20.30566 -15.37479 42.33944  1.000 57.25804 ? 441 ALA A CB  1 
ATOM   615  N N   . GLU A 1 90  ? -22.90783 -13.40242 41.12423  1.000 54.74605 ? 442 GLU A N   1 
ATOM   616  C CA  . GLU A 1 90  ? -23.53062 -12.08417 40.96168  1.000 53.95407 ? 442 GLU A CA  1 
ATOM   617  C C   . GLU A 1 90  ? -23.35259 -11.53654 39.54111  1.000 53.48012 ? 442 GLU A C   1 
ATOM   618  O O   . GLU A 1 90  ? -24.23759 -10.84154 39.02956  1.000 46.53628 ? 442 GLU A O   1 
ATOM   619  C CB  . GLU A 1 90  ? -23.04595 -11.09947 42.04965  1.000 48.23837 ? 442 GLU A CB  1 
ATOM   620  C CG  . GLU A 1 90  ? -21.85382 -10.17913 41.77039  1.000 52.85054 ? 442 GLU A CG  1 
ATOM   621  C CD  . GLU A 1 90  ? -20.78373 -10.29175 42.86189  1.000 44.22373 ? 442 GLU A CD  1 
ATOM   622  O OE1 . GLU A 1 90  ? -20.41510 -11.43578 43.21662  1.000 42.67043 ? 442 GLU A OE1 1 
ATOM   623  O OE2 . GLU A 1 90  ? -20.32611 -9.24744  43.37766  1.000 41.09436 ? 442 GLU A OE2 1 
ATOM   624  N N   . SER A 1 91  ? -22.23848 -11.86182 38.88702  1.000 47.56459 ? 443 SER A N   1 
ATOM   625  C CA  . SER A 1 91  ? -22.07819 -11.71176 37.44381  1.000 40.88849 ? 443 SER A CA  1 
ATOM   626  C C   . SER A 1 91  ? -20.84920 -12.52183 37.06047  1.000 45.16976 ? 443 SER A C   1 
ATOM   627  O O   . SER A 1 91  ? -20.15929 -13.07350 37.92040  1.000 41.44651 ? 443 SER A O   1 
ATOM   628  C CB  . SER A 1 91  ? -21.94859 -10.23781 37.01512  1.000 39.70132 ? 443 SER A CB  1 
ATOM   629  O OG  . SER A 1 91  ? -21.90900 -10.09269 35.59419  1.000 40.35281 ? 443 SER A OG  1 
ATOM   630  N N   . TRP A 1 92  ? -20.58943 -12.61029 35.76064  1.000 37.89396 ? 444 TRP A N   1 
ATOM   631  C CA  . TRP A 1 92  ? -19.39288 -13.30063 35.30196  1.000 40.61793 ? 444 TRP A CA  1 
ATOM   632  C C   . TRP A 1 92  ? -18.20576 -12.34708 35.37117  1.000 35.85707 ? 444 TRP A C   1 
ATOM   633  O O   . TRP A 1 92  ? -18.31467 -11.18130 34.97427  1.000 34.79091 ? 444 TRP A O   1 
ATOM   634  C CB  . TRP A 1 92  ? -19.58787 -13.83609 33.88148  1.000 36.77947 ? 444 TRP A CB  1 
ATOM   635  C CG  . TRP A 1 92  ? -20.48304 -15.05801 33.81948  1.000 52.62392 ? 444 TRP A CG  1 
ATOM   636  C CD1 . TRP A 1 92  ? -21.83765 -15.07094 33.67027  1.000 58.04850 ? 444 TRP A CD1 1 
ATOM   637  C CD2 . TRP A 1 92  ? -20.08186 -16.43599 33.92223  1.000 63.63824 ? 444 TRP A CD2 1 
ATOM   638  N NE1 . TRP A 1 92  ? -22.30497 -16.36262 33.66725  1.000 50.09595 ? 444 TRP A NE1 1 
ATOM   639  C CE2 . TRP A 1 92  ? -21.25064 -17.22078 33.81688  1.000 55.60804 ? 444 TRP A CE2 1 
ATOM   640  C CE3 . TRP A 1 92  ? -18.85152 -17.08096 34.09264  1.000 62.18329 ? 444 TRP A CE3 1 
ATOM   641  C CZ2 . TRP A 1 92  ? -21.22711 -18.61619 33.87823  1.000 57.27037 ? 444 TRP A CZ2 1 
ATOM   642  C CZ3 . TRP A 1 92  ? -18.82977 -18.47569 34.14669  1.000 65.22359 ? 444 TRP A CZ3 1 
ATOM   643  C CH2 . TRP A 1 92  ? -20.01231 -19.22390 34.04328  1.000 50.21816 ? 444 TRP A CH2 1 
ATOM   644  N N   . MET A 1 93  ? -17.07771 -12.83650 35.89082  1.000 36.30854 ? 445 MET A N   1 
ATOM   645  C CA  . MET A 1 93  ? -15.90223 -12.00769 36.12571  1.000 33.12234 ? 445 MET A CA  1 
ATOM   646  C C   . MET A 1 93  ? -14.65105 -12.70542 35.61863  1.000 38.34914 ? 445 MET A C   1 
ATOM   647  O O   . MET A 1 93  ? -14.48799 -13.91530 35.79242  1.000 33.93335 ? 445 MET A O   1 
ATOM   648  C CB  . MET A 1 93  ? -15.69187 -11.69681 37.60674  1.000 40.27735 ? 445 MET A CB  1 
ATOM   649  C CG  . MET A 1 93  ? -16.82588 -10.98033 38.34771  1.000 37.82033 ? 445 MET A CG  1 
ATOM   650  S SD  . MET A 1 93  ? -16.54830 -11.21061 40.13032  1.000 41.83461 ? 445 MET A SD  1 
ATOM   651  C CE  . MET A 1 93  ? -15.01517 -12.10942 40.08836  1.000 64.28322 ? 445 MET A CE  1 
ATOM   652  N N   . LEU A 1 94  ? -13.75578 -11.92119 35.02891  1.000 28.65591 ? 446 LEU A N   1 
ATOM   653  C CA  . LEU A 1 94  ? -12.46262 -12.38968 34.54635  1.000 33.47660 ? 446 LEU A CA  1 
ATOM   654  C C   . LEU A 1 94  ? -11.38297 -11.80010 35.44502  1.000 28.65069 ? 446 LEU A C   1 
ATOM   655  O O   . LEU A 1 94  ? -11.22502 -10.57511 35.49263  1.000 30.38140 ? 446 LEU A O   1 
ATOM   656  C CB  . LEU A 1 94  ? -12.25477 -11.96212 33.09215  1.000 35.18074 ? 446 LEU A CB  1 
ATOM   657  C CG  . LEU A 1 94  ? -10.91707 -12.28164 32.43154  1.000 34.56187 ? 446 LEU A CG  1 
ATOM   658  C CD1 . LEU A 1 94  ? -10.68681 -13.76827 32.48158  1.000 33.57549 ? 446 LEU A CD1 1 
ATOM   659  C CD2 . LEU A 1 94  ? -10.93275 -11.79527 31.00457  1.000 39.14966 ? 446 LEU A CD2 1 
ATOM   660  N N   . VAL A 1 95  ? -10.65371 -12.65832 36.15639  1.000 28.45666 ? 447 VAL A N   1 
ATOM   661  C CA  . VAL A 1 95  ? -9.69432  -12.22410 37.17119  1.000 28.94993 ? 447 VAL A CA  1 
ATOM   662  C C   . VAL A 1 95  ? -8.29042  -12.27131 36.57915  1.000 26.40004 ? 447 VAL A C   1 
ATOM   663  O O   . VAL A 1 95  ? -7.80946  -13.33381 36.16497  1.000 25.87719 ? 447 VAL A O   1 
ATOM   664  C CB  . VAL A 1 95  ? -9.77688  -13.08569 38.44177  1.000 30.37029 ? 447 VAL A CB  1 
ATOM   665  C CG1 . VAL A 1 95  ? -8.80483  -12.56360 39.49808  1.000 27.57278 ? 447 VAL A CG1 1 
ATOM   666  C CG2 . VAL A 1 95  ? -11.20698 -13.14747 38.98810  1.000 26.40782 ? 447 VAL A CG2 1 
ATOM   667  N N   . MET A 1 96  ? -7.61775  -11.13001 36.56514  1.000 23.45784 ? 448 MET A N   1 
ATOM   668  C CA  . MET A 1 96  ? -6.28404  -11.04413 35.97988  1.000 29.46751 ? 448 MET A CA  1 
ATOM   669  C C   . MET A 1 96  ? -5.29349  -10.48938 36.99832  1.000 28.22171 ? 448 MET A C   1 
ATOM   670  O O   . MET A 1 96  ? -5.66510  -9.75496  37.91697  1.000 29.71056 ? 448 MET A O   1 
ATOM   671  C CB  . MET A 1 96  ? -6.30689  -10.15584 34.72024  1.000 31.59518 ? 448 MET A CB  1 
ATOM   672  C CG  . MET A 1 96  ? -7.06849  -10.75740 33.53811  1.000 33.28507 ? 448 MET A CG  1 
ATOM   673  S SD  . MET A 1 96  ? -7.60866  -9.47155  32.39633  1.000 31.50250 ? 448 MET A SD  1 
ATOM   674  C CE  . MET A 1 96  ? -8.97000  -8.74215  33.30837  1.000 31.69844 ? 448 MET A CE  1 
ATOM   675  N N   . GLU A 1 97  ? -4.01533  -10.81013 36.80930  1.000 24.81720 ? 449 GLU A N   1 
ATOM   676  C CA  . GLU A 1 97  ? -2.97417  -10.15992 37.60388  1.000 23.59554 ? 449 GLU A CA  1 
ATOM   677  C C   . GLU A 1 97  ? -2.97572  -8.65830  37.34757  1.000 26.31753 ? 449 GLU A C   1 
ATOM   678  O O   . GLU A 1 97  ? -2.97918  -8.20854  36.19832  1.000 26.91006 ? 449 GLU A O   1 
ATOM   679  C CB  . GLU A 1 97  ? -1.59921  -10.74050 37.27891  1.000 29.85926 ? 449 GLU A CB  1 
ATOM   680  C CG  . GLU A 1 97  ? -0.41035  -9.91684  37.82281  1.000 28.97768 ? 449 GLU A CG  1 
ATOM   681  C CD  . GLU A 1 97  ? 0.94295   -10.50498 37.42004  1.000 40.91938 ? 449 GLU A CD  1 
ATOM   682  O OE1 . GLU A 1 97  ? 1.05458   -11.00994 36.27913  1.000 34.05204 ? 449 GLU A OE1 1 
ATOM   683  O OE2 . GLU A 1 97  ? 1.88942   -10.46605 38.25046  1.000 45.01126 ? 449 GLU A OE2 1 
ATOM   684  N N   . MET A 1 98  ? -2.96169  -7.88626  38.42948  1.000 23.49502 ? 450 MET A N   1 
ATOM   685  C CA  . MET A 1 98  ? -3.09369  -6.43902  38.33307  1.000 25.38305 ? 450 MET A CA  1 
ATOM   686  C C   . MET A 1 98  ? -1.85926  -5.81305  37.69564  1.000 30.02727 ? 450 MET A C   1 
ATOM   687  O O   . MET A 1 98  ? -0.73314  -6.04602  38.14490  1.000 30.77316 ? 450 MET A O   1 
ATOM   688  C CB  . MET A 1 98  ? -3.32226  -5.85302  39.72784  1.000 26.25438 ? 450 MET A CB  1 
ATOM   689  C CG  . MET A 1 98  ? -3.11176  -4.35178  39.79624  1.000 31.32982 ? 450 MET A CG  1 
ATOM   690  S SD  . MET A 1 98  ? -4.25772  -3.45750  38.75118  1.000 36.11453 ? 450 MET A SD  1 
ATOM   691  C CE  . MET A 1 98  ? -5.74209  -3.56046  39.75790  1.000 29.19245 ? 450 MET A CE  1 
ATOM   692  N N   . ALA A 1 99  ? -2.07134  -5.02620  36.63546  1.000 26.70887 ? 451 ALA A N   1 
ATOM   693  C CA  . ALA A 1 99  ? -1.05000  -4.12795  36.09279  1.000 32.28213 ? 451 ALA A CA  1 
ATOM   694  C C   . ALA A 1 99  ? -1.39937  -2.73347  36.61158  1.000 35.19332 ? 451 ALA A C   1 
ATOM   695  O O   . ALA A 1 99  ? -2.35342  -2.10361  36.13623  1.000 31.99973 ? 451 ALA A O   1 
ATOM   696  C CB  . ALA A 1 99  ? -1.01564  -4.18357  34.56935  1.000 32.33831 ? 451 ALA A CB  1 
ATOM   697  N N   . GLU A 1 100 ? -0.61740  -2.25185  37.58973  1.000 32.68041 ? 452 GLU A N   1 
ATOM   698  C CA  . GLU A 1 100 ? -1.08829  -1.19148  38.48245  1.000 28.35308 ? 452 GLU A CA  1 
ATOM   699  C C   . GLU A 1 100 ? -1.32770  0.13481   37.75851  1.000 37.43534 ? 452 GLU A C   1 
ATOM   700  O O   . GLU A 1 100 ? -2.25947  0.87507   38.09934  1.000 33.69452 ? 452 GLU A O   1 
ATOM   701  C CB  . GLU A 1 100 ? -0.10179  -1.00626  39.64102  1.000 37.20481 ? 452 GLU A CB  1 
ATOM   702  C CG  . GLU A 1 100 ? -0.01863  -2.21892  40.59805  1.000 51.65340 ? 452 GLU A CG  1 
ATOM   703  C CD  . GLU A 1 100 ? -1.01337  -2.18062  41.75700  1.000 61.20982 ? 452 GLU A CD  1 
ATOM   704  O OE1 . GLU A 1 100 ? -1.79321  -1.20548  41.81967  1.000 47.98637 ? 452 GLU A OE1 1 
ATOM   705  O OE2 . GLU A 1 100 ? -0.99738  -3.12302  42.60197  1.000 44.61345 ? 452 GLU A OE2 1 
ATOM   706  N N   . LEU A 1 101 ? -0.50892  0.46701   36.76662  1.000 32.65536 ? 453 LEU A N   1 
ATOM   707  C CA  . LEU A 1 101 ? -0.61373  1.80194   36.17769  1.000 30.89395 ? 453 LEU A CA  1 
ATOM   708  C C   . LEU A 1 101 ? -1.72217  1.94175   35.13473  1.000 31.49702 ? 453 LEU A C   1 
ATOM   709  O O   . LEU A 1 101 ? -2.05604  3.06780   34.75737  1.000 32.35053 ? 453 LEU A O   1 
ATOM   710  C CB  . LEU A 1 101 ? 0.72348   2.20279   35.56313  1.000 33.89621 ? 453 LEU A CB  1 
ATOM   711  C CG  . LEU A 1 101 ? 1.82217   2.47381   36.57671  1.000 36.74337 ? 453 LEU A CG  1 
ATOM   712  C CD1 . LEU A 1 101 ? 3.08827   2.89308   35.85530  1.000 40.04146 ? 453 LEU A CD1 1 
ATOM   713  C CD2 . LEU A 1 101 ? 1.36147   3.54745   37.56495  1.000 42.69488 ? 453 LEU A CD2 1 
ATOM   714  N N   . GLY A 1 102 ? -2.28278  0.85252   34.63139  1.000 32.72483 ? 454 GLY A N   1 
ATOM   715  C CA  . GLY A 1 102 ? -3.47297  0.95033   33.80948  1.000 29.04796 ? 454 GLY A CA  1 
ATOM   716  C C   . GLY A 1 102 ? -3.19061  1.13873   32.32798  1.000 29.33003 ? 454 GLY A C   1 
ATOM   717  O O   . GLY A 1 102 ? -2.05316  0.99533   31.86526  1.000 28.66481 ? 454 GLY A O   1 
ATOM   718  N N   . PRO A 1 103 ? -4.23662  1.46166   31.56074  1.000 27.25779 ? 455 PRO A N   1 
ATOM   719  C CA  . PRO A 1 103 ? -4.11049  1.52829   30.09319  1.000 24.75165 ? 455 PRO A CA  1 
ATOM   720  C C   . PRO A 1 103 ? -3.07808  2.54290   29.61744  1.000 36.64751 ? 455 PRO A C   1 
ATOM   721  O O   . PRO A 1 103 ? -2.94598  3.64766   30.16197  1.000 31.99083 ? 455 PRO A O   1 
ATOM   722  C CB  . PRO A 1 103 ? -5.51999  1.91602   29.64019  1.000 29.43108 ? 455 PRO A CB  1 
ATOM   723  C CG  . PRO A 1 103 ? -6.41475  1.39122   30.73537  1.000 29.58908 ? 455 PRO A CG  1 
ATOM   724  C CD  . PRO A 1 103 ? -5.63498  1.60157   32.00053  1.000 30.22094 ? 455 PRO A CD  1 
ATOM   725  N N   . LEU A 1 104 ? -2.35699  2.15332   28.56481  1.000 28.72594 ? 456 LEU A N   1 
ATOM   726  C CA  . LEU A 1 104 ? -1.24903  2.96245   28.07406  1.000 34.81936 ? 456 LEU A CA  1 
ATOM   727  C C   . LEU A 1 104 ? -1.71671  4.33567   27.60811  1.000 31.53261 ? 456 LEU A C   1 
ATOM   728  O O   . LEU A 1 104 ? -1.04070  5.34197   27.85480  1.000 35.31434 ? 456 LEU A O   1 
ATOM   729  C CB  . LEU A 1 104 ? -0.53498  2.23252   26.93277  1.000 33.98747 ? 456 LEU A CB  1 
ATOM   730  C CG  . LEU A 1 104 ? 0.54913   3.01990   26.19070  1.000 31.36876 ? 456 LEU A CG  1 
ATOM   731  C CD1 . LEU A 1 104 ? 1.64756   3.47127   27.15266  1.000 34.65026 ? 456 LEU A CD1 1 
ATOM   732  C CD2 . LEU A 1 104 ? 1.13466   2.19606   25.06405  1.000 36.34444 ? 456 LEU A CD2 1 
ATOM   733  N N   . ASN A 1 105 ? -2.85874  4.40394   26.91167  1.000 35.50713 ? 457 ASN A N   1 
ATOM   734  C CA  . ASN A 1 105 ? -3.27246  5.68678   26.34704  1.000 31.55040 ? 457 ASN A CA  1 
ATOM   735  C C   . ASN A 1 105 ? -3.63740  6.68197   27.44536  1.000 38.35095 ? 457 ASN A C   1 
ATOM   736  O O   . ASN A 1 105 ? -3.23230  7.84808   27.38348  1.000 37.05298 ? 457 ASN A O   1 
ATOM   737  C CB  . ASN A 1 105 ? -4.43538  5.50644   25.36623  1.000 28.97472 ? 457 ASN A CB  1 
ATOM   738  C CG  . ASN A 1 105 ? -5.67549  4.92418   26.01449  1.000 38.37717 ? 457 ASN A CG  1 
ATOM   739  O OD1 . ASN A 1 105 ? -5.58819  4.09073   26.91941  1.000 30.62861 ? 457 ASN A OD1 1 
ATOM   740  N ND2 . ASN A 1 105 ? -6.84483  5.34625   25.53597  1.000 32.77988 ? 457 ASN A ND2 1 
ATOM   741  N N   . LYS A 1 106 ? -4.38391  6.24057   28.46626  1.000 34.85667 ? 458 LYS A N   1 
ATOM   742  C CA  . LYS A 1 106 ? -4.76398  7.14809   29.54949  1.000 29.64158 ? 458 LYS A CA  1 
ATOM   743  C C   . LYS A 1 106 ? -3.55381  7.58139   30.36207  1.000 33.23756 ? 458 LYS A C   1 
ATOM   744  O O   . LYS A 1 106 ? -3.48819  8.72834   30.81526  1.000 42.67659 ? 458 LYS A O   1 
ATOM   745  C CB  . LYS A 1 106 ? -5.80228  6.49872   30.46213  1.000 30.89359 ? 458 LYS A CB  1 
ATOM   746  C CG  . LYS A 1 106 ? -7.08842  6.06951   29.75903  1.000 40.09415 ? 458 LYS A CG  1 
ATOM   747  C CD  . LYS A 1 106 ? -7.73659  7.22699   29.00010  1.000 50.61121 ? 458 LYS A CD  1 
ATOM   748  C CE  . LYS A 1 106 ? -8.21723  8.33403   29.94907  1.000 62.18123 ? 458 LYS A CE  1 
ATOM   749  N NZ  . LYS A 1 106 ? -8.93185  9.42579   29.21247  1.000 62.01423 ? 458 LYS A NZ  1 
ATOM   750  N N   . TYR A 1 107 ? -2.58845  6.69171   30.54660  1.000 34.40093 ? 459 TYR A N   1 
ATOM   751  C CA  . TYR A 1 107 ? -1.39038  7.04545   31.30010  1.000 37.14124 ? 459 TYR A CA  1 
ATOM   752  C C   . TYR A 1 107 ? -0.56634  8.10970   30.57845  1.000 43.09697 ? 459 TYR A C   1 
ATOM   753  O O   . TYR A 1 107 ? -0.12040  9.08077   31.19908  1.000 39.43608 ? 459 TYR A O   1 
ATOM   754  C CB  . TYR A 1 107 ? -0.55214  5.80341   31.55684  1.000 29.74634 ? 459 TYR A CB  1 
ATOM   755  C CG  . TYR A 1 107 ? 0.66630   6.06817   32.39846  1.000 33.01553 ? 459 TYR A CG  1 
ATOM   756  C CD1 . TYR A 1 107 ? 0.59977   5.99163   33.78289  1.000 34.18895 ? 459 TYR A CD1 1 
ATOM   757  C CD2 . TYR A 1 107 ? 1.87715   6.39118   31.81684  1.000 37.69933 ? 459 TYR A CD2 1 
ATOM   758  C CE1 . TYR A 1 107 ? 1.70918   6.23367   34.56155  1.000 39.82866 ? 459 TYR A CE1 1 
ATOM   759  C CE2 . TYR A 1 107 ? 3.00213   6.63015   32.58957  1.000 35.15815 ? 459 TYR A CE2 1 
ATOM   760  C CZ  . TYR A 1 107 ? 2.90543   6.54946   33.96330  1.000 41.20926 ? 459 TYR A CZ  1 
ATOM   761  O OH  . TYR A 1 107 ? 4.01331   6.79002   34.74060  1.000 45.92026 ? 459 TYR A OH  1 
ATOM   762  N N   . LEU A 1 108 ? -0.34415  7.94738   29.26635  1.000 34.73664 ? 460 LEU A N   1 
ATOM   763  C CA  . LEU A 1 108 ? 0.43255   8.95482   28.54654  1.000 40.06258 ? 460 LEU A CA  1 
ATOM   764  C C   . LEU A 1 108 ? -0.31501  10.27954  28.46576  1.000 36.31605 ? 460 LEU A C   1 
ATOM   765  O O   . LEU A 1 108 ? 0.31497   11.34523  28.49220  1.000 40.51347 ? 460 LEU A O   1 
ATOM   766  C CB  . LEU A 1 108 ? 0.80121   8.46234   27.14645  1.000 29.94208 ? 460 LEU A CB  1 
ATOM   767  C CG  . LEU A 1 108 ? 1.74586   7.26660   27.06634  1.000 36.67319 ? 460 LEU A CG  1 
ATOM   768  C CD1 . LEU A 1 108 ? 1.92100   6.85774   25.61653  1.000 32.75877 ? 460 LEU A CD1 1 
ATOM   769  C CD2 . LEU A 1 108 ? 3.10269   7.57568   27.72176  1.000 42.68750 ? 460 LEU A CD2 1 
ATOM   770  N N   . GLN A 1 109 ? -1.64871  10.23118  28.39004  1.000 34.62853 ? 461 GLN A N   1 
ATOM   771  C CA  . GLN A 1 109 ? -2.44578  11.45370  28.38641  1.000 35.27049 ? 461 GLN A CA  1 
ATOM   772  C C   . GLN A 1 109 ? -2.17488  12.29557  29.62745  1.000 53.33366 ? 461 GLN A C   1 
ATOM   773  O O   . GLN A 1 109 ? -2.15403  13.53251  29.56050  1.000 45.06010 ? 461 GLN A O   1 
ATOM   774  C CB  . GLN A 1 109 ? -3.93073  11.11332  28.30635  1.000 35.86590 ? 461 GLN A CB  1 
ATOM   775  C CG  . GLN A 1 109 ? -4.41658  10.70093  26.93289  1.000 36.42574 ? 461 GLN A CG  1 
ATOM   776  C CD  . GLN A 1 109 ? -5.82469  10.14635  26.98080  1.000 43.73023 ? 461 GLN A CD  1 
ATOM   777  O OE1 . GLN A 1 109 ? -6.53428  10.32627  27.97264  1.000 47.81374 ? 461 GLN A OE1 1 
ATOM   778  N NE2 . GLN A 1 109 ? -6.23251  9.45057   25.91899  1.000 45.07319 ? 461 GLN A NE2 1 
ATOM   779  N N   . GLN A 1 110 ? -1.95195  11.64144  30.76701  1.000 44.10099 ? 462 GLN A N   1 
ATOM   780  C CA  . GLN A 1 110 ? -1.77974  12.31576  32.04271  1.000 45.89055 ? 462 GLN A CA  1 
ATOM   781  C C   . GLN A 1 110 ? -0.32032  12.40857  32.46472  1.000 42.02152 ? 462 GLN A C   1 
ATOM   782  O O   . GLN A 1 110 ? -0.03552  12.78204  33.60723  1.000 47.13096 ? 462 GLN A O   1 
ATOM   783  C CB  . GLN A 1 110 ? -2.61240  11.60060  33.11055  1.000 41.41060 ? 462 GLN A CB  1 
ATOM   784  C CG  . GLN A 1 110 ? -4.10835  11.81901  32.93130  1.000 45.74150 ? 462 GLN A CG  1 
ATOM   785  C CD  . GLN A 1 110 ? -4.91749  10.53532  33.01021  1.000 60.92179 ? 462 GLN A CD  1 
ATOM   786  O OE1 . GLN A 1 110 ? -4.65446  9.67130   33.84635  1.000 61.89494 ? 462 GLN A OE1 1 
ATOM   787  N NE2 . GLN A 1 110 ? -5.90645  10.40210  32.12699  1.000 62.69710 ? 462 GLN A NE2 1 
ATOM   788  N N   . ASN A 1 111 ? 0.60621   12.09756  31.56790  1.000 40.93809 ? 463 ASN A N   1 
ATOM   789  C CA  . ASN A 1 111 ? 2.02781   12.05811  31.87037  1.000 40.53930 ? 463 ASN A CA  1 
ATOM   790  C C   . ASN A 1 111 ? 2.80512   12.46825  30.61962  1.000 38.58769 ? 463 ASN A C   1 
ATOM   791  O O   . ASN A 1 111 ? 3.59364   11.70708  30.05946  1.000 39.12456 ? 463 ASN A O   1 
ATOM   792  C CB  . ASN A 1 111 ? 2.42972   10.66847  32.36248  1.000 46.29091 ? 463 ASN A CB  1 
ATOM   793  C CG  . ASN A 1 111 ? 1.95388   10.38962  33.77338  1.000 48.20036 ? 463 ASN A CG  1 
ATOM   794  O OD1 . ASN A 1 111 ? 2.64611   10.71158  34.73714  1.000 44.28180 ? 463 ASN A OD1 1 
ATOM   795  N ND2 . ASN A 1 111 ? 0.76872   9.79166   33.90346  1.000 35.85416 ? 463 ASN A ND2 1 
ATOM   796  N N   . ARG A 1 112 ? 2.57407   13.70368  30.16159  1.000 49.84076 ? 464 ARG A N   1 
ATOM   797  C CA  . ARG A 1 112 ? 3.22014   14.20414  28.95255  1.000 44.12504 ? 464 ARG A CA  1 
ATOM   798  C C   . ARG A 1 112 ? 4.73374   14.27279  29.08080  1.000 47.90219 ? 464 ARG A C   1 
ATOM   799  O O   . ARG A 1 112 ? 5.41101   14.47453  28.06661  1.000 49.39986 ? 464 ARG A O   1 
ATOM   800  C CB  . ARG A 1 112 ? 2.68138   15.59513  28.60065  1.000 52.47820 ? 464 ARG A CB  1 
ATOM   801  C CG  . ARG A 1 112 ? 1.17221   15.74384  28.71571  1.000 47.98020 ? 464 ARG A CG  1 
ATOM   802  C CD  . ARG A 1 112 ? 0.43806   14.91464  27.67557  1.000 52.98696 ? 464 ARG A CD  1 
ATOM   803  N NE  . ARG A 1 112 ? -0.34201  15.75257  26.77125  1.000 55.76905 ? 464 ARG A NE  1 
ATOM   804  C CZ  . ARG A 1 112 ? 0.05435   16.11876  25.55908  1.000 60.19031 ? 464 ARG A CZ  1 
ATOM   805  N NH1 . ARG A 1 112 ? 1.20631   15.70449  25.05250  1.000 65.94792 ? 464 ARG A NH1 1 
ATOM   806  N NH2 . ARG A 1 112 ? -0.72275  16.92280  24.83685  1.000 69.78584 ? 464 ARG A NH2 1 
ATOM   807  N N   . HIS A 1 113 ? 5.27453   14.11002  30.29230  1.000 44.26368 ? 465 HIS A N   1 
ATOM   808  C CA  . HIS A 1 113 ? 6.70679   14.19146  30.54621  1.000 44.83136 ? 465 HIS A CA  1 
ATOM   809  C C   . HIS A 1 113 ? 7.45662   12.91703  30.18121  1.000 53.83719 ? 465 HIS A C   1 
ATOM   810  O O   . HIS A 1 113 ? 8.69496   12.93904  30.16566  1.000 47.59796 ? 465 HIS A O   1 
ATOM   811  C CB  . HIS A 1 113 ? 6.95646   14.51051  32.02587  1.000 50.70162 ? 465 HIS A CB  1 
ATOM   812  C CG  . HIS A 1 113 ? 6.52537   13.41352  32.95165  1.000 53.08104 ? 465 HIS A CG  1 
ATOM   813  N ND1 . HIS A 1 113 ? 7.36116   12.38106  33.32143  1.000 54.54125 ? 465 HIS A ND1 1 
ATOM   814  C CD2 . HIS A 1 113 ? 5.33473   13.16360  33.54651  1.000 51.35962 ? 465 HIS A CD2 1 
ATOM   815  C CE1 . HIS A 1 113 ? 6.71006   11.55302  34.11942  1.000 55.60085 ? 465 HIS A CE1 1 
ATOM   816  N NE2 . HIS A 1 113 ? 5.47799   12.00446  34.27141  1.000 55.42065 ? 465 HIS A NE2 1 
ATOM   817  N N   . VAL A 1 114 ? 6.75250   11.81098  29.90690  1.000 43.75694 ? 466 VAL A N   1 
ATOM   818  C CA  . VAL A 1 114 ? 7.43475   10.57221  29.54519  1.000 42.99926 ? 466 VAL A CA  1 
ATOM   819  C C   . VAL A 1 114 ? 8.30816   10.81307  28.31932  1.000 49.31317 ? 466 VAL A C   1 
ATOM   820  O O   . VAL A 1 114 ? 7.88256   11.46337  27.35527  1.000 43.20518 ? 466 VAL A O   1 
ATOM   821  C CB  . VAL A 1 114 ? 6.40561   9.45650   29.31442  1.000 44.07307 ? 466 VAL A CB  1 
ATOM   822  C CG1 . VAL A 1 114 ? 7.04948   8.26256   28.63990  1.000 41.61980 ? 466 VAL A CG1 1 
ATOM   823  C CG2 . VAL A 1 114 ? 5.79412   9.04852   30.64598  1.000 48.79475 ? 466 VAL A CG2 1 
ATOM   824  N N   . LYS A 1 115 ? 9.55056   10.31757  28.36321  1.000 42.19982 ? 467 LYS A N   1 
ATOM   825  C CA  . LYS A 1 115 ? 10.51069  10.60105  27.30219  1.000 44.64865 ? 467 LYS A CA  1 
ATOM   826  C C   . LYS A 1 115 ? 10.31634  9.65136   26.11820  1.000 41.78229 ? 467 LYS A C   1 
ATOM   827  O O   . LYS A 1 115 ? 9.78224   8.55145   26.25184  1.000 45.33662 ? 467 LYS A O   1 
ATOM   828  C CB  . LYS A 1 115 ? 11.94972  10.48603  27.81372  1.000 46.42409 ? 467 LYS A CB  1 
ATOM   829  C CG  . LYS A 1 115 ? 12.14022  10.75078  29.31300  1.000 53.81276 ? 467 LYS A CG  1 
ATOM   830  C CD  . LYS A 1 115 ? 12.03882  9.45133   30.13702  1.000 65.51617 ? 467 LYS A CD  1 
ATOM   831  C CE  . LYS A 1 115 ? 12.23645  9.70730   31.62952  1.000 60.11427 ? 467 LYS A CE  1 
ATOM   832  N NZ  . LYS A 1 115 ? 12.18370  8.43915   32.41919  1.000 60.81015 ? 467 LYS A NZ  1 
ATOM   833  N N   . ASP A 1 116 ? 10.78293  10.08096  24.94179  1.000 42.12161 ? 468 ASP A N   1 
ATOM   834  C CA  . ASP A 1 116 ? 10.63461  9.23748   23.75989  1.000 49.27017 ? 468 ASP A CA  1 
ATOM   835  C C   . ASP A 1 116 ? 11.38581  7.91677   23.92275  1.000 40.51904 ? 468 ASP A C   1 
ATOM   836  O O   . ASP A 1 116 ? 10.88681  6.86411   23.51920  1.000 41.35541 ? 468 ASP A O   1 
ATOM   837  C CB  . ASP A 1 116 ? 11.08678  9.99311   22.50095  1.000 53.49193 ? 468 ASP A CB  1 
ATOM   838  C CG  . ASP A 1 116 ? 12.38934  10.76291  22.69756  1.000 66.93767 ? 468 ASP A CG  1 
ATOM   839  O OD1 . ASP A 1 116 ? 13.19349  10.39838  23.59025  1.000 58.53076 ? 468 ASP A OD1 1 
ATOM   840  O OD2 . ASP A 1 116 ? 12.60394  11.74473  21.94722  1.000 67.52024 ? 468 ASP A OD2 1 
ATOM   841  N N   . LYS A 1 117 ? 12.57511  7.94437   24.53493  1.000 32.52258 ? 469 LYS A N   1 
ATOM   842  C CA  . LYS A 1 117 ? 13.29751  6.70044   24.78965  1.000 40.09184 ? 469 LYS A CA  1 
ATOM   843  C C   . LYS A 1 117 ? 12.45214  5.73737   25.62605  1.000 37.26730 ? 469 LYS A C   1 
ATOM   844  O O   . LYS A 1 117 ? 12.44050  4.52152   25.37718  1.000 35.32181 ? 469 LYS A O   1 
ATOM   845  C CB  . LYS A 1 117 ? 14.62488  7.01410   25.48528  1.000 41.91620 ? 469 LYS A CB  1 
ATOM   846  C CG  . LYS A 1 117 ? 15.32994  5.81791   26.06569  1.000 39.39272 ? 469 LYS A CG  1 
ATOM   847  C CD  . LYS A 1 117 ? 16.19041  6.23358   27.25302  1.000 50.80875 ? 469 LYS A CD  1 
ATOM   848  C CE  . LYS A 1 117 ? 17.18265  5.14787   27.58518  1.000 55.21135 ? 469 LYS A CE  1 
ATOM   849  N NZ  . LYS A 1 117 ? 17.88744  4.73060   26.33986  1.000 66.99256 ? 469 LYS A NZ  1 
ATOM   850  N N   . ASN A 1 118 ? 11.73397  6.27824   26.61201  1.000 31.79778 ? 470 ASN A N   1 
ATOM   851  C CA  . ASN A 1 118 ? 10.79993  5.50487   27.42832  1.000 37.95374 ? 470 ASN A CA  1 
ATOM   852  C C   . ASN A 1 118 ? 9.70266   4.89007   26.55827  1.000 38.19757 ? 470 ASN A C   1 
ATOM   853  O O   . ASN A 1 118 ? 9.36838   3.70554   26.68891  1.000 37.88823 ? 470 ASN A O   1 
ATOM   854  C CB  . ASN A 1 118 ? 10.20425  6.43632   28.49399  1.000 37.35472 ? 470 ASN A CB  1 
ATOM   855  C CG  . ASN A 1 118 ? 9.56417   5.69636   29.66796  1.000 47.19433 ? 470 ASN A CG  1 
ATOM   856  O OD1 . ASN A 1 118 ? 9.32133   6.29162   30.72250  1.000 39.74063 ? 470 ASN A OD1 1 
ATOM   857  N ND2 . ASN A 1 118 ? 9.28602   4.40894   29.49334  1.000 37.93842 ? 470 ASN A ND2 1 
ATOM   858  N N   . ILE A 1 119 ? 9.13786   5.68599   25.65488  1.000 33.68588 ? 471 ILE A N   1 
ATOM   859  C CA  . ILE A 1 119 ? 8.07277   5.19095   24.78350  1.000 35.12776 ? 471 ILE A CA  1 
ATOM   860  C C   . ILE A 1 119 ? 8.59569   4.10111   23.85711  1.000 36.05739 ? 471 ILE A C   1 
ATOM   861  O O   . ILE A 1 119 ? 7.92061   3.08771   23.63179  1.000 33.68679 ? 471 ILE A O   1 
ATOM   862  C CB  . ILE A 1 119 ? 7.44181   6.36174   24.01018  1.000 32.37966 ? 471 ILE A CB  1 
ATOM   863  C CG1 . ILE A 1 119 ? 6.80614   7.33404   24.99916  1.000 31.84330 ? 471 ILE A CG1 1 
ATOM   864  C CG2 . ILE A 1 119 ? 6.38104   5.85995   23.04528  1.000 36.91156 ? 471 ILE A CG2 1 
ATOM   865  C CD1 . ILE A 1 119 ? 6.15451   8.53813   24.35570  1.000 40.70225 ? 471 ILE A CD1 1 
ATOM   866  N N   . ILE A 1 120 ? 9.81178   4.27289   23.31932  1.000 30.32236 ? 472 ILE A N   1 
ATOM   867  C CA  . ILE A 1 120 ? 10.39760  3.22672   22.48282  1.000 30.57562 ? 472 ILE A CA  1 
ATOM   868  C C   . ILE A 1 120 ? 10.46096  1.91413   23.25009  1.000 27.84789 ? 472 ILE A C   1 
ATOM   869  O O   . ILE A 1 120 ? 10.13621  0.84320   22.72236  1.000 36.61502 ? 472 ILE A O   1 
ATOM   870  C CB  . ILE A 1 120 ? 11.79478  3.64727   21.98758  1.000 29.55144 ? 472 ILE A CB  1 
ATOM   871  C CG1 . ILE A 1 120 ? 11.71795  4.95607   21.19922  1.000 30.84349 ? 472 ILE A CG1 1 
ATOM   872  C CG2 . ILE A 1 120 ? 12.39812  2.56166   21.12397  1.000 33.93861 ? 472 ILE A CG2 1 
ATOM   873  C CD1 . ILE A 1 120 ? 13.07343  5.49124   20.79296  1.000 35.68245 ? 472 ILE A CD1 1 
ATOM   874  N N   . GLU A 1 121 ? 10.88168  1.97890   24.51070  1.000 33.35032 ? 473 GLU A N   1 
ATOM   875  C CA  . GLU A 1 121 ? 10.97427  0.78162   25.33407  1.000 38.31825 ? 473 GLU A CA  1 
ATOM   876  C C   . GLU A 1 121 ? 9.61666   0.10676   25.46621  1.000 32.34912 ? 473 GLU A C   1 
ATOM   877  O O   . GLU A 1 121 ? 9.49794   -1.11701  25.30633  1.000 36.40851 ? 473 GLU A O   1 
ATOM   878  C CB  . GLU A 1 121 ? 11.53939  1.15110   26.70753  1.000 37.73319 ? 473 GLU A CB  1 
ATOM   879  C CG  . GLU A 1 121 ? 11.73916  -0.03189  27.63310  1.000 36.97381 ? 473 GLU A CG  1 
ATOM   880  C CD  . GLU A 1 121 ? 12.15940  0.39395   29.03064  1.000 49.91081 ? 473 GLU A CD  1 
ATOM   881  O OE1 . GLU A 1 121 ? 11.78846  1.52171   29.46524  1.000 43.38552 ? 473 GLU A OE1 1 
ATOM   882  O OE2 . GLU A 1 121 ? 12.86689  -0.40442  29.68717  1.000 47.75020 ? 473 GLU A OE2 1 
ATOM   883  N N   . LEU A 1 122 ? 8.57370   0.89227   25.74641  1.000 29.03827 ? 474 LEU A N   1 
ATOM   884  C CA  . LEU A 1 122 ? 7.24975   0.30788   25.96144  1.000 33.24922 ? 474 LEU A CA  1 
ATOM   885  C C   . LEU A 1 122 ? 6.68225   -0.30527  24.68412  1.000 31.92687 ? 474 LEU A C   1 
ATOM   886  O O   . LEU A 1 122 ? 6.16010   -1.42447  24.70916  1.000 28.46737 ? 474 LEU A O   1 
ATOM   887  C CB  . LEU A 1 122 ? 6.29439   1.35715   26.51850  1.000 26.13499 ? 474 LEU A CB  1 
ATOM   888  C CG  . LEU A 1 122 ? 6.65734   1.92905   27.88791  1.000 28.44412 ? 474 LEU A CG  1 
ATOM   889  C CD1 . LEU A 1 122 ? 5.72191   3.09237   28.21154  1.000 32.57773 ? 474 LEU A CD1 1 
ATOM   890  C CD2 . LEU A 1 122 ? 6.57594   0.85254   28.95879  1.000 29.32837 ? 474 LEU A CD2 1 
ATOM   891  N N   . VAL A 1 123 ? 6.77111   0.39921   23.54919  1.000 25.48449 ? 475 VAL A N   1 
ATOM   892  C CA  . VAL A 1 123 ? 6.24438   -0.21769  22.33290  1.000 26.77394 ? 475 VAL A CA  1 
ATOM   893  C C   . VAL A 1 123 ? 7.10930   -1.40100  21.90672  1.000 32.06179 ? 475 VAL A C   1 
ATOM   894  O O   . VAL A 1 123 ? 6.60819   -2.34378  21.28554  1.000 25.45808 ? 475 VAL A O   1 
ATOM   895  C CB  . VAL A 1 123 ? 6.08678   0.81473   21.19519  1.000 31.90065 ? 475 VAL A CB  1 
ATOM   896  C CG1 . VAL A 1 123 ? 5.09816   1.92861   21.60377  1.000 33.98988 ? 475 VAL A CG1 1 
ATOM   897  C CG2 . VAL A 1 123 ? 7.43279   1.38383   20.78569  1.000 25.38230 ? 475 VAL A CG2 1 
ATOM   898  N N   . HIS A 1 124 ? 8.40813   -1.39983  22.24837  1.000 28.89821 ? 476 HIS A N   1 
ATOM   899  C CA  . HIS A 1 124 ? 9.23018   -2.57129  21.94670  1.000 27.20487 ? 476 HIS A CA  1 
ATOM   900  C C   . HIS A 1 124 ? 8.74707   -3.78457  22.72313  1.000 27.04610 ? 476 HIS A C   1 
ATOM   901  O O   . HIS A 1 124 ? 8.72567   -4.89794  22.18787  1.000 32.42501 ? 476 HIS A O   1 
ATOM   902  C CB  . HIS A 1 124 ? 10.72228  -2.31016  22.24424  1.000 31.49321 ? 476 HIS A CB  1 
ATOM   903  C CG  . HIS A 1 124 ? 11.59028  -3.52981  22.09437  1.000 32.90226 ? 476 HIS A CG  1 
ATOM   904  N ND1 . HIS A 1 124 ? 12.35687  -4.03943  23.12307  1.000 34.67651 ? 476 HIS A ND1 1 
ATOM   905  C CD2 . HIS A 1 124 ? 11.78294  -4.35858  21.04124  1.000 32.03390 ? 476 HIS A CD2 1 
ATOM   906  C CE1 . HIS A 1 124 ? 12.98512  -5.12695  22.70712  1.000 32.22562 ? 476 HIS A CE1 1 
ATOM   907  N NE2 . HIS A 1 124 ? 12.65816  -5.33912  21.44542  1.000 31.99477 ? 476 HIS A NE2 1 
ATOM   908  N N   . GLN A 1 125 ? 8.33409   -3.58863  23.98127  1.000 33.07581 ? 477 GLN A N   1 
ATOM   909  C CA  . GLN A 1 125 ? 7.81090   -4.70753  24.76248  1.000 32.63452 ? 477 GLN A CA  1 
ATOM   910  C C   . GLN A 1 125 ? 6.49170   -5.21002  24.18313  1.000 28.09461 ? 477 GLN A C   1 
ATOM   911  O O   . GLN A 1 125 ? 6.23402   -6.42202  24.16751  1.000 25.76341 ? 477 GLN A O   1 
ATOM   912  C CB  . GLN A 1 125 ? 7.64198   -4.30931  26.23499  1.000 33.52324 ? 477 GLN A CB  1 
ATOM   913  C CG  . GLN A 1 125 ? 8.94956   -4.18138  26.99944  1.000 39.14335 ? 477 GLN A CG  1 
ATOM   914  C CD  . GLN A 1 125 ? 8.83638   -3.29630  28.23409  1.000 39.59150 ? 477 GLN A CD  1 
ATOM   915  O OE1 . GLN A 1 125 ? 7.82401   -2.62104  28.44671  1.000 37.15620 ? 477 GLN A OE1 1 
ATOM   916  N NE2 . GLN A 1 125 ? 9.88707   -3.29397  29.05475  1.000 37.72435 ? 477 GLN A NE2 1 
ATOM   917  N N   . VAL A 1 126 ? 5.65446   -4.30215  23.68626  1.000 27.15822 ? 478 VAL A N   1 
ATOM   918  C CA  . VAL A 1 126 ? 4.45558   -4.73547  22.96382  1.000 27.99207 ? 478 VAL A CA  1 
ATOM   919  C C   . VAL A 1 126 ? 4.85164   -5.61099  21.77847  1.000 24.49612 ? 478 VAL A C   1 
ATOM   920  O O   . VAL A 1 126 ? 4.32081   -6.71267  21.60320  1.000 25.18181 ? 478 VAL A O   1 
ATOM   921  C CB  . VAL A 1 126 ? 3.61380   -3.52509  22.52100  1.000 27.58687 ? 478 VAL A CB  1 
ATOM   922  C CG1 . VAL A 1 126 ? 2.34771   -4.00652  21.78105  1.000 25.94866 ? 478 VAL A CG1 1 
ATOM   923  C CG2 . VAL A 1 126 ? 3.22515   -2.68164  23.72221  1.000 32.33021 ? 478 VAL A CG2 1 
ATOM   924  N N   . SER A 1 127 ? 5.86539   -5.17478  21.00079  1.000 29.75355 ? 479 SER A N   1 
ATOM   925  C CA  . SER A 1 127 ? 6.27616   -5.95028  19.82913  1.000 29.50898 ? 479 SER A CA  1 
ATOM   926  C C   . SER A 1 127 ? 6.78622   -7.33045  20.21486  1.000 25.66582 ? 479 SER A C   1 
ATOM   927  O O   . SER A 1 127 ? 6.62726   -8.27807  19.44234  1.000 29.85689 ? 479 SER A O   1 
ATOM   928  C CB  . SER A 1 127 ? 7.33128   -5.20305  19.01271  1.000 29.60664 ? 479 SER A CB  1 
ATOM   929  O OG  . SER A 1 127 ? 8.64573   -5.39171  19.52549  1.000 31.41142 ? 479 SER A OG  1 
ATOM   930  N N   . MET A 1 128 ? 7.41216   -7.47106  21.39118  1.000 31.34140 ? 480 MET A N   1 
ATOM   931  C CA  . MET A 1 128 ? 7.84784   -8.79783  21.82350  1.000 30.80323 ? 480 MET A CA  1 
ATOM   932  C C   . MET A 1 128 ? 6.65568   -9.65529  22.23127  1.000 24.04401 ? 480 MET A C   1 
ATOM   933  O O   . MET A 1 128 ? 6.60111   -10.85237 21.91380  1.000 27.83077 ? 480 MET A O   1 
ATOM   934  C CB  . MET A 1 128 ? 8.84669   -8.69406  22.98769  1.000 30.93641 ? 480 MET A CB  1 
ATOM   935  C CG  . MET A 1 128 ? 10.25360  -8.17541  22.59430  1.000 26.41804 ? 480 MET A CG  1 
ATOM   936  S SD  . MET A 1 128 ? 11.40683  -8.17525  23.99050  1.000 38.44539 ? 480 MET A SD  1 
ATOM   937  C CE  . MET A 1 128 ? 10.91946  -6.68675  24.84288  1.000 28.57248 ? 480 MET A CE  1 
ATOM   938  N N   . GLY A 1 129 ? 5.71080   -9.07727  22.96402  1.000 28.36133 ? 481 GLY A N   1 
ATOM   939  C CA  . GLY A 1 129 ? 4.47349   -9.79510  23.22399  1.000 26.94087 ? 481 GLY A CA  1 
ATOM   940  C C   . GLY A 1 129 ? 3.80729   -10.25063 21.94551  1.000 29.35054 ? 481 GLY A C   1 
ATOM   941  O O   . GLY A 1 129 ? 3.35780   -11.39358 21.83910  1.000 33.49248 ? 481 GLY A O   1 
ATOM   942  N N   . MET A 1 130 ? 3.77173   -9.37075  20.93334  1.000 33.80315 ? 482 MET A N   1 
ATOM   943  C CA  . MET A 1 130 ? 3.11365   -9.70389  19.66896  1.000 27.69187 ? 482 MET A CA  1 
ATOM   944  C C   . MET A 1 130 ? 3.94252   -10.66210 18.81886  1.000 28.17686 ? 482 MET A C   1 
ATOM   945  O O   . MET A 1 130 ? 3.38024   -11.43912 18.04056  1.000 25.22661 ? 482 MET A O   1 
ATOM   946  C CB  . MET A 1 130 ? 2.81492   -8.42753  18.88552  1.000 29.11669 ? 482 MET A CB  1 
ATOM   947  C CG  . MET A 1 130 ? 1.78733   -7.54936  19.54676  1.000 31.84039 ? 482 MET A CG  1 
ATOM   948  S SD  . MET A 1 130 ? 0.20413   -8.41453  19.65781  1.000 29.05212 ? 482 MET A SD  1 
ATOM   949  C CE  . MET A 1 130 ? -0.04245  -8.88433  17.94919  1.000 29.02495 ? 482 MET A CE  1 
ATOM   950  N N   . LYS A 1 131 ? 5.27157   -10.62055 18.93511  1.000 28.62723 ? 483 LYS A N   1 
ATOM   951  C CA  . LYS A 1 131 ? 6.08385   -11.64750 18.28751  1.000 26.77946 ? 483 LYS A CA  1 
ATOM   952  C C   . LYS A 1 131 ? 5.74047   -13.02031 18.84782  1.000 26.29001 ? 483 LYS A C   1 
ATOM   953  O O   . LYS A 1 131 ? 5.55781   -13.98513 18.09814  1.000 30.78432 ? 483 LYS A O   1 
ATOM   954  C CB  . LYS A 1 131 ? 7.57200   -11.32822 18.48495  1.000 30.71377 ? 483 LYS A CB  1 
ATOM   955  C CG  . LYS A 1 131 ? 8.53223   -12.15242 17.64438  1.000 37.03481 ? 483 LYS A CG  1 
ATOM   956  C CD  . LYS A 1 131 ? 9.96186   -11.76332 18.00913  1.000 38.65755 ? 483 LYS A CD  1 
ATOM   957  C CE  . LYS A 1 131 ? 10.95576  -12.84128 17.61003  1.000 48.77551 ? 483 LYS A CE  1 
ATOM   958  N NZ  . LYS A 1 131 ? 12.33307  -12.28670 17.69264  1.000 43.76492 ? 483 LYS A NZ  1 
ATOM   959  N N   . TYR A 1 132 ? 5.63116   -13.11300 20.17641  1.000 28.76064 ? 484 TYR A N   1 
ATOM   960  C CA  . TYR A 1 132 ? 5.20454   -14.34808 20.81962  1.000 33.80393 ? 484 TYR A CA  1 
ATOM   961  C C   . TYR A 1 132 ? 3.84209   -14.79798 20.30000  1.000 32.74131 ? 484 TYR A C   1 
ATOM   962  O O   . TYR A 1 132 ? 3.66712   -15.95672 19.91193  1.000 32.50068 ? 484 TYR A O   1 
ATOM   963  C CB  . TYR A 1 132 ? 5.17356   -14.15006 22.33663  1.000 34.07706 ? 484 TYR A CB  1 
ATOM   964  C CG  . TYR A 1 132 ? 4.48405   -15.27464 23.08006  1.000 37.26172 ? 484 TYR A CG  1 
ATOM   965  C CD1 . TYR A 1 132 ? 5.14851   -16.47328 23.34174  1.000 46.48873 ? 484 TYR A CD1 1 
ATOM   966  C CD2 . TYR A 1 132 ? 3.17244   -15.13909 23.51474  1.000 33.59056 ? 484 TYR A CD2 1 
ATOM   967  C CE1 . TYR A 1 132 ? 4.52629   -17.50240 24.01887  1.000 32.86181 ? 484 TYR A CE1 1 
ATOM   968  C CE2 . TYR A 1 132 ? 2.54024   -16.15623 24.18885  1.000 37.17353 ? 484 TYR A CE2 1 
ATOM   969  C CZ  . TYR A 1 132 ? 3.21620   -17.33471 24.43673  1.000 39.13090 ? 484 TYR A CZ  1 
ATOM   970  O OH  . TYR A 1 132 ? 2.58010   -18.33736 25.11023  1.000 42.37040 ? 484 TYR A OH  1 
ATOM   971  N N   . LEU A 1 133 ? 2.86514   -13.88324 20.26973  1.000 31.03791 ? 485 LEU A N   1 
ATOM   972  C CA  . LEU A 1 133 ? 1.53943   -14.22276 19.74830  1.000 25.95713 ? 485 LEU A CA  1 
ATOM   973  C C   . LEU A 1 133 ? 1.61605   -14.66021 18.29345  1.000 27.50476 ? 485 LEU A C   1 
ATOM   974  O O   . LEU A 1 133 ? 0.93715   -15.60941 17.88441  1.000 34.92929 ? 485 LEU A O   1 
ATOM   975  C CB  . LEU A 1 133 ? 0.58346   -13.02729 19.88380  1.000 28.07098 ? 485 LEU A CB  1 
ATOM   976  C CG  . LEU A 1 133 ? -0.09598  -12.81052 21.23130  1.000 33.53009 ? 485 LEU A CG  1 
ATOM   977  C CD1 . LEU A 1 133 ? -0.89227  -11.49947 21.22965  1.000 38.98711 ? 485 LEU A CD1 1 
ATOM   978  C CD2 . LEU A 1 133 ? -1.01473  -13.97282 21.53554  1.000 36.19922 ? 485 LEU A CD2 1 
ATOM   979  N N   . GLU A 1 134 ? 2.45978   -13.99992 17.50292  1.000 24.29170 ? 486 GLU A N   1 
ATOM   980  C CA  . GLU A 1 134 ? 2.59372   -14.36735 16.09666  1.000 31.87333 ? 486 GLU A CA  1 
ATOM   981  C C   . GLU A 1 134 ? 3.18809   -15.76830 15.94568  1.000 28.15989 ? 486 GLU A C   1 
ATOM   982  O O   . GLU A 1 134 ? 2.71412   -16.57222 15.13711  1.000 36.01874 ? 486 GLU A O   1 
ATOM   983  C CB  . GLU A 1 134 ? 3.45939   -13.32600 15.39015  1.000 29.26417 ? 486 GLU A CB  1 
ATOM   984  C CG  . GLU A 1 134 ? 3.78796   -13.59167 13.94291  1.000 30.18871 ? 486 GLU A CG  1 
ATOM   985  C CD  . GLU A 1 134 ? 4.73498   -12.52894 13.41143  1.000 44.77340 ? 486 GLU A CD  1 
ATOM   986  O OE1 . GLU A 1 134 ? 5.93204   -12.53672 13.79242  1.000 46.63192 ? 486 GLU A OE1 1 
ATOM   987  O OE2 . GLU A 1 134 ? 4.27825   -11.64593 12.65723  1.000 40.61663 ? 486 GLU A OE2 1 
ATOM   988  N N   . GLU A 1 135 ? 4.24117   -16.07449 16.71072  1.000 39.66465 ? 487 GLU A N   1 
ATOM   989  C CA  . GLU A 1 135 ? 4.83952   -17.41140 16.64099  1.000 35.92777 ? 487 GLU A CA  1 
ATOM   990  C C   . GLU A 1 135 ? 3.89948   -18.47278 17.17755  1.000 37.28093 ? 487 GLU A C   1 
ATOM   991  O O   . GLU A 1 135 ? 4.00739   -19.64937 16.80251  1.000 36.72408 ? 487 GLU A O   1 
ATOM   992  C CB  . GLU A 1 135 ? 6.13937   -17.45253 17.42765  1.000 35.20549 ? 487 GLU A CB  1 
ATOM   993  C CG  . GLU A 1 135 ? 7.12510   -16.39906 17.02890  1.000 45.12715 ? 487 GLU A CG  1 
ATOM   994  C CD  . GLU A 1 135 ? 8.27855   -16.34187 17.99541  1.000 55.14734 ? 487 GLU A CD  1 
ATOM   995  O OE1 . GLU A 1 135 ? 8.10753   -16.83790 19.13351  1.000 58.94961 ? 487 GLU A OE1 1 
ATOM   996  O OE2 . GLU A 1 135 ? 9.34998   -15.82440 17.61304  1.000 54.12642 ? 487 GLU A OE2 1 
ATOM   997  N N   . SER A 1 136 ? 3.00868   -18.08347 18.08647  1.000 31.36557 ? 488 SER A N   1 
ATOM   998  C CA  . SER A 1 136 ? 1.96403   -18.94804 18.60953  1.000 32.15699 ? 488 SER A CA  1 
ATOM   999  C C   . SER A 1 136 ? 0.78423   -19.08060 17.66155  1.000 30.99105 ? 488 SER A C   1 
ATOM   1000 O O   . SER A 1 136 ? -0.11978  -19.87077 17.93741  1.000 34.24391 ? 488 SER A O   1 
ATOM   1001 C CB  . SER A 1 136 ? 1.47265   -18.41272 19.95308  1.000 34.06929 ? 488 SER A CB  1 
ATOM   1002 O OG  . SER A 1 136 ? 2.53850   -18.27674 20.87473  1.000 35.67940 ? 488 SER A OG  1 
ATOM   1003 N N   . ASN A 1 137 ? 0.78449   -18.32917 16.55942  1.000 37.11305 ? 489 ASN A N   1 
ATOM   1004 C CA  . ASN A 1 137 ? -0.27742  -18.35139 15.55370  1.000 30.25673 ? 489 ASN A CA  1 
ATOM   1005 C C   . ASN A 1 137 ? -1.62702  -17.97648 16.15665  1.000 32.39999 ? 489 ASN A C   1 
ATOM   1006 O O   . ASN A 1 137 ? -2.65927  -18.57474 15.84422  1.000 34.60882 ? 489 ASN A O   1 
ATOM   1007 C CB  . ASN A 1 137 ? -0.34274  -19.69712 14.82616  1.000 37.41776 ? 489 ASN A CB  1 
ATOM   1008 C CG  . ASN A 1 137 ? 0.86637   -19.91657 13.92419  1.000 52.23630 ? 489 ASN A CG  1 
ATOM   1009 O OD1 . ASN A 1 137 ? 1.36381   -18.97732 13.28690  1.000 48.29564 ? 489 ASN A OD1 1 
ATOM   1010 N ND2 . ASN A 1 137 ? 1.36191   -21.14984 13.88640  1.000 53.56621 ? 489 ASN A ND2 1 
ATOM   1011 N N   . PHE A 1 138 ? -1.61163  -16.96053 17.02149  1.000 32.21714 ? 490 PHE A N   1 
ATOM   1012 C CA  . PHE A 1 138 ? -2.80916  -16.25369 17.45788  1.000 36.26635 ? 490 PHE A CA  1 
ATOM   1013 C C   . PHE A 1 138 ? -2.82277  -14.87404 16.81256  1.000 29.17464 ? 490 PHE A C   1 
ATOM   1014 O O   . PHE A 1 138 ? -1.77698  -14.23295 16.69654  1.000 29.95870 ? 490 PHE A O   1 
ATOM   1015 C CB  . PHE A 1 138 ? -2.83583  -16.08775 18.97836  1.000 31.76651 ? 490 PHE A CB  1 
ATOM   1016 C CG  . PHE A 1 138 ? -3.41366  -17.25556 19.71962  1.000 36.34391 ? 490 PHE A CG  1 
ATOM   1017 C CD1 . PHE A 1 138 ? -2.61428  -18.32232 20.09703  1.000 38.03286 ? 490 PHE A CD1 1 
ATOM   1018 C CD2 . PHE A 1 138 ? -4.75284  -17.26169 20.08512  1.000 39.06664 ? 490 PHE A CD2 1 
ATOM   1019 C CE1 . PHE A 1 138 ? -3.14656  -19.38656 20.80347  1.000 39.89750 ? 490 PHE A CE1 1 
ATOM   1020 C CE2 . PHE A 1 138 ? -5.28832  -18.33015 20.79134  1.000 41.15709 ? 490 PHE A CE2 1 
ATOM   1021 C CZ  . PHE A 1 138 ? -4.48339  -19.38355 21.15105  1.000 35.30486 ? 490 PHE A CZ  1 
ATOM   1022 N N   . VAL A 1 139 ? -3.99612  -14.41283 16.39374  1.000 24.48780 ? 491 VAL A N   1 
ATOM   1023 C CA  . VAL A 1 139 ? -4.16361  -13.02422 15.97453  1.000 26.07162 ? 491 VAL A CA  1 
ATOM   1024 C C   . VAL A 1 139 ? -4.90883  -12.27887 17.07274  1.000 32.22001 ? 491 VAL A C   1 
ATOM   1025 O O   . VAL A 1 139 ? -5.88114  -12.79717 17.62751  1.000 28.74152 ? 491 VAL A O   1 
ATOM   1026 C CB  . VAL A 1 139 ? -4.89044  -12.92525 14.61765  1.000 24.63991 ? 491 VAL A CB  1 
ATOM   1027 C CG1 . VAL A 1 139 ? -6.24360  -13.64588 14.63767  1.000 29.16223 ? 491 VAL A CG1 1 
ATOM   1028 C CG2 . VAL A 1 139 ? -5.04376  -11.45989 14.18876  1.000 35.79676 ? 491 VAL A CG2 1 
ATOM   1029 N N   . HIS A 1 140 ? -4.45284  -11.05930 17.38826  1.000 30.99474 ? 492 HIS A N   1 
ATOM   1030 C CA  . HIS A 1 140 ? -5.05245  -10.31159 18.49267  1.000 31.26125 ? 492 HIS A CA  1 
ATOM   1031 C C   . HIS A 1 140 ? -6.37223  -9.68239  18.08144  1.000 25.77402 ? 492 HIS A C   1 
ATOM   1032 O O   . HIS A 1 140 ? -7.38964  -9.85060  18.76678  1.000 29.24525 ? 492 HIS A O   1 
ATOM   1033 C CB  . HIS A 1 140 ? -4.11158  -9.21764  18.99340  1.000 24.28681 ? 492 HIS A CB  1 
ATOM   1034 C CG  . HIS A 1 140 ? -4.58629  -8.56895  20.25986  1.000 26.46952 ? 492 HIS A CG  1 
ATOM   1035 N ND1 . HIS A 1 140 ? -5.52042  -7.55329  20.27577  1.000 34.90112 ? 492 HIS A ND1 1 
ATOM   1036 C CD2 . HIS A 1 140 ? -4.28756  -8.82452  21.55635  1.000 25.69708 ? 492 HIS A CD2 1 
ATOM   1037 C CE1 . HIS A 1 140 ? -5.76199  -7.20116  21.52813  1.000 35.86869 ? 492 HIS A CE1 1 
ATOM   1038 N NE2 . HIS A 1 140 ? -5.02115  -7.95424  22.32407  1.000 28.28217 ? 492 HIS A NE2 1 
ATOM   1039 N N   . ARG A 1 141 ? -6.33867  -8.91216  16.99143  1.000 27.08897 ? 493 ARG A N   1 
ATOM   1040 C CA  . ARG A 1 141 ? -7.45437  -8.28482  16.28465  1.000 27.32538 ? 493 ARG A CA  1 
ATOM   1041 C C   . ARG A 1 141 ? -8.00942  -7.06180  16.99817  1.000 32.87086 ? 493 ARG A C   1 
ATOM   1042 O O   . ARG A 1 141 ? -9.00516  -6.49763  16.54895  1.000 33.31924 ? 493 ARG A O   1 
ATOM   1043 C CB  . ARG A 1 141 ? -8.58938  -9.27074  16.00019  1.000 28.92711 ? 493 ARG A CB  1 
ATOM   1044 C CG  . ARG A 1 141 ? -8.14949  -10.38569 15.08242  1.000 31.08595 ? 493 ARG A CG  1 
ATOM   1045 C CD  . ARG A 1 141 ? -9.24351  -11.38275 14.81147  1.000 36.35451 ? 493 ARG A CD  1 
ATOM   1046 N NE  . ARG A 1 141 ? -10.33576 -10.79555 14.05309  1.000 44.25209 ? 493 ARG A NE  1 
ATOM   1047 C CZ  . ARG A 1 141 ? -11.60063 -10.80556 14.44458  1.000 38.44353 ? 493 ARG A CZ  1 
ATOM   1048 N NH1 . ARG A 1 141 ? -11.96874 -11.38739 15.57188  1.000 38.73501 ? 493 ARG A NH1 1 
ATOM   1049 N NH2 . ARG A 1 141 ? -12.52008 -10.22695 13.67891  1.000 46.17903 ? 493 ARG A NH2 1 
ATOM   1050 N N   . ASP A 1 142 ? -7.37591  -6.61591  18.07101  1.000 28.36245 ? 494 ASP A N   1 
ATOM   1051 C CA  . ASP A 1 142 ? -7.79620  -5.38977  18.74597  1.000 30.50991 ? 494 ASP A CA  1 
ATOM   1052 C C   . ASP A 1 142 ? -6.57172  -4.73304  19.37114  1.000 28.50193 ? 494 ASP A C   1 
ATOM   1053 O O   . ASP A 1 142 ? -6.56086  -4.38077  20.55014  1.000 32.72121 ? 494 ASP A O   1 
ATOM   1054 C CB  . ASP A 1 142 ? -8.86910  -5.71045  19.78909  1.000 27.56518 ? 494 ASP A CB  1 
ATOM   1055 C CG  . ASP A 1 142 ? -9.65050  -4.48869  20.23478  1.000 35.68739 ? 494 ASP A CG  1 
ATOM   1056 O OD1 . ASP A 1 142 ? -9.51899  -3.40402  19.61848  1.000 40.53440 ? 494 ASP A OD1 1 
ATOM   1057 O OD2 . ASP A 1 142 ? -10.40936 -4.62360  21.21785  1.000 31.71090 ? 494 ASP A OD2 1 
ATOM   1058 N N   . LEU A 1 143 ? -5.48379  -4.62224  18.60389  1.000 27.56429 ? 495 LEU A N   1 
ATOM   1059 C CA  . LEU A 1 143 ? -4.22236  -4.11771  19.14362  1.000 23.14009 ? 495 LEU A CA  1 
ATOM   1060 C C   . LEU A 1 143 ? -4.22786  -2.58956  19.08848  1.000 33.11987 ? 495 LEU A C   1 
ATOM   1061 O O   . LEU A 1 143 ? -3.88409  -1.98882  18.06933  1.000 35.42484 ? 495 LEU A O   1 
ATOM   1062 C CB  . LEU A 1 143 ? -3.04215  -4.69295  18.37314  1.000 28.05793 ? 495 LEU A CB  1 
ATOM   1063 C CG  . LEU A 1 143 ? -1.65161  -4.26939  18.86706  1.000 24.46079 ? 495 LEU A CG  1 
ATOM   1064 C CD1 . LEU A 1 143 ? -1.48592  -4.60655  20.34658  1.000 29.63100 ? 495 LEU A CD1 1 
ATOM   1065 C CD2 . LEU A 1 143 ? -0.59652  -4.95944  18.03635  1.000 22.91990 ? 495 LEU A CD2 1 
ATOM   1066 N N   . ALA A 1 144 ? -4.59260  -1.95634  20.19732  1.000 27.02603 ? 496 ALA A N   1 
ATOM   1067 C CA  . ALA A 1 144 ? -4.65012  -0.50329  20.28499  1.000 28.63724 ? 496 ALA A CA  1 
ATOM   1068 C C   . ALA A 1 144 ? -4.01877  -0.09295  21.60467  1.000 32.62983 ? 496 ALA A C   1 
ATOM   1069 O O   . ALA A 1 144 ? -3.86397  -0.91007  22.51358  1.000 28.30393 ? 496 ALA A O   1 
ATOM   1070 C CB  . ALA A 1 144 ? -6.10130  0.01810   20.17772  1.000 27.84469 ? 496 ALA A CB  1 
ATOM   1071 N N   . ALA A 1 145 ? -3.64473  1.18574   21.70791  1.000 26.50620 ? 497 ALA A N   1 
ATOM   1072 C CA  . ALA A 1 145 ? -2.97656  1.64543   22.92184  1.000 29.44423 ? 497 ALA A CA  1 
ATOM   1073 C C   . ALA A 1 145 ? -3.83036  1.41049   24.16802  1.000 26.89346 ? 497 ALA A C   1 
ATOM   1074 O O   . ALA A 1 145 ? -3.28813  1.14197   25.24192  1.000 28.79316 ? 497 ALA A O   1 
ATOM   1075 C CB  . ALA A 1 145 ? -2.59468  3.11994   22.77324  1.000 29.02767 ? 497 ALA A CB  1 
ATOM   1076 N N   . ARG A 1 146 ? -5.16075  1.46264   24.04352  1.000 27.99761 ? 498 ARG A N   1 
ATOM   1077 C CA  . ARG A 1 146 ? -6.02985  1.23747   25.19631  1.000 30.24918 ? 498 ARG A CA  1 
ATOM   1078 C C   . ARG A 1 146 ? -5.94422  -0.19160  25.73127  1.000 30.22423 ? 498 ARG A C   1 
ATOM   1079 O O   . ARG A 1 146 ? -6.34679  -0.43683  26.87647  1.000 28.69799 ? 498 ARG A O   1 
ATOM   1080 C CB  . ARG A 1 146 ? -7.48904  1.56107   24.83810  1.000 28.42528 ? 498 ARG A CB  1 
ATOM   1081 C CG  . ARG A 1 146 ? -8.11931  0.54405   23.91449  1.000 33.35510 ? 498 ARG A CG  1 
ATOM   1082 C CD  . ARG A 1 146 ? -9.58137  0.84342   23.52693  1.000 37.49257 ? 498 ARG A CD  1 
ATOM   1083 N NE  . ARG A 1 146 ? -9.97876  -0.04420  22.43260  1.000 50.34479 ? 498 ARG A NE  1 
ATOM   1084 C CZ  . ARG A 1 146 ? -9.80931  0.22715   21.14196  1.000 49.58326 ? 498 ARG A CZ  1 
ATOM   1085 N NH1 . ARG A 1 146 ? -9.36743  1.40656   20.73312  1.000 43.82049 ? 498 ARG A NH1 1 
ATOM   1086 N NH2 . ARG A 1 146 ? -10.08871 -0.70746  20.23732  1.000 47.07279 ? 498 ARG A NH2 1 
ATOM   1087 N N   . ASN A 1 147 ? -5.43096  -1.13225  24.93807  1.000 24.14078 ? 499 ASN A N   1 
ATOM   1088 C CA  . ASN A 1 147 ? -5.34382  -2.53657  25.32438  1.000 27.59834 ? 499 ASN A CA  1 
ATOM   1089 C C   . ASN A 1 147 ? -3.92509  -2.93786  25.74022  1.000 30.93756 ? 499 ASN A C   1 
ATOM   1090 O O   . ASN A 1 147 ? -3.61204  -4.13237  25.81608  1.000 29.37902 ? 499 ASN A O   1 
ATOM   1091 C CB  . ASN A 1 147 ? -5.85206  -3.40891  24.17004  1.000 25.28104 ? 499 ASN A CB  1 
ATOM   1092 C CG  . ASN A 1 147 ? -7.36100  -3.28262  23.96765  1.000 35.06157 ? 499 ASN A CG  1 
ATOM   1093 O OD1 . ASN A 1 147 ? -8.08435  -2.98226  24.91294  1.000 32.34534 ? 499 ASN A OD1 1 
ATOM   1094 N ND2 . ASN A 1 147 ? -7.84088  -3.52181  22.74150  1.000 30.45547 ? 499 ASN A ND2 1 
ATOM   1095 N N   . VAL A 1 148 ? -3.06105  -1.96096  25.99007  1.000 26.94840 ? 500 VAL A N   1 
ATOM   1096 C CA  . VAL A 1 148 ? -1.74026  -2.17014  26.57356  1.000 26.09329 ? 500 VAL A CA  1 
ATOM   1097 C C   . VAL A 1 148 ? -1.78829  -1.68703  28.01850  1.000 30.11341 ? 500 VAL A C   1 
ATOM   1098 O O   . VAL A 1 148 ? -2.16979  -0.54050  28.28138  1.000 27.85835 ? 500 VAL A O   1 
ATOM   1099 C CB  . VAL A 1 148 ? -0.65976  -1.41205  25.78526  1.000 28.89479 ? 500 VAL A CB  1 
ATOM   1100 C CG1 . VAL A 1 148 ? 0.68841   -1.55693  26.47218  1.000 28.30535 ? 500 VAL A CG1 1 
ATOM   1101 C CG2 . VAL A 1 148 ? -0.58979  -1.93689  24.36245  1.000 31.95767 ? 500 VAL A CG2 1 
ATOM   1102 N N   . LEU A 1 149 ? -1.39892  -2.54897  28.95055  1.000 29.55563 ? 501 LEU A N   1 
ATOM   1103 C CA  . LEU A 1 149 ? -1.45102  -2.22956  30.36862  1.000 33.08077 ? 501 LEU A CA  1 
ATOM   1104 C C   . LEU A 1 149 ? -0.03185  -2.03262  30.87731  1.000 33.06242 ? 501 LEU A C   1 
ATOM   1105 O O   . LEU A 1 149 ? 0.88753   -2.74376  30.45924  1.000 35.36564 ? 501 LEU A O   1 
ATOM   1106 C CB  . LEU A 1 149 ? -2.15961  -3.33221  31.15975  1.000 25.72717 ? 501 LEU A CB  1 
ATOM   1107 C CG  . LEU A 1 149 ? -3.69677  -3.28761  31.17878  1.000 34.56868 ? 501 LEU A CG  1 
ATOM   1108 C CD1 . LEU A 1 149 ? -4.16406  -2.00943  31.84757  1.000 32.43085 ? 501 LEU A CD1 1 
ATOM   1109 C CD2 . LEU A 1 149 ? -4.28615  -3.39250  29.78477  1.000 34.58135 ? 501 LEU A CD2 1 
ATOM   1110 N N   . LEU A 1 150 ? 0.14705   -1.04662  31.75503  1.000 30.97700 ? 502 LEU A N   1 
ATOM   1111 C CA  . LEU A 1 150 ? 1.45584   -0.72649  32.30945  1.000 31.94089 ? 502 LEU A CA  1 
ATOM   1112 C C   . LEU A 1 150 ? 1.58559   -1.33631  33.69965  1.000 30.50553 ? 502 LEU A C   1 
ATOM   1113 O O   . LEU A 1 150 ? 0.79801   -1.01585  34.59645  1.000 31.63111 ? 502 LEU A O   1 
ATOM   1114 C CB  . LEU A 1 150 ? 1.66492   0.78762   32.35405  1.000 27.34354 ? 502 LEU A CB  1 
ATOM   1115 C CG  . LEU A 1 150 ? 1.66140   1.45015   30.97238  1.000 33.52886 ? 502 LEU A CG  1 
ATOM   1116 C CD1 . LEU A 1 150 ? 2.04393   2.91495   31.06582  1.000 37.99416 ? 502 LEU A CD1 1 
ATOM   1117 C CD2 . LEU A 1 150 ? 2.62698   0.70677   30.04689  1.000 33.57966 ? 502 LEU A CD2 1 
ATOM   1118 N N   . VAL A 1 151 ? 2.56043   -2.23589  33.85910  1.000 33.14655 ? 503 VAL A N   1 
ATOM   1119 C CA  . VAL A 1 151 ? 2.94327   -2.73537  35.17769  1.000 33.92404 ? 503 VAL A CA  1 
ATOM   1120 C C   . VAL A 1 151 ? 3.74205   -1.67875  35.92920  1.000 38.04576 ? 503 VAL A C   1 
ATOM   1121 O O   . VAL A 1 151 ? 3.44375   -1.35845  37.08273  1.000 34.58985 ? 503 VAL A O   1 
ATOM   1122 C CB  . VAL A 1 151 ? 3.74136   -4.04662  35.03829  1.000 30.21041 ? 503 VAL A CB  1 
ATOM   1123 C CG1 . VAL A 1 151 ? 4.18864   -4.56357  36.40701  1.000 27.96225 ? 503 VAL A CG1 1 
ATOM   1124 C CG2 . VAL A 1 151 ? 2.90699   -5.09298  34.30569  1.000 35.58029 ? 503 VAL A CG2 1 
ATOM   1125 N N   . THR A 1 152 ? 4.78184   -1.14157  35.29066  1.000 30.81653 ? 504 THR A N   1 
ATOM   1126 C CA  . THR A 1 152 ? 5.46916   0.06411   35.73442  1.000 35.72907 ? 504 THR A CA  1 
ATOM   1127 C C   . THR A 1 152 ? 5.56445   0.99650   34.53815  1.000 41.88194 ? 504 THR A C   1 
ATOM   1128 O O   . THR A 1 152 ? 5.10818   0.66543   33.44009  1.000 36.10441 ? 504 THR A O   1 
ATOM   1129 C CB  . THR A 1 152 ? 6.86874   -0.23839  36.27985  1.000 32.41200 ? 504 THR A CB  1 
ATOM   1130 O OG1 . THR A 1 152 ? 7.71113   -0.62151  35.18387  1.000 37.51316 ? 504 THR A OG1 1 
ATOM   1131 C CG2 . THR A 1 152 ? 6.81581   -1.39910  37.29273  1.000 33.64194 ? 504 THR A CG2 1 
ATOM   1132 N N   . GLN A 1 153 ? 6.16343   2.17191   34.74134  1.000 33.21999 ? 505 GLN A N   1 
ATOM   1133 C CA  . GLN A 1 153 ? 6.38046   3.06479   33.60600  1.000 32.93063 ? 505 GLN A CA  1 
ATOM   1134 C C   . GLN A 1 153 ? 7.33294   2.47371   32.57719  1.000 35.46208 ? 505 GLN A C   1 
ATOM   1135 O O   . GLN A 1 153 ? 7.42303   3.01579   31.47008  1.000 37.86249 ? 505 GLN A O   1 
ATOM   1136 C CB  . GLN A 1 153 ? 6.90254   4.42352   34.08756  1.000 41.93283 ? 505 GLN A CB  1 
ATOM   1137 C CG  . GLN A 1 153 ? 6.63763   5.57149   33.10972  1.000 50.28458 ? 505 GLN A CG  1 
ATOM   1138 C CD  . GLN A 1 153 ? 7.01572   6.93465   33.67125  1.000 54.30483 ? 505 GLN A CD  1 
ATOM   1139 O OE1 . GLN A 1 153 ? 6.18707   7.61898   34.28704  1.000 50.88581 ? 505 GLN A OE1 1 
ATOM   1140 N NE2 . GLN A 1 153 ? 8.26412   7.33669   33.45880  1.000 40.50030 ? 505 GLN A NE2 1 
ATOM   1141 N N   . HIS A 1 154 ? 8.01600   1.36381   32.90606  1.000 30.76335 ? 506 HIS A N   1 
ATOM   1142 C CA  . HIS A 1 154 ? 8.98190   0.70260   32.03543  1.000 36.44435 ? 506 HIS A CA  1 
ATOM   1143 C C   . HIS A 1 154 ? 8.62358   -0.75748  31.77007  1.000 30.37970 ? 506 HIS A C   1 
ATOM   1144 O O   . HIS A 1 154 ? 9.49377   -1.54170  31.37339  1.000 32.09431 ? 506 HIS A O   1 
ATOM   1145 C CB  . HIS A 1 154 ? 10.39166  0.79598   32.63476  1.000 37.42583 ? 506 HIS A CB  1 
ATOM   1146 C CG  . HIS A 1 154 ? 10.87481  2.20212   32.80847  1.000 41.36558 ? 506 HIS A CG  1 
ATOM   1147 N ND1 . HIS A 1 154 ? 11.53860  2.88777   31.81335  1.000 44.12747 ? 506 HIS A ND1 1 
ATOM   1148 C CD2 . HIS A 1 154 ? 10.76872  3.06061   33.85160  1.000 44.49062 ? 506 HIS A CD2 1 
ATOM   1149 C CE1 . HIS A 1 154 ? 11.82047  4.10807   32.23591  1.000 43.30911 ? 506 HIS A CE1 1 
ATOM   1150 N NE2 . HIS A 1 154 ? 11.36577  4.23817   33.47020  1.000 46.49608 ? 506 HIS A NE2 1 
ATOM   1151 N N   . TYR A 1 155 ? 7.35861   -1.14615  31.96075  1.000 28.22005 ? 507 TYR A N   1 
ATOM   1152 C CA  . TYR A 1 155 ? 6.97376   -2.54481  31.77557  1.000 30.19962 ? 507 TYR A CA  1 
ATOM   1153 C C   . TYR A 1 155 ? 5.54682   -2.58222  31.25014  1.000 33.78678 ? 507 TYR A C   1 
ATOM   1154 O O   . TYR A 1 155 ? 4.60418   -2.29399  31.99529  1.000 31.94135 ? 507 TYR A O   1 
ATOM   1155 C CB  . TYR A 1 155 ? 7.10695   -3.32365  33.08569  1.000 38.03472 ? 507 TYR A CB  1 
ATOM   1156 C CG  . TYR A 1 155 ? 6.89968   -4.82544  32.99092  1.000 34.11035 ? 507 TYR A CG  1 
ATOM   1157 C CD1 . TYR A 1 155 ? 6.73336   -5.47171  31.76124  1.000 33.73802 ? 507 TYR A CD1 1 
ATOM   1158 C CD2 . TYR A 1 155 ? 6.87483   -5.59788  34.14342  1.000 34.62011 ? 507 TYR A CD2 1 
ATOM   1159 C CE1 . TYR A 1 155 ? 6.54972   -6.85425  31.69338  1.000 31.69095 ? 507 TYR A CE1 1 
ATOM   1160 C CE2 . TYR A 1 155 ? 6.68704   -6.96003  34.08702  1.000 35.17996 ? 507 TYR A CE2 1 
ATOM   1161 C CZ  . TYR A 1 155 ? 6.52131   -7.58314  32.87024  1.000 39.03419 ? 507 TYR A CZ  1 
ATOM   1162 O OH  . TYR A 1 155 ? 6.33045   -8.94734  32.85121  1.000 40.24382 ? 507 TYR A OH  1 
ATOM   1163 N N   . ALA A 1 156 ? 5.39564   -2.93069  29.97504  1.000 33.12398 ? 508 ALA A N   1 
ATOM   1164 C CA  . ALA A 1 156 ? 4.09894   -2.95990  29.32130  1.000 31.40804 ? 508 ALA A CA  1 
ATOM   1165 C C   . ALA A 1 156 ? 3.68149   -4.40357  29.07499  1.000 28.98426 ? 508 ALA A C   1 
ATOM   1166 O O   . ALA A 1 156 ? 4.51963   -5.28876  28.88823  1.000 29.08189 ? 508 ALA A O   1 
ATOM   1167 C CB  . ALA A 1 156 ? 4.12358   -2.16718  27.99931  1.000 26.12350 ? 508 ALA A CB  1 
ATOM   1168 N N   . LYS A 1 157 ? 2.36911   -4.63073  29.10557  1.000 30.33988 ? 509 LYS A N   1 
ATOM   1169 C CA  . LYS A 1 157 ? 1.77166   -5.92668  28.82198  1.000 25.61296 ? 509 LYS A CA  1 
ATOM   1170 C C   . LYS A 1 157 ? 0.53686   -5.72657  27.94566  1.000 27.12806 ? 509 LYS A C   1 
ATOM   1171 O O   . LYS A 1 157 ? -0.16953  -4.72698  28.06625  1.000 30.46505 ? 509 LYS A O   1 
ATOM   1172 C CB  . LYS A 1 157 ? 1.36209   -6.66583  30.11464  1.000 26.37523 ? 509 LYS A CB  1 
ATOM   1173 C CG  . LYS A 1 157 ? 2.49631   -7.27989  30.92414  1.000 29.11620 ? 509 LYS A CG  1 
ATOM   1174 C CD  . LYS A 1 157 ? 1.92901   -7.83300  32.24989  1.000 34.05896 ? 509 LYS A CD  1 
ATOM   1175 C CE  . LYS A 1 157 ? 2.95419   -8.56614  33.12700  1.000 32.35963 ? 509 LYS A CE  1 
ATOM   1176 N NZ  . LYS A 1 157 ? 3.08653   -10.00053 32.72866  1.000 41.79785 ? 509 LYS A NZ  1 
ATOM   1177 N N   . ILE A 1 158 ? 0.28756   -6.68412  27.07018  1.000 30.24076 ? 510 ILE A N   1 
ATOM   1178 C CA  . ILE A 1 158 ? -0.89814  -6.71613  26.22108  1.000 27.47659 ? 510 ILE A CA  1 
ATOM   1179 C C   . ILE A 1 158 ? -2.03493  -7.39851  26.96435  1.000 26.55738 ? 510 ILE A C   1 
ATOM   1180 O O   . ILE A 1 158 ? -1.84931  -8.45893  27.58224  1.000 28.27057 ? 510 ILE A O   1 
ATOM   1181 C CB  . ILE A 1 158 ? -0.59245  -7.46564  24.90899  1.000 29.83182 ? 510 ILE A CB  1 
ATOM   1182 C CG1 . ILE A 1 158 ? 0.64324   -6.87515  24.22753  1.000 31.64929 ? 510 ILE A CG1 1 
ATOM   1183 C CG2 . ILE A 1 158 ? -1.82413  -7.47585  23.99178  1.000 28.60328 ? 510 ILE A CG2 1 
ATOM   1184 C CD1 . ILE A 1 158 ? 1.31726   -7.85973  23.25990  1.000 30.48188 ? 510 ILE A CD1 1 
ATOM   1185 N N   . SER A 1 159 ? -3.23520  -6.83895  26.85297  1.000 26.86755 ? 511 SER A N   1 
ATOM   1186 C CA  . SER A 1 159 ? -4.41771  -7.52506  27.36890  1.000 25.03696 ? 511 SER A CA  1 
ATOM   1187 C C   . SER A 1 159 ? -5.51971  -7.49151  26.30556  1.000 27.04252 ? 511 SER A C   1 
ATOM   1188 O O   . SER A 1 159 ? -5.24047  -7.22527  25.13140  1.000 29.05311 ? 511 SER A O   1 
ATOM   1189 C CB  . SER A 1 159 ? -4.88224  -6.89091  28.68925  1.000 30.96513 ? 511 SER A CB  1 
ATOM   1190 O OG  . SER A 1 159 ? -5.84563  -7.69451  29.36446  1.000 29.63131 ? 511 SER A OG  1 
ATOM   1191 N N   . ASP A 1 160 ? -6.76170  -7.78624  26.70465  1.000 28.31143 ? 512 ASP A N   1 
ATOM   1192 C CA  . ASP A 1 160 ? -7.97056  -7.62475  25.88987  1.000 25.77782 ? 512 ASP A CA  1 
ATOM   1193 C C   . ASP A 1 160 ? -8.02562  -8.54760  24.68412  1.000 28.80586 ? 512 ASP A C   1 
ATOM   1194 O O   . ASP A 1 160 ? -7.98593  -8.09599  23.53353  1.000 29.55902 ? 512 ASP A O   1 
ATOM   1195 C CB  . ASP A 1 160 ? -8.13234  -6.17145  25.43217  1.000 29.46752 ? 512 ASP A CB  1 
ATOM   1196 C CG  . ASP A 1 160 ? -8.59957  -5.27751  26.55384  1.000 44.51727 ? 512 ASP A CG  1 
ATOM   1197 O OD1 . ASP A 1 160 ? -7.74038  -4.83402  27.34667  1.000 48.99446 ? 512 ASP A OD1 1 
ATOM   1198 O OD2 . ASP A 1 160 ? -9.82500  -5.03723  26.66221  1.000 44.02453 ? 512 ASP A OD2 1 
ATOM   1199 N N   . PHE A 1 161 ? -8.16650  -9.84136  24.94328  1.000 25.68897 ? 513 PHE A N   1 
ATOM   1200 C CA  . PHE A 1 161 ? -8.18326  -10.85707 23.90244  1.000 29.33299 ? 513 PHE A CA  1 
ATOM   1201 C C   . PHE A 1 161 ? -9.59229  -11.25386 23.49751  1.000 28.07899 ? 513 PHE A C   1 
ATOM   1202 O O   . PHE A 1 161 ? -9.78792  -12.36668 23.00054  1.000 30.67621 ? 513 PHE A O   1 
ATOM   1203 C CB  . PHE A 1 161 ? -7.39836  -12.07965 24.36999  1.000 25.35746 ? 513 PHE A CB  1 
ATOM   1204 C CG  . PHE A 1 161 ? -5.93801  -11.80217 24.53739  1.000 29.75284 ? 513 PHE A CG  1 
ATOM   1205 C CD1 . PHE A 1 161 ? -5.06470  -11.96863 23.47092  1.000 29.39317 ? 513 PHE A CD1 1 
ATOM   1206 C CD2 . PHE A 1 161 ? -5.44825  -11.32826 25.74204  1.000 29.61423 ? 513 PHE A CD2 1 
ATOM   1207 C CE1 . PHE A 1 161 ? -3.71617  -11.68401 23.61645  1.000 28.28102 ? 513 PHE A CE1 1 
ATOM   1208 C CE2 . PHE A 1 161 ? -4.09868  -11.04873 25.89423  1.000 25.59519 ? 513 PHE A CE2 1 
ATOM   1209 C CZ  . PHE A 1 161 ? -3.24319  -11.22043 24.83278  1.000 25.55311 ? 513 PHE A CZ  1 
ATOM   1210 N N   . GLY A 1 162 ? -10.57382 -10.37849 23.72134  1.000 30.16896 ? 514 GLY A N   1 
ATOM   1211 C CA  . GLY A 1 162 ? -11.95120 -10.70626 23.38488  1.000 31.14127 ? 514 GLY A CA  1 
ATOM   1212 C C   . GLY A 1 162 ? -12.16874 -11.04090 21.91880  1.000 37.63479 ? 514 GLY A C   1 
ATOM   1213 O O   . GLY A 1 162 ? -13.05778 -11.83105 21.58253  1.000 35.06788 ? 514 GLY A O   1 
ATOM   1214 N N   . LEU A 1 163 ? -11.38282 -10.44221 21.02631  1.000 33.46457 ? 515 LEU A N   1 
ATOM   1215 C CA  . LEU A 1 163 ? -11.51604 -10.68333 19.59654  1.000 31.00372 ? 515 LEU A CA  1 
ATOM   1216 C C   . LEU A 1 163 ? -10.48879 -11.67795 19.05813  1.000 30.54650 ? 515 LEU A C   1 
ATOM   1217 O O   . LEU A 1 163 ? -10.50749 -11.97183 17.85762  1.000 31.37753 ? 515 LEU A O   1 
ATOM   1218 C CB  . LEU A 1 163 ? -11.40497 -9.35082  18.82910  1.000 31.64476 ? 515 LEU A CB  1 
ATOM   1219 C CG  . LEU A 1 163 ? -12.52317 -8.33487  19.09530  1.000 32.68698 ? 515 LEU A CG  1 
ATOM   1220 C CD1 . LEU A 1 163 ? -12.33073 -7.09024  18.22423  1.000 34.84846 ? 515 LEU A CD1 1 
ATOM   1221 C CD2 . LEU A 1 163 ? -13.88677 -8.95583  18.85561  1.000 37.24226 ? 515 LEU A CD2 1 
ATOM   1222 N N   . SER A 1 164 ? -9.60492  -12.20375 19.90808  1.000 25.62769 ? 516 SER A N   1 
ATOM   1223 C CA  . SER A 1 164 ? -8.46664  -12.96286 19.41806  1.000 32.43639 ? 516 SER A CA  1 
ATOM   1224 C C   . SER A 1 164 ? -8.90916  -14.33293 18.93013  1.000 27.93437 ? 516 SER A C   1 
ATOM   1225 O O   . SER A 1 164 ? -9.93836  -14.86678 19.33874  1.000 33.34982 ? 516 SER A O   1 
ATOM   1226 C CB  . SER A 1 164 ? -7.39871  -13.11383 20.50031  1.000 30.25833 ? 516 SER A CB  1 
ATOM   1227 O OG  . SER A 1 164 ? -6.93236  -11.84853 20.89458  0.607 29.74893 ? 516 SER A OG  1 
ATOM   1228 N N   . LYS A 1 165 ? -8.11573  -14.89362 18.03129  1.000 29.41807 ? 517 LYS A N   1 
ATOM   1229 C CA  . LYS A 1 165 ? -8.43191  -16.16196 17.39206  1.000 28.14758 ? 517 LYS A CA  1 
ATOM   1230 C C   . LYS A 1 165 ? -7.15148  -16.96543 17.23702  1.000 28.58987 ? 517 LYS A C   1 
ATOM   1231 O O   . LYS A 1 165 ? -6.11304  -16.41449 16.87592  1.000 27.31002 ? 517 LYS A O   1 
ATOM   1232 C CB  . LYS A 1 165 ? -9.06765  -15.94631 16.00909  1.000 32.41571 ? 517 LYS A CB  1 
ATOM   1233 C CG  . LYS A 1 165 ? -10.35436 -15.12710 15.98982  1.000 33.53443 ? 517 LYS A CG  1 
ATOM   1234 C CD  . LYS A 1 165 ? -11.51513 -15.86246 16.66527  1.000 36.19439 ? 517 LYS A CD  1 
ATOM   1235 C CE  . LYS A 1 165 ? -12.78900 -15.02035 16.62700  1.000 44.56413 ? 517 LYS A CE  1 
ATOM   1236 N NZ  . LYS A 1 165 ? -13.98749 -15.78088 17.08630  1.000 46.36956 ? 517 LYS A NZ  1 
ATOM   1237 N N   . ALA A 1 166 ? -7.22765  -18.26386 17.50322  1.000 33.98624 ? 518 ALA A N   1 
ATOM   1238 C CA  . ALA A 1 166 ? -6.12833  -19.16581 17.18338  1.000 36.89697 ? 518 ALA A CA  1 
ATOM   1239 C C   . ALA A 1 166 ? -6.24365  -19.56287 15.71541  1.000 30.93427 ? 518 ALA A C   1 
ATOM   1240 O O   . ALA A 1 166 ? -7.32475  -19.94721 15.25659  1.000 31.43336 ? 518 ALA A O   1 
ATOM   1241 C CB  . ALA A 1 166 ? -6.16703  -20.40048 18.08720  1.000 32.55722 ? 518 ALA A CB  1 
ATOM   1242 N N   . LEU A 1 167 ? -5.15452  -19.43239 14.96868  1.000 25.52527 ? 519 LEU A N   1 
ATOM   1243 C CA  . LEU A 1 167 ? -5.24720  -19.63369 13.52913  1.000 34.69921 ? 519 LEU A CA  1 
ATOM   1244 C C   . LEU A 1 167 ? -5.33245  -21.11791 13.20019  1.000 33.78193 ? 519 LEU A C   1 
ATOM   1245 O O   . LEU A 1 167 ? -4.80077  -21.96443 13.92753  1.000 32.83255 ? 519 LEU A O   1 
ATOM   1246 C CB  . LEU A 1 167 ? -4.04211  -19.02788 12.81255  1.000 33.85650 ? 519 LEU A CB  1 
ATOM   1247 C CG  . LEU A 1 167 ? -3.95989  -17.50468 12.80601  1.000 37.10033 ? 519 LEU A CG  1 
ATOM   1248 C CD1 . LEU A 1 167 ? -2.54322  -17.07479 12.44295  1.000 40.69062 ? 519 LEU A CD1 1 
ATOM   1249 C CD2 . LEU A 1 167 ? -4.96957  -16.95052 11.82815  1.000 33.51778 ? 519 LEU A CD2 1 
ATOM   1250 N N   . ARG A 1 168 ? -6.03712  -21.42106 12.10730  1.000 30.75742 ? 520 ARG A N   1 
ATOM   1251 C CA  . ARG A 1 168 ? -6.03842  -22.76372 11.54574  1.000 35.41807 ? 520 ARG A CA  1 
ATOM   1252 C C   . ARG A 1 168 ? -4.62806  -23.16076 11.14815  1.000 33.64588 ? 520 ARG A C   1 
ATOM   1253 O O   . ARG A 1 168 ? -3.80846  -22.32287 10.77268  1.000 36.79070 ? 520 ARG A O   1 
ATOM   1254 C CB  . ARG A 1 168 ? -6.94017  -22.83485 10.31650  1.000 36.35233 ? 520 ARG A CB  1 
ATOM   1255 C CG  . ARG A 1 168 ? -8.41535  -22.70523 10.59501  1.000 43.94250 ? 520 ARG A CG  1 
ATOM   1256 C CD  . ARG A 1 168 ? -9.14210  -22.48103 9.28062   1.000 47.59432 ? 520 ARG A CD  1 
ATOM   1257 N NE  . ARG A 1 168 ? -8.77512  -23.48284 8.28293   1.000 46.88483 ? 520 ARG A NE  1 
ATOM   1258 C CZ  . ARG A 1 168 ? -9.50420  -24.55263 8.00205   1.000 38.45172 ? 520 ARG A CZ  1 
ATOM   1259 N NH1 . ARG A 1 168 ? -10.64787 -24.78754 8.62063   1.000 50.75369 ? 520 ARG A NH1 1 
ATOM   1260 N NH2 . ARG A 1 168 ? -9.08384  -25.39724 7.06580   1.000 47.25766 ? 520 ARG A NH2 1 
ATOM   1261 N N   . ALA A 1 169 ? -4.34144  -24.45901 11.21825  1.000 38.59093 ? 521 ALA A N   1 
ATOM   1262 C CA  . ALA A 1 169 ? -2.97381  -24.86900 10.93862  1.000 36.82316 ? 521 ALA A CA  1 
ATOM   1263 C C   . ALA A 1 169 ? -2.63052  -24.75886 9.45605   1.000 33.41804 ? 521 ALA A C   1 
ATOM   1264 O O   . ALA A 1 169 ? -1.44660  -24.73674 9.11351   1.000 39.96249 ? 521 ALA A O   1 
ATOM   1265 C CB  . ALA A 1 169 ? -2.72892  -26.28938 11.46070  1.000 37.93217 ? 521 ALA A CB  1 
ATOM   1266 N N   . ASP A 1 170 ? -3.62294  -24.63072 8.57454   1.000 32.79162 ? 522 ASP A N   1 
ATOM   1267 C CA  . ASP A 1 170 ? -3.36431  -24.57352 7.13930   1.000 41.67645 ? 522 ASP A CA  1 
ATOM   1268 C C   . ASP A 1 170 ? -3.49672  -23.17117 6.54779   1.000 53.35941 ? 522 ASP A C   1 
ATOM   1269 O O   . ASP A 1 170 ? -3.41577  -23.02153 5.32049   1.000 45.01603 ? 522 ASP A O   1 
ATOM   1270 C CB  . ASP A 1 170 ? -4.28635  -25.53898 6.38218   1.000 42.30025 ? 522 ASP A CB  1 
ATOM   1271 C CG  . ASP A 1 170 ? -5.76488  -25.23483 6.57909   1.000 39.60789 ? 522 ASP A CG  1 
ATOM   1272 O OD1 . ASP A 1 170 ? -6.14486  -24.52344 7.53741   1.000 43.63959 ? 522 ASP A OD1 1 
ATOM   1273 O OD2 . ASP A 1 170 ? -6.56747  -25.71891 5.76463   1.000 45.61549 ? 522 ASP A OD2 1 
ATOM   1274 N N   . GLU A 1 171 ? -3.70276  -22.14259 7.37422   1.000 42.32409 ? 523 GLU A N   1 
ATOM   1275 C CA  . GLU A 1 171 ? -3.87160  -20.78378 6.87422   1.000 47.63972 ? 523 GLU A CA  1 
ATOM   1276 C C   . GLU A 1 171 ? -3.21257  -19.80903 7.83256   1.000 41.38600 ? 523 GLU A C   1 
ATOM   1277 O O   . GLU A 1 171 ? -3.08645  -20.08410 9.02606   1.000 40.78357 ? 523 GLU A O   1 
ATOM   1278 C CB  . GLU A 1 171 ? -5.35206  -20.41208 6.69841   1.000 36.72951 ? 523 GLU A CB  1 
ATOM   1279 C CG  . GLU A 1 171 ? -6.06819  -21.17675 5.59890   1.000 46.12366 ? 523 GLU A CG  1 
ATOM   1280 C CD  . GLU A 1 171 ? -5.60855  -20.79194 4.19603   1.000 54.03767 ? 523 GLU A CD  1 
ATOM   1281 O OE1 . GLU A 1 171 ? -4.65801  -19.99054 4.06038   1.000 60.71755 ? 523 GLU A OE1 1 
ATOM   1282 O OE2 . GLU A 1 171 ? -6.21065  -21.29240 3.21943   1.000 65.45949 ? 523 GLU A OE2 1 
ATOM   1283 N N   . ASN A 1 172 ? -2.78108  -18.66390 7.30623   1.000 41.89250 ? 524 ASN A N   1 
ATOM   1284 C CA  . ASN A 1 172 ? -2.14684  -17.66707 8.15663   1.000 44.60834 ? 524 ASN A CA  1 
ATOM   1285 C C   . ASN A 1 172 ? -3.07510  -16.49162 8.45702   1.000 38.83343 ? 524 ASN A C   1 
ATOM   1286 O O   . ASN A 1 172 ? -2.61786  -15.46149 8.96556   1.000 33.91404 ? 524 ASN A O   1 
ATOM   1287 C CB  . ASN A 1 172 ? -0.81264  -17.20392 7.54986   1.000 42.78557 ? 524 ASN A CB  1 
ATOM   1288 C CG  . ASN A 1 172 ? -0.97542  -16.39575 6.27112   1.000 45.67844 ? 524 ASN A CG  1 
ATOM   1289 O OD1 . ASN A 1 172 ? -2.01182  -16.44220 5.60456   1.000 53.91687 ? 524 ASN A OD1 1 
ATOM   1290 N ND2 . ASN A 1 172 ? 0.07183   -15.66349 5.91203   1.000 53.07337 ? 524 ASN A ND2 1 
ATOM   1291 N N   . TYR A 1 173 ? -4.37902  -16.65545 8.21145   1.000 38.41812 ? 525 TYR A N   1 
ATOM   1292 C CA  . TYR A 1 173 ? -5.35417  -15.60410 8.43311   1.000 35.20681 ? 525 TYR A CA  1 
ATOM   1293 C C   . TYR A 1 173 ? -6.66167  -16.20523 8.93239   1.000 39.95573 ? 525 TYR A C   1 
ATOM   1294 O O   . TYR A 1 173 ? -6.98577  -17.36338 8.64516   1.000 38.78374 ? 525 TYR A O   1 
ATOM   1295 C CB  . TYR A 1 173 ? -5.61253  -14.79517 7.15413   1.000 41.78823 ? 525 TYR A CB  1 
ATOM   1296 C CG  . TYR A 1 173 ? -6.31280  -15.58542 6.07584   1.000 45.83185 ? 525 TYR A CG  1 
ATOM   1297 C CD1 . TYR A 1 173 ? -5.58804  -16.35572 5.16359   1.000 44.95583 ? 525 TYR A CD1 1 
ATOM   1298 C CD2 . TYR A 1 173 ? -7.69984  -15.57073 5.97183   1.000 41.95448 ? 525 TYR A CD2 1 
ATOM   1299 C CE1 . TYR A 1 173 ? -6.23466  -17.09263 4.17677   1.000 51.63549 ? 525 TYR A CE1 1 
ATOM   1300 C CE2 . TYR A 1 173 ? -8.34892  -16.29552 4.99204   1.000 52.28722 ? 525 TYR A CE2 1 
ATOM   1301 C CZ  . TYR A 1 173 ? -7.61745  -17.05140 4.09809   1.000 48.94109 ? 525 TYR A CZ  1 
ATOM   1302 O OH  . TYR A 1 173 ? -8.28556  -17.76419 3.13485   1.000 55.20395 ? 525 TYR A OH  1 
ATOM   1303 N N   . TYR A 1 174 ? -7.40459  -15.39962 9.68809   1.000 31.82839 ? 526 TYR A N   1 
ATOM   1304 C CA  . TYR A 1 174 ? -8.76972  -15.70735 10.10278  1.000 35.30036 ? 526 TYR A CA  1 
ATOM   1305 C C   . TYR A 1 174 ? -9.73661  -14.90962 9.24338   1.000 38.44498 ? 526 TYR A C   1 
ATOM   1306 O O   . TYR A 1 174 ? -9.54294  -13.70814 9.02725   1.000 33.36408 ? 526 TYR A O   1 
ATOM   1307 C CB  . TYR A 1 174 ? -8.99179  -15.38130 11.58351  1.000 32.14236 ? 526 TYR A CB  1 
ATOM   1308 C CG  . TYR A 1 174 ? -10.43988 -15.41219 12.04316  1.000 43.21033 ? 526 TYR A CG  1 
ATOM   1309 C CD1 . TYR A 1 174 ? -11.08539 -16.62022 12.29288  1.000 44.15232 ? 526 TYR A CD1 1 
ATOM   1310 C CD2 . TYR A 1 174 ? -11.15645 -14.23006 12.25069  1.000 39.75065 ? 526 TYR A CD2 1 
ATOM   1311 C CE1 . TYR A 1 174 ? -12.40027 -16.65589 12.71301  1.000 44.25072 ? 526 TYR A CE1 1 
ATOM   1312 C CE2 . TYR A 1 174 ? -12.48570 -14.25941 12.67285  1.000 41.67197 ? 526 TYR A CE2 1 
ATOM   1313 C CZ  . TYR A 1 174 ? -13.09391 -15.47717 12.90651  1.000 47.46666 ? 526 TYR A CZ  1 
ATOM   1314 O OH  . TYR A 1 174 ? -14.40245 -15.53250 13.33039  1.000 56.27853 ? 526 TYR A OH  1 
ATOM   1315 N N   . LYS A 1 175 ? -10.77811 -15.57520 8.76669   1.000 35.75621 ? 527 LYS A N   1 
ATOM   1316 C CA  . LYS A 1 175 ? -11.77951 -14.96530 7.90481   1.000 36.33255 ? 527 LYS A CA  1 
ATOM   1317 C C   . LYS A 1 175 ? -13.03712 -14.75948 8.73266   1.000 42.50508 ? 527 LYS A C   1 
ATOM   1318 O O   . LYS A 1 175 ? -13.68366 -15.73307 9.12875   1.000 41.04622 ? 527 LYS A O   1 
ATOM   1319 C CB  . LYS A 1 175 ? -12.05385 -15.85635 6.69598   1.000 48.44131 ? 527 LYS A CB  1 
ATOM   1320 C CG  . LYS A 1 175 ? -13.16305 -15.36575 5.78168   1.000 51.32597 ? 527 LYS A CG  1 
ATOM   1321 C CD  . LYS A 1 175 ? -12.71624 -14.15256 4.98695   1.000 49.15890 ? 527 LYS A CD  1 
ATOM   1322 C CE  . LYS A 1 175 ? -13.77506 -13.74103 3.98284   1.000 55.41785 ? 527 LYS A CE  1 
ATOM   1323 N NZ  . LYS A 1 175 ? -15.04848 -13.41033 4.67870   1.000 64.30453 ? 527 LYS A NZ  1 
ATOM   1324 N N   . ALA A 1 176 ? -13.37833 -13.50168 9.00340   1.000 42.13884 ? 528 ALA A N   1 
ATOM   1325 C CA  . ALA A 1 176 ? -14.58375 -13.19025 9.76849   1.000 38.76336 ? 528 ALA A CA  1 
ATOM   1326 C C   . ALA A 1 176 ? -15.82647 -13.32322 8.89765   1.000 47.18606 ? 528 ALA A C   1 
ATOM   1327 O O   . ALA A 1 176 ? -16.92393 -13.56068 9.40369   1.000 52.64612 ? 528 ALA A O   1 
ATOM   1328 C CB  . ALA A 1 176 ? -14.49673 -11.77337 10.37310  1.000 40.85231 ? 528 ALA A CB  1 
ATOM   1329 N N   . PRO A 1 183 ? -13.33275 -1.65495  15.43253  1.000 41.96407 ? 535 PRO A N   1 
ATOM   1330 C CA  . PRO A 1 183 ? -12.23097 -0.69450  15.57462  1.000 43.15728 ? 535 PRO A CA  1 
ATOM   1331 C C   . PRO A 1 183 ? -11.55108 -0.38274  14.23867  1.000 39.65558 ? 535 PRO A C   1 
ATOM   1332 O O   . PRO A 1 183 ? -10.34549 -0.61571  14.08545  1.000 34.14978 ? 535 PRO A O   1 
ATOM   1333 C CB  . PRO A 1 183 ? -11.27574 -1.40816  16.52871  1.000 50.26813 ? 535 PRO A CB  1 
ATOM   1334 C CG  . PRO A 1 183 ? -11.47625 -2.87123  16.21133  1.000 35.97803 ? 535 PRO A CG  1 
ATOM   1335 C CD  . PRO A 1 183 ? -12.95468 -3.00757  15.88807  1.000 47.97469 ? 535 PRO A CD  1 
ATOM   1336 N N   . VAL A 1 184 ? -12.33214 0.17192   13.30930  1.000 34.04369 ? 536 VAL A N   1 
ATOM   1337 C CA  . VAL A 1 184 ? -11.89200 0.33803   11.92488  1.000 39.48801 ? 536 VAL A CA  1 
ATOM   1338 C C   . VAL A 1 184 ? -10.62767 1.18482   11.84338  1.000 39.07521 ? 536 VAL A C   1 
ATOM   1339 O O   . VAL A 1 184 ? -9.77091  0.95428   10.98212  1.000 31.89886 ? 536 VAL A O   1 
ATOM   1340 C CB  . VAL A 1 184 ? -13.04073 0.92450   11.07819  1.000 45.65613 ? 536 VAL A CB  1 
ATOM   1341 C CG1 . VAL A 1 184 ? -12.53394 1.63684   9.82772   1.000 44.20702 ? 536 VAL A CG1 1 
ATOM   1342 C CG2 . VAL A 1 184 ? -14.00015 -0.18669  10.68046  1.000 51.70293 ? 536 VAL A CG2 1 
ATOM   1343 N N   . LYS A 1 185 ? -10.48168 2.17470   12.73363  1.000 33.21354 ? 537 LYS A N   1 
ATOM   1344 C CA  . LYS A 1 185 ? -9.31986  3.04591   12.64498  1.000 31.16758 ? 537 LYS A CA  1 
ATOM   1345 C C   . LYS A 1 185 ? -8.01093  2.30716   12.90364  1.000 28.47516 ? 537 LYS A C   1 
ATOM   1346 O O   . LYS A 1 185 ? -6.94799  2.85639   12.60634  1.000 27.64553 ? 537 LYS A O   1 
ATOM   1347 C CB  . LYS A 1 185 ? -9.46114  4.22295   13.61720  1.000 32.05522 ? 537 LYS A CB  1 
ATOM   1348 C CG  . LYS A 1 185 ? -10.49460 5.27289   13.18657  1.000 31.76663 ? 537 LYS A CG  1 
ATOM   1349 C CD  . LYS A 1 185 ? -10.71603 6.27471   14.32604  1.000 43.26282 ? 537 LYS A CD  1 
ATOM   1350 C CE  . LYS A 1 185 ? -11.58673 7.43608   13.89943  1.000 35.44503 ? 537 LYS A CE  1 
ATOM   1351 N NZ  . LYS A 1 185 ? -12.63058 6.95511   12.97156  1.000 46.10674 ? 537 LYS A NZ  1 
ATOM   1352 N N   . TRP A 1 186 ? -8.06512  1.08213   13.42591  1.000 26.22431 ? 538 TRP A N   1 
ATOM   1353 C CA  . TRP A 1 186 ? -6.88687  0.25614   13.65782  1.000 31.90744 ? 538 TRP A CA  1 
ATOM   1354 C C   . TRP A 1 186 ? -6.74441  -0.86830  12.64652  1.000 31.51534 ? 538 TRP A C   1 
ATOM   1355 O O   . TRP A 1 186 ? -5.77410  -1.63152  12.72001  1.000 29.29594 ? 538 TRP A O   1 
ATOM   1356 C CB  . TRP A 1 186 ? -6.92533  -0.33834  15.07449  1.000 26.40142 ? 538 TRP A CB  1 
ATOM   1357 C CG  . TRP A 1 186 ? -6.61883  0.67468   16.13025  1.000 27.62493 ? 538 TRP A CG  1 
ATOM   1358 C CD1 . TRP A 1 186 ? -5.39804  0.91772   16.71150  1.000 26.08857 ? 538 TRP A CD1 1 
ATOM   1359 C CD2 . TRP A 1 186 ? -7.54042  1.60267   16.72741  1.000 25.41328 ? 538 TRP A CD2 1 
ATOM   1360 N NE1 . TRP A 1 186 ? -5.50926  1.94730   17.62552  1.000 25.24993 ? 538 TRP A NE1 1 
ATOM   1361 C CE2 . TRP A 1 186 ? -6.81235  2.37442   17.65961  1.000 26.97730 ? 538 TRP A CE2 1 
ATOM   1362 C CE3 . TRP A 1 186 ? -8.91715  1.84019   16.57451  1.000 28.01737 ? 538 TRP A CE3 1 
ATOM   1363 C CZ2 . TRP A 1 186 ? -7.40294  3.37809   18.42554  1.000 33.35573 ? 538 TRP A CZ2 1 
ATOM   1364 C CZ3 . TRP A 1 186 ? -9.50326  2.84689   17.33368  1.000 38.68035 ? 538 TRP A CZ3 1 
ATOM   1365 C CH2 . TRP A 1 186 ? -8.74353  3.60720   18.24179  1.000 33.64745 ? 538 TRP A CH2 1 
ATOM   1366 N N   . TYR A 1 187 ? -7.66400  -0.98728  11.70066  1.000 30.77703 ? 539 TYR A N   1 
ATOM   1367 C CA  . TYR A 1 187 ? -7.72774  -2.16918  10.85350  1.000 31.16674 ? 539 TYR A CA  1 
ATOM   1368 C C   . TYR A 1 187 ? -7.00843  -1.94708  9.52950   1.000 33.54564 ? 539 TYR A C   1 
ATOM   1369 O O   . TYR A 1 187 ? -7.09198  -0.86941  8.93340   1.000 30.61695 ? 539 TYR A O   1 
ATOM   1370 C CB  . TYR A 1 187 ? -9.18799  -2.56848  10.62464  1.000 33.56071 ? 539 TYR A CB  1 
ATOM   1371 C CG  . TYR A 1 187 ? -9.70676  -3.43982  11.75636  1.000 35.49858 ? 539 TYR A CG  1 
ATOM   1372 C CD1 . TYR A 1 187 ? -8.89206  -3.72409  12.85528  1.000 34.34706 ? 539 TYR A CD1 1 
ATOM   1373 C CD2 . TYR A 1 187 ? -10.98126 -3.99044  11.72603  1.000 37.24734 ? 539 TYR A CD2 1 
ATOM   1374 C CE1 . TYR A 1 187 ? -9.33371  -4.54042  13.90196  1.000 31.15589 ? 539 TYR A CE1 1 
ATOM   1375 C CE2 . TYR A 1 187 ? -11.44208 -4.80955  12.77390  1.000 36.72160 ? 539 TYR A CE2 1 
ATOM   1376 C CZ  . TYR A 1 187 ? -10.61361 -5.07914  13.85357  1.000 40.25159 ? 539 TYR A CZ  1 
ATOM   1377 O OH  . TYR A 1 187 ? -11.05208 -5.88444  14.89894  1.000 38.20627 ? 539 TYR A OH  1 
ATOM   1378 N N   . ALA A 1 188 ? -6.29387  -2.97694  9.07572   1.000 31.14398 ? 540 ALA A N   1 
ATOM   1379 C CA  . ALA A 1 188 ? -5.60259  -2.90625  7.79831   1.000 29.71544 ? 540 ALA A CA  1 
ATOM   1380 C C   . ALA A 1 188 ? -6.60323  -2.99254  6.64807   1.000 31.54165 ? 540 ALA A C   1 
ATOM   1381 O O   . ALA A 1 188 ? -7.74271  -3.43086  6.83890   1.000 27.55243 ? 540 ALA A O   1 
ATOM   1382 C CB  . ALA A 1 188 ? -4.58480  -4.03793  7.68464   1.000 26.95457 ? 540 ALA A CB  1 
ATOM   1383 N N   . PRO A 1 189 ? -6.18214  -2.59920  5.43353   1.000 30.34457 ? 541 PRO A N   1 
ATOM   1384 C CA  . PRO A 1 189 ? -7.10456  -2.63997  4.28310   1.000 30.77914 ? 541 PRO A CA  1 
ATOM   1385 C C   . PRO A 1 189 ? -7.72780  -3.99861  4.03988   1.000 39.20050 ? 541 PRO A C   1 
ATOM   1386 O O   . PRO A 1 189 ? -8.93939  -4.07491  3.77405   1.000 41.13507 ? 541 PRO A O   1 
ATOM   1387 C CB  . PRO A 1 189 ? -6.21027  -2.21910  3.10831   1.000 37.47172 ? 541 PRO A CB  1 
ATOM   1388 C CG  . PRO A 1 189 ? -5.16083  -1.36129  3.73256   1.000 33.82239 ? 541 PRO A CG  1 
ATOM   1389 C CD  . PRO A 1 189 ? -4.90537  -1.94724  5.09122   1.000 26.78395 ? 541 PRO A CD  1 
ATOM   1390 N N   . GLU A 1 190 ? -6.94175  -5.07741  4.12428   1.000 31.81602 ? 542 GLU A N   1 
ATOM   1391 C CA  . GLU A 1 190 ? -7.49449  -6.40505  3.87656   1.000 39.39818 ? 542 GLU A CA  1 
ATOM   1392 C C   . GLU A 1 190 ? -8.51653  -6.82498  4.93149   1.000 37.74516 ? 542 GLU A C   1 
ATOM   1393 O O   . GLU A 1 190 ? -9.36578  -7.67179  4.64186   1.000 34.22743 ? 542 GLU A O   1 
ATOM   1394 C CB  . GLU A 1 190 ? -6.38007  -7.44087  3.80029   1.000 32.69020 ? 542 GLU A CB  1 
ATOM   1395 C CG  . GLU A 1 190 ? -5.70477  -7.72494  5.13722   1.000 35.15295 ? 542 GLU A CG  1 
ATOM   1396 C CD  . GLU A 1 190 ? -4.55363  -6.77393  5.45269   1.000 31.37979 ? 542 GLU A CD  1 
ATOM   1397 O OE1 . GLU A 1 190 ? -4.28931  -5.83488  4.66863   1.000 34.42749 ? 542 GLU A OE1 1 
ATOM   1398 O OE2 . GLU A 1 190 ? -3.87868  -6.98473  6.47826   1.000 30.29938 ? 542 GLU A OE2 1 
ATOM   1399 N N   . CYS A 1 191 ? -8.45516  -6.26908  6.14727   1.000 31.57334 ? 543 CYS A N   1 
ATOM   1400 C CA  . CYS A 1 191 ? -9.52146  -6.51443  7.11689   1.000 32.28171 ? 543 CYS A CA  1 
ATOM   1401 C C   . CYS A 1 191 ? -10.81207 -5.82288  6.69406   1.000 36.89834 ? 543 CYS A C   1 
ATOM   1402 O O   . CYS A 1 191 ? -11.89397 -6.41907  6.74967   1.000 34.11277 ? 543 CYS A O   1 
ATOM   1403 C CB  . CYS A 1 191 ? -9.10754  -6.04172  8.51144   1.000 27.53036 ? 543 CYS A CB  1 
ATOM   1404 S SG  . CYS A 1 191 ? -7.43980  -6.48613  8.97714   1.000 32.42658 ? 543 CYS A SG  1 
ATOM   1405 N N   . ILE A 1 192 ? -10.71717 -4.55148  6.29135   1.000 36.65066 ? 544 ILE A N   1 
ATOM   1406 C CA  . ILE A 1 192 ? -11.89497 -3.80615  5.85504   1.000 35.94217 ? 544 ILE A CA  1 
ATOM   1407 C C   . ILE A 1 192 ? -12.44853 -4.38008  4.55547   1.000 35.66269 ? 544 ILE A C   1 
ATOM   1408 O O   . ILE A 1 192 ? -13.66758 -4.53472  4.39297   1.000 39.18543 ? 544 ILE A O   1 
ATOM   1409 C CB  . ILE A 1 192 ? -11.54836 -2.31024  5.69391   1.000 41.82378 ? 544 ILE A CB  1 
ATOM   1410 C CG1 . ILE A 1 192 ? -10.85712 -1.75626  6.94571   1.000 39.83243 ? 544 ILE A CG1 1 
ATOM   1411 C CG2 . ILE A 1 192 ? -12.79651 -1.50979  5.39334   1.000 46.54578 ? 544 ILE A CG2 1 
ATOM   1412 C CD1 . ILE A 1 192 ? -11.71219 -1.80009  8.19057   1.000 35.17906 ? 544 ILE A CD1 1 
ATOM   1413 N N   . ASN A 1 193 ? -11.56781 -4.68775  3.60004   1.000 41.01460 ? 545 ASN A N   1 
ATOM   1414 C CA  . ASN A 1 193 ? -12.02302 -5.08156  2.26815   1.000 46.43021 ? 545 ASN A CA  1 
ATOM   1415 C C   . ASN A 1 193 ? -12.42548 -6.55193  2.20053   1.000 45.10698 ? 545 ASN A C   1 
ATOM   1416 O O   . ASN A 1 193 ? -13.39385 -6.89615  1.51216   1.000 40.72112 ? 545 ASN A O   1 
ATOM   1417 C CB  . ASN A 1 193 ? -10.93331 -4.78264  1.23456   1.000 43.70495 ? 545 ASN A CB  1 
ATOM   1418 C CG  . ASN A 1 193 ? -10.68002 -3.29902  1.07240   1.000 40.18692 ? 545 ASN A CG  1 
ATOM   1419 O OD1 . ASN A 1 193 ? -11.57384 -2.48430  1.27811   1.000 50.52712 ? 545 ASN A OD1 1 
ATOM   1420 N ND2 . ASN A 1 193 ? -9.45741  -2.94144  0.70282   1.000 41.16671 ? 545 ASN A ND2 1 
ATOM   1421 N N   . TYR A 1 194 ? -11.70827 -7.43327  2.90677   1.000 35.90037 ? 546 TYR A N   1 
ATOM   1422 C CA  . TYR A 1 194 ? -11.89784 -8.86831  2.74528   1.000 36.27327 ? 546 TYR A CA  1 
ATOM   1423 C C   . TYR A 1 194 ? -12.14760 -9.62359  4.04263   1.000 35.25340 ? 546 TYR A C   1 
ATOM   1424 O O   . TYR A 1 194 ? -12.26811 -10.85277 4.00087   1.000 38.37962 ? 546 TYR A O   1 
ATOM   1425 C CB  . TYR A 1 194 ? -10.68572 -9.48766  2.03560   1.000 35.65500 ? 546 TYR A CB  1 
ATOM   1426 C CG  . TYR A 1 194 ? -10.36130 -8.82898  0.71330   1.000 44.10313 ? 546 TYR A CG  1 
ATOM   1427 C CD1 . TYR A 1 194 ? -11.25348 -8.89382  -0.34844  1.000 49.21474 ? 546 TYR A CD1 1 
ATOM   1428 C CD2 . TYR A 1 194 ? -9.16345  -8.14845  0.52448   1.000 52.74440 ? 546 TYR A CD2 1 
ATOM   1429 C CE1 . TYR A 1 194 ? -10.96694 -8.30064  -1.55916  1.000 57.78830 ? 546 TYR A CE1 1 
ATOM   1430 C CE2 . TYR A 1 194 ? -8.86373  -7.54924  -0.68862  1.000 47.85454 ? 546 TYR A CE2 1 
ATOM   1431 C CZ  . TYR A 1 194 ? -9.77485  -7.62842  -1.72874  1.000 64.55055 ? 546 TYR A CZ  1 
ATOM   1432 O OH  . TYR A 1 194 ? -9.50102  -7.04300  -2.94733  1.000 61.73217 ? 546 TYR A OH  1 
ATOM   1433 N N   . TYR A 1 195 ? -12.23459 -8.93592  5.18161   1.000 35.26074 ? 547 TYR A N   1 
ATOM   1434 C CA  . TYR A 1 195 ? -12.50288 -9.57183  6.47468   1.000 37.11470 ? 547 TYR A CA  1 
ATOM   1435 C C   . TYR A 1 195 ? -11.44236 -10.61022 6.82486   1.000 41.11725 ? 547 TYR A C   1 
ATOM   1436 O O   . TYR A 1 195 ? -11.74047 -11.61092 7.48588   1.000 40.33334 ? 547 TYR A O   1 
ATOM   1437 C CB  . TYR A 1 195 ? -13.89488 -10.22396 6.51030   1.000 41.42217 ? 547 TYR A CB  1 
ATOM   1438 C CG  . TYR A 1 195 ? -15.06405 -9.27468  6.58419   1.000 51.58151 ? 547 TYR A CG  1 
ATOM   1439 C CD1 . TYR A 1 195 ? -14.88932 -7.89989  6.46103   1.000 52.90029 ? 547 TYR A CD1 1 
ATOM   1440 C CD2 . TYR A 1 195 ? -16.35531 -9.75599  6.78948   1.000 57.24751 ? 547 TYR A CD2 1 
ATOM   1441 C CE1 . TYR A 1 195 ? -15.97138 -7.03082  6.52789   1.000 55.78089 ? 547 TYR A CE1 1 
ATOM   1442 C CE2 . TYR A 1 195 ? -17.44181 -8.89597  6.86160   1.000 66.85247 ? 547 TYR A CE2 1 
ATOM   1443 C CZ  . TYR A 1 195 ? -17.24529 -7.53308  6.73021   1.000 69.64004 ? 547 TYR A CZ  1 
ATOM   1444 O OH  . TYR A 1 195 ? -18.32347 -6.67461  6.80462   1.000 62.18194 ? 547 TYR A OH  1 
ATOM   1445 N N   . LYS A 1 196 ? -10.20316 -10.38691 6.38509   1.000 32.24281 ? 548 LYS A N   1 
ATOM   1446 C CA  . LYS A 1 196 ? -9.10980  -11.32800 6.57698   1.000 35.08515 ? 548 LYS A CA  1 
ATOM   1447 C C   . LYS A 1 196 ? -8.14106  -10.76093 7.60632   1.000 35.85639 ? 548 LYS A C   1 
ATOM   1448 O O   . LYS A 1 196 ? -7.52954  -9.71160  7.37563   1.000 32.05242 ? 548 LYS A O   1 
ATOM   1449 C CB  . LYS A 1 196 ? -8.38029  -11.60265 5.25715   1.000 39.03132 ? 548 LYS A CB  1 
ATOM   1450 C CG  . LYS A 1 196 ? -9.23793  -12.23912 4.18392   1.000 42.60345 ? 548 LYS A CG  1 
ATOM   1451 C CD  . LYS A 1 196 ? -8.53625  -12.23223 2.83014   1.000 41.24565 ? 548 LYS A CD  1 
ATOM   1452 C CE  . LYS A 1 196 ? -7.22377  -12.98452 2.85850   1.000 49.73707 ? 548 LYS A CE  1 
ATOM   1453 N NZ  . LYS A 1 196 ? -6.91710  -13.56915 1.51973   1.000 50.71693 ? 548 LYS A NZ  1 
ATOM   1454 N N   . PHE A 1 197 ? -7.97514  -11.47454 8.71662   1.000 32.68773 ? 549 PHE A N   1 
ATOM   1455 C CA  . PHE A 1 197 ? -7.16777  -11.02635 9.84602   1.000 28.21698 ? 549 PHE A CA  1 
ATOM   1456 C C   . PHE A 1 197 ? -5.95653  -11.93298 10.01888  1.000 31.81590 ? 549 PHE A C   1 
ATOM   1457 O O   . PHE A 1 197 ? -6.09560  -13.14748 10.20010  1.000 32.12710 ? 549 PHE A O   1 
ATOM   1458 C CB  . PHE A 1 197 ? -8.01993  -11.00270 11.11240  1.000 28.98446 ? 549 PHE A CB  1 
ATOM   1459 C CG  . PHE A 1 197 ? -9.11486  -9.97413  11.06316  1.000 33.08950 ? 549 PHE A CG  1 
ATOM   1460 C CD1 . PHE A 1 197 ? -10.33559 -10.26748 10.46561  1.000 36.13501 ? 549 PHE A CD1 1 
ATOM   1461 C CD2 . PHE A 1 197 ? -8.91649  -8.70741  11.58604  1.000 37.35357 ? 549 PHE A CD2 1 
ATOM   1462 C CE1 . PHE A 1 197 ? -11.34307 -9.32882  10.40830  1.000 30.50722 ? 549 PHE A CE1 1 
ATOM   1463 C CE2 . PHE A 1 197 ? -9.92596  -7.75449  11.53697  1.000 32.69159 ? 549 PHE A CE2 1 
ATOM   1464 C CZ  . PHE A 1 197 ? -11.13989 -8.06798  10.94039  1.000 31.54041 ? 549 PHE A CZ  1 
ATOM   1465 N N   . SER A 1 198 ? -4.77128  -11.34896 9.96165   1.000 29.80898 ? 550 SER A N   1 
ATOM   1466 C CA  . SER A 1 198 ? -3.54824  -12.11889 10.07339  1.000 37.02047 ? 550 SER A CA  1 
ATOM   1467 C C   . SER A 1 198 ? -2.64785  -11.43168 11.07945  1.000 31.76530 ? 550 SER A C   1 
ATOM   1468 O O   . SER A 1 198 ? -2.94797  -10.33079 11.55828  1.000 32.44343 ? 550 SER A O   1 
ATOM   1469 C CB  . SER A 1 198 ? -2.84290  -12.22930 8.72407   1.000 31.43177 ? 550 SER A CB  1 
ATOM   1470 O OG  . SER A 1 198 ? -2.46818  -10.92912 8.28518   1.000 32.33967 ? 550 SER A OG  1 
ATOM   1471 N N   . SER A 1 199 ? -1.51907  -12.07875 11.38964  1.000 28.77049 ? 551 SER A N   1 
ATOM   1472 C CA  . SER A 1 199 ? -0.50793  -11.38663 12.17962  1.000 28.78478 ? 551 SER A CA  1 
ATOM   1473 C C   . SER A 1 199 ? -0.05277  -10.11783 11.46824  1.000 25.55550 ? 551 SER A C   1 
ATOM   1474 O O   . SER A 1 199 ? 0.22362   -9.10875  12.12991  1.000 27.14330 ? 551 SER A O   1 
ATOM   1475 C CB  . SER A 1 199 ? 0.67563   -12.31258 12.48648  1.000 31.65541 ? 551 SER A CB  1 
ATOM   1476 O OG  . SER A 1 199 ? 0.34293   -13.24168 13.51491  1.000 28.63053 ? 551 SER A OG  1 
ATOM   1477 N N   . LYS A 1 200 ? -0.02758  -10.13092 10.11991  1.000 27.06926 ? 552 LYS A N   1 
ATOM   1478 C CA  . LYS A 1 200 ? 0.29649   -8.91940  9.36176   1.000 26.12779 ? 552 LYS A CA  1 
ATOM   1479 C C   . LYS A 1 200 ? -0.72417  -7.81864  9.60251   1.000 27.17102 ? 552 LYS A C   1 
ATOM   1480 O O   . LYS A 1 200 ? -0.37758  -6.62629  9.58966   1.000 27.77045 ? 552 LYS A O   1 
ATOM   1481 C CB  . LYS A 1 200 ? 0.37761   -9.21788  7.86478   1.000 32.94272 ? 552 LYS A CB  1 
ATOM   1482 C CG  . LYS A 1 200 ? 1.53328   -10.11381 7.44725   1.000 35.02629 ? 552 LYS A CG  1 
ATOM   1483 C CD  . LYS A 1 200 ? 2.88926   -9.48619  7.73651   1.000 31.54843 ? 552 LYS A CD  1 
ATOM   1484 C CE  . LYS A 1 200 ? 3.99305   -10.28794 7.05879   1.000 42.90238 ? 552 LYS A CE  1 
ATOM   1485 N NZ  . LYS A 1 200 ? 3.88771   -10.22693 5.55980   1.000 42.67544 ? 552 LYS A NZ  1 
ATOM   1486 N N   . SER A 1 201 ? -2.00235  -8.18042  9.76793   1.000 27.46082 ? 553 SER A N   1 
ATOM   1487 C CA  . SER A 1 201 ? -2.96767  -7.13290  10.06753  1.000 26.44393 ? 553 SER A CA  1 
ATOM   1488 C C   . SER A 1 201 ? -2.77175  -6.58798  11.48004  1.000 28.19145 ? 553 SER A C   1 
ATOM   1489 O O   . SER A 1 201 ? -2.96972  -5.38827  11.70519  1.000 22.79287 ? 553 SER A O   1 
ATOM   1490 C CB  . SER A 1 201 ? -4.40028  -7.62993  9.80775   1.000 29.47387 ? 553 SER A CB  1 
ATOM   1491 O OG  . SER A 1 201 ? -4.89437  -8.52025  10.78349  1.000 40.78699 ? 553 SER A OG  1 
ATOM   1492 N N   . ASP A 1 202 ? -2.32914  -7.42765  12.42903  1.000 26.99602 ? 554 ASP A N   1 
ATOM   1493 C CA  . ASP A 1 202 ? -1.91630  -6.91852  13.73787  1.000 29.02989 ? 554 ASP A CA  1 
ATOM   1494 C C   . ASP A 1 202 ? -0.73689  -5.95271  13.62636  1.000 28.75129 ? 554 ASP A C   1 
ATOM   1495 O O   . ASP A 1 202 ? -0.63959  -4.99355  14.41223  1.000 24.08974 ? 554 ASP A O   1 
ATOM   1496 C CB  . ASP A 1 202 ? -1.54956  -8.07829  14.67847  1.000 25.94621 ? 554 ASP A CB  1 
ATOM   1497 C CG  . ASP A 1 202 ? -2.75872  -8.80788  15.24022  1.000 36.29156 ? 554 ASP A CG  1 
ATOM   1498 O OD1 . ASP A 1 202 ? -3.90122  -8.27020  15.19347  1.000 28.83139 ? 554 ASP A OD1 1 
ATOM   1499 O OD2 . ASP A 1 202 ? -2.54317  -9.93880  15.76289  1.000 27.85577 ? 554 ASP A OD2 1 
ATOM   1500 N N   . VAL A 1 203 ? 0.16817   -6.17616  12.66106  1.000 25.79690 ? 555 VAL A N   1 
ATOM   1501 C CA  . VAL A 1 203 ? 1.28423   -5.25004  12.47124  1.000 30.54710 ? 555 VAL A CA  1 
ATOM   1502 C C   . VAL A 1 203 ? 0.77542   -3.87300  12.05843  1.000 25.86244 ? 555 VAL A C   1 
ATOM   1503 O O   . VAL A 1 203 ? 1.27095   -2.84600  12.53609  1.000 25.63781 ? 555 VAL A O   1 
ATOM   1504 C CB  . VAL A 1 203 ? 2.28994   -5.80008  11.43884  1.000 27.36958 ? 555 VAL A CB  1 
ATOM   1505 C CG1 . VAL A 1 203 ? 3.34769   -4.73990  11.12073  1.000 24.77814 ? 555 VAL A CG1 1 
ATOM   1506 C CG2 . VAL A 1 203 ? 2.94301   -7.09722  11.94238  1.000 24.95419 ? 555 VAL A CG2 1 
ATOM   1507 N N   . TRP A 1 204 ? -0.20821  -3.82499  11.14706  1.000 23.47593 ? 556 TRP A N   1 
ATOM   1508 C CA  . TRP A 1 204 ? -0.81444  -2.54185  10.79569  1.000 22.47260 ? 556 TRP A CA  1 
ATOM   1509 C C   . TRP A 1 204 ? -1.34615  -1.83813  12.03298  1.000 23.28335 ? 556 TRP A C   1 
ATOM   1510 O O   . TRP A 1 204 ? -1.12712  -0.63362  12.21821  1.000 22.18880 ? 556 TRP A O   1 
ATOM   1511 C CB  . TRP A 1 204 ? -1.95152  -2.74321  9.77705   1.000 26.99724 ? 556 TRP A CB  1 
ATOM   1512 C CG  . TRP A 1 204 ? -2.58840  -1.45921  9.36048   1.000 28.21758 ? 556 TRP A CG  1 
ATOM   1513 C CD1 . TRP A 1 204 ? -3.36146  -0.64512  10.12931  1.000 23.99743 ? 556 TRP A CD1 1 
ATOM   1514 C CD2 . TRP A 1 204 ? -2.48877  -0.82617  8.07689   1.000 25.08441 ? 556 TRP A CD2 1 
ATOM   1515 N NE1 . TRP A 1 204 ? -3.74531  0.46118   9.41171   1.000 26.21998 ? 556 TRP A NE1 1 
ATOM   1516 C CE2 . TRP A 1 204 ? -3.21537  0.38112   8.15222   1.000 25.50020 ? 556 TRP A CE2 1 
ATOM   1517 C CE3 . TRP A 1 204 ? -1.83037  -1.14913  6.88396   1.000 26.97870 ? 556 TRP A CE3 1 
ATOM   1518 C CZ2 . TRP A 1 204 ? -3.33454  1.25741   7.07098   1.000 26.83052 ? 556 TRP A CZ2 1 
ATOM   1519 C CZ3 . TRP A 1 204 ? -1.94782  -0.27342  5.79914   1.000 27.69504 ? 556 TRP A CZ3 1 
ATOM   1520 C CH2 . TRP A 1 204 ? -2.69350  0.91784   5.90676   1.000 31.61500 ? 556 TRP A CH2 1 
ATOM   1521 N N   . SER A 1 205 ? -2.09931  -2.56641  12.86652  1.000 24.29097 ? 557 SER A N   1 
ATOM   1522 C CA  . SER A 1 205 ? -2.64168  -1.97057  14.08678  1.000 28.23108 ? 557 SER A CA  1 
ATOM   1523 C C   . SER A 1 205 ? -1.52455  -1.50357  15.00109  1.000 25.08461 ? 557 SER A C   1 
ATOM   1524 O O   . SER A 1 205 ? -1.62699  -0.45819  15.65026  1.000 22.60888 ? 557 SER A O   1 
ATOM   1525 C CB  . SER A 1 205 ? -3.51181  -2.97941  14.84269  1.000 28.71404 ? 557 SER A CB  1 
ATOM   1526 O OG  . SER A 1 205 ? -4.43588  -3.60668  13.98298  1.000 36.27801 ? 557 SER A OG  1 
ATOM   1527 N N   . PHE A 1 206 ? -0.46111  -2.29097  15.08986  1.000 25.95923 ? 558 PHE A N   1 
ATOM   1528 C CA  . PHE A 1 206 ? 0.69021   -1.87479  15.88465  1.000 25.35030 ? 558 PHE A CA  1 
ATOM   1529 C C   . PHE A 1 206 ? 1.22389   -0.52113  15.43006  1.000 23.78913 ? 558 PHE A C   1 
ATOM   1530 O O   . PHE A 1 206 ? 1.68241   0.27959   16.25357  1.000 27.28240 ? 558 PHE A O   1 
ATOM   1531 C CB  . PHE A 1 206 ? 1.78212   -2.92621  15.80105  1.000 27.80045 ? 558 PHE A CB  1 
ATOM   1532 C CG  . PHE A 1 206 ? 2.97091   -2.61327  16.64519  1.000 24.66464 ? 558 PHE A CG  1 
ATOM   1533 C CD1 . PHE A 1 206 ? 2.91763   -2.76558  18.03290  1.000 28.21573 ? 558 PHE A CD1 1 
ATOM   1534 C CD2 . PHE A 1 206 ? 4.13651   -2.16472  16.06321  1.000 22.29177 ? 558 PHE A CD2 1 
ATOM   1535 C CE1 . PHE A 1 206 ? 4.03717   -2.49036  18.82189  1.000 34.52723 ? 558 PHE A CE1 1 
ATOM   1536 C CE2 . PHE A 1 206 ? 5.25692   -1.87941  16.84256  1.000 23.88320 ? 558 PHE A CE2 1 
ATOM   1537 C CZ  . PHE A 1 206 ? 5.20745   -2.04106  18.22483  1.000 32.96577 ? 558 PHE A CZ  1 
ATOM   1538 N N   . GLY A 1 207 ? 1.20068   -0.25267  14.12075  1.000 23.99395 ? 559 GLY A N   1 
ATOM   1539 C CA  . GLY A 1 207 ? 1.63606   1.05321   13.65164  1.000 20.70231 ? 559 GLY A CA  1 
ATOM   1540 C C   . GLY A 1 207 ? 0.78139   2.17919   14.20738  1.000 23.17970 ? 559 GLY A C   1 
ATOM   1541 O O   . GLY A 1 207 ? 1.29812   3.21316   14.63547  1.000 25.20832 ? 559 GLY A O   1 
ATOM   1542 N N   . VAL A 1 208 ? -0.54598  1.99464   14.18578  1.000 23.61915 ? 560 VAL A N   1 
ATOM   1543 C CA  . VAL A 1 208 ? -1.46263  2.95277   14.80308  1.000 27.34898 ? 560 VAL A CA  1 
ATOM   1544 C C   . VAL A 1 208 ? -1.20208  3.05362   16.29923  1.000 22.29310 ? 560 VAL A C   1 
ATOM   1545 O O   . VAL A 1 208 ? -1.18950  4.15260   16.87051  1.000 25.50859 ? 560 VAL A O   1 
ATOM   1546 C CB  . VAL A 1 208 ? -2.92616  2.54964   14.52501  1.000 25.15628 ? 560 VAL A CB  1 
ATOM   1547 C CG1 . VAL A 1 208 ? -3.88477  3.62527   15.02397  1.000 27.54375 ? 560 VAL A CG1 1 
ATOM   1548 C CG2 . VAL A 1 208 ? -3.13129  2.25645   13.05906  1.000 22.86581 ? 560 VAL A CG2 1 
ATOM   1549 N N   . LEU A 1 209 ? -1.02558  1.91248   16.96823  1.000 22.38922 ? 561 LEU A N   1 
ATOM   1550 C CA  . LEU A 1 209 ? -0.67256  1.94851   18.38999  1.000 29.07993 ? 561 LEU A CA  1 
ATOM   1551 C C   . LEU A 1 209 ? 0.59386   2.76622   18.62561  1.000 28.09168 ? 561 LEU A C   1 
ATOM   1552 O O   . LEU A 1 209 ? 0.64103   3.59484   19.54304  1.000 29.15738 ? 561 LEU A O   1 
ATOM   1553 C CB  . LEU A 1 209 ? -0.50842  0.52153   18.93253  1.000 29.73466 ? 561 LEU A CB  1 
ATOM   1554 C CG  . LEU A 1 209 ? -0.21085  0.32305   20.42838  1.000 28.65624 ? 561 LEU A CG  1 
ATOM   1555 C CD1 . LEU A 1 209 ? -0.60210  -1.09485  20.78572  1.000 29.67274 ? 561 LEU A CD1 1 
ATOM   1556 C CD2 . LEU A 1 209 ? 1.26237   0.55439   20.79385  1.000 26.30667 ? 561 LEU A CD2 1 
ATOM   1557 N N   . MET A 1 210 ? 1.62626   2.56143   17.79802  1.000 25.50998 ? 562 MET A N   1 
ATOM   1558 C CA  . MET A 1 210 ? 2.83228   3.38908   17.89515  1.000 26.50259 ? 562 MET A CA  1 
ATOM   1559 C C   . MET A 1 210 ? 2.50382   4.86804   17.74476  1.000 26.96819 ? 562 MET A C   1 
ATOM   1560 O O   . MET A 1 210 ? 2.99830   5.70665   18.50926  1.000 27.67558 ? 562 MET A O   1 
ATOM   1561 C CB  . MET A 1 210 ? 3.84570   2.97181   16.83277  1.000 26.87895 ? 562 MET A CB  1 
ATOM   1562 C CG  . MET A 1 210 ? 4.61571   1.70516   17.17198  1.000 31.08738 ? 562 MET A CG  1 
ATOM   1563 S SD  . MET A 1 210 ? 5.95541   1.44469   15.96881  1.000 40.31421 ? 562 MET A SD  1 
ATOM   1564 C CE  . MET A 1 210 ? 6.66852   3.08093   15.95075  1.000 44.80871 ? 562 MET A CE  1 
ATOM   1565 N N   . TRP A 1 211 ? 1.69012   5.20821   16.73561  1.000 28.28542 ? 563 TRP A N   1 
ATOM   1566 C CA  . TRP A 1 211 ? 1.27620   6.59496   16.54639  1.000 26.12939 ? 563 TRP A CA  1 
ATOM   1567 C C   . TRP A 1 211 ? 0.56832   7.12987   17.78522  1.000 29.87192 ? 563 TRP A C   1 
ATOM   1568 O O   . TRP A 1 211 ? 0.79565   8.27890   18.18876  1.000 29.29341 ? 563 TRP A O   1 
ATOM   1569 C CB  . TRP A 1 211 ? 0.36617   6.71911   15.31058  1.000 26.32709 ? 563 TRP A CB  1 
ATOM   1570 C CG  . TRP A 1 211 ? 0.04167   8.15429   14.96788  1.000 28.77014 ? 563 TRP A CG  1 
ATOM   1571 C CD1 . TRP A 1 211 ? 0.68161   8.95873   14.05082  1.000 31.11874 ? 563 TRP A CD1 1 
ATOM   1572 C CD2 . TRP A 1 211 ? -0.98255  8.95711   15.55425  1.000 27.63041 ? 563 TRP A CD2 1 
ATOM   1573 N NE1 . TRP A 1 211 ? 0.11241   10.21058  14.04438  1.000 27.22554 ? 563 TRP A NE1 1 
ATOM   1574 C CE2 . TRP A 1 211 ? -0.91352  10.23514  14.95131  1.000 32.46572 ? 563 TRP A CE2 1 
ATOM   1575 C CE3 . TRP A 1 211 ? -1.95315  8.72383   16.53557  1.000 29.40706 ? 563 TRP A CE3 1 
ATOM   1576 C CZ2 . TRP A 1 211 ? -1.78348  11.26479  15.29184  1.000 31.11414 ? 563 TRP A CZ2 1 
ATOM   1577 C CZ3 . TRP A 1 211 ? -2.80772  9.75263   16.88186  1.000 33.03419 ? 563 TRP A CZ3 1 
ATOM   1578 C CH2 . TRP A 1 211 ? -2.71643  11.00796  16.26528  1.000 30.87018 ? 563 TRP A CH2 1 
ATOM   1579 N N   . GLU A 1 212 ? -0.32614  6.33103   18.38354  1.000 25.19093 ? 564 GLU A N   1 
ATOM   1580 C CA  . GLU A 1 212 ? -0.98001  6.77428   19.61451  1.000 28.36976 ? 564 GLU A CA  1 
ATOM   1581 C C   . GLU A 1 212 ? 0.03719   6.98905   20.72844  1.000 33.02290 ? 564 GLU A C   1 
ATOM   1582 O O   . GLU A 1 212 ? -0.06131  7.95976   21.48620  1.000 34.06923 ? 564 GLU A O   1 
ATOM   1583 C CB  . GLU A 1 212 ? -2.01829  5.76618   20.09961  1.000 28.67845 ? 564 GLU A CB  1 
ATOM   1584 C CG  . GLU A 1 212 ? -3.14740  5.42033   19.14687  1.000 33.31961 ? 564 GLU A CG  1 
ATOM   1585 C CD  . GLU A 1 212 ? -4.02554  4.34552   19.74409  1.000 37.20212 ? 564 GLU A CD  1 
ATOM   1586 O OE1 . GLU A 1 212 ? -3.71925  3.13200   19.55660  1.000 27.02916 ? 564 GLU A OE1 1 
ATOM   1587 O OE2 . GLU A 1 212 ? -5.00100  4.71247   20.43889  1.000 34.20022 ? 564 GLU A OE2 1 
ATOM   1588 N N   . ALA A 1 213 ? 1.00453   6.08077   20.86272  1.000 30.37039 ? 565 ALA A N   1 
ATOM   1589 C CA  . ALA A 1 213 ? 1.96550   6.19526   21.95798  1.000 32.05431 ? 565 ALA A CA  1 
ATOM   1590 C C   . ALA A 1 213 ? 2.75529   7.49131   21.84683  1.000 35.45059 ? 565 ALA A C   1 
ATOM   1591 O O   . ALA A 1 213 ? 2.85703   8.25286   22.81657  1.000 32.78220 ? 565 ALA A O   1 
ATOM   1592 C CB  . ALA A 1 213 ? 2.90400   4.98810   21.98138  1.000 34.42013 ? 565 ALA A CB  1 
ATOM   1593 N N   . PHE A 1 214 ? 3.30622   7.77280   20.65831  1.000 33.36497 ? 566 PHE A N   1 
ATOM   1594 C CA  . PHE A 1 214 ? 4.09213   8.99076   20.48450  1.000 38.87223 ? 566 PHE A CA  1 
ATOM   1595 C C   . PHE A 1 214 ? 3.23786   10.24189  20.38765  1.000 33.46426 ? 566 PHE A C   1 
ATOM   1596 O O   . PHE A 1 214 ? 3.79123   11.34434  20.42135  1.000 38.50216 ? 566 PHE A O   1 
ATOM   1597 C CB  . PHE A 1 214 ? 4.99776   8.86787   19.25645  1.000 28.11229 ? 566 PHE A CB  1 
ATOM   1598 C CG  . PHE A 1 214 ? 6.12831   7.95042   19.48134  1.000 33.58000 ? 566 PHE A CG  1 
ATOM   1599 C CD1 . PHE A 1 214 ? 7.25842   8.38381   20.16607  1.000 35.97825 ? 566 PHE A CD1 1 
ATOM   1600 C CD2 . PHE A 1 214 ? 6.04521   6.62759   19.08900  1.000 27.89111 ? 566 PHE A CD2 1 
ATOM   1601 C CE1 . PHE A 1 214 ? 8.29490   7.51933   20.41786  1.000 31.59002 ? 566 PHE A CE1 1 
ATOM   1602 C CE2 . PHE A 1 214 ? 7.09159   5.74924   19.33367  1.000 36.35749 ? 566 PHE A CE2 1 
ATOM   1603 C CZ  . PHE A 1 214 ? 8.21721   6.19391   20.00059  1.000 31.36654 ? 566 PHE A CZ  1 
ATOM   1604 N N   . SER A 1 215 ? 1.91256   10.10837  20.28474  1.000 34.79038 ? 567 SER A N   1 
ATOM   1605 C CA  . SER A 1 215 ? 1.01204   11.24878  20.37653  1.000 28.72670 ? 567 SER A CA  1 
ATOM   1606 C C   . SER A 1 215 ? 0.45430   11.41215  21.78639  1.000 39.25338 ? 567 SER A C   1 
ATOM   1607 O O   . SER A 1 215 ? -0.54977  12.10944  21.97892  1.000 35.24728 ? 567 SER A O   1 
ATOM   1608 C CB  . SER A 1 215 ? -0.12375  11.11819  19.36058  1.000 30.60541 ? 567 SER A CB  1 
ATOM   1609 O OG  . SER A 1 215 ? 0.38138   11.09572  18.02359  1.000 31.54246 ? 567 SER A OG  1 
ATOM   1610 N N   . TYR A 1 216 ? 1.08496   10.75885  22.76582  1.000 34.80407 ? 568 TYR A N   1 
ATOM   1611 C CA  . TYR A 1 216 ? 0.69887   10.83527  24.17582  1.000 41.18854 ? 568 TYR A CA  1 
ATOM   1612 C C   . TYR A 1 216 ? -0.78608  10.53970  24.34735  1.000 31.46022 ? 568 TYR A C   1 
ATOM   1613 O O   . TYR A 1 216 ? -1.49676  11.17694  25.12194  1.000 35.24623 ? 568 TYR A O   1 
ATOM   1614 C CB  . TYR A 1 216 ? 1.10731   12.17832  24.78341  1.000 39.66489 ? 568 TYR A CB  1 
ATOM   1615 C CG  . TYR A 1 216 ? 2.61989   12.25659  24.89862  1.000 40.81806 ? 568 TYR A CG  1 
ATOM   1616 C CD1 . TYR A 1 216 ? 3.27578   11.78026  26.03027  1.000 43.44189 ? 568 TYR A CD1 1 
ATOM   1617 C CD2 . TYR A 1 216 ? 3.39033   12.75163  23.85322  1.000 44.26215 ? 568 TYR A CD2 1 
ATOM   1618 C CE1 . TYR A 1 216 ? 4.66158   11.81759  26.12830  1.000 42.38981 ? 568 TYR A CE1 1 
ATOM   1619 C CE2 . TYR A 1 216 ? 4.77063   12.79206  23.93856  1.000 37.13910 ? 568 TYR A CE2 1 
ATOM   1620 C CZ  . TYR A 1 216 ? 5.39612   12.32238  25.07891  1.000 39.29554 ? 568 TYR A CZ  1 
ATOM   1621 O OH  . TYR A 1 216 ? 6.75982   12.36356  25.17069  1.000 39.71988 ? 568 TYR A OH  1 
ATOM   1622 N N   . GLY A 1 217 ? -1.25324  9.55202   23.59723  1.000 34.36813 ? 569 GLY A N   1 
ATOM   1623 C CA  . GLY A 1 217 ? -2.58054  9.03076   23.78707  1.000 30.41621 ? 569 GLY A CA  1 
ATOM   1624 C C   . GLY A 1 217 ? -3.68119  9.74551   23.05795  1.000 31.35258 ? 569 GLY A C   1 
ATOM   1625 O O   . GLY A 1 217 ? -4.84016  9.59745   23.44867  1.000 33.49434 ? 569 GLY A O   1 
ATOM   1626 N N   . GLN A 1 218 ? -3.37274  10.51744  22.01565  1.000 36.23516 ? 570 GLN A N   1 
ATOM   1627 C CA  . GLN A 1 218 ? -4.44326  11.09308  21.21251  1.000 29.44755 ? 570 GLN A CA  1 
ATOM   1628 C C   . GLN A 1 218 ? -5.11582  10.00981  20.37304  1.000 33.71184 ? 570 GLN A C   1 
ATOM   1629 O O   . GLN A 1 218 ? -4.52946  8.96671   20.07583  1.000 33.48249 ? 570 GLN A O   1 
ATOM   1630 C CB  . GLN A 1 218 ? -3.91017  12.20372  20.30290  1.000 35.75158 ? 570 GLN A CB  1 
ATOM   1631 C CG  . GLN A 1 218 ? -4.26195  13.61957  20.78648  1.000 49.85892 ? 570 GLN A CG  1 
ATOM   1632 C CD  . GLN A 1 218 ? -3.27277  14.17099  21.80778  1.000 66.10253 ? 570 GLN A CD  1 
ATOM   1633 O OE1 . GLN A 1 218 ? -2.09493  14.40343  21.49147  1.000 62.44918 ? 570 GLN A OE1 1 
ATOM   1634 N NE2 . GLN A 1 218 ? -3.74446  14.38502  23.04100  1.000 54.33411 ? 570 GLN A NE2 1 
ATOM   1635 N N   . LYS A 1 219 ? -6.36776  10.26089  20.00110  1.000 34.01251 ? 571 LYS A N   1 
ATOM   1636 C CA  . LYS A 1 219 ? -7.04661  9.29024   19.15688  1.000 32.10919 ? 571 LYS A CA  1 
ATOM   1637 C C   . LYS A 1 219 ? -6.55875  9.40749   17.71487  1.000 29.38381 ? 571 LYS A C   1 
ATOM   1638 O O   . LYS A 1 219 ? -6.33550  10.51160  17.21243  1.000 28.96440 ? 571 LYS A O   1 
ATOM   1639 C CB  . LYS A 1 219 ? -8.57282  9.47556   19.19018  1.000 27.60312 ? 571 LYS A CB  1 
ATOM   1640 C CG  . LYS A 1 219 ? -9.22667  9.08359   20.51245  1.000 37.23974 ? 571 LYS A CG  1 
ATOM   1641 C CD  . LYS A 1 219 ? -10.63153 8.50409   20.29329  1.000 54.42659 ? 571 LYS A CD  1 
ATOM   1642 C CE  . LYS A 1 219 ? -10.60543 7.08414   19.67738  1.000 54.88054 ? 571 LYS A CE  1 
ATOM   1643 N NZ  . LYS A 1 219 ? -10.91913 7.01682   18.19544  1.000 41.34586 ? 571 LYS A NZ  1 
ATOM   1644 N N   . PRO A 1 220 ? -6.42954  8.28904   17.02028  1.000 26.98266 ? 572 PRO A N   1 
ATOM   1645 C CA  . PRO A 1 220 ? -6.01956  8.33699   15.62154  1.000 28.69665 ? 572 PRO A CA  1 
ATOM   1646 C C   . PRO A 1 220 ? -7.15739  8.81786   14.74398  1.000 28.81050 ? 572 PRO A C   1 
ATOM   1647 O O   . PRO A 1 220 ? -8.32981  8.63656   15.07084  1.000 28.73314 ? 572 PRO A O   1 
ATOM   1648 C CB  . PRO A 1 220 ? -5.66388  6.87653   15.31011  1.000 32.56145 ? 572 PRO A CB  1 
ATOM   1649 C CG  . PRO A 1 220 ? -6.55188  6.09185   16.21094  1.000 28.15727 ? 572 PRO A CG  1 
ATOM   1650 C CD  . PRO A 1 220 ? -6.70495  6.91608   17.47753  1.000 28.04137 ? 572 PRO A CD  1 
ATOM   1651 N N   . TYR A 1 221 ? -6.78373  9.42639   13.61449  1.000 27.52595 ? 573 TYR A N   1 
ATOM   1652 C CA  . TYR A 1 221 ? -7.71914  9.92100   12.60373  1.000 29.42651 ? 573 TYR A CA  1 
ATOM   1653 C C   . TYR A 1 221 ? -8.81238  10.77139  13.24598  1.000 37.37480 ? 573 TYR A C   1 
ATOM   1654 O O   . TYR A 1 221 ? -10.01416 10.57747  13.01023  1.000 33.04554 ? 573 TYR A O   1 
ATOM   1655 C CB  . TYR A 1 221 ? -8.32695  8.76978   11.79997  1.000 29.10311 ? 573 TYR A CB  1 
ATOM   1656 C CG  . TYR A 1 221 ? -7.30251  7.83022   11.18891  1.000 29.13686 ? 573 TYR A CG  1 
ATOM   1657 C CD1 . TYR A 1 221 ? -6.64591  8.15747   10.01267  1.000 26.30164 ? 573 TYR A CD1 1 
ATOM   1658 C CD2 . TYR A 1 221 ? -7.02006  6.60209   11.78174  1.000 32.30637 ? 573 TYR A CD2 1 
ATOM   1659 C CE1 . TYR A 1 221 ? -5.71668  7.29371   9.44283   1.000 28.89950 ? 573 TYR A CE1 1 
ATOM   1660 C CE2 . TYR A 1 221 ? -6.08995  5.74110   11.22810  1.000 25.97780 ? 573 TYR A CE2 1 
ATOM   1661 C CZ  . TYR A 1 221 ? -5.45362  6.08690   10.05507  1.000 23.82193 ? 573 TYR A CZ  1 
ATOM   1662 O OH  . TYR A 1 221 ? -4.52427  5.21993   9.48972   1.000 26.37219 ? 573 TYR A OH  1 
ATOM   1663 N N   . ARG A 1 222 ? -8.37514  11.71926  14.07501  1.000 29.68922 ? 574 ARG A N   1 
ATOM   1664 C CA  . ARG A 1 222 ? -9.30210  12.54199  14.84586  1.000 37.81824 ? 574 ARG A CA  1 
ATOM   1665 C C   . ARG A 1 222 ? -10.32611 13.20879  13.93247  1.000 36.77076 ? 574 ARG A C   1 
ATOM   1666 O O   . ARG A 1 222 ? -9.97576  13.78596  12.89947  1.000 33.39215 ? 574 ARG A O   1 
ATOM   1667 C CB  . ARG A 1 222 ? -8.52304  13.59850  15.64078  1.000 36.28653 ? 574 ARG A CB  1 
ATOM   1668 C CG  . ARG A 1 222 ? -9.40965  14.64549  16.30469  1.000 48.11958 ? 574 ARG A CG  1 
ATOM   1669 C CD  . ARG A 1 222 ? -8.62694  15.47359  17.31155  1.000 47.81084 ? 574 ARG A CD  1 
ATOM   1670 N NE  . ARG A 1 222 ? -7.72145  16.41578  16.66963  1.000 44.81784 ? 574 ARG A NE  1 
ATOM   1671 C CZ  . ARG A 1 222 ? -6.67007  16.95374  17.26959  1.000 43.13591 ? 574 ARG A CZ  1 
ATOM   1672 N NH1 . ARG A 1 222 ? -6.34435  16.63454  18.51663  1.000 38.36040 ? 574 ARG A NH1 1 
ATOM   1673 N NH2 . ARG A 1 222 ? -5.92586  17.83085  16.60567  1.000 41.33884 ? 574 ARG A NH2 1 
ATOM   1674 N N   . GLY A 1 223 ? -11.59933 13.08315  14.30131  1.000 37.61754 ? 575 GLY A N   1 
ATOM   1675 C CA  . GLY A 1 223 ? -12.68175 13.74791  13.60923  1.000 34.92575 ? 575 GLY A CA  1 
ATOM   1676 C C   . GLY A 1 223 ? -13.13319 13.12327  12.30810  1.000 49.20048 ? 575 GLY A C   1 
ATOM   1677 O O   . GLY A 1 223 ? -13.93388 13.74505  11.59627  1.000 40.74025 ? 575 GLY A O   1 
ATOM   1678 N N   . MET A 1 224 ? -12.65551 11.92430  11.96320  1.000 32.46884 ? 576 MET A N   1 
ATOM   1679 C CA  . MET A 1 224 ? -12.99968 11.28596  10.69765  1.000 33.61371 ? 576 MET A CA  1 
ATOM   1680 C C   . MET A 1 224 ? -13.92474 10.10181  10.92628  1.000 34.33128 ? 576 MET A C   1 
ATOM   1681 O O   . MET A 1 224 ? -13.77570 9.36715   11.90666  1.000 34.66667 ? 576 MET A O   1 
ATOM   1682 C CB  . MET A 1 224 ? -11.75217 10.80168  9.94541   1.000 29.51588 ? 576 MET A CB  1 
ATOM   1683 C CG  . MET A 1 224 ? -10.74775 11.87378  9.65771   1.000 29.87003 ? 576 MET A CG  1 
ATOM   1684 S SD  . MET A 1 224 ? -9.38696  11.09262  8.81431   1.000 40.77618 ? 576 MET A SD  1 
ATOM   1685 C CE  . MET A 1 224 ? -8.07186  12.10524  9.21282   1.000 41.31837 ? 576 MET A CE  1 
ATOM   1686 N N   . LYS A 1 225 ? -14.87087 9.92107   10.00562  1.000 35.42207 ? 577 LYS A N   1 
ATOM   1687 C CA  . LYS A 1 225 ? -15.70789 8.73150   9.97318   1.000 41.19407 ? 577 LYS A CA  1 
ATOM   1688 C C   . LYS A 1 225 ? -14.92090 7.54898   9.40870   1.000 37.80506 ? 577 LYS A C   1 
ATOM   1689 O O   . LYS A 1 225 ? -13.88645 7.71682   8.75759   1.000 35.53013 ? 577 LYS A O   1 
ATOM   1690 C CB  . LYS A 1 225 ? -16.96215 8.97201   9.12387   1.000 49.01258 ? 577 LYS A CB  1 
ATOM   1691 C CG  . LYS A 1 225 ? -17.62393 10.33602  9.37127   1.000 52.31175 ? 577 LYS A CG  1 
ATOM   1692 C CD  . LYS A 1 225 ? -19.05495 10.39837  8.83887   1.000 61.68420 ? 577 LYS A CD  1 
ATOM   1693 C CE  . LYS A 1 225 ? -19.11178 10.88056  7.39814   1.000 60.72809 ? 577 LYS A CE  1 
ATOM   1694 N NZ  . LYS A 1 225 ? -20.50615 11.29807  7.04332   1.000 60.11879 ? 577 LYS A NZ  1 
ATOM   1695 N N   . GLY A 1 226 ? -15.43401 6.34261   9.66373   1.000 40.55668 ? 578 GLY A N   1 
ATOM   1696 C CA  . GLY A 1 226 ? -14.77333 5.13646   9.17669   1.000 41.86187 ? 578 GLY A CA  1 
ATOM   1697 C C   . GLY A 1 226 ? -14.56867 5.13547   7.67356   1.000 44.75003 ? 578 GLY A C   1 
ATOM   1698 O O   . GLY A 1 226 ? -13.46374 4.88554   7.18274   1.000 35.24633 ? 578 GLY A O   1 
ATOM   1699 N N   . SER A 1 227 ? -15.63057 5.43341   6.91709   1.000 33.17612 ? 579 SER A N   1 
ATOM   1700 C CA  . SER A 1 227 ? -15.51204 5.47292   5.46056   1.000 36.04989 ? 579 SER A CA  1 
ATOM   1701 C C   . SER A 1 227 ? -14.48214 6.49392   5.00003   1.000 39.97741 ? 579 SER A C   1 
ATOM   1702 O O   . SER A 1 227 ? -13.83562 6.29930   3.96257   1.000 38.47894 ? 579 SER A O   1 
ATOM   1703 C CB  . SER A 1 227 ? -16.86597 5.79683   4.83006   1.000 50.04883 ? 579 SER A CB  1 
ATOM   1704 O OG  . SER A 1 227 ? -17.25349 7.12253   5.15204   1.000 42.45399 ? 579 SER A OG  1 
ATOM   1705 N N   . GLU A 1 228 ? -14.31585 7.58458   5.74833   1.000 34.57845 ? 580 GLU A N   1 
ATOM   1706 C CA  . GLU A 1 228 ? -13.34174 8.60218   5.36427   1.000 36.56502 ? 580 GLU A CA  1 
ATOM   1707 C C   . GLU A 1 228 ? -11.90796 8.13342   5.61718   1.000 34.28775 ? 580 GLU A C   1 
ATOM   1708 O O   . GLU A 1 228 ? -11.01079 8.40938   4.81013   1.000 32.62203 ? 580 GLU A O   1 
ATOM   1709 C CB  . GLU A 1 228 ? -13.63385 9.90337   6.11674   1.000 35.83660 ? 580 GLU A CB  1 
ATOM   1710 C CG  . GLU A 1 228 ? -14.97203 10.51049  5.75126   1.000 35.55135 ? 580 GLU A CG  1 
ATOM   1711 C CD  . GLU A 1 228 ? -15.32879 11.71833  6.59834   1.000 50.67211 ? 580 GLU A CD  1 
ATOM   1712 O OE1 . GLU A 1 228 ? -15.03978 11.71732  7.81513   1.000 42.99820 ? 580 GLU A OE1 1 
ATOM   1713 O OE2 . GLU A 1 228 ? -15.90639 12.67540  6.04212   1.000 54.33844 ? 580 GLU A OE2 1 
ATOM   1714 N N   . VAL A 1 229 ? -11.67231 7.44594   6.73860   1.000 32.94059 ? 581 VAL A N   1 
ATOM   1715 C CA  . VAL A 1 229 ? -10.37742 6.80156   6.97923   1.000 32.49748 ? 581 VAL A CA  1 
ATOM   1716 C C   . VAL A 1 229 ? -10.04447 5.84291   5.84254   1.000 32.51000 ? 581 VAL A C   1 
ATOM   1717 O O   . VAL A 1 229 ? -8.93919  5.86761   5.27680   1.000 27.91951 ? 581 VAL A O   1 
ATOM   1718 C CB  . VAL A 1 229 ? -10.39317 6.07824   8.34270   1.000 33.45136 ? 581 VAL A CB  1 
ATOM   1719 C CG1 . VAL A 1 229 ? -9.07682  5.34140   8.59035   1.000 31.43551 ? 581 VAL A CG1 1 
ATOM   1720 C CG2 . VAL A 1 229 ? -10.65806 7.07682   9.46013   1.000 34.04267 ? 581 VAL A CG2 1 
ATOM   1721 N N   . THR A 1 230 ? -11.00729 4.99135   5.47775   1.000 33.54484 ? 582 THR A N   1 
ATOM   1722 C CA  . THR A 1 230 ? -10.76189 3.98862   4.44585   1.000 39.24673 ? 582 THR A CA  1 
ATOM   1723 C C   . THR A 1 230 ? -10.35662 4.64530   3.12916   1.000 40.17746 ? 582 THR A C   1 
ATOM   1724 O O   . THR A 1 230 ? -9.35370  4.25768   2.51101   1.000 38.28562 ? 582 THR A O   1 
ATOM   1725 C CB  . THR A 1 230 ? -12.00381 3.10271   4.26851   1.000 41.16422 ? 582 THR A CB  1 
ATOM   1726 O OG1 . THR A 1 230 ? -12.22682 2.35141   5.47047   1.000 34.70135 ? 582 THR A OG1 1 
ATOM   1727 C CG2 . THR A 1 230 ? -11.82417 2.14171   3.09985   1.000 41.37494 ? 582 THR A CG2 1 
ATOM   1728 N N   . ALA A 1 231 ? -11.09521 5.67531   2.70629   1.000 38.39208 ? 583 ALA A N   1 
ATOM   1729 C CA  . ALA A 1 231 ? -10.76370 6.34772   1.45130   1.000 35.92565 ? 583 ALA A CA  1 
ATOM   1730 C C   . ALA A 1 231 ? -9.38911  7.00805   1.52322   1.000 39.42527 ? 583 ALA A C   1 
ATOM   1731 O O   . ALA A 1 231 ? -8.62214  6.96834   0.55289   1.000 40.23170 ? 583 ALA A O   1 
ATOM   1732 C CB  . ALA A 1 231 ? -11.83219 7.38147   1.11277   1.000 39.67839 ? 583 ALA A CB  1 
ATOM   1733 N N   . MET A 1 232 ? -9.07240  7.63666   2.66034   1.000 36.04006 ? 584 MET A N   1 
ATOM   1734 C CA  . MET A 1 232 ? -7.76511  8.26645   2.83875   1.000 33.91068 ? 584 MET A CA  1 
ATOM   1735 C C   . MET A 1 232 ? -6.64445  7.26664   2.60085   1.000 32.18921 ? 584 MET A C   1 
ATOM   1736 O O   . MET A 1 232 ? -5.67617  7.55262   1.88267   1.000 35.21371 ? 584 MET A O   1 
ATOM   1737 C CB  . MET A 1 232 ? -7.66619  8.86047   4.24359   1.000 36.99092 ? 584 MET A CB  1 
ATOM   1738 C CG  . MET A 1 232 ? -6.34355  9.57201   4.55792   1.000 37.68603 ? 584 MET A CG  1 
ATOM   1739 S SD  . MET A 1 232 ? -6.19881  9.84634   6.33004   1.000 37.35377 ? 584 MET A SD  1 
ATOM   1740 C CE  . MET A 1 232 ? -4.49075  10.34410  6.51430   1.000 35.16018 ? 584 MET A CE  1 
ATOM   1741 N N   . LEU A 1 233 ? -6.75835  6.08383   3.20919   1.000 29.80743 ? 585 LEU A N   1 
ATOM   1742 C CA  . LEU A 1 233 ? -5.71607  5.07208   3.06869   1.000 34.74950 ? 585 LEU A CA  1 
ATOM   1743 C C   . LEU A 1 233 ? -5.65721  4.53962   1.63964   1.000 31.61408 ? 585 LEU A C   1 
ATOM   1744 O O   . LEU A 1 233 ? -4.56564  4.29913   1.09823   1.000 29.44323 ? 585 LEU A O   1 
ATOM   1745 C CB  . LEU A 1 233 ? -5.95730  3.93968   4.07483   1.000 32.31067 ? 585 LEU A CB  1 
ATOM   1746 C CG  . LEU A 1 233 ? -5.96912  4.35140   5.55304   1.000 33.09366 ? 585 LEU A CG  1 
ATOM   1747 C CD1 . LEU A 1 233 ? -6.48008  3.21343   6.47616   1.000 26.46137 ? 585 LEU A CD1 1 
ATOM   1748 C CD2 . LEU A 1 233 ? -4.57027  4.86335   5.99689   1.000 28.76587 ? 585 LEU A CD2 1 
ATOM   1749 N N   . GLU A 1 234 ? -6.81833  4.35274   1.00711   1.000 31.21073 ? 586 GLU A N   1 
ATOM   1750 C CA  . GLU A 1 234 ? -6.82753  3.87714   -0.37473  1.000 34.09418 ? 586 GLU A CA  1 
ATOM   1751 C C   . GLU A 1 234 ? -6.16689  4.88256   -1.31552  1.000 34.75120 ? 586 GLU A C   1 
ATOM   1752 O O   . GLU A 1 234 ? -5.57465  4.47958   -2.32404  1.000 36.11177 ? 586 GLU A O   1 
ATOM   1753 C CB  . GLU A 1 234 ? -8.26017  3.56684   -0.83561  1.000 38.35441 ? 586 GLU A CB  1 
ATOM   1754 C CG  . GLU A 1 234 ? -9.01892  2.53884   0.02044   1.000 43.36647 ? 586 GLU A CG  1 
ATOM   1755 C CD  . GLU A 1 234 ? -8.57117  1.09887   -0.18952  1.000 50.43625 ? 586 GLU A CD  1 
ATOM   1756 O OE1 . GLU A 1 234 ? -7.86039  0.82355   -1.18125  1.000 56.74296 ? 586 GLU A OE1 1 
ATOM   1757 O OE2 . GLU A 1 234 ? -8.93889  0.23531   0.64316   1.000 55.72896 ? 586 GLU A OE2 1 
ATOM   1758 N N   . LYS A 1 235 ? -6.24808  6.18712   -1.00105  1.000 32.19210 ? 587 LYS A N   1 
ATOM   1759 C CA  . LYS A 1 235 ? -5.55119  7.21750   -1.76698  1.000 27.77344 ? 587 LYS A CA  1 
ATOM   1760 C C   . LYS A 1 235 ? -4.04258  7.18334   -1.55267  1.000 34.91176 ? 587 LYS A C   1 
ATOM   1761 O O   . LYS A 1 235 ? -3.31588  7.87472   -2.26954  1.000 34.18020 ? 587 LYS A O   1 
ATOM   1762 C CB  . LYS A 1 235 ? -6.05641  8.62424   -1.40252  1.000 38.87616 ? 587 LYS A CB  1 
ATOM   1763 C CG  . LYS A 1 235 ? -7.46156  9.00545   -1.89889  1.000 52.41332 ? 587 LYS A CG  1 
ATOM   1764 C CD  . LYS A 1 235 ? -7.83034  10.43928  -1.45213  1.000 50.47122 ? 587 LYS A CD  1 
ATOM   1765 C CE  . LYS A 1 235 ? -9.34265  10.61634  -1.21878  1.000 61.90402 ? 587 LYS A CE  1 
ATOM   1766 N NZ  . LYS A 1 235 ? -9.70082  10.84561  0.22603   1.000 52.40665 ? 587 LYS A NZ  1 
ATOM   1767 N N   . GLY A 1 236 ? -3.55480  6.41471   -0.58576  1.000 33.19591 ? 588 GLY A N   1 
ATOM   1768 C CA  . GLY A 1 236 ? -2.14208  6.42436   -0.26701  1.000 30.51486 ? 588 GLY A CA  1 
ATOM   1769 C C   . GLY A 1 236 ? -1.71797  7.41945   0.78882   1.000 34.71306 ? 588 GLY A C   1 
ATOM   1770 O O   . GLY A 1 236 ? -0.50920  7.56255   1.02638   1.000 30.70545 ? 588 GLY A O   1 
ATOM   1771 N N   . GLU A 1 237 ? -2.66088  8.11170   1.43362   1.000 28.35838 ? 589 GLU A N   1 
ATOM   1772 C CA  . GLU A 1 237 ? -2.30031  9.06465   2.47153   1.000 27.47764 ? 589 GLU A CA  1 
ATOM   1773 C C   . GLU A 1 237 ? -2.23724  8.34915   3.82037   1.000 29.92704 ? 589 GLU A C   1 
ATOM   1774 O O   . GLU A 1 237 ? -2.80429  7.26977   4.00346   1.000 28.70057 ? 589 GLU A O   1 
ATOM   1775 C CB  . GLU A 1 237 ? -3.29100  10.22989  2.53186   1.000 32.82754 ? 589 GLU A CB  1 
ATOM   1776 C CG  . GLU A 1 237 ? -3.33858  11.10972  1.28324   1.000 38.12834 ? 589 GLU A CG  1 
ATOM   1777 C CD  . GLU A 1 237 ? -4.56283  12.03687  1.25725   1.000 53.01878 ? 589 GLU A CD  1 
ATOM   1778 O OE1 . GLU A 1 237 ? -5.24329  12.18285  2.29985   1.000 50.33907 ? 589 GLU A OE1 1 
ATOM   1779 O OE2 . GLU A 1 237 ? -4.84972  12.62094  0.18922   1.000 53.54511 ? 589 GLU A OE2 1 
ATOM   1780 N N   . ARG A 1 238 ? -1.49837  8.95044   4.75159   1.000 27.45734 ? 590 ARG A N   1 
ATOM   1781 C CA  . ARG A 1 238 ? -1.24662  8.38071   6.06883   1.000 31.02454 ? 590 ARG A CA  1 
ATOM   1782 C C   . ARG A 1 238 ? -1.22553  9.50889   7.09076   1.000 31.37403 ? 590 ARG A C   1 
ATOM   1783 O O   . ARG A 1 238 ? -0.99754  10.67242  6.74857   1.000 28.04327 ? 590 ARG A O   1 
ATOM   1784 C CB  . ARG A 1 238 ? 0.08485   7.61816   6.10580   1.000 26.75575 ? 590 ARG A CB  1 
ATOM   1785 C CG  . ARG A 1 238 ? 0.18803   6.46895   5.11814   1.000 26.72452 ? 590 ARG A CG  1 
ATOM   1786 C CD  . ARG A 1 238 ? -0.75619  5.33392   5.48227   1.000 30.08741 ? 590 ARG A CD  1 
ATOM   1787 N NE  . ARG A 1 238 ? -0.53627  4.14536   4.66365   1.000 27.24691 ? 590 ARG A NE  1 
ATOM   1788 C CZ  . ARG A 1 238 ? -1.20450  3.87366   3.55062   1.000 28.87166 ? 590 ARG A CZ  1 
ATOM   1789 N NH1 . ARG A 1 238 ? -2.09089  4.72541   3.04634   1.000 28.79704 ? 590 ARG A NH1 1 
ATOM   1790 N NH2 . ARG A 1 238 ? -0.98430  2.71980   2.92777   1.000 25.40161 ? 590 ARG A NH2 1 
ATOM   1791 N N   . MET A 1 239 ? -1.48224  9.15455   8.35415   1.000 28.12048 ? 591 MET A N   1 
ATOM   1792 C CA  . MET A 1 239 ? -1.38395  10.12975  9.42730   1.000 28.59328 ? 591 MET A CA  1 
ATOM   1793 C C   . MET A 1 239 ? 0.01663   10.72388  9.46288   1.000 31.97739 ? 591 MET A C   1 
ATOM   1794 O O   . MET A 1 239 ? 1.00104   10.05931  9.13133   1.000 25.83625 ? 591 MET A O   1 
ATOM   1795 C CB  . MET A 1 239 ? -1.71568  9.47667   10.77159  1.000 28.84648 ? 591 MET A CB  1 
ATOM   1796 C CG  . MET A 1 239 ? -3.21160  9.20988   10.99161  1.000 27.81304 ? 591 MET A CG  1 
ATOM   1797 S SD  . MET A 1 239 ? -3.45652  8.71251   12.71338  1.000 34.40011 ? 591 MET A SD  1 
ATOM   1798 C CE  . MET A 1 239 ? -2.81727  7.03639   12.69465  1.000 29.94516 ? 591 MET A CE  1 
ATOM   1799 N N   . GLY A 1 240 ? 0.09567   12.00659  9.82991   1.000 29.77079 ? 592 GLY A N   1 
ATOM   1800 C CA  . GLY A 1 240 ? 1.36705   12.68631  9.91843   1.000 34.30733 ? 592 GLY A CA  1 
ATOM   1801 C C   . GLY A 1 240 ? 2.15767   12.30876  11.15263  1.000 29.91308 ? 592 GLY A C   1 
ATOM   1802 O O   . GLY A 1 240 ? 1.71614   11.56414  12.02659  1.000 34.70038 ? 592 GLY A O   1 
ATOM   1803 N N   . CYS A 1 241 ? 3.36823   12.83247  11.20698  1.000 31.24132 ? 593 CYS A N   1 
ATOM   1804 C CA  . CYS A 1 241 ? 4.32309   12.48131  12.24904  1.000 27.45375 ? 593 CYS A CA  1 
ATOM   1805 C C   . CYS A 1 241 ? 3.97782   13.20075  13.55170  1.000 37.21105 ? 593 CYS A C   1 
ATOM   1806 O O   . CYS A 1 241 ? 3.82697   14.42823  13.55061  1.000 40.56594 ? 593 CYS A O   1 
ATOM   1807 C CB  . CYS A 1 241 ? 5.73282   12.86067  11.78682  1.000 35.17604 ? 593 CYS A CB  1 
ATOM   1808 S SG  . CYS A 1 241 ? 7.02274   12.47610  12.96755  1.000 38.53396 ? 593 CYS A SG  1 
ATOM   1809 N N   . PRO A 1 242 ? 3.84868   12.48166  14.67342  1.000 32.67380 ? 594 PRO A N   1 
ATOM   1810 C CA  . PRO A 1 242 ? 3.53000   13.15221  15.94525  1.000 36.65581 ? 594 PRO A CA  1 
ATOM   1811 C C   . PRO A 1 242 ? 4.62178   14.13042  16.36000  1.000 38.18848 ? 594 PRO A C   1 
ATOM   1812 O O   . PRO A 1 242 ? 5.80739   13.92860  16.08601  1.000 37.93483 ? 594 PRO A O   1 
ATOM   1813 C CB  . PRO A 1 242 ? 3.41968   11.99034  16.95045  1.000 33.53436 ? 594 PRO A CB  1 
ATOM   1814 C CG  . PRO A 1 242 ? 3.17433   10.75884  16.11012  1.000 33.17974 ? 594 PRO A CG  1 
ATOM   1815 C CD  . PRO A 1 242 ? 3.90042   11.01328  14.80596  1.000 33.70017 ? 594 PRO A CD  1 
ATOM   1816 N N   . ALA A 1 243 ? 4.20265   15.19257  17.04449  1.000 36.95421 ? 595 ALA A N   1 
ATOM   1817 C CA  . ALA A 1 243 ? 5.13799   16.20048  17.52537  1.000 48.27609 ? 595 ALA A CA  1 
ATOM   1818 C C   . ALA A 1 243 ? 6.19491   15.56668  18.41833  1.000 41.92001 ? 595 ALA A C   1 
ATOM   1819 O O   . ALA A 1 243 ? 5.87717   14.84149  19.36792  1.000 41.30184 ? 595 ALA A O   1 
ATOM   1820 C CB  . ALA A 1 243 ? 4.38769   17.29785  18.28288  1.000 50.51324 ? 595 ALA A CB  1 
ATOM   1821 N N   . GLY A 1 244 ? 7.45858   15.82856  18.09657  1.000 36.78767 ? 596 GLY A N   1 
ATOM   1822 C CA  . GLY A 1 244 ? 8.56400   15.27108  18.84347  1.000 37.09413 ? 596 GLY A CA  1 
ATOM   1823 C C   . GLY A 1 244 ? 8.83434   13.80306  18.60936  1.000 39.20143 ? 596 GLY A C   1 
ATOM   1824 O O   . GLY A 1 244 ? 9.72741   13.25000  19.25416  1.000 47.62457 ? 596 GLY A O   1 
ATOM   1825 N N   . CYS A 1 245 ? 8.10540   13.14973  17.71418  1.000 41.13695 ? 597 CYS A N   1 
ATOM   1826 C CA  . CYS A 1 245 ? 8.32616   11.72568  17.48620  1.000 30.22493 ? 597 CYS A CA  1 
ATOM   1827 C C   . CYS A 1 245 ? 9.65621   11.50214  16.77430  1.000 44.34644 ? 597 CYS A C   1 
ATOM   1828 O O   . CYS A 1 245 ? 9.95317   12.19483  15.79103  1.000 44.67454 ? 597 CYS A O   1 
ATOM   1829 C CB  . CYS A 1 245 ? 7.17888   11.13068  16.67081  1.000 33.08509 ? 597 CYS A CB  1 
ATOM   1830 S SG  . CYS A 1 245 ? 7.43626   9.41252   16.26644  1.000 37.57470 ? 597 CYS A SG  1 
ATOM   1831 N N   . PRO A 1 246 ? 10.48658  10.56527  17.24044  1.000 41.80756 ? 598 PRO A N   1 
ATOM   1832 C CA  . PRO A 1 246 ? 11.74296  10.27034  16.54003  1.000 41.93330 ? 598 PRO A CA  1 
ATOM   1833 C C   . PRO A 1 246 ? 11.46870  9.87580   15.10019  1.000 42.75119 ? 598 PRO A C   1 
ATOM   1834 O O   . PRO A 1 246 ? 10.54333  9.11380   14.81691  1.000 34.46272 ? 598 PRO A O   1 
ATOM   1835 C CB  . PRO A 1 246 ? 12.32613  9.10004   17.33717  1.000 40.08251 ? 598 PRO A CB  1 
ATOM   1836 C CG  . PRO A 1 246 ? 11.69632  9.22809   18.69714  1.000 37.22473 ? 598 PRO A CG  1 
ATOM   1837 C CD  . PRO A 1 246 ? 10.32458  9.74782   18.45514  1.000 41.73792 ? 598 PRO A CD  1 
ATOM   1838 N N   . ARG A 1 247 ? 12.27930  10.40622  14.18374  1.000 34.97723 ? 599 ARG A N   1 
ATOM   1839 C CA  . ARG A 1 247 ? 11.98242  10.20705  12.76940  1.000 36.55782 ? 599 ARG A CA  1 
ATOM   1840 C C   . ARG A 1 247 ? 11.97878  8.72878   12.41205  1.000 39.47610 ? 599 ARG A C   1 
ATOM   1841 O O   . ARG A 1 247 ? 11.10910  8.26505   11.66106  1.000 34.44376 ? 599 ARG A O   1 
ATOM   1842 C CB  . ARG A 1 247 ? 12.98277  10.96526  11.90393  1.000 43.61878 ? 599 ARG A CB  1 
ATOM   1843 C CG  . ARG A 1 247 ? 12.86021  10.66070  10.42943  1.000 41.56644 ? 599 ARG A CG  1 
ATOM   1844 C CD  . ARG A 1 247 ? 11.53789  11.12421  9.85151   1.000 55.42259 ? 599 ARG A CD  1 
ATOM   1845 N NE  . ARG A 1 247 ? 11.56766  11.02546  8.39715   1.000 61.77510 ? 599 ARG A NE  1 
ATOM   1846 C CZ  . ARG A 1 247 ? 12.11455  11.93052  7.59379   1.000 59.28419 ? 599 ARG A CZ  1 
ATOM   1847 N NH1 . ARG A 1 247 ? 12.63341  13.05463  8.06726   1.000 49.45782 ? 599 ARG A NH1 1 
ATOM   1848 N NH2 . ARG A 1 247 ? 12.14562  11.70022  6.28186   1.000 51.84135 ? 599 ARG A NH2 1 
ATOM   1849 N N   . GLU A 1 248 ? 12.93204  7.96973   12.95832  1.000 30.78941 ? 600 GLU A N   1 
ATOM   1850 C CA  . GLU A 1 248 ? 13.00079  6.54169   12.67481  1.000 36.27890 ? 600 GLU A CA  1 
ATOM   1851 C C   . GLU A 1 248 ? 11.74289  5.81774   13.14376  1.000 34.10870 ? 600 GLU A C   1 
ATOM   1852 O O   . GLU A 1 248 ? 11.32292  4.82806   12.53319  1.000 33.68300 ? 600 GLU A O   1 
ATOM   1853 C CB  . GLU A 1 248 ? 14.24164  5.95343   13.33629  1.000 39.89898 ? 600 GLU A CB  1 
ATOM   1854 C CG  . GLU A 1 248 ? 15.55145  6.53980   12.80634  1.000 47.68124 ? 600 GLU A CG  1 
ATOM   1855 C CD  . GLU A 1 248 ? 15.95897  7.85149   13.48257  1.000 45.50356 ? 600 GLU A CD  1 
ATOM   1856 O OE1 . GLU A 1 248 ? 15.08732  8.61324   13.94990  1.000 47.15982 ? 600 GLU A OE1 1 
ATOM   1857 O OE2 . GLU A 1 248 ? 17.17570  8.11932   13.55560  1.000 66.02279 ? 600 GLU A OE2 1 
ATOM   1858 N N   . MET A 1 249 ? 11.11660  6.30628   14.20499  1.000 33.19005 ? 601 MET A N   1 
ATOM   1859 C CA  . MET A 1 249 ? 9.89274   5.67203   14.67062  1.000 34.07090 ? 601 MET A CA  1 
ATOM   1860 C C   . MET A 1 249 ? 8.72548   5.99995   13.75451  1.000 26.29013 ? 601 MET A C   1 
ATOM   1861 O O   . MET A 1 249 ? 7.84961   5.15787   13.53240  1.000 30.19342 ? 601 MET A O   1 
ATOM   1862 C CB  . MET A 1 249 ? 9.60288   6.10176   16.09781  1.000 30.97450 ? 601 MET A CB  1 
ATOM   1863 C CG  . MET A 1 249 ? 10.67577  5.65636   17.08626  1.000 29.17731 ? 601 MET A CG  1 
ATOM   1864 S SD  . MET A 1 249 ? 10.78460  3.85619   17.23601  1.000 37.57499 ? 601 MET A SD  1 
ATOM   1865 C CE  . MET A 1 249 ? 9.28966   3.54339   18.15334  1.000 49.62064 ? 601 MET A CE  1 
ATOM   1866 N N   . TYR A 1 250 ? 8.68312   7.22163   13.22287  1.000 35.77099 ? 602 TYR A N   1 
ATOM   1867 C CA  . TYR A 1 250 ? 7.62991   7.53377   12.26664  1.000 33.23870 ? 602 TYR A CA  1 
ATOM   1868 C C   . TYR A 1 250 ? 7.82817   6.76522   10.96325  1.000 35.19390 ? 602 TYR A C   1 
ATOM   1869 O O   . TYR A 1 250 ? 6.84579   6.33763   10.33530  1.000 26.20283 ? 602 TYR A O   1 
ATOM   1870 C CB  . TYR A 1 250 ? 7.55344   9.03969   12.01349  1.000 28.49344 ? 602 TYR A CB  1 
ATOM   1871 C CG  . TYR A 1 250 ? 6.42967   9.37754   11.05300  1.000 33.82161 ? 602 TYR A CG  1 
ATOM   1872 C CD1 . TYR A 1 250 ? 5.10123   9.10634   11.39076  1.000 26.35457 ? 602 TYR A CD1 1 
ATOM   1873 C CD2 . TYR A 1 250 ? 6.69304   9.93698   9.81663   1.000 33.56386 ? 602 TYR A CD2 1 
ATOM   1874 C CE1 . TYR A 1 250 ? 4.06925   9.39549   10.51621  1.000 26.94772 ? 602 TYR A CE1 1 
ATOM   1875 C CE2 . TYR A 1 250 ? 5.67194   10.24301  8.94035   1.000 33.27096 ? 602 TYR A CE2 1 
ATOM   1876 C CZ  . TYR A 1 250 ? 4.36583   9.96777   9.29507   1.000 34.69141 ? 602 TYR A CZ  1 
ATOM   1877 O OH  . TYR A 1 250 ? 3.35087   10.25282  8.41524   1.000 32.55190 ? 602 TYR A OH  1 
ATOM   1878 N N   . ASP A 1 251 ? 9.08999   6.56203   10.54625  1.000 30.74909 ? 603 ASP A N   1 
ATOM   1879 C CA  . ASP A 1 251 ? 9.35595   5.71488   9.38455   1.000 26.14828 ? 603 ASP A CA  1 
ATOM   1880 C C   . ASP A 1 251 ? 8.88542   4.28963   9.63079   1.000 28.45025 ? 603 ASP A C   1 
ATOM   1881 O O   . ASP A 1 251 ? 8.38330   3.62254   8.71924   1.000 32.24356 ? 603 ASP A O   1 
ATOM   1882 C CB  . ASP A 1 251 ? 10.85521  5.69719   9.04993   1.000 32.68729 ? 603 ASP A CB  1 
ATOM   1883 C CG  . ASP A 1 251 ? 11.38874  7.05420   8.64596   1.000 35.56209 ? 603 ASP A CG  1 
ATOM   1884 O OD1 . ASP A 1 251 ? 10.57687  7.93450   8.29350   1.000 35.35551 ? 603 ASP A OD1 1 
ATOM   1885 O OD2 . ASP A 1 251 ? 12.63250  7.23588   8.68966   1.000 39.14752 ? 603 ASP A OD2 1 
ATOM   1886 N N   . LEU A 1 252 ? 9.06372   3.78803   10.85453  1.000 27.92797 ? 604 LEU A N   1 
ATOM   1887 C CA  . LEU A 1 252 ? 8.60061   2.43820   11.15648  1.000 28.87615 ? 604 LEU A CA  1 
ATOM   1888 C C   . LEU A 1 252 ? 7.07543   2.34390   11.09355  1.000 29.02547 ? 604 LEU A C   1 
ATOM   1889 O O   . LEU A 1 252 ? 6.52560   1.33254   10.62885  1.000 28.50988 ? 604 LEU A O   1 
ATOM   1890 C CB  . LEU A 1 252 ? 9.10756   2.01282   12.53768  1.000 31.96596 ? 604 LEU A CB  1 
ATOM   1891 C CG  . LEU A 1 252 ? 8.65816   0.62923   12.99121  1.000 27.70587 ? 604 LEU A CG  1 
ATOM   1892 C CD1 . LEU A 1 252 ? 9.08044   -0.44592  11.98886  1.000 32.48349 ? 604 LEU A CD1 1 
ATOM   1893 C CD2 . LEU A 1 252 ? 9.24411   0.34968   14.35892  1.000 32.35999 ? 604 LEU A CD2 1 
ATOM   1894 N N   . MET A 1 253 ? 6.37405   3.37394   11.58053  1.000 25.46510 ? 605 MET A N   1 
ATOM   1895 C CA  . MET A 1 253 ? 4.91395   3.39161   11.47177  1.000 27.67393 ? 605 MET A CA  1 
ATOM   1896 C C   . MET A 1 253 ? 4.47874   3.26873   10.02039  1.000 26.24187 ? 605 MET A C   1 
ATOM   1897 O O   . MET A 1 253 ? 3.60103   2.46627   9.68518   1.000 26.71042 ? 605 MET A O   1 
ATOM   1898 C CB  . MET A 1 253 ? 4.33889   4.68102   12.06595  1.000 24.82244 ? 605 MET A CB  1 
ATOM   1899 C CG  . MET A 1 253 ? 4.53298   4.86996   13.53891  1.000 25.03771 ? 605 MET A CG  1 
ATOM   1900 S SD  . MET A 1 253 ? 4.08237   6.56421   13.95759  1.000 31.50445 ? 605 MET A SD  1 
ATOM   1901 C CE  . MET A 1 253 ? 4.95715   6.68235   15.51388  1.000 30.32668 ? 605 MET A CE  1 
ATOM   1902 N N   . ASN A 1 254 ? 5.09327   4.05228   9.13730   1.000 31.83221 ? 606 ASN A N   1 
ATOM   1903 C CA  . ASN A 1 254 ? 4.72906   3.96916   7.72755   1.000 28.56099 ? 606 ASN A CA  1 
ATOM   1904 C C   . ASN A 1 254 ? 5.03697   2.59202   7.13794   1.000 24.58063 ? 606 ASN A C   1 
ATOM   1905 O O   . ASN A 1 254 ? 4.31900   2.12025   6.24781   1.000 27.63059 ? 606 ASN A O   1 
ATOM   1906 C CB  . ASN A 1 254 ? 5.42865   5.07017   6.93512   1.000 28.33689 ? 606 ASN A CB  1 
ATOM   1907 C CG  . ASN A 1 254 ? 4.59361   6.34424   6.84606   1.000 31.13419 ? 606 ASN A CG  1 
ATOM   1908 O OD1 . ASN A 1 254 ? 3.51372   6.34852   6.25641   1.000 35.65557 ? 606 ASN A OD1 1 
ATOM   1909 N ND2 . ASN A 1 254 ? 5.09300   7.42718   7.42948   1.000 37.94902 ? 606 ASN A ND2 1 
ATOM   1910 N N   . LEU A 1 255 ? 6.07178   1.92058   7.62543   1.000 28.30950 ? 607 LEU A N   1 
ATOM   1911 C CA  . LEU A 1 255 ? 6.30969   0.55646   7.16150   1.000 27.60580 ? 607 LEU A CA  1 
ATOM   1912 C C   . LEU A 1 255 ? 5.23054   -0.39280  7.67894   1.000 30.96190 ? 607 LEU A C   1 
ATOM   1913 O O   . LEU A 1 255 ? 4.81901   -1.32733  6.97512   1.000 27.91505 ? 607 LEU A O   1 
ATOM   1914 C CB  . LEU A 1 255 ? 7.70524   0.10553   7.58656   1.000 31.03499 ? 607 LEU A CB  1 
ATOM   1915 C CG  . LEU A 1 255 ? 8.11038   -1.31662  7.20257   1.000 33.62502 ? 607 LEU A CG  1 
ATOM   1916 C CD1 . LEU A 1 255 ? 8.05948   -1.49814  5.68528   1.000 35.22821 ? 607 LEU A CD1 1 
ATOM   1917 C CD2 . LEU A 1 255 ? 9.50006   -1.64516  7.76455   1.000 32.64399 ? 607 LEU A CD2 1 
ATOM   1918 N N   . CYS A 1 256 ? 4.76200   -0.17675  8.91079   1.000 28.70334 ? 608 CYS A N   1 
ATOM   1919 C CA  . CYS A 1 256 ? 3.63984   -0.96604  9.40586   1.000 27.25962 ? 608 CYS A CA  1 
ATOM   1920 C C   . CYS A 1 256 ? 2.39252   -0.73670  8.56287   1.000 25.92781 ? 608 CYS A C   1 
ATOM   1921 O O   . CYS A 1 256 ? 1.59551   -1.66151  8.36861   1.000 27.23543 ? 608 CYS A O   1 
ATOM   1922 C CB  . CYS A 1 256 ? 3.36180   -0.64313  10.87494  1.000 22.15169 ? 608 CYS A CB  1 
ATOM   1923 S SG  . CYS A 1 256 ? 4.64045   -1.23773  12.01488  1.000 30.39150 ? 608 CYS A SG  1 
ATOM   1924 N N   . TRP A 1 257 ? 2.22561   0.46895   8.02616   1.000 24.86603 ? 609 TRP A N   1 
ATOM   1925 C CA  . TRP A 1 257 ? 1.08550   0.81418   7.17489   1.000 24.57178 ? 609 TRP A CA  1 
ATOM   1926 C C   . TRP A 1 257 ? 1.35722   0.51525   5.71650   1.000 28.46622 ? 609 TRP A C   1 
ATOM   1927 O O   . TRP A 1 257 ? 0.96306   1.29649   4.84513   1.000 30.06755 ? 609 TRP A O   1 
ATOM   1928 C CB  . TRP A 1 257 ? 0.72591   2.28769   7.34916   1.000 26.15774 ? 609 TRP A CB  1 
ATOM   1929 C CG  . TRP A 1 257 ? 0.44092   2.67455   8.76781   1.000 26.80093 ? 609 TRP A CG  1 
ATOM   1930 C CD1 . TRP A 1 257 ? -0.07967  1.88374   9.73912   1.000 25.80061 ? 609 TRP A CD1 1 
ATOM   1931 C CD2 . TRP A 1 257 ? 0.66318   3.95670   9.36108   1.000 20.57389 ? 609 TRP A CD2 1 
ATOM   1932 N NE1 . TRP A 1 257 ? -0.19244  2.58540   10.90970  1.000 29.04819 ? 609 TRP A NE1 1 
ATOM   1933 C CE2 . TRP A 1 257 ? 0.25702   3.86792   10.70096  1.000 28.01805 ? 609 TRP A CE2 1 
ATOM   1934 C CE3 . TRP A 1 257 ? 1.18032   5.16594   8.88955   1.000 27.46719 ? 609 TRP A CE3 1 
ATOM   1935 C CZ2 . TRP A 1 257 ? 0.35465   4.94315   11.58752  1.000 24.68344 ? 609 TRP A CZ2 1 
ATOM   1936 C CZ3 . TRP A 1 257 ? 1.26857   6.23965   9.76540   1.000 27.10645 ? 609 TRP A CZ3 1 
ATOM   1937 C CH2 . TRP A 1 257 ? 0.84201   6.12270   11.10163  1.000 23.83613 ? 609 TRP A CH2 1 
ATOM   1938 N N   . THR A 1 258 ? 2.06915   -0.57417  5.43302   1.000 28.47336 ? 610 THR A N   1 
ATOM   1939 C CA  . THR A 1 258 ? 2.24039   -1.03739  4.06652   1.000 26.21852 ? 610 THR A CA  1 
ATOM   1940 C C   . THR A 1 258 ? 0.91162   -1.58084  3.56515   1.000 25.63374 ? 610 THR A C   1 
ATOM   1941 O O   . THR A 1 258 ? 0.34785   -2.49718  4.17195   1.000 29.68438 ? 610 THR A O   1 
ATOM   1942 C CB  . THR A 1 258 ? 3.30851   -2.12742  3.98704   1.000 30.70012 ? 610 THR A CB  1 
ATOM   1943 O OG1 . THR A 1 258 ? 4.60632   -1.60220  4.31727   1.000 27.78191 ? 610 THR A OG1 1 
ATOM   1944 C CG2 . THR A 1 258 ? 3.33471   -2.74802  2.58897   1.000 29.49260 ? 610 THR A CG2 1 
ATOM   1945 N N   . TYR A 1 259 ? 0.42535   -1.04307  2.44444   1.000 23.33807 ? 611 TYR A N   1 
ATOM   1946 C CA  . TYR A 1 259 ? -0.84928  -1.50839  1.89899   1.000 26.72651 ? 611 TYR A CA  1 
ATOM   1947 C C   . TYR A 1 259 ? -0.83353  -3.01529  1.62033   1.000 33.19048 ? 611 TYR A C   1 
ATOM   1948 O O   . TYR A 1 259 ? -1.77974  -3.73274  1.97354   1.000 33.36318 ? 611 TYR A O   1 
ATOM   1949 C CB  . TYR A 1 259 ? -1.20848  -0.73883  0.61914   1.000 27.50538 ? 611 TYR A CB  1 
ATOM   1950 C CG  . TYR A 1 259 ? -2.67422  -0.94036  0.22997   1.000 32.27967 ? 611 TYR A CG  1 
ATOM   1951 C CD1 . TYR A 1 259 ? -3.66960  -0.11999  0.76025   1.000 31.05531 ? 611 TYR A CD1 1 
ATOM   1952 C CD2 . TYR A 1 259 ? -3.06276  -1.96723  -0.63189  1.000 33.07216 ? 611 TYR A CD2 1 
ATOM   1953 C CE1 . TYR A 1 259 ? -4.99099  -0.29674  0.42675   1.000 34.81774 ? 611 TYR A CE1 1 
ATOM   1954 C CE2 . TYR A 1 259 ? -4.40754  -2.15278  -0.97232  1.000 33.68063 ? 611 TYR A CE2 1 
ATOM   1955 C CZ  . TYR A 1 259 ? -5.35879  -1.31022  -0.43270  1.000 36.59363 ? 611 TYR A CZ  1 
ATOM   1956 O OH  . TYR A 1 259 ? -6.70457  -1.44699  -0.73460  1.000 42.21826 ? 611 TYR A OH  1 
ATOM   1957 N N   . ASP A 1 260 ? 0.22111   -3.51234  0.98252   1.000 28.65794 ? 612 ASP A N   1 
ATOM   1958 C CA  . ASP A 1 260 ? 0.24147   -4.90725  0.53953   1.000 30.90679 ? 612 ASP A CA  1 
ATOM   1959 C C   . ASP A 1 260 ? 0.61642   -5.83142  1.69253   1.000 32.13518 ? 612 ASP A C   1 
ATOM   1960 O O   . ASP A 1 260 ? 1.69078   -5.68709  2.28200   1.000 40.16752 ? 612 ASP A O   1 
ATOM   1961 C CB  . ASP A 1 260 ? 1.22083   -5.08710  -0.61839  1.000 45.11799 ? 612 ASP A CB  1 
ATOM   1962 C CG  . ASP A 1 260 ? 1.07633   -6.44870  -1.30341  1.000 47.56420 ? 612 ASP A CG  1 
ATOM   1963 O OD1 . ASP A 1 260 ? 0.70970   -7.44099  -0.62998  1.000 47.77998 ? 612 ASP A OD1 1 
ATOM   1964 O OD2 . ASP A 1 260 ? 1.32360   -6.51982  -2.52260  1.000 41.93326 ? 612 ASP A OD2 1 
ATOM   1965 N N   . VAL A 1 261 ? -0.24436  -6.81760  1.97305   1.000 35.97934 ? 613 VAL A N   1 
ATOM   1966 C CA  . VAL A 1 261 ? -0.00164  -7.73625  3.08510   1.000 45.99493 ? 613 VAL A CA  1 
ATOM   1967 C C   . VAL A 1 261 ? 1.35203   -8.41411  2.95038   1.000 40.91803 ? 613 VAL A C   1 
ATOM   1968 O O   . VAL A 1 261 ? 2.10166   -8.52060  3.92395   1.000 34.23450 ? 613 VAL A O   1 
ATOM   1969 C CB  . VAL A 1 261 ? -1.13444  -8.77543  3.19689   1.000 45.73481 ? 613 VAL A CB  1 
ATOM   1970 C CG1 . VAL A 1 261 ? -2.33811  -8.12290  3.69606   1.000 44.10264 ? 613 VAL A CG1 1 
ATOM   1971 C CG2 . VAL A 1 261 ? -1.44111  -9.43501  1.85319   1.000 43.50531 ? 613 VAL A CG2 1 
ATOM   1972 N N   . GLU A 1 262 ? 1.69878   -8.86755  1.74312   1.000 48.58358 ? 614 GLU A N   1 
ATOM   1973 C CA  . GLU A 1 262 ? 2.91927   -9.65410  1.58617   1.000 45.62736 ? 614 GLU A CA  1 
ATOM   1974 C C   . GLU A 1 262 ? 4.16633   -8.80822  1.78281   1.000 36.83122 ? 614 GLU A C   1 
ATOM   1975 O O   . GLU A 1 262 ? 5.18927   -9.32047  2.24561   1.000 47.96497 ? 614 GLU A O   1 
ATOM   1976 C CB  . GLU A 1 262 ? 2.93376   -10.32714 0.21630   1.000 40.60660 ? 614 GLU A CB  1 
ATOM   1977 C CG  . GLU A 1 262 ? 1.58863   -10.90606 -0.19101  1.000 51.44744 ? 614 GLU A CG  1 
ATOM   1978 C CD  . GLU A 1 262 ? 1.09335   -12.00940 0.73658   1.000 59.72517 ? 614 GLU A CD  1 
ATOM   1979 O OE1 . GLU A 1 262 ? 1.90561   -12.58805 1.49569   1.000 61.19344 ? 614 GLU A OE1 1 
ATOM   1980 O OE2 . GLU A 1 262 ? -0.12252  -12.30136 0.70287   1.000 62.43673 ? 614 GLU A OE2 1 
ATOM   1981 N N   . ASN A 1 263 ? 4.09844   -7.51815  1.45139   1.000 34.19110 ? 615 ASN A N   1 
ATOM   1982 C CA  . ASN A 1 263 ? 5.22736   -6.61422  1.63400   1.000 43.93642 ? 615 ASN A CA  1 
ATOM   1983 C C   . ASN A 1 263 ? 5.33464   -6.07436  3.05694   1.000 36.58759 ? 615 ASN A C   1 
ATOM   1984 O O   . ASN A 1 263 ? 6.42068   -5.65909  3.46778   1.000 38.60295 ? 615 ASN A O   1 
ATOM   1985 C CB  . ASN A 1 263 ? 5.12233   -5.44614  0.64557   1.000 41.13583 ? 615 ASN A CB  1 
ATOM   1986 C CG  . ASN A 1 263 ? 5.07307   -5.90919  -0.79680  1.000 51.92807 ? 615 ASN A CG  1 
ATOM   1987 O OD1 . ASN A 1 263 ? 5.65448   -6.93057  -1.14326  1.000 47.38470 ? 615 ASN A OD1 1 
ATOM   1988 N ND2 . ASN A 1 263 ? 4.37936   -5.15705  -1.64508  1.000 55.01055 ? 615 ASN A ND2 1 
ATOM   1989 N N   . ARG A 1 264 ? 4.24195   -6.05581  3.80643   1.000 39.16539 ? 616 ARG A N   1 
ATOM   1990 C CA  . ARG A 1 264 ? 4.27843   -5.53487  5.16691   1.000 34.27460 ? 616 ARG A CA  1 
ATOM   1991 C C   . ARG A 1 264 ? 5.15676   -6.43495  6.03795   1.000 31.04157 ? 616 ARG A C   1 
ATOM   1992 O O   . ARG A 1 264 ? 5.13265   -7.65979  5.88137   1.000 34.36505 ? 616 ARG A O   1 
ATOM   1993 C CB  . ARG A 1 264 ? 2.85060   -5.48028  5.72825   1.000 33.30454 ? 616 ARG A CB  1 
ATOM   1994 C CG  . ARG A 1 264 ? 2.63590   -4.62510  6.98242   1.000 31.39642 ? 616 ARG A CG  1 
ATOM   1995 C CD  . ARG A 1 264 ? 1.18799   -4.76939  7.44230   1.000 28.66217 ? 616 ARG A CD  1 
ATOM   1996 N NE  . ARG A 1 264 ? 0.26723   -4.38523  6.37033   1.000 25.03891 ? 616 ARG A NE  1 
ATOM   1997 C CZ  . ARG A 1 264 ? -0.92851  -4.92823  6.16413   1.000 27.69948 ? 616 ARG A CZ  1 
ATOM   1998 N NH1 . ARG A 1 264 ? -1.41722  -5.86437  6.96691   1.000 25.49320 ? 616 ARG A NH1 1 
ATOM   1999 N NH2 . ARG A 1 264 ? -1.65174  -4.52650  5.12049   1.000 27.79636 ? 616 ARG A NH2 1 
ATOM   2000 N N   . PRO A 1 265 ? 5.92988   -5.87783  6.96157   1.000 29.90831 ? 617 PRO A N   1 
ATOM   2001 C CA  . PRO A 1 265 ? 6.73453   -6.72881  7.85114   1.000 32.67479 ? 617 PRO A CA  1 
ATOM   2002 C C   . PRO A 1 265 ? 5.88179   -7.52586  8.83774   1.000 34.67477 ? 617 PRO A C   1 
ATOM   2003 O O   . PRO A 1 265 ? 4.77997   -7.12186  9.21162   1.000 35.79118 ? 617 PRO A O   1 
ATOM   2004 C CB  . PRO A 1 265 ? 7.62742   -5.72434  8.58648   1.000 32.72544 ? 617 PRO A CB  1 
ATOM   2005 C CG  . PRO A 1 265 ? 6.86311   -4.40769  8.52664   1.000 26.83223 ? 617 PRO A CG  1 
ATOM   2006 C CD  . PRO A 1 265 ? 6.16149   -4.43555  7.18998   1.000 26.69558 ? 617 PRO A CD  1 
ATOM   2007 N N   . GLY A 1 266 ? 6.40987   -8.68440  9.25032   1.000 29.10363 ? 618 GLY A N   1 
ATOM   2008 C CA  . GLY A 1 266 ? 5.91976   -9.38729  10.42173  1.000 32.39849 ? 618 GLY A CA  1 
ATOM   2009 C C   . GLY A 1 266 ? 6.48390   -8.82456  11.73035  1.000 35.10059 ? 618 GLY A C   1 
ATOM   2010 O O   . GLY A 1 266 ? 7.26688   -7.87134  11.76125  1.000 31.94330 ? 618 GLY A O   1 
ATOM   2011 N N   . PHE A 1 267 ? 6.07127   -9.43818  12.84459  1.000 26.45685 ? 619 PHE A N   1 
ATOM   2012 C CA  . PHE A 1 267 ? 6.53369   -8.93826  14.13051  1.000 25.37994 ? 619 PHE A CA  1 
ATOM   2013 C C   . PHE A 1 267 ? 7.99261   -9.28545  14.39615  1.000 30.21815 ? 619 PHE A C   1 
ATOM   2014 O O   . PHE A 1 267 ? 8.66352   -8.55646  15.12787  1.000 31.45417 ? 619 PHE A O   1 
ATOM   2015 C CB  . PHE A 1 267 ? 5.63444   -9.43519  15.25567  1.000 26.99883 ? 619 PHE A CB  1 
ATOM   2016 C CG  . PHE A 1 267 ? 4.42369   -8.57688  15.43615  1.000 27.63502 ? 619 PHE A CG  1 
ATOM   2017 C CD1 . PHE A 1 267 ? 4.54692   -7.28826  15.93106  1.000 29.68708 ? 619 PHE A CD1 1 
ATOM   2018 C CD2 . PHE A 1 267 ? 3.17504   -9.02838  15.05084  1.000 28.59482 ? 619 PHE A CD2 1 
ATOM   2019 C CE1 . PHE A 1 267 ? 3.42933   -6.47846  16.06429  1.000 26.43949 ? 619 PHE A CE1 1 
ATOM   2020 C CE2 . PHE A 1 267 ? 2.06767   -8.22527  15.18883  1.000 26.16102 ? 619 PHE A CE2 1 
ATOM   2021 C CZ  . PHE A 1 267 ? 2.19977   -6.95454  15.69727  1.000 27.60236 ? 619 PHE A CZ  1 
ATOM   2022 N N   . ALA A 1 268 ? 8.51884   -10.35875 13.79938  1.000 30.47764 ? 620 ALA A N   1 
ATOM   2023 C CA  . ALA A 1 268 ? 9.95928   -10.59710 13.91896  1.000 35.92734 ? 620 ALA A CA  1 
ATOM   2024 C C   . ALA A 1 268 ? 10.75411  -9.39412  13.41338  1.000 33.32755 ? 620 ALA A C   1 
ATOM   2025 O O   . ALA A 1 268 ? 11.60518  -8.84490  14.12805  1.000 30.51571 ? 620 ALA A O   1 
ATOM   2026 C CB  . ALA A 1 268 ? 10.35578  -11.86710 13.16201  1.000 40.44479 ? 620 ALA A CB  1 
ATOM   2027 N N   . ALA A 1 269 ? 10.46696  -8.95082  12.18739  1.000 34.12775 ? 621 ALA A N   1 
ATOM   2028 C CA  . ALA A 1 269 ? 11.18899  -7.81772  11.62316  1.000 31.99754 ? 621 ALA A CA  1 
ATOM   2029 C C   . ALA A 1 269 ? 10.92030  -6.54328  12.41260  1.000 34.33512 ? 621 ALA A C   1 
ATOM   2030 O O   . ALA A 1 269 ? 11.83862  -5.74860  12.64570  1.000 34.16493 ? 621 ALA A O   1 
ATOM   2031 C CB  . ALA A 1 269 ? 10.80538  -7.63402  10.15211  1.000 33.77698 ? 621 ALA A CB  1 
ATOM   2032 N N   . VAL A 1 270 ? 9.66701   -6.33740  12.84294  1.000 26.93923 ? 622 VAL A N   1 
ATOM   2033 C CA  . VAL A 1 270 ? 9.30684   -5.13046  13.59275  1.000 27.51481 ? 622 VAL A CA  1 
ATOM   2034 C C   . VAL A 1 270 ? 10.05807  -5.07378  14.92069  1.000 28.68026 ? 622 VAL A C   1 
ATOM   2035 O O   . VAL A 1 270 ? 10.60437  -4.03101  15.30310  1.000 32.38225 ? 622 VAL A O   1 
ATOM   2036 C CB  . VAL A 1 270 ? 7.78450   -5.07119  13.82734  1.000 30.61909 ? 622 VAL A CB  1 
ATOM   2037 C CG1 . VAL A 1 270 ? 7.46772   -3.98742  14.86270  1.000 27.28652 ? 622 VAL A CG1 1 
ATOM   2038 C CG2 . VAL A 1 270 ? 7.03885   -4.82490  12.50015  1.000 27.91601 ? 622 VAL A CG2 1 
ATOM   2039 N N   . GLU A 1 271 ? 10.04280  -6.18120  15.66854  1.000 31.33719 ? 623 GLU A N   1 
ATOM   2040 C CA  . GLU A 1 271 ? 10.74215  -6.22718  16.95201  1.000 31.83404 ? 623 GLU A CA  1 
ATOM   2041 C C   . GLU A 1 271 ? 12.22370  -5.89755  16.77737  1.000 34.98945 ? 623 GLU A C   1 
ATOM   2042 O O   . GLU A 1 271 ? 12.78464  -5.08603  17.52438  1.000 33.11327 ? 623 GLU A O   1 
ATOM   2043 C CB  . GLU A 1 271 ? 10.55684  -7.60706  17.58968  1.000 28.71733 ? 623 GLU A CB  1 
ATOM   2044 C CG  . GLU A 1 271 ? 11.06667  -7.74382  19.02701  1.000 25.59104 ? 623 GLU A CG  1 
ATOM   2045 C CD  . GLU A 1 271 ? 12.56904  -8.02125  19.10174  1.000 44.74856 ? 623 GLU A CD  1 
ATOM   2046 O OE1 . GLU A 1 271 ? 13.09956  -8.65463  18.16163  1.000 39.46678 ? 623 GLU A OE1 1 
ATOM   2047 O OE2 . GLU A 1 271 ? 13.21287  -7.60164  20.09360  1.000 37.80700 ? 623 GLU A OE2 1 
ATOM   2048 N N   . LEU A 1 272 ? 12.86592  -6.50598  15.77556  1.000 37.15957 ? 624 LEU A N   1 
ATOM   2049 C CA  . LEU A 1 272 ? 14.29009  -6.26079  15.54417  1.000 39.97012 ? 624 LEU A CA  1 
ATOM   2050 C C   . LEU A 1 272 ? 14.56229  -4.79142  15.24444  1.000 41.35365 ? 624 LEU A C   1 
ATOM   2051 O O   . LEU A 1 272 ? 15.53298  -4.21243  15.75170  1.000 42.13141 ? 624 LEU A O   1 
ATOM   2052 C CB  . LEU A 1 272 ? 14.78376  -7.14022  14.39848  1.000 38.63220 ? 624 LEU A CB  1 
ATOM   2053 C CG  . LEU A 1 272 ? 16.30313  -7.16522  14.22482  1.000 51.58376 ? 624 LEU A CG  1 
ATOM   2054 C CD1 . LEU A 1 272 ? 16.94266  -7.94385  15.37381  1.000 55.31787 ? 624 LEU A CD1 1 
ATOM   2055 C CD2 . LEU A 1 272 ? 16.68011  -7.75903  12.88361  1.000 46.57647 ? 624 LEU A CD2 1 
ATOM   2056 N N   . ARG A 1 273 ? 13.70796  -4.16637  14.42673  1.000 38.95824 ? 625 ARG A N   1 
ATOM   2057 C CA  . ARG A 1 273 ? 13.87159  -2.74797  14.12895  1.000 38.66317 ? 625 ARG A CA  1 
ATOM   2058 C C   . ARG A 1 273 ? 13.78597  -1.90165  15.39678  1.000 38.52130 ? 625 ARG A C   1 
ATOM   2059 O O   . ARG A 1 273 ? 14.59331  -0.98394  15.59878  1.000 37.03993 ? 625 ARG A O   1 
ATOM   2060 C CB  . ARG A 1 273 ? 12.82001  -2.31795  13.10562  1.000 41.12492 ? 625 ARG A CB  1 
ATOM   2061 C CG  . ARG A 1 273 ? 13.35092  -1.40722  12.02516  1.000 58.22503 ? 625 ARG A CG  1 
ATOM   2062 C CD  . ARG A 1 273 ? 13.18640  0.04397   12.43496  1.000 58.92385 ? 625 ARG A CD  1 
ATOM   2063 N NE  . ARG A 1 273 ? 14.11021  0.93131   11.73653  1.000 64.09594 ? 625 ARG A NE  1 
ATOM   2064 C CZ  . ARG A 1 273 ? 15.33595  1.21225   12.15941  1.000 64.70540 ? 625 ARG A CZ  1 
ATOM   2065 N NH1 . ARG A 1 273 ? 15.83888  0.64947   13.25265  1.000 52.80421 ? 625 ARG A NH1 1 
ATOM   2066 N NH2 . ARG A 1 273 ? 16.07520  2.08083   11.47246  1.000 70.58684 ? 625 ARG A NH2 1 
ATOM   2067 N N   . LEU A 1 274 ? 12.82390  -2.20229  16.27668  1.000 31.99505 ? 626 LEU A N   1 
ATOM   2068 C CA  . LEU A 1 274 ? 12.72395  -1.46284  17.52932  1.000 30.69851 ? 626 LEU A CA  1 
ATOM   2069 C C   . LEU A 1 274 ? 13.91670  -1.73634  18.44045  1.000 35.75080 ? 626 LEU A C   1 
ATOM   2070 O O   . LEU A 1 274 ? 14.40662  -0.82428  19.12011  1.000 33.25891 ? 626 LEU A O   1 
ATOM   2071 C CB  . LEU A 1 274 ? 11.42528  -1.82274  18.25145  1.000 26.97015 ? 626 LEU A CB  1 
ATOM   2072 C CG  . LEU A 1 274 ? 10.14944  -1.25572  17.64232  1.000 31.55911 ? 626 LEU A CG  1 
ATOM   2073 C CD1 . LEU A 1 274 ? 8.94977   -1.82777  18.35663  1.000 33.71847 ? 626 LEU A CD1 1 
ATOM   2074 C CD2 . LEU A 1 274 ? 10.16121  0.24550   17.77587  1.000 30.55052 ? 626 LEU A CD2 1 
ATOM   2075 N N   . ARG A 1 275 ? 14.35573  -2.99591  18.51409  1.000 32.03030 ? 627 ARG A N   1 
ATOM   2076 C CA  . ARG A 1 275 ? 15.51390  -3.32260  19.33929  1.000 35.26535 ? 627 ARG A CA  1 
ATOM   2077 C C   . ARG A 1 275 ? 16.75822  -2.58750  18.85144  1.000 40.19207 ? 627 ARG A C   1 
ATOM   2078 O O   . ARG A 1 275 ? 17.52556  -2.04847  19.65943  1.000 45.17107 ? 627 ARG A O   1 
ATOM   2079 C CB  . ARG A 1 275 ? 15.75629  -4.83371  19.34047  1.000 33.35687 ? 627 ARG A CB  1 
ATOM   2080 C CG  . ARG A 1 275 ? 16.74983  -5.28254  20.40971  1.000 41.94984 ? 627 ARG A CG  1 
ATOM   2081 C CD  . ARG A 1 275 ? 17.31617  -6.64894  20.10341  1.000 40.32581 ? 627 ARG A CD  1 
ATOM   2082 N NE  . ARG A 1 275 ? 16.29329  -7.55015  19.59105  1.000 54.55044 ? 627 ARG A NE  1 
ATOM   2083 C CZ  . ARG A 1 275 ? 16.53776  -8.74827  19.07152  1.000 62.65447 ? 627 ARG A CZ  1 
ATOM   2084 N NH1 . ARG A 1 275 ? 17.77422  -9.21053  18.94198  1.000 48.19984 ? 627 ARG A NH1 1 
ATOM   2085 N NH2 . ARG A 1 275 ? 15.51671  -9.50730  18.68097  1.000 43.66010 ? 627 ARG A NH2 1 
ATOM   2086 N N   . ASN A 1 276 ? 16.97568  -2.55230  17.52997  1.000 38.29360 ? 628 ASN A N   1 
ATOM   2087 C CA  . ASN A 1 276 ? 18.15313  -1.86583  16.99474  1.000 35.89652 ? 628 ASN A CA  1 
ATOM   2088 C C   . ASN A 1 276 ? 18.08303  -0.36434  17.23802  1.000 47.26266 ? 628 ASN A C   1 
ATOM   2089 O O   . ASN A 1 276 ? 19.10351  0.26609   17.54825  1.000 45.03728 ? 628 ASN A O   1 
ATOM   2090 C CB  . ASN A 1 276 ? 18.31094  -2.14007  15.49761  1.000 47.77808 ? 628 ASN A CB  1 
ATOM   2091 C CG  . ASN A 1 276 ? 18.70160  -3.57403  15.20052  1.000 44.90175 ? 628 ASN A CG  1 
ATOM   2092 O OD1 . ASN A 1 276 ? 19.13466  -4.30337  16.08490  1.000 57.02578 ? 628 ASN A OD1 1 
ATOM   2093 N ND2 . ASN A 1 276 ? 18.55041  -3.98099  13.94869  1.000 49.76375 ? 628 ASN A ND2 1 
ATOM   2094 N N   . TYR A 1 277 ? 16.89470  0.23493   17.09891  1.000 38.33697 ? 629 TYR A N   1 
ATOM   2095 C CA  . TYR A 1 277 ? 16.81306  1.68125   17.26265  1.000 37.29770 ? 629 TYR A CA  1 
ATOM   2096 C C   . TYR A 1 277 ? 16.90127  2.09995   18.72467  1.000 45.20117 ? 629 TYR A C   1 
ATOM   2097 O O   . TYR A 1 277 ? 17.46279  3.16045   19.02084  1.000 47.99723 ? 629 TYR A O   1 
ATOM   2098 C CB  . TYR A 1 277 ? 15.53311  2.25104   16.64673  1.000 36.52557 ? 629 TYR A CB  1 
ATOM   2099 C CG  . TYR A 1 277 ? 15.52453  3.75809   16.72919  1.000 37.84121 ? 629 TYR A CG  1 
ATOM   2100 C CD1 . TYR A 1 277 ? 16.45226  4.50665   16.01878  1.000 42.31890 ? 629 TYR A CD1 1 
ATOM   2101 C CD2 . TYR A 1 277 ? 14.62304  4.43170   17.53497  1.000 43.78773 ? 629 TYR A CD2 1 
ATOM   2102 C CE1 . TYR A 1 277 ? 16.47658  5.88223   16.10468  1.000 41.57779 ? 629 TYR A CE1 1 
ATOM   2103 C CE2 . TYR A 1 277 ? 14.63377  5.81547   17.61656  1.000 41.02431 ? 629 TYR A CE2 1 
ATOM   2104 C CZ  . TYR A 1 277 ? 15.56497  6.53085   16.89759  1.000 46.36107 ? 629 TYR A CZ  1 
ATOM   2105 O OH  . TYR A 1 277 ? 15.59761  7.90403   16.97520  1.000 42.91871 ? 629 TYR A OH  1 
ATOM   2106 N N   . TYR A 1 278 ? 16.36284  1.29630   19.64819  1.000 40.09101 ? 630 TYR A N   1 
ATOM   2107 C CA  . TYR A 1 278 ? 16.54423  1.59381   21.06587  1.000 37.48569 ? 630 TYR A CA  1 
ATOM   2108 C C   . TYR A 1 278 ? 18.01973  1.54142   21.44467  1.000 40.12430 ? 630 TYR A C   1 
ATOM   2109 O O   . TYR A 1 278 ? 18.51127  2.39124   22.19456  1.000 45.14946 ? 630 TYR A O   1 
ATOM   2110 C CB  . TYR A 1 278 ? 15.74272  0.61661   21.91863  1.000 38.18558 ? 630 TYR A CB  1 
ATOM   2111 C CG  . TYR A 1 278 ? 15.79403  0.92801   23.39850  1.000 43.62292 ? 630 TYR A CG  1 
ATOM   2112 C CD1 . TYR A 1 278 ? 14.97977  1.90951   23.95396  1.000 39.72022 ? 630 TYR A CD1 1 
ATOM   2113 C CD2 . TYR A 1 278 ? 16.65601  0.23854   24.24056  1.000 53.55737 ? 630 TYR A CD2 1 
ATOM   2114 C CE1 . TYR A 1 278 ? 15.02005  2.19209   25.30997  1.000 47.15332 ? 630 TYR A CE1 1 
ATOM   2115 C CE2 . TYR A 1 278 ? 16.70658  0.51557   25.59415  1.000 60.98756 ? 630 TYR A CE2 1 
ATOM   2116 C CZ  . TYR A 1 278 ? 15.88531  1.49218   26.12384  1.000 52.47236 ? 630 TYR A CZ  1 
ATOM   2117 O OH  . TYR A 1 278 ? 15.94344  1.76562   27.47088  1.000 53.76686 ? 630 TYR A OH  1 
ATOM   2118 N N   . TYR A 1 279 ? 18.73357  0.54177   20.93114  1.000 43.33617 ? 631 TYR A N   1 
ATOM   2119 C CA  . TYR A 1 279 ? 20.17224  0.43800   21.15552  1.000 50.29966 ? 631 TYR A CA  1 
ATOM   2120 C C   . TYR A 1 279 ? 20.89195  1.69470   20.66842  1.000 57.57716 ? 631 TYR A C   1 
ATOM   2121 O O   . TYR A 1 279 ? 21.80585  2.19721   21.33588  1.000 55.74264 ? 631 TYR A O   1 
ATOM   2122 C CB  . TYR A 1 279 ? 20.67299  -0.83883  20.46194  1.000 44.12502 ? 631 TYR A CB  1 
ATOM   2123 C CG  . TYR A 1 279 ? 22.17231  -1.05555  20.34802  1.000 58.54918 ? 631 TYR A CG  1 
ATOM   2124 C CD1 . TYR A 1 279 ? 22.91028  -1.55707  21.41535  1.000 60.72160 ? 631 TYR A CD1 1 
ATOM   2125 C CD2 . TYR A 1 279 ? 22.83812  -0.81535  19.14485  1.000 65.50652 ? 631 TYR A CD2 1 
ATOM   2126 C CE1 . TYR A 1 279 ? 24.28079  -1.77769  21.30030  1.000 63.98408 ? 631 TYR A CE1 1 
ATOM   2127 C CE2 . TYR A 1 279 ? 24.20612  -1.03342  19.01916  1.000 60.17649 ? 631 TYR A CE2 1 
ATOM   2128 C CZ  . TYR A 1 279 ? 24.91910  -1.51464  20.10115  1.000 65.55781 ? 631 TYR A CZ  1 
ATOM   2129 O OH  . TYR A 1 279 ? 26.27457  -1.73370  19.98887  1.000 73.21814 ? 631 TYR A OH  1 
ATOM   2130 N N   . ASP A 1 280 ? 20.44927  2.24898   19.53368  1.000 54.40868 ? 632 ASP A N   1 
ATOM   2131 C CA  . ASP A 1 280 ? 21.04932  3.46817   18.99553  1.000 53.40402 ? 632 ASP A CA  1 
ATOM   2132 C C   . ASP A 1 280 ? 20.77079  4.68139   19.87952  1.000 53.67697 ? 632 ASP A C   1 
ATOM   2133 O O   . ASP A 1 280 ? 21.61601  5.57768   19.99428  1.000 50.47521 ? 632 ASP A O   1 
ATOM   2134 C CB  . ASP A 1 280 ? 20.53127  3.72647   17.57780  1.000 55.32523 ? 632 ASP A CB  1 
ATOM   2135 C CG  . ASP A 1 280 ? 21.35021  3.02695   16.51401  1.000 60.35586 ? 632 ASP A CG  1 
ATOM   2136 O OD1 . ASP A 1 280 ? 22.58718  2.94621   16.67179  1.000 74.57805 ? 632 ASP A OD1 1 
ATOM   2137 O OD2 . ASP A 1 280 ? 20.75673  2.56835   15.51220  1.000 54.94613 ? 632 ASP A OD2 1 
ATOM   2138 N N   . VAL A 1 281 ? 19.58994  4.75011   20.48606  1.000 45.53608 ? 633 VAL A N   1 
ATOM   2139 C CA  . VAL A 1 281 ? 19.22714  5.92320   21.28487  1.000 50.04466 ? 633 VAL A CA  1 
ATOM   2140 C C   . VAL A 1 281 ? 20.00416  5.95810   22.60048  1.000 45.96449 ? 633 VAL A C   1 
ATOM   2141 O O   . VAL A 1 281 ? 19.89086  5.04335   23.41262  1.000 49.91083 ? 633 VAL A O   1 
ATOM   2142 C CB  . VAL A 1 281 ? 17.70832  5.96676   21.55557  1.000 50.59828 ? 633 VAL A CB  1 
ATOM   2143 C CG1 . VAL A 1 281 ? 17.38911  6.99690   22.62992  1.000 53.14377 ? 633 VAL A CG1 1 
ATOM   2144 C CG2 . VAL A 1 281 ? 16.94986  6.27936   20.27398  1.000 52.81830 ? 633 VAL A CG2 1 
ATOM   2145 N N   . LEU B 1 13  ? 11.85393  19.32081  -4.30088  1.000 39.76121 ? 365 LEU B N   1 
ATOM   2146 C CA  . LEU B 1 13  ? 11.44400  18.74570  -3.02138  1.000 38.43269 ? 365 LEU B CA  1 
ATOM   2147 C C   . LEU B 1 13  ? 12.56598  18.75710  -1.97806  1.000 41.10497 ? 365 LEU B C   1 
ATOM   2148 O O   . LEU B 1 13  ? 13.75231  18.81950  -2.30301  1.000 49.09921 ? 365 LEU B O   1 
ATOM   2149 C CB  . LEU B 1 13  ? 10.94643  17.31195  -3.21295  1.000 40.51975 ? 365 LEU B CB  1 
ATOM   2150 C CG  . LEU B 1 13  ? 9.69933   17.13471  -4.07950  1.000 46.35374 ? 365 LEU B CG  1 
ATOM   2151 C CD1 . LEU B 1 13  ? 9.19489   15.70135  -4.02719  1.000 36.87343 ? 365 LEU B CD1 1 
ATOM   2152 C CD2 . LEU B 1 13  ? 8.61852   18.09869  -3.63262  1.000 36.96490 ? 365 LEU B CD2 1 
ATOM   2153 N N   . ASP B 1 14  ? 12.17152  18.67534  -0.71642  1.000 38.79379 ? 366 ASP B N   1 
ATOM   2154 C CA  . ASP B 1 14  ? 13.10401  18.64102  0.40128   1.000 43.37484 ? 366 ASP B CA  1 
ATOM   2155 C C   . ASP B 1 14  ? 13.41113  17.18774  0.75326   1.000 41.59034 ? 366 ASP B C   1 
ATOM   2156 O O   . ASP B 1 14  ? 12.52756  16.46145  1.22381   1.000 38.44231 ? 366 ASP B O   1 
ATOM   2157 C CB  . ASP B 1 14  ? 12.49080  19.37899  1.59277   1.000 48.94232 ? 366 ASP B CB  1 
ATOM   2158 C CG  . ASP B 1 14  ? 13.46974  19.59551  2.73027   1.000 50.71885 ? 366 ASP B CG  1 
ATOM   2159 O OD1 . ASP B 1 14  ? 14.56251  18.99302  2.73009   1.000 51.34395 ? 366 ASP B OD1 1 
ATOM   2160 O OD2 . ASP B 1 14  ? 13.13320  20.39006  3.62888   1.000 54.85107 ? 366 ASP B OD2 1 
ATOM   2161 N N   . ARG B 1 15  ? 14.66273  16.76648  0.53944   1.000 31.54074 ? 367 ARG B N   1 
ATOM   2162 C CA  . ARG B 1 15  ? 15.05838  15.40166  0.89234   1.000 39.43158 ? 367 ARG B CA  1 
ATOM   2163 C C   . ARG B 1 15  ? 14.77037  15.07328  2.35830   1.000 39.12168 ? 367 ARG B C   1 
ATOM   2164 O O   . ARG B 1 15  ? 14.56440  13.89964  2.69020   1.000 42.07023 ? 367 ARG B O   1 
ATOM   2165 C CB  . ARG B 1 15  ? 16.55050  15.18553  0.58413   1.000 37.00172 ? 367 ARG B CB  1 
ATOM   2166 C CG  . ARG B 1 15  ? 17.07092  13.76387  0.88027   1.000 35.82141 ? 367 ARG B CG  1 
ATOM   2167 C CD  . ARG B 1 15  ? 16.46158  12.76451  -0.06520  1.000 34.33560 ? 367 ARG B CD  1 
ATOM   2168 N NE  . ARG B 1 15  ? 17.05812  11.44346  0.08731   1.000 40.05614 ? 367 ARG B NE  1 
ATOM   2169 C CZ  . ARG B 1 15  ? 16.56633  10.49632  0.87113   1.000 40.18297 ? 367 ARG B CZ  1 
ATOM   2170 N NH1 . ARG B 1 15  ? 15.46924  10.69412  1.58415   1.000 42.96852 ? 367 ARG B NH1 1 
ATOM   2171 N NH2 . ARG B 1 15  ? 17.17700  9.31433   0.92438   1.000 42.39376 ? 367 ARG B NH2 1 
ATOM   2172 N N   . LYS B 1 16  ? 14.72011  16.07842  3.24040   1.000 40.67396 ? 368 LYS B N   1 
ATOM   2173 C CA  . LYS B 1 16  ? 14.40949  15.81043  4.64336   1.000 48.88498 ? 368 LYS B CA  1 
ATOM   2174 C C   . LYS B 1 16  ? 12.96976  15.34134  4.84084   1.000 41.48710 ? 368 LYS B C   1 
ATOM   2175 O O   . LYS B 1 16  ? 12.66791  14.69474  5.85089   1.000 44.76004 ? 368 LYS B O   1 
ATOM   2176 C CB  . LYS B 1 16  ? 14.66741  17.05695  5.49326   1.000 48.80628 ? 368 LYS B CB  1 
ATOM   2177 C CG  . LYS B 1 16  ? 16.14259  17.37495  5.71180   1.000 49.63558 ? 368 LYS B CG  1 
ATOM   2178 C CD  . LYS B 1 16  ? 16.35526  18.34588  6.87994   1.000 49.33256 ? 368 LYS B CD  1 
ATOM   2179 C CE  . LYS B 1 16  ? 16.18805  19.80550  6.46617   1.000 60.03012 ? 368 LYS B CE  1 
ATOM   2180 N NZ  . LYS B 1 16  ? 14.76301  20.20913  6.29513   1.000 66.31738 ? 368 LYS B NZ  1 
ATOM   2181 N N   . LEU B 1 17  ? 12.08151  15.65655  3.90842   1.000 38.87969 ? 369 LEU B N   1 
ATOM   2182 C CA  . LEU B 1 17  ? 10.68063  15.27635  3.99873   1.000 42.27659 ? 369 LEU B CA  1 
ATOM   2183 C C   . LEU B 1 17  ? 10.37846  13.98902  3.24589   1.000 40.34592 ? 369 LEU B C   1 
ATOM   2184 O O   . LEU B 1 17  ? 9.21158   13.57643  3.18866   1.000 41.01658 ? 369 LEU B O   1 
ATOM   2185 C CB  . LEU B 1 17  ? 9.79677   16.41134  3.47274   1.000 42.09678 ? 369 LEU B CB  1 
ATOM   2186 C CG  . LEU B 1 17  ? 9.95909   17.74304  4.21729   1.000 53.03321 ? 369 LEU B CG  1 
ATOM   2187 C CD1 . LEU B 1 17  ? 8.93304   18.78367  3.76147   1.000 42.52031 ? 369 LEU B CD1 1 
ATOM   2188 C CD2 . LEU B 1 17  ? 9.87784   17.51249  5.72284   1.000 47.57320 ? 369 LEU B CD2 1 
ATOM   2189 N N   . LEU B 1 18  ? 11.39552  13.34580  2.67734   1.000 39.26349 ? 370 LEU B N   1 
ATOM   2190 C CA  . LEU B 1 18  ? 11.23521  12.10908  1.92928   1.000 35.26273 ? 370 LEU B CA  1 
ATOM   2191 C C   . LEU B 1 18  ? 11.88206  10.96833  2.69466   1.000 35.94923 ? 370 LEU B C   1 
ATOM   2192 O O   . LEU B 1 18  ? 13.04969  11.06143  3.08663   1.000 37.53159 ? 370 LEU B O   1 
ATOM   2193 C CB  . LEU B 1 18  ? 11.86498  12.22705  0.53763   1.000 31.46897 ? 370 LEU B CB  1 
ATOM   2194 C CG  . LEU B 1 18  ? 11.85550  10.94557  -0.30773  1.000 32.29584 ? 370 LEU B CG  1 
ATOM   2195 C CD1 . LEU B 1 18  ? 10.40329  10.54054  -0.67750  1.000 28.35518 ? 370 LEU B CD1 1 
ATOM   2196 C CD2 . LEU B 1 18  ? 12.70320  11.13566  -1.57212  1.000 32.95081 ? 370 LEU B CD2 1 
ATOM   2197 N N   . THR B 1 19  ? 11.13356  9.89451   2.90666   1.000 30.95270 ? 371 THR B N   1 
ATOM   2198 C CA  . THR B 1 19  ? 11.69469  8.65744   3.42420   1.000 29.18211 ? 371 THR B CA  1 
ATOM   2199 C C   . THR B 1 19  ? 11.61616  7.60511   2.33664   1.000 36.17306 ? 371 THR B C   1 
ATOM   2200 O O   . THR B 1 19  ? 10.55806  7.42469   1.72305   1.000 35.48771 ? 371 THR B O   1 
ATOM   2201 C CB  . THR B 1 19  ? 10.96447  8.16059   4.67330   1.000 36.82489 ? 371 THR B CB  1 
ATOM   2202 O OG1 . THR B 1 19  ? 11.17567  9.07107   5.75285   1.000 43.27713 ? 371 THR B OG1 1 
ATOM   2203 C CG2 . THR B 1 19  ? 11.49013  6.77970   5.07376   1.000 30.61960 ? 371 THR B CG2 1 
ATOM   2204 N N   . LEU B 1 20  ? 12.73013  6.91772   2.09815   1.000 34.05770 ? 372 LEU B N   1 
ATOM   2205 C CA  . LEU B 1 20  ? 12.79751  5.85359   1.10833   1.000 32.03824 ? 372 LEU B CA  1 
ATOM   2206 C C   . LEU B 1 20  ? 12.95882  4.49587   1.78413   1.000 35.26359 ? 372 LEU B C   1 
ATOM   2207 O O   . LEU B 1 20  ? 13.74198  4.35088   2.72439   1.000 35.87992 ? 372 LEU B O   1 
ATOM   2208 C CB  . LEU B 1 20  ? 13.95718  6.08647   0.14139   1.000 33.69209 ? 372 LEU B CB  1 
ATOM   2209 C CG  . LEU B 1 20  ? 13.81561  7.24125   -0.84835  1.000 31.88327 ? 372 LEU B CG  1 
ATOM   2210 C CD1 . LEU B 1 20  ? 15.13225  7.42378   -1.58339  1.000 36.16997 ? 372 LEU B CD1 1 
ATOM   2211 C CD2 . LEU B 1 20  ? 12.68142  6.96355   -1.82761  1.000 29.35329 ? 372 LEU B CD2 1 
ATOM   2212 N N   . GLU B 1 21  ? 12.21066  3.50445   1.30217   1.000 36.26957 ? 373 GLU B N   1 
ATOM   2213 C CA  . GLU B 1 21  ? 12.39038  2.12413   1.74160   1.000 42.63332 ? 373 GLU B CA  1 
ATOM   2214 C C   . GLU B 1 21  ? 13.59640  1.50910   1.04577   1.000 42.56517 ? 373 GLU B C   1 
ATOM   2215 O O   . GLU B 1 21  ? 13.79824  1.69946   -0.15593  1.000 38.26305 ? 373 GLU B O   1 
ATOM   2216 C CB  . GLU B 1 21  ? 11.14466  1.28945   1.44311   1.000 34.57963 ? 373 GLU B CB  1 
ATOM   2217 C CG  . GLU B 1 21  ? 9.95243   1.60882   2.35149   1.000 42.42501 ? 373 GLU B CG  1 
ATOM   2218 C CD  . GLU B 1 21  ? 10.15102  1.10415   3.77472   1.000 49.52648 ? 373 GLU B CD  1 
ATOM   2219 O OE1 . GLU B 1 21  ? 10.96800  0.17207   3.95793   1.000 52.19680 ? 373 GLU B OE1 1 
ATOM   2220 O OE2 . GLU B 1 21  ? 9.49318   1.63743   4.70819   1.000 39.43256 ? 373 GLU B OE2 1 
ATOM   2221 N N   . ASP B 1 22  ? 14.39138  0.75330   1.80546   1.000 39.59393 ? 374 ASP B N   1 
ATOM   2222 C CA  . ASP B 1 22  ? 15.63871  0.21538   1.26395   1.000 51.36381 ? 374 ASP B CA  1 
ATOM   2223 C C   . ASP B 1 22  ? 15.38558  -0.70150  0.06986   1.000 50.25232 ? 374 ASP B C   1 
ATOM   2224 O O   . ASP B 1 22  ? 15.95353  -0.50132  -1.01262  1.000 52.22399 ? 374 ASP B O   1 
ATOM   2225 C CB  . ASP B 1 22  ? 16.40172  -0.53005  2.35795   1.000 50.53682 ? 374 ASP B CB  1 
ATOM   2226 C CG  . ASP B 1 22  ? 17.01353  0.40187   3.37338   1.000 56.26002 ? 374 ASP B CG  1 
ATOM   2227 O OD1 . ASP B 1 22  ? 17.35221  1.54730   3.00439   1.000 60.45553 ? 374 ASP B OD1 1 
ATOM   2228 O OD2 . ASP B 1 22  ? 17.15921  -0.01594  4.54099   1.000 74.99698 ? 374 ASP B OD2 1 
ATOM   2229 N N   . LYS B 1 23  ? 14.53216  -1.71082  0.25037   1.000 40.41540 ? 375 LYS B N   1 
ATOM   2230 C CA  . LYS B 1 23  ? 14.26340  -2.71224  -0.78268  1.000 49.24665 ? 375 LYS B CA  1 
ATOM   2231 C C   . LYS B 1 23  ? 13.56315  -2.05814  -1.96860  1.000 44.16797 ? 375 LYS B C   1 
ATOM   2232 O O   . LYS B 1 23  ? 12.41625  -1.61504  -1.85366  1.000 49.47514 ? 375 LYS B O   1 
ATOM   2233 C CB  . LYS B 1 23  ? 13.40448  -3.83575  -0.20835  1.000 47.78059 ? 375 LYS B CB  1 
ATOM   2234 C CG  . LYS B 1 23  ? 13.04670  -4.92785  -1.21299  1.000 53.31836 ? 375 LYS B CG  1 
ATOM   2235 C CD  . LYS B 1 23  ? 11.70703  -5.56903  -0.86613  1.000 60.58236 ? 375 LYS B CD  1 
ATOM   2236 C CE  . LYS B 1 23  ? 11.72528  -7.07963  -1.06005  1.000 50.41010 ? 375 LYS B CE  1 
ATOM   2237 N NZ  . LYS B 1 23  ? 12.07027  -7.46140  -2.45549  1.000 59.00704 ? 375 LYS B NZ  1 
ATOM   2238 N N   . GLU B 1 24  ? 14.23705  -2.01432  -3.11202  1.000 39.53607 ? 376 GLU B N   1 
ATOM   2239 C CA  . GLU B 1 24  ? 13.67268  -1.37694  -4.28768  1.000 40.36651 ? 376 GLU B CA  1 
ATOM   2240 C C   . GLU B 1 24  ? 12.40445  -2.10226  -4.73279  1.000 34.66204 ? 376 GLU B C   1 
ATOM   2241 O O   . GLU B 1 24  ? 12.19478  -3.28093  -4.44781  1.000 44.01269 ? 376 GLU B O   1 
ATOM   2242 C CB  . GLU B 1 24  ? 14.69052  -1.37855  -5.42569  1.000 34.39091 ? 376 GLU B CB  1 
ATOM   2243 C CG  . GLU B 1 24  ? 14.79310  -2.74969  -6.09401  1.000 51.13103 ? 376 GLU B CG  1 
ATOM   2244 C CD  . GLU B 1 24  ? 15.97012  -2.87548  -7.03264  1.000 61.49335 ? 376 GLU B CD  1 
ATOM   2245 O OE1 . GLU B 1 24  ? 16.86088  -2.00353  -6.96731  1.000 52.41644 ? 376 GLU B OE1 1 
ATOM   2246 O OE2 . GLU B 1 24  ? 16.00049  -3.84805  -7.82763  1.000 66.95190 ? 376 GLU B OE2 1 
ATOM   2247 N N   . LEU B 1 25  ? 11.55182  -1.38125  -5.45250  1.000 32.78244 ? 377 LEU B N   1 
ATOM   2248 C CA  . LEU B 1 25  ? 10.42363  -2.02938  -6.10421  1.000 31.15119 ? 377 LEU B CA  1 
ATOM   2249 C C   . LEU B 1 25  ? 10.84728  -2.73816  -7.37982  1.000 39.87272 ? 377 LEU B C   1 
ATOM   2250 O O   . LEU B 1 25  ? 10.16736  -3.67242  -7.82003  1.000 37.01735 ? 377 LEU B O   1 
ATOM   2251 C CB  . LEU B 1 25  ? 9.33517   -1.00353  -6.41867  1.000 37.10880 ? 377 LEU B CB  1 
ATOM   2252 C CG  . LEU B 1 25  ? 8.61763   -0.43071  -5.19783  1.000 41.11718 ? 377 LEU B CG  1 
ATOM   2253 C CD1 . LEU B 1 25  ? 7.85170   0.82420   -5.57324  1.000 31.29463 ? 377 LEU B CD1 1 
ATOM   2254 C CD2 . LEU B 1 25  ? 7.68088   -1.47327  -4.56452  1.000 34.21211 ? 377 LEU B CD2 1 
ATOM   2255 N N   . GLY B 1 26  ? 11.96183  -2.31661  -7.95877  1.000 36.12281 ? 378 GLY B N   1 
ATOM   2256 C CA  . GLY B 1 26  ? 12.44008  -2.85104  -9.21302  1.000 41.83570 ? 378 GLY B CA  1 
ATOM   2257 C C   . GLY B 1 26  ? 13.54544  -1.96164  -9.73352  1.000 42.80158 ? 378 GLY B C   1 
ATOM   2258 O O   . GLY B 1 26  ? 13.88682  -0.93246  -9.13458  1.000 35.65787 ? 378 GLY B O   1 
ATOM   2259 N N   . SER B 1 27  ? 14.09639  -2.36920  -10.87159 1.000 40.82650 ? 379 SER B N   1 
ATOM   2260 C CA  . SER B 1 27  ? 15.16610  -1.61334  -11.49970 1.000 43.23324 ? 379 SER B CA  1 
ATOM   2261 C C   . SER B 1 27  ? 14.95989  -1.58719  -13.00924 1.000 49.37840 ? 379 SER B C   1 
ATOM   2262 O O   . SER B 1 27  ? 14.14398  -2.33121  -13.57130 1.000 47.41943 ? 379 SER B O   1 
ATOM   2263 C CB  . SER B 1 27  ? 16.53858  -2.20193  -11.14202 1.000 48.09296 ? 379 SER B CB  1 
ATOM   2264 O OG  . SER B 1 27  ? 16.58827  -3.57955  -11.47907 1.000 49.49259 ? 379 SER B OG  1 
ATOM   2265 N N   . GLY B 1 28  ? 15.71554  -0.70550  -13.66014 1.000 43.62183 ? 380 GLY B N   1 
ATOM   2266 C CA  . GLY B 1 28  ? 15.74149  -0.60571  -15.10504 1.000 43.90410 ? 380 GLY B CA  1 
ATOM   2267 C C   . GLY B 1 28  ? 17.09787  -0.13690  -15.59500 1.000 38.25490 ? 380 GLY B C   1 
ATOM   2268 O O   . GLY B 1 28  ? 18.06666  -0.13155  -14.82902 1.000 39.81733 ? 380 GLY B O   1 
ATOM   2269 N N   . ASN B 1 29  ? 17.18590  0.25708   -16.86741 1.000 45.75931 ? 381 ASN B N   1 
ATOM   2270 C CA  . ASN B 1 29  ? 18.44044  0.78879   -17.39535 1.000 44.14670 ? 381 ASN B CA  1 
ATOM   2271 C C   . ASN B 1 29  ? 18.85120  2.07135   -16.67971 1.000 47.83067 ? 381 ASN B C   1 
ATOM   2272 O O   . ASN B 1 29  ? 20.04743  2.37851   -16.57789 1.000 45.92960 ? 381 ASN B O   1 
ATOM   2273 C CB  . ASN B 1 29  ? 18.29669  1.05358   -18.89212 1.000 53.12800 ? 381 ASN B CB  1 
ATOM   2274 C CG  . ASN B 1 29  ? 17.30725  2.16073   -19.18466 1.000 49.17160 ? 381 ASN B CG  1 
ATOM   2275 O OD1 . ASN B 1 29  ? 17.67036  3.33473   -19.22430 1.000 53.39661 ? 381 ASN B OD1 1 
ATOM   2276 N ND2 . ASN B 1 29  ? 16.04363  1.79376   -19.37388 1.000 59.88952 ? 381 ASN B ND2 1 
ATOM   2277 N N   . PHE B 1 30  ? 17.87622  2.82408   -16.17142 1.000 38.05714 ? 382 PHE B N   1 
ATOM   2278 C CA  . PHE B 1 30  ? 18.12199  4.12477   -15.55682 1.000 37.87022 ? 382 PHE B CA  1 
ATOM   2279 C C   . PHE B 1 30  ? 18.59598  4.03406   -14.10956 1.000 37.05907 ? 382 PHE B C   1 
ATOM   2280 O O   . PHE B 1 30  ? 19.11158  5.01876   -13.57535 1.000 39.47870 ? 382 PHE B O   1 
ATOM   2281 C CB  . PHE B 1 30  ? 16.83454  4.94219   -15.59144 1.000 38.99846 ? 382 PHE B CB  1 
ATOM   2282 C CG  . PHE B 1 30  ? 15.66507  4.18584   -15.07486 1.000 36.13480 ? 382 PHE B CG  1 
ATOM   2283 C CD1 . PHE B 1 30  ? 15.45878  4.05519   -13.70624 1.000 40.38236 ? 382 PHE B CD1 1 
ATOM   2284 C CD2 . PHE B 1 30  ? 14.79516  3.55232   -15.95337 1.000 39.19290 ? 382 PHE B CD2 1 
ATOM   2285 C CE1 . PHE B 1 30  ? 14.38489  3.31447   -13.21911 1.000 36.28099 ? 382 PHE B CE1 1 
ATOM   2286 C CE2 . PHE B 1 30  ? 13.72656  2.81557   -15.48138 1.000 39.37513 ? 382 PHE B CE2 1 
ATOM   2287 C CZ  . PHE B 1 30  ? 13.51887  2.69750   -14.10984 1.000 40.33001 ? 382 PHE B CZ  1 
ATOM   2288 N N   . GLY B 1 31  ? 18.40514  2.90116   -13.45329 1.000 38.65478 ? 383 GLY B N   1 
ATOM   2289 C CA  . GLY B 1 31  ? 18.57187  2.85033   -12.01647 1.000 31.50927 ? 383 GLY B CA  1 
ATOM   2290 C C   . GLY B 1 31  ? 17.43676  2.08912   -11.36258 1.000 43.79303 ? 383 GLY B C   1 
ATOM   2291 O O   . GLY B 1 31  ? 17.06906  1.00552   -11.82789 1.000 39.31974 ? 383 GLY B O   1 
ATOM   2292 N N   . THR B 1 32  ? 16.85285  2.64048   -10.29858 1.000 40.24337 ? 384 THR B N   1 
ATOM   2293 C CA  . THR B 1 32  ? 15.90787  1.88134   -9.49480  1.000 38.68800 ? 384 THR B CA  1 
ATOM   2294 C C   . THR B 1 32  ? 14.62073  2.65819   -9.26337  1.000 31.55563 ? 384 THR B C   1 
ATOM   2295 O O   . THR B 1 32  ? 14.54626  3.87770   -9.44243  1.000 30.96814 ? 384 THR B O   1 
ATOM   2296 C CB  . THR B 1 32  ? 16.50537  1.48890   -8.12899  1.000 36.71541 ? 384 THR B CB  1 
ATOM   2297 O OG1 . THR B 1 32  ? 16.77025  2.67683   -7.37549  1.000 37.09991 ? 384 THR B OG1 1 
ATOM   2298 C CG2 . THR B 1 32  ? 17.79859  0.68846   -8.31396  1.000 37.51992 ? 384 THR B CG2 1 
ATOM   2299 N N   . VAL B 1 33  ? 13.60431  1.91755   -8.83798  1.000 33.90085 ? 385 VAL B N   1 
ATOM   2300 C CA  . VAL B 1 33  ? 12.34881  2.48808   -8.36555  1.000 29.20944 ? 385 VAL B CA  1 
ATOM   2301 C C   . VAL B 1 33  ? 12.14311  2.03444   -6.92678  1.000 28.25162 ? 385 VAL B C   1 
ATOM   2302 O O   . VAL B 1 33  ? 12.18930  0.83116   -6.63961  1.000 28.71301 ? 385 VAL B O   1 
ATOM   2303 C CB  . VAL B 1 33  ? 11.16520  2.05724   -9.24846  1.000 28.99800 ? 385 VAL B CB  1 
ATOM   2304 C CG1 . VAL B 1 33  ? 9.87986   2.64658   -8.70182  1.000 29.26184 ? 385 VAL B CG1 1 
ATOM   2305 C CG2 . VAL B 1 33  ? 11.38469  2.49500   -10.70727 1.000 31.10427 ? 385 VAL B CG2 1 
ATOM   2306 N N   . LYS B 1 34  ? 11.91992  2.99007   -6.02634  1.000 31.96619 ? 386 LYS B N   1 
ATOM   2307 C CA  . LYS B 1 34  ? 11.72343  2.68943   -4.61748  1.000 28.94645 ? 386 LYS B CA  1 
ATOM   2308 C C   . LYS B 1 34  ? 10.39687  3.24935   -4.13712  1.000 33.48151 ? 386 LYS B C   1 
ATOM   2309 O O   . LYS B 1 34  ? 9.89881   4.26183   -4.64456  1.000 27.92474 ? 386 LYS B O   1 
ATOM   2310 C CB  . LYS B 1 34  ? 12.83783  3.25957   -3.73577  1.000 35.11317 ? 386 LYS B CB  1 
ATOM   2311 C CG  . LYS B 1 34  ? 14.20449  2.66323   -3.97447  1.000 41.21292 ? 386 LYS B CG  1 
ATOM   2312 C CD  . LYS B 1 34  ? 15.18318  3.20906   -2.94448  1.000 48.82812 ? 386 LYS B CD  1 
ATOM   2313 C CE  . LYS B 1 34  ? 16.62724  2.95463   -3.33800  1.000 60.56468 ? 386 LYS B CE  1 
ATOM   2314 N NZ  . LYS B 1 34  ? 17.53489  3.97616   -2.71020  1.000 70.20894 ? 386 LYS B NZ  1 
ATOM   2315 N N   . LYS B 1 35  ? 9.83133   2.57067   -3.15491  1.000 29.00159 ? 387 LYS B N   1 
ATOM   2316 C CA  . LYS B 1 35  ? 8.67062   3.09370   -2.45772  1.000 30.05380 ? 387 LYS B CA  1 
ATOM   2317 C C   . LYS B 1 35  ? 9.13616   4.09829   -1.42558  1.000 34.79219 ? 387 LYS B C   1 
ATOM   2318 O O   . LYS B 1 35  ? 10.21531  3.94707   -0.83645  1.000 36.26840 ? 387 LYS B O   1 
ATOM   2319 C CB  . LYS B 1 35  ? 7.89715   1.96853   -1.77823  1.000 32.44082 ? 387 LYS B CB  1 
ATOM   2320 C CG  . LYS B 1 35  ? 6.64735   2.42423   -1.05231  1.000 34.97236 ? 387 LYS B CG  1 
ATOM   2321 C CD  . LYS B 1 35  ? 5.90557   1.21611   -0.54945  1.000 41.96703 ? 387 LYS B CD  1 
ATOM   2322 C CE  . LYS B 1 35  ? 4.57593   1.57531   0.03469   1.000 35.63885 ? 387 LYS B CE  1 
ATOM   2323 N NZ  . LYS B 1 35  ? 3.84874   0.30902   0.34876   1.000 37.73755 ? 387 LYS B NZ  1 
ATOM   2324 N N   . GLY B 1 36  ? 8.32441   5.13267   -1.20824  1.000 29.88527 ? 388 GLY B N   1 
ATOM   2325 C CA  . GLY B 1 36  ? 8.67852   6.12646   -0.22293  1.000 26.20665 ? 388 GLY B CA  1 
ATOM   2326 C C   . GLY B 1 36  ? 7.45091   6.79486   0.35734   1.000 33.92202 ? 388 GLY B C   1 
ATOM   2327 O O   . GLY B 1 36  ? 6.30920   6.50231   -0.01150  1.000 28.03432 ? 388 GLY B O   1 
ATOM   2328 N N   . TYR B 1 37  ? 7.71048   7.71139   1.28032   1.000 32.59257 ? 389 TYR B N   1 
ATOM   2329 C CA  . TYR B 1 37  ? 6.67127   8.45705   1.97180   1.000 27.20757 ? 389 TYR B CA  1 
ATOM   2330 C C   . TYR B 1 37  ? 7.11729   9.90759   1.97535   1.000 32.29499 ? 389 TYR B C   1 
ATOM   2331 O O   . TYR B 1 37  ? 8.25015   10.19913  2.37608   1.000 40.38825 ? 389 TYR B O   1 
ATOM   2332 C CB  . TYR B 1 37  ? 6.46711   7.92381   3.40324   1.000 30.11712 ? 389 TYR B CB  1 
ATOM   2333 C CG  . TYR B 1 37  ? 6.60610   6.40190   3.50823   1.000 32.76287 ? 389 TYR B CG  1 
ATOM   2334 C CD1 . TYR B 1 37  ? 5.58461   5.54851   3.07971   1.000 26.41825 ? 389 TYR B CD1 1 
ATOM   2335 C CD2 . TYR B 1 37  ? 7.76878   5.82485   4.00537   1.000 33.57363 ? 389 TYR B CD2 1 
ATOM   2336 C CE1 . TYR B 1 37  ? 5.72081   4.15399   3.15685   1.000 29.06185 ? 389 TYR B CE1 1 
ATOM   2337 C CE2 . TYR B 1 37  ? 7.90827   4.43988   4.08931   1.000 38.39529 ? 389 TYR B CE2 1 
ATOM   2338 C CZ  . TYR B 1 37  ? 6.87681   3.60854   3.66931   1.000 35.29748 ? 389 TYR B CZ  1 
ATOM   2339 O OH  . TYR B 1 37  ? 7.02465   2.22672   3.74980   1.000 32.88738 ? 389 TYR B OH  1 
ATOM   2340 N N   . TYR B 1 38  ? 6.26086   10.80755  1.49294   1.000 27.07070 ? 390 TYR B N   1 
ATOM   2341 C CA  . TYR B 1 38  ? 6.58465   12.22844  1.41787   1.000 29.37680 ? 390 TYR B CA  1 
ATOM   2342 C C   . TYR B 1 38  ? 5.62053   13.04058  2.27525   1.000 35.64490 ? 390 TYR B C   1 
ATOM   2343 O O   . TYR B 1 38  ? 4.40120   12.93744  2.12060   1.000 31.52081 ? 390 TYR B O   1 
ATOM   2344 C CB  . TYR B 1 38  ? 6.55196   12.73652  -0.02821  1.000 37.38026 ? 390 TYR B CB  1 
ATOM   2345 C CG  . TYR B 1 38  ? 7.19727   14.09012  -0.14406  1.000 35.73811 ? 390 TYR B CG  1 
ATOM   2346 C CD1 . TYR B 1 38  ? 8.57474   14.22551  0.02037   1.000 41.13258 ? 390 TYR B CD1 1 
ATOM   2347 C CD2 . TYR B 1 38  ? 6.43990   15.23941  -0.37042  1.000 37.04004 ? 390 TYR B CD2 1 
ATOM   2348 C CE1 . TYR B 1 38  ? 9.18748   15.46332  -0.05383  1.000 44.35832 ? 390 TYR B CE1 1 
ATOM   2349 C CE2 . TYR B 1 38  ? 7.04532   16.49007  -0.44601  1.000 40.05863 ? 390 TYR B CE2 1 
ATOM   2350 C CZ  . TYR B 1 38  ? 8.42353   16.58996  -0.28789  1.000 41.16518 ? 390 TYR B CZ  1 
ATOM   2351 O OH  . TYR B 1 38  ? 9.05880   17.80953  -0.36100  1.000 46.94508 ? 390 TYR B OH  1 
ATOM   2352 N N   . GLN B 1 39  ? 6.16882   13.84745  3.17376   1.000 40.95534 ? 391 GLN B N   1 
ATOM   2353 C CA  . GLN B 1 39  ? 5.34393   14.69080  4.03477   1.000 43.63726 ? 391 GLN B CA  1 
ATOM   2354 C C   . GLN B 1 39  ? 4.75498   15.84125  3.22487   1.000 49.13305 ? 391 GLN B C   1 
ATOM   2355 O O   . GLN B 1 39  ? 5.49486   16.65567  2.66604   1.000 42.04881 ? 391 GLN B O   1 
ATOM   2356 C CB  . GLN B 1 39  ? 6.17563   15.21960  5.20292   1.000 54.24985 ? 391 GLN B CB  1 
ATOM   2357 C CG  . GLN B 1 39  ? 5.45120   16.20718  6.12863   1.000 48.81203 ? 391 GLN B CG  1 
ATOM   2358 C CD  . GLN B 1 39  ? 4.43263   15.54663  7.04401   1.000 45.53200 ? 391 GLN B CD  1 
ATOM   2359 O OE1 . GLN B 1 39  ? 4.78100   14.96941  8.08657   1.000 60.49050 ? 391 GLN B OE1 1 
ATOM   2360 N NE2 . GLN B 1 39  ? 3.15881   15.63576  6.66520   1.000 50.67569 ? 391 GLN B NE2 1 
ATOM   2361 N N   . MET B 1 40  ? 3.42374   15.90659  3.16680   1.000 47.46985 ? 392 MET B N   1 
ATOM   2362 C CA  . MET B 1 40  ? 2.68154   16.90091  2.40979   1.000 49.87381 ? 392 MET B CA  1 
ATOM   2363 C C   . MET B 1 40  ? 2.24337   18.03348  3.33827   1.000 55.57221 ? 392 MET B C   1 
ATOM   2364 O O   . MET B 1 40  ? 2.84179   18.24771  4.39983   1.000 47.41008 ? 392 MET B O   1 
ATOM   2365 C CB  . MET B 1 40  ? 1.48826   16.23299  1.71596   1.000 44.77328 ? 392 MET B CB  1 
ATOM   2366 C CG  . MET B 1 40  ? 1.88305   15.13088  0.73613   1.000 54.35921 ? 392 MET B CG  1 
ATOM   2367 S SD  . MET B 1 40  ? 2.43261   15.80347  -0.84120  1.000 50.46826 ? 392 MET B SD  1 
ATOM   2368 C CE  . MET B 1 40  ? 3.10848   14.37028  -1.66770  1.000 48.07156 ? 392 MET B CE  1 
ATOM   2369 N N   . LYS B 1 41  ? 1.18908   18.75916  2.94593   1.000 58.76918 ? 393 LYS B N   1 
ATOM   2370 C CA  . LYS B 1 41  ? 0.70320   19.87167  3.75763   1.000 62.90933 ? 393 LYS B CA  1 
ATOM   2371 C C   . LYS B 1 41  ? 0.47505   19.44042  5.20211   1.000 52.07718 ? 393 LYS B C   1 
ATOM   2372 O O   . LYS B 1 41  ? 0.91982   20.11341  6.13676   1.000 59.98499 ? 393 LYS B O   1 
ATOM   2373 C CB  . LYS B 1 41  ? -0.58138  20.44969  3.15289   1.000 68.21644 ? 393 LYS B CB  1 
ATOM   2374 C CG  . LYS B 1 41  ? -0.38450  21.15140  1.81491   1.000 68.75482 ? 393 LYS B CG  1 
ATOM   2375 C CD  . LYS B 1 41  ? -1.71151  21.51013  1.16586   1.000 69.89402 ? 393 LYS B CD  1 
ATOM   2376 C CE  . LYS B 1 41  ? -2.53376  22.43884  2.04607   1.000 69.82378 ? 393 LYS B CE  1 
ATOM   2377 N NZ  . LYS B 1 41  ? -3.60039  23.13240  1.26648   1.000 70.14556 ? 393 LYS B NZ  1 
ATOM   2378 N N   . LYS B 1 42  ? -0.19082  18.30060  5.40501   1.000 54.63051 ? 394 LYS B N   1 
ATOM   2379 C CA  . LYS B 1 42  ? -0.41530  17.79247  6.75611   1.000 41.74513 ? 394 LYS B CA  1 
ATOM   2380 C C   . LYS B 1 42  ? -0.22466  16.28338  6.83522   1.000 50.44789 ? 394 LYS B C   1 
ATOM   2381 O O   . LYS B 1 42  ? 0.41336   15.77522  7.76362   1.000 43.28064 ? 394 LYS B O   1 
ATOM   2382 C CB  . LYS B 1 42  ? -1.81565  18.15824  7.24469   1.000 52.12282 ? 394 LYS B CB  1 
ATOM   2383 C CG  . LYS B 1 42  ? -2.12874  17.61531  8.63736   1.000 47.60429 ? 394 LYS B CG  1 
ATOM   2384 C CD  . LYS B 1 42  ? -3.40618  18.20622  9.19976   1.000 46.17680 ? 394 LYS B CD  1 
ATOM   2385 C CE  . LYS B 1 42  ? -3.57459  17.83580  10.67815  1.000 43.88468 ? 394 LYS B CE  1 
ATOM   2386 N NZ  . LYS B 1 42  ? -4.83348  18.38594  11.25748  1.000 39.53875 ? 394 LYS B NZ  1 
ATOM   2387 N N   . VAL B 1 43  ? -0.79097  15.55363  5.87703   1.000 49.48589 ? 395 VAL B N   1 
ATOM   2388 C CA  . VAL B 1 43  ? -0.63989  14.10469  5.85490   1.000 37.25700 ? 395 VAL B CA  1 
ATOM   2389 C C   . VAL B 1 43  ? 0.67183   13.74663  5.17242   1.000 44.26875 ? 395 VAL B C   1 
ATOM   2390 O O   . VAL B 1 43  ? 1.37223   14.61011  4.62839   1.000 39.91965 ? 395 VAL B O   1 
ATOM   2391 C CB  . VAL B 1 43  ? -1.81920  13.41396  5.14840   1.000 36.15995 ? 395 VAL B CB  1 
ATOM   2392 C CG1 . VAL B 1 43  ? -3.14341  13.73343  5.85334   1.000 41.92821 ? 395 VAL B CG1 1 
ATOM   2393 C CG2 . VAL B 1 43  ? -1.85738  13.79412  3.68226   1.000 39.07067 ? 395 VAL B CG2 1 
ATOM   2394 N N   . VAL B 1 44  ? 1.01587   12.47446  5.20746   1.000 42.38464 ? 396 VAL B N   1 
ATOM   2395 C CA  . VAL B 1 44  ? 2.10220   11.94290  4.40060   1.000 42.22716 ? 396 VAL B CA  1 
ATOM   2396 C C   . VAL B 1 44  ? 1.49524   11.17554  3.23069   1.000 38.51724 ? 396 VAL B C   1 
ATOM   2397 O O   . VAL B 1 44  ? 0.39756   10.61058  3.33709   1.000 32.63151 ? 396 VAL B O   1 
ATOM   2398 C CB  . VAL B 1 44  ? 3.04511   11.09136  5.27281   1.000 37.85434 ? 396 VAL B CB  1 
ATOM   2399 C CG1 . VAL B 1 44  ? 3.94284   10.21359  4.44900   1.000 44.94081 ? 396 VAL B CG1 1 
ATOM   2400 C CG2 . VAL B 1 44  ? 3.90569   12.03545  6.11359   1.000 48.77373 ? 396 VAL B CG2 1 
ATOM   2401 N N   . LYS B 1 45  ? 2.16700   11.21835  2.08432   1.000 32.93049 ? 397 LYS B N   1 
ATOM   2402 C CA  . LYS B 1 45  ? 1.64023   10.65226  0.85344   1.000 26.94831 ? 397 LYS B CA  1 
ATOM   2403 C C   . LYS B 1 45  ? 2.58042   9.55424   0.38684   1.000 30.42098 ? 397 LYS B C   1 
ATOM   2404 O O   . LYS B 1 45  ? 3.80170   9.75407   0.35971   1.000 28.45293 ? 397 LYS B O   1 
ATOM   2405 C CB  . LYS B 1 45  ? 1.51078   11.73866  -0.21473  1.000 30.89415 ? 397 LYS B CB  1 
ATOM   2406 C CG  . LYS B 1 45  ? 1.05079   11.26743  -1.56868  1.000 34.76318 ? 397 LYS B CG  1 
ATOM   2407 C CD  . LYS B 1 45  ? -0.44371  11.16685  -1.59863  1.000 39.97897 ? 397 LYS B CD  1 
ATOM   2408 C CE  . LYS B 1 45  ? -0.97175  11.14955  -3.02603  1.000 37.69103 ? 397 LYS B CE  1 
ATOM   2409 N NZ  . LYS B 1 45  ? -2.33576  10.54921  -3.01140  1.000 34.69371 ? 397 LYS B NZ  1 
ATOM   2410 N N   . THR B 1 46  ? 2.02512   8.39840   0.03476   1.000 26.22249 ? 398 THR B N   1 
ATOM   2411 C CA  . THR B 1 46  ? 2.86911   7.32132   -0.46499  1.000 26.90389 ? 398 THR B CA  1 
ATOM   2412 C C   . THR B 1 46  ? 3.34062   7.63272   -1.88919  1.000 27.88774 ? 398 THR B C   1 
ATOM   2413 O O   . THR B 1 46  ? 2.53596   7.96866   -2.76826  1.000 26.32244 ? 398 THR B O   1 
ATOM   2414 C CB  . THR B 1 46  ? 2.12727   5.98405   -0.41324  1.000 28.16872 ? 398 THR B CB  1 
ATOM   2415 O OG1 . THR B 1 46  ? 1.68779   5.71624   0.93048   1.000 31.25490 ? 398 THR B OG1 1 
ATOM   2416 C CG2 . THR B 1 46  ? 3.06061   4.85271   -0.83244  1.000 31.46577 ? 398 THR B CG2 1 
ATOM   2417 N N   . VAL B 1 47  ? 4.65548   7.52041   -2.12182  1.000 25.94986 ? 399 VAL B N   1 
ATOM   2418 C CA  . VAL B 1 47  ? 5.23526   7.87694   -3.41046  1.000 23.81274 ? 399 VAL B CA  1 
ATOM   2419 C C   . VAL B 1 47  ? 6.04881   6.71188   -3.97343  1.000 31.72288 ? 399 VAL B C   1 
ATOM   2420 O O   . VAL B 1 47  ? 6.49877   5.81000   -3.26050  1.000 26.84795 ? 399 VAL B O   1 
ATOM   2421 C CB  . VAL B 1 47  ? 6.10842   9.14885   -3.33134  1.000 31.20312 ? 399 VAL B CB  1 
ATOM   2422 C CG1 . VAL B 1 47  ? 5.26086   10.34247  -2.96903  1.000 26.46699 ? 399 VAL B CG1 1 
ATOM   2423 C CG2 . VAL B 1 47  ? 7.24122   8.97305   -2.31263  1.000 29.06671 ? 399 VAL B CG2 1 
ATOM   2424 N N   . ALA B 1 48  ? 6.17951   6.72587   -5.29122  1.000 28.45775 ? 400 ALA B N   1 
ATOM   2425 C CA  . ALA B 1 48  ? 7.08332   5.86199   -6.02688  1.000 28.92328 ? 400 ALA B CA  1 
ATOM   2426 C C   . ALA B 1 48  ? 8.16152   6.76604   -6.60092  1.000 33.45141 ? 400 ALA B C   1 
ATOM   2427 O O   . ALA B 1 48  ? 7.85168   7.82653   -7.16416  1.000 32.23060 ? 400 ALA B O   1 
ATOM   2428 C CB  . ALA B 1 48  ? 6.35261   5.09807   -7.13111  1.000 25.80131 ? 400 ALA B CB  1 
ATOM   2429 N N   . VAL B 1 49  ? 9.41900   6.38716   -6.39877  1.000 28.83332 ? 401 VAL B N   1 
ATOM   2430 C CA  . VAL B 1 49  ? 10.54508  7.28287   -6.63669  1.000 31.09060 ? 401 VAL B CA  1 
ATOM   2431 C C   . VAL B 1 49  ? 11.47378  6.61657   -7.63695  1.000 27.12337 ? 401 VAL B C   1 
ATOM   2432 O O   . VAL B 1 49  ? 11.99503  5.52581   -7.38231  1.000 33.12176 ? 401 VAL B O   1 
ATOM   2433 C CB  . VAL B 1 49  ? 11.27446  7.64240   -5.32961  1.000 31.99705 ? 401 VAL B CB  1 
ATOM   2434 C CG1 . VAL B 1 49  ? 12.40076  8.64299   -5.59939  1.000 31.06965 ? 401 VAL B CG1 1 
ATOM   2435 C CG2 . VAL B 1 49  ? 10.29268  8.26118   -4.34358  1.000 29.78997 ? 401 VAL B CG2 1 
ATOM   2436 N N   . LYS B 1 50  ? 11.64014  7.25320   -8.78853  1.000 27.16462 ? 402 LYS B N   1 
ATOM   2437 C CA  . LYS B 1 50  ? 12.61675  6.83511   -9.78450  1.000 27.02068 ? 402 LYS B CA  1 
ATOM   2438 C C   . LYS B 1 50  ? 13.97245  7.43466   -9.42752  1.000 32.83379 ? 402 LYS B C   1 
ATOM   2439 O O   . LYS B 1 50  ? 14.10102  8.66009   -9.33173  1.000 34.33152 ? 402 LYS B O   1 
ATOM   2440 C CB  . LYS B 1 50  ? 12.15739  7.29163   -11.17093 1.000 26.67782 ? 402 LYS B CB  1 
ATOM   2441 C CG  . LYS B 1 50  ? 13.18324  7.11773   -12.28760 1.000 35.96605 ? 402 LYS B CG  1 
ATOM   2442 C CD  . LYS B 1 50  ? 12.59516  7.60646   -13.60628 1.000 35.14167 ? 402 LYS B CD  1 
ATOM   2443 C CE  . LYS B 1 50  ? 13.41806  7.14900   -14.80489 1.000 46.21691 ? 402 LYS B CE  1 
ATOM   2444 N NZ  . LYS B 1 50  ? 12.68925  7.39021   -16.09650 1.000 43.54716 ? 402 LYS B NZ  1 
ATOM   2445 N N   . ILE B 1 51  ? 14.98303  6.58116   -9.24319  1.000 32.43290 ? 403 ILE B N   1 
ATOM   2446 C CA  . ILE B 1 51  ? 16.28996  6.99797   -8.73852  1.000 34.70620 ? 403 ILE B CA  1 
ATOM   2447 C C   . ILE B 1 51  ? 17.36236  6.65382   -9.76588  1.000 32.60405 ? 403 ILE B C   1 
ATOM   2448 O O   . ILE B 1 51  ? 17.51132  5.48555   -10.15232 1.000 30.82270 ? 403 ILE B O   1 
ATOM   2449 C CB  . ILE B 1 51  ? 16.61153  6.33521   -7.39327  1.000 35.42001 ? 403 ILE B CB  1 
ATOM   2450 C CG1 . ILE B 1 51  ? 15.52512  6.66721   -6.36975  1.000 30.64780 ? 403 ILE B CG1 1 
ATOM   2451 C CG2 . ILE B 1 51  ? 17.99394  6.78816   -6.90083  1.000 29.94403 ? 403 ILE B CG2 1 
ATOM   2452 C CD1 . ILE B 1 51  ? 15.82707  6.10852   -5.00520  1.000 44.42622 ? 403 ILE B CD1 1 
ATOM   2453 N N   . LEU B 1 52  ? 18.12797  7.65576   -10.17828 1.000 34.38927 ? 404 LEU B N   1 
ATOM   2454 C CA  . LEU B 1 52  ? 19.15471  7.44339   -11.19422 1.000 36.05552 ? 404 LEU B CA  1 
ATOM   2455 C C   . LEU B 1 52  ? 20.37039  6.73694   -10.60502 1.000 32.38535 ? 404 LEU B C   1 
ATOM   2456 O O   . LEU B 1 52  ? 20.84721  7.09193   -9.52973  1.000 36.36098 ? 404 LEU B O   1 
ATOM   2457 C CB  . LEU B 1 52  ? 19.57463  8.76953   -11.81733 1.000 35.47890 ? 404 LEU B CB  1 
ATOM   2458 C CG  . LEU B 1 52  ? 18.47321  9.46571   -12.60797 1.000 37.75869 ? 404 LEU B CG  1 
ATOM   2459 C CD1 . LEU B 1 52  ? 19.07598  10.65134  -13.34598 1.000 36.17120 ? 404 LEU B CD1 1 
ATOM   2460 C CD2 . LEU B 1 52  ? 17.80290  8.48562   -13.56899 1.000 36.55583 ? 404 LEU B CD2 1 
ATOM   2461 N N   . LYS B 1 53  ? 20.86535  5.73315   -11.32411 1.000 38.79388 ? 405 LYS B N   1 
ATOM   2462 C CA  . LYS B 1 53  ? 22.03102  4.97378   -10.89157 1.000 37.48815 ? 405 LYS B CA  1 
ATOM   2463 C C   . LYS B 1 53  ? 23.28788  5.84409   -10.86508 1.000 39.05687 ? 405 LYS B C   1 
ATOM   2464 O O   . LYS B 1 53  ? 23.37866  6.88112   -11.53323 1.000 40.40888 ? 405 LYS B O   1 
ATOM   2465 C CB  . LYS B 1 53  ? 22.26433  3.77697   -11.81694 1.000 35.37676 ? 405 LYS B CB  1 
ATOM   2466 C CG  . LYS B 1 53  ? 22.41802  4.13861   -13.30393 1.000 44.28137 ? 405 LYS B CG  1 
ATOM   2467 C CD  . LYS B 1 53  ? 23.87027  4.09783   -13.77578 1.000 57.75700 ? 405 LYS B CD  1 
ATOM   2468 C CE  . LYS B 1 53  ? 24.15421  2.88957   -14.66590 1.000 57.56090 ? 405 LYS B CE  1 
ATOM   2469 N NZ  . LYS B 1 53  ? 25.46623  3.01188   -15.40927 1.000 67.29161 ? 405 LYS B NZ  1 
ATOM   2470 N N   . ASN B 1 54  ? 24.26247  5.39666   -10.06458 1.000 37.58267 ? 406 ASN B N   1 
ATOM   2471 C CA  . ASN B 1 54  ? 25.62383  5.93888   -10.05099 1.000 42.25255 ? 406 ASN B CA  1 
ATOM   2472 C C   . ASN B 1 54  ? 25.62071  7.45530   -9.89065  1.000 44.35311 ? 406 ASN B C   1 
ATOM   2473 O O   . ASN B 1 54  ? 26.23654  8.18324   -10.67269 1.000 43.09810 ? 406 ASN B O   1 
ATOM   2474 C CB  . ASN B 1 54  ? 26.37712  5.52903   -11.31591 1.000 36.21408 ? 406 ASN B CB  1 
ATOM   2475 C CG  . ASN B 1 54  ? 27.87681  5.73426   -11.19569 1.000 39.43932 ? 406 ASN B CG  1 
ATOM   2476 O OD1 . ASN B 1 54  ? 28.41651  5.83781   -10.09263 1.000 46.08213 ? 406 ASN B OD1 1 
ATOM   2477 N ND2 . ASN B 1 54  ? 28.55258  5.79991   -12.32910 1.000 37.72010 ? 406 ASN B ND2 1 
ATOM   2478 N N   . GLU B 1 55  ? 24.87359  7.92851   -8.88454  1.000 40.09917 ? 407 GLU B N   1 
ATOM   2479 C CA  . GLU B 1 55  ? 24.78120  9.35560   -8.54545  1.000 45.65188 ? 407 GLU B CA  1 
ATOM   2480 C C   . GLU B 1 55  ? 24.40164  10.22391  -9.74634  1.000 40.25936 ? 407 GLU B C   1 
ATOM   2481 O O   . GLU B 1 55  ? 24.70710  11.41988  -9.77888  1.000 46.20071 ? 407 GLU B O   1 
ATOM   2482 C CB  . GLU B 1 55  ? 26.08652  9.85660   -7.92419  1.000 42.85888 ? 407 GLU B CB  1 
ATOM   2483 C CG  . GLU B 1 55  ? 26.32557  9.36091   -6.52105  1.000 52.88106 ? 407 GLU B CG  1 
ATOM   2484 C CD  . GLU B 1 55  ? 27.55768  9.98114   -5.90746  1.000 61.50311 ? 407 GLU B CD  1 
ATOM   2485 O OE1 . GLU B 1 55  ? 28.43595  10.43237  -6.67286  1.000 72.68794 ? 407 GLU B OE1 1 
ATOM   2486 O OE2 . GLU B 1 55  ? 27.64408  10.02707  -4.66562  1.000 60.34164 ? 407 GLU B OE2 1 
ATOM   2487 N N   . ALA B 1 56  ? 23.72175  9.62664   -10.72983 1.000 35.96487 ? 408 ALA B N   1 
ATOM   2488 C CA  . ALA B 1 56  ? 23.32424  10.30729  -11.96459 1.000 34.43493 ? 408 ALA B CA  1 
ATOM   2489 C C   . ALA B 1 56  ? 24.52844  10.88506  -12.70138 1.000 47.96633 ? 408 ALA B C   1 
ATOM   2490 O O   . ALA B 1 56  ? 24.50131  12.02848  -13.16102 1.000 50.69730 ? 408 ALA B O   1 
ATOM   2491 C CB  . ALA B 1 56  ? 22.28824  11.40274  -11.69155 1.000 40.31218 ? 408 ALA B CB  1 
ATOM   2492 N N   . ASN B 1 57  ? 25.59894  10.09216  -12.81698 1.000 42.84275 ? 409 ASN B N   1 
ATOM   2493 C CA  . ASN B 1 57  ? 26.76362  10.56416  -13.55670 1.000 43.68823 ? 409 ASN B CA  1 
ATOM   2494 C C   . ASN B 1 57  ? 26.52095  10.55844  -15.06491 1.000 44.70081 ? 409 ASN B C   1 
ATOM   2495 O O   . ASN B 1 57  ? 27.12008  11.36291  -15.79022 1.000 43.29821 ? 409 ASN B O   1 
ATOM   2496 C CB  . ASN B 1 57  ? 27.98345  9.72528   -13.18114 1.000 36.20202 ? 409 ASN B CB  1 
ATOM   2497 C CG  . ASN B 1 57  ? 28.60223  10.16905  -11.87510 1.000 38.16233 ? 409 ASN B CG  1 
ATOM   2498 O OD1 . ASN B 1 57  ? 28.61563  11.36181  -11.56102 1.000 39.71354 ? 409 ASN B OD1 1 
ATOM   2499 N ND2 . ASN B 1 57  ? 29.11886  9.21789   -11.10463 1.000 39.33835 ? 409 ASN B ND2 1 
ATOM   2500 N N   . ASP B 1 58  ? 25.64213  9.68915   -15.54875 1.000 40.47246 ? 410 ASP B N   1 
ATOM   2501 C CA  . ASP B 1 58  ? 25.31918  9.63657   -16.97601 1.000 42.89534 ? 410 ASP B CA  1 
ATOM   2502 C C   . ASP B 1 58  ? 24.53494  10.88467  -17.38801 1.000 52.40179 ? 410 ASP B C   1 
ATOM   2503 O O   . ASP B 1 58  ? 23.41344  11.09599  -16.89633 1.000 49.33869 ? 410 ASP B O   1 
ATOM   2504 C CB  . ASP B 1 58  ? 24.52358  8.35021   -17.26998 1.000 42.47874 ? 410 ASP B CB  1 
ATOM   2505 C CG  . ASP B 1 58  ? 24.27652  8.11798   -18.76309 1.000 42.68963 ? 410 ASP B CG  1 
ATOM   2506 O OD1 . ASP B 1 58  ? 24.32991  9.09510   -19.54801 1.000 48.71114 ? 410 ASP B OD1 1 
ATOM   2507 O OD2 . ASP B 1 58  ? 24.01926  6.95055   -19.14965 1.000 37.75190 ? 410 ASP B OD2 1 
ATOM   2508 N N   . PRO B 1 59  ? 25.06629  11.72944  -18.27982 1.000 52.47922 ? 411 PRO B N   1 
ATOM   2509 C CA  . PRO B 1 59  ? 24.30236  12.92062  -18.68860 1.000 47.70274 ? 411 PRO B CA  1 
ATOM   2510 C C   . PRO B 1 59  ? 23.02201  12.58429  -19.43842 1.000 50.19132 ? 411 PRO B C   1 
ATOM   2511 O O   . PRO B 1 59  ? 22.04523  13.33848  -19.34336 1.000 49.58820 ? 411 PRO B O   1 
ATOM   2512 C CB  . PRO B 1 59  ? 25.29273  13.69165  -19.57534 1.000 55.46411 ? 411 PRO B CB  1 
ATOM   2513 C CG  . PRO B 1 59  ? 26.64743  13.09442  -19.27829 1.000 59.64609 ? 411 PRO B CG  1 
ATOM   2514 C CD  . PRO B 1 59  ? 26.38476  11.66529  -18.93199 1.000 49.47894 ? 411 PRO B CD  1 
ATOM   2515 N N   . ALA B 1 60  ? 22.99450  11.47446  -20.18423 1.000 46.54154 ? 412 ALA B N   1 
ATOM   2516 C CA  . ALA B 1 60  ? 21.77506  11.09169  -20.88803 1.000 50.39250 ? 412 ALA B CA  1 
ATOM   2517 C C   . ALA B 1 60  ? 20.65956  10.74462  -19.90787 1.000 51.46413 ? 412 ALA B C   1 
ATOM   2518 O O   . ALA B 1 60  ? 19.48119  11.01994  -20.17439 1.000 45.25694 ? 412 ALA B O   1 
ATOM   2519 C CB  . ALA B 1 60  ? 22.05487  9.91854   -21.83014 1.000 48.90287 ? 412 ALA B CB  1 
ATOM   2520 N N   . LEU B 1 61  ? 21.01303  10.13876  -18.76530 1.000 39.56510 ? 413 LEU B N   1 
ATOM   2521 C CA  . LEU B 1 61  ? 20.00704  9.80599   -17.75807 1.000 44.14526 ? 413 LEU B CA  1 
ATOM   2522 C C   . LEU B 1 61  ? 19.49553  11.05511  -17.05116 1.000 39.15363 ? 413 LEU B C   1 
ATOM   2523 O O   . LEU B 1 61  ? 18.29192  11.17323  -16.78748 1.000 38.50464 ? 413 LEU B O   1 
ATOM   2524 C CB  . LEU B 1 61  ? 20.57690  8.82025   -16.73763 1.000 38.35474 ? 413 LEU B CB  1 
ATOM   2525 C CG  . LEU B 1 61  ? 20.77058  7.37262   -17.19958 1.000 43.06739 ? 413 LEU B CG  1 
ATOM   2526 C CD1 . LEU B 1 61  ? 21.23025  6.48818   -16.03663 1.000 43.91975 ? 413 LEU B CD1 1 
ATOM   2527 C CD2 . LEU B 1 61  ? 19.49060  6.82886   -17.84992 1.000 40.29254 ? 413 LEU B CD2 1 
ATOM   2528 N N   . LYS B 1 62  ? 20.39822  11.99006  -16.72967 1.000 40.23176 ? 414 LYS B N   1 
ATOM   2529 C CA  . LYS B 1 62  ? 19.99820  13.24562  -16.09918 1.000 42.02037 ? 414 LYS B CA  1 
ATOM   2530 C C   . LYS B 1 62  ? 19.09731  14.06378  -17.01686 1.000 45.91398 ? 414 LYS B C   1 
ATOM   2531 O O   . LYS B 1 62  ? 18.07940  14.61780  -16.58192 1.000 41.94478 ? 414 LYS B O   1 
ATOM   2532 C CB  . LYS B 1 62  ? 21.23993  14.04384  -15.72164 1.000 46.99732 ? 414 LYS B CB  1 
ATOM   2533 C CG  . LYS B 1 62  ? 21.12376  14.82409  -14.42356 1.000 54.65155 ? 414 LYS B CG  1 
ATOM   2534 C CD  . LYS B 1 62  ? 22.40801  15.61098  -14.15153 1.000 55.31676 ? 414 LYS B CD  1 
ATOM   2535 C CE  . LYS B 1 62  ? 23.64177  14.73891  -14.37202 1.000 57.67279 ? 414 LYS B CE  1 
ATOM   2536 N NZ  . LYS B 1 62  ? 24.92927  15.48365  -14.22679 1.000 64.58254 ? 414 LYS B NZ  1 
ATOM   2537 N N   . ASP B 1 63  ? 19.47035  14.16660  -18.29422 1.000 47.13614 ? 415 ASP B N   1 
ATOM   2538 C CA  . ASP B 1 63  ? 18.64322  14.89572  -19.24984 1.000 44.29988 ? 415 ASP B CA  1 
ATOM   2539 C C   . ASP B 1 63  ? 17.29011  14.22635  -19.45611 1.000 41.14394 ? 415 ASP B C   1 
ATOM   2540 O O   . ASP B 1 63  ? 16.28292  14.92065  -19.61777 1.000 42.28555 ? 415 ASP B O   1 
ATOM   2541 C CB  . ASP B 1 63  ? 19.37556  15.02511  -20.58472 1.000 52.74888 ? 415 ASP B CB  1 
ATOM   2542 C CG  . ASP B 1 63  ? 20.65172  15.84587  -20.47534 1.000 55.01710 ? 415 ASP B CG  1 
ATOM   2543 O OD1 . ASP B 1 63  ? 20.74458  16.67984  -19.54569 1.000 65.47121 ? 415 ASP B OD1 1 
ATOM   2544 O OD2 . ASP B 1 63  ? 21.55642  15.65649  -21.32113 1.000 65.87417 ? 415 ASP B OD2 1 
ATOM   2545 N N   . GLU B 1 64  ? 17.24677  12.88749  -19.46256 1.000 36.38399 ? 416 GLU B N   1 
ATOM   2546 C CA  . GLU B 1 64  ? 15.97310  12.18631  -19.59990 1.000 39.50446 ? 416 GLU B CA  1 
ATOM   2547 C C   . GLU B 1 64  ? 15.06500  12.45764  -18.40229 1.000 45.53702 ? 416 GLU B C   1 
ATOM   2548 O O   . GLU B 1 64  ? 13.85727  12.65748  -18.57228 1.000 41.02004 ? 416 GLU B O   1 
ATOM   2549 C CB  . GLU B 1 64  ? 16.21350  10.68422  -19.78573 1.000 39.31734 ? 416 GLU B CB  1 
ATOM   2550 C CG  . GLU B 1 64  ? 14.95123  9.82645   -19.81940 1.000 49.27808 ? 416 GLU B CG  1 
ATOM   2551 C CD  . GLU B 1 64  ? 15.21936  8.37050   -20.22250 1.000 61.71545 ? 416 GLU B CD  1 
ATOM   2552 O OE1 . GLU B 1 64  ? 16.24260  7.79451   -19.78762 1.000 58.00531 ? 416 GLU B OE1 1 
ATOM   2553 O OE2 . GLU B 1 64  ? 14.40244  7.80675   -20.98667 1.000 58.96619 ? 416 GLU B OE2 1 
ATOM   2554 N N   . LEU B 1 65  ? 15.62807  12.49565  -17.18667 1.000 40.94328 ? 417 LEU B N   1 
ATOM   2555 C CA  . LEU B 1 65  ? 14.80938  12.74037  -16.00000 1.000 33.61690 ? 417 LEU B CA  1 
ATOM   2556 C C   . LEU B 1 65  ? 14.23116  14.15235  -15.99748 1.000 36.24079 ? 417 LEU B C   1 
ATOM   2557 O O   . LEU B 1 65  ? 13.06239  14.34799  -15.65158 1.000 35.77784 ? 417 LEU B O   1 
ATOM   2558 C CB  . LEU B 1 65  ? 15.62213  12.50498  -14.72700 1.000 34.11955 ? 417 LEU B CB  1 
ATOM   2559 C CG  . LEU B 1 65  ? 14.69514  12.33083  -13.52599 1.000 43.77756 ? 417 LEU B CG  1 
ATOM   2560 C CD1 . LEU B 1 65  ? 13.90295  11.04633  -13.70537 1.000 45.47772 ? 417 LEU B CD1 1 
ATOM   2561 C CD2 . LEU B 1 65  ? 15.45009  12.32273  -12.21111 1.000 42.19438 ? 417 LEU B CD2 1 
ATOM   2562 N N   . LEU B 1 66  ? 15.02385  15.15036  -16.38612 1.000 43.01253 ? 418 LEU B N   1 
ATOM   2563 C CA  . LEU B 1 66  ? 14.51620  16.52179  -16.36866 1.000 47.10686 ? 418 LEU B CA  1 
ATOM   2564 C C   . LEU B 1 66  ? 13.47916  16.75719  -17.46502 1.000 41.67177 ? 418 LEU B C   1 
ATOM   2565 O O   . LEU B 1 66  ? 12.53060  17.52620  -17.26813 1.000 37.99843 ? 418 LEU B O   1 
ATOM   2566 C CB  . LEU B 1 66  ? 15.66892  17.51833  -16.48669 1.000 53.03931 ? 418 LEU B CB  1 
ATOM   2567 C CG  . LEU B 1 66  ? 16.39835  17.81700  -15.16836 1.000 60.55979 ? 418 LEU B CG  1 
ATOM   2568 C CD1 . LEU B 1 66  ? 17.28614  19.04775  -15.29874 1.000 68.38257 ? 418 LEU B CD1 1 
ATOM   2569 C CD2 . LEU B 1 66  ? 15.41653  17.98205  -14.00490 1.000 59.88812 ? 418 LEU B CD2 1 
ATOM   2570 N N   . ALA B 1 67  ? 13.63843  16.10813  -18.62294 1.000 36.80942 ? 419 ALA B N   1 
ATOM   2571 C CA  . ALA B 1 67  ? 12.62259  16.19986  -19.66998 1.000 40.80742 ? 419 ALA B CA  1 
ATOM   2572 C C   . ALA B 1 67  ? 11.33684  15.50995  -19.23486 1.000 39.87728 ? 419 ALA B C   1 
ATOM   2573 O O   . ALA B 1 67  ? 10.23109  16.05245  -19.39166 1.000 42.66796 ? 419 ALA B O   1 
ATOM   2574 C CB  . ALA B 1 67  ? 13.14672  15.57853  -20.96644 1.000 40.34941 ? 419 ALA B CB  1 
ATOM   2575 N N   . GLU B 1 68  ? 11.47673  14.28514  -18.72714 1.000 37.34415 ? 420 GLU B N   1 
ATOM   2576 C CA  . GLU B 1 68  ? 10.38451  13.55241  -18.10308 1.000 33.30303 ? 420 GLU B CA  1 
ATOM   2577 C C   . GLU B 1 68  ? 9.60923   14.43465  -17.12655 1.000 32.70431 ? 420 GLU B C   1 
ATOM   2578 O O   . GLU B 1 68  ? 8.37605   14.50996  -17.17597 1.000 29.95513 ? 420 GLU B O   1 
ATOM   2579 C CB  . GLU B 1 68  ? 10.99509  12.33546  -17.40131 1.000 35.63077 ? 420 GLU B CB  1 
ATOM   2580 C CG  . GLU B 1 68  ? 10.08197  11.38674  -16.70608 1.000 41.95982 ? 420 GLU B CG  1 
ATOM   2581 C CD  . GLU B 1 68  ? 10.78626  10.06888  -16.42330 1.000 44.72737 ? 420 GLU B CD  1 
ATOM   2582 O OE1 . GLU B 1 68  ? 12.04046  10.06908  -16.26654 1.000 42.36485 ? 420 GLU B OE1 1 
ATOM   2583 O OE2 . GLU B 1 68  ? 10.08646  9.03667   -16.37149 1.000 38.79378 ? 420 GLU B OE2 1 
ATOM   2584 N N   . ALA B 1 69  ? 10.31909  15.11940  -16.23209 1.000 33.57461 ? 421 ALA B N   1 
ATOM   2585 C CA  . ALA B 1 69  ? 9.63322   15.94593  -15.23973 1.000 34.52635 ? 421 ALA B CA  1 
ATOM   2586 C C   . ALA B 1 69  ? 9.00348   17.18445  -15.87039 1.000 35.99360 ? 421 ALA B C   1 
ATOM   2587 O O   . ALA B 1 69  ? 7.90721   17.60496  -15.47416 1.000 33.29360 ? 421 ALA B O   1 
ATOM   2588 C CB  . ALA B 1 69  ? 10.61074  16.34151  -14.14435 1.000 42.42072 ? 421 ALA B CB  1 
ATOM   2589 N N   . ASN B 1 70  ? 9.68116   17.78264  -16.85272 1.000 39.28677 ? 422 ASN B N   1 
ATOM   2590 C CA  . ASN B 1 70  ? 9.11780   18.93556  -17.55203 1.000 37.15635 ? 422 ASN B CA  1 
ATOM   2591 C C   . ASN B 1 70  ? 7.79422   18.58639  -18.22759 1.000 37.00694 ? 422 ASN B C   1 
ATOM   2592 O O   . ASN B 1 70  ? 6.87093   19.41374  -18.27328 1.000 41.94587 ? 422 ASN B O   1 
ATOM   2593 C CB  . ASN B 1 70  ? 10.11836  19.46387  -18.57886 1.000 41.89268 ? 422 ASN B CB  1 
ATOM   2594 C CG  . ASN B 1 70  ? 9.49703   20.47301  -19.53547 1.000 57.04936 ? 422 ASN B CG  1 
ATOM   2595 O OD1 . ASN B 1 70  ? 9.14853   20.14209  -20.67488 1.000 56.80135 ? 422 ASN B OD1 1 
ATOM   2596 N ND2 . ASN B 1 70  ? 9.35219   21.70969  -19.07343 1.000 51.87612 ? 422 ASN B ND2 1 
ATOM   2597 N N   . VAL B 1 71  ? 7.67196   17.35990  -18.74202 1.000 32.36962 ? 423 VAL B N   1 
ATOM   2598 C CA  . VAL B 1 71  ? 6.41683   16.94977  -19.36018 1.000 30.92904 ? 423 VAL B CA  1 
ATOM   2599 C C   . VAL B 1 71  ? 5.36064   16.71402  -18.29237 1.000 30.69706 ? 423 VAL B C   1 
ATOM   2600 O O   . VAL B 1 71  ? 4.21940   17.17413  -18.41301 1.000 38.95583 ? 423 VAL B O   1 
ATOM   2601 C CB  . VAL B 1 71  ? 6.61032   15.69082  -20.22927 1.000 29.89403 ? 423 VAL B CB  1 
ATOM   2602 C CG1 . VAL B 1 71  ? 5.24431   15.21404  -20.77253 1.000 30.38862 ? 423 VAL B CG1 1 
ATOM   2603 C CG2 . VAL B 1 71  ? 7.58816   15.96121  -21.37093 1.000 32.12029 ? 423 VAL B CG2 1 
ATOM   2604 N N   . MET B 1 72  ? 5.71958   15.97303  -17.24059 1.000 29.69160 ? 424 MET B N   1 
ATOM   2605 C CA  . MET B 1 72  ? 4.73324   15.58869  -16.23505 1.000 32.77527 ? 424 MET B CA  1 
ATOM   2606 C C   . MET B 1 72  ? 4.16470   16.80641  -15.51790 1.000 32.06820 ? 424 MET B C   1 
ATOM   2607 O O   . MET B 1 72  ? 2.96927   16.84460  -15.20412 1.000 33.20322 ? 424 MET B O   1 
ATOM   2608 C CB  . MET B 1 72  ? 5.35167   14.61002  -15.23976 1.000 32.24686 ? 424 MET B CB  1 
ATOM   2609 C CG  . MET B 1 72  ? 5.78967   13.28280  -15.86558 1.000 29.04664 ? 424 MET B CG  1 
ATOM   2610 S SD  . MET B 1 72  ? 6.22761   12.05226  -14.59754 1.000 33.04158 ? 424 MET B SD  1 
ATOM   2611 C CE  . MET B 1 72  ? 4.62172   11.32153  -14.21523 1.000 26.34807 ? 424 MET B CE  1 
ATOM   2612 N N   . GLN B 1 73  ? 4.99673   17.82279  -15.28319 1.000 33.80690 ? 425 GLN B N   1 
ATOM   2613 C CA  . GLN B 1 73  ? 4.53335   19.05253  -14.64117 1.000 39.39932 ? 425 GLN B CA  1 
ATOM   2614 C C   . GLN B 1 73  ? 3.41043   19.73167  -15.42527 1.000 41.14128 ? 425 GLN B C   1 
ATOM   2615 O O   . GLN B 1 73  ? 2.61975   20.47924  -14.83699 1.000 38.84775 ? 425 GLN B O   1 
ATOM   2616 C CB  . GLN B 1 73  ? 5.70968   20.02254  -14.47118 1.000 40.58143 ? 425 GLN B CB  1 
ATOM   2617 C CG  . GLN B 1 73  ? 5.38031   21.33763  -13.75385 1.000 49.74608 ? 425 GLN B CG  1 
ATOM   2618 C CD  . GLN B 1 73  ? 6.58655   22.26420  -13.65718 1.000 63.48929 ? 425 GLN B CD  1 
ATOM   2619 O OE1 . GLN B 1 73  ? 7.54233   22.14584  -14.43238 1.000 56.00291 ? 425 GLN B OE1 1 
ATOM   2620 N NE2 . GLN B 1 73  ? 6.54975   23.18939  -12.69785 1.000 66.69732 ? 425 GLN B NE2 1 
ATOM   2621 N N   . GLN B 1 74  ? 3.31789   19.48721  -16.73409 1.000 33.56290 ? 426 GLN B N   1 
ATOM   2622 C CA  . GLN B 1 74  ? 2.30458   20.10402  -17.57725 1.000 36.25004 ? 426 GLN B CA  1 
ATOM   2623 C C   . GLN B 1 74  ? 1.00444   19.31417  -17.66074 1.000 37.15656 ? 426 GLN B C   1 
ATOM   2624 O O   . GLN B 1 74  ? -0.00286  19.86553  -18.11216 1.000 38.37029 ? 426 GLN B O   1 
ATOM   2625 C CB  . GLN B 1 74  ? 2.86255   20.29892  -18.98678 1.000 32.81996 ? 426 GLN B CB  1 
ATOM   2626 C CG  . GLN B 1 74  ? 4.13426   21.13154  -18.98748 1.000 39.21859 ? 426 GLN B CG  1 
ATOM   2627 C CD  . GLN B 1 74  ? 4.73256   21.31084  -20.36181 1.000 42.85605 ? 426 GLN B CD  1 
ATOM   2628 O OE1 . GLN B 1 74  ? 4.09536   21.86686  -21.26363 1.000 35.63036 ? 426 GLN B OE1 1 
ATOM   2629 N NE2 . GLN B 1 74  ? 5.97523   20.85010  -20.53166 1.000 40.56611 ? 426 GLN B NE2 1 
ATOM   2630 N N   . LEU B 1 75  ? 0.99207   18.05420  -17.24584 1.000 33.49955 ? 427 LEU B N   1 
ATOM   2631 C CA  . LEU B 1 75  ? -0.15139  17.18304  -17.46695 1.000 31.49936 ? 427 LEU B CA  1 
ATOM   2632 C C   . LEU B 1 75  ? -1.00947  17.08159  -16.21471 1.000 32.27970 ? 427 LEU B C   1 
ATOM   2633 O O   . LEU B 1 75  ? -0.50654  17.03463  -15.09088 1.000 36.23684 ? 427 LEU B O   1 
ATOM   2634 C CB  . LEU B 1 75  ? 0.31184   15.78879  -17.90071 1.000 31.02227 ? 427 LEU B CB  1 
ATOM   2635 C CG  . LEU B 1 75  ? 1.30641   15.80411  -19.06968 1.000 31.93450 ? 427 LEU B CG  1 
ATOM   2636 C CD1 . LEU B 1 75  ? 1.80209   14.39360  -19.37851 1.000 35.89880 ? 427 LEU B CD1 1 
ATOM   2637 C CD2 . LEU B 1 75  ? 0.67888   16.44147  -20.31597 1.000 36.02284 ? 427 LEU B CD2 1 
ATOM   2638 N N   . ASP B 1 76  ? -2.31916  17.01275  -16.42983 1.000 35.72884 ? 428 ASP B N   1 
ATOM   2639 C CA  . ASP B 1 76  ? -3.29879  16.99414  -15.34366 1.000 36.16206 ? 428 ASP B CA  1 
ATOM   2640 C C   . ASP B 1 76  ? -4.48752  16.19224  -15.86908 1.000 36.22644 ? 428 ASP B C   1 
ATOM   2641 O O   . ASP B 1 76  ? -5.35818  16.73012  -16.54785 1.000 35.82395 ? 428 ASP B O   1 
ATOM   2642 C CB  . ASP B 1 76  ? -3.69800  18.40975  -14.94427 1.000 38.97669 ? 428 ASP B CB  1 
ATOM   2643 C CG  . ASP B 1 76  ? -4.38957  18.47469  -13.59033 1.000 52.66507 ? 428 ASP B CG  1 
ATOM   2644 O OD1 . ASP B 1 76  ? -4.69512  17.41485  -13.01217 1.000 41.24953 ? 428 ASP B OD1 1 
ATOM   2645 O OD2 . ASP B 1 76  ? -4.61200  19.60310  -13.09657 1.000 57.14236 ? 428 ASP B OD2 1 
ATOM   2646 N N   . ASN B 1 77  ? -4.48219  14.89097  -15.59124 1.000 40.06444 ? 429 ASN B N   1 
ATOM   2647 C CA  . ASN B 1 77  ? -5.52356  14.01708  -16.09918 1.000 35.08397 ? 429 ASN B CA  1 
ATOM   2648 C C   . ASN B 1 77  ? -5.57429  12.82900  -15.16766 1.000 34.26984 ? 429 ASN B C   1 
ATOM   2649 O O   . ASN B 1 77  ? -4.51320  12.36769  -14.72275 1.000 28.77053 ? 429 ASN B O   1 
ATOM   2650 C CB  . ASN B 1 77  ? -5.25226  13.55213  -17.53273 1.000 33.22163 ? 429 ASN B CB  1 
ATOM   2651 C CG  . ASN B 1 77  ? -6.32964  12.61455  -18.05439 1.000 36.90982 ? 429 ASN B CG  1 
ATOM   2652 O OD1 . ASN B 1 77  ? -6.18387  11.38563  -18.00430 1.000 31.16282 ? 429 ASN B OD1 1 
ATOM   2653 N ND2 . ASN B 1 77  ? -7.42106  13.18903  -18.56070 1.000 30.40589 ? 429 ASN B ND2 1 
ATOM   2654 N N   . PRO B 1 78  ? -6.76399  12.31084  -14.84856 1.000 28.00687 ? 430 PRO B N   1 
ATOM   2655 C CA  . PRO B 1 78  ? -6.86336  11.18159  -13.91107 1.000 32.04454 ? 430 PRO B CA  1 
ATOM   2656 C C   . PRO B 1 78  ? -6.22089  9.89232   -14.40490 1.000 32.08833 ? 430 PRO B C   1 
ATOM   2657 O O   . PRO B 1 78  ? -5.98305  8.99036   -13.59232 1.000 29.53279 ? 430 PRO B O   1 
ATOM   2658 C CB  . PRO B 1 78  ? -8.38030  11.00758  -13.72894 1.000 38.14879 ? 430 PRO B CB  1 
ATOM   2659 C CG  . PRO B 1 78  ? -9.00286  11.72883  -14.88700 1.000 36.12337 ? 430 PRO B CG  1 
ATOM   2660 C CD  . PRO B 1 78  ? -8.08211  12.84357  -15.23467 1.000 38.38277 ? 430 PRO B CD  1 
ATOM   2661 N N   . TYR B 1 79  ? -5.90730  9.76749   -15.69009 1.000 29.99081 ? 431 TYR B N   1 
ATOM   2662 C CA  . TYR B 1 79  ? -5.32688  8.52841   -16.18254 1.000 28.74983 ? 431 TYR B CA  1 
ATOM   2663 C C   . TYR B 1 79  ? -3.86081  8.70223   -16.55555 1.000 26.36375 ? 431 TYR B C   1 
ATOM   2664 O O   . TYR B 1 79  ? -3.33407  7.93971   -17.37203 1.000 27.19439 ? 431 TYR B O   1 
ATOM   2665 C CB  . TYR B 1 79  ? -6.13861  8.00599   -17.36346 1.000 28.55150 ? 431 TYR B CB  1 
ATOM   2666 C CG  . TYR B 1 79  ? -7.61909  7.95638   -17.02698 1.000 32.20280 ? 431 TYR B CG  1 
ATOM   2667 C CD1 . TYR B 1 79  ? -8.13905  6.97220   -16.18565 1.000 32.84952 ? 431 TYR B CD1 1 
ATOM   2668 C CD2 . TYR B 1 79  ? -8.48138  8.92465   -17.51484 1.000 36.62339 ? 431 TYR B CD2 1 
ATOM   2669 C CE1 . TYR B 1 79  ? -9.50318  6.95101   -15.85633 1.000 30.59093 ? 431 TYR B CE1 1 
ATOM   2670 C CE2 . TYR B 1 79  ? -9.82467  8.91221   -17.19619 1.000 33.55641 ? 431 TYR B CE2 1 
ATOM   2671 C CZ  . TYR B 1 79  ? -10.32649 7.93252   -16.37650 1.000 34.20141 ? 431 TYR B CZ  1 
ATOM   2672 O OH  . TYR B 1 79  ? -11.68170 7.96504   -16.10248 1.000 41.03500 ? 431 TYR B OH  1 
ATOM   2673 N N   . ILE B 1 80  ? -3.20648  9.70314   -15.97566 1.000 27.38326 ? 432 ILE B N   1 
ATOM   2674 C CA  . ILE B 1 80  ? -1.77145  9.93329   -16.12047 1.000 25.89056 ? 432 ILE B CA  1 
ATOM   2675 C C   . ILE B 1 80  ? -1.17834  10.02993  -14.72138 1.000 31.23661 ? 432 ILE B C   1 
ATOM   2676 O O   . ILE B 1 80  ? -1.75040  10.69084  -13.84579 1.000 30.58785 ? 432 ILE B O   1 
ATOM   2677 C CB  . ILE B 1 80  ? -1.49800  11.20711  -16.94319 1.000 28.48527 ? 432 ILE B CB  1 
ATOM   2678 C CG1 . ILE B 1 80  ? -2.14793  11.06488  -18.32818 1.000 27.62078 ? 432 ILE B CG1 1 
ATOM   2679 C CG2 . ILE B 1 80  ? 0.01151   11.48124  -17.05650 1.000 27.78358 ? 432 ILE B CG2 1 
ATOM   2680 C CD1 . ILE B 1 80  ? -1.69456  12.06222  -19.33523 1.000 34.40873 ? 432 ILE B CD1 1 
ATOM   2681 N N   . VAL B 1 81  ? -0.04209  9.36303   -14.50278 1.000 28.04108 ? 433 VAL B N   1 
ATOM   2682 C CA  . VAL B 1 81  ? 0.60165   9.42815   -13.19483 1.000 29.05931 ? 433 VAL B CA  1 
ATOM   2683 C C   . VAL B 1 81  ? 0.98135   10.86982  -12.87546 1.000 32.54392 ? 433 VAL B C   1 
ATOM   2684 O O   . VAL B 1 81  ? 1.51619   11.60900  -13.71885 1.000 25.39380 ? 433 VAL B O   1 
ATOM   2685 C CB  . VAL B 1 81  ? 1.80908   8.47831   -13.14487 1.000 29.22356 ? 433 VAL B CB  1 
ATOM   2686 C CG1 . VAL B 1 81  ? 2.60277   8.66840   -11.87029 1.000 32.17970 ? 433 VAL B CG1 1 
ATOM   2687 C CG2 . VAL B 1 81  ? 1.32623   7.02743   -13.20637 1.000 30.55368 ? 433 VAL B CG2 1 
ATOM   2688 N N   . ARG B 1 82  ? 0.67578   11.27749  -11.64800 1.000 31.68757 ? 434 ARG B N   1 
ATOM   2689 C CA  . ARG B 1 82  ? 0.93410   12.62008  -11.15324 1.000 25.06941 ? 434 ARG B CA  1 
ATOM   2690 C C   . ARG B 1 82  ? 2.34489   12.68972  -10.57472 1.000 30.02758 ? 434 ARG B C   1 
ATOM   2691 O O   . ARG B 1 82  ? 2.73963   11.81862  -9.80126  1.000 28.32444 ? 434 ARG B O   1 
ATOM   2692 C CB  . ARG B 1 82  ? -0.10262  12.95937  -10.08537 1.000 34.79938 ? 434 ARG B CB  1 
ATOM   2693 C CG  . ARG B 1 82  ? -0.05968  14.35556  -9.54875  1.000 47.54201 ? 434 ARG B CG  1 
ATOM   2694 C CD  . ARG B 1 82  ? -1.46473  14.75614  -9.07324  1.000 60.86760 ? 434 ARG B CD  1 
ATOM   2695 N NE  . ARG B 1 82  ? -1.66909  16.20074  -9.09477  1.000 71.05065 ? 434 ARG B NE  1 
ATOM   2696 C CZ  . ARG B 1 82  ? -1.81470  16.92163  -10.20073 1.000 72.88850 ? 434 ARG B CZ  1 
ATOM   2697 N NH1 . ARG B 1 82  ? -1.74968  16.36626  -11.40333 1.000 73.64228 ? 434 ARG B NH1 1 
ATOM   2698 N NH2 . ARG B 1 82  ? -2.01845  18.23445  -10.09927 1.000 67.71754 ? 434 ARG B NH2 1 
ATOM   2699 N N   . MET B 1 83  ? 3.10169   13.71700  -10.94955 1.000 24.55090 ? 435 MET B N   1 
ATOM   2700 C CA  . MET B 1 83  ? 4.43156   13.91686  -10.38402 1.000 30.23592 ? 435 MET B CA  1 
ATOM   2701 C C   . MET B 1 83  ? 4.34651   14.83376  -9.16750  1.000 33.01648 ? 435 MET B C   1 
ATOM   2702 O O   . MET B 1 83  ? 3.71559   15.89458  -9.23045  1.000 32.14300 ? 435 MET B O   1 
ATOM   2703 C CB  . MET B 1 83  ? 5.37601   14.52359  -11.42090 1.000 30.63094 ? 435 MET B CB  1 
ATOM   2704 C CG  . MET B 1 83  ? 6.72824   14.92672  -10.83373 1.000 37.76890 ? 435 MET B CG  1 
ATOM   2705 S SD  . MET B 1 83  ? 7.78592   15.79498  -12.01351 1.000 42.86821 ? 435 MET B SD  1 
ATOM   2706 C CE  . MET B 1 83  ? 6.76176   17.22448  -12.33330 1.000 31.07635 ? 435 MET B CE  1 
ATOM   2707 N N   . ILE B 1 84  ? 4.96463   14.41915  -8.05951  1.000 29.18036 ? 436 ILE B N   1 
ATOM   2708 C CA  . ILE B 1 84  ? 5.06366   15.30417  -6.90193  1.000 35.63906 ? 436 ILE B CA  1 
ATOM   2709 C C   . ILE B 1 84  ? 6.19287   16.31018  -7.09406  1.000 38.49436 ? 436 ILE B C   1 
ATOM   2710 O O   . ILE B 1 84  ? 6.01419   17.51044  -6.86953  1.000 31.89675 ? 436 ILE B O   1 
ATOM   2711 C CB  . ILE B 1 84  ? 5.26132   14.50371  -5.60184  1.000 33.34539 ? 436 ILE B CB  1 
ATOM   2712 C CG1 . ILE B 1 84  ? 4.15210   13.45657  -5.41464  1.000 36.56178 ? 436 ILE B CG1 1 
ATOM   2713 C CG2 . ILE B 1 84  ? 5.29862   15.46156  -4.42133  1.000 34.52897 ? 436 ILE B CG2 1 
ATOM   2714 C CD1 . ILE B 1 84  ? 2.75635   14.00350  -5.59737  1.000 34.93433 ? 436 ILE B CD1 1 
ATOM   2715 N N   . GLY B 1 85  ? 7.36730   15.83820  -7.49912  1.000 35.61737 ? 437 GLY B N   1 
ATOM   2716 C CA  . GLY B 1 85  ? 8.50080   16.72552  -7.68762  1.000 34.31857 ? 437 GLY B CA  1 
ATOM   2717 C C   . GLY B 1 85  ? 9.76812   15.95315  -7.98535  1.000 36.75381 ? 437 GLY B C   1 
ATOM   2718 O O   . GLY B 1 85  ? 9.76080   14.72896  -8.16668  1.000 32.20988 ? 437 GLY B O   1 
ATOM   2719 N N   . ILE B 1 86  ? 10.86577  16.70508  -8.06660  1.000 32.16476 ? 438 ILE B N   1 
ATOM   2720 C CA  . ILE B 1 86  ? 12.19591  16.15411  -8.29789  1.000 35.83079 ? 438 ILE B CA  1 
ATOM   2721 C C   . ILE B 1 86  ? 13.01014  16.41534  -7.04374  1.000 37.30229 ? 438 ILE B C   1 
ATOM   2722 O O   . ILE B 1 86  ? 12.86052  17.46347  -6.40951  1.000 36.69790 ? 438 ILE B O   1 
ATOM   2723 C CB  . ILE B 1 86  ? 12.89309  16.78445  -9.52160  1.000 49.35769 ? 438 ILE B CB  1 
ATOM   2724 C CG1 . ILE B 1 86  ? 12.01114  16.77636  -10.75774 1.000 51.21635 ? 438 ILE B CG1 1 
ATOM   2725 C CG2 . ILE B 1 86  ? 14.17384  16.05892  -9.86673  1.000 54.15805 ? 438 ILE B CG2 1 
ATOM   2726 C CD1 . ILE B 1 86  ? 12.56323  17.72731  -11.79783 1.000 66.66162 ? 438 ILE B CD1 1 
ATOM   2727 N N   . CYS B 1 87  ? 13.87817  15.47609  -6.68836  1.000 35.85088 ? 439 CYS B N   1 
ATOM   2728 C CA  . CYS B 1 87  ? 14.72152  15.63955  -5.51368  1.000 41.39386 ? 439 CYS B CA  1 
ATOM   2729 C C   . CYS B 1 87  ? 16.16726  15.40293  -5.91976  1.000 43.00120 ? 439 CYS B C   1 
ATOM   2730 O O   . CYS B 1 87  ? 16.49460  14.34295  -6.46760  1.000 42.74499 ? 439 CYS B O   1 
ATOM   2731 C CB  . CYS B 1 87  ? 14.29162  14.69119  -4.39190  1.000 39.49732 ? 439 CYS B CB  1 
ATOM   2732 S SG  . CYS B 1 87  ? 14.98823  15.11835  -2.79623  1.000 47.74166 ? 439 CYS B SG  1 
ATOM   2733 N N   . GLU B 1 88  ? 17.02452  16.39561  -5.66506  1.000 41.71353 ? 440 GLU B N   1 
ATOM   2734 C CA  . GLU B 1 88  ? 18.45965  16.30188  -5.93384  1.000 46.01444 ? 440 GLU B CA  1 
ATOM   2735 C C   . GLU B 1 88  ? 19.16516  16.03572  -4.60957  1.000 44.10513 ? 440 GLU B C   1 
ATOM   2736 O O   . GLU B 1 88  ? 19.38452  16.95314  -3.81551  1.000 46.57968 ? 440 GLU B O   1 
ATOM   2737 C CB  . GLU B 1 88  ? 18.97573  17.57656  -6.59149  1.000 53.84361 ? 440 GLU B CB  1 
ATOM   2738 C CG  . GLU B 1 88  ? 20.48467  17.62373  -6.72235  1.000 56.35475 ? 440 GLU B CG  1 
ATOM   2739 C CD  . GLU B 1 88  ? 20.99673  19.01377  -7.05539  1.000 78.00321 ? 440 GLU B CD  1 
ATOM   2740 O OE1 . GLU B 1 88  ? 20.25811  19.78234  -7.71505  1.000 66.17853 ? 440 GLU B OE1 1 
ATOM   2741 O OE2 . GLU B 1 88  ? 22.13545  19.33721  -6.64385  1.000 79.74853 ? 440 GLU B OE2 1 
ATOM   2742 N N   . ALA B 1 89  ? 19.51449  14.77387  -4.36904  1.000 48.46930 ? 441 ALA B N   1 
ATOM   2743 C CA  . ALA B 1 89  ? 20.17821  14.39410  -3.12704  1.000 42.67464 ? 441 ALA B CA  1 
ATOM   2744 C C   . ALA B 1 89  ? 21.34517  13.46179  -3.41992  1.000 42.95821 ? 441 ALA B C   1 
ATOM   2745 O O   . ALA B 1 89  ? 22.23465  13.81621  -4.20074  1.000 48.04816 ? 441 ALA B O   1 
ATOM   2746 C CB  . ALA B 1 89  ? 19.17708  13.74391  -2.17280  1.000 47.98458 ? 441 ALA B CB  1 
ATOM   2747 N N   . GLU B 1 90  ? 21.35142  12.27033  -2.80669  1.000 37.23373 ? 442 GLU B N   1 
ATOM   2748 C CA  . GLU B 1 90  ? 22.40600  11.29782  -3.09096  1.000 43.28685 ? 442 GLU B CA  1 
ATOM   2749 C C   . GLU B 1 90  ? 22.44139  10.92716  -4.56992  1.000 46.86486 ? 442 GLU B C   1 
ATOM   2750 O O   . GLU B 1 90  ? 23.50467  10.60611  -5.11368  1.000 47.69413 ? 442 GLU B O   1 
ATOM   2751 C CB  . GLU B 1 90  ? 22.23564  10.04497  -2.22139  1.000 40.63385 ? 442 GLU B CB  1 
ATOM   2752 C CG  . GLU B 1 90  ? 20.87784  9.33745   -2.31070  1.000 44.13924 ? 442 GLU B CG  1 
ATOM   2753 C CD  . GLU B 1 90  ? 19.91251  9.74969   -1.20836  1.000 39.49418 ? 442 GLU B CD  1 
ATOM   2754 O OE1 . GLU B 1 90  ? 19.65965  10.96310  -1.04863  1.000 41.27834 ? 442 GLU B OE1 1 
ATOM   2755 O OE2 . GLU B 1 90  ? 19.40401  8.85889   -0.49270  1.000 45.49752 ? 442 GLU B OE2 1 
ATOM   2756 N N   . SER B 1 91  ? 21.29394  10.95810  -5.23305  1.000 44.03633 ? 443 SER B N   1 
ATOM   2757 C CA  . SER B 1 91  ? 21.23204  10.94749  -6.68301  1.000 36.18446 ? 443 SER B CA  1 
ATOM   2758 C C   . SER B 1 91  ? 20.02123  11.78819  -7.06322  1.000 48.02055 ? 443 SER B C   1 
ATOM   2759 O O   . SER B 1 91  ? 19.32335  12.32593  -6.19696  1.000 41.53952 ? 443 SER B O   1 
ATOM   2760 C CB  . SER B 1 91  ? 21.17390  9.50871   -7.22329  1.000 39.17330 ? 443 SER B CB  1 
ATOM   2761 O OG  . SER B 1 91  ? 21.12370  9.46593   -8.64538  1.000 46.62441 ? 443 SER B OG  1 
ATOM   2762 N N   . TRP B 1 92  ? 19.78022  11.92670  -8.36014  1.000 38.24411 ? 444 TRP B N   1 
ATOM   2763 C CA  . TRP B 1 92  ? 18.58542  12.62566  -8.80663  1.000 40.65289 ? 444 TRP B CA  1 
ATOM   2764 C C   . TRP B 1 92  ? 17.39655  11.67673  -8.74272  1.000 34.86306 ? 444 TRP B C   1 
ATOM   2765 O O   . TRP B 1 92  ? 17.50486  10.50032  -9.10697  1.000 32.97535 ? 444 TRP B O   1 
ATOM   2766 C CB  . TRP B 1 92  ? 18.77742  13.17389  -10.22382 1.000 35.39798 ? 444 TRP B CB  1 
ATOM   2767 C CG  . TRP B 1 92  ? 19.57580  14.46761  -10.27531 1.000 56.07417 ? 444 TRP B CG  1 
ATOM   2768 C CD1 . TRP B 1 92  ? 20.93551  14.59662  -10.35695 1.000 53.70343 ? 444 TRP B CD1 1 
ATOM   2769 C CD2 . TRP B 1 92  ? 19.05025  15.80737  -10.24023 1.000 63.23398 ? 444 TRP B CD2 1 
ATOM   2770 N NE1 . TRP B 1 92  ? 21.28512  15.92876  -10.37823 1.000 53.26395 ? 444 TRP B NE1 1 
ATOM   2771 C CE2 . TRP B 1 92  ? 20.14930  16.69151  -10.30859 1.000 58.25712 ? 444 TRP B CE2 1 
ATOM   2772 C CE3 . TRP B 1 92  ? 17.75807  16.34211  -10.15710 1.000 58.57996 ? 444 TRP B CE3 1 
ATOM   2773 C CZ2 . TRP B 1 92  ? 19.99609  18.08193  -10.29376 1.000 53.14349 ? 444 TRP B CZ2 1 
ATOM   2774 C CZ3 . TRP B 1 92  ? 17.60804  17.72820  -10.14766 1.000 66.69653 ? 444 TRP B CZ3 1 
ATOM   2775 C CH2 . TRP B 1 92  ? 18.72282  18.57843  -10.21272 1.000 58.08598 ? 444 TRP B CH2 1 
ATOM   2776 N N   . MET B 1 93  ? 16.26319  12.18771  -8.25831  1.000 36.48854 ? 445 MET B N   1 
ATOM   2777 C CA  . MET B 1 93  ? 15.07483  11.37451  -8.02101  1.000 34.85749 ? 445 MET B CA  1 
ATOM   2778 C C   . MET B 1 93  ? 13.84282  12.06311  -8.57863  1.000 35.50836 ? 445 MET B C   1 
ATOM   2779 O O   . MET B 1 93  ? 13.70447  13.28347  -8.47973  1.000 33.67195 ? 445 MET B O   1 
ATOM   2780 C CB  . MET B 1 93  ? 14.83337  11.12529  -6.53714  1.000 35.94384 ? 445 MET B CB  1 
ATOM   2781 C CG  . MET B 1 93  ? 16.02195  10.57687  -5.79297  1.000 39.82488 ? 445 MET B CG  1 
ATOM   2782 S SD  . MET B 1 93  ? 15.67216  10.54514  -4.02772  1.000 39.95339 ? 445 MET B SD  1 
ATOM   2783 C CE  . MET B 1 93  ? 17.36100  10.33743  -3.47994  1.000 40.41457 ? 445 MET B CE  1 
ATOM   2784 N N   . LEU B 1 94  ? 12.93498  11.26296  -9.12202  1.000 28.92298 ? 446 LEU B N   1 
ATOM   2785 C CA  . LEU B 1 94  ? 11.64856  11.73256  -9.62103  1.000 29.11000 ? 446 LEU B CA  1 
ATOM   2786 C C   . LEU B 1 94  ? 10.56118  11.14845  -8.72689  1.000 31.14205 ? 446 LEU B C   1 
ATOM   2787 O O   . LEU B 1 94  ? 10.39921  9.92575   -8.67265  1.000 30.63606 ? 446 LEU B O   1 
ATOM   2788 C CB  . LEU B 1 94  ? 11.46057  11.30785  -11.07789 1.000 30.93450 ? 446 LEU B CB  1 
ATOM   2789 C CG  . LEU B 1 94  ? 10.46262  12.04056  -11.97575 1.000 44.69839 ? 446 LEU B CG  1 
ATOM   2790 C CD1 . LEU B 1 94  ? 9.07777   11.65804  -11.61469 1.000 41.39369 ? 446 LEU B CD1 1 
ATOM   2791 C CD2 . LEU B 1 94  ? 10.62366  13.53464  -11.82072 1.000 49.11795 ? 446 LEU B CD2 1 
ATOM   2792 N N   . VAL B 1 95  ? 9.83165   12.01291  -8.02372  1.000 28.83434 ? 447 VAL B N   1 
ATOM   2793 C CA  . VAL B 1 95  ? 8.88868   11.59009  -6.98475  1.000 26.63258 ? 447 VAL B CA  1 
ATOM   2794 C C   . VAL B 1 95  ? 7.47578   11.66063  -7.54637  1.000 24.08529 ? 447 VAL B C   1 
ATOM   2795 O O   . VAL B 1 95  ? 7.00809   12.73488  -7.94227  1.000 29.73725 ? 447 VAL B O   1 
ATOM   2796 C CB  . VAL B 1 95  ? 9.01180   12.45151  -5.71794  1.000 31.61706 ? 447 VAL B CB  1 
ATOM   2797 C CG1 . VAL B 1 95  ? 8.01485   11.97379  -4.66168  1.000 26.43728 ? 447 VAL B CG1 1 
ATOM   2798 C CG2 . VAL B 1 95  ? 10.45371  12.41518  -5.16768  1.000 27.78283 ? 447 VAL B CG2 1 
ATOM   2799 N N   . MET B 1 96  ? 6.78684   10.52655  -7.56624  1.000 24.07290 ? 448 MET B N   1 
ATOM   2800 C CA  . MET B 1 96  ? 5.45826   10.43431  -8.16275  1.000 27.69705 ? 448 MET B CA  1 
ATOM   2801 C C   . MET B 1 96  ? 4.45904   9.87525   -7.15948  1.000 28.29947 ? 448 MET B C   1 
ATOM   2802 O O   . MET B 1 96  ? 4.82131   9.11506   -6.25024  1.000 29.41834 ? 448 MET B O   1 
ATOM   2803 C CB  . MET B 1 96  ? 5.48061   9.53009   -9.41317  1.000 37.96666 ? 448 MET B CB  1 
ATOM   2804 C CG  . MET B 1 96  ? 6.18837   10.13046  -10.61785 1.000 28.73226 ? 448 MET B CG  1 
ATOM   2805 S SD  . MET B 1 96  ? 6.76866   8.85929   -11.74177 1.000 31.63800 ? 448 MET B SD  1 
ATOM   2806 C CE  . MET B 1 96  ? 8.02274   8.05913   -10.74439 1.000 30.09886 ? 448 MET B CE  1 
ATOM   2807 N N   . GLU B 1 97  ? 3.18397   10.21413  -7.35388  1.000 24.89540 ? 449 GLU B N   1 
ATOM   2808 C CA  . GLU B 1 97  ? 2.13131   9.54519   -6.59294  1.000 24.62042 ? 449 GLU B CA  1 
ATOM   2809 C C   . GLU B 1 97  ? 2.18615   8.04728   -6.86391  1.000 24.34824 ? 449 GLU B C   1 
ATOM   2810 O O   . GLU B 1 97  ? 2.23977   7.61985   -8.01660  1.000 28.54484 ? 449 GLU B O   1 
ATOM   2811 C CB  . GLU B 1 97  ? 0.75849   10.10137  -6.96701  1.000 31.47128 ? 449 GLU B CB  1 
ATOM   2812 C CG  . GLU B 1 97  ? -0.42577  9.39191   -6.29242  1.000 31.32299 ? 449 GLU B CG  1 
ATOM   2813 C CD  . GLU B 1 97  ? -1.76575  10.08211  -6.57995  1.000 48.84356 ? 449 GLU B CD  1 
ATOM   2814 O OE1 . GLU B 1 97  ? -1.91211  10.69401  -7.67056  1.000 37.78034 ? 449 GLU B OE1 1 
ATOM   2815 O OE2 . GLU B 1 97  ? -2.66718  10.02227  -5.70712  1.000 45.49188 ? 449 GLU B OE2 1 
ATOM   2816 N N   . MET B 1 98  ? 2.15588   7.25890   -5.79670  1.000 22.71663 ? 450 MET B N   1 
ATOM   2817 C CA  . MET B 1 98  ? 2.28481   5.81350   -5.90310  1.000 23.26302 ? 450 MET B CA  1 
ATOM   2818 C C   . MET B 1 98  ? 1.04347   5.20117   -6.53821  1.000 29.79584 ? 450 MET B C   1 
ATOM   2819 O O   . MET B 1 98  ? -0.08253  5.44434   -6.08918  1.000 29.52480 ? 450 MET B O   1 
ATOM   2820 C CB  . MET B 1 98  ? 2.51295   5.20738   -4.51247  1.000 27.00073 ? 450 MET B CB  1 
ATOM   2821 C CG  . MET B 1 98  ? 2.26498   3.69883   -4.46563  1.000 32.00488 ? 450 MET B CG  1 
ATOM   2822 S SD  . MET B 1 98  ? 3.49331   2.76567   -5.39609  1.000 34.06816 ? 450 MET B SD  1 
ATOM   2823 C CE  . MET B 1 98  ? 4.88464   2.88152   -4.28569  1.000 28.36764 ? 450 MET B CE  1 
ATOM   2824 N N   . ALA B 1 99  ? 1.24973   4.39833   -7.58170  1.000 26.36218 ? 451 ALA B N   1 
ATOM   2825 C CA  . ALA B 1 99  ? 0.21766   3.51848   -8.11786  1.000 29.60932 ? 451 ALA B CA  1 
ATOM   2826 C C   . ALA B 1 99  ? 0.53906   2.12334   -7.59199  1.000 31.77831 ? 451 ALA B C   1 
ATOM   2827 O O   . ALA B 1 99  ? 1.50366   1.48979   -8.03920  1.000 29.29659 ? 451 ALA B O   1 
ATOM   2828 C CB  . ALA B 1 99  ? 0.18455   3.56427   -9.64401  1.000 29.68589 ? 451 ALA B CB  1 
ATOM   2829 N N   . GLU B 1 100 ? -0.27473  1.65456   -6.64055  1.000 30.37607 ? 452 GLU B N   1 
ATOM   2830 C CA  . GLU B 1 100 ? 0.14115   0.59544   -5.72523  1.000 25.79585 ? 452 GLU B CA  1 
ATOM   2831 C C   . GLU B 1 100 ? 0.46237   -0.71954  -6.44152  1.000 34.21875 ? 452 GLU B C   1 
ATOM   2832 O O   . GLU B 1 100 ? 1.42996   -1.40158  -6.08906  1.000 30.91650 ? 452 GLU B O   1 
ATOM   2833 C CB  . GLU B 1 100 ? -0.94333  0.38809   -4.66805  1.000 31.90287 ? 452 GLU B CB  1 
ATOM   2834 C CG  . GLU B 1 100 ? -0.80649  -0.86782  -3.85218  1.000 44.24147 ? 452 GLU B CG  1 
ATOM   2835 C CD  . GLU B 1 100 ? 0.36968   -0.82406  -2.89939  1.000 43.58885 ? 452 GLU B CD  1 
ATOM   2836 O OE1 . GLU B 1 100 ? 0.87325   0.29482   -2.61365  1.000 41.97390 ? 452 GLU B OE1 1 
ATOM   2837 O OE2 . GLU B 1 100 ? 0.77457   -1.91312  -2.42718  1.000 39.30167 ? 452 GLU B OE2 1 
ATOM   2838 N N   . LEU B 1 101 ? -0.32271  -1.09885  -7.44429  1.000 31.52930 ? 453 LEU B N   1 
ATOM   2839 C CA  . LEU B 1 101 ? -0.17462  -2.43987  -8.00379  1.000 32.07106 ? 453 LEU B CA  1 
ATOM   2840 C C   . LEU B 1 101 ? 0.96562   -2.58531  -9.01291  1.000 31.66537 ? 453 LEU B C   1 
ATOM   2841 O O   . LEU B 1 101 ? 1.30136   -3.71534  -9.37734  1.000 34.91621 ? 453 LEU B O   1 
ATOM   2842 C CB  . LEU B 1 101 ? -1.48955  -2.86995  -8.64375  1.000 34.42262 ? 453 LEU B CB  1 
ATOM   2843 C CG  . LEU B 1 101 ? -2.60189  -3.13939  -7.63880  1.000 37.15876 ? 453 LEU B CG  1 
ATOM   2844 C CD1 . LEU B 1 101 ? -3.87573  -3.57292  -8.35159  1.000 37.35335 ? 453 LEU B CD1 1 
ATOM   2845 C CD2 . LEU B 1 101 ? -2.13888  -4.19742  -6.63668  1.000 41.97248 ? 453 LEU B CD2 1 
ATOM   2846 N N   . GLY B 1 102 ? 1.55755   -1.50150  -9.49772  1.000 34.80915 ? 454 GLY B N   1 
ATOM   2847 C CA  . GLY B 1 102 ? 2.73849   -1.60921  -10.33093 1.000 23.15244 ? 454 GLY B CA  1 
ATOM   2848 C C   . GLY B 1 102 ? 2.43393   -1.75035  -11.81488 1.000 28.51112 ? 454 GLY B C   1 
ATOM   2849 O O   . GLY B 1 102 ? 1.28532   -1.62360  -12.25488 1.000 29.73536 ? 454 GLY B O   1 
ATOM   2850 N N   . PRO B 1 103 ? 3.47034   -2.01579  -12.61000 1.000 29.54206 ? 455 PRO B N   1 
ATOM   2851 C CA  . PRO B 1 103 ? 3.30366   -2.08484  -14.07187 1.000 28.03266 ? 455 PRO B CA  1 
ATOM   2852 C C   . PRO B 1 103 ? 2.24954   -3.08563  -14.53041 1.000 32.49209 ? 455 PRO B C   1 
ATOM   2853 O O   . PRO B 1 103 ? 2.03425   -4.14097  -13.92184 1.000 31.02439 ? 455 PRO B O   1 
ATOM   2854 C CB  . PRO B 1 103 ? 4.69365   -2.48934  -14.55994 1.000 28.41187 ? 455 PRO B CB  1 
ATOM   2855 C CG  . PRO B 1 103 ? 5.60817   -1.91224  -13.52154 1.000 29.23514 ? 455 PRO B CG  1 
ATOM   2856 C CD  . PRO B 1 103 ? 4.88595   -2.06044  -12.21549 1.000 30.73808 ? 455 PRO B CD  1 
ATOM   2857 N N   . LEU B 1 104 ? 1.59563   -2.73317  -15.63987 1.000 29.13780 ? 456 LEU B N   1 
ATOM   2858 C CA  . LEU B 1 104 ? 0.48814   -3.53536  -16.14582 1.000 30.28418 ? 456 LEU B CA  1 
ATOM   2859 C C   . LEU B 1 104 ? 0.95274   -4.91680  -16.59616 1.000 30.16498 ? 456 LEU B C   1 
ATOM   2860 O O   . LEU B 1 104 ? 0.25297   -5.90942  -16.37388 1.000 32.83396 ? 456 LEU B O   1 
ATOM   2861 C CB  . LEU B 1 104 ? -0.20821  -2.81161  -17.30411 1.000 29.89971 ? 456 LEU B CB  1 
ATOM   2862 C CG  . LEU B 1 104 ? -1.36836  -3.55727  -17.97537 1.000 30.34264 ? 456 LEU B CG  1 
ATOM   2863 C CD1 . LEU B 1 104 ? -2.45826  -3.90134  -16.95618 1.000 32.05738 ? 456 LEU B CD1 1 
ATOM   2864 C CD2 . LEU B 1 104 ? -1.95588  -2.76843  -19.13054 1.000 35.23179 ? 456 LEU B CD2 1 
ATOM   2865 N N   . ASN B 1 105 ? 2.11718   -5.00907  -17.25176 1.000 29.03060 ? 457 ASN B N   1 
ATOM   2866 C CA  . ASN B 1 105 ? 2.50210   -6.29826  -17.81020 1.000 34.57439 ? 457 ASN B CA  1 
ATOM   2867 C C   . ASN B 1 105 ? 2.82269   -7.29565  -16.70216 1.000 38.89210 ? 457 ASN B C   1 
ATOM   2868 O O   . ASN B 1 105 ? 2.35099   -8.43537  -16.73716 1.000 38.72977 ? 457 ASN B O   1 
ATOM   2869 C CB  . ASN B 1 105 ? 3.67322   -6.15013  -18.77886 1.000 28.62296 ? 457 ASN B CB  1 
ATOM   2870 C CG  . ASN B 1 105 ? 4.88844   -5.53005  -18.14633 1.000 37.73408 ? 457 ASN B CG  1 
ATOM   2871 O OD1 . ASN B 1 105 ? 4.77962   -4.66654  -17.27791 1.000 32.18653 ? 457 ASN B OD1 1 
ATOM   2872 N ND2 . ASN B 1 105 ? 6.06250   -5.94581  -18.60178 1.000 32.04500 ? 457 ASN B ND2 1 
ATOM   2873 N N   . LYS B 1 106 ? 3.60228   -6.87761  -15.69585 1.000 38.19864 ? 458 LYS B N   1 
ATOM   2874 C CA  . LYS B 1 106 ? 3.95143   -7.79175  -14.60670 1.000 34.75393 ? 458 LYS B CA  1 
ATOM   2875 C C   . LYS B 1 106 ? 2.72428   -8.18948  -13.80133 1.000 35.25766 ? 458 LYS B C   1 
ATOM   2876 O O   . LYS B 1 106 ? 2.64168   -9.32558  -13.32220 1.000 44.09265 ? 458 LYS B O   1 
ATOM   2877 C CB  . LYS B 1 106 ? 5.00862   -7.17240  -13.69020 1.000 34.05969 ? 458 LYS B CB  1 
ATOM   2878 C CG  . LYS B 1 106 ? 6.39966   -7.06953  -14.31406 1.000 40.31981 ? 458 LYS B CG  1 
ATOM   2879 C CD  . LYS B 1 106 ? 6.61757   -5.70821  -14.93991 1.000 49.77904 ? 458 LYS B CD  1 
ATOM   2880 C CE  . LYS B 1 106 ? 8.00736   -5.58697  -15.55035 1.000 56.19815 ? 458 LYS B CE  1 
ATOM   2881 N NZ  . LYS B 1 106 ? 8.22807   -4.22196  -16.12499 1.000 60.14240 ? 458 LYS B NZ  1 
ATOM   2882 N N   . TYR B 1 107 ? 1.75964   -7.28543  -13.65908 1.000 34.64838 ? 459 TYR B N   1 
ATOM   2883 C CA  . TYR B 1 107 ? 0.54341   -7.61025  -12.92060 1.000 33.93541 ? 459 TYR B CA  1 
ATOM   2884 C C   . TYR B 1 107 ? -0.26970  -8.69491  -13.62532 1.000 42.80949 ? 459 TYR B C   1 
ATOM   2885 O O   . TYR B 1 107 ? -0.69577  -9.67036  -12.99708 1.000 35.42272 ? 459 TYR B O   1 
ATOM   2886 C CB  . TYR B 1 107 ? -0.30369  -6.36393  -12.71812 1.000 31.49454 ? 459 TYR B CB  1 
ATOM   2887 C CG  . TYR B 1 107 ? -1.48329  -6.64946  -11.83932 1.000 37.37118 ? 459 TYR B CG  1 
ATOM   2888 C CD1 . TYR B 1 107 ? -1.33822  -6.68168  -10.46109 1.000 40.61174 ? 459 TYR B CD1 1 
ATOM   2889 C CD2 . TYR B 1 107 ? -2.72528  -6.93220  -12.37878 1.000 37.61618 ? 459 TYR B CD2 1 
ATOM   2890 C CE1 . TYR B 1 107 ? -2.40276  -6.96279  -9.64418  1.000 32.35520 ? 459 TYR B CE1 1 
ATOM   2891 C CE2 . TYR B 1 107 ? -3.81250  -7.21343  -11.56202 1.000 43.31625 ? 459 TYR B CE2 1 
ATOM   2892 C CZ  . TYR B 1 107 ? -3.63423  -7.22506  -10.19064 1.000 45.28336 ? 459 TYR B CZ  1 
ATOM   2893 O OH  . TYR B 1 107 ? -4.68214  -7.50255  -9.34935  1.000 44.37580 ? 459 TYR B OH  1 
ATOM   2894 N N   . LEU B 1 108 ? -0.50731  -8.54042  -14.93288 1.000 35.90409 ? 460 LEU B N   1 
ATOM   2895 C CA  . LEU B 1 108 ? -1.29733  -9.54504  -15.64431 1.000 40.57268 ? 460 LEU B CA  1 
ATOM   2896 C C   . LEU B 1 108 ? -0.56778  -10.88633 -15.71045 1.000 36.95629 ? 460 LEU B C   1 
ATOM   2897 O O   . LEU B 1 108 ? -1.21224  -11.94211 -15.68343 1.000 41.93536 ? 460 LEU B O   1 
ATOM   2898 C CB  . LEU B 1 108 ? -1.65596  -9.04000  -17.04840 1.000 28.54732 ? 460 LEU B CB  1 
ATOM   2899 C CG  . LEU B 1 108 ? -2.65832  -7.88516  -17.12008 1.000 29.94231 ? 460 LEU B CG  1 
ATOM   2900 C CD1 . LEU B 1 108 ? -2.84858  -7.45633  -18.55781 1.000 30.41234 ? 460 LEU B CD1 1 
ATOM   2901 C CD2 . LEU B 1 108 ? -4.02174  -8.24168  -16.49408 1.000 36.39879 ? 460 LEU B CD2 1 
ATOM   2902 N N   . GLN B 1 109 ? 0.76786   -10.86119 -15.77540 1.000 36.48787 ? 461 GLN B N   1 
ATOM   2903 C CA  . GLN B 1 109 ? 1.55278   -12.09025 -15.74701 1.000 35.34301 ? 461 GLN B CA  1 
ATOM   2904 C C   . GLN B 1 109 ? 1.28989   -12.89690 -14.48240 1.000 49.55990 ? 461 GLN B C   1 
ATOM   2905 O O   . GLN B 1 109 ? 1.28666   -14.13452 -14.52025 1.000 41.30219 ? 461 GLN B O   1 
ATOM   2906 C CB  . GLN B 1 109 ? 3.04342   -11.77117 -15.83628 1.000 32.19959 ? 461 GLN B CB  1 
ATOM   2907 C CG  . GLN B 1 109 ? 3.54045   -11.34864 -17.20354 1.000 42.94994 ? 461 GLN B CG  1 
ATOM   2908 C CD  . GLN B 1 109 ? 4.96010   -10.78815 -17.14942 1.000 52.00503 ? 461 GLN B CD  1 
ATOM   2909 O OE1 . GLN B 1 109 ? 5.66726   -10.94590 -16.14659 1.000 44.69392 ? 461 GLN B OE1 1 
ATOM   2910 N NE2 . GLN B 1 109 ? 5.37263   -10.11078 -18.22184 1.000 49.00384 ? 461 GLN B NE2 1 
ATOM   2911 N N   . GLN B 1 110 ? 1.06518   -12.21970 -13.36013 1.000 42.21701 ? 462 GLN B N   1 
ATOM   2912 C CA  . GLN B 1 110 ? 0.88595   -12.87103 -12.07409 1.000 44.87272 ? 462 GLN B CA  1 
ATOM   2913 C C   . GLN B 1 110 ? -0.57926  -13.00569 -11.69158 1.000 44.83132 ? 462 GLN B C   1 
ATOM   2914 O O   . GLN B 1 110 ? -0.88331  -13.42757 -10.57050 1.000 45.89941 ? 462 GLN B O   1 
ATOM   2915 C CB  . GLN B 1 110 ? 1.65623   -12.10026 -10.99972 1.000 43.08456 ? 462 GLN B CB  1 
ATOM   2916 C CG  . GLN B 1 110 ? 3.16320   -12.16127 -11.18935 1.000 47.80161 ? 462 GLN B CG  1 
ATOM   2917 C CD  . GLN B 1 110 ? 3.88485   -10.90061 -10.72164 1.000 62.34320 ? 462 GLN B CD  1 
ATOM   2918 O OE1 . GLN B 1 110 ? 3.31790   -10.06409 -10.01499 1.000 65.72363 ? 462 GLN B OE1 1 
ATOM   2919 N NE2 . GLN B 1 110 ? 5.14400   -10.75610 -11.12976 1.000 66.91504 ? 462 GLN B NE2 1 
ATOM   2920 N N   . ASN B 1 111 ? -1.48923  -12.67380 -12.59846 1.000 39.73884 ? 463 ASN B N   1 
ATOM   2921 C CA  . ASN B 1 111 ? -2.91716  -12.60220 -12.30145 1.000 43.05632 ? 463 ASN B CA  1 
ATOM   2922 C C   . ASN B 1 111 ? -3.69979  -13.00363 -13.55501 1.000 40.61171 ? 463 ASN B C   1 
ATOM   2923 O O   . ASN B 1 111 ? -4.48404  -12.23349 -14.11495 1.000 44.07234 ? 463 ASN B O   1 
ATOM   2924 C CB  . ASN B 1 111 ? -3.29156  -11.20960 -11.80612 1.000 44.93255 ? 463 ASN B CB  1 
ATOM   2925 C CG  . ASN B 1 111 ? -2.74540  -10.90811 -10.40657 1.000 50.02279 ? 463 ASN B CG  1 
ATOM   2926 O OD1 . ASN B 1 111 ? -3.40111  -11.19428 -9.40694  1.000 43.47819 ? 463 ASN B OD1 1 
ATOM   2927 N ND2 . ASN B 1 111 ? -1.54408  -10.33073 -10.33598 1.000 40.17854 ? 463 ASN B ND2 1 
ATOM   2928 N N   . ARG B 1 112 ? -3.48263  -14.24672 -14.00474 1.000 42.48933 ? 464 ARG B N   1 
ATOM   2929 C CA  . ARG B 1 112 ? -4.12413  -14.75028 -15.21614 1.000 41.61057 ? 464 ARG B CA  1 
ATOM   2930 C C   . ARG B 1 112 ? -5.63691  -14.85040 -15.07552 1.000 47.95221 ? 464 ARG B C   1 
ATOM   2931 O O   . ARG B 1 112 ? -6.33123  -15.00891 -16.08697 1.000 49.26326 ? 464 ARG B O   1 
ATOM   2932 C CB  . ARG B 1 112 ? -3.54524  -16.12046 -15.58175 1.000 45.66991 ? 464 ARG B CB  1 
ATOM   2933 C CG  . ARG B 1 112 ? -2.02013  -16.19432 -15.51254 1.000 44.01386 ? 464 ARG B CG  1 
ATOM   2934 C CD  . ARG B 1 112 ? -1.38359  -16.10081 -16.89547 1.000 57.36909 ? 464 ARG B CD  1 
ATOM   2935 N NE  . ARG B 1 112 ? 0.05045   -15.84226 -16.81843 1.000 48.72930 ? 464 ARG B NE  1 
ATOM   2936 C CZ  . ARG B 1 112 ? 0.99452   -16.77706 -16.82924 1.000 67.42902 ? 464 ARG B CZ  1 
ATOM   2937 N NH1 . ARG B 1 112 ? 0.69687   -18.06677 -16.93434 1.000 47.04542 ? 464 ARG B NH1 1 
ATOM   2938 N NH2 . ARG B 1 112 ? 2.27291   -16.40951 -16.73520 1.000 54.05654 ? 464 ARG B NH2 1 
ATOM   2939 N N   . HIS B 1 113 ? -6.15728  -14.75530 -13.84811 1.000 37.62526 ? 465 HIS B N   1 
ATOM   2940 C CA  . HIS B 1 113 ? -7.59438  -14.82262 -13.60191 1.000 46.85785 ? 465 HIS B CA  1 
ATOM   2941 C C   . HIS B 1 113 ? -8.32084  -13.55579 -14.02520 1.000 50.51758 ? 465 HIS B C   1 
ATOM   2942 O O   . HIS B 1 113 ? -9.55620  -13.57304 -14.11817 1.000 46.93751 ? 465 HIS B O   1 
ATOM   2943 C CB  . HIS B 1 113 ? -7.86493  -15.06931 -12.11103 1.000 52.55725 ? 465 HIS B CB  1 
ATOM   2944 C CG  . HIS B 1 113 ? -7.40939  -13.94676 -11.22442 1.000 51.48514 ? 465 HIS B CG  1 
ATOM   2945 N ND1 . HIS B 1 113 ? -8.23665  -12.90434 -10.85780 1.000 58.38293 ? 465 HIS B ND1 1 
ATOM   2946 C CD2 . HIS B 1 113 ? -6.20565  -13.68787 -10.65549 1.000 44.93083 ? 465 HIS B CD2 1 
ATOM   2947 C CE1 . HIS B 1 113 ? -7.56710  -12.05899 -10.09260 1.000 50.99082 ? 465 HIS B CE1 1 
ATOM   2948 N NE2 . HIS B 1 113 ? -6.33227  -12.51060 -9.95557  1.000 53.37325 ? 465 HIS B NE2 1 
ATOM   2949 N N   . VAL B 1 114 ? -7.59218  -12.45451 -14.25197 1.000 45.21215 ? 466 VAL B N   1 
ATOM   2950 C CA  . VAL B 1 114 ? -8.24044  -11.19894 -14.61126 1.000 43.69586 ? 466 VAL B CA  1 
ATOM   2951 C C   . VAL B 1 114 ? -9.09979  -11.41075 -15.85330 1.000 46.31573 ? 466 VAL B C   1 
ATOM   2952 O O   . VAL B 1 114 ? -8.69263  -12.08471 -16.80956 1.000 41.82756 ? 466 VAL B O   1 
ATOM   2953 C CB  . VAL B 1 114 ? -7.18522  -10.09563 -14.80315 1.000 44.15526 ? 466 VAL B CB  1 
ATOM   2954 C CG1 . VAL B 1 114 ? -7.78641  -8.86215  -15.46948 1.000 42.78740 ? 466 VAL B CG1 1 
ATOM   2955 C CG2 . VAL B 1 114 ? -6.58069  -9.72812  -13.45204 1.000 42.77413 ? 466 VAL B CG2 1 
ATOM   2956 N N   . LYS B 1 115 ? -10.31984 -10.87593 -15.81538 1.000 37.43152 ? 467 LYS B N   1 
ATOM   2957 C CA  . LYS B 1 115 ? -11.34173 -11.13545 -16.81788 1.000 40.04550 ? 467 LYS B CA  1 
ATOM   2958 C C   . LYS B 1 115 ? -11.18762 -10.17306 -18.00166 1.000 38.58268 ? 467 LYS B C   1 
ATOM   2959 O O   . LYS B 1 115 ? -10.60282 -9.10113  -17.88367 1.000 40.20230 ? 467 LYS B O   1 
ATOM   2960 C CB  . LYS B 1 115 ? -12.71752 -11.02628 -16.14793 1.000 48.41525 ? 467 LYS B CB  1 
ATOM   2961 C CG  . LYS B 1 115 ? -13.93371 -10.80477 -17.03783 1.000 60.68394 ? 467 LYS B CG  1 
ATOM   2962 C CD  . LYS B 1 115 ? -14.93974 -9.91098  -16.29948 1.000 65.41527 ? 467 LYS B CD  1 
ATOM   2963 C CE  . LYS B 1 115 ? -16.30976 -10.55729 -16.12824 1.000 57.97986 ? 467 LYS B CE  1 
ATOM   2964 N NZ  . LYS B 1 115 ? -17.19130 -9.70058  -15.26703 1.000 55.86886 ? 467 LYS B NZ  1 
ATOM   2965 N N   . ASP B 1 116 ? -11.69551 -10.58432 -19.16649 1.000 42.11380 ? 468 ASP B N   1 
ATOM   2966 C CA  . ASP B 1 116 ? -11.53950 -9.75618  -20.36076 1.000 45.65287 ? 468 ASP B CA  1 
ATOM   2967 C C   . ASP B 1 116 ? -12.28073 -8.43422  -20.22568 1.000 40.29032 ? 468 ASP B C   1 
ATOM   2968 O O   . ASP B 1 116 ? -11.77067 -7.38718  -20.63587 1.000 37.87798 ? 468 ASP B O   1 
ATOM   2969 C CB  . ASP B 1 116 ? -12.01748 -10.51999 -21.59272 1.000 55.57101 ? 468 ASP B CB  1 
ATOM   2970 C CG  . ASP B 1 116 ? -11.21161 -11.77088 -21.83283 1.000 55.24523 ? 468 ASP B CG  1 
ATOM   2971 O OD1 . ASP B 1 116 ? -9.97488  -11.72848 -21.61881 1.000 62.28865 ? 468 ASP B OD1 1 
ATOM   2972 O OD2 . ASP B 1 116 ? -11.81409 -12.79978 -22.20966 1.000 80.43461 ? 468 ASP B OD2 1 
ATOM   2973 N N   . LYS B 1 117 ? -13.48732 -8.45698  -19.65457 1.000 30.32578 ? 469 LYS B N   1 
ATOM   2974 C CA  . LYS B 1 117 ? -14.18831 -7.20748  -19.38861 1.000 37.39036 ? 469 LYS B CA  1 
ATOM   2975 C C   . LYS B 1 117 ? -13.30918 -6.26461  -18.57544 1.000 35.22185 ? 469 LYS B C   1 
ATOM   2976 O O   . LYS B 1 117 ? -13.27774 -5.05111  -18.82356 1.000 40.13824 ? 469 LYS B O   1 
ATOM   2977 C CB  . LYS B 1 117 ? -15.50384 -7.50377  -18.66143 1.000 32.86646 ? 469 LYS B CB  1 
ATOM   2978 C CG  . LYS B 1 117 ? -16.23454 -6.29898  -18.14211 1.000 42.72996 ? 469 LYS B CG  1 
ATOM   2979 C CD  . LYS B 1 117 ? -17.15314 -6.69197  -16.99008 1.000 50.31337 ? 469 LYS B CD  1 
ATOM   2980 C CE  . LYS B 1 117 ? -17.98061 -5.50466  -16.56538 1.000 56.71451 ? 469 LYS B CE  1 
ATOM   2981 N NZ  . LYS B 1 117 ? -18.45518 -4.77018  -17.77596 1.000 64.90572 ? 469 LYS B NZ  1 
ATOM   2982 N N   . ASN B 1 118 ? -12.56595 -6.82136  -17.62002 1.000 34.09687 ? 470 ASN B N   1 
ATOM   2983 C CA  . ASN B 1 118 ? -11.66054 -6.03988  -16.78261 1.000 35.06330 ? 470 ASN B CA  1 
ATOM   2984 C C   . ASN B 1 118 ? -10.52514 -5.44686  -17.61216 1.000 39.85345 ? 470 ASN B C   1 
ATOM   2985 O O   . ASN B 1 118 ? -10.16704 -4.26749  -17.45910 1.000 38.21815 ? 470 ASN B O   1 
ATOM   2986 C CB  . ASN B 1 118 ? -11.10998 -6.94685  -15.67982 1.000 37.15404 ? 470 ASN B CB  1 
ATOM   2987 C CG  . ASN B 1 118 ? -10.38799 -6.18182  -14.57230 1.000 41.46452 ? 470 ASN B CG  1 
ATOM   2988 O OD1 . ASN B 1 118 ? -9.97075  -5.03566  -14.75030 1.000 38.03575 ? 470 ASN B OD1 1 
ATOM   2989 N ND2 . ASN B 1 118 ? -10.23656 -6.82508  -13.41776 1.000 31.98566 ? 470 ASN B ND2 1 
ATOM   2990 N N   . ILE B 1 119 ? -9.94600  -6.25556  -18.49152 1.000 28.13402 ? 471 ILE B N   1 
ATOM   2991 C CA  . ILE B 1 119 ? -8.87038  -5.78070  -19.35237 1.000 35.53901 ? 471 ILE B CA  1 
ATOM   2992 C C   . ILE B 1 119 ? -9.38176  -4.70857  -20.30387 1.000 35.04040 ? 471 ILE B C   1 
ATOM   2993 O O   . ILE B 1 119 ? -8.71194  -3.69259  -20.52029 1.000 33.19315 ? 471 ILE B O   1 
ATOM   2994 C CB  . ILE B 1 119 ? -8.23302  -6.96650  -20.09861 1.000 32.67355 ? 471 ILE B CB  1 
ATOM   2995 C CG1 . ILE B 1 119 ? -7.69470  -7.97760  -19.08290 1.000 31.45229 ? 471 ILE B CG1 1 
ATOM   2996 C CG2 . ILE B 1 119 ? -7.09737  -6.47983  -21.00559 1.000 40.31140 ? 471 ILE B CG2 1 
ATOM   2997 C CD1 . ILE B 1 119 ? -7.08663  -9.20592  -19.70059 1.000 34.86059 ? 471 ILE B CD1 1 
ATOM   2998 N N   . ILE B 1 120 ? -10.58635 -4.89688  -20.86531 1.000 31.77339 ? 472 ILE B N   1 
ATOM   2999 C CA  . ILE B 1 120 ? -11.19107 -3.85697  -21.70162 1.000 33.32230 ? 472 ILE B CA  1 
ATOM   3000 C C   . ILE B 1 120 ? -11.25814 -2.53744  -20.94140 1.000 30.22954 ? 472 ILE B C   1 
ATOM   3001 O O   . ILE B 1 120 ? -10.90416 -1.47139  -21.45973 1.000 31.00713 ? 472 ILE B O   1 
ATOM   3002 C CB  . ILE B 1 120 ? -12.59030 -4.29210  -22.18116 1.000 30.10847 ? 472 ILE B CB  1 
ATOM   3003 C CG1 . ILE B 1 120 ? -12.50087 -5.54623  -23.04120 1.000 33.95635 ? 472 ILE B CG1 1 
ATOM   3004 C CG2 . ILE B 1 120 ? -13.25321 -3.16735  -22.96375 1.000 34.05381 ? 472 ILE B CG2 1 
ATOM   3005 C CD1 . ILE B 1 120 ? -13.83201 -6.01971  -23.53542 1.000 34.81384 ? 472 ILE B CD1 1 
ATOM   3006 N N   . GLU B 1 121 ? -11.71286 -2.59536  -19.69232 1.000 30.06372 ? 473 GLU B N   1 
ATOM   3007 C CA  . GLU B 1 121 ? -11.79145 -1.40082  -18.86286 1.000 39.29644 ? 473 GLU B CA  1 
ATOM   3008 C C   . GLU B 1 121 ? -10.42205 -0.74703  -18.70075 1.000 33.17951 ? 473 GLU B C   1 
ATOM   3009 O O   . GLU B 1 121 ? -10.29778 0.48696   -18.77374 1.000 31.65618 ? 473 GLU B O   1 
ATOM   3010 C CB  . GLU B 1 121 ? -12.38045 -1.77232  -17.50167 1.000 35.10892 ? 473 GLU B CB  1 
ATOM   3011 C CG  . GLU B 1 121 ? -12.35531 -0.66357  -16.47367 1.000 39.53178 ? 473 GLU B CG  1 
ATOM   3012 C CD  . GLU B 1 121 ? -12.89424 -1.12373  -15.13142 1.000 50.88680 ? 473 GLU B CD  1 
ATOM   3013 O OE1 . GLU B 1 121 ? -12.48124 -2.21383  -14.65785 1.000 43.73886 ? 473 GLU B OE1 1 
ATOM   3014 O OE2 . GLU B 1 121 ? -13.74794 -0.40261  -14.56767 1.000 49.70804 ? 473 GLU B OE2 1 
ATOM   3015 N N   . LEU B 1 122 ? -9.38170  -1.55675  -18.50173 1.000 26.75388 ? 474 LEU B N   1 
ATOM   3016 C CA  . LEU B 1 122 ? -8.05682  -0.98780  -18.25195 1.000 34.67813 ? 474 LEU B CA  1 
ATOM   3017 C C   . LEU B 1 122 ? -7.47864  -0.34174  -19.50530 1.000 30.53813 ? 474 LEU B C   1 
ATOM   3018 O O   . LEU B 1 122 ? -6.92030  0.75455   -19.42856 1.000 25.54184 ? 474 LEU B O   1 
ATOM   3019 C CB  . LEU B 1 122 ? -7.10723  -2.05175  -17.71515 1.000 29.04676 ? 474 LEU B CB  1 
ATOM   3020 C CG  . LEU B 1 122 ? -7.43479  -2.56769  -16.31529 1.000 32.92956 ? 474 LEU B CG  1 
ATOM   3021 C CD1 . LEU B 1 122 ? -6.46017  -3.67993  -15.94617 1.000 31.93792 ? 474 LEU B CD1 1 
ATOM   3022 C CD2 . LEU B 1 122 ? -7.40147  -1.42241  -15.30228 1.000 30.04349 ? 474 LEU B CD2 1 
ATOM   3023 N N   . VAL B 1 123 ? -7.61382  -0.98571  -20.67191 1.000 29.58374 ? 475 VAL B N   1 
ATOM   3024 C CA  . VAL B 1 123 ? -7.05562  -0.36191  -21.87431 1.000 31.27292 ? 475 VAL B CA  1 
ATOM   3025 C C   . VAL B 1 123 ? -7.90334  0.81983   -22.31061 1.000 32.93357 ? 475 VAL B C   1 
ATOM   3026 O O   . VAL B 1 123 ? -7.38991  1.75601   -22.93705 1.000 28.91676 ? 475 VAL B O   1 
ATOM   3027 C CB  . VAL B 1 123 ? -6.88456  -1.37216  -23.02641 1.000 29.92448 ? 475 VAL B CB  1 
ATOM   3028 C CG1 . VAL B 1 123 ? -5.90097  -2.46507  -22.63693 1.000 38.89128 ? 475 VAL B CG1 1 
ATOM   3029 C CG2 . VAL B 1 123 ? -8.21927  -1.95068  -23.45743 1.000 29.31668 ? 475 VAL B CG2 1 
ATOM   3030 N N   . HIS B 1 124 ? -9.20730  0.81207   -21.99309 1.000 28.33435 ? 476 HIS B N   1 
ATOM   3031 C CA  . HIS B 1 124 ? -10.02380 1.98672   -22.28366 1.000 29.63495 ? 476 HIS B CA  1 
ATOM   3032 C C   . HIS B 1 124 ? -9.56336  3.18355   -21.46503 1.000 28.39175 ? 476 HIS B C   1 
ATOM   3033 O O   . HIS B 1 124 ? -9.55400  4.31293   -21.96220 1.000 34.38616 ? 476 HIS B O   1 
ATOM   3034 C CB  . HIS B 1 124 ? -11.51722 1.71248   -22.03377 1.000 35.55273 ? 476 HIS B CB  1 
ATOM   3035 C CG  . HIS B 1 124 ? -12.37181 2.94003   -22.14471 1.000 30.66712 ? 476 HIS B CG  1 
ATOM   3036 N ND1 . HIS B 1 124 ? -13.11424 3.43232   -21.09355 1.000 33.26785 ? 476 HIS B ND1 1 
ATOM   3037 C CD2 . HIS B 1 124 ? -12.55168 3.80796   -23.16833 1.000 30.87687 ? 476 HIS B CD2 1 
ATOM   3038 C CE1 . HIS B 1 124 ? -13.72806 4.54052   -21.47034 1.000 30.89461 ? 476 HIS B CE1 1 
ATOM   3039 N NE2 . HIS B 1 124 ? -13.41152 4.78654   -22.72820 1.000 30.87798 ? 476 HIS B NE2 1 
ATOM   3040 N N   . GLN B 1 125 ? -9.16219  2.96116   -20.21046 1.000 34.33734 ? 477 GLN B N   1 
ATOM   3041 C CA  . GLN B 1 125 ? -8.63973  4.07126   -19.41243 1.000 33.83864 ? 477 GLN B CA  1 
ATOM   3042 C C   . GLN B 1 125 ? -7.32964  4.59980   -19.99178 1.000 27.90783 ? 477 GLN B C   1 
ATOM   3043 O O   . GLN B 1 125 ? -7.09686  5.81831   -20.00570 1.000 25.24510 ? 477 GLN B O   1 
ATOM   3044 C CB  . GLN B 1 125 ? -8.45641  3.63996   -17.95524 1.000 32.83368 ? 477 GLN B CB  1 
ATOM   3045 C CG  . GLN B 1 125 ? -9.77649  3.55298   -17.18574 1.000 39.27016 ? 477 GLN B CG  1 
ATOM   3046 C CD  . GLN B 1 125 ? -9.67563  2.72687   -15.91116 1.000 39.37143 ? 477 GLN B CD  1 
ATOM   3047 O OE1 . GLN B 1 125 ? -8.65449  2.08017   -15.65151 1.000 36.87939 ? 477 GLN B OE1 1 
ATOM   3048 N NE2 . GLN B 1 125 ? -10.74286 2.74714   -15.10646 1.000 36.33372 ? 477 GLN B NE2 1 
ATOM   3049 N N   . VAL B 1 126 ? -6.46840  3.70274   -20.47779 1.000 25.85991 ? 478 VAL B N   1 
ATOM   3050 C CA  . VAL B 1 126 ? -5.26885  4.15506   -21.18292 1.000 25.54852 ? 478 VAL B CA  1 
ATOM   3051 C C   . VAL B 1 126 ? -5.65942  4.99420   -22.39737 1.000 24.50847 ? 478 VAL B C   1 
ATOM   3052 O O   . VAL B 1 126 ? -5.09103  6.06387   -22.62831 1.000 25.20177 ? 478 VAL B O   1 
ATOM   3053 C CB  . VAL B 1 126 ? -4.38395  2.95663   -21.57542 1.000 24.87055 ? 478 VAL B CB  1 
ATOM   3054 C CG1 . VAL B 1 126 ? -3.17119  3.43978   -22.36312 1.000 24.16462 ? 478 VAL B CG1 1 
ATOM   3055 C CG2 . VAL B 1 126 ? -3.92109  2.20437   -20.34280 1.000 28.24574 ? 478 VAL B CG2 1 
ATOM   3056 N N   . SER B 1 127 ? -6.69514  4.56730   -23.15133 1.000 26.62294 ? 479 SER B N   1 
ATOM   3057 C CA  . SER B 1 127 ? -7.07792  5.34234   -24.32808 1.000 25.47921 ? 479 SER B CA  1 
ATOM   3058 C C   . SER B 1 127 ? -7.60574  6.71767   -23.94071 1.000 26.09180 ? 479 SER B C   1 
ATOM   3059 O O   . SER B 1 127 ? -7.44671  7.67504   -24.70440 1.000 30.15901 ? 479 SER B O   1 
ATOM   3060 C CB  . SER B 1 127 ? -8.09809  4.58443   -25.18650 1.000 31.00863 ? 479 SER B CB  1 
ATOM   3061 O OG  . SER B 1 127 ? -9.41651  4.69416   -24.67776 1.000 29.49666 ? 479 SER B OG  1 
ATOM   3062 N N   . MET B 1 128 ? -8.21752  6.84316   -22.75929 1.000 32.16762 ? 480 MET B N   1 
ATOM   3063 C CA  . MET B 1 128 ? -8.65920  8.15962   -22.30479 1.000 31.67266 ? 480 MET B CA  1 
ATOM   3064 C C   . MET B 1 128 ? -7.47563  9.03479   -21.90218 1.000 24.83364 ? 480 MET B C   1 
ATOM   3065 O O   . MET B 1 128 ? -7.43905  10.23013  -22.22106 1.000 28.04671 ? 480 MET B O   1 
ATOM   3066 C CB  . MET B 1 128 ? -9.64118  8.01313   -21.13947 1.000 29.94712 ? 480 MET B CB  1 
ATOM   3067 C CG  . MET B 1 128 ? -11.00687 7.46525   -21.55564 1.000 29.54972 ? 480 MET B CG  1 
ATOM   3068 S SD  . MET B 1 128 ? -12.19650 7.56465   -20.18994 1.000 36.57660 ? 480 MET B SD  1 
ATOM   3069 C CE  . MET B 1 128 ? -11.83384 6.08220   -19.27166 1.000 28.65120 ? 480 MET B CE  1 
ATOM   3070 N N   . GLY B 1 129 ? -6.50464  8.47715   -21.18755 1.000 27.57418 ? 481 GLY B N   1 
ATOM   3071 C CA  . GLY B 1 129 ? -5.27992  9.23184   -20.95506 1.000 26.31667 ? 481 GLY B CA  1 
ATOM   3072 C C   . GLY B 1 129 ? -4.62881  9.68696   -22.24606 1.000 26.47578 ? 481 GLY B C   1 
ATOM   3073 O O   . GLY B 1 129 ? -4.21053  10.84290  -22.36767 1.000 31.07882 ? 481 GLY B O   1 
ATOM   3074 N N   . MET B 1 130 ? -4.55918  8.79073   -23.24501 1.000 30.22450 ? 482 MET B N   1 
ATOM   3075 C CA  . MET B 1 130 ? -3.91461  9.13700   -24.51899 1.000 24.75145 ? 482 MET B CA  1 
ATOM   3076 C C   . MET B 1 130 ? -4.74657  10.11524  -25.34448 1.000 29.49249 ? 482 MET B C   1 
ATOM   3077 O O   . MET B 1 130 ? -4.18944  10.92731  -26.10375 1.000 26.32167 ? 482 MET B O   1 
ATOM   3078 C CB  . MET B 1 130 ? -3.63006  7.87469   -25.33632 1.000 28.44331 ? 482 MET B CB  1 
ATOM   3079 C CG  . MET B 1 130 ? -2.58718  6.97561   -24.72919 1.000 27.55851 ? 482 MET B CG  1 
ATOM   3080 S SD  . MET B 1 130 ? -0.98911  7.80578   -24.48362 1.000 28.69730 ? 482 MET B SD  1 
ATOM   3081 C CE  . MET B 1 130 ? -0.79871  8.54878   -26.09899 1.000 27.79785 ? 482 MET B CE  1 
ATOM   3082 N N   . LYS B 1 131 ? -6.07465  10.04683  -25.24325 1.000 32.98687 ? 483 LYS B N   1 
ATOM   3083 C CA  . LYS B 1 131 ? -6.88998  11.06777  -25.89686 1.000 26.38347 ? 483 LYS B CA  1 
ATOM   3084 C C   . LYS B 1 131 ? -6.57981  12.44273  -25.31740 1.000 25.10016 ? 483 LYS B C   1 
ATOM   3085 O O   . LYS B 1 131 ? -6.44931  13.42148  -26.06022 1.000 30.30945 ? 483 LYS B O   1 
ATOM   3086 C CB  . LYS B 1 131 ? -8.37754  10.71343  -25.74682 1.000 30.47941 ? 483 LYS B CB  1 
ATOM   3087 C CG  . LYS B 1 131 ? -9.35242  11.59745  -26.50336 1.000 35.35999 ? 483 LYS B CG  1 
ATOM   3088 C CD  . LYS B 1 131 ? -10.78468 11.11973  -26.19045 1.000 40.36206 ? 483 LYS B CD  1 
ATOM   3089 C CE  . LYS B 1 131 ? -11.81058 12.22836  -26.32245 1.000 53.16133 ? 483 LYS B CE  1 
ATOM   3090 N NZ  . LYS B 1 131 ? -13.18274 11.67066  -26.11221 1.000 44.28102 ? 483 LYS B NZ  1 
ATOM   3091 N N   . TYR B 1 132 ? -6.38570  12.51431  -23.99576 1.000 26.22557 ? 484 TYR B N   1 
ATOM   3092 C CA  . TYR B 1 132 ? -5.97658  13.75997  -23.35204 1.000 30.74853 ? 484 TYR B CA  1 
ATOM   3093 C C   . TYR B 1 132 ? -4.60767  14.22101  -23.84736 1.000 34.54310 ? 484 TYR B C   1 
ATOM   3094 O O   . TYR B 1 132 ? -4.41245  15.40379  -24.16173 1.000 31.17396 ? 484 TYR B O   1 
ATOM   3095 C CB  . TYR B 1 132 ? -5.97396  13.57988  -21.83203 1.000 34.51912 ? 484 TYR B CB  1 
ATOM   3096 C CG  . TYR B 1 132 ? -5.27181  14.69999  -21.08913 1.000 35.53718 ? 484 TYR B CG  1 
ATOM   3097 C CD1 . TYR B 1 132 ? -5.89664  15.92132  -20.88046 1.000 40.01632 ? 484 TYR B CD1 1 
ATOM   3098 C CD2 . TYR B 1 132 ? -3.98139  14.52985  -20.60169 1.000 29.91041 ? 484 TYR B CD2 1 
ATOM   3099 C CE1 . TYR B 1 132 ? -5.25674  16.94207  -20.20045 1.000 34.63206 ? 484 TYR B CE1 1 
ATOM   3100 C CE2 . TYR B 1 132 ? -3.33438  15.53476  -19.93410 1.000 32.12422 ? 484 TYR B CE2 1 
ATOM   3101 C CZ  . TYR B 1 132 ? -3.96973  16.74187  -19.73723 1.000 38.27911 ? 484 TYR B CZ  1 
ATOM   3102 O OH  . TYR B 1 132 ? -3.32103  17.74154  -19.06019 1.000 39.60835 ? 484 TYR B OH  1 
ATOM   3103 N N   . LEU B 1 133 ? -3.63586  13.30051  -23.91476 1.000 30.85942 ? 485 LEU B N   1 
ATOM   3104 C CA  . LEU B 1 133 ? -2.32109  13.65106  -24.45282 1.000 26.77358 ? 485 LEU B CA  1 
ATOM   3105 C C   . LEU B 1 133 ? -2.42797  14.12388  -25.89257 1.000 27.65612 ? 485 LEU B C   1 
ATOM   3106 O O   . LEU B 1 133 ? -1.78119  15.10496  -26.28457 1.000 30.40318 ? 485 LEU B O   1 
ATOM   3107 C CB  . LEU B 1 133 ? -1.37039  12.45406  -24.37953 1.000 25.55373 ? 485 LEU B CB  1 
ATOM   3108 C CG  . LEU B 1 133 ? -0.58588  12.19206  -23.09992 1.000 33.73515 ? 485 LEU B CG  1 
ATOM   3109 C CD1 . LEU B 1 133 ? 0.44118   11.07855  -23.35191 1.000 34.09216 ? 485 LEU B CD1 1 
ATOM   3110 C CD2 . LEU B 1 133 ? 0.11520   13.45346  -22.64421 1.000 37.57204 ? 485 LEU B CD2 1 
ATOM   3111 N N   . GLU B 1 134 ? -3.23677  13.42716  -26.69296 1.000 23.76490 ? 486 GLU B N   1 
ATOM   3112 C CA  . GLU B 1 134 ? -3.44491  13.80266  -28.08680 1.000 30.49736 ? 486 GLU B CA  1 
ATOM   3113 C C   . GLU B 1 134 ? -4.03417  15.21117  -28.20662 1.000 30.00132 ? 486 GLU B C   1 
ATOM   3114 O O   . GLU B 1 134 ? -3.51477  16.05125  -28.95074 1.000 32.79971 ? 486 GLU B O   1 
ATOM   3115 C CB  . GLU B 1 134 ? -4.36253  12.77951  -28.75630 1.000 30.20920 ? 486 GLU B CB  1 
ATOM   3116 C CG  . GLU B 1 134 ? -4.62995  13.01608  -30.23167 1.000 31.03374 ? 486 GLU B CG  1 
ATOM   3117 C CD  . GLU B 1 134 ? -5.49887  11.92078  -30.83169 1.000 41.32689 ? 486 GLU B CD  1 
ATOM   3118 O OE1 . GLU B 1 134 ? -6.72970  11.93889  -30.60243 1.000 43.33740 ? 486 GLU B OE1 1 
ATOM   3119 O OE2 . GLU B 1 134 ? -4.95084  11.01719  -31.50360 1.000 37.01140 ? 486 GLU B OE2 1 
ATOM   3120 N N   . GLU B 1 135 ? -5.14398  15.47796  -27.50948 1.000 35.19886 ? 487 GLU B N   1 
ATOM   3121 C CA  . GLU B 1 135 ? -5.73368  16.81550  -27.57982 1.000 36.36012 ? 487 GLU B CA  1 
ATOM   3122 C C   . GLU B 1 135 ? -4.77774  17.86659  -27.03417 1.000 37.51297 ? 487 GLU B C   1 
ATOM   3123 O O   . GLU B 1 135 ? -4.82526  19.02958  -27.44923 1.000 36.68415 ? 487 GLU B O   1 
ATOM   3124 C CB  . GLU B 1 135 ? -7.06048  16.85204  -26.82457 1.000 36.15924 ? 487 GLU B CB  1 
ATOM   3125 C CG  . GLU B 1 135 ? -6.94422  16.38690  -25.39735 1.000 48.67193 ? 487 GLU B CG  1 
ATOM   3126 C CD  . GLU B 1 135 ? -8.08739  16.83107  -24.49960 1.000 65.09672 ? 487 GLU B CD  1 
ATOM   3127 O OE1 . GLU B 1 135 ? -8.16124  18.04252  -24.16384 1.000 62.92679 ? 487 GLU B OE1 1 
ATOM   3128 O OE2 . GLU B 1 135 ? -8.89465  15.95372  -24.11208 1.000 68.70606 ? 487 GLU B OE2 1 
ATOM   3129 N N   . SER B 1 136 ? -3.90559  17.47483  -26.10723 1.000 33.68965 ? 488 SER B N   1 
ATOM   3130 C CA  . SER B 1 136 ? -2.83851  18.32003  -25.59783 1.000 31.19721 ? 488 SER B CA  1 
ATOM   3131 C C   . SER B 1 136 ? -1.66467  18.43497  -26.55129 1.000 33.85877 ? 488 SER B C   1 
ATOM   3132 O O   . SER B 1 136 ? -0.74538  19.20444  -26.26968 1.000 31.59297 ? 488 SER B O   1 
ATOM   3133 C CB  . SER B 1 136 ? -2.31765  17.77949  -24.26461 1.000 33.68554 ? 488 SER B CB  1 
ATOM   3134 O OG  . SER B 1 136 ? -3.33345  17.76575  -23.28741 1.000 32.47597 ? 488 SER B OG  1 
ATOM   3135 N N   . ASN B 1 137 ? -1.66018  17.66650  -27.63968 1.000 35.53550 ? 489 ASN B N   1 
ATOM   3136 C CA  . ASN B 1 137 ? -0.57248  17.67138  -28.61777 1.000 33.32638 ? 489 ASN B CA  1 
ATOM   3137 C C   . ASN B 1 137 ? 0.77459   17.34544  -27.97565 1.000 31.55718 ? 489 ASN B C   1 
ATOM   3138 O O   . ASN B 1 137 ? 1.78889   17.99396  -28.25076 1.000 31.61342 ? 489 ASN B O   1 
ATOM   3139 C CB  . ASN B 1 137 ? -0.52186  19.00187  -29.37509 1.000 41.91916 ? 489 ASN B CB  1 
ATOM   3140 C CG  . ASN B 1 137 ? -1.70947  19.17514  -30.30465 1.000 42.57518 ? 489 ASN B CG  1 
ATOM   3141 O OD1 . ASN B 1 137 ? -2.11038  18.23482  -30.99950 1.000 47.88842 ? 489 ASN B OD1 1 
ATOM   3142 N ND2 . ASN B 1 137 ? -2.28592  20.36590  -30.31263 1.000 50.65930 ? 489 ASN B ND2 1 
ATOM   3143 N N   . PHE B 1 138 ? 0.78517   16.32053  -27.11947 1.000 29.90842 ? 490 PHE B N   1 
ATOM   3144 C CA  . PHE B 1 138 ? 2.01236   15.65508  -26.70006 1.000 32.95216 ? 490 PHE B CA  1 
ATOM   3145 C C   . PHE B 1 138 ? 2.04148   14.27313  -27.34104 1.000 28.32663 ? 490 PHE B C   1 
ATOM   3146 O O   . PHE B 1 138 ? 1.00067   13.62262  -27.45916 1.000 29.17215 ? 490 PHE B O   1 
ATOM   3147 C CB  . PHE B 1 138 ? 2.08313   15.50322  -25.17657 1.000 26.13903 ? 490 PHE B CB  1 
ATOM   3148 C CG  . PHE B 1 138 ? 2.53677   16.74510  -24.43596 1.000 33.81739 ? 490 PHE B CG  1 
ATOM   3149 C CD1 . PHE B 1 138 ? 1.63023   17.72082  -24.06311 1.000 35.55164 ? 490 PHE B CD1 1 
ATOM   3150 C CD2 . PHE B 1 138 ? 3.85897   16.88954  -24.05114 1.000 33.39601 ? 490 PHE B CD2 1 
ATOM   3151 C CE1 . PHE B 1 138 ? 2.04392   18.84262  -23.36055 1.000 36.16985 ? 490 PHE B CE1 1 
ATOM   3152 C CE2 . PHE B 1 138 ? 4.27773   17.99970  -23.34822 1.000 36.87741 ? 490 PHE B CE2 1 
ATOM   3153 C CZ  . PHE B 1 138 ? 3.37105   18.97686  -22.99902 1.000 32.65324 ? 490 PHE B CZ  1 
ATOM   3154 N N   . VAL B 1 139 ? 3.21085   13.82984  -27.78649 1.000 22.80115 ? 491 VAL B N   1 
ATOM   3155 C CA  . VAL B 1 139 ? 3.37398   12.43427  -28.20137 1.000 24.40914 ? 491 VAL B CA  1 
ATOM   3156 C C   . VAL B 1 139 ? 4.09782   11.68672  -27.09319 1.000 27.23465 ? 491 VAL B C   1 
ATOM   3157 O O   . VAL B 1 139 ? 5.09397   12.17629  -26.56088 1.000 27.22282 ? 491 VAL B O   1 
ATOM   3158 C CB  . VAL B 1 139 ? 4.11790   12.31508  -29.54330 1.000 24.90782 ? 491 VAL B CB  1 
ATOM   3159 C CG1 . VAL B 1 139 ? 3.18298   12.72867  -30.66118 1.000 34.12983 ? 491 VAL B CG1 1 
ATOM   3160 C CG2 . VAL B 1 139 ? 5.40393   13.15274  -29.58366 1.000 26.22518 ? 491 VAL B CG2 1 
ATOM   3161 N N   . HIS B 1 140 ? 3.61614   10.48867  -26.76039 1.000 30.71973 ? 492 HIS B N   1 
ATOM   3162 C CA  . HIS B 1 140 ? 4.23918   9.72758   -25.68026 1.000 26.30680 ? 492 HIS B CA  1 
ATOM   3163 C C   . HIS B 1 140 ? 5.56499   9.11144   -26.12263 1.000 27.38358 ? 492 HIS B C   1 
ATOM   3164 O O   . HIS B 1 140 ? 6.58867   9.26484   -25.44354 1.000 31.06966 ? 492 HIS B O   1 
ATOM   3165 C CB  . HIS B 1 140 ? 3.29298   8.63996   -25.19069 1.000 24.40508 ? 492 HIS B CB  1 
ATOM   3166 C CG  . HIS B 1 140 ? 3.75366   7.98330   -23.92594 1.000 26.93069 ? 492 HIS B CG  1 
ATOM   3167 N ND1 . HIS B 1 140 ? 4.68399   6.96407   -23.91434 1.000 33.20612 ? 492 HIS B ND1 1 
ATOM   3168 C CD2 . HIS B 1 140 ? 3.43523   8.21709   -22.63332 1.000 27.91443 ? 492 HIS B CD2 1 
ATOM   3169 C CE1 . HIS B 1 140 ? 4.90703   6.58885   -22.66593 1.000 37.06903 ? 492 HIS B CE1 1 
ATOM   3170 N NE2 . HIS B 1 140 ? 4.15986   7.33334   -21.86665 1.000 29.29159 ? 492 HIS B NE2 1 
ATOM   3171 N N   . ARG B 1 141 ? 5.53984   8.36685   -27.23072 1.000 32.08478 ? 493 ARG B N   1 
ATOM   3172 C CA  . ARG B 1 141 ? 6.66763   7.71665   -27.89706 1.000 28.01471 ? 493 ARG B CA  1 
ATOM   3173 C C   . ARG B 1 141 ? 7.20301   6.50045   -27.15577 1.000 31.99960 ? 493 ARG B C   1 
ATOM   3174 O O   . ARG B 1 141 ? 8.19744   5.91115   -27.59632 1.000 32.22464 ? 493 ARG B O   1 
ATOM   3175 C CB  . ARG B 1 141 ? 7.80995   8.69821   -28.17587 1.000 27.46613 ? 493 ARG B CB  1 
ATOM   3176 C CG  . ARG B 1 141 ? 7.36607   9.83234   -29.09988 1.000 27.14032 ? 493 ARG B CG  1 
ATOM   3177 C CD  . ARG B 1 141 ? 8.50323   10.74988  -29.46301 1.000 34.80065 ? 493 ARG B CD  1 
ATOM   3178 N NE  . ARG B 1 141 ? 9.59578   10.04538  -30.11725 1.000 41.85919 ? 493 ARG B NE  1 
ATOM   3179 C CZ  . ARG B 1 141 ? 10.85961  10.10358  -29.72476 1.000 35.99187 ? 493 ARG B CZ  1 
ATOM   3180 N NH1 . ARG B 1 141 ? 11.22040  10.79468  -28.65615 1.000 36.70006 ? 493 ARG B NH1 1 
ATOM   3181 N NH2 . ARG B 1 141 ? 11.78642  9.46612   -30.43120 1.000 41.55908 ? 493 ARG B NH2 1 
ATOM   3182 N N   . ASP B 1 142 ? 6.55987   6.07437   -26.07578 1.000 26.42344 ? 494 ASP B N   1 
ATOM   3183 C CA  . ASP B 1 142 ? 6.95549   4.83592   -25.40359 1.000 29.90526 ? 494 ASP B CA  1 
ATOM   3184 C C   . ASP B 1 142 ? 5.72917   4.17780   -24.78047 1.000 27.15498 ? 494 ASP B C   1 
ATOM   3185 O O   . ASP B 1 142 ? 5.73024   3.77671   -23.61415 1.000 30.04006 ? 494 ASP B O   1 
ATOM   3186 C CB  . ASP B 1 142 ? 8.02754   5.12028   -24.35222 1.000 25.98484 ? 494 ASP B CB  1 
ATOM   3187 C CG  . ASP B 1 142 ? 8.82259   3.88750   -23.97932 1.000 35.29304 ? 494 ASP B CG  1 
ATOM   3188 O OD1 . ASP B 1 142 ? 8.67928   2.83719   -24.64884 1.000 38.58551 ? 494 ASP B OD1 1 
ATOM   3189 O OD2 . ASP B 1 142 ? 9.60007   3.97095   -23.00362 1.000 34.91736 ? 494 ASP B OD2 1 
ATOM   3190 N N   . LEU B 1 143 ? 4.64487   4.06985   -25.54725 1.000 26.34595 ? 495 LEU B N   1 
ATOM   3191 C CA  . LEU B 1 143 ? 3.39502   3.53993   -25.00192 1.000 28.04864 ? 495 LEU B CA  1 
ATOM   3192 C C   . LEU B 1 143 ? 3.40972   2.01220   -25.07049 1.000 26.38837 ? 495 LEU B C   1 
ATOM   3193 O O   . LEU B 1 143 ? 3.08151   1.41579   -26.09624 1.000 33.00092 ? 495 LEU B O   1 
ATOM   3194 C CB  . LEU B 1 143 ? 2.20099   4.12309   -25.75191 1.000 29.56912 ? 495 LEU B CB  1 
ATOM   3195 C CG  . LEU B 1 143 ? 0.80306   3.68733   -25.27410 1.000 29.57682 ? 495 LEU B CG  1 
ATOM   3196 C CD1 . LEU B 1 143 ? 0.54096   4.02700   -23.79128 1.000 28.81247 ? 495 LEU B CD1 1 
ATOM   3197 C CD2 . LEU B 1 143 ? -0.22497  4.32496   -26.16310 1.000 24.56132 ? 495 LEU B CD2 1 
ATOM   3198 N N   . ALA B 1 144 ? 3.74313   1.37142   -23.95769 1.000 25.36579 ? 496 ALA B N   1 
ATOM   3199 C CA  . ALA B 1 144 ? 3.79579   -0.08126  -23.88243 1.000 30.46659 ? 496 ALA B CA  1 
ATOM   3200 C C   . ALA B 1 144 ? 3.16510   -0.49561  -22.55828 1.000 33.82982 ? 496 ALA B C   1 
ATOM   3201 O O   . ALA B 1 144 ? 2.98364   0.32834   -21.66249 1.000 25.86059 ? 496 ALA B O   1 
ATOM   3202 C CB  . ALA B 1 144 ? 5.24154   -0.59790  -23.99977 1.000 24.05785 ? 496 ALA B CB  1 
ATOM   3203 N N   . ALA B 1 145 ? 2.80283   -1.77849  -22.44657 1.000 25.23031 ? 497 ALA B N   1 
ATOM   3204 C CA  . ALA B 1 145 ? 2.13966   -2.24143  -21.22992 1.000 22.40323 ? 497 ALA B CA  1 
ATOM   3205 C C   . ALA B 1 145 ? 2.98278   -1.97262  -19.98881 1.000 28.33197 ? 497 ALA B C   1 
ATOM   3206 O O   . ALA B 1 145 ? 2.43498   -1.72456  -18.91098 1.000 31.06259 ? 497 ALA B O   1 
ATOM   3207 C CB  . ALA B 1 145 ? 1.82063   -3.73269  -21.35120 1.000 28.74146 ? 497 ALA B CB  1 
ATOM   3208 N N   . ARG B 1 146 ? 4.31159   -2.02034  -20.11394 1.000 23.92004 ? 498 ARG B N   1 
ATOM   3209 C CA  . ARG B 1 146 ? 5.18080   -1.81224  -18.95304 1.000 29.64029 ? 498 ARG B CA  1 
ATOM   3210 C C   . ARG B 1 146 ? 5.12337   -0.38371  -18.43084 1.000 31.94968 ? 498 ARG B C   1 
ATOM   3211 O O   . ARG B 1 146 ? 5.51734   -0.13058  -17.28172 1.000 27.89006 ? 498 ARG B O   1 
ATOM   3212 C CB  . ARG B 1 146 ? 6.62892   -2.17458  -19.29632 1.000 26.64369 ? 498 ARG B CB  1 
ATOM   3213 C CG  . ARG B 1 146 ? 7.33422   -1.22559  -20.25730 1.000 38.64170 ? 498 ARG B CG  1 
ATOM   3214 C CD  . ARG B 1 146 ? 8.83799   -1.51820  -20.25209 1.000 42.77540 ? 498 ARG B CD  1 
ATOM   3215 N NE  . ARG B 1 146 ? 9.26972   -1.85982  -18.89838 1.000 61.81934 ? 498 ARG B NE  1 
ATOM   3216 C CZ  . ARG B 1 146 ? 10.52658  -1.87171  -18.47208 1.000 71.69261 ? 498 ARG B CZ  1 
ATOM   3217 N NH1 . ARG B 1 146 ? 11.53547  -1.55431  -19.27140 1.000 57.93459 ? 498 ARG B NH1 1 
ATOM   3218 N NH2 . ARG B 1 146 ? 10.77647  -2.20345  -17.20702 1.000 75.01097 ? 498 ARG B NH2 1 
ATOM   3219 N N   . ASN B 1 147 ? 4.64290   0.54496   -19.24818 1.000 24.70672 ? 499 ASN B N   1 
ATOM   3220 C CA  . ASN B 1 147 ? 4.52188   1.94461   -18.87263 1.000 28.20553 ? 499 ASN B CA  1 
ATOM   3221 C C   . ASN B 1 147 ? 3.10649   2.31533   -18.45682 1.000 28.97108 ? 499 ASN B C   1 
ATOM   3222 O O   . ASN B 1 147 ? 2.78209   3.50424   -18.36045 1.000 32.79501 ? 499 ASN B O   1 
ATOM   3223 C CB  . ASN B 1 147 ? 5.00008   2.81387   -20.03111 1.000 23.69307 ? 499 ASN B CB  1 
ATOM   3224 C CG  . ASN B 1 147 ? 6.48819   2.67465   -20.25943 1.000 31.63969 ? 499 ASN B CG  1 
ATOM   3225 O OD1 . ASN B 1 147 ? 7.22212   2.30372   -19.33950 1.000 31.42595 ? 499 ASN B OD1 1 
ATOM   3226 N ND2 . ASN B 1 147 ? 6.94760   2.97995   -21.47154 1.000 25.45619 ? 499 ASN B ND2 1 
ATOM   3227 N N   . VAL B 1 148 ? 2.25585   1.32785   -18.21784 1.000 27.44882 ? 500 VAL B N   1 
ATOM   3228 C CA  . VAL B 1 148 ? 0.93248   1.53854   -17.64799 1.000 24.99573 ? 500 VAL B CA  1 
ATOM   3229 C C   . VAL B 1 148 ? 0.98140   1.06734   -16.20022 1.000 29.46351 ? 500 VAL B C   1 
ATOM   3230 O O   . VAL B 1 148 ? 1.44602   -0.04236  -15.92396 1.000 28.55324 ? 500 VAL B O   1 
ATOM   3231 C CB  . VAL B 1 148 ? -0.13611  0.78443   -18.46019 1.000 25.66916 ? 500 VAL B CB  1 
ATOM   3232 C CG1 . VAL B 1 148 ? -1.48001  0.79430   -17.73921 1.000 28.84582 ? 500 VAL B CG1 1 
ATOM   3233 C CG2 . VAL B 1 148 ? -0.26637  1.41506   -19.83884 1.000 27.29953 ? 500 VAL B CG2 1 
ATOM   3234 N N   . LEU B 1 149 ? 0.52948   1.91220   -15.27626 1.000 25.81474 ? 501 LEU B N   1 
ATOM   3235 C CA  . LEU B 1 149 ? 0.57595   1.59430   -13.85716 1.000 30.73349 ? 501 LEU B CA  1 
ATOM   3236 C C   . LEU B 1 149 ? -0.83676  1.46109   -13.31639 1.000 30.77312 ? 501 LEU B C   1 
ATOM   3237 O O   . LEU B 1 149 ? -1.73059  2.22016   -13.70330 1.000 34.86623 ? 501 LEU B O   1 
ATOM   3238 C CB  . LEU B 1 149 ? 1.34573   2.65545   -13.07885 1.000 28.19911 ? 501 LEU B CB  1 
ATOM   3239 C CG  . LEU B 1 149 ? 2.82707   2.44331   -13.37467 1.000 35.32441 ? 501 LEU B CG  1 
ATOM   3240 C CD1 . LEU B 1 149 ? 3.52430   3.73715   -13.28952 1.000 41.92730 ? 501 LEU B CD1 1 
ATOM   3241 C CD2 . LEU B 1 149 ? 3.43750   1.43261   -12.39998 1.000 37.81351 ? 501 LEU B CD2 1 
ATOM   3242 N N   . LEU B 1 150 ? -1.02306  0.48360   -12.42990 1.000 29.31551 ? 502 LEU B N   1 
ATOM   3243 C CA  . LEU B 1 150 ? -2.32608  0.14310   -11.87761 1.000 30.66420 ? 502 LEU B CA  1 
ATOM   3244 C C   . LEU B 1 150 ? -2.44970  0.72791   -10.47772 1.000 28.06352 ? 502 LEU B C   1 
ATOM   3245 O O   . LEU B 1 150 ? -1.62750  0.43722   -9.60474  1.000 31.68007 ? 502 LEU B O   1 
ATOM   3246 C CB  . LEU B 1 150 ? -2.52077  -1.37490  -11.84929 1.000 31.91365 ? 502 LEU B CB  1 
ATOM   3247 C CG  . LEU B 1 150 ? -2.52381  -2.04080  -13.22307 1.000 36.60372 ? 502 LEU B CG  1 
ATOM   3248 C CD1 . LEU B 1 150 ? -2.80330  -3.51463  -13.09146 1.000 34.79150 ? 502 LEU B CD1 1 
ATOM   3249 C CD2 . LEU B 1 150 ? -3.56066  -1.36715  -14.13197 1.000 36.24786 ? 502 LEU B CD2 1 
ATOM   3250 N N   . VAL B 1 151 ? -3.45419  1.57960   -10.28485 1.000 33.46080 ? 503 VAL B N   1 
ATOM   3251 C CA  . VAL B 1 151 ? -3.79034  2.07893   -8.95664  1.000 35.53517 ? 503 VAL B CA  1 
ATOM   3252 C C   . VAL B 1 151 ? -4.59452  1.03753   -8.19475  1.000 35.71192 ? 503 VAL B C   1 
ATOM   3253 O O   . VAL B 1 151 ? -4.30011  0.71987   -7.03825  1.000 34.84501 ? 503 VAL B O   1 
ATOM   3254 C CB  . VAL B 1 151 ? -4.55513  3.40732   -9.08877  1.000 30.87614 ? 503 VAL B CB  1 
ATOM   3255 C CG1 . VAL B 1 151 ? -4.92381  3.97889   -7.72824  1.000 32.05157 ? 503 VAL B CG1 1 
ATOM   3256 C CG2 . VAL B 1 151 ? -3.71964  4.39289   -9.89386  1.000 33.59145 ? 503 VAL B CG2 1 
ATOM   3257 N N   . THR B 1 152 ? -5.62741  0.50240   -8.83795  1.000 32.68307 ? 504 THR B N   1 
ATOM   3258 C CA  . THR B 1 152 ? -6.35313  -0.67848  -8.40038  1.000 40.12955 ? 504 THR B CA  1 
ATOM   3259 C C   . THR B 1 152 ? -6.42460  -1.62436  -9.58993  1.000 39.67660 ? 504 THR B C   1 
ATOM   3260 O O   . THR B 1 152 ? -5.95226  -1.30387  -10.68662 1.000 36.55684 ? 504 THR B O   1 
ATOM   3261 C CB  . THR B 1 152 ? -7.76476  -0.32693  -7.92001  1.000 36.20701 ? 504 THR B CB  1 
ATOM   3262 O OG1 . THR B 1 152 ? -8.54054  0.09248   -9.05186  1.000 36.82686 ? 504 THR B OG1 1 
ATOM   3263 C CG2 . THR B 1 152 ? -7.72344  0.81667   -6.91426  1.000 37.20641 ? 504 THR B CG2 1 
ATOM   3264 N N   . GLN B 1 153 ? -7.04090  -2.78933  -9.39773  1.000 34.53052 ? 505 GLN B N   1 
ATOM   3265 C CA  . GLN B 1 153 ? -7.23847  -3.66297  -10.55435 1.000 32.38538 ? 505 GLN B CA  1 
ATOM   3266 C C   . GLN B 1 153 ? -8.18309  -3.05475  -11.58526 1.000 33.34075 ? 505 GLN B C   1 
ATOM   3267 O O   . GLN B 1 153 ? -8.27766  -3.58113  -12.70084 1.000 35.53263 ? 505 GLN B O   1 
ATOM   3268 C CB  . GLN B 1 153 ? -7.75925  -5.02777  -10.10187 1.000 41.42837 ? 505 GLN B CB  1 
ATOM   3269 C CG  . GLN B 1 153 ? -7.44243  -6.15585  -11.06965 1.000 47.29775 ? 505 GLN B CG  1 
ATOM   3270 C CD  . GLN B 1 153 ? -7.74638  -7.52335  -10.49243 1.000 54.24140 ? 505 GLN B CD  1 
ATOM   3271 O OE1 . GLN B 1 153 ? -6.91876  -8.12061  -9.79377  1.000 51.83377 ? 505 GLN B OE1 1 
ATOM   3272 N NE2 . GLN B 1 153 ? -8.93576  -8.02981  -10.78437 1.000 40.52125 ? 505 GLN B NE2 1 
ATOM   3273 N N   . HIS B 1 154 ? -8.85550  -1.94379  -11.24550 1.000 30.53493 ? 506 HIS B N   1 
ATOM   3274 C CA  . HIS B 1 154 ? -9.83591  -1.29154  -12.10421 1.000 34.57223 ? 506 HIS B CA  1 
ATOM   3275 C C   . HIS B 1 154 ? -9.47142  0.15482   -12.40797 1.000 34.08664 ? 506 HIS B C   1 
ATOM   3276 O O   . HIS B 1 154 ? -10.34072 0.94370   -12.79377 1.000 35.77076 ? 506 HIS B O   1 
ATOM   3277 C CB  . HIS B 1 154 ? -11.21902 -1.36608  -11.45285 1.000 42.35106 ? 506 HIS B CB  1 
ATOM   3278 C CG  . HIS B 1 154 ? -11.70659 -2.76348  -11.29049 1.000 41.12838 ? 506 HIS B CG  1 
ATOM   3279 N ND1 . HIS B 1 154 ? -12.38779 -3.42688  -12.28796 1.000 39.27811 ? 506 HIS B ND1 1 
ATOM   3280 C CD2 . HIS B 1 154 ? -11.56339 -3.64697  -10.27476 1.000 41.47118 ? 506 HIS B CD2 1 
ATOM   3281 C CE1 . HIS B 1 154 ? -12.65796 -4.65575  -11.88584 1.000 46.32374 ? 506 HIS B CE1 1 
ATOM   3282 N NE2 . HIS B 1 154 ? -12.16719 -4.81485  -10.66906 1.000 45.70438 ? 506 HIS B NE2 1 
ATOM   3283 N N   . TYR B 1 155 ? -8.20820  0.53742   -12.22832 1.000 29.34831 ? 507 TYR B N   1 
ATOM   3284 C CA  . TYR B 1 155 ? -7.83137  1.93006   -12.44496 1.000 26.15305 ? 507 TYR B CA  1 
ATOM   3285 C C   . TYR B 1 155 ? -6.39087  1.94485   -12.93663 1.000 30.46762 ? 507 TYR B C   1 
ATOM   3286 O O   . TYR B 1 155 ? -5.48159  1.61887   -12.16917 1.000 32.93824 ? 507 TYR B O   1 
ATOM   3287 C CB  . TYR B 1 155 ? -8.00622  2.73527   -11.15446 1.000 32.80328 ? 507 TYR B CB  1 
ATOM   3288 C CG  . TYR B 1 155 ? -7.78188  4.22504   -11.24535 1.000 35.23592 ? 507 TYR B CG  1 
ATOM   3289 C CD1 . TYR B 1 155 ? -7.56989  4.86238   -12.46473 1.000 31.08243 ? 507 TYR B CD1 1 
ATOM   3290 C CD2 . TYR B 1 155 ? -7.77360  5.00317   -10.08889 1.000 30.43578 ? 507 TYR B CD2 1 
ATOM   3291 C CE1 . TYR B 1 155 ? -7.36625  6.23756   -12.52085 1.000 32.23456 ? 507 TYR B CE1 1 
ATOM   3292 C CE2 . TYR B 1 155 ? -7.56741  6.36343   -10.13828 1.000 37.56946 ? 507 TYR B CE2 1 
ATOM   3293 C CZ  . TYR B 1 155 ? -7.36193  6.97545   -11.34985 1.000 36.58891 ? 507 TYR B CZ  1 
ATOM   3294 O OH  . TYR B 1 155 ? -7.15681  8.33608   -11.37572 1.000 42.07330 ? 507 TYR B OH  1 
ATOM   3295 N N   . ALA B 1 156 ? -6.19222  2.31145   -14.20532 1.000 30.73096 ? 508 ALA B N   1 
ATOM   3296 C CA  . ALA B 1 156 ? -4.87400  2.35844   -14.81875 1.000 33.14021 ? 508 ALA B CA  1 
ATOM   3297 C C   . ALA B 1 156 ? -4.46316  3.80032   -15.09993 1.000 25.96545 ? 508 ALA B C   1 
ATOM   3298 O O   . ALA B 1 156 ? -5.30428  4.67156   -15.29422 1.000 27.42302 ? 508 ALA B O   1 
ATOM   3299 C CB  . ALA B 1 156 ? -4.84145  1.54207   -16.11717 1.000 28.30525 ? 508 ALA B CB  1 
ATOM   3300 N N   . LYS B 1 157 ? -3.14887  4.04060   -15.11029 1.000 26.75826 ? 509 LYS B N   1 
ATOM   3301 C CA  . LYS B 1 157 ? -2.56943  5.35136   -15.37986 1.000 25.69572 ? 509 LYS B CA  1 
ATOM   3302 C C   . LYS B 1 157 ? -1.32513  5.17366   -16.25121 1.000 25.31077 ? 509 LYS B C   1 
ATOM   3303 O O   . LYS B 1 157 ? -0.58014  4.20971   -16.09483 1.000 29.38657 ? 509 LYS B O   1 
ATOM   3304 C CB  . LYS B 1 157 ? -2.15197  6.08943   -14.08210 1.000 27.48713 ? 509 LYS B CB  1 
ATOM   3305 C CG  . LYS B 1 157 ? -3.27669  6.69756   -13.23656 1.000 32.26312 ? 509 LYS B CG  1 
ATOM   3306 C CD  . LYS B 1 157 ? -2.70222  7.10689   -11.86053 1.000 37.56166 ? 509 LYS B CD  1 
ATOM   3307 C CE  . LYS B 1 157 ? -3.70717  7.79518   -10.96096 1.000 34.06582 ? 509 LYS B CE  1 
ATOM   3308 N NZ  . LYS B 1 157 ? -3.65368  9.27130   -11.12141 1.000 39.02624 ? 509 LYS B NZ  1 
ATOM   3309 N N   . ILE B 1 158 ? -1.08621  6.12863   -17.13811 1.000 30.49045 ? 510 ILE B N   1 
ATOM   3310 C CA  . ILE B 1 158 ? 0.10533   6.14386   -17.98343 1.000 26.60766 ? 510 ILE B CA  1 
ATOM   3311 C C   . ILE B 1 158 ? 1.24348   6.81518   -17.23247 1.000 24.51578 ? 510 ILE B C   1 
ATOM   3312 O O   . ILE B 1 158 ? 1.04365   7.83183   -16.55402 1.000 25.85206 ? 510 ILE B O   1 
ATOM   3313 C CB  . ILE B 1 158 ? -0.18616  6.87807   -19.30485 1.000 26.73964 ? 510 ILE B CB  1 
ATOM   3314 C CG1 . ILE B 1 158 ? -1.36007  6.20729   -20.01822 1.000 26.25399 ? 510 ILE B CG1 1 
ATOM   3315 C CG2 . ILE B 1 158 ? 1.08165   6.93092   -20.19328 1.000 26.80191 ? 510 ILE B CG2 1 
ATOM   3316 C CD1 . ILE B 1 158 ? -2.07774  7.10982   -20.99567 1.000 27.20718 ? 510 ILE B CD1 1 
ATOM   3317 N N   . SER B 1 159 ? 2.45451   6.28023   -17.37709 1.000 28.92178 ? 511 SER B N   1 
ATOM   3318 C CA  . SER B 1 159 ? 3.64053   6.94170   -16.82607 1.000 25.50775 ? 511 SER B CA  1 
ATOM   3319 C C   . SER B 1 159 ? 4.74506   6.88272   -17.88353 1.000 27.78288 ? 511 SER B C   1 
ATOM   3320 O O   . SER B 1 159 ? 4.48181   6.60823   -19.05726 1.000 26.55891 ? 511 SER B O   1 
ATOM   3321 C CB  . SER B 1 159 ? 4.07215   6.30759   -15.49283 1.000 27.43275 ? 511 SER B CB  1 
ATOM   3322 O OG  . SER B 1 159 ? 5.02238   7.11658   -14.78500 1.000 30.67806 ? 511 SER B OG  1 
ATOM   3323 N N   . ASP B 1 160 ? 5.98353   7.17914   -17.46078 1.000 25.18740 ? 512 ASP B N   1 
ATOM   3324 C CA  . ASP B 1 160 ? 7.19826   7.05782   -18.27790 1.000 25.64779 ? 512 ASP B CA  1 
ATOM   3325 C C   . ASP B 1 160 ? 7.22950   8.00106   -19.46624 1.000 28.46117 ? 512 ASP B C   1 
ATOM   3326 O O   . ASP B 1 160 ? 7.19008   7.56282   -20.62348 1.000 29.43176 ? 512 ASP B O   1 
ATOM   3327 C CB  . ASP B 1 160 ? 7.38589   5.62580   -18.77734 1.000 30.11198 ? 512 ASP B CB  1 
ATOM   3328 C CG  . ASP B 1 160 ? 7.87807   4.71099   -17.69189 1.000 47.27379 ? 512 ASP B CG  1 
ATOM   3329 O OD1 . ASP B 1 160 ? 7.03234   4.21219   -16.92912 1.000 43.46924 ? 512 ASP B OD1 1 
ATOM   3330 O OD2 . ASP B 1 160 ? 9.10848   4.51769   -17.57708 1.000 44.22602 ? 512 ASP B OD2 1 
ATOM   3331 N N   . PHE B 1 161 ? 7.34615   9.29533   -19.18734 1.000 24.26918 ? 513 PHE B N   1 
ATOM   3332 C CA  . PHE B 1 161 ? 7.36657   10.32417  -20.21592 1.000 30.52786 ? 513 PHE B CA  1 
ATOM   3333 C C   . PHE B 1 161 ? 8.78121   10.71895  -20.63229 1.000 32.15659 ? 513 PHE B C   1 
ATOM   3334 O O   . PHE B 1 161 ? 8.98084   11.82829  -21.14080 1.000 30.39701 ? 513 PHE B O   1 
ATOM   3335 C CB  . PHE B 1 161 ? 6.57093   11.53609  -19.72378 1.000 23.75184 ? 513 PHE B CB  1 
ATOM   3336 C CG  . PHE B 1 161 ? 5.10776   11.23079  -19.56867 1.000 28.41289 ? 513 PHE B CG  1 
ATOM   3337 C CD1 . PHE B 1 161 ? 4.62107   10.71668  -18.38104 1.000 29.42628 ? 513 PHE B CD1 1 
ATOM   3338 C CD2 . PHE B 1 161 ? 4.23789   11.40526  -20.63360 1.000 26.34083 ? 513 PHE B CD2 1 
ATOM   3339 C CE1 . PHE B 1 161 ? 3.27800   10.40402  -18.24742 1.000 25.55947 ? 513 PHE B CE1 1 
ATOM   3340 C CE2 . PHE B 1 161 ? 2.90353   11.10157  -20.49971 1.000 25.13857 ? 513 PHE B CE2 1 
ATOM   3341 C CZ  . PHE B 1 161 ? 2.43502   10.58876  -19.29831 1.000 25.09780 ? 513 PHE B CZ  1 
ATOM   3342 N N   . GLY B 1 162 ? 9.75915   9.82548   -20.44220 1.000 28.04976 ? 514 GLY B N   1 
ATOM   3343 C CA  . GLY B 1 162 ? 11.13930  10.14916  -20.77991 1.000 29.30503 ? 514 GLY B CA  1 
ATOM   3344 C C   . GLY B 1 162 ? 11.37439  10.43454  -22.25566 1.000 34.92641 ? 514 GLY B C   1 
ATOM   3345 O O   . GLY B 1 162 ? 12.31212  11.16023  -22.60703 1.000 33.91439 ? 514 GLY B O   1 
ATOM   3346 N N   . LEU B 1 163 ? 10.55903  9.85632   -23.14020 1.000 29.72039 ? 515 LEU B N   1 
ATOM   3347 C CA  . LEU B 1 163 ? 10.68319  10.09579  -24.57708 1.000 33.45841 ? 515 LEU B CA  1 
ATOM   3348 C C   . LEU B 1 163 ? 9.65660   11.09108  -25.12181 1.000 28.00968 ? 515 LEU B C   1 
ATOM   3349 O O   . LEU B 1 163 ? 9.69327   11.40399  -26.31874 1.000 29.53011 ? 515 LEU B O   1 
ATOM   3350 C CB  . LEU B 1 163 ? 10.56835  8.77094   -25.35404 1.000 31.19451 ? 515 LEU B CB  1 
ATOM   3351 C CG  . LEU B 1 163 ? 11.67111  7.72813   -25.14428 1.000 31.30631 ? 515 LEU B CG  1 
ATOM   3352 C CD1 . LEU B 1 163 ? 11.46727  6.54979   -26.08720 1.000 35.07937 ? 515 LEU B CD1 1 
ATOM   3353 C CD2 . LEU B 1 163 ? 13.03675  8.34767   -25.34601 1.000 36.24401 ? 515 LEU B CD2 1 
ATOM   3354 N N   . SER B 1 164 ? 8.75304   11.59918  -24.28516 1.000 28.55327 ? 516 SER B N   1 
ATOM   3355 C CA  . SER B 1 164 ? 7.61652   12.36026  -24.78401 1.000 31.12756 ? 516 SER B CA  1 
ATOM   3356 C C   . SER B 1 164 ? 8.06429   13.73018  -25.26756 1.000 31.58118 ? 516 SER B C   1 
ATOM   3357 O O   . SER B 1 164 ? 9.08318   14.26019  -24.83265 1.000 31.70102 ? 516 SER B O   1 
ATOM   3358 C CB  . SER B 1 164 ? 6.55082   12.52423  -23.69868 1.000 28.32886 ? 516 SER B CB  1 
ATOM   3359 O OG  . SER B 1 164 ? 6.19837   11.25865  -23.18512 1.000 38.35902 ? 516 SER B OG  1 
ATOM   3360 N N   . LYS B 1 165 ? 7.27770   14.30507  -26.16985 1.000 28.44004 ? 517 LYS B N   1 
ATOM   3361 C CA  . LYS B 1 165 ? 7.60965   15.56584  -26.81585 1.000 32.18911 ? 517 LYS B CA  1 
ATOM   3362 C C   . LYS B 1 165 ? 6.34931   16.40748  -26.94282 1.000 28.91076 ? 517 LYS B C   1 
ATOM   3363 O O   . LYS B 1 165 ? 5.29173   15.89190  -27.30014 1.000 27.50148 ? 517 LYS B O   1 
ATOM   3364 C CB  . LYS B 1 165 ? 8.22054   15.33617  -28.21223 1.000 33.04500 ? 517 LYS B CB  1 
ATOM   3365 C CG  . LYS B 1 165 ? 9.44249   14.43174  -28.25966 1.000 30.82519 ? 517 LYS B CG  1 
ATOM   3366 C CD  . LYS B 1 165 ? 10.60263  15.04380  -27.47078 1.000 35.53671 ? 517 LYS B CD  1 
ATOM   3367 C CE  . LYS B 1 165 ? 11.91592  14.35349  -27.77268 1.000 46.68751 ? 517 LYS B CE  1 
ATOM   3368 N NZ  . LYS B 1 165 ? 13.08224  15.10748  -27.20848 1.000 32.37087 ? 517 LYS B NZ  1 
ATOM   3369 N N   . ALA B 1 166 ? 6.45874   17.70303  -26.65439 1.000 33.77967 ? 518 ALA B N   1 
ATOM   3370 C CA  . ALA B 1 166 ? 5.38101   18.63465  -26.97230 1.000 34.70450 ? 518 ALA B CA  1 
ATOM   3371 C C   . ALA B 1 166 ? 5.46920   18.98981  -28.44924 1.000 28.41315 ? 518 ALA B C   1 
ATOM   3372 O O   . ALA B 1 166 ? 6.54156   19.35200  -28.93886 1.000 31.88305 ? 518 ALA B O   1 
ATOM   3373 C CB  . ALA B 1 166 ? 5.47479   19.90010  -26.11258 1.000 35.47515 ? 518 ALA B CB  1 
ATOM   3374 N N   . LEU B 1 167 ? 4.36402   18.83643  -29.17000 1.000 28.05149 ? 519 LEU B N   1 
ATOM   3375 C CA  . LEU B 1 167 ? 4.40410   19.02950  -30.60751 1.000 30.76127 ? 519 LEU B CA  1 
ATOM   3376 C C   . LEU B 1 167 ? 4.51168   20.51307  -30.94797 1.000 34.52565 ? 519 LEU B C   1 
ATOM   3377 O O   . LEU B 1 167 ? 3.98799   21.37390  -30.23189 1.000 30.28287 ? 519 LEU B O   1 
ATOM   3378 C CB  . LEU B 1 167 ? 3.15706   18.43855  -31.26624 1.000 28.44168 ? 519 LEU B CB  1 
ATOM   3379 C CG  . LEU B 1 167 ? 3.10415   16.91159  -31.38166 1.000 33.06110 ? 519 LEU B CG  1 
ATOM   3380 C CD1 . LEU B 1 167 ? 1.74708   16.47157  -31.92164 1.000 36.44931 ? 519 LEU B CD1 1 
ATOM   3381 C CD2 . LEU B 1 167 ? 4.23341   16.41121  -32.25729 1.000 32.10530 ? 519 LEU B CD2 1 
ATOM   3382 N N   . ARG B 1 168 ? 5.21513   20.79840  -32.04604 1.000 28.02640 ? 520 ARG B N   1 
ATOM   3383 C CA  . ARG B 1 168 ? 5.25889   22.14328  -32.60605 1.000 32.77694 ? 520 ARG B CA  1 
ATOM   3384 C C   . ARG B 1 168 ? 3.86585   22.61549  -33.00349 1.000 36.50570 ? 520 ARG B C   1 
ATOM   3385 O O   . ARG B 1 168 ? 3.00661   21.82361  -33.39666 1.000 34.44489 ? 520 ARG B O   1 
ATOM   3386 C CB  . ARG B 1 168 ? 6.14739   22.18022  -33.84570 1.000 36.81176 ? 520 ARG B CB  1 
ATOM   3387 C CG  . ARG B 1 168 ? 7.62648   22.09112  -33.60994 1.000 47.45090 ? 520 ARG B CG  1 
ATOM   3388 C CD  . ARG B 1 168 ? 8.31011   21.77325  -34.94016 1.000 50.34335 ? 520 ARG B CD  1 
ATOM   3389 N NE  . ARG B 1 168 ? 7.98324   22.75776  -35.96940 1.000 53.22434 ? 520 ARG B NE  1 
ATOM   3390 C CZ  . ARG B 1 168 ? 8.73707   23.81473  -36.24202 1.000 49.19781 ? 520 ARG B CZ  1 
ATOM   3391 N NH1 . ARG B 1 168 ? 9.85550   24.05000  -35.58066 1.000 52.49367 ? 520 ARG B NH1 1 
ATOM   3392 N NH2 . ARG B 1 168 ? 8.36514   24.64903  -37.20807 1.000 52.25728 ? 520 ARG B NH2 1 
ATOM   3393 N N   . ALA B 1 169 ? 3.66522   23.93857  -32.96148 1.000 36.67674 ? 521 ALA B N   1 
ATOM   3394 C CA  . ALA B 1 169 ? 2.35834   24.48674  -33.30104 1.000 29.89892 ? 521 ALA B CA  1 
ATOM   3395 C C   . ALA B 1 169 ? 1.98452   24.22147  -34.75538 1.000 29.76092 ? 521 ALA B C   1 
ATOM   3396 O O   . ALA B 1 169 ? 0.79683   24.10169  -35.07478 1.000 33.19380 ? 521 ALA B O   1 
ATOM   3397 C CB  . ALA B 1 169 ? 2.32150   25.99876  -33.01750 1.000 23.51206 ? 521 ALA B CB  1 
ATOM   3398 N N   . ASP B 1 170 ? 2.96536   24.10211  -35.64273 1.000 28.81209 ? 522 ASP B N   1 
ATOM   3399 C CA  . ASP B 1 170 ? 2.70349   24.02801  -37.07537 1.000 36.72276 ? 522 ASP B CA  1 
ATOM   3400 C C   . ASP B 1 170 ? 2.77558   22.61383  -37.65086 1.000 44.99021 ? 522 ASP B C   1 
ATOM   3401 O O   . ASP B 1 170 ? 2.64521   22.45613  -38.87020 1.000 35.63537 ? 522 ASP B O   1 
ATOM   3402 C CB  . ASP B 1 170 ? 3.68602   24.91397  -37.83737 1.000 35.09011 ? 522 ASP B CB  1 
ATOM   3403 C CG  . ASP B 1 170 ? 5.12801   24.62570  -37.47123 1.000 36.31682 ? 522 ASP B CG  1 
ATOM   3404 O OD1 . ASP B 1 170 ? 5.35886   23.91678  -36.47394 1.000 38.88542 ? 522 ASP B OD1 1 
ATOM   3405 O OD2 . ASP B 1 170 ? 6.03827   25.10794  -38.17368 1.000 44.16699 ? 522 ASP B OD2 1 
ATOM   3406 N N   . GLU B 1 171 ? 3.00476   21.58739  -36.82823 1.000 40.43429 ? 523 GLU B N   1 
ATOM   3407 C CA  . GLU B 1 171 ? 3.13147   20.22253  -37.33485 1.000 44.53813 ? 523 GLU B CA  1 
ATOM   3408 C C   . GLU B 1 171 ? 2.46233   19.25785  -36.36831 1.000 42.53501 ? 523 GLU B C   1 
ATOM   3409 O O   . GLU B 1 171 ? 2.34302   19.53333  -35.17301 1.000 38.83508 ? 523 GLU B O   1 
ATOM   3410 C CB  . GLU B 1 171 ? 4.60141   19.81775  -37.53860 1.000 40.15099 ? 523 GLU B CB  1 
ATOM   3411 C CG  . GLU B 1 171 ? 5.43887   20.85468  -38.28443 1.000 53.90398 ? 523 GLU B CG  1 
ATOM   3412 C CD  . GLU B 1 171 ? 6.64877   20.27067  -39.00138 1.000 74.38843 ? 523 GLU B CD  1 
ATOM   3413 O OE1 . GLU B 1 171 ? 7.16191   19.20881  -38.57364 1.000 76.83717 ? 523 GLU B OE1 1 
ATOM   3414 O OE2 . GLU B 1 171 ? 7.08386   20.88174  -40.00748 1.000 82.41252 ? 523 GLU B OE2 1 
ATOM   3415 N N   . ASN B 1 172 ? 2.02382   18.11354  -36.88670 1.000 38.09921 ? 524 ASN B N   1 
ATOM   3416 C CA  . ASN B 1 172 ? 1.39962   17.12454  -36.02157 1.000 42.21752 ? 524 ASN B CA  1 
ATOM   3417 C C   . ASN B 1 172 ? 2.32345   15.94210  -35.73100 1.000 37.19369 ? 524 ASN B C   1 
ATOM   3418 O O   . ASN B 1 172 ? 1.85395   14.89150  -35.27858 1.000 32.17214 ? 524 ASN B O   1 
ATOM   3419 C CB  . ASN B 1 172 ? 0.05463   16.66866  -36.60861 1.000 40.67012 ? 524 ASN B CB  1 
ATOM   3420 C CG  . ASN B 1 172 ? 0.19975   15.86856  -37.88419 1.000 45.62422 ? 524 ASN B CG  1 
ATOM   3421 O OD1 . ASN B 1 172 ? 1.23040   15.92181  -38.55890 1.000 53.76945 ? 524 ASN B OD1 1 
ATOM   3422 N ND2 . ASN B 1 172 ? -0.85008  15.12716  -38.23266 1.000 52.55926 ? 524 ASN B ND2 1 
ATOM   3423 N N   . TYR B 1 173 ? 3.63422   16.11400  -35.92107 1.000 31.88510 ? 525 TYR B N   1 
ATOM   3424 C CA  . TYR B 1 173 ? 4.58014   15.04663  -35.65135 1.000 34.36062 ? 525 TYR B CA  1 
ATOM   3425 C C   . TYR B 1 173 ? 5.90344   15.64754  -35.18177 1.000 43.84648 ? 525 TYR B C   1 
ATOM   3426 O O   . TYR B 1 173 ? 6.24410   16.78886  -35.51459 1.000 37.72361 ? 525 TYR B O   1 
ATOM   3427 C CB  . TYR B 1 173 ? 4.80721   14.17260  -36.88969 1.000 39.05373 ? 525 TYR B CB  1 
ATOM   3428 C CG  . TYR B 1 173 ? 5.50469   14.91927  -37.99429 1.000 40.89922 ? 525 TYR B CG  1 
ATOM   3429 C CD1 . TYR B 1 173 ? 4.77929   15.67900  -38.91374 1.000 40.71578 ? 525 TYR B CD1 1 
ATOM   3430 C CD2 . TYR B 1 173 ? 6.89129   14.88863  -38.10751 1.000 38.38499 ? 525 TYR B CD2 1 
ATOM   3431 C CE1 . TYR B 1 173 ? 5.42647   16.38414  -39.92228 1.000 53.17764 ? 525 TYR B CE1 1 
ATOM   3432 C CE2 . TYR B 1 173 ? 7.53840   15.57935  -39.10215 1.000 48.46964 ? 525 TYR B CE2 1 
ATOM   3433 C CZ  . TYR B 1 173 ? 6.81006   16.32440  -40.00819 1.000 50.34419 ? 525 TYR B CZ  1 
ATOM   3434 O OH  . TYR B 1 173 ? 7.47862   17.00614  -40.99654 1.000 55.20840 ? 525 TYR B OH  1 
ATOM   3435 N N   . TYR B 1 174 ? 6.62779   14.86539  -34.38977 1.000 29.83662 ? 526 TYR B N   1 
ATOM   3436 C CA  . TYR B 1 174 ? 8.00871   15.13121  -34.01136 1.000 32.37356 ? 526 TYR B CA  1 
ATOM   3437 C C   . TYR B 1 174 ? 8.93547   14.30038  -34.88951 1.000 39.29668 ? 526 TYR B C   1 
ATOM   3438 O O   . TYR B 1 174 ? 8.69826   13.11169  -35.11220 1.000 33.48716 ? 526 TYR B O   1 
ATOM   3439 C CB  . TYR B 1 174 ? 8.24127   14.79607  -32.53234 1.000 32.36727 ? 526 TYR B CB  1 
ATOM   3440 C CG  . TYR B 1 174 ? 9.69127   14.86499  -32.07456 1.000 41.73506 ? 526 TYR B CG  1 
ATOM   3441 C CD1 . TYR B 1 174 ? 10.29363  16.08571  -31.80521 1.000 40.28610 ? 526 TYR B CD1 1 
ATOM   3442 C CD2 . TYR B 1 174 ? 10.44996  13.70825  -31.90268 1.000 38.03962 ? 526 TYR B CD2 1 
ATOM   3443 C CE1 . TYR B 1 174 ? 11.59962  16.16276  -31.40012 1.000 38.65099 ? 526 TYR B CE1 1 
ATOM   3444 C CE2 . TYR B 1 174 ? 11.77546  13.77839  -31.48523 1.000 37.82512 ? 526 TYR B CE2 1 
ATOM   3445 C CZ  . TYR B 1 174 ? 12.33845  15.01223  -31.23296 1.000 43.67756 ? 526 TYR B CZ  1 
ATOM   3446 O OH  . TYR B 1 174 ? 13.64828  15.11141  -30.81901 1.000 49.60800 ? 526 TYR B OH  1 
ATOM   3447 N N   . LYS B 1 175 ? 9.99068   14.92644  -35.39201 1.000 38.56744 ? 527 LYS B N   1 
ATOM   3448 C CA  . LYS B 1 175 ? 10.98354  14.23921  -36.20190 1.000 35.86073 ? 527 LYS B CA  1 
ATOM   3449 C C   . LYS B 1 175 ? 12.25947  14.12078  -35.38047 1.000 42.49848 ? 527 LYS B C   1 
ATOM   3450 O O   . LYS B 1 175 ? 12.84951  15.13545  -34.99974 1.000 40.61467 ? 527 LYS B O   1 
ATOM   3451 C CB  . LYS B 1 175 ? 11.21541  14.98866  -37.51384 1.000 50.92462 ? 527 LYS B CB  1 
ATOM   3452 C CG  . LYS B 1 175 ? 11.27476  16.50761  -37.35050 1.000 64.34996 ? 527 LYS B CG  1 
ATOM   3453 C CD  . LYS B 1 175 ? 10.80846  17.24058  -38.60612 1.000 70.67149 ? 527 LYS B CD  1 
ATOM   3454 C CE  . LYS B 1 175 ? 11.26888  18.69580  -38.61409 1.000 68.73267 ? 527 LYS B CE  1 
ATOM   3455 N NZ  . LYS B 1 175 ? 10.92431  19.42426  -37.35495 1.000 64.91828 ? 527 LYS B NZ  1 
ATOM   3456 N N   . ALA B 1 176 ? 12.66850  12.88853  -35.08874 1.000 42.36656 ? 528 ALA B N   1 
ATOM   3457 C CA  . ALA B 1 176 ? 13.78546  12.63963  -34.17403 1.000 39.94113 ? 528 ALA B CA  1 
ATOM   3458 C C   . ALA B 1 176 ? 15.12694  13.04214  -34.77424 1.000 41.28179 ? 528 ALA B C   1 
ATOM   3459 O O   . ALA B 1 176 ? 15.48754  12.57690  -35.85696 1.000 49.65740 ? 528 ALA B O   1 
ATOM   3460 C CB  . ALA B 1 176 ? 13.81853  11.17175  -33.76394 1.000 36.10112 ? 528 ALA B CB  1 
ATOM   3461 N N   . PRO B 1 183 ? 12.61739  0.99412   -28.75893 1.000 42.76131 ? 535 PRO B N   1 
ATOM   3462 C CA  . PRO B 1 183 ? 11.49598  0.05376   -28.60674 1.000 44.11660 ? 535 PRO B CA  1 
ATOM   3463 C C   . PRO B 1 183 ? 10.79600  -0.26605  -29.92915 1.000 39.62488 ? 535 PRO B C   1 
ATOM   3464 O O   . PRO B 1 183 ? 9.57262   -0.09770  -30.03364 1.000 31.28722 ? 535 PRO B O   1 
ATOM   3465 C CB  . PRO B 1 183 ? 10.55744  0.79559   -27.65340 1.000 48.41816 ? 535 PRO B CB  1 
ATOM   3466 C CG  . PRO B 1 183 ? 10.80352  2.25377   -27.96552 1.000 36.16626 ? 535 PRO B CG  1 
ATOM   3467 C CD  . PRO B 1 183 ? 12.27912  2.34845   -28.27911 1.000 47.63932 ? 535 PRO B CD  1 
ATOM   3468 N N   . VAL B 1 184 ? 11.58473  -0.75152  -30.89481 1.000 33.52467 ? 536 VAL B N   1 
ATOM   3469 C CA  . VAL B 1 184 ? 11.15377  -0.96373  -32.27865 1.000 41.39134 ? 536 VAL B CA  1 
ATOM   3470 C C   . VAL B 1 184 ? 9.84954   -1.74346  -32.36157 1.000 38.00296 ? 536 VAL B C   1 
ATOM   3471 O O   . VAL B 1 184 ? 9.01336   -1.48023  -33.23468 1.000 31.30653 ? 536 VAL B O   1 
ATOM   3472 C CB  . VAL B 1 184 ? 12.28476  -1.66826  -33.06215 1.000 42.87765 ? 536 VAL B CB  1 
ATOM   3473 C CG1 . VAL B 1 184 ? 11.74434  -2.47251  -34.22800 1.000 44.06858 ? 536 VAL B CG1 1 
ATOM   3474 C CG2 . VAL B 1 184 ? 13.28491  -0.64198  -33.56543 1.000 58.96988 ? 536 VAL B CG2 1 
ATOM   3475 N N   . LYS B 1 185 ? 9.64275   -2.69934  -31.45158 1.000 29.46239 ? 537 LYS B N   1 
ATOM   3476 C CA  . LYS B 1 185 ? 8.49266   -3.58129  -31.56291 1.000 33.13225 ? 537 LYS B CA  1 
ATOM   3477 C C   . LYS B 1 185 ? 7.18814   -2.86664  -31.27302 1.000 26.38482 ? 537 LYS B C   1 
ATOM   3478 O O   . LYS B 1 185 ? 6.12638   -3.44025  -31.51924 1.000 29.57115 ? 537 LYS B O   1 
ATOM   3479 C CB  . LYS B 1 185 ? 8.67094   -4.78412  -30.63147 1.000 27.27718 ? 537 LYS B CB  1 
ATOM   3480 C CG  . LYS B 1 185 ? 9.56425   -5.86146  -31.25925 1.000 29.77778 ? 537 LYS B CG  1 
ATOM   3481 C CD  . LYS B 1 185 ? 10.20599  -6.70213  -30.20646 1.000 30.11480 ? 537 LYS B CD  1 
ATOM   3482 C CE  . LYS B 1 185 ? 11.05810  -7.78374  -30.83826 1.000 29.81720 ? 537 LYS B CE  1 
ATOM   3483 N NZ  . LYS B 1 185 ? 11.29574  -8.77721  -29.78724 1.000 37.02994 ? 537 LYS B NZ  1 
ATOM   3484 N N   . TRP B 1 186 ? 7.25075   -1.63920  -30.76761 1.000 27.45339 ? 538 TRP B N   1 
ATOM   3485 C CA  . TRP B 1 186 ? 6.07672   -0.82300  -30.51312 1.000 30.00287 ? 538 TRP B CA  1 
ATOM   3486 C C   . TRP B 1 186 ? 5.92811   0.30337   -31.51504 1.000 30.55175 ? 538 TRP B C   1 
ATOM   3487 O O   . TRP B 1 186 ? 4.98160   1.08447   -31.40811 1.000 31.37769 ? 538 TRP B O   1 
ATOM   3488 C CB  . TRP B 1 186 ? 6.14168   -0.23815  -29.10244 1.000 27.24545 ? 538 TRP B CB  1 
ATOM   3489 C CG  . TRP B 1 186 ? 5.83629   -1.25621  -28.03900 1.000 34.07046 ? 538 TRP B CG  1 
ATOM   3490 C CD1 . TRP B 1 186 ? 4.62630   -1.47599  -27.43994 1.000 30.45639 ? 538 TRP B CD1 1 
ATOM   3491 C CD2 . TRP B 1 186 ? 6.75181   -2.18994  -27.45251 1.000 25.56724 ? 538 TRP B CD2 1 
ATOM   3492 N NE1 . TRP B 1 186 ? 4.73402   -2.48959  -26.52104 1.000 24.65187 ? 538 TRP B NE1 1 
ATOM   3493 C CE2 . TRP B 1 186 ? 6.02789   -2.94478  -26.50854 1.000 29.36273 ? 538 TRP B CE2 1 
ATOM   3494 C CE3 . TRP B 1 186 ? 8.12165   -2.45748  -27.63146 1.000 30.85028 ? 538 TRP B CE3 1 
ATOM   3495 C CZ2 . TRP B 1 186 ? 6.61699   -3.96186  -25.74705 1.000 30.54368 ? 538 TRP B CZ2 1 
ATOM   3496 C CZ3 . TRP B 1 186 ? 8.70494   -3.46746  -26.87582 1.000 36.65181 ? 538 TRP B CZ3 1 
ATOM   3497 C CH2 . TRP B 1 186 ? 7.95217   -4.20340  -25.94004 1.000 33.14632 ? 538 TRP B CH2 1 
ATOM   3498 N N   . TYR B 1 187 ? 6.83683   0.41115   -32.47363 1.000 29.19771 ? 539 TYR B N   1 
ATOM   3499 C CA  . TYR B 1 187 ? 6.93421   1.58887   -33.31775 1.000 29.34236 ? 539 TYR B CA  1 
ATOM   3500 C C   . TYR B 1 187 ? 6.24841   1.36050   -34.65789 1.000 32.91249 ? 539 TYR B C   1 
ATOM   3501 O O   . TYR B 1 187 ? 6.35381   0.28589   -35.25715 1.000 32.23807 ? 539 TYR B O   1 
ATOM   3502 C CB  . TYR B 1 187 ? 8.40429   1.98603   -33.50905 1.000 30.38036 ? 539 TYR B CB  1 
ATOM   3503 C CG  . TYR B 1 187 ? 8.91704   2.87616   -32.38241 1.000 36.24482 ? 539 TYR B CG  1 
ATOM   3504 C CD1 . TYR B 1 187 ? 8.10462   3.17669   -31.28411 1.000 39.41967 ? 539 TYR B CD1 1 
ATOM   3505 C CD2 . TYR B 1 187 ? 10.19799  3.42679   -32.41854 1.000 44.03225 ? 539 TYR B CD2 1 
ATOM   3506 C CE1 . TYR B 1 187 ? 8.55646   4.00796   -30.25027 1.000 36.86222 ? 539 TYR B CE1 1 
ATOM   3507 C CE2 . TYR B 1 187 ? 10.66384  4.25110   -31.38999 1.000 35.63480 ? 539 TYR B CE2 1 
ATOM   3508 C CZ  . TYR B 1 187 ? 9.84027   4.53748   -30.31512 1.000 39.31944 ? 539 TYR B CZ  1 
ATOM   3509 O OH  . TYR B 1 187 ? 10.29854  5.35323   -29.29380 1.000 37.74615 ? 539 TYR B OH  1 
ATOM   3510 N N   . ALA B 1 188 ? 5.52834   2.38183   -35.10691 1.000 29.39610 ? 540 ALA B N   1 
ATOM   3511 C CA  . ALA B 1 188 ? 4.82570   2.34830   -36.37557 1.000 30.41943 ? 540 ALA B CA  1 
ATOM   3512 C C   . ALA B 1 188 ? 5.81279   2.43860   -37.53664 1.000 32.89514 ? 540 ALA B C   1 
ATOM   3513 O O   . ALA B 1 188 ? 6.96619   2.84073   -37.35360 1.000 27.53243 ? 540 ALA B O   1 
ATOM   3514 C CB  . ALA B 1 188 ? 3.83206   3.50743   -36.44888 1.000 27.93842 ? 540 ALA B CB  1 
ATOM   3515 N N   . PRO B 1 189 ? 5.36914   2.07562   -38.75070 1.000 33.00685 ? 541 PRO B N   1 
ATOM   3516 C CA  . PRO B 1 189 ? 6.28645   2.10130   -39.90960 1.000 32.25772 ? 541 PRO B CA  1 
ATOM   3517 C C   . PRO B 1 189 ? 6.92611   3.45071   -40.16245 1.000 35.49075 ? 541 PRO B C   1 
ATOM   3518 O O   . PRO B 1 189 ? 8.12662   3.52155   -40.47498 1.000 37.61478 ? 541 PRO B O   1 
ATOM   3519 C CB  . PRO B 1 189 ? 5.37607   1.69787   -41.07675 1.000 37.41835 ? 541 PRO B CB  1 
ATOM   3520 C CG  . PRO B 1 189 ? 4.30832   0.86456   -40.43969 1.000 32.63275 ? 541 PRO B CG  1 
ATOM   3521 C CD  . PRO B 1 189 ? 4.06942   1.46571   -39.08623 1.000 26.02452 ? 541 PRO B CD  1 
ATOM   3522 N N   . GLU B 1 190 ? 6.15413   4.52882   -40.04849 1.000 31.33178 ? 542 GLU B N   1 
ATOM   3523 C CA  . GLU B 1 190 ? 6.71254   5.85100   -40.28726 1.000 36.92149 ? 542 GLU B CA  1 
ATOM   3524 C C   . GLU B 1 190 ? 7.73508   6.25765   -39.22595 1.000 37.89619 ? 542 GLU B C   1 
ATOM   3525 O O   . GLU B 1 190 ? 8.58065   7.11440   -39.50464 1.000 32.62395 ? 542 GLU B O   1 
ATOM   3526 C CB  . GLU B 1 190 ? 5.59014   6.88070   -40.38088 1.000 33.02482 ? 542 GLU B CB  1 
ATOM   3527 C CG  . GLU B 1 190 ? 4.85419   7.16312   -39.07961 1.000 33.03284 ? 542 GLU B CG  1 
ATOM   3528 C CD  . GLU B 1 190 ? 3.71878   6.19307   -38.75448 1.000 29.80433 ? 542 GLU B CD  1 
ATOM   3529 O OE1 . GLU B 1 190 ? 3.50028   5.18997   -39.47146 1.000 30.85325 ? 542 GLU B OE1 1 
ATOM   3530 O OE2 . GLU B 1 190 ? 3.03092   6.44335   -37.74448 1.000 29.65773 ? 542 GLU B OE2 1 
ATOM   3531 N N   . CYS B 1 191 ? 7.68514   5.66785   -38.02216 1.000 30.93155 ? 543 CYS B N   1 
ATOM   3532 C CA  . CYS B 1 191 ? 8.74749   5.89520   -37.04481 1.000 31.67167 ? 543 CYS B CA  1 
ATOM   3533 C C   . CYS B 1 191 ? 10.03063  5.20065   -37.47425 1.000 33.24167 ? 543 CYS B C   1 
ATOM   3534 O O   . CYS B 1 191 ? 11.11548  5.79012   -37.41869 1.000 32.78746 ? 543 CYS B O   1 
ATOM   3535 C CB  . CYS B 1 191 ? 8.32482   5.40153   -35.65976 1.000 26.23167 ? 543 CYS B CB  1 
ATOM   3536 S SG  . CYS B 1 191 ? 6.66005   5.89266   -35.17980 1.000 33.52423 ? 543 CYS B SG  1 
ATOM   3537 N N   . ILE B 1 192 ? 9.91870   3.93576   -37.89301 1.000 33.59032 ? 544 ILE B N   1 
ATOM   3538 C CA  . ILE B 1 192 ? 11.07965  3.17136   -38.34181 1.000 35.16532 ? 544 ILE B CA  1 
ATOM   3539 C C   . ILE B 1 192 ? 11.65397  3.77495   -39.61824 1.000 34.99765 ? 544 ILE B C   1 
ATOM   3540 O O   . ILE B 1 192 ? 12.86854  3.97532   -39.74215 1.000 40.94553 ? 544 ILE B O   1 
ATOM   3541 C CB  . ILE B 1 192 ? 10.68851  1.69425   -38.54537 1.000 40.18417 ? 544 ILE B CB  1 
ATOM   3542 C CG1 . ILE B 1 192 ? 9.91655   1.16695   -37.33056 1.000 37.88260 ? 544 ILE B CG1 1 
ATOM   3543 C CG2 . ILE B 1 192 ? 11.91454  0.83174   -38.78130 1.000 37.58157 ? 544 ILE B CG2 1 
ATOM   3544 C CD1 . ILE B 1 192 ? 10.75426  1.11647   -36.07705 1.000 40.80030 ? 544 ILE B CD1 1 
ATOM   3545 N N   . ASN B 1 193 ? 10.78698  4.08426   -40.58393 1.000 37.02316 ? 545 ASN B N   1 
ATOM   3546 C CA  . ASN B 1 193 ? 11.25410  4.49556   -41.90592 1.000 41.29933 ? 545 ASN B CA  1 
ATOM   3547 C C   . ASN B 1 193 ? 11.65171  5.96867   -41.95081 1.000 38.09318 ? 545 ASN B C   1 
ATOM   3548 O O   . ASN B 1 193 ? 12.63831  6.31824   -42.60422 1.000 40.18471 ? 545 ASN B O   1 
ATOM   3549 C CB  . ASN B 1 193 ? 10.17900  4.21068   -42.95883 1.000 39.02026 ? 545 ASN B CB  1 
ATOM   3550 C CG  . ASN B 1 193 ? 9.84998   2.73066   -43.07676 1.000 42.50225 ? 545 ASN B CG  1 
ATOM   3551 O OD1 . ASN B 1 193 ? 10.68307  1.86896   -42.78781 1.000 45.28483 ? 545 ASN B OD1 1 
ATOM   3552 N ND2 . ASN B 1 193 ? 8.62867   2.43149   -43.50500 1.000 40.44976 ? 545 ASN B ND2 1 
ATOM   3553 N N   . TYR B 1 194 ? 10.91236  6.84726   -41.26894 1.000 31.49246 ? 546 TYR B N   1 
ATOM   3554 C CA  . TYR B 1 194 ? 11.11981  8.28587   -41.40413 1.000 34.57926 ? 546 TYR B CA  1 
ATOM   3555 C C   . TYR B 1 194 ? 11.42362  9.01434   -40.10462 1.000 38.38516 ? 546 TYR B C   1 
ATOM   3556 O O   . TYR B 1 194 ? 11.55273  10.24618  -40.13246 1.000 36.52384 ? 546 TYR B O   1 
ATOM   3557 C CB  . TYR B 1 194 ? 9.89080   8.94382   -42.04674 1.000 41.03134 ? 546 TYR B CB  1 
ATOM   3558 C CG  . TYR B 1 194 ? 9.58062   8.43892   -43.43955 1.000 51.60523 ? 546 TYR B CG  1 
ATOM   3559 C CD1 . TYR B 1 194 ? 10.31156  8.88024   -44.53789 1.000 48.66409 ? 546 TYR B CD1 1 
ATOM   3560 C CD2 . TYR B 1 194 ? 8.55532   7.52188   -43.65650 1.000 51.99140 ? 546 TYR B CD2 1 
ATOM   3561 C CE1 . TYR B 1 194 ? 10.02883  8.42010   -45.81377 1.000 57.94985 ? 546 TYR B CE1 1 
ATOM   3562 C CE2 . TYR B 1 194 ? 8.26447   7.05704   -44.92538 1.000 48.35904 ? 546 TYR B CE2 1 
ATOM   3563 C CZ  . TYR B 1 194 ? 9.00575   7.50624   -46.00156 1.000 59.60111 ? 546 TYR B CZ  1 
ATOM   3564 O OH  . TYR B 1 194 ? 8.72007   7.04275   -47.26806 1.000 59.85011 ? 546 TYR B OH  1 
ATOM   3565 N N   . TYR B 1 195 ? 11.53566  8.30331   -38.97538 1.000 36.19544 ? 547 TYR B N   1 
ATOM   3566 C CA  . TYR B 1 195 ? 11.78787  8.90958   -37.66102 1.000 33.52093 ? 547 TYR B CA  1 
ATOM   3567 C C   . TYR B 1 195 ? 10.73344  9.96328   -37.30666 1.000 39.22414 ? 547 TYR B C   1 
ATOM   3568 O O   . TYR B 1 195 ? 11.03471  10.97888  -36.66681 1.000 36.34972 ? 547 TYR B O   1 
ATOM   3569 C CB  . TYR B 1 195 ? 13.19182  9.52381   -37.58297 1.000 39.80427 ? 547 TYR B CB  1 
ATOM   3570 C CG  . TYR B 1 195 ? 14.31081  8.73108   -38.22726 1.000 62.52833 ? 547 TYR B CG  1 
ATOM   3571 C CD1 . TYR B 1 195 ? 14.58542  8.85882   -39.59146 1.000 64.03062 ? 547 TYR B CD1 1 
ATOM   3572 C CD2 . TYR B 1 195 ? 15.12909  7.89432   -37.46673 1.000 65.74449 ? 547 TYR B CD2 1 
ATOM   3573 C CE1 . TYR B 1 195 ? 15.61793  8.15756   -40.18836 1.000 60.84051 ? 547 TYR B CE1 1 
ATOM   3574 C CE2 . TYR B 1 195 ? 16.17130  7.18512   -38.05313 1.000 72.86209 ? 547 TYR B CE2 1 
ATOM   3575 C CZ  . TYR B 1 195 ? 16.40821  7.32233   -39.41675 1.000 82.38481 ? 547 TYR B CZ  1 
ATOM   3576 O OH  . TYR B 1 195 ? 17.43513  6.62434   -40.01280 1.000 89.84989 ? 547 TYR B OH  1 
ATOM   3577 N N   . LYS B 1 196 ? 9.48545   9.72362   -37.71490 1.000 33.96748 ? 548 LYS B N   1 
ATOM   3578 C CA  . LYS B 1 196 ? 8.39652   10.68128  -37.55144 1.000 33.71722 ? 548 LYS B CA  1 
ATOM   3579 C C   . LYS B 1 196 ? 7.37585   10.14476  -36.54738 1.000 32.02314 ? 548 LYS B C   1 
ATOM   3580 O O   . LYS B 1 196 ? 6.76813   9.09369   -36.77569 1.000 29.98065 ? 548 LYS B O   1 
ATOM   3581 C CB  . LYS B 1 196 ? 7.72646   10.96670  -38.89806 1.000 37.22403 ? 548 LYS B CB  1 
ATOM   3582 C CG  . LYS B 1 196 ? 8.62334   11.65215  -39.91288 1.000 46.03798 ? 548 LYS B CG  1 
ATOM   3583 C CD  . LYS B 1 196 ? 7.91777   11.81760  -41.25498 1.000 42.91117 ? 548 LYS B CD  1 
ATOM   3584 C CE  . LYS B 1 196 ? 6.58452   12.52794  -41.10610 1.000 48.61767 ? 548 LYS B CE  1 
ATOM   3585 N NZ  . LYS B 1 196 ? 5.95220   12.78137  -42.43315 1.000 56.63273 ? 548 LYS B NZ  1 
ATOM   3586 N N   . PHE B 1 197 ? 7.13556   10.90195  -35.47651 1.000 28.25903 ? 549 PHE B N   1 
ATOM   3587 C CA  . PHE B 1 197 ? 6.32704   10.44970  -34.34356 1.000 26.54764 ? 549 PHE B CA  1 
ATOM   3588 C C   . PHE B 1 197 ? 5.12308   11.36533  -34.15256 1.000 32.99339 ? 549 PHE B C   1 
ATOM   3589 O O   . PHE B 1 197 ? 5.27351   12.56387  -33.88944 1.000 31.24362 ? 549 PHE B O   1 
ATOM   3590 C CB  . PHE B 1 197 ? 7.18960   10.40828  -33.07764 1.000 24.31687 ? 549 PHE B CB  1 
ATOM   3591 C CG  . PHE B 1 197 ? 8.29934   9.40077   -33.14026 1.000 35.88810 ? 549 PHE B CG  1 
ATOM   3592 C CD1 . PHE B 1 197 ? 9.53787   9.73437   -33.69575 1.000 32.89864 ? 549 PHE B CD1 1 
ATOM   3593 C CD2 . PHE B 1 197 ? 8.11517   8.11972   -32.63870 1.000 32.45673 ? 549 PHE B CD2 1 
ATOM   3594 C CE1 . PHE B 1 197 ? 10.55984  8.80915   -33.75929 1.000 29.30724 ? 549 PHE B CE1 1 
ATOM   3595 C CE2 . PHE B 1 197 ? 9.14572   7.18599   -32.68645 1.000 34.01777 ? 549 PHE B CE2 1 
ATOM   3596 C CZ  . PHE B 1 197 ? 10.37181  7.53298   -33.24640 1.000 33.60417 ? 549 PHE B CZ  1 
ATOM   3597 N N   . SER B 1 198 ? 3.93291   10.80554  -34.28487 1.000 31.11328 ? 550 SER B N   1 
ATOM   3598 C CA  . SER B 1 198 ? 2.69706   11.54976  -34.16338 1.000 36.78864 ? 550 SER B CA  1 
ATOM   3599 C C   . SER B 1 198 ? 1.84007   10.85645  -33.13100 1.000 31.69080 ? 550 SER B C   1 
ATOM   3600 O O   . SER B 1 198 ? 2.16586   9.75762   -32.67058 1.000 32.74529 ? 550 SER B O   1 
ATOM   3601 C CB  . SER B 1 198 ? 1.92787   11.59517  -35.48735 1.000 35.73228 ? 550 SER B CB  1 
ATOM   3602 O OG  . SER B 1 198 ? 1.58758   10.26352  -35.87102 1.000 27.46793 ? 550 SER B OG  1 
ATOM   3603 N N   . SER B 1 199 ? 0.70063   11.48237  -32.81107 1.000 29.06275 ? 551 SER B N   1 
ATOM   3604 C CA  . SER B 1 199 ? -0.29680  10.77584  -32.02121 1.000 27.68120 ? 551 SER B CA  1 
ATOM   3605 C C   . SER B 1 199 ? -0.74638  9.50542   -32.72804 1.000 28.40471 ? 551 SER B C   1 
ATOM   3606 O O   . SER B 1 199 ? -1.01876  8.49719   -32.06745 1.000 25.77065 ? 551 SER B O   1 
ATOM   3607 C CB  . SER B 1 199 ? -1.48597  11.68607  -31.70451 1.000 30.81157 ? 551 SER B CB  1 
ATOM   3608 O OG  . SER B 1 199 ? -1.14384  12.57357  -30.63999 1.000 30.90447 ? 551 SER B OG  1 
ATOM   3609 N N   . LYS B 1 200 ? -0.77940  9.51576   -34.06857 1.000 29.32384 ? 552 LYS B N   1 
ATOM   3610 C CA  . LYS B 1 200 ? -1.11242  8.29356   -34.80629 1.000 24.19140 ? 552 LYS B CA  1 
ATOM   3611 C C   . LYS B 1 200 ? -0.08668  7.19764   -34.56159 1.000 27.36781 ? 552 LYS B C   1 
ATOM   3612 O O   . LYS B 1 200 ? -0.42923  6.00819   -34.55459 1.000 27.11108 ? 552 LYS B O   1 
ATOM   3613 C CB  . LYS B 1 200 ? -1.21357  8.57728   -36.30593 1.000 34.12750 ? 552 LYS B CB  1 
ATOM   3614 C CG  . LYS B 1 200 ? -2.32473  9.52803   -36.72547 1.000 32.14097 ? 552 LYS B CG  1 
ATOM   3615 C CD  . LYS B 1 200 ? -3.71346  8.99837   -36.40458 1.000 35.84793 ? 552 LYS B CD  1 
ATOM   3616 C CE  . LYS B 1 200 ? -4.80725  9.85519   -37.06860 1.000 33.96515 ? 552 LYS B CE  1 
ATOM   3617 N NZ  . LYS B 1 200 ? -4.73153  9.83642   -38.57787 1.000 44.29056 ? 552 LYS B NZ  1 
ATOM   3618 N N   . SER B 1 201 ? 1.19097   7.56181   -34.41411 1.000 25.44112 ? 553 SER B N   1 
ATOM   3619 C CA  . SER B 1 201 ? 2.15888   6.52362   -34.11300 1.000 28.32352 ? 553 SER B CA  1 
ATOM   3620 C C   . SER B 1 201 ? 1.97983   6.00617   -32.68569 1.000 29.37898 ? 553 SER B C   1 
ATOM   3621 O O   . SER B 1 201 ? 2.17153   4.81307   -32.44662 1.000 23.65129 ? 553 SER B O   1 
ATOM   3622 C CB  . SER B 1 201 ? 3.58157   7.02365   -34.40743 1.000 29.10102 ? 553 SER B CB  1 
ATOM   3623 O OG  . SER B 1 201 ? 4.06332   7.96301   -33.47622 1.000 41.42063 ? 553 SER B OG  1 
ATOM   3624 N N   . ASP B 1 202 ? 1.53844   6.85708   -31.74430 1.000 26.09508 ? 554 ASP B N   1 
ATOM   3625 C CA  . ASP B 1 202 ? 1.12571   6.35101   -30.43585 1.000 25.97170 ? 554 ASP B CA  1 
ATOM   3626 C C   . ASP B 1 202 ? -0.04941  5.38044   -30.55257 1.000 24.68611 ? 554 ASP B C   1 
ATOM   3627 O O   . ASP B 1 202 ? -0.16639  4.44759   -29.74246 1.000 22.16180 ? 554 ASP B O   1 
ATOM   3628 C CB  . ASP B 1 202 ? 0.75014   7.50305   -29.48813 1.000 24.90718 ? 554 ASP B CB  1 
ATOM   3629 C CG  . ASP B 1 202 ? 1.96237   8.25054   -28.92235 1.000 35.55376 ? 554 ASP B CG  1 
ATOM   3630 O OD1 . ASP B 1 202 ? 3.11189   7.74299   -28.96910 1.000 24.87285 ? 554 ASP B OD1 1 
ATOM   3631 O OD2 . ASP B 1 202 ? 1.75441   9.37345   -28.39573 1.000 27.58301 ? 554 ASP B OD2 1 
ATOM   3632 N N   . VAL B 1 203 ? -0.93179  5.58187   -31.54333 1.000 21.36710 ? 555 VAL B N   1 
ATOM   3633 C CA  . VAL B 1 203 ? -2.05995  4.67596   -31.72270 1.000 25.12004 ? 555 VAL B CA  1 
ATOM   3634 C C   . VAL B 1 203 ? -1.56749  3.30869   -32.15715 1.000 26.67886 ? 555 VAL B C   1 
ATOM   3635 O O   . VAL B 1 203 ? -2.07778  2.28661   -31.69646 1.000 23.22854 ? 555 VAL B O   1 
ATOM   3636 C CB  . VAL B 1 203 ? -3.08139  5.23675   -32.73531 1.000 22.30661 ? 555 VAL B CB  1 
ATOM   3637 C CG1 . VAL B 1 203 ? -4.13726  4.19464   -33.06175 1.000 23.71705 ? 555 VAL B CG1 1 
ATOM   3638 C CG2 . VAL B 1 203 ? -3.75768  6.48976   -32.18699 1.000 26.20579 ? 555 VAL B CG2 1 
ATOM   3639 N N   . TRP B 1 204 ? -0.55356  3.26626   -33.03414 1.000 22.77977 ? 556 TRP B N   1 
ATOM   3640 C CA  . TRP B 1 204 ? 0.02838   1.97577   -33.39238 1.000 18.93581 ? 556 TRP B CA  1 
ATOM   3641 C C   . TRP B 1 204 ? 0.56806   1.26963   -32.15300 1.000 23.42449 ? 556 TRP B C   1 
ATOM   3642 O O   . TRP B 1 204 ? 0.31925   0.07676   -31.94054 1.000 22.08859 ? 556 TRP B O   1 
ATOM   3643 C CB  . TRP B 1 204 ? 1.13264   2.17274   -34.43507 1.000 24.84117 ? 556 TRP B CB  1 
ATOM   3644 C CG  . TRP B 1 204 ? 1.78193   0.88674   -34.85175 1.000 29.49219 ? 556 TRP B CG  1 
ATOM   3645 C CD1 . TRP B 1 204 ? 2.57909   0.08233   -34.08027 1.000 28.13642 ? 556 TRP B CD1 1 
ATOM   3646 C CD2 . TRP B 1 204 ? 1.68249   0.25314   -36.12833 1.000 26.81484 ? 556 TRP B CD2 1 
ATOM   3647 N NE1 . TRP B 1 204 ? 2.97810   -1.01981  -34.80028 1.000 27.49813 ? 556 TRP B NE1 1 
ATOM   3648 C CE2 . TRP B 1 204 ? 2.43363   -0.94528  -36.05919 1.000 30.53048 ? 556 TRP B CE2 1 
ATOM   3649 C CE3 . TRP B 1 204 ? 1.02303   0.57227   -37.32493 1.000 24.90734 ? 556 TRP B CE3 1 
ATOM   3650 C CZ2 . TRP B 1 204 ? 2.55487   -1.81629  -37.14287 1.000 26.87329 ? 556 TRP B CZ2 1 
ATOM   3651 C CZ3 . TRP B 1 204 ? 1.14582   -0.30410  -38.40432 1.000 26.72874 ? 556 TRP B CZ3 1 
ATOM   3652 C CH2 . TRP B 1 204 ? 1.91468   -1.47540  -38.30577 1.000 28.27974 ? 556 TRP B CH2 1 
ATOM   3653 N N   . SER B 1 205 ? 1.32824   1.99934   -31.32775 1.000 24.20847 ? 557 SER B N   1 
ATOM   3654 C CA  . SER B 1 205 ? 1.86464   1.42968   -30.09405 1.000 22.24848 ? 557 SER B CA  1 
ATOM   3655 C C   . SER B 1 205 ? 0.75099   0.93685   -29.18450 1.000 24.61850 ? 557 SER B C   1 
ATOM   3656 O O   . SER B 1 205 ? 0.88107   -0.10463  -28.53481 1.000 22.65687 ? 557 SER B O   1 
ATOM   3657 C CB  . SER B 1 205 ? 2.70221   2.47198   -29.34937 1.000 27.60798 ? 557 SER B CB  1 
ATOM   3658 O OG  . SER B 1 205 ? 3.79370   2.90760   -30.13965 1.000 34.87763 ? 557 SER B OG  1 
ATOM   3659 N N   . PHE B 1 206 ? -0.33576  1.69874   -29.09929 1.000 25.83196 ? 558 PHE B N   1 
ATOM   3660 C CA  . PHE B 1 206 ? -1.48130  1.28613   -28.29273 1.000 23.65142 ? 558 PHE B CA  1 
ATOM   3661 C C   . PHE B 1 206 ? -2.01874  -0.06379  -28.74400 1.000 24.14239 ? 558 PHE B C   1 
ATOM   3662 O O   . PHE B 1 206 ? -2.46697  -0.86242  -27.91992 1.000 26.72097 ? 558 PHE B O   1 
ATOM   3663 C CB  . PHE B 1 206 ? -2.57626  2.34189   -28.36326 1.000 24.30465 ? 558 PHE B CB  1 
ATOM   3664 C CG  . PHE B 1 206 ? -3.76209  2.01454   -27.51947 1.000 24.59440 ? 558 PHE B CG  1 
ATOM   3665 C CD1 . PHE B 1 206 ? -3.67608  2.07863   -26.12240 1.000 27.33662 ? 558 PHE B CD1 1 
ATOM   3666 C CD2 . PHE B 1 206 ? -4.95081  1.61767   -28.10227 1.000 25.77849 ? 558 PHE B CD2 1 
ATOM   3667 C CE1 . PHE B 1 206 ? -4.78040  1.76829   -25.32134 1.000 32.23017 ? 558 PHE B CE1 1 
ATOM   3668 C CE2 . PHE B 1 206 ? -6.05315  1.29758   -27.30745 1.000 28.75526 ? 558 PHE B CE2 1 
ATOM   3669 C CZ  . PHE B 1 206 ? -5.96231  1.37245   -25.91569 1.000 30.93281 ? 558 PHE B CZ  1 
ATOM   3670 N N   . GLY B 1 207 ? -2.01492  -0.32771  -30.05339 1.000 26.49201 ? 559 GLY B N   1 
ATOM   3671 C CA  . GLY B 1 207 ? -2.43355  -1.63745  -30.52617 1.000 22.20278 ? 559 GLY B CA  1 
ATOM   3672 C C   . GLY B 1 207 ? -1.55617  -2.75777  -29.99667 1.000 22.32854 ? 559 GLY B C   1 
ATOM   3673 O O   . GLY B 1 207 ? -2.05009  -3.82397  -29.60628 1.000 26.39235 ? 559 GLY B O   1 
ATOM   3674 N N   . VAL B 1 208 ? -0.23629  -2.54585  -30.01135 1.000 25.96288 ? 560 VAL B N   1 
ATOM   3675 C CA  . VAL B 1 208 ? 0.68493   -3.49793  -29.40389 1.000 30.28194 ? 560 VAL B CA  1 
ATOM   3676 C C   . VAL B 1 208 ? 0.41557   -3.60660  -27.90630 1.000 25.75326 ? 560 VAL B C   1 
ATOM   3677 O O   . VAL B 1 208 ? 0.38836   -4.70623  -27.34690 1.000 25.50358 ? 560 VAL B O   1 
ATOM   3678 C CB  . VAL B 1 208 ? 2.14818   -3.08638  -29.69529 1.000 21.16442 ? 560 VAL B CB  1 
ATOM   3679 C CG1 . VAL B 1 208 ? 3.12845   -4.09461  -29.11276 1.000 25.36229 ? 560 VAL B CG1 1 
ATOM   3680 C CG2 . VAL B 1 208 ? 2.37078   -2.91826  -31.20525 1.000 24.94303 ? 560 VAL B CG2 1 
ATOM   3681 N N   . LEU B 1 209 ? 0.21240   -2.47007  -27.23204 1.000 21.82686 ? 561 LEU B N   1 
ATOM   3682 C CA  . LEU B 1 209 ? -0.11907  -2.50746  -25.80701 1.000 26.51241 ? 561 LEU B CA  1 
ATOM   3683 C C   . LEU B 1 209 ? -1.40700  -3.29457  -25.55456 1.000 27.59553 ? 561 LEU B C   1 
ATOM   3684 O O   . LEU B 1 209 ? -1.50582  -4.04293  -24.57167 1.000 25.76322 ? 561 LEU B O   1 
ATOM   3685 C CB  . LEU B 1 209 ? -0.23301  -1.07387  -25.25763 1.000 28.10637 ? 561 LEU B CB  1 
ATOM   3686 C CG  . LEU B 1 209 ? -0.60267  -0.85955  -23.78642 1.000 32.25617 ? 561 LEU B CG  1 
ATOM   3687 C CD1 . LEU B 1 209 ? -0.09365  0.49170   -23.33483 1.000 25.13149 ? 561 LEU B CD1 1 
ATOM   3688 C CD2 . LEU B 1 209 ? -2.12862  -0.93838  -23.55200 1.000 27.59245 ? 561 LEU B CD2 1 
ATOM   3689 N N   . MET B 1 210 ? -2.40836  -3.14210  -26.42723 1.000 22.30135 ? 562 MET B N   1 
ATOM   3690 C CA  . MET B 1 210 ? -3.61615  -3.95856  -26.29380 1.000 22.54844 ? 562 MET B CA  1 
ATOM   3691 C C   . MET B 1 210 ? -3.30382  -5.44031  -26.46132 1.000 25.41526 ? 562 MET B C   1 
ATOM   3692 O O   . MET B 1 210 ? -3.80599  -6.28331  -25.70436 1.000 28.18643 ? 562 MET B O   1 
ATOM   3693 C CB  . MET B 1 210 ? -4.66037  -3.53185  -27.32500 1.000 26.07936 ? 562 MET B CB  1 
ATOM   3694 C CG  . MET B 1 210 ? -5.42614  -2.26194  -26.96544 1.000 31.47163 ? 562 MET B CG  1 
ATOM   3695 S SD  . MET B 1 210 ? -6.82239  -2.07734  -28.10334 1.000 39.11609 ? 562 MET B SD  1 
ATOM   3696 C CE  . MET B 1 210 ? -6.02973  -1.44601  -29.54989 1.000 36.01372 ? 562 MET B CE  1 
ATOM   3697 N N   . TRP B 1 211 ? -2.48630  -5.77492  -27.46197 1.000 26.70352 ? 563 TRP B N   1 
ATOM   3698 C CA  . TRP B 1 211 ? -2.07119  -7.16239  -27.65409 1.000 23.96509 ? 563 TRP B CA  1 
ATOM   3699 C C   . TRP B 1 211 ? -1.37396  -7.69980  -26.41011 1.000 27.25501 ? 563 TRP B C   1 
ATOM   3700 O O   . TRP B 1 211 ? -1.64174  -8.82619  -25.97501 1.000 28.12461 ? 563 TRP B O   1 
ATOM   3701 C CB  . TRP B 1 211 ? -1.16701  -7.27313  -28.89343 1.000 23.52004 ? 563 TRP B CB  1 
ATOM   3702 C CG  . TRP B 1 211 ? -0.81268  -8.72612  -29.22842 1.000 27.44770 ? 563 TRP B CG  1 
ATOM   3703 C CD1 . TRP B 1 211 ? -1.43667  -9.55048  -30.13809 1.000 26.25919 ? 563 TRP B CD1 1 
ATOM   3704 C CD2 . TRP B 1 211 ? 0.21722   -9.50689  -28.62259 1.000 30.27753 ? 563 TRP B CD2 1 
ATOM   3705 N NE1 . TRP B 1 211 ? -0.84784  -10.80212 -30.12341 1.000 29.13251 ? 563 TRP B NE1 1 
ATOM   3706 C CE2 . TRP B 1 211 ? 0.17169   -10.79796 -29.20847 1.000 31.29559 ? 563 TRP B CE2 1 
ATOM   3707 C CE3 . TRP B 1 211 ? 1.17500   -9.24647  -27.63199 1.000 32.25891 ? 563 TRP B CE3 1 
ATOM   3708 C CZ2 . TRP B 1 211 ? 1.04522   -11.81454 -28.83578 1.000 36.67300 ? 563 TRP B CZ2 1 
ATOM   3709 C CZ3 . TRP B 1 211 ? 2.04603   -10.25756 -27.27223 1.000 32.34450 ? 563 TRP B CZ3 1 
ATOM   3710 C CH2 . TRP B 1 211 ? 1.97285   -11.52741 -27.86786 1.000 34.00420 ? 563 TRP B CH2 1 
ATOM   3711 N N   . GLU B 1 212 ? -0.44411  -6.92086  -25.83904 1.000 25.01916 ? 564 GLU B N   1 
ATOM   3712 C CA  . GLU B 1 212 ? 0.22242   -7.34653  -24.60311 1.000 28.59301 ? 564 GLU B CA  1 
ATOM   3713 C C   . GLU B 1 212 ? -0.78751  -7.61267  -23.49110 1.000 31.89886 ? 564 GLU B C   1 
ATOM   3714 O O   . GLU B 1 212 ? -0.67488  -8.60350  -22.75428 1.000 31.57123 ? 564 GLU B O   1 
ATOM   3715 C CB  . GLU B 1 212 ? 1.21241   -6.28609  -24.11803 1.000 24.53428 ? 564 GLU B CB  1 
ATOM   3716 C CG  . GLU B 1 212 ? 2.41244   -5.97258  -25.00887 1.000 31.24205 ? 564 GLU B CG  1 
ATOM   3717 C CD  . GLU B 1 212 ? 3.24991   -4.85786  -24.41344 1.000 36.38745 ? 564 GLU B CD  1 
ATOM   3718 O OE1 . GLU B 1 212 ? 2.91188   -3.66141  -24.63959 1.000 30.70025 ? 564 GLU B OE1 1 
ATOM   3719 O OE2 . GLU B 1 212 ? 4.22988   -5.17765  -23.69844 1.000 33.93397 ? 564 GLU B OE2 1 
ATOM   3720 N N   . ALA B 1 213 ? -1.75717  -6.70926  -23.32343 1.000 28.61329 ? 565 ALA B N   1 
ATOM   3721 C CA  . ALA B 1 213 ? -2.68802  -6.83027  -22.20233 1.000 30.87324 ? 565 ALA B CA  1 
ATOM   3722 C C   . ALA B 1 213 ? -3.53393  -8.08822  -22.32405 1.000 34.60894 ? 565 ALA B C   1 
ATOM   3723 O O   . ALA B 1 213 ? -3.70938  -8.82573  -21.34912 1.000 32.72116 ? 565 ALA B O   1 
ATOM   3724 C CB  . ALA B 1 213 ? -3.57999  -5.59819  -22.11103 1.000 30.56472 ? 565 ALA B CB  1 
ATOM   3725 N N   . PHE B 1 214 ? -4.07791  -8.34812  -23.51348 1.000 37.99647 ? 566 PHE B N   1 
ATOM   3726 C CA  . PHE B 1 214 ? -4.89274  -9.54380  -23.69661 1.000 34.22213 ? 566 PHE B CA  1 
ATOM   3727 C C   . PHE B 1 214 ? -4.06546  -10.81278 -23.78281 1.000 32.59993 ? 566 PHE B C   1 
ATOM   3728 O O   . PHE B 1 214 ? -4.63866  -11.90464 -23.70409 1.000 40.01769 ? 566 PHE B O   1 
ATOM   3729 C CB  . PHE B 1 214 ? -5.77599  -9.38672  -24.93479 1.000 28.16733 ? 566 PHE B CB  1 
ATOM   3730 C CG  . PHE B 1 214 ? -6.90983  -8.45456  -24.70586 1.000 37.11243 ? 566 PHE B CG  1 
ATOM   3731 C CD1 . PHE B 1 214 ? -8.04424  -8.88133  -24.02901 1.000 35.97975 ? 566 PHE B CD1 1 
ATOM   3732 C CD2 . PHE B 1 214 ? -6.81461  -7.12428  -25.08165 1.000 30.72605 ? 566 PHE B CD2 1 
ATOM   3733 C CE1 . PHE B 1 214 ? -9.07606  -7.99991  -23.77243 1.000 34.30663 ? 566 PHE B CE1 1 
ATOM   3734 C CE2 . PHE B 1 214 ? -7.84752  -6.24353  -24.83470 1.000 32.04425 ? 566 PHE B CE2 1 
ATOM   3735 C CZ  . PHE B 1 214 ? -8.97711  -6.67688  -24.17935 1.000 31.21080 ? 566 PHE B CZ  1 
ATOM   3736 N N   . SER B 1 215 ? -2.74022  -10.69843 -23.92168 1.000 35.23934 ? 567 SER B N   1 
ATOM   3737 C CA  . SER B 1 215 ? -1.82634  -11.82606 -23.78651 1.000 28.28185 ? 567 SER B CA  1 
ATOM   3738 C C   . SER B 1 215 ? -1.25486  -11.94782 -22.37478 1.000 37.58842 ? 567 SER B C   1 
ATOM   3739 O O   . SER B 1 215 ? -0.25397  -12.64526 -22.17896 1.000 31.01042 ? 567 SER B O   1 
ATOM   3740 C CB  . SER B 1 215 ? -0.69457  -11.71148 -24.80882 1.000 32.31722 ? 567 SER B CB  1 
ATOM   3741 O OG  . SER B 1 215 ? -1.22974  -11.57582 -26.12322 1.000 32.44206 ? 567 SER B OG  1 
ATOM   3742 N N   . TYR B 1 216 ? -1.86213  -11.26416 -21.40119 1.000 32.97056 ? 568 TYR B N   1 
ATOM   3743 C CA  . TYR B 1 216 ? -1.45604  -11.31630 -19.99237 1.000 41.86173 ? 568 TYR B CA  1 
ATOM   3744 C C   . TYR B 1 216 ? 0.02993   -11.02092 -19.82463 1.000 32.92436 ? 568 TYR B C   1 
ATOM   3745 O O   . TYR B 1 216 ? 0.74825   -11.67591 -19.06768 1.000 33.31614 ? 568 TYR B O   1 
ATOM   3746 C CB  . TYR B 1 216 ? -1.85546  -12.65130 -19.35351 1.000 38.78155 ? 568 TYR B CB  1 
ATOM   3747 C CG  . TYR B 1 216 ? -3.36871  -12.74870 -19.22945 1.000 35.42641 ? 568 TYR B CG  1 
ATOM   3748 C CD1 . TYR B 1 216 ? -4.02543  -12.29417 -18.09297 1.000 40.69752 ? 568 TYR B CD1 1 
ATOM   3749 C CD2 . TYR B 1 216 ? -4.13738  -13.25494 -20.27303 1.000 46.89703 ? 568 TYR B CD2 1 
ATOM   3750 C CE1 . TYR B 1 216 ? -5.41258  -12.35830 -17.99243 1.000 42.22976 ? 568 TYR B CE1 1 
ATOM   3751 C CE2 . TYR B 1 216 ? -5.51520  -13.32498 -20.18462 1.000 44.02193 ? 568 TYR B CE2 1 
ATOM   3752 C CZ  . TYR B 1 216 ? -6.14588  -12.87511 -19.04227 1.000 40.72758 ? 568 TYR B CZ  1 
ATOM   3753 O OH  . TYR B 1 216 ? -7.51221  -12.94339 -18.95876 1.000 40.39198 ? 568 TYR B OH  1 
ATOM   3754 N N   . GLY B 1 217 ? 0.49584   -10.00559 -20.53352 1.000 32.30458 ? 569 GLY B N   1 
ATOM   3755 C CA  . GLY B 1 217 ? 1.83653   -9.51876  -20.31691 1.000 30.21538 ? 569 GLY B CA  1 
ATOM   3756 C C   . GLY B 1 217 ? 2.92625   -10.23306 -21.07124 1.000 31.38037 ? 569 GLY B C   1 
ATOM   3757 O O   . GLY B 1 217 ? 4.09675   -10.05708 -20.73392 1.000 35.45260 ? 569 GLY B O   1 
ATOM   3758 N N   . GLN B 1 218 ? 2.59423   -11.01720 -22.09330 1.000 33.21823 ? 570 GLN B N   1 
ATOM   3759 C CA  . GLN B 1 218 ? 3.63585   -11.60710 -22.92590 1.000 36.14512 ? 570 GLN B CA  1 
ATOM   3760 C C   . GLN B 1 218 ? 4.28992   -10.54087 -23.79917 1.000 36.29625 ? 570 GLN B C   1 
ATOM   3761 O O   . GLN B 1 218 ? 3.68009   -9.52742  -24.13369 1.000 36.54959 ? 570 GLN B O   1 
ATOM   3762 C CB  . GLN B 1 218 ? 3.05950   -12.71761 -23.80095 1.000 34.09122 ? 570 GLN B CB  1 
ATOM   3763 C CG  . GLN B 1 218 ? 2.83387   -14.03852 -23.05772 1.000 47.11152 ? 570 GLN B CG  1 
ATOM   3764 C CD  . GLN B 1 218 ? 1.60200   -14.79181 -23.56640 1.000 63.76315 ? 570 GLN B CD  1 
ATOM   3765 O OE1 . GLN B 1 218 ? 0.70216   -15.12989 -22.78899 1.000 61.41955 ? 570 GLN B OE1 1 
ATOM   3766 N NE2 . GLN B 1 218 ? 1.55308   -15.04719 -24.87825 1.000 67.29143 ? 570 GLN B NE2 1 
ATOM   3767 N N   . LYS B 1 219 ? 5.54676   -10.77475 -24.16594 1.000 30.44582 ? 571 LYS B N   1 
ATOM   3768 C CA  . LYS B 1 219 ? 6.22058   -9.78392  -24.99956 1.000 35.65502 ? 571 LYS B CA  1 
ATOM   3769 C C   . LYS B 1 219 ? 5.77569   -9.92504  -26.45780 1.000 34.92407 ? 571 LYS B C   1 
ATOM   3770 O O   . LYS B 1 219 ? 5.57508   -11.04138 -26.94868 1.000 31.66290 ? 571 LYS B O   1 
ATOM   3771 C CB  . LYS B 1 219 ? 7.74656   -9.92406  -24.89960 1.000 31.78647 ? 571 LYS B CB  1 
ATOM   3772 C CG  . LYS B 1 219 ? 8.28166   -9.76202  -23.46755 1.000 35.38397 ? 571 LYS B CG  1 
ATOM   3773 C CD  . LYS B 1 219 ? 9.80576   -9.64904  -23.42828 1.000 41.83022 ? 571 LYS B CD  1 
ATOM   3774 C CE  . LYS B 1 219 ? 10.28396  -8.30704  -23.97546 1.000 63.57163 ? 571 LYS B CE  1 
ATOM   3775 N NZ  . LYS B 1 219 ? 11.77952  -8.19487  -23.99588 1.000 74.01050 ? 571 LYS B NZ  1 
ATOM   3776 N N   . PRO B 1 220 ? 5.62073   -8.81506  -27.17144 1.000 28.03011 ? 572 PRO B N   1 
ATOM   3777 C CA  . PRO B 1 220 ? 5.22436   -8.89526  -28.57849 1.000 29.81012 ? 572 PRO B CA  1 
ATOM   3778 C C   . PRO B 1 220 ? 6.37125   -9.37836  -29.45314 1.000 26.87965 ? 572 PRO B C   1 
ATOM   3779 O O   . PRO B 1 220 ? 7.54649   -9.23523  -29.12424 1.000 28.34838 ? 572 PRO B O   1 
ATOM   3780 C CB  . PRO B 1 220 ? 4.84002   -7.44861  -28.92233 1.000 34.64620 ? 572 PRO B CB  1 
ATOM   3781 C CG  . PRO B 1 220 ? 5.70902   -6.61665  -28.00407 1.000 30.03318 ? 572 PRO B CG  1 
ATOM   3782 C CD  . PRO B 1 220 ? 5.79152   -7.42264  -26.71435 1.000 27.10041 ? 572 PRO B CD  1 
ATOM   3783 N N   . TYR B 1 221 ? 5.99773   -9.94721  -30.59292 1.000 25.54781 ? 573 TYR B N   1 
ATOM   3784 C CA  . TYR B 1 221 ? 6.94103   -10.47800 -31.57750 1.000 31.01724 ? 573 TYR B CA  1 
ATOM   3785 C C   . TYR B 1 221 ? 8.02819   -11.31600 -30.91131 1.000 34.75995 ? 573 TYR B C   1 
ATOM   3786 O O   . TYR B 1 221 ? 9.23156   -11.09694 -31.11043 1.000 30.31049 ? 573 TYR B O   1 
ATOM   3787 C CB  . TYR B 1 221 ? 7.55890   -9.35600  -32.40170 1.000 26.27414 ? 573 TYR B CB  1 
ATOM   3788 C CG  . TYR B 1 221 ? 6.55004   -8.40677  -33.00217 1.000 28.83804 ? 573 TYR B CG  1 
ATOM   3789 C CD1 . TYR B 1 221 ? 5.91031   -8.69849  -34.20114 1.000 27.98425 ? 573 TYR B CD1 1 
ATOM   3790 C CD2 . TYR B 1 221 ? 6.26933   -7.19417  -32.38279 1.000 31.12188 ? 573 TYR B CD2 1 
ATOM   3791 C CE1 . TYR B 1 221 ? 4.99792   -7.80473  -34.76734 1.000 27.18715 ? 573 TYR B CE1 1 
ATOM   3792 C CE2 . TYR B 1 221 ? 5.35583   -6.30519  -32.93271 1.000 26.35949 ? 573 TYR B CE2 1 
ATOM   3793 C CZ  . TYR B 1 221 ? 4.74006   -6.60437  -34.11984 1.000 26.04977 ? 573 TYR B CZ  1 
ATOM   3794 O OH  . TYR B 1 221 ? 3.82791   -5.70611  -34.64633 1.000 27.09379 ? 573 TYR B OH  1 
ATOM   3795 N N   . ARG B 1 222 ? 7.58163   -12.28115 -30.10753 1.000 31.24415 ? 574 ARG B N   1 
ATOM   3796 C CA  . ARG B 1 222 ? 8.48821   -13.11345 -29.32793 1.000 33.03965 ? 574 ARG B CA  1 
ATOM   3797 C C   . ARG B 1 222 ? 9.53954   -13.74848 -30.22870 1.000 36.43836 ? 574 ARG B C   1 
ATOM   3798 O O   . ARG B 1 222 ? 9.21466   -14.35710 -31.25412 1.000 32.52913 ? 574 ARG B O   1 
ATOM   3799 C CB  . ARG B 1 222 ? 7.69366   -14.19633 -28.58287 1.000 34.61131 ? 574 ARG B CB  1 
ATOM   3800 C CG  . ARG B 1 222 ? 8.55508   -15.26252 -27.90246 1.000 44.23090 ? 574 ARG B CG  1 
ATOM   3801 C CD  . ARG B 1 222 ? 7.73528   -16.08403 -26.90629 1.000 43.49187 ? 574 ARG B CD  1 
ATOM   3802 N NE  . ARG B 1 222 ? 6.79658   -16.99303 -27.55369 1.000 39.47953 ? 574 ARG B NE  1 
ATOM   3803 C CZ  . ARG B 1 222 ? 5.73912   -17.52904 -26.95608 1.000 42.26803 ? 574 ARG B CZ  1 
ATOM   3804 N NH1 . ARG B 1 222 ? 5.40798   -17.21227 -25.70942 1.000 37.02783 ? 574 ARG B NH1 1 
ATOM   3805 N NH2 . ARG B 1 222 ? 4.99182   -18.40270 -27.62315 1.000 41.52887 ? 574 ARG B NH2 1 
ATOM   3806 N N   . GLY B 1 223 ? 10.80661  -13.55790 -29.85858 1.000 33.73198 ? 575 GLY B N   1 
ATOM   3807 C CA  . GLY B 1 223 ? 11.91029  -14.22462 -30.50961 1.000 39.88219 ? 575 GLY B CA  1 
ATOM   3808 C C   . GLY B 1 223 ? 12.31535  -13.68645 -31.86115 1.000 53.12968 ? 575 GLY B C   1 
ATOM   3809 O O   . GLY B 1 223 ? 13.06207  -14.36906 -32.57512 1.000 40.26660 ? 575 GLY B O   1 
ATOM   3810 N N   . MET B 1 224 ? 11.85255  -12.49663 -32.24756 1.000 34.04927 ? 576 MET B N   1 
ATOM   3811 C CA  . MET B 1 224 ? 12.20825  -11.90523 -33.53206 1.000 33.80835 ? 576 MET B CA  1 
ATOM   3812 C C   . MET B 1 224 ? 13.12280  -10.71314 -33.30589 1.000 37.14396 ? 576 MET B C   1 
ATOM   3813 O O   . MET B 1 224 ? 12.95234  -9.97223  -32.33296 1.000 32.27105 ? 576 MET B O   1 
ATOM   3814 C CB  . MET B 1 224 ? 10.96333  -11.44656 -34.31443 1.000 31.92236 ? 576 MET B CB  1 
ATOM   3815 C CG  . MET B 1 224 ? 9.87370   -12.48942 -34.40618 1.000 30.55810 ? 576 MET B CG  1 
ATOM   3816 S SD  . MET B 1 224 ? 8.38503   -11.87915 -35.21189 1.000 34.93713 ? 576 MET B SD  1 
ATOM   3817 C CE  . MET B 1 224 ? 9.02920   -11.42610 -36.83145 1.000 36.65960 ? 576 MET B CE  1 
ATOM   3818 N N   . LYS B 1 225 ? 14.08486  -10.53102 -34.20993 1.000 35.75980 ? 577 LYS B N   1 
ATOM   3819 C CA  . LYS B 1 225 ? 14.87041  -9.30541  -34.22182 1.000 44.47419 ? 577 LYS B CA  1 
ATOM   3820 C C   . LYS B 1 225 ? 14.03551  -8.15199  -34.77185 1.000 40.59480 ? 577 LYS B C   1 
ATOM   3821 O O   . LYS B 1 225 ? 13.07020  -8.35289  -35.51998 1.000 33.78435 ? 577 LYS B O   1 
ATOM   3822 C CB  . LYS B 1 225 ? 16.12710  -9.44431  -35.08737 1.000 43.75083 ? 577 LYS B CB  1 
ATOM   3823 C CG  . LYS B 1 225 ? 16.80599  -10.80354 -35.08470 1.000 49.37171 ? 577 LYS B CG  1 
ATOM   3824 C CD  . LYS B 1 225 ? 18.13535  -10.70657 -35.82678 1.000 59.18912 ? 577 LYS B CD  1 
ATOM   3825 C CE  . LYS B 1 225 ? 18.83690  -12.05305 -35.93007 1.000 68.89057 ? 577 LYS B CE  1 
ATOM   3826 N NZ  . LYS B 1 225 ? 18.59639  -12.71912 -37.24412 1.000 63.58050 ? 577 LYS B NZ  1 
ATOM   3827 N N   . GLY B 1 226 ? 14.44391  -6.93072  -34.40626 1.000 44.79156 ? 578 GLY B N   1 
ATOM   3828 C CA  . GLY B 1 226 ? 13.78312  -5.73609  -34.92014 1.000 40.12482 ? 578 GLY B CA  1 
ATOM   3829 C C   . GLY B 1 226 ? 13.67416  -5.71932  -36.43314 1.000 42.54669 ? 578 GLY B C   1 
ATOM   3830 O O   . GLY B 1 226 ? 12.59969  -5.47508  -36.98616 1.000 35.24013 ? 578 GLY B O   1 
ATOM   3831 N N   . SER B 1 227 ? 14.78623  -5.99536  -37.12908 1.000 31.59717 ? 579 SER B N   1 
ATOM   3832 C CA  . SER B 1 227 ? 14.73939  -6.07458  -38.58777 1.000 36.43629 ? 579 SER B CA  1 
ATOM   3833 C C   . SER B 1 227 ? 13.70061  -7.08433  -39.06638 1.000 40.99889 ? 579 SER B C   1 
ATOM   3834 O O   . SER B 1 227 ? 13.06710  -6.88379  -40.10940 1.000 36.27627 ? 579 SER B O   1 
ATOM   3835 C CB  . SER B 1 227 ? 16.11542  -6.45399  -39.14146 1.000 46.88432 ? 579 SER B CB  1 
ATOM   3836 O OG  . SER B 1 227 ? 16.46457  -7.77312  -38.75048 1.000 46.96056 ? 579 SER B OG  1 
ATOM   3837 N N   . GLU B 1 228 ? 13.51270  -8.17244  -38.32647 1.000 32.51877 ? 580 GLU B N   1 
ATOM   3838 C CA  . GLU B 1 228 ? 12.54589  -9.17784  -38.74493 1.000 37.24906 ? 580 GLU B CA  1 
ATOM   3839 C C   . GLU B 1 228 ? 11.10877  -8.72191  -38.49581 1.000 27.51911 ? 580 GLU B C   1 
ATOM   3840 O O   . GLU B 1 228 ? 10.21798  -9.01810  -39.29962 1.000 34.89274 ? 580 GLU B O   1 
ATOM   3841 C CB  . GLU B 1 228 ? 12.83998  -10.49094 -38.02805 1.000 36.71150 ? 580 GLU B CB  1 
ATOM   3842 C CG  . GLU B 1 228 ? 14.17479  -11.08862 -38.43835 1.000 35.02399 ? 580 GLU B CG  1 
ATOM   3843 C CD  . GLU B 1 228 ? 14.53779  -12.30161 -37.62269 1.000 42.62545 ? 580 GLU B CD  1 
ATOM   3844 O OE1 . GLU B 1 228 ? 14.29724  -12.29502 -36.39897 1.000 40.40925 ? 580 GLU B OE1 1 
ATOM   3845 O OE2 . GLU B 1 228 ? 15.06776  -13.26475 -38.20910 1.000 55.22367 ? 580 GLU B OE2 1 
ATOM   3846 N N   . VAL B 1 229 ? 10.87083  -8.02795  -37.38298 1.000 30.03374 ? 581 VAL B N   1 
ATOM   3847 C CA  . VAL B 1 229 ? 9.58213   -7.37123  -37.15281 1.000 36.14945 ? 581 VAL B CA  1 
ATOM   3848 C C   . VAL B 1 229 ? 9.25191   -6.42992  -38.30442 1.000 36.34553 ? 581 VAL B C   1 
ATOM   3849 O O   . VAL B 1 229 ? 8.14042   -6.45110  -38.85461 1.000 30.15393 ? 581 VAL B O   1 
ATOM   3850 C CB  . VAL B 1 229 ? 9.60236   -6.62488  -35.80482 1.000 31.79720 ? 581 VAL B CB  1 
ATOM   3851 C CG1 . VAL B 1 229 ? 8.33078   -5.79240  -35.62254 1.000 33.31108 ? 581 VAL B CG1 1 
ATOM   3852 C CG2 . VAL B 1 229 ? 9.74236   -7.61956  -34.65723 1.000 30.67486 ? 581 VAL B CG2 1 
ATOM   3853 N N   . THR B 1 230 ? 10.22592  -5.60561  -38.70141 1.000 36.27944 ? 582 THR B N   1 
ATOM   3854 C CA  . THR B 1 230 ? 9.98048   -4.57899  -39.71329 1.000 37.43703 ? 582 THR B CA  1 
ATOM   3855 C C   . THR B 1 230 ? 9.58262   -5.20785  -41.04461 1.000 38.73645 ? 582 THR B C   1 
ATOM   3856 O O   . THR B 1 230 ? 8.58390   -4.80620  -41.65800 1.000 37.96171 ? 582 THR B O   1 
ATOM   3857 C CB  . THR B 1 230 ? 11.21929  -3.67731  -39.86237 1.000 41.79409 ? 582 THR B CB  1 
ATOM   3858 O OG1 . THR B 1 230 ? 11.37782  -2.86946  -38.68648 1.000 35.27189 ? 582 THR B OG1 1 
ATOM   3859 C CG2 . THR B 1 230 ? 11.09220  -2.75269  -41.06891 1.000 45.44946 ? 582 THR B CG2 1 
ATOM   3860 N N   . ALA B 1 231 ? 10.32600  -6.23096  -41.48548 1.000 38.24887 ? 583 ALA B N   1 
ATOM   3861 C CA  . ALA B 1 231 ? 9.98644   -6.92015  -42.72920 1.000 37.40781 ? 583 ALA B CA  1 
ATOM   3862 C C   . ALA B 1 231 ? 8.61948   -7.59951  -42.64156 1.000 36.55090 ? 583 ALA B C   1 
ATOM   3863 O O   . ALA B 1 231 ? 7.86141   -7.61773  -43.61847 1.000 37.58572 ? 583 ALA B O   1 
ATOM   3864 C CB  . ALA B 1 231 ? 11.06185  -7.94973  -43.06439 1.000 39.26876 ? 583 ALA B CB  1 
ATOM   3865 N N   . MET B 1 232 ? 8.30508   -8.20218  -41.49413 1.000 31.30012 ? 584 MET B N   1 
ATOM   3866 C CA  . MET B 1 232 ? 6.99262   -8.82533  -41.32077 1.000 30.66805 ? 584 MET B CA  1 
ATOM   3867 C C   . MET B 1 232 ? 5.87871   -7.81917  -41.57822 1.000 29.22240 ? 584 MET B C   1 
ATOM   3868 O O   . MET B 1 232 ? 4.94358   -8.08485  -42.34510 1.000 31.86297 ? 584 MET B O   1 
ATOM   3869 C CB  . MET B 1 232 ? 6.88045   -9.41303  -39.90981 1.000 33.11725 ? 584 MET B CB  1 
ATOM   3870 C CG  . MET B 1 232 ? 5.51696   -10.03050 -39.56127 1.000 33.19021 ? 584 MET B CG  1 
ATOM   3871 S SD  . MET B 1 232 ? 5.38104   -10.47322 -37.81864 1.000 34.73617 ? 584 MET B SD  1 
ATOM   3872 C CE  . MET B 1 232 ? 3.64835   -10.90716 -37.70557 1.000 36.19748 ? 584 MET B CE  1 
ATOM   3873 N N   . LEU B 1 233 ? 5.97006   -6.64373  -40.95338 1.000 31.56065 ? 585 LEU B N   1 
ATOM   3874 C CA  . LEU B 1 233 ? 4.90983   -5.65204  -41.10475 1.000 30.84998 ? 585 LEU B CA  1 
ATOM   3875 C C   . LEU B 1 233 ? 4.85391   -5.11410  -42.53211 1.000 30.47770 ? 585 LEU B C   1 
ATOM   3876 O O   . LEU B 1 233 ? 3.76459   -4.87371  -43.07106 1.000 26.33067 ? 585 LEU B O   1 
ATOM   3877 C CB  . LEU B 1 233 ? 5.11620   -4.52269  -40.09041 1.000 32.13430 ? 585 LEU B CB  1 
ATOM   3878 C CG  . LEU B 1 233 ? 5.15541   -4.98455  -38.63141 1.000 35.36514 ? 585 LEU B CG  1 
ATOM   3879 C CD1 . LEU B 1 233 ? 5.75654   -3.90662  -37.71251 1.000 24.88469 ? 585 LEU B CD1 1 
ATOM   3880 C CD2 . LEU B 1 233 ? 3.74236   -5.40576  -38.15484 1.000 27.15152 ? 585 LEU B CD2 1 
ATOM   3881 N N   . GLU B 1 234 ? 6.01707   -4.93245  -43.17079 1.000 30.96770 ? 586 GLU B N   1 
ATOM   3882 C CA  . GLU B 1 234 ? 6.02507   -4.43962  -44.54970 1.000 35.90729 ? 586 GLU B CA  1 
ATOM   3883 C C   . GLU B 1 234 ? 5.39515   -5.44517  -45.50894 1.000 31.16468 ? 586 GLU B C   1 
ATOM   3884 O O   . GLU B 1 234 ? 4.86951   -5.04902  -46.55574 1.000 32.41104 ? 586 GLU B O   1 
ATOM   3885 C CB  . GLU B 1 234 ? 7.45298   -4.10139  -44.99834 1.000 37.62217 ? 586 GLU B CB  1 
ATOM   3886 C CG  . GLU B 1 234 ? 8.14742   -3.05744  -44.13602 1.000 41.39133 ? 586 GLU B CG  1 
ATOM   3887 C CD  . GLU B 1 234 ? 7.76367   -1.63272  -44.48735 1.000 53.37850 ? 586 GLU B CD  1 
ATOM   3888 O OE1 . GLU B 1 234 ? 7.26178   -1.40753  -45.60999 1.000 63.14284 ? 586 GLU B OE1 1 
ATOM   3889 O OE2 . GLU B 1 234 ? 7.97689   -0.73585  -43.63866 1.000 52.62718 ? 586 GLU B OE2 1 
ATOM   3890 N N   . LYS B 1 235 ? 5.43619   -6.74602  -45.17483 1.000 31.09944 ? 587 LYS B N   1 
ATOM   3891 C CA  . LYS B 1 235 ? 4.72424   -7.76228  -45.94421 1.000 31.72183 ? 587 LYS B CA  1 
ATOM   3892 C C   . LYS B 1 235 ? 3.21743   -7.77971  -45.67611 1.000 32.27592 ? 587 LYS B C   1 
ATOM   3893 O O   . LYS B 1 235 ? 2.50850   -8.56860  -46.30808 1.000 35.88825 ? 587 LYS B O   1 
ATOM   3894 C CB  . LYS B 1 235 ? 5.29133   -9.15354  -45.65166 1.000 36.44259 ? 587 LYS B CB  1 
ATOM   3895 C CG  . LYS B 1 235 ? 6.57111   -9.47910  -46.40005 1.000 53.32924 ? 587 LYS B CG  1 
ATOM   3896 C CD  . LYS B 1 235 ? 6.93251   -10.95547 -46.24224 1.000 45.00589 ? 587 LYS B CD  1 
ATOM   3897 C CE  . LYS B 1 235 ? 7.14842   -11.31164 -44.77986 1.000 54.16730 ? 587 LYS B CE  1 
ATOM   3898 N NZ  . LYS B 1 235 ? 7.17514   -12.78392 -44.55878 1.000 53.20038 ? 587 LYS B NZ  1 
ATOM   3899 N N   . GLY B 1 236 ? 2.71594   -6.95008  -44.75922 1.000 28.94838 ? 588 GLY B N   1 
ATOM   3900 C CA  . GLY B 1 236 ? 1.30085   -6.96801  -44.41509 1.000 28.72034 ? 588 GLY B CA  1 
ATOM   3901 C C   . GLY B 1 236 ? 0.89281   -7.99576  -43.37887 1.000 31.77379 ? 588 GLY B C   1 
ATOM   3902 O O   . GLY B 1 236 ? -0.31118  -8.16379  -43.13875 1.000 29.83229 ? 588 GLY B O   1 
ATOM   3903 N N   . GLU B 1 237 ? 1.84509   -8.68513  -42.74471 1.000 26.79128 ? 589 GLU B N   1 
ATOM   3904 C CA  . GLU B 1 237 ? 1.50211   -9.61907  -41.68196 1.000 28.72953 ? 589 GLU B CA  1 
ATOM   3905 C C   . GLU B 1 237 ? 1.47604   -8.89223  -40.34207 1.000 28.91781 ? 589 GLU B C   1 
ATOM   3906 O O   . GLU B 1 237 ? 2.08861   -7.83093  -40.17318 1.000 29.64980 ? 589 GLU B O   1 
ATOM   3907 C CB  . GLU B 1 237 ? 2.48577   -10.79145 -41.63336 1.000 30.49892 ? 589 GLU B CB  1 
ATOM   3908 C CG  . GLU B 1 237 ? 2.49292   -11.65328 -42.88315 1.000 35.48557 ? 589 GLU B CG  1 
ATOM   3909 C CD  . GLU B 1 237 ? 3.65692   -12.65216 -42.91170 1.000 51.36400 ? 589 GLU B CD  1 
ATOM   3910 O OE1 . GLU B 1 237 ? 4.40361   -12.75929 -41.90954 1.000 50.74063 ? 589 GLU B OE1 1 
ATOM   3911 O OE2 . GLU B 1 237 ? 3.82347   -13.33900 -43.94104 1.000 53.05258 ? 589 GLU B OE2 1 
ATOM   3912 N N   . ARG B 1 238 ? 0.73094   -9.47241  -39.39691 1.000 29.78109 ? 590 ARG B N   1 
ATOM   3913 C CA  . ARG B 1 238 ? 0.50965   -8.91867  -38.06546 1.000 31.47281 ? 590 ARG B CA  1 
ATOM   3914 C C   . ARG B 1 238 ? 0.47251   -10.05923 -37.05390 1.000 29.37668 ? 590 ARG B C   1 
ATOM   3915 O O   . ARG B 1 238 ? 0.24812   -11.22172 -37.40872 1.000 26.90547 ? 590 ARG B O   1 
ATOM   3916 C CB  . ARG B 1 238 ? -0.80447  -8.13474  -37.98157 1.000 26.86163 ? 590 ARG B CB  1 
ATOM   3917 C CG  . ARG B 1 238 ? -0.98123  -7.03998  -39.02910 1.000 25.39177 ? 590 ARG B CG  1 
ATOM   3918 C CD  . ARG B 1 238 ? -0.15155  -5.80964  -38.68246 1.000 28.71204 ? 590 ARG B CD  1 
ATOM   3919 N NE  . ARG B 1 238 ? -0.37904  -4.68061  -39.58658 1.000 25.42660 ? 590 ARG B NE  1 
ATOM   3920 C CZ  . ARG B 1 238 ? 0.35906   -4.40123  -40.65246 1.000 29.26045 ? 590 ARG B CZ  1 
ATOM   3921 N NH1 . ARG B 1 238 ? 1.31292   -5.22919  -41.08311 1.000 27.57651 ? 590 ARG B NH1 1 
ATOM   3922 N NH2 . ARG B 1 238 ? 0.15893   -3.24979  -41.28978 1.000 23.65463 ? 590 ARG B NH2 1 
ATOM   3923 N N   . MET B 1 239 ? 0.71536   -9.71821  -35.78566 1.000 25.07740 ? 591 MET B N   1 
ATOM   3924 C CA  . MET B 1 239 ? 0.59252   -10.70233 -34.71894 1.000 23.80173 ? 591 MET B CA  1 
ATOM   3925 C C   . MET B 1 239 ? -0.81362  -11.28777 -34.71222 1.000 32.78874 ? 591 MET B C   1 
ATOM   3926 O O   . MET B 1 239 ? -1.78350  -10.60692 -35.04035 1.000 27.44529 ? 591 MET B O   1 
ATOM   3927 C CB  . MET B 1 239 ? 0.89828   -10.04696 -33.37327 1.000 26.33012 ? 591 MET B CB  1 
ATOM   3928 C CG  . MET B 1 239 ? 2.36867   -9.66517  -33.18796 1.000 28.73350 ? 591 MET B CG  1 
ATOM   3929 S SD  . MET B 1 239 ? 2.66061   -9.24438  -31.46137 1.000 35.19876 ? 591 MET B SD  1 
ATOM   3930 C CE  . MET B 1 239 ? 2.06135   -7.56246  -31.42522 1.000 29.79610 ? 591 MET B CE  1 
ATOM   3931 N N   . GLY B 1 240 ? -0.92204  -12.57357 -34.36483 1.000 29.38776 ? 592 GLY B N   1 
ATOM   3932 C CA  . GLY B 1 240 ? -2.21399  -13.22577 -34.32594 1.000 34.32074 ? 592 GLY B CA  1 
ATOM   3933 C C   . GLY B 1 240 ? -3.01602  -12.89621 -33.07862 1.000 25.95552 ? 592 GLY B C   1 
ATOM   3934 O O   . GLY B 1 240 ? -2.58734  -12.17438 -32.18451 1.000 31.31466 ? 592 GLY B O   1 
ATOM   3935 N N   . CYS B 1 241 ? -4.21096  -13.44887 -33.02673 1.000 30.16603 ? 593 CYS B N   1 
ATOM   3936 C CA  . CYS B 1 241 ? -5.12439  -13.16122 -31.92774 1.000 29.73064 ? 593 CYS B CA  1 
ATOM   3937 C C   . CYS B 1 241 ? -4.68923  -13.88746 -30.65597 1.000 38.79340 ? 593 CYS B C   1 
ATOM   3938 O O   . CYS B 1 241 ? -4.47682  -15.10630 -30.68697 1.000 35.66664 ? 593 CYS B O   1 
ATOM   3939 C CB  . CYS B 1 241 ? -6.53468  -13.58255 -32.33917 1.000 32.36492 ? 593 CYS B CB  1 
ATOM   3940 S SG  . CYS B 1 241 ? -7.83341  -13.09980 -31.19432 1.000 39.61703 ? 593 CYS B SG  1 
ATOM   3941 N N   . PRO B 1 242 ? -4.54538  -13.18703 -29.52582 1.000 35.74382 ? 594 PRO B N   1 
ATOM   3942 C CA  . PRO B 1 242 ? -4.19654  -13.87515 -28.27372 1.000 32.54887 ? 594 PRO B CA  1 
ATOM   3943 C C   . PRO B 1 242 ? -5.29755  -14.83439 -27.83524 1.000 35.15350 ? 594 PRO B C   1 
ATOM   3944 O O   . PRO B 1 242 ? -6.47902  -14.63888 -28.13013 1.000 34.97401 ? 594 PRO B O   1 
ATOM   3945 C CB  . PRO B 1 242 ? -4.01836  -12.72546 -27.26203 1.000 29.21526 ? 594 PRO B CB  1 
ATOM   3946 C CG  . PRO B 1 242 ? -3.78096  -11.47954 -28.11968 1.000 31.12676 ? 594 PRO B CG  1 
ATOM   3947 C CD  . PRO B 1 242 ? -4.62113  -11.71970 -29.35860 1.000 33.39083 ? 594 PRO B CD  1 
ATOM   3948 N N   . ALA B 1 243 ? -4.88359  -15.88367 -27.12506 1.000 42.61744 ? 595 ALA B N   1 
ATOM   3949 C CA  . ALA B 1 243 ? -5.81664  -16.89600 -26.64889 1.000 48.88646 ? 595 ALA B CA  1 
ATOM   3950 C C   . ALA B 1 243 ? -6.89437  -16.25260 -25.79169 1.000 41.34831 ? 595 ALA B C   1 
ATOM   3951 O O   . ALA B 1 243 ? -6.59698  -15.51340 -24.84703 1.000 46.00257 ? 595 ALA B O   1 
ATOM   3952 C CB  . ALA B 1 243 ? -5.07082  -17.97089 -25.85517 1.000 51.53258 ? 595 ALA B CB  1 
ATOM   3953 N N   . GLY B 1 244 ? -8.15044  -16.49477 -26.15996 1.000 38.44859 ? 596 GLY B N   1 
ATOM   3954 C CA  . GLY B 1 244 ? -9.27073  -15.96395 -25.41116 1.000 39.90276 ? 596 GLY B CA  1 
ATOM   3955 C C   . GLY B 1 244 ? -9.52246  -14.48428 -25.58011 1.000 43.36628 ? 596 GLY B C   1 
ATOM   3956 O O   . GLY B 1 244 ? -10.31524 -13.91704 -24.83003 1.000 44.80453 ? 596 GLY B O   1 
ATOM   3957 N N   . CYS B 1 245 ? -8.89132  -13.84189 -26.53572 1.000 35.74621 ? 597 CYS B N   1 
ATOM   3958 C CA  . CYS B 1 245 ? -9.11336  -12.41028 -26.71515 1.000 37.67467 ? 597 CYS B CA  1 
ATOM   3959 C C   . CYS B 1 245 ? -10.44487 -12.16396 -27.42681 1.000 40.07745 ? 597 CYS B C   1 
ATOM   3960 O O   . CYS B 1 245 ? -10.73441 -12.82683 -28.42281 1.000 42.49758 ? 597 CYS B O   1 
ATOM   3961 C CB  . CYS B 1 245 ? -7.95888  -11.80484 -27.51185 1.000 36.52945 ? 597 CYS B CB  1 
ATOM   3962 S SG  . CYS B 1 245 ? -8.16505  -10.07444 -27.90314 1.000 38.06876 ? 597 CYS B SG  1 
ATOM   3963 N N   . PRO B 1 246 ? -11.27386 -11.23215 -26.94738 1.000 37.99811 ? 598 PRO B N   1 
ATOM   3964 C CA  . PRO B 1 246 ? -12.52411 -10.92191 -27.65379 1.000 36.91124 ? 598 PRO B CA  1 
ATOM   3965 C C   . PRO B 1 246 ? -12.23622 -10.51092 -29.08857 1.000 42.55321 ? 598 PRO B C   1 
ATOM   3966 O O   . PRO B 1 246 ? -11.24179 -9.84484  -29.36883 1.000 30.19587 ? 598 PRO B O   1 
ATOM   3967 C CB  . PRO B 1 246 ? -13.10894 -9.75791  -26.84609 1.000 38.59379 ? 598 PRO B CB  1 
ATOM   3968 C CG  . PRO B 1 246 ? -12.44188 -9.85687  -25.49642 1.000 38.01892 ? 598 PRO B CG  1 
ATOM   3969 C CD  . PRO B 1 246 ? -11.08692 -10.39366 -25.75237 1.000 39.53097 ? 598 PRO B CD  1 
ATOM   3970 N N   . ARG B 1 247 ? -13.12113 -10.90979 -30.00195 1.000 33.86418 ? 599 ARG B N   1 
ATOM   3971 C CA  . ARG B 1 247 ? -12.83384 -10.70881 -31.41682 1.000 35.21460 ? 599 ARG B CA  1 
ATOM   3972 C C   . ARG B 1 247 ? -12.80262 -9.23181  -31.77462 1.000 35.77102 ? 599 ARG B C   1 
ATOM   3973 O O   . ARG B 1 247 ? -11.91540 -8.78772  -32.51796 1.000 32.54768 ? 599 ARG B O   1 
ATOM   3974 C CB  . ARG B 1 247 ? -13.86034 -11.43497 -32.28107 1.000 43.67719 ? 599 ARG B CB  1 
ATOM   3975 C CG  . ARG B 1 247 ? -13.69061 -11.16808 -33.76129 1.000 40.54419 ? 599 ARG B CG  1 
ATOM   3976 C CD  . ARG B 1 247 ? -12.36687 -11.71715 -34.27318 1.000 48.83128 ? 599 ARG B CD  1 
ATOM   3977 N NE  . ARG B 1 247 ? -12.26969 -11.61026 -35.72475 1.000 55.24607 ? 599 ARG B NE  1 
ATOM   3978 C CZ  . ARG B 1 247 ? -12.79517 -12.48317 -36.57697 1.000 56.89499 ? 599 ARG B CZ  1 
ATOM   3979 N NH1 . ARG B 1 247 ? -13.47850 -13.53797 -36.15466 1.000 47.72621 ? 599 ARG B NH1 1 
ATOM   3980 N NH2 . ARG B 1 247 ? -12.63192 -12.29236 -37.88533 1.000 44.54517 ? 599 ARG B NH2 1 
ATOM   3981 N N   . GLU B 1 248 ? -13.76210 -8.45670  -31.26187 1.000 30.36614 ? 600 GLU B N   1 
ATOM   3982 C CA  . GLU B 1 248 ? -13.78253 -7.02680  -31.54219 1.000 36.55368 ? 600 GLU B CA  1 
ATOM   3983 C C   . GLU B 1 248 ? -12.50617 -6.33579  -31.07541 1.000 34.47478 ? 600 GLU B C   1 
ATOM   3984 O O   . GLU B 1 248 ? -12.07406 -5.35705  -31.69508 1.000 31.61997 ? 600 GLU B O   1 
ATOM   3985 C CB  . GLU B 1 248 ? -15.00240 -6.37685  -30.88972 1.000 44.86893 ? 600 GLU B CB  1 
ATOM   3986 C CG  . GLU B 1 248 ? -16.33082 -6.72417  -31.55409 1.000 48.79753 ? 600 GLU B CG  1 
ATOM   3987 C CD  . GLU B 1 248 ? -16.89216 -8.07728  -31.12362 1.000 56.78632 ? 600 GLU B CD  1 
ATOM   3988 O OE1 . GLU B 1 248 ? -16.23775 -8.81426  -30.34568 1.000 50.30759 ? 600 GLU B OE1 1 
ATOM   3989 O OE2 . GLU B 1 248 ? -18.00996 -8.40394  -31.57289 1.000 72.37107 ? 600 GLU B OE2 1 
ATOM   3990 N N   . MET B 1 249 ? -11.89390 -6.82270  -29.99401 1.000 31.78690 ? 601 MET B N   1 
ATOM   3991 C CA  . MET B 1 249 ? -10.64896 -6.22036  -29.52276 1.000 35.22524 ? 601 MET B CA  1 
ATOM   3992 C C   . MET B 1 249 ? -9.47970  -6.56709  -30.42913 1.000 26.86090 ? 601 MET B C   1 
ATOM   3993 O O   . MET B 1 249 ? -8.58490  -5.73591  -30.63631 1.000 30.76912 ? 601 MET B O   1 
ATOM   3994 C CB  . MET B 1 249 ? -10.36311 -6.64971  -28.08846 1.000 32.07543 ? 601 MET B CB  1 
ATOM   3995 C CG  . MET B 1 249 ? -11.43338 -6.20075  -27.10082 1.000 28.86369 ? 601 MET B CG  1 
ATOM   3996 S SD  . MET B 1 249 ? -11.55160 -4.40622  -26.91595 1.000 34.97751 ? 601 MET B SD  1 
ATOM   3997 C CE  . MET B 1 249 ? -12.66671 -3.86499  -28.24371 1.000 35.90067 ? 601 MET B CE  1 
ATOM   3998 N N   . TYR B 1 250 ? -9.44056  -7.80085  -30.94676 1.000 31.82300 ? 602 TYR B N   1 
ATOM   3999 C CA  . TYR B 1 250 ? -8.40565  -8.12952  -31.91641 1.000 28.47376 ? 602 TYR B CA  1 
ATOM   4000 C C   . TYR B 1 250 ? -8.60213  -7.34616  -33.20934 1.000 33.58510 ? 602 TYR B C   1 
ATOM   4001 O O   . TYR B 1 250 ? -7.62331  -6.87307  -33.80296 1.000 27.66549 ? 602 TYR B O   1 
ATOM   4002 C CB  . TYR B 1 250 ? -8.35354  -9.64319  -32.18737 1.000 28.84057 ? 602 TYR B CB  1 
ATOM   4003 C CG  . TYR B 1 250 ? -7.23317  -10.00510 -33.14653 1.000 35.06758 ? 602 TYR B CG  1 
ATOM   4004 C CD1 . TYR B 1 250 ? -5.89475  -9.80551  -32.79059 1.000 28.05780 ? 602 TYR B CD1 1 
ATOM   4005 C CD2 . TYR B 1 250 ? -7.51052  -10.51233 -34.40898 1.000 31.49727 ? 602 TYR B CD2 1 
ATOM   4006 C CE1 . TYR B 1 250 ? -4.87880  -10.10459 -33.66259 1.000 28.15417 ? 602 TYR B CE1 1 
ATOM   4007 C CE2 . TYR B 1 250 ? -6.50051  -10.82600 -35.28430 1.000 35.43208 ? 602 TYR B CE2 1 
ATOM   4008 C CZ  . TYR B 1 250 ? -5.18981  -10.62766 -34.90491 1.000 32.11203 ? 602 TYR B CZ  1 
ATOM   4009 O OH  . TYR B 1 250 ? -4.18583  -10.92848 -35.77669 1.000 29.21892 ? 602 TYR B OH  1 
ATOM   4010 N N   . ASP B 1 251 ? -9.85694  -7.17150  -33.64931 1.000 29.78826 ? 603 ASP B N   1 
ATOM   4011 C CA  . ASP B 1 251 ? -10.12271 -6.30724  -34.79630 1.000 27.48739 ? 603 ASP B CA  1 
ATOM   4012 C C   . ASP B 1 251 ? -9.63879  -4.88453  -34.53984 1.000 30.43755 ? 603 ASP B C   1 
ATOM   4013 O O   . ASP B 1 251 ? -9.11847  -4.21932  -35.44642 1.000 31.38804 ? 603 ASP B O   1 
ATOM   4014 C CB  . ASP B 1 251 ? -11.62559 -6.28234  -35.12271 1.000 34.79060 ? 603 ASP B CB  1 
ATOM   4015 C CG  . ASP B 1 251 ? -12.16783 -7.63847  -35.51177 1.000 34.91323 ? 603 ASP B CG  1 
ATOM   4016 O OD1 . ASP B 1 251 ? -11.36625 -8.51283  -35.89438 1.000 32.96775 ? 603 ASP B OD1 1 
ATOM   4017 O OD2 . ASP B 1 251 ? -13.40448 -7.82382  -35.44016 1.000 37.72341 ? 603 ASP B OD2 1 
ATOM   4018 N N   . LEU B 1 252 ? -9.84083  -4.37630  -33.32125 1.000 29.80186 ? 604 LEU B N   1 
ATOM   4019 C CA  . LEU B 1 252 ? -9.39265  -3.01958  -33.03320 1.000 28.56337 ? 604 LEU B CA  1 
ATOM   4020 C C   . LEU B 1 252 ? -7.86368  -2.92590  -33.07988 1.000 29.25507 ? 604 LEU B C   1 
ATOM   4021 O O   . LEU B 1 252 ? -7.31426  -1.93081  -33.57054 1.000 28.00608 ? 604 LEU B O   1 
ATOM   4022 C CB  . LEU B 1 252 ? -9.92849  -2.56816  -31.67158 1.000 31.80926 ? 604 LEU B CB  1 
ATOM   4023 C CG  . LEU B 1 252 ? -9.49404  -1.18882  -31.17612 1.000 25.16892 ? 604 LEU B CG  1 
ATOM   4024 C CD1 . LEU B 1 252 ? -9.90290  -0.10299  -32.14495 1.000 31.48716 ? 604 LEU B CD1 1 
ATOM   4025 C CD2 . LEU B 1 252 ? -10.07628 -0.92328  -29.79241 1.000 33.86318 ? 604 LEU B CD2 1 
ATOM   4026 N N   . MET B 1 253 ? -7.16020  -3.96081  -32.59841 1.000 27.37131 ? 605 MET B N   1 
ATOM   4027 C CA  . MET B 1 253 ? -5.69670  -3.97990  -32.70565 1.000 30.61470 ? 605 MET B CA  1 
ATOM   4028 C C   . MET B 1 253 ? -5.25731  -3.85813  -34.15499 1.000 30.24582 ? 605 MET B C   1 
ATOM   4029 O O   . MET B 1 253 ? -4.32817  -3.10958  -34.47467 1.000 27.64079 ? 605 MET B O   1 
ATOM   4030 C CB  . MET B 1 253 ? -5.11829  -5.26928  -32.12160 1.000 25.06730 ? 605 MET B CB  1 
ATOM   4031 C CG  . MET B 1 253 ? -5.36723  -5.47725  -30.64764 1.000 24.99344 ? 605 MET B CG  1 
ATOM   4032 S SD  . MET B 1 253 ? -4.84460  -7.14828  -30.24581 1.000 31.34589 ? 605 MET B SD  1 
ATOM   4033 C CE  . MET B 1 253 ? -5.74800  -7.38528  -28.71563 1.000 30.48814 ? 605 MET B CE  1 
ATOM   4034 N N   . ASN B 1 254 ? -5.91547  -4.59020  -35.05069 1.000 29.63262 ? 606 ASN B N   1 
ATOM   4035 C CA  . ASN B 1 254 ? -5.53562  -4.52236  -36.45518 1.000 26.32629 ? 606 ASN B CA  1 
ATOM   4036 C C   . ASN B 1 254 ? -5.81615  -3.14758  -37.04285 1.000 27.06075 ? 606 ASN B C   1 
ATOM   4037 O O   . ASN B 1 254 ? -5.06679  -2.67932  -37.90657 1.000 26.61088 ? 606 ASN B O   1 
ATOM   4038 C CB  . ASN B 1 254 ? -6.25915  -5.61588  -37.23765 1.000 28.99158 ? 606 ASN B CB  1 
ATOM   4039 C CG  . ASN B 1 254 ? -5.42863  -6.86908  -37.36579 1.000 32.05535 ? 606 ASN B CG  1 
ATOM   4040 O OD1 . ASN B 1 254 ? -4.31386  -6.82182  -37.86831 1.000 30.74045 ? 606 ASN B OD1 1 
ATOM   4041 N ND2 . ASN B 1 254 ? -5.96427  -7.99937  -36.90518 1.000 38.49635 ? 606 ASN B ND2 1 
ATOM   4042 N N   . LEU B 1 255 ? -6.88690  -2.48807  -36.59818 1.000 26.34674 ? 607 LEU B N   1 
ATOM   4043 C CA  . LEU B 1 255 ? -7.12114  -1.11290  -37.02633 1.000 29.51026 ? 607 LEU B CA  1 
ATOM   4044 C C   . LEU B 1 255 ? -6.02451  -0.18227  -36.51340 1.000 31.16144 ? 607 LEU B C   1 
ATOM   4045 O O   . LEU B 1 255 ? -5.59415  0.73531   -37.22568 1.000 28.22328 ? 607 LEU B O   1 
ATOM   4046 C CB  . LEU B 1 255 ? -8.50199  -0.64766  -36.55776 1.000 29.13290 ? 607 LEU B CB  1 
ATOM   4047 C CG  . LEU B 1 255 ? -8.89280  0.74975   -37.04066 1.000 34.96851 ? 607 LEU B CG  1 
ATOM   4048 C CD1 . LEU B 1 255 ? -9.00196  0.80671   -38.56029 1.000 39.44595 ? 607 LEU B CD1 1 
ATOM   4049 C CD2 . LEU B 1 255 ? -10.18419 1.21170   -36.38510 1.000 35.04283 ? 607 LEU B CD2 1 
ATOM   4050 N N   . CYS B 1 256 ? -5.56121  -0.39957  -35.27819 1.000 27.04375 ? 608 CYS B N   1 
ATOM   4051 C CA  . CYS B 1 256 ? -4.43912  0.38542   -34.77337 1.000 29.39761 ? 608 CYS B CA  1 
ATOM   4052 C C   . CYS B 1 256 ? -3.19138  0.15306   -35.61232 1.000 25.20829 ? 608 CYS B C   1 
ATOM   4053 O O   . CYS B 1 256 ? -2.39730  1.07506   -35.81005 1.000 27.58996 ? 608 CYS B O   1 
ATOM   4054 C CB  . CYS B 1 256 ? -4.16761  0.05461   -33.29825 1.000 23.09105 ? 608 CYS B CB  1 
ATOM   4055 S SG  . CYS B 1 256 ? -5.46829  0.63730   -32.18083 1.000 28.38049 ? 608 CYS B SG  1 
ATOM   4056 N N   . TRP B 1 257 ? -3.01736  -1.06038  -36.13150 1.000 22.35887 ? 609 TRP B N   1 
ATOM   4057 C CA  . TRP B 1 257 ? -1.88016  -1.40263  -36.96944 1.000 21.28812 ? 609 TRP B CA  1 
ATOM   4058 C C   . TRP B 1 257 ? -2.12709  -1.07675  -38.43129 1.000 28.44722 ? 609 TRP B C   1 
ATOM   4059 O O   . TRP B 1 257 ? -1.63772  -1.79226  -39.30919 1.000 31.42843 ? 609 TRP B O   1 
ATOM   4060 C CB  . TRP B 1 257 ? -1.52672  -2.88257  -36.80688 1.000 26.68569 ? 609 TRP B CB  1 
ATOM   4061 C CG  . TRP B 1 257 ? -1.22102  -3.25579  -35.38862 1.000 25.89407 ? 609 TRP B CG  1 
ATOM   4062 C CD1 . TRP B 1 257 ? -0.68965  -2.45228  -34.43914 1.000 28.83657 ? 609 TRP B CD1 1 
ATOM   4063 C CD2 . TRP B 1 257 ? -1.44241  -4.52919  -34.76797 1.000 19.91927 ? 609 TRP B CD2 1 
ATOM   4064 N NE1 . TRP B 1 257 ? -0.55689  -3.14193  -33.25283 1.000 27.05293 ? 609 TRP B NE1 1 
ATOM   4065 C CE2 . TRP B 1 257 ? -1.01742  -4.42204  -33.43565 1.000 27.06503 ? 609 TRP B CE2 1 
ATOM   4066 C CE3 . TRP B 1 257 ? -1.95813  -5.74806  -35.21354 1.000 25.36971 ? 609 TRP B CE3 1 
ATOM   4067 C CZ2 . TRP B 1 257 ? -1.09438  -5.48912  -32.53624 1.000 25.70438 ? 609 TRP B CZ2 1 
ATOM   4068 C CZ3 . TRP B 1 257 ? -2.03658  -6.80960  -34.32399 1.000 28.46443 ? 609 TRP B CZ3 1 
ATOM   4069 C CH2 . TRP B 1 257 ? -1.59239  -6.67392  -32.99772 1.000 24.89795 ? 609 TRP B CH2 1 
ATOM   4070 N N   . THR B 1 258 ? -2.90422  -0.03737  -38.71158 1.000 28.25836 ? 610 THR B N   1 
ATOM   4071 C CA  . THR B 1 258 ? -3.06592  0.44332   -40.07679 1.000 27.97459 ? 610 THR B CA  1 
ATOM   4072 C C   . THR B 1 258 ? -1.74055  0.99385   -40.58331 1.000 28.21800 ? 610 THR B C   1 
ATOM   4073 O O   . THR B 1 258 ? -1.15949  1.89418   -39.97249 1.000 29.52706 ? 610 THR B O   1 
ATOM   4074 C CB  . THR B 1 258 ? -4.14744  1.51602   -40.13807 1.000 28.14719 ? 610 THR B CB  1 
ATOM   4075 O OG1 . THR B 1 258 ? -5.41758  0.92968   -39.81267 1.000 31.69506 ? 610 THR B OG1 1 
ATOM   4076 C CG2 . THR B 1 258 ? -4.20441  2.15052   -41.53802 1.000 28.57260 ? 610 THR B CG2 1 
ATOM   4077 N N   . TYR B 1 259 ? -1.27024  0.46618   -41.71321 1.000 23.58602 ? 611 TYR B N   1 
ATOM   4078 C CA  . TYR B 1 259 ? 0.01036   0.91449   -42.25458 1.000 29.43758 ? 611 TYR B CA  1 
ATOM   4079 C C   . TYR B 1 259 ? -0.00751  2.41140   -42.56788 1.000 36.97002 ? 611 TYR B C   1 
ATOM   4080 O O   . TYR B 1 259 ? 0.91634   3.14185   -42.19059 1.000 32.02046 ? 611 TYR B O   1 
ATOM   4081 C CB  . TYR B 1 259 ? 0.37933   0.11712   -43.50644 1.000 33.72162 ? 611 TYR B CB  1 
ATOM   4082 C CG  . TYR B 1 259 ? 1.83252   0.31980   -43.87397 1.000 32.64985 ? 611 TYR B CG  1 
ATOM   4083 C CD1 . TYR B 1 259 ? 2.22703   1.35728   -44.71412 1.000 36.07628 ? 611 TYR B CD1 1 
ATOM   4084 C CD2 . TYR B 1 259 ? 2.82054   -0.51027  -43.35025 1.000 31.96412 ? 611 TYR B CD2 1 
ATOM   4085 C CE1 . TYR B 1 259 ? 3.58067   1.54580   -45.03868 1.000 36.03317 ? 611 TYR B CE1 1 
ATOM   4086 C CE2 . TYR B 1 259 ? 4.15198   -0.33432  -43.67288 1.000 36.06003 ? 611 TYR B CE2 1 
ATOM   4087 C CZ  . TYR B 1 259 ? 4.52676   0.69593   -44.51218 1.000 38.27100 ? 611 TYR B CZ  1 
ATOM   4088 O OH  . TYR B 1 259 ? 5.87035   0.85683   -44.80690 1.000 41.11038 ? 611 TYR B OH  1 
ATOM   4089 N N   . ASP B 1 260 ? -1.03556  2.88272   -43.27427 1.000 28.67907 ? 612 ASP B N   1 
ATOM   4090 C CA  . ASP B 1 260 ? -1.06046  4.27450   -43.71283 1.000 35.10377 ? 612 ASP B CA  1 
ATOM   4091 C C   . ASP B 1 260 ? -1.43979  5.16721   -42.54162 1.000 31.57438 ? 612 ASP B C   1 
ATOM   4092 O O   . ASP B 1 260 ? -2.52641  5.02817   -41.97596 1.000 37.48291 ? 612 ASP B O   1 
ATOM   4093 C CB  . ASP B 1 260 ? -2.03903  4.46211   -44.87140 1.000 39.08953 ? 612 ASP B CB  1 
ATOM   4094 C CG  . ASP B 1 260 ? -1.87408  5.81544   -45.57416 1.000 48.64122 ? 612 ASP B CG  1 
ATOM   4095 O OD1 . ASP B 1 260 ? -1.28788  6.74597   -44.97774 1.000 55.67715 ? 612 ASP B OD1 1 
ATOM   4096 O OD2 . ASP B 1 260 ? -2.33390  5.94419   -46.72999 1.000 49.91470 ? 612 ASP B OD2 1 
ATOM   4097 N N   . VAL B 1 261 ? -0.55837  6.10787   -42.20422 1.000 31.39487 ? 613 VAL B N   1 
ATOM   4098 C CA  . VAL B 1 261 ? -0.76786  6.92931   -41.02314 1.000 39.38576 ? 613 VAL B CA  1 
ATOM   4099 C C   . VAL B 1 261 ? -2.02447  7.77823   -41.16781 1.000 40.68335 ? 613 VAL B C   1 
ATOM   4100 O O   . VAL B 1 261 ? -2.75671  7.97719   -40.19450 1.000 32.81034 ? 613 VAL B O   1 
ATOM   4101 C CB  . VAL B 1 261 ? 0.49628   7.76801   -40.74773 1.000 41.90936 ? 613 VAL B CB  1 
ATOM   4102 C CG1 . VAL B 1 261 ? 0.71586   8.81759   -41.84133 1.000 47.49889 ? 613 VAL B CG1 1 
ATOM   4103 C CG2 . VAL B 1 261 ? 0.42853   8.39571   -39.35983 1.000 36.40830 ? 613 VAL B CG2 1 
ATOM   4104 N N   . GLU B 1 262 ? -2.34146  8.22970   -42.38772 1.000 46.78704 ? 614 GLU B N   1 
ATOM   4105 C CA  . GLU B 1 262 ? -3.54066  9.04305   -42.58412 1.000 46.15287 ? 614 GLU B CA  1 
ATOM   4106 C C   . GLU B 1 262 ? -4.81839  8.23515   -42.40231 1.000 39.35610 ? 614 GLU B C   1 
ATOM   4107 O O   . GLU B 1 262 ? -5.83408  8.77378   -41.95062 1.000 44.02018 ? 614 GLU B O   1 
ATOM   4108 C CB  . GLU B 1 262 ? -3.51671  9.69415   -43.96946 1.000 48.18925 ? 614 GLU B CB  1 
ATOM   4109 C CG  . GLU B 1 262 ? -2.38220  10.68720  -44.14108 1.000 50.03316 ? 614 GLU B CG  1 
ATOM   4110 C CD  . GLU B 1 262 ? -2.37912  11.77240  -43.06777 1.000 60.80514 ? 614 GLU B CD  1 
ATOM   4111 O OE1 . GLU B 1 262 ? -3.47570  12.21340  -42.64878 1.000 63.19549 ? 614 GLU B OE1 1 
ATOM   4112 O OE2 . GLU B 1 262 ? -1.27531  12.17982  -42.64000 1.000 55.98479 ? 614 GLU B OE2 1 
ATOM   4113 N N   . ASN B 1 263 ? -4.79178  6.95269   -42.73456 1.000 34.82994 ? 615 ASN B N   1 
ATOM   4114 C CA  . ASN B 1 263 ? -5.95812  6.09568   -42.59132 1.000 38.81490 ? 615 ASN B CA  1 
ATOM   4115 C C   . ASN B 1 263 ? -6.09189  5.49268   -41.19660 1.000 36.13140 ? 615 ASN B C   1 
ATOM   4116 O O   . ASN B 1 263 ? -7.15782  4.97984   -40.85566 1.000 39.70499 ? 615 ASN B O   1 
ATOM   4117 C CB  . ASN B 1 263 ? -5.89925  4.98987   -43.65326 1.000 42.45694 ? 615 ASN B CB  1 
ATOM   4118 C CG  . ASN B 1 263 ? -5.90801  5.55485   -45.07380 1.000 46.23972 ? 615 ASN B CG  1 
ATOM   4119 O OD1 . ASN B 1 263 ? -4.99681  5.31268   -45.86301 1.000 56.60109 ? 615 ASN B OD1 1 
ATOM   4120 N ND2 . ASN B 1 263 ? -6.94008  6.32216   -45.39142 1.000 44.21972 ? 615 ASN B ND2 1 
ATOM   4121 N N   . ARG B 1 264 ? -5.05234  5.55650   -40.38219 1.000 32.81757 ? 616 ARG B N   1 
ATOM   4122 C CA  . ARG B 1 264 ? -5.11470  4.98207   -39.04311 1.000 31.27205 ? 616 ARG B CA  1 
ATOM   4123 C C   . ARG B 1 264 ? -5.96490  5.87774   -38.14395 1.000 30.23623 ? 616 ARG B C   1 
ATOM   4124 O O   . ARG B 1 264 ? -5.92271  7.10543   -38.27787 1.000 33.08714 ? 616 ARG B O   1 
ATOM   4125 C CB  . ARG B 1 264 ? -3.69399  4.86225   -38.48406 1.000 31.99767 ? 616 ARG B CB  1 
ATOM   4126 C CG  . ARG B 1 264 ? -3.50891  4.07681   -37.18923 1.000 26.33092 ? 616 ARG B CG  1 
ATOM   4127 C CD  . ARG B 1 264 ? -2.03384  4.19390   -36.75519 1.000 27.19005 ? 616 ARG B CD  1 
ATOM   4128 N NE  . ARG B 1 264 ? -1.11843  3.79373   -37.82001 1.000 26.39159 ? 616 ARG B NE  1 
ATOM   4129 C CZ  . ARG B 1 264 ? 0.10919   4.27592   -37.97602 1.000 25.12947 ? 616 ARG B CZ  1 
ATOM   4130 N NH1 . ARG B 1 264 ? 0.62826   5.14972   -37.12360 1.000 27.08800 ? 616 ARG B NH1 1 
ATOM   4131 N NH2 . ARG B 1 264 ? 0.81420   3.91393   -39.04078 1.000 26.90978 ? 616 ARG B NH2 1 
ATOM   4132 N N   . PRO B 1 265 ? -6.73753  5.30961   -37.22111 1.000 31.54514 ? 617 PRO B N   1 
ATOM   4133 C CA  . PRO B 1 265 ? -7.55503  6.15589   -36.33740 1.000 30.06626 ? 617 PRO B CA  1 
ATOM   4134 C C   . PRO B 1 265 ? -6.70917  6.96366   -35.35608 1.000 32.08486 ? 617 PRO B C   1 
ATOM   4135 O O   . PRO B 1 265 ? -5.58644  6.58659   -35.00374 1.000 33.14678 ? 617 PRO B O   1 
ATOM   4136 C CB  . PRO B 1 265 ? -8.44705  5.14796   -35.60063 1.000 29.14850 ? 617 PRO B CB  1 
ATOM   4137 C CG  . PRO B 1 265 ? -7.70145  3.81960   -35.68340 1.000 27.49269 ? 617 PRO B CG  1 
ATOM   4138 C CD  . PRO B 1 265 ? -6.97628  3.86767   -37.00759 1.000 27.78433 ? 617 PRO B CD  1 
ATOM   4139 N N   . GLY B 1 266 ? -7.25876  8.10798   -34.92903 1.000 27.89061 ? 618 GLY B N   1 
ATOM   4140 C CA  . GLY B 1 266 ? -6.76261  8.80302   -33.75725 1.000 36.31830 ? 618 GLY B CA  1 
ATOM   4141 C C   . GLY B 1 266 ? -7.32970  8.23245   -32.45282 1.000 32.85362 ? 618 GLY B C   1 
ATOM   4142 O O   . GLY B 1 266 ? -8.11256  7.28300   -32.43214 1.000 31.26153 ? 618 GLY B O   1 
ATOM   4143 N N   . PHE B 1 267 ? -6.91371  8.83023   -31.33065 1.000 28.31549 ? 619 PHE B N   1 
ATOM   4144 C CA  . PHE B 1 267 ? -7.36362  8.30346   -30.04671 1.000 27.15512 ? 619 PHE B CA  1 
ATOM   4145 C C   . PHE B 1 267 ? -8.81592  8.66054   -29.75497 1.000 30.61445 ? 619 PHE B C   1 
ATOM   4146 O O   . PHE B 1 267 ? -9.47750  7.93816   -29.00952 1.000 32.22190 ? 619 PHE B O   1 
ATOM   4147 C CB  . PHE B 1 267 ? -6.44754  8.77628   -28.91488 1.000 28.64609 ? 619 PHE B CB  1 
ATOM   4148 C CG  . PHE B 1 267 ? -5.21728  7.94351   -28.78241 1.000 29.74499 ? 619 PHE B CG  1 
ATOM   4149 C CD1 . PHE B 1 267 ? -5.31648  6.62246   -28.35492 1.000 27.85262 ? 619 PHE B CD1 1 
ATOM   4150 C CD2 . PHE B 1 267 ? -3.97074  8.45366   -29.10668 1.000 32.25837 ? 619 PHE B CD2 1 
ATOM   4151 C CE1 . PHE B 1 267 ? -4.19285  5.82564   -28.24751 1.000 27.77739 ? 619 PHE B CE1 1 
ATOM   4152 C CE2 . PHE B 1 267 ? -2.83687  7.66441   -28.99150 1.000 23.38983 ? 619 PHE B CE2 1 
ATOM   4153 C CZ  . PHE B 1 267 ? -2.94775  6.35711   -28.57037 1.000 25.10274 ? 619 PHE B CZ  1 
ATOM   4154 N N   . ALA B 1 268 ? -9.33811  9.74596   -30.33533 1.000 31.75302 ? 620 ALA B N   1 
ATOM   4155 C CA  . ALA B 1 268 ? -10.77685 9.99805   -30.22230 1.000 33.88748 ? 620 ALA B CA  1 
ATOM   4156 C C   . ALA B 1 268 ? -11.57903 8.79339   -30.71283 1.000 33.46303 ? 620 ALA B C   1 
ATOM   4157 O O   . ALA B 1 268 ? -12.44570 8.26276   -29.99842 1.000 31.65131 ? 620 ALA B O   1 
ATOM   4158 C CB  . ALA B 1 268 ? -11.15141 11.26334  -31.00341 1.000 36.67051 ? 620 ALA B CB  1 
ATOM   4159 N N   . ALA B 1 269 ? -11.27399 8.32158   -31.92386 1.000 36.13226 ? 621 ALA B N   1 
ATOM   4160 C CA  . ALA B 1 269 ? -12.01723 7.20090   -32.48632 1.000 35.17438 ? 621 ALA B CA  1 
ATOM   4161 C C   . ALA B 1 269 ? -11.72856 5.91648   -31.72578 1.000 30.48596 ? 621 ALA B C   1 
ATOM   4162 O O   . ALA B 1 269 ? -12.63792 5.10907   -31.50375 1.000 33.02886 ? 621 ALA B O   1 
ATOM   4163 C CB  . ALA B 1 269 ? -11.69012 7.03051   -33.97136 1.000 34.80634 ? 621 ALA B CB  1 
ATOM   4164 N N   . VAL B 1 270 ? -10.47548 5.72147   -31.29916 1.000 24.86062 ? 622 VAL B N   1 
ATOM   4165 C CA  . VAL B 1 270 ? -10.10590 4.51050   -30.55964 1.000 28.98394 ? 622 VAL B CA  1 
ATOM   4166 C C   . VAL B 1 270 ? -10.83025 4.46149   -29.22140 1.000 29.29588 ? 622 VAL B C   1 
ATOM   4167 O O   . VAL B 1 270 ? -11.38028 3.42381   -28.82771 1.000 31.01259 ? 622 VAL B O   1 
ATOM   4168 C CB  . VAL B 1 270 ? -8.57891  4.44403   -30.35921 1.000 34.09444 ? 622 VAL B CB  1 
ATOM   4169 C CG1 . VAL B 1 270 ? -8.22713  3.35260   -29.36470 1.000 35.02326 ? 622 VAL B CG1 1 
ATOM   4170 C CG2 . VAL B 1 270 ? -7.86181  4.23101   -31.70238 1.000 30.14262 ? 622 VAL B CG2 1 
ATOM   4171 N N   . GLU B 1 271 ? -10.79818 5.57727   -28.47900 1.000 28.13392 ? 623 GLU B N   1 
ATOM   4172 C CA  . GLU B 1 271 ? -11.51307 5.64442   -27.20958 1.000 29.18961 ? 623 GLU B CA  1 
ATOM   4173 C C   . GLU B 1 271 ? -12.99366 5.32710   -27.40381 1.000 31.23973 ? 623 GLU B C   1 
ATOM   4174 O O   . GLU B 1 271 ? -13.58956 4.59628   -26.60609 1.000 33.70852 ? 623 GLU B O   1 
ATOM   4175 C CB  . GLU B 1 271 ? -11.33846 7.03090   -26.58359 1.000 25.78621 ? 623 GLU B CB  1 
ATOM   4176 C CG  . GLU B 1 271 ? -11.86748 7.14701   -25.15652 1.000 26.42690 ? 623 GLU B CG  1 
ATOM   4177 C CD  . GLU B 1 271 ? -13.37073 7.39455   -25.10078 1.000 42.55285 ? 623 GLU B CD  1 
ATOM   4178 O OE1 . GLU B 1 271 ? -13.89392 8.05029   -26.02905 1.000 37.82718 ? 623 GLU B OE1 1 
ATOM   4179 O OE2 . GLU B 1 271 ? -14.02443 6.93158   -24.13663 1.000 38.05842 ? 623 GLU B OE2 1 
ATOM   4180 N N   . LEU B 1 272 ? -13.59656 5.86669   -28.46586 1.000 34.88075 ? 624 LEU B N   1 
ATOM   4181 C CA  . LEU B 1 272 ? -15.01023 5.61864   -28.73971 1.000 35.35063 ? 624 LEU B CA  1 
ATOM   4182 C C   . LEU B 1 272 ? -15.27811 4.13970   -28.99319 1.000 39.14274 ? 624 LEU B C   1 
ATOM   4183 O O   . LEU B 1 272 ? -16.24661 3.57229   -28.46415 1.000 39.22737 ? 624 LEU B O   1 
ATOM   4184 C CB  . LEU B 1 272 ? -15.45664 6.45914   -29.93511 1.000 32.03312 ? 624 LEU B CB  1 
ATOM   4185 C CG  . LEU B 1 272 ? -16.93094 6.30651   -30.31862 1.000 41.45498 ? 624 LEU B CG  1 
ATOM   4186 C CD1 . LEU B 1 272 ? -17.80165 6.61221   -29.11250 1.000 57.36790 ? 624 LEU B CD1 1 
ATOM   4187 C CD2 . LEU B 1 272 ? -17.27651 7.23006   -31.47354 1.000 50.85699 ? 624 LEU B CD2 1 
ATOM   4188 N N   . ARG B 1 273 ? -14.43476 3.49289   -29.80964 1.000 34.23323 ? 625 ARG B N   1 
ATOM   4189 C CA  . ARG B 1 273 ? -14.63855 2.07303   -30.07720 1.000 32.49055 ? 625 ARG B CA  1 
ATOM   4190 C C   . ARG B 1 273 ? -14.56766 1.25498   -28.79842 1.000 33.77017 ? 625 ARG B C   1 
ATOM   4191 O O   . ARG B 1 273 ? -15.32066 0.29007   -28.63124 1.000 34.91070 ? 625 ARG B O   1 
ATOM   4192 C CB  . ARG B 1 273 ? -13.60702 1.54429   -31.07256 1.000 28.49495 ? 625 ARG B CB  1 
ATOM   4193 C CG  . ARG B 1 273 ? -13.49421 2.32270   -32.36462 1.000 44.06283 ? 625 ARG B CG  1 
ATOM   4194 C CD  . ARG B 1 273 ? -14.56989 1.96023   -33.34871 1.000 52.20170 ? 625 ARG B CD  1 
ATOM   4195 N NE  . ARG B 1 273 ? -14.00626 1.66590   -34.66377 1.000 65.04093 ? 625 ARG B NE  1 
ATOM   4196 C CZ  . ARG B 1 273 ? -13.82585 0.44040   -35.13738 1.000 57.89901 ? 625 ARG B CZ  1 
ATOM   4197 N NH1 . ARG B 1 273 ? -14.14501 -0.62849  -34.42563 1.000 64.27176 ? 625 ARG B NH1 1 
ATOM   4198 N NH2 . ARG B 1 273 ? -13.32650 0.28343   -36.35920 1.000 64.24418 ? 625 ARG B NH2 1 
ATOM   4199 N N   . LEU B 1 274 ? -13.63569 1.59469   -27.90082 1.000 30.65626 ? 626 LEU B N   1 
ATOM   4200 C CA  . LEU B 1 274 ? -13.50622 0.84615   -26.65918 1.000 29.22591 ? 626 LEU B CA  1 
ATOM   4201 C C   . LEU B 1 274 ? -14.68499 1.10970   -25.73154 1.000 31.90115 ? 626 LEU B C   1 
ATOM   4202 O O   . LEU B 1 274 ? -15.15542 0.19547   -25.04494 1.000 33.95537 ? 626 LEU B O   1 
ATOM   4203 C CB  . LEU B 1 274 ? -12.19410 1.20995   -25.96489 1.000 28.57925 ? 626 LEU B CB  1 
ATOM   4204 C CG  . LEU B 1 274 ? -10.93299 0.58968   -26.56707 1.000 30.10064 ? 626 LEU B CG  1 
ATOM   4205 C CD1 . LEU B 1 274 ? -9.73265  1.32420   -26.03652 1.000 33.14917 ? 626 LEU B CD1 1 
ATOM   4206 C CD2 . LEU B 1 274 ? -10.86423 -0.89807  -26.20512 1.000 31.59630 ? 626 LEU B CD2 1 
ATOM   4207 N N   . ARG B 1 275 ? -15.15923 2.35630   -25.68289 1.000 28.43722 ? 627 ARG B N   1 
ATOM   4208 C CA  . ARG B 1 275 ? -16.31840 2.66357   -24.85120 1.000 34.79771 ? 627 ARG B CA  1 
ATOM   4209 C C   . ARG B 1 275 ? -17.55009 1.91803   -25.34916 1.000 40.69884 ? 627 ARG B C   1 
ATOM   4210 O O   . ARG B 1 275 ? -18.28959 1.31806   -24.55918 1.000 42.26969 ? 627 ARG B O   1 
ATOM   4211 C CB  . ARG B 1 275 ? -16.57818 4.17045   -24.83196 1.000 35.03823 ? 627 ARG B CB  1 
ATOM   4212 C CG  . ARG B 1 275 ? -17.56421 4.58952   -23.75068 1.000 39.00817 ? 627 ARG B CG  1 
ATOM   4213 C CD  . ARG B 1 275 ? -18.15775 5.93356   -24.06960 1.000 43.32160 ? 627 ARG B CD  1 
ATOM   4214 N NE  . ARG B 1 275 ? -17.14431 6.84255   -24.58954 1.000 53.81266 ? 627 ARG B NE  1 
ATOM   4215 C CZ  . ARG B 1 275 ? -17.40831 8.02051   -25.14242 1.000 62.54375 ? 627 ARG B CZ  1 
ATOM   4216 N NH1 . ARG B 1 275 ? -18.65173 8.46128   -25.27288 1.000 51.93737 ? 627 ARG B NH1 1 
ATOM   4217 N NH2 . ARG B 1 275 ? -16.40082 8.77756   -25.57215 1.000 43.93026 ? 627 ARG B NH2 1 
ATOM   4218 N N   . ASN B 1 276 ? -17.78598 1.94133   -26.66593 1.000 36.22210 ? 628 ASN B N   1 
ATOM   4219 C CA  . ASN B 1 276 ? -18.95517 1.24961   -27.20279 1.000 31.78947 ? 628 ASN B CA  1 
ATOM   4220 C C   . ASN B 1 276 ? -18.83556 -0.26264  -27.05448 1.000 44.36538 ? 628 ASN B C   1 
ATOM   4221 O O   . ASN B 1 276 ? -19.84980 -0.94171  -26.84734 1.000 45.54641 ? 628 ASN B O   1 
ATOM   4222 C CB  . ASN B 1 276 ? -19.17889 1.62862   -28.66623 1.000 43.08013 ? 628 ASN B CB  1 
ATOM   4223 C CG  . ASN B 1 276 ? -19.54023 3.09222   -28.83700 1.000 39.56266 ? 628 ASN B CG  1 
ATOM   4224 O OD1 . ASN B 1 276 ? -20.06258 3.71690   -27.92132 1.000 59.07769 ? 628 ASN B OD1 1 
ATOM   4225 N ND2 . ASN B 1 276 ? -19.25107 3.64600   -30.00384 1.000 48.84710 ? 628 ASN B ND2 1 
ATOM   4226 N N   . TYR B 1 277 ? -17.62333 -0.82006  -27.13558 1.000 35.46261 ? 629 TYR B N   1 
ATOM   4227 C CA  . TYR B 1 277 ? -17.53700 -2.26830  -26.97130 1.000 34.15330 ? 629 TYR B CA  1 
ATOM   4228 C C   . TYR B 1 277 ? -17.65264 -2.68182  -25.51157 1.000 46.78571 ? 629 TYR B C   1 
ATOM   4229 O O   . TYR B 1 277 ? -18.19257 -3.75897  -25.21978 1.000 43.14806 ? 629 TYR B O   1 
ATOM   4230 C CB  . TYR B 1 277 ? -16.24436 -2.84247  -27.55233 1.000 39.74447 ? 629 TYR B CB  1 
ATOM   4231 C CG  . TYR B 1 277 ? -16.26236 -4.34926  -27.48307 1.000 38.83397 ? 629 TYR B CG  1 
ATOM   4232 C CD1 . TYR B 1 277 ? -17.21568 -5.06932  -28.18334 1.000 42.31937 ? 629 TYR B CD1 1 
ATOM   4233 C CD2 . TYR B 1 277 ? -15.37701 -5.04614  -26.68553 1.000 41.41716 ? 629 TYR B CD2 1 
ATOM   4234 C CE1 . TYR B 1 277 ? -17.26962 -6.44191  -28.11311 1.000 48.44801 ? 629 TYR B CE1 1 
ATOM   4235 C CE2 . TYR B 1 277 ? -15.41534 -6.43075  -26.61656 1.000 46.46538 ? 629 TYR B CE2 1 
ATOM   4236 C CZ  . TYR B 1 277 ? -16.36616 -7.11808  -27.33342 1.000 50.58020 ? 629 TYR B CZ  1 
ATOM   4237 O OH  . TYR B 1 277 ? -16.42837 -8.49244  -27.27268 1.000 50.81429 ? 629 TYR B OH  1 
ATOM   4238 N N   . TYR B 1 278 ? -17.16450 -1.84825  -24.58715 1.000 37.50655 ? 630 TYR B N   1 
ATOM   4239 C CA  . TYR B 1 278 ? -17.33496 -2.15398  -23.17251 1.000 34.73024 ? 630 TYR B CA  1 
ATOM   4240 C C   . TYR B 1 278 ? -18.80873 -2.11533  -22.79197 1.000 41.28998 ? 630 TYR B C   1 
ATOM   4241 O O   . TYR B 1 278 ? -19.29638 -2.98325  -22.05949 1.000 41.03181 ? 630 TYR B O   1 
ATOM   4242 C CB  . TYR B 1 278 ? -16.53147 -1.17694  -22.31621 1.000 38.62285 ? 630 TYR B CB  1 
ATOM   4243 C CG  . TYR B 1 278 ? -16.59572 -1.50581  -20.83814 1.000 44.11309 ? 630 TYR B CG  1 
ATOM   4244 C CD1 . TYR B 1 278 ? -15.82530 -2.52583  -20.30219 1.000 36.52046 ? 630 TYR B CD1 1 
ATOM   4245 C CD2 . TYR B 1 278 ? -17.44524 -0.80873  -19.98533 1.000 49.11212 ? 630 TYR B CD2 1 
ATOM   4246 C CE1 . TYR B 1 278 ? -15.88473 -2.84032  -18.95011 1.000 48.57679 ? 630 TYR B CE1 1 
ATOM   4247 C CE2 . TYR B 1 278 ? -17.51441 -1.11550  -18.63392 1.000 56.58061 ? 630 TYR B CE2 1 
ATOM   4248 C CZ  . TYR B 1 278 ? -16.73015 -2.13155  -18.12081 1.000 52.98370 ? 630 TYR B CZ  1 
ATOM   4249 O OH  . TYR B 1 278 ? -16.79789 -2.44110  -16.77769 1.000 58.87918 ? 630 TYR B OH  1 
ATOM   4250 N N   . TYR B 1 279 ? -19.53587 -1.12287  -23.30673 1.000 39.05876 ? 631 TYR B N   1 
ATOM   4251 C CA  . TYR B 1 279 ? -20.96537 -1.00567  -23.02744 1.000 50.60808 ? 631 TYR B CA  1 
ATOM   4252 C C   . TYR B 1 279 ? -21.74384 -2.21826  -23.53965 1.000 54.30645 ? 631 TYR B C   1 
ATOM   4253 O O   . TYR B 1 279 ? -22.77412 -2.58353  -22.96016 1.000 52.06030 ? 631 TYR B O   1 
ATOM   4254 C CB  . TYR B 1 279 ? -21.47011 0.31109   -23.63141 1.000 39.80814 ? 631 TYR B CB  1 
ATOM   4255 C CG  . TYR B 1 279 ? -22.96857 0.49354   -23.74639 1.000 57.70857 ? 631 TYR B CG  1 
ATOM   4256 C CD1 . TYR B 1 279 ? -23.71085 1.00262   -22.68908 1.000 55.08769 ? 631 TYR B CD1 1 
ATOM   4257 C CD2 . TYR B 1 279 ? -23.63259 0.20700   -24.93794 1.000 61.65705 ? 631 TYR B CD2 1 
ATOM   4258 C CE1 . TYR B 1 279 ? -25.08436 1.19052   -22.80151 1.000 55.59431 ? 631 TYR B CE1 1 
ATOM   4259 C CE2 . TYR B 1 279 ? -24.99949 0.39441   -25.06262 1.000 56.45354 ? 631 TYR B CE2 1 
ATOM   4260 C CZ  . TYR B 1 279 ? -25.71851 0.88574   -23.98975 1.000 62.93364 ? 631 TYR B CZ  1 
ATOM   4261 O OH  . TYR B 1 279 ? -27.07776 1.07313   -24.10619 1.000 71.24105 ? 631 TYR B OH  1 
ATOM   4262 N N   . ASP B 1 280 ? -21.25153 -2.87578  -24.59585 1.000 51.28643 ? 632 ASP B N   1 
ATOM   4263 C CA  . ASP B 1 280 ? -21.88285 -4.09040  -25.10069 1.000 53.37710 ? 632 ASP B CA  1 
ATOM   4264 C C   . ASP B 1 280 ? -21.79963 -5.25353  -24.11747 1.000 58.34020 ? 632 ASP B C   1 
ATOM   4265 O O   . ASP B 1 280 ? -22.43205 -6.28767  -24.35677 1.000 50.88301 ? 632 ASP B O   1 
ATOM   4266 C CB  . ASP B 1 280 ? -21.26796 -4.49077  -26.44423 1.000 56.61991 ? 632 ASP B CB  1 
ATOM   4267 C CG  . ASP B 1 280 ? -21.63018 -3.52507  -27.56867 1.000 61.58484 ? 632 ASP B CG  1 
ATOM   4268 O OD1 . ASP B 1 280 ? -22.74505 -2.96088  -27.54176 1.000 64.38715 ? 632 ASP B OD1 1 
ATOM   4269 O OD2 . ASP B 1 280 ? -20.80253 -3.32619  -28.48227 1.000 64.29659 ? 632 ASP B OD2 1 
ATOM   4270 N N   . VAL B 1 281 ? -21.03171 -5.12374  -23.03670 1.000 67.52307 ? 633 VAL B N   1 
ATOM   4271 C CA  . VAL B 1 281 ? -21.20400 -5.99275  -21.87047 1.000 60.48341 ? 633 VAL B CA  1 
ATOM   4272 C C   . VAL B 1 281 ? -21.30057 -5.10595  -20.63726 1.000 59.92116 ? 633 VAL B C   1 
ATOM   4273 O O   . VAL B 1 281 ? -21.09146 -5.55355  -19.51298 1.000 62.54848 ? 633 VAL B O   1 
ATOM   4274 C CB  . VAL B 1 281 ? -20.07868 -7.01443  -21.72299 1.000 64.05467 ? 633 VAL B CB  1 
ATOM   4275 C CG1 . VAL B 1 281 ? -20.61670 -8.29128  -21.09806 1.000 64.00202 ? 633 VAL B CG1 1 
ATOM   4276 C CG2 . VAL B 1 281 ? -19.42519 -7.29683  -23.06534 1.000 60.17806 ? 633 VAL B CG2 1 
HETATM 4277 C C1  . XFB C 2 .   ? -6.94941  1.03879   35.55561  1.000 33.80773 ? 701 XFB A C1  1 
HETATM 4278 C C10 . XFB C 2 .   ? -10.62982 0.87752   32.33317  1.000 29.20616 ? 701 XFB A C10 1 
HETATM 4279 C C11 . XFB C 2 .   ? -10.77908 0.80472   30.81237  1.000 45.92095 ? 701 XFB A C11 1 
HETATM 4280 C C12 . XFB C 2 .   ? -11.79096 0.08422   31.72145  1.000 36.56598 ? 701 XFB A C12 1 
HETATM 4281 C C13 . XFB C 2 .   ? -7.47712  3.29732   36.06088  1.000 40.30275 ? 701 XFB A C13 1 
HETATM 4282 C C14 . XFB C 2 .   ? -5.33889  -3.93614  34.72833  1.000 29.50399 ? 701 XFB A C14 1 
HETATM 4283 C C15 . XFB C 2 .   ? -6.47844  -5.07360  33.05802  1.000 33.26646 ? 701 XFB A C15 1 
HETATM 4284 C C16 . XFB C 2 .   ? -5.67117  -6.15574  33.24186  1.000 31.92691 ? 701 XFB A C16 1 
HETATM 4285 C C17 . XFB C 2 .   ? -4.68209  -6.10288  34.17418  1.000 28.91044 ? 701 XFB A C17 1 
HETATM 4286 C C18 . XFB C 2 .   ? -8.44775  -4.22363  31.70454  1.000 31.78691 ? 701 XFB A C18 1 
HETATM 4287 C C19 . XFB C 2 .   ? -9.24347  -4.77982  30.71539  1.000 39.06741 ? 701 XFB A C19 1 
HETATM 4288 C C2  . XFB C 2 .   ? -5.89896  0.77795   36.38928  1.000 34.33268 ? 701 XFB A C2  1 
HETATM 4289 C C20 . XFB C 2 .   ? -8.79671  -6.07367  30.50594  1.000 34.09905 ? 701 XFB A C20 1 
HETATM 4290 C C21 . XFB C 2 .   ? -9.39066  -7.08212  29.50262  1.000 39.86712 ? 701 XFB A C21 1 
HETATM 4291 C C22 . XFB C 2 .   ? -10.46911 -4.16865  29.94208  1.000 40.50596 ? 701 XFB A C22 1 
HETATM 4292 C C23 . XFB C 2 .   ? -10.96164 -1.52476  27.79626  1.000 51.95165 ? 701 XFB A C23 1 
HETATM 4293 C C24 . XFB C 2 .   ? -9.52628  -1.67930  27.86010  1.000 50.23323 ? 701 XFB A C24 1 
HETATM 4294 C C25 . XFB C 2 .   ? -9.18521  -2.64564  28.92996  1.000 47.94212 ? 701 XFB A C25 1 
HETATM 4295 C C3  . XFB C 2 .   ? -5.31155  -0.47489  36.39316  1.000 29.72257 ? 701 XFB A C3  1 
HETATM 4296 C C4  . XFB C 2 .   ? -5.78021  -1.48121  35.52314  1.000 28.58908 ? 701 XFB A C4  1 
HETATM 4297 C C5  . XFB C 2 .   ? -6.88301  -1.23368  34.65183  1.000 26.41034 ? 701 XFB A C5  1 
HETATM 4298 C C6  . XFB C 2 .   ? -7.46988  0.04600   34.66729  1.000 30.05331 ? 701 XFB A C6  1 
HETATM 4299 C C7  . XFB C 2 .   ? -8.63331  2.00698   34.47103  1.000 32.48686 ? 701 XFB A C7  1 
HETATM 4300 C C8  . XFB C 2 .   ? -8.57328  0.71962   33.97189  1.000 33.23986 ? 701 XFB A C8  1 
HETATM 4301 C C9  . XFB C 2 .   ? -9.45808  0.06121   32.90357  1.000 33.16079 ? 701 XFB A C9  1 
HETATM 4302 N N1  . XFB C 2 .   ? -7.71486  2.04903   35.31199  1.000 34.35423 ? 701 XFB A N1  1 
HETATM 4303 N N2  . XFB C 2 .   ? -5.10067  -2.77730  35.58371  1.000 31.63517 ? 701 XFB A N2  1 
HETATM 4304 N N3  . XFB C 2 .   ? -6.32148  -3.98298  33.79905  1.000 34.01243 ? 701 XFB A N3  1 
HETATM 4305 N N4  . XFB C 2 .   ? -4.52398  -5.00341  34.90119  1.000 30.37188 ? 701 XFB A N4  1 
HETATM 4306 N N5  . XFB C 2 .   ? -7.53390  -5.15894  32.05259  1.000 39.11549 ? 701 XFB A N5  1 
HETATM 4307 N N6  . XFB C 2 .   ? -7.75899  -6.31257  31.30629  1.000 32.21787 ? 701 XFB A N6  1 
HETATM 4308 N N7  . XFB C 2 .   ? -10.36449 -2.98095  29.50940  1.000 48.83969 ? 701 XFB A N7  1 
HETATM 4309 O O1  . XFB C 2 .   ? -9.23621  -1.06243  32.53709  1.000 33.92225 ? 701 XFB A O1  1 
HETATM 4310 O O2  . XFB C 2 .   ? -11.42152 -2.65298  28.61475  1.000 64.38397 ? 701 XFB A O2  1 
HETATM 4311 O O3  . XFB C 2 .   ? -8.86495  -0.37279  28.10618  1.000 40.28338 ? 701 XFB A O3  1 
HETATM 4312 C C1  . GOL D 3 .   ? -0.03060  3.31270   -1.78244  1.000 36.64217 ? 702 GOL A C1  1 
HETATM 4313 O O1  . GOL D 3 .   ? 0.53476   2.10646   -1.30474  1.000 42.09051 ? 702 GOL A O1  1 
HETATM 4314 C C2  . GOL D 3 .   ? -1.55478  3.26267   -1.71069  1.000 41.46072 ? 702 GOL A C2  1 
HETATM 4315 O O2  . GOL D 3 .   ? -2.08956  2.54312   -2.78807  1.000 53.00821 ? 702 GOL A O2  1 
HETATM 4316 C C3  . GOL D 3 .   ? -1.95070  2.51695   -0.45581  1.000 34.54590 ? 702 GOL A C3  1 
HETATM 4317 O O3  . GOL D 3 .   ? -2.24109  3.43262   0.52501   1.000 36.98811 ? 702 GOL A O3  1 
HETATM 4318 C C1  . XFB E 2 .   ? 6.16897   -1.59668  -8.58492  1.000 33.03168 ? 701 XFB B C1  1 
HETATM 4319 C C10 . XFB E 2 .   ? 9.76423   -1.54080  -11.88605 1.000 27.84249 ? 701 XFB B C10 1 
HETATM 4320 C C11 . XFB E 2 .   ? 9.88087   -1.43277  -13.41165 1.000 36.63537 ? 701 XFB B C11 1 
HETATM 4321 C C12 . XFB E 2 .   ? 10.93448  -0.77285  -12.50637 1.000 35.94455 ? 701 XFB B C12 1 
HETATM 4322 C C13 . XFB E 2 .   ? 6.72052   -3.82530  -8.01245  1.000 38.74058 ? 701 XFB B C13 1 
HETATM 4323 C C14 . XFB E 2 .   ? 4.47153   3.34860   -9.43195  1.000 29.84323 ? 701 XFB B C14 1 
HETATM 4324 C C15 . XFB E 2 .   ? 5.66144   4.52535   -11.04686 1.000 32.07898 ? 701 XFB B C15 1 
HETATM 4325 C C16 . XFB E 2 .   ? 4.87410   5.62075   -10.84872 1.000 28.24391 ? 701 XFB B C16 1 
HETATM 4326 C C17 . XFB E 2 .   ? 3.87597   5.54375   -9.93271  1.000 30.79360 ? 701 XFB B C17 1 
HETATM 4327 C C18 . XFB E 2 .   ? 7.59750   3.64257   -12.40099 1.000 34.16179 ? 701 XFB B C18 1 
HETATM 4328 C C19 . XFB E 2 .   ? 8.39428   4.17336   -13.40266 1.000 40.22084 ? 701 XFB B C19 1 
HETATM 4329 C C2  . XFB E 2 .   ? 5.12499   -1.34258  -7.74776  1.000 34.82886 ? 701 XFB B C2  1 
HETATM 4330 C C20 . XFB E 2 .   ? 7.96405   5.47716   -13.62288 1.000 34.81856 ? 701 XFB B C20 1 
HETATM 4331 C C21 . XFB E 2 .   ? 8.53488   6.48203   -14.63910 1.000 31.50261 ? 701 XFB B C21 1 
HETATM 4332 C C22 . XFB E 2 .   ? 9.58855   3.50690   -14.16429 1.000 40.12916 ? 701 XFB B C22 1 
HETATM 4333 C C23 . XFB E 2 .   ? 9.95971   0.99046   -16.46371 1.000 56.21006 ? 701 XFB B C23 1 
HETATM 4334 C C24 . XFB E 2 .   ? 8.53514   1.00273   -16.21624 1.000 53.29523 ? 701 XFB B C24 1 
HETATM 4335 C C25 . XFB E 2 .   ? 8.25119   1.91262   -15.07775 1.000 47.75787 ? 701 XFB B C25 1 
HETATM 4336 C C3  . XFB E 2 .   ? 4.51826   -0.10179  -7.76540  1.000 26.94872 ? 701 XFB B C3  1 
HETATM 4337 C C4  . XFB E 2 .   ? 4.94557   0.89667   -8.66544  1.000 26.30242 ? 701 XFB B C4  1 
HETATM 4338 C C5  . XFB E 2 .   ? 6.04014   0.64994   -9.54087  1.000 26.86993 ? 701 XFB B C5  1 
HETATM 4339 C C6  . XFB E 2 .   ? 6.66165   -0.61954  -9.50228  1.000 29.13975 ? 701 XFB B C6  1 
HETATM 4340 C C7  . XFB E 2 .   ? 7.84817   -2.58551  -9.66247  1.000 29.94374 ? 701 XFB B C7  1 
HETATM 4341 C C8  . XFB E 2 .   ? 7.76443   -1.30837  -10.18564 1.000 31.57827 ? 701 XFB B C8  1 
HETATM 4342 C C9  . XFB E 2 .   ? 8.63841   -0.68897  -11.28125 1.000 32.12140 ? 701 XFB B C9  1 
HETATM 4343 N N1  . XFB E 2 .   ? 6.94401   -2.60422  -8.80671  1.000 35.25688 ? 701 XFB B N1  1 
HETATM 4344 N N2  . XFB E 2 .   ? 4.21546   2.16952   -8.60531  1.000 28.02934 ? 701 XFB B N2  1 
HETATM 4345 N N3  . XFB E 2 .   ? 5.46964   3.41239   -10.34671 1.000 33.31994 ? 701 XFB B N3  1 
HETATM 4346 N N4  . XFB E 2 .   ? 3.68634   4.42810   -9.23670  1.000 30.32119 ? 701 XFB B N4  1 
HETATM 4347 N N5  . XFB E 2 .   ? 6.71203   4.60120   -12.05127 1.000 33.56363 ? 701 XFB B N5  1 
HETATM 4348 N N6  . XFB E 2 .   ? 6.92930   5.73681   -12.82246 1.000 31.31175 ? 701 XFB B N6  1 
HETATM 4349 N N7  . XFB E 2 .   ? 9.46599   2.32258   -14.61411 1.000 52.71347 ? 701 XFB B N7  1 
HETATM 4350 O O1  . XFB E 2 .   ? 8.44229   0.42885   -11.65142 1.000 33.43177 ? 701 XFB B O1  1 
HETATM 4351 O O2  . XFB E 2 .   ? 10.45262  2.06730   -15.60147 1.000 61.58365 ? 701 XFB B O2  1 
HETATM 4352 O O3  . XFB E 2 .   ? 8.04582   -0.38498  -15.97514 1.000 38.81363 ? 701 XFB B O3  1 
HETATM 4353 O O   . HOH F 4 .   ? -0.72313  -14.83177 10.23992  1.000 38.52575 ? 801 HOH A O   1 
HETATM 4354 O O   . HOH F 4 .   ? 0.26722   -10.17510 34.15697  1.000 32.32251 ? 802 HOH A O   1 
HETATM 4355 O O   . HOH F 4 .   ? -4.86609  6.59412   21.97886  1.000 37.35841 ? 803 HOH A O   1 
HETATM 4356 O O   . HOH F 4 .   ? -12.56526 -1.41913  42.16456  1.000 35.92614 ? 804 HOH A O   1 
HETATM 4357 O O   . HOH F 4 .   ? -11.01329 -6.79877  22.26558  1.000 39.98952 ? 805 HOH A O   1 
HETATM 4358 O O   . HOH F 4 .   ? 1.13684   -8.82922  -3.47246  1.000 54.80150 ? 806 HOH A O   1 
HETATM 4359 O O   . HOH F 4 .   ? 3.59636   14.19937  20.20147  1.000 41.79642 ? 807 HOH A O   1 
HETATM 4360 O O   . HOH F 4 .   ? -8.48138  -10.07658 27.87938  1.000 30.23032 ? 808 HOH A O   1 
HETATM 4361 O O   . HOH F 4 .   ? -7.97994  1.50204   9.00834   1.000 28.96755 ? 809 HOH A O   1 
HETATM 4362 O O   . HOH F 4 .   ? 1.72978   15.51040  17.73939  1.000 42.03667 ? 810 HOH A O   1 
HETATM 4363 O O   . HOH F 4 .   ? 0.98930   -15.63745 12.76172  1.000 41.94223 ? 811 HOH A O   1 
HETATM 4364 O O   . HOH F 4 .   ? 0.29967   -6.27566  40.51633  1.000 30.26373 ? 812 HOH A O   1 
HETATM 4365 O O   . HOH F 4 .   ? 13.91430  -5.94087  11.07271  1.000 39.58310 ? 813 HOH A O   1 
HETATM 4366 O O   . HOH F 4 .   ? -8.62310  -9.21887  21.01143  1.000 32.33208 ? 814 HOH A O   1 
HETATM 4367 O O   . HOH F 4 .   ? 4.601     -17.822   57.649    1.000 36.23516 ? 815 HOH A O   1 
HETATM 4368 O O   . HOH F 4 .   ? -4.12252  -5.06329  2.05638   1.000 40.01046 ? 816 HOH A O   1 
HETATM 4369 O O   . HOH F 4 .   ? -7.53440  -19.58120 10.81137  1.000 36.18804 ? 817 HOH A O   1 
HETATM 4370 O O   . HOH F 4 .   ? -25.09734 -8.15125  30.22148  1.000 35.00263 ? 818 HOH A O   1 
HETATM 4371 O O   . HOH F 4 .   ? -5.04186  -5.85883  15.81194  1.000 27.08994 ? 819 HOH A O   1 
HETATM 4372 O O   . HOH F 4 .   ? -9.53653  -19.15353 18.70318  1.000 38.41213 ? 820 HOH A O   1 
HETATM 4373 O O   . HOH F 4 .   ? -0.48921  -11.82737 15.72566  1.000 29.39134 ? 821 HOH A O   1 
HETATM 4374 O O   . HOH F 4 .   ? -2.04401  6.23307   8.83099   1.000 26.14509 ? 822 HOH A O   1 
HETATM 4375 O O   . HOH F 4 .   ? -0.44300  -8.90226  41.43714  1.000 33.80310 ? 823 HOH A O   1 
HETATM 4376 O O   . HOH F 4 .   ? -11.15665 10.36893  2.84011   1.000 41.44427 ? 824 HOH A O   1 
HETATM 4377 O O   . HOH F 4 .   ? -5.72241  12.12824  14.83205  1.000 36.14422 ? 825 HOH A O   1 
HETATM 4378 O O   . HOH F 4 .   ? 5.86063   0.04613   2.44654   1.000 41.14325 ? 826 HOH A O   1 
HETATM 4379 O O   . HOH F 4 .   ? -0.21429  13.66343  17.06547  1.000 42.92654 ? 827 HOH A O   1 
HETATM 4380 O O   . HOH F 4 .   ? -10.80514 4.54982   33.93673  1.000 42.50267 ? 828 HOH A O   1 
HETATM 4381 O O   . HOH F 4 .   ? -5.64252  2.71478   10.11043  1.000 29.62997 ? 829 HOH A O   1 
HETATM 4382 O O   . HOH F 4 .   ? 8.94062   -12.38667 22.20661  1.000 38.09122 ? 830 HOH A O   1 
HETATM 4383 O O   . HOH F 4 .   ? -2.89881  -16.40230 31.57831  1.000 36.46096 ? 831 HOH A O   1 
HETATM 4384 O O   . HOH F 4 .   ? 2.52242   3.99403   5.02662   1.000 25.10166 ? 832 HOH A O   1 
HETATM 4385 O O   . HOH F 4 .   ? -6.55232  2.94359   22.06204  1.000 28.29589 ? 833 HOH A O   1 
HETATM 4386 O O   . HOH F 4 .   ? 1.06626   -17.93492 47.44266  1.000 49.77921 ? 834 HOH A O   1 
HETATM 4387 O O   . HOH F 4 .   ? 8.67469   -9.82073  7.92556   1.000 39.26767 ? 835 HOH A O   1 
HETATM 4388 O O   . HOH F 4 .   ? 8.12006   8.09305   6.82418   1.000 31.93723 ? 836 HOH A O   1 
HETATM 4389 O O   . HOH F 4 .   ? -17.71421 -18.80241 43.48773  1.000 44.84688 ? 837 HOH A O   1 
HETATM 4390 O O   . HOH F 4 .   ? 1.24138   -14.67092 29.90857  1.000 32.21686 ? 838 HOH A O   1 
HETATM 4391 O O   . HOH F 4 .   ? -16.10778 -8.36926  47.25559  1.000 36.32810 ? 839 HOH A O   1 
HETATM 4392 O O   . HOH F 4 .   ? -3.64017  5.20038   -4.37300  1.000 31.79444 ? 840 HOH A O   1 
HETATM 4393 O O   . HOH F 4 .   ? -12.36252 2.89948   14.83224  1.000 34.22007 ? 841 HOH A O   1 
HETATM 4394 O O   . HOH F 4 .   ? -0.58178  -7.80091  34.59601  1.000 30.55954 ? 842 HOH A O   1 
HETATM 4395 O O   . HOH F 4 .   ? 1.87814   -3.40423  38.57137  1.000 34.00291 ? 843 HOH A O   1 
HETATM 4396 O O   . HOH F 4 .   ? -11.12110 -7.97176  25.28542  1.000 41.13614 ? 844 HOH A O   1 
HETATM 4397 O O   . HOH F 4 .   ? 0.867     -25.932   10.457    1.000 36.23396 ? 845 HOH A O   1 
HETATM 4398 O O   . HOH F 4 .   ? 8.95121   -10.66716 10.20390  1.000 34.65388 ? 846 HOH A O   1 
HETATM 4399 O O   . HOH F 4 .   ? -17.54304 -25.27629 33.15923  1.000 53.26348 ? 847 HOH A O   1 
HETATM 4400 O O   . HOH F 4 .   ? 3.44437   -12.63984 9.84274   1.000 41.08372 ? 848 HOH A O   1 
HETATM 4401 O O   . HOH F 4 .   ? 0.98353   -12.84800 8.94272   1.000 34.00085 ? 849 HOH A O   1 
HETATM 4402 O O   . HOH F 4 .   ? -8.40514  -14.23550 52.06035  1.000 45.10404 ? 850 HOH A O   1 
HETATM 4403 O O   . HOH F 4 .   ? -18.87694 -11.32479 11.06406  1.000 48.94822 ? 851 HOH A O   1 
HETATM 4404 O O   . HOH F 4 .   ? -14.68167 -6.30567  14.51708  1.000 56.30468 ? 852 HOH A O   1 
HETATM 4405 O O   . HOH F 4 .   ? -1.27535  -16.27084 36.79517  1.000 43.39540 ? 853 HOH A O   1 
HETATM 4406 O O   . HOH F 4 .   ? 24.54950  6.58562   22.08401  1.000 49.37190 ? 854 HOH A O   1 
HETATM 4407 O O   . HOH F 4 .   ? -18.51643 -5.64301  10.77615  1.000 55.77574 ? 855 HOH A O   1 
HETATM 4408 O O   . HOH F 4 .   ? -0.30893  -7.80639  -6.45901  1.000 45.80604 ? 856 HOH A O   1 
HETATM 4409 O O   . HOH G 4 .   ? 1.94490   -1.78737  -0.47432  1.000 39.75693 ? 801 HOH B O   1 
HETATM 4410 O O   . HOH G 4 .   ? 14.33584  0.15573   -18.82621 1.000 46.74264 ? 802 HOH B O   1 
HETATM 4411 O O   . HOH G 4 .   ? -0.06945  14.21742  -33.93986 1.000 37.27061 ? 803 HOH B O   1 
HETATM 4412 O O   . HOH G 4 .   ? -4.31372  11.96017  -2.24081  1.000 42.41915 ? 804 HOH B O   1 
HETATM 4413 O O   . HOH G 4 .   ? -13.67767 -3.93936  -33.08223 1.000 42.90476 ? 805 HOH B O   1 
HETATM 4414 O O   . HOH G 4 .   ? 2.39147   3.70233   2.35514   1.000 31.67331 ? 806 HOH B O   1 
HETATM 4415 O O   . HOH G 4 .   ? 7.20219   -2.13780  -35.17605 1.000 29.50951 ? 807 HOH B O   1 
HETATM 4416 O O   . HOH G 4 .   ? -0.32717  11.28719  -28.54194 1.000 28.30294 ? 808 HOH B O   1 
HETATM 4417 O O   . HOH G 4 .   ? 7.52678   9.47556   -16.24588 1.000 30.94079 ? 809 HOH B O   1 
HETATM 4418 O O   . HOH G 4 .   ? 4.66026   4.07741   -32.80322 1.000 31.48389 ? 810 HOH B O   1 
HETATM 4419 O O   . HOH G 4 .   ? 1.53243   1.26625   1.15746   1.000 31.93514 ? 811 HOH B O   1 
HETATM 4420 O O   . HOH G 4 .   ? -1.24801  9.67659   -10.10524 1.000 27.82164 ? 812 HOH B O   1 
HETATM 4421 O O   . HOH G 4 .   ? 5.72054   -3.64692  -22.11920 1.000 30.89942 ? 813 HOH B O   1 
HETATM 4422 O O   . HOH G 4 .   ? 10.31400  6.29659   -21.89616 1.000 37.58158 ? 814 HOH B O   1 
HETATM 4423 O O   . HOH G 4 .   ? -6.667    -0.629    -41.593   1.000 35.34645 ? 815 HOH B O   1 
HETATM 4424 O O   . HOH G 4 .   ? 4.03739   -7.32865  -22.04876 1.000 38.31137 ? 816 HOH B O   1 
HETATM 4425 O O   . HOH G 4 .   ? 2.68348   -5.16818  -11.46458 1.000 34.73974 ? 817 HOH B O   1 
HETATM 4426 O O   . HOH G 4 .   ? -3.28830  -4.63955  -39.18514 1.000 23.17933 ? 818 HOH B O   1 
HETATM 4427 O O   . HOH G 4 .   ? 8.83348   18.51255  -25.52707 1.000 43.20206 ? 819 HOH B O   1 
HETATM 4428 O O   . HOH G 4 .   ? 7.92959   8.61562   -23.06007 1.000 29.22663 ? 820 HOH B O   1 
HETATM 4429 O O   . HOH G 4 .   ? 10.29661  -10.97316 -41.24201 1.000 36.24333 ? 821 HOH B O   1 
HETATM 4430 O O   . HOH G 4 .   ? -2.49077  2.94627   -5.62118  1.000 34.02347 ? 822 HOH B O   1 
HETATM 4431 O O   . HOH G 4 .   ? -0.21937  8.20652   -2.74115  1.000 35.07610 ? 823 HOH B O   1 
HETATM 4432 O O   . HOH G 4 .   ? -4.72364  -0.17637  -4.45313  1.000 37.84152 ? 824 HOH B O   1 
HETATM 4433 O O   . HOH G 4 .   ? 0.67874   14.14086  -14.49785 1.000 37.77124 ? 825 HOH B O   1 
HETATM 4434 O O   . HOH G 4 .   ? 4.21852   5.22469   -28.41340 1.000 28.62678 ? 826 HOH B O   1 
HETATM 4435 O O   . HOH G 4 .   ? 9.16140   18.77819  -29.77003 1.000 49.20927 ? 827 HOH B O   1 
HETATM 4436 O O   . HOH G 4 .   ? 2.82287   -5.69413  -48.36660 1.000 32.39077 ? 828 HOH B O   1 
HETATM 4437 O O   . HOH G 4 .   ? -1.64267  15.22044  -31.44843 1.000 38.84090 ? 829 HOH B O   1 
HETATM 4438 O O   . HOH G 4 .   ? 4.90965   -3.16758  -34.10355 1.000 26.41685 ? 830 HOH B O   1 
HETATM 4439 O O   . HOH G 4 .   ? 4.88953   -12.79822 -29.47775 1.000 35.53356 ? 831 HOH B O   1 
HETATM 4440 O O   . HOH G 4 .   ? 26.641    5.524     -14.912   1.000 33.23323 ? 832 HOH B O   1 
HETATM 4441 O O   . HOH G 4 .   ? 2.13024   15.81619  -12.57252 1.000 38.68172 ? 833 HOH B O   1 
HETATM 4442 O O   . HOH G 4 .   ? -2.11554  13.81401  -14.21343 1.000 33.31076 ? 834 HOH B O   1 
HETATM 4443 O O   . HOH G 4 .   ? 10.16780  -5.28214  -10.17331 1.000 39.79210 ? 835 HOH B O   1 
HETATM 4444 O O   . HOH G 4 .   ? -2.09378  6.45044   -7.85088  1.000 34.44228 ? 836 HOH B O   1 
HETATM 4445 O O   . HOH G 4 .   ? -0.15053  7.22565   -9.54469  1.000 32.27698 ? 837 HOH B O   1 
HETATM 4446 O O   . HOH G 4 .   ? 6.73496   18.88062  -33.54666 1.000 37.90518 ? 838 HOH B O   1 
HETATM 4447 O O   . HOH G 4 .   ? 9.74308   -2.46969  -1.10146  1.000 45.23955 ? 839 HOH B O   1 
HETATM 4448 O O   . HOH G 4 .   ? 11.51916  -3.40918  -29.34852 1.000 32.14727 ? 840 HOH B O   1 
HETATM 4449 O O   . HOH G 4 .   ? 1.18533   -6.84256  -35.34001 1.000 27.22622 ? 841 HOH B O   1 
HETATM 4450 O O   . HOH G 4 .   ? 7.52140   13.68018  8.06056   1.000 47.96895 ? 842 HOH B O   1 
HETATM 4451 O O   . HOH G 4 .   ? 0.45376   15.87827  -6.95211  1.000 44.78104 ? 843 HOH B O   1 
HETATM 4452 O O   . HOH G 4 .   ? 16.66492  -6.40946  -32.38565 1.000 49.26825 ? 844 HOH B O   1 
HETATM 4453 O O   . HOH G 4 .   ? 15.35015  7.90961   3.32441   1.000 39.68732 ? 845 HOH B O   1 
HETATM 4454 O O   . HOH G 4 .   ? -3.85379  12.36379  -11.44196 1.000 42.65167 ? 846 HOH B O   1 
HETATM 4455 O O   . HOH G 4 .   ? -9.71497  10.21951  -33.84552 1.000 34.80070 ? 847 HOH B O   1 
HETATM 4456 O O   . HOH G 4 .   ? -1.64639  12.28027  -35.33974 1.000 34.23497 ? 848 HOH B O   1 
HETATM 4457 O O   . HOH G 4 .   ? -9.32966  -15.91910 -16.77775 1.000 51.59001 ? 849 HOH B O   1 
HETATM 4458 O O   . HOH G 4 .   ? 8.83919   -0.57554  -23.29498 1.000 44.30203 ? 850 HOH B O   1 
HETATM 4459 O O   . HOH G 4 .   ? 8.11977   -5.14473  -21.66851 1.000 38.74834 ? 851 HOH B O   1 
# 
