data_8WWG
# 
_entry.id   8WWG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8WWG         pdb_00008wwg 10.2210/pdb8wwg/pdb 
WWPDB D_1300042148 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.journal_volume'          
7  2 'Structure model' '_citation.page_first'              
8  2 'Structure model' '_citation.page_last'               
9  2 'Structure model' '_citation.pdbx_database_id_DOI'    
10 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 2 'Structure model' '_citation.title'                   
12 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8WWG 
_pdbx_database_status.recvd_initial_deposition_date   2023-10-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 hhge@ahu.edu.cn Honghua Ge ? 'principal investigator/group leader' 0000-0001-7176-6853 
4 jmma@ahu.edu.cn Jinming Ma ? 'principal investigator/group leader' 0000-0002-3199-9860 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Gao, Y.S.'  1 0009-0005-6639-4713 
'Xie, R.'    2 ?                   
'Chen, Y.N.' 3 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            270 
_citation.language                  ? 
_citation.page_first                132289 
_citation.page_last                 132289 
_citation.title                     
'Structural basis for substrate recognition by a S-adenosylhomocysteine hydrolase Lpg2021 from Legionella pneumophila.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2024.132289 
_citation.pdbx_database_id_PubMed   38735607 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gao, Y.'  1  ? 
primary 'Xie, R.'  2  ? 
primary 'Chen, Y.' 3  ? 
primary 'Yang, B.' 4  ? 
primary 'Wang, M.' 5  ? 
primary 'Hua, L.'  6  ? 
primary 'Wang, X.' 7  ? 
primary 'Wang, W.' 8  ? 
primary 'Wang, N.' 9  ? 
primary 'Ge, H.'   10 ? 
primary 'Ma, J.'   11 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Adenosylhomocysteinase            48372.074 1   ? ? ? ? 
2 non-polymer syn 'SULFATE ION'                     96.063    1   ? ? ? ? 
3 non-polymer syn NICOTINAMIDE-ADENINE-DINUCLEOTIDE 663.425   1   ? ? ? ? 
4 water       nat water                             18.015    287 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGHHHHHHHHQDYKVAEISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVALGAEV
RWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQVVHQKHPKLLTAIKGV
SEETTTGVARLYEMAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCAQALR
GQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQSLKQ
YQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLDEKVA
RLHLGRIGAKLTQLSNEQADYIGVDKNGPYKPDHYRY
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGHHHHHHHHQDYKVAEISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVALGAEV
RWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQVVHQKHPKLLTAIKGV
SEETTTGVARLYEMAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCAQALR
GQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQSLKQ
YQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLDEKVA
RLHLGRIGAKLTQLSNEQADYIGVDKNGPYKPDHYRY
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'SULFATE ION'                     SO4 
3 NICOTINAMIDE-ADENINE-DINUCLEOTIDE NAD 
4 water                             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  GLN n 
1 12  ASP n 
1 13  TYR n 
1 14  LYS n 
1 15  VAL n 
1 16  ALA n 
1 17  GLU n 
1 18  ILE n 
1 19  SER n 
1 20  LEU n 
1 21  ALA n 
1 22  ASP n 
1 23  TRP n 
1 24  GLY n 
1 25  ARG n 
1 26  LYS n 
1 27  GLU n 
1 28  ILE n 
1 29  ALA n 
1 30  ILE n 
1 31  ALA n 
1 32  GLU n 
1 33  THR n 
1 34  GLU n 
1 35  MET n 
1 36  PRO n 
1 37  GLY n 
1 38  LEU n 
1 39  MET n 
1 40  ALA n 
1 41  LEU n 
1 42  ARG n 
1 43  GLU n 
1 44  GLU n 
1 45  PHE n 
1 46  SER n 
1 47  ALA n 
1 48  LYS n 
1 49  LYS n 
1 50  PRO n 
1 51  LEU n 
1 52  GLN n 
1 53  GLY n 
1 54  ALA n 
1 55  ARG n 
1 56  ILE n 
1 57  ALA n 
1 58  GLY n 
1 59  CYS n 
1 60  LEU n 
1 61  HIS n 
1 62  MET n 
1 63  THR n 
1 64  ILE n 
1 65  GLN n 
1 66  THR n 
1 67  ALA n 
1 68  VAL n 
1 69  LEU n 
1 70  ILE n 
1 71  GLU n 
1 72  THR n 
1 73  LEU n 
1 74  VAL n 
1 75  ALA n 
1 76  LEU n 
1 77  GLY n 
1 78  ALA n 
1 79  GLU n 
1 80  VAL n 
1 81  ARG n 
1 82  TRP n 
1 83  SER n 
1 84  SER n 
1 85  CYS n 
1 86  ASN n 
1 87  ILE n 
1 88  PHE n 
1 89  SER n 
1 90  THR n 
1 91  GLN n 
1 92  ASP n 
1 93  HIS n 
1 94  ALA n 
1 95  ALA n 
1 96  SER n 
1 97  ALA n 
1 98  ILE n 
1 99  ALA n 
1 100 ALA n 
1 101 LYS n 
1 102 GLY n 
1 103 ILE n 
1 104 PRO n 
1 105 VAL n 
1 106 PHE n 
1 107 ALA n 
1 108 TRP n 
1 109 LYS n 
1 110 GLY n 
1 111 GLU n 
1 112 THR n 
1 113 GLU n 
1 114 GLU n 
1 115 GLU n 
1 116 TYR n 
1 117 TRP n 
1 118 TRP n 
1 119 CYS n 
1 120 VAL n 
1 121 GLU n 
1 122 GLN n 
1 123 THR n 
1 124 LEU n 
1 125 SER n 
1 126 GLY n 
1 127 PRO n 
1 128 ASN n 
1 129 GLY n 
1 130 TRP n 
1 131 THR n 
1 132 PRO n 
1 133 ASN n 
1 134 LEU n 
1 135 LEU n 
1 136 LEU n 
1 137 ASP n 
1 138 ASP n 
1 139 GLY n 
1 140 GLY n 
1 141 ASP n 
1 142 LEU n 
1 143 THR n 
1 144 GLN n 
1 145 VAL n 
1 146 VAL n 
1 147 HIS n 
1 148 GLN n 
1 149 LYS n 
1 150 HIS n 
1 151 PRO n 
1 152 LYS n 
1 153 LEU n 
1 154 LEU n 
1 155 THR n 
1 156 ALA n 
1 157 ILE n 
1 158 LYS n 
1 159 GLY n 
1 160 VAL n 
1 161 SER n 
1 162 GLU n 
1 163 GLU n 
1 164 THR n 
1 165 THR n 
1 166 THR n 
1 167 GLY n 
1 168 VAL n 
1 169 ALA n 
1 170 ARG n 
1 171 LEU n 
1 172 TYR n 
1 173 GLU n 
1 174 MET n 
1 175 ALA n 
1 176 LYS n 
1 177 HIS n 
1 178 GLY n 
1 179 GLN n 
1 180 LEU n 
1 181 LYS n 
1 182 ILE n 
1 183 PRO n 
1 184 ALA n 
1 185 ILE n 
1 186 ASN n 
1 187 VAL n 
1 188 ASN n 
1 189 ASN n 
1 190 ALA n 
1 191 VAL n 
1 192 THR n 
1 193 LYS n 
1 194 SER n 
1 195 LYS n 
1 196 PHE n 
1 197 ASP n 
1 198 ASN n 
1 199 LEU n 
1 200 TYR n 
1 201 GLY n 
1 202 CYS n 
1 203 ARG n 
1 204 GLU n 
1 205 SER n 
1 206 LEU n 
1 207 LEU n 
1 208 ASP n 
1 209 GLY n 
1 210 LEU n 
1 211 LYS n 
1 212 ARG n 
1 213 ALA n 
1 214 THR n 
1 215 ASP n 
1 216 VAL n 
1 217 MET n 
1 218 ILE n 
1 219 ALA n 
1 220 GLY n 
1 221 LYS n 
1 222 VAL n 
1 223 ALA n 
1 224 LEU n 
1 225 ILE n 
1 226 LEU n 
1 227 GLY n 
1 228 TYR n 
1 229 GLY n 
1 230 ASP n 
1 231 VAL n 
1 232 GLY n 
1 233 LYS n 
1 234 GLY n 
1 235 CYS n 
1 236 ALA n 
1 237 GLN n 
1 238 ALA n 
1 239 LEU n 
1 240 ARG n 
1 241 GLY n 
1 242 GLN n 
1 243 GLY n 
1 244 ALA n 
1 245 THR n 
1 246 VAL n 
1 247 LEU n 
1 248 VAL n 
1 249 ALA n 
1 250 GLU n 
1 251 ILE n 
1 252 ASP n 
1 253 PRO n 
1 254 ILE n 
1 255 CYS n 
1 256 ALA n 
1 257 LEU n 
1 258 GLN n 
1 259 ALA n 
1 260 ALA n 
1 261 MET n 
1 262 GLU n 
1 263 GLY n 
1 264 TYR n 
1 265 ARG n 
1 266 VAL n 
1 267 VAL n 
1 268 THR n 
1 269 LEU n 
1 270 ASP n 
1 271 ASP n 
1 272 VAL n 
1 273 ALA n 
1 274 GLU n 
1 275 GLN n 
1 276 VAL n 
1 277 ASP n 
1 278 ILE n 
1 279 VAL n 
1 280 VAL n 
1 281 THR n 
1 282 ALA n 
1 283 THR n 
1 284 GLY n 
1 285 ASN n 
1 286 TYR n 
1 287 HIS n 
1 288 VAL n 
1 289 VAL n 
1 290 THR n 
1 291 HIS n 
1 292 ASP n 
1 293 HIS n 
1 294 MET n 
1 295 LYS n 
1 296 ARG n 
1 297 MET n 
1 298 ARG n 
1 299 ASN n 
1 300 GLN n 
1 301 ALA n 
1 302 ILE n 
1 303 LEU n 
1 304 CYS n 
1 305 ASN n 
1 306 ILE n 
1 307 GLY n 
1 308 HIS n 
1 309 PHE n 
1 310 ASP n 
1 311 SER n 
1 312 GLU n 
1 313 ILE n 
1 314 ASP n 
1 315 ILE n 
1 316 GLN n 
1 317 SER n 
1 318 LEU n 
1 319 LYS n 
1 320 GLN n 
1 321 TYR n 
1 322 GLN n 
1 323 TRP n 
1 324 GLU n 
1 325 ASN n 
1 326 ILE n 
1 327 LYS n 
1 328 PRO n 
1 329 GLN n 
1 330 VAL n 
1 331 ASP n 
1 332 HIS n 
1 333 VAL n 
1 334 ILE n 
1 335 PHE n 
1 336 PRO n 
1 337 ASP n 
1 338 GLY n 
1 339 LYS n 
1 340 ARG n 
1 341 ILE n 
1 342 ILE n 
1 343 ILE n 
1 344 LEU n 
1 345 ALA n 
1 346 GLU n 
1 347 GLY n 
1 348 ARG n 
1 349 LEU n 
1 350 VAL n 
1 351 ASN n 
1 352 LEU n 
1 353 GLY n 
1 354 CYS n 
1 355 ALA n 
1 356 THR n 
1 357 GLY n 
1 358 HIS n 
1 359 PRO n 
1 360 SER n 
1 361 PHE n 
1 362 VAL n 
1 363 MET n 
1 364 SER n 
1 365 ALA n 
1 366 SER n 
1 367 PHE n 
1 368 THR n 
1 369 ASN n 
1 370 GLN n 
1 371 VAL n 
1 372 LEU n 
1 373 ALA n 
1 374 GLN n 
1 375 ILE n 
1 376 GLU n 
1 377 LEU n 
1 378 PHE n 
1 379 GLN n 
1 380 ASN n 
1 381 SER n 
1 382 SER n 
1 383 GLN n 
1 384 TYR n 
1 385 GLN n 
1 386 ASN n 
1 387 GLN n 
1 388 VAL n 
1 389 TYR n 
1 390 VAL n 
1 391 LEU n 
1 392 PRO n 
1 393 LYS n 
1 394 VAL n 
1 395 LEU n 
1 396 ASP n 
1 397 GLU n 
1 398 LYS n 
1 399 VAL n 
1 400 ALA n 
1 401 ARG n 
1 402 LEU n 
1 403 HIS n 
1 404 LEU n 
1 405 GLY n 
1 406 ARG n 
1 407 ILE n 
1 408 GLY n 
1 409 ALA n 
1 410 LYS n 
1 411 LEU n 
1 412 THR n 
1 413 GLN n 
1 414 LEU n 
1 415 SER n 
1 416 ASN n 
1 417 GLU n 
1 418 GLN n 
1 419 ALA n 
1 420 ASP n 
1 421 TYR n 
1 422 ILE n 
1 423 GLY n 
1 424 VAL n 
1 425 ASP n 
1 426 LYS n 
1 427 ASN n 
1 428 GLY n 
1 429 PRO n 
1 430 TYR n 
1 431 LYS n 
1 432 PRO n 
1 433 ASP n 
1 434 HIS n 
1 435 TYR n 
1 436 ARG n 
1 437 TYR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   437 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ahcY 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Legionella pneumophila' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     446 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                           ? 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                          ? 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                        ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                   ? 'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE                          ? 'C3 H7 N O2 S'      121.158 
GLN 'L-peptide linking' y GLUTAMINE                         ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                   ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                           ? 'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                         ? 'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                             ? 'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                        ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                           ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                            ? 'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                        ? 'C5 H11 N O2 S'     149.211 
NAD non-polymer         . NICOTINAMIDE-ADENINE-DINUCLEOTIDE ? 'C21 H27 N7 O14 P2' 663.425 
PHE 'L-peptide linking' y PHENYLALANINE                     ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                           ? 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                            ? 'C3 H7 N O3'        105.093 
SO4 non-polymer         . 'SULFATE ION'                     ? 'O4 S -2'           96.063  
THR 'L-peptide linking' y THREONINE                         ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                        ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                          ? 'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                            ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   5   ?   ?   ?   A . n 
A 1 2   GLY 2   6   ?   ?   ?   A . n 
A 1 3   HIS 3   7   ?   ?   ?   A . n 
A 1 4   HIS 4   8   ?   ?   ?   A . n 
A 1 5   HIS 5   9   ?   ?   ?   A . n 
A 1 6   HIS 6   10  ?   ?   ?   A . n 
A 1 7   HIS 7   11  ?   ?   ?   A . n 
A 1 8   HIS 8   12  ?   ?   ?   A . n 
A 1 9   HIS 9   13  ?   ?   ?   A . n 
A 1 10  HIS 10  14  ?   ?   ?   A . n 
A 1 11  GLN 11  15  15  GLN GLN A . n 
A 1 12  ASP 12  16  16  ASP ASP A . n 
A 1 13  TYR 13  17  17  TYR TYR A . n 
A 1 14  LYS 14  18  18  LYS LYS A . n 
A 1 15  VAL 15  19  19  VAL VAL A . n 
A 1 16  ALA 16  20  20  ALA ALA A . n 
A 1 17  GLU 17  21  21  GLU GLU A . n 
A 1 18  ILE 18  22  22  ILE ILE A . n 
A 1 19  SER 19  23  23  SER SER A . n 
A 1 20  LEU 20  24  24  LEU LEU A . n 
A 1 21  ALA 21  25  25  ALA ALA A . n 
A 1 22  ASP 22  26  26  ASP ASP A . n 
A 1 23  TRP 23  27  27  TRP TRP A . n 
A 1 24  GLY 24  28  28  GLY GLY A . n 
A 1 25  ARG 25  29  29  ARG ARG A . n 
A 1 26  LYS 26  30  30  LYS LYS A . n 
A 1 27  GLU 27  31  31  GLU GLU A . n 
A 1 28  ILE 28  32  32  ILE ILE A . n 
A 1 29  ALA 29  33  33  ALA ALA A . n 
A 1 30  ILE 30  34  34  ILE ILE A . n 
A 1 31  ALA 31  35  35  ALA ALA A . n 
A 1 32  GLU 32  36  36  GLU GLU A . n 
A 1 33  THR 33  37  37  THR THR A . n 
A 1 34  GLU 34  38  38  GLU GLU A . n 
A 1 35  MET 35  39  39  MET MET A . n 
A 1 36  PRO 36  40  40  PRO PRO A . n 
A 1 37  GLY 37  41  41  GLY GLY A . n 
A 1 38  LEU 38  42  42  LEU LEU A . n 
A 1 39  MET 39  43  43  MET MET A . n 
A 1 40  ALA 40  44  44  ALA ALA A . n 
A 1 41  LEU 41  45  45  LEU LEU A . n 
A 1 42  ARG 42  46  46  ARG ARG A . n 
A 1 43  GLU 43  47  47  GLU GLU A . n 
A 1 44  GLU 44  48  48  GLU GLU A . n 
A 1 45  PHE 45  49  49  PHE PHE A . n 
A 1 46  SER 46  50  50  SER SER A . n 
A 1 47  ALA 47  51  51  ALA ALA A . n 
A 1 48  LYS 48  52  52  LYS LYS A . n 
A 1 49  LYS 49  53  53  LYS LYS A . n 
A 1 50  PRO 50  54  54  PRO PRO A . n 
A 1 51  LEU 51  55  55  LEU LEU A . n 
A 1 52  GLN 52  56  56  GLN GLN A . n 
A 1 53  GLY 53  57  57  GLY GLY A . n 
A 1 54  ALA 54  58  58  ALA ALA A . n 
A 1 55  ARG 55  59  59  ARG ARG A . n 
A 1 56  ILE 56  60  60  ILE ILE A . n 
A 1 57  ALA 57  61  61  ALA ALA A . n 
A 1 58  GLY 58  62  62  GLY GLY A . n 
A 1 59  CYS 59  63  63  CYS CYS A . n 
A 1 60  LEU 60  64  64  LEU LEU A . n 
A 1 61  HIS 61  65  65  HIS HIS A . n 
A 1 62  MET 62  66  66  MET MET A . n 
A 1 63  THR 63  67  67  THR THR A . n 
A 1 64  ILE 64  68  68  ILE ILE A . n 
A 1 65  GLN 65  69  69  GLN GLN A . n 
A 1 66  THR 66  70  70  THR THR A . n 
A 1 67  ALA 67  71  71  ALA ALA A . n 
A 1 68  VAL 68  72  72  VAL VAL A . n 
A 1 69  LEU 69  73  73  LEU LEU A . n 
A 1 70  ILE 70  74  74  ILE ILE A . n 
A 1 71  GLU 71  75  75  GLU GLU A . n 
A 1 72  THR 72  76  76  THR THR A . n 
A 1 73  LEU 73  77  77  LEU LEU A . n 
A 1 74  VAL 74  78  78  VAL VAL A . n 
A 1 75  ALA 75  79  79  ALA ALA A . n 
A 1 76  LEU 76  80  80  LEU LEU A . n 
A 1 77  GLY 77  81  81  GLY GLY A . n 
A 1 78  ALA 78  82  82  ALA ALA A . n 
A 1 79  GLU 79  83  83  GLU GLU A . n 
A 1 80  VAL 80  84  84  VAL VAL A . n 
A 1 81  ARG 81  85  85  ARG ARG A . n 
A 1 82  TRP 82  86  86  TRP TRP A . n 
A 1 83  SER 83  87  87  SER SER A . n 
A 1 84  SER 84  88  88  SER SER A . n 
A 1 85  CYS 85  89  89  CYS CYS A . n 
A 1 86  ASN 86  90  90  ASN ASN A . n 
A 1 87  ILE 87  91  91  ILE ILE A . n 
A 1 88  PHE 88  92  92  PHE PHE A . n 
A 1 89  SER 89  93  93  SER SER A . n 
A 1 90  THR 90  94  94  THR THR A . n 
A 1 91  GLN 91  95  95  GLN GLN A . n 
A 1 92  ASP 92  96  96  ASP ASP A . n 
A 1 93  HIS 93  97  97  HIS HIS A . n 
A 1 94  ALA 94  98  98  ALA ALA A . n 
A 1 95  ALA 95  99  99  ALA ALA A . n 
A 1 96  SER 96  100 100 SER SER A . n 
A 1 97  ALA 97  101 101 ALA ALA A . n 
A 1 98  ILE 98  102 102 ILE ILE A . n 
A 1 99  ALA 99  103 103 ALA ALA A . n 
A 1 100 ALA 100 104 104 ALA ALA A . n 
A 1 101 LYS 101 105 105 LYS LYS A . n 
A 1 102 GLY 102 106 106 GLY GLY A . n 
A 1 103 ILE 103 107 107 ILE ILE A . n 
A 1 104 PRO 104 108 108 PRO PRO A . n 
A 1 105 VAL 105 109 109 VAL VAL A . n 
A 1 106 PHE 106 110 110 PHE PHE A . n 
A 1 107 ALA 107 111 111 ALA ALA A . n 
A 1 108 TRP 108 112 112 TRP TRP A . n 
A 1 109 LYS 109 113 113 LYS LYS A . n 
A 1 110 GLY 110 114 114 GLY GLY A . n 
A 1 111 GLU 111 115 115 GLU GLU A . n 
A 1 112 THR 112 116 116 THR THR A . n 
A 1 113 GLU 113 117 117 GLU GLU A . n 
A 1 114 GLU 114 118 118 GLU GLU A . n 
A 1 115 GLU 115 119 119 GLU GLU A . n 
A 1 116 TYR 116 120 120 TYR TYR A . n 
A 1 117 TRP 117 121 121 TRP TRP A . n 
A 1 118 TRP 118 122 122 TRP TRP A . n 
A 1 119 CYS 119 123 123 CYS CYS A . n 
A 1 120 VAL 120 124 124 VAL VAL A . n 
A 1 121 GLU 121 125 125 GLU GLU A . n 
A 1 122 GLN 122 126 126 GLN GLN A . n 
A 1 123 THR 123 127 127 THR THR A . n 
A 1 124 LEU 124 128 128 LEU LEU A . n 
A 1 125 SER 125 129 129 SER SER A . n 
A 1 126 GLY 126 130 130 GLY GLY A . n 
A 1 127 PRO 127 131 131 PRO PRO A . n 
A 1 128 ASN 128 132 132 ASN ASN A . n 
A 1 129 GLY 129 133 133 GLY GLY A . n 
A 1 130 TRP 130 134 134 TRP TRP A . n 
A 1 131 THR 131 135 135 THR THR A . n 
A 1 132 PRO 132 136 136 PRO PRO A . n 
A 1 133 ASN 133 137 137 ASN ASN A . n 
A 1 134 LEU 134 138 138 LEU LEU A . n 
A 1 135 LEU 135 139 139 LEU LEU A . n 
A 1 136 LEU 136 140 140 LEU LEU A . n 
A 1 137 ASP 137 141 141 ASP ASP A . n 
A 1 138 ASP 138 142 142 ASP ASP A . n 
A 1 139 GLY 139 143 143 GLY GLY A . n 
A 1 140 GLY 140 144 144 GLY GLY A . n 
A 1 141 ASP 141 145 145 ASP ASP A . n 
A 1 142 LEU 142 146 146 LEU LEU A . n 
A 1 143 THR 143 147 147 THR THR A . n 
A 1 144 GLN 144 148 148 GLN GLN A . n 
A 1 145 VAL 145 149 149 VAL VAL A . n 
A 1 146 VAL 146 150 150 VAL VAL A . n 
A 1 147 HIS 147 151 151 HIS HIS A . n 
A 1 148 GLN 148 152 152 GLN GLN A . n 
A 1 149 LYS 149 153 153 LYS LYS A . n 
A 1 150 HIS 150 154 154 HIS HIS A . n 
A 1 151 PRO 151 155 155 PRO PRO A . n 
A 1 152 LYS 152 156 156 LYS LYS A . n 
A 1 153 LEU 153 157 157 LEU LEU A . n 
A 1 154 LEU 154 158 158 LEU LEU A . n 
A 1 155 THR 155 159 159 THR THR A . n 
A 1 156 ALA 156 160 160 ALA ALA A . n 
A 1 157 ILE 157 161 161 ILE ILE A . n 
A 1 158 LYS 158 162 162 LYS LYS A . n 
A 1 159 GLY 159 163 163 GLY GLY A . n 
A 1 160 VAL 160 164 164 VAL VAL A . n 
A 1 161 SER 161 165 165 SER SER A . n 
A 1 162 GLU 162 166 166 GLU GLU A . n 
A 1 163 GLU 163 167 167 GLU GLU A . n 
A 1 164 THR 164 168 168 THR THR A . n 
A 1 165 THR 165 169 169 THR THR A . n 
A 1 166 THR 166 170 170 THR THR A . n 
A 1 167 GLY 167 171 171 GLY GLY A . n 
A 1 168 VAL 168 172 172 VAL VAL A . n 
A 1 169 ALA 169 173 173 ALA ALA A . n 
A 1 170 ARG 170 174 174 ARG ARG A . n 
A 1 171 LEU 171 175 175 LEU LEU A . n 
A 1 172 TYR 172 176 176 TYR TYR A . n 
A 1 173 GLU 173 177 177 GLU GLU A . n 
A 1 174 MET 174 178 178 MET MET A . n 
A 1 175 ALA 175 179 179 ALA ALA A . n 
A 1 176 LYS 176 180 180 LYS LYS A . n 
A 1 177 HIS 177 181 181 HIS HIS A . n 
A 1 178 GLY 178 182 182 GLY GLY A . n 
A 1 179 GLN 179 183 183 GLN GLN A . n 
A 1 180 LEU 180 184 184 LEU LEU A . n 
A 1 181 LYS 181 185 185 LYS LYS A . n 
A 1 182 ILE 182 186 186 ILE ILE A . n 
A 1 183 PRO 183 187 187 PRO PRO A . n 
A 1 184 ALA 184 188 188 ALA ALA A . n 
A 1 185 ILE 185 189 189 ILE ILE A . n 
A 1 186 ASN 186 190 190 ASN ASN A . n 
A 1 187 VAL 187 191 191 VAL VAL A . n 
A 1 188 ASN 188 192 192 ASN ASN A . n 
A 1 189 ASN 189 193 193 ASN ASN A . n 
A 1 190 ALA 190 194 194 ALA ALA A . n 
A 1 191 VAL 191 195 195 VAL VAL A . n 
A 1 192 THR 192 196 196 THR THR A . n 
A 1 193 LYS 193 197 197 LYS LYS A . n 
A 1 194 SER 194 198 198 SER SER A . n 
A 1 195 LYS 195 199 199 LYS LYS A . n 
A 1 196 PHE 196 200 200 PHE PHE A . n 
A 1 197 ASP 197 201 201 ASP ASP A . n 
A 1 198 ASN 198 202 202 ASN ASN A . n 
A 1 199 LEU 199 203 203 LEU LEU A . n 
A 1 200 TYR 200 204 204 TYR TYR A . n 
A 1 201 GLY 201 205 205 GLY GLY A . n 
A 1 202 CYS 202 206 206 CYS CYS A . n 
A 1 203 ARG 203 207 207 ARG ARG A . n 
A 1 204 GLU 204 208 208 GLU GLU A . n 
A 1 205 SER 205 209 209 SER SER A . n 
A 1 206 LEU 206 210 210 LEU LEU A . n 
A 1 207 LEU 207 211 211 LEU LEU A . n 
A 1 208 ASP 208 212 212 ASP ASP A . n 
A 1 209 GLY 209 213 213 GLY GLY A . n 
A 1 210 LEU 210 214 214 LEU LEU A . n 
A 1 211 LYS 211 215 215 LYS LYS A . n 
A 1 212 ARG 212 216 216 ARG ARG A . n 
A 1 213 ALA 213 217 217 ALA ALA A . n 
A 1 214 THR 214 218 218 THR THR A . n 
A 1 215 ASP 215 219 219 ASP ASP A . n 
A 1 216 VAL 216 220 220 VAL VAL A . n 
A 1 217 MET 217 221 221 MET MET A . n 
A 1 218 ILE 218 222 222 ILE ILE A . n 
A 1 219 ALA 219 223 223 ALA ALA A . n 
A 1 220 GLY 220 224 224 GLY GLY A . n 
A 1 221 LYS 221 225 225 LYS LYS A . n 
A 1 222 VAL 222 226 226 VAL VAL A . n 
A 1 223 ALA 223 227 227 ALA ALA A . n 
A 1 224 LEU 224 228 228 LEU LEU A . n 
A 1 225 ILE 225 229 229 ILE ILE A . n 
A 1 226 LEU 226 230 230 LEU LEU A . n 
A 1 227 GLY 227 231 231 GLY GLY A . n 
A 1 228 TYR 228 232 232 TYR TYR A . n 
A 1 229 GLY 229 233 233 GLY GLY A . n 
A 1 230 ASP 230 234 234 ASP ASP A . n 
A 1 231 VAL 231 235 235 VAL VAL A . n 
A 1 232 GLY 232 236 236 GLY GLY A . n 
A 1 233 LYS 233 237 237 LYS LYS A . n 
A 1 234 GLY 234 238 238 GLY GLY A . n 
A 1 235 CYS 235 239 239 CYS CYS A . n 
A 1 236 ALA 236 240 240 ALA ALA A . n 
A 1 237 GLN 237 241 241 GLN GLN A . n 
A 1 238 ALA 238 242 242 ALA ALA A . n 
A 1 239 LEU 239 243 243 LEU LEU A . n 
A 1 240 ARG 240 244 244 ARG ARG A . n 
A 1 241 GLY 241 245 245 GLY GLY A . n 
A 1 242 GLN 242 246 246 GLN GLN A . n 
A 1 243 GLY 243 247 247 GLY GLY A . n 
A 1 244 ALA 244 248 248 ALA ALA A . n 
A 1 245 THR 245 249 249 THR THR A . n 
A 1 246 VAL 246 250 250 VAL VAL A . n 
A 1 247 LEU 247 251 251 LEU LEU A . n 
A 1 248 VAL 248 252 252 VAL VAL A . n 
A 1 249 ALA 249 253 253 ALA ALA A . n 
A 1 250 GLU 250 254 254 GLU GLU A . n 
A 1 251 ILE 251 255 255 ILE ILE A . n 
A 1 252 ASP 252 256 256 ASP ASP A . n 
A 1 253 PRO 253 257 257 PRO PRO A . n 
A 1 254 ILE 254 258 258 ILE ILE A . n 
A 1 255 CYS 255 259 259 CYS CYS A . n 
A 1 256 ALA 256 260 260 ALA ALA A . n 
A 1 257 LEU 257 261 261 LEU LEU A . n 
A 1 258 GLN 258 262 262 GLN GLN A . n 
A 1 259 ALA 259 263 263 ALA ALA A . n 
A 1 260 ALA 260 264 264 ALA ALA A . n 
A 1 261 MET 261 265 265 MET MET A . n 
A 1 262 GLU 262 266 266 GLU GLU A . n 
A 1 263 GLY 263 267 267 GLY GLY A . n 
A 1 264 TYR 264 268 268 TYR TYR A . n 
A 1 265 ARG 265 269 269 ARG ARG A . n 
A 1 266 VAL 266 270 270 VAL VAL A . n 
A 1 267 VAL 267 271 271 VAL VAL A . n 
A 1 268 THR 268 272 272 THR THR A . n 
A 1 269 LEU 269 273 273 LEU LEU A . n 
A 1 270 ASP 270 274 274 ASP ASP A . n 
A 1 271 ASP 271 275 275 ASP ASP A . n 
A 1 272 VAL 272 276 276 VAL VAL A . n 
A 1 273 ALA 273 277 277 ALA ALA A . n 
A 1 274 GLU 274 278 278 GLU GLU A . n 
A 1 275 GLN 275 279 279 GLN GLN A . n 
A 1 276 VAL 276 280 280 VAL VAL A . n 
A 1 277 ASP 277 281 281 ASP ASP A . n 
A 1 278 ILE 278 282 282 ILE ILE A . n 
A 1 279 VAL 279 283 283 VAL VAL A . n 
A 1 280 VAL 280 284 284 VAL VAL A . n 
A 1 281 THR 281 285 285 THR THR A . n 
A 1 282 ALA 282 286 286 ALA ALA A . n 
A 1 283 THR 283 287 287 THR THR A . n 
A 1 284 GLY 284 288 288 GLY GLY A . n 
A 1 285 ASN 285 289 289 ASN ASN A . n 
A 1 286 TYR 286 290 290 TYR TYR A . n 
A 1 287 HIS 287 291 291 HIS HIS A . n 
A 1 288 VAL 288 292 292 VAL VAL A . n 
A 1 289 VAL 289 293 293 VAL VAL A . n 
A 1 290 THR 290 294 294 THR THR A . n 
A 1 291 HIS 291 295 295 HIS HIS A . n 
A 1 292 ASP 292 296 296 ASP ASP A . n 
A 1 293 HIS 293 297 297 HIS HIS A . n 
A 1 294 MET 294 298 298 MET MET A . n 
A 1 295 LYS 295 299 299 LYS LYS A . n 
A 1 296 ARG 296 300 300 ARG ARG A . n 
A 1 297 MET 297 301 301 MET MET A . n 
A 1 298 ARG 298 302 302 ARG ARG A . n 
A 1 299 ASN 299 303 303 ASN ASN A . n 
A 1 300 GLN 300 304 304 GLN GLN A . n 
A 1 301 ALA 301 305 305 ALA ALA A . n 
A 1 302 ILE 302 306 306 ILE ILE A . n 
A 1 303 LEU 303 307 307 LEU LEU A . n 
A 1 304 CYS 304 308 308 CYS CYS A . n 
A 1 305 ASN 305 309 309 ASN ASN A . n 
A 1 306 ILE 306 310 310 ILE ILE A . n 
A 1 307 GLY 307 311 311 GLY GLY A . n 
A 1 308 HIS 308 312 312 HIS HIS A . n 
A 1 309 PHE 309 313 313 PHE PHE A . n 
A 1 310 ASP 310 314 314 ASP ASP A . n 
A 1 311 SER 311 315 315 SER SER A . n 
A 1 312 GLU 312 316 316 GLU GLU A . n 
A 1 313 ILE 313 317 317 ILE ILE A . n 
A 1 314 ASP 314 318 318 ASP ASP A . n 
A 1 315 ILE 315 319 319 ILE ILE A . n 
A 1 316 GLN 316 320 320 GLN GLN A . n 
A 1 317 SER 317 321 321 SER SER A . n 
A 1 318 LEU 318 322 322 LEU LEU A . n 
A 1 319 LYS 319 323 323 LYS LYS A . n 
A 1 320 GLN 320 324 324 GLN GLN A . n 
A 1 321 TYR 321 325 325 TYR TYR A . n 
A 1 322 GLN 322 326 326 GLN GLN A . n 
A 1 323 TRP 323 327 327 TRP TRP A . n 
A 1 324 GLU 324 328 328 GLU GLU A . n 
A 1 325 ASN 325 329 329 ASN ASN A . n 
A 1 326 ILE 326 330 330 ILE ILE A . n 
A 1 327 LYS 327 331 331 LYS LYS A . n 
A 1 328 PRO 328 332 332 PRO PRO A . n 
A 1 329 GLN 329 333 333 GLN GLN A . n 
A 1 330 VAL 330 334 334 VAL VAL A . n 
A 1 331 ASP 331 335 335 ASP ASP A . n 
A 1 332 HIS 332 336 336 HIS HIS A . n 
A 1 333 VAL 333 337 337 VAL VAL A . n 
A 1 334 ILE 334 338 338 ILE ILE A . n 
A 1 335 PHE 335 339 339 PHE PHE A . n 
A 1 336 PRO 336 340 340 PRO PRO A . n 
A 1 337 ASP 337 341 341 ASP ASP A . n 
A 1 338 GLY 338 342 342 GLY GLY A . n 
A 1 339 LYS 339 343 343 LYS LYS A . n 
A 1 340 ARG 340 344 344 ARG ARG A . n 
A 1 341 ILE 341 345 345 ILE ILE A . n 
A 1 342 ILE 342 346 346 ILE ILE A . n 
A 1 343 ILE 343 347 347 ILE ILE A . n 
A 1 344 LEU 344 348 348 LEU LEU A . n 
A 1 345 ALA 345 349 349 ALA ALA A . n 
A 1 346 GLU 346 350 350 GLU GLU A . n 
A 1 347 GLY 347 351 351 GLY GLY A . n 
A 1 348 ARG 348 352 352 ARG ARG A . n 
A 1 349 LEU 349 353 353 LEU LEU A . n 
A 1 350 VAL 350 354 354 VAL VAL A . n 
A 1 351 ASN 351 355 355 ASN ASN A . n 
A 1 352 LEU 352 356 356 LEU LEU A . n 
A 1 353 GLY 353 357 357 GLY GLY A . n 
A 1 354 CYS 354 358 358 CYS CYS A . n 
A 1 355 ALA 355 359 359 ALA ALA A . n 
A 1 356 THR 356 360 360 THR THR A . n 
A 1 357 GLY 357 361 361 GLY GLY A . n 
A 1 358 HIS 358 362 362 HIS HIS A . n 
A 1 359 PRO 359 363 363 PRO PRO A . n 
A 1 360 SER 360 364 364 SER SER A . n 
A 1 361 PHE 361 365 365 PHE PHE A . n 
A 1 362 VAL 362 366 366 VAL VAL A . n 
A 1 363 MET 363 367 367 MET MET A . n 
A 1 364 SER 364 368 368 SER SER A . n 
A 1 365 ALA 365 369 369 ALA ALA A . n 
A 1 366 SER 366 370 370 SER SER A . n 
A 1 367 PHE 367 371 371 PHE PHE A . n 
A 1 368 THR 368 372 372 THR THR A . n 
A 1 369 ASN 369 373 373 ASN ASN A . n 
A 1 370 GLN 370 374 374 GLN GLN A . n 
A 1 371 VAL 371 375 375 VAL VAL A . n 
A 1 372 LEU 372 376 376 LEU LEU A . n 
A 1 373 ALA 373 377 377 ALA ALA A . n 
A 1 374 GLN 374 378 378 GLN GLN A . n 
A 1 375 ILE 375 379 379 ILE ILE A . n 
A 1 376 GLU 376 380 380 GLU GLU A . n 
A 1 377 LEU 377 381 381 LEU LEU A . n 
A 1 378 PHE 378 382 382 PHE PHE A . n 
A 1 379 GLN 379 383 383 GLN GLN A . n 
A 1 380 ASN 380 384 384 ASN ASN A . n 
A 1 381 SER 381 385 385 SER SER A . n 
A 1 382 SER 382 386 386 SER SER A . n 
A 1 383 GLN 383 387 387 GLN GLN A . n 
A 1 384 TYR 384 388 388 TYR TYR A . n 
A 1 385 GLN 385 389 389 GLN GLN A . n 
A 1 386 ASN 386 390 390 ASN ASN A . n 
A 1 387 GLN 387 391 391 GLN GLN A . n 
A 1 388 VAL 388 392 392 VAL VAL A . n 
A 1 389 TYR 389 393 393 TYR TYR A . n 
A 1 390 VAL 390 394 394 VAL VAL A . n 
A 1 391 LEU 391 395 395 LEU LEU A . n 
A 1 392 PRO 392 396 396 PRO PRO A . n 
A 1 393 LYS 393 397 397 LYS LYS A . n 
A 1 394 VAL 394 398 398 VAL VAL A . n 
A 1 395 LEU 395 399 399 LEU LEU A . n 
A 1 396 ASP 396 400 400 ASP ASP A . n 
A 1 397 GLU 397 401 401 GLU GLU A . n 
A 1 398 LYS 398 402 402 LYS LYS A . n 
A 1 399 VAL 399 403 403 VAL VAL A . n 
A 1 400 ALA 400 404 404 ALA ALA A . n 
A 1 401 ARG 401 405 405 ARG ARG A . n 
A 1 402 LEU 402 406 406 LEU LEU A . n 
A 1 403 HIS 403 407 407 HIS HIS A . n 
A 1 404 LEU 404 408 408 LEU LEU A . n 
A 1 405 GLY 405 409 409 GLY GLY A . n 
A 1 406 ARG 406 410 410 ARG ARG A . n 
A 1 407 ILE 407 411 411 ILE ILE A . n 
A 1 408 GLY 408 412 412 GLY GLY A . n 
A 1 409 ALA 409 413 413 ALA ALA A . n 
A 1 410 LYS 410 414 414 LYS LYS A . n 
A 1 411 LEU 411 415 415 LEU LEU A . n 
A 1 412 THR 412 416 416 THR THR A . n 
A 1 413 GLN 413 417 417 GLN GLN A . n 
A 1 414 LEU 414 418 418 LEU LEU A . n 
A 1 415 SER 415 419 419 SER SER A . n 
A 1 416 ASN 416 420 420 ASN ASN A . n 
A 1 417 GLU 417 421 421 GLU GLU A . n 
A 1 418 GLN 418 422 422 GLN GLN A . n 
A 1 419 ALA 419 423 423 ALA ALA A . n 
A 1 420 ASP 420 424 424 ASP ASP A . n 
A 1 421 TYR 421 425 425 TYR TYR A . n 
A 1 422 ILE 422 426 426 ILE ILE A . n 
A 1 423 GLY 423 427 427 GLY GLY A . n 
A 1 424 VAL 424 428 428 VAL VAL A . n 
A 1 425 ASP 425 429 429 ASP ASP A . n 
A 1 426 LYS 426 430 430 LYS LYS A . n 
A 1 427 ASN 427 431 431 ASN ASN A . n 
A 1 428 GLY 428 432 432 GLY GLY A . n 
A 1 429 PRO 429 433 433 PRO PRO A . n 
A 1 430 TYR 430 434 434 TYR TYR A . n 
A 1 431 LYS 431 435 435 LYS LYS A . n 
A 1 432 PRO 432 436 436 PRO PRO A . n 
A 1 433 ASP 433 437 437 ASP ASP A . n 
A 1 434 HIS 434 438 438 HIS HIS A . n 
A 1 435 TYR 435 439 439 TYR TYR A . n 
A 1 436 ARG 436 440 440 ARG ARG A . n 
A 1 437 TYR 437 441 441 TYR TYR A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NAD 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NAD 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 SO4 1   501 1   SO4 SO4 A . 
C 3 NAD 1   502 501 NAD NAD A . 
D 4 HOH 1   601 155 HOH HOH A . 
D 4 HOH 2   602 95  HOH HOH A . 
D 4 HOH 3   603 118 HOH HOH A . 
D 4 HOH 4   604 273 HOH HOH A . 
D 4 HOH 5   605 183 HOH HOH A . 
D 4 HOH 6   606 52  HOH HOH A . 
D 4 HOH 7   607 253 HOH HOH A . 
D 4 HOH 8   608 8   HOH HOH A . 
D 4 HOH 9   609 87  HOH HOH A . 
D 4 HOH 10  610 14  HOH HOH A . 
D 4 HOH 11  611 144 HOH HOH A . 
D 4 HOH 12  612 163 HOH HOH A . 
D 4 HOH 13  613 265 HOH HOH A . 
D 4 HOH 14  614 221 HOH HOH A . 
D 4 HOH 15  615 62  HOH HOH A . 
D 4 HOH 16  616 38  HOH HOH A . 
D 4 HOH 17  617 268 HOH HOH A . 
D 4 HOH 18  618 129 HOH HOH A . 
D 4 HOH 19  619 47  HOH HOH A . 
D 4 HOH 20  620 48  HOH HOH A . 
D 4 HOH 21  621 224 HOH HOH A . 
D 4 HOH 22  622 5   HOH HOH A . 
D 4 HOH 23  623 146 HOH HOH A . 
D 4 HOH 24  624 103 HOH HOH A . 
D 4 HOH 25  625 194 HOH HOH A . 
D 4 HOH 26  626 173 HOH HOH A . 
D 4 HOH 27  627 30  HOH HOH A . 
D 4 HOH 28  628 7   HOH HOH A . 
D 4 HOH 29  629 63  HOH HOH A . 
D 4 HOH 30  630 24  HOH HOH A . 
D 4 HOH 31  631 185 HOH HOH A . 
D 4 HOH 32  632 127 HOH HOH A . 
D 4 HOH 33  633 208 HOH HOH A . 
D 4 HOH 34  634 55  HOH HOH A . 
D 4 HOH 35  635 212 HOH HOH A . 
D 4 HOH 36  636 39  HOH HOH A . 
D 4 HOH 37  637 85  HOH HOH A . 
D 4 HOH 38  638 203 HOH HOH A . 
D 4 HOH 39  639 86  HOH HOH A . 
D 4 HOH 40  640 71  HOH HOH A . 
D 4 HOH 41  641 97  HOH HOH A . 
D 4 HOH 42  642 178 HOH HOH A . 
D 4 HOH 43  643 89  HOH HOH A . 
D 4 HOH 44  644 158 HOH HOH A . 
D 4 HOH 45  645 162 HOH HOH A . 
D 4 HOH 46  646 198 HOH HOH A . 
D 4 HOH 47  647 44  HOH HOH A . 
D 4 HOH 48  648 115 HOH HOH A . 
D 4 HOH 49  649 3   HOH HOH A . 
D 4 HOH 50  650 168 HOH HOH A . 
D 4 HOH 51  651 77  HOH HOH A . 
D 4 HOH 52  652 290 HOH HOH A . 
D 4 HOH 53  653 81  HOH HOH A . 
D 4 HOH 54  654 92  HOH HOH A . 
D 4 HOH 55  655 159 HOH HOH A . 
D 4 HOH 56  656 136 HOH HOH A . 
D 4 HOH 57  657 35  HOH HOH A . 
D 4 HOH 58  658 137 HOH HOH A . 
D 4 HOH 59  659 20  HOH HOH A . 
D 4 HOH 60  660 271 HOH HOH A . 
D 4 HOH 61  661 31  HOH HOH A . 
D 4 HOH 62  662 164 HOH HOH A . 
D 4 HOH 63  663 73  HOH HOH A . 
D 4 HOH 64  664 36  HOH HOH A . 
D 4 HOH 65  665 189 HOH HOH A . 
D 4 HOH 66  666 88  HOH HOH A . 
D 4 HOH 67  667 69  HOH HOH A . 
D 4 HOH 68  668 29  HOH HOH A . 
D 4 HOH 69  669 133 HOH HOH A . 
D 4 HOH 70  670 138 HOH HOH A . 
D 4 HOH 71  671 193 HOH HOH A . 
D 4 HOH 72  672 235 HOH HOH A . 
D 4 HOH 73  673 41  HOH HOH A . 
D 4 HOH 74  674 79  HOH HOH A . 
D 4 HOH 75  675 262 HOH HOH A . 
D 4 HOH 76  676 10  HOH HOH A . 
D 4 HOH 77  677 206 HOH HOH A . 
D 4 HOH 78  678 26  HOH HOH A . 
D 4 HOH 79  679 219 HOH HOH A . 
D 4 HOH 80  680 17  HOH HOH A . 
D 4 HOH 81  681 143 HOH HOH A . 
D 4 HOH 82  682 68  HOH HOH A . 
D 4 HOH 83  683 120 HOH HOH A . 
D 4 HOH 84  684 96  HOH HOH A . 
D 4 HOH 85  685 60  HOH HOH A . 
D 4 HOH 86  686 282 HOH HOH A . 
D 4 HOH 87  687 274 HOH HOH A . 
D 4 HOH 88  688 13  HOH HOH A . 
D 4 HOH 89  689 131 HOH HOH A . 
D 4 HOH 90  690 82  HOH HOH A . 
D 4 HOH 91  691 91  HOH HOH A . 
D 4 HOH 92  692 2   HOH HOH A . 
D 4 HOH 93  693 56  HOH HOH A . 
D 4 HOH 94  694 102 HOH HOH A . 
D 4 HOH 95  695 16  HOH HOH A . 
D 4 HOH 96  696 128 HOH HOH A . 
D 4 HOH 97  697 180 HOH HOH A . 
D 4 HOH 98  698 37  HOH HOH A . 
D 4 HOH 99  699 117 HOH HOH A . 
D 4 HOH 100 700 11  HOH HOH A . 
D 4 HOH 101 701 42  HOH HOH A . 
D 4 HOH 102 702 50  HOH HOH A . 
D 4 HOH 103 703 114 HOH HOH A . 
D 4 HOH 104 704 267 HOH HOH A . 
D 4 HOH 105 705 191 HOH HOH A . 
D 4 HOH 106 706 124 HOH HOH A . 
D 4 HOH 107 707 28  HOH HOH A . 
D 4 HOH 108 708 112 HOH HOH A . 
D 4 HOH 109 709 257 HOH HOH A . 
D 4 HOH 110 710 15  HOH HOH A . 
D 4 HOH 111 711 151 HOH HOH A . 
D 4 HOH 112 712 58  HOH HOH A . 
D 4 HOH 113 713 99  HOH HOH A . 
D 4 HOH 114 714 61  HOH HOH A . 
D 4 HOH 115 715 23  HOH HOH A . 
D 4 HOH 116 716 70  HOH HOH A . 
D 4 HOH 117 717 1   HOH HOH A . 
D 4 HOH 118 718 161 HOH HOH A . 
D 4 HOH 119 719 25  HOH HOH A . 
D 4 HOH 120 720 4   HOH HOH A . 
D 4 HOH 121 721 19  HOH HOH A . 
D 4 HOH 122 722 76  HOH HOH A . 
D 4 HOH 123 723 286 HOH HOH A . 
D 4 HOH 124 724 100 HOH HOH A . 
D 4 HOH 125 725 192 HOH HOH A . 
D 4 HOH 126 726 182 HOH HOH A . 
D 4 HOH 127 727 27  HOH HOH A . 
D 4 HOH 128 728 134 HOH HOH A . 
D 4 HOH 129 729 174 HOH HOH A . 
D 4 HOH 130 730 45  HOH HOH A . 
D 4 HOH 131 731 93  HOH HOH A . 
D 4 HOH 132 732 201 HOH HOH A . 
D 4 HOH 133 733 6   HOH HOH A . 
D 4 HOH 134 734 90  HOH HOH A . 
D 4 HOH 135 735 276 HOH HOH A . 
D 4 HOH 136 736 78  HOH HOH A . 
D 4 HOH 137 737 75  HOH HOH A . 
D 4 HOH 138 738 59  HOH HOH A . 
D 4 HOH 139 739 104 HOH HOH A . 
D 4 HOH 140 740 51  HOH HOH A . 
D 4 HOH 141 741 106 HOH HOH A . 
D 4 HOH 142 742 18  HOH HOH A . 
D 4 HOH 143 743 101 HOH HOH A . 
D 4 HOH 144 744 231 HOH HOH A . 
D 4 HOH 145 745 12  HOH HOH A . 
D 4 HOH 146 746 214 HOH HOH A . 
D 4 HOH 147 747 150 HOH HOH A . 
D 4 HOH 148 748 107 HOH HOH A . 
D 4 HOH 149 749 145 HOH HOH A . 
D 4 HOH 150 750 54  HOH HOH A . 
D 4 HOH 151 751 66  HOH HOH A . 
D 4 HOH 152 752 175 HOH HOH A . 
D 4 HOH 153 753 266 HOH HOH A . 
D 4 HOH 154 754 94  HOH HOH A . 
D 4 HOH 155 755 154 HOH HOH A . 
D 4 HOH 156 756 67  HOH HOH A . 
D 4 HOH 157 757 270 HOH HOH A . 
D 4 HOH 158 758 65  HOH HOH A . 
D 4 HOH 159 759 255 HOH HOH A . 
D 4 HOH 160 760 43  HOH HOH A . 
D 4 HOH 161 761 121 HOH HOH A . 
D 4 HOH 162 762 244 HOH HOH A . 
D 4 HOH 163 763 166 HOH HOH A . 
D 4 HOH 164 764 109 HOH HOH A . 
D 4 HOH 165 765 200 HOH HOH A . 
D 4 HOH 166 766 84  HOH HOH A . 
D 4 HOH 167 767 153 HOH HOH A . 
D 4 HOH 168 768 32  HOH HOH A . 
D 4 HOH 169 769 142 HOH HOH A . 
D 4 HOH 170 770 187 HOH HOH A . 
D 4 HOH 171 771 21  HOH HOH A . 
D 4 HOH 172 772 254 HOH HOH A . 
D 4 HOH 173 773 249 HOH HOH A . 
D 4 HOH 174 774 119 HOH HOH A . 
D 4 HOH 175 775 289 HOH HOH A . 
D 4 HOH 176 776 22  HOH HOH A . 
D 4 HOH 177 777 123 HOH HOH A . 
D 4 HOH 178 778 197 HOH HOH A . 
D 4 HOH 179 779 217 HOH HOH A . 
D 4 HOH 180 780 57  HOH HOH A . 
D 4 HOH 181 781 111 HOH HOH A . 
D 4 HOH 182 782 156 HOH HOH A . 
D 4 HOH 183 783 288 HOH HOH A . 
D 4 HOH 184 784 226 HOH HOH A . 
D 4 HOH 185 785 246 HOH HOH A . 
D 4 HOH 186 786 116 HOH HOH A . 
D 4 HOH 187 787 245 HOH HOH A . 
D 4 HOH 188 788 148 HOH HOH A . 
D 4 HOH 189 789 210 HOH HOH A . 
D 4 HOH 190 790 157 HOH HOH A . 
D 4 HOH 191 791 33  HOH HOH A . 
D 4 HOH 192 792 80  HOH HOH A . 
D 4 HOH 193 793 213 HOH HOH A . 
D 4 HOH 194 794 195 HOH HOH A . 
D 4 HOH 195 795 135 HOH HOH A . 
D 4 HOH 196 796 9   HOH HOH A . 
D 4 HOH 197 797 74  HOH HOH A . 
D 4 HOH 198 798 122 HOH HOH A . 
D 4 HOH 199 799 98  HOH HOH A . 
D 4 HOH 200 800 272 HOH HOH A . 
D 4 HOH 201 801 227 HOH HOH A . 
D 4 HOH 202 802 238 HOH HOH A . 
D 4 HOH 203 803 40  HOH HOH A . 
D 4 HOH 204 804 240 HOH HOH A . 
D 4 HOH 205 805 220 HOH HOH A . 
D 4 HOH 206 806 132 HOH HOH A . 
D 4 HOH 207 807 171 HOH HOH A . 
D 4 HOH 208 808 179 HOH HOH A . 
D 4 HOH 209 809 230 HOH HOH A . 
D 4 HOH 210 810 113 HOH HOH A . 
D 4 HOH 211 811 209 HOH HOH A . 
D 4 HOH 212 812 205 HOH HOH A . 
D 4 HOH 213 813 34  HOH HOH A . 
D 4 HOH 214 814 285 HOH HOH A . 
D 4 HOH 215 815 207 HOH HOH A . 
D 4 HOH 216 816 250 HOH HOH A . 
D 4 HOH 217 817 167 HOH HOH A . 
D 4 HOH 218 818 53  HOH HOH A . 
D 4 HOH 219 819 125 HOH HOH A . 
D 4 HOH 220 820 211 HOH HOH A . 
D 4 HOH 221 821 234 HOH HOH A . 
D 4 HOH 222 822 236 HOH HOH A . 
D 4 HOH 223 823 184 HOH HOH A . 
D 4 HOH 224 824 186 HOH HOH A . 
D 4 HOH 225 825 281 HOH HOH A . 
D 4 HOH 226 826 241 HOH HOH A . 
D 4 HOH 227 827 223 HOH HOH A . 
D 4 HOH 228 828 108 HOH HOH A . 
D 4 HOH 229 829 64  HOH HOH A . 
D 4 HOH 230 830 247 HOH HOH A . 
D 4 HOH 231 831 141 HOH HOH A . 
D 4 HOH 232 832 260 HOH HOH A . 
D 4 HOH 233 833 83  HOH HOH A . 
D 4 HOH 234 834 160 HOH HOH A . 
D 4 HOH 235 835 181 HOH HOH A . 
D 4 HOH 236 836 105 HOH HOH A . 
D 4 HOH 237 837 72  HOH HOH A . 
D 4 HOH 238 838 190 HOH HOH A . 
D 4 HOH 239 839 275 HOH HOH A . 
D 4 HOH 240 840 277 HOH HOH A . 
D 4 HOH 241 841 165 HOH HOH A . 
D 4 HOH 242 842 218 HOH HOH A . 
D 4 HOH 243 843 216 HOH HOH A . 
D 4 HOH 244 844 222 HOH HOH A . 
D 4 HOH 245 845 261 HOH HOH A . 
D 4 HOH 246 846 110 HOH HOH A . 
D 4 HOH 247 847 152 HOH HOH A . 
D 4 HOH 248 848 228 HOH HOH A . 
D 4 HOH 249 849 251 HOH HOH A . 
D 4 HOH 250 850 172 HOH HOH A . 
D 4 HOH 251 851 176 HOH HOH A . 
D 4 HOH 252 852 252 HOH HOH A . 
D 4 HOH 253 853 46  HOH HOH A . 
D 4 HOH 254 854 283 HOH HOH A . 
D 4 HOH 255 855 242 HOH HOH A . 
D 4 HOH 256 856 278 HOH HOH A . 
D 4 HOH 257 857 126 HOH HOH A . 
D 4 HOH 258 858 280 HOH HOH A . 
D 4 HOH 259 859 188 HOH HOH A . 
D 4 HOH 260 860 243 HOH HOH A . 
D 4 HOH 261 861 269 HOH HOH A . 
D 4 HOH 262 862 232 HOH HOH A . 
D 4 HOH 263 863 170 HOH HOH A . 
D 4 HOH 264 864 199 HOH HOH A . 
D 4 HOH 265 865 284 HOH HOH A . 
D 4 HOH 266 866 256 HOH HOH A . 
D 4 HOH 267 867 204 HOH HOH A . 
D 4 HOH 268 868 279 HOH HOH A . 
D 4 HOH 269 869 225 HOH HOH A . 
D 4 HOH 270 870 140 HOH HOH A . 
D 4 HOH 271 871 263 HOH HOH A . 
D 4 HOH 272 872 202 HOH HOH A . 
D 4 HOH 273 873 259 HOH HOH A . 
D 4 HOH 274 874 239 HOH HOH A . 
D 4 HOH 275 875 258 HOH HOH A . 
D 4 HOH 276 876 149 HOH HOH A . 
D 4 HOH 277 877 215 HOH HOH A . 
D 4 HOH 278 878 287 HOH HOH A . 
D 4 HOH 279 879 229 HOH HOH A . 
D 4 HOH 280 880 49  HOH HOH A . 
D 4 HOH 281 881 237 HOH HOH A . 
D 4 HOH 282 882 248 HOH HOH A . 
D 4 HOH 283 883 264 HOH HOH A . 
D 4 HOH 284 884 139 HOH HOH A . 
D 4 HOH 285 885 169 HOH HOH A . 
D 4 HOH 286 886 233 HOH HOH A . 
D 4 HOH 287 887 177 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-3000    ? ? ? 7.21  1 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.13  2 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.27  3 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? HKL-3000    ? ? ? 7.21  4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? 2.7.0 5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8WWG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     130.467 
_cell.length_a_esd                 ? 
_cell.length_b                     130.467 
_cell.length_b_esd                 ? 
_cell.length_c                     115.523 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8WWG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                180 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 62 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8WWG 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.01 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          59.20 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;2.0 M Ammonium sulfate
0.1 M Bis-Tris pH 5.5
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    Si111 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97923 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97923 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          38.70 
_reflns.entry_id                                       8WWG 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.921 
_reflns.d_resolution_low                               42.805 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     1710554 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.45 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                38.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          56.33 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.981 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.921 
_reflns_shell.d_res_low                                     1.99 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             44433 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.802 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.005 
_refine.aniso_B[1][2]                            -0.003 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            -0.005 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            0.017 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               40.573 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.945 
_refine.correlation_coeff_Fo_to_Fc_free          0.951 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8WWG 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.921 
_refine.ls_d_res_low                             42.705 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     44469 
_refine.ls_number_reflns_R_free                  2193 
_refine.ls_number_reflns_R_work                  42276 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.595 
_refine.ls_percent_reflns_R_free                 4.932 
_refine.ls_R_factor_all                          0.210 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2204 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2095 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.149 
_refine.pdbx_overall_ESU_R_Free                  0.127 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.921 
_refine_hist.d_res_low                        42.705 
_refine_hist.number_atoms_solvent             287 
_refine_hist.number_atoms_total               3642 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3306 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         49 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  0.012  3421 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.016  3252 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.404  1.652  4650 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.684  1.580  7481 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.517  5.000  426  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 4.377  5.000  17   ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.270  5.000  1    ? r_dihedral_angle_other_2_deg   ? ? 
'X-RAY DIFFRACTION' ? 16.789 10.000 582  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 17.789 10.000 150  ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.067  0.200  531  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.004  0.020  4011 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.003  0.020  752  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.212  0.200  700  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.210  0.200  3078 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.180  0.200  1709 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.079  0.200  1793 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.176  0.200  258  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.015  0.200  1    ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.149  0.200  21   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.207  0.200  239  ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.210  0.200  54   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 3.797  4.239  1707 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.795  4.239  1707 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.414  7.579  2132 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.414  7.578  2133 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 4.782  4.557  1714 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 4.780  4.556  1715 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 6.510  8.210  2518 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 6.508  8.209  2519 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 7.387  43.589 3988 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 7.387  43.584 3989 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.921 1.971  3240 . 151 2995 97.0988  . 0.279 . . 0.278 . . . . . 0.229 . 20 . 0.940 0.939 0.287 
'X-RAY DIFFRACTION' 1.971 2.025  3148 . 164 2984 100.0000 . 0.258 . . 0.256 . . . . . 0.211 . 20 . 0.951 0.944 0.292 
'X-RAY DIFFRACTION' 2.025 2.083  3067 . 146 2921 100.0000 . 0.248 . . 0.247 . . . . . 0.204 . 20 . 0.957 0.957 0.265 
'X-RAY DIFFRACTION' 2.083 2.147  2992 . 145 2846 99.9666  . 0.227 . . 0.224 . . . . . 0.187 . 20 . 0.966 0.953 0.275 
'X-RAY DIFFRACTION' 2.147 2.218  2896 . 141 2755 100.0000 . 0.211 . . 0.210 . . . . . 0.177 . 20 . 0.971 0.964 0.233 
'X-RAY DIFFRACTION' 2.218 2.295  2818 . 149 2669 100.0000 . 0.212 . . 0.211 . . . . . 0.180 . 20 . 0.971 0.966 0.241 
'X-RAY DIFFRACTION' 2.295 2.381  2714 . 127 2587 100.0000 . 0.203 . . 0.203 . . . . . 0.175 . 20 . 0.974 0.967 0.222 
'X-RAY DIFFRACTION' 2.381 2.478  2604 . 122 2482 100.0000 . 0.198 . . 0.196 . . . . . 0.176 . 20 . 0.976 0.965 0.250 
'X-RAY DIFFRACTION' 2.478 2.588  2524 . 121 2403 100.0000 . 0.206 . . 0.202 . . . . . 0.180 . 20 . 0.975 0.947 0.290 
'X-RAY DIFFRACTION' 2.588 2.714  2416 . 126 2290 100.0000 . 0.205 . . 0.203 . . . . . 0.186 . 20 . 0.973 0.967 0.228 
'X-RAY DIFFRACTION' 2.714 2.860  2303 . 126 2177 100.0000 . 0.206 . . 0.204 . . . . . 0.190 . 20 . 0.973 0.962 0.244 
'X-RAY DIFFRACTION' 2.860 3.033  2182 . 101 2081 100.0000 . 0.201 . . 0.200 . . . . . 0.189 . 20 . 0.974 0.971 0.219 
'X-RAY DIFFRACTION' 3.033 3.241  2056 . 90  1965 99.9514  . 0.213 . . 0.212 . . . . . 0.206 . 20 . 0.971 0.965 0.218 
'X-RAY DIFFRACTION' 3.241 3.499  1930 . 96  1834 100.0000 . 0.201 . . 0.200 . . . . . 0.199 . 20 . 0.973 0.970 0.224 
'X-RAY DIFFRACTION' 3.499 3.831  1783 . 88  1695 100.0000 . 0.180 . . 0.181 . . . . . 0.183 . 20 . 0.978 0.982 0.163 
'X-RAY DIFFRACTION' 3.831 4.278  1634 . 80  1554 100.0000 . 0.165 . . 0.164 . . . . . 0.176 . 20 . 0.982 0.978 0.186 
'X-RAY DIFFRACTION' 4.278 4.932  1448 . 90  1358 100.0000 . 0.186 . . 0.187 . . . . . 0.203 . 20 . 0.972 0.984 0.158 
'X-RAY DIFFRACTION' 4.932 6.020  1256 . 51  1202 99.7611  . 0.251 . . 0.253 . . . . . 0.273 . 20 . 0.951 0.969 0.211 
'X-RAY DIFFRACTION' 6.020 8.431  1002 . 53  942  99.3014  . 0.263 . . 0.264 . . . . . 0.277 . 20 . 0.952 0.957 0.253 
'X-RAY DIFFRACTION' 8.431 42.705 629  . 26  536  89.3482  . 0.265 . . 0.262 . . . . . 0.281 . 20 . 0.952 0.949 0.329 
# 
_struct.entry_id                     8WWG 
_struct.title                        
'The crystal structure of Legionella pneumophila adenosylhomocysteinase Lpg2021 complex with NAD' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8WWG 
_struct_keywords.text            'Legionella pneumophila, SAH hydrolase, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A2S6F4T2_LEGPN 
_struct_ref.pdbx_db_accession          A0A2S6F4T2 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;QDYKVAEISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVALGAEVRWSSCNIFST
QDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQVVHQKHPKLLTAIKGVSEETTTGVAR
LYEMAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCAQALRGQGATVLVAE
IDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQSLKQYQWENIKPQV
DHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLDEKVARLHLGRIGAK
LTQLSNEQADYIGVDKNGPYKPDHYRY
;
_struct_ref.pdbx_align_begin           15 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8WWG 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 11 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 437 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A2S6F4T2 
_struct_ref_seq.db_align_beg                  15 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  441 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       15 
_struct_ref_seq.pdbx_auth_seq_align_end       441 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8WWG MET A 1  ? UNP A0A2S6F4T2 ? ? 'initiating methionine' 5  1  
1 8WWG GLY A 2  ? UNP A0A2S6F4T2 ? ? 'expression tag'        6  2  
1 8WWG HIS A 3  ? UNP A0A2S6F4T2 ? ? 'expression tag'        7  3  
1 8WWG HIS A 4  ? UNP A0A2S6F4T2 ? ? 'expression tag'        8  4  
1 8WWG HIS A 5  ? UNP A0A2S6F4T2 ? ? 'expression tag'        9  5  
1 8WWG HIS A 6  ? UNP A0A2S6F4T2 ? ? 'expression tag'        10 6  
1 8WWG HIS A 7  ? UNP A0A2S6F4T2 ? ? 'expression tag'        11 7  
1 8WWG HIS A 8  ? UNP A0A2S6F4T2 ? ? 'expression tag'        12 8  
1 8WWG HIS A 9  ? UNP A0A2S6F4T2 ? ? 'expression tag'        13 9  
1 8WWG HIS A 10 ? UNP A0A2S6F4T2 ? ? 'expression tag'        14 10 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 9470  ? 
1 MORE         -91   ? 
1 'SSA (A^2)'  30230 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000  
0.0000000000 0.0000000000    0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 4_545 -x,-y-1,z -1.0000000000 0.0000000000 0.0000000000 65.2335000000 0.0000000000 -1.0000000000 
0.0000000000 -112.9877363555 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 17  ? SER A 19  ? GLU A 21  SER A 23  5 ? 3  
HELX_P HELX_P2  AA2 LEU A 20  ? THR A 33  ? LEU A 24  THR A 37  1 ? 14 
HELX_P HELX_P3  AA3 MET A 35  ? SER A 46  ? MET A 39  SER A 50  1 ? 12 
HELX_P HELX_P4  AA4 THR A 63  ? LEU A 76  ? THR A 67  LEU A 80  1 ? 14 
HELX_P HELX_P5  AA5 GLN A 91  ? LYS A 101 ? GLN A 95  LYS A 105 1 ? 11 
HELX_P HELX_P6  AA6 THR A 112 ? THR A 123 ? THR A 116 THR A 127 1 ? 12 
HELX_P HELX_P7  AA7 LEU A 124 ? SER A 125 ? LEU A 128 SER A 129 5 ? 2  
HELX_P HELX_P8  AA8 GLY A 126 ? TRP A 130 ? GLY A 130 TRP A 134 5 ? 5  
HELX_P HELX_P9  AA9 GLY A 140 ? HIS A 150 ? GLY A 144 HIS A 154 1 ? 11 
HELX_P HELX_P10 AB1 HIS A 150 ? THR A 155 ? HIS A 154 THR A 159 1 ? 6  
HELX_P HELX_P11 AB2 THR A 164 ? HIS A 177 ? THR A 168 HIS A 181 1 ? 14 
HELX_P HELX_P12 AB3 ALA A 190 ? LYS A 195 ? ALA A 194 LYS A 199 1 ? 6  
HELX_P HELX_P13 AB4 PHE A 196 ? THR A 214 ? PHE A 200 THR A 218 1 ? 19 
HELX_P HELX_P14 AB5 GLY A 229 ? GLN A 242 ? GLY A 233 GLN A 246 1 ? 14 
HELX_P HELX_P15 AB6 ASP A 252 ? GLU A 262 ? ASP A 256 GLU A 266 1 ? 11 
HELX_P HELX_P16 AB7 THR A 268 ? ALA A 273 ? THR A 272 ALA A 277 1 ? 6  
HELX_P HELX_P17 AB8 GLU A 274 ? VAL A 276 ? GLU A 278 VAL A 280 5 ? 3  
HELX_P HELX_P18 AB9 THR A 290 ? MET A 297 ? THR A 294 MET A 301 1 ? 8  
HELX_P HELX_P19 AC1 PHE A 309 ? ILE A 313 ? PHE A 313 ILE A 317 5 ? 5  
HELX_P HELX_P20 AC2 ASP A 314 ? LYS A 319 ? ASP A 318 LYS A 323 5 ? 6  
HELX_P HELX_P21 AC3 GLU A 346 ? ARG A 348 ? GLU A 350 ARG A 352 5 ? 3  
HELX_P HELX_P22 AC4 LEU A 349 ? CYS A 354 ? LEU A 353 CYS A 358 1 ? 6  
HELX_P HELX_P23 AC5 PRO A 359 ? SER A 381 ? PRO A 363 SER A 385 1 ? 23 
HELX_P HELX_P24 AC6 SER A 382 ? TYR A 384 ? SER A 386 TYR A 388 5 ? 3  
HELX_P HELX_P25 AC7 PRO A 392 ? GLY A 405 ? PRO A 396 GLY A 409 1 ? 14 
HELX_P HELX_P26 AC8 SER A 415 ? GLY A 423 ? SER A 419 GLY A 427 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           428 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            432 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    429 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     433 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.15 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA2 6 7 ? anti-parallel 
AA2 7 8 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 105 ? PHE A 106 ? VAL A 109 PHE A 110 
AA1 2 GLU A 79  ? SER A 83  ? GLU A 83  SER A 87  
AA1 3 ARG A 55  ? CYS A 59  ? ARG A 59  CYS A 63  
AA1 4 LEU A 134 ? ASP A 137 ? LEU A 138 ASP A 141 
AA1 5 VAL A 160 ? GLU A 162 ? VAL A 164 GLU A 166 
AA1 6 ALA A 184 ? ASN A 186 ? ALA A 188 ASN A 190 
AA1 7 VAL A 388 ? TYR A 389 ? VAL A 392 TYR A 393 
AA2 1 ARG A 265 ? VAL A 266 ? ARG A 269 VAL A 270 
AA2 2 THR A 245 ? ALA A 249 ? THR A 249 ALA A 253 
AA2 3 VAL A 222 ? LEU A 226 ? VAL A 226 LEU A 230 
AA2 4 ILE A 278 ? THR A 281 ? ILE A 282 THR A 285 
AA2 5 ALA A 301 ? ASN A 305 ? ALA A 305 ASN A 309 
AA2 6 ARG A 340 ? LEU A 344 ? ARG A 344 LEU A 348 
AA2 7 VAL A 330 ? ILE A 334 ? VAL A 334 ILE A 338 
AA2 8 GLN A 322 ? LYS A 327 ? GLN A 326 LYS A 331 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O PHE A 106 ? O PHE A 110 N TRP A 82  ? N TRP A 86  
AA1 2 3 O GLU A 79  ? O GLU A 83  N ILE A 56  ? N ILE A 60  
AA1 3 4 N CYS A 59  ? N CYS A 63  O LEU A 136 ? O LEU A 140 
AA1 4 5 N ASP A 137 ? N ASP A 141 O SER A 161 ? O SER A 165 
AA1 5 6 N VAL A 160 ? N VAL A 164 O ILE A 185 ? O ILE A 189 
AA1 6 7 N ASN A 186 ? N ASN A 190 O TYR A 389 ? O TYR A 393 
AA2 1 2 O ARG A 265 ? O ARG A 269 N VAL A 248 ? N VAL A 252 
AA2 2 3 O LEU A 247 ? O LEU A 251 N ALA A 223 ? N ALA A 227 
AA2 3 4 N LEU A 224 ? N LEU A 228 O ILE A 278 ? O ILE A 282 
AA2 4 5 N VAL A 279 ? N VAL A 283 O ILE A 302 ? O ILE A 306 
AA2 5 6 N LEU A 303 ? N LEU A 307 O ILE A 342 ? O ILE A 346 
AA2 6 7 O ILE A 343 ? O ILE A 347 N ASP A 331 ? N ASP A 335 
AA2 7 8 O HIS A 332 ? O HIS A 336 N GLU A 324 ? N GLU A 328 
# 
_pdbx_entry_details.entry_id                   8WWG 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 HIS A 65  ? ? -28.80  117.00  
2 1 ASN A 132 ? ? 70.93   31.30   
3 1 LYS A 197 ? ? -108.00 -72.02  
4 1 PHE A 200 ? ? -128.52 -70.83  
5 1 LEU A 203 ? ? -88.80  -71.06  
6 1 ASP A 219 ? ? -91.04  33.37   
7 1 ALA A 286 ? ? -140.00 37.35   
8 1 LEU A 353 ? ? -34.91  111.69  
9 1 ALA A 359 ? ? -142.37 -150.69 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     779 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   D 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z          
2  x-y,x,z+1/3    
3  y,-x+y,z+2/3   
4  -y,x-y,z+2/3   
5  -x+y,-x,z+1/3  
6  x-y,-y,-z      
7  -x,-x+y,-z+1/3 
8  -x,-y,z        
9  y,x,-z+2/3     
10 -y,-x,-z+2/3   
11 -x+y,y,-z      
12 x,x-y,-z+1/3   
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       887 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.86 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 5  ? A MET 1  
2  1 Y 1 A GLY 6  ? A GLY 2  
3  1 Y 1 A HIS 7  ? A HIS 3  
4  1 Y 1 A HIS 8  ? A HIS 4  
5  1 Y 1 A HIS 9  ? A HIS 5  
6  1 Y 1 A HIS 10 ? A HIS 6  
7  1 Y 1 A HIS 11 ? A HIS 7  
8  1 Y 1 A HIS 12 ? A HIS 8  
9  1 Y 1 A HIS 13 ? A HIS 9  
10 1 Y 1 A HIS 14 ? A HIS 10 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
NAD PA   P N S 250 
NAD O1A  O N N 251 
NAD O2A  O N N 252 
NAD O5B  O N N 253 
NAD C5B  C N N 254 
NAD C4B  C N R 255 
NAD O4B  O N N 256 
NAD C3B  C N S 257 
NAD O3B  O N N 258 
NAD C2B  C N R 259 
NAD O2B  O N N 260 
NAD C1B  C N R 261 
NAD N9A  N Y N 262 
NAD C8A  C Y N 263 
NAD N7A  N Y N 264 
NAD C5A  C Y N 265 
NAD C6A  C Y N 266 
NAD N6A  N N N 267 
NAD N1A  N Y N 268 
NAD C2A  C Y N 269 
NAD N3A  N Y N 270 
NAD C4A  C Y N 271 
NAD O3   O N N 272 
NAD PN   P N N 273 
NAD O1N  O N N 274 
NAD O2N  O N N 275 
NAD O5D  O N N 276 
NAD C5D  C N N 277 
NAD C4D  C N R 278 
NAD O4D  O N N 279 
NAD C3D  C N S 280 
NAD O3D  O N N 281 
NAD C2D  C N R 282 
NAD O2D  O N N 283 
NAD C1D  C N R 284 
NAD N1N  N Y N 285 
NAD C2N  C Y N 286 
NAD C3N  C Y N 287 
NAD C7N  C N N 288 
NAD O7N  O N N 289 
NAD N7N  N N N 290 
NAD C4N  C Y N 291 
NAD C5N  C Y N 292 
NAD C6N  C Y N 293 
NAD HOA2 H N N 294 
NAD H51A H N N 295 
NAD H52A H N N 296 
NAD H4B  H N N 297 
NAD H3B  H N N 298 
NAD HO3A H N N 299 
NAD H2B  H N N 300 
NAD HO2A H N N 301 
NAD H1B  H N N 302 
NAD H8A  H N N 303 
NAD H61A H N N 304 
NAD H62A H N N 305 
NAD H2A  H N N 306 
NAD H51N H N N 307 
NAD H52N H N N 308 
NAD H4D  H N N 309 
NAD H3D  H N N 310 
NAD HO3N H N N 311 
NAD H2D  H N N 312 
NAD HO2N H N N 313 
NAD H1D  H N N 314 
NAD H2N  H N N 315 
NAD H71N H N N 316 
NAD H72N H N N 317 
NAD H4N  H N N 318 
NAD H5N  H N N 319 
NAD H6N  H N N 320 
PHE N    N N N 321 
PHE CA   C N S 322 
PHE C    C N N 323 
PHE O    O N N 324 
PHE CB   C N N 325 
PHE CG   C Y N 326 
PHE CD1  C Y N 327 
PHE CD2  C Y N 328 
PHE CE1  C Y N 329 
PHE CE2  C Y N 330 
PHE CZ   C Y N 331 
PHE OXT  O N N 332 
PHE H    H N N 333 
PHE H2   H N N 334 
PHE HA   H N N 335 
PHE HB2  H N N 336 
PHE HB3  H N N 337 
PHE HD1  H N N 338 
PHE HD2  H N N 339 
PHE HE1  H N N 340 
PHE HE2  H N N 341 
PHE HZ   H N N 342 
PHE HXT  H N N 343 
PRO N    N N N 344 
PRO CA   C N S 345 
PRO C    C N N 346 
PRO O    O N N 347 
PRO CB   C N N 348 
PRO CG   C N N 349 
PRO CD   C N N 350 
PRO OXT  O N N 351 
PRO H    H N N 352 
PRO HA   H N N 353 
PRO HB2  H N N 354 
PRO HB3  H N N 355 
PRO HG2  H N N 356 
PRO HG3  H N N 357 
PRO HD2  H N N 358 
PRO HD3  H N N 359 
PRO HXT  H N N 360 
SER N    N N N 361 
SER CA   C N S 362 
SER C    C N N 363 
SER O    O N N 364 
SER CB   C N N 365 
SER OG   O N N 366 
SER OXT  O N N 367 
SER H    H N N 368 
SER H2   H N N 369 
SER HA   H N N 370 
SER HB2  H N N 371 
SER HB3  H N N 372 
SER HG   H N N 373 
SER HXT  H N N 374 
SO4 S    S N N 375 
SO4 O1   O N N 376 
SO4 O2   O N N 377 
SO4 O3   O N N 378 
SO4 O4   O N N 379 
THR N    N N N 380 
THR CA   C N S 381 
THR C    C N N 382 
THR O    O N N 383 
THR CB   C N R 384 
THR OG1  O N N 385 
THR CG2  C N N 386 
THR OXT  O N N 387 
THR H    H N N 388 
THR H2   H N N 389 
THR HA   H N N 390 
THR HB   H N N 391 
THR HG1  H N N 392 
THR HG21 H N N 393 
THR HG22 H N N 394 
THR HG23 H N N 395 
THR HXT  H N N 396 
TRP N    N N N 397 
TRP CA   C N S 398 
TRP C    C N N 399 
TRP O    O N N 400 
TRP CB   C N N 401 
TRP CG   C Y N 402 
TRP CD1  C Y N 403 
TRP CD2  C Y N 404 
TRP NE1  N Y N 405 
TRP CE2  C Y N 406 
TRP CE3  C Y N 407 
TRP CZ2  C Y N 408 
TRP CZ3  C Y N 409 
TRP CH2  C Y N 410 
TRP OXT  O N N 411 
TRP H    H N N 412 
TRP H2   H N N 413 
TRP HA   H N N 414 
TRP HB2  H N N 415 
TRP HB3  H N N 416 
TRP HD1  H N N 417 
TRP HE1  H N N 418 
TRP HE3  H N N 419 
TRP HZ2  H N N 420 
TRP HZ3  H N N 421 
TRP HH2  H N N 422 
TRP HXT  H N N 423 
TYR N    N N N 424 
TYR CA   C N S 425 
TYR C    C N N 426 
TYR O    O N N 427 
TYR CB   C N N 428 
TYR CG   C Y N 429 
TYR CD1  C Y N 430 
TYR CD2  C Y N 431 
TYR CE1  C Y N 432 
TYR CE2  C Y N 433 
TYR CZ   C Y N 434 
TYR OH   O N N 435 
TYR OXT  O N N 436 
TYR H    H N N 437 
TYR H2   H N N 438 
TYR HA   H N N 439 
TYR HB2  H N N 440 
TYR HB3  H N N 441 
TYR HD1  H N N 442 
TYR HD2  H N N 443 
TYR HE1  H N N 444 
TYR HE2  H N N 445 
TYR HH   H N N 446 
TYR HXT  H N N 447 
VAL N    N N N 448 
VAL CA   C N S 449 
VAL C    C N N 450 
VAL O    O N N 451 
VAL CB   C N N 452 
VAL CG1  C N N 453 
VAL CG2  C N N 454 
VAL OXT  O N N 455 
VAL H    H N N 456 
VAL H2   H N N 457 
VAL HA   H N N 458 
VAL HB   H N N 459 
VAL HG11 H N N 460 
VAL HG12 H N N 461 
VAL HG13 H N N 462 
VAL HG21 H N N 463 
VAL HG22 H N N 464 
VAL HG23 H N N 465 
VAL HXT  H N N 466 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NAD PA  O1A  doub N N 237 
NAD PA  O2A  sing N N 238 
NAD PA  O5B  sing N N 239 
NAD PA  O3   sing N N 240 
NAD O2A HOA2 sing N N 241 
NAD O5B C5B  sing N N 242 
NAD C5B C4B  sing N N 243 
NAD C5B H51A sing N N 244 
NAD C5B H52A sing N N 245 
NAD C4B O4B  sing N N 246 
NAD C4B C3B  sing N N 247 
NAD C4B H4B  sing N N 248 
NAD O4B C1B  sing N N 249 
NAD C3B O3B  sing N N 250 
NAD C3B C2B  sing N N 251 
NAD C3B H3B  sing N N 252 
NAD O3B HO3A sing N N 253 
NAD C2B O2B  sing N N 254 
NAD C2B C1B  sing N N 255 
NAD C2B H2B  sing N N 256 
NAD O2B HO2A sing N N 257 
NAD C1B N9A  sing N N 258 
NAD C1B H1B  sing N N 259 
NAD N9A C8A  sing Y N 260 
NAD N9A C4A  sing Y N 261 
NAD C8A N7A  doub Y N 262 
NAD C8A H8A  sing N N 263 
NAD N7A C5A  sing Y N 264 
NAD C5A C6A  sing Y N 265 
NAD C5A C4A  doub Y N 266 
NAD C6A N6A  sing N N 267 
NAD C6A N1A  doub Y N 268 
NAD N6A H61A sing N N 269 
NAD N6A H62A sing N N 270 
NAD N1A C2A  sing Y N 271 
NAD C2A N3A  doub Y N 272 
NAD C2A H2A  sing N N 273 
NAD N3A C4A  sing Y N 274 
NAD O3  PN   sing N N 275 
NAD PN  O1N  doub N N 276 
NAD PN  O2N  sing N N 277 
NAD PN  O5D  sing N N 278 
NAD O5D C5D  sing N N 279 
NAD C5D C4D  sing N N 280 
NAD C5D H51N sing N N 281 
NAD C5D H52N sing N N 282 
NAD C4D O4D  sing N N 283 
NAD C4D C3D  sing N N 284 
NAD C4D H4D  sing N N 285 
NAD O4D C1D  sing N N 286 
NAD C3D O3D  sing N N 287 
NAD C3D C2D  sing N N 288 
NAD C3D H3D  sing N N 289 
NAD O3D HO3N sing N N 290 
NAD C2D O2D  sing N N 291 
NAD C2D C1D  sing N N 292 
NAD C2D H2D  sing N N 293 
NAD O2D HO2N sing N N 294 
NAD C1D N1N  sing N N 295 
NAD C1D H1D  sing N N 296 
NAD N1N C2N  sing Y N 297 
NAD N1N C6N  doub Y N 298 
NAD C2N C3N  doub Y N 299 
NAD C2N H2N  sing N N 300 
NAD C3N C7N  sing N N 301 
NAD C3N C4N  sing Y N 302 
NAD C7N O7N  doub N N 303 
NAD C7N N7N  sing N N 304 
NAD N7N H71N sing N N 305 
NAD N7N H72N sing N N 306 
NAD C4N C5N  doub Y N 307 
NAD C4N H4N  sing N N 308 
NAD C5N C6N  sing Y N 309 
NAD C5N H5N  sing N N 310 
NAD C6N H6N  sing N N 311 
PHE N   CA   sing N N 312 
PHE N   H    sing N N 313 
PHE N   H2   sing N N 314 
PHE CA  C    sing N N 315 
PHE CA  CB   sing N N 316 
PHE CA  HA   sing N N 317 
PHE C   O    doub N N 318 
PHE C   OXT  sing N N 319 
PHE CB  CG   sing N N 320 
PHE CB  HB2  sing N N 321 
PHE CB  HB3  sing N N 322 
PHE CG  CD1  doub Y N 323 
PHE CG  CD2  sing Y N 324 
PHE CD1 CE1  sing Y N 325 
PHE CD1 HD1  sing N N 326 
PHE CD2 CE2  doub Y N 327 
PHE CD2 HD2  sing N N 328 
PHE CE1 CZ   doub Y N 329 
PHE CE1 HE1  sing N N 330 
PHE CE2 CZ   sing Y N 331 
PHE CE2 HE2  sing N N 332 
PHE CZ  HZ   sing N N 333 
PHE OXT HXT  sing N N 334 
PRO N   CA   sing N N 335 
PRO N   CD   sing N N 336 
PRO N   H    sing N N 337 
PRO CA  C    sing N N 338 
PRO CA  CB   sing N N 339 
PRO CA  HA   sing N N 340 
PRO C   O    doub N N 341 
PRO C   OXT  sing N N 342 
PRO CB  CG   sing N N 343 
PRO CB  HB2  sing N N 344 
PRO CB  HB3  sing N N 345 
PRO CG  CD   sing N N 346 
PRO CG  HG2  sing N N 347 
PRO CG  HG3  sing N N 348 
PRO CD  HD2  sing N N 349 
PRO CD  HD3  sing N N 350 
PRO OXT HXT  sing N N 351 
SER N   CA   sing N N 352 
SER N   H    sing N N 353 
SER N   H2   sing N N 354 
SER CA  C    sing N N 355 
SER CA  CB   sing N N 356 
SER CA  HA   sing N N 357 
SER C   O    doub N N 358 
SER C   OXT  sing N N 359 
SER CB  OG   sing N N 360 
SER CB  HB2  sing N N 361 
SER CB  HB3  sing N N 362 
SER OG  HG   sing N N 363 
SER OXT HXT  sing N N 364 
SO4 S   O1   doub N N 365 
SO4 S   O2   doub N N 366 
SO4 S   O3   sing N N 367 
SO4 S   O4   sing N N 368 
THR N   CA   sing N N 369 
THR N   H    sing N N 370 
THR N   H2   sing N N 371 
THR CA  C    sing N N 372 
THR CA  CB   sing N N 373 
THR CA  HA   sing N N 374 
THR C   O    doub N N 375 
THR C   OXT  sing N N 376 
THR CB  OG1  sing N N 377 
THR CB  CG2  sing N N 378 
THR CB  HB   sing N N 379 
THR OG1 HG1  sing N N 380 
THR CG2 HG21 sing N N 381 
THR CG2 HG22 sing N N 382 
THR CG2 HG23 sing N N 383 
THR OXT HXT  sing N N 384 
TRP N   CA   sing N N 385 
TRP N   H    sing N N 386 
TRP N   H2   sing N N 387 
TRP CA  C    sing N N 388 
TRP CA  CB   sing N N 389 
TRP CA  HA   sing N N 390 
TRP C   O    doub N N 391 
TRP C   OXT  sing N N 392 
TRP CB  CG   sing N N 393 
TRP CB  HB2  sing N N 394 
TRP CB  HB3  sing N N 395 
TRP CG  CD1  doub Y N 396 
TRP CG  CD2  sing Y N 397 
TRP CD1 NE1  sing Y N 398 
TRP CD1 HD1  sing N N 399 
TRP CD2 CE2  doub Y N 400 
TRP CD2 CE3  sing Y N 401 
TRP NE1 CE2  sing Y N 402 
TRP NE1 HE1  sing N N 403 
TRP CE2 CZ2  sing Y N 404 
TRP CE3 CZ3  doub Y N 405 
TRP CE3 HE3  sing N N 406 
TRP CZ2 CH2  doub Y N 407 
TRP CZ2 HZ2  sing N N 408 
TRP CZ3 CH2  sing Y N 409 
TRP CZ3 HZ3  sing N N 410 
TRP CH2 HH2  sing N N 411 
TRP OXT HXT  sing N N 412 
TYR N   CA   sing N N 413 
TYR N   H    sing N N 414 
TYR N   H2   sing N N 415 
TYR CA  C    sing N N 416 
TYR CA  CB   sing N N 417 
TYR CA  HA   sing N N 418 
TYR C   O    doub N N 419 
TYR C   OXT  sing N N 420 
TYR CB  CG   sing N N 421 
TYR CB  HB2  sing N N 422 
TYR CB  HB3  sing N N 423 
TYR CG  CD1  doub Y N 424 
TYR CG  CD2  sing Y N 425 
TYR CD1 CE1  sing Y N 426 
TYR CD1 HD1  sing N N 427 
TYR CD2 CE2  doub Y N 428 
TYR CD2 HD2  sing N N 429 
TYR CE1 CZ   doub Y N 430 
TYR CE1 HE1  sing N N 431 
TYR CE2 CZ   sing Y N 432 
TYR CE2 HE2  sing N N 433 
TYR CZ  OH   sing N N 434 
TYR OH  HH   sing N N 435 
TYR OXT HXT  sing N N 436 
VAL N   CA   sing N N 437 
VAL N   H    sing N N 438 
VAL N   H2   sing N N 439 
VAL CA  C    sing N N 440 
VAL CA  CB   sing N N 441 
VAL CA  HA   sing N N 442 
VAL C   O    doub N N 443 
VAL C   OXT  sing N N 444 
VAL CB  CG1  sing N N 445 
VAL CB  CG2  sing N N 446 
VAL CB  HB   sing N N 447 
VAL CG1 HG11 sing N N 448 
VAL CG1 HG12 sing N N 449 
VAL CG1 HG13 sing N N 450 
VAL CG2 HG21 sing N N 451 
VAL CG2 HG22 sing N N 452 
VAL CG2 HG23 sing N N 453 
VAL OXT HXT  sing N N 454 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           31970103 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             other 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          Q5ZTY7 
# 
_space_group.name_H-M_alt     'P 62 2 2' 
_space_group.name_Hall        'P 62 2 (x,y,z+1/3)' 
_space_group.IT_number        180 
_space_group.crystal_system   hexagonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8WWG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.007665 
_atom_sites.fract_transf_matrix[1][2]   0.004425 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008851 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008656 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P ? ? 9.51135 5.44231 1.42069  35.72801 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 11  ? 15.021  -12.308 -4.585  1.000 71.880  0 15  GLN A N   1 
ATOM   2    C CA  . GLN A 1 11  ? 15.750  -13.398 -3.943  1.000 71.940  0 15  GLN A CA  1 
ATOM   3    C C   . GLN A 1 11  ? 15.627  -14.691 -4.744  1.000 70.210  0 15  GLN A C   1 
ATOM   4    O O   . GLN A 1 11  ? 14.569  -15.321 -4.757  1.000 69.770  0 15  GLN A O   1 
ATOM   5    C CB  . GLN A 1 11  ? 15.244  -13.617 -2.515  1.000 74.600  0 15  GLN A CB  1 
ATOM   6    C CG  . GLN A 1 11  ? 15.788  -12.620 -1.508  1.000 80.580  0 15  GLN A CG  1 
ATOM   7    C CD  . GLN A 1 11  ? 14.821  -12.344 -0.369  1.000 85.450  0 15  GLN A CD  1 
ATOM   8    O OE1 . GLN A 1 11  ? 13.890  -13.114 -0.126  1.000 85.810  0 15  GLN A OE1 1 
ATOM   9    N NE2 . GLN A 1 11  ? 15.040  -11.241 0.338   1.000 84.600  0 15  GLN A NE2 1 
ATOM   10   N N   . ASP A 1 12  ? 16.716  -15.083 -5.412  1.000 66.900  0 16  ASP A N   1 
ATOM   11   C CA  . ASP A 1 12  ? 16.751  -16.330 -6.179  1.000 62.710  0 16  ASP A CA  1 
ATOM   12   C C   . ASP A 1 12  ? 17.134  -17.503 -5.274  1.000 58.650  0 16  ASP A C   1 
ATOM   13   O O   . ASP A 1 12  ? 18.107  -18.224 -5.493  1.000 60.520  0 16  ASP A O   1 
ATOM   14   C CB  . ASP A 1 12  ? 17.703  -16.204 -7.360  1.000 59.280  0 16  ASP A CB  1 
ATOM   15   C CG  . ASP A 1 12  ? 17.524  -17.319 -8.368  1.000 55.950  0 16  ASP A CG  1 
ATOM   16   O OD1 . ASP A 1 12  ? 16.470  -17.989 -8.341  1.000 57.840  0 16  ASP A OD1 1 
ATOM   17   O OD2 . ASP A 1 12  ? 18.443  -17.539 -9.178  1.000 59.620  0 16  ASP A OD2 1 
ATOM   18   N N   . TYR A 1 13  ? 16.330  -17.678 -4.233  1.000 56.040  0 17  TYR A N   1 
ATOM   19   C CA  . TYR A 1 13  ? 16.463  -18.782 -3.297  1.000 53.450  0 17  TYR A CA  1 
ATOM   20   C C   . TYR A 1 13  ? 15.170  -18.845 -2.499  1.000 54.090  0 17  TYR A C   1 
ATOM   21   O O   . TYR A 1 13  ? 14.378  -17.901 -2.500  1.000 53.000  0 17  TYR A O   1 
ATOM   22   C CB  . TYR A 1 13  ? 17.681  -18.602 -2.374  1.000 54.230  0 17  TYR A CB  1 
ATOM   23   C CG  . TYR A 1 13  ? 17.616  -17.376 -1.481  1.000 57.110  0 17  TYR A CG  1 
ATOM   24   C CD1 . TYR A 1 13  ? 16.897  -17.394 -0.295  1.000 59.090  0 17  TYR A CD1 1 
ATOM   25   C CD2 . TYR A 1 13  ? 18.283  -16.207 -1.819  1.000 59.620  0 17  TYR A CD2 1 
ATOM   26   C CE1 . TYR A 1 13  ? 16.836  -16.285 0.521   1.000 61.820  0 17  TYR A CE1 1 
ATOM   27   C CE2 . TYR A 1 13  ? 18.229  -15.087 -1.004  1.000 62.910  0 17  TYR A CE2 1 
ATOM   28   C CZ  . TYR A 1 13  ? 17.503  -15.136 0.167   1.000 62.070  0 17  TYR A CZ  1 
ATOM   29   O OH  . TYR A 1 13  ? 17.427  -14.041 0.995   1.000 68.330  0 17  TYR A OH  1 
ATOM   30   N N   . LYS A 1 14  ? 14.957  -19.964 -1.818  1.000 50.760  0 18  LYS A N   1 
ATOM   31   C CA  . LYS A 1 14  ? 13.875  -20.047 -0.843  1.000 47.310  0 18  LYS A CA  1 
ATOM   32   C C   . LYS A 1 14  ? 14.350  -20.911 0.310   1.000 59.470  0 18  LYS A C   1 
ATOM   33   O O   . LYS A 1 14  ? 14.601  -22.106 0.121   1.000 50.160  0 18  LYS A O   1 
ATOM   34   C CB  . LYS A 1 14  ? 12.590  -20.607 -1.449  1.000 52.030  0 18  LYS A CB  1 
ATOM   35   C CG  . LYS A 1 14  ? 11.392  -20.419 -0.512  1.000 60.190  0 18  LYS A CG  1 
ATOM   36   C CD  . LYS A 1 14  ? 10.060  -20.634 -1.191  1.000 68.160  0 18  LYS A CD  1 
ATOM   37   C CE  . LYS A 1 14  ? 8.940   -20.744 -0.159  1.000 74.220  0 18  LYS A CE  1 
ATOM   38   N NZ  . LYS A 1 14  ? 8.730   -19.464 0.573   1.000 76.140  0 18  LYS A NZ  1 
ATOM   39   N N   . VAL A 1 15  ? 14.480  -20.302 1.493   1.000 46.490  0 19  VAL A N   1 
ATOM   40   C CA  . VAL A 1 15  ? 14.896  -20.995 2.709   1.000 52.400  0 19  VAL A CA  1 
ATOM   41   C C   . VAL A 1 15  ? 14.012  -20.526 3.859   1.000 54.170  0 19  VAL A C   1 
ATOM   42   O O   . VAL A 1 15  ? 13.226  -19.585 3.729   1.000 54.350  0 19  VAL A O   1 
ATOM   43   C CB  . VAL A 1 15  ? 16.387  -20.757 3.045   1.000 46.560  0 19  VAL A CB  1 
ATOM   44   C CG1 . VAL A 1 15  ? 17.268  -21.168 1.880   1.000 53.160  0 19  VAL A CG1 1 
ATOM   45   C CG2 . VAL A 1 15  ? 16.623  -19.296 3.413   1.000 54.250  0 19  VAL A CG2 1 
ATOM   46   N N   . ALA A 1 16  ? 14.169  -21.189 5.006   1.000 51.050  0 20  ALA A N   1 
ATOM   47   C CA  . ALA A 1 16  ? 13.328  -20.962 6.176   1.000 58.590  0 20  ALA A CA  1 
ATOM   48   C C   . ALA A 1 16  ? 13.624  -19.624 6.847   1.000 57.840  0 20  ALA A C   1 
ATOM   49   O O   . ALA A 1 16  ? 12.767  -18.737 6.863   1.000 65.640  0 20  ALA A O   1 
ATOM   50   C CB  . ALA A 1 16  ? 13.499  -22.109 7.179   1.000 55.220  0 20  ALA A CB  1 
ATOM   51   N N   . GLU A 1 17  ? 14.816  -19.478 7.429   1.000 56.580  0 21  GLU A N   1 
ATOM   52   C CA  . GLU A 1 17  ? 15.258  -18.216 8.018   1.000 62.500  0 21  GLU A CA  1 
ATOM   53   C C   . GLU A 1 17  ? 16.676  -17.951 7.548   1.000 59.980  0 21  GLU A C   1 
ATOM   54   O O   . GLU A 1 17  ? 17.590  -18.718 7.870   1.000 57.170  0 21  GLU A O   1 
ATOM   55   C CB  . GLU A 1 17  ? 15.215  -18.234 9.550   1.000 69.910  0 21  GLU A CB  1 
ATOM   56   C CG  . GLU A 1 17  ? 13.977  -18.837 10.168  1.000 84.700  0 21  GLU A CG  1 
ATOM   57   C CD  . GLU A 1 17  ? 14.287  -19.569 11.459  1.000 92.110  0 21  GLU A CD  1 
ATOM   58   O OE1 . GLU A 1 17  ? 13.898  -20.752 11.584  1.000 93.180  0 21  GLU A OE1 1 
ATOM   59   O OE2 . GLU A 1 17  ? 14.932  -18.962 12.345  1.000 89.220  0 21  GLU A OE2 1 
ATOM   60   N N   . ILE A 1 18  ? 16.857  -16.869 6.789   1.000 48.390  0 22  ILE A N   1 
ATOM   61   C CA  . ILE A 1 18  ? 18.172  -16.520 6.266   1.000 56.560  0 22  ILE A CA  1 
ATOM   62   C C   . ILE A 1 18  ? 19.134  -16.137 7.386   1.000 59.060  0 22  ILE A C   1 
ATOM   63   O O   . ILE A 1 18  ? 20.353  -16.272 7.225   1.000 64.300  0 22  ILE A O   1 
ATOM   64   C CB  . ILE A 1 18  ? 18.028  -15.390 5.221   1.000 57.440  0 22  ILE A CB  1 
ATOM   65   C CG1 . ILE A 1 18  ? 19.359  -15.099 4.518   1.000 59.460  0 22  ILE A CG1 1 
ATOM   66   C CG2 . ILE A 1 18  ? 17.471  -14.128 5.868   1.000 60.790  0 22  ILE A CG2 1 
ATOM   67   C CD1 . ILE A 1 18  ? 19.666  -16.041 3.357   1.000 64.170  0 22  ILE A CD1 1 
ATOM   68   N N   . SER A 1 19  ? 18.618  -15.692 8.534   1.000 51.690  0 23  SER A N   1 
ATOM   69   C CA  . SER A 1 19  ? 19.467  -15.260 9.641   1.000 53.030  0 23  SER A CA  1 
ATOM   70   C C   . SER A 1 19  ? 20.179  -16.420 10.326  1.000 52.560  0 23  SER A C   1 
ATOM   71   O O   . SER A 1 19  ? 21.043  -16.183 11.173  1.000 51.310  0 23  SER A O   1 
ATOM   72   C CB  . SER A 1 19  ? 18.640  -14.498 10.675  1.000 57.860  0 23  SER A CB  1 
ATOM   73   O OG  . SER A 1 19  ? 17.535  -15.275 11.106  1.000 59.280  0 23  SER A OG  1 
ATOM   74   N N   . LEU A 1 20  ? 19.830  -17.659 10.003  1.000 49.040  0 24  LEU A N   1 
ATOM   75   C CA  . LEU A 1 20  ? 20.599  -18.787 10.512  1.000 49.690  0 24  LEU A CA  1 
ATOM   76   C C   . LEU A 1 20  ? 21.915  -18.984 9.773   1.000 49.100  0 24  LEU A C   1 
ATOM   77   O O   . LEU A 1 20  ? 22.636  -19.938 10.090  1.000 44.800  0 24  LEU A O   1 
ATOM   78   C CB  . LEU A 1 20  ? 19.777  -20.070 10.429  1.000 53.280  0 24  LEU A CB  1 
ATOM   79   C CG  . LEU A 1 20  ? 18.399  -20.057 11.074  1.000 49.930  0 24  LEU A CG  1 
ATOM   80   C CD1 . LEU A 1 20  ? 17.675  -21.325 10.682  1.000 47.610  0 24  LEU A CD1 1 
ATOM   81   C CD2 . LEU A 1 20  ? 18.516  -19.920 12.589  1.000 47.980  0 24  LEU A CD2 1 
ATOM   82   N N   . ALA A 1 21  ? 22.245  -18.096 8.825   1.000 46.160  0 25  ALA A N   1 
ATOM   83   C CA  . ALA A 1 21  ? 23.405  -18.298 7.963   1.000 47.420  0 25  ALA A CA  1 
ATOM   84   C C   . ALA A 1 21  ? 24.710  -18.289 8.752   1.000 56.230  0 25  ALA A C   1 
ATOM   85   O O   . ALA A 1 21  ? 25.644  -19.026 8.419   1.000 50.400  0 25  ALA A O   1 
ATOM   86   C CB  . ALA A 1 21  ? 23.446  -17.226 6.872   1.000 45.310  0 25  ALA A CB  1 
ATOM   87   N N   . ASP A 1 22  ? 24.808  -17.451 9.788   1.000 46.540  0 26  ASP A N   1 
ATOM   88   C CA  . ASP A 1 22  ? 26.073  -17.359 10.509  1.000 48.210  0 26  ASP A CA  1 
ATOM   89   C C   . ASP A 1 22  ? 26.342  -18.632 11.302  1.000 51.620  0 26  ASP A C   1 
ATOM   90   O O   . ASP A 1 22  ? 27.488  -19.101 11.367  1.000 47.760  0 26  ASP A O   1 
ATOM   91   C CB  . ASP A 1 22  ? 26.080  -16.130 11.416  1.000 55.680  0 26  ASP A CB  1 
ATOM   92   C CG  . ASP A 1 22  ? 26.559  -14.876 10.692  1.000 74.040  0 26  ASP A CG  1 
ATOM   93   O OD1 . ASP A 1 22  ? 26.752  -14.927 9.455   1.000 78.150  0 26  ASP A OD1 1 
ATOM   94   O OD2 . ASP A 1 22  ? 26.748  -13.841 11.363  1.000 84.940  0 26  ASP A OD2 1 
ATOM   95   N N   . TRP A 1 23  ? 25.294  -19.224 11.882  1.000 44.140  0 27  TRP A N   1 
ATOM   96   C CA  . TRP A 1 23  ? 25.433  -20.534 12.511  1.000 47.740  0 27  TRP A CA  1 
ATOM   97   C C   . TRP A 1 23  ? 25.859  -21.588 11.490  1.000 51.430  0 27  TRP A C   1 
ATOM   98   O O   . TRP A 1 23  ? 26.731  -22.418 11.773  1.000 44.510  0 27  TRP A O   1 
ATOM   99   C CB  . TRP A 1 23  ? 24.116  -20.913 13.199  1.000 48.420  0 27  TRP A CB  1 
ATOM   100  C CG  . TRP A 1 23  ? 24.021  -22.321 13.752  1.000 48.150  0 27  TRP A CG  1 
ATOM   101  C CD1 . TRP A 1 23  ? 25.047  -23.123 14.187  1.000 46.400  0 27  TRP A CD1 1 
ATOM   102  C CD2 . TRP A 1 23  ? 22.817  -23.077 13.942  1.000 50.330  0 27  TRP A CD2 1 
ATOM   103  N NE1 . TRP A 1 23  ? 24.550  -24.339 14.620  1.000 44.510  0 27  TRP A NE1 1 
ATOM   104  C CE2 . TRP A 1 23  ? 23.185  -24.331 14.482  1.000 48.110  0 27  TRP A CE2 1 
ATOM   105  C CE3 . TRP A 1 23  ? 21.462  -22.815 13.704  1.000 46.560  0 27  TRP A CE3 1 
ATOM   106  C CZ2 . TRP A 1 23  ? 22.244  -25.317 14.784  1.000 50.720  0 27  TRP A CZ2 1 
ATOM   107  C CZ3 . TRP A 1 23  ? 20.530  -23.791 14.006  1.000 44.340  0 27  TRP A CZ3 1 
ATOM   108  C CH2 . TRP A 1 23  ? 20.924  -25.029 14.539  1.000 53.160  0 27  TRP A CH2 1 
ATOM   109  N N   . GLY A 1 24  ? 25.278  -21.556 10.286  1.000 46.660  0 28  GLY A N   1 
ATOM   110  C CA  . GLY A 1 24  ? 25.662  -22.525 9.267   1.000 45.910  0 28  GLY A CA  1 
ATOM   111  C C   . GLY A 1 24  ? 27.114  -22.380 8.850   1.000 51.570  0 28  GLY A C   1 
ATOM   112  O O   . GLY A 1 24  ? 27.833  -23.375 8.698   1.000 49.530  0 28  GLY A O   1 
ATOM   113  N N   . ARG A 1 25  ? 27.566  -21.137 8.668   1.000 44.060  0 29  ARG A N   1 
ATOM   114  C CA  . ARG A 1 25  ? 28.964  -20.890 8.339   1.000 42.250  0 29  ARG A CA  1 
ATOM   115  C C   . ARG A 1 25  ? 29.893  -21.490 9.387   1.000 45.230  0 29  ARG A C   1 
ATOM   116  O O   . ARG A 1 25  ? 30.925  -22.080 9.044   1.000 46.560  0 29  ARG A O   1 
ATOM   117  C CB  . ARG A 1 25  ? 29.219  -19.387 8.209   1.000 43.640  0 29  ARG A CB  1 
ATOM   118  C CG  . ARG A 1 25  ? 30.606  -19.042 7.702   1.000 60.100  0 29  ARG A CG  1 
ATOM   119  C CD  . ARG A 1 25  ? 30.983  -19.923 6.521   1.000 71.500  0 29  ARG A CD  1 
ATOM   120  N NE  . ARG A 1 25  ? 30.231  -19.572 5.321   1.000 72.310  0 29  ARG A NE  1 
ATOM   121  C CZ  . ARG A 1 25  ? 30.275  -20.256 4.185   1.000 67.080  0 29  ARG A CZ  1 
ATOM   122  N NH1 . ARG A 1 25  ? 31.032  -21.343 4.095   1.000 58.390  0 29  ARG A NH1 1 
ATOM   123  N NH2 . ARG A 1 25  ? 29.563  -19.855 3.140   1.000 70.570  0 29  ARG A NH2 1 
ATOM   124  N N   . LYS A 1 26  ? 29.558  -21.328 10.670  1.000 44.630  0 30  LYS A N   1 
ATOM   125  C CA  . LYS A 1 26  ? 30.426  -21.848 11.725  1.000 46.270  0 30  LYS A CA  1 
ATOM   126  C C   . LYS A 1 26  ? 30.551  -23.364 11.629  1.000 43.090  0 30  LYS A C   1 
ATOM   127  O O   . LYS A 1 26  ? 31.650  -23.916 11.762  1.000 43.640  0 30  LYS A O   1 
ATOM   128  C CB  . LYS A 1 26  ? 29.895  -21.443 13.105  1.000 42.740  0 30  LYS A CB  1 
ATOM   129  C CG  . LYS A 1 26  ? 30.159  -19.980 13.523  1.000 46.310  0 30  LYS A CG  1 
ATOM   130  C CD  . LYS A 1 26  ? 29.377  -19.642 14.801  1.000 46.730  0 30  LYS A CD  1 
ATOM   131  C CE  . LYS A 1 26  ? 29.484  -18.179 15.179  1.000 51.770  0 30  LYS A CE  1 
ATOM   132  N NZ  . LYS A 1 26  ? 28.875  -17.892 16.521  1.000 46.980  0 30  LYS A NZ  1 
ATOM   133  N N   . GLU A 1 27  ? 29.435  -24.057 11.396  1.000 41.710  0 31  GLU A N   1 
ATOM   134  C CA  . GLU A 1 27  ? 29.489  -25.514 11.323  1.000 45.650  0 31  GLU A CA  1 
ATOM   135  C C   . GLU A 1 27  ? 30.094  -25.987 10.012  1.000 43.210  0 31  GLU A C   1 
ATOM   136  O O   . GLU A 1 27  ? 30.686  -27.075 9.951   1.000 41.400  0 31  GLU A O   1 
ATOM   137  C CB  . GLU A 1 27  ? 28.092  -26.091 11.516  1.000 46.780  0 31  GLU A CB  1 
ATOM   138  C CG  . GLU A 1 27  ? 27.553  -25.844 12.913  1.000 47.510  0 31  GLU A CG  1 
ATOM   139  C CD  . GLU A 1 27  ? 26.450  -26.802 13.287  1.000 49.610  0 31  GLU A CD  1 
ATOM   140  O OE1 . GLU A 1 27  ? 25.889  -27.426 12.366  1.000 51.510  0 31  GLU A OE1 1 
ATOM   141  O OE2 . GLU A 1 27  ? 26.140  -26.918 14.494  1.000 43.340  0 31  GLU A OE2 1 
ATOM   142  N N   . ILE A 1 28  ? 29.952  -25.191 8.958   1.000 39.270  0 32  ILE A N   1 
ATOM   143  C CA  . ILE A 1 28  ? 30.622  -25.488 7.702   1.000 43.960  0 32  ILE A CA  1 
ATOM   144  C C   . ILE A 1 28  ? 32.134  -25.397 7.870   1.000 42.430  0 32  ILE A C   1 
ATOM   145  O O   . ILE A 1 28  ? 32.876  -26.259 7.381   1.000 41.060  0 32  ILE A O   1 
ATOM   146  C CB  . ILE A 1 28  ? 30.105  -24.540 6.606   1.000 45.270  0 32  ILE A CB  1 
ATOM   147  C CG1 . ILE A 1 28  ? 28.691  -24.960 6.186   1.000 38.350  0 32  ILE A CG1 1 
ATOM   148  C CG2 . ILE A 1 28  ? 31.062  -24.494 5.427   1.000 41.680  0 32  ILE A CG2 1 
ATOM   149  C CD1 . ILE A 1 28  ? 27.958  -23.876 5.410   1.000 38.920  0 32  ILE A CD1 1 
ATOM   150  N N   . ALA A 1 29  ? 32.616  -24.360 8.567   1.000 41.180  0 33  ALA A N   1 
ATOM   151  C CA  . ALA A 1 29  ? 34.053  -24.242 8.815   1.000 44.630  0 33  ALA A CA  1 
ATOM   152  C C   . ALA A 1 29  ? 34.586  -25.469 9.553   1.000 43.820  0 33  ALA A C   1 
ATOM   153  O O   . ALA A 1 29  ? 35.668  -25.973 9.229   1.000 39.560  0 33  ALA A O   1 
ATOM   154  C CB  . ALA A 1 29  ? 34.354  -22.965 9.604   1.000 44.160  0 33  ALA A CB  1 
ATOM   155  N N   . ILE A 1 30  ? 33.827  -25.974 10.532  1.000 41.890  0 34  ILE A N   1 
ATOM   156  C CA  . ILE A 1 30  ? 34.227  -27.183 11.255  1.000 42.680  0 34  ILE A CA  1 
ATOM   157  C C   . ILE A 1 30  ? 34.258  -28.381 10.310  1.000 44.970  0 34  ILE A C   1 
ATOM   158  O O   . ILE A 1 30  ? 35.224  -29.155 10.289  1.000 41.650  0 34  ILE A O   1 
ATOM   159  C CB  . ILE A 1 30  ? 33.283  -27.441 12.445  1.000 46.350  0 34  ILE A CB  1 
ATOM   160  C CG1 . ILE A 1 30  ? 33.389  -26.324 13.487  1.000 46.700  0 34  ILE A CG1 1 
ATOM   161  C CG2 . ILE A 1 30  ? 33.593  -28.792 13.092  1.000 48.560  0 34  ILE A CG2 1 
ATOM   162  C CD1 . ILE A 1 30  ? 32.226  -26.327 14.494  1.000 46.140  0 34  ILE A CD1 1 
ATOM   163  N N   . ALA A 1 31  ? 33.197  -28.543 9.503   1.000 39.520  0 35  ALA A N   1 
ATOM   164  C CA  . ALA A 1 31  ? 33.090  -29.693 8.611   1.000 41.700  0 35  ALA A CA  1 
ATOM   165  C C   . ALA A 1 31  ? 34.227  -29.726 7.590   1.000 39.090  0 35  ALA A C   1 
ATOM   166  O O   . ALA A 1 31  ? 34.725  -30.806 7.250   1.000 41.790  0 35  ALA A O   1 
ATOM   167  C CB  . ALA A 1 31  ? 31.726  -29.687 7.913   1.000 36.150  0 35  ALA A CB  1 
ATOM   168  N N   . GLU A 1 32  ? 34.666  -28.558 7.104   1.000 41.840  0 36  GLU A N   1 
ATOM   169  C CA  . GLU A 1 32  ? 35.792  -28.519 6.170   1.000 42.880  0 36  GLU A CA  1 
ATOM   170  C C   . GLU A 1 32  ? 37.012  -29.252 6.730   1.000 41.460  0 36  GLU A C   1 
ATOM   171  O O   . GLU A 1 32  ? 37.719  -29.953 5.992   1.000 40.600  0 36  GLU A O   1 
ATOM   172  C CB  . GLU A 1 32  ? 36.145  -27.065 5.817   1.000 44.270  0 36  GLU A CB  1 
ATOM   173  C CG  . GLU A 1 32  ? 35.104  -26.413 4.884   1.000 37.210  0 36  GLU A CG  1 
ATOM   174  C CD  . GLU A 1 32  ? 35.327  -24.928 4.666   1.000 47.950  0 36  GLU A CD  1 
ATOM   175  O OE1 . GLU A 1 32  ? 34.459  -24.297 4.026   1.000 49.240  0 36  GLU A OE1 1 
ATOM   176  O OE2 . GLU A 1 32  ? 36.358  -24.394 5.128   1.000 46.230  0 36  GLU A OE2 1 
ATOM   177  N N   . THR A 1 33  ? 37.271  -29.108 8.033   1.000 35.460  0 37  THR A N   1 
ATOM   178  C CA  . THR A 1 33  ? 38.423  -29.766 8.634   1.000 41.360  0 37  THR A CA  1 
ATOM   179  C C   . THR A 1 33  ? 38.239  -31.268 8.773   1.000 44.930  0 37  THR A C   1 
ATOM   180  O O   . THR A 1 33  ? 39.222  -31.957 9.059   1.000 42.830  0 37  THR A O   1 
ATOM   181  C CB  . THR A 1 33  ? 38.751  -29.164 10.009  1.000 42.770  0 37  THR A CB  1 
ATOM   182  O OG1 . THR A 1 33  ? 37.808  -29.617 10.984  1.000 40.680  0 37  THR A OG1 1 
ATOM   183  C CG2 . THR A 1 33  ? 38.751  -27.632 9.954   1.000 48.990  0 37  THR A CG2 1 
ATOM   184  N N   . GLU A 1 34  ? 37.018  -31.784 8.584   1.000 35.250  0 38  GLU A N   1 
ATOM   185  C CA  . GLU A 1 34  ? 36.728  -33.214 8.581   1.000 39.770  0 38  GLU A CA  1 
ATOM   186  C C   . GLU A 1 34  ? 36.570  -33.776 7.177   1.000 37.110  0 38  GLU A C   1 
ATOM   187  O O   . GLU A 1 34  ? 36.313  -34.973 7.030   1.000 35.470  0 38  GLU A O   1 
ATOM   188  C CB  . GLU A 1 34  ? 35.445  -33.504 9.370   1.000 43.780  0 38  GLU A CB  1 
ATOM   189  C CG  . GLU A 1 34  ? 35.566  -33.356 10.869  1.000 50.350  0 38  GLU A CG  1 
ATOM   190  C CD  . GLU A 1 34  ? 36.267  -34.535 11.500  1.000 48.250  0 38  GLU A CD  1 
ATOM   191  O OE1 . GLU A 1 34  ? 37.423  -34.370 11.948  1.000 45.690  0 38  GLU A OE1 1 
ATOM   192  O OE2 . GLU A 1 34  ? 35.662  -35.622 11.528  1.000 40.990  0 38  GLU A OE2 1 
ATOM   193  N N   . MET A 1 35  ? 36.724  -32.949 6.145   1.000 36.910  0 39  MET A N   1 
ATOM   194  C CA  . MET A 1 35  ? 36.444  -33.337 4.767   1.000 36.460  0 39  MET A CA  1 
ATOM   195  C C   . MET A 1 35  ? 37.665  -33.075 3.890   1.000 41.070  0 39  MET A C   1 
ATOM   196  O O   . MET A 1 35  ? 37.639  -32.206 3.007   1.000 40.230  0 39  MET A O   1 
ATOM   197  C CB  . MET A 1 35  ? 35.209  -32.599 4.253   1.000 42.230  0 39  MET A CB  1 
ATOM   198  C CG  . MET A 1 35  ? 33.986  -32.903 5.096   1.000 40.620  0 39  MET A CG  1 
ATOM   199  S SD  . MET A 1 35  ? 32.484  -32.021 4.640   1.000 38.480  0 39  MET A SD  1 
ATOM   200  C CE  . MET A 1 35  ? 31.794  -33.174 3.472   1.000 35.910  0 39  MET A CE  1 
ATOM   201  N N   . PRO A 1 36  ? 38.750  -33.832 4.093   1.000 41.350  0 40  PRO A N   1 
ATOM   202  C CA  . PRO A 1 36  ? 39.996  -33.530 3.366   1.000 39.800  0 40  PRO A CA  1 
ATOM   203  C C   . PRO A 1 36  ? 39.928  -33.849 1.887   1.000 39.740  0 40  PRO A C   1 
ATOM   204  O O   . PRO A 1 36  ? 40.697  -33.261 1.114   1.000 38.820  0 40  PRO A O   1 
ATOM   205  C CB  . PRO A 1 36  ? 41.043  -34.398 4.081   1.000 41.630  0 40  PRO A CB  1 
ATOM   206  C CG  . PRO A 1 36  ? 40.258  -35.523 4.681   1.000 37.280  0 40  PRO A CG  1 
ATOM   207  C CD  . PRO A 1 36  ? 38.906  -34.956 5.032   1.000 35.430  0 40  PRO A CD  1 
ATOM   208  N N   . GLY A 1 37  ? 39.046  -34.762 1.473   1.000 34.390  0 41  GLY A N   1 
ATOM   209  C CA  . GLY A 1 37  ? 38.890  -35.049 0.052   1.000 39.730  0 41  GLY A CA  1 
ATOM   210  C C   . GLY A 1 37  ? 38.397  -33.846 -0.729  1.000 41.840  0 41  GLY A C   1 
ATOM   211  O O   . GLY A 1 37  ? 38.947  -33.498 -1.779  1.000 39.810  0 41  GLY A O   1 
ATOM   212  N N   . LEU A 1 38  ? 37.348  -33.192 -0.221  1.000 37.200  0 42  LEU A N   1 
ATOM   213  C CA  . LEU A 1 38  ? 36.831  -32.002 -0.880  1.000 36.050  0 42  LEU A CA  1 
ATOM   214  C C   . LEU A 1 38  ? 37.838  -30.857 -0.816  1.000 38.350  0 42  LEU A C   1 
ATOM   215  O O   . LEU A 1 38  ? 38.059  -30.172 -1.820  1.000 43.180  0 42  LEU A O   1 
ATOM   216  C CB  . LEU A 1 38  ? 35.489  -31.594 -0.262  1.000 37.030  0 42  LEU A CB  1 
ATOM   217  C CG  . LEU A 1 38  ? 34.277  -32.491 -0.563  1.000 38.400  0 42  LEU A CG  1 
ATOM   218  C CD1 . LEU A 1 38  ? 33.016  -31.986 0.154   1.000 38.250  0 42  LEU A CD1 1 
ATOM   219  C CD2 . LEU A 1 38  ? 34.025  -32.594 -2.079  1.000 41.170  0 42  LEU A CD2 1 
ATOM   220  N N   . MET A 1 39  ? 38.469  -30.633 0.348   1.000 38.450  0 43  MET A N   1 
ATOM   221  C CA  . MET A 1 39  ? 39.435  -29.542 0.436   1.000 46.030  0 43  MET A CA  1 
ATOM   222  C C   . MET A 1 39  ? 40.639  -29.790 -0.463  1.000 44.060  0 43  MET A C   1 
ATOM   223  O O   . MET A 1 39  ? 41.227  -28.836 -0.985  1.000 43.320  0 43  MET A O   1 
ATOM   224  C CB  . MET A 1 39  ? 39.891  -29.331 1.880   1.000 46.700  0 43  MET A CB  1 
ATOM   225  C CG  . MET A 1 39  ? 38.764  -28.983 2.860   1.000 52.820  0 43  MET A CG  1 
ATOM   226  S SD  . MET A 1 39  ? 37.707  -27.619 2.329   1.000 45.370  0 43  MET A SD  1 
ATOM   227  C CE  . MET A 1 39  ? 38.762  -26.221 2.680   1.000 48.770  0 43  MET A CE  1 
ATOM   228  N N   . ALA A 1 40  ? 41.022  -31.054 -0.650  1.000 38.990  0 44  ALA A N   1 
ATOM   229  C CA  . ALA A 1 40  ? 42.127  -31.363 -1.554  1.000 44.150  0 44  ALA A CA  1 
ATOM   230  C C   . ALA A 1 40  ? 41.759  -31.070 -3.004  1.000 43.630  0 44  ALA A C   1 
ATOM   231  O O   . ALA A 1 40  ? 42.611  -30.631 -3.786  1.000 39.690  0 44  ALA A O   1 
ATOM   232  C CB  . ALA A 1 40  ? 42.548  -32.822 -1.396  1.000 33.030  0 44  ALA A CB  1 
ATOM   233  N N   . LEU A 1 41  ? 40.503  -31.321 -3.391  1.000 40.440  0 45  LEU A N   1 
ATOM   234  C CA  . LEU A 1 41  ? 40.088  -31.009 -4.757  1.000 42.090  0 45  LEU A CA  1 
ATOM   235  C C   . LEU A 1 41  ? 40.084  -29.507 -4.995  1.000 42.330  0 45  LEU A C   1 
ATOM   236  O O   . LEU A 1 41  ? 40.442  -29.047 -6.086  1.000 42.340  0 45  LEU A O   1 
ATOM   237  C CB  . LEU A 1 41  ? 38.704  -31.595 -5.049  1.000 43.330  0 45  LEU A CB  1 
ATOM   238  C CG  . LEU A 1 41  ? 38.563  -33.119 -5.093  1.000 45.370  0 45  LEU A CG  1 
ATOM   239  C CD1 . LEU A 1 41  ? 37.141  -33.511 -5.506  1.000 38.320  0 45  LEU A CD1 1 
ATOM   240  C CD2 . LEU A 1 41  ? 39.601  -33.777 -5.991  1.000 43.840  0 45  LEU A CD2 1 
ATOM   241  N N   . ARG A 1 42  ? 39.668  -28.724 -3.993  1.000 40.130  0 46  ARG A N   1 
ATOM   242  C CA  . ARG A 1 42  ? 39.816  -27.274 -4.095  1.000 41.540  0 46  ARG A CA  1 
ATOM   243  C C   . ARG A 1 42  ? 41.274  -26.890 -4.308  1.000 48.660  0 46  ARG A C   1 
ATOM   244  O O   . ARG A 1 42  ? 41.600  -26.103 -5.207  1.000 46.710  0 46  ARG A O   1 
ATOM   245  C CB  . ARG A 1 42  ? 39.266  -26.590 -2.846  1.000 43.800  0 46  ARG A CB  1 
ATOM   246  C CG  . ARG A 1 42  ? 37.796  -26.871 -2.571  1.000 40.610  0 46  ARG A CG  1 
ATOM   247  C CD  . ARG A 1 42  ? 37.302  -25.993 -1.444  1.000 42.470  0 46  ARG A CD  1 
ATOM   248  N NE  . ARG A 1 42  ? 35.944  -26.352 -1.044  1.000 43.530  0 46  ARG A NE  1 
ATOM   249  C CZ  . ARG A 1 42  ? 35.299  -25.767 -0.047  1.000 47.980  0 46  ARG A CZ  1 
ATOM   250  N NH1 . ARG A 1 42  ? 35.899  -24.801 0.641   1.000 52.370  0 46  ARG A NH1 1 
ATOM   251  N NH2 . ARG A 1 42  ? 34.069  -26.149 0.263   1.000 46.410  0 46  ARG A NH2 1 
ATOM   252  N N   . GLU A 1 43  ? 42.169  -27.436 -3.485  1.000 42.770  0 47  GLU A N   1 
ATOM   253  C CA  . GLU A 1 43  ? 43.580  -27.085 -3.609  1.000 49.070  0 47  GLU A CA  1 
ATOM   254  C C   . GLU A 1 43  ? 44.131  -27.512 -4.965  1.000 48.480  0 47  GLU A C   1 
ATOM   255  O O   . GLU A 1 43  ? 44.911  -26.781 -5.586  1.000 47.380  0 47  GLU A O   1 
ATOM   256  C CB  . GLU A 1 43  ? 44.378  -27.716 -2.464  1.000 42.710  0 47  GLU A CB  1 
ATOM   257  C CG  . GLU A 1 43  ? 45.880  -27.734 -2.693  1.000 60.100  0 47  GLU A CG  1 
ATOM   258  C CD  . GLU A 1 43  ? 46.472  -26.342 -2.787  1.000 77.820  0 47  GLU A CD  1 
ATOM   259  O OE1 . GLU A 1 43  ? 45.966  -25.432 -2.095  1.000 82.470  0 47  GLU A OE1 1 
ATOM   260  O OE2 . GLU A 1 43  ? 47.446  -26.157 -3.549  1.000 83.810  0 47  GLU A OE2 1 
ATOM   261  N N   . GLU A 1 44  ? 43.714  -28.680 -5.457  1.000 44.000  0 48  GLU A N   1 
ATOM   262  C CA  . GLU A 1 44  ? 44.205  -29.154 -6.749  1.000 44.690  0 48  GLU A CA  1 
ATOM   263  C C   . GLU A 1 44  ? 43.616  -28.365 -7.920  1.000 49.130  0 48  GLU A C   1 
ATOM   264  O O   . GLU A 1 44  ? 44.306  -28.124 -8.915  1.000 42.020  0 48  GLU A O   1 
ATOM   265  C CB  . GLU A 1 44  ? 43.893  -30.643 -6.924  1.000 44.510  0 48  GLU A CB  1 
ATOM   266  C CG  . GLU A 1 44  ? 44.414  -31.196 -8.245  1.000 46.530  0 48  GLU A CG  1 
ATOM   267  C CD  . GLU A 1 44  ? 44.199  -32.687 -8.407  1.000 51.550  0 48  GLU A CD  1 
ATOM   268  O OE1 . GLU A 1 44  ? 43.504  -33.291 -7.566  1.000 54.040  0 48  GLU A OE1 1 
ATOM   269  O OE2 . GLU A 1 44  ? 44.741  -33.261 -9.378  1.000 51.290  0 48  GLU A OE2 1 
ATOM   270  N N   . PHE A 1 45  ? 42.337  -27.979 -7.843  1.000 43.930  0 49  PHE A N   1 
ATOM   271  C CA  . PHE A 1 45  ? 41.600  -27.581 -9.036  1.000 49.320  0 49  PHE A CA  1 
ATOM   272  C C   . PHE A 1 45  ? 41.039  -26.165 -9.030  1.000 49.600  0 49  PHE A C   1 
ATOM   273  O O   . PHE A 1 45  ? 40.594  -25.703 -10.087 1.000 49.450  0 49  PHE A O   1 
ATOM   274  C CB  . PHE A 1 45  ? 40.425  -28.539 -9.280  1.000 47.380  0 49  PHE A CB  1 
ATOM   275  C CG  . PHE A 1 45  ? 40.831  -29.875 -9.805  1.000 44.480  0 49  PHE A CG  1 
ATOM   276  C CD1 . PHE A 1 45  ? 41.529  -29.979 -10.997 1.000 48.920  0 49  PHE A CD1 1 
ATOM   277  C CD2 . PHE A 1 45  ? 40.512  -31.028 -9.110  1.000 46.990  0 49  PHE A CD2 1 
ATOM   278  C CE1 . PHE A 1 45  ? 41.900  -31.210 -11.489 1.000 49.930  0 49  PHE A CE1 1 
ATOM   279  C CE2 . PHE A 1 45  ? 40.885  -32.269 -9.592  1.000 49.560  0 49  PHE A CE2 1 
ATOM   280  C CZ  . PHE A 1 45  ? 41.578  -32.359 -10.788 1.000 47.630  0 49  PHE A CZ  1 
ATOM   281  N N   . SER A 1 46  ? 41.024  -25.468 -7.894  1.000 53.240  0 50  SER A N   1 
ATOM   282  C CA  . SER A 1 46  ? 40.309  -24.197 -7.844  1.000 47.440  0 50  SER A CA  1 
ATOM   283  C C   . SER A 1 46  ? 40.945  -23.127 -8.725  1.000 54.290  0 50  SER A C   1 
ATOM   284  O O   . SER A 1 46  ? 40.265  -22.162 -9.087  1.000 56.700  0 50  SER A O   1 
ATOM   285  C CB  . SER A 1 46  ? 40.216  -23.691 -6.405  1.000 50.930  0 50  SER A CB  1 
ATOM   286  O OG  . SER A 1 46  ? 41.447  -23.120 -5.982  1.000 53.040  0 50  SER A OG  1 
ATOM   287  N N   . ALA A 1 47  ? 42.227  -23.270 -9.076  1.000 51.330  0 51  ALA A N   1 
ATOM   288  C CA  . ALA A 1 47  ? 42.863  -22.290 -9.954  1.000 53.410  0 51  ALA A CA  1 
ATOM   289  C C   . ALA A 1 47  ? 42.548  -22.566 -11.419 1.000 55.730  0 51  ALA A C   1 
ATOM   290  O O   . ALA A 1 47  ? 42.240  -21.641 -12.177 1.000 55.520  0 51  ALA A O   1 
ATOM   291  C CB  . ALA A 1 47  ? 44.376  -22.279 -9.729  1.000 56.010  0 51  ALA A CB  1 
ATOM   292  N N   . LYS A 1 48  ? 42.619  -23.833 -11.831 1.000 52.980  0 52  LYS A N   1 
ATOM   293  C CA  . LYS A 1 48  ? 42.317  -24.187 -13.212 1.000 51.100  0 52  LYS A CA  1 
ATOM   294  C C   . LYS A 1 48  ? 40.826  -24.124 -13.519 1.000 53.730  0 52  LYS A C   1 
ATOM   295  O O   . LYS A 1 48  ? 40.452  -24.009 -14.691 1.000 56.080  0 52  LYS A O   1 
ATOM   296  C CB  . LYS A 1 48  ? 42.857  -25.583 -13.509 1.000 59.570  0 52  LYS A CB  1 
ATOM   297  C CG  . LYS A 1 48  ? 44.356  -25.704 -13.300 1.000 69.100  0 52  LYS A CG  1 
ATOM   298  C CD  . LYS A 1 48  ? 44.771  -27.147 -13.083 1.000 70.430  0 52  LYS A CD  1 
ATOM   299  C CE  . LYS A 1 48  ? 46.088  -27.443 -13.780 1.000 68.280  0 52  LYS A CE  1 
ATOM   300  N NZ  . LYS A 1 48  ? 47.175  -27.700 -12.802 1.000 71.780  0 52  LYS A NZ  1 
ATOM   301  N N   . LYS A 1 49  ? 39.975  -24.198 -12.499 1.000 54.260  0 53  LYS A N   1 
ATOM   302  C CA  . LYS A 1 49  ? 38.523  -24.162 -12.651 1.000 50.890  0 53  LYS A CA  1 
ATOM   303  C C   . LYS A 1 49  ? 38.035  -25.130 -13.731 1.000 50.740  0 53  LYS A C   1 
ATOM   304  O O   . LYS A 1 49  ? 37.536  -24.697 -14.777 1.000 47.950  0 53  LYS A O   1 
ATOM   305  C CB  . LYS A 1 49  ? 38.062  -22.736 -12.953 1.000 56.410  0 53  LYS A CB  1 
ATOM   306  C CG  . LYS A 1 49  ? 38.547  -21.723 -11.921 1.000 64.020  0 53  LYS A CG  1 
ATOM   307  C CD  . LYS A 1 49  ? 37.416  -20.863 -11.384 1.000 65.410  0 53  LYS A CD  1 
ATOM   308  C CE  . LYS A 1 49  ? 37.918  -19.881 -10.330 1.000 65.580  0 53  LYS A CE  1 
ATOM   309  N NZ  . LYS A 1 49  ? 37.789  -20.424 -8.947  1.000 65.070  0 53  LYS A NZ  1 
ATOM   310  N N   . PRO A 1 50  ? 38.140  -26.443 -13.504 1.000 48.430  0 54  PRO A N   1 
ATOM   311  C CA  . PRO A 1 50  ? 37.699  -27.411 -14.524 1.000 51.380  0 54  PRO A CA  1 
ATOM   312  C C   . PRO A 1 50  ? 36.198  -27.423 -14.755 1.000 53.290  0 54  PRO A C   1 
ATOM   313  O O   . PRO A 1 50  ? 35.750  -28.033 -15.738 1.000 50.790  0 54  PRO A O   1 
ATOM   314  C CB  . PRO A 1 50  ? 38.162  -28.754 -13.948 1.000 45.050  0 54  PRO A CB  1 
ATOM   315  C CG  . PRO A 1 50  ? 38.082  -28.546 -12.467 1.000 43.770  0 54  PRO A CG  1 
ATOM   316  C CD  . PRO A 1 50  ? 38.545  -27.110 -12.254 1.000 44.870  0 54  PRO A CD  1 
ATOM   317  N N   . LEU A 1 51  ? 35.413  -26.797 -13.877 1.000 51.710  0 55  LEU A N   1 
ATOM   318  C CA  . LEU A 1 51  ? 33.964  -26.737 -14.005 1.000 47.900  0 55  LEU A CA  1 
ATOM   319  C C   . LEU A 1 51  ? 33.474  -25.349 -14.399 1.000 47.590  0 55  LEU A C   1 
ATOM   320  O O   . LEU A 1 51  ? 32.274  -25.069 -14.294 1.000 50.280  0 55  LEU A O   1 
ATOM   321  C CB  . LEU A 1 51  ? 33.303  -27.190 -12.701 1.000 51.500  0 55  LEU A CB  1 
ATOM   322  C CG  . LEU A 1 51  ? 33.551  -28.647 -12.266 1.000 44.890  0 55  LEU A CG  1 
ATOM   323  C CD1 . LEU A 1 51  ? 32.966  -28.906 -10.876 1.000 42.920  0 55  LEU A CD1 1 
ATOM   324  C CD2 . LEU A 1 51  ? 32.966  -29.628 -13.270 1.000 48.210  0 55  LEU A CD2 1 
ATOM   325  N N   . GLN A 1 52  ? 34.369  -24.472 -14.849 1.000 50.110  0 56  GLN A N   1 
ATOM   326  C CA  . GLN A 1 52  ? 33.924  -23.235 -15.478 1.000 48.380  0 56  GLN A CA  1 
ATOM   327  C C   . GLN A 1 52  ? 33.102  -23.581 -16.708 1.000 49.990  0 56  GLN A C   1 
ATOM   328  O O   . GLN A 1 52  ? 33.546  -24.346 -17.569 1.000 52.590  0 56  GLN A O   1 
ATOM   329  C CB  . GLN A 1 52  ? 35.113  -22.354 -15.866 1.000 50.880  0 56  GLN A CB  1 
ATOM   330  C CG  . GLN A 1 52  ? 34.731  -20.900 -16.131 1.000 64.740  0 56  GLN A CG  1 
ATOM   331  C CD  . GLN A 1 52  ? 34.887  -20.018 -14.900 1.000 79.990  0 56  GLN A CD  1 
ATOM   332  O OE1 . GLN A 1 52  ? 34.086  -20.080 -13.967 1.000 83.020  0 56  GLN A OE1 1 
ATOM   333  N NE2 . GLN A 1 52  ? 35.928  -19.191 -14.895 1.000 88.040  0 56  GLN A NE2 1 
ATOM   334  N N   . GLY A 1 53  ? 31.896  -23.026 -16.782 1.000 52.060  0 57  GLY A N   1 
ATOM   335  C CA  . GLY A 1 53  ? 30.954  -23.383 -17.815 1.000 49.130  0 57  GLY A CA  1 
ATOM   336  C C   . GLY A 1 53  ? 29.984  -24.471 -17.423 1.000 48.570  0 57  GLY A C   1 
ATOM   337  O O   . GLY A 1 53  ? 29.042  -24.739 -18.179 1.000 46.570  0 57  GLY A O   1 
ATOM   338  N N   . ALA A 1 54  ? 30.182  -25.106 -16.273 1.000 48.800  0 58  ALA A N   1 
ATOM   339  C CA  . ALA A 1 54  ? 29.256  -26.124 -15.796 1.000 52.960  0 58  ALA A CA  1 
ATOM   340  C C   . ALA A 1 54  ? 28.060  -25.471 -15.117 1.000 53.470  0 58  ALA A C   1 
ATOM   341  O O   . ALA A 1 54  ? 28.201  -24.486 -14.385 1.000 49.040  0 58  ALA A O   1 
ATOM   342  C CB  . ALA A 1 54  ? 29.954  -27.078 -14.825 1.000 43.800  0 58  ALA A CB  1 
ATOM   343  N N   . ARG A 1 55  ? 26.877  -26.026 -15.368 1.000 47.020  0 59  ARG A N   1 
ATOM   344  C CA  . ARG A 1 55  ? 25.624  -25.510 -14.819 1.000 50.010  0 59  ARG A CA  1 
ATOM   345  C C   . ARG A 1 55  ? 24.886  -26.701 -14.215 1.000 42.140  0 59  ARG A C   1 
ATOM   346  O O   . ARG A 1 55  ? 24.209  -27.450 -14.927 1.000 46.740  0 59  ARG A O   1 
ATOM   347  C CB  . ARG A 1 55  ? 24.805  -24.801 -15.896 1.000 49.800  0 59  ARG A CB  1 
ATOM   348  C CG  . ARG A 1 55  ? 25.502  -23.557 -16.457 1.000 50.020  0 59  ARG A CG  1 
ATOM   349  C CD  . ARG A 1 55  ? 24.614  -22.799 -17.436 1.000 50.800  0 59  ARG A CD  1 
ATOM   350  N NE  . ARG A 1 55  ? 24.197  -23.632 -18.562 1.000 54.340  0 59  ARG A NE  1 
ATOM   351  C CZ  . ARG A 1 55  ? 24.925  -23.848 -19.656 1.000 58.940  0 59  ARG A CZ  1 
ATOM   352  N NH1 . ARG A 1 55  ? 26.127  -23.295 -19.790 1.000 51.530  0 59  ARG A NH1 1 
ATOM   353  N NH2 . ARG A 1 55  ? 24.449  -24.625 -20.620 1.000 57.460  0 59  ARG A NH2 1 
ATOM   354  N N   . ILE A 1 56  ? 25.047  -26.899 -12.911 1.000 45.560  0 60  ILE A N   1 
ATOM   355  C CA  . ILE A 1 56  ? 24.630  -28.132 -12.250 1.000 44.240  0 60  ILE A CA  1 
ATOM   356  C C   . ILE A 1 56  ? 23.302  -27.898 -11.549 1.000 47.140  0 60  ILE A C   1 
ATOM   357  O O   . ILE A 1 56  ? 23.183  -26.994 -10.714 1.000 49.330  0 60  ILE A O   1 
ATOM   358  C CB  . ILE A 1 56  ? 25.690  -28.620 -11.249 1.000 41.230  0 60  ILE A CB  1 
ATOM   359  C CG1 . ILE A 1 56  ? 27.011  -28.892 -11.964 1.000 44.640  0 60  ILE A CG1 1 
ATOM   360  C CG2 . ILE A 1 56  ? 25.209  -29.898 -10.521 1.000 41.940  0 60  ILE A CG2 1 
ATOM   361  C CD1 . ILE A 1 56  ? 28.170  -29.089 -11.019 1.000 44.100  0 60  ILE A CD1 1 
ATOM   362  N N   . ALA A 1 57  ? 22.307  -28.719 -11.876 1.000 47.720  0 61  ALA A N   1 
ATOM   363  C CA  . ALA A 1 57  ? 21.104  -28.840 -11.058 1.000 49.220  0 61  ALA A CA  1 
ATOM   364  C C   . ALA A 1 57  ? 21.334  -29.983 -10.080 1.000 48.430  0 61  ALA A C   1 
ATOM   365  O O   . ALA A 1 57  ? 21.635  -31.109 -10.499 1.000 40.560  0 61  ALA A O   1 
ATOM   366  C CB  . ALA A 1 57  ? 19.862  -29.098 -11.912 1.000 49.480  0 61  ALA A CB  1 
ATOM   367  N N   . GLY A 1 58  ? 21.238  -29.688 -8.792  1.000 41.040  0 62  GLY A N   1 
ATOM   368  C CA  . GLY A 1 58  ? 21.527  -30.661 -7.747  1.000 40.980  0 62  GLY A CA  1 
ATOM   369  C C   . GLY A 1 58  ? 20.293  -30.972 -6.933  1.000 42.310  0 62  GLY A C   1 
ATOM   370  O O   . GLY A 1 58  ? 19.516  -30.074 -6.593  1.000 43.970  0 62  GLY A O   1 
ATOM   371  N N   . CYS A 1 59  ? 20.108  -32.251 -6.613  1.000 42.560  0 63  CYS A N   1 
ATOM   372  C CA  . CYS A 1 59  ? 18.985  -32.690 -5.780  1.000 42.070  0 63  CYS A CA  1 
ATOM   373  C C   . CYS A 1 59  ? 19.553  -33.688 -4.772  1.000 40.180  0 63  CYS A C   1 
ATOM   374  O O   . CYS A 1 59  ? 19.652  -34.891 -5.044  1.000 39.870  0 63  CYS A O   1 
ATOM   375  C CB  . CYS A 1 59  ? 17.861  -33.284 -6.618  1.000 40.650  0 63  CYS A CB  1 
ATOM   376  S SG  . CYS A 1 59  ? 16.422  -33.789 -5.659  1.000 41.070  0 63  CYS A SG  1 
ATOM   377  N N   . LEU A 1 60  ? 19.928  -33.174 -3.605  1.000 38.520  0 64  LEU A N   1 
ATOM   378  C CA  . LEU A 1 60  ? 20.644  -33.961 -2.611  1.000 40.500  0 64  LEU A CA  1 
ATOM   379  C C   . LEU A 1 60  ? 20.507  -33.261 -1.267  1.000 40.690  0 64  LEU A C   1 
ATOM   380  O O   . LEU A 1 60  ? 20.695  -32.040 -1.192  1.000 42.240  0 64  LEU A O   1 
ATOM   381  C CB  . LEU A 1 60  ? 22.128  -34.117 -3.011  1.000 35.570  0 64  LEU A CB  1 
ATOM   382  C CG  . LEU A 1 60  ? 22.971  -35.192 -2.318  1.000 44.350  0 64  LEU A CG  1 
ATOM   383  C CD1 . LEU A 1 60  ? 24.114  -35.675 -3.235  1.000 38.040  0 64  LEU A CD1 1 
ATOM   384  C CD2 . LEU A 1 60  ? 23.532  -34.664 -1.005  1.000 38.530  0 64  LEU A CD2 1 
ATOM   385  N N   . HIS A 1 61  ? 20.179  -34.038 -0.221  1.000 39.550  0 65  HIS A N   1 
ATOM   386  C CA  . HIS A 1 61  ? 19.962  -33.566 1.150   1.000 41.520  0 65  HIS A CA  1 
ATOM   387  C C   . HIS A 1 61  ? 20.764  -32.318 1.491   1.000 37.930  0 65  HIS A C   1 
ATOM   388  O O   . HIS A 1 61  ? 21.998  -32.357 1.481   1.000 39.200  0 65  HIS A O   1 
ATOM   389  C CB  . HIS A 1 61  ? 20.321  -34.661 2.164   1.000 40.330  0 65  HIS A CB  1 
ATOM   390  C CG  . HIS A 1 61  ? 19.762  -36.013 1.836   1.000 36.600  0 65  HIS A CG  1 
ATOM   391  N ND1 . HIS A 1 61  ? 18.443  -36.350 2.056   1.000 38.850  0 65  HIS A ND1 1 
ATOM   392  C CD2 . HIS A 1 61  ? 20.356  -37.127 1.341   1.000 37.370  0 65  HIS A CD2 1 
ATOM   393  C CE1 . HIS A 1 61  ? 18.244  -37.607 1.696   1.000 40.070  0 65  HIS A CE1 1 
ATOM   394  N NE2 . HIS A 1 61  ? 19.390  -38.100 1.253   1.000 36.830  0 65  HIS A NE2 1 
ATOM   395  N N   . MET A 1 62  ? 20.082  -31.207 1.791   1.000 36.330  0 66  MET A N   1 
ATOM   396  C CA  . MET A 1 62  ? 20.755  -29.915 1.990   1.000 36.720  0 66  MET A CA  1 
ATOM   397  C C   . MET A 1 62  ? 21.267  -29.832 3.426   1.000 46.660  0 66  MET A C   1 
ATOM   398  O O   . MET A 1 62  ? 20.717  -29.135 4.283   1.000 42.390  0 66  MET A O   1 
ATOM   399  C CB  . MET A 1 62  ? 19.813  -28.757 1.651   1.000 37.930  0 66  MET A CB  1 
ATOM   400  C CG  . MET A 1 62  ? 20.467  -27.377 1.704   1.000 43.160  0 66  MET A CG  1 
ATOM   401  S SD  . MET A 1 62  ? 21.849  -27.185 0.571   1.000 44.330  0 66  MET A SD  1 
ATOM   402  C CE  . MET A 1 62  ? 23.242  -27.169 1.721   1.000 41.680  0 66  MET A CE  1 
ATOM   403  N N   . THR A 1 63  ? 22.361  -30.557 3.680   1.000 42.030  0 67  THR A N   1 
ATOM   404  C CA  . THR A 1 63  ? 23.024  -30.593 4.975   1.000 37.780  0 67  THR A CA  1 
ATOM   405  C C   . THR A 1 63  ? 24.257  -29.692 4.992   1.000 36.930  0 67  THR A C   1 
ATOM   406  O O   . THR A 1 63  ? 24.693  -29.157 3.971   1.000 40.950  0 67  THR A O   1 
ATOM   407  C CB  . THR A 1 63  ? 23.455  -32.021 5.320   1.000 39.360  0 67  THR A CB  1 
ATOM   408  O OG1 . THR A 1 63  ? 24.411  -32.461 4.348   1.000 40.520  0 67  THR A OG1 1 
ATOM   409  C CG2 . THR A 1 63  ? 22.260  -32.966 5.324   1.000 39.570  0 67  THR A CG2 1 
ATOM   410  N N   . ILE A 1 64  ? 24.829  -29.551 6.190   1.000 39.130  0 68  ILE A N   1 
ATOM   411  C CA  . ILE A 1 64  ? 26.117  -28.881 6.342   1.000 41.200  0 68  ILE A CA  1 
ATOM   412  C C   . ILE A 1 64  ? 27.173  -29.534 5.454   1.000 46.180  0 68  ILE A C   1 
ATOM   413  O O   . ILE A 1 64  ? 28.006  -28.846 4.847   1.000 38.190  0 68  ILE A O   1 
ATOM   414  C CB  . ILE A 1 64  ? 26.541  -28.884 7.826   1.000 39.520  0 68  ILE A CB  1 
ATOM   415  C CG1 . ILE A 1 64  ? 25.667  -27.925 8.653   1.000 38.290  0 68  ILE A CG1 1 
ATOM   416  C CG2 . ILE A 1 64  ? 28.015  -28.534 7.971   1.000 41.500  0 68  ILE A CG2 1 
ATOM   417  C CD1 . ILE A 1 64  ? 25.897  -26.434 8.359   1.000 38.290  0 68  ILE A CD1 1 
ATOM   418  N N   . GLN A 1 65  ? 27.159  -30.870 5.358   1.000 39.790  0 69  GLN A N   1 
ATOM   419  C CA  . GLN A 1 65  ? 28.155  -31.552 4.534   1.000 36.060  0 69  GLN A CA  1 
ATOM   420  C C   . GLN A 1 65  ? 27.918  -31.263 3.057   1.000 40.910  0 69  GLN A C   1 
ATOM   421  O O   . GLN A 1 65  ? 28.868  -31.065 2.289   1.000 38.550  0 69  GLN A O   1 
ATOM   422  C CB  . GLN A 1 65  ? 28.136  -33.061 4.808   1.000 34.770  0 69  GLN A CB  1 
ATOM   423  C CG  . GLN A 1 65  ? 28.617  -33.459 6.218   1.000 33.190  0 69  GLN A CG  1 
ATOM   424  C CD  . GLN A 1 65  ? 27.700  -32.939 7.331   1.000 39.970  0 69  GLN A CD  1 
ATOM   425  O OE1 . GLN A 1 65  ? 26.494  -32.776 7.133   1.000 42.080  0 69  GLN A OE1 1 
ATOM   426  N NE2 . GLN A 1 65  ? 28.276  -32.656 8.491   1.000 41.340  0 69  GLN A NE2 1 
ATOM   427  N N   . THR A 1 66  ? 26.653  -31.209 2.647   1.000 35.690  0 70  THR A N   1 
ATOM   428  C CA  . THR A 1 66  ? 26.338  -30.883 1.262   1.000 36.120  0 70  THR A CA  1 
ATOM   429  C C   . THR A 1 66  ? 26.721  -29.447 0.921   1.000 39.550  0 70  THR A C   1 
ATOM   430  O O   . THR A 1 66  ? 27.083  -29.163 -0.225  1.000 37.440  0 70  THR A O   1 
ATOM   431  C CB  . THR A 1 66  ? 24.853  -31.153 1.021   1.000 36.050  0 70  THR A CB  1 
ATOM   432  O OG1 . THR A 1 66  ? 24.631  -32.556 1.185   1.000 37.250  0 70  THR A OG1 1 
ATOM   433  C CG2 . THR A 1 66  ? 24.416  -30.742 -0.378  1.000 36.700  0 70  THR A CG2 1 
ATOM   434  N N   . ALA A 1 67  ? 26.675  -28.537 1.897   1.000 39.750  0 71  ALA A N   1 
ATOM   435  C CA  . ALA A 1 67  ? 27.137  -27.172 1.638   1.000 42.430  0 71  ALA A CA  1 
ATOM   436  C C   . ALA A 1 67  ? 28.618  -27.156 1.256   1.000 43.120  0 71  ALA A C   1 
ATOM   437  O O   . ALA A 1 67  ? 29.040  -26.366 0.401   1.000 42.590  0 71  ALA A O   1 
ATOM   438  C CB  . ALA A 1 67  ? 26.884  -26.288 2.859   1.000 34.930  0 71  ALA A CB  1 
ATOM   439  N N   . VAL A 1 68  ? 29.421  -28.026 1.877   1.000 40.940  0 72  VAL A N   1 
ATOM   440  C CA  . VAL A 1 68  ? 30.835  -28.123 1.519   1.000 42.300  0 72  VAL A CA  1 
ATOM   441  C C   . VAL A 1 68  ? 30.996  -28.693 0.110   1.000 42.820  0 72  VAL A C   1 
ATOM   442  O O   . VAL A 1 68  ? 31.874  -28.263 -0.648  1.000 39.580  0 72  VAL A O   1 
ATOM   443  C CB  . VAL A 1 68  ? 31.595  -28.962 2.563   1.000 40.970  0 72  VAL A CB  1 
ATOM   444  C CG1 . VAL A 1 68  ? 33.081  -29.009 2.230   1.000 36.710  0 72  VAL A CG1 1 
ATOM   445  C CG2 . VAL A 1 68  ? 31.376  -28.393 3.955   1.000 42.070  0 72  VAL A CG2 1 
ATOM   446  N N   . LEU A 1 69  ? 30.165  -29.678 -0.257  1.000 38.790  0 73  LEU A N   1 
ATOM   447  C CA  . LEU A 1 69  ? 30.086  -30.127 -1.649  1.000 39.300  0 73  LEU A CA  1 
ATOM   448  C C   . LEU A 1 69  ? 29.746  -28.973 -2.594  1.000 40.300  0 73  LEU A C   1 
ATOM   449  O O   . LEU A 1 69  ? 30.409  -28.778 -3.621  1.000 42.390  0 73  LEU A O   1 
ATOM   450  C CB  . LEU A 1 69  ? 29.039  -31.246 -1.794  1.000 33.180  0 73  LEU A CB  1 
ATOM   451  C CG  . LEU A 1 69  ? 28.668  -31.608 -3.244  1.000 41.720  0 73  LEU A CG  1 
ATOM   452  C CD1 . LEU A 1 69  ? 29.893  -32.072 -4.063  1.000 41.400  0 73  LEU A CD1 1 
ATOM   453  C CD2 . LEU A 1 69  ? 27.548  -32.662 -3.319  1.000 36.180  0 73  LEU A CD2 1 
ATOM   454  N N   . ILE A 1 70  ? 28.693  -28.211 -2.282  1.000 38.200  0 74  ILE A N   1 
ATOM   455  C CA  . ILE A 1 70  ? 28.267  -27.135 -3.180  1.000 36.500  0 74  ILE A CA  1 
ATOM   456  C C   . ILE A 1 70  ? 29.393  -26.126 -3.385  1.000 42.470  0 74  ILE A C   1 
ATOM   457  O O   . ILE A 1 70  ? 29.703  -25.732 -4.517  1.000 40.730  0 74  ILE A O   1 
ATOM   458  C CB  . ILE A 1 70  ? 26.990  -26.458 -2.645  1.000 38.640  0 74  ILE A CB  1 
ATOM   459  C CG1 . ILE A 1 70  ? 25.796  -27.427 -2.724  1.000 43.630  0 74  ILE A CG1 1 
ATOM   460  C CG2 . ILE A 1 70  ? 26.697  -25.150 -3.396  1.000 44.090  0 74  ILE A CG2 1 
ATOM   461  C CD1 . ILE A 1 70  ? 24.588  -26.989 -1.865  1.000 38.570  0 74  ILE A CD1 1 
ATOM   462  N N   . GLU A 1 71  ? 30.009  -25.675 -2.291  1.000 41.810  0 75  GLU A N   1 
ATOM   463  C CA  . GLU A 1 71  ? 31.056  -24.668 -2.400  1.000 48.870  0 75  GLU A CA  1 
ATOM   464  C C   . GLU A 1 71  ? 32.324  -25.211 -3.049  1.000 49.890  0 75  GLU A C   1 
ATOM   465  O O   . GLU A 1 71  ? 33.109  -24.430 -3.595  1.000 46.560  0 75  GLU A O   1 
ATOM   466  C CB  . GLU A 1 71  ? 31.364  -24.093 -1.015  1.000 50.810  0 75  GLU A CB  1 
ATOM   467  C CG  . GLU A 1 71  ? 30.169  -23.358 -0.385  1.000 53.240  0 75  GLU A CG  1 
ATOM   468  C CD  . GLU A 1 71  ? 30.557  -22.452 0.777   1.000 54.840  0 75  GLU A CD  1 
ATOM   469  O OE1 . GLU A 1 71  ? 31.082  -22.953 1.793   1.000 49.810  0 75  GLU A OE1 1 
ATOM   470  O OE2 . GLU A 1 71  ? 30.329  -21.231 0.679   1.000 54.480  0 75  GLU A OE2 1 
ATOM   471  N N   . THR A 1 72  ? 32.555  -26.523 -2.988  1.000 39.840  0 76  THR A N   1 
ATOM   472  C CA  . THR A 1 72  ? 33.660  -27.110 -3.743  1.000 42.940  0 76  THR A CA  1 
ATOM   473  C C   . THR A 1 72  ? 33.385  -27.041 -5.239  1.000 45.030  0 76  THR A C   1 
ATOM   474  O O   . THR A 1 72  ? 34.266  -26.677 -6.030  1.000 39.540  0 76  THR A O   1 
ATOM   475  C CB  . THR A 1 72  ? 33.882  -28.561 -3.320  1.000 40.900  0 76  THR A CB  1 
ATOM   476  O OG1 . THR A 1 72  ? 34.193  -28.602 -1.930  1.000 39.690  0 76  THR A OG1 1 
ATOM   477  C CG2 . THR A 1 72  ? 35.032  -29.189 -4.119  1.000 40.370  0 76  THR A CG2 1 
ATOM   478  N N   . LEU A 1 73  ? 32.165  -27.400 -5.646  1.000 41.180  0 77  LEU A N   1 
ATOM   479  C CA  . LEU A 1 73  ? 31.787  -27.273 -7.048  1.000 38.990  0 77  LEU A CA  1 
ATOM   480  C C   . LEU A 1 73  ? 31.922  -25.835 -7.515  1.000 41.180  0 77  LEU A C   1 
ATOM   481  O O   . LEU A 1 73  ? 32.431  -25.574 -8.614  1.000 42.840  0 77  LEU A O   1 
ATOM   482  C CB  . LEU A 1 73  ? 30.350  -27.766 -7.265  1.000 46.280  0 77  LEU A CB  1 
ATOM   483  C CG  . LEU A 1 73  ? 30.036  -29.233 -6.970  1.000 41.410  0 77  LEU A CG  1 
ATOM   484  C CD1 . LEU A 1 73  ? 28.516  -29.486 -6.969  1.000 37.600  0 77  LEU A CD1 1 
ATOM   485  C CD2 . LEU A 1 73  ? 30.750  -30.132 -7.985  1.000 37.650  0 77  LEU A CD2 1 
ATOM   486  N N   . VAL A 1 74  ? 31.482  -24.885 -6.684  1.000 43.520  0 78  VAL A N   1 
ATOM   487  C CA  . VAL A 1 74  ? 31.556  -23.473 -7.052  1.000 47.540  0 78  VAL A CA  1 
ATOM   488  C C   . VAL A 1 74  ? 33.006  -23.019 -7.148  1.000 48.750  0 78  VAL A C   1 
ATOM   489  O O   . VAL A 1 74  ? 33.394  -22.332 -8.104  1.000 42.800  0 78  VAL A O   1 
ATOM   490  C CB  . VAL A 1 74  ? 30.757  -22.619 -6.049  1.000 43.970  0 78  VAL A CB  1 
ATOM   491  C CG1 . VAL A 1 74  ? 31.041  -21.144 -6.275  1.000 46.160  0 78  VAL A CG1 1 
ATOM   492  C CG2 . VAL A 1 74  ? 29.263  -22.909 -6.183  1.000 43.060  0 78  VAL A CG2 1 
ATOM   493  N N   . ALA A 1 75  ? 33.833  -23.401 -6.169  1.000 48.750  0 79  ALA A N   1 
ATOM   494  C CA  . ALA A 1 75  ? 35.250  -23.045 -6.205  1.000 48.230  0 79  ALA A CA  1 
ATOM   495  C C   . ALA A 1 75  ? 35.941  -23.605 -7.440  1.000 46.020  0 79  ALA A C   1 
ATOM   496  O O   . ALA A 1 75  ? 36.956  -23.055 -7.884  1.000 47.250  0 79  ALA A O   1 
ATOM   497  C CB  . ALA A 1 75  ? 35.951  -23.541 -4.940  1.000 46.300  0 79  ALA A CB  1 
ATOM   498  N N   . LEU A 1 76  ? 35.413  -24.687 -8.009  1.000 45.780  0 80  LEU A N   1 
ATOM   499  C CA  . LEU A 1 76  ? 35.950  -25.259 -9.237  1.000 43.240  0 80  LEU A CA  1 
ATOM   500  C C   . LEU A 1 76  ? 35.362  -24.630 -10.495 1.000 47.650  0 80  LEU A C   1 
ATOM   501  O O   . LEU A 1 76  ? 35.664  -25.102 -11.599 1.000 45.980  0 80  LEU A O   1 
ATOM   502  C CB  . LEU A 1 76  ? 35.714  -26.773 -9.260  1.000 42.830  0 80  LEU A CB  1 
ATOM   503  C CG  . LEU A 1 76  ? 36.921  -27.620 -8.841  1.000 47.810  0 80  LEU A CG  1 
ATOM   504  C CD1 . LEU A 1 76  ? 37.475  -27.169 -7.492  1.000 46.240  0 80  LEU A CD1 1 
ATOM   505  C CD2 . LEU A 1 76  ? 36.538  -29.094 -8.796  1.000 46.920  0 80  LEU A CD2 1 
ATOM   506  N N   . GLY A 1 77  ? 34.524  -23.599 -10.360 1.000 49.080  0 81  GLY A N   1 
ATOM   507  C CA  . GLY A 1 77  ? 33.998  -22.864 -11.498 1.000 49.550  0 81  GLY A CA  1 
ATOM   508  C C   . GLY A 1 77  ? 32.544  -23.125 -11.848 1.000 49.530  0 81  GLY A C   1 
ATOM   509  O O   . GLY A 1 77  ? 32.022  -22.466 -12.756 1.000 51.640  0 81  GLY A O   1 
ATOM   510  N N   . ALA A 1 78  ? 31.865  -24.043 -11.169 1.000 45.070  0 82  ALA A N   1 
ATOM   511  C CA  . ALA A 1 78  ? 30.489  -24.368 -11.516 1.000 45.220  0 82  ALA A CA  1 
ATOM   512  C C   . ALA A 1 78  ? 29.514  -23.299 -11.022 1.000 48.370  0 82  ALA A C   1 
ATOM   513  O O   . ALA A 1 78  ? 29.738  -22.639 -10.003 1.000 46.200  0 82  ALA A O   1 
ATOM   514  C CB  . ALA A 1 78  ? 30.091  -25.729 -10.932 1.000 41.230  0 82  ALA A CB  1 
ATOM   515  N N   . GLU A 1 79  ? 28.430  -23.128 -11.775 1.000 46.980  0 83  GLU A N   1 
ATOM   516  C CA  . GLU A 1 79  ? 27.209  -22.504 -11.284 1.000 50.730  0 83  GLU A CA  1 
ATOM   517  C C   . GLU A 1 79  ? 26.215  -23.617 -10.975 1.000 47.880  0 83  GLU A C   1 
ATOM   518  O O   . GLU A 1 79  ? 26.089  -24.568 -11.756 1.000 50.250  0 83  GLU A O   1 
ATOM   519  C CB  . GLU A 1 79  ? 26.629  -21.532 -12.314 1.000 53.540  0 83  GLU A CB  1 
ATOM   520  C CG  . GLU A 1 79  ? 27.445  -20.254 -12.507 1.000 53.240  0 83  GLU A CG  1 
ATOM   521  C CD  . GLU A 1 79  ? 27.019  -19.467 -13.742 1.000 60.750  0 83  GLU A CD  1 
ATOM   522  O OE1 . GLU A 1 79  ? 26.030  -19.860 -14.399 1.000 59.410  0 83  GLU A OE1 1 
ATOM   523  O OE2 . GLU A 1 79  ? 27.681  -18.458 -14.064 1.000 63.620  0 83  GLU A OE2 1 
ATOM   524  N N   . VAL A 1 80  ? 25.545  -23.530 -9.820  1.000 44.480  0 84  VAL A N   1 
ATOM   525  C CA  . VAL A 1 80  ? 24.615  -24.574 -9.404  1.000 45.140  0 84  VAL A CA  1 
ATOM   526  C C   . VAL A 1 80  ? 23.290  -23.963 -8.959  1.000 48.730  0 84  VAL A C   1 
ATOM   527  O O   . VAL A 1 80  ? 23.190  -22.778 -8.632  1.000 45.340  0 84  VAL A O   1 
ATOM   528  C CB  . VAL A 1 80  ? 25.183  -25.483 -8.278  1.000 46.160  0 84  VAL A CB  1 
ATOM   529  C CG1 . VAL A 1 80  ? 26.647  -25.857 -8.543  1.000 50.400  0 84  VAL A CG1 1 
ATOM   530  C CG2 . VAL A 1 80  ? 25.027  -24.830 -6.911  1.000 48.970  0 84  VAL A CG2 1 
ATOM   531  N N   . ARG A 1 81  ? 22.254  -24.799 -8.983  1.000 44.370  0 85  ARG A N   1 
ATOM   532  C CA  . ARG A 1 81  ? 20.972  -24.516 -8.348  1.000 43.720  0 85  ARG A CA  1 
ATOM   533  C C   . ARG A 1 81  ? 20.584  -25.768 -7.585  1.000 46.560  0 85  ARG A C   1 
ATOM   534  O O   . ARG A 1 81  ? 20.651  -26.872 -8.139  1.000 47.010  0 85  ARG A O   1 
ATOM   535  C CB  . ARG A 1 81  ? 19.888  -24.155 -9.365  1.000 48.660  0 85  ARG A CB  1 
ATOM   536  C CG  . ARG A 1 81  ? 20.174  -22.906 -10.179 1.000 49.840  0 85  ARG A CG  1 
ATOM   537  C CD  . ARG A 1 81  ? 19.061  -22.662 -11.181 1.000 50.550  0 85  ARG A CD  1 
ATOM   538  N NE  . ARG A 1 81  ? 17.827  -22.171 -10.566 1.000 49.310  0 85  ARG A NE  1 
ATOM   539  C CZ  . ARG A 1 81  ? 17.621  -20.907 -10.203 1.000 58.320  0 85  ARG A CZ  1 
ATOM   540  N NH1 . ARG A 1 81  ? 18.571  -19.990 -10.378 1.000 54.250  0 85  ARG A NH1 1 
ATOM   541  N NH2 . ARG A 1 81  ? 16.462  -20.556 -9.664  1.000 56.680  0 85  ARG A NH2 1 
ATOM   542  N N   . TRP A 1 82  ? 20.221  -25.617 -6.314  1.000 41.390  0 86  TRP A N   1 
ATOM   543  C CA  . TRP A 1 82  ? 20.144  -26.768 -5.426  1.000 46.250  0 86  TRP A CA  1 
ATOM   544  C C   . TRP A 1 82  ? 18.766  -26.927 -4.802  1.000 43.380  0 86  TRP A C   1 
ATOM   545  O O   . TRP A 1 82  ? 18.099  -25.943 -4.474  1.000 42.920  0 86  TRP A O   1 
ATOM   546  C CB  . TRP A 1 82  ? 21.190  -26.685 -4.308  1.000 43.080  0 86  TRP A CB  1 
ATOM   547  C CG  . TRP A 1 82  ? 21.724  -28.034 -3.948  1.000 46.320  0 86  TRP A CG  1 
ATOM   548  C CD1 . TRP A 1 82  ? 21.262  -28.872 -2.966  1.000 39.670  0 86  TRP A CD1 1 
ATOM   549  C CD2 . TRP A 1 82  ? 22.808  -28.716 -4.583  1.000 44.940  0 86  TRP A CD2 1 
ATOM   550  N NE1 . TRP A 1 82  ? 22.007  -30.027 -2.948  1.000 39.020  0 86  TRP A NE1 1 
ATOM   551  C CE2 . TRP A 1 82  ? 22.964  -29.954 -3.929  1.000 44.560  0 86  TRP A CE2 1 
ATOM   552  C CE3 . TRP A 1 82  ? 23.675  -28.393 -5.637  1.000 44.990  0 86  TRP A CE3 1 
ATOM   553  C CZ2 . TRP A 1 82  ? 23.952  -30.880 -4.300  1.000 43.160  0 86  TRP A CZ2 1 
ATOM   554  C CZ3 . TRP A 1 82  ? 24.657  -29.308 -5.999  1.000 46.120  0 86  TRP A CZ3 1 
ATOM   555  C CH2 . TRP A 1 82  ? 24.784  -30.537 -5.334  1.000 46.150  0 86  TRP A CH2 1 
ATOM   556  N N   . SER A 1 83  ? 18.369  -28.188 -4.635  1.000 44.520  0 87  SER A N   1 
ATOM   557  C CA  . SER A 1 83  ? 17.200  -28.586 -3.866  1.000 45.020  0 87  SER A CA  1 
ATOM   558  C C   . SER A 1 83  ? 17.572  -29.812 -3.043  1.000 43.470  0 87  SER A C   1 
ATOM   559  O O   . SER A 1 83  ? 18.549  -30.498 -3.337  1.000 41.550  0 87  SER A O   1 
ATOM   560  C CB  . SER A 1 83  ? 16.018  -28.916 -4.775  1.000 47.030  0 87  SER A CB  1 
ATOM   561  O OG  . SER A 1 83  ? 16.300  -30.100 -5.501  1.000 41.890  0 87  SER A OG  1 
ATOM   562  N N   . SER A 1 84  ? 16.792  -30.090 -2.006  1.000 40.560  0 88  SER A N   1 
ATOM   563  C CA  . SER A 1 84  ? 17.013  -31.306 -1.239  1.000 42.570  0 88  SER A CA  1 
ATOM   564  C C   . SER A 1 84  ? 16.210  -32.450 -1.846  1.000 38.370  0 88  SER A C   1 
ATOM   565  O O   . SER A 1 84  ? 15.199  -32.226 -2.525  1.000 43.810  0 88  SER A O   1 
ATOM   566  C CB  . SER A 1 84  ? 16.630  -31.102 0.227   1.000 40.470  0 88  SER A CB  1 
ATOM   567  O OG  . SER A 1 84  ? 16.887  -32.261 0.995   1.000 44.500  0 88  SER A OG  1 
ATOM   568  N N   . CYS A 1 85  ? 16.678  -33.684 -1.609  1.000 40.670  0 89  CYS A N   1 
ATOM   569  C CA  . CYS A 1 85  ? 15.996  -34.886 -2.083  1.000 38.230  0 89  CYS A CA  1 
ATOM   570  C C   . CYS A 1 85  ? 15.123  -35.532 -1.010  1.000 42.690  0 89  CYS A C   1 
ATOM   571  O O   . CYS A 1 85  ? 14.672  -36.666 -1.194  1.000 42.690  0 89  CYS A O   1 
ATOM   572  C CB  . CYS A 1 85  ? 17.007  -35.900 -2.633  1.000 38.090  0 89  CYS A CB  1 
ATOM   573  S SG  . CYS A 1 85  ? 18.203  -36.584 -1.421  1.000 40.430  0 89  CYS A SG  1 
ATOM   574  N N   . ASN A 1 86  ? 14.852  -34.831 0.089   1.000 41.280  0 90  ASN A N   1 
ATOM   575  C CA  . ASN A 1 86  ? 13.917  -35.317 1.096   1.000 41.020  0 90  ASN A CA  1 
ATOM   576  C C   . ASN A 1 86  ? 13.301  -34.121 1.811   1.000 46.850  0 90  ASN A C   1 
ATOM   577  O O   . ASN A 1 86  ? 13.971  -33.105 2.038   1.000 42.110  0 90  ASN A O   1 
ATOM   578  C CB  . ASN A 1 86  ? 14.598  -36.250 2.107   1.000 36.740  0 90  ASN A CB  1 
ATOM   579  C CG  . ASN A 1 86  ? 13.599  -36.924 3.041   1.000 42.620  0 90  ASN A CG  1 
ATOM   580  O OD1 . ASN A 1 86  ? 13.195  -36.351 4.053   1.000 42.340  0 90  ASN A OD1 1 
ATOM   581  N ND2 . ASN A 1 86  ? 13.187  -38.143 2.696   1.000 42.680  0 90  ASN A ND2 1 
ATOM   582  N N   . ILE A 1 87  ? 12.021  -34.266 2.180   1.000 42.940  0 91  ILE A N   1 
ATOM   583  C CA  . ILE A 1 87  ? 11.266  -33.178 2.795   1.000 42.000  0 91  ILE A CA  1 
ATOM   584  C C   . ILE A 1 87  ? 11.734  -32.858 4.208   1.000 36.950  0 91  ILE A C   1 
ATOM   585  O O   . ILE A 1 87  ? 11.440  -31.769 4.706   1.000 43.820  0 91  ILE A O   1 
ATOM   586  C CB  . ILE A 1 87  ? 9.748   -33.474 2.833   1.000 40.280  0 91  ILE A CB  1 
ATOM   587  C CG1 . ILE A 1 87  ? 9.437   -34.688 3.712   1.000 44.720  0 91  ILE A CG1 1 
ATOM   588  C CG2 . ILE A 1 87  ? 9.163   -33.618 1.417   1.000 40.180  0 91  ILE A CG2 1 
ATOM   589  C CD1 . ILE A 1 87  ? 7.937   -34.962 3.862   1.000 40.900  0 91  ILE A CD1 1 
ATOM   590  N N   . PHE A 1 88  ? 12.445  -33.772 4.879   1.000 38.860  0 92  PHE A N   1 
ATOM   591  C CA  . PHE A 1 88  ? 12.884  -33.537 6.251   1.000 44.920  0 92  PHE A CA  1 
ATOM   592  C C   . PHE A 1 88  ? 14.395  -33.412 6.407   1.000 42.470  0 92  PHE A C   1 
ATOM   593  O O   . PHE A 1 88  ? 14.858  -33.131 7.516   1.000 42.050  0 92  PHE A O   1 
ATOM   594  C CB  . PHE A 1 88  ? 12.403  -34.668 7.178   1.000 43.790  0 92  PHE A CB  1 
ATOM   595  C CG  . PHE A 1 88  ? 10.907  -34.702 7.389   1.000 42.700  0 92  PHE A CG  1 
ATOM   596  C CD1 . PHE A 1 88  ? 10.216  -33.565 7.778   1.000 46.630  0 92  PHE A CD1 1 
ATOM   597  C CD2 . PHE A 1 88  ? 10.201  -35.885 7.219   1.000 42.230  0 92  PHE A CD2 1 
ATOM   598  C CE1 . PHE A 1 88  ? 8.839   -33.609 7.980   1.000 52.690  0 92  PHE A CE1 1 
ATOM   599  C CE2 . PHE A 1 88  ? 8.829   -35.939 7.417   1.000 46.740  0 92  PHE A CE2 1 
ATOM   600  C CZ  . PHE A 1 88  ? 8.147   -34.800 7.796   1.000 49.880  0 92  PHE A CZ  1 
ATOM   601  N N   . SER A 1 89  ? 15.172  -33.629 5.354   1.000 41.860  0 93  SER A N   1 
ATOM   602  C CA  . SER A 1 89  ? 16.611  -33.785 5.520   1.000 38.580  0 93  SER A CA  1 
ATOM   603  C C   . SER A 1 89  ? 17.378  -32.471 5.488   1.000 40.630  0 93  SER A C   1 
ATOM   604  O O   . SER A 1 89  ? 18.554  -32.455 5.873   1.000 41.570  0 93  SER A O   1 
ATOM   605  C CB  . SER A 1 89  ? 17.172  -34.722 4.450   1.000 38.780  0 93  SER A CB  1 
ATOM   606  O OG  . SER A 1 89  ? 17.023  -34.163 3.160   1.000 38.290  0 93  SER A OG  1 
ATOM   607  N N   . THR A 1 90  ? 16.764  -31.379 5.037   1.000 40.270  0 94  THR A N   1 
ATOM   608  C CA  . THR A 1 90  ? 17.471  -30.103 5.021   1.000 43.450  0 94  THR A CA  1 
ATOM   609  C C   . THR A 1 90  ? 17.850  -29.683 6.439   1.000 42.890  0 94  THR A C   1 
ATOM   610  O O   . THR A 1 90  ? 17.077  -29.847 7.387   1.000 42.570  0 94  THR A O   1 
ATOM   611  C CB  . THR A 1 90  ? 16.610  -29.008 4.374   1.000 44.930  0 94  THR A CB  1 
ATOM   612  O OG1 . THR A 1 90  ? 16.389  -29.317 2.991   1.000 42.510  0 94  THR A OG1 1 
ATOM   613  C CG2 . THR A 1 90  ? 17.297  -27.638 4.477   1.000 40.470  0 94  THR A CG2 1 
ATOM   614  N N   . GLN A 1 91  ? 19.057  -29.157 6.586   1.000 38.820  0 95  GLN A N   1 
ATOM   615  C CA  . GLN A 1 91  ? 19.431  -28.409 7.776   1.000 38.390  0 95  GLN A CA  1 
ATOM   616  C C   . GLN A 1 91  ? 19.286  -26.937 7.431   1.000 42.150  0 95  GLN A C   1 
ATOM   617  O O   . GLN A 1 91  ? 20.077  -26.398 6.652   1.000 44.790  0 95  GLN A O   1 
ATOM   618  C CB  . GLN A 1 91  ? 20.850  -28.733 8.214   1.000 37.440  0 95  GLN A CB  1 
ATOM   619  C CG  . GLN A 1 91  ? 21.014  -30.115 8.765   1.000 46.940  0 95  GLN A CG  1 
ATOM   620  C CD  . GLN A 1 91  ? 22.416  -30.303 9.244   1.000 49.380  0 95  GLN A CD  1 
ATOM   621  O OE1 . GLN A 1 91  ? 23.308  -30.519 8.443   1.000 43.610  0 95  GLN A OE1 1 
ATOM   622  N NE2 . GLN A 1 91  ? 22.633  -30.174 10.553  1.000 54.600  0 95  GLN A NE2 1 
ATOM   623  N N   . ASP A 1 92  ? 18.272  -26.300 8.014   1.000 45.150  0 96  ASP A N   1 
ATOM   624  C CA  . ASP A 1 92  ? 17.926  -24.935 7.642   1.000 40.990  0 96  ASP A CA  1 
ATOM   625  C C   . ASP A 1 92  ? 19.133  -24.005 7.690   1.000 46.640  0 96  ASP A C   1 
ATOM   626  O O   . ASP A 1 92  ? 19.294  -23.147 6.813   1.000 49.530  0 96  ASP A O   1 
ATOM   627  C CB  . ASP A 1 92  ? 16.815  -24.424 8.554   1.000 40.590  0 96  ASP A CB  1 
ATOM   628  C CG  . ASP A 1 92  ? 15.462  -25.017 8.206   1.000 46.810  0 96  ASP A CG  1 
ATOM   629  O OD1 . ASP A 1 92  ? 15.318  -25.598 7.107   1.000 45.880  0 96  ASP A OD1 1 
ATOM   630  O OD2 . ASP A 1 92  ? 14.540  -24.897 9.034   1.000 50.880  0 96  ASP A OD2 1 
ATOM   631  N N   . HIS A 1 93  ? 20.005  -24.163 8.693   1.000 48.480  0 97  HIS A N   1 
ATOM   632  C CA  . HIS A 1 93  ? 21.131  -23.240 8.786   1.000 49.460  0 97  HIS A CA  1 
ATOM   633  C C   . HIS A 1 93  ? 22.177  -23.517 7.711   1.000 53.760  0 97  HIS A C   1 
ATOM   634  O O   . HIS A 1 93  ? 22.880  -22.593 7.290   1.000 46.080  0 97  HIS A O   1 
ATOM   635  C CB  . HIS A 1 93  ? 21.747  -23.254 10.197  1.000 42.500  0 97  HIS A CB  1 
ATOM   636  C CG  . HIS A 1 93  ? 22.285  -24.582 10.638  1.000 50.370  0 97  HIS A CG  1 
ATOM   637  N ND1 . HIS A 1 93  ? 21.496  -25.706 10.756  1.000 50.030  0 97  HIS A ND1 1 
ATOM   638  C CD2 . HIS A 1 93  ? 23.525  -24.950 11.043  1.000 51.680  0 97  HIS A CD2 1 
ATOM   639  C CE1 . HIS A 1 93  ? 22.235  -26.717 11.183  1.000 55.900  0 97  HIS A CE1 1 
ATOM   640  N NE2 . HIS A 1 93  ? 23.469  -26.284 11.367  1.000 50.300  0 97  HIS A NE2 1 
ATOM   641  N N   . ALA A 1 94  ? 22.277  -24.763 7.230   1.000 45.100  0 98  ALA A N   1 
ATOM   642  C CA  . ALA A 1 94  ? 23.136  -25.037 6.081   1.000 42.180  0 98  ALA A CA  1 
ATOM   643  C C   . ALA A 1 94  ? 22.591  -24.380 4.818   1.000 50.110  0 98  ALA A C   1 
ATOM   644  O O   . ALA A 1 94  ? 23.336  -23.728 4.075   1.000 46.530  0 98  ALA A O   1 
ATOM   645  C CB  . ALA A 1 94  ? 23.280  -26.540 5.872   1.000 38.970  0 98  ALA A CB  1 
ATOM   646  N N   . ALA A 1 95  ? 21.290  -24.547 4.559   1.000 41.500  0 99  ALA A N   1 
ATOM   647  C CA  . ALA A 1 95  ? 20.672  -23.912 3.401   1.000 43.920  0 99  ALA A CA  1 
ATOM   648  C C   . ALA A 1 95  ? 20.833  -22.400 3.451   1.000 50.440  0 99  ALA A C   1 
ATOM   649  O O   . ALA A 1 95  ? 21.075  -21.758 2.420   1.000 47.560  0 99  ALA A O   1 
ATOM   650  C CB  . ALA A 1 95  ? 19.192  -24.286 3.326   1.000 43.280  0 99  ALA A CB  1 
ATOM   651  N N   . SER A 1 96  ? 20.702  -21.815 4.645   1.000 47.110  0 100 SER A N   1 
ATOM   652  C CA  . SER A 1 96  ? 20.829  -20.367 4.783   1.000 50.120  0 100 SER A CA  1 
ATOM   653  C C   . SER A 1 96  ? 22.244  -19.892 4.470   1.000 51.990  0 100 SER A C   1 
ATOM   654  O O   . SER A 1 96  ? 22.425  -18.869 3.799   1.000 54.790  0 100 SER A O   1 
ATOM   655  C CB  . SER A 1 96  ? 20.422  -19.944 6.190   1.000 46.000  0 100 SER A CB  1 
ATOM   656  O OG  . SER A 1 96  ? 19.015  -19.997 6.330   1.000 45.730  0 100 SER A OG  1 
ATOM   657  N N   . ALA A 1 97  ? 23.257  -20.604 4.963   1.000 47.630  0 101 ALA A N   1 
ATOM   658  C CA  . ALA A 1 97  ? 24.637  -20.234 4.659   1.000 48.610  0 101 ALA A CA  1 
ATOM   659  C C   . ALA A 1 97  ? 24.888  -20.252 3.153   1.000 52.290  0 101 ALA A C   1 
ATOM   660  O O   . ALA A 1 97  ? 25.533  -19.347 2.607   1.000 50.400  0 101 ALA A O   1 
ATOM   661  C CB  . ALA A 1 97  ? 25.596  -21.177 5.384   1.000 48.300  0 101 ALA A CB  1 
ATOM   662  N N   . ILE A 1 98  ? 24.356  -21.264 2.465   1.000 48.020  0 102 ILE A N   1 
ATOM   663  C CA  . ILE A 1 98  ? 24.469  -21.340 1.010   1.000 45.800  0 102 ILE A CA  1 
ATOM   664  C C   . ILE A 1 98  ? 23.714  -20.184 0.358   1.000 52.130  0 102 ILE A C   1 
ATOM   665  O O   . ILE A 1 98  ? 24.229  -19.513 -0.544  1.000 51.040  0 102 ILE A O   1 
ATOM   666  C CB  . ILE A 1 98  ? 23.961  -22.708 0.513   1.000 45.710  0 102 ILE A CB  1 
ATOM   667  C CG1 . ILE A 1 98  ? 24.949  -23.822 0.900   1.000 43.030  0 102 ILE A CG1 1 
ATOM   668  C CG2 . ILE A 1 98  ? 23.673  -22.683 -0.995  1.000 41.720  0 102 ILE A CG2 1 
ATOM   669  C CD1 . ILE A 1 98  ? 26.332  -23.665 0.281   1.000 40.180  0 102 ILE A CD1 1 
ATOM   670  N N   . ALA A 1 99  ? 22.483  -19.927 0.816   1.000 46.950  0 103 ALA A N   1 
ATOM   671  C CA  . ALA A 1 99  ? 21.696  -18.829 0.249   1.000 48.260  0 103 ALA A CA  1 
ATOM   672  C C   . ALA A 1 99  ? 22.391  -17.485 0.435   1.000 51.830  0 103 ALA A C   1 
ATOM   673  O O   . ALA A 1 99  ? 22.321  -16.614 -0.443  1.000 47.960  0 103 ALA A O   1 
ATOM   674  C CB  . ALA A 1 99  ? 20.310  -18.790 0.882   1.000 50.020  0 103 ALA A CB  1 
ATOM   675  N N   . ALA A 1 100 ? 23.067  -17.297 1.574   1.000 47.980  0 104 ALA A N   1 
ATOM   676  C CA  . ALA A 1 100 ? 23.734  -16.028 1.859   1.000 56.240  0 104 ALA A CA  1 
ATOM   677  C C   . ALA A 1 100 ? 24.900  -15.769 0.911   1.000 52.960  0 104 ALA A C   1 
ATOM   678  O O   . ALA A 1 100 ? 25.254  -14.608 0.669   1.000 54.820  0 104 ALA A O   1 
ATOM   679  C CB  . ALA A 1 100 ? 24.214  -16.003 3.312   1.000 53.650  0 104 ALA A CB  1 
ATOM   680  N N   . LYS A 1 101 ? 25.516  -16.822 0.379   1.000 52.580  0 105 LYS A N   1 
ATOM   681  C CA  . LYS A 1 101 ? 26.590  -16.705 -0.603  1.000 51.110  0 105 LYS A CA  1 
ATOM   682  C C   . LYS A 1 101 ? 26.084  -16.346 -1.993  1.000 57.480  0 105 LYS A C   1 
ATOM   683  O O   . LYS A 1 101 ? 26.900  -16.162 -2.904  1.000 61.050  0 105 LYS A O   1 
ATOM   684  C CB  . LYS A 1 101 ? 27.383  -18.017 -0.683  1.000 48.760  0 105 LYS A CB  1 
ATOM   685  C CG  . LYS A 1 101 ? 28.204  -18.334 0.563   1.000 56.250  0 105 LYS A CG  1 
ATOM   686  C CD  . LYS A 1 101 ? 29.311  -17.304 0.789   1.000 69.830  0 105 LYS A CD  1 
ATOM   687  C CE  . LYS A 1 101 ? 30.700  -17.924 0.692   1.000 76.120  0 105 LYS A CE  1 
ATOM   688  N NZ  . LYS A 1 101 ? 31.737  -17.107 1.395   1.000 75.260  0 105 LYS A NZ  1 
ATOM   689  N N   . GLY A 1 102 ? 24.771  -16.241 -2.178  1.000 58.280  0 106 GLY A N   1 
ATOM   690  C CA  . GLY A 1 102 ? 24.201  -15.970 -3.479  1.000 60.190  0 106 GLY A CA  1 
ATOM   691  C C   . GLY A 1 102 ? 23.970  -17.198 -4.324  1.000 57.320  0 106 GLY A C   1 
ATOM   692  O O   . GLY A 1 102 ? 23.591  -17.064 -5.493  1.000 58.440  0 106 GLY A O   1 
ATOM   693  N N   . ILE A 1 103 ? 24.190  -18.385 -3.777  1.000 49.690  0 107 ILE A N   1 
ATOM   694  C CA  . ILE A 1 103 ? 23.964  -19.622 -4.525  1.000 53.470  0 107 ILE A CA  1 
ATOM   695  C C   . ILE A 1 103 ? 22.473  -19.959 -4.464  1.000 52.200  0 107 ILE A C   1 
ATOM   696  O O   . ILE A 1 103 ? 21.916  -20.033 -3.358  1.000 51.780  0 107 ILE A O   1 
ATOM   697  C CB  . ILE A 1 103 ? 24.803  -20.757 -3.952  1.000 51.750  0 107 ILE A CB  1 
ATOM   698  C CG1 . ILE A 1 103 ? 26.287  -20.395 -3.973  1.000 52.120  0 107 ILE A CG1 1 
ATOM   699  C CG2 . ILE A 1 103 ? 24.555  -22.059 -4.716  1.000 46.910  0 107 ILE A CG2 1 
ATOM   700  C CD1 . ILE A 1 103 ? 27.125  -21.267 -3.048  1.000 49.740  0 107 ILE A CD1 1 
ATOM   701  N N   . PRO A 1 104 ? 21.807  -20.152 -5.602  1.000 51.970  0 108 PRO A N   1 
ATOM   702  C CA  . PRO A 1 104 ? 20.367  -20.456 -5.571  1.000 47.340  0 108 PRO A CA  1 
ATOM   703  C C   . PRO A 1 104 ? 20.131  -21.815 -4.931  1.000 52.360  0 108 PRO A C   1 
ATOM   704  O O   . PRO A 1 104 ? 20.666  -22.830 -5.385  1.000 50.710  0 108 PRO A O   1 
ATOM   705  C CB  . PRO A 1 104 ? 19.966  -20.450 -7.052  1.000 50.120  0 108 PRO A CB  1 
ATOM   706  C CG  . PRO A 1 104 ? 21.041  -19.644 -7.737  1.000 51.030  0 108 PRO A CG  1 
ATOM   707  C CD  . PRO A 1 104 ? 22.299  -20.017 -6.983  1.000 51.230  0 108 PRO A CD  1 
ATOM   708  N N   . VAL A 1 105 ? 19.337  -21.825 -3.865  1.000 49.770  0 109 VAL A N   1 
ATOM   709  C CA  . VAL A 1 105 ? 18.995  -23.044 -3.139  1.000 53.680  0 109 VAL A CA  1 
ATOM   710  C C   . VAL A 1 105 ? 17.535  -22.941 -2.720  1.000 55.030  0 109 VAL A C   1 
ATOM   711  O O   . VAL A 1 105 ? 17.072  -21.872 -2.309  1.000 46.980  0 109 VAL A O   1 
ATOM   712  C CB  . VAL A 1 105 ? 19.925  -23.269 -1.922  1.000 45.380  0 109 VAL A CB  1 
ATOM   713  C CG1 . VAL A 1 105 ? 19.929  -22.053 -0.991  1.000 47.160  0 109 VAL A CG1 1 
ATOM   714  C CG2 . VAL A 1 105 ? 19.543  -24.539 -1.159  1.000 42.440  0 109 VAL A CG2 1 
ATOM   715  N N   . PHE A 1 106 ? 16.808  -24.056 -2.838  1.000 46.310  0 110 PHE A N   1 
ATOM   716  C CA  . PHE A 1 106 ? 15.373  -24.117 -2.575  1.000 44.300  0 110 PHE A CA  1 
ATOM   717  C C   . PHE A 1 106 ? 15.147  -25.338 -1.685  1.000 49.010  0 110 PHE A C   1 
ATOM   718  O O   . PHE A 1 106 ? 14.948  -26.454 -2.176  1.000 49.000  0 110 PHE A O   1 
ATOM   719  C CB  . PHE A 1 106 ? 14.605  -24.176 -3.893  1.000 49.710  0 110 PHE A CB  1 
ATOM   720  C CG  . PHE A 1 106 ? 14.967  -23.059 -4.846  1.000 48.090  0 110 PHE A CG  1 
ATOM   721  C CD1 . PHE A 1 106 ? 16.048  -23.185 -5.710  1.000 55.190  0 110 PHE A CD1 1 
ATOM   722  C CD2 . PHE A 1 106 ? 14.245  -21.877 -4.855  1.000 53.860  0 110 PHE A CD2 1 
ATOM   723  C CE1 . PHE A 1 106 ? 16.399  -22.155 -6.574  1.000 57.150  0 110 PHE A CE1 1 
ATOM   724  C CE2 . PHE A 1 106 ? 14.584  -20.832 -5.722  1.000 58.360  0 110 PHE A CE2 1 
ATOM   725  C CZ  . PHE A 1 106 ? 15.660  -20.975 -6.584  1.000 60.650  0 110 PHE A CZ  1 
ATOM   726  N N   . ALA A 1 107 ? 15.201  -25.123 -0.369  1.000 40.190  0 111 ALA A N   1 
ATOM   727  C CA  . ALA A 1 107 ? 15.220  -26.228 0.586   1.000 41.960  0 111 ALA A CA  1 
ATOM   728  C C   . ALA A 1 107 ? 14.939  -25.751 2.005   1.000 45.250  0 111 ALA A C   1 
ATOM   729  O O   . ALA A 1 107 ? 15.517  -24.758 2.461   1.000 52.950  0 111 ALA A O   1 
ATOM   730  C CB  . ALA A 1 107 ? 16.570  -26.947 0.555   1.000 41.050  0 111 ALA A CB  1 
ATOM   731  N N   . TRP A 1 108 ? 14.054  -26.454 2.707   1.000 43.630  0 112 TRP A N   1 
ATOM   732  C CA  . TRP A 1 108 ? 13.859  -26.237 4.131   1.000 41.570  0 112 TRP A CA  1 
ATOM   733  C C   . TRP A 1 108 ? 13.368  -27.534 4.758   1.000 46.070  0 112 TRP A C   1 
ATOM   734  O O   . TRP A 1 108 ? 12.849  -28.421 4.075   1.000 42.140  0 112 TRP A O   1 
ATOM   735  C CB  . TRP A 1 108 ? 12.886  -25.079 4.404   1.000 44.190  0 112 TRP A CB  1 
ATOM   736  C CG  . TRP A 1 108 ? 11.576  -25.183 3.709   1.000 45.700  0 112 TRP A CG  1 
ATOM   737  C CD1 . TRP A 1 108 ? 10.415  -25.685 4.221   1.000 49.050  0 112 TRP A CD1 1 
ATOM   738  C CD2 . TRP A 1 108 ? 11.278  -24.758 2.373   1.000 51.040  0 112 TRP A CD2 1 
ATOM   739  N NE1 . TRP A 1 108 ? 9.410   -25.605 3.281   1.000 50.890  0 112 TRP A NE1 1 
ATOM   740  C CE2 . TRP A 1 108 ? 9.914   -25.035 2.140   1.000 55.500  0 112 TRP A CE2 1 
ATOM   741  C CE3 . TRP A 1 108 ? 12.032  -24.172 1.350   1.000 53.290  0 112 TRP A CE3 1 
ATOM   742  C CZ2 . TRP A 1 108 ? 9.288   -24.744 0.925   1.000 46.530  0 112 TRP A CZ2 1 
ATOM   743  C CZ3 . TRP A 1 108 ? 11.409  -23.887 0.143   1.000 47.660  0 112 TRP A CZ3 1 
ATOM   744  C CH2 . TRP A 1 108 ? 10.051  -24.174 -0.058  1.000 50.470  0 112 TRP A CH2 1 
ATOM   745  N N   . LYS A 1 109 ? 13.577  -27.657 6.065   1.000 47.710  0 113 LYS A N   1 
ATOM   746  C CA  . LYS A 1 109 ? 13.159  -28.855 6.777   1.000 43.340  0 113 LYS A CA  1 
ATOM   747  C C   . LYS A 1 109 ? 11.654  -28.824 6.970   1.000 47.050  0 113 LYS A C   1 
ATOM   748  O O   . LYS A 1 109 ? 11.104  -27.824 7.442   1.000 46.870  0 113 LYS A O   1 
ATOM   749  C CB  . LYS A 1 109 ? 13.854  -28.959 8.134   1.000 43.390  0 113 LYS A CB  1 
ATOM   750  C CG  . LYS A 1 109 ? 13.692  -30.323 8.807   1.000 47.680  0 113 LYS A CG  1 
ATOM   751  C CD  . LYS A 1 109 ? 14.374  -30.358 10.169  1.000 46.270  0 113 LYS A CD  1 
ATOM   752  C CE  . LYS A 1 109 ? 14.358  -31.765 10.775  1.000 48.240  0 113 LYS A CE  1 
ATOM   753  N NZ  . LYS A 1 109 ? 15.358  -32.660 10.134  1.000 50.610  0 113 LYS A NZ  1 
ATOM   754  N N   . GLY A 1 110 ? 10.990  -29.920 6.612   1.000 43.640  0 114 GLY A N   1 
ATOM   755  C CA  . GLY A 1 110 ? 9.550   -29.982 6.735   1.000 41.220  0 114 GLY A CA  1 
ATOM   756  C C   . GLY A 1 110 ? 8.795   -29.454 5.530   1.000 43.070  0 114 GLY A C   1 
ATOM   757  O O   . GLY A 1 110 ? 7.779   -28.776 5.685   1.000 48.780  0 114 GLY A O   1 
ATOM   758  N N   . GLU A 1 111 ? 9.264   -29.756 4.323   1.000 41.610  0 115 GLU A N   1 
ATOM   759  C CA  . GLU A 1 111 ? 8.514   -29.364 3.136   1.000 45.080  0 115 GLU A CA  1 
ATOM   760  C C   . GLU A 1 111 ? 7.261   -30.225 2.998   1.000 52.350  0 115 GLU A C   1 
ATOM   761  O O   . GLU A 1 111 ? 7.215   -31.369 3.464   1.000 44.330  0 115 GLU A O   1 
ATOM   762  C CB  . GLU A 1 111 ? 9.371   -29.512 1.876   1.000 44.980  0 115 GLU A CB  1 
ATOM   763  C CG  . GLU A 1 111 ? 10.643  -28.677 1.885   1.000 42.580  0 115 GLU A CG  1 
ATOM   764  C CD  . GLU A 1 111 ? 11.641  -29.128 0.849   1.000 45.100  0 115 GLU A CD  1 
ATOM   765  O OE1 . GLU A 1 111 ? 12.709  -28.478 0.723   1.000 45.170  0 115 GLU A OE1 1 
ATOM   766  O OE2 . GLU A 1 111 ? 11.367  -30.143 0.170   1.000 46.000  0 115 GLU A OE2 1 
ATOM   767  N N   . THR A 1 112 ? 6.231   -29.660 2.371   1.000 50.010  0 116 THR A N   1 
ATOM   768  C CA  . THR A 1 112 ? 5.156   -30.496 1.862   1.000 45.970  0 116 THR A CA  1 
ATOM   769  C C   . THR A 1 112 ? 5.623   -31.165 0.578   1.000 45.070  0 116 THR A C   1 
ATOM   770  O O   . THR A 1 112 ? 6.636   -30.780 -0.012  1.000 42.830  0 116 THR A O   1 
ATOM   771  C CB  . THR A 1 112 ? 3.888   -29.680 1.595   1.000 52.920  0 116 THR A CB  1 
ATOM   772  O OG1 . THR A 1 112 ? 4.122   -28.775 0.508   1.000 50.260  0 116 THR A OG1 1 
ATOM   773  C CG2 . THR A 1 112 ? 3.469   -28.898 2.834   1.000 49.870  0 116 THR A CG2 1 
ATOM   774  N N   . GLU A 1 113 ? 4.875   -32.175 0.129   1.000 46.440  0 117 GLU A N   1 
ATOM   775  C CA  . GLU A 1 113 ? 5.251   -32.829 -1.122  1.000 46.840  0 117 GLU A CA  1 
ATOM   776  C C   . GLU A 1 113 ? 5.117   -31.864 -2.295  1.000 47.300  0 117 GLU A C   1 
ATOM   777  O O   . GLU A 1 113 ? 5.937   -31.888 -3.220  1.000 45.810  0 117 GLU A O   1 
ATOM   778  C CB  . GLU A 1 113 ? 4.416   -34.091 -1.356  1.000 47.290  0 117 GLU A CB  1 
ATOM   779  C CG  . GLU A 1 113 ? 4.464   -35.117 -0.220  1.000 51.010  0 117 GLU A CG  1 
ATOM   780  C CD  . GLU A 1 113 ? 5.852   -35.707 -0.007  1.000 53.300  0 117 GLU A CD  1 
ATOM   781  O OE1 . GLU A 1 113 ? 6.226   -35.932 1.164   1.000 50.960  0 117 GLU A OE1 1 
ATOM   782  O OE2 . GLU A 1 113 ? 6.569   -35.943 -1.007  1.000 51.890  0 117 GLU A OE2 1 
ATOM   783  N N   . GLU A 1 114 ? 4.107   -30.986 -2.261  1.000 50.470  0 118 GLU A N   1 
ATOM   784  C CA  . GLU A 1 114 ? 3.995   -29.968 -3.304  1.000 45.480  0 118 GLU A CA  1 
ATOM   785  C C   . GLU A 1 114 ? 5.194   -29.027 -3.279  1.000 50.220  0 118 GLU A C   1 
ATOM   786  O O   . GLU A 1 114 ? 5.770   -28.716 -4.328  1.000 48.400  0 118 GLU A O   1 
ATOM   787  C CB  . GLU A 1 114 ? 2.688   -29.176 -3.163  1.000 45.160  0 118 GLU A CB  1 
ATOM   788  C CG  . GLU A 1 114 ? 2.651   -27.952 -4.083  1.000 49.380  0 118 GLU A CG  1 
ATOM   789  C CD  . GLU A 1 114 ? 1.302   -27.233 -4.133  1.000 62.620  0 118 GLU A CD  1 
ATOM   790  O OE1 . GLU A 1 114 ? 0.367   -27.617 -3.401  1.000 60.010  0 118 GLU A OE1 1 
ATOM   791  O OE2 . GLU A 1 114 ? 1.186   -26.268 -4.921  1.000 66.790  0 118 GLU A OE2 1 
ATOM   792  N N   . GLU A 1 115 ? 5.590   -28.568 -2.089  1.000 49.600  0 119 GLU A N   1 
ATOM   793  C CA  . GLU A 1 115 ? 6.769   -27.713 -1.992  1.000 51.800  0 119 GLU A CA  1 
ATOM   794  C C   . GLU A 1 115 ? 8.033   -28.451 -2.422  1.000 43.010  0 119 GLU A C   1 
ATOM   795  O O   . GLU A 1 115 ? 8.937   -27.842 -3.006  1.000 48.590  0 119 GLU A O   1 
ATOM   796  C CB  . GLU A 1 115 ? 6.920   -27.188 -0.565  1.000 51.020  0 119 GLU A CB  1 
ATOM   797  C CG  . GLU A 1 115 ? 5.885   -26.156 -0.182  1.000 58.450  0 119 GLU A CG  1 
ATOM   798  C CD  . GLU A 1 115 ? 5.826   -25.924 1.310   1.000 54.850  0 119 GLU A CD  1 
ATOM   799  O OE1 . GLU A 1 115 ? 5.177   -24.949 1.741   1.000 60.230  0 119 GLU A OE1 1 
ATOM   800  O OE2 . GLU A 1 115 ? 6.427   -26.720 2.052   1.000 49.410  0 119 GLU A OE2 1 
ATOM   801  N N   . TYR A 1 116 ? 8.111   -29.754 -2.139  1.000 45.930  0 120 TYR A N   1 
ATOM   802  C CA  . TYR A 1 116 ? 9.284   -30.538 -2.513  1.000 43.490  0 120 TYR A CA  1 
ATOM   803  C C   . TYR A 1 116 ? 9.500   -30.508 -4.020  1.000 47.460  0 120 TYR A C   1 
ATOM   804  O O   . TYR A 1 116 ? 10.608  -30.236 -4.495  1.000 43.480  0 120 TYR A O   1 
ATOM   805  C CB  . TYR A 1 116 ? 9.129   -31.980 -2.026  1.000 43.360  0 120 TYR A CB  1 
ATOM   806  C CG  . TYR A 1 116 ? 10.217  -32.912 -2.550  1.000 41.620  0 120 TYR A CG  1 
ATOM   807  C CD1 . TYR A 1 116 ? 11.426  -33.041 -1.882  1.000 43.790  0 120 TYR A CD1 1 
ATOM   808  C CD2 . TYR A 1 116 ? 10.028  -33.661 -3.712  1.000 44.840  0 120 TYR A CD2 1 
ATOM   809  C CE1 . TYR A 1 116 ? 12.428  -33.890 -2.354  1.000 40.620  0 120 TYR A CE1 1 
ATOM   810  C CE2 . TYR A 1 116 ? 11.031  -34.515 -4.196  1.000 43.260  0 120 TYR A CE2 1 
ATOM   811  C CZ  . TYR A 1 116 ? 12.228  -34.617 -3.514  1.000 45.450  0 120 TYR A CZ  1 
ATOM   812  O OH  . TYR A 1 116 ? 13.227  -35.458 -3.977  1.000 42.310  0 120 TYR A OH  1 
ATOM   813  N N   . TRP A 1 117 ? 8.447   -30.791 -4.792  1.000 47.330  0 121 TRP A N   1 
ATOM   814  C CA  . TRP A 1 117 ? 8.602   -30.863 -6.240  1.000 46.730  0 121 TRP A CA  1 
ATOM   815  C C   . TRP A 1 117 ? 8.739   -29.478 -6.859  1.000 49.600  0 121 TRP A C   1 
ATOM   816  O O   . TRP A 1 117 ? 9.402   -29.329 -7.894  1.000 53.430  0 121 TRP A O   1 
ATOM   817  C CB  . TRP A 1 117 ? 7.427   -31.632 -6.852  1.000 53.210  0 121 TRP A CB  1 
ATOM   818  C CG  . TRP A 1 117 ? 7.436   -33.098 -6.477  1.000 46.860  0 121 TRP A CG  1 
ATOM   819  C CD1 . TRP A 1 117 ? 6.584   -33.732 -5.617  1.000 49.620  0 121 TRP A CD1 1 
ATOM   820  C CD2 . TRP A 1 117 ? 8.352   -34.098 -6.940  1.000 46.910  0 121 TRP A CD2 1 
ATOM   821  N NE1 . TRP A 1 117 ? 6.909   -35.063 -5.522  1.000 46.680  0 121 TRP A NE1 1 
ATOM   822  C CE2 . TRP A 1 117 ? 7.989   -35.314 -6.326  1.000 49.620  0 121 TRP A CE2 1 
ATOM   823  C CE3 . TRP A 1 117 ? 9.442   -34.084 -7.817  1.000 48.620  0 121 TRP A CE3 1 
ATOM   824  C CZ2 . TRP A 1 117 ? 8.680   -36.504 -6.557  1.000 47.160  0 121 TRP A CZ2 1 
ATOM   825  C CZ3 . TRP A 1 117 ? 10.127  -35.264 -8.045  1.000 48.360  0 121 TRP A CZ3 1 
ATOM   826  C CH2 . TRP A 1 117 ? 9.742   -36.460 -7.420  1.000 43.100  0 121 TRP A CH2 1 
ATOM   827  N N   . TRP A 1 118 ? 8.126   -28.457 -6.247  1.000 46.070  0 122 TRP A N   1 
ATOM   828  C CA  . TRP A 1 118 ? 8.373   -27.086 -6.682  1.000 47.230  0 122 TRP A CA  1 
ATOM   829  C C   . TRP A 1 118 ? 9.843   -26.737 -6.528  1.000 46.760  0 122 TRP A C   1 
ATOM   830  O O   . TRP A 1 118 ? 10.431  -26.114 -7.418  1.000 48.880  0 122 TRP A O   1 
ATOM   831  C CB  . TRP A 1 118 ? 7.496   -26.105 -5.892  1.000 51.780  0 122 TRP A CB  1 
ATOM   832  C CG  . TRP A 1 118 ? 7.750   -24.634 -6.202  1.000 51.590  0 122 TRP A CG  1 
ATOM   833  C CD1 . TRP A 1 118 ? 7.137   -23.877 -7.163  1.000 60.060  0 122 TRP A CD1 1 
ATOM   834  C CD2 . TRP A 1 118 ? 8.671   -23.756 -5.531  1.000 52.400  0 122 TRP A CD2 1 
ATOM   835  N NE1 . TRP A 1 118 ? 7.623   -22.590 -7.136  1.000 55.670  0 122 TRP A NE1 1 
ATOM   836  C CE2 . TRP A 1 118 ? 8.564   -22.489 -6.144  1.000 56.140  0 122 TRP A CE2 1 
ATOM   837  C CE3 . TRP A 1 118 ? 9.577   -23.921 -4.475  1.000 56.440  0 122 TRP A CE3 1 
ATOM   838  C CZ2 . TRP A 1 118 ? 9.326   -21.390 -5.733  1.000 63.320  0 122 TRP A CZ2 1 
ATOM   839  C CZ3 . TRP A 1 118 ? 10.334  -22.825 -4.068  1.000 58.110  0 122 TRP A CZ3 1 
ATOM   840  C CH2 . TRP A 1 118 ? 10.205  -21.579 -4.699  1.000 58.190  0 122 TRP A CH2 1 
ATOM   841  N N   . CYS A 1 119 ? 10.458  -27.160 -5.416  1.000 44.470  0 123 CYS A N   1 
ATOM   842  C CA  . CYS A 1 119 ? 11.874  -26.883 -5.181  1.000 47.970  0 123 CYS A CA  1 
ATOM   843  C C   . CYS A 1 119 ? 12.744  -27.536 -6.244  1.000 54.210  0 123 CYS A C   1 
ATOM   844  O O   . CYS A 1 119 ? 13.688  -26.920 -6.750  1.000 54.840  0 123 CYS A O   1 
ATOM   845  C CB  . CYS A 1 119 ? 12.293  -27.366 -3.786  1.000 51.640  0 123 CYS A CB  1 
ATOM   846  S SG  . CYS A 1 119 ? 11.840  -26.257 -2.423  1.000 49.360  0 123 CYS A SG  1 
ATOM   847  N N   . VAL A 1 120 ? 12.462  -28.802 -6.574  1.000 49.090  0 124 VAL A N   1 
ATOM   848  C CA  . VAL A 1 120 ? 13.202  -29.458 -7.651  1.000 54.850  0 124 VAL A CA  1 
ATOM   849  C C   . VAL A 1 120 ? 13.049  -28.670 -8.946  1.000 53.210  0 124 VAL A C   1 
ATOM   850  O O   . VAL A 1 120 ? 14.024  -28.428 -9.669  1.000 54.340  0 124 VAL A O   1 
ATOM   851  C CB  . VAL A 1 120 ? 12.737  -30.913 -7.831  1.000 46.280  0 124 VAL A CB  1 
ATOM   852  C CG1 . VAL A 1 120 ? 13.529  -31.578 -8.950  1.000 43.150  0 124 VAL A CG1 1 
ATOM   853  C CG2 . VAL A 1 120 ? 12.883  -31.697 -6.533  1.000 42.380  0 124 VAL A CG2 1 
ATOM   854  N N   . GLU A 1 121 ? 11.817  -28.253 -9.252  1.000 44.710  0 125 GLU A N   1 
ATOM   855  C CA  . GLU A 1 121 ? 11.564  -27.516 -10.486 1.000 52.150  0 125 GLU A CA  1 
ATOM   856  C C   . GLU A 1 121 ? 12.372  -26.225 -10.550 1.000 55.460  0 125 GLU A C   1 
ATOM   857  O O   . GLU A 1 121 ? 12.771  -25.797 -11.641 1.000 53.290  0 125 GLU A O   1 
ATOM   858  C CB  . GLU A 1 121 ? 10.070  -27.216 -10.619 1.000 57.230  0 125 GLU A CB  1 
ATOM   859  C CG  . GLU A 1 121 ? 9.220   -28.436 -10.936 1.000 56.120  0 125 GLU A CG  1 
ATOM   860  C CD  . GLU A 1 121 ? 9.217   -28.774 -12.410 1.000 64.230  0 125 GLU A CD  1 
ATOM   861  O OE1 . GLU A 1 121 ? 8.791   -29.892 -12.762 1.000 61.220  0 125 GLU A OE1 1 
ATOM   862  O OE2 . GLU A 1 121 ? 9.632   -27.913 -13.218 1.000 67.850  0 125 GLU A OE2 1 
ATOM   863  N N   . GLN A 1 122 ? 12.639  -25.595 -9.400  1.000 53.560  0 126 GLN A N   1 
ATOM   864  C CA  . GLN A 1 122 ? 13.365  -24.328 -9.415  1.000 57.380  0 126 GLN A CA  1 
ATOM   865  C C   . GLN A 1 122 ? 14.814  -24.483 -9.865  1.000 53.890  0 126 GLN A C   1 
ATOM   866  O O   . GLN A 1 122 ? 15.415  -23.498 -10.309 1.000 54.650  0 126 GLN A O   1 
ATOM   867  C CB  . GLN A 1 122 ? 13.322  -23.665 -8.035  1.000 57.970  0 126 GLN A CB  1 
ATOM   868  C CG  . GLN A 1 122 ? 11.916  -23.407 -7.485  1.000 53.480  0 126 GLN A CG  1 
ATOM   869  C CD  . GLN A 1 122 ? 10.941  -22.928 -8.533  1.000 55.770  0 126 GLN A CD  1 
ATOM   870  O OE1 . GLN A 1 122 ? 11.076  -21.825 -9.064  1.000 54.570  0 126 GLN A OE1 1 
ATOM   871  N NE2 . GLN A 1 122 ? 9.935   -23.755 -8.832  1.000 51.940  0 126 GLN A NE2 1 
ATOM   872  N N   . THR A 1 123 ? 15.392  -25.684 -9.764  1.000 52.220  0 127 THR A N   1 
ATOM   873  C CA  . THR A 1 123 ? 16.779  -25.879 -10.179 1.000 52.190  0 127 THR A CA  1 
ATOM   874  C C   . THR A 1 123 ? 16.922  -26.059 -11.686 1.000 48.880  0 127 THR A C   1 
ATOM   875  O O   . THR A 1 123 ? 18.047  -26.018 -12.194 1.000 49.290  0 127 THR A O   1 
ATOM   876  C CB  . THR A 1 123 ? 17.414  -27.089 -9.459  1.000 51.050  0 127 THR A CB  1 
ATOM   877  O OG1 . THR A 1 123 ? 16.933  -28.311 -10.030 1.000 46.800  0 127 THR A OG1 1 
ATOM   878  C CG2 . THR A 1 123 ? 17.095  -27.080 -7.967  1.000 49.180  0 127 THR A CG2 1 
ATOM   879  N N   . LEU A 1 124 ? 15.821  -26.252 -12.409 1.000 47.840  0 128 LEU A N   1 
ATOM   880  C CA  . LEU A 1 124 ? 15.871  -26.493 -13.844 1.000 50.210  0 128 LEU A CA  1 
ATOM   881  C C   . LEU A 1 124 ? 15.889  -25.215 -14.669 1.000 58.810  0 128 LEU A C   1 
ATOM   882  O O   . LEU A 1 124 ? 16.148  -25.277 -15.877 1.000 53.690  0 128 LEU A O   1 
ATOM   883  C CB  . LEU A 1 124 ? 14.679  -27.351 -14.264 1.000 45.440  0 128 LEU A CB  1 
ATOM   884  C CG  . LEU A 1 124 ? 14.594  -28.680 -13.522 1.000 56.130  0 128 LEU A CG  1 
ATOM   885  C CD1 . LEU A 1 124 ? 13.440  -29.507 -14.068 1.000 60.910  0 128 LEU A CD1 1 
ATOM   886  C CD2 . LEU A 1 124 ? 15.913  -29.443 -13.619 1.000 53.010  0 128 LEU A CD2 1 
ATOM   887  N N   . SER A 1 125 ? 15.614  -24.068 -14.057 1.000 54.620  0 129 SER A N   1 
ATOM   888  C CA  . SER A 1 125 ? 15.615  -22.809 -14.777 1.000 59.030  0 129 SER A CA  1 
ATOM   889  C C   . SER A 1 125 ? 16.023  -21.713 -13.813 1.000 61.570  0 129 SER A C   1 
ATOM   890  O O   . SER A 1 125 ? 15.629  -21.724 -12.645 1.000 66.340  0 129 SER A O   1 
ATOM   891  C CB  . SER A 1 125 ? 14.242  -22.495 -15.384 1.000 65.590  0 129 SER A CB  1 
ATOM   892  O OG  . SER A 1 125 ? 13.425  -21.815 -14.450 1.000 71.170  0 129 SER A OG  1 
ATOM   893  N N   . GLY A 1 126 ? 16.817  -20.775 -14.308 1.000 60.300  0 130 GLY A N   1 
ATOM   894  C CA  . GLY A 1 126 ? 17.234  -19.652 -13.512 1.000 68.340  0 130 GLY A CA  1 
ATOM   895  C C   . GLY A 1 126 ? 17.072  -18.359 -14.276 1.000 74.400  0 130 GLY A C   1 
ATOM   896  O O   . GLY A 1 126 ? 16.647  -18.344 -15.437 1.000 70.210  0 130 GLY A O   1 
ATOM   897  N N   . PRO A 1 127 ? 17.399  -17.244 -13.627 1.000 81.630  0 131 PRO A N   1 
ATOM   898  C CA  . PRO A 1 127 ? 17.355  -15.951 -14.315 1.000 80.760  0 131 PRO A CA  1 
ATOM   899  C C   . PRO A 1 127 ? 18.194  -15.981 -15.584 1.000 79.590  0 131 PRO A C   1 
ATOM   900  O O   . PRO A 1 127 ? 19.215  -16.670 -15.658 1.000 78.660  0 131 PRO A O   1 
ATOM   901  C CB  . PRO A 1 127 ? 17.937  -14.983 -13.280 1.000 77.900  0 131 PRO A CB  1 
ATOM   902  C CG  . PRO A 1 127 ? 17.672  -15.637 -11.966 1.000 80.750  0 131 PRO A CG  1 
ATOM   903  C CD  . PRO A 1 127 ? 17.782  -17.112 -12.211 1.000 79.690  0 131 PRO A CD  1 
ATOM   904  N N   . ASN A 1 128 ? 17.727  -15.249 -16.600 1.000 73.590  0 132 ASN A N   1 
ATOM   905  C CA  . ASN A 1 128 ? 18.466  -15.048 -17.845 1.000 74.900  0 132 ASN A CA  1 
ATOM   906  C C   . ASN A 1 128 ? 18.530  -16.312 -18.698 1.000 71.610  0 132 ASN A C   1 
ATOM   907  O O   . ASN A 1 128 ? 19.504  -16.528 -19.422 1.000 69.050  0 132 ASN A O   1 
ATOM   908  C CB  . ASN A 1 128 ? 19.882  -14.539 -17.568 1.000 80.290  0 132 ASN A CB  1 
ATOM   909  C CG  . ASN A 1 128 ? 20.198  -13.273 -18.301 1.000 86.810  0 132 ASN A CG  1 
ATOM   910  O OD1 . ASN A 1 128 ? 19.582  -12.955 -19.320 1.000 94.330  0 132 ASN A OD1 1 
ATOM   911  N ND2 . ASN A 1 128 ? 21.174  -12.532 -17.791 1.000 85.840  0 132 ASN A ND2 1 
ATOM   912  N N   . GLY A 1 129 ? 17.505  -17.157 -18.631 1.000 69.390  0 133 GLY A N   1 
ATOM   913  C CA  . GLY A 1 129 ? 17.528  -18.377 -19.412 1.000 69.170  0 133 GLY A CA  1 
ATOM   914  C C   . GLY A 1 129 ? 18.548  -19.397 -18.964 1.000 64.190  0 133 GLY A C   1 
ATOM   915  O O   . GLY A 1 129 ? 18.981  -20.222 -19.773 1.000 64.120  0 133 GLY A O   1 
ATOM   916  N N   . TRP A 1 130 ? 18.961  -19.349 -17.698 1.000 61.430  0 134 TRP A N   1 
ATOM   917  C CA  . TRP A 1 130 ? 19.833  -20.374 -17.140 1.000 62.510  0 134 TRP A CA  1 
ATOM   918  C C   . TRP A 1 130 ? 19.152  -21.736 -17.211 1.000 62.570  0 134 TRP A C   1 
ATOM   919  O O   . TRP A 1 130 ? 18.023  -21.900 -16.739 1.000 57.230  0 134 TRP A O   1 
ATOM   920  C CB  . TRP A 1 130 ? 20.170  -20.023 -15.689 1.000 60.200  0 134 TRP A CB  1 
ATOM   921  C CG  . TRP A 1 130 ? 21.324  -20.780 -15.078 1.000 55.810  0 134 TRP A CG  1 
ATOM   922  C CD1 . TRP A 1 130 ? 22.599  -20.325 -14.913 1.000 61.440  0 134 TRP A CD1 1 
ATOM   923  C CD2 . TRP A 1 130 ? 21.297  -22.104 -14.523 1.000 55.260  0 134 TRP A CD2 1 
ATOM   924  N NE1 . TRP A 1 130 ? 23.370  -21.282 -14.301 1.000 59.770  0 134 TRP A NE1 1 
ATOM   925  C CE2 . TRP A 1 130 ? 22.593  -22.384 -14.051 1.000 60.090  0 134 TRP A CE2 1 
ATOM   926  C CE3 . TRP A 1 130 ? 20.305  -23.080 -14.386 1.000 56.860  0 134 TRP A CE3 1 
ATOM   927  C CZ2 . TRP A 1 130 ? 22.920  -23.594 -13.449 1.000 51.000  0 134 TRP A CZ2 1 
ATOM   928  C CZ3 . TRP A 1 130 ? 20.635  -24.285 -13.796 1.000 48.870  0 134 TRP A CZ3 1 
ATOM   929  C CH2 . TRP A 1 130 ? 21.933  -24.534 -13.336 1.000 47.370  0 134 TRP A CH2 1 
ATOM   930  N N   . THR A 1 131 ? 19.827  -22.707 -17.827 1.000 61.190  0 135 THR A N   1 
ATOM   931  C CA  . THR A 1 131 ? 19.400  -24.099 -17.796 1.000 55.820  0 135 THR A CA  1 
ATOM   932  C C   . THR A 1 131 ? 20.598  -24.984 -17.491 1.000 57.770  0 135 THR A C   1 
ATOM   933  O O   . THR A 1 131 ? 21.727  -24.666 -17.881 1.000 56.220  0 135 THR A O   1 
ATOM   934  C CB  . THR A 1 131 ? 18.759  -24.553 -19.122 1.000 57.770  0 135 THR A CB  1 
ATOM   935  O OG1 . THR A 1 131 ? 19.718  -24.481 -20.187 1.000 57.300  0 135 THR A OG1 1 
ATOM   936  C CG2 . THR A 1 131 ? 17.534  -23.703 -19.465 1.000 53.660  0 135 THR A CG2 1 
ATOM   937  N N   . PRO A 1 132 ? 20.386  -26.099 -16.797 1.000 53.130  0 136 PRO A N   1 
ATOM   938  C CA  . PRO A 1 132 ? 21.515  -26.971 -16.454 1.000 53.210  0 136 PRO A CA  1 
ATOM   939  C C   . PRO A 1 132 ? 22.085  -27.684 -17.672 1.000 49.350  0 136 PRO A C   1 
ATOM   940  O O   . PRO A 1 132 ? 21.388  -27.957 -18.652 1.000 50.640  0 136 PRO A O   1 
ATOM   941  C CB  . PRO A 1 132 ? 20.900  -27.976 -15.470 1.000 56.020  0 136 PRO A CB  1 
ATOM   942  C CG  . PRO A 1 132 ? 19.453  -28.023 -15.849 1.000 51.350  0 136 PRO A CG  1 
ATOM   943  C CD  . PRO A 1 132 ? 19.110  -26.611 -16.267 1.000 52.900  0 136 PRO A CD  1 
ATOM   944  N N   . ASN A 1 133 ? 23.377  -27.997 -17.600 1.000 50.720  0 137 ASN A N   1 
ATOM   945  C CA  . ASN A 1 133 ? 23.974  -28.933 -18.544 1.000 48.440  0 137 ASN A CA  1 
ATOM   946  C C   . ASN A 1 133 ? 24.492  -30.177 -17.831 1.000 52.840  0 137 ASN A C   1 
ATOM   947  O O   . ASN A 1 133 ? 25.114  -31.038 -18.469 1.000 48.410  0 137 ASN A O   1 
ATOM   948  C CB  . ASN A 1 133 ? 25.078  -28.254 -19.376 1.000 44.480  0 137 ASN A CB  1 
ATOM   949  C CG  . ASN A 1 133 ? 26.202  -27.669 -18.524 1.000 42.040  0 137 ASN A CG  1 
ATOM   950  O OD1 . ASN A 1 133 ? 26.383  -28.046 -17.367 1.000 44.460  0 137 ASN A OD1 1 
ATOM   951  N ND2 . ASN A 1 133 ? 26.975  -26.762 -19.107 1.000 46.280  0 137 ASN A ND2 1 
ATOM   952  N N   . LEU A 1 134 ? 24.219  -30.292 -16.526 1.000 46.450  0 138 LEU A N   1 
ATOM   953  C CA  . LEU A 1 134 ? 24.630  -31.403 -15.676 1.000 43.420  0 138 LEU A CA  1 
ATOM   954  C C   . LEU A 1 134 ? 23.588  -31.598 -14.578 1.000 45.090  0 138 LEU A C   1 
ATOM   955  O O   . LEU A 1 134 ? 23.048  -30.621 -14.049 1.000 44.340  0 138 LEU A O   1 
ATOM   956  C CB  . LEU A 1 134 ? 26.003  -31.134 -15.038 1.000 44.840  0 138 LEU A CB  1 
ATOM   957  C CG  . LEU A 1 134 ? 27.249  -31.117 -15.925 1.000 46.040  0 138 LEU A CG  1 
ATOM   958  C CD1 . LEU A 1 134 ? 28.398  -30.408 -15.211 1.000 44.980  0 138 LEU A CD1 1 
ATOM   959  C CD2 . LEU A 1 134 ? 27.642  -32.539 -16.284 1.000 45.230  0 138 LEU A CD2 1 
ATOM   960  N N   . LEU A 1 135 ? 23.311  -32.856 -14.235 1.000 44.320  0 139 LEU A N   1 
ATOM   961  C CA  . LEU A 1 135 ? 22.472  -33.201 -13.092 1.000 43.910  0 139 LEU A CA  1 
ATOM   962  C C   . LEU A 1 135 ? 23.299  -33.917 -12.033 1.000 46.150  0 139 LEU A C   1 
ATOM   963  O O   . LEU A 1 135 ? 24.150  -34.750 -12.360 1.000 40.790  0 139 LEU A O   1 
ATOM   964  C CB  . LEU A 1 135 ? 21.294  -34.095 -13.498 1.000 38.490  0 139 LEU A CB  1 
ATOM   965  C CG  . LEU A 1 135 ? 20.402  -33.570 -14.627 1.000 38.250  0 139 LEU A CG  1 
ATOM   966  C CD1 . LEU A 1 135 ? 19.346  -34.602 -14.979 1.000 42.630  0 139 LEU A CD1 1 
ATOM   967  C CD2 . LEU A 1 135 ? 19.765  -32.245 -14.221 1.000 41.280  0 139 LEU A CD2 1 
ATOM   968  N N   . LEU A 1 136 ? 23.038  -33.589 -10.764 1.000 44.610  0 140 LEU A N   1 
ATOM   969  C CA  . LEU A 1 136 ? 23.626  -34.269 -9.609  1.000 39.700  0 140 LEU A CA  1 
ATOM   970  C C   . LEU A 1 136 ? 22.481  -34.721 -8.712  1.000 41.530  0 140 LEU A C   1 
ATOM   971  O O   . LEU A 1 136 ? 21.819  -33.892 -8.075  1.000 44.720  0 140 LEU A O   1 
ATOM   972  C CB  . LEU A 1 136 ? 24.593  -33.356 -8.848  1.000 40.300  0 140 LEU A CB  1 
ATOM   973  C CG  . LEU A 1 136 ? 25.549  -34.041 -7.865  1.000 42.840  0 140 LEU A CG  1 
ATOM   974  C CD1 . LEU A 1 136 ? 26.812  -33.200 -7.672  1.000 39.910  0 140 LEU A CD1 1 
ATOM   975  C CD2 . LEU A 1 136 ? 24.898  -34.352 -6.510  1.000 39.000  0 140 LEU A CD2 1 
ATOM   976  N N   . ASP A 1 137 ? 22.251  -36.030 -8.651  1.000 34.890  0 141 ASP A N   1 
ATOM   977  C CA  . ASP A 1 137 ? 21.003  -36.566 -8.127  1.000 37.480  0 141 ASP A CA  1 
ATOM   978  C C   . ASP A 1 137 ? 21.286  -37.563 -7.014  1.000 40.030  0 141 ASP A C   1 
ATOM   979  O O   . ASP A 1 137 ? 22.350  -38.198 -6.966  1.000 35.980  0 141 ASP A O   1 
ATOM   980  C CB  . ASP A 1 137 ? 20.180  -37.236 -9.253  1.000 41.550  0 141 ASP A CB  1 
ATOM   981  C CG  . ASP A 1 137 ? 18.675  -37.312 -8.943  1.000 47.920  0 141 ASP A CG  1 
ATOM   982  O OD1 . ASP A 1 137 ? 18.223  -36.866 -7.864  1.000 37.000  0 141 ASP A OD1 1 
ATOM   983  O OD2 . ASP A 1 137 ? 17.938  -37.845 -9.797  1.000 44.430  0 141 ASP A OD2 1 
ATOM   984  N N   . ASP A 1 138 ? 20.316  -37.690 -6.119  1.000 40.280  0 142 ASP A N   1 
ATOM   985  C CA  . ASP A 1 138 ? 20.394  -38.580 -4.964  1.000 37.690  0 142 ASP A CA  1 
ATOM   986  C C   . ASP A 1 138 ? 19.000  -39.181 -4.814  1.000 40.840  0 142 ASP A C   1 
ATOM   987  O O   . ASP A 1 138 ? 18.148  -38.605 -4.143  1.000 37.660  0 142 ASP A O   1 
ATOM   988  C CB  . ASP A 1 138 ? 20.831  -37.817 -3.718  1.000 38.520  0 142 ASP A CB  1 
ATOM   989  C CG  . ASP A 1 138 ? 20.961  -38.703 -2.487  1.000 43.720  0 142 ASP A CG  1 
ATOM   990  O OD1 . ASP A 1 138 ? 20.458  -39.849 -2.492  1.000 40.760  0 142 ASP A OD1 1 
ATOM   991  O OD2 . ASP A 1 138 ? 21.555  -38.237 -1.491  1.000 40.530  0 142 ASP A OD2 1 
ATOM   992  N N   . GLY A 1 139 ? 18.774  -40.330 -5.446  1.000 38.400  0 143 GLY A N   1 
ATOM   993  C CA  . GLY A 1 139 ? 17.496  -41.013 -5.356  1.000 39.680  0 143 GLY A CA  1 
ATOM   994  C C   . GLY A 1 139 ? 16.708  -41.083 -6.649  1.000 40.700  0 143 GLY A C   1 
ATOM   995  O O   . GLY A 1 139 ? 15.748  -41.863 -6.722  1.000 42.220  0 143 GLY A O   1 
ATOM   996  N N   . GLY A 1 140 ? 17.073  -40.302 -7.669  1.000 40.510  0 144 GLY A N   1 
ATOM   997  C CA  . GLY A 1 140 ? 16.458  -40.401 -8.978  1.000 38.640  0 144 GLY A CA  1 
ATOM   998  C C   . GLY A 1 140 ? 15.298  -39.460 -9.247  1.000 39.260  0 144 GLY A C   1 
ATOM   999  O O   . GLY A 1 140 ? 14.756  -39.489 -10.361 1.000 40.700  0 144 GLY A O   1 
ATOM   1000 N N   . ASP A 1 141 ? 14.901  -38.628 -8.275  1.000 42.110  0 145 ASP A N   1 
ATOM   1001 C CA  . ASP A 1 141 ? 13.742  -37.756 -8.474  1.000 38.650  0 145 ASP A CA  1 
ATOM   1002 C C   . ASP A 1 141 ? 14.042  -36.662 -9.489  1.000 41.240  0 145 ASP A C   1 
ATOM   1003 O O   . ASP A 1 141 ? 13.198  -36.340 -10.334 1.000 44.260  0 145 ASP A O   1 
ATOM   1004 C CB  . ASP A 1 141 ? 13.305  -37.128 -7.152  1.000 43.880  0 145 ASP A CB  1 
ATOM   1005 C CG  . ASP A 1 141 ? 12.588  -38.103 -6.241  1.000 42.830  0 145 ASP A CG  1 
ATOM   1006 O OD1 . ASP A 1 141 ? 12.249  -39.225 -6.689  1.000 39.720  0 145 ASP A OD1 1 
ATOM   1007 O OD2 . ASP A 1 141 ? 12.380  -37.741 -5.060  1.000 40.760  0 145 ASP A OD2 1 
ATOM   1008 N N   . LEU A 1 142 ? 15.223  -36.050 -9.399  1.000 42.900  0 146 LEU A N   1 
ATOM   1009 C CA  . LEU A 1 142 ? 15.576  -35.022 -10.368 1.000 42.630  0 146 LEU A CA  1 
ATOM   1010 C C   . LEU A 1 142 ? 15.702  -35.621 -11.760 1.000 40.600  0 146 LEU A C   1 
ATOM   1011 O O   . LEU A 1 142 ? 15.185  -35.060 -12.738 1.000 43.640  0 146 LEU A O   1 
ATOM   1012 C CB  . LEU A 1 142 ? 16.870  -34.322 -9.944  1.000 39.270  0 146 LEU A CB  1 
ATOM   1013 C CG  . LEU A 1 142 ? 17.526  -33.370 -10.951 1.000 42.650  0 146 LEU A CG  1 
ATOM   1014 C CD1 . LEU A 1 142 ? 16.597  -32.242 -11.334 1.000 43.540  0 146 LEU A CD1 1 
ATOM   1015 C CD2 . LEU A 1 142 ? 18.850  -32.834 -10.382 1.000 47.560  0 146 LEU A CD2 1 
ATOM   1016 N N   . THR A 1 143 ? 16.366  -36.780 -11.858 1.000 36.160  0 147 THR A N   1 
ATOM   1017 C CA  . THR A 1 143 ? 16.434  -37.514 -13.115 1.000 41.360  0 147 THR A CA  1 
ATOM   1018 C C   . THR A 1 143 ? 15.041  -37.817 -13.657 1.000 43.150  0 147 THR A C   1 
ATOM   1019 O O   . THR A 1 143 ? 14.792  -37.668 -14.859 1.000 46.100  0 147 THR A O   1 
ATOM   1020 C CB  . THR A 1 143 ? 17.219  -38.809 -12.909 1.000 44.970  0 147 THR A CB  1 
ATOM   1021 O OG1 . THR A 1 143 ? 18.539  -38.486 -12.459 1.000 44.110  0 147 THR A OG1 1 
ATOM   1022 C CG2 . THR A 1 143 ? 17.292  -39.615 -14.201 1.000 43.920  0 147 THR A CG2 1 
ATOM   1023 N N   . GLN A 1 144 ? 14.125  -38.251 -12.784 1.000 44.700  0 148 GLN A N   1 
ATOM   1024 C CA  . GLN A 1 144 ? 12.752  -38.523 -13.212 1.000 45.610  0 148 GLN A CA  1 
ATOM   1025 C C   . GLN A 1 144 ? 12.102  -37.270 -13.782 1.000 45.000  0 148 GLN A C   1 
ATOM   1026 O O   . GLN A 1 144 ? 11.534  -37.296 -14.882 1.000 50.030  0 148 GLN A O   1 
ATOM   1027 C CB  . GLN A 1 144 ? 11.926  -39.069 -12.042 1.000 37.910  0 148 GLN A CB  1 
ATOM   1028 C CG  . GLN A 1 144 ? 10.450  -39.305 -12.413 1.000 36.710  0 148 GLN A CG  1 
ATOM   1029 C CD  . GLN A 1 144 ? 9.560   -39.662 -11.227 1.000 48.840  0 148 GLN A CD  1 
ATOM   1030 O OE1 . GLN A 1 144 ? 9.987   -39.648 -10.071 1.000 46.270  0 148 GLN A OE1 1 
ATOM   1031 N NE2 . GLN A 1 144 ? 8.297   -39.965 -11.518 1.000 54.050  0 148 GLN A NE2 1 
ATOM   1032 N N   . VAL A 1 145 ? 12.194  -36.157 -13.048 1.000 50.840  0 149 VAL A N   1 
ATOM   1033 C CA  . VAL A 1 145 ? 11.540  -34.912 -13.452 1.000 51.460  0 149 VAL A CA  1 
ATOM   1034 C C   . VAL A 1 145 ? 12.017  -34.473 -14.832 1.000 50.400  0 149 VAL A C   1 
ATOM   1035 O O   . VAL A 1 145 ? 11.216  -34.088 -15.690 1.000 46.720  0 149 VAL A O   1 
ATOM   1036 C CB  . VAL A 1 145 ? 11.782  -33.814 -12.398 1.000 51.550  0 149 VAL A CB  1 
ATOM   1037 C CG1 . VAL A 1 145 ? 11.439  -32.439 -12.961 1.000 54.120  0 149 VAL A CG1 1 
ATOM   1038 C CG2 . VAL A 1 145 ? 10.965  -34.095 -11.153 1.000 51.190  0 149 VAL A CG2 1 
ATOM   1039 N N   . VAL A 1 146 ? 13.328  -34.512 -15.068 1.000 41.100  0 150 VAL A N   1 
ATOM   1040 C CA  . VAL A 1 146 ? 13.844  -34.045 -16.348 1.000 45.590  0 150 VAL A CA  1 
ATOM   1041 C C   . VAL A 1 146 ? 13.374  -34.952 -17.477 1.000 47.420  0 150 VAL A C   1 
ATOM   1042 O O   . VAL A 1 146 ? 12.880  -34.478 -18.506 1.000 49.890  0 150 VAL A O   1 
ATOM   1043 C CB  . VAL A 1 146 ? 15.377  -33.944 -16.311 1.000 42.650  0 150 VAL A CB  1 
ATOM   1044 C CG1 . VAL A 1 146 ? 15.906  -33.594 -17.697 1.000 42.350  0 150 VAL A CG1 1 
ATOM   1045 C CG2 . VAL A 1 146 ? 15.803  -32.901 -15.294 1.000 43.830  0 150 VAL A CG2 1 
ATOM   1046 N N   . HIS A 1 147 ? 13.519  -36.274 -17.300 1.000 44.230  0 151 HIS A N   1 
ATOM   1047 C CA  . HIS A 1 147 ? 13.143  -37.210 -18.357 1.000 43.710  0 151 HIS A CA  1 
ATOM   1048 C C   . HIS A 1 147 ? 11.647  -37.147 -18.650 1.000 47.720  0 151 HIS A C   1 
ATOM   1049 O O   . HIS A 1 147 ? 11.232  -37.133 -19.818 1.000 52.780  0 151 HIS A O   1 
ATOM   1050 C CB  . HIS A 1 147 ? 13.536  -38.637 -17.960 1.000 51.510  0 151 HIS A CB  1 
ATOM   1051 C CG  . HIS A 1 147 ? 14.960  -38.994 -18.264 1.000 49.180  0 151 HIS A CG  1 
ATOM   1052 N ND1 . HIS A 1 147 ? 16.002  -38.676 -17.421 1.000 49.840  0 151 HIS A ND1 1 
ATOM   1053 C CD2 . HIS A 1 147 ? 15.509  -39.675 -19.299 1.000 55.570  0 151 HIS A CD2 1 
ATOM   1054 C CE1 . HIS A 1 147 ? 17.135  -39.134 -17.930 1.000 49.550  0 151 HIS A CE1 1 
ATOM   1055 N NE2 . HIS A 1 147 ? 16.863  -39.745 -19.068 1.000 47.570  0 151 HIS A NE2 1 
ATOM   1056 N N   . GLN A 1 148 ? 10.820  -37.106 -17.609 1.000 45.240  0 152 GLN A N   1 
ATOM   1057 C CA  . GLN A 1 148 ? 9.380   -37.243 -17.807 1.000 41.070  0 152 GLN A CA  1 
ATOM   1058 C C   . GLN A 1 148 ? 8.672   -35.919 -18.052 1.000 52.270  0 152 GLN A C   1 
ATOM   1059 O O   . GLN A 1 148 ? 7.613   -35.909 -18.693 1.000 54.140  0 152 GLN A O   1 
ATOM   1060 C CB  . GLN A 1 148 ? 8.749   -37.950 -16.599 1.000 56.510  0 152 GLN A CB  1 
ATOM   1061 C CG  . GLN A 1 148 ? 9.069   -39.444 -16.526 1.000 50.300  0 152 GLN A CG  1 
ATOM   1062 C CD  . GLN A 1 148 ? 8.563   -40.103 -15.258 1.000 52.330  0 152 GLN A CD  1 
ATOM   1063 O OE1 . GLN A 1 148 ? 7.851   -39.490 -14.463 1.000 55.230  0 152 GLN A OE1 1 
ATOM   1064 N NE2 . GLN A 1 148 ? 8.941   -41.362 -15.058 1.000 49.970  0 152 GLN A NE2 1 
ATOM   1065 N N   . LYS A 1 149 ? 9.215   -34.797 -17.575 1.000 55.180  0 153 LYS A N   1 
ATOM   1066 C CA  . LYS A 1 149 ? 8.491   -33.536 -17.670 1.000 59.020  0 153 LYS A CA  1 
ATOM   1067 C C   . LYS A 1 149 ? 9.221   -32.428 -18.421 1.000 58.360  0 153 LYS A C   1 
ATOM   1068 O O   . LYS A 1 149 ? 8.563   -31.481 -18.861 1.000 57.930  0 153 LYS A O   1 
ATOM   1069 C CB  . LYS A 1 149 ? 8.112   -33.039 -16.264 1.000 56.790  0 153 LYS A CB  1 
ATOM   1070 C CG  . LYS A 1 149 ? 7.257   -34.054 -15.497 1.000 63.340  0 153 LYS A CG  1 
ATOM   1071 C CD  . LYS A 1 149 ? 6.479   -33.414 -14.366 1.000 71.730  0 153 LYS A CD  1 
ATOM   1072 C CE  . LYS A 1 149 ? 5.014   -33.811 -14.416 1.000 78.720  0 153 LYS A CE  1 
ATOM   1073 N NZ  . LYS A 1 149 ? 4.212   -33.063 -13.408 1.000 81.810  0 153 LYS A NZ  1 
ATOM   1074 N N   . HIS A 1 150 ? 10.540  -32.516 -18.597 1.000 55.820  0 154 HIS A N   1 
ATOM   1075 C CA  . HIS A 1 150 ? 11.304  -31.517 -19.354 1.000 56.780  0 154 HIS A CA  1 
ATOM   1076 C C   . HIS A 1 150 ? 12.238  -32.192 -20.355 1.000 62.870  0 154 HIS A C   1 
ATOM   1077 O O   . HIS A 1 150 ? 13.450  -31.954 -20.347 1.000 58.060  0 154 HIS A O   1 
ATOM   1078 C CB  . HIS A 1 150 ? 12.101  -30.617 -18.410 1.000 53.500  0 154 HIS A CB  1 
ATOM   1079 C CG  . HIS A 1 150 ? 11.283  -30.000 -17.322 1.000 56.400  0 154 HIS A CG  1 
ATOM   1080 N ND1 . HIS A 1 150 ? 10.696  -28.759 -17.446 1.000 64.000  0 154 HIS A ND1 1 
ATOM   1081 C CD2 . HIS A 1 150 ? 10.953  -30.452 -16.089 1.000 53.640  0 154 HIS A CD2 1 
ATOM   1082 C CE1 . HIS A 1 150 ? 10.038  -28.474 -16.336 1.000 63.050  0 154 HIS A CE1 1 
ATOM   1083 N NE2 . HIS A 1 150 ? 10.180  -29.483 -15.496 1.000 61.320  0 154 HIS A NE2 1 
ATOM   1084 N N   . PRO A 1 151 ? 11.707  -33.027 -21.255 1.000 63.960  0 155 PRO A N   1 
ATOM   1085 C CA  . PRO A 1 151 ? 12.598  -33.733 -22.191 1.000 64.760  0 155 PRO A CA  1 
ATOM   1086 C C   . PRO A 1 151 ? 13.331  -32.803 -23.153 1.000 75.270  0 155 PRO A C   1 
ATOM   1087 O O   . PRO A 1 151 ? 14.317  -33.222 -23.768 1.000 78.530  0 155 PRO A O   1 
ATOM   1088 C CB  . PRO A 1 151 ? 11.648  -34.680 -22.931 1.000 64.530  0 155 PRO A CB  1 
ATOM   1089 C CG  . PRO A 1 151 ? 10.337  -33.979 -22.896 1.000 67.250  0 155 PRO A CG  1 
ATOM   1090 C CD  . PRO A 1 151 ? 10.285  -33.228 -21.593 1.000 62.650  0 155 PRO A CD  1 
ATOM   1091 N N   . LYS A 1 152 ? 12.886  -31.552 -23.297 1.000 71.430  0 156 LYS A N   1 
ATOM   1092 C CA  . LYS A 1 152 ? 13.635  -30.569 -24.078 1.000 75.470  0 156 LYS A CA  1 
ATOM   1093 C C   . LYS A 1 152 ? 14.993  -30.267 -23.444 1.000 68.430  0 156 LYS A C   1 
ATOM   1094 O O   . LYS A 1 152 ? 15.961  -29.959 -24.152 1.000 61.360  0 156 LYS A O   1 
ATOM   1095 C CB  . LYS A 1 152 ? 12.819  -29.278 -24.220 1.000 81.730  0 156 LYS A CB  1 
ATOM   1096 C CG  . LYS A 1 152 ? 12.550  -28.516 -22.911 1.000 83.550  0 156 LYS A CG  1 
ATOM   1097 C CD  . LYS A 1 152 ? 11.295  -29.020 -22.202 1.000 76.830  0 156 LYS A CD  1 
ATOM   1098 C CE  . LYS A 1 152 ? 10.763  -27.997 -21.210 1.000 72.880  0 156 LYS A CE  1 
ATOM   1099 N NZ  . LYS A 1 152 ? 9.506   -28.507 -20.580 1.000 77.800  0 156 LYS A NZ  1 
ATOM   1100 N N   . LEU A 1 153 ? 15.081  -30.354 -22.106 1.000 65.070  0 157 LEU A N   1 
ATOM   1101 C CA  . LEU A 1 153 ? 16.333  -30.160 -21.385 1.000 58.980  0 157 LEU A CA  1 
ATOM   1102 C C   . LEU A 1 153 ? 17.326  -31.283 -21.621 1.000 58.700  0 157 LEU A C   1 
ATOM   1103 O O   . LEU A 1 153 ? 18.524  -31.067 -21.427 1.000 54.760  0 157 LEU A O   1 
ATOM   1104 C CB  . LEU A 1 153 ? 16.064  -30.066 -19.889 1.000 59.180  0 157 LEU A CB  1 
ATOM   1105 C CG  . LEU A 1 153 ? 16.034  -28.710 -19.195 1.000 67.440  0 157 LEU A CG  1 
ATOM   1106 C CD1 . LEU A 1 153 ? 14.851  -27.882 -19.657 1.000 68.780  0 157 LEU A CD1 1 
ATOM   1107 C CD2 . LEU A 1 153 ? 16.006  -28.907 -17.687 1.000 65.570  0 157 LEU A CD2 1 
ATOM   1108 N N   . LEU A 1 154 ? 16.856  -32.482 -21.989 1.000 59.040  0 158 LEU A N   1 
ATOM   1109 C CA  . LEU A 1 154 ? 17.731  -33.654 -22.022 1.000 62.930  0 158 LEU A CA  1 
ATOM   1110 C C   . LEU A 1 154 ? 18.862  -33.486 -23.030 1.000 68.900  0 158 LEU A C   1 
ATOM   1111 O O   . LEU A 1 154 ? 19.981  -33.964 -22.806 1.000 73.310  0 158 LEU A O   1 
ATOM   1112 C CB  . LEU A 1 154 ? 16.920  -34.910 -22.347 1.000 63.200  0 158 LEU A CB  1 
ATOM   1113 C CG  . LEU A 1 154 ? 16.048  -35.575 -21.279 1.000 57.390  0 158 LEU A CG  1 
ATOM   1114 C CD1 . LEU A 1 154 ? 15.053  -36.535 -21.934 1.000 59.740  0 158 LEU A CD1 1 
ATOM   1115 C CD2 . LEU A 1 154 ? 16.880  -36.302 -20.230 1.000 49.980  0 158 LEU A CD2 1 
ATOM   1116 N N   . THR A 1 155 ? 18.588  -32.820 -24.154 1.000 61.230  0 159 THR A N   1 
ATOM   1117 C CA  . THR A 1 155 ? 19.583  -32.730 -25.216 1.000 56.360  0 159 THR A CA  1 
ATOM   1118 C C   . THR A 1 155 ? 20.810  -31.947 -24.775 1.000 65.450  0 159 THR A C   1 
ATOM   1119 O O   . THR A 1 155 ? 21.929  -32.266 -25.192 1.000 68.780  0 159 THR A O   1 
ATOM   1120 C CB  . THR A 1 155 ? 18.966  -32.094 -26.463 1.000 68.250  0 159 THR A CB  1 
ATOM   1121 O OG1 . THR A 1 155 ? 17.641  -32.609 -26.657 1.000 71.450  0 159 THR A OG1 1 
ATOM   1122 C CG2 . THR A 1 155 ? 19.814  -32.404 -27.693 1.000 69.560  0 159 THR A CG2 1 
ATOM   1123 N N   . ALA A 1 156 ? 20.630  -30.941 -23.925 1.000 65.310  0 160 ALA A N   1 
ATOM   1124 C CA  . ALA A 1 156 ? 21.749  -30.140 -23.452 1.000 61.240  0 160 ALA A CA  1 
ATOM   1125 C C   . ALA A 1 156 ? 22.329  -30.637 -22.133 1.000 58.310  0 160 ALA A C   1 
ATOM   1126 O O   . ALA A 1 156 ? 23.272  -30.023 -21.623 1.000 60.940  0 160 ALA A O   1 
ATOM   1127 C CB  . ALA A 1 156 ? 21.329  -28.677 -23.309 1.000 57.480  0 160 ALA A CB  1 
ATOM   1128 N N   . ILE A 1 157 ? 21.803  -31.720 -21.566 1.000 52.870  0 161 ILE A N   1 
ATOM   1129 C CA  . ILE A 1 157 ? 22.350  -32.284 -20.336 1.000 49.280  0 161 ILE A CA  1 
ATOM   1130 C C   . ILE A 1 157 ? 23.438  -33.284 -20.708 1.000 54.120  0 161 ILE A C   1 
ATOM   1131 O O   . ILE A 1 157 ? 23.184  -34.255 -21.432 1.000 53.460  0 161 ILE A O   1 
ATOM   1132 C CB  . ILE A 1 157 ? 21.259  -32.939 -19.476 1.000 52.560  0 161 ILE A CB  1 
ATOM   1133 C CG1 . ILE A 1 157 ? 20.509  -31.866 -18.689 1.000 51.610  0 161 ILE A CG1 1 
ATOM   1134 C CG2 . ILE A 1 157 ? 21.874  -33.930 -18.488 1.000 50.180  0 161 ILE A CG2 1 
ATOM   1135 C CD1 . ILE A 1 157 ? 19.087  -32.218 -18.408 1.000 56.220  0 161 ILE A CD1 1 
ATOM   1136 N N   . LYS A 1 158 ? 24.660  -33.029 -20.229 1.000 51.750  0 162 LYS A N   1 
ATOM   1137 C CA  . LYS A 1 158 ? 25.799  -33.892 -20.528 1.000 50.450  0 162 LYS A CA  1 
ATOM   1138 C C   . LYS A 1 158 ? 25.714  -35.227 -19.790 1.000 53.860  0 162 LYS A C   1 
ATOM   1139 O O   . LYS A 1 158 ? 26.189  -36.248 -20.299 1.000 49.910  0 162 LYS A O   1 
ATOM   1140 C CB  . LYS A 1 158 ? 27.096  -33.158 -20.179 1.000 50.150  0 162 LYS A CB  1 
ATOM   1141 C CG  . LYS A 1 158 ? 27.232  -31.806 -20.904 1.000 49.240  0 162 LYS A CG  1 
ATOM   1142 C CD  . LYS A 1 158 ? 28.451  -31.023 -20.437 1.000 49.910  0 162 LYS A CD  1 
ATOM   1143 C CE  . LYS A 1 158 ? 28.819  -29.945 -21.451 1.000 50.360  0 162 LYS A CE  1 
ATOM   1144 N NZ  . LYS A 1 158 ? 29.219  -30.538 -22.754 1.000 57.110  0 162 LYS A NZ  1 
ATOM   1145 N N   . GLY A 1 159 ? 25.125  -35.239 -18.602 1.000 45.740  0 163 GLY A N   1 
ATOM   1146 C CA  . GLY A 1 159 ? 24.861  -36.485 -17.917 1.000 47.680  0 163 GLY A CA  1 
ATOM   1147 C C   . GLY A 1 159 ? 24.411  -36.210 -16.499 1.000 43.810  0 163 GLY A C   1 
ATOM   1148 O O   . GLY A 1 159 ? 24.229  -35.059 -16.099 1.000 44.470  0 163 GLY A O   1 
ATOM   1149 N N   . VAL A 1 160 ? 24.248  -37.297 -15.748 1.000 40.700  0 164 VAL A N   1 
ATOM   1150 C CA  . VAL A 1 160 ? 23.861  -37.251 -14.346 1.000 36.410  0 164 VAL A CA  1 
ATOM   1151 C C   . VAL A 1 160 ? 24.816  -38.134 -13.552 1.000 38.530  0 164 VAL A C   1 
ATOM   1152 O O   . VAL A 1 160 ? 25.196  -39.222 -14.003 1.000 40.890  0 164 VAL A O   1 
ATOM   1153 C CB  . VAL A 1 160 ? 22.400  -37.714 -14.137 1.000 39.570  0 164 VAL A CB  1 
ATOM   1154 C CG1 . VAL A 1 160 ? 22.186  -39.134 -14.703 1.000 36.770  0 164 VAL A CG1 1 
ATOM   1155 C CG2 . VAL A 1 160 ? 22.029  -37.677 -12.656 1.000 37.590  0 164 VAL A CG2 1 
ATOM   1156 N N   . SER A 1 161 ? 25.224  -37.658 -12.379 1.000 39.010  0 165 SER A N   1 
ATOM   1157 C CA  . SER A 1 161 ? 25.915  -38.499 -11.407 1.000 36.220  0 165 SER A CA  1 
ATOM   1158 C C   . SER A 1 161 ? 24.952  -38.771 -10.258 1.000 40.010  0 165 SER A C   1 
ATOM   1159 O O   . SER A 1 161 ? 24.373  -37.831 -9.702  1.000 37.220  0 165 SER A O   1 
ATOM   1160 C CB  . SER A 1 161 ? 27.200  -37.839 -10.896 1.000 39.220  0 165 SER A CB  1 
ATOM   1161 O OG  . SER A 1 161 ? 26.935  -36.588 -10.282 1.000 40.980  0 165 SER A OG  1 
ATOM   1162 N N   . GLU A 1 162 ? 24.781  -40.048 -9.907  1.000 33.510  0 166 GLU A N   1 
ATOM   1163 C CA  . GLU A 1 162 ? 23.753  -40.486 -8.968  1.000 35.420  0 166 GLU A CA  1 
ATOM   1164 C C   . GLU A 1 162 ? 24.361  -41.054 -7.685  1.000 38.550  0 166 GLU A C   1 
ATOM   1165 O O   . GLU A 1 162 ? 25.197  -41.962 -7.734  1.000 38.150  0 166 GLU A O   1 
ATOM   1166 C CB  . GLU A 1 162 ? 22.845  -41.535 -9.614  1.000 35.400  0 166 GLU A CB  1 
ATOM   1167 C CG  . GLU A 1 162 ? 21.945  -42.294 -8.611  1.000 39.960  0 166 GLU A CG  1 
ATOM   1168 C CD  . GLU A 1 162 ? 20.940  -41.400 -7.878  1.000 38.840  0 166 GLU A CD  1 
ATOM   1169 O OE1 . GLU A 1 162 ? 20.219  -40.613 -8.541  1.000 39.760  0 166 GLU A OE1 1 
ATOM   1170 O OE2 . GLU A 1 162 ? 20.863  -41.499 -6.633  1.000 35.940  0 166 GLU A OE2 1 
ATOM   1171 N N   . GLU A 1 163 ? 23.850  -40.584 -6.541  1.000 36.000  0 167 GLU A N   1 
ATOM   1172 C CA  . GLU A 1 163 ? 24.454  -40.816 -5.230  1.000 32.770  0 167 GLU A CA  1 
ATOM   1173 C C   . GLU A 1 163 ? 24.110  -42.170 -4.605  1.000 40.570  0 167 GLU A C   1 
ATOM   1174 O O   . GLU A 1 163 ? 24.953  -42.751 -3.908  1.000 34.770  0 167 GLU A O   1 
ATOM   1175 C CB  . GLU A 1 163 ? 24.028  -39.705 -4.267  1.000 34.730  0 167 GLU A CB  1 
ATOM   1176 C CG  . GLU A 1 163 ? 24.616  -39.831 -2.872  1.000 32.330  0 167 GLU A CG  1 
ATOM   1177 C CD  . GLU A 1 163 ? 26.059  -39.346 -2.787  1.000 42.070  0 167 GLU A CD  1 
ATOM   1178 O OE1 . GLU A 1 163 ? 26.658  -39.056 -3.840  1.000 40.180  0 167 GLU A OE1 1 
ATOM   1179 O OE2 . GLU A 1 163 ? 26.597  -39.272 -1.660  1.000 43.320  0 167 GLU A OE2 1 
ATOM   1180 N N   . THR A 1 164 ? 22.888  -42.682 -4.773  1.000 35.130  0 168 THR A N   1 
ATOM   1181 C CA  . THR A 1 164 ? 22.445  -43.730 -3.856  1.000 33.700  0 168 THR A CA  1 
ATOM   1182 C C   . THR A 1 164 ? 21.886  -44.954 -4.575  1.000 36.200  0 168 THR A C   1 
ATOM   1183 O O   . THR A 1 164 ? 21.529  -44.926 -5.756  1.000 38.050  0 168 THR A O   1 
ATOM   1184 C CB  . THR A 1 164 ? 21.407  -43.206 -2.839  1.000 36.110  0 168 THR A CB  1 
ATOM   1185 O OG1 . THR A 1 164 ? 21.336  -44.124 -1.728  1.000 37.390  0 168 THR A OG1 1 
ATOM   1186 C CG2 . THR A 1 164 ? 20.004  -43.062 -3.480  1.000 34.950  0 168 THR A CG2 1 
ATOM   1187 N N   . THR A 1 165 ? 21.825  -46.044 -3.804  1.000 37.440  0 169 THR A N   1 
ATOM   1188 C CA  . THR A 1 165 ? 21.477  -47.351 -4.343  1.000 40.240  0 169 THR A CA  1 
ATOM   1189 C C   . THR A 1 165 ? 20.117  -47.317 -5.037  1.000 37.330  0 169 THR A C   1 
ATOM   1190 O O   . THR A 1 165 ? 19.963  -47.833 -6.150  1.000 36.940  0 169 THR A O   1 
ATOM   1191 C CB  . THR A 1 165 ? 21.488  -48.368 -3.202  1.000 48.200  0 169 THR A CB  1 
ATOM   1192 O OG1 . THR A 1 165 ? 22.537  -48.017 -2.271  1.000 41.530  0 169 THR A OG1 1 
ATOM   1193 C CG2 . THR A 1 165 ? 21.750  -49.760 -3.746  1.000 42.110  0 169 THR A CG2 1 
ATOM   1194 N N   . THR A 1 166 ? 19.130  -46.680 -4.406  1.000 36.740  0 170 THR A N   1 
ATOM   1195 C CA  . THR A 1 166 ? 17.780  -46.619 -4.975  1.000 37.640  0 170 THR A CA  1 
ATOM   1196 C C   . THR A 1 166 ? 17.770  -45.850 -6.293  1.000 38.310  0 170 THR A C   1 
ATOM   1197 O O   . THR A 1 166 ? 17.057  -46.216 -7.232  1.000 38.770  0 170 THR A O   1 
ATOM   1198 C CB  . THR A 1 166 ? 16.823  -45.972 -3.970  1.000 37.880  0 170 THR A CB  1 
ATOM   1199 O OG1 . THR A 1 166 ? 16.525  -46.898 -2.919  1.000 38.270  0 170 THR A OG1 1 
ATOM   1200 C CG2 . THR A 1 166 ? 15.504  -45.524 -4.649  1.000 38.570  0 170 THR A CG2 1 
ATOM   1201 N N   . GLY A 1 167 ? 18.575  -44.795 -6.391  1.000 36.790  0 171 GLY A N   1 
ATOM   1202 C CA  . GLY A 1 167 ? 18.638  -44.046 -7.636  1.000 37.980  0 171 GLY A CA  1 
ATOM   1203 C C   . GLY A 1 167 ? 19.256  -44.844 -8.769  1.000 37.960  0 171 GLY A C   1 
ATOM   1204 O O   . GLY A 1 167 ? 18.783  -44.791 -9.911  1.000 40.140  0 171 GLY A O   1 
ATOM   1205 N N   . VAL A 1 168 ? 20.323  -45.592 -8.470  1.000 38.820  0 172 VAL A N   1 
ATOM   1206 C CA  . VAL A 1 168 ? 20.960  -46.444 -9.475  1.000 36.110  0 172 VAL A CA  1 
ATOM   1207 C C   . VAL A 1 168 ? 20.004  -47.537 -9.937  1.000 41.550  0 172 VAL A C   1 
ATOM   1208 O O   . VAL A 1 168 ? 19.922  -47.845 -11.133 1.000 40.730  0 172 VAL A O   1 
ATOM   1209 C CB  . VAL A 1 168 ? 22.271  -47.024 -8.911  1.000 39.770  0 172 VAL A CB  1 
ATOM   1210 C CG1 . VAL A 1 168 ? 22.911  -47.985 -9.910  1.000 45.700  0 172 VAL A CG1 1 
ATOM   1211 C CG2 . VAL A 1 168 ? 23.222  -45.889 -8.570  1.000 41.480  0 172 VAL A CG2 1 
ATOM   1212 N N   . ALA A 1 169 ? 19.244  -48.122 -9.005  1.000 38.930  0 173 ALA A N   1 
ATOM   1213 C CA  . ALA A 1 169 ? 18.232  -49.106 -9.385  1.000 42.900  0 173 ALA A CA  1 
ATOM   1214 C C   . ALA A 1 169 ? 17.231  -48.527 -10.382 1.000 41.910  0 173 ALA A C   1 
ATOM   1215 O O   . ALA A 1 169 ? 16.817  -49.209 -11.328 1.000 44.590  0 173 ALA A O   1 
ATOM   1216 C CB  . ALA A 1 169 ? 17.502  -49.615 -8.141  1.000 42.950  0 173 ALA A CB  1 
ATOM   1217 N N   . ARG A 1 170 ? 16.824  -47.272 -10.181 1.000 40.190  0 174 ARG A N   1 
ATOM   1218 C CA  . ARG A 1 170 ? 15.916  -46.619 -11.118 1.000 44.680  0 174 ARG A CA  1 
ATOM   1219 C C   . ARG A 1 170 ? 16.579  -46.366 -12.470 1.000 45.560  0 174 ARG A C   1 
ATOM   1220 O O   . ARG A 1 170 ? 15.924  -46.484 -13.516 1.000 40.880  0 174 ARG A O   1 
ATOM   1221 C CB  . ARG A 1 170 ? 15.405  -45.307 -10.524 1.000 44.260  0 174 ARG A CB  1 
ATOM   1222 C CG  . ARG A 1 170 ? 14.503  -45.501 -9.325  1.000 48.320  0 174 ARG A CG  1 
ATOM   1223 C CD  . ARG A 1 170 ? 14.154  -44.173 -8.681  1.000 42.980  0 174 ARG A CD  1 
ATOM   1224 N NE  . ARG A 1 170 ? 13.122  -43.459 -9.425  1.000 40.020  0 174 ARG A NE  1 
ATOM   1225 C CZ  . ARG A 1 170 ? 12.652  -42.262 -9.087  1.000 49.070  0 174 ARG A CZ  1 
ATOM   1226 N NH1 . ARG A 1 170 ? 13.130  -41.642 -8.017  1.000 43.880  0 174 ARG A NH1 1 
ATOM   1227 N NH2 . ARG A 1 170 ? 11.693  -41.688 -9.811  1.000 43.200  0 174 ARG A NH2 1 
ATOM   1228 N N   . LEU A 1 171 ? 17.863  -45.990 -12.471 1.000 41.430  0 175 LEU A N   1 
ATOM   1229 C CA  . LEU A 1 171 ? 18.586  -45.817 -13.733 1.000 41.740  0 175 LEU A CA  1 
ATOM   1230 C C   . LEU A 1 171 ? 18.676  -47.131 -14.500 1.000 38.120  0 175 LEU A C   1 
ATOM   1231 O O   . LEU A 1 171 ? 18.457  -47.166 -15.717 1.000 41.340  0 175 LEU A O   1 
ATOM   1232 C CB  . LEU A 1 171 ? 19.994  -45.275 -13.479 1.000 38.740  0 175 LEU A CB  1 
ATOM   1233 C CG  . LEU A 1 171 ? 20.172  -43.835 -13.005 1.000 40.670  0 175 LEU A CG  1 
ATOM   1234 C CD1 . LEU A 1 171 ? 21.633  -43.602 -12.583 1.000 39.930  0 175 LEU A CD1 1 
ATOM   1235 C CD2 . LEU A 1 171 ? 19.730  -42.837 -14.085 1.000 41.860  0 175 LEU A CD2 1 
ATOM   1236 N N   . TYR A 1 172 ? 19.045  -48.215 -13.807 1.000 44.310  0 176 TYR A N   1 
ATOM   1237 C CA  . TYR A 1 172 ? 19.125  -49.526 -14.447 1.000 41.830  0 176 TYR A CA  1 
ATOM   1238 C C   . TYR A 1 172 ? 17.809  -49.890 -15.119 1.000 47.280  0 176 TYR A C   1 
ATOM   1239 O O   . TYR A 1 172 ? 17.792  -50.418 -16.236 1.000 45.470  0 176 TYR A O   1 
ATOM   1240 C CB  . TYR A 1 172 ? 19.483  -50.596 -13.420 1.000 47.710  0 176 TYR A CB  1 
ATOM   1241 C CG  . TYR A 1 172 ? 20.935  -50.639 -13.002 1.000 56.160  0 176 TYR A CG  1 
ATOM   1242 C CD1 . TYR A 1 172 ? 21.937  -50.129 -13.816 1.000 55.330  0 176 TYR A CD1 1 
ATOM   1243 C CD2 . TYR A 1 172 ? 21.301  -51.204 -11.786 1.000 64.780  0 176 TYR A CD2 1 
ATOM   1244 C CE1 . TYR A 1 172 ? 23.267  -50.173 -13.424 1.000 58.200  0 176 TYR A CE1 1 
ATOM   1245 C CE2 . TYR A 1 172 ? 22.622  -51.255 -11.389 1.000 72.890  0 176 TYR A CE2 1 
ATOM   1246 C CZ  . TYR A 1 172 ? 23.601  -50.737 -12.209 1.000 69.790  0 176 TYR A CZ  1 
ATOM   1247 O OH  . TYR A 1 172 ? 24.914  -50.795 -11.801 1.000 80.590  0 176 TYR A OH  1 
ATOM   1248 N N   . GLU A 1 173 ? 16.692  -49.621 -14.445 1.000 45.750  0 177 GLU A N   1 
ATOM   1249 C CA  . GLU A 1 173 ? 15.396  -49.953 -15.024 1.000 46.930  0 177 GLU A CA  1 
ATOM   1250 C C   . GLU A 1 173 ? 15.068  -49.048 -16.208 1.000 46.740  0 177 GLU A C   1 
ATOM   1251 O O   . GLU A 1 173 ? 14.478  -49.499 -17.198 1.000 43.970  0 177 GLU A O   1 
ATOM   1252 C CB  . GLU A 1 173 ? 14.313  -49.877 -13.949 1.000 53.710  0 177 GLU A CB  1 
ATOM   1253 C CG  . GLU A 1 173 ? 14.272  -51.106 -13.049 1.000 66.470  0 177 GLU A CG  1 
ATOM   1254 C CD  . GLU A 1 173 ? 14.000  -52.401 -13.821 1.000 75.010  0 177 GLU A CD  1 
ATOM   1255 O OE1 . GLU A 1 173 ? 14.874  -53.294 -13.842 1.000 72.390  0 177 GLU A OE1 1 
ATOM   1256 O OE2 . GLU A 1 173 ? 12.907  -52.526 -14.406 1.000 73.540  0 177 GLU A OE2 1 
ATOM   1257 N N   . MET A 1 174 ? 15.457  -47.773 -16.141 1.000 47.730  0 178 MET A N   1 
ATOM   1258 C CA  . MET A 1 174 ? 15.286  -46.901 -17.300 1.000 40.680  0 178 MET A CA  1 
ATOM   1259 C C   . MET A 1 174 ? 16.085  -47.415 -18.494 1.000 44.660  0 178 MET A C   1 
ATOM   1260 O O   . MET A 1 174 ? 15.568  -47.493 -19.617 1.000 47.120  0 178 MET A O   1 
ATOM   1261 C CB  . MET A 1 174 ? 15.697  -45.470 -16.945 1.000 46.950  0 178 MET A CB  1 
ATOM   1262 C CG  . MET A 1 174 ? 14.750  -44.798 -15.962 1.000 55.560  0 178 MET A CG  1 
ATOM   1263 S SD  . MET A 1 174 ? 15.385  -43.210 -15.391 1.000 55.470  0 178 MET A SD  1 
ATOM   1264 C CE  . MET A 1 174 ? 15.271  -42.309 -16.924 1.000 40.080  0 178 MET A CE  1 
ATOM   1265 N N   . ALA A 1 175 ? 17.352  -47.781 -18.268 1.000 46.030  0 179 ALA A N   1 
ATOM   1266 C CA  . ALA A 1 175 ? 18.196  -48.255 -19.361 1.000 42.060  0 179 ALA A CA  1 
ATOM   1267 C C   . ALA A 1 175 ? 17.632  -49.528 -19.979 1.000 46.740  0 179 ALA A C   1 
ATOM   1268 O O   . ALA A 1 175 ? 17.523  -49.642 -21.206 1.000 48.220  0 179 ALA A O   1 
ATOM   1269 C CB  . ALA A 1 175 ? 19.615  -48.486 -18.854 1.000 43.260  0 179 ALA A CB  1 
ATOM   1270 N N   . LYS A 1 176 ? 17.261  -50.495 -19.135 1.000 46.270  0 180 LYS A N   1 
ATOM   1271 C CA  . LYS A 1 176 ? 16.654  -51.738 -19.606 1.000 49.760  0 180 LYS A CA  1 
ATOM   1272 C C   . LYS A 1 176 ? 15.499  -51.485 -20.569 1.000 52.840  0 180 LYS A C   1 
ATOM   1273 O O   . LYS A 1 176 ? 15.311  -52.232 -21.535 1.000 50.080  0 180 LYS A O   1 
ATOM   1274 C CB  . LYS A 1 176 ? 16.175  -52.555 -18.406 1.000 57.320  0 180 LYS A CB  1 
ATOM   1275 C CG  . LYS A 1 176 ? 15.705  -53.945 -18.750 1.000 67.610  0 180 LYS A CG  1 
ATOM   1276 C CD  . LYS A 1 176 ? 14.988  -54.587 -17.579 1.000 73.530  0 180 LYS A CD  1 
ATOM   1277 C CE  . LYS A 1 176 ? 13.862  -55.484 -18.058 1.000 76.710  0 180 LYS A CE  1 
ATOM   1278 N NZ  . LYS A 1 176 ? 13.651  -56.609 -17.112 1.000 81.380  0 180 LYS A NZ  1 
ATOM   1279 N N   . HIS A 1 177 ? 14.712  -50.441 -20.325 1.000 55.420  0 181 HIS A N   1 
ATOM   1280 C CA  . HIS A 1 177 ? 13.541  -50.163 -21.144 1.000 58.460  0 181 HIS A CA  1 
ATOM   1281 C C   . HIS A 1 177 ? 13.773  -49.056 -22.160 1.000 53.820  0 181 HIS A C   1 
ATOM   1282 O O   . HIS A 1 177 ? 12.813  -48.600 -22.787 1.000 53.170  0 181 HIS A O   1 
ATOM   1283 C CB  . HIS A 1 177 ? 12.348  -49.819 -20.251 1.000 54.710  0 181 HIS A CB  1 
ATOM   1284 C CG  . HIS A 1 177 ? 11.888  -50.969 -19.413 1.000 50.650  0 181 HIS A CG  1 
ATOM   1285 N ND1 . HIS A 1 177 ? 12.291  -51.149 -18.106 1.000 48.710  0 181 HIS A ND1 1 
ATOM   1286 C CD2 . HIS A 1 177 ? 11.091  -52.021 -19.710 1.000 47.140  0 181 HIS A CD2 1 
ATOM   1287 C CE1 . HIS A 1 177 ? 11.741  -52.251 -17.628 1.000 49.880  0 181 HIS A CE1 1 
ATOM   1288 N NE2 . HIS A 1 177 ? 11.008  -52.798 -18.580 1.000 56.170  0 181 HIS A NE2 1 
ATOM   1289 N N   . GLY A 1 178 ? 15.019  -48.625 -22.347 1.000 52.800  0 182 GLY A N   1 
ATOM   1290 C CA  . GLY A 1 178 ? 15.306  -47.563 -23.291 1.000 55.740  0 182 GLY A CA  1 
ATOM   1291 C C   . GLY A 1 178 ? 14.822  -46.188 -22.886 1.000 57.020  0 182 GLY A C   1 
ATOM   1292 O O   . GLY A 1 178 ? 14.671  -45.322 -23.751 1.000 57.410  0 182 GLY A O   1 
ATOM   1293 N N   . GLN A 1 179 ? 14.574  -45.960 -21.592 1.000 56.280  0 183 GLN A N   1 
ATOM   1294 C CA  . GLN A 1 179 ? 14.119  -44.663 -21.106 1.000 51.430  0 183 GLN A CA  1 
ATOM   1295 C C   . GLN A 1 179 ? 15.255  -43.723 -20.730 1.000 50.890  0 183 GLN A C   1 
ATOM   1296 O O   . GLN A 1 179 ? 15.012  -42.522 -20.558 1.000 46.850  0 183 GLN A O   1 
ATOM   1297 C CB  . GLN A 1 179 ? 13.216  -44.821 -19.876 1.000 55.300  0 183 GLN A CB  1 
ATOM   1298 C CG  . GLN A 1 179 ? 12.079  -45.821 -20.017 1.000 60.930  0 183 GLN A CG  1 
ATOM   1299 C CD  . GLN A 1 179 ? 11.356  -46.049 -18.695 1.000 64.020  0 183 GLN A CD  1 
ATOM   1300 O OE1 . GLN A 1 179 ? 11.537  -47.076 -18.043 1.000 53.610  0 183 GLN A OE1 1 
ATOM   1301 N NE2 . GLN A 1 179 ? 10.526  -45.089 -18.299 1.000 69.930  0 183 GLN A NE2 1 
ATOM   1302 N N   . LEU A 1 180 ? 16.470  -44.233 -20.561 1.000 42.780  0 184 LEU A N   1 
ATOM   1303 C CA  . LEU A 1 180 ? 17.597  -43.395 -20.158 1.000 43.750  0 184 LEU A CA  1 
ATOM   1304 C C   . LEU A 1 180 ? 18.147  -42.665 -21.379 1.000 42.010  0 184 LEU A C   1 
ATOM   1305 O O   . LEU A 1 180 ? 18.554  -43.299 -22.357 1.000 48.740  0 184 LEU A O   1 
ATOM   1306 C CB  . LEU A 1 180 ? 18.682  -44.239 -19.497 1.000 40.400  0 184 LEU A CB  1 
ATOM   1307 C CG  . LEU A 1 180 ? 19.921  -43.456 -19.041 1.000 40.970  0 184 LEU A CG  1 
ATOM   1308 C CD1 . LEU A 1 180 ? 19.514  -42.366 -18.068 1.000 45.360  0 184 LEU A CD1 1 
ATOM   1309 C CD2 . LEU A 1 180 ? 20.959  -44.376 -18.428 1.000 41.860  0 184 LEU A CD2 1 
ATOM   1310 N N   . LYS A 1 181 ? 18.157  -41.332 -21.328 1.000 45.220  0 185 LYS A N   1 
ATOM   1311 C CA  . LYS A 1 181 ? 18.514  -40.525 -22.488 1.000 45.930  0 185 LYS A CA  1 
ATOM   1312 C C   . LYS A 1 181 ? 19.759  -39.677 -22.265 1.000 50.060  0 185 LYS A C   1 
ATOM   1313 O O   . LYS A 1 181 ? 20.058  -38.813 -23.099 1.000 45.540  0 185 LYS A O   1 
ATOM   1314 C CB  . LYS A 1 181 ? 17.337  -39.632 -22.889 1.000 48.900  0 185 LYS A CB  1 
ATOM   1315 C CG  . LYS A 1 181 ? 16.028  -40.386 -23.081 1.000 55.720  0 185 LYS A CG  1 
ATOM   1316 C CD  . LYS A 1 181 ? 16.141  -41.418 -24.197 1.000 60.730  0 185 LYS A CD  1 
ATOM   1317 C CE  . LYS A 1 181 ? 14.762  -41.939 -24.603 1.000 61.330  0 185 LYS A CE  1 
ATOM   1318 N NZ  . LYS A 1 181 ? 14.862  -43.064 -25.572 1.000 61.810  0 185 LYS A NZ  1 
ATOM   1319 N N   . ILE A 1 182 ? 20.479  -39.893 -21.167 1.000 53.250  0 186 ILE A N   1 
ATOM   1320 C CA  . ILE A 1 182 ? 21.755  -39.233 -20.881 1.000 48.770  0 186 ILE A CA  1 
ATOM   1321 C C   . ILE A 1 182 ? 22.702  -40.251 -20.279 1.000 42.330  0 186 ILE A C   1 
ATOM   1322 O O   . ILE A 1 182 ? 22.267  -41.251 -19.680 1.000 46.720  0 186 ILE A O   1 
ATOM   1323 C CB  . ILE A 1 182 ? 21.588  -38.037 -19.913 1.000 47.770  0 186 ILE A CB  1 
ATOM   1324 C CG1 . ILE A 1 182 ? 20.975  -38.513 -18.591 1.000 43.290  0 186 ILE A CG1 1 
ATOM   1325 C CG2 . ILE A 1 182 ? 20.742  -36.931 -20.539 1.000 44.220  0 186 ILE A CG2 1 
ATOM   1326 C CD1 . ILE A 1 182 ? 20.666  -37.404 -17.598 1.000 39.900  0 186 ILE A CD1 1 
ATOM   1327 N N   . PRO A 1 183 ? 24.013  -40.035 -20.408 1.000 42.560  0 187 PRO A N   1 
ATOM   1328 C CA  . PRO A 1 183 ? 24.969  -40.842 -19.647 1.000 47.960  0 187 PRO A CA  1 
ATOM   1329 C C   . PRO A 1 183 ? 24.746  -40.671 -18.150 1.000 40.640  0 187 PRO A C   1 
ATOM   1330 O O   . PRO A 1 183 ? 24.318  -39.616 -17.679 1.000 42.590  0 187 PRO A O   1 
ATOM   1331 C CB  . PRO A 1 183 ? 26.338  -40.291 -20.079 1.000 48.000  0 187 PRO A CB  1 
ATOM   1332 C CG  . PRO A 1 183 ? 26.080  -39.659 -21.441 1.000 42.260  0 187 PRO A CG  1 
ATOM   1333 C CD  . PRO A 1 183 ? 24.677  -39.107 -21.345 1.000 44.220  0 187 PRO A CD  1 
ATOM   1334 N N   . ALA A 1 184 ? 25.034  -41.733 -17.400 1.000 41.400  0 188 ALA A N   1 
ATOM   1335 C CA  . ALA A 1 184 ? 24.878  -41.723 -15.951 1.000 39.810  0 188 ALA A CA  1 
ATOM   1336 C C   . ALA A 1 184 ? 26.138  -42.278 -15.307 1.000 41.810  0 188 ALA A C   1 
ATOM   1337 O O   . ALA A 1 184 ? 26.641  -43.327 -15.728 1.000 43.840  0 188 ALA A O   1 
ATOM   1338 C CB  . ALA A 1 184 ? 23.652  -42.546 -15.512 1.000 42.130  0 188 ALA A CB  1 
ATOM   1339 N N   . ILE A 1 185 ? 26.655  -41.572 -14.303 1.000 37.910  0 189 ILE A N   1 
ATOM   1340 C CA  . ILE A 1 185 ? 27.743  -42.085 -13.477 1.000 37.870  0 189 ILE A CA  1 
ATOM   1341 C C   . ILE A 1 185 ? 27.161  -42.551 -12.156 1.000 41.630  0 189 ILE A C   1 
ATOM   1342 O O   . ILE A 1 185 ? 26.554  -41.765 -11.412 1.000 38.500  0 189 ILE A O   1 
ATOM   1343 C CB  . ILE A 1 185 ? 28.840  -41.042 -13.235 1.000 37.620  0 189 ILE A CB  1 
ATOM   1344 C CG1 . ILE A 1 185 ? 29.361  -40.483 -14.560 1.000 46.190  0 189 ILE A CG1 1 
ATOM   1345 C CG2 . ILE A 1 185 ? 29.969  -41.677 -12.422 1.000 38.250  0 189 ILE A CG2 1 
ATOM   1346 C CD1 . ILE A 1 185 ? 30.005  -41.507 -15.447 1.000 46.230  0 189 ILE A CD1 1 
ATOM   1347 N N   . ASN A 1 186 ? 27.366  -43.828 -11.871 1.000 38.380  0 190 ASN A N   1 
ATOM   1348 C CA  . ASN A 1 186 ? 26.941  -44.454 -10.630 1.000 36.810  0 190 ASN A CA  1 
ATOM   1349 C C   . ASN A 1 186 ? 28.001  -44.138 -9.586  1.000 37.290  0 190 ASN A C   1 
ATOM   1350 O O   . ASN A 1 186 ? 29.020  -44.826 -9.492  1.000 40.010  0 190 ASN A O   1 
ATOM   1351 C CB  . ASN A 1 186 ? 26.769  -45.955 -10.842 1.000 36.640  0 190 ASN A CB  1 
ATOM   1352 C CG  . ASN A 1 186 ? 26.488  -46.707 -9.555  1.000 38.850  0 190 ASN A CG  1 
ATOM   1353 O OD1 . ASN A 1 186 ? 26.437  -46.126 -8.472  1.000 37.430  0 190 ASN A OD1 1 
ATOM   1354 N ND2 . ASN A 1 186 ? 26.308  -48.022 -9.672  1.000 41.040  0 190 ASN A ND2 1 
ATOM   1355 N N   . VAL A 1 187 ? 27.752  -43.095 -8.793  1.000 34.490  0 191 VAL A N   1 
ATOM   1356 C CA  . VAL A 1 187 ? 28.661  -42.746 -7.709  1.000 35.200  0 191 VAL A CA  1 
ATOM   1357 C C   . VAL A 1 187 ? 28.476  -43.685 -6.522  1.000 39.840  0 191 VAL A C   1 
ATOM   1358 O O   . VAL A 1 187 ? 29.422  -43.924 -5.769  1.000 33.860  0 191 VAL A O   1 
ATOM   1359 C CB  . VAL A 1 187 ? 28.450  -41.268 -7.324  1.000 38.590  0 191 VAL A CB  1 
ATOM   1360 C CG1 . VAL A 1 187 ? 29.162  -40.900 -6.007  1.000 36.950  0 191 VAL A CG1 1 
ATOM   1361 C CG2 . VAL A 1 187 ? 28.923  -40.372 -8.458  1.000 35.650  0 191 VAL A CG2 1 
ATOM   1362 N N   . ASN A 1 188 ? 27.276  -44.252 -6.340  1.000 35.570  0 192 ASN A N   1 
ATOM   1363 C CA  . ASN A 1 188 ? 27.063  -45.141 -5.201  1.000 34.070  0 192 ASN A CA  1 
ATOM   1364 C C   . ASN A 1 188 ? 28.073  -46.281 -5.177  1.000 34.800  0 192 ASN A C   1 
ATOM   1365 O O   . ASN A 1 188 ? 28.555  -46.671 -4.106  1.000 35.260  0 192 ASN A O   1 
ATOM   1366 C CB  . ASN A 1 188 ? 25.654  -45.732 -5.216  1.000 34.350  0 192 ASN A CB  1 
ATOM   1367 C CG  . ASN A 1 188 ? 25.409  -46.620 -4.018  1.000 36.640  0 192 ASN A CG  1 
ATOM   1368 O OD1 . ASN A 1 188 ? 25.279  -46.132 -2.894  1.000 35.700  0 192 ASN A OD1 1 
ATOM   1369 N ND2 . ASN A 1 188 ? 25.368  -47.931 -4.241  1.000 35.060  0 192 ASN A ND2 1 
ATOM   1370 N N   . ASN A 1 189 ? 28.413  -46.828 -6.341  1.000 37.520  0 193 ASN A N   1 
ATOM   1371 C CA  . ASN A 1 189 ? 29.233  -48.027 -6.375  1.000 37.250  0 193 ASN A CA  1 
ATOM   1372 C C   . ASN A 1 189 ? 30.712  -47.743 -6.596  1.000 36.690  0 193 ASN A C   1 
ATOM   1373 O O   . ASN A 1 189 ? 31.461  -48.661 -6.942  1.000 40.620  0 193 ASN A O   1 
ATOM   1374 C CB  . ASN A 1 189 ? 28.710  -49.005 -7.419  1.000 35.750  0 193 ASN A CB  1 
ATOM   1375 C CG  . ASN A 1 189 ? 27.409  -49.646 -6.980  1.000 50.110  0 193 ASN A CG  1 
ATOM   1376 O OD1 . ASN A 1 189 ? 26.336  -49.211 -7.378  1.000 46.050  0 193 ASN A OD1 1 
ATOM   1377 N ND2 . ASN A 1 189 ? 27.500  -50.648 -6.112  1.000 49.430  0 193 ASN A ND2 1 
ATOM   1378 N N   . ALA A 1 190 ? 31.151  -46.504 -6.397  1.000 36.760  0 194 ALA A N   1 
ATOM   1379 C CA  . ALA A 1 190 ? 32.537  -46.315 -6.001  1.000 37.940  0 194 ALA A CA  1 
ATOM   1380 C C   . ALA A 1 190 ? 32.724  -47.047 -4.686  1.000 34.710  0 194 ALA A C   1 
ATOM   1381 O O   . ALA A 1 190 ? 31.843  -47.020 -3.827  1.000 33.780  0 194 ALA A O   1 
ATOM   1382 C CB  . ALA A 1 190 ? 32.870  -44.833 -5.837  1.000 35.640  0 194 ALA A CB  1 
ATOM   1383 N N   . VAL A 1 191 ? 33.845  -47.754 -4.546  1.000 34.150  0 195 VAL A N   1 
ATOM   1384 C CA  . VAL A 1 191 ? 34.095  -48.461 -3.294  1.000 34.090  0 195 VAL A CA  1 
ATOM   1385 C C   . VAL A 1 191 ? 34.127  -47.482 -2.131  1.000 35.650  0 195 VAL A C   1 
ATOM   1386 O O   . VAL A 1 191 ? 33.599  -47.765 -1.044  1.000 33.510  0 195 VAL A O   1 
ATOM   1387 C CB  . VAL A 1 191 ? 35.413  -49.258 -3.371  1.000 40.740  0 195 VAL A CB  1 
ATOM   1388 C CG1 . VAL A 1 191 ? 35.675  -49.950 -2.040  1.000 39.910  0 195 VAL A CG1 1 
ATOM   1389 C CG2 . VAL A 1 191 ? 35.367  -50.257 -4.506  1.000 42.380  0 195 VAL A CG2 1 
ATOM   1390 N N   . THR A 1 192 ? 34.776  -46.324 -2.331  1.000 34.250  0 196 THR A N   1 
ATOM   1391 C CA  . THR A 1 192 ? 34.903  -45.325 -1.280  1.000 35.230  0 196 THR A CA  1 
ATOM   1392 C C   . THR A 1 192 ? 33.590  -44.614 -0.984  1.000 35.750  0 196 THR A C   1 
ATOM   1393 O O   . THR A 1 192 ? 33.574  -43.686 -0.171  1.000 38.000  0 196 THR A O   1 
ATOM   1394 C CB  . THR A 1 192 ? 35.994  -44.308 -1.630  1.000 33.690  0 196 THR A CB  1 
ATOM   1395 O OG1 . THR A 1 192 ? 35.795  -43.771 -2.949  1.000 33.840  0 196 THR A OG1 1 
ATOM   1396 C CG2 . THR A 1 192 ? 37.348  -44.993 -1.568  1.000 34.520  0 196 THR A CG2 1 
ATOM   1397 N N   . LYS A 1 193 ? 32.500  -45.017 -1.631  1.000 33.460  0 197 LYS A N   1 
ATOM   1398 C CA  . LYS A 1 193 ? 31.161  -44.567 -1.265  1.000 32.440  0 197 LYS A CA  1 
ATOM   1399 C C   . LYS A 1 193 ? 30.398  -45.703 -0.606  1.000 35.690  0 197 LYS A C   1 
ATOM   1400 O O   . LYS A 1 193 ? 30.174  -45.676 0.607   1.000 34.180  0 197 LYS A O   1 
ATOM   1401 C CB  . LYS A 1 193 ? 30.417  -44.047 -2.497  1.000 33.280  0 197 LYS A CB  1 
ATOM   1402 C CG  . LYS A 1 193 ? 29.214  -43.155 -2.198  1.000 31.940  0 197 LYS A CG  1 
ATOM   1403 C CD  . LYS A 1 193 ? 27.974  -43.933 -1.763  1.000 32.550  0 197 LYS A CD  1 
ATOM   1404 C CE  . LYS A 1 193 ? 26.891  -42.981 -1.308  1.000 39.840  0 197 LYS A CE  1 
ATOM   1405 N NZ  . LYS A 1 193 ? 25.621  -43.708 -1.173  1.000 31.470  0 197 LYS A NZ  1 
ATOM   1406 N N   . SER A 1 194 ? 29.991  -46.714 -1.388  1.000 32.900  0 198 SER A N   1 
ATOM   1407 C CA  . SER A 1 194 ? 29.142  -47.795 -0.891  1.000 31.880  0 198 SER A CA  1 
ATOM   1408 C C   . SER A 1 194 ? 29.704  -48.431 0.373   1.000 34.500  0 198 SER A C   1 
ATOM   1409 O O   . SER A 1 194 ? 28.961  -48.681 1.330   1.000 39.840  0 198 SER A O   1 
ATOM   1410 C CB  . SER A 1 194 ? 28.966  -48.852 -1.982  1.000 35.690  0 198 SER A CB  1 
ATOM   1411 O OG  . SER A 1 194 ? 30.228  -49.335 -2.422  1.000 42.910  0 198 SER A OG  1 
ATOM   1412 N N   . LYS A 1 195 ? 31.015  -48.709 0.399   1.000 30.350  0 199 LYS A N   1 
ATOM   1413 C CA  . LYS A 1 195 ? 31.605  -49.447 1.511   1.000 37.070  0 199 LYS A CA  1 
ATOM   1414 C C   . LYS A 1 195 ? 32.001  -48.548 2.679   1.000 32.740  0 199 LYS A C   1 
ATOM   1415 O O   . LYS A 1 195 ? 32.578  -49.037 3.660   1.000 36.440  0 199 LYS A O   1 
ATOM   1416 C CB  . LYS A 1 195 ? 32.815  -50.257 1.031   1.000 38.980  0 199 LYS A CB  1 
ATOM   1417 C CG  . LYS A 1 195 ? 32.478  -51.263 -0.077  1.000 50.460  0 199 LYS A CG  1 
ATOM   1418 C CD  . LYS A 1 195 ? 31.702  -52.466 0.460   1.000 59.030  0 199 LYS A CD  1 
ATOM   1419 C CE  . LYS A 1 195 ? 32.653  -53.581 0.923   1.000 62.470  0 199 LYS A CE  1 
ATOM   1420 N NZ  . LYS A 1 195 ? 32.351  -54.951 0.354   1.000 58.670  0 199 LYS A NZ  1 
ATOM   1421 N N   . PHE A 1 196 ? 31.680  -47.256 2.609   1.000 34.760  0 200 PHE A N   1 
ATOM   1422 C CA  . PHE A 1 196 ? 32.057  -46.321 3.659   1.000 35.130  0 200 PHE A CA  1 
ATOM   1423 C C   . PHE A 1 196 ? 30.833  -45.536 4.116   1.000 37.800  0 200 PHE A C   1 
ATOM   1424 O O   . PHE A 1 196 ? 30.320  -45.766 5.213   1.000 32.800  0 200 PHE A O   1 
ATOM   1425 C CB  . PHE A 1 196 ? 33.190  -45.417 3.151   1.000 32.110  0 200 PHE A CB  1 
ATOM   1426 C CG  . PHE A 1 196 ? 34.490  -46.149 2.997   1.000 31.170  0 200 PHE A CG  1 
ATOM   1427 C CD1 . PHE A 1 196 ? 34.772  -46.853 1.830   1.000 36.650  0 200 PHE A CD1 1 
ATOM   1428 C CD2 . PHE A 1 196 ? 35.396  -46.217 4.058   1.000 33.890  0 200 PHE A CD2 1 
ATOM   1429 C CE1 . PHE A 1 196 ? 35.954  -47.567 1.701   1.000 35.970  0 200 PHE A CE1 1 
ATOM   1430 C CE2 . PHE A 1 196 ? 36.581  -46.946 3.938   1.000 38.340  0 200 PHE A CE2 1 
ATOM   1431 C CZ  . PHE A 1 196 ? 36.861  -47.618 2.752   1.000 37.530  0 200 PHE A CZ  1 
ATOM   1432 N N   . ASP A 1 197 ? 30.345  -44.637 3.263   1.000 28.890  0 201 ASP A N   1 
ATOM   1433 C CA  . ASP A 1 197 ? 29.092  -43.927 3.511   1.000 31.340  0 201 ASP A CA  1 
ATOM   1434 C C   . ASP A 1 197 ? 27.965  -44.871 3.941   1.000 36.350  0 201 ASP A C   1 
ATOM   1435 O O   . ASP A 1 197 ? 27.391  -44.727 5.030   1.000 34.410  0 201 ASP A O   1 
ATOM   1436 C CB  . ASP A 1 197 ? 28.727  -43.166 2.234   1.000 31.860  0 201 ASP A CB  1 
ATOM   1437 C CG  . ASP A 1 197 ? 27.391  -42.427 2.321   1.000 39.340  0 201 ASP A CG  1 
ATOM   1438 O OD1 . ASP A 1 197 ? 26.441  -42.898 2.985   1.000 42.830  0 201 ASP A OD1 1 
ATOM   1439 O OD2 . ASP A 1 197 ? 27.284  -41.385 1.647   1.000 34.250  0 201 ASP A OD2 1 
ATOM   1440 N N   . ASN A 1 198 ? 27.577  -45.794 3.061   1.000 34.820  0 202 ASN A N   1 
ATOM   1441 C CA  . ASN A 1 198 ? 26.403  -46.623 3.351   1.000 36.650  0 202 ASN A CA  1 
ATOM   1442 C C   . ASN A 1 198 ? 26.598  -47.424 4.633   1.000 37.540  0 202 ASN A C   1 
ATOM   1443 O O   . ASN A 1 198 ? 25.654  -47.621 5.411   1.000 33.900  0 202 ASN A O   1 
ATOM   1444 C CB  . ASN A 1 198 ? 26.124  -47.583 2.197   1.000 31.500  0 202 ASN A CB  1 
ATOM   1445 C CG  . ASN A 1 198 ? 25.892  -46.874 0.867   1.000 36.840  0 202 ASN A CG  1 
ATOM   1446 O OD1 . ASN A 1 198 ? 26.316  -45.736 0.662   1.000 33.750  0 202 ASN A OD1 1 
ATOM   1447 N ND2 . ASN A 1 198 ? 25.205  -47.551 -0.043  1.000 32.860  0 202 ASN A ND2 1 
ATOM   1448 N N   . LEU A 1 199 ? 27.814  -47.900 4.857   1.000 30.330  0 203 LEU A N   1 
ATOM   1449 C CA  . LEU A 1 199 ? 28.110  -48.831 5.947   1.000 31.410  0 203 LEU A CA  1 
ATOM   1450 C C   . LEU A 1 199 ? 28.467  -48.097 7.243   1.000 32.840  0 203 LEU A C   1 
ATOM   1451 O O   . LEU A 1 199 ? 27.714  -48.130 8.213   1.000 33.660  0 203 LEU A O   1 
ATOM   1452 C CB  . LEU A 1 199 ? 29.247  -49.755 5.518   1.000 32.160  0 203 LEU A CB  1 
ATOM   1453 C CG  . LEU A 1 199 ? 29.758  -50.765 6.534   1.000 35.500  0 203 LEU A CG  1 
ATOM   1454 C CD1 . LEU A 1 199 ? 28.721  -51.846 6.696   1.000 36.190  0 203 LEU A CD1 1 
ATOM   1455 C CD2 . LEU A 1 199 ? 31.063  -51.349 6.011   1.000 36.480  0 203 LEU A CD2 1 
ATOM   1456 N N   . TYR A 1 200 ? 29.653  -47.473 7.265   1.000 31.890  0 204 TYR A N   1 
ATOM   1457 C CA  . TYR A 1 200 ? 30.103  -46.779 8.470   1.000 31.620  0 204 TYR A CA  1 
ATOM   1458 C C   . TYR A 1 200 ? 29.274  -45.541 8.759   1.000 36.280  0 204 TYR A C   1 
ATOM   1459 O O   . TYR A 1 200 ? 29.111  -45.168 9.927   1.000 33.450  0 204 TYR A O   1 
ATOM   1460 C CB  . TYR A 1 200 ? 31.576  -46.374 8.343   1.000 30.190  0 204 TYR A CB  1 
ATOM   1461 C CG  . TYR A 1 200 ? 32.501  -47.532 7.978   1.000 30.960  0 204 TYR A CG  1 
ATOM   1462 C CD1 . TYR A 1 200 ? 32.497  -48.719 8.709   1.000 35.450  0 204 TYR A CD1 1 
ATOM   1463 C CD2 . TYR A 1 200 ? 33.360  -47.432 6.898   1.000 35.810  0 204 TYR A CD2 1 
ATOM   1464 C CE1 . TYR A 1 200 ? 33.354  -49.778 8.375   1.000 34.540  0 204 TYR A CE1 1 
ATOM   1465 C CE2 . TYR A 1 200 ? 34.216  -48.476 6.557   1.000 33.210  0 204 TYR A CE2 1 
ATOM   1466 C CZ  . TYR A 1 200 ? 34.203  -49.640 7.292   1.000 35.620  0 204 TYR A CZ  1 
ATOM   1467 O OH  . TYR A 1 200 ? 35.046  -50.657 6.918   1.000 38.610  0 204 TYR A OH  1 
ATOM   1468 N N   . GLY A 1 201 ? 28.792  -44.859 7.718   1.000 31.300  0 205 GLY A N   1 
ATOM   1469 C CA  . GLY A 1 201 ? 27.935  -43.711 7.955   1.000 32.450  0 205 GLY A CA  1 
ATOM   1470 C C   . GLY A 1 201 ? 26.685  -44.111 8.716   1.000 32.470  0 205 GLY A C   1 
ATOM   1471 O O   . GLY A 1 201 ? 26.385  -43.559 9.779   1.000 33.590  0 205 GLY A O   1 
ATOM   1472 N N   . CYS A 1 202 ? 25.957  -45.106 8.194   1.000 32.030  0 206 CYS A N   1 
ATOM   1473 C CA  . CYS A 1 202 ? 24.740  -45.555 8.869   1.000 34.900  0 206 CYS A CA  1 
ATOM   1474 C C   . CYS A 1 202 ? 25.039  -46.192 10.218  1.000 36.190  0 206 CYS A C   1 
ATOM   1475 O O   . CYS A 1 202 ? 24.223  -46.077 11.136  1.000 33.860  0 206 CYS A O   1 
ATOM   1476 C CB  . CYS A 1 202 ? 23.961  -46.515 7.970   1.000 32.760  0 206 CYS A CB  1 
ATOM   1477 S SG  . CYS A 1 202 ? 23.236  -45.657 6.532   1.000 38.290  0 206 CYS A SG  1 
ATOM   1478 N N   . ARG A 1 203 ? 26.212  -46.830 10.373  1.000 31.130  0 207 ARG A N   1 
ATOM   1479 C CA  . ARG A 1 203 ? 26.574  -47.415 11.664  1.000 30.550  0 207 ARG A CA  1 
ATOM   1480 C C   . ARG A 1 203 ? 26.576  -46.371 12.768  1.000 33.080  0 207 ARG A C   1 
ATOM   1481 O O   . ARG A 1 203 ? 26.382  -46.702 13.941  1.000 33.490  0 207 ARG A O   1 
ATOM   1482 C CB  . ARG A 1 203 ? 27.945  -48.098 11.582  1.000 29.640  0 207 ARG A CB  1 
ATOM   1483 C CG  . ARG A 1 203 ? 28.384  -48.815 12.871  1.000 32.810  0 207 ARG A CG  1 
ATOM   1484 C CD  . ARG A 1 203 ? 29.718  -49.561 12.692  1.000 31.520  0 207 ARG A CD  1 
ATOM   1485 N NE  . ARG A 1 203 ? 30.839  -48.639 12.504  1.000 34.170  0 207 ARG A NE  1 
ATOM   1486 C CZ  . ARG A 1 203 ? 32.076  -49.044 12.236  1.000 36.530  0 207 ARG A CZ  1 
ATOM   1487 N NH1 . ARG A 1 203 ? 32.324  -50.350 12.120  1.000 36.040  0 207 ARG A NH1 1 
ATOM   1488 N NH2 . ARG A 1 203 ? 33.060  -48.160 12.087  1.000 35.710  0 207 ARG A NH2 1 
ATOM   1489 N N   . GLU A 1 204 ? 26.803  -45.111 12.422  1.000 33.370  0 208 GLU A N   1 
ATOM   1490 C CA  . GLU A 1 204 ? 26.714  -44.050 13.410  1.000 37.420  0 208 GLU A CA  1 
ATOM   1491 C C   . GLU A 1 204 ? 25.390  -43.301 13.344  1.000 32.380  0 208 GLU A C   1 
ATOM   1492 O O   . GLU A 1 204 ? 24.841  -42.931 14.389  1.000 32.430  0 208 GLU A O   1 
ATOM   1493 C CB  . GLU A 1 204 ? 27.892  -43.078 13.237  1.000 37.100  0 208 GLU A CB  1 
ATOM   1494 C CG  . GLU A 1 204 ? 29.223  -43.733 13.684  1.000 39.150  0 208 GLU A CG  1 
ATOM   1495 C CD  . GLU A 1 204 ? 30.454  -42.868 13.524  1.000 42.390  0 208 GLU A CD  1 
ATOM   1496 O OE1 . GLU A 1 204 ? 31.506  -43.404 13.092  1.000 34.300  0 208 GLU A OE1 1 
ATOM   1497 O OE2 . GLU A 1 204 ? 30.395  -41.667 13.851  1.000 39.940  0 208 GLU A OE2 1 
ATOM   1498 N N   . SER A 1 205 ? 24.855  -43.055 12.151  1.000 32.190  0 209 SER A N   1 
ATOM   1499 C CA  . SER A 1 205 ? 23.754  -42.100 12.066  1.000 32.470  0 209 SER A CA  1 
ATOM   1500 C C   . SER A 1 205 ? 22.388  -42.735 12.303  1.000 30.540  0 209 SER A C   1 
ATOM   1501 O O   . SER A 1 205 ? 21.430  -42.007 12.584  1.000 30.610  0 209 SER A O   1 
ATOM   1502 C CB  . SER A 1 205 ? 23.782  -41.366 10.716  1.000 34.160  0 209 SER A CB  1 
ATOM   1503 O OG  . SER A 1 205 ? 23.519  -42.244 9.647   1.000 38.890  0 209 SER A OG  1 
ATOM   1504 N N   . LEU A 1 206 ? 22.271  -44.061 12.239  1.000 31.500  0 210 LEU A N   1 
ATOM   1505 C CA  . LEU A 1 206 ? 21.044  -44.698 12.723  1.000 35.280  0 210 LEU A CA  1 
ATOM   1506 C C   . LEU A 1 206 ? 20.859  -44.426 14.209  1.000 37.270  0 210 LEU A C   1 
ATOM   1507 O O   . LEU A 1 206 ? 19.779  -44.012 14.647  1.000 34.260  0 210 LEU A O   1 
ATOM   1508 C CB  . LEU A 1 206 ? 21.066  -46.204 12.464  1.000 33.080  0 210 LEU A CB  1 
ATOM   1509 C CG  . LEU A 1 206 ? 19.917  -46.995 13.148  1.000 32.500  0 210 LEU A CG  1 
ATOM   1510 C CD1 . LEU A 1 206 ? 18.518  -46.571 12.665  1.000 33.350  0 210 LEU A CD1 1 
ATOM   1511 C CD2 . LEU A 1 206 ? 20.087  -48.494 12.989  1.000 37.850  0 210 LEU A CD2 1 
ATOM   1512 N N   . LEU A 1 207 ? 21.922  -44.624 14.996  1.000 37.160  0 211 LEU A N   1 
ATOM   1513 C CA  . LEU A 1 207 ? 21.848  -44.382 16.433  1.000 39.900  0 211 LEU A CA  1 
ATOM   1514 C C   . LEU A 1 207 ? 21.524  -42.934 16.730  1.000 39.300  0 211 LEU A C   1 
ATOM   1515 O O   . LEU A 1 207 ? 20.768  -42.637 17.663  1.000 42.900  0 211 LEU A O   1 
ATOM   1516 C CB  . LEU A 1 207 ? 23.173  -44.738 17.104  1.000 38.280  0 211 LEU A CB  1 
ATOM   1517 C CG  . LEU A 1 207 ? 23.555  -46.210 17.131  1.000 42.620  0 211 LEU A CG  1 
ATOM   1518 C CD1 . LEU A 1 207 ? 24.925  -46.333 17.761  1.000 39.220  0 211 LEU A CD1 1 
ATOM   1519 C CD2 . LEU A 1 207 ? 22.521  -47.000 17.909  1.000 35.030  0 211 LEU A CD2 1 
ATOM   1520 N N   . ASP A 1 208 ? 22.151  -42.019 15.989  1.000 37.120  0 212 ASP A N   1 
ATOM   1521 C CA  . ASP A 1 208 ? 21.857  -40.600 16.112  1.000 35.170  0 212 ASP A CA  1 
ATOM   1522 C C   . ASP A 1 208 ? 20.358  -40.331 16.042  1.000 35.490  0 212 ASP A C   1 
ATOM   1523 O O   . ASP A 1 208 ? 19.790  -39.649 16.905  1.000 36.940  0 212 ASP A O   1 
ATOM   1524 C CB  . ASP A 1 208 ? 22.562  -39.839 14.995  1.000 41.540  0 212 ASP A CB  1 
ATOM   1525 C CG  . ASP A 1 208 ? 23.131  -38.535 15.459  1.000 62.540  0 212 ASP A CG  1 
ATOM   1526 O OD1 . ASP A 1 208 ? 22.575  -37.952 16.416  1.000 68.150  0 212 ASP A OD1 1 
ATOM   1527 O OD2 . ASP A 1 208 ? 24.139  -38.099 14.865  1.000 73.720  0 212 ASP A OD2 1 
ATOM   1528 N N   . GLY A 1 209 ? 19.716  -40.815 14.983  1.000 34.150  0 213 GLY A N   1 
ATOM   1529 C CA  . GLY A 1 209 ? 18.288  -40.561 14.826  1.000 36.240  0 213 GLY A CA  1 
ATOM   1530 C C   . GLY A 1 209 ? 17.466  -41.240 15.906  1.000 39.100  0 213 GLY A C   1 
ATOM   1531 O O   . GLY A 1 209 ? 16.558  -40.637 16.477  1.000 37.850  0 213 GLY A O   1 
ATOM   1532 N N   . LEU A 1 210 ? 17.795  -42.495 16.222  1.000 36.190  0 214 LEU A N   1 
ATOM   1533 C CA  . LEU A 1 210 ? 17.036  -43.212 17.246  1.000 40.850  0 214 LEU A CA  1 
ATOM   1534 C C   . LEU A 1 210 ? 17.109  -42.495 18.584  1.000 37.060  0 214 LEU A C   1 
ATOM   1535 O O   . LEU A 1 210 ? 16.088  -42.318 19.259  1.000 41.460  0 214 LEU A O   1 
ATOM   1536 C CB  . LEU A 1 210 ? 17.549  -44.650 17.398  1.000 34.870  0 214 LEU A CB  1 
ATOM   1537 C CG  . LEU A 1 210 ? 17.165  -45.707 16.367  1.000 39.200  0 214 LEU A CG  1 
ATOM   1538 C CD1 . LEU A 1 210 ? 17.809  -47.034 16.713  1.000 35.090  0 214 LEU A CD1 1 
ATOM   1539 C CD2 . LEU A 1 210 ? 15.637  -45.890 16.256  1.000 38.460  0 214 LEU A CD2 1 
ATOM   1540 N N   . LYS A 1 211 ? 18.303  -42.044 18.971  1.000 37.230  0 215 LYS A N   1 
ATOM   1541 C CA  . LYS A 1 211 ? 18.487  -41.453 20.292  1.000 33.900  0 215 LYS A CA  1 
ATOM   1542 C C   . LYS A 1 211 ? 17.944  -40.036 20.378  1.000 43.840  0 215 LYS A C   1 
ATOM   1543 O O   . LYS A 1 211 ? 17.430  -39.629 21.430  1.000 50.030  0 215 LYS A O   1 
ATOM   1544 C CB  . LYS A 1 211 ? 19.963  -41.449 20.662  1.000 41.230  0 215 LYS A CB  1 
ATOM   1545 C CG  . LYS A 1 211 ? 20.525  -42.836 20.778  1.000 49.170  0 215 LYS A CG  1 
ATOM   1546 C CD  . LYS A 1 211 ? 20.795  -43.174 22.234  1.000 70.560  0 215 LYS A CD  1 
ATOM   1547 C CE  . LYS A 1 211 ? 21.414  -44.545 22.357  1.000 78.440  0 215 LYS A CE  1 
ATOM   1548 N NZ  . LYS A 1 211 ? 20.413  -45.548 22.798  1.000 82.060  0 215 LYS A NZ  1 
ATOM   1549 N N   . ARG A 1 212 ? 18.083  -39.252 19.308  1.000 37.080  0 216 ARG A N   1 
ATOM   1550 C CA  . ARG A 1 212 ? 17.480  -37.926 19.320  1.000 38.150  0 216 ARG A CA  1 
ATOM   1551 C C   . ARG A 1 212 ? 15.960  -38.011 19.409  1.000 32.160  0 216 ARG A C   1 
ATOM   1552 O O   . ARG A 1 212 ? 15.326  -37.158 20.040  1.000 40.550  0 216 ARG A O   1 
ATOM   1553 C CB  . ARG A 1 212 ? 17.902  -37.151 18.079  1.000 47.000  0 216 ARG A CB  1 
ATOM   1554 C CG  . ARG A 1 212 ? 19.323  -36.614 18.151  1.000 67.540  0 216 ARG A CG  1 
ATOM   1555 C CD  . ARG A 1 212 ? 19.604  -35.605 17.045  1.000 77.230  0 216 ARG A CD  1 
ATOM   1556 N NE  . ARG A 1 212 ? 20.846  -35.891 16.327  1.000 78.360  0 216 ARG A NE  1 
ATOM   1557 C CZ  . ARG A 1 212 ? 21.701  -34.959 15.916  1.000 69.150  0 216 ARG A CZ  1 
ATOM   1558 N NH1 . ARG A 1 212 ? 21.453  -33.681 16.156  1.000 73.150  0 216 ARG A NH1 1 
ATOM   1559 N NH2 . ARG A 1 212 ? 22.801  -35.303 15.262  1.000 63.730  0 216 ARG A NH2 1 
ATOM   1560 N N   . ALA A 1 213 ? 15.370  -39.042 18.810  1.000 32.650  0 217 ALA A N   1 
ATOM   1561 C CA  . ALA A 1 213 ? 13.914  -39.124 18.700  1.000 40.640  0 217 ALA A CA  1 
ATOM   1562 C C   . ALA A 1 213 ? 13.267  -39.565 20.007  1.000 40.100  0 217 ALA A C   1 
ATOM   1563 O O   . ALA A 1 213 ? 12.190  -39.071 20.364  1.000 38.200  0 217 ALA A O   1 
ATOM   1564 C CB  . ALA A 1 213 ? 13.529  -40.095 17.584  1.000 35.060  0 217 ALA A CB  1 
ATOM   1565 N N   . THR A 1 214 ? 13.884  -40.521 20.704  1.000 45.030  0 218 THR A N   1 
ATOM   1566 C CA  . THR A 1 214 ? 13.294  -41.181 21.863  1.000 46.480  0 218 THR A CA  1 
ATOM   1567 C C   . THR A 1 214 ? 14.343  -41.353 22.953  1.000 51.960  0 218 THR A C   1 
ATOM   1568 O O   . THR A 1 214 ? 15.548  -41.352 22.693  1.000 43.100  0 218 THR A O   1 
ATOM   1569 C CB  . THR A 1 214 ? 12.719  -42.559 21.497  1.000 49.240  0 218 THR A CB  1 
ATOM   1570 O OG1 . THR A 1 214 ? 13.779  -43.522 21.445  1.000 53.280  0 218 THR A OG1 1 
ATOM   1571 C CG2 . THR A 1 214 ? 12.042  -42.532 20.130  1.000 43.840  0 218 THR A CG2 1 
ATOM   1572 N N   . ASP A 1 215 ? 13.883  -41.527 24.191  1.000 52.150  0 219 ASP A N   1 
ATOM   1573 C CA  . ASP A 1 215 ? 14.785  -41.956 25.254  1.000 56.490  0 219 ASP A CA  1 
ATOM   1574 C C   . ASP A 1 215 ? 14.826  -43.473 25.387  1.000 60.460  0 219 ASP A C   1 
ATOM   1575 O O   . ASP A 1 215 ? 14.976  -44.000 26.504  1.000 49.050  0 219 ASP A O   1 
ATOM   1576 C CB  . ASP A 1 215 ? 14.407  -41.297 26.578  1.000 57.870  0 219 ASP A CB  1 
ATOM   1577 C CG  . ASP A 1 215 ? 14.912  -39.867 26.671  1.000 68.790  0 219 ASP A CG  1 
ATOM   1578 O OD1 . ASP A 1 215 ? 15.774  -39.487 25.848  1.000 69.830  0 219 ASP A OD1 1 
ATOM   1579 O OD2 . ASP A 1 215 ? 14.450  -39.125 27.561  1.000 70.220  0 219 ASP A OD2 1 
ATOM   1580 N N   . VAL A 1 216 ? 14.685  -44.186 24.269  1.000 55.140  0 220 VAL A N   1 
ATOM   1581 C CA  . VAL A 1 216 ? 14.647  -45.642 24.293  1.000 55.050  0 220 VAL A CA  1 
ATOM   1582 C C   . VAL A 1 216 ? 16.057  -46.171 24.462  1.000 44.240  0 220 VAL A C   1 
ATOM   1583 O O   . VAL A 1 216 ? 17.009  -45.711 23.817  1.000 62.000  0 220 VAL A O   1 
ATOM   1584 C CB  . VAL A 1 216 ? 13.992  -46.217 23.027  1.000 61.300  0 220 VAL A CB  1 
ATOM   1585 C CG1 . VAL A 1 216 ? 15.016  -46.346 21.868  1.000 58.220  0 220 VAL A CG1 1 
ATOM   1586 C CG2 . VAL A 1 216 ? 13.363  -47.586 23.344  1.000 49.000  0 220 VAL A CG2 1 
ATOM   1587 N N   . MET A 1 217 ? 16.206  -47.108 25.372  1.000 40.270  0 221 MET A N   1 
ATOM   1588 C CA  . MET A 1 217 ? 17.485  -47.760 25.532  1.000 47.590  0 221 MET A CA  1 
ATOM   1589 C C   . MET A 1 217 ? 17.618  -48.813 24.446  1.000 41.600  0 221 MET A C   1 
ATOM   1590 O O   . MET A 1 217 ? 16.641  -49.476 24.092  1.000 37.130  0 221 MET A O   1 
ATOM   1591 C CB  . MET A 1 217 ? 17.576  -48.363 26.930  1.000 44.980  0 221 MET A CB  1 
ATOM   1592 C CG  . MET A 1 217 ? 18.782  -49.185 27.192  1.000 38.430  0 221 MET A CG  1 
ATOM   1593 S SD  . MET A 1 217 ? 19.074  -49.044 28.937  1.000 43.610  0 221 MET A SD  1 
ATOM   1594 C CE  . MET A 1 217 ? 20.713  -48.248 28.907  1.000 52.220  0 221 MET A CE  1 
ATOM   1595 N N   . ILE A 1 218 ? 18.821  -48.939 23.890  1.000 31.600  0 222 ILE A N   1 
ATOM   1596 C CA  . ILE A 1 218 ? 19.071  -50.002 22.923  1.000 31.620  0 222 ILE A CA  1 
ATOM   1597 C C   . ILE A 1 218 ? 19.352  -51.324 23.629  1.000 34.790  0 222 ILE A C   1 
ATOM   1598 O O   . ILE A 1 218 ? 18.874  -52.385 23.199  1.000 32.770  0 222 ILE A O   1 
ATOM   1599 C CB  . ILE A 1 218 ? 20.234  -49.604 21.993  1.000 30.580  0 222 ILE A CB  1 
ATOM   1600 C CG1 . ILE A 1 218 ? 19.923  -48.292 21.253  1.000 43.020  0 222 ILE A CG1 1 
ATOM   1601 C CG2 . ILE A 1 218 ? 20.555  -50.732 21.015  1.000 27.690  0 222 ILE A CG2 1 
ATOM   1602 C CD1 . ILE A 1 218 ? 18.761  -48.385 20.295  1.000 51.910  0 222 ILE A CD1 1 
ATOM   1603 N N   . ALA A 1 219 ? 20.165  -51.283 24.691  1.000 31.320  0 223 ALA A N   1 
ATOM   1604 C CA  . ALA A 1 219 ? 20.592  -52.485 25.395  1.000 35.700  0 223 ALA A CA  1 
ATOM   1605 C C   . ALA A 1 219 ? 19.388  -53.288 25.878  1.000 34.200  0 223 ALA A C   1 
ATOM   1606 O O   . ALA A 1 219 ? 18.458  -52.728 26.469  1.000 32.310  0 223 ALA A O   1 
ATOM   1607 C CB  . ALA A 1 219 ? 21.460  -52.101 26.587  1.000 31.670  0 223 ALA A CB  1 
ATOM   1608 N N   . GLY A 1 220 ? 19.418  -54.599 25.632  1.000 34.610  0 224 GLY A N   1 
ATOM   1609 C CA  . GLY A 1 220 ? 18.330  -55.487 26.025  1.000 34.000  0 224 GLY A CA  1 
ATOM   1610 C C   . GLY A 1 220 ? 17.167  -55.549 25.059  1.000 34.810  0 224 GLY A C   1 
ATOM   1611 O O   . GLY A 1 220 ? 16.309  -56.442 25.194  1.000 34.030  0 224 GLY A O   1 
ATOM   1612 N N   . LYS A 1 221 ? 17.097  -54.644 24.089  1.000 32.090  0 225 LYS A N   1 
ATOM   1613 C CA  . LYS A 1 221 ? 15.996  -54.662 23.137  1.000 31.970  0 225 LYS A CA  1 
ATOM   1614 C C   . LYS A 1 221 ? 16.207  -55.725 22.060  1.000 39.490  0 225 LYS A C   1 
ATOM   1615 O O   . LYS A 1 221 ? 17.334  -56.120 21.738  1.000 36.860  0 225 LYS A O   1 
ATOM   1616 C CB  . LYS A 1 221 ? 15.832  -53.299 22.465  1.000 34.390  0 225 LYS A CB  1 
ATOM   1617 C CG  . LYS A 1 221 ? 15.454  -52.178 23.412  1.000 34.450  0 225 LYS A CG  1 
ATOM   1618 C CD  . LYS A 1 221 ? 14.212  -52.536 24.255  1.000 38.580  0 225 LYS A CD  1 
ATOM   1619 C CE  . LYS A 1 221 ? 13.539  -51.276 24.838  1.000 38.730  0 225 LYS A CE  1 
ATOM   1620 N NZ  . LYS A 1 221 ? 14.475  -50.467 25.689  1.000 36.170  0 225 LYS A NZ  1 
ATOM   1621 N N   . VAL A 1 222 ? 15.099  -56.170 21.481  1.000 31.750  0 226 VAL A N   1 
ATOM   1622 C CA  . VAL A 1 222 ? 15.128  -56.985 20.278  1.000 31.970  0 226 VAL A CA  1 
ATOM   1623 C C   . VAL A 1 222 ? 14.871  -56.065 19.090  1.000 34.100  0 226 VAL A C   1 
ATOM   1624 O O   . VAL A 1 222 ? 13.796  -55.464 18.980  1.000 34.130  0 226 VAL A O   1 
ATOM   1625 C CB  . VAL A 1 222 ? 14.092  -58.120 20.338  1.000 33.910  0 226 VAL A CB  1 
ATOM   1626 C CG1 . VAL A 1 222 ? 14.015  -58.817 18.975  1.000 32.900  0 226 VAL A CG1 1 
ATOM   1627 C CG2 . VAL A 1 222 ? 14.473  -59.125 21.431  1.000 33.890  0 226 VAL A CG2 1 
ATOM   1628 N N   . ALA A 1 223 ? 15.865  -55.940 18.206  1.000 30.270  0 227 ALA A N   1 
ATOM   1629 C CA  . ALA A 1 223 ? 15.810  -55.011 17.086  1.000 34.990  0 227 ALA A CA  1 
ATOM   1630 C C   . ALA A 1 223 ? 15.857  -55.807 15.795  1.000 36.830  0 227 ALA A C   1 
ATOM   1631 O O   . ALA A 1 223 ? 16.718  -56.671 15.639  1.000 37.720  0 227 ALA A O   1 
ATOM   1632 C CB  . ALA A 1 223 ? 16.985  -54.018 17.131  1.000 37.010  0 227 ALA A CB  1 
ATOM   1633 N N   . LEU A 1 224 ? 14.958  -55.506 14.861  1.000 30.050  0 228 LEU A N   1 
ATOM   1634 C CA  . LEU A 1 224 ? 14.922  -56.208 13.581  1.000 30.570  0 228 LEU A CA  1 
ATOM   1635 C C   . LEU A 1 224 ? 15.342  -55.249 12.471  1.000 27.670  0 228 LEU A C   1 
ATOM   1636 O O   . LEU A 1 224 ? 14.746  -54.180 12.314  1.000 35.440  0 228 LEU A O   1 
ATOM   1637 C CB  . LEU A 1 224 ? 13.519  -56.779 13.312  1.000 31.260  0 228 LEU A CB  1 
ATOM   1638 C CG  . LEU A 1 224 ? 13.236  -57.286 11.894  1.000 34.600  0 228 LEU A CG  1 
ATOM   1639 C CD1 . LEU A 1 224 ? 14.101  -58.514 11.525  1.000 31.510  0 228 LEU A CD1 1 
ATOM   1640 C CD2 . LEU A 1 224 ? 11.734  -57.604 11.712  1.000 32.680  0 228 LEU A CD2 1 
ATOM   1641 N N   . ILE A 1 225 ? 16.364  -55.639 11.700  1.000 30.660  0 229 ILE A N   1 
ATOM   1642 C CA  . ILE A 1 225 ? 16.806  -54.899 10.521  1.000 33.090  0 229 ILE A CA  1 
ATOM   1643 C C   . ILE A 1 225 ? 16.282  -55.623 9.296   1.000 33.370  0 229 ILE A C   1 
ATOM   1644 O O   . ILE A 1 225 ? 16.603  -56.800 9.086   1.000 30.470  0 229 ILE A O   1 
ATOM   1645 C CB  . ILE A 1 225 ? 18.343  -54.786 10.451  1.000 37.230  0 229 ILE A CB  1 
ATOM   1646 C CG1 . ILE A 1 225 ? 18.945  -54.262 11.765  1.000 38.990  0 229 ILE A CG1 1 
ATOM   1647 C CG2 . ILE A 1 225 ? 18.792  -53.963 9.215   1.000 32.820  0 229 ILE A CG2 1 
ATOM   1648 C CD1 . ILE A 1 225 ? 18.429  -52.932 12.204  1.000 42.290  0 229 ILE A CD1 1 
ATOM   1649 N N   . LEU A 1 226 ? 15.497  -54.927 8.467   1.000 30.610  0 230 LEU A N   1 
ATOM   1650 C CA  . LEU A 1 226 ? 15.062  -55.496 7.190   1.000 31.260  0 230 LEU A CA  1 
ATOM   1651 C C   . LEU A 1 226 ? 16.073  -55.094 6.120   1.000 32.090  0 230 LEU A C   1 
ATOM   1652 O O   . LEU A 1 226 ? 16.224  -53.907 5.800   1.000 32.440  0 230 LEU A O   1 
ATOM   1653 C CB  . LEU A 1 226 ? 13.648  -55.037 6.826   1.000 30.640  0 230 LEU A CB  1 
ATOM   1654 C CG  . LEU A 1 226 ? 12.547  -55.235 7.885   1.000 34.780  0 230 LEU A CG  1 
ATOM   1655 C CD1 . LEU A 1 226 ? 11.177  -54.926 7.275   1.000 38.720  0 230 LEU A CD1 1 
ATOM   1656 C CD2 . LEU A 1 226 ? 12.564  -56.627 8.383   1.000 44.530  0 230 LEU A CD2 1 
ATOM   1657 N N   . GLY A 1 227 ? 16.778  -56.082 5.581   1.000 31.370  0 231 GLY A N   1 
ATOM   1658 C CA  . GLY A 1 227 ? 17.775  -55.844 4.564   1.000 31.670  0 231 GLY A CA  1 
ATOM   1659 C C   . GLY A 1 227 ? 19.163  -55.879 5.171   1.000 33.630  0 231 GLY A C   1 
ATOM   1660 O O   . GLY A 1 227 ? 19.397  -55.283 6.230   1.000 32.530  0 231 GLY A O   1 
ATOM   1661 N N   . TYR A 1 228 ? 20.075  -56.610 4.536   1.000 31.690  0 232 TYR A N   1 
ATOM   1662 C CA  . TYR A 1 228 ? 21.443  -56.766 5.020   1.000 33.010  0 232 TYR A CA  1 
ATOM   1663 C C   . TYR A 1 228 ? 22.414  -56.476 3.889   1.000 32.690  0 232 TYR A C   1 
ATOM   1664 O O   . TYR A 1 228 ? 23.381  -57.210 3.662   1.000 37.890  0 232 TYR A O   1 
ATOM   1665 C CB  . TYR A 1 228 ? 21.680  -58.158 5.618   1.000 35.590  0 232 TYR A CB  1 
ATOM   1666 C CG  . TYR A 1 228 ? 22.911  -58.249 6.538   1.000 32.760  0 232 TYR A CG  1 
ATOM   1667 C CD1 . TYR A 1 228 ? 22.925  -57.597 7.774   1.000 33.580  0 232 TYR A CD1 1 
ATOM   1668 C CD2 . TYR A 1 228 ? 24.042  -58.991 6.173   1.000 28.910  0 232 TYR A CD2 1 
ATOM   1669 C CE1 . TYR A 1 228 ? 24.026  -57.673 8.618   1.000 35.310  0 232 TYR A CE1 1 
ATOM   1670 C CE2 . TYR A 1 228 ? 25.167  -59.078 7.026   1.000 30.220  0 232 TYR A CE2 1 
ATOM   1671 C CZ  . TYR A 1 228 ? 25.142  -58.404 8.241   1.000 30.160  0 232 TYR A CZ  1 
ATOM   1672 O OH  . TYR A 1 228 ? 26.219  -58.457 9.084   1.000 34.760  0 232 TYR A OH  1 
ATOM   1673 N N   . GLY A 1 229 ? 22.132  -55.406 3.149   1.000 30.950  0 233 GLY A N   1 
ATOM   1674 C CA  . GLY A 1 229 ? 23.069  -54.827 2.214   1.000 28.970  0 233 GLY A CA  1 
ATOM   1675 C C   . GLY A 1 229 ? 23.999  -53.908 2.969   1.000 31.790  0 233 GLY A C   1 
ATOM   1676 O O   . GLY A 1 229 ? 24.217  -54.066 4.173   1.000 29.100  0 233 GLY A O   1 
ATOM   1677 N N   . ASP A 1 230 ? 24.542  -52.914 2.278   1.000 34.730  0 234 ASP A N   1 
ATOM   1678 C CA  . ASP A 1 230 ? 25.569  -52.109 2.931   1.000 31.190  0 234 ASP A CA  1 
ATOM   1679 C C   . ASP A 1 230 ? 24.993  -51.330 4.108   1.000 28.420  0 234 ASP A C   1 
ATOM   1680 O O   . ASP A 1 230 ? 25.634  -51.217 5.162   1.000 32.050  0 234 ASP A O   1 
ATOM   1681 C CB  . ASP A 1 230 ? 26.226  -51.186 1.909   1.000 33.550  0 234 ASP A CB  1 
ATOM   1682 C CG  . ASP A 1 230 ? 27.100  -51.947 0.928   1.000 37.180  0 234 ASP A CG  1 
ATOM   1683 O OD1 . ASP A 1 230 ? 27.736  -52.944 1.351   1.000 40.630  0 234 ASP A OD1 1 
ATOM   1684 O OD2 . ASP A 1 230 ? 27.157  -51.548 -0.257  1.000 34.830  0 234 ASP A OD2 1 
ATOM   1685 N N   . VAL A 1 231 ? 23.785  -50.779 3.945   1.000 28.380  0 235 VAL A N   1 
ATOM   1686 C CA  . VAL A 1 231 ? 23.165  -50.015 5.023   1.000 30.740  0 235 VAL A CA  1 
ATOM   1687 C C   . VAL A 1 231 ? 22.787  -50.931 6.180   1.000 29.880  0 235 VAL A C   1 
ATOM   1688 O O   . VAL A 1 231 ? 23.083  -50.639 7.348   1.000 32.980  0 235 VAL A O   1 
ATOM   1689 C CB  . VAL A 1 231 ? 21.934  -49.249 4.492   1.000 34.060  0 235 VAL A CB  1 
ATOM   1690 C CG1 . VAL A 1 231 ? 21.155  -48.624 5.646   1.000 32.670  0 235 VAL A CG1 1 
ATOM   1691 C CG2 . VAL A 1 231 ? 22.350  -48.190 3.481   1.000 32.900  0 235 VAL A CG2 1 
ATOM   1692 N N   . GLY A 1 232 ? 22.077  -52.026 5.880   1.000 31.710  0 236 GLY A N   1 
ATOM   1693 C CA  . GLY A 1 232 ? 21.660  -52.934 6.935   1.000 32.070  0 236 GLY A CA  1 
ATOM   1694 C C   . GLY A 1 232 ? 22.833  -53.514 7.705   1.000 32.350  0 236 GLY A C   1 
ATOM   1695 O O   . GLY A 1 232 ? 22.739  -53.736 8.912   1.000 30.690  0 236 GLY A O   1 
ATOM   1696 N N   . LYS A 1 233 ? 23.947  -53.783 7.008   1.000 31.760  0 237 LYS A N   1 
ATOM   1697 C CA  . LYS A 1 233 ? 25.164  -54.234 7.682   1.000 37.210  0 237 LYS A CA  1 
ATOM   1698 C C   . LYS A 1 233 ? 25.622  -53.218 8.721   1.000 33.890  0 237 LYS A C   1 
ATOM   1699 O O   . LYS A 1 233 ? 26.023  -53.588 9.828   1.000 31.890  0 237 LYS A O   1 
ATOM   1700 C CB  . LYS A 1 233 ? 26.292  -54.475 6.660   1.000 31.110  0 237 LYS A CB  1 
ATOM   1701 C CG  . LYS A 1 233 ? 26.212  -55.798 5.878   1.000 32.540  0 237 LYS A CG  1 
ATOM   1702 C CD  . LYS A 1 233 ? 27.253  -55.884 4.776   1.000 38.250  0 237 LYS A CD  1 
ATOM   1703 C CE  . LYS A 1 233 ? 27.284  -57.286 4.129   1.000 38.140  0 237 LYS A CE  1 
ATOM   1704 N NZ  . LYS A 1 233 ? 26.164  -57.424 3.131   1.000 33.340  0 237 LYS A NZ  1 
ATOM   1705 N N   . GLY A 1 234 ? 25.604  -51.928 8.370   1.000 30.870  0 238 GLY A N   1 
ATOM   1706 C CA  . GLY A 1 234 ? 26.021  -50.920 9.332   1.000 29.120  0 238 GLY A CA  1 
ATOM   1707 C C   . GLY A 1 234 ? 25.062  -50.819 10.495  1.000 27.450  0 238 GLY A C   1 
ATOM   1708 O O   . GLY A 1 234 ? 25.486  -50.701 11.653  1.000 30.690  0 238 GLY A O   1 
ATOM   1709 N N   . CYS A 1 235 ? 23.748  -50.855 10.200  1.000 29.640  0 239 CYS A N   1 
ATOM   1710 C CA  . CYS A 1 235 ? 22.729  -50.764 11.242  1.000 36.120  0 239 CYS A CA  1 
ATOM   1711 C C   . CYS A 1 235 ? 22.852  -51.912 12.227  1.000 32.200  0 239 CYS A C   1 
ATOM   1712 O O   . CYS A 1 235 ? 22.754  -51.710 13.440  1.000 33.760  0 239 CYS A O   1 
ATOM   1713 C CB  . CYS A 1 235 ? 21.328  -50.773 10.610  1.000 28.770  0 239 CYS A CB  1 
ATOM   1714 S SG  . CYS A 1 235 ? 21.011  -49.285 9.606   1.000 34.710  0 239 CYS A SG  1 
ATOM   1715 N N   . ALA A 1 236 ? 23.045  -53.130 11.713  1.000 31.270  0 240 ALA A N   1 
ATOM   1716 C CA  . ALA A 1 236 ? 23.184  -54.289 12.581  1.000 34.580  0 240 ALA A CA  1 
ATOM   1717 C C   . ALA A 1 236 ? 24.382  -54.130 13.506  1.000 34.380  0 240 ALA A C   1 
ATOM   1718 O O   . ALA A 1 236 ? 24.267  -54.334 14.722  1.000 31.860  0 240 ALA A O   1 
ATOM   1719 C CB  . ALA A 1 236 ? 23.310  -55.559 11.739  1.000 36.780  0 240 ALA A CB  1 
ATOM   1720 N N   . GLN A 1 237 ? 25.536  -53.730 12.947  1.000 33.550  0 241 GLN A N   1 
ATOM   1721 C CA  . GLN A 1 237 ? 26.720  -53.473 13.766  1.000 39.420  0 241 GLN A CA  1 
ATOM   1722 C C   . GLN A 1 237 ? 26.412  -52.455 14.855  1.000 37.440  0 241 GLN A C   1 
ATOM   1723 O O   . GLN A 1 237 ? 26.780  -52.639 16.024  1.000 34.240  0 241 GLN A O   1 
ATOM   1724 C CB  . GLN A 1 237 ? 27.872  -52.942 12.905  1.000 43.180  0 241 GLN A CB  1 
ATOM   1725 C CG  . GLN A 1 237 ? 28.649  -53.932 12.051  1.000 47.650  0 241 GLN A CG  1 
ATOM   1726 C CD  . GLN A 1 237 ? 29.990  -53.341 11.632  1.000 44.910  0 241 GLN A CD  1 
ATOM   1727 O OE1 . GLN A 1 237 ? 30.590  -52.603 12.392  1.000 38.660  0 241 GLN A OE1 1 
ATOM   1728 N NE2 . GLN A 1 237 ? 30.448  -53.646 10.418  1.000 55.510  0 241 GLN A NE2 1 
ATOM   1729 N N   . ALA A 1 238 ? 25.748  -51.362 14.473  1.000 37.670  0 242 ALA A N   1 
ATOM   1730 C CA  . ALA A 1 238 ? 25.461  -50.275 15.405  1.000 35.190  0 242 ALA A CA  1 
ATOM   1731 C C   . ALA A 1 238 ? 24.689  -50.774 16.616  1.000 41.090  0 242 ALA A C   1 
ATOM   1732 O O   . ALA A 1 238 ? 25.085  -50.532 17.765  1.000 32.860  0 242 ALA A O   1 
ATOM   1733 C CB  . ALA A 1 238 ? 24.665  -49.187 14.691  1.000 37.580  0 242 ALA A CB  1 
ATOM   1734 N N   . LEU A 1 239 ? 23.564  -51.457 16.368  1.000 29.900  0 243 LEU A N   1 
ATOM   1735 C CA  . LEU A 1 239 ? 22.686  -51.885 17.452  1.000 29.180  0 243 LEU A CA  1 
ATOM   1736 C C   . LEU A 1 239 ? 23.316  -53.008 18.268  1.000 31.850  0 243 LEU A C   1 
ATOM   1737 O O   . LEU A 1 239 ? 23.172  -53.045 19.499  1.000 28.500  0 243 LEU A O   1 
ATOM   1738 C CB  . LEU A 1 239 ? 21.336  -52.323 16.875  1.000 30.050  0 243 LEU A CB  1 
ATOM   1739 C CG  . LEU A 1 239 ? 20.605  -51.194 16.127  1.000 35.640  0 243 LEU A CG  1 
ATOM   1740 C CD1 . LEU A 1 239 ? 19.215  -51.643 15.680  1.000 37.080  0 243 LEU A CD1 1 
ATOM   1741 C CD2 . LEU A 1 239 ? 20.496  -49.999 17.034  1.000 35.230  0 243 LEU A CD2 1 
ATOM   1742 N N   . ARG A 1 240 ? 24.035  -53.917 17.608  1.000 36.730  0 244 ARG A N   1 
ATOM   1743 C CA  . ARG A 1 240 ? 24.693  -55.004 18.334  1.000 40.700  0 244 ARG A CA  1 
ATOM   1744 C C   . ARG A 1 240 ? 25.741  -54.471 19.305  1.000 40.010  0 244 ARG A C   1 
ATOM   1745 O O   . ARG A 1 240 ? 25.852  -54.957 20.441  1.000 34.410  0 244 ARG A O   1 
ATOM   1746 C CB  . ARG A 1 240 ? 25.326  -55.989 17.346  1.000 43.370  0 244 ARG A CB  1 
ATOM   1747 C CG  . ARG A 1 240 ? 26.238  -57.053 17.969  1.000 54.570  0 244 ARG A CG  1 
ATOM   1748 C CD  . ARG A 1 240 ? 27.595  -57.073 17.259  1.000 67.260  0 244 ARG A CD  1 
ATOM   1749 N NE  . ARG A 1 240 ? 28.486  -58.141 17.716  1.000 70.710  0 244 ARG A NE  1 
ATOM   1750 C CZ  . ARG A 1 240 ? 28.558  -59.342 17.151  1.000 74.040  0 244 ARG A CZ  1 
ATOM   1751 N NH1 . ARG A 1 240 ? 27.786  -59.639 16.111  1.000 71.270  0 244 ARG A NH1 1 
ATOM   1752 N NH2 . ARG A 1 240 ? 29.398  -60.250 17.626  1.000 74.700  0 244 ARG A NH2 1 
ATOM   1753 N N   . GLY A 1 241 ? 26.522  -53.475 18.879  1.000 37.530  0 245 GLY A N   1 
ATOM   1754 C CA  . GLY A 1 241 ? 27.505  -52.881 19.771  1.000 44.350  0 245 GLY A CA  1 
ATOM   1755 C C   . GLY A 1 241 ? 26.886  -52.285 21.019  1.000 37.100  0 245 GLY A C   1 
ATOM   1756 O O   . GLY A 1 241 ? 27.509  -52.269 22.085  1.000 39.960  0 245 GLY A O   1 
ATOM   1757 N N   . GLN A 1 242 ? 25.645  -51.837 20.922  1.000 34.350  0 246 GLN A N   1 
ATOM   1758 C CA  . GLN A 1 242 ? 24.952  -51.187 22.024  1.000 38.190  0 246 GLN A CA  1 
ATOM   1759 C C   . GLN A 1 242 ? 24.129  -52.159 22.865  1.000 36.130  0 246 GLN A C   1 
ATOM   1760 O O   . GLN A 1 242 ? 23.337  -51.717 23.701  1.000 36.750  0 246 GLN A O   1 
ATOM   1761 C CB  . GLN A 1 242 ? 24.053  -50.077 21.483  1.000 30.350  0 246 GLN A CB  1 
ATOM   1762 C CG  . GLN A 1 242 ? 24.850  -48.994 20.730  1.000 40.090  0 246 GLN A CG  1 
ATOM   1763 C CD  . GLN A 1 242 ? 25.275  -47.847 21.622  1.000 39.300  0 246 GLN A CD  1 
ATOM   1764 O OE1 . GLN A 1 242 ? 24.529  -46.890 21.800  1.000 41.180  0 246 GLN A OE1 1 
ATOM   1765 N NE2 . GLN A 1 242 ? 26.475  -47.931 22.183  1.000 34.920  0 246 GLN A NE2 1 
ATOM   1766 N N   . GLY A 1 243 ? 24.266  -53.461 22.635  1.000 37.050  0 247 GLY A N   1 
ATOM   1767 C CA  . GLY A 1 243 ? 23.650  -54.447 23.496  1.000 37.270  0 247 GLY A CA  1 
ATOM   1768 C C   . GLY A 1 243 ? 22.270  -54.932 23.095  1.000 38.450  0 247 GLY A C   1 
ATOM   1769 O O   . GLY A 1 243 ? 21.618  -55.594 23.908  1.000 34.320  0 247 GLY A O   1 
ATOM   1770 N N   . ALA A 1 244 ? 21.795  -54.635 21.887  1.000 32.190  0 248 ALA A N   1 
ATOM   1771 C CA  . ALA A 1 244 ? 20.530  -55.227 21.449  1.000 33.390  0 248 ALA A CA  1 
ATOM   1772 C C   . ALA A 1 244 ? 20.752  -56.634 20.904  1.000 31.960  0 248 ALA A C   1 
ATOM   1773 O O   . ALA A 1 244 ? 21.827  -56.961 20.375  1.000 31.260  0 248 ALA A O   1 
ATOM   1774 C CB  . ALA A 1 244 ? 19.853  -54.384 20.372  1.000 33.860  0 248 ALA A CB  1 
ATOM   1775 N N   . THR A 1 245 ? 19.724  -57.471 21.055  1.000 32.700  0 249 THR A N   1 
ATOM   1776 C CA  . THR A 1 245 ? 19.598  -58.683 20.258  1.000 37.400  0 249 THR A CA  1 
ATOM   1777 C C   . THR A 1 245 ? 19.182  -58.279 18.847  1.000 39.360  0 249 THR A C   1 
ATOM   1778 O O   . THR A 1 245 ? 18.111  -57.695 18.661  1.000 35.820  0 249 THR A O   1 
ATOM   1779 C CB  . THR A 1 245 ? 18.552  -59.620 20.865  1.000 32.700  0 249 THR A CB  1 
ATOM   1780 O OG1 . THR A 1 245 ? 18.878  -59.899 22.234  1.000 37.220  0 249 THR A OG1 1 
ATOM   1781 C CG2 . THR A 1 245 ? 18.489  -60.927 20.078  1.000 37.700  0 249 THR A CG2 1 
ATOM   1782 N N   . VAL A 1 246 ? 20.004  -58.580 17.844  1.000 29.480  0 250 VAL A N   1 
ATOM   1783 C CA  . VAL A 1 246 ? 19.745  -58.098 16.488  1.000 31.130  0 250 VAL A CA  1 
ATOM   1784 C C   . VAL A 1 246 ? 19.235  -59.252 15.635  1.000 30.540  0 250 VAL A C   1 
ATOM   1785 O O   . VAL A 1 246 ? 19.939  -60.255 15.443  1.000 33.630  0 250 VAL A O   1 
ATOM   1786 C CB  . VAL A 1 246 ? 20.994  -57.460 15.856  1.000 34.370  0 250 VAL A CB  1 
ATOM   1787 C CG1 . VAL A 1 246 ? 20.721  -57.141 14.416  1.000 34.390  0 250 VAL A CG1 1 
ATOM   1788 C CG2 . VAL A 1 246 ? 21.395  -56.186 16.610  1.000 34.510  0 250 VAL A CG2 1 
ATOM   1789 N N   . LEU A 1 247 ? 18.022  -59.094 15.107  1.000 29.580  0 251 LEU A N   1 
ATOM   1790 C CA  . LEU A 1 247 ? 17.454  -59.968 14.087  1.000 31.270  0 251 LEU A CA  1 
ATOM   1791 C C   . LEU A 1 247 ? 17.618  -59.334 12.709  1.000 34.840  0 251 LEU A C   1 
ATOM   1792 O O   . LEU A 1 247 ? 17.550  -58.116 12.573  1.000 32.090  0 251 LEU A O   1 
ATOM   1793 C CB  . LEU A 1 247 ? 15.955  -60.203 14.335  1.000 28.850  0 251 LEU A CB  1 
ATOM   1794 C CG  . LEU A 1 247 ? 15.517  -60.669 15.724  1.000 32.580  0 251 LEU A CG  1 
ATOM   1795 C CD1 . LEU A 1 247 ? 13.984  -60.765 15.798  1.000 33.600  0 251 LEU A CD1 1 
ATOM   1796 C CD2 . LEU A 1 247 ? 16.160  -62.002 16.073  1.000 38.000  0 251 LEU A CD2 1 
ATOM   1797 N N   . VAL A 1 248 ? 17.763  -60.171 11.672  1.000 32.370  0 252 VAL A N   1 
ATOM   1798 C CA  . VAL A 1 248 ? 17.911  -59.706 10.291  1.000 30.430  0 252 VAL A CA  1 
ATOM   1799 C C   . VAL A 1 248 ? 16.911  -60.448 9.400   1.000 35.850  0 252 VAL A C   1 
ATOM   1800 O O   . VAL A 1 248 ? 16.741  -61.663 9.537   1.000 33.090  0 252 VAL A O   1 
ATOM   1801 C CB  . VAL A 1 248 ? 19.357  -59.911 9.782   1.000 33.950  0 252 VAL A CB  1 
ATOM   1802 C CG1 . VAL A 1 248 ? 19.469  -59.618 8.287   1.000 32.970  0 252 VAL A CG1 1 
ATOM   1803 C CG2 . VAL A 1 248 ? 20.336  -59.024 10.571  1.000 30.220  0 252 VAL A CG2 1 
ATOM   1804 N N   . ALA A 1 249 ? 16.239  -59.718 8.499   1.000 33.710  0 253 ALA A N   1 
ATOM   1805 C CA  . ALA A 1 249 ? 15.453  -60.322 7.418   1.000 30.830  0 253 ALA A CA  1 
ATOM   1806 C C   . ALA A 1 249 ? 16.135  -60.065 6.077   1.000 34.550  0 253 ALA A C   1 
ATOM   1807 O O   . ALA A 1 249 ? 16.664  -58.975 5.840   1.000 32.930  0 253 ALA A O   1 
ATOM   1808 C CB  . ALA A 1 249 ? 14.016  -59.772 7.372   1.000 34.060  0 253 ALA A CB  1 
ATOM   1809 N N   . GLU A 1 250 ? 16.112  -61.060 5.193   1.000 35.060  0 254 GLU A N   1 
ATOM   1810 C CA  . GLU A 1 250 ? 16.733  -60.910 3.882   1.000 31.700  0 254 GLU A CA  1 
ATOM   1811 C C   . GLU A 1 250 ? 15.975  -61.757 2.864   1.000 30.910  0 254 GLU A C   1 
ATOM   1812 O O   . GLU A 1 250 ? 15.443  -62.823 3.196   1.000 36.560  0 254 GLU A O   1 
ATOM   1813 C CB  . GLU A 1 250 ? 18.210  -61.337 3.884   1.000 29.560  0 254 GLU A CB  1 
ATOM   1814 C CG  . GLU A 1 250 ? 19.238  -60.175 3.871   1.000 30.390  0 254 GLU A CG  1 
ATOM   1815 C CD  . GLU A 1 250 ? 19.227  -59.391 2.568   1.000 34.000  0 254 GLU A CD  1 
ATOM   1816 O OE1 . GLU A 1 250 ? 19.865  -58.307 2.519   1.000 34.650  0 254 GLU A OE1 1 
ATOM   1817 O OE2 . GLU A 1 250 ? 18.582  -59.845 1.595   1.000 32.550  0 254 GLU A OE2 1 
ATOM   1818 N N   . ILE A 1 251 ? 15.945  -61.273 1.619   1.000 30.420  0 255 ILE A N   1 
ATOM   1819 C CA  . ILE A 1 251 ? 15.480  -62.068 0.475   1.000 34.250  0 255 ILE A CA  1 
ATOM   1820 C C   . ILE A 1 251 ? 16.638  -62.692 -0.300  1.000 34.390  0 255 ILE A C   1 
ATOM   1821 O O   . ILE A 1 251 ? 16.406  -63.591 -1.125  1.000 31.830  0 255 ILE A O   1 
ATOM   1822 C CB  . ILE A 1 251 ? 14.634  -61.210 -0.492  1.000 36.880  0 255 ILE A CB  1 
ATOM   1823 C CG1 . ILE A 1 251 ? 15.476  -60.038 -1.033  1.000 39.140  0 255 ILE A CG1 1 
ATOM   1824 C CG2 . ILE A 1 251 ? 13.347  -60.716 0.179   1.000 35.780  0 255 ILE A CG2 1 
ATOM   1825 C CD1 . ILE A 1 251 ? 16.037  -60.261 -2.428  1.000 34.490  0 255 ILE A CD1 1 
ATOM   1826 N N   . ASP A 1 252 ? 17.866  -62.210 -0.094  1.000 33.300  0 256 ASP A N   1 
ATOM   1827 C CA  . ASP A 1 252 ? 19.040  -62.602 -0.863  1.000 34.130  0 256 ASP A CA  1 
ATOM   1828 C C   . ASP A 1 252 ? 19.803  -63.649 -0.068  1.000 32.420  0 256 ASP A C   1 
ATOM   1829 O O   . ASP A 1 252 ? 20.210  -63.365 1.070   1.000 35.080  0 256 ASP A O   1 
ATOM   1830 C CB  . ASP A 1 252 ? 19.911  -61.375 -1.131  1.000 31.360  0 256 ASP A CB  1 
ATOM   1831 C CG  . ASP A 1 252 ? 21.173  -61.674 -1.971  1.000 34.970  0 256 ASP A CG  1 
ATOM   1832 O OD1 . ASP A 1 252 ? 21.808  -62.732 -1.786  1.000 35.590  0 256 ASP A OD1 1 
ATOM   1833 O OD2 . ASP A 1 252 ? 21.529  -60.821 -2.810  1.000 36.430  0 256 ASP A OD2 1 
ATOM   1834 N N   . PRO A 1 253 ? 19.966  -64.877 -0.574  1.000 31.650  0 257 PRO A N   1 
ATOM   1835 C CA  . PRO A 1 253 ? 20.561  -65.923 0.269   1.000 31.920  0 257 PRO A CA  1 
ATOM   1836 C C   . PRO A 1 253 ? 22.022  -65.677 0.591   1.000 36.580  0 257 PRO A C   1 
ATOM   1837 O O   . PRO A 1 253 ? 22.501  -66.182 1.615   1.000 34.690  0 257 PRO A O   1 
ATOM   1838 C CB  . PRO A 1 253 ? 20.378  -67.202 -0.566  1.000 35.200  0 257 PRO A CB  1 
ATOM   1839 C CG  . PRO A 1 253 ? 20.326  -66.699 -1.981  1.000 40.190  0 257 PRO A CG  1 
ATOM   1840 C CD  . PRO A 1 253 ? 19.592  -65.387 -1.904  1.000 32.210  0 257 PRO A CD  1 
ATOM   1841 N N   . ILE A 1 254 ? 22.750  -64.933 -0.248  1.000 32.140  0 258 ILE A N   1 
ATOM   1842 C CA  . ILE A 1 254 ? 24.144  -64.618 0.081   1.000 31.210  0 258 ILE A CA  1 
ATOM   1843 C C   . ILE A 1 254 ? 24.204  -63.631 1.241   1.000 30.570  0 258 ILE A C   1 
ATOM   1844 O O   . ILE A 1 254 ? 24.958  -63.827 2.202   1.000 30.530  0 258 ILE A O   1 
ATOM   1845 C CB  . ILE A 1 254 ? 24.902  -64.079 -1.145  1.000 31.230  0 258 ILE A CB  1 
ATOM   1846 C CG1 . ILE A 1 254 ? 24.964  -65.130 -2.259  1.000 35.400  0 258 ILE A CG1 1 
ATOM   1847 C CG2 . ILE A 1 254 ? 26.360  -63.635 -0.737  1.000 31.510  0 258 ILE A CG2 1 
ATOM   1848 C CD1 . ILE A 1 254 ? 25.524  -64.580 -3.569  1.000 34.450  0 258 ILE A CD1 1 
ATOM   1849 N N   . CYS A 1 255 ? 23.389  -62.571 1.187   1.000 33.440  0 259 CYS A N   1 
ATOM   1850 C CA  . CYS A 1 255 ? 23.379  -61.612 2.285   1.000 35.540  0 259 CYS A CA  1 
ATOM   1851 C C   . CYS A 1 255 ? 22.836  -62.238 3.559   1.000 33.400  0 259 CYS A C   1 
ATOM   1852 O O   . CYS A 1 255 ? 23.300  -61.915 4.657   1.000 32.270  0 259 CYS A O   1 
ATOM   1853 C CB  . CYS A 1 255 ? 22.566  -60.373 1.899   1.000 29.180  0 259 CYS A CB  1 
ATOM   1854 S SG  . CYS A 1 255 ? 23.267  -59.485 0.477   1.000 35.670  0 259 CYS A SG  1 
ATOM   1855 N N   . ALA A 1 256 ? 21.835  -63.120 3.438   1.000 31.040  0 260 ALA A N   1 
ATOM   1856 C CA  . ALA A 1 256 ? 21.343  -63.841 4.608   1.000 31.340  0 260 ALA A CA  1 
ATOM   1857 C C   . ALA A 1 256 ? 22.458  -64.657 5.255   1.000 33.880  0 260 ALA A C   1 
ATOM   1858 O O   . ALA A 1 256 ? 22.613  -64.659 6.483   1.000 33.520  0 260 ALA A O   1 
ATOM   1859 C CB  . ALA A 1 256 ? 20.171  -64.754 4.219   1.000 32.700  0 260 ALA A CB  1 
ATOM   1860 N N   . LEU A 1 257 ? 23.230  -65.381 4.438   1.000 31.100  0 261 LEU A N   1 
ATOM   1861 C CA  . LEU A 1 257 ? 24.302  -66.207 4.984   1.000 31.630  0 261 LEU A CA  1 
ATOM   1862 C C   . LEU A 1 257 ? 25.357  -65.347 5.679   1.000 36.590  0 261 LEU A C   1 
ATOM   1863 O O   . LEU A 1 257 ? 25.861  -65.728 6.740   1.000 31.860  0 261 LEU A O   1 
ATOM   1864 C CB  . LEU A 1 257 ? 24.932  -67.058 3.888   1.000 33.470  0 261 LEU A CB  1 
ATOM   1865 C CG  . LEU A 1 257 ? 25.892  -68.158 4.369   1.000 38.370  0 261 LEU A CG  1 
ATOM   1866 C CD1 . LEU A 1 257 ? 25.135  -69.202 5.179   1.000 39.500  0 261 LEU A CD1 1 
ATOM   1867 C CD2 . LEU A 1 257 ? 26.585  -68.826 3.186   1.000 37.700  0 261 LEU A CD2 1 
ATOM   1868 N N   . GLN A 1 258 ? 25.687  -64.173 5.108   1.000 33.660  0 262 GLN A N   1 
ATOM   1869 C CA  . GLN A 1 258 ? 26.600  -63.242 5.787   1.000 32.820  0 262 GLN A CA  1 
ATOM   1870 C C   . GLN A 1 258 ? 26.075  -62.877 7.170   1.000 33.110  0 262 GLN A C   1 
ATOM   1871 O O   . GLN A 1 258 ? 26.815  -62.913 8.158   1.000 30.130  0 262 GLN A O   1 
ATOM   1872 C CB  . GLN A 1 258 ? 26.780  -61.951 4.971   1.000 29.800  0 262 GLN A CB  1 
ATOM   1873 C CG  . GLN A 1 258 ? 27.561  -62.084 3.658   1.000 33.280  0 262 GLN A CG  1 
ATOM   1874 C CD  . GLN A 1 258 ? 27.665  -60.742 2.945   1.000 31.160  0 262 GLN A CD  1 
ATOM   1875 O OE1 . GLN A 1 258 ? 26.648  -60.119 2.636   1.000 34.180  0 262 GLN A OE1 1 
ATOM   1876 N NE2 . GLN A 1 258 ? 28.904  -60.288 2.691   1.000 32.930  0 262 GLN A NE2 1 
ATOM   1877 N N   . ALA A 1 259 ? 24.794  -62.494 7.255   1.000 29.720  0 263 ALA A N   1 
ATOM   1878 C CA  . ALA A 1 259 ? 24.224  -62.129 8.551   1.000 29.970  0 263 ALA A CA  1 
ATOM   1879 C C   . ALA A 1 259 ? 24.317  -63.295 9.531   1.000 33.200  0 263 ALA A C   1 
ATOM   1880 O O   . ALA A 1 259 ? 24.723  -63.125 10.691  1.000 30.700  0 263 ALA A O   1 
ATOM   1881 C CB  . ALA A 1 259 ? 22.766  -61.673 8.379   1.000 31.000  0 263 ALA A CB  1 
ATOM   1882 N N   . ALA A 1 260 ? 23.977  -64.498 9.075   1.000 32.940  0 264 ALA A N   1 
ATOM   1883 C CA  . ALA A 1 260 ? 24.037  -65.654 9.956   1.000 32.300  0 264 ALA A CA  1 
ATOM   1884 C C   . ALA A 1 260 ? 25.455  -65.893 10.452  1.000 35.740  0 264 ALA A C   1 
ATOM   1885 O O   . ALA A 1 260 ? 25.658  -66.222 11.628  1.000 35.940  0 264 ALA A O   1 
ATOM   1886 C CB  . ALA A 1 260 ? 23.490  -66.889 9.236   1.000 35.180  0 264 ALA A CB  1 
ATOM   1887 N N   . MET A 1 261 ? 26.458  -65.681 9.585   1.000 32.760  0 265 MET A N   1 
ATOM   1888 C CA  . MET A 1 261 ? 27.842  -65.922 9.973   1.000 33.410  0 265 MET A CA  1 
ATOM   1889 C C   . MET A 1 261 ? 28.375  -64.847 10.908  1.000 34.750  0 265 MET A C   1 
ATOM   1890 O O   . MET A 1 261 ? 29.448  -65.033 11.487  1.000 36.600  0 265 MET A O   1 
ATOM   1891 C CB  . MET A 1 261 ? 28.741  -66.022 8.731   1.000 33.430  0 265 MET A CB  1 
ATOM   1892 C CG  . MET A 1 261 ? 28.391  -67.176 7.802   1.000 41.250  0 265 MET A CG  1 
ATOM   1893 S SD  . MET A 1 261 ? 28.718  -68.770 8.554   1.000 47.380  0 265 MET A SD  1 
ATOM   1894 C CE  . MET A 1 261 ? 30.491  -68.892 8.324   1.000 45.260  0 265 MET A CE  1 
ATOM   1895 N N   . GLU A 1 262 ? 27.656  -63.739 11.073  1.000 32.100  0 266 GLU A N   1 
ATOM   1896 C CA  . GLU A 1 262 ? 27.980  -62.740 12.080  1.000 36.000  0 266 GLU A CA  1 
ATOM   1897 C C   . GLU A 1 262 ? 27.203  -62.943 13.372  1.000 40.930  0 266 GLU A C   1 
ATOM   1898 O O   . GLU A 1 262 ? 27.294  -62.101 14.274  1.000 43.610  0 266 GLU A O   1 
ATOM   1899 C CB  . GLU A 1 262 ? 27.709  -61.331 11.537  1.000 36.030  0 266 GLU A CB  1 
ATOM   1900 C CG  . GLU A 1 262 ? 28.280  -61.064 10.152  1.000 42.090  0 266 GLU A CG  1 
ATOM   1901 C CD  . GLU A 1 262 ? 29.783  -60.811 10.117  1.000 48.910  0 266 GLU A CD  1 
ATOM   1902 O OE1 . GLU A 1 262 ? 30.278  -60.476 9.013   1.000 51.670  0 266 GLU A OE1 1 
ATOM   1903 O OE2 . GLU A 1 262 ? 30.472  -60.941 11.163  1.000 45.200  0 266 GLU A OE2 1 
ATOM   1904 N N   . GLY A 1 263 ? 26.427  -64.016 13.472  1.000 38.210  0 267 GLY A N   1 
ATOM   1905 C CA  . GLY A 1 263 ? 25.713  -64.328 14.688  1.000 38.770  0 267 GLY A CA  1 
ATOM   1906 C C   . GLY A 1 263 ? 24.300  -63.796 14.776  1.000 42.730  0 267 GLY A C   1 
ATOM   1907 O O   . GLY A 1 263 ? 23.700  -63.884 15.851  1.000 43.320  0 267 GLY A O   1 
ATOM   1908 N N   . TYR A 1 264 ? 23.750  -63.239 13.693  1.000 31.180  0 268 TYR A N   1 
ATOM   1909 C CA  . TYR A 1 264 ? 22.363  -62.783 13.694  1.000 28.890  0 268 TYR A CA  1 
ATOM   1910 C C   . TYR A 1 264 ? 21.439  -63.913 13.268  1.000 31.350  0 268 TYR A C   1 
ATOM   1911 O O   . TYR A 1 264 ? 21.732  -64.645 12.321  1.000 35.960  0 268 TYR A O   1 
ATOM   1912 C CB  . TYR A 1 264 ? 22.170  -61.586 12.757  1.000 30.790  0 268 TYR A CB  1 
ATOM   1913 C CG  . TYR A 1 264 ? 23.144  -60.470 13.052  1.000 29.980  0 268 TYR A CG  1 
ATOM   1914 C CD1 . TYR A 1 264 ? 23.197  -59.903 14.315  1.000 37.220  0 268 TYR A CD1 1 
ATOM   1915 C CD2 . TYR A 1 264 ? 24.042  -60.014 12.080  1.000 33.780  0 268 TYR A CD2 1 
ATOM   1916 C CE1 . TYR A 1 264 ? 24.119  -58.899 14.623  1.000 35.790  0 268 TYR A CE1 1 
ATOM   1917 C CE2 . TYR A 1 264 ? 24.959  -59.003 12.366  1.000 38.330  0 268 TYR A CE2 1 
ATOM   1918 C CZ  . TYR A 1 264 ? 24.993  -58.455 13.639  1.000 42.010  0 268 TYR A CZ  1 
ATOM   1919 O OH  . TYR A 1 264 ? 25.891  -57.454 13.939  1.000 42.580  0 268 TYR A OH  1 
ATOM   1920 N N   . ARG A 1 265 ? 20.311  -64.038 13.965  1.000 31.510  0 269 ARG A N   1 
ATOM   1921 C CA  . ARG A 1 265 ? 19.265  -64.945 13.520  1.000 33.640  0 269 ARG A CA  1 
ATOM   1922 C C   . ARG A 1 265 ? 18.565  -64.294 12.337  1.000 36.610  0 269 ARG A C   1 
ATOM   1923 O O   . ARG A 1 265 ? 18.219  -63.113 12.388  1.000 32.100  0 269 ARG A O   1 
ATOM   1924 C CB  . ARG A 1 265 ? 18.272  -65.240 14.647  1.000 33.700  0 269 ARG A CB  1 
ATOM   1925 C CG  . ARG A 1 265 ? 18.916  -65.918 15.844  1.000 38.330  0 269 ARG A CG  1 
ATOM   1926 C CD  . ARG A 1 265 ? 19.204  -67.388 15.543  1.000 45.550  0 269 ARG A CD  1 
ATOM   1927 N NE  . ARG A 1 265 ? 20.539  -67.580 14.974  1.000 51.630  0 269 ARG A NE  1 
ATOM   1928 C CZ  . ARG A 1 265 ? 20.894  -68.632 14.240  1.000 61.510  0 269 ARG A CZ  1 
ATOM   1929 N NH1 . ARG A 1 265 ? 20.007  -69.586 13.983  1.000 59.600  0 269 ARG A NH1 1 
ATOM   1930 N NH2 . ARG A 1 265 ? 22.133  -68.730 13.764  1.000 47.050  0 269 ARG A NH2 1 
ATOM   1931 N N   . VAL A 1 266 ? 18.423  -65.039 11.252  1.000 30.450  0 270 VAL A N   1 
ATOM   1932 C CA  . VAL A 1 266 ? 17.788  -64.548 10.035  1.000 35.100  0 270 VAL A CA  1 
ATOM   1933 C C   . VAL A 1 266 ? 16.360  -65.058 10.031  1.000 39.940  0 270 VAL A C   1 
ATOM   1934 O O   . VAL A 1 266 ? 16.129  -66.271 9.995   1.000 35.350  0 270 VAL A O   1 
ATOM   1935 C CB  . VAL A 1 266 ? 18.550  -65.004 8.783   1.000 31.310  0 270 VAL A CB  1 
ATOM   1936 C CG1 . VAL A 1 266 ? 17.774  -64.624 7.514   1.000 33.820  0 270 VAL A CG1 1 
ATOM   1937 C CG2 . VAL A 1 266 ? 19.983  -64.407 8.789   1.000 34.440  0 270 VAL A CG2 1 
ATOM   1938 N N   . VAL A 1 267 ? 15.404  -64.128 10.058  1.000 36.330  0 271 VAL A N   1 
ATOM   1939 C CA  . VAL A 1 267 ? 14.005  -64.400 10.370  1.000 37.150  0 271 VAL A CA  1 
ATOM   1940 C C   . VAL A 1 267 ? 13.150  -63.565 9.424   1.000 32.780  0 271 VAL A C   1 
ATOM   1941 O O   . VAL A 1 267 ? 13.652  -62.673 8.741   1.000 34.650  0 271 VAL A O   1 
ATOM   1942 C CB  . VAL A 1 267 ? 13.686  -64.050 11.844  1.000 41.530  0 271 VAL A CB  1 
ATOM   1943 C CG1 . VAL A 1 267 ? 14.560  -64.863 12.795  1.000 42.270  0 271 VAL A CG1 1 
ATOM   1944 C CG2 . VAL A 1 267 ? 13.929  -62.562 12.083  1.000 35.230  0 271 VAL A CG2 1 
ATOM   1945 N N   . THR A 1 268 ? 11.845  -63.845 9.394   1.000 33.060  0 272 THR A N   1 
ATOM   1946 C CA  . THR A 1 268 ? 10.892  -63.048 8.626   1.000 42.120  0 272 THR A CA  1 
ATOM   1947 C C   . THR A 1 268 ? 10.091  -62.159 9.569   1.000 41.050  0 272 THR A C   1 
ATOM   1948 O O   . THR A 1 268 ? 9.750   -62.569 10.682  1.000 39.560  0 272 THR A O   1 
ATOM   1949 C CB  . THR A 1 268 ? 9.908   -63.914 7.816   1.000 44.250  0 272 THR A CB  1 
ATOM   1950 O OG1 . THR A 1 268 ? 9.056   -64.640 8.709   1.000 39.590  0 272 THR A OG1 1 
ATOM   1951 C CG2 . THR A 1 268 ? 10.634  -64.893 6.882   1.000 38.740  0 272 THR A CG2 1 
ATOM   1952 N N   . LEU A 1 269 ? 9.782   -60.940 9.127   1.000 39.140  0 273 LEU A N   1 
ATOM   1953 C CA  . LEU A 1 269 ? 8.904   -60.101 9.937   1.000 38.980  0 273 LEU A CA  1 
ATOM   1954 C C   . LEU A 1 269 ? 7.534   -60.758 10.128  1.000 40.140  0 273 LEU A C   1 
ATOM   1955 O O   . LEU A 1 269 ? 6.925   -60.617 11.195  1.000 37.790  0 273 LEU A O   1 
ATOM   1956 C CB  . LEU A 1 269 ? 8.764   -58.713 9.306   1.000 36.140  0 273 LEU A CB  1 
ATOM   1957 C CG  . LEU A 1 269 ? 7.802   -57.702 9.957   1.000 41.980  0 273 LEU A CG  1 
ATOM   1958 C CD1 . LEU A 1 269 ? 8.058   -57.599 11.444  1.000 36.020  0 273 LEU A CD1 1 
ATOM   1959 C CD2 . LEU A 1 269 ? 7.987   -56.330 9.299   1.000 39.070  0 273 LEU A CD2 1 
ATOM   1960 N N   . ASP A 1 270 ? 7.050   -61.505 9.126   1.000 38.550  0 274 ASP A N   1 
ATOM   1961 C CA  . ASP A 1 270 ? 5.785   -62.235 9.283   1.000 41.070  0 274 ASP A CA  1 
ATOM   1962 C C   . ASP A 1 270 ? 5.800   -63.107 10.537  1.000 44.660  0 274 ASP A C   1 
ATOM   1963 O O   . ASP A 1 270 ? 4.792   -63.220 11.245  1.000 40.470  0 274 ASP A O   1 
ATOM   1964 C CB  . ASP A 1 270 ? 5.510   -63.116 8.059   1.000 40.320  0 274 ASP A CB  1 
ATOM   1965 C CG  . ASP A 1 270 ? 5.046   -62.329 6.843   1.000 48.490  0 274 ASP A CG  1 
ATOM   1966 O OD1 . ASP A 1 270 ? 4.794   -61.106 6.952   1.000 48.560  0 274 ASP A OD1 1 
ATOM   1967 O OD2 . ASP A 1 270 ? 4.944   -62.951 5.764   1.000 45.220  0 274 ASP A OD2 1 
ATOM   1968 N N   . ASP A 1 271 ? 6.939   -63.738 10.821  1.000 35.110  0 275 ASP A N   1 
ATOM   1969 C CA  . ASP A 1 271 ? 7.080   -64.569 12.013  1.000 40.600  0 275 ASP A CA  1 
ATOM   1970 C C   . ASP A 1 271 ? 7.238   -63.748 13.290  1.000 43.130  0 275 ASP A C   1 
ATOM   1971 O O   . ASP A 1 271 ? 6.688   -64.121 14.329  1.000 42.390  0 275 ASP A O   1 
ATOM   1972 C CB  . ASP A 1 271 ? 8.284   -65.510 11.863  1.000 37.980  0 275 ASP A CB  1 
ATOM   1973 C CG  . ASP A 1 271 ? 8.022   -66.649 10.879  1.000 45.190  0 275 ASP A CG  1 
ATOM   1974 O OD1 . ASP A 1 271 ? 6.864   -66.809 10.457  1.000 44.870  0 275 ASP A OD1 1 
ATOM   1975 O OD2 . ASP A 1 271 ? 8.965   -67.383 10.529  1.000 44.160  0 275 ASP A OD2 1 
ATOM   1976 N N   . VAL A 1 272 ? 7.984   -62.642 13.260  1.000 39.180  0 276 VAL A N   1 
ATOM   1977 C CA  . VAL A 1 272 ? 8.510   -62.096 14.511  1.000 40.740  0 276 VAL A CA  1 
ATOM   1978 C C   . VAL A 1 272 ? 7.865   -60.770 14.914  1.000 41.210  0 276 VAL A C   1 
ATOM   1979 O O   . VAL A 1 272 ? 8.280   -60.184 15.914  1.000 35.190  0 276 VAL A O   1 
ATOM   1980 C CB  . VAL A 1 272 ? 10.047  -61.958 14.474  1.000 37.970  0 276 VAL A CB  1 
ATOM   1981 C CG1 . VAL A 1 272 ? 10.710  -63.310 14.183  1.000 39.660  0 276 VAL A CG1 1 
ATOM   1982 C CG2 . VAL A 1 272 ? 10.505  -60.858 13.478  1.000 31.050  0 276 VAL A CG2 1 
ATOM   1983 N N   . ALA A 1 273 ? 6.829   -60.307 14.204  1.000 38.790  0 277 ALA A N   1 
ATOM   1984 C CA  . ALA A 1 273 ? 6.291   -58.960 14.445  1.000 40.470  0 277 ALA A CA  1 
ATOM   1985 C C   . ALA A 1 273 ? 5.993   -58.692 15.928  1.000 39.440  0 277 ALA A C   1 
ATOM   1986 O O   . ALA A 1 273 ? 6.237   -57.586 16.431  1.000 38.490  0 277 ALA A O   1 
ATOM   1987 C CB  . ALA A 1 273 ? 5.023   -58.752 13.603  1.000 35.190  0 277 ALA A CB  1 
ATOM   1988 N N   . GLU A 1 274 ? 5.494   -59.697 16.648  1.000 38.170  0 278 GLU A N   1 
ATOM   1989 C CA  . GLU A 1 274 ? 5.120   -59.538 18.051  1.000 34.780  0 278 GLU A CA  1 
ATOM   1990 C C   . GLU A 1 274 ? 6.322   -59.507 18.983  1.000 39.190  0 278 GLU A C   1 
ATOM   1991 O O   . GLU A 1 274 ? 6.173   -59.092 20.139  1.000 38.700  0 278 GLU A O   1 
ATOM   1992 C CB  . GLU A 1 274 ? 4.178   -60.672 18.488  1.000 41.130  0 278 GLU A CB  1 
ATOM   1993 C CG  . GLU A 1 274 ? 2.808   -60.608 17.872  1.000 50.530  0 278 GLU A CG  1 
ATOM   1994 C CD  . GLU A 1 274 ? 2.686   -61.465 16.630  1.000 48.560  0 278 GLU A CD  1 
ATOM   1995 O OE1 . GLU A 1 274 ? 1.549   -61.617 16.158  1.000 46.960  0 278 GLU A OE1 1 
ATOM   1996 O OE2 . GLU A 1 274 ? 3.716   -61.970 16.118  1.000 51.030  0 278 GLU A OE2 1 
ATOM   1997 N N   . GLN A 1 275 ? 7.508   -59.905 18.504  1.000 38.720  0 279 GLN A N   1 
ATOM   1998 C CA  . GLN A 1 275 ? 8.682   -60.082 19.349  1.000 46.320  0 279 GLN A CA  1 
ATOM   1999 C C   . GLN A 1 275 ? 9.640   -58.893 19.345  1.000 43.140  0 279 GLN A C   1 
ATOM   2000 O O   . GLN A 1 275 ? 10.615  -58.911 20.103  1.000 43.020  0 279 GLN A O   1 
ATOM   2001 C CB  . GLN A 1 275 ? 9.478   -61.325 18.912  1.000 47.790  0 279 GLN A CB  1 
ATOM   2002 C CG  . GLN A 1 275 ? 8.670   -62.568 18.587  1.000 52.470  0 279 GLN A CG  1 
ATOM   2003 C CD  . GLN A 1 275 ? 9.523   -63.654 17.950  1.000 58.780  0 279 GLN A CD  1 
ATOM   2004 O OE1 . GLN A 1 275 ? 10.760  -63.594 17.975  1.000 68.830  0 279 GLN A OE1 1 
ATOM   2005 N NE2 . GLN A 1 275 ? 8.870   -64.643 17.360  1.000 58.970  0 279 GLN A NE2 1 
ATOM   2006 N N   . VAL A 1 276 ? 9.414   -57.872 18.515  1.000 35.900  0 280 VAL A N   1 
ATOM   2007 C CA  . VAL A 1 276 ? 10.430  -56.842 18.284  1.000 33.870  0 280 VAL A CA  1 
ATOM   2008 C C   . VAL A 1 276 ? 10.084  -55.557 19.033  1.000 44.850  0 280 VAL A C   1 
ATOM   2009 O O   . VAL A 1 276 ? 8.914   -55.172 19.144  1.000 36.540  0 280 VAL A O   1 
ATOM   2010 C CB  . VAL A 1 276 ? 10.598  -56.571 16.777  1.000 37.430  0 280 VAL A CB  1 
ATOM   2011 C CG1 . VAL A 1 276 ? 11.174  -57.817 16.079  1.000 34.450  0 280 VAL A CG1 1 
ATOM   2012 C CG2 . VAL A 1 276 ? 9.251   -56.115 16.158  1.000 34.510  0 280 VAL A CG2 1 
ATOM   2013 N N   . ASP A 1 277 ? 11.118  -54.896 19.551  1.000 34.990  0 281 ASP A N   1 
ATOM   2014 C CA  . ASP A 1 277 ? 11.036  -53.581 20.178  1.000 41.790  0 281 ASP A CA  1 
ATOM   2015 C C   . ASP A 1 277 ? 11.316  -52.453 19.197  1.000 34.730  0 281 ASP A C   1 
ATOM   2016 O O   . ASP A 1 277 ? 10.771  -51.353 19.354  1.000 37.260  0 281 ASP A O   1 
ATOM   2017 C CB  . ASP A 1 277 ? 12.044  -53.494 21.337  1.000 38.120  0 281 ASP A CB  1 
ATOM   2018 C CG  . ASP A 1 277 ? 11.762  -54.533 22.420  1.000 38.070  0 281 ASP A CG  1 
ATOM   2019 O OD1 . ASP A 1 277 ? 10.641  -54.522 22.967  1.000 38.630  0 281 ASP A OD1 1 
ATOM   2020 O OD2 . ASP A 1 277 ? 12.634  -55.376 22.697  1.000 36.030  0 281 ASP A OD2 1 
ATOM   2021 N N   . ILE A 1 278 ? 12.167  -52.712 18.203  1.000 32.190  0 282 ILE A N   1 
ATOM   2022 C CA  . ILE A 1 278 ? 12.607  -51.740 17.210  1.000 38.920  0 282 ILE A CA  1 
ATOM   2023 C C   . ILE A 1 278 ? 12.640  -52.424 15.848  1.000 38.250  0 282 ILE A C   1 
ATOM   2024 O O   . ILE A 1 278 ? 13.145  -53.547 15.718  1.000 35.760  0 282 ILE A O   1 
ATOM   2025 C CB  . ILE A 1 278 ? 14.004  -51.166 17.549  1.000 36.430  0 282 ILE A CB  1 
ATOM   2026 C CG1 . ILE A 1 278 ? 14.025  -50.546 18.948  1.000 41.220  0 282 ILE A CG1 1 
ATOM   2027 C CG2 . ILE A 1 278 ? 14.422  -50.123 16.519  1.000 39.170  0 282 ILE A CG2 1 
ATOM   2028 C CD1 . ILE A 1 278 ? 15.432  -50.431 19.535  1.000 42.600  0 282 ILE A CD1 1 
ATOM   2029 N N   . VAL A 1 279 ? 12.117  -51.739 14.830  1.000 35.610  0 283 VAL A N   1 
ATOM   2030 C CA  . VAL A 1 279 ? 12.151  -52.200 13.444  1.000 32.710  0 283 VAL A CA  1 
ATOM   2031 C C   . VAL A 1 279 ? 12.783  -51.115 12.583  1.000 37.450  0 283 VAL A C   1 
ATOM   2032 O O   . VAL A 1 279 ? 12.350  -49.960 12.629  1.000 36.020  0 283 VAL A O   1 
ATOM   2033 C CB  . VAL A 1 279 ? 10.742  -52.543 12.923  1.000 33.390  0 283 VAL A CB  1 
ATOM   2034 C CG1 . VAL A 1 279 ? 10.802  -52.931 11.457  1.000 42.050  0 283 VAL A CG1 1 
ATOM   2035 C CG2 . VAL A 1 279 ? 10.124  -53.669 13.761  1.000 37.610  0 283 VAL A CG2 1 
ATOM   2036 N N   . VAL A 1 280 ? 13.809  -51.483 11.809  1.000 34.940  0 284 VAL A N   1 
ATOM   2037 C CA  . VAL A 1 280 ? 14.529  -50.577 10.915  1.000 35.990  0 284 VAL A CA  1 
ATOM   2038 C C   . VAL A 1 280 ? 14.441  -51.150 9.509   1.000 34.680  0 284 VAL A C   1 
ATOM   2039 O O   . VAL A 1 280 ? 15.041  -52.197 9.230   1.000 34.530  0 284 VAL A O   1 
ATOM   2040 C CB  . VAL A 1 280 ? 16.006  -50.417 11.317  1.000 30.860  0 284 VAL A CB  1 
ATOM   2041 C CG1 . VAL A 1 280 ? 16.716  -49.410 10.399  1.000 34.820  0 284 VAL A CG1 1 
ATOM   2042 C CG2 . VAL A 1 280 ? 16.143  -50.050 12.803  1.000 32.570  0 284 VAL A CG2 1 
ATOM   2043 N N   . THR A 1 281 ? 13.750  -50.457 8.603   1.000 31.810  0 285 THR A N   1 
ATOM   2044 C CA  . THR A 1 281 ? 13.731  -50.884 7.203   1.000 31.700  0 285 THR A CA  1 
ATOM   2045 C C   . THR A 1 281 ? 14.940  -50.322 6.456   1.000 36.000  0 285 THR A C   1 
ATOM   2046 O O   . THR A 1 281 ? 15.180  -49.111 6.468   1.000 35.600  0 285 THR A O   1 
ATOM   2047 C CB  . THR A 1 281 ? 12.423  -50.475 6.509   1.000 38.440  0 285 THR A CB  1 
ATOM   2048 O OG1 . THR A 1 281 ? 12.288  -49.047 6.458   1.000 33.770  0 285 THR A OG1 1 
ATOM   2049 C CG2 . THR A 1 281 ? 11.226  -51.026 7.255   1.000 36.920  0 285 THR A CG2 1 
ATOM   2050 N N   . ALA A 1 282 ? 15.687  -51.208 5.787   1.000 31.840  0 286 ALA A N   1 
ATOM   2051 C CA  . ALA A 1 282 ? 16.907  -50.862 5.060   1.000 31.820  0 286 ALA A CA  1 
ATOM   2052 C C   . ALA A 1 282 ? 16.976  -51.631 3.743   1.000 31.520  0 286 ALA A C   1 
ATOM   2053 O O   . ALA A 1 282 ? 18.048  -52.064 3.311   1.000 32.360  0 286 ALA A O   1 
ATOM   2054 C CB  . ALA A 1 282 ? 18.154  -51.138 5.908   1.000 34.060  0 286 ALA A CB  1 
ATOM   2055 N N   . THR A 1 283 ? 15.823  -51.816 3.084   1.000 31.870  0 287 THR A N   1 
ATOM   2056 C CA  . THR A 1 283 ? 15.711  -52.700 1.932   1.000 36.650  0 287 THR A CA  1 
ATOM   2057 C C   . THR A 1 283 ? 15.781  -51.996 0.587   1.000 36.040  0 287 THR A C   1 
ATOM   2058 O O   . THR A 1 283 ? 16.103  -52.644 -0.412  1.000 32.830  0 287 THR A O   1 
ATOM   2059 C CB  . THR A 1 283 ? 14.380  -53.467 1.983   1.000 31.700  0 287 THR A CB  1 
ATOM   2060 O OG1 . THR A 1 283 ? 13.308  -52.526 1.853   1.000 32.800  0 287 THR A OG1 1 
ATOM   2061 C CG2 . THR A 1 283 ? 14.218  -54.162 3.332   1.000 29.350  0 287 THR A CG2 1 
ATOM   2062 N N   . GLY A 1 284 ? 15.427  -50.713 0.510   1.000 37.210  0 288 GLY A N   1 
ATOM   2063 C CA  . GLY A 1 284 ? 15.246  -50.125 -0.804  1.000 33.920  0 288 GLY A CA  1 
ATOM   2064 C C   . GLY A 1 284 ? 14.017  -50.632 -1.523  1.000 35.250  0 288 GLY A C   1 
ATOM   2065 O O   . GLY A 1 284 ? 13.863  -50.389 -2.728  1.000 34.820  0 288 GLY A O   1 
ATOM   2066 N N   . ASN A 1 285 ? 13.129  -51.332 -0.817  1.000 32.410  0 289 ASN A N   1 
ATOM   2067 C CA  . ASN A 1 285 ? 12.018  -52.025 -1.455  1.000 34.520  0 289 ASN A CA  1 
ATOM   2068 C C   . ASN A 1 285 ? 10.702  -51.423 -0.974  1.000 36.620  0 289 ASN A C   1 
ATOM   2069 O O   . ASN A 1 285 ? 10.671  -50.379 -0.308  1.000 34.700  0 289 ASN A O   1 
ATOM   2070 C CB  . ASN A 1 285 ? 12.115  -53.537 -1.190  1.000 33.940  0 289 ASN A CB  1 
ATOM   2071 C CG  . ASN A 1 285 ? 11.581  -54.364 -2.348  1.000 34.940  0 289 ASN A CG  1 
ATOM   2072 O OD1 . ASN A 1 285 ? 10.658  -53.941 -3.035  1.000 37.560  0 289 ASN A OD1 1 
ATOM   2073 N ND2 . ASN A 1 285 ? 12.154  -55.556 -2.558  1.000 32.350  0 289 ASN A ND2 1 
ATOM   2074 N N   . TYR A 1 286 ? 9.602   -52.089 -1.328  1.000 38.260  0 290 TYR A N   1 
ATOM   2075 C CA  . TYR A 1 286 ? 8.266   -51.510 -1.266  1.000 36.730  0 290 TYR A CA  1 
ATOM   2076 C C   . TYR A 1 286 ? 7.404   -52.297 -0.285  1.000 36.060  0 290 TYR A C   1 
ATOM   2077 O O   . TYR A 1 286 ? 7.230   -53.508 -0.450  1.000 37.530  0 290 TYR A O   1 
ATOM   2078 C CB  . TYR A 1 286 ? 7.633   -51.517 -2.664  1.000 33.320  0 290 TYR A CB  1 
ATOM   2079 C CG  . TYR A 1 286 ? 6.300   -50.819 -2.757  1.000 35.750  0 290 TYR A CG  1 
ATOM   2080 C CD1 . TYR A 1 286 ? 6.232   -49.438 -2.879  1.000 35.910  0 290 TYR A CD1 1 
ATOM   2081 C CD2 . TYR A 1 286 ? 5.104   -51.541 -2.745  1.000 38.250  0 290 TYR A CD2 1 
ATOM   2082 C CE1 . TYR A 1 286 ? 5.010   -48.785 -2.966  1.000 39.850  0 290 TYR A CE1 1 
ATOM   2083 C CE2 . TYR A 1 286 ? 3.874   -50.901 -2.832  1.000 36.910  0 290 TYR A CE2 1 
ATOM   2084 C CZ  . TYR A 1 286 ? 3.835   -49.525 -2.947  1.000 37.600  0 290 TYR A CZ  1 
ATOM   2085 O OH  . TYR A 1 286 ? 2.629   -48.875 -3.035  1.000 41.160  0 290 TYR A OH  1 
ATOM   2086 N N   . HIS A 1 287 ? 6.854   -51.604 0.716   1.000 34.100  0 291 HIS A N   1 
ATOM   2087 C CA  . HIS A 1 287 ? 5.893   -52.168 1.673   1.000 36.440  0 291 HIS A CA  1 
ATOM   2088 C C   . HIS A 1 287 ? 6.421   -53.439 2.344   1.000 39.360  0 291 HIS A C   1 
ATOM   2089 O O   . HIS A 1 287 ? 5.735   -54.466 2.431   1.000 37.170  0 291 HIS A O   1 
ATOM   2090 C CB  . HIS A 1 287 ? 4.543   -52.426 1.001   1.000 38.820  0 291 HIS A CB  1 
ATOM   2091 C CG  . HIS A 1 287 ? 3.776   -51.180 0.672   1.000 41.230  0 291 HIS A CG  1 
ATOM   2092 N ND1 . HIS A 1 287 ? 2.479   -51.207 0.204   1.000 40.070  0 291 HIS A ND1 1 
ATOM   2093 C CD2 . HIS A 1 287 ? 4.123   -49.870 0.743   1.000 40.690  0 291 HIS A CD2 1 
ATOM   2094 C CE1 . HIS A 1 287 ? 2.060   -49.967 0.003   1.000 42.990  0 291 HIS A CE1 1 
ATOM   2095 N NE2 . HIS A 1 287 ? 3.038   -49.136 0.330   1.000 43.550  0 291 HIS A NE2 1 
ATOM   2096 N N   . VAL A 1 288 ? 7.653   -53.353 2.856   1.000 34.140  0 292 VAL A N   1 
ATOM   2097 C CA  . VAL A 1 288 ? 8.210   -54.446 3.650   1.000 32.370  0 292 VAL A CA  1 
ATOM   2098 C C   . VAL A 1 288 ? 7.654   -54.448 5.070   1.000 37.150  0 292 VAL A C   1 
ATOM   2099 O O   . VAL A 1 288 ? 7.760   -55.463 5.766   1.000 37.570  0 292 VAL A O   1 
ATOM   2100 C CB  . VAL A 1 288 ? 9.754   -54.392 3.665   1.000 34.860  0 292 VAL A CB  1 
ATOM   2101 C CG1 . VAL A 1 288 ? 10.299  -54.572 2.251   1.000 38.810  0 292 VAL A CG1 1 
ATOM   2102 C CG2 . VAL A 1 288 ? 10.270  -53.063 4.236   1.000 34.330  0 292 VAL A CG2 1 
ATOM   2103 N N   . VAL A 1 289 ? 7.072   -53.340 5.521   1.000 35.910  0 293 VAL A N   1 
ATOM   2104 C CA  . VAL A 1 289 ? 6.308   -53.284 6.763   1.000 38.960  0 293 VAL A CA  1 
ATOM   2105 C C   . VAL A 1 289 ? 4.874   -52.920 6.393   1.000 40.490  0 293 VAL A C   1 
ATOM   2106 O O   . VAL A 1 289 ? 4.620   -51.842 5.831   1.000 40.380  0 293 VAL A O   1 
ATOM   2107 C CB  . VAL A 1 289 ? 6.895   -52.283 7.771   1.000 38.780  0 293 VAL A CB  1 
ATOM   2108 C CG1 . VAL A 1 289 ? 6.000   -52.197 9.017   1.000 36.290  0 293 VAL A CG1 1 
ATOM   2109 C CG2 . VAL A 1 289 ? 8.322   -52.690 8.163   1.000 37.740  0 293 VAL A CG2 1 
ATOM   2110 N N   . THR A 1 290 ? 3.945   -53.828 6.680   1.000 40.840  0 294 THR A N   1 
ATOM   2111 C CA  . THR A 1 290 ? 2.551   -53.690 6.290   1.000 40.340  0 294 THR A CA  1 
ATOM   2112 C C   . THR A 1 290 ? 1.694   -53.379 7.507   1.000 39.990  0 294 THR A C   1 
ATOM   2113 O O   . THR A 1 290 ? 2.147   -53.417 8.647   1.000 39.730  0 294 THR A O   1 
ATOM   2114 C CB  . THR A 1 290 ? 2.033   -54.966 5.612   1.000 44.880  0 294 THR A CB  1 
ATOM   2115 O OG1 . THR A 1 290 ? 1.896   -56.000 6.597   1.000 44.230  0 294 THR A OG1 1 
ATOM   2116 C CG2 . THR A 1 290 ? 2.994   -55.419 4.540   1.000 45.230  0 294 THR A CG2 1 
ATOM   2117 N N   . HIS A 1 291 ? 0.420   -53.090 7.247   1.000 36.810  0 295 HIS A N   1 
ATOM   2118 C CA  . HIS A 1 291 ? -0.503  -52.797 8.337   1.000 37.670  0 295 HIS A CA  1 
ATOM   2119 C C   . HIS A 1 291 ? -0.542  -53.926 9.360   1.000 37.880  0 295 HIS A C   1 
ATOM   2120 O O   . HIS A 1 291 ? -0.512  -53.683 10.576  1.000 38.500  0 295 HIS A O   1 
ATOM   2121 C CB  . HIS A 1 291 ? -1.913  -52.565 7.797   1.000 40.010  0 295 HIS A CB  1 
ATOM   2122 C CG  . HIS A 1 291 ? -2.929  -52.434 8.881   1.000 46.570  0 295 HIS A CG  1 
ATOM   2123 N ND1 . HIS A 1 291 ? -3.661  -53.505 9.351   1.000 45.920  0 295 HIS A ND1 1 
ATOM   2124 C CD2 . HIS A 1 291 ? -3.293  -51.368 9.634   1.000 46.990  0 295 HIS A CD2 1 
ATOM   2125 C CE1 . HIS A 1 291 ? -4.451  -53.097 10.328  1.000 44.310  0 295 HIS A CE1 1 
ATOM   2126 N NE2 . HIS A 1 291 ? -4.255  -51.803 10.512  1.000 45.270  0 295 HIS A NE2 1 
ATOM   2127 N N   . ASP A 1 292 ? -0.631  -55.175 8.889   1.000 38.440  0 296 ASP A N   1 
ATOM   2128 C CA  . ASP A 1 292 ? -0.741  -56.285 9.834   1.000 42.570  0 296 ASP A CA  1 
ATOM   2129 C C   . ASP A 1 292 ? 0.499   -56.385 10.718  1.000 41.380  0 296 ASP A C   1 
ATOM   2130 O O   . ASP A 1 292 ? 0.399   -56.735 11.899  1.000 39.320  0 296 ASP A O   1 
ATOM   2131 C CB  . ASP A 1 292 ? -0.980  -57.605 9.105   1.000 38.350  0 296 ASP A CB  1 
ATOM   2132 C CG  . ASP A 1 292 ? -1.652  -58.649 10.004  1.000 45.560  0 296 ASP A CG  1 
ATOM   2133 O OD1 . ASP A 1 292 ? -2.613  -58.294 10.714  1.000 48.070  0 296 ASP A OD1 1 
ATOM   2134 O OD2 . ASP A 1 292 ? -1.210  -59.816 10.028  1.000 48.270  0 296 ASP A OD2 1 
ATOM   2135 N N   . HIS A 1 293 ? 1.681   -56.099 10.166  1.000 41.880  0 297 HIS A N   1 
ATOM   2136 C CA  . HIS A 1 293 ? 2.876   -56.111 11.003  1.000 38.780  0 297 HIS A CA  1 
ATOM   2137 C C   . HIS A 1 293 ? 2.744   -55.098 12.127  1.000 37.410  0 297 HIS A C   1 
ATOM   2138 O O   . HIS A 1 293 ? 2.992   -55.408 13.296  1.000 42.830  0 297 HIS A O   1 
ATOM   2139 C CB  . HIS A 1 293 ? 4.127   -55.806 10.171  1.000 35.040  0 297 HIS A CB  1 
ATOM   2140 C CG  . HIS A 1 293 ? 4.425   -56.828 9.116   1.000 35.030  0 297 HIS A CG  1 
ATOM   2141 N ND1 . HIS A 1 293 ? 4.957   -56.488 7.890   1.000 36.270  0 297 HIS A ND1 1 
ATOM   2142 C CD2 . HIS A 1 293 ? 4.269   -58.173 9.099   1.000 37.050  0 297 HIS A CD2 1 
ATOM   2143 C CE1 . HIS A 1 293 ? 5.121   -57.581 7.165   1.000 40.340  0 297 HIS A CE1 1 
ATOM   2144 N NE2 . HIS A 1 293 ? 4.704   -58.617 7.871   1.000 37.660  0 297 HIS A NE2 1 
ATOM   2145 N N   . MET A 1 294 ? 2.347   -53.876 11.781  1.000 38.480  0 298 MET A N   1 
ATOM   2146 C CA  . MET A 1 294 ? 2.281   -52.800 12.757  1.000 43.300  0 298 MET A CA  1 
ATOM   2147 C C   . MET A 1 294 ? 1.170   -53.044 13.767  1.000 46.510  0 298 MET A C   1 
ATOM   2148 O O   . MET A 1 294 ? 1.328   -52.742 14.955  1.000 44.590  0 298 MET A O   1 
ATOM   2149 C CB  . MET A 1 294 ? 2.099   -51.467 12.025  1.000 36.380  0 298 MET A CB  1 
ATOM   2150 C CG  . MET A 1 294 ? 3.362   -51.100 11.198  1.000 33.990  0 298 MET A CG  1 
ATOM   2151 S SD  . MET A 1 294 ? 3.203   -49.549 10.311  1.000 39.870  0 298 MET A SD  1 
ATOM   2152 C CE  . MET A 1 294 ? 2.163   -50.008 8.935   1.000 42.360  0 298 MET A CE  1 
ATOM   2153 N N   . LYS A 1 295 ? 0.053   -53.615 13.319  1.000 45.560  0 299 LYS A N   1 
ATOM   2154 C CA  . LYS A 1 295 ? -0.991  -54.007 14.263  1.000 44.710  0 299 LYS A CA  1 
ATOM   2155 C C   . LYS A 1 295 ? -0.461  -55.005 15.283  1.000 42.130  0 299 LYS A C   1 
ATOM   2156 O O   . LYS A 1 295 ? -0.774  -54.913 16.476  1.000 42.980  0 299 LYS A O   1 
ATOM   2157 C CB  . LYS A 1 295 ? -2.184  -54.600 13.522  1.000 37.110  0 299 LYS A CB  1 
ATOM   2158 C CG  . LYS A 1 295 ? -3.368  -54.893 14.461  1.000 45.210  0 299 LYS A CG  1 
ATOM   2159 C CD  . LYS A 1 295 ? -4.440  -55.676 13.773  1.000 53.080  0 299 LYS A CD  1 
ATOM   2160 C CE  . LYS A 1 295 ? -4.064  -57.143 13.626  1.000 59.690  0 299 LYS A CE  1 
ATOM   2161 N NZ  . LYS A 1 295 ? -5.243  -57.937 13.131  1.000 59.730  0 299 LYS A NZ  1 
ATOM   2162 N N   . ARG A 1 296 ? 0.360   -55.955 14.834  1.000 43.730  0 300 ARG A N   1 
ATOM   2163 C CA  . ARG A 1 296 ? 0.905   -56.997 15.693  1.000 41.120  0 300 ARG A CA  1 
ATOM   2164 C C   . ARG A 1 296 ? 2.024   -56.512 16.611  1.000 40.040  0 300 ARG A C   1 
ATOM   2165 O O   . ARG A 1 296 ? 2.363   -57.216 17.568  1.000 39.400  0 300 ARG A O   1 
ATOM   2166 C CB  . ARG A 1 296 ? 1.424   -58.151 14.831  1.000 35.320  0 300 ARG A CB  1 
ATOM   2167 C CG  . ARG A 1 296 ? 0.317   -58.947 14.153  1.000 44.150  0 300 ARG A CG  1 
ATOM   2168 C CD  . ARG A 1 296 ? 0.884   -59.866 13.095  1.000 40.310  0 300 ARG A CD  1 
ATOM   2169 N NE  . ARG A 1 296 ? 1.826   -60.822 13.681  1.000 40.240  0 300 ARG A NE  1 
ATOM   2170 C CZ  . ARG A 1 296 ? 2.670   -61.560 12.968  1.000 43.090  0 300 ARG A CZ  1 
ATOM   2171 N NH1 . ARG A 1 296 ? 2.696   -61.442 11.645  1.000 41.990  0 300 ARG A NH1 1 
ATOM   2172 N NH2 . ARG A 1 296 ? 3.480   -62.421 13.570  1.000 43.420  0 300 ARG A NH2 1 
ATOM   2173 N N   . MET A 1 297 ? 2.596   -55.342 16.354  1.000 39.860  0 301 MET A N   1 
ATOM   2174 C CA  . MET A 1 297 ? 3.751   -54.896 17.123  1.000 37.830  0 301 MET A CA  1 
ATOM   2175 C C   . MET A 1 297 ? 3.341   -54.517 18.543  1.000 45.810  0 301 MET A C   1 
ATOM   2176 O O   . MET A 1 297 ? 2.196   -54.135 18.807  1.000 40.760  0 301 MET A O   1 
ATOM   2177 C CB  . MET A 1 297 ? 4.432   -53.731 16.412  1.000 36.470  0 301 MET A CB  1 
ATOM   2178 C CG  . MET A 1 297 ? 5.377   -54.202 15.301  1.000 43.060  0 301 MET A CG  1 
ATOM   2179 S SD  . MET A 1 297 ? 5.964   -52.906 14.196  1.000 44.340  0 301 MET A SD  1 
ATOM   2180 C CE  . MET A 1 297 ? 5.703   -51.445 15.186  1.000 60.970  0 301 MET A CE  1 
ATOM   2181 N N   . ARG A 1 298 ? 4.279   -54.677 19.474  1.000 38.570  0 302 ARG A N   1 
ATOM   2182 C CA  . ARG A 1 298 ? 3.985   -54.411 20.871  1.000 38.530  0 302 ARG A CA  1 
ATOM   2183 C C   . ARG A 1 298 ? 3.768   -52.914 21.106  1.000 38.690  0 302 ARG A C   1 
ATOM   2184 O O   . ARG A 1 298 ? 4.171   -52.056 20.308  1.000 37.530  0 302 ARG A O   1 
ATOM   2185 C CB  . ARG A 1 298 ? 5.103   -54.951 21.775  1.000 44.190  0 302 ARG A CB  1 
ATOM   2186 C CG  . ARG A 1 298 ? 6.500   -54.351 21.532  1.000 44.450  0 302 ARG A CG  1 
ATOM   2187 C CD  . ARG A 1 298 ? 7.567   -55.041 22.397  1.000 50.970  0 302 ARG A CD  1 
ATOM   2188 N NE  . ARG A 1 298 ? 7.390   -56.499 22.452  1.000 61.330  0 302 ARG A NE  1 
ATOM   2189 C CZ  . ARG A 1 298 ? 8.334   -57.392 22.773  1.000 67.170  0 302 ARG A CZ  1 
ATOM   2190 N NH1 . ARG A 1 298 ? 9.588   -57.024 23.081  1.000 47.020  0 302 ARG A NH1 1 
ATOM   2191 N NH2 . ARG A 1 298 ? 8.016   -58.681 22.786  1.000 61.930  0 302 ARG A NH2 1 
ATOM   2192 N N   . ASN A 1 299 ? 3.082   -52.612 22.208  1.000 37.800  0 303 ASN A N   1 
ATOM   2193 C CA  . ASN A 1 299 ? 2.882   -51.231 22.640  1.000 43.770  0 303 ASN A CA  1 
ATOM   2194 C C   . ASN A 1 299 ? 4.223   -50.514 22.774  1.000 38.780  0 303 ASN A C   1 
ATOM   2195 O O   . ASN A 1 299 ? 5.175   -51.062 23.330  1.000 38.210  0 303 ASN A O   1 
ATOM   2196 C CB  . ASN A 1 299 ? 2.127   -51.229 23.976  1.000 45.350  0 303 ASN A CB  1 
ATOM   2197 C CG  . ASN A 1 299 ? 1.746   -49.840 24.438  1.000 42.710  0 303 ASN A CG  1 
ATOM   2198 O OD1 . ASN A 1 299 ? 1.160   -49.058 23.688  1.000 44.210  0 303 ASN A OD1 1 
ATOM   2199 N ND2 . ASN A 1 299 ? 2.062   -49.530 25.690  1.000 43.950  0 303 ASN A ND2 1 
ATOM   2200 N N   . GLN A 1 300 ? 4.292   -49.292 22.236  1.000 37.650  0 304 GLN A N   1 
ATOM   2201 C CA  . GLN A 1 300 ? 5.480   -48.429 22.215  1.000 41.780  0 304 GLN A CA  1 
ATOM   2202 C C   . GLN A 1 300 ? 6.617   -48.976 21.354  1.000 41.040  0 304 GLN A C   1 
ATOM   2203 O O   . GLN A 1 300 ? 7.750   -48.494 21.451  1.000 38.870  0 304 GLN A O   1 
ATOM   2204 C CB  . GLN A 1 300 ? 6.005   -48.125 23.629  1.000 41.870  0 304 GLN A CB  1 
ATOM   2205 C CG  . GLN A 1 300 ? 4.961   -47.492 24.576  1.000 42.200  0 304 GLN A CG  1 
ATOM   2206 C CD  . GLN A 1 300 ? 4.550   -46.085 24.173  1.000 47.810  0 304 GLN A CD  1 
ATOM   2207 O OE1 . GLN A 1 300 ? 5.183   -45.456 23.330  1.000 42.680  0 304 GLN A OE1 1 
ATOM   2208 N NE2 . GLN A 1 300 ? 3.463   -45.596 24.761  1.000 48.280  0 304 GLN A NE2 1 
ATOM   2209 N N   . ALA A 1 301 ? 6.358   -49.964 20.503  1.000 38.070  0 305 ALA A N   1 
ATOM   2210 C CA  . ALA A 1 301 ? 7.384   -50.391 19.558  1.000 40.850  0 305 ALA A CA  1 
ATOM   2211 C C   . ALA A 1 301 ? 7.801   -49.217 18.672  1.000 37.770  0 305 ALA A C   1 
ATOM   2212 O O   . ALA A 1 301 ? 6.999   -48.332 18.356  1.000 38.720  0 305 ALA A O   1 
ATOM   2213 C CB  . ALA A 1 301 ? 6.874   -51.547 18.702  1.000 36.880  0 305 ALA A CB  1 
ATOM   2214 N N   . ILE A 1 302 ? 9.076   -49.198 18.289  1.000 38.170  0 306 ILE A N   1 
ATOM   2215 C CA  . ILE A 1 302 ? 9.641   -48.103 17.509  1.000 33.720  0 306 ILE A CA  1 
ATOM   2216 C C   . ILE A 1 302 ? 9.841   -48.577 16.080  1.000 34.770  0 306 ILE A C   1 
ATOM   2217 O O   . ILE A 1 302 ? 10.485  -49.608 15.839  1.000 37.180  0 306 ILE A O   1 
ATOM   2218 C CB  . ILE A 1 302 ? 10.962  -47.601 18.111  1.000 35.230  0 306 ILE A CB  1 
ATOM   2219 C CG1 . ILE A 1 302 ? 10.686  -46.886 19.436  1.000 34.120  0 306 ILE A CG1 1 
ATOM   2220 C CG2 . ILE A 1 302 ? 11.669  -46.676 17.128  1.000 34.300  0 306 ILE A CG2 1 
ATOM   2221 C CD1 . ILE A 1 302 ? 11.990  -46.562 20.197  1.000 35.420  0 306 ILE A CD1 1 
ATOM   2222 N N   . LEU A 1 303 ? 9.309   -47.809 15.136  1.000 33.900  0 307 LEU A N   1 
ATOM   2223 C CA  . LEU A 1 303 ? 9.372   -48.133 13.719  1.000 33.590  0 307 LEU A CA  1 
ATOM   2224 C C   . LEU A 1 303 ? 10.041  -46.990 12.975  1.000 35.990  0 307 LEU A C   1 
ATOM   2225 O O   . LEU A 1 303 ? 9.621   -45.834 13.105  1.000 37.630  0 307 LEU A O   1 
ATOM   2226 C CB  . LEU A 1 303 ? 7.967   -48.383 13.160  1.000 33.830  0 307 LEU A CB  1 
ATOM   2227 C CG  . LEU A 1 303 ? 7.898   -48.531 11.645  1.000 36.030  0 307 LEU A CG  1 
ATOM   2228 C CD1 . LEU A 1 303 ? 8.748   -49.713 11.188  1.000 38.540  0 307 LEU A CD1 1 
ATOM   2229 C CD2 . LEU A 1 303 ? 6.442   -48.703 11.220  1.000 39.720  0 307 LEU A CD2 1 
ATOM   2230 N N   . CYS A 1 304 ? 11.089  -47.305 12.204  1.000 33.440  0 308 CYS A N   1 
ATOM   2231 C CA  . CYS A 1 304 ? 11.730  -46.277 11.398  1.000 35.560  0 308 CYS A CA  1 
ATOM   2232 C C   . CYS A 1 304 ? 12.241  -46.873 10.093  1.000 36.130  0 308 CYS A C   1 
ATOM   2233 O O   . CYS A 1 304 ? 12.360  -48.091 9.935   1.000 35.840  0 308 CYS A O   1 
ATOM   2234 C CB  . CYS A 1 304 ? 12.864  -45.587 12.168  1.000 36.390  0 308 CYS A CB  1 
ATOM   2235 S SG  . CYS A 1 304 ? 14.272  -46.637 12.533  1.000 37.030  0 308 CYS A SG  1 
ATOM   2236 N N   . ASN A 1 305 ? 12.556  -45.981 9.160   1.000 37.190  0 309 ASN A N   1 
ATOM   2237 C CA  . ASN A 1 305 ? 13.075  -46.328 7.848   1.000 36.140  0 309 ASN A CA  1 
ATOM   2238 C C   . ASN A 1 305 ? 14.392  -45.592 7.627   1.000 40.750  0 309 ASN A C   1 
ATOM   2239 O O   . ASN A 1 305 ? 14.464  -44.377 7.831   1.000 35.420  0 309 ASN A O   1 
ATOM   2240 C CB  . ASN A 1 305 ? 12.062  -45.955 6.757   1.000 32.910  0 309 ASN A CB  1 
ATOM   2241 C CG  . ASN A 1 305 ? 12.677  -45.936 5.372   1.000 33.790  0 309 ASN A CG  1 
ATOM   2242 O OD1 . ASN A 1 305 ? 13.264  -46.926 4.939   1.000 35.070  0 309 ASN A OD1 1 
ATOM   2243 N ND2 . ASN A 1 305 ? 12.572  -44.791 4.675   1.000 37.050  0 309 ASN A ND2 1 
ATOM   2244 N N   . ILE A 1 306 ? 15.431  -46.322 7.220   1.000 31.340  0 310 ILE A N   1 
ATOM   2245 C CA  . ILE A 1 306 ? 16.705  -45.720 6.839   1.000 30.490  0 310 ILE A CA  1 
ATOM   2246 C C   . ILE A 1 306 ? 17.005  -45.909 5.353   1.000 29.670  0 310 ILE A C   1 
ATOM   2247 O O   . ILE A 1 306 ? 18.078  -45.488 4.875   1.000 36.670  0 310 ILE A O   1 
ATOM   2248 C CB  . ILE A 1 306 ? 17.849  -46.250 7.722   1.000 34.730  0 310 ILE A CB  1 
ATOM   2249 C CG1 . ILE A 1 306 ? 19.072  -45.301 7.687   1.000 36.910  0 310 ILE A CG1 1 
ATOM   2250 C CG2 . ILE A 1 306 ? 18.189  -47.715 7.378   1.000 32.750  0 310 ILE A CG2 1 
ATOM   2251 C CD1 . ILE A 1 306 ? 19.980  -45.444 8.879   1.000 35.610  0 310 ILE A CD1 1 
ATOM   2252 N N   . GLY A 1 307 ? 16.078  -46.519 4.596   1.000 33.930  0 311 GLY A N   1 
ATOM   2253 C CA  . GLY A 1 307 ? 16.206  -46.586 3.155   1.000 31.690  0 311 GLY A CA  1 
ATOM   2254 C C   . GLY A 1 307 ? 15.699  -45.298 2.530   1.000 31.590  0 311 GLY A C   1 
ATOM   2255 O O   . GLY A 1 307 ? 15.162  -44.443 3.224   1.000 35.760  0 311 GLY A O   1 
ATOM   2256 N N   . HIS A 1 308 ? 15.882  -45.164 1.211   1.000 34.540  0 312 HIS A N   1 
ATOM   2257 C CA  . HIS A 1 308 ? 15.757  -43.837 0.608   1.000 32.040  0 312 HIS A CA  1 
ATOM   2258 C C   . HIS A 1 308 ? 14.325  -43.303 0.650   1.000 39.700  0 312 HIS A C   1 
ATOM   2259 O O   . HIS A 1 308 ? 14.120  -42.103 0.891   1.000 35.740  0 312 HIS A O   1 
ATOM   2260 C CB  . HIS A 1 308 ? 16.245  -43.831 -0.837  1.000 37.260  0 312 HIS A CB  1 
ATOM   2261 C CG  . HIS A 1 308 ? 16.250  -42.462 -1.430  1.000 40.630  0 312 HIS A CG  1 
ATOM   2262 N ND1 . HIS A 1 308 ? 17.250  -41.550 -1.170  1.000 39.910  0 312 HIS A ND1 1 
ATOM   2263 C CD2 . HIS A 1 308 ? 15.349  -41.822 -2.218  1.000 40.050  0 312 HIS A CD2 1 
ATOM   2264 C CE1 . HIS A 1 308 ? 16.979  -40.415 -1.793  1.000 44.210  0 312 HIS A CE1 1 
ATOM   2265 N NE2 . HIS A 1 308 ? 15.830  -40.552 -2.432  1.000 39.650  0 312 HIS A NE2 1 
ATOM   2266 N N   . PHE A 1 309 ? 13.329  -44.151 0.379   1.000 37.300  0 313 PHE A N   1 
ATOM   2267 C CA  . PHE A 1 309 ? 11.939  -43.708 0.264   1.000 36.640  0 313 PHE A CA  1 
ATOM   2268 C C   . PHE A 1 309 ? 11.079  -44.254 1.397   1.000 36.350  0 313 PHE A C   1 
ATOM   2269 O O   . PHE A 1 309 ? 11.246  -45.399 1.836   1.000 36.760  0 313 PHE A O   1 
ATOM   2270 C CB  . PHE A 1 309 ? 11.327  -44.135 -1.073  1.000 34.190  0 313 PHE A CB  1 
ATOM   2271 C CG  . PHE A 1 309 ? 11.797  -43.328 -2.250  1.000 35.480  0 313 PHE A CG  1 
ATOM   2272 C CD1 . PHE A 1 309 ? 11.703  -41.942 -2.240  1.000 42.370  0 313 PHE A CD1 1 
ATOM   2273 C CD2 . PHE A 1 309 ? 12.297  -43.956 -3.383  1.000 35.480  0 313 PHE A CD2 1 
ATOM   2274 C CE1 . PHE A 1 309 ? 12.109  -41.192 -3.341  1.000 38.130  0 313 PHE A CE1 1 
ATOM   2275 C CE2 . PHE A 1 309 ? 12.694  -43.217 -4.494  1.000 35.920  0 313 PHE A CE2 1 
ATOM   2276 C CZ  . PHE A 1 309 ? 12.601  -41.825 -4.471  1.000 36.420  0 313 PHE A CZ  1 
ATOM   2277 N N   . ASP A 1 310 ? 10.125  -43.433 1.842   1.000 37.280  0 314 ASP A N   1 
ATOM   2278 C CA  . ASP A 1 310 ? 9.216   -43.828 2.905   1.000 39.150  0 314 ASP A CA  1 
ATOM   2279 C C   . ASP A 1 310 ? 8.287   -44.964 2.492   1.000 42.040  0 314 ASP A C   1 
ATOM   2280 O O   . ASP A 1 310 ? 7.588   -45.510 3.351   1.000 42.620  0 314 ASP A O   1 
ATOM   2281 C CB  . ASP A 1 310 ? 8.382   -42.619 3.337   1.000 40.830  0 314 ASP A CB  1 
ATOM   2282 C CG  . ASP A 1 310 ? 7.552   -42.064 2.201   1.000 42.620  0 314 ASP A CG  1 
ATOM   2283 O OD1 . ASP A 1 310 ? 8.060   -41.218 1.430   1.000 38.450  0 314 ASP A OD1 1 
ATOM   2284 O OD2 . ASP A 1 310 ? 6.389   -42.489 2.064   1.000 42.000  0 314 ASP A OD2 1 
ATOM   2285 N N   . SER A 1 311 ? 8.265   -45.335 1.208   1.000 35.310  0 315 SER A N   1 
ATOM   2286 C CA  . SER A 1 311 ? 7.409   -46.433 0.773   1.000 36.800  0 315 SER A CA  1 
ATOM   2287 C C   . SER A 1 311 ? 7.868   -47.804 1.273   1.000 34.900  0 315 SER A C   1 
ATOM   2288 O O   . SER A 1 311 ? 7.152   -48.786 1.025   1.000 34.830  0 315 SER A O   1 
ATOM   2289 C CB  . SER A 1 311 ? 7.296   -46.439 -0.756  1.000 42.560  0 315 SER A CB  1 
ATOM   2290 O OG  . SER A 1 311 ? 8.567   -46.362 -1.370  1.000 47.000  0 315 SER A OG  1 
ATOM   2291 N N   . GLU A 1 312 ? 9.007   -47.911 1.976   1.000 36.410  0 316 GLU A N   1 
ATOM   2292 C CA  . GLU A 1 312 ? 9.330   -49.174 2.648   1.000 37.040  0 316 GLU A CA  1 
ATOM   2293 C C   . GLU A 1 312 ? 8.238   -49.557 3.643   1.000 34.060  0 316 GLU A C   1 
ATOM   2294 O O   . GLU A 1 312 ? 8.016   -50.747 3.906   1.000 34.710  0 316 GLU A O   1 
ATOM   2295 C CB  . GLU A 1 312 ? 10.689  -49.086 3.356   1.000 31.960  0 316 GLU A CB  1 
ATOM   2296 C CG  . GLU A 1 312 ? 11.835  -48.657 2.406   1.000 31.620  0 316 GLU A CG  1 
ATOM   2297 C CD  . GLU A 1 312 ? 13.163  -49.367 2.658   1.000 35.290  0 316 GLU A CD  1 
ATOM   2298 O OE1 . GLU A 1 312 ? 13.216  -50.389 3.392   1.000 33.590  0 316 GLU A OE1 1 
ATOM   2299 O OE2 . GLU A 1 312 ? 14.165  -48.880 2.097   1.000 33.900  0 316 GLU A OE2 1 
ATOM   2300 N N   . ILE A 1 313 ? 7.534   -48.569 4.187   1.000 36.630  0 317 ILE A N   1 
ATOM   2301 C CA  . ILE A 1 313 ? 6.466   -48.793 5.157   1.000 33.840  0 317 ILE A CA  1 
ATOM   2302 C C   . ILE A 1 313 ? 5.163   -48.329 4.541   1.000 36.710  0 317 ILE A C   1 
ATOM   2303 O O   . ILE A 1 313 ? 5.118   -47.250 3.937   1.000 36.000  0 317 ILE A O   1 
ATOM   2304 C CB  . ILE A 1 313 ? 6.737   -48.034 6.477   1.000 38.220  0 317 ILE A CB  1 
ATOM   2305 C CG1 . ILE A 1 313 ? 8.064   -48.475 7.106   1.000 38.720  0 317 ILE A CG1 1 
ATOM   2306 C CG2 . ILE A 1 313 ? 5.608   -48.254 7.462   1.000 37.660  0 317 ILE A CG2 1 
ATOM   2307 C CD1 . ILE A 1 313 ? 8.593   -47.479 8.107   1.000 40.610  0 317 ILE A CD1 1 
ATOM   2308 N N   . ASP A 1 314 ? 4.089   -49.125 4.695   1.000 35.830  0 318 ASP A N   1 
ATOM   2309 C CA  . ASP A 1 314 ? 2.794   -48.708 4.164   1.000 40.080  0 318 ASP A CA  1 
ATOM   2310 C C   . ASP A 1 314 ? 2.184   -47.729 5.169   1.000 47.210  0 318 ASP A C   1 
ATOM   2311 O O   . ASP A 1 314 ? 1.276   -48.056 5.944   1.000 45.950  0 318 ASP A O   1 
ATOM   2312 C CB  . ASP A 1 314 ? 1.880   -49.906 3.896   1.000 39.490  0 318 ASP A CB  1 
ATOM   2313 C CG  . ASP A 1 314 ? 0.568   -49.505 3.228   1.000 42.220  0 318 ASP A CG  1 
ATOM   2314 O OD1 . ASP A 1 314 ? 0.581   -48.526 2.445   1.000 46.960  0 318 ASP A OD1 1 
ATOM   2315 O OD2 . ASP A 1 314 ? -0.452  -50.185 3.451   1.000 44.060  0 318 ASP A OD2 1 
ATOM   2316 N N   . ILE A 1 315 ? 2.710   -46.500 5.148   1.000 41.350  0 319 ILE A N   1 
ATOM   2317 C CA  . ILE A 1 315 ? 2.234   -45.443 6.035   1.000 42.200  0 319 ILE A CA  1 
ATOM   2318 C C   . ILE A 1 315 ? 0.766   -45.155 5.771   1.000 40.920  0 319 ILE A C   1 
ATOM   2319 O O   . ILE A 1 315 ? 0.018   -44.821 6.700   1.000 43.450  0 319 ILE A O   1 
ATOM   2320 C CB  . ILE A 1 315 ? 3.107   -44.179 5.857   1.000 36.710  0 319 ILE A CB  1 
ATOM   2321 C CG1 . ILE A 1 315 ? 4.559   -44.464 6.267   1.000 37.520  0 319 ILE A CG1 1 
ATOM   2322 C CG2 . ILE A 1 315 ? 2.518   -42.988 6.608   1.000 41.450  0 319 ILE A CG2 1 
ATOM   2323 C CD1 . ILE A 1 315 ? 4.776   -44.639 7.777   1.000 45.150  0 319 ILE A CD1 1 
ATOM   2324 N N   . GLN A 1 316 ? 0.329   -45.301 4.510   1.000 39.670  0 320 GLN A N   1 
ATOM   2325 C CA  . GLN A 1 316 ? -1.063  -45.074 4.124   1.000 42.420  0 320 GLN A CA  1 
ATOM   2326 C C   . GLN A 1 316 ? -2.044  -45.892 4.960   1.000 46.470  0 320 GLN A C   1 
ATOM   2327 O O   . GLN A 1 316 ? -3.172  -45.458 5.193   1.000 43.800  0 320 GLN A O   1 
ATOM   2328 C CB  . GLN A 1 316 ? -1.237  -45.394 2.631   1.000 54.050  0 320 GLN A CB  1 
ATOM   2329 C CG  . GLN A 1 316 ? -2.671  -45.532 2.153   1.000 74.910  0 320 GLN A CG  1 
ATOM   2330 C CD  . GLN A 1 316 ? -2.765  -45.797 0.658   1.000 82.340  0 320 GLN A CD  1 
ATOM   2331 O OE1 . GLN A 1 316 ? -1.807  -46.246 0.020   1.000 88.490  0 320 GLN A OE1 1 
ATOM   2332 N NE2 . GLN A 1 316 ? -3.922  -45.510 0.093   1.000 81.410  0 320 GLN A NE2 1 
ATOM   2333 N N   . SER A 1 317 ? -1.649  -47.073 5.419   1.000 41.370  0 321 SER A N   1 
ATOM   2334 C CA  . SER A 1 317 ? -2.564  -47.891 6.209   1.000 49.550  0 321 SER A CA  1 
ATOM   2335 C C   . SER A 1 317 ? -2.862  -47.295 7.581   1.000 52.170  0 321 SER A C   1 
ATOM   2336 O O   . SER A 1 317 ? -3.771  -47.779 8.263   1.000 43.940  0 321 SER A O   1 
ATOM   2337 C CB  . SER A 1 317 ? -1.993  -49.305 6.365   1.000 44.670  0 321 SER A CB  1 
ATOM   2338 O OG  . SER A 1 317 ? -0.851  -49.302 7.204   1.000 40.530  0 321 SER A OG  1 
ATOM   2339 N N   . LEU A 1 318 ? -2.141  -46.259 7.999   1.000 46.750  0 322 LEU A N   1 
ATOM   2340 C CA  . LEU A 1 318 ? -2.329  -45.660 9.312   1.000 46.510  0 322 LEU A CA  1 
ATOM   2341 C C   . LEU A 1 318 ? -3.160  -44.380 9.272   1.000 46.270  0 322 LEU A C   1 
ATOM   2342 O O   . LEU A 1 318 ? -3.369  -43.762 10.323  1.000 47.060  0 322 LEU A O   1 
ATOM   2343 C CB  . LEU A 1 318 ? -0.963  -45.385 9.946   1.000 44.660  0 322 LEU A CB  1 
ATOM   2344 C CG  . LEU A 1 318 ? -0.019  -46.590 9.903   1.000 46.460  0 322 LEU A CG  1 
ATOM   2345 C CD1 . LEU A 1 318 ? 1.375   -46.208 10.338  1.000 44.060  0 322 LEU A CD1 1 
ATOM   2346 C CD2 . LEU A 1 318 ? -0.569  -47.718 10.766  1.000 52.260  0 322 LEU A CD2 1 
ATOM   2347 N N   . LYS A 1 319 ? -3.674  -44.011 8.091   1.000 45.490  0 323 LYS A N   1 
ATOM   2348 C CA  . LYS A 1 319 ? -4.347  -42.730 7.849   1.000 56.470  0 323 LYS A CA  1 
ATOM   2349 C C   . LYS A 1 319 ? -5.524  -42.474 8.785   1.000 57.640  0 323 LYS A C   1 
ATOM   2350 O O   . LYS A 1 319 ? -5.850  -41.313 9.071   1.000 54.520  0 323 LYS A O   1 
ATOM   2351 C CB  . LYS A 1 319 ? -4.869  -42.675 6.401   1.000 70.280  0 323 LYS A CB  1 
ATOM   2352 C CG  . LYS A 1 319 ? -6.120  -43.588 6.060   1.000 81.890  0 323 LYS A CG  1 
ATOM   2353 C CD  . LYS A 1 319 ? -5.734  -45.063 6.178   1.000 84.840  0 323 LYS A CD  1 
ATOM   2354 C CE  . LYS A 1 319 ? -6.782  -46.082 5.815   1.000 84.870  0 323 LYS A CE  1 
ATOM   2355 N NZ  . LYS A 1 319 ? -6.173  -47.394 6.207   1.000 76.720  0 323 LYS A NZ  1 
ATOM   2356 N N   . GLN A 1 320 ? -6.224  -43.520 9.203   1.000 47.840  0 324 GLN A N   1 
ATOM   2357 C CA  . GLN A 1 320 ? -7.470  -43.339 9.928   1.000 49.900  0 324 GLN A CA  1 
ATOM   2358 C C   . GLN A 1 320 ? -7.291  -43.414 11.433  1.000 57.910  0 324 GLN A C   1 
ATOM   2359 O O   . GLN A 1 320 ? -8.246  -43.147 12.174  1.000 51.410  0 324 GLN A O   1 
ATOM   2360 C CB  . GLN A 1 320 ? -8.496  -44.376 9.467   1.000 46.130  0 324 GLN A CB  1 
ATOM   2361 C CG  . GLN A 1 320 ? -9.091  -44.052 8.112   1.000 54.310  0 324 GLN A CG  1 
ATOM   2362 C CD  . GLN A 1 320 ? -10.123 -45.075 7.683   1.000 70.040  0 324 GLN A CD  1 
ATOM   2363 O OE1 . GLN A 1 320 ? -10.785 -44.915 6.655   1.000 79.550  0 324 GLN A OE1 1 
ATOM   2364 N NE2 . GLN A 1 320 ? -10.271 -46.133 8.474   1.000 69.180  0 324 GLN A NE2 1 
ATOM   2365 N N   . TYR A 1 321 ? -6.094  -43.759 11.895  1.000 49.650  0 325 TYR A N   1 
ATOM   2366 C CA  . TYR A 1 321 ? -5.785  -43.751 13.311  1.000 53.910  0 325 TYR A CA  1 
ATOM   2367 C C   . TYR A 1 321 ? -5.392  -42.345 13.740  1.000 56.660  0 325 TYR A C   1 
ATOM   2368 O O   . TYR A 1 321 ? -4.947  -41.525 12.933  1.000 54.850  0 325 TYR A O   1 
ATOM   2369 C CB  . TYR A 1 321 ? -4.653  -44.736 13.617  1.000 51.030  0 325 TYR A CB  1 
ATOM   2370 C CG  . TYR A 1 321 ? -4.947  -46.157 13.181  1.000 48.820  0 325 TYR A CG  1 
ATOM   2371 C CD1 . TYR A 1 321 ? -6.212  -46.703 13.350  1.000 54.450  0 325 TYR A CD1 1 
ATOM   2372 C CD2 . TYR A 1 321 ? -3.952  -46.957 12.606  1.000 51.080  0 325 TYR A CD2 1 
ATOM   2373 C CE1 . TYR A 1 321 ? -6.495  -47.999 12.957  1.000 56.290  0 325 TYR A CE1 1 
ATOM   2374 C CE2 . TYR A 1 321 ? -4.224  -48.264 12.208  1.000 44.040  0 325 TYR A CE2 1 
ATOM   2375 C CZ  . TYR A 1 321 ? -5.501  -48.775 12.392  1.000 53.740  0 325 TYR A CZ  1 
ATOM   2376 O OH  . TYR A 1 321 ? -5.800  -50.057 12.005  1.000 51.590  0 325 TYR A OH  1 
ATOM   2377 N N   . GLN A 1 322 ? -5.566  -42.065 15.026  1.000 54.090  0 326 GLN A N   1 
ATOM   2378 C CA  . GLN A 1 322 ? -5.085  -40.799 15.553  1.000 54.130  0 326 GLN A CA  1 
ATOM   2379 C C   . GLN A 1 322 ? -3.566  -40.781 15.535  1.000 54.510  0 326 GLN A C   1 
ATOM   2380 O O   . GLN A 1 322 ? -2.913  -41.714 16.019  1.000 50.450  0 326 GLN A O   1 
ATOM   2381 C CB  . GLN A 1 322 ? -5.585  -40.560 16.974  1.000 61.210  0 326 GLN A CB  1 
ATOM   2382 C CG  . GLN A 1 322 ? -5.159  -39.203 17.531  1.000 59.820  0 326 GLN A CG  1 
ATOM   2383 C CD  . GLN A 1 322 ? -5.637  -38.970 18.947  1.000 60.530  0 326 GLN A CD  1 
ATOM   2384 O OE1 . GLN A 1 322 ? -6.541  -39.654 19.430  1.000 55.100  0 326 GLN A OE1 1 
ATOM   2385 N NE2 . GLN A 1 322 ? -5.011  -38.016 19.633  1.000 62.630  0 326 GLN A NE2 1 
ATOM   2386 N N   . TRP A 1 323 ? -3.003  -39.726 14.962  1.000 44.210  0 327 TRP A N   1 
ATOM   2387 C CA  . TRP A 1 323 ? -1.583  -39.452 15.088  1.000 47.800  0 327 TRP A CA  1 
ATOM   2388 C C   . TRP A 1 323 ? -1.440  -38.382 16.156  1.000 47.260  0 327 TRP A C   1 
ATOM   2389 O O   . TRP A 1 323 ? -1.992  -37.284 16.016  1.000 54.340  0 327 TRP A O   1 
ATOM   2390 C CB  . TRP A 1 323 ? -0.973  -38.994 13.768  1.000 50.440  0 327 TRP A CB  1 
ATOM   2391 C CG  . TRP A 1 323 ? -0.762  -40.090 12.775  1.000 49.370  0 327 TRP A CG  1 
ATOM   2392 C CD1 . TRP A 1 323 ? -1.711  -40.928 12.252  1.000 48.470  0 327 TRP A CD1 1 
ATOM   2393 C CD2 . TRP A 1 323 ? 0.479   -40.454 12.161  1.000 49.970  0 327 TRP A CD2 1 
ATOM   2394 N NE1 . TRP A 1 323 ? -1.128  -41.797 11.353  1.000 45.830  0 327 TRP A NE1 1 
ATOM   2395 C CE2 . TRP A 1 323 ? 0.213   -41.523 11.280  1.000 49.090  0 327 TRP A CE2 1 
ATOM   2396 C CE3 . TRP A 1 323 ? 1.793   -39.980 12.272  1.000 49.030  0 327 TRP A CE3 1 
ATOM   2397 C CZ2 . TRP A 1 323 ? 1.211   -42.125 10.516  1.000 45.470  0 327 TRP A CZ2 1 
ATOM   2398 C CZ3 . TRP A 1 323 ? 2.779   -40.576 11.514  1.000 51.070  0 327 TRP A CZ3 1 
ATOM   2399 C CH2 . TRP A 1 323 ? 2.485   -41.635 10.643  1.000 51.520  0 327 TRP A CH2 1 
ATOM   2400 N N   . GLU A 1 324 ? -0.765  -38.725 17.239  1.000 46.020  0 328 GLU A N   1 
ATOM   2401 C CA  . GLU A 1 324 ? -0.479  -37.796 18.322  1.000 44.050  0 328 GLU A CA  1 
ATOM   2402 C C   . GLU A 1 324 ? 1.001   -37.451 18.260  1.000 49.180  0 328 GLU A C   1 
ATOM   2403 O O   . GLU A 1 324 ? 1.859   -38.320 18.461  1.000 45.770  0 328 GLU A O   1 
ATOM   2404 C CB  . GLU A 1 324 ? -0.851  -38.396 19.670  1.000 49.690  0 328 GLU A CB  1 
ATOM   2405 C CG  . GLU A 1 324 ? -0.474  -37.526 20.832  1.000 55.030  0 328 GLU A CG  1 
ATOM   2406 C CD  . GLU A 1 324 ? -1.164  -37.959 22.099  1.000 61.410  0 328 GLU A CD  1 
ATOM   2407 O OE1 . GLU A 1 324 ? -0.478  -38.504 22.987  1.000 51.850  0 328 GLU A OE1 1 
ATOM   2408 O OE2 . GLU A 1 324 ? -2.394  -37.757 22.200  1.000 61.850  0 328 GLU A OE2 1 
ATOM   2409 N N   . ASN A 1 325 ? 1.297   -36.190 17.976  1.000 40.250  0 329 ASN A N   1 
ATOM   2410 C CA  . ASN A 1 325 ? 2.684   -35.781 17.838  1.000 45.890  0 329 ASN A CA  1 
ATOM   2411 C C   . ASN A 1 325 ? 3.344   -35.721 19.208  1.000 52.130  0 329 ASN A C   1 
ATOM   2412 O O   . ASN A 1 325 ? 2.767   -35.199 20.168  1.000 49.520  0 329 ASN A O   1 
ATOM   2413 C CB  . ASN A 1 325 ? 2.768   -34.427 17.137  1.000 48.500  0 329 ASN A CB  1 
ATOM   2414 C CG  . ASN A 1 325 ? 4.185   -33.942 17.000  1.000 47.970  0 329 ASN A CG  1 
ATOM   2415 O OD1 . ASN A 1 325 ? 4.599   -33.015 17.689  1.000 50.210  0 329 ASN A OD1 1 
ATOM   2416 N ND2 . ASN A 1 325 ? 4.949   -34.579 16.119  1.000 47.250  0 329 ASN A ND2 1 
ATOM   2417 N N   . ILE A 1 326 ? 4.547   -36.280 19.304  1.000 40.890  0 330 ILE A N   1 
ATOM   2418 C CA  . ILE A 1 326 ? 5.316   -36.213 20.539  1.000 42.930  0 330 ILE A CA  1 
ATOM   2419 C C   . ILE A 1 326 ? 6.218   -34.986 20.549  1.000 50.850  0 330 ILE A C   1 
ATOM   2420 O O   . ILE A 1 326 ? 6.264   -34.235 21.528  1.000 49.610  0 330 ILE A O   1 
ATOM   2421 C CB  . ILE A 1 326 ? 6.127   -37.516 20.722  1.000 42.430  0 330 ILE A CB  1 
ATOM   2422 C CG1 . ILE A 1 326 ? 5.189   -38.728 20.839  1.000 46.430  0 330 ILE A CG1 1 
ATOM   2423 C CG2 . ILE A 1 326 ? 7.037   -37.404 21.924  1.000 43.130  0 330 ILE A CG2 1 
ATOM   2424 C CD1 . ILE A 1 326 ? 5.846   -40.063 20.484  1.000 45.750  0 330 ILE A CD1 1 
ATOM   2425 N N   . LYS A 1 327 ? 6.936   -34.780 19.445  1.000 46.090  0 331 LYS A N   1 
ATOM   2426 C CA  . LYS A 1 327 ? 7.813   -33.653 19.157  1.000 46.540  0 331 LYS A CA  1 
ATOM   2427 C C   . LYS A 1 327 ? 8.075   -33.707 17.658  1.000 46.550  0 331 LYS A C   1 
ATOM   2428 O O   . LYS A 1 327 ? 7.636   -34.665 17.011  1.000 49.520  0 331 LYS A O   1 
ATOM   2429 C CB  . LYS A 1 327 ? 9.098   -33.727 19.988  1.000 42.660  0 331 LYS A CB  1 
ATOM   2430 C CG  . LYS A 1 327 ? 10.048  -34.842 19.618  1.000 44.310  0 331 LYS A CG  1 
ATOM   2431 C CD  . LYS A 1 327 ? 11.193  -34.864 20.603  1.000 48.320  0 331 LYS A CD  1 
ATOM   2432 C CE  . LYS A 1 327 ? 12.321  -35.749 20.128  1.000 42.660  0 331 LYS A CE  1 
ATOM   2433 N NZ  . LYS A 1 327 ? 13.596  -35.358 20.782  1.000 48.640  0 331 LYS A NZ  1 
ATOM   2434 N N   . PRO A 1 328 ? 8.727   -32.712 17.054  1.000 51.220  0 332 PRO A N   1 
ATOM   2435 C CA  . PRO A 1 328 ? 8.920   -32.754 15.602  1.000 44.950  0 332 PRO A CA  1 
ATOM   2436 C C   . PRO A 1 328 ? 9.566   -34.059 15.156  1.000 48.020  0 332 PRO A C   1 
ATOM   2437 O O   . PRO A 1 328 ? 10.586  -34.490 15.701  1.000 42.580  0 332 PRO A O   1 
ATOM   2438 C CB  . PRO A 1 328 ? 9.825   -31.548 15.340  1.000 54.030  0 332 PRO A CB  1 
ATOM   2439 C CG  . PRO A 1 328 ? 9.411   -30.579 16.381  1.000 54.060  0 332 PRO A CG  1 
ATOM   2440 C CD  . PRO A 1 328 ? 9.185   -31.424 17.608  1.000 55.950  0 332 PRO A CD  1 
ATOM   2441 N N   . GLN A 1 329 ? 8.919   -34.712 14.189  1.000 49.350  0 333 GLN A N   1 
ATOM   2442 C CA  . GLN A 1 329 ? 9.363   -35.934 13.527  1.000 53.210  0 333 GLN A CA  1 
ATOM   2443 C C   . GLN A 1 329 ? 9.297   -37.158 14.429  1.000 49.800  0 333 GLN A C   1 
ATOM   2444 O O   . GLN A 1 329 ? 9.882   -38.193 14.090  1.000 41.860  0 333 GLN A O   1 
ATOM   2445 C CB  . GLN A 1 329 ? 10.779  -35.782 12.949  1.000 46.490  0 333 GLN A CB  1 
ATOM   2446 C CG  . GLN A 1 329 ? 10.790  -35.023 11.626  1.000 41.790  0 333 GLN A CG  1 
ATOM   2447 C CD  . GLN A 1 329 ? 10.757  -33.526 11.821  1.000 47.850  0 333 GLN A CD  1 
ATOM   2448 O OE1 . GLN A 1 329 ? 11.626  -32.956 12.483  1.000 58.620  0 333 GLN A OE1 1 
ATOM   2449 N NE2 . GLN A 1 329 ? 9.750   -32.875 11.246  1.000 55.640  0 333 GLN A NE2 1 
ATOM   2450 N N   . VAL A 1 330 ? 8.612   -37.071 15.569  1.000 38.490  0 334 VAL A N   1 
ATOM   2451 C CA  . VAL A 1 330 ? 8.356   -38.219 16.438  1.000 41.830  0 334 VAL A CA  1 
ATOM   2452 C C   . VAL A 1 330 ? 6.857   -38.249 16.709  1.000 45.780  0 334 VAL A C   1 
ATOM   2453 O O   . VAL A 1 330 ? 6.310   -37.293 17.273  1.000 43.700  0 334 VAL A O   1 
ATOM   2454 C CB  . VAL A 1 330 ? 9.148   -38.151 17.755  1.000 41.670  0 334 VAL A CB  1 
ATOM   2455 C CG1 . VAL A 1 330 ? 9.023   -39.473 18.517  1.000 36.310  0 334 VAL A CG1 1 
ATOM   2456 C CG2 . VAL A 1 330 ? 10.634  -37.825 17.489  1.000 37.730  0 334 VAL A CG2 1 
ATOM   2457 N N   . ASP A 1 331 ? 6.187   -39.327 16.289  1.000 35.770  0 335 ASP A N   1 
ATOM   2458 C CA  . ASP A 1 331 ? 4.732   -39.408 16.388  1.000 38.580  0 335 ASP A CA  1 
ATOM   2459 C C   . ASP A 1 331 ? 4.285   -40.728 16.982  1.000 43.400  0 335 ASP A C   1 
ATOM   2460 O O   . ASP A 1 331 ? 4.847   -41.780 16.673  1.000 40.500  0 335 ASP A O   1 
ATOM   2461 C CB  . ASP A 1 331 ? 4.057   -39.269 15.025  1.000 42.430  0 335 ASP A CB  1 
ATOM   2462 C CG  . ASP A 1 331 ? 4.179   -37.888 14.470  1.000 48.610  0 335 ASP A CG  1 
ATOM   2463 O OD1 . ASP A 1 331 ? 3.526   -36.979 15.018  1.000 44.480  0 335 ASP A OD1 1 
ATOM   2464 O OD2 . ASP A 1 331 ? 4.946   -37.714 13.505  1.000 45.310  0 335 ASP A OD2 1 
ATOM   2465 N N   . HIS A 1 332 ? 3.237   -40.656 17.798  1.000 45.350  0 336 HIS A N   1 
ATOM   2466 C CA  . HIS A 1 332 ? 2.457   -41.815 18.193  1.000 49.460  0 336 HIS A CA  1 
ATOM   2467 C C   . HIS A 1 332 ? 1.336   -42.045 17.190  1.000 55.170  0 336 HIS A C   1 
ATOM   2468 O O   . HIS A 1 332 ? 0.641   -41.105 16.787  1.000 46.170  0 336 HIS A O   1 
ATOM   2469 C CB  . HIS A 1 332 ? 1.843   -41.614 19.578  1.000 45.540  0 336 HIS A CB  1 
ATOM   2470 C CG  . HIS A 1 332 ? 2.676   -42.148 20.697  1.000 43.920  0 336 HIS A CG  1 
ATOM   2471 N ND1 . HIS A 1 332 ? 2.727   -41.543 21.934  1.000 47.400  0 336 HIS A ND1 1 
ATOM   2472 C CD2 . HIS A 1 332 ? 3.472   -43.240 20.777  1.000 42.290  0 336 HIS A CD2 1 
ATOM   2473 C CE1 . HIS A 1 332 ? 3.521   -42.239 22.727  1.000 42.620  0 336 HIS A CE1 1 
ATOM   2474 N NE2 . HIS A 1 332 ? 3.978   -43.278 22.052  1.000 43.530  0 336 HIS A NE2 1 
ATOM   2475 N N   . VAL A 1 333 ? 1.159   -43.301 16.800  1.000 43.520  0 337 VAL A N   1 
ATOM   2476 C CA  . VAL A 1 333 ? -0.023  -43.752 16.078  1.000 46.940  0 337 VAL A CA  1 
ATOM   2477 C C   . VAL A 1 333 ? -0.804  -44.641 17.031  1.000 44.350  0 337 VAL A C   1 
ATOM   2478 O O   . VAL A 1 333 ? -0.289  -45.663 17.499  1.000 41.730  0 337 VAL A O   1 
ATOM   2479 C CB  . VAL A 1 333 ? 0.352   -44.501 14.792  1.000 47.260  0 337 VAL A CB  1 
ATOM   2480 C CG1 . VAL A 1 333 ? -0.873  -45.077 14.146  1.000 48.060  0 337 VAL A CG1 1 
ATOM   2481 C CG2 . VAL A 1 333 ? 1.093   -43.571 13.846  1.000 45.620  0 337 VAL A CG2 1 
ATOM   2482 N N   . ILE A 1 334 ? -2.033  -44.250 17.344  1.000 46.560  0 338 ILE A N   1 
ATOM   2483 C CA  . ILE A 1 334 ? -2.825  -44.960 18.342  1.000 48.080  0 338 ILE A CA  1 
ATOM   2484 C C   . ILE A 1 334 ? -3.789  -45.890 17.615  1.000 48.660  0 338 ILE A C   1 
ATOM   2485 O O   . ILE A 1 334 ? -4.607  -45.445 16.798  1.000 44.740  0 338 ILE A O   1 
ATOM   2486 C CB  . ILE A 1 334 ? -3.561  -43.985 19.271  1.000 52.950  0 338 ILE A CB  1 
ATOM   2487 C CG1 . ILE A 1 334 ? -2.564  -42.986 19.872  1.000 57.490  0 338 ILE A CG1 1 
ATOM   2488 C CG2 . ILE A 1 334 ? -4.305  -44.750 20.368  1.000 47.540  0 338 ILE A CG2 1 
ATOM   2489 C CD1 . ILE A 1 334 ? -3.173  -41.643 20.264  1.000 54.920  0 338 ILE A CD1 1 
ATOM   2490 N N   . PHE A 1 335 ? -3.676  -47.183 17.900  1.000 44.040  0 339 PHE A N   1 
ATOM   2491 C CA  . PHE A 1 335 ? -4.558  -48.190 17.334  1.000 47.740  0 339 PHE A CA  1 
ATOM   2492 C C   . PHE A 1 335 ? -5.859  -48.249 18.127  1.000 46.550  0 339 PHE A C   1 
ATOM   2493 O O   . PHE A 1 335 ? -5.899  -47.864 19.298  1.000 48.390  0 339 PHE A O   1 
ATOM   2494 C CB  . PHE A 1 335 ? -3.868  -49.553 17.330  1.000 43.720  0 339 PHE A CB  1 
ATOM   2495 C CG  . PHE A 1 335 ? -2.859  -49.710 16.215  1.000 46.690  0 339 PHE A CG  1 
ATOM   2496 C CD1 . PHE A 1 335 ? -1.689  -48.992 16.232  1.000 48.080  0 339 PHE A CD1 1 
ATOM   2497 C CD2 . PHE A 1 335 ? -3.115  -50.549 15.137  1.000 48.950  0 339 PHE A CD2 1 
ATOM   2498 C CE1 . PHE A 1 335 ? -0.750  -49.119 15.198  1.000 54.640  0 339 PHE A CE1 1 
ATOM   2499 C CE2 . PHE A 1 335 ? -2.188  -50.679 14.098  1.000 45.910  0 339 PHE A CE2 1 
ATOM   2500 C CZ  . PHE A 1 335 ? -1.012  -49.960 14.131  1.000 47.110  0 339 PHE A CZ  1 
ATOM   2501 N N   . PRO A 1 336 ? -6.939  -48.736 17.509  1.000 51.960  0 340 PRO A N   1 
ATOM   2502 C CA  . PRO A 1 336 ? -8.248  -48.722 18.191  1.000 52.540  0 340 PRO A CA  1 
ATOM   2503 C C   . PRO A 1 336 ? -8.290  -49.512 19.492  1.000 54.230  0 340 PRO A C   1 
ATOM   2504 O O   . PRO A 1 336 ? -9.147  -49.223 20.341  1.000 56.780  0 340 PRO A O   1 
ATOM   2505 C CB  . PRO A 1 336 ? -9.194  -49.322 17.142  1.000 60.960  0 340 PRO A CB  1 
ATOM   2506 C CG  . PRO A 1 336 ? -8.517  -49.041 15.817  1.000 53.410  0 340 PRO A CG  1 
ATOM   2507 C CD  . PRO A 1 336 ? -7.047  -49.176 16.105  1.000 50.170  0 340 PRO A CD  1 
ATOM   2508 N N   . ASP A 1 337 ? -7.412  -50.497 19.676  1.000 54.580  0 341 ASP A N   1 
ATOM   2509 C CA  . ASP A 1 337 ? -7.312  -51.225 20.938  1.000 56.980  0 341 ASP A CA  1 
ATOM   2510 C C   . ASP A 1 337 ? -6.449  -50.501 21.970  1.000 56.900  0 341 ASP A C   1 
ATOM   2511 O O   . ASP A 1 337 ? -6.149  -51.075 23.020  1.000 52.630  0 341 ASP A O   1 
ATOM   2512 C CB  . ASP A 1 337 ? -6.763  -52.639 20.696  1.000 60.220  0 341 ASP A CB  1 
ATOM   2513 C CG  . ASP A 1 337 ? -5.285  -52.649 20.323  1.000 64.420  0 341 ASP A CG  1 
ATOM   2514 O OD1 . ASP A 1 337 ? -4.730  -51.582 19.985  1.000 62.750  0 341 ASP A OD1 1 
ATOM   2515 O OD2 . ASP A 1 337 ? -4.669  -53.736 20.362  1.000 66.350  0 341 ASP A OD2 1 
ATOM   2516 N N   . GLY A 1 338 ? -6.029  -49.269 21.688  1.000 53.530  0 342 GLY A N   1 
ATOM   2517 C CA  . GLY A 1 338 ? -5.252  -48.483 22.619  1.000 49.930  0 342 GLY A CA  1 
ATOM   2518 C C   . GLY A 1 338 ? -3.755  -48.639 22.494  1.000 49.280  0 342 GLY A C   1 
ATOM   2519 O O   . GLY A 1 338 ? -3.009  -47.787 23.007  1.000 51.550  0 342 GLY A O   1 
ATOM   2520 N N   . LYS A 1 339 ? -3.288  -49.696 21.830  1.000 45.060  0 343 LYS A N   1 
ATOM   2521 C CA  . LYS A 1 339 ? -1.853  -49.874 21.630  1.000 42.660  0 343 LYS A CA  1 
ATOM   2522 C C   . LYS A 1 339 ? -1.286  -48.770 20.743  1.000 43.120  0 343 LYS A C   1 
ATOM   2523 O O   . LYS A 1 339 ? -1.919  -48.337 19.776  1.000 47.720  0 343 LYS A O   1 
ATOM   2524 C CB  . LYS A 1 339 ? -1.582  -51.242 21.001  1.000 50.380  0 343 LYS A CB  1 
ATOM   2525 C CG  . LYS A 1 339 ? -0.116  -51.608 20.877  1.000 55.830  0 343 LYS A CG  1 
ATOM   2526 C CD  . LYS A 1 339 ? 0.414   -51.393 19.459  1.000 61.670  0 343 LYS A CD  1 
ATOM   2527 C CE  . LYS A 1 339 ? -0.455  -52.120 18.443  1.000 55.720  0 343 LYS A CE  1 
ATOM   2528 N NZ  . LYS A 1 339 ? 0.252   -52.322 17.164  1.000 51.750  0 343 LYS A NZ  1 
ATOM   2529 N N   . ARG A 1 340 ? -0.066  -48.334 21.065  1.000 44.310  0 344 ARG A N   1 
ATOM   2530 C CA  . ARG A 1 340 ? 0.602   -47.267 20.343  1.000 41.520  0 344 ARG A CA  1 
ATOM   2531 C C   . ARG A 1 340 ? 1.920   -47.759 19.755  1.000 42.790  0 344 ARG A C   1 
ATOM   2532 O O   . ARG A 1 340 ? 2.626   -48.589 20.343  1.000 43.830  0 344 ARG A O   1 
ATOM   2533 C CB  . ARG A 1 340 ? 0.895   -46.053 21.247  1.000 45.370  0 344 ARG A CB  1 
ATOM   2534 C CG  . ARG A 1 340 ? -0.328  -45.356 21.812  1.000 51.430  0 344 ARG A CG  1 
ATOM   2535 C CD  . ARG A 1 340 ? 0.094   -44.209 22.718  1.000 52.290  0 344 ARG A CD  1 
ATOM   2536 N NE  . ARG A 1 340 ? -1.069  -43.590 23.331  1.000 52.410  0 344 ARG A NE  1 
ATOM   2537 C CZ  . ARG A 1 340 ? -1.259  -42.282 23.451  1.000 51.470  0 344 ARG A CZ  1 
ATOM   2538 N NH1 . ARG A 1 340 ? -0.351  -41.429 23.010  1.000 51.320  0 344 ARG A NH1 1 
ATOM   2539 N NH2 . ARG A 1 340 ? -2.370  -41.831 24.016  1.000 49.200  0 344 ARG A NH2 1 
ATOM   2540 N N   . ILE A 1 341 ? 2.255   -47.223 18.596  1.000 38.950  0 345 ILE A N   1 
ATOM   2541 C CA  . ILE A 1 341 ? 3.601   -47.375 18.073  1.000 38.710  0 345 ILE A CA  1 
ATOM   2542 C C   . ILE A 1 341 ? 4.185   -45.987 17.882  1.000 38.950  0 345 ILE A C   1 
ATOM   2543 O O   . ILE A 1 341 ? 3.471   -44.997 17.692  1.000 42.200  0 345 ILE A O   1 
ATOM   2544 C CB  . ILE A 1 341 ? 3.660   -48.190 16.762  1.000 48.080  0 345 ILE A CB  1 
ATOM   2545 C CG1 . ILE A 1 341 ? 2.923   -47.474 15.641  1.000 54.750  0 345 ILE A CG1 1 
ATOM   2546 C CG2 . ILE A 1 341 ? 3.082   -49.582 16.969  1.000 56.030  0 345 ILE A CG2 1 
ATOM   2547 C CD1 . ILE A 1 341 ? 2.994   -48.216 14.324  1.000 66.540  0 345 ILE A CD1 1 
ATOM   2548 N N   . ILE A 1 342 ? 5.504   -45.930 17.977  1.000 37.650  0 346 ILE A N   1 
ATOM   2549 C CA  . ILE A 1 342 ? 6.276   -44.727 17.738  1.000 39.210  0 346 ILE A CA  1 
ATOM   2550 C C   . ILE A 1 342 ? 6.836   -44.845 16.333  1.000 41.120  0 346 ILE A C   1 
ATOM   2551 O O   . ILE A 1 342 ? 7.579   -45.788 16.032  1.000 42.170  0 346 ILE A O   1 
ATOM   2552 C CB  . ILE A 1 342 ? 7.401   -44.574 18.772  1.000 43.070  0 346 ILE A CB  1 
ATOM   2553 C CG1 . ILE A 1 342 ? 6.822   -44.488 20.193  1.000 42.750  0 346 ILE A CG1 1 
ATOM   2554 C CG2 . ILE A 1 342 ? 8.283   -43.364 18.431  1.000 43.180  0 346 ILE A CG2 1 
ATOM   2555 C CD1 . ILE A 1 342 ? 7.883   -44.707 21.301  1.000 37.180  0 346 ILE A CD1 1 
ATOM   2556 N N   . ILE A 1 343 ? 6.466   -43.909 15.466  1.000 38.380  0 347 ILE A N   1 
ATOM   2557 C CA  . ILE A 1 343 ? 6.993   -43.844 14.107  1.000 40.550  0 347 ILE A CA  1 
ATOM   2558 C C   . ILE A 1 343 ? 7.853   -42.598 13.980  1.000 36.870  0 347 ILE A C   1 
ATOM   2559 O O   . ILE A 1 343 ? 7.463   -41.514 14.435  1.000 35.850  0 347 ILE A O   1 
ATOM   2560 C CB  . ILE A 1 343 ? 5.863   -43.877 13.067  1.000 47.350  0 347 ILE A CB  1 
ATOM   2561 C CG1 . ILE A 1 343 ? 4.832   -44.900 13.502  1.000 53.000  0 347 ILE A CG1 1 
ATOM   2562 C CG2 . ILE A 1 343 ? 6.389   -44.163 11.655  1.000 53.600  0 347 ILE A CG2 1 
ATOM   2563 C CD1 . ILE A 1 343 ? 3.838   -45.160 12.480  1.000 59.240  0 347 ILE A CD1 1 
ATOM   2564 N N   . LEU A 1 344 ? 9.034   -42.761 13.394  1.000 39.300  0 348 LEU A N   1 
ATOM   2565 C CA  . LEU A 1 344 ? 10.007  -41.683 13.282  1.000 40.920  0 348 LEU A CA  1 
ATOM   2566 C C   . LEU A 1 344 ? 9.920   -41.044 11.896  1.000 41.260  0 348 LEU A C   1 
ATOM   2567 O O   . LEU A 1 344 ? 9.878   -41.747 10.881  1.000 40.510  0 348 LEU A O   1 
ATOM   2568 C CB  . LEU A 1 344 ? 11.422  -42.202 13.561  1.000 35.200  0 348 LEU A CB  1 
ATOM   2569 C CG  . LEU A 1 344 ? 11.600  -42.906 14.921  1.000 37.360  0 348 LEU A CG  1 
ATOM   2570 C CD1 . LEU A 1 344 ? 13.080  -43.159 15.278  1.000 34.550  0 348 LEU A CD1 1 
ATOM   2571 C CD2 . LEU A 1 344 ? 10.901  -42.146 16.072  1.000 42.910  0 348 LEU A CD2 1 
ATOM   2572 N N   . ALA A 1 345 ? 9.872   -39.708 11.863  1.000 41.620  0 349 ALA A N   1 
ATOM   2573 C CA  . ALA A 1 345 ? 9.936   -38.924 10.614  1.000 37.460  0 349 ALA A CA  1 
ATOM   2574 C C   . ALA A 1 345 ? 8.882   -39.351 9.592   1.000 37.490  0 349 ALA A C   1 
ATOM   2575 O O   . ALA A 1 345 ? 9.100   -39.254 8.384   1.000 39.840  0 349 ALA A O   1 
ATOM   2576 C CB  . ALA A 1 345 ? 11.337  -38.985 9.987   1.000 36.210  0 349 ALA A CB  1 
ATOM   2577 N N   . GLU A 1 346 ? 7.717   -39.820 10.059  1.000 37.400  0 350 GLU A N   1 
ATOM   2578 C CA  . GLU A 1 346 ? 6.650   -40.278 9.162   1.000 38.610  0 350 GLU A CA  1 
ATOM   2579 C C   . GLU A 1 346 ? 7.158   -41.324 8.165   1.000 36.980  0 350 GLU A C   1 
ATOM   2580 O O   . GLU A 1 346 ? 6.668   -41.420 7.038   1.000 40.910  0 350 GLU A O   1 
ATOM   2581 C CB  . GLU A 1 346 ? 5.998   -39.100 8.429   1.000 43.830  0 350 GLU A CB  1 
ATOM   2582 C CG  . GLU A 1 346 ? 5.393   -38.065 9.362   1.000 43.000  0 350 GLU A CG  1 
ATOM   2583 C CD  . GLU A 1 346 ? 4.969   -36.786 8.638   1.000 45.870  0 350 GLU A CD  1 
ATOM   2584 O OE1 . GLU A 1 346 ? 4.905   -35.740 9.302   1.000 51.600  0 350 GLU A OE1 1 
ATOM   2585 O OE2 . GLU A 1 346 ? 4.715   -36.822 7.420   1.000 52.210  0 350 GLU A OE2 1 
ATOM   2586 N N   . GLY A 1 347 ? 8.132   -42.134 8.584   1.000 36.500  0 351 GLY A N   1 
ATOM   2587 C CA  . GLY A 1 347 ? 8.698   -43.160 7.727   1.000 35.360  0 351 GLY A CA  1 
ATOM   2588 C C   . GLY A 1 347 ? 9.754   -42.686 6.742   1.000 42.280  0 351 GLY A C   1 
ATOM   2589 O O   . GLY A 1 347 ? 10.254  -43.508 5.965   1.000 38.150  0 351 GLY A O   1 
ATOM   2590 N N   . ARG A 1 348 ? 10.098  -41.394 6.736   1.000 35.470  0 352 ARG A N   1 
ATOM   2591 C CA  . ARG A 1 348 ? 11.181  -40.876 5.907   1.000 35.840  0 352 ARG A CA  1 
ATOM   2592 C C   . ARG A 1 348 ? 12.534  -41.141 6.579   1.000 32.440  0 352 ARG A C   1 
ATOM   2593 O O   . ARG A 1 348 ? 12.616  -41.396 7.787   1.000 37.990  0 352 ARG A O   1 
ATOM   2594 C CB  . ARG A 1 348 ? 11.012  -39.372 5.645   1.000 34.760  0 352 ARG A CB  1 
ATOM   2595 C CG  . ARG A 1 348 ? 10.005  -38.985 4.513   1.000 36.600  0 352 ARG A CG  1 
ATOM   2596 C CD  . ARG A 1 348 ? 8.555   -39.060 4.980   1.000 41.340  0 352 ARG A CD  1 
ATOM   2597 N NE  . ARG A 1 348 ? 7.622   -38.701 3.909   1.000 40.550  0 352 ARG A NE  1 
ATOM   2598 C CZ  . ARG A 1 348 ? 6.340   -39.059 3.869   1.000 46.620  0 352 ARG A CZ  1 
ATOM   2599 N NH1 . ARG A 1 348 ? 5.811   -39.795 4.847   1.000 40.900  0 352 ARG A NH1 1 
ATOM   2600 N NH2 . ARG A 1 348 ? 5.584   -38.677 2.845   1.000 40.150  0 352 ARG A NH2 1 
ATOM   2601 N N   . LEU A 1 349 ? 13.595  -41.090 5.769   1.000 34.610  0 353 LEU A N   1 
ATOM   2602 C CA  . LEU A 1 349 ? 14.975  -41.376 6.197   1.000 36.390  0 353 LEU A CA  1 
ATOM   2603 C C   . LEU A 1 349 ? 15.254  -40.917 7.627   1.000 38.330  0 353 LEU A C   1 
ATOM   2604 O O   . LEU A 1 349 ? 15.300  -39.710 7.893   1.000 40.310  0 353 LEU A O   1 
ATOM   2605 C CB  . LEU A 1 349 ? 15.968  -40.692 5.246   1.000 43.330  0 353 LEU A CB  1 
ATOM   2606 C CG  . LEU A 1 349 ? 16.232  -41.313 3.879   1.000 55.330  0 353 LEU A CG  1 
ATOM   2607 C CD1 . LEU A 1 349 ? 16.545  -40.257 2.832   1.000 52.390  0 353 LEU A CD1 1 
ATOM   2608 C CD2 . LEU A 1 349 ? 17.373  -42.300 3.984   1.000 48.630  0 353 LEU A CD2 1 
ATOM   2609 N N   . VAL A 1 350 ? 15.457  -41.861 8.550   1.000 34.140  0 354 VAL A N   1 
ATOM   2610 C CA  . VAL A 1 350 ? 15.457  -41.518 9.974   1.000 33.580  0 354 VAL A CA  1 
ATOM   2611 C C   . VAL A 1 350 ? 16.733  -40.793 10.378  1.000 36.730  0 354 VAL A C   1 
ATOM   2612 O O   . VAL A 1 350 ? 16.710  -39.920 11.254  1.000 36.290  0 354 VAL A O   1 
ATOM   2613 C CB  . VAL A 1 350 ? 15.247  -42.782 10.836  1.000 34.640  0 354 VAL A CB  1 
ATOM   2614 C CG1 . VAL A 1 350 ? 16.429  -43.751 10.687  1.000 35.640  0 354 VAL A CG1 1 
ATOM   2615 C CG2 . VAL A 1 350 ? 15.087  -42.404 12.291  1.000 34.250  0 354 VAL A CG2 1 
ATOM   2616 N N   . ASN A 1 351 ? 17.872  -41.156 9.788   1.000 36.300  0 355 ASN A N   1 
ATOM   2617 C CA  . ASN A 1 351 ? 19.111  -40.516 10.205  1.000 39.600  0 355 ASN A CA  1 
ATOM   2618 C C   . ASN A 1 351 ? 19.132  -39.050 9.803   1.000 40.980  0 355 ASN A C   1 
ATOM   2619 O O   . ASN A 1 351 ? 19.748  -38.234 10.498  1.000 41.470  0 355 ASN A O   1 
ATOM   2620 C CB  . ASN A 1 351 ? 20.328  -41.261 9.644   1.000 38.750  0 355 ASN A CB  1 
ATOM   2621 C CG  . ASN A 1 351 ? 20.323  -41.369 8.129   1.000 42.190  0 355 ASN A CG  1 
ATOM   2622 O OD1 . ASN A 1 351 ? 19.282  -41.569 7.499   1.000 39.470  0 355 ASN A OD1 1 
ATOM   2623 N ND2 . ASN A 1 351 ? 21.504  -41.251 7.536   1.000 40.590  0 355 ASN A ND2 1 
ATOM   2624 N N   . LEU A 1 352 ? 18.441  -38.691 8.716   1.000 36.840  0 356 LEU A N   1 
ATOM   2625 C CA  . LEU A 1 352 ? 18.393  -37.309 8.251   1.000 39.010  0 356 LEU A CA  1 
ATOM   2626 C C   . LEU A 1 352 ? 17.153  -36.562 8.716   1.000 43.070  0 356 LEU A C   1 
ATOM   2627 O O   . LEU A 1 352 ? 17.195  -35.330 8.835   1.000 43.680  0 356 LEU A O   1 
ATOM   2628 C CB  . LEU A 1 352 ? 18.480  -37.263 6.717   1.000 40.550  0 356 LEU A CB  1 
ATOM   2629 C CG  . LEU A 1 352 ? 19.875  -37.591 6.141   1.000 40.890  0 356 LEU A CG  1 
ATOM   2630 C CD1 . LEU A 1 352 ? 19.806  -38.604 5.011   1.000 46.360  0 356 LEU A CD1 1 
ATOM   2631 C CD2 . LEU A 1 352 ? 20.611  -36.336 5.670   1.000 42.470  0 356 LEU A CD2 1 
ATOM   2632 N N   . GLY A 1 353 ? 16.062  -37.276 8.997   1.000 39.130  0 357 GLY A N   1 
ATOM   2633 C CA  . GLY A 1 353 ? 14.841  -36.679 9.491   1.000 43.420  0 357 GLY A CA  1 
ATOM   2634 C C   . GLY A 1 353 ? 14.838  -36.388 10.979  1.000 44.580  0 357 GLY A C   1 
ATOM   2635 O O   . GLY A 1 353 ? 14.355  -35.335 11.406  1.000 42.220  0 357 GLY A O   1 
ATOM   2636 N N   . CYS A 1 354 ? 15.372  -37.314 11.778  1.000 34.460  0 358 CYS A N   1 
ATOM   2637 C CA  . CYS A 1 354 ? 15.422  -37.160 13.226  1.000 39.120  0 358 CYS A CA  1 
ATOM   2638 C C   . CYS A 1 354 ? 16.799  -36.760 13.730  1.000 40.480  0 358 CYS A C   1 
ATOM   2639 O O   . CYS A 1 354 ? 16.944  -36.472 14.923  1.000 38.390  0 358 CYS A O   1 
ATOM   2640 C CB  . CYS A 1 354 ? 14.986  -38.464 13.911  1.000 40.440  0 358 CYS A CB  1 
ATOM   2641 S SG  . CYS A 1 354 ? 13.266  -38.886 13.562  1.000 39.550  0 358 CYS A SG  1 
ATOM   2642 N N   . ALA A 1 355 ? 17.803  -36.732 12.854  1.000 43.350  0 359 ALA A N   1 
ATOM   2643 C CA  . ALA A 1 355 ? 19.136  -36.261 13.213  1.000 42.380  0 359 ALA A CA  1 
ATOM   2644 C C   . ALA A 1 355 ? 19.733  -35.484 12.043  1.000 41.860  0 359 ALA A C   1 
ATOM   2645 O O   . ALA A 1 355 ? 18.994  -34.888 11.258  1.000 43.380  0 359 ALA A O   1 
ATOM   2646 C CB  . ALA A 1 355 ? 20.033  -37.437 13.616  1.000 42.190  0 359 ALA A CB  1 
ATOM   2647 N N   . THR A 1 356 ? 21.059  -35.487 11.904  1.000 47.020  0 360 THR A N   1 
ATOM   2648 C CA  . THR A 1 356 ? 21.736  -34.647 10.919  1.000 57.290  0 360 THR A CA  1 
ATOM   2649 C C   . THR A 1 356 ? 22.433  -35.448 9.819   1.000 56.930  0 360 THR A C   1 
ATOM   2650 O O   . THR A 1 356 ? 23.301  -34.907 9.124   1.000 59.250  0 360 THR A O   1 
ATOM   2651 C CB  . THR A 1 356 ? 22.748  -33.732 11.612  1.000 58.850  0 360 THR A CB  1 
ATOM   2652 O OG1 . THR A 1 356 ? 23.784  -34.530 12.206  1.000 66.850  0 360 THR A OG1 1 
ATOM   2653 C CG2 . THR A 1 356 ? 22.066  -32.890 12.680  1.000 63.850  0 360 THR A CG2 1 
ATOM   2654 N N   . GLY A 1 357 ? 22.075  -36.716 9.637   1.000 55.310  0 361 GLY A N   1 
ATOM   2655 C CA  . GLY A 1 357 ? 22.690  -37.495 8.578   1.000 58.320  0 361 GLY A CA  1 
ATOM   2656 C C   . GLY A 1 357 ? 24.095  -37.930 8.957   1.000 57.660  0 361 GLY A C   1 
ATOM   2657 O O   . GLY A 1 357 ? 24.527  -37.813 10.104  1.000 59.230  0 361 GLY A O   1 
ATOM   2658 N N   . HIS A 1 358 ? 24.818  -38.439 7.958   1.000 54.220  0 362 HIS A N   1 
ATOM   2659 C CA  . HIS A 1 358 ? 26.148  -38.972 8.222   1.000 45.870  0 362 HIS A CA  1 
ATOM   2660 C C   . HIS A 1 358 ? 27.125  -37.868 8.630   1.000 48.040  0 362 HIS A C   1 
ATOM   2661 O O   . HIS A 1 358 ? 27.019  -36.716 8.183   1.000 43.650  0 362 HIS A O   1 
ATOM   2662 C CB  . HIS A 1 358 ? 26.731  -39.683 7.005   1.000 46.020  0 362 HIS A CB  1 
ATOM   2663 C CG  . HIS A 1 358 ? 25.995  -40.911 6.587   1.000 43.220  0 362 HIS A CG  1 
ATOM   2664 N ND1 . HIS A 1 358 ? 24.971  -41.476 7.326   1.000 43.530  0 362 HIS A ND1 1 
ATOM   2665 C CD2 . HIS A 1 358 ? 26.144  -41.687 5.490   1.000 41.730  0 362 HIS A CD2 1 
ATOM   2666 C CE1 . HIS A 1 358 ? 24.514  -42.540 6.692   1.000 40.210  0 362 HIS A CE1 1 
ATOM   2667 N NE2 . HIS A 1 358 ? 25.205  -42.689 5.573   1.000 46.080  0 362 HIS A NE2 1 
ATOM   2668 N N   . PRO A 1 359 ? 28.125  -38.220 9.431   1.000 50.330  0 363 PRO A N   1 
ATOM   2669 C CA  . PRO A 1 359 ? 29.158  -37.258 9.799   1.000 43.680  0 363 PRO A CA  1 
ATOM   2670 C C   . PRO A 1 359 ? 29.994  -36.872 8.591   1.000 38.010  0 363 PRO A C   1 
ATOM   2671 O O   . PRO A 1 359 ? 30.020  -37.541 7.551   1.000 38.710  0 363 PRO A O   1 
ATOM   2672 C CB  . PRO A 1 359 ? 30.015  -38.005 10.822  1.000 56.620  0 363 PRO A CB  1 
ATOM   2673 C CG  . PRO A 1 359 ? 29.434  -39.405 10.910  1.000 59.470  0 363 PRO A CG  1 
ATOM   2674 C CD  . PRO A 1 359 ? 28.505  -39.598 9.784   1.000 54.520  0 363 PRO A CD  1 
ATOM   2675 N N   . SER A 1 360 ? 30.738  -35.792 8.800   1.000 36.090  0 364 SER A N   1 
ATOM   2676 C CA  . SER A 1 360 ? 31.421  -35.092 7.724   1.000 38.340  0 364 SER A CA  1 
ATOM   2677 C C   . SER A 1 360 ? 32.472  -35.964 7.054   1.000 36.600  0 364 SER A C   1 
ATOM   2678 O O   . SER A 1 360 ? 32.604  -35.945 5.826   1.000 37.190  0 364 SER A O   1 
ATOM   2679 C CB  . SER A 1 360 ? 32.047  -33.812 8.283   1.000 36.500  0 364 SER A CB  1 
ATOM   2680 O OG  . SER A 1 360 ? 31.063  -33.033 8.932   1.000 39.850  0 364 SER A OG  1 
ATOM   2681 N N   . PHE A 1 361 ? 33.242  -36.721 7.839   1.000 31.710  0 365 PHE A N   1 
ATOM   2682 C CA  . PHE A 1 361 ? 34.387  -37.433 7.268   1.000 32.980  0 365 PHE A CA  1 
ATOM   2683 C C   . PHE A 1 361 ? 33.945  -38.401 6.179   1.000 31.750  0 365 PHE A C   1 
ATOM   2684 O O   . PHE A 1 361 ? 34.523  -38.432 5.086   1.000 35.590  0 365 PHE A O   1 
ATOM   2685 C CB  . PHE A 1 361 ? 35.160  -38.167 8.360   1.000 33.750  0 365 PHE A CB  1 
ATOM   2686 C CG  . PHE A 1 361 ? 36.401  -38.873 7.854   1.000 33.830  0 365 PHE A CG  1 
ATOM   2687 C CD1 . PHE A 1 361 ? 37.517  -38.152 7.473   1.000 37.920  0 365 PHE A CD1 1 
ATOM   2688 C CD2 . PHE A 1 361 ? 36.432  -40.265 7.758   1.000 32.020  0 365 PHE A CD2 1 
ATOM   2689 C CE1 . PHE A 1 361 ? 38.661  -38.801 7.008   1.000 41.530  0 365 PHE A CE1 1 
ATOM   2690 C CE2 . PHE A 1 361 ? 37.560  -40.923 7.296   1.000 37.520  0 365 PHE A CE2 1 
ATOM   2691 C CZ  . PHE A 1 361 ? 38.682  -40.186 6.922   1.000 36.400  0 365 PHE A CZ  1 
ATOM   2692 N N   . VAL A 1 362 ? 32.903  -39.190 6.445   1.000 35.120  0 366 VAL A N   1 
ATOM   2693 C CA  . VAL A 1 362 ? 32.507  -40.162 5.435   1.000 33.340  0 366 VAL A CA  1 
ATOM   2694 C C   . VAL A 1 362 ? 31.752  -39.495 4.280   1.000 35.460  0 366 VAL A C   1 
ATOM   2695 O O   . VAL A 1 362 ? 31.902  -39.904 3.118   1.000 37.220  0 366 VAL A O   1 
ATOM   2696 C CB  . VAL A 1 362 ? 31.728  -41.313 6.093   1.000 38.230  0 366 VAL A CB  1 
ATOM   2697 C CG1 . VAL A 1 362 ? 30.257  -40.971 6.377   1.000 36.890  0 366 VAL A CG1 1 
ATOM   2698 C CG2 . VAL A 1 362 ? 31.879  -42.545 5.257   1.000 39.160  0 366 VAL A CG2 1 
ATOM   2699 N N   . MET A 1 363 ? 30.978  -38.442 4.553   1.000 33.680  0 367 MET A N   1 
ATOM   2700 C CA  . MET A 1 363 ? 30.366  -37.683 3.458   1.000 37.540  0 367 MET A CA  1 
ATOM   2701 C C   . MET A 1 363 ? 31.417  -37.076 2.532   1.000 34.360  0 367 MET A C   1 
ATOM   2702 O O   . MET A 1 363 ? 31.167  -36.889 1.338   1.000 34.400  0 367 MET A O   1 
ATOM   2703 C CB  . MET A 1 363 ? 29.464  -36.579 4.021   1.000 36.740  0 367 MET A CB  1 
ATOM   2704 C CG  . MET A 1 363 ? 28.224  -37.100 4.766   1.000 34.550  0 367 MET A CG  1 
ATOM   2705 S SD  . MET A 1 363 ? 27.501  -38.585 3.990   1.000 40.060  0 367 MET A SD  1 
ATOM   2706 C CE  . MET A 1 363 ? 26.977  -37.933 2.407   1.000 41.710  0 367 MET A CE  1 
ATOM   2707 N N   . SER A 1 364 ? 32.592  -36.750 3.065   1.000 33.990  0 368 SER A N   1 
ATOM   2708 C CA  . SER A 1 364 ? 33.687  -36.284 2.223   1.000 38.200  0 368 SER A CA  1 
ATOM   2709 C C   . SER A 1 364 ? 34.088  -37.329 1.188   1.000 32.610  0 368 SER A C   1 
ATOM   2710 O O   . SER A 1 364 ? 34.348  -36.996 0.027   1.000 37.520  0 368 SER A O   1 
ATOM   2711 C CB  . SER A 1 364 ? 34.875  -35.913 3.098   1.000 41.310  0 368 SER A CB  1 
ATOM   2712 O OG  . SER A 1 364 ? 35.931  -35.386 2.324   1.000 34.490  0 368 SER A OG  1 
ATOM   2713 N N   . ALA A 1 365 ? 34.150  -38.601 1.580   1.000 33.080  0 369 ALA A N   1 
ATOM   2714 C CA  . ALA A 1 365 ? 34.527  -39.607 0.598   1.000 38.010  0 369 ALA A CA  1 
ATOM   2715 C C   . ALA A 1 365 ? 33.468  -39.709 -0.493  1.000 35.980  0 369 ALA A C   1 
ATOM   2716 O O   . ALA A 1 365 ? 33.796  -39.729 -1.684  1.000 33.580  0 369 ALA A O   1 
ATOM   2717 C CB  . ALA A 1 365 ? 34.759  -40.960 1.281   1.000 32.960  0 369 ALA A CB  1 
ATOM   2718 N N   . SER A 1 366 ? 32.191  -39.712 -0.107  1.000 35.010  0 370 SER A N   1 
ATOM   2719 C CA  . SER A 1 366 ? 31.112  -39.745 -1.095  1.000 31.480  0 370 SER A CA  1 
ATOM   2720 C C   . SER A 1 366 ? 31.169  -38.535 -2.022  1.000 31.490  0 370 SER A C   1 
ATOM   2721 O O   . SER A 1 366 ? 31.075  -38.665 -3.249  1.000 39.110  0 370 SER A O   1 
ATOM   2722 C CB  . SER A 1 366 ? 29.764  -39.789 -0.383  1.000 35.820  0 370 SER A CB  1 
ATOM   2723 O OG  . SER A 1 366 ? 29.676  -40.922 0.457   1.000 38.980  0 370 SER A OG  1 
ATOM   2724 N N   . PHE A 1 367 ? 31.297  -37.345 -1.445  1.000 34.580  0 371 PHE A N   1 
ATOM   2725 C CA  . PHE A 1 367 ? 31.172  -36.121 -2.222  1.000 38.370  0 371 PHE A CA  1 
ATOM   2726 C C   . PHE A 1 367 ? 32.423  -35.829 -3.048  1.000 36.000  0 371 PHE A C   1 
ATOM   2727 O O   . PHE A 1 367 ? 32.320  -35.170 -4.086  1.000 37.490  0 371 PHE A O   1 
ATOM   2728 C CB  . PHE A 1 367 ? 30.860  -34.950 -1.292  1.000 34.670  0 371 PHE A CB  1 
ATOM   2729 C CG  . PHE A 1 367 ? 29.474  -34.999 -0.676  1.000 36.350  0 371 PHE A CG  1 
ATOM   2730 C CD1 . PHE A 1 367 ? 28.507  -35.876 -1.149  1.000 35.570  0 371 PHE A CD1 1 
ATOM   2731 C CD2 . PHE A 1 367 ? 29.149  -34.159 0.379   1.000 36.610  0 371 PHE A CD2 1 
ATOM   2732 C CE1 . PHE A 1 367 ? 27.240  -35.915 -0.575  1.000 36.780  0 371 PHE A CE1 1 
ATOM   2733 C CE2 . PHE A 1 367 ? 27.890  -34.189 0.953   1.000 38.090  0 371 PHE A CE2 1 
ATOM   2734 C CZ  . PHE A 1 367 ? 26.931  -35.068 0.468   1.000 38.750  0 371 PHE A CZ  1 
ATOM   2735 N N   . THR A 1 368 ? 33.603  -36.289 -2.611  1.000 38.460  0 372 THR A N   1 
ATOM   2736 C CA  . THR A 1 368 ? 34.773  -36.234 -3.495  1.000 33.660  0 372 THR A CA  1 
ATOM   2737 C C   . THR A 1 368 ? 34.513  -37.047 -4.758  1.000 38.720  0 372 THR A C   1 
ATOM   2738 O O   . THR A 1 368 ? 34.820  -36.603 -5.869  1.000 36.230  0 372 THR A O   1 
ATOM   2739 C CB  . THR A 1 368 ? 36.027  -36.751 -2.771  1.000 38.230  0 372 THR A CB  1 
ATOM   2740 O OG1 . THR A 1 368 ? 36.235  -36.020 -1.552  1.000 34.940  0 372 THR A OG1 1 
ATOM   2741 C CG2 . THR A 1 368 ? 37.282  -36.623 -3.649  1.000 37.130  0 372 THR A CG2 1 
ATOM   2742 N N   . ASN A 1 369 ? 33.904  -38.229 -4.608  1.000 36.740  0 373 ASN A N   1 
ATOM   2743 C CA  . ASN A 1 369 ? 33.479  -38.992 -5.777  1.000 36.220  0 373 ASN A CA  1 
ATOM   2744 C C   . ASN A 1 369 ? 32.499  -38.192 -6.636  1.000 34.660  0 373 ASN A C   1 
ATOM   2745 O O   . ASN A 1 369 ? 32.607  -38.190 -7.868  1.000 41.100  0 373 ASN A O   1 
ATOM   2746 C CB  . ASN A 1 369 ? 32.842  -40.316 -5.341  1.000 36.500  0 373 ASN A CB  1 
ATOM   2747 C CG  . ASN A 1 369 ? 33.875  -41.382 -5.015  1.000 35.250  0 373 ASN A CG  1 
ATOM   2748 O OD1 . ASN A 1 369 ? 34.570  -41.859 -5.905  1.000 39.860  0 373 ASN A OD1 1 
ATOM   2749 N ND2 . ASN A 1 369 ? 33.970  -41.763 -3.740  1.000 33.690  0 373 ASN A ND2 1 
ATOM   2750 N N   . GLN A 1 370 ? 31.533  -37.515 -6.008  1.000 32.000  0 374 GLN A N   1 
ATOM   2751 C CA  . GLN A 1 370 ? 30.593  -36.692 -6.778  1.000 33.130  0 374 GLN A CA  1 
ATOM   2752 C C   . GLN A 1 370 ? 31.329  -35.639 -7.607  1.000 36.350  0 374 GLN A C   1 
ATOM   2753 O O   . GLN A 1 370 ? 31.028  -35.437 -8.792  1.000 39.390  0 374 GLN A O   1 
ATOM   2754 C CB  . GLN A 1 370 ? 29.590  -36.006 -5.851  1.000 37.480  0 374 GLN A CB  1 
ATOM   2755 C CG  . GLN A 1 370 ? 28.373  -36.857 -5.470  1.000 34.080  0 374 GLN A CG  1 
ATOM   2756 C CD  . GLN A 1 370 ? 27.448  -37.144 -6.646  1.000 36.940  0 374 GLN A CD  1 
ATOM   2757 O OE1 . GLN A 1 370 ? 27.627  -36.619 -7.745  1.000 38.610  0 374 GLN A OE1 1 
ATOM   2758 N NE2 . GLN A 1 370 ? 26.463  -38.012 -6.421  1.000 43.120  0 374 GLN A NE2 1 
ATOM   2759 N N   . VAL A 1 371 ? 32.282  -34.936 -6.997  1.000 35.760  0 375 VAL A N   1 
ATOM   2760 C CA  . VAL A 1 371 ? 32.967  -33.871 -7.736  1.000 36.250  0 375 VAL A CA  1 
ATOM   2761 C C   . VAL A 1 371 ? 33.725  -34.450 -8.918  1.000 41.330  0 375 VAL A C   1 
ATOM   2762 O O   . VAL A 1 371 ? 33.730  -33.878 -10.019 1.000 38.970  0 375 VAL A O   1 
ATOM   2763 C CB  . VAL A 1 371 ? 33.902  -33.071 -6.811  1.000 38.180  0 375 VAL A CB  1 
ATOM   2764 C CG1 . VAL A 1 371 ? 34.732  -32.075 -7.636  1.000 35.960  0 375 VAL A CG1 1 
ATOM   2765 C CG2 . VAL A 1 371 ? 33.101  -32.342 -5.740  1.000 40.170  0 375 VAL A CG2 1 
ATOM   2766 N N   . LEU A 1 372 ? 34.395  -35.587 -8.711  1.000 39.840  0 376 LEU A N   1 
ATOM   2767 C CA  . LEU A 1 372 ? 35.153  -36.183 -9.804  1.000 38.810  0 376 LEU A CA  1 
ATOM   2768 C C   . LEU A 1 372 ? 34.236  -36.649 -10.925 1.000 38.510  0 376 LEU A C   1 
ATOM   2769 O O   . LEU A 1 372 ? 34.620  -36.586 -12.098 1.000 39.230  0 376 LEU A O   1 
ATOM   2770 C CB  . LEU A 1 372 ? 36.000  -37.349 -9.284  1.000 37.850  0 376 LEU A CB  1 
ATOM   2771 C CG  . LEU A 1 372 ? 37.141  -36.971 -8.316  1.000 37.750  0 376 LEU A CG  1 
ATOM   2772 C CD1 . LEU A 1 372 ? 37.669  -38.219 -7.576  1.000 40.300  0 376 LEU A CD1 1 
ATOM   2773 C CD2 . LEU A 1 372 ? 38.256  -36.270 -9.057  1.000 42.500  0 376 LEU A CD2 1 
ATOM   2774 N N   . ALA A 1 373 ? 33.036  -37.138 -10.585 1.000 38.570  0 377 ALA A N   1 
ATOM   2775 C CA  . ALA A 1 373 ? 32.094  -37.554 -11.618 1.000 36.330  0 377 ALA A CA  1 
ATOM   2776 C C   . ALA A 1 373 ? 31.616  -36.360 -12.424 1.000 38.080  0 377 ALA A C   1 
ATOM   2777 O O   . ALA A 1 373 ? 31.487  -36.440 -13.651 1.000 39.650  0 377 ALA A O   1 
ATOM   2778 C CB  . ALA A 1 373 ? 30.905  -38.280 -10.990 1.000 35.640  0 377 ALA A CB  1 
ATOM   2779 N N   . GLN A 1 374 ? 31.352  -35.242 -11.750 1.000 37.830  0 378 GLN A N   1 
ATOM   2780 C CA  . GLN A 1 374 ? 30.924  -34.042 -12.460 1.000 37.820  0 378 GLN A CA  1 
ATOM   2781 C C   . GLN A 1 374 ? 32.017  -33.540 -13.400 1.000 47.360  0 378 GLN A C   1 
ATOM   2782 O O   . GLN A 1 374 ? 31.739  -33.189 -14.553 1.000 41.960  0 378 GLN A O   1 
ATOM   2783 C CB  . GLN A 1 374 ? 30.518  -32.965 -11.454 1.000 38.160  0 378 GLN A CB  1 
ATOM   2784 C CG  . GLN A 1 374 ? 29.210  -33.285 -10.706 1.000 38.480  0 378 GLN A CG  1 
ATOM   2785 C CD  . GLN A 1 374 ? 27.979  -33.121 -11.584 1.000 41.270  0 378 GLN A CD  1 
ATOM   2786 O OE1 . GLN A 1 374 ? 27.884  -32.169 -12.352 1.000 40.430  0 378 GLN A OE1 1 
ATOM   2787 N NE2 . GLN A 1 374 ? 27.031  -34.056 -11.475 1.000 41.930  0 378 GLN A NE2 1 
ATOM   2788 N N   . ILE A 1 375 ? 33.270  -33.519 -12.935 1.000 43.050  0 379 ILE A N   1 
ATOM   2789 C CA  . ILE A 1 375 ? 34.377  -33.132 -13.812 1.000 46.050  0 379 ILE A CA  1 
ATOM   2790 C C   . ILE A 1 375 ? 34.436  -34.044 -15.030 1.000 38.480  0 379 ILE A C   1 
ATOM   2791 O O   . ILE A 1 375 ? 34.609  -33.586 -16.166 1.000 42.250  0 379 ILE A O   1 
ATOM   2792 C CB  . ILE A 1 375 ? 35.715  -33.153 -13.052 1.000 44.080  0 379 ILE A CB  1 
ATOM   2793 C CG1 . ILE A 1 375 ? 35.766  -32.062 -11.985 1.000 42.420  0 379 ILE A CG1 1 
ATOM   2794 C CG2 . ILE A 1 375 ? 36.871  -32.992 -14.034 1.000 48.390  0 379 ILE A CG2 1 
ATOM   2795 C CD1 . ILE A 1 375 ? 37.052  -32.101 -11.173 1.000 43.380  0 379 ILE A CD1 1 
ATOM   2796 N N   . GLU A 1 376 ? 34.320  -35.355 -14.807 1.000 41.920  0 380 GLU A N   1 
ATOM   2797 C CA  . GLU A 1 376 ? 34.434  -36.302 -15.912 1.000 47.090  0 380 GLU A CA  1 
ATOM   2798 C C   . GLU A 1 376 ? 33.290  -36.139 -16.911 1.000 47.470  0 380 GLU A C   1 
ATOM   2799 O O   . GLU A 1 376 ? 33.521  -36.127 -18.126 1.000 46.060  0 380 GLU A O   1 
ATOM   2800 C CB  . GLU A 1 376 ? 34.494  -37.731 -15.366 1.000 49.710  0 380 GLU A CB  1 
ATOM   2801 C CG  . GLU A 1 376 ? 34.304  -38.818 -16.416 1.000 47.660  0 380 GLU A CG  1 
ATOM   2802 C CD  . GLU A 1 376 ? 35.496  -38.980 -17.347 1.000 49.340  0 380 GLU A CD  1 
ATOM   2803 O OE1 . GLU A 1 376 ? 35.405  -39.838 -18.247 1.000 49.580  0 380 GLU A OE1 1 
ATOM   2804 O OE2 . GLU A 1 376 ? 36.513  -38.259 -17.193 1.000 46.250  0 380 GLU A OE2 1 
ATOM   2805 N N   . LEU A 1 377 ? 32.054  -35.997 -16.423 1.000 42.720  0 381 LEU A N   1 
ATOM   2806 C CA  . LEU A 1 377 ? 30.934  -35.776 -17.332 1.000 44.230  0 381 LEU A CA  1 
ATOM   2807 C C   . LEU A 1 377 ? 31.088  -34.458 -18.081 1.000 45.310  0 381 LEU A C   1 
ATOM   2808 O O   . LEU A 1 377 ? 30.945  -34.408 -19.305 1.000 47.260  0 381 LEU A O   1 
ATOM   2809 C CB  . LEU A 1 377 ? 29.616  -35.800 -16.562 1.000 38.970  0 381 LEU A CB  1 
ATOM   2810 C CG  . LEU A 1 377 ? 29.104  -37.177 -16.111 1.000 39.840  0 381 LEU A CG  1 
ATOM   2811 C CD1 . LEU A 1 377 ? 27.901  -37.001 -15.209 1.000 46.320  0 381 LEU A CD1 1 
ATOM   2812 C CD2 . LEU A 1 377 ? 28.762  -38.036 -17.327 1.000 39.240  0 381 LEU A CD2 1 
ATOM   2813 N N   . PHE A 1 378 ? 31.375  -33.373 -17.359 1.000 41.540  0 382 PHE A N   1 
ATOM   2814 C CA  . PHE A 1 378 ? 31.521  -32.076 -18.015 1.000 45.530  0 382 PHE A CA  1 
ATOM   2815 C C   . PHE A 1 378 ? 32.589  -32.122 -19.095 1.000 47.500  0 382 PHE A C   1 
ATOM   2816 O O   . PHE A 1 378 ? 32.409  -31.559 -20.180 1.000 49.190  0 382 PHE A O   1 
ATOM   2817 C CB  . PHE A 1 378 ? 31.855  -30.989 -16.990 1.000 47.730  0 382 PHE A CB  1 
ATOM   2818 C CG  . PHE A 1 378 ? 31.914  -29.600 -17.581 1.000 54.400  0 382 PHE A CG  1 
ATOM   2819 C CD1 . PHE A 1 378 ? 30.776  -29.005 -18.103 1.000 49.470  0 382 PHE A CD1 1 
ATOM   2820 C CD2 . PHE A 1 378 ? 33.107  -28.894 -17.619 1.000 48.880  0 382 PHE A CD2 1 
ATOM   2821 C CE1 . PHE A 1 378 ? 30.828  -27.730 -18.651 1.000 52.580  0 382 PHE A CE1 1 
ATOM   2822 C CE2 . PHE A 1 378 ? 33.164  -27.626 -18.167 1.000 54.470  0 382 PHE A CE2 1 
ATOM   2823 C CZ  . PHE A 1 378 ? 32.025  -27.041 -18.682 1.000 53.420  0 382 PHE A CZ  1 
ATOM   2824 N N   . GLN A 1 379 ? 33.701  -32.808 -18.829 1.000 49.830  0 383 GLN A N   1 
ATOM   2825 C CA  . GLN A 1 379 ? 34.791  -32.817 -19.798 1.000 55.600  0 383 GLN A CA  1 
ATOM   2826 C C   . GLN A 1 379 ? 34.585  -33.861 -20.891 1.000 56.030  0 383 GLN A C   1 
ATOM   2827 O O   . GLN A 1 379 ? 34.858  -33.591 -22.063 1.000 52.580  0 383 GLN A O   1 
ATOM   2828 C CB  . GLN A 1 379 ? 36.120  -33.058 -19.088 1.000 54.120  0 383 GLN A CB  1 
ATOM   2829 C CG  . GLN A 1 379 ? 36.542  -31.916 -18.200 1.000 54.800  0 383 GLN A CG  1 
ATOM   2830 C CD  . GLN A 1 379 ? 37.891  -32.156 -17.563 1.000 54.640  0 383 GLN A CD  1 
ATOM   2831 O OE1 . GLN A 1 379 ? 38.402  -33.276 -17.559 1.000 59.750  0 383 GLN A OE1 1 
ATOM   2832 N NE2 . GLN A 1 379 ? 38.479  -31.101 -17.020 1.000 48.330  0 383 GLN A NE2 1 
ATOM   2833 N N   . ASN A 1 380 ? 34.105  -35.055 -20.544 1.000 53.930  0 384 ASN A N   1 
ATOM   2834 C CA  . ASN A 1 380 ? 34.214  -36.173 -21.475 1.000 49.170  0 384 ASN A CA  1 
ATOM   2835 C C   . ASN A 1 380 ? 32.887  -36.876 -21.713 1.000 50.830  0 384 ASN A C   1 
ATOM   2836 O O   . ASN A 1 380 ? 32.873  -38.055 -22.082 1.000 49.860  0 384 ASN A O   1 
ATOM   2837 C CB  . ASN A 1 380 ? 35.258  -37.175 -20.987 1.000 51.790  0 384 ASN A CB  1 
ATOM   2838 C CG  . ASN A 1 380 ? 36.609  -36.532 -20.768 1.000 58.850  0 384 ASN A CG  1 
ATOM   2839 O OD1 . ASN A 1 380 ? 37.145  -35.890 -21.667 1.000 64.090  0 384 ASN A OD1 1 
ATOM   2840 N ND2 . ASN A 1 380 ? 37.160  -36.685 -19.567 1.000 61.910  0 384 ASN A ND2 1 
ATOM   2841 N N   . SER A 1 381 ? 31.764  -36.175 -21.526 1.000 49.400  0 385 SER A N   1 
ATOM   2842 C CA  . SER A 1 381 ? 30.473  -36.827 -21.738 1.000 56.860  0 385 SER A CA  1 
ATOM   2843 C C   . SER A 1 381 ? 30.336  -37.364 -23.156 1.000 57.200  0 385 SER A C   1 
ATOM   2844 O O   . SER A 1 381 ? 29.549  -38.290 -23.380 1.000 51.800  0 385 SER A O   1 
ATOM   2845 C CB  . SER A 1 381 ? 29.315  -35.872 -21.416 1.000 46.250  0 385 SER A CB  1 
ATOM   2846 O OG  . SER A 1 381 ? 29.242  -34.797 -22.327 1.000 50.170  0 385 SER A OG  1 
ATOM   2847 N N   . SER A 1 382 ? 31.112  -36.829 -24.105 1.000 53.100  0 386 SER A N   1 
ATOM   2848 C CA  . SER A 1 382 ? 31.052  -37.286 -25.490 1.000 61.170  0 386 SER A CA  1 
ATOM   2849 C C   . SER A 1 382 ? 31.506  -38.728 -25.648 1.000 62.730  0 386 SER A C   1 
ATOM   2850 O O   . SER A 1 382 ? 31.143  -39.377 -26.636 1.000 66.130  0 386 SER A O   1 
ATOM   2851 C CB  . SER A 1 382 ? 31.913  -36.387 -26.381 1.000 64.420  0 386 SER A CB  1 
ATOM   2852 O OG  . SER A 1 382 ? 31.293  -35.131 -26.586 1.000 79.760  0 386 SER A OG  1 
ATOM   2853 N N   . GLN A 1 383 ? 32.306  -39.235 -24.717 1.000 57.290  0 387 GLN A N   1 
ATOM   2854 C CA  . GLN A 1 383 ? 32.830  -40.589 -24.796 1.000 58.480  0 387 GLN A CA  1 
ATOM   2855 C C   . GLN A 1 383 ? 31.893  -41.617 -24.184 1.000 54.810  0 387 GLN A C   1 
ATOM   2856 O O   . GLN A 1 383 ? 32.216  -42.809 -24.186 1.000 52.110  0 387 GLN A O   1 
ATOM   2857 C CB  . GLN A 1 383 ? 34.196  -40.654 -24.112 1.000 61.540  0 387 GLN A CB  1 
ATOM   2858 C CG  . GLN A 1 383 ? 35.153  -39.579 -24.592 1.000 68.410  0 387 GLN A CG  1 
ATOM   2859 C CD  . GLN A 1 383 ? 36.400  -39.503 -23.747 1.000 80.980  0 387 GLN A CD  1 
ATOM   2860 O OE1 . GLN A 1 383 ? 36.399  -39.903 -22.581 1.000 82.450  0 387 GLN A OE1 1 
ATOM   2861 N NE2 . GLN A 1 383 ? 37.476  -38.982 -24.327 1.000 90.740  0 387 GLN A NE2 1 
ATOM   2862 N N   . TYR A 1 384 ? 30.744  -41.187 -23.674 1.000 49.150  0 388 TYR A N   1 
ATOM   2863 C CA  . TYR A 1 384 ? 29.804  -42.059 -22.994 1.000 43.950  0 388 TYR A CA  1 
ATOM   2864 C C   . TYR A 1 384 ? 28.532  -42.204 -23.818 1.000 47.500  0 388 TYR A C   1 
ATOM   2865 O O   . TYR A 1 384 ? 28.108  -41.272 -24.504 1.000 48.450  0 388 TYR A O   1 
ATOM   2866 C CB  . TYR A 1 384 ? 29.451  -41.506 -21.610 1.000 45.120  0 388 TYR A CB  1 
ATOM   2867 C CG  . TYR A 1 384 ? 30.591  -41.529 -20.616 1.000 48.410  0 388 TYR A CG  1 
ATOM   2868 C CD1 . TYR A 1 384 ? 31.491  -40.474 -20.534 1.000 51.120  0 388 TYR A CD1 1 
ATOM   2869 C CD2 . TYR A 1 384 ? 30.766  -42.607 -19.756 1.000 49.340  0 388 TYR A CD2 1 
ATOM   2870 C CE1 . TYR A 1 384 ? 32.540  -40.497 -19.621 1.000 51.860  0 388 TYR A CE1 1 
ATOM   2871 C CE2 . TYR A 1 384 ? 31.808  -42.634 -18.836 1.000 49.980  0 388 TYR A CE2 1 
ATOM   2872 C CZ  . TYR A 1 384 ? 32.691  -41.579 -18.780 1.000 53.410  0 388 TYR A CZ  1 
ATOM   2873 O OH  . TYR A 1 384 ? 33.722  -41.605 -17.873 1.000 50.920  0 388 TYR A OH  1 
ATOM   2874 N N   . GLN A 1 385 ? 27.912  -43.371 -23.736 1.000 51.030  0 389 GLN A N   1 
ATOM   2875 C CA  . GLN A 1 385 ? 26.594  -43.553 -24.317 1.000 52.940  0 389 GLN A CA  1 
ATOM   2876 C C   . GLN A 1 385 ? 25.539  -43.390 -23.221 1.000 54.140  0 389 GLN A C   1 
ATOM   2877 O O   . GLN A 1 385 ? 25.845  -43.068 -22.068 1.000 46.130  0 389 GLN A O   1 
ATOM   2878 C CB  . GLN A 1 385 ? 26.509  -44.906 -25.022 1.000 51.040  0 389 GLN A CB  1 
ATOM   2879 C CG  . GLN A 1 385 ? 27.630  -45.126 -26.034 1.000 60.870  0 389 GLN A CG  1 
ATOM   2880 C CD  . GLN A 1 385 ? 27.532  -46.464 -26.741 1.000 76.980  0 389 GLN A CD  1 
ATOM   2881 O OE1 . GLN A 1 385 ? 28.056  -47.474 -26.266 1.000 80.450  0 389 GLN A OE1 1 
ATOM   2882 N NE2 . GLN A 1 385 ? 26.865  -46.477 -27.888 1.000 82.720  0 389 GLN A NE2 1 
ATOM   2883 N N   . ASN A 1 386 ? 24.274  -43.598 -23.590 1.000 48.830  0 390 ASN A N   1 
ATOM   2884 C CA  . ASN A 1 386 ? 23.162  -43.429 -22.654 1.000 52.030  0 390 ASN A CA  1 
ATOM   2885 C C   . ASN A 1 386 ? 23.030  -44.693 -21.798 1.000 53.840  0 390 ASN A C   1 
ATOM   2886 O O   . ASN A 1 386 ? 22.082  -45.476 -21.904 1.000 51.180  0 390 ASN A O   1 
ATOM   2887 C CB  . ASN A 1 386 ? 21.880  -43.102 -23.410 1.000 44.840  0 390 ASN A CB  1 
ATOM   2888 C CG  . ASN A 1 386 ? 21.894  -41.697 -24.003 1.000 50.540  0 390 ASN A CG  1 
ATOM   2889 O OD1 . ASN A 1 386 ? 22.645  -40.829 -23.558 1.000 51.050  0 390 ASN A OD1 1 
ATOM   2890 N ND2 . ASN A 1 386 ? 21.079  -41.477 -25.028 1.000 47.630  0 390 ASN A ND2 1 
ATOM   2891 N N   . GLN A 1 387 ? 24.027  -44.883 -20.933 1.000 50.970  0 391 GLN A N   1 
ATOM   2892 C CA  . GLN A 1 387 ? 24.127  -46.051 -20.069 1.000 47.450  0 391 GLN A CA  1 
ATOM   2893 C C   . GLN A 1 387 ? 24.665  -45.623 -18.709 1.000 45.790  0 391 GLN A C   1 
ATOM   2894 O O   . GLN A 1 387 ? 25.024  -44.461 -18.487 1.000 44.340  0 391 GLN A O   1 
ATOM   2895 C CB  . GLN A 1 387 ? 25.041  -47.132 -20.666 1.000 56.000  0 391 GLN A CB  1 
ATOM   2896 C CG  . GLN A 1 387 ? 24.768  -47.507 -22.102 1.000 55.490  0 391 GLN A CG  1 
ATOM   2897 C CD  . GLN A 1 387 ? 25.899  -48.322 -22.706 1.000 60.400  0 391 GLN A CD  1 
ATOM   2898 O OE1 . GLN A 1 387 ? 26.774  -48.821 -21.995 1.000 64.880  0 391 GLN A OE1 1 
ATOM   2899 N NE2 . GLN A 1 387 ? 25.892  -48.451 -24.025 1.000 55.540  0 391 GLN A NE2 1 
ATOM   2900 N N   . VAL A 1 388 ? 24.753  -46.586 -17.799 1.000 42.120  0 392 VAL A N   1 
ATOM   2901 C CA  . VAL A 1 388 ? 25.263  -46.353 -16.458 1.000 38.930  0 392 VAL A CA  1 
ATOM   2902 C C   . VAL A 1 388 ? 26.719  -46.786 -16.418 1.000 39.680  0 392 VAL A C   1 
ATOM   2903 O O   . VAL A 1 388 ? 27.051  -47.896 -16.850 1.000 40.780  0 392 VAL A O   1 
ATOM   2904 C CB  . VAL A 1 388 ? 24.448  -47.116 -15.408 1.000 36.900  0 392 VAL A CB  1 
ATOM   2905 C CG1 . VAL A 1 388 ? 24.989  -46.802 -14.009 1.000 38.570  0 392 VAL A CG1 1 
ATOM   2906 C CG2 . VAL A 1 388 ? 22.950  -46.784 -15.547 1.000 36.840  0 392 VAL A CG2 1 
ATOM   2907 N N   . TYR A 1 389 ? 27.578  -45.920 -15.887 1.000 40.850  0 393 TYR A N   1 
ATOM   2908 C CA  . TYR A 1 389 ? 29.015  -46.170 -15.778 1.000 38.110  0 393 TYR A CA  1 
ATOM   2909 C C   . TYR A 1 389 ? 29.477  -45.914 -14.349 1.000 36.770  0 393 TYR A C   1 
ATOM   2910 O O   . TYR A 1 389 ? 28.791  -45.257 -13.558 1.000 40.310  0 393 TYR A O   1 
ATOM   2911 C CB  . TYR A 1 389 ? 29.824  -45.279 -16.736 1.000 41.820  0 393 TYR A CB  1 
ATOM   2912 C CG  . TYR A 1 389 ? 29.452  -45.420 -18.198 1.000 39.630  0 393 TYR A CG  1 
ATOM   2913 C CD1 . TYR A 1 389 ? 28.389  -44.711 -18.732 1.000 42.590  0 393 TYR A CD1 1 
ATOM   2914 C CD2 . TYR A 1 389 ? 30.161  -46.273 -19.039 1.000 48.690  0 393 TYR A CD2 1 
ATOM   2915 C CE1 . TYR A 1 389 ? 28.040  -44.836 -20.074 1.000 43.000  0 393 TYR A CE1 1 
ATOM   2916 C CE2 . TYR A 1 389 ? 29.818  -46.409 -20.375 1.000 49.100  0 393 TYR A CE2 1 
ATOM   2917 C CZ  . TYR A 1 389 ? 28.759  -45.682 -20.883 1.000 47.250  0 393 TYR A CZ  1 
ATOM   2918 O OH  . TYR A 1 389 ? 28.413  -45.803 -22.200 1.000 45.090  0 393 TYR A OH  1 
ATOM   2919 N N   . VAL A 1 390 ? 30.661  -46.439 -14.015 1.000 36.750  0 394 VAL A N   1 
ATOM   2920 C CA  . VAL A 1 390 ? 31.308  -46.126 -12.748 1.000 37.140  0 394 VAL A CA  1 
ATOM   2921 C C   . VAL A 1 390 ? 32.655  -45.482 -13.050 1.000 41.920  0 394 VAL A C   1 
ATOM   2922 O O   . VAL A 1 390 ? 33.238  -45.680 -14.119 1.000 40.720  0 394 VAL A O   1 
ATOM   2923 C CB  . VAL A 1 390 ? 31.494  -47.363 -11.834 1.000 39.430  0 394 VAL A CB  1 
ATOM   2924 C CG1 . VAL A 1 390 ? 30.133  -47.898 -11.364 1.000 42.720  0 394 VAL A CG1 1 
ATOM   2925 C CG2 . VAL A 1 390 ? 32.313  -48.448 -12.542 1.000 39.720  0 394 VAL A CG2 1 
ATOM   2926 N N   . LEU A 1 391 ? 33.151  -44.703 -12.087 1.000 37.720  0 395 LEU A N   1 
ATOM   2927 C CA  . LEU A 1 391 ? 34.479  -44.119 -12.230 1.000 37.310  0 395 LEU A CA  1 
ATOM   2928 C C   . LEU A 1 391 ? 35.546  -45.209 -12.121 1.000 39.940  0 395 LEU A C   1 
ATOM   2929 O O   . LEU A 1 391 ? 35.351  -46.211 -11.430 1.000 37.920  0 395 LEU A O   1 
ATOM   2930 C CB  . LEU A 1 391 ? 34.715  -43.052 -11.163 1.000 40.660  0 395 LEU A CB  1 
ATOM   2931 C CG  . LEU A 1 391 ? 33.785  -41.832 -11.216 1.000 43.200  0 395 LEU A CG  1 
ATOM   2932 C CD1 . LEU A 1 391 ? 33.958  -40.948 -9.973  1.000 43.690  0 395 LEU A CD1 1 
ATOM   2933 C CD2 . LEU A 1 391 ? 34.030  -41.023 -12.489 1.000 43.010  0 395 LEU A CD2 1 
ATOM   2934 N N   . PRO A 1 392 ? 36.680  -45.035 -12.794 1.000 39.220  0 396 PRO A N   1 
ATOM   2935 C CA  . PRO A 1 392 ? 37.726  -46.062 -12.761 1.000 42.740  0 396 PRO A CA  1 
ATOM   2936 C C   . PRO A 1 392 ? 38.357  -46.198 -11.384 1.000 42.670  0 396 PRO A C   1 
ATOM   2937 O O   . PRO A 1 392 ? 38.288  -45.305 -10.536 1.000 37.750  0 396 PRO A O   1 
ATOM   2938 C CB  . PRO A 1 392 ? 38.746  -45.567 -13.792 1.000 44.160  0 396 PRO A CB  1 
ATOM   2939 C CG  . PRO A 1 392 ? 38.460  -44.121 -13.956 1.000 49.030  0 396 PRO A CG  1 
ATOM   2940 C CD  . PRO A 1 392 ? 36.986  -43.969 -13.760 1.000 40.820  0 396 PRO A CD  1 
ATOM   2941 N N   . LYS A 1 393 ? 38.996  -47.354 -11.176 1.000 39.120  0 397 LYS A N   1 
ATOM   2942 C CA  . LYS A 1 393 ? 39.525  -47.678 -9.857  1.000 37.500  0 397 LYS A CA  1 
ATOM   2943 C C   . LYS A 1 393 ? 40.628  -46.712 -9.433  1.000 34.100  0 397 LYS A C   1 
ATOM   2944 O O   . LYS A 1 393 ? 40.821  -46.494 -8.230  1.000 37.310  0 397 LYS A O   1 
ATOM   2945 C CB  . LYS A 1 393 ? 40.043  -49.120 -9.842  1.000 38.430  0 397 LYS A CB  1 
ATOM   2946 C CG  . LYS A 1 393 ? 40.509  -49.621 -8.470  1.000 36.040  0 397 LYS A CG  1 
ATOM   2947 C CD  . LYS A 1 393 ? 40.795  -51.129 -8.501  1.000 36.100  0 397 LYS A CD  1 
ATOM   2948 C CE  . LYS A 1 393 ? 39.488  -51.935 -8.650  1.000 37.490  0 397 LYS A CE  1 
ATOM   2949 N NZ  . LYS A 1 393 ? 38.491  -51.590 -7.579  1.000 37.350  0 397 LYS A NZ  1 
ATOM   2950 N N   . VAL A 1 394 ? 41.366  -46.134 -10.388 1.000 33.160  0 398 VAL A N   1 
ATOM   2951 C CA  . VAL A 1 394 ? 42.442  -45.213 -10.002 1.000 37.860  0 398 VAL A CA  1 
ATOM   2952 C C   . VAL A 1 394 ? 41.869  -44.008 -9.264  1.000 43.020  0 398 VAL A C   1 
ATOM   2953 O O   . VAL A 1 394 ? 42.468  -43.512 -8.302  1.000 36.000  0 398 VAL A O   1 
ATOM   2954 C CB  . VAL A 1 394 ? 43.291  -44.784 -11.216 1.000 48.250  0 398 VAL A CB  1 
ATOM   2955 C CG1 . VAL A 1 394 ? 44.204  -45.911 -11.653 1.000 49.060  0 398 VAL A CG1 1 
ATOM   2956 C CG2 . VAL A 1 394 ? 42.424  -44.299 -12.364 1.000 46.180  0 398 VAL A CG2 1 
ATOM   2957 N N   . LEU A 1 395 ? 40.687  -43.535 -9.680  1.000 39.510  0 399 LEU A N   1 
ATOM   2958 C CA  . LEU A 1 395 ? 40.049  -42.420 -8.977  1.000 37.920  0 399 LEU A CA  1 
ATOM   2959 C C   . LEU A 1 395 ? 39.488  -42.858 -7.629  1.000 38.550  0 399 LEU A C   1 
ATOM   2960 O O   . LEU A 1 395 ? 39.508  -42.091 -6.661  1.000 41.100  0 399 LEU A O   1 
ATOM   2961 C CB  . LEU A 1 395 ? 38.935  -41.817 -9.836  1.000 38.850  0 399 LEU A CB  1 
ATOM   2962 C CG  . LEU A 1 395 ? 39.371  -41.058 -11.091 1.000 45.740  0 399 LEU A CG  1 
ATOM   2963 C CD1 . LEU A 1 395 ? 38.159  -40.386 -11.713 1.000 42.930  0 399 LEU A CD1 1 
ATOM   2964 C CD2 . LEU A 1 395 ? 40.451  -40.044 -10.764 1.000 41.290  0 399 LEU A CD2 1 
ATOM   2965 N N   . ASP A 1 396 ? 38.921  -44.065 -7.566  1.000 34.000  0 400 ASP A N   1 
ATOM   2966 C CA  . ASP A 1 396 ? 38.468  -44.620 -6.293  1.000 35.710  0 400 ASP A CA  1 
ATOM   2967 C C   . ASP A 1 396 ? 39.620  -44.671 -5.284  1.000 37.770  0 400 ASP A C   1 
ATOM   2968 O O   . ASP A 1 396 ? 39.470  -44.267 -4.122  1.000 34.910  0 400 ASP A O   1 
ATOM   2969 C CB  . ASP A 1 396 ? 37.882  -46.013 -6.556  1.000 29.040  0 400 ASP A CB  1 
ATOM   2970 C CG  . ASP A 1 396 ? 36.731  -46.381 -5.626  1.000 33.560  0 400 ASP A CG  1 
ATOM   2971 O OD1 . ASP A 1 396 ? 36.484  -45.691 -4.610  1.000 36.750  0 400 ASP A OD1 1 
ATOM   2972 O OD2 . ASP A 1 396 ? 36.073  -47.408 -5.921  1.000 36.500  0 400 ASP A OD2 1 
ATOM   2973 N N   . GLU A 1 397 ? 40.790  -45.151 -5.720  1.000 31.520  0 401 GLU A N   1 
ATOM   2974 C CA  . GLU A 1 397 ? 41.956  -45.196 -4.837  1.000 35.320  0 401 GLU A CA  1 
ATOM   2975 C C   . GLU A 1 397 ? 42.415  -43.792 -4.450  1.000 32.570  0 401 GLU A C   1 
ATOM   2976 O O   . GLU A 1 397 ? 42.840  -43.561 -3.309  1.000 35.080  0 401 GLU A O   1 
ATOM   2977 C CB  . GLU A 1 397 ? 43.090  -45.979 -5.510  1.000 38.400  0 401 GLU A CB  1 
ATOM   2978 C CG  . GLU A 1 397 ? 42.763  -47.491 -5.641  1.000 34.500  0 401 GLU A CG  1 
ATOM   2979 C CD  . GLU A 1 397 ? 43.862  -48.294 -6.324  1.000 42.050  0 401 GLU A CD  1 
ATOM   2980 O OE1 . GLU A 1 397 ? 43.767  -49.543 -6.338  1.000 37.320  0 401 GLU A OE1 1 
ATOM   2981 O OE2 . GLU A 1 397 ? 44.815  -47.679 -6.848  1.000 43.160  0 401 GLU A OE2 1 
ATOM   2982 N N   . LYS A 1 398 ? 42.351  -42.843 -5.385  1.000 34.700  0 402 LYS A N   1 
ATOM   2983 C CA  . LYS A 1 398 ? 42.691  -41.460 -5.043  1.000 36.990  0 402 LYS A CA  1 
ATOM   2984 C C   . LYS A 1 398 ? 41.791  -40.921 -3.935  1.000 33.790  0 402 LYS A C   1 
ATOM   2985 O O   . LYS A 1 398 ? 42.264  -40.231 -3.021  1.000 34.360  0 402 LYS A O   1 
ATOM   2986 C CB  . LYS A 1 398 ? 42.601  -40.566 -6.282  1.000 37.350  0 402 LYS A CB  1 
ATOM   2987 C CG  . LYS A 1 398 ? 42.676  -39.066 -5.970  1.000 42.870  0 402 LYS A CG  1 
ATOM   2988 C CD  . LYS A 1 398 ? 42.635  -38.237 -7.242  1.000 49.960  0 402 LYS A CD  1 
ATOM   2989 C CE  . LYS A 1 398 ? 42.940  -36.770 -6.958  1.000 53.270  0 402 LYS A CE  1 
ATOM   2990 N NZ  . LYS A 1 398 ? 43.421  -36.056 -8.174  1.000 46.230  0 402 LYS A NZ  1 
ATOM   2991 N N   . VAL A 1 399 ? 40.487  -41.214 -3.998  1.000 36.320  0 403 VAL A N   1 
ATOM   2992 C CA  . VAL A 1 399 ? 39.578  -40.761 -2.946  1.000 37.870  0 403 VAL A CA  1 
ATOM   2993 C C   . VAL A 1 399 ? 40.035  -41.289 -1.592  1.000 37.680  0 403 VAL A C   1 
ATOM   2994 O O   . VAL A 1 399 ? 40.143  -40.534 -0.621  1.000 35.220  0 403 VAL A O   1 
ATOM   2995 C CB  . VAL A 1 399 ? 38.126  -41.181 -3.247  1.000 35.680  0 403 VAL A CB  1 
ATOM   2996 C CG1 . VAL A 1 399 ? 37.244  -40.860 -2.059  1.000 33.480  0 403 VAL A CG1 1 
ATOM   2997 C CG2 . VAL A 1 399 ? 37.609  -40.472 -4.479  1.000 37.800  0 403 VAL A CG2 1 
ATOM   2998 N N   . ALA A 1 400 ? 40.319  -42.595 -1.510  1.000 35.400  0 404 ALA A N   1 
ATOM   2999 C CA  . ALA A 1 400 ? 40.782  -43.170 -0.248  1.000 35.220  0 404 ALA A CA  1 
ATOM   3000 C C   . ALA A 1 400 ? 42.083  -42.519 0.198   1.000 36.280  0 404 ALA A C   1 
ATOM   3001 O O   . ALA A 1 400 ? 42.234  -42.137 1.365   1.000 33.650  0 404 ALA A O   1 
ATOM   3002 C CB  . ALA A 1 400 ? 40.968  -44.683 -0.387  1.000 36.020  0 404 ALA A CB  1 
ATOM   3003 N N   . ARG A 1 401 ? 43.041  -42.395 -0.729  1.000 35.720  0 405 ARG A N   1 
ATOM   3004 C CA  . ARG A 1 401 ? 44.320  -41.763 -0.420  1.000 36.730  0 405 ARG A CA  1 
ATOM   3005 C C   . ARG A 1 401 ? 44.124  -40.392 0.209   1.000 44.240  0 405 ARG A C   1 
ATOM   3006 O O   . ARG A 1 401 ? 44.798  -40.043 1.187   1.000 37.230  0 405 ARG A O   1 
ATOM   3007 C CB  . ARG A 1 401 ? 45.146  -41.638 -1.704  1.000 42.690  0 405 ARG A CB  1 
ATOM   3008 C CG  . ARG A 1 401 ? 46.561  -42.133 -1.626  1.000 62.940  0 405 ARG A CG  1 
ATOM   3009 C CD  . ARG A 1 401 ? 47.244  -41.953 -2.978  1.000 53.270  0 405 ARG A CD  1 
ATOM   3010 N NE  . ARG A 1 401 ? 47.299  -43.193 -3.758  1.000 54.370  0 405 ARG A NE  1 
ATOM   3011 C CZ  . ARG A 1 401 ? 48.232  -44.130 -3.594  1.000 56.850  0 405 ARG A CZ  1 
ATOM   3012 N NH1 . ARG A 1 401 ? 49.173  -43.975 -2.671  1.000 57.420  0 405 ARG A NH1 1 
ATOM   3013 N NH2 . ARG A 1 401 ? 48.234  -45.219 -4.353  1.000 51.570  0 405 ARG A NH2 1 
ATOM   3014 N N   . LEU A 1 402 ? 43.215  -39.585 -0.348  1.000 40.270  0 406 LEU A N   1 
ATOM   3015 C CA  . LEU A 1 402 ? 43.041  -38.236 0.179   1.000 33.950  0 406 LEU A CA  1 
ATOM   3016 C C   . LEU A 1 402 ? 42.490  -38.216 1.598   1.000 37.840  0 406 LEU A C   1 
ATOM   3017 O O   . LEU A 1 402 ? 42.523  -37.156 2.229   1.000 37.380  0 406 LEU A O   1 
ATOM   3018 C CB  . LEU A 1 402 ? 42.114  -37.414 -0.734  1.000 37.000  0 406 LEU A CB  1 
ATOM   3019 C CG  . LEU A 1 402 ? 42.663  -37.144 -2.141  1.000 43.050  0 406 LEU A CG  1 
ATOM   3020 C CD1 . LEU A 1 402 ? 41.561  -36.652 -3.098  1.000 37.150  0 406 LEU A CD1 1 
ATOM   3021 C CD2 . LEU A 1 402 ? 43.815  -36.165 -2.072  1.000 43.340  0 406 LEU A CD2 1 
ATOM   3022 N N   . HIS A 1 403 ? 41.957  -39.333 2.106   1.000 33.550  0 407 HIS A N   1 
ATOM   3023 C CA  . HIS A 1 403 ? 41.356  -39.350 3.436   1.000 35.790  0 407 HIS A CA  1 
ATOM   3024 C C   . HIS A 1 403 ? 42.225  -40.040 4.480   1.000 38.940  0 407 HIS A C   1 
ATOM   3025 O O   . HIS A 1 403 ? 41.875  -40.038 5.665   1.000 38.910  0 407 HIS A O   1 
ATOM   3026 C CB  . HIS A 1 403 ? 39.953  -40.001 3.364   1.000 34.480  0 407 HIS A CB  1 
ATOM   3027 C CG  . HIS A 1 403 ? 38.960  -39.167 2.609   1.000 33.460  0 407 HIS A CG  1 
ATOM   3028 N ND1 . HIS A 1 403 ? 38.876  -39.174 1.232   1.000 33.220  0 407 HIS A ND1 1 
ATOM   3029 C CD2 . HIS A 1 403 ? 38.065  -38.244 3.033   1.000 33.480  0 407 HIS A CD2 1 
ATOM   3030 C CE1 . HIS A 1 403 ? 37.947  -38.317 0.842   1.000 32.040  0 407 HIS A CE1 1 
ATOM   3031 N NE2 . HIS A 1 403 ? 37.441  -37.737 1.916   1.000 36.150  0 407 HIS A NE2 1 
ATOM   3032 N N   . LEU A 1 404 ? 43.365  -40.601 4.077   1.000 36.330  0 408 LEU A N   1 
ATOM   3033 C CA  . LEU A 1 404 ? 44.181  -41.370 5.003   1.000 31.840  0 408 LEU A CA  1 
ATOM   3034 C C   . LEU A 1 404 ? 44.867  -40.467 6.020   1.000 38.850  0 408 LEU A C   1 
ATOM   3035 O O   . LEU A 1 404 ? 44.989  -40.832 7.193   1.000 41.670  0 408 LEU A O   1 
ATOM   3036 C CB  . LEU A 1 404 ? 45.221  -42.178 4.229   1.000 37.400  0 408 LEU A CB  1 
ATOM   3037 C CG  . LEU A 1 404 ? 44.749  -43.352 3.360   1.000 38.940  0 408 LEU A CG  1 
ATOM   3038 C CD1 . LEU A 1 404 ? 45.971  -43.929 2.631   1.000 34.860  0 408 LEU A CD1 1 
ATOM   3039 C CD2 . LEU A 1 404 ? 44.071  -44.406 4.208   1.000 38.680  0 408 LEU A CD2 1 
ATOM   3040 N N   . GLY A 1 405 ? 45.328  -39.294 5.584   1.000 38.630  0 409 GLY A N   1 
ATOM   3041 C CA  . GLY A 1 405 ? 46.079  -38.423 6.475   1.000 41.730  0 409 GLY A CA  1 
ATOM   3042 C C   . GLY A 1 405 ? 45.269  -37.990 7.680   1.000 46.640  0 409 GLY A C   1 
ATOM   3043 O O   . GLY A 1 405 ? 45.787  -37.936 8.797   1.000 42.080  0 409 GLY A O   1 
ATOM   3044 N N   . ARG A 1 406 ? 43.980  -37.699 7.475   1.000 38.830  0 410 ARG A N   1 
ATOM   3045 C CA  . ARG A 1 406 ? 43.160  -37.157 8.559   1.000 41.920  0 410 ARG A CA  1 
ATOM   3046 C C   . ARG A 1 406 ? 43.097  -38.117 9.737   1.000 37.910  0 410 ARG A C   1 
ATOM   3047 O O   . ARG A 1 406 ? 43.163  -37.694 10.896  1.000 45.440  0 410 ARG A O   1 
ATOM   3048 C CB  . ARG A 1 406 ? 41.741  -36.853 8.070   1.000 47.390  0 410 ARG A CB  1 
ATOM   3049 C CG  . ARG A 1 406 ? 40.743  -36.485 9.208   1.000 45.170  0 410 ARG A CG  1 
ATOM   3050 C CD  . ARG A 1 406 ? 41.191  -35.191 9.919   1.000 49.220  0 410 ARG A CD  1 
ATOM   3051 N NE  . ARG A 1 406 ? 40.435  -34.871 11.136  1.000 53.520  0 410 ARG A NE  1 
ATOM   3052 C CZ  . ARG A 1 406 ? 40.704  -35.363 12.347  1.000 55.460  0 410 ARG A CZ  1 
ATOM   3053 N NH1 . ARG A 1 406 ? 41.705  -36.226 12.518  1.000 46.740  0 410 ARG A NH1 1 
ATOM   3054 N NH2 . ARG A 1 406 ? 39.969  -34.993 13.393  1.000 45.280  0 410 ARG A NH2 1 
ATOM   3055 N N   . ILE A 1 407 ? 42.975  -39.409 9.463   1.000 35.080  0 411 ILE A N   1 
ATOM   3056 C CA  . ILE A 1 407 ? 42.847  -40.392 10.514  1.000 33.720  0 411 ILE A CA  1 
ATOM   3057 C C   . ILE A 1 407 ? 44.175  -41.105 10.780  1.000 42.660  0 411 ILE A C   1 
ATOM   3058 O O   . ILE A 1 407 ? 44.188  -42.167 11.399  1.000 41.560  0 411 ILE A O   1 
ATOM   3059 C CB  . ILE A 1 407 ? 41.712  -41.381 10.220  1.000 44.550  0 411 ILE A CB  1 
ATOM   3060 C CG1 . ILE A 1 407 ? 41.866  -41.987 8.832   1.000 45.730  0 411 ILE A CG1 1 
ATOM   3061 C CG2 . ILE A 1 407 ? 40.365  -40.656 10.323  1.000 44.400  0 411 ILE A CG2 1 
ATOM   3062 C CD1 . ILE A 1 407 ? 40.665  -42.756 8.421   1.000 49.300  0 411 ILE A CD1 1 
ATOM   3063 N N   . GLY A 1 408 ? 45.288  -40.522 10.330  1.000 41.910  0 412 GLY A N   1 
ATOM   3064 C CA  . GLY A 1 408 ? 46.623  -40.964 10.704  1.000 44.620  0 412 GLY A CA  1 
ATOM   3065 C C   . GLY A 1 408 ? 47.037  -42.332 10.207  1.000 45.160  0 412 GLY A C   1 
ATOM   3066 O O   . GLY A 1 408 ? 47.847  -42.997 10.859  1.000 48.500  0 412 GLY A O   1 
ATOM   3067 N N   . ALA A 1 409 ? 46.507  -42.780 9.075   1.000 36.810  0 413 ALA A N   1 
ATOM   3068 C CA  . ALA A 1 409 ? 46.864  -44.085 8.526   1.000 30.460  0 413 ALA A CA  1 
ATOM   3069 C C   . ALA A 1 409 ? 48.071  -43.932 7.602   1.000 38.540  0 413 ALA A C   1 
ATOM   3070 O O   . ALA A 1 409 ? 48.107  -43.014 6.777   1.000 42.530  0 413 ALA A O   1 
ATOM   3071 C CB  . ALA A 1 409 ? 45.673  -44.687 7.774   1.000 36.890  0 413 ALA A CB  1 
ATOM   3072 N N   . LYS A 1 410 ? 49.069  -44.807 7.763   1.000 33.780  0 414 LYS A N   1 
ATOM   3073 C CA  . LYS A 1 410 ? 50.332  -44.719 7.024   1.000 33.810  0 414 LYS A CA  1 
ATOM   3074 C C   . LYS A 1 410 ? 50.439  -45.893 6.063   1.000 38.260  0 414 LYS A C   1 
ATOM   3075 O O   . LYS A 1 410 ? 50.488  -47.051 6.492   1.000 36.570  0 414 LYS A O   1 
ATOM   3076 C CB  . LYS A 1 410 ? 51.546  -44.704 7.960   1.000 41.130  0 414 LYS A CB  1 
ATOM   3077 C CG  . LYS A 1 410 ? 52.890  -44.582 7.215   1.000 38.920  0 414 LYS A CG  1 
ATOM   3078 C CD  . LYS A 1 410 ? 54.046  -44.379 8.189   1.000 42.520  0 414 LYS A CD  1 
ATOM   3079 C CE  . LYS A 1 410 ? 55.364  -44.120 7.465   1.000 47.720  0 414 LYS A CE  1 
ATOM   3080 N NZ  . LYS A 1 410 ? 56.436  -43.819 8.458   1.000 38.070  0 414 LYS A NZ  1 
ATOM   3081 N N   . LEU A 1 411 ? 50.486  -45.589 4.770   1.000 32.240  0 415 LEU A N   1 
ATOM   3082 C CA  . LEU A 1 411 ? 50.535  -46.620 3.739   1.000 40.090  0 415 LEU A CA  1 
ATOM   3083 C C   . LEU A 1 411 ? 51.942  -47.192 3.582   1.000 41.560  0 415 LEU A C   1 
ATOM   3084 O O   . LEU A 1 411 ? 52.932  -46.454 3.562   1.000 36.240  0 415 LEU A O   1 
ATOM   3085 C CB  . LEU A 1 411 ? 50.070  -46.023 2.411   1.000 49.180  0 415 LEU A CB  1 
ATOM   3086 C CG  . LEU A 1 411 ? 49.121  -46.732 1.450   1.000 44.960  0 415 LEU A CG  1 
ATOM   3087 C CD1 . LEU A 1 411 ? 47.889  -47.349 2.153   1.000 40.580  0 415 LEU A CD1 1 
ATOM   3088 C CD2 . LEU A 1 411 ? 48.717  -45.735 0.350   1.000 41.960  0 415 LEU A CD2 1 
ATOM   3089 N N   . THR A 1 412 ? 52.022  -48.514 3.452   1.000 34.340  0 416 THR A N   1 
ATOM   3090 C CA  . THR A 1 412 ? 53.252  -49.190 3.048   1.000 32.950  0 416 THR A CA  1 
ATOM   3091 C C   . THR A 1 412 ? 53.458  -49.020 1.541   1.000 35.430  0 416 THR A C   1 
ATOM   3092 O O   . THR A 1 412 ? 52.493  -49.009 0.773   1.000 38.830  0 416 THR A O   1 
ATOM   3093 C CB  . THR A 1 412 ? 53.156  -50.680 3.431   1.000 34.580  0 416 THR A CB  1 
ATOM   3094 O OG1 . THR A 1 412 ? 53.093  -50.806 4.857   1.000 36.810  0 416 THR A OG1 1 
ATOM   3095 C CG2 . THR A 1 412 ? 54.347  -51.513 2.915   1.000 31.190  0 416 THR A CG2 1 
ATOM   3096 N N   . GLN A 1 413 ? 54.715  -48.852 1.111   1.000 33.940  0 417 GLN A N   1 
ATOM   3097 C CA  . GLN A 1 413 ? 55.025  -48.717 -0.311  1.000 33.750  0 417 GLN A CA  1 
ATOM   3098 C C   . GLN A 1 413 ? 55.563  -50.037 -0.849  1.000 37.940  0 417 GLN A C   1 
ATOM   3099 O O   . GLN A 1 413 ? 56.481  -50.626 -0.262  1.000 38.590  0 417 GLN A O   1 
ATOM   3100 C CB  . GLN A 1 413 ? 56.048  -47.600 -0.561  1.000 42.480  0 417 GLN A CB  1 
ATOM   3101 C CG  . GLN A 1 413 ? 55.805  -46.327 0.254   1.000 53.210  0 417 GLN A CG  1 
ATOM   3102 C CD  . GLN A 1 413 ? 54.925  -45.309 -0.452  1.000 69.690  0 417 GLN A CD  1 
ATOM   3103 O OE1 . GLN A 1 413 ? 53.690  -45.330 -0.335  1.000 60.920  0 417 GLN A OE1 1 
ATOM   3104 N NE2 . GLN A 1 413 ? 55.561  -44.389 -1.174  1.000 83.830  0 417 GLN A NE2 1 
ATOM   3105 N N   . LEU A 1 414 ? 55.000  -50.499 -1.962  1.000 35.080  0 418 LEU A N   1 
ATOM   3106 C CA  . LEU A 1 414 ? 55.522  -51.708 -2.592  1.000 32.890  0 418 LEU A CA  1 
ATOM   3107 C C   . LEU A 1 414 ? 56.937  -51.462 -3.100  1.000 39.320  0 418 LEU A C   1 
ATOM   3108 O O   . LEU A 1 414 ? 57.229  -50.401 -3.660  1.000 35.300  0 418 LEU A O   1 
ATOM   3109 C CB  . LEU A 1 414 ? 54.643  -52.136 -3.764  1.000 36.130  0 418 LEU A CB  1 
ATOM   3110 C CG  . LEU A 1 414 ? 53.222  -52.631 -3.481  1.000 35.130  0 418 LEU A CG  1 
ATOM   3111 C CD1 . LEU A 1 414 ? 52.417  -52.527 -4.779  1.000 33.150  0 418 LEU A CD1 1 
ATOM   3112 C CD2 . LEU A 1 414 ? 53.265  -54.076 -2.925  1.000 31.130  0 418 LEU A CD2 1 
ATOM   3113 N N   . SER A 1 415 ? 57.815  -52.452 -2.916  1.000 35.030  0 419 SER A N   1 
ATOM   3114 C CA  . SER A 1 415 ? 59.051  -52.482 -3.690  1.000 36.590  0 419 SER A CA  1 
ATOM   3115 C C   . SER A 1 415 ? 58.753  -52.910 -5.126  1.000 40.960  0 419 SER A C   1 
ATOM   3116 O O   . SER A 1 415 ? 57.664  -53.391 -5.444  1.000 34.860  0 419 SER A O   1 
ATOM   3117 C CB  . SER A 1 415 ? 60.059  -53.457 -3.081  1.000 39.260  0 419 SER A CB  1 
ATOM   3118 O OG  . SER A 1 415 ? 59.531  -54.779 -3.097  1.000 36.110  0 419 SER A OG  1 
ATOM   3119 N N   . ASN A 1 416 ? 59.759  -52.778 -5.993  1.000 39.170  0 420 ASN A N   1 
ATOM   3120 C CA  . ASN A 1 416 ? 59.592  -53.192 -7.387  1.000 43.410  0 420 ASN A CA  1 
ATOM   3121 C C   . ASN A 1 416 ? 59.267  -54.676 -7.492  1.000 40.330  0 420 ASN A C   1 
ATOM   3122 O O   . ASN A 1 416 ? 58.392  -55.072 -8.270  1.000 35.660  0 420 ASN A O   1 
ATOM   3123 C CB  . ASN A 1 416 ? 60.858  -52.894 -8.198  1.000 43.860  0 420 ASN A CB  1 
ATOM   3124 C CG  . ASN A 1 416 ? 61.087  -51.418 -8.401  1.000 47.220  0 420 ASN A CG  1 
ATOM   3125 O OD1 . ASN A 1 416 ? 60.151  -50.653 -8.610  1.000 45.820  0 420 ASN A OD1 1 
ATOM   3126 N ND2 . ASN A 1 416 ? 62.337  -51.011 -8.350  1.000 50.570  0 420 ASN A ND2 1 
ATOM   3127 N N   . GLU A 1 417 ? 59.977  -55.520 -6.731  1.000 35.490  0 421 GLU A N   1 
ATOM   3128 C CA  . GLU A 1 417 ? 59.726  -56.955 -6.827  1.000 39.330  0 421 GLU A CA  1 
ATOM   3129 C C   . GLU A 1 417 ? 58.363  -57.317 -6.244  1.000 37.110  0 421 GLU A C   1 
ATOM   3130 O O   . GLU A 1 417 ? 57.718  -58.260 -6.721  1.000 37.400  0 421 GLU A O   1 
ATOM   3131 C CB  . GLU A 1 417 ? 60.852  -57.744 -6.132  1.000 36.680  0 421 GLU A CB  1 
ATOM   3132 C CG  . GLU A 1 417 ? 60.924  -57.542 -4.594  1.000 34.580  0 421 GLU A CG  1 
ATOM   3133 C CD  . GLU A 1 417 ? 62.030  -58.373 -3.932  1.000 36.050  0 421 GLU A CD  1 
ATOM   3134 O OE1 . GLU A 1 417 ? 62.935  -58.843 -4.640  1.000 41.600  0 421 GLU A OE1 1 
ATOM   3135 O OE2 . GLU A 1 417 ? 61.976  -58.553 -2.697  1.000 40.730  0 421 GLU A OE2 1 
ATOM   3136 N N   . GLN A 1 418 ? 57.900  -56.571 -5.236  1.000 31.790  0 422 GLN A N   1 
ATOM   3137 C CA  . GLN A 1 418 ? 56.582  -56.829 -4.661  1.000 33.340  0 422 GLN A CA  1 
ATOM   3138 C C   . GLN A 1 418 ? 55.462  -56.429 -5.612  1.000 41.650  0 422 GLN A C   1 
ATOM   3139 O O   . GLN A 1 418 ? 54.441  -57.119 -5.692  1.000 36.270  0 422 GLN A O   1 
ATOM   3140 C CB  . GLN A 1 418 ? 56.431  -56.093 -3.329  1.000 32.460  0 422 GLN A CB  1 
ATOM   3141 C CG  . GLN A 1 418 ? 57.211  -56.748 -2.215  1.000 35.910  0 422 GLN A CG  1 
ATOM   3142 C CD  . GLN A 1 418 ? 57.216  -55.915 -0.964  1.000 40.960  0 422 GLN A CD  1 
ATOM   3143 O OE1 . GLN A 1 418 ? 56.990  -54.700 -1.011  1.000 37.600  0 422 GLN A OE1 1 
ATOM   3144 N NE2 . GLN A 1 418 ? 57.468  -56.557 0.168   1.000 37.470  0 422 GLN A NE2 1 
ATOM   3145 N N   . ALA A 1 419 ? 55.618  -55.309 -6.326  1.000 34.880  0 423 ALA A N   1 
ATOM   3146 C CA  . ALA A 1 419 ? 54.617  -54.938 -7.328  1.000 39.440  0 423 ALA A CA  1 
ATOM   3147 C C   . ALA A 1 419 ? 54.543  -55.986 -8.434  1.000 37.360  0 423 ALA A C   1 
ATOM   3148 O O   . ALA A 1 419 ? 53.453  -56.398 -8.858  1.000 38.840  0 423 ALA A O   1 
ATOM   3149 C CB  . ALA A 1 419 ? 54.948  -53.565 -7.913  1.000 36.020  0 423 ALA A CB  1 
ATOM   3150 N N   . ASP A 1 420 ? 55.708  -56.437 -8.904  1.000 40.120  0 424 ASP A N   1 
ATOM   3151 C CA  . ASP A 1 420 ? 55.760  -57.479 -9.923  1.000 37.950  0 424 ASP A CA  1 
ATOM   3152 C C   . ASP A 1 420 ? 55.176  -58.784 -9.416  1.000 32.800  0 424 ASP A C   1 
ATOM   3153 O O   . ASP A 1 420 ? 54.483  -59.489 -10.160 1.000 42.410  0 424 ASP A O   1 
ATOM   3154 C CB  . ASP A 1 420 ? 57.200  -57.695 -10.376 1.000 36.040  0 424 ASP A CB  1 
ATOM   3155 C CG  . ASP A 1 420 ? 57.718  -56.543 -11.194 1.000 49.270  0 424 ASP A CG  1 
ATOM   3156 O OD1 . ASP A 1 420 ? 56.891  -55.716 -11.634 1.000 44.230  0 424 ASP A OD1 1 
ATOM   3157 O OD2 . ASP A 1 420 ? 58.940  -56.462 -11.387 1.000 43.580  0 424 ASP A OD2 1 
ATOM   3158 N N   . TYR A 1 421 ? 55.424  -59.109 -8.145  1.000 34.620  0 425 TYR A N   1 
ATOM   3159 C CA  . TYR A 1 421 ? 54.995  -60.396 -7.612  1.000 40.540  0 425 TYR A CA  1 
ATOM   3160 C C   . TYR A 1 421 ? 53.478  -60.556 -7.679  1.000 39.730  0 425 TYR A C   1 
ATOM   3161 O O   . TYR A 1 421 ? 52.977  -61.633 -8.024  1.000 34.680  0 425 TYR A O   1 
ATOM   3162 C CB  . TYR A 1 421 ? 55.479  -60.556 -6.172  1.000 33.730  0 425 TYR A CB  1 
ATOM   3163 C CG  . TYR A 1 421 ? 55.316  -61.967 -5.629  1.000 33.230  0 425 TYR A CG  1 
ATOM   3164 C CD1 . TYR A 1 421 ? 56.290  -62.941 -5.861  1.000 36.930  0 425 TYR A CD1 1 
ATOM   3165 C CD2 . TYR A 1 421 ? 54.193  -62.321 -4.879  1.000 37.660  0 425 TYR A CD2 1 
ATOM   3166 C CE1 . TYR A 1 421 ? 56.146  -64.228 -5.356  1.000 44.620  0 425 TYR A CE1 1 
ATOM   3167 C CE2 . TYR A 1 421 ? 54.044  -63.593 -4.372  1.000 38.520  0 425 TYR A CE2 1 
ATOM   3168 C CZ  . TYR A 1 421 ? 55.025  -64.544 -4.611  1.000 46.040  0 425 TYR A CZ  1 
ATOM   3169 O OH  . TYR A 1 421 ? 54.875  -65.809 -4.102  1.000 48.120  0 425 TYR A OH  1 
ATOM   3170 N N   . ILE A 1 422 ? 52.728  -59.500 -7.350  1.000 37.920  0 426 ILE A N   1 
ATOM   3171 C CA  . ILE A 1 422 ? 51.268  -59.576 -7.401  1.000 38.500  0 426 ILE A CA  1 
ATOM   3172 C C   . ILE A 1 422 ? 50.690  -58.959 -8.663  1.000 43.110  0 426 ILE A C   1 
ATOM   3173 O O   . ILE A 1 422 ? 49.459  -58.899 -8.804  1.000 40.630  0 426 ILE A O   1 
ATOM   3174 C CB  . ILE A 1 422 ? 50.616  -58.940 -6.155  1.000 37.920  0 426 ILE A CB  1 
ATOM   3175 C CG1 . ILE A 1 422 ? 51.003  -57.459 -6.016  1.000 32.220  0 426 ILE A CG1 1 
ATOM   3176 C CG2 . ILE A 1 422 ? 50.980  -59.736 -4.909  1.000 36.520  0 426 ILE A CG2 1 
ATOM   3177 C CD1 . ILE A 1 422 ? 50.238  -56.725 -4.896  1.000 32.740  0 426 ILE A CD1 1 
ATOM   3178 N N   . GLY A 1 423 ? 51.531  -58.494 -9.579  1.000 37.420  0 427 GLY A N   1 
ATOM   3179 C CA  . GLY A 1 423 ? 51.071  -58.063 -10.885 1.000 40.130  0 427 GLY A CA  1 
ATOM   3180 C C   . GLY A 1 423 ? 50.425  -56.698 -10.914 1.000 48.690  0 427 GLY A C   1 
ATOM   3181 O O   . GLY A 1 423 ? 49.446  -56.495 -11.643 1.000 44.990  0 427 GLY A O   1 
ATOM   3182 N N   . VAL A 1 424 ? 50.948  -55.744 -10.144 1.000 41.840  0 428 VAL A N   1 
ATOM   3183 C CA  . VAL A 1 424 ? 50.373  -54.410 -10.076 1.000 38.390  0 428 VAL A CA  1 
ATOM   3184 C C   . VAL A 1 424 ? 51.476  -53.387 -10.292 1.000 44.850  0 428 VAL A C   1 
ATOM   3185 O O   . VAL A 1 424 ? 52.667  -53.666 -10.123 1.000 40.270  0 428 VAL A O   1 
ATOM   3186 C CB  . VAL A 1 424 ? 49.663  -54.121 -8.734  1.000 41.320  0 428 VAL A CB  1 
ATOM   3187 C CG1 . VAL A 1 424 ? 48.527  -55.152 -8.445  1.000 38.810  0 428 VAL A CG1 1 
ATOM   3188 C CG2 . VAL A 1 424 ? 50.676  -54.046 -7.598  1.000 37.890  0 428 VAL A CG2 1 
ATOM   3189 N N   . ASP A 1 425 ? 51.053  -52.190 -10.674 1.000 38.380  0 429 ASP A N   1 
ATOM   3190 C CA  . ASP A 1 425 ? 51.913  -51.018 -10.682 1.000 45.600  0 429 ASP A CA  1 
ATOM   3191 C C   . ASP A 1 425 ? 52.092  -50.496 -9.259  1.000 40.730  0 429 ASP A C   1 
ATOM   3192 O O   . ASP A 1 425 ? 51.171  -50.555 -8.445  1.000 40.640  0 429 ASP A O   1 
ATOM   3193 C CB  . ASP A 1 425 ? 51.288  -49.941 -11.565 1.000 43.290  0 429 ASP A CB  1 
ATOM   3194 C CG  . ASP A 1 425 ? 52.253  -48.838 -11.915 1.000 61.720  0 429 ASP A CG  1 
ATOM   3195 O OD1 . ASP A 1 425 ? 52.706  -48.120 -10.993 1.000 53.070  0 429 ASP A OD1 1 
ATOM   3196 O OD2 . ASP A 1 425 ? 52.543  -48.686 -13.122 1.000 74.420  0 429 ASP A OD2 1 
ATOM   3197 N N   . LYS A 1 426 ? 53.292  -49.968 -8.965  1.000 38.340  0 430 LYS A N   1 
ATOM   3198 C CA  . LYS A 1 426 ? 53.582  -49.472 -7.616  1.000 39.050  0 430 LYS A CA  1 
ATOM   3199 C C   . LYS A 1 426 ? 52.589  -48.408 -7.169  1.000 34.810  0 430 LYS A C   1 
ATOM   3200 O O   . LYS A 1 426 ? 52.306  -48.282 -5.968  1.000 36.330  0 430 LYS A O   1 
ATOM   3201 C CB  . LYS A 1 426 ? 55.004  -48.896 -7.551  1.000 43.740  0 430 LYS A CB  1 
ATOM   3202 C CG  . LYS A 1 426 ? 56.079  -49.910 -7.223  1.000 47.500  0 430 LYS A CG  1 
ATOM   3203 C CD  . LYS A 1 426 ? 57.454  -49.256 -6.965  1.000 48.070  0 430 LYS A CD  1 
ATOM   3204 C CE  . LYS A 1 426 ? 57.902  -48.341 -8.101  1.000 46.450  0 430 LYS A CE  1 
ATOM   3205 N NZ  . LYS A 1 426 ? 59.412  -48.194 -8.116  1.000 48.030  0 430 LYS A NZ  1 
ATOM   3206 N N   . ASN A 1 427 ? 52.055  -47.632 -8.114  1.000 38.750  0 431 ASN A N   1 
ATOM   3207 C CA  . ASN A 1 427 ? 51.106  -46.561 -7.838  1.000 36.560  0 431 ASN A CA  1 
ATOM   3208 C C   . ASN A 1 427 ? 49.671  -46.974 -8.100  1.000 39.680  0 431 ASN A C   1 
ATOM   3209 O O   . ASN A 1 427 ? 48.785  -46.111 -8.190  1.000 43.110  0 431 ASN A O   1 
ATOM   3210 C CB  . ASN A 1 427 ? 51.443  -45.331 -8.676  1.000 43.930  0 431 ASN A CB  1 
ATOM   3211 C CG  . ASN A 1 427 ? 52.850  -44.855 -8.446  1.000 54.400  0 431 ASN A CG  1 
ATOM   3212 O OD1 . ASN A 1 427 ? 53.347  -44.879 -7.319  1.000 54.320  0 431 ASN A OD1 1 
ATOM   3213 N ND2 . ASN A 1 427 ? 53.509  -44.426 -9.514  1.000 70.460  0 431 ASN A ND2 1 
ATOM   3214 N N   . GLY A 1 428 ? 49.417  -48.269 -8.235  1.000 41.180  0 432 GLY A N   1 
ATOM   3215 C CA  . GLY A 1 428 ? 48.067  -48.726 -8.440  1.000 37.410  0 432 GLY A CA  1 
ATOM   3216 C C   . GLY A 1 428 ? 47.622  -48.597 -9.887  1.000 36.160  0 432 GLY A C   1 
ATOM   3217 O O   . GLY A 1 428 ? 48.354  -48.085 -10.741 1.000 40.220  0 432 GLY A O   1 
ATOM   3218 N N   . PRO A 1 429 ? 46.400  -49.073 -10.196 1.000 36.140  0 433 PRO A N   1 
ATOM   3219 C CA  . PRO A 1 429 ? 45.486  -49.676 -9.216  1.000 38.550  0 433 PRO A CA  1 
ATOM   3220 C C   . PRO A 1 429 ? 45.964  -51.046 -8.712  1.000 38.460  0 433 PRO A C   1 
ATOM   3221 O O   . PRO A 1 429 ? 46.704  -51.761 -9.404  1.000 36.830  0 433 PRO A O   1 
ATOM   3222 C CB  . PRO A 1 429 ? 44.163  -49.794 -9.990  1.000 39.110  0 433 PRO A CB  1 
ATOM   3223 C CG  . PRO A 1 429 ? 44.585  -49.966 -11.412 1.000 43.140  0 433 PRO A CG  1 
ATOM   3224 C CD  . PRO A 1 429 ? 45.885  -49.163 -11.575 1.000 39.210  0 433 PRO A CD  1 
ATOM   3225 N N   . TYR A 1 430 ? 45.576  -51.365 -7.482  1.000 34.860  0 434 TYR A N   1 
ATOM   3226 C CA  . TYR A 1 430 ? 46.135  -52.476 -6.727  1.000 35.320  0 434 TYR A CA  1 
ATOM   3227 C C   . TYR A 1 430 ? 45.279  -53.729 -6.754  1.000 37.790  0 434 TYR A C   1 
ATOM   3228 O O   . TYR A 1 430 ? 45.729  -54.764 -6.246  1.000 34.540  0 434 TYR A O   1 
ATOM   3229 C CB  . TYR A 1 430 ? 46.336  -52.068 -5.264  1.000 30.990  0 434 TYR A CB  1 
ATOM   3230 C CG  . TYR A 1 430 ? 47.277  -50.902 -5.134  1.000 35.090  0 434 TYR A CG  1 
ATOM   3231 C CD1 . TYR A 1 430 ? 48.620  -51.042 -5.444  1.000 32.810  0 434 TYR A CD1 1 
ATOM   3232 C CD2 . TYR A 1 430 ? 46.813  -49.651 -4.740  1.000 37.840  0 434 TYR A CD2 1 
ATOM   3233 C CE1 . TYR A 1 430 ? 49.496  -49.964 -5.346  1.000 34.880  0 434 TYR A CE1 1 
ATOM   3234 C CE2 . TYR A 1 430 ? 47.683  -48.565 -4.640  1.000 34.450  0 434 TYR A CE2 1 
ATOM   3235 C CZ  . TYR A 1 430 ? 49.016  -48.736 -4.936  1.000 35.600  0 434 TYR A CZ  1 
ATOM   3236 O OH  . TYR A 1 430 ? 49.874  -47.662 -4.838  1.000 37.810  0 434 TYR A OH  1 
ATOM   3237 N N   . LYS A 1 431 ? 44.064  -53.656 -7.296  1.000 33.930  0 435 LYS A N   1 
ATOM   3238 C CA  . LYS A 1 431 ? 43.106  -54.754 -7.293  1.000 33.980  0 435 LYS A CA  1 
ATOM   3239 C C   . LYS A 1 431 ? 42.498  -54.936 -8.676  1.000 36.430  0 435 LYS A C   1 
ATOM   3240 O O   . LYS A 1 431 ? 42.330  -53.965 -9.419  1.000 36.550  0 435 LYS A O   1 
ATOM   3241 C CB  . LYS A 1 431 ? 41.958  -54.505 -6.293  1.000 33.950  0 435 LYS A CB  1 
ATOM   3242 C CG  . LYS A 1 431 ? 42.363  -54.392 -4.820  1.000 33.910  0 435 LYS A CG  1 
ATOM   3243 C CD  . LYS A 1 431 ? 42.946  -55.702 -4.297  1.000 34.050  0 435 LYS A CD  1 
ATOM   3244 C CE  . LYS A 1 431 ? 43.248  -55.621 -2.799  1.000 32.280  0 435 LYS A CE  1 
ATOM   3245 N NZ  . LYS A 1 431 ? 44.309  -54.615 -2.503  1.000 31.350  0 435 LYS A NZ  1 
ATOM   3246 N N   . PRO A 1 432 ? 42.113  -56.165 -9.030  1.000 42.750  0 436 PRO A N   1 
ATOM   3247 C CA  . PRO A 1 432 ? 41.360  -56.372 -10.276 1.000 46.620  0 436 PRO A CA  1 
ATOM   3248 C C   . PRO A 1 432 ? 40.026  -55.649 -10.238 1.000 39.510  0 436 PRO A C   1 
ATOM   3249 O O   . PRO A 1 432 ? 39.494  -55.322 -9.171  1.000 37.330  0 436 PRO A O   1 
ATOM   3250 C CB  . PRO A 1 432 ? 41.166  -57.893 -10.343 1.000 49.090  0 436 PRO A CB  1 
ATOM   3251 C CG  . PRO A 1 432 ? 41.407  -58.382 -8.946  1.000 52.290  0 436 PRO A CG  1 
ATOM   3252 C CD  . PRO A 1 432 ? 42.373  -57.426 -8.312  1.000 47.970  0 436 PRO A CD  1 
ATOM   3253 N N   . ASP A 1 433 ? 39.480  -55.407 -11.438 1.000 40.410  0 437 ASP A N   1 
ATOM   3254 C CA  . ASP A 1 433 ? 38.288  -54.568 -11.565 1.000 45.410  0 437 ASP A CA  1 
ATOM   3255 C C   . ASP A 1 433 ? 37.121  -55.081 -10.730 1.000 49.270  0 437 ASP A C   1 
ATOM   3256 O O   . ASP A 1 433 ? 36.330  -54.282 -10.219 1.000 51.410  0 437 ASP A O   1 
ATOM   3257 C CB  . ASP A 1 433 ? 37.869  -54.467 -13.031 1.000 53.810  0 437 ASP A CB  1 
ATOM   3258 C CG  . ASP A 1 433 ? 38.884  -53.727 -13.870 1.000 74.060  0 437 ASP A CG  1 
ATOM   3259 O OD1 . ASP A 1 433 ? 39.525  -52.800 -13.330 1.000 78.690  0 437 ASP A OD1 1 
ATOM   3260 O OD2 . ASP A 1 433 ? 39.042  -54.074 -15.060 1.000 80.180  0 437 ASP A OD2 1 
ATOM   3261 N N   . HIS A 1 434 ? 36.995  -56.393 -10.564 1.000 41.330  0 438 HIS A N   1 
ATOM   3262 C CA  . HIS A 1 434 ? 35.834  -56.945 -9.872  1.000 53.180  0 438 HIS A CA  1 
ATOM   3263 C C   . HIS A 1 434 ? 36.139  -57.377 -8.434  1.000 49.800  0 438 HIS A C   1 
ATOM   3264 O O   . HIS A 1 434 ? 35.342  -58.099 -7.821  1.000 41.380  0 438 HIS A O   1 
ATOM   3265 C CB  . HIS A 1 434 ? 35.253  -58.092 -10.697 1.000 53.320  0 438 HIS A CB  1 
ATOM   3266 C CG  . HIS A 1 434 ? 34.906  -57.696 -12.104 1.000 61.200  0 438 HIS A CG  1 
ATOM   3267 N ND1 . HIS A 1 434 ? 34.545  -56.410 -12.451 1.000 59.570  0 438 HIS A ND1 1 
ATOM   3268 C CD2 . HIS A 1 434 ? 34.885  -58.412 -13.254 1.000 63.180  0 438 HIS A CD2 1 
ATOM   3269 C CE1 . HIS A 1 434 ? 34.310  -56.352 -13.750 1.000 60.420  0 438 HIS A CE1 1 
ATOM   3270 N NE2 . HIS A 1 434 ? 34.504  -57.555 -14.259 1.000 62.850  0 438 HIS A NE2 1 
ATOM   3271 N N   . TYR A 1 435 ? 37.260  -56.927 -7.876  1.000 34.930  0 439 TYR A N   1 
ATOM   3272 C CA  . TYR A 1 435 ? 37.529  -57.135 -6.460  1.000 32.050  0 439 TYR A CA  1 
ATOM   3273 C C   . TYR A 1 435 ? 36.441  -56.478 -5.621  1.000 38.700  0 439 TYR A C   1 
ATOM   3274 O O   . TYR A 1 435 ? 35.981  -55.373 -5.928  1.000 38.630  0 439 TYR A O   1 
ATOM   3275 C CB  . TYR A 1 435 ? 38.904  -56.555 -6.102  1.000 30.730  0 439 TYR A CB  1 
ATOM   3276 C CG  . TYR A 1 435 ? 39.384  -56.887 -4.713  1.000 33.030  0 439 TYR A CG  1 
ATOM   3277 C CD1 . TYR A 1 435 ? 39.900  -58.149 -4.422  1.000 33.500  0 439 TYR A CD1 1 
ATOM   3278 C CD2 . TYR A 1 435 ? 39.357  -55.940 -3.694  1.000 30.640  0 439 TYR A CD2 1 
ATOM   3279 C CE1 . TYR A 1 435 ? 40.363  -58.461 -3.148  1.000 30.210  0 439 TYR A CE1 1 
ATOM   3280 C CE2 . TYR A 1 435 ? 39.820  -56.246 -2.411  1.000 33.550  0 439 TYR A CE2 1 
ATOM   3281 C CZ  . TYR A 1 435 ? 40.312  -57.515 -2.154  1.000 32.520  0 439 TYR A CZ  1 
ATOM   3282 O OH  . TYR A 1 435 ? 40.761  -57.838 -0.907  1.000 32.360  0 439 TYR A OH  1 
ATOM   3283 N N   . ARG A 1 436 ? 36.033  -57.161 -4.550  1.000 37.440  0 440 ARG A N   1 
ATOM   3284 C CA  . ARG A 1 436 ? 34.869  -56.753 -3.774  1.000 34.850  0 440 ARG A CA  1 
ATOM   3285 C C   . ARG A 1 436 ? 35.204  -56.060 -2.458  1.000 38.530  0 440 ARG A C   1 
ATOM   3286 O O   . ARG A 1 436 ? 34.295  -55.507 -1.829  1.000 34.390  0 440 ARG A O   1 
ATOM   3287 C CB  . ARG A 1 436 ? 33.964  -57.973 -3.503  1.000 32.670  0 440 ARG A CB  1 
ATOM   3288 C CG  . ARG A 1 436 ? 33.426  -58.640 -4.783  1.000 31.280  0 440 ARG A CG  1 
ATOM   3289 C CD  . ARG A 1 436 ? 32.199  -59.520 -4.506  1.000 29.280  0 440 ARG A CD  1 
ATOM   3290 N NE  . ARG A 1 436 ? 31.500  -59.909 -5.730  1.000 34.190  0 440 ARG A NE  1 
ATOM   3291 C CZ  . ARG A 1 436 ? 31.828  -60.966 -6.475  1.000 40.530  0 440 ARG A CZ  1 
ATOM   3292 N NH1 . ARG A 1 436 ? 32.856  -61.736 -6.121  1.000 42.150  0 440 ARG A NH1 1 
ATOM   3293 N NH2 . ARG A 1 436 ? 31.144  -61.251 -7.574  1.000 36.700  0 440 ARG A NH2 1 
ATOM   3294 N N   . TYR A 1 437 ? 36.470  -56.061 -2.031  1.000 33.940  0 441 TYR A N   1 
ATOM   3295 C CA  . TYR A 1 437 ? 36.881  -55.439 -0.770  1.000 34.800  0 441 TYR A CA  1 
ATOM   3296 C C   . TYR A 1 437 ? 36.044  -55.978 0.388   1.000 37.390  0 441 TYR A C   1 
ATOM   3297 O O   . TYR A 1 437 ? 35.520  -57.105 0.352   1.000 33.560  0 441 TYR A O   1 
ATOM   3298 C CB  . TYR A 1 437 ? 36.794  -53.896 -0.848  1.000 32.240  0 441 TYR A CB  1 
ATOM   3299 C CG  . TYR A 1 437 ? 37.599  -53.312 -1.996  1.000 32.150  0 441 TYR A CG  1 
ATOM   3300 C CD1 . TYR A 1 437 ? 37.070  -53.262 -3.272  1.000 34.180  0 441 TYR A CD1 1 
ATOM   3301 C CD2 . TYR A 1 437 ? 38.913  -52.852 -1.806  1.000 32.960  0 441 TYR A CD2 1 
ATOM   3302 C CE1 . TYR A 1 437 ? 37.790  -52.751 -4.336  1.000 32.610  0 441 TYR A CE1 1 
ATOM   3303 C CE2 . TYR A 1 437 ? 39.653  -52.345 -2.873  1.000 27.330  0 441 TYR A CE2 1 
ATOM   3304 C CZ  . TYR A 1 437 ? 39.082  -52.293 -4.130  1.000 31.740  0 441 TYR A CZ  1 
ATOM   3305 O OH  . TYR A 1 437 ? 39.765  -51.806 -5.214  1.000 32.320  0 441 TYR A OH  1 
ATOM   3306 O OXT . TYR A 1 437 ? 35.897  -55.302 1.396   1.000 35.930  0 441 TYR A OXT 1 
HETATM 3307 S S   . SO4 B 2 .   ? 20.076  -41.652 0.737   1.000 42.060  0 501 SO4 A S   1 
HETATM 3308 O O1  . SO4 B 2 .   ? 21.275  -42.311 0.245   1.000 40.580  0 501 SO4 A O1  1 
HETATM 3309 O O2  . SO4 B 2 .   ? 19.790  -40.456 -0.056  1.000 41.080  0 501 SO4 A O2  1 
HETATM 3310 O O3  . SO4 B 2 .   ? 18.942  -42.579 0.678   1.000 40.560  0 501 SO4 A O3  1 
HETATM 3311 O O4  . SO4 B 2 .   ? 20.306  -41.244 2.112   1.000 36.660  0 501 SO4 A O4  1 
HETATM 3312 P PA  . NAD C 3 .   ? 21.669  -52.876 -0.976  1.000 35.840  0 502 NAD A PA  1 
HETATM 3313 O O1A . NAD C 3 .   ? 21.007  -53.319 -2.230  1.000 36.210  0 502 NAD A O1A 1 
HETATM 3314 O O2A . NAD C 3 .   ? 23.136  -53.067 -0.832  1.000 35.090  0 502 NAD A O2A 1 
HETATM 3315 O O5B . NAD C 3 .   ? 20.936  -53.532 0.278   1.000 35.250  0 502 NAD A O5B 1 
HETATM 3316 C C5B . NAD C 3 .   ? 19.513  -53.744 0.249   1.000 36.680  0 502 NAD A C5B 1 
HETATM 3317 C C4B . NAD C 3 .   ? 19.246  -55.147 0.726   1.000 32.780  0 502 NAD A C4B 1 
HETATM 3318 O O4B . NAD C 3 .   ? 17.833  -55.302 0.995   1.000 32.550  0 502 NAD A O4B 1 
HETATM 3319 C C3B . NAD C 3 .   ? 19.618  -56.260 -0.268  1.000 43.660  0 502 NAD A C3B 1 
HETATM 3320 O O3B . NAD C 3 .   ? 20.563  -57.158 0.298   1.000 33.400  0 502 NAD A O3B 1 
HETATM 3321 C C2B . NAD C 3 .   ? 18.284  -56.952 -0.570  1.000 34.730  0 502 NAD A C2B 1 
HETATM 3322 O O2B . NAD C 3 .   ? 18.430  -58.342 -0.736  1.000 28.350  0 502 NAD A O2B 1 
HETATM 3323 C C1B . NAD C 3 .   ? 17.481  -56.623 0.681   1.000 33.220  0 502 NAD A C1B 1 
HETATM 3324 N N9A . NAD C 3 .   ? 16.039  -56.699 0.502   1.000 35.850  0 502 NAD A N9A 1 
HETATM 3325 C C8A . NAD C 3 .   ? 15.316  -56.303 -0.592  1.000 39.870  0 502 NAD A C8A 1 
HETATM 3326 N N7A . NAD C 3 .   ? 14.030  -56.501 -0.460  1.000 35.060  0 502 NAD A N7A 1 
HETATM 3327 C C5A . NAD C 3 .   ? 13.898  -57.065 0.799   1.000 37.950  0 502 NAD A C5A 1 
HETATM 3328 C C6A . NAD C 3 .   ? 12.778  -57.502 1.526   1.000 35.430  0 502 NAD A C6A 1 
HETATM 3329 N N6A . NAD C 3 .   ? 11.534  -57.445 1.065   1.000 30.860  0 502 NAD A N6A 1 
HETATM 3330 N N1A . NAD C 3 .   ? 12.995  -58.012 2.759   1.000 32.670  0 502 NAD A N1A 1 
HETATM 3331 C C2A . NAD C 3 .   ? 14.251  -58.075 3.212   1.000 37.840  0 502 NAD A C2A 1 
HETATM 3332 N N3A . NAD C 3 .   ? 15.377  -57.695 2.621   1.000 34.460  0 502 NAD A N3A 1 
HETATM 3333 C C4A . NAD C 3 .   ? 15.131  -57.192 1.403   1.000 35.430  0 502 NAD A C4A 1 
HETATM 3334 O O3  . NAD C 3 .   ? 21.337  -51.338 -0.716  1.000 32.200  0 502 NAD A O3  1 
HETATM 3335 P PN  . NAD C 3 .   ? 21.989  -50.354 0.360   1.000 35.070  0 502 NAD A PN  1 
HETATM 3336 O O1N . NAD C 3 .   ? 23.195  -49.728 -0.241  1.000 34.450  0 502 NAD A O1N 1 
HETATM 3337 O O2N . NAD C 3 .   ? 22.135  -51.080 1.647   1.000 30.180  0 502 NAD A O2N 1 
HETATM 3338 O O5D . NAD C 3 .   ? 20.850  -49.250 0.497   1.000 34.020  0 502 NAD A O5D 1 
HETATM 3339 C C5D . NAD C 3 .   ? 19.552  -49.613 1.008   1.000 39.460  0 502 NAD A C5D 1 
HETATM 3340 C C4D . NAD C 3 .   ? 18.647  -48.408 0.945   1.000 33.570  0 502 NAD A C4D 1 
HETATM 3341 O O4D . NAD C 3 .   ? 19.169  -47.362 1.791   1.000 36.950  0 502 NAD A O4D 1 
HETATM 3342 C C3D . NAD C 3 .   ? 18.481  -47.757 -0.435  1.000 38.300  0 502 NAD A C3D 1 
HETATM 3343 O O3D . NAD C 3 .   ? 17.184  -47.193 -0.540  1.000 32.570  0 502 NAD A O3D 1 
HETATM 3344 C C2D . NAD C 3 .   ? 19.553  -46.665 -0.422  1.000 47.050  0 502 NAD A C2D 1 
HETATM 3345 O O2D . NAD C 3 .   ? 19.290  -45.636 -1.360  1.000 34.620  0 502 NAD A O2D 1 
HETATM 3346 C C1D . NAD C 3 .   ? 19.391  -46.186 1.022   1.000 45.610  0 502 NAD A C1D 1 
HETATM 3347 N N1N . NAD C 3 .   ? 20.557  -45.500 1.601   1.000 41.170  0 502 NAD A N1N 1 
HETATM 3348 C C2N . NAD C 3 .   ? 20.389  -44.729 2.725   1.000 34.220  0 502 NAD A C2N 1 
HETATM 3349 C C3N . NAD C 3 .   ? 21.480  -44.087 3.292   1.000 36.390  0 502 NAD A C3N 1 
HETATM 3350 C C7N . NAD C 3 .   ? 21.246  -43.250 4.509   1.000 39.410  0 502 NAD A C7N 1 
HETATM 3351 O O7N . NAD C 3 .   ? 22.088  -42.411 4.852   1.000 35.350  0 502 NAD A O7N 1 
HETATM 3352 N N7N . NAD C 3 .   ? 20.124  -43.436 5.185   1.000 35.730  0 502 NAD A N7N 1 
HETATM 3353 C C4N . NAD C 3 .   ? 22.738  -44.232 2.728   1.000 33.460  0 502 NAD A C4N 1 
HETATM 3354 C C5N . NAD C 3 .   ? 22.894  -45.019 1.605   1.000 31.230  0 502 NAD A C5N 1 
HETATM 3355 C C6N . NAD C 3 .   ? 21.803  -45.652 1.049   1.000 34.370  0 502 NAD A C6N 1 
HETATM 3356 O O   . HOH D 4 .   ? 14.861  -25.175 -17.700 1.000 68.620  0 601 HOH A O   1 
HETATM 3357 O O   . HOH D 4 .   ? 26.821  -49.640 -12.235 1.000 41.480  0 602 HOH A O   1 
HETATM 3358 O O   . HOH D 4 .   ? 35.554  -60.389 -7.778  1.000 51.140  0 603 HOH A O   1 
HETATM 3359 O O   . HOH D 4 .   ? 18.048  -70.510 14.845  1.000 62.850  0 604 HOH A O   1 
HETATM 3360 O O   . HOH D 4 .   ? 1.773   -57.555 19.815  1.000 52.580  0 605 HOH A O   1 
HETATM 3361 O O   . HOH D 4 .   ? 23.436  -66.894 13.031  1.000 48.980  0 606 HOH A O   1 
HETATM 3362 O O   . HOH D 4 .   ? 24.949  -33.161 9.367   1.000 59.820  0 607 HOH A O   1 
HETATM 3363 O O   . HOH D 4 .   ? 33.425  -36.135 10.731  1.000 43.000  0 608 HOH A O   1 
HETATM 3364 O O   . HOH D 4 .   ? 25.429  -40.088 0.314   1.000 49.420  0 609 HOH A O   1 
HETATM 3365 O O   . HOH D 4 .   ? 10.377  -40.458 1.217   1.000 37.010  0 610 HOH A O   1 
HETATM 3366 O O   . HOH D 4 .   ? -6.153  -48.893 8.153   1.000 102.690 0 611 HOH A O   1 
HETATM 3367 O O   . HOH D 4 .   ? 39.550  -35.073 -16.326 1.000 59.350  0 612 HOH A O   1 
HETATM 3368 O O   . HOH D 4 .   ? 37.632  -24.492 8.833   1.000 51.720  0 613 HOH A O   1 
HETATM 3369 O O   . HOH D 4 .   ? 15.705  -67.915 11.819  1.000 65.500  0 614 HOH A O   1 
HETATM 3370 O O   . HOH D 4 .   ? 32.794  -25.120 2.353   1.000 45.800  0 615 HOH A O   1 
HETATM 3371 O O   . HOH D 4 .   ? 6.622   -56.033 18.638  1.000 38.930  0 616 HOH A O   1 
HETATM 3372 O O   . HOH D 4 .   ? 0.561   -63.741 15.256  1.000 58.120  0 617 HOH A O   1 
HETATM 3373 O O   . HOH D 4 .   ? 16.708  -45.056 -25.194 1.000 64.790  0 618 HOH A O   1 
HETATM 3374 O O   . HOH D 4 .   ? 38.226  -32.026 12.468  1.000 47.110  0 619 HOH A O   1 
HETATM 3375 O O   . HOH D 4 .   ? -12.518 -46.732 6.277   1.000 41.220  0 620 HOH A O   1 
HETATM 3376 O O   . HOH D 4 .   ? 4.589   -34.367 6.772   1.000 69.100  0 621 HOH A O   1 
HETATM 3377 O O   . HOH D 4 .   ? 14.138  -64.729 -1.385  1.000 32.730  0 622 HOH A O   1 
HETATM 3378 O O   . HOH D 4 .   ? 6.621   -37.283 -14.102 1.000 50.820  0 623 HOH A O   1 
HETATM 3379 O O   . HOH D 4 .   ? 57.212  -52.819 0.824   1.000 46.350  0 624 HOH A O   1 
HETATM 3380 O O   . HOH D 4 .   ? 22.385  -62.765 17.734  1.000 52.910  0 625 HOH A O   1 
HETATM 3381 O O   . HOH D 4 .   ? 2.098   -27.312 -0.039  1.000 60.190  0 626 HOH A O   1 
HETATM 3382 O O   . HOH D 4 .   ? -0.192  -52.499 4.510   1.000 38.610  0 627 HOH A O   1 
HETATM 3383 O O   . HOH D 4 .   ? 42.180  -51.009 -4.922  1.000 35.620  0 628 HOH A O   1 
HETATM 3384 O O   . HOH D 4 .   ? 31.867  -31.767 11.011  1.000 41.860  0 629 HOH A O   1 
HETATM 3385 O O   . HOH D 4 .   ? 60.919  -56.298 -1.567  1.000 37.910  0 630 HOH A O   1 
HETATM 3386 O O   . HOH D 4 .   ? 32.511  -59.225 9.179   1.000 54.490  0 631 HOH A O   1 
HETATM 3387 O O   . HOH D 4 .   ? 4.699   -29.106 -6.633  1.000 55.500  0 632 HOH A O   1 
HETATM 3388 O O   . HOH D 4 .   ? 44.956  -43.412 -7.660  1.000 48.970  0 633 HOH A O   1 
HETATM 3389 O O   . HOH D 4 .   ? 63.677  -59.485 -1.006  1.000 39.490  0 634 HOH A O   1 
HETATM 3390 O O   . HOH D 4 .   ? 8.586   -57.801 5.063   1.000 41.760  0 635 HOH A O   1 
HETATM 3391 O O   . HOH D 4 .   ? 46.493  -55.683 -3.958  1.000 37.100  0 636 HOH A O   1 
HETATM 3392 O O   . HOH D 4 .   ? 17.020  -33.551 12.248  1.000 51.980  0 637 HOH A O   1 
HETATM 3393 O O   . HOH D 4 .   ? 16.968  -53.853 -22.672 1.000 63.240  0 638 HOH A O   1 
HETATM 3394 O O   . HOH D 4 .   ? 5.678   -36.893 -3.238  1.000 56.130  0 639 HOH A O   1 
HETATM 3395 O O   . HOH D 4 .   ? 14.318  -30.835 3.290   1.000 45.830  0 640 HOH A O   1 
HETATM 3396 O O   . HOH D 4 .   ? 37.852  -37.285 -15.206 1.000 58.600  0 641 HOH A O   1 
HETATM 3397 O O   . HOH D 4 .   ? 24.754  -40.195 -24.917 1.000 66.350  0 642 HOH A O   1 
HETATM 3398 O O   . HOH D 4 .   ? 16.926  -21.514 6.555   1.000 44.650  0 643 HOH A O   1 
HETATM 3399 O O   . HOH D 4 .   ? 19.052  -54.527 -3.439  1.000 42.290  0 644 HOH A O   1 
HETATM 3400 O O   . HOH D 4 .   ? 11.014  -60.589 22.048  1.000 54.210  0 645 HOH A O   1 
HETATM 3401 O O   . HOH D 4 .   ? 25.722  -36.110 14.311  1.000 52.860  0 646 HOH A O   1 
HETATM 3402 O O   . HOH D 4 .   ? 6.625   -39.559 12.744  1.000 45.340  0 647 HOH A O   1 
HETATM 3403 O O   . HOH D 4 .   ? 54.553  -54.574 -11.817 1.000 49.440  0 648 HOH A O   1 
HETATM 3404 O O   . HOH D 4 .   ? 36.377  -53.494 -7.732  1.000 36.220  0 649 HOH A O   1 
HETATM 3405 O O   . HOH D 4 .   ? -4.452  -38.055 13.576  1.000 63.730  0 650 HOH A O   1 
HETATM 3406 O O   . HOH D 4 .   ? -4.145  -56.029 9.839   1.000 44.710  0 651 HOH A O   1 
HETATM 3407 O O   . HOH D 4 .   ? -0.702  -47.510 24.687  1.000 54.800  0 652 HOH A O   1 
HETATM 3408 O O   . HOH D 4 .   ? 23.820  -41.994 -0.300  1.000 37.530  0 653 HOH A O   1 
HETATM 3409 O O   . HOH D 4 .   ? 41.634  -52.768 -11.649 1.000 41.500  0 654 HOH A O   1 
HETATM 3410 O O   . HOH D 4 .   ? 8.308   -37.519 1.421   1.000 46.950  0 655 HOH A O   1 
HETATM 3411 O O   . HOH D 4 .   ? 46.348  -45.557 -6.561  1.000 41.250  0 656 HOH A O   1 
HETATM 3412 O O   . HOH D 4 .   ? 13.402  -30.443 -3.252  1.000 44.530  0 657 HOH A O   1 
HETATM 3413 O O   . HOH D 4 .   ? -10.863 -42.854 12.273  1.000 53.150  0 658 HOH A O   1 
HETATM 3414 O O   . HOH D 4 .   ? 25.304  -50.126 -1.772  1.000 37.210  0 659 HOH A O   1 
HETATM 3415 O O   . HOH D 4 .   ? 30.451  -60.784 13.795  1.000 49.220  0 660 HOH A O   1 
HETATM 3416 O O   . HOH D 4 .   ? 31.784  -42.658 1.472   1.000 38.120  0 661 HOH A O   1 
HETATM 3417 O O   . HOH D 4 .   ? 19.489  -36.695 -24.567 1.000 59.070  0 662 HOH A O   1 
HETATM 3418 O O   . HOH D 4 .   ? 17.700  -31.592 9.537   1.000 49.660  0 663 HOH A O   1 
HETATM 3419 O O   . HOH D 4 .   ? 48.400  -51.709 -11.430 1.000 40.810  0 664 HOH A O   1 
HETATM 3420 O O   . HOH D 4 .   ? 29.818  -53.902 2.668   1.000 45.860  0 665 HOH A O   1 
HETATM 3421 O O   . HOH D 4 .   ? 12.636  -41.442 -20.987 1.000 49.150  0 666 HOH A O   1 
HETATM 3422 O O   . HOH D 4 .   ? -3.313  -45.353 23.999  1.000 50.230  0 667 HOH A O   1 
HETATM 3423 O O   . HOH D 4 .   ? 16.147  -51.913 27.468  1.000 37.660  0 668 HOH A O   1 
HETATM 3424 O O   . HOH D 4 .   ? 48.721  -48.552 -13.321 1.000 52.580  0 669 HOH A O   1 
HETATM 3425 O O   . HOH D 4 .   ? 2.149   -38.842 23.066  1.000 44.490  0 670 HOH A O   1 
HETATM 3426 O O   . HOH D 4 .   ? 9.966   -40.432 -6.092  1.000 53.710  0 671 HOH A O   1 
HETATM 3427 O O   . HOH D 4 .   ? 9.568   -48.165 23.353  1.000 41.440  0 672 HOH A O   1 
HETATM 3428 O O   . HOH D 4 .   ? 14.424  -38.475 -3.294  1.000 39.030  0 673 HOH A O   1 
HETATM 3429 O O   . HOH D 4 .   ? 3.550   -51.117 27.208  1.000 49.280  0 674 HOH A O   1 
HETATM 3430 O O   . HOH D 4 .   ? 21.766  -53.733 -4.739  1.000 47.240  0 675 HOH A O   1 
HETATM 3431 O O   . HOH D 4 .   ? 19.645  -40.865 -11.127 1.000 39.190  0 676 HOH A O   1 
HETATM 3432 O O   . HOH D 4 .   ? 7.477   -66.196 7.234   1.000 45.100  0 677 HOH A O   1 
HETATM 3433 O O   . HOH D 4 .   ? 12.707  -41.150 2.939   1.000 37.170  0 678 HOH A O   1 
HETATM 3434 O O   . HOH D 4 .   ? 16.811  -51.871 -11.208 1.000 53.760  0 679 HOH A O   1 
HETATM 3435 O O   . HOH D 4 .   ? 14.202  -29.023 -1.416  1.000 40.630  0 680 HOH A O   1 
HETATM 3436 O O   . HOH D 4 .   ? 4.173   -23.010 0.213   1.000 68.600  0 681 HOH A O   1 
HETATM 3437 O O   . HOH D 4 .   ? 41.844  -36.380 -10.299 1.000 47.940  0 682 HOH A O   1 
HETATM 3438 O O   . HOH D 4 .   ? 26.877  -56.085 10.208  1.000 35.140  0 683 HOH A O   1 
HETATM 3439 O O   . HOH D 4 .   ? 18.123  -45.901 -22.773 1.000 53.750  0 684 HOH A O   1 
HETATM 3440 O O   . HOH D 4 .   ? 4.244   -56.305 1.195   1.000 37.680  0 685 HOH A O   1 
HETATM 3441 O O   . HOH D 4 .   ? 3.427   -60.135 4.867   1.000 54.520  0 686 HOH A O   1 
HETATM 3442 O O   . HOH D 4 .   ? 6.528   -60.500 24.067  1.000 68.520  0 687 HOH A O   1 
HETATM 3443 O O   . HOH D 4 .   ? 15.561  -49.412 -4.556  1.000 37.050  0 688 HOH A O   1 
HETATM 3444 O O   . HOH D 4 .   ? 1.579   -58.661 6.583   1.000 50.310  0 689 HOH A O   1 
HETATM 3445 O O   . HOH D 4 .   ? 16.818  -53.669 -2.786  1.000 46.670  0 690 HOH A O   1 
HETATM 3446 O O   . HOH D 4 .   ? 44.095  -35.077 1.592   1.000 46.810  0 691 HOH A O   1 
HETATM 3447 O O   . HOH D 4 .   ? 20.653  -52.696 3.442   1.000 30.780  0 692 HOH A O   1 
HETATM 3448 O O   . HOH D 4 .   ? 30.868  -32.625 -22.378 1.000 59.480  0 693 HOH A O   1 
HETATM 3449 O O   . HOH D 4 .   ? 5.905   -63.398 16.796  1.000 49.550  0 694 HOH A O   1 
HETATM 3450 O O   . HOH D 4 .   ? 30.103  -51.356 -4.195  1.000 33.650  0 695 HOH A O   1 
HETATM 3451 O O   . HOH D 4 .   ? 6.523   -26.570 4.790   1.000 54.880  0 696 HOH A O   1 
HETATM 3452 O O   . HOH D 4 .   ? 4.906   -44.895 2.648   1.000 41.640  0 697 HOH A O   1 
HETATM 3453 O O   . HOH D 4 .   ? 54.522  -52.474 6.421   1.000 34.450  0 698 HOH A O   1 
HETATM 3454 O O   . HOH D 4 .   ? 11.960  -25.435 8.366   1.000 41.270  0 699 HOH A O   1 
HETATM 3455 O O   . HOH D 4 .   ? 31.078  -45.841 11.989  1.000 36.330  0 700 HOH A O   1 
HETATM 3456 O O   . HOH D 4 .   ? 30.232  -29.354 11.344  1.000 39.760  0 701 HOH A O   1 
HETATM 3457 O O   . HOH D 4 .   ? 33.936  -55.837 3.192   1.000 34.690  0 702 HOH A O   1 
HETATM 3458 O O   . HOH D 4 .   ? 25.604  -51.477 -4.343  1.000 40.000  0 703 HOH A O   1 
HETATM 3459 O O   . HOH D 4 .   ? 48.875  -41.622 4.567   1.000 59.720  0 704 HOH A O   1 
HETATM 3460 O O   . HOH D 4 .   ? 55.830  -48.159 -4.315  1.000 48.990  0 705 HOH A O   1 
HETATM 3461 O O   . HOH D 4 .   ? -2.008  -44.943 -2.363  1.000 44.850  0 706 HOH A O   1 
HETATM 3462 O O   . HOH D 4 .   ? 11.420  -66.315 11.041  1.000 35.660  0 707 HOH A O   1 
HETATM 3463 O O   . HOH D 4 .   ? 42.881  -32.080 2.239   1.000 46.930  0 708 HOH A O   1 
HETATM 3464 O O   . HOH D 4 .   ? 27.479  -17.906 3.864   1.000 50.680  0 709 HOH A O   1 
HETATM 3465 O O   . HOH D 4 .   ? 19.909  -62.706 16.642  1.000 29.470  0 710 HOH A O   1 
HETATM 3466 O O   . HOH D 4 .   ? 27.646  -49.648 18.116  1.000 39.140  0 711 HOH A O   1 
HETATM 3467 O O   . HOH D 4 .   ? 13.569  -56.959 24.718  1.000 36.800  0 712 HOH A O   1 
HETATM 3468 O O   . HOH D 4 .   ? 1.400   -60.163 9.297   1.000 45.380  0 713 HOH A O   1 
HETATM 3469 O O   . HOH D 4 .   ? 10.455  -38.734 22.452  1.000 47.400  0 714 HOH A O   1 
HETATM 3470 O O   . HOH D 4 .   ? 14.342  -39.428 0.348   1.000 39.880  0 715 HOH A O   1 
HETATM 3471 O O   . HOH D 4 .   ? 28.398  -59.065 7.538   1.000 41.700  0 716 HOH A O   1 
HETATM 3472 O O   . HOH D 4 .   ? 11.837  -43.234 9.673   1.000 32.170  0 717 HOH A O   1 
HETATM 3473 O O   . HOH D 4 .   ? 13.977  -33.689 13.686  1.000 52.890  0 718 HOH A O   1 
HETATM 3474 O O   . HOH D 4 .   ? 34.174  -51.182 4.275   1.000 31.930  0 719 HOH A O   1 
HETATM 3475 O O   . HOH D 4 .   ? 50.862  -49.787 6.091   1.000 34.720  0 720 HOH A O   1 
HETATM 3476 O O   . HOH D 4 .   ? 11.016  -47.777 -1.117  1.000 37.340  0 721 HOH A O   1 
HETATM 3477 O O   . HOH D 4 .   ? 14.926  -41.667 -12.028 1.000 42.380  0 722 HOH A O   1 
HETATM 3478 O O   . HOH D 4 .   ? 30.867  -20.380 -1.878  1.000 48.950  0 723 HOH A O   1 
HETATM 3479 O O   . HOH D 4 .   ? 45.190  -31.581 -3.721  1.000 46.090  0 724 HOH A O   1 
HETATM 3480 O O   . HOH D 4 .   ? 7.301   -39.200 -0.277  1.000 50.320  0 725 HOH A O   1 
HETATM 3481 O O   . HOH D 4 .   ? 44.133  -33.749 -4.924  1.000 52.740  0 726 HOH A O   1 
HETATM 3482 O O   . HOH D 4 .   ? 16.315  -37.526 -5.987  1.000 41.720  0 727 HOH A O   1 
HETATM 3483 O O   . HOH D 4 .   ? 38.859  -49.231 -13.192 1.000 44.890  0 728 HOH A O   1 
HETATM 3484 O O   . HOH D 4 .   ? 12.351  -33.125 17.324  1.000 58.520  0 729 HOH A O   1 
HETATM 3485 O O   . HOH D 4 .   ? 31.748  -44.395 -9.599  1.000 40.480  0 730 HOH A O   1 
HETATM 3486 O O   . HOH D 4 .   ? 33.556  -22.331 12.992  1.000 43.280  0 731 HOH A O   1 
HETATM 3487 O O   . HOH D 4 .   ? -7.788  -42.011 18.678  1.000 54.070  0 732 HOH A O   1 
HETATM 3488 O O   . HOH D 4 .   ? 26.451  -55.480 1.170   1.000 32.310  0 733 HOH A O   1 
HETATM 3489 O O   . HOH D 4 .   ? -11.100 -48.786 8.446   1.000 47.560  0 734 HOH A O   1 
HETATM 3490 O O   . HOH D 4 .   ? 13.504  -15.896 -0.784  1.000 58.040  0 735 HOH A O   1 
HETATM 3491 O O   . HOH D 4 .   ? 45.783  -38.094 3.110   1.000 42.590  0 736 HOH A O   1 
HETATM 3492 O O   . HOH D 4 .   ? 52.991  -49.164 -3.411  1.000 37.430  0 737 HOH A O   1 
HETATM 3493 O O   . HOH D 4 .   ? 15.870  -23.687 5.019   1.000 42.690  0 738 HOH A O   1 
HETATM 3494 O O   . HOH D 4 .   ? 10.501  -37.895 -2.991  1.000 43.760  0 739 HOH A O   1 
HETATM 3495 O O   . HOH D 4 .   ? 19.316  -33.517 8.349   1.000 40.640  0 740 HOH A O   1 
HETATM 3496 O O   . HOH D 4 .   ? 28.581  -53.737 -1.268  1.000 37.370  0 741 HOH A O   1 
HETATM 3497 O O   . HOH D 4 .   ? 37.166  -49.148 -7.943  1.000 35.570  0 742 HOH A O   1 
HETATM 3498 O O   . HOH D 4 .   ? 61.961  -51.175 -5.334  1.000 47.740  0 743 HOH A O   1 
HETATM 3499 O O   . HOH D 4 .   ? -0.659  -60.586 17.542  1.000 46.560  0 744 HOH A O   1 
HETATM 3500 O O   . HOH D 4 .   ? 43.308  -36.734 4.886   1.000 37.200  0 745 HOH A O   1 
HETATM 3501 O O   . HOH D 4 .   ? 9.224   -66.903 15.737  1.000 70.320  0 746 HOH A O   1 
HETATM 3502 O O   . HOH D 4 .   ? 21.141  -17.371 -2.896  1.000 54.530  0 747 HOH A O   1 
HETATM 3503 O O   . HOH D 4 .   ? 8.198   -39.781 -7.906  1.000 48.740  0 748 HOH A O   1 
HETATM 3504 O O   . HOH D 4 .   ? 14.473  -37.244 6.393   1.000 53.380  0 749 HOH A O   1 
HETATM 3505 O O   . HOH D 4 .   ? 37.376  -36.619 -12.661 1.000 42.230  0 750 HOH A O   1 
HETATM 3506 O O   . HOH D 4 .   ? 27.669  -49.329 -19.194 1.000 51.010  0 751 HOH A O   1 
HETATM 3507 O O   . HOH D 4 .   ? 11.759  -45.141 -11.226 1.000 49.480  0 752 HOH A O   1 
HETATM 3508 O O   . HOH D 4 .   ? 26.757  -30.417 -24.117 1.000 55.690  0 753 HOH A O   1 
HETATM 3509 O O   . HOH D 4 .   ? 40.237  -31.105 5.469   1.000 42.940  0 754 HOH A O   1 
HETATM 3510 O O   . HOH D 4 .   ? 23.438  -20.785 -10.611 1.000 51.790  0 755 HOH A O   1 
HETATM 3511 O O   . HOH D 4 .   ? 64.312  -56.897 -6.148  1.000 39.870  0 756 HOH A O   1 
HETATM 3512 O O   . HOH D 4 .   ? -6.961  -43.886 16.778  1.000 49.920  0 757 HOH A O   1 
HETATM 3513 O O   . HOH D 4 .   ? 25.133  -35.516 6.456   1.000 45.830  0 758 HOH A O   1 
HETATM 3514 O O   . HOH D 4 .   ? 50.679  -42.911 3.890   1.000 47.370  0 759 HOH A O   1 
HETATM 3515 O O   . HOH D 4 .   ? 33.299  -49.398 -8.959  1.000 35.260  0 760 HOH A O   1 
HETATM 3516 O O   . HOH D 4 .   ? 25.530  -19.240 -17.115 1.000 62.820  0 761 HOH A O   1 
HETATM 3517 O O   . HOH D 4 .   ? 47.285  -54.926 -12.590 1.000 68.280  0 762 HOH A O   1 
HETATM 3518 O O   . HOH D 4 .   ? 18.780  -25.367 11.493  1.000 45.850  0 763 HOH A O   1 
HETATM 3519 O O   . HOH D 4 .   ? 58.790  -60.496 -8.095  1.000 42.070  0 764 HOH A O   1 
HETATM 3520 O O   . HOH D 4 .   ? 27.015  -38.541 -24.627 1.000 57.640  0 765 HOH A O   1 
HETATM 3521 O O   . HOH D 4 .   ? 17.189  -27.477 10.363  1.000 46.250  0 766 HOH A O   1 
HETATM 3522 O O   . HOH D 4 .   ? 23.795  -38.137 0.272   1.000 45.870  0 767 HOH A O   1 
HETATM 3523 O O   . HOH D 4 .   ? 13.411  -46.987 0.016   1.000 36.370  0 768 HOH A O   1 
HETATM 3524 O O   . HOH D 4 .   ? 13.076  -46.703 -13.297 1.000 51.670  0 769 HOH A O   1 
HETATM 3525 O O   . HOH D 4 .   ? 44.159  -25.475 -10.055 1.000 53.130  0 770 HOH A O   1 
HETATM 3526 O O   . HOH D 4 .   ? 34.012  -46.054 -8.895  1.000 40.720  0 771 HOH A O   1 
HETATM 3527 O O   . HOH D 4 .   ? 9.371   -36.063 -1.634  1.000 47.620  0 772 HOH A O   1 
HETATM 3528 O O   . HOH D 4 .   ? -8.370  -48.217 9.029   1.000 51.490  0 773 HOH A O   1 
HETATM 3529 O O   . HOH D 4 .   ? 51.398  -45.781 -2.378  1.000 41.460  0 774 HOH A O   1 
HETATM 3530 O O   . HOH D 4 .   ? 59.383  -48.527 -3.269  1.000 68.160  0 775 HOH A O   1 
HETATM 3531 O O   . HOH D 4 .   ? 55.490  -50.173 -10.824 1.000 48.920  0 776 HOH A O   1 
HETATM 3532 O O   . HOH D 4 .   ? 17.413  -42.686 -11.334 1.000 43.160  0 777 HOH A O   1 
HETATM 3533 O O   . HOH D 4 .   ? 35.618  -43.758 -7.817  1.000 48.650  0 778 HOH A O   1 
HETATM 3534 O O   . HOH D 4 .   ? 22.069  -38.224 19.254  0.500 51.960  0 779 HOH A O   1 
HETATM 3535 O O   . HOH D 4 .   ? 35.597  -48.875 -10.322 1.000 36.520  0 780 HOH A O   1 
HETATM 3536 O O   . HOH D 4 .   ? 44.239  -35.160 -11.512 1.000 52.940  0 781 HOH A O   1 
HETATM 3537 O O   . HOH D 4 .   ? 11.202  -42.621 -16.391 1.000 55.180  0 782 HOH A O   1 
HETATM 3538 O O   . HOH D 4 .   ? 35.267  -47.380 -15.334 1.000 72.980  0 783 HOH A O   1 
HETATM 3539 O O   . HOH D 4 .   ? 21.079  -19.926 -11.867 1.000 51.340  0 784 HOH A O   1 
HETATM 3540 O O   . HOH D 4 .   ? 45.666  -37.668 12.409  1.000 59.240  0 785 HOH A O   1 
HETATM 3541 O O   . HOH D 4 .   ? 6.398   -33.588 13.207  1.000 55.680  0 786 HOH A O   1 
HETATM 3542 O O   . HOH D 4 .   ? 34.191  -44.486 -16.620 1.000 69.600  0 787 HOH A O   1 
HETATM 3543 O O   . HOH D 4 .   ? 40.991  -56.827 -13.510 1.000 60.280  0 788 HOH A O   1 
HETATM 3544 O O   . HOH D 4 .   ? 11.181  -58.138 5.066   1.000 39.900  0 789 HOH A O   1 
HETATM 3545 O O   . HOH D 4 .   ? 13.529  -17.454 1.726   1.000 58.860  0 790 HOH A O   1 
HETATM 3546 O O   . HOH D 4 .   ? 37.016  -59.807 -3.711  1.000 33.580  0 791 HOH A O   1 
HETATM 3547 O O   . HOH D 4 .   ? 25.891  -36.602 -23.211 1.000 52.170  0 792 HOH A O   1 
HETATM 3548 O O   . HOH D 4 .   ? 6.400   -59.467 5.097   1.000 53.730  0 793 HOH A O   1 
HETATM 3549 O O   . HOH D 4 .   ? 7.240   -62.452 3.972   1.000 59.850  0 794 HOH A O   1 
HETATM 3550 O O   . HOH D 4 .   ? 48.029  -45.168 -11.088 1.000 59.360  0 795 HOH A O   1 
HETATM 3551 O O   . HOH D 4 .   ? 56.943  -48.598 3.039   1.000 40.470  0 796 HOH A O   1 
HETATM 3552 O O   . HOH D 4 .   ? 22.590  -60.025 18.057  1.000 42.590  0 797 HOH A O   1 
HETATM 3553 O O   . HOH D 4 .   ? 26.461  -36.753 12.104  1.000 46.600  0 798 HOH A O   1 
HETATM 3554 O O   . HOH D 4 .   ? 1.942   -54.774 23.913  1.000 40.960  0 799 HOH A O   1 
HETATM 3555 O O   . HOH D 4 .   ? 38.447  -23.262 0.368   1.000 56.000  0 800 HOH A O   1 
HETATM 3556 O O   . HOH D 4 .   ? 40.907  -31.648 -15.355 1.000 55.880  0 801 HOH A O   1 
HETATM 3557 O O   . HOH D 4 .   ? 55.720  -41.010 9.221   1.000 65.730  0 802 HOH A O   1 
HETATM 3558 O O   . HOH D 4 .   ? 56.348  -54.816 2.338   1.000 41.990  0 803 HOH A O   1 
HETATM 3559 O O   . HOH D 4 .   ? 31.844  -59.573 -9.971  1.000 62.650  0 804 HOH A O   1 
HETATM 3560 O O   . HOH D 4 .   ? 26.210  -21.038 -8.258  1.000 50.950  0 805 HOH A O   1 
HETATM 3561 O O   . HOH D 4 .   ? 27.491  -21.272 -17.988 1.000 63.970  0 806 HOH A O   1 
HETATM 3562 O O   . HOH D 4 .   ? -1.159  -62.590 11.292  1.000 64.950  0 807 HOH A O   1 
HETATM 3563 O O   . HOH D 4 .   ? 32.336  -57.645 -8.212  1.000 50.340  0 808 HOH A O   1 
HETATM 3564 O O   . HOH D 4 .   ? -8.844  -48.029 23.153  1.000 61.440  0 809 HOH A O   1 
HETATM 3565 O O   . HOH D 4 .   ? 1.962   -43.036 25.553  1.000 46.990  0 810 HOH A O   1 
HETATM 3566 O O   . HOH D 4 .   ? 26.240  -39.405 13.005  1.000 50.240  0 811 HOH A O   1 
HETATM 3567 O O   . HOH D 4 .   ? 1.504   -46.653 26.912  1.000 42.520  0 812 HOH A O   1 
HETATM 3568 O O   . HOH D 4 .   ? 10.842  -36.682 0.643   1.000 37.580  0 813 HOH A O   1 
HETATM 3569 O O   . HOH D 4 .   ? 14.764  -36.121 17.095  1.000 55.870  0 814 HOH A O   1 
HETATM 3570 O O   . HOH D 4 .   ? 9.734   -19.077 6.302   1.000 60.600  0 815 HOH A O   1 
HETATM 3571 O O   . HOH D 4 .   ? 1.226   -53.319 2.107   1.000 45.500  0 816 HOH A O   1 
HETATM 3572 O O   . HOH D 4 .   ? 39.120  -25.121 6.352   1.000 49.890  0 817 HOH A O   1 
HETATM 3573 O O   . HOH D 4 .   ? 8.149   -61.080 6.248   1.000 40.430  0 818 HOH A O   1 
HETATM 3574 O O   . HOH D 4 .   ? 10.875  -40.812 24.533  1.000 49.570  0 819 HOH A O   1 
HETATM 3575 O O   . HOH D 4 .   ? -5.257  -50.376 6.140   1.000 61.090  0 820 HOH A O   1 
HETATM 3576 O O   . HOH D 4 .   ? 9.133   -45.103 -15.504 1.000 54.120  0 821 HOH A O   1 
HETATM 3577 O O   . HOH D 4 .   ? 8.113   -61.813 22.697  1.000 76.690  0 822 HOH A O   1 
HETATM 3578 O O   . HOH D 4 .   ? -7.890  -50.897 9.817   1.000 50.150  0 823 HOH A O   1 
HETATM 3579 O O   . HOH D 4 .   ? 23.448  -49.336 -18.581 1.000 53.340  0 824 HOH A O   1 
HETATM 3580 O O   . HOH D 4 .   ? 4.481   -35.235 4.682   1.000 67.000  0 825 HOH A O   1 
HETATM 3581 O O   . HOH D 4 .   ? 12.790  -62.710 20.261  1.000 67.660  0 826 HOH A O   1 
HETATM 3582 O O   . HOH D 4 .   ? 15.133  -13.993 3.206   1.000 71.610  0 827 HOH A O   1 
HETATM 3583 O O   . HOH D 4 .   ? 18.567  -50.904 -2.236  1.000 49.280  0 828 HOH A O   1 
HETATM 3584 O O   . HOH D 4 .   ? 23.992  -38.074 4.848   1.000 44.980  0 829 HOH A O   1 
HETATM 3585 O O   . HOH D 4 .   ? 62.778  -54.529 -5.430  1.000 39.000  0 830 HOH A O   1 
HETATM 3586 O O   . HOH D 4 .   ? 59.625  -49.975 -0.842  1.000 63.970  0 831 HOH A O   1 
HETATM 3587 O O   . HOH D 4 .   ? 22.124  -21.449 -19.845 1.000 55.840  0 832 HOH A O   1 
HETATM 3588 O O   . HOH D 4 .   ? 14.406  -48.239 -6.725  1.000 47.740  0 833 HOH A O   1 
HETATM 3589 O O   . HOH D 4 .   ? 9.928   -50.172 -23.701 1.000 71.120  0 834 HOH A O   1 
HETATM 3590 O O   . HOH D 4 .   ? 27.081  -52.842 -8.691  1.000 55.670  0 835 HOH A O   1 
HETATM 3591 O O   . HOH D 4 .   ? 11.931  -58.891 24.718  1.000 45.060  0 836 HOH A O   1 
HETATM 3592 O O   . HOH D 4 .   ? 11.896  -38.724 -0.485  1.000 42.280  0 837 HOH A O   1 
HETATM 3593 O O   . HOH D 4 .   ? 33.660  -61.622 -9.956  1.000 45.550  0 838 HOH A O   1 
HETATM 3594 O O   . HOH D 4 .   ? 14.243  -15.841 4.720   1.000 60.280  0 839 HOH A O   1 
HETATM 3595 O O   . HOH D 4 .   ? 3.575   -24.899 -2.686  1.000 69.200  0 840 HOH A O   1 
HETATM 3596 O O   . HOH D 4 .   ? 0.346   -63.975 12.751  1.000 62.500  0 841 HOH A O   1 
HETATM 3597 O O   . HOH D 4 .   ? 44.933  -56.977 -11.150 1.000 72.610  0 842 HOH A O   1 
HETATM 3598 O O   . HOH D 4 .   ? 18.070  -32.851 17.180  1.000 79.550  0 843 HOH A O   1 
HETATM 3599 O O   . HOH D 4 .   ? 48.533  -39.409 3.876   1.000 56.030  0 844 HOH A O   1 
HETATM 3600 O O   . HOH D 4 .   ? 24.493  -59.446 20.226  1.000 58.050  0 845 HOH A O   1 
HETATM 3601 O O   . HOH D 4 .   ? 63.153  -54.858 -2.261  1.000 46.470  0 846 HOH A O   1 
HETATM 3602 O O   . HOH D 4 .   ? 25.393  -12.648 -2.926  1.000 67.860  0 847 HOH A O   1 
HETATM 3603 O O   . HOH D 4 .   ? 52.489  -64.237 -10.689 1.000 45.760  0 848 HOH A O   1 
HETATM 3604 O O   . HOH D 4 .   ? 44.467  -34.470 5.569   1.000 45.970  0 849 HOH A O   1 
HETATM 3605 O O   . HOH D 4 .   ? 28.010  -11.988 7.404   1.000 76.850  0 850 HOH A O   1 
HETATM 3606 O O   . HOH D 4 .   ? 40.568  -27.499 6.542   1.000 56.310  0 851 HOH A O   1 
HETATM 3607 O O   . HOH D 4 .   ? 33.622  -55.724 10.775  1.000 52.000  0 852 HOH A O   1 
HETATM 3608 O O   . HOH D 4 .   ? 31.994  -59.290 4.736   1.000 35.260  0 853 HOH A O   1 
HETATM 3609 O O   . HOH D 4 .   ? 21.573  -17.040 -12.616 1.000 66.200  0 854 HOH A O   1 
HETATM 3610 O O   . HOH D 4 .   ? 46.020  -35.168 -5.267  1.000 63.720  0 855 HOH A O   1 
HETATM 3611 O O   . HOH D 4 .   ? 17.025  -36.380 -25.800 1.000 61.220  0 856 HOH A O   1 
HETATM 3612 O O   . HOH D 4 .   ? 12.723  -41.847 -13.960 1.000 49.420  0 857 HOH A O   1 
HETATM 3613 O O   . HOH D 4 .   ? 23.556  -19.795 -19.397 1.000 70.720  0 858 HOH A O   1 
HETATM 3614 O O   . HOH D 4 .   ? 17.393  -51.031 -4.577  1.000 50.150  0 859 HOH A O   1 
HETATM 3615 O O   . HOH D 4 .   ? 0.391   -39.548 26.833  1.000 53.090  0 860 HOH A O   1 
HETATM 3616 O O   . HOH D 4 .   ? 43.394  -33.583 7.496   1.000 62.940  0 861 HOH A O   1 
HETATM 3617 O O   . HOH D 4 .   ? -9.875  -46.592 13.864  1.000 61.120  0 862 HOH A O   1 
HETATM 3618 O O   . HOH D 4 .   ? -10.641 -52.182 22.879  1.000 65.580  0 863 HOH A O   1 
HETATM 3619 O O   . HOH D 4 .   ? 23.678  -52.326 -5.797  1.000 47.490  0 864 HOH A O   1 
HETATM 3620 O O   . HOH D 4 .   ? 65.403  -56.122 -2.623  1.000 68.860  0 865 HOH A O   1 
HETATM 3621 O O   . HOH D 4 .   ? 29.318  -20.569 -19.963 1.000 64.570  0 866 HOH A O   1 
HETATM 3622 O O   . HOH D 4 .   ? 11.462  -66.708 13.854  1.000 56.680  0 867 HOH A O   1 
HETATM 3623 O O   . HOH D 4 .   ? -7.280  -46.967 24.997  1.000 72.640  0 868 HOH A O   1 
HETATM 3624 O O   . HOH D 4 .   ? 19.194  -31.006 18.534  1.000 74.000  0 869 HOH A O   1 
HETATM 3625 O O   . HOH D 4 .   ? 18.281  -29.970 11.665  1.000 46.790  0 870 HOH A O   1 
HETATM 3626 O O   . HOH D 4 .   ? -2.481  -58.860 16.288  1.000 59.160  0 871 HOH A O   1 
HETATM 3627 O O   . HOH D 4 .   ? 47.814  -51.056 -13.868 1.000 62.570  0 872 HOH A O   1 
HETATM 3628 O O   . HOH D 4 .   ? 40.843  -33.841 -13.993 1.000 47.590  0 873 HOH A O   1 
HETATM 3629 O O   . HOH D 4 .   ? 44.198  -55.787 -12.951 1.000 81.970  0 874 HOH A O   1 
HETATM 3630 O O   . HOH D 4 .   ? 1.582   -55.373 1.308   1.000 50.790  0 875 HOH A O   1 
HETATM 3631 O O   . HOH D 4 .   ? -6.410  -44.890 23.516  1.000 63.270  0 876 HOH A O   1 
HETATM 3632 O O   . HOH D 4 .   ? 43.622  -34.041 -13.674 1.000 60.860  0 877 HOH A O   1 
HETATM 3633 O O   . HOH D 4 .   ? 44.478  -32.960 3.662   1.000 67.160  0 878 HOH A O   1 
HETATM 3634 O O   . HOH D 4 .   ? 9.545   -54.522 -22.564 1.000 64.360  0 879 HOH A O   1 
HETATM 3635 O O   . HOH D 4 .   ? 34.468  -58.115 4.750   1.000 34.370  0 880 HOH A O   1 
HETATM 3636 O O   . HOH D 4 .   ? 15.003  -62.903 19.627  1.000 62.470  0 881 HOH A O   1 
HETATM 3637 O O   . HOH D 4 .   ? 38.021  -21.986 9.016   1.000 55.000  0 882 HOH A O   1 
HETATM 3638 O O   . HOH D 4 .   ? 49.705  -45.149 14.745  1.000 49.970  0 883 HOH A O   1 
HETATM 3639 O O   . HOH D 4 .   ? 17.709  -63.834 18.213  1.000 39.010  0 884 HOH A O   1 
HETATM 3640 O O   . HOH D 4 .   ? 17.261  -24.260 13.324  1.000 56.120  0 885 HOH A O   1 
HETATM 3641 O O   . HOH D 4 .   ? 39.866  -35.773 -12.011 1.000 56.420  0 886 HOH A O   1 
HETATM 3642 O O   . HOH D 4 .   ? 27.448  -9.972  6.400   1.000 73.420  0 887 HOH A O   1 
# 
