data_8WYV
# 
_entry.id   8WYV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8WYV         pdb_00008wyv 10.2210/pdb8wyv/pdb 
WWPDB D_1300042287 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8WYV 
_pdbx_database_status.recvd_initial_deposition_date   2023-10-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 8WXC unspecified 
PDB . 8WY2 unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              aquarius@g.ecc.u-tokyo.ac.jp 
_pdbx_contact_author.name_first         Kiyohiko 
_pdbx_contact_author.name_last          Igarashi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5152-7177 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yamaguchi, S.' 1 ? 
'Sunagawa, N.'  2 ? 
'Tachioka, M.'  3 ? 
'Igarashi, K.'  4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Activity and X-ray crystal structure of candidate base catalyst mutants of glycoside hydrolase family 6 cellobiohydrolase' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yamaguchi, S.' 1 ? 
primary 'Sunagawa, N.'  2 ? 
primary 'Tachioka, M.'  3 ? 
primary 'Igarashi, K.'  4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Glucanase 38360.516 1   ? D170N,S176V,C240S,C393S ? ? 
2 water   nat water     18.015    461 ? ?                       ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRNCAAKAVNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLASV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGESDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRNCAAKAVNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLASV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGESDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   ALA n 
1 3   ASN n 
1 4   ASN n 
1 5   PRO n 
1 6   TRP n 
1 7   THR n 
1 8   GLY n 
1 9   PHE n 
1 10  GLN n 
1 11  ILE n 
1 12  PHE n 
1 13  LEU n 
1 14  SER n 
1 15  PRO n 
1 16  TYR n 
1 17  TYR n 
1 18  ALA n 
1 19  ASN n 
1 20  GLU n 
1 21  VAL n 
1 22  ALA n 
1 23  ALA n 
1 24  ALA n 
1 25  ALA n 
1 26  LYS n 
1 27  GLN n 
1 28  ILE n 
1 29  THR n 
1 30  ASP n 
1 31  PRO n 
1 32  THR n 
1 33  LEU n 
1 34  SER n 
1 35  SER n 
1 36  LYS n 
1 37  ALA n 
1 38  ALA n 
1 39  SER n 
1 40  VAL n 
1 41  ALA n 
1 42  ASN n 
1 43  ILE n 
1 44  PRO n 
1 45  THR n 
1 46  PHE n 
1 47  THR n 
1 48  TRP n 
1 49  LEU n 
1 50  ASP n 
1 51  SER n 
1 52  VAL n 
1 53  ALA n 
1 54  LYS n 
1 55  ILE n 
1 56  PRO n 
1 57  ASP n 
1 58  LEU n 
1 59  GLY n 
1 60  THR n 
1 61  TYR n 
1 62  LEU n 
1 63  ALA n 
1 64  SER n 
1 65  ALA n 
1 66  SER n 
1 67  ALA n 
1 68  LEU n 
1 69  GLY n 
1 70  LYS n 
1 71  SER n 
1 72  THR n 
1 73  GLY n 
1 74  THR n 
1 75  LYS n 
1 76  GLN n 
1 77  LEU n 
1 78  VAL n 
1 79  GLN n 
1 80  ILE n 
1 81  VAL n 
1 82  ILE n 
1 83  TYR n 
1 84  ASP n 
1 85  LEU n 
1 86  PRO n 
1 87  ASP n 
1 88  ARG n 
1 89  ASN n 
1 90  CYS n 
1 91  ALA n 
1 92  ALA n 
1 93  LYS n 
1 94  ALA n 
1 95  VAL n 
1 96  ASN n 
1 97  GLY n 
1 98  GLU n 
1 99  PHE n 
1 100 SER n 
1 101 ILE n 
1 102 ALA n 
1 103 ASN n 
1 104 ASN n 
1 105 GLY n 
1 106 GLN n 
1 107 ALA n 
1 108 ASN n 
1 109 TYR n 
1 110 GLU n 
1 111 ASN n 
1 112 TYR n 
1 113 ILE n 
1 114 ASP n 
1 115 GLN n 
1 116 ILE n 
1 117 VAL n 
1 118 ALA n 
1 119 GLN n 
1 120 ILE n 
1 121 GLN n 
1 122 GLN n 
1 123 PHE n 
1 124 PRO n 
1 125 ASP n 
1 126 VAL n 
1 127 ARG n 
1 128 VAL n 
1 129 VAL n 
1 130 ALA n 
1 131 VAL n 
1 132 ILE n 
1 133 GLU n 
1 134 PRO n 
1 135 ASP n 
1 136 SER n 
1 137 LEU n 
1 138 ALA n 
1 139 ASN n 
1 140 LEU n 
1 141 VAL n 
1 142 THR n 
1 143 ASN n 
1 144 LEU n 
1 145 ASN n 
1 146 VAL n 
1 147 GLN n 
1 148 LYS n 
1 149 CYS n 
1 150 ALA n 
1 151 ASN n 
1 152 ALA n 
1 153 LYS n 
1 154 THR n 
1 155 THR n 
1 156 TYR n 
1 157 LEU n 
1 158 ALA n 
1 159 SER n 
1 160 VAL n 
1 161 ASN n 
1 162 TYR n 
1 163 ALA n 
1 164 LEU n 
1 165 THR n 
1 166 ASN n 
1 167 LEU n 
1 168 ALA n 
1 169 LYS n 
1 170 VAL n 
1 171 GLY n 
1 172 VAL n 
1 173 TYR n 
1 174 MET n 
1 175 TYR n 
1 176 MET n 
1 177 ASP n 
1 178 ALA n 
1 179 GLY n 
1 180 HIS n 
1 181 ALA n 
1 182 GLY n 
1 183 TRP n 
1 184 LEU n 
1 185 GLY n 
1 186 TRP n 
1 187 PRO n 
1 188 ALA n 
1 189 ASN n 
1 190 LEU n 
1 191 SER n 
1 192 PRO n 
1 193 ALA n 
1 194 ALA n 
1 195 GLN n 
1 196 LEU n 
1 197 PHE n 
1 198 THR n 
1 199 GLN n 
1 200 VAL n 
1 201 TRP n 
1 202 GLN n 
1 203 ASN n 
1 204 ALA n 
1 205 GLY n 
1 206 LYS n 
1 207 SER n 
1 208 PRO n 
1 209 PHE n 
1 210 ILE n 
1 211 LYS n 
1 212 GLY n 
1 213 LEU n 
1 214 ALA n 
1 215 THR n 
1 216 ASN n 
1 217 VAL n 
1 218 ALA n 
1 219 ASN n 
1 220 TYR n 
1 221 ASN n 
1 222 ALA n 
1 223 LEU n 
1 224 GLN n 
1 225 ALA n 
1 226 ALA n 
1 227 SER n 
1 228 PRO n 
1 229 ASP n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 GLN n 
1 234 GLY n 
1 235 ASN n 
1 236 PRO n 
1 237 ASN n 
1 238 TYR n 
1 239 ASP n 
1 240 GLU n 
1 241 ILE n 
1 242 HIS n 
1 243 TYR n 
1 244 ILE n 
1 245 ASN n 
1 246 ALA n 
1 247 LEU n 
1 248 ALA n 
1 249 PRO n 
1 250 LEU n 
1 251 LEU n 
1 252 GLN n 
1 253 GLN n 
1 254 ALA n 
1 255 GLY n 
1 256 TRP n 
1 257 ASP n 
1 258 ALA n 
1 259 THR n 
1 260 PHE n 
1 261 ILE n 
1 262 VAL n 
1 263 ASP n 
1 264 GLN n 
1 265 GLY n 
1 266 ARG n 
1 267 SER n 
1 268 GLY n 
1 269 VAL n 
1 270 GLN n 
1 271 ASN n 
1 272 ILE n 
1 273 ARG n 
1 274 GLN n 
1 275 GLN n 
1 276 TRP n 
1 277 GLY n 
1 278 ASP n 
1 279 TRP n 
1 280 CYS n 
1 281 ASN n 
1 282 ILE n 
1 283 LYS n 
1 284 GLY n 
1 285 ALA n 
1 286 GLY n 
1 287 PHE n 
1 288 GLY n 
1 289 THR n 
1 290 ARG n 
1 291 PRO n 
1 292 THR n 
1 293 THR n 
1 294 ASN n 
1 295 THR n 
1 296 GLY n 
1 297 SER n 
1 298 GLN n 
1 299 PHE n 
1 300 ILE n 
1 301 ASP n 
1 302 SER n 
1 303 ILE n 
1 304 VAL n 
1 305 TRP n 
1 306 VAL n 
1 307 LYS n 
1 308 PRO n 
1 309 GLY n 
1 310 GLY n 
1 311 GLU n 
1 312 SER n 
1 313 ASP n 
1 314 GLY n 
1 315 THR n 
1 316 SER n 
1 317 ASN n 
1 318 SER n 
1 319 SER n 
1 320 SER n 
1 321 PRO n 
1 322 ARG n 
1 323 TYR n 
1 324 ASP n 
1 325 SER n 
1 326 THR n 
1 327 CYS n 
1 328 SER n 
1 329 LEU n 
1 330 PRO n 
1 331 ASP n 
1 332 ALA n 
1 333 ALA n 
1 334 GLN n 
1 335 PRO n 
1 336 ALA n 
1 337 PRO n 
1 338 GLU n 
1 339 ALA n 
1 340 GLY n 
1 341 THR n 
1 342 TRP n 
1 343 PHE n 
1 344 GLN n 
1 345 ALA n 
1 346 TYR n 
1 347 PHE n 
1 348 GLN n 
1 349 THR n 
1 350 LEU n 
1 351 VAL n 
1 352 SER n 
1 353 ALA n 
1 354 ALA n 
1 355 ASN n 
1 356 PRO n 
1 357 PRO n 
1 358 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   358 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 cel6A 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    K-3 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Phanerodontia chrysosporium' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2822231 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Komagataella pastoris' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     4922 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               KM71H 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pPICZalpha 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   82  82  SER SER A . n 
A 1 2   ALA 2   83  83  ALA ALA A . n 
A 1 3   ASN 3   84  84  ASN ASN A . n 
A 1 4   ASN 4   85  85  ASN ASN A . n 
A 1 5   PRO 5   86  86  PRO PRO A . n 
A 1 6   TRP 6   87  87  TRP TRP A . n 
A 1 7   THR 7   88  88  THR THR A . n 
A 1 8   GLY 8   89  89  GLY GLY A . n 
A 1 9   PHE 9   90  90  PHE PHE A . n 
A 1 10  GLN 10  91  91  GLN GLN A . n 
A 1 11  ILE 11  92  92  ILE ILE A . n 
A 1 12  PHE 12  93  93  PHE PHE A . n 
A 1 13  LEU 13  94  94  LEU LEU A . n 
A 1 14  SER 14  95  95  SER SER A . n 
A 1 15  PRO 15  96  96  PRO PRO A . n 
A 1 16  TYR 16  97  97  TYR TYR A . n 
A 1 17  TYR 17  98  98  TYR TYR A . n 
A 1 18  ALA 18  99  99  ALA ALA A . n 
A 1 19  ASN 19  100 100 ASN ASN A . n 
A 1 20  GLU 20  101 101 GLU GLU A . n 
A 1 21  VAL 21  102 102 VAL VAL A . n 
A 1 22  ALA 22  103 103 ALA ALA A . n 
A 1 23  ALA 23  104 104 ALA ALA A . n 
A 1 24  ALA 24  105 105 ALA ALA A . n 
A 1 25  ALA 25  106 106 ALA ALA A . n 
A 1 26  LYS 26  107 107 LYS LYS A . n 
A 1 27  GLN 27  108 108 GLN GLN A . n 
A 1 28  ILE 28  109 109 ILE ILE A . n 
A 1 29  THR 29  110 110 THR THR A . n 
A 1 30  ASP 30  111 111 ASP ASP A . n 
A 1 31  PRO 31  112 112 PRO PRO A . n 
A 1 32  THR 32  113 113 THR THR A . n 
A 1 33  LEU 33  114 114 LEU LEU A . n 
A 1 34  SER 34  115 115 SER SER A . n 
A 1 35  SER 35  116 116 SER SER A . n 
A 1 36  LYS 36  117 117 LYS LYS A . n 
A 1 37  ALA 37  118 118 ALA ALA A . n 
A 1 38  ALA 38  119 119 ALA ALA A . n 
A 1 39  SER 39  120 120 SER SER A . n 
A 1 40  VAL 40  121 121 VAL VAL A . n 
A 1 41  ALA 41  122 122 ALA ALA A . n 
A 1 42  ASN 42  123 123 ASN ASN A . n 
A 1 43  ILE 43  124 124 ILE ILE A . n 
A 1 44  PRO 44  125 125 PRO PRO A . n 
A 1 45  THR 45  126 126 THR THR A . n 
A 1 46  PHE 46  127 127 PHE PHE A . n 
A 1 47  THR 47  128 128 THR THR A . n 
A 1 48  TRP 48  129 129 TRP TRP A . n 
A 1 49  LEU 49  130 130 LEU LEU A . n 
A 1 50  ASP 50  131 131 ASP ASP A . n 
A 1 51  SER 51  132 132 SER SER A . n 
A 1 52  VAL 52  133 133 VAL VAL A . n 
A 1 53  ALA 53  134 134 ALA ALA A . n 
A 1 54  LYS 54  135 135 LYS LYS A . n 
A 1 55  ILE 55  136 136 ILE ILE A . n 
A 1 56  PRO 56  137 137 PRO PRO A . n 
A 1 57  ASP 57  138 138 ASP ASP A . n 
A 1 58  LEU 58  139 139 LEU LEU A . n 
A 1 59  GLY 59  140 140 GLY GLY A . n 
A 1 60  THR 60  141 141 THR THR A . n 
A 1 61  TYR 61  142 142 TYR TYR A . n 
A 1 62  LEU 62  143 143 LEU LEU A . n 
A 1 63  ALA 63  144 144 ALA ALA A . n 
A 1 64  SER 64  145 145 SER SER A . n 
A 1 65  ALA 65  146 146 ALA ALA A . n 
A 1 66  SER 66  147 147 SER SER A . n 
A 1 67  ALA 67  148 148 ALA ALA A . n 
A 1 68  LEU 68  149 149 LEU LEU A . n 
A 1 69  GLY 69  150 150 GLY GLY A . n 
A 1 70  LYS 70  151 151 LYS LYS A . n 
A 1 71  SER 71  152 152 SER SER A . n 
A 1 72  THR 72  153 153 THR THR A . n 
A 1 73  GLY 73  154 154 GLY GLY A . n 
A 1 74  THR 74  155 155 THR THR A . n 
A 1 75  LYS 75  156 156 LYS LYS A . n 
A 1 76  GLN 76  157 157 GLN GLN A . n 
A 1 77  LEU 77  158 158 LEU LEU A . n 
A 1 78  VAL 78  159 159 VAL VAL A . n 
A 1 79  GLN 79  160 160 GLN GLN A . n 
A 1 80  ILE 80  161 161 ILE ILE A . n 
A 1 81  VAL 81  162 162 VAL VAL A . n 
A 1 82  ILE 82  163 163 ILE ILE A . n 
A 1 83  TYR 83  164 164 TYR TYR A . n 
A 1 84  ASP 84  165 165 ASP ASP A . n 
A 1 85  LEU 85  166 166 LEU LEU A . n 
A 1 86  PRO 86  167 167 PRO PRO A . n 
A 1 87  ASP 87  168 168 ASP ASP A . n 
A 1 88  ARG 88  169 169 ARG ARG A . n 
A 1 89  ASN 89  170 170 ASN ASN A . n 
A 1 90  CYS 90  171 171 CYS CYS A . n 
A 1 91  ALA 91  172 172 ALA ALA A . n 
A 1 92  ALA 92  173 173 ALA ALA A . n 
A 1 93  LYS 93  174 174 LYS LYS A . n 
A 1 94  ALA 94  175 175 ALA ALA A . n 
A 1 95  VAL 95  176 176 VAL VAL A . n 
A 1 96  ASN 96  177 177 ASN ASN A . n 
A 1 97  GLY 97  178 178 GLY GLY A . n 
A 1 98  GLU 98  179 179 GLU GLU A . n 
A 1 99  PHE 99  180 180 PHE PHE A . n 
A 1 100 SER 100 181 181 SER SER A . n 
A 1 101 ILE 101 182 182 ILE ILE A . n 
A 1 102 ALA 102 183 183 ALA ALA A . n 
A 1 103 ASN 103 184 184 ASN ASN A . n 
A 1 104 ASN 104 185 185 ASN ASN A . n 
A 1 105 GLY 105 186 186 GLY GLY A . n 
A 1 106 GLN 106 187 187 GLN GLN A . n 
A 1 107 ALA 107 188 188 ALA ALA A . n 
A 1 108 ASN 108 189 189 ASN ASN A . n 
A 1 109 TYR 109 190 190 TYR TYR A . n 
A 1 110 GLU 110 191 191 GLU GLU A . n 
A 1 111 ASN 111 192 192 ASN ASN A . n 
A 1 112 TYR 112 193 193 TYR TYR A . n 
A 1 113 ILE 113 194 194 ILE ILE A . n 
A 1 114 ASP 114 195 195 ASP ASP A . n 
A 1 115 GLN 115 196 196 GLN GLN A . n 
A 1 116 ILE 116 197 197 ILE ILE A . n 
A 1 117 VAL 117 198 198 VAL VAL A . n 
A 1 118 ALA 118 199 199 ALA ALA A . n 
A 1 119 GLN 119 200 200 GLN GLN A . n 
A 1 120 ILE 120 201 201 ILE ILE A . n 
A 1 121 GLN 121 202 202 GLN GLN A . n 
A 1 122 GLN 122 203 203 GLN GLN A . n 
A 1 123 PHE 123 204 204 PHE PHE A . n 
A 1 124 PRO 124 205 205 PRO PRO A . n 
A 1 125 ASP 125 206 206 ASP ASP A . n 
A 1 126 VAL 126 207 207 VAL VAL A . n 
A 1 127 ARG 127 208 208 ARG ARG A . n 
A 1 128 VAL 128 209 209 VAL VAL A . n 
A 1 129 VAL 129 210 210 VAL VAL A . n 
A 1 130 ALA 130 211 211 ALA ALA A . n 
A 1 131 VAL 131 212 212 VAL VAL A . n 
A 1 132 ILE 132 213 213 ILE ILE A . n 
A 1 133 GLU 133 214 214 GLU GLU A . n 
A 1 134 PRO 134 215 215 PRO PRO A . n 
A 1 135 ASP 135 216 216 ASP ASP A . n 
A 1 136 SER 136 217 217 SER SER A . n 
A 1 137 LEU 137 218 218 LEU LEU A . n 
A 1 138 ALA 138 219 219 ALA ALA A . n 
A 1 139 ASN 139 220 220 ASN ASN A . n 
A 1 140 LEU 140 221 221 LEU LEU A . n 
A 1 141 VAL 141 222 222 VAL VAL A . n 
A 1 142 THR 142 223 223 THR THR A . n 
A 1 143 ASN 143 224 224 ASN ASN A . n 
A 1 144 LEU 144 225 225 LEU LEU A . n 
A 1 145 ASN 145 226 226 ASN ASN A . n 
A 1 146 VAL 146 227 227 VAL VAL A . n 
A 1 147 GLN 147 228 228 GLN GLN A . n 
A 1 148 LYS 148 229 229 LYS LYS A . n 
A 1 149 CYS 149 230 230 CYS CYS A . n 
A 1 150 ALA 150 231 231 ALA ALA A . n 
A 1 151 ASN 151 232 232 ASN ASN A . n 
A 1 152 ALA 152 233 233 ALA ALA A . n 
A 1 153 LYS 153 234 234 LYS LYS A . n 
A 1 154 THR 154 235 235 THR THR A . n 
A 1 155 THR 155 236 236 THR THR A . n 
A 1 156 TYR 156 237 237 TYR TYR A . n 
A 1 157 LEU 157 238 238 LEU LEU A . n 
A 1 158 ALA 158 239 239 ALA ALA A . n 
A 1 159 SER 159 240 240 SER SER A . n 
A 1 160 VAL 160 241 241 VAL VAL A . n 
A 1 161 ASN 161 242 242 ASN ASN A . n 
A 1 162 TYR 162 243 243 TYR TYR A . n 
A 1 163 ALA 163 244 244 ALA ALA A . n 
A 1 164 LEU 164 245 245 LEU LEU A . n 
A 1 165 THR 165 246 246 THR THR A . n 
A 1 166 ASN 166 247 247 ASN ASN A . n 
A 1 167 LEU 167 248 248 LEU LEU A . n 
A 1 168 ALA 168 249 249 ALA ALA A . n 
A 1 169 LYS 169 250 250 LYS LYS A . n 
A 1 170 VAL 170 251 251 VAL VAL A . n 
A 1 171 GLY 171 252 252 GLY GLY A . n 
A 1 172 VAL 172 253 253 VAL VAL A . n 
A 1 173 TYR 173 254 254 TYR TYR A . n 
A 1 174 MET 174 255 255 MET MET A . n 
A 1 175 TYR 175 256 256 TYR TYR A . n 
A 1 176 MET 176 257 257 MET MET A . n 
A 1 177 ASP 177 258 258 ASP ASP A . n 
A 1 178 ALA 178 259 259 ALA ALA A . n 
A 1 179 GLY 179 260 260 GLY GLY A . n 
A 1 180 HIS 180 261 261 HIS HIS A . n 
A 1 181 ALA 181 262 262 ALA ALA A . n 
A 1 182 GLY 182 263 263 GLY GLY A . n 
A 1 183 TRP 183 264 264 TRP TRP A . n 
A 1 184 LEU 184 265 265 LEU LEU A . n 
A 1 185 GLY 185 266 266 GLY GLY A . n 
A 1 186 TRP 186 267 267 TRP TRP A . n 
A 1 187 PRO 187 268 268 PRO PRO A . n 
A 1 188 ALA 188 269 269 ALA ALA A . n 
A 1 189 ASN 189 270 270 ASN ASN A . n 
A 1 190 LEU 190 271 271 LEU LEU A . n 
A 1 191 SER 191 272 272 SER SER A . n 
A 1 192 PRO 192 273 273 PRO PRO A . n 
A 1 193 ALA 193 274 274 ALA ALA A . n 
A 1 194 ALA 194 275 275 ALA ALA A . n 
A 1 195 GLN 195 276 276 GLN GLN A . n 
A 1 196 LEU 196 277 277 LEU LEU A . n 
A 1 197 PHE 197 278 278 PHE PHE A . n 
A 1 198 THR 198 279 279 THR THR A . n 
A 1 199 GLN 199 280 280 GLN GLN A . n 
A 1 200 VAL 200 281 281 VAL VAL A . n 
A 1 201 TRP 201 282 282 TRP TRP A . n 
A 1 202 GLN 202 283 283 GLN GLN A . n 
A 1 203 ASN 203 284 284 ASN ASN A . n 
A 1 204 ALA 204 285 285 ALA ALA A . n 
A 1 205 GLY 205 286 286 GLY GLY A . n 
A 1 206 LYS 206 287 287 LYS LYS A . n 
A 1 207 SER 207 288 288 SER SER A . n 
A 1 208 PRO 208 289 289 PRO PRO A . n 
A 1 209 PHE 209 290 290 PHE PHE A . n 
A 1 210 ILE 210 291 291 ILE ILE A . n 
A 1 211 LYS 211 292 292 LYS LYS A . n 
A 1 212 GLY 212 293 293 GLY GLY A . n 
A 1 213 LEU 213 294 294 LEU LEU A . n 
A 1 214 ALA 214 295 295 ALA ALA A . n 
A 1 215 THR 215 296 296 THR THR A . n 
A 1 216 ASN 216 297 297 ASN ASN A . n 
A 1 217 VAL 217 298 298 VAL VAL A . n 
A 1 218 ALA 218 299 299 ALA ALA A . n 
A 1 219 ASN 219 300 300 ASN ASN A . n 
A 1 220 TYR 220 301 301 TYR TYR A . n 
A 1 221 ASN 221 302 302 ASN ASN A . n 
A 1 222 ALA 222 303 303 ALA ALA A . n 
A 1 223 LEU 223 304 304 LEU LEU A . n 
A 1 224 GLN 224 305 305 GLN GLN A . n 
A 1 225 ALA 225 306 306 ALA ALA A . n 
A 1 226 ALA 226 307 307 ALA ALA A . n 
A 1 227 SER 227 308 308 SER SER A . n 
A 1 228 PRO 228 309 309 PRO PRO A . n 
A 1 229 ASP 229 310 310 ASP ASP A . n 
A 1 230 PRO 230 311 311 PRO PRO A . n 
A 1 231 ILE 231 312 312 ILE ILE A . n 
A 1 232 THR 232 313 313 THR THR A . n 
A 1 233 GLN 233 314 314 GLN GLN A . n 
A 1 234 GLY 234 315 315 GLY GLY A . n 
A 1 235 ASN 235 316 316 ASN ASN A . n 
A 1 236 PRO 236 317 317 PRO PRO A . n 
A 1 237 ASN 237 318 318 ASN ASN A . n 
A 1 238 TYR 238 319 319 TYR TYR A . n 
A 1 239 ASP 239 320 320 ASP ASP A . n 
A 1 240 GLU 240 321 321 GLU GLU A . n 
A 1 241 ILE 241 322 322 ILE ILE A . n 
A 1 242 HIS 242 323 323 HIS HIS A . n 
A 1 243 TYR 243 324 324 TYR TYR A . n 
A 1 244 ILE 244 325 325 ILE ILE A . n 
A 1 245 ASN 245 326 326 ASN ASN A . n 
A 1 246 ALA 246 327 327 ALA ALA A . n 
A 1 247 LEU 247 328 328 LEU LEU A . n 
A 1 248 ALA 248 329 329 ALA ALA A . n 
A 1 249 PRO 249 330 330 PRO PRO A . n 
A 1 250 LEU 250 331 331 LEU LEU A . n 
A 1 251 LEU 251 332 332 LEU LEU A . n 
A 1 252 GLN 252 333 333 GLN GLN A . n 
A 1 253 GLN 253 334 334 GLN GLN A . n 
A 1 254 ALA 254 335 335 ALA ALA A . n 
A 1 255 GLY 255 336 336 GLY GLY A . n 
A 1 256 TRP 256 337 337 TRP TRP A . n 
A 1 257 ASP 257 338 338 ASP ASP A . n 
A 1 258 ALA 258 339 339 ALA ALA A . n 
A 1 259 THR 259 340 340 THR THR A . n 
A 1 260 PHE 260 341 341 PHE PHE A . n 
A 1 261 ILE 261 342 342 ILE ILE A . n 
A 1 262 VAL 262 343 343 VAL VAL A . n 
A 1 263 ASP 263 344 344 ASP ASP A . n 
A 1 264 GLN 264 345 345 GLN GLN A . n 
A 1 265 GLY 265 346 346 GLY GLY A . n 
A 1 266 ARG 266 347 347 ARG ARG A . n 
A 1 267 SER 267 348 348 SER SER A . n 
A 1 268 GLY 268 349 349 GLY GLY A . n 
A 1 269 VAL 269 350 350 VAL VAL A . n 
A 1 270 GLN 270 351 351 GLN GLN A . n 
A 1 271 ASN 271 352 352 ASN ASN A . n 
A 1 272 ILE 272 353 353 ILE ILE A . n 
A 1 273 ARG 273 354 354 ARG ARG A . n 
A 1 274 GLN 274 355 355 GLN GLN A . n 
A 1 275 GLN 275 356 356 GLN GLN A . n 
A 1 276 TRP 276 357 357 TRP TRP A . n 
A 1 277 GLY 277 358 358 GLY GLY A . n 
A 1 278 ASP 278 359 359 ASP ASP A . n 
A 1 279 TRP 279 360 360 TRP TRP A . n 
A 1 280 CYS 280 361 361 CYS CYS A . n 
A 1 281 ASN 281 362 362 ASN ASN A . n 
A 1 282 ILE 282 363 363 ILE ILE A . n 
A 1 283 LYS 283 364 364 LYS LYS A . n 
A 1 284 GLY 284 365 365 GLY GLY A . n 
A 1 285 ALA 285 366 366 ALA ALA A . n 
A 1 286 GLY 286 367 367 GLY GLY A . n 
A 1 287 PHE 287 368 368 PHE PHE A . n 
A 1 288 GLY 288 369 369 GLY GLY A . n 
A 1 289 THR 289 370 370 THR THR A . n 
A 1 290 ARG 290 371 371 ARG ARG A . n 
A 1 291 PRO 291 372 372 PRO PRO A . n 
A 1 292 THR 292 373 373 THR THR A . n 
A 1 293 THR 293 374 374 THR THR A . n 
A 1 294 ASN 294 375 375 ASN ASN A . n 
A 1 295 THR 295 376 376 THR THR A . n 
A 1 296 GLY 296 377 377 GLY GLY A . n 
A 1 297 SER 297 378 378 SER SER A . n 
A 1 298 GLN 298 379 379 GLN GLN A . n 
A 1 299 PHE 299 380 380 PHE PHE A . n 
A 1 300 ILE 300 381 381 ILE ILE A . n 
A 1 301 ASP 301 382 382 ASP ASP A . n 
A 1 302 SER 302 383 383 SER SER A . n 
A 1 303 ILE 303 384 384 ILE ILE A . n 
A 1 304 VAL 304 385 385 VAL VAL A . n 
A 1 305 TRP 305 386 386 TRP TRP A . n 
A 1 306 VAL 306 387 387 VAL VAL A . n 
A 1 307 LYS 307 388 388 LYS LYS A . n 
A 1 308 PRO 308 389 389 PRO PRO A . n 
A 1 309 GLY 309 390 390 GLY GLY A . n 
A 1 310 GLY 310 391 391 GLY GLY A . n 
A 1 311 GLU 311 392 392 GLU GLU A . n 
A 1 312 SER 312 393 393 SER SER A . n 
A 1 313 ASP 313 394 394 ASP ASP A . n 
A 1 314 GLY 314 395 395 GLY GLY A . n 
A 1 315 THR 315 396 396 THR THR A . n 
A 1 316 SER 316 397 397 SER SER A . n 
A 1 317 ASN 317 398 398 ASN ASN A . n 
A 1 318 SER 318 399 399 SER SER A . n 
A 1 319 SER 319 400 400 SER SER A . n 
A 1 320 SER 320 401 401 SER SER A . n 
A 1 321 PRO 321 402 402 PRO PRO A . n 
A 1 322 ARG 322 403 403 ARG ARG A . n 
A 1 323 TYR 323 404 404 TYR TYR A . n 
A 1 324 ASP 324 405 405 ASP ASP A . n 
A 1 325 SER 325 406 406 SER SER A . n 
A 1 326 THR 326 407 407 THR THR A . n 
A 1 327 CYS 327 408 408 CYS CYS A . n 
A 1 328 SER 328 409 409 SER SER A . n 
A 1 329 LEU 329 410 410 LEU LEU A . n 
A 1 330 PRO 330 411 411 PRO PRO A . n 
A 1 331 ASP 331 412 412 ASP ASP A . n 
A 1 332 ALA 332 413 413 ALA ALA A . n 
A 1 333 ALA 333 414 414 ALA ALA A . n 
A 1 334 GLN 334 415 415 GLN GLN A . n 
A 1 335 PRO 335 416 416 PRO PRO A . n 
A 1 336 ALA 336 417 417 ALA ALA A . n 
A 1 337 PRO 337 418 418 PRO PRO A . n 
A 1 338 GLU 338 419 419 GLU GLU A . n 
A 1 339 ALA 339 420 420 ALA ALA A . n 
A 1 340 GLY 340 421 421 GLY GLY A . n 
A 1 341 THR 341 422 422 THR THR A . n 
A 1 342 TRP 342 423 423 TRP TRP A . n 
A 1 343 PHE 343 424 424 PHE PHE A . n 
A 1 344 GLN 344 425 425 GLN GLN A . n 
A 1 345 ALA 345 426 426 ALA ALA A . n 
A 1 346 TYR 346 427 427 TYR TYR A . n 
A 1 347 PHE 347 428 428 PHE PHE A . n 
A 1 348 GLN 348 429 429 GLN GLN A . n 
A 1 349 THR 349 430 430 THR THR A . n 
A 1 350 LEU 350 431 431 LEU LEU A . n 
A 1 351 VAL 351 432 432 VAL VAL A . n 
A 1 352 SER 352 433 433 SER SER A . n 
A 1 353 ALA 353 434 434 ALA ALA A . n 
A 1 354 ALA 354 435 435 ALA ALA A . n 
A 1 355 ASN 355 436 436 ASN ASN A . n 
A 1 356 PRO 356 437 437 PRO PRO A . n 
A 1 357 PRO 357 438 438 PRO PRO A . n 
A 1 358 LEU 358 439 439 LEU LEU A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   501 483 HOH HOH A . 
B 2 HOH 2   502 149 HOH HOH A . 
B 2 HOH 3   503 468 HOH HOH A . 
B 2 HOH 4   504 189 HOH HOH A . 
B 2 HOH 5   505 488 HOH HOH A . 
B 2 HOH 6   506 262 HOH HOH A . 
B 2 HOH 7   507 255 HOH HOH A . 
B 2 HOH 8   508 108 HOH HOH A . 
B 2 HOH 9   509 143 HOH HOH A . 
B 2 HOH 10  510 476 HOH HOH A . 
B 2 HOH 11  511 337 HOH HOH A . 
B 2 HOH 12  512 478 HOH HOH A . 
B 2 HOH 13  513 296 HOH HOH A . 
B 2 HOH 14  514 142 HOH HOH A . 
B 2 HOH 15  515 458 HOH HOH A . 
B 2 HOH 16  516 199 HOH HOH A . 
B 2 HOH 17  517 373 HOH HOH A . 
B 2 HOH 18  518 59  HOH HOH A . 
B 2 HOH 19  519 445 HOH HOH A . 
B 2 HOH 20  520 378 HOH HOH A . 
B 2 HOH 21  521 382 HOH HOH A . 
B 2 HOH 22  522 385 HOH HOH A . 
B 2 HOH 23  523 390 HOH HOH A . 
B 2 HOH 24  524 117 HOH HOH A . 
B 2 HOH 25  525 482 HOH HOH A . 
B 2 HOH 26  526 186 HOH HOH A . 
B 2 HOH 27  527 56  HOH HOH A . 
B 2 HOH 28  528 27  HOH HOH A . 
B 2 HOH 29  529 185 HOH HOH A . 
B 2 HOH 30  530 375 HOH HOH A . 
B 2 HOH 31  531 398 HOH HOH A . 
B 2 HOH 32  532 151 HOH HOH A . 
B 2 HOH 33  533 168 HOH HOH A . 
B 2 HOH 34  534 201 HOH HOH A . 
B 2 HOH 35  535 328 HOH HOH A . 
B 2 HOH 36  536 464 HOH HOH A . 
B 2 HOH 37  537 118 HOH HOH A . 
B 2 HOH 38  538 248 HOH HOH A . 
B 2 HOH 39  539 424 HOH HOH A . 
B 2 HOH 40  540 93  HOH HOH A . 
B 2 HOH 41  541 479 HOH HOH A . 
B 2 HOH 42  542 413 HOH HOH A . 
B 2 HOH 43  543 395 HOH HOH A . 
B 2 HOH 44  544 79  HOH HOH A . 
B 2 HOH 45  545 344 HOH HOH A . 
B 2 HOH 46  546 450 HOH HOH A . 
B 2 HOH 47  547 14  HOH HOH A . 
B 2 HOH 48  548 21  HOH HOH A . 
B 2 HOH 49  549 430 HOH HOH A . 
B 2 HOH 50  550 121 HOH HOH A . 
B 2 HOH 51  551 70  HOH HOH A . 
B 2 HOH 52  552 34  HOH HOH A . 
B 2 HOH 53  553 230 HOH HOH A . 
B 2 HOH 54  554 190 HOH HOH A . 
B 2 HOH 55  555 184 HOH HOH A . 
B 2 HOH 56  556 104 HOH HOH A . 
B 2 HOH 57  557 334 HOH HOH A . 
B 2 HOH 58  558 446 HOH HOH A . 
B 2 HOH 59  559 428 HOH HOH A . 
B 2 HOH 60  560 266 HOH HOH A . 
B 2 HOH 61  561 18  HOH HOH A . 
B 2 HOH 62  562 449 HOH HOH A . 
B 2 HOH 63  563 81  HOH HOH A . 
B 2 HOH 64  564 83  HOH HOH A . 
B 2 HOH 65  565 451 HOH HOH A . 
B 2 HOH 66  566 75  HOH HOH A . 
B 2 HOH 67  567 396 HOH HOH A . 
B 2 HOH 68  568 90  HOH HOH A . 
B 2 HOH 69  569 22  HOH HOH A . 
B 2 HOH 70  570 222 HOH HOH A . 
B 2 HOH 71  571 432 HOH HOH A . 
B 2 HOH 72  572 33  HOH HOH A . 
B 2 HOH 73  573 106 HOH HOH A . 
B 2 HOH 74  574 288 HOH HOH A . 
B 2 HOH 75  575 46  HOH HOH A . 
B 2 HOH 76  576 85  HOH HOH A . 
B 2 HOH 77  577 191 HOH HOH A . 
B 2 HOH 78  578 129 HOH HOH A . 
B 2 HOH 79  579 73  HOH HOH A . 
B 2 HOH 80  580 481 HOH HOH A . 
B 2 HOH 81  581 192 HOH HOH A . 
B 2 HOH 82  582 332 HOH HOH A . 
B 2 HOH 83  583 221 HOH HOH A . 
B 2 HOH 84  584 240 HOH HOH A . 
B 2 HOH 85  585 268 HOH HOH A . 
B 2 HOH 86  586 291 HOH HOH A . 
B 2 HOH 87  587 280 HOH HOH A . 
B 2 HOH 88  588 228 HOH HOH A . 
B 2 HOH 89  589 40  HOH HOH A . 
B 2 HOH 90  590 194 HOH HOH A . 
B 2 HOH 91  591 272 HOH HOH A . 
B 2 HOH 92  592 127 HOH HOH A . 
B 2 HOH 93  593 55  HOH HOH A . 
B 2 HOH 94  594 407 HOH HOH A . 
B 2 HOH 95  595 158 HOH HOH A . 
B 2 HOH 96  596 135 HOH HOH A . 
B 2 HOH 97  597 178 HOH HOH A . 
B 2 HOH 98  598 367 HOH HOH A . 
B 2 HOH 99  599 216 HOH HOH A . 
B 2 HOH 100 600 74  HOH HOH A . 
B 2 HOH 101 601 147 HOH HOH A . 
B 2 HOH 102 602 469 HOH HOH A . 
B 2 HOH 103 603 102 HOH HOH A . 
B 2 HOH 104 604 392 HOH HOH A . 
B 2 HOH 105 605 418 HOH HOH A . 
B 2 HOH 106 606 470 HOH HOH A . 
B 2 HOH 107 607 15  HOH HOH A . 
B 2 HOH 108 608 66  HOH HOH A . 
B 2 HOH 109 609 238 HOH HOH A . 
B 2 HOH 110 610 125 HOH HOH A . 
B 2 HOH 111 611 67  HOH HOH A . 
B 2 HOH 112 612 112 HOH HOH A . 
B 2 HOH 113 613 150 HOH HOH A . 
B 2 HOH 114 614 107 HOH HOH A . 
B 2 HOH 115 615 465 HOH HOH A . 
B 2 HOH 116 616 31  HOH HOH A . 
B 2 HOH 117 617 94  HOH HOH A . 
B 2 HOH 118 618 61  HOH HOH A . 
B 2 HOH 119 619 45  HOH HOH A . 
B 2 HOH 120 620 434 HOH HOH A . 
B 2 HOH 121 621 377 HOH HOH A . 
B 2 HOH 122 622 43  HOH HOH A . 
B 2 HOH 123 623 197 HOH HOH A . 
B 2 HOH 124 624 307 HOH HOH A . 
B 2 HOH 125 625 175 HOH HOH A . 
B 2 HOH 126 626 317 HOH HOH A . 
B 2 HOH 127 627 370 HOH HOH A . 
B 2 HOH 128 628 205 HOH HOH A . 
B 2 HOH 129 629 366 HOH HOH A . 
B 2 HOH 130 630 137 HOH HOH A . 
B 2 HOH 131 631 269 HOH HOH A . 
B 2 HOH 132 632 311 HOH HOH A . 
B 2 HOH 133 633 301 HOH HOH A . 
B 2 HOH 134 634 37  HOH HOH A . 
B 2 HOH 135 635 131 HOH HOH A . 
B 2 HOH 136 636 323 HOH HOH A . 
B 2 HOH 137 637 306 HOH HOH A . 
B 2 HOH 138 638 24  HOH HOH A . 
B 2 HOH 139 639 225 HOH HOH A . 
B 2 HOH 140 640 86  HOH HOH A . 
B 2 HOH 141 641 187 HOH HOH A . 
B 2 HOH 142 642 486 HOH HOH A . 
B 2 HOH 143 643 242 HOH HOH A . 
B 2 HOH 144 644 96  HOH HOH A . 
B 2 HOH 145 645 28  HOH HOH A . 
B 2 HOH 146 646 57  HOH HOH A . 
B 2 HOH 147 647 326 HOH HOH A . 
B 2 HOH 148 648 172 HOH HOH A . 
B 2 HOH 149 649 12  HOH HOH A . 
B 2 HOH 150 650 246 HOH HOH A . 
B 2 HOH 151 651 414 HOH HOH A . 
B 2 HOH 152 652 439 HOH HOH A . 
B 2 HOH 153 653 100 HOH HOH A . 
B 2 HOH 154 654 98  HOH HOH A . 
B 2 HOH 155 655 53  HOH HOH A . 
B 2 HOH 156 656 2   HOH HOH A . 
B 2 HOH 157 657 170 HOH HOH A . 
B 2 HOH 158 658 120 HOH HOH A . 
B 2 HOH 159 659 287 HOH HOH A . 
B 2 HOH 160 660 310 HOH HOH A . 
B 2 HOH 161 661 41  HOH HOH A . 
B 2 HOH 162 662 148 HOH HOH A . 
B 2 HOH 163 663 153 HOH HOH A . 
B 2 HOH 164 664 58  HOH HOH A . 
B 2 HOH 165 665 54  HOH HOH A . 
B 2 HOH 166 666 49  HOH HOH A . 
B 2 HOH 167 667 174 HOH HOH A . 
B 2 HOH 168 668 363 HOH HOH A . 
B 2 HOH 169 669 259 HOH HOH A . 
B 2 HOH 170 670 16  HOH HOH A . 
B 2 HOH 171 671 110 HOH HOH A . 
B 2 HOH 172 672 220 HOH HOH A . 
B 2 HOH 173 673 115 HOH HOH A . 
B 2 HOH 174 674 208 HOH HOH A . 
B 2 HOH 175 675 63  HOH HOH A . 
B 2 HOH 176 676 119 HOH HOH A . 
B 2 HOH 177 677 212 HOH HOH A . 
B 2 HOH 178 678 4   HOH HOH A . 
B 2 HOH 179 679 441 HOH HOH A . 
B 2 HOH 180 680 3   HOH HOH A . 
B 2 HOH 181 681 206 HOH HOH A . 
B 2 HOH 182 682 308 HOH HOH A . 
B 2 HOH 183 683 17  HOH HOH A . 
B 2 HOH 184 684 415 HOH HOH A . 
B 2 HOH 185 685 20  HOH HOH A . 
B 2 HOH 186 686 111 HOH HOH A . 
B 2 HOH 187 687 50  HOH HOH A . 
B 2 HOH 188 688 320 HOH HOH A . 
B 2 HOH 189 689 236 HOH HOH A . 
B 2 HOH 190 690 19  HOH HOH A . 
B 2 HOH 191 691 214 HOH HOH A . 
B 2 HOH 192 692 183 HOH HOH A . 
B 2 HOH 193 693 10  HOH HOH A . 
B 2 HOH 194 694 179 HOH HOH A . 
B 2 HOH 195 695 25  HOH HOH A . 
B 2 HOH 196 696 5   HOH HOH A . 
B 2 HOH 197 697 39  HOH HOH A . 
B 2 HOH 198 698 77  HOH HOH A . 
B 2 HOH 199 699 200 HOH HOH A . 
B 2 HOH 200 700 101 HOH HOH A . 
B 2 HOH 201 701 78  HOH HOH A . 
B 2 HOH 202 702 62  HOH HOH A . 
B 2 HOH 203 703 6   HOH HOH A . 
B 2 HOH 204 704 176 HOH HOH A . 
B 2 HOH 205 705 290 HOH HOH A . 
B 2 HOH 206 706 283 HOH HOH A . 
B 2 HOH 207 707 88  HOH HOH A . 
B 2 HOH 208 708 250 HOH HOH A . 
B 2 HOH 209 709 87  HOH HOH A . 
B 2 HOH 210 710 410 HOH HOH A . 
B 2 HOH 211 711 160 HOH HOH A . 
B 2 HOH 212 712 371 HOH HOH A . 
B 2 HOH 213 713 177 HOH HOH A . 
B 2 HOH 214 714 239 HOH HOH A . 
B 2 HOH 215 715 267 HOH HOH A . 
B 2 HOH 216 716 146 HOH HOH A . 
B 2 HOH 217 717 380 HOH HOH A . 
B 2 HOH 218 718 51  HOH HOH A . 
B 2 HOH 219 719 321 HOH HOH A . 
B 2 HOH 220 720 136 HOH HOH A . 
B 2 HOH 221 721 36  HOH HOH A . 
B 2 HOH 222 722 155 HOH HOH A . 
B 2 HOH 223 723 114 HOH HOH A . 
B 2 HOH 224 724 400 HOH HOH A . 
B 2 HOH 225 725 9   HOH HOH A . 
B 2 HOH 226 726 224 HOH HOH A . 
B 2 HOH 227 727 91  HOH HOH A . 
B 2 HOH 228 728 97  HOH HOH A . 
B 2 HOH 229 729 144 HOH HOH A . 
B 2 HOH 230 730 157 HOH HOH A . 
B 2 HOH 231 731 180 HOH HOH A . 
B 2 HOH 232 732 11  HOH HOH A . 
B 2 HOH 233 733 394 HOH HOH A . 
B 2 HOH 234 734 68  HOH HOH A . 
B 2 HOH 235 735 433 HOH HOH A . 
B 2 HOH 236 736 7   HOH HOH A . 
B 2 HOH 237 737 217 HOH HOH A . 
B 2 HOH 238 738 340 HOH HOH A . 
B 2 HOH 239 739 345 HOH HOH A . 
B 2 HOH 240 740 274 HOH HOH A . 
B 2 HOH 241 741 154 HOH HOH A . 
B 2 HOH 242 742 202 HOH HOH A . 
B 2 HOH 243 743 232 HOH HOH A . 
B 2 HOH 244 744 331 HOH HOH A . 
B 2 HOH 245 745 1   HOH HOH A . 
B 2 HOH 246 746 264 HOH HOH A . 
B 2 HOH 247 747 141 HOH HOH A . 
B 2 HOH 248 748 241 HOH HOH A . 
B 2 HOH 249 749 273 HOH HOH A . 
B 2 HOH 250 750 472 HOH HOH A . 
B 2 HOH 251 751 99  HOH HOH A . 
B 2 HOH 252 752 276 HOH HOH A . 
B 2 HOH 253 753 210 HOH HOH A . 
B 2 HOH 254 754 365 HOH HOH A . 
B 2 HOH 255 755 457 HOH HOH A . 
B 2 HOH 256 756 324 HOH HOH A . 
B 2 HOH 257 757 42  HOH HOH A . 
B 2 HOH 258 758 138 HOH HOH A . 
B 2 HOH 259 759 92  HOH HOH A . 
B 2 HOH 260 760 364 HOH HOH A . 
B 2 HOH 261 761 123 HOH HOH A . 
B 2 HOH 262 762 23  HOH HOH A . 
B 2 HOH 263 763 203 HOH HOH A . 
B 2 HOH 264 764 65  HOH HOH A . 
B 2 HOH 265 765 292 HOH HOH A . 
B 2 HOH 266 766 237 HOH HOH A . 
B 2 HOH 267 767 105 HOH HOH A . 
B 2 HOH 268 768 124 HOH HOH A . 
B 2 HOH 269 769 285 HOH HOH A . 
B 2 HOH 270 770 223 HOH HOH A . 
B 2 HOH 271 771 47  HOH HOH A . 
B 2 HOH 272 772 305 HOH HOH A . 
B 2 HOH 273 773 139 HOH HOH A . 
B 2 HOH 274 774 318 HOH HOH A . 
B 2 HOH 275 775 82  HOH HOH A . 
B 2 HOH 276 776 132 HOH HOH A . 
B 2 HOH 277 777 165 HOH HOH A . 
B 2 HOH 278 778 113 HOH HOH A . 
B 2 HOH 279 779 30  HOH HOH A . 
B 2 HOH 280 780 163 HOH HOH A . 
B 2 HOH 281 781 166 HOH HOH A . 
B 2 HOH 282 782 343 HOH HOH A . 
B 2 HOH 283 783 35  HOH HOH A . 
B 2 HOH 284 784 207 HOH HOH A . 
B 2 HOH 285 785 349 HOH HOH A . 
B 2 HOH 286 786 116 HOH HOH A . 
B 2 HOH 287 787 420 HOH HOH A . 
B 2 HOH 288 788 134 HOH HOH A . 
B 2 HOH 289 789 76  HOH HOH A . 
B 2 HOH 290 790 64  HOH HOH A . 
B 2 HOH 291 791 234 HOH HOH A . 
B 2 HOH 292 792 489 HOH HOH A . 
B 2 HOH 293 793 173 HOH HOH A . 
B 2 HOH 294 794 376 HOH HOH A . 
B 2 HOH 295 795 339 HOH HOH A . 
B 2 HOH 296 796 72  HOH HOH A . 
B 2 HOH 297 797 71  HOH HOH A . 
B 2 HOH 298 798 229 HOH HOH A . 
B 2 HOH 299 799 48  HOH HOH A . 
B 2 HOH 300 800 26  HOH HOH A . 
B 2 HOH 301 801 327 HOH HOH A . 
B 2 HOH 302 802 182 HOH HOH A . 
B 2 HOH 303 803 463 HOH HOH A . 
B 2 HOH 304 804 484 HOH HOH A . 
B 2 HOH 305 805 372 HOH HOH A . 
B 2 HOH 306 806 219 HOH HOH A . 
B 2 HOH 307 807 95  HOH HOH A . 
B 2 HOH 308 808 313 HOH HOH A . 
B 2 HOH 309 809 281 HOH HOH A . 
B 2 HOH 310 810 140 HOH HOH A . 
B 2 HOH 311 811 354 HOH HOH A . 
B 2 HOH 312 812 52  HOH HOH A . 
B 2 HOH 313 813 333 HOH HOH A . 
B 2 HOH 314 814 233 HOH HOH A . 
B 2 HOH 315 815 299 HOH HOH A . 
B 2 HOH 316 816 193 HOH HOH A . 
B 2 HOH 317 817 338 HOH HOH A . 
B 2 HOH 318 818 169 HOH HOH A . 
B 2 HOH 319 819 335 HOH HOH A . 
B 2 HOH 320 820 460 HOH HOH A . 
B 2 HOH 321 821 8   HOH HOH A . 
B 2 HOH 322 822 429 HOH HOH A . 
B 2 HOH 323 823 13  HOH HOH A . 
B 2 HOH 324 824 213 HOH HOH A . 
B 2 HOH 325 825 312 HOH HOH A . 
B 2 HOH 326 826 245 HOH HOH A . 
B 2 HOH 327 827 448 HOH HOH A . 
B 2 HOH 328 828 325 HOH HOH A . 
B 2 HOH 329 829 69  HOH HOH A . 
B 2 HOH 330 830 444 HOH HOH A . 
B 2 HOH 331 831 319 HOH HOH A . 
B 2 HOH 332 832 128 HOH HOH A . 
B 2 HOH 333 833 329 HOH HOH A . 
B 2 HOH 334 834 411 HOH HOH A . 
B 2 HOH 335 835 391 HOH HOH A . 
B 2 HOH 336 836 60  HOH HOH A . 
B 2 HOH 337 837 475 HOH HOH A . 
B 2 HOH 338 838 456 HOH HOH A . 
B 2 HOH 339 839 360 HOH HOH A . 
B 2 HOH 340 840 265 HOH HOH A . 
B 2 HOH 341 841 477 HOH HOH A . 
B 2 HOH 342 842 336 HOH HOH A . 
B 2 HOH 343 843 348 HOH HOH A . 
B 2 HOH 344 844 227 HOH HOH A . 
B 2 HOH 345 845 204 HOH HOH A . 
B 2 HOH 346 846 357 HOH HOH A . 
B 2 HOH 347 847 459 HOH HOH A . 
B 2 HOH 348 848 440 HOH HOH A . 
B 2 HOH 349 849 278 HOH HOH A . 
B 2 HOH 350 850 379 HOH HOH A . 
B 2 HOH 351 851 38  HOH HOH A . 
B 2 HOH 352 852 342 HOH HOH A . 
B 2 HOH 353 853 122 HOH HOH A . 
B 2 HOH 354 854 402 HOH HOH A . 
B 2 HOH 355 855 471 HOH HOH A . 
B 2 HOH 356 856 443 HOH HOH A . 
B 2 HOH 357 857 253 HOH HOH A . 
B 2 HOH 358 858 226 HOH HOH A . 
B 2 HOH 359 859 442 HOH HOH A . 
B 2 HOH 360 860 256 HOH HOH A . 
B 2 HOH 361 861 260 HOH HOH A . 
B 2 HOH 362 862 279 HOH HOH A . 
B 2 HOH 363 863 198 HOH HOH A . 
B 2 HOH 364 864 32  HOH HOH A . 
B 2 HOH 365 865 196 HOH HOH A . 
B 2 HOH 366 866 474 HOH HOH A . 
B 2 HOH 367 867 145 HOH HOH A . 
B 2 HOH 368 868 275 HOH HOH A . 
B 2 HOH 369 869 487 HOH HOH A . 
B 2 HOH 370 870 388 HOH HOH A . 
B 2 HOH 371 871 171 HOH HOH A . 
B 2 HOH 372 872 435 HOH HOH A . 
B 2 HOH 373 873 247 HOH HOH A . 
B 2 HOH 374 874 211 HOH HOH A . 
B 2 HOH 375 875 381 HOH HOH A . 
B 2 HOH 376 876 309 HOH HOH A . 
B 2 HOH 377 877 209 HOH HOH A . 
B 2 HOH 378 878 195 HOH HOH A . 
B 2 HOH 379 879 231 HOH HOH A . 
B 2 HOH 380 880 437 HOH HOH A . 
B 2 HOH 381 881 401 HOH HOH A . 
B 2 HOH 382 882 130 HOH HOH A . 
B 2 HOH 383 883 316 HOH HOH A . 
B 2 HOH 384 884 419 HOH HOH A . 
B 2 HOH 385 885 156 HOH HOH A . 
B 2 HOH 386 886 270 HOH HOH A . 
B 2 HOH 387 887 314 HOH HOH A . 
B 2 HOH 388 888 347 HOH HOH A . 
B 2 HOH 389 889 161 HOH HOH A . 
B 2 HOH 390 890 386 HOH HOH A . 
B 2 HOH 391 891 286 HOH HOH A . 
B 2 HOH 392 892 289 HOH HOH A . 
B 2 HOH 393 893 263 HOH HOH A . 
B 2 HOH 394 894 294 HOH HOH A . 
B 2 HOH 395 895 249 HOH HOH A . 
B 2 HOH 396 896 403 HOH HOH A . 
B 2 HOH 397 897 188 HOH HOH A . 
B 2 HOH 398 898 284 HOH HOH A . 
B 2 HOH 399 899 421 HOH HOH A . 
B 2 HOH 400 900 355 HOH HOH A . 
B 2 HOH 401 901 282 HOH HOH A . 
B 2 HOH 402 902 315 HOH HOH A . 
B 2 HOH 403 903 251 HOH HOH A . 
B 2 HOH 404 904 352 HOH HOH A . 
B 2 HOH 405 905 133 HOH HOH A . 
B 2 HOH 406 906 427 HOH HOH A . 
B 2 HOH 407 907 353 HOH HOH A . 
B 2 HOH 408 908 300 HOH HOH A . 
B 2 HOH 409 909 368 HOH HOH A . 
B 2 HOH 410 910 426 HOH HOH A . 
B 2 HOH 411 911 277 HOH HOH A . 
B 2 HOH 412 912 252 HOH HOH A . 
B 2 HOH 413 913 80  HOH HOH A . 
B 2 HOH 414 914 293 HOH HOH A . 
B 2 HOH 415 915 258 HOH HOH A . 
B 2 HOH 416 916 152 HOH HOH A . 
B 2 HOH 417 917 297 HOH HOH A . 
B 2 HOH 418 918 462 HOH HOH A . 
B 2 HOH 419 919 454 HOH HOH A . 
B 2 HOH 420 920 356 HOH HOH A . 
B 2 HOH 421 921 218 HOH HOH A . 
B 2 HOH 422 922 322 HOH HOH A . 
B 2 HOH 423 923 181 HOH HOH A . 
B 2 HOH 424 924 126 HOH HOH A . 
B 2 HOH 425 925 44  HOH HOH A . 
B 2 HOH 426 926 350 HOH HOH A . 
B 2 HOH 427 927 330 HOH HOH A . 
B 2 HOH 428 928 304 HOH HOH A . 
B 2 HOH 429 929 405 HOH HOH A . 
B 2 HOH 430 930 422 HOH HOH A . 
B 2 HOH 431 931 295 HOH HOH A . 
B 2 HOH 432 932 383 HOH HOH A . 
B 2 HOH 433 933 393 HOH HOH A . 
B 2 HOH 434 934 215 HOH HOH A . 
B 2 HOH 435 935 397 HOH HOH A . 
B 2 HOH 436 936 374 HOH HOH A . 
B 2 HOH 437 937 369 HOH HOH A . 
B 2 HOH 438 938 303 HOH HOH A . 
B 2 HOH 439 939 159 HOH HOH A . 
B 2 HOH 440 940 351 HOH HOH A . 
B 2 HOH 441 941 387 HOH HOH A . 
B 2 HOH 442 942 302 HOH HOH A . 
B 2 HOH 443 943 431 HOH HOH A . 
B 2 HOH 444 944 473 HOH HOH A . 
B 2 HOH 445 945 404 HOH HOH A . 
B 2 HOH 446 946 162 HOH HOH A . 
B 2 HOH 447 947 271 HOH HOH A . 
B 2 HOH 448 948 341 HOH HOH A . 
B 2 HOH 449 949 436 HOH HOH A . 
B 2 HOH 450 950 384 HOH HOH A . 
B 2 HOH 451 951 455 HOH HOH A . 
B 2 HOH 452 952 167 HOH HOH A . 
B 2 HOH 453 953 480 HOH HOH A . 
B 2 HOH 454 954 452 HOH HOH A . 
B 2 HOH 455 955 447 HOH HOH A . 
B 2 HOH 456 956 358 HOH HOH A . 
B 2 HOH 457 957 425 HOH HOH A . 
B 2 HOH 458 958 423 HOH HOH A . 
B 2 HOH 459 959 261 HOH HOH A . 
B 2 HOH 460 960 412 HOH HOH A . 
B 2 HOH 461 961 467 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8WYV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     54.329 
_cell.length_a_esd                 ? 
_cell.length_b                     67.466 
_cell.length_b_esd                 ? 
_cell.length_c                     88.266 
_cell.length_c_esd                 ? 
_cell.volume                       323526.693 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8WYV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8WYV 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.11 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.66 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG 4000, sodium acetate, sodium chloride' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     95 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 S 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-03-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-5A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-5A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          11.91 
_reflns.entry_id                                       8WYV 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.14 
_reflns.d_resolution_low                               46.27 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     118664 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          21.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.059 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.14 
_reflns_shell.d_res_low                                     1.16 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.2 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5798 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               11.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.7 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.177 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               15.52 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8WYV 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.14 
_refine.ls_d_res_low                             46.27 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     118551 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  116551 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.91 
_refine.ls_percent_reflns_R_free                 1.69 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1668 
_refine.ls_R_factor_R_free                       0.1797 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1666 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 17.8272 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.0722 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.14 
_refine_hist.d_res_low                        46.27 
_refine_hist.number_atoms_solvent             461 
_refine_hist.number_atoms_total               3172 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2711 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0050 ? 3681 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8436 ? 5106 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0810 ? 565  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0065 ? 694  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.6738 ? 536  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.14 1.17  . . 140 8198 99.49  . . . . 0.2354 . . . . . . . . . . . 0.2362 
'X-RAY DIFFRACTION' 1.17 1.20  . . 142 8236 99.83  . . . . 0.2163 . . . . . . . . . . . 0.2494 
'X-RAY DIFFRACTION' 1.20 1.24  . . 141 8259 99.83  . . . . 0.2156 . . . . . . . . . . . 0.2331 
'X-RAY DIFFRACTION' 1.24 1.28  . . 142 8221 99.92  . . . . 0.1995 . . . . . . . . . . . 0.2269 
'X-RAY DIFFRACTION' 1.28 1.32  . . 141 8256 99.98  . . . . 0.1903 . . . . . . . . . . . 0.1996 
'X-RAY DIFFRACTION' 1.32 1.37  . . 143 8278 100.00 . . . . 0.1799 . . . . . . . . . . . 0.1956 
'X-RAY DIFFRACTION' 1.37 1.44  . . 141 8274 100.00 . . . . 0.1740 . . . . . . . . . . . 0.1865 
'X-RAY DIFFRACTION' 1.44 1.51  . . 142 8268 99.99  . . . . 0.1642 . . . . . . . . . . . 0.1722 
'X-RAY DIFFRACTION' 1.51 1.61  . . 143 8340 100.00 . . . . 0.1619 . . . . . . . . . . . 0.1785 
'X-RAY DIFFRACTION' 1.61 1.73  . . 143 8323 99.99  . . . . 0.1603 . . . . . . . . . . . 0.1981 
'X-RAY DIFFRACTION' 1.73 1.91  . . 143 8324 100.00 . . . . 0.1623 . . . . . . . . . . . 0.1821 
'X-RAY DIFFRACTION' 1.91 2.18  . . 144 8403 99.94  . . . . 0.1578 . . . . . . . . . . . 0.1758 
'X-RAY DIFFRACTION' 2.18 2.75  . . 145 8439 99.93  . . . . 0.1659 . . . . . . . . . . . 0.1833 
'X-RAY DIFFRACTION' 2.75 46.27 . . 150 8732 99.83  . . . . 0.1548 . . . . . . . . . . . 0.1567 
# 
_struct.entry_id                     8WYV 
_struct.title                        
;X-Ray crystal structure of glycoside hydrolase family 6 cellobiohydrolase from Phanerochaete chrysosporium PcCel6A D170N/S176V/C240S/C393S
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8WYV 
_struct_keywords.text            'Glycoside hydrolase family 6, cellobiohydrolase, cellulase, catalytic domain, mutant, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    H3K419_PHACH 
_struct_ref.pdbx_db_accession          H3K419 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLACV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGECDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_struct_ref.pdbx_align_begin           82 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8WYV 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 358 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             H3K419 
_struct_ref_seq.db_align_beg                  82 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  439 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       82 
_struct_ref_seq.pdbx_auth_seq_align_end       439 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8WYV ASN A 89  ? UNP H3K419 ASP 170 'engineered mutation' 170 1 
1 8WYV VAL A 95  ? UNP H3K419 SER 176 'engineered mutation' 176 2 
1 8WYV SER A 159 ? UNP H3K419 CYS 240 'engineered mutation' 240 3 
1 8WYV SER A 312 ? UNP H3K419 CYS 393 'engineered mutation' 393 4 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                
;Software (PISA) determined protein interfaces have not revealed any specific interactions that could form stable quaternary structures.
;
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 14  ? LYS A 26  ? SER A 95  LYS A 107 1 ? 13 
HELX_P HELX_P2  AA2 ASP A 30  ? VAL A 40  ? ASP A 111 VAL A 121 1 ? 11 
HELX_P HELX_P3  AA3 ALA A 41  ? ILE A 43  ? ALA A 122 ILE A 124 5 ? 3  
HELX_P HELX_P4  AA4 SER A 51  ? ALA A 53  ? SER A 132 ALA A 134 5 ? 3  
HELX_P HELX_P5  AA5 LYS A 54  ? GLY A 73  ? LYS A 135 GLY A 154 1 ? 20 
HELX_P HELX_P6  AA6 ASN A 104 ? GLN A 121 ? ASN A 185 GLN A 202 1 ? 18 
HELX_P HELX_P7  AA7 SER A 136 ? ASN A 143 ? SER A 217 ASN A 224 1 ? 8  
HELX_P HELX_P8  AA8 VAL A 146 ? LYS A 169 ? VAL A 227 LYS A 250 1 ? 24 
HELX_P HELX_P9  AA9 TRP A 186 ? ALA A 204 ? TRP A 267 ALA A 285 1 ? 19 
HELX_P HELX_P10 AB1 ASP A 229 ? GLN A 233 ? ASP A 310 GLN A 314 5 ? 5  
HELX_P HELX_P11 AB2 ASP A 239 ? ALA A 254 ? ASP A 320 ALA A 335 1 ? 16 
HELX_P HELX_P12 AB3 ASP A 324 ? LEU A 329 ? ASP A 405 LEU A 410 5 ? 6  
HELX_P HELX_P13 AB4 PHE A 343 ? ALA A 353 ? PHE A 424 ALA A 434 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 90  SG ? ? ? 1_555 A CYS 149 SG ? ? A CYS 171 A CYS 230 1_555 ? ? ? ? ? ? ? 2.069 ? ? 
disulf2 disulf ? ? A CYS 280 SG ? ? ? 1_555 A CYS 327 SG ? ? A CYS 361 A CYS 408 1_555 ? ? ? ? ? ? ? 2.043 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 90  ? CYS A 149 ? CYS A 171 ? 1_555 CYS A 230 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 280 ? CYS A 327 ? CYS A 361 ? 1_555 CYS A 408 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLN 334 A . ? GLN 415 A PRO 335 A ? PRO 416 A 1 -4.15 
2 ASN 355 A . ? ASN 436 A PRO 356 A ? PRO 437 A 1 1.65  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA2 3 4 ? parallel 
AA2 4 5 ? parallel 
AA2 5 6 ? parallel 
AA2 6 7 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 10  ? ILE A 11  ? GLN A 91  ILE A 92  
AA1 2 GLN A 76  ? ILE A 82  ? GLN A 157 ILE A 163 
AA1 3 THR A 47  ? LEU A 49  ? THR A 128 LEU A 130 
AA2 1 GLN A 10  ? ILE A 11  ? GLN A 91  ILE A 92  
AA2 2 GLN A 76  ? ILE A 82  ? GLN A 157 ILE A 163 
AA2 3 ARG A 127 ? ILE A 132 ? ARG A 208 ILE A 213 
AA2 4 TYR A 173 ? ASP A 177 ? TYR A 254 ASP A 258 
AA2 5 ILE A 210 ? THR A 215 ? ILE A 291 THR A 296 
AA2 6 THR A 259 ? ASP A 263 ? THR A 340 ASP A 344 
AA2 7 ILE A 300 ? VAL A 304 ? ILE A 381 VAL A 385 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 10  ? N GLN A 91  O LEU A 77  ? O LEU A 158 
AA1 2 3 O VAL A 81  ? O VAL A 162 N LEU A 49  ? N LEU A 130 
AA2 1 2 N GLN A 10  ? N GLN A 91  O LEU A 77  ? O LEU A 158 
AA2 2 3 N ILE A 82  ? N ILE A 163 O VAL A 131 ? O VAL A 212 
AA2 3 4 N ALA A 130 ? N ALA A 211 O TYR A 173 ? O TYR A 254 
AA2 4 5 N MET A 176 ? N MET A 257 O GLY A 212 ? O GLY A 293 
AA2 5 6 N THR A 215 ? N THR A 296 O ILE A 261 ? O ILE A 342 
AA2 6 7 N VAL A 262 ? N VAL A 343 O VAL A 304 ? O VAL A 385 
# 
_pdbx_entry_details.entry_id                   8WYV 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 THR A 88  ? B -42.68  -70.18  
2  1 TYR A 164 ? ? -151.38 68.73   
3  1 ASP A 165 ? ? -148.20 32.55   
4  1 ASN A 170 ? B 46.86   72.17   
5  1 LYS A 174 ? B -74.57  -90.54  
6  1 ALA A 175 ? A 80.17   154.87  
7  1 GLU A 179 ? B -152.74 -33.06  
8  1 ASN A 184 ? A -118.40 67.25   
9  1 ASN A 184 ? B -117.01 70.69   
10 1 GLU A 214 ? ? 52.79   71.81   
11 1 GLU A 214 ? ? 52.79   76.25   
12 1 SER A 217 ? A -128.85 -82.45  
13 1 SER A 217 ? B -113.80 -90.27  
14 1 TRP A 264 ? ? -109.84 -72.97  
15 1 ASN A 300 ? ? -114.34 -164.62 
16 1 ALA A 335 ? B -110.81 61.64   
17 1 ASP A 338 ? B -64.22  81.35   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       961 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.99 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           22J12651 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5XCY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8WYV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018406 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014822 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011329 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? 27.06254  -25.72285 -23.57038 1.000 20.81699 ? 82  SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? 27.76047  -26.62692 -22.66442 1.000 20.16388 ? 82  SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? 26.98736  -27.93861 -22.58567 1.000 18.06397 ? 82  SER A C   1 
ATOM   4    O O   . SER A 1 1   ? 25.90721  -28.08097 -23.16390 1.000 20.03462 ? 82  SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? 27.86980  -26.00621 -21.27162 1.000 18.40220 ? 82  SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? 26.58595  -25.64330 -20.79424 1.000 22.19984 ? 82  SER A OG  1 
ATOM   7    N N   . ALA A 1 2   ? 27.54142  -28.90004 -21.84660 1.000 14.57708 ? 83  ALA A N   1 
ATOM   8    C CA  . ALA A 1 2   ? 26.88148  -30.19400 -21.71719 1.000 12.48460 ? 83  ALA A CA  1 
ATOM   9    C C   . ALA A 1 2   ? 25.58592  -30.09136 -20.92374 1.000 12.39093 ? 83  ALA A C   1 
ATOM   10   O O   . ALA A 1 2   ? 24.61847  -30.81247 -21.20556 1.000 13.12581 ? 83  ALA A O   1 
ATOM   11   C CB  . ALA A 1 2   ? 27.82317  -31.18728 -21.04663 1.000 13.74735 ? 83  ALA A CB  1 
ATOM   12   N N   . ASN A 1 3   ? 25.56232  -29.23866 -19.91077 1.000 11.33260 ? 84  ASN A N   1 
ATOM   13   C CA  . ASN A 1 3   ? 24.46829  -29.19330 -18.95051 1.000 10.09801 ? 84  ASN A CA  1 
ATOM   14   C C   . ASN A 1 3   ? 23.68936  -27.89705 -19.16843 1.000 10.67515 ? 84  ASN A C   1 
ATOM   15   O O   . ASN A 1 3   ? 24.07181  -26.83836 -18.65825 1.000 12.23690 ? 84  ASN A O   1 
ATOM   16   C CB  . ASN A 1 3   ? 25.02296  -29.25166 -17.53265 1.000 12.15590 ? 84  ASN A CB  1 
ATOM   17   C CG  . ASN A 1 3   ? 23.94051  -29.20901 -16.48695 1.000 12.54773 ? 84  ASN A CG  1 
ATOM   18   O OD1 . ASN A 1 3   ? 22.78906  -29.57293 -16.75581 1.000 16.30690 ? 84  ASN A OD1 1 
ATOM   19   N ND2 . ASN A 1 3   ? 24.26148  -28.67708 -15.32340 1.000 13.58453 ? 84  ASN A ND2 1 
ATOM   20   N N   . ASN A 1 4   ? 22.61365  -27.98202 -19.93315 1.000 10.32074 ? 85  ASN A N   1 
ATOM   21   C CA  . ASN A 1 4   ? 21.70851  -26.85609 -20.10408 1.000 9.46121  ? 85  ASN A CA  1 
ATOM   22   C C   . ASN A 1 4   ? 20.67634  -26.93237 -18.98933 1.000 9.61685  ? 85  ASN A C   1 
ATOM   23   O O   . ASN A 1 4   ? 19.94515  -27.92672 -18.91546 1.000 10.11152 ? 85  ASN A O   1 
ATOM   24   C CB  . ASN A 1 4   ? 21.02515  -26.96598 -21.45389 1.000 10.54705 ? 85  ASN A CB  1 
ATOM   25   C CG  . ASN A 1 4   ? 20.14123  -25.78413 -21.75577 1.000 9.27402  ? 85  ASN A CG  1 
ATOM   26   O OD1 . ASN A 1 4   ? 19.41974  -25.28833 -20.87656 1.000 11.12742 ? 85  ASN A OD1 1 
ATOM   27   N ND2 . ASN A 1 4   ? 20.17532  -25.32625 -23.00154 1.000 10.15695 ? 85  ASN A ND2 1 
ATOM   28   N N   . PRO A 1 5   ? 20.56201  -25.92306 -18.12029 1.000 9.61950  ? 86  PRO A N   1 
ATOM   29   C CA  . PRO A 1 5   ? 19.66239  -26.06667 -16.96006 1.000 10.55494 ? 86  PRO A CA  1 
ATOM   30   C C   . PRO A 1 5   ? 18.22929  -26.42106 -17.31114 1.000 9.50935  ? 86  PRO A C   1 
ATOM   31   O O   . PRO A 1 5   ? 17.53088  -27.02617 -16.48826 1.000 10.67892 ? 86  PRO A O   1 
ATOM   32   C CB  . PRO A 1 5   ? 19.77417  -24.70027 -16.26643 1.000 10.64855 ? 86  PRO A CB  1 
ATOM   33   C CG  . PRO A 1 5   ? 21.16372  -24.24971 -16.61445 1.000 10.99413 ? 86  PRO A CG  1 
ATOM   34   C CD  . PRO A 1 5   ? 21.32381  -24.66146 -18.05207 1.000 10.34981 ? 86  PRO A CD  1 
ATOM   35   N N   . TRP A 1 6   ? 17.76273  -26.03559 -18.49411 1.000 9.33275  ? 87  TRP A N   1 
ATOM   36   C CA  . TRP A 1 6   ? 16.36551  -26.23697 -18.86244 1.000 10.73850 ? 87  TRP A CA  1 
ATOM   37   C C   . TRP A 1 6   ? 16.06355  -27.61825 -19.42893 1.000 11.05784 ? 87  TRP A C   1 
ATOM   38   O O   . TRP A 1 6   ? 14.90756  -28.04264 -19.37716 1.000 11.63812 ? 87  TRP A O   1 
ATOM   39   C CB  . TRP A 1 6   ? 15.92314  -25.18435 -19.88546 1.000 10.57145 ? 87  TRP A CB  1 
ATOM   40   C CG  . TRP A 1 6   ? 15.63027  -23.88618 -19.22666 1.000 9.98779  ? 87  TRP A CG  1 
ATOM   41   C CD1 . TRP A 1 6   ? 14.43655  -23.49519 -18.70163 1.000 11.25365 ? 87  TRP A CD1 1 
ATOM   42   C CD2 . TRP A 1 6   ? 16.55504  -22.82486 -18.95128 1.000 10.07544 ? 87  TRP A CD2 1 
ATOM   43   N NE1 . TRP A 1 6   ? 14.54476  -22.25349 -18.13105 1.000 11.94083 ? 87  TRP A NE1 1 
ATOM   44   C CE2 . TRP A 1 6   ? 15.83180  -21.81282 -18.27690 1.000 10.40926 ? 87  TRP A CE2 1 
ATOM   45   C CE3 . TRP A 1 6   ? 17.91364  -22.62398 -19.22821 1.000 10.26126 ? 87  TRP A CE3 1 
ATOM   46   C CZ2 . TRP A 1 6   ? 16.41804  -20.63512 -17.86443 1.000 10.90747 ? 87  TRP A CZ2 1 
ATOM   47   C CZ3 . TRP A 1 6   ? 18.50027  -21.45619 -18.81350 1.000 11.60036 ? 87  TRP A CZ3 1 
ATOM   48   C CH2 . TRP A 1 6   ? 17.74555  -20.46548 -18.13997 1.000 11.79015 ? 87  TRP A CH2 1 
ATOM   49   N N   A THR A 1 7   ? 17.03921  -28.30468 -20.01147 0.658 11.23724 ? 88  THR A N   1 
ATOM   50   N N   B THR A 1 7   ? 17.06719  -28.35070 -19.92116 0.342 11.38423 ? 88  THR A N   1 
ATOM   51   C CA  A THR A 1 7   ? 16.71447  -29.55494 -20.68516 0.658 11.92886 ? 88  THR A CA  1 
ATOM   52   C CA  B THR A 1 7   ? 16.84571  -29.58281 -20.68746 0.342 11.92747 ? 88  THR A CA  1 
ATOM   53   C C   A THR A 1 7   ? 16.22168  -30.59389 -19.68372 0.658 9.21849  ? 88  THR A C   1 
ATOM   54   C C   B THR A 1 7   ? 15.77380  -30.53930 -20.15853 0.342 15.64463 ? 88  THR A C   1 
ATOM   55   O O   A THR A 1 7   ? 16.82023  -30.79651 -18.63181 0.658 9.01738  ? 88  THR A O   1 
ATOM   56   O O   B THR A 1 7   ? 14.71932  -30.69226 -20.78162 0.342 14.12741 ? 88  THR A O   1 
ATOM   57   C CB  A THR A 1 7   ? 17.91318  -30.07130 -21.47610 0.658 11.49292 ? 88  THR A CB  1 
ATOM   58   C CB  B THR A 1 7   ? 18.16446  -30.32621 -20.93879 0.342 12.53707 ? 88  THR A CB  1 
ATOM   59   O OG1 A THR A 1 7   ? 18.31468  -29.06838 -22.41463 0.658 10.76003 ? 88  THR A OG1 1 
ATOM   60   O OG1 B THR A 1 7   ? 18.98831  -29.53708 -21.80109 0.342 14.15244 ? 88  THR A OG1 1 
ATOM   61   C CG2 A THR A 1 7   ? 17.54368  -31.34838 -22.23202 0.658 13.08395 ? 88  THR A CG2 1 
ATOM   62   C CG2 B THR A 1 7   ? 17.90835  -31.68126 -21.60050 0.342 12.18664 ? 88  THR A CG2 1 
ATOM   63   N N   A GLY A 1 8   ? 15.10849  -31.24072 -20.01820 0.658 8.68044  ? 89  GLY A N   1 
ATOM   64   N N   B GLY A 1 8   ? 16.02116  -31.19859 -19.03173 0.342 17.00648 ? 89  GLY A N   1 
ATOM   65   C CA  A GLY A 1 8   ? 14.49032  -32.24466 -19.18195 0.658 12.36120 ? 89  GLY A CA  1 
ATOM   66   C CA  B GLY A 1 8   ? 15.12451  -32.26054 -18.60393 0.342 16.34390 ? 89  GLY A CA  1 
ATOM   67   C C   A GLY A 1 8   ? 13.63148  -31.71078 -18.06137 0.658 10.80745 ? 89  GLY A C   1 
ATOM   68   C C   B GLY A 1 8   ? 14.02068  -31.83615 -17.65545 0.342 12.50158 ? 89  GLY A C   1 
ATOM   69   O O   A GLY A 1 8   ? 13.17911  -32.50163 -17.22435 0.658 12.87156 ? 89  GLY A O   1 
ATOM   70   O O   B GLY A 1 8   ? 13.53212  -32.64728 -16.86044 0.342 10.91670 ? 89  GLY A O   1 
ATOM   71   N N   A PHE A 1 9   ? 13.37332  -30.40552 -18.02118 0.658 12.26585 ? 90  PHE A N   1 
ATOM   72   N N   B PHE A 1 9   ? 13.60809  -30.57315 -17.74354 0.342 10.17960 ? 90  PHE A N   1 
ATOM   73   C CA  A PHE A 1 9   ? 12.62375  -29.78567 -16.93988 0.658 11.94892 ? 90  PHE A CA  1 
ATOM   74   C CA  B PHE A 1 9   ? 12.70565  -29.95767 -16.78095 0.342 11.39324 ? 90  PHE A CA  1 
ATOM   75   C C   A PHE A 1 9   ? 11.38421  -29.09649 -17.48055 0.658 12.01624 ? 90  PHE A C   1 
ATOM   76   C C   B PHE A 1 9   ? 11.53236  -29.29361 -17.48917 0.342 11.48241 ? 90  PHE A C   1 
ATOM   77   O O   A PHE A 1 9   ? 11.38325  -28.56565 -18.59535 0.658 11.45122 ? 90  PHE A O   1 
ATOM   78   O O   B PHE A 1 9   ? 11.56402  -29.04644 -18.69653 0.342 13.10479 ? 90  PHE A O   1 
ATOM   79   C CB  A PHE A 1 9   ? 13.48351  -28.75834 -16.17373 0.658 11.80559 ? 90  PHE A CB  1 
ATOM   80   C CB  B PHE A 1 9   ? 13.44986  -28.90910 -15.93673 0.342 12.07640 ? 90  PHE A CB  1 
ATOM   81   C CG  A PHE A 1 9   ? 14.46108  -29.39499 -15.25035 0.658 10.41505 ? 90  PHE A CG  1 
ATOM   82   C CG  B PHE A 1 9   ? 14.33237  -29.50755 -14.89228 0.342 12.26460 ? 90  PHE A CG  1 
ATOM   83   C CD1 A PHE A 1 9   ? 15.61893  -29.95112 -15.75229 0.658 12.17069 ? 90  PHE A CD1 1 
ATOM   84   C CD1 B PHE A 1 9   ? 15.50268  -30.16189 -15.24406 0.342 13.58386 ? 90  PHE A CD1 1 
ATOM   85   C CD2 A PHE A 1 9   ? 14.21354  -29.47937 -13.88862 0.658 12.55722 ? 90  PHE A CD2 1 
ATOM   86   C CD2 B PHE A 1 9   ? 13.98756  -29.43578 -13.55713 0.342 11.96847 ? 90  PHE A CD2 1 
ATOM   87   C CE1 A PHE A 1 9   ? 16.51659  -30.57188 -14.92283 0.658 12.76405 ? 90  PHE A CE1 1 
ATOM   88   C CE1 B PHE A 1 9   ? 16.30438  -30.73088 -14.28622 0.342 11.57746 ? 90  PHE A CE1 1 
ATOM   89   C CE2 A PHE A 1 9   ? 15.11985  -30.10941 -13.04354 0.658 12.53811 ? 90  PHE A CE2 1 
ATOM   90   C CE2 B PHE A 1 9   ? 14.79202  -30.00428 -12.59857 0.342 12.23659 ? 90  PHE A CE2 1 
ATOM   91   C CZ  A PHE A 1 9   ? 16.26623  -30.66105 -13.56729 0.658 14.45290 ? 90  PHE A CZ  1 
ATOM   92   C CZ  B PHE A 1 9   ? 15.94953  -30.65155 -12.96079 0.342 10.22976 ? 90  PHE A CZ  1 
ATOM   93   N N   A GLN A 1 10  ? 10.32386  -29.11714 -16.67600 0.658 12.58424 ? 91  GLN A N   1 
ATOM   94   N N   B GLN A 1 10  ? 10.48597  -29.01058 -16.71258 0.342 13.43017 ? 91  GLN A N   1 
ATOM   95   C CA  A GLN A 1 10  ? 9.14196   -28.31025 -16.93235 0.658 11.99853 ? 91  GLN A CA  1 
ATOM   96   C CA  B GLN A 1 10  ? 9.32838   -28.25071 -17.17027 0.342 13.36684 ? 91  GLN A CA  1 
ATOM   97   C C   A GLN A 1 10  ? 9.27512   -27.01171 -16.15163 0.658 11.63059 ? 91  GLN A C   1 
ATOM   98   C C   B GLN A 1 10  ? 9.25496   -26.97250 -16.34298 0.342 11.46448 ? 91  GLN A C   1 
ATOM   99   O O   A GLN A 1 10  ? 9.45889   -27.02998 -14.93081 0.658 12.71434 ? 91  GLN A O   1 
ATOM   100  O O   B GLN A 1 10  ? 9.44216   -27.00751 -15.12194 0.342 12.37497 ? 91  GLN A O   1 
ATOM   101  C CB  A GLN A 1 10  ? 7.88486   -29.04946 -16.47522 0.658 12.86371 ? 91  GLN A CB  1 
ATOM   102  C CB  B GLN A 1 10  ? 8.05399   -29.09922 -17.04186 0.342 15.58481 ? 91  GLN A CB  1 
ATOM   103  C CG  A GLN A 1 10  ? 6.63043   -28.49370 -17.08746 0.658 21.09514 ? 91  GLN A CG  1 
ATOM   104  C CG  B GLN A 1 10  ? 6.86519   -28.43016 -16.39286 0.342 18.29379 ? 91  GLN A CG  1 
ATOM   105  C CD  A GLN A 1 10  ? 6.54028   -28.82771 -18.55325 0.658 22.83228 ? 91  GLN A CD  1 
ATOM   106  C CD  B GLN A 1 10  ? 5.57164   -29.19259 -16.63113 0.342 15.20812 ? 91  GLN A CD  1 
ATOM   107  O OE1 A GLN A 1 10  ? 7.01468   -29.87498 -18.98469 0.658 26.89057 ? 91  GLN A OE1 1 
ATOM   108  O OE1 B GLN A 1 10  ? 5.55359   -30.21790 -17.31273 0.342 18.74201 ? 91  GLN A OE1 1 
ATOM   109  N NE2 A GLN A 1 10  ? 5.93572   -27.94115 -19.33079 0.658 26.10264 ? 91  GLN A NE2 1 
ATOM   110  N NE2 B GLN A 1 10  ? 4.48547   -28.70001 -16.05610 0.342 12.75566 ? 91  GLN A NE2 1 
ATOM   111  N N   A ILE A 1 11  ? 9.17692   -25.88382 -16.84361 0.658 11.24502 ? 92  ILE A N   1 
ATOM   112  N N   B ILE A 1 11  ? 9.00406   -25.84625 -17.00195 0.342 12.23110 ? 92  ILE A N   1 
ATOM   113  C CA  A ILE A 1 11  ? 9.22653   -24.61156 -16.13797 0.658 11.51366 ? 92  ILE A CA  1 
ATOM   114  C CA  B ILE A 1 11  ? 9.13631   -24.54184 -16.35645 0.342 12.19920 ? 92  ILE A CA  1 
ATOM   115  C C   A ILE A 1 11  ? 7.91756   -24.39083 -15.39125 0.658 10.65956 ? 92  ILE A C   1 
ATOM   116  C C   B ILE A 1 11  ? 7.86097   -24.20027 -15.59168 0.342 10.67689 ? 92  ILE A C   1 
ATOM   117  O O   A ILE A 1 11  ? 6.82161   -24.60171 -15.93694 0.658 11.00480 ? 92  ILE A O   1 
ATOM   118  O O   B ILE A 1 11  ? 6.79919   -24.00319 -16.19286 0.342 10.19769 ? 92  ILE A O   1 
ATOM   119  C CB  A ILE A 1 11  ? 9.51174   -23.45830 -17.10697 0.658 11.60423 ? 92  ILE A CB  1 
ATOM   120  C CB  B ILE A 1 11  ? 9.45820   -23.45378 -17.38703 0.342 12.17870 ? 92  ILE A CB  1 
ATOM   121  C CG1 A ILE A 1 11  ? 10.82741  -23.68027 -17.85269 0.658 10.82537 ? 92  ILE A CG1 1 
ATOM   122  C CG1 B ILE A 1 11  ? 10.51983  -23.93510 -18.38182 0.342 13.96988 ? 92  ILE A CG1 1 
ATOM   123  C CG2 A ILE A 1 11  ? 9.52048   -22.13790 -16.34319 0.658 11.80875 ? 92  ILE A CG2 1 
ATOM   124  C CG2 B ILE A 1 11  ? 9.90230   -22.18867 -16.67162 0.342 16.04308 ? 92  ILE A CG2 1 
ATOM   125  C CD1 A ILE A 1 11  ? 10.93329  -22.82664 -19.08554 0.658 13.12721 ? 92  ILE A CD1 1 
ATOM   126  C CD1 B ILE A 1 11  ? 11.20789  -22.80406 -19.09978 0.342 15.44415 ? 92  ILE A CD1 1 
ATOM   127  N N   A PHE A 1 12  ? 8.02930   -23.96576 -14.13511 0.658 9.90177  ? 93  PHE A N   1 
ATOM   128  N N   B PHE A 1 12  ? 7.97189   -24.10169 -14.26666 0.342 10.66613 ? 93  PHE A N   1 
ATOM   129  C CA  A PHE A 1 12  ? 6.87069   -23.54330 -13.37153 0.658 11.18325 ? 93  PHE A CA  1 
ATOM   130  C CA  B PHE A 1 12  ? 6.83880   -23.71952 -13.43321 0.342 11.19306 ? 93  PHE A CA  1 
ATOM   131  C C   A PHE A 1 12  ? 6.40285   -22.19208 -13.88794 0.658 11.45213 ? 93  PHE A C   1 
ATOM   132  C C   B PHE A 1 12  ? 6.38281   -22.31577 -13.80558 0.342 11.16822 ? 93  PHE A C   1 
ATOM   133  O O   A PHE A 1 12  ? 7.19880   -21.26087 -14.02991 0.658 11.28825 ? 93  PHE A O   1 
ATOM   134  O O   B PHE A 1 12  ? 7.13574   -21.34840 -13.65234 0.342 11.74464 ? 93  PHE A O   1 
ATOM   135  C CB  A PHE A 1 12  ? 7.25946   -23.44003 -11.90107 0.658 12.06039 ? 93  PHE A CB  1 
ATOM   136  C CB  B PHE A 1 12  ? 7.26180   -23.75570 -11.96523 0.342 12.77917 ? 93  PHE A CB  1 
ATOM   137  C CG  A PHE A 1 12  ? 6.09521   -23.19473 -10.99328 0.658 12.85891 ? 93  PHE A CG  1 
ATOM   138  C CG  B PHE A 1 12  ? 6.24687   -23.16056 -11.02198 0.342 12.72866 ? 93  PHE A CG  1 
ATOM   139  C CD1 A PHE A 1 12  ? 5.12750   -24.17492 -10.79108 0.658 14.69095 ? 93  PHE A CD1 1 
ATOM   140  C CD1 B PHE A 1 12  ? 5.16003   -23.91305 -10.61059 0.342 14.72350 ? 93  PHE A CD1 1 
ATOM   141  C CD2 A PHE A 1 12  ? 5.97188   -21.99081 -10.33582 0.658 15.18338 ? 93  PHE A CD2 1 
ATOM   142  C CD2 B PHE A 1 12  ? 6.38167   -21.86950 -10.53537 0.342 13.99213 ? 93  PHE A CD2 1 
ATOM   143  C CE1 A PHE A 1 12  ? 4.05403   -23.93978 -9.94751  0.658 13.91476 ? 93  PHE A CE1 1 
ATOM   144  C CE1 B PHE A 1 12  ? 4.22199   -23.39155 -9.74123  0.342 12.94084 ? 93  PHE A CE1 1 
ATOM   145  C CE2 A PHE A 1 12  ? 4.90487   -21.74673 -9.49630  0.658 14.00550 ? 93  PHE A CE2 1 
ATOM   146  C CE2 B PHE A 1 12  ? 5.43989   -21.34188 -9.66111  0.342 13.66667 ? 93  PHE A CE2 1 
ATOM   147  C CZ  A PHE A 1 12  ? 3.94828   -22.72009 -9.29846  0.658 16.37733 ? 93  PHE A CZ  1 
ATOM   148  C CZ  B PHE A 1 12  ? 4.36071   -22.10923 -9.26653  0.342 13.92818 ? 93  PHE A CZ  1 
ATOM   149  N N   A LEU A 1 13  ? 5.11516   -22.08609 -14.18953 0.658 11.43913 ? 94  LEU A N   1 
ATOM   150  N N   B LEU A 1 13  ? 5.14940   -22.20226 -14.29369 0.342 11.36817 ? 94  LEU A N   1 
ATOM   151  C CA  A LEU A 1 13  ? 4.54886   -20.86407 -14.74424 0.658 11.80516 ? 94  LEU A CA  1 
ATOM   152  C CA  B LEU A 1 13  ? 4.63022   -20.91175 -14.73138 0.342 11.99352 ? 94  LEU A CA  1 
ATOM   153  C C   A LEU A 1 13  ? 4.11325   -19.94282 -13.61237 0.658 13.03001 ? 94  LEU A C   1 
ATOM   154  C C   B LEU A 1 13  ? 4.48119   -19.96963 -13.54200 0.342 11.70740 ? 94  LEU A C   1 
ATOM   155  O O   A LEU A 1 13  ? 3.38195   -20.36370 -12.71188 0.658 13.70974 ? 94  LEU A O   1 
ATOM   156  O O   B LEU A 1 13  ? 4.12759   -20.39140 -12.43841 0.342 13.83669 ? 94  LEU A O   1 
ATOM   157  C CB  A LEU A 1 13  ? 3.35550   -21.22386 -15.62749 0.658 11.81801 ? 94  LEU A CB  1 
ATOM   158  C CB  B LEU A 1 13  ? 3.27358   -21.10687 -15.40145 0.342 12.39667 ? 94  LEU A CB  1 
ATOM   159  C CG  A LEU A 1 13  ? 3.68604   -22.01782 -16.88821 0.658 10.24029 ? 94  LEU A CG  1 
ATOM   160  C CG  B LEU A 1 13  ? 3.34060   -21.51434 -16.87341 0.342 9.30393  ? 94  LEU A CG  1 
ATOM   161  C CD1 A LEU A 1 13  ? 2.43391   -22.58712 -17.51788 0.658 13.66292 ? 94  LEU A CD1 1 
ATOM   162  C CD1 B LEU A 1 13  ? 1.97959   -21.98854 -17.36173 0.342 13.69384 ? 94  LEU A CD1 1 
ATOM   163  C CD2 A LEU A 1 13  ? 4.41442   -21.12032 -17.87297 0.658 15.30617 ? 94  LEU A CD2 1 
ATOM   164  C CD2 B LEU A 1 13  ? 3.88168   -20.39484 -17.75096 0.342 13.08443 ? 94  LEU A CD2 1 
ATOM   165  N N   A SER A 1 14  ? 4.55739   -18.69378 -13.65696 0.658 12.42060 ? 95  SER A N   1 
ATOM   166  N N   B SER A 1 14  ? 4.74648   -18.68898 -13.76621 0.342 12.18825 ? 95  SER A N   1 
ATOM   167  C CA  A SER A 1 14  ? 4.22370   -17.74502 -12.59760 0.658 13.19143 ? 95  SER A CA  1 
ATOM   168  C CA  B SER A 1 14  ? 4.77139   -17.74033 -12.65678 0.342 13.10336 ? 95  SER A CA  1 
ATOM   169  C C   A SER A 1 14  ? 2.71224   -17.62893 -12.41616 0.658 12.38287 ? 95  SER A C   1 
ATOM   170  C C   B SER A 1 14  ? 3.34607   -17.43831 -12.20774 0.342 14.82644 ? 95  SER A C   1 
ATOM   171  O O   A SER A 1 14  ? 2.01412   -17.24346 -13.36280 0.658 12.03416 ? 95  SER A O   1 
ATOM   172  O O   B SER A 1 14  ? 2.54749   -16.92687 -13.00621 0.342 12.33853 ? 95  SER A O   1 
ATOM   173  C CB  A SER A 1 14  ? 4.78524   -16.36040 -12.90059 0.658 11.96702 ? 95  SER A CB  1 
ATOM   174  C CB  B SER A 1 14  ? 5.49973   -16.45638 -13.05870 0.342 14.49841 ? 95  SER A CB  1 
ATOM   175  O OG  A SER A 1 14  ? 4.17845   -15.41680 -12.01982 0.658 13.40743 ? 95  SER A OG  1 
ATOM   176  O OG  B SER A 1 14  ? 5.00798   -15.32686 -12.36178 0.342 15.09673 ? 95  SER A OG  1 
ATOM   177  N N   A PRO A 1 15  ? 2.16881   -17.94479 -11.23501 0.658 12.72184 ? 96  PRO A N   1 
ATOM   178  N N   B PRO A 1 15  ? 2.97828   -17.73859 -10.95929 0.342 13.63336 ? 96  PRO A N   1 
ATOM   179  C CA  A PRO A 1 15  ? 0.73417   -17.71180 -11.01051 0.658 13.52839 ? 96  PRO A CA  1 
ATOM   180  C CA  B PRO A 1 15  ? 1.60991   -17.43658 -10.51663 0.342 13.73624 ? 96  PRO A CA  1 
ATOM   181  C C   A PRO A 1 15  ? 0.38878   -16.24008 -10.93302 0.658 14.25515 ? 96  PRO A C   1 
ATOM   182  C C   B PRO A 1 15  ? 1.34932   -15.95054 -10.41581 0.342 14.23295 ? 96  PRO A C   1 
ATOM   183  O O   A PRO A 1 15  ? -0.74190  -15.85436 -11.25676 0.658 14.78131 ? 96  PRO A O   1 
ATOM   184  O O   B PRO A 1 15  ? 0.20545   -15.51764 -10.59924 0.342 15.78325 ? 96  PRO A O   1 
ATOM   185  C CB  A PRO A 1 15  ? 0.46056   -18.42834 -9.67868  0.658 16.58567 ? 96  PRO A CB  1 
ATOM   186  C CB  B PRO A 1 15  ? 1.52778   -18.11272 -9.13834  0.342 12.07232 ? 96  PRO A CB  1 
ATOM   187  C CG  A PRO A 1 15  ? 1.66584   -19.29949 -9.43790  0.658 22.01250 ? 96  PRO A CG  1 
ATOM   188  C CG  B PRO A 1 15  ? 2.65771   -19.09205 -9.11914  0.342 16.93673 ? 96  PRO A CG  1 
ATOM   189  C CD  A PRO A 1 15  ? 2.81114   -18.60432 -10.08825 0.658 17.38967 ? 96  PRO A CD  1 
ATOM   190  C CD  B PRO A 1 15  ? 3.74222   -18.43173 -9.91342  0.342 14.48348 ? 96  PRO A CD  1 
ATOM   191  N N   A TYR A 1 16  ? 1.33579   -15.40812 -10.50793 0.658 12.97207 ? 97  TYR A N   1 
ATOM   192  N N   B TYR A 1 16  ? 2.38448   -15.16195 -10.12104 0.342 13.82041 ? 97  TYR A N   1 
ATOM   193  C CA  A TYR A 1 16  ? 1.09499   -13.97448 -10.42604 0.658 13.14985 ? 97  TYR A CA  1 
ATOM   194  C CA  B TYR A 1 16  ? 2.23390   -13.71419 -10.03522 0.342 16.38923 ? 97  TYR A CA  1 
ATOM   195  C C   A TYR A 1 16  ? 0.95093   -13.36937 -11.81944 0.658 15.57960 ? 97  TYR A C   1 
ATOM   196  C C   B TYR A 1 16  ? 1.83010   -13.12798 -11.38322 0.342 14.05261 ? 97  TYR A C   1 
ATOM   197  O O   A TYR A 1 16  ? 0.02297   -12.59268 -12.08270 0.658 13.77864 ? 97  TYR A O   1 
ATOM   198  O O   B TYR A 1 16  ? 0.84707   -12.38526 -11.48313 0.342 14.07071 ? 97  TYR A O   1 
ATOM   199  C CB  A TYR A 1 16  ? 2.24241   -13.32486 -9.65390  0.658 16.96682 ? 97  TYR A CB  1 
ATOM   200  C CB  B TYR A 1 16  ? 3.55191   -13.11248 -9.55051  0.342 16.10600 ? 97  TYR A CB  1 
ATOM   201  C CG  A TYR A 1 16  ? 2.07983   -11.84516 -9.46169  0.658 15.65634 ? 97  TYR A CG  1 
ATOM   202  C CG  B TYR A 1 16  ? 3.48273   -11.66190 -9.14335  0.342 19.02022 ? 97  TYR A CG  1 
ATOM   203  C CD1 A TYR A 1 16  ? 1.29271   -11.34502 -8.43282  0.658 18.69217 ? 97  TYR A CD1 1 
ATOM   204  C CD1 B TYR A 1 16  ? 2.46887   -11.19156 -8.31801  0.342 21.90876 ? 97  TYR A CD1 1 
ATOM   205  C CD2 A TYR A 1 16  ? 2.70558   -10.94392 -10.30859 0.658 18.79594 ? 97  TYR A CD2 1 
ATOM   206  C CD2 B TYR A 1 16  ? 4.43681   -10.75833 -9.58855  0.342 21.01292 ? 97  TYR A CD2 1 
ATOM   207  C CE1 A TYR A 1 16  ? 1.13604   -9.98945  -8.25532  0.658 21.35665 ? 97  TYR A CE1 1 
ATOM   208  C CE1 B TYR A 1 16  ? 2.41231   -9.85782  -7.94751  0.342 21.63229 ? 97  TYR A CE1 1 
ATOM   209  C CE2 A TYR A 1 16  ? 2.56021   -9.58681  -10.13320 0.658 21.92159 ? 97  TYR A CE2 1 
ATOM   210  C CE2 B TYR A 1 16  ? 4.38863   -9.42882  -9.22550  0.342 20.88069 ? 97  TYR A CE2 1 
ATOM   211  C CZ  A TYR A 1 16  ? 1.77081   -9.11393  -9.10917  0.658 20.16354 ? 97  TYR A CZ  1 
ATOM   212  C CZ  B TYR A 1 16  ? 3.37667   -8.98294  -8.40660  0.342 22.92771 ? 97  TYR A CZ  1 
ATOM   213  O OH  A TYR A 1 16  ? 1.61160   -7.76121  -8.92987  0.658 24.03175 ? 97  TYR A OH  1 
ATOM   214  O OH  B TYR A 1 16  ? 3.33595   -7.65506  -8.04872  0.342 22.09573 ? 97  TYR A OH  1 
ATOM   215  N N   A TYR A 1 17  ? 1.85711   -13.72966 -12.73407 0.658 14.44067 ? 98  TYR A N   1 
ATOM   216  N N   B TYR A 1 17  ? 2.57550   -13.46938 -12.43703 0.342 13.50432 ? 98  TYR A N   1 
ATOM   217  C CA  A TYR A 1 17  ? 1.73273   -13.27050 -14.11320 0.658 13.10182 ? 98  TYR A CA  1 
ATOM   218  C CA  B TYR A 1 17  ? 2.25660   -12.99631 -13.78165 0.342 10.35967 ? 98  TYR A CA  1 
ATOM   219  C C   A TYR A 1 17  ? 0.49403   -13.86158 -14.76994 0.658 12.18517 ? 98  TYR A C   1 
ATOM   220  C C   B TYR A 1 17  ? 0.92847   -13.56160 -14.26963 0.342 12.30656 ? 98  TYR A C   1 
ATOM   221  O O   A TYR A 1 17  ? -0.21981  -13.16743 -15.49828 0.658 13.41728 ? 98  TYR A O   1 
ATOM   222  O O   B TYR A 1 17  ? 0.17071   -12.86660 -14.95523 0.342 11.25697 ? 98  TYR A O   1 
ATOM   223  C CB  A TYR A 1 17  ? 2.99307   -13.61873 -14.90814 0.658 12.72748 ? 98  TYR A CB  1 
ATOM   224  C CB  B TYR A 1 17  ? 3.39438   -13.38470 -14.72550 0.342 12.54676 ? 98  TYR A CB  1 
ATOM   225  C CG  A TYR A 1 17  ? 3.14333   -12.85957 -16.21536 0.658 13.20959 ? 98  TYR A CG  1 
ATOM   226  C CG  B TYR A 1 17  ? 3.35020   -12.84419 -16.14944 0.342 13.39981 ? 98  TYR A CG  1 
ATOM   227  C CD1 A TYR A 1 17  ? 3.21571   -11.46667 -16.24045 0.658 13.50491 ? 98  TYR A CD1 1 
ATOM   228  C CD1 B TYR A 1 17  ? 3.40929   -11.47960 -16.40702 0.342 13.42885 ? 98  TYR A CD1 1 
ATOM   229  C CD2 A TYR A 1 17  ? 3.21116   -13.53545 -17.42083 0.658 12.21334 ? 98  TYR A CD2 1 
ATOM   230  C CD2 B TYR A 1 17  ? 3.32620   -13.70891 -17.23872 0.342 13.68723 ? 98  TYR A CD2 1 
ATOM   231  C CE1 A TYR A 1 17  ? 3.35935   -10.77487 -17.44005 0.658 12.71020 ? 98  TYR A CE1 1 
ATOM   232  C CE1 B TYR A 1 17  ? 3.40450   -10.99284 -17.71257 0.342 12.09793 ? 98  TYR A CE1 1 
ATOM   233  C CE2 A TYR A 1 17  ? 3.35984   -12.86282 -18.61387 0.658 12.02042 ? 98  TYR A CE2 1 
ATOM   234  C CE2 B TYR A 1 17  ? 3.32299   -13.23285 -18.54451 0.342 11.94716 ? 98  TYR A CE2 1 
ATOM   235  C CZ  A TYR A 1 17  ? 3.42254   -11.48594 -18.62079 0.658 11.97148 ? 98  TYR A CZ  1 
ATOM   236  C CZ  B TYR A 1 17  ? 3.36236   -11.87437 -18.77364 0.342 11.81505 ? 98  TYR A CZ  1 
ATOM   237  O OH  A TYR A 1 17  ? 3.56929   -10.84232 -19.82650 0.658 12.46236 ? 98  TYR A OH  1 
ATOM   238  O OH  B TYR A 1 17  ? 3.36835   -11.39511 -20.06508 0.342 11.84479 ? 98  TYR A OH  1 
ATOM   239  N N   A ALA A 1 18  ? 0.21730   -15.14559 -14.51315 0.658 13.25042 ? 99  ALA A N   1 
ATOM   240  N N   B ALA A 1 18  ? 0.62636   -14.81833 -13.92538 0.342 10.96057 ? 99  ALA A N   1 
ATOM   241  C CA  A ALA A 1 18  ? -0.99583  -15.75903 -15.04515 0.658 14.59789 ? 99  ALA A CA  1 
ATOM   242  C CA  B ALA A 1 18  ? -0.63397  -15.41825 -14.35559 0.342 14.45850 ? 99  ALA A CA  1 
ATOM   243  C C   A ALA A 1 18  ? -2.24249  -15.00583 -14.59568 0.658 13.06308 ? 99  ALA A C   1 
ATOM   244  C C   B ALA A 1 18  ? -1.82610  -14.62352 -13.84404 0.342 16.12940 ? 99  ALA A C   1 
ATOM   245  O O   A ALA A 1 18  ? -3.15990  -14.78379 -15.39320 0.658 16.78417 ? 99  ALA A O   1 
ATOM   246  O O   B ALA A 1 18  ? -2.81961  -14.44937 -14.55853 0.342 15.19985 ? 99  ALA A O   1 
ATOM   247  C CB  A ALA A 1 18  ? -1.07591  -17.22710 -14.62720 0.658 14.28493 ? 99  ALA A CB  1 
ATOM   248  C CB  B ALA A 1 18  ? -0.71381  -16.87045 -13.88682 0.342 13.20780 ? 99  ALA A CB  1 
ATOM   249  N N   A ASN A 1 19  ? -2.28842  -14.60026 -13.32461 0.658 15.75842 ? 100 ASN A N   1 
ATOM   250  N N   B ASN A 1 19  ? -1.72790  -14.09665 -12.62461 0.342 14.30277 ? 100 ASN A N   1 
ATOM   251  C CA  A ASN A 1 19  ? -3.43273  -13.84483 -12.81695 0.658 14.37786 ? 100 ASN A CA  1 
ATOM   252  C CA  B ASN A 1 19  ? -2.80530  -13.31081 -12.03211 0.342 16.79176 ? 100 ASN A CA  1 
ATOM   253  C C   A ASN A 1 19  ? -3.44307  -12.42090 -13.36293 0.658 17.15775 ? 100 ASN A C   1 
ATOM   254  C C   B ASN A 1 19  ? -3.11851  -12.02771 -12.79794 0.342 17.38253 ? 100 ASN A C   1 
ATOM   255  O O   A ASN A 1 19  ? -4.49016  -11.93149 -13.80927 0.658 18.32761 ? 100 ASN A O   1 
ATOM   256  O O   B ASN A 1 19  ? -4.05506  -11.32211 -12.41498 0.342 22.72209 ? 100 ASN A O   1 
ATOM   257  C CB  A ASN A 1 19  ? -3.42063  -13.82603 -11.28943 0.658 20.55333 ? 100 ASN A CB  1 
ATOM   258  C CB  B ASN A 1 19  ? -2.46562  -12.98332 -10.57687 0.342 19.54844 ? 100 ASN A CB  1 
ATOM   259  C CG  A ASN A 1 19  ? -3.78226  -15.16685 -10.68600 0.658 21.69717 ? 100 ASN A CG  1 
ATOM   260  C CG  B ASN A 1 19  ? -2.92814  -14.05866 -9.61652  0.342 21.43785 ? 100 ASN A CG  1 
ATOM   261  O OD1 A ASN A 1 19  ? -4.41668  -16.00257 -11.32977 0.658 28.71767 ? 100 ASN A OD1 1 
ATOM   262  O OD1 B ASN A 1 19  ? -2.14240  -14.59103 -8.83105  0.342 26.46937 ? 100 ASN A OD1 1 
ATOM   263  N ND2 A ASN A 1 19  ? -3.37556  -15.37992 -9.43956  0.658 25.10064 ? 100 ASN A ND2 1 
ATOM   264  N ND2 B ASN A 1 19  ? -4.21243  -14.38661 -9.67720  0.342 25.38831 ? 100 ASN A ND2 1 
ATOM   265  N N   A GLU A 1 20  ? -2.29297  -11.72634 -13.29438 0.658 17.32252 ? 101 GLU A N   1 
ATOM   266  N N   B GLU A 1 20  ? -2.38520  -11.71483 -13.86440 0.342 12.41669 ? 101 GLU A N   1 
ATOM   267  C CA  A GLU A 1 20  ? -2.16803  -10.40804 -13.91877 0.658 17.54678 ? 101 GLU A CA  1 
ATOM   268  C CA  B GLU A 1 20  ? -2.55285  -10.47796 -14.62286 0.342 12.74110 ? 101 GLU A CA  1 
ATOM   269  C C   A GLU A 1 20  ? -2.64222  -10.46160 -15.35551 0.658 13.67053 ? 101 GLU A C   1 
ATOM   270  C C   B GLU A 1 20  ? -3.00258  -10.70605 -16.05681 0.342 12.08385 ? 101 GLU A C   1 
ATOM   271  O O   A GLU A 1 20  ? -3.42530  -9.61435  -15.80092 0.658 15.36444 ? 101 GLU A O   1 
ATOM   272  O O   B GLU A 1 20  ? -3.80252  -9.92492  -16.58468 0.342 11.10980 ? 101 GLU A O   1 
ATOM   273  C CB  A GLU A 1 20  ? -0.71366  -9.92702  -13.91520 0.658 18.53783 ? 101 GLU A CB  1 
ATOM   274  C CB  B GLU A 1 20  ? -1.23394  -9.69429  -14.64221 0.342 16.75339 ? 101 GLU A CB  1 
ATOM   275  C CG  A GLU A 1 20  ? -0.20047  -9.31329  -12.63392 0.658 18.49392 ? 101 GLU A CG  1 
ATOM   276  C CG  B GLU A 1 20  ? -0.44400  -9.77213  -13.34749 0.342 16.78773 ? 101 GLU A CG  1 
ATOM   277  C CD  A GLU A 1 20  ? 1.16156   -8.66747  -12.82596 0.658 17.49666 ? 101 GLU A CD  1 
ATOM   278  C CD  B GLU A 1 20  ? 0.87985   -9.03285  -13.41323 0.342 18.06844 ? 101 GLU A CD  1 
ATOM   279  O OE1 A GLU A 1 20  ? 2.02958   -9.28102  -13.49346 0.658 17.16128 ? 101 GLU A OE1 1 
ATOM   280  O OE1 B GLU A 1 20  ? 1.86512   -9.62625  -13.90556 0.342 15.96913 ? 101 GLU A OE1 1 
ATOM   281  O OE2 A GLU A 1 20  ? 1.37142   -7.54769  -12.31269 0.658 20.65957 ? 101 GLU A OE2 1 
ATOM   282  O OE2 B GLU A 1 20  ? 0.95015   -7.87191  -12.96123 0.342 15.76501 ? 101 GLU A OE2 1 
ATOM   283  N N   A VAL A 1 21  ? -2.16692  -11.46665 -16.09226 0.658 14.52061 ? 102 VAL A N   1 
ATOM   284  N N   B VAL A 1 21  ? -2.49764  -11.76382 -16.69269 0.342 10.89971 ? 102 VAL A N   1 
ATOM   285  C CA  A VAL A 1 21  ? -2.57344  -11.64868 -17.47717 0.658 13.94930 ? 102 VAL A CA  1 
ATOM   286  C CA  B VAL A 1 21  ? -2.81948  -12.04536 -18.08902 0.342 10.78320 ? 102 VAL A CA  1 
ATOM   287  C C   A VAL A 1 21  ? -4.05228  -12.00455 -17.55592 0.658 14.45044 ? 102 VAL A C   1 
ATOM   288  C C   B VAL A 1 21  ? -4.30177  -12.35930 -18.24790 0.342 11.18128 ? 102 VAL A C   1 
ATOM   289  O O   A VAL A 1 21  ? -4.76736  -11.52638 -18.43943 0.658 14.25019 ? 102 VAL A O   1 
ATOM   290  O O   B VAL A 1 21  ? -4.97008  -11.85430 -19.15953 0.342 11.90959 ? 102 VAL A O   1 
ATOM   291  C CB  A VAL A 1 21  ? -1.66655  -12.70365 -18.14365 0.658 11.84692 ? 102 VAL A CB  1 
ATOM   292  C CB  B VAL A 1 21  ? -1.92968  -13.18947 -18.60581 0.342 10.49210 ? 102 VAL A CB  1 
ATOM   293  C CG1 A VAL A 1 21  ? -2.25558  -13.21406 -19.45072 0.658 14.42030 ? 102 VAL A CG1 1 
ATOM   294  C CG1 B VAL A 1 21  ? -2.54228  -13.82469 -19.81512 0.342 16.24725 ? 102 VAL A CG1 1 
ATOM   295  C CG2 A VAL A 1 21  ? -0.25550  -12.14357 -18.35938 0.658 13.78415 ? 102 VAL A CG2 1 
ATOM   296  C CG2 B VAL A 1 21  ? -0.52844  -12.67421 -18.92220 0.342 11.78668 ? 102 VAL A CG2 1 
ATOM   297  N N   A ALA A 1 22  ? -4.53622  -12.83850 -16.63068 0.658 16.83030 ? 103 ALA A N   1 
ATOM   298  N N   B ALA A 1 22  ? -4.83083  -13.21092 -17.36908 0.342 12.05338 ? 103 ALA A N   1 
ATOM   299  C CA  A ALA A 1 22  ? -5.95104  -13.20078 -16.63816 0.658 16.12469 ? 103 ALA A CA  1 
ATOM   300  C CA  B ALA A 1 22  ? -6.24356  -13.56351 -17.43369 0.342 10.91240 ? 103 ALA A CA  1 
ATOM   301  C C   A ALA A 1 22  ? -6.82590  -11.97862 -16.39792 0.658 16.44718 ? 103 ALA A C   1 
ATOM   302  C C   B ALA A 1 22  ? -7.12405  -12.33309 -17.24860 0.342 14.77644 ? 103 ALA A C   1 
ATOM   303  O O   A ALA A 1 22  ? -7.80654  -11.74935 -17.11575 0.658 18.97060 ? 103 ALA A O   1 
ATOM   304  O O   B ALA A 1 22  ? -8.08458  -12.12553 -17.99861 0.342 14.66660 ? 103 ALA A O   1 
ATOM   305  C CB  A ALA A 1 22  ? -6.22466  -14.28124 -15.59098 0.658 17.66160 ? 103 ALA A CB  1 
ATOM   306  C CB  B ALA A 1 22  ? -6.56407  -14.62225 -16.37924 0.342 13.13411 ? 103 ALA A CB  1 
ATOM   307  N N   A ALA A 1 23  ? -6.47117  -11.17004 -15.39895 0.658 16.59982 ? 104 ALA A N   1 
ATOM   308  N N   B ALA A 1 23  ? -6.80557  -11.50025 -16.25250 0.342 13.42709 ? 104 ALA A N   1 
ATOM   309  C CA  A ALA A 1 23  ? -7.20740  -9.93452  -15.15403 0.658 18.54850 ? 104 ALA A CA  1 
ATOM   310  C CA  B ALA A 1 23  ? -7.58985  -10.29293 -16.01505 0.342 17.25584 ? 104 ALA A CA  1 
ATOM   311  C C   A ALA A 1 23  ? -7.09145  -8.98244  -16.33491 0.658 17.89886 ? 104 ALA A C   1 
ATOM   312  C C   B ALA A 1 23  ? -7.46884  -9.32118  -17.18134 0.342 13.61689 ? 104 ALA A C   1 
ATOM   313  O O   A ALA A 1 23  ? -8.05377  -8.28132  -16.67212 0.658 17.72857 ? 104 ALA A O   1 
ATOM   314  O O   B ALA A 1 23  ? -8.43917  -8.64116  -17.53852 0.342 14.12034 ? 104 ALA A O   1 
ATOM   315  C CB  A ALA A 1 23  ? -6.69102  -9.26978  -13.87958 0.658 20.00202 ? 104 ALA A CB  1 
ATOM   316  C CB  B ALA A 1 23  ? -7.13940  -9.63215  -14.71205 0.342 16.64986 ? 104 ALA A CB  1 
ATOM   317  N N   A ALA A 1 24  ? -5.92640  -8.96337  -16.98500 0.658 17.03652 ? 105 ALA A N   1 
ATOM   318  N N   B ALA A 1 24  ? -6.28149  -9.24511  -17.78677 0.342 13.38570 ? 105 ALA A N   1 
ATOM   319  C CA  A ALA A 1 24  ? -5.72200  -8.11270  -18.14930 0.658 16.35569 ? 105 ALA A CA  1 
ATOM   320  C CA  B ALA A 1 24  ? -6.06924  -8.35566  -18.92270 0.342 13.50036 ? 105 ALA A CA  1 
ATOM   321  C C   A ALA A 1 24  ? -6.54311  -8.58478  -19.34283 0.658 14.10513 ? 105 ALA A C   1 
ATOM   322  C C   B ALA A 1 24  ? -6.83254  -8.83276  -20.15070 0.342 12.01125 ? 105 ALA A C   1 
ATOM   323  O O   A ALA A 1 24  ? -7.11456  -7.76242  -20.06822 0.658 16.80142 ? 105 ALA A O   1 
ATOM   324  O O   B ALA A 1 24  ? -7.34339  -8.01655  -20.92657 0.342 13.01122 ? 105 ALA A O   1 
ATOM   325  C CB  A ALA A 1 24  ? -4.23752  -8.08947  -18.50591 0.658 16.35872 ? 105 ALA A CB  1 
ATOM   326  C CB  B ALA A 1 24  ? -4.57625  -8.24539  -19.22363 0.342 11.32491 ? 105 ALA A CB  1 
ATOM   327  N N   A ALA A 1 25  ? -6.62015  -9.90350  -19.55657 0.658 17.50368 ? 106 ALA A N   1 
ATOM   328  N N   B ALA A 1 25  ? -6.91122  -10.14978 -20.35256 0.342 12.47110 ? 106 ALA A N   1 
ATOM   329  C CA  A ALA A 1 25  ? -7.18589  -10.43525 -20.79644 0.658 15.26386 ? 106 ALA A CA  1 
ATOM   330  C CA  B ALA A 1 25  ? -7.80371  -10.67953 -21.37495 0.342 15.45978 ? 106 ALA A CA  1 
ATOM   331  C C   A ALA A 1 25  ? -8.69453  -10.21722 -20.88361 0.658 19.15575 ? 106 ALA A C   1 
ATOM   332  C C   B ALA A 1 25  ? -9.24958  -10.26895 -21.12382 0.342 15.28147 ? 106 ALA A C   1 
ATOM   333  O O   A ALA A 1 25  ? -9.23295  -10.00468 -21.97684 0.658 18.24342 ? 106 ALA A O   1 
ATOM   334  O O   B ALA A 1 25  ? -10.03965 -10.20289 -22.07231 0.342 21.48131 ? 106 ALA A O   1 
ATOM   335  C CB  A ALA A 1 25  ? -6.86065  -11.92257 -20.92852 0.658 17.80114 ? 106 ALA A CB  1 
ATOM   336  C CB  B ALA A 1 25  ? -7.67490  -12.20264 -21.45308 0.342 17.69425 ? 106 ALA A CB  1 
ATOM   337  N N   A LYS A 1 26  ? -9.40119  -10.30483 -19.75756 0.658 19.59620 ? 107 LYS A N   1 
ATOM   338  N N   B LYS A 1 26  ? -9.60434  -9.97215  -19.87135 0.342 21.12617 ? 107 LYS A N   1 
ATOM   339  C CA  A LYS A 1 26  ? -10.84402 -10.08597 -19.79133 0.658 20.04395 ? 107 LYS A CA  1 
ATOM   340  C CA  B LYS A 1 26  ? -10.93990 -9.49759  -19.53373 0.342 20.09321 ? 107 LYS A CA  1 
ATOM   341  C C   A LYS A 1 26  ? -11.22026 -8.63443  -20.07168 0.658 18.87822 ? 107 LYS A C   1 
ATOM   342  C C   B LYS A 1 26  ? -11.09496 -7.98828  -19.66687 0.342 20.37500 ? 107 LYS A C   1 
ATOM   343  O O   A LYS A 1 26  ? -12.39061 -8.36117  -20.36916 0.658 21.51670 ? 107 LYS A O   1 
ATOM   344  O O   B LYS A 1 26  ? -12.22398 -7.51060  -19.82545 0.342 21.84450 ? 107 LYS A O   1 
ATOM   345  C CB  A LYS A 1 26  ? -11.50295 -10.59673 -18.50782 0.658 22.94931 ? 107 LYS A CB  1 
ATOM   346  C CB  B LYS A 1 26  ? -11.32594 -9.92969  -18.11375 0.342 22.64650 ? 107 LYS A CB  1 
ATOM   347  C CG  A LYS A 1 26  ? -11.05172 -9.89422  -17.24337 0.658 24.42436 ? 107 LYS A CG  1 
ATOM   348  C CG  B LYS A 1 26  ? -11.22360 -11.42723 -17.86429 0.342 22.09860 ? 107 LYS A CG  1 
ATOM   349  C CD  A LYS A 1 26  ? -11.63083 -10.58567 -16.01561 0.658 28.65844 ? 107 LYS A CD  1 
ATOM   350  C CD  B LYS A 1 26  ? -11.07518 -11.73704 -16.37974 0.342 26.12844 ? 107 LYS A CD  1 
ATOM   351  C CE  A LYS A 1 26  ? -11.31799 -12.07520 -16.01604 0.658 28.67155 ? 107 LYS A CE  1 
ATOM   352  C CE  B LYS A 1 26  ? -11.41713 -13.19235 -16.07577 0.342 24.37719 ? 107 LYS A CE  1 
ATOM   353  N NZ  A LYS A 1 26  ? -11.78638 -12.75056 -14.77092 0.658 30.57810 ? 107 LYS A NZ  1 
ATOM   354  N NZ  B LYS A 1 26  ? -10.20854 -14.05565 -15.92674 0.342 24.45659 ? 107 LYS A NZ  1 
ATOM   355  N N   A GLN A 1 27  ? -10.26638 -7.70787  -19.99425 0.658 20.39185 ? 108 GLN A N   1 
ATOM   356  N N   B GLN A 1 27  ? -10.00260 -7.22499  -19.59705 0.342 19.44511 ? 108 GLN A N   1 
ATOM   357  C CA  A GLN A 1 27  ? -10.49491 -6.31392  -20.34909 0.658 17.85508 ? 108 GLN A CA  1 
ATOM   358  C CA  B GLN A 1 27  ? -10.07466 -5.78630  -19.82337 0.342 20.72470 ? 108 GLN A CA  1 
ATOM   359  C C   A GLN A 1 27  ? -10.29544 -6.04004  -21.83279 0.658 19.51260 ? 108 GLN A C   1 
ATOM   360  C C   B GLN A 1 27  ? -9.90340  -5.40706  -21.28741 0.342 19.67455 ? 108 GLN A C   1 
ATOM   361  O O   A GLN A 1 27  ? -10.74203 -4.99357  -22.31932 0.658 20.02300 ? 108 GLN A O   1 
ATOM   362  O O   B GLN A 1 27  ? -10.25355 -4.28469  -21.66756 0.342 21.33886 ? 108 GLN A O   1 
ATOM   363  C CB  A GLN A 1 27  ? -9.57174  -5.40189  -19.53476 0.658 21.08704 ? 108 GLN A CB  1 
ATOM   364  C CB  B GLN A 1 27  ? -9.03915  -5.04383  -18.97039 0.342 21.55330 ? 108 GLN A CB  1 
ATOM   365  C CG  A GLN A 1 27  ? -9.80516  -5.46682  -18.03850 0.658 21.34526 ? 108 GLN A CG  1 
ATOM   366  C CG  B GLN A 1 27  ? -9.60248  -3.83740  -18.22633 0.342 26.33223 ? 108 GLN A CG  1 
ATOM   367  C CD  A GLN A 1 27  ? -8.80651  -4.63543  -17.25584 0.658 25.82740 ? 108 GLN A CD  1 
ATOM   368  C CD  B GLN A 1 27  ? -8.92072  -2.53228  -18.60191 0.342 25.50435 ? 108 GLN A CD  1 
ATOM   369  O OE1 A GLN A 1 27  ? -8.29336  -5.07039  -16.22367 0.658 33.41949 ? 108 GLN A OE1 1 
ATOM   370  O OE1 B GLN A 1 27  ? -8.02044  -2.06766  -17.90383 0.342 27.48204 ? 108 GLN A OE1 1 
ATOM   371  N NE2 A GLN A 1 27  ? -8.51550  -3.43880  -17.74999 0.658 27.72998 ? 108 GLN A NE2 1 
ATOM   372  N NE2 B GLN A 1 27  ? -9.36138  -1.92566  -19.70005 0.342 23.56343 ? 108 GLN A NE2 1 
ATOM   373  N N   A ILE A 1 28  ? -9.62798  -6.93790  -22.55443 0.658 20.36218 ? 109 ILE A N   1 
ATOM   374  N N   B ILE A 1 28  ? -9.38527  -6.31256  -22.11178 0.342 21.74807 ? 109 ILE A N   1 
ATOM   375  C CA  A ILE A 1 28  ? -9.42609  -6.76848  -23.98747 0.658 15.95744 ? 109 ILE A CA  1 
ATOM   376  C CA  B ILE A 1 28  ? -9.21710  -6.05423  -23.53751 0.342 18.50649 ? 109 ILE A CA  1 
ATOM   377  C C   A ILE A 1 28  ? -10.72223 -7.11780  -24.70798 0.658 22.08046 ? 109 ILE A C   1 
ATOM   378  C C   B ILE A 1 28  ? -10.56565 -6.21784  -24.22924 0.342 24.04687 ? 109 ILE A C   1 
ATOM   379  O O   A ILE A 1 28  ? -11.28428 -8.20314  -24.51392 0.658 22.68808 ? 109 ILE A O   1 
ATOM   380  O O   B ILE A 1 28  ? -11.25570 -7.22636  -24.03747 0.342 27.01228 ? 109 ILE A O   1 
ATOM   381  C CB  A ILE A 1 28  ? -8.24558  -7.62546  -24.47260 0.658 16.42105 ? 109 ILE A CB  1 
ATOM   382  C CB  B ILE A 1 28  ? -8.15175  -6.99337  -24.12974 0.342 19.47300 ? 109 ILE A CB  1 
ATOM   383  C CG1 A ILE A 1 28  ? -6.93018  -7.05425  -23.94098 0.658 15.81468 ? 109 ILE A CG1 1 
ATOM   384  C CG1 B ILE A 1 28  ? -6.76420  -6.62219  -23.59358 0.342 14.52952 ? 109 ILE A CG1 1 
ATOM   385  C CG2 A ILE A 1 28  ? -8.21155  -7.70297  -25.98372 0.658 16.11658 ? 109 ILE A CG2 1 
ATOM   386  C CG2 B ILE A 1 28  ? -8.16495  -6.93972  -25.64867 0.342 20.83646 ? 109 ILE A CG2 1 
ATOM   387  C CD1 A ILE A 1 28  ? -5.72837  -7.87713  -24.30064 0.658 18.34682 ? 109 ILE A CD1 1 
ATOM   388  C CD1 B ILE A 1 28  ? -5.70338  -7.68393  -23.80712 0.342 15.03334 ? 109 ILE A CD1 1 
ATOM   389  N N   A THR A 1 29  ? -11.20367 -6.19285  -25.54256 0.658 21.10404 ? 110 THR A N   1 
ATOM   390  N N   B THR A 1 29  ? -10.94670 -5.22158  -25.03478 0.342 25.77430 ? 110 THR A N   1 
ATOM   391  C CA  A THR A 1 29  ? -12.56579 -6.30114  -26.05959 0.658 23.01235 ? 110 THR A CA  1 
ATOM   392  C CA  B THR A 1 29  ? -12.27749 -5.21351  -25.63987 0.342 24.08013 ? 110 THR A CA  1 
ATOM   393  C C   A THR A 1 29  ? -12.65628 -7.18085  -27.30179 0.658 27.48217 ? 110 THR A C   1 
ATOM   394  C C   B THR A 1 29  ? -12.41626 -6.29256  -26.70804 0.342 25.33640 ? 110 THR A C   1 
ATOM   395  O O   A THR A 1 29  ? -13.63118 -7.92390  -27.45750 0.658 30.26264 ? 110 THR A O   1 
ATOM   396  O O   B THR A 1 29  ? -13.32388 -7.13098  -26.64477 0.342 26.27203 ? 110 THR A O   1 
ATOM   397  C CB  A THR A 1 29  ? -13.15437 -4.91380  -26.32243 0.658 22.31499 ? 110 THR A CB  1 
ATOM   398  C CB  B THR A 1 29  ? -12.59742 -3.83048  -26.21706 0.342 22.34993 ? 110 THR A CB  1 
ATOM   399  O OG1 A THR A 1 29  ? -12.40249 -4.25406  -27.34983 0.658 28.59266 ? 110 THR A OG1 1 
ATOM   400  O OG1 B THR A 1 29  ? -11.67646 -3.51592  -27.27007 0.342 25.94987 ? 110 THR A OG1 1 
ATOM   401  C CG2 A THR A 1 29  ? -13.12282 -4.07690  -25.05266 0.658 20.22855 ? 110 THR A CG2 1 
ATOM   402  C CG2 B THR A 1 29  ? -12.51564 -2.76927  -25.13990 0.342 19.72588 ? 110 THR A CG2 1 
ATOM   403  N N   A ASP A 1 30  ? -11.67709 -7.11130  -28.19647 0.658 28.60009 ? 111 ASP A N   1 
ATOM   404  N N   B ASP A 1 30  ? -11.53360 -6.28005  -27.70262 0.342 25.22666 ? 111 ASP A N   1 
ATOM   405  C CA  A ASP A 1 30  ? -11.72597 -7.94514  -29.39609 0.658 22.04985 ? 111 ASP A CA  1 
ATOM   406  C CA  B ASP A 1 30  ? -11.63917 -7.20744  -28.82179 0.342 27.49967 ? 111 ASP A CA  1 
ATOM   407  C C   A ASP A 1 30  ? -11.54959 -9.40433  -28.99916 0.658 26.25011 ? 111 ASP A C   1 
ATOM   408  C C   B ASP A 1 30  ? -11.51052 -8.64447  -28.33052 0.342 26.77712 ? 111 ASP A C   1 
ATOM   409  O O   A ASP A 1 30  ? -10.51826 -9.75302  -28.40951 0.658 24.21587 ? 111 ASP A O   1 
ATOM   410  O O   B ASP A 1 30  ? -10.48324 -8.99694  -27.73095 0.342 23.34584 ? 111 ASP A O   1 
ATOM   411  C CB  A ASP A 1 30  ? -10.64845 -7.54047  -30.39529 0.658 24.20787 ? 111 ASP A CB  1 
ATOM   412  C CB  B ASP A 1 30  ? -10.56348 -6.91411  -29.86389 0.342 26.51619 ? 111 ASP A CB  1 
ATOM   413  C CG  A ASP A 1 30  ? -10.70552 -8.36112  -31.67317 0.658 30.24726 ? 111 ASP A CG  1 
ATOM   414  C CG  B ASP A 1 30  ? -10.48892 -7.97964  -30.93792 0.342 26.21090 ? 111 ASP A CG  1 
ATOM   415  O OD1 A ASP A 1 30  ? -11.61910 -8.12536  -32.49336 0.658 33.07066 ? 111 ASP A OD1 1 
ATOM   416  O OD1 B ASP A 1 30  ? -11.55530 -8.40877  -31.42660 0.342 31.65075 ? 111 ASP A OD1 1 
ATOM   417  O OD2 A ASP A 1 30  ? -9.84547  -9.24742  -31.85690 0.658 27.20681 ? 111 ASP A OD2 1 
ATOM   418  O OD2 B ASP A 1 30  ? -9.36525  -8.39003  -31.29552 0.342 27.93496 ? 111 ASP A OD2 1 
ATOM   419  N N   A PRO A 1 31  ? -12.51321 -10.28247 -29.29111 0.658 26.42638 ? 112 PRO A N   1 
ATOM   420  N N   B PRO A 1 31  ? -12.51493 -9.49673  -28.55375 0.342 25.85860 ? 112 PRO A N   1 
ATOM   421  C CA  A PRO A 1 31  ? -12.40826 -11.67345 -28.81450 0.658 28.29003 ? 112 PRO A CA  1 
ATOM   422  C CA  B PRO A 1 31  ? -12.43045 -10.87543 -28.04815 0.342 26.07896 ? 112 PRO A CA  1 
ATOM   423  C C   A PRO A 1 31  ? -11.18799 -12.41668 -29.32787 0.658 25.02058 ? 112 PRO A C   1 
ATOM   424  C C   B PRO A 1 31  ? -11.32743 -11.69144 -28.69498 0.342 25.59858 ? 112 PRO A C   1 
ATOM   425  O O   A PRO A 1 31  ? -10.61488 -13.22836 -28.58986 0.658 28.66930 ? 112 PRO A O   1 
ATOM   426  O O   B PRO A 1 31  ? -10.79404 -12.60423 -28.05195 0.342 24.03580 ? 112 PRO A O   1 
ATOM   427  C CB  A PRO A 1 31  ? -13.71498 -12.31566 -29.30513 0.658 28.71439 ? 112 PRO A CB  1 
ATOM   428  C CB  B PRO A 1 31  ? -13.82145 -11.44794 -28.36534 0.342 27.88934 ? 112 PRO A CB  1 
ATOM   429  C CG  A PRO A 1 31  ? -14.64148 -11.16707 -29.52676 0.658 25.57578 ? 112 PRO A CG  1 
ATOM   430  C CG  B PRO A 1 31  ? -14.69189 -10.23398 -28.52880 0.342 25.80064 ? 112 PRO A CG  1 
ATOM   431  C CD  A PRO A 1 31  ? -13.78477 -10.03102 -29.98802 0.658 27.96211 ? 112 PRO A CD  1 
ATOM   432  C CD  B PRO A 1 31  ? -13.80512 -9.24686  -29.21313 0.342 27.91033 ? 112 PRO A CD  1 
ATOM   433  N N   A THR A 1 32  ? -10.76943 -12.16847 -30.56998 0.658 28.06469 ? 113 THR A N   1 
ATOM   434  N N   B THR A 1 32  ? -10.97619 -11.39834 -29.94844 0.342 27.10636 ? 113 THR A N   1 
ATOM   435  C CA  A THR A 1 32  ? -9.59805  -12.85856 -31.10051 0.658 26.39569 ? 113 THR A CA  1 
ATOM   436  C CA  B THR A 1 32  ? -9.87825  -12.10375 -30.60083 0.342 27.13606 ? 113 THR A CA  1 
ATOM   437  C C   A THR A 1 32  ? -8.32178  -12.38844 -30.41142 0.658 23.75166 ? 113 THR A C   1 
ATOM   438  C C   B THR A 1 32  ? -8.56771  -11.85202 -29.86782 0.342 25.68498 ? 113 THR A C   1 
ATOM   439  O O   A THR A 1 32  ? -7.42651  -13.19577 -30.12511 0.658 23.87433 ? 113 THR A O   1 
ATOM   440  O O   B THR A 1 32  ? -7.88010  -12.79016 -29.44731 0.342 22.84751 ? 113 THR A O   1 
ATOM   441  C CB  A THR A 1 32  ? -9.51552  -12.64666 -32.60994 0.658 31.60320 ? 113 THR A CB  1 
ATOM   442  C CB  B THR A 1 32  ? -9.76988  -11.64983 -32.05760 0.342 28.32000 ? 113 THR A CB  1 
ATOM   443  O OG1 A THR A 1 32  ? -10.73697 -13.08687 -33.21448 0.658 31.16569 ? 113 THR A OG1 1 
ATOM   444  O OG1 B THR A 1 32  ? -10.84236 -10.74822 -32.35892 0.342 30.23114 ? 113 THR A OG1 1 
ATOM   445  C CG2 A THR A 1 32  ? -8.35695  -13.43358 -33.19640 0.658 29.10653 ? 113 THR A CG2 1 
ATOM   446  C CG2 B THR A 1 32  ? -9.83680  -12.84529 -32.99579 0.342 30.88953 ? 113 THR A CG2 1 
ATOM   447  N N   A LEU A 1 33  ? -8.22222  -11.08636 -30.13274 0.658 21.34821 ? 114 LEU A N   1 
ATOM   448  N N   B LEU A 1 33  ? -8.21321  -10.57689 -29.70028 0.342 22.50176 ? 114 LEU A N   1 
ATOM   449  C CA  A LEU A 1 33  ? -7.09037  -10.58779 -29.36066 0.658 20.41474 ? 114 LEU A CA  1 
ATOM   450  C CA  B LEU A 1 33  ? -6.97235  -10.23031 -29.01674 0.342 21.90912 ? 114 LEU A CA  1 
ATOM   451  C C   A LEU A 1 33  ? -7.15721  -11.04883 -27.91306 0.658 21.09147 ? 114 LEU A C   1 
ATOM   452  C C   B LEU A 1 33  ? -6.99254  -10.69923 -27.57006 0.342 21.34620 ? 114 LEU A C   1 
ATOM   453  O O   A LEU A 1 33  ? -6.11561  -11.30812 -27.29827 0.658 19.44364 ? 114 LEU A O   1 
ATOM   454  O O   B LEU A 1 33  ? -5.95720  -11.09801 -27.02367 0.342 19.21654 ? 114 LEU A O   1 
ATOM   455  C CB  A LEU A 1 33  ? -7.03323  -9.06201  -29.43791 0.658 17.46264 ? 114 LEU A CB  1 
ATOM   456  C CB  B LEU A 1 33  ? -6.76033  -8.72135  -29.07761 0.342 21.08890 ? 114 LEU A CB  1 
ATOM   457  C CG  A LEU A 1 33  ? -5.73894  -8.39864  -28.95375 0.658 14.93059 ? 114 LEU A CG  1 
ATOM   458  C CG  B LEU A 1 33  ? -6.23550  -8.16749  -30.39967 0.342 23.18719 ? 114 LEU A CG  1 
ATOM   459  C CD1 A LEU A 1 33  ? -4.55859  -8.73193  -29.86297 0.658 17.24014 ? 114 LEU A CD1 1 
ATOM   460  C CD1 B LEU A 1 33  ? -6.06235  -6.68147  -30.25954 0.342 21.87417 ? 114 LEU A CD1 1 
ATOM   461  C CD2 A LEU A 1 33  ? -5.92174  -6.89413  -28.84162 0.658 17.79736 ? 114 LEU A CD2 1 
ATOM   462  C CD2 B LEU A 1 33  ? -4.92537  -8.83438  -30.79941 0.342 22.34973 ? 114 LEU A CD2 1 
ATOM   463  N N   A SER A 1 34  ? -8.36502  -11.17478 -27.35850 0.658 21.95079 ? 115 SER A N   1 
ATOM   464  N N   B SER A 1 34  ? -8.16341  -10.65196 -26.93067 0.342 20.30125 ? 115 SER A N   1 
ATOM   465  C CA  A SER A 1 34  ? -8.49444  -11.58326 -25.96440 0.658 20.22446 ? 115 SER A CA  1 
ATOM   466  C CA  B SER A 1 34  ? -8.28027  -11.15869 -25.56928 0.342 18.41394 ? 115 SER A CA  1 
ATOM   467  C C   A SER A 1 34  ? -7.96737  -12.99670 -25.74522 0.658 23.45198 ? 115 SER A C   1 
ATOM   468  C C   B SER A 1 34  ? -7.86563  -12.62112 -25.48507 0.342 21.57922 ? 115 SER A C   1 
ATOM   469  O O   A SER A 1 34  ? -7.26015  -13.25375 -24.76520 0.658 20.13360 ? 115 SER A O   1 
ATOM   470  O O   B SER A 1 34  ? -7.31426  -13.05164 -24.46593 0.342 19.28411 ? 115 SER A O   1 
ATOM   471  C CB  A SER A 1 34  ? -9.94922  -11.47308 -25.51069 0.658 22.48979 ? 115 SER A CB  1 
ATOM   472  C CB  B SER A 1 34  ? -9.71528  -10.99223 -25.07672 0.342 23.26715 ? 115 SER A CB  1 
ATOM   473  O OG  A SER A 1 34  ? -10.04858 -11.52840 -24.09510 0.658 21.08754 ? 115 SER A OG  1 
ATOM   474  O OG  B SER A 1 34  ? -10.47364 -12.15749 -25.34634 0.342 26.43284 ? 115 SER A OG  1 
ATOM   475  N N   A SER A 1 35  ? -8.29616  -13.92769 -26.64505 0.658 21.22604 ? 116 SER A N   1 
ATOM   476  N N   B SER A 1 35  ? -8.11466  -13.39389 -26.54668 0.342 20.34226 ? 116 SER A N   1 
ATOM   477  C CA  A SER A 1 35  ? -7.83014  -15.30266 -26.47667 0.658 21.63013 ? 116 SER A CA  1 
ATOM   478  C CA  B SER A 1 35  ? -7.71380  -14.79750 -26.56521 0.342 22.96738 ? 116 SER A CA  1 
ATOM   479  C C   A SER A 1 35  ? -6.32393  -15.40656 -26.68606 0.658 19.58222 ? 116 SER A C   1 
ATOM   480  C C   B SER A 1 35  ? -6.19861  -14.93631 -26.64436 0.342 19.12220 ? 116 SER A C   1 
ATOM   481  O O   A SER A 1 35  ? -5.65121  -16.20773 -26.02516 0.658 17.44505 ? 116 SER A O   1 
ATOM   482  O O   B SER A 1 35  ? -5.59055  -15.64733 -25.83429 0.342 22.85797 ? 116 SER A O   1 
ATOM   483  C CB  A SER A 1 35  ? -8.57517  -16.24300 -27.42331 0.658 25.97460 ? 116 SER A CB  1 
ATOM   484  C CB  B SER A 1 35  ? -8.38154  -15.51816 -27.73543 0.342 25.09802 ? 116 SER A CB  1 
ATOM   485  O OG  A SER A 1 35  ? -8.13374  -16.08287 -28.76007 0.658 27.76920 ? 116 SER A OG  1 
ATOM   486  O OG  B SER A 1 35  ? -9.53059  -14.81706 -28.17425 0.342 28.73804 ? 116 SER A OG  1 
ATOM   487  N N   A LYS A 1 36  ? -5.77518  -14.61181 -27.60533 0.658 20.90379 ? 117 LYS A N   1 
ATOM   488  N N   B LYS A 1 36  ? -5.57438  -14.28541 -27.63442 0.342 20.86824 ? 117 LYS A N   1 
ATOM   489  C CA  A LYS A 1 36  ? -4.32515  -14.55150 -27.73716 0.658 18.96670 ? 117 LYS A CA  1 
ATOM   490  C CA  B LYS A 1 36  ? -4.11534  -14.25806 -27.70367 0.342 20.22628 ? 117 LYS A CA  1 
ATOM   491  C C   A LYS A 1 36  ? -3.69644  -14.03621 -26.44910 0.658 16.23633 ? 117 LYS A C   1 
ATOM   492  C C   B LYS A 1 36  ? -3.52322  -13.77184 -26.39052 0.342 16.91636 ? 117 LYS A C   1 
ATOM   493  O O   A LYS A 1 36  ? -2.69415  -14.58398 -25.97120 0.658 14.90382 ? 117 LYS A O   1 
ATOM   494  O O   B LYS A 1 36  ? -2.56482  -14.36061 -25.87461 0.342 16.06088 ? 117 LYS A O   1 
ATOM   495  C CB  A LYS A 1 36  ? -3.94983  -13.64146 -28.90585 0.658 21.33737 ? 117 LYS A CB  1 
ATOM   496  C CB  B LYS A 1 36  ? -3.64375  -13.34722 -28.84226 0.342 21.66226 ? 117 LYS A CB  1 
ATOM   497  C CG  A LYS A 1 36  ? -4.18781  -14.23406 -30.29025 0.658 22.03143 ? 117 LYS A CG  1 
ATOM   498  C CG  B LYS A 1 36  ? -4.72415  -12.90166 -29.81627 0.342 24.02320 ? 117 LYS A CG  1 
ATOM   499  C CD  A LYS A 1 36  ? -3.73040  -15.67657 -30.38266 0.658 27.84785 ? 117 LYS A CD  1 
ATOM   500  C CD  B LYS A 1 36  ? -5.07715  -13.97567 -30.83280 0.342 25.27519 ? 117 LYS A CD  1 
ATOM   501  C CE  A LYS A 1 36  ? -4.06878  -16.27827 -31.74078 0.658 28.54817 ? 117 LYS A CE  1 
ATOM   502  C CE  B LYS A 1 36  ? -3.83289  -14.65552 -31.38135 0.342 25.53803 ? 117 LYS A CE  1 
ATOM   503  N NZ  A LYS A 1 36  ? -3.52238  -17.66269 -31.88147 0.658 25.86259 ? 117 LYS A NZ  1 
ATOM   504  N NZ  B LYS A 1 36  ? -3.57027  -15.97855 -30.74840 0.342 26.61758 ? 117 LYS A NZ  1 
ATOM   505  N N   A ALA A 1 37  ? -4.29380  -12.99772 -25.85917 0.658 15.69649 ? 118 ALA A N   1 
ATOM   506  N N   B ALA A 1 37  ? -4.08356  -12.69373 -25.83632 0.342 16.20899 ? 118 ALA A N   1 
ATOM   507  C CA  A ALA A 1 37  ? -3.75400  -12.41127 -24.63777 0.658 14.96592 ? 118 ALA A CA  1 
ATOM   508  C CA  B ALA A 1 37  ? -3.65316  -12.22379 -24.52599 0.342 15.25233 ? 118 ALA A CA  1 
ATOM   509  C C   A ALA A 1 37  ? -3.80220  -13.39024 -23.46826 0.658 16.02071 ? 118 ALA A C   1 
ATOM   510  C C   B ALA A 1 37  ? -3.72658  -13.34748 -23.50374 0.342 16.03850 ? 118 ALA A C   1 
ATOM   511  O O   A ALA A 1 37  ? -2.83543  -13.49695 -22.70148 0.658 15.86964 ? 118 ALA A O   1 
ATOM   512  O O   B ALA A 1 37  ? -2.77744  -13.57359 -22.74800 0.342 15.78393 ? 118 ALA A O   1 
ATOM   513  C CB  A ALA A 1 37  ? -4.51173  -11.12881 -24.30254 0.658 16.78359 ? 118 ALA A CB  1 
ATOM   514  C CB  B ALA A 1 37  ? -4.50433  -11.03128 -24.08742 0.342 16.82443 ? 118 ALA A CB  1 
ATOM   515  N N   A ALA A 1 38  ? -4.92771  -14.09681 -23.30009 0.658 15.87479 ? 119 ALA A N   1 
ATOM   516  N N   B ALA A 1 38  ? -4.83969  -14.09034 -23.49830 0.342 16.69940 ? 119 ALA A N   1 
ATOM   517  C CA  A ALA A 1 38  ? -5.04816  -15.05178 -22.20197 0.658 15.81834 ? 119 ALA A CA  1 
ATOM   518  C CA  B ALA A 1 38  ? -5.00021  -15.18954 -22.55273 0.342 14.01909 ? 119 ALA A CA  1 
ATOM   519  C C   A ALA A 1 38  ? -3.95396  -16.10968 -22.26860 0.658 14.93079 ? 119 ALA A C   1 
ATOM   520  C C   B ALA A 1 38  ? -3.91723  -16.24854 -22.71973 0.342 10.38558 ? 119 ALA A C   1 
ATOM   521  O O   A ALA A 1 38  ? -3.42939  -16.53470 -21.23383 0.658 14.18997 ? 119 ALA A O   1 
ATOM   522  O O   B ALA A 1 38  ? -3.48382  -16.84679 -21.73100 0.342 12.08122 ? 119 ALA A O   1 
ATOM   523  C CB  A ALA A 1 38  ? -6.43273  -15.70602 -22.22476 0.658 16.83410 ? 119 ALA A CB  1 
ATOM   524  C CB  B ALA A 1 38  ? -6.39193  -15.81102 -22.69454 0.342 15.89728 ? 119 ALA A CB  1 
ATOM   525  N N   A SER A 1 39  ? -3.59683  -16.53657 -23.48017 0.658 12.62023 ? 120 SER A N   1 
ATOM   526  N N   B SER A 1 39  ? -3.46995  -16.49733 -23.95056 0.342 15.02737 ? 120 SER A N   1 
ATOM   527  C CA  A SER A 1 39  ? -2.60599  -17.59545 -23.66510 0.658 13.79842 ? 120 SER A CA  1 
ATOM   528  C CA  B SER A 1 39  ? -2.45334  -17.52323 -24.15046 0.342 14.15516 ? 120 SER A CA  1 
ATOM   529  C C   A SER A 1 39  ? -1.21188  -17.19233 -23.20522 0.658 12.97502 ? 120 SER A C   1 
ATOM   530  C C   B SER A 1 39  ? -1.09845  -17.13752 -23.56303 0.342 13.04251 ? 120 SER A C   1 
ATOM   531  O O   A SER A 1 39  ? -0.37340  -18.06795 -22.96820 0.658 12.10159 ? 120 SER A O   1 
ATOM   532  O O   B SER A 1 39  ? -0.20355  -17.99071 -23.51144 0.342 12.99475 ? 120 SER A O   1 
ATOM   533  C CB  A SER A 1 39  ? -2.55226  -18.02315 -25.13518 0.658 14.18883 ? 120 SER A CB  1 
ATOM   534  C CB  B SER A 1 39  ? -2.32411  -17.88095 -25.63384 0.342 16.85689 ? 120 SER A CB  1 
ATOM   535  O OG  A SER A 1 39  ? -1.79651  -17.11261 -25.93091 0.658 15.44386 ? 120 SER A OG  1 
ATOM   536  O OG  B SER A 1 39  ? -1.71014  -16.83800 -26.37426 0.342 16.12117 ? 120 SER A OG  1 
ATOM   537  N N   . VAL A 1 40  ? -0.93821  -15.89275 -23.09833 1.000 13.69459 ? 121 VAL A N   1 
ATOM   538  C CA  . VAL A 1 40  ? 0.34258   -15.43849 -22.56861 1.000 12.60725 ? 121 VAL A CA  1 
ATOM   539  C C   . VAL A 1 40  ? 0.60907   -15.99388 -21.17760 1.000 13.46508 ? 121 VAL A C   1 
ATOM   540  O O   . VAL A 1 40  ? 1.77048   -16.15707 -20.78790 1.000 13.80292 ? 121 VAL A O   1 
ATOM   541  C CB  . VAL A 1 40  ? 0.39891   -13.90062 -22.63476 1.000 14.07562 ? 121 VAL A CB  1 
ATOM   542  C CG1 . VAL A 1 40  ? 1.60881   -13.34852 -21.90126 1.000 13.81602 ? 121 VAL A CG1 1 
ATOM   543  C CG2 . VAL A 1 40  ? 0.41220   -13.45923 -24.08112 1.000 15.74007 ? 121 VAL A CG2 1 
ATOM   544  N N   . ALA A 1 41  ? -0.43826  -16.33765 -20.42482 1.000 14.31015 ? 122 ALA A N   1 
ATOM   545  C CA  . ALA A 1 41  ? -0.24119  -16.93866 -19.11033 1.000 13.87695 ? 122 ALA A CA  1 
ATOM   546  C C   . ALA A 1 41  ? 0.44920   -18.28907 -19.18283 1.000 13.89195 ? 122 ALA A C   1 
ATOM   547  O O   . ALA A 1 41  ? 0.93867   -18.77192 -18.16067 1.000 13.81596 ? 122 ALA A O   1 
ATOM   548  C CB  . ALA A 1 41  ? -1.58591  -17.08603 -18.39673 1.000 16.66536 ? 122 ALA A CB  1 
ATOM   549  N N   . ASN A 1 42  ? 0.47914   -18.91322 -20.34771 1.000 12.00546 ? 123 ASN A N   1 
ATOM   550  C CA  . ASN A 1 42  ? 1.15153   -20.18953 -20.53320 1.000 12.84006 ? 123 ASN A CA  1 
ATOM   551  C C   . ASN A 1 42  ? 2.60592   -20.03247 -20.94674 1.000 12.24718 ? 123 ASN A C   1 
ATOM   552  O O   . ASN A 1 42  ? 3.27164   -21.04353 -21.18399 1.000 13.40205 ? 123 ASN A O   1 
ATOM   553  C CB  . ASN A 1 42  ? 0.42703   -21.01458 -21.60053 1.000 14.58580 ? 123 ASN A CB  1 
ATOM   554  C CG  . ASN A 1 42  ? -1.02317  -21.28155 -21.24888 1.000 18.37714 ? 123 ASN A CG  1 
ATOM   555  O OD1 . ASN A 1 42  ? -1.34683  -21.56312 -20.10312 1.000 21.14531 ? 123 ASN A OD1 1 
ATOM   556  N ND2 . ASN A 1 42  ? -1.90117  -21.19237 -22.24069 1.000 20.21548 ? 123 ASN A ND2 1 
ATOM   557  N N   . ILE A 1 43  ? 3.09971   -18.80767 -21.06583 1.000 12.63556 ? 124 ILE A N   1 
ATOM   558  C CA  . ILE A 1 43  ? 4.46827   -18.55111 -21.50593 1.000 11.53799 ? 124 ILE A CA  1 
ATOM   559  C C   . ILE A 1 43  ? 5.31871   -18.29583 -20.26756 1.000 11.35976 ? 124 ILE A C   1 
ATOM   560  O O   . ILE A 1 43  ? 4.99628   -17.38742 -19.49117 1.000 12.56718 ? 124 ILE A O   1 
ATOM   561  C CB  . ILE A 1 43  ? 4.53774   -17.36376 -22.47442 1.000 12.01497 ? 124 ILE A CB  1 
ATOM   562  C CG1 . ILE A 1 43  ? 3.59297   -17.60912 -23.65705 1.000 13.20975 ? 124 ILE A CG1 1 
ATOM   563  C CG2 . ILE A 1 43  ? 5.97922   -17.14598 -22.93149 1.000 12.51225 ? 124 ILE A CG2 1 
ATOM   564  C CD1 . ILE A 1 43  ? 3.42996   -16.40615 -24.56480 1.000 15.19003 ? 124 ILE A CD1 1 
ATOM   565  N N   . PRO A 1 44  ? 6.39719   -19.04050 -20.05689 1.000 11.24708 ? 125 PRO A N   1 
ATOM   566  C CA  . PRO A 1 44  ? 7.15928   -18.89956 -18.81081 1.000 11.52268 ? 125 PRO A CA  1 
ATOM   567  C C   . PRO A 1 44  ? 7.91520   -17.58170 -18.73337 1.000 11.04410 ? 125 PRO A C   1 
ATOM   568  O O   . PRO A 1 44  ? 8.53047   -17.12894 -19.70530 1.000 11.33913 ? 125 PRO A O   1 
ATOM   569  C CB  . PRO A 1 44  ? 8.12782   -20.08406 -18.85597 1.000 13.36466 ? 125 PRO A CB  1 
ATOM   570  C CG  . PRO A 1 44  ? 8.22093   -20.45931 -20.28615 1.000 14.59712 ? 125 PRO A CG  1 
ATOM   571  C CD  . PRO A 1 44  ? 6.90241   -20.12701 -20.90728 1.000 12.49381 ? 125 PRO A CD  1 
ATOM   572  N N   . THR A 1 45  ? 7.85260   -16.97017 -17.55550 1.000 12.15983 ? 126 THR A N   1 
ATOM   573  C CA  . THR A 1 45  ? 8.53503   -15.72506 -17.24226 1.000 10.68434 ? 126 THR A CA  1 
ATOM   574  C C   . THR A 1 45  ? 9.31467   -15.88585 -15.94269 1.000 10.40208 ? 126 THR A C   1 
ATOM   575  O O   . THR A 1 45  ? 9.15392   -16.86552 -15.20370 1.000 10.59295 ? 126 THR A O   1 
ATOM   576  C CB  . THR A 1 45  ? 7.53440   -14.57211 -17.07364 1.000 11.87306 ? 126 THR A CB  1 
ATOM   577  O OG1 . THR A 1 45  ? 6.59794   -14.88324 -16.02937 1.000 12.11630 ? 126 THR A OG1 1 
ATOM   578  C CG2 . THR A 1 45  ? 6.79767   -14.26758 -18.37988 1.000 13.07650 ? 126 THR A CG2 1 
ATOM   579  N N   . PHE A 1 46  ? 10.17432  -14.91070 -15.66469 1.000 10.00327 ? 127 PHE A N   1 
ATOM   580  C CA  . PHE A 1 46  ? 10.91064  -14.87165 -14.41314 1.000 9.91776  ? 127 PHE A CA  1 
ATOM   581  C C   . PHE A 1 46  ? 10.13407  -14.08380 -13.36499 1.000 9.57957  ? 127 PHE A C   1 
ATOM   582  O O   . PHE A 1 46  ? 9.51055   -13.05978 -13.67608 1.000 10.73447 ? 127 PHE A O   1 
ATOM   583  C CB  . PHE A 1 46  ? 12.27999  -14.22731 -14.63384 1.000 9.52594  ? 127 PHE A CB  1 
ATOM   584  C CG  . PHE A 1 46  ? 13.31363  -15.18022 -15.15199 1.000 8.51278  ? 127 PHE A CG  1 
ATOM   585  C CD1 . PHE A 1 46  ? 13.19211  -15.74441 -16.41240 1.000 10.08171 ? 127 PHE A CD1 1 
ATOM   586  C CD2 . PHE A 1 46  ? 14.39467  -15.53743 -14.37575 1.000 10.07085 ? 127 PHE A CD2 1 
ATOM   587  C CE1 . PHE A 1 46  ? 14.13746  -16.64609 -16.87559 1.000 10.14306 ? 127 PHE A CE1 1 
ATOM   588  C CE2 . PHE A 1 46  ? 15.33380  -16.43281 -14.84393 1.000 9.47142  ? 127 PHE A CE2 1 
ATOM   589  C CZ  . PHE A 1 46  ? 15.20162  -16.98381 -16.08130 1.000 10.22441 ? 127 PHE A CZ  1 
ATOM   590  N N   . THR A 1 47  ? 10.19871  -14.55366 -12.12491 1.000 10.50927 ? 128 THR A N   1 
ATOM   591  C CA  A THR A 1 47  ? 9.61413   -13.88791 -10.95791 0.501 10.98472 ? 128 THR A CA  1 
ATOM   592  C CA  B THR A 1 47  ? 9.60271   -13.83822 -11.01394 0.499 10.89303 ? 128 THR A CA  1 
ATOM   593  C C   . THR A 1 47  ? 10.66509  -12.98620 -10.33858 1.000 9.82586  ? 128 THR A C   1 
ATOM   594  O O   . THR A 1 47  ? 11.73427  -13.47523 -9.96936  1.000 11.37514 ? 128 THR A O   1 
ATOM   595  C CB  A THR A 1 47  ? 9.29058   -14.93535 -9.88996  0.501 13.02255 ? 128 THR A CB  1 
ATOM   596  C CB  B THR A 1 47  ? 8.95043   -14.81531 -10.03974 0.499 12.36478 ? 128 THR A CB  1 
ATOM   597  O OG1 A THR A 1 47  ? 8.19146   -15.74109 -10.30843 0.501 10.99376 ? 128 THR A OG1 1 
ATOM   598  O OG1 B THR A 1 47  ? 7.89508   -15.50338 -10.72614 0.499 13.69966 ? 128 THR A OG1 1 
ATOM   599  C CG2 A THR A 1 47  ? 8.96337   -14.27373 -8.53519  0.501 10.71410 ? 128 THR A CG2 1 
ATOM   600  C CG2 B THR A 1 47  ? 8.37199   -14.06314 -8.84217  0.499 13.57954 ? 128 THR A CG2 1 
ATOM   601  N N   . TRP A 1 48  ? 10.36323  -11.70406 -10.18588 1.000 9.60054  ? 129 TRP A N   1 
ATOM   602  C CA  . TRP A 1 48  ? 11.34494  -10.76357 -9.66145  1.000 10.57495 ? 129 TRP A CA  1 
ATOM   603  C C   . TRP A 1 48  ? 11.23353  -10.66430 -8.14578  1.000 9.81525  ? 129 TRP A C   1 
ATOM   604  O O   . TRP A 1 48  ? 10.20294  -10.23007 -7.60975  1.000 11.61644 ? 129 TRP A O   1 
ATOM   605  C CB  . TRP A 1 48  ? 11.17458  -9.39356  -10.30888 1.000 10.19313 ? 129 TRP A CB  1 
ATOM   606  C CG  . TRP A 1 48  ? 11.56576  -9.36552  -11.76055 1.000 9.87694  ? 129 TRP A CG  1 
ATOM   607  C CD1 . TRP A 1 48  ? 11.03542  -10.10710 -12.77578 1.000 10.74740 ? 129 TRP A CD1 1 
ATOM   608  C CD2 . TRP A 1 48  ? 12.57340  -8.54697  -12.34660 1.000 9.67938  ? 129 TRP A CD2 1 
ATOM   609  N NE1 . TRP A 1 48  ? 11.66136  -9.80095  -13.96576 1.000 9.70875  ? 129 TRP A NE1 1 
ATOM   610  C CE2 . TRP A 1 48  ? 12.60568  -8.83850  -13.72602 1.000 9.22075  ? 129 TRP A CE2 1 
ATOM   611  C CE3 . TRP A 1 48  ? 13.45105  -7.59013  -11.84023 1.000 11.55832 ? 129 TRP A CE3 1 
ATOM   612  C CZ2 . TRP A 1 48  ? 13.49858  -8.21114  -14.59847 1.000 10.06228 ? 129 TRP A CZ2 1 
ATOM   613  C CZ3 . TRP A 1 48  ? 14.32762  -6.97767  -12.69798 1.000 10.64485 ? 129 TRP A CZ3 1 
ATOM   614  C CH2 . TRP A 1 48  ? 14.34701  -7.27968  -14.06031 1.000 10.81558 ? 129 TRP A CH2 1 
ATOM   615  N N   . LEU A 1 49  ? 12.30180  -11.03321 -7.45535  1.000 9.87619  ? 130 LEU A N   1 
ATOM   616  C CA  . LEU A 1 49  ? 12.35302  -10.86697 -6.00405  1.000 10.89305 ? 130 LEU A CA  1 
ATOM   617  C C   . LEU A 1 49  ? 12.92176  -9.48273  -5.71460  1.000 11.05269 ? 130 LEU A C   1 
ATOM   618  O O   . LEU A 1 49  ? 14.07365  -9.29506  -5.31552  1.000 11.72162 ? 130 LEU A O   1 
ATOM   619  C CB  . LEU A 1 49  ? 13.14601  -12.00036 -5.36545  1.000 11.66340 ? 130 LEU A CB  1 
ATOM   620  C CG  . LEU A 1 49  ? 12.66411  -13.41593 -5.72295  1.000 11.09473 ? 130 LEU A CG  1 
ATOM   621  C CD1 . LEU A 1 49  ? 13.53370  -14.45988 -5.03293  1.000 13.01917 ? 130 LEU A CD1 1 
ATOM   622  C CD2 . LEU A 1 49  ? 11.21148  -13.61713 -5.35470  1.000 13.69130 ? 130 LEU A CD2 1 
ATOM   623  N N   . ASP A 1 50  ? 12.08514  -8.48356  -5.96926  1.000 11.25444 ? 131 ASP A N   1 
ATOM   624  C CA  A ASP A 1 50  ? 12.51198  -7.09385  -5.89175  0.574 11.48850 ? 131 ASP A CA  1 
ATOM   625  C CA  B ASP A 1 50  ? 12.54345  -7.10490  -5.88360  0.426 11.52005 ? 131 ASP A CA  1 
ATOM   626  C C   . ASP A 1 50  ? 12.40895  -6.51125  -4.49100  1.000 12.26647 ? 131 ASP A C   1 
ATOM   627  O O   . ASP A 1 50  ? 12.72293  -5.32874  -4.30596  1.000 13.50877 ? 131 ASP A O   1 
ATOM   628  C CB  A ASP A 1 50  ? 11.72431  -6.22869  -6.87808  0.574 14.16078 ? 131 ASP A CB  1 
ATOM   629  C CB  B ASP A 1 50  ? 11.87608  -6.21234  -6.94105  0.426 13.95779 ? 131 ASP A CB  1 
ATOM   630  C CG  A ASP A 1 50  ? 10.25145  -6.16405  -6.54424  0.574 12.33499 ? 131 ASP A CG  1 
ATOM   631  C CG  B ASP A 1 50  ? 10.37543  -6.39952  -7.01398  0.426 16.46659 ? 131 ASP A CG  1 
ATOM   632  O OD1 A ASP A 1 50  ? 9.60507   -7.22308  -6.54440  0.574 12.90635 ? 131 ASP A OD1 1 
ATOM   633  O OD1 B ASP A 1 50  ? 9.76137   -6.75094  -5.98762  0.426 13.14625 ? 131 ASP A OD1 1 
ATOM   634  O OD2 A ASP A 1 50  ? 9.74163   -5.05536  -6.28105  0.574 18.56873 ? 131 ASP A OD2 1 
ATOM   635  O OD2 B ASP A 1 50  ? 9.80871   -6.15877  -8.10291  0.426 23.81813 ? 131 ASP A OD2 1 
ATOM   636  N N   . SER A 1 51  ? 11.98382  -7.29849  -3.51190  1.000 12.86457 ? 132 SER A N   1 
ATOM   637  C CA  . SER A 1 51  ? 11.95296  -6.86473  -2.12483  1.000 12.40432 ? 132 SER A CA  1 
ATOM   638  C C   . SER A 1 51  ? 11.89242  -8.10941  -1.24835  1.000 11.67040 ? 132 SER A C   1 
ATOM   639  O O   . SER A 1 51  ? 11.57907  -9.20716  -1.72138  1.000 12.33412 ? 132 SER A O   1 
ATOM   640  C CB  . SER A 1 51  ? 10.74807  -5.96502  -1.84584  1.000 15.20840 ? 132 SER A CB  1 
ATOM   641  O OG  . SER A 1 51  ? 9.56877   -6.73917  -1.81774  1.000 18.66085 ? 132 SER A OG  1 
ATOM   642  N N   . VAL A 1 52  ? 12.22744  -7.93640  0.03884   1.000 11.68958 ? 133 VAL A N   1 
ATOM   643  C CA  A VAL A 1 52  ? 12.08949  -9.02030  1.01246   0.560 12.36987 ? 133 VAL A CA  1 
ATOM   644  C CA  B VAL A 1 52  ? 12.09546  -9.05035  0.97435   0.440 12.33553 ? 133 VAL A CA  1 
ATOM   645  C C   . VAL A 1 52  ? 10.64818  -9.50215  1.08196   1.000 11.76706 ? 133 VAL A C   1 
ATOM   646  O O   . VAL A 1 52  ? 10.38151  -10.67740 1.35750   1.000 12.72122 ? 133 VAL A O   1 
ATOM   647  C CB  A VAL A 1 52  ? 12.60532  -8.54823  2.38932   0.560 11.98645 ? 133 VAL A CB  1 
ATOM   648  C CB  B VAL A 1 52  ? 12.71099  -8.72858  2.35212   0.440 12.31513 ? 133 VAL A CB  1 
ATOM   649  C CG1 A VAL A 1 52  ? 12.12484  -9.46132  3.50787   0.560 12.90682 ? 133 VAL A CG1 1 
ATOM   650  C CG1 B VAL A 1 52  ? 14.21776  -8.55095  2.24104   0.440 15.28319 ? 133 VAL A CG1 1 
ATOM   651  C CG2 A VAL A 1 52  ? 14.12412  -8.47356  2.39139   0.560 15.20285 ? 133 VAL A CG2 1 
ATOM   652  C CG2 B VAL A 1 52  ? 12.07454  -7.49986  2.94151   0.440 14.37157 ? 133 VAL A CG2 1 
ATOM   653  N N   . ALA A 1 53  ? 9.69561   -8.60026  0.84174   1.000 12.27734 ? 134 ALA A N   1 
ATOM   654  C CA  . ALA A 1 53  ? 8.29282   -8.98052  0.88728   1.000 14.61619 ? 134 ALA A CA  1 
ATOM   655  C C   . ALA A 1 53  ? 7.94682   -10.03220 -0.15468  1.000 15.68680 ? 134 ALA A C   1 
ATOM   656  O O   . ALA A 1 53  ? 6.92946   -10.71707 -0.00217  1.000 19.18179 ? 134 ALA A O   1 
ATOM   657  C CB  . ALA A 1 53  ? 7.40202   -7.75182  0.70134   1.000 16.90332 ? 134 ALA A CB  1 
ATOM   658  N N   . LYS A 1 54  ? 8.75464   -10.17007 -1.21371  1.000 12.99297 ? 135 LYS A N   1 
ATOM   659  C CA  . LYS A 1 54  ? 8.50900   -11.19374 -2.22518  1.000 14.28049 ? 135 LYS A CA  1 
ATOM   660  C C   . LYS A 1 54  ? 9.02873   -12.57034 -1.82692  1.000 11.70596 ? 135 LYS A C   1 
ATOM   661  O O   . LYS A 1 54  ? 8.70460   -13.54864 -2.51041  1.000 13.53697 ? 135 LYS A O   1 
ATOM   662  C CB  . LYS A 1 54  ? 9.16791   -10.81039 -3.55853  1.000 15.20260 ? 135 LYS A CB  1 
ATOM   663  C CG  . LYS A 1 54  ? 8.66433   -9.53072  -4.17365  1.000 16.96709 ? 135 LYS A CG  1 
ATOM   664  C CD  . LYS A 1 54  ? 7.20262   -9.62955  -4.55376  1.000 23.72325 ? 135 LYS A CD  1 
ATOM   665  C CE  . LYS A 1 54  ? 6.71003   -8.32453  -5.16092  1.000 26.97618 ? 135 LYS A CE  1 
ATOM   666  N NZ  . LYS A 1 54  ? 7.01330   -8.20657  -6.60982  1.000 23.06165 ? 135 LYS A NZ  1 
ATOM   667  N N   . ILE A 1 55  ? 9.83824   -12.68802 -0.77558  1.000 12.10543 ? 136 ILE A N   1 
ATOM   668  C CA  . ILE A 1 55  ? 10.44603  -13.98413 -0.45553  1.000 10.84563 ? 136 ILE A CA  1 
ATOM   669  C C   . ILE A 1 55  ? 9.42165   -15.04579 -0.08123  1.000 12.00320 ? 136 ILE A C   1 
ATOM   670  O O   . ILE A 1 55  ? 9.57720   -16.20403 -0.50562  1.000 11.89466 ? 136 ILE A O   1 
ATOM   671  C CB  . ILE A 1 55  ? 11.58372  -13.81662 0.55548   1.000 11.23029 ? 136 ILE A CB  1 
ATOM   672  C CG1 . ILE A 1 55  ? 12.67664  -12.91730 -0.03419  1.000 10.69087 ? 136 ILE A CG1 1 
ATOM   673  C CG2 . ILE A 1 55  ? 12.15457  -15.17350 0.95854   1.000 12.94341 ? 136 ILE A CG2 1 
ATOM   674  C CD1 . ILE A 1 55  ? 13.73157  -12.49824 0.96553   1.000 13.05481 ? 136 ILE A CD1 1 
ATOM   675  N N   . PRO A 1 56  ? 8.37520   -14.75167 0.69673   1.000 12.55269 ? 137 PRO A N   1 
ATOM   676  C CA  . PRO A 1 56  ? 7.36495   -15.79104 0.94198   1.000 13.59116 ? 137 PRO A CA  1 
ATOM   677  C C   . PRO A 1 56  ? 6.72339   -16.29692 -0.33422  1.000 13.27914 ? 137 PRO A C   1 
ATOM   678  O O   . PRO A 1 56  ? 6.36389   -17.47644 -0.40557  1.000 12.87384 ? 137 PRO A O   1 
ATOM   679  C CB  . PRO A 1 56  ? 6.36070   -15.09525 1.86880   1.000 15.49326 ? 137 PRO A CB  1 
ATOM   680  C CG  . PRO A 1 56  ? 7.17738   -14.05898 2.57970   1.000 14.37384 ? 137 PRO A CG  1 
ATOM   681  C CD  . PRO A 1 56  ? 8.16363   -13.56746 1.55421   1.000 14.24321 ? 137 PRO A CD  1 
ATOM   682  N N   . ASP A 1 57  ? 6.59297   -15.45047 -1.35531  1.000 13.18076 ? 138 ASP A N   1 
ATOM   683  C CA  A ASP A 1 57  ? 6.08013   -15.90288 -2.65169  0.617 12.80203 ? 138 ASP A CA  1 
ATOM   684  C CA  B ASP A 1 57  ? 6.05323   -15.94661 -2.61095  0.383 12.88760 ? 138 ASP A CA  1 
ATOM   685  C C   . ASP A 1 57  ? 6.99223   -16.95283 -3.26527  1.000 12.49659 ? 138 ASP A C   1 
ATOM   686  O O   . ASP A 1 57  ? 6.52241   -17.96170 -3.80711  1.000 12.46240 ? 138 ASP A O   1 
ATOM   687  C CB  A ASP A 1 57  ? 5.98206   -14.72941 -3.62463  0.617 14.51753 ? 138 ASP A CB  1 
ATOM   688  C CB  B ASP A 1 57  ? 5.67287   -14.78882 -3.52417  0.383 14.28903 ? 138 ASP A CB  1 
ATOM   689  C CG  A ASP A 1 57  ? 4.92900   -13.73516 -3.24000  0.617 19.01646 ? 138 ASP A CG  1 
ATOM   690  C CG  B ASP A 1 57  ? 4.41945   -14.08888 -3.04924  0.383 20.21990 ? 138 ASP A CG  1 
ATOM   691  O OD1 A ASP A 1 57  ? 4.04115   -14.08120 -2.43578  0.617 20.72106 ? 138 ASP A OD1 1 
ATOM   692  O OD1 B ASP A 1 57  ? 3.36820   -14.75426 -2.95718  0.383 17.40581 ? 138 ASP A OD1 1 
ATOM   693  O OD2 A ASP A 1 57  ? 4.98914   -12.60898 -3.76811  0.617 16.91345 ? 138 ASP A OD2 1 
ATOM   694  O OD2 B ASP A 1 57  ? 4.49212   -12.88596 -2.73138  0.383 23.55587 ? 138 ASP A OD2 1 
ATOM   695  N N   . LEU A 1 58  ? 8.31103   -16.71621 -3.20635  1.000 12.33539 ? 139 LEU A N   1 
ATOM   696  C CA  . LEU A 1 58  ? 9.25749   -17.72315 -3.67286  1.000 11.44928 ? 139 LEU A CA  1 
ATOM   697  C C   . LEU A 1 58  ? 8.98625   -19.05105 -2.99234  1.000 10.70644 ? 139 LEU A C   1 
ATOM   698  O O   . LEU A 1 58  ? 8.92505   -20.09999 -3.64364  1.000 11.52192 ? 139 LEU A O   1 
ATOM   699  C CB  . LEU A 1 58  ? 10.69375  -17.27968 -3.37814  1.000 13.03446 ? 139 LEU A CB  1 
ATOM   700  C CG  . LEU A 1 58  ? 11.74121  -18.38206 -3.55453  1.000 12.28592 ? 139 LEU A CG  1 
ATOM   701  C CD1 . LEU A 1 58  ? 11.80967  -18.82948 -4.99715  1.000 14.43966 ? 139 LEU A CD1 1 
ATOM   702  C CD2 . LEU A 1 58  ? 13.10999  -17.90677 -3.08162  1.000 14.24760 ? 139 LEU A CD2 1 
ATOM   703  N N   . GLY A 1 59  ? 8.81714   -19.01938 -1.66543  1.000 11.12558 ? 140 GLY A N   1 
ATOM   704  C CA  . GLY A 1 59  ? 8.53639   -20.24610 -0.93942  1.000 11.94075 ? 140 GLY A CA  1 
ATOM   705  C C   . GLY A 1 59  ? 7.31298   -20.96349 -1.47058  1.000 10.45158 ? 140 GLY A C   1 
ATOM   706  O O   . GLY A 1 59  ? 7.32921   -22.18094 -1.65966  1.000 11.42226 ? 140 GLY A O   1 
ATOM   707  N N   . THR A 1 60  ? 6.24174   -20.21848 -1.74737  1.000 10.78942 ? 141 THR A N   1 
ATOM   708  C CA  . THR A 1 60  ? 5.05149   -20.88171 -2.27155  1.000 11.00083 ? 141 THR A CA  1 
ATOM   709  C C   . THR A 1 60  ? 5.28257   -21.43617 -3.66681  1.000 10.99403 ? 141 THR A C   1 
ATOM   710  O O   . THR A 1 60  ? 4.75259   -22.49705 -4.00888  1.000 10.98856 ? 141 THR A O   1 
ATOM   711  C CB  . THR A 1 60  ? 3.80214   -19.99042 -2.25332  1.000 11.69366 ? 141 THR A CB  1 
ATOM   712  O OG1 . THR A 1 60  ? 3.88763   -18.93309 -3.21614  1.000 13.43494 ? 141 THR A OG1 1 
ATOM   713  C CG2 . THR A 1 60  ? 3.52391   -19.45359 -0.87749  1.000 12.40321 ? 141 THR A CG2 1 
ATOM   714  N N   . TYR A 1 61  ? 6.06227   -20.73525 -4.49494  1.000 10.33458 ? 142 TYR A N   1 
ATOM   715  C CA  A TYR A 1 61  ? 6.29077   -21.23262 -5.84482  0.632 11.02396 ? 142 TYR A CA  1 
ATOM   716  C CA  B TYR A 1 61  ? 6.31847   -21.22030 -5.84877  0.368 11.03063 ? 142 TYR A CA  1 
ATOM   717  C C   . TYR A 1 61  ? 7.11669   -22.51241 -5.82267  1.000 10.69402 ? 142 TYR A C   1 
ATOM   718  O O   . TYR A 1 61  ? 6.83906   -23.44656 -6.58675  1.000 10.61591 ? 142 TYR A O   1 
ATOM   719  C CB  A TYR A 1 61  ? 6.93621   -20.15904 -6.72774  0.632 12.73325 ? 142 TYR A CB  1 
ATOM   720  C CB  B TYR A 1 61  ? 7.08074   -20.17547 -6.66560  0.368 12.36453 ? 142 TYR A CB  1 
ATOM   721  C CG  A TYR A 1 61  ? 6.09397   -18.90704 -6.94342  0.632 12.40639 ? 142 TYR A CG  1 
ATOM   722  C CG  B TYR A 1 61  ? 6.46046   -18.79872 -6.69828  0.368 13.34966 ? 142 TYR A CG  1 
ATOM   723  C CD1 A TYR A 1 61  ? 4.77219   -18.83254 -6.50713  0.632 14.12086 ? 142 TYR A CD1 1 
ATOM   724  C CD1 B TYR A 1 61  ? 5.08411   -18.62220 -6.58705  0.368 13.71150 ? 142 TYR A CD1 1 
ATOM   725  C CD2 A TYR A 1 61  ? 6.62906   -17.78979 -7.57972  0.632 12.55472 ? 142 TYR A CD2 1 
ATOM   726  C CD2 B TYR A 1 61  ? 7.25118   -17.66971 -6.85871  0.368 13.74011 ? 142 TYR A CD2 1 
ATOM   727  C CE1 A TYR A 1 61  ? 4.01534   -17.67538 -6.69538  0.632 15.75451 ? 142 TYR A CE1 1 
ATOM   728  C CE1 B TYR A 1 61  ? 4.51900   -17.35611 -6.61856  0.368 13.55769 ? 142 TYR A CE1 1 
ATOM   729  C CE2 A TYR A 1 61  ? 5.88223   -16.63898 -7.76607  0.632 16.40724 ? 142 TYR A CE2 1 
ATOM   730  C CE2 B TYR A 1 61  ? 6.69495   -16.40942 -6.89233  0.368 13.05776 ? 142 TYR A CE2 1 
ATOM   731  C CZ  A TYR A 1 61  ? 4.57839   -16.58762 -7.32849  0.632 14.44287 ? 142 TYR A CZ  1 
ATOM   732  C CZ  B TYR A 1 61  ? 5.33212   -16.25459 -6.77328  0.368 12.86591 ? 142 TYR A CZ  1 
ATOM   733  O OH  A TYR A 1 61  ? 3.85293   -15.42681 -7.52897  0.632 17.78853 ? 142 TYR A OH  1 
ATOM   734  O OH  B TYR A 1 61  ? 4.77029   -14.99573 -6.80624  0.368 16.63844 ? 142 TYR A OH  1 
ATOM   735  N N   . LEU A 1 62  ? 8.11975   -22.58151 -4.95153  1.000 10.29986 ? 143 LEU A N   1 
ATOM   736  C CA  . LEU A 1 62  ? 8.91217   -23.80001 -4.83937  1.000 10.61749 ? 143 LEU A CA  1 
ATOM   737  C C   . LEU A 1 62  ? 8.05151   -24.97010 -4.38915  1.000 10.43736 ? 143 LEU A C   1 
ATOM   738  O O   . LEU A 1 62  ? 8.12925   -26.06123 -4.95224  1.000 10.56038 ? 143 LEU A O   1 
ATOM   739  C CB  . LEU A 1 62  ? 10.06334  -23.58846 -3.85911  1.000 10.41983 ? 143 LEU A CB  1 
ATOM   740  C CG  . LEU A 1 62  ? 11.11716  -22.56325 -4.26952  1.000 10.93141 ? 143 LEU A CG  1 
ATOM   741  C CD1 . LEU A 1 62  ? 11.97922  -22.20365 -3.06134  1.000 13.16590 ? 143 LEU A CD1 1 
ATOM   742  C CD2 . LEU A 1 62  ? 11.97068  -23.06328 -5.42799  1.000 13.95769 ? 143 LEU A CD2 1 
ATOM   743  N N   . ALA A 1 63  ? 7.22656   -24.75657 -3.36366  1.000 10.37398 ? 144 ALA A N   1 
ATOM   744  C CA  . ALA A 1 63  ? 6.38721   -25.83819 -2.85413  1.000 10.58943 ? 144 ALA A CA  1 
ATOM   745  C C   . ALA A 1 63  ? 5.33384   -26.25639 -3.87399  1.000 11.84456 ? 144 ALA A C   1 
ATOM   746  O O   . ALA A 1 63  ? 5.03847   -27.45277 -4.01316  1.000 11.54966 ? 144 ALA A O   1 
ATOM   747  C CB  . ALA A 1 63  ? 5.72759   -25.42516 -1.53872  1.000 12.73124 ? 144 ALA A CB  1 
ATOM   748  N N   . SER A 1 64  ? 4.75854   -25.29323 -4.59614  1.000 11.14186 ? 145 SER A N   1 
ATOM   749  C CA  . SER A 1 64  ? 3.78821   -25.62859 -5.63018  1.000 10.57751 ? 145 SER A CA  1 
ATOM   750  C C   . SER A 1 64  ? 4.44744   -26.38884 -6.76661  1.000 11.18353 ? 145 SER A C   1 
ATOM   751  O O   . SER A 1 64  ? 3.89348   -27.38112 -7.26374  1.000 11.52152 ? 145 SER A O   1 
ATOM   752  C CB  . SER A 1 64  ? 3.14821   -24.35901 -6.18332  1.000 11.65282 ? 145 SER A CB  1 
ATOM   753  O OG  . SER A 1 64  ? 2.42273   -23.66005 -5.18488  1.000 12.79121 ? 145 SER A OG  1 
ATOM   754  N N   . ALA A 1 65  ? 5.63607   -25.93853 -7.18377  1.000 11.01959 ? 146 ALA A N   1 
ATOM   755  C CA  . ALA A 1 65  ? 6.36082   -26.63614 -8.23269  1.000 10.01040 ? 146 ALA A CA  1 
ATOM   756  C C   . ALA A 1 65  ? 6.67993   -28.06198 -7.81078  1.000 11.36757 ? 146 ALA A C   1 
ATOM   757  O O   . ALA A 1 65  ? 6.51215   -28.99830 -8.60003  1.000 11.57875 ? 146 ALA A O   1 
ATOM   758  C CB  . ALA A 1 65  ? 7.62799   -25.85272 -8.58742  1.000 11.70343 ? 146 ALA A CB  1 
ATOM   759  N N   . SER A 1 66  ? 7.11911   -28.25083 -6.56480  1.000 10.70215 ? 147 SER A N   1 
ATOM   760  C CA  . SER A 1 66  ? 7.41892   -29.59290 -6.08154  1.000 12.21711 ? 147 SER A CA  1 
ATOM   761  C C   . SER A 1 66  ? 6.20307   -30.50441 -6.21146  1.000 11.59850 ? 147 SER A C   1 
ATOM   762  O O   . SER A 1 66  ? 6.29412   -31.62106 -6.73488  1.000 12.49564 ? 147 SER A O   1 
ATOM   763  C CB  . SER A 1 66  ? 7.87658   -29.51591 -4.62905  1.000 11.98267 ? 147 SER A CB  1 
ATOM   764  O OG  . SER A 1 66  ? 8.20244   -30.80113 -4.13437  1.000 14.28528 ? 147 SER A OG  1 
ATOM   765  N N   . ALA A 1 67  ? 5.03984   -30.02832 -5.77450  1.000 11.91302 ? 148 ALA A N   1 
ATOM   766  C CA  . ALA A 1 67  ? 3.82535   -30.84082 -5.85939  1.000 11.26064 ? 148 ALA A CA  1 
ATOM   767  C C   . ALA A 1 67  ? 3.41358   -31.07806 -7.30801  1.000 11.29876 ? 148 ALA A C   1 
ATOM   768  O O   . ALA A 1 67  ? 2.95590   -32.17572 -7.65849  1.000 12.46071 ? 148 ALA A O   1 
ATOM   769  C CB  . ALA A 1 67  ? 2.70058   -30.18017 -5.06559  1.000 13.16250 ? 148 ALA A CB  1 
ATOM   770  N N   A LEU A 1 68  ? 3.52659   -30.05364 -8.15671  0.651 12.02441 ? 149 LEU A N   1 
ATOM   771  N N   B LEU A 1 68  ? 3.58053   -30.08192 -8.17493  0.349 11.97939 ? 149 LEU A N   1 
ATOM   772  C CA  A LEU A 1 68  ? 3.09302   -30.19472 -9.54217  0.651 12.21411 ? 149 LEU A CA  1 
ATOM   773  C CA  B LEU A 1 68  ? 3.33530   -30.33295 -9.58937  0.349 12.96585 ? 149 LEU A CA  1 
ATOM   774  C C   A LEU A 1 68  ? 3.94861   -31.21031 -10.27970 0.651 11.66497 ? 149 LEU A C   1 
ATOM   775  C C   B LEU A 1 68  ? 4.26302   -31.42690 -10.11317 0.349 12.40952 ? 149 LEU A C   1 
ATOM   776  O O   A LEU A 1 68  ? 3.43845   -31.98091 -11.10602 0.651 12.08141 ? 149 LEU A O   1 
ATOM   777  O O   B LEU A 1 68  ? 3.82000   -32.34159 -10.81891 0.349 11.78814 ? 149 LEU A O   1 
ATOM   778  C CB  A LEU A 1 68  ? 3.15568   -28.85142 -10.26003 0.651 11.65004 ? 149 LEU A CB  1 
ATOM   779  C CB  B LEU A 1 68  ? 3.45370   -29.03681 -10.39880 0.349 13.06103 ? 149 LEU A CB  1 
ATOM   780  C CG  A LEU A 1 68  ? 2.73219   -28.91028 -11.72774 0.651 12.93494 ? 149 LEU A CG  1 
ATOM   781  C CG  B LEU A 1 68  ? 2.46509   -27.90223 -10.07903 0.349 12.50500 ? 149 LEU A CG  1 
ATOM   782  C CD1 A LEU A 1 68  ? 1.30178   -29.41798 -11.85355 0.651 16.37528 ? 149 LEU A CD1 1 
ATOM   783  C CD1 B LEU A 1 68  ? 2.77867   -26.64404 -10.88223 0.349 13.34791 ? 149 LEU A CD1 1 
ATOM   784  C CD2 A LEU A 1 68  ? 2.89742   -27.56312 -12.39650 0.651 14.23274 ? 149 LEU A CD2 1 
ATOM   785  C CD2 B LEU A 1 68  ? 1.01430   -28.33125 -10.29425 0.349 17.66470 ? 149 LEU A CD2 1 
ATOM   786  N N   A GLY A 1 69  ? 5.25156   -31.22593 -9.99658  0.651 11.83323 ? 150 GLY A N   1 
ATOM   787  N N   B GLY A 1 69  ? 5.54041   -31.38658 -9.72743  0.349 11.63317 ? 150 GLY A N   1 
ATOM   788  C CA  A GLY A 1 69  ? 6.11927   -32.21793 -10.60546 0.651 11.49104 ? 150 GLY A CA  1 
ATOM   789  C CA  B GLY A 1 69  ? 6.47212   -32.40935 -10.17733 0.349 9.63277  ? 150 GLY A CA  1 
ATOM   790  C C   A GLY A 1 69  ? 5.71594   -33.63008 -10.23522 0.651 12.15159 ? 150 GLY A C   1 
ATOM   791  C C   B GLY A 1 69  ? 6.14868   -33.78751 -9.62853  0.349 11.90006 ? 150 GLY A C   1 
ATOM   792  O O   A GLY A 1 69  ? 5.66467   -34.51142 -11.09140 0.651 12.57857 ? 150 GLY A O   1 
ATOM   793  O O   B GLY A 1 69  ? 6.30782   -34.79570 -10.32503 0.349 12.44705 ? 150 GLY A O   1 
ATOM   794  N N   A LYS A 1 70  ? 5.40281   -33.85712 -8.95803  0.651 10.70509 ? 151 LYS A N   1 
ATOM   795  N N   B LYS A 1 70  ? 5.69094   -33.85076 -8.37435  0.349 12.09875 ? 151 LYS A N   1 
ATOM   796  C CA  A LYS A 1 70  ? 4.97813   -35.18689 -8.53310  0.651 12.55104 ? 151 LYS A CA  1 
ATOM   797  C CA  B LYS A 1 70  ? 5.35433   -35.13294 -7.76195  0.349 15.80737 ? 151 LYS A CA  1 
ATOM   798  C C   A LYS A 1 70  ? 3.65237   -35.57375 -9.17581  0.651 13.24839 ? 151 LYS A C   1 
ATOM   799  C C   B LYS A 1 70  ? 4.13701   -35.76359 -8.43326  0.349 13.75663 ? 151 LYS A C   1 
ATOM   800  O O   A LYS A 1 70  ? 3.43589   -36.74501 -9.50631  0.651 15.63850 ? 151 LYS A O   1 
ATOM   801  O O   B LYS A 1 70  ? 4.11323   -36.97593 -8.67900  0.349 14.36333 ? 151 LYS A O   1 
ATOM   802  C CB  A LYS A 1 70  ? 4.88121   -35.23995 -7.00647  0.651 14.95373 ? 151 LYS A CB  1 
ATOM   803  C CB  B LYS A 1 70  ? 5.10262   -34.93543 -6.26458  0.349 16.65324 ? 151 LYS A CB  1 
ATOM   804  C CG  A LYS A 1 70  ? 6.22264   -35.12908 -6.27551  0.651 15.86754 ? 151 LYS A CG  1 
ATOM   805  C CG  B LYS A 1 70  ? 6.25253   -35.33976 -5.34031  0.349 22.12880 ? 151 LYS A CG  1 
ATOM   806  C CD  A LYS A 1 70  ? 6.02683   -35.15916 -4.76148  0.651 21.95950 ? 151 LYS A CD  1 
ATOM   807  C CD  B LYS A 1 70  ? 7.42052   -34.36807 -5.41158  0.349 25.63288 ? 151 LYS A CD  1 
ATOM   808  C CE  A LYS A 1 70  ? 7.33568   -34.99348 -4.00621  0.651 21.05148 ? 151 LYS A CE  1 
ATOM   809  C CE  B LYS A 1 70  ? 8.72166   -35.09063 -5.72761  0.349 23.43175 ? 151 LYS A CE  1 
ATOM   810  N NZ  A LYS A 1 70  ? 7.87005   -33.60835 -4.08039  0.651 23.10063 ? 151 LYS A NZ  1 
ATOM   811  N NZ  B LYS A 1 70  ? 8.75956   -35.59050 -7.12746  0.349 25.64242 ? 151 LYS A NZ  1 
ATOM   812  N N   A SER A 1 71  ? 2.75335   -34.60297 -9.36523  0.651 11.46623 ? 152 SER A N   1 
ATOM   813  N N   B SER A 1 71  ? 3.12222   -34.95818 -8.75205  0.349 12.94697 ? 152 SER A N   1 
ATOM   814  C CA  A SER A 1 71  ? 1.43999   -34.88670 -9.93584  0.651 13.08829 ? 152 SER A CA  1 
ATOM   815  C CA  B SER A 1 71  ? 1.89429   -35.50125 -9.32309  0.349 16.56210 ? 152 SER A CA  1 
ATOM   816  C C   A SER A 1 71  ? 1.51815   -35.17826 -11.42788 0.651 12.82429 ? 152 SER A C   1 
ATOM   817  C C   B SER A 1 71  ? 2.04469   -35.88473 -10.79072 0.349 14.74181 ? 152 SER A C   1 
ATOM   818  O O   A SER A 1 71  ? 0.63623   -35.85644 -11.96863 0.651 17.78102 ? 152 SER A O   1 
ATOM   819  O O   B SER A 1 71  ? 1.38919   -36.83095 -11.24441 0.349 16.00465 ? 152 SER A O   1 
ATOM   820  C CB  A SER A 1 71  ? 0.50756   -33.69361 -9.70083  0.651 14.81789 ? 152 SER A CB  1 
ATOM   821  C CB  B SER A 1 71  ? 0.75433   -34.49424 -9.17875  0.349 17.17861 ? 152 SER A CB  1 
ATOM   822  O OG  A SER A 1 71  ? 0.23045   -33.49463 -8.32282  0.651 15.21172 ? 152 SER A OG  1 
ATOM   823  O OG  B SER A 1 71  ? 1.14853   -33.19893 -9.58739  0.349 22.85717 ? 152 SER A OG  1 
ATOM   824  N N   A THR A 1 72  ? 2.53760   -34.66141 -12.11550 0.651 12.78175 ? 153 THR A N   1 
ATOM   825  N N   B THR A 1 72  ? 2.87934   -35.16764 -11.54749 0.349 13.92042 ? 153 THR A N   1 
ATOM   826  C CA  A THR A 1 72  ? 2.63694   -34.78890 -13.56324 0.651 13.51448 ? 153 THR A CA  1 
ATOM   827  C CA  B THR A 1 72  ? 3.00106   -35.38400 -12.98395 0.349 12.62816 ? 153 THR A CA  1 
ATOM   828  C C   A THR A 1 72  ? 3.80654   -35.64743 -14.02881 0.651 13.33207 ? 153 THR A C   1 
ATOM   829  C C   B THR A 1 72  ? 4.21624   -36.21285 -13.36213 0.349 11.59089 ? 153 THR A C   1 
ATOM   830  O O   A THR A 1 72  ? 4.00569   -35.78371 -15.24381 0.651 16.04384 ? 153 THR A O   1 
ATOM   831  O O   B THR A 1 72  ? 4.35246   -36.58861 -14.53117 0.349 14.22395 ? 153 THR A O   1 
ATOM   832  C CB  A THR A 1 72  ? 2.69590   -33.40153 -14.21863 0.651 14.75430 ? 153 THR A CB  1 
ATOM   833  C CB  B THR A 1 72  ? 3.08022   -34.04568 -13.72646 0.349 16.47733 ? 153 THR A CB  1 
ATOM   834  O OG1 A THR A 1 72  ? 3.85859   -32.69210 -13.76274 0.651 14.78919 ? 153 THR A OG1 1 
ATOM   835  O OG1 B THR A 1 72  ? 4.22545   -33.31817 -13.27244 0.349 12.57156 ? 153 THR A OG1 1 
ATOM   836  C CG2 A THR A 1 72  ? 1.45593   -32.59725 -13.87157 0.651 16.17523 ? 153 THR A CG2 1 
ATOM   837  C CG2 B THR A 1 72  ? 1.83383   -33.22174 -13.46800 0.349 16.52660 ? 153 THR A CG2 1 
ATOM   838  N N   A GLY A 1 73  ? 4.56834   -36.23833 -13.11407 0.651 15.35833 ? 154 GLY A N   1 
ATOM   839  N N   B GLY A 1 73  ? 5.09209   -36.51295 -12.40853 0.349 13.75817 ? 154 GLY A N   1 
ATOM   840  C CA  A GLY A 1 73  ? 5.74179   -37.00811 -13.49608 0.651 17.04375 ? 154 GLY A CA  1 
ATOM   841  C CA  B GLY A 1 73  ? 6.35051   -37.14393 -12.73715 0.349 14.34566 ? 154 GLY A CA  1 
ATOM   842  C C   A GLY A 1 73  ? 6.84935   -36.19082 -14.12496 0.651 16.66532 ? 154 GLY A C   1 
ATOM   843  C C   B GLY A 1 73  ? 7.31078   -36.29485 -13.53641 0.349 15.98110 ? 154 GLY A C   1 
ATOM   844  O O   A GLY A 1 73  ? 7.50403   -36.65997 -15.06511 0.651 21.97582 ? 154 GLY A O   1 
ATOM   845  O O   B GLY A 1 73  ? 8.25829   -36.84506 -14.10709 0.349 16.25584 ? 154 GLY A O   1 
ATOM   846  N N   . THR A 1 74  ? 7.08694   -34.98232 -13.62474 1.000 16.06045 ? 155 THR A N   1 
ATOM   847  C CA  . THR A 1 74  ? 8.06374   -34.08860 -14.23050 1.000 14.23071 ? 155 THR A CA  1 
ATOM   848  C C   . THR A 1 74  ? 8.99000   -33.53377 -13.15257 1.000 14.20987 ? 155 THR A C   1 
ATOM   849  O O   . THR A 1 74  ? 8.68521   -33.56233 -11.95667 1.000 16.60535 ? 155 THR A O   1 
ATOM   850  C CB  . THR A 1 74  ? 7.39180   -32.91493 -14.95167 1.000 17.39006 ? 155 THR A CB  1 
ATOM   851  O OG1 . THR A 1 74  ? 6.55035   -32.20749 -14.03761 1.000 16.59371 ? 155 THR A OG1 1 
ATOM   852  C CG2 . THR A 1 74  ? 6.54879   -33.39865 -16.12983 1.000 19.29744 ? 155 THR A CG2 1 
ATOM   853  N N   . LYS A 1 75  ? 10.14731  -33.04986 -13.58870 1.000 13.53669 ? 156 LYS A N   1 
ATOM   854  C CA  . LYS A 1 75  ? 11.02378  -32.23707 -12.75835 1.000 14.38781 ? 156 LYS A CA  1 
ATOM   855  C C   . LYS A 1 75  ? 10.76513  -30.77477 -13.08173 1.000 13.34442 ? 156 LYS A C   1 
ATOM   856  O O   . LYS A 1 75  ? 10.75329  -30.39098 -14.25347 1.000 14.27925 ? 156 LYS A O   1 
ATOM   857  C CB  . LYS A 1 75  ? 12.49034  -32.58896 -12.99720 1.000 13.82376 ? 156 LYS A CB  1 
ATOM   858  C CG  . LYS A 1 75  ? 12.82757  -34.03448 -12.69015 1.000 17.33308 ? 156 LYS A CG  1 
ATOM   859  C CD  . LYS A 1 75  ? 14.18034  -34.41487 -13.24115 1.000 25.69369 ? 156 LYS A CD  1 
ATOM   860  C CE  . LYS A 1 75  ? 14.67118  -35.69650 -12.57866 1.000 32.80734 ? 156 LYS A CE  1 
ATOM   861  N NZ  . LYS A 1 75  ? 16.15577  -35.74414 -12.44595 1.000 42.39581 ? 156 LYS A NZ  1 
ATOM   862  N N   . GLN A 1 76  ? 10.50803  -29.97359 -12.05401 1.000 11.33351 ? 157 GLN A N   1 
ATOM   863  C CA  . GLN A 1 76  ? 10.10300  -28.59154 -12.24961 1.000 10.76666 ? 157 GLN A CA  1 
ATOM   864  C C   . GLN A 1 76  ? 11.24515  -27.61689 -11.99970 1.000 10.23866 ? 157 GLN A C   1 
ATOM   865  O O   . GLN A 1 76  ? 12.14902  -27.87739 -11.20812 1.000 10.59554 ? 157 GLN A O   1 
ATOM   866  C CB  . GLN A 1 76  ? 8.94539   -28.26268 -11.31306 1.000 11.68387 ? 157 GLN A CB  1 
ATOM   867  C CG  . GLN A 1 76  ? 7.73081   -29.15003 -11.54654 1.000 12.58412 ? 157 GLN A CG  1 
ATOM   868  C CD  . GLN A 1 76  ? 6.80414   -28.58252 -12.58256 1.000 13.36978 ? 157 GLN A CD  1 
ATOM   869  O OE1 . GLN A 1 76  ? 6.56543   -27.37744 -12.61841 1.000 16.63673 ? 157 GLN A OE1 1 
ATOM   870  N NE2 . GLN A 1 76  ? 6.25827   -29.45064 -13.43843 1.000 16.34443 ? 157 GLN A NE2 1 
ATOM   871  N N   A LEU A 1 77  ? 11.15807  -26.46251 -12.65266 0.612 10.35614 ? 158 LEU A N   1 
ATOM   872  N N   B LEU A 1 77  ? 11.16049  -26.46796 -12.67031 0.388 10.40651 ? 158 LEU A N   1 
ATOM   873  C CA  A LEU A 1 77  ? 12.19523  -25.44112 -12.61505 0.612 9.55112  ? 158 LEU A CA  1 
ATOM   874  C CA  B LEU A 1 77  ? 12.18010  -25.42751 -12.64898 0.388 9.57002  ? 158 LEU A CA  1 
ATOM   875  C C   A LEU A 1 77  ? 11.53220  -24.09241 -12.38826 0.612 10.76103 ? 158 LEU A C   1 
ATOM   876  C C   B LEU A 1 77  ? 11.49736  -24.09893 -12.36719 0.388 10.75068 ? 158 LEU A C   1 
ATOM   877  O O   A LEU A 1 77  ? 10.61791  -23.71503 -13.12828 0.612 10.21518 ? 158 LEU A O   1 
ATOM   878  O O   B LEU A 1 77  ? 10.53651  -23.73631 -13.05242 0.388 10.18413 ? 158 LEU A O   1 
ATOM   879  C CB  A LEU A 1 77  ? 12.98190  -25.45451 -13.92745 0.612 10.55296 ? 158 LEU A CB  1 
ATOM   880  C CB  B LEU A 1 77  ? 12.90132  -25.38252 -14.00277 0.388 10.82174 ? 158 LEU A CB  1 
ATOM   881  C CG  A LEU A 1 77  ? 14.19114  -24.52839 -14.08637 0.612 9.61417  ? 158 LEU A CG  1 
ATOM   882  C CG  B LEU A 1 77  ? 14.17102  -24.54268 -14.20251 0.388 9.76071  ? 158 LEU A CG  1 
ATOM   883  C CD1 A LEU A 1 77  ? 15.14474  -25.12768 -15.11701 0.612 9.50107  ? 158 LEU A CD1 1 
ATOM   884  C CD1 B LEU A 1 77  ? 14.85193  -24.95617 -15.50068 0.388 10.04965 ? 158 LEU A CD1 1 
ATOM   885  C CD2 A LEU A 1 77  ? 13.77053  -23.12389 -14.51503 0.612 10.70612 ? 158 LEU A CD2 1 
ATOM   886  C CD2 B LEU A 1 77  ? 13.87679  -23.04921 -14.24406 0.388 10.30194 ? 158 LEU A CD2 1 
ATOM   887  N N   . VAL A 1 78  ? 12.00066  -23.37374 -11.37121 1.000 10.03741 ? 159 VAL A N   1 
ATOM   888  C CA  . VAL A 1 78  ? 11.47893  -22.06889 -10.98636 1.000 10.01282 ? 159 VAL A CA  1 
ATOM   889  C C   . VAL A 1 78  ? 12.50799  -21.01149 -11.37541 1.000 9.04986  ? 159 VAL A C   1 
ATOM   890  O O   . VAL A 1 78  ? 13.70245  -21.15312 -11.07067 1.000 9.14528  ? 159 VAL A O   1 
ATOM   891  C CB  . VAL A 1 78  ? 11.16960  -22.03361 -9.47607  1.000 10.36149 ? 159 VAL A CB  1 
ATOM   892  C CG1 . VAL A 1 78  ? 10.86188  -20.62710 -9.00818  1.000 12.69915 ? 159 VAL A CG1 1 
ATOM   893  C CG2 . VAL A 1 78  ? 9.99875   -22.95385 -9.14338  1.000 10.67029 ? 159 VAL A CG2 1 
ATOM   894  N N   . GLN A 1 79  ? 12.02676  -19.94369 -12.01306 1.000 9.45621  ? 160 GLN A N   1 
ATOM   895  C CA  . GLN A 1 79  ? 12.85064  -18.88019 -12.59167 1.000 10.19810 ? 160 GLN A CA  1 
ATOM   896  C C   . GLN A 1 79  ? 12.69657  -17.60549 -11.77483 1.000 9.19523  ? 160 GLN A C   1 
ATOM   897  O O   . GLN A 1 79  ? 11.58552  -17.07154 -11.66510 1.000 9.49417  ? 160 GLN A O   1 
ATOM   898  C CB  . GLN A 1 79  ? 12.41508  -18.60946 -14.03089 1.000 9.98916  ? 160 GLN A CB  1 
ATOM   899  C CG  . GLN A 1 79  ? 12.51887  -19.80835 -14.92793 1.000 10.09658 ? 160 GLN A CG  1 
ATOM   900  C CD  . GLN A 1 79  ? 12.24083  -19.51821 -16.39527 1.000 10.12207 ? 160 GLN A CD  1 
ATOM   901  O OE1 . GLN A 1 79  ? 12.89416  -20.08362 -17.27038 1.000 11.24397 ? 160 GLN A OE1 1 
ATOM   902  N NE2 . GLN A 1 79  ? 11.27641  -18.64021 -16.67917 1.000 10.57242 ? 160 GLN A NE2 1 
ATOM   903  N N   . ILE A 1 80  ? 13.80554  -17.09674 -11.22834 1.000 9.06785  ? 161 ILE A N   1 
ATOM   904  C CA  . ILE A 1 80  ? 13.75950  -15.93005 -10.35825 1.000 9.65405  ? 161 ILE A CA  1 
ATOM   905  C C   . ILE A 1 80  ? 14.79678  -14.89996 -10.77637 1.000 8.65760  ? 161 ILE A C   1 
ATOM   906  O O   . ILE A 1 80  ? 15.82423  -15.21595 -11.38738 1.000 9.28309  ? 161 ILE A O   1 
ATOM   907  C CB  . ILE A 1 80  ? 13.93159  -16.29372 -8.86205  1.000 9.79007  ? 161 ILE A CB  1 
ATOM   908  C CG1 . ILE A 1 80  ? 15.31392  -16.91245 -8.59236  1.000 11.03664 ? 161 ILE A CG1 1 
ATOM   909  C CG2 . ILE A 1 80  ? 12.80168  -17.20887 -8.41485  1.000 12.23710 ? 161 ILE A CG2 1 
ATOM   910  C CD1 . ILE A 1 80  ? 15.58885  -17.20368 -7.11615  1.000 11.96836 ? 161 ILE A CD1 1 
ATOM   911  N N   . VAL A 1 81  ? 14.51329  -13.64794 -10.41269 1.000 9.53691  ? 162 VAL A N   1 
ATOM   912  C CA  . VAL A 1 81  ? 15.47139  -12.55379 -10.51647 1.000 9.74660  ? 162 VAL A CA  1 
ATOM   913  C C   . VAL A 1 81  ? 15.80719  -12.07953 -9.11370  1.000 9.34242  ? 162 VAL A C   1 
ATOM   914  O O   . VAL A 1 81  ? 14.90819  -11.77996 -8.31278  1.000 9.80973  ? 162 VAL A O   1 
ATOM   915  C CB  . VAL A 1 81  ? 14.93477  -11.38312 -11.34876 1.000 9.81390  ? 162 VAL A CB  1 
ATOM   916  C CG1 . VAL A 1 81  ? 16.05078  -10.37233 -11.61798 1.000 10.19119 ? 162 VAL A CG1 1 
ATOM   917  C CG2 . VAL A 1 81  ? 14.31728  -11.89226 -12.62877 1.000 11.25916 ? 162 VAL A CG2 1 
ATOM   918  N N   . ILE A 1 82  ? 17.09813  -12.04410 -8.80766  1.000 9.26633  ? 163 ILE A N   1 
ATOM   919  C CA  . ILE A 1 82  ? 17.61625  -11.44743 -7.58092  1.000 10.58413 ? 163 ILE A CA  1 
ATOM   920  C C   . ILE A 1 82  ? 17.81454  -9.96199  -7.86381  1.000 9.84835  ? 163 ILE A C   1 
ATOM   921  O O   . ILE A 1 82  ? 18.61588  -9.59767  -8.72527  1.000 10.21014 ? 163 ILE A O   1 
ATOM   922  C CB  . ILE A 1 82  ? 18.93772  -12.12566 -7.18934  1.000 9.89946  ? 163 ILE A CB  1 
ATOM   923  C CG1 . ILE A 1 82  ? 18.78329  -13.65830 -7.15653  1.000 11.39429 ? 163 ILE A CG1 1 
ATOM   924  C CG2 . ILE A 1 82  ? 19.45148  -11.56482 -5.87790  1.000 12.52947 ? 163 ILE A CG2 1 
ATOM   925  C CD1 . ILE A 1 82  ? 17.80060  -14.15768 -6.13577  1.000 13.38861 ? 163 ILE A CD1 1 
ATOM   926  N N   . TYR A 1 83  ? 17.04039  -9.10059  -7.19137  1.000 9.60618  ? 164 TYR A N   1 
ATOM   927  C CA  . TYR A 1 83  ? 16.99574  -7.69603  -7.59391  1.000 10.37617 ? 164 TYR A CA  1 
ATOM   928  C C   . TYR A 1 83  ? 16.68467  -6.82575  -6.37903  1.000 10.23840 ? 164 TYR A C   1 
ATOM   929  O O   . TYR A 1 83  ? 15.62474  -6.19998  -6.28352  1.000 11.68778 ? 164 TYR A O   1 
ATOM   930  C CB  . TYR A 1 83  ? 15.94319  -7.50108  -8.68299  1.000 11.50686 ? 164 TYR A CB  1 
ATOM   931  C CG  . TYR A 1 83  ? 15.90930  -6.14002  -9.32340  1.000 11.51875 ? 164 TYR A CG  1 
ATOM   932  C CD1 . TYR A 1 83  ? 17.03687  -5.60720  -9.91423  1.000 11.52365 ? 164 TYR A CD1 1 
ATOM   933  C CD2 . TYR A 1 83  ? 14.73815  -5.39440  -9.37717  1.000 13.09498 ? 164 TYR A CD2 1 
ATOM   934  C CE1 . TYR A 1 83  ? 17.01544  -4.38006  -10.53334 1.000 14.87489 ? 164 TYR A CE1 1 
ATOM   935  C CE2 . TYR A 1 83  ? 14.70260  -4.15251  -10.00013 1.000 15.04042 ? 164 TYR A CE2 1 
ATOM   936  C CZ  . TYR A 1 83  ? 15.84242  -3.65162  -10.57149 1.000 14.39875 ? 164 TYR A CZ  1 
ATOM   937  O OH  . TYR A 1 83  ? 15.80607  -2.41614  -11.19449 1.000 17.15750 ? 164 TYR A OH  1 
ATOM   938  N N   . ASP A 1 84  ? 17.63034  -6.74131  -5.44237  1.000 10.21813 ? 165 ASP A N   1 
ATOM   939  C CA  . ASP A 1 84  ? 17.38521  -5.91803  -4.26241  1.000 10.47591 ? 165 ASP A CA  1 
ATOM   940  C C   . ASP A 1 84  ? 18.65962  -5.28928  -3.71279  1.000 9.69129  ? 165 ASP A C   1 
ATOM   941  O O   . ASP A 1 84  ? 18.76338  -5.07863  -2.49984  1.000 10.17585 ? 165 ASP A O   1 
ATOM   942  C CB  . ASP A 1 84  ? 16.68019  -6.72764  -3.17679  1.000 11.03564 ? 165 ASP A CB  1 
ATOM   943  C CG  . ASP A 1 84  ? 15.85896  -5.87116  -2.23228  1.000 10.71749 ? 165 ASP A CG  1 
ATOM   944  O OD1 . ASP A 1 84  ? 15.67518  -4.65456  -2.45401  1.000 12.27614 ? 165 ASP A OD1 1 
ATOM   945  O OD2 . ASP A 1 84  ? 15.39051  -6.47201  -1.24266  1.000 11.49284 ? 165 ASP A OD2 1 
ATOM   946  N N   . LEU A 1 85  ? 19.62089  -4.96015  -4.57197  1.000 10.57151 ? 166 LEU A N   1 
ATOM   947  C CA  . LEU A 1 85  ? 20.88054  -4.42624  -4.07556  1.000 10.55648 ? 166 LEU A CA  1 
ATOM   948  C C   . LEU A 1 85  ? 20.66354  -3.12927  -3.29517  1.000 10.36459 ? 166 LEU A C   1 
ATOM   949  O O   . LEU A 1 85  ? 19.77436  -2.33562  -3.61782  1.000 11.29577 ? 166 LEU A O   1 
ATOM   950  C CB  . LEU A 1 85  ? 21.79989  -4.12069  -5.24289  1.000 11.22229 ? 166 LEU A CB  1 
ATOM   951  C CG  . LEU A 1 85  ? 22.55022  -5.33197  -5.77219  1.000 10.80019 ? 166 LEU A CG  1 
ATOM   952  C CD1 . LEU A 1 85  ? 23.31881  -4.95512  -6.98644  1.000 12.62366 ? 166 LEU A CD1 1 
ATOM   953  C CD2 . LEU A 1 85  ? 23.47542  -5.87412  -4.74556  1.000 11.49759 ? 166 LEU A CD2 1 
ATOM   954  N N   . PRO A 1 86  ? 21.49825  -2.87147  -2.28935  1.000 11.28870 ? 167 PRO A N   1 
ATOM   955  C CA  . PRO A 1 86  ? 21.50245  -1.53756  -1.68403  1.000 12.07335 ? 167 PRO A CA  1 
ATOM   956  C C   . PRO A 1 86  ? 21.89234  -0.49760  -2.72866  1.000 11.33920 ? 167 PRO A C   1 
ATOM   957  O O   . PRO A 1 86  ? 22.75543  -0.73611  -3.57252  1.000 11.76053 ? 167 PRO A O   1 
ATOM   958  C CB  . PRO A 1 86  ? 22.55654  -1.64465  -0.57309  1.000 13.95489 ? 167 PRO A CB  1 
ATOM   959  C CG  . PRO A 1 86  ? 22.86602  -3.11689  -0.42974  1.000 14.66382 ? 167 PRO A CG  1 
ATOM   960  C CD  . PRO A 1 86  ? 22.58234  -3.71713  -1.76862  1.000 11.10493 ? 167 PRO A CD  1 
ATOM   961  N N   . ASP A 1 87  ? 21.24675  0.66957   -2.66101  1.000 12.10537 ? 168 ASP A N   1 
ATOM   962  C CA  . ASP A 1 87  ? 21.46233  1.72925   -3.65007  1.000 12.18412 ? 168 ASP A CA  1 
ATOM   963  C C   . ASP A 1 87  ? 21.23210  1.19248   -5.06180  1.000 12.20253 ? 168 ASP A C   1 
ATOM   964  O O   . ASP A 1 87  ? 22.00871  1.44913   -5.98452  1.000 12.59744 ? 168 ASP A O   1 
ATOM   965  C CB  . ASP A 1 87  ? 22.85676  2.35921   -3.52511  1.000 14.04958 ? 168 ASP A CB  1 
ATOM   966  C CG  . ASP A 1 87  ? 22.97782  3.35760   -2.37615  1.000 14.50409 ? 168 ASP A CG  1 
ATOM   967  O OD1 . ASP A 1 87  ? 22.25130  3.24989   -1.37682  1.000 14.06445 ? 168 ASP A OD1 1 
ATOM   968  O OD2 . ASP A 1 87  ? 23.83029  4.26983   -2.48247  1.000 17.12153 ? 168 ASP A OD2 1 
ATOM   969  N N   . ARG A 1 88  ? 20.16644  0.40867   -5.21249  1.000 13.28666 ? 169 ARG A N   1 
ATOM   970  C CA  . ARG A 1 88  ? 19.87649  -0.26730  -6.47020  1.000 12.12528 ? 169 ARG A CA  1 
ATOM   971  C C   . ARG A 1 88  ? 19.70729  0.75879   -7.59276  1.000 12.46170 ? 169 ARG A C   1 
ATOM   972  O O   . ARG A 1 88  ? 19.21435  1.87020   -7.37317  1.000 14.72939 ? 169 ARG A O   1 
ATOM   973  C CB  . ARG A 1 88  ? 18.58222  -1.06347  -6.29127  1.000 13.28739 ? 169 ARG A CB  1 
ATOM   974  C CG  . ARG A 1 88  ? 18.25642  -2.05577  -7.39842  1.000 14.21190 ? 169 ARG A CG  1 
ATOM   975  C CD  . ARG A 1 88  ? 17.02045  -2.87490  -7.01451  1.000 13.86879 ? 169 ARG A CD  1 
ATOM   976  N NE  . ARG A 1 88  ? 15.79758  -2.09267  -7.15824  1.000 15.02188 ? 169 ARG A NE  1 
ATOM   977  C CZ  . ARG A 1 88  ? 14.62648  -2.45998  -6.66806  1.000 15.53839 ? 169 ARG A CZ  1 
ATOM   978  N NH1 . ARG A 1 88  ? 14.48038  -3.59860  -6.02750  1.000 13.91870 ? 169 ARG A NH1 1 
ATOM   979  N NH2 . ARG A 1 88  ? 13.57756  -1.65118  -6.80642  1.000 21.34957 ? 169 ARG A NH2 1 
ATOM   980  N N   A ASN A 1 89  ? 20.13907  0.40184   -8.80185  0.642 11.94920 ? 170 ASN A N   1 
ATOM   981  N N   B ASN A 1 89  ? 20.08975  0.34909   -8.80206  0.358 12.02437 ? 170 ASN A N   1 
ATOM   982  C CA  A ASN A 1 89  ? 20.00418  1.27029   -9.98166  0.642 13.57990 ? 170 ASN A CA  1 
ATOM   983  C CA  B ASN A 1 89  ? 20.10421  1.18281   -10.00409 0.358 13.82504 ? 170 ASN A CA  1 
ATOM   984  C C   A ASN A 1 89  ? 20.76075  2.58814   -9.81134  0.642 13.21432 ? 170 ASN A C   1 
ATOM   985  C C   B ASN A 1 89  ? 20.75080  2.54236   -9.73580  0.358 13.19458 ? 170 ASN A C   1 
ATOM   986  O O   A ASN A 1 89  ? 20.19009  3.67375   -9.91964  0.642 13.37369 ? 170 ASN A O   1 
ATOM   987  O O   B ASN A 1 89  ? 20.10499  3.59221   -9.69551  0.358 14.56473 ? 170 ASN A O   1 
ATOM   988  C CB  A ASN A 1 89  ? 18.53699  1.54077   -10.33177 0.642 15.88587 ? 170 ASN A CB  1 
ATOM   989  C CB  B ASN A 1 89  ? 18.73423  1.29649   -10.68010 0.358 14.84437 ? 170 ASN A CB  1 
ATOM   990  C CG  A ASN A 1 89  ? 17.67845  0.31371   -10.22383 0.642 15.92999 ? 170 ASN A CG  1 
ATOM   991  C CG  B ASN A 1 89  ? 18.85389  1.59466   -12.16271 0.358 19.84398 ? 170 ASN A CG  1 
ATOM   992  O OD1 A ASN A 1 89  ? 16.91918  0.15536   -9.26858  0.642 18.33922 ? 170 ASN A OD1 1 
ATOM   993  O OD1 B ASN A 1 89  ? 19.95741  1.80735   -12.67107 0.358 18.04575 ? 170 ASN A OD1 1 
ATOM   994  N ND2 A ASN A 1 89  ? 17.78416  -0.56015  -11.20800 0.642 14.85424 ? 170 ASN A ND2 1 
ATOM   995  N ND2 B ASN A 1 89  ? 17.72303  1.62815   -12.85916 0.358 20.64837 ? 170 ASN A ND2 1 
ATOM   996  N N   . CYS A 1 90  ? 22.06884  2.47921   -9.57720  1.000 11.66306 ? 171 CYS A N   1 
ATOM   997  C CA  . CYS A 1 90  ? 22.84102  3.65405   -9.20539  1.000 12.02554 ? 171 CYS A CA  1 
ATOM   998  C C   . CYS A 1 90  ? 22.84332  4.75415   -10.25737 1.000 13.26432 ? 171 CYS A C   1 
ATOM   999  O O   . CYS A 1 90  ? 23.09711  5.90833   -9.91045  1.000 13.41982 ? 171 CYS A O   1 
ATOM   1000 C CB  . CYS A 1 90  ? 24.27866  3.26816   -8.86798  1.000 13.46594 ? 171 CYS A CB  1 
ATOM   1001 S SG  . CYS A 1 90  ? 25.18545  2.45251   -10.20272 1.000 12.30524 ? 171 CYS A SG  1 
ATOM   1002 N N   A ALA A 1 91  ? 22.68430  4.42289   -11.53424 0.705 13.14352 ? 172 ALA A N   1 
ATOM   1003 N N   B ALA A 1 91  ? 22.49480  4.45576   -11.50652 0.295 12.86382 ? 172 ALA A N   1 
ATOM   1004 C CA  A ALA A 1 91  ? 22.74283  5.45829   -12.56084 0.705 15.24464 ? 172 ALA A CA  1 
ATOM   1005 C CA  B ALA A 1 91  ? 22.39583  5.52870   -12.49115 0.295 14.37949 ? 172 ALA A CA  1 
ATOM   1006 C C   A ALA A 1 91  ? 21.37185  6.01512   -12.89059 0.705 18.44461 ? 172 ALA A C   1 
ATOM   1007 C C   B ALA A 1 91  ? 21.14875  6.38843   -12.31847 0.295 16.07728 ? 172 ALA A C   1 
ATOM   1008 O O   A ALA A 1 91  ? 21.26911  6.96705   -13.67329 0.705 19.28951 ? 172 ALA A O   1 
ATOM   1009 O O   B ALA A 1 91  ? 21.09749  7.48871   -12.87713 0.295 18.00236 ? 172 ALA A O   1 
ATOM   1010 C CB  A ALA A 1 91  ? 23.43935  4.93870   -13.82321 0.705 17.42029 ? 172 ALA A CB  1 
ATOM   1011 C CB  B ALA A 1 91  ? 22.44398  4.95554   -13.90920 0.295 16.61155 ? 172 ALA A CB  1 
ATOM   1012 N N   A ALA A 1 92  ? 20.32824  5.46087   -12.29093 0.705 16.51434 ? 173 ALA A N   1 
ATOM   1013 N N   B ALA A 1 92  ? 20.16624  5.93264   -11.54300 0.295 16.20385 ? 173 ALA A N   1 
ATOM   1014 C CA  A ALA A 1 92  ? 18.98644  5.93323   -12.54564 0.705 22.03986 ? 173 ALA A CA  1 
ATOM   1015 C CA  B ALA A 1 92  ? 18.84754  6.54389   -11.51618 0.295 19.47704 ? 173 ALA A CA  1 
ATOM   1016 C C   A ALA A 1 92  ? 18.73030  7.22147   -11.78327 0.705 22.33393 ? 173 ALA A C   1 
ATOM   1017 C C   B ALA A 1 92  ? 18.77801  7.69237   -10.51006 0.295 25.86640 ? 173 ALA A C   1 
ATOM   1018 O O   A ALA A 1 92  ? 19.38855  7.54218   -10.79022 0.705 25.81304 ? 173 ALA A O   1 
ATOM   1019 O O   B ALA A 1 92  ? 19.75599  8.04230   -9.84482  0.295 25.16251 ? 173 ALA A O   1 
ATOM   1020 C CB  A ALA A 1 92  ? 17.95819  4.89262   -12.11502 0.705 17.33960 ? 173 ALA A CB  1 
ATOM   1021 C CB  B ALA A 1 92  ? 17.77362  5.49132   -11.24631 0.295 18.91836 ? 173 ALA A CB  1 
ATOM   1022 N N   A LYS A 1 93  ? 17.74497  7.95997   -12.26513 0.705 26.29389 ? 174 LYS A N   1 
ATOM   1023 N N   B LYS A 1 93  ? 17.58657  8.27839   -10.39391 0.295 29.00725 ? 174 LYS A N   1 
ATOM   1024 C CA  A LYS A 1 93  ? 17.33983  9.19685   -11.62849 0.705 30.02539 ? 174 LYS A CA  1 
ATOM   1025 C CA  B LYS A 1 93  ? 17.36944  9.46273   -9.57176  0.295 30.35515 ? 174 LYS A CA  1 
ATOM   1026 C C   A LYS A 1 93  ? 16.33425  8.87009   -10.53126 0.705 29.00896 ? 174 LYS A C   1 
ATOM   1027 C C   B LYS A 1 93  ? 17.36270  9.12173   -8.08677  0.295 30.02278 ? 174 LYS A C   1 
ATOM   1028 O O   A LYS A 1 93  ? 15.33664  8.18627   -10.78193 0.705 31.01340 ? 174 LYS A O   1 
ATOM   1029 O O   B LYS A 1 93  ? 18.41181  9.14159   -7.43435  0.295 30.09620 ? 174 LYS A O   1 
ATOM   1030 C CB  A LYS A 1 93  ? 16.73574  10.10232  -12.69825 0.705 29.05946 ? 174 LYS A CB  1 
ATOM   1031 C CB  B LYS A 1 93  ? 16.05939  10.15536  -9.96173  0.295 31.77620 ? 174 LYS A CB  1 
ATOM   1032 C CG  A LYS A 1 93  ? 17.62559  10.16174  -13.94572 0.705 31.46496 ? 174 LYS A CG  1 
ATOM   1033 C CG  B LYS A 1 93  ? 15.72175  10.09707  -11.44814 0.295 29.94314 ? 174 LYS A CG  1 
ATOM   1034 C CD  A LYS A 1 93  ? 16.91120  10.71136  -15.16502 0.705 30.35745 ? 174 LYS A CD  1 
ATOM   1035 C CD  B LYS A 1 93  ? 16.83291  10.68496  -12.30934 0.295 31.89909 ? 174 LYS A CD  1 
ATOM   1036 C CE  A LYS A 1 93  ? 17.87851  10.89707  -16.32932 0.705 33.43756 ? 174 LYS A CE  1 
ATOM   1037 C CE  B LYS A 1 93  ? 16.90497  10.00127  -13.66826 0.295 28.79213 ? 174 LYS A CE  1 
ATOM   1038 N NZ  A LYS A 1 93  ? 17.26460  10.58638  -17.64975 0.705 33.06443 ? 174 LYS A NZ  1 
ATOM   1039 N NZ  B LYS A 1 93  ? 17.47314  8.63029   -13.58373 0.295 29.17252 ? 174 LYS A NZ  1 
ATOM   1040 N N   A ALA A 1 94  ? 16.63284  9.32563   -9.30883  0.705 32.86257 ? 175 ALA A N   1 
ATOM   1041 N N   B ALA A 1 94  ? 16.18900  8.81600   -7.54469  0.295 31.55902 ? 175 ALA A N   1 
ATOM   1042 C CA  A ALA A 1 94  ? 15.83842  9.09303   -8.10148  0.705 34.59274 ? 175 ALA A CA  1 
ATOM   1043 C CA  B ALA A 1 94  ? 16.03130  8.52754   -6.12812  0.295 31.79924 ? 175 ALA A CA  1 
ATOM   1044 C C   A ALA A 1 94  ? 16.08061  7.71735   -7.48591  0.705 35.12536 ? 175 ALA A C   1 
ATOM   1045 C C   B ALA A 1 94  ? 16.05508  7.02388   -5.87981  0.295 32.16178 ? 175 ALA A C   1 
ATOM   1046 O O   A ALA A 1 94  ? 16.46861  6.77014   -8.17905  0.705 33.26483 ? 175 ALA A O   1 
ATOM   1047 O O   B ALA A 1 94  ? 16.02581  6.20925   -6.80568  0.295 31.91938 ? 175 ALA A O   1 
ATOM   1048 C CB  A ALA A 1 94  ? 14.34283  9.37132   -8.30778  0.705 30.81059 ? 175 ALA A CB  1 
ATOM   1049 C CB  B ALA A 1 94  ? 14.72696  9.13334   -5.59962  0.295 33.18832 ? 175 ALA A CB  1 
ATOM   1050 N N   A VAL A 1 95  ? 15.83743  7.60845   -6.18157  0.705 31.18601 ? 176 VAL A N   1 
ATOM   1051 N N   B VAL A 1 95  ? 16.11393  6.66232   -4.59616  0.295 32.05929 ? 176 VAL A N   1 
ATOM   1052 C CA  A VAL A 1 95  ? 16.22414  6.43875   -5.40287  0.705 33.77100 ? 176 VAL A CA  1 
ATOM   1053 C CA  B VAL A 1 95  ? 16.05723  5.25718   -4.21849  0.295 30.90809 ? 176 VAL A CA  1 
ATOM   1054 C C   A VAL A 1 95  ? 15.17620  5.34374   -5.54296  0.705 26.33495 ? 176 VAL A C   1 
ATOM   1055 C C   B VAL A 1 95  ? 14.71465  4.68453   -4.64478  0.295 29.38988 ? 176 VAL A C   1 
ATOM   1056 O O   A VAL A 1 95  ? 13.96468  5.59542   -5.50147  0.705 25.06617 ? 176 VAL A O   1 
ATOM   1057 O O   B VAL A 1 95  ? 13.65305  5.23662   -4.32924  0.295 28.39104 ? 176 VAL A O   1 
ATOM   1058 C CB  A VAL A 1 95  ? 16.45305  6.83329   -3.93262  0.705 32.54756 ? 176 VAL A CB  1 
ATOM   1059 C CB  B VAL A 1 95  ? 16.30976  5.09894   -2.70989  0.295 31.65947 ? 176 VAL A CB  1 
ATOM   1060 C CG1 A VAL A 1 95  ? 16.38808  5.61729   -3.01949  0.705 34.02104 ? 176 VAL A CG1 1 
ATOM   1061 C CG1 B VAL A 1 95  ? 16.11396  6.43048   -1.99069  0.295 29.92235 ? 176 VAL A CG1 1 
ATOM   1062 C CG2 A VAL A 1 95  ? 17.78714  7.55341   -3.78266  0.705 34.21991 ? 176 VAL A CG2 1 
ATOM   1063 C CG2 B VAL A 1 95  ? 15.42109  4.01039   -2.10993  0.295 27.29068 ? 176 VAL A CG2 1 
ATOM   1064 N N   A ASN A 1 96  ? 15.65619  4.11349   -5.70097  0.705 25.54015 ? 177 ASN A N   1 
ATOM   1065 N N   B ASN A 1 96  ? 14.75749  3.58925   -5.40069  0.295 27.14746 ? 177 ASN A N   1 
ATOM   1066 C CA  A ASN A 1 96  ? 14.83173  2.93621   -5.89148  0.705 24.40320 ? 177 ASN A CA  1 
ATOM   1067 C CA  B ASN A 1 96  ? 13.55133  2.90691   -5.84019  0.295 25.63381 ? 177 ASN A CA  1 
ATOM   1068 C C   A ASN A 1 96  ? 15.36498  1.84354   -4.97959  0.705 24.19434 ? 177 ASN A C   1 
ATOM   1069 C C   B ASN A 1 96  ? 13.39994  1.50252   -5.27783  0.295 24.86948 ? 177 ASN A C   1 
ATOM   1070 O O   A ASN A 1 96  ? 16.56107  1.79424   -4.68055  0.705 29.92355 ? 177 ASN A O   1 
ATOM   1071 O O   B ASN A 1 96  ? 12.32584  0.90792   -5.43161  0.295 27.15019 ? 177 ASN A O   1 
ATOM   1072 C CB  A ASN A 1 96  ? 14.94998  2.47876   -7.34197  0.705 28.45919 ? 177 ASN A CB  1 
ATOM   1073 C CB  B ASN A 1 96  ? 13.46229  2.87332   -7.37504  0.295 26.39488 ? 177 ASN A CB  1 
ATOM   1074 C CG  A ASN A 1 96  ? 15.52965  3.56366   -8.24128  0.705 33.22239 ? 177 ASN A CG  1 
ATOM   1075 C CG  B ASN A 1 96  ? 14.80406  3.09471   -8.04553  0.295 30.90805 ? 177 ASN A CG  1 
ATOM   1076 O OD1 A ASN A 1 96  ? 14.80498  4.41701   -8.75350  0.705 35.49987 ? 177 ASN A OD1 1 
ATOM   1077 O OD1 B ASN A 1 96  ? 14.98549  4.06378   -8.78555  0.295 34.42822 ? 177 ASN A OD1 1 
ATOM   1078 N ND2 A ASN A 1 96  ? 16.84987  3.54792   -8.41265  0.705 26.77354 ? 177 ASN A ND2 1 
ATOM   1079 N ND2 B ASN A 1 96  ? 15.74835  2.19384   -7.80100  0.295 25.04138 ? 177 ASN A ND2 1 
ATOM   1080 N N   A GLY A 1 97  ? 14.47147  0.97688   -4.52407  0.705 22.80789 ? 178 GLY A N   1 
ATOM   1081 N N   B GLY A 1 97  ? 14.42895  0.96265   -4.62847  0.295 22.83166 ? 178 GLY A N   1 
ATOM   1082 C CA  A GLY A 1 97  ? 14.89703  -0.13786  -3.69801  0.705 17.98520 ? 178 GLY A CA  1 
ATOM   1083 C CA  B GLY A 1 97  ? 14.33334  -0.33114  -3.98286  0.295 18.77452 ? 178 GLY A CA  1 
ATOM   1084 C C   A GLY A 1 97  ? 14.83542  0.14298   -2.21186  0.705 13.28058 ? 178 GLY A C   1 
ATOM   1085 C C   B GLY A 1 97  ? 13.86808  -0.22988  -2.54605  0.295 20.33963 ? 178 GLY A C   1 
ATOM   1086 O O   A GLY A 1 97  ? 15.08207  1.26967   -1.76250  0.705 14.97653 ? 178 GLY A O   1 
ATOM   1087 O O   B GLY A 1 97  ? 12.73143  0.17550   -2.28240  0.295 22.87997 ? 178 GLY A O   1 
ATOM   1088 N N   A GLU A 1 98  ? 14.51371  -0.89393  -1.43404  0.705 12.40969 ? 179 GLU A N   1 
ATOM   1089 N N   B GLU A 1 98  ? 14.73028  -0.61255  -1.60459  0.295 15.18975 ? 179 GLU A N   1 
ATOM   1090 C CA  A GLU A 1 98  ? 14.30810  -0.75051  0.00401   0.705 12.78411 ? 179 GLU A CA  1 
ATOM   1091 C CA  B GLU A 1 98  ? 14.40441  -0.47330  -0.18978  0.295 15.49739 ? 179 GLU A CA  1 
ATOM   1092 C C   A GLU A 1 98  ? 15.60525  -0.62685  0.79885   0.705 11.52906 ? 179 GLU A C   1 
ATOM   1093 C C   B GLU A 1 98  ? 15.67167  -0.32053  0.64407   0.295 14.36923 ? 179 GLU A C   1 
ATOM   1094 O O   A GLU A 1 98  ? 15.55434  -0.19451  1.95360   0.705 11.63502 ? 179 GLU A O   1 
ATOM   1095 O O   B GLU A 1 98  ? 15.66822  0.38017   1.66084   0.295 16.51518 ? 179 GLU A O   1 
ATOM   1096 C CB  A GLU A 1 98  ? 13.46396  -1.91165  0.54539   0.705 12.86560 ? 179 GLU A CB  1 
ATOM   1097 C CB  B GLU A 1 98  ? 13.58459  -1.66697  0.30934   0.295 14.07700 ? 179 GLU A CB  1 
ATOM   1098 C CG  A GLU A 1 98  ? 14.22147  -3.24503  0.57097   0.705 11.94921 ? 179 GLU A CG  1 
ATOM   1099 C CG  B GLU A 1 98  ? 14.26744  -3.01570  0.10754   0.295 13.03299 ? 179 GLU A CG  1 
ATOM   1100 C CD  A GLU A 1 98  ? 13.33145  -4.43238  0.89608   0.705 11.28967 ? 179 GLU A CD  1 
ATOM   1101 C CD  B GLU A 1 98  ? 13.51711  -4.16550  0.75055   0.295 11.87989 ? 179 GLU A CD  1 
ATOM   1102 O OE1 A GLU A 1 98  ? 12.34819  -4.24307  1.65045   0.705 12.98404 ? 179 GLU A OE1 1 
ATOM   1103 O OE1 B GLU A 1 98  ? 13.21688  -4.07727  1.96184   0.295 20.09124 ? 179 GLU A OE1 1 
ATOM   1104 O OE2 A GLU A 1 98  ? 13.61635  -5.55561  0.42700   0.705 10.11270 ? 179 GLU A OE2 1 
ATOM   1105 O OE2 B GLU A 1 98  ? 13.26067  -5.17334  0.06225   0.295 14.70026 ? 179 GLU A OE2 1 
ATOM   1106 N N   . PHE A 1 99  ? 16.75903  -0.96447  0.22387   1.000 11.67419 ? 180 PHE A N   1 
ATOM   1107 C CA  . PHE A 1 99  ? 18.00323  -0.93605  0.97317   1.000 12.81355 ? 180 PHE A CA  1 
ATOM   1108 C C   . PHE A 1 99  ? 18.92717  0.17062   0.48964   1.000 13.20046 ? 180 PHE A C   1 
ATOM   1109 O O   . PHE A 1 99  ? 19.02872  0.44787   -0.71270  1.000 14.11034 ? 180 PHE A O   1 
ATOM   1110 C CB  . PHE A 1 99  ? 18.73766  -2.27916  0.91051   1.000 12.54887 ? 180 PHE A CB  1 
ATOM   1111 C CG  . PHE A 1 99  ? 17.96310  -3.42321  1.49344   1.000 11.90190 ? 180 PHE A CG  1 
ATOM   1112 C CD1 . PHE A 1 99  ? 17.25060  -3.28039  2.67606   1.000 12.90663 ? 180 PHE A CD1 1 
ATOM   1113 C CD2 . PHE A 1 99  ? 17.93742  -4.64242  0.84234   1.000 13.47858 ? 180 PHE A CD2 1 
ATOM   1114 C CE1 . PHE A 1 99  ? 16.53114  -4.35152  3.21432   1.000 14.44535 ? 180 PHE A CE1 1 
ATOM   1115 C CE2 . PHE A 1 99  ? 17.22080  -5.71935  1.36915   1.000 13.66395 ? 180 PHE A CE2 1 
ATOM   1116 C CZ  . PHE A 1 99  ? 16.51402  -5.57287  2.55267   1.000 14.34135 ? 180 PHE A CZ  1 
ATOM   1117 N N   . SER A 1 100 ? 19.62063  0.78260   1.43549   1.000 12.50274 ? 181 SER A N   1 
ATOM   1118 C CA  . SER A 1 100 ? 20.56069  1.84731   1.13196   1.000 12.44723 ? 181 SER A CA  1 
ATOM   1119 C C   . SER A 1 100 ? 21.89530  1.52076   1.76701   1.000 12.35211 ? 181 SER A C   1 
ATOM   1120 O O   . SER A 1 100 ? 21.95658  0.97603   2.87309   1.000 13.95410 ? 181 SER A O   1 
ATOM   1121 C CB  . SER A 1 100 ? 20.06714  3.18933   1.66329   1.000 15.47178 ? 181 SER A CB  1 
ATOM   1122 O OG  . SER A 1 100 ? 19.96650  3.16274   3.07107   1.000 17.65355 ? 181 SER A OG  1 
ATOM   1123 N N   . ILE A 1 101 ? 22.96350  1.86848   1.05645   1.000 12.28071 ? 182 ILE A N   1 
ATOM   1124 C CA  . ILE A 1 101 ? 24.30707  1.62301   1.56202   1.000 14.69915 ? 182 ILE A CA  1 
ATOM   1125 C C   . ILE A 1 101 ? 24.49875  2.27781   2.91888   1.000 14.34842 ? 182 ILE A C   1 
ATOM   1126 O O   . ILE A 1 101 ? 25.09454  1.68791   3.82893   1.000 16.74956 ? 182 ILE A O   1 
ATOM   1127 C CB  . ILE A 1 101 ? 25.35333  2.08713   0.53573   1.000 14.04006 ? 182 ILE A CB  1 
ATOM   1128 C CG1 . ILE A 1 101 ? 25.27340  1.19643   -0.70430  1.000 14.05243 ? 182 ILE A CG1 1 
ATOM   1129 C CG2 . ILE A 1 101 ? 26.74219  2.06204   1.14698   1.000 17.48329 ? 182 ILE A CG2 1 
ATOM   1130 C CD1 . ILE A 1 101 ? 26.17426  1.62940   -1.81909  1.000 15.60611 ? 182 ILE A CD1 1 
ATOM   1131 N N   . ALA A 1 102 ? 23.95877  3.48685   3.08867   1.000 13.52748 ? 183 ALA A N   1 
ATOM   1132 C CA  . ALA A 1 102 ? 24.14853  4.25852   4.31060   1.000 17.51667 ? 183 ALA A CA  1 
ATOM   1133 C C   . ALA A 1 102 ? 23.43562  3.66463   5.51942   1.000 16.72472 ? 183 ALA A C   1 
ATOM   1134 O O   . ALA A 1 102 ? 23.80303  3.98851   6.65259   1.000 20.39695 ? 183 ALA A O   1 
ATOM   1135 C CB  . ALA A 1 102 ? 23.64958  5.68342   4.08561   1.000 19.99318 ? 183 ALA A CB  1 
ATOM   1136 N N   A ASN A 1 103 ? 22.44318  2.80617   5.31320   0.574 14.28895 ? 184 ASN A N   1 
ATOM   1137 N N   B ASN A 1 103 ? 22.42678  2.82706   5.30872   0.426 14.31273 ? 184 ASN A N   1 
ATOM   1138 C CA  A ASN A 1 103 ? 21.65854  2.20308   6.39177   0.574 14.80388 ? 184 ASN A CA  1 
ATOM   1139 C CA  B ASN A 1 103 ? 21.65222  2.21677   6.38639   0.426 14.81711 ? 184 ASN A CA  1 
ATOM   1140 C C   A ASN A 1 103 ? 21.85455  0.68875   6.33957   0.574 14.14456 ? 184 ASN A C   1 
ATOM   1141 C C   B ASN A 1 103 ? 21.84068  0.70495   6.33496   0.426 14.14155 ? 184 ASN A C   1 
ATOM   1142 O O   A ASN A 1 103 ? 20.92594  -0.05967  6.03275   0.574 14.23676 ? 184 ASN A O   1 
ATOM   1143 O O   B ASN A 1 103 ? 20.93093  -0.03624  5.95993   0.426 14.30258 ? 184 ASN A O   1 
ATOM   1144 C CB  A ASN A 1 103 ? 20.15797  2.59904   6.23956   0.574 15.63635 ? 184 ASN A CB  1 
ATOM   1145 C CB  B ASN A 1 103 ? 20.17334  2.59058   6.27362   0.426 15.60768 ? 184 ASN A CB  1 
ATOM   1146 C CG  A ASN A 1 103 ? 19.27333  2.06468   7.36512   0.574 13.59435 ? 184 ASN A CG  1 
ATOM   1147 C CG  B ASN A 1 103 ? 19.89870  4.02048   6.69465   0.426 15.11789 ? 184 ASN A CG  1 
ATOM   1148 O OD1 A ASN A 1 103 ? 19.70305  1.25481   8.18560   0.574 15.45834 ? 184 ASN A OD1 1 
ATOM   1149 O OD1 B ASN A 1 103 ? 20.69491  4.63801   7.40518   0.426 17.59034 ? 184 ASN A OD1 1 
ATOM   1150 N ND2 A ASN A 1 103 ? 18.02082  2.52395   7.40155   0.574 17.36768 ? 184 ASN A ND2 1 
ATOM   1151 N ND2 B ASN A 1 103 ? 18.76802  4.55613   6.25320   0.426 22.27175 ? 184 ASN A ND2 1 
ATOM   1152 N N   A ASN A 1 104 ? 23.07150  0.23563   6.63224   0.574 13.85628 ? 185 ASN A N   1 
ATOM   1153 N N   B ASN A 1 104 ? 23.04075  0.25053   6.69104   0.426 13.83489 ? 185 ASN A N   1 
ATOM   1154 C CA  A ASN A 1 104 ? 23.36151  -1.19996  6.73176   0.574 14.20065 ? 185 ASN A CA  1 
ATOM   1155 C CA  B ASN A 1 104 ? 23.29027  -1.16729  6.95544   0.426 14.33831 ? 185 ASN A CA  1 
ATOM   1156 C C   A ASN A 1 104 ? 22.88851  -1.96667  5.49498   0.574 12.36813 ? 185 ASN A C   1 
ATOM   1157 C C   B ASN A 1 104 ? 23.08587  -2.02795  5.70926   0.426 14.13189 ? 185 ASN A C   1 
ATOM   1158 O O   A ASN A 1 104 ? 22.40725  -3.09874  5.58435   0.574 13.02999 ? 185 ASN A O   1 
ATOM   1159 O O   B ASN A 1 104 ? 22.77427  -3.21650  5.81144   0.426 14.48007 ? 185 ASN A O   1 
ATOM   1160 C CB  A ASN A 1 104 ? 22.75331  -1.79461  8.00223   0.574 16.39709 ? 185 ASN A CB  1 
ATOM   1161 C CB  B ASN A 1 104 ? 22.40519  -1.65473  8.10654   0.426 15.46471 ? 185 ASN A CB  1 
ATOM   1162 C CG  A ASN A 1 104 ? 22.94508  -0.90256  9.21158   0.574 12.29066 ? 185 ASN A CG  1 
ATOM   1163 C CG  B ASN A 1 104 ? 23.18375  -2.41253  9.14622   0.426 20.45298 ? 185 ASN A CG  1 
ATOM   1164 O OD1 A ASN A 1 104 ? 22.02976  -0.17154  9.62136   0.574 12.36362 ? 185 ASN A OD1 1 
ATOM   1165 O OD1 B ASN A 1 104 ? 23.51313  -3.58257  8.97622   0.426 26.25532 ? 185 ASN A OD1 1 
ATOM   1166 N ND2 A ASN A 1 104 ? 24.14410  -0.94063  9.78228   0.574 14.59137 ? 185 ASN A ND2 1 
ATOM   1167 N ND2 B ASN A 1 104 ? 23.51530  -1.72234  10.23519  0.426 14.50692 ? 185 ASN A ND2 1 
ATOM   1168 N N   A GLY A 1 105 ? 23.02796  -1.33959  4.32643   0.574 12.64246 ? 186 GLY A N   1 
ATOM   1169 N N   B GLY A 1 105 ? 23.29269  -1.43387  4.53022   0.426 12.80303 ? 186 GLY A N   1 
ATOM   1170 C CA  A GLY A 1 105 ? 22.46616  -1.92175  3.11852   0.574 12.52590 ? 186 GLY A CA  1 
ATOM   1171 C CA  B GLY A 1 105 ? 22.84899  -2.06378  3.29614   0.426 13.22440 ? 186 GLY A CA  1 
ATOM   1172 C C   A GLY A 1 105 ? 23.05202  -3.28049  2.79957   0.574 11.57773 ? 186 GLY A C   1 
ATOM   1173 C C   B GLY A 1 105 ? 23.36874  -3.47515  3.11206   0.426 11.33577 ? 186 GLY A C   1 
ATOM   1174 O O   A GLY A 1 105 ? 22.31857  -4.23394  2.52978   0.574 12.73152 ? 186 GLY A O   1 
ATOM   1175 O O   B GLY A 1 105 ? 22.61890  -4.38043  2.73543   0.426 12.50909 ? 186 GLY A O   1 
ATOM   1176 N N   A GLN A 1 106 ? 24.38551  -3.37674  2.79933   0.574 11.46924 ? 187 GLN A N   1 
ATOM   1177 N N   B GLN A 1 106 ? 24.65006  -3.69433  3.40064   0.426 10.90828 ? 187 GLN A N   1 
ATOM   1178 C CA  A GLN A 1 106 ? 25.06295  -4.65557  2.58279   0.574 12.41157 ? 187 GLN A CA  1 
ATOM   1179 C CA  B GLN A 1 106 ? 25.23438  -4.99664  3.11102   0.426 11.19639 ? 187 GLN A CA  1 
ATOM   1180 C C   A GLN A 1 106 ? 24.52413  -5.73285  3.51362   0.574 10.74792 ? 187 GLN A C   1 
ATOM   1181 C C   B GLN A 1 106 ? 24.66150  -6.08906  3.99975   0.426 11.87742 ? 187 GLN A C   1 
ATOM   1182 O O   A GLN A 1 106 ? 24.18371  -6.83797  3.07329   0.574 10.07093 ? 187 GLN A O   1 
ATOM   1183 O O   B GLN A 1 106 ? 24.31182  -7.17092  3.51440   0.426 10.25400 ? 187 GLN A O   1 
ATOM   1184 C CB  A GLN A 1 106 ? 26.56525  -4.47279  2.83321   0.574 13.84953 ? 187 GLN A CB  1 
ATOM   1185 C CB  B GLN A 1 106 ? 26.74598  -4.93217  3.20843   0.426 13.58221 ? 187 GLN A CB  1 
ATOM   1186 C CG  A GLN A 1 106 ? 27.40364  -5.76521  2.89231   0.574 20.03979 ? 187 GLN A CG  1 
ATOM   1187 C CG  B GLN A 1 106 ? 27.34282  -5.10911  1.85808   0.426 20.49504 ? 187 GLN A CG  1 
ATOM   1188 C CD  A GLN A 1 106 ? 27.51403  -6.44417  1.55582   0.574 18.34255 ? 187 GLN A CD  1 
ATOM   1189 C CD  B GLN A 1 106 ? 28.81772  -5.24576  1.91823   0.426 13.35992 ? 187 GLN A CD  1 
ATOM   1190 O OE1 A GLN A 1 106 ? 27.64211  -5.77392  0.53785   0.574 15.89743 ? 187 GLN A OE1 1 
ATOM   1191 O OE1 B GLN A 1 106 ? 29.51773  -4.37006  1.43237   0.426 13.49286 ? 187 GLN A OE1 1 
ATOM   1192 N NE2 A GLN A 1 106 ? 27.50282  -7.77790  1.54580   0.574 15.34006 ? 187 GLN A NE2 1 
ATOM   1193 N NE2 B GLN A 1 106 ? 29.31030  -6.34064  2.49687   0.426 15.63026 ? 187 GLN A NE2 1 
ATOM   1194 N N   A ALA A 1 107 ? 24.47819  -5.43482  4.81638   0.574 10.75846 ? 188 ALA A N   1 
ATOM   1195 N N   B ALA A 1 107 ? 24.55447  -5.83462  5.30469   0.426 11.44854 ? 188 ALA A N   1 
ATOM   1196 C CA  A ALA A 1 107 ? 24.06002  -6.43168  5.79476   0.574 11.59959 ? 188 ALA A CA  1 
ATOM   1197 C CA  B ALA A 1 107 ? 23.96029  -6.84288  6.17353   0.426 12.80969 ? 188 ALA A CA  1 
ATOM   1198 C C   A ALA A 1 107 ? 22.61261  -6.83462  5.57342   0.574 10.84788 ? 188 ALA A C   1 
ATOM   1199 C C   B ALA A 1 107 ? 22.50792  -7.08752  5.79976   0.426 12.06860 ? 188 ALA A C   1 
ATOM   1200 O O   A ALA A 1 107 ? 22.26628  -8.01758  5.66563   0.574 11.07059 ? 188 ALA A O   1 
ATOM   1201 O O   B ALA A 1 107 ? 22.02648  -8.22394  5.85641   0.426 14.03666 ? 188 ALA A O   1 
ATOM   1202 C CB  A ALA A 1 107 ? 24.24424  -5.88107  7.21005   0.574 13.79701 ? 188 ALA A CB  1 
ATOM   1203 C CB  B ALA A 1 107 ? 24.08897  -6.42995  7.64102   0.426 12.20153 ? 188 ALA A CB  1 
ATOM   1204 N N   A ASN A 1 108 ? 21.75349  -5.86178  5.27521   0.574 11.79283 ? 189 ASN A N   1 
ATOM   1205 N N   B ASN A 1 108 ? 21.80275  -6.03303  5.39043   0.426 11.59962 ? 189 ASN A N   1 
ATOM   1206 C CA  A ASN A 1 108 ? 20.35977  -6.17518  4.99633   0.574 11.17640 ? 189 ASN A CA  1 
ATOM   1207 C CA  B ASN A 1 108 ? 20.40093  -6.17651  5.01901   0.426 11.17578 ? 189 ASN A CA  1 
ATOM   1208 C C   A ASN A 1 108 ? 20.24031  -7.02649  3.74445   0.574 9.97299  ? 189 ASN A C   1 
ATOM   1209 C C   B ASN A 1 108 ? 20.25076  -7.01610  3.75676   0.426 10.02965 ? 189 ASN A C   1 
ATOM   1210 O O   A ASN A 1 108 ? 19.40703  -7.93858  3.67833   0.574 11.43361 ? 189 ASN A O   1 
ATOM   1211 O O   B ASN A 1 108 ? 19.39231  -7.90279  3.69181   0.426 11.47222 ? 189 ASN A O   1 
ATOM   1212 C CB  A ASN A 1 108 ? 19.57241  -4.87916  4.83068   0.574 13.32318 ? 189 ASN A CB  1 
ATOM   1213 C CB  B ASN A 1 108 ? 19.76661  -4.79615  4.83612   0.426 12.55452 ? 189 ASN A CB  1 
ATOM   1214 C CG  A ASN A 1 108 ? 19.45935  -4.10044  6.11823   0.574 14.29409 ? 189 ASN A CG  1 
ATOM   1215 C CG  B ASN A 1 108 ? 19.36102  -4.16233  6.15447   0.426 14.40591 ? 189 ASN A CG  1 
ATOM   1216 O OD1 A ASN A 1 108 ? 19.65209  -4.64762  7.20976   0.574 13.60967 ? 189 ASN A OD1 1 
ATOM   1217 O OD1 B ASN A 1 108 ? 18.57750  -4.73371  6.90941   0.426 16.69969 ? 189 ASN A OD1 1 
ATOM   1218 N ND2 A ASN A 1 108 ? 19.13623  -2.81736  6.00177   0.574 12.06108 ? 189 ASN A ND2 1 
ATOM   1219 N ND2 B ASN A 1 108 ? 19.86638  -2.96086  6.42118   0.426 15.78064 ? 189 ASN A ND2 1 
ATOM   1220 N N   . TYR A 1 109 ? 21.08158  -6.75344  2.74568   1.000 10.99226 ? 190 TYR A N   1 
ATOM   1221 C CA  . TYR A 1 109 ? 21.05288  -7.55369  1.52854   1.000 11.03412 ? 190 TYR A CA  1 
ATOM   1222 C C   . TYR A 1 109 ? 21.46038  -8.99020  1.81232   1.000 10.27580 ? 190 TYR A C   1 
ATOM   1223 O O   . TYR A 1 109 ? 20.85991  -9.93490  1.28608   1.000 10.27632 ? 190 TYR A O   1 
ATOM   1224 C CB  . TYR A 1 109 ? 21.97865  -6.94411  0.48355   1.000 12.02098 ? 190 TYR A CB  1 
ATOM   1225 C CG  . TYR A 1 109 ? 21.91538  -7.65516  -0.83595  1.000 10.48995 ? 190 TYR A CG  1 
ATOM   1226 C CD1 . TYR A 1 109 ? 20.90623  -7.36318  -1.72927  1.000 10.67888 ? 190 TYR A CD1 1 
ATOM   1227 C CD2 . TYR A 1 109 ? 22.84248  -8.62920  -1.17916  1.000 10.99805 ? 190 TYR A CD2 1 
ATOM   1228 C CE1 . TYR A 1 109 ? 20.80936  -7.98819  -2.94487  1.000 9.85399  ? 190 TYR A CE1 1 
ATOM   1229 C CE2 . TYR A 1 109 ? 22.76091  -9.27575  -2.40274  1.000 10.15633 ? 190 TYR A CE2 1 
ATOM   1230 C CZ  . TYR A 1 109 ? 21.74181  -8.94780  -3.27970  1.000 10.04577 ? 190 TYR A CZ  1 
ATOM   1231 O OH  . TYR A 1 109 ? 21.67777  -9.59082  -4.49180  1.000 10.31051 ? 190 TYR A OH  1 
ATOM   1232 N N   . GLU A 1 110 ? 22.48886  -9.17833  2.63476   1.000 10.96142 ? 191 GLU A N   1 
ATOM   1233 C CA  A GLU A 1 110 ? 22.91283  -10.52690 3.01978   0.578 12.34306 ? 191 GLU A CA  1 
ATOM   1234 C CA  B GLU A 1 110 ? 22.88583  -10.53655 2.93618   0.422 12.41232 ? 191 GLU A CA  1 
ATOM   1235 C C   . GLU A 1 110 ? 21.78205  -11.28139 3.68584   1.000 11.50669 ? 191 GLU A C   1 
ATOM   1236 O O   . GLU A 1 110 ? 21.58695  -12.47860 3.44962   1.000 12.03215 ? 191 GLU A O   1 
ATOM   1237 C CB  A GLU A 1 110 ? 24.09429  -10.46956 3.98862   0.578 13.77238 ? 191 GLU A CB  1 
ATOM   1238 C CB  B GLU A 1 110 ? 24.28580  -10.53299 3.56173   0.422 13.29137 ? 191 GLU A CB  1 
ATOM   1239 C CG  A GLU A 1 110 ? 25.37502  -9.94941  3.39116   0.578 13.66231 ? 191 GLU A CG  1 
ATOM   1240 C CG  B GLU A 1 110 ? 25.31644  -9.91662  2.56790   0.422 14.35665 ? 191 GLU A CG  1 
ATOM   1241 C CD  A GLU A 1 110 ? 26.49606  -9.83405  4.40446   0.578 15.71001 ? 191 GLU A CD  1 
ATOM   1242 C CD  B GLU A 1 110 ? 26.70773  -9.69535  3.14338   0.422 12.03910 ? 191 GLU A CD  1 
ATOM   1243 O OE1 A GLU A 1 110 ? 26.25295  -10.11722 5.59569   0.578 18.26976 ? 191 GLU A OE1 1 
ATOM   1244 O OE1 B GLU A 1 110 ? 26.90977  -10.00877 4.33636   0.422 16.53082 ? 191 GLU A OE1 1 
ATOM   1245 O OE2 A GLU A 1 110 ? 27.61097  -9.43183  4.00472   0.578 16.17468 ? 191 GLU A OE2 1 
ATOM   1246 O OE2 B GLU A 1 110 ? 27.59090  -9.19033  2.40088   0.422 12.81557 ? 191 GLU A OE2 1 
ATOM   1247 N N   . ASN A 1 111 ? 21.00995  -10.58839 4.51975   1.000 11.15094 ? 192 ASN A N   1 
ATOM   1248 C CA  . ASN A 1 111 ? 19.87187  -11.22971 5.16430   1.000 11.70525 ? 192 ASN A CA  1 
ATOM   1249 C C   . ASN A 1 111 ? 18.78432  -11.59092 4.15204   1.000 11.62443 ? 192 ASN A C   1 
ATOM   1250 O O   . ASN A 1 111 ? 18.17048  -12.65866 4.25574   1.000 11.40579 ? 192 ASN A O   1 
ATOM   1251 C CB  . ASN A 1 111 ? 19.35978  -10.34404 6.28984   1.000 14.31952 ? 192 ASN A CB  1 
ATOM   1252 C CG  . ASN A 1 111 ? 18.12965  -10.88639 6.91903   1.000 17.35226 ? 192 ASN A CG  1 
ATOM   1253 O OD1 . ASN A 1 111 ? 17.02992  -10.41486 6.65656   1.000 17.78513 ? 192 ASN A OD1 1 
ATOM   1254 N ND2 . ASN A 1 111 ? 18.29216  -11.92655 7.72871   1.000 18.33668 ? 192 ASN A ND2 1 
ATOM   1255 N N   . TYR A 1 112 ? 18.55839  -10.72420 3.15849   1.000 10.67392 ? 193 TYR A N   1 
ATOM   1256 C CA  . TYR A 1 112 ? 17.66106  -11.03384 2.04646   1.000 10.84779 ? 193 TYR A CA  1 
ATOM   1257 C C   . TYR A 1 112 ? 18.11464  -12.29885 1.31531   1.000 9.53235  ? 193 TYR A C   1 
ATOM   1258 O O   . TYR A 1 112 ? 17.31328  -13.21048 1.07419   1.000 10.68137 ? 193 TYR A O   1 
ATOM   1259 C CB  . TYR A 1 112 ? 17.58226  -9.79858  1.13523   1.000 10.89743 ? 193 TYR A CB  1 
ATOM   1260 C CG  . TYR A 1 112 ? 17.21429  -9.99296  -0.32812  1.000 9.81023  ? 193 TYR A CG  1 
ATOM   1261 C CD1 . TYR A 1 112 ? 15.89284  -9.92925  -0.76057  1.000 10.16988 ? 193 TYR A CD1 1 
ATOM   1262 C CD2 . TYR A 1 112 ? 18.20126  -10.14378 -1.29002  1.000 9.99955  ? 193 TYR A CD2 1 
ATOM   1263 C CE1 . TYR A 1 112 ? 15.57042  -10.05847 -2.10226  1.000 10.28678 ? 193 TYR A CE1 1 
ATOM   1264 C CE2 . TYR A 1 112 ? 17.88764  -10.27474 -2.62572  1.000 10.02261 ? 193 TYR A CE2 1 
ATOM   1265 C CZ  . TYR A 1 112 ? 16.57555  -10.24176 -3.02536  1.000 10.03372 ? 193 TYR A CZ  1 
ATOM   1266 O OH  . TYR A 1 112 ? 16.27860  -10.37925 -4.36516  1.000 11.27749 ? 193 TYR A OH  1 
ATOM   1267 N N   . ILE A 1 113 ? 19.41152  -12.40892 1.00634   1.000 9.52222  ? 194 ILE A N   1 
ATOM   1268 C CA  . ILE A 1 113 ? 19.90742  -13.63684 0.38416   1.000 9.54991  ? 194 ILE A CA  1 
ATOM   1269 C C   . ILE A 1 113 ? 19.71647  -14.82635 1.31517   1.000 9.78738  ? 194 ILE A C   1 
ATOM   1270 O O   . ILE A 1 113 ? 19.30769  -15.91066 0.88310   1.000 10.17989 ? 194 ILE A O   1 
ATOM   1271 C CB  . ILE A 1 113 ? 21.38156  -13.48162 -0.02866  1.000 9.57597  ? 194 ILE A CB  1 
ATOM   1272 C CG1 . ILE A 1 113 ? 21.54620  -12.41189 -1.12507  1.000 10.10488 ? 194 ILE A CG1 1 
ATOM   1273 C CG2 . ILE A 1 113 ? 21.97234  -14.84043 -0.43274  1.000 10.64410 ? 194 ILE A CG2 1 
ATOM   1274 C CD1 . ILE A 1 113 ? 20.80792  -12.68823 -2.42021  1.000 10.35396 ? 194 ILE A CD1 1 
ATOM   1275 N N   . ASP A 1 114 ? 20.01482  -14.64802 2.60661   1.000 10.55885 ? 195 ASP A N   1 
ATOM   1276 C CA  . ASP A 1 114 ? 19.88813  -15.77098 3.53115   1.000 10.91110 ? 195 ASP A CA  1 
ATOM   1277 C C   . ASP A 1 114 ? 18.45942  -16.29300 3.56507   1.000 11.06049 ? 195 ASP A C   1 
ATOM   1278 O O   . ASP A 1 114 ? 18.23466  -17.50746 3.63803   1.000 11.19508 ? 195 ASP A O   1 
ATOM   1279 C CB  . ASP A 1 114 ? 20.30838  -15.35302 4.93898   1.000 12.00911 ? 195 ASP A CB  1 
ATOM   1280 C CG  . ASP A 1 114 ? 21.79641  -15.11607 5.07251   1.000 13.54242 ? 195 ASP A CG  1 
ATOM   1281 O OD1 . ASP A 1 114 ? 22.58344  -15.55370 4.20926   1.000 13.37589 ? 195 ASP A OD1 1 
ATOM   1282 O OD2 . ASP A 1 114 ? 22.17425  -14.48880 6.07925   1.000 14.87838 ? 195 ASP A OD2 1 
ATOM   1283 N N   . GLN A 1 115 ? 17.48232  -15.39097 3.51051   1.000 10.22508 ? 196 GLN A N   1 
ATOM   1284 C CA  . GLN A 1 115 ? 16.08451  -15.80077 3.53289   1.000 10.50783 ? 196 GLN A CA  1 
ATOM   1285 C C   . GLN A 1 115 ? 15.72292  -16.56215 2.26182   1.000 10.50143 ? 196 GLN A C   1 
ATOM   1286 O O   . GLN A 1 115 ? 14.95104  -17.52837 2.30216   1.000 11.16750 ? 196 GLN A O   1 
ATOM   1287 C CB  . GLN A 1 115 ? 15.23054  -14.54416 3.69149   1.000 12.23155 ? 196 GLN A CB  1 
ATOM   1288 C CG  . GLN A 1 115 ? 15.24720  -13.95813 5.10649   1.000 14.45542 ? 196 GLN A CG  1 
ATOM   1289 C CD  . GLN A 1 115 ? 14.28960  -12.78926 5.25122   1.000 17.54666 ? 196 GLN A CD  1 
ATOM   1290 O OE1 . GLN A 1 115 ? 13.10459  -12.88815 4.94638   1.000 18.35316 ? 196 GLN A OE1 1 
ATOM   1291 N NE2 . GLN A 1 115 ? 14.81311  -11.65938 5.71890   1.000 19.24229 ? 196 GLN A NE2 1 
ATOM   1292 N N   . ILE A 1 116 ? 16.26612  -16.13127 1.12081   1.000 10.59861 ? 197 ILE A N   1 
ATOM   1293 C CA  . ILE A 1 116 ? 16.03623  -16.83874 -0.13373  1.000 11.26741 ? 197 ILE A CA  1 
ATOM   1294 C C   . ILE A 1 116 ? 16.66560  -18.22629 -0.09089  1.000 10.38732 ? 197 ILE A C   1 
ATOM   1295 O O   . ILE A 1 116 ? 16.03521  -19.22618 -0.46369  1.000 10.90529 ? 197 ILE A O   1 
ATOM   1296 C CB  . ILE A 1 116 ? 16.56434  -16.00524 -1.31387  1.000 10.79505 ? 197 ILE A CB  1 
ATOM   1297 C CG1 . ILE A 1 116 ? 15.67956  -14.77270 -1.50663  1.000 10.55070 ? 197 ILE A CG1 1 
ATOM   1298 C CG2 . ILE A 1 116 ? 16.65254  -16.83354 -2.58075  1.000 10.79592 ? 197 ILE A CG2 1 
ATOM   1299 C CD1 . ILE A 1 116 ? 16.30377  -13.69706 -2.38342  1.000 11.44952 ? 197 ILE A CD1 1 
ATOM   1300 N N   . VAL A 1 117 ? 17.91581  -18.30683 0.36879   1.000 10.37751 ? 198 VAL A N   1 
ATOM   1301 C CA  . VAL A 1 117 ? 18.59956  -19.58904 0.48447   1.000 10.89336 ? 198 VAL A CA  1 
ATOM   1302 C C   . VAL A 1 117 ? 17.81375  -20.51851 1.39607   1.000 10.93288 ? 198 VAL A C   1 
ATOM   1303 O O   . VAL A 1 117 ? 17.66972  -21.71458 1.11315   1.000 11.74798 ? 198 VAL A O   1 
ATOM   1304 C CB  . VAL A 1 117 ? 20.04061  -19.36988 0.98447   1.000 10.95383 ? 198 VAL A CB  1 
ATOM   1305 C CG1 . VAL A 1 117 ? 20.68516  -20.68849 1.37997   1.000 13.03368 ? 198 VAL A CG1 1 
ATOM   1306 C CG2 . VAL A 1 117 ? 20.88158  -18.67432 -0.06839  1.000 12.36381 ? 198 VAL A CG2 1 
ATOM   1307 N N   A ALA A 1 118 ? 17.29480  -19.98509 2.50847   0.811 11.56779 ? 199 ALA A N   1 
ATOM   1308 N N   B ALA A 1 118 ? 17.26662  -19.98263 2.49154   0.189 11.57488 ? 199 ALA A N   1 
ATOM   1309 C CA  A ALA A 1 118 ? 16.59322  -20.82952 3.46814   0.811 12.45488 ? 199 ALA A CA  1 
ATOM   1310 C CA  B ALA A 1 118 ? 16.44232  -20.79950 3.37751   0.189 12.48588 ? 199 ALA A CA  1 
ATOM   1311 C C   A ALA A 1 118 ? 15.33000  -21.43159 2.86978   0.811 10.71298 ? 199 ALA A C   1 
ATOM   1312 C C   B ALA A 1 118 ? 15.16940  -21.27135 2.68649   0.189 11.46726 ? 199 ALA A C   1 
ATOM   1313 O O   A ALA A 1 118 ? 14.96773  -22.56046 3.20712   0.811 10.93650 ? 199 ALA A O   1 
ATOM   1314 O O   B ALA A 1 118 ? 14.61170  -22.31185 3.05376   0.189 12.51556 ? 199 ALA A O   1 
ATOM   1315 C CB  A ALA A 1 118 ? 16.27355  -20.05210 4.74208   0.811 13.90151 ? 199 ALA A CB  1 
ATOM   1316 C CB  B ALA A 1 118 ? 16.10204  -20.01874 4.64737   0.189 14.02475 ? 199 ALA A CB  1 
ATOM   1317 N N   A GLN A 1 119 ? 14.65101  -20.70125 1.97871   0.811 10.65683 ? 200 GLN A N   1 
ATOM   1318 N N   B GLN A 1 119 ? 14.69873  -20.52373 1.68729   0.189 11.55159 ? 200 GLN A N   1 
ATOM   1319 C CA  A GLN A 1 119 ? 13.53294  -21.27922 1.23979   0.811 9.55406  ? 200 GLN A CA  1 
ATOM   1320 C CA  B GLN A 1 119 ? 13.50481  -20.91414 0.94691   0.189 10.79090 ? 200 GLN A CA  1 
ATOM   1321 C C   A GLN A 1 119 ? 14.01203  -22.35998 0.27937   0.811 10.05718 ? 200 GLN A C   1 
ATOM   1322 C C   B GLN A 1 119 ? 13.80110  -22.04362 -0.03459  0.189 10.54482 ? 200 GLN A C   1 
ATOM   1323 O O   A GLN A 1 119 ? 13.49977  -23.48343 0.28982   0.811 9.56444  ? 200 GLN A O   1 
ATOM   1324 O O   B GLN A 1 119 ? 13.10042  -23.06249 -0.05319  0.189 12.69572 ? 200 GLN A O   1 
ATOM   1325 C CB  A GLN A 1 119 ? 12.79740  -20.18716 0.46262   0.811 10.13255 ? 200 GLN A CB  1 
ATOM   1326 C CB  B GLN A 1 119 ? 12.92208  -19.69729 0.22357   0.189 11.61363 ? 200 GLN A CB  1 
ATOM   1327 C CG  A GLN A 1 119 ? 12.08028  -19.17343 1.33414   0.811 8.98344  ? 200 GLN A CG  1 
ATOM   1328 C CG  B GLN A 1 119 ? 11.59117  -19.23195 0.78646   0.189 12.20022 ? 200 GLN A CG  1 
ATOM   1329 C CD  A GLN A 1 119 ? 10.76262  -19.69219 1.85415   0.811 9.43155  ? 200 GLN A CD  1 
ATOM   1330 C CD  B GLN A 1 119 ? 11.20285  -19.99323 2.03892   0.189 11.01673 ? 200 GLN A CD  1 
ATOM   1331 O OE1 A GLN A 1 119 ? 10.38042  -20.82631 1.58744   0.811 11.38779 ? 200 GLN A OE1 1 
ATOM   1332 O OE1 B GLN A 1 119 ? 10.55094  -21.03475 1.96619   0.189 10.20468 ? 200 GLN A OE1 1 
ATOM   1333 N NE2 A GLN A 1 119 ? 10.05975  -18.85342 2.60166   0.811 11.23847 ? 200 GLN A NE2 1 
ATOM   1334 N NE2 B GLN A 1 119 ? 11.59545  -19.47222 3.19684   0.189 14.24260 ? 200 GLN A NE2 1 
ATOM   1335 N N   A ILE A 1 120 ? 15.00654  -22.03841 -0.55143  0.811 9.94381  ? 201 ILE A N   1 
ATOM   1336 N N   B ILE A 1 120 ? 14.83725  -21.87573 -0.86022  0.189 10.94971 ? 201 ILE A N   1 
ATOM   1337 C CA  A ILE A 1 120 ? 15.43566  -22.95293 -1.61004  0.811 10.61362 ? 201 ILE A CA  1 
ATOM   1338 C CA  B ILE A 1 120 ? 15.25084  -22.91647 -1.79523  0.189 10.62338 ? 201 ILE A CA  1 
ATOM   1339 C C   A ILE A 1 120 ? 15.94438  -24.27034 -1.02575  0.811 9.85642  ? 201 ILE A C   1 
ATOM   1340 C C   B ILE A 1 120 ? 15.71773  -24.17084 -1.06316  0.189 11.34792 ? 201 ILE A C   1 
ATOM   1341 O O   A ILE A 1 120 ? 15.68700  -25.35398 -1.57075  0.811 11.17167 ? 201 ILE A O   1 
ATOM   1342 O O   B ILE A 1 120 ? 15.64256  -25.27745 -1.61258  0.189 11.23604 ? 201 ILE A O   1 
ATOM   1343 C CB  A ILE A 1 120 ? 16.47655  -22.25451 -2.50890  0.811 10.13452 ? 201 ILE A CB  1 
ATOM   1344 C CB  B ILE A 1 120 ? 16.31066  -22.33455 -2.76319  0.189 11.78473 ? 201 ILE A CB  1 
ATOM   1345 C CG1 A ILE A 1 120 ? 15.83087  -21.07397 -3.25836  0.811 9.66102  ? 201 ILE A CG1 1 
ATOM   1346 C CG1 B ILE A 1 120 ? 15.63440  -21.47134 -3.83124  0.189 12.78181 ? 201 ILE A CG1 1 
ATOM   1347 C CG2 A ILE A 1 120 ? 17.07447  -23.23058 -3.49957  0.811 11.81978 ? 201 ILE A CG2 1 
ATOM   1348 C CG2 B ILE A 1 120 ? 17.14424  -23.42303 -3.41747  0.189 11.90698 ? 201 ILE A CG2 1 
ATOM   1349 C CD1 A ILE A 1 120 ? 16.83419  -20.23426 -4.03854  0.811 10.84567 ? 201 ILE A CD1 1 
ATOM   1350 C CD1 B ILE A 1 120 ? 16.39031  -20.20098 -4.16077  0.189 12.54782 ? 201 ILE A CD1 1 
ATOM   1351 N N   A GLN A 1 121 ? 16.62819  -24.19380 0.11236   0.811 10.21209 ? 202 GLN A N   1 
ATOM   1352 N N   B GLN A 1 121 ? 16.14603  -24.02156 0.19382   0.189 13.28963 ? 202 GLN A N   1 
ATOM   1353 C CA  A GLN A 1 121 ? 17.16498  -25.36487 0.79736   0.811 11.17027 ? 202 GLN A CA  1 
ATOM   1354 C CA  B GLN A 1 121 ? 16.68509  -25.12993 0.97702   0.189 14.02025 ? 202 GLN A CA  1 
ATOM   1355 C C   A GLN A 1 121 ? 16.08471  -26.38510 1.12189   0.811 12.07298 ? 202 GLN A C   1 
ATOM   1356 C C   B GLN A 1 121 ? 15.73181  -26.32022 1.01631   0.189 13.66178 ? 202 GLN A C   1 
ATOM   1357 O O   A GLN A 1 121 ? 16.37419  -27.58257 1.25468   0.811 11.92988 ? 202 GLN A O   1 
ATOM   1358 O O   B GLN A 1 121 ? 16.11725  -27.45258 0.70109   0.189 15.43379 ? 202 GLN A O   1 
ATOM   1359 C CB  A GLN A 1 121 ? 17.77376  -24.88564 2.11105   0.811 14.88417 ? 202 GLN A CB  1 
ATOM   1360 C CB  B GLN A 1 121 ? 16.97022  -24.63722 2.39763   0.189 16.26426 ? 202 GLN A CB  1 
ATOM   1361 C CG  A GLN A 1 121 ? 19.07206  -25.53806 2.52567   0.811 29.28560 ? 202 GLN A CG  1 
ATOM   1362 C CG  B GLN A 1 121 ? 18.40056  -24.81213 2.85465   0.189 22.18796 ? 202 GLN A CG  1 
ATOM   1363 C CD  A GLN A 1 121 ? 19.81527  -24.68198 3.53386   0.811 29.95964 ? 202 GLN A CD  1 
ATOM   1364 C CD  B GLN A 1 121 ? 18.84631  -26.25347 2.80264   0.189 18.42315 ? 202 GLN A CD  1 
ATOM   1365 O OE1 A GLN A 1 121 ? 19.23817  -24.25175 4.53514   0.811 34.43147 ? 202 GLN A OE1 1 
ATOM   1366 O OE1 B GLN A 1 121 ? 19.89614  -26.56749 2.24641   0.189 17.52925 ? 202 GLN A OE1 1 
ATOM   1367 N NE2 A GLN A 1 121 ? 21.09149  -24.41427 3.26962   0.811 33.44395 ? 202 GLN A NE2 1 
ATOM   1368 N NE2 B GLN A 1 121 ? 18.04628  -27.14267 3.37831   0.189 20.77812 ? 202 GLN A NE2 1 
ATOM   1369 N N   A GLN A 1 122 ? 14.84174  -25.93595 1.29306   0.811 10.84418 ? 203 GLN A N   1 
ATOM   1370 N N   B GLN A 1 122 ? 14.47908  -26.08422 1.40084   0.189 13.47537 ? 203 GLN A N   1 
ATOM   1371 C CA  A GLN A 1 122 ? 13.76733  -26.81607 1.73065   0.811 11.16855 ? 203 GLN A CA  1 
ATOM   1372 C CA  B GLN A 1 122 ? 13.55839  -27.18227 1.67024   0.189 12.24695 ? 203 GLN A CA  1 
ATOM   1373 C C   A GLN A 1 122 ? 13.17734  -27.64074 0.60228   0.811 11.62867 ? 203 GLN A C   1 
ATOM   1374 C C   B GLN A 1 122 ? 12.94792  -27.78967 0.41454   0.189 13.47187 ? 203 GLN A C   1 
ATOM   1375 O O   A GLN A 1 122 ? 12.46397  -28.61236 0.88360   0.811 12.89301 ? 203 GLN A O   1 
ATOM   1376 O O   B GLN A 1 122 ? 11.98694  -28.55846 0.52893   0.189 13.59158 ? 203 GLN A O   1 
ATOM   1377 C CB  A GLN A 1 122 ? 12.66519  -26.01068 2.42778   0.811 11.26520 ? 203 GLN A CB  1 
ATOM   1378 C CB  B GLN A 1 122 ? 12.44373  -26.75717 2.63377   0.189 16.05919 ? 203 GLN A CB  1 
ATOM   1379 C CG  A GLN A 1 122 ? 13.12425  -25.47901 3.77491   0.811 12.25422 ? 203 GLN A CG  1 
ATOM   1380 C CG  B GLN A 1 122 ? 12.70729  -25.48783 3.41355   0.189 12.87603 ? 203 GLN A CG  1 
ATOM   1381 C CD  A GLN A 1 122 ? 12.09132  -24.59770 4.42549   0.811 13.27464 ? 203 GLN A CD  1 
ATOM   1382 C CD  B GLN A 1 122 ? 11.64919  -24.43735 3.15638   0.189 14.95932 ? 203 GLN A CD  1 
ATOM   1383 O OE1 A GLN A 1 122 ? 11.11770  -25.08609 5.00439   0.811 13.80807 ? 203 GLN A OE1 1 
ATOM   1384 O OE1 B GLN A 1 122 ? 10.48436  -24.61409 3.51642   0.189 16.99035 ? 203 GLN A OE1 1 
ATOM   1385 N NE2 A GLN A 1 122 ? 12.29857  -23.28643 4.34943   0.811 13.05107 ? 203 GLN A NE2 1 
ATOM   1386 N NE2 B GLN A 1 122 ? 12.04369  -23.34238 2.52128   0.189 16.35860 ? 203 GLN A NE2 1 
ATOM   1387 N N   A PHE A 1 123 ? 13.46071  -27.30763 -0.65627  0.811 12.03641 ? 204 PHE A N   1 
ATOM   1388 N N   B PHE A 1 123 ? 13.46355  -27.47899 -0.77297  0.189 12.27323 ? 204 PHE A N   1 
ATOM   1389 C CA  A PHE A 1 123 ? 12.80218  -27.93992 -1.80004  0.811 11.62655 ? 204 PHE A CA  1 
ATOM   1390 C CA  B PHE A 1 123 ? 12.94688  -28.05517 -2.01586  0.189 12.59872 ? 204 PHE A CA  1 
ATOM   1391 C C   A PHE A 1 123 ? 13.83091  -28.46564 -2.79492  0.811 11.86829 ? 204 PHE A C   1 
ATOM   1392 C C   B PHE A 1 123 ? 14.09442  -28.35830 -2.97207  0.189 13.16429 ? 204 PHE A C   1 
ATOM   1393 O O   A PHE A 1 123 ? 13.89331  -28.01464 -3.95027  0.811 12.30140 ? 204 PHE A O   1 
ATOM   1394 O O   B PHE A 1 123 ? 14.19426  -27.77275 -4.05376  0.189 14.55403 ? 204 PHE A O   1 
ATOM   1395 C CB  A PHE A 1 123 ? 11.81033  -26.97248 -2.44705  0.811 13.26789 ? 204 PHE A CB  1 
ATOM   1396 C CB  B PHE A 1 123 ? 11.91449  -27.12344 -2.64994  0.189 13.16351 ? 204 PHE A CB  1 
ATOM   1397 C CG  A PHE A 1 123 ? 10.85815  -26.36053 -1.45975  0.811 12.32680 ? 204 PHE A CG  1 
ATOM   1398 C CG  B PHE A 1 123 ? 10.81238  -26.72916 -1.71324  0.189 13.15849 ? 204 PHE A CG  1 
ATOM   1399 C CD1 A PHE A 1 123 ? 9.70889   -27.04006 -1.08444  0.811 14.49081 ? 204 PHE A CD1 1 
ATOM   1400 C CD1 B PHE A 1 123 ? 9.78061   -27.60365 -1.42438  0.189 12.53641 ? 204 PHE A CD1 1 
ATOM   1401 C CD2 A PHE A 1 123 ? 11.12331  -25.12459 -0.88917  0.811 12.55172 ? 204 PHE A CD2 1 
ATOM   1402 C CD2 B PHE A 1 123 ? 10.82947  -25.49376 -1.08988  0.189 13.01353 ? 204 PHE A CD2 1 
ATOM   1403 C CE1 A PHE A 1 123 ? 8.84073   -26.49759 -0.16420  0.811 15.67024 ? 204 PHE A CE1 1 
ATOM   1404 C CE1 B PHE A 1 123 ? 8.77748   -27.23687 -0.54866  0.189 11.21849 ? 204 PHE A CE1 1 
ATOM   1405 C CE2 A PHE A 1 123 ? 10.25318  -24.57069 0.02479   0.811 13.60815 ? 204 PHE A CE2 1 
ATOM   1406 C CE2 B PHE A 1 123 ? 9.82764   -25.12590 -0.21725  0.189 14.54965 ? 204 PHE A CE2 1 
ATOM   1407 C CZ  A PHE A 1 123 ? 9.10871   -25.26070 0.38760   0.811 15.73808 ? 204 PHE A CZ  1 
ATOM   1408 C CZ  B PHE A 1 123 ? 8.80276   -25.99914 0.05577   0.189 15.00608 ? 204 PHE A CZ  1 
ATOM   1409 N N   A PRO A 1 124 ? 14.63063  -29.45980 -2.38874  0.811 13.02463 ? 205 PRO A N   1 
ATOM   1410 N N   B PRO A 1 124 ? 14.98095  -29.28911 -2.60488  0.189 14.39326 ? 205 PRO A N   1 
ATOM   1411 C CA  A PRO A 1 124 ? 15.74222  -29.90984 -3.24150  0.811 13.02374 ? 205 PRO A CA  1 
ATOM   1412 C CA  B PRO A 1 124 ? 16.03054  -29.69743 -3.55058  0.189 13.44404 ? 205 PRO A CA  1 
ATOM   1413 C C   A PRO A 1 124 ? 15.31345  -30.60719 -4.51819  0.811 13.71306 ? 205 PRO A C   1 
ATOM   1414 C C   B PRO A 1 124 ? 15.47164  -30.32005 -4.81423  0.189 14.48246 ? 205 PRO A C   1 
ATOM   1415 O O   A PRO A 1 124 ? 16.15778  -30.77243 -5.41067  0.811 14.54177 ? 205 PRO A O   1 
ATOM   1416 O O   B PRO A 1 124 ? 16.13616  -30.28305 -5.85703  0.189 14.48643 ? 205 PRO A O   1 
ATOM   1417 C CB  A PRO A 1 124 ? 16.53801  -30.85092 -2.32345  0.811 15.96353 ? 205 PRO A CB  1 
ATOM   1418 C CB  B PRO A 1 124 ? 16.86314  -30.71072 -2.75139  0.189 14.62431 ? 205 PRO A CB  1 
ATOM   1419 C CG  A PRO A 1 124 ? 15.55934  -31.31235 -1.32482  0.811 15.38044 ? 205 PRO A CG  1 
ATOM   1420 C CG  B PRO A 1 124 ? 16.46997  -30.51752 -1.32480  0.189 16.76335 ? 205 PRO A CG  1 
ATOM   1421 C CD  A PRO A 1 124 ? 14.59356  -30.18192 -1.10604  0.811 13.99594 ? 205 PRO A CD  1 
ATOM   1422 C CD  B PRO A 1 124 ? 15.05722  -30.04250 -1.34245  0.189 13.84977 ? 205 PRO A CD  1 
ATOM   1423 N N   A ASP A 1 125 ? 14.05515  -31.02308 -4.64659  0.811 12.70025 ? 206 ASP A N   1 
ATOM   1424 N N   B ASP A 1 125 ? 14.26375  -30.88003 -4.75418  0.189 13.35877 ? 206 ASP A N   1 
ATOM   1425 C CA  A ASP A 1 125 ? 13.62288  -31.62959 -5.89900  0.811 13.48976 ? 206 ASP A CA  1 
ATOM   1426 C CA  B ASP A 1 125 ? 13.61516  -31.51507 -5.89302  0.189 13.50205 ? 206 ASP A CA  1 
ATOM   1427 C C   A ASP A 1 125 ? 13.20409  -30.60990 -6.95320  0.811 13.29901 ? 206 ASP A C   1 
ATOM   1428 C C   B ASP A 1 125 ? 13.10359  -30.51566 -6.92424  0.189 13.22539 ? 206 ASP A C   1 
ATOM   1429 O O   A ASP A 1 125 ? 12.82678  -31.00735 -8.05787  0.811 13.58516 ? 206 ASP A O   1 
ATOM   1430 O O   B ASP A 1 125 ? 12.52096  -30.93776 -7.92938  0.189 11.61403 ? 206 ASP A O   1 
ATOM   1431 C CB  A ASP A 1 125 ? 12.52598  -32.67617 -5.66655  0.811 14.05923 ? 206 ASP A CB  1 
ATOM   1432 C CB  B ASP A 1 125 ? 12.45645  -32.37274 -5.38906  0.189 13.67462 ? 206 ASP A CB  1 
ATOM   1433 C CG  A ASP A 1 125 ? 11.18079  -32.07265 -5.32120  0.811 18.82951 ? 206 ASP A CG  1 
ATOM   1434 C CG  B ASP A 1 125 ? 11.39125  -31.55299 -4.68695  0.189 14.85883 ? 206 ASP A CG  1 
ATOM   1435 O OD1 A ASP A 1 125 ? 11.13900  -30.97020 -4.74932  0.811 19.70556 ? 206 ASP A OD1 1 
ATOM   1436 O OD1 B ASP A 1 125 ? 11.68788  -30.93033 -3.64173  0.189 13.96140 ? 206 ASP A OD1 1 
ATOM   1437 O OD2 A ASP A 1 125 ? 10.15313  -32.73070 -5.59773  0.811 26.56305 ? 206 ASP A OD2 1 
ATOM   1438 O OD2 B ASP A 1 125 ? 10.24470  -31.55123 -5.17495  0.189 14.65383 ? 206 ASP A OD2 1 
ATOM   1439 N N   A VAL A 1 126 ? 13.29183  -29.31480 -6.65895  0.811 11.15763 ? 207 VAL A N   1 
ATOM   1440 N N   B VAL A 1 126 ? 13.29038  -29.21627 -6.70495  0.189 11.25755 ? 207 VAL A N   1 
ATOM   1441 C CA  A VAL A 1 126 ? 12.96879  -28.25611 -7.60590  0.811 11.29930 ? 207 VAL A CA  1 
ATOM   1442 C CA  B VAL A 1 126 ? 12.89332  -28.18150 -7.65338  0.189 11.35178 ? 207 VAL A CA  1 
ATOM   1443 C C   A VAL A 1 126 ? 14.26584  -27.58338 -8.03620  0.811 11.04561 ? 207 VAL A C   1 
ATOM   1444 C C   B VAL A 1 126 ? 14.13776  -27.40547 -8.05546  0.189 11.48718 ? 207 VAL A C   1 
ATOM   1445 O O   A VAL A 1 126 ? 15.08406  -27.21182 -7.18975  0.811 11.42538 ? 207 VAL A O   1 
ATOM   1446 O O   B VAL A 1 126 ? 14.79970  -26.79695 -7.20559  0.189 10.02367 ? 207 VAL A O   1 
ATOM   1447 C CB  A VAL A 1 126 ? 12.01346  -27.23791 -6.96316  0.811 9.90789  ? 207 VAL A CB  1 
ATOM   1448 C CB  B VAL A 1 126 ? 11.83102  -27.24040 -7.06660  0.189 10.45565 ? 207 VAL A CB  1 
ATOM   1449 C CG1 A VAL A 1 126 ? 11.68174  -26.11658 -7.93591  0.811 11.99435 ? 207 VAL A CG1 1 
ATOM   1450 C CG1 B VAL A 1 126 ? 11.63265  -26.03666 -7.97419  0.189 11.88738 ? 207 VAL A CG1 1 
ATOM   1451 C CG2 A VAL A 1 126 ? 10.74918  -27.92859 -6.46754  0.811 12.21661 ? 207 VAL A CG2 1 
ATOM   1452 C CG2 B VAL A 1 126 ? 10.52149  -27.97871 -6.87929  0.189 10.86541 ? 207 VAL A CG2 1 
ATOM   1453 N N   . ARG A 1 127 ? 14.45125  -27.42420 -9.34591  1.000 9.00091  ? 208 ARG A N   1 
ATOM   1454 C CA  . ARG A 1 127 ? 15.58848  -26.66421 -9.84881  1.000 10.38482 ? 208 ARG A CA  1 
ATOM   1455 C C   . ARG A 1 127 ? 15.23519  -25.18271 -9.87208  1.000 9.65900  ? 208 ARG A C   1 
ATOM   1456 O O   . ARG A 1 127 ? 14.08736  -24.80853 -10.12941 1.000 9.34014  ? 208 ARG A O   1 
ATOM   1457 C CB  . ARG A 1 127 ? 15.93210  -27.12884 -11.25906 1.000 11.34276 ? 208 ARG A CB  1 
ATOM   1458 C CG  . ARG A 1 127 ? 17.09864  -26.39152 -11.88220 1.000 10.09408 ? 208 ARG A CG  1 
ATOM   1459 C CD  . ARG A 1 127 ? 17.62969  -27.11699 -13.08500 1.000 10.88010 ? 208 ARG A CD  1 
ATOM   1460 N NE  . ARG A 1 127 ? 18.42615  -28.26882 -12.67501 1.000 10.48627 ? 208 ARG A NE  1 
ATOM   1461 C CZ  . ARG A 1 127 ? 19.13402  -29.00211 -13.52126 1.000 11.10212 ? 208 ARG A CZ  1 
ATOM   1462 N NH1 . ARG A 1 127 ? 19.14123  -28.74010 -14.82044 1.000 11.61172 ? 208 ARG A NH1 1 
ATOM   1463 N NH2 . ARG A 1 127 ? 19.85386  -30.02004 -13.05534 1.000 12.79372 ? 208 ARG A NH2 1 
ATOM   1464 N N   . VAL A 1 128 ? 16.23006  -24.33452 -9.60659  1.000 8.98914  ? 209 VAL A N   1 
ATOM   1465 C CA  . VAL A 1 128 ? 16.06656  -22.88846 -9.62332  1.000 9.04492  ? 209 VAL A CA  1 
ATOM   1466 C C   . VAL A 1 128 ? 17.10523  -22.29801 -10.56512 1.000 8.77844  ? 209 VAL A C   1 
ATOM   1467 O O   . VAL A 1 128 ? 18.28986  -22.65652 -10.49474 1.000 9.29147  ? 209 VAL A O   1 
ATOM   1468 C CB  . VAL A 1 128 ? 16.21739  -22.29343 -8.21242  1.000 9.55376  ? 209 VAL A CB  1 
ATOM   1469 C CG1 . VAL A 1 128 ? 16.07892  -20.77896 -8.26773  1.000 10.08507 ? 209 VAL A CG1 1 
ATOM   1470 C CG2 . VAL A 1 128 ? 15.19109  -22.88488 -7.26003  1.000 10.86413 ? 209 VAL A CG2 1 
ATOM   1471 N N   . VAL A 1 129 ? 16.65352  -21.42463 -11.45727 1.000 8.63750  ? 210 VAL A N   1 
ATOM   1472 C CA  . VAL A 1 129 ? 17.53019  -20.58602 -12.26330 1.000 8.95645  ? 210 VAL A CA  1 
ATOM   1473 C C   . VAL A 1 129 ? 17.31478  -19.15068 -11.82186 1.000 8.49825  ? 210 VAL A C   1 
ATOM   1474 O O   . VAL A 1 129 ? 16.16904  -18.67451 -11.76079 1.000 9.24043  ? 210 VAL A O   1 
ATOM   1475 C CB  . VAL A 1 129 ? 17.24680  -20.72022 -13.76613 1.000 8.96066  ? 210 VAL A CB  1 
ATOM   1476 C CG1 . VAL A 1 129 ? 18.06635  -19.69948 -14.53818 1.000 11.23720 ? 210 VAL A CG1 1 
ATOM   1477 C CG2 . VAL A 1 129 ? 17.54754  -22.14168 -14.26708 1.000 10.72687 ? 210 VAL A CG2 1 
ATOM   1478 N N   . ALA A 1 130 ? 18.41021  -18.45558 -11.53827 1.000 8.93692  ? 211 ALA A N   1 
ATOM   1479 C CA  . ALA A 1 130 ? 18.35303  -17.07674 -11.07729 1.000 8.73959  ? 211 ALA A CA  1 
ATOM   1480 C C   . ALA A 1 130 ? 19.16884  -16.16270 -11.97863 1.000 8.04313  ? 211 ALA A C   1 
ATOM   1481 O O   . ALA A 1 130 ? 20.33373  -16.45608 -12.29576 1.000 9.44894  ? 211 ALA A O   1 
ATOM   1482 C CB  . ALA A 1 130 ? 18.86296  -16.97580 -9.64035  1.000 10.39907 ? 211 ALA A CB  1 
ATOM   1483 N N   . VAL A 1 131 ? 18.56536  -15.04791 -12.36830 1.000 8.57983  ? 212 VAL A N   1 
ATOM   1484 C CA  . VAL A 1 131 ? 19.28734  -13.91934 -12.94597 1.000 9.17070  ? 212 VAL A CA  1 
ATOM   1485 C C   . VAL A 1 131 ? 19.74375  -13.03099 -11.79853 1.000 9.17245  ? 212 VAL A C   1 
ATOM   1486 O O   . VAL A 1 131 ? 18.94209  -12.64763 -10.93263 1.000 9.51772  ? 212 VAL A O   1 
ATOM   1487 C CB  . VAL A 1 131 ? 18.39498  -13.13523 -13.92507 1.000 9.10546  ? 212 VAL A CB  1 
ATOM   1488 C CG1 . VAL A 1 131 ? 19.05214  -11.80760 -14.29473 1.000 10.10783 ? 212 VAL A CG1 1 
ATOM   1489 C CG2 . VAL A 1 131 ? 18.09810  -13.96191 -15.16801 1.000 10.51293 ? 212 VAL A CG2 1 
ATOM   1490 N N   . ILE A 1 132 ? 21.02882  -12.69759 -11.78291 1.000 8.80513  ? 213 ILE A N   1 
ATOM   1491 C CA  . ILE A 1 132 ? 21.61889  -11.96128 -10.67055 1.000 8.80765  ? 213 ILE A CA  1 
ATOM   1492 C C   . ILE A 1 132 ? 21.71405  -10.48035 -11.01013 1.000 8.59382  ? 213 ILE A C   1 
ATOM   1493 O O   . ILE A 1 132 ? 22.56219  -10.06416 -11.81421 1.000 9.15201  ? 213 ILE A O   1 
ATOM   1494 C CB  . ILE A 1 132 ? 22.98071  -12.51922 -10.24356 1.000 9.41499  ? 213 ILE A CB  1 
ATOM   1495 C CG1 . ILE A 1 132 ? 22.92771  -14.04382 -10.07588 1.000 10.81245 ? 213 ILE A CG1 1 
ATOM   1496 C CG2 . ILE A 1 132 ? 23.43724  -11.82594 -8.95972  1.000 10.66012 ? 213 ILE A CG2 1 
ATOM   1497 C CD1 . ILE A 1 132 ? 21.97011  -14.52674 -9.00575  1.000 11.76183 ? 213 ILE A CD1 1 
ATOM   1498 N N   . GLU A 1 133 ? 20.86010  -9.69537  -10.35133 1.000 8.58634  ? 214 GLU A N   1 
ATOM   1499 C CA  . GLU A 1 133 ? 20.93697  -8.24286  -10.22323 1.000 9.57078  ? 214 GLU A CA  1 
ATOM   1500 C C   . GLU A 1 133 ? 21.06770  -7.45977  -11.52636 1.000 8.91174  ? 214 GLU A C   1 
ATOM   1501 O O   . GLU A 1 133 ? 22.14306  -6.92016  -11.83669 1.000 9.63341  ? 214 GLU A O   1 
ATOM   1502 C CB  . GLU A 1 133 ? 21.98649  -7.84177  -9.18988  1.000 9.60500  ? 214 GLU A CB  1 
ATOM   1503 C CG  . GLU A 1 133 ? 21.67273  -8.32657  -7.77807  1.000 9.86315  ? 214 GLU A CG  1 
ATOM   1504 C CD  . GLU A 1 133 ? 20.49800  -7.62637  -7.10098  1.000 9.50482  ? 214 GLU A CD  1 
ATOM   1505 O OE1 . GLU A 1 133 ? 20.00630  -6.59169  -7.61031  1.000 10.21277 ? 214 GLU A OE1 1 
ATOM   1506 O OE2 . GLU A 1 133 ? 20.07037  -8.13101  -6.04071  1.000 10.75396 ? 214 GLU A OE2 1 
ATOM   1507 N N   A PRO A 1 134 ? 19.99100  -7.39847  -12.31078 0.691 9.07657  ? 215 PRO A N   1 
ATOM   1508 N N   B PRO A 1 134 ? 19.98875  -7.30389  -12.28741 0.309 9.33387  ? 215 PRO A N   1 
ATOM   1509 C CA  A PRO A 1 134 ? 19.97327  -6.51534  -13.47852 0.691 10.11610 ? 215 PRO A CA  1 
ATOM   1510 C CA  B PRO A 1 134 ? 20.00063  -6.31214  -13.37047 0.309 9.36650  ? 215 PRO A CA  1 
ATOM   1511 C C   A PRO A 1 134 ? 20.34894  -5.09695  -13.09166 0.691 9.45941  ? 215 PRO A C   1 
ATOM   1512 C C   B PRO A 1 134 ? 20.43598  -4.94001  -12.86724 0.309 10.59108 ? 215 PRO A C   1 
ATOM   1513 O O   A PRO A 1 134 ? 20.05523  -4.63121  -11.98542 0.691 11.07487 ? 215 PRO A O   1 
ATOM   1514 O O   B PRO A 1 134 ? 20.27840  -4.60617  -11.69058 0.309 9.88327  ? 215 PRO A O   1 
ATOM   1515 C CB  A PRO A 1 134 ? 18.51711  -6.59737  -13.95786 0.691 11.11256 ? 215 PRO A CB  1 
ATOM   1516 C CB  B PRO A 1 134 ? 18.54268  -6.28588  -13.85202 0.309 9.68665  ? 215 PRO A CB  1 
ATOM   1517 C CG  A PRO A 1 134 ? 18.07546  -7.95134  -13.49895 0.691 8.28748  ? 215 PRO A CG  1 
ATOM   1518 C CG  B PRO A 1 134 ? 17.81849  -7.35832  -13.07413 0.309 14.25940 ? 215 PRO A CG  1 
ATOM   1519 C CD  A PRO A 1 134 ? 18.69064  -8.06243  -12.12555 0.691 8.67735  ? 215 PRO A CD  1 
ATOM   1520 C CD  B PRO A 1 134 ? 18.83032  -8.20202  -12.38185 0.309 10.36006 ? 215 PRO A CD  1 
ATOM   1521 N N   A ASP A 1 135 ? 21.01858  -4.41394  -14.01974 0.691 10.96881 ? 216 ASP A N   1 
ATOM   1522 N N   B ASP A 1 135 ? 21.00554  -4.14814  -13.77824 0.309 11.71021 ? 216 ASP A N   1 
ATOM   1523 C CA  A ASP A 1 135 ? 21.35575  -3.00182  -13.84575 0.691 12.54486 ? 216 ASP A CA  1 
ATOM   1524 C CA  B ASP A 1 135 ? 21.39721  -2.76426  -13.49409 0.309 11.44463 ? 216 ASP A CA  1 
ATOM   1525 C C   A ASP A 1 135 ? 22.26625  -2.77744  -12.63945 0.691 10.40523 ? 216 ASP A C   1 
ATOM   1526 C C   B ASP A 1 135 ? 22.39066  -2.65851  -12.34073 0.309 11.32074 ? 216 ASP A C   1 
ATOM   1527 O O   A ASP A 1 135 ? 22.07830  -1.83479  -11.86566 0.691 11.86395 ? 216 ASP A O   1 
ATOM   1528 O O   B ASP A 1 135 ? 22.39534  -1.68233  -11.58635 0.309 10.32226 ? 216 ASP A O   1 
ATOM   1529 C CB  A ASP A 1 135 ? 20.09181  -2.14017  -13.76523 0.691 13.87566 ? 216 ASP A CB  1 
ATOM   1530 C CB  B ASP A 1 135 ? 20.19020  -1.85894  -13.27054 0.309 13.30358 ? 216 ASP A CB  1 
ATOM   1531 C CG  A ASP A 1 135 ? 20.38087  -0.66914  -13.91177 0.691 14.27287 ? 216 ASP A CG  1 
ATOM   1532 C CG  B ASP A 1 135 ? 19.15918  -2.00630  -14.35290 0.309 14.86086 ? 216 ASP A CG  1 
ATOM   1533 O OD1 A ASP A 1 135 ? 21.38375  -0.33390  -14.57100 0.691 15.79496 ? 216 ASP A OD1 1 
ATOM   1534 O OD1 B ASP A 1 135 ? 19.25799  -1.28160  -15.36122 0.309 16.86121 ? 216 ASP A OD1 1 
ATOM   1535 O OD2 A ASP A 1 135 ? 19.62366  0.15149   -13.34417 0.691 16.51417 ? 216 ASP A OD2 1 
ATOM   1536 O OD2 B ASP A 1 135 ? 18.25015  -2.84683  -14.19970 0.309 17.43938 ? 216 ASP A OD2 1 
ATOM   1537 N N   A SER A 1 136 ? 23.26901  -3.64632  -12.47997 0.691 10.19028 ? 217 SER A N   1 
ATOM   1538 N N   B SER A 1 136 ? 23.25167  -3.65894  -12.20310 0.309 10.67757 ? 217 SER A N   1 
ATOM   1539 C CA  A SER A 1 136 ? 24.21634  -3.51598  -11.37658 0.691 10.75869 ? 217 SER A CA  1 
ATOM   1540 C CA  B SER A 1 136 ? 24.28123  -3.57715  -11.17930 0.309 10.85549 ? 217 SER A CA  1 
ATOM   1541 C C   A SER A 1 136 ? 25.65794  -3.55875  -11.87264 0.691 10.49425 ? 217 SER A C   1 
ATOM   1542 C C   B SER A 1 136 ? 25.65021  -3.49013  -11.82363 0.309 10.63583 ? 217 SER A C   1 
ATOM   1543 O O   A SER A 1 136 ? 26.28306  -2.50615  -12.05804 0.691 10.73293 ? 217 SER A O   1 
ATOM   1544 O O   B SER A 1 136 ? 26.11786  -2.39601  -12.14962 0.309 9.72789  ? 217 SER A O   1 
ATOM   1545 C CB  A SER A 1 136 ? 23.95207  -4.55326  -10.26693 0.691 11.35386 ? 217 SER A CB  1 
ATOM   1546 C CB  B SER A 1 136 ? 24.21379  -4.76591  -10.22136 0.309 10.44168 ? 217 SER A CB  1 
ATOM   1547 O OG  A SER A 1 136 ? 24.34930  -5.88111  -10.59664 0.691 9.61889  ? 217 SER A OG  1 
ATOM   1548 O OG  B SER A 1 136 ? 24.08147  -5.99695  -10.90192 0.309 11.14179 ? 217 SER A OG  1 
ATOM   1549 N N   A LEU A 1 137 ? 26.19139  -4.76317  -12.08726 0.691 9.56528  ? 218 LEU A N   1 
ATOM   1550 N N   B LEU A 1 137 ? 26.26889  -4.64836  -12.05703 0.309 9.74782  ? 218 LEU A N   1 
ATOM   1551 C CA  A LEU A 1 137 ? 27.57359  -4.89673  -12.54775 0.691 10.77134 ? 218 LEU A CA  1 
ATOM   1552 C CA  B LEU A 1 137 ? 27.66241  -4.69281  -12.48016 0.309 11.02491 ? 218 LEU A CA  1 
ATOM   1553 C C   A LEU A 1 137 ? 27.85226  -4.06568  -13.79648 0.691 9.59129  ? 218 LEU A C   1 
ATOM   1554 C C   B LEU A 1 137 ? 27.90496  -4.07932  -13.85273 0.309 9.68092  ? 218 LEU A C   1 
ATOM   1555 O O   A LEU A 1 137 ? 28.93176  -3.47577  -13.92827 0.691 9.81475  ? 218 LEU A O   1 
ATOM   1556 O O   B LEU A 1 137 ? 29.03406  -3.66198  -14.12984 0.309 10.50968 ? 218 LEU A O   1 
ATOM   1557 C CB  A LEU A 1 137 ? 27.92115  -6.36627  -12.79540 0.691 10.31053 ? 218 LEU A CB  1 
ATOM   1558 C CB  B LEU A 1 137 ? 28.18393  -6.12647  -12.41499 0.309 12.36787 ? 218 LEU A CB  1 
ATOM   1559 C CG  A LEU A 1 137 ? 27.90889  -7.28428  -11.57115 0.691 10.45518 ? 218 LEU A CG  1 
ATOM   1560 C CG  B LEU A 1 137 ? 27.86778  -6.87553  -11.11823 0.309 10.82598 ? 218 LEU A CG  1 
ATOM   1561 C CD1 A LEU A 1 137 ? 28.27113  -8.70500  -11.95544 0.691 11.48815 ? 218 LEU A CD1 1 
ATOM   1562 C CD1 B LEU A 1 137 ? 28.49311  -8.26112  -11.15860 0.309 12.93521 ? 218 LEU A CD1 1 
ATOM   1563 C CD2 A LEU A 1 137 ? 28.84759  -6.75481  -10.48920 0.691 12.60103 ? 218 LEU A CD2 1 
ATOM   1564 C CD2 B LEU A 1 137 ? 28.38089  -6.08150  -9.92780  0.309 12.81892 ? 218 LEU A CD2 1 
ATOM   1565 N N   . ALA A 1 138 ? 26.89811  -4.02075  -14.72758 1.000 9.57808  ? 219 ALA A N   1 
ATOM   1566 C CA  . ALA A 1 138 ? 27.11862  -3.29914  -15.97523 1.000 10.13982 ? 219 ALA A CA  1 
ATOM   1567 C C   . ALA A 1 138 ? 27.44253  -1.82579  -15.71491 1.000 10.74127 ? 219 ALA A C   1 
ATOM   1568 O O   . ALA A 1 138 ? 28.24994  -1.22769  -16.43981 1.000 11.31154 ? 219 ALA A O   1 
ATOM   1569 C CB  . ALA A 1 138 ? 25.91689  -3.44615  -16.90505 1.000 11.92673 ? 219 ALA A CB  1 
ATOM   1570 N N   . ASN A 1 139 ? 26.85464  -1.23507  -14.66654 1.000 10.76971 ? 220 ASN A N   1 
ATOM   1571 C CA  . ASN A 1 139 ? 27.17995  0.13870   -14.28753 1.000 10.24750 ? 220 ASN A CA  1 
ATOM   1572 C C   . ASN A 1 139 ? 28.61855  0.29038   -13.83909 1.000 11.39738 ? 220 ASN A C   1 
ATOM   1573 O O   . ASN A 1 139 ? 29.17591  1.38933   -13.92708 1.000 11.97614 ? 220 ASN A O   1 
ATOM   1574 C CB  . ASN A 1 139 ? 26.27243  0.61089   -13.15543 1.000 12.33570 ? 220 ASN A CB  1 
ATOM   1575 C CG  . ASN A 1 139 ? 24.87122  0.87071   -13.61350 1.000 12.59305 ? 220 ASN A CG  1 
ATOM   1576 O OD1 . ASN A 1 139 ? 24.64039  1.71561   -14.46711 1.000 12.50127 ? 220 ASN A OD1 1 
ATOM   1577 N ND2 . ASN A 1 139 ? 23.91680  0.11617   -13.06981 1.000 15.96429 ? 220 ASN A ND2 1 
ATOM   1578 N N   . LEU A 1 140 ? 29.21924  -0.77085  -13.31337 1.000 11.57887 ? 221 LEU A N   1 
ATOM   1579 C CA  . LEU A 1 140 ? 30.59627  -0.71692  -12.85703 1.000 11.39270 ? 221 LEU A CA  1 
ATOM   1580 C C   . LEU A 1 140 ? 31.57992  -0.83630  -14.00373 1.000 12.47610 ? 221 LEU A C   1 
ATOM   1581 O O   . LEU A 1 140 ? 32.78158  -0.63759  -13.79940 1.000 14.08530 ? 221 LEU A O   1 
ATOM   1582 C CB  . LEU A 1 140 ? 30.84820  -1.79238  -11.79848 1.000 13.20910 ? 221 LEU A CB  1 
ATOM   1583 C CG  . LEU A 1 140 ? 29.86077  -1.80171  -10.63420 1.000 12.56084 ? 221 LEU A CG  1 
ATOM   1584 C CD1 . LEU A 1 140 ? 30.26178  -2.83760  -9.60158  1.000 13.61673 ? 221 LEU A CD1 1 
ATOM   1585 C CD2 . LEU A 1 140 ? 29.74338  -0.42668  -9.99029  1.000 14.01938 ? 221 LEU A CD2 1 
ATOM   1586 N N   . VAL A 1 141 ? 31.09784  -1.13553  -15.20239 1.000 11.91797 ? 222 VAL A N   1 
ATOM   1587 C CA  . VAL A 1 141 ? 31.94944  -1.08988  -16.38058 1.000 13.36303 ? 222 VAL A CA  1 
ATOM   1588 C C   . VAL A 1 141 ? 32.00129  0.32320   -16.94840 1.000 11.84986 ? 222 VAL A C   1 
ATOM   1589 O O   . VAL A 1 141 ? 33.08022  0.90441   -17.09194 1.000 15.99729 ? 222 VAL A O   1 
ATOM   1590 C CB  . VAL A 1 141 ? 31.48684  -2.11341  -17.43195 1.000 12.03994 ? 222 VAL A CB  1 
ATOM   1591 C CG1 . VAL A 1 141 ? 32.40597  -2.05339  -18.65153 1.000 13.92229 ? 222 VAL A CG1 1 
ATOM   1592 C CG2 . VAL A 1 141 ? 31.44463  -3.52896  -16.84914 1.000 13.15822 ? 222 VAL A CG2 1 
ATOM   1593 N N   A THR A 1 142 ? 30.84425  0.89412   -17.28523 0.735 11.71217 ? 223 THR A N   1 
ATOM   1594 N N   B THR A 1 142 ? 30.83771  0.93396   -17.20754 0.265 11.73436 ? 223 THR A N   1 
ATOM   1595 C CA  A THR A 1 142 ? 30.78331  2.12020   -18.06849 0.735 12.33539 ? 223 THR A CA  1 
ATOM   1596 C CA  B THR A 1 142 ? 30.77729  2.19465   -17.93934 0.265 12.31792 ? 223 THR A CA  1 
ATOM   1597 C C   A THR A 1 142 ? 30.43902  3.36752   -17.27108 0.735 12.50148 ? 223 THR A C   1 
ATOM   1598 C C   B THR A 1 142 ? 30.33583  3.40657   -17.12516 0.265 12.78808 ? 223 THR A C   1 
ATOM   1599 O O   A THR A 1 142 ? 30.60864  4.47618   -17.79904 0.735 13.33730 ? 223 THR A O   1 
ATOM   1600 O O   B THR A 1 142 ? 30.50160  4.53357   -17.60497 0.265 13.82493 ? 223 THR A O   1 
ATOM   1601 C CB  A THR A 1 142 ? 29.74504  1.99546   -19.19484 0.735 12.93322 ? 223 THR A CB  1 
ATOM   1602 C CB  B THR A 1 142 ? 29.83763  2.07182   -19.15078 0.265 13.00248 ? 223 THR A CB  1 
ATOM   1603 O OG1 A THR A 1 142 ? 28.43864  1.87306   -18.62099 0.735 12.79623 ? 223 THR A OG1 1 
ATOM   1604 O OG1 B THR A 1 142 ? 28.47357  2.12585   -18.71046 0.265 12.65786 ? 223 THR A OG1 1 
ATOM   1605 C CG2 A THR A 1 142 ? 30.02490  0.81506   -20.09656 0.735 13.32584 ? 223 THR A CG2 1 
ATOM   1606 C CG2 B THR A 1 142 ? 30.07302  0.77098   -19.89440 0.265 13.69018 ? 223 THR A CG2 1 
ATOM   1607 N N   A ASN A 1 143 ? 29.94757  3.23667   -16.03741 0.735 12.07166 ? 224 ASN A N   1 
ATOM   1608 N N   B ASN A 1 143 ? 29.77816  3.22398   -15.92650 0.265 12.17012 ? 224 ASN A N   1 
ATOM   1609 C CA  A ASN A 1 143 ? 29.34105  4.36004   -15.33193 0.735 13.37833 ? 224 ASN A CA  1 
ATOM   1610 C CA  B ASN A 1 143 ? 29.09948  4.30858   -15.22228 0.265 12.96013 ? 224 ASN A CA  1 
ATOM   1611 C C   A ASN A 1 143 ? 30.03548  4.67237   -14.01106 0.735 11.76974 ? 224 ASN A C   1 
ATOM   1612 C C   B ASN A 1 143 ? 29.76866  4.70286   -13.91003 0.265 12.86589 ? 224 ASN A C   1 
ATOM   1613 O O   A ASN A 1 143 ? 29.41025  5.21276   -13.09752 0.735 11.78201 ? 224 ASN A O   1 
ATOM   1614 O O   B ASN A 1 143 ? 29.10840  5.25307   -13.02739 0.265 11.91249 ? 224 ASN A O   1 
ATOM   1615 C CB  A ASN A 1 143 ? 27.84507  4.13373   -15.11613 0.735 11.85255 ? 224 ASN A CB  1 
ATOM   1616 C CB  B ASN A 1 143 ? 27.62825  3.97719   -14.97562 0.265 13.36634 ? 224 ASN A CB  1 
ATOM   1617 C CG  A ASN A 1 143 ? 27.07714  3.96992   -16.42687 0.735 13.94797 ? 224 ASN A CG  1 
ATOM   1618 C CG  B ASN A 1 143 ? 26.73422  4.46097   -16.08374 0.265 12.62340 ? 224 ASN A CG  1 
ATOM   1619 O OD1 A ASN A 1 143 ? 27.53292  4.40800   -17.49466 0.735 15.22952 ? 224 ASN A OD1 1 
ATOM   1620 O OD1 B ASN A 1 143 ? 27.09127  5.37755   -16.81918 0.265 12.59904 ? 224 ASN A OD1 1 
ATOM   1621 N ND2 A ASN A 1 143 ? 25.91336  3.32274   -16.35444 0.735 13.83643 ? 224 ASN A ND2 1 
ATOM   1622 N ND2 B ASN A 1 143 ? 25.55828  3.85512   -16.20804 0.265 15.15903 ? 224 ASN A ND2 1 
ATOM   1623 N N   A LEU A 1 144 ? 31.33266  4.38884   -13.90653 0.735 11.59479 ? 225 LEU A N   1 
ATOM   1624 N N   B LEU A 1 144 ? 31.07205  4.45773   -13.76526 0.265 11.64693 ? 225 LEU A N   1 
ATOM   1625 C CA  A LEU A 1 144 ? 32.05414  4.76396   -12.69824 0.735 11.30866 ? 225 LEU A CA  1 
ATOM   1626 C CA  B LEU A 1 144 ? 31.73483  4.85634   -12.52685 0.265 11.93433 ? 225 LEU A CA  1 
ATOM   1627 C C   A LEU A 1 144 ? 32.20470  6.27414   -12.54219 0.735 12.90930 ? 225 LEU A C   1 
ATOM   1628 C C   B LEU A 1 144 ? 31.84805  6.37020   -12.38117 0.265 13.11677 ? 225 LEU A C   1 
ATOM   1629 O O   A LEU A 1 144 ? 32.57806  6.72712   -11.45494 0.735 14.09724 ? 225 LEU A O   1 
ATOM   1630 O O   B LEU A 1 144 ? 32.06738  6.85485   -11.26670 0.265 12.60914 ? 225 LEU A O   1 
ATOM   1631 C CB  A LEU A 1 144 ? 33.40828  4.06146   -12.66762 0.735 13.25840 ? 225 LEU A CB  1 
ATOM   1632 C CB  B LEU A 1 144 ? 33.09787  4.17917   -12.37077 0.265 11.75880 ? 225 LEU A CB  1 
ATOM   1633 C CG  A LEU A 1 144 ? 33.28064  2.55206   -12.46236 0.735 13.41284 ? 225 LEU A CG  1 
ATOM   1634 C CG  B LEU A 1 144 ? 33.11887  2.95446   -11.44904 0.265 17.91097 ? 225 LEU A CG  1 
ATOM   1635 C CD1 A LEU A 1 144 ? 34.65595  1.92289   -12.49717 0.735 17.73474 ? 225 LEU A CD1 1 
ATOM   1636 C CD1 B LEU A 1 144 ? 31.70469  2.56501   -10.99339 0.265 10.11859 ? 225 LEU A CD1 1 
ATOM   1637 C CD2 A LEU A 1 144 ? 32.58585  2.23140   -11.14785 0.735 13.88360 ? 225 LEU A CD2 1 
ATOM   1638 C CD2 B LEU A 1 144 ? 33.83741  1.78327   -12.09538 0.265 18.26592 ? 225 LEU A CD2 1 
ATOM   1639 N N   A ASN A 1 145 ? 31.92928  7.05389   -13.58997 0.735 12.28771 ? 226 ASN A N   1 
ATOM   1640 N N   B ASN A 1 145 ? 31.69292  7.12607   -13.47085 0.265 12.66228 ? 226 ASN A N   1 
ATOM   1641 C CA  A ASN A 1 145 ? 31.87748  8.50801   -13.46634 0.735 13.48253 ? 226 ASN A CA  1 
ATOM   1642 C CA  B ASN A 1 145 ? 31.64189  8.57945   -13.35433 0.265 13.10018 ? 226 ASN A CA  1 
ATOM   1643 C C   A ASN A 1 145 ? 30.57895  8.99388   -12.83363 0.735 13.83857 ? 226 ASN A C   1 
ATOM   1644 C C   B ASN A 1 145 ? 30.34703  9.05106   -12.70775 0.265 13.95259 ? 226 ASN A C   1 
ATOM   1645 O O   A ASN A 1 145 ? 30.49851  10.16330  -12.43202 0.735 14.55023 ? 226 ASN A O   1 
ATOM   1646 O O   B ASN A 1 145 ? 30.31842  10.14766  -12.13604 0.265 14.97485 ? 226 ASN A O   1 
ATOM   1647 C CB  A ASN A 1 145 ? 32.08288  9.17740   -14.83110 0.735 13.51374 ? 226 ASN A CB  1 
ATOM   1648 C CB  B ASN A 1 145 ? 31.82625  9.23261   -14.72296 0.265 14.35220 ? 226 ASN A CB  1 
ATOM   1649 C CG  A ASN A 1 145 ? 31.09452  8.68734   -15.89074 0.735 12.80187 ? 226 ASN A CG  1 
ATOM   1650 C CG  B ASN A 1 145 ? 33.27693  9.27888   -15.15288 0.265 13.76424 ? 226 ASN A CG  1 
ATOM   1651 O OD1 A ASN A 1 145 ? 30.87643  7.47665   -16.05867 0.735 15.94743 ? 226 ASN A OD1 1 
ATOM   1652 O OD1 B ASN A 1 145 ? 34.18406  9.34360   -14.32014 0.265 17.84351 ? 226 ASN A OD1 1 
ATOM   1653 N ND2 A ASN A 1 145 ? 30.48987  9.63311   -16.61187 0.735 14.04125 ? 226 ASN A ND2 1 
ATOM   1654 N ND2 B ASN A 1 145 ? 33.50511  9.25094   -16.46000 0.265 17.98180 ? 226 ASN A ND2 1 
ATOM   1655 N N   A VAL A 1 146 ? 29.56457  8.13838   -12.74975 0.735 12.70601 ? 227 VAL A N   1 
ATOM   1656 N N   B VAL A 1 146 ? 29.28234  8.25519   -12.79212 0.265 12.72563 ? 227 VAL A N   1 
ATOM   1657 C CA  A VAL A 1 146 ? 28.34392  8.45500   -12.01839 0.735 13.55594 ? 227 VAL A CA  1 
ATOM   1658 C CA  B VAL A 1 146 ? 28.08187  8.49422   -11.99873 0.265 13.29046 ? 227 VAL A CA  1 
ATOM   1659 C C   A VAL A 1 146 ? 28.66203  8.29215   -10.54227 0.735 12.99683 ? 227 VAL A C   1 
ATOM   1660 C C   B VAL A 1 146 ? 28.46044  8.27750   -10.53885 0.265 12.48805 ? 227 VAL A C   1 
ATOM   1661 O O   A VAL A 1 146 ? 29.04835  7.20642   -10.10447 0.735 13.48996 ? 227 VAL A O   1 
ATOM   1662 O O   B VAL A 1 146 ? 28.69204  7.14153   -10.11908 0.265 10.94558 ? 227 VAL A O   1 
ATOM   1663 C CB  A VAL A 1 146 ? 27.21213  7.50791   -12.43342 0.735 12.37775 ? 227 VAL A CB  1 
ATOM   1664 C CB  B VAL A 1 146 ? 26.94020  7.56289   -12.41796 0.265 13.33311 ? 227 VAL A CB  1 
ATOM   1665 C CG1 A VAL A 1 146 ? 25.93194  7.83792   -11.67525 0.735 15.04418 ? 227 VAL A CG1 1 
ATOM   1666 C CG1 B VAL A 1 146 ? 25.62496  8.01954   -11.80215 0.265 16.51270 ? 227 VAL A CG1 1 
ATOM   1667 C CG2 A VAL A 1 146 ? 27.00158  7.54720   -13.93857 0.735 14.78701 ? 227 VAL A CG2 1 
ATOM   1668 C CG2 B VAL A 1 146 ? 26.83829  7.48687   -13.93235 0.265 14.75944 ? 227 VAL A CG2 1 
ATOM   1669 N N   . GLN A 1 147 ? 28.52370  9.36596   -9.76682  1.000 13.70042 ? 228 GLN A N   1 
ATOM   1670 C CA  . GLN A 1 147 ? 29.03266  9.30293   -8.39943  1.000 13.65820 ? 228 GLN A CA  1 
ATOM   1671 C C   . GLN A 1 147 ? 28.29760  8.26946   -7.54568  1.000 12.13299 ? 228 GLN A C   1 
ATOM   1672 O O   . GLN A 1 147 ? 28.92241  7.58817   -6.72639  1.000 13.72875 ? 228 GLN A O   1 
ATOM   1673 C CB  . GLN A 1 147 ? 29.03744  10.69479  -7.76475  1.000 15.42557 ? 228 GLN A CB  1 
ATOM   1674 C CG  . GLN A 1 147 ? 30.15305  11.61949  -8.28084  1.000 20.51581 ? 228 GLN A CG  1 
ATOM   1675 C CD  . GLN A 1 147 ? 31.46863  10.90689  -8.56121  1.000 18.58939 ? 228 GLN A CD  1 
ATOM   1676 O OE1 . GLN A 1 147 ? 32.26499  10.68457  -7.64549  1.000 25.20054 ? 228 GLN A OE1 1 
ATOM   1677 N NE2 . GLN A 1 147 ? 31.72115  10.58097  -9.82590  1.000 22.02339 ? 228 GLN A NE2 1 
ATOM   1678 N N   . LYS A 1 148 ? 26.98589  8.12298   -7.73162  1.000 13.41854 ? 229 LYS A N   1 
ATOM   1679 C CA  . LYS A 1 148 ? 26.26831  7.09857   -6.97968  1.000 14.61497 ? 229 LYS A CA  1 
ATOM   1680 C C   . LYS A 1 148 ? 26.80667  5.70628   -7.30107  1.000 12.10307 ? 229 LYS A C   1 
ATOM   1681 O O   . LYS A 1 148 ? 26.88544  4.83849   -6.41584  1.000 13.35545 ? 229 LYS A O   1 
ATOM   1682 C CB  . LYS A 1 148 ? 24.77070  7.17307   -7.26510  1.000 14.12937 ? 229 LYS A CB  1 
ATOM   1683 C CG  . LYS A 1 148 ? 23.96292  6.22407   -6.39456  1.000 19.89753 ? 229 LYS A CG  1 
ATOM   1684 C CD  . LYS A 1 148 ? 22.47722  6.51721   -6.46489  1.000 21.32503 ? 229 LYS A CD  1 
ATOM   1685 C CE  . LYS A 1 148 ? 21.67759  5.47607   -5.70238  1.000 22.99832 ? 229 LYS A CE  1 
ATOM   1686 N NZ  . LYS A 1 148 ? 20.22434  5.78981   -5.71487  1.000 23.74475 ? 229 LYS A NZ  1 
ATOM   1687 N N   . CYS A 1 149 ? 27.20221  5.47877   -8.55789  1.000 11.15106 ? 230 CYS A N   1 
ATOM   1688 C CA  . CYS A 1 149 ? 27.77174  4.18684   -8.92953  1.000 10.93588 ? 230 CYS A CA  1 
ATOM   1689 C C   . CYS A 1 149 ? 29.16781  4.00837   -8.34956  1.000 11.34312 ? 230 CYS A C   1 
ATOM   1690 O O   . CYS A 1 149 ? 29.49583  2.94020   -7.82497  1.000 11.65738 ? 230 CYS A O   1 
ATOM   1691 C CB  . CYS A 1 149 ? 27.78236  4.01574   -10.44432 1.000 11.94371 ? 230 CYS A CB  1 
ATOM   1692 S SG  . CYS A 1 149 ? 26.13181  4.00091   -11.19556 1.000 12.46277 ? 230 CYS A SG  1 
ATOM   1693 N N   . ALA A 1 150 ? 30.01492  5.03299   -8.45031  1.000 11.98801 ? 231 ALA A N   1 
ATOM   1694 C CA  . ALA A 1 150 ? 31.33994  4.95056   -7.84700  1.000 12.43079 ? 231 ALA A CA  1 
ATOM   1695 C C   . ALA A 1 150 ? 31.23366  4.64738   -6.36170  1.000 12.58864 ? 231 ALA A C   1 
ATOM   1696 O O   . ALA A 1 150 ? 31.98967  3.82915   -5.82756  1.000 14.25079 ? 231 ALA A O   1 
ATOM   1697 C CB  . ALA A 1 150 ? 32.10950  6.25725   -8.07062  1.000 13.49293 ? 231 ALA A CB  1 
ATOM   1698 N N   . ASN A 1 151 ? 30.29535  5.29089   -5.68319  1.000 12.58218 ? 232 ASN A N   1 
ATOM   1699 C CA  . ASN A 1 151 ? 30.14774  5.07983   -4.25293  1.000 14.48456 ? 232 ASN A CA  1 
ATOM   1700 C C   . ASN A 1 151 ? 29.51772  3.73703   -3.92940  1.000 12.16341 ? 232 ASN A C   1 
ATOM   1701 O O   . ASN A 1 151 ? 29.69334  3.24740   -2.80749  1.000 13.79490 ? 232 ASN A O   1 
ATOM   1702 C CB  . ASN A 1 151 ? 29.33883  6.22259   -3.65050  1.000 17.27754 ? 232 ASN A CB  1 
ATOM   1703 C CG  . ASN A 1 151 ? 30.13245  7.51232   -3.59748  1.000 20.19140 ? 232 ASN A CG  1 
ATOM   1704 O OD1 . ASN A 1 151 ? 31.36526  7.48785   -3.57671  1.000 23.10411 ? 232 ASN A OD1 1 
ATOM   1705 N ND2 . ASN A 1 151 ? 29.43396  8.64410   -3.59136  1.000 30.84142 ? 232 ASN A ND2 1 
ATOM   1706 N N   . ALA A 1 152 ? 28.79541  3.13943   -4.87570  1.000 12.47824 ? 233 ALA A N   1 
ATOM   1707 C CA  . ALA A 1 152 ? 28.16758  1.83761   -4.69653  1.000 12.10895 ? 233 ALA A CA  1 
ATOM   1708 C C   . ALA A 1 152 ? 29.06106  0.67689   -5.10162  1.000 10.93794 ? 233 ALA A C   1 
ATOM   1709 O O   . ALA A 1 152 ? 28.72065  -0.46679  -4.78941  1.000 11.31652 ? 233 ALA A O   1 
ATOM   1710 C CB  . ALA A 1 152 ? 26.87361  1.77063   -5.51244  1.000 12.97639 ? 233 ALA A CB  1 
ATOM   1711 N N   . LYS A 1 153 ? 30.19211  0.93380   -5.76389  1.000 12.05933 ? 234 LYS A N   1 
ATOM   1712 C CA  . LYS A 1 153 ? 30.97722  -0.13265  -6.37737  1.000 11.62740 ? 234 LYS A CA  1 
ATOM   1713 C C   . LYS A 1 153 ? 31.31433  -1.24924  -5.39593  1.000 10.89726 ? 234 LYS A C   1 
ATOM   1714 O O   . LYS A 1 153 ? 31.05233  -2.42968  -5.67296  1.000 11.37866 ? 234 LYS A O   1 
ATOM   1715 C CB  . LYS A 1 153 ? 32.24637  0.45254   -6.99374  1.000 12.60506 ? 234 LYS A CB  1 
ATOM   1716 C CG  . LYS A 1 153 ? 33.09865  -0.59641  -7.68972  1.000 13.42073 ? 234 LYS A CG  1 
ATOM   1717 C CD  . LYS A 1 153 ? 34.36335  0.00022   -8.27146  1.000 16.39259 ? 234 LYS A CD  1 
ATOM   1718 C CE  . LYS A 1 153 ? 35.36619  -1.09273  -8.62382  1.000 24.43052 ? 234 LYS A CE  1 
ATOM   1719 N NZ  . LYS A 1 153 ? 36.18872  -0.74041  -9.81787  1.000 29.02460 ? 234 LYS A NZ  1 
ATOM   1720 N N   . THR A 1 154 ? 31.91159  -0.91198  -4.24827  1.000 11.87348 ? 235 THR A N   1 
ATOM   1721 C CA  . THR A 1 154 ? 32.32358  -1.99168  -3.35407  1.000 12.15049 ? 235 THR A CA  1 
ATOM   1722 C C   . THR A 1 154 ? 31.12629  -2.76599  -2.81393  1.000 10.98040 ? 235 THR A C   1 
ATOM   1723 O O   . THR A 1 154 ? 31.22065  -3.98851  -2.62709  1.000 11.24702 ? 235 THR A O   1 
ATOM   1724 C CB  . THR A 1 154 ? 33.20199  -1.49219  -2.20643  1.000 14.06162 ? 235 THR A CB  1 
ATOM   1725 O OG1 . THR A 1 154 ? 32.49332  -0.50828  -1.46014  1.000 15.14635 ? 235 THR A OG1 1 
ATOM   1726 C CG2 . THR A 1 154 ? 34.49558  -0.89317  -2.72472  1.000 15.87955 ? 235 THR A CG2 1 
ATOM   1727 N N   . THR A 1 155 ? 30.00211  -2.08310  -2.58329  1.000 11.89765 ? 236 THR A N   1 
ATOM   1728 C CA  . THR A 1 155 ? 28.80833  -2.74753  -2.07565  1.000 11.59784 ? 236 THR A CA  1 
ATOM   1729 C C   . THR A 1 155 ? 28.19328  -3.65129  -3.12977  1.000 10.64324 ? 236 THR A C   1 
ATOM   1730 O O   . THR A 1 155 ? 27.81885  -4.78938  -2.82848  1.000 10.56602 ? 236 THR A O   1 
ATOM   1731 C CB  . THR A 1 155 ? 27.78603  -1.71677  -1.60419  1.000 12.24217 ? 236 THR A CB  1 
ATOM   1732 O OG1 . THR A 1 155 ? 28.36571  -0.90009  -0.58062  1.000 13.02449 ? 236 THR A OG1 1 
ATOM   1733 C CG2 . THR A 1 155 ? 26.54871  -2.39727  -1.05416  1.000 12.90564 ? 236 THR A CG2 1 
ATOM   1734 N N   . TYR A 1 156 ? 28.09022  -3.17586  -4.37467  1.000 10.91706 ? 237 TYR A N   1 
ATOM   1735 C CA  . TYR A 1 156 ? 27.57617  -4.03174  -5.43658  1.000 11.21597 ? 237 TYR A CA  1 
ATOM   1736 C C   . TYR A 1 156 ? 28.42319  -5.29050  -5.56245  1.000 10.58991 ? 237 TYR A C   1 
ATOM   1737 O O   . TYR A 1 156 ? 27.89928  -6.40541  -5.66976  1.000 9.92483  ? 237 TYR A O   1 
ATOM   1738 C CB  . TYR A 1 156 ? 27.59569  -3.28123  -6.76311  1.000 10.77992 ? 237 TYR A CB  1 
ATOM   1739 C CG  . TYR A 1 156 ? 26.44754  -2.33735  -7.05082  1.000 10.32857 ? 237 TYR A CG  1 
ATOM   1740 C CD1 . TYR A 1 156 ? 25.57235  -1.90512  -6.06032  1.000 10.84675 ? 237 TYR A CD1 1 
ATOM   1741 C CD2 . TYR A 1 156 ? 26.26937  -1.86396  -8.33892  1.000 10.60896 ? 237 TYR A CD2 1 
ATOM   1742 C CE1 . TYR A 1 156 ? 24.53035  -1.02064  -6.36758  1.000 10.68529 ? 237 TYR A CE1 1 
ATOM   1743 C CE2 . TYR A 1 156 ? 25.25387  -0.99275  -8.64967  1.000 11.15689 ? 237 TYR A CE2 1 
ATOM   1744 C CZ  . TYR A 1 156 ? 24.39366  -0.56830  -7.67098  1.000 10.65271 ? 237 TYR A CZ  1 
ATOM   1745 O OH  . TYR A 1 156 ? 23.37412  0.31324   -7.99799  1.000 11.94138 ? 237 TYR A OH  1 
ATOM   1746 N N   . LEU A 1 157 ? 29.74573  -5.13239  -5.57593  1.000 10.43743 ? 238 LEU A N   1 
ATOM   1747 C CA  . LEU A 1 157 ? 30.61614  -6.29357  -5.73246  1.000 10.86916 ? 238 LEU A CA  1 
ATOM   1748 C C   . LEU A 1 157 ? 30.49406  -7.24950  -4.54921  1.000 10.30407 ? 238 LEU A C   1 
ATOM   1749 O O   . LEU A 1 157 ? 30.40224  -8.46930  -4.73552  1.000 10.34728 ? 238 LEU A O   1 
ATOM   1750 C CB  . LEU A 1 157 ? 32.05812  -5.82198  -5.90679  1.000 12.05973 ? 238 LEU A CB  1 
ATOM   1751 C CG  . LEU A 1 157 ? 32.32989  -5.08470  -7.21842  1.000 13.25117 ? 238 LEU A CG  1 
ATOM   1752 C CD1 . LEU A 1 157 ? 33.72011  -4.47799  -7.20371  1.000 14.97058 ? 238 LEU A CD1 1 
ATOM   1753 C CD2 . LEU A 1 157 ? 32.16811  -6.02415  -8.40126  1.000 14.62424 ? 238 LEU A CD2 1 
ATOM   1754 N N   . ALA A 1 158 ? 30.46912  -6.72215  -3.32491  1.000 10.44123 ? 239 ALA A N   1 
ATOM   1755 C CA  . ALA A 1 158 ? 30.37186  -7.58838  -2.15668  1.000 10.41274 ? 239 ALA A CA  1 
ATOM   1756 C C   . ALA A 1 158 ? 29.01583  -8.27687  -2.10236  1.000 10.00803 ? 239 ALA A C   1 
ATOM   1757 O O   . ALA A 1 158 ? 28.92121  -9.44968  -1.71901  1.000 10.46913 ? 239 ALA A O   1 
ATOM   1758 C CB  . ALA A 1 158 ? 30.56634  -6.76477  -0.88901  1.000 11.44477 ? 239 ALA A CB  1 
ATOM   1759 N N   . SER A 1 159 ? 27.94959  -7.55074  -2.44257  1.000 9.33187  ? 240 SER A N   1 
ATOM   1760 C CA  . SER A 1 159 ? 26.60587  -8.10629  -2.35156  1.000 10.06234 ? 240 SER A CA  1 
ATOM   1761 C C   . SER A 1 159 ? 26.36634  -9.14998  -3.43342  1.000 9.41429  ? 240 SER A C   1 
ATOM   1762 O O   . SER A 1 159 ? 25.84978  -10.24126 -3.15314  1.000 10.02161 ? 240 SER A O   1 
ATOM   1763 C CB  . SER A 1 159 ? 25.58939  -6.97075  -2.42180  1.000 10.44409 ? 240 SER A CB  1 
ATOM   1764 O OG  . SER A 1 159 ? 25.65383  -6.16275  -1.25322  1.000 12.62696 ? 240 SER A OG  1 
ATOM   1765 N N   . VAL A 1 160 ? 26.75254  -8.84880  -4.67223  1.000 10.33369 ? 241 VAL A N   1 
ATOM   1766 C CA  . VAL A 1 160 ? 26.65726  -9.85486  -5.72044  1.000 10.75212 ? 241 VAL A CA  1 
ATOM   1767 C C   . VAL A 1 160 ? 27.48604  -11.08014 -5.35538  1.000 9.76715  ? 241 VAL A C   1 
ATOM   1768 O O   . VAL A 1 160 ? 27.04150  -12.22184 -5.53281  1.000 9.89312  ? 241 VAL A O   1 
ATOM   1769 C CB  . VAL A 1 160 ? 27.03821  -9.26505  -7.09091  1.000 9.86285  ? 241 VAL A CB  1 
ATOM   1770 C CG1 . VAL A 1 160 ? 27.22817  -10.36603 -8.13199  1.000 11.51194 ? 241 VAL A CG1 1 
ATOM   1771 C CG2 . VAL A 1 160 ? 25.99057  -8.25563  -7.54367  1.000 10.99265 ? 241 VAL A CG2 1 
ATOM   1772 N N   . ASN A 1 161 ? 28.69245  -10.86805 -4.81707  1.000 9.76707  ? 242 ASN A N   1 
ATOM   1773 C CA  . ASN A 1 161 ? 29.50241  -12.00125 -4.38962  1.000 9.99427  ? 242 ASN A CA  1 
ATOM   1774 C C   . ASN A 1 161 ? 28.77835  -12.85103 -3.35642  1.000 9.99162  ? 242 ASN A C   1 
ATOM   1775 O O   . ASN A 1 161 ? 28.83559  -14.08466 -3.40903  1.000 9.89994  ? 242 ASN A O   1 
ATOM   1776 C CB  . ASN A 1 161 ? 30.82410  -11.51911 -3.81852  1.000 10.15447 ? 242 ASN A CB  1 
ATOM   1777 C CG  . ASN A 1 161 ? 31.67634  -12.67558 -3.38440  1.000 10.91921 ? 242 ASN A CG  1 
ATOM   1778 O OD1 . ASN A 1 161 ? 32.17865  -13.42536 -4.21931  1.000 11.99406 ? 242 ASN A OD1 1 
ATOM   1779 N ND2 . ASN A 1 161 ? 31.77736  -12.88918 -2.07941  1.000 12.41585 ? 242 ASN A ND2 1 
ATOM   1780 N N   . TYR A 1 162 ? 28.13376  -12.20819 -2.38084  1.000 9.82594  ? 243 TYR A N   1 
ATOM   1781 C CA  . TYR A 1 162 ? 27.42264  -12.94546 -1.34930  1.000 10.19107 ? 243 TYR A CA  1 
ATOM   1782 C C   . TYR A 1 162 ? 26.30327  -13.77196 -1.95803  1.000 8.97079  ? 243 TYR A C   1 
ATOM   1783 O O   . TYR A 1 162 ? 26.08171  -14.92641 -1.56950  1.000 9.76032  ? 243 TYR A O   1 
ATOM   1784 C CB  . TYR A 1 162 ? 26.87488  -11.97792 -0.29760  1.000 10.76076 ? 243 TYR A CB  1 
ATOM   1785 C CG  . TYR A 1 162 ? 26.37134  -12.68041 0.93543   1.000 9.99289  ? 243 TYR A CG  1 
ATOM   1786 C CD1 . TYR A 1 162 ? 25.05572  -13.12915 1.02107   1.000 9.65981  ? 243 TYR A CD1 1 
ATOM   1787 C CD2 . TYR A 1 162 ? 27.21610  -12.91300 2.01097   1.000 10.14672 ? 243 TYR A CD2 1 
ATOM   1788 C CE1 . TYR A 1 162 ? 24.60347  -13.78950 2.14806   1.000 11.60869 ? 243 TYR A CE1 1 
ATOM   1789 C CE2 . TYR A 1 162 ? 26.77788  -13.56922 3.14170   1.000 11.89916 ? 243 TYR A CE2 1 
ATOM   1790 C CZ  . TYR A 1 162 ? 25.46879  -14.00536 3.21072   1.000 11.62791 ? 243 TYR A CZ  1 
ATOM   1791 O OH  . TYR A 1 162 ? 25.01498  -14.65742 4.33647   1.000 13.48195 ? 243 TYR A OH  1 
ATOM   1792 N N   . ALA A 1 163 ? 25.56459  -13.18084 -2.89185  1.000 8.71345  ? 244 ALA A N   1 
ATOM   1793 C CA  . ALA A 1 163 ? 24.49477  -13.90198 -3.56665  1.000 9.08883  ? 244 ALA A CA  1 
ATOM   1794 C C   . ALA A 1 163 ? 25.03288  -15.10786 -4.31670  1.000 8.89541  ? 244 ALA A C   1 
ATOM   1795 O O   . ALA A 1 163 ? 24.49943  -16.21544 -4.18773  1.000 9.19581  ? 244 ALA A O   1 
ATOM   1796 C CB  . ALA A 1 163 ? 23.76051  -12.96556 -4.51717  1.000 9.95729  ? 244 ALA A CB  1 
ATOM   1797 N N   . LEU A 1 164 ? 26.06363  -14.91287 -5.13308  1.000 9.07882  ? 245 LEU A N   1 
ATOM   1798 C CA  . LEU A 1 164 ? 26.60128  -16.02509 -5.90748  1.000 9.88449  ? 245 LEU A CA  1 
ATOM   1799 C C   . LEU A 1 164 ? 27.11632  -17.12439 -4.98884  1.000 9.12739  ? 245 LEU A C   1 
ATOM   1800 O O   . LEU A 1 164 ? 26.84523  -18.31199 -5.20124  1.000 10.13559 ? 245 LEU A O   1 
ATOM   1801 C CB  . LEU A 1 164 ? 27.74691  -15.52146 -6.77842  1.000 10.07542 ? 245 LEU A CB  1 
ATOM   1802 C CG  . LEU A 1 164 ? 27.37749  -14.54914 -7.89079  1.000 9.84566  ? 245 LEU A CG  1 
ATOM   1803 C CD1 . LEU A 1 164 ? 28.64196  -13.93309 -8.41921  1.000 11.89380 ? 245 LEU A CD1 1 
ATOM   1804 C CD2 . LEU A 1 164 ? 26.59366  -15.21594 -9.01363  1.000 11.75144 ? 245 LEU A CD2 1 
ATOM   1805 N N   . THR A 1 165 ? 27.89677  -16.74700 -3.97711  1.000 9.64665  ? 246 THR A N   1 
ATOM   1806 C CA  A THR A 1 165 ? 28.53368  -17.72454 -3.09549  0.865 10.10569 ? 246 THR A CA  1 
ATOM   1807 C CA  B THR A 1 165 ? 28.52368  -17.77342 -3.15774  0.135 10.08815 ? 246 THR A CA  1 
ATOM   1808 C C   . THR A 1 165 ? 27.48685  -18.55164 -2.35925  1.000 10.56555 ? 246 THR A C   1 
ATOM   1809 O O   . THR A 1 165 ? 27.60849  -19.77596 -2.22432  1.000 10.99005 ? 246 THR A O   1 
ATOM   1810 C CB  A THR A 1 165 ? 29.43442  -16.97176 -2.09910  0.865 11.55974 ? 246 THR A CB  1 
ATOM   1811 C CB  B THR A 1 165 ? 29.60714  -17.18330 -2.25569  0.135 11.66350 ? 246 THR A CB  1 
ATOM   1812 O OG1 A THR A 1 165 ? 30.53885  -16.37823 -2.79624  0.865 10.12450 ? 246 THR A OG1 1 
ATOM   1813 O OG1 B THR A 1 165 ? 30.27059  -18.24140 -1.54964  0.135 14.37544 ? 246 THR A OG1 1 
ATOM   1814 C CG2 A THR A 1 165 ? 29.96858  -17.88869 -1.01038  0.865 11.78280 ? 246 THR A CG2 1 
ATOM   1815 C CG2 B THR A 1 165 ? 28.99190  -16.25962 -1.25362  0.135 9.56587  ? 246 THR A CG2 1 
ATOM   1816 N N   . ASN A 1 166 ? 26.43283  -17.89347 -1.87483  1.000 9.38588  ? 247 ASN A N   1 
ATOM   1817 C CA  . ASN A 1 166 ? 25.46930  -18.60247 -1.05114  1.000 10.07358 ? 247 ASN A CA  1 
ATOM   1818 C C   . ASN A 1 166 ? 24.37307  -19.29496 -1.83638  1.000 10.11203 ? 247 ASN A C   1 
ATOM   1819 O O   . ASN A 1 166 ? 23.94236  -20.37580 -1.43078  1.000 10.50151 ? 247 ASN A O   1 
ATOM   1820 C CB  . ASN A 1 166 ? 24.96701  -17.68807 0.05298   1.000 10.97301 ? 247 ASN A CB  1 
ATOM   1821 C CG  . ASN A 1 166 ? 26.02208  -17.50876 1.10429   1.000 11.30522 ? 247 ASN A CG  1 
ATOM   1822 O OD1 . ASN A 1 166 ? 26.28041  -18.42691 1.87461   1.000 13.56729 ? 247 ASN A OD1 1 
ATOM   1823 N ND2 . ASN A 1 166 ? 26.70496  -16.36993 1.09341   1.000 12.64931 ? 247 ASN A ND2 1 
ATOM   1824 N N   . LEU A 1 167 ? 23.92290  -18.73367 -2.96030  1.000 9.61106  ? 248 LEU A N   1 
ATOM   1825 C CA  . LEU A 1 167 ? 22.99743  -19.48034 -3.80476  1.000 9.35325  ? 248 LEU A CA  1 
ATOM   1826 C C   . LEU A 1 167 ? 23.65987  -20.71914 -4.39814  1.000 9.22895  ? 248 LEU A C   1 
ATOM   1827 O O   . LEU A 1 167 ? 22.98555  -21.72882 -4.62920  1.000 10.12827 ? 248 LEU A O   1 
ATOM   1828 C CB  . LEU A 1 167 ? 22.42558  -18.57079 -4.89304  1.000 9.24286  ? 248 LEU A CB  1 
ATOM   1829 C CG  . LEU A 1 167 ? 21.50571  -17.46695 -4.37561  1.000 10.19904 ? 248 LEU A CG  1 
ATOM   1830 C CD1 . LEU A 1 167 ? 21.27174  -16.40853 -5.44376  1.000 11.63106 ? 248 LEU A CD1 1 
ATOM   1831 C CD2 . LEU A 1 167 ? 20.17678  -18.02103 -3.88003  1.000 12.58949 ? 248 LEU A CD2 1 
ATOM   1832 N N   . ALA A 1 168 ? 24.97388  -20.68049 -4.62184  1.000 9.49110  ? 249 ALA A N   1 
ATOM   1833 C CA  . ALA A 1 168 ? 25.65716  -21.86611 -5.13009  1.000 9.58428  ? 249 ALA A CA  1 
ATOM   1834 C C   . ALA A 1 168 ? 25.56083  -23.03005 -4.15371  1.000 9.29854  ? 249 ALA A C   1 
ATOM   1835 O O   . ALA A 1 168 ? 25.53224  -24.19583 -4.56864  1.000 10.22233 ? 249 ALA A O   1 
ATOM   1836 C CB  . ALA A 1 168 ? 27.12378  -21.55718 -5.44103  1.000 11.85993 ? 249 ALA A CB  1 
ATOM   1837 N N   . LYS A 1 169 ? 25.50337  -22.73861 -2.85263  1.000 10.58734 ? 250 LYS A N   1 
ATOM   1838 C CA  . LYS A 1 169 ? 25.48302  -23.78808 -1.84284  1.000 10.56883 ? 250 LYS A CA  1 
ATOM   1839 C C   . LYS A 1 169 ? 24.19303  -24.57895 -1.87520  1.000 10.45693 ? 250 LYS A C   1 
ATOM   1840 O O   . LYS A 1 169 ? 24.15292  -25.69309 -1.33346  1.000 12.05330 ? 250 LYS A O   1 
ATOM   1841 C CB  . LYS A 1 169 ? 25.65453  -23.19071 -0.44887  1.000 11.14591 ? 250 LYS A CB  1 
ATOM   1842 C CG  . LYS A 1 169 ? 26.99412  -22.54089 -0.21554  1.000 11.13133 ? 250 LYS A CG  1 
ATOM   1843 C CD  . LYS A 1 169 ? 27.03736  -21.85469 1.13537   1.000 12.77960 ? 250 LYS A CD  1 
ATOM   1844 C CE  . LYS A 1 169 ? 28.37905  -21.16177 1.32986   1.000 14.45784 ? 250 LYS A CE  1 
ATOM   1845 N NZ  . LYS A 1 169 ? 28.41431  -20.28554 2.53066   1.000 14.23203 ? 250 LYS A NZ  1 
ATOM   1846 N N   . VAL A 1 170 ? 23.13622  -24.03050 -2.46790  1.000 10.87861 ? 251 VAL A N   1 
ATOM   1847 C CA  . VAL A 1 170 ? 21.88529  -24.74659 -2.65827  1.000 11.27228 ? 251 VAL A CA  1 
ATOM   1848 C C   . VAL A 1 170 ? 21.64900  -25.07579 -4.13092  1.000 10.47810 ? 251 VAL A C   1 
ATOM   1849 O O   . VAL A 1 170 ? 20.52445  -25.38947 -4.52121  1.000 11.18577 ? 251 VAL A O   1 
ATOM   1850 C CB  . VAL A 1 170 ? 20.68865  -24.05414 -1.98020  1.000 11.33833 ? 251 VAL A CB  1 
ATOM   1851 C CG1 . VAL A 1 170 ? 20.79589  -24.21952 -0.47800  1.000 14.54207 ? 251 VAL A CG1 1 
ATOM   1852 C CG2 . VAL A 1 170 ? 20.62323  -22.57356 -2.33852  1.000 12.50645 ? 251 VAL A CG2 1 
ATOM   1853 N N   . GLY A 1 171 ? 22.70407  -25.04188 -4.94353  1.000 10.05566 ? 252 GLY A N   1 
ATOM   1854 C CA  . GLY A 1 171 ? 22.65666  -25.56982 -6.29599  1.000 10.90806 ? 252 GLY A CA  1 
ATOM   1855 C C   . GLY A 1 171 ? 21.84251  -24.77022 -7.29184  1.000 10.19074 ? 252 GLY A C   1 
ATOM   1856 O O   . GLY A 1 171 ? 21.36197  -25.33402 -8.27964  1.000 9.63200  ? 252 GLY A O   1 
ATOM   1857 N N   . VAL A 1 172 ? 21.68236  -23.46994 -7.05983  1.000 9.71191  ? 253 VAL A N   1 
ATOM   1858 C CA  . VAL A 1 172 ? 20.97442  -22.60245 -7.98990  1.000 9.01401  ? 253 VAL A CA  1 
ATOM   1859 C C   . VAL A 1 172 ? 21.84276  -22.33226 -9.20904  1.000 8.57026  ? 253 VAL A C   1 
ATOM   1860 O O   . VAL A 1 172 ? 23.00766  -21.94870 -9.08236  1.000 9.09444  ? 253 VAL A O   1 
ATOM   1861 C CB  . VAL A 1 172 ? 20.61708  -21.28677 -7.28112  1.000 10.33144 ? 253 VAL A CB  1 
ATOM   1862 C CG1 . VAL A 1 172 ? 19.97774  -20.29703 -8.24025  1.000 9.31721  ? 253 VAL A CG1 1 
ATOM   1863 C CG2 . VAL A 1 172 ? 19.71210  -21.55026 -6.07490  1.000 10.49648 ? 253 VAL A CG2 1 
ATOM   1864 N N   . TYR A 1 173 ? 21.26661  -22.49448 -10.39068 1.000 8.34118  ? 254 TYR A N   1 
ATOM   1865 C CA  . TYR A 1 173 ? 21.95570  -22.13864 -11.62270 1.000 8.75744  ? 254 TYR A CA  1 
ATOM   1866 C C   . TYR A 1 173 ? 21.80730  -20.64322 -11.86001 1.000 9.09230  ? 254 TYR A C   1 
ATOM   1867 O O   . TYR A 1 173 ? 20.68665  -20.11987 -11.88086 1.000 9.86856  ? 254 TYR A O   1 
ATOM   1868 C CB  . TYR A 1 173 ? 21.36687  -22.93919 -12.77690 1.000 9.14200  ? 254 TYR A CB  1 
ATOM   1869 C CG  . TYR A 1 173 ? 21.80744  -24.37983 -12.70385 1.000 8.77879  ? 254 TYR A CG  1 
ATOM   1870 C CD1 . TYR A 1 173 ? 23.03987  -24.75496 -13.21675 1.000 9.60144  ? 254 TYR A CD1 1 
ATOM   1871 C CD2 . TYR A 1 173 ? 21.02755  -25.35755 -12.10245 1.000 10.10010 ? 254 TYR A CD2 1 
ATOM   1872 C CE1 . TYR A 1 173 ? 23.49147  -26.06105 -13.13526 1.000 11.11276 ? 254 TYR A CE1 1 
ATOM   1873 C CE2 . TYR A 1 173 ? 21.47650  -26.67767 -12.01793 1.000 11.47662 ? 254 TYR A CE2 1 
ATOM   1874 C CZ  . TYR A 1 173 ? 22.71062  -27.00176 -12.52923 1.000 10.44515 ? 254 TYR A CZ  1 
ATOM   1875 O OH  . TYR A 1 173 ? 23.17585  -28.29661 -12.47931 1.000 11.97409 ? 254 TYR A OH  1 
ATOM   1876 N N   . MET A 1 174 ? 22.92907  -19.95267 -12.04699 1.000 8.88298  ? 255 MET A N   1 
ATOM   1877 C CA  A MET A 1 174 ? 22.95443  -18.49809 -12.00321 0.652 8.05781  ? 255 MET A CA  1 
ATOM   1878 C CA  B MET A 1 174 ? 22.93082  -18.50011 -12.01692 0.348 8.09139  ? 255 MET A CA  1 
ATOM   1879 C C   . MET A 1 174 ? 23.52143  -17.89951 -13.27938 1.000 8.77550  ? 255 MET A C   1 
ATOM   1880 O O   . MET A 1 174 ? 24.53481  -18.37547 -13.80916 1.000 9.20372  ? 255 MET A O   1 
ATOM   1881 C CB  A MET A 1 174 ? 23.79505  -18.04129 -10.82465 0.652 10.00035 ? 255 MET A CB  1 
ATOM   1882 C CB  B MET A 1 174 ? 23.67321  -17.98111 -10.79586 0.348 10.13467 ? 255 MET A CB  1 
ATOM   1883 C CG  A MET A 1 174 ? 23.19256  -18.45524 -9.49640  0.652 8.35314  ? 255 MET A CG  1 
ATOM   1884 C CG  B MET A 1 174 ? 22.88986  -18.18864 -9.51950  0.348 10.96170 ? 255 MET A CG  1 
ATOM   1885 S SD  A MET A 1 174 ? 24.28313  -18.15800 -8.09112  0.652 9.11031  ? 255 MET A SD  1 
ATOM   1886 S SD  B MET A 1 174 ? 23.87926  -17.91130 -8.05440  0.348 10.07109 ? 255 MET A SD  1 
ATOM   1887 C CE  A MET A 1 174 ? 25.33726  -19.61605 -8.11776  0.652 9.58475  ? 255 MET A CE  1 
ATOM   1888 C CE  B MET A 1 174 ? 25.12791  -19.18478 -8.21780  0.348 12.89090 ? 255 MET A CE  1 
ATOM   1889 N N   . TYR A 1 175 ? 22.87810  -16.82811 -13.73956 1.000 8.94959  ? 256 TYR A N   1 
ATOM   1890 C CA  . TYR A 1 175 ? 23.35109  -16.02688 -14.85836 1.000 8.73719  ? 256 TYR A CA  1 
ATOM   1891 C C   . TYR A 1 175 ? 23.42817  -14.59208 -14.35335 1.000 9.07449  ? 256 TYR A C   1 
ATOM   1892 O O   . TYR A 1 175 ? 22.40628  -14.01949 -13.95453 1.000 9.45102  ? 256 TYR A O   1 
ATOM   1893 C CB  . TYR A 1 175 ? 22.40438  -16.13728 -16.06243 1.000 9.27785  ? 256 TYR A CB  1 
ATOM   1894 C CG  . TYR A 1 175 ? 22.32549  -17.54252 -16.62867 1.000 8.51918  ? 256 TYR A CG  1 
ATOM   1895 C CD1 . TYR A 1 175 ? 21.43928  -18.47787 -16.10935 1.000 9.44545  ? 256 TYR A CD1 1 
ATOM   1896 C CD2 . TYR A 1 175 ? 23.15372  -17.93127 -17.67494 1.000 9.39352  ? 256 TYR A CD2 1 
ATOM   1897 C CE1 . TYR A 1 175 ? 21.37690  -19.75522 -16.62538 1.000 9.95436  ? 256 TYR A CE1 1 
ATOM   1898 C CE2 . TYR A 1 175 ? 23.09347  -19.21274 -18.19559 1.000 9.64674  ? 256 TYR A CE2 1 
ATOM   1899 C CZ  . TYR A 1 175 ? 22.18737  -20.12178 -17.66264 1.000 9.59367  ? 256 TYR A CZ  1 
ATOM   1900 O OH  . TYR A 1 175 ? 22.10050  -21.41164 -18.16291 1.000 10.12071 ? 256 TYR A OH  1 
ATOM   1901 N N   . MET A 1 176 ? 24.63004  -14.02032 -14.32124 1.000 8.91751  ? 257 MET A N   1 
ATOM   1902 C CA  A MET A 1 176 ? 24.79628  -12.63752 -13.88689 0.527 9.42843  ? 257 MET A CA  1 
ATOM   1903 C CA  B MET A 1 176 ? 24.74716  -12.64691 -13.86980 0.473 9.37479  ? 257 MET A CA  1 
ATOM   1904 C C   . MET A 1 176 ? 24.27378  -11.70490 -14.96161 1.000 8.37578  ? 257 MET A C   1 
ATOM   1905 O O   . MET A 1 176 ? 24.58175  -11.88016 -16.14298 1.000 8.92906  ? 257 MET A O   1 
ATOM   1906 C CB  A MET A 1 176 ? 26.28102  -12.28458 -13.74320 0.527 10.19274 ? 257 MET A CB  1 
ATOM   1907 C CB  B MET A 1 176 ? 26.19117  -12.32614 -13.51454 0.473 9.95111  ? 257 MET A CB  1 
ATOM   1908 C CG  A MET A 1 176 ? 27.19620  -13.22398 -12.98216 0.527 10.51089 ? 257 MET A CG  1 
ATOM   1909 C CG  B MET A 1 176 ? 26.70882  -13.07017 -12.31499 0.473 12.40866 ? 257 MET A CG  1 
ATOM   1910 S SD  A MET A 1 176 ? 28.88525  -12.54147 -12.94495 0.527 12.22001 ? 257 MET A SD  1 
ATOM   1911 S SD  B MET A 1 176 ? 28.36051  -12.50440 -11.92874 0.473 14.43769 ? 257 MET A SD  1 
ATOM   1912 C CE  A MET A 1 176 ? 29.78237  -13.97667 -12.35882 0.527 13.10798 ? 257 MET A CE  1 
ATOM   1913 C CE  B MET A 1 176 ? 29.17020  -12.84294 -13.48112 0.473 15.38004 ? 257 MET A CE  1 
ATOM   1914 N N   . ASP A 1 177 ? 23.54530  -10.66784 -14.55858 1.000 8.66851  ? 258 ASP A N   1 
ATOM   1915 C CA  . ASP A 1 177 ? 23.13858  -9.69942  -15.56405 1.000 9.11012  ? 258 ASP A CA  1 
ATOM   1916 C C   . ASP A 1 177 ? 24.35482  -9.04687  -16.21276 1.000 8.76272  ? 258 ASP A C   1 
ATOM   1917 O O   . ASP A 1 177 ? 25.30905  -8.66072  -15.53258 1.000 9.92613  ? 258 ASP A O   1 
ATOM   1918 C CB  . ASP A 1 177 ? 22.25242  -8.61394  -14.99021 1.000 9.98350  ? 258 ASP A CB  1 
ATOM   1919 C CG  . ASP A 1 177 ? 21.80096  -7.67207  -16.06424 1.000 9.73300  ? 258 ASP A CG  1 
ATOM   1920 O OD1 . ASP A 1 177 ? 20.79992  -8.01030  -16.73850 1.000 10.65905 ? 258 ASP A OD1 1 
ATOM   1921 O OD2 . ASP A 1 177 ? 22.48141  -6.64401  -16.29515 1.000 10.18278 ? 258 ASP A OD2 1 
ATOM   1922 N N   . ALA A 1 178 ? 24.30251  -8.89538  -17.53577 1.000 8.80981  ? 259 ALA A N   1 
ATOM   1923 C CA  . ALA A 1 178 ? 25.41186  -8.32483  -18.28416 1.000 8.50824  ? 259 ALA A CA  1 
ATOM   1924 C C   . ALA A 1 178 ? 24.93087  -7.28948  -19.29317 1.000 8.77683  ? 259 ALA A C   1 
ATOM   1925 O O   . ALA A 1 178 ? 25.46703  -7.17741  -20.39612 1.000 9.59303  ? 259 ALA A O   1 
ATOM   1926 C CB  . ALA A 1 178 ? 26.23527  -9.43039  -18.94067 1.000 10.53227 ? 259 ALA A CB  1 
ATOM   1927 N N   . GLY A 1 179 ? 23.91854  -6.50594  -18.93514 1.000 9.29398  ? 260 GLY A N   1 
ATOM   1928 C CA  . GLY A 1 179 ? 23.50168  -5.46790  -19.86145 1.000 9.37885  ? 260 GLY A CA  1 
ATOM   1929 C C   . GLY A 1 179 ? 23.07054  -6.02548  -21.19962 1.000 9.32183  ? 260 GLY A C   1 
ATOM   1930 O O   . GLY A 1 179 ? 22.43198  -7.07574  -21.28775 1.000 9.32480  ? 260 GLY A O   1 
ATOM   1931 N N   . HIS A 1 180 ? 23.39656  -5.30580  -22.26378 1.000 9.31348  ? 261 HIS A N   1 
ATOM   1932 C CA  . HIS A 1 180 ? 22.95521  -5.65823  -23.60153 1.000 9.21733  ? 261 HIS A CA  1 
ATOM   1933 C C   . HIS A 1 180 ? 23.97158  -5.11801  -24.59808 1.000 9.06128  ? 261 HIS A C   1 
ATOM   1934 O O   . HIS A 1 180 ? 24.94121  -4.45675  -24.21964 1.000 9.56284  ? 261 HIS A O   1 
ATOM   1935 C CB  . HIS A 1 180 ? 21.53331  -5.14956  -23.87267 1.000 9.47945  ? 261 HIS A CB  1 
ATOM   1936 C CG  . HIS A 1 180 ? 21.40764  -3.65477  -23.84917 1.000 10.49908 ? 261 HIS A CG  1 
ATOM   1937 N ND1 . HIS A 1 180 ? 21.62041  -2.85900  -24.95933 1.000 10.63039 ? 261 HIS A ND1 1 
ATOM   1938 C CD2 . HIS A 1 180 ? 21.06435  -2.81843  -22.84094 1.000 11.88459 ? 261 HIS A CD2 1 
ATOM   1939 C CE1 . HIS A 1 180 ? 21.42065  -1.59419  -24.62396 1.000 11.63058 ? 261 HIS A CE1 1 
ATOM   1940 N NE2 . HIS A 1 180 ? 21.08395  -1.54350  -23.34573 1.000 12.38781 ? 261 HIS A NE2 1 
ATOM   1941 N N   . ALA A 1 181 ? 23.74222  -5.40859  -25.88317 1.000 10.03481 ? 262 ALA A N   1 
ATOM   1942 C CA  . ALA A 1 181 ? 24.72149  -5.08103  -26.92099 1.000 9.35602  ? 262 ALA A CA  1 
ATOM   1943 C C   . ALA A 1 181 ? 25.04302  -3.59488  -26.97521 1.000 9.85798  ? 262 ALA A C   1 
ATOM   1944 O O   . ALA A 1 181 ? 26.17457  -3.21306  -27.31222 1.000 10.38210 ? 262 ALA A O   1 
ATOM   1945 C CB  . ALA A 1 181 ? 24.21101  -5.54110  -28.28897 1.000 11.53400 ? 262 ALA A CB  1 
ATOM   1946 N N   . GLY A 1 182 ? 24.06475  -2.74764  -26.69487 1.000 9.84072  ? 263 GLY A N   1 
ATOM   1947 C CA  . GLY A 1 182 ? 24.26692  -1.31609  -26.73449 1.000 10.13756 ? 263 GLY A CA  1 
ATOM   1948 C C   . GLY A 1 182 ? 24.81629  -0.73433  -25.47176 1.000 9.90361  ? 263 GLY A C   1 
ATOM   1949 O O   . GLY A 1 182 ? 25.01994  0.48363   -25.38348 1.000 10.86577 ? 263 GLY A O   1 
ATOM   1950 N N   . TRP A 1 183 ? 25.07957  -1.58350  -24.48368 1.000 10.41467 ? 264 TRP A N   1 
ATOM   1951 C CA  . TRP A 1 183 ? 25.69774  -1.17748  -23.23084 1.000 10.04475 ? 264 TRP A CA  1 
ATOM   1952 C C   . TRP A 1 183 ? 27.11522  -1.73216  -23.16499 1.000 9.77121  ? 264 TRP A C   1 
ATOM   1953 O O   . TRP A 1 183 ? 28.08262  -0.98340  -23.35342 1.000 11.20655 ? 264 TRP A O   1 
ATOM   1954 C CB  . TRP A 1 183 ? 24.84606  -1.60338  -22.03333 1.000 10.87100 ? 264 TRP A CB  1 
ATOM   1955 C CG  . TRP A 1 183 ? 25.23723  -0.98384  -20.74480 1.000 10.93113 ? 264 TRP A CG  1 
ATOM   1956 C CD1 . TRP A 1 183 ? 26.36146  -0.25419  -20.49054 1.000 11.83868 ? 264 TRP A CD1 1 
ATOM   1957 C CD2 . TRP A 1 183 ? 24.50309  -1.03678  -19.52069 1.000 10.90846 ? 264 TRP A CD2 1 
ATOM   1958 N NE1 . TRP A 1 183 ? 26.36973  0.15965   -19.17726 1.000 12.00858 ? 264 TRP A NE1 1 
ATOM   1959 C CE2 . TRP A 1 183 ? 25.23999  -0.31005  -18.56438 1.000 12.47894 ? 264 TRP A CE2 1 
ATOM   1960 C CE3 . TRP A 1 183 ? 23.29460  -1.61970  -19.13856 1.000 11.97195 ? 264 TRP A CE3 1 
ATOM   1961 C CZ2 . TRP A 1 183 ? 24.80237  -0.13855  -17.25741 1.000 12.58546 ? 264 TRP A CZ2 1 
ATOM   1962 C CZ3 . TRP A 1 183 ? 22.86313  -1.44607  -17.82394 1.000 13.50065 ? 264 TRP A CZ3 1 
ATOM   1963 C CH2 . TRP A 1 183 ? 23.62550  -0.72284  -16.90363 1.000 14.85133 ? 264 TRP A CH2 1 
ATOM   1964 N N   . LEU A 1 184 ? 27.27031  -3.03557  -22.95389 1.000 9.88200  ? 265 LEU A N   1 
ATOM   1965 C CA  . LEU A 1 184 ? 28.57900  -3.65809  -22.84714 1.000 10.56429 ? 265 LEU A CA  1 
ATOM   1966 C C   . LEU A 1 184 ? 29.07324  -4.25490  -24.15759 1.000 10.05580 ? 265 LEU A C   1 
ATOM   1967 O O   . LEU A 1 184 ? 30.23257  -4.67116  -24.21819 1.000 11.22012 ? 265 LEU A O   1 
ATOM   1968 C CB  . LEU A 1 184 ? 28.56455  -4.73117  -21.74608 1.000 9.84016  ? 265 LEU A CB  1 
ATOM   1969 C CG  . LEU A 1 184 ? 28.11928  -4.24017  -20.36999 1.000 9.93434  ? 265 LEU A CG  1 
ATOM   1970 C CD1 . LEU A 1 184 ? 28.24151  -5.36303  -19.33561 1.000 11.67442 ? 265 LEU A CD1 1 
ATOM   1971 C CD2 . LEU A 1 184 ? 28.89273  -2.98255  -19.93464 1.000 12.54484 ? 265 LEU A CD2 1 
ATOM   1972 N N   . GLY A 1 185 ? 28.23421  -4.28490  -25.20184 1.000 10.62779 ? 266 GLY A N   1 
ATOM   1973 C CA  . GLY A 1 185 ? 28.63076  -4.89372  -26.45826 1.000 10.80821 ? 266 GLY A CA  1 
ATOM   1974 C C   . GLY A 1 185 ? 29.46159  -4.01181  -27.36940 1.000 10.47332 ? 266 GLY A C   1 
ATOM   1975 O O   . GLY A 1 185 ? 30.05030  -4.52515  -28.32209 1.000 11.17037 ? 266 GLY A O   1 
ATOM   1976 N N   . TRP A 1 186 ? 29.49379  -2.70340  -27.13516 1.000 10.48352 ? 267 TRP A N   1 
ATOM   1977 C CA  . TRP A 1 186 ? 30.46902  -1.86423  -27.81597 1.000 11.11974 ? 267 TRP A CA  1 
ATOM   1978 C C   . TRP A 1 186 ? 31.83295  -2.53000  -27.72853 1.000 10.68378 ? 267 TRP A C   1 
ATOM   1979 O O   . TRP A 1 186 ? 32.24761  -2.91733  -26.62960 1.000 10.85276 ? 267 TRP A O   1 
ATOM   1980 C CB  . TRP A 1 186 ? 30.54036  -0.50158  -27.12486 1.000 10.74241 ? 267 TRP A CB  1 
ATOM   1981 C CG  . TRP A 1 186 ? 29.32075  0.30635   -27.39436 1.000 10.54270 ? 267 TRP A CG  1 
ATOM   1982 C CD1 . TRP A 1 186 ? 28.17339  0.34013   -26.65467 1.000 10.91162 ? 267 TRP A CD1 1 
ATOM   1983 C CD2 . TRP A 1 186 ? 29.09607  1.16252   -28.51594 1.000 10.67987 ? 267 TRP A CD2 1 
ATOM   1984 N NE1 . TRP A 1 186 ? 27.25301  1.16447   -27.25077 1.000 10.67202 ? 267 TRP A NE1 1 
ATOM   1985 C CE2 . TRP A 1 186 ? 27.78950  1.67556   -28.40247 1.000 10.75740 ? 267 TRP A CE2 1 
ATOM   1986 C CE3 . TRP A 1 186 ? 29.88449  1.54636   -29.60711 1.000 10.76495 ? 267 TRP A CE3 1 
ATOM   1987 C CZ2 . TRP A 1 186 ? 27.25321  2.57375   -29.33288 1.000 11.81912 ? 267 TRP A CZ2 1 
ATOM   1988 C CZ3 . TRP A 1 186 ? 29.34923  2.43906   -30.53192 1.000 13.15454 ? 267 TRP A CZ3 1 
ATOM   1989 C CH2 . TRP A 1 186 ? 28.05431  2.94636   -30.38567 1.000 12.17552 ? 267 TRP A CH2 1 
ATOM   1990 N N   . PRO A 1 187 ? 32.54835  -2.69127  -28.84901 1.000 10.73072 ? 268 PRO A N   1 
ATOM   1991 C CA  . PRO A 1 187 ? 33.84613  -3.38685  -28.79160 1.000 11.74267 ? 268 PRO A CA  1 
ATOM   1992 C C   . PRO A 1 187 ? 34.76085  -2.90240  -27.68969 1.000 10.73251 ? 268 PRO A C   1 
ATOM   1993 O O   . PRO A 1 187 ? 35.39913  -3.72022  -27.02250 1.000 12.07596 ? 268 PRO A O   1 
ATOM   1994 C CB  . PRO A 1 187 ? 34.42485  -3.15458  -30.19448 1.000 13.21986 ? 268 PRO A CB  1 
ATOM   1995 C CG  . PRO A 1 187 ? 33.20302  -3.14970  -31.06071 1.000 13.61461 ? 268 PRO A CG  1 
ATOM   1996 C CD  . PRO A 1 187 ? 32.12661  -2.46199  -30.24233 1.000 12.03435 ? 268 PRO A CD  1 
ATOM   1997 N N   . ALA A 1 188 ? 34.82051  -1.59050  -27.45826 1.000 11.41329 ? 269 ALA A N   1 
ATOM   1998 C CA  . ALA A 1 188 ? 35.70096  -1.06010  -26.43453 1.000 11.39632 ? 269 ALA A CA  1 
ATOM   1999 C C   . ALA A 1 188 ? 35.25574  -1.41086  -25.01681 1.000 10.73977 ? 269 ALA A C   1 
ATOM   2000 O O   . ALA A 1 188 ? 36.06824  -1.31312  -24.09204 1.000 12.04337 ? 269 ALA A O   1 
ATOM   2001 C CB  . ALA A 1 188 ? 35.80320  0.45499   -26.58655 1.000 12.81329 ? 269 ALA A CB  1 
ATOM   2002 N N   . ASN A 1 189 ? 33.98914  -1.79883  -24.81232 1.000 10.37216 ? 270 ASN A N   1 
ATOM   2003 C CA  . ASN A 1 189 ? 33.55211  -2.17389  -23.47245 1.000 10.51609 ? 270 ASN A CA  1 
ATOM   2004 C C   . ASN A 1 189 ? 33.72240  -3.66025  -23.18554 1.000 10.88859 ? 270 ASN A C   1 
ATOM   2005 O O   . ASN A 1 189 ? 33.57274  -4.07743  -22.02933 1.000 11.41416 ? 270 ASN A O   1 
ATOM   2006 C CB  . ASN A 1 189 ? 32.09222  -1.77103  -23.24657 1.000 10.97543 ? 270 ASN A CB  1 
ATOM   2007 C CG  . ASN A 1 189 ? 31.90851  -0.27314  -23.18051 1.000 10.79377 ? 270 ASN A CG  1 
ATOM   2008 O OD1 . ASN A 1 189 ? 32.86722  0.46804   -22.90908 1.000 11.62546 ? 270 ASN A OD1 1 
ATOM   2009 N ND2 . ASN A 1 189 ? 30.68635  0.18674   -23.43939 1.000 10.39464 ? 270 ASN A ND2 1 
ATOM   2010 N N   . LEU A 1 190 ? 34.05487  -4.46126  -24.19877 1.000 11.49926 ? 271 LEU A N   1 
ATOM   2011 C CA  . LEU A 1 190 ? 34.04381  -5.91442  -24.03619 1.000 11.59077 ? 271 LEU A CA  1 
ATOM   2012 C C   . LEU A 1 190 ? 35.11732  -6.38814  -23.06918 1.000 10.82006 ? 271 LEU A C   1 
ATOM   2013 O O   . LEU A 1 190 ? 34.84579  -7.20616  -22.17819 1.000 12.04792 ? 271 LEU A O   1 
ATOM   2014 C CB  . LEU A 1 190 ? 34.24407  -6.59761  -25.38081 1.000 12.86434 ? 271 LEU A CB  1 
ATOM   2015 C CG  . LEU A 1 190 ? 33.14343  -6.48251  -26.41996 1.000 12.67113 ? 271 LEU A CG  1 
ATOM   2016 C CD1 . LEU A 1 190 ? 33.69758  -6.98817  -27.73852 1.000 13.99087 ? 271 LEU A CD1 1 
ATOM   2017 C CD2 . LEU A 1 190 ? 31.90981  -7.26774  -25.98864 1.000 12.31387 ? 271 LEU A CD2 1 
ATOM   2018 N N   A SER A 1 191 ? 36.35783  -5.96666  -23.28054 0.576 12.69300 ? 272 SER A N   1 
ATOM   2019 N N   B SER A 1 191 ? 36.33955  -5.86123  -23.20118 0.424 12.54722 ? 272 SER A N   1 
ATOM   2020 C CA  A SER A 1 191 ? 37.41922  -6.39339  -22.37349 0.576 13.16015 ? 272 SER A CA  1 
ATOM   2021 C CA  B SER A 1 191 ? 37.41583  -6.30303  -22.31478 0.424 13.19762 ? 272 SER A CA  1 
ATOM   2022 C C   A SER A 1 191 ? 37.20910  -5.86680  -20.96180 0.576 11.65406 ? 272 SER A C   1 
ATOM   2023 C C   B SER A 1 191 ? 37.22317  -5.88263  -20.86145 0.424 11.71575 ? 272 SER A C   1 
ATOM   2024 O O   A SER A 1 191 ? 37.36767  -6.64474  -20.00362 0.576 12.52649 ? 272 SER A O   1 
ATOM   2025 O O   B SER A 1 191 ? 37.35362  -6.74457  -19.97427 0.424 12.49039 ? 272 SER A O   1 
ATOM   2026 C CB  A SER A 1 191 ? 38.78798  -6.04243  -22.96329 0.576 15.88776 ? 272 SER A CB  1 
ATOM   2027 C CB  B SER A 1 191 ? 38.78440  -5.94072  -22.90010 0.424 15.88402 ? 272 SER A CB  1 
ATOM   2028 O OG  A SER A 1 191 ? 39.81634  -6.26966  -22.01740 0.576 14.53860 ? 272 SER A OG  1 
ATOM   2029 O OG  B SER A 1 191 ? 39.03422  -6.67448  -24.09036 0.424 20.41629 ? 272 SER A OG  1 
ATOM   2030 N N   A PRO A 1 192 ? 36.85914  -4.59550  -20.74961 0.576 11.28130 ? 273 PRO A N   1 
ATOM   2031 N N   B PRO A 1 192 ? 36.92791  -4.61906  -20.53180 0.424 11.45130 ? 273 PRO A N   1 
ATOM   2032 C CA  A PRO A 1 192 ? 36.49067  -4.17693  -19.39025 0.576 13.04448 ? 273 PRO A CA  1 
ATOM   2033 C CA  B PRO A 1 192 ? 36.68264  -4.30738  -19.11535 0.424 12.35522 ? 273 PRO A CA  1 
ATOM   2034 C C   A PRO A 1 192 ? 35.37819  -5.01701  -18.78352 0.576 11.31575 ? 273 PRO A C   1 
ATOM   2035 C C   B PRO A 1 192 ? 35.50096  -5.07001  -18.54662 0.424 11.23700 ? 273 PRO A C   1 
ATOM   2036 O O   A PRO A 1 192 ? 35.45454  -5.37079  -17.60100 0.576 11.70804 ? 273 PRO A O   1 
ATOM   2037 O O   B PRO A 1 192 ? 35.50072  -5.40588  -17.35570 0.424 12.24132 ? 273 PRO A O   1 
ATOM   2038 C CB  A PRO A 1 192 ? 36.08880  -2.70669  -19.56734 0.576 14.80857 ? 273 PRO A CB  1 
ATOM   2039 C CB  B PRO A 1 192 ? 36.43646  -2.79077  -19.11168 0.424 13.27091 ? 273 PRO A CB  1 
ATOM   2040 C CG  A PRO A 1 192 ? 36.80203  -2.25762  -20.78899 0.576 16.50703 ? 273 PRO A CG  1 
ATOM   2041 C CG  B PRO A 1 192 ? 36.05321  -2.45756  -20.51053 0.424 12.43925 ? 273 PRO A CG  1 
ATOM   2042 C CD  A PRO A 1 192 ? 36.95805  -3.44865  -21.67566 0.576 11.44665 ? 273 PRO A CD  1 
ATOM   2043 C CD  B PRO A 1 192 ? 36.82611  -3.41315  -21.37522 0.424 12.57340 ? 273 PRO A CD  1 
ATOM   2044 N N   A ALA A 1 193 ? 34.34803  -5.34996  -19.56372 0.576 10.41124 ? 274 ALA A N   1 
ATOM   2045 N N   B ALA A 1 193 ? 34.49209  -5.35558  -19.37089 0.424 10.44578 ? 274 ALA A N   1 
ATOM   2046 C CA  A ALA A 1 193 ? 33.27244  -6.19068  -19.04584 0.576 10.76513 ? 274 ALA A CA  1 
ATOM   2047 C CA  B ALA A 1 193 ? 33.36758  -6.16296  -18.91172 0.424 10.72398 ? 274 ALA A CA  1 
ATOM   2048 C C   A ALA A 1 193 ? 33.79616  -7.56657  -18.65181 0.576 11.02176 ? 274 ALA A C   1 
ATOM   2049 C C   B ALA A 1 193 ? 33.80483  -7.59344  -18.62538 0.424 11.01602 ? 274 ALA A C   1 
ATOM   2050 O O   A ALA A 1 193 ? 33.53391  -8.05148  -17.54298 0.576 11.18871 ? 274 ALA A O   1 
ATOM   2051 O O   B ALA A 1 193 ? 33.46910  -8.15661  -17.57584 0.424 11.19207 ? 274 ALA A O   1 
ATOM   2052 C CB  A ALA A 1 193 ? 32.16101  -6.31499  -20.08670 0.576 12.60570 ? 274 ALA A CB  1 
ATOM   2053 C CB  B ALA A 1 193 ? 32.24451  -6.13892  -19.94672 0.424 12.49882 ? 274 ALA A CB  1 
ATOM   2054 N N   . ALA A 1 194 ? 34.55331  -8.20189  -19.55068 1.000 10.96199 ? 275 ALA A N   1 
ATOM   2055 C CA  . ALA A 1 194 ? 35.07391  -9.53585  -19.29076 1.000 11.94245 ? 275 ALA A CA  1 
ATOM   2056 C C   . ALA A 1 194 ? 35.93408  -9.54234  -18.04072 1.000 11.94730 ? 275 ALA A C   1 
ATOM   2057 O O   . ALA A 1 194 ? 35.84078  -10.46190 -17.22470 1.000 12.40201 ? 275 ALA A O   1 
ATOM   2058 C CB  . ALA A 1 194 ? 35.87532  -10.01731 -20.49798 1.000 12.63488 ? 275 ALA A CB  1 
ATOM   2059 N N   . GLN A 1 195 ? 36.77392  -8.52199  -17.86877 1.000 11.69915 ? 276 GLN A N   1 
ATOM   2060 C CA  A GLN A 1 195 ? 37.61968  -8.49081  -16.68584 0.772 13.17793 ? 276 GLN A CA  1 
ATOM   2061 C CA  B GLN A 1 195 ? 37.62075  -8.43126  -16.67909 0.228 13.21223 ? 276 GLN A CA  1 
ATOM   2062 C C   . GLN A 1 195 ? 36.78308  -8.42526  -15.41132 1.000 11.49894 ? 276 GLN A C   1 
ATOM   2063 O O   . GLN A 1 195 ? 37.10772  -9.09649  -14.42397 1.000 12.19009 ? 276 GLN A O   1 
ATOM   2064 C CB  A GLN A 1 195 ? 38.59328  -7.31907  -16.77826 0.772 13.74025 ? 276 GLN A CB  1 
ATOM   2065 C CB  B GLN A 1 195 ? 38.45632  -7.15099  -16.72676 0.228 13.43411 ? 276 GLN A CB  1 
ATOM   2066 C CG  A GLN A 1 195 ? 39.60418  -7.47766  -17.90699 0.772 18.73295 ? 276 GLN A CG  1 
ATOM   2067 C CG  B GLN A 1 195 ? 39.57063  -7.14147  -17.74622 0.228 17.33624 ? 276 GLN A CG  1 
ATOM   2068 C CD  A GLN A 1 195 ? 40.36148  -6.19868  -18.19554 0.772 18.99553 ? 276 GLN A CD  1 
ATOM   2069 C CD  B GLN A 1 195 ? 40.33342  -5.83214  -17.74013 0.228 19.72724 ? 276 GLN A CD  1 
ATOM   2070 O OE1 A GLN A 1 195 ? 40.27741  -5.64149  -19.29472 0.772 21.07053 ? 276 GLN A OE1 1 
ATOM   2071 O OE1 B GLN A 1 195 ? 39.78169  -4.77631  -17.42883 0.228 20.27096 ? 276 GLN A OE1 1 
ATOM   2072 N NE2 A GLN A 1 195 ? 41.10764  -5.72384  -17.20522 0.772 23.82814 ? 276 GLN A NE2 1 
ATOM   2073 N NE2 B GLN A 1 195 ? 41.61511  -5.89837  -18.06103 0.228 22.35677 ? 276 GLN A NE2 1 
ATOM   2074 N N   A LEU A 1 196 ? 35.73085  -7.60443  -15.41207 0.803 10.51506 ? 277 LEU A N   1 
ATOM   2075 N N   B LEU A 1 196 ? 35.68145  -7.67483  -15.41744 0.197 10.67342 ? 277 LEU A N   1 
ATOM   2076 C CA  A LEU A 1 196 ? 34.88993  -7.47511  -14.23468 0.803 10.75764 ? 277 LEU A CA  1 
ATOM   2077 C CA  B LEU A 1 196 ? 34.83848  -7.61796  -14.23073 0.197 10.98906 ? 277 LEU A CA  1 
ATOM   2078 C C   A LEU A 1 196 ? 34.15571  -8.77684  -13.94908 0.803 10.51914 ? 277 LEU A C   1 
ATOM   2079 C C   B LEU A 1 196 ? 34.15055  -8.95442  -13.97580 0.197 10.59088 ? 277 LEU A C   1 
ATOM   2080 O O   A LEU A 1 196 ? 34.19124  -9.27560  -12.81895 0.803 11.36116 ? 277 LEU A O   1 
ATOM   2081 O O   B LEU A 1 196 ? 34.08497  -9.41317  -12.82960 0.197 11.71768 ? 277 LEU A O   1 
ATOM   2082 C CB  A LEU A 1 196 ? 33.89447  -6.33837  -14.43112 0.803 11.88329 ? 277 LEU A CB  1 
ATOM   2083 C CB  B LEU A 1 196 ? 33.81257  -6.49382  -14.36750 0.197 11.52058 ? 277 LEU A CB  1 
ATOM   2084 C CG  A LEU A 1 196 ? 32.94028  -6.22417  -13.25538 0.803 10.80557 ? 277 LEU A CG  1 
ATOM   2085 C CG  B LEU A 1 196 ? 32.54762  -6.64624  -13.52578 0.197 11.41724 ? 277 LEU A CG  1 
ATOM   2086 C CD1 A LEU A 1 196 ? 33.68403  -5.94661  -11.96550 0.803 18.33159 ? 277 LEU A CD1 1 
ATOM   2087 C CD1 B LEU A 1 196 ? 32.83336  -6.18880  -12.10327 0.197 17.18277 ? 277 LEU A CD1 1 
ATOM   2088 C CD2 A LEU A 1 196 ? 31.89346  -5.16556  -13.52824 0.803 14.82632 ? 277 LEU A CD2 1 
ATOM   2089 C CD2 B LEU A 1 196 ? 31.40195  -5.85553  -14.12447 0.197 15.29425 ? 277 LEU A CD2 1 
ATOM   2090 N N   A PHE A 1 197 ? 33.48546  -9.34516  -14.95987 0.803 9.81476  ? 278 PHE A N   1 
ATOM   2091 N N   B PHE A 1 197 ? 33.66026  -9.61013  -15.03084 0.197 10.86008 ? 278 PHE A N   1 
ATOM   2092 C CA  A PHE A 1 197 ? 32.72233  -10.56993 -14.72222 0.803 9.92074  ? 278 PHE A CA  1 
ATOM   2093 C CA  B PHE A 1 197 ? 32.79266  -10.76650 -14.82552 0.197 10.53139 ? 278 PHE A CA  1 
ATOM   2094 C C   A PHE A 1 197 ? 33.63040  -11.70525 -14.26937 0.803 10.03309 ? 278 PHE A C   1 
ATOM   2095 C C   B PHE A 1 197 ? 33.56134  -12.04026 -14.46433 0.197 10.49767 ? 278 PHE A C   1 
ATOM   2096 O O   A PHE A 1 197 ? 33.24449  -12.50839 -13.41148 0.803 9.51266  ? 278 PHE A O   1 
ATOM   2097 O O   B PHE A 1 197 ? 33.08314  -12.82696 -13.63982 0.197 9.94531  ? 278 PHE A O   1 
ATOM   2098 C CB  A PHE A 1 197 ? 31.93922  -10.99387 -15.96782 0.803 11.68860 ? 278 PHE A CB  1 
ATOM   2099 C CB  B PHE A 1 197 ? 31.83834  -10.95899 -16.00929 0.197 11.59626 ? 278 PHE A CB  1 
ATOM   2100 C CG  A PHE A 1 197 ? 30.86415  -10.02844 -16.37256 0.803 11.10274 ? 278 PHE A CG  1 
ATOM   2101 C CG  B PHE A 1 197 ? 30.70072  -9.95878  -16.04697 0.197 9.92264  ? 278 PHE A CG  1 
ATOM   2102 C CD1 A PHE A 1 197 ? 29.91899  -9.61326  -15.46260 0.803 11.95500 ? 278 PHE A CD1 1 
ATOM   2103 C CD1 B PHE A 1 197 ? 29.76710  -9.90524  -15.02435 0.197 10.11235 ? 278 PHE A CD1 1 
ATOM   2104 C CD2 A PHE A 1 197 ? 30.80034  -9.54479  -17.66783 0.803 11.51293 ? 278 PHE A CD2 1 
ATOM   2105 C CD2 B PHE A 1 197 ? 30.56622  -9.07990  -17.11124 0.197 10.00260 ? 278 PHE A CD2 1 
ATOM   2106 C CE1 A PHE A 1 197 ? 28.92670  -8.71326  -15.83018 0.803 12.23129 ? 278 PHE A CE1 1 
ATOM   2107 C CE1 B PHE A 1 197 ? 28.72296  -8.99402  -15.06018 0.197 10.27757 ? 278 PHE A CE1 1 
ATOM   2108 C CE2 A PHE A 1 197 ? 29.81052  -8.64854  -18.04297 0.803 12.22092 ? 278 PHE A CE2 1 
ATOM   2109 C CE2 B PHE A 1 197 ? 29.52825  -8.16361  -17.15252 0.197 10.50837 ? 278 PHE A CE2 1 
ATOM   2110 C CZ  A PHE A 1 197 ? 28.88654  -8.22130  -17.11910 0.803 13.06570 ? 278 PHE A CZ  1 
ATOM   2111 C CZ  B PHE A 1 197 ? 28.60724  -8.11920  -16.12516 0.197 12.35140 ? 278 PHE A CZ  1 
ATOM   2112 N N   A THR A 1 198 ? 34.83626  -11.80098 -14.83733 0.803 9.68967  ? 279 THR A N   1 
ATOM   2113 N N   B THR A 1 198 ? 34.74253  -12.28536 -15.04795 0.197 11.28508 ? 279 THR A N   1 
ATOM   2114 C CA  A THR A 1 198 ? 35.73033  -12.87333 -14.41750 0.803 9.83656  ? 279 THR A CA  1 
ATOM   2115 C CA  B THR A 1 198 ? 35.50521  -13.43661 -14.55657 0.197 11.37782 ? 279 THR A CA  1 
ATOM   2116 C C   A THR A 1 198 ? 36.21879  -12.67277 -12.98818 0.803 10.35474 ? 279 THR A C   1 
ATOM   2117 C C   B THR A 1 198 ? 36.13879  -13.15453 -13.20068 0.197 12.03225 ? 279 THR A C   1 
ATOM   2118 O O   A THR A 1 198 ? 36.33898  -13.64532 -12.23743 0.803 11.03830 ? 279 THR A O   1 
ATOM   2119 O O   B THR A 1 198 ? 36.37722  -14.08869 -12.42960 0.197 12.17100 ? 279 THR A O   1 
ATOM   2120 C CB  A THR A 1 198 ? 36.87359  -13.07770 -15.41438 0.803 11.01089 ? 279 THR A CB  1 
ATOM   2121 C CB  B THR A 1 198 ? 36.54408  -13.97235 -15.55570 0.197 15.38184 ? 279 THR A CB  1 
ATOM   2122 O OG1 A THR A 1 198 ? 37.67135  -11.90077 -15.51976 0.803 18.50112 ? 279 THR A OG1 1 
ATOM   2123 O OG1 B THR A 1 198 ? 37.87320  -13.80082 -15.03444 0.197 10.40641 ? 279 THR A OG1 1 
ATOM   2124 C CG2 A THR A 1 198 ? 36.31913  -13.43788 -16.76720 0.803 14.19916 ? 279 THR A CG2 1 
ATOM   2125 C CG2 B THR A 1 198 ? 36.42713  -13.30665 -16.89864 0.197 14.10897 ? 279 THR A CG2 1 
ATOM   2126 N N   A GLN A 1 199 ? 36.48450  -11.42919 -12.57589 0.803 9.91771  ? 280 GLN A N   1 
ATOM   2127 N N   B GLN A 1 199 ? 36.42303  -11.88614 -12.89315 0.197 11.41264 ? 280 GLN A N   1 
ATOM   2128 C CA  A GLN A 1 199 ? 36.84969  -11.20021 -11.17911 0.803 11.21786 ? 280 GLN A CA  1 
ATOM   2129 C CA  B GLN A 1 199 ? 36.85124  -11.53615 -11.54133 0.197 12.46323 ? 280 GLN A CA  1 
ATOM   2130 C C   A GLN A 1 199 ? 35.72206  -11.61606 -10.23870 0.803 9.70770  ? 280 GLN A C   1 
ATOM   2131 C C   B GLN A 1 199 ? 35.76974  -11.87426 -10.52347 0.197 9.57618  ? 280 GLN A C   1 
ATOM   2132 O O   A GLN A 1 199 ? 35.96621  -12.19529 -9.17023  0.803 9.91370  ? 280 GLN A O   1 
ATOM   2133 O O   B GLN A 1 199 ? 36.01777  -12.60759 -9.55928  0.197 10.62314 ? 280 GLN A O   1 
ATOM   2134 C CB  A GLN A 1 199 ? 37.21795  -9.73489  -10.97010 0.803 12.52588 ? 280 GLN A CB  1 
ATOM   2135 C CB  B GLN A 1 199 ? 37.22104  -10.05556 -11.46172 0.197 12.32692 ? 280 GLN A CB  1 
ATOM   2136 C CG  A GLN A 1 199 ? 37.68131  -9.44217  -9.56340  0.803 15.60057 ? 280 GLN A CG  1 
ATOM   2137 C CG  B GLN A 1 199 ? 38.36123  -9.75291  -10.50329 0.197 19.70672 ? 280 GLN A CG  1 
ATOM   2138 C CD  A GLN A 1 199 ? 38.98477  -10.15616 -9.23385  0.803 20.20254 ? 280 GLN A CD  1 
ATOM   2139 C CD  B GLN A 1 199 ? 37.87399  -9.41655  -9.10655  0.197 18.53949 ? 280 GLN A CD  1 
ATOM   2140 O OE1 A GLN A 1 199 ? 40.03810  -9.81825  -9.77458  0.803 23.61539 ? 280 GLN A OE1 1 
ATOM   2141 O OE1 B GLN A 1 199 ? 36.67163  -9.37860  -8.85039  0.197 19.50902 ? 280 GLN A OE1 1 
ATOM   2142 N NE2 A GLN A 1 199 ? 38.92015  -11.14470 -8.34810  0.803 17.60019 ? 280 GLN A NE2 1 
ATOM   2143 N NE2 B GLN A 1 199 ? 38.80970  -9.16767  -8.19415  0.197 18.85532 ? 280 GLN A NE2 1 
ATOM   2144 N N   A VAL A 1 200 ? 34.47982  -11.32300 -10.62402 0.803 10.74199 ? 281 VAL A N   1 
ATOM   2145 N N   B VAL A 1 200 ? 34.55937  -11.34214 -10.72426 0.197 10.84507 ? 281 VAL A N   1 
ATOM   2146 C CA  A VAL A 1 200 ? 33.31929  -11.71726 -9.83029  0.803 10.37632 ? 281 VAL A CA  1 
ATOM   2147 C CA  B VAL A 1 200 ? 33.44368  -11.62933 -9.82339  0.197 10.48702 ? 281 VAL A CA  1 
ATOM   2148 C C   A VAL A 1 200 ? 33.21970  -13.23873 -9.75568  0.803 10.63098 ? 281 VAL A C   1 
ATOM   2149 C C   B VAL A 1 200 ? 33.21274  -13.13277 -9.71817  0.197 10.69724 ? 281 VAL A C   1 
ATOM   2150 O O   A VAL A 1 200 ? 33.02271  -13.81956 -8.67977  0.803 10.70630 ? 281 VAL A O   1 
ATOM   2151 O O   B VAL A 1 200 ? 32.97396  -13.66697 -8.62773  0.197 10.81536 ? 281 VAL A O   1 
ATOM   2152 C CB  A VAL A 1 200 ? 32.05100  -11.07398 -10.42258 0.803 9.77020  ? 281 VAL A CB  1 
ATOM   2153 C CB  B VAL A 1 200 ? 32.18015  -10.87700 -10.28801 0.197 10.58389 ? 281 VAL A CB  1 
ATOM   2154 C CG1 A VAL A 1 200 ? 30.79659  -11.63293 -9.77534  0.803 11.57329 ? 281 VAL A CG1 1 
ATOM   2155 C CG1 B VAL A 1 200 ? 30.93582  -11.42414 -9.60347  0.197 11.96084 ? 281 VAL A CG1 1 
ATOM   2156 C CG2 A VAL A 1 200 ? 32.11998  -9.55520  -10.26407 0.803 12.18362 ? 281 VAL A CG2 1 
ATOM   2157 C CG2 B VAL A 1 200 ? 32.32440  -9.38443  -10.03234 0.197 11.28759 ? 281 VAL A CG2 1 
ATOM   2158 N N   A TRP A 1 201 ? 33.37778  -13.90443 -10.90094 0.803 10.16985 ? 282 TRP A N   1 
ATOM   2159 N N   B TRP A 1 201 ? 33.30064  -13.83885 -10.84828 0.197 10.35432 ? 282 TRP A N   1 
ATOM   2160 C CA  A TRP A 1 201 ? 33.37061  -15.35997 -10.93141 0.803 10.32159 ? 282 TRP A CA  1 
ATOM   2161 C CA  B TRP A 1 201 ? 33.11796  -15.28623 -10.85495 0.197 10.94742 ? 282 TRP A CA  1 
ATOM   2162 C C   A TRP A 1 201 ? 34.46581  -15.93151 -10.02384 0.803 9.72970  ? 282 TRP A C   1 
ATOM   2163 C C   B TRP A 1 201 ? 34.24355  -15.99577 -10.11063 0.197 10.93753 ? 282 TRP A C   1 
ATOM   2164 O O   A TRP A 1 201 ? 34.21427  -16.85623 -9.23345  0.803 10.01486 ? 282 TRP A O   1 
ATOM   2165 O O   B TRP A 1 201 ? 34.00895  -17.02539 -9.46616  0.197 12.83572 ? 282 TRP A O   1 
ATOM   2166 C CB  A TRP A 1 201 ? 33.50929  -15.76563 -12.39818 0.803 10.17772 ? 282 TRP A CB  1 
ATOM   2167 C CB  B TRP A 1 201 ? 33.00164  -15.75727 -12.30626 0.197 9.98078  ? 282 TRP A CB  1 
ATOM   2168 C CG  A TRP A 1 201 ? 33.70234  -17.20449 -12.73034 0.803 9.90200  ? 282 TRP A CG  1 
ATOM   2169 C CG  B TRP A 1 201 ? 33.34161  -17.19242 -12.57974 0.197 11.01698 ? 282 TRP A CG  1 
ATOM   2170 C CD1 A TRP A 1 201 ? 32.76017  -18.18460 -12.70611 0.803 10.44945 ? 282 TRP A CD1 1 
ATOM   2171 C CD1 B TRP A 1 201 ? 32.50746  -18.26926 -12.47300 0.197 11.35159 ? 282 TRP A CD1 1 
ATOM   2172 C CD2 A TRP A 1 201 ? 34.89695  -17.81055 -13.23435 0.803 11.33837 ? 282 TRP A CD2 1 
ATOM   2173 C CD2 B TRP A 1 201 ? 34.59390  -17.69989 -13.05297 0.197 11.27212 ? 282 TRP A CD2 1 
ATOM   2174 N NE1 A TRP A 1 201 ? 33.30252  -19.37855 -13.13783 0.803 10.63005 ? 282 TRP A NE1 1 
ATOM   2175 N NE1 B TRP A 1 201 ? 33.17179  -19.41849 -12.83502 0.197 11.40504 ? 282 TRP A NE1 1 
ATOM   2176 C CE2 A TRP A 1 201 ? 34.61649  -19.16580 -13.46879 0.803 10.17484 ? 282 TRP A CE2 1 
ATOM   2177 C CE2 B TRP A 1 201 ? 34.45432  -19.09372 -13.19472 0.197 11.18868 ? 282 TRP A CE2 1 
ATOM   2178 C CE3 A TRP A 1 201 ? 36.18019  -17.33226 -13.50072 0.803 11.40232 ? 282 TRP A CE3 1 
ATOM   2179 C CE3 B TRP A 1 201 ? 35.82273  -17.11036 -13.36183 0.197 12.54763 ? 282 TRP A CE3 1 
ATOM   2180 C CZ2 A TRP A 1 201 ? 35.58124  -20.05450 -13.95039 0.803 12.19742 ? 282 TRP A CZ2 1 
ATOM   2181 C CZ2 B TRP A 1 201 ? 35.49675  -19.90564 -13.63388 0.197 12.91571 ? 282 TRP A CZ2 1 
ATOM   2182 C CZ3 A TRP A 1 201 ? 37.12912  -18.20341 -13.99109 0.803 12.65093 ? 282 TRP A CZ3 1 
ATOM   2183 C CZ3 B TRP A 1 201 ? 36.85599  -17.91708 -13.79176 0.197 12.46642 ? 282 TRP A CZ3 1 
ATOM   2184 C CH2 A TRP A 1 201 ? 36.82952  -19.55282 -14.20593 0.803 12.61662 ? 282 TRP A CH2 1 
ATOM   2185 C CH2 B TRP A 1 201 ? 36.68686  -19.29912 -13.92506 0.197 13.89084 ? 282 TRP A CH2 1 
ATOM   2186 N N   A GLN A 1 202 ? 35.67255  -15.35918 -10.08659 0.803 10.23332 ? 283 GLN A N   1 
ATOM   2187 N N   B GLN A 1 202 ? 35.46166  -15.45233 -10.16928 0.197 10.76209 ? 283 GLN A N   1 
ATOM   2188 C CA  A GLN A 1 202 ? 36.76250  -15.82576 -9.23079  0.803 10.92925 ? 283 GLN A CA  1 
ATOM   2189 C CA  B GLN A 1 202 ? 36.58005  -16.05418 -9.44996  0.197 11.11320 ? 283 GLN A CA  1 
ATOM   2190 C C   A GLN A 1 202 ? 36.44613  -15.62160 -7.75320  0.803 9.92489  ? 283 GLN A C   1 
ATOM   2191 C C   B GLN A 1 202 ? 36.47858  -15.79987 -7.94841  0.197 10.75801 ? 283 GLN A C   1 
ATOM   2192 O O   A GLN A 1 202 ? 36.69669  -16.51358 -6.92724  0.803 10.83401 ? 283 GLN A O   1 
ATOM   2193 O O   B GLN A 1 202 ? 36.83098  -16.67157 -7.14326  0.197 10.92459 ? 283 GLN A O   1 
ATOM   2194 C CB  A GLN A 1 202 ? 38.05888  -15.10736 -9.59457  0.803 12.06644 ? 283 GLN A CB  1 
ATOM   2195 C CB  B GLN A 1 202 ? 37.90174  -15.53490 -10.01850 0.197 13.12428 ? 283 GLN A CB  1 
ATOM   2196 C CG  A GLN A 1 202 ? 38.64504  -15.53490 -10.91719 0.803 15.48314 ? 283 GLN A CG  1 
ATOM   2197 C CG  B GLN A 1 202 ? 39.11117  -15.76286 -9.13461  0.197 15.95621 ? 283 GLN A CG  1 
ATOM   2198 C CD  A GLN A 1 202 ? 39.65818  -14.54395 -11.45558 0.803 19.19658 ? 283 GLN A CD  1 
ATOM   2199 C CD  B GLN A 1 202 ? 39.48791  -14.54002 -8.33487  0.197 19.42597 ? 283 GLN A CD  1 
ATOM   2200 O OE1 A GLN A 1 202 ? 39.90891  -13.50026 -10.85130 0.803 25.15592 ? 283 GLN A OE1 1 
ATOM   2201 O OE1 B GLN A 1 202 ? 39.42249  -14.54240 -7.10595  0.197 19.74667 ? 283 GLN A OE1 1 
ATOM   2202 N NE2 A GLN A 1 202 ? 40.25467  -14.87324 -12.59830 0.803 29.23617 ? 283 GLN A NE2 1 
ATOM   2203 N NE2 B GLN A 1 202 ? 39.89574  -13.48368 -9.02961  0.197 19.85931 ? 283 GLN A NE2 1 
ATOM   2204 N N   A ASN A 1 203 ? 35.93204  -14.43971 -7.38814  0.803 10.12172 ? 284 ASN A N   1 
ATOM   2205 N N   B ASN A 1 203 ? 35.99803  -14.61497 -7.54964  0.197 11.02875 ? 284 ASN A N   1 
ATOM   2206 C CA  A ASN A 1 203 ? 35.68123  -14.17713 -5.97489  0.803 9.94714  ? 284 ASN A CA  1 
ATOM   2207 C CA  B ASN A 1 203 ? 35.81718  -14.33185 -6.12692  0.197 10.23432 ? 284 ASN A CA  1 
ATOM   2208 C C   A ASN A 1 203 ? 34.64567  -15.12805 -5.40926  0.803 10.80070 ? 284 ASN A C   1 
ATOM   2209 C C   B ASN A 1 203 ? 34.76047  -15.23040 -5.49323  0.197 11.29606 ? 284 ASN A C   1 
ATOM   2210 O O   A ASN A 1 203 ? 34.69180  -15.46167 -4.21940  0.803 11.51174 ? 284 ASN A O   1 
ATOM   2211 O O   B ASN A 1 203 ? 34.88341  -15.59696 -4.31862  0.197 11.46179 ? 284 ASN A O   1 
ATOM   2212 C CB  A ASN A 1 203 ? 35.24013  -12.73362 -5.75058  0.803 12.05570 ? 284 ASN A CB  1 
ATOM   2213 C CB  B ASN A 1 203 ? 35.48754  -12.85432 -5.90036  0.197 12.18115 ? 284 ASN A CB  1 
ATOM   2214 C CG  A ASN A 1 203 ? 36.39554  -11.78034 -5.75730  0.803 10.91042 ? 284 ASN A CG  1 
ATOM   2215 C CG  B ASN A 1 203 ? 36.34919  -11.92887 -6.73088  0.197 14.39270 ? 284 ASN A CG  1 
ATOM   2216 O OD1 A ASN A 1 203 ? 37.55256  -12.19272 -5.67400  0.803 13.16172 ? 284 ASN A OD1 1 
ATOM   2217 O OD1 B ASN A 1 203 ? 37.53669  -12.18470 -6.93546  0.197 18.18818 ? 284 ASN A OD1 1 
ATOM   2218 N ND2 A ASN A 1 203 ? 36.09682  -10.49744 -5.87847  0.803 13.57515 ? 284 ASN A ND2 1 
ATOM   2219 N ND2 B ASN A 1 203 ? 35.75404  -10.84888 -7.22200  0.197 16.93871 ? 284 ASN A ND2 1 
ATOM   2220 N N   . ALA A 1 204 ? 33.72527  -15.59927 -6.24816  1.000 10.46451 ? 285 ALA A N   1 
ATOM   2221 C CA  . ALA A 1 204 ? 32.71127  -16.53461 -5.80874  1.000 11.25221 ? 285 ALA A CA  1 
ATOM   2222 C C   . ALA A 1 204 ? 33.14943  -17.98412 -5.96975  1.000 11.02951 ? 285 ALA A C   1 
ATOM   2223 O O   . ALA A 1 204 ? 32.29908  -18.88797 -5.91971  1.000 12.36921 ? 285 ALA A O   1 
ATOM   2224 C CB  . ALA A 1 204 ? 31.39729  -16.26782 -6.55307  1.000 11.60888 ? 285 ALA A CB  1 
ATOM   2225 N N   . GLY A 1 205 ? 34.44183  -18.22980 -6.18174  1.000 11.51205 ? 286 GLY A N   1 
ATOM   2226 C CA  . GLY A 1 205 ? 34.94267  -19.58557 -6.18245  1.000 11.92474 ? 286 GLY A CA  1 
ATOM   2227 C C   . GLY A 1 205 ? 34.78605  -20.34146 -7.47715  1.000 9.40841  ? 286 GLY A C   1 
ATOM   2228 O O   . GLY A 1 205 ? 34.97787  -21.55922 -7.47240  1.000 11.47812 ? 286 GLY A O   1 
ATOM   2229 N N   . LYS A 1 206 ? 34.45985  -19.67244 -8.58303  1.000 10.10449 ? 287 LYS A N   1 
ATOM   2230 C CA  . LYS A 1 206 ? 34.35310  -20.33541 -9.87507  1.000 10.68330 ? 287 LYS A CA  1 
ATOM   2231 C C   . LYS A 1 206 ? 33.33758  -21.47542 -9.83852  1.000 10.26232 ? 287 LYS A C   1 
ATOM   2232 O O   . LYS A 1 206 ? 33.47909  -22.46858 -10.55011 1.000 11.30326 ? 287 LYS A O   1 
ATOM   2233 C CB  . LYS A 1 206 ? 35.71923  -20.84223 -10.34888 1.000 11.55696 ? 287 LYS A CB  1 
ATOM   2234 C CG  . LYS A 1 206 ? 36.78201  -19.76016 -10.44219 1.000 11.78537 ? 287 LYS A CG  1 
ATOM   2235 C CD  . LYS A 1 206 ? 38.08504  -20.31595 -10.97446 1.000 13.26678 ? 287 LYS A CD  1 
ATOM   2236 C CE  . LYS A 1 206 ? 39.17726  -19.24404 -11.00416 1.000 15.02898 ? 287 LYS A CE  1 
ATOM   2237 N NZ  . LYS A 1 206 ? 40.49096  -19.77811 -11.49578 1.000 15.89446 ? 287 LYS A NZ  1 
ATOM   2238 N N   . SER A 1 207 ? 32.30731  -21.35874 -9.01365  1.000 9.89572  ? 288 SER A N   1 
ATOM   2239 C CA  . SER A 1 207 ? 31.35970  -22.45481 -8.85725  1.000 10.45021 ? 288 SER A CA  1 
ATOM   2240 C C   . SER A 1 207 ? 30.77426  -22.84227 -10.21077 1.000 10.12605 ? 288 SER A C   1 
ATOM   2241 O O   . SER A 1 207 ? 30.39606  -21.96474 -10.99416 1.000 9.84277  ? 288 SER A O   1 
ATOM   2242 C CB  . SER A 1 207 ? 30.20185  -22.03771 -7.95155  1.000 11.82735 ? 288 SER A CB  1 
ATOM   2243 O OG  . SER A 1 207 ? 29.17369  -23.02256 -8.02235  1.000 10.88474 ? 288 SER A OG  1 
ATOM   2244 N N   . PRO A 1 208 ? 30.65628  -24.13567 -10.50830 1.000 9.69838  ? 289 PRO A N   1 
ATOM   2245 C CA  A PRO A 1 208 ? 30.01210  -24.54808 -11.76804 0.449 9.98702  ? 289 PRO A CA  1 
ATOM   2246 C CA  B PRO A 1 208 ? 30.02004  -24.52980 -11.77577 0.551 9.95756  ? 289 PRO A CA  1 
ATOM   2247 C C   . PRO A 1 208 ? 28.56901  -24.10100 -11.88764 1.000 9.43645  ? 289 PRO A C   1 
ATOM   2248 O O   . PRO A 1 208 ? 28.03406  -24.06709 -13.00557 1.000 10.48074 ? 289 PRO A O   1 
ATOM   2249 C CB  A PRO A 1 208 ? 30.12115  -26.08271 -11.74693 0.449 12.12584 ? 289 PRO A CB  1 
ATOM   2250 C CB  B PRO A 1 208 ? 30.16175  -26.05907 -11.78998 0.551 12.16272 ? 289 PRO A CB  1 
ATOM   2251 C CG  A PRO A 1 208 ? 31.23595  -26.38338 -10.79658 0.449 11.87898 ? 289 PRO A CG  1 
ATOM   2252 C CG  B PRO A 1 208 ? 30.36707  -26.41534 -10.36510 0.551 11.96701 ? 289 PRO A CG  1 
ATOM   2253 C CD  A PRO A 1 208 ? 31.22689  -25.28035 -9.77214  0.449 11.20075 ? 289 PRO A CD  1 
ATOM   2254 C CD  B PRO A 1 208 ? 31.15043  -25.30369 -9.76078  0.551 11.20795 ? 289 PRO A CD  1 
ATOM   2255 N N   . PHE A 1 209 ? 27.91538  -23.77376 -10.77059 1.000 8.69404  ? 290 PHE A N   1 
ATOM   2256 C CA  . PHE A 1 209 ? 26.55712  -23.25007 -10.82515 1.000 9.45836  ? 290 PHE A CA  1 
ATOM   2257 C C   . PHE A 1 209 ? 26.49569  -21.83797 -11.38639 1.000 9.70503  ? 290 PHE A C   1 
ATOM   2258 O O   . PHE A 1 209 ? 25.40253  -21.39440 -11.76640 1.000 10.01177 ? 290 PHE A O   1 
ATOM   2259 C CB  . PHE A 1 209 ? 25.90795  -23.30566 -9.44795  1.000 9.35344  ? 290 PHE A CB  1 
ATOM   2260 C CG  . PHE A 1 209 ? 25.68601  -24.69958 -8.96690  1.000 9.25124  ? 290 PHE A CG  1 
ATOM   2261 C CD1 . PHE A 1 209 ? 24.73594  -25.52311 -9.56063  1.000 10.51873 ? 290 PHE A CD1 1 
ATOM   2262 C CD2 . PHE A 1 209 ? 26.45802  -25.22305 -7.94448  1.000 10.32246 ? 290 PHE A CD2 1 
ATOM   2263 C CE1 . PHE A 1 209 ? 24.56296  -26.83104 -9.12093  1.000 10.75942 ? 290 PHE A CE1 1 
ATOM   2264 C CE2 . PHE A 1 209 ? 26.27741  -26.53098 -7.51693  1.000 12.36948 ? 290 PHE A CE2 1 
ATOM   2265 C CZ  . PHE A 1 209 ? 25.33006  -27.31979 -8.10821  1.000 11.35978 ? 290 PHE A CZ  1 
ATOM   2266 N N   . ILE A 1 210 ? 27.62114  -21.12207 -11.42665 1.000 8.98381  ? 291 ILE A N   1 
ATOM   2267 C CA  . ILE A 1 210 ? 27.66983  -19.81431 -12.06700 1.000 9.48872  ? 291 ILE A CA  1 
ATOM   2268 C C   . ILE A 1 210 ? 27.84769  -20.05790 -13.55928 1.000 9.02536  ? 291 ILE A C   1 
ATOM   2269 O O   . ILE A 1 210 ? 28.97402  -20.17012 -14.06982 1.000 9.92062  ? 291 ILE A O   1 
ATOM   2270 C CB  . ILE A 1 210 ? 28.77148  -18.91574 -11.48432 1.000 10.29721 ? 291 ILE A CB  1 
ATOM   2271 C CG1 . ILE A 1 210 ? 28.64034  -18.81967 -9.96458  1.000 10.97643 ? 291 ILE A CG1 1 
ATOM   2272 C CG2 . ILE A 1 210 ? 28.72300  -17.53975 -12.12553 1.000 10.89517 ? 291 ILE A CG2 1 
ATOM   2273 C CD1 . ILE A 1 210 ? 29.86551  -18.24550 -9.27321  1.000 13.61664 ? 291 ILE A CD1 1 
ATOM   2274 N N   . LYS A 1 211 ? 26.72778  -20.19652 -14.26409 1.000 9.60693  ? 292 LYS A N   1 
ATOM   2275 C CA  . LYS A 1 211 ? 26.77281  -20.69038 -15.63564 1.000 9.41469  ? 292 LYS A CA  1 
ATOM   2276 C C   . LYS A 1 211 ? 27.27416  -19.64041 -16.60166 1.000 9.12405  ? 292 LYS A C   1 
ATOM   2277 O O   . LYS A 1 211 ? 27.92348  -19.97146 -17.59808 1.000 9.55412  ? 292 LYS A O   1 
ATOM   2278 C CB  . LYS A 1 211 ? 25.39768  -21.17675 -16.07418 1.000 11.45874 ? 292 LYS A CB  1 
ATOM   2279 C CG  . LYS A 1 211 ? 24.92520  -22.38978 -15.29051 1.000 11.01293 ? 292 LYS A CG  1 
ATOM   2280 C CD  . LYS A 1 211 ? 25.73711  -23.65366 -15.59851 1.000 12.92053 ? 292 LYS A CD  1 
ATOM   2281 C CE  . LYS A 1 211 ? 25.08526  -24.51899 -16.67073 1.000 12.39040 ? 292 LYS A CE  1 
ATOM   2282 N NZ  . LYS A 1 211 ? 25.96262  -25.66105 -17.08239 1.000 15.76770 ? 292 LYS A NZ  1 
ATOM   2283 N N   . GLY A 1 212 ? 26.99036  -18.37662 -16.33225 1.000 9.83399  ? 293 GLY A N   1 
ATOM   2284 C CA  . GLY A 1 212 ? 27.34167  -17.34302 -17.27932 1.000 9.56319  ? 293 GLY A CA  1 
ATOM   2285 C C   . GLY A 1 212 ? 26.55186  -16.08250 -17.04700 1.000 9.26287  ? 293 GLY A C   1 
ATOM   2286 O O   . GLY A 1 212 ? 26.42801  -15.64238 -15.90228 1.000 9.07644  ? 293 GLY A O   1 
ATOM   2287 N N   . LEU A 1 213 ? 26.02963  -15.50778 -18.12505 1.000 8.53259  ? 294 LEU A N   1 
ATOM   2288 C CA  . LEU A 1 213 ? 25.50502  -14.15124 -18.13301 1.000 8.12022  ? 294 LEU A CA  1 
ATOM   2289 C C   . LEU A 1 213 ? 24.12820  -14.11043 -18.77204 1.000 8.47601  ? 294 LEU A C   1 
ATOM   2290 O O   . LEU A 1 213 ? 23.80835  -14.91887 -19.64709 1.000 9.02394  ? 294 LEU A O   1 
ATOM   2291 C CB  . LEU A 1 213 ? 26.43790  -13.22067 -18.90944 1.000 9.24207  ? 294 LEU A CB  1 
ATOM   2292 C CG  . LEU A 1 213 ? 27.88544  -13.15479 -18.42949 1.000 10.48197 ? 294 LEU A CG  1 
ATOM   2293 C CD1 . LEU A 1 213 ? 28.71053  -12.23323 -19.32113 1.000 11.12596 ? 294 LEU A CD1 1 
ATOM   2294 C CD2 . LEU A 1 213 ? 27.97429  -12.71087 -16.98470 1.000 12.77608 ? 294 LEU A CD2 1 
ATOM   2295 N N   . ALA A 1 214 ? 23.32687  -13.14512 -18.33389 1.000 8.29724  ? 295 ALA A N   1 
ATOM   2296 C CA  . ALA A 1 214 ? 22.02291  -12.87154 -18.91905 1.000 8.55701  ? 295 ALA A CA  1 
ATOM   2297 C C   . ALA A 1 214 ? 22.09755  -11.52732 -19.62451 1.000 8.73245  ? 295 ALA A C   1 
ATOM   2298 O O   . ALA A 1 214 ? 22.65080  -10.57246 -19.07240 1.000 9.52746  ? 295 ALA A O   1 
ATOM   2299 C CB  . ALA A 1 214 ? 20.94443  -12.81012 -17.83376 1.000 9.81513  ? 295 ALA A CB  1 
ATOM   2300 N N   . THR A 1 215 ? 21.57458  -11.44803 -20.84335 1.000 8.34877  ? 296 THR A N   1 
ATOM   2301 C CA  . THR A 1 215 ? 21.62486  -10.20194 -21.59487 1.000 8.62233  ? 296 THR A CA  1 
ATOM   2302 C C   . THR A 1 215 ? 20.22781  -9.78157  -22.03631 1.000 8.60036  ? 296 THR A C   1 
ATOM   2303 O O   . THR A 1 215 ? 19.27980  -10.57901 -22.09182 1.000 9.08333  ? 296 THR A O   1 
ATOM   2304 C CB  . THR A 1 215 ? 22.57030  -10.25892 -22.81042 1.000 9.15169  ? 296 THR A CB  1 
ATOM   2305 O OG1 . THR A 1 215 ? 21.91000  -10.88490 -23.91625 1.000 10.38029 ? 296 THR A OG1 1 
ATOM   2306 C CG2 . THR A 1 215 ? 23.85247  -10.99549 -22.47731 1.000 10.30182 ? 296 THR A CG2 1 
ATOM   2307 N N   . ASN A 1 216 ? 20.12026  -8.48599  -22.34194 1.000 8.49267  ? 297 ASN A N   1 
ATOM   2308 C CA  . ASN A 1 216 ? 18.90221  -7.84706  -22.83034 1.000 8.87817  ? 297 ASN A CA  1 
ATOM   2309 C C   . ASN A 1 216 ? 17.77066  -7.85741  -21.81140 1.000 9.40701  ? 297 ASN A C   1 
ATOM   2310 O O   . ASN A 1 216 ? 16.61235  -7.62240  -22.18715 1.000 8.84233  ? 297 ASN A O   1 
ATOM   2311 C CB  . ASN A 1 216 ? 18.45330  -8.43298  -24.17310 1.000 9.35599  ? 297 ASN A CB  1 
ATOM   2312 C CG  . ASN A 1 216 ? 17.59386  -7.48349  -24.97829 1.000 9.12962  ? 297 ASN A CG  1 
ATOM   2313 O OD1 . ASN A 1 216 ? 17.96945  -6.33575  -25.20759 1.000 9.90859  ? 297 ASN A OD1 1 
ATOM   2314 N ND2 . ASN A 1 216 ? 16.43773  -7.95824  -25.42683 1.000 10.95470 ? 297 ASN A ND2 1 
ATOM   2315 N N   . VAL A 1 217 ? 18.07914  -8.09511  -20.52593 1.000 9.25855  ? 298 VAL A N   1 
ATOM   2316 C CA  . VAL A 1 217 ? 17.03637  -8.14470  -19.50245 1.000 8.80433  ? 298 VAL A CA  1 
ATOM   2317 C C   . VAL A 1 217 ? 16.29973  -6.81765  -19.46625 1.000 9.71018  ? 298 VAL A C   1 
ATOM   2318 O O   . VAL A 1 217 ? 16.90810  -5.74714  -19.31951 1.000 9.51158  ? 298 VAL A O   1 
ATOM   2319 C CB  . VAL A 1 217 ? 17.63845  -8.48787  -18.13048 1.000 8.51475  ? 298 VAL A CB  1 
ATOM   2320 C CG1 . VAL A 1 217 ? 16.56380  -8.38953  -17.05223 1.000 9.32720  ? 298 VAL A CG1 1 
ATOM   2321 C CG2 . VAL A 1 217 ? 18.25232  -9.87396  -18.14731 1.000 10.38658 ? 298 VAL A CG2 1 
ATOM   2322 N N   . ALA A 1 218 ? 14.97344  -6.88063  -19.57590 1.000 9.46980  ? 299 ALA A N   1 
ATOM   2323 C CA  . ALA A 1 218 ? 14.11834  -5.69639  -19.55329 1.000 10.18338 ? 299 ALA A CA  1 
ATOM   2324 C C   . ALA A 1 218 ? 14.39590  -4.74850  -20.70274 1.000 9.40981  ? 299 ALA A C   1 
ATOM   2325 O O   . ALA A 1 218 ? 13.95208  -3.59140  -20.68148 1.000 11.00037 ? 299 ALA A O   1 
ATOM   2326 C CB  . ALA A 1 218 ? 14.16448  -4.97434  -18.20733 1.000 10.70829 ? 299 ALA A CB  1 
ATOM   2327 N N   . ASN A 1 219 ? 15.08017  -5.22017  -21.73579 1.000 9.58117  ? 300 ASN A N   1 
ATOM   2328 C CA  . ASN A 1 219 ? 15.37684  -4.39640  -22.88260 1.000 9.78446  ? 300 ASN A CA  1 
ATOM   2329 C C   . ASN A 1 219 ? 14.64988  -4.93532  -24.12228 1.000 9.28036  ? 300 ASN A C   1 
ATOM   2330 O O   . ASN A 1 219 ? 13.70401  -5.72857  -24.00842 1.000 9.64567  ? 300 ASN A O   1 
ATOM   2331 C CB  . ASN A 1 219 ? 16.89690  -4.19201  -23.02515 1.000 10.87650 ? 300 ASN A CB  1 
ATOM   2332 C CG  . ASN A 1 219 ? 17.23842  -2.86116  -23.66573 1.000 11.15769 ? 300 ASN A CG  1 
ATOM   2333 O OD1 . ASN A 1 219 ? 17.13441  -2.70962  -24.87740 1.000 11.65223 ? 300 ASN A OD1 1 
ATOM   2334 N ND2 . ASN A 1 219 ? 17.62404  -1.88176  -22.84903 1.000 12.77666 ? 300 ASN A ND2 1 
ATOM   2335 N N   . TYR A 1 220 ? 15.07221  -4.47725  -25.29868 1.000 9.60107  ? 301 TYR A N   1 
ATOM   2336 C CA  . TYR A 1 220 ? 14.26606  -4.58528  -26.50516 1.000 9.84893  ? 301 TYR A CA  1 
ATOM   2337 C C   . TYR A 1 220 ? 15.10448  -4.96015  -27.71255 1.000 9.41063  ? 301 TYR A C   1 
ATOM   2338 O O   . TYR A 1 220 ? 14.57812  -4.96378  -28.83268 1.000 10.36536 ? 301 TYR A O   1 
ATOM   2339 C CB  . TYR A 1 220 ? 13.53168  -3.26312  -26.80517 1.000 10.61058 ? 301 TYR A CB  1 
ATOM   2340 C CG  . TYR A 1 220 ? 12.83904  -2.60719  -25.62240 1.000 11.07751 ? 301 TYR A CG  1 
ATOM   2341 C CD1 . TYR A 1 220 ? 13.53115  -1.77255  -24.74346 1.000 10.78257 ? 301 TYR A CD1 1 
ATOM   2342 C CD2 . TYR A 1 220 ? 11.48562  -2.79955  -25.39678 1.000 10.98018 ? 301 TYR A CD2 1 
ATOM   2343 C CE1 . TYR A 1 220 ? 12.89388  -1.16780  -23.67707 1.000 11.96369 ? 301 TYR A CE1 1 
ATOM   2344 C CE2 . TYR A 1 220 ? 10.84090  -2.19025  -24.33285 1.000 10.58559 ? 301 TYR A CE2 1 
ATOM   2345 C CZ  . TYR A 1 220 ? 11.54505  -1.36970  -23.48452 1.000 10.84241 ? 301 TYR A CZ  1 
ATOM   2346 O OH  . TYR A 1 220 ? 10.89160  -0.74709  -22.43995 1.000 12.62296 ? 301 TYR A OH  1 
ATOM   2347 N N   . ASN A 1 221 ? 16.37954  -5.28553  -27.52951 1.000 9.05662  ? 302 ASN A N   1 
ATOM   2348 C CA  . ASN A 1 221 ? 17.24687  -5.55634  -28.66720 1.000 9.40581  ? 302 ASN A CA  1 
ATOM   2349 C C   . ASN A 1 221 ? 16.84049  -6.85599  -29.34760 1.000 9.66818  ? 302 ASN A C   1 
ATOM   2350 O O   . ASN A 1 221 ? 16.29458  -7.77725  -28.72431 1.000 10.38133 ? 302 ASN A O   1 
ATOM   2351 C CB  . ASN A 1 221 ? 18.69920  -5.72676  -28.22593 1.000 9.78395  ? 302 ASN A CB  1 
ATOM   2352 C CG  . ASN A 1 221 ? 19.33710  -4.43061  -27.76493 1.000 9.71072  ? 302 ASN A CG  1 
ATOM   2353 O OD1 . ASN A 1 221 ? 18.78378  -3.33386  -27.90415 1.000 10.65821 ? 302 ASN A OD1 1 
ATOM   2354 N ND2 . ASN A 1 221 ? 20.53304  -4.55287  -27.22458 1.000 11.21267 ? 302 ASN A ND2 1 
ATOM   2355 N N   . ALA A 1 222 ? 17.15073  -6.94708  -30.63795 1.000 10.67547 ? 303 ALA A N   1 
ATOM   2356 C CA  . ALA A 1 222 ? 17.02920  -8.21701  -31.33477 1.000 11.00611 ? 303 ALA A CA  1 
ATOM   2357 C C   . ALA A 1 222 ? 18.10529  -9.17527  -30.84645 1.000 10.05458 ? 303 ALA A C   1 
ATOM   2358 O O   . ALA A 1 222 ? 19.21949  -8.76532  -30.50645 1.000 11.05083 ? 303 ALA A O   1 
ATOM   2359 C CB  . ALA A 1 222 ? 17.21561  -8.01851  -32.84176 1.000 12.60266 ? 303 ALA A CB  1 
ATOM   2360 N N   . LEU A 1 223 ? 17.77229  -10.46580 -30.82087 1.000 10.57294 ? 304 LEU A N   1 
ATOM   2361 C CA  . LEU A 1 223 ? 18.82212  -11.47472 -30.75183 1.000 10.65924 ? 304 LEU A CA  1 
ATOM   2362 C C   . LEU A 1 223 ? 19.59916  -11.51773 -32.06266 1.000 10.71509 ? 304 LEU A C   1 
ATOM   2363 O O   . LEU A 1 223 ? 20.83533  -11.42110 -32.07226 1.000 11.65941 ? 304 LEU A O   1 
ATOM   2364 C CB  . LEU A 1 223 ? 18.22341  -12.83869 -30.40554 1.000 12.83312 ? 304 LEU A CB  1 
ATOM   2365 C CG  . LEU A 1 223 ? 19.19394  -14.02482 -30.40043 1.000 11.38985 ? 304 LEU A CG  1 
ATOM   2366 C CD1 . LEU A 1 223 ? 20.39526  -13.78160 -29.51316 1.000 12.89907 ? 304 LEU A CD1 1 
ATOM   2367 C CD2 . LEU A 1 223 ? 18.45273  -15.28497 -29.97294 1.000 13.90943 ? 304 LEU A CD2 1 
ATOM   2368 N N   A GLN A 1 224 ? 18.89399  -11.67346 -33.18241 0.622 12.97995 ? 305 GLN A N   1 
ATOM   2369 N N   B GLN A 1 224 ? 18.88836  -11.65250 -33.18137 0.378 13.04894 ? 305 GLN A N   1 
ATOM   2370 C CA  A GLN A 1 224 ? 19.50508  -11.66737 -34.51285 0.622 13.48528 ? 305 GLN A CA  1 
ATOM   2371 C CA  B GLN A 1 224 ? 19.49213  -11.67924 -34.50852 0.378 13.56061 ? 305 GLN A CA  1 
ATOM   2372 C C   A GLN A 1 224 ? 18.66894  -10.74298 -35.39186 0.622 15.32115 ? 305 GLN A C   1 
ATOM   2373 C C   B GLN A 1 224 ? 18.72119  -10.72471 -35.40753 0.378 15.22756 ? 305 GLN A C   1 
ATOM   2374 O O   A GLN A 1 224 ? 17.57928  -11.11645 -35.84392 0.622 16.25112 ? 305 GLN A O   1 
ATOM   2375 O O   B GLN A 1 224 ? 17.51394  -10.89913 -35.61838 0.378 15.47730 ? 305 GLN A O   1 
ATOM   2376 C CB  A GLN A 1 224 ? 19.58267  -13.06966 -35.10662 0.622 17.78206 ? 305 GLN A CB  1 
ATOM   2377 C CB  B GLN A 1 224 ? 19.47950  -13.09372 -35.09396 0.378 17.72573 ? 305 GLN A CB  1 
ATOM   2378 C CG  A GLN A 1 224 ? 20.41141  -13.14176 -36.38060 0.622 21.16267 ? 305 GLN A CG  1 
ATOM   2379 C CG  B GLN A 1 224 ? 20.38401  -14.05937 -34.35492 0.378 15.55207 ? 305 GLN A CG  1 
ATOM   2380 C CD  A GLN A 1 224 ? 21.00073  -14.51531 -36.61778 0.622 24.85015 ? 305 GLN A CD  1 
ATOM   2381 C CD  B GLN A 1 224 ? 20.72485  -15.28874 -35.16965 0.378 20.22122 ? 305 GLN A CD  1 
ATOM   2382 O OE1 A GLN A 1 224 ? 22.21487  -14.70833 -36.53779 0.622 30.57223 ? 305 GLN A OE1 1 
ATOM   2383 O OE1 B GLN A 1 224 ? 21.56394  -15.22882 -36.06643 0.378 20.15997 ? 305 GLN A OE1 1 
ATOM   2384 N NE2 A GLN A 1 224 ? 20.13833  -15.48253 -36.91768 0.622 31.78118 ? 305 GLN A NE2 1 
ATOM   2385 N NE2 B GLN A 1 224 ? 20.08688  -16.41407 -34.85531 0.378 20.25907 ? 305 GLN A NE2 1 
ATOM   2386 N N   A ALA A 1 225 ? 19.17983  -9.53715  -35.62555 0.622 13.29036 ? 306 ALA A N   1 
ATOM   2387 N N   B ALA A 1 225 ? 19.41269  -9.71702  -35.92875 0.378 14.92866 ? 306 ALA A N   1 
ATOM   2388 C CA  A ALA A 1 225 ? 18.44245  -8.51478  -36.35512 0.622 14.16545 ? 306 ALA A CA  1 
ATOM   2389 C CA  B ALA A 1 225 ? 18.80461  -8.69073  -36.76220 0.378 16.17655 ? 306 ALA A CA  1 
ATOM   2390 C C   A ALA A 1 225 ? 18.53232  -8.75155  -37.85591 0.622 14.90846 ? 306 ALA A C   1 
ATOM   2391 C C   B ALA A 1 225 ? 19.38748  -8.76714  -38.16574 0.378 16.36080 ? 306 ALA A C   1 
ATOM   2392 O O   A ALA A 1 225 ? 19.58042  -9.14861  -38.37202 0.622 16.36253 ? 306 ALA A O   1 
ATOM   2393 O O   B ALA A 1 225 ? 20.61087  -8.73706  -38.33773 0.378 14.69571 ? 306 ALA A O   1 
ATOM   2394 C CB  A ALA A 1 225 ? 19.01851  -7.13720  -36.03006 0.622 16.43688 ? 306 ALA A CB  1 
ATOM   2395 C CB  B ALA A 1 225 ? 19.05521  -7.30309  -36.16939 0.378 16.35252 ? 306 ALA A CB  1 
ATOM   2396 N N   A ALA A 1 226 ? 17.42124  -8.49570  -38.55670 0.622 16.83155 ? 307 ALA A N   1 
ATOM   2397 N N   B ALA A 1 226 ? 18.50902  -8.87168  -39.16609 0.378 17.03631 ? 307 ALA A N   1 
ATOM   2398 C CA  A ALA A 1 226 ? 17.42266  -8.58991  -40.01472 0.622 19.17430 ? 307 ALA A CA  1 
ATOM   2399 C CA  B ALA A 1 226 ? 18.96955  -8.86628  -40.54977 0.378 17.81636 ? 307 ALA A CA  1 
ATOM   2400 C C   A ALA A 1 226 ? 18.34605  -7.54554  -40.63066 0.622 18.37124 ? 307 ALA A C   1 
ATOM   2401 C C   B ALA A 1 226 ? 19.44203  -7.48254  -40.96591 0.378 19.75768 ? 307 ALA A C   1 
ATOM   2402 O O   A ALA A 1 226 ? 19.01681  -7.80309  -41.63718 0.622 20.65403 ? 307 ALA A O   1 
ATOM   2403 O O   B ALA A 1 226 ? 20.30693  -7.35703  -41.84006 0.378 22.62565 ? 307 ALA A O   1 
ATOM   2404 C CB  A ALA A 1 226 ? 16.00049  -8.42690  -40.54553 0.622 23.78368 ? 307 ALA A CB  1 
ATOM   2405 C CB  B ALA A 1 226 ? 17.85494  -9.34854  -41.47842 0.378 20.94659 ? 307 ALA A CB  1 
ATOM   2406 N N   A SER A 1 227 ? 18.37753  -6.35532  -40.04771 0.622 17.55007 ? 308 SER A N   1 
ATOM   2407 N N   B SER A 1 227 ? 18.88593  -6.44050  -40.35258 0.378 15.36886 ? 308 SER A N   1 
ATOM   2408 C CA  A SER A 1 227 ? 19.31369  -5.30220  -40.41184 0.622 17.82895 ? 308 SER A CA  1 
ATOM   2409 C CA  B SER A 1 227 ? 19.27418  -5.06854  -40.61190 0.378 17.96703 ? 308 SER A CA  1 
ATOM   2410 C C   A SER A 1 227 ? 19.48458  -4.41083  -39.19584 0.622 15.46640 ? 308 SER A C   1 
ATOM   2411 C C   B SER A 1 227 ? 19.47126  -4.36288  -39.27606 0.378 15.56052 ? 308 SER A C   1 
ATOM   2412 O O   A SER A 1 227 ? 18.61062  -4.38929  -38.32116 0.622 15.92933 ? 308 SER A O   1 
ATOM   2413 O O   B SER A 1 227 ? 18.60165  -4.44672  -38.38998 0.378 16.00644 ? 308 SER A O   1 
ATOM   2414 C CB  A SER A 1 227 ? 18.79100  -4.48315  -41.59922 0.622 20.25802 ? 308 SER A CB  1 
ATOM   2415 C CB  B SER A 1 227 ? 18.22400  -4.33798  -41.45633 0.378 22.23963 ? 308 SER A CB  1 
ATOM   2416 O OG  A SER A 1 227 ? 17.56318  -3.85719  -41.27649 0.622 23.08222 ? 308 SER A OG  1 
ATOM   2417 O OG  B SER A 1 227 ? 17.21276  -3.77249  -40.64293 0.378 23.52513 ? 308 SER A OG  1 
ATOM   2418 N N   . PRO A 1 228 ? 20.59428  -3.67982  -39.09090 1.000 14.87949 ? 309 PRO A N   1 
ATOM   2419 C CA  . PRO A 1 228 ? 20.85050  -2.96776  -37.83320 1.000 15.16849 ? 309 PRO A CA  1 
ATOM   2420 C C   . PRO A 1 228 ? 19.81850  -1.88357  -37.56944 1.000 13.46550 ? 309 PRO A C   1 
ATOM   2421 O O   . PRO A 1 228 ? 19.43861  -1.13136  -38.46742 1.000 14.17484 ? 309 PRO A O   1 
ATOM   2422 C CB  . PRO A 1 228 ? 22.24395  -2.36640  -38.05074 1.000 15.44678 ? 309 PRO A CB  1 
ATOM   2423 C CG  . PRO A 1 228 ? 22.88556  -3.24979  -39.07082 1.000 18.77957 ? 309 PRO A CG  1 
ATOM   2424 C CD  . PRO A 1 228 ? 21.75459  -3.61803  -39.99722 1.000 18.03982 ? 309 PRO A CD  1 
ATOM   2425 N N   . ASP A 1 229 ? 19.37439  -1.80888  -36.32208 1.000 11.95993 ? 310 ASP A N   1 
ATOM   2426 C CA  . ASP A 1 229 ? 18.52061  -0.71151  -35.89270 1.000 11.52794 ? 310 ASP A CA  1 
ATOM   2427 C C   . ASP A 1 229 ? 19.32799  0.58848   -35.97267 1.000 12.55328 ? 310 ASP A C   1 
ATOM   2428 O O   . ASP A 1 229 ? 20.49618  0.60539   -35.56901 1.000 12.67576 ? 310 ASP A O   1 
ATOM   2429 C CB  . ASP A 1 229 ? 18.10865  -1.03051  -34.44983 1.000 12.00989 ? 310 ASP A CB  1 
ATOM   2430 C CG  . ASP A 1 229 ? 17.02701  -0.11453  -33.89358 1.000 12.05209 ? 310 ASP A CG  1 
ATOM   2431 O OD1 . ASP A 1 229 ? 17.10114  1.11152   -34.13048 1.000 13.04446 ? 310 ASP A OD1 1 
ATOM   2432 O OD2 . ASP A 1 229 ? 16.13715  -0.62857  -33.15529 1.000 12.34798 ? 310 ASP A OD2 1 
ATOM   2433 N N   . PRO A 1 230 ? 18.76819  1.67958   -36.51098 1.000 12.46230 ? 311 PRO A N   1 
ATOM   2434 C CA  A PRO A 1 230 ? 19.53697  2.92990   -36.61260 0.677 13.26471 ? 311 PRO A CA  1 
ATOM   2435 C CA  B PRO A 1 230 ? 19.56305  2.91458   -36.61995 0.323 13.26321 ? 311 PRO A CA  1 
ATOM   2436 C C   . PRO A 1 230 ? 20.13555  3.39660   -35.30084 1.000 11.65665 ? 311 PRO A C   1 
ATOM   2437 O O   . PRO A 1 230 ? 21.13196  4.12798   -35.31476 1.000 12.76157 ? 311 PRO A O   1 
ATOM   2438 C CB  A PRO A 1 230 ? 18.50028  3.92923   -37.13877 0.677 16.19633 ? 311 PRO A CB  1 
ATOM   2439 C CB  B PRO A 1 230 ? 18.57380  3.92535   -37.21999 0.323 16.15066 ? 311 PRO A CB  1 
ATOM   2440 C CG  A PRO A 1 230 ? 17.54913  3.09131   -37.92245 0.677 14.33454 ? 311 PRO A CG  1 
ATOM   2441 C CG  B PRO A 1 230 ? 17.22771  3.34722   -36.93626 0.323 12.55767 ? 311 PRO A CG  1 
ATOM   2442 C CD  A PRO A 1 230 ? 17.46689  1.76851   -37.20250 0.677 12.88759 ? 311 PRO A CD  1 
ATOM   2443 C CD  B PRO A 1 230 ? 17.41732  1.86617   -37.06812 0.323 12.61866 ? 311 PRO A CD  1 
ATOM   2444 N N   . ILE A 1 231 ? 19.55090  3.01457   -34.16189 1.000 12.60108 ? 312 ILE A N   1 
ATOM   2445 C CA  . ILE A 1 231 ? 20.10858  3.42503   -32.88070 1.000 11.71925 ? 312 ILE A CA  1 
ATOM   2446 C C   . ILE A 1 231 ? 21.50750  2.88803   -32.64747 1.000 10.32869 ? 312 ILE A C   1 
ATOM   2447 O O   . ILE A 1 231 ? 22.20417  3.38466   -31.75526 1.000 11.89990 ? 312 ILE A O   1 
ATOM   2448 C CB  . ILE A 1 231 ? 19.19202  3.02201   -31.70546 1.000 13.01028 ? 312 ILE A CB  1 
ATOM   2449 C CG1 . ILE A 1 231 ? 19.12074  1.49682   -31.56045 1.000 12.70930 ? 312 ILE A CG1 1 
ATOM   2450 C CG2 . ILE A 1 231 ? 17.81202  3.65332   -31.85268 1.000 14.00702 ? 312 ILE A CG2 1 
ATOM   2451 C CD1 . ILE A 1 231 ? 17.99885  1.00371   -30.65005 1.000 13.02006 ? 312 ILE A CD1 1 
ATOM   2452 N N   . THR A 1 232 ? 21.92830  1.87922   -33.40677 1.000 10.82545 ? 313 THR A N   1 
ATOM   2453 C CA  . THR A 1 232 ? 23.16671  1.16427   -33.15423 1.000 10.58667 ? 313 THR A CA  1 
ATOM   2454 C C   . THR A 1 232 ? 24.36391  1.72825   -33.91010 1.000 11.01543 ? 313 THR A C   1 
ATOM   2455 O O   . THR A 1 232 ? 25.45232  1.16828   -33.79137 1.000 11.73332 ? 313 THR A O   1 
ATOM   2456 C CB  . THR A 1 232 ? 23.01175  -0.32449  -33.49924 1.000 11.17896 ? 313 THR A CB  1 
ATOM   2457 O OG1 . THR A 1 232 ? 22.91516  -0.48797  -34.92572 1.000 12.33666 ? 313 THR A OG1 1 
ATOM   2458 C CG2 . THR A 1 232 ? 21.79728  -0.93378  -32.80583 1.000 12.21844 ? 313 THR A CG2 1 
ATOM   2459 N N   A GLN A 1 233 ? 24.19751  2.82922   -34.65064 0.813 10.82297 ? 314 GLN A N   1 
ATOM   2460 N N   B GLN A 1 233 ? 24.19313  2.82743   -34.64798 0.187 10.94578 ? 314 GLN A N   1 
ATOM   2461 C CA  A GLN A 1 233 ? 25.27647  3.30612   -35.50916 0.813 11.82774 ? 314 GLN A CA  1 
ATOM   2462 C CA  B GLN A 1 233 ? 25.26634  3.40037   -35.45812 0.187 11.87168 ? 314 GLN A CA  1 
ATOM   2463 C C   A GLN A 1 233 ? 26.53916  3.54553   -34.70296 0.813 11.00581 ? 314 GLN A C   1 
ATOM   2464 C C   B GLN A 1 233 ? 26.55378  3.54445   -34.65721 0.187 11.11303 ? 314 GLN A C   1 
ATOM   2465 O O   A GLN A 1 233 ? 26.50798  4.18590   -33.65171 0.813 11.39410 ? 314 GLN A O   1 
ATOM   2466 O O   B GLN A 1 233 ? 26.55679  4.10497   -33.55815 0.187 11.58865 ? 314 GLN A O   1 
ATOM   2467 C CB  A GLN A 1 233 ? 24.88320  4.60652   -36.19015 0.813 12.39165 ? 314 GLN A CB  1 
ATOM   2468 C CB  B GLN A 1 233 ? 24.82997  4.78147   -35.94130 0.187 12.88314 ? 314 GLN A CB  1 
ATOM   2469 C CG  A GLN A 1 233 ? 23.76097  4.48772   -37.17631 0.813 14.48065 ? 314 GLN A CG  1 
ATOM   2470 C CG  B GLN A 1 233 ? 23.66983  4.78100   -36.91032 0.187 15.35113 ? 314 GLN A CG  1 
ATOM   2471 C CD  A GLN A 1 233 ? 23.22910  5.85687   -37.55444 0.813 16.84369 ? 314 GLN A CD  1 
ATOM   2472 C CD  B GLN A 1 233 ? 23.79364  5.86687   -37.95207 0.187 18.48781 ? 314 GLN A CD  1 
ATOM   2473 O OE1 A GLN A 1 233 ? 23.91204  6.62511   -38.23134 0.813 17.28773 ? 314 GLN A OE1 1 
ATOM   2474 O OE1 B GLN A 1 233 ? 24.53551  6.83192   -37.76813 0.187 16.24537 ? 314 GLN A OE1 1 
ATOM   2475 N NE2 A GLN A 1 233 ? 22.03313  6.19394   -37.07601 0.813 14.22808 ? 314 GLN A NE2 1 
ATOM   2476 N NE2 B GLN A 1 233 ? 23.06856  5.71919   -39.05493 0.187 22.40915 ? 314 GLN A NE2 1 
ATOM   2477 N N   . GLY A 1 234 ? 27.65670  3.04231   -35.21735 1.000 12.07317 ? 315 GLY A N   1 
ATOM   2478 C CA  . GLY A 1 234 ? 28.93679  3.11571   -34.56882 1.000 12.02978 ? 315 GLY A CA  1 
ATOM   2479 C C   . GLY A 1 234 ? 29.35011  1.84447   -33.85410 1.000 11.31491 ? 315 GLY A C   1 
ATOM   2480 O O   . GLY A 1 234 ? 30.53395  1.69121   -33.53475 1.000 11.45767 ? 315 GLY A O   1 
ATOM   2481 N N   . ASN A 1 235 ? 28.39865  0.94787   -33.57748 1.000 11.63274 ? 316 ASN A N   1 
ATOM   2482 C CA  . ASN A 1 235 ? 28.64398  -0.29785  -32.85817 1.000 10.87525 ? 316 ASN A CA  1 
ATOM   2483 C C   . ASN A 1 235 ? 28.45721  -1.46226  -33.81576 1.000 11.06358 ? 316 ASN A C   1 
ATOM   2484 O O   . ASN A 1 235 ? 27.32416  -1.72714  -34.24183 1.000 11.35037 ? 316 ASN A O   1 
ATOM   2485 C CB  . ASN A 1 235 ? 27.66378  -0.42538  -31.68944 1.000 11.25191 ? 316 ASN A CB  1 
ATOM   2486 C CG  . ASN A 1 235 ? 28.00129  -1.57944  -30.76698 1.000 9.95116  ? 316 ASN A CG  1 
ATOM   2487 O OD1 . ASN A 1 235 ? 28.82372  -2.43126  -31.10070 1.000 11.24605 ? 316 ASN A OD1 1 
ATOM   2488 N ND2 . ASN A 1 235 ? 27.36654  -1.61338  -29.60318 1.000 10.91593 ? 316 ASN A ND2 1 
ATOM   2489 N N   . PRO A 1 236 ? 29.51339  -2.18856  -34.18253 1.000 11.29333 ? 317 PRO A N   1 
ATOM   2490 C CA  . PRO A 1 236 ? 29.32222  -3.35173  -35.05497 1.000 13.51113 ? 317 PRO A CA  1 
ATOM   2491 C C   . PRO A 1 236 ? 28.52411  -4.45480  -34.39372 1.000 13.00051 ? 317 PRO A C   1 
ATOM   2492 O O   . PRO A 1 236 ? 27.99053  -5.31973  -35.09835 1.000 13.95715 ? 317 PRO A O   1 
ATOM   2493 C CB  . PRO A 1 236 ? 30.75486  -3.80856  -35.35574 1.000 16.76011 ? 317 PRO A CB  1 
ATOM   2494 C CG  . PRO A 1 236 ? 31.55071  -3.32616  -34.19808 1.000 17.20449 ? 317 PRO A CG  1 
ATOM   2495 C CD  . PRO A 1 236 ? 30.91860  -2.01150  -33.78914 1.000 13.78220 ? 317 PRO A CD  1 
ATOM   2496 N N   . ASN A 1 237 ? 28.42535  -4.45654  -33.06048 1.000 11.75649 ? 318 ASN A N   1 
ATOM   2497 C CA  . ASN A 1 237 ? 27.65708  -5.47446  -32.34918 1.000 11.58413 ? 318 ASN A CA  1 
ATOM   2498 C C   . ASN A 1 237 ? 26.26172  -4.91128  -32.10974 1.000 11.83015 ? 318 ASN A C   1 
ATOM   2499 O O   . ASN A 1 237 ? 25.91851  -4.43118  -31.02905 1.000 12.14692 ? 318 ASN A O   1 
ATOM   2500 C CB  . ASN A 1 237 ? 28.38041  -5.87152  -31.07476 1.000 11.63497 ? 318 ASN A CB  1 
ATOM   2501 C CG  . ASN A 1 237 ? 29.71024  -6.49431  -31.37258 1.000 12.03540 ? 318 ASN A CG  1 
ATOM   2502 O OD1 . ASN A 1 237 ? 29.83779  -7.22840  -32.35891 1.000 13.12358 ? 318 ASN A OD1 1 
ATOM   2503 N ND2 . ASN A 1 237 ? 30.70986  -6.20569  -30.55684 1.000 12.43408 ? 318 ASN A ND2 1 
ATOM   2504 N N   . TYR A 1 238 ? 25.43975  -4.98775  -33.15480 1.000 11.95481 ? 319 TYR A N   1 
ATOM   2505 C CA  . TYR A 1 238 ? 24.15596  -4.30434  -33.19928 1.000 11.90367 ? 319 TYR A CA  1 
ATOM   2506 C C   . TYR A 1 238 ? 23.00135  -5.14476  -32.67444 1.000 12.68662 ? 319 TYR A C   1 
ATOM   2507 O O   . TYR A 1 238 ? 21.87274  -4.64916  -32.61370 1.000 12.23104 ? 319 TYR A O   1 
ATOM   2508 C CB  . TYR A 1 238 ? 23.84664  -3.80390  -34.62005 1.000 13.42229 ? 319 TYR A CB  1 
ATOM   2509 C CG  . TYR A 1 238 ? 23.93508  -4.85913  -35.68688 1.000 13.78850 ? 319 TYR A CG  1 
ATOM   2510 C CD1 . TYR A 1 238 ? 22.86956  -5.71767  -35.94149 1.000 15.14143 ? 319 TYR A CD1 1 
ATOM   2511 C CD2 . TYR A 1 238 ? 25.08319  -4.98861  -36.45481 1.000 15.86351 ? 319 TYR A CD2 1 
ATOM   2512 C CE1 . TYR A 1 238 ? 22.95045  -6.68470  -36.92979 1.000 15.91674 ? 319 TYR A CE1 1 
ATOM   2513 C CE2 . TYR A 1 238 ? 25.17755  -5.96124  -37.43585 1.000 18.16524 ? 319 TYR A CE2 1 
ATOM   2514 C CZ  . TYR A 1 238 ? 24.10896  -6.79787  -37.66727 1.000 17.92147 ? 319 TYR A CZ  1 
ATOM   2515 O OH  . TYR A 1 238 ? 24.19707  -7.76419  -38.64849 1.000 21.02099 ? 319 TYR A OH  1 
ATOM   2516 N N   . ASP A 1 239 ? 23.24792  -6.39935  -32.30553 1.000 11.18699 ? 320 ASP A N   1 
ATOM   2517 C CA  . ASP A 1 239 ? 22.22971  -7.25539  -31.72776 1.000 11.19128 ? 320 ASP A CA  1 
ATOM   2518 C C   . ASP A 1 239 ? 22.89472  -8.15096  -30.69054 1.000 10.88188 ? 320 ASP A C   1 
ATOM   2519 O O   . ASP A 1 239 ? 24.11437  -8.15441  -30.52098 1.000 10.57878 ? 320 ASP A O   1 
ATOM   2520 C CB  . ASP A 1 239 ? 21.46349  -8.04094  -32.80381 1.000 12.44668 ? 320 ASP A CB  1 
ATOM   2521 C CG  . ASP A 1 239 ? 22.38145  -8.88456  -33.68126 1.000 12.65397 ? 320 ASP A CG  1 
ATOM   2522 O OD1 . ASP A 1 239 ? 23.52437  -9.18067  -33.26690 1.000 13.16562 ? 320 ASP A OD1 1 
ATOM   2523 O OD2 . ASP A 1 239 ? 21.94356  -9.28102  -34.78832 1.000 14.71939 ? 320 ASP A OD2 1 
ATOM   2524 N N   . GLU A 1 240 ? 22.07516  -8.92350  -29.97907 1.000 10.52841 ? 321 GLU A N   1 
ATOM   2525 C CA  . GLU A 1 240 ? 22.61499  -9.69546  -28.86353 1.000 10.07794 ? 321 GLU A CA  1 
ATOM   2526 C C   . GLU A 1 240 ? 23.54898  -10.80237 -29.32925 1.000 9.76036  ? 321 GLU A C   1 
ATOM   2527 O O   . GLU A 1 240 ? 24.52083  -11.09981 -28.63421 1.000 11.05138 ? 321 GLU A O   1 
ATOM   2528 C CB  . GLU A 1 240 ? 21.49777  -10.23990 -27.98075 1.000 10.28471 ? 321 GLU A CB  1 
ATOM   2529 C CG  . GLU A 1 240 ? 20.67585  -9.14359  -27.28835 1.000 9.90998  ? 321 GLU A CG  1 
ATOM   2530 C CD  . GLU A 1 240 ? 21.53351  -8.22890  -26.45334 1.000 9.49890  ? 321 GLU A CD  1 
ATOM   2531 O OE1 . GLU A 1 240 ? 22.06573  -8.66965  -25.42242 1.000 11.06387 ? 321 GLU A OE1 1 
ATOM   2532 O OE2 . GLU A 1 240 ? 21.71396  -7.04685  -26.82781 1.000 10.71541 ? 321 GLU A OE2 1 
ATOM   2533 N N   . ILE A 1 241 ? 23.27739  -11.42902 -30.48183 1.000 11.22575 ? 322 ILE A N   1 
ATOM   2534 C CA  . ILE A 1 241 ? 24.15875  -12.51219 -30.92870 1.000 11.33292 ? 322 ILE A CA  1 
ATOM   2535 C C   . ILE A 1 241 ? 25.55879  -11.98402 -31.23269 1.000 10.86377 ? 322 ILE A C   1 
ATOM   2536 O O   . ILE A 1 241 ? 26.56304  -12.62864 -30.91804 1.000 11.17279 ? 322 ILE A O   1 
ATOM   2537 C CB  . ILE A 1 241 ? 23.55340  -13.32843 -32.09245 1.000 12.05666 ? 322 ILE A CB  1 
ATOM   2538 C CG1 . ILE A 1 241 ? 24.35424  -14.61061 -32.30381 1.000 16.70252 ? 322 ILE A CG1 1 
ATOM   2539 C CG2 . ILE A 1 241 ? 23.57156  -12.55400 -33.39574 1.000 13.79468 ? 322 ILE A CG2 1 
ATOM   2540 C CD1 . ILE A 1 241 ? 24.43178  -15.46199 -31.09896 1.000 20.71407 ? 322 ILE A CD1 1 
ATOM   2541 N N   . HIS A 1 242 ? 25.65803  -10.78246 -31.80755 1.000 11.14032 ? 323 HIS A N   1 
ATOM   2542 C CA  . HIS A 1 242 ? 26.98474  -10.21242 -32.03802 1.000 11.43429 ? 323 HIS A CA  1 
ATOM   2543 C C   . HIS A 1 242 ? 27.69540  -9.94754  -30.71753 1.000 10.28273 ? 323 HIS A C   1 
ATOM   2544 O O   . HIS A 1 242 ? 28.88637  -10.23082 -30.56663 1.000 11.32739 ? 323 HIS A O   1 
ATOM   2545 C CB  . HIS A 1 242 ? 26.89022  -8.90143  -32.82012 1.000 12.95978 ? 323 HIS A CB  1 
ATOM   2546 C CG  . HIS A 1 242 ? 26.78251  -9.06083  -34.30313 1.000 14.23881 ? 323 HIS A CG  1 
ATOM   2547 N ND1 . HIS A 1 242 ? 25.59833  -9.36790  -34.93525 1.000 14.75890 ? 323 HIS A ND1 1 
ATOM   2548 C CD2 . HIS A 1 242 ? 27.70164  -8.89833  -35.28523 1.000 18.51406 ? 323 HIS A CD2 1 
ATOM   2549 C CE1 . HIS A 1 242 ? 25.79674  -9.41950  -36.24174 1.000 18.48000 ? 323 HIS A CE1 1 
ATOM   2550 N NE2 . HIS A 1 242 ? 27.06413  -9.13539  -36.48005 1.000 18.47074 ? 323 HIS A NE2 1 
ATOM   2551 N N   . TYR A 1 243 ? 26.98148  -9.36174  -29.75163 1.000 10.31670 ? 324 TYR A N   1 
ATOM   2552 C CA  . TYR A 1 243 ? 27.57106  -9.08934  -28.44327 1.000 10.82481 ? 324 TYR A CA  1 
ATOM   2553 C C   . TYR A 1 243 ? 28.09568  -10.37188 -27.80276 1.000 9.82127  ? 324 TYR A C   1 
ATOM   2554 O O   . TYR A 1 243 ? 29.24365  -10.43604 -27.35092 1.000 10.16410 ? 324 TYR A O   1 
ATOM   2555 C CB  . TYR A 1 243 ? 26.50472  -8.40094  -27.57391 1.000 10.74592 ? 324 TYR A CB  1 
ATOM   2556 C CG  . TYR A 1 243 ? 26.77727  -8.28969  -26.08638 1.000 9.87113  ? 324 TYR A CG  1 
ATOM   2557 C CD1 . TYR A 1 243 ? 28.05751  -8.10305  -25.59381 1.000 10.25091 ? 324 TYR A CD1 1 
ATOM   2558 C CD2 . TYR A 1 243 ? 25.72257  -8.32323  -25.17672 1.000 9.74821  ? 324 TYR A CD2 1 
ATOM   2559 C CE1 . TYR A 1 243 ? 28.28795  -7.98054  -24.24828 1.000 9.32664  ? 324 TYR A CE1 1 
ATOM   2560 C CE2 . TYR A 1 243 ? 25.93735  -8.19389  -23.81765 1.000 9.20818  ? 324 TYR A CE2 1 
ATOM   2561 C CZ  . TYR A 1 243 ? 27.22166  -8.02699  -23.35965 1.000 8.78673  ? 324 TYR A CZ  1 
ATOM   2562 O OH  . TYR A 1 243 ? 27.49486  -7.91980  -22.01751 1.000 9.68212  ? 324 TYR A OH  1 
ATOM   2563 N N   . ILE A 1 244 ? 27.24256  -11.39428 -27.74095 1.000 10.14071 ? 325 ILE A N   1 
ATOM   2564 C CA  . ILE A 1 244 ? 27.58037  -12.64758 -27.07970 1.000 9.95840  ? 325 ILE A CA  1 
ATOM   2565 C C   . ILE A 1 244 ? 28.72684  -13.34903 -27.79191 1.000 9.79911  ? 325 ILE A C   1 
ATOM   2566 O O   . ILE A 1 244 ? 29.66085  -13.84978 -27.15306 1.000 10.84244 ? 325 ILE A O   1 
ATOM   2567 C CB  . ILE A 1 244 ? 26.31749  -13.51235 -26.95911 1.000 10.45739 ? 325 ILE A CB  1 
ATOM   2568 C CG1 . ILE A 1 244 ? 25.36939  -12.85234 -25.94983 1.000 10.63356 ? 325 ILE A CG1 1 
ATOM   2569 C CG2 . ILE A 1 244 ? 26.66144  -14.93978 -26.55337 1.000 11.32138 ? 325 ILE A CG2 1 
ATOM   2570 C CD1 . ILE A 1 244 ? 23.97206  -13.41082 -25.97047 1.000 12.06026 ? 325 ILE A CD1 1 
ATOM   2571 N N   . ASN A 1 245 ? 28.69089  -13.36598 -29.12503 1.000 10.83194 ? 326 ASN A N   1 
ATOM   2572 C CA  . ASN A 1 245 ? 29.78001  -13.96877 -29.88508 1.000 11.75584 ? 326 ASN A CA  1 
ATOM   2573 C C   . ASN A 1 245 ? 31.09857  -13.28590 -29.59027 1.000 11.52670 ? 326 ASN A C   1 
ATOM   2574 O O   . ASN A 1 245 ? 32.15054  -13.93235 -29.61762 1.000 12.92324 ? 326 ASN A O   1 
ATOM   2575 C CB  . ASN A 1 245 ? 29.50282  -13.85267 -31.38090 1.000 13.10067 ? 326 ASN A CB  1 
ATOM   2576 C CG  . ASN A 1 245 ? 28.50898  -14.86148 -31.87131 1.000 15.14488 ? 326 ASN A CG  1 
ATOM   2577 O OD1 . ASN A 1 245 ? 28.18670  -15.81360 -31.16933 1.000 16.20340 ? 326 ASN A OD1 1 
ATOM   2578 N ND2 . ASN A 1 245 ? 28.02260  -14.66856 -33.09111 1.000 15.65970 ? 326 ASN A ND2 1 
ATOM   2579 N N   . ALA A 1 246 ? 31.06587  -11.98172 -29.31576 1.000 11.82039 ? 327 ALA A N   1 
ATOM   2580 C CA  . ALA A 1 246 ? 32.30139  -11.25522 -29.05876 1.000 11.53501 ? 327 ALA A CA  1 
ATOM   2581 C C   . ALA A 1 246 ? 32.75431  -11.40865 -27.61431 1.000 10.93689 ? 327 ALA A C   1 
ATOM   2582 O O   . ALA A 1 246 ? 33.95695  -11.45760 -27.34697 1.000 13.58248 ? 327 ALA A O   1 
ATOM   2583 C CB  . ALA A 1 246 ? 32.13333  -9.78127  -29.43559 1.000 12.19744 ? 327 ALA A CB  1 
ATOM   2584 N N   . LEU A 1 247 ? 31.82102  -11.48701 -26.66415 1.000 11.06898 ? 328 LEU A N   1 
ATOM   2585 C CA  . LEU A 1 247 ? 32.21217  -11.52398 -25.25907 1.000 11.29389 ? 328 LEU A CA  1 
ATOM   2586 C C   . LEU A 1 247 ? 32.58836  -12.92884 -24.80276 1.000 10.16974 ? 328 LEU A C   1 
ATOM   2587 O O   . LEU A 1 247 ? 33.53079  -13.09841 -24.01729 1.000 11.66511 ? 328 LEU A O   1 
ATOM   2588 C CB  . LEU A 1 247 ? 31.07431  -10.98208 -24.38672 1.000 9.92841  ? 328 LEU A CB  1 
ATOM   2589 C CG  . LEU A 1 247 ? 31.32950  -10.96255 -22.88244 1.000 10.23347 ? 328 LEU A CG  1 
ATOM   2590 C CD1 . LEU A 1 247 ? 32.55204  -10.11726 -22.53538 1.000 14.47495 ? 328 LEU A CD1 1 
ATOM   2591 C CD2 . LEU A 1 247 ? 30.10451  -10.47657 -22.12956 1.000 11.20969 ? 328 LEU A CD2 1 
ATOM   2592 N N   . ALA A 1 248 ? 31.84526  -13.93393 -25.25469 1.000 11.13830 ? 329 ALA A N   1 
ATOM   2593 C CA  . ALA A 1 248 ? 32.06859  -15.30272 -24.78671 1.000 11.86279 ? 329 ALA A CA  1 
ATOM   2594 C C   . ALA A 1 248 ? 33.52214  -15.75554 -24.85976 1.000 12.25523 ? 329 ALA A C   1 
ATOM   2595 O O   . ALA A 1 248 ? 34.01566  -16.30309 -23.86194 1.000 13.72755 ? 329 ALA A O   1 
ATOM   2596 C CB  . ALA A 1 248 ? 31.12004  -16.29348 -25.47654 1.000 13.37435 ? 329 ALA A CB  1 
ATOM   2597 N N   . PRO A 1 249 ? 34.26062  -15.55896 -25.96128 1.000 12.19728 ? 330 PRO A N   1 
ATOM   2598 C CA  A PRO A 1 249 ? 35.65428  -16.03298 -25.98887 0.540 13.39095 ? 330 PRO A CA  1 
ATOM   2599 C CA  B PRO A 1 249 ? 35.65304  -16.03465 -25.98623 0.460 13.41287 ? 330 PRO A CA  1 
ATOM   2600 C C   . PRO A 1 249 ? 36.54418  -15.35027 -24.97401 1.000 14.34722 ? 330 PRO A C   1 
ATOM   2601 O O   . PRO A 1 249 ? 37.51402  -15.96265 -24.50842 1.000 15.27836 ? 330 PRO A O   1 
ATOM   2602 C CB  A PRO A 1 249 ? 36.10238  -15.74563 -27.42964 0.540 16.78658 ? 330 PRO A CB  1 
ATOM   2603 C CB  B PRO A 1 249 ? 36.09805  -15.75913 -27.43097 0.460 16.78674 ? 330 PRO A CB  1 
ATOM   2604 C CG  A PRO A 1 249 ? 34.84525  -15.63426 -28.20916 0.540 13.36077 ? 330 PRO A CG  1 
ATOM   2605 C CG  B PRO A 1 249 ? 35.15527  -14.72123 -27.92716 0.460 14.68943 ? 330 PRO A CG  1 
ATOM   2606 C CD  A PRO A 1 249 ? 33.83324  -15.05395 -27.27729 0.540 14.43151 ? 330 PRO A CD  1 
ATOM   2607 C CD  B PRO A 1 249 ? 33.84879  -15.04986 -27.27991 0.460 14.43256 ? 330 PRO A CD  1 
ATOM   2608 N N   . LEU A 1 250 ? 36.24705  -14.10149 -24.60845 1.000 13.46682 ? 331 LEU A N   1 
ATOM   2609 C CA  . LEU A 1 250 ? 37.05601  -13.44785 -23.58873 1.000 13.85694 ? 331 LEU A CA  1 
ATOM   2610 C C   . LEU A 1 250 ? 36.88942  -14.13615 -22.24032 1.000 14.40588 ? 331 LEU A C   1 
ATOM   2611 O O   . LEU A 1 250 ? 37.85908  -14.28951 -21.48500 1.000 17.86856 ? 331 LEU A O   1 
ATOM   2612 C CB  . LEU A 1 250 ? 36.67741  -11.97489 -23.49147 1.000 13.73256 ? 331 LEU A CB  1 
ATOM   2613 C CG  . LEU A 1 250 ? 36.70876  -11.21676 -24.81825 1.000 15.44974 ? 331 LEU A CG  1 
ATOM   2614 C CD1 . LEU A 1 250 ? 36.37494  -9.73783  -24.61395 1.000 16.59889 ? 331 LEU A CD1 1 
ATOM   2615 C CD2 . LEU A 1 250 ? 38.07322  -11.38051 -25.48540 1.000 19.52689 ? 331 LEU A CD2 1 
ATOM   2616 N N   . LEU A 1 251 ? 35.66961  -14.57639 -21.92513 1.000 13.72033 ? 332 LEU A N   1 
ATOM   2617 C CA  . LEU A 1 251 ? 35.44361  -15.32571 -20.69682 1.000 13.80016 ? 332 LEU A CA  1 
ATOM   2618 C C   . LEU A 1 251 ? 36.07511  -16.71304 -20.78639 1.000 14.74351 ? 332 LEU A C   1 
ATOM   2619 O O   . LEU A 1 251 ? 36.69960  -17.18734 -19.82322 1.000 15.51532 ? 332 LEU A O   1 
ATOM   2620 C CB  . LEU A 1 251 ? 33.93985  -15.43459 -20.44601 1.000 12.32120 ? 332 LEU A CB  1 
ATOM   2621 C CG  . LEU A 1 251 ? 33.14236  -14.12348 -20.41483 1.000 12.59755 ? 332 LEU A CG  1 
ATOM   2622 C CD1 . LEU A 1 251 ? 31.66061  -14.40191 -20.26660 1.000 12.91840 ? 332 LEU A CD1 1 
ATOM   2623 C CD2 . LEU A 1 251 ? 33.63717  -13.22699 -19.30375 1.000 14.08439 ? 332 LEU A CD2 1 
ATOM   2624 N N   A GLN A 1 252 ? 35.97636  -17.36810 -21.94678 0.786 15.10985 ? 333 GLN A N   1 
ATOM   2625 N N   B GLN A 1 252 ? 35.86964  -17.37736 -21.93039 0.214 15.15435 ? 333 GLN A N   1 
ATOM   2626 C CA  A GLN A 1 252 ? 36.60032  -18.68423 -22.10681 0.786 16.16958 ? 333 GLN A CA  1 
ATOM   2627 C CA  B GLN A 1 252 ? 36.34651  -18.72601 -22.20115 0.214 16.80738 ? 333 GLN A CA  1 
ATOM   2628 C C   A GLN A 1 252 ? 38.09722  -18.64190 -21.82398 0.786 17.44761 ? 333 GLN A C   1 
ATOM   2629 C C   B GLN A 1 252 ? 37.85029  -18.84405 -22.01918 0.214 18.13692 ? 333 GLN A C   1 
ATOM   2630 O O   A GLN A 1 252 ? 38.63867  -19.55868 -21.19028 0.786 14.20571 ? 333 GLN A O   1 
ATOM   2631 O O   B GLN A 1 252 ? 38.34794  -19.94119 -21.74506 0.214 18.90930 ? 333 GLN A O   1 
ATOM   2632 C CB  A GLN A 1 252 ? 36.34124  -19.22518 -23.51037 0.786 15.73563 ? 333 GLN A CB  1 
ATOM   2633 C CB  B GLN A 1 252 ? 35.97342  -19.05393 -23.65098 0.214 18.48851 ? 333 GLN A CB  1 
ATOM   2634 C CG  A GLN A 1 252 ? 34.87981  -19.51619 -23.79671 0.786 18.05481 ? 333 GLN A CG  1 
ATOM   2635 C CG  B GLN A 1 252 ? 34.63707  -19.76982 -23.82082 0.214 18.57738 ? 333 GLN A CG  1 
ATOM   2636 C CD  A GLN A 1 252 ? 34.62000  -19.98646 -25.22544 0.786 19.46234 ? 333 GLN A CD  1 
ATOM   2637 C CD  B GLN A 1 252 ? 34.22531  -19.90658 -25.28144 0.214 20.67948 ? 333 GLN A CD  1 
ATOM   2638 O OE1 A GLN A 1 252 ? 35.14691  -19.42981 -26.19102 0.786 20.80962 ? 333 GLN A OE1 1 
ATOM   2639 O OE1 B GLN A 1 252 ? 34.06950  -18.90840 -25.98956 0.214 21.60797 ? 333 GLN A OE1 1 
ATOM   2640 N NE2 A GLN A 1 252 ? 33.78549  -21.01240 -25.36136 0.786 24.59680 ? 333 GLN A NE2 1 
ATOM   2641 N NE2 B GLN A 1 252 ? 34.04268  -21.13992 -25.73556 0.214 22.49620 ? 333 GLN A NE2 1 
ATOM   2642 N N   A GLN A 1 253 ? 38.78307  -17.59141 -22.28921 0.786 16.98694 ? 334 GLN A N   1 
ATOM   2643 N N   B GLN A 1 253 ? 38.58148  -17.73821 -22.17459 0.214 16.70090 ? 334 GLN A N   1 
ATOM   2644 C CA  A GLN A 1 253 ? 40.22732  -17.49712 -22.08208 0.786 17.38405 ? 334 GLN A CA  1 
ATOM   2645 C CA  B GLN A 1 253 ? 40.01476  -17.71654 -21.91293 0.214 18.42145 ? 334 GLN A CA  1 
ATOM   2646 C C   A GLN A 1 253 ? 40.58938  -17.46057 -20.60390 0.786 19.38164 ? 334 GLN A C   1 
ATOM   2647 C C   B GLN A 1 253 ? 40.32902  -17.86617 -20.43022 0.214 19.15382 ? 334 GLN A C   1 
ATOM   2648 O O   A GLN A 1 253 ? 41.67984  -17.90129 -20.22492 0.786 18.01654 ? 334 GLN A O   1 
ATOM   2649 O O   B GLN A 1 253 ? 41.41035  -18.35329 -20.08343 0.214 18.40069 ? 334 GLN A O   1 
ATOM   2650 C CB  A GLN A 1 253 ? 40.80365  -16.26106 -22.77515 0.786 21.72523 ? 334 GLN A CB  1 
ATOM   2651 C CB  B GLN A 1 253 ? 40.59832  -16.40322 -22.44288 0.214 20.15183 ? 334 GLN A CB  1 
ATOM   2652 C CG  A GLN A 1 253 ? 40.42322  -16.06216 -24.23355 0.786 29.77719 ? 334 GLN A CG  1 
ATOM   2653 C CG  B GLN A 1 253 ? 42.11478  -16.27678 -22.37285 0.214 20.49221 ? 334 GLN A CG  1 
ATOM   2654 C CD  A GLN A 1 253 ? 40.38525  -17.35115 -25.03678 0.786 34.50317 ? 334 GLN A CD  1 
ATOM   2655 C CD  B GLN A 1 253 ? 42.60870  -14.94487 -22.91236 0.214 23.49362 ? 334 GLN A CD  1 
ATOM   2656 O OE1 A GLN A 1 253 ? 41.34126  -18.13358 -25.02880 0.786 34.14790 ? 334 GLN A OE1 1 
ATOM   2657 O OE1 B GLN A 1 253 ? 41.81954  -14.11422 -23.36439 0.214 26.15345 ? 334 GLN A OE1 1 
ATOM   2658 N NE2 A GLN A 1 253 ? 39.27672  -17.57342 -25.74887 0.786 22.24822 ? 334 GLN A NE2 1 
ATOM   2659 N NE2 B GLN A 1 253 ? 43.91990  -14.73457 -22.86513 0.214 23.33458 ? 334 GLN A NE2 1 
ATOM   2660 N N   A ALA A 1 254 ? 39.70642  -16.92458 -19.76027 0.786 17.69856 ? 335 ALA A N   1 
ATOM   2661 N N   B ALA A 1 254 ? 39.40880  -17.46943 -19.55206 0.214 17.93434 ? 335 ALA A N   1 
ATOM   2662 C CA  A ALA A 1 254 ? 39.92449  -16.88110 -18.31848 0.786 16.66890 ? 335 ALA A CA  1 
ATOM   2663 C CA  B ALA A 1 254 ? 39.66402  -17.48463 -18.11850 0.214 17.34649 ? 335 ALA A CA  1 
ATOM   2664 C C   A ALA A 1 254 ? 39.66638  -18.22428 -17.64005 0.786 16.25118 ? 335 ALA A C   1 
ATOM   2665 C C   B ALA A 1 254 ? 38.83352  -18.54755 -17.41296 0.214 19.64369 ? 335 ALA A C   1 
ATOM   2666 O O   A ALA A 1 254 ? 39.82412  -18.33162 -16.41416 0.786 19.20258 ? 335 ALA A O   1 
ATOM   2667 O O   B ALA A 1 254 ? 37.99630  -18.22084 -16.56625 0.214 20.69349 ? 335 ALA A O   1 
ATOM   2668 C CB  A ALA A 1 254 ? 39.05077  -15.78882 -17.69040 0.786 20.40778 ? 335 ALA A CB  1 
ATOM   2669 C CB  B ALA A 1 254 ? 39.38466  -16.10680 -17.51141 0.214 21.73969 ? 335 ALA A CB  1 
ATOM   2670 N N   A GLY A 1 255 ? 39.27479  -19.23988 -18.40051 0.786 15.52728 ? 336 GLY A N   1 
ATOM   2671 N N   B GLY A 1 255 ? 39.04392  -19.81351 -17.77156 0.214 16.38067 ? 336 GLY A N   1 
ATOM   2672 C CA  A GLY A 1 255 ? 38.93712  -20.53091 -17.85030 0.786 18.34814 ? 336 GLY A CA  1 
ATOM   2673 C CA  B GLY A 1 255 ? 38.46451  -20.94285 -17.06648 0.214 19.07079 ? 336 GLY A CA  1 
ATOM   2674 C C   A GLY A 1 255 ? 37.47841  -20.69533 -17.51131 0.786 13.76660 ? 336 GLY A C   1 
ATOM   2675 C C   B GLY A 1 255 ? 36.97576  -20.88764 -16.78939 0.214 15.58613 ? 336 GLY A C   1 
ATOM   2676 O O   A GLY A 1 255 ? 37.11116  -21.68897 -16.87106 0.786 15.62082 ? 336 GLY A O   1 
ATOM   2677 O O   B GLY A 1 255 ? 36.47162  -21.64189 -15.95366 0.214 20.34521 ? 336 GLY A O   1 
ATOM   2678 N N   A TRP A 1 256 ? 36.63481  -19.74850 -17.92062 0.786 15.06154 ? 337 TRP A N   1 
ATOM   2679 N N   B TRP A 1 256 ? 36.26599  -19.99619 -17.47616 0.214 14.74120 ? 337 TRP A N   1 
ATOM   2680 C CA  A TRP A 1 256 ? 35.20443  -19.79795 -17.66766 0.786 13.58257 ? 337 TRP A CA  1 
ATOM   2681 C CA  B TRP A 1 256 ? 34.82629  -19.80436 -17.32596 0.214 12.83986 ? 337 TRP A CA  1 
ATOM   2682 C C   A TRP A 1 256 ? 34.51488  -19.99373 -19.00772 0.786 13.10043 ? 337 TRP A C   1 
ATOM   2683 C C   B TRP A 1 256 ? 34.16722  -20.05447 -18.67374 0.214 12.68194 ? 337 TRP A C   1 
ATOM   2684 O O   A TRP A 1 256 ? 34.39349  -19.06230 -19.80200 0.786 15.17785 ? 337 TRP A O   1 
ATOM   2685 O O   B TRP A 1 256 ? 33.81611  -19.11772 -19.39396 0.214 15.93959 ? 337 TRP A O   1 
ATOM   2686 C CB  A TRP A 1 256 ? 34.76128  -18.49416 -17.04021 0.786 11.59230 ? 337 TRP A CB  1 
ATOM   2687 C CB  B TRP A 1 256 ? 34.53003  -18.40622 -16.81723 0.214 12.69894 ? 337 TRP A CB  1 
ATOM   2688 C CG  A TRP A 1 256 ? 33.33726  -18.46966 -16.62376 0.786 11.20301 ? 337 TRP A CG  1 
ATOM   2689 C CG  B TRP A 1 256 ? 33.11798  -18.20315 -16.35304 0.214 12.63483 ? 337 TRP A CG  1 
ATOM   2690 C CD1 A TRP A 1 256 ? 32.46500  -19.52319 -16.46407 0.786 12.14203 ? 337 TRP A CD1 1 
ATOM   2691 C CD1 B TRP A 1 256 ? 32.21820  -19.16436 -15.97688 0.214 11.31038 ? 337 TRP A CD1 1 
ATOM   2692 C CD2 A TRP A 1 256 ? 32.61200  -17.30413 -16.28535 0.786 10.66601 ? 337 TRP A CD2 1 
ATOM   2693 C CD2 B TRP A 1 256 ? 32.44447  -16.94896 -16.22162 0.214 13.00398 ? 337 TRP A CD2 1 
ATOM   2694 N NE1 A TRP A 1 256 ? 31.23979  -19.05778 -16.04859 0.786 14.21697 ? 337 TRP A NE1 1 
ATOM   2695 N NE1 B TRP A 1 256 ? 31.02600  -18.57677 -15.62305 0.214 9.30305  ? 337 TRP A NE1 1 
ATOM   2696 C CE2 A TRP A 1 256 ? 31.30726  -17.69656 -15.92882 0.786 11.76453 ? 337 TRP A CE2 1 
ATOM   2697 C CE2 B TRP A 1 256 ? 31.14249  -17.21812 -15.75935 0.214 12.95755 ? 337 TRP A CE2 1 
ATOM   2698 C CE3 A TRP A 1 256 ? 32.94348  -15.95115 -16.23850 0.786 11.93502 ? 337 TRP A CE3 1 
ATOM   2699 C CE3 B TRP A 1 256 ? 32.81867  -15.62110 -16.44869 0.214 14.40533 ? 337 TRP A CE3 1 
ATOM   2700 C CZ2 A TRP A 1 256 ? 30.33791  -16.77590 -15.53366 0.786 15.59459 ? 337 TRP A CZ2 1 
ATOM   2701 C CZ2 B TRP A 1 256 ? 30.21668  -16.20772 -15.51548 0.214 7.41289  ? 337 TRP A CZ2 1 
ATOM   2702 C CZ3 A TRP A 1 256 ? 31.98318  -15.04419 -15.84727 0.786 14.45929 ? 337 TRP A CZ3 1 
ATOM   2703 C CZ3 B TRP A 1 256 ? 31.89730  -14.62273 -16.21003 0.214 16.09563 ? 337 TRP A CZ3 1 
ATOM   2704 C CH2 A TRP A 1 256 ? 30.69630  -15.45642 -15.50898 0.786 16.82836 ? 337 TRP A CH2 1 
ATOM   2705 C CH2 B TRP A 1 256 ? 30.61122  -14.92087 -15.75365 0.214 14.33602 ? 337 TRP A CH2 1 
ATOM   2706 N N   A ASP A 1 257 ? 34.08009  -21.21582 -19.26954 0.786 15.47198 ? 338 ASP A N   1 
ATOM   2707 N N   B ASP A 1 257 ? 33.99777  -21.32869 -19.01599 0.214 14.39012 ? 338 ASP A N   1 
ATOM   2708 C CA  A ASP A 1 257 ? 33.34714  -21.50681 -20.49615 0.786 14.33885 ? 338 ASP A CA  1 
ATOM   2709 C CA  B ASP A 1 257 ? 33.21456  -21.67788 -20.19042 0.214 14.19122 ? 338 ASP A CA  1 
ATOM   2710 C C   A ASP A 1 257 ? 31.88839  -21.11615 -20.27750 0.786 13.17047 ? 338 ASP A C   1 
ATOM   2711 C C   B ASP A 1 257 ? 31.78872  -21.22573 -19.92377 0.214 14.11076 ? 338 ASP A C   1 
ATOM   2712 O O   A ASP A 1 257 ? 30.99636  -21.94943 -20.09521 0.786 16.05536 ? 338 ASP A O   1 
ATOM   2713 O O   B ASP A 1 257 ? 30.93901  -22.01758 -19.50305 0.214 14.97850 ? 338 ASP A O   1 
ATOM   2714 C CB  A ASP A 1 257 ? 33.52807  -22.96898 -20.88330 0.786 15.53791 ? 338 ASP A CB  1 
ATOM   2715 C CB  B ASP A 1 257 ? 33.27309  -23.18091 -20.46412 0.214 17.96755 ? 338 ASP A CB  1 
ATOM   2716 C CG  A ASP A 1 257 ? 33.03668  -23.26765 -22.27797 0.786 21.60331 ? 338 ASP A CG  1 
ATOM   2717 C CG  B ASP A 1 257 ? 32.43229  -23.59203 -21.65896 0.214 20.15183 ? 338 ASP A CG  1 
ATOM   2718 O OD1 A ASP A 1 257 ? 32.91846  -22.32314 -23.09065 0.786 21.26771 ? 338 ASP A OD1 1 
ATOM   2719 O OD1 B ASP A 1 257 ? 32.14280  -22.73034 -22.51541 0.214 23.45193 ? 338 ASP A OD1 1 
ATOM   2720 O OD2 A ASP A 1 257 ? 32.78147  -24.45967 -22.56228 0.786 30.63130 ? 338 ASP A OD2 1 
ATOM   2721 O OD2 B ASP A 1 257 ? 32.05795  -24.78076 -21.73747 0.214 26.87043 ? 338 ASP A OD2 1 
ATOM   2722 N N   A ALA A 1 258 ? 31.65188  -19.81151 -20.30528 0.786 12.98039 ? 339 ALA A N   1 
ATOM   2723 N N   B ALA A 1 258 ? 31.53573  -19.94093 -20.13556 0.214 12.27172 ? 339 ALA A N   1 
ATOM   2724 C CA  A ALA A 1 258 ? 30.37589  -19.25060 -19.89785 0.786 10.20822 ? 339 ALA A CA  1 
ATOM   2725 C CA  B ALA A 1 258 ? 30.26598  -19.34660 -19.76939 0.214 10.44922 ? 339 ALA A CA  1 
ATOM   2726 C C   A ALA A 1 258 ? 29.32577  -19.41366 -20.98442 0.786 9.93821  ? 339 ALA A C   1 
ATOM   2727 C C   B ALA A 1 258 ? 29.22509  -19.60159 -20.84724 0.214 9.34853  ? 339 ALA A C   1 
ATOM   2728 O O   A ALA A 1 258 ? 29.61763  -19.29491 -22.17851 0.786 11.29797 ? 339 ALA A O   1 
ATOM   2729 O O   B ALA A 1 258 ? 29.54160  -19.75162 -22.03224 0.214 9.10831  ? 339 ALA A O   1 
ATOM   2730 C CB  A ALA A 1 258 ? 30.57281  -17.76358 -19.61021 0.786 11.54338 ? 339 ALA A CB  1 
ATOM   2731 C CB  B ALA A 1 258 ? 30.43106  -17.84038 -19.56192 0.214 11.82996 ? 339 ALA A CB  1 
ATOM   2732 N N   A THR A 1 259 ? 28.08967  -19.64555 -20.56294 0.786 9.55692  ? 340 THR A N   1 
ATOM   2733 N N   B THR A 1 259 ? 27.96964  -19.65655 -20.41436 0.214 9.53457  ? 340 THR A N   1 
ATOM   2734 C CA  A THR A 1 259 ? 26.96160  -19.61836 -21.47019 0.786 9.63314  ? 340 THR A CA  1 
ATOM   2735 C CA  B THR A 1 259 ? 26.82830  -19.74133 -21.30630 0.214 9.93506  ? 340 THR A CA  1 
ATOM   2736 C C   A THR A 1 259 ? 26.00930  -18.49977 -21.06624 0.786 9.27671  ? 340 THR A C   1 
ATOM   2737 C C   B THR A 1 259 ? 25.84322  -18.64279 -20.93548 0.214 9.48176  ? 340 THR A C   1 
ATOM   2738 O O   A THR A 1 259 ? 26.20432  -17.81841 -20.05522 0.786 9.14630  ? 340 THR A O   1 
ATOM   2739 O O   B THR A 1 259 ? 25.85427  -18.12306 -19.81825 0.214 9.99703  ? 340 THR A O   1 
ATOM   2740 C CB  A THR A 1 259 ? 26.27363  -20.98203 -21.52756 0.786 9.07275  ? 340 THR A CB  1 
ATOM   2741 C CB  B THR A 1 259 ? 26.15551  -21.11256 -21.22330 0.214 10.92725 ? 340 THR A CB  1 
ATOM   2742 O OG1 A THR A 1 259 ? 25.94349  -21.41157 -20.19942 0.786 10.47289 ? 340 THR A OG1 1 
ATOM   2743 O OG1 B THR A 1 259 ? 25.85493  -21.41062 -19.85525 0.214 10.99246 ? 340 THR A OG1 1 
ATOM   2744 C CG2 A THR A 1 259 ? 27.19040  -21.99119 -22.18829 0.786 10.74443 ? 340 THR A CG2 1 
ATOM   2745 C CG2 B THR A 1 259 ? 27.06986  -22.19374 -21.78324 0.214 12.71298 ? 340 THR A CG2 1 
ATOM   2746 N N   . PHE A 1 260 ? 24.98113  -18.30176 -21.88674 1.000 9.15938  ? 341 PHE A N   1 
ATOM   2747 C CA  . PHE A 1 260 ? 24.17913  -17.09306 -21.82793 1.000 8.55792  ? 341 PHE A CA  1 
ATOM   2748 C C   . PHE A 1 260 ? 22.69239  -17.40404 -21.93192 1.000 8.91388  ? 341 PHE A C   1 
ATOM   2749 O O   . PHE A 1 260 ? 22.27901  -18.39641 -22.53514 1.000 9.44992  ? 341 PHE A O   1 
ATOM   2750 C CB  . PHE A 1 260 ? 24.54762  -16.15637 -22.99775 1.000 10.33763 ? 341 PHE A CB  1 
ATOM   2751 C CG  . PHE A 1 260 ? 25.93019  -15.57125 -22.91539 1.000 9.94389  ? 341 PHE A CG  1 
ATOM   2752 C CD1 . PHE A 1 260 ? 27.04799  -16.35222 -23.12587 1.000 9.73893  ? 341 PHE A CD1 1 
ATOM   2753 C CD2 . PHE A 1 260 ? 26.09410  -14.23042 -22.64729 1.000 10.43891 ? 341 PHE A CD2 1 
ATOM   2754 C CE1 . PHE A 1 260 ? 28.31828  -15.81278 -23.05597 1.000 12.25043 ? 341 PHE A CE1 1 
ATOM   2755 C CE2 . PHE A 1 260 ? 27.35846  -13.67101 -22.57883 1.000 10.84798 ? 341 PHE A CE2 1 
ATOM   2756 C CZ  . PHE A 1 260 ? 28.47336  -14.46732 -22.78478 1.000 11.65561 ? 341 PHE A CZ  1 
ATOM   2757 N N   . ILE A 1 261 ? 21.88767  -16.51267 -21.36321 1.000 8.83422  ? 342 ILE A N   1 
ATOM   2758 C CA  . ILE A 1 261 ? 20.46585  -16.46458 -21.65952 1.000 8.95514  ? 342 ILE A CA  1 
ATOM   2759 C C   . ILE A 1 261 ? 20.14050  -15.04945 -22.11328 1.000 8.88098  ? 342 ILE A C   1 
ATOM   2760 O O   . ILE A 1 261 ? 20.79804  -14.08376 -21.70881 1.000 9.12103  ? 342 ILE A O   1 
ATOM   2761 C CB  . ILE A 1 261 ? 19.58493  -16.92054 -20.47123 1.000 9.43000  ? 342 ILE A CB  1 
ATOM   2762 C CG1 . ILE A 1 261 ? 19.73838  -15.98872 -19.26417 1.000 9.53050  ? 342 ILE A CG1 1 
ATOM   2763 C CG2 . ILE A 1 261 ? 19.92581  -18.35757 -20.11355 1.000 9.50374  ? 342 ILE A CG2 1 
ATOM   2764 C CD1 . ILE A 1 261 ? 18.87541  -16.37811 -18.07812 1.000 11.35782 ? 342 ILE A CD1 1 
ATOM   2765 N N   . VAL A 1 262 ? 19.13093  -14.92759 -22.97901 1.000 8.25462  ? 343 VAL A N   1 
ATOM   2766 C CA  . VAL A 1 262 ? 18.79199  -13.65581 -23.61466 1.000 8.85109  ? 343 VAL A CA  1 
ATOM   2767 C C   . VAL A 1 262 ? 17.30155  -13.39474 -23.46687 1.000 8.81108  ? 343 VAL A C   1 
ATOM   2768 O O   . VAL A 1 262 ? 16.48152  -14.19027 -23.94317 1.000 9.36065  ? 343 VAL A O   1 
ATOM   2769 C CB  . VAL A 1 262 ? 19.18891  -13.62735 -25.09795 1.000 8.80629  ? 343 VAL A CB  1 
ATOM   2770 C CG1 . VAL A 1 262 ? 18.88810  -12.28182 -25.72015 1.000 10.52094 ? 343 VAL A CG1 1 
ATOM   2771 C CG2 . VAL A 1 262 ? 20.64407  -13.94216 -25.26185 1.000 11.78973 ? 343 VAL A CG2 1 
ATOM   2772 N N   . ASP A 1 263 ? 16.95930  -12.27889 -22.83086 1.000 8.88729  ? 344 ASP A N   1 
ATOM   2773 C CA  . ASP A 1 263 ? 15.56633  -11.85133 -22.75051 1.000 9.25697  ? 344 ASP A CA  1 
ATOM   2774 C C   . ASP A 1 263 ? 15.09508  -11.42717 -24.14046 1.000 9.06287  ? 344 ASP A C   1 
ATOM   2775 O O   . ASP A 1 263 ? 15.77561  -10.65374 -24.82530 1.000 9.46002  ? 344 ASP A O   1 
ATOM   2776 C CB  . ASP A 1 263 ? 15.47903  -10.66464 -21.78110 1.000 9.05197  ? 344 ASP A CB  1 
ATOM   2777 C CG  . ASP A 1 263 ? 14.07171  -10.39622 -21.23179 1.000 8.56801  ? 344 ASP A CG  1 
ATOM   2778 O OD1 . ASP A 1 263 ? 13.07672  -10.98200 -21.73113 1.000 9.67826  ? 344 ASP A OD1 1 
ATOM   2779 O OD2 . ASP A 1 263 ? 13.97862  -9.58156  -20.28935 1.000 9.81457  ? 344 ASP A OD2 1 
ATOM   2780 N N   . GLN A 1 264 ? 13.94867  -11.96306 -24.58086 1.000 9.48017  ? 345 GLN A N   1 
ATOM   2781 C CA  . GLN A 1 264 ? 13.28674  -11.52161 -25.80856 1.000 10.79635 ? 345 GLN A CA  1 
ATOM   2782 C C   . GLN A 1 264 ? 11.82653  -11.15973 -25.56157 1.000 8.88982  ? 345 GLN A C   1 
ATOM   2783 O O   . GLN A 1 264 ? 11.05839  -10.99385 -26.52577 1.000 10.62271 ? 345 GLN A O   1 
ATOM   2784 C CB  . GLN A 1 264 ? 13.40044  -12.56092 -26.93089 1.000 9.75523  ? 345 GLN A CB  1 
ATOM   2785 C CG  . GLN A 1 264 ? 14.81529  -12.76077 -27.43794 1.000 10.34296 ? 345 GLN A CG  1 
ATOM   2786 C CD  . GLN A 1 264 ? 15.28610  -11.61613 -28.32686 1.000 9.98413  ? 345 GLN A CD  1 
ATOM   2787 O OE1 . GLN A 1 264 ? 14.97637  -11.57087 -29.52075 1.000 11.16707 ? 345 GLN A OE1 1 
ATOM   2788 N NE2 . GLN A 1 264 ? 16.01985  -10.67465 -27.74207 1.000 10.14997 ? 345 GLN A NE2 1 
ATOM   2789 N N   . GLY A 1 265 ? 11.43017  -11.01788 -24.29747 1.000 8.90029  ? 346 GLY A N   1 
ATOM   2790 C CA  . GLY A 1 265 ? 10.03186  -10.78939 -23.97406 1.000 9.95674  ? 346 GLY A CA  1 
ATOM   2791 C C   . GLY A 1 265 ? 9.42976   -9.53412  -24.55900 1.000 10.59926 ? 346 GLY A C   1 
ATOM   2792 O O   . GLY A 1 265 ? 8.20879   -9.47213  -24.71283 1.000 11.80741 ? 346 GLY A O   1 
ATOM   2793 N N   . ARG A 1 266 ? 10.24335  -8.52141  -24.86906 1.000 10.10198 ? 347 ARG A N   1 
ATOM   2794 C CA  . ARG A 1 266 ? 9.73871   -7.29066  -25.47385 1.000 9.81400  ? 347 ARG A CA  1 
ATOM   2795 C C   . ARG A 1 266 ? 10.52035  -6.93936  -26.73178 1.000 10.22655 ? 347 ARG A C   1 
ATOM   2796 O O   . ARG A 1 266 ? 10.71987  -5.75768  -27.03806 1.000 10.49812 ? 347 ARG A O   1 
ATOM   2797 C CB  . ARG A 1 266 ? 9.70248   -6.12933  -24.48116 1.000 11.49017 ? 347 ARG A CB  1 
ATOM   2798 C CG  . ARG A 1 266 ? 8.80117   -6.39600  -23.28226 1.000 10.85829 ? 347 ARG A CG  1 
ATOM   2799 C CD  . ARG A 1 266 ? 8.56613   -5.17497  -22.42778 1.000 11.43847 ? 347 ARG A CD  1 
ATOM   2800 N NE  . ARG A 1 266 ? 9.78672   -4.75605  -21.75963 1.000 11.02471 ? 347 ARG A NE  1 
ATOM   2801 C CZ  . ARG A 1 266 ? 9.88236   -3.66600  -21.01694 1.000 9.85964  ? 347 ARG A CZ  1 
ATOM   2802 N NH1 . ARG A 1 266 ? 8.82431   -2.92190  -20.74973 1.000 11.11250 ? 347 ARG A NH1 1 
ATOM   2803 N NH2 . ARG A 1 266 ? 11.06687  -3.30735  -20.53336 1.000 11.44177 ? 347 ARG A NH2 1 
ATOM   2804 N N   . SER A 1 267 ? 10.97916  -7.95832  -27.46514 1.000 9.79561  ? 348 SER A N   1 
ATOM   2805 C CA  . SER A 1 267 ? 11.84077  -7.76066  -28.62444 1.000 10.52051 ? 348 SER A CA  1 
ATOM   2806 C C   . SER A 1 267 ? 11.14196  -8.00813  -29.95395 1.000 10.63907 ? 348 SER A C   1 
ATOM   2807 O O   . SER A 1 267 ? 11.80728  -7.99671  -30.99351 1.000 11.19982 ? 348 SER A O   1 
ATOM   2808 C CB  . SER A 1 267 ? 13.10048  -8.62717  -28.52014 1.000 10.93319 ? 348 SER A CB  1 
ATOM   2809 O OG  . SER A 1 267 ? 13.93569  -8.16675  -27.47356 1.000 11.37195 ? 348 SER A OG  1 
ATOM   2810 N N   . GLY A 1 268 ? 9.82370   -8.21813  -29.95262 1.000 10.99263 ? 349 GLY A N   1 
ATOM   2811 C CA  . GLY A 1 268 ? 9.13305   -8.54947  -31.18990 1.000 11.83200 ? 349 GLY A CA  1 
ATOM   2812 C C   . GLY A 1 268 ? 9.16585   -7.45065  -32.23372 1.000 13.86651 ? 349 GLY A C   1 
ATOM   2813 O O   . GLY A 1 268 ? 9.07597   -7.73457  -33.43601 1.000 13.76414 ? 349 GLY A O   1 
ATOM   2814 N N   . VAL A 1 269 ? 9.28482   -6.19699  -31.80269 1.000 11.44581 ? 350 VAL A N   1 
ATOM   2815 C CA  . VAL A 1 269 ? 9.27817   -5.04701  -32.70200 1.000 11.86857 ? 350 VAL A CA  1 
ATOM   2816 C C   . VAL A 1 269 ? 10.60370  -4.30985  -32.55260 1.000 11.79259 ? 350 VAL A C   1 
ATOM   2817 O O   . VAL A 1 269 ? 10.93101  -3.82262  -31.46199 1.000 11.89205 ? 350 VAL A O   1 
ATOM   2818 C CB  . VAL A 1 269 ? 8.08378   -4.11281  -32.43123 1.000 11.43832 ? 350 VAL A CB  1 
ATOM   2819 C CG1 . VAL A 1 269 ? 8.05894   -3.01156  -33.45748 1.000 16.33890 ? 350 VAL A CG1 1 
ATOM   2820 C CG2 . VAL A 1 269 ? 6.76631   -4.88083  -32.45572 1.000 13.95431 ? 350 VAL A CG2 1 
ATOM   2821 N N   . GLN A 1 270 ? 11.35509  -4.23176  -33.64144 1.000 12.34367 ? 351 GLN A N   1 
ATOM   2822 C CA  . GLN A 1 270 ? 12.61958  -3.51454  -33.69864 1.000 11.97232 ? 351 GLN A CA  1 
ATOM   2823 C C   . GLN A 1 270 ? 12.39147  -2.09894  -34.22933 1.000 12.29732 ? 351 GLN A C   1 
ATOM   2824 O O   . GLN A 1 270 ? 11.29607  -1.75647  -34.68488 1.000 12.07170 ? 351 GLN A O   1 
ATOM   2825 C CB  . GLN A 1 270 ? 13.60912  -4.30596  -34.55340 1.000 12.35339 ? 351 GLN A CB  1 
ATOM   2826 C CG  . GLN A 1 270 ? 13.94638  -5.64564  -33.91189 1.000 12.44434 ? 351 GLN A CG  1 
ATOM   2827 C CD  . GLN A 1 270 ? 14.57404  -5.44395  -32.54829 1.000 11.24517 ? 351 GLN A CD  1 
ATOM   2828 O OE1 . GLN A 1 270 ? 15.57830  -4.74377  -32.43258 1.000 11.79847 ? 351 GLN A OE1 1 
ATOM   2829 N NE2 . GLN A 1 270 ? 13.99295  -6.04586  -31.51155 1.000 11.69261 ? 351 GLN A NE2 1 
ATOM   2830 N N   . ASN A 1 271 ? 13.42037  -1.25182  -34.12183 1.000 11.63580 ? 352 ASN A N   1 
ATOM   2831 C CA  . ASN A 1 271 ? 13.39134  0.07504   -34.74434 1.000 12.67022 ? 352 ASN A CA  1 
ATOM   2832 C C   . ASN A 1 271 ? 12.28549  0.95155   -34.15313 1.000 12.98975 ? 352 ASN A C   1 
ATOM   2833 O O   . ASN A 1 271 ? 11.56940  1.65694   -34.87597 1.000 14.79271 ? 352 ASN A O   1 
ATOM   2834 C CB  . ASN A 1 271 ? 13.26176  -0.01832  -36.27034 1.000 13.34916 ? 352 ASN A CB  1 
ATOM   2835 C CG  . ASN A 1 271 ? 14.45467  -0.67175  -36.92061 1.000 14.78430 ? 352 ASN A CG  1 
ATOM   2836 O OD1 . ASN A 1 271 ? 15.35551  -1.15949  -36.24406 1.000 13.92861 ? 352 ASN A OD1 1 
ATOM   2837 N ND2 . ASN A 1 271 ? 14.48521  -0.67344  -38.25294 1.000 17.38787 ? 352 ASN A ND2 1 
ATOM   2838 N N   . ILE A 1 272 ? 12.15564  0.93395   -32.82628 1.000 12.28183 ? 353 ILE A N   1 
ATOM   2839 C CA  . ILE A 1 272 ? 11.14707  1.71037   -32.11451 1.000 13.93383 ? 353 ILE A CA  1 
ATOM   2840 C C   . ILE A 1 272 ? 11.74446  2.73455   -31.16355 1.000 13.41534 ? 353 ILE A C   1 
ATOM   2841 O O   . ILE A 1 272 ? 11.00007  3.39155   -30.43205 1.000 15.91698 ? 353 ILE A O   1 
ATOM   2842 C CB  . ILE A 1 272 ? 10.12575  0.81241   -31.37929 1.000 14.69302 ? 353 ILE A CB  1 
ATOM   2843 C CG1 . ILE A 1 272 ? 10.82995  -0.21314  -30.47761 1.000 13.68666 ? 353 ILE A CG1 1 
ATOM   2844 C CG2 . ILE A 1 272 ? 9.20734   0.13949   -32.38499 1.000 16.11681 ? 353 ILE A CG2 1 
ATOM   2845 C CD1 . ILE A 1 272 ? 9.88013   -1.03771  -29.61778 1.000 16.90659 ? 353 ILE A CD1 1 
ATOM   2846 N N   . ARG A 1 273 ? 13.05758  2.90076   -31.14115 1.000 13.43438 ? 354 ARG A N   1 
ATOM   2847 C CA  . ARG A 1 273 ? 13.68017  3.81109   -30.19224 1.000 13.46321 ? 354 ARG A CA  1 
ATOM   2848 C C   . ARG A 1 273 ? 14.36273  4.96320   -30.90681 1.000 14.08218 ? 354 ARG A C   1 
ATOM   2849 O O   . ARG A 1 273 ? 14.90592  4.80827   -32.00565 1.000 14.50891 ? 354 ARG A O   1 
ATOM   2850 C CB  . ARG A 1 273 ? 14.71231  3.09335   -29.33048 1.000 13.02816 ? 354 ARG A CB  1 
ATOM   2851 C CG  . ARG A 1 273 ? 14.07466  2.25052   -28.25495 1.000 13.00518 ? 354 ARG A CG  1 
ATOM   2852 C CD  . ARG A 1 273 ? 15.09750  1.42196   -27.54216 1.000 14.46036 ? 354 ARG A CD  1 
ATOM   2853 N NE  . ARG A 1 273 ? 15.52790  0.28148   -28.33560 1.000 11.48837 ? 354 ARG A NE  1 
ATOM   2854 C CZ  . ARG A 1 273 ? 16.30269  -0.68055  -27.85295 1.000 12.35383 ? 354 ARG A CZ  1 
ATOM   2855 N NH1 . ARG A 1 273 ? 16.81482  -0.60246  -26.63048 1.000 14.81957 ? 354 ARG A NH1 1 
ATOM   2856 N NH2 . ARG A 1 273 ? 16.55497  -1.75045  -28.59802 1.000 12.98139 ? 354 ARG A NH2 1 
ATOM   2857 N N   A GLN A 1 274 ? 14.35881  6.12861   -30.26393 0.618 14.77673 ? 355 GLN A N   1 
ATOM   2858 N N   B GLN A 1 274 ? 14.32939  6.12841   -30.25738 0.382 14.76401 ? 355 GLN A N   1 
ATOM   2859 C CA  A GLN A 1 274 ? 15.13981  7.22794   -30.81690 0.618 14.21220 ? 355 GLN A CA  1 
ATOM   2860 C CA  B GLN A 1 274 ? 15.09616  7.27324   -30.73585 0.382 14.27654 ? 355 GLN A CA  1 
ATOM   2861 C C   A GLN A 1 274 ? 16.61852  7.07826   -30.48071 0.618 15.88241 ? 355 GLN A C   1 
ATOM   2862 C C   B GLN A 1 274 ? 16.58238  7.07008   -30.46964 0.382 15.87719 ? 355 GLN A C   1 
ATOM   2863 O O   A GLN A 1 274 ? 17.47540  7.22524   -31.35895 0.618 15.97340 ? 355 GLN A O   1 
ATOM   2864 O O   B GLN A 1 274 ? 17.40713  7.15830   -31.38667 0.382 15.92017 ? 355 GLN A O   1 
ATOM   2865 C CB  A GLN A 1 274 ? 14.60966  8.57918   -30.34709 0.618 15.64303 ? 355 GLN A CB  1 
ATOM   2866 C CB  B GLN A 1 274 ? 14.59127  8.54824   -30.05475 0.382 16.30898 ? 355 GLN A CB  1 
ATOM   2867 C CG  A GLN A 1 274 ? 15.31158  9.77530   -31.00306 0.618 23.15362 ? 355 GLN A CG  1 
ATOM   2868 C CG  B GLN A 1 274 ? 15.49978  9.78614   -30.15005 0.382 20.48774 ? 355 GLN A CG  1 
ATOM   2869 C CD  A GLN A 1 274 ? 15.09636  9.84763   -32.51200 0.618 24.66570 ? 355 GLN A CD  1 
ATOM   2870 C CD  B GLN A 1 274 ? 16.07472  10.03129  -31.53239 0.382 22.28452 ? 355 GLN A CD  1 
ATOM   2871 O OE1 A GLN A 1 274 ? 14.00656  10.17985  -32.97510 0.618 29.22467 ? 355 GLN A OE1 1 
ATOM   2872 O OE1 B GLN A 1 274 ? 17.26620  10.29913  -31.67662 0.382 19.14077 ? 355 GLN A OE1 1 
ATOM   2873 N NE2 A GLN A 1 274 ? 16.14930  9.56811   -33.28256 0.618 22.88132 ? 355 GLN A NE2 1 
ATOM   2874 N NE2 B GLN A 1 274 ? 15.22365  9.97581   -32.55205 0.382 24.35570 ? 355 GLN A NE2 1 
ATOM   2875 N N   . GLN A 1 275 ? 16.94130  6.79589   -29.21794 1.000 13.73968 ? 356 GLN A N   1 
ATOM   2876 C CA  . GLN A 1 275 ? 18.30938  6.51143   -28.82481 1.000 13.62305 ? 356 GLN A CA  1 
ATOM   2877 C C   . GLN A 1 275 ? 18.39295  5.14916   -28.16097 1.000 11.36030 ? 356 GLN A C   1 
ATOM   2878 O O   . GLN A 1 275 ? 17.44399  4.69598   -27.51467 1.000 12.39037 ? 356 GLN A O   1 
ATOM   2879 C CB  . GLN A 1 275 ? 18.89960  7.58268   -27.91178 1.000 14.54361 ? 356 GLN A CB  1 
ATOM   2880 C CG  . GLN A 1 275 ? 18.68521  8.98788   -28.41320 1.000 16.40654 ? 356 GLN A CG  1 
ATOM   2881 C CD  . GLN A 1 275 ? 19.72287  9.90516   -27.85476 1.000 20.75481 ? 356 GLN A CD  1 
ATOM   2882 O OE1 . GLN A 1 275 ? 20.65797  10.30783  -28.55534 1.000 22.43757 ? 356 GLN A OE1 1 
ATOM   2883 N NE2 . GLN A 1 275 ? 19.59981  10.20951  -26.57976 1.000 19.88732 ? 356 GLN A NE2 1 
ATOM   2884 N N   . TRP A 1 276 ? 19.54936  4.51181   -28.32041 1.000 12.06389 ? 357 TRP A N   1 
ATOM   2885 C CA  . TRP A 1 276 ? 19.70103  3.15581   -27.80946 1.000 11.00668 ? 357 TRP A CA  1 
ATOM   2886 C C   . TRP A 1 276 ? 19.50449  3.08809   -26.30618 1.000 12.52671 ? 357 TRP A C   1 
ATOM   2887 O O   . TRP A 1 276 ? 18.99557  2.08070   -25.80368 1.000 12.85981 ? 357 TRP A O   1 
ATOM   2888 C CB  . TRP A 1 276 ? 21.07054  2.60820   -28.18333 1.000 11.40912 ? 357 TRP A CB  1 
ATOM   2889 C CG  . TRP A 1 276 ? 21.10898  1.11429   -28.36379 1.000 11.14096 ? 357 TRP A CG  1 
ATOM   2890 C CD1 . TRP A 1 276 ? 20.16477  0.18907   -27.97738 1.000 11.09976 ? 357 TRP A CD1 1 
ATOM   2891 C CD2 . TRP A 1 276 ? 22.16383  0.37340   -28.97807 1.000 10.58414 ? 357 TRP A CD2 1 
ATOM   2892 N NE1 . TRP A 1 276 ? 20.56933  -1.07781  -28.33648 1.000 10.91000 ? 357 TRP A NE1 1 
ATOM   2893 C CE2 . TRP A 1 276 ? 21.79491  -0.98915  -28.94969 1.000 10.03239 ? 357 TRP A CE2 1 
ATOM   2894 C CE3 . TRP A 1 276 ? 23.38788  0.73525   -29.55482 1.000 11.09292 ? 357 TRP A CE3 1 
ATOM   2895 C CZ2 . TRP A 1 276 ? 22.60448  -1.98412  -29.48788 1.000 12.40036 ? 357 TRP A CZ2 1 
ATOM   2896 C CZ3 . TRP A 1 276 ? 24.19460  -0.25218  -30.08124 1.000 11.99304 ? 357 TRP A CZ3 1 
ATOM   2897 C CH2 . TRP A 1 276 ? 23.80256  -1.60005  -30.04402 1.000 10.90321 ? 357 TRP A CH2 1 
ATOM   2898 N N   . GLY A 1 277 ? 19.89447  4.12634   -25.57890 1.000 13.22172 ? 358 GLY A N   1 
ATOM   2899 C CA  . GLY A 1 277 ? 19.77359  4.11809   -24.13852 1.000 15.07085 ? 358 GLY A CA  1 
ATOM   2900 C C   . GLY A 1 277 ? 18.37806  4.29535   -23.59552 1.000 13.00319 ? 358 GLY A C   1 
ATOM   2901 O O   . GLY A 1 277 ? 18.19917  4.23918   -22.37726 1.000 15.55451 ? 358 GLY A O   1 
ATOM   2902 N N   . ASP A 1 278 ? 17.37792  4.50929   -24.44493 1.000 11.93666 ? 359 ASP A N   1 
ATOM   2903 C CA  . ASP A 1 278 ? 16.00844  4.71924   -23.98586 1.000 12.09749 ? 359 ASP A CA  1 
ATOM   2904 C C   . ASP A 1 278 ? 15.42693  3.36889   -23.58990 1.000 12.03796 ? 359 ASP A C   1 
ATOM   2905 O O   . ASP A 1 278 ? 15.23044  2.50406   -24.44596 1.000 15.60234 ? 359 ASP A O   1 
ATOM   2906 C CB  . ASP A 1 278 ? 15.15440  5.32172   -25.09936 1.000 13.43677 ? 359 ASP A CB  1 
ATOM   2907 C CG  . ASP A 1 278 ? 15.67223  6.65863   -25.59972 1.000 15.92853 ? 359 ASP A CG  1 
ATOM   2908 O OD1 . ASP A 1 278 ? 16.55833  7.26021   -24.96163 1.000 13.53048 ? 359 ASP A OD1 1 
ATOM   2909 O OD2 . ASP A 1 278 ? 15.18376  7.09480   -26.66366 1.000 14.60314 ? 359 ASP A OD2 1 
ATOM   2910 N N   . TRP A 1 279 ? 15.12969  3.18219   -22.30705 1.000 11.89109 ? 360 TRP A N   1 
ATOM   2911 C CA  . TRP A 1 279 ? 14.75986  1.86855   -21.79772 1.000 11.49468 ? 360 TRP A CA  1 
ATOM   2912 C C   . TRP A 1 279 ? 13.35953  1.78867   -21.20847 1.000 11.47381 ? 360 TRP A C   1 
ATOM   2913 O O   . TRP A 1 279 ? 12.90600  0.67382   -20.91463 1.000 12.17269 ? 360 TRP A O   1 
ATOM   2914 C CB  . TRP A 1 279 ? 15.75761  1.39808   -20.72000 1.000 14.72906 ? 360 TRP A CB  1 
ATOM   2915 C CG  . TRP A 1 279 ? 15.95529  2.41084   -19.60599 1.000 14.88686 ? 360 TRP A CG  1 
ATOM   2916 C CD1 . TRP A 1 279 ? 16.93581  3.35598   -19.53247 1.000 18.96704 ? 360 TRP A CD1 1 
ATOM   2917 C CD2 . TRP A 1 279 ? 15.14003  2.59161   -18.43488 1.000 14.20810 ? 360 TRP A CD2 1 
ATOM   2918 N NE1 . TRP A 1 279 ? 16.78938  4.10762   -18.38981 1.000 18.37126 ? 360 TRP A NE1 1 
ATOM   2919 C CE2 . TRP A 1 279 ? 15.69094  3.66366   -17.70219 1.000 16.53058 ? 360 TRP A CE2 1 
ATOM   2920 C CE3 . TRP A 1 279 ? 14.00046  1.95504   -17.93443 1.000 13.58339 ? 360 TRP A CE3 1 
ATOM   2921 C CZ2 . TRP A 1 279 ? 15.14565  4.10447   -16.49937 1.000 18.07279 ? 360 TRP A CZ2 1 
ATOM   2922 C CZ3 . TRP A 1 279 ? 13.45546  2.40384   -16.73994 1.000 15.87642 ? 360 TRP A CZ3 1 
ATOM   2923 C CH2 . TRP A 1 279 ? 14.02648  3.46577   -16.03867 1.000 18.55441 ? 360 TRP A CH2 1 
ATOM   2924 N N   . CYS A 1 280 ? 12.67484  2.91095   -20.98230 1.000 12.07968 ? 361 CYS A N   1 
ATOM   2925 C CA  . CYS A 1 280 ? 11.46986  2.90919   -20.15767 1.000 11.58996 ? 361 CYS A CA  1 
ATOM   2926 C C   . CYS A 1 280 ? 10.20678  2.83277   -21.00671 1.000 11.91214 ? 361 CYS A C   1 
ATOM   2927 O O   . CYS A 1 280 ? 9.91863   3.75424   -21.77421 1.000 12.63315 ? 361 CYS A O   1 
ATOM   2928 C CB  . CYS A 1 280 ? 11.42758  4.14164   -19.25881 1.000 12.72530 ? 361 CYS A CB  1 
ATOM   2929 S SG  . CYS A 1 280 ? 10.07444  4.04420   -18.08327 1.000 14.04723 ? 361 CYS A SG  1 
ATOM   2930 N N   . ASN A 1 281 ? 9.45596   1.74431   -20.84917 1.000 11.59432 ? 362 ASN A N   1 
ATOM   2931 C CA  . ASN A 1 281 ? 8.12258   1.59741   -21.43863 1.000 11.79534 ? 362 ASN A CA  1 
ATOM   2932 C C   . ASN A 1 281 ? 8.09769   1.97121   -22.91830 1.000 11.52263 ? 362 ASN A C   1 
ATOM   2933 O O   . ASN A 1 281 ? 7.24073   2.74419   -23.36520 1.000 12.14378 ? 362 ASN A O   1 
ATOM   2934 C CB  . ASN A 1 281 ? 7.07108   2.42480   -20.68161 1.000 11.99581 ? 362 ASN A CB  1 
ATOM   2935 C CG  . ASN A 1 281 ? 6.97548   2.06308   -19.22272 1.000 12.98289 ? 362 ASN A CG  1 
ATOM   2936 O OD1 . ASN A 1 281 ? 7.00157   0.88985   -18.86299 1.000 12.51731 ? 362 ASN A OD1 1 
ATOM   2937 N ND2 . ASN A 1 281 ? 6.84531   3.06875   -18.36994 1.000 13.88122 ? 362 ASN A ND2 1 
ATOM   2938 N N   . ILE A 1 282 ? 9.03131   1.42206   -23.70053 1.000 11.95193 ? 363 ILE A N   1 
ATOM   2939 C CA  . ILE A 1 282 ? 9.17452   1.90696   -25.07099 1.000 13.13790 ? 363 ILE A CA  1 
ATOM   2940 C C   . ILE A 1 282 ? 7.91350   1.61525   -25.87289 1.000 12.37231 ? 363 ILE A C   1 
ATOM   2941 O O   . ILE A 1 282 ? 7.42608   0.48003   -25.91817 1.000 12.77959 ? 363 ILE A O   1 
ATOM   2942 C CB  . ILE A 1 282 ? 10.43561  1.34620   -25.73810 1.000 12.95880 ? 363 ILE A CB  1 
ATOM   2943 C CG1 . ILE A 1 282 ? 11.69590  1.83954   -25.01839 1.000 13.51042 ? 363 ILE A CG1 1 
ATOM   2944 C CG2 . ILE A 1 282 ? 10.46275  1.75590   -27.20550 1.000 14.74589 ? 363 ILE A CG2 1 
ATOM   2945 C CD1 . ILE A 1 282 ? 11.89551  3.34397   -25.03559 1.000 13.52441 ? 363 ILE A CD1 1 
ATOM   2946 N N   . LYS A 1 283 ? 7.38055   2.65285   -26.50992 1.000 12.85112 ? 364 LYS A N   1 
ATOM   2947 C CA  . LYS A 1 283 ? 6.08840   2.56479   -27.17423 1.000 12.83476 ? 364 LYS A CA  1 
ATOM   2948 C C   . LYS A 1 283 ? 6.15561   1.68181   -28.40920 1.000 12.95209 ? 364 LYS A C   1 
ATOM   2949 O O   . LYS A 1 283 ? 7.09736   1.76147   -29.20013 1.000 13.80275 ? 364 LYS A O   1 
ATOM   2950 C CB  . LYS A 1 283 ? 5.63877   3.96570   -27.58134 1.000 19.30844 ? 364 LYS A CB  1 
ATOM   2951 C CG  . LYS A 1 283 ? 4.15907   4.07003   -27.90006 1.000 23.05819 ? 364 LYS A CG  1 
ATOM   2952 C CD  . LYS A 1 283 ? 3.76715   5.47726   -28.35613 1.000 35.84104 ? 364 LYS A CD  1 
ATOM   2953 C CE  . LYS A 1 283 ? 4.71800   6.52962   -27.79899 1.000 31.16620 ? 364 LYS A CE  1 
ATOM   2954 N NZ  . LYS A 1 283 ? 4.80055   7.74103   -28.66584 1.000 49.09480 ? 364 LYS A NZ  1 
ATOM   2955 N N   . GLY A 1 284 ? 5.14227   0.83237   -28.57136 1.000 13.82943 ? 365 GLY A N   1 
ATOM   2956 C CA  . GLY A 1 284 ? 5.06080   -0.04500  -29.71425 1.000 15.06988 ? 365 GLY A CA  1 
ATOM   2957 C C   . GLY A 1 284 ? 5.78281   -1.36441  -29.56708 1.000 12.66846 ? 365 GLY A C   1 
ATOM   2958 O O   . GLY A 1 284 ? 5.83677   -2.12775  -30.53401 1.000 13.90422 ? 365 GLY A O   1 
ATOM   2959 N N   . ALA A 1 285 ? 6.35389   -1.65432  -28.40139 1.000 12.39738 ? 366 ALA A N   1 
ATOM   2960 C CA  . ALA A 1 285 ? 7.01698   -2.93530  -28.21685 1.000 11.99000 ? 366 ALA A CA  1 
ATOM   2961 C C   . ALA A 1 285 ? 6.01439   -4.07103  -28.37475 1.000 12.52654 ? 366 ALA A C   1 
ATOM   2962 O O   . ALA A 1 285 ? 4.82913   -3.93802  -28.04602 1.000 12.52789 ? 366 ALA A O   1 
ATOM   2963 C CB  . ALA A 1 285 ? 7.66995   -2.99565  -26.83681 1.000 11.99913 ? 366 ALA A CB  1 
ATOM   2964 N N   . GLY A 1 286 ? 6.49716   -5.19192  -28.89270 1.000 12.36115 ? 367 GLY A N   1 
ATOM   2965 C CA  . GLY A 1 286 ? 5.69269   -6.39568  -28.98577 1.000 11.41364 ? 367 GLY A CA  1 
ATOM   2966 C C   . GLY A 1 286 ? 6.39953   -7.56639  -28.33285 1.000 11.17700 ? 367 GLY A C   1 
ATOM   2967 O O   . GLY A 1 286 ? 7.62580   -7.59978  -28.23465 1.000 11.15903 ? 367 GLY A O   1 
ATOM   2968 N N   . PHE A 1 287 ? 5.60484   -8.52687  -27.85747 1.000 11.19719 ? 368 PHE A N   1 
ATOM   2969 C CA  . PHE A 1 287 ? 6.20095   -9.76025  -27.35253 1.000 10.93011 ? 368 PHE A CA  1 
ATOM   2970 C C   . PHE A 1 287 ? 7.06604   -10.37275 -28.44362 1.000 11.24936 ? 368 PHE A C   1 
ATOM   2971 O O   . PHE A 1 287 ? 6.68689   -10.39242 -29.61979 1.000 12.65565 ? 368 PHE A O   1 
ATOM   2972 C CB  . PHE A 1 287 ? 5.10770   -10.75474 -26.96948 1.000 11.90367 ? 368 PHE A CB  1 
ATOM   2973 C CG  . PHE A 1 287 ? 4.38488   -10.43410 -25.69639 1.000 11.54318 ? 368 PHE A CG  1 
ATOM   2974 C CD1 . PHE A 1 287 ? 5.06214   -10.24993 -24.50484 1.000 12.69997 ? 368 PHE A CD1 1 
ATOM   2975 C CD2 . PHE A 1 287 ? 2.99594   -10.34098 -25.68794 1.000 13.28545 ? 368 PHE A CD2 1 
ATOM   2976 C CE1 . PHE A 1 287 ? 4.36902   -9.98223  -23.32781 1.000 13.62722 ? 368 PHE A CE1 1 
ATOM   2977 C CE2 . PHE A 1 287 ? 2.30921   -10.07088 -24.52608 1.000 14.59969 ? 368 PHE A CE2 1 
ATOM   2978 C CZ  . PHE A 1 287 ? 2.98333   -9.89065  -23.34640 1.000 13.94776 ? 368 PHE A CZ  1 
ATOM   2979 N N   . GLY A 1 288 ? 8.24274   -10.86447 -28.06210 1.000 10.81661 ? 369 GLY A N   1 
ATOM   2980 C CA  . GLY A 1 288 ? 9.17405   -11.46271 -28.99148 1.000 10.97576 ? 369 GLY A CA  1 
ATOM   2981 C C   . GLY A 1 288 ? 9.18005   -12.97626 -28.94676 1.000 11.45709 ? 369 GLY A C   1 
ATOM   2982 O O   . GLY A 1 288 ? 8.22038   -13.62352 -28.50808 1.000 11.43640 ? 369 GLY A O   1 
ATOM   2983 N N   . THR A 1 289 ? 10.28897  -13.54708 -29.41834 1.000 11.41875 ? 370 THR A N   1 
ATOM   2984 C CA  . THR A 1 289 ? 10.42554  -14.99726 -29.50112 1.000 11.77536 ? 370 THR A CA  1 
ATOM   2985 C C   . THR A 1 289 ? 10.12348  -15.63391 -28.15369 1.000 10.42208 ? 370 THR A C   1 
ATOM   2986 O O   . THR A 1 289 ? 10.61789  -15.18410 -27.11349 1.000 10.55118 ? 370 THR A O   1 
ATOM   2987 C CB  . THR A 1 289 ? 11.86023  -15.32823 -29.91701 1.000 11.29274 ? 370 THR A CB  1 
ATOM   2988 O OG1 . THR A 1 289 ? 12.14314  -14.67197 -31.15939 1.000 12.96536 ? 370 THR A OG1 1 
ATOM   2989 C CG2 . THR A 1 289 ? 12.06354  -16.82796 -30.06530 1.000 13.17336 ? 370 THR A CG2 1 
ATOM   2990 N N   . ARG A 1 290 ? 9.30237   -16.68991 -28.17186 1.000 11.66468 ? 371 ARG A N   1 
ATOM   2991 C CA  A ARG A 1 290 ? 8.94273   -17.32772 -26.92045 0.507 11.68300 ? 371 ARG A CA  1 
ATOM   2992 C CA  B ARG A 1 290 ? 8.92773   -17.37553 -26.94184 0.493 11.71232 ? 371 ARG A CA  1 
ATOM   2993 C C   . ARG A 1 290 ? 10.14160  -18.09734 -26.36231 1.000 10.84446 ? 371 ARG A C   1 
ATOM   2994 O O   . ARG A 1 290 ? 11.02523  -18.52015 -27.10797 1.000 11.79075 ? 371 ARG A O   1 
ATOM   2995 C CB  A ARG A 1 290 ? 7.73665   -18.25264 -27.10088 0.507 11.55022 ? 371 ARG A CB  1 
ATOM   2996 C CB  B ARG A 1 290 ? 7.83832   -18.41528 -27.21810 0.493 12.21864 ? 371 ARG A CB  1 
ATOM   2997 C CG  A ARG A 1 290 ? 6.41156   -17.60973 -26.69884 0.507 15.48194 ? 371 ARG A CG  1 
ATOM   2998 C CG  B ARG A 1 290 ? 6.73098   -17.95526 -28.14262 0.493 14.06261 ? 371 ARG A CG  1 
ATOM   2999 C CD  A ARG A 1 290 ? 6.13274   -16.37209 -27.52297 0.507 18.59892 ? 371 ARG A CD  1 
ATOM   3000 C CD  B ARG A 1 290 ? 5.95961   -16.81867 -27.52363 0.493 20.15081 ? 371 ARG A CD  1 
ATOM   3001 N NE  A ARG A 1 290 ? 5.30009   -16.67418 -28.68234 0.507 21.84540 ? 371 ARG A NE  1 
ATOM   3002 N NE  B ARG A 1 290 ? 6.17881   -15.56108 -28.22951 0.493 16.26729 ? 371 ARG A NE  1 
ATOM   3003 C CZ  A ARG A 1 290 ? 5.11832   -15.84919 -29.70444 0.507 22.35024 ? 371 ARG A CZ  1 
ATOM   3004 C CZ  B ARG A 1 290 ? 5.48948   -15.16030 -29.28991 0.493 18.14473 ? 371 ARG A CZ  1 
ATOM   3005 N NH1 A ARG A 1 290 ? 5.68550   -14.65474 -29.73646 0.507 14.96637 ? 371 ARG A NH1 1 
ATOM   3006 N NH1 B ARG A 1 290 ? 4.54732   -15.91829 -29.82995 0.493 22.88411 ? 371 ARG A NH1 1 
ATOM   3007 N NH2 A ARG A 1 290 ? 4.35316   -16.23393 -30.72098 0.507 22.83118 ? 371 ARG A NH2 1 
ATOM   3008 N NH2 B ARG A 1 290 ? 5.74345   -13.96406 -29.81333 0.493 15.92453 ? 371 ARG A NH2 1 
ATOM   3009 N N   . PRO A 1 291 ? 10.20418  -18.26107 -25.04160 1.000 10.74226 ? 372 PRO A N   1 
ATOM   3010 C CA  . PRO A 1 291 ? 11.34611  -18.95937 -24.44296 1.000 10.34386 ? 372 PRO A CA  1 
ATOM   3011 C C   . PRO A 1 291 ? 11.57192  -20.32354 -25.07848 1.000 10.29990 ? 372 PRO A C   1 
ATOM   3012 O O   . PRO A 1 291 ? 10.62323  -21.06977 -25.35913 1.000 10.88581 ? 372 PRO A O   1 
ATOM   3013 C CB  . PRO A 1 291 ? 10.95035  -19.07543 -22.97208 1.000 11.70094 ? 372 PRO A CB  1 
ATOM   3014 C CG  . PRO A 1 291 ? 10.06542  -17.85729 -22.74478 1.000 11.36045 ? 372 PRO A CG  1 
ATOM   3015 C CD  . PRO A 1 291 ? 9.29203   -17.71620 -24.01853 1.000 10.78116 ? 372 PRO A CD  1 
ATOM   3016 N N   . THR A 1 292 ? 12.84277  -20.64278 -25.31118 1.000 10.23783 ? 373 THR A N   1 
ATOM   3017 C CA  . THR A 1 292 ? 13.21699  -21.88538 -25.96585 1.000 11.82870 ? 373 THR A CA  1 
ATOM   3018 C C   . THR A 1 292 ? 14.71453  -22.10257 -25.81466 1.000 10.19901 ? 373 THR A C   1 
ATOM   3019 O O   . THR A 1 292 ? 15.48931  -21.14590 -25.80917 1.000 10.40874 ? 373 THR A O   1 
ATOM   3020 C CB  . THR A 1 292 ? 12.84651  -21.85922 -27.45565 1.000 11.74919 ? 373 THR A CB  1 
ATOM   3021 O OG1 . THR A 1 292 ? 13.30473  -23.07053 -28.06221 1.000 13.05985 ? 373 THR A OG1 1 
ATOM   3022 C CG2 . THR A 1 292 ? 13.49737  -20.69640 -28.17670 1.000 12.47692 ? 373 THR A CG2 1 
ATOM   3023 N N   . THR A 1 293 ? 15.11049  -23.36694 -25.72193 1.000 10.62640 ? 374 THR A N   1 
ATOM   3024 C CA  . THR A 1 293 ? 16.52069  -23.71863 -25.81120 1.000 11.75408 ? 374 THR A CA  1 
ATOM   3025 C C   . THR A 1 293 ? 17.01141  -23.83713 -27.24958 1.000 11.65011 ? 374 THR A C   1 
ATOM   3026 O O   . THR A 1 293 ? 18.20147  -24.08112 -27.47204 1.000 12.90686 ? 374 THR A O   1 
ATOM   3027 C CB  . THR A 1 293 ? 16.82628  -24.99162 -25.02917 1.000 11.74274 ? 374 THR A CB  1 
ATOM   3028 O OG1 . THR A 1 293 ? 16.12007  -26.09153 -25.61463 1.000 14.55677 ? 374 THR A OG1 1 
ATOM   3029 C CG2 . THR A 1 293 ? 16.42976  -24.84316 -23.56991 1.000 12.80364 ? 374 THR A CG2 1 
ATOM   3030 N N   . ASN A 1 294 ? 16.13518  -23.65468 -28.23446 1.000 12.88221 ? 375 ASN A N   1 
ATOM   3031 C CA  A ASN A 1 294 ? 16.53873  -23.62585 -29.63951 0.647 13.47798 ? 375 ASN A CA  1 
ATOM   3032 C CA  B ASN A 1 294 ? 16.53905  -23.62541 -29.63979 0.353 13.53760 ? 375 ASN A CA  1 
ATOM   3033 C C   . ASN A 1 294 ? 16.97677  -22.19925 -29.95180 1.000 13.71937 ? 375 ASN A C   1 
ATOM   3034 O O   . ASN A 1 294 ? 16.22454  -21.37931 -30.48662 1.000 15.67943 ? 375 ASN A O   1 
ATOM   3035 C CB  A ASN A 1 294 ? 15.38035  -24.07060 -30.52337 0.647 16.88653 ? 375 ASN A CB  1 
ATOM   3036 C CB  B ASN A 1 294 ? 15.38358  -24.05884 -30.53058 0.353 16.86348 ? 375 ASN A CB  1 
ATOM   3037 C CG  A ASN A 1 294 ? 15.70933  -24.00180 -32.00337 0.647 19.76621 ? 375 ASN A CG  1 
ATOM   3038 C CG  B ASN A 1 294 ? 14.98168  -25.50100 -30.30475 0.353 16.72531 ? 375 ASN A CG  1 
ATOM   3039 O OD1 A ASN A 1 294 ? 16.87124  -24.03706 -32.39544 0.647 21.05517 ? 375 ASN A OD1 1 
ATOM   3040 O OD1 B ASN A 1 294 ? 15.77642  -26.31422 -29.83689 0.353 19.66024 ? 375 ASN A OD1 1 
ATOM   3041 N ND2 A ASN A 1 294 ? 14.67756  -23.90156 -32.83311 0.647 25.00263 ? 375 ASN A ND2 1 
ATOM   3042 N ND2 B ASN A 1 294 ? 13.73788  -25.82604 -30.63784 0.353 18.02544 ? 375 ASN A ND2 1 
ATOM   3043 N N   . THR A 1 295 ? 18.22442  -21.90128 -29.60007 1.000 12.59714 ? 376 THR A N   1 
ATOM   3044 C CA  . THR A 1 295 ? 18.70743  -20.53023 -29.57551 1.000 12.98840 ? 376 THR A CA  1 
ATOM   3045 C C   . THR A 1 295 ? 19.51031  -20.12940 -30.79564 1.000 13.20531 ? 376 THR A C   1 
ATOM   3046 O O   . THR A 1 295 ? 19.73004  -18.93037 -30.99140 1.000 16.07052 ? 376 THR A O   1 
ATOM   3047 C CB  . THR A 1 295 ? 19.61902  -20.32473 -28.37242 1.000 11.69339 ? 376 THR A CB  1 
ATOM   3048 O OG1 . THR A 1 295 ? 20.77566  -21.13873 -28.56619 1.000 11.65323 ? 376 THR A OG1 1 
ATOM   3049 C CG2 . THR A 1 295 ? 18.90058  -20.71173 -27.09658 1.000 12.22058 ? 376 THR A CG2 1 
ATOM   3050 N N   . GLY A 1 296 ? 19.97931  -21.08836 -31.58596 1.000 15.00520 ? 377 GLY A N   1 
ATOM   3051 C CA  . GLY A 1 296 ? 20.80382  -20.75731 -32.73282 1.000 17.83590 ? 377 GLY A CA  1 
ATOM   3052 C C   . GLY A 1 296 ? 22.23790  -20.38184 -32.43148 1.000 16.05697 ? 377 GLY A C   1 
ATOM   3053 O O   . GLY A 1 296 ? 22.92429  -19.86678 -33.32282 1.000 18.74846 ? 377 GLY A O   1 
ATOM   3054 N N   . SER A 1 297 ? 22.71935  -20.60296 -31.20832 1.000 12.75705 ? 378 SER A N   1 
ATOM   3055 C CA  . SER A 1 297 ? 24.09335  -20.26266 -30.87289 1.000 13.01600 ? 378 SER A CA  1 
ATOM   3056 C C   . SER A 1 297 ? 24.65928  -21.23533 -29.85576 1.000 12.32381 ? 378 SER A C   1 
ATOM   3057 O O   . SER A 1 297 ? 24.01648  -21.53768 -28.84908 1.000 12.31347 ? 378 SER A O   1 
ATOM   3058 C CB  . SER A 1 297 ? 24.16871  -18.86065 -30.26286 1.000 14.14000 ? 378 SER A CB  1 
ATOM   3059 O OG  . SER A 1 297 ? 25.42363  -18.65024 -29.64475 1.000 13.85956 ? 378 SER A OG  1 
ATOM   3060 N N   . GLN A 1 298 ? 25.90455  -21.65033 -30.09616 1.000 12.49162 ? 379 GLN A N   1 
ATOM   3061 C CA  . GLN A 1 298 ? 26.63382  -22.47314 -29.14443 1.000 12.70154 ? 379 GLN A CA  1 
ATOM   3062 C C   . GLN A 1 298 ? 26.68579  -21.85601 -27.75392 1.000 11.33779 ? 379 GLN A C   1 
ATOM   3063 O O   . GLN A 1 298 ? 26.78900  -22.57139 -26.75439 1.000 13.27930 ? 379 GLN A O   1 
ATOM   3064 C CB  . GLN A 1 298 ? 28.06629  -22.67410 -29.64187 1.000 12.97672 ? 379 GLN A CB  1 
ATOM   3065 C CG  . GLN A 1 298 ? 28.87603  -21.39035 -29.80235 1.000 14.28974 ? 379 GLN A CG  1 
ATOM   3066 C CD  . GLN A 1 298 ? 30.26471  -21.67982 -30.31531 1.000 18.31984 ? 379 GLN A CD  1 
ATOM   3067 O OE1 . GLN A 1 298 ? 31.01667  -22.41846 -29.67774 1.000 20.73331 ? 379 GLN A OE1 1 
ATOM   3068 N NE2 . GLN A 1 298 ? 30.61514  -21.11521 -31.46625 1.000 21.11511 ? 379 GLN A NE2 1 
ATOM   3069 N N   . PHE A 1 299 ? 26.65240  -20.53356 -27.66306 1.000 11.23126 ? 380 PHE A N   1 
ATOM   3070 C CA  . PHE A 1 299 ? 26.86018  -19.87406 -26.38582 1.000 11.18139 ? 380 PHE A CA  1 
ATOM   3071 C C   . PHE A 1 299 ? 25.58540  -19.66144 -25.58208 1.000 10.66573 ? 380 PHE A C   1 
ATOM   3072 O O   . PHE A 1 299 ? 25.68277  -19.29833 -24.40775 1.000 10.97846 ? 380 PHE A O   1 
ATOM   3073 C CB  . PHE A 1 299 ? 27.48329  -18.49458 -26.60281 1.000 11.55803 ? 380 PHE A CB  1 
ATOM   3074 C CG  . PHE A 1 299 ? 28.78135  -18.53447 -27.33120 1.000 12.33703 ? 380 PHE A CG  1 
ATOM   3075 C CD1 . PHE A 1 299 ? 29.85207  -19.22604 -26.79518 1.000 13.65393 ? 380 PHE A CD1 1 
ATOM   3076 C CD2 . PHE A 1 299 ? 28.94287  -17.88989 -28.55247 1.000 13.33019 ? 380 PHE A CD2 1 
ATOM   3077 C CE1 . PHE A 1 299 ? 31.07563  -19.26100 -27.45865 1.000 14.49821 ? 380 PHE A CE1 1 
ATOM   3078 C CE2 . PHE A 1 299 ? 30.16265  -17.93194 -29.21604 1.000 14.60273 ? 380 PHE A CE2 1 
ATOM   3079 C CZ  . PHE A 1 299 ? 31.22052  -18.62021 -28.66743 1.000 14.83348 ? 380 PHE A CZ  1 
ATOM   3080 N N   . ILE A 1 300 ? 24.40650  -19.86491 -26.16821 1.000 10.02502 ? 381 ILE A N   1 
ATOM   3081 C CA  . ILE A 1 300 ? 23.14438  -19.43455 -25.56980 1.000 9.83317  ? 381 ILE A CA  1 
ATOM   3082 C C   . ILE A 1 300 ? 22.34802  -20.66300 -25.15813 1.000 9.00209  ? 381 ILE A C   1 
ATOM   3083 O O   . ILE A 1 300 ? 21.91613  -21.44879 -26.00781 1.000 10.17890 ? 381 ILE A O   1 
ATOM   3084 C CB  . ILE A 1 300 ? 22.34970  -18.52145 -26.51358 1.000 10.39412 ? 381 ILE A CB  1 
ATOM   3085 C CG1 . ILE A 1 300 ? 23.22645  -17.35658 -26.96888 1.000 11.26788 ? 381 ILE A CG1 1 
ATOM   3086 C CG2 . ILE A 1 300 ? 21.09201  -17.98624 -25.81810 1.000 10.25914 ? 381 ILE A CG2 1 
ATOM   3087 C CD1 . ILE A 1 300 ? 22.57140  -16.42735 -27.95874 1.000 12.57735 ? 381 ILE A CD1 1 
ATOM   3088 N N   . ASP A 1 301 ? 22.14748  -20.80669 -23.84705 1.000 9.13149  ? 382 ASP A N   1 
ATOM   3089 C CA  . ASP A 1 301 ? 21.35983  -21.90648 -23.30269 1.000 9.20760  ? 382 ASP A CA  1 
ATOM   3090 C C   . ASP A 1 301 ? 19.87566  -21.72332 -23.57026 1.000 9.04314  ? 382 ASP A C   1 
ATOM   3091 O O   . ASP A 1 301 ? 19.16581  -22.70891 -23.79590 1.000 10.14302 ? 382 ASP A O   1 
ATOM   3092 C CB  . ASP A 1 301 ? 21.58724  -21.99651 -21.79849 1.000 10.85893 ? 382 ASP A CB  1 
ATOM   3093 C CG  . ASP A 1 301 ? 22.96762  -22.46657 -21.43778 1.000 9.68898  ? 382 ASP A CG  1 
ATOM   3094 O OD1 . ASP A 1 301 ? 23.62318  -23.12113 -22.29587 1.000 10.91392 ? 382 ASP A OD1 1 
ATOM   3095 O OD2 . ASP A 1 301 ? 23.39269  -22.17541 -20.29404 1.000 10.14784 ? 382 ASP A OD2 1 
ATOM   3096 N N   . SER A 1 302 ? 19.36994  -20.49297 -23.49493 1.000 9.46470  ? 383 SER A N   1 
ATOM   3097 C CA  . SER A 1 302 ? 17.94068  -20.28675 -23.66534 1.000 9.84926  ? 383 SER A CA  1 
ATOM   3098 C C   . SER A 1 302 ? 17.64757  -18.84534 -24.03965 1.000 9.67176  ? 383 SER A C   1 
ATOM   3099 O O   . SER A 1 302 ? 18.27508  -17.91583 -23.52490 1.000 9.33906  ? 383 SER A O   1 
ATOM   3100 C CB  . SER A 1 302 ? 17.17291  -20.64445 -22.38741 1.000 9.90830  ? 383 SER A CB  1 
ATOM   3101 O OG  . SER A 1 302 ? 15.77874  -20.76289 -22.64393 1.000 10.13127 ? 383 SER A OG  1 
ATOM   3102 N N   . ILE A 1 303 ? 16.66676  -18.68172 -24.92284 1.000 8.85642  ? 384 ILE A N   1 
ATOM   3103 C CA  . ILE A 1 303 ? 15.89143  -17.45455 -24.99169 1.000 9.94576  ? 384 ILE A CA  1 
ATOM   3104 C C   . ILE A 1 303 ? 14.89449  -17.50326 -23.84482 1.000 8.45012  ? 384 ILE A C   1 
ATOM   3105 O O   . ILE A 1 303 ? 14.30570  -18.55994 -23.58578 1.000 9.51292  ? 384 ILE A O   1 
ATOM   3106 C CB  . ILE A 1 303 ? 15.18384  -17.37082 -26.35501 1.000 9.91425  ? 384 ILE A CB  1 
ATOM   3107 C CG1 . ILE A 1 303 ? 16.22412  -17.23154 -27.45955 1.000 11.35158 ? 384 ILE A CG1 1 
ATOM   3108 C CG2 . ILE A 1 303 ? 14.20813  -16.19558 -26.38458 1.000 11.79523 ? 384 ILE A CG2 1 
ATOM   3109 C CD1 . ILE A 1 303 ? 15.68673  -17.46735 -28.86347 1.000 13.61862 ? 384 ILE A CD1 1 
ATOM   3110 N N   . VAL A 1 304 ? 14.72294  -16.38543 -23.13190 1.000 9.21557  ? 385 VAL A N   1 
ATOM   3111 C CA  . VAL A 1 304 ? 13.89715  -16.32650 -21.93043 1.000 9.62554  ? 385 VAL A CA  1 
ATOM   3112 C C   . VAL A 1 304 ? 13.04846  -15.06162 -21.99318 1.000 8.55816  ? 385 VAL A C   1 
ATOM   3113 O O   . VAL A 1 304 ? 13.29385  -14.16627 -22.80202 1.000 9.94798  ? 385 VAL A O   1 
ATOM   3114 C CB  . VAL A 1 304 ? 14.77589  -16.35552 -20.64865 1.000 9.13631  ? 385 VAL A CB  1 
ATOM   3115 C CG1 . VAL A 1 304 ? 15.39143  -17.74881 -20.44127 1.000 10.67735 ? 385 VAL A CG1 1 
ATOM   3116 C CG2 . VAL A 1 304 ? 15.88747  -15.30891 -20.73674 1.000 9.39644  ? 385 VAL A CG2 1 
ATOM   3117 N N   . TRP A 1 305 ? 12.03914  -14.99944 -21.12606 1.000 8.87868  ? 386 TRP A N   1 
ATOM   3118 C CA  . TRP A 1 305 ? 11.26537  -13.78265 -20.89003 1.000 9.24753  ? 386 TRP A CA  1 
ATOM   3119 C C   . TRP A 1 305 ? 11.54327  -13.41809 -19.44126 1.000 8.86485  ? 386 TRP A C   1 
ATOM   3120 O O   . TRP A 1 305 ? 10.95852  -13.98758 -18.51412 1.000 10.10773 ? 386 TRP A O   1 
ATOM   3121 C CB  . TRP A 1 305 ? 9.78023   -14.01591 -21.11783 1.000 9.71730  ? 386 TRP A CB  1 
ATOM   3122 C CG  . TRP A 1 305 ? 9.36560   -14.00962 -22.55559 1.000 9.14239  ? 386 TRP A CG  1 
ATOM   3123 C CD1 . TRP A 1 305 ? 10.14492  -14.20558 -23.64875 1.000 9.81645  ? 386 TRP A CD1 1 
ATOM   3124 C CD2 . TRP A 1 305 ? 8.03439   -13.84370 -23.03777 1.000 10.19955 ? 386 TRP A CD2 1 
ATOM   3125 N NE1 . TRP A 1 305 ? 9.39048   -14.14439 -24.79379 1.000 10.11047 ? 386 TRP A NE1 1 
ATOM   3126 C CE2 . TRP A 1 305 ? 8.08147   -13.93190 -24.43961 1.000 10.73379 ? 386 TRP A CE2 1 
ATOM   3127 C CE3 . TRP A 1 305 ? 6.80006   -13.62658 -22.41155 1.000 11.13743 ? 386 TRP A CE3 1 
ATOM   3128 C CZ2 . TRP A 1 305 ? 6.93268   -13.77904 -25.23682 1.000 12.41200 ? 386 TRP A CZ2 1 
ATOM   3129 C CZ3 . TRP A 1 305 ? 5.66626   -13.47930 -23.19296 1.000 11.52309 ? 386 TRP A CZ3 1 
ATOM   3130 C CH2 . TRP A 1 305 ? 5.73520   -13.56469 -24.59106 1.000 11.80332 ? 386 TRP A CH2 1 
ATOM   3131 N N   . VAL A 1 306 ? 12.48997  -12.51024 -19.23209 1.000 9.16848  ? 387 VAL A N   1 
ATOM   3132 C CA  . VAL A 1 306 ? 12.89519  -12.15663 -17.87350 1.000 9.22627  ? 387 VAL A CA  1 
ATOM   3133 C C   . VAL A 1 306 ? 11.99321  -11.05284 -17.34172 1.000 8.82364  ? 387 VAL A C   1 
ATOM   3134 O O   . VAL A 1 306 ? 11.26635  -11.24871 -16.35776 1.000 9.26501  ? 387 VAL A O   1 
ATOM   3135 C CB  . VAL A 1 306 ? 14.38918  -11.79347 -17.75857 1.000 9.01714  ? 387 VAL A CB  1 
ATOM   3136 C CG1 . VAL A 1 306 ? 14.74801  -11.59593 -16.29147 1.000 10.10329 ? 387 VAL A CG1 1 
ATOM   3137 C CG2 . VAL A 1 306 ? 15.22767  -12.88148 -18.36781 1.000 10.68520 ? 387 VAL A CG2 1 
ATOM   3138 N N   . LYS A 1 307 ? 12.02558  -9.88848  -17.98072 1.000 9.75204  ? 388 LYS A N   1 
ATOM   3139 C CA  . LYS A 1 307 ? 11.07057  -8.83752  -17.64295 1.000 9.64307  ? 388 LYS A CA  1 
ATOM   3140 C C   . LYS A 1 307 ? 9.67152   -9.26386  -18.08387 1.000 11.04298 ? 388 LYS A C   1 
ATOM   3141 O O   . LYS A 1 307 ? 9.47949   -9.62174  -19.25222 1.000 11.21934 ? 388 LYS A O   1 
ATOM   3142 C CB  . LYS A 1 307 ? 11.47282  -7.57058  -18.39130 1.000 10.52553 ? 388 LYS A CB  1 
ATOM   3143 C CG  . LYS A 1 307 ? 10.42901  -6.45442  -18.37896 1.000 11.28617 ? 388 LYS A CG  1 
ATOM   3144 C CD  . LYS A 1 307 ? 10.29641  -5.81188  -17.02281 1.000 12.11021 ? 388 LYS A CD  1 
ATOM   3145 C CE  . LYS A 1 307 ? 9.15678   -4.81516  -17.04250 1.000 12.90836 ? 388 LYS A CE  1 
ATOM   3146 N NZ  . LYS A 1 307 ? 9.04775   -4.06165  -15.76121 1.000 16.82055 ? 388 LYS A NZ  1 
ATOM   3147 N N   . PRO A 1 308 ? 8.66551   -9.23862  -17.19397 1.000 10.72228 ? 389 PRO A N   1 
ATOM   3148 C CA  . PRO A 1 308 ? 7.31979   -9.67490  -17.59091 1.000 11.92179 ? 389 PRO A CA  1 
ATOM   3149 C C   . PRO A 1 308 ? 6.59863   -8.55524  -18.32105 1.000 11.56662 ? 389 PRO A C   1 
ATOM   3150 O O   . PRO A 1 308 ? 6.23310   -7.53869  -17.72056 1.000 12.56894 ? 389 PRO A O   1 
ATOM   3151 C CB  . PRO A 1 308 ? 6.65321   -10.01591 -16.24367 1.000 13.79036 ? 389 PRO A CB  1 
ATOM   3152 C CG  . PRO A 1 308 ? 7.79206   -10.01708 -15.21688 1.000 13.91083 ? 389 PRO A CG  1 
ATOM   3153 C CD  . PRO A 1 308 ? 8.74532   -9.01252  -15.74470 1.000 11.88185 ? 389 PRO A CD  1 
ATOM   3154 N N   . GLY A 1 309 ? 6.43903   -8.72103  -19.63494 1.000 11.90008 ? 390 GLY A N   1 
ATOM   3155 C CA  . GLY A 1 309 ? 5.79510   -7.71011  -20.45299 1.000 11.85767 ? 390 GLY A CA  1 
ATOM   3156 C C   . GLY A 1 309 ? 4.40149   -7.38005  -19.96222 1.000 12.39349 ? 390 GLY A C   1 
ATOM   3157 O O   . GLY A 1 309 ? 3.57720   -8.27993  -19.74472 1.000 13.28944 ? 390 GLY A O   1 
ATOM   3158 N N   . GLY A 1 310 ? 4.12745   -6.08867  -19.78324 1.000 12.73437 ? 391 GLY A N   1 
ATOM   3159 C CA  . GLY A 1 310 ? 2.89980   -5.61404  -19.18287 1.000 13.77865 ? 391 GLY A CA  1 
ATOM   3160 C C   . GLY A 1 310 ? 3.10511   -4.94307  -17.84119 1.000 14.27250 ? 391 GLY A C   1 
ATOM   3161 O O   . GLY A 1 310 ? 2.27363   -4.12175  -17.43767 1.000 15.07537 ? 391 GLY A O   1 
ATOM   3162 N N   . GLU A 1 311 ? 4.18176   -5.27597  -17.13435 1.000 14.30212 ? 392 GLU A N   1 
ATOM   3163 C CA  . GLU A 1 311 ? 4.54003   -4.57087  -15.91495 1.000 14.48216 ? 392 GLU A CA  1 
ATOM   3164 C C   . GLU A 1 311 ? 5.38754   -3.35256  -16.26617 1.000 13.79920 ? 392 GLU A C   1 
ATOM   3165 O O   . GLU A 1 311 ? 6.35427   -3.45861  -17.02902 1.000 13.40997 ? 392 GLU A O   1 
ATOM   3166 C CB  . GLU A 1 311 ? 5.27980   -5.50908  -14.96185 1.000 16.08203 ? 392 GLU A CB  1 
ATOM   3167 C CG  . GLU A 1 311 ? 4.40577   -6.67767  -14.53598 1.000 15.11422 ? 392 GLU A CG  1 
ATOM   3168 C CD  . GLU A 1 311 ? 5.13127   -7.69690  -13.68018 1.000 14.76737 ? 392 GLU A CD  1 
ATOM   3169 O OE1 . GLU A 1 311 ? 6.31316   -7.48002  -13.34092 1.000 16.61866 ? 392 GLU A OE1 1 
ATOM   3170 O OE2 . GLU A 1 311 ? 4.50179   -8.71858  -13.34317 1.000 16.24024 ? 392 GLU A OE2 1 
ATOM   3171 N N   . SER A 1 312 ? 5.01948   -2.19577  -15.71689 1.000 13.30580 ? 393 SER A N   1 
ATOM   3172 C CA  . SER A 1 312 ? 5.66659   -0.94408  -16.07875 1.000 13.64644 ? 393 SER A CA  1 
ATOM   3173 C C   . SER A 1 312 ? 7.13766   -0.94289  -15.66267 1.000 14.15087 ? 393 SER A C   1 
ATOM   3174 O O   . SER A 1 312 ? 7.53097   -1.56488  -14.66847 1.000 15.43259 ? 393 SER A O   1 
ATOM   3175 C CB  . SER A 1 312 ? 4.94477   0.22123   -15.39552 1.000 14.59509 ? 393 SER A CB  1 
ATOM   3176 O OG  . SER A 1 312 ? 5.59733   1.45281   -15.64562 1.000 14.40241 ? 393 SER A OG  1 
ATOM   3177 N N   . ASP A 1 313 ? 7.95532   -0.22657  -16.43930 1.000 13.12223 ? 394 ASP A N   1 
ATOM   3178 C CA  . ASP A 1 313 ? 9.34289   0.04902   -16.08280 1.000 12.88392 ? 394 ASP A CA  1 
ATOM   3179 C C   . ASP A 1 313 ? 9.49176   1.25061   -15.16062 1.000 14.27719 ? 394 ASP A C   1 
ATOM   3180 O O   . ASP A 1 313 ? 10.59104  1.48899   -14.64271 1.000 15.35330 ? 394 ASP A O   1 
ATOM   3181 C CB  . ASP A 1 313 ? 10.16351  0.31491   -17.34414 1.000 12.61813 ? 394 ASP A CB  1 
ATOM   3182 C CG  . ASP A 1 313 ? 10.16277  -0.84925  -18.30049 1.000 12.86403 ? 394 ASP A CG  1 
ATOM   3183 O OD1 . ASP A 1 313 ? 10.33500  -2.00027  -17.83515 1.000 14.68603 ? 394 ASP A OD1 1 
ATOM   3184 O OD2 . ASP A 1 313 ? 10.00846  -0.62118  -19.51372 1.000 12.12520 ? 394 ASP A OD2 1 
ATOM   3185 N N   . GLY A 1 314 ? 8.42684   2.02394   -14.95528 1.000 14.19634 ? 395 GLY A N   1 
ATOM   3186 C CA  . GLY A 1 314 ? 8.50461   3.23513   -14.16776 1.000 14.98261 ? 395 GLY A CA  1 
ATOM   3187 C C   . GLY A 1 314 ? 7.40066   4.21144   -14.51373 1.000 15.49365 ? 395 GLY A C   1 
ATOM   3188 O O   . GLY A 1 314 ? 6.86558   4.20396   -15.62420 1.000 15.11336 ? 395 GLY A O   1 
ATOM   3189 N N   . THR A 1 315 ? 7.06151   5.06816   -13.55909 1.000 15.33031 ? 396 THR A N   1 
ATOM   3190 C CA  . THR A 1 315 ? 5.98727   6.02420   -13.76024 1.000 17.41739 ? 396 THR A CA  1 
ATOM   3191 C C   . THR A 1 315 ? 6.44420   7.16013   -14.66486 1.000 16.21175 ? 396 THR A C   1 
ATOM   3192 O O   . THR A 1 315 ? 7.61559   7.53492   -14.68417 1.000 17.09372 ? 396 THR A O   1 
ATOM   3193 C CB  . THR A 1 315 ? 5.54510   6.59467   -12.41188 1.000 16.16824 ? 396 THR A CB  1 
ATOM   3194 O OG1 . THR A 1 315 ? 4.48368   7.53994   -12.60847 1.000 20.53331 ? 396 THR A OG1 1 
ATOM   3195 C CG2 . THR A 1 315 ? 6.70944   7.28668   -11.71501 1.000 19.76067 ? 396 THR A CG2 1 
ATOM   3196 N N   . SER A 1 316 ? 5.49319   7.72460   -15.40895 1.000 16.35633 ? 397 SER A N   1 
ATOM   3197 C CA  . SER A 1 316 ? 5.74076   8.94613   -16.16290 1.000 18.41348 ? 397 SER A CA  1 
ATOM   3198 C C   . SER A 1 316 ? 5.34976   10.20384  -15.39468 1.000 17.50151 ? 397 SER A C   1 
ATOM   3199 O O   . SER A 1 316 ? 5.45541   11.30433  -15.94463 1.000 20.88974 ? 397 SER A O   1 
ATOM   3200 C CB  . SER A 1 316 ? 4.99424   8.91412   -17.50011 1.000 19.08233 ? 397 SER A CB  1 
ATOM   3201 O OG  . SER A 1 316 ? 3.60458   8.76573   -17.29252 1.000 19.56464 ? 397 SER A OG  1 
ATOM   3202 N N   . ASN A 1 317 ? 4.91547   10.06960  -14.14761 1.000 17.34975 ? 398 ASN A N   1 
ATOM   3203 C CA  . ASN A 1 317 ? 4.44763   11.20153  -13.35233 1.000 18.52988 ? 398 ASN A CA  1 
ATOM   3204 C C   . ASN A 1 317 ? 5.65420   11.83806  -12.67086 1.000 23.61974 ? 398 ASN A C   1 
ATOM   3205 O O   . ASN A 1 317 ? 6.23437   11.25417  -11.74987 1.000 20.71714 ? 398 ASN A O   1 
ATOM   3206 C CB  . ASN A 1 317 ? 3.45522   10.70613  -12.30464 1.000 20.21170 ? 398 ASN A CB  1 
ATOM   3207 C CG  . ASN A 1 317 ? 2.83885   11.83735  -11.48759 1.000 24.78350 ? 398 ASN A CG  1 
ATOM   3208 O OD1 . ASN A 1 317 ? 3.38743   12.93771  -11.40113 1.000 23.28187 ? 398 ASN A OD1 1 
ATOM   3209 N ND2 . ASN A 1 317 ? 1.70566   11.55042  -10.85304 1.000 36.94920 ? 398 ASN A ND2 1 
ATOM   3210 N N   . SER A 1 318 ? 5.99898   13.06117  -13.08357 1.000 23.23396 ? 399 SER A N   1 
ATOM   3211 C CA  . SER A 1 318 ? 7.17656   13.73405  -12.54399 1.000 25.76754 ? 399 SER A CA  1 
ATOM   3212 C C   . SER A 1 318 ? 7.02908   14.13391  -11.08043 1.000 22.41664 ? 399 SER A C   1 
ATOM   3213 O O   . SER A 1 318 ? 8.01258   14.58432  -10.48313 1.000 29.80986 ? 399 SER A O   1 
ATOM   3214 C CB  . SER A 1 318 ? 7.55842   14.94210  -13.40535 1.000 26.73451 ? 399 SER A CB  1 
ATOM   3215 O OG  . SER A 1 318 ? 6.48062   15.84923  -13.53962 1.000 26.33642 ? 399 SER A OG  1 
ATOM   3216 N N   . SER A 1 319 ? 5.84743   13.96980  -10.48984 1.000 22.91666 ? 400 SER A N   1 
ATOM   3217 C CA  . SER A 1 319 ? 5.64221   14.23309  -9.07297  1.000 22.38810 ? 400 SER A CA  1 
ATOM   3218 C C   . SER A 1 319 ? 5.95383   13.03430  -8.18855  1.000 27.55363 ? 400 SER A C   1 
ATOM   3219 O O   . SER A 1 319 ? 5.99718   13.18499  -6.96395  1.000 28.19156 ? 400 SER A O   1 
ATOM   3220 C CB  . SER A 1 319 ? 4.20138   14.68569  -8.82176  1.000 29.24053 ? 400 SER A CB  1 
ATOM   3221 O OG  . SER A 1 319 ? 3.89606   15.83175  -9.59586  1.000 29.45976 ? 400 SER A OG  1 
ATOM   3222 N N   . SER A 1 320 ? 6.17489   11.85932  -8.76508  1.000 23.22776 ? 401 SER A N   1 
ATOM   3223 C CA  . SER A 1 320 ? 6.42971   10.68642  -7.94779  1.000 25.21842 ? 401 SER A CA  1 
ATOM   3224 C C   . SER A 1 320 ? 7.84508   10.74069  -7.37930  1.000 21.31209 ? 401 SER A C   1 
ATOM   3225 O O   . SER A 1 320 ? 8.78302   11.13889  -8.07785  1.000 21.88724 ? 401 SER A O   1 
ATOM   3226 C CB  . SER A 1 320 ? 6.26897   9.41569   -8.77672  1.000 22.19695 ? 401 SER A CB  1 
ATOM   3227 O OG  . SER A 1 320 ? 6.81452   8.30269   -8.08830  1.000 23.52204 ? 401 SER A OG  1 
ATOM   3228 N N   . PRO A 1 321 ? 8.03314   10.33823  -6.11980  1.000 23.74090 ? 402 PRO A N   1 
ATOM   3229 C CA  . PRO A 1 321 ? 9.39734   10.22962  -5.58037  1.000 24.26454 ? 402 PRO A CA  1 
ATOM   3230 C C   . PRO A 1 321 ? 10.25703  9.21789   -6.31775  1.000 24.07864 ? 402 PRO A C   1 
ATOM   3231 O O   . PRO A 1 321 ? 11.48684  9.26662   -6.19471  1.000 26.62224 ? 402 PRO A O   1 
ATOM   3232 C CB  . PRO A 1 321 ? 9.16635   9.82088   -4.11951  1.000 26.07803 ? 402 PRO A CB  1 
ATOM   3233 C CG  . PRO A 1 321 ? 7.81799   9.16813   -4.12004  1.000 29.03940 ? 402 PRO A CG  1 
ATOM   3234 C CD  . PRO A 1 321 ? 7.01289   9.90940   -5.14848  1.000 26.77798 ? 402 PRO A CD  1 
ATOM   3235 N N   A ARG A 1 322 ? 9.66971   8.31182   -7.09831  0.703 21.88594 ? 403 ARG A N   1 
ATOM   3236 N N   B ARG A 1 322 ? 9.63003   8.31381   -7.07242  0.297 22.03431 ? 403 ARG A N   1 
ATOM   3237 C CA  A ARG A 1 322 ? 10.43397  7.31335   -7.83687  0.703 24.57746 ? 403 ARG A CA  1 
ATOM   3238 C CA  B ARG A 1 322 ? 10.28930  7.28146   -7.85612  0.297 24.72398 ? 403 ARG A CA  1 
ATOM   3239 C C   A ARG A 1 322 ? 10.68182  7.70912   -9.29102  0.703 21.53688 ? 403 ARG A C   1 
ATOM   3240 C C   B ARG A 1 322 ? 10.31964  7.61778   -9.34305  0.297 23.08238 ? 403 ARG A C   1 
ATOM   3241 O O   A ARG A 1 322 ? 11.30382  6.94421   -10.03511 0.703 17.63546 ? 403 ARG A O   1 
ATOM   3242 O O   B ARG A 1 322 ? 10.40326  6.70959   -10.17664 0.297 24.04516 ? 403 ARG A O   1 
ATOM   3243 C CB  A ARG A 1 322 ? 9.73748   5.95222   -7.76013  0.703 25.39855 ? 403 ARG A CB  1 
ATOM   3244 C CB  B ARG A 1 322 ? 9.58347   5.94126   -7.63573  0.297 25.73420 ? 403 ARG A CB  1 
ATOM   3245 C CG  A ARG A 1 322 ? 9.71262   5.33662   -6.36173  0.703 27.60820 ? 403 ARG A CG  1 
ATOM   3246 C CG  B ARG A 1 322 ? 10.50735  4.74072   -7.61513  0.297 30.83852 ? 403 ARG A CG  1 
ATOM   3247 C CD  A ARG A 1 322 ? 9.90285   3.82617   -6.42301  0.703 32.43373 ? 403 ARG A CD  1 
ATOM   3248 C CD  B ARG A 1 322 ? 9.78305   3.44363   -7.97072  0.297 28.82337 ? 403 ARG A CD  1 
ATOM   3249 N NE  A ARG A 1 322 ? 10.83379  3.45177   -7.48078  0.703 34.14023 ? 403 ARG A NE  1 
ATOM   3250 N NE  B ARG A 1 322 ? 8.48343   3.31795   -7.31955  0.297 29.08103 ? 403 ARG A NE  1 
ATOM   3251 C CZ  A ARG A 1 322 ? 10.90376  2.25093   -8.03924  0.703 27.64214 ? 403 ARG A CZ  1 
ATOM   3252 C CZ  B ARG A 1 322 ? 7.69986   2.25160   -7.41431  0.297 26.98910 ? 403 ARG A CZ  1 
ATOM   3253 N NH1 A ARG A 1 322 ? 10.11315  1.26044   -7.65581  0.703 30.41970 ? 403 ARG A NH1 1 
ATOM   3254 N NH1 B ARG A 1 322 ? 8.05929   1.18901   -8.11653  0.297 23.32550 ? 403 ARG A NH1 1 
ATOM   3255 N NH2 A ARG A 1 322 ? 11.78513  2.04077   -9.01268  0.703 34.28147 ? 403 ARG A NH2 1 
ATOM   3256 N NH2 B ARG A 1 322 ? 6.52736   2.25042   -6.78721  0.297 24.99882 ? 403 ARG A NH2 1 
ATOM   3257 N N   . TYR A 1 323 ? 10.24084  8.89916   -9.69414  1.000 21.73664 ? 404 TYR A N   1 
ATOM   3258 C CA  . TYR A 1 323 ? 10.22188  9.29153   -11.09781 1.000 18.37501 ? 404 TYR A CA  1 
ATOM   3259 C C   . TYR A 1 323 ? 11.61923  9.34555   -11.70438 1.000 19.12961 ? 404 TYR A C   1 
ATOM   3260 O O   . TYR A 1 323 ? 12.54485  9.93415   -11.12993 1.000 22.09578 ? 404 TYR A O   1 
ATOM   3261 C CB  . TYR A 1 323 ? 9.55463   10.65793  -11.21746 1.000 21.33593 ? 404 TYR A CB  1 
ATOM   3262 C CG  . TYR A 1 323 ? 9.62462   11.28915  -12.58451 1.000 20.67553 ? 404 TYR A CG  1 
ATOM   3263 C CD1 . TYR A 1 323 ? 8.85686   10.79666  -13.63183 1.000 19.06257 ? 404 TYR A CD1 1 
ATOM   3264 C CD2 . TYR A 1 323 ? 10.41651  12.40440  -12.81804 1.000 20.87650 ? 404 TYR A CD2 1 
ATOM   3265 C CE1 . TYR A 1 323 ? 8.89512   11.37687  -14.87948 1.000 19.98041 ? 404 TYR A CE1 1 
ATOM   3266 C CE2 . TYR A 1 323 ? 10.46039  12.99832  -14.06959 1.000 20.82392 ? 404 TYR A CE2 1 
ATOM   3267 C CZ  . TYR A 1 323 ? 9.69144   12.47656  -15.09440 1.000 20.09215 ? 404 TYR A CZ  1 
ATOM   3268 O OH  . TYR A 1 323 ? 9.72430   13.06113  -16.34030 1.000 22.79575 ? 404 TYR A OH  1 
ATOM   3269 N N   . ASP A 1 324 ? 11.75219  8.73736   -12.88227 1.000 17.38498 ? 405 ASP A N   1 
ATOM   3270 C CA  . ASP A 1 324 ? 12.94409  8.79365   -13.71520 1.000 17.80779 ? 405 ASP A CA  1 
ATOM   3271 C C   . ASP A 1 324 ? 12.51065  9.43794   -15.02353 1.000 15.70674 ? 405 ASP A C   1 
ATOM   3272 O O   . ASP A 1 324 ? 11.58562  8.94485   -15.68031 1.000 17.18848 ? 405 ASP A O   1 
ATOM   3273 C CB  . ASP A 1 324 ? 13.44301  7.36992   -13.97731 1.000 18.49652 ? 405 ASP A CB  1 
ATOM   3274 C CG  . ASP A 1 324 ? 14.80797  7.32912   -14.63355 1.000 20.37800 ? 405 ASP A CG  1 
ATOM   3275 O OD1 . ASP A 1 324 ? 15.04320  8.06711   -15.61798 1.000 20.30257 ? 405 ASP A OD1 1 
ATOM   3276 O OD2 . ASP A 1 324 ? 15.64698  6.52247   -14.17839 1.000 22.62197 ? 405 ASP A OD2 1 
ATOM   3277 N N   . SER A 1 325 ? 13.16764  10.53911  -15.39555 1.000 18.46378 ? 406 SER A N   1 
ATOM   3278 C CA  . SER A 1 325 ? 12.76636  11.29569  -16.57878 1.000 17.92381 ? 406 SER A CA  1 
ATOM   3279 C C   . SER A 1 325 ? 12.84801  10.48604  -17.86847 1.000 16.29511 ? 406 SER A C   1 
ATOM   3280 O O   . SER A 1 325 ? 12.21382  10.86530  -18.85887 1.000 17.22849 ? 406 SER A O   1 
ATOM   3281 C CB  . SER A 1 325 ? 13.60515  12.57251  -16.69949 1.000 18.42309 ? 406 SER A CB  1 
ATOM   3282 O OG  . SER A 1 325 ? 14.95066  12.26932  -17.02071 1.000 22.20155 ? 406 SER A OG  1 
ATOM   3283 N N   . THR A 1 326 ? 13.60415  9.38302   -17.88136 1.000 16.98781 ? 407 THR A N   1 
ATOM   3284 C CA  . THR A 1 326 ? 13.61169  8.50306   -19.04742 1.000 16.91620 ? 407 THR A CA  1 
ATOM   3285 C C   . THR A 1 326 ? 12.20481  8.03869   -19.39839 1.000 14.86141 ? 407 THR A C   1 
ATOM   3286 O O   . THR A 1 326 ? 11.89887  7.79802   -20.57293 1.000 15.25772 ? 407 THR A O   1 
ATOM   3287 C CB  . THR A 1 326 ? 14.53044  7.30804   -18.77402 1.000 16.17198 ? 407 THR A CB  1 
ATOM   3288 O OG1 . THR A 1 326 ? 15.83020  7.78126   -18.39463 1.000 22.03117 ? 407 THR A OG1 1 
ATOM   3289 C CG2 . THR A 1 326 ? 14.65791  6.41030   -20.00564 1.000 17.48752 ? 407 THR A CG2 1 
ATOM   3290 N N   . CYS A 1 327 ? 11.33389  7.94397   -18.40222 1.000 14.33163 ? 408 CYS A N   1 
ATOM   3291 C CA  . CYS A 1 327 ? 9.97993   7.44439   -18.57485 1.000 14.59409 ? 408 CYS A CA  1 
ATOM   3292 C C   . CYS A 1 327 ? 9.01993   8.48306   -19.14289 1.000 15.09715 ? 408 CYS A C   1 
ATOM   3293 O O   . CYS A 1 327 ? 7.84468   8.17063   -19.34826 1.000 15.28044 ? 408 CYS A O   1 
ATOM   3294 C CB  . CYS A 1 327 ? 9.48323   6.87062   -17.25076 1.000 16.37661 ? 408 CYS A CB  1 
ATOM   3295 S SG  . CYS A 1 327 ? 10.48392  5.47997   -16.68831 1.000 15.45568 ? 408 CYS A SG  1 
ATOM   3296 N N   . SER A 1 328 ? 9.48450   9.69902   -19.42114 1.000 15.50546 ? 409 SER A N   1 
ATOM   3297 C CA  A SER A 1 328 ? 8.68813   10.71428  -20.09591 0.605 16.85063 ? 409 SER A CA  1 
ATOM   3298 C CA  B SER A 1 328 ? 8.64970   10.66757  -20.12175 0.395 16.86169 ? 409 SER A CA  1 
ATOM   3299 C C   . SER A 1 328 ? 9.22183   11.05796  -21.47854 1.000 18.84193 ? 409 SER A C   1 
ATOM   3300 O O   . SER A 1 328 ? 8.69988   11.98290  -22.11486 1.000 19.91673 ? 409 SER A O   1 
ATOM   3301 C CB  A SER A 1 328 ? 8.60879   11.99369  -19.25178 0.605 17.12444 ? 409 SER A CB  1 
ATOM   3302 C CB  B SER A 1 328 ? 8.35146   11.90356  -19.26248 0.395 16.44262 ? 409 SER A CB  1 
ATOM   3303 O OG  A SER A 1 328 ? 7.88385   11.78352  -18.05901 0.605 18.98019 ? 409 SER A OG  1 
ATOM   3304 O OG  B SER A 1 328 ? 9.53437   12.60550  -18.93719 0.395 14.17280 ? 409 SER A OG  1 
ATOM   3305 N N   . LEU A 1 329 ? 10.26146  10.36038  -21.95042 1.000 16.82170 ? 410 LEU A N   1 
ATOM   3306 C CA  . LEU A 1 329 ? 10.83461  10.63782  -23.25400 1.000 17.59961 ? 410 LEU A CA  1 
ATOM   3307 C C   . LEU A 1 329 ? 9.80478   10.43102  -24.35954 1.000 19.64349 ? 410 LEU A C   1 
ATOM   3308 O O   . LEU A 1 329 ? 8.81032   9.72715   -24.17167 1.000 17.60071 ? 410 LEU A O   1 
ATOM   3309 C CB  . LEU A 1 329 ? 12.02471  9.72276   -23.51330 1.000 17.00410 ? 410 LEU A CB  1 
ATOM   3310 C CG  . LEU A 1 329 ? 13.28412  10.06536  -22.73810 1.000 16.29749 ? 410 LEU A CG  1 
ATOM   3311 C CD1 . LEU A 1 329 ? 14.35122  9.04072   -23.03754 1.000 18.33781 ? 410 LEU A CD1 1 
ATOM   3312 C CD2 . LEU A 1 329 ? 13.73937  11.47213  -23.11949 1.000 18.93905 ? 410 LEU A CD2 1 
ATOM   3313 N N   . PRO A 1 330 ? 10.03457  11.03827  -25.52984 1.000 22.29622 ? 411 PRO A N   1 
ATOM   3314 C CA  . PRO A 1 330 ? 9.07746   10.88917  -26.63959 1.000 21.14215 ? 411 PRO A CA  1 
ATOM   3315 C C   . PRO A 1 330 ? 8.75916   9.45161   -27.02778 1.000 23.59602 ? 411 PRO A C   1 
ATOM   3316 O O   . PRO A 1 330 ? 7.64493   9.18886   -27.49688 1.000 22.43663 ? 411 PRO A O   1 
ATOM   3317 C CB  . PRO A 1 330 ? 9.72371   11.67221  -27.79244 1.000 22.50229 ? 411 PRO A CB  1 
ATOM   3318 C CG  . PRO A 1 330 ? 10.72677  12.57225  -27.16419 1.000 29.27238 ? 411 PRO A CG  1 
ATOM   3319 C CD  . PRO A 1 330 ? 11.05668  12.06980  -25.79122 1.000 22.85159 ? 411 PRO A CD  1 
ATOM   3320 N N   . ASP A 1 331 ? 9.68668   8.51340   -26.85334 1.000 17.64701 ? 412 ASP A N   1 
ATOM   3321 C CA  . ASP A 1 331 ? 9.42677   7.12646   -27.21858 1.000 17.00692 ? 412 ASP A CA  1 
ATOM   3322 C C   . ASP A 1 331 ? 8.94134   6.27166   -26.04976 1.000 15.88555 ? 412 ASP A C   1 
ATOM   3323 O O   . ASP A 1 331 ? 8.83963   5.04528   -26.19399 1.000 15.27373 ? 412 ASP A O   1 
ATOM   3324 C CB  . ASP A 1 331 ? 10.64586  6.50181   -27.90905 1.000 17.47426 ? 412 ASP A CB  1 
ATOM   3325 C CG  . ASP A 1 331 ? 11.93056  6.66103   -27.11466 1.000 14.62165 ? 412 ASP A CG  1 
ATOM   3326 O OD1 . ASP A 1 331 ? 11.89218  7.17776   -25.97632 1.000 18.84365 ? 412 ASP A OD1 1 
ATOM   3327 O OD2 . ASP A 1 331 ? 12.98893  6.25661   -27.64784 1.000 15.44997 ? 412 ASP A OD2 1 
ATOM   3328 N N   . ALA A 1 332 ? 8.63734   6.88199   -24.90821 1.000 15.20713 ? 413 ALA A N   1 
ATOM   3329 C CA  . ALA A 1 332 ? 8.10216   6.17739   -23.75061 1.000 13.85518 ? 413 ALA A CA  1 
ATOM   3330 C C   . ALA A 1 332 ? 6.58118   6.29598   -23.73148 1.000 15.00513 ? 413 ALA A C   1 
ATOM   3331 O O   . ALA A 1 332 ? 6.03620   7.40066   -23.86686 1.000 17.49952 ? 413 ALA A O   1 
ATOM   3332 C CB  . ALA A 1 332 ? 8.68197   6.75317   -22.46115 1.000 14.23736 ? 413 ALA A CB  1 
ATOM   3333 N N   . ALA A 1 333 ? 5.89755   5.16625   -23.56171 1.000 14.28726 ? 414 ALA A N   1 
ATOM   3334 C CA  . ALA A 1 333 ? 4.44182   5.16627   -23.50080 1.000 14.91783 ? 414 ALA A CA  1 
ATOM   3335 C C   . ALA A 1 333 ? 3.96471   5.87838   -22.24145 1.000 15.69780 ? 414 ALA A C   1 
ATOM   3336 O O   . ALA A 1 333 ? 4.40702   5.56597   -21.13142 1.000 16.93348 ? 414 ALA A O   1 
ATOM   3337 C CB  . ALA A 1 333 ? 3.91463   3.73143   -23.52740 1.000 16.04654 ? 414 ALA A CB  1 
ATOM   3338 N N   . GLN A 1 334 ? 3.04427   6.82787   -22.41534 1.000 15.19686 ? 415 GLN A N   1 
ATOM   3339 C CA  . GLN A 1 334 ? 2.56064   7.68226   -21.33792 1.000 17.27171 ? 415 GLN A CA  1 
ATOM   3340 C C   . GLN A 1 334 ? 1.05637   7.86838   -21.46291 1.000 17.91066 ? 415 GLN A C   1 
ATOM   3341 O O   . GLN A 1 334 ? 0.52025   7.86239   -22.57728 1.000 22.59750 ? 415 GLN A O   1 
ATOM   3342 C CB  . GLN A 1 334 ? 3.19540   9.07346   -21.42814 1.000 22.49143 ? 415 GLN A CB  1 
ATOM   3343 C CG  . GLN A 1 334 ? 4.68261   9.11100   -21.21420 1.000 22.49248 ? 415 GLN A CG  1 
ATOM   3344 C CD  . GLN A 1 334 ? 5.28684   10.37060  -21.79303 1.000 25.18633 ? 415 GLN A CD  1 
ATOM   3345 O OE1 . GLN A 1 334 ? 4.89294   11.48055  -21.43018 1.000 26.77151 ? 415 GLN A OE1 1 
ATOM   3346 N NE2 . GLN A 1 334 ? 6.24934   10.21061  -22.69484 1.000 21.57234 ? 415 GLN A NE2 1 
ATOM   3347 N N   . PRO A 1 335 ? 0.34473   8.03548   -20.33363 1.000 18.01577 ? 416 PRO A N   1 
ATOM   3348 C CA  . PRO A 1 335 ? 0.86829   7.97215   -18.96316 1.000 18.70359 ? 416 PRO A CA  1 
ATOM   3349 C C   . PRO A 1 335 ? 1.16169   6.53436   -18.53950 1.000 16.24431 ? 416 PRO A C   1 
ATOM   3350 O O   . PRO A 1 335 ? 0.45908   5.61427   -18.95484 1.000 17.69555 ? 416 PRO A O   1 
ATOM   3351 C CB  . PRO A 1 335 ? -0.28254  8.54117   -18.12630 1.000 19.65713 ? 416 PRO A CB  1 
ATOM   3352 C CG  . PRO A 1 335 ? -1.49733  8.23434   -18.91958 1.000 22.26801 ? 416 PRO A CG  1 
ATOM   3353 C CD  . PRO A 1 335 ? -1.08881  8.38330   -20.35515 1.000 22.00784 ? 416 PRO A CD  1 
ATOM   3354 N N   . ALA A 1 336 ? 2.20237   6.35165   -17.72564 1.000 18.09978 ? 417 ALA A N   1 
ATOM   3355 C CA  . ALA A 1 336 ? 2.61001   5.02780   -17.29130 1.000 17.10288 ? 417 ALA A CA  1 
ATOM   3356 C C   . ALA A 1 336 ? 2.59472   4.95332   -15.77007 1.000 17.32549 ? 417 ALA A C   1 
ATOM   3357 O O   . ALA A 1 336 ? 2.91838   5.94151   -15.10053 1.000 18.39677 ? 417 ALA A O   1 
ATOM   3358 C CB  . ALA A 1 336 ? 4.02669   4.70688   -17.79482 1.000 16.11445 ? 417 ALA A CB  1 
ATOM   3359 N N   . PRO A 1 337 ? 2.21528   3.80050   -15.19500 1.000 16.42852 ? 418 PRO A N   1 
ATOM   3360 C CA  . PRO A 1 337 ? 2.14540   3.68442   -13.73170 1.000 18.85944 ? 418 PRO A CA  1 
ATOM   3361 C C   . PRO A 1 337 ? 3.48548   3.31206   -13.11613 1.000 18.09904 ? 418 PRO A C   1 
ATOM   3362 O O   . PRO A 1 337 ? 4.47922   3.15961   -13.83512 1.000 16.81070 ? 418 PRO A O   1 
ATOM   3363 C CB  . PRO A 1 337 ? 1.12418   2.56256   -13.53223 1.000 18.63387 ? 418 PRO A CB  1 
ATOM   3364 C CG  . PRO A 1 337 ? 1.39904   1.64882   -14.69738 1.000 19.32280 ? 418 PRO A CG  1 
ATOM   3365 C CD  . PRO A 1 337 ? 1.74648   2.56873   -15.85766 1.000 17.87304 ? 418 PRO A CD  1 
ATOM   3366 N N   . GLU A 1 338 ? 3.52560   3.15382   -11.79321 1.000 19.33444 ? 419 GLU A N   1 
ATOM   3367 C CA  . GLU A 1 338 ? 4.78510   2.93968   -11.08516 1.000 19.60509 ? 419 GLU A CA  1 
ATOM   3368 C C   . GLU A 1 338 ? 5.44434   1.62943   -11.51150 1.000 18.85256 ? 419 GLU A C   1 
ATOM   3369 O O   . GLU A 1 338 ? 4.77657   0.66371   -11.89356 1.000 17.52790 ? 419 GLU A O   1 
ATOM   3370 C CB  . GLU A 1 338 ? 4.54142   2.90766   -9.57637  1.000 22.07966 ? 419 GLU A CB  1 
ATOM   3371 C CG  . GLU A 1 338 ? 4.12995   4.24713   -8.97994  1.000 22.53556 ? 419 GLU A CG  1 
ATOM   3372 C CD  . GLU A 1 338 ? 5.30815   5.16190   -8.72423  1.000 26.65253 ? 419 GLU A CD  1 
ATOM   3373 O OE1 . GLU A 1 338 ? 6.45674   4.67238   -8.70486  1.000 25.67525 ? 419 GLU A OE1 1 
ATOM   3374 O OE2 . GLU A 1 338 ? 5.08415   6.37512   -8.54252  1.000 29.01484 ? 419 GLU A OE2 1 
ATOM   3375 N N   . ALA A 1 339 ? 6.77515   1.60470   -11.40974 1.000 19.81205 ? 420 ALA A N   1 
ATOM   3376 C CA  . ALA A 1 339 ? 7.56231   0.43919   -11.79712 1.000 19.57500 ? 420 ALA A CA  1 
ATOM   3377 C C   . ALA A 1 339 ? 7.02887   -0.82832  -11.14340 1.000 19.93719 ? 420 ALA A C   1 
ATOM   3378 O O   . ALA A 1 339 ? 6.74903   -0.85743  -9.94050  1.000 22.02660 ? 420 ALA A O   1 
ATOM   3379 C CB  . ALA A 1 339 ? 9.02612   0.64767   -11.40299 1.000 20.32238 ? 420 ALA A CB  1 
ATOM   3380 N N   . GLY A 1 340 ? 6.88097   -1.87672  -11.94973 1.000 17.79001 ? 421 GLY A N   1 
ATOM   3381 C CA  . GLY A 1 340 ? 6.44236   -3.16879  -11.47472 1.000 19.14819 ? 421 GLY A CA  1 
ATOM   3382 C C   . GLY A 1 340 ? 4.94362   -3.38218  -11.48005 1.000 20.00243 ? 421 GLY A C   1 
ATOM   3383 O O   . GLY A 1 340 ? 4.49465   -4.53678  -11.44138 1.000 22.35092 ? 421 GLY A O   1 
ATOM   3384 N N   . THR A 1 341 ? 4.15849   -2.31159  -11.53056 1.000 19.99955 ? 422 THR A N   1 
ATOM   3385 C CA  . THR A 1 341 ? 2.70845   -2.42312  -11.52262 1.000 20.46133 ? 422 THR A CA  1 
ATOM   3386 C C   . THR A 1 341 ? 2.16633   -2.59587  -12.94214 1.000 18.33678 ? 422 THR A C   1 
ATOM   3387 O O   . THR A 1 341 ? 2.84118   -2.31137  -13.93831 1.000 18.48939 ? 422 THR A O   1 
ATOM   3388 C CB  . THR A 1 341 ? 2.07507   -1.21336  -10.82595 1.000 19.10220 ? 422 THR A CB  1 
ATOM   3389 O OG1 . THR A 1 341 ? 2.10606   -0.07350  -11.69441 1.000 21.24704 ? 422 THR A OG1 1 
ATOM   3390 C CG2 . THR A 1 341 ? 2.82995   -0.88899  -9.54263  1.000 24.03012 ? 422 THR A CG2 1 
ATOM   3391 N N   . TRP A 1 342 ? 0.93244   -3.08274  -13.02767 1.000 19.31960 ? 423 TRP A N   1 
ATOM   3392 C CA  . TRP A 1 342 ? 0.36875   -3.44809  -14.31877 1.000 17.25329 ? 423 TRP A CA  1 
ATOM   3393 C C   . TRP A 1 342 ? 0.05306   -2.22143  -15.16846 1.000 17.40793 ? 423 TRP A C   1 
ATOM   3394 O O   . TRP A 1 342 ? -0.51957  -1.23628  -14.68839 1.000 18.92251 ? 423 TRP A O   1 
ATOM   3395 C CB  . TRP A 1 342 ? -0.89061  -4.28621  -14.13569 1.000 18.51564 ? 423 TRP A CB  1 
ATOM   3396 C CG  . TRP A 1 342 ? -1.28197  -4.97400  -15.37599 1.000 17.83519 ? 423 TRP A CG  1 
ATOM   3397 C CD1 . TRP A 1 342 ? -2.37496  -4.72176  -16.15313 1.000 17.16653 ? 423 TRP A CD1 1 
ATOM   3398 C CD2 . TRP A 1 342 ? -0.57527  -6.04353  -16.01602 1.000 16.47668 ? 423 TRP A CD2 1 
ATOM   3399 N NE1 . TRP A 1 342 ? -2.39825  -5.56862  -17.22685 1.000 16.77841 ? 423 TRP A NE1 1 
ATOM   3400 C CE2 . TRP A 1 342 ? -1.30035  -6.39140  -17.16864 1.000 15.80886 ? 423 TRP A CE2 1 
ATOM   3401 C CE3 . TRP A 1 342 ? 0.60671   -6.73760  -15.72635 1.000 16.58013 ? 423 TRP A CE3 1 
ATOM   3402 C CZ2 . TRP A 1 342 ? -0.89437  -7.41453  -18.02350 1.000 17.44398 ? 423 TRP A CZ2 1 
ATOM   3403 C CZ3 . TRP A 1 342 ? 1.00450   -7.75496  -16.57614 1.000 16.84221 ? 423 TRP A CZ3 1 
ATOM   3404 C CH2 . TRP A 1 342 ? 0.25982   -8.08185  -17.70663 1.000 16.51226 ? 423 TRP A CH2 1 
ATOM   3405 N N   . PHE A 1 343 ? 0.40402   -2.30609  -16.45193 1.000 17.16694 ? 424 PHE A N   1 
ATOM   3406 C CA  . PHE A 1 343 ? 0.23587   -1.23344  -17.43433 1.000 15.71701 ? 424 PHE A CA  1 
ATOM   3407 C C   . PHE A 1 343 ? -0.60352  -1.83178  -18.56058 1.000 15.59894 ? 424 PHE A C   1 
ATOM   3408 O O   . PHE A 1 343 ? -0.07560  -2.33858  -19.55386 1.000 14.62233 ? 424 PHE A O   1 
ATOM   3409 C CB  . PHE A 1 343 ? 1.63417   -0.80623  -17.90313 1.000 16.16249 ? 424 PHE A CB  1 
ATOM   3410 C CG  . PHE A 1 343 ? 1.67016   0.43107   -18.76145 1.000 14.91380 ? 424 PHE A CG  1 
ATOM   3411 C CD1 . PHE A 1 343 ? 0.51461   1.05430   -19.22060 1.000 15.79730 ? 424 PHE A CD1 1 
ATOM   3412 C CD2 . PHE A 1 343 ? 2.89613   0.97041   -19.10625 1.000 15.42280 ? 424 PHE A CD2 1 
ATOM   3413 C CE1 . PHE A 1 343 ? 0.60073   2.19635   -20.00849 1.000 16.80455 ? 424 PHE A CE1 1 
ATOM   3414 C CE2 . PHE A 1 343 ? 2.98626   2.10049   -19.88759 1.000 15.52644 ? 424 PHE A CE2 1 
ATOM   3415 C CZ  . PHE A 1 343 ? 1.83916   2.71745   -20.34344 1.000 16.03403 ? 424 PHE A CZ  1 
ATOM   3416 N N   . GLN A 1 344 ? -1.93023  -1.76123  -18.39511 1.000 17.98705 ? 425 GLN A N   1 
ATOM   3417 C CA  . GLN A 1 344 ? -2.83797  -2.52430  -19.24796 1.000 14.84173 ? 425 GLN A CA  1 
ATOM   3418 C C   . GLN A 1 344 ? -2.70619  -2.15366  -20.72122 1.000 14.23149 ? 425 GLN A C   1 
ATOM   3419 O O   . GLN A 1 344 ? -2.69665  -3.02865  -21.58918 1.000 16.03441 ? 425 GLN A O   1 
ATOM   3420 C CB  . GLN A 1 344 ? -4.27726  -2.31684  -18.78636 1.000 16.92611 ? 425 GLN A CB  1 
ATOM   3421 C CG  . GLN A 1 344 ? -5.30479  -2.92588  -19.72300 1.000 16.08619 ? 425 GLN A CG  1 
ATOM   3422 C CD  . GLN A 1 344 ? -5.33246  -4.43470  -19.65344 1.000 17.18064 ? 425 GLN A CD  1 
ATOM   3423 O OE1 . GLN A 1 344 ? -4.84884  -5.02618  -18.69201 1.000 19.98402 ? 425 GLN A OE1 1 
ATOM   3424 N NE2 . GLN A 1 344 ? -5.91756  -5.06432  -20.66523 1.000 19.19675 ? 425 GLN A NE2 1 
ATOM   3425 N N   . ALA A 1 345 ? -2.64735  -0.86271  -21.03119 1.000 15.29418 ? 426 ALA A N   1 
ATOM   3426 C CA  . ALA A 1 345 ? -2.57618  -0.46789  -22.43424 1.000 14.45358 ? 426 ALA A CA  1 
ATOM   3427 C C   . ALA A 1 345 ? -1.30391  -0.98728  -23.08239 1.000 15.16735 ? 426 ALA A C   1 
ATOM   3428 O O   . ALA A 1 345 ? -1.31078  -1.37928  -24.25484 1.000 15.49891 ? 426 ALA A O   1 
ATOM   3429 C CB  . ALA A 1 345 ? -2.64693  1.05382   -22.56721 1.000 16.39610 ? 426 ALA A CB  1 
ATOM   3430 N N   . TYR A 1 346 ? -0.19526  -0.97130  -22.33306 1.000 15.01478 ? 427 TYR A N   1 
ATOM   3431 C CA  . TYR A 1 346 ? 1.07425   -1.48458  -22.84025 1.000 13.43367 ? 427 TYR A CA  1 
ATOM   3432 C C   . TYR A 1 346 ? 0.99519   -2.98103  -23.11355 1.000 12.98771 ? 427 TYR A C   1 
ATOM   3433 O O   . TYR A 1 346 ? 1.49359   -3.46042  -24.13891 1.000 13.23778 ? 427 TYR A O   1 
ATOM   3434 C CB  . TYR A 1 346 ? 2.18063   -1.17203  -21.83163 1.000 13.32975 ? 427 TYR A CB  1 
ATOM   3435 C CG  . TYR A 1 346 ? 3.56613   -1.24428  -22.42100 1.000 12.88706 ? 427 TYR A CG  1 
ATOM   3436 C CD1 . TYR A 1 346 ? 4.27013   -2.44086  -22.43424 1.000 12.46797 ? 427 TYR A CD1 1 
ATOM   3437 C CD2 . TYR A 1 346 ? 4.17052   -0.11712  -22.97191 1.000 11.75546 ? 427 TYR A CD2 1 
ATOM   3438 C CE1 . TYR A 1 346 ? 5.53897   -2.50804  -22.97746 1.000 11.96114 ? 427 TYR A CE1 1 
ATOM   3439 C CE2 . TYR A 1 346 ? 5.43897   -0.17772  -23.52044 1.000 12.53125 ? 427 TYR A CE2 1 
ATOM   3440 C CZ  . TYR A 1 346 ? 6.11008   -1.37794  -23.51637 1.000 11.61468 ? 427 TYR A CZ  1 
ATOM   3441 O OH  . TYR A 1 346 ? 7.37082   -1.47697  -24.06456 1.000 12.47431 ? 427 TYR A OH  1 
ATOM   3442 N N   . PHE A 1 347 ? 0.37021   -3.73112  -22.20524 1.000 14.89006 ? 428 PHE A N   1 
ATOM   3443 C CA  . PHE A 1 347 ? 0.16865   -5.15549  -22.42652 1.000 13.42637 ? 428 PHE A CA  1 
ATOM   3444 C C   . PHE A 1 347 ? -0.64030  -5.40537  -23.69184 1.000 13.46905 ? 428 PHE A C   1 
ATOM   3445 O O   . PHE A 1 347 ? -0.31107  -6.29020  -24.48536 1.000 14.87566 ? 428 PHE A O   1 
ATOM   3446 C CB  . PHE A 1 347 ? -0.52105  -5.78263  -21.21687 1.000 14.10639 ? 428 PHE A CB  1 
ATOM   3447 C CG  . PHE A 1 347 ? -0.90936  -7.21324  -21.42736 1.000 13.77386 ? 428 PHE A CG  1 
ATOM   3448 C CD1 . PHE A 1 347 ? 0.03831   -8.22552  -21.36410 1.000 16.39497 ? 428 PHE A CD1 1 
ATOM   3449 C CD2 . PHE A 1 347 ? -2.23102  -7.55155  -21.68769 1.000 16.30179 ? 428 PHE A CD2 1 
ATOM   3450 C CE1 . PHE A 1 347 ? -0.32176  -9.54393  -21.55404 1.000 17.08806 ? 428 PHE A CE1 1 
ATOM   3451 C CE2 . PHE A 1 347 ? -2.59769  -8.86061  -21.88379 1.000 17.88691 ? 428 PHE A CE2 1 
ATOM   3452 C CZ  . PHE A 1 347 ? -1.64265  -9.86042  -21.81660 1.000 17.07028 ? 428 PHE A CZ  1 
ATOM   3453 N N   A GLN A 1 348 ? -1.74220  -4.67814  -23.87064 0.691 16.06233 ? 429 GLN A N   1 
ATOM   3454 N N   B GLN A 1 348 ? -1.67616  -4.58984  -23.92415 0.309 16.02082 ? 429 GLN A N   1 
ATOM   3455 C CA  A GLN A 1 348 ? -2.56325  -4.93890  -25.04489 0.691 16.59963 ? 429 GLN A CA  1 
ATOM   3456 C CA  B GLN A 1 348 ? -2.49266  -4.74473  -25.12601 0.309 16.85054 ? 429 GLN A CA  1 
ATOM   3457 C C   A GLN A 1 348 ? -1.76920  -4.75191  -26.33053 0.691 15.24508 ? 429 GLN A C   1 
ATOM   3458 C C   B GLN A 1 348 ? -1.66781  -4.55738  -26.39539 0.309 15.31401 ? 429 GLN A C   1 
ATOM   3459 O O   A GLN A 1 348 ? -1.90465  -5.53942  -27.27222 0.691 15.35250 ? 429 GLN A O   1 
ATOM   3460 O O   B GLN A 1 348 ? -1.82873  -5.30917  -27.36235 0.309 14.43430 ? 429 GLN A O   1 
ATOM   3461 C CB  A GLN A 1 348 ? -3.80737  -4.06463  -25.03323 0.691 18.28514 ? 429 GLN A CB  1 
ATOM   3462 C CB  B GLN A 1 348 ? -3.65794  -3.75621  -25.10415 0.309 19.55917 ? 429 GLN A CB  1 
ATOM   3463 C CG  A GLN A 1 348 ? -4.78978  -4.45795  -26.09032 0.691 17.77953 ? 429 GLN A CG  1 
ATOM   3464 C CG  B GLN A 1 348 ? -4.52671  -3.83575  -23.86749 0.309 22.10703 ? 429 GLN A CG  1 
ATOM   3465 C CD  A GLN A 1 348 ? -6.05803  -3.66691  -25.99357 0.691 15.56750 ? 429 GLN A CD  1 
ATOM   3466 C CD  B GLN A 1 348 ? -5.83915  -3.10352  -24.03516 0.309 19.82618 ? 429 GLN A CD  1 
ATOM   3467 O OE1 A GLN A 1 348 ? -6.75848  -3.73603  -24.99064 0.691 17.58578 ? 429 GLN A OE1 1 
ATOM   3468 O OE1 B GLN A 1 348 ? -6.78689  -3.31447  -23.27609 0.309 15.69710 ? 429 GLN A OE1 1 
ATOM   3469 N NE2 A GLN A 1 348 ? -6.36176  -2.89977  -27.03021 0.691 23.14898 ? 429 GLN A NE2 1 
ATOM   3470 N NE2 B GLN A 1 348 ? -5.90318  -2.23297  -25.03698 0.309 21.93272 ? 429 GLN A NE2 1 
ATOM   3471 N N   A THR A 1 349 ? -0.90342  -3.74016  -26.37305 0.691 14.71942 ? 430 THR A N   1 
ATOM   3472 N N   B THR A 1 349 ? -0.78541  -3.55504  -26.42073 0.309 14.00122 ? 430 THR A N   1 
ATOM   3473 C CA  A THR A 1 349 ? -0.07288  -3.54506  -27.55509 0.691 13.15358 ? 430 THR A CA  1 
ATOM   3474 C CA  B THR A 1 349 ? 0.07012   -3.37723  -27.59087 0.309 13.24293 ? 430 THR A CA  1 
ATOM   3475 C C   A THR A 1 349 ? 0.98784   -4.63117  -27.69016 0.691 12.37784 ? 430 THR A C   1 
ATOM   3476 C C   B THR A 1 349 ? 1.06038   -4.52680  -27.73068 0.309 12.59674 ? 430 THR A C   1 
ATOM   3477 O O   A THR A 1 349 ? 1.27231   -5.08034  -28.80452 0.691 13.94362 ? 430 THR A O   1 
ATOM   3478 O O   B THR A 1 349 ? 1.35455   -4.96508  -28.84780 0.309 13.97239 ? 430 THR A O   1 
ATOM   3479 C CB  A THR A 1 349 ? 0.54205   -2.15416  -27.52609 0.691 13.99322 ? 430 THR A CB  1 
ATOM   3480 C CB  B THR A 1 349 ? 0.80191   -2.03662  -27.52416 0.309 14.06404 ? 430 THR A CB  1 
ATOM   3481 O OG1 A THR A 1 349 ? -0.52111  -1.19842  -27.56982 0.691 14.58650 ? 430 THR A OG1 1 
ATOM   3482 O OG1 B THR A 1 349 ? 1.37360   -1.86458  -26.22235 0.309 23.11792 ? 430 THR A OG1 1 
ATOM   3483 C CG2 A THR A 1 349 ? 1.47047   -1.93588  -28.70593 0.691 13.36662 ? 430 THR A CG2 1 
ATOM   3484 C CG2 B THR A 1 349 ? -0.15414  -0.89491  -27.80785 0.309 17.10929 ? 430 THR A CG2 1 
ATOM   3485 N N   A LEU A 1 350 ? 1.59584   -5.05908  -26.57375 0.691 11.60218 ? 431 LEU A N   1 
ATOM   3486 N N   B LEU A 1 350 ? 1.58616   -5.02308  -26.60577 0.309 11.74703 ? 431 LEU A N   1 
ATOM   3487 C CA  A LEU A 1 350 ? 2.52883   -6.18385  -26.63407 0.691 12.27711 ? 431 LEU A CA  1 
ATOM   3488 C CA  B LEU A 1 350 ? 2.50710   -6.15552  -26.64267 0.309 12.35639 ? 431 LEU A CA  1 
ATOM   3489 C C   A LEU A 1 350 ? 1.86786   -7.39222  -27.28251 0.691 12.43531 ? 431 LEU A C   1 
ATOM   3490 C C   B LEU A 1 350 ? 1.85525   -7.36581  -27.29884 0.309 12.45355 ? 431 LEU A C   1 
ATOM   3491 O O   A LEU A 1 350 ? 2.50132   -8.11539  -28.06174 0.691 12.74207 ? 431 LEU A O   1 
ATOM   3492 O O   B LEU A 1 350 ? 2.48878   -8.06971  -28.09496 0.309 12.71733 ? 431 LEU A O   1 
ATOM   3493 C CB  A LEU A 1 350 ? 3.02767   -6.55476  -25.23420 0.691 12.87124 ? 431 LEU A CB  1 
ATOM   3494 C CB  B LEU A 1 350 ? 2.92971   -6.50506  -25.21755 0.309 13.02343 ? 431 LEU A CB  1 
ATOM   3495 C CG  A LEU A 1 350 ? 4.07482   -5.65708  -24.57301 0.691 11.88864 ? 431 LEU A CG  1 
ATOM   3496 C CG  B LEU A 1 350 ? 4.12779   -5.76233  -24.63433 0.309 11.83647 ? 431 LEU A CG  1 
ATOM   3497 C CD1 A LEU A 1 350 ? 4.14857   -5.96309  -23.09063 0.691 11.40794 ? 431 LEU A CD1 1 
ATOM   3498 C CD1 B LEU A 1 350 ? 4.34944   -6.23880  -23.22841 0.309 11.58796 ? 431 LEU A CD1 1 
ATOM   3499 C CD2 A LEU A 1 350 ? 5.43808   -5.81991  -25.23455 0.691 12.36782 ? 431 LEU A CD2 1 
ATOM   3500 C CD2 B LEU A 1 350 ? 5.37606   -5.97791  -25.46706 0.309 12.64619 ? 431 LEU A CD2 1 
ATOM   3501 N N   . VAL A 1 351 ? 0.58782   -7.62533  -26.96655 1.000 13.39868 ? 432 VAL A N   1 
ATOM   3502 C CA  . VAL A 1 351 ? -0.14044  -8.73895  -27.56452 1.000 13.13086 ? 432 VAL A CA  1 
ATOM   3503 C C   . VAL A 1 351 ? -0.39000  -8.47759  -29.04408 1.000 13.18312 ? 432 VAL A C   1 
ATOM   3504 O O   . VAL A 1 351 ? -0.11670  -9.32801  -29.89332 1.000 14.18138 ? 432 VAL A O   1 
ATOM   3505 C CB  . VAL A 1 351 ? -1.45806  -9.01058  -26.80856 1.000 15.85379 ? 432 VAL A CB  1 
ATOM   3506 C CG1 . VAL A 1 351 ? -2.24351  -10.12666 -27.50133 1.000 18.53827 ? 432 VAL A CG1 1 
ATOM   3507 C CG2 . VAL A 1 351 ? -1.20862  -9.36892  -25.36236 1.000 15.82782 ? 432 VAL A CG2 1 
ATOM   3508 N N   . SER A 1 352 ? -0.90842  -7.29030  -29.37398 1.000 13.88115 ? 433 SER A N   1 
ATOM   3509 C CA  A SER A 1 352 ? -1.24523  -6.99444  -30.76179 0.593 15.79309 ? 433 SER A CA  1 
ATOM   3510 C CA  B SER A 1 352 ? -1.24409  -6.99259  -30.76408 0.407 15.78260 ? 433 SER A CA  1 
ATOM   3511 C C   . SER A 1 352 ? -0.00810  -7.01452  -31.65183 1.000 14.98110 ? 433 SER A C   1 
ATOM   3512 O O   . SER A 1 352 ? -0.06850  -7.44533  -32.80770 1.000 17.44470 ? 433 SER A O   1 
ATOM   3513 C CB  A SER A 1 352 ? -1.94174  -5.63692  -30.84462 0.593 17.29349 ? 433 SER A CB  1 
ATOM   3514 C CB  B SER A 1 352 ? -1.91446  -5.62508  -30.85583 0.407 17.25806 ? 433 SER A CB  1 
ATOM   3515 O OG  A SER A 1 352 ? -2.43296  -5.41013  -32.14640 0.593 20.00234 ? 433 SER A OG  1 
ATOM   3516 O OG  B SER A 1 352 ? -3.16636  -5.64650  -30.21377 0.407 17.05566 ? 433 SER A OG  1 
ATOM   3517 N N   . ALA A 1 353 ? 1.12338   -6.55803  -31.13029 1.000 13.74203 ? 434 ALA A N   1 
ATOM   3518 C CA  . ALA A 1 353 ? 2.34437   -6.43012  -31.90827 1.000 13.61373 ? 434 ALA A CA  1 
ATOM   3519 C C   . ALA A 1 353 ? 3.27591   -7.62646  -31.77522 1.000 13.19170 ? 434 ALA A C   1 
ATOM   3520 O O   . ALA A 1 353 ? 4.41567   -7.55930  -32.24728 1.000 15.38258 ? 434 ALA A O   1 
ATOM   3521 C CB  . ALA A 1 353 ? 3.07490   -5.14714  -31.50857 1.000 14.13935 ? 434 ALA A CB  1 
ATOM   3522 N N   . ALA A 1 354 ? 2.82264   -8.71112  -31.15233 1.000 13.24091 ? 435 ALA A N   1 
ATOM   3523 C CA  . ALA A 1 354 ? 3.68464   -9.86487  -30.92314 1.000 13.57447 ? 435 ALA A CA  1 
ATOM   3524 C C   . ALA A 1 354 ? 4.28471   -10.36749 -32.23243 1.000 13.81765 ? 435 ALA A C   1 
ATOM   3525 O O   . ALA A 1 354 ? 3.60707   -10.44838 -33.26598 1.000 15.98846 ? 435 ALA A O   1 
ATOM   3526 C CB  . ALA A 1 354 ? 2.88254   -10.98498 -30.25992 1.000 16.06742 ? 435 ALA A CB  1 
ATOM   3527 N N   . ASN A 1 355 ? 5.56598   -10.70802 -32.19083 1.000 14.47151 ? 436 ASN A N   1 
ATOM   3528 C CA  . ASN A 1 355 ? 6.23338   -11.25255 -33.35915 1.000 15.03722 ? 436 ASN A CA  1 
ATOM   3529 C C   . ASN A 1 355 ? 7.26994   -12.25788 -32.88186 1.000 15.06498 ? 436 ASN A C   1 
ATOM   3530 O O   . ASN A 1 355 ? 8.25018   -11.86505 -32.23026 1.000 15.84175 ? 436 ASN A O   1 
ATOM   3531 C CB  . ASN A 1 355 ? 6.88893   -10.13392 -34.16360 1.000 16.95262 ? 436 ASN A CB  1 
ATOM   3532 C CG  . ASN A 1 355 ? 7.75971   -10.65246 -35.27236 1.000 21.67232 ? 436 ASN A CG  1 
ATOM   3533 O OD1 . ASN A 1 355 ? 7.48881   -11.70461 -35.85678 1.000 21.31520 ? 436 ASN A OD1 1 
ATOM   3534 N ND2 . ASN A 1 355 ? 8.84025   -9.93105  -35.55374 1.000 22.57797 ? 436 ASN A ND2 1 
ATOM   3535 N N   . PRO A 1 356 ? 7.10133   -13.55886 -33.17197 1.000 17.81661 ? 437 PRO A N   1 
ATOM   3536 C CA  . PRO A 1 356 ? 6.01698   -14.17563 -33.95273 1.000 18.09584 ? 437 PRO A CA  1 
ATOM   3537 C C   . PRO A 1 356 ? 4.64355   -13.93984 -33.34053 1.000 17.24803 ? 437 PRO A C   1 
ATOM   3538 O O   . PRO A 1 356 ? 4.53348   -13.73051 -32.13823 1.000 17.49675 ? 437 PRO A O   1 
ATOM   3539 C CB  . PRO A 1 356 ? 6.35089   -15.67316 -33.88894 1.000 22.59745 ? 437 PRO A CB  1 
ATOM   3540 C CG  . PRO A 1 356 ? 7.80227   -15.73572 -33.58401 1.000 22.16257 ? 437 PRO A CG  1 
ATOM   3541 C CD  . PRO A 1 356 ? 8.06497   -14.56559 -32.69144 1.000 18.48922 ? 437 PRO A CD  1 
ATOM   3542 N N   . PRO A 1 357 ? 3.59393   -13.95900 -34.16071 1.000 23.52734 ? 438 PRO A N   1 
ATOM   3543 C CA  . PRO A 1 357 ? 2.25438   -13.71698 -33.61605 1.000 19.41743 ? 438 PRO A CA  1 
ATOM   3544 C C   . PRO A 1 357 ? 1.88010   -14.78724 -32.60374 1.000 20.55578 ? 438 PRO A C   1 
ATOM   3545 O O   . PRO A 1 357 ? 2.34098   -15.92795 -32.66974 1.000 24.26849 ? 438 PRO A O   1 
ATOM   3546 C CB  . PRO A 1 357 ? 1.33100   -13.76270 -34.84357 1.000 23.97426 ? 438 PRO A CB  1 
ATOM   3547 C CG  . PRO A 1 357 ? 2.17095   -14.09811 -36.00836 1.000 33.17487 ? 438 PRO A CG  1 
ATOM   3548 C CD  . PRO A 1 357 ? 3.59049   -14.28880 -35.59686 1.000 27.84026 ? 438 PRO A CD  1 
ATOM   3549 N N   . LEU A 1 358 ? 1.05857   -14.39380 -31.64423 1.000 20.94746 ? 439 LEU A N   1 
ATOM   3550 C CA  . LEU A 1 358 ? 0.57326   -15.32706 -30.63868 1.000 24.85598 ? 439 LEU A CA  1 
ATOM   3551 C C   . LEU A 1 358 ? -0.45815  -16.26502 -31.25224 1.000 35.06838 ? 439 LEU A C   1 
ATOM   3552 O O   . LEU A 1 358 ? -0.73153  -17.34632 -30.72637 1.000 37.09783 ? 439 LEU A O   1 
ATOM   3553 C CB  . LEU A 1 358 ? -0.03327  -14.56441 -29.46804 1.000 22.93623 ? 439 LEU A CB  1 
ATOM   3554 C CG  . LEU A 1 358 ? 1.00432   -13.85931 -28.59387 1.000 20.47938 ? 439 LEU A CG  1 
ATOM   3555 C CD1 . LEU A 1 358 ? 0.33691   -12.78301 -27.75708 1.000 21.99550 ? 439 LEU A CD1 1 
ATOM   3556 C CD2 . LEU A 1 358 ? 1.74541   -14.86288 -27.70880 1.000 24.25594 ? 439 LEU A CD2 1 
ATOM   3557 O OXT . LEU A 1 358 ? -1.03786  -15.95475 -32.29361 1.000 34.52942 ? 439 LEU A OXT 1 
HETATM 3558 O O   . HOH B 2 .   ? 16.21612  -26.80135 4.63083   1.000 34.72299 ? 501 HOH A O   1 
HETATM 3559 O O   . HOH B 2 .   ? 6.12977   -13.94058 -10.98461 1.000 19.40814 ? 502 HOH A O   1 
HETATM 3560 O O   . HOH B 2 .   ? 15.00437  -4.24353  -40.78870 1.000 36.33645 ? 503 HOH A O   1 
HETATM 3561 O O   . HOH B 2 .   ? 39.87643  -13.45518 -5.13772  1.000 19.26982 ? 504 HOH A O   1 
HETATM 3562 O O   . HOH B 2 .   ? -9.28034  -14.03431 -18.56754 1.000 32.60749 ? 505 HOH A O   1 
HETATM 3563 O O   . HOH B 2 .   ? 34.956    9.851     -12.181   1.000 21.09619 ? 506 HOH A O   1 
HETATM 3564 O O   A HOH B 2 .   ? 17.94779  0.64620   -3.16797  0.565 21.20698 ? 507 HOH A O   1 
HETATM 3565 O O   B HOH B 2 .   ? 18.00857  2.14666   -2.59913  0.435 18.34324 ? 507 HOH A O   1 
HETATM 3566 O O   A HOH B 2 .   ? 23.88253  -27.58773 -24.25932 0.670 12.06720 ? 508 HOH A O   1 
HETATM 3567 O O   B HOH B 2 .   ? 24.20661  -26.72983 -24.09397 0.330 12.74106 ? 508 HOH A O   1 
HETATM 3568 O O   . HOH B 2 .   ? -9.31175  -3.65658  -25.73998 1.000 23.37725 ? 509 HOH A O   1 
HETATM 3569 O O   . HOH B 2 .   ? 14.12725  6.15172   -10.54192 1.000 22.86761 ? 510 HOH A O   1 
HETATM 3570 O O   . HOH B 2 .   ? -13.20030 -9.55240  -24.09747 1.000 34.63750 ? 511 HOH A O   1 
HETATM 3571 O O   . HOH B 2 .   ? 12.13861  7.07621   -4.21903  1.000 32.54440 ? 512 HOH A O   1 
HETATM 3572 O O   . HOH B 2 .   ? 35.482    7.410     -13.783   1.000 30.54012 ? 513 HOH A O   1 
HETATM 3573 O O   . HOH B 2 .   ? 10.73917  4.41147   -10.90848 1.000 23.70869 ? 514 HOH A O   1 
HETATM 3574 O O   A HOH B 2 .   ? 2.38189   -6.13625  -10.58014 0.562 23.20126 ? 515 HOH A O   1 
HETATM 3575 O O   B HOH B 2 .   ? 3.76569   -6.15319  -10.03024 0.438 21.11241 ? 515 HOH A O   1 
HETATM 3576 O O   . HOH B 2 .   ? 8.98876   -34.66036 -9.38817  1.000 22.86726 ? 516 HOH A O   1 
HETATM 3577 O O   . HOH B 2 .   ? 19.74138  -21.87789 4.91183   1.000 29.06850 ? 517 HOH A O   1 
HETATM 3578 O O   . HOH B 2 .   ? 24.573    9.239     -38.265   1.000 15.96641 ? 518 HOH A O   1 
HETATM 3579 O O   . HOH B 2 .   ? 7.61165   -4.75471  -5.08577  1.000 31.39170 ? 519 HOH A O   1 
HETATM 3580 O O   . HOH B 2 .   ? 18.70477  -17.03743 -32.90999 1.000 30.73063 ? 520 HOH A O   1 
HETATM 3581 O O   . HOH B 2 .   ? 41.21113  -12.27381 -7.32443  1.000 30.16508 ? 521 HOH A O   1 
HETATM 3582 O O   . HOH B 2 .   ? 30.73590  -24.97302 -19.65234 1.000 31.79321 ? 522 HOH A O   1 
HETATM 3583 O O   . HOH B 2 .   ? 31.37803  -8.27634  -33.99421 1.000 29.03540 ? 523 HOH A O   1 
HETATM 3584 O O   . HOH B 2 .   ? 17.01692  -1.50381  -39.66058 1.000 18.27821 ? 524 HOH A O   1 
HETATM 3585 O O   . HOH B 2 .   ? 40.73721  -16.40000 -14.49806 1.000 33.01176 ? 525 HOH A O   1 
HETATM 3586 O O   . HOH B 2 .   ? 1.71644   -22.06094 -11.96640 1.000 24.68868 ? 526 HOH A O   1 
HETATM 3587 O O   . HOH B 2 .   ? 3.85296   -2.17276  -26.10911 1.000 14.56114 ? 527 HOH A O   1 
HETATM 3588 O O   . HOH B 2 .   ? 20.42475  -4.47427  -9.19082  1.000 12.55403 ? 528 HOH A O   1 
HETATM 3589 O O   A HOH B 2 .   ? 16.56724  -26.57278 -5.25945  0.723 17.66301 ? 529 HOH A O   1 
HETATM 3590 O O   B HOH B 2 .   ? 14.63847  -25.43155 -4.27318  0.277 11.99635 ? 529 HOH A O   1 
HETATM 3591 O O   . HOH B 2 .   ? -0.663    -37.915   -10.263   1.000 24.92006 ? 530 HOH A O   1 
HETATM 3592 O O   . HOH B 2 .   ? 23.21720  -9.81172  7.44385   1.000 28.26729 ? 531 HOH A O   1 
HETATM 3593 O O   . HOH B 2 .   ? 20.54694  -29.88341 -23.77976 1.000 16.03825 ? 532 HOH A O   1 
HETATM 3594 O O   A HOH B 2 .   ? 19.58103  -1.21379  8.80159   0.562 17.68131 ? 533 HOH A O   1 
HETATM 3595 O O   B HOH B 2 .   ? 17.72205  0.49584   7.93301   0.438 16.75297 ? 533 HOH A O   1 
HETATM 3596 O O   . HOH B 2 .   ? 30.33524  -21.47888 -23.82227 1.000 23.38133 ? 534 HOH A O   1 
HETATM 3597 O O   . HOH B 2 .   ? 43.19351  -17.95904 -18.15978 1.000 33.15226 ? 535 HOH A O   1 
HETATM 3598 O O   B HOH B 2 .   ? 6.00741   -38.67635 -9.01915  0.585 25.41874 ? 536 HOH A O   1 
HETATM 3599 O O   C HOH B 2 .   ? 8.01507   -37.36572 -9.10813  0.415 19.15872 ? 536 HOH A O   1 
HETATM 3600 O O   . HOH B 2 .   ? 19.80529  9.96957   -31.47652 1.000 18.30683 ? 537 HOH A O   1 
HETATM 3601 O O   . HOH B 2 .   ? 10.35384  -30.22115 1.62427   1.000 22.13702 ? 538 HOH A O   1 
HETATM 3602 O O   . HOH B 2 .   ? -5.77403  -5.32028  -15.73008 1.000 31.85951 ? 539 HOH A O   1 
HETATM 3603 O O   . HOH B 2 .   ? 10.798    -13.764   4.173     1.000 17.29130 ? 540 HOH A O   1 
HETATM 3604 O O   . HOH B 2 .   ? 40.08657  -13.04584 -21.05993 1.000 30.78248 ? 541 HOH A O   1 
HETATM 3605 O O   . HOH B 2 .   ? 19.54322  5.64740   -8.22604  1.000 30.22300 ? 542 HOH A O   1 
HETATM 3606 O O   A HOH B 2 .   ? 39.52165  -11.77572 -17.32707 0.577 21.76657 ? 543 HOH A O   1 
HETATM 3607 O O   B HOH B 2 .   ? 39.28141  -11.04540 -18.26367 0.423 17.90505 ? 543 HOH A O   1 
HETATM 3608 O O   . HOH B 2 .   ? 8.75109   -32.47625 -7.76558  1.000 15.03701 ? 544 HOH A O   1 
HETATM 3609 O O   . HOH B 2 .   ? 11.24279  -2.52804  3.25270   1.000 28.13052 ? 545 HOH A O   1 
HETATM 3610 O O   . HOH B 2 .   ? 5.11322   13.21387  -17.66939 1.000 37.61275 ? 546 HOH A O   1 
HETATM 3611 O O   . HOH B 2 .   ? 20.59296  -7.50349  -19.27742 1.000 11.46214 ? 547 HOH A O   1 
HETATM 3612 O O   . HOH B 2 .   ? 29.848    -10.468   2.212     1.000 14.05539 ? 548 HOH A O   1 
HETATM 3613 O O   A HOH B 2 .   ? 1.41667   -14.93685 -6.76095  0.648 26.81755 ? 549 HOH A O   1 
HETATM 3614 O O   B HOH B 2 .   ? 0.57539   -16.42410 -5.41427  0.352 21.51102 ? 549 HOH A O   1 
HETATM 3615 O O   . HOH B 2 .   ? 20.827    -30.965   -15.758   1.000 13.59534 ? 550 HOH A O   1 
HETATM 3616 O O   . HOH B 2 .   ? 32.06550  -4.38475  2.00703   1.000 15.69047 ? 551 HOH A O   1 
HETATM 3617 O O   . HOH B 2 .   ? 8.28243   -5.79636  -13.68076 1.000 20.55885 ? 552 HOH A O   1 
HETATM 3618 O O   . HOH B 2 .   ? 12.50166  -0.23069  -14.17020 1.000 26.24505 ? 553 HOH A O   1 
HETATM 3619 O O   . HOH B 2 .   ? 36.83520  -21.91089 -20.92850 1.000 21.13191 ? 554 HOH A O   1 
HETATM 3620 O O   . HOH B 2 .   ? 38.70172  -18.44841 -7.56658  1.000 21.15398 ? 555 HOH A O   1 
HETATM 3621 O O   . HOH B 2 .   ? 33.74762  8.70104   -10.19974 1.000 24.76824 ? 556 HOH A O   1 
HETATM 3622 O O   . HOH B 2 .   ? -0.39218  -18.29312 -28.10260 1.000 27.11624 ? 557 HOH A O   1 
HETATM 3623 O O   . HOH B 2 .   ? 34.90315  6.46488   -10.28348 1.000 32.52252 ? 558 HOH A O   1 
HETATM 3624 O O   . HOH B 2 .   ? 40.77005  -11.31732 -12.01229 1.000 33.30119 ? 559 HOH A O   1 
HETATM 3625 O O   . HOH B 2 .   ? -1.44016  8.60166   -24.14946 1.000 24.72578 ? 560 HOH A O   1 
HETATM 3626 O O   . HOH B 2 .   ? 10.31882  -30.76659 -9.35551  1.000 14.86557 ? 561 HOH A O   1 
HETATM 3627 O O   . HOH B 2 .   ? 7.32838   -5.40909  -2.18464  1.000 31.57662 ? 562 HOH A O   1 
HETATM 3628 O O   . HOH B 2 .   ? 6.722     -19.066   1.662     1.000 12.53002 ? 563 HOH A O   1 
HETATM 3629 O O   . HOH B 2 .   ? 26.91131  -18.03666 -31.77279 1.000 17.43843 ? 564 HOH A O   1 
HETATM 3630 O O   . HOH B 2 .   ? -13.82806 -6.84497  -31.83999 1.000 32.24418 ? 565 HOH A O   1 
HETATM 3631 O O   . HOH B 2 .   ? 22.00292  -29.87234 -10.71959 1.000 12.88264 ? 566 HOH A O   1 
HETATM 3632 O O   . HOH B 2 .   ? 21.492    10.002    -12.176   1.000 30.33254 ? 567 HOH A O   1 
HETATM 3633 O O   . HOH B 2 .   ? 16.50929  -28.44164 -24.23827 1.000 19.28588 ? 568 HOH A O   1 
HETATM 3634 O O   . HOH B 2 .   ? 31.81768  -12.34530 -6.65224  1.000 12.58449 ? 569 HOH A O   1 
HETATM 3635 O O   . HOH B 2 .   ? 8.95574   -26.57840 4.70625   1.000 20.00843 ? 570 HOH A O   1 
HETATM 3636 O O   . HOH B 2 .   ? 17.06477  2.17568   3.00976   1.000 29.40958 ? 571 HOH A O   1 
HETATM 3637 O O   . HOH B 2 .   ? 30.04386  0.76191   -1.78561  1.000 13.73479 ? 572 HOH A O   1 
HETATM 3638 O O   A HOH B 2 .   ? 18.17555  0.85461   -23.59818 0.609 12.23335 ? 573 HOH A O   1 
HETATM 3639 O O   B HOH B 2 .   ? 17.17276  0.80873   -24.28075 0.391 13.11153 ? 573 HOH A O   1 
HETATM 3640 O O   . HOH B 2 .   ? 15.13795  12.57701  -19.65045 1.000 32.73826 ? 574 HOH A O   1 
HETATM 3641 O O   . HOH B 2 .   ? 19.18529  -0.48335  4.00935   1.000 15.89891 ? 575 HOH A O   1 
HETATM 3642 O O   A HOH B 2 .   ? 38.60897  -1.95320  -24.52487 0.758 14.09744 ? 576 HOH A O   1 
HETATM 3643 O O   B HOH B 2 .   ? 38.62874  -0.69006  -23.07916 0.242 12.38434 ? 576 HOH A O   1 
HETATM 3644 O O   . HOH B 2 .   ? 32.91268  -16.03480 -31.05021 1.000 19.41121 ? 577 HOH A O   1 
HETATM 3645 O O   . HOH B 2 .   ? 9.06269   -38.58723 -16.02308 1.000 29.26180 ? 578 HOH A O   1 
HETATM 3646 O O   . HOH B 2 .   ? 13.81840  -1.38538  -19.20544 1.000 14.67725 ? 579 HOH A O   1 
HETATM 3647 O O   . HOH B 2 .   ? -0.58960  -6.64325  -10.76310 1.000 34.45800 ? 580 HOH A O   1 
HETATM 3648 O O   . HOH B 2 .   ? -1.07291  4.51196   -17.08177 1.000 24.88121 ? 581 HOH A O   1 
HETATM 3649 O O   . HOH B 2 .   ? 33.79991  -0.23751  0.84042   1.000 28.23496 ? 582 HOH A O   1 
HETATM 3650 O O   . HOH B 2 .   ? 28.841    6.901     -18.120   1.000 19.59409 ? 583 HOH A O   1 
HETATM 3651 O O   . HOH B 2 .   ? 12.73245  -26.41784 -19.39668 1.000 20.05485 ? 584 HOH A O   1 
HETATM 3652 O O   . HOH B 2 .   ? 24.11424  -25.73766 -22.23399 1.000 19.65020 ? 585 HOH A O   1 
HETATM 3653 O O   . HOH B 2 .   ? 9.69735   -23.33776 -26.40538 1.000 32.43600 ? 586 HOH A O   1 
HETATM 3654 O O   . HOH B 2 .   ? 1.06063   -19.22845 -25.50721 1.000 29.42634 ? 587 HOH A O   1 
HETATM 3655 O O   A HOH B 2 .   ? 13.77790  -30.98568 -22.31840 0.583 21.23776 ? 588 HOH A O   1 
HETATM 3656 O O   B HOH B 2 .   ? 13.90926  -27.53976 -23.18102 0.417 23.97233 ? 588 HOH A O   1 
HETATM 3657 O O   . HOH B 2 .   ? 21.53978  -1.99741  -9.07563  1.000 14.00249 ? 589 HOH A O   1 
HETATM 3658 O O   A HOH B 2 .   ? 26.97941  -23.63030 -19.07822 0.550 13.55566 ? 590 HOH A O   1 
HETATM 3659 O O   B HOH B 2 .   ? 29.13366  -22.33322 -18.24348 0.450 12.37027 ? 590 HOH A O   1 
HETATM 3660 O O   . HOH B 2 .   ? 20.07306  -0.59551  -41.00973 1.000 30.56131 ? 591 HOH A O   1 
HETATM 3661 O O   A HOH B 2 .   ? 28.55906  -1.67785  1.97160   0.680 12.18119 ? 592 HOH A O   1 
HETATM 3662 O O   B HOH B 2 .   ? 27.57113  -7.33024  5.16078   0.320 13.93172 ? 592 HOH A O   1 
HETATM 3663 O O   . HOH B 2 .   ? 5.70073   -1.23042  -19.85537 1.000 15.22520 ? 593 HOH A O   1 
HETATM 3664 O O   . HOH B 2 .   ? 4.33863   -1.90191  -32.74453 1.000 16.47717 ? 594 HOH A O   1 
HETATM 3665 O O   . HOH B 2 .   ? 36.62079  -3.64572  -15.66900 1.000 23.14115 ? 595 HOH A O   1 
HETATM 3666 O O   . HOH B 2 .   ? 26.10768  5.04310   -3.67384  1.000 19.59952 ? 596 HOH A O   1 
HETATM 3667 O O   . HOH B 2 .   ? 23.02544  -10.77789 -36.73767 1.000 23.08414 ? 597 HOH A O   1 
HETATM 3668 O O   . HOH B 2 .   ? 14.808    -35.005   -17.023   1.000 19.45534 ? 598 HOH A O   1 
HETATM 3669 O O   . HOH B 2 .   ? 42.070    -20.473   -23.924   1.000 22.68691 ? 599 HOH A O   1 
HETATM 3670 O O   . HOH B 2 .   ? 11.74822  -16.05577 -33.43129 1.000 19.88759 ? 600 HOH A O   1 
HETATM 3671 O O   . HOH B 2 .   ? 4.75917   -6.62060  -34.74410 1.000 24.68142 ? 601 HOH A O   1 
HETATM 3672 O O   A HOH B 2 .   ? 5.77975   -2.52885  -8.06697  0.541 22.35521 ? 602 HOH A O   1 
HETATM 3673 O O   B HOH B 2 .   ? 3.66420   -4.30690  -7.98123  0.459 26.63567 ? 602 HOH A O   1 
HETATM 3674 O O   A HOH B 2 .   ? 8.34000   3.80982   -30.46044 0.605 15.38967 ? 603 HOH A O   1 
HETATM 3675 O O   B HOH B 2 .   ? 8.48924   4.11868   -29.60819 0.395 15.12942 ? 603 HOH A O   1 
HETATM 3676 O O   . HOH B 2 .   ? 19.62364  5.70218   3.90444   1.000 32.22877 ? 604 HOH A O   1 
HETATM 3677 O O   . HOH B 2 .   ? 14.38205  12.14272  -13.60193 1.000 38.38402 ? 605 HOH A O   1 
HETATM 3678 O O   A HOH B 2 .   ? 17.551    -33.721   -11.337   0.311 21.13697 ? 606 HOH A O   1 
HETATM 3679 O O   B HOH B 2 .   ? 17.989    -33.744   -13.745   0.689 14.44470 ? 606 HOH A O   1 
HETATM 3680 O O   . HOH B 2 .   ? 13.67681  -21.94209 -21.43215 1.000 14.82366 ? 607 HOH A O   1 
HETATM 3681 O O   . HOH B 2 .   ? 37.45353  -4.35260  -25.38421 1.000 13.07003 ? 608 HOH A O   1 
HETATM 3682 O O   . HOH B 2 .   ? 5.92027   -23.99889 -18.74902 1.000 31.34608 ? 609 HOH A O   1 
HETATM 3683 O O   . HOH B 2 .   ? -6.41175  -18.58529 -24.98571 1.000 23.89232 ? 610 HOH A O   1 
HETATM 3684 O O   . HOH B 2 .   ? 7.14315   -18.88373 -15.31887 1.000 15.46011 ? 611 HOH A O   1 
HETATM 3685 O O   . HOH B 2 .   ? 14.69310  -13.76871 -31.25733 1.000 16.76472 ? 612 HOH A O   1 
HETATM 3686 O O   . HOH B 2 .   ? 17.326    9.959     -25.131   1.000 22.94481 ? 613 HOH A O   1 
HETATM 3687 O O   . HOH B 2 .   ? 7.98782   4.07690   -10.85772 1.000 18.90394 ? 614 HOH A O   1 
HETATM 3688 O O   . HOH B 2 .   ? -3.69771  -21.15590 -18.81964 1.000 34.38002 ? 615 HOH A O   1 
HETATM 3689 O O   . HOH B 2 .   ? 14.88549  2.66535   -33.66326 1.000 15.00078 ? 616 HOH A O   1 
HETATM 3690 O O   . HOH B 2 .   ? -1.22802  -0.18838  -12.29156 1.000 27.86881 ? 617 HOH A O   1 
HETATM 3691 O O   . HOH B 2 .   ? 6.66729   -13.18221 -13.91814 1.000 14.58715 ? 618 HOH A O   1 
HETATM 3692 O O   . HOH B 2 .   ? 9.89236   6.69083   -13.47404 1.000 18.57892 ? 619 HOH A O   1 
HETATM 3693 O O   . HOH B 2 .   ? -6.57374  -12.89922 -12.36154 1.000 35.62326 ? 620 HOH A O   1 
HETATM 3694 O O   A HOH B 2 .   ? 17.72708  -28.64685 -6.05001  0.519 18.59843 ? 621 HOH A O   1 
HETATM 3695 O O   B HOH B 2 .   ? 18.68827  -29.41534 -5.50700  0.481 19.86488 ? 621 HOH A O   1 
HETATM 3696 O O   . HOH B 2 .   ? 16.89451  -2.61603  -31.36807 1.000 13.20127 ? 622 HOH A O   1 
HETATM 3697 O O   . HOH B 2 .   ? 4.63861   14.87463  -15.28799 1.000 29.21539 ? 623 HOH A O   1 
HETATM 3698 O O   . HOH B 2 .   ? 17.93057  6.23567   -15.63003 1.000 33.08455 ? 624 HOH A O   1 
HETATM 3699 O O   . HOH B 2 .   ? 26.46203  -26.91694 -0.57463  1.000 28.69913 ? 625 HOH A O   1 
HETATM 3700 O O   . HOH B 2 .   ? 28.76840  -6.03198  -37.60753 1.000 26.30047 ? 626 HOH A O   1 
HETATM 3701 O O   . HOH B 2 .   ? 20.56993  -13.51939 8.05330   1.000 26.63904 ? 627 HOH A O   1 
HETATM 3702 O O   . HOH B 2 .   ? -3.62390  -7.19147  -14.57216 1.000 24.68575 ? 628 HOH A O   1 
HETATM 3703 O O   . HOH B 2 .   ? 20.06363  7.26550   -32.21237 1.000 19.21769 ? 629 HOH A O   1 
HETATM 3704 O O   . HOH B 2 .   ? 15.87865  -23.86119 5.42322   1.000 22.00493 ? 630 HOH A O   1 
HETATM 3705 O O   . HOH B 2 .   ? 25.68124  5.89917   7.16020   1.000 31.08464 ? 631 HOH A O   1 
HETATM 3706 O O   A HOH B 2 .   ? 11.19766  -2.76480  -6.00695  0.649 20.98416 ? 632 HOH A O   1 
HETATM 3707 O O   B HOH B 2 .   ? 10.87296  -2.20879  -4.21192  0.351 21.56752 ? 632 HOH A O   1 
HETATM 3708 O O   . HOH B 2 .   ? 37.73321  -19.26208 -27.23771 1.000 29.88320 ? 633 HOH A O   1 
HETATM 3709 O O   . HOH B 2 .   ? 24.84218  3.97174   -31.36858 1.000 13.06031 ? 634 HOH A O   1 
HETATM 3710 O O   . HOH B 2 .   ? 43.28858  -19.63985 -21.59188 1.000 19.92297 ? 635 HOH A O   1 
HETATM 3711 O O   . HOH B 2 .   ? -4.98189  -16.39097 -18.99154 1.000 26.60608 ? 636 HOH A O   1 
HETATM 3712 O O   . HOH B 2 .   ? 24.55270  -19.90966 3.38315   1.000 26.97833 ? 637 HOH A O   1 
HETATM 3713 O O   . HOH B 2 .   ? 30.90029  -10.69795 -0.30925  1.000 11.46105 ? 638 HOH A O   1 
HETATM 3714 O O   . HOH B 2 .   ? -0.608    -23.839   -18.785   1.000 23.78144 ? 639 HOH A O   1 
HETATM 3715 O O   . HOH B 2 .   ? 1.884     -17.088   -2.993    1.000 16.86955 ? 640 HOH A O   1 
HETATM 3716 O O   . HOH B 2 .   ? 35.80490  -10.78617 -29.24593 1.000 20.72975 ? 641 HOH A O   1 
HETATM 3717 O O   A HOH B 2 .   ? -4.882    -6.495    -32.703   0.480 22.85397 ? 642 HOH A O   1 
HETATM 3718 O O   B HOH B 2 .   ? -4.548    -5.029    -33.338   0.520 22.20402 ? 642 HOH A O   1 
HETATM 3719 O O   . HOH B 2 .   ? -2.94724  -0.79898  -15.87839 1.000 22.00516 ? 643 HOH A O   1 
HETATM 3720 O O   . HOH B 2 .   ? 2.29151   -17.13231 -16.08646 1.000 13.70141 ? 644 HOH A O   1 
HETATM 3721 O O   . HOH B 2 .   ? 9.48675   -4.87221  -29.32056 1.000 11.35270 ? 645 HOH A O   1 
HETATM 3722 O O   A HOH B 2 .   ? 8.10512   -17.39991 -12.48956 0.697 11.74632 ? 646 HOH A O   1 
HETATM 3723 O O   B HOH B 2 .   ? 8.85916   -17.57755 -12.44118 0.303 10.15141 ? 646 HOH A O   1 
HETATM 3724 O O   . HOH B 2 .   ? 3.01749   -10.72910 -4.08453  1.000 36.05038 ? 647 HOH A O   1 
HETATM 3725 O O   . HOH B 2 .   ? 11.98954  -9.29600  -33.40289 1.000 17.64135 ? 648 HOH A O   1 
HETATM 3726 O O   . HOH B 2 .   ? 4.91732   -16.91726 -16.78922 1.000 13.43666 ? 649 HOH A O   1 
HETATM 3727 O O   A HOH B 2 .   ? -0.35276  -11.46153 -31.60314 0.538 18.10479 ? 650 HOH A O   1 
HETATM 3728 O O   B HOH B 2 .   ? -0.42057  -12.39570 -32.53814 0.462 21.39541 ? 650 HOH A O   1 
HETATM 3729 O O   . HOH B 2 .   ? 33.38362  -22.13912 -28.31675 1.000 34.25423 ? 651 HOH A O   1 
HETATM 3730 O O   . HOH B 2 .   ? 11.59481  -25.05383 -27.24023 1.000 32.15410 ? 652 HOH A O   1 
HETATM 3731 O O   . HOH B 2 .   ? 10.02831  -5.70740  1.53855   1.000 16.15437 ? 653 HOH A O   1 
HETATM 3732 O O   . HOH B 2 .   ? 9.20481   -20.01746 -12.42681 1.000 13.90130 ? 654 HOH A O   1 
HETATM 3733 O O   . HOH B 2 .   ? 33.63158  -5.28509  -2.35823  1.000 14.09548 ? 655 HOH A O   1 
HETATM 3734 O O   . HOH B 2 .   ? 16.42008  -3.63029  -36.82766 1.000 13.87309 ? 656 HOH A O   1 
HETATM 3735 O O   . HOH B 2 .   ? 14.634    -1.011    4.417     1.000 19.38150 ? 657 HOH A O   1 
HETATM 3736 O O   . HOH B 2 .   ? 7.67782   -8.00155  -11.00643 1.000 20.76809 ? 658 HOH A O   1 
HETATM 3737 O O   A HOH B 2 .   ? 13.25750  -33.50649 -9.13232  0.756 24.82794 ? 659 HOH A O   1 
HETATM 3738 O O   B HOH B 2 .   ? 13.21178  -30.50200 -10.23835 0.244 12.70781 ? 659 HOH A O   1 
HETATM 3739 O O   . HOH B 2 .   ? 18.63033  3.53871   -5.19295  1.000 24.27288 ? 660 HOH A O   1 
HETATM 3740 O O   . HOH B 2 .   ? 31.61968  -21.26481 -4.70136  1.000 15.66699 ? 661 HOH A O   1 
HETATM 3741 O O   . HOH B 2 .   ? 0.93129   -9.93035  -33.68360 1.000 22.34233 ? 662 HOH A O   1 
HETATM 3742 O O   . HOH B 2 .   ? 39.68513  -10.02454 -14.10580 1.000 26.55951 ? 663 HOH A O   1 
HETATM 3743 O O   . HOH B 2 .   ? 5.05222   -26.36776 -14.69529 1.000 20.34268 ? 664 HOH A O   1 
HETATM 3744 O O   . HOH B 2 .   ? 20.82010  -4.50789  -16.84243 1.000 12.41724 ? 665 HOH A O   1 
HETATM 3745 O O   . HOH B 2 .   ? 6.67900   5.67714   -19.56566 1.000 14.68687 ? 666 HOH A O   1 
HETATM 3746 O O   . HOH B 2 .   ? 20.19797  -19.14549 4.68786   1.000 17.85558 ? 667 HOH A O   1 
HETATM 3747 O O   . HOH B 2 .   ? 31.50052  -21.61572 -13.50465 1.000 12.62636 ? 668 HOH A O   1 
HETATM 3748 O O   . HOH B 2 .   ? 26.07761  5.59966   -39.70553 1.000 25.69822 ? 669 HOH A O   1 
HETATM 3749 O O   . HOH B 2 .   ? 13.22834  -17.64708 4.48252   1.000 13.63042 ? 670 HOH A O   1 
HETATM 3750 O O   . HOH B 2 .   ? 29.54899  -24.55383 -15.26890 1.000 14.70883 ? 671 HOH A O   1 
HETATM 3751 O O   . HOH B 2 .   ? 3.83355   -23.66627 -20.50023 1.000 24.58144 ? 672 HOH A O   1 
HETATM 3752 O O   . HOH B 2 .   ? 14.978    9.837     -26.994   1.000 19.06987 ? 673 HOH A O   1 
HETATM 3753 O O   . HOH B 2 .   ? 27.61771  -25.21473 -26.74159 1.000 23.36570 ? 674 HOH A O   1 
HETATM 3754 O O   A HOH B 2 .   ? 16.82281  -8.27450  4.91009   0.610 13.74483 ? 675 HOH A O   1 
HETATM 3755 O O   B HOH B 2 .   ? 17.34265  -7.62424  5.49158   0.390 15.59995 ? 675 HOH A O   1 
HETATM 3756 O O   . HOH B 2 .   ? 10.59303  -33.19632 -16.51010 1.000 20.17727 ? 676 HOH A O   1 
HETATM 3757 O O   . HOH B 2 .   ? -16.15444 -7.01821  -26.75439 1.000 25.40619 ? 677 HOH A O   1 
HETATM 3758 O O   . HOH B 2 .   ? 24.97822  -7.86637  -12.89766 1.000 12.39866 ? 678 HOH A O   1 
HETATM 3759 O O   A HOH B 2 .   ? 19.227    -30.085   -17.330   0.428 13.32061 ? 679 HOH A O   1 
HETATM 3760 O O   B HOH B 2 .   ? 19.414    -30.294   -18.077   0.572 10.61120 ? 679 HOH A O   1 
HETATM 3761 O O   . HOH B 2 .   ? 12.44128  -19.74365 -19.98586 1.000 12.16596 ? 680 HOH A O   1 
HETATM 3762 O O   . HOH B 2 .   ? 34.81836  -19.85988 -28.91184 1.000 28.76994 ? 681 HOH A O   1 
HETATM 3763 O O   . HOH B 2 .   ? -0.91076  -21.46007 -24.82240 1.000 32.18590 ? 682 HOH A O   1 
HETATM 3764 O O   . HOH B 2 .   ? 13.12496  -8.32549  -24.81201 1.000 10.45778 ? 683 HOH A O   1 
HETATM 3765 O O   . HOH B 2 .   ? 14.44853  -19.71368 -31.82949 1.000 29.82318 ? 684 HOH A O   1 
HETATM 3766 O O   . HOH B 2 .   ? 18.08534  -4.93185  -16.93552 1.000 14.37597 ? 685 HOH A O   1 
HETATM 3767 O O   . HOH B 2 .   ? 10.96370  -11.74272 -32.82878 1.000 15.20072 ? 686 HOH A O   1 
HETATM 3768 O O   . HOH B 2 .   ? 18.62899  -25.66697 -8.68001  1.000 11.50302 ? 687 HOH A O   1 
HETATM 3769 O O   . HOH B 2 .   ? 20.69413  8.63088   -37.18987 1.000 33.34137 ? 688 HOH A O   1 
HETATM 3770 O O   . HOH B 2 .   ? 18.39485  7.52003   -22.88661 1.000 27.15484 ? 689 HOH A O   1 
HETATM 3771 O O   . HOH B 2 .   ? 17.47128  -4.79635  -34.47291 1.000 13.26375 ? 690 HOH A O   1 
HETATM 3772 O O   . HOH B 2 .   ? 22.75649  8.66739   -10.05545 1.000 22.76729 ? 691 HOH A O   1 
HETATM 3773 O O   . HOH B 2 .   ? 8.63725   -26.03660 -19.75959 1.000 24.52229 ? 692 HOH A O   1 
HETATM 3774 O O   . HOH B 2 .   ? 20.04842  -3.90843  -34.61071 1.000 13.84005 ? 693 HOH A O   1 
HETATM 3775 O O   . HOH B 2 .   ? 16.39274  -35.72215 -15.22916 1.000 23.74747 ? 694 HOH A O   1 
HETATM 3776 O O   . HOH B 2 .   ? 21.34153  5.64245   -30.35425 1.000 12.70360 ? 695 HOH A O   1 
HETATM 3777 O O   . HOH B 2 .   ? 10.99244  -9.07881  -21.53906 1.000 10.52382 ? 696 HOH A O   1 
HETATM 3778 O O   . HOH B 2 .   ? 14.39808  -0.19294  -31.00913 1.000 12.08539 ? 697 HOH A O   1 
HETATM 3779 O O   . HOH B 2 .   ? 6.11199   -3.92468  -19.77599 1.000 12.82528 ? 698 HOH A O   1 
HETATM 3780 O O   . HOH B 2 .   ? 34.69090  3.70290   -6.55024  1.000 26.86361 ? 699 HOH A O   1 
HETATM 3781 O O   . HOH B 2 .   ? 10.22459  -19.91461 -29.39913 1.000 16.23540 ? 700 HOH A O   1 
HETATM 3782 O O   . HOH B 2 .   ? 29.87942  -21.38456 -2.52908  1.000 13.69410 ? 701 HOH A O   1 
HETATM 3783 O O   . HOH B 2 .   ? 32.56420  0.58177   -31.95729 1.000 15.88783 ? 702 HOH A O   1 
HETATM 3784 O O   . HOH B 2 .   ? 11.31529  -17.35936 -19.52198 1.000 10.21561 ? 703 HOH A O   1 
HETATM 3785 O O   . HOH B 2 .   ? -1.759    -35.342   -7.623    1.000 21.92934 ? 704 HOH A O   1 
HETATM 3786 O O   . HOH B 2 .   ? 11.72607  -12.66543 7.37849   1.000 22.66093 ? 705 HOH A O   1 
HETATM 3787 O O   . HOH B 2 .   ? 30.25941  -28.54278 -21.25478 1.000 31.08799 ? 706 HOH A O   1 
HETATM 3788 O O   . HOH B 2 .   ? 7.81251   -21.66733 2.34266   1.000 14.34199 ? 707 HOH A O   1 
HETATM 3789 O O   . HOH B 2 .   ? 9.28532   -13.76550 -36.49197 1.000 29.44981 ? 708 HOH A O   1 
HETATM 3790 O O   . HOH B 2 .   ? 8.07692   -20.94346 -24.18331 1.000 15.97380 ? 709 HOH A O   1 
HETATM 3791 O O   . HOH B 2 .   ? 18.68302  -28.80325 0.22425   1.000 27.28046 ? 710 HOH A O   1 
HETATM 3792 O O   . HOH B 2 .   ? 22.55515  -18.18092 3.21638   1.000 20.61675 ? 711 HOH A O   1 
HETATM 3793 O O   A HOH B 2 .   ? 25.607    5.939     -18.856   0.589 19.24833 ? 712 HOH A O   1 
HETATM 3794 O O   B HOH B 2 .   ? 26.561    3.584     -19.239   0.411 21.22369 ? 712 HOH A O   1 
HETATM 3795 O O   . HOH B 2 .   ? 19.664    7.041     8.441     1.000 24.05172 ? 713 HOH A O   1 
HETATM 3796 O O   . HOH B 2 .   ? -12.940   -3.511    -21.349   1.000 30.09670 ? 714 HOH A O   1 
HETATM 3797 O O   . HOH B 2 .   ? 41.024    -21.414   -9.269    1.000 31.79281 ? 715 HOH A O   1 
HETATM 3798 O O   . HOH B 2 .   ? 26.06094  -26.88388 -3.92334  1.000 18.74390 ? 716 HOH A O   1 
HETATM 3799 O O   . HOH B 2 .   ? 25.49966  -18.90981 -33.94611 1.000 25.72374 ? 717 HOH A O   1 
HETATM 3800 O O   . HOH B 2 .   ? 5.70345   -11.10536 -12.44783 1.000 14.77887 ? 718 HOH A O   1 
HETATM 3801 O O   . HOH B 2 .   ? 34.74080  -1.76967  -12.11701 1.000 27.82706 ? 719 HOH A O   1 
HETATM 3802 O O   . HOH B 2 .   ? 13.07188  -2.99198  -2.76366  1.000 16.17954 ? 720 HOH A O   1 
HETATM 3803 O O   . HOH B 2 .   ? 21.42169  -28.14578 -8.54287  1.000 11.71027 ? 721 HOH A O   1 
HETATM 3804 O O   . HOH B 2 .   ? 30.48594  -10.60242 -32.86634 1.000 19.64190 ? 722 HOH A O   1 
HETATM 3805 O O   . HOH B 2 .   ? 32.982    3.124     -23.871   1.000 13.68466 ? 723 HOH A O   1 
HETATM 3806 O O   . HOH B 2 .   ? 26.984    2.175     5.876     1.000 28.91228 ? 724 HOH A O   1 
HETATM 3807 O O   . HOH B 2 .   ? 24.28731  -5.53424  -14.41886 1.000 10.23597 ? 725 HOH A O   1 
HETATM 3808 O O   . HOH B 2 .   ? -0.97878  5.08450   -21.33819 1.000 23.65573 ? 726 HOH A O   1 
HETATM 3809 O O   . HOH B 2 .   ? 18.15560  -25.02720 -6.03479  1.000 17.10115 ? 727 HOH A O   1 
HETATM 3810 O O   . HOH B 2 .   ? 10.49708  -5.44474  -36.05943 1.000 16.98234 ? 728 HOH A O   1 
HETATM 3811 O O   A HOH B 2 .   ? 25.41855  -1.06168  -36.23964 0.410 13.17368 ? 729 HOH A O   1 
HETATM 3812 O O   B HOH B 2 .   ? 24.41472  0.49731   -37.06137 0.321 12.10274 ? 729 HOH A O   1 
HETATM 3813 O O   C HOH B 2 .   ? 26.67178  -1.20852  -36.79372 0.269 11.22661 ? 729 HOH A O   1 
HETATM 3814 O O   . HOH B 2 .   ? 9.34693   -11.47852 3.87924   1.000 20.64370 ? 730 HOH A O   1 
HETATM 3815 O O   . HOH B 2 .   ? 27.73475  1.11110   -37.30024 1.000 23.74661 ? 731 HOH A O   1 
HETATM 3816 O O   . HOH B 2 .   ? 7.72422   -10.74884 -10.63419 1.000 13.78127 ? 732 HOH A O   1 
HETATM 3817 O O   A HOH B 2 .   ? 22.875    3.943     9.340     0.488 16.86192 ? 733 HOH A O   1 
HETATM 3818 O O   B HOH B 2 .   ? 24.014    3.446     9.648     0.512 16.00408 ? 733 HOH A O   1 
HETATM 3819 O O   . HOH B 2 .   ? 3.28386   0.56674   -26.43474 1.000 14.95245 ? 734 HOH A O   1 
HETATM 3820 O O   . HOH B 2 .   ? 15.42475  -9.97355  8.96315   1.000 33.44424 ? 735 HOH A O   1 
HETATM 3821 O O   . HOH B 2 .   ? 17.20092  -2.20590  -2.41146  1.000 12.52585 ? 736 HOH A O   1 
HETATM 3822 O O   . HOH B 2 .   ? 23.26633  7.05528   -2.34013  1.000 27.58253 ? 737 HOH A O   1 
HETATM 3823 O O   A HOH B 2 .   ? 2.59819   -20.82033 -5.27122  0.473 13.29984 ? 738 HOH A O   1 
HETATM 3824 O O   B HOH B 2 .   ? 0.81973   -21.22225 -7.05188  0.527 24.56191 ? 738 HOH A O   1 
HETATM 3825 O O   . HOH B 2 .   ? 30.939    -25.238   -29.287   1.000 27.81780 ? 739 HOH A O   1 
HETATM 3826 O O   . HOH B 2 .   ? -9.31167  -12.10383 -13.51802 1.000 31.32642 ? 740 HOH A O   1 
HETATM 3827 O O   . HOH B 2 .   ? 25.12370  -23.60759 -24.68852 1.000 18.04201 ? 741 HOH A O   1 
HETATM 3828 O O   . HOH B 2 .   ? 22.60367  1.82400   -24.68781 1.000 21.89004 ? 742 HOH A O   1 
HETATM 3829 O O   . HOH B 2 .   ? 1.16462   8.03984   -14.28992 1.000 27.15387 ? 743 HOH A O   1 
HETATM 3830 O O   . HOH B 2 .   ? 16.66485  10.54234  -35.92000 1.000 26.58474 ? 744 HOH A O   1 
HETATM 3831 O O   . HOH B 2 .   ? 12.03559  -6.52229  -21.82716 1.000 10.36043 ? 745 HOH A O   1 
HETATM 3832 O O   . HOH B 2 .   ? 6.61674   -12.58532 -6.11869  1.000 23.86131 ? 746 HOH A O   1 
HETATM 3833 O O   . HOH B 2 .   ? 1.05151   -27.68823 -7.18567  1.000 20.96556 ? 747 HOH A O   1 
HETATM 3834 O O   . HOH B 2 .   ? 23.95408  -12.41004 6.90971   1.000 25.70684 ? 748 HOH A O   1 
HETATM 3835 O O   A HOH B 2 .   ? 2.70329   11.45259  -17.68614 0.470 18.96303 ? 749 HOH A O   1 
HETATM 3836 O O   B HOH B 2 .   ? 1.92284   10.68350  -16.29887 0.530 24.31597 ? 749 HOH A O   1 
HETATM 3837 O O   . HOH B 2 .   ? 37.27693  -5.08071  -28.70543 1.000 34.16136 ? 750 HOH A O   1 
HETATM 3838 O O   . HOH B 2 .   ? 33.27665  3.49670   -15.88232 1.000 17.43358 ? 751 HOH A O   1 
HETATM 3839 O O   . HOH B 2 .   ? 19.63991  4.39953   -1.71284  1.000 27.99006 ? 752 HOH A O   1 
HETATM 3840 O O   . HOH B 2 .   ? 27.07551  -15.09862 6.29121   1.000 35.32777 ? 753 HOH A O   1 
HETATM 3841 O O   . HOH B 2 .   ? 27.77539  -27.95544 -18.59989 1.000 17.53283 ? 754 HOH A O   1 
HETATM 3842 O O   . HOH B 2 .   ? 33.421    -26.217   -19.646   1.000 35.14901 ? 755 HOH A O   1 
HETATM 3843 O O   . HOH B 2 .   ? 18.17682  -7.34195  8.06346   1.000 31.43226 ? 756 HOH A O   1 
HETATM 3844 O O   . HOH B 2 .   ? 32.68248  1.89706   -3.80494  1.000 14.40911 ? 757 HOH A O   1 
HETATM 3845 O O   . HOH B 2 .   ? 26.12713  -1.15462  3.38274   1.000 16.16574 ? 758 HOH A O   1 
HETATM 3846 O O   A HOH B 2 .   ? 18.24210  -29.92762 -10.32365 0.429 11.58075 ? 759 HOH A O   1 
HETATM 3847 O O   B HOH B 2 .   ? 18.52400  -28.65249 -9.95255  0.571 19.07526 ? 759 HOH A O   1 
HETATM 3848 O O   . HOH B 2 .   ? 23.01284  -29.29942 -23.06236 1.000 17.37090 ? 760 HOH A O   1 
HETATM 3849 O O   . HOH B 2 .   ? 27.554    6.483     -32.253   1.000 14.66646 ? 761 HOH A O   1 
HETATM 3850 O O   . HOH B 2 .   ? 3.23787   -24.34263 -13.97946 1.000 16.82877 ? 762 HOH A O   1 
HETATM 3851 O O   A HOH B 2 .   ? 25.37330  -3.55302  9.75056   0.563 18.79742 ? 763 HOH A O   1 
HETATM 3852 O O   B HOH B 2 .   ? 24.54108  -4.78025  10.51116  0.437 25.65991 ? 763 HOH A O   1 
HETATM 3853 O O   A HOH B 2 .   ? 23.315    11.261    -27.941   0.587 12.97746 ? 764 HOH A O   1 
HETATM 3854 O O   B HOH B 2 .   ? 24.183    11.726    -27.602   0.413 14.96794 ? 764 HOH A O   1 
HETATM 3855 O O   . HOH B 2 .   ? 29.45071  -24.17008 -24.05893 1.000 31.17383 ? 765 HOH A O   1 
HETATM 3856 O O   . HOH B 2 .   ? 29.45957  -18.86103 -32.85922 1.000 26.51413 ? 766 HOH A O   1 
HETATM 3857 O O   . HOH B 2 .   ? 23.15018  5.04915   0.69988   1.000 16.93754 ? 767 HOH A O   1 
HETATM 3858 O O   . HOH B 2 .   ? 19.48220  -5.26693  -20.55672 1.000 14.38970 ? 768 HOH A O   1 
HETATM 3859 O O   . HOH B 2 .   ? 29.84861  4.11201   -0.04503  1.000 28.77838 ? 769 HOH A O   1 
HETATM 3860 O O   . HOH B 2 .   ? 16.10099  -13.54993 -35.29104 1.000 27.37754 ? 770 HOH A O   1 
HETATM 3861 O O   . HOH B 2 .   ? 13.35737  -2.71608  -30.31914 1.000 12.27861 ? 771 HOH A O   1 
HETATM 3862 O O   A HOH B 2 .   ? 17.77930  -27.27761 -2.16002  0.643 20.77135 ? 772 HOH A O   1 
HETATM 3863 O O   B HOH B 2 .   ? 19.03568  -27.64255 -4.03038  0.357 17.86006 ? 772 HOH A O   1 
HETATM 3864 O O   . HOH B 2 .   ? 14.36621  4.41209   -12.64911 1.000 21.64102 ? 773 HOH A O   1 
HETATM 3865 O O   . HOH B 2 .   ? 21.80719  -18.90557 -35.82753 1.000 27.38281 ? 774 HOH A O   1 
HETATM 3866 O O   . HOH B 2 .   ? -0.46414  -20.29677 -16.11952 1.000 19.15945 ? 775 HOH A O   1 
HETATM 3867 O O   . HOH B 2 .   ? 1.84044   -33.91547 -5.60870  1.000 17.95202 ? 776 HOH A O   1 
HETATM 3868 O O   . HOH B 2 .   ? 27.75537  -21.89584 4.86503   1.000 28.31345 ? 777 HOH A O   1 
HETATM 3869 O O   . HOH B 2 .   ? 33.80887  1.07966   -20.22219 1.000 16.80886 ? 778 HOH A O   1 
HETATM 3870 O O   . HOH B 2 .   ? 26.78912  -27.21188 -14.75840 1.000 13.70277 ? 779 HOH A O   1 
HETATM 3871 O O   A HOH B 2 .   ? 25.83507  -2.99161  5.64049   0.591 14.59678 ? 780 HOH A O   1 
HETATM 3872 O O   B HOH B 2 .   ? 26.61188  -1.63873  6.20832   0.409 15.65345 ? 780 HOH A O   1 
HETATM 3873 O O   . HOH B 2 .   ? 3.293     -34.567   -17.795   1.000 20.23042 ? 781 HOH A O   1 
HETATM 3874 O O   . HOH B 2 .   ? 3.042     -31.636   -17.744   1.000 29.28583 ? 782 HOH A O   1 
HETATM 3875 O O   . HOH B 2 .   ? 12.14190  -11.46729 -30.28637 1.000 12.04232 ? 783 HOH A O   1 
HETATM 3876 O O   . HOH B 2 .   ? 28.80546  -25.54322 -17.74261 1.000 18.07186 ? 784 HOH A O   1 
HETATM 3877 O O   . HOH B 2 .   ? 21.923    -26.485   -25.038   1.000 18.53367 ? 785 HOH A O   1 
HETATM 3878 O O   . HOH B 2 .   ? 7.36902   -10.32314 -21.89605 1.000 16.43775 ? 786 HOH A O   1 
HETATM 3879 O O   . HOH B 2 .   ? 35.59423  -0.34064  -16.26856 1.000 30.34326 ? 787 HOH A O   1 
HETATM 3880 O O   . HOH B 2 .   ? 25.38503  10.15944  -9.09111  1.000 18.65958 ? 788 HOH A O   1 
HETATM 3881 O O   . HOH B 2 .   ? 12.34046  5.47578   -22.34905 1.000 15.50739 ? 789 HOH A O   1 
HETATM 3882 O O   A HOH B 2 .   ? 20.02864  0.56148   -21.59729 0.584 18.22263 ? 790 HOH A O   1 
HETATM 3883 O O   B HOH B 2 .   ? 21.71692  1.25340   -22.22238 0.416 20.66864 ? 790 HOH A O   1 
HETATM 3884 O O   . HOH B 2 .   ? 11.82417  3.77534   -13.27605 1.000 25.01658 ? 791 HOH A O   1 
HETATM 3885 O O   A HOH B 2 .   ? 15.16915  -27.00339 -28.23913 0.447 19.87885 ? 792 HOH A O   1 
HETATM 3886 O O   B HOH B 2 .   ? 17.64008  -21.97758 -34.52355 0.553 26.73305 ? 792 HOH A O   1 
HETATM 3887 O O   . HOH B 2 .   ? 2.33166   7.72815   -25.12021 1.000 22.28946 ? 793 HOH A O   1 
HETATM 3888 O O   . HOH B 2 .   ? 37.11155  2.02969   -9.44775  1.000 30.67444 ? 794 HOH A O   1 
HETATM 3889 O O   . HOH B 2 .   ? 11.95860  10.36435  -30.86804 1.000 31.35526 ? 795 HOH A O   1 
HETATM 3890 O O   . HOH B 2 .   ? 21.78183  6.27956   -26.26486 1.000 17.40219 ? 796 HOH A O   1 
HETATM 3891 O O   A HOH B 2 .   ? 10.698    -16.498   4.250     0.697 12.36906 ? 797 HOH A O   1 
HETATM 3892 O O   B HOH B 2 .   ? 9.896     -16.431   3.518     0.303 12.78814 ? 797 HOH A O   1 
HETATM 3893 O O   . HOH B 2 .   ? 5.86379   14.25900  -21.32788 1.000 30.95810 ? 798 HOH A O   1 
HETATM 3894 O O   . HOH B 2 .   ? 15.91259  -11.60983 -32.80594 1.000 15.84801 ? 799 HOH A O   1 
HETATM 3895 O O   . HOH B 2 .   ? 19.00809  -4.77059  -31.35990 1.000 12.50694 ? 800 HOH A O   1 
HETATM 3896 O O   A HOH B 2 .   ? 4.64084   -12.54585 0.37157   0.569 17.70058 ? 801 HOH A O   1 
HETATM 3897 O O   B HOH B 2 .   ? 5.79743   -12.47033 -0.99700  0.431 17.69519 ? 801 HOH A O   1 
HETATM 3898 O O   . HOH B 2 .   ? 12.90525  -25.15261 -24.90259 1.000 19.43564 ? 802 HOH A O   1 
HETATM 3899 O O   . HOH B 2 .   ? -2.896    -17.792   -7.801    1.000 30.69548 ? 803 HOH A O   1 
HETATM 3900 O O   A HOH B 2 .   ? 39.520    -21.800   -15.162   0.364 26.69143 ? 804 HOH A O   1 
HETATM 3901 O O   B HOH B 2 .   ? 40.286    -20.639   -14.190   0.636 16.38578 ? 804 HOH A O   1 
HETATM 3902 O O   . HOH B 2 .   ? 25.146    0.700     12.028    1.000 22.87170 ? 805 HOH A O   1 
HETATM 3903 O O   . HOH B 2 .   ? 1.15633   3.12194   -10.02341 1.000 27.47653 ? 806 HOH A O   1 
HETATM 3904 O O   . HOH B 2 .   ? -3.19287  1.30764   -19.09586 1.000 19.93679 ? 807 HOH A O   1 
HETATM 3905 O O   . HOH B 2 .   ? 15.95230  -13.40704 8.78447   1.000 31.13956 ? 808 HOH A O   1 
HETATM 3906 O O   . HOH B 2 .   ? 13.47042  -9.12692  6.47931   1.000 25.48176 ? 809 HOH A O   1 
HETATM 3907 O O   . HOH B 2 .   ? -0.42299  -4.00479  -10.55305 1.000 24.26397 ? 810 HOH A O   1 
HETATM 3908 O O   . HOH B 2 .   ? -6.06080  -0.42613  -22.67764 1.000 32.08451 ? 811 HOH A O   1 
HETATM 3909 O O   A HOH B 2 .   ? 11.75748  -2.93538  -15.22956 0.668 24.58360 ? 812 HOH A O   1 
HETATM 3910 O O   B HOH B 2 .   ? 12.80578  -1.75250  -16.66744 0.332 14.04271 ? 812 HOH A O   1 
HETATM 3911 O O   . HOH B 2 .   ? 22.29914  -28.01843 -0.92913  1.000 32.58615 ? 813 HOH A O   1 
HETATM 3912 O O   . HOH B 2 .   ? -4.40377  -17.26904 -16.54296 1.000 31.48310 ? 814 HOH A O   1 
HETATM 3913 O O   A HOH B 2 .   ? 18.53143  -1.67253  -19.98862 0.631 18.06030 ? 815 HOH A O   1 
HETATM 3914 O O   B HOH B 2 .   ? 17.80344  -3.03253  -19.99291 0.369 15.80117 ? 815 HOH A O   1 
HETATM 3915 O O   A HOH B 2 .   ? -0.12916  -30.50761 -8.22820  0.592 15.55521 ? 816 HOH A O   1 
HETATM 3916 O O   B HOH B 2 .   ? -0.78237  -29.94995 -6.93788  0.408 15.18018 ? 816 HOH A O   1 
HETATM 3917 O O   . HOH B 2 .   ? 9.162     15.473    -19.784   1.000 33.81393 ? 817 HOH A O   1 
HETATM 3918 O O   . HOH B 2 .   ? 5.58670   -31.99270 -2.94463  1.000 18.63865 ? 818 HOH A O   1 
HETATM 3919 O O   . HOH B 2 .   ? 4.00853   -10.82943 -36.24124 1.000 26.54397 ? 819 HOH A O   1 
HETATM 3920 O O   A HOH B 2 .   ? -1.53302  -11.06647 -9.98031  0.503 23.67505 ? 820 HOH A O   1 
HETATM 3921 O O   B HOH B 2 .   ? -1.75836  -12.25246 -7.44606  0.497 31.70598 ? 820 HOH A O   1 
HETATM 3922 O O   . HOH B 2 .   ? 8.53327   -18.00303 -30.79356 1.000 16.49060 ? 821 HOH A O   1 
HETATM 3923 O O   . HOH B 2 .   ? 6.14958   -6.61581  -9.04663  1.000 31.61363 ? 822 HOH A O   1 
HETATM 3924 O O   . HOH B 2 .   ? 33.75349  0.43763   -29.44984 1.000 13.99545 ? 823 HOH A O   1 
HETATM 3925 O O   . HOH B 2 .   ? 12.87382  -5.16566  4.77656   1.000 33.92589 ? 824 HOH A O   1 
HETATM 3926 O O   . HOH B 2 .   ? 26.24760  -16.28792 -34.97635 1.000 26.42899 ? 825 HOH A O   1 
HETATM 3927 O O   . HOH B 2 .   ? 3.59719   -22.14243 -24.02914 1.000 30.74991 ? 826 HOH A O   1 
HETATM 3928 O O   . HOH B 2 .   ? 20.720    7.509     -39.934   1.000 36.24257 ? 827 HOH A O   1 
HETATM 3929 O O   . HOH B 2 .   ? 40.19536  -7.47113  -11.76527 1.000 39.07628 ? 828 HOH A O   1 
HETATM 3930 O O   . HOH B 2 .   ? 33.57720  -7.00079  -31.41071 1.000 17.17981 ? 829 HOH A O   1 
HETATM 3931 O O   A HOH B 2 .   ? -13.059   -12.257   -24.166   0.616 28.22835 ? 830 HOH A O   1 
HETATM 3932 O O   B HOH B 2 .   ? -14.190   -15.860   -27.757   0.384 21.04260 ? 830 HOH A O   1 
HETATM 3933 O O   . HOH B 2 .   ? 18.54427  -27.15888 -27.60134 1.000 31.98089 ? 831 HOH A O   1 
HETATM 3934 O O   . HOH B 2 .   ? 25.36722  3.60054   -26.80412 1.000 17.44672 ? 832 HOH A O   1 
HETATM 3935 O O   . HOH B 2 .   ? 35.27792  -24.40937 -8.84925  1.000 30.39578 ? 833 HOH A O   1 
HETATM 3936 O O   . HOH B 2 .   ? 10.88934  15.63943  -11.24321 1.000 34.30291 ? 834 HOH A O   1 
HETATM 3937 O O   A HOH B 2 .   ? 34.90510  -8.05332  -7.49570  0.618 19.82520 ? 835 HOH A O   1 
HETATM 3938 O O   B HOH B 2 .   ? 33.94851  -8.91715  -6.22229  0.382 17.08832 ? 835 HOH A O   1 
HETATM 3939 O O   A HOH B 2 .   ? 32.98907  -9.77083  -6.30782  0.552 14.84329 ? 836 HOH A O   1 
HETATM 3940 O O   B HOH B 2 .   ? 31.56154  -9.63435  -6.92571  0.448 14.32341 ? 836 HOH A O   1 
HETATM 3941 O O   . HOH B 2 .   ? 27.188    12.021    -11.007   1.000 8.46200  ? 837 HOH A O   1 
HETATM 3942 O O   A HOH B 2 .   ? 19.81300  7.21030   -34.97260 0.410 17.53913 ? 838 HOH A O   1 
HETATM 3943 O O   B HOH B 2 .   ? 17.36486  6.49786   -34.54548 0.590 26.11940 ? 838 HOH A O   1 
HETATM 3944 O O   . HOH B 2 .   ? 3.27989   -8.56547  -4.95672  1.000 39.67461 ? 839 HOH A O   1 
HETATM 3945 O O   . HOH B 2 .   ? 29.52406  -12.24840 -34.62248 1.000 24.45565 ? 840 HOH A O   1 
HETATM 3946 O O   A HOH B 2 .   ? 24.23357  3.32424   -19.11844 0.491 23.95187 ? 841 HOH A O   1 
HETATM 3947 O O   B HOH B 2 .   ? 23.66243  2.19042   -20.47293 0.509 24.63091 ? 841 HOH A O   1 
HETATM 3948 O O   . HOH B 2 .   ? 11.32200  -35.30430 -9.08987  1.000 34.27484 ? 842 HOH A O   1 
HETATM 3949 O O   . HOH B 2 .   ? 14.72628  -8.04130  -36.75044 1.000 17.98808 ? 843 HOH A O   1 
HETATM 3950 O O   . HOH B 2 .   ? 33.77285  5.31651   -17.95591 1.000 20.28468 ? 844 HOH A O   1 
HETATM 3951 O O   . HOH B 2 .   ? 11.49752  -8.02319  -35.81050 1.000 24.12024 ? 845 HOH A O   1 
HETATM 3952 O O   . HOH B 2 .   ? 23.88551  -22.70896 3.59154   1.000 35.77144 ? 846 HOH A O   1 
HETATM 3953 O O   . HOH B 2 .   ? 5.37652   -5.33017  -6.48237  1.000 38.37749 ? 847 HOH A O   1 
HETATM 3954 O O   . HOH B 2 .   ? 27.59902  5.23120   -1.15199  1.000 29.39089 ? 848 HOH A O   1 
HETATM 3955 O O   . HOH B 2 .   ? 34.43538  -13.93960 -32.06492 1.000 27.95052 ? 849 HOH A O   1 
HETATM 3956 O O   . HOH B 2 .   ? 14.51909  -9.84106  -34.50569 1.000 25.94951 ? 850 HOH A O   1 
HETATM 3957 O O   . HOH B 2 .   ? 33.27177  -9.88960  -1.71005  1.000 15.42491 ? 851 HOH A O   1 
HETATM 3958 O O   . HOH B 2 .   ? 10.43845  -2.26510  -1.88549  1.000 28.36186 ? 852 HOH A O   1 
HETATM 3959 O O   . HOH B 2 .   ? 33.65831  -7.84976  -3.37505  1.000 16.40309 ? 853 HOH A O   1 
HETATM 3960 O O   . HOH B 2 .   ? 15.16789  -0.01975  -14.34422 1.000 29.80558 ? 854 HOH A O   1 
HETATM 3961 O O   A HOH B 2 .   ? 12.76179  9.99602   -27.66342 0.437 28.61843 ? 855 HOH A O   1 
HETATM 3962 O O   B HOH B 2 .   ? 13.02276  11.01517  -28.66209 0.563 19.29438 ? 855 HOH A O   1 
HETATM 3963 O O   . HOH B 2 .   ? 19.15244  -3.56204  10.39112  1.000 32.67708 ? 856 HOH A O   1 
HETATM 3964 O O   . HOH B 2 .   ? 0.04162   -20.34069 -13.39562 1.000 25.91720 ? 857 HOH A O   1 
HETATM 3965 O O   . HOH B 2 .   ? 30.11886  -0.05602  -36.77667 1.000 24.94575 ? 858 HOH A O   1 
HETATM 3966 O O   . HOH B 2 .   ? 2.852     -29.632   -19.324   1.000 35.46794 ? 859 HOH A O   1 
HETATM 3967 O O   . HOH B 2 .   ? 36.07690  0.79675   -18.77515 1.000 24.78209 ? 860 HOH A O   1 
HETATM 3968 O O   . HOH B 2 .   ? 14.44310  2.68721   -39.03121 1.000 30.01773 ? 861 HOH A O   1 
HETATM 3969 O O   . HOH B 2 .   ? 26.09334  7.83251   -3.14841  1.000 29.56687 ? 862 HOH A O   1 
HETATM 3970 O O   . HOH B 2 .   ? 14.07321  3.68607   -36.17358 1.000 23.87622 ? 863 HOH A O   1 
HETATM 3971 O O   A HOH B 2 .   ? 6.21023   -11.19211 -8.21036  0.431 17.28046 ? 864 HOH A O   1 
HETATM 3972 O O   B HOH B 2 .   ? 7.41963   -10.52579 -7.82664  0.569 15.48211 ? 864 HOH A O   1 
HETATM 3973 O O   . HOH B 2 .   ? 23.32027  4.38060   -25.00006 1.000 20.11484 ? 865 HOH A O   1 
HETATM 3974 O O   . HOH B 2 .   ? 41.14532  -18.09023 -8.51514  1.000 35.69418 ? 866 HOH A O   1 
HETATM 3975 O O   . HOH B 2 .   ? 28.79546  -23.89596 -3.34232  1.000 16.74766 ? 867 HOH A O   1 
HETATM 3976 O O   . HOH B 2 .   ? 8.79958   -30.93540 -0.68596  1.000 29.52751 ? 868 HOH A O   1 
HETATM 3977 O O   A HOH B 2 .   ? 22.95604  -2.82796  12.50141  0.426 20.10234 ? 869 HOH A O   1 
HETATM 3978 O O   B HOH B 2 .   ? 24.97732  -1.54505  13.26106  0.574 27.38537 ? 869 HOH A O   1 
HETATM 3979 O O   . HOH B 2 .   ? 8.747     15.529    -22.420   1.000 33.39671 ? 870 HOH A O   1 
HETATM 3980 O O   . HOH B 2 .   ? 16.83886  -0.12901  5.30774   1.000 25.43651 ? 871 HOH A O   1 
HETATM 3981 O O   . HOH B 2 .   ? 43.44928  -13.09532 -8.74901  1.000 41.05793 ? 872 HOH A O   1 
HETATM 3982 O O   . HOH B 2 .   ? 1.15348   1.50504   -24.61088 1.000 22.81114 ? 873 HOH A O   1 
HETATM 3983 O O   . HOH B 2 .   ? 8.26756   -3.89253  0.02107   1.000 32.12528 ? 874 HOH A O   1 
HETATM 3984 O O   . HOH B 2 .   ? 33.04138  3.16121   -1.35114  1.000 26.69795 ? 875 HOH A O   1 
HETATM 3985 O O   . HOH B 2 .   ? 16.04683  -31.25155 -9.77686  1.000 31.80059 ? 876 HOH A O   1 
HETATM 3986 O O   . HOH B 2 .   ? 9.00795   -23.05466 -22.73623 1.000 25.76345 ? 877 HOH A O   1 
HETATM 3987 O O   . HOH B 2 .   ? 6.35059   -19.15663 -31.78561 1.000 31.34551 ? 878 HOH A O   1 
HETATM 3988 O O   . HOH B 2 .   ? 11.49043  -13.67772 -34.67710 1.000 22.98543 ? 879 HOH A O   1 
HETATM 3989 O O   A HOH B 2 .   ? 16.40956  0.46140   -41.22475 0.440 23.01309 ? 880 HOH A O   1 
HETATM 3990 O O   B HOH B 2 .   ? 15.73355  -0.32710  -41.63591 0.560 18.51031 ? 880 HOH A O   1 
HETATM 3991 O O   . HOH B 2 .   ? 2.27999   13.24945  -15.69878 1.000 32.86634 ? 881 HOH A O   1 
HETATM 3992 O O   . HOH B 2 .   ? 11.86797  -23.54372 -22.84995 1.000 19.57072 ? 882 HOH A O   1 
HETATM 3993 O O   . HOH B 2 .   ? 7.79370   6.49592   -30.55631 1.000 29.76037 ? 883 HOH A O   1 
HETATM 3994 O O   . HOH B 2 .   ? 33.14736  2.38840   0.91724   1.000 32.73862 ? 884 HOH A O   1 
HETATM 3995 O O   . HOH B 2 .   ? 25.81638  5.89449   0.79249   1.000 21.64391 ? 885 HOH A O   1 
HETATM 3996 O O   . HOH B 2 .   ? 33.712    -22.978   -4.122    1.000 30.94552 ? 886 HOH A O   1 
HETATM 3997 O O   . HOH B 2 .   ? 33.08745  -11.65379 -32.59630 1.000 26.30395 ? 887 HOH A O   1 
HETATM 3998 O O   . HOH B 2 .   ? 13.98647  -12.59039 -35.90304 1.000 37.84380 ? 888 HOH A O   1 
HETATM 3999 O O   . HOH B 2 .   ? 14.62078  -5.25660  -38.15058 1.000 26.19952 ? 889 HOH A O   1 
HETATM 4000 O O   . HOH B 2 .   ? 31.40107  -16.98237 -33.04855 1.000 27.32918 ? 890 HOH A O   1 
HETATM 4001 O O   . HOH B 2 .   ? -17.25900 -8.43116  -28.82665 1.000 29.15265 ? 891 HOH A O   1 
HETATM 4002 O O   . HOH B 2 .   ? 24.08064  -28.66212 -4.37561  1.000 24.64014 ? 892 HOH A O   1 
HETATM 4003 O O   . HOH B 2 .   ? -1.75214  1.91218   -16.66757 1.000 23.64311 ? 893 HOH A O   1 
HETATM 4004 O O   . HOH B 2 .   ? 18.81206  -28.37143 -8.00289  1.000 21.76867 ? 894 HOH A O   1 
HETATM 4005 O O   . HOH B 2 .   ? -1.00106  6.32152   -14.99014 1.000 27.37571 ? 895 HOH A O   1 
HETATM 4006 O O   . HOH B 2 .   ? 19.005    -36.774   -9.904    1.000 31.88361 ? 896 HOH A O   1 
HETATM 4007 O O   . HOH B 2 .   ? 16.40927  -1.19284  -18.12230 1.000 21.07439 ? 897 HOH A O   1 
HETATM 4008 O O   . HOH B 2 .   ? 37.661    -24.141   -6.100    1.000 31.16941 ? 898 HOH A O   1 
HETATM 4009 O O   . HOH B 2 .   ? 0.24478   11.78790  -7.13558  1.000 39.88812 ? 899 HOH A O   1 
HETATM 4010 O O   . HOH B 2 .   ? 37.31512  -6.34678  -11.52309 1.000 30.83621 ? 900 HOH A O   1 
HETATM 4011 O O   . HOH B 2 .   ? 8.93877   -22.15694 -28.87832 1.000 30.33457 ? 901 HOH A O   1 
HETATM 4012 O O   . HOH B 2 .   ? 8.69405   -6.00958  3.79393   1.000 28.13384 ? 902 HOH A O   1 
HETATM 4013 O O   . HOH B 2 .   ? 0.20971   3.96900   -23.71007 1.000 27.24598 ? 903 HOH A O   1 
HETATM 4014 O O   . HOH B 2 .   ? 34.000    -4.350    0.323     1.000 22.88377 ? 904 HOH A O   1 
HETATM 4015 O O   . HOH B 2 .   ? 23.01462  6.99008   -28.73693 1.000 14.71399 ? 905 HOH A O   1 
HETATM 4016 O O   . HOH B 2 .   ? 11.30458  -34.09048 -20.53128 1.000 34.96712 ? 906 HOH A O   1 
HETATM 4017 O O   . HOH B 2 .   ? -7.72318  -16.13639 -18.96454 1.000 30.34384 ? 907 HOH A O   1 
HETATM 4018 O O   . HOH B 2 .   ? 14.49304  -17.41428 -33.21114 1.000 28.67607 ? 908 HOH A O   1 
HETATM 4019 O O   . HOH B 2 .   ? 31.193    4.038     -37.219   1.000 23.23076 ? 909 HOH A O   1 
HETATM 4020 O O   . HOH B 2 .   ? 23.04211  1.53740   -39.32687 1.000 36.60228 ? 910 HOH A O   1 
HETATM 4021 O O   . HOH B 2 .   ? -0.881    -23.040   -16.199   1.000 26.74725 ? 911 HOH A O   1 
HETATM 4022 O O   A HOH B 2 .   ? 10.03556  -6.10755  -11.91049 0.619 23.36205 ? 912 HOH A O   1 
HETATM 4023 O O   B HOH B 2 .   ? 10.86792  -5.23296  -13.05750 0.381 21.45046 ? 912 HOH A O   1 
HETATM 4024 O O   . HOH B 2 .   ? 14.92078  -6.63994  5.80917   1.000 20.67545 ? 913 HOH A O   1 
HETATM 4025 O O   . HOH B 2 .   ? 21.36718  6.89869   1.52297   1.000 29.42026 ? 914 HOH A O   1 
HETATM 4026 O O   . HOH B 2 .   ? 34.32458  -0.28871  -33.83980 1.000 28.74923 ? 915 HOH A O   1 
HETATM 4027 O O   . HOH B 2 .   ? -3.25405  3.89801   -20.23911 1.000 24.58062 ? 916 HOH A O   1 
HETATM 4028 O O   . HOH B 2 .   ? -3.42176  -7.08997  -12.12741 1.000 33.25563 ? 917 HOH A O   1 
HETATM 4029 O O   . HOH B 2 .   ? 36.06274  3.49728   -15.41232 1.000 33.78363 ? 918 HOH A O   1 
HETATM 4030 O O   . HOH B 2 .   ? 27.71772  -2.97792  -38.70352 1.000 35.32406 ? 919 HOH A O   1 
HETATM 4031 O O   . HOH B 2 .   ? 17.108    -30.446   -26.325   1.000 28.35552 ? 920 HOH A O   1 
HETATM 4032 O O   . HOH B 2 .   ? 16.35543  -15.25527 -32.93909 1.000 24.38356 ? 921 HOH A O   1 
HETATM 4033 O O   . HOH B 2 .   ? -2.98154  -2.63490  -11.16936 1.000 41.29302 ? 922 HOH A O   1 
HETATM 4034 O O   A HOH B 2 .   ? 16.51109  -2.98126  -15.94037 0.592 15.49323 ? 923 HOH A O   1 
HETATM 4035 O O   B HOH B 2 .   ? 16.29235  -1.96073  -13.74936 0.408 20.87751 ? 923 HOH A O   1 
HETATM 4036 O O   . HOH B 2 .   ? 20.54418  -3.21244  -19.31222 1.000 17.96916 ? 924 HOH A O   1 
HETATM 4037 O O   . HOH B 2 .   ? 25.12868  5.26768   -29.03143 1.000 14.04789 ? 925 HOH A O   1 
HETATM 4038 O O   . HOH B 2 .   ? 30.321    -0.190    3.341     1.000 17.87238 ? 926 HOH A O   1 
HETATM 4039 O O   . HOH B 2 .   ? 37.16804  -4.15616  -12.99466 1.000 35.93929 ? 927 HOH A O   1 
HETATM 4040 O O   . HOH B 2 .   ? 35.97349  -6.35118  -30.56911 1.000 35.36068 ? 928 HOH A O   1 
HETATM 4041 O O   . HOH B 2 .   ? 5.11537   -6.76423  -1.84568  1.000 47.77590 ? 929 HOH A O   1 
HETATM 4042 O O   . HOH B 2 .   ? 7.50345   -23.91225 -20.72337 1.000 31.32098 ? 930 HOH A O   1 
HETATM 4043 O O   . HOH B 2 .   ? 18.78817  2.63406   -40.86844 1.000 35.27948 ? 931 HOH A O   1 
HETATM 4044 O O   . HOH B 2 .   ? -4.77147  -2.62076  -14.60216 1.000 28.27431 ? 932 HOH A O   1 
HETATM 4045 O O   . HOH B 2 .   ? 35.22783  3.90473   -8.91729  1.000 30.21857 ? 933 HOH A O   1 
HETATM 4046 O O   . HOH B 2 .   ? 13.987    -35.207   -21.766   1.000 21.70491 ? 934 HOH A O   1 
HETATM 4047 O O   . HOH B 2 .   ? 15.399    -33.664   -24.062   1.000 29.28908 ? 935 HOH A O   1 
HETATM 4048 O O   . HOH B 2 .   ? 36.049    -2.484    -5.680    1.000 25.01888 ? 936 HOH A O   1 
HETATM 4049 O O   A HOH B 2 .   ? 13.87756  -3.86467  -14.98971 0.431 14.98058 ? 937 HOH A O   1 
HETATM 4050 O O   B HOH B 2 .   ? 12.69379  -3.72203  -13.68349 0.569 25.27168 ? 937 HOH A O   1 
HETATM 4051 O O   . HOH B 2 .   ? -0.61427  -10.64133 -35.99080 1.000 46.62447 ? 938 HOH A O   1 
HETATM 4052 O O   . HOH B 2 .   ? -3.12009  -19.64365 -16.24766 1.000 24.69460 ? 939 HOH A O   1 
HETATM 4053 O O   . HOH B 2 .   ? 8.75050   -29.20003 3.69444   1.000 17.01949 ? 940 HOH A O   1 
HETATM 4054 O O   . HOH B 2 .   ? 36.80363  -12.95676 -30.60980 1.000 25.72802 ? 941 HOH A O   1 
HETATM 4055 O O   . HOH B 2 .   ? 0.67983   6.81606   -30.44769 1.000 39.31211 ? 942 HOH A O   1 
HETATM 4056 O O   . HOH B 2 .   ? 10.11133  -18.21775 -33.26986 1.000 29.34860 ? 943 HOH A O   1 
HETATM 4057 O O   A HOH B 2 .   ? 41.978    -15.463   -7.241    0.544 30.83768 ? 944 HOH A O   1 
HETATM 4058 O O   B HOH B 2 .   ? 41.371    -16.653   -6.879    0.456 20.64050 ? 944 HOH A O   1 
HETATM 4059 O O   . HOH B 2 .   ? -3.99518  5.27536   -17.82384 1.000 30.99572 ? 945 HOH A O   1 
HETATM 4060 O O   . HOH B 2 .   ? 11.83699  -20.36223 -31.61948 1.000 24.33463 ? 946 HOH A O   1 
HETATM 4061 O O   . HOH B 2 .   ? 34.70741  -9.54299  -31.53266 1.000 25.91335 ? 947 HOH A O   1 
HETATM 4062 O O   . HOH B 2 .   ? 10.92311  -32.87368 2.02670   1.000 42.42362 ? 948 HOH A O   1 
HETATM 4063 O O   . HOH B 2 .   ? 28.84289  -25.94732 -1.50079  1.000 31.64683 ? 949 HOH A O   1 
HETATM 4064 O O   . HOH B 2 .   ? 34.53531  -18.10336 -30.66361 1.000 27.01490 ? 950 HOH A O   1 
HETATM 4065 O O   . HOH B 2 .   ? 37.25909  0.95899   -14.90188 1.000 33.77819 ? 951 HOH A O   1 
HETATM 4066 O O   . HOH B 2 .   ? 5.77120   -20.61673 -25.23530 1.000 23.03300 ? 952 HOH A O   1 
HETATM 4067 O O   . HOH B 2 .   ? 22.92317  -0.49088  -41.84200 1.000 39.15193 ? 953 HOH A O   1 
HETATM 4068 O O   . HOH B 2 .   ? 27.28113  -25.56037 2.39190   1.000 35.58639 ? 954 HOH A O   1 
HETATM 4069 O O   . HOH B 2 .   ? 19.28268  -31.28812 0.02334   1.000 33.67636 ? 955 HOH A O   1 
HETATM 4070 O O   . HOH B 2 .   ? 30.24217  2.57912   2.38148   1.000 31.16988 ? 956 HOH A O   1 
HETATM 4071 O O   . HOH B 2 .   ? 34.69735  -5.53316  -33.60438 1.000 34.54141 ? 957 HOH A O   1 
HETATM 4072 O O   . HOH B 2 .   ? 38.39646  -14.78948 -29.95343 1.000 33.92821 ? 958 HOH A O   1 
HETATM 4073 O O   . HOH B 2 .   ? 0.91452   -25.02956 -15.32004 1.000 27.49150 ? 959 HOH A O   1 
HETATM 4074 O O   . HOH B 2 .   ? 10.48862  -6.91756  5.81374   1.000 28.99448 ? 960 HOH A O   1 
HETATM 4075 O O   . HOH B 2 .   ? -3.00262  8.89601   -15.33284 1.000 37.73871 ? 961 HOH A O   1 
# 
