data_8WS6
# 
_entry.id   8WS6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8WS6         pdb_00008ws6 10.2210/pdb8ws6/pdb 
WWPDB D_1300041535 ?            ?                   
EMDB  EMD-37799    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-16 ? 
2 'EM metadata'     1 0 2025-04-16 ? 
3 'Half map'        1 0 2025-04-16 1 
4 'Half map'        1 0 2025-04-16 2 
5 Image             1 0 2025-04-16 ? 
6 'Primary map'     1 0 2025-04-16 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8WS6 
_pdbx_database_status.recvd_initial_deposition_date   2023-10-16 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM mini structure of Cas12-1 with 14 nt complementary heteroduplex' 
_pdbx_database_related.db_id          EMD-37799 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              zhangk@sustech.edu.cn 
_pdbx_contact_author.name_first         Zhang 
_pdbx_contact_author.name_last          Kuo 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2875-2581 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kuo, Z.' 1 ? 
'Xi, Z.'  2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM mini structure of Cas12-1 with 14 nt complementary heteroduplex' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kuo, Z.' 1 ? 
primary 'Xi, Z.'  2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Cas12-1 83449.094 1 ? ? ? ? 
2 polymer man TS      12990.339 1 ? ? ? ? 
3 polymer man crRNA   14652.684 1 ? ? ? ? 
4 polymer man NTS     12874.237 1 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'        no no 
;MTPKTETPVGALIKKFFPGKRFQKNYLKDAGKKLKREGEAAAVEYLSGKQEDHPANFCPPAKVNILAQSRPLSEWPINLV
SKGVQEYVYGLTAAEREANGDFGTSRKSLDRWFARTGVPTHGYTTVQGLNLILRHTFNRYDGVIKKVETRNEKRRSKATR
INVSREADGLPPIEAEPEETAFGPDGKLKERPGINPSIYCYQQVSPVPYNPAKHPALPFSGVDPGAPLPLGTPNRLSIPK
GQPGYVPEWQRPHLSTKNKRIRKWYARANWRRKPGRKSVLDEAKLKEAALKEAIPIIVTIGKDWIVMDARGLLRAVYWRG
IAKPGLSLKELLGFFSGDPVLDPKRGIATFTFKLGAVAVHSRKPTRGKKSKELLLSMTAEKPHVGLVAIDLGQTNPVAAE
FSRVKREGETLQAEPLGQIVLPDDLVKDLTRYRRAWDATEEQIKAEAIVQLPEECRAEVVKVNQMSAEETKHLILDRGVS
GDLPWEKMTSNTTFISDHLLAKGVTDQVFFEKKSKGKKKGTETVKRKDYGWVKLLRPRLSQETRKAVNDKTWELKRASTE
YVRLSRRKTELARRCVNYIVRETKRWTQCEDIAIVIEDLNVRFFHGSGERPDGWDNFFISKRENRWFIQVLHKAFSDLAL
HRGLPVIEANPARTSITCIRCGHCDRNNRHGEMFLCLSCNDLRHADREIATRNLTRVAVTGEMIPRRIEPGEQSGDTKKA
RSARKGKKAVISKREAA
;
;MTPKTETPVGALIKKFFPGKRFQKNYLKDAGKKLKREGEAAAVEYLSGKQEDHPANFCPPAKVNILAQSRPLSEWPINLV
SKGVQEYVYGLTAAEREANGDFGTSRKSLDRWFARTGVPTHGYTTVQGLNLILRHTFNRYDGVIKKVETRNEKRRSKATR
INVSREADGLPPIEAEPEETAFGPDGKLKERPGINPSIYCYQQVSPVPYNPAKHPALPFSGVDPGAPLPLGTPNRLSIPK
GQPGYVPEWQRPHLSTKNKRIRKWYARANWRRKPGRKSVLDEAKLKEAALKEAIPIIVTIGKDWIVMDARGLLRAVYWRG
IAKPGLSLKELLGFFSGDPVLDPKRGIATFTFKLGAVAVHSRKPTRGKKSKELLLSMTAEKPHVGLVAIDLGQTNPVAAE
FSRVKREGETLQAEPLGQIVLPDDLVKDLTRYRRAWDATEEQIKAEAIVQLPEECRAEVVKVNQMSAEETKHLILDRGVS
GDLPWEKMTSNTTFISDHLLAKGVTDQVFFEKKSKGKKKGTETVKRKDYGWVKLLRPRLSQETRKAVNDKTWELKRASTE
YVRLSRRKTELARRCVNYIVRETKRWTQCEDIAIVIEDLNVRFFHGSGERPDGWDNFFISKRENRWFIQVLHKAFSDLAL
HRGLPVIEANPARTSITCIRCGHCDRNNRHGEMFLCLSCNDLRHADREIATRNLTRVAVTGEMIPRRIEPGEQSGDTKKA
RSARKGKKAVISKREAA
;
A ? 
2 polydeoxyribonucleotide no no 
;(DC)(DT)(DG)(DC)(DC)(DC)(DT)(DT)(DG)(DC)(DA)(DA)(DG)(DA)(DA)(DG)(DT)(DC)(DC)(DA)
(DG)(DC)(DA)(DC)(DG)(DT)(DA)(DG)(DG)(DG)(DG)(DA)(DG)(DA)(DA)(DT)(DT)(DG)(DG)(DC)
(DC)(DA)
;
CTGCCCTTGCAAGAAGTCCAGCACGTAGGGGAGAATTGGCCA C ? 
3 polyribonucleotide      no no UCAACGCUUGCUCGGUUCGCCGAGACUCCCCUACGUGCUGCUGAAG UCAACGCUUGCUCGGUUCGCCGAGACUCCCCUACGUGCUGCUGAAG B ? 
4 polydeoxyribonucleotide no no 
;(DT)(DG)(DG)(DC)(DC)(DA)(DA)(DT)(DT)(DC)(DT)(DC)(DC)(DC)(DC)(DT)(DA)(DC)(DG)(DT)
(DG)(DC)(DT)(DG)(DG)(DA)(DC)(DT)(DT)(DC)(DT)(DT)(DG)(DC)(DA)(DA)(DG)(DG)(DG)(DC)
(DA)(DG)
;
TGGCCAATTCTCCCCTACGTGCTGGACTTCTTGCAAGGGCAG D ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   THR n 
1 3   PRO n 
1 4   LYS n 
1 5   THR n 
1 6   GLU n 
1 7   THR n 
1 8   PRO n 
1 9   VAL n 
1 10  GLY n 
1 11  ALA n 
1 12  LEU n 
1 13  ILE n 
1 14  LYS n 
1 15  LYS n 
1 16  PHE n 
1 17  PHE n 
1 18  PRO n 
1 19  GLY n 
1 20  LYS n 
1 21  ARG n 
1 22  PHE n 
1 23  GLN n 
1 24  LYS n 
1 25  ASN n 
1 26  TYR n 
1 27  LEU n 
1 28  LYS n 
1 29  ASP n 
1 30  ALA n 
1 31  GLY n 
1 32  LYS n 
1 33  LYS n 
1 34  LEU n 
1 35  LYS n 
1 36  ARG n 
1 37  GLU n 
1 38  GLY n 
1 39  GLU n 
1 40  ALA n 
1 41  ALA n 
1 42  ALA n 
1 43  VAL n 
1 44  GLU n 
1 45  TYR n 
1 46  LEU n 
1 47  SER n 
1 48  GLY n 
1 49  LYS n 
1 50  GLN n 
1 51  GLU n 
1 52  ASP n 
1 53  HIS n 
1 54  PRO n 
1 55  ALA n 
1 56  ASN n 
1 57  PHE n 
1 58  CYS n 
1 59  PRO n 
1 60  PRO n 
1 61  ALA n 
1 62  LYS n 
1 63  VAL n 
1 64  ASN n 
1 65  ILE n 
1 66  LEU n 
1 67  ALA n 
1 68  GLN n 
1 69  SER n 
1 70  ARG n 
1 71  PRO n 
1 72  LEU n 
1 73  SER n 
1 74  GLU n 
1 75  TRP n 
1 76  PRO n 
1 77  ILE n 
1 78  ASN n 
1 79  LEU n 
1 80  VAL n 
1 81  SER n 
1 82  LYS n 
1 83  GLY n 
1 84  VAL n 
1 85  GLN n 
1 86  GLU n 
1 87  TYR n 
1 88  VAL n 
1 89  TYR n 
1 90  GLY n 
1 91  LEU n 
1 92  THR n 
1 93  ALA n 
1 94  ALA n 
1 95  GLU n 
1 96  ARG n 
1 97  GLU n 
1 98  ALA n 
1 99  ASN n 
1 100 GLY n 
1 101 ASP n 
1 102 PHE n 
1 103 GLY n 
1 104 THR n 
1 105 SER n 
1 106 ARG n 
1 107 LYS n 
1 108 SER n 
1 109 LEU n 
1 110 ASP n 
1 111 ARG n 
1 112 TRP n 
1 113 PHE n 
1 114 ALA n 
1 115 ARG n 
1 116 THR n 
1 117 GLY n 
1 118 VAL n 
1 119 PRO n 
1 120 THR n 
1 121 HIS n 
1 122 GLY n 
1 123 TYR n 
1 124 THR n 
1 125 THR n 
1 126 VAL n 
1 127 GLN n 
1 128 GLY n 
1 129 LEU n 
1 130 ASN n 
1 131 LEU n 
1 132 ILE n 
1 133 LEU n 
1 134 ARG n 
1 135 HIS n 
1 136 THR n 
1 137 PHE n 
1 138 ASN n 
1 139 ARG n 
1 140 TYR n 
1 141 ASP n 
1 142 GLY n 
1 143 VAL n 
1 144 ILE n 
1 145 LYS n 
1 146 LYS n 
1 147 VAL n 
1 148 GLU n 
1 149 THR n 
1 150 ARG n 
1 151 ASN n 
1 152 GLU n 
1 153 LYS n 
1 154 ARG n 
1 155 ARG n 
1 156 SER n 
1 157 LYS n 
1 158 ALA n 
1 159 THR n 
1 160 ARG n 
1 161 ILE n 
1 162 ASN n 
1 163 VAL n 
1 164 SER n 
1 165 ARG n 
1 166 GLU n 
1 167 ALA n 
1 168 ASP n 
1 169 GLY n 
1 170 LEU n 
1 171 PRO n 
1 172 PRO n 
1 173 ILE n 
1 174 GLU n 
1 175 ALA n 
1 176 GLU n 
1 177 PRO n 
1 178 GLU n 
1 179 GLU n 
1 180 THR n 
1 181 ALA n 
1 182 PHE n 
1 183 GLY n 
1 184 PRO n 
1 185 ASP n 
1 186 GLY n 
1 187 LYS n 
1 188 LEU n 
1 189 LYS n 
1 190 GLU n 
1 191 ARG n 
1 192 PRO n 
1 193 GLY n 
1 194 ILE n 
1 195 ASN n 
1 196 PRO n 
1 197 SER n 
1 198 ILE n 
1 199 TYR n 
1 200 CYS n 
1 201 TYR n 
1 202 GLN n 
1 203 GLN n 
1 204 VAL n 
1 205 SER n 
1 206 PRO n 
1 207 VAL n 
1 208 PRO n 
1 209 TYR n 
1 210 ASN n 
1 211 PRO n 
1 212 ALA n 
1 213 LYS n 
1 214 HIS n 
1 215 PRO n 
1 216 ALA n 
1 217 LEU n 
1 218 PRO n 
1 219 PHE n 
1 220 SER n 
1 221 GLY n 
1 222 VAL n 
1 223 ASP n 
1 224 PRO n 
1 225 GLY n 
1 226 ALA n 
1 227 PRO n 
1 228 LEU n 
1 229 PRO n 
1 230 LEU n 
1 231 GLY n 
1 232 THR n 
1 233 PRO n 
1 234 ASN n 
1 235 ARG n 
1 236 LEU n 
1 237 SER n 
1 238 ILE n 
1 239 PRO n 
1 240 LYS n 
1 241 GLY n 
1 242 GLN n 
1 243 PRO n 
1 244 GLY n 
1 245 TYR n 
1 246 VAL n 
1 247 PRO n 
1 248 GLU n 
1 249 TRP n 
1 250 GLN n 
1 251 ARG n 
1 252 PRO n 
1 253 HIS n 
1 254 LEU n 
1 255 SER n 
1 256 THR n 
1 257 LYS n 
1 258 ASN n 
1 259 LYS n 
1 260 ARG n 
1 261 ILE n 
1 262 ARG n 
1 263 LYS n 
1 264 TRP n 
1 265 TYR n 
1 266 ALA n 
1 267 ARG n 
1 268 ALA n 
1 269 ASN n 
1 270 TRP n 
1 271 ARG n 
1 272 ARG n 
1 273 LYS n 
1 274 PRO n 
1 275 GLY n 
1 276 ARG n 
1 277 LYS n 
1 278 SER n 
1 279 VAL n 
1 280 LEU n 
1 281 ASP n 
1 282 GLU n 
1 283 ALA n 
1 284 LYS n 
1 285 LEU n 
1 286 LYS n 
1 287 GLU n 
1 288 ALA n 
1 289 ALA n 
1 290 LEU n 
1 291 LYS n 
1 292 GLU n 
1 293 ALA n 
1 294 ILE n 
1 295 PRO n 
1 296 ILE n 
1 297 ILE n 
1 298 VAL n 
1 299 THR n 
1 300 ILE n 
1 301 GLY n 
1 302 LYS n 
1 303 ASP n 
1 304 TRP n 
1 305 ILE n 
1 306 VAL n 
1 307 MET n 
1 308 ASP n 
1 309 ALA n 
1 310 ARG n 
1 311 GLY n 
1 312 LEU n 
1 313 LEU n 
1 314 ARG n 
1 315 ALA n 
1 316 VAL n 
1 317 TYR n 
1 318 TRP n 
1 319 ARG n 
1 320 GLY n 
1 321 ILE n 
1 322 ALA n 
1 323 LYS n 
1 324 PRO n 
1 325 GLY n 
1 326 LEU n 
1 327 SER n 
1 328 LEU n 
1 329 LYS n 
1 330 GLU n 
1 331 LEU n 
1 332 LEU n 
1 333 GLY n 
1 334 PHE n 
1 335 PHE n 
1 336 SER n 
1 337 GLY n 
1 338 ASP n 
1 339 PRO n 
1 340 VAL n 
1 341 LEU n 
1 342 ASP n 
1 343 PRO n 
1 344 LYS n 
1 345 ARG n 
1 346 GLY n 
1 347 ILE n 
1 348 ALA n 
1 349 THR n 
1 350 PHE n 
1 351 THR n 
1 352 PHE n 
1 353 LYS n 
1 354 LEU n 
1 355 GLY n 
1 356 ALA n 
1 357 VAL n 
1 358 ALA n 
1 359 VAL n 
1 360 HIS n 
1 361 SER n 
1 362 ARG n 
1 363 LYS n 
1 364 PRO n 
1 365 THR n 
1 366 ARG n 
1 367 GLY n 
1 368 LYS n 
1 369 LYS n 
1 370 SER n 
1 371 LYS n 
1 372 GLU n 
1 373 LEU n 
1 374 LEU n 
1 375 LEU n 
1 376 SER n 
1 377 MET n 
1 378 THR n 
1 379 ALA n 
1 380 GLU n 
1 381 LYS n 
1 382 PRO n 
1 383 HIS n 
1 384 VAL n 
1 385 GLY n 
1 386 LEU n 
1 387 VAL n 
1 388 ALA n 
1 389 ILE n 
1 390 ASP n 
1 391 LEU n 
1 392 GLY n 
1 393 GLN n 
1 394 THR n 
1 395 ASN n 
1 396 PRO n 
1 397 VAL n 
1 398 ALA n 
1 399 ALA n 
1 400 GLU n 
1 401 PHE n 
1 402 SER n 
1 403 ARG n 
1 404 VAL n 
1 405 LYS n 
1 406 ARG n 
1 407 GLU n 
1 408 GLY n 
1 409 GLU n 
1 410 THR n 
1 411 LEU n 
1 412 GLN n 
1 413 ALA n 
1 414 GLU n 
1 415 PRO n 
1 416 LEU n 
1 417 GLY n 
1 418 GLN n 
1 419 ILE n 
1 420 VAL n 
1 421 LEU n 
1 422 PRO n 
1 423 ASP n 
1 424 ASP n 
1 425 LEU n 
1 426 VAL n 
1 427 LYS n 
1 428 ASP n 
1 429 LEU n 
1 430 THR n 
1 431 ARG n 
1 432 TYR n 
1 433 ARG n 
1 434 ARG n 
1 435 ALA n 
1 436 TRP n 
1 437 ASP n 
1 438 ALA n 
1 439 THR n 
1 440 GLU n 
1 441 GLU n 
1 442 GLN n 
1 443 ILE n 
1 444 LYS n 
1 445 ALA n 
1 446 GLU n 
1 447 ALA n 
1 448 ILE n 
1 449 VAL n 
1 450 GLN n 
1 451 LEU n 
1 452 PRO n 
1 453 GLU n 
1 454 GLU n 
1 455 CYS n 
1 456 ARG n 
1 457 ALA n 
1 458 GLU n 
1 459 VAL n 
1 460 VAL n 
1 461 LYS n 
1 462 VAL n 
1 463 ASN n 
1 464 GLN n 
1 465 MET n 
1 466 SER n 
1 467 ALA n 
1 468 GLU n 
1 469 GLU n 
1 470 THR n 
1 471 LYS n 
1 472 HIS n 
1 473 LEU n 
1 474 ILE n 
1 475 LEU n 
1 476 ASP n 
1 477 ARG n 
1 478 GLY n 
1 479 VAL n 
1 480 SER n 
1 481 GLY n 
1 482 ASP n 
1 483 LEU n 
1 484 PRO n 
1 485 TRP n 
1 486 GLU n 
1 487 LYS n 
1 488 MET n 
1 489 THR n 
1 490 SER n 
1 491 ASN n 
1 492 THR n 
1 493 THR n 
1 494 PHE n 
1 495 ILE n 
1 496 SER n 
1 497 ASP n 
1 498 HIS n 
1 499 LEU n 
1 500 LEU n 
1 501 ALA n 
1 502 LYS n 
1 503 GLY n 
1 504 VAL n 
1 505 THR n 
1 506 ASP n 
1 507 GLN n 
1 508 VAL n 
1 509 PHE n 
1 510 PHE n 
1 511 GLU n 
1 512 LYS n 
1 513 LYS n 
1 514 SER n 
1 515 LYS n 
1 516 GLY n 
1 517 LYS n 
1 518 LYS n 
1 519 LYS n 
1 520 GLY n 
1 521 THR n 
1 522 GLU n 
1 523 THR n 
1 524 VAL n 
1 525 LYS n 
1 526 ARG n 
1 527 LYS n 
1 528 ASP n 
1 529 TYR n 
1 530 GLY n 
1 531 TRP n 
1 532 VAL n 
1 533 LYS n 
1 534 LEU n 
1 535 LEU n 
1 536 ARG n 
1 537 PRO n 
1 538 ARG n 
1 539 LEU n 
1 540 SER n 
1 541 GLN n 
1 542 GLU n 
1 543 THR n 
1 544 ARG n 
1 545 LYS n 
1 546 ALA n 
1 547 VAL n 
1 548 ASN n 
1 549 ASP n 
1 550 LYS n 
1 551 THR n 
1 552 TRP n 
1 553 GLU n 
1 554 LEU n 
1 555 LYS n 
1 556 ARG n 
1 557 ALA n 
1 558 SER n 
1 559 THR n 
1 560 GLU n 
1 561 TYR n 
1 562 VAL n 
1 563 ARG n 
1 564 LEU n 
1 565 SER n 
1 566 ARG n 
1 567 ARG n 
1 568 LYS n 
1 569 THR n 
1 570 GLU n 
1 571 LEU n 
1 572 ALA n 
1 573 ARG n 
1 574 ARG n 
1 575 CYS n 
1 576 VAL n 
1 577 ASN n 
1 578 TYR n 
1 579 ILE n 
1 580 VAL n 
1 581 ARG n 
1 582 GLU n 
1 583 THR n 
1 584 LYS n 
1 585 ARG n 
1 586 TRP n 
1 587 THR n 
1 588 GLN n 
1 589 CYS n 
1 590 GLU n 
1 591 ASP n 
1 592 ILE n 
1 593 ALA n 
1 594 ILE n 
1 595 VAL n 
1 596 ILE n 
1 597 GLU n 
1 598 ASP n 
1 599 LEU n 
1 600 ASN n 
1 601 VAL n 
1 602 ARG n 
1 603 PHE n 
1 604 PHE n 
1 605 HIS n 
1 606 GLY n 
1 607 SER n 
1 608 GLY n 
1 609 GLU n 
1 610 ARG n 
1 611 PRO n 
1 612 ASP n 
1 613 GLY n 
1 614 TRP n 
1 615 ASP n 
1 616 ASN n 
1 617 PHE n 
1 618 PHE n 
1 619 ILE n 
1 620 SER n 
1 621 LYS n 
1 622 ARG n 
1 623 GLU n 
1 624 ASN n 
1 625 ARG n 
1 626 TRP n 
1 627 PHE n 
1 628 ILE n 
1 629 GLN n 
1 630 VAL n 
1 631 LEU n 
1 632 HIS n 
1 633 LYS n 
1 634 ALA n 
1 635 PHE n 
1 636 SER n 
1 637 ASP n 
1 638 LEU n 
1 639 ALA n 
1 640 LEU n 
1 641 HIS n 
1 642 ARG n 
1 643 GLY n 
1 644 LEU n 
1 645 PRO n 
1 646 VAL n 
1 647 ILE n 
1 648 GLU n 
1 649 ALA n 
1 650 ASN n 
1 651 PRO n 
1 652 ALA n 
1 653 ARG n 
1 654 THR n 
1 655 SER n 
1 656 ILE n 
1 657 THR n 
1 658 CYS n 
1 659 ILE n 
1 660 ARG n 
1 661 CYS n 
1 662 GLY n 
1 663 HIS n 
1 664 CYS n 
1 665 ASP n 
1 666 ARG n 
1 667 ASN n 
1 668 ASN n 
1 669 ARG n 
1 670 HIS n 
1 671 GLY n 
1 672 GLU n 
1 673 MET n 
1 674 PHE n 
1 675 LEU n 
1 676 CYS n 
1 677 LEU n 
1 678 SER n 
1 679 CYS n 
1 680 ASN n 
1 681 ASP n 
1 682 LEU n 
1 683 ARG n 
1 684 HIS n 
1 685 ALA n 
1 686 ASP n 
1 687 ARG n 
1 688 GLU n 
1 689 ILE n 
1 690 ALA n 
1 691 THR n 
1 692 ARG n 
1 693 ASN n 
1 694 LEU n 
1 695 THR n 
1 696 ARG n 
1 697 VAL n 
1 698 ALA n 
1 699 VAL n 
1 700 THR n 
1 701 GLY n 
1 702 GLU n 
1 703 MET n 
1 704 ILE n 
1 705 PRO n 
1 706 ARG n 
1 707 ARG n 
1 708 ILE n 
1 709 GLU n 
1 710 PRO n 
1 711 GLY n 
1 712 GLU n 
1 713 GLN n 
1 714 SER n 
1 715 GLY n 
1 716 ASP n 
1 717 THR n 
1 718 LYS n 
1 719 LYS n 
1 720 ALA n 
1 721 ARG n 
1 722 SER n 
1 723 ALA n 
1 724 ARG n 
1 725 LYS n 
1 726 GLY n 
1 727 LYS n 
1 728 LYS n 
1 729 ALA n 
1 730 VAL n 
1 731 ILE n 
1 732 SER n 
1 733 LYS n 
1 734 ARG n 
1 735 GLU n 
1 736 ALA n 
1 737 ALA n 
2 1   DC  n 
2 2   DT  n 
2 3   DG  n 
2 4   DC  n 
2 5   DC  n 
2 6   DC  n 
2 7   DT  n 
2 8   DT  n 
2 9   DG  n 
2 10  DC  n 
2 11  DA  n 
2 12  DA  n 
2 13  DG  n 
2 14  DA  n 
2 15  DA  n 
2 16  DG  n 
2 17  DT  n 
2 18  DC  n 
2 19  DC  n 
2 20  DA  n 
2 21  DG  n 
2 22  DC  n 
2 23  DA  n 
2 24  DC  n 
2 25  DG  n 
2 26  DT  n 
2 27  DA  n 
2 28  DG  n 
2 29  DG  n 
2 30  DG  n 
2 31  DG  n 
2 32  DA  n 
2 33  DG  n 
2 34  DA  n 
2 35  DA  n 
2 36  DT  n 
2 37  DT  n 
2 38  DG  n 
2 39  DG  n 
2 40  DC  n 
2 41  DC  n 
2 42  DA  n 
3 1   U   n 
3 2   C   n 
3 3   A   n 
3 4   A   n 
3 5   C   n 
3 6   G   n 
3 7   C   n 
3 8   U   n 
3 9   U   n 
3 10  G   n 
3 11  C   n 
3 12  U   n 
3 13  C   n 
3 14  G   n 
3 15  G   n 
3 16  U   n 
3 17  U   n 
3 18  C   n 
3 19  G   n 
3 20  C   n 
3 21  C   n 
3 22  G   n 
3 23  A   n 
3 24  G   n 
3 25  A   n 
3 26  C   n 
3 27  U   n 
3 28  C   n 
3 29  C   n 
3 30  C   n 
3 31  C   n 
3 32  U   n 
3 33  A   n 
3 34  C   n 
3 35  G   n 
3 36  U   n 
3 37  G   n 
3 38  C   n 
3 39  U   n 
3 40  G   n 
3 41  C   n 
3 42  U   n 
3 43  G   n 
3 44  A   n 
3 45  A   n 
3 46  G   n 
4 1   DT  n 
4 2   DG  n 
4 3   DG  n 
4 4   DC  n 
4 5   DC  n 
4 6   DA  n 
4 7   DA  n 
4 8   DT  n 
4 9   DT  n 
4 10  DC  n 
4 11  DT  n 
4 12  DC  n 
4 13  DC  n 
4 14  DC  n 
4 15  DC  n 
4 16  DT  n 
4 17  DA  n 
4 18  DC  n 
4 19  DG  n 
4 20  DT  n 
4 21  DG  n 
4 22  DC  n 
4 23  DT  n 
4 24  DG  n 
4 25  DG  n 
4 26  DA  n 
4 27  DC  n 
4 28  DT  n 
4 29  DT  n 
4 30  DC  n 
4 31  DT  n 
4 32  DT  n 
4 33  DG  n 
4 34  DC  n 
4 35  DA  n 
4 36  DA  n 
4 37  DG  n 
4 38  DG  n 
4 39  DG  n 
4 40  DC  n 
4 41  DA  n 
4 42  DG  n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 737 ? ? ? ? ? ? ? ? ? 'unclassified sequences' 12908 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 42  ? ? ? ? ? ? ? ? ? 'unclassified sequences' 12908 ? ? ? ? ? ? ? ? 'unclassified sequences' 
12908  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 46  ? ? ? ? ? ? ? ? ? 'unclassified sequences' 12908 ? ? ? ? ? ? ? ? 'unclassified sequences' 
12908  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
4 1 sample 'Biological sequence' 1 42  ? ? ? ? ? ? ? ? ? 'unclassified sequences' 12908 ? ? ? ? ? ? ? ? 'unclassified sequences' 
12908  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A   'RNA linking'       y "ADENOSINE-5'-MONOPHOSPHATE"         ? 'C10 H14 N5 O7 P' 347.221 
ALA 'L-peptide linking' y ALANINE                              ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                             ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                           ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                      ? 'C4 H7 N O4'      133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE"          ? 'C9 H14 N3 O8 P'  323.197 
CYS 'L-peptide linking' y CYSTEINE                             ? 'C3 H7 N O2 S'    121.158 
DA  'DNA linking'       y "2'-DEOXYADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O6 P' 331.222 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE"  ? 'C9 H14 N3 O7 P'  307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P' 347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE"         ? 'C10 H15 N2 O8 P' 322.208 
G   'RNA linking'       y "GUANOSINE-5'-MONOPHOSPHATE"         ? 'C10 H14 N5 O8 P' 363.221 
GLN 'L-peptide linking' y GLUTAMINE                            ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                      ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                              ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                            ? 'C6 H10 N3 O2 1'  156.162 
ILE 'L-peptide linking' y ISOLEUCINE                           ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                              ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                               ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                           ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                        ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                              ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                               ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                            ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                           ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                             ? 'C9 H11 N O3'     181.189 
U   'RNA linking'       y "URIDINE-5'-MONOPHOSPHATE"           ? 'C9 H13 N2 O9 P'  324.181 
VAL 'L-peptide linking' y VALINE                               ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   THR 2   2   ?   ?   ?   A . n 
A 1 3   PRO 3   3   ?   ?   ?   A . n 
A 1 4   LYS 4   4   ?   ?   ?   A . n 
A 1 5   THR 5   5   ?   ?   ?   A . n 
A 1 6   GLU 6   6   ?   ?   ?   A . n 
A 1 7   THR 7   7   ?   ?   ?   A . n 
A 1 8   PRO 8   8   ?   ?   ?   A . n 
A 1 9   VAL 9   9   ?   ?   ?   A . n 
A 1 10  GLY 10  10  ?   ?   ?   A . n 
A 1 11  ALA 11  11  ?   ?   ?   A . n 
A 1 12  LEU 12  12  ?   ?   ?   A . n 
A 1 13  ILE 13  13  ?   ?   ?   A . n 
A 1 14  LYS 14  14  ?   ?   ?   A . n 
A 1 15  LYS 15  15  ?   ?   ?   A . n 
A 1 16  PHE 16  16  ?   ?   ?   A . n 
A 1 17  PHE 17  17  ?   ?   ?   A . n 
A 1 18  PRO 18  18  ?   ?   ?   A . n 
A 1 19  GLY 19  19  ?   ?   ?   A . n 
A 1 20  LYS 20  20  ?   ?   ?   A . n 
A 1 21  ARG 21  21  ?   ?   ?   A . n 
A 1 22  PHE 22  22  ?   ?   ?   A . n 
A 1 23  GLN 23  23  ?   ?   ?   A . n 
A 1 24  LYS 24  24  ?   ?   ?   A . n 
A 1 25  ASN 25  25  ?   ?   ?   A . n 
A 1 26  TYR 26  26  ?   ?   ?   A . n 
A 1 27  LEU 27  27  ?   ?   ?   A . n 
A 1 28  LYS 28  28  ?   ?   ?   A . n 
A 1 29  ASP 29  29  ?   ?   ?   A . n 
A 1 30  ALA 30  30  ?   ?   ?   A . n 
A 1 31  GLY 31  31  ?   ?   ?   A . n 
A 1 32  LYS 32  32  ?   ?   ?   A . n 
A 1 33  LYS 33  33  ?   ?   ?   A . n 
A 1 34  LEU 34  34  ?   ?   ?   A . n 
A 1 35  LYS 35  35  ?   ?   ?   A . n 
A 1 36  ARG 36  36  ?   ?   ?   A . n 
A 1 37  GLU 37  37  ?   ?   ?   A . n 
A 1 38  GLY 38  38  ?   ?   ?   A . n 
A 1 39  GLU 39  39  ?   ?   ?   A . n 
A 1 40  ALA 40  40  ?   ?   ?   A . n 
A 1 41  ALA 41  41  ?   ?   ?   A . n 
A 1 42  ALA 42  42  ?   ?   ?   A . n 
A 1 43  VAL 43  43  ?   ?   ?   A . n 
A 1 44  GLU 44  44  ?   ?   ?   A . n 
A 1 45  TYR 45  45  ?   ?   ?   A . n 
A 1 46  LEU 46  46  ?   ?   ?   A . n 
A 1 47  SER 47  47  ?   ?   ?   A . n 
A 1 48  GLY 48  48  ?   ?   ?   A . n 
A 1 49  LYS 49  49  ?   ?   ?   A . n 
A 1 50  GLN 50  50  ?   ?   ?   A . n 
A 1 51  GLU 51  51  ?   ?   ?   A . n 
A 1 52  ASP 52  52  ?   ?   ?   A . n 
A 1 53  HIS 53  53  ?   ?   ?   A . n 
A 1 54  PRO 54  54  ?   ?   ?   A . n 
A 1 55  ALA 55  55  ?   ?   ?   A . n 
A 1 56  ASN 56  56  ?   ?   ?   A . n 
A 1 57  PHE 57  57  ?   ?   ?   A . n 
A 1 58  CYS 58  58  58  CYS CYS A . n 
A 1 59  PRO 59  59  59  PRO PRO A . n 
A 1 60  PRO 60  60  60  PRO PRO A . n 
A 1 61  ALA 61  61  61  ALA ALA A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  VAL 63  63  63  VAL VAL A . n 
A 1 64  ASN 64  64  64  ASN ASN A . n 
A 1 65  ILE 65  65  65  ILE ILE A . n 
A 1 66  LEU 66  66  66  LEU LEU A . n 
A 1 67  ALA 67  67  67  ALA ALA A . n 
A 1 68  GLN 68  68  68  GLN GLN A . n 
A 1 69  SER 69  69  69  SER SER A . n 
A 1 70  ARG 70  70  70  ARG ARG A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  TRP 75  75  75  TRP TRP A . n 
A 1 76  PRO 76  76  76  PRO PRO A . n 
A 1 77  ILE 77  77  77  ILE ILE A . n 
A 1 78  ASN 78  78  78  ASN ASN A . n 
A 1 79  LEU 79  79  79  LEU LEU A . n 
A 1 80  VAL 80  80  80  VAL VAL A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  LYS 82  82  82  LYS LYS A . n 
A 1 83  GLY 83  83  83  GLY GLY A . n 
A 1 84  VAL 84  84  84  VAL VAL A . n 
A 1 85  GLN 85  85  85  GLN GLN A . n 
A 1 86  GLU 86  86  86  GLU GLU A . n 
A 1 87  TYR 87  87  87  TYR TYR A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  TYR 89  89  89  TYR TYR A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  LEU 91  91  91  LEU LEU A . n 
A 1 92  THR 92  92  92  THR THR A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  ARG 96  96  96  ARG ARG A . n 
A 1 97  GLU 97  97  97  GLU GLU A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  ASN 99  99  99  ASN ASN A . n 
A 1 100 GLY 100 100 100 GLY GLY A . n 
A 1 101 ASP 101 101 101 ASP ASP A . n 
A 1 102 PHE 102 102 102 PHE PHE A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 THR 104 104 104 THR THR A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 ARG 106 106 106 ARG ARG A . n 
A 1 107 LYS 107 107 107 LYS LYS A . n 
A 1 108 SER 108 108 108 SER SER A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 ARG 111 111 111 ARG ARG A . n 
A 1 112 TRP 112 112 112 TRP TRP A . n 
A 1 113 PHE 113 113 113 PHE PHE A . n 
A 1 114 ALA 114 114 114 ALA ALA A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 THR 116 116 116 THR THR A . n 
A 1 117 GLY 117 117 117 GLY GLY A . n 
A 1 118 VAL 118 118 118 VAL VAL A . n 
A 1 119 PRO 119 119 119 PRO PRO A . n 
A 1 120 THR 120 120 120 THR THR A . n 
A 1 121 HIS 121 121 121 HIS HIS A . n 
A 1 122 GLY 122 122 122 GLY GLY A . n 
A 1 123 TYR 123 123 123 TYR TYR A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 THR 125 125 125 THR THR A . n 
A 1 126 VAL 126 126 126 VAL VAL A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 GLY 128 128 128 GLY GLY A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
A 1 130 ASN 130 130 130 ASN ASN A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 ILE 132 132 132 ILE ILE A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 ARG 134 134 134 ARG ARG A . n 
A 1 135 HIS 135 135 135 HIS HIS A . n 
A 1 136 THR 136 136 136 THR THR A . n 
A 1 137 PHE 137 137 137 PHE PHE A . n 
A 1 138 ASN 138 138 138 ASN ASN A . n 
A 1 139 ARG 139 139 139 ARG ARG A . n 
A 1 140 TYR 140 140 140 TYR TYR A . n 
A 1 141 ASP 141 141 141 ASP ASP A . n 
A 1 142 GLY 142 142 142 GLY GLY A . n 
A 1 143 VAL 143 143 143 VAL VAL A . n 
A 1 144 ILE 144 144 144 ILE ILE A . n 
A 1 145 LYS 145 145 145 LYS LYS A . n 
A 1 146 LYS 146 146 146 LYS LYS A . n 
A 1 147 VAL 147 147 147 VAL VAL A . n 
A 1 148 GLU 148 148 148 GLU GLU A . n 
A 1 149 THR 149 149 149 THR THR A . n 
A 1 150 ARG 150 150 150 ARG ARG A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 GLU 152 152 152 GLU GLU A . n 
A 1 153 LYS 153 153 153 LYS LYS A . n 
A 1 154 ARG 154 154 154 ARG ARG A . n 
A 1 155 ARG 155 155 155 ARG ARG A . n 
A 1 156 SER 156 156 156 SER SER A . n 
A 1 157 LYS 157 157 157 LYS LYS A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 THR 159 159 159 THR THR A . n 
A 1 160 ARG 160 160 160 ARG ARG A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 ASN 162 162 162 ASN ASN A . n 
A 1 163 VAL 163 163 163 VAL VAL A . n 
A 1 164 SER 164 164 164 SER SER A . n 
A 1 165 ARG 165 165 165 ARG ARG A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 ALA 167 167 167 ALA ALA A . n 
A 1 168 ASP 168 168 168 ASP ASP A . n 
A 1 169 GLY 169 169 169 GLY GLY A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 PRO 171 171 171 PRO PRO A . n 
A 1 172 PRO 172 172 172 PRO PRO A . n 
A 1 173 ILE 173 173 173 ILE ILE A . n 
A 1 174 GLU 174 174 174 GLU GLU A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 GLU 176 176 176 GLU GLU A . n 
A 1 177 PRO 177 177 177 PRO PRO A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLU 179 179 179 GLU ALA A . n 
A 1 180 THR 180 180 180 THR THR A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 PHE 182 182 182 PHE PHE A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 ASP 185 185 185 ASP ASP A . n 
A 1 186 GLY 186 186 186 GLY GLY A . n 
A 1 187 LYS 187 187 187 LYS LYS A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 LYS 189 189 189 LYS LYS A . n 
A 1 190 GLU 190 190 190 GLU GLU A . n 
A 1 191 ARG 191 191 191 ARG ARG A . n 
A 1 192 PRO 192 192 192 PRO PRO A . n 
A 1 193 GLY 193 193 193 GLY GLY A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 ASN 195 195 195 ASN ASN A . n 
A 1 196 PRO 196 196 196 PRO PRO A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 ILE 198 198 198 ILE ILE A . n 
A 1 199 TYR 199 199 199 TYR TYR A . n 
A 1 200 CYS 200 200 200 CYS CYS A . n 
A 1 201 TYR 201 201 201 TYR TYR A . n 
A 1 202 GLN 202 202 202 GLN GLN A . n 
A 1 203 GLN 203 203 203 GLN GLN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 SER 205 205 205 SER SER A . n 
A 1 206 PRO 206 206 206 PRO PRO A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 PRO 208 208 208 PRO PRO A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ASN 210 210 210 ASN ASN A . n 
A 1 211 PRO 211 211 211 PRO PRO A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 LYS 213 213 213 LYS LYS A . n 
A 1 214 HIS 214 214 214 HIS HIS A . n 
A 1 215 PRO 215 215 215 PRO PRO A . n 
A 1 216 ALA 216 216 216 ALA ALA A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 PRO 218 218 218 PRO PRO A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 SER 220 220 220 SER SER A . n 
A 1 221 GLY 221 221 221 GLY GLY A . n 
A 1 222 VAL 222 222 222 VAL VAL A . n 
A 1 223 ASP 223 223 223 ASP ASP A . n 
A 1 224 PRO 224 224 224 PRO PRO A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 ALA 226 226 226 ALA ALA A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 LEU 228 228 228 LEU LEU A . n 
A 1 229 PRO 229 229 229 PRO PRO A . n 
A 1 230 LEU 230 230 230 LEU LEU A . n 
A 1 231 GLY 231 231 231 GLY GLY A . n 
A 1 232 THR 232 232 232 THR THR A . n 
A 1 233 PRO 233 233 233 PRO PRO A . n 
A 1 234 ASN 234 234 234 ASN ASN A . n 
A 1 235 ARG 235 235 235 ARG ARG A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 SER 237 237 237 SER SER A . n 
A 1 238 ILE 238 238 238 ILE ILE A . n 
A 1 239 PRO 239 239 239 PRO PRO A . n 
A 1 240 LYS 240 240 240 LYS LYS A . n 
A 1 241 GLY 241 241 241 GLY GLY A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 PRO 243 243 243 PRO PRO A . n 
A 1 244 GLY 244 244 244 GLY GLY A . n 
A 1 245 TYR 245 245 245 TYR TYR A . n 
A 1 246 VAL 246 246 246 VAL VAL A . n 
A 1 247 PRO 247 247 247 PRO PRO A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 TRP 249 249 249 TRP TRP A . n 
A 1 250 GLN 250 250 250 GLN GLN A . n 
A 1 251 ARG 251 251 251 ARG ARG A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 HIS 253 253 253 HIS HIS A . n 
A 1 254 LEU 254 254 254 LEU LEU A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 THR 256 256 256 THR THR A . n 
A 1 257 LYS 257 257 257 LYS LYS A . n 
A 1 258 ASN 258 258 258 ASN ASN A . n 
A 1 259 LYS 259 259 259 LYS LYS A . n 
A 1 260 ARG 260 260 260 ARG ARG A . n 
A 1 261 ILE 261 261 261 ILE ILE A . n 
A 1 262 ARG 262 262 262 ARG ARG A . n 
A 1 263 LYS 263 263 263 LYS LYS A . n 
A 1 264 TRP 264 264 264 TRP TRP A . n 
A 1 265 TYR 265 265 265 TYR TYR A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 ARG 267 267 267 ARG ARG A . n 
A 1 268 ALA 268 268 268 ALA ALA A . n 
A 1 269 ASN 269 269 269 ASN ASN A . n 
A 1 270 TRP 270 270 270 TRP TRP A . n 
A 1 271 ARG 271 271 271 ARG ARG A . n 
A 1 272 ARG 272 272 272 ARG ARG A . n 
A 1 273 LYS 273 273 273 LYS LYS A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 ARG 276 276 276 ARG ARG A . n 
A 1 277 LYS 277 277 277 LYS LYS A . n 
A 1 278 SER 278 278 278 SER SER A . n 
A 1 279 VAL 279 279 279 VAL VAL A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 ASP 281 281 281 ASP ASP A . n 
A 1 282 GLU 282 282 282 GLU GLU A . n 
A 1 283 ALA 283 283 283 ALA ALA A . n 
A 1 284 LYS 284 284 284 LYS LYS A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 LYS 286 286 286 LYS LYS A . n 
A 1 287 GLU 287 287 287 GLU GLU A . n 
A 1 288 ALA 288 288 288 ALA ALA A . n 
A 1 289 ALA 289 289 289 ALA ALA A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 GLU 292 292 292 GLU GLU A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 ILE 294 294 294 ILE ILE A . n 
A 1 295 PRO 295 295 295 PRO PRO A . n 
A 1 296 ILE 296 296 296 ILE ILE A . n 
A 1 297 ILE 297 297 297 ILE ILE A . n 
A 1 298 VAL 298 298 298 VAL VAL A . n 
A 1 299 THR 299 299 299 THR THR A . n 
A 1 300 ILE 300 300 300 ILE ILE A . n 
A 1 301 GLY 301 301 301 GLY GLY A . n 
A 1 302 LYS 302 302 302 LYS LYS A . n 
A 1 303 ASP 303 303 303 ASP ASP A . n 
A 1 304 TRP 304 304 304 TRP TRP A . n 
A 1 305 ILE 305 305 305 ILE ILE A . n 
A 1 306 VAL 306 306 306 VAL VAL A . n 
A 1 307 MET 307 307 307 MET MET A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 ALA 309 309 309 ALA ALA A . n 
A 1 310 ARG 310 310 310 ARG ARG A . n 
A 1 311 GLY 311 311 311 GLY GLY A . n 
A 1 312 LEU 312 312 312 LEU LEU A . n 
A 1 313 LEU 313 313 313 LEU LEU A . n 
A 1 314 ARG 314 314 314 ARG ARG A . n 
A 1 315 ALA 315 315 315 ALA ALA A . n 
A 1 316 VAL 316 316 316 VAL VAL A . n 
A 1 317 TYR 317 317 317 TYR TYR A . n 
A 1 318 TRP 318 318 318 TRP TRP A . n 
A 1 319 ARG 319 319 319 ARG ARG A . n 
A 1 320 GLY 320 320 320 GLY GLY A . n 
A 1 321 ILE 321 321 321 ILE ILE A . n 
A 1 322 ALA 322 322 322 ALA ALA A . n 
A 1 323 LYS 323 323 323 LYS LYS A . n 
A 1 324 PRO 324 324 324 PRO GLY A . n 
A 1 325 GLY 325 325 325 GLY ALA A . n 
A 1 326 LEU 326 326 326 LEU LEU A . n 
A 1 327 SER 327 327 327 SER SER A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 LYS 329 329 329 LYS LYS A . n 
A 1 330 GLU 330 330 330 GLU GLU A . n 
A 1 331 LEU 331 331 331 LEU LEU A . n 
A 1 332 LEU 332 332 332 LEU LEU A . n 
A 1 333 GLY 333 333 333 GLY GLY A . n 
A 1 334 PHE 334 334 334 PHE PHE A . n 
A 1 335 PHE 335 335 335 PHE PHE A . n 
A 1 336 SER 336 336 336 SER SER A . n 
A 1 337 GLY 337 337 337 GLY GLY A . n 
A 1 338 ASP 338 338 338 ASP ASP A . n 
A 1 339 PRO 339 339 339 PRO PRO A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 LEU 341 341 341 LEU LEU A . n 
A 1 342 ASP 342 342 342 ASP ASP A . n 
A 1 343 PRO 343 343 343 PRO PRO A . n 
A 1 344 LYS 344 344 344 LYS LYS A . n 
A 1 345 ARG 345 345 345 ARG ARG A . n 
A 1 346 GLY 346 346 346 GLY GLY A . n 
A 1 347 ILE 347 347 347 ILE ILE A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 THR 349 349 349 THR THR A . n 
A 1 350 PHE 350 350 350 PHE PHE A . n 
A 1 351 THR 351 351 351 THR THR A . n 
A 1 352 PHE 352 352 352 PHE PHE A . n 
A 1 353 LYS 353 353 353 LYS LYS A . n 
A 1 354 LEU 354 354 354 LEU LEU A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 ALA 356 356 ?   ?   ?   A . n 
A 1 357 VAL 357 357 ?   ?   ?   A . n 
A 1 358 ALA 358 358 ?   ?   ?   A . n 
A 1 359 VAL 359 359 ?   ?   ?   A . n 
A 1 360 HIS 360 360 ?   ?   ?   A . n 
A 1 361 SER 361 361 ?   ?   ?   A . n 
A 1 362 ARG 362 362 ?   ?   ?   A . n 
A 1 363 LYS 363 363 ?   ?   ?   A . n 
A 1 364 PRO 364 364 ?   ?   ?   A . n 
A 1 365 THR 365 365 ?   ?   ?   A . n 
A 1 366 ARG 366 366 ?   ?   ?   A . n 
A 1 367 GLY 367 367 ?   ?   ?   A . n 
A 1 368 LYS 368 368 ?   ?   ?   A . n 
A 1 369 LYS 369 369 ?   ?   ?   A . n 
A 1 370 SER 370 370 ?   ?   ?   A . n 
A 1 371 LYS 371 371 ?   ?   ?   A . n 
A 1 372 GLU 372 372 ?   ?   ?   A . n 
A 1 373 LEU 373 373 ?   ?   ?   A . n 
A 1 374 LEU 374 374 ?   ?   ?   A . n 
A 1 375 LEU 375 375 ?   ?   ?   A . n 
A 1 376 SER 376 376 ?   ?   ?   A . n 
A 1 377 MET 377 377 ?   ?   ?   A . n 
A 1 378 THR 378 378 ?   ?   ?   A . n 
A 1 379 ALA 379 379 ?   ?   ?   A . n 
A 1 380 GLU 380 380 ?   ?   ?   A . n 
A 1 381 LYS 381 381 ?   ?   ?   A . n 
A 1 382 PRO 382 382 ?   ?   ?   A . n 
A 1 383 HIS 383 383 ?   ?   ?   A . n 
A 1 384 VAL 384 384 ?   ?   ?   A . n 
A 1 385 GLY 385 385 ?   ?   ?   A . n 
A 1 386 LEU 386 386 ?   ?   ?   A . n 
A 1 387 VAL 387 387 ?   ?   ?   A . n 
A 1 388 ALA 388 388 ?   ?   ?   A . n 
A 1 389 ILE 389 389 ?   ?   ?   A . n 
A 1 390 ASP 390 390 ?   ?   ?   A . n 
A 1 391 LEU 391 391 ?   ?   ?   A . n 
A 1 392 GLY 392 392 ?   ?   ?   A . n 
A 1 393 GLN 393 393 ?   ?   ?   A . n 
A 1 394 THR 394 394 ?   ?   ?   A . n 
A 1 395 ASN 395 395 ?   ?   ?   A . n 
A 1 396 PRO 396 396 ?   ?   ?   A . n 
A 1 397 VAL 397 397 ?   ?   ?   A . n 
A 1 398 ALA 398 398 ?   ?   ?   A . n 
A 1 399 ALA 399 399 ?   ?   ?   A . n 
A 1 400 GLU 400 400 ?   ?   ?   A . n 
A 1 401 PHE 401 401 ?   ?   ?   A . n 
A 1 402 SER 402 402 ?   ?   ?   A . n 
A 1 403 ARG 403 403 ?   ?   ?   A . n 
A 1 404 VAL 404 404 ?   ?   ?   A . n 
A 1 405 LYS 405 405 ?   ?   ?   A . n 
A 1 406 ARG 406 406 ?   ?   ?   A . n 
A 1 407 GLU 407 407 ?   ?   ?   A . n 
A 1 408 GLY 408 408 ?   ?   ?   A . n 
A 1 409 GLU 409 409 ?   ?   ?   A . n 
A 1 410 THR 410 410 ?   ?   ?   A . n 
A 1 411 LEU 411 411 ?   ?   ?   A . n 
A 1 412 GLN 412 412 ?   ?   ?   A . n 
A 1 413 ALA 413 413 ?   ?   ?   A . n 
A 1 414 GLU 414 414 ?   ?   ?   A . n 
A 1 415 PRO 415 415 ?   ?   ?   A . n 
A 1 416 LEU 416 416 ?   ?   ?   A . n 
A 1 417 GLY 417 417 ?   ?   ?   A . n 
A 1 418 GLN 418 418 ?   ?   ?   A . n 
A 1 419 ILE 419 419 ?   ?   ?   A . n 
A 1 420 VAL 420 420 ?   ?   ?   A . n 
A 1 421 LEU 421 421 ?   ?   ?   A . n 
A 1 422 PRO 422 422 ?   ?   ?   A . n 
A 1 423 ASP 423 423 ?   ?   ?   A . n 
A 1 424 ASP 424 424 ?   ?   ?   A . n 
A 1 425 LEU 425 425 ?   ?   ?   A . n 
A 1 426 VAL 426 426 ?   ?   ?   A . n 
A 1 427 LYS 427 427 ?   ?   ?   A . n 
A 1 428 ASP 428 428 ?   ?   ?   A . n 
A 1 429 LEU 429 429 ?   ?   ?   A . n 
A 1 430 THR 430 430 ?   ?   ?   A . n 
A 1 431 ARG 431 431 ?   ?   ?   A . n 
A 1 432 TYR 432 432 ?   ?   ?   A . n 
A 1 433 ARG 433 433 ?   ?   ?   A . n 
A 1 434 ARG 434 434 ?   ?   ?   A . n 
A 1 435 ALA 435 435 ?   ?   ?   A . n 
A 1 436 TRP 436 436 ?   ?   ?   A . n 
A 1 437 ASP 437 437 ?   ?   ?   A . n 
A 1 438 ALA 438 438 ?   ?   ?   A . n 
A 1 439 THR 439 439 ?   ?   ?   A . n 
A 1 440 GLU 440 440 ?   ?   ?   A . n 
A 1 441 GLU 441 441 ?   ?   ?   A . n 
A 1 442 GLN 442 442 ?   ?   ?   A . n 
A 1 443 ILE 443 443 ?   ?   ?   A . n 
A 1 444 LYS 444 444 ?   ?   ?   A . n 
A 1 445 ALA 445 445 ?   ?   ?   A . n 
A 1 446 GLU 446 446 ?   ?   ?   A . n 
A 1 447 ALA 447 447 ?   ?   ?   A . n 
A 1 448 ILE 448 448 ?   ?   ?   A . n 
A 1 449 VAL 449 449 ?   ?   ?   A . n 
A 1 450 GLN 450 450 ?   ?   ?   A . n 
A 1 451 LEU 451 451 ?   ?   ?   A . n 
A 1 452 PRO 452 452 ?   ?   ?   A . n 
A 1 453 GLU 453 453 ?   ?   ?   A . n 
A 1 454 GLU 454 454 ?   ?   ?   A . n 
A 1 455 CYS 455 455 ?   ?   ?   A . n 
A 1 456 ARG 456 456 ?   ?   ?   A . n 
A 1 457 ALA 457 457 ?   ?   ?   A . n 
A 1 458 GLU 458 458 ?   ?   ?   A . n 
A 1 459 VAL 459 459 ?   ?   ?   A . n 
A 1 460 VAL 460 460 ?   ?   ?   A . n 
A 1 461 LYS 461 461 ?   ?   ?   A . n 
A 1 462 VAL 462 462 ?   ?   ?   A . n 
A 1 463 ASN 463 463 ?   ?   ?   A . n 
A 1 464 GLN 464 464 ?   ?   ?   A . n 
A 1 465 MET 465 465 ?   ?   ?   A . n 
A 1 466 SER 466 466 ?   ?   ?   A . n 
A 1 467 ALA 467 467 ?   ?   ?   A . n 
A 1 468 GLU 468 468 ?   ?   ?   A . n 
A 1 469 GLU 469 469 ?   ?   ?   A . n 
A 1 470 THR 470 470 ?   ?   ?   A . n 
A 1 471 LYS 471 471 ?   ?   ?   A . n 
A 1 472 HIS 472 472 ?   ?   ?   A . n 
A 1 473 LEU 473 473 ?   ?   ?   A . n 
A 1 474 ILE 474 474 ?   ?   ?   A . n 
A 1 475 LEU 475 475 ?   ?   ?   A . n 
A 1 476 ASP 476 476 ?   ?   ?   A . n 
A 1 477 ARG 477 477 ?   ?   ?   A . n 
A 1 478 GLY 478 478 ?   ?   ?   A . n 
A 1 479 VAL 479 479 ?   ?   ?   A . n 
A 1 480 SER 480 480 ?   ?   ?   A . n 
A 1 481 GLY 481 481 ?   ?   ?   A . n 
A 1 482 ASP 482 482 ?   ?   ?   A . n 
A 1 483 LEU 483 483 ?   ?   ?   A . n 
A 1 484 PRO 484 484 ?   ?   ?   A . n 
A 1 485 TRP 485 485 ?   ?   ?   A . n 
A 1 486 GLU 486 486 ?   ?   ?   A . n 
A 1 487 LYS 487 487 ?   ?   ?   A . n 
A 1 488 MET 488 488 ?   ?   ?   A . n 
A 1 489 THR 489 489 ?   ?   ?   A . n 
A 1 490 SER 490 490 ?   ?   ?   A . n 
A 1 491 ASN 491 491 ?   ?   ?   A . n 
A 1 492 THR 492 492 ?   ?   ?   A . n 
A 1 493 THR 493 493 ?   ?   ?   A . n 
A 1 494 PHE 494 494 ?   ?   ?   A . n 
A 1 495 ILE 495 495 ?   ?   ?   A . n 
A 1 496 SER 496 496 ?   ?   ?   A . n 
A 1 497 ASP 497 497 ?   ?   ?   A . n 
A 1 498 HIS 498 498 ?   ?   ?   A . n 
A 1 499 LEU 499 499 ?   ?   ?   A . n 
A 1 500 LEU 500 500 ?   ?   ?   A . n 
A 1 501 ALA 501 501 ?   ?   ?   A . n 
A 1 502 LYS 502 502 ?   ?   ?   A . n 
A 1 503 GLY 503 503 ?   ?   ?   A . n 
A 1 504 VAL 504 504 ?   ?   ?   A . n 
A 1 505 THR 505 505 ?   ?   ?   A . n 
A 1 506 ASP 506 506 ?   ?   ?   A . n 
A 1 507 GLN 507 507 ?   ?   ?   A . n 
A 1 508 VAL 508 508 ?   ?   ?   A . n 
A 1 509 PHE 509 509 ?   ?   ?   A . n 
A 1 510 PHE 510 510 ?   ?   ?   A . n 
A 1 511 GLU 511 511 ?   ?   ?   A . n 
A 1 512 LYS 512 512 ?   ?   ?   A . n 
A 1 513 LYS 513 513 ?   ?   ?   A . n 
A 1 514 SER 514 514 ?   ?   ?   A . n 
A 1 515 LYS 515 515 ?   ?   ?   A . n 
A 1 516 GLY 516 516 ?   ?   ?   A . n 
A 1 517 LYS 517 517 ?   ?   ?   A . n 
A 1 518 LYS 518 518 ?   ?   ?   A . n 
A 1 519 LYS 519 519 ?   ?   ?   A . n 
A 1 520 GLY 520 520 ?   ?   ?   A . n 
A 1 521 THR 521 521 ?   ?   ?   A . n 
A 1 522 GLU 522 522 ?   ?   ?   A . n 
A 1 523 THR 523 523 ?   ?   ?   A . n 
A 1 524 VAL 524 524 ?   ?   ?   A . n 
A 1 525 LYS 525 525 ?   ?   ?   A . n 
A 1 526 ARG 526 526 ?   ?   ?   A . n 
A 1 527 LYS 527 527 ?   ?   ?   A . n 
A 1 528 ASP 528 528 ?   ?   ?   A . n 
A 1 529 TYR 529 529 ?   ?   ?   A . n 
A 1 530 GLY 530 530 ?   ?   ?   A . n 
A 1 531 TRP 531 531 ?   ?   ?   A . n 
A 1 532 VAL 532 532 ?   ?   ?   A . n 
A 1 533 LYS 533 533 ?   ?   ?   A . n 
A 1 534 LEU 534 534 ?   ?   ?   A . n 
A 1 535 LEU 535 535 ?   ?   ?   A . n 
A 1 536 ARG 536 536 ?   ?   ?   A . n 
A 1 537 PRO 537 537 ?   ?   ?   A . n 
A 1 538 ARG 538 538 ?   ?   ?   A . n 
A 1 539 LEU 539 539 ?   ?   ?   A . n 
A 1 540 SER 540 540 ?   ?   ?   A . n 
A 1 541 GLN 541 541 ?   ?   ?   A . n 
A 1 542 GLU 542 542 ?   ?   ?   A . n 
A 1 543 THR 543 543 ?   ?   ?   A . n 
A 1 544 ARG 544 544 ?   ?   ?   A . n 
A 1 545 LYS 545 545 ?   ?   ?   A . n 
A 1 546 ALA 546 546 ?   ?   ?   A . n 
A 1 547 VAL 547 547 ?   ?   ?   A . n 
A 1 548 ASN 548 548 ?   ?   ?   A . n 
A 1 549 ASP 549 549 ?   ?   ?   A . n 
A 1 550 LYS 550 550 ?   ?   ?   A . n 
A 1 551 THR 551 551 ?   ?   ?   A . n 
A 1 552 TRP 552 552 ?   ?   ?   A . n 
A 1 553 GLU 553 553 ?   ?   ?   A . n 
A 1 554 LEU 554 554 ?   ?   ?   A . n 
A 1 555 LYS 555 555 ?   ?   ?   A . n 
A 1 556 ARG 556 556 ?   ?   ?   A . n 
A 1 557 ALA 557 557 ?   ?   ?   A . n 
A 1 558 SER 558 558 ?   ?   ?   A . n 
A 1 559 THR 559 559 ?   ?   ?   A . n 
A 1 560 GLU 560 560 ?   ?   ?   A . n 
A 1 561 TYR 561 561 ?   ?   ?   A . n 
A 1 562 VAL 562 562 ?   ?   ?   A . n 
A 1 563 ARG 563 563 ?   ?   ?   A . n 
A 1 564 LEU 564 564 ?   ?   ?   A . n 
A 1 565 SER 565 565 ?   ?   ?   A . n 
A 1 566 ARG 566 566 ?   ?   ?   A . n 
A 1 567 ARG 567 567 ?   ?   ?   A . n 
A 1 568 LYS 568 568 ?   ?   ?   A . n 
A 1 569 THR 569 569 ?   ?   ?   A . n 
A 1 570 GLU 570 570 ?   ?   ?   A . n 
A 1 571 LEU 571 571 ?   ?   ?   A . n 
A 1 572 ALA 572 572 ?   ?   ?   A . n 
A 1 573 ARG 573 573 ?   ?   ?   A . n 
A 1 574 ARG 574 574 ?   ?   ?   A . n 
A 1 575 CYS 575 575 ?   ?   ?   A . n 
A 1 576 VAL 576 576 ?   ?   ?   A . n 
A 1 577 ASN 577 577 ?   ?   ?   A . n 
A 1 578 TYR 578 578 ?   ?   ?   A . n 
A 1 579 ILE 579 579 ?   ?   ?   A . n 
A 1 580 VAL 580 580 ?   ?   ?   A . n 
A 1 581 ARG 581 581 ?   ?   ?   A . n 
A 1 582 GLU 582 582 ?   ?   ?   A . n 
A 1 583 THR 583 583 ?   ?   ?   A . n 
A 1 584 LYS 584 584 ?   ?   ?   A . n 
A 1 585 ARG 585 585 ?   ?   ?   A . n 
A 1 586 TRP 586 586 ?   ?   ?   A . n 
A 1 587 THR 587 587 ?   ?   ?   A . n 
A 1 588 GLN 588 588 ?   ?   ?   A . n 
A 1 589 CYS 589 589 ?   ?   ?   A . n 
A 1 590 GLU 590 590 ?   ?   ?   A . n 
A 1 591 ASP 591 591 ?   ?   ?   A . n 
A 1 592 ILE 592 592 ?   ?   ?   A . n 
A 1 593 ALA 593 593 ?   ?   ?   A . n 
A 1 594 ILE 594 594 ?   ?   ?   A . n 
A 1 595 VAL 595 595 ?   ?   ?   A . n 
A 1 596 ILE 596 596 ?   ?   ?   A . n 
A 1 597 GLU 597 597 ?   ?   ?   A . n 
A 1 598 ASP 598 598 ?   ?   ?   A . n 
A 1 599 LEU 599 599 ?   ?   ?   A . n 
A 1 600 ASN 600 600 ?   ?   ?   A . n 
A 1 601 VAL 601 601 ?   ?   ?   A . n 
A 1 602 ARG 602 602 ?   ?   ?   A . n 
A 1 603 PHE 603 603 ?   ?   ?   A . n 
A 1 604 PHE 604 604 ?   ?   ?   A . n 
A 1 605 HIS 605 605 ?   ?   ?   A . n 
A 1 606 GLY 606 606 ?   ?   ?   A . n 
A 1 607 SER 607 607 ?   ?   ?   A . n 
A 1 608 GLY 608 608 ?   ?   ?   A . n 
A 1 609 GLU 609 609 ?   ?   ?   A . n 
A 1 610 ARG 610 610 ?   ?   ?   A . n 
A 1 611 PRO 611 611 ?   ?   ?   A . n 
A 1 612 ASP 612 612 ?   ?   ?   A . n 
A 1 613 GLY 613 613 ?   ?   ?   A . n 
A 1 614 TRP 614 614 ?   ?   ?   A . n 
A 1 615 ASP 615 615 ?   ?   ?   A . n 
A 1 616 ASN 616 616 ?   ?   ?   A . n 
A 1 617 PHE 617 617 ?   ?   ?   A . n 
A 1 618 PHE 618 618 ?   ?   ?   A . n 
A 1 619 ILE 619 619 ?   ?   ?   A . n 
A 1 620 SER 620 620 ?   ?   ?   A . n 
A 1 621 LYS 621 621 ?   ?   ?   A . n 
A 1 622 ARG 622 622 ?   ?   ?   A . n 
A 1 623 GLU 623 623 ?   ?   ?   A . n 
A 1 624 ASN 624 624 ?   ?   ?   A . n 
A 1 625 ARG 625 625 ?   ?   ?   A . n 
A 1 626 TRP 626 626 ?   ?   ?   A . n 
A 1 627 PHE 627 627 ?   ?   ?   A . n 
A 1 628 ILE 628 628 ?   ?   ?   A . n 
A 1 629 GLN 629 629 ?   ?   ?   A . n 
A 1 630 VAL 630 630 ?   ?   ?   A . n 
A 1 631 LEU 631 631 ?   ?   ?   A . n 
A 1 632 HIS 632 632 ?   ?   ?   A . n 
A 1 633 LYS 633 633 ?   ?   ?   A . n 
A 1 634 ALA 634 634 ?   ?   ?   A . n 
A 1 635 PHE 635 635 ?   ?   ?   A . n 
A 1 636 SER 636 636 ?   ?   ?   A . n 
A 1 637 ASP 637 637 ?   ?   ?   A . n 
A 1 638 LEU 638 638 ?   ?   ?   A . n 
A 1 639 ALA 639 639 ?   ?   ?   A . n 
A 1 640 LEU 640 640 ?   ?   ?   A . n 
A 1 641 HIS 641 641 ?   ?   ?   A . n 
A 1 642 ARG 642 642 ?   ?   ?   A . n 
A 1 643 GLY 643 643 ?   ?   ?   A . n 
A 1 644 LEU 644 644 ?   ?   ?   A . n 
A 1 645 PRO 645 645 ?   ?   ?   A . n 
A 1 646 VAL 646 646 ?   ?   ?   A . n 
A 1 647 ILE 647 647 ?   ?   ?   A . n 
A 1 648 GLU 648 648 ?   ?   ?   A . n 
A 1 649 ALA 649 649 ?   ?   ?   A . n 
A 1 650 ASN 650 650 ?   ?   ?   A . n 
A 1 651 PRO 651 651 ?   ?   ?   A . n 
A 1 652 ALA 652 652 ?   ?   ?   A . n 
A 1 653 ARG 653 653 ?   ?   ?   A . n 
A 1 654 THR 654 654 ?   ?   ?   A . n 
A 1 655 SER 655 655 ?   ?   ?   A . n 
A 1 656 ILE 656 656 ?   ?   ?   A . n 
A 1 657 THR 657 657 ?   ?   ?   A . n 
A 1 658 CYS 658 658 ?   ?   ?   A . n 
A 1 659 ILE 659 659 ?   ?   ?   A . n 
A 1 660 ARG 660 660 ?   ?   ?   A . n 
A 1 661 CYS 661 661 ?   ?   ?   A . n 
A 1 662 GLY 662 662 ?   ?   ?   A . n 
A 1 663 HIS 663 663 ?   ?   ?   A . n 
A 1 664 CYS 664 664 ?   ?   ?   A . n 
A 1 665 ASP 665 665 ?   ?   ?   A . n 
A 1 666 ARG 666 666 ?   ?   ?   A . n 
A 1 667 ASN 667 667 ?   ?   ?   A . n 
A 1 668 ASN 668 668 ?   ?   ?   A . n 
A 1 669 ARG 669 669 ?   ?   ?   A . n 
A 1 670 HIS 670 670 ?   ?   ?   A . n 
A 1 671 GLY 671 671 ?   ?   ?   A . n 
A 1 672 GLU 672 672 ?   ?   ?   A . n 
A 1 673 MET 673 673 ?   ?   ?   A . n 
A 1 674 PHE 674 674 ?   ?   ?   A . n 
A 1 675 LEU 675 675 ?   ?   ?   A . n 
A 1 676 CYS 676 676 ?   ?   ?   A . n 
A 1 677 LEU 677 677 ?   ?   ?   A . n 
A 1 678 SER 678 678 ?   ?   ?   A . n 
A 1 679 CYS 679 679 ?   ?   ?   A . n 
A 1 680 ASN 680 680 ?   ?   ?   A . n 
A 1 681 ASP 681 681 ?   ?   ?   A . n 
A 1 682 LEU 682 682 ?   ?   ?   A . n 
A 1 683 ARG 683 683 ?   ?   ?   A . n 
A 1 684 HIS 684 684 ?   ?   ?   A . n 
A 1 685 ALA 685 685 ?   ?   ?   A . n 
A 1 686 ASP 686 686 ?   ?   ?   A . n 
A 1 687 ARG 687 687 ?   ?   ?   A . n 
A 1 688 GLU 688 688 ?   ?   ?   A . n 
A 1 689 ILE 689 689 ?   ?   ?   A . n 
A 1 690 ALA 690 690 ?   ?   ?   A . n 
A 1 691 THR 691 691 ?   ?   ?   A . n 
A 1 692 ARG 692 692 ?   ?   ?   A . n 
A 1 693 ASN 693 693 ?   ?   ?   A . n 
A 1 694 LEU 694 694 ?   ?   ?   A . n 
A 1 695 THR 695 695 ?   ?   ?   A . n 
A 1 696 ARG 696 696 ?   ?   ?   A . n 
A 1 697 VAL 697 697 ?   ?   ?   A . n 
A 1 698 ALA 698 698 ?   ?   ?   A . n 
A 1 699 VAL 699 699 ?   ?   ?   A . n 
A 1 700 THR 700 700 ?   ?   ?   A . n 
A 1 701 GLY 701 701 ?   ?   ?   A . n 
A 1 702 GLU 702 702 ?   ?   ?   A . n 
A 1 703 MET 703 703 ?   ?   ?   A . n 
A 1 704 ILE 704 704 ?   ?   ?   A . n 
A 1 705 PRO 705 705 ?   ?   ?   A . n 
A 1 706 ARG 706 706 ?   ?   ?   A . n 
A 1 707 ARG 707 707 ?   ?   ?   A . n 
A 1 708 ILE 708 708 ?   ?   ?   A . n 
A 1 709 GLU 709 709 ?   ?   ?   A . n 
A 1 710 PRO 710 710 ?   ?   ?   A . n 
A 1 711 GLY 711 711 ?   ?   ?   A . n 
A 1 712 GLU 712 712 ?   ?   ?   A . n 
A 1 713 GLN 713 713 ?   ?   ?   A . n 
A 1 714 SER 714 714 ?   ?   ?   A . n 
A 1 715 GLY 715 715 ?   ?   ?   A . n 
A 1 716 ASP 716 716 ?   ?   ?   A . n 
A 1 717 THR 717 717 ?   ?   ?   A . n 
A 1 718 LYS 718 718 ?   ?   ?   A . n 
A 1 719 LYS 719 719 ?   ?   ?   A . n 
A 1 720 ALA 720 720 ?   ?   ?   A . n 
A 1 721 ARG 721 721 ?   ?   ?   A . n 
A 1 722 SER 722 722 ?   ?   ?   A . n 
A 1 723 ALA 723 723 ?   ?   ?   A . n 
A 1 724 ARG 724 724 ?   ?   ?   A . n 
A 1 725 LYS 725 725 ?   ?   ?   A . n 
A 1 726 GLY 726 726 ?   ?   ?   A . n 
A 1 727 LYS 727 727 ?   ?   ?   A . n 
A 1 728 LYS 728 728 ?   ?   ?   A . n 
A 1 729 ALA 729 729 ?   ?   ?   A . n 
A 1 730 VAL 730 730 ?   ?   ?   A . n 
A 1 731 ILE 731 731 ?   ?   ?   A . n 
A 1 732 SER 732 732 ?   ?   ?   A . n 
A 1 733 LYS 733 733 ?   ?   ?   A . n 
A 1 734 ARG 734 734 ?   ?   ?   A . n 
A 1 735 GLU 735 735 ?   ?   ?   A . n 
A 1 736 ALA 736 736 ?   ?   ?   A . n 
A 1 737 ALA 737 737 ?   ?   ?   A . n 
B 2 1   DC  1   -32 ?   ?   ?   C . n 
B 2 2   DT  2   -31 ?   ?   ?   C . n 
B 2 3   DG  3   -30 ?   ?   ?   C . n 
B 2 4   DC  4   -29 ?   ?   ?   C . n 
B 2 5   DC  5   -28 ?   ?   ?   C . n 
B 2 6   DC  6   -27 ?   ?   ?   C . n 
B 2 7   DT  7   -26 ?   ?   ?   C . n 
B 2 8   DT  8   -25 ?   ?   ?   C . n 
B 2 9   DG  9   -24 ?   ?   ?   C . n 
B 2 10  DC  10  -23 ?   ?   ?   C . n 
B 2 11  DA  11  -22 ?   ?   ?   C . n 
B 2 12  DA  12  -21 ?   ?   ?   C . n 
B 2 13  DG  13  -20 ?   ?   ?   C . n 
B 2 14  DA  14  -19 ?   ?   ?   C . n 
B 2 15  DA  15  -18 ?   ?   ?   C . n 
B 2 16  DG  16  -17 ?   ?   ?   C . n 
B 2 17  DT  17  -16 ?   ?   ?   C . n 
B 2 18  DC  18  -15 ?   ?   ?   C . n 
B 2 19  DC  19  -14 ?   ?   ?   C . n 
B 2 20  DA  20  -13 ?   ?   ?   C . n 
B 2 21  DG  21  -12 -12 DG  DG  C . n 
B 2 22  DC  22  -11 -11 DC  DC  C . n 
B 2 23  DA  23  -10 -10 DA  DA  C . n 
B 2 24  DC  24  -9  -9  DC  DC  C . n 
B 2 25  DG  25  -8  -8  DG  DG  C . n 
B 2 26  DT  26  -7  -7  DT  DT  C . n 
B 2 27  DA  27  -6  -6  DA  DA  C . n 
B 2 28  DG  28  -5  -5  DG  DG  C . n 
B 2 29  DG  29  -4  -4  DG  DG  C . n 
B 2 30  DG  30  -3  -3  DG  DG  C . n 
B 2 31  DG  31  -2  -2  DG  DG  C . n 
B 2 32  DA  32  -1  -1  DA  DA  C . n 
B 2 33  DG  33  0   0   DG  DG  C . n 
B 2 34  DA  34  1   1   DA  DA  C . n 
B 2 35  DA  35  2   2   DA  DA  C . n 
B 2 36  DT  36  3   3   DT  DT  C . n 
B 2 37  DT  37  4   4   DT  DT  C . n 
B 2 38  DG  38  5   5   DG  DG  C . n 
B 2 39  DG  39  6   6   DG  DG  C . n 
B 2 40  DC  40  7   ?   ?   ?   C . n 
B 2 41  DC  41  8   ?   ?   ?   C . n 
B 2 42  DA  42  9   ?   ?   ?   C . n 
C 3 1   U   1   -25 ?   ?   ?   B . n 
C 3 2   C   2   -24 ?   ?   ?   B . n 
C 3 3   A   3   -23 ?   ?   ?   B . n 
C 3 4   A   4   -22 ?   ?   ?   B . n 
C 3 5   C   5   -21 ?   ?   ?   B . n 
C 3 6   G   6   -20 ?   ?   ?   B . n 
C 3 7   C   7   -19 -19 C   C   B . n 
C 3 8   U   8   -18 -18 U   U   B . n 
C 3 9   U   9   -17 -17 U   U   B . n 
C 3 10  G   10  -16 -16 G   G   B . n 
C 3 11  C   11  -15 -15 C   C   B . n 
C 3 12  U   12  -14 -14 U   U   B . n 
C 3 13  C   13  -13 -13 C   C   B . n 
C 3 14  G   14  -12 -12 G   G   B . n 
C 3 15  G   15  -11 -11 G   G   B . n 
C 3 16  U   16  -10 -10 U   U   B . n 
C 3 17  U   17  -9  -9  U   U   B . n 
C 3 18  C   18  -8  -8  C   C   B . n 
C 3 19  G   19  -7  -7  G   G   B . n 
C 3 20  C   20  -6  -6  C   C   B . n 
C 3 21  C   21  -5  -5  C   C   B . n 
C 3 22  G   22  -4  -4  G   G   B . n 
C 3 23  A   23  -3  -3  A   A   B . n 
C 3 24  G   24  -2  -2  G   G   B . n 
C 3 25  A   25  -1  -1  A   A   B . n 
C 3 26  C   26  0   0   C   C   B . n 
C 3 27  U   27  1   1   U   U   B . n 
C 3 28  C   28  2   2   C   C   B . n 
C 3 29  C   29  3   3   C   C   B . n 
C 3 30  C   30  4   4   C   C   B . n 
C 3 31  C   31  5   5   C   C   B . n 
C 3 32  U   32  6   6   U   U   B . n 
C 3 33  A   33  7   7   A   A   B . n 
C 3 34  C   34  8   8   C   C   B . n 
C 3 35  G   35  9   9   G   G   B . n 
C 3 36  U   36  10  10  U   U   B . n 
C 3 37  G   37  11  11  G   G   B . n 
C 3 38  C   38  12  ?   ?   ?   B . n 
C 3 39  U   39  13  ?   ?   ?   B . n 
C 3 40  G   40  14  ?   ?   ?   B . n 
C 3 41  C   41  15  ?   ?   ?   B . n 
C 3 42  U   42  16  ?   ?   ?   B . n 
C 3 43  G   43  17  ?   ?   ?   B . n 
C 3 44  A   44  18  ?   ?   ?   B . n 
C 3 45  A   45  19  ?   ?   ?   B . n 
C 3 46  G   46  20  ?   ?   ?   B . n 
D 4 1   DT  1   -9  ?   ?   ?   D . n 
D 4 2   DG  2   -8  ?   ?   ?   D . n 
D 4 3   DG  3   -7  ?   ?   ?   D . n 
D 4 4   DC  4   -6  -6  DC  DC  D . n 
D 4 5   DC  5   -5  -5  DC  DC  D . n 
D 4 6   DA  6   -4  -4  DA  DA  D . n 
D 4 7   DA  7   -3  -3  DA  DA  D . n 
D 4 8   DT  8   -2  -2  DT  DT  D . n 
D 4 9   DT  9   -1  -1  DT  DT  D . n 
D 4 10  DC  10  0   0   DC  DC  D . n 
D 4 11  DT  11  1   1   DT  DT  D . n 
D 4 12  DC  12  2   ?   ?   ?   D . n 
D 4 13  DC  13  3   ?   ?   ?   D . n 
D 4 14  DC  14  4   ?   ?   ?   D . n 
D 4 15  DC  15  5   ?   ?   ?   D . n 
D 4 16  DT  16  6   ?   ?   ?   D . n 
D 4 17  DA  17  7   ?   ?   ?   D . n 
D 4 18  DC  18  8   ?   ?   ?   D . n 
D 4 19  DG  19  9   ?   ?   ?   D . n 
D 4 20  DT  20  10  ?   ?   ?   D . n 
D 4 21  DG  21  11  ?   ?   ?   D . n 
D 4 22  DC  22  12  ?   ?   ?   D . n 
D 4 23  DT  23  13  ?   ?   ?   D . n 
D 4 24  DG  24  14  ?   ?   ?   D . n 
D 4 25  DG  25  15  ?   ?   ?   D . n 
D 4 26  DA  26  16  ?   ?   ?   D . n 
D 4 27  DC  27  17  ?   ?   ?   D . n 
D 4 28  DT  28  18  ?   ?   ?   D . n 
D 4 29  DT  29  19  ?   ?   ?   D . n 
D 4 30  DC  30  20  ?   ?   ?   D . n 
D 4 31  DT  31  21  ?   ?   ?   D . n 
D 4 32  DT  32  22  ?   ?   ?   D . n 
D 4 33  DG  33  23  ?   ?   ?   D . n 
D 4 34  DC  34  24  ?   ?   ?   D . n 
D 4 35  DA  35  25  ?   ?   ?   D . n 
D 4 36  DA  36  26  ?   ?   ?   D . n 
D 4 37  DG  37  27  ?   ?   ?   D . n 
D 4 38  DG  38  28  ?   ?   ?   D . n 
D 4 39  DG  39  29  ?   ?   ?   D . n 
D 4 40  DC  40  30  ?   ?   ?   D . n 
D 4 41  DA  41  31  ?   ?   ?   D . n 
D 4 42  DG  42  32  ?   ?   ?   D . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A GLU 179 ? CG  ? A GLU 179 CG  
2 1 Y 1 A GLU 179 ? CD  ? A GLU 179 CD  
3 1 Y 1 A GLU 179 ? OE1 ? A GLU 179 OE1 
4 1 Y 1 A GLU 179 ? OE2 ? A GLU 179 OE2 
5 1 Y 1 A PRO 324 ? CB  ? A PRO 324 CB  
6 1 Y 1 A PRO 324 ? CG  ? A PRO 324 CG  
7 1 Y 1 A PRO 324 ? CD  ? A PRO 324 CD  
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8WS6 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8WS6 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8WS6 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8WS6 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003  ? 3812 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.537  ? 5438 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 19.858 ? 989  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.035  ? 621  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.007  ? 486  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8WS6 
_struct.title                        'Cryo-EM mini structure of Cas12-1 with 14 nt complementary heteroduplex' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8WS6 
_struct_keywords.text            'Crispr-Cas12-1, RNA BINDING PROTEIN-RNA-DNA complex' 
_struct_keywords.pdbx_keywords   'RNA BINDING PROTEIN/RNA/DNA' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8WS6 8WS6 ? 1 ? 1 
2 PDB 8WS6 8WS6 ? 2 ? 1 
3 PDB 8WS6 8WS6 ? 3 ? 1 
4 PDB 8WS6 8WS6 ? 4 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8WS6 A 1 ? 737 ? 8WS6 1   ? 737 ? 1   737 
2 2 8WS6 C 1 ? 42  ? 8WS6 -32 ? 9   ? -32 9   
3 3 8WS6 B 1 ? 46  ? 8WS6 -25 ? 20  ? -25 20  
4 4 8WS6 D 1 ? 42  ? 8WS6 -9  ? 32  ? -9  32  
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 TRP A 75  ? TYR A 89  ? TRP A 75  TYR A 89  1 ? 15 
HELX_P HELX_P2  AA2 ALA A 94  ? GLY A 100 ? ALA A 94  GLY A 100 1 ? 7  
HELX_P HELX_P3  AA3 SER A 105 ? THR A 116 ? SER A 105 THR A 116 1 ? 12 
HELX_P HELX_P4  AA4 THR A 125 ? LEU A 129 ? THR A 125 LEU A 129 5 ? 5  
HELX_P HELX_P5  AA5 ILE A 132 ? THR A 149 ? ILE A 132 THR A 149 1 ? 18 
HELX_P HELX_P6  AA6 ARG A 150 ? GLY A 169 ? ARG A 150 GLY A 169 1 ? 20 
HELX_P HELX_P7  AA7 ALA A 266 ? TRP A 270 ? ALA A 266 TRP A 270 5 ? 5  
HELX_P HELX_P8  AA8 GLU A 287 ? GLU A 292 ? GLU A 287 GLU A 292 1 ? 6  
HELX_P HELX_P9  AA9 ALA A 309 ? ARG A 319 ? ALA A 309 ARG A 319 1 ? 11 
HELX_P HELX_P10 AB1 SER A 327 ? GLY A 333 ? SER A 327 GLY A 333 1 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
hydrog1  hydrog ? ? C G  10 N1 ? ? ? 1_555 C A  25 N1 ? ? B G  -16 B A  -1 1_555 ? ? ? ? ? ? TYPE_8_PAIR   ? ? ? 
hydrog2  hydrog ? ? C G  10 O6 ? ? ? 1_555 C A  25 N6 ? ? B G  -16 B A  -1 1_555 ? ? ? ? ? ? TYPE_8_PAIR   ? ? ? 
hydrog3  hydrog ? ? C C  11 N3 ? ? ? 1_555 C G  24 N1 ? ? B C  -15 B G  -2 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog4  hydrog ? ? C C  11 N4 ? ? ? 1_555 C G  24 O6 ? ? B C  -15 B G  -2 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog5  hydrog ? ? C C  11 O2 ? ? ? 1_555 C G  24 N2 ? ? B C  -15 B G  -2 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog6  hydrog ? ? C U  12 N3 ? ? ? 1_555 C A  23 N1 ? ? B U  -14 B A  -3 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog7  hydrog ? ? C U  12 O4 ? ? ? 1_555 C A  23 N6 ? ? B U  -14 B A  -3 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog8  hydrog ? ? C C  13 N3 ? ? ? 1_555 C G  22 N1 ? ? B C  -13 B G  -4 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog9  hydrog ? ? C C  13 N4 ? ? ? 1_555 C G  22 O6 ? ? B C  -13 B G  -4 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog10 hydrog ? ? C C  13 O2 ? ? ? 1_555 C G  22 N2 ? ? B C  -13 B G  -4 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog11 hydrog ? ? C G  14 N1 ? ? ? 1_555 C C  21 N3 ? ? B G  -12 B C  -5 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog12 hydrog ? ? C G  14 N2 ? ? ? 1_555 C C  21 O2 ? ? B G  -12 B C  -5 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog13 hydrog ? ? C G  14 O6 ? ? ? 1_555 C C  21 N4 ? ? B G  -12 B C  -5 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog14 hydrog ? ? C G  15 N2 ? ? ? 1_555 C C  20 O2 ? ? B G  -11 B C  -6 1_555 ? ? ? ? ? ? 'G-C PAIR'    ? ? ? 
hydrog15 hydrog ? ? C U  16 O2 ? ? ? 1_555 C G  19 N1 ? ? B U  -10 B G  -7 1_555 ? ? ? ? ? ? 'U-G MISPAIR' ? ? ? 
hydrog16 hydrog ? ? B DA 23 N6 ? ? ? 1_555 C G  37 O6 ? ? C DA -10 B G  11 1_555 ? ? ? ? ? ? TYPE_9_PAIR   ? ? ? 
hydrog17 hydrog ? ? B DA 23 N7 ? ? ? 1_555 C G  37 N1 ? ? C DA -10 B G  11 1_555 ? ? ? ? ? ? TYPE_9_PAIR   ? ? ? 
hydrog18 hydrog ? ? B DC 24 N4 ? ? ? 1_555 C G  35 O6 ? ? C DC -9  B G  9  1_555 ? ? ? ? ? ? 'DC-G PAIR'   ? ? ? 
hydrog19 hydrog ? ? B DT 26 N3 ? ? ? 1_555 C A  33 N1 ? ? C DT -7  B A  7  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog20 hydrog ? ? B DT 26 O4 ? ? ? 1_555 C A  33 N6 ? ? C DT -7  B A  7  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog21 hydrog ? ? B DA 27 N1 ? ? ? 1_555 C U  32 N3 ? ? C DA -6  B U  6  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog22 hydrog ? ? B DA 27 N6 ? ? ? 1_555 C U  32 O4 ? ? C DA -6  B U  6  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog23 hydrog ? ? B DG 28 N1 ? ? ? 1_555 C C  31 N3 ? ? C DG -5  B C  5  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog24 hydrog ? ? B DG 28 N2 ? ? ? 1_555 C C  31 O2 ? ? C DG -5  B C  5  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog25 hydrog ? ? B DG 28 O6 ? ? ? 1_555 C C  31 N4 ? ? C DG -5  B C  5  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog26 hydrog ? ? B DG 29 N1 ? ? ? 1_555 C C  30 N3 ? ? C DG -4  B C  4  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog27 hydrog ? ? B DG 29 N2 ? ? ? 1_555 C C  30 O2 ? ? C DG -4  B C  4  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog28 hydrog ? ? B DG 29 O6 ? ? ? 1_555 C C  30 N4 ? ? C DG -4  B C  4  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog29 hydrog ? ? B DG 30 N1 ? ? ? 1_555 C C  29 N3 ? ? C DG -3  B C  3  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog30 hydrog ? ? B DG 30 N2 ? ? ? 1_555 C C  29 O2 ? ? C DG -3  B C  3  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog31 hydrog ? ? B DG 30 O6 ? ? ? 1_555 C C  29 N4 ? ? C DG -3  B C  3  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog32 hydrog ? ? B DG 31 N2 ? ? ? 1_555 C C  28 O2 ? ? C DG -2  B C  2  1_555 ? ? ? ? ? ? 'DG-C PAIR'   ? ? ? 
hydrog33 hydrog ? ? B DA 32 N1 ? ? ? 1_555 C U  27 N3 ? ? C DA -1  B U  1  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog34 hydrog ? ? B DA 32 N6 ? ? ? 1_555 C U  27 O4 ? ? C DA -1  B U  1  1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog35 hydrog ? ? B DG 33 O6 ? ? ? 1_555 D DC 10 N4 ? ? C DG 0   D DC 0  1_555 ? ? ? ? ? ? 'DG-DC PAIR'  ? ? ? 
hydrog36 hydrog ? ? B DA 34 N6 ? ? ? 1_555 D DT 8  O4 ? ? C DA 1   D DT -2 1_555 ? ? ? ? ? ? 'DA-DT PAIR'  ? ? ? 
hydrog37 hydrog ? ? B DA 35 N1 ? ? ? 1_555 D DT 8  N3 ? ? C DA 2   D DT -2 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog38 hydrog ? ? B DA 35 N6 ? ? ? 1_555 D DT 8  O4 ? ? C DA 2   D DT -2 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog39 hydrog ? ? B DT 36 N3 ? ? ? 1_555 D DA 7  N1 ? ? C DT 3   D DA -3 1_555 ? ? ? ? ? ? 'DT-DA PAIR'  ? ? ? 
hydrog40 hydrog ? ? B DT 37 N3 ? ? ? 1_555 D DA 6  N1 ? ? C DT 4   D DA -4 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog41 hydrog ? ? B DT 37 O4 ? ? ? 1_555 D DA 6  N6 ? ? C DT 4   D DA -4 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog42 hydrog ? ? B DG 38 N1 ? ? ? 1_555 D DC 5  N3 ? ? C DG 5   D DC -5 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog43 hydrog ? ? B DG 38 N2 ? ? ? 1_555 D DC 5  O2 ? ? C DG 5   D DC -5 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog44 hydrog ? ? B DG 38 O6 ? ? ? 1_555 D DC 5  N4 ? ? C DG 5   D DC -5 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog45 hydrog ? ? B DG 39 N1 ? ? ? 1_555 D DC 4  N3 ? ? C DG 6   D DC -6 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog46 hydrog ? ? B DG 39 N2 ? ? ? 1_555 D DC 4  O2 ? ? C DG 6   D DC -6 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
hydrog47 hydrog ? ? B DG 39 O6 ? ? ? 1_555 D DC 4  N4 ? ? C DG 6   D DC -6 1_555 ? ? ? ? ? ? WATSON-CRICK  ? ? ? 
# 
_struct_conn_type.id          hydrog 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   7 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 198 ? TYR A 199 ? ILE A 198 TYR A 199 
AA1 2 VAL A 340 ? ASP A 342 ? VAL A 340 ASP A 342 
AA1 3 ILE A 347 ? THR A 351 ? ILE A 347 THR A 351 
AA1 4 PRO A 60  ? GLN A 68  ? PRO A 60  GLN A 68  
AA1 5 ASP A 303 ? ASP A 308 ? ASP A 303 ASP A 308 
AA1 6 PRO A 295 ? ILE A 300 ? PRO A 295 ILE A 300 
AA1 7 VAL A 207 ? PRO A 208 ? VAL A 207 PRO A 208 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 198 ? N ILE A 198 O LEU A 341 ? O LEU A 341 
AA1 2 3 N VAL A 340 ? N VAL A 340 O THR A 349 ? O THR A 349 
AA1 3 4 O PHE A 350 ? O PHE A 350 N ALA A 61  ? N ALA A 61  
AA1 4 5 N LEU A 66  ? N LEU A 66  O VAL A 306 ? O VAL A 306 
AA1 5 6 O ILE A 305 ? O ILE A 305 N VAL A 298 ? N VAL A 298 
AA1 6 7 O ILE A 297 ? O ILE A 297 N VAL A 207 ? N VAL A 207 
# 
_pdbx_entry_details.entry_id                   8WS6 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 89  ? ? -69.85  3.27   
2 1 THR A 124 ? ? -142.33 46.56  
3 1 THR A 232 ? ? 22.30   68.34  
4 1 PRO A 243 ? ? -44.74  108.15 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8WS6 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8WS6 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.21 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               147916 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Ternary complex of mini Cas12-1 with 14 nt complementary heteroduplex' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3, 4' 
# 
_em_imaging.entry_id                        8WS6 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1200 
_em_imaging.nominal_defocus_max             5000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8WS6 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8WS6 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A THR 2   ? A THR 2   
3   1 Y 1 A PRO 3   ? A PRO 3   
4   1 Y 1 A LYS 4   ? A LYS 4   
5   1 Y 1 A THR 5   ? A THR 5   
6   1 Y 1 A GLU 6   ? A GLU 6   
7   1 Y 1 A THR 7   ? A THR 7   
8   1 Y 1 A PRO 8   ? A PRO 8   
9   1 Y 1 A VAL 9   ? A VAL 9   
10  1 Y 1 A GLY 10  ? A GLY 10  
11  1 Y 1 A ALA 11  ? A ALA 11  
12  1 Y 1 A LEU 12  ? A LEU 12  
13  1 Y 1 A ILE 13  ? A ILE 13  
14  1 Y 1 A LYS 14  ? A LYS 14  
15  1 Y 1 A LYS 15  ? A LYS 15  
16  1 Y 1 A PHE 16  ? A PHE 16  
17  1 Y 1 A PHE 17  ? A PHE 17  
18  1 Y 1 A PRO 18  ? A PRO 18  
19  1 Y 1 A GLY 19  ? A GLY 19  
20  1 Y 1 A LYS 20  ? A LYS 20  
21  1 Y 1 A ARG 21  ? A ARG 21  
22  1 Y 1 A PHE 22  ? A PHE 22  
23  1 Y 1 A GLN 23  ? A GLN 23  
24  1 Y 1 A LYS 24  ? A LYS 24  
25  1 Y 1 A ASN 25  ? A ASN 25  
26  1 Y 1 A TYR 26  ? A TYR 26  
27  1 Y 1 A LEU 27  ? A LEU 27  
28  1 Y 1 A LYS 28  ? A LYS 28  
29  1 Y 1 A ASP 29  ? A ASP 29  
30  1 Y 1 A ALA 30  ? A ALA 30  
31  1 Y 1 A GLY 31  ? A GLY 31  
32  1 Y 1 A LYS 32  ? A LYS 32  
33  1 Y 1 A LYS 33  ? A LYS 33  
34  1 Y 1 A LEU 34  ? A LEU 34  
35  1 Y 1 A LYS 35  ? A LYS 35  
36  1 Y 1 A ARG 36  ? A ARG 36  
37  1 Y 1 A GLU 37  ? A GLU 37  
38  1 Y 1 A GLY 38  ? A GLY 38  
39  1 Y 1 A GLU 39  ? A GLU 39  
40  1 Y 1 A ALA 40  ? A ALA 40  
41  1 Y 1 A ALA 41  ? A ALA 41  
42  1 Y 1 A ALA 42  ? A ALA 42  
43  1 Y 1 A VAL 43  ? A VAL 43  
44  1 Y 1 A GLU 44  ? A GLU 44  
45  1 Y 1 A TYR 45  ? A TYR 45  
46  1 Y 1 A LEU 46  ? A LEU 46  
47  1 Y 1 A SER 47  ? A SER 47  
48  1 Y 1 A GLY 48  ? A GLY 48  
49  1 Y 1 A LYS 49  ? A LYS 49  
50  1 Y 1 A GLN 50  ? A GLN 50  
51  1 Y 1 A GLU 51  ? A GLU 51  
52  1 Y 1 A ASP 52  ? A ASP 52  
53  1 Y 1 A HIS 53  ? A HIS 53  
54  1 Y 1 A PRO 54  ? A PRO 54  
55  1 Y 1 A ALA 55  ? A ALA 55  
56  1 Y 1 A ASN 56  ? A ASN 56  
57  1 Y 1 A PHE 57  ? A PHE 57  
58  1 Y 1 A ALA 356 ? A ALA 356 
59  1 Y 1 A VAL 357 ? A VAL 357 
60  1 Y 1 A ALA 358 ? A ALA 358 
61  1 Y 1 A VAL 359 ? A VAL 359 
62  1 Y 1 A HIS 360 ? A HIS 360 
63  1 Y 1 A SER 361 ? A SER 361 
64  1 Y 1 A ARG 362 ? A ARG 362 
65  1 Y 1 A LYS 363 ? A LYS 363 
66  1 Y 1 A PRO 364 ? A PRO 364 
67  1 Y 1 A THR 365 ? A THR 365 
68  1 Y 1 A ARG 366 ? A ARG 366 
69  1 Y 1 A GLY 367 ? A GLY 367 
70  1 Y 1 A LYS 368 ? A LYS 368 
71  1 Y 1 A LYS 369 ? A LYS 369 
72  1 Y 1 A SER 370 ? A SER 370 
73  1 Y 1 A LYS 371 ? A LYS 371 
74  1 Y 1 A GLU 372 ? A GLU 372 
75  1 Y 1 A LEU 373 ? A LEU 373 
76  1 Y 1 A LEU 374 ? A LEU 374 
77  1 Y 1 A LEU 375 ? A LEU 375 
78  1 Y 1 A SER 376 ? A SER 376 
79  1 Y 1 A MET 377 ? A MET 377 
80  1 Y 1 A THR 378 ? A THR 378 
81  1 Y 1 A ALA 379 ? A ALA 379 
82  1 Y 1 A GLU 380 ? A GLU 380 
83  1 Y 1 A LYS 381 ? A LYS 381 
84  1 Y 1 A PRO 382 ? A PRO 382 
85  1 Y 1 A HIS 383 ? A HIS 383 
86  1 Y 1 A VAL 384 ? A VAL 384 
87  1 Y 1 A GLY 385 ? A GLY 385 
88  1 Y 1 A LEU 386 ? A LEU 386 
89  1 Y 1 A VAL 387 ? A VAL 387 
90  1 Y 1 A ALA 388 ? A ALA 388 
91  1 Y 1 A ILE 389 ? A ILE 389 
92  1 Y 1 A ASP 390 ? A ASP 390 
93  1 Y 1 A LEU 391 ? A LEU 391 
94  1 Y 1 A GLY 392 ? A GLY 392 
95  1 Y 1 A GLN 393 ? A GLN 393 
96  1 Y 1 A THR 394 ? A THR 394 
97  1 Y 1 A ASN 395 ? A ASN 395 
98  1 Y 1 A PRO 396 ? A PRO 396 
99  1 Y 1 A VAL 397 ? A VAL 397 
100 1 Y 1 A ALA 398 ? A ALA 398 
101 1 Y 1 A ALA 399 ? A ALA 399 
102 1 Y 1 A GLU 400 ? A GLU 400 
103 1 Y 1 A PHE 401 ? A PHE 401 
104 1 Y 1 A SER 402 ? A SER 402 
105 1 Y 1 A ARG 403 ? A ARG 403 
106 1 Y 1 A VAL 404 ? A VAL 404 
107 1 Y 1 A LYS 405 ? A LYS 405 
108 1 Y 1 A ARG 406 ? A ARG 406 
109 1 Y 1 A GLU 407 ? A GLU 407 
110 1 Y 1 A GLY 408 ? A GLY 408 
111 1 Y 1 A GLU 409 ? A GLU 409 
112 1 Y 1 A THR 410 ? A THR 410 
113 1 Y 1 A LEU 411 ? A LEU 411 
114 1 Y 1 A GLN 412 ? A GLN 412 
115 1 Y 1 A ALA 413 ? A ALA 413 
116 1 Y 1 A GLU 414 ? A GLU 414 
117 1 Y 1 A PRO 415 ? A PRO 415 
118 1 Y 1 A LEU 416 ? A LEU 416 
119 1 Y 1 A GLY 417 ? A GLY 417 
120 1 Y 1 A GLN 418 ? A GLN 418 
121 1 Y 1 A ILE 419 ? A ILE 419 
122 1 Y 1 A VAL 420 ? A VAL 420 
123 1 Y 1 A LEU 421 ? A LEU 421 
124 1 Y 1 A PRO 422 ? A PRO 422 
125 1 Y 1 A ASP 423 ? A ASP 423 
126 1 Y 1 A ASP 424 ? A ASP 424 
127 1 Y 1 A LEU 425 ? A LEU 425 
128 1 Y 1 A VAL 426 ? A VAL 426 
129 1 Y 1 A LYS 427 ? A LYS 427 
130 1 Y 1 A ASP 428 ? A ASP 428 
131 1 Y 1 A LEU 429 ? A LEU 429 
132 1 Y 1 A THR 430 ? A THR 430 
133 1 Y 1 A ARG 431 ? A ARG 431 
134 1 Y 1 A TYR 432 ? A TYR 432 
135 1 Y 1 A ARG 433 ? A ARG 433 
136 1 Y 1 A ARG 434 ? A ARG 434 
137 1 Y 1 A ALA 435 ? A ALA 435 
138 1 Y 1 A TRP 436 ? A TRP 436 
139 1 Y 1 A ASP 437 ? A ASP 437 
140 1 Y 1 A ALA 438 ? A ALA 438 
141 1 Y 1 A THR 439 ? A THR 439 
142 1 Y 1 A GLU 440 ? A GLU 440 
143 1 Y 1 A GLU 441 ? A GLU 441 
144 1 Y 1 A GLN 442 ? A GLN 442 
145 1 Y 1 A ILE 443 ? A ILE 443 
146 1 Y 1 A LYS 444 ? A LYS 444 
147 1 Y 1 A ALA 445 ? A ALA 445 
148 1 Y 1 A GLU 446 ? A GLU 446 
149 1 Y 1 A ALA 447 ? A ALA 447 
150 1 Y 1 A ILE 448 ? A ILE 448 
151 1 Y 1 A VAL 449 ? A VAL 449 
152 1 Y 1 A GLN 450 ? A GLN 450 
153 1 Y 1 A LEU 451 ? A LEU 451 
154 1 Y 1 A PRO 452 ? A PRO 452 
155 1 Y 1 A GLU 453 ? A GLU 453 
156 1 Y 1 A GLU 454 ? A GLU 454 
157 1 Y 1 A CYS 455 ? A CYS 455 
158 1 Y 1 A ARG 456 ? A ARG 456 
159 1 Y 1 A ALA 457 ? A ALA 457 
160 1 Y 1 A GLU 458 ? A GLU 458 
161 1 Y 1 A VAL 459 ? A VAL 459 
162 1 Y 1 A VAL 460 ? A VAL 460 
163 1 Y 1 A LYS 461 ? A LYS 461 
164 1 Y 1 A VAL 462 ? A VAL 462 
165 1 Y 1 A ASN 463 ? A ASN 463 
166 1 Y 1 A GLN 464 ? A GLN 464 
167 1 Y 1 A MET 465 ? A MET 465 
168 1 Y 1 A SER 466 ? A SER 466 
169 1 Y 1 A ALA 467 ? A ALA 467 
170 1 Y 1 A GLU 468 ? A GLU 468 
171 1 Y 1 A GLU 469 ? A GLU 469 
172 1 Y 1 A THR 470 ? A THR 470 
173 1 Y 1 A LYS 471 ? A LYS 471 
174 1 Y 1 A HIS 472 ? A HIS 472 
175 1 Y 1 A LEU 473 ? A LEU 473 
176 1 Y 1 A ILE 474 ? A ILE 474 
177 1 Y 1 A LEU 475 ? A LEU 475 
178 1 Y 1 A ASP 476 ? A ASP 476 
179 1 Y 1 A ARG 477 ? A ARG 477 
180 1 Y 1 A GLY 478 ? A GLY 478 
181 1 Y 1 A VAL 479 ? A VAL 479 
182 1 Y 1 A SER 480 ? A SER 480 
183 1 Y 1 A GLY 481 ? A GLY 481 
184 1 Y 1 A ASP 482 ? A ASP 482 
185 1 Y 1 A LEU 483 ? A LEU 483 
186 1 Y 1 A PRO 484 ? A PRO 484 
187 1 Y 1 A TRP 485 ? A TRP 485 
188 1 Y 1 A GLU 486 ? A GLU 486 
189 1 Y 1 A LYS 487 ? A LYS 487 
190 1 Y 1 A MET 488 ? A MET 488 
191 1 Y 1 A THR 489 ? A THR 489 
192 1 Y 1 A SER 490 ? A SER 490 
193 1 Y 1 A ASN 491 ? A ASN 491 
194 1 Y 1 A THR 492 ? A THR 492 
195 1 Y 1 A THR 493 ? A THR 493 
196 1 Y 1 A PHE 494 ? A PHE 494 
197 1 Y 1 A ILE 495 ? A ILE 495 
198 1 Y 1 A SER 496 ? A SER 496 
199 1 Y 1 A ASP 497 ? A ASP 497 
200 1 Y 1 A HIS 498 ? A HIS 498 
201 1 Y 1 A LEU 499 ? A LEU 499 
202 1 Y 1 A LEU 500 ? A LEU 500 
203 1 Y 1 A ALA 501 ? A ALA 501 
204 1 Y 1 A LYS 502 ? A LYS 502 
205 1 Y 1 A GLY 503 ? A GLY 503 
206 1 Y 1 A VAL 504 ? A VAL 504 
207 1 Y 1 A THR 505 ? A THR 505 
208 1 Y 1 A ASP 506 ? A ASP 506 
209 1 Y 1 A GLN 507 ? A GLN 507 
210 1 Y 1 A VAL 508 ? A VAL 508 
211 1 Y 1 A PHE 509 ? A PHE 509 
212 1 Y 1 A PHE 510 ? A PHE 510 
213 1 Y 1 A GLU 511 ? A GLU 511 
214 1 Y 1 A LYS 512 ? A LYS 512 
215 1 Y 1 A LYS 513 ? A LYS 513 
216 1 Y 1 A SER 514 ? A SER 514 
217 1 Y 1 A LYS 515 ? A LYS 515 
218 1 Y 1 A GLY 516 ? A GLY 516 
219 1 Y 1 A LYS 517 ? A LYS 517 
220 1 Y 1 A LYS 518 ? A LYS 518 
221 1 Y 1 A LYS 519 ? A LYS 519 
222 1 Y 1 A GLY 520 ? A GLY 520 
223 1 Y 1 A THR 521 ? A THR 521 
224 1 Y 1 A GLU 522 ? A GLU 522 
225 1 Y 1 A THR 523 ? A THR 523 
226 1 Y 1 A VAL 524 ? A VAL 524 
227 1 Y 1 A LYS 525 ? A LYS 525 
228 1 Y 1 A ARG 526 ? A ARG 526 
229 1 Y 1 A LYS 527 ? A LYS 527 
230 1 Y 1 A ASP 528 ? A ASP 528 
231 1 Y 1 A TYR 529 ? A TYR 529 
232 1 Y 1 A GLY 530 ? A GLY 530 
233 1 Y 1 A TRP 531 ? A TRP 531 
234 1 Y 1 A VAL 532 ? A VAL 532 
235 1 Y 1 A LYS 533 ? A LYS 533 
236 1 Y 1 A LEU 534 ? A LEU 534 
237 1 Y 1 A LEU 535 ? A LEU 535 
238 1 Y 1 A ARG 536 ? A ARG 536 
239 1 Y 1 A PRO 537 ? A PRO 537 
240 1 Y 1 A ARG 538 ? A ARG 538 
241 1 Y 1 A LEU 539 ? A LEU 539 
242 1 Y 1 A SER 540 ? A SER 540 
243 1 Y 1 A GLN 541 ? A GLN 541 
244 1 Y 1 A GLU 542 ? A GLU 542 
245 1 Y 1 A THR 543 ? A THR 543 
246 1 Y 1 A ARG 544 ? A ARG 544 
247 1 Y 1 A LYS 545 ? A LYS 545 
248 1 Y 1 A ALA 546 ? A ALA 546 
249 1 Y 1 A VAL 547 ? A VAL 547 
250 1 Y 1 A ASN 548 ? A ASN 548 
251 1 Y 1 A ASP 549 ? A ASP 549 
252 1 Y 1 A LYS 550 ? A LYS 550 
253 1 Y 1 A THR 551 ? A THR 551 
254 1 Y 1 A TRP 552 ? A TRP 552 
255 1 Y 1 A GLU 553 ? A GLU 553 
256 1 Y 1 A LEU 554 ? A LEU 554 
257 1 Y 1 A LYS 555 ? A LYS 555 
258 1 Y 1 A ARG 556 ? A ARG 556 
259 1 Y 1 A ALA 557 ? A ALA 557 
260 1 Y 1 A SER 558 ? A SER 558 
261 1 Y 1 A THR 559 ? A THR 559 
262 1 Y 1 A GLU 560 ? A GLU 560 
263 1 Y 1 A TYR 561 ? A TYR 561 
264 1 Y 1 A VAL 562 ? A VAL 562 
265 1 Y 1 A ARG 563 ? A ARG 563 
266 1 Y 1 A LEU 564 ? A LEU 564 
267 1 Y 1 A SER 565 ? A SER 565 
268 1 Y 1 A ARG 566 ? A ARG 566 
269 1 Y 1 A ARG 567 ? A ARG 567 
270 1 Y 1 A LYS 568 ? A LYS 568 
271 1 Y 1 A THR 569 ? A THR 569 
272 1 Y 1 A GLU 570 ? A GLU 570 
273 1 Y 1 A LEU 571 ? A LEU 571 
274 1 Y 1 A ALA 572 ? A ALA 572 
275 1 Y 1 A ARG 573 ? A ARG 573 
276 1 Y 1 A ARG 574 ? A ARG 574 
277 1 Y 1 A CYS 575 ? A CYS 575 
278 1 Y 1 A VAL 576 ? A VAL 576 
279 1 Y 1 A ASN 577 ? A ASN 577 
280 1 Y 1 A TYR 578 ? A TYR 578 
281 1 Y 1 A ILE 579 ? A ILE 579 
282 1 Y 1 A VAL 580 ? A VAL 580 
283 1 Y 1 A ARG 581 ? A ARG 581 
284 1 Y 1 A GLU 582 ? A GLU 582 
285 1 Y 1 A THR 583 ? A THR 583 
286 1 Y 1 A LYS 584 ? A LYS 584 
287 1 Y 1 A ARG 585 ? A ARG 585 
288 1 Y 1 A TRP 586 ? A TRP 586 
289 1 Y 1 A THR 587 ? A THR 587 
290 1 Y 1 A GLN 588 ? A GLN 588 
291 1 Y 1 A CYS 589 ? A CYS 589 
292 1 Y 1 A GLU 590 ? A GLU 590 
293 1 Y 1 A ASP 591 ? A ASP 591 
294 1 Y 1 A ILE 592 ? A ILE 592 
295 1 Y 1 A ALA 593 ? A ALA 593 
296 1 Y 1 A ILE 594 ? A ILE 594 
297 1 Y 1 A VAL 595 ? A VAL 595 
298 1 Y 1 A ILE 596 ? A ILE 596 
299 1 Y 1 A GLU 597 ? A GLU 597 
300 1 Y 1 A ASP 598 ? A ASP 598 
301 1 Y 1 A LEU 599 ? A LEU 599 
302 1 Y 1 A ASN 600 ? A ASN 600 
303 1 Y 1 A VAL 601 ? A VAL 601 
304 1 Y 1 A ARG 602 ? A ARG 602 
305 1 Y 1 A PHE 603 ? A PHE 603 
306 1 Y 1 A PHE 604 ? A PHE 604 
307 1 Y 1 A HIS 605 ? A HIS 605 
308 1 Y 1 A GLY 606 ? A GLY 606 
309 1 Y 1 A SER 607 ? A SER 607 
310 1 Y 1 A GLY 608 ? A GLY 608 
311 1 Y 1 A GLU 609 ? A GLU 609 
312 1 Y 1 A ARG 610 ? A ARG 610 
313 1 Y 1 A PRO 611 ? A PRO 611 
314 1 Y 1 A ASP 612 ? A ASP 612 
315 1 Y 1 A GLY 613 ? A GLY 613 
316 1 Y 1 A TRP 614 ? A TRP 614 
317 1 Y 1 A ASP 615 ? A ASP 615 
318 1 Y 1 A ASN 616 ? A ASN 616 
319 1 Y 1 A PHE 617 ? A PHE 617 
320 1 Y 1 A PHE 618 ? A PHE 618 
321 1 Y 1 A ILE 619 ? A ILE 619 
322 1 Y 1 A SER 620 ? A SER 620 
323 1 Y 1 A LYS 621 ? A LYS 621 
324 1 Y 1 A ARG 622 ? A ARG 622 
325 1 Y 1 A GLU 623 ? A GLU 623 
326 1 Y 1 A ASN 624 ? A ASN 624 
327 1 Y 1 A ARG 625 ? A ARG 625 
328 1 Y 1 A TRP 626 ? A TRP 626 
329 1 Y 1 A PHE 627 ? A PHE 627 
330 1 Y 1 A ILE 628 ? A ILE 628 
331 1 Y 1 A GLN 629 ? A GLN 629 
332 1 Y 1 A VAL 630 ? A VAL 630 
333 1 Y 1 A LEU 631 ? A LEU 631 
334 1 Y 1 A HIS 632 ? A HIS 632 
335 1 Y 1 A LYS 633 ? A LYS 633 
336 1 Y 1 A ALA 634 ? A ALA 634 
337 1 Y 1 A PHE 635 ? A PHE 635 
338 1 Y 1 A SER 636 ? A SER 636 
339 1 Y 1 A ASP 637 ? A ASP 637 
340 1 Y 1 A LEU 638 ? A LEU 638 
341 1 Y 1 A ALA 639 ? A ALA 639 
342 1 Y 1 A LEU 640 ? A LEU 640 
343 1 Y 1 A HIS 641 ? A HIS 641 
344 1 Y 1 A ARG 642 ? A ARG 642 
345 1 Y 1 A GLY 643 ? A GLY 643 
346 1 Y 1 A LEU 644 ? A LEU 644 
347 1 Y 1 A PRO 645 ? A PRO 645 
348 1 Y 1 A VAL 646 ? A VAL 646 
349 1 Y 1 A ILE 647 ? A ILE 647 
350 1 Y 1 A GLU 648 ? A GLU 648 
351 1 Y 1 A ALA 649 ? A ALA 649 
352 1 Y 1 A ASN 650 ? A ASN 650 
353 1 Y 1 A PRO 651 ? A PRO 651 
354 1 Y 1 A ALA 652 ? A ALA 652 
355 1 Y 1 A ARG 653 ? A ARG 653 
356 1 Y 1 A THR 654 ? A THR 654 
357 1 Y 1 A SER 655 ? A SER 655 
358 1 Y 1 A ILE 656 ? A ILE 656 
359 1 Y 1 A THR 657 ? A THR 657 
360 1 Y 1 A CYS 658 ? A CYS 658 
361 1 Y 1 A ILE 659 ? A ILE 659 
362 1 Y 1 A ARG 660 ? A ARG 660 
363 1 Y 1 A CYS 661 ? A CYS 661 
364 1 Y 1 A GLY 662 ? A GLY 662 
365 1 Y 1 A HIS 663 ? A HIS 663 
366 1 Y 1 A CYS 664 ? A CYS 664 
367 1 Y 1 A ASP 665 ? A ASP 665 
368 1 Y 1 A ARG 666 ? A ARG 666 
369 1 Y 1 A ASN 667 ? A ASN 667 
370 1 Y 1 A ASN 668 ? A ASN 668 
371 1 Y 1 A ARG 669 ? A ARG 669 
372 1 Y 1 A HIS 670 ? A HIS 670 
373 1 Y 1 A GLY 671 ? A GLY 671 
374 1 Y 1 A GLU 672 ? A GLU 672 
375 1 Y 1 A MET 673 ? A MET 673 
376 1 Y 1 A PHE 674 ? A PHE 674 
377 1 Y 1 A LEU 675 ? A LEU 675 
378 1 Y 1 A CYS 676 ? A CYS 676 
379 1 Y 1 A LEU 677 ? A LEU 677 
380 1 Y 1 A SER 678 ? A SER 678 
381 1 Y 1 A CYS 679 ? A CYS 679 
382 1 Y 1 A ASN 680 ? A ASN 680 
383 1 Y 1 A ASP 681 ? A ASP 681 
384 1 Y 1 A LEU 682 ? A LEU 682 
385 1 Y 1 A ARG 683 ? A ARG 683 
386 1 Y 1 A HIS 684 ? A HIS 684 
387 1 Y 1 A ALA 685 ? A ALA 685 
388 1 Y 1 A ASP 686 ? A ASP 686 
389 1 Y 1 A ARG 687 ? A ARG 687 
390 1 Y 1 A GLU 688 ? A GLU 688 
391 1 Y 1 A ILE 689 ? A ILE 689 
392 1 Y 1 A ALA 690 ? A ALA 690 
393 1 Y 1 A THR 691 ? A THR 691 
394 1 Y 1 A ARG 692 ? A ARG 692 
395 1 Y 1 A ASN 693 ? A ASN 693 
396 1 Y 1 A LEU 694 ? A LEU 694 
397 1 Y 1 A THR 695 ? A THR 695 
398 1 Y 1 A ARG 696 ? A ARG 696 
399 1 Y 1 A VAL 697 ? A VAL 697 
400 1 Y 1 A ALA 698 ? A ALA 698 
401 1 Y 1 A VAL 699 ? A VAL 699 
402 1 Y 1 A THR 700 ? A THR 700 
403 1 Y 1 A GLY 701 ? A GLY 701 
404 1 Y 1 A GLU 702 ? A GLU 702 
405 1 Y 1 A MET 703 ? A MET 703 
406 1 Y 1 A ILE 704 ? A ILE 704 
407 1 Y 1 A PRO 705 ? A PRO 705 
408 1 Y 1 A ARG 706 ? A ARG 706 
409 1 Y 1 A ARG 707 ? A ARG 707 
410 1 Y 1 A ILE 708 ? A ILE 708 
411 1 Y 1 A GLU 709 ? A GLU 709 
412 1 Y 1 A PRO 710 ? A PRO 710 
413 1 Y 1 A GLY 711 ? A GLY 711 
414 1 Y 1 A GLU 712 ? A GLU 712 
415 1 Y 1 A GLN 713 ? A GLN 713 
416 1 Y 1 A SER 714 ? A SER 714 
417 1 Y 1 A GLY 715 ? A GLY 715 
418 1 Y 1 A ASP 716 ? A ASP 716 
419 1 Y 1 A THR 717 ? A THR 717 
420 1 Y 1 A LYS 718 ? A LYS 718 
421 1 Y 1 A LYS 719 ? A LYS 719 
422 1 Y 1 A ALA 720 ? A ALA 720 
423 1 Y 1 A ARG 721 ? A ARG 721 
424 1 Y 1 A SER 722 ? A SER 722 
425 1 Y 1 A ALA 723 ? A ALA 723 
426 1 Y 1 A ARG 724 ? A ARG 724 
427 1 Y 1 A LYS 725 ? A LYS 725 
428 1 Y 1 A GLY 726 ? A GLY 726 
429 1 Y 1 A LYS 727 ? A LYS 727 
430 1 Y 1 A LYS 728 ? A LYS 728 
431 1 Y 1 A ALA 729 ? A ALA 729 
432 1 Y 1 A VAL 730 ? A VAL 730 
433 1 Y 1 A ILE 731 ? A ILE 731 
434 1 Y 1 A SER 732 ? A SER 732 
435 1 Y 1 A LYS 733 ? A LYS 733 
436 1 Y 1 A ARG 734 ? A ARG 734 
437 1 Y 1 A GLU 735 ? A GLU 735 
438 1 Y 1 A ALA 736 ? A ALA 736 
439 1 Y 1 A ALA 737 ? A ALA 737 
440 1 Y 1 C DC  -32 ? B DC  1   
441 1 Y 1 C DT  -31 ? B DT  2   
442 1 Y 1 C DG  -30 ? B DG  3   
443 1 Y 1 C DC  -29 ? B DC  4   
444 1 Y 1 C DC  -28 ? B DC  5   
445 1 Y 1 C DC  -27 ? B DC  6   
446 1 Y 1 C DT  -26 ? B DT  7   
447 1 Y 1 C DT  -25 ? B DT  8   
448 1 Y 1 C DG  -24 ? B DG  9   
449 1 Y 1 C DC  -23 ? B DC  10  
450 1 Y 1 C DA  -22 ? B DA  11  
451 1 Y 1 C DA  -21 ? B DA  12  
452 1 Y 1 C DG  -20 ? B DG  13  
453 1 Y 1 C DA  -19 ? B DA  14  
454 1 Y 1 C DA  -18 ? B DA  15  
455 1 Y 1 C DG  -17 ? B DG  16  
456 1 Y 1 C DT  -16 ? B DT  17  
457 1 Y 1 C DC  -15 ? B DC  18  
458 1 Y 1 C DC  -14 ? B DC  19  
459 1 Y 1 C DA  -13 ? B DA  20  
460 1 Y 1 C DC  7   ? B DC  40  
461 1 Y 1 C DC  8   ? B DC  41  
462 1 Y 1 C DA  9   ? B DA  42  
463 1 Y 1 B U   -25 ? C U   1   
464 1 Y 1 B C   -24 ? C C   2   
465 1 Y 1 B A   -23 ? C A   3   
466 1 Y 1 B A   -22 ? C A   4   
467 1 Y 1 B C   -21 ? C C   5   
468 1 Y 1 B G   -20 ? C G   6   
469 1 Y 1 B C   12  ? C C   38  
470 1 Y 1 B U   13  ? C U   39  
471 1 Y 1 B G   14  ? C G   40  
472 1 Y 1 B C   15  ? C C   41  
473 1 Y 1 B U   16  ? C U   42  
474 1 Y 1 B G   17  ? C G   43  
475 1 Y 1 B A   18  ? C A   44  
476 1 Y 1 B A   19  ? C A   45  
477 1 Y 1 B G   20  ? C G   46  
478 1 Y 1 D DT  -9  ? D DT  1   
479 1 Y 1 D DG  -8  ? D DG  2   
480 1 Y 1 D DG  -7  ? D DG  3   
481 1 Y 1 D DC  2   ? D DC  12  
482 1 Y 1 D DC  3   ? D DC  13  
483 1 Y 1 D DC  4   ? D DC  14  
484 1 Y 1 D DC  5   ? D DC  15  
485 1 Y 1 D DT  6   ? D DT  16  
486 1 Y 1 D DA  7   ? D DA  17  
487 1 Y 1 D DC  8   ? D DC  18  
488 1 Y 1 D DG  9   ? D DG  19  
489 1 Y 1 D DT  10  ? D DT  20  
490 1 Y 1 D DG  11  ? D DG  21  
491 1 Y 1 D DC  12  ? D DC  22  
492 1 Y 1 D DT  13  ? D DT  23  
493 1 Y 1 D DG  14  ? D DG  24  
494 1 Y 1 D DG  15  ? D DG  25  
495 1 Y 1 D DA  16  ? D DA  26  
496 1 Y 1 D DC  17  ? D DC  27  
497 1 Y 1 D DT  18  ? D DT  28  
498 1 Y 1 D DT  19  ? D DT  29  
499 1 Y 1 D DC  20  ? D DC  30  
500 1 Y 1 D DT  21  ? D DT  31  
501 1 Y 1 D DT  22  ? D DT  32  
502 1 Y 1 D DG  23  ? D DG  33  
503 1 Y 1 D DC  24  ? D DC  34  
504 1 Y 1 D DA  25  ? D DA  35  
505 1 Y 1 D DA  26  ? D DA  36  
506 1 Y 1 D DG  27  ? D DG  37  
507 1 Y 1 D DG  28  ? D DG  38  
508 1 Y 1 D DG  29  ? D DG  39  
509 1 Y 1 D DC  30  ? D DC  40  
510 1 Y 1 D DA  31  ? D DA  41  
511 1 Y 1 D DG  32  ? D DG  42  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A   OP3    O N N 1   
A   P      P N N 2   
A   OP1    O N N 3   
A   OP2    O N N 4   
A   "O5'"  O N N 5   
A   "C5'"  C N N 6   
A   "C4'"  C N R 7   
A   "O4'"  O N N 8   
A   "C3'"  C N S 9   
A   "O3'"  O N N 10  
A   "C2'"  C N R 11  
A   "O2'"  O N N 12  
A   "C1'"  C N R 13  
A   N9     N Y N 14  
A   C8     C Y N 15  
A   N7     N Y N 16  
A   C5     C Y N 17  
A   C6     C Y N 18  
A   N6     N N N 19  
A   N1     N Y N 20  
A   C2     C Y N 21  
A   N3     N Y N 22  
A   C4     C Y N 23  
A   HOP3   H N N 24  
A   HOP2   H N N 25  
A   "H5'"  H N N 26  
A   "H5''" H N N 27  
A   "H4'"  H N N 28  
A   "H3'"  H N N 29  
A   "HO3'" H N N 30  
A   "H2'"  H N N 31  
A   "HO2'" H N N 32  
A   "H1'"  H N N 33  
A   H8     H N N 34  
A   H61    H N N 35  
A   H62    H N N 36  
A   H2     H N N 37  
ALA N      N N N 38  
ALA CA     C N S 39  
ALA C      C N N 40  
ALA O      O N N 41  
ALA CB     C N N 42  
ALA OXT    O N N 43  
ALA H      H N N 44  
ALA H2     H N N 45  
ALA HA     H N N 46  
ALA HB1    H N N 47  
ALA HB2    H N N 48  
ALA HB3    H N N 49  
ALA HXT    H N N 50  
ARG N      N N N 51  
ARG CA     C N S 52  
ARG C      C N N 53  
ARG O      O N N 54  
ARG CB     C N N 55  
ARG CG     C N N 56  
ARG CD     C N N 57  
ARG NE     N N N 58  
ARG CZ     C N N 59  
ARG NH1    N N N 60  
ARG NH2    N N N 61  
ARG OXT    O N N 62  
ARG H      H N N 63  
ARG H2     H N N 64  
ARG HA     H N N 65  
ARG HB2    H N N 66  
ARG HB3    H N N 67  
ARG HG2    H N N 68  
ARG HG3    H N N 69  
ARG HD2    H N N 70  
ARG HD3    H N N 71  
ARG HE     H N N 72  
ARG HH11   H N N 73  
ARG HH12   H N N 74  
ARG HH21   H N N 75  
ARG HH22   H N N 76  
ARG HXT    H N N 77  
ASN N      N N N 78  
ASN CA     C N S 79  
ASN C      C N N 80  
ASN O      O N N 81  
ASN CB     C N N 82  
ASN CG     C N N 83  
ASN OD1    O N N 84  
ASN ND2    N N N 85  
ASN OXT    O N N 86  
ASN H      H N N 87  
ASN H2     H N N 88  
ASN HA     H N N 89  
ASN HB2    H N N 90  
ASN HB3    H N N 91  
ASN HD21   H N N 92  
ASN HD22   H N N 93  
ASN HXT    H N N 94  
ASP N      N N N 95  
ASP CA     C N S 96  
ASP C      C N N 97  
ASP O      O N N 98  
ASP CB     C N N 99  
ASP CG     C N N 100 
ASP OD1    O N N 101 
ASP OD2    O N N 102 
ASP OXT    O N N 103 
ASP H      H N N 104 
ASP H2     H N N 105 
ASP HA     H N N 106 
ASP HB2    H N N 107 
ASP HB3    H N N 108 
ASP HD2    H N N 109 
ASP HXT    H N N 110 
C   OP3    O N N 111 
C   P      P N N 112 
C   OP1    O N N 113 
C   OP2    O N N 114 
C   "O5'"  O N N 115 
C   "C5'"  C N N 116 
C   "C4'"  C N R 117 
C   "O4'"  O N N 118 
C   "C3'"  C N S 119 
C   "O3'"  O N N 120 
C   "C2'"  C N R 121 
C   "O2'"  O N N 122 
C   "C1'"  C N R 123 
C   N1     N N N 124 
C   C2     C N N 125 
C   O2     O N N 126 
C   N3     N N N 127 
C   C4     C N N 128 
C   N4     N N N 129 
C   C5     C N N 130 
C   C6     C N N 131 
C   HOP3   H N N 132 
C   HOP2   H N N 133 
C   "H5'"  H N N 134 
C   "H5''" H N N 135 
C   "H4'"  H N N 136 
C   "H3'"  H N N 137 
C   "HO3'" H N N 138 
C   "H2'"  H N N 139 
C   "HO2'" H N N 140 
C   "H1'"  H N N 141 
C   H41    H N N 142 
C   H42    H N N 143 
C   H5     H N N 144 
C   H6     H N N 145 
CYS N      N N N 146 
CYS CA     C N R 147 
CYS C      C N N 148 
CYS O      O N N 149 
CYS CB     C N N 150 
CYS SG     S N N 151 
CYS OXT    O N N 152 
CYS H      H N N 153 
CYS H2     H N N 154 
CYS HA     H N N 155 
CYS HB2    H N N 156 
CYS HB3    H N N 157 
CYS HG     H N N 158 
CYS HXT    H N N 159 
DA  OP3    O N N 160 
DA  P      P N N 161 
DA  OP1    O N N 162 
DA  OP2    O N N 163 
DA  "O5'"  O N N 164 
DA  "C5'"  C N N 165 
DA  "C4'"  C N R 166 
DA  "O4'"  O N N 167 
DA  "C3'"  C N S 168 
DA  "O3'"  O N N 169 
DA  "C2'"  C N N 170 
DA  "C1'"  C N R 171 
DA  N9     N Y N 172 
DA  C8     C Y N 173 
DA  N7     N Y N 174 
DA  C5     C Y N 175 
DA  C6     C Y N 176 
DA  N6     N N N 177 
DA  N1     N Y N 178 
DA  C2     C Y N 179 
DA  N3     N Y N 180 
DA  C4     C Y N 181 
DA  HOP3   H N N 182 
DA  HOP2   H N N 183 
DA  "H5'"  H N N 184 
DA  "H5''" H N N 185 
DA  "H4'"  H N N 186 
DA  "H3'"  H N N 187 
DA  "HO3'" H N N 188 
DA  "H2'"  H N N 189 
DA  "H2''" H N N 190 
DA  "H1'"  H N N 191 
DA  H8     H N N 192 
DA  H61    H N N 193 
DA  H62    H N N 194 
DA  H2     H N N 195 
DC  OP3    O N N 196 
DC  P      P N N 197 
DC  OP1    O N N 198 
DC  OP2    O N N 199 
DC  "O5'"  O N N 200 
DC  "C5'"  C N N 201 
DC  "C4'"  C N R 202 
DC  "O4'"  O N N 203 
DC  "C3'"  C N S 204 
DC  "O3'"  O N N 205 
DC  "C2'"  C N N 206 
DC  "C1'"  C N R 207 
DC  N1     N N N 208 
DC  C2     C N N 209 
DC  O2     O N N 210 
DC  N3     N N N 211 
DC  C4     C N N 212 
DC  N4     N N N 213 
DC  C5     C N N 214 
DC  C6     C N N 215 
DC  HOP3   H N N 216 
DC  HOP2   H N N 217 
DC  "H5'"  H N N 218 
DC  "H5''" H N N 219 
DC  "H4'"  H N N 220 
DC  "H3'"  H N N 221 
DC  "HO3'" H N N 222 
DC  "H2'"  H N N 223 
DC  "H2''" H N N 224 
DC  "H1'"  H N N 225 
DC  H41    H N N 226 
DC  H42    H N N 227 
DC  H5     H N N 228 
DC  H6     H N N 229 
DG  OP3    O N N 230 
DG  P      P N N 231 
DG  OP1    O N N 232 
DG  OP2    O N N 233 
DG  "O5'"  O N N 234 
DG  "C5'"  C N N 235 
DG  "C4'"  C N R 236 
DG  "O4'"  O N N 237 
DG  "C3'"  C N S 238 
DG  "O3'"  O N N 239 
DG  "C2'"  C N N 240 
DG  "C1'"  C N R 241 
DG  N9     N Y N 242 
DG  C8     C Y N 243 
DG  N7     N Y N 244 
DG  C5     C Y N 245 
DG  C6     C N N 246 
DG  O6     O N N 247 
DG  N1     N N N 248 
DG  C2     C N N 249 
DG  N2     N N N 250 
DG  N3     N N N 251 
DG  C4     C Y N 252 
DG  HOP3   H N N 253 
DG  HOP2   H N N 254 
DG  "H5'"  H N N 255 
DG  "H5''" H N N 256 
DG  "H4'"  H N N 257 
DG  "H3'"  H N N 258 
DG  "HO3'" H N N 259 
DG  "H2'"  H N N 260 
DG  "H2''" H N N 261 
DG  "H1'"  H N N 262 
DG  H8     H N N 263 
DG  H1     H N N 264 
DG  H21    H N N 265 
DG  H22    H N N 266 
DT  OP3    O N N 267 
DT  P      P N N 268 
DT  OP1    O N N 269 
DT  OP2    O N N 270 
DT  "O5'"  O N N 271 
DT  "C5'"  C N N 272 
DT  "C4'"  C N R 273 
DT  "O4'"  O N N 274 
DT  "C3'"  C N S 275 
DT  "O3'"  O N N 276 
DT  "C2'"  C N N 277 
DT  "C1'"  C N R 278 
DT  N1     N N N 279 
DT  C2     C N N 280 
DT  O2     O N N 281 
DT  N3     N N N 282 
DT  C4     C N N 283 
DT  O4     O N N 284 
DT  C5     C N N 285 
DT  C7     C N N 286 
DT  C6     C N N 287 
DT  HOP3   H N N 288 
DT  HOP2   H N N 289 
DT  "H5'"  H N N 290 
DT  "H5''" H N N 291 
DT  "H4'"  H N N 292 
DT  "H3'"  H N N 293 
DT  "HO3'" H N N 294 
DT  "H2'"  H N N 295 
DT  "H2''" H N N 296 
DT  "H1'"  H N N 297 
DT  H3     H N N 298 
DT  H71    H N N 299 
DT  H72    H N N 300 
DT  H73    H N N 301 
DT  H6     H N N 302 
G   OP3    O N N 303 
G   P      P N N 304 
G   OP1    O N N 305 
G   OP2    O N N 306 
G   "O5'"  O N N 307 
G   "C5'"  C N N 308 
G   "C4'"  C N R 309 
G   "O4'"  O N N 310 
G   "C3'"  C N S 311 
G   "O3'"  O N N 312 
G   "C2'"  C N R 313 
G   "O2'"  O N N 314 
G   "C1'"  C N R 315 
G   N9     N Y N 316 
G   C8     C Y N 317 
G   N7     N Y N 318 
G   C5     C Y N 319 
G   C6     C N N 320 
G   O6     O N N 321 
G   N1     N N N 322 
G   C2     C N N 323 
G   N2     N N N 324 
G   N3     N N N 325 
G   C4     C Y N 326 
G   HOP3   H N N 327 
G   HOP2   H N N 328 
G   "H5'"  H N N 329 
G   "H5''" H N N 330 
G   "H4'"  H N N 331 
G   "H3'"  H N N 332 
G   "HO3'" H N N 333 
G   "H2'"  H N N 334 
G   "HO2'" H N N 335 
G   "H1'"  H N N 336 
G   H8     H N N 337 
G   H1     H N N 338 
G   H21    H N N 339 
G   H22    H N N 340 
GLN N      N N N 341 
GLN CA     C N S 342 
GLN C      C N N 343 
GLN O      O N N 344 
GLN CB     C N N 345 
GLN CG     C N N 346 
GLN CD     C N N 347 
GLN OE1    O N N 348 
GLN NE2    N N N 349 
GLN OXT    O N N 350 
GLN H      H N N 351 
GLN H2     H N N 352 
GLN HA     H N N 353 
GLN HB2    H N N 354 
GLN HB3    H N N 355 
GLN HG2    H N N 356 
GLN HG3    H N N 357 
GLN HE21   H N N 358 
GLN HE22   H N N 359 
GLN HXT    H N N 360 
GLU N      N N N 361 
GLU CA     C N S 362 
GLU C      C N N 363 
GLU O      O N N 364 
GLU CB     C N N 365 
GLU CG     C N N 366 
GLU CD     C N N 367 
GLU OE1    O N N 368 
GLU OE2    O N N 369 
GLU OXT    O N N 370 
GLU H      H N N 371 
GLU H2     H N N 372 
GLU HA     H N N 373 
GLU HB2    H N N 374 
GLU HB3    H N N 375 
GLU HG2    H N N 376 
GLU HG3    H N N 377 
GLU HE2    H N N 378 
GLU HXT    H N N 379 
GLY N      N N N 380 
GLY CA     C N N 381 
GLY C      C N N 382 
GLY O      O N N 383 
GLY OXT    O N N 384 
GLY H      H N N 385 
GLY H2     H N N 386 
GLY HA2    H N N 387 
GLY HA3    H N N 388 
GLY HXT    H N N 389 
HIS N      N N N 390 
HIS CA     C N S 391 
HIS C      C N N 392 
HIS O      O N N 393 
HIS CB     C N N 394 
HIS CG     C Y N 395 
HIS ND1    N Y N 396 
HIS CD2    C Y N 397 
HIS CE1    C Y N 398 
HIS NE2    N Y N 399 
HIS OXT    O N N 400 
HIS H      H N N 401 
HIS H2     H N N 402 
HIS HA     H N N 403 
HIS HB2    H N N 404 
HIS HB3    H N N 405 
HIS HD1    H N N 406 
HIS HD2    H N N 407 
HIS HE1    H N N 408 
HIS HE2    H N N 409 
HIS HXT    H N N 410 
ILE N      N N N 411 
ILE CA     C N S 412 
ILE C      C N N 413 
ILE O      O N N 414 
ILE CB     C N S 415 
ILE CG1    C N N 416 
ILE CG2    C N N 417 
ILE CD1    C N N 418 
ILE OXT    O N N 419 
ILE H      H N N 420 
ILE H2     H N N 421 
ILE HA     H N N 422 
ILE HB     H N N 423 
ILE HG12   H N N 424 
ILE HG13   H N N 425 
ILE HG21   H N N 426 
ILE HG22   H N N 427 
ILE HG23   H N N 428 
ILE HD11   H N N 429 
ILE HD12   H N N 430 
ILE HD13   H N N 431 
ILE HXT    H N N 432 
LEU N      N N N 433 
LEU CA     C N S 434 
LEU C      C N N 435 
LEU O      O N N 436 
LEU CB     C N N 437 
LEU CG     C N N 438 
LEU CD1    C N N 439 
LEU CD2    C N N 440 
LEU OXT    O N N 441 
LEU H      H N N 442 
LEU H2     H N N 443 
LEU HA     H N N 444 
LEU HB2    H N N 445 
LEU HB3    H N N 446 
LEU HG     H N N 447 
LEU HD11   H N N 448 
LEU HD12   H N N 449 
LEU HD13   H N N 450 
LEU HD21   H N N 451 
LEU HD22   H N N 452 
LEU HD23   H N N 453 
LEU HXT    H N N 454 
LYS N      N N N 455 
LYS CA     C N S 456 
LYS C      C N N 457 
LYS O      O N N 458 
LYS CB     C N N 459 
LYS CG     C N N 460 
LYS CD     C N N 461 
LYS CE     C N N 462 
LYS NZ     N N N 463 
LYS OXT    O N N 464 
LYS H      H N N 465 
LYS H2     H N N 466 
LYS HA     H N N 467 
LYS HB2    H N N 468 
LYS HB3    H N N 469 
LYS HG2    H N N 470 
LYS HG3    H N N 471 
LYS HD2    H N N 472 
LYS HD3    H N N 473 
LYS HE2    H N N 474 
LYS HE3    H N N 475 
LYS HZ1    H N N 476 
LYS HZ2    H N N 477 
LYS HZ3    H N N 478 
LYS HXT    H N N 479 
MET N      N N N 480 
MET CA     C N S 481 
MET C      C N N 482 
MET O      O N N 483 
MET CB     C N N 484 
MET CG     C N N 485 
MET SD     S N N 486 
MET CE     C N N 487 
MET OXT    O N N 488 
MET H      H N N 489 
MET H2     H N N 490 
MET HA     H N N 491 
MET HB2    H N N 492 
MET HB3    H N N 493 
MET HG2    H N N 494 
MET HG3    H N N 495 
MET HE1    H N N 496 
MET HE2    H N N 497 
MET HE3    H N N 498 
MET HXT    H N N 499 
PHE N      N N N 500 
PHE CA     C N S 501 
PHE C      C N N 502 
PHE O      O N N 503 
PHE CB     C N N 504 
PHE CG     C Y N 505 
PHE CD1    C Y N 506 
PHE CD2    C Y N 507 
PHE CE1    C Y N 508 
PHE CE2    C Y N 509 
PHE CZ     C Y N 510 
PHE OXT    O N N 511 
PHE H      H N N 512 
PHE H2     H N N 513 
PHE HA     H N N 514 
PHE HB2    H N N 515 
PHE HB3    H N N 516 
PHE HD1    H N N 517 
PHE HD2    H N N 518 
PHE HE1    H N N 519 
PHE HE2    H N N 520 
PHE HZ     H N N 521 
PHE HXT    H N N 522 
PRO N      N N N 523 
PRO CA     C N S 524 
PRO C      C N N 525 
PRO O      O N N 526 
PRO CB     C N N 527 
PRO CG     C N N 528 
PRO CD     C N N 529 
PRO OXT    O N N 530 
PRO H      H N N 531 
PRO HA     H N N 532 
PRO HB2    H N N 533 
PRO HB3    H N N 534 
PRO HG2    H N N 535 
PRO HG3    H N N 536 
PRO HD2    H N N 537 
PRO HD3    H N N 538 
PRO HXT    H N N 539 
SER N      N N N 540 
SER CA     C N S 541 
SER C      C N N 542 
SER O      O N N 543 
SER CB     C N N 544 
SER OG     O N N 545 
SER OXT    O N N 546 
SER H      H N N 547 
SER H2     H N N 548 
SER HA     H N N 549 
SER HB2    H N N 550 
SER HB3    H N N 551 
SER HG     H N N 552 
SER HXT    H N N 553 
THR N      N N N 554 
THR CA     C N S 555 
THR C      C N N 556 
THR O      O N N 557 
THR CB     C N R 558 
THR OG1    O N N 559 
THR CG2    C N N 560 
THR OXT    O N N 561 
THR H      H N N 562 
THR H2     H N N 563 
THR HA     H N N 564 
THR HB     H N N 565 
THR HG1    H N N 566 
THR HG21   H N N 567 
THR HG22   H N N 568 
THR HG23   H N N 569 
THR HXT    H N N 570 
TRP N      N N N 571 
TRP CA     C N S 572 
TRP C      C N N 573 
TRP O      O N N 574 
TRP CB     C N N 575 
TRP CG     C Y N 576 
TRP CD1    C Y N 577 
TRP CD2    C Y N 578 
TRP NE1    N Y N 579 
TRP CE2    C Y N 580 
TRP CE3    C Y N 581 
TRP CZ2    C Y N 582 
TRP CZ3    C Y N 583 
TRP CH2    C Y N 584 
TRP OXT    O N N 585 
TRP H      H N N 586 
TRP H2     H N N 587 
TRP HA     H N N 588 
TRP HB2    H N N 589 
TRP HB3    H N N 590 
TRP HD1    H N N 591 
TRP HE1    H N N 592 
TRP HE3    H N N 593 
TRP HZ2    H N N 594 
TRP HZ3    H N N 595 
TRP HH2    H N N 596 
TRP HXT    H N N 597 
TYR N      N N N 598 
TYR CA     C N S 599 
TYR C      C N N 600 
TYR O      O N N 601 
TYR CB     C N N 602 
TYR CG     C Y N 603 
TYR CD1    C Y N 604 
TYR CD2    C Y N 605 
TYR CE1    C Y N 606 
TYR CE2    C Y N 607 
TYR CZ     C Y N 608 
TYR OH     O N N 609 
TYR OXT    O N N 610 
TYR H      H N N 611 
TYR H2     H N N 612 
TYR HA     H N N 613 
TYR HB2    H N N 614 
TYR HB3    H N N 615 
TYR HD1    H N N 616 
TYR HD2    H N N 617 
TYR HE1    H N N 618 
TYR HE2    H N N 619 
TYR HH     H N N 620 
TYR HXT    H N N 621 
U   OP3    O N N 622 
U   P      P N N 623 
U   OP1    O N N 624 
U   OP2    O N N 625 
U   "O5'"  O N N 626 
U   "C5'"  C N N 627 
U   "C4'"  C N R 628 
U   "O4'"  O N N 629 
U   "C3'"  C N S 630 
U   "O3'"  O N N 631 
U   "C2'"  C N R 632 
U   "O2'"  O N N 633 
U   "C1'"  C N R 634 
U   N1     N N N 635 
U   C2     C N N 636 
U   O2     O N N 637 
U   N3     N N N 638 
U   C4     C N N 639 
U   O4     O N N 640 
U   C5     C N N 641 
U   C6     C N N 642 
U   HOP3   H N N 643 
U   HOP2   H N N 644 
U   "H5'"  H N N 645 
U   "H5''" H N N 646 
U   "H4'"  H N N 647 
U   "H3'"  H N N 648 
U   "HO3'" H N N 649 
U   "H2'"  H N N 650 
U   "HO2'" H N N 651 
U   "H1'"  H N N 652 
U   H3     H N N 653 
U   H5     H N N 654 
U   H6     H N N 655 
VAL N      N N N 656 
VAL CA     C N S 657 
VAL C      C N N 658 
VAL O      O N N 659 
VAL CB     C N N 660 
VAL CG1    C N N 661 
VAL CG2    C N N 662 
VAL OXT    O N N 663 
VAL H      H N N 664 
VAL H2     H N N 665 
VAL HA     H N N 666 
VAL HB     H N N 667 
VAL HG11   H N N 668 
VAL HG12   H N N 669 
VAL HG13   H N N 670 
VAL HG21   H N N 671 
VAL HG22   H N N 672 
VAL HG23   H N N 673 
VAL HXT    H N N 674 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A   OP3   P      sing N N 1   
A   OP3   HOP3   sing N N 2   
A   P     OP1    doub N N 3   
A   P     OP2    sing N N 4   
A   P     "O5'"  sing N N 5   
A   OP2   HOP2   sing N N 6   
A   "O5'" "C5'"  sing N N 7   
A   "C5'" "C4'"  sing N N 8   
A   "C5'" "H5'"  sing N N 9   
A   "C5'" "H5''" sing N N 10  
A   "C4'" "O4'"  sing N N 11  
A   "C4'" "C3'"  sing N N 12  
A   "C4'" "H4'"  sing N N 13  
A   "O4'" "C1'"  sing N N 14  
A   "C3'" "O3'"  sing N N 15  
A   "C3'" "C2'"  sing N N 16  
A   "C3'" "H3'"  sing N N 17  
A   "O3'" "HO3'" sing N N 18  
A   "C2'" "O2'"  sing N N 19  
A   "C2'" "C1'"  sing N N 20  
A   "C2'" "H2'"  sing N N 21  
A   "O2'" "HO2'" sing N N 22  
A   "C1'" N9     sing N N 23  
A   "C1'" "H1'"  sing N N 24  
A   N9    C8     sing Y N 25  
A   N9    C4     sing Y N 26  
A   C8    N7     doub Y N 27  
A   C8    H8     sing N N 28  
A   N7    C5     sing Y N 29  
A   C5    C6     sing Y N 30  
A   C5    C4     doub Y N 31  
A   C6    N6     sing N N 32  
A   C6    N1     doub Y N 33  
A   N6    H61    sing N N 34  
A   N6    H62    sing N N 35  
A   N1    C2     sing Y N 36  
A   C2    N3     doub Y N 37  
A   C2    H2     sing N N 38  
A   N3    C4     sing Y N 39  
ALA N     CA     sing N N 40  
ALA N     H      sing N N 41  
ALA N     H2     sing N N 42  
ALA CA    C      sing N N 43  
ALA CA    CB     sing N N 44  
ALA CA    HA     sing N N 45  
ALA C     O      doub N N 46  
ALA C     OXT    sing N N 47  
ALA CB    HB1    sing N N 48  
ALA CB    HB2    sing N N 49  
ALA CB    HB3    sing N N 50  
ALA OXT   HXT    sing N N 51  
ARG N     CA     sing N N 52  
ARG N     H      sing N N 53  
ARG N     H2     sing N N 54  
ARG CA    C      sing N N 55  
ARG CA    CB     sing N N 56  
ARG CA    HA     sing N N 57  
ARG C     O      doub N N 58  
ARG C     OXT    sing N N 59  
ARG CB    CG     sing N N 60  
ARG CB    HB2    sing N N 61  
ARG CB    HB3    sing N N 62  
ARG CG    CD     sing N N 63  
ARG CG    HG2    sing N N 64  
ARG CG    HG3    sing N N 65  
ARG CD    NE     sing N N 66  
ARG CD    HD2    sing N N 67  
ARG CD    HD3    sing N N 68  
ARG NE    CZ     sing N N 69  
ARG NE    HE     sing N N 70  
ARG CZ    NH1    sing N N 71  
ARG CZ    NH2    doub N N 72  
ARG NH1   HH11   sing N N 73  
ARG NH1   HH12   sing N N 74  
ARG NH2   HH21   sing N N 75  
ARG NH2   HH22   sing N N 76  
ARG OXT   HXT    sing N N 77  
ASN N     CA     sing N N 78  
ASN N     H      sing N N 79  
ASN N     H2     sing N N 80  
ASN CA    C      sing N N 81  
ASN CA    CB     sing N N 82  
ASN CA    HA     sing N N 83  
ASN C     O      doub N N 84  
ASN C     OXT    sing N N 85  
ASN CB    CG     sing N N 86  
ASN CB    HB2    sing N N 87  
ASN CB    HB3    sing N N 88  
ASN CG    OD1    doub N N 89  
ASN CG    ND2    sing N N 90  
ASN ND2   HD21   sing N N 91  
ASN ND2   HD22   sing N N 92  
ASN OXT   HXT    sing N N 93  
ASP N     CA     sing N N 94  
ASP N     H      sing N N 95  
ASP N     H2     sing N N 96  
ASP CA    C      sing N N 97  
ASP CA    CB     sing N N 98  
ASP CA    HA     sing N N 99  
ASP C     O      doub N N 100 
ASP C     OXT    sing N N 101 
ASP CB    CG     sing N N 102 
ASP CB    HB2    sing N N 103 
ASP CB    HB3    sing N N 104 
ASP CG    OD1    doub N N 105 
ASP CG    OD2    sing N N 106 
ASP OD2   HD2    sing N N 107 
ASP OXT   HXT    sing N N 108 
C   OP3   P      sing N N 109 
C   OP3   HOP3   sing N N 110 
C   P     OP1    doub N N 111 
C   P     OP2    sing N N 112 
C   P     "O5'"  sing N N 113 
C   OP2   HOP2   sing N N 114 
C   "O5'" "C5'"  sing N N 115 
C   "C5'" "C4'"  sing N N 116 
C   "C5'" "H5'"  sing N N 117 
C   "C5'" "H5''" sing N N 118 
C   "C4'" "O4'"  sing N N 119 
C   "C4'" "C3'"  sing N N 120 
C   "C4'" "H4'"  sing N N 121 
C   "O4'" "C1'"  sing N N 122 
C   "C3'" "O3'"  sing N N 123 
C   "C3'" "C2'"  sing N N 124 
C   "C3'" "H3'"  sing N N 125 
C   "O3'" "HO3'" sing N N 126 
C   "C2'" "O2'"  sing N N 127 
C   "C2'" "C1'"  sing N N 128 
C   "C2'" "H2'"  sing N N 129 
C   "O2'" "HO2'" sing N N 130 
C   "C1'" N1     sing N N 131 
C   "C1'" "H1'"  sing N N 132 
C   N1    C2     sing N N 133 
C   N1    C6     sing N N 134 
C   C2    O2     doub N N 135 
C   C2    N3     sing N N 136 
C   N3    C4     doub N N 137 
C   C4    N4     sing N N 138 
C   C4    C5     sing N N 139 
C   N4    H41    sing N N 140 
C   N4    H42    sing N N 141 
C   C5    C6     doub N N 142 
C   C5    H5     sing N N 143 
C   C6    H6     sing N N 144 
CYS N     CA     sing N N 145 
CYS N     H      sing N N 146 
CYS N     H2     sing N N 147 
CYS CA    C      sing N N 148 
CYS CA    CB     sing N N 149 
CYS CA    HA     sing N N 150 
CYS C     O      doub N N 151 
CYS C     OXT    sing N N 152 
CYS CB    SG     sing N N 153 
CYS CB    HB2    sing N N 154 
CYS CB    HB3    sing N N 155 
CYS SG    HG     sing N N 156 
CYS OXT   HXT    sing N N 157 
DA  OP3   P      sing N N 158 
DA  OP3   HOP3   sing N N 159 
DA  P     OP1    doub N N 160 
DA  P     OP2    sing N N 161 
DA  P     "O5'"  sing N N 162 
DA  OP2   HOP2   sing N N 163 
DA  "O5'" "C5'"  sing N N 164 
DA  "C5'" "C4'"  sing N N 165 
DA  "C5'" "H5'"  sing N N 166 
DA  "C5'" "H5''" sing N N 167 
DA  "C4'" "O4'"  sing N N 168 
DA  "C4'" "C3'"  sing N N 169 
DA  "C4'" "H4'"  sing N N 170 
DA  "O4'" "C1'"  sing N N 171 
DA  "C3'" "O3'"  sing N N 172 
DA  "C3'" "C2'"  sing N N 173 
DA  "C3'" "H3'"  sing N N 174 
DA  "O3'" "HO3'" sing N N 175 
DA  "C2'" "C1'"  sing N N 176 
DA  "C2'" "H2'"  sing N N 177 
DA  "C2'" "H2''" sing N N 178 
DA  "C1'" N9     sing N N 179 
DA  "C1'" "H1'"  sing N N 180 
DA  N9    C8     sing Y N 181 
DA  N9    C4     sing Y N 182 
DA  C8    N7     doub Y N 183 
DA  C8    H8     sing N N 184 
DA  N7    C5     sing Y N 185 
DA  C5    C6     sing Y N 186 
DA  C5    C4     doub Y N 187 
DA  C6    N6     sing N N 188 
DA  C6    N1     doub Y N 189 
DA  N6    H61    sing N N 190 
DA  N6    H62    sing N N 191 
DA  N1    C2     sing Y N 192 
DA  C2    N3     doub Y N 193 
DA  C2    H2     sing N N 194 
DA  N3    C4     sing Y N 195 
DC  OP3   P      sing N N 196 
DC  OP3   HOP3   sing N N 197 
DC  P     OP1    doub N N 198 
DC  P     OP2    sing N N 199 
DC  P     "O5'"  sing N N 200 
DC  OP2   HOP2   sing N N 201 
DC  "O5'" "C5'"  sing N N 202 
DC  "C5'" "C4'"  sing N N 203 
DC  "C5'" "H5'"  sing N N 204 
DC  "C5'" "H5''" sing N N 205 
DC  "C4'" "O4'"  sing N N 206 
DC  "C4'" "C3'"  sing N N 207 
DC  "C4'" "H4'"  sing N N 208 
DC  "O4'" "C1'"  sing N N 209 
DC  "C3'" "O3'"  sing N N 210 
DC  "C3'" "C2'"  sing N N 211 
DC  "C3'" "H3'"  sing N N 212 
DC  "O3'" "HO3'" sing N N 213 
DC  "C2'" "C1'"  sing N N 214 
DC  "C2'" "H2'"  sing N N 215 
DC  "C2'" "H2''" sing N N 216 
DC  "C1'" N1     sing N N 217 
DC  "C1'" "H1'"  sing N N 218 
DC  N1    C2     sing N N 219 
DC  N1    C6     sing N N 220 
DC  C2    O2     doub N N 221 
DC  C2    N3     sing N N 222 
DC  N3    C4     doub N N 223 
DC  C4    N4     sing N N 224 
DC  C4    C5     sing N N 225 
DC  N4    H41    sing N N 226 
DC  N4    H42    sing N N 227 
DC  C5    C6     doub N N 228 
DC  C5    H5     sing N N 229 
DC  C6    H6     sing N N 230 
DG  OP3   P      sing N N 231 
DG  OP3   HOP3   sing N N 232 
DG  P     OP1    doub N N 233 
DG  P     OP2    sing N N 234 
DG  P     "O5'"  sing N N 235 
DG  OP2   HOP2   sing N N 236 
DG  "O5'" "C5'"  sing N N 237 
DG  "C5'" "C4'"  sing N N 238 
DG  "C5'" "H5'"  sing N N 239 
DG  "C5'" "H5''" sing N N 240 
DG  "C4'" "O4'"  sing N N 241 
DG  "C4'" "C3'"  sing N N 242 
DG  "C4'" "H4'"  sing N N 243 
DG  "O4'" "C1'"  sing N N 244 
DG  "C3'" "O3'"  sing N N 245 
DG  "C3'" "C2'"  sing N N 246 
DG  "C3'" "H3'"  sing N N 247 
DG  "O3'" "HO3'" sing N N 248 
DG  "C2'" "C1'"  sing N N 249 
DG  "C2'" "H2'"  sing N N 250 
DG  "C2'" "H2''" sing N N 251 
DG  "C1'" N9     sing N N 252 
DG  "C1'" "H1'"  sing N N 253 
DG  N9    C8     sing Y N 254 
DG  N9    C4     sing Y N 255 
DG  C8    N7     doub Y N 256 
DG  C8    H8     sing N N 257 
DG  N7    C5     sing Y N 258 
DG  C5    C6     sing N N 259 
DG  C5    C4     doub Y N 260 
DG  C6    O6     doub N N 261 
DG  C6    N1     sing N N 262 
DG  N1    C2     sing N N 263 
DG  N1    H1     sing N N 264 
DG  C2    N2     sing N N 265 
DG  C2    N3     doub N N 266 
DG  N2    H21    sing N N 267 
DG  N2    H22    sing N N 268 
DG  N3    C4     sing N N 269 
DT  OP3   P      sing N N 270 
DT  OP3   HOP3   sing N N 271 
DT  P     OP1    doub N N 272 
DT  P     OP2    sing N N 273 
DT  P     "O5'"  sing N N 274 
DT  OP2   HOP2   sing N N 275 
DT  "O5'" "C5'"  sing N N 276 
DT  "C5'" "C4'"  sing N N 277 
DT  "C5'" "H5'"  sing N N 278 
DT  "C5'" "H5''" sing N N 279 
DT  "C4'" "O4'"  sing N N 280 
DT  "C4'" "C3'"  sing N N 281 
DT  "C4'" "H4'"  sing N N 282 
DT  "O4'" "C1'"  sing N N 283 
DT  "C3'" "O3'"  sing N N 284 
DT  "C3'" "C2'"  sing N N 285 
DT  "C3'" "H3'"  sing N N 286 
DT  "O3'" "HO3'" sing N N 287 
DT  "C2'" "C1'"  sing N N 288 
DT  "C2'" "H2'"  sing N N 289 
DT  "C2'" "H2''" sing N N 290 
DT  "C1'" N1     sing N N 291 
DT  "C1'" "H1'"  sing N N 292 
DT  N1    C2     sing N N 293 
DT  N1    C6     sing N N 294 
DT  C2    O2     doub N N 295 
DT  C2    N3     sing N N 296 
DT  N3    C4     sing N N 297 
DT  N3    H3     sing N N 298 
DT  C4    O4     doub N N 299 
DT  C4    C5     sing N N 300 
DT  C5    C7     sing N N 301 
DT  C5    C6     doub N N 302 
DT  C7    H71    sing N N 303 
DT  C7    H72    sing N N 304 
DT  C7    H73    sing N N 305 
DT  C6    H6     sing N N 306 
G   OP3   P      sing N N 307 
G   OP3   HOP3   sing N N 308 
G   P     OP1    doub N N 309 
G   P     OP2    sing N N 310 
G   P     "O5'"  sing N N 311 
G   OP2   HOP2   sing N N 312 
G   "O5'" "C5'"  sing N N 313 
G   "C5'" "C4'"  sing N N 314 
G   "C5'" "H5'"  sing N N 315 
G   "C5'" "H5''" sing N N 316 
G   "C4'" "O4'"  sing N N 317 
G   "C4'" "C3'"  sing N N 318 
G   "C4'" "H4'"  sing N N 319 
G   "O4'" "C1'"  sing N N 320 
G   "C3'" "O3'"  sing N N 321 
G   "C3'" "C2'"  sing N N 322 
G   "C3'" "H3'"  sing N N 323 
G   "O3'" "HO3'" sing N N 324 
G   "C2'" "O2'"  sing N N 325 
G   "C2'" "C1'"  sing N N 326 
G   "C2'" "H2'"  sing N N 327 
G   "O2'" "HO2'" sing N N 328 
G   "C1'" N9     sing N N 329 
G   "C1'" "H1'"  sing N N 330 
G   N9    C8     sing Y N 331 
G   N9    C4     sing Y N 332 
G   C8    N7     doub Y N 333 
G   C8    H8     sing N N 334 
G   N7    C5     sing Y N 335 
G   C5    C6     sing N N 336 
G   C5    C4     doub Y N 337 
G   C6    O6     doub N N 338 
G   C6    N1     sing N N 339 
G   N1    C2     sing N N 340 
G   N1    H1     sing N N 341 
G   C2    N2     sing N N 342 
G   C2    N3     doub N N 343 
G   N2    H21    sing N N 344 
G   N2    H22    sing N N 345 
G   N3    C4     sing N N 346 
GLN N     CA     sing N N 347 
GLN N     H      sing N N 348 
GLN N     H2     sing N N 349 
GLN CA    C      sing N N 350 
GLN CA    CB     sing N N 351 
GLN CA    HA     sing N N 352 
GLN C     O      doub N N 353 
GLN C     OXT    sing N N 354 
GLN CB    CG     sing N N 355 
GLN CB    HB2    sing N N 356 
GLN CB    HB3    sing N N 357 
GLN CG    CD     sing N N 358 
GLN CG    HG2    sing N N 359 
GLN CG    HG3    sing N N 360 
GLN CD    OE1    doub N N 361 
GLN CD    NE2    sing N N 362 
GLN NE2   HE21   sing N N 363 
GLN NE2   HE22   sing N N 364 
GLN OXT   HXT    sing N N 365 
GLU N     CA     sing N N 366 
GLU N     H      sing N N 367 
GLU N     H2     sing N N 368 
GLU CA    C      sing N N 369 
GLU CA    CB     sing N N 370 
GLU CA    HA     sing N N 371 
GLU C     O      doub N N 372 
GLU C     OXT    sing N N 373 
GLU CB    CG     sing N N 374 
GLU CB    HB2    sing N N 375 
GLU CB    HB3    sing N N 376 
GLU CG    CD     sing N N 377 
GLU CG    HG2    sing N N 378 
GLU CG    HG3    sing N N 379 
GLU CD    OE1    doub N N 380 
GLU CD    OE2    sing N N 381 
GLU OE2   HE2    sing N N 382 
GLU OXT   HXT    sing N N 383 
GLY N     CA     sing N N 384 
GLY N     H      sing N N 385 
GLY N     H2     sing N N 386 
GLY CA    C      sing N N 387 
GLY CA    HA2    sing N N 388 
GLY CA    HA3    sing N N 389 
GLY C     O      doub N N 390 
GLY C     OXT    sing N N 391 
GLY OXT   HXT    sing N N 392 
HIS N     CA     sing N N 393 
HIS N     H      sing N N 394 
HIS N     H2     sing N N 395 
HIS CA    C      sing N N 396 
HIS CA    CB     sing N N 397 
HIS CA    HA     sing N N 398 
HIS C     O      doub N N 399 
HIS C     OXT    sing N N 400 
HIS CB    CG     sing N N 401 
HIS CB    HB2    sing N N 402 
HIS CB    HB3    sing N N 403 
HIS CG    ND1    sing Y N 404 
HIS CG    CD2    doub Y N 405 
HIS ND1   CE1    doub Y N 406 
HIS ND1   HD1    sing N N 407 
HIS CD2   NE2    sing Y N 408 
HIS CD2   HD2    sing N N 409 
HIS CE1   NE2    sing Y N 410 
HIS CE1   HE1    sing N N 411 
HIS NE2   HE2    sing N N 412 
HIS OXT   HXT    sing N N 413 
ILE N     CA     sing N N 414 
ILE N     H      sing N N 415 
ILE N     H2     sing N N 416 
ILE CA    C      sing N N 417 
ILE CA    CB     sing N N 418 
ILE CA    HA     sing N N 419 
ILE C     O      doub N N 420 
ILE C     OXT    sing N N 421 
ILE CB    CG1    sing N N 422 
ILE CB    CG2    sing N N 423 
ILE CB    HB     sing N N 424 
ILE CG1   CD1    sing N N 425 
ILE CG1   HG12   sing N N 426 
ILE CG1   HG13   sing N N 427 
ILE CG2   HG21   sing N N 428 
ILE CG2   HG22   sing N N 429 
ILE CG2   HG23   sing N N 430 
ILE CD1   HD11   sing N N 431 
ILE CD1   HD12   sing N N 432 
ILE CD1   HD13   sing N N 433 
ILE OXT   HXT    sing N N 434 
LEU N     CA     sing N N 435 
LEU N     H      sing N N 436 
LEU N     H2     sing N N 437 
LEU CA    C      sing N N 438 
LEU CA    CB     sing N N 439 
LEU CA    HA     sing N N 440 
LEU C     O      doub N N 441 
LEU C     OXT    sing N N 442 
LEU CB    CG     sing N N 443 
LEU CB    HB2    sing N N 444 
LEU CB    HB3    sing N N 445 
LEU CG    CD1    sing N N 446 
LEU CG    CD2    sing N N 447 
LEU CG    HG     sing N N 448 
LEU CD1   HD11   sing N N 449 
LEU CD1   HD12   sing N N 450 
LEU CD1   HD13   sing N N 451 
LEU CD2   HD21   sing N N 452 
LEU CD2   HD22   sing N N 453 
LEU CD2   HD23   sing N N 454 
LEU OXT   HXT    sing N N 455 
LYS N     CA     sing N N 456 
LYS N     H      sing N N 457 
LYS N     H2     sing N N 458 
LYS CA    C      sing N N 459 
LYS CA    CB     sing N N 460 
LYS CA    HA     sing N N 461 
LYS C     O      doub N N 462 
LYS C     OXT    sing N N 463 
LYS CB    CG     sing N N 464 
LYS CB    HB2    sing N N 465 
LYS CB    HB3    sing N N 466 
LYS CG    CD     sing N N 467 
LYS CG    HG2    sing N N 468 
LYS CG    HG3    sing N N 469 
LYS CD    CE     sing N N 470 
LYS CD    HD2    sing N N 471 
LYS CD    HD3    sing N N 472 
LYS CE    NZ     sing N N 473 
LYS CE    HE2    sing N N 474 
LYS CE    HE3    sing N N 475 
LYS NZ    HZ1    sing N N 476 
LYS NZ    HZ2    sing N N 477 
LYS NZ    HZ3    sing N N 478 
LYS OXT   HXT    sing N N 479 
MET N     CA     sing N N 480 
MET N     H      sing N N 481 
MET N     H2     sing N N 482 
MET CA    C      sing N N 483 
MET CA    CB     sing N N 484 
MET CA    HA     sing N N 485 
MET C     O      doub N N 486 
MET C     OXT    sing N N 487 
MET CB    CG     sing N N 488 
MET CB    HB2    sing N N 489 
MET CB    HB3    sing N N 490 
MET CG    SD     sing N N 491 
MET CG    HG2    sing N N 492 
MET CG    HG3    sing N N 493 
MET SD    CE     sing N N 494 
MET CE    HE1    sing N N 495 
MET CE    HE2    sing N N 496 
MET CE    HE3    sing N N 497 
MET OXT   HXT    sing N N 498 
PHE N     CA     sing N N 499 
PHE N     H      sing N N 500 
PHE N     H2     sing N N 501 
PHE CA    C      sing N N 502 
PHE CA    CB     sing N N 503 
PHE CA    HA     sing N N 504 
PHE C     O      doub N N 505 
PHE C     OXT    sing N N 506 
PHE CB    CG     sing N N 507 
PHE CB    HB2    sing N N 508 
PHE CB    HB3    sing N N 509 
PHE CG    CD1    doub Y N 510 
PHE CG    CD2    sing Y N 511 
PHE CD1   CE1    sing Y N 512 
PHE CD1   HD1    sing N N 513 
PHE CD2   CE2    doub Y N 514 
PHE CD2   HD2    sing N N 515 
PHE CE1   CZ     doub Y N 516 
PHE CE1   HE1    sing N N 517 
PHE CE2   CZ     sing Y N 518 
PHE CE2   HE2    sing N N 519 
PHE CZ    HZ     sing N N 520 
PHE OXT   HXT    sing N N 521 
PRO N     CA     sing N N 522 
PRO N     CD     sing N N 523 
PRO N     H      sing N N 524 
PRO CA    C      sing N N 525 
PRO CA    CB     sing N N 526 
PRO CA    HA     sing N N 527 
PRO C     O      doub N N 528 
PRO C     OXT    sing N N 529 
PRO CB    CG     sing N N 530 
PRO CB    HB2    sing N N 531 
PRO CB    HB3    sing N N 532 
PRO CG    CD     sing N N 533 
PRO CG    HG2    sing N N 534 
PRO CG    HG3    sing N N 535 
PRO CD    HD2    sing N N 536 
PRO CD    HD3    sing N N 537 
PRO OXT   HXT    sing N N 538 
SER N     CA     sing N N 539 
SER N     H      sing N N 540 
SER N     H2     sing N N 541 
SER CA    C      sing N N 542 
SER CA    CB     sing N N 543 
SER CA    HA     sing N N 544 
SER C     O      doub N N 545 
SER C     OXT    sing N N 546 
SER CB    OG     sing N N 547 
SER CB    HB2    sing N N 548 
SER CB    HB3    sing N N 549 
SER OG    HG     sing N N 550 
SER OXT   HXT    sing N N 551 
THR N     CA     sing N N 552 
THR N     H      sing N N 553 
THR N     H2     sing N N 554 
THR CA    C      sing N N 555 
THR CA    CB     sing N N 556 
THR CA    HA     sing N N 557 
THR C     O      doub N N 558 
THR C     OXT    sing N N 559 
THR CB    OG1    sing N N 560 
THR CB    CG2    sing N N 561 
THR CB    HB     sing N N 562 
THR OG1   HG1    sing N N 563 
THR CG2   HG21   sing N N 564 
THR CG2   HG22   sing N N 565 
THR CG2   HG23   sing N N 566 
THR OXT   HXT    sing N N 567 
TRP N     CA     sing N N 568 
TRP N     H      sing N N 569 
TRP N     H2     sing N N 570 
TRP CA    C      sing N N 571 
TRP CA    CB     sing N N 572 
TRP CA    HA     sing N N 573 
TRP C     O      doub N N 574 
TRP C     OXT    sing N N 575 
TRP CB    CG     sing N N 576 
TRP CB    HB2    sing N N 577 
TRP CB    HB3    sing N N 578 
TRP CG    CD1    doub Y N 579 
TRP CG    CD2    sing Y N 580 
TRP CD1   NE1    sing Y N 581 
TRP CD1   HD1    sing N N 582 
TRP CD2   CE2    doub Y N 583 
TRP CD2   CE3    sing Y N 584 
TRP NE1   CE2    sing Y N 585 
TRP NE1   HE1    sing N N 586 
TRP CE2   CZ2    sing Y N 587 
TRP CE3   CZ3    doub Y N 588 
TRP CE3   HE3    sing N N 589 
TRP CZ2   CH2    doub Y N 590 
TRP CZ2   HZ2    sing N N 591 
TRP CZ3   CH2    sing Y N 592 
TRP CZ3   HZ3    sing N N 593 
TRP CH2   HH2    sing N N 594 
TRP OXT   HXT    sing N N 595 
TYR N     CA     sing N N 596 
TYR N     H      sing N N 597 
TYR N     H2     sing N N 598 
TYR CA    C      sing N N 599 
TYR CA    CB     sing N N 600 
TYR CA    HA     sing N N 601 
TYR C     O      doub N N 602 
TYR C     OXT    sing N N 603 
TYR CB    CG     sing N N 604 
TYR CB    HB2    sing N N 605 
TYR CB    HB3    sing N N 606 
TYR CG    CD1    doub Y N 607 
TYR CG    CD2    sing Y N 608 
TYR CD1   CE1    sing Y N 609 
TYR CD1   HD1    sing N N 610 
TYR CD2   CE2    doub Y N 611 
TYR CD2   HD2    sing N N 612 
TYR CE1   CZ     doub Y N 613 
TYR CE1   HE1    sing N N 614 
TYR CE2   CZ     sing Y N 615 
TYR CE2   HE2    sing N N 616 
TYR CZ    OH     sing N N 617 
TYR OH    HH     sing N N 618 
TYR OXT   HXT    sing N N 619 
U   OP3   P      sing N N 620 
U   OP3   HOP3   sing N N 621 
U   P     OP1    doub N N 622 
U   P     OP2    sing N N 623 
U   P     "O5'"  sing N N 624 
U   OP2   HOP2   sing N N 625 
U   "O5'" "C5'"  sing N N 626 
U   "C5'" "C4'"  sing N N 627 
U   "C5'" "H5'"  sing N N 628 
U   "C5'" "H5''" sing N N 629 
U   "C4'" "O4'"  sing N N 630 
U   "C4'" "C3'"  sing N N 631 
U   "C4'" "H4'"  sing N N 632 
U   "O4'" "C1'"  sing N N 633 
U   "C3'" "O3'"  sing N N 634 
U   "C3'" "C2'"  sing N N 635 
U   "C3'" "H3'"  sing N N 636 
U   "O3'" "HO3'" sing N N 637 
U   "C2'" "O2'"  sing N N 638 
U   "C2'" "C1'"  sing N N 639 
U   "C2'" "H2'"  sing N N 640 
U   "O2'" "HO2'" sing N N 641 
U   "C1'" N1     sing N N 642 
U   "C1'" "H1'"  sing N N 643 
U   N1    C2     sing N N 644 
U   N1    C6     sing N N 645 
U   C2    O2     doub N N 646 
U   C2    N3     sing N N 647 
U   N3    C4     sing N N 648 
U   N3    H3     sing N N 649 
U   C4    O4     doub N N 650 
U   C4    C5     sing N N 651 
U   C5    C6     doub N N 652 
U   C5    H5     sing N N 653 
U   C6    H6     sing N N 654 
VAL N     CA     sing N N 655 
VAL N     H      sing N N 656 
VAL N     H2     sing N N 657 
VAL CA    C      sing N N 658 
VAL CA    CB     sing N N 659 
VAL CA    HA     sing N N 660 
VAL C     O      doub N N 661 
VAL C     OXT    sing N N 662 
VAL CB    CG1    sing N N 663 
VAL CB    CG2    sing N N 664 
VAL CB    HB     sing N N 665 
VAL CG1   HG11   sing N N 666 
VAL CG1   HG12   sing N N 667 
VAL CG1   HG13   sing N N 668 
VAL CG2   HG21   sing N N 669 
VAL CG2   HG22   sing N N 670 
VAL CG2   HG23   sing N N 671 
VAL OXT   HXT    sing N N 672 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-10-16 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8WS6 
_em_admin.last_update        2025-04-16 
_em_admin.map_release_date   2025-04-16 
_em_admin.title              'Cryo-EM mini structure of Cas12-1 with 14 nt complementary heteroduplex' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          12908 
_em_entity_assembly_naturalsource.organism             'unclassified sequences' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          469008 
_em_entity_assembly_recombinant.organism             'Escherichia coli BL21(DE3)' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
8WS6 'double helix'        
8WS6 'a-form double helix' 
8WS6 'b-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B DA 23 1_555 C G  37 1_555 1.316  -5.147 -1.738 -12.565 -33.939 73.045   1  C_DA-10:G11_B C -10 ? B 11 ? 9  3 
1 B DC 24 1_555 C G  35 1_555 -0.008 2.690  0.345  -29.780 -18.660 -89.104  2  C_DC-9:G9_B   C -9  ? B 9  ? ?  ? 
1 C A  33 1_555 B DT 26 1_555 -1.312 -0.240 -0.153 -11.964 -37.856 -12.539  3  B_A7:DT-7_C   B 7   ? C -7 ? 20 1 
1 C U  32 1_555 B DA 27 1_555 0.088  0.227  0.243  -7.108  -15.898 -2.998   4  B_U6:DA-6_C   B 6   ? C -6 ? 20 1 
1 C C  31 1_555 B DG 28 1_555 -0.905 0.226  0.157  -16.058 -11.536 2.599    5  B_C5:DG-5_C   B 5   ? C -5 ? 19 1 
1 C C  30 1_555 B DG 29 1_555 0.002  0.261  0.306  -3.151  -21.173 -1.236   6  B_C4:DG-4_C   B 4   ? C -4 ? 19 1 
1 C C  29 1_555 B DG 30 1_555 0.931  -0.097 -0.147 0.405   -10.124 2.396    7  B_C3:DG-3_C   B 3   ? C -3 ? 19 1 
1 C C  28 1_555 B DG 31 1_555 -0.312 0.615  0.004  2.187   -13.428 11.465   8  B_C2:DG-2_C   B 2   ? C -2 ? ?  1 
1 C U  27 1_555 B DA 32 1_555 -0.427 0.004  0.389  -9.808  8.208   8.542    9  B_U1:DA-1_C   B 1   ? C -1 ? 20 1 
1 B DG 33 1_555 D DC 10 1_555 -0.866 0.412  -2.021 -42.439 -20.435 0.532    10 C_DG0:DC0_D   C 0   ? D 0  ? ?  1 
1 B DA 35 1_555 D DT 8  1_555 0.420  -0.328 0.678  16.363  -26.844 -9.752   11 C_DA2:DT-2_D  C 2   ? D -2 ? 20 1 
1 B DT 36 1_555 D DA 7  1_555 0.572  0.634  0.656  -1.483  -24.875 9.004    12 C_DT3:DA-3_D  C 3   ? D -3 ? ?  ? 
1 B DT 37 1_555 D DA 6  1_555 0.428  -0.283 1.020  -12.072 -9.451  -0.517   13 C_DT4:DA-4_D  C 4   ? D -4 ? 20 1 
1 B DG 38 1_555 D DC 5  1_555 -0.947 0.091  -0.677 -15.570 6.652   12.129   14 C_DG5:DC-5_D  C 5   ? D -5 ? 19 1 
1 B DG 39 1_555 D DC 4  1_555 0.509  -0.183 0.753  19.633  -4.097  0.338    15 C_DG6:DC-6_D  C 6   ? D -6 ? 19 1 
1 C G  10 1_555 C A  25 1_555 -0.053 1.270  0.042  21.682  -12.466 -14.461  16 B_G-16:A-1_B  B -16 ? B -1 ? 8  1 
1 C C  11 1_555 C G  24 1_555 1.181  0.142  -0.191 17.518  -20.615 -1.295   17 B_C-15:G-2_B  B -15 ? B -2 ? 19 1 
1 C U  12 1_555 C A  23 1_555 -0.421 0.411  -0.151 10.646  -20.358 3.747    18 B_U-14:A-3_B  B -14 ? B -3 ? 20 1 
1 C C  13 1_555 C G  22 1_555 -0.506 0.329  -0.111 9.981   -7.049  -5.549   19 B_C-13:G-4_B  B -13 ? B -4 ? 19 1 
1 C G  14 1_555 C C  21 1_555 -0.298 0.227  -0.621 -10.951 -15.189 6.457    20 B_G-12:C-5_B  B -12 ? B -5 ? 19 1 
1 C G  15 1_555 C C  20 1_555 -0.782 0.426  -1.174 -22.909 29.361  7.459    21 B_G-11:C-6_B  B -11 ? B -6 ? ?  1 
1 C U  16 1_555 C G  19 1_555 1.584  -4.187 0.431  -3.918  -0.580  -100.856 22 B_U-10:G-7_B  B -10 ? B -7 ? ?  6 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B DA 23 1_555 C G  37 1_555 B DC 24 1_555 C G  35 1_555 2.860  5.383  0.536  -68.175 129.932 -171.846 -2.705 1.424  0.300  
-65.001 -34.106 -177.668 1  CC_DA-10DC-9:G9G11_BB C -10 ? B 11 ? C -9  ? B 9  ? 
1 B DC 24 1_555 C G  35 1_555 C A  33 1_555 B DT 26 1_555 -1.523 6.958  -1.047 167.405 33.429  -113.468 -3.428 -1.033 -0.805 
-16.863 84.446  -174.908 2  CB_DC-9A7:DT-7G9_CB   C -9  ? B 9  ? B 7   ? C -7 ? 
1 C A  33 1_555 B DT 26 1_555 C U  32 1_555 B DA 27 1_555 -0.050 1.890  -3.263 -1.065  -21.012 -24.683  -6.359 0.061  -1.297 
40.930  -2.074  -32.327  3  BB_A7U6:DA-6DT-7_CC   B 7   ? C -7 ? B 6   ? C -6 ? 
1 C U  32 1_555 B DA 27 1_555 C C  31 1_555 B DG 28 1_555 0.526  0.842  -3.330 -0.590  -3.726  -30.623  -2.308 1.103  -3.197 7.021 
-1.111  -30.849  4  BB_U6C5:DG-5DA-6_CC   B 6   ? C -6 ? B 5   ? C -5 ? 
1 C C  31 1_555 B DG 28 1_555 C C  30 1_555 B DG 29 1_555 -0.848 0.978  -3.531 -5.148  -6.318  -30.689  -3.034 -0.536 -3.362 
11.681  -9.517  -31.728  5  BB_C5C4:DG-4DG-5_CC   B 5   ? C -5 ? B 4   ? C -4 ? 
1 C C  30 1_555 B DG 29 1_555 C C  29 1_555 B DG 30 1_555 0.452  1.895  -3.348 0.898   -8.519  -27.583  -5.588 0.720  -2.669 
17.346  1.828   -28.858  6  BB_C4C3:DG-3DG-4_CC   B 4   ? C -4 ? B 3   ? C -3 ? 
1 C C  29 1_555 B DG 30 1_555 C C  28 1_555 B DG 31 1_555 0.641  1.284  -3.427 2.550   -5.584  -35.951  -2.846 0.662  -3.234 8.966 
4.094   -36.454  7  BB_C3C2:DG-2DG-3_CC   B 3   ? C -3 ? B 2   ? C -2 ? 
1 C C  28 1_555 B DG 31 1_555 C U  27 1_555 B DA 32 1_555 0.179  0.761  -3.248 -1.806  6.278   -31.199  -0.225 0.660  -3.319 
-11.514 -3.312  -31.859  8  BB_C2U1:DA-1DG-2_CC   B 2   ? C -2 ? B 1   ? C -1 ? 
1 B DG 33 1_555 D DC 10 1_555 B DA 35 1_555 D DT 8  1_555 0.012  0.836  4.978  -14.850 1.752   68.666   0.633  -0.817 4.906  1.535 
13.008  70.080   9  CC_DG0DA2:DT-2DC0_DD  C 0   ? D 0  ? C 2   ? D -2 ? 
1 B DA 35 1_555 D DT 8  1_555 B DT 36 1_555 D DA 7  1_555 1.062  -1.037 3.893  7.485   5.609   37.147   -2.428 -0.491 3.837  8.637 
-11.526 38.267   10 CC_DA2DT3:DA-3DT-2_DD C 2   ? D -2 ? C 3   ? D -3 ? 
1 B DT 36 1_555 D DA 7  1_555 B DT 37 1_555 D DA 6  1_555 -0.079 -0.633 3.731  -5.597  -8.814  38.387   0.265  -0.643 3.756  
-13.111 8.326   39.730   11 CC_DT3DT4:DA-4DA-3_DD C 3   ? D -3 ? C 4   ? D -4 ? 
1 B DT 37 1_555 D DA 6  1_555 B DG 38 1_555 D DC 5  1_555 1.209  0.198  3.518  11.504  1.222   30.969   0.112  0.106  3.724  2.195 
-20.662 33.010   12 CC_DT4DG5:DC-5DA-4_DD C 4   ? D -4 ? C 5   ? D -5 ? 
1 B DG 38 1_555 D DC 5  1_555 B DG 39 1_555 D DC 4  1_555 -1.485 0.769  2.753  -4.572  -3.172  39.622   1.436  1.721  2.833  
-4.652  6.705   39.996   13 CC_DG5DG6:DC-6DC-5_DD C 5   ? D -5 ? C 6   ? D -6 ? 
1 C G  10 1_555 C A  25 1_555 C C  11 1_555 C G  24 1_555 0.890  -1.781 3.277  0.527   4.910   40.640   -3.070 -1.216 3.062  7.039 
-0.756  40.926   14 BB_G-16C-15:G-2A-1_BB B -16 ? B -1 ? B -15 ? B -2 ? 
1 C C  11 1_555 C G  24 1_555 C U  12 1_555 C A  23 1_555 -0.932 -2.429 3.555  -4.549  6.489   18.972   -9.677 0.605  2.730  
18.666  13.085  20.546   15 BB_C-15U-14:A-3G-2_BB B -15 ? B -2 ? B -14 ? B -3 ? 
1 C U  12 1_555 C A  23 1_555 C C  13 1_555 C G  22 1_555 -0.657 -1.521 3.244  -3.429  6.611   34.422   -3.460 0.597  2.960  
11.012  5.712   35.195   16 BB_U-14C-13:G-4A-3_BB B -14 ? B -3 ? B -13 ? B -4 ? 
1 C C  13 1_555 C G  22 1_555 C G  14 1_555 C C  21 1_555 1.409  -2.402 4.250  7.382   8.433   28.268   -6.707 -0.832 3.645  
16.471  -14.420 30.366   17 BB_C-13G-12:C-5G-4_BB B -13 ? B -4 ? B -12 ? B -5 ? 
1 C G  14 1_555 C C  21 1_555 C G  15 1_555 C C  20 1_555 0.103  -1.516 3.931  1.306   -6.207  32.698   -1.358 0.092  4.142  
-10.898 -2.294  33.291   18 BB_G-12G-11:C-6C-5_BB B -12 ? B -5 ? B -11 ? B -6 ? 
1 C G  15 1_555 C C  20 1_555 C U  16 1_555 C G  19 1_555 -1.450 -1.074 2.699  7.509   20.288  92.159   -1.026 1.099  2.387  
13.932  -5.156  94.104   19 BB_G-11U-10:G-7C-6_BB B -11 ? B -6 ? B -10 ? B -7 ? 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32188102 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8WS6 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N     . CYS A 1 58  ? 140.726 128.684 125.229 1.00 37.01  ? 58  CYS A N     1 
ATOM 2    C CA    . CYS A 1 58  ? 139.508 129.435 125.511 1.00 37.01  ? 58  CYS A CA    1 
ATOM 3    C C     . CYS A 1 58  ? 138.572 128.655 126.432 1.00 37.01  ? 58  CYS A C     1 
ATOM 4    O O     . CYS A 1 58  ? 137.627 128.018 125.965 1.00 37.01  ? 58  CYS A O     1 
ATOM 5    C CB    . CYS A 1 58  ? 138.789 129.792 124.211 1.00 37.01  ? 58  CYS A CB    1 
ATOM 6    S SG    . CYS A 1 58  ? 139.799 130.711 123.027 1.00 37.01  ? 58  CYS A SG    1 
ATOM 7    N N     . PRO A 1 59  ? 138.836 128.706 127.734 1.00 34.42  ? 59  PRO A N     1 
ATOM 8    C CA    . PRO A 1 59  ? 138.004 127.981 128.698 1.00 34.42  ? 59  PRO A CA    1 
ATOM 9    C C     . PRO A 1 59  ? 136.590 128.529 128.730 1.00 34.42  ? 59  PRO A C     1 
ATOM 10   O O     . PRO A 1 59  ? 136.358 129.700 128.394 1.00 34.42  ? 59  PRO A O     1 
ATOM 11   C CB    . PRO A 1 59  ? 138.727 128.219 130.032 1.00 34.42  ? 59  PRO A CB    1 
ATOM 12   C CG    . PRO A 1 59  ? 140.138 128.511 129.638 1.00 34.42  ? 59  PRO A CG    1 
ATOM 13   C CD    . PRO A 1 59  ? 140.014 129.309 128.378 1.00 34.42  ? 59  PRO A CD    1 
ATOM 14   N N     . PRO A 1 60  ? 135.614 127.710 129.112 1.00 34.04  ? 60  PRO A N     1 
ATOM 15   C CA    . PRO A 1 60  ? 134.219 128.159 129.093 1.00 34.04  ? 60  PRO A CA    1 
ATOM 16   C C     . PRO A 1 60  ? 133.874 129.041 130.283 1.00 34.04  ? 60  PRO A C     1 
ATOM 17   O O     . PRO A 1 60  ? 134.607 129.133 131.270 1.00 34.04  ? 60  PRO A O     1 
ATOM 18   C CB    . PRO A 1 60  ? 133.422 126.849 129.137 1.00 34.04  ? 60  PRO A CB    1 
ATOM 19   C CG    . PRO A 1 60  ? 134.418 125.764 128.822 1.00 34.04  ? 60  PRO A CG    1 
ATOM 20   C CD    . PRO A 1 60  ? 135.714 126.266 129.361 1.00 34.04  ? 60  PRO A CD    1 
ATOM 21   N N     . ALA A 1 61  ? 132.723 129.700 130.166 1.00 33.80  ? 61  ALA A N     1 
ATOM 22   C CA    . ALA A 1 61  ? 132.129 130.477 131.243 1.00 33.80  ? 61  ALA A CA    1 
ATOM 23   C C     . ALA A 1 61  ? 130.622 130.469 131.044 1.00 33.80  ? 61  ALA A C     1 
ATOM 24   O O     . ALA A 1 61  ? 130.142 130.636 129.920 1.00 33.80  ? 61  ALA A O     1 
ATOM 25   C CB    . ALA A 1 61  ? 132.662 131.913 131.272 1.00 33.80  ? 61  ALA A CB    1 
ATOM 26   N N     . LYS A 1 62  ? 129.880 130.266 132.129 1.00 32.32  ? 62  LYS A N     1 
ATOM 27   C CA    . LYS A 1 62  ? 128.442 130.027 132.042 1.00 32.32  ? 62  LYS A CA    1 
ATOM 28   C C     . LYS A 1 62  ? 127.621 131.006 132.880 1.00 32.32  ? 62  LYS A C     1 
ATOM 29   O O     . LYS A 1 62  ? 127.954 131.293 134.029 1.00 32.32  ? 62  LYS A O     1 
ATOM 30   C CB    . LYS A 1 62  ? 128.120 128.588 132.445 1.00 32.32  ? 62  LYS A CB    1 
ATOM 31   C CG    . LYS A 1 62  ? 128.681 127.542 131.496 1.00 32.32  ? 62  LYS A CG    1 
ATOM 32   C CD    . LYS A 1 62  ? 128.510 126.141 132.056 1.00 32.32  ? 62  LYS A CD    1 
ATOM 33   C CE    . LYS A 1 62  ? 129.081 125.101 131.110 1.00 32.32  ? 62  LYS A CE    1 
ATOM 34   N NZ    . LYS A 1 62  ? 130.524 125.337 130.828 1.00 32.32  ? 62  LYS A NZ    1 
ATOM 35   N N     . VAL A 1 63  ? 126.543 131.508 132.283 1.00 32.31  ? 63  VAL A N     1 
ATOM 36   C CA    . VAL A 1 63  ? 125.672 132.500 132.901 1.00 32.31  ? 63  VAL A CA    1 
ATOM 37   C C     . VAL A 1 63  ? 124.236 132.001 132.838 1.00 32.31  ? 63  VAL A C     1 
ATOM 38   O O     . VAL A 1 63  ? 123.885 131.141 132.027 1.00 32.31  ? 63  VAL A O     1 
ATOM 39   C CB    . VAL A 1 63  ? 125.782 133.886 132.228 1.00 32.31  ? 63  VAL A CB    1 
ATOM 40   C CG1   . VAL A 1 63  ? 127.181 134.444 132.383 1.00 32.31  ? 63  VAL A CG1   1 
ATOM 41   C CG2   . VAL A 1 63  ? 125.404 133.794 130.764 1.00 32.31  ? 63  VAL A CG2   1 
ATOM 42   N N     . ASN A 1 64  ? 123.398 132.560 133.706 1.00 35.00  ? 64  ASN A N     1 
ATOM 43   C CA    . ASN A 1 64  ? 122.004 132.160 133.831 1.00 35.00  ? 64  ASN A CA    1 
ATOM 44   C C     . ASN A 1 64  ? 121.094 133.209 133.207 1.00 35.00  ? 64  ASN A C     1 
ATOM 45   O O     . ASN A 1 64  ? 121.299 134.412 133.393 1.00 35.00  ? 64  ASN A O     1 
ATOM 46   C CB    . ASN A 1 64  ? 121.621 131.953 135.299 1.00 35.00  ? 64  ASN A CB    1 
ATOM 47   C CG    . ASN A 1 64  ? 122.332 130.772 135.926 1.00 35.00  ? 64  ASN A CG    1 
ATOM 48   O OD1   . ASN A 1 64  ? 123.240 130.192 135.332 1.00 35.00  ? 64  ASN A OD1   1 
ATOM 49   N ND2   . ASN A 1 64  ? 121.920 130.408 137.134 1.00 35.00  ? 64  ASN A ND2   1 
ATOM 50   N N     . ILE A 1 65  ? 120.090 132.745 132.466 1.00 34.69  ? 65  ILE A N     1 
ATOM 51   C CA    . ILE A 1 65  ? 119.102 133.627 131.854 1.00 34.69  ? 65  ILE A CA    1 
ATOM 52   C C     . ILE A 1 65  ? 118.148 134.123 132.932 1.00 34.69  ? 65  ILE A C     1 
ATOM 53   O O     . ILE A 1 65  ? 117.713 133.351 133.793 1.00 34.69  ? 65  ILE A O     1 
ATOM 54   C CB    . ILE A 1 65  ? 118.344 132.911 130.720 1.00 34.69  ? 65  ILE A CB    1 
ATOM 55   C CG1   . ILE A 1 65  ? 119.287 132.616 129.553 1.00 34.69  ? 65  ILE A CG1   1 
ATOM 56   C CG2   . ILE A 1 65  ? 117.163 133.743 130.247 1.00 34.69  ? 65  ILE A CG2   1 
ATOM 57   C CD1   . ILE A 1 65  ? 118.605 131.983 128.362 1.00 34.69  ? 65  ILE A CD1   1 
ATOM 58   N N     . LEU A 1 66  ? 117.819 135.413 132.895 1.00 34.38  ? 66  LEU A N     1 
ATOM 59   C CA    . LEU A 1 66  ? 116.954 136.006 133.906 1.00 34.38  ? 66  LEU A CA    1 
ATOM 60   C C     . LEU A 1 66  ? 115.627 136.442 133.301 1.00 34.38  ? 66  LEU A C     1 
ATOM 61   O O     . LEU A 1 66  ? 114.599 136.455 133.987 1.00 34.38  ? 66  LEU A O     1 
ATOM 62   C CB    . LEU A 1 66  ? 117.645 137.200 134.568 1.00 34.38  ? 66  LEU A CB    1 
ATOM 63   C CG    . LEU A 1 66  ? 118.961 136.942 135.300 1.00 34.38  ? 66  LEU A CG    1 
ATOM 64   C CD1   . LEU A 1 66  ? 119.444 138.211 135.975 1.00 34.38  ? 66  LEU A CD1   1 
ATOM 65   C CD2   . LEU A 1 66  ? 118.803 135.819 136.311 1.00 34.38  ? 66  LEU A CD2   1 
ATOM 66   N N     . ALA A 1 67  ? 115.638 136.802 132.020 1.00 33.89  ? 67  ALA A N     1 
ATOM 67   C CA    . ALA A 1 67  ? 114.438 137.269 131.346 1.00 33.89  ? 67  ALA A CA    1 
ATOM 68   C C     . ALA A 1 67  ? 114.412 136.706 129.935 1.00 33.89  ? 67  ALA A C     1 
ATOM 69   O O     . ALA A 1 67  ? 115.455 136.387 129.359 1.00 33.89  ? 67  ALA A O     1 
ATOM 70   C CB    . ALA A 1 67  ? 114.364 138.800 131.313 1.00 33.89  ? 67  ALA A CB    1 
ATOM 71   N N     . GLN A 1 68  ? 113.207 136.593 129.384 1.00 33.61  ? 68  GLN A N     1 
ATOM 72   C CA    . GLN A 1 68  ? 113.003 135.921 128.111 1.00 33.61  ? 68  GLN A CA    1 
ATOM 73   C C     . GLN A 1 68  ? 111.682 136.388 127.520 1.00 33.61  ? 68  GLN A C     1 
ATOM 74   O O     . GLN A 1 68  ? 110.619 136.131 128.091 1.00 33.61  ? 68  GLN A O     1 
ATOM 75   C CB    . GLN A 1 68  ? 113.003 134.400 128.304 1.00 33.61  ? 68  GLN A CB    1 
ATOM 76   C CG    . GLN A 1 68  ? 113.273 133.588 127.057 1.00 33.61  ? 68  GLN A CG    1 
ATOM 77   C CD    . GLN A 1 68  ? 113.440 132.112 127.359 1.00 33.61  ? 68  GLN A CD    1 
ATOM 78   O OE1   . GLN A 1 68  ? 113.793 131.322 126.484 1.00 33.61  ? 68  GLN A OE1   1 
ATOM 79   N NE2   . GLN A 1 68  ? 113.185 131.732 128.605 1.00 33.61  ? 68  GLN A NE2   1 
ATOM 80   N N     . SER A 1 69  ? 111.754 137.084 126.382 1.00 32.33  ? 69  SER A N     1 
ATOM 81   C CA    . SER A 1 69  ? 110.536 137.582 125.749 1.00 32.33  ? 69  SER A CA    1 
ATOM 82   C C     . SER A 1 69  ? 109.635 136.437 125.304 1.00 32.33  ? 69  SER A C     1 
ATOM 83   O O     . SER A 1 69  ? 108.452 136.395 125.661 1.00 32.33  ? 69  SER A O     1 
ATOM 84   C CB    . SER A 1 69  ? 110.894 138.476 124.563 1.00 32.33  ? 69  SER A CB    1 
ATOM 85   O OG    . SER A 1 69  ? 111.523 137.729 123.538 1.00 32.33  ? 69  SER A OG    1 
ATOM 86   N N     . ARG A 1 70  ? 110.180 135.501 124.536 1.00 32.92  ? 70  ARG A N     1 
ATOM 87   C CA    . ARG A 1 70  ? 109.536 134.247 124.169 1.00 32.92  ? 70  ARG A CA    1 
ATOM 88   C C     . ARG A 1 70  ? 110.583 133.151 124.311 1.00 32.92  ? 70  ARG A C     1 
ATOM 89   O O     . ARG A 1 70  ? 111.784 133.445 124.269 1.00 32.92  ? 70  ARG A O     1 
ATOM 90   C CB    . ARG A 1 70  ? 108.981 134.294 122.743 1.00 32.92  ? 70  ARG A CB    1 
ATOM 91   C CG    . ARG A 1 70  ? 108.148 135.523 122.416 1.00 32.92  ? 70  ARG A CG    1 
ATOM 92   C CD    . ARG A 1 70  ? 106.808 135.492 123.134 1.00 32.92  ? 70  ARG A CD    1 
ATOM 93   N NE    . ARG A 1 70  ? 105.905 134.497 122.569 1.00 32.92  ? 70  ARG A NE    1 
ATOM 94   C CZ    . ARG A 1 70  ? 104.776 134.101 123.141 1.00 32.92  ? 70  ARG A CZ    1 
ATOM 95   N NH1   . ARG A 1 70  ? 104.378 134.597 124.301 1.00 32.92  ? 70  ARG A NH1   1 
ATOM 96   N NH2   . ARG A 1 70  ? 104.027 133.185 122.533 1.00 32.92  ? 70  ARG A NH2   1 
ATOM 97   N N     . PRO A 1 71  ? 110.187 131.891 124.484 1.00 31.35  ? 71  PRO A N     1 
ATOM 98   C CA    . PRO A 1 71  ? 111.188 130.825 124.628 1.00 31.35  ? 71  PRO A CA    1 
ATOM 99   C C     . PRO A 1 71  ? 112.090 130.710 123.410 1.00 31.35  ? 71  PRO A C     1 
ATOM 100  O O     . PRO A 1 71  ? 111.713 131.123 122.309 1.00 31.35  ? 71  PRO A O     1 
ATOM 101  C CB    . PRO A 1 71  ? 110.330 129.569 124.821 1.00 31.35  ? 71  PRO A CB    1 
ATOM 102  C CG    . PRO A 1 71  ? 109.056 130.085 125.400 1.00 31.35  ? 71  PRO A CG    1 
ATOM 103  C CD    . PRO A 1 71  ? 108.820 131.380 124.682 1.00 31.35  ? 71  PRO A CD    1 
ATOM 104  N N     . LEU A 1 72  ? 113.283 130.150 123.595 1.00 30.87  ? 72  LEU A N     1 
ATOM 105  C CA    . LEU A 1 72  ? 114.285 130.076 122.541 1.00 30.87  ? 72  LEU A CA    1 
ATOM 106  C C     . LEU A 1 72  ? 113.912 129.099 121.432 1.00 30.87  ? 72  LEU A C     1 
ATOM 107  O O     . LEU A 1 72  ? 114.625 129.024 120.426 1.00 30.87  ? 72  LEU A O     1 
ATOM 108  C CB    . LEU A 1 72  ? 115.644 129.692 123.129 1.00 30.87  ? 72  LEU A CB    1 
ATOM 109  C CG    . LEU A 1 72  ? 116.660 130.814 123.338 1.00 30.87  ? 72  LEU A CG    1 
ATOM 110  C CD1   . LEU A 1 72  ? 116.096 131.887 124.246 1.00 30.87  ? 72  LEU A CD1   1 
ATOM 111  C CD2   . LEU A 1 72  ? 117.959 130.264 123.900 1.00 30.87  ? 72  LEU A CD2   1 
ATOM 112  N N     . SER A 1 73  ? 112.821 128.351 121.588 1.00 30.15  ? 73  SER A N     1 
ATOM 113  C CA    . SER A 1 73  ? 112.345 127.456 120.547 1.00 30.15  ? 73  SER A CA    1 
ATOM 114  C C     . SER A 1 73  ? 111.339 128.104 119.609 1.00 30.15  ? 73  SER A C     1 
ATOM 115  O O     . SER A 1 73  ? 110.975 127.488 118.602 1.00 30.15  ? 73  SER A O     1 
ATOM 116  C CB    . SER A 1 73  ? 111.712 126.200 121.165 1.00 30.15  ? 73  SER A CB    1 
ATOM 117  O OG    . SER A 1 73  ? 110.857 126.539 122.242 1.00 30.15  ? 73  SER A OG    1 
ATOM 118  N N     . GLU A 1 74  ? 110.883 129.319 119.905 1.00 30.83  ? 74  GLU A N     1 
ATOM 119  C CA    . GLU A 1 74  ? 109.952 130.052 119.058 1.00 30.83  ? 74  GLU A CA    1 
ATOM 120  C C     . GLU A 1 74  ? 110.678 131.184 118.326 1.00 30.83  ? 74  GLU A C     1 
ATOM 121  O O     . GLU A 1 74  ? 110.059 132.080 117.748 1.00 30.83  ? 74  GLU A O     1 
ATOM 122  C CB    . GLU A 1 74  ? 108.783 130.557 119.911 1.00 30.83  ? 74  GLU A CB    1 
ATOM 123  C CG    . GLU A 1 74  ? 107.706 131.380 119.208 1.00 30.83  ? 74  GLU A CG    1 
ATOM 124  C CD    . GLU A 1 74  ? 106.366 131.307 119.912 1.00 30.83  ? 74  GLU A CD    1 
ATOM 125  O OE1   . GLU A 1 74  ? 105.443 132.046 119.512 1.00 30.83  ? 74  GLU A OE1   1 
ATOM 126  O OE2   . GLU A 1 74  ? 106.236 130.508 120.862 1.00 30.83  ? 74  GLU A OE2   1 
ATOM 127  N N     . TRP A 1 75  ? 112.011 131.126 118.316 1.00 30.39  ? 75  TRP A N     1 
ATOM 128  C CA    . TRP A 1 75  ? 112.866 132.140 117.715 1.00 30.39  ? 75  TRP A CA    1 
ATOM 129  C C     . TRP A 1 75  ? 113.106 131.831 116.249 1.00 30.39  ? 75  TRP A C     1 
ATOM 130  O O     . TRP A 1 75  ? 113.441 130.686 115.912 1.00 30.39  ? 75  TRP A O     1 
ATOM 131  C CB    . TRP A 1 75  ? 114.201 132.212 118.446 1.00 30.39  ? 75  TRP A CB    1 
ATOM 132  C CG    . TRP A 1 75  ? 114.206 133.175 119.579 1.00 30.39  ? 75  TRP A CG    1 
ATOM 133  C CD1   . TRP A 1 75  ? 113.127 133.626 120.278 1.00 30.39  ? 75  TRP A CD1   1 
ATOM 134  C CD2   . TRP A 1 75  ? 115.348 133.819 120.143 1.00 30.39  ? 75  TRP A CD2   1 
ATOM 135  N NE1   . TRP A 1 75  ? 113.528 134.509 121.248 1.00 30.39  ? 75  TRP A NE1   1 
ATOM 136  C CE2   . TRP A 1 75  ? 114.890 134.643 121.186 1.00 30.39  ? 75  TRP A CE2   1 
ATOM 137  C CE3   . TRP A 1 75  ? 116.717 133.775 119.871 1.00 30.39  ? 75  TRP A CE3   1 
ATOM 138  C CZ2   . TRP A 1 75  ? 115.749 135.419 121.951 1.00 30.39  ? 75  TRP A CZ2   1 
ATOM 139  C CZ3   . TRP A 1 75  ? 117.567 134.543 120.635 1.00 30.39  ? 75  TRP A CZ3   1 
ATOM 140  C CH2   . TRP A 1 75  ? 117.082 135.356 121.658 1.00 30.39  ? 75  TRP A CH2   1 
ATOM 141  N N     . PRO A 1 76  ? 112.941 132.809 115.357 1.00 27.43  ? 76  PRO A N     1 
ATOM 142  C CA    . PRO A 1 76  ? 113.236 132.566 113.936 1.00 27.43  ? 76  PRO A CA    1 
ATOM 143  C C     . PRO A 1 76  ? 114.659 132.109 113.675 1.00 27.43  ? 76  PRO A C     1 
ATOM 144  O O     . PRO A 1 76  ? 114.901 131.411 112.682 1.00 27.43  ? 76  PRO A O     1 
ATOM 145  C CB    . PRO A 1 76  ? 112.951 133.928 113.296 1.00 27.43  ? 76  PRO A CB    1 
ATOM 146  C CG    . PRO A 1 76  ? 111.886 134.508 114.156 1.00 27.43  ? 76  PRO A CG    1 
ATOM 147  C CD    . PRO A 1 76  ? 112.243 134.089 115.560 1.00 27.43  ? 76  PRO A CD    1 
ATOM 148  N N     . ILE A 1 77  ? 115.612 132.482 114.530 1.00 28.66  ? 77  ILE A N     1 
ATOM 149  C CA    . ILE A 1 77  ? 116.983 132.005 114.368 1.00 28.66  ? 77  ILE A CA    1 
ATOM 150  C C     . ILE A 1 77  ? 117.053 130.498 114.592 1.00 28.66  ? 77  ILE A C     1 
ATOM 151  O O     . ILE A 1 77  ? 117.840 129.793 113.951 1.00 28.66  ? 77  ILE A O     1 
ATOM 152  C CB    . ILE A 1 77  ? 117.937 132.771 115.306 1.00 28.66  ? 77  ILE A CB    1 
ATOM 153  C CG1   . ILE A 1 77  ? 119.394 132.458 114.963 1.00 28.66  ? 77  ILE A CG1   1 
ATOM 154  C CG2   . ILE A 1 77  ? 117.635 132.476 116.765 1.00 28.66  ? 77  ILE A CG2   1 
ATOM 155  C CD1   . ILE A 1 77  ? 120.387 133.395 115.608 1.00 28.66  ? 77  ILE A CD1   1 
ATOM 156  N N     . ASN A 1 78  ? 116.227 129.982 115.506 1.00 29.82  ? 78  ASN A N     1 
ATOM 157  C CA    . ASN A 1 78  ? 116.231 128.548 115.776 1.00 29.82  ? 78  ASN A CA    1 
ATOM 158  C C     . ASN A 1 78  ? 115.242 127.812 114.881 1.00 29.82  ? 78  ASN A C     1 
ATOM 159  O O     . ASN A 1 78  ? 115.480 126.661 114.500 1.00 29.82  ? 78  ASN A O     1 
ATOM 160  C CB    . ASN A 1 78  ? 115.917 128.291 117.248 1.00 29.82  ? 78  ASN A CB    1 
ATOM 161  C CG    . ASN A 1 78  ? 116.160 126.854 117.650 1.00 29.82  ? 78  ASN A CG    1 
ATOM 162  O OD1   . ASN A 1 78  ? 117.257 126.326 117.472 1.00 29.82  ? 78  ASN A OD1   1 
ATOM 163  N ND2   . ASN A 1 78  ? 115.135 126.210 118.196 1.00 29.82  ? 78  ASN A ND2   1 
ATOM 164  N N     . LEU A 1 79  ? 114.122 128.456 114.543 1.00 28.26  ? 79  LEU A N     1 
ATOM 165  C CA    . LEU A 1 79  ? 113.160 127.837 113.637 1.00 28.26  ? 79  LEU A CA    1 
ATOM 166  C C     . LEU A 1 79  ? 113.768 127.612 112.259 1.00 28.26  ? 79  LEU A C     1 
ATOM 167  O O     . LEU A 1 79  ? 113.566 126.556 111.648 1.00 28.26  ? 79  LEU A O     1 
ATOM 168  C CB    . LEU A 1 79  ? 111.904 128.700 113.534 1.00 28.26  ? 79  LEU A CB    1 
ATOM 169  C CG    . LEU A 1 79  ? 111.007 128.761 114.769 1.00 28.26  ? 79  LEU A CG    1 
ATOM 170  C CD1   . LEU A 1 79  ? 109.736 129.535 114.464 1.00 28.26  ? 79  LEU A CD1   1 
ATOM 171  C CD2   . LEU A 1 79  ? 110.682 127.363 115.262 1.00 28.26  ? 79  LEU A CD2   1 
ATOM 172  N N     . VAL A 1 80  ? 114.509 128.598 111.749 1.00 28.68  ? 80  VAL A N     1 
ATOM 173  C CA    . VAL A 1 80  ? 115.204 128.424 110.477 1.00 28.68  ? 80  VAL A CA    1 
ATOM 174  C C     . VAL A 1 80  ? 116.277 127.351 110.601 1.00 28.68  ? 80  VAL A C     1 
ATOM 175  O O     . VAL A 1 80  ? 116.411 126.484 109.729 1.00 28.68  ? 80  VAL A O     1 
ATOM 176  C CB    . VAL A 1 80  ? 115.793 129.764 109.999 1.00 28.68  ? 80  VAL A CB    1 
ATOM 177  C CG1   . VAL A 1 80  ? 116.838 129.534 108.925 1.00 28.68  ? 80  VAL A CG1   1 
ATOM 178  C CG2   . VAL A 1 80  ? 114.690 130.668 109.479 1.00 28.68  ? 80  VAL A CG2   1 
ATOM 179  N N     . SER A 1 81  ? 117.041 127.378 111.695 1.00 29.84  ? 81  SER A N     1 
ATOM 180  C CA    . SER A 1 81  ? 118.140 126.431 111.860 1.00 29.84  ? 81  SER A CA    1 
ATOM 181  C C     . SER A 1 81  ? 117.638 124.994 111.872 1.00 29.84  ? 81  SER A C     1 
ATOM 182  O O     . SER A 1 81  ? 118.240 124.115 111.246 1.00 29.84  ? 81  SER A O     1 
ATOM 183  C CB    . SER A 1 81  ? 118.909 126.739 113.143 1.00 29.84  ? 81  SER A CB    1 
ATOM 184  O OG    . SER A 1 81  ? 119.938 125.792 113.360 1.00 29.84  ? 81  SER A OG    1 
ATOM 185  N N     . LYS A 1 82  ? 116.536 124.736 112.579 1.00 30.78  ? 82  LYS A N     1 
ATOM 186  C CA    . LYS A 1 82  ? 115.960 123.396 112.587 1.00 30.78  ? 82  LYS A CA    1 
ATOM 187  C C     . LYS A 1 82  ? 115.488 122.991 111.197 1.00 30.78  ? 82  LYS A C     1 
ATOM 188  O O     . LYS A 1 82  ? 115.689 121.846 110.775 1.00 30.78  ? 82  LYS A O     1 
ATOM 189  C CB    . LYS A 1 82  ? 114.806 123.333 113.587 1.00 30.78  ? 82  LYS A CB    1 
ATOM 190  C CG    . LYS A 1 82  ? 114.162 121.963 113.724 1.00 30.78  ? 82  LYS A CG    1 
ATOM 191  C CD    . LYS A 1 82  ? 113.105 121.966 114.817 1.00 30.78  ? 82  LYS A CD    1 
ATOM 192  C CE    . LYS A 1 82  ? 112.350 120.649 114.865 1.00 30.78  ? 82  LYS A CE    1 
ATOM 193  N NZ    . LYS A 1 82  ? 113.229 119.518 115.273 1.00 30.78  ? 82  LYS A NZ    1 
ATOM 194  N N     . GLY A 1 83  ? 114.860 123.918 110.471 1.00 31.01  ? 83  GLY A N     1 
ATOM 195  C CA    . GLY A 1 83  ? 114.377 123.603 109.136 1.00 31.01  ? 83  GLY A CA    1 
ATOM 196  C C     . GLY A 1 83  ? 115.495 123.348 108.142 1.00 31.01  ? 83  GLY A C     1 
ATOM 197  O O     . GLY A 1 83  ? 115.359 122.508 107.249 1.00 31.01  ? 83  GLY A O     1 
ATOM 198  N N     . VAL A 1 84  ? 116.607 124.074 108.274 1.00 30.88  ? 84  VAL A N     1 
ATOM 199  C CA    . VAL A 1 84  ? 117.709 123.915 107.329 1.00 30.88  ? 84  VAL A CA    1 
ATOM 200  C C     . VAL A 1 84  ? 118.294 122.513 107.394 1.00 30.88  ? 84  VAL A C     1 
ATOM 201  O O     . VAL A 1 84  ? 118.466 121.858 106.359 1.00 30.88  ? 84  VAL A O     1 
ATOM 202  C CB    . VAL A 1 84  ? 118.793 124.983 107.577 1.00 30.88  ? 84  VAL A CB    1 
ATOM 203  C CG1   . VAL A 1 84  ? 120.022 124.693 106.737 1.00 30.88  ? 84  VAL A CG1   1 
ATOM 204  C CG2   . VAL A 1 84  ? 118.260 126.360 107.241 1.00 30.88  ? 84  VAL A CG2   1 
ATOM 205  N N     . GLN A 1 85  ? 118.590 122.018 108.594 1.00 32.68  ? 85  GLN A N     1 
ATOM 206  C CA    . GLN A 1 85  ? 119.298 120.750 108.707 1.00 32.68  ? 85  GLN A CA    1 
ATOM 207  C C     . GLN A 1 85  ? 118.387 119.537 108.570 1.00 32.68  ? 85  GLN A C     1 
ATOM 208  O O     . GLN A 1 85  ? 118.858 118.472 108.155 1.00 32.68  ? 85  GLN A O     1 
ATOM 209  C CB    . GLN A 1 85  ? 120.076 120.694 110.025 1.00 32.68  ? 85  GLN A CB    1 
ATOM 210  C CG    . GLN A 1 85  ? 119.332 121.196 111.239 1.00 32.68  ? 85  GLN A CG    1 
ATOM 211  C CD    . GLN A 1 85  ? 120.272 121.525 112.381 1.00 32.68  ? 85  GLN A CD    1 
ATOM 212  O OE1   . GLN A 1 85  ? 121.453 121.188 112.342 1.00 32.68  ? 85  GLN A OE1   1 
ATOM 213  N NE2   . GLN A 1 85  ? 119.756 122.204 113.397 1.00 32.68  ? 85  GLN A NE2   1 
ATOM 214  N N     . GLU A 1 86  ? 117.096 119.665 108.883 1.00 33.57  ? 86  GLU A N     1 
ATOM 215  C CA    . GLU A 1 86  ? 116.174 118.576 108.576 1.00 33.57  ? 86  GLU A CA    1 
ATOM 216  C C     . GLU A 1 86  ? 116.117 118.308 107.079 1.00 33.57  ? 86  GLU A C     1 
ATOM 217  O O     . GLU A 1 86  ? 116.083 117.146 106.658 1.00 33.57  ? 86  GLU A O     1 
ATOM 218  C CB    . GLU A 1 86  ? 114.775 118.886 109.106 1.00 33.57  ? 86  GLU A CB    1 
ATOM 219  C CG    . GLU A 1 86  ? 114.631 118.766 110.609 1.00 33.57  ? 86  GLU A CG    1 
ATOM 220  C CD    . GLU A 1 86  ? 113.223 119.063 111.079 1.00 33.57  ? 86  GLU A CD    1 
ATOM 221  O OE1   . GLU A 1 86  ? 112.412 119.542 110.259 1.00 33.57  ? 86  GLU A OE1   1 
ATOM 222  O OE2   . GLU A 1 86  ? 112.925 118.813 112.266 1.00 33.57  ? 86  GLU A OE2   1 
ATOM 223  N N     . TYR A 1 87  ? 116.098 119.366 106.265 1.00 32.54  ? 87  TYR A N     1 
ATOM 224  C CA    . TYR A 1 87  ? 116.128 119.188 104.819 1.00 32.54  ? 87  TYR A CA    1 
ATOM 225  C C     . TYR A 1 87  ? 117.443 118.564 104.368 1.00 32.54  ? 87  TYR A C     1 
ATOM 226  O O     . TYR A 1 87  ? 117.453 117.665 103.519 1.00 32.54  ? 87  TYR A O     1 
ATOM 227  C CB    . TYR A 1 87  ? 115.892 120.531 104.123 1.00 32.54  ? 87  TYR A CB    1 
ATOM 228  C CG    . TYR A 1 87  ? 116.158 120.525 102.633 1.00 32.54  ? 87  TYR A CG    1 
ATOM 229  C CD1   . TYR A 1 87  ? 117.417 120.826 102.127 1.00 32.54  ? 87  TYR A CD1   1 
ATOM 230  C CD2   . TYR A 1 87  ? 115.151 120.209 101.731 1.00 32.54  ? 87  TYR A CD2   1 
ATOM 231  C CE1   . TYR A 1 87  ? 117.664 120.815 100.768 1.00 32.54  ? 87  TYR A CE1   1 
ATOM 232  C CE2   . TYR A 1 87  ? 115.390 120.197 100.369 1.00 32.54  ? 87  TYR A CE2   1 
ATOM 233  C CZ    . TYR A 1 87  ? 116.650 120.501 99.895  1.00 32.54  ? 87  TYR A CZ    1 
ATOM 234  O OH    . TYR A 1 87  ? 116.894 120.490 98.542  1.00 32.54  ? 87  TYR A OH    1 
ATOM 235  N N     . VAL A 1 88  ? 118.565 119.029 104.925 1.00 33.19  ? 88  VAL A N     1 
ATOM 236  C CA    . VAL A 1 88  ? 119.877 118.544 104.504 1.00 33.19  ? 88  VAL A CA    1 
ATOM 237  C C     . VAL A 1 88  ? 120.134 117.101 104.908 1.00 33.19  ? 88  VAL A C     1 
ATOM 238  O O     . VAL A 1 88  ? 120.650 116.323 104.089 1.00 33.19  ? 88  VAL A O     1 
ATOM 239  C CB    . VAL A 1 88  ? 121.003 119.441 105.058 1.00 33.19  ? 88  VAL A CB    1 
ATOM 240  C CG1   . VAL A 1 88  ? 122.364 118.896 104.667 1.00 33.19  ? 88  VAL A CG1   1 
ATOM 241  C CG2   . VAL A 1 88  ? 120.847 120.858 104.544 1.00 33.19  ? 88  VAL A CG2   1 
ATOM 242  N N     . TYR A 1 89  ? 119.771 116.705 106.125 1.00 35.12  ? 89  TYR A N     1 
ATOM 243  C CA    . TYR A 1 89  ? 120.076 115.372 106.628 1.00 35.12  ? 89  TYR A CA    1 
ATOM 244  C C     . TYR A 1 89  ? 119.278 114.276 105.931 1.00 35.12  ? 89  TYR A C     1 
ATOM 245  O O     . TYR A 1 89  ? 119.399 113.105 106.307 1.00 35.12  ? 89  TYR A O     1 
ATOM 246  C CB    . TYR A 1 89  ? 119.841 115.310 108.139 1.00 35.12  ? 89  TYR A CB    1 
ATOM 247  C CG    . TYR A 1 89  ? 120.854 116.092 108.944 1.00 35.12  ? 89  TYR A CG    1 
ATOM 248  C CD1   . TYR A 1 89  ? 122.201 116.064 108.615 1.00 35.12  ? 89  TYR A CD1   1 
ATOM 249  C CD2   . TYR A 1 89  ? 120.466 116.842 110.046 1.00 35.12  ? 89  TYR A CD2   1 
ATOM 250  C CE1   . TYR A 1 89  ? 123.129 116.775 109.349 1.00 35.12  ? 89  TYR A CE1   1 
ATOM 251  C CE2   . TYR A 1 89  ? 121.386 117.554 110.785 1.00 35.12  ? 89  TYR A CE2   1 
ATOM 252  C CZ    . TYR A 1 89  ? 122.715 117.515 110.434 1.00 35.12  ? 89  TYR A CZ    1 
ATOM 253  O OH    . TYR A 1 89  ? 123.635 118.224 111.172 1.00 35.12  ? 89  TYR A OH    1 
ATOM 254  N N     . GLY A 1 90  ? 118.472 114.623 104.933 1.00 35.22  ? 90  GLY A N     1 
ATOM 255  C CA    . GLY A 1 90  ? 117.775 113.636 104.137 1.00 35.22  ? 90  GLY A CA    1 
ATOM 256  C C     . GLY A 1 90  ? 118.180 113.681 102.678 1.00 35.22  ? 90  GLY A C     1 
ATOM 257  O O     . GLY A 1 90  ? 117.332 113.567 101.788 1.00 35.22  ? 90  GLY A O     1 
ATOM 258  N N     . LEU A 1 91  ? 119.461 113.911 102.431 1.00 33.80  ? 91  LEU A N     1 
ATOM 259  C CA    . LEU A 1 91  ? 119.941 113.967 101.065 1.00 33.80  ? 91  LEU A CA    1 
ATOM 260  C C     . LEU A 1 91  ? 120.706 112.703 100.722 1.00 33.80  ? 91  LEU A C     1 
ATOM 261  O O     . LEU A 1 91  ? 121.168 111.971 101.597 1.00 33.80  ? 91  LEU A O     1 
ATOM 262  C CB    . LEU A 1 91  ? 120.801 115.212 100.819 1.00 33.80  ? 91  LEU A CB    1 
ATOM 263  C CG    . LEU A 1 91  ? 120.069 116.556 100.875 1.00 33.80  ? 91  LEU A CG    1 
ATOM 264  C CD1   . LEU A 1 91  ? 121.009 117.711 100.572 1.00 33.80  ? 91  LEU A CD1   1 
ATOM 265  C CD2   . LEU A 1 91  ? 118.869 116.578 99.941  1.00 33.80  ? 91  LEU A CD2   1 
ATOM 266  N N     . THR A 1 92  ? 120.808 112.453 99.429  1.00 36.30  ? 92  THR A N     1 
ATOM 267  C CA    . THR A 1 92  ? 121.684 111.426 98.880  1.00 36.30  ? 92  THR A CA    1 
ATOM 268  C C     . THR A 1 92  ? 123.042 112.060 98.589  1.00 36.30  ? 92  THR A C     1 
ATOM 269  O O     . THR A 1 92  ? 123.154 113.289 98.559  1.00 36.30  ? 92  THR A O     1 
ATOM 270  C CB    . THR A 1 92  ? 121.040 110.819 97.624  1.00 36.30  ? 92  THR A CB    1 
ATOM 271  O OG1   . THR A 1 92  ? 119.777 110.242 97.974  1.00 36.30  ? 92  THR A OG1   1 
ATOM 272  C CG2   . THR A 1 92  ? 121.901 109.720 97.010  1.00 36.30  ? 92  THR A CG2   1 
ATOM 273  N N     . ALA A 1 93  ? 124.083 111.242 98.438  1.00 36.69  ? 93  ALA A N     1 
ATOM 274  C CA    . ALA A 1 93  ? 125.431 111.717 98.124  1.00 36.69  ? 93  ALA A CA    1 
ATOM 275  C C     . ALA A 1 93  ? 125.511 112.473 96.799  1.00 36.69  ? 93  ALA A C     1 
ATOM 276  O O     . ALA A 1 93  ? 126.552 113.032 96.467  1.00 36.69  ? 93  ALA A O     1 
ATOM 277  C CB    . ALA A 1 93  ? 126.404 110.549 98.105  1.00 36.69  ? 93  ALA A CB    1 
ATOM 278  N N     . ALA A 1 94  ? 124.420 112.470 96.042  1.00 36.11  ? 94  ALA A N     1 
ATOM 279  C CA    . ALA A 1 94  ? 124.359 113.136 94.748  1.00 36.11  ? 94  ALA A CA    1 
ATOM 280  C C     . ALA A 1 94  ? 123.515 114.398 94.786  1.00 36.11  ? 94  ALA A C     1 
ATOM 281  O O     . ALA A 1 94  ? 123.785 115.334 94.029  1.00 36.11  ? 94  ALA A O     1 
ATOM 282  C CB    . ALA A 1 94  ? 123.813 112.174 93.680  1.00 36.11  ? 94  ALA A CB    1 
ATOM 283  N N     . GLU A 1 95  ? 122.499 114.447 95.646  1.00 35.43  ? 95  GLU A N     1 
ATOM 284  C CA    . GLU A 1 95  ? 121.714 115.666 95.791  1.00 35.43  ? 95  GLU A CA    1 
ATOM 285  C C     . GLU A 1 95  ? 122.480 116.723 96.574  1.00 35.43  ? 95  GLU A C     1 
ATOM 286  O O     . GLU A 1 95  ? 122.297 117.925 96.348  1.00 35.43  ? 95  GLU A O     1 
ATOM 287  C CB    . GLU A 1 95  ? 120.382 115.355 96.471  1.00 35.43  ? 95  GLU A CB    1 
ATOM 288  C CG    . GLU A 1 95  ? 119.234 116.242 96.023  1.00 35.43  ? 95  GLU A CG    1 
ATOM 289  C CD    . GLU A 1 95  ? 117.882 115.601 96.254  1.00 35.43  ? 95  GLU A CD    1 
ATOM 290  O OE1   . GLU A 1 95  ? 117.843 114.408 96.620  1.00 35.43  ? 95  GLU A OE1   1 
ATOM 291  O OE2   . GLU A 1 95  ? 116.857 116.291 96.070  1.00 35.43  ? 95  GLU A OE2   1 
ATOM 292  N N     . ARG A 1 96  ? 123.337 116.296 97.503  1.00 34.23  ? 96  ARG A N     1 
ATOM 293  C CA    . ARG A 1 96  ? 124.114 117.251 98.283  1.00 34.23  ? 96  ARG A CA    1 
ATOM 294  C C     . ARG A 1 96  ? 125.079 118.034 97.402  1.00 34.23  ? 96  ARG A C     1 
ATOM 295  O O     . ARG A 1 96  ? 125.253 119.243 97.585  1.00 34.23  ? 96  ARG A O     1 
ATOM 296  C CB    . ARG A 1 96  ? 124.879 116.534 99.392  1.00 34.23  ? 96  ARG A CB    1 
ATOM 297  C CG    . ARG A 1 96  ? 125.594 117.482 100.331 1.00 34.23  ? 96  ARG A CG    1 
ATOM 298  C CD    . ARG A 1 96  ? 126.586 116.753 101.210 1.00 34.23  ? 96  ARG A CD    1 
ATOM 299  N NE    . ARG A 1 96  ? 127.915 116.718 100.613 1.00 34.23  ? 96  ARG A NE    1 
ATOM 300  C CZ    . ARG A 1 96  ? 128.909 117.525 100.958 1.00 34.23  ? 96  ARG A CZ    1 
ATOM 301  N NH1   . ARG A 1 96  ? 128.755 118.452 101.888 1.00 34.23  ? 96  ARG A NH1   1 
ATOM 302  N NH2   . ARG A 1 96  ? 130.086 117.399 100.352 1.00 34.23  ? 96  ARG A NH2   1 
ATOM 303  N N     . GLU A 1 97  ? 125.724 117.360 96.448  1.00 33.77  ? 97  GLU A N     1 
ATOM 304  C CA    . GLU A 1 97  ? 126.671 118.041 95.571  1.00 33.77  ? 97  GLU A CA    1 
ATOM 305  C C     . GLU A 1 97  ? 125.979 119.124 94.756  1.00 33.77  ? 97  GLU A C     1 
ATOM 306  O O     . GLU A 1 97  ? 126.506 120.231 94.596  1.00 33.77  ? 97  GLU A O     1 
ATOM 307  C CB    . GLU A 1 97  ? 127.355 117.030 94.652  1.00 33.77  ? 97  GLU A CB    1 
ATOM 308  C CG    . GLU A 1 97  ? 127.744 115.732 95.336  1.00 33.77  ? 97  GLU A CG    1 
ATOM 309  C CD    . GLU A 1 97  ? 128.898 115.903 96.301  1.00 33.77  ? 97  GLU A CD    1 
ATOM 310  O OE1   . GLU A 1 97  ? 129.947 116.440 95.886  1.00 33.77  ? 97  GLU A OE1   1 
ATOM 311  O OE2   . GLU A 1 97  ? 128.758 115.499 97.473  1.00 33.77  ? 97  GLU A OE2   1 
ATOM 312  N N     . ALA A 1 98  ? 124.793 118.821 94.228  1.00 33.68  ? 98  ALA A N     1 
ATOM 313  C CA    . ALA A 1 98  ? 124.049 119.817 93.465  1.00 33.68  ? 98  ALA A CA    1 
ATOM 314  C C     . ALA A 1 98  ? 123.537 120.933 94.366  1.00 33.68  ? 98  ALA A C     1 
ATOM 315  O O     . ALA A 1 98  ? 123.468 122.094 93.947  1.00 33.68  ? 98  ALA A O     1 
ATOM 316  C CB    . ALA A 1 98  ? 122.893 119.153 92.720  1.00 33.68  ? 98  ALA A CB    1 
ATOM 317  N N     . ASN A 1 99  ? 123.173 120.602 95.603  1.00 33.18  ? 99  ASN A N     1 
ATOM 318  C CA    . ASN A 1 99  ? 122.634 121.568 96.549  1.00 33.18  ? 99  ASN A CA    1 
ATOM 319  C C     . ASN A 1 99  ? 123.671 122.049 97.556  1.00 33.18  ? 99  ASN A C     1 
ATOM 320  O O     . ASN A 1 99  ? 123.306 122.697 98.544  1.00 33.18  ? 99  ASN A O     1 
ATOM 321  C CB    . ASN A 1 99  ? 121.430 120.971 97.277  1.00 33.18  ? 99  ASN A CB    1 
ATOM 322  C CG    . ASN A 1 99  ? 120.280 120.664 96.341  1.00 33.18  ? 99  ASN A CG    1 
ATOM 323  O OD1   . ASN A 1 99  ? 119.914 119.505 96.147  1.00 33.18  ? 99  ASN A OD1   1 
ATOM 324  N ND2   . ASN A 1 99  ? 119.704 121.705 95.751  1.00 33.18  ? 99  ASN A ND2   1 
ATOM 325  N N     . GLY A 1 100 ? 124.947 121.750 97.332  1.00 35.12  ? 100 GLY A N     1 
ATOM 326  C CA    . GLY A 1 100 ? 125.998 122.194 98.225  1.00 35.12  ? 100 GLY A CA    1 
ATOM 327  C C     . GLY A 1 100 ? 126.709 123.436 97.734  1.00 35.12  ? 100 GLY A C     1 
ATOM 328  O O     . GLY A 1 100 ? 127.791 123.776 98.222  1.00 35.12  ? 100 GLY A O     1 
ATOM 329  N N     . ASP A 1 101 ? 126.112 124.119 96.765  1.00 37.65  ? 101 ASP A N     1 
ATOM 330  C CA    . ASP A 1 101 ? 126.643 125.367 96.224  1.00 37.65  ? 101 ASP A CA    1 
ATOM 331  C C     . ASP A 1 101 ? 125.953 126.513 96.958  1.00 37.65  ? 101 ASP A C     1 
ATOM 332  O O     . ASP A 1 101 ? 125.136 127.236 96.385  1.00 37.65  ? 101 ASP A O     1 
ATOM 333  C CB    . ASP A 1 101 ? 126.427 125.452 94.716  1.00 37.65  ? 101 ASP A CB    1 
ATOM 334  C CG    . ASP A 1 101 ? 127.014 124.267 93.975  1.00 37.65  ? 101 ASP A CG    1 
ATOM 335  O OD1   . ASP A 1 101 ? 127.965 123.649 94.499  1.00 37.65  ? 101 ASP A OD1   1 
ATOM 336  O OD2   . ASP A 1 101 ? 126.526 123.954 92.870  1.00 37.65  ? 101 ASP A OD2   1 
ATOM 337  N N     . PHE A 1 102 ? 126.288 126.673 98.234  1.00 33.88  ? 102 PHE A N     1 
ATOM 338  C CA    . PHE A 1 102 ? 125.749 127.742 99.064  1.00 33.88  ? 102 PHE A CA    1 
ATOM 339  C C     . PHE A 1 102 ? 126.848 128.765 99.300  1.00 33.88  ? 102 PHE A C     1 
ATOM 340  O O     . PHE A 1 102 ? 127.942 128.416 99.756  1.00 33.88  ? 102 PHE A O     1 
ATOM 341  C CB    . PHE A 1 102 ? 125.206 127.201 100.395 1.00 33.88  ? 102 PHE A CB    1 
ATOM 342  C CG    . PHE A 1 102 ? 126.258 126.613 101.296 1.00 33.88  ? 102 PHE A CG    1 
ATOM 343  C CD1   . PHE A 1 102 ? 126.733 125.331 101.086 1.00 33.88  ? 102 PHE A CD1   1 
ATOM 344  C CD2   . PHE A 1 102 ? 126.764 127.342 102.359 1.00 33.88  ? 102 PHE A CD2   1 
ATOM 345  C CE1   . PHE A 1 102 ? 127.699 124.790 101.912 1.00 33.88  ? 102 PHE A CE1   1 
ATOM 346  C CE2   . PHE A 1 102 ? 127.732 126.807 103.188 1.00 33.88  ? 102 PHE A CE2   1 
ATOM 347  C CZ    . PHE A 1 102 ? 128.199 125.528 102.963 1.00 33.88  ? 102 PHE A CZ    1 
ATOM 348  N N     . GLY A 1 103 ? 126.571 130.018 98.954  1.00 33.69  ? 103 GLY A N     1 
ATOM 349  C CA    . GLY A 1 103 ? 127.530 131.086 99.113  1.00 33.69  ? 103 GLY A CA    1 
ATOM 350  C C     . GLY A 1 103 ? 127.448 131.725 100.483 1.00 33.69  ? 103 GLY A C     1 
ATOM 351  O O     . GLY A 1 103 ? 126.619 131.374 101.325 1.00 33.69  ? 103 GLY A O     1 
ATOM 352  N N     . THR A 1 104 ? 128.324 132.701 100.705 1.00 33.52  ? 104 THR A N     1 
ATOM 353  C CA    . THR A 1 104 ? 128.324 133.487 101.937 1.00 33.52  ? 104 THR A CA    1 
ATOM 354  C C     . THR A 1 104 ? 127.888 134.925 101.664 1.00 33.52  ? 104 THR A C     1 
ATOM 355  O O     . THR A 1 104 ? 128.408 135.868 102.261 1.00 33.52  ? 104 THR A O     1 
ATOM 356  C CB    . THR A 1 104 ? 129.714 133.501 102.596 1.00 33.52  ? 104 THR A CB    1 
ATOM 357  O OG1   . THR A 1 104 ? 130.692 133.925 101.639 1.00 33.52  ? 104 THR A OG1   1 
ATOM 358  C CG2   . THR A 1 104 ? 130.080 132.115 103.102 1.00 33.52  ? 104 THR A CG2   1 
ATOM 359  N N     . SER A 1 105 ? 126.929 135.078 100.756 1.00 31.55  ? 105 SER A N     1 
ATOM 360  C CA    . SER A 1 105 ? 126.490 136.384 100.293 1.00 31.55  ? 105 SER A CA    1 
ATOM 361  C C     . SER A 1 105 ? 124.974 136.487 100.372 1.00 31.55  ? 105 SER A C     1 
ATOM 362  O O     . SER A 1 105 ? 124.266 135.490 100.528 1.00 31.55  ? 105 SER A O     1 
ATOM 363  C CB    . SER A 1 105 ? 126.959 136.657 98.858  1.00 31.55  ? 105 SER A CB    1 
ATOM 364  O OG    . SER A 1 105 ? 126.340 135.773 97.941  1.00 31.55  ? 105 SER A OG    1 
ATOM 365  N N     . ARG A 1 106 ? 124.482 137.713 100.247 1.00 31.82  ? 106 ARG A N     1 
ATOM 366  C CA    . ARG A 1 106 ? 123.054 137.971 100.309 1.00 31.82  ? 106 ARG A CA    1 
ATOM 367  C C     . ARG A 1 106 ? 122.330 137.289 99.150  1.00 31.82  ? 106 ARG A C     1 
ATOM 368  O O     . ARG A 1 106 ? 121.311 136.629 99.357  1.00 31.82  ? 106 ARG A O     1 
ATOM 369  C CB    . ARG A 1 106 ? 122.786 139.476 100.306 1.00 31.82  ? 106 ARG A CB    1 
ATOM 370  C CG    . ARG A 1 106 ? 121.404 139.859 100.805 1.00 31.82  ? 106 ARG A CG    1 
ATOM 371  C CD    . ARG A 1 106 ? 121.318 141.350 101.072 1.00 31.82  ? 106 ARG A CD    1 
ATOM 372  N NE    . ARG A 1 106 ? 120.053 141.720 101.698 1.00 31.82  ? 106 ARG A NE    1 
ATOM 373  C CZ    . ARG A 1 106 ? 119.756 142.947 102.112 1.00 31.82  ? 106 ARG A CZ    1 
ATOM 374  N NH1   . ARG A 1 106 ? 120.639 143.926 101.973 1.00 31.82  ? 106 ARG A NH1   1 
ATOM 375  N NH2   . ARG A 1 106 ? 118.580 143.194 102.671 1.00 31.82  ? 106 ARG A NH2   1 
ATOM 376  N N     . LYS A 1 107 ? 122.858 137.435 97.936  1.00 30.86  ? 107 LYS A N     1 
ATOM 377  C CA    . LYS A 1 107 ? 122.178 136.886 96.767  1.00 30.86  ? 107 LYS A CA    1 
ATOM 378  C C     . LYS A 1 107 ? 122.220 135.364 96.758  1.00 30.86  ? 107 LYS A C     1 
ATOM 379  O O     . LYS A 1 107 ? 121.228 134.713 96.407  1.00 30.86  ? 107 LYS A O     1 
ATOM 380  C CB    . LYS A 1 107 ? 122.800 137.444 95.488  1.00 30.86  ? 107 LYS A CB    1 
ATOM 381  C CG    . LYS A 1 107 ? 122.229 138.781 95.053  1.00 30.86  ? 107 LYS A CG    1 
ATOM 382  C CD    . LYS A 1 107 ? 120.743 138.674 94.750  1.00 30.86  ? 107 LYS A CD    1 
ATOM 383  C CE    . LYS A 1 107 ? 120.219 139.945 94.102  1.00 30.86  ? 107 LYS A CE    1 
ATOM 384  N NZ    . LYS A 1 107 ? 120.510 141.150 94.927  1.00 30.86  ? 107 LYS A NZ    1 
ATOM 385  N N     . SER A 1 108 ? 123.359 134.778 97.128  1.00 30.21  ? 108 SER A N     1 
ATOM 386  C CA    . SER A 1 108 ? 123.487 133.324 97.106  1.00 30.21  ? 108 SER A CA    1 
ATOM 387  C C     . SER A 1 108 ? 122.535 132.671 98.099  1.00 30.21  ? 108 SER A C     1 
ATOM 388  O O     . SER A 1 108 ? 121.877 131.674 97.782  1.00 30.21  ? 108 SER A O     1 
ATOM 389  C CB    . SER A 1 108 ? 124.931 132.922 97.403  1.00 30.21  ? 108 SER A CB    1 
ATOM 390  O OG    . SER A 1 108 ? 125.286 133.272 98.728  1.00 30.21  ? 108 SER A OG    1 
ATOM 391  N N     . LEU A 1 109 ? 122.450 133.218 99.312  1.00 29.34  ? 109 LEU A N     1 
ATOM 392  C CA    . LEU A 1 109 ? 121.565 132.651 100.319 1.00 29.34  ? 109 LEU A CA    1 
ATOM 393  C C     . LEU A 1 109 ? 120.095 132.840 99.978  1.00 29.34  ? 109 LEU A C     1 
ATOM 394  O O     . LEU A 1 109 ? 119.265 132.053 100.443 1.00 29.34  ? 109 LEU A O     1 
ATOM 395  C CB    . LEU A 1 109 ? 121.866 133.260 101.689 1.00 29.34  ? 109 LEU A CB    1 
ATOM 396  C CG    . LEU A 1 109 ? 123.230 132.917 102.291 1.00 29.34  ? 109 LEU A CG    1 
ATOM 397  C CD1   . LEU A 1 109 ? 123.438 133.653 103.603 1.00 29.34  ? 109 LEU A CD1   1 
ATOM 398  C CD2   . LEU A 1 109 ? 123.386 131.421 102.477 1.00 29.34  ? 109 LEU A CD2   1 
ATOM 399  N N     . ASP A 1 110 ? 119.753 133.851 99.183  1.00 30.29  ? 110 ASP A N     1 
ATOM 400  C CA    . ASP A 1 110 ? 118.403 134.010 98.663  1.00 30.29  ? 110 ASP A CA    1 
ATOM 401  C C     . ASP A 1 110 ? 118.141 133.121 97.457  1.00 30.29  ? 110 ASP A C     1 
ATOM 402  O O     . ASP A 1 110 ? 116.989 132.985 97.038  1.00 30.29  ? 110 ASP A O     1 
ATOM 403  C CB    . ASP A 1 110 ? 118.143 135.474 98.298  1.00 30.29  ? 110 ASP A CB    1 
ATOM 404  C CG    . ASP A 1 110 ? 116.718 135.715 97.841  1.00 30.29  ? 110 ASP A CG    1 
ATOM 405  O OD1   . ASP A 1 110 ? 115.928 134.749 97.826  1.00 30.29  ? 110 ASP A OD1   1 
ATOM 406  O OD2   . ASP A 1 110 ? 116.389 136.870 97.497  1.00 30.29  ? 110 ASP A OD2   1 
ATOM 407  N N     . ARG A 1 111 ? 119.188 132.524 96.888  1.00 29.85  ? 111 ARG A N     1 
ATOM 408  C CA    . ARG A 1 111 ? 119.067 131.487 95.872  1.00 29.85  ? 111 ARG A CA    1 
ATOM 409  C C     . ARG A 1 111 ? 118.905 130.110 96.499  1.00 29.85  ? 111 ARG A C     1 
ATOM 410  O O     . ARG A 1 111 ? 118.077 129.312 96.048  1.00 29.85  ? 111 ARG A O     1 
ATOM 411  C CB    . ARG A 1 111 ? 120.301 131.492 94.968  1.00 29.85  ? 111 ARG A CB    1 
ATOM 412  C CG    . ARG A 1 111 ? 120.067 130.962 93.572  1.00 29.85  ? 111 ARG A CG    1 
ATOM 413  C CD    . ARG A 1 111 ? 121.292 131.185 92.708  1.00 29.85  ? 111 ARG A CD    1 
ATOM 414  N NE    . ARG A 1 111 ? 121.907 132.483 92.958  1.00 29.85  ? 111 ARG A NE    1 
ATOM 415  C CZ    . ARG A 1 111 ? 121.819 133.525 92.143  1.00 29.85  ? 111 ARG A CZ    1 
ATOM 416  N NH1   . ARG A 1 111 ? 121.144 133.459 91.007  1.00 29.85  ? 111 ARG A NH1   1 
ATOM 417  N NH2   . ARG A 1 111 ? 122.423 134.662 92.475  1.00 29.85  ? 111 ARG A NH2   1 
ATOM 418  N N     . TRP A 1 112 ? 119.694 129.827 97.537  1.00 29.56  ? 112 TRP A N     1 
ATOM 419  C CA    . TRP A 1 112 ? 119.632 128.532 98.203  1.00 29.56  ? 112 TRP A CA    1 
ATOM 420  C C     . TRP A 1 112 ? 118.300 128.337 98.916  1.00 29.56  ? 112 TRP A C     1 
ATOM 421  O O     . TRP A 1 112 ? 117.731 127.240 98.889  1.00 29.56  ? 112 TRP A O     1 
ATOM 422  C CB    . TRP A 1 112 ? 120.799 128.407 99.182  1.00 29.56  ? 112 TRP A CB    1 
ATOM 423  C CG    . TRP A 1 112 ? 121.149 127.004 99.560  1.00 29.56  ? 112 TRP A CG    1 
ATOM 424  C CD1   . TRP A 1 112 ? 122.132 126.234 99.019  1.00 29.56  ? 112 TRP A CD1   1 
ATOM 425  C CD2   . TRP A 1 112 ? 120.538 126.215 100.585 1.00 29.56  ? 112 TRP A CD2   1 
ATOM 426  N NE1   . TRP A 1 112 ? 122.163 125.007 99.632  1.00 29.56  ? 112 TRP A NE1   1 
ATOM 427  C CE2   . TRP A 1 112 ? 121.194 124.971 100.600 1.00 29.56  ? 112 TRP A CE2   1 
ATOM 428  C CE3   . TRP A 1 112 ? 119.496 126.438 101.490 1.00 29.56  ? 112 TRP A CE3   1 
ATOM 429  C CZ2   . TRP A 1 112 ? 120.842 123.953 101.480 1.00 29.56  ? 112 TRP A CZ2   1 
ATOM 430  C CZ3   . TRP A 1 112 ? 119.148 125.427 102.362 1.00 29.56  ? 112 TRP A CZ3   1 
ATOM 431  C CH2   . TRP A 1 112 ? 119.819 124.200 102.352 1.00 29.56  ? 112 TRP A CH2   1 
ATOM 432  N N     . PHE A 1 113 ? 117.782 129.386 99.551  1.00 29.22  ? 113 PHE A N     1 
ATOM 433  C CA    . PHE A 1 113 ? 116.540 129.281 100.305 1.00 29.22  ? 113 PHE A CA    1 
ATOM 434  C C     . PHE A 1 113 ? 115.302 129.343 99.423  1.00 29.22  ? 113 PHE A C     1 
ATOM 435  O O     . PHE A 1 113 ? 114.189 129.183 99.935  1.00 29.22  ? 113 PHE A O     1 
ATOM 436  C CB    . PHE A 1 113 ? 116.476 130.376 101.371 1.00 29.22  ? 113 PHE A CB    1 
ATOM 437  C CG    . PHE A 1 113 ? 117.170 130.012 102.651 1.00 29.22  ? 113 PHE A CG    1 
ATOM 438  C CD1   . PHE A 1 113 ? 116.702 128.972 103.433 1.00 29.22  ? 113 PHE A CD1   1 
ATOM 439  C CD2   . PHE A 1 113 ? 118.289 130.707 103.072 1.00 29.22  ? 113 PHE A CD2   1 
ATOM 440  C CE1   . PHE A 1 113 ? 117.338 128.632 104.609 1.00 29.22  ? 113 PHE A CE1   1 
ATOM 441  C CE2   . PHE A 1 113 ? 118.928 130.371 104.247 1.00 29.22  ? 113 PHE A CE2   1 
ATOM 442  C CZ    . PHE A 1 113 ? 118.452 129.333 105.016 1.00 29.22  ? 113 PHE A CZ    1 
ATOM 443  N N     . ALA A 1 114 ? 115.462 129.571 98.124  1.00 29.77  ? 114 ALA A N     1 
ATOM 444  C CA    . ALA A 1 114 ? 114.357 129.498 97.180  1.00 29.77  ? 114 ALA A CA    1 
ATOM 445  C C     . ALA A 1 114 ? 114.434 128.293 96.259  1.00 29.77  ? 114 ALA A C     1 
ATOM 446  O O     . ALA A 1 114 ? 113.391 127.750 95.888  1.00 29.77  ? 114 ALA A O     1 
ATOM 447  C CB    . ALA A 1 114 ? 114.292 130.774 96.327  1.00 29.77  ? 114 ALA A CB    1 
ATOM 448  N N     . ARG A 1 115 ? 115.638 127.864 95.878  1.00 29.34  ? 115 ARG A N     1 
ATOM 449  C CA    . ARG A 1 115 ? 115.777 126.659 95.071  1.00 29.34  ? 115 ARG A CA    1 
ATOM 450  C C     . ARG A 1 115 ? 115.489 125.406 95.890  1.00 29.34  ? 115 ARG A C     1 
ATOM 451  O O     . ARG A 1 115 ? 114.893 124.449 95.381  1.00 29.34  ? 115 ARG A O     1 
ATOM 452  C CB    . ARG A 1 115 ? 117.180 126.598 94.468  1.00 29.34  ? 115 ARG A CB    1 
ATOM 453  C CG    . ARG A 1 115 ? 117.579 125.238 93.933  1.00 29.34  ? 115 ARG A CG    1 
ATOM 454  C CD    . ARG A 1 115 ? 118.969 125.268 93.323  1.00 29.34  ? 115 ARG A CD    1 
ATOM 455  N NE    . ARG A 1 115 ? 120.011 125.394 94.334  1.00 29.34  ? 115 ARG A NE    1 
ATOM 456  C CZ    . ARG A 1 115 ? 121.308 125.456 94.066  1.00 29.34  ? 115 ARG A CZ    1 
ATOM 457  N NH1   . ARG A 1 115 ? 121.760 125.415 92.824  1.00 29.34  ? 115 ARG A NH1   1 
ATOM 458  N NH2   . ARG A 1 115 ? 122.174 125.561 95.070  1.00 29.34  ? 115 ARG A NH2   1 
ATOM 459  N N     . THR A 1 116 ? 115.889 125.396 97.163  1.00 29.27  ? 116 THR A N     1 
ATOM 460  C CA    . THR A 1 116 ? 115.846 124.194 97.986  1.00 29.27  ? 116 THR A CA    1 
ATOM 461  C C     . THR A 1 116 ? 114.639 124.157 98.919  1.00 29.27  ? 116 THR A C     1 
ATOM 462  O O     . THR A 1 116 ? 114.576 123.308 99.814  1.00 29.27  ? 116 THR A O     1 
ATOM 463  C CB    . THR A 1 116 ? 117.137 124.058 98.792  1.00 29.27  ? 116 THR A CB    1 
ATOM 464  O OG1   . THR A 1 116 ? 117.277 125.185 99.665  1.00 29.27  ? 116 THR A OG1   1 
ATOM 465  C CG2   . THR A 1 116 ? 118.336 123.994 97.865  1.00 29.27  ? 116 THR A CG2   1 
ATOM 466  N N     . GLY A 1 117 ? 113.680 125.058 98.735  1.00 27.78  ? 117 GLY A N     1 
ATOM 467  C CA    . GLY A 1 117 ? 112.428 124.962 99.458  1.00 27.78  ? 117 GLY A CA    1 
ATOM 468  C C     . GLY A 1 117 ? 112.444 125.456 100.891 1.00 27.78  ? 117 GLY A C     1 
ATOM 469  O O     . GLY A 1 117 ? 111.458 126.043 101.347 1.00 27.78  ? 117 GLY A O     1 
ATOM 470  N N     . VAL A 1 118 ? 113.539 125.204 101.606 1.00 27.84  ? 118 VAL A N     1 
ATOM 471  C CA    . VAL A 1 118 ? 113.665 125.441 103.047 1.00 27.84  ? 118 VAL A CA    1 
ATOM 472  C C     . VAL A 1 118 ? 113.116 126.809 103.437 1.00 27.84  ? 118 VAL A C     1 
ATOM 473  O O     . VAL A 1 118 ? 113.656 127.841 103.011 1.00 27.84  ? 118 VAL A O     1 
ATOM 474  C CB    . VAL A 1 118 ? 115.126 125.303 103.498 1.00 27.84  ? 118 VAL A CB    1 
ATOM 475  C CG1   . VAL A 1 118 ? 115.223 125.401 105.008 1.00 27.84  ? 118 VAL A CG1   1 
ATOM 476  C CG2   . VAL A 1 118 ? 115.707 123.995 103.005 1.00 27.84  ? 118 VAL A CG2   1 
ATOM 477  N N     . PRO A 1 119 ? 112.052 126.864 104.236 1.00 26.33  ? 119 PRO A N     1 
ATOM 478  C CA    . PRO A 1 119 ? 111.423 128.154 104.541 1.00 26.33  ? 119 PRO A CA    1 
ATOM 479  C C     . PRO A 1 119 ? 112.275 129.011 105.462 1.00 26.33  ? 119 PRO A C     1 
ATOM 480  O O     . PRO A 1 119 ? 113.082 128.507 106.247 1.00 26.33  ? 119 PRO A O     1 
ATOM 481  C CB    . PRO A 1 119 ? 110.110 127.750 105.222 1.00 26.33  ? 119 PRO A CB    1 
ATOM 482  C CG    . PRO A 1 119 ? 109.870 126.345 104.761 1.00 26.33  ? 119 PRO A CG    1 
ATOM 483  C CD    . PRO A 1 119 ? 111.238 125.743 104.726 1.00 26.33  ? 119 PRO A CD    1 
ATOM 484  N N     . THR A 1 120 ? 112.084 130.322 105.354 1.00 29.03  ? 120 THR A N     1 
ATOM 485  C CA    . THR A 1 120 ? 112.634 131.293 106.290 1.00 29.03  ? 120 THR A CA    1 
ATOM 486  C C     . THR A 1 120 ? 111.479 131.988 106.995 1.00 29.03  ? 120 THR A C     1 
ATOM 487  O O     . THR A 1 120 ? 110.565 132.499 106.339 1.00 29.03  ? 120 THR A O     1 
ATOM 488  C CB    . THR A 1 120 ? 113.516 132.320 105.574 1.00 29.03  ? 120 THR A CB    1 
ATOM 489  O OG1   . THR A 1 120 ? 112.785 132.908 104.492 1.00 29.03  ? 120 THR A OG1   1 
ATOM 490  C CG2   . THR A 1 120 ? 114.769 131.657 105.029 1.00 29.03  ? 120 THR A CG2   1 
ATOM 491  N N     . HIS A 1 121 ? 111.519 132.007 108.326 1.00 27.86  ? 121 HIS A N     1 
ATOM 492  C CA    . HIS A 1 121 ? 110.426 132.527 109.135 1.00 27.86  ? 121 HIS A CA    1 
ATOM 493  C C     . HIS A 1 121 ? 110.534 134.028 109.370 1.00 27.86  ? 121 HIS A C     1 
ATOM 494  O O     . HIS A 1 121 ? 109.811 134.573 110.211 1.00 27.86  ? 121 HIS A O     1 
ATOM 495  C CB    . HIS A 1 121 ? 110.364 131.786 110.471 1.00 27.86  ? 121 HIS A CB    1 
ATOM 496  C CG    . HIS A 1 121 ? 109.956 130.352 110.348 1.00 27.86  ? 121 HIS A CG    1 
ATOM 497  N ND1   . HIS A 1 121 ? 110.867 129.318 110.339 1.00 27.86  ? 121 HIS A ND1   1 
ATOM 498  C CD2   . HIS A 1 121 ? 108.735 129.779 110.230 1.00 27.86  ? 121 HIS A CD2   1 
ATOM 499  C CE1   . HIS A 1 121 ? 110.225 128.170 110.220 1.00 27.86  ? 121 HIS A CE1   1 
ATOM 500  N NE2   . HIS A 1 121 ? 108.930 128.422 110.152 1.00 27.86  ? 121 HIS A NE2   1 
ATOM 501  N N     . GLY A 1 122 ? 111.417 134.706 108.645 1.00 28.36  ? 122 GLY A N     1 
ATOM 502  C CA    . GLY A 1 122 ? 111.650 136.120 108.854 1.00 28.36  ? 122 GLY A CA    1 
ATOM 503  C C     . GLY A 1 122 ? 113.118 136.387 109.103 1.00 28.36  ? 122 GLY A C     1 
ATOM 504  O O     . GLY A 1 122 ? 113.515 137.507 109.436 1.00 28.36  ? 122 GLY A O     1 
ATOM 505  N N     . TYR A 1 123 ? 113.931 135.348 108.940 1.00 29.74  ? 123 TYR A N     1 
ATOM 506  C CA    . TYR A 1 123 ? 115.364 135.409 109.197 1.00 29.74  ? 123 TYR A CA    1 
ATOM 507  C C     . TYR A 1 123 ? 116.099 135.553 107.871 1.00 29.74  ? 123 TYR A C     1 
ATOM 508  O O     . TYR A 1 123 ? 116.031 134.665 107.015 1.00 29.74  ? 123 TYR A O     1 
ATOM 509  C CB    . TYR A 1 123 ? 115.824 134.166 109.950 1.00 29.74  ? 123 TYR A CB    1 
ATOM 510  C CG    . TYR A 1 123 ? 117.113 134.355 110.702 1.00 29.74  ? 123 TYR A CG    1 
ATOM 511  C CD1   . TYR A 1 123 ? 117.215 135.284 111.725 1.00 29.74  ? 123 TYR A CD1   1 
ATOM 512  C CD2   . TYR A 1 123 ? 118.231 133.600 110.388 1.00 29.74  ? 123 TYR A CD2   1 
ATOM 513  C CE1   . TYR A 1 123 ? 118.394 135.455 112.410 1.00 29.74  ? 123 TYR A CE1   1 
ATOM 514  C CE2   . TYR A 1 123 ? 119.413 133.764 111.066 1.00 29.74  ? 123 TYR A CE2   1 
ATOM 515  C CZ    . TYR A 1 123 ? 119.489 134.690 112.075 1.00 29.74  ? 123 TYR A CZ    1 
ATOM 516  O OH    . TYR A 1 123 ? 120.670 134.850 112.750 1.00 29.74  ? 123 TYR A OH    1 
ATOM 517  N N     . THR A 1 124 ? 116.777 136.689 107.738 1.00 31.59  ? 124 THR A N     1 
ATOM 518  C CA    . THR A 1 124 ? 117.545 137.054 106.560 1.00 31.59  ? 124 THR A CA    1 
ATOM 519  C C     . THR A 1 124 ? 118.807 137.777 107.017 1.00 31.59  ? 124 THR A C     1 
ATOM 520  O O     . THR A 1 124 ? 119.154 138.834 106.495 1.00 31.59  ? 124 THR A O     1 
ATOM 521  C CB    . THR A 1 124 ? 116.742 137.994 105.640 1.00 31.59  ? 124 THR A CB    1 
ATOM 522  O OG1   . THR A 1 124 ? 115.994 138.919 106.438 1.00 31.59  ? 124 THR A OG1   1 
ATOM 523  C CG2   . THR A 1 124 ? 115.784 137.208 104.754 1.00 31.59  ? 124 THR A CG2   1 
ATOM 524  N N     . THR A 1 125 ? 119.480 137.212 108.012 1.00 33.04  ? 125 THR A N     1 
ATOM 525  C CA    . THR A 1 125 ? 120.712 137.793 108.527 1.00 33.04  ? 125 THR A CA    1 
ATOM 526  C C     . THR A 1 125 ? 121.899 136.978 108.041 1.00 33.04  ? 125 THR A C     1 
ATOM 527  O O     . THR A 1 125 ? 122.010 135.799 108.368 1.00 33.04  ? 125 THR A O     1 
ATOM 528  C CB    . THR A 1 125 ? 120.726 137.803 110.064 1.00 33.04  ? 125 THR A CB    1 
ATOM 529  O OG1   . THR A 1 125 ? 119.625 138.580 110.551 1.00 33.04  ? 125 THR A OG1   1 
ATOM 530  C CG2   . THR A 1 125 ? 122.026 138.393 110.577 1.00 33.04  ? 125 THR A CG2   1 
ATOM 531  N N     . VAL A 1 126 ? 122.784 137.591 107.257 1.00 34.35  ? 126 VAL A N     1 
ATOM 532  C CA    . VAL A 1 126 ? 123.843 136.814 106.620 1.00 34.35  ? 126 VAL A CA    1 
ATOM 533  C C     . VAL A 1 126 ? 124.752 136.180 107.665 1.00 34.35  ? 126 VAL A C     1 
ATOM 534  O O     . VAL A 1 126 ? 125.045 134.979 107.603 1.00 34.35  ? 126 VAL A O     1 
ATOM 535  C CB    . VAL A 1 126 ? 124.633 137.694 105.636 1.00 34.35  ? 126 VAL A CB    1 
ATOM 536  C CG1   . VAL A 1 126 ? 125.702 136.877 104.938 1.00 34.35  ? 126 VAL A CG1   1 
ATOM 537  C CG2   . VAL A 1 126 ? 123.692 138.318 104.622 1.00 34.35  ? 126 VAL A CG2   1 
ATOM 538  N N     . GLN A 1 127 ? 125.203 136.966 108.646 1.00 35.16  ? 127 GLN A N     1 
ATOM 539  C CA    . GLN A 1 127 ? 126.094 136.441 109.675 1.00 35.16  ? 127 GLN A CA    1 
ATOM 540  C C     . GLN A 1 127 ? 125.449 135.344 110.510 1.00 35.16  ? 127 GLN A C     1 
ATOM 541  O O     . GLN A 1 127 ? 126.172 134.554 111.125 1.00 35.16  ? 127 GLN A O     1 
ATOM 542  C CB    . GLN A 1 127 ? 126.566 137.566 110.597 1.00 35.16  ? 127 GLN A CB    1 
ATOM 543  C CG    . GLN A 1 127 ? 127.543 138.533 109.960 1.00 35.16  ? 127 GLN A CG    1 
ATOM 544  C CD    . GLN A 1 127 ? 127.951 139.648 110.901 1.00 35.16  ? 127 GLN A CD    1 
ATOM 545  O OE1   . GLN A 1 127 ? 127.446 139.750 112.018 1.00 35.16  ? 127 GLN A OE1   1 
ATOM 546  N NE2   . GLN A 1 127 ? 128.870 140.493 110.452 1.00 35.16  ? 127 GLN A NE2   1 
ATOM 547  N N     . GLY A 1 128 ? 124.122 135.275 110.545 1.00 33.19  ? 128 GLY A N     1 
ATOM 548  C CA    . GLY A 1 128 ? 123.443 134.239 111.293 1.00 33.19  ? 128 GLY A CA    1 
ATOM 549  C C     . GLY A 1 128 ? 122.968 133.105 110.411 1.00 33.19  ? 128 GLY A C     1 
ATOM 550  O O     . GLY A 1 128 ? 122.271 132.198 110.874 1.00 33.19  ? 128 GLY A O     1 
ATOM 551  N N     . LEU A 1 129 ? 123.343 133.147 109.127 1.00 31.95  ? 129 LEU A N     1 
ATOM 552  C CA    . LEU A 1 129 ? 123.044 132.031 108.236 1.00 31.95  ? 129 LEU A CA    1 
ATOM 553  C C     . LEU A 1 129 ? 124.314 131.349 107.739 1.00 31.95  ? 129 LEU A C     1 
ATOM 554  O O     . LEU A 1 129 ? 124.220 130.326 107.052 1.00 31.95  ? 129 LEU A O     1 
ATOM 555  C CB    . LEU A 1 129 ? 122.198 132.492 107.040 1.00 31.95  ? 129 LEU A CB    1 
ATOM 556  C CG    . LEU A 1 129 ? 120.755 132.906 107.337 1.00 31.95  ? 129 LEU A CG    1 
ATOM 557  C CD1   . LEU A 1 129 ? 120.055 133.360 106.072 1.00 31.95  ? 129 LEU A CD1   1 
ATOM 558  C CD2   . LEU A 1 129 ? 119.997 131.762 107.982 1.00 31.95  ? 129 LEU A CD2   1 
ATOM 559  N N     . ASN A 1 130 ? 125.490 131.884 108.058 1.00 33.71  ? 130 ASN A N     1 
ATOM 560  C CA    . ASN A 1 130 ? 126.740 131.196 107.797 1.00 33.71  ? 130 ASN A CA    1 
ATOM 561  C C     . ASN A 1 130 ? 127.211 130.386 108.995 1.00 33.71  ? 130 ASN A C     1 
ATOM 562  O O     . ASN A 1 130 ? 128.219 129.680 108.888 1.00 33.71  ? 130 ASN A O     1 
ATOM 563  C CB    . ASN A 1 130 ? 127.831 132.193 107.382 1.00 33.71  ? 130 ASN A CB    1 
ATOM 564  C CG    . ASN A 1 130 ? 127.399 133.078 106.233 1.00 33.71  ? 130 ASN A CG    1 
ATOM 565  O OD1   . ASN A 1 130 ? 127.378 134.302 106.349 1.00 33.71  ? 130 ASN A OD1   1 
ATOM 566  N ND2   . ASN A 1 130 ? 127.041 132.460 105.115 1.00 33.71  ? 130 ASN A ND2   1 
ATOM 567  N N     . LEU A 1 131 ? 126.524 130.482 110.131 1.00 33.77  ? 131 LEU A N     1 
ATOM 568  C CA    . LEU A 1 131 ? 126.719 129.574 111.248 1.00 33.77  ? 131 LEU A CA    1 
ATOM 569  C C     . LEU A 1 131 ? 125.715 128.431 111.239 1.00 33.77  ? 131 LEU A C     1 
ATOM 570  O O     . LEU A 1 131 ? 125.848 127.499 112.038 1.00 33.77  ? 131 LEU A O     1 
ATOM 571  C CB    . LEU A 1 131 ? 126.633 130.335 112.575 1.00 33.77  ? 131 LEU A CB    1 
ATOM 572  C CG    . LEU A 1 131 ? 127.693 131.416 112.782 1.00 33.77  ? 131 LEU A CG    1 
ATOM 573  C CD1   . LEU A 1 131 ? 127.462 132.151 114.091 1.00 33.77  ? 131 LEU A CD1   1 
ATOM 574  C CD2   . LEU A 1 131 ? 129.083 130.809 112.742 1.00 33.77  ? 131 LEU A CD2   1 
ATOM 575  N N     . ILE A 1 132 ? 124.712 128.482 110.360 1.00 31.88  ? 132 ILE A N     1 
ATOM 576  C CA    . ILE A 1 132 ? 123.762 127.391 110.196 1.00 31.88  ? 132 ILE A CA    1 
ATOM 577  C C     . ILE A 1 132 ? 124.049 126.560 108.957 1.00 31.88  ? 132 ILE A C     1 
ATOM 578  O O     . ILE A 1 132 ? 123.983 125.325 109.019 1.00 31.88  ? 132 ILE A O     1 
ATOM 579  C CB    . ILE A 1 132 ? 122.313 127.918 110.156 1.00 31.88  ? 132 ILE A CB    1 
ATOM 580  C CG1   . ILE A 1 132 ? 121.984 128.685 111.436 1.00 31.88  ? 132 ILE A CG1   1 
ATOM 581  C CG2   . ILE A 1 132 ? 121.332 126.777 109.959 1.00 31.88  ? 132 ILE A CG2   1 
ATOM 582  C CD1   . ILE A 1 132 ? 120.700 129.469 111.359 1.00 31.88  ? 132 ILE A CD1   1 
ATOM 583  N N     . LEU A 1 133 ? 124.379 127.197 107.833 1.00 31.97  ? 133 LEU A N     1 
ATOM 584  C CA    . LEU A 1 133 ? 124.663 126.482 106.599 1.00 31.97  ? 133 LEU A CA    1 
ATOM 585  C C     . LEU A 1 133 ? 126.103 126.014 106.473 1.00 31.97  ? 133 LEU A C     1 
ATOM 586  O O     . LEU A 1 133 ? 126.395 125.224 105.570 1.00 31.97  ? 133 LEU A O     1 
ATOM 587  C CB    . LEU A 1 133 ? 124.309 127.341 105.375 1.00 31.97  ? 133 LEU A CB    1 
ATOM 588  C CG    . LEU A 1 133 ? 122.835 127.432 104.967 1.00 31.97  ? 133 LEU A CG    1 
ATOM 589  C CD1   . LEU A 1 133 ? 122.016 128.266 105.938 1.00 31.97  ? 133 LEU A CD1   1 
ATOM 590  C CD2   . LEU A 1 133 ? 122.709 127.973 103.552 1.00 31.97  ? 133 LEU A CD2   1 
ATOM 591  N N     . ARG A 1 134 ? 127.012 126.473 107.330 1.00 33.55  ? 134 ARG A N     1 
ATOM 592  C CA    . ARG A 1 134 ? 128.345 125.896 107.382 1.00 33.55  ? 134 ARG A CA    1 
ATOM 593  C C     . ARG A 1 134 ? 128.447 124.767 108.391 1.00 33.55  ? 134 ARG A C     1 
ATOM 594  O O     . ARG A 1 134 ? 129.181 123.807 108.145 1.00 33.55  ? 134 ARG A O     1 
ATOM 595  C CB    . ARG A 1 134 ? 129.389 126.981 107.701 1.00 33.55  ? 134 ARG A CB    1 
ATOM 596  C CG    . ARG A 1 134 ? 130.860 126.543 107.648 1.00 33.55  ? 134 ARG A CG    1 
ATOM 597  C CD    . ARG A 1 134 ? 131.373 125.950 108.956 1.00 33.55  ? 134 ARG A CD    1 
ATOM 598  N NE    . ARG A 1 134 ? 131.203 126.869 110.074 1.00 33.55  ? 134 ARG A NE    1 
ATOM 599  C CZ    . ARG A 1 134 ? 132.035 127.861 110.361 1.00 33.55  ? 134 ARG A CZ    1 
ATOM 600  N NH1   . ARG A 1 134 ? 133.115 128.089 109.632 1.00 33.55  ? 134 ARG A NH1   1 
ATOM 601  N NH2   . ARG A 1 134 ? 131.778 128.642 111.406 1.00 33.55  ? 134 ARG A NH2   1 
ATOM 602  N N     . HIS A 1 135 ? 127.717 124.851 109.503 1.00 33.10  ? 135 HIS A N     1 
ATOM 603  C CA    . HIS A 1 135 ? 127.745 123.784 110.495 1.00 33.10  ? 135 HIS A CA    1 
ATOM 604  C C     . HIS A 1 135 ? 127.023 122.542 109.988 1.00 33.10  ? 135 HIS A C     1 
ATOM 605  O O     . HIS A 1 135 ? 127.494 121.417 110.185 1.00 33.10  ? 135 HIS A O     1 
ATOM 606  C CB    . HIS A 1 135 ? 127.123 124.275 111.801 1.00 33.10  ? 135 HIS A CB    1 
ATOM 607  C CG    . HIS A 1 135 ? 127.926 125.334 112.489 1.00 33.10  ? 135 HIS A CG    1 
ATOM 608  N ND1   . HIS A 1 135 ? 129.150 125.761 112.023 1.00 33.10  ? 135 HIS A ND1   1 
ATOM 609  C CD2   . HIS A 1 135 ? 127.677 126.055 113.607 1.00 33.10  ? 135 HIS A CD2   1 
ATOM 610  C CE1   . HIS A 1 135 ? 129.623 126.697 112.827 1.00 33.10  ? 135 HIS A CE1   1 
ATOM 611  N NE2   . HIS A 1 135 ? 128.747 126.894 113.796 1.00 33.10  ? 135 HIS A NE2   1 
ATOM 612  N N     . THR A 1 136 ? 125.885 122.729 109.315 1.00 32.40  ? 136 THR A N     1 
ATOM 613  C CA    . THR A 1 136 ? 125.064 121.592 108.907 1.00 32.40  ? 136 THR A CA    1 
ATOM 614  C C     . THR A 1 136 ? 125.800 120.698 107.917 1.00 32.40  ? 136 THR A C     1 
ATOM 615  O O     . THR A 1 136 ? 125.875 119.479 108.104 1.00 32.40  ? 136 THR A O     1 
ATOM 616  C CB    . THR A 1 136 ? 123.749 122.085 108.307 1.00 32.40  ? 136 THR A CB    1 
ATOM 617  O OG1   . THR A 1 136 ? 123.014 122.813 109.298 1.00 32.40  ? 136 THR A OG1   1 
ATOM 618  C CG2   . THR A 1 136 ? 122.917 120.915 107.828 1.00 32.40  ? 136 THR A CG2   1 
ATOM 619  N N     . PHE A 1 137 ? 126.355 121.286 106.856 1.00 32.78  ? 137 PHE A N     1 
ATOM 620  C CA    . PHE A 1 137 ? 127.049 120.484 105.854 1.00 32.78  ? 137 PHE A CA    1 
ATOM 621  C C     . PHE A 1 137 ? 128.381 119.960 106.376 1.00 32.78  ? 137 PHE A C     1 
ATOM 622  O O     . PHE A 1 137 ? 128.871 118.926 105.909 1.00 32.78  ? 137 PHE A O     1 
ATOM 623  C CB    . PHE A 1 137 ? 127.242 121.292 104.572 1.00 32.78  ? 137 PHE A CB    1 
ATOM 624  C CG    . PHE A 1 137 ? 125.954 121.693 103.912 1.00 32.78  ? 137 PHE A CG    1 
ATOM 625  C CD1   . PHE A 1 137 ? 125.249 122.800 104.341 1.00 32.78  ? 137 PHE A CD1   1 
ATOM 626  C CD2   . PHE A 1 137 ? 125.450 120.956 102.857 1.00 32.78  ? 137 PHE A CD2   1 
ATOM 627  C CE1   . PHE A 1 137 ? 124.065 123.164 103.736 1.00 32.78  ? 137 PHE A CE1   1 
ATOM 628  C CE2   . PHE A 1 137 ? 124.268 121.315 102.247 1.00 32.78  ? 137 PHE A CE2   1 
ATOM 629  C CZ    . PHE A 1 137 ? 123.575 122.419 102.687 1.00 32.78  ? 137 PHE A CZ    1 
ATOM 630  N N     . ASN A 1 138 ? 128.985 120.653 107.343 1.00 33.85  ? 138 ASN A N     1 
ATOM 631  C CA    . ASN A 1 138 ? 130.247 120.169 107.891 1.00 33.85  ? 138 ASN A CA    1 
ATOM 632  C C     . ASN A 1 138 ? 130.021 118.981 108.819 1.00 33.85  ? 138 ASN A C     1 
ATOM 633  O O     . ASN A 1 138 ? 130.869 118.086 108.906 1.00 33.85  ? 138 ASN A O     1 
ATOM 634  C CB    . ASN A 1 138 ? 130.979 121.300 108.611 1.00 33.85  ? 138 ASN A CB    1 
ATOM 635  C CG    . ASN A 1 138 ? 132.477 121.090 108.648 1.00 33.85  ? 138 ASN A CG    1 
ATOM 636  O OD1   . ASN A 1 138 ? 132.980 120.047 108.229 1.00 33.85  ? 138 ASN A OD1   1 
ATOM 637  N ND2   . ASN A 1 138 ? 133.203 122.088 109.135 1.00 33.85  ? 138 ASN A ND2   1 
ATOM 638  N N     . ARG A 1 139 ? 128.882 118.951 109.519 1.00 34.20  ? 139 ARG A N     1 
ATOM 639  C CA    . ARG A 1 139 ? 128.506 117.746 110.253 1.00 34.20  ? 139 ARG A CA    1 
ATOM 640  C C     . ARG A 1 139 ? 128.070 116.642 109.300 1.00 34.20  ? 139 ARG A C     1 
ATOM 641  O O     . ARG A 1 139 ? 128.228 115.453 109.600 1.00 34.20  ? 139 ARG A O     1 
ATOM 642  C CB    . ARG A 1 139 ? 127.394 118.051 111.256 1.00 34.20  ? 139 ARG A CB    1 
ATOM 643  C CG    . ARG A 1 139 ? 127.709 119.166 112.233 1.00 34.20  ? 139 ARG A CG    1 
ATOM 644  C CD    . ARG A 1 139 ? 126.979 118.964 113.551 1.00 34.20  ? 139 ARG A CD    1 
ATOM 645  N NE    . ARG A 1 139 ? 125.543 119.180 113.417 1.00 34.20  ? 139 ARG A NE    1 
ATOM 646  C CZ    . ARG A 1 139 ? 124.962 120.372 113.387 1.00 34.20  ? 139 ARG A CZ    1 
ATOM 647  N NH1   . ARG A 1 139 ? 125.665 121.487 113.486 1.00 34.20  ? 139 ARG A NH1   1 
ATOM 648  N NH2   . ARG A 1 139 ? 123.641 120.445 113.257 1.00 34.20  ? 139 ARG A NH2   1 
ATOM 649  N N     . TYR A 1 140 ? 127.519 117.019 108.152 1.00 35.54  ? 140 TYR A N     1 
ATOM 650  C CA    . TYR A 1 140 ? 127.114 116.013 107.181 1.00 35.54  ? 140 TYR A CA    1 
ATOM 651  C C     . TYR A 1 140 ? 128.338 115.218 106.744 1.00 35.54  ? 140 TYR A C     1 
ATOM 652  O O     . TYR A 1 140 ? 128.334 113.989 106.811 1.00 35.54  ? 140 TYR A O     1 
ATOM 653  C CB    . TYR A 1 140 ? 126.404 116.632 105.977 1.00 35.54  ? 140 TYR A CB    1 
ATOM 654  C CG    . TYR A 1 140 ? 125.571 115.637 105.201 1.00 35.54  ? 140 TYR A CG    1 
ATOM 655  C CD1   . TYR A 1 140 ? 126.139 114.846 104.211 1.00 35.54  ? 140 TYR A CD1   1 
ATOM 656  C CD2   . TYR A 1 140 ? 124.218 115.482 105.465 1.00 35.54  ? 140 TYR A CD2   1 
ATOM 657  C CE1   . TYR A 1 140 ? 125.382 113.932 103.505 1.00 35.54  ? 140 TYR A CE1   1 
ATOM 658  C CE2   . TYR A 1 140 ? 123.453 114.571 104.762 1.00 35.54  ? 140 TYR A CE2   1 
ATOM 659  C CZ    . TYR A 1 140 ? 124.041 113.800 103.783 1.00 35.54  ? 140 TYR A CZ    1 
ATOM 660  O OH    . TYR A 1 140 ? 123.289 112.892 103.081 1.00 35.54  ? 140 TYR A OH    1 
ATOM 661  N N     . ASP A 1 141 ? 129.389 115.912 106.310 1.00 37.96  ? 141 ASP A N     1 
ATOM 662  C CA    . ASP A 1 141 ? 130.600 115.216 105.893 1.00 37.96  ? 141 ASP A CA    1 
ATOM 663  C C     . ASP A 1 141 ? 131.270 114.492 107.051 1.00 37.96  ? 141 ASP A C     1 
ATOM 664  O O     . ASP A 1 141 ? 132.111 113.616 106.819 1.00 37.96  ? 141 ASP A O     1 
ATOM 665  C CB    . ASP A 1 141 ? 131.582 116.202 105.255 1.00 37.96  ? 141 ASP A CB    1 
ATOM 666  C CG    . ASP A 1 141 ? 131.340 116.389 103.770 1.00 37.96  ? 141 ASP A CG    1 
ATOM 667  O OD1   . ASP A 1 141 ? 131.334 115.379 103.035 1.00 37.96  ? 141 ASP A OD1   1 
ATOM 668  O OD2   . ASP A 1 141 ? 131.156 117.545 103.336 1.00 37.96  ? 141 ASP A OD2   1 
ATOM 669  N N     . GLY A 1 142 ? 130.921 114.840 108.290 1.00 40.86  ? 142 GLY A N     1 
ATOM 670  C CA    . GLY A 1 142 ? 131.514 114.166 109.433 1.00 40.86  ? 142 GLY A CA    1 
ATOM 671  C C     . GLY A 1 142 ? 131.166 112.692 109.489 1.00 40.86  ? 142 GLY A C     1 
ATOM 672  O O     . GLY A 1 142 ? 132.006 111.862 109.848 1.00 40.86  ? 142 GLY A O     1 
ATOM 673  N N     . VAL A 1 143 ? 129.925 112.345 109.142 1.00 41.53  ? 143 VAL A N     1 
ATOM 674  C CA    . VAL A 1 143 ? 129.518 110.943 109.152 1.00 41.53  ? 143 VAL A CA    1 
ATOM 675  C C     . VAL A 1 143 ? 130.301 110.150 108.113 1.00 41.53  ? 143 VAL A C     1 
ATOM 676  O O     . VAL A 1 143 ? 130.782 109.044 108.389 1.00 41.53  ? 143 VAL A O     1 
ATOM 677  C CB    . VAL A 1 143 ? 128.001 110.820 108.931 1.00 41.53  ? 143 VAL A CB    1 
ATOM 678  C CG1   . VAL A 1 143 ? 127.578 109.366 109.033 1.00 41.53  ? 143 VAL A CG1   1 
ATOM 679  C CG2   . VAL A 1 143 ? 127.251 111.669 109.936 1.00 41.53  ? 143 VAL A CG2   1 
ATOM 680  N N     . ILE A 1 144 ? 130.437 110.694 106.901 1.00 44.86  ? 144 ILE A N     1 
ATOM 681  C CA    . ILE A 1 144 ? 131.223 110.017 105.874 1.00 44.86  ? 144 ILE A CA    1 
ATOM 682  C C     . ILE A 1 144 ? 132.689 109.957 106.281 1.00 44.86  ? 144 ILE A C     1 
ATOM 683  O O     . ILE A 1 144 ? 133.357 108.932 106.096 1.00 44.86  ? 144 ILE A O     1 
ATOM 684  C CB    . ILE A 1 144 ? 131.044 110.702 104.508 1.00 44.86  ? 144 ILE A CB    1 
ATOM 685  C CG1   . ILE A 1 144 ? 129.583 110.642 104.059 1.00 44.86  ? 144 ILE A CG1   1 
ATOM 686  C CG2   . ILE A 1 144 ? 131.933 110.046 103.465 1.00 44.86  ? 144 ILE A CG2   1 
ATOM 687  C CD1   . ILE A 1 144 ? 128.817 111.919 104.281 1.00 44.86  ? 144 ILE A CD1   1 
ATOM 688  N N     . LYS A 1 145 ? 133.214 111.051 106.839 1.00 46.54  ? 145 LYS A N     1 
ATOM 689  C CA    . LYS A 1 145 ? 134.590 111.043 107.324 1.00 46.54  ? 145 LYS A CA    1 
ATOM 690  C C     . LYS A 1 145 ? 134.768 110.034 108.450 1.00 46.54  ? 145 LYS A C     1 
ATOM 691  O O     . LYS A 1 145 ? 135.775 109.320 108.496 1.00 46.54  ? 145 LYS A O     1 
ATOM 692  C CB    . LYS A 1 145 ? 134.992 112.444 107.786 1.00 46.54  ? 145 LYS A CB    1 
ATOM 693  C CG    . LYS A 1 145 ? 136.437 112.557 108.244 1.00 46.54  ? 145 LYS A CG    1 
ATOM 694  C CD    . LYS A 1 145 ? 136.919 113.997 108.193 1.00 46.54  ? 145 LYS A CD    1 
ATOM 695  C CE    . LYS A 1 145 ? 138.429 114.082 108.336 1.00 46.54  ? 145 LYS A CE    1 
ATOM 696  N NZ    . LYS A 1 145 ? 139.117 112.939 107.676 1.00 46.54  ? 145 LYS A NZ    1 
ATOM 697  N N     . LYS A 1 146 ? 133.795 109.959 109.363 1.00 48.97  ? 146 LYS A N     1 
ATOM 698  C CA    . LYS A 1 146 ? 133.846 108.965 110.431 1.00 48.97  ? 146 LYS A CA    1 
ATOM 699  C C     . LYS A 1 146 ? 133.979 107.558 109.867 1.00 48.97  ? 146 LYS A C     1 
ATOM 700  O O     . LYS A 1 146 ? 134.688 106.717 110.433 1.00 48.97  ? 146 LYS A O     1 
ATOM 701  C CB    . LYS A 1 146 ? 132.595 109.071 111.301 1.00 48.97  ? 146 LYS A CB    1 
ATOM 702  C CG    . LYS A 1 146 ? 132.645 108.256 112.581 1.00 48.97  ? 146 LYS A CG    1 
ATOM 703  C CD    . LYS A 1 146 ? 131.280 108.218 113.248 1.00 48.97  ? 146 LYS A CD    1 
ATOM 704  C CE    . LYS A 1 146 ? 131.398 108.269 114.759 1.00 48.97  ? 146 LYS A CE    1 
ATOM 705  N NZ    . LYS A 1 146 ? 132.575 107.498 115.239 1.00 48.97  ? 146 LYS A NZ    1 
ATOM 706  N N     . VAL A 1 147 ? 133.291 107.296 108.764 1.00 52.54  ? 147 VAL A N     1 
ATOM 707  C CA    . VAL A 1 147 ? 133.367 105.992 108.127 1.00 52.54  ? 147 VAL A CA    1 
ATOM 708  C C     . VAL A 1 147 ? 134.766 105.755 107.563 1.00 52.54  ? 147 VAL A C     1 
ATOM 709  O O     . VAL A 1 147 ? 135.384 104.734 107.842 1.00 52.54  ? 147 VAL A O     1 
ATOM 710  C CB    . VAL A 1 147 ? 132.292 105.843 107.033 1.00 52.54  ? 147 VAL A CB    1 
ATOM 711  C CG1   . VAL A 1 147 ? 132.626 104.702 106.089 1.00 52.54  ? 147 VAL A CG1   1 
ATOM 712  C CG2   . VAL A 1 147 ? 130.930 105.632 107.671 1.00 52.54  ? 147 VAL A CG2   1 
ATOM 713  N N     . GLU A 1 148 ? 135.268 106.718 106.798 1.00 58.01  ? 148 GLU A N     1 
ATOM 714  C CA    . GLU A 1 148 ? 136.491 106.546 106.027 1.00 58.01  ? 148 GLU A CA    1 
ATOM 715  C C     . GLU A 1 148 ? 137.744 106.979 106.777 1.00 58.01  ? 148 GLU A C     1 
ATOM 716  O O     . GLU A 1 148 ? 138.831 106.972 106.193 1.00 58.01  ? 148 GLU A O     1 
ATOM 717  C CB    . GLU A 1 148 ? 136.388 107.288 104.693 1.00 58.01  ? 148 GLU A CB    1 
ATOM 718  C CG    . GLU A 1 148 ? 135.406 106.647 103.725 1.00 58.01  ? 148 GLU A CG    1 
ATOM 719  C CD    . GLU A 1 148 ? 135.307 107.387 102.407 1.00 58.01  ? 148 GLU A CD    1 
ATOM 720  O OE1   . GLU A 1 148 ? 135.923 108.467 102.281 1.00 58.01  ? 148 GLU A OE1   1 
ATOM 721  O OE2   . GLU A 1 148 ? 134.617 106.885 101.496 1.00 58.01  ? 148 GLU A OE2   1 
ATOM 722  N N     . THR A 1 149 ? 137.622 107.369 108.043 1.00 57.19  ? 149 THR A N     1 
ATOM 723  C CA    . THR A 1 149 ? 138.763 107.402 108.948 1.00 57.19  ? 149 THR A CA    1 
ATOM 724  C C     . THR A 1 149 ? 138.888 106.107 109.736 1.00 57.19  ? 149 THR A C     1 
ATOM 725  O O     . THR A 1 149 ? 139.865 105.924 110.469 1.00 57.19  ? 149 THR A O     1 
ATOM 726  C CB    . THR A 1 149 ? 138.669 108.594 109.902 1.00 57.19  ? 149 THR A CB    1 
ATOM 727  O OG1   . THR A 1 149 ? 137.418 108.558 110.601 1.00 57.19  ? 149 THR A OG1   1 
ATOM 728  C CG2   . THR A 1 149 ? 138.804 109.904 109.141 1.00 57.19  ? 149 THR A CG2   1 
ATOM 729  N N     . ARG A 1 150 ? 137.917 105.208 109.593 1.00 64.86  ? 150 ARG A N     1 
ATOM 730  C CA    . ARG A 1 150 ? 137.957 103.882 110.190 1.00 64.86  ? 150 ARG A CA    1 
ATOM 731  C C     . ARG A 1 150 ? 138.197 102.858 109.093 1.00 64.86  ? 150 ARG A C     1 
ATOM 732  O O     . ARG A 1 150 ? 138.994 101.928 109.256 1.00 64.86  ? 150 ARG A O     1 
ATOM 733  C CB    . ARG A 1 150 ? 136.650 103.583 110.925 1.00 64.86  ? 150 ARG A CB    1 
ATOM 734  C CG    . ARG A 1 150 ? 136.470 104.336 112.231 1.00 64.86  ? 150 ARG A CG    1 
ATOM 735  C CD    . ARG A 1 150 ? 135.034 104.233 112.721 1.00 64.86  ? 150 ARG A CD    1 
ATOM 736  N NE    . ARG A 1 150 ? 134.558 102.855 112.733 1.00 64.86  ? 150 ARG A NE    1 
ATOM 737  C CZ    . ARG A 1 150 ? 133.567 102.399 111.979 1.00 64.86  ? 150 ARG A CZ    1 
ATOM 738  N NH1   . ARG A 1 150 ? 132.909 103.190 111.150 1.00 64.86  ? 150 ARG A NH1   1 
ATOM 739  N NH2   . ARG A 1 150 ? 133.228 101.116 112.061 1.00 64.86  ? 150 ARG A NH2   1 
ATOM 740  N N     . ASN A 1 151 ? 137.501 103.028 107.971 1.00 75.91  ? 151 ASN A N     1 
ATOM 741  C CA    . ASN A 1 151 ? 137.677 102.179 106.802 1.00 75.91  ? 151 ASN A CA    1 
ATOM 742  C C     . ASN A 1 151 ? 139.092 102.357 106.263 1.00 75.91  ? 151 ASN A C     1 
ATOM 743  O O     . ASN A 1 151 ? 139.671 101.425 105.696 1.00 75.91  ? 151 ASN A O     1 
ATOM 744  C CB    . ASN A 1 151 ? 136.625 102.522 105.743 1.00 75.91  ? 151 ASN A CB    1 
ATOM 745  C CG    . ASN A 1 151 ? 136.588 101.528 104.601 1.00 75.91  ? 151 ASN A CG    1 
ATOM 746  O OD1   . ASN A 1 151 ? 135.783 101.645 103.678 1.00 75.91  ? 151 ASN A OD1   1 
ATOM 747  N ND2   . ASN A 1 151 ? 137.473 100.540 104.656 1.00 75.91  ? 151 ASN A ND2   1 
ATOM 748  N N     . GLU A 1 152 ? 139.652 103.548 106.456 1.00 82.89  ? 152 GLU A N     1 
ATOM 749  C CA    . GLU A 1 152 ? 141.044 103.817 106.107 1.00 82.89  ? 152 GLU A CA    1 
ATOM 750  C C     . GLU A 1 152 ? 141.973 102.903 106.890 1.00 82.89  ? 152 GLU A C     1 
ATOM 751  O O     . GLU A 1 152 ? 142.949 102.397 106.357 1.00 82.89  ? 152 GLU A O     1 
ATOM 752  C CB    . GLU A 1 152 ? 141.394 105.269 106.414 1.00 82.89  ? 152 GLU A CB    1 
ATOM 753  C CG    . GLU A 1 152 ? 142.775 105.706 105.963 1.00 82.89  ? 152 GLU A CG    1 
ATOM 754  C CD    . GLU A 1 152 ? 143.072 107.143 106.338 1.00 82.89  ? 152 GLU A CD    1 
ATOM 755  O OE1   . GLU A 1 152 ? 142.191 107.791 106.943 1.00 82.89  ? 152 GLU A OE1   1 
ATOM 756  O OE2   . GLU A 1 152 ? 144.182 107.623 106.030 1.00 82.89  ? 152 GLU A OE2   1 
ATOM 757  N N     . LYS A 1 153 ? 141.658 102.719 108.165 1.00 86.52  ? 153 LYS A N     1 
ATOM 758  C CA    . LYS A 1 153 ? 142.377 101.816 109.058 1.00 86.52  ? 153 LYS A CA    1 
ATOM 759  C C     . LYS A 1 153 ? 142.107 100.346 108.713 1.00 86.52  ? 153 LYS A C     1 
ATOM 760  O O     . LYS A 1 153 ? 142.909 99.476  109.032 1.00 86.52  ? 153 LYS A O     1 
ATOM 761  C CB    . LYS A 1 153 ? 141.988 102.105 110.509 1.00 86.52  ? 153 LYS A CB    1 
ATOM 762  C CG    . LYS A 1 153 ? 142.923 101.529 111.557 1.00 86.52  ? 153 LYS A CG    1 
ATOM 763  C CD    . LYS A 1 153 ? 142.360 101.752 112.950 1.00 86.52  ? 153 LYS A CD    1 
ATOM 764  C CE    . LYS A 1 153 ? 141.998 103.213 113.166 1.00 86.52  ? 153 LYS A CE    1 
ATOM 765  N NZ    . LYS A 1 153 ? 141.390 103.444 114.505 1.00 86.52  ? 153 LYS A NZ    1 
ATOM 766  N N     . ARG A 1 154 ? 140.974 100.079 108.068 1.00 90.41  ? 154 ARG A N     1 
ATOM 767  C CA    . ARG A 1 154 ? 140.689 98.777  107.477 1.00 90.41  ? 154 ARG A CA    1 
ATOM 768  C C     . ARG A 1 154 ? 141.512 98.563  106.213 1.00 90.41  ? 154 ARG A C     1 
ATOM 769  O O     . ARG A 1 154 ? 142.029 97.464  105.978 1.00 90.41  ? 154 ARG A O     1 
ATOM 770  C CB    . ARG A 1 154 ? 139.194 98.653  107.182 1.00 90.41  ? 154 ARG A CB    1 
ATOM 771  C CG    . ARG A 1 154 ? 138.770 97.300  106.644 1.00 90.41  ? 154 ARG A CG    1 
ATOM 772  C CD    . ARG A 1 154 ? 137.259 97.162  106.677 1.00 90.41  ? 154 ARG A CD    1 
ATOM 773  N NE    . ARG A 1 154 ? 136.753 97.116  108.043 1.00 90.41  ? 154 ARG A NE    1 
ATOM 774  C CZ    . ARG A 1 154 ? 135.474 97.233  108.373 1.00 90.41  ? 154 ARG A CZ    1 
ATOM 775  N NH1   . ARG A 1 154 ? 134.536 97.402  107.456 1.00 90.41  ? 154 ARG A NH1   1 
ATOM 776  N NH2   . ARG A 1 154 ? 135.128 97.180  109.656 1.00 90.41  ? 154 ARG A NH2   1 
ATOM 777  N N     . ARG A 1 155 ? 141.705 99.611  105.419 1.00 91.36  ? 155 ARG A N     1 
ATOM 778  C CA    . ARG A 1 155 ? 142.595 99.495  104.265 1.00 91.36  ? 155 ARG A CA    1 
ATOM 779  C C     . ARG A 1 155 ? 144.067 99.675  104.664 1.00 91.36  ? 155 ARG A C     1 
ATOM 780  O O     . ARG A 1 155 ? 144.969 99.317  103.905 1.00 91.36  ? 155 ARG A O     1 
ATOM 781  C CB    . ARG A 1 155 ? 142.181 100.439 103.127 1.00 91.36  ? 155 ARG A CB    1 
ATOM 782  C CG    . ARG A 1 155 ? 142.655 101.876 103.260 1.00 91.36  ? 155 ARG A CG    1 
ATOM 783  C CD    . ARG A 1 155 ? 141.982 102.805 102.259 1.00 91.36  ? 155 ARG A CD    1 
ATOM 784  N NE    . ARG A 1 155 ? 142.318 102.487 100.873 1.00 91.36  ? 155 ARG A NE    1 
ATOM 785  C CZ    . ARG A 1 155 ? 141.488 101.908 100.011 1.00 91.36  ? 155 ARG A CZ    1 
ATOM 786  N NH1   . ARG A 1 155 ? 140.256 101.585 100.382 1.00 91.36  ? 155 ARG A NH1   1 
ATOM 787  N NH2   . ARG A 1 155 ? 141.888 101.658 98.771  1.00 91.36  ? 155 ARG A NH2   1 
ATOM 788  N N     . SER A 1 156 ? 144.305 100.206 105.863 1.00 98.61  ? 156 SER A N     1 
ATOM 789  C CA    . SER A 1 156 ? 145.599 100.057 106.518 1.00 98.61  ? 156 SER A CA    1 
ATOM 790  C C     . SER A 1 156 ? 145.751 98.669  107.123 1.00 98.61  ? 156 SER A C     1 
ATOM 791  O O     . SER A 1 156 ? 146.866 98.138  107.186 1.00 98.61  ? 156 SER A O     1 
ATOM 792  C CB    . SER A 1 156 ? 145.777 101.132 107.590 1.00 98.61  ? 156 SER A CB    1 
ATOM 793  O OG    . SER A 1 156 ? 146.996 100.956 108.290 1.00 98.61  ? 156 SER A OG    1 
ATOM 794  N N     . LYS A 1 157 ? 144.654 98.022  107.489 1.00 103.82 ? 157 LYS A N     1 
ATOM 795  C CA    . LYS A 1 157 ? 144.702 96.656  107.993 1.00 103.82 ? 157 LYS A CA    1 
ATOM 796  C C     . LYS A 1 157 ? 145.028 95.740  106.830 1.00 103.82 ? 157 LYS A C     1 
ATOM 797  O O     . LYS A 1 157 ? 145.761 94.766  106.985 1.00 103.82 ? 157 LYS A O     1 
ATOM 798  C CB    . LYS A 1 157 ? 143.369 96.266  108.637 1.00 103.82 ? 157 LYS A CB    1 
ATOM 799  C CG    . LYS A 1 157 ? 143.194 94.785  108.921 1.00 103.82 ? 157 LYS A CG    1 
ATOM 800  C CD    . LYS A 1 157 ? 141.740 94.463  109.223 1.00 103.82 ? 157 LYS A CD    1 
ATOM 801  C CE    . LYS A 1 157 ? 141.524 92.965  109.359 1.00 103.82 ? 157 LYS A CE    1 
ATOM 802  N NZ    . LYS A 1 157 ? 140.096 92.634  109.620 1.00 103.82 ? 157 LYS A NZ    1 
ATOM 803  N N     . ALA A 1 158 ? 144.503 96.068  105.653 1.00 110.43 ? 158 ALA A N     1 
ATOM 804  C CA    . ALA A 1 158 ? 144.901 95.336  104.457 1.00 110.43 ? 158 ALA A CA    1 
ATOM 805  C C     . ALA A 1 158 ? 146.391 95.490  104.188 1.00 110.43 ? 158 ALA A C     1 
ATOM 806  O O     . ALA A 1 158 ? 147.033 94.553  103.704 1.00 110.43 ? 158 ALA A O     1 
ATOM 807  C CB    . ALA A 1 158 ? 144.088 95.806  103.251 1.00 110.43 ? 158 ALA A CB    1 
ATOM 808  N N     . THR A 1 159 ? 146.957 96.659  104.492 1.00 113.49 ? 159 THR A N     1 
ATOM 809  C CA    . THR A 1 159 ? 148.405 96.818  104.408 1.00 113.49 ? 159 THR A CA    1 
ATOM 810  C C     . THR A 1 159 ? 149.110 95.940  105.436 1.00 113.49 ? 159 THR A C     1 
ATOM 811  O O     . THR A 1 159 ? 150.135 95.319  105.132 1.00 113.49 ? 159 THR A O     1 
ATOM 812  C CB    . THR A 1 159 ? 148.787 98.287  104.596 1.00 113.49 ? 159 THR A CB    1 
ATOM 813  O OG1   . THR A 1 159 ? 148.225 99.068  103.533 1.00 113.49 ? 159 THR A OG1   1 
ATOM 814  C CG2   . THR A 1 159 ? 150.300 98.456  104.591 1.00 113.49 ? 159 THR A CG2   1 
ATOM 815  N N     . ARG A 1 160 ? 148.566 95.865  106.653 1.00 116.20 ? 160 ARG A N     1 
ATOM 816  C CA    . ARG A 1 160 ? 149.197 95.073  107.707 1.00 116.20 ? 160 ARG A CA    1 
ATOM 817  C C     . ARG A 1 160 ? 149.266 93.598  107.329 1.00 116.20 ? 160 ARG A C     1 
ATOM 818  O O     . ARG A 1 160 ? 150.307 92.952  107.496 1.00 116.20 ? 160 ARG A O     1 
ATOM 819  C CB    . ARG A 1 160 ? 148.442 95.257  109.025 1.00 116.20 ? 160 ARG A CB    1 
ATOM 820  C CG    . ARG A 1 160 ? 148.473 96.676  109.589 1.00 116.20 ? 160 ARG A CG    1 
ATOM 821  C CD    . ARG A 1 160 ? 149.802 96.996  110.268 1.00 116.20 ? 160 ARG A CD    1 
ATOM 822  N NE    . ARG A 1 160 ? 150.879 97.263  109.323 1.00 116.20 ? 160 ARG A NE    1 
ATOM 823  C CZ    . ARG A 1 160 ? 151.044 98.409  108.676 1.00 116.20 ? 160 ARG A CZ    1 
ATOM 824  N NH1   . ARG A 1 160 ? 150.216 99.426  108.849 1.00 116.20 ? 160 ARG A NH1   1 
ATOM 825  N NH2   . ARG A 1 160 ? 152.066 98.537  107.835 1.00 116.20 ? 160 ARG A NH2   1 
ATOM 826  N N     . ILE A 1 161 ? 148.163 93.043  106.823 1.00 121.40 ? 161 ILE A N     1 
ATOM 827  C CA    . ILE A 1 161 ? 148.174 91.642  106.412 1.00 121.40 ? 161 ILE A CA    1 
ATOM 828  C C     . ILE A 1 161 ? 149.036 91.457  105.169 1.00 121.40 ? 161 ILE A C     1 
ATOM 829  O O     . ILE A 1 161 ? 149.683 90.417  104.995 1.00 121.40 ? 161 ILE A O     1 
ATOM 830  C CB    . ILE A 1 161 ? 146.738 91.125  106.200 1.00 121.40 ? 161 ILE A CB    1 
ATOM 831  C CG1   . ILE A 1 161 ? 145.994 91.977  105.172 1.00 121.40 ? 161 ILE A CG1   1 
ATOM 832  C CG2   . ILE A 1 161 ? 145.978 91.099  107.520 1.00 121.40 ? 161 ILE A CG2   1 
ATOM 833  C CD1   . ILE A 1 161 ? 144.656 91.405  104.764 1.00 121.40 ? 161 ILE A CD1   1 
ATOM 834  N N     . ASN A 1 162 ? 149.057 92.455  104.282 1.00 126.76 ? 162 ASN A N     1 
ATOM 835  C CA    . ASN A 1 162 ? 149.884 92.354  103.084 1.00 126.76 ? 162 ASN A CA    1 
ATOM 836  C C     . ASN A 1 162 ? 151.367 92.312  103.425 1.00 126.76 ? 162 ASN A C     1 
ATOM 837  O O     . ASN A 1 162 ? 152.103 91.484  102.882 1.00 126.76 ? 162 ASN A O     1 
ATOM 838  C CB    . ASN A 1 162 ? 149.589 93.510  102.128 1.00 126.76 ? 162 ASN A CB    1 
ATOM 839  C CG    . ASN A 1 162 ? 148.293 93.320  101.365 1.00 126.76 ? 162 ASN A CG    1 
ATOM 840  O OD1   . ASN A 1 162 ? 147.636 92.290  101.487 1.00 126.76 ? 162 ASN A OD1   1 
ATOM 841  N ND2   . ASN A 1 162 ? 147.924 94.312  100.566 1.00 126.76 ? 162 ASN A ND2   1 
ATOM 842  N N     . VAL A 1 163 ? 151.821 93.172  104.344 1.00 129.36 ? 163 VAL A N     1 
ATOM 843  C CA    . VAL A 1 163 ? 153.256 93.295  104.605 1.00 129.36 ? 163 VAL A CA    1 
ATOM 844  C C     . VAL A 1 163 ? 153.854 91.945  104.976 1.00 129.36 ? 163 VAL A C     1 
ATOM 845  O O     . VAL A 1 163 ? 154.932 91.573  104.494 1.00 129.36 ? 163 VAL A O     1 
ATOM 846  C CB    . VAL A 1 163 ? 153.516 94.349  105.699 1.00 129.36 ? 163 VAL A CB    1 
ATOM 847  C CG1   . VAL A 1 163 ? 154.949 94.256  106.197 1.00 129.36 ? 163 VAL A CG1   1 
ATOM 848  C CG2   . VAL A 1 163 ? 153.247 95.742  105.164 1.00 129.36 ? 163 VAL A CG2   1 
ATOM 849  N N     . SER A 1 164 ? 153.161 91.184  105.825 1.00 135.08 ? 164 SER A N     1 
ATOM 850  C CA    . SER A 1 164 ? 153.629 89.846  106.165 1.00 135.08 ? 164 SER A CA    1 
ATOM 851  C C     . SER A 1 164 ? 153.496 88.893  104.980 1.00 135.08 ? 164 SER A C     1 
ATOM 852  O O     . SER A 1 164 ? 154.147 87.842  104.943 1.00 135.08 ? 164 SER A O     1 
ATOM 853  C CB    . SER A 1 164 ? 152.852 89.313  107.372 1.00 135.08 ? 164 SER A CB    1 
ATOM 854  O OG    . SER A 1 164 ? 152.855 90.251  108.435 1.00 135.08 ? 164 SER A OG    1 
ATOM 855  N N     . ARG A 1 165 ? 152.653 89.240  104.002 1.00 138.95 ? 165 ARG A N     1 
ATOM 856  C CA    . ARG A 1 165 ? 152.306 88.279  102.957 1.00 138.95 ? 165 ARG A CA    1 
ATOM 857  C C     . ARG A 1 165 ? 153.426 88.115  101.930 1.00 138.95 ? 165 ARG A C     1 
ATOM 858  O O     . ARG A 1 165 ? 153.719 86.990  101.507 1.00 138.95 ? 165 ARG A O     1 
ATOM 859  C CB    . ARG A 1 165 ? 150.996 88.684  102.283 1.00 138.95 ? 165 ARG A CB    1 
ATOM 860  C CG    . ARG A 1 165 ? 150.548 87.725  101.201 1.00 138.95 ? 165 ARG A CG    1 
ATOM 861  C CD    . ARG A 1 165 ? 150.241 86.355  101.794 1.00 138.95 ? 165 ARG A CD    1 
ATOM 862  N NE    . ARG A 1 165 ? 149.131 86.376  102.740 1.00 138.95 ? 165 ARG A NE    1 
ATOM 863  C CZ    . ARG A 1 165 ? 148.825 85.374  103.552 1.00 138.95 ? 165 ARG A CZ    1 
ATOM 864  N NH1   . ARG A 1 165 ? 149.525 84.251  103.558 1.00 138.95 ? 165 ARG A NH1   1 
ATOM 865  N NH2   . ARG A 1 165 ? 147.791 85.499  104.379 1.00 138.95 ? 165 ARG A NH2   1 
ATOM 866  N N     . GLU A 1 166 ? 154.065 89.213  101.504 1.00 138.99 ? 166 GLU A N     1 
ATOM 867  C CA    . GLU A 1 166 ? 155.194 89.062  100.585 1.00 138.99 ? 166 GLU A CA    1 
ATOM 868  C C     . GLU A 1 166 ? 156.377 88.394  101.275 1.00 138.99 ? 166 GLU A C     1 
ATOM 869  O O     . GLU A 1 166 ? 157.165 87.693  100.629 1.00 138.99 ? 166 GLU A O     1 
ATOM 870  C CB    . GLU A 1 166 ? 155.633 90.401  99.980  1.00 138.99 ? 166 GLU A CB    1 
ATOM 871  C CG    . GLU A 1 166 ? 154.633 91.060  99.039  1.00 138.99 ? 166 GLU A CG    1 
ATOM 872  C CD    . GLU A 1 166 ? 153.590 91.853  99.774  1.00 138.99 ? 166 GLU A CD    1 
ATOM 873  O OE1   . GLU A 1 166 ? 153.703 91.935  101.006 1.00 138.99 ? 166 GLU A OE1   1 
ATOM 874  O OE2   . GLU A 1 166 ? 152.669 92.392  99.129  1.00 138.99 ? 166 GLU A OE2   1 
ATOM 875  N N     . ALA A 1 167 ? 156.530 88.613  102.584 1.00 141.42 ? 167 ALA A N     1 
ATOM 876  C CA    . ALA A 1 167 ? 157.571 87.911  103.328 1.00 141.42 ? 167 ALA A CA    1 
ATOM 877  C C     . ALA A 1 167 ? 157.348 86.404  103.289 1.00 141.42 ? 167 ALA A C     1 
ATOM 878  O O     . ALA A 1 167 ? 158.298 85.633  103.114 1.00 141.42 ? 167 ALA A O     1 
ATOM 879  C CB    . ALA A 1 167 ? 157.616 88.409  104.772 1.00 141.42 ? 167 ALA A CB    1 
ATOM 880  N N     . ASP A 1 168 ? 156.097 85.966  103.454 1.00 142.54 ? 168 ASP A N     1 
ATOM 881  C CA    . ASP A 1 168 ? 155.787 84.547  103.306 1.00 142.54 ? 168 ASP A CA    1 
ATOM 882  C C     . ASP A 1 168 ? 155.838 84.125  101.843 1.00 142.54 ? 168 ASP A C     1 
ATOM 883  O O     . ASP A 1 168 ? 156.209 82.988  101.528 1.00 142.54 ? 168 ASP A O     1 
ATOM 884  C CB    . ASP A 1 168 ? 154.414 84.244  103.907 1.00 142.54 ? 168 ASP A CB    1 
ATOM 885  C CG    . ASP A 1 168 ? 154.357 84.514  105.397 1.00 142.54 ? 168 ASP A CG    1 
ATOM 886  O OD1   . ASP A 1 168 ? 155.428 84.715  106.008 1.00 142.54 ? 168 ASP A OD1   1 
ATOM 887  O OD2   . ASP A 1 168 ? 153.241 84.531  105.958 1.00 142.54 ? 168 ASP A OD2   1 
ATOM 888  N N     . GLY A 1 169 ? 155.470 85.028  100.936 1.00 144.24 ? 169 GLY A N     1 
ATOM 889  C CA    . GLY A 1 169 ? 155.457 84.741  99.518  1.00 144.24 ? 169 GLY A CA    1 
ATOM 890  C C     . GLY A 1 169 ? 154.154 84.188  98.984  1.00 144.24 ? 169 GLY A C     1 
ATOM 891  O O     . GLY A 1 169 ? 154.031 84.004  97.766  1.00 144.24 ? 169 GLY A O     1 
ATOM 892  N N     . LEU A 1 170 ? 153.181 83.919  99.850  1.00 145.27 ? 170 LEU A N     1 
ATOM 893  C CA    . LEU A 1 170 ? 151.909 83.377  99.408  1.00 145.27 ? 170 LEU A CA    1 
ATOM 894  C C     . LEU A 1 170 ? 151.073 84.462  98.727  1.00 145.27 ? 170 LEU A C     1 
ATOM 895  O O     . LEU A 1 170 ? 151.336 85.655  98.894  1.00 145.27 ? 170 LEU A O     1 
ATOM 896  C CB    . LEU A 1 170 ? 151.143 82.792  100.592 1.00 145.27 ? 170 LEU A CB    1 
ATOM 897  C CG    . LEU A 1 170 ? 151.798 81.599  101.290 1.00 145.27 ? 170 LEU A CG    1 
ATOM 898  C CD1   . LEU A 1 170 ? 150.990 81.177  102.508 1.00 145.27 ? 170 LEU A CD1   1 
ATOM 899  C CD2   . LEU A 1 170 ? 151.965 80.437  100.324 1.00 145.27 ? 170 LEU A CD2   1 
ATOM 900  N N     . PRO A 1 171 ? 150.075 84.072  97.928  1.00 145.59 ? 171 PRO A N     1 
ATOM 901  C CA    . PRO A 1 171 ? 149.154 85.066  97.382  1.00 145.59 ? 171 PRO A CA    1 
ATOM 902  C C     . PRO A 1 171 ? 148.369 85.739  98.492  1.00 145.59 ? 171 PRO A C     1 
ATOM 903  O O     . PRO A 1 171 ? 148.134 85.141  99.556  1.00 145.59 ? 171 PRO A O     1 
ATOM 904  C CB    . PRO A 1 171 ? 148.235 84.235  96.466  1.00 145.59 ? 171 PRO A CB    1 
ATOM 905  C CG    . PRO A 1 171 ? 148.412 82.821  96.908  1.00 145.59 ? 171 PRO A CG    1 
ATOM 906  C CD    . PRO A 1 171 ? 149.822 82.726  97.386  1.00 145.59 ? 171 PRO A CD    1 
ATOM 907  N N     . PRO A 1 172 ? 147.956 86.992  98.299  1.00 142.61 ? 172 PRO A N     1 
ATOM 908  C CA    . PRO A 1 172 ? 147.236 87.707  99.362  1.00 142.61 ? 172 PRO A CA    1 
ATOM 909  C C     . PRO A 1 172 ? 145.945 87.000  99.751  1.00 142.61 ? 172 PRO A C     1 
ATOM 910  O O     . PRO A 1 172 ? 145.240 86.439  98.910  1.00 142.61 ? 172 PRO A O     1 
ATOM 911  C CB    . PRO A 1 172 ? 146.958 89.080  98.739  1.00 142.61 ? 172 PRO A CB    1 
ATOM 912  C CG    . PRO A 1 172 ? 147.998 89.233  97.678  1.00 142.61 ? 172 PRO A CG    1 
ATOM 913  C CD    . PRO A 1 172 ? 148.217 87.852  97.132  1.00 142.61 ? 172 PRO A CD    1 
ATOM 914  N N     . ILE A 1 173 ? 145.641 87.037  101.051 1.00 137.62 ? 173 ILE A N     1 
ATOM 915  C CA    . ILE A 1 173 ? 144.432 86.397  101.553 1.00 137.62 ? 173 ILE A CA    1 
ATOM 916  C C     . ILE A 1 173 ? 143.232 87.320  101.351 1.00 137.62 ? 173 ILE A C     1 
ATOM 917  O O     . ILE A 1 173 ? 143.362 88.539  101.183 1.00 137.62 ? 173 ILE A O     1 
ATOM 918  C CB    . ILE A 1 173 ? 144.604 86.012  103.033 1.00 137.62 ? 173 ILE A CB    1 
ATOM 919  C CG1   . ILE A 1 173 ? 143.556 84.980  103.462 1.00 137.62 ? 173 ILE A CG1   1 
ATOM 920  C CG2   . ILE A 1 173 ? 144.532 87.248  103.920 1.00 137.62 ? 173 ILE A CG2   1 
ATOM 921  C CD1   . ILE A 1 173 ? 143.704 83.639  102.777 1.00 137.62 ? 173 ILE A CD1   1 
ATOM 922  N N     . GLU A 1 174 ? 142.043 86.720  101.354 1.00 129.91 ? 174 GLU A N     1 
ATOM 923  C CA    . GLU A 1 174 ? 140.814 87.488  101.207 1.00 129.91 ? 174 GLU A CA    1 
ATOM 924  C C     . GLU A 1 174 ? 140.639 88.445  102.380 1.00 129.91 ? 174 GLU A C     1 
ATOM 925  O O     . GLU A 1 174 ? 141.000 88.135  103.519 1.00 129.91 ? 174 GLU A O     1 
ATOM 926  C CB    . GLU A 1 174 ? 139.611 86.549  101.108 1.00 129.91 ? 174 GLU A CB    1 
ATOM 927  C CG    . GLU A 1 174 ? 138.441 87.116  100.321 1.00 129.91 ? 174 GLU A CG    1 
ATOM 928  C CD    . GLU A 1 174 ? 137.451 87.856  101.199 1.00 129.91 ? 174 GLU A CD    1 
ATOM 929  O OE1   . GLU A 1 174 ? 137.470 87.641  102.429 1.00 129.91 ? 174 GLU A OE1   1 
ATOM 930  O OE2   . GLU A 1 174 ? 136.654 88.651  100.659 1.00 129.91 ? 174 GLU A OE2   1 
ATOM 931  N N     . ALA A 1 175 ? 140.079 89.618  102.095 1.00 118.46 ? 175 ALA A N     1 
ATOM 932  C CA    . ALA A 1 175 ? 139.892 90.660  103.092 1.00 118.46 ? 175 ALA A CA    1 
ATOM 933  C C     . ALA A 1 175 ? 138.446 91.133  103.079 1.00 118.46 ? 175 ALA A C     1 
ATOM 934  O O     . ALA A 1 175 ? 137.729 90.988  102.085 1.00 118.46 ? 175 ALA A O     1 
ATOM 935  C CB    . ALA A 1 175 ? 140.836 91.846  102.853 1.00 118.46 ? 175 ALA A CB    1 
ATOM 936  N N     . GLU A 1 176 ? 138.084 91.734  104.209 1.00 100.83 ? 176 GLU A N     1 
ATOM 937  C CA    . GLU A 1 176 ? 136.817 92.406  104.419 1.00 100.83 ? 176 GLU A CA    1 
ATOM 938  C C     . GLU A 1 176 ? 136.515 93.470  103.345 1.00 100.83 ? 176 GLU A C     1 
ATOM 939  O O     . GLU A 1 176 ? 137.426 94.186  102.924 1.00 100.83 ? 176 GLU A O     1 
ATOM 940  C CB    . GLU A 1 176 ? 136.773 93.049  105.811 1.00 100.83 ? 176 GLU A CB    1 
ATOM 941  C CG    . GLU A 1 176 ? 136.580 92.068  106.959 1.00 100.83 ? 176 GLU A CG    1 
ATOM 942  C CD    . GLU A 1 176 ? 137.862 91.368  107.372 1.00 100.83 ? 176 GLU A CD    1 
ATOM 943  O OE1   . GLU A 1 176 ? 138.954 91.834  106.983 1.00 100.83 ? 176 GLU A OE1   1 
ATOM 944  O OE2   . GLU A 1 176 ? 137.778 90.354  108.095 1.00 100.83 ? 176 GLU A OE2   1 
ATOM 945  N N     . PRO A 1 177 ? 135.236 93.597  102.905 1.00 90.10  ? 177 PRO A N     1 
ATOM 946  C CA    . PRO A 1 177 ? 134.988 94.707  101.976 1.00 90.10  ? 177 PRO A CA    1 
ATOM 947  C C     . PRO A 1 177 ? 134.834 96.046  102.677 1.00 90.10  ? 177 PRO A C     1 
ATOM 948  O O     . PRO A 1 177 ? 135.012 96.147  103.895 1.00 90.10  ? 177 PRO A O     1 
ATOM 949  C CB    . PRO A 1 177 ? 133.690 94.287  101.280 1.00 90.10  ? 177 PRO A CB    1 
ATOM 950  C CG    . PRO A 1 177 ? 132.969 93.503  102.322 1.00 90.10  ? 177 PRO A CG    1 
ATOM 951  C CD    . PRO A 1 177 ? 134.033 92.767  103.103 1.00 90.10  ? 177 PRO A CD    1 
ATOM 952  N N     . GLU A 1 178 ? 134.504 97.081  101.911 1.00 75.80  ? 178 GLU A N     1 
ATOM 953  C CA    . GLU A 1 178 ? 134.334 98.433  102.426 1.00 75.80  ? 178 GLU A CA    1 
ATOM 954  C C     . GLU A 1 178 ? 132.864 98.682  102.729 1.00 75.80  ? 178 GLU A C     1 
ATOM 955  O O     . GLU A 1 178 ? 131.988 98.264  101.965 1.00 75.80  ? 178 GLU A O     1 
ATOM 956  C CB    . GLU A 1 178 ? 134.855 99.468  101.427 1.00 75.80  ? 178 GLU A CB    1 
ATOM 957  C CG    . GLU A 1 178 ? 134.321 99.299  100.013 1.00 75.80  ? 178 GLU A CG    1 
ATOM 958  C CD    . GLU A 1 178 ? 134.516 100.540 99.164  1.00 75.80  ? 178 GLU A CD    1 
ATOM 959  O OE1   . GLU A 1 178 ? 134.834 101.606 99.732  1.00 75.80  ? 178 GLU A OE1   1 
ATOM 960  O OE2   . GLU A 1 178 ? 134.352 100.449 97.930  1.00 75.80  ? 178 GLU A OE2   1 
ATOM 961  N N     . GLU A 1 179 ? 132.598 99.357  103.844 1.00 59.39  ? 179 GLU A N     1 
ATOM 962  C CA    . GLU A 1 179 ? 131.243 99.670  104.283 1.00 59.39  ? 179 GLU A CA    1 
ATOM 963  C C     . GLU A 1 179 ? 131.019 101.167 104.115 1.00 59.39  ? 179 GLU A C     1 
ATOM 964  O O     . GLU A 1 179 ? 131.781 101.977 104.650 1.00 59.39  ? 179 GLU A O     1 
ATOM 965  C CB    . GLU A 1 179 ? 131.026 99.241  105.731 1.00 59.39  ? 179 GLU A CB    1 
ATOM 966  N N     . THR A 1 180 ? 129.979 101.530 103.373 1.00 48.35  ? 180 THR A N     1 
ATOM 967  C CA    . THR A 1 180 ? 129.657 102.925 103.124 1.00 48.35  ? 180 THR A CA    1 
ATOM 968  C C     . THR A 1 180 ? 128.809 103.495 104.258 1.00 48.35  ? 180 THR A C     1 
ATOM 969  O O     . THR A 1 180 ? 128.598 102.864 105.295 1.00 48.35  ? 180 THR A O     1 
ATOM 970  C CB    . THR A 1 180 ? 128.929 103.078 101.789 1.00 48.35  ? 180 THR A CB    1 
ATOM 971  O OG1   . THR A 1 180 ? 127.698 102.345 101.827 1.00 48.35  ? 180 THR A OG1   1 
ATOM 972  C CG2   . THR A 1 180 ? 129.791 102.553 100.651 1.00 48.35  ? 180 THR A CG2   1 
ATOM 973  N N     . ALA A 1 181 ? 128.319 104.715 104.046 1.00 43.68  ? 181 ALA A N     1 
ATOM 974  C CA    . ALA A 1 181 ? 127.482 105.405 105.015 1.00 43.68  ? 181 ALA A CA    1 
ATOM 975  C C     . ALA A 1 181 ? 126.088 105.712 104.482 1.00 43.68  ? 181 ALA A C     1 
ATOM 976  O O     . ALA A 1 181 ? 125.295 106.349 105.184 1.00 43.68  ? 181 ALA A O     1 
ATOM 977  C CB    . ALA A 1 181 ? 128.160 106.698 105.470 1.00 43.68  ? 181 ALA A CB    1 
ATOM 978  N N     . PHE A 1 182 ? 125.768 105.276 103.266 1.00 42.02  ? 182 PHE A N     1 
ATOM 979  C CA    . PHE A 1 182 ? 124.481 105.551 102.641 1.00 42.02  ? 182 PHE A CA    1 
ATOM 980  C C     . PHE A 1 182 ? 123.722 104.249 102.434 1.00 42.02  ? 182 PHE A C     1 
ATOM 981  O O     . PHE A 1 182 ? 124.301 103.250 101.997 1.00 42.02  ? 182 PHE A O     1 
ATOM 982  C CB    . PHE A 1 182 ? 124.656 106.279 101.305 1.00 42.02  ? 182 PHE A CB    1 
ATOM 983  C CG    . PHE A 1 182 ? 125.607 107.439 101.365 1.00 42.02  ? 182 PHE A CG    1 
ATOM 984  C CD1   . PHE A 1 182 ? 126.972 107.245 101.224 1.00 42.02  ? 182 PHE A CD1   1 
ATOM 985  C CD2   . PHE A 1 182 ? 125.138 108.721 101.579 1.00 42.02  ? 182 PHE A CD2   1 
ATOM 986  C CE1   . PHE A 1 182 ? 127.844 108.309 101.284 1.00 42.02  ? 182 PHE A CE1   1 
ATOM 987  C CE2   . PHE A 1 182 ? 126.006 109.787 101.642 1.00 42.02  ? 182 PHE A CE2   1 
ATOM 988  C CZ    . PHE A 1 182 ? 127.360 109.581 101.495 1.00 42.02  ? 182 PHE A CZ    1 
ATOM 989  N N     . GLY A 1 183 ? 122.427 104.269 102.741 1.00 43.28  ? 183 GLY A N     1 
ATOM 990  C CA    . GLY A 1 183 ? 121.590 103.101 102.610 1.00 43.28  ? 183 GLY A CA    1 
ATOM 991  C C     . GLY A 1 183 ? 121.296 102.755 101.166 1.00 43.28  ? 183 GLY A C     1 
ATOM 992  O O     . GLY A 1 183 ? 121.811 103.382 100.234 1.00 43.28  ? 183 GLY A O     1 
ATOM 993  N N     . PRO A 1 184 ? 120.464 101.732 100.953 1.00 43.11  ? 184 PRO A N     1 
ATOM 994  C CA    . PRO A 1 184 ? 120.144 101.322 99.577  1.00 43.11  ? 184 PRO A CA    1 
ATOM 995  C C     . PRO A 1 184 ? 119.514 102.422 98.744  1.00 43.11  ? 184 PRO A C     1 
ATOM 996  O O     . PRO A 1 184 ? 119.743 102.475 97.530  1.00 43.11  ? 184 PRO A O     1 
ATOM 997  C CB    . PRO A 1 184 ? 119.177 100.148 99.785  1.00 43.11  ? 184 PRO A CB    1 
ATOM 998  C CG    . PRO A 1 184 ? 119.532 99.616  101.136 1.00 43.11  ? 184 PRO A CG    1 
ATOM 999  C CD    . PRO A 1 184 ? 119.852 100.835 101.948 1.00 43.11  ? 184 PRO A CD    1 
ATOM 1000 N N     . ASP A 1 185 ? 118.729 103.305 99.357  1.00 44.75  ? 185 ASP A N     1 
ATOM 1001 C CA    . ASP A 1 185 ? 118.077 104.397 98.647  1.00 44.75  ? 185 ASP A CA    1 
ATOM 1002 C C     . ASP A 1 185 ? 118.990 105.597 98.446  1.00 44.75  ? 185 ASP A C     1 
ATOM 1003 O O     . ASP A 1 185 ? 118.577 106.574 97.814  1.00 44.75  ? 185 ASP A O     1 
ATOM 1004 C CB    . ASP A 1 185 ? 116.812 104.832 99.393  1.00 44.75  ? 185 ASP A CB    1 
ATOM 1005 C CG    . ASP A 1 185 ? 115.744 105.370 98.462  1.00 44.75  ? 185 ASP A CG    1 
ATOM 1006 O OD1   . ASP A 1 185 ? 115.790 105.051 97.255  1.00 44.75  ? 185 ASP A OD1   1 
ATOM 1007 O OD2   . ASP A 1 185 ? 114.858 106.111 98.936  1.00 44.75  ? 185 ASP A OD2   1 
ATOM 1008 N N     . GLY A 1 186 ? 120.214 105.550 98.967  1.00 42.51  ? 186 GLY A N     1 
ATOM 1009 C CA    . GLY A 1 186 ? 121.143 106.650 98.854  1.00 42.51  ? 186 GLY A CA    1 
ATOM 1010 C C     . GLY A 1 186 ? 121.138 107.614 100.019 1.00 42.51  ? 186 GLY A C     1 
ATOM 1011 O O     . GLY A 1 186 ? 122.082 108.403 100.152 1.00 42.51  ? 186 GLY A O     1 
ATOM 1012 N N     . LYS A 1 187 ? 120.113 107.579 100.866 1.00 39.95  ? 187 LYS A N     1 
ATOM 1013 C CA    . LYS A 1 187 ? 120.081 108.428 102.045 1.00 39.95  ? 187 LYS A CA    1 
ATOM 1014 C C     . LYS A 1 187 ? 121.088 107.934 103.074 1.00 39.95  ? 187 LYS A C     1 
ATOM 1015 O O     . LYS A 1 187 ? 121.397 106.742 103.150 1.00 39.95  ? 187 LYS A O     1 
ATOM 1016 C CB    . LYS A 1 187 ? 118.678 108.460 102.649 1.00 39.95  ? 187 LYS A CB    1 
ATOM 1017 C CG    . LYS A 1 187 ? 117.603 108.917 101.679 1.00 39.95  ? 187 LYS A CG    1 
ATOM 1018 C CD    . LYS A 1 187 ? 116.439 109.562 102.410 1.00 39.95  ? 187 LYS A CD    1 
ATOM 1019 C CE    . LYS A 1 187 ? 115.480 110.232 101.440 1.00 39.95  ? 187 LYS A CE    1 
ATOM 1020 N NZ    . LYS A 1 187 ? 116.083 111.439 100.810 1.00 39.95  ? 187 LYS A NZ    1 
ATOM 1021 N N     . LEU A 1 188 ? 121.626 108.874 103.847 1.00 40.04  ? 188 LEU A N     1 
ATOM 1022 C CA    . LEU A 1 188 ? 122.669 108.592 104.829 1.00 40.04  ? 188 LEU A CA    1 
ATOM 1023 C C     . LEU A 1 188 ? 122.166 107.577 105.851 1.00 40.04  ? 188 LEU A C     1 
ATOM 1024 O O     . LEU A 1 188 ? 121.013 107.644 106.272 1.00 40.04  ? 188 LEU A O     1 
ATOM 1025 C CB    . LEU A 1 188 ? 123.075 109.892 105.525 1.00 40.04  ? 188 LEU A CB    1 
ATOM 1026 C CG    . LEU A 1 188 ? 124.388 109.962 106.304 1.00 40.04  ? 188 LEU A CG    1 
ATOM 1027 C CD1   . LEU A 1 188 ? 125.564 109.676 105.386 1.00 40.04  ? 188 LEU A CD1   1 
ATOM 1028 C CD2   . LEU A 1 188 ? 124.533 111.346 106.912 1.00 40.04  ? 188 LEU A CD2   1 
ATOM 1029 N N     . LYS A 1 189 ? 123.015 106.631 106.248 1.00 40.94  ? 189 LYS A N     1 
ATOM 1030 C CA    . LYS A 1 189 ? 122.559 105.586 107.162 1.00 40.94  ? 189 LYS A CA    1 
ATOM 1031 C C     . LYS A 1 189 ? 122.364 106.115 108.576 1.00 40.94  ? 189 LYS A C     1 
ATOM 1032 O O     . LYS A 1 189 ? 121.269 106.008 109.140 1.00 40.94  ? 189 LYS A O     1 
ATOM 1033 C CB    . LYS A 1 189 ? 123.543 104.417 107.169 1.00 40.94  ? 189 LYS A CB    1 
ATOM 1034 C CG    . LYS A 1 189 ? 123.347 103.435 106.033 1.00 40.94  ? 189 LYS A CG    1 
ATOM 1035 C CD    . LYS A 1 189 ? 123.892 102.063 106.384 1.00 40.94  ? 189 LYS A CD    1 
ATOM 1036 C CE    . LYS A 1 189 ? 125.409 102.044 106.374 1.00 40.94  ? 189 LYS A CE    1 
ATOM 1037 N NZ    . LYS A 1 189 ? 125.944 100.676 106.614 1.00 40.94  ? 189 LYS A NZ    1 
ATOM 1038 N N     . GLU A 1 190 ? 123.409 106.688 109.168 1.00 44.16  ? 190 GLU A N     1 
ATOM 1039 C CA    . GLU A 1 190 ? 123.385 107.152 110.554 1.00 44.16  ? 190 GLU A CA    1 
ATOM 1040 C C     . GLU A 1 190 ? 123.121 108.653 110.538 1.00 44.16  ? 190 GLU A C     1 
ATOM 1041 O O     . GLU A 1 190 ? 124.033 109.459 110.727 1.00 44.16  ? 190 GLU A O     1 
ATOM 1042 C CB    . GLU A 1 190 ? 124.697 106.811 111.253 1.00 44.16  ? 190 GLU A CB    1 
ATOM 1043 C CG    . GLU A 1 190 ? 124.999 105.324 111.297 1.00 44.16  ? 190 GLU A CG    1 
ATOM 1044 C CD    . GLU A 1 190 ? 126.312 105.015 111.983 1.00 44.16  ? 190 GLU A CD    1 
ATOM 1045 O OE1   . GLU A 1 190 ? 127.041 105.967 112.333 1.00 44.16  ? 190 GLU A OE1   1 
ATOM 1046 O OE2   . GLU A 1 190 ? 126.618 103.819 112.172 1.00 44.16  ? 190 GLU A OE2   1 
ATOM 1047 N N     . ARG A 1 191 ? 121.859 109.020 110.331 1.00 39.94  ? 191 ARG A N     1 
ATOM 1048 C CA    . ARG A 1 191 ? 121.516 110.415 110.103 1.00 39.94  ? 191 ARG A CA    1 
ATOM 1049 C C     . ARG A 1 191 ? 121.739 111.233 111.373 1.00 39.94  ? 191 ARG A C     1 
ATOM 1050 O O     . ARG A 1 191 ? 121.248 110.865 112.445 1.00 39.94  ? 191 ARG A O     1 
ATOM 1051 C CB    . ARG A 1 191 ? 120.064 110.540 109.648 1.00 39.94  ? 191 ARG A CB    1 
ATOM 1052 C CG    . ARG A 1 191 ? 119.779 109.876 108.315 1.00 39.94  ? 191 ARG A CG    1 
ATOM 1053 C CD    . ARG A 1 191 ? 118.305 109.949 107.948 1.00 39.94  ? 191 ARG A CD    1 
ATOM 1054 N NE    . ARG A 1 191 ? 117.868 111.313 107.675 1.00 39.94  ? 191 ARG A NE    1 
ATOM 1055 C CZ    . ARG A 1 191 ? 117.050 112.006 108.454 1.00 39.94  ? 191 ARG A CZ    1 
ATOM 1056 N NH1   . ARG A 1 191 ? 116.556 111.494 109.569 1.00 39.94  ? 191 ARG A NH1   1 
ATOM 1057 N NH2   . ARG A 1 191 ? 116.718 113.246 108.105 1.00 39.94  ? 191 ARG A NH2   1 
ATOM 1058 N N     . PRO A 1 192 ? 122.490 112.330 111.288 1.00 37.22  ? 192 PRO A N     1 
ATOM 1059 C CA    . PRO A 1 192 ? 122.728 113.167 112.468 1.00 37.22  ? 192 PRO A CA    1 
ATOM 1060 C C     . PRO A 1 192 ? 121.431 113.688 113.068 1.00 37.22  ? 192 PRO A C     1 
ATOM 1061 O O     . PRO A 1 192 ? 120.346 113.585 112.494 1.00 37.22  ? 192 PRO A O     1 
ATOM 1062 C CB    . PRO A 1 192 ? 123.578 114.316 111.923 1.00 37.22  ? 192 PRO A CB    1 
ATOM 1063 C CG    . PRO A 1 192 ? 124.257 113.764 110.726 1.00 37.22  ? 192 PRO A CG    1 
ATOM 1064 C CD    . PRO A 1 192 ? 123.463 112.591 110.214 1.00 37.22  ? 192 PRO A CD    1 
ATOM 1065 N N     . GLY A 1 193 ? 121.566 114.269 114.253 1.00 36.42  ? 193 GLY A N     1 
ATOM 1066 C CA    . GLY A 1 193 ? 120.433 114.828 114.959 1.00 36.42  ? 193 GLY A CA    1 
ATOM 1067 C C     . GLY A 1 193 ? 120.511 116.338 115.005 1.00 36.42  ? 193 GLY A C     1 
ATOM 1068 O O     . GLY A 1 193 ? 121.552 116.939 114.741 1.00 36.42  ? 193 GLY A O     1 
ATOM 1069 N N     . ILE A 1 194 ? 119.378 116.950 115.349 1.00 34.11  ? 194 ILE A N     1 
ATOM 1070 C CA    . ILE A 1 194 ? 119.281 118.402 115.334 1.00 34.11  ? 194 ILE A CA    1 
ATOM 1071 C C     . ILE A 1 194 ? 120.061 118.987 116.500 1.00 34.11  ? 194 ILE A C     1 
ATOM 1072 O O     . ILE A 1 194 ? 119.857 118.608 117.658 1.00 34.11  ? 194 ILE A O     1 
ATOM 1073 C CB    . ILE A 1 194 ? 117.804 118.833 115.369 1.00 34.11  ? 194 ILE A CB    1 
ATOM 1074 C CG1   . ILE A 1 194 ? 117.008 118.069 114.311 1.00 34.11  ? 194 ILE A CG1   1 
ATOM 1075 C CG2   . ILE A 1 194 ? 117.675 120.332 115.166 1.00 34.11  ? 194 ILE A CG2   1 
ATOM 1076 C CD1   . ILE A 1 194 ? 117.435 118.373 112.895 1.00 34.11  ? 194 ILE A CD1   1 
ATOM 1077 N N     . ASN A 1 195 ? 120.962 119.914 116.194 1.00 34.12  ? 195 ASN A N     1 
ATOM 1078 C CA    . ASN A 1 195 ? 121.641 120.669 117.238 1.00 34.12  ? 195 ASN A CA    1 
ATOM 1079 C C     . ASN A 1 195 ? 120.746 121.809 117.710 1.00 34.12  ? 195 ASN A C     1 
ATOM 1080 O O     . ASN A 1 195 ? 120.387 122.680 116.909 1.00 34.12  ? 195 ASN A O     1 
ATOM 1081 C CB    . ASN A 1 195 ? 122.965 121.224 116.724 1.00 34.12  ? 195 ASN A CB    1 
ATOM 1082 C CG    . ASN A 1 195 ? 124.015 121.321 117.807 1.00 34.12  ? 195 ASN A CG    1 
ATOM 1083 O OD1   . ASN A 1 195 ? 123.724 121.133 118.988 1.00 34.12  ? 195 ASN A OD1   1 
ATOM 1084 N ND2   . ASN A 1 195 ? 125.247 121.617 117.412 1.00 34.12  ? 195 ASN A ND2   1 
ATOM 1085 N N     . PRO A 1 196 ? 120.363 121.843 118.984 1.00 34.13  ? 196 PRO A N     1 
ATOM 1086 C CA    . PRO A 1 196 ? 119.504 122.924 119.489 1.00 34.13  ? 196 PRO A CA    1 
ATOM 1087 C C     . PRO A 1 196 ? 120.237 124.206 119.859 1.00 34.13  ? 196 PRO A C     1 
ATOM 1088 O O     . PRO A 1 196 ? 119.582 125.160 120.288 1.00 34.13  ? 196 PRO A O     1 
ATOM 1089 C CB    . PRO A 1 196 ? 118.879 122.291 120.745 1.00 34.13  ? 196 PRO A CB    1 
ATOM 1090 C CG    . PRO A 1 196 ? 119.226 120.817 120.677 1.00 34.13  ? 196 PRO A CG    1 
ATOM 1091 C CD    . PRO A 1 196 ? 120.537 120.788 119.989 1.00 34.13  ? 196 PRO A CD    1 
ATOM 1092 N N     . SER A 1 197 ? 121.558 124.259 119.705 1.00 33.55  ? 197 SER A N     1 
ATOM 1093 C CA    . SER A 1 197 ? 122.329 125.412 120.148 1.00 33.55  ? 197 SER A CA    1 
ATOM 1094 C C     . SER A 1 197 ? 122.135 126.582 119.193 1.00 33.55  ? 197 SER A C     1 
ATOM 1095 O O     . SER A 1 197 ? 122.306 126.440 117.978 1.00 33.55  ? 197 SER A O     1 
ATOM 1096 C CB    . SER A 1 197 ? 123.810 125.053 120.247 1.00 33.55  ? 197 SER A CB    1 
ATOM 1097 O OG    . SER A 1 197 ? 124.031 124.058 121.230 1.00 33.55  ? 197 SER A OG    1 
ATOM 1098 N N     . ILE A 1 198 ? 121.781 127.741 119.746 1.00 32.78  ? 198 ILE A N     1 
ATOM 1099 C CA    . ILE A 1 198 ? 121.646 128.961 118.960 1.00 32.78  ? 198 ILE A CA    1 
ATOM 1100 C C     . ILE A 1 198 ? 122.962 129.726 119.010 1.00 32.78  ? 198 ILE A C     1 
ATOM 1101 O O     . ILE A 1 198 ? 123.209 130.502 119.941 1.00 32.78  ? 198 ILE A O     1 
ATOM 1102 C CB    . ILE A 1 198 ? 120.480 129.832 119.461 1.00 32.78  ? 198 ILE A CB    1 
ATOM 1103 C CG1   . ILE A 1 198 ? 119.156 129.088 119.305 1.00 32.78  ? 198 ILE A CG1   1 
ATOM 1104 C CG2   . ILE A 1 198 ? 120.422 131.133 118.687 1.00 32.78  ? 198 ILE A CG2   1 
ATOM 1105 C CD1   . ILE A 1 198 ? 117.997 129.763 120.001 1.00 32.78  ? 198 ILE A CD1   1 
ATOM 1106 N N     . TYR A 1 199 ? 123.821 129.497 118.022 1.00 33.86  ? 199 TYR A N     1 
ATOM 1107 C CA    . TYR A 1 199 ? 125.096 130.195 117.960 1.00 33.86  ? 199 TYR A CA    1 
ATOM 1108 C C     . TYR A 1 199 ? 124.871 131.663 117.619 1.00 33.86  ? 199 TYR A C     1 
ATOM 1109 O O     . TYR A 1 199 ? 124.056 131.991 116.751 1.00 33.86  ? 199 TYR A O     1 
ATOM 1110 C CB    . TYR A 1 199 ? 126.006 129.539 116.925 1.00 33.86  ? 199 TYR A CB    1 
ATOM 1111 C CG    . TYR A 1 199 ? 126.559 128.202 117.361 1.00 33.86  ? 199 TYR A CG    1 
ATOM 1112 C CD1   . TYR A 1 199 ? 127.739 128.118 118.083 1.00 33.86  ? 199 TYR A CD1   1 
ATOM 1113 C CD2   . TYR A 1 199 ? 125.898 127.023 117.048 1.00 33.86  ? 199 TYR A CD2   1 
ATOM 1114 C CE1   . TYR A 1 199 ? 128.246 126.897 118.481 1.00 33.86  ? 199 TYR A CE1   1 
ATOM 1115 C CE2   . TYR A 1 199 ? 126.397 125.798 117.441 1.00 33.86  ? 199 TYR A CE2   1 
ATOM 1116 C CZ    . TYR A 1 199 ? 127.572 125.741 118.157 1.00 33.86  ? 199 TYR A CZ    1 
ATOM 1117 O OH    . TYR A 1 199 ? 128.075 124.523 118.552 1.00 33.86  ? 199 TYR A OH    1 
ATOM 1118 N N     . CYS A 1 200 ? 125.594 132.545 118.299 1.00 36.85  ? 200 CYS A N     1 
ATOM 1119 C CA    . CYS A 1 200 ? 125.429 133.980 118.129 1.00 36.85  ? 200 CYS A CA    1 
ATOM 1120 C C     . CYS A 1 200 ? 126.450 134.535 117.143 1.00 36.85  ? 200 CYS A C     1 
ATOM 1121 O O     . CYS A 1 200 ? 127.484 133.923 116.863 1.00 36.85  ? 200 CYS A O     1 
ATOM 1122 C CB    . CYS A 1 200 ? 125.549 134.702 119.473 1.00 36.85  ? 200 CYS A CB    1 
ATOM 1123 S SG    . CYS A 1 200 ? 124.177 134.392 120.607 1.00 36.85  ? 200 CYS A SG    1 
ATOM 1124 N N     . TYR A 1 201 ? 126.142 135.721 116.623 1.00 35.01  ? 201 TYR A N     1 
ATOM 1125 C CA    . TYR A 1 201 ? 126.964 136.390 115.627 1.00 35.01  ? 201 TYR A CA    1 
ATOM 1126 C C     . TYR A 1 201 ? 127.285 137.797 116.119 1.00 35.01  ? 201 TYR A C     1 
ATOM 1127 O O     . TYR A 1 201 ? 126.839 138.219 117.188 1.00 35.01  ? 201 TYR A O     1 
ATOM 1128 C CB    . TYR A 1 201 ? 126.279 136.394 114.255 1.00 35.01  ? 201 TYR A CB    1 
ATOM 1129 C CG    . TYR A 1 201 ? 124.826 136.793 114.291 1.00 35.01  ? 201 TYR A CG    1 
ATOM 1130 C CD1   . TYR A 1 201 ? 123.842 135.862 114.586 1.00 35.01  ? 201 TYR A CD1   1 
ATOM 1131 C CD2   . TYR A 1 201 ? 124.434 138.092 114.016 1.00 35.01  ? 201 TYR A CD2   1 
ATOM 1132 C CE1   . TYR A 1 201 ? 122.518 136.216 114.624 1.00 35.01  ? 201 TYR A CE1   1 
ATOM 1133 C CE2   . TYR A 1 201 ? 123.104 138.451 114.044 1.00 35.01  ? 201 TYR A CE2   1 
ATOM 1134 C CZ    . TYR A 1 201 ? 122.150 137.510 114.348 1.00 35.01  ? 201 TYR A CZ    1 
ATOM 1135 O OH    . TYR A 1 201 ? 120.822 137.866 114.380 1.00 35.01  ? 201 TYR A OH    1 
ATOM 1136 N N     . GLN A 1 202 ? 128.084 138.519 115.327 1.00 36.09  ? 202 GLN A N     1 
ATOM 1137 C CA    . GLN A 1 202 ? 128.686 139.760 115.809 1.00 36.09  ? 202 GLN A CA    1 
ATOM 1138 C C     . GLN A 1 202 ? 127.643 140.825 116.119 1.00 36.09  ? 202 GLN A C     1 
ATOM 1139 O O     . GLN A 1 202 ? 127.662 141.423 117.201 1.00 36.09  ? 202 GLN A O     1 
ATOM 1140 C CB    . GLN A 1 202 ? 129.677 140.303 114.783 1.00 36.09  ? 202 GLN A CB    1 
ATOM 1141 C CG    . GLN A 1 202 ? 130.472 141.498 115.288 1.00 36.09  ? 202 GLN A CG    1 
ATOM 1142 C CD    . GLN A 1 202 ? 130.883 142.444 114.180 1.00 36.09  ? 202 GLN A CD    1 
ATOM 1143 O OE1   . GLN A 1 202 ? 131.930 142.274 113.557 1.00 36.09  ? 202 GLN A OE1   1 
ATOM 1144 N NE2   . GLN A 1 202 ? 130.059 143.453 113.931 1.00 36.09  ? 202 GLN A NE2   1 
ATOM 1145 N N     . GLN A 1 203 ? 126.731 141.087 115.182 1.00 36.50  ? 203 GLN A N     1 
ATOM 1146 C CA    . GLN A 1 203 ? 125.893 142.276 115.296 1.00 36.50  ? 203 GLN A CA    1 
ATOM 1147 C C     . GLN A 1 203 ? 124.879 142.135 116.422 1.00 36.50  ? 203 GLN A C     1 
ATOM 1148 O O     . GLN A 1 203 ? 124.204 143.105 116.786 1.00 36.50  ? 203 GLN A O     1 
ATOM 1149 C CB    . GLN A 1 203 ? 125.199 142.564 113.966 1.00 36.50  ? 203 GLN A CB    1 
ATOM 1150 C CG    . GLN A 1 203 ? 123.997 141.699 113.681 1.00 36.50  ? 203 GLN A CG    1 
ATOM 1151 C CD    . GLN A 1 203 ? 123.321 142.069 112.381 1.00 36.50  ? 203 GLN A CD    1 
ATOM 1152 O OE1   . GLN A 1 203 ? 123.798 142.933 111.647 1.00 36.50  ? 203 GLN A OE1   1 
ATOM 1153 N NE2   . GLN A 1 203 ? 122.197 141.423 112.092 1.00 36.50  ? 203 GLN A NE2   1 
ATOM 1154 N N     . VAL A 1 204 ? 124.773 140.923 116.956 1.00 35.47  ? 204 VAL A N     1 
ATOM 1155 C CA    . VAL A 1 204 ? 123.993 140.681 118.157 1.00 35.47  ? 204 VAL A CA    1 
ATOM 1156 C C     . VAL A 1 204 ? 124.876 140.098 119.257 1.00 35.47  ? 204 VAL A C     1 
ATOM 1157 O O     . VAL A 1 204 ? 125.096 138.888 119.336 1.00 35.47  ? 204 VAL A O     1 
ATOM 1158 C CB    . VAL A 1 204 ? 122.798 139.754 117.897 1.00 35.47  ? 204 VAL A CB    1 
ATOM 1159 C CG1   . VAL A 1 204 ? 122.031 139.565 119.185 1.00 35.47  ? 204 VAL A CG1   1 
ATOM 1160 C CG2   . VAL A 1 204 ? 121.882 140.351 116.841 1.00 35.47  ? 204 VAL A CG2   1 
ATOM 1161 N N     . SER A 1 205 ? 125.390 140.984 120.099 1.00 35.89  ? 205 SER A N     1 
ATOM 1162 C CA    . SER A 1 205 ? 126.295 140.604 121.171 1.00 35.89  ? 205 SER A CA    1 
ATOM 1163 C C     . SER A 1 205 ? 125.774 141.201 122.467 1.00 35.89  ? 205 SER A C     1 
ATOM 1164 O O     . SER A 1 205 ? 125.040 142.196 122.446 1.00 35.89  ? 205 SER A O     1 
ATOM 1165 C CB    . SER A 1 205 ? 127.724 141.091 120.895 1.00 35.89  ? 205 SER A CB    1 
ATOM 1166 O OG    . SER A 1 205 ? 128.285 140.420 119.782 1.00 35.89  ? 205 SER A OG    1 
ATOM 1167 N N     . PRO A 1 206 ? 126.117 140.608 123.610 1.00 35.54  ? 206 PRO A N     1 
ATOM 1168 C CA    . PRO A 1 206 ? 125.653 141.160 124.885 1.00 35.54  ? 206 PRO A CA    1 
ATOM 1169 C C     . PRO A 1 206 ? 126.153 142.578 125.107 1.00 35.54  ? 206 PRO A C     1 
ATOM 1170 O O     . PRO A 1 206 ? 127.301 142.917 124.812 1.00 35.54  ? 206 PRO A O     1 
ATOM 1171 C CB    . PRO A 1 206 ? 126.240 140.194 125.921 1.00 35.54  ? 206 PRO A CB    1 
ATOM 1172 C CG    . PRO A 1 206 ? 127.412 139.576 125.227 1.00 35.54  ? 206 PRO A CG    1 
ATOM 1173 C CD    . PRO A 1 206 ? 126.953 139.413 123.813 1.00 35.54  ? 206 PRO A CD    1 
ATOM 1174 N N     . VAL A 1 207 ? 125.261 143.411 125.633 1.00 36.00  ? 207 VAL A N     1 
ATOM 1175 C CA    . VAL A 1 207 ? 125.571 144.796 125.972 1.00 36.00  ? 207 VAL A CA    1 
ATOM 1176 C C     . VAL A 1 207 ? 124.945 145.097 127.328 1.00 36.00  ? 207 VAL A C     1 
ATOM 1177 O O     . VAL A 1 207 ? 123.982 144.425 127.724 1.00 36.00  ? 207 VAL A O     1 
ATOM 1178 C CB    . VAL A 1 207 ? 125.070 145.768 124.891 1.00 36.00  ? 207 VAL A CB    1 
ATOM 1179 C CG1   . VAL A 1 207 ? 125.899 145.637 123.625 1.00 36.00  ? 207 VAL A CG1   1 
ATOM 1180 C CG2   . VAL A 1 207 ? 123.603 145.517 124.593 1.00 36.00  ? 207 VAL A CG2   1 
ATOM 1181 N N     . PRO A 1 208 ? 125.464 146.069 128.079 1.00 37.09  ? 208 PRO A N     1 
ATOM 1182 C CA    . PRO A 1 208 ? 124.842 146.419 129.360 1.00 37.09  ? 208 PRO A CA    1 
ATOM 1183 C C     . PRO A 1 208 ? 123.397 146.859 129.185 1.00 37.09  ? 208 PRO A C     1 
ATOM 1184 O O     . PRO A 1 208 ? 123.030 147.495 128.195 1.00 37.09  ? 208 PRO A O     1 
ATOM 1185 C CB    . PRO A 1 208 ? 125.713 147.567 129.876 1.00 37.09  ? 208 PRO A CB    1 
ATOM 1186 C CG    . PRO A 1 208 ? 127.021 147.389 129.204 1.00 37.09  ? 208 PRO A CG    1 
ATOM 1187 C CD    . PRO A 1 208 ? 126.761 146.737 127.883 1.00 37.09  ? 208 PRO A CD    1 
ATOM 1188 N N     . TYR A 1 209 ? 122.573 146.506 130.167 1.00 39.06  ? 209 TYR A N     1 
ATOM 1189 C CA    . TYR A 1 209 ? 121.165 146.871 130.135 1.00 39.06  ? 209 TYR A CA    1 
ATOM 1190 C C     . TYR A 1 209 ? 120.988 148.360 130.412 1.00 39.06  ? 209 TYR A C     1 
ATOM 1191 O O     . TYR A 1 209 ? 121.614 148.919 131.316 1.00 39.06  ? 209 TYR A O     1 
ATOM 1192 C CB    . TYR A 1 209 ? 120.385 146.043 131.157 1.00 39.06  ? 209 TYR A CB    1 
ATOM 1193 C CG    . TYR A 1 209 ? 118.904 146.345 131.209 1.00 39.06  ? 209 TYR A CG    1 
ATOM 1194 C CD1   . TYR A 1 209 ? 118.402 147.320 132.059 1.00 39.06  ? 209 TYR A CD1   1 
ATOM 1195 C CD2   . TYR A 1 209 ? 118.010 145.652 130.408 1.00 39.06  ? 209 TYR A CD2   1 
ATOM 1196 C CE1   . TYR A 1 209 ? 117.051 147.598 132.107 1.00 39.06  ? 209 TYR A CE1   1 
ATOM 1197 C CE2   . TYR A 1 209 ? 116.658 145.922 130.450 1.00 39.06  ? 209 TYR A CE2   1 
ATOM 1198 C CZ    . TYR A 1 209 ? 116.184 146.895 131.301 1.00 39.06  ? 209 TYR A CZ    1 
ATOM 1199 O OH    . TYR A 1 209 ? 114.837 147.169 131.347 1.00 39.06  ? 209 TYR A OH    1 
ATOM 1200 N N     . ASN A 1 210 ? 120.126 149.000 129.623 1.00 40.46  ? 210 ASN A N     1 
ATOM 1201 C CA    . ASN A 1 210 ? 119.788 150.404 129.785 1.00 40.46  ? 210 ASN A CA    1 
ATOM 1202 C C     . ASN A 1 210 ? 118.277 150.554 129.893 1.00 40.46  ? 210 ASN A C     1 
ATOM 1203 O O     . ASN A 1 210 ? 117.544 150.127 128.993 1.00 40.46  ? 210 ASN A O     1 
ATOM 1204 C CB    . ASN A 1 210 ? 120.306 151.244 128.610 1.00 40.46  ? 210 ASN A CB    1 
ATOM 1205 C CG    . ASN A 1 210 ? 121.797 151.074 128.382 1.00 40.46  ? 210 ASN A CG    1 
ATOM 1206 O OD1   . ASN A 1 210 ? 122.548 150.765 129.307 1.00 40.46  ? 210 ASN A OD1   1 
ATOM 1207 N ND2   . ASN A 1 210 ? 122.232 151.278 127.144 1.00 40.46  ? 210 ASN A ND2   1 
ATOM 1208 N N     . PRO A 1 211 ? 117.783 151.148 130.981 1.00 42.92  ? 211 PRO A N     1 
ATOM 1209 C CA    . PRO A 1 211 ? 116.323 151.285 131.135 1.00 42.92  ? 211 PRO A CA    1 
ATOM 1210 C C     . PRO A 1 211 ? 115.672 152.151 130.070 1.00 42.92  ? 211 PRO A C     1 
ATOM 1211 O O     . PRO A 1 211 ? 114.456 152.057 129.861 1.00 42.92  ? 211 PRO A O     1 
ATOM 1212 C CB    . PRO A 1 211 ? 116.179 151.902 132.534 1.00 42.92  ? 211 PRO A CB    1 
ATOM 1213 C CG    . PRO A 1 211 ? 117.445 151.543 133.244 1.00 42.92  ? 211 PRO A CG    1 
ATOM 1214 C CD    . PRO A 1 211 ? 118.511 151.561 132.191 1.00 42.92  ? 211 PRO A CD    1 
ATOM 1215 N N     . ALA A 1 212 ? 116.444 153.000 129.388 1.00 43.16  ? 212 ALA A N     1 
ATOM 1216 C CA    . ALA A 1 212 ? 115.847 153.935 128.440 1.00 43.16  ? 212 ALA A CA    1 
ATOM 1217 C C     . ALA A 1 212 ? 115.603 153.285 127.082 1.00 43.16  ? 212 ALA A C     1 
ATOM 1218 O O     . ALA A 1 212 ? 114.461 153.231 126.612 1.00 43.16  ? 212 ALA A O     1 
ATOM 1219 C CB    . ALA A 1 212 ? 116.737 155.169 128.291 1.00 43.16  ? 212 ALA A CB    1 
ATOM 1220 N N     . LYS A 1 213 ? 116.658 152.787 126.437 1.00 41.84  ? 213 LYS A N     1 
ATOM 1221 C CA    . LYS A 1 213 ? 116.541 152.267 125.080 1.00 41.84  ? 213 LYS A CA    1 
ATOM 1222 C C     . LYS A 1 213 ? 116.006 150.841 125.089 1.00 41.84  ? 213 LYS A C     1 
ATOM 1223 O O     . LYS A 1 213 ? 115.034 150.532 124.393 1.00 41.84  ? 213 LYS A O     1 
ATOM 1224 C CB    . LYS A 1 213 ? 117.897 152.337 124.368 1.00 41.84  ? 213 LYS A CB    1 
ATOM 1225 C CG    . LYS A 1 213 ? 117.873 151.987 122.880 1.00 41.84  ? 213 LYS A CG    1 
ATOM 1226 C CD    . LYS A 1 213 ? 118.130 150.508 122.622 1.00 41.84  ? 213 LYS A CD    1 
ATOM 1227 C CE    . LYS A 1 213 ? 118.175 150.209 121.132 1.00 41.84  ? 213 LYS A CE    1 
ATOM 1228 N NZ    . LYS A 1 213 ? 118.389 148.761 120.861 1.00 41.84  ? 213 LYS A NZ    1 
ATOM 1229 N N     . HIS A 1 214 ? 116.635 149.971 125.867 1.00 39.85  ? 214 HIS A N     1 
ATOM 1230 C CA    . HIS A 1 214 ? 116.199 148.588 125.952 1.00 39.85  ? 214 HIS A CA    1 
ATOM 1231 C C     . HIS A 1 214 ? 114.815 148.524 126.598 1.00 39.85  ? 214 HIS A C     1 
ATOM 1232 O O     . HIS A 1 214 ? 114.454 149.430 127.362 1.00 39.85  ? 214 HIS A O     1 
ATOM 1233 C CB    . HIS A 1 214 ? 117.218 147.774 126.751 1.00 39.85  ? 214 HIS A CB    1 
ATOM 1234 C CG    . HIS A 1 214 ? 118.572 147.725 126.116 1.00 39.85  ? 214 HIS A CG    1 
ATOM 1235 N ND1   . HIS A 1 214 ? 119.720 147.444 126.824 1.00 39.85  ? 214 HIS A ND1   1 
ATOM 1236 C CD2   . HIS A 1 214 ? 118.960 147.926 124.835 1.00 39.85  ? 214 HIS A CD2   1 
ATOM 1237 C CE1   . HIS A 1 214 ? 120.758 147.477 126.007 1.00 39.85  ? 214 HIS A CE1   1 
ATOM 1238 N NE2   . HIS A 1 214 ? 120.324 147.764 124.794 1.00 39.85  ? 214 HIS A NE2   1 
ATOM 1239 N N     . PRO A 1 215 ? 114.016 147.493 126.315 1.00 39.58  ? 215 PRO A N     1 
ATOM 1240 C CA    . PRO A 1 215 ? 112.612 147.510 126.737 1.00 39.58  ? 215 PRO A CA    1 
ATOM 1241 C C     . PRO A 1 215 ? 112.463 147.549 128.250 1.00 39.58  ? 215 PRO A C     1 
ATOM 1242 O O     . PRO A 1 215 ? 113.314 147.068 129.002 1.00 39.58  ? 215 PRO A O     1 
ATOM 1243 C CB    . PRO A 1 215 ? 112.057 146.204 126.159 1.00 39.58  ? 215 PRO A CB    1 
ATOM 1244 C CG    . PRO A 1 215 ? 113.248 145.312 126.093 1.00 39.58  ? 215 PRO A CG    1 
ATOM 1245 C CD    . PRO A 1 215 ? 114.363 146.220 125.660 1.00 39.58  ? 215 PRO A CD    1 
ATOM 1246 N N     . ALA A 1 216 ? 111.358 148.150 128.689 1.00 41.35  ? 216 ALA A N     1 
ATOM 1247 C CA    . ALA A 1 216 ? 111.069 148.242 130.112 1.00 41.35  ? 216 ALA A CA    1 
ATOM 1248 C C     . ALA A 1 216 ? 110.947 146.852 130.722 1.00 41.35  ? 216 ALA A C     1 
ATOM 1249 O O     . ALA A 1 216 ? 110.295 145.963 130.168 1.00 41.35  ? 216 ALA A O     1 
ATOM 1250 C CB    . ALA A 1 216 ? 109.784 149.037 130.342 1.00 41.35  ? 216 ALA A CB    1 
ATOM 1251 N N     . LEU A 1 217 ? 111.609 146.692 131.865 1.00 42.37  ? 217 LEU A N     1 
ATOM 1252 C CA    . LEU A 1 217 ? 111.814 145.396 132.487 1.00 42.37  ? 217 LEU A CA    1 
ATOM 1253 C C     . LEU A 1 217 ? 112.122 145.554 134.000 1.00 42.37  ? 217 LEU A C     1 
ATOM 1254 O O     . LEU A 1 217 ? 113.003 146.339 134.351 1.00 42.37  ? 217 LEU A O     1 
ATOM 1255 C CB    . LEU A 1 217 ? 112.943 144.646 131.784 1.00 42.37  ? 217 LEU A CB    1 
ATOM 1256 C CG    . LEU A 1 217 ? 113.134 143.162 132.078 1.00 42.37  ? 217 LEU A CG    1 
ATOM 1257 C CD1   . LEU A 1 217 ? 111.907 142.371 131.655 1.00 42.37  ? 217 LEU A CD1   1 
ATOM 1258 C CD2   . LEU A 1 217 ? 114.361 142.676 131.333 1.00 42.37  ? 217 LEU A CD2   1 
ATOM 1259 N N     . PRO A 1 218 ? 111.404 144.822 134.901 1.00 44.96  ? 218 PRO A N     1 
ATOM 1260 C CA    . PRO A 1 218 ? 111.718 145.025 136.321 1.00 44.96  ? 218 PRO A CA    1 
ATOM 1261 C C     . PRO A 1 218 ? 113.104 144.510 136.679 1.00 44.96  ? 218 PRO A C     1 
ATOM 1262 O O     . PRO A 1 218 ? 113.321 143.305 136.841 1.00 44.96  ? 218 PRO A O     1 
ATOM 1263 C CB    . PRO A 1 218 ? 110.610 144.251 137.044 1.00 44.96  ? 218 PRO A CB    1 
ATOM 1264 C CG    . PRO A 1 218 ? 110.180 143.210 136.081 1.00 44.96  ? 218 PRO A CG    1 
ATOM 1265 C CD    . PRO A 1 218 ? 110.388 143.776 134.698 1.00 44.96  ? 218 PRO A CD    1 
ATOM 1266 N N     . PHE A 1 219 ? 114.039 145.447 136.837 1.00 44.42  ? 219 PHE A N     1 
ATOM 1267 C CA    . PHE A 1 219 ? 115.442 145.160 137.109 1.00 44.42  ? 219 PHE A CA    1 
ATOM 1268 C C     . PHE A 1 219 ? 116.148 146.422 137.580 1.00 44.42  ? 219 PHE A C     1 
ATOM 1269 O O     . PHE A 1 219 ? 115.509 147.453 137.812 1.00 44.42  ? 219 PHE A O     1 
ATOM 1270 C CB    . PHE A 1 219 ? 116.153 144.617 135.866 1.00 44.42  ? 219 PHE A CB    1 
ATOM 1271 C CG    . PHE A 1 219 ? 116.201 143.119 135.792 1.00 44.42  ? 219 PHE A CG    1 
ATOM 1272 C CD1   . PHE A 1 219 ? 117.038 142.398 136.628 1.00 44.42  ? 219 PHE A CD1   1 
ATOM 1273 C CD2   . PHE A 1 219 ? 115.439 142.434 134.865 1.00 44.42  ? 219 PHE A CD2   1 
ATOM 1274 C CE1   . PHE A 1 219 ? 117.096 141.022 136.551 1.00 44.42  ? 219 PHE A CE1   1 
ATOM 1275 C CE2   . PHE A 1 219 ? 115.491 141.059 134.783 1.00 44.42  ? 219 PHE A CE2   1 
ATOM 1276 C CZ    . PHE A 1 219 ? 116.320 140.352 135.626 1.00 44.42  ? 219 PHE A CZ    1 
ATOM 1277 N N     . SER A 1 220 ? 117.467 146.350 137.717 1.00 47.08  ? 220 SER A N     1 
ATOM 1278 C CA    . SER A 1 220 ? 118.291 147.515 137.988 1.00 47.08  ? 220 SER A CA    1 
ATOM 1279 C C     . SER A 1 220 ? 119.383 147.605 136.934 1.00 47.08  ? 220 SER A C     1 
ATOM 1280 O O     . SER A 1 220 ? 120.042 146.616 136.606 1.00 47.08  ? 220 SER A O     1 
ATOM 1281 C CB    . SER A 1 220 ? 118.911 147.461 139.392 1.00 47.08  ? 220 SER A CB    1 
ATOM 1282 O OG    . SER A 1 220 ? 119.765 148.569 139.615 1.00 47.08  ? 220 SER A OG    1 
ATOM 1283 N N     . GLY A 1 221 ? 119.570 148.812 136.402 1.00 49.54  ? 221 GLY A N     1 
ATOM 1284 C CA    . GLY A 1 221 ? 120.559 149.038 135.376 1.00 49.54  ? 221 GLY A CA    1 
ATOM 1285 C C     . GLY A 1 221 ? 121.827 149.623 135.965 1.00 49.54  ? 221 GLY A C     1 
ATOM 1286 O O     . GLY A 1 221 ? 121.795 150.483 136.846 1.00 49.54  ? 221 GLY A O     1 
ATOM 1287 N N     . VAL A 1 222 ? 122.955 149.135 135.457 1.00 52.26  ? 222 VAL A N     1 
ATOM 1288 C CA    . VAL A 1 222 ? 124.274 149.556 135.909 1.00 52.26  ? 222 VAL A CA    1 
ATOM 1289 C C     . VAL A 1 222 ? 124.992 150.228 134.747 1.00 52.26  ? 222 VAL A C     1 
ATOM 1290 O O     . VAL A 1 222 ? 125.049 149.681 133.640 1.00 52.26  ? 222 VAL A O     1 
ATOM 1291 C CB    . VAL A 1 222 ? 125.090 148.373 136.467 1.00 52.26  ? 222 VAL A CB    1 
ATOM 1292 C CG1   . VAL A 1 222 ? 124.478 147.883 137.768 1.00 52.26  ? 222 VAL A CG1   1 
ATOM 1293 C CG2   . VAL A 1 222 ? 125.144 147.232 135.466 1.00 52.26  ? 222 VAL A CG2   1 
ATOM 1294 N N     . ASP A 1 223 ? 125.522 151.417 135.018 1.00 52.32  ? 223 ASP A N     1 
ATOM 1295 C CA    . ASP A 1 223 ? 126.327 152.168 134.067 1.00 52.32  ? 223 ASP A CA    1 
ATOM 1296 C C     . ASP A 1 223 ? 127.667 151.477 133.875 1.00 52.32  ? 223 ASP A C     1 
ATOM 1297 O O     . ASP A 1 223 ? 128.353 151.172 134.849 1.00 52.32  ? 223 ASP A O     1 
ATOM 1298 C CB    . ASP A 1 223 ? 126.546 153.590 134.590 1.00 52.32  ? 223 ASP A CB    1 
ATOM 1299 C CG    . ASP A 1 223 ? 127.340 154.455 133.630 1.00 52.32  ? 223 ASP A CG    1 
ATOM 1300 O OD1   . ASP A 1 223 ? 127.026 154.457 132.422 1.00 52.32  ? 223 ASP A OD1   1 
ATOM 1301 O OD2   . ASP A 1 223 ? 128.271 155.148 134.090 1.00 52.32  ? 223 ASP A OD2   1 
ATOM 1302 N N     . PRO A 1 224 ? 128.040 151.219 132.613 1.00 50.10  ? 224 PRO A N     1 
ATOM 1303 C CA    . PRO A 1 224 ? 129.381 150.727 132.300 1.00 50.10  ? 224 PRO A CA    1 
ATOM 1304 C C     . PRO A 1 224 ? 130.456 151.494 133.065 1.00 50.10  ? 224 PRO A C     1 
ATOM 1305 O O     . PRO A 1 224 ? 131.342 150.865 133.638 1.00 50.10  ? 224 PRO A O     1 
ATOM 1306 C CB    . PRO A 1 224 ? 129.508 151.006 130.805 1.00 50.10  ? 224 PRO A CB    1 
ATOM 1307 C CG    . PRO A 1 224 ? 128.111 150.916 130.291 1.00 50.10  ? 224 PRO A CG    1 
ATOM 1308 C CD    . PRO A 1 224 ? 127.178 151.269 131.418 1.00 50.10  ? 224 PRO A CD    1 
ATOM 1309 N N     . GLY A 1 225 ? 130.376 152.824 133.078 1.00 50.50  ? 225 GLY A N     1 
ATOM 1310 C CA    . GLY A 1 225 ? 131.427 153.629 133.677 1.00 50.50  ? 225 GLY A CA    1 
ATOM 1311 C C     . GLY A 1 225 ? 131.685 153.277 135.129 1.00 50.50  ? 225 GLY A C     1 
ATOM 1312 O O     . GLY A 1 225 ? 132.836 153.231 135.571 1.00 50.50  ? 225 GLY A O     1 
ATOM 1313 N N     . ALA A 1 226 ? 130.627 153.027 135.887 1.00 50.25  ? 226 ALA A N     1 
ATOM 1314 C CA    . ALA A 1 226 ? 130.784 152.702 137.299 1.00 50.25  ? 226 ALA A CA    1 
ATOM 1315 C C     . ALA A 1 226 ? 131.344 151.293 137.451 1.00 50.25  ? 226 ALA A C     1 
ATOM 1316 O O     . ALA A 1 226 ? 130.759 150.340 136.923 1.00 50.25  ? 226 ALA A O     1 
ATOM 1317 C CB    . ALA A 1 226 ? 129.449 152.822 138.027 1.00 50.25  ? 226 ALA A CB    1 
ATOM 1318 N N     . PRO A 1 227 ? 132.471 151.119 138.141 1.00 47.87  ? 227 PRO A N     1 
ATOM 1319 C CA    . PRO A 1 227 ? 133.010 149.769 138.352 1.00 47.87  ? 227 PRO A CA    1 
ATOM 1320 C C     . PRO A 1 227 ? 132.032 148.907 139.137 1.00 47.87  ? 227 PRO A C     1 
ATOM 1321 O O     . PRO A 1 227 ? 131.293 149.402 139.990 1.00 47.87  ? 227 PRO A O     1 
ATOM 1322 C CB    . PRO A 1 227 ? 134.298 150.027 139.142 1.00 47.87  ? 227 PRO A CB    1 
ATOM 1323 C CG    . PRO A 1 227 ? 134.707 151.398 138.702 1.00 47.87  ? 227 PRO A CG    1 
ATOM 1324 C CD    . PRO A 1 227 ? 133.405 152.152 138.621 1.00 47.87  ? 227 PRO A CD    1 
ATOM 1325 N N     . LEU A 1 228 ? 132.026 147.614 138.832 1.00 45.28  ? 228 LEU A N     1 
ATOM 1326 C CA    . LEU A 1 228 ? 131.133 146.695 139.520 1.00 45.28  ? 228 LEU A CA    1 
ATOM 1327 C C     . LEU A 1 228 ? 131.491 146.643 141.002 1.00 45.28  ? 228 LEU A C     1 
ATOM 1328 O O     . LEU A 1 228 ? 132.669 146.471 141.344 1.00 45.28  ? 228 LEU A O     1 
ATOM 1329 C CB    . LEU A 1 228 ? 131.221 145.301 138.903 1.00 45.28  ? 228 LEU A CB    1 
ATOM 1330 C CG    . LEU A 1 228 ? 130.618 145.147 137.507 1.00 45.28  ? 228 LEU A CG    1 
ATOM 1331 C CD1   . LEU A 1 228 ? 130.739 143.710 137.030 1.00 45.28  ? 228 LEU A CD1   1 
ATOM 1332 C CD2   . LEU A 1 228 ? 129.168 145.598 137.502 1.00 45.28  ? 228 LEU A CD2   1 
ATOM 1333 N N     . PRO A 1 229 ? 130.522 146.790 141.901 1.00 44.67  ? 229 PRO A N     1 
ATOM 1334 C CA    . PRO A 1 229 ? 130.838 146.845 143.333 1.00 44.67  ? 229 PRO A CA    1 
ATOM 1335 C C     . PRO A 1 229 ? 131.339 145.503 143.844 1.00 44.67  ? 229 PRO A C     1 
ATOM 1336 O O     . PRO A 1 229 ? 131.065 144.440 143.283 1.00 44.67  ? 229 PRO A O     1 
ATOM 1337 C CB    . PRO A 1 229 ? 129.514 147.232 144.000 1.00 44.67  ? 229 PRO A CB    1 
ATOM 1338 C CG    . PRO A 1 229 ? 128.463 147.089 142.966 1.00 44.67  ? 229 PRO A CG    1 
ATOM 1339 C CD    . PRO A 1 229 ? 129.082 146.911 141.620 1.00 44.67  ? 229 PRO A CD    1 
ATOM 1340 N N     . LEU A 1 230 ? 132.095 145.572 144.937 1.00 44.77  ? 230 LEU A N     1 
ATOM 1341 C CA    . LEU A 1 230 ? 132.644 144.398 145.607 1.00 44.77  ? 230 LEU A CA    1 
ATOM 1342 C C     . LEU A 1 230 ? 131.719 144.058 146.767 1.00 44.77  ? 230 LEU A C     1 
ATOM 1343 O O     . LEU A 1 230 ? 131.698 144.766 147.781 1.00 44.77  ? 230 LEU A O     1 
ATOM 1344 C CB    . LEU A 1 230 ? 134.069 144.657 146.089 1.00 44.77  ? 230 LEU A CB    1 
ATOM 1345 C CG    . LEU A 1 230 ? 134.796 143.487 146.754 1.00 44.77  ? 230 LEU A CG    1 
ATOM 1346 C CD1   . LEU A 1 230 ? 134.966 142.341 145.771 1.00 44.77  ? 230 LEU A CD1   1 
ATOM 1347 C CD2   . LEU A 1 230 ? 136.142 143.932 147.296 1.00 44.77  ? 230 LEU A CD2   1 
ATOM 1348 N N     . GLY A 1 231 ? 130.959 142.979 146.619 1.00 46.01  ? 231 GLY A N     1 
ATOM 1349 C CA    . GLY A 1 231 ? 129.949 142.654 147.600 1.00 46.01  ? 231 GLY A CA    1 
ATOM 1350 C C     . GLY A 1 231 ? 130.535 142.129 148.895 1.00 46.01  ? 231 GLY A C     1 
ATOM 1351 O O     . GLY A 1 231 ? 131.712 141.777 148.989 1.00 46.01  ? 231 GLY A O     1 
ATOM 1352 N N     . THR A 1 232 ? 129.677 142.084 149.913 1.00 48.86  ? 232 THR A N     1 
ATOM 1353 C CA    . THR A 1 232 ? 130.057 141.734 151.287 1.00 48.86  ? 232 THR A CA    1 
ATOM 1354 C C     . THR A 1 232 ? 131.538 141.937 151.611 1.00 48.86  ? 232 THR A C     1 
ATOM 1355 O O     . THR A 1 232 ? 132.262 140.967 151.833 1.00 48.86  ? 232 THR A O     1 
ATOM 1356 C CB    . THR A 1 232 ? 129.664 140.281 151.628 1.00 48.86  ? 232 THR A CB    1 
ATOM 1357 O OG1   . THR A 1 232 ? 130.136 139.398 150.603 1.00 48.86  ? 232 THR A OG1   1 
ATOM 1358 C CG2   . THR A 1 232 ? 128.156 140.150 151.740 1.00 48.86  ? 232 THR A CG2   1 
ATOM 1359 N N     . PRO A 1 233 ? 131.990 143.202 151.654 1.00 50.45  ? 233 PRO A N     1 
ATOM 1360 C CA    . PRO A 1 233 ? 133.412 143.441 151.921 1.00 50.45  ? 233 PRO A CA    1 
ATOM 1361 C C     . PRO A 1 233 ? 133.762 142.973 153.324 1.00 50.45  ? 233 PRO A C     1 
ATOM 1362 O O     . PRO A 1 233 ? 134.658 142.150 153.513 1.00 50.45  ? 233 PRO A O     1 
ATOM 1363 C CB    . PRO A 1 233 ? 133.541 144.968 151.831 1.00 50.45  ? 233 PRO A CB    1 
ATOM 1364 C CG    . PRO A 1 233 ? 132.285 145.447 151.177 1.00 50.45  ? 233 PRO A CG    1 
ATOM 1365 C CD    . PRO A 1 233 ? 131.230 144.459 151.562 1.00 50.45  ? 233 PRO A CD    1 
ATOM 1366 N N     . ASN A 1 234 ? 133.037 143.503 154.300 1.00 51.28  ? 234 ASN A N     1 
ATOM 1367 C CA    . ASN A 1 234 ? 133.088 143.012 155.666 1.00 51.28  ? 234 ASN A CA    1 
ATOM 1368 C C     . ASN A 1 234 ? 132.075 141.893 155.874 1.00 51.28  ? 234 ASN A C     1 
ATOM 1369 O O     . ASN A 1 234 ? 131.185 141.683 155.050 1.00 51.28  ? 234 ASN A O     1 
ATOM 1370 C CB    . ASN A 1 234 ? 132.841 144.158 156.646 1.00 51.28  ? 234 ASN A CB    1 
ATOM 1371 C CG    . ASN A 1 234 ? 131.852 145.181 156.115 1.00 51.28  ? 234 ASN A CG    1 
ATOM 1372 O OD1   . ASN A 1 234 ? 130.877 144.840 155.444 1.00 51.28  ? 234 ASN A OD1   1 
ATOM 1373 N ND2   . ASN A 1 234 ? 132.093 146.448 156.431 1.00 51.28  ? 234 ASN A ND2   1 
ATOM 1374 N N     . ARG A 1 235 ? 132.214 141.179 156.987 1.00 48.97  ? 235 ARG A N     1 
ATOM 1375 C CA    . ARG A 1 235 ? 131.417 139.987 157.246 1.00 48.97  ? 235 ARG A CA    1 
ATOM 1376 C C     . ARG A 1 235 ? 130.725 140.081 158.602 1.00 48.97  ? 235 ARG A C     1 
ATOM 1377 O O     . ARG A 1 235 ? 129.601 139.612 158.776 1.00 48.97  ? 235 ARG A O     1 
ATOM 1378 C CB    . ARG A 1 235 ? 132.312 138.745 157.197 1.00 48.97  ? 235 ARG A CB    1 
ATOM 1379 C CG    . ARG A 1 235 ? 131.569 137.420 157.257 1.00 48.97  ? 235 ARG A CG    1 
ATOM 1380 C CD    . ARG A 1 235 ? 132.518 136.264 157.536 1.00 48.97  ? 235 ARG A CD    1 
ATOM 1381 N NE    . ARG A 1 235 ? 133.497 136.075 156.469 1.00 48.97  ? 235 ARG A NE    1 
ATOM 1382 C CZ    . ARG A 1 235 ? 133.365 135.201 155.476 1.00 48.97  ? 235 ARG A CZ    1 
ATOM 1383 N NH1   . ARG A 1 235 ? 132.294 134.423 155.409 1.00 48.97  ? 235 ARG A NH1   1 
ATOM 1384 N NH2   . ARG A 1 235 ? 134.309 135.101 154.550 1.00 48.97  ? 235 ARG A NH2   1 
ATOM 1385 N N     . LEU A 1 236 ? 131.407 140.697 159.562 1.00 50.62  ? 236 LEU A N     1 
ATOM 1386 C CA    . LEU A 1 236 ? 130.999 140.622 160.959 1.00 50.62  ? 236 LEU A CA    1 
ATOM 1387 C C     . LEU A 1 236 ? 130.443 141.950 161.463 1.00 50.62  ? 236 LEU A C     1 
ATOM 1388 O O     . LEU A 1 236 ? 130.290 142.149 162.667 1.00 50.62  ? 236 LEU A O     1 
ATOM 1389 C CB    . LEU A 1 236 ? 132.186 140.205 161.830 1.00 50.62  ? 236 LEU A CB    1 
ATOM 1390 C CG    . LEU A 1 236 ? 133.064 139.062 161.316 1.00 50.62  ? 236 LEU A CG    1 
ATOM 1391 C CD1   . LEU A 1 236 ? 134.283 138.872 162.205 1.00 50.62  ? 236 LEU A CD1   1 
ATOM 1392 C CD2   . LEU A 1 236 ? 132.276 137.769 161.195 1.00 50.62  ? 236 LEU A CD2   1 
ATOM 1393 N N     . SER A 1 237 ? 130.144 142.856 160.539 1.00 50.45  ? 237 SER A N     1 
ATOM 1394 C CA    . SER A 1 237 ? 129.745 144.212 160.901 1.00 50.45  ? 237 SER A CA    1 
ATOM 1395 C C     . SER A 1 237 ? 128.231 144.376 160.914 1.00 50.45  ? 237 SER A C     1 
ATOM 1396 O O     . SER A 1 237 ? 127.717 145.477 161.108 1.00 50.45  ? 237 SER A O     1 
ATOM 1397 C CB    . SER A 1 237 ? 130.356 145.216 159.926 1.00 50.45  ? 237 SER A CB    1 
ATOM 1398 O OG    . SER A 1 237 ? 129.809 145.050 158.630 1.00 50.45  ? 237 SER A OG    1 
ATOM 1399 N N     . ILE A 1 238 ? 127.524 143.278 160.690 1.00 48.52  ? 238 ILE A N     1 
ATOM 1400 C CA    . ILE A 1 238 ? 126.072 143.303 160.647 1.00 48.52  ? 238 ILE A CA    1 
ATOM 1401 C C     . ILE A 1 238 ? 125.559 143.087 162.067 1.00 48.52  ? 238 ILE A C     1 
ATOM 1402 O O     . ILE A 1 238 ? 126.053 142.216 162.772 1.00 48.52  ? 238 ILE A O     1 
ATOM 1403 C CB    . ILE A 1 238 ? 125.531 142.238 159.667 1.00 48.52  ? 238 ILE A CB    1 
ATOM 1404 C CG1   . ILE A 1 238 ? 125.871 142.618 158.220 1.00 48.52  ? 238 ILE A CG1   1 
ATOM 1405 C CG2   . ILE A 1 238 ? 124.027 142.082 159.791 1.00 48.52  ? 238 ILE A CG2   1 
ATOM 1406 C CD1   . ILE A 1 238 ? 127.193 142.080 157.710 1.00 48.52  ? 238 ILE A CD1   1 
ATOM 1407 N N     . PRO A 1 239 ? 124.614 143.929 162.514 1.00 49.45  ? 239 PRO A N     1 
ATOM 1408 C CA    . PRO A 1 239 ? 123.922 143.740 163.796 1.00 49.45  ? 239 PRO A CA    1 
ATOM 1409 C C     . PRO A 1 239 ? 122.976 142.539 163.823 1.00 49.45  ? 239 PRO A C     1 
ATOM 1410 O O     . PRO A 1 239 ? 122.597 142.003 162.783 1.00 49.45  ? 239 PRO A O     1 
ATOM 1411 C CB    . PRO A 1 239 ? 123.124 145.037 163.953 1.00 49.45  ? 239 PRO A CB    1 
ATOM 1412 C CG    . PRO A 1 239 ? 123.899 146.044 163.176 1.00 49.45  ? 239 PRO A CG    1 
ATOM 1413 C CD    . PRO A 1 239 ? 124.434 145.294 161.992 1.00 49.45  ? 239 PRO A CD    1 
ATOM 1414 N N     . LYS A 1 240 ? 122.601 142.129 165.030 1.00 49.21  ? 240 LYS A N     1 
ATOM 1415 C CA    . LYS A 1 240 ? 121.917 140.858 165.251 1.00 49.21  ? 240 LYS A CA    1 
ATOM 1416 C C     . LYS A 1 240 ? 120.620 140.721 164.459 1.00 49.21  ? 240 LYS A C     1 
ATOM 1417 O O     . LYS A 1 240 ? 119.746 141.586 164.519 1.00 49.21  ? 240 LYS A O     1 
ATOM 1418 C CB    . LYS A 1 240 ? 121.649 140.655 166.744 1.00 49.21  ? 240 LYS A CB    1 
ATOM 1419 C CG    . LYS A 1 240 ? 121.108 139.280 167.097 1.00 49.21  ? 240 LYS A CG    1 
ATOM 1420 C CD    . LYS A 1 240 ? 120.879 139.142 168.591 1.00 49.21  ? 240 LYS A CD    1 
ATOM 1421 C CE    . LYS A 1 240 ? 120.312 137.773 168.930 1.00 49.21  ? 240 LYS A CE    1 
ATOM 1422 N NZ    . LYS A 1 240 ? 119.026 137.523 168.223 1.00 49.21  ? 240 LYS A NZ    1 
ATOM 1423 N N     . GLY A 1 241 ? 120.505 139.623 163.718 1.00 49.14  ? 241 GLY A N     1 
ATOM 1424 C CA    . GLY A 1 241 ? 119.254 139.255 163.083 1.00 49.14  ? 241 GLY A CA    1 
ATOM 1425 C C     . GLY A 1 241 ? 119.237 139.482 161.585 1.00 49.14  ? 241 GLY A C     1 
ATOM 1426 O O     . GLY A 1 241 ? 118.797 138.621 160.824 1.00 49.14  ? 241 GLY A O     1 
ATOM 1427 N N     . GLN A 1 242 ? 119.715 140.648 161.163 1.00 48.95  ? 242 GLN A N     1 
ATOM 1428 C CA    . GLN A 1 242 ? 119.671 141.051 159.759 1.00 48.95  ? 242 GLN A CA    1 
ATOM 1429 C C     . GLN A 1 242 ? 120.356 140.023 158.865 1.00 48.95  ? 242 GLN A C     1 
ATOM 1430 O O     . GLN A 1 242 ? 121.517 139.697 159.082 1.00 48.95  ? 242 GLN A O     1 
ATOM 1431 C CB    . GLN A 1 242 ? 120.344 142.412 159.595 1.00 48.95  ? 242 GLN A CB    1 
ATOM 1432 C CG    . GLN A 1 242 ? 119.943 143.424 160.653 1.00 48.95  ? 242 GLN A CG    1 
ATOM 1433 C CD    . GLN A 1 242 ? 120.777 144.687 160.594 1.00 48.95  ? 242 GLN A CD    1 
ATOM 1434 O OE1   . GLN A 1 242 ? 121.677 144.811 159.765 1.00 48.95  ? 242 GLN A OE1   1 
ATOM 1435 N NE2   . GLN A 1 242 ? 120.481 145.633 161.477 1.00 48.95  ? 242 GLN A NE2   1 
ATOM 1436 N N     . PRO A 1 243 ? 119.633 139.514 157.852 1.00 44.95  ? 243 PRO A N     1 
ATOM 1437 C CA    . PRO A 1 243 ? 120.110 138.440 156.971 1.00 44.95  ? 243 PRO A CA    1 
ATOM 1438 C C     . PRO A 1 243 ? 121.548 138.652 156.509 1.00 44.95  ? 243 PRO A C     1 
ATOM 1439 O O     . PRO A 1 243 ? 121.820 139.529 155.689 1.00 44.95  ? 243 PRO A O     1 
ATOM 1440 C CB    . PRO A 1 243 ? 119.151 138.505 155.770 1.00 44.95  ? 243 PRO A CB    1 
ATOM 1441 C CG    . PRO A 1 243 ? 118.279 139.703 155.989 1.00 44.95  ? 243 PRO A CG    1 
ATOM 1442 C CD    . PRO A 1 243 ? 118.297 139.983 157.459 1.00 44.95  ? 243 PRO A CD    1 
ATOM 1443 N N     . GLY A 1 244 ? 122.458 137.843 157.040 1.00 42.81  ? 244 GLY A N     1 
ATOM 1444 C CA    . GLY A 1 244 ? 123.877 138.036 156.823 1.00 42.81  ? 244 GLY A CA    1 
ATOM 1445 C C     . GLY A 1 244 ? 124.600 138.135 158.150 1.00 42.81  ? 244 GLY A C     1 
ATOM 1446 O O     . GLY A 1 244 ? 125.825 138.238 158.198 1.00 42.81  ? 244 GLY A O     1 
ATOM 1447 N N     . TYR A 1 245 ? 123.832 138.101 159.234 1.00 44.46  ? 245 TYR A N     1 
ATOM 1448 C CA    . TYR A 1 245 ? 124.403 138.177 160.570 1.00 44.46  ? 245 TYR A CA    1 
ATOM 1449 C C     . TYR A 1 245 ? 125.153 136.900 160.917 1.00 44.46  ? 245 TYR A C     1 
ATOM 1450 O O     . TYR A 1 245 ? 124.607 135.806 160.863 1.00 44.46  ? 245 TYR A O     1 
ATOM 1451 C CB    . TYR A 1 245 ? 123.327 138.460 161.620 1.00 44.46  ? 245 TYR A CB    1 
ATOM 1452 C CG    . TYR A 1 245 ? 123.829 138.343 163.041 1.00 44.46  ? 245 TYR A CG    1 
ATOM 1453 C CD1   . TYR A 1 245 ? 124.756 139.245 163.546 1.00 44.46  ? 245 TYR A CD1   1 
ATOM 1454 C CD2   . TYR A 1 245 ? 123.381 137.327 163.875 1.00 44.46  ? 245 TYR A CD2   1 
ATOM 1455 C CE1   . TYR A 1 245 ? 125.221 139.141 164.841 1.00 44.46  ? 245 TYR A CE1   1 
ATOM 1456 C CE2   . TYR A 1 245 ? 123.842 137.214 165.172 1.00 44.46  ? 245 TYR A CE2   1 
ATOM 1457 C CZ    . TYR A 1 245 ? 124.761 138.124 165.650 1.00 44.46  ? 245 TYR A CZ    1 
ATOM 1458 O OH    . TYR A 1 245 ? 125.222 138.016 166.941 1.00 44.46  ? 245 TYR A OH    1 
ATOM 1459 N N     . VAL A 1 246 ? 126.416 137.058 161.280 1.00 43.46  ? 246 VAL A N     1 
ATOM 1460 C CA    . VAL A 1 246 ? 127.243 135.945 161.736 1.00 43.46  ? 246 VAL A CA    1 
ATOM 1461 C C     . VAL A 1 246 ? 127.137 135.840 163.253 1.00 43.46  ? 246 VAL A C     1 
ATOM 1462 O O     . VAL A 1 246 ? 127.427 136.816 163.961 1.00 43.46  ? 246 VAL A O     1 
ATOM 1463 C CB    . VAL A 1 246 ? 128.703 136.117 161.293 1.00 43.46  ? 246 VAL A CB    1 
ATOM 1464 C CG1   . VAL A 1 246 ? 129.548 134.967 161.802 1.00 43.46  ? 246 VAL A CG1   1 
ATOM 1465 C CG2   . VAL A 1 246 ? 128.787 136.220 159.781 1.00 43.46  ? 246 VAL A CG2   1 
ATOM 1466 N N     . PRO A 1 247 ? 126.724 134.695 163.794 1.00 45.50  ? 247 PRO A N     1 
ATOM 1467 C CA    . PRO A 1 247 ? 126.672 134.544 165.251 1.00 45.50  ? 247 PRO A CA    1 
ATOM 1468 C C     . PRO A 1 247 ? 128.064 134.601 165.864 1.00 45.50  ? 247 PRO A C     1 
ATOM 1469 O O     . PRO A 1 247 ? 129.070 134.286 165.226 1.00 45.50  ? 247 PRO A O     1 
ATOM 1470 C CB    . PRO A 1 247 ? 126.029 133.166 165.443 1.00 45.50  ? 247 PRO A CB    1 
ATOM 1471 C CG    . PRO A 1 247 ? 126.372 132.429 164.194 1.00 45.50  ? 247 PRO A CG    1 
ATOM 1472 C CD    . PRO A 1 247 ? 126.327 133.459 163.098 1.00 45.50  ? 247 PRO A CD    1 
ATOM 1473 N N     . GLU A 1 248 ? 128.107 135.018 167.131 1.00 45.98  ? 248 GLU A N     1 
ATOM 1474 C CA    . GLU A 1 248 ? 129.380 135.300 167.786 1.00 45.98  ? 248 GLU A CA    1 
ATOM 1475 C C     . GLU A 1 248 ? 130.245 134.060 167.976 1.00 45.98  ? 248 GLU A C     1 
ATOM 1476 O O     . GLU A 1 248 ? 131.473 134.182 168.026 1.00 45.98  ? 248 GLU A O     1 
ATOM 1477 C CB    . GLU A 1 248 ? 129.130 135.969 169.138 1.00 45.98  ? 248 GLU A CB    1 
ATOM 1478 C CG    . GLU A 1 248 ? 128.542 137.367 169.036 1.00 45.98  ? 248 GLU A CG    1 
ATOM 1479 C CD    . GLU A 1 248 ? 128.380 138.031 170.389 1.00 45.98  ? 248 GLU A CD    1 
ATOM 1480 O OE1   . GLU A 1 248 ? 128.605 137.356 171.415 1.00 45.98  ? 248 GLU A OE1   1 
ATOM 1481 O OE2   . GLU A 1 248 ? 128.029 139.229 170.426 1.00 45.98  ? 248 GLU A OE2   1 
ATOM 1482 N N     . TRP A 1 249 ? 129.645 132.873 168.090 1.00 46.30  ? 249 TRP A N     1 
ATOM 1483 C CA    . TRP A 1 249 ? 130.445 131.676 168.330 1.00 46.30  ? 249 TRP A CA    1 
ATOM 1484 C C     . TRP A 1 249 ? 131.156 131.220 167.062 1.00 46.30  ? 249 TRP A C     1 
ATOM 1485 O O     . TRP A 1 249 ? 132.222 130.597 167.133 1.00 46.30  ? 249 TRP A O     1 
ATOM 1486 C CB    . TRP A 1 249 ? 129.572 130.556 168.894 1.00 46.30  ? 249 TRP A CB    1 
ATOM 1487 C CG    . TRP A 1 249 ? 128.739 129.838 167.874 1.00 46.30  ? 249 TRP A CG    1 
ATOM 1488 C CD1   . TRP A 1 249 ? 127.510 130.206 167.411 1.00 46.30  ? 249 TRP A CD1   1 
ATOM 1489 C CD2   . TRP A 1 249 ? 129.069 128.615 167.206 1.00 46.30  ? 249 TRP A CD2   1 
ATOM 1490 N NE1   . TRP A 1 249 ? 127.057 129.293 166.491 1.00 46.30  ? 249 TRP A NE1   1 
ATOM 1491 C CE2   . TRP A 1 249 ? 127.996 128.306 166.347 1.00 46.30  ? 249 TRP A CE2   1 
ATOM 1492 C CE3   . TRP A 1 249 ? 130.169 127.753 167.248 1.00 46.30  ? 249 TRP A CE3   1 
ATOM 1493 C CZ2   . TRP A 1 249 ? 127.992 127.174 165.536 1.00 46.30  ? 249 TRP A CZ2   1 
ATOM 1494 C CZ3   . TRP A 1 249 ? 130.162 126.628 166.442 1.00 46.30  ? 249 TRP A CZ3   1 
ATOM 1495 C CH2   . TRP A 1 249 ? 129.081 126.349 165.598 1.00 46.30  ? 249 TRP A CH2   1 
ATOM 1496 N N     . GLN A 1 250 ? 130.585 131.517 165.894 1.00 45.08  ? 250 GLN A N     1 
ATOM 1497 C CA    . GLN A 1 250 ? 131.215 131.106 164.644 1.00 45.08  ? 250 GLN A CA    1 
ATOM 1498 C C     . GLN A 1 250 ? 132.411 131.986 164.303 1.00 45.08  ? 250 GLN A C     1 
ATOM 1499 O O     . GLN A 1 250 ? 133.266 131.594 163.502 1.00 45.08  ? 250 GLN A O     1 
ATOM 1500 C CB    . GLN A 1 250 ? 130.196 131.133 163.505 1.00 45.08  ? 250 GLN A CB    1 
ATOM 1501 C CG    . GLN A 1 250 ? 129.158 130.033 163.568 1.00 45.08  ? 250 GLN A CG    1 
ATOM 1502 C CD    . GLN A 1 250 ? 128.161 130.111 162.430 1.00 45.08  ? 250 GLN A CD    1 
ATOM 1503 O OE1   . GLN A 1 250 ? 128.194 131.040 161.624 1.00 45.08  ? 250 GLN A OE1   1 
ATOM 1504 N NE2   . GLN A 1 250 ? 127.265 129.133 162.360 1.00 45.08  ? 250 GLN A NE2   1 
ATOM 1505 N N     . ARG A 1 251 ? 132.480 133.184 164.885 1.00 46.64  ? 251 ARG A N     1 
ATOM 1506 C CA    . ARG A 1 251 ? 133.544 134.122 164.527 1.00 46.64  ? 251 ARG A CA    1 
ATOM 1507 C C     . ARG A 1 251 ? 134.938 133.569 164.797 1.00 46.64  ? 251 ARG A C     1 
ATOM 1508 O O     . ARG A 1 251 ? 135.825 133.760 163.947 1.00 46.64  ? 251 ARG A O     1 
ATOM 1509 C CB    . ARG A 1 251 ? 133.312 135.463 165.232 1.00 46.64  ? 251 ARG A CB    1 
ATOM 1510 C CG    . ARG A 1 251 ? 132.255 136.320 164.563 1.00 46.64  ? 251 ARG A CG    1 
ATOM 1511 C CD    . ARG A 1 251 ? 131.912 137.544 165.388 1.00 46.64  ? 251 ARG A CD    1 
ATOM 1512 N NE    . ARG A 1 251 ? 130.801 138.286 164.806 1.00 46.64  ? 251 ARG A NE    1 
ATOM 1513 C CZ    . ARG A 1 251 ? 130.341 139.437 165.276 1.00 46.64  ? 251 ARG A CZ    1 
ATOM 1514 N NH1   . ARG A 1 251 ? 130.876 140.013 166.340 1.00 46.64  ? 251 ARG A NH1   1 
ATOM 1515 N NH2   . ARG A 1 251 ? 129.318 140.025 164.663 1.00 46.64  ? 251 ARG A NH2   1 
ATOM 1516 N N     . PRO A 1 252 ? 135.219 132.913 165.925 1.00 47.07  ? 252 PRO A N     1 
ATOM 1517 C CA    . PRO A 1 252 ? 136.489 132.186 166.031 1.00 47.07  ? 252 PRO A CA    1 
ATOM 1518 C C     . PRO A 1 252 ? 136.553 131.054 165.015 1.00 47.07  ? 252 PRO A C     1 
ATOM 1519 O O     . PRO A 1 252 ? 135.531 130.480 164.633 1.00 47.07  ? 252 PRO A O     1 
ATOM 1520 C CB    . PRO A 1 252 ? 136.481 131.653 167.466 1.00 47.07  ? 252 PRO A CB    1 
ATOM 1521 C CG    . PRO A 1 252 ? 135.569 132.543 168.206 1.00 47.07  ? 252 PRO A CG    1 
ATOM 1522 C CD    . PRO A 1 252 ? 134.542 133.027 167.230 1.00 47.07  ? 252 PRO A CD    1 
ATOM 1523 N N     . HIS A 1 253 ? 137.773 130.751 164.569 1.00 50.44  ? 253 HIS A N     1 
ATOM 1524 C CA    . HIS A 1 253 ? 138.050 129.635 163.667 1.00 50.44  ? 253 HIS A CA    1 
ATOM 1525 C C     . HIS A 1 253 ? 137.433 129.819 162.284 1.00 50.44  ? 253 HIS A C     1 
ATOM 1526 O O     . HIS A 1 253 ? 137.090 128.834 161.622 1.00 50.44  ? 253 HIS A O     1 
ATOM 1527 C CB    . HIS A 1 253 ? 137.567 128.315 164.278 1.00 50.44  ? 253 HIS A CB    1 
ATOM 1528 C CG    . HIS A 1 253 ? 138.263 127.946 165.551 1.00 50.44  ? 253 HIS A CG    1 
ATOM 1529 N ND1   . HIS A 1 253 ? 139.598 127.607 165.599 1.00 50.44  ? 253 HIS A ND1   1 
ATOM 1530 C CD2   . HIS A 1 253 ? 137.807 127.858 166.823 1.00 50.44  ? 253 HIS A CD2   1 
ATOM 1531 C CE1   . HIS A 1 253 ? 139.935 127.328 166.845 1.00 50.44  ? 253 HIS A CE1   1 
ATOM 1532 N NE2   . HIS A 1 253 ? 138.866 127.473 167.608 1.00 50.44  ? 253 HIS A NE2   1 
ATOM 1533 N N     . LEU A 1 254 ? 137.288 131.062 161.832 1.00 45.75  ? 254 LEU A N     1 
ATOM 1534 C CA    . LEU A 1 254 ? 136.913 131.323 160.449 1.00 45.75  ? 254 LEU A CA    1 
ATOM 1535 C C     . LEU A 1 254 ? 138.136 131.119 159.556 1.00 45.75  ? 254 LEU A C     1 
ATOM 1536 O O     . LEU A 1 254 ? 139.216 130.740 160.018 1.00 45.75  ? 254 LEU A O     1 
ATOM 1537 C CB    . LEU A 1 254 ? 136.317 132.721 160.304 1.00 45.75  ? 254 LEU A CB    1 
ATOM 1538 C CG    . LEU A 1 254 ? 134.969 132.971 160.982 1.00 45.75  ? 254 LEU A CG    1 
ATOM 1539 C CD1   . LEU A 1 254 ? 134.571 134.433 160.878 1.00 45.75  ? 254 LEU A CD1   1 
ATOM 1540 C CD2   . LEU A 1 254 ? 133.900 132.085 160.369 1.00 45.75  ? 254 LEU A CD2   1 
ATOM 1541 N N     . SER A 1 255 ? 137.984 131.371 158.260 1.00 45.54  ? 255 SER A N     1 
ATOM 1542 C CA    . SER A 1 255 ? 139.059 131.133 157.308 1.00 45.54  ? 255 SER A CA    1 
ATOM 1543 C C     . SER A 1 255 ? 140.118 132.222 157.399 1.00 45.54  ? 255 SER A C     1 
ATOM 1544 O O     . SER A 1 255 ? 139.805 133.416 157.410 1.00 45.54  ? 255 SER A O     1 
ATOM 1545 C CB    . SER A 1 255 ? 138.517 131.061 155.880 1.00 45.54  ? 255 SER A CB    1 
ATOM 1546 O OG    . SER A 1 255 ? 137.647 129.956 155.720 1.00 45.54  ? 255 SER A OG    1 
ATOM 1547 N N     . THR A 1 256 ? 141.379 131.795 157.465 1.00 50.51  ? 256 THR A N     1 
ATOM 1548 C CA    . THR A 1 256 ? 142.524 132.690 157.359 1.00 50.51  ? 256 THR A CA    1 
ATOM 1549 C C     . THR A 1 256 ? 143.071 132.733 155.937 1.00 50.51  ? 256 THR A C     1 
ATOM 1550 O O     . THR A 1 256 ? 144.114 133.348 155.692 1.00 50.51  ? 256 THR A O     1 
ATOM 1551 C CB    . THR A 1 256 ? 143.622 132.274 158.338 1.00 50.51  ? 256 THR A CB    1 
ATOM 1552 O OG1   . THR A 1 256 ? 144.663 133.258 158.339 1.00 50.51  ? 256 THR A OG1   1 
ATOM 1553 C CG2   . THR A 1 256 ? 144.207 130.926 157.942 1.00 50.51  ? 256 THR A CG2   1 
ATOM 1554 N N     . LYS A 1 257 ? 142.381 132.093 154.997 1.00 52.05  ? 257 LYS A N     1 
ATOM 1555 C CA    . LYS A 1 257 ? 142.783 132.054 153.602 1.00 52.05  ? 257 LYS A CA    1 
ATOM 1556 C C     . LYS A 1 257 ? 141.727 132.750 152.757 1.00 52.05  ? 257 LYS A C     1 
ATOM 1557 O O     . LYS A 1 257 ? 140.539 132.753 153.089 1.00 52.05  ? 257 LYS A O     1 
ATOM 1558 C CB    . LYS A 1 257 ? 142.983 130.612 153.113 1.00 52.05  ? 257 LYS A CB    1 
ATOM 1559 C CG    . LYS A 1 257 ? 144.185 129.910 153.720 1.00 52.05  ? 257 LYS A CG    1 
ATOM 1560 C CD    . LYS A 1 257 ? 145.485 130.510 153.211 1.00 52.05  ? 257 LYS A CD    1 
ATOM 1561 C CE    . LYS A 1 257 ? 145.645 130.288 151.715 1.00 52.05  ? 257 LYS A CE    1 
ATOM 1562 N NZ    . LYS A 1 257 ? 146.902 130.892 151.195 1.00 52.05  ? 257 LYS A NZ    1 
ATOM 1563 N N     . ASN A 1 258 ? 142.172 133.342 151.654 1.00 51.04  ? 258 ASN A N     1 
ATOM 1564 C CA    . ASN A 1 258 ? 141.291 134.056 150.741 1.00 51.04  ? 258 ASN A CA    1 
ATOM 1565 C C     . ASN A 1 258 ? 140.641 133.054 149.796 1.00 51.04  ? 258 ASN A C     1 
ATOM 1566 O O     . ASN A 1 258 ? 141.306 132.508 148.909 1.00 51.04  ? 258 ASN A O     1 
ATOM 1567 C CB    . ASN A 1 258 ? 142.062 135.117 149.957 1.00 51.04  ? 258 ASN A CB    1 
ATOM 1568 C CG    . ASN A 1 258 ? 141.148 136.073 149.217 1.00 51.04  ? 258 ASN A CG    1 
ATOM 1569 O OD1   . ASN A 1 258 ? 139.924 135.959 149.285 1.00 51.04  ? 258 ASN A OD1   1 
ATOM 1570 N ND2   . ASN A 1 258 ? 141.740 137.029 148.511 1.00 51.04  ? 258 ASN A ND2   1 
ATOM 1571 N N     . LYS A 1 259 ? 139.345 132.820 149.983 1.00 42.98  ? 259 LYS A N     1 
ATOM 1572 C CA    . LYS A 1 259 ? 138.581 131.893 149.163 1.00 42.98  ? 259 LYS A CA    1 
ATOM 1573 C C     . LYS A 1 259 ? 137.378 132.623 148.584 1.00 42.98  ? 259 LYS A C     1 
ATOM 1574 O O     . LYS A 1 259 ? 137.169 133.815 148.828 1.00 42.98  ? 259 LYS A O     1 
ATOM 1575 C CB    . LYS A 1 259 ? 138.118 130.679 149.973 1.00 42.98  ? 259 LYS A CB    1 
ATOM 1576 C CG    . LYS A 1 259 ? 137.089 131.034 151.027 1.00 42.98  ? 259 LYS A CG    1 
ATOM 1577 C CD    . LYS A 1 259 ? 136.669 129.820 151.819 1.00 42.98  ? 259 LYS A CD    1 
ATOM 1578 C CE    . LYS A 1 259 ? 135.672 130.191 152.895 1.00 42.98  ? 259 LYS A CE    1 
ATOM 1579 N NZ    . LYS A 1 259 ? 134.379 130.649 152.325 1.00 42.98  ? 259 LYS A NZ    1 
ATOM 1580 N N     . ARG A 1 260 ? 136.581 131.896 147.805 1.00 39.10  ? 260 ARG A N     1 
ATOM 1581 C CA    . ARG A 1 260 ? 135.335 132.458 147.309 1.00 39.10  ? 260 ARG A CA    1 
ATOM 1582 C C     . ARG A 1 260 ? 134.400 132.738 148.475 1.00 39.10  ? 260 ARG A C     1 
ATOM 1583 O O     . ARG A 1 260 ? 134.281 131.934 149.403 1.00 39.10  ? 260 ARG A O     1 
ATOM 1584 C CB    . ARG A 1 260 ? 134.660 131.505 146.324 1.00 39.10  ? 260 ARG A CB    1 
ATOM 1585 C CG    . ARG A 1 260 ? 133.368 132.061 145.751 1.00 39.10  ? 260 ARG A CG    1 
ATOM 1586 C CD    . ARG A 1 260 ? 132.544 130.995 145.071 1.00 39.10  ? 260 ARG A CD    1 
ATOM 1587 N NE    . ARG A 1 260 ? 131.123 131.311 145.114 1.00 39.10  ? 260 ARG A NE    1 
ATOM 1588 C CZ    . ARG A 1 260 ? 130.209 130.740 144.343 1.00 39.10  ? 260 ARG A CZ    1 
ATOM 1589 N NH1   . ARG A 1 260 ? 130.528 129.787 143.484 1.00 39.10  ? 260 ARG A NH1   1 
ATOM 1590 N NH2   . ARG A 1 260 ? 128.943 131.136 144.435 1.00 39.10  ? 260 ARG A NH2   1 
ATOM 1591 N N     . ILE A 1 261 ? 133.734 133.884 148.427 1.00 40.50  ? 261 ILE A N     1 
ATOM 1592 C CA    . ILE A 1 261 ? 132.799 134.286 149.468 1.00 40.50  ? 261 ILE A CA    1 
ATOM 1593 C C     . ILE A 1 261 ? 131.380 134.112 148.944 1.00 40.50  ? 261 ILE A C     1 
ATOM 1594 O O     . ILE A 1 261 ? 131.011 134.680 147.908 1.00 40.50  ? 261 ILE A O     1 
ATOM 1595 C CB    . ILE A 1 261 ? 133.078 135.725 149.945 1.00 40.50  ? 261 ILE A CB    1 
ATOM 1596 C CG1   . ILE A 1 261 ? 132.270 136.049 151.198 1.00 40.50  ? 261 ILE A CG1   1 
ATOM 1597 C CG2   . ILE A 1 261 ? 132.854 136.765 148.845 1.00 40.50  ? 261 ILE A CG2   1 
ATOM 1598 C CD1   . ILE A 1 261 ? 132.742 137.301 151.884 1.00 40.50  ? 261 ILE A CD1   1 
ATOM 1599 N N     . ARG A 1 262 ? 130.603 133.276 149.625 1.00 40.23  ? 262 ARG A N     1 
ATOM 1600 C CA    . ARG A 1 262 ? 129.213 133.030 149.276 1.00 40.23  ? 262 ARG A CA    1 
ATOM 1601 C C     . ARG A 1 262 ? 128.332 134.094 149.910 1.00 40.23  ? 262 ARG A C     1 
ATOM 1602 O O     . ARG A 1 262 ? 128.631 134.592 150.999 1.00 40.23  ? 262 ARG A O     1 
ATOM 1603 C CB    . ARG A 1 262 ? 128.760 131.642 149.734 1.00 40.23  ? 262 ARG A CB    1 
ATOM 1604 C CG    . ARG A 1 262 ? 129.441 130.497 149.010 1.00 40.23  ? 262 ARG A CG    1 
ATOM 1605 C CD    . ARG A 1 262 ? 128.758 129.176 149.316 1.00 40.23  ? 262 ARG A CD    1 
ATOM 1606 N NE    . ARG A 1 262 ? 128.787 128.853 150.737 1.00 40.23  ? 262 ARG A NE    1 
ATOM 1607 C CZ    . ARG A 1 262 ? 129.786 128.224 151.340 1.00 40.23  ? 262 ARG A CZ    1 
ATOM 1608 N NH1   . ARG A 1 262 ? 130.862 127.836 150.674 1.00 40.23  ? 262 ARG A NH1   1 
ATOM 1609 N NH2   . ARG A 1 262 ? 129.704 127.976 152.644 1.00 40.23  ? 262 ARG A NH2   1 
ATOM 1610 N N     . LYS A 1 263 ? 127.253 134.445 149.222 1.00 39.00  ? 263 LYS A N     1 
ATOM 1611 C CA    . LYS A 1 263 ? 126.326 135.424 149.757 1.00 39.00  ? 263 LYS A CA    1 
ATOM 1612 C C     . LYS A 1 263 ? 125.117 134.706 150.360 1.00 39.00  ? 263 LYS A C     1 
ATOM 1613 O O     . LYS A 1 263 ? 124.827 133.549 150.042 1.00 39.00  ? 263 LYS A O     1 
ATOM 1614 C CB    . LYS A 1 263 ? 125.941 136.421 148.664 1.00 39.00  ? 263 LYS A CB    1 
ATOM 1615 C CG    . LYS A 1 263 ? 125.093 137.586 149.120 1.00 39.00  ? 263 LYS A CG    1 
ATOM 1616 C CD    . LYS A 1 263 ? 124.795 138.503 147.957 1.00 39.00  ? 263 LYS A CD    1 
ATOM 1617 C CE    . LYS A 1 263 ? 126.034 139.264 147.521 1.00 39.00  ? 263 LYS A CE    1 
ATOM 1618 N NZ    . LYS A 1 263 ? 126.482 140.230 148.558 1.00 39.00  ? 263 LYS A NZ    1 
ATOM 1619 N N     . TRP A 1 264 ? 124.410 135.404 151.255 1.00 37.93  ? 264 TRP A N     1 
ATOM 1620 C CA    . TRP A 1 264 ? 123.501 134.726 152.177 1.00 37.93  ? 264 TRP A CA    1 
ATOM 1621 C C     . TRP A 1 264 ? 122.371 133.993 151.462 1.00 37.93  ? 264 TRP A C     1 
ATOM 1622 O O     . TRP A 1 264 ? 121.790 133.063 152.032 1.00 37.93  ? 264 TRP A O     1 
ATOM 1623 C CB    . TRP A 1 264 ? 122.931 135.723 153.189 1.00 37.93  ? 264 TRP A CB    1 
ATOM 1624 C CG    . TRP A 1 264 ? 122.114 136.832 152.600 1.00 37.93  ? 264 TRP A CG    1 
ATOM 1625 C CD1   . TRP A 1 264 ? 122.569 138.043 152.169 1.00 37.93  ? 264 TRP A CD1   1 
ATOM 1626 C CD2   . TRP A 1 264 ? 120.693 136.850 152.420 1.00 37.93  ? 264 TRP A CD2   1 
ATOM 1627 N NE1   . TRP A 1 264 ? 121.523 138.805 151.710 1.00 37.93  ? 264 TRP A NE1   1 
ATOM 1628 C CE2   . TRP A 1 264 ? 120.360 138.096 151.857 1.00 37.93  ? 264 TRP A CE2   1 
ATOM 1629 C CE3   . TRP A 1 264 ? 119.671 135.931 152.673 1.00 37.93  ? 264 TRP A CE3   1 
ATOM 1630 C CZ2   . TRP A 1 264 ? 119.051 138.445 151.540 1.00 37.93  ? 264 TRP A CZ2   1 
ATOM 1631 C CZ3   . TRP A 1 264 ? 118.373 136.281 152.361 1.00 37.93  ? 264 TRP A CZ3   1 
ATOM 1632 C CH2   . TRP A 1 264 ? 118.074 137.524 151.800 1.00 37.93  ? 264 TRP A CH2   1 
ATOM 1633 N N     . TYR A 1 265 ? 122.045 134.373 150.226 1.00 40.49  ? 265 TYR A N     1 
ATOM 1634 C CA    . TYR A 1 265 ? 120.969 133.708 149.501 1.00 40.49  ? 265 TYR A CA    1 
ATOM 1635 C C     . TYR A 1 265 ? 121.481 132.686 148.494 1.00 40.49  ? 265 TYR A C     1 
ATOM 1636 O O     . TYR A 1 265 ? 120.772 132.361 147.535 1.00 40.49  ? 265 TYR A O     1 
ATOM 1637 C CB    . TYR A 1 265 ? 120.062 134.724 148.803 1.00 40.49  ? 265 TYR A CB    1 
ATOM 1638 C CG    . TYR A 1 265 ? 120.758 135.762 147.953 1.00 40.49  ? 265 TYR A CG    1 
ATOM 1639 C CD1   . TYR A 1 265 ? 120.825 137.086 148.357 1.00 40.49  ? 265 TYR A CD1   1 
ATOM 1640 C CD2   . TYR A 1 265 ? 121.331 135.420 146.735 1.00 40.49  ? 265 TYR A CD2   1 
ATOM 1641 C CE1   . TYR A 1 265 ? 121.447 138.038 147.577 1.00 40.49  ? 265 TYR A CE1   1 
ATOM 1642 C CE2   . TYR A 1 265 ? 121.961 136.363 145.952 1.00 40.49  ? 265 TYR A CE2   1 
ATOM 1643 C CZ    . TYR A 1 265 ? 122.015 137.670 146.375 1.00 40.49  ? 265 TYR A CZ    1 
ATOM 1644 O OH    . TYR A 1 265 ? 122.642 138.612 145.592 1.00 40.49  ? 265 TYR A OH    1 
ATOM 1645 N N     . ALA A 1 266 ? 122.692 132.173 148.686 1.00 39.57  ? 266 ALA A N     1 
ATOM 1646 C CA    . ALA A 1 266 ? 123.185 131.099 147.843 1.00 39.57  ? 266 ALA A CA    1 
ATOM 1647 C C     . ALA A 1 266 ? 122.472 129.792 148.176 1.00 39.57  ? 266 ALA A C     1 
ATOM 1648 O O     . ALA A 1 266 ? 122.171 129.495 149.335 1.00 39.57  ? 266 ALA A O     1 
ATOM 1649 C CB    . ALA A 1 266 ? 124.695 130.932 148.008 1.00 39.57  ? 266 ALA A CB    1 
ATOM 1650 N N     . ARG A 1 267 ? 122.197 129.006 147.134 1.00 41.75  ? 267 ARG A N     1 
ATOM 1651 C CA    . ARG A 1 267 ? 121.491 127.744 147.332 1.00 41.75  ? 267 ARG A CA    1 
ATOM 1652 C C     . ARG A 1 267 ? 122.357 126.729 148.066 1.00 41.75  ? 267 ARG A C     1 
ATOM 1653 O O     . ARG A 1 267 ? 121.836 125.831 148.738 1.00 41.75  ? 267 ARG A O     1 
ATOM 1654 C CB    . ARG A 1 267 ? 121.025 127.181 145.990 1.00 41.75  ? 267 ARG A CB    1 
ATOM 1655 C CG    . ARG A 1 267 ? 119.877 127.951 145.357 1.00 41.75  ? 267 ARG A CG    1 
ATOM 1656 C CD    . ARG A 1 267 ? 119.364 127.238 144.119 1.00 41.75  ? 267 ARG A CD    1 
ATOM 1657 N NE    . ARG A 1 267 ? 118.733 125.965 144.449 1.00 41.75  ? 267 ARG A NE    1 
ATOM 1658 C CZ    . ARG A 1 267 ? 118.362 125.059 143.556 1.00 41.75  ? 267 ARG A CZ    1 
ATOM 1659 N NH1   . ARG A 1 267 ? 118.542 125.251 142.260 1.00 41.75  ? 267 ARG A NH1   1 
ATOM 1660 N NH2   . ARG A 1 267 ? 117.796 123.930 143.974 1.00 41.75  ? 267 ARG A NH2   1 
ATOM 1661 N N     . ALA A 1 268 ? 123.681 126.847 147.943 1.00 41.50  ? 268 ALA A N     1 
ATOM 1662 C CA    . ALA A 1 268 ? 124.570 125.954 148.677 1.00 41.50  ? 268 ALA A CA    1 
ATOM 1663 C C     . ALA A 1 268 ? 124.419 126.143 150.180 1.00 41.50  ? 268 ALA A C     1 
ATOM 1664 O O     . ALA A 1 268 ? 124.618 125.201 150.956 1.00 41.50  ? 268 ALA A O     1 
ATOM 1665 C CB    . ALA A 1 268 ? 126.018 126.184 148.247 1.00 41.50  ? 268 ALA A CB    1 
ATOM 1666 N N     . ASN A 1 269 ? 124.070 127.357 150.609 1.00 41.86  ? 269 ASN A N     1 
ATOM 1667 C CA    . ASN A 1 269 ? 123.864 127.622 152.026 1.00 41.86  ? 269 ASN A CA    1 
ATOM 1668 C C     . ASN A 1 269 ? 122.520 127.108 152.524 1.00 41.86  ? 269 ASN A C     1 
ATOM 1669 O O     . ASN A 1 269 ? 122.329 126.993 153.739 1.00 41.86  ? 269 ASN A O     1 
ATOM 1670 C CB    . ASN A 1 269 ? 123.970 129.121 152.301 1.00 41.86  ? 269 ASN A CB    1 
ATOM 1671 C CG    . ASN A 1 269 ? 125.399 129.591 152.432 1.00 41.86  ? 269 ASN A CG    1 
ATOM 1672 O OD1   . ASN A 1 269 ? 126.331 128.787 152.451 1.00 41.86  ? 269 ASN A OD1   1 
ATOM 1673 N ND2   . ASN A 1 269 ? 125.583 130.900 152.520 1.00 41.86  ? 269 ASN A ND2   1 
ATOM 1674 N N     . TRP A 1 270 ? 121.591 126.796 151.624 1.00 45.35  ? 270 TRP A N     1 
ATOM 1675 C CA    . TRP A 1 270 ? 120.230 126.431 151.993 1.00 45.35  ? 270 TRP A CA    1 
ATOM 1676 C C     . TRP A 1 270 ? 119.828 125.070 151.435 1.00 45.35  ? 270 TRP A C     1 
ATOM 1677 O O     . TRP A 1 270 ? 118.671 124.662 151.538 1.00 45.35  ? 270 TRP A O     1 
ATOM 1678 C CB    . TRP A 1 270 ? 119.237 127.494 151.529 1.00 45.35  ? 270 TRP A CB    1 
ATOM 1679 C CG    . TRP A 1 270 ? 119.439 128.846 152.133 1.00 45.35  ? 270 TRP A CG    1 
ATOM 1680 C CD1   . TRP A 1 270 ? 120.417 129.743 151.828 1.00 45.35  ? 270 TRP A CD1   1 
ATOM 1681 C CD2   . TRP A 1 270 ? 118.627 129.463 153.137 1.00 45.35  ? 270 TRP A CD2   1 
ATOM 1682 N NE1   . TRP A 1 270 ? 120.271 130.879 152.586 1.00 45.35  ? 270 TRP A NE1   1 
ATOM 1683 C CE2   . TRP A 1 270 ? 119.178 130.731 153.398 1.00 45.35  ? 270 TRP A CE2   1 
ATOM 1684 C CE3   . TRP A 1 270 ? 117.490 129.063 153.845 1.00 45.35  ? 270 TRP A CE3   1 
ATOM 1685 C CZ2   . TRP A 1 270 ? 118.632 131.604 154.336 1.00 45.35  ? 270 TRP A CZ2   1 
ATOM 1686 C CZ3   . TRP A 1 270 ? 116.949 129.930 154.775 1.00 45.35  ? 270 TRP A CZ3   1 
ATOM 1687 C CH2   . TRP A 1 270 ? 117.519 131.185 155.013 1.00 45.35  ? 270 TRP A CH2   1 
ATOM 1688 N N     . ARG A 1 271 ? 120.769 124.341 150.839 1.00 45.53  ? 271 ARG A N     1 
ATOM 1689 C CA    . ARG A 1 271 ? 120.447 123.068 150.206 1.00 45.53  ? 271 ARG A CA    1 
ATOM 1690 C C     . ARG A 1 271 ? 120.062 122.048 151.271 1.00 45.53  ? 271 ARG A C     1 
ATOM 1691 O O     . ARG A 1 271 ? 120.681 121.986 152.338 1.00 45.53  ? 271 ARG A O     1 
ATOM 1692 C CB    . ARG A 1 271 ? 121.616 122.557 149.359 1.00 45.53  ? 271 ARG A CB    1 
ATOM 1693 C CG    . ARG A 1 271 ? 122.757 121.918 150.131 1.00 45.53  ? 271 ARG A CG    1 
ATOM 1694 C CD    . ARG A 1 271 ? 123.881 121.496 149.200 1.00 45.53  ? 271 ARG A CD    1 
ATOM 1695 N NE    . ARG A 1 271 ? 124.835 120.612 149.858 1.00 45.53  ? 271 ARG A NE    1 
ATOM 1696 C CZ    . ARG A 1 271 ? 125.850 121.023 150.604 1.00 45.53  ? 271 ARG A CZ    1 
ATOM 1697 N NH1   . ARG A 1 271 ? 126.075 122.308 150.820 1.00 45.53  ? 271 ARG A NH1   1 
ATOM 1698 N NH2   . ARG A 1 271 ? 126.661 120.121 151.148 1.00 45.53  ? 271 ARG A NH2   1 
ATOM 1699 N N     . ARG A 1 272 ? 119.017 121.274 150.991 1.00 50.07  ? 272 ARG A N     1 
ATOM 1700 C CA    . ARG A 1 272 ? 118.519 120.312 151.963 1.00 50.07  ? 272 ARG A CA    1 
ATOM 1701 C C     . ARG A 1 272 ? 119.462 119.122 152.078 1.00 50.07  ? 272 ARG A C     1 
ATOM 1702 O O     . ARG A 1 272 ? 119.991 118.626 151.080 1.00 50.07  ? 272 ARG A O     1 
ATOM 1703 C CB    . ARG A 1 272 ? 117.118 119.841 151.579 1.00 50.07  ? 272 ARG A CB    1 
ATOM 1704 C CG    . ARG A 1 272 ? 116.090 120.957 151.529 1.00 50.07  ? 272 ARG A CG    1 
ATOM 1705 C CD    . ARG A 1 272 ? 114.683 120.434 151.763 1.00 50.07  ? 272 ARG A CD    1 
ATOM 1706 N NE    . ARG A 1 272 ? 113.671 121.424 151.416 1.00 50.07  ? 272 ARG A NE    1 
ATOM 1707 C CZ    . ARG A 1 272 ? 112.363 121.222 151.506 1.00 50.07  ? 272 ARG A CZ    1 
ATOM 1708 N NH1   . ARG A 1 272 ? 111.869 120.071 151.932 1.00 50.07  ? 272 ARG A NH1   1 
ATOM 1709 N NH2   . ARG A 1 272 ? 111.531 122.201 151.162 1.00 50.07  ? 272 ARG A NH2   1 
ATOM 1710 N N     . LYS A 1 273 ? 119.668 118.670 153.308 1.00 47.66  ? 273 LYS A N     1 
ATOM 1711 C CA    . LYS A 1 273 ? 120.530 117.530 153.590 1.00 47.66  ? 273 LYS A CA    1 
ATOM 1712 C C     . LYS A 1 273 ? 120.136 116.972 154.950 1.00 47.66  ? 273 LYS A C     1 
ATOM 1713 O O     . LYS A 1 273 ? 119.487 117.665 155.747 1.00 47.66  ? 273 LYS A O     1 
ATOM 1714 C CB    . LYS A 1 273 ? 122.017 117.930 153.547 1.00 47.66  ? 273 LYS A CB    1 
ATOM 1715 C CG    . LYS A 1 273 ? 122.494 118.797 154.697 1.00 47.66  ? 273 LYS A CG    1 
ATOM 1716 C CD    . LYS A 1 273 ? 123.896 119.315 154.419 1.00 47.66  ? 273 LYS A CD    1 
ATOM 1717 C CE    . LYS A 1 273 ? 124.444 120.119 155.582 1.00 47.66  ? 273 LYS A CE    1 
ATOM 1718 N NZ    . LYS A 1 273 ? 124.834 119.245 156.720 1.00 47.66  ? 273 LYS A NZ    1 
ATOM 1719 N N     . PRO A 1 274 ? 120.491 115.714 155.240 1.00 47.71  ? 274 PRO A N     1 
ATOM 1720 C CA    . PRO A 1 274 ? 119.990 115.087 156.478 1.00 47.71  ? 274 PRO A CA    1 
ATOM 1721 C C     . PRO A 1 274 ? 120.345 115.842 157.749 1.00 47.71  ? 274 PRO A C     1 
ATOM 1722 O O     . PRO A 1 274 ? 119.572 115.809 158.714 1.00 47.71  ? 274 PRO A O     1 
ATOM 1723 C CB    . PRO A 1 274 ? 120.639 113.697 156.442 1.00 47.71  ? 274 PRO A CB    1 
ATOM 1724 C CG    . PRO A 1 274 ? 120.814 113.418 154.994 1.00 47.71  ? 274 PRO A CG    1 
ATOM 1725 C CD    . PRO A 1 274 ? 121.186 114.738 154.381 1.00 47.71  ? 274 PRO A CD    1 
ATOM 1726 N N     . GLY A 1 275 ? 121.490 116.520 157.783 1.00 46.39  ? 275 GLY A N     1 
ATOM 1727 C CA    . GLY A 1 275 ? 121.907 117.254 158.959 1.00 46.39  ? 275 GLY A CA    1 
ATOM 1728 C C     . GLY A 1 275 ? 121.447 118.691 159.041 1.00 46.39  ? 275 GLY A C     1 
ATOM 1729 O O     . GLY A 1 275 ? 121.813 119.385 160.000 1.00 46.39  ? 275 GLY A O     1 
ATOM 1730 N N     . ARG A 1 276 ? 120.653 119.170 158.089 1.00 47.67  ? 276 ARG A N     1 
ATOM 1731 C CA    . ARG A 1 276 ? 120.248 120.566 158.034 1.00 47.67  ? 276 ARG A CA    1 
ATOM 1732 C C     . ARG A 1 276 ? 118.773 120.707 158.383 1.00 47.67  ? 276 ARG A C     1 
ATOM 1733 O O     . ARG A 1 276 ? 117.942 119.903 157.952 1.00 47.67  ? 276 ARG A O     1 
ATOM 1734 C CB    . ARG A 1 276 ? 120.511 121.153 156.646 1.00 47.67  ? 276 ARG A CB    1 
ATOM 1735 C CG    . ARG A 1 276 ? 119.996 122.570 156.456 1.00 47.67  ? 276 ARG A CG    1 
ATOM 1736 C CD    . ARG A 1 276 ? 120.671 123.236 155.274 1.00 47.67  ? 276 ARG A CD    1 
ATOM 1737 N NE    . ARG A 1 276 ? 122.122 123.121 155.342 1.00 47.67  ? 276 ARG A NE    1 
ATOM 1738 C CZ    . ARG A 1 276 ? 122.950 123.533 154.393 1.00 47.67  ? 276 ARG A CZ    1 
ATOM 1739 N NH1   . ARG A 1 276 ? 122.502 124.090 153.281 1.00 47.67  ? 276 ARG A NH1   1 
ATOM 1740 N NH2   . ARG A 1 276 ? 124.259 123.379 154.563 1.00 47.67  ? 276 ARG A NH2   1 
ATOM 1741 N N     . LYS A 1 277 ? 118.456 121.735 159.165 1.00 49.00  ? 277 LYS A N     1 
ATOM 1742 C CA    . LYS A 1 277 ? 117.088 122.041 159.564 1.00 49.00  ? 277 LYS A CA    1 
ATOM 1743 C C     . LYS A 1 277 ? 116.714 123.456 159.151 1.00 49.00  ? 277 LYS A C     1 
ATOM 1744 O O     . LYS A 1 277 ? 115.987 124.159 159.858 1.00 49.00  ? 277 LYS A O     1 
ATOM 1745 C CB    . LYS A 1 277 ? 116.901 121.849 161.067 1.00 49.00  ? 277 LYS A CB    1 
ATOM 1746 C CG    . LYS A 1 277 ? 116.928 120.398 161.514 1.00 49.00  ? 277 LYS A CG    1 
ATOM 1747 C CD    . LYS A 1 277 ? 116.866 120.285 163.028 1.00 49.00  ? 277 LYS A CD    1 
ATOM 1748 C CE    . LYS A 1 277 ? 116.963 118.837 163.478 1.00 49.00  ? 277 LYS A CE    1 
ATOM 1749 N NZ    . LYS A 1 277 ? 116.915 118.711 164.961 1.00 49.00  ? 277 LYS A NZ    1 
ATOM 1750 N N     . SER A 1 278 ? 117.202 123.893 157.994 1.00 51.19  ? 278 SER A N     1 
ATOM 1751 C CA    . SER A 1 278 ? 116.917 125.221 157.470 1.00 51.19  ? 278 SER A CA    1 
ATOM 1752 C C     . SER A 1 278 ? 115.775 125.145 156.467 1.00 51.19  ? 278 SER A C     1 
ATOM 1753 O O     . SER A 1 278 ? 115.788 124.309 155.558 1.00 51.19  ? 278 SER A O     1 
ATOM 1754 C CB    . SER A 1 278 ? 118.154 125.831 156.807 1.00 51.19  ? 278 SER A CB    1 
ATOM 1755 O OG    . SER A 1 278 ? 118.285 125.385 155.468 1.00 51.19  ? 278 SER A OG    1 
ATOM 1756 N N     . VAL A 1 279 ? 114.789 126.023 156.635 1.00 52.79  ? 279 VAL A N     1 
ATOM 1757 C CA    . VAL A 1 279 ? 113.615 126.017 155.770 1.00 52.79  ? 279 VAL A CA    1 
ATOM 1758 C C     . VAL A 1 279 ? 113.953 126.709 154.455 1.00 52.79  ? 279 VAL A C     1 
ATOM 1759 O O     . VAL A 1 279 ? 114.535 127.800 154.438 1.00 52.79  ? 279 VAL A O     1 
ATOM 1760 C CB    . VAL A 1 279 ? 112.420 126.682 156.465 1.00 52.79  ? 279 VAL A CB    1 
ATOM 1761 C CG1   . VAL A 1 279 ? 111.869 125.769 157.549 1.00 52.79  ? 279 VAL A CG1   1 
ATOM 1762 C CG2   . VAL A 1 279 ? 112.827 128.019 157.064 1.00 52.79  ? 279 VAL A CG2   1 
ATOM 1763 N N     . LEU A 1 280 ? 113.599 126.067 153.343 1.00 55.02  ? 280 LEU A N     1 
ATOM 1764 C CA    . LEU A 1 280 ? 113.776 126.634 152.010 1.00 55.02  ? 280 LEU A CA    1 
ATOM 1765 C C     . LEU A 1 280 ? 112.482 127.315 151.583 1.00 55.02  ? 280 LEU A C     1 
ATOM 1766 O O     . LEU A 1 280 ? 111.441 126.661 151.451 1.00 55.02  ? 280 LEU A O     1 
ATOM 1767 C CB    . LEU A 1 280 ? 114.175 125.559 151.001 1.00 55.02  ? 280 LEU A CB    1 
ATOM 1768 C CG    . LEU A 1 280 ? 115.664 125.401 150.709 1.00 55.02  ? 280 LEU A CG    1 
ATOM 1769 C CD1   . LEU A 1 280 ? 115.917 124.140 149.909 1.00 55.02  ? 280 LEU A CD1   1 
ATOM 1770 C CD2   . LEU A 1 280 ? 116.160 126.617 149.951 1.00 55.02  ? 280 LEU A CD2   1 
ATOM 1771 N N     . ASP A 1 281 ? 112.550 128.624 151.366 1.00 57.62  ? 281 ASP A N     1 
ATOM 1772 C CA    . ASP A 1 281 ? 111.451 129.397 150.809 1.00 57.62  ? 281 ASP A CA    1 
ATOM 1773 C C     . ASP A 1 281 ? 111.976 130.186 149.621 1.00 57.62  ? 281 ASP A C     1 
ATOM 1774 O O     . ASP A 1 281 ? 112.688 131.181 149.798 1.00 57.62  ? 281 ASP A O     1 
ATOM 1775 C CB    . ASP A 1 281 ? 110.845 130.337 151.855 1.00 57.62  ? 281 ASP A CB    1 
ATOM 1776 C CG    . ASP A 1 281 ? 109.968 129.610 152.856 1.00 57.62  ? 281 ASP A CG    1 
ATOM 1777 O OD1   . ASP A 1 281 ? 109.546 128.471 152.564 1.00 57.62  ? 281 ASP A OD1   1 
ATOM 1778 O OD2   . ASP A 1 281 ? 109.699 130.177 153.936 1.00 57.62  ? 281 ASP A OD2   1 
ATOM 1779 N N     . GLU A 1 282 ? 111.626 129.744 148.413 1.00 56.31  ? 282 GLU A N     1 
ATOM 1780 C CA    . GLU A 1 282 ? 112.137 130.341 147.187 1.00 56.31  ? 282 GLU A CA    1 
ATOM 1781 C C     . GLU A 1 282 ? 111.423 131.637 146.827 1.00 56.31  ? 282 GLU A C     1 
ATOM 1782 O O     . GLU A 1 282 ? 111.676 132.201 145.758 1.00 56.31  ? 282 GLU A O     1 
ATOM 1783 C CB    . GLU A 1 282 ? 112.046 129.343 146.032 1.00 56.31  ? 282 GLU A CB    1 
ATOM 1784 C CG    . GLU A 1 282 ? 113.023 128.182 146.137 1.00 56.31  ? 282 GLU A CG    1 
ATOM 1785 C CD    . GLU A 1 282 ? 112.496 127.046 146.992 1.00 56.31  ? 282 GLU A CD    1 
ATOM 1786 O OE1   . GLU A 1 282 ? 111.334 127.128 147.443 1.00 56.31  ? 282 GLU A OE1   1 
ATOM 1787 O OE2   . GLU A 1 282 ? 113.245 126.071 147.213 1.00 56.31  ? 282 GLU A OE2   1 
ATOM 1788 N N     . ALA A 1 283 ? 110.537 132.118 147.693 1.00 56.61  ? 283 ALA A N     1 
ATOM 1789 C CA    . ALA A 1 283 ? 109.938 133.434 147.538 1.00 56.61  ? 283 ALA A CA    1 
ATOM 1790 C C     . ALA A 1 283 ? 110.846 134.542 148.050 1.00 56.61  ? 283 ALA A C     1 
ATOM 1791 O O     . ALA A 1 283 ? 110.518 135.723 147.893 1.00 56.61  ? 283 ALA A O     1 
ATOM 1792 C CB    . ALA A 1 283 ? 108.587 133.490 148.256 1.00 56.61  ? 283 ALA A CB    1 
ATOM 1793 N N     . LYS A 1 284 ? 111.977 134.185 148.661 1.00 55.43  ? 284 LYS A N     1 
ATOM 1794 C CA    . LYS A 1 284 ? 112.943 135.156 149.164 1.00 55.43  ? 284 LYS A CA    1 
ATOM 1795 C C     . LYS A 1 284 ? 114.307 134.982 148.511 1.00 55.43  ? 284 LYS A C     1 
ATOM 1796 O O     . LYS A 1 284 ? 114.961 135.979 148.188 1.00 55.43  ? 284 LYS A O     1 
ATOM 1797 C CB    . LYS A 1 284 ? 113.055 135.040 150.689 1.00 55.43  ? 284 LYS A CB    1 
ATOM 1798 C CG    . LYS A 1 284 ? 111.735 135.203 151.425 1.00 55.43  ? 284 LYS A CG    1 
ATOM 1799 C CD    . LYS A 1 284 ? 111.185 136.611 151.272 1.00 55.43  ? 284 LYS A CD    1 
ATOM 1800 C CE    . LYS A 1 284 ? 109.738 136.691 151.729 1.00 55.43  ? 284 LYS A CE    1 
ATOM 1801 N NZ    . LYS A 1 284 ? 108.841 135.854 150.885 1.00 55.43  ? 284 LYS A NZ    1 
ATOM 1802 N N     . LEU A 1 285 ? 114.758 133.745 148.308 1.00 50.42  ? 285 LEU A N     1 
ATOM 1803 C CA    . LEU A 1 285 ? 116.068 133.491 147.721 1.00 50.42  ? 285 LEU A CA    1 
ATOM 1804 C C     . LEU A 1 285 ? 116.058 133.718 146.215 1.00 50.42  ? 285 LEU A C     1 
ATOM 1805 O O     . LEU A 1 285 ? 117.117 133.736 145.579 1.00 50.42  ? 285 LEU A O     1 
ATOM 1806 C CB    . LEU A 1 285 ? 116.533 132.065 148.031 1.00 50.42  ? 285 LEU A CB    1 
ATOM 1807 C CG    . LEU A 1 285 ? 117.084 131.761 149.426 1.00 50.42  ? 285 LEU A CG    1 
ATOM 1808 C CD1   . LEU A 1 285 ? 115.989 131.762 150.484 1.00 50.42  ? 285 LEU A CD1   1 
ATOM 1809 C CD2   . LEU A 1 285 ? 117.824 130.432 149.419 1.00 50.42  ? 285 LEU A CD2   1 
ATOM 1810 N N     . LYS A 1 286 ? 114.868 133.885 145.631 1.00 52.89  ? 286 LYS A N     1 
ATOM 1811 C CA    . LYS A 1 286 ? 114.744 134.156 144.204 1.00 52.89  ? 286 LYS A CA    1 
ATOM 1812 C C     . LYS A 1 286 ? 114.274 135.581 143.940 1.00 52.89  ? 286 LYS A C     1 
ATOM 1813 O O     . LYS A 1 286 ? 113.959 135.924 142.796 1.00 52.89  ? 286 LYS A O     1 
ATOM 1814 C CB    . LYS A 1 286 ? 113.799 133.154 143.536 1.00 52.89  ? 286 LYS A CB    1 
ATOM 1815 C CG    . LYS A 1 286 ? 114.351 131.739 143.463 1.00 52.89  ? 286 LYS A CG    1 
ATOM 1816 C CD    . LYS A 1 286 ? 115.658 131.696 142.687 1.00 52.89  ? 286 LYS A CD    1 
ATOM 1817 C CE    . LYS A 1 286 ? 115.438 131.990 141.212 1.00 52.89  ? 286 LYS A CE    1 
ATOM 1818 N NZ    . LYS A 1 286 ? 116.703 131.896 140.433 1.00 52.89  ? 286 LYS A NZ    1 
ATOM 1819 N N     . GLU A 1 287 ? 114.219 136.417 144.977 1.00 51.12  ? 287 GLU A N     1 
ATOM 1820 C CA    . GLU A 1 287 ? 113.931 137.833 144.824 1.00 51.12  ? 287 GLU A CA    1 
ATOM 1821 C C     . GLU A 1 287 ? 115.066 138.733 145.279 1.00 51.12  ? 287 GLU A C     1 
ATOM 1822 O O     . GLU A 1 287 ? 115.229 139.821 144.716 1.00 51.12  ? 287 GLU A O     1 
ATOM 1823 C CB    . GLU A 1 287 ? 112.660 138.216 145.597 1.00 51.12  ? 287 GLU A CB    1 
ATOM 1824 C CG    . GLU A 1 287 ? 111.953 139.445 145.051 1.00 51.12  ? 287 GLU A CG    1 
ATOM 1825 C CD    . GLU A 1 287 ? 110.945 140.018 146.026 1.00 51.12  ? 287 GLU A CD    1 
ATOM 1826 O OE1   . GLU A 1 287 ? 110.836 139.488 147.152 1.00 51.12  ? 287 GLU A OE1   1 
ATOM 1827 O OE2   . GLU A 1 287 ? 110.261 141.000 145.667 1.00 51.12  ? 287 GLU A OE2   1 
ATOM 1828 N N     . ALA A 1 288 ? 115.851 138.319 146.276 1.00 45.78  ? 288 ALA A N     1 
ATOM 1829 C CA    . ALA A 1 288 ? 117.006 139.108 146.683 1.00 45.78  ? 288 ALA A CA    1 
ATOM 1830 C C     . ALA A 1 288 ? 118.090 139.087 145.614 1.00 45.78  ? 288 ALA A C     1 
ATOM 1831 O O     . ALA A 1 288 ? 118.825 140.067 145.447 1.00 45.78  ? 288 ALA A O     1 
ATOM 1832 C CB    . ALA A 1 288 ? 117.551 138.594 148.015 1.00 45.78  ? 288 ALA A CB    1 
ATOM 1833 N N     . ALA A 1 289 ? 118.205 137.977 144.881 1.00 43.78  ? 289 ALA A N     1 
ATOM 1834 C CA    . ALA A 1 289 ? 119.224 137.873 143.845 1.00 43.78  ? 289 ALA A CA    1 
ATOM 1835 C C     . ALA A 1 289 ? 118.924 138.751 142.639 1.00 43.78  ? 289 ALA A C     1 
ATOM 1836 O O     . ALA A 1 289 ? 119.855 139.131 141.920 1.00 43.78  ? 289 ALA A O     1 
ATOM 1837 C CB    . ALA A 1 289 ? 119.377 136.419 143.401 1.00 43.78  ? 289 ALA A CB    1 
ATOM 1838 N N     . LEU A 1 290 ? 117.653 139.080 142.397 1.00 45.63  ? 290 LEU A N     1 
ATOM 1839 C CA    . LEU A 1 290 ? 117.312 139.874 141.220 1.00 45.63  ? 290 LEU A CA    1 
ATOM 1840 C C     . LEU A 1 290 ? 117.749 141.325 141.380 1.00 45.63  ? 290 LEU A C     1 
ATOM 1841 O O     . LEU A 1 290 ? 118.167 141.962 140.406 1.00 45.63  ? 290 LEU A O     1 
ATOM 1842 C CB    . LEU A 1 290 ? 115.811 139.793 140.946 1.00 45.63  ? 290 LEU A CB    1 
ATOM 1843 C CG    . LEU A 1 290 ? 115.279 138.425 140.518 1.00 45.63  ? 290 LEU A CG    1 
ATOM 1844 C CD1   . LEU A 1 290 ? 113.761 138.447 140.415 1.00 45.63  ? 290 LEU A CD1   1 
ATOM 1845 C CD2   . LEU A 1 290 ? 115.903 137.993 139.203 1.00 45.63  ? 290 LEU A CD2   1 
ATOM 1846 N N     . LYS A 1 291 ? 117.657 141.866 142.596 1.00 45.50  ? 291 LYS A N     1 
ATOM 1847 C CA    . LYS A 1 291 ? 118.046 143.255 142.814 1.00 45.50  ? 291 LYS A CA    1 
ATOM 1848 C C     . LYS A 1 291 ? 119.547 143.448 142.635 1.00 45.50  ? 291 LYS A C     1 
ATOM 1849 O O     . LYS A 1 291 ? 119.988 144.483 142.121 1.00 45.50  ? 291 LYS A O     1 
ATOM 1850 C CB    . LYS A 1 291 ? 117.607 143.714 144.204 1.00 45.50  ? 291 LYS A CB    1 
ATOM 1851 C CG    . LYS A 1 291 ? 116.102 143.735 144.404 1.00 45.50  ? 291 LYS A CG    1 
ATOM 1852 C CD    . LYS A 1 291 ? 115.736 144.271 145.778 1.00 45.50  ? 291 LYS A CD    1 
ATOM 1853 C CE    . LYS A 1 291 ? 116.108 143.286 146.874 1.00 45.50  ? 291 LYS A CE    1 
ATOM 1854 N NZ    . LYS A 1 291 ? 115.300 142.038 146.793 1.00 45.50  ? 291 LYS A NZ    1 
ATOM 1855 N N     . GLU A 1 292 ? 120.346 142.469 143.051 1.00 43.70  ? 292 GLU A N     1 
ATOM 1856 C CA    . GLU A 1 292 ? 121.797 142.567 142.962 1.00 43.70  ? 292 GLU A CA    1 
ATOM 1857 C C     . GLU A 1 292 ? 122.359 141.967 141.680 1.00 43.70  ? 292 GLU A C     1 
ATOM 1858 O O     . GLU A 1 292 ? 123.583 141.840 141.562 1.00 43.70  ? 292 GLU A O     1 
ATOM 1859 C CB    . GLU A 1 292 ? 122.444 141.888 144.172 1.00 43.70  ? 292 GLU A CB    1 
ATOM 1860 C CG    . GLU A 1 292 ? 121.836 142.285 145.506 1.00 43.70  ? 292 GLU A CG    1 
ATOM 1861 C CD    . GLU A 1 292 ? 122.711 141.899 146.681 1.00 43.70  ? 292 GLU A CD    1 
ATOM 1862 O OE1   . GLU A 1 292 ? 123.865 141.481 146.451 1.00 43.70  ? 292 GLU A OE1   1 
ATOM 1863 O OE2   . GLU A 1 292 ? 122.246 142.013 147.835 1.00 43.70  ? 292 GLU A OE2   1 
ATOM 1864 N N     . ALA A 1 293 ? 121.510 141.597 140.726 1.00 40.60  ? 293 ALA A N     1 
ATOM 1865 C CA    . ALA A 1 293 ? 121.978 140.948 139.513 1.00 40.60  ? 293 ALA A CA    1 
ATOM 1866 C C     . ALA A 1 293 ? 122.658 141.949 138.582 1.00 40.60  ? 293 ALA A C     1 
ATOM 1867 O O     . ALA A 1 293 ? 122.504 143.166 138.708 1.00 40.60  ? 293 ALA A O     1 
ATOM 1868 C CB    . ALA A 1 293 ? 120.819 140.267 138.788 1.00 40.60  ? 293 ALA A CB    1 
ATOM 1869 N N     . ILE A 1 294 ? 123.422 141.412 137.635 1.00 38.26  ? 294 ILE A N     1 
ATOM 1870 C CA    . ILE A 1 294 ? 124.117 142.216 136.632 1.00 38.26  ? 294 ILE A CA    1 
ATOM 1871 C C     . ILE A 1 294 ? 123.572 141.845 135.258 1.00 38.26  ? 294 ILE A C     1 
ATOM 1872 O O     . ILE A 1 294 ? 124.030 140.865 134.655 1.00 38.26  ? 294 ILE A O     1 
ATOM 1873 C CB    . ILE A 1 294 ? 125.636 142.007 136.702 1.00 38.26  ? 294 ILE A CB    1 
ATOM 1874 C CG1   . ILE A 1 294 ? 126.112 142.041 138.153 1.00 38.26  ? 294 ILE A CG1   1 
ATOM 1875 C CG2   . ILE A 1 294 ? 126.353 143.068 135.887 1.00 38.26  ? 294 ILE A CG2   1 
ATOM 1876 C CD1   . ILE A 1 294 ? 127.614 142.001 138.304 1.00 38.26  ? 294 ILE A CD1   1 
ATOM 1877 N N     . PRO A 1 295 ? 122.605 142.591 134.726 1.00 36.10  ? 295 PRO A N     1 
ATOM 1878 C CA    . PRO A 1 295 ? 121.938 142.191 133.479 1.00 36.10  ? 295 PRO A CA    1 
ATOM 1879 C C     . PRO A 1 295 ? 122.746 142.559 132.244 1.00 36.10  ? 295 PRO A C     1 
ATOM 1880 O O     . PRO A 1 295 ? 123.180 143.704 132.079 1.00 36.10  ? 295 PRO A O     1 
ATOM 1881 C CB    . PRO A 1 295 ? 120.608 142.955 133.541 1.00 36.10  ? 295 PRO A CB    1 
ATOM 1882 C CG    . PRO A 1 295 ? 120.899 144.143 134.375 1.00 36.10  ? 295 PRO A CG    1 
ATOM 1883 C CD    . PRO A 1 295 ? 121.939 143.734 135.373 1.00 36.10  ? 295 PRO A CD    1 
ATOM 1884 N N     . ILE A 1 296 ? 122.951 141.579 131.367 1.00 34.23  ? 296 ILE A N     1 
ATOM 1885 C CA    . ILE A 1 296 ? 123.493 141.788 130.029 1.00 34.23  ? 296 ILE A CA    1 
ATOM 1886 C C     . ILE A 1 296 ? 122.471 141.243 129.038 1.00 34.23  ? 296 ILE A C     1 
ATOM 1887 O O     . ILE A 1 296 ? 121.888 140.175 129.261 1.00 34.23  ? 296 ILE A O     1 
ATOM 1888 C CB    . ILE A 1 296 ? 124.866 141.123 129.854 1.00 34.23  ? 296 ILE A CB    1 
ATOM 1889 C CG1   . ILE A 1 296 ? 124.782 139.616 130.099 1.00 34.23  ? 296 ILE A CG1   1 
ATOM 1890 C CG2   . ILE A 1 296 ? 125.886 141.757 130.786 1.00 34.23  ? 296 ILE A CG2   1 
ATOM 1891 C CD1   . ILE A 1 296 ? 126.041 138.870 129.730 1.00 34.23  ? 296 ILE A CD1   1 
ATOM 1892 N N     . ILE A 1 297 ? 122.233 141.983 127.957 1.00 32.65  ? 297 ILE A N     1 
ATOM 1893 C CA    . ILE A 1 297 ? 121.107 141.731 127.065 1.00 32.65  ? 297 ILE A CA    1 
ATOM 1894 C C     . ILE A 1 297 ? 121.617 141.381 125.673 1.00 32.65  ? 297 ILE A C     1 
ATOM 1895 O O     . ILE A 1 297 ? 122.515 142.047 125.142 1.00 32.65  ? 297 ILE A O     1 
ATOM 1896 C CB    . ILE A 1 297 ? 120.151 142.936 127.019 1.00 32.65  ? 297 ILE A CB    1 
ATOM 1897 C CG1   . ILE A 1 297 ? 119.004 142.681 126.043 1.00 32.65  ? 297 ILE A CG1   1 
ATOM 1898 C CG2   . ILE A 1 297 ? 120.899 144.208 126.670 1.00 32.65  ? 297 ILE A CG2   1 
ATOM 1899 C CD1   . ILE A 1 297 ? 117.914 143.722 126.111 1.00 32.65  ? 297 ILE A CD1   1 
ATOM 1900 N N     . VAL A 1 298 ? 121.053 140.323 125.096 1.00 33.07  ? 298 VAL A N     1 
ATOM 1901 C CA    . VAL A 1 298 ? 121.292 139.933 123.710 1.00 33.07  ? 298 VAL A CA    1 
ATOM 1902 C C     . VAL A 1 298 ? 119.963 140.018 122.973 1.00 33.07  ? 298 VAL A C     1 
ATOM 1903 O O     . VAL A 1 298 ? 118.997 139.340 123.343 1.00 33.07  ? 298 VAL A O     1 
ATOM 1904 C CB    . VAL A 1 298 ? 121.889 138.519 123.624 1.00 33.07  ? 298 VAL A CB    1 
ATOM 1905 C CG1   . VAL A 1 298 ? 121.759 137.968 122.224 1.00 33.07  ? 298 VAL A CG1   1 
ATOM 1906 C CG2   . VAL A 1 298 ? 123.343 138.537 124.045 1.00 33.07  ? 298 VAL A CG2   1 
ATOM 1907 N N     . THR A 1 299 ? 119.904 140.846 121.932 1.00 32.17  ? 299 THR A N     1 
ATOM 1908 C CA    . THR A 1 299 ? 118.652 141.170 121.253 1.00 32.17  ? 299 THR A CA    1 
ATOM 1909 C C     . THR A 1 299 ? 118.743 140.771 119.784 1.00 32.17  ? 299 THR A C     1 
ATOM 1910 O O     . THR A 1 299 ? 119.423 141.436 118.996 1.00 32.17  ? 299 THR A O     1 
ATOM 1911 C CB    . THR A 1 299 ? 118.336 142.658 121.388 1.00 32.17  ? 299 THR A CB    1 
ATOM 1912 O OG1   . THR A 1 299 ? 118.220 143.000 122.775 1.00 32.17  ? 299 THR A OG1   1 
ATOM 1913 C CG2   . THR A 1 299 ? 117.033 142.995 120.679 1.00 32.17  ? 299 THR A CG2   1 
ATOM 1914 N N     . ILE A 1 300 ? 118.037 139.706 119.414 1.00 31.27  ? 300 ILE A N     1 
ATOM 1915 C CA    . ILE A 1 300 ? 117.945 139.260 118.028 1.00 31.27  ? 300 ILE A CA    1 
ATOM 1916 C C     . ILE A 1 300 ? 116.582 139.684 117.498 1.00 31.27  ? 300 ILE A C     1 
ATOM 1917 O O     . ILE A 1 300 ? 115.547 139.180 117.947 1.00 31.27  ? 300 ILE A O     1 
ATOM 1918 C CB    . ILE A 1 300 ? 118.140 137.744 117.896 1.00 31.27  ? 300 ILE A CB    1 
ATOM 1919 C CG1   . ILE A 1 300 ? 119.552 137.343 118.312 1.00 31.27  ? 300 ILE A CG1   1 
ATOM 1920 C CG2   . ILE A 1 300 ? 117.869 137.299 116.470 1.00 31.27  ? 300 ILE A CG2   1 
ATOM 1921 C CD1   . ILE A 1 300 ? 119.796 135.862 118.338 1.00 31.27  ? 300 ILE A CD1   1 
ATOM 1922 N N     . GLY A 1 301 ? 116.579 140.599 116.534 1.00 31.43  ? 301 GLY A N     1 
ATOM 1923 C CA    . GLY A 1 301 ? 115.323 141.065 115.970 1.00 31.43  ? 301 GLY A CA    1 
ATOM 1924 C C     . GLY A 1 301 ? 114.467 141.731 117.027 1.00 31.43  ? 301 GLY A C     1 
ATOM 1925 O O     . GLY A 1 301 ? 114.901 142.660 117.717 1.00 31.43  ? 301 GLY A O     1 
ATOM 1926 N N     . LYS A 1 302 ? 113.233 141.254 117.161 1.00 33.00  ? 302 LYS A N     1 
ATOM 1927 C CA    . LYS A 1 302 ? 112.317 141.738 118.183 1.00 33.00  ? 302 LYS A CA    1 
ATOM 1928 C C     . LYS A 1 302 ? 112.382 140.914 119.462 1.00 33.00  ? 302 LYS A C     1 
ATOM 1929 O O     . LYS A 1 302 ? 111.564 141.125 120.363 1.00 33.00  ? 302 LYS A O     1 
ATOM 1930 C CB    . LYS A 1 302 ? 110.884 141.751 117.645 1.00 33.00  ? 302 LYS A CB    1 
ATOM 1931 C CG    . LYS A 1 302 ? 110.682 142.650 116.440 1.00 33.00  ? 302 LYS A CG    1 
ATOM 1932 C CD    . LYS A 1 302 ? 110.815 144.115 116.815 1.00 33.00  ? 302 LYS A CD    1 
ATOM 1933 C CE    . LYS A 1 302 ? 110.624 145.013 115.605 1.00 33.00  ? 302 LYS A CE    1 
ATOM 1934 N NZ    . LYS A 1 302 ? 109.222 144.978 115.103 1.00 33.00  ? 302 LYS A NZ    1 
ATOM 1935 N N     . ASP A 1 303 ? 113.331 139.989 119.561 1.00 33.64  ? 303 ASP A N     1 
ATOM 1936 C CA    . ASP A 1 303 ? 113.453 139.100 120.708 1.00 33.64  ? 303 ASP A CA    1 
ATOM 1937 C C     . ASP A 1 303 ? 114.743 139.403 121.459 1.00 33.64  ? 303 ASP A C     1 
ATOM 1938 O O     . ASP A 1 303 ? 115.801 139.567 120.843 1.00 33.64  ? 303 ASP A O     1 
ATOM 1939 C CB    . ASP A 1 303 ? 113.424 137.640 120.261 1.00 33.64  ? 303 ASP A CB    1 
ATOM 1940 C CG    . ASP A 1 303 ? 112.015 137.134 120.032 1.00 33.64  ? 303 ASP A CG    1 
ATOM 1941 O OD1   . ASP A 1 303 ? 111.081 137.678 120.657 1.00 33.64  ? 303 ASP A OD1   1 
ATOM 1942 O OD2   . ASP A 1 303 ? 111.840 136.199 119.224 1.00 33.64  ? 303 ASP A OD2   1 
ATOM 1943 N N     . TRP A 1 304 ? 114.650 139.473 122.791 1.00 33.20  ? 304 TRP A N     1 
ATOM 1944 C CA    . TRP A 1 304 ? 115.756 139.906 123.649 1.00 33.20  ? 304 TRP A CA    1 
ATOM 1945 C C     . TRP A 1 304 ? 115.918 138.915 124.801 1.00 33.20  ? 304 TRP A C     1 
ATOM 1946 O O     . TRP A 1 304 ? 114.938 138.433 125.372 1.00 33.20  ? 304 TRP A O     1 
ATOM 1947 C CB    . TRP A 1 304 ? 115.515 141.331 124.145 1.00 33.20  ? 304 TRP A CB    1 
ATOM 1948 C CG    . TRP A 1 304 ? 114.130 141.573 124.670 1.00 33.20  ? 304 TRP A CG    1 
ATOM 1949 C CD1   . TRP A 1 304 ? 113.096 142.156 124.001 1.00 33.20  ? 304 TRP A CD1   1 
ATOM 1950 C CD2   . TRP A 1 304 ? 113.644 141.288 125.987 1.00 33.20  ? 304 TRP A CD2   1 
ATOM 1951 N NE1   . TRP A 1 304 ? 111.988 142.226 124.807 1.00 33.20  ? 304 TRP A NE1   1 
ATOM 1952 C CE2   . TRP A 1 304 ? 112.299 141.703 126.034 1.00 33.20  ? 304 TRP A CE2   1 
ATOM 1953 C CE3   . TRP A 1 304 ? 114.213 140.716 127.129 1.00 33.20  ? 304 TRP A CE3   1 
ATOM 1954 C CZ2   . TRP A 1 304 ? 111.513 141.561 127.175 1.00 33.20  ? 304 TRP A CZ2   1 
ATOM 1955 C CZ3   . TRP A 1 304 ? 113.431 140.574 128.259 1.00 33.20  ? 304 TRP A CZ3   1 
ATOM 1956 C CH2   . TRP A 1 304 ? 112.096 140.995 128.274 1.00 33.20  ? 304 TRP A CH2   1 
ATOM 1957 N N     . ILE A 1 305 ? 117.173 138.584 125.114 1.00 32.55  ? 305 ILE A N     1 
ATOM 1958 C CA    . ILE A 1 305 ? 117.464 137.778 126.292 1.00 32.55  ? 305 ILE A CA    1 
ATOM 1959 C C     . ILE A 1 305 ? 118.282 138.595 127.278 1.00 32.55  ? 305 ILE A C     1 
ATOM 1960 O O     . ILE A 1 305 ? 119.278 139.230 126.913 1.00 32.55  ? 305 ILE A O     1 
ATOM 1961 C CB    . ILE A 1 305 ? 118.207 136.489 125.904 1.00 32.55  ? 305 ILE A CB    1 
ATOM 1962 C CG1   . ILE A 1 305 ? 117.347 135.647 124.974 1.00 32.55  ? 305 ILE A CG1   1 
ATOM 1963 C CG2   . ILE A 1 305 ? 118.581 135.690 127.137 1.00 32.55  ? 305 ILE A CG2   1 
ATOM 1964 C CD1   . ILE A 1 305 ? 116.024 135.257 125.571 1.00 32.55  ? 305 ILE A CD1   1 
ATOM 1965 N N     . VAL A 1 306 ? 117.841 138.607 128.532 1.00 32.43  ? 306 VAL A N     1 
ATOM 1966 C CA    . VAL A 1 306 ? 118.605 139.224 129.610 1.00 32.43  ? 306 VAL A CA    1 
ATOM 1967 C C     . VAL A 1 306 ? 119.223 138.137 130.484 1.00 32.43  ? 306 VAL A C     1 
ATOM 1968 O O     . VAL A 1 306 ? 118.529 137.235 130.947 1.00 32.43  ? 306 VAL A O     1 
ATOM 1969 C CB    . VAL A 1 306 ? 117.730 140.179 130.444 1.00 32.43  ? 306 VAL A CB    1 
ATOM 1970 C CG1   . VAL A 1 306 ? 118.413 140.554 131.749 1.00 32.43  ? 306 VAL A CG1   1 
ATOM 1971 C CG2   . VAL A 1 306 ? 117.394 141.420 129.635 1.00 32.43  ? 306 VAL A CG2   1 
ATOM 1972 N N     . MET A 1 307 ? 120.536 138.216 130.679 1.00 35.27  ? 307 MET A N     1 
ATOM 1973 C CA    . MET A 1 307 ? 121.280 137.189 131.388 1.00 35.27  ? 307 MET A CA    1 
ATOM 1974 C C     . MET A 1 307 ? 121.833 137.777 132.676 1.00 35.27  ? 307 MET A C     1 
ATOM 1975 O O     . MET A 1 307 ? 121.557 138.927 133.031 1.00 35.27  ? 307 MET A O     1 
ATOM 1976 C CB    . MET A 1 307 ? 122.410 136.620 130.523 1.00 35.27  ? 307 MET A CB    1 
ATOM 1977 C CG    . MET A 1 307 ? 121.943 135.760 129.369 1.00 35.27  ? 307 MET A CG    1 
ATOM 1978 S SD    . MET A 1 307 ? 123.159 135.693 128.043 1.00 35.27  ? 307 MET A SD    1 
ATOM 1979 C CE    . MET A 1 307 ? 122.195 136.336 126.681 1.00 35.27  ? 307 MET A CE    1 
ATOM 1980 N N     . ASP A 1 308 ? 122.612 136.963 133.390 1.00 36.97  ? 308 ASP A N     1 
ATOM 1981 C CA    . ASP A 1 308 ? 123.229 137.363 134.655 1.00 36.97  ? 308 ASP A CA    1 
ATOM 1982 C C     . ASP A 1 308 ? 124.748 137.308 134.558 1.00 36.97  ? 308 ASP A C     1 
ATOM 1983 O O     . ASP A 1 308 ? 125.346 136.235 134.597 1.00 36.97  ? 308 ASP A O     1 
ATOM 1984 C CB    . ASP A 1 308 ? 122.766 136.464 135.802 1.00 36.97  ? 308 ASP A CB    1 
ATOM 1985 C CG    . ASP A 1 308 ? 123.180 136.996 137.165 1.00 36.97  ? 308 ASP A CG    1 
ATOM 1986 O OD1   . ASP A 1 308 ? 123.437 138.214 137.281 1.00 36.97  ? 308 ASP A OD1   1 
ATOM 1987 O OD2   . ASP A 1 308 ? 123.238 136.197 138.123 1.00 36.97  ? 308 ASP A OD2   1 
ATOM 1988 N N     . ALA A 1 309 ? 125.361 138.479 134.456 1.00 37.00  ? 309 ALA A N     1 
ATOM 1989 C CA    . ALA A 1 309 ? 126.791 138.603 134.218 1.00 37.00  ? 309 ALA A CA    1 
ATOM 1990 C C     . ALA A 1 309 ? 127.630 138.143 135.400 1.00 37.00  ? 309 ALA A C     1 
ATOM 1991 O O     . ALA A 1 309 ? 128.857 138.070 135.283 1.00 37.00  ? 309 ALA A O     1 
ATOM 1992 C CB    . ALA A 1 309 ? 127.141 140.050 133.865 1.00 37.00  ? 309 ALA A CB    1 
ATOM 1993 N N     . ARG A 1 310 ? 126.999 137.837 136.534 1.00 36.70  ? 310 ARG A N     1 
ATOM 1994 C CA    . ARG A 1 310 ? 127.727 137.383 137.711 1.00 36.70  ? 310 ARG A CA    1 
ATOM 1995 C C     . ARG A 1 310 ? 128.463 136.073 137.471 1.00 36.70  ? 310 ARG A C     1 
ATOM 1996 O O     . ARG A 1 310 ? 129.430 135.785 138.185 1.00 36.70  ? 310 ARG A O     1 
ATOM 1997 C CB    . ARG A 1 310 ? 126.757 137.237 138.883 1.00 36.70  ? 310 ARG A CB    1 
ATOM 1998 C CG    . ARG A 1 310 ? 126.341 138.556 139.508 1.00 36.70  ? 310 ARG A CG    1 
ATOM 1999 C CD    . ARG A 1 310 ? 125.641 138.353 140.838 1.00 36.70  ? 310 ARG A CD    1 
ATOM 2000 N NE    . ARG A 1 310 ? 124.248 137.961 140.656 1.00 36.70  ? 310 ARG A NE    1 
ATOM 2001 C CZ    . ARG A 1 310 ? 123.305 138.091 141.578 1.00 36.70  ? 310 ARG A CZ    1 
ATOM 2002 N NH1   . ARG A 1 310 ? 123.567 138.603 142.769 1.00 36.70  ? 310 ARG A NH1   1 
ATOM 2003 N NH2   . ARG A 1 310 ? 122.065 137.699 141.297 1.00 36.70  ? 310 ARG A NH2   1 
ATOM 2004 N N     . GLY A 1 311 ? 128.040 135.281 136.489 1.00 35.76  ? 311 GLY A N     1 
ATOM 2005 C CA    . GLY A 1 311 ? 128.719 134.041 136.174 1.00 35.76  ? 311 GLY A CA    1 
ATOM 2006 C C     . GLY A 1 311 ? 130.041 134.281 135.481 1.00 35.76  ? 311 GLY A C     1 
ATOM 2007 O O     . GLY A 1 311 ? 130.926 133.421 135.490 1.00 35.76  ? 311 GLY A O     1 
ATOM 2008 N N     . LEU A 1 312 ? 130.182 135.458 134.875 1.00 35.71  ? 312 LEU A N     1 
ATOM 2009 C CA    . LEU A 1 312 ? 131.451 135.882 134.304 1.00 35.71  ? 312 LEU A CA    1 
ATOM 2010 C C     . LEU A 1 312 ? 132.327 136.607 135.311 1.00 35.71  ? 312 LEU A C     1 
ATOM 2011 O O     . LEU A 1 312 ? 133.557 136.523 135.221 1.00 35.71  ? 312 LEU A O     1 
ATOM 2012 C CB    . LEU A 1 312 ? 131.212 136.797 133.101 1.00 35.71  ? 312 LEU A CB    1 
ATOM 2013 C CG    . LEU A 1 312 ? 130.251 136.297 132.027 1.00 35.71  ? 312 LEU A CG    1 
ATOM 2014 C CD1   . LEU A 1 312 ? 129.780 137.449 131.161 1.00 35.71  ? 312 LEU A CD1   1 
ATOM 2015 C CD2   . LEU A 1 312 ? 130.904 135.220 131.185 1.00 35.71  ? 312 LEU A CD2   1 
ATOM 2016 N N     . LEU A 1 313 ? 131.717 137.317 136.261 1.00 37.93  ? 313 LEU A N     1 
ATOM 2017 C CA    . LEU A 1 313 ? 132.483 138.021 137.283 1.00 37.93  ? 313 LEU A CA    1 
ATOM 2018 C C     . LEU A 1 313 ? 133.237 137.045 138.177 1.00 37.93  ? 313 LEU A C     1 
ATOM 2019 O O     . LEU A 1 313 ? 134.383 137.304 138.560 1.00 37.93  ? 313 LEU A O     1 
ATOM 2020 C CB    . LEU A 1 313 ? 131.548 138.905 138.106 1.00 37.93  ? 313 LEU A CB    1 
ATOM 2021 C CG    . LEU A 1 313 ? 132.176 139.929 139.046 1.00 37.93  ? 313 LEU A CG    1 
ATOM 2022 C CD1   . LEU A 1 313 ? 133.021 140.918 138.263 1.00 37.93  ? 313 LEU A CD1   1 
ATOM 2023 C CD2   . LEU A 1 313 ? 131.091 140.648 139.823 1.00 37.93  ? 313 LEU A CD2   1 
ATOM 2024 N N     . ARG A 1 314 ? 132.607 135.923 138.528 1.00 36.37  ? 314 ARG A N     1 
ATOM 2025 C CA    . ARG A 1 314 ? 133.285 134.924 139.347 1.00 36.37  ? 314 ARG A CA    1 
ATOM 2026 C C     . ARG A 1 314 ? 134.457 134.303 138.601 1.00 36.37  ? 314 ARG A C     1 
ATOM 2027 O O     . ARG A 1 314 ? 135.496 134.009 139.203 1.00 36.37  ? 314 ARG A O     1 
ATOM 2028 C CB    . ARG A 1 314 ? 132.301 133.841 139.788 1.00 36.37  ? 314 ARG A CB    1 
ATOM 2029 C CG    . ARG A 1 314 ? 132.646 133.212 141.132 1.00 36.37  ? 314 ARG A CG    1 
ATOM 2030 C CD    . ARG A 1 314 ? 132.129 131.784 141.246 1.00 36.37  ? 314 ARG A CD    1 
ATOM 2031 N NE    . ARG A 1 314 ? 133.055 130.811 140.678 1.00 36.37  ? 314 ARG A NE    1 
ATOM 2032 C CZ    . ARG A 1 314 ? 132.729 129.909 139.763 1.00 36.37  ? 314 ARG A CZ    1 
ATOM 2033 N NH1   . ARG A 1 314 ? 131.501 129.825 139.283 1.00 36.37  ? 314 ARG A NH1   1 
ATOM 2034 N NH2   . ARG A 1 314 ? 133.659 129.069 139.320 1.00 36.37  ? 314 ARG A NH2   1 
ATOM 2035 N N     . ALA A 1 315 ? 134.308 134.097 137.291 1.00 36.46  ? 315 ALA A N     1 
ATOM 2036 C CA    . ALA A 1 315 ? 135.332 133.399 136.520 1.00 36.46  ? 315 ALA A CA    1 
ATOM 2037 C C     . ALA A 1 315 ? 136.653 134.159 136.529 1.00 36.46  ? 315 ALA A C     1 
ATOM 2038 O O     . ALA A 1 315 ? 137.716 133.572 136.757 1.00 36.46  ? 315 ALA A O     1 
ATOM 2039 C CB    . ALA A 1 315 ? 134.844 133.177 135.090 1.00 36.46  ? 315 ALA A CB    1 
ATOM 2040 N N     . VAL A 1 316 ? 136.608 135.470 136.290 1.00 37.47  ? 316 VAL A N     1 
ATOM 2041 C CA    . VAL A 1 316 ? 137.842 136.249 136.234 1.00 37.47  ? 316 VAL A CA    1 
ATOM 2042 C C     . VAL A 1 316 ? 138.472 136.367 137.617 1.00 37.47  ? 316 VAL A C     1 
ATOM 2043 O O     . VAL A 1 316 ? 139.695 136.505 137.745 1.00 37.47  ? 316 VAL A O     1 
ATOM 2044 C CB    . VAL A 1 316 ? 137.578 137.629 135.605 1.00 37.47  ? 316 VAL A CB    1 
ATOM 2045 C CG1   . VAL A 1 316 ? 137.200 137.477 134.142 1.00 37.47  ? 316 VAL A CG1   1 
ATOM 2046 C CG2   . VAL A 1 316 ? 136.486 138.363 136.360 1.00 37.47  ? 316 VAL A CG2   1 
ATOM 2047 N N     . TYR A 1 317 ? 137.655 136.322 138.674 1.00 38.56  ? 317 TYR A N     1 
ATOM 2048 C CA    . TYR A 1 317 ? 138.186 136.470 140.026 1.00 38.56  ? 317 TYR A CA    1 
ATOM 2049 C C     . TYR A 1 317 ? 139.077 135.298 140.418 1.00 38.56  ? 317 TYR A C     1 
ATOM 2050 O O     . TYR A 1 317 ? 140.192 135.499 140.913 1.00 38.56  ? 317 TYR A O     1 
ATOM 2051 C CB    . TYR A 1 317 ? 137.044 136.625 141.029 1.00 38.56  ? 317 TYR A CB    1 
ATOM 2052 C CG    . TYR A 1 317 ? 136.401 137.990 141.030 1.00 38.56  ? 317 TYR A CG    1 
ATOM 2053 C CD1   . TYR A 1 317 ? 137.038 139.080 140.457 1.00 38.56  ? 317 TYR A CD1   1 
ATOM 2054 C CD2   . TYR A 1 317 ? 135.157 138.190 141.612 1.00 38.56  ? 317 TYR A CD2   1 
ATOM 2055 C CE1   . TYR A 1 317 ? 136.454 140.329 140.460 1.00 38.56  ? 317 TYR A CE1   1 
ATOM 2056 C CE2   . TYR A 1 317 ? 134.566 139.435 141.620 1.00 38.56  ? 317 TYR A CE2   1 
ATOM 2057 C CZ    . TYR A 1 317 ? 135.217 140.501 141.043 1.00 38.56  ? 317 TYR A CZ    1 
ATOM 2058 O OH    . TYR A 1 317 ? 134.629 141.745 141.049 1.00 38.56  ? 317 TYR A OH    1 
ATOM 2059 N N     . TRP A 1 318 ? 138.610 134.069 140.213 1.00 36.53  ? 318 TRP A N     1 
ATOM 2060 C CA    . TRP A 1 318 ? 139.355 132.902 140.664 1.00 36.53  ? 318 TRP A CA    1 
ATOM 2061 C C     . TRP A 1 318 ? 140.445 132.483 139.690 1.00 36.53  ? 318 TRP A C     1 
ATOM 2062 O O     . TRP A 1 318 ? 141.209 131.563 139.998 1.00 36.53  ? 318 TRP A O     1 
ATOM 2063 C CB    . TRP A 1 318 ? 138.409 131.722 140.925 1.00 36.53  ? 318 TRP A CB    1 
ATOM 2064 C CG    . TRP A 1 318 ? 137.901 131.022 139.701 1.00 36.53  ? 318 TRP A CG    1 
ATOM 2065 C CD1   . TRP A 1 318 ? 136.824 131.372 138.946 1.00 36.53  ? 318 TRP A CD1   1 
ATOM 2066 C CD2   . TRP A 1 318 ? 138.432 129.828 139.112 1.00 36.53  ? 318 TRP A CD2   1 
ATOM 2067 N NE1   . TRP A 1 318 ? 136.659 130.483 137.913 1.00 36.53  ? 318 TRP A NE1   1 
ATOM 2068 C CE2   . TRP A 1 318 ? 137.633 129.524 137.994 1.00 36.53  ? 318 TRP A CE2   1 
ATOM 2069 C CE3   . TRP A 1 318 ? 139.510 128.992 139.417 1.00 36.53  ? 318 TRP A CE3   1 
ATOM 2070 C CZ2   . TRP A 1 318 ? 137.877 128.422 137.181 1.00 36.53  ? 318 TRP A CZ2   1 
ATOM 2071 C CZ3   . TRP A 1 318 ? 139.750 127.897 138.607 1.00 36.53  ? 318 TRP A CZ3   1 
ATOM 2072 C CH2   . TRP A 1 318 ? 138.937 127.623 137.503 1.00 36.53  ? 318 TRP A CH2   1 
ATOM 2073 N N     . ARG A 1 319 ? 140.543 133.132 138.531 1.00 36.24  ? 319 ARG A N     1 
ATOM 2074 C CA    . ARG A 1 319 ? 141.600 132.845 137.573 1.00 36.24  ? 319 ARG A CA    1 
ATOM 2075 C C     . ARG A 1 319 ? 142.648 133.951 137.518 1.00 36.24  ? 319 ARG A C     1 
ATOM 2076 O O     . ARG A 1 319 ? 143.617 133.835 136.759 1.00 36.24  ? 319 ARG A O     1 
ATOM 2077 C CB    . ARG A 1 319 ? 141.002 132.602 136.185 1.00 36.24  ? 319 ARG A CB    1 
ATOM 2078 C CG    . ARG A 1 319 ? 139.934 131.522 136.180 1.00 36.24  ? 319 ARG A CG    1 
ATOM 2079 C CD    . ARG A 1 319 ? 139.603 131.042 134.780 1.00 36.24  ? 319 ARG A CD    1 
ATOM 2080 N NE    . ARG A 1 319 ? 140.531 130.014 134.329 1.00 36.24  ? 319 ARG A NE    1 
ATOM 2081 C CZ    . ARG A 1 319 ? 140.172 128.929 133.658 1.00 36.24  ? 319 ARG A CZ    1 
ATOM 2082 N NH1   . ARG A 1 319 ? 138.908 128.700 133.341 1.00 36.24  ? 319 ARG A NH1   1 
ATOM 2083 N NH2   . ARG A 1 319 ? 141.103 128.049 133.301 1.00 36.24  ? 319 ARG A NH2   1 
ATOM 2084 N N     . GLY A 1 320 ? 142.483 135.015 138.303 1.00 38.60  ? 320 GLY A N     1 
ATOM 2085 C CA    . GLY A 1 320 ? 143.476 136.055 138.441 1.00 38.60  ? 320 GLY A CA    1 
ATOM 2086 C C     . GLY A 1 320 ? 143.477 137.091 137.337 1.00 38.60  ? 320 GLY A C     1 
ATOM 2087 O O     . GLY A 1 320 ? 144.346 137.970 137.333 1.00 38.60  ? 320 GLY A O     1 
ATOM 2088 N N     . ILE A 1 321 ? 142.532 137.010 136.400 1.00 38.45  ? 321 ILE A N     1 
ATOM 2089 C CA    . ILE A 1 321 ? 142.542 137.924 135.263 1.00 38.45  ? 321 ILE A CA    1 
ATOM 2090 C C     . ILE A 1 321 ? 142.173 139.338 135.697 1.00 38.45  ? 321 ILE A C     1 
ATOM 2091 O O     . ILE A 1 321 ? 142.813 140.313 135.283 1.00 38.45  ? 321 ILE A O     1 
ATOM 2092 C CB    . ILE A 1 321 ? 141.609 137.403 134.157 1.00 38.45  ? 321 ILE A CB    1 
ATOM 2093 C CG1   . ILE A 1 321 ? 142.116 136.058 133.638 1.00 38.45  ? 321 ILE A CG1   1 
ATOM 2094 C CG2   . ILE A 1 321 ? 141.510 138.408 133.021 1.00 38.45  ? 321 ILE A CG2   1 
ATOM 2095 C CD1   . ILE A 1 321 ? 141.162 135.370 132.701 1.00 38.45  ? 321 ILE A CD1   1 
ATOM 2096 N N     . ALA A 1 322 ? 141.148 139.480 136.534 1.00 40.11  ? 322 ALA A N     1 
ATOM 2097 C CA    . ALA A 1 322 ? 140.661 140.802 136.898 1.00 40.11  ? 322 ALA A CA    1 
ATOM 2098 C C     . ALA A 1 322 ? 140.460 140.889 138.404 1.00 40.11  ? 322 ALA A C     1 
ATOM 2099 O O     . ALA A 1 322 ? 140.110 139.903 139.058 1.00 40.11  ? 322 ALA A O     1 
ATOM 2100 C CB    . ALA A 1 322 ? 139.358 141.134 136.166 1.00 40.11  ? 322 ALA A CB    1 
ATOM 2101 N N     . LYS A 1 323 ? 140.685 142.087 138.944 1.00 44.16  ? 323 LYS A N     1 
ATOM 2102 C CA    . LYS A 1 323 ? 140.557 142.341 140.374 1.00 44.16  ? 323 LYS A CA    1 
ATOM 2103 C C     . LYS A 1 323 ? 139.164 142.844 140.729 1.00 44.16  ? 323 LYS A C     1 
ATOM 2104 O O     . LYS A 1 323 ? 138.247 142.789 139.904 1.00 44.16  ? 323 LYS A O     1 
ATOM 2105 C CB    . LYS A 1 323 ? 141.613 143.347 140.834 1.00 44.16  ? 323 LYS A CB    1 
ATOM 2106 C CG    . LYS A 1 323 ? 143.042 142.866 140.648 1.00 44.16  ? 323 LYS A CG    1 
ATOM 2107 C CD    . LYS A 1 323 ? 143.594 142.277 141.936 1.00 44.16  ? 323 LYS A CD    1 
ATOM 2108 C CE    . LYS A 1 323 ? 144.851 141.467 141.678 1.00 44.16  ? 323 LYS A CE    1 
ATOM 2109 N NZ    . LYS A 1 323 ? 144.545 140.207 140.953 1.00 44.16  ? 323 LYS A NZ    1 
ATOM 2110 N N     . PRO A 1 324 ? 139.003 143.341 141.958 1.00 44.29  ? 324 PRO A N     1 
ATOM 2111 C CA    . PRO A 1 324 ? 137.689 143.765 142.414 1.00 44.29  ? 324 PRO A CA    1 
ATOM 2112 C C     . PRO A 1 324 ? 137.120 144.923 141.615 1.00 44.29  ? 324 PRO A C     1 
ATOM 2113 O O     . PRO A 1 324 ? 135.919 144.967 141.340 1.00 44.29  ? 324 PRO A O     1 
ATOM 2114 N N     . GLY A 1 325 ? 137.968 145.872 141.234 1.00 46.32  ? 325 GLY A N     1 
ATOM 2115 C CA    . GLY A 1 325 ? 137.542 147.081 140.533 1.00 46.32  ? 325 GLY A CA    1 
ATOM 2116 C C     . GLY A 1 325 ? 137.644 146.838 139.031 1.00 46.32  ? 325 GLY A C     1 
ATOM 2117 O O     . GLY A 1 325 ? 138.735 146.889 138.456 1.00 46.32  ? 325 GLY A O     1 
ATOM 2118 N N     . LEU A 1 326 ? 136.507 146.545 138.412 1.00 43.78  ? 326 LEU A N     1 
ATOM 2119 C CA    . LEU A 1 326 ? 136.431 146.389 136.968 1.00 43.78  ? 326 LEU A CA    1 
ATOM 2120 C C     . LEU A 1 326 ? 135.105 146.956 136.487 1.00 43.78  ? 326 LEU A C     1 
ATOM 2121 O O     . LEU A 1 326 ? 134.096 146.852 137.179 1.00 43.78  ? 326 LEU A O     1 
ATOM 2122 C CB    . LEU A 1 326 ? 136.577 144.915 136.567 1.00 43.78  ? 326 LEU A CB    1 
ATOM 2123 C CG    . LEU A 1 326 ? 135.599 143.880 137.136 1.00 43.78  ? 326 LEU A CG    1 
ATOM 2124 C CD1   . LEU A 1 326 ? 134.428 143.664 136.195 1.00 43.78  ? 326 LEU A CD1   1 
ATOM 2125 C CD2   . LEU A 1 326 ? 136.303 142.555 137.352 1.00 43.78  ? 326 LEU A CD2   1 
ATOM 2126 N N     . SER A 1 327 ? 135.105 147.554 135.304 1.00 42.40  ? 327 SER A N     1 
ATOM 2127 C CA    . SER A 1 327 ? 133.868 148.049 134.727 1.00 42.40  ? 327 SER A CA    1 
ATOM 2128 C C     . SER A 1 327 ? 133.142 146.923 133.995 1.00 42.40  ? 327 SER A C     1 
ATOM 2129 O O     . SER A 1 327 ? 133.694 145.848 133.743 1.00 42.40  ? 327 SER A O     1 
ATOM 2130 C CB    . SER A 1 327 ? 134.146 149.214 133.779 1.00 42.40  ? 327 SER A CB    1 
ATOM 2131 O OG    . SER A 1 327 ? 134.743 148.764 132.579 1.00 42.40  ? 327 SER A OG    1 
ATOM 2132 N N     . LEU A 1 328 ? 131.878 147.162 133.663 1.00 40.00  ? 328 LEU A N     1 
ATOM 2133 C CA    . LEU A 1 328 ? 131.086 146.155 132.967 1.00 40.00  ? 328 LEU A CA    1 
ATOM 2134 C C     . LEU A 1 328 ? 131.628 145.960 131.554 1.00 40.00  ? 328 LEU A C     1 
ATOM 2135 O O     . LEU A 1 328 ? 131.605 144.854 131.014 1.00 40.00  ? 328 LEU A O     1 
ATOM 2136 C CB    . LEU A 1 328 ? 129.610 146.554 132.936 1.00 40.00  ? 328 LEU A CB    1 
ATOM 2137 C CG    . LEU A 1 328 ? 128.625 145.462 132.513 1.00 40.00  ? 328 LEU A CG    1 
ATOM 2138 C CD1   . LEU A 1 328 ? 128.907 144.170 133.257 1.00 40.00  ? 328 LEU A CD1   1 
ATOM 2139 C CD2   . LEU A 1 328 ? 127.194 145.902 132.751 1.00 40.00  ? 328 LEU A CD2   1 
ATOM 2140 N N     . LYS A 1 329 ? 132.130 147.042 130.969 1.00 40.36  ? 329 LYS A N     1 
ATOM 2141 C CA    . LYS A 1 329 ? 132.725 146.998 129.644 1.00 40.36  ? 329 LYS A CA    1 
ATOM 2142 C C     . LYS A 1 329 ? 133.899 146.025 129.625 1.00 40.36  ? 329 LYS A C     1 
ATOM 2143 O O     . LYS A 1 329 ? 133.987 145.169 128.748 1.00 40.36  ? 329 LYS A O     1 
ATOM 2144 C CB    . LYS A 1 329 ? 133.189 148.394 129.231 1.00 40.36  ? 329 LYS A CB    1 
ATOM 2145 C CG    . LYS A 1 329 ? 133.722 148.481 127.812 1.00 40.36  ? 329 LYS A CG    1 
ATOM 2146 C CD    . LYS A 1 329 ? 134.179 149.892 127.485 1.00 40.36  ? 329 LYS A CD    1 
ATOM 2147 C CE    . LYS A 1 329 ? 134.641 149.998 126.041 1.00 40.36  ? 329 LYS A CE    1 
ATOM 2148 N NZ    . LYS A 1 329 ? 133.551 149.650 125.088 1.00 40.36  ? 329 LYS A NZ    1 
ATOM 2149 N N     . GLU A 1 330 ? 134.794 146.160 130.599 1.00 37.64  ? 330 GLU A N     1 
ATOM 2150 C CA    . GLU A 1 330 ? 135.979 145.313 130.685 1.00 37.64  ? 330 GLU A CA    1 
ATOM 2151 C C     . GLU A 1 330 ? 135.607 143.869 130.989 1.00 37.64  ? 330 GLU A C     1 
ATOM 2152 O O     . GLU A 1 330 ? 136.259 142.940 130.500 1.00 37.64  ? 330 GLU A O     1 
ATOM 2153 C CB    . GLU A 1 330 ? 136.942 145.851 131.743 1.00 37.64  ? 330 GLU A CB    1 
ATOM 2154 C CG    . GLU A 1 330 ? 137.304 147.312 131.571 1.00 37.64  ? 330 GLU A CG    1 
ATOM 2155 C CD    . GLU A 1 330 ? 138.215 147.818 132.670 1.00 37.64  ? 330 GLU A CD    1 
ATOM 2156 O OE1   . GLU A 1 330 ? 138.465 147.063 133.631 1.00 37.64  ? 330 GLU A OE1   1 
ATOM 2157 O OE2   . GLU A 1 330 ? 138.679 148.972 132.574 1.00 37.64  ? 330 GLU A OE2   1 
ATOM 2158 N N     . LEU A 1 331 ? 134.571 143.661 131.803 1.00 37.62  ? 331 LEU A N     1 
ATOM 2159 C CA    . LEU A 1 331 ? 134.120 142.303 132.090 1.00 37.62  ? 331 LEU A CA    1 
ATOM 2160 C C     . LEU A 1 331 ? 133.636 141.612 130.821 1.00 37.62  ? 331 LEU A C     1 
ATOM 2161 O O     . LEU A 1 331 ? 134.030 140.479 130.528 1.00 37.62  ? 331 LEU A O     1 
ATOM 2162 C CB    . LEU A 1 331 ? 133.018 142.329 133.148 1.00 37.62  ? 331 LEU A CB    1 
ATOM 2163 C CG    . LEU A 1 331 ? 132.294 141.004 133.382 1.00 37.62  ? 331 LEU A CG    1 
ATOM 2164 C CD1   . LEU A 1 331 ? 133.103 140.122 134.317 1.00 37.62  ? 331 LEU A CD1   1 
ATOM 2165 C CD2   . LEU A 1 331 ? 130.908 141.241 133.942 1.00 37.62  ? 331 LEU A CD2   1 
ATOM 2166 N N     . LEU A 1 332 ? 132.783 142.286 130.052 1.00 35.82  ? 332 LEU A N     1 
ATOM 2167 C CA    . LEU A 1 332 ? 132.325 141.761 128.773 1.00 35.82  ? 332 LEU A CA    1 
ATOM 2168 C C     . LEU A 1 332 ? 133.412 141.769 127.707 1.00 35.82  ? 332 LEU A C     1 
ATOM 2169 O O     . LEU A 1 332 ? 133.294 141.035 126.720 1.00 35.82  ? 332 LEU A O     1 
ATOM 2170 C CB    . LEU A 1 332 ? 131.117 142.559 128.278 1.00 35.82  ? 332 LEU A CB    1 
ATOM 2171 C CG    . LEU A 1 332 ? 129.794 142.343 129.014 1.00 35.82  ? 332 LEU A CG    1 
ATOM 2172 C CD1   . LEU A 1 332 ? 128.786 143.413 128.627 1.00 35.82  ? 332 LEU A CD1   1 
ATOM 2173 C CD2   . LEU A 1 332 ? 129.246 140.960 128.722 1.00 35.82  ? 332 LEU A CD2   1 
ATOM 2174 N N     . GLY A 1 333 ? 134.460 142.570 127.879 1.00 35.59  ? 333 GLY A N     1 
ATOM 2175 C CA    . GLY A 1 333 ? 135.555 142.643 126.939 1.00 35.59  ? 333 GLY A CA    1 
ATOM 2176 C C     . GLY A 1 333 ? 136.602 141.566 127.081 1.00 35.59  ? 333 GLY A C     1 
ATOM 2177 O O     . GLY A 1 333 ? 137.533 141.507 126.271 1.00 35.59  ? 333 GLY A O     1 
ATOM 2178 N N     . PHE A 1 334 ? 136.484 140.706 128.092 1.00 34.48  ? 334 PHE A N     1 
ATOM 2179 C CA    . PHE A 1 334 ? 137.388 139.580 128.283 1.00 34.48  ? 334 PHE A CA    1 
ATOM 2180 C C     . PHE A 1 334 ? 136.866 138.313 127.618 1.00 34.48  ? 334 PHE A C     1 
ATOM 2181 O O     . PHE A 1 334 ? 137.505 137.260 127.703 1.00 34.48  ? 334 PHE A O     1 
ATOM 2182 C CB    . PHE A 1 334 ? 137.620 139.338 129.775 1.00 34.48  ? 334 PHE A CB    1 
ATOM 2183 C CG    . PHE A 1 334 ? 138.626 140.266 130.395 1.00 34.48  ? 334 PHE A CG    1 
ATOM 2184 C CD1   . PHE A 1 334 ? 139.606 140.865 129.622 1.00 34.48  ? 334 PHE A CD1   1 
ATOM 2185 C CD2   . PHE A 1 334 ? 138.588 140.542 131.750 1.00 34.48  ? 334 PHE A CD2   1 
ATOM 2186 C CE1   . PHE A 1 334 ? 140.532 141.717 130.192 1.00 34.48  ? 334 PHE A CE1   1 
ATOM 2187 C CE2   . PHE A 1 334 ? 139.509 141.391 132.323 1.00 34.48  ? 334 PHE A CE2   1 
ATOM 2188 C CZ    . PHE A 1 334 ? 140.482 141.980 131.544 1.00 34.48  ? 334 PHE A CZ    1 
ATOM 2189 N N     . PHE A 1 335 ? 135.719 138.400 126.951 1.00 34.87  ? 335 PHE A N     1 
ATOM 2190 C CA    . PHE A 1 335 ? 135.038 137.245 126.391 1.00 34.87  ? 335 PHE A CA    1 
ATOM 2191 C C     . PHE A 1 335 ? 134.681 137.508 124.937 1.00 34.87  ? 335 PHE A C     1 
ATOM 2192 O O     . PHE A 1 335 ? 134.635 138.654 124.481 1.00 34.87  ? 335 PHE A O     1 
ATOM 2193 C CB    . PHE A 1 335 ? 133.770 136.910 127.186 1.00 34.87  ? 335 PHE A CB    1 
ATOM 2194 C CG    . PHE A 1 335 ? 134.021 136.666 128.640 1.00 34.87  ? 335 PHE A CG    1 
ATOM 2195 C CD1   . PHE A 1 335 ? 134.747 135.565 129.054 1.00 34.87  ? 335 PHE A CD1   1 
ATOM 2196 C CD2   . PHE A 1 335 ? 133.557 137.552 129.593 1.00 34.87  ? 335 PHE A CD2   1 
ATOM 2197 C CE1   . PHE A 1 335 ? 134.987 135.342 130.391 1.00 34.87  ? 335 PHE A CE1   1 
ATOM 2198 C CE2   . PHE A 1 335 ? 133.801 137.337 130.931 1.00 34.87  ? 335 PHE A CE2   1 
ATOM 2199 C CZ    . PHE A 1 335 ? 134.514 136.229 131.331 1.00 34.87  ? 335 PHE A CZ    1 
ATOM 2200 N N     . SER A 1 336 ? 134.429 136.423 124.212 1.00 35.71  ? 336 SER A N     1 
ATOM 2201 C CA    . SER A 1 336 ? 133.999 136.531 122.830 1.00 35.71  ? 336 SER A CA    1 
ATOM 2202 C C     . SER A 1 336 ? 132.614 137.163 122.751 1.00 35.71  ? 336 SER A C     1 
ATOM 2203 O O     . SER A 1 336 ? 131.796 137.057 123.668 1.00 35.71  ? 336 SER A O     1 
ATOM 2204 C CB    . SER A 1 336 ? 133.986 135.159 122.161 1.00 35.71  ? 336 SER A CB    1 
ATOM 2205 O OG    . SER A 1 336 ? 135.242 134.518 122.292 1.00 35.71  ? 336 SER A OG    1 
ATOM 2206 N N     . GLY A 1 337 ? 132.357 137.827 121.631 1.00 35.75  ? 337 GLY A N     1 
ATOM 2207 C CA    . GLY A 1 337 ? 131.081 138.475 121.414 1.00 35.75  ? 337 GLY A CA    1 
ATOM 2208 C C     . GLY A 1 337 ? 130.072 137.537 120.790 1.00 35.75  ? 337 GLY A C     1 
ATOM 2209 O O     . GLY A 1 337 ? 129.061 137.977 120.237 1.00 35.75  ? 337 GLY A O     1 
ATOM 2210 N N     . ASP A 1 338 ? 130.341 136.235 120.872 1.00 36.18  ? 338 ASP A N     1 
ATOM 2211 C CA    . ASP A 1 338 ? 129.498 135.206 120.267 1.00 36.18  ? 338 ASP A CA    1 
ATOM 2212 C C     . ASP A 1 338 ? 129.143 134.150 121.308 1.00 36.18  ? 338 ASP A C     1 
ATOM 2213 O O     . ASP A 1 338 ? 129.721 133.057 121.320 1.00 36.18  ? 338 ASP A O     1 
ATOM 2214 C CB    . ASP A 1 338 ? 130.210 134.569 119.074 1.00 36.18  ? 338 ASP A CB    1 
ATOM 2215 C CG    . ASP A 1 338 ? 130.375 135.528 117.920 1.00 36.18  ? 338 ASP A CG    1 
ATOM 2216 O OD1   . ASP A 1 338 ? 131.525 135.842 117.559 1.00 36.18  ? 338 ASP A OD1   1 
ATOM 2217 O OD2   . ASP A 1 338 ? 129.356 135.990 117.386 1.00 36.18  ? 338 ASP A OD2   1 
ATOM 2218 N N     . PRO A 1 339 ? 128.205 134.448 122.210 1.00 34.49  ? 339 PRO A N     1 
ATOM 2219 C CA    . PRO A 1 339 ? 127.756 133.427 123.162 1.00 34.49  ? 339 PRO A CA    1 
ATOM 2220 C C     . PRO A 1 339 ? 127.187 132.204 122.458 1.00 34.49  ? 339 PRO A C     1 
ATOM 2221 O O     . PRO A 1 339 ? 126.861 132.223 121.269 1.00 34.49  ? 339 PRO A O     1 
ATOM 2222 C CB    . PRO A 1 339 ? 126.662 134.142 123.968 1.00 34.49  ? 339 PRO A CB    1 
ATOM 2223 C CG    . PRO A 1 339 ? 126.713 135.591 123.564 1.00 34.49  ? 339 PRO A CG    1 
ATOM 2224 C CD    . PRO A 1 339 ? 127.919 135.798 122.717 1.00 34.49  ? 339 PRO A CD    1 
ATOM 2225 N N     . VAL A 1 340 ? 127.068 131.124 123.222 1.00 33.58  ? 340 VAL A N     1 
ATOM 2226 C CA    . VAL A 1 340 ? 126.365 129.930 122.790 1.00 33.58  ? 340 VAL A CA    1 
ATOM 2227 C C     . VAL A 1 340 ? 125.210 129.693 123.754 1.00 33.58  ? 340 VAL A C     1 
ATOM 2228 O O     . VAL A 1 340 ? 125.357 129.771 124.976 1.00 33.58  ? 340 VAL A O     1 
ATOM 2229 C CB    . VAL A 1 340 ? 127.300 128.700 122.718 1.00 33.58  ? 340 VAL A CB    1 
ATOM 2230 C CG1   . VAL A 1 340 ? 126.526 127.464 122.288 1.00 33.58  ? 340 VAL A CG1   1 
ATOM 2231 C CG2   . VAL A 1 340 ? 128.453 128.967 121.769 1.00 33.58  ? 340 VAL A CG2   1 
ATOM 2232 N N     . LEU A 1 341 ? 124.037 129.400 123.199 1.00 33.91  ? 341 LEU A N     1 
ATOM 2233 C CA    . LEU A 1 341 ? 122.817 129.323 123.989 1.00 33.91  ? 341 LEU A CA    1 
ATOM 2234 C C     . LEU A 1 341 ? 122.308 127.890 124.017 1.00 33.91  ? 341 LEU A C     1 
ATOM 2235 O O     . LEU A 1 341 ? 122.419 127.147 123.039 1.00 33.91  ? 341 LEU A O     1 
ATOM 2236 C CB    . LEU A 1 341 ? 121.731 130.256 123.437 1.00 33.91  ? 341 LEU A CB    1 
ATOM 2237 C CG    . LEU A 1 341 ? 122.108 131.730 123.277 1.00 33.91  ? 341 LEU A CG    1 
ATOM 2238 C CD1   . LEU A 1 341 ? 121.023 132.479 122.521 1.00 33.91  ? 341 LEU A CD1   1 
ATOM 2239 C CD2   . LEU A 1 341 ? 122.359 132.372 124.628 1.00 33.91  ? 341 LEU A CD2   1 
ATOM 2240 N N     . ASP A 1 342 ? 121.745 127.512 125.160 1.00 36.12  ? 342 ASP A N     1 
ATOM 2241 C CA    . ASP A 1 342 ? 121.142 126.193 125.345 1.00 36.12  ? 342 ASP A CA    1 
ATOM 2242 C C     . ASP A 1 342 ? 119.675 126.364 125.708 1.00 36.12  ? 342 ASP A C     1 
ATOM 2243 O O     . ASP A 1 342 ? 119.358 126.609 126.888 1.00 36.12  ? 342 ASP A O     1 
ATOM 2244 C CB    . ASP A 1 342 ? 121.875 125.404 126.429 1.00 36.12  ? 342 ASP A CB    1 
ATOM 2245 C CG    . ASP A 1 342 ? 122.022 123.936 126.082 1.00 36.12  ? 342 ASP A CG    1 
ATOM 2246 O OD1   . ASP A 1 342 ? 121.432 123.500 125.072 1.00 36.12  ? 342 ASP A OD1   1 
ATOM 2247 O OD2   . ASP A 1 342 ? 122.730 123.218 126.819 1.00 36.12  ? 342 ASP A OD2   1 
ATOM 2248 N N     . PRO A 1 343 ? 118.755 126.262 124.745 1.00 34.58  ? 343 PRO A N     1 
ATOM 2249 C CA    . PRO A 1 343 ? 117.337 126.505 125.058 1.00 34.58  ? 343 PRO A CA    1 
ATOM 2250 C C     . PRO A 1 343 ? 116.771 125.584 126.124 1.00 34.58  ? 343 PRO A C     1 
ATOM 2251 O O     . PRO A 1 343 ? 115.964 126.026 126.950 1.00 34.58  ? 343 PRO A O     1 
ATOM 2252 C CB    . PRO A 1 343 ? 116.653 126.286 123.702 1.00 34.58  ? 343 PRO A CB    1 
ATOM 2253 C CG    . PRO A 1 343 ? 117.715 126.600 122.706 1.00 34.58  ? 343 PRO A CG    1 
ATOM 2254 C CD    . PRO A 1 343 ? 118.959 126.018 123.310 1.00 34.58  ? 343 PRO A CD    1 
ATOM 2255 N N     . LYS A 1 344 ? 117.170 124.310 126.129 1.00 38.87  ? 344 LYS A N     1 
ATOM 2256 C CA    . LYS A 1 344 ? 116.582 123.354 127.062 1.00 38.87  ? 344 LYS A CA    1 
ATOM 2257 C C     . LYS A 1 344 ? 117.022 123.631 128.494 1.00 38.87  ? 344 LYS A C     1 
ATOM 2258 O O     . LYS A 1 344 ? 116.200 123.629 129.418 1.00 38.87  ? 344 LYS A O     1 
ATOM 2259 C CB    . LYS A 1 344 ? 116.946 121.928 126.650 1.00 38.87  ? 344 LYS A CB    1 
ATOM 2260 C CG    . LYS A 1 344 ? 117.120 121.739 125.152 1.00 38.87  ? 344 LYS A CG    1 
ATOM 2261 C CD    . LYS A 1 344 ? 117.546 120.318 124.819 1.00 38.87  ? 344 LYS A CD    1 
ATOM 2262 C CE    . LYS A 1 344 ? 118.906 119.993 125.415 1.00 38.87  ? 344 LYS A CE    1 
ATOM 2263 N NZ    . LYS A 1 344 ? 119.984 120.833 124.825 1.00 38.87  ? 344 LYS A NZ    1 
ATOM 2264 N N     . ARG A 1 345 ? 118.317 123.873 128.700 1.00 36.30  ? 345 ARG A N     1 
ATOM 2265 C CA    . ARG A 1 345 ? 118.817 124.079 130.055 1.00 36.30  ? 345 ARG A CA    1 
ATOM 2266 C C     . ARG A 1 345 ? 118.463 125.468 130.574 1.00 36.30  ? 345 ARG A C     1 
ATOM 2267 O O     . ARG A 1 345 ? 118.192 125.639 131.768 1.00 36.30  ? 345 ARG A O     1 
ATOM 2268 C CB    . ARG A 1 345 ? 120.328 123.857 130.096 1.00 36.30  ? 345 ARG A CB    1 
ATOM 2269 C CG    . ARG A 1 345 ? 120.744 122.420 129.838 1.00 36.30  ? 345 ARG A CG    1 
ATOM 2270 C CD    . ARG A 1 345 ? 122.247 122.249 129.924 1.00 36.30  ? 345 ARG A CD    1 
ATOM 2271 N NE    . ARG A 1 345 ? 122.658 120.891 129.587 1.00 36.30  ? 345 ARG A NE    1 
ATOM 2272 C CZ    . ARG A 1 345 ? 122.754 119.899 130.460 1.00 36.30  ? 345 ARG A CZ    1 
ATOM 2273 N NH1   . ARG A 1 345 ? 122.479 120.076 131.742 1.00 36.30  ? 345 ARG A NH1   1 
ATOM 2274 N NH2   . ARG A 1 345 ? 123.135 118.697 130.037 1.00 36.30  ? 345 ARG A NH2   1 
ATOM 2275 N N     . GLY A 1 346 ? 118.455 126.468 129.697 1.00 35.40  ? 346 GLY A N     1 
ATOM 2276 C CA    . GLY A 1 346 ? 118.249 127.838 130.123 1.00 35.40  ? 346 GLY A CA    1 
ATOM 2277 C C     . GLY A 1 346 ? 119.546 128.463 130.588 1.00 35.40  ? 346 GLY A C     1 
ATOM 2278 O O     . GLY A 1 346 ? 119.611 129.065 131.664 1.00 35.40  ? 346 GLY A O     1 
ATOM 2279 N N     . ILE A 1 347 ? 120.592 128.320 129.776 1.00 33.12  ? 347 ILE A N     1 
ATOM 2280 C CA    . ILE A 1 347 ? 121.933 128.748 130.152 1.00 33.12  ? 347 ILE A CA    1 
ATOM 2281 C C     . ILE A 1 347 ? 122.611 129.298 128.907 1.00 33.12  ? 347 ILE A C     1 
ATOM 2282 O O     . ILE A 1 347 ? 122.249 128.953 127.781 1.00 33.12  ? 347 ILE A O     1 
ATOM 2283 C CB    . ILE A 1 347 ? 122.728 127.569 130.773 1.00 33.12  ? 347 ILE A CB    1 
ATOM 2284 C CG1   . ILE A 1 347 ? 124.034 128.050 131.407 1.00 33.12  ? 347 ILE A CG1   1 
ATOM 2285 C CG2   . ILE A 1 347 ? 123.005 126.500 129.730 1.00 33.12  ? 347 ILE A CG2   1 
ATOM 2286 C CD1   . ILE A 1 347 ? 124.689 127.019 132.297 1.00 33.12  ? 347 ILE A CD1   1 
ATOM 2287 N N     . ALA A 1 348 ? 123.593 130.173 129.108 1.00 31.87  ? 348 ALA A N     1 
ATOM 2288 C CA    . ALA A 1 348 ? 124.388 130.717 128.017 1.00 31.87  ? 348 ALA A CA    1 
ATOM 2289 C C     . ALA A 1 348 ? 125.858 130.501 128.332 1.00 31.87  ? 348 ALA A C     1 
ATOM 2290 O O     . ALA A 1 348 ? 126.306 130.802 129.442 1.00 31.87  ? 348 ALA A O     1 
ATOM 2291 C CB    . ALA A 1 348 ? 124.101 132.206 127.802 1.00 31.87  ? 348 ALA A CB    1 
ATOM 2292 N N     . THR A 1 349 ? 126.602 129.985 127.360 1.00 32.58  ? 349 THR A N     1 
ATOM 2293 C CA    . THR A 1 349 ? 127.998 129.602 127.547 1.00 32.58  ? 349 THR A CA    1 
ATOM 2294 C C     . THR A 1 349 ? 128.891 130.610 126.831 1.00 32.58  ? 349 THR A C     1 
ATOM 2295 O O     . THR A 1 349 ? 128.997 130.597 125.601 1.00 32.58  ? 349 THR A O     1 
ATOM 2296 C CB    . THR A 1 349 ? 128.245 128.187 127.035 1.00 32.58  ? 349 THR A CB    1 
ATOM 2297 O OG1   . THR A 1 349 ? 127.416 127.265 127.754 1.00 32.58  ? 349 THR A OG1   1 
ATOM 2298 C CG2   . THR A 1 349 ? 129.704 127.800 127.227 1.00 32.58  ? 349 THR A CG2   1 
ATOM 2299 N N     . PHE A 1 350 ? 129.530 131.483 127.604 1.00 32.09  ? 350 PHE A N     1 
ATOM 2300 C CA    . PHE A 1 350 ? 130.532 132.387 127.067 1.00 32.09  ? 350 PHE A CA    1 
ATOM 2301 C C     . PHE A 1 350 ? 131.890 131.696 126.997 1.00 32.09  ? 350 PHE A C     1 
ATOM 2302 O O     . PHE A 1 350 ? 132.143 130.690 127.664 1.00 32.09  ? 350 PHE A O     1 
ATOM 2303 C CB    . PHE A 1 350 ? 130.641 133.648 127.921 1.00 32.09  ? 350 PHE A CB    1 
ATOM 2304 C CG    . PHE A 1 350 ? 129.513 134.617 127.727 1.00 32.09  ? 350 PHE A CG    1 
ATOM 2305 C CD1   . PHE A 1 350 ? 128.276 134.388 128.301 1.00 32.09  ? 350 PHE A CD1   1 
ATOM 2306 C CD2   . PHE A 1 350 ? 129.696 135.768 126.984 1.00 32.09  ? 350 PHE A CD2   1 
ATOM 2307 C CE1   . PHE A 1 350 ? 127.242 135.282 128.125 1.00 32.09  ? 350 PHE A CE1   1 
ATOM 2308 C CE2   . PHE A 1 350 ? 128.667 136.664 126.807 1.00 32.09  ? 350 PHE A CE2   1 
ATOM 2309 C CZ    . PHE A 1 350 ? 127.439 136.423 127.380 1.00 32.09  ? 350 PHE A CZ    1 
ATOM 2310 N N     . THR A 1 351 ? 132.773 132.256 126.173 1.00 34.40  ? 351 THR A N     1 
ATOM 2311 C CA    . THR A 1 351 ? 134.136 131.766 126.039 1.00 34.40  ? 351 THR A CA    1 
ATOM 2312 C C     . THR A 1 351 ? 135.094 132.938 126.194 1.00 34.40  ? 351 THR A C     1 
ATOM 2313 O O     . THR A 1 351 ? 134.726 134.099 126.003 1.00 34.40  ? 351 THR A O     1 
ATOM 2314 C CB    . THR A 1 351 ? 134.363 131.065 124.692 1.00 34.40  ? 351 THR A CB    1 
ATOM 2315 O OG1   . THR A 1 351 ? 134.112 131.985 123.622 1.00 34.40  ? 351 THR A OG1   1 
ATOM 2316 C CG2   . THR A 1 351 ? 133.443 129.861 124.549 1.00 34.40  ? 351 THR A CG2   1 
ATOM 2317 N N     . PHE A 1 352 ? 136.341 132.623 126.537 1.00 34.22  ? 352 PHE A N     1 
ATOM 2318 C CA    . PHE A 1 352 ? 137.359 133.643 126.752 1.00 34.22  ? 352 PHE A CA    1 
ATOM 2319 C C     . PHE A 1 352 ? 138.003 134.046 125.431 1.00 34.22  ? 352 PHE A C     1 
ATOM 2320 O O     . PHE A 1 352 ? 137.493 133.710 124.357 1.00 34.22  ? 352 PHE A O     1 
ATOM 2321 C CB    . PHE A 1 352 ? 138.424 133.136 127.727 1.00 34.22  ? 352 PHE A CB    1 
ATOM 2322 C CG    . PHE A 1 352 ? 138.024 133.235 129.172 1.00 34.22  ? 352 PHE A CG    1 
ATOM 2323 C CD1   . PHE A 1 352 ? 138.544 134.225 129.986 1.00 34.22  ? 352 PHE A CD1   1 
ATOM 2324 C CD2   . PHE A 1 352 ? 137.128 132.332 129.718 1.00 34.22  ? 352 PHE A CD2   1 
ATOM 2325 C CE1   . PHE A 1 352 ? 138.173 134.312 131.315 1.00 34.22  ? 352 PHE A CE1   1 
ATOM 2326 C CE2   . PHE A 1 352 ? 136.757 132.416 131.046 1.00 34.22  ? 352 PHE A CE2   1 
ATOM 2327 C CZ    . PHE A 1 352 ? 137.282 133.406 131.844 1.00 34.22  ? 352 PHE A CZ    1 
ATOM 2328 N N     . LYS A 1 353 ? 139.117 134.772 125.497 1.00 32.88  ? 353 LYS A N     1 
ATOM 2329 C CA    . LYS A 1 353 ? 139.888 135.116 124.311 1.00 32.88  ? 353 LYS A CA    1 
ATOM 2330 C C     . LYS A 1 353 ? 141.247 134.434 124.402 1.00 32.88  ? 353 LYS A C     1 
ATOM 2331 O O     . LYS A 1 353 ? 141.520 133.669 125.330 1.00 32.88  ? 353 LYS A O     1 
ATOM 2332 C CB    . LYS A 1 353 ? 140.024 136.633 124.154 1.00 32.88  ? 353 LYS A CB    1 
ATOM 2333 C CG    . LYS A 1 353 ? 138.704 137.348 123.926 1.00 32.88  ? 353 LYS A CG    1 
ATOM 2334 C CD    . LYS A 1 353 ? 138.920 138.763 123.420 1.00 32.88  ? 353 LYS A CD    1 
ATOM 2335 C CE    . LYS A 1 353 ? 137.631 139.566 123.455 1.00 32.88  ? 353 LYS A CE    1 
ATOM 2336 N NZ    . LYS A 1 353 ? 137.695 140.761 122.573 1.00 32.88  ? 353 LYS A NZ    1 
ATOM 2337 N N     . LEU A 1 354 ? 142.107 134.722 123.421 1.00 34.42  ? 354 LEU A N     1 
ATOM 2338 C CA    . LEU A 1 354 ? 143.401 134.050 123.344 1.00 34.42  ? 354 LEU A CA    1 
ATOM 2339 C C     . LEU A 1 354 ? 144.324 134.449 124.488 1.00 34.42  ? 354 LEU A C     1 
ATOM 2340 O O     . LEU A 1 354 ? 145.301 133.746 124.768 1.00 34.42  ? 354 LEU A O     1 
ATOM 2341 C CB    . LEU A 1 354 ? 144.071 134.339 121.999 1.00 34.42  ? 354 LEU A CB    1 
ATOM 2342 C CG    . LEU A 1 354 ? 143.677 133.483 120.788 1.00 34.42  ? 354 LEU A CG    1 
ATOM 2343 C CD1   . LEU A 1 354 ? 144.064 132.028 121.017 1.00 34.42  ? 354 LEU A CD1   1 
ATOM 2344 C CD2   . LEU A 1 354 ? 142.198 133.601 120.443 1.00 34.42  ? 354 LEU A CD2   1 
ATOM 2345 N N     . GLY A 1 355 ? 144.042 135.563 125.154 1.00 32.19  ? 355 GLY A N     1 
ATOM 2346 C CA    . GLY A 1 355 ? 144.853 135.998 126.276 1.00 32.19  ? 355 GLY A CA    1 
ATOM 2347 C C     . GLY A 1 355 ? 144.087 136.056 127.584 1.00 32.19  ? 355 GLY A C     1 
ATOM 2348 O O     . GLY A 1 355 ? 144.171 135.146 128.407 1.00 32.19  ? 355 GLY A O     1 
ATOM 2349 P P     . DG  B 2 21  ? 114.237 97.452  126.177 1.00 130.16 ? -12 DG  C P     1 
ATOM 2350 O OP1   . DG  B 2 21  ? 114.162 96.762  127.484 1.00 130.16 ? -12 DG  C OP1   1 
ATOM 2351 O OP2   . DG  B 2 21  ? 112.996 97.904  125.510 1.00 130.16 ? -12 DG  C OP2   1 
ATOM 2352 O "O5'" . DG  B 2 21  ? 115.216 98.712  126.311 1.00 130.16 ? -12 DG  C "O5'" 1 
ATOM 2353 C "C5'" . DG  B 2 21  ? 114.736 100.024 126.030 1.00 130.16 ? -12 DG  C "C5'" 1 
ATOM 2354 C "C4'" . DG  B 2 21  ? 114.188 100.684 127.285 1.00 130.16 ? -12 DG  C "C4'" 1 
ATOM 2355 O "O4'" . DG  B 2 21  ? 113.987 99.678  128.311 1.00 130.16 ? -12 DG  C "O4'" 1 
ATOM 2356 C "C3'" . DG  B 2 21  ? 115.092 101.749 127.901 1.00 130.16 ? -12 DG  C "C3'" 1 
ATOM 2357 O "O3'" . DG  B 2 21  ? 114.708 103.041 127.407 1.00 130.16 ? -12 DG  C "O3'" 1 
ATOM 2358 C "C2'" . DG  B 2 21  ? 114.826 101.599 129.399 1.00 130.16 ? -12 DG  C "C2'" 1 
ATOM 2359 C "C1'" . DG  B 2 21  ? 114.550 100.104 129.534 1.00 130.16 ? -12 DG  C "C1'" 1 
ATOM 2360 N N9    . DG  B 2 21  ? 115.738 99.292  129.805 1.00 130.16 ? -12 DG  C N9    1 
ATOM 2361 C C8    . DG  B 2 21  ? 116.790 99.046  128.953 1.00 130.16 ? -12 DG  C C8    1 
ATOM 2362 N N7    . DG  B 2 21  ? 117.706 98.275  129.466 1.00 130.16 ? -12 DG  C N7    1 
ATOM 2363 C C5    . DG  B 2 21  ? 117.231 97.981  130.737 1.00 130.16 ? -12 DG  C C5    1 
ATOM 2364 C C6    . DG  B 2 21  ? 117.798 97.184  131.760 1.00 130.16 ? -12 DG  C C6    1 
ATOM 2365 O O6    . DG  B 2 21  ? 118.869 96.560  131.742 1.00 130.16 ? -12 DG  C O6    1 
ATOM 2366 N N1    . DG  B 2 21  ? 116.991 97.150  132.894 1.00 130.16 ? -12 DG  C N1    1 
ATOM 2367 C C2    . DG  B 2 21  ? 115.787 97.802  133.022 1.00 130.16 ? -12 DG  C C2    1 
ATOM 2368 N N2    . DG  B 2 21  ? 115.151 97.650  134.193 1.00 130.16 ? -12 DG  C N2    1 
ATOM 2369 N N3    . DG  B 2 21  ? 115.244 98.552  132.072 1.00 130.16 ? -12 DG  C N3    1 
ATOM 2370 C C4    . DG  B 2 21  ? 116.019 98.596  130.961 1.00 130.16 ? -12 DG  C C4    1 
ATOM 2371 P P     . DC  B 2 22  ? 115.164 104.395 128.148 1.00 126.74 ? -11 DC  C P     1 
ATOM 2372 O OP1   . DC  B 2 22  ? 114.174 104.666 129.215 1.00 126.74 ? -11 DC  C OP1   1 
ATOM 2373 O OP2   . DC  B 2 22  ? 115.383 105.413 127.096 1.00 126.74 ? -11 DC  C OP2   1 
ATOM 2374 O "O5'" . DC  B 2 22  ? 116.585 104.042 128.800 1.00 126.74 ? -11 DC  C "O5'" 1 
ATOM 2375 C "C5'" . DC  B 2 22  ? 117.324 105.043 129.504 1.00 126.74 ? -11 DC  C "C5'" 1 
ATOM 2376 C "C4'" . DC  B 2 22  ? 116.720 105.299 130.874 1.00 126.74 ? -11 DC  C "C4'" 1 
ATOM 2377 O "O4'" . DC  B 2 22  ? 116.069 104.094 131.343 1.00 126.74 ? -11 DC  C "O4'" 1 
ATOM 2378 C "C3'" . DC  B 2 22  ? 117.717 105.660 131.963 1.00 126.74 ? -11 DC  C "C3'" 1 
ATOM 2379 O "O3'" . DC  B 2 22  ? 117.949 107.064 131.965 1.00 126.74 ? -11 DC  C "O3'" 1 
ATOM 2380 C "C2'" . DC  B 2 22  ? 116.985 105.210 133.223 1.00 126.74 ? -11 DC  C "C2'" 1 
ATOM 2381 C "C1'" . DC  B 2 22  ? 116.263 103.951 132.739 1.00 126.74 ? -11 DC  C "C1'" 1 
ATOM 2382 N N1    . DC  B 2 22  ? 117.023 102.689 132.988 1.00 126.74 ? -11 DC  C N1    1 
ATOM 2383 C C2    . DC  B 2 22  ? 116.922 102.056 134.231 1.00 126.74 ? -11 DC  C C2    1 
ATOM 2384 O O2    . DC  B 2 22  ? 116.204 102.555 135.106 1.00 126.74 ? -11 DC  C O2    1 
ATOM 2385 N N3    . DC  B 2 22  ? 117.616 100.911 134.442 1.00 126.74 ? -11 DC  C N3    1 
ATOM 2386 C C4    . DC  B 2 22  ? 118.380 100.405 133.474 1.00 126.74 ? -11 DC  C C4    1 
ATOM 2387 N N4    . DC  B 2 22  ? 119.045 99.275  133.730 1.00 126.74 ? -11 DC  C N4    1 
ATOM 2388 C C5    . DC  B 2 22  ? 118.496 101.034 132.200 1.00 126.74 ? -11 DC  C C5    1 
ATOM 2389 C C6    . DC  B 2 22  ? 117.806 102.162 132.002 1.00 126.74 ? -11 DC  C C6    1 
ATOM 2390 P P     . DA  B 2 23  ? 119.052 107.703 132.945 1.00 118.08 ? -10 DA  C P     1 
ATOM 2391 O OP1   . DA  B 2 23  ? 118.360 108.133 134.180 1.00 118.08 ? -10 DA  C OP1   1 
ATOM 2392 O OP2   . DA  B 2 23  ? 119.831 108.686 132.160 1.00 118.08 ? -10 DA  C OP2   1 
ATOM 2393 O "O5'" . DA  B 2 23  ? 120.004 106.473 133.320 1.00 118.08 ? -10 DA  C "O5'" 1 
ATOM 2394 C "C5'" . DA  B 2 23  ? 120.182 106.107 134.685 1.00 118.08 ? -10 DA  C "C5'" 1 
ATOM 2395 C "C4'" . DA  B 2 23  ? 121.489 105.360 134.883 1.00 118.08 ? -10 DA  C "C4'" 1 
ATOM 2396 O "O4'" . DA  B 2 23  ? 121.412 104.061 134.248 1.00 118.08 ? -10 DA  C "O4'" 1 
ATOM 2397 C "C3'" . DA  B 2 23  ? 122.729 106.051 134.299 1.00 118.08 ? -10 DA  C "C3'" 1 
ATOM 2398 O "O3'" . DA  B 2 23  ? 123.700 106.247 135.319 1.00 118.08 ? -10 DA  C "O3'" 1 
ATOM 2399 C "C2'" . DA  B 2 23  ? 123.231 105.076 133.227 1.00 118.08 ? -10 DA  C "C2'" 1 
ATOM 2400 C "C1'" . DA  B 2 23  ? 122.673 103.751 133.720 1.00 118.08 ? -10 DA  C "C1'" 1 
ATOM 2401 N N9    . DA  B 2 23  ? 122.510 102.750 132.668 1.00 118.08 ? -10 DA  C N9    1 
ATOM 2402 C C8    . DA  B 2 23  ? 123.060 101.499 132.633 1.00 118.08 ? -10 DA  C C8    1 
ATOM 2403 N N7    . DA  B 2 23  ? 122.745 100.810 131.563 1.00 118.08 ? -10 DA  C N7    1 
ATOM 2404 C C5    . DA  B 2 23  ? 121.932 101.668 130.843 1.00 118.08 ? -10 DA  C C5    1 
ATOM 2405 C C6    . DA  B 2 23  ? 121.269 101.532 129.608 1.00 118.08 ? -10 DA  C C6    1 
ATOM 2406 N N6    . DA  B 2 23  ? 121.331 100.428 128.857 1.00 118.08 ? -10 DA  C N6    1 
ATOM 2407 N N1    . DA  B 2 23  ? 120.538 102.579 129.173 1.00 118.08 ? -10 DA  C N1    1 
ATOM 2408 C C2    . DA  B 2 23  ? 120.480 103.682 129.928 1.00 118.08 ? -10 DA  C C2    1 
ATOM 2409 N N3    . DA  B 2 23  ? 121.057 103.926 131.103 1.00 118.08 ? -10 DA  C N3    1 
ATOM 2410 C C4    . DA  B 2 23  ? 121.776 102.869 131.509 1.00 118.08 ? -10 DA  C C4    1 
ATOM 2411 P P     . DC  B 2 24  ? 124.509 107.632 135.412 1.00 105.67 ? -9  DC  C P     1 
ATOM 2412 O OP1   . DC  B 2 24  ? 124.374 108.139 136.795 1.00 105.67 ? -9  DC  C OP1   1 
ATOM 2413 O OP2   . DC  B 2 24  ? 124.084 108.476 134.273 1.00 105.67 ? -9  DC  C OP2   1 
ATOM 2414 O "O5'" . DC  B 2 24  ? 126.031 107.207 135.163 1.00 105.67 ? -9  DC  C "O5'" 1 
ATOM 2415 C "C5'" . DC  B 2 24  ? 126.490 106.941 133.843 1.00 105.67 ? -9  DC  C "C5'" 1 
ATOM 2416 C "C4'" . DC  B 2 24  ? 127.368 105.704 133.817 1.00 105.67 ? -9  DC  C "C4'" 1 
ATOM 2417 O "O4'" . DC  B 2 24  ? 126.564 104.557 133.446 1.00 105.67 ? -9  DC  C "O4'" 1 
ATOM 2418 C "C3'" . DC  B 2 24  ? 128.494 105.737 132.797 1.00 105.67 ? -9  DC  C "C3'" 1 
ATOM 2419 O "O3'" . DC  B 2 24  ? 129.646 106.366 133.359 1.00 105.67 ? -9  DC  C "O3'" 1 
ATOM 2420 C "C2'" . DC  B 2 24  ? 128.738 104.253 132.548 1.00 105.67 ? -9  DC  C "C2'" 1 
ATOM 2421 C "C1'" . DC  B 2 24  ? 127.326 103.673 132.641 1.00 105.67 ? -9  DC  C "C1'" 1 
ATOM 2422 N N1    . DC  B 2 24  ? 126.650 103.525 131.316 1.00 105.67 ? -9  DC  C N1    1 
ATOM 2423 C C2    . DC  B 2 24  ? 126.929 102.409 130.518 1.00 105.67 ? -9  DC  C C2    1 
ATOM 2424 O O2    . DC  B 2 24  ? 127.734 101.563 130.925 1.00 105.67 ? -9  DC  C O2    1 
ATOM 2425 N N3    . DC  B 2 24  ? 126.307 102.288 129.319 1.00 105.67 ? -9  DC  C N3    1 
ATOM 2426 C C4    . DC  B 2 24  ? 125.445 103.223 128.916 1.00 105.67 ? -9  DC  C C4    1 
ATOM 2427 N N4    . DC  B 2 24  ? 124.857 103.060 127.726 1.00 105.67 ? -9  DC  C N4    1 
ATOM 2428 C C5    . DC  B 2 24  ? 125.148 104.365 129.714 1.00 105.67 ? -9  DC  C C5    1 
ATOM 2429 C C6    . DC  B 2 24  ? 125.767 104.475 130.894 1.00 105.67 ? -9  DC  C C6    1 
ATOM 2430 P P     . DG  B 2 25  ? 130.122 107.811 132.837 1.00 91.84  ? -8  DG  C P     1 
ATOM 2431 O OP1   . DG  B 2 25  ? 131.303 108.206 133.636 1.00 91.84  ? -8  DG  C OP1   1 
ATOM 2432 O OP2   . DG  B 2 25  ? 128.937 108.696 132.799 1.00 91.84  ? -8  DG  C OP2   1 
ATOM 2433 O "O5'" . DG  B 2 25  ? 130.610 107.546 131.337 1.00 91.84  ? -8  DG  C "O5'" 1 
ATOM 2434 C "C5'" . DG  B 2 25  ? 131.992 107.335 131.059 1.00 91.84  ? -8  DG  C "C5'" 1 
ATOM 2435 C "C4'" . DG  B 2 25  ? 132.434 105.960 131.523 1.00 91.84  ? -8  DG  C "C4'" 1 
ATOM 2436 O "O4'" . DG  B 2 25  ? 131.427 104.993 131.167 1.00 91.84  ? -8  DG  C "O4'" 1 
ATOM 2437 C "C3'" . DG  B 2 25  ? 133.706 105.446 130.877 1.00 91.84  ? -8  DG  C "C3'" 1 
ATOM 2438 O "O3'" . DG  B 2 25  ? 134.838 105.916 131.596 1.00 91.84  ? -8  DG  C "O3'" 1 
ATOM 2439 C "C2'" . DG  B 2 25  ? 133.550 103.932 131.008 1.00 91.84  ? -8  DG  C "C2'" 1 
ATOM 2440 C "C1'" . DG  B 2 25  ? 132.032 103.737 130.917 1.00 91.84  ? -8  DG  C "C1'" 1 
ATOM 2441 N N9    . DG  B 2 25  ? 131.577 103.230 129.618 1.00 91.84  ? -8  DG  C N9    1 
ATOM 2442 C C8    . DG  B 2 25  ? 132.148 102.211 128.893 1.00 91.84  ? -8  DG  C C8    1 
ATOM 2443 N N7    . DG  B 2 25  ? 131.532 101.960 127.772 1.00 91.84  ? -8  DG  C N7    1 
ATOM 2444 C C5    . DG  B 2 25  ? 130.480 102.864 127.749 1.00 91.84  ? -8  DG  C C5    1 
ATOM 2445 C C6    . DG  B 2 25  ? 129.471 103.059 126.777 1.00 91.84  ? -8  DG  C C6    1 
ATOM 2446 O O6    . DG  B 2 25  ? 129.307 102.452 125.711 1.00 91.84  ? -8  DG  C O6    1 
ATOM 2447 N N1    . DG  B 2 25  ? 128.596 104.080 127.138 1.00 91.84  ? -8  DG  C N1    1 
ATOM 2448 C C2    . DG  B 2 25  ? 128.685 104.818 128.293 1.00 91.84  ? -8  DG  C C2    1 
ATOM 2449 N N2    . DG  B 2 25  ? 127.748 105.761 128.468 1.00 91.84  ? -8  DG  C N2    1 
ATOM 2450 N N3    . DG  B 2 25  ? 129.623 104.645 129.213 1.00 91.84  ? -8  DG  C N3    1 
ATOM 2451 C C4    . DG  B 2 25  ? 130.487 103.654 128.878 1.00 91.84  ? -8  DG  C C4    1 
ATOM 2452 P P     . DT  B 2 26  ? 136.125 106.461 130.805 1.00 77.76  ? -7  DT  C P     1 
ATOM 2453 O OP1   . DT  B 2 26  ? 137.270 106.446 131.743 1.00 77.76  ? -7  DT  C OP1   1 
ATOM 2454 O OP2   . DT  B 2 26  ? 135.740 107.721 130.132 1.00 77.76  ? -7  DT  C OP2   1 
ATOM 2455 O "O5'" . DT  B 2 26  ? 136.370 105.357 129.675 1.00 77.76  ? -7  DT  C "O5'" 1 
ATOM 2456 C "C5'" . DT  B 2 26  ? 136.413 105.739 128.307 1.00 77.76  ? -7  DT  C "C5'" 1 
ATOM 2457 C "C4'" . DT  B 2 26  ? 135.733 104.699 127.437 1.00 77.76  ? -7  DT  C "C4'" 1 
ATOM 2458 O "O4'" . DT  B 2 26  ? 134.307 104.782 127.614 1.00 77.76  ? -7  DT  C "O4'" 1 
ATOM 2459 C "C3'" . DT  B 2 26  ? 135.945 104.882 125.949 1.00 77.76  ? -7  DT  C "C3'" 1 
ATOM 2460 O "O3'" . DT  B 2 26  ? 137.148 104.242 125.558 1.00 77.76  ? -7  DT  C "O3'" 1 
ATOM 2461 C "C2'" . DT  B 2 26  ? 134.724 104.186 125.346 1.00 77.76  ? -7  DT  C "C2'" 1 
ATOM 2462 C "C1'" . DT  B 2 26  ? 133.660 104.320 126.445 1.00 77.76  ? -7  DT  C "C1'" 1 
ATOM 2463 N N1    . DT  B 2 26  ? 132.555 105.265 126.107 1.00 77.76  ? -7  DT  C N1    1 
ATOM 2464 C C2    . DT  B 2 26  ? 131.605 104.889 125.187 1.00 77.76  ? -7  DT  C C2    1 
ATOM 2465 O O2    . DT  B 2 26  ? 131.617 103.814 124.616 1.00 77.76  ? -7  DT  C O2    1 
ATOM 2466 N N3    . DT  B 2 26  ? 130.634 105.823 124.955 1.00 77.76  ? -7  DT  C N3    1 
ATOM 2467 C C4    . DT  B 2 26  ? 130.517 107.070 125.539 1.00 77.76  ? -7  DT  C C4    1 
ATOM 2468 O O4    . DT  B 2 26  ? 129.605 107.841 125.262 1.00 77.76  ? -7  DT  C O4    1 
ATOM 2469 C C5    . DT  B 2 26  ? 131.543 107.400 126.497 1.00 77.76  ? -7  DT  C C5    1 
ATOM 2470 C C7    . DT  B 2 26  ? 131.523 108.727 127.196 1.00 77.76  ? -7  DT  C C7    1 
ATOM 2471 C C6    . DT  B 2 26  ? 132.501 106.492 126.732 1.00 77.76  ? -7  DT  C C6    1 
ATOM 2472 P P     . DA  B 2 27  ? 138.291 105.067 124.790 1.00 58.53  ? -6  DA  C P     1 
ATOM 2473 O OP1   . DA  B 2 27  ? 139.495 104.210 124.721 1.00 58.53  ? -6  DA  C OP1   1 
ATOM 2474 O OP2   . DA  B 2 27  ? 138.375 106.409 125.408 1.00 58.53  ? -6  DA  C OP2   1 
ATOM 2475 O "O5'" . DA  B 2 27  ? 137.701 105.247 123.317 1.00 58.53  ? -6  DA  C "O5'" 1 
ATOM 2476 C "C5'" . DA  B 2 27  ? 137.260 104.112 122.587 1.00 58.53  ? -6  DA  C "C5'" 1 
ATOM 2477 C "C4'" . DA  B 2 27  ? 136.498 104.540 121.350 1.00 58.53  ? -6  DA  C "C4'" 1 
ATOM 2478 O "O4'" . DA  B 2 27  ? 135.164 104.946 121.719 1.00 58.53  ? -6  DA  C "O4'" 1 
ATOM 2479 C "C3'" . DA  B 2 27  ? 137.110 105.728 120.606 1.00 58.53  ? -6  DA  C "C3'" 1 
ATOM 2480 O "O3'" . DA  B 2 27  ? 137.573 105.314 119.329 1.00 58.53  ? -6  DA  C "O3'" 1 
ATOM 2481 C "C2'" . DA  B 2 27  ? 135.967 106.753 120.498 1.00 58.53  ? -6  DA  C "C2'" 1 
ATOM 2482 C "C1'" . DA  B 2 27  ? 134.733 105.923 120.816 1.00 58.53  ? -6  DA  C "C1'" 1 
ATOM 2483 N N9    . DA  B 2 27  ? 133.661 106.689 121.440 1.00 58.53  ? -6  DA  C N9    1 
ATOM 2484 C C8    . DA  B 2 27  ? 133.681 107.280 122.670 1.00 58.53  ? -6  DA  C C8    1 
ATOM 2485 N N7    . DA  B 2 27  ? 132.570 107.908 122.974 1.00 58.53  ? -6  DA  C N7    1 
ATOM 2486 C C5    . DA  B 2 27  ? 131.765 107.713 121.865 1.00 58.53  ? -6  DA  C C5    1 
ATOM 2487 C C6    . DA  B 2 27  ? 130.453 108.129 121.559 1.00 58.53  ? -6  DA  C C6    1 
ATOM 2488 N N6    . DA  B 2 27  ? 129.700 108.859 122.387 1.00 58.53  ? -6  DA  C N6    1 
ATOM 2489 N N1    . DA  B 2 27  ? 129.946 107.766 120.365 1.00 58.53  ? -6  DA  C N1    1 
ATOM 2490 C C2    . DA  B 2 27  ? 130.704 107.038 119.538 1.00 58.53  ? -6  DA  C C2    1 
ATOM 2491 N N3    . DA  B 2 27  ? 131.945 106.588 119.715 1.00 58.53  ? -6  DA  C N3    1 
ATOM 2492 C C4    . DA  B 2 27  ? 132.422 106.964 120.911 1.00 58.53  ? -6  DA  C C4    1 
ATOM 2493 P P     . DG  B 2 28  ? 138.591 106.238 118.499 1.00 48.41  ? -5  DG  C P     1 
ATOM 2494 O OP1   . DG  B 2 28  ? 139.274 105.371 117.516 1.00 48.41  ? -5  DG  C OP1   1 
ATOM 2495 O OP2   . DG  B 2 28  ? 139.386 107.026 119.465 1.00 48.41  ? -5  DG  C OP2   1 
ATOM 2496 O "O5'" . DG  B 2 28  ? 137.631 107.250 117.721 1.00 48.41  ? -5  DG  C "O5'" 1 
ATOM 2497 C "C5'" . DG  B 2 28  ? 136.546 106.744 116.969 1.00 48.41  ? -5  DG  C "C5'" 1 
ATOM 2498 C "C4'" . DG  B 2 28  ? 135.588 107.853 116.577 1.00 48.41  ? -5  DG  C "C4'" 1 
ATOM 2499 O "O4'" . DG  B 2 28  ? 134.733 108.196 117.689 1.00 48.41  ? -5  DG  C "O4'" 1 
ATOM 2500 C "C3'" . DG  B 2 28  ? 136.244 109.167 116.134 1.00 48.41  ? -5  DG  C "C3'" 1 
ATOM 2501 O "O3'" . DG  B 2 28  ? 135.922 109.421 114.781 1.00 48.41  ? -5  DG  C "O3'" 1 
ATOM 2502 C "C2'" . DG  B 2 28  ? 135.626 110.226 117.062 1.00 48.41  ? -5  DG  C "C2'" 1 
ATOM 2503 C "C1'" . DG  B 2 28  ? 134.358 109.532 117.524 1.00 48.41  ? -5  DG  C "C1'" 1 
ATOM 2504 N N9    . DG  B 2 28  ? 133.826 110.044 118.782 1.00 48.41  ? -5  DG  C N9    1 
ATOM 2505 C C8    . DG  B 2 28  ? 134.509 110.226 119.958 1.00 48.41  ? -5  DG  C C8    1 
ATOM 2506 N N7    . DG  B 2 28  ? 133.769 110.705 120.919 1.00 48.41  ? -5  DG  C N7    1 
ATOM 2507 C C5    . DG  B 2 28  ? 132.514 110.851 120.342 1.00 48.41  ? -5  DG  C C5    1 
ATOM 2508 C C6    . DG  B 2 28  ? 131.304 111.327 120.900 1.00 48.41  ? -5  DG  C C6    1 
ATOM 2509 O O6    . DG  B 2 28  ? 131.096 111.728 122.054 1.00 48.41  ? -5  DG  C O6    1 
ATOM 2510 N N1    . DG  B 2 28  ? 130.267 111.311 119.972 1.00 48.41  ? -5  DG  C N1    1 
ATOM 2511 C C2    . DG  B 2 28  ? 130.386 110.887 118.671 1.00 48.41  ? -5  DG  C C2    1 
ATOM 2512 N N2    . DG  B 2 28  ? 129.273 110.945 117.924 1.00 48.41  ? -5  DG  C N2    1 
ATOM 2513 N N3    . DG  B 2 28  ? 131.514 110.438 118.136 1.00 48.41  ? -5  DG  C N3    1 
ATOM 2514 C C4    . DG  B 2 28  ? 132.533 110.448 119.027 1.00 48.41  ? -5  DG  C C4    1 
ATOM 2515 P P     . DG  B 2 29  ? 137.025 110.026 113.784 1.00 39.30  ? -4  DG  C P     1 
ATOM 2516 O OP1   . DG  B 2 29  ? 137.511 108.918 112.936 1.00 39.30  ? -4  DG  C OP1   1 
ATOM 2517 O OP2   . DG  B 2 29  ? 137.989 110.804 114.591 1.00 39.30  ? -4  DG  C OP2   1 
ATOM 2518 O "O5'" . DG  B 2 29  ? 136.193 111.057 112.891 1.00 39.30  ? -4  DG  C "O5'" 1 
ATOM 2519 C "C5'" . DG  B 2 29  ? 135.767 112.292 113.449 1.00 39.30  ? -4  DG  C "C5'" 1 
ATOM 2520 C "C4'" . DG  B 2 29  ? 134.370 112.649 112.982 1.00 39.30  ? -4  DG  C "C4'" 1 
ATOM 2521 O "O4'" . DG  B 2 29  ? 133.394 111.962 113.810 1.00 39.30  ? -4  DG  C "O4'" 1 
ATOM 2522 C "C3'" . DG  B 2 29  ? 134.014 114.119 113.111 1.00 39.30  ? -4  DG  C "C3'" 1 
ATOM 2523 O "O3'" . DG  B 2 29  ? 134.412 114.828 111.956 1.00 39.30  ? -4  DG  C "O3'" 1 
ATOM 2524 C "C2'" . DG  B 2 29  ? 132.502 114.058 113.247 1.00 39.30  ? -4  DG  C "C2'" 1 
ATOM 2525 C "C1'" . DG  B 2 29  ? 132.357 112.860 114.170 1.00 39.30  ? -4  DG  C "C1'" 1 
ATOM 2526 N N9    . DG  B 2 29  ? 132.514 113.202 115.580 1.00 39.30  ? -4  DG  C N9    1 
ATOM 2527 C C8    . DG  B 2 29  ? 133.616 112.975 116.366 1.00 39.30  ? -4  DG  C C8    1 
ATOM 2528 N N7    . DG  B 2 29  ? 133.475 113.393 117.591 1.00 39.30  ? -4  DG  C N7    1 
ATOM 2529 C C5    . DG  B 2 29  ? 132.198 113.936 117.620 1.00 39.30  ? -4  DG  C C5    1 
ATOM 2530 C C6    . DG  B 2 29  ? 131.493 114.542 118.683 1.00 39.30  ? -4  DG  C C6    1 
ATOM 2531 O O6    . DG  B 2 29  ? 131.870 114.726 119.849 1.00 39.30  ? -4  DG  C O6    1 
ATOM 2532 N N1    . DG  B 2 29  ? 130.225 114.957 118.288 1.00 39.30  ? -4  DG  C N1    1 
ATOM 2533 C C2    . DG  B 2 29  ? 129.708 114.805 117.028 1.00 39.30  ? -4  DG  C C2    1 
ATOM 2534 N N2    . DG  B 2 29  ? 128.465 115.269 116.837 1.00 39.30  ? -4  DG  C N2    1 
ATOM 2535 N N3    . DG  B 2 29  ? 130.358 114.238 116.022 1.00 39.30  ? -4  DG  C N3    1 
ATOM 2536 C C4    . DG  B 2 29  ? 131.594 113.828 116.390 1.00 39.30  ? -4  DG  C C4    1 
ATOM 2537 P P     . DG  B 2 30  ? 135.068 116.286 112.104 1.00 35.11  ? -3  DG  C P     1 
ATOM 2538 O OP1   . DG  B 2 30  ? 135.432 116.755 110.749 1.00 35.11  ? -3  DG  C OP1   1 
ATOM 2539 O OP2   . DG  B 2 30  ? 136.101 116.208 113.159 1.00 35.11  ? -3  DG  C OP2   1 
ATOM 2540 O "O5'" . DG  B 2 30  ? 133.871 117.190 112.656 1.00 35.11  ? -3  DG  C "O5'" 1 
ATOM 2541 C "C5'" . DG  B 2 30  ? 132.797 117.523 111.804 1.00 35.11  ? -3  DG  C "C5'" 1 
ATOM 2542 C "C4'" . DG  B 2 30  ? 131.707 118.267 112.554 1.00 35.11  ? -3  DG  C "C4'" 1 
ATOM 2543 O "O4'" . DG  B 2 30  ? 131.248 117.477 113.670 1.00 35.11  ? -3  DG  C "O4'" 1 
ATOM 2544 C "C3'" . DG  B 2 30  ? 132.123 119.572 113.193 1.00 35.11  ? -3  DG  C "C3'" 1 
ATOM 2545 O "O3'" . DG  B 2 30  ? 132.159 120.610 112.229 1.00 35.11  ? -3  DG  C "O3'" 1 
ATOM 2546 C "C2'" . DG  B 2 30  ? 130.990 119.778 114.190 1.00 35.11  ? -3  DG  C "C2'" 1 
ATOM 2547 C "C1'" . DG  B 2 30  ? 130.728 118.347 114.664 1.00 35.11  ? -3  DG  C "C1'" 1 
ATOM 2548 N N9    . DG  B 2 30  ? 131.362 118.045 115.942 1.00 35.11  ? -3  DG  C N9    1 
ATOM 2549 C C8    . DG  B 2 30  ? 132.524 117.344 116.148 1.00 35.11  ? -3  DG  C C8    1 
ATOM 2550 N N7    . DG  B 2 30  ? 132.849 117.239 117.406 1.00 35.11  ? -3  DG  C N7    1 
ATOM 2551 C C5    . DG  B 2 30  ? 131.840 117.918 118.076 1.00 35.11  ? -3  DG  C C5    1 
ATOM 2552 C C6    . DG  B 2 30  ? 131.654 118.141 119.459 1.00 35.11  ? -3  DG  C C6    1 
ATOM 2553 O O6    . DG  B 2 30  ? 132.369 117.769 120.399 1.00 35.11  ? -3  DG  C O6    1 
ATOM 2554 N N1    . DG  B 2 30  ? 130.502 118.878 119.711 1.00 35.11  ? -3  DG  C N1    1 
ATOM 2555 C C2    . DG  B 2 30  ? 129.640 119.341 118.750 1.00 35.11  ? -3  DG  C C2    1 
ATOM 2556 N N2    . DG  B 2 30  ? 128.579 120.035 119.187 1.00 35.11  ? -3  DG  C N2    1 
ATOM 2557 N N3    . DG  B 2 30  ? 129.801 119.139 117.451 1.00 35.11  ? -3  DG  C N3    1 
ATOM 2558 C C4    . DG  B 2 30  ? 130.920 118.422 117.189 1.00 35.11  ? -3  DG  C C4    1 
ATOM 2559 P P     . DG  B 2 31  ? 133.072 121.907 112.485 1.00 33.18  ? -2  DG  C P     1 
ATOM 2560 O OP1   . DG  B 2 31  ? 132.927 122.802 111.317 1.00 33.18  ? -2  DG  C OP1   1 
ATOM 2561 O OP2   . DG  B 2 31  ? 134.414 121.433 112.884 1.00 33.18  ? -2  DG  C OP2   1 
ATOM 2562 O "O5'" . DG  B 2 31  ? 132.403 122.608 113.756 1.00 33.18  ? -2  DG  C "O5'" 1 
ATOM 2563 C "C5'" . DG  B 2 31  ? 131.171 123.301 113.620 1.00 33.18  ? -2  DG  C "C5'" 1 
ATOM 2564 C "C4'" . DG  B 2 31  ? 130.675 123.807 114.964 1.00 33.18  ? -2  DG  C "C4'" 1 
ATOM 2565 O "O4'" . DG  B 2 31  ? 130.532 122.698 115.881 1.00 33.18  ? -2  DG  C "O4'" 1 
ATOM 2566 C "C3'" . DG  B 2 31  ? 131.607 124.766 115.682 1.00 33.18  ? -2  DG  C "C3'" 1 
ATOM 2567 O "O3'" . DG  B 2 31  ? 131.427 126.087 115.201 1.00 33.18  ? -2  DG  C "O3'" 1 
ATOM 2568 C "C2'" . DG  B 2 31  ? 131.127 124.629 117.120 1.00 33.18  ? -2  DG  C "C2'" 1 
ATOM 2569 C "C1'" . DG  B 2 31  ? 130.816 123.136 117.202 1.00 33.18  ? -2  DG  C "C1'" 1 
ATOM 2570 N N9    . DG  B 2 31  ? 131.922 122.346 117.734 1.00 33.18  ? -2  DG  C N9    1 
ATOM 2571 C C8    . DG  B 2 31  ? 132.902 121.704 117.019 1.00 33.18  ? -2  DG  C C8    1 
ATOM 2572 N N7    . DG  B 2 31  ? 133.763 121.077 117.769 1.00 33.18  ? -2  DG  C N7    1 
ATOM 2573 C C5    . DG  B 2 31  ? 133.327 121.321 119.064 1.00 33.18  ? -2  DG  C C5    1 
ATOM 2574 C C6    . DG  B 2 31  ? 133.864 120.897 120.302 1.00 33.18  ? -2  DG  C C6    1 
ATOM 2575 O O6    . DG  B 2 31  ? 134.864 120.195 120.505 1.00 33.18  ? -2  DG  C O6    1 
ATOM 2576 N N1    . DG  B 2 31  ? 133.115 121.369 121.376 1.00 33.18  ? -2  DG  C N1    1 
ATOM 2577 C C2    . DG  B 2 31  ? 131.991 122.149 121.266 1.00 33.18  ? -2  DG  C C2    1 
ATOM 2578 N N2    . DG  B 2 31  ? 131.403 122.508 122.415 1.00 33.18  ? -2  DG  C N2    1 
ATOM 2579 N N3    . DG  B 2 31  ? 131.479 122.553 120.114 1.00 33.18  ? -2  DG  C N3    1 
ATOM 2580 C C4    . DG  B 2 31  ? 132.196 122.102 119.058 1.00 33.18  ? -2  DG  C C4    1 
ATOM 2581 P P     . DA  B 2 32  ? 132.593 127.174 115.395 1.00 32.86  ? -1  DA  C P     1 
ATOM 2582 O OP1   . DA  B 2 32  ? 132.240 128.365 114.594 1.00 32.86  ? -1  DA  C OP1   1 
ATOM 2583 O OP2   . DA  B 2 32  ? 133.879 126.481 115.175 1.00 32.86  ? -1  DA  C OP2   1 
ATOM 2584 O "O5'" . DA  B 2 32  ? 132.516 127.557 116.946 1.00 32.86  ? -1  DA  C "O5'" 1 
ATOM 2585 C "C5'" . DA  B 2 32  ? 131.387 128.254 117.453 1.00 32.86  ? -1  DA  C "C5'" 1 
ATOM 2586 C "C4'" . DA  B 2 32  ? 131.448 128.348 118.968 1.00 32.86  ? -1  DA  C "C4'" 1 
ATOM 2587 O "O4'" . DA  B 2 32  ? 131.457 127.016 119.537 1.00 32.86  ? -1  DA  C "O4'" 1 
ATOM 2588 C "C3'" . DA  B 2 32  ? 132.698 129.005 119.520 1.00 32.86  ? -1  DA  C "C3'" 1 
ATOM 2589 O "O3'" . DA  B 2 32  ? 132.543 130.412 119.537 1.00 32.86  ? -1  DA  C "O3'" 1 
ATOM 2590 C "C2'" . DA  B 2 32  ? 132.749 128.431 120.929 1.00 32.86  ? -1  DA  C "C2'" 1 
ATOM 2591 C "C1'" . DA  B 2 32  ? 132.275 126.997 120.696 1.00 32.86  ? -1  DA  C "C1'" 1 
ATOM 2592 N N9    . DA  B 2 32  ? 133.367 126.054 120.482 1.00 32.86  ? -1  DA  C N9    1 
ATOM 2593 C C8    . DA  B 2 32  ? 133.919 125.687 119.288 1.00 32.86  ? -1  DA  C C8    1 
ATOM 2594 N N7    . DA  B 2 32  ? 134.896 124.820 119.401 1.00 32.86  ? -1  DA  C N7    1 
ATOM 2595 C C5    . DA  B 2 32  ? 134.993 124.605 120.764 1.00 32.86  ? -1  DA  C C5    1 
ATOM 2596 C C6    . DA  B 2 32  ? 135.837 123.788 121.537 1.00 32.86  ? -1  DA  C C6    1 
ATOM 2597 N N6    . DA  B 2 32  ? 136.785 123.006 121.013 1.00 32.86  ? -1  DA  C N6    1 
ATOM 2598 N N1    . DA  B 2 32  ? 135.670 123.805 122.874 1.00 32.86  ? -1  DA  C N1    1 
ATOM 2599 C C2    . DA  B 2 32  ? 134.720 124.588 123.395 1.00 32.86  ? -1  DA  C C2    1 
ATOM 2600 N N3    . DA  B 2 32  ? 133.867 125.397 122.771 1.00 32.86  ? -1  DA  C N3    1 
ATOM 2601 C C4    . DA  B 2 32  ? 134.058 125.359 121.445 1.00 32.86  ? -1  DA  C C4    1 
ATOM 2602 P P     . DG  B 2 33  ? 133.837 131.362 119.497 1.00 40.44  ? 0   DG  C P     1 
ATOM 2603 O OP1   . DG  B 2 33  ? 135.034 130.502 119.620 1.00 40.44  ? 0   DG  C OP1   1 
ATOM 2604 O OP2   . DG  B 2 33  ? 133.610 132.452 120.468 1.00 40.44  ? 0   DG  C OP2   1 
ATOM 2605 O "O5'" . DG  B 2 33  ? 133.805 131.998 118.032 1.00 40.44  ? 0   DG  C "O5'" 1 
ATOM 2606 C "C5'" . DG  B 2 33  ? 133.553 133.386 117.868 1.00 40.44  ? 0   DG  C "C5'" 1 
ATOM 2607 C "C4'" . DG  B 2 33  ? 134.850 134.149 117.675 1.00 40.44  ? 0   DG  C "C4'" 1 
ATOM 2608 O "O4'" . DG  B 2 33  ? 135.259 134.061 116.286 1.00 40.44  ? 0   DG  C "O4'" 1 
ATOM 2609 C "C3'" . DG  B 2 33  ? 134.775 135.637 117.992 1.00 40.44  ? 0   DG  C "C3'" 1 
ATOM 2610 O "O3'" . DG  B 2 33  ? 136.015 136.081 118.521 1.00 40.44  ? 0   DG  C "O3'" 1 
ATOM 2611 C "C2'" . DG  B 2 33  ? 134.489 136.260 116.632 1.00 40.44  ? 0   DG  C "C2'" 1 
ATOM 2612 C "C1'" . DG  B 2 33  ? 135.267 135.346 115.696 1.00 40.44  ? 0   DG  C "C1'" 1 
ATOM 2613 N N9    . DG  B 2 33  ? 134.674 135.244 114.367 1.00 40.44  ? 0   DG  C N9    1 
ATOM 2614 C C8    . DG  B 2 33  ? 133.384 134.889 114.065 1.00 40.44  ? 0   DG  C C8    1 
ATOM 2615 N N7    . DG  B 2 33  ? 133.133 134.880 112.788 1.00 40.44  ? 0   DG  C N7    1 
ATOM 2616 C C5    . DG  B 2 33  ? 134.336 135.253 112.204 1.00 40.44  ? 0   DG  C C5    1 
ATOM 2617 C C6    . DG  B 2 33  ? 134.672 135.417 110.842 1.00 40.44  ? 0   DG  C C6    1 
ATOM 2618 O O6    . DG  B 2 33  ? 133.949 135.260 109.850 1.00 40.44  ? 0   DG  C O6    1 
ATOM 2619 N N1    . DG  B 2 33  ? 135.998 135.805 110.682 1.00 40.44  ? 0   DG  C N1    1 
ATOM 2620 C C2    . DG  B 2 33  ? 136.887 136.008 111.710 1.00 40.44  ? 0   DG  C C2    1 
ATOM 2621 N N2    . DG  B 2 33  ? 138.127 136.380 111.360 1.00 40.44  ? 0   DG  C N2    1 
ATOM 2622 N N3    . DG  B 2 33  ? 136.583 135.857 112.992 1.00 40.44  ? 0   DG  C N3    1 
ATOM 2623 C C4    . DG  B 2 33  ? 135.294 135.480 113.162 1.00 40.44  ? 0   DG  C C4    1 
ATOM 2624 P P     . DA  B 2 34  ? 136.130 137.528 119.207 1.00 40.90  ? 1   DA  C P     1 
ATOM 2625 O OP1   . DA  B 2 34  ? 137.265 137.481 120.154 1.00 40.90  ? 1   DA  C OP1   1 
ATOM 2626 O OP2   . DA  B 2 34  ? 134.786 137.917 119.679 1.00 40.90  ? 1   DA  C OP2   1 
ATOM 2627 O "O5'" . DA  B 2 34  ? 136.508 138.495 117.993 1.00 40.90  ? 1   DA  C "O5'" 1 
ATOM 2628 C "C5'" . DA  B 2 34  ? 137.607 138.176 117.151 1.00 40.90  ? 1   DA  C "C5'" 1 
ATOM 2629 C "C4'" . DA  B 2 34  ? 137.727 139.180 116.021 1.00 40.90  ? 1   DA  C "C4'" 1 
ATOM 2630 O "O4'" . DA  B 2 34  ? 136.787 138.848 114.965 1.00 40.90  ? 1   DA  C "O4'" 1 
ATOM 2631 C "C3'" . DA  B 2 34  ? 137.430 140.631 116.413 1.00 40.90  ? 1   DA  C "C3'" 1 
ATOM 2632 O "O3'" . DA  B 2 34  ? 138.389 141.486 115.824 1.00 40.90  ? 1   DA  C "O3'" 1 
ATOM 2633 C "C2'" . DA  B 2 34  ? 136.043 140.870 115.825 1.00 40.90  ? 1   DA  C "C2'" 1 
ATOM 2634 C "C1'" . DA  B 2 34  ? 136.114 140.019 114.573 1.00 40.90  ? 1   DA  C "C1'" 1 
ATOM 2635 N N9    . DA  B 2 34  ? 134.808 139.658 114.033 1.00 40.90  ? 1   DA  C N9    1 
ATOM 2636 C C8    . DA  B 2 34  ? 133.621 139.623 114.706 1.00 40.90  ? 1   DA  C C8    1 
ATOM 2637 N N7    . DA  B 2 34  ? 132.603 139.266 113.961 1.00 40.90  ? 1   DA  C N7    1 
ATOM 2638 C C5    . DA  B 2 34  ? 133.160 139.058 112.712 1.00 40.90  ? 1   DA  C C5    1 
ATOM 2639 C C6    . DA  B 2 34  ? 132.606 138.662 111.479 1.00 40.90  ? 1   DA  C C6    1 
ATOM 2640 N N6    . DA  B 2 34  ? 131.308 138.398 111.307 1.00 40.90  ? 1   DA  C N6    1 
ATOM 2641 N N1    . DA  B 2 34  ? 133.441 138.548 110.428 1.00 40.90  ? 1   DA  C N1    1 
ATOM 2642 C C2    . DA  B 2 34  ? 134.740 138.813 110.605 1.00 40.90  ? 1   DA  C C2    1 
ATOM 2643 N N3    . DA  B 2 34  ? 135.375 139.191 111.712 1.00 40.90  ? 1   DA  C N3    1 
ATOM 2644 C C4    . DA  B 2 34  ? 134.519 139.295 112.739 1.00 40.90  ? 1   DA  C C4    1 
ATOM 2645 P P     . DA  B 2 35  ? 138.782 142.877 116.524 1.00 44.60  ? 2   DA  C P     1 
ATOM 2646 O OP1   . DA  B 2 35  ? 139.693 142.571 117.649 1.00 44.60  ? 2   DA  C OP1   1 
ATOM 2647 O OP2   . DA  B 2 35  ? 137.538 143.640 116.766 1.00 44.60  ? 2   DA  C OP2   1 
ATOM 2648 O "O5'" . DA  B 2 35  ? 139.606 143.637 115.388 1.00 44.60  ? 2   DA  C "O5'" 1 
ATOM 2649 C "C5'" . DA  B 2 35  ? 140.475 142.900 114.540 1.00 44.60  ? 2   DA  C "C5'" 1 
ATOM 2650 C "C4'" . DA  B 2 35  ? 140.226 143.243 113.083 1.00 44.60  ? 2   DA  C "C4'" 1 
ATOM 2651 O "O4'" . DA  B 2 35  ? 138.970 142.672 112.649 1.00 44.60  ? 2   DA  C "O4'" 1 
ATOM 2652 C "C3'" . DA  B 2 35  ? 140.140 144.742 112.778 1.00 44.60  ? 2   DA  C "C3'" 1 
ATOM 2653 O "O3'" . DA  B 2 35  ? 141.178 145.108 111.870 1.00 44.60  ? 2   DA  C "O3'" 1 
ATOM 2654 C "C2'" . DA  B 2 35  ? 138.741 144.926 112.166 1.00 44.60  ? 2   DA  C "C2'" 1 
ATOM 2655 C "C1'" . DA  B 2 35  ? 138.408 143.524 111.689 1.00 44.60  ? 2   DA  C "C1'" 1 
ATOM 2656 N N9    . DA  B 2 35  ? 136.974 143.260 111.602 1.00 44.60  ? 2   DA  C N9    1 
ATOM 2657 C C8    . DA  B 2 35  ? 136.035 143.476 112.570 1.00 44.60  ? 2   DA  C C8    1 
ATOM 2658 N N7    . DA  B 2 35  ? 134.818 143.145 112.211 1.00 44.60  ? 2   DA  C N7    1 
ATOM 2659 C C5    . DA  B 2 35  ? 134.969 142.679 110.917 1.00 44.60  ? 2   DA  C C5    1 
ATOM 2660 C C6    . DA  B 2 35  ? 134.050 142.173 109.975 1.00 44.60  ? 2   DA  C C6    1 
ATOM 2661 N N6    . DA  B 2 35  ? 132.743 142.052 110.216 1.00 44.60  ? 2   DA  C N6    1 
ATOM 2662 N N1    . DA  B 2 35  ? 134.529 141.795 108.775 1.00 44.60  ? 2   DA  C N1    1 
ATOM 2663 C C2    . DA  B 2 35  ? 135.841 141.916 108.537 1.00 44.60  ? 2   DA  C C2    1 
ATOM 2664 N N3    . DA  B 2 35  ? 136.799 142.374 109.340 1.00 44.60  ? 2   DA  C N3    1 
ATOM 2665 C C4    . DA  B 2 35  ? 136.292 142.742 110.526 1.00 44.60  ? 2   DA  C C4    1 
ATOM 2666 P P     . DT  B 2 36  ? 141.165 146.536 111.132 1.00 48.27  ? 3   DT  C P     1 
ATOM 2667 O OP1   . DT  B 2 36  ? 142.560 146.833 110.741 1.00 48.27  ? 3   DT  C OP1   1 
ATOM 2668 O OP2   . DT  B 2 36  ? 140.421 147.506 111.967 1.00 48.27  ? 3   DT  C OP2   1 
ATOM 2669 O "O5'" . DT  B 2 36  ? 140.315 146.263 109.807 1.00 48.27  ? 3   DT  C "O5'" 1 
ATOM 2670 C "C5'" . DT  B 2 36  ? 140.040 147.320 108.909 1.00 48.27  ? 3   DT  C "C5'" 1 
ATOM 2671 C "C4'" . DT  B 2 36  ? 139.296 146.803 107.694 1.00 48.27  ? 3   DT  C "C4'" 1 
ATOM 2672 O "O4'" . DT  B 2 36  ? 138.134 146.046 108.125 1.00 48.27  ? 3   DT  C "O4'" 1 
ATOM 2673 C "C3'" . DT  B 2 36  ? 138.775 147.886 106.754 1.00 48.27  ? 3   DT  C "C3'" 1 
ATOM 2674 O "O3'" . DT  B 2 36  ? 138.928 147.475 105.405 1.00 48.27  ? 3   DT  C "O3'" 1 
ATOM 2675 C "C2'" . DT  B 2 36  ? 137.306 148.007 107.143 1.00 48.27  ? 3   DT  C "C2'" 1 
ATOM 2676 C "C1'" . DT  B 2 36  ? 136.969 146.576 107.534 1.00 48.27  ? 3   DT  C "C1'" 1 
ATOM 2677 N N1    . DT  B 2 36  ? 135.854 146.480 108.518 1.00 48.27  ? 3   DT  C N1    1 
ATOM 2678 C C2    . DT  B 2 36  ? 134.664 145.912 108.134 1.00 48.27  ? 3   DT  C C2    1 
ATOM 2679 O O2    . DT  B 2 36  ? 134.464 145.473 107.018 1.00 48.27  ? 3   DT  C O2    1 
ATOM 2680 N N3    . DT  B 2 36  ? 133.708 145.872 109.111 1.00 48.27  ? 3   DT  C N3    1 
ATOM 2681 C C4    . DT  B 2 36  ? 133.818 146.338 110.406 1.00 48.27  ? 3   DT  C C4    1 
ATOM 2682 O O4    . DT  B 2 36  ? 132.898 146.259 111.212 1.00 48.27  ? 3   DT  C O4    1 
ATOM 2683 C C5    . DT  B 2 36  ? 135.092 146.923 110.745 1.00 48.27  ? 3   DT  C C5    1 
ATOM 2684 C C7    . DT  B 2 36  ? 135.332 147.463 112.123 1.00 48.27  ? 3   DT  C C7    1 
ATOM 2685 C C6    . DT  B 2 36  ? 136.038 146.965 109.795 1.00 48.27  ? 3   DT  C C6    1 
ATOM 2686 P P     . DT  B 2 37  ? 138.788 148.548 104.219 1.00 51.73  ? 4   DT  C P     1 
ATOM 2687 O OP1   . DT  B 2 37  ? 139.721 148.152 103.140 1.00 51.73  ? 4   DT  C OP1   1 
ATOM 2688 O OP2   . DT  B 2 37  ? 138.881 149.894 104.823 1.00 51.73  ? 4   DT  C OP2   1 
ATOM 2689 O "O5'" . DT  B 2 37  ? 137.289 148.353 103.704 1.00 51.73  ? 4   DT  C "O5'" 1 
ATOM 2690 C "C5'" . DT  B 2 37  ? 136.854 147.077 103.261 1.00 51.73  ? 4   DT  C "C5'" 1 
ATOM 2691 C "C4'" . DT  B 2 37  ? 135.365 147.087 102.976 1.00 51.73  ? 4   DT  C "C4'" 1 
ATOM 2692 O "O4'" . DT  B 2 37  ? 134.631 147.044 104.222 1.00 51.73  ? 4   DT  C "O4'" 1 
ATOM 2693 C "C3'" . DT  B 2 37  ? 134.861 148.327 102.226 1.00 51.73  ? 4   DT  C "C3'" 1 
ATOM 2694 O "O3'" . DT  B 2 37  ? 134.217 147.940 101.024 1.00 51.73  ? 4   DT  C "O3'" 1 
ATOM 2695 C "C2'" . DT  B 2 37  ? 133.883 148.986 103.204 1.00 51.73  ? 4   DT  C "C2'" 1 
ATOM 2696 C "C1'" . DT  B 2 37  ? 133.472 147.816 104.079 1.00 51.73  ? 4   DT  C "C1'" 1 
ATOM 2697 N N1    . DT  B 2 37  ? 132.993 148.220 105.430 1.00 51.73  ? 4   DT  C N1    1 
ATOM 2698 C C2    . DT  B 2 37  ? 131.681 147.993 105.770 1.00 51.73  ? 4   DT  C C2    1 
ATOM 2699 O O2    . DT  B 2 37  ? 130.879 147.467 105.019 1.00 51.73  ? 4   DT  C O2    1 
ATOM 2700 N N3    . DT  B 2 37  ? 131.337 148.402 107.028 1.00 51.73  ? 4   DT  C N3    1 
ATOM 2701 C C4    . DT  B 2 37  ? 132.155 149.004 107.963 1.00 51.73  ? 4   DT  C C4    1 
ATOM 2702 O O4    . DT  B 2 37  ? 131.749 149.335 109.071 1.00 51.73  ? 4   DT  C O4    1 
ATOM 2703 C C5    . DT  B 2 37  ? 133.519 149.217 107.544 1.00 51.73  ? 4   DT  C C5    1 
ATOM 2704 C C7    . DT  B 2 37  ? 134.499 149.866 108.475 1.00 51.73  ? 4   DT  C C7    1 
ATOM 2705 C C6    . DT  B 2 37  ? 133.869 148.819 106.311 1.00 51.73  ? 4   DT  C C6    1 
ATOM 2706 P P     . DG  B 2 38  ? 133.963 149.020 99.864  1.00 54.46  ? 5   DG  C P     1 
ATOM 2707 O OP1   . DG  B 2 38  ? 134.226 148.357 98.569  1.00 54.46  ? 5   DG  C OP1   1 
ATOM 2708 O OP2   . DG  B 2 38  ? 134.710 150.246 100.224 1.00 54.46  ? 5   DG  C OP2   1 
ATOM 2709 O "O5'" . DG  B 2 38  ? 132.400 149.341 99.978  1.00 54.46  ? 5   DG  C "O5'" 1 
ATOM 2710 C "C5'" . DG  B 2 38  ? 131.450 148.298 99.802  1.00 54.46  ? 5   DG  C "C5'" 1 
ATOM 2711 C "C4'" . DG  B 2 38  ? 130.076 148.721 100.290 1.00 54.46  ? 5   DG  C "C4'" 1 
ATOM 2712 O "O4'" . DG  B 2 38  ? 130.083 148.844 101.737 1.00 54.46  ? 5   DG  C "O4'" 1 
ATOM 2713 C "C3'" . DG  B 2 38  ? 129.576 150.064 99.752  1.00 54.46  ? 5   DG  C "C3'" 1 
ATOM 2714 O "O3'" . DG  B 2 38  ? 128.218 149.944 99.359  1.00 54.46  ? 5   DG  C "O3'" 1 
ATOM 2715 C "C2'" . DG  B 2 38  ? 129.723 150.996 100.954 1.00 54.46  ? 5   DG  C "C2'" 1 
ATOM 2716 C "C1'" . DG  B 2 38  ? 129.434 150.038 102.094 1.00 54.46  ? 5   DG  C "C1'" 1 
ATOM 2717 N N9    . DG  B 2 38  ? 129.945 150.485 103.386 1.00 54.46  ? 5   DG  C N9    1 
ATOM 2718 C C8    . DG  B 2 38  ? 131.190 150.999 103.652 1.00 54.46  ? 5   DG  C C8    1 
ATOM 2719 N N7    . DG  B 2 38  ? 131.365 151.313 104.905 1.00 54.46  ? 5   DG  C N7    1 
ATOM 2720 C C5    . DG  B 2 38  ? 130.158 150.987 105.509 1.00 54.46  ? 5   DG  C C5    1 
ATOM 2721 C C6    . DG  B 2 38  ? 129.752 151.108 106.858 1.00 54.46  ? 5   DG  C C6    1 
ATOM 2722 O O6    . DG  B 2 38  ? 130.402 151.541 107.820 1.00 54.46  ? 5   DG  C O6    1 
ATOM 2723 N N1    . DG  B 2 38  ? 128.447 150.662 107.045 1.00 54.46  ? 5   DG  C N1    1 
ATOM 2724 C C2    . DG  B 2 38  ? 127.637 150.164 106.054 1.00 54.46  ? 5   DG  C C2    1 
ATOM 2725 N N2    . DG  B 2 38  ? 126.408 149.784 106.426 1.00 54.46  ? 5   DG  C N2    1 
ATOM 2726 N N3    . DG  B 2 38  ? 128.005 150.048 104.786 1.00 54.46  ? 5   DG  C N3    1 
ATOM 2727 C C4    . DG  B 2 38  ? 129.274 150.477 104.587 1.00 54.46  ? 5   DG  C C4    1 
ATOM 2728 P P     . DG  B 2 39  ? 127.705 150.598 97.985  1.00 58.35  ? 6   DG  C P     1 
ATOM 2729 O OP1   . DG  B 2 39  ? 127.680 149.529 96.962  1.00 58.35  ? 6   DG  C OP1   1 
ATOM 2730 O OP2   . DG  B 2 39  ? 128.492 151.827 97.746  1.00 58.35  ? 6   DG  C OP2   1 
ATOM 2731 O "O5'" . DG  B 2 39  ? 126.202 151.033 98.313  1.00 58.35  ? 6   DG  C "O5'" 1 
ATOM 2732 C "C5'" . DG  B 2 39  ? 125.271 150.069 98.789  1.00 58.35  ? 6   DG  C "C5'" 1 
ATOM 2733 C "C4'" . DG  B 2 39  ? 124.149 150.741 99.558  1.00 58.35  ? 6   DG  C "C4'" 1 
ATOM 2734 O "O4'" . DG  B 2 39  ? 124.445 150.703 100.972 1.00 58.35  ? 6   DG  C "O4'" 1 
ATOM 2735 C "C3'" . DG  B 2 39  ? 123.952 152.212 99.241  1.00 58.35  ? 6   DG  C "C3'" 1 
ATOM 2736 O "O3'" . DG  B 2 39  ? 123.100 152.357 98.112  1.00 58.35  ? 6   DG  C "O3'" 1 
ATOM 2737 C "C2'" . DG  B 2 39  ? 123.288 152.731 100.514 1.00 58.35  ? 6   DG  C "C2'" 1 
ATOM 2738 C "C1'" . DG  B 2 39  ? 123.935 151.866 101.602 1.00 58.35  ? 6   DG  C "C1'" 1 
ATOM 2739 N N9    . DG  B 2 39  ? 125.028 152.529 102.311 1.00 58.35  ? 6   DG  C N9    1 
ATOM 2740 C C8    . DG  B 2 39  ? 126.119 153.155 101.757 1.00 58.35  ? 6   DG  C C8    1 
ATOM 2741 N N7    . DG  B 2 39  ? 126.934 153.657 102.643 1.00 58.35  ? 6   DG  C N7    1 
ATOM 2742 C C5    . DG  B 2 39  ? 126.349 153.343 103.861 1.00 58.35  ? 6   DG  C C5    1 
ATOM 2743 C C6    . DG  B 2 39  ? 126.778 153.627 105.178 1.00 58.35  ? 6   DG  C C6    1 
ATOM 2744 O O6    . DG  B 2 39  ? 127.796 154.235 105.540 1.00 58.35  ? 6   DG  C O6    1 
ATOM 2745 N N1    . DG  B 2 39  ? 125.891 153.129 106.128 1.00 58.35  ? 6   DG  C N1    1 
ATOM 2746 C C2    . DG  B 2 39  ? 124.735 152.443 105.840 1.00 58.35  ? 6   DG  C C2    1 
ATOM 2747 N N2    . DG  B 2 39  ? 124.006 152.040 106.891 1.00 58.35  ? 6   DG  C N2    1 
ATOM 2748 N N3    . DG  B 2 39  ? 124.322 152.170 104.611 1.00 58.35  ? 6   DG  C N3    1 
ATOM 2749 C C4    . DG  B 2 39  ? 125.175 152.649 103.675 1.00 58.35  ? 6   DG  C C4    1 
ATOM 2750 P P     . C   C 3 7   ? 139.247 139.845 147.475 1.00 43.82  ? -19 C   B P     1 
ATOM 2751 O OP1   . C   C 3 7   ? 138.498 140.808 148.321 1.00 43.82  ? -19 C   B OP1   1 
ATOM 2752 O OP2   . C   C 3 7   ? 139.952 138.706 148.112 1.00 43.82  ? -19 C   B OP2   1 
ATOM 2753 O "O5'" . C   C 3 7   ? 138.237 139.261 146.392 1.00 43.82  ? -19 C   B "O5'" 1 
ATOM 2754 C "C5'" . C   C 3 7   ? 136.942 138.811 146.772 1.00 43.82  ? -19 C   B "C5'" 1 
ATOM 2755 C "C4'" . C   C 3 7   ? 136.106 138.442 145.572 1.00 43.82  ? -19 C   B "C4'" 1 
ATOM 2756 O "O4'" . C   C 3 7   ? 136.820 137.452 144.788 1.00 43.82  ? -19 C   B "O4'" 1 
ATOM 2757 C "C3'" . C   C 3 7   ? 134.748 137.830 145.896 1.00 43.82  ? -19 C   B "C3'" 1 
ATOM 2758 O "O3'" . C   C 3 7   ? 133.806 138.200 144.891 1.00 43.82  ? -19 C   B "O3'" 1 
ATOM 2759 C "C2'" . C   C 3 7   ? 135.028 136.333 145.817 1.00 43.82  ? -19 C   B "C2'" 1 
ATOM 2760 O "O2'" . C   C 3 7   ? 133.895 135.537 145.540 1.00 43.82  ? -19 C   B "O2'" 1 
ATOM 2761 C "C1'" . C   C 3 7   ? 136.054 136.267 144.690 1.00 43.82  ? -19 C   B "C1'" 1 
ATOM 2762 N N1    . C   C 3 7   ? 136.981 135.132 144.798 1.00 43.82  ? -19 C   B N1    1 
ATOM 2763 C C2    . C   C 3 7   ? 136.818 134.022 143.969 1.00 43.82  ? -19 C   B C2    1 
ATOM 2764 O O2    . C   C 3 7   ? 135.880 134.012 143.160 1.00 43.82  ? -19 C   B O2    1 
ATOM 2765 N N3    . C   C 3 7   ? 137.682 132.987 144.076 1.00 43.82  ? -19 C   B N3    1 
ATOM 2766 C C4    . C   C 3 7   ? 138.678 133.038 144.960 1.00 43.82  ? -19 C   B C4    1 
ATOM 2767 N N4    . C   C 3 7   ? 139.510 131.998 145.036 1.00 43.82  ? -19 C   B N4    1 
ATOM 2768 C C5    . C   C 3 7   ? 138.868 134.160 145.813 1.00 43.82  ? -19 C   B C5    1 
ATOM 2769 C C6    . C   C 3 7   ? 138.006 135.175 145.697 1.00 43.82  ? -19 C   B C6    1 
ATOM 2770 P P     . U   C 3 8   ? 132.766 139.396 145.161 1.00 39.82  ? -18 U   B P     1 
ATOM 2771 O OP1   . U   C 3 8   ? 132.891 140.386 144.065 1.00 39.82  ? -18 U   B OP1   1 
ATOM 2772 O OP2   . U   C 3 8   ? 132.933 139.839 146.566 1.00 39.82  ? -18 U   B OP2   1 
ATOM 2773 O "O5'" . U   C 3 8   ? 131.339 138.705 145.030 1.00 39.82  ? -18 U   B "O5'" 1 
ATOM 2774 C "C5'" . U   C 3 8   ? 130.976 137.610 145.862 1.00 39.82  ? -18 U   B "C5'" 1 
ATOM 2775 C "C4'" . U   C 3 8   ? 129.485 137.390 145.871 1.00 39.82  ? -18 U   B "C4'" 1 
ATOM 2776 O "O4'" . U   C 3 8   ? 128.820 138.662 145.637 1.00 39.82  ? -18 U   B "O4'" 1 
ATOM 2777 C "C3'" . U   C 3 8   ? 128.959 136.437 144.801 1.00 39.82  ? -18 U   B "C3'" 1 
ATOM 2778 O "O3'" . U   C 3 8   ? 127.795 135.779 145.301 1.00 39.82  ? -18 U   B "O3'" 1 
ATOM 2779 C "C2'" . U   C 3 8   ? 128.551 137.391 143.688 1.00 39.82  ? -18 U   B "C2'" 1 
ATOM 2780 O "O2'" . U   C 3 8   ? 127.595 136.868 142.792 1.00 39.82  ? -18 U   B "O2'" 1 
ATOM 2781 C "C1'" . U   C 3 8   ? 127.996 138.562 144.492 1.00 39.82  ? -18 U   B "C1'" 1 
ATOM 2782 N N1    . U   C 3 8   ? 128.024 139.850 143.785 1.00 39.82  ? -18 U   B N1    1 
ATOM 2783 C C2    . U   C 3 8   ? 126.811 140.451 143.519 1.00 39.82  ? -18 U   B C2    1 
ATOM 2784 O O2    . U   C 3 8   ? 125.746 139.957 143.843 1.00 39.82  ? -18 U   B O2    1 
ATOM 2785 N N3    . U   C 3 8   ? 126.890 141.650 142.858 1.00 39.82  ? -18 U   B N3    1 
ATOM 2786 C C4    . U   C 3 8   ? 128.036 142.293 142.446 1.00 39.82  ? -18 U   B C4    1 
ATOM 2787 O O4    . U   C 3 8   ? 127.945 143.372 141.860 1.00 39.82  ? -18 U   B O4    1 
ATOM 2788 C C5    . U   C 3 8   ? 129.250 141.607 142.759 1.00 39.82  ? -18 U   B C5    1 
ATOM 2789 C C6    . U   C 3 8   ? 129.204 140.438 143.403 1.00 39.82  ? -18 U   B C6    1 
ATOM 2790 P P     . U   C 3 9   ? 127.599 134.197 145.104 1.00 36.76  ? -17 U   B P     1 
ATOM 2791 O OP1   . U   C 3 9   ? 126.845 133.689 146.276 1.00 36.76  ? -17 U   B OP1   1 
ATOM 2792 O OP2   . U   C 3 9   ? 128.912 133.602 144.752 1.00 36.76  ? -17 U   B OP2   1 
ATOM 2793 O "O5'" . U   C 3 9   ? 126.643 134.082 143.837 1.00 36.76  ? -17 U   B "O5'" 1 
ATOM 2794 C "C5'" . U   C 3 9   ? 125.315 134.579 143.883 1.00 36.76  ? -17 U   B "C5'" 1 
ATOM 2795 C "C4'" . U   C 3 9   ? 124.573 134.296 142.601 1.00 36.76  ? -17 U   B "C4'" 1 
ATOM 2796 O "O4'" . U   C 3 9   ? 125.373 134.724 141.468 1.00 36.76  ? -17 U   B "O4'" 1 
ATOM 2797 C "C3'" . U   C 3 9   ? 124.280 132.836 142.301 1.00 36.76  ? -17 U   B "C3'" 1 
ATOM 2798 O "O3'" . U   C 3 9   ? 123.171 132.319 143.015 1.00 36.76  ? -17 U   B "O3'" 1 
ATOM 2799 C "C2'" . U   C 3 9   ? 124.087 132.850 140.793 1.00 36.76  ? -17 U   B "C2'" 1 
ATOM 2800 O "O2'" . U   C 3 9   ? 122.815 133.383 140.454 1.00 36.76  ? -17 U   B "O2'" 1 
ATOM 2801 C "C1'" . U   C 3 9   ? 125.156 133.857 140.373 1.00 36.76  ? -17 U   B "C1'" 1 
ATOM 2802 N N1    . U   C 3 9   ? 126.430 133.182 140.039 1.00 36.76  ? -17 U   B N1    1 
ATOM 2803 C C2    . U   C 3 9   ? 126.538 132.615 138.786 1.00 36.76  ? -17 U   B C2    1 
ATOM 2804 O O2    . U   C 3 9   ? 125.649 132.660 137.956 1.00 36.76  ? -17 U   B O2    1 
ATOM 2805 N N3    . U   C 3 9   ? 127.731 131.994 138.533 1.00 36.76  ? -17 U   B N3    1 
ATOM 2806 C C4    . U   C 3 9   ? 128.806 131.880 139.387 1.00 36.76  ? -17 U   B C4    1 
ATOM 2807 O O4    . U   C 3 9   ? 129.816 131.290 139.009 1.00 36.76  ? -17 U   B O4    1 
ATOM 2808 C C5    . U   C 3 9   ? 128.617 132.487 140.665 1.00 36.76  ? -17 U   B C5    1 
ATOM 2809 C C6    . U   C 3 9   ? 127.463 133.099 140.940 1.00 36.76  ? -17 U   B C6    1 
ATOM 2810 P P     . G   C 3 10  ? 123.252 130.854 143.671 1.00 37.74  ? -16 G   B P     1 
ATOM 2811 O OP1   . G   C 3 10  ? 121.895 130.502 144.159 1.00 37.74  ? -16 G   B OP1   1 
ATOM 2812 O OP2   . G   C 3 10  ? 124.404 130.818 144.605 1.00 37.74  ? -16 G   B OP2   1 
ATOM 2813 O "O5'" . G   C 3 10  ? 123.608 129.895 142.450 1.00 37.74  ? -16 G   B "O5'" 1 
ATOM 2814 C "C5'" . G   C 3 10  ? 122.665 129.640 141.420 1.00 37.74  ? -16 G   B "C5'" 1 
ATOM 2815 C "C4'" . G   C 3 10  ? 123.218 128.693 140.385 1.00 37.74  ? -16 G   B "C4'" 1 
ATOM 2816 O "O4'" . G   C 3 10  ? 124.420 129.252 139.792 1.00 37.74  ? -16 G   B "O4'" 1 
ATOM 2817 C "C3'" . G   C 3 10  ? 123.667 127.335 140.895 1.00 37.74  ? -16 G   B "C3'" 1 
ATOM 2818 O "O3'" . G   C 3 10  ? 122.597 126.433 141.107 1.00 37.74  ? -16 G   B "O3'" 1 
ATOM 2819 C "C2'" . G   C 3 10  ? 124.643 126.890 139.817 1.00 37.74  ? -16 G   B "C2'" 1 
ATOM 2820 O "O2'" . G   C 3 10  ? 123.945 126.436 138.666 1.00 37.74  ? -16 G   B "O2'" 1 
ATOM 2821 C "C1'" . G   C 3 10  ? 125.325 128.213 139.476 1.00 37.74  ? -16 G   B "C1'" 1 
ATOM 2822 N N9    . G   C 3 10  ? 126.556 128.403 140.263 1.00 37.74  ? -16 G   B N9    1 
ATOM 2823 C C8    . G   C 3 10  ? 126.757 129.293 141.287 1.00 37.74  ? -16 G   B C8    1 
ATOM 2824 N N7    . G   C 3 10  ? 127.954 129.222 141.797 1.00 37.74  ? -16 G   B N7    1 
ATOM 2825 C C5    . G   C 3 10  ? 128.581 128.223 141.068 1.00 37.74  ? -16 G   B C5    1 
ATOM 2826 C C6    . G   C 3 10  ? 129.894 127.699 141.168 1.00 37.74  ? -16 G   B C6    1 
ATOM 2827 O O6    . G   C 3 10  ? 130.797 128.027 141.946 1.00 37.74  ? -16 G   B O6    1 
ATOM 2828 N N1    . G   C 3 10  ? 130.117 126.694 140.234 1.00 37.74  ? -16 G   B N1    1 
ATOM 2829 C C2    . G   C 3 10  ? 129.196 126.248 139.322 1.00 37.74  ? -16 G   B C2    1 
ATOM 2830 N N2    . G   C 3 10  ? 129.603 125.266 138.505 1.00 37.74  ? -16 G   B N2    1 
ATOM 2831 N N3    . G   C 3 10  ? 127.969 126.727 139.220 1.00 37.74  ? -16 G   B N3    1 
ATOM 2832 C C4    . G   C 3 10  ? 127.731 127.706 140.117 1.00 37.74  ? -16 G   B C4    1 
ATOM 2833 P P     . C   C 3 11  ? 122.599 125.483 142.403 1.00 38.59  ? -15 C   B P     1 
ATOM 2834 O OP1   . C   C 3 11  ? 121.296 124.776 142.459 1.00 38.59  ? -15 C   B OP1   1 
ATOM 2835 O OP2   . C   C 3 11  ? 123.041 126.293 143.565 1.00 38.59  ? -15 C   B OP2   1 
ATOM 2836 O "O5'" . C   C 3 11  ? 123.745 124.422 142.097 1.00 38.59  ? -15 C   B "O5'" 1 
ATOM 2837 C "C5'" . C   C 3 11  ? 123.679 123.583 140.954 1.00 38.59  ? -15 C   B "C5'" 1 
ATOM 2838 C "C4'" . C   C 3 11  ? 124.931 122.756 140.808 1.00 38.59  ? -15 C   B "C4'" 1 
ATOM 2839 O "O4'" . C   C 3 11  ? 126.055 123.621 140.498 1.00 38.59  ? -15 C   B "O4'" 1 
ATOM 2840 C "C3'" . C   C 3 11  ? 125.375 122.007 142.053 1.00 38.59  ? -15 C   B "C3'" 1 
ATOM 2841 O "O3'" . C   C 3 11  ? 124.668 120.796 142.251 1.00 38.59  ? -15 C   B "O3'" 1 
ATOM 2842 C "C2'" . C   C 3 11  ? 126.866 121.820 141.815 1.00 38.59  ? -15 C   B "C2'" 1 
ATOM 2843 O "O2'" . C   C 3 11  ? 127.101 120.755 140.906 1.00 38.59  ? -15 C   B "O2'" 1 
ATOM 2844 C "C1'" . C   C 3 11  ? 127.225 123.135 141.121 1.00 38.59  ? -15 C   B "C1'" 1 
ATOM 2845 N N1    . C   C 3 11  ? 127.705 124.157 142.077 1.00 38.59  ? -15 C   B N1    1 
ATOM 2846 C C2    . C   C 3 11  ? 129.038 124.130 142.490 1.00 38.59  ? -15 C   B C2    1 
ATOM 2847 O O2    . C   C 3 11  ? 129.786 123.248 142.045 1.00 38.59  ? -15 C   B O2    1 
ATOM 2848 N N3    . C   C 3 11  ? 129.479 125.063 143.362 1.00 38.59  ? -15 C   B N3    1 
ATOM 2849 C C4    . C   C 3 11  ? 128.648 125.998 143.820 1.00 38.59  ? -15 C   B C4    1 
ATOM 2850 N N4    . C   C 3 11  ? 129.127 126.898 144.680 1.00 38.59  ? -15 C   B N4    1 
ATOM 2851 C C5    . C   C 3 11  ? 127.284 126.052 143.418 1.00 38.59  ? -15 C   B C5    1 
ATOM 2852 C C6    . C   C 3 11  ? 126.862 125.123 142.553 1.00 38.59  ? -15 C   B C6    1 
ATOM 2853 P P     . U   C 3 12  ? 124.451 120.226 143.736 1.00 42.30  ? -14 U   B P     1 
ATOM 2854 O OP1   . U   C 3 12  ? 123.368 119.212 143.688 1.00 42.30  ? -14 U   B OP1   1 
ATOM 2855 O OP2   . U   C 3 12  ? 124.333 121.382 144.660 1.00 42.30  ? -14 U   B OP2   1 
ATOM 2856 O "O5'" . U   C 3 12  ? 125.818 119.477 144.057 1.00 42.30  ? -14 U   B "O5'" 1 
ATOM 2857 C "C5'" . U   C 3 12  ? 126.289 118.439 143.214 1.00 42.30  ? -14 U   B "C5'" 1 
ATOM 2858 C "C4'" . U   C 3 12  ? 127.663 117.975 143.623 1.00 42.30  ? -14 U   B "C4'" 1 
ATOM 2859 O "O4'" . U   C 3 12  ? 128.629 119.033 143.394 1.00 42.30  ? -14 U   B "O4'" 1 
ATOM 2860 C "C3'" . U   C 3 12  ? 127.841 117.630 145.092 1.00 42.30  ? -14 U   B "C3'" 1 
ATOM 2861 O "O3'" . U   C 3 12  ? 127.354 116.344 145.428 1.00 42.30  ? -14 U   B "O3'" 1 
ATOM 2862 C "C2'" . U   C 3 12  ? 129.342 117.789 145.285 1.00 42.30  ? -14 U   B "C2'" 1 
ATOM 2863 O "O2'" . U   C 3 12  ? 130.037 116.668 144.759 1.00 42.30  ? -14 U   B "O2'" 1 
ATOM 2864 C "C1'" . U   C 3 12  ? 129.629 118.995 144.391 1.00 42.30  ? -14 U   B "C1'" 1 
ATOM 2865 N N1    . U   C 3 12  ? 129.589 120.265 145.150 1.00 42.30  ? -14 U   B N1    1 
ATOM 2866 C C2    . U   C 3 12  ? 130.700 120.596 145.896 1.00 42.30  ? -14 U   B C2    1 
ATOM 2867 O O2    . U   C 3 12  ? 131.694 119.894 145.946 1.00 42.30  ? -14 U   B O2    1 
ATOM 2868 N N3    . U   C 3 12  ? 130.607 121.781 146.580 1.00 42.30  ? -14 U   B N3    1 
ATOM 2869 C C4    . U   C 3 12  ? 129.537 122.651 146.595 1.00 42.30  ? -14 U   B C4    1 
ATOM 2870 O O4    . U   C 3 12  ? 129.606 123.683 147.264 1.00 42.30  ? -14 U   B O4    1 
ATOM 2871 C C5    . U   C 3 12  ? 128.423 122.238 145.801 1.00 42.30  ? -14 U   B C5    1 
ATOM 2872 C C6    . U   C 3 12  ? 128.487 121.089 145.122 1.00 42.30  ? -14 U   B C6    1 
ATOM 2873 P P     . C   C 3 13  ? 126.588 116.117 146.822 1.00 44.83  ? -13 C   B P     1 
ATOM 2874 O OP1   . C   C 3 13  ? 125.794 114.867 146.716 1.00 44.83  ? -13 C   B OP1   1 
ATOM 2875 O OP2   . C   C 3 13  ? 125.915 117.389 147.182 1.00 44.83  ? -13 C   B OP2   1 
ATOM 2876 O "O5'" . C   C 3 13  ? 127.760 115.868 147.870 1.00 44.83  ? -13 C   B "O5'" 1 
ATOM 2877 C "C5'" . C   C 3 13  ? 128.563 114.700 147.799 1.00 44.83  ? -13 C   B "C5'" 1 
ATOM 2878 C "C4'" . C   C 3 13  ? 129.781 114.805 148.683 1.00 44.83  ? -13 C   B "C4'" 1 
ATOM 2879 O "O4'" . C   C 3 13  ? 130.596 115.934 148.268 1.00 44.83  ? -13 C   B "O4'" 1 
ATOM 2880 C "C3'" . C   C 3 13  ? 129.523 115.070 150.157 1.00 44.83  ? -13 C   B "C3'" 1 
ATOM 2881 O "O3'" . C   C 3 13  ? 129.142 113.916 150.885 1.00 44.83  ? -13 C   B "O3'" 1 
ATOM 2882 C "C2'" . C   C 3 13  ? 130.842 115.675 150.613 1.00 44.83  ? -13 C   B "C2'" 1 
ATOM 2883 O "O2'" . C   C 3 13  ? 131.829 114.667 150.768 1.00 44.83  ? -13 C   B "O2'" 1 
ATOM 2884 C "C1'" . C   C 3 13  ? 131.211 116.522 149.397 1.00 44.83  ? -13 C   B "C1'" 1 
ATOM 2885 N N1    . C   C 3 13  ? 130.727 117.915 149.531 1.00 44.83  ? -13 C   B N1    1 
ATOM 2886 C C2    . C   C 3 13  ? 131.433 118.795 150.355 1.00 44.83  ? -13 C   B C2    1 
ATOM 2887 O O2    . C   C 3 13  ? 132.446 118.390 150.945 1.00 44.83  ? -13 C   B O2    1 
ATOM 2888 N N3    . C   C 3 13  ? 130.998 120.068 150.486 1.00 44.83  ? -13 C   B N3    1 
ATOM 2889 C C4    . C   C 3 13  ? 129.907 120.473 149.838 1.00 44.83  ? -13 C   B C4    1 
ATOM 2890 N N4    . C   C 3 13  ? 129.516 121.739 149.999 1.00 44.83  ? -13 C   B N4    1 
ATOM 2891 C C5    . C   C 3 13  ? 129.167 119.598 148.994 1.00 44.83  ? -13 C   B C5    1 
ATOM 2892 C C6    . C   C 3 13  ? 129.609 118.342 148.871 1.00 44.83  ? -13 C   B C6    1 
ATOM 2893 P P     . G   C 3 14  ? 128.275 114.071 152.230 1.00 42.59  ? -12 G   B P     1 
ATOM 2894 O OP1   . G   C 3 14  ? 127.952 112.713 152.734 1.00 42.59  ? -12 G   B OP1   1 
ATOM 2895 O OP2   . G   C 3 14  ? 127.184 115.040 151.961 1.00 42.59  ? -12 G   B OP2   1 
ATOM 2896 O "O5'" . G   C 3 14  ? 129.282 114.752 153.259 1.00 42.59  ? -12 G   B "O5'" 1 
ATOM 2897 C "C5'" . G   C 3 14  ? 128.815 115.317 154.474 1.00 42.59  ? -12 G   B "C5'" 1 
ATOM 2898 C "C4'" . G   C 3 14  ? 129.865 116.189 155.114 1.00 42.59  ? -12 G   B "C4'" 1 
ATOM 2899 O "O4'" . G   C 3 14  ? 130.309 117.197 154.168 1.00 42.59  ? -12 G   B "O4'" 1 
ATOM 2900 C "C3'" . G   C 3 14  ? 129.413 116.995 156.322 1.00 42.59  ? -12 G   B "C3'" 1 
ATOM 2901 O "O3'" . G   C 3 14  ? 129.386 116.244 157.522 1.00 42.59  ? -12 G   B "O3'" 1 
ATOM 2902 C "C2'" . G   C 3 14  ? 130.406 118.147 156.336 1.00 42.59  ? -12 G   B "C2'" 1 
ATOM 2903 O "O2'" . G   C 3 14  ? 131.660 117.722 156.847 1.00 42.59  ? -12 G   B "O2'" 1 
ATOM 2904 C "C1'" . G   C 3 14  ? 130.566 118.411 154.842 1.00 42.59  ? -12 G   B "C1'" 1 
ATOM 2905 N N9    . G   C 3 14  ? 129.602 119.418 154.360 1.00 42.59  ? -12 G   B N9    1 
ATOM 2906 C C8    . G   C 3 14  ? 128.598 119.219 153.449 1.00 42.59  ? -12 G   B C8    1 
ATOM 2907 N N7    . G   C 3 14  ? 127.898 120.295 153.214 1.00 42.59  ? -12 G   B N7    1 
ATOM 2908 C C5    . G   C 3 14  ? 128.476 121.264 154.019 1.00 42.59  ? -12 G   B C5    1 
ATOM 2909 C C6    . G   C 3 14  ? 128.144 122.632 154.190 1.00 42.59  ? -12 G   B C6    1 
ATOM 2910 O O6    . G   C 3 14  ? 127.244 123.281 153.645 1.00 42.59  ? -12 G   B O6    1 
ATOM 2911 N N1    . G   C 3 14  ? 128.988 123.250 155.103 1.00 42.59  ? -12 G   B N1    1 
ATOM 2912 C C2    . G   C 3 14  ? 130.018 122.635 155.768 1.00 42.59  ? -12 G   B C2    1 
ATOM 2913 N N2    . G   C 3 14  ? 130.721 123.402 156.613 1.00 42.59  ? -12 G   B N2    1 
ATOM 2914 N N3    . G   C 3 14  ? 130.337 121.361 155.617 1.00 42.59  ? -12 G   B N3    1 
ATOM 2915 C C4    . G   C 3 14  ? 129.530 120.739 154.733 1.00 42.59  ? -12 G   B C4    1 
ATOM 2916 P P     . G   C 3 15  ? 128.167 116.421 158.553 1.00 43.55  ? -11 G   B P     1 
ATOM 2917 O OP1   . G   C 3 15  ? 128.169 115.257 159.474 1.00 43.55  ? -11 G   B OP1   1 
ATOM 2918 O OP2   . G   C 3 15  ? 126.944 116.738 157.774 1.00 43.55  ? -11 G   B OP2   1 
ATOM 2919 O "O5'" . G   C 3 15  ? 128.556 117.718 159.392 1.00 43.55  ? -11 G   B "O5'" 1 
ATOM 2920 C "C5'" . G   C 3 15  ? 129.696 117.724 160.239 1.00 43.55  ? -11 G   B "C5'" 1 
ATOM 2921 C "C4'" . G   C 3 15  ? 129.948 119.093 160.818 1.00 43.55  ? -11 G   B "C4'" 1 
ATOM 2922 O "O4'" . G   C 3 15  ? 130.283 120.022 159.754 1.00 43.55  ? -11 G   B "O4'" 1 
ATOM 2923 C "C3'" . G   C 3 15  ? 128.770 119.753 161.519 1.00 43.55  ? -11 G   B "C3'" 1 
ATOM 2924 O "O3'" . G   C 3 15  ? 128.563 119.288 162.841 1.00 43.55  ? -11 G   B "O3'" 1 
ATOM 2925 C "C2'" . G   C 3 15  ? 129.129 121.228 161.438 1.00 43.55  ? -11 G   B "C2'" 1 
ATOM 2926 O "O2'" . G   C 3 15  ? 130.132 121.551 162.390 1.00 43.55  ? -11 G   B "O2'" 1 
ATOM 2927 C "C1'" . G   C 3 15  ? 129.751 121.299 160.047 1.00 43.55  ? -11 G   B "C1'" 1 
ATOM 2928 N N9    . G   C 3 15  ? 128.745 121.631 159.021 1.00 43.55  ? -11 G   B N9    1 
ATOM 2929 C C8    . G   C 3 15  ? 128.307 120.824 158.000 1.00 43.55  ? -11 G   B C8    1 
ATOM 2930 N N7    . G   C 3 15  ? 127.407 121.395 157.248 1.00 43.55  ? -11 G   B N7    1 
ATOM 2931 C C5    . G   C 3 15  ? 127.239 122.652 157.808 1.00 43.55  ? -11 G   B C5    1 
ATOM 2932 C C6    . G   C 3 15  ? 126.392 123.720 157.425 1.00 43.55  ? -11 G   B C6    1 
ATOM 2933 O O6    . G   C 3 15  ? 125.592 123.770 156.483 1.00 43.55  ? -11 G   B O6    1 
ATOM 2934 N N1    . G   C 3 15  ? 126.536 124.813 158.267 1.00 43.55  ? -11 G   B N1    1 
ATOM 2935 C C2    . G   C 3 15  ? 127.385 124.875 159.341 1.00 43.55  ? -11 G   B C2    1 
ATOM 2936 N N2    . G   C 3 15  ? 127.380 126.022 160.033 1.00 43.55  ? -11 G   B N2    1 
ATOM 2937 N N3    . G   C 3 15  ? 128.181 123.888 159.709 1.00 43.55  ? -11 G   B N3    1 
ATOM 2938 C C4    . G   C 3 15  ? 128.056 122.813 158.903 1.00 43.55  ? -11 G   B C4    1 
ATOM 2939 P P     . U   C 3 16  ? 127.070 119.154 163.417 1.00 45.66  ? -10 U   B P     1 
ATOM 2940 O OP1   . U   C 3 16  ? 127.160 118.626 164.801 1.00 45.66  ? -10 U   B OP1   1 
ATOM 2941 O OP2   . U   C 3 16  ? 126.254 118.435 162.408 1.00 45.66  ? -10 U   B OP2   1 
ATOM 2942 O "O5'" . U   C 3 16  ? 126.544 120.656 163.497 1.00 45.66  ? -10 U   B "O5'" 1 
ATOM 2943 C "C5'" . U   C 3 16  ? 127.068 121.558 164.459 1.00 45.66  ? -10 U   B "C5'" 1 
ATOM 2944 C "C4'" . U   C 3 16  ? 126.452 122.930 164.337 1.00 45.66  ? -10 U   B "C4'" 1 
ATOM 2945 O "O4'" . U   C 3 16  ? 126.649 123.446 162.996 1.00 45.66  ? -10 U   B "O4'" 1 
ATOM 2946 C "C3'" . U   C 3 16  ? 124.950 123.017 164.544 1.00 45.66  ? -10 U   B "C3'" 1 
ATOM 2947 O "O3'" . U   C 3 16  ? 124.580 123.021 165.911 1.00 45.66  ? -10 U   B "O3'" 1 
ATOM 2948 C "C2'" . U   C 3 16  ? 124.589 124.303 163.814 1.00 45.66  ? -10 U   B "C2'" 1 
ATOM 2949 O "O2'" . U   C 3 16  ? 124.905 125.436 164.608 1.00 45.66  ? -10 U   B "O2'" 1 
ATOM 2950 C "C1'" . U   C 3 16  ? 125.554 124.259 162.629 1.00 45.66  ? -10 U   B "C1'" 1 
ATOM 2951 N N1    . U   C 3 16  ? 124.925 123.693 161.413 1.00 45.66  ? -10 U   B N1    1 
ATOM 2952 C C2    . U   C 3 16  ? 124.058 124.501 160.700 1.00 45.66  ? -10 U   B C2    1 
ATOM 2953 O O2    . U   C 3 16  ? 123.790 125.644 161.028 1.00 45.66  ? -10 U   B O2    1 
ATOM 2954 N N3    . U   C 3 16  ? 123.510 123.921 159.584 1.00 45.66  ? -10 U   B N3    1 
ATOM 2955 C C4    . U   C 3 16  ? 123.738 122.644 159.119 1.00 45.66  ? -10 U   B C4    1 
ATOM 2956 O O4    . U   C 3 16  ? 123.170 122.263 158.095 1.00 45.66  ? -10 U   B O4    1 
ATOM 2957 C C5    . U   C 3 16  ? 124.647 121.873 159.908 1.00 45.66  ? -10 U   B C5    1 
ATOM 2958 C C6    . U   C 3 16  ? 125.198 122.411 161.001 1.00 45.66  ? -10 U   B C6    1 
ATOM 2959 P P     . U   C 3 17  ? 123.053 122.757 166.333 1.00 46.74  ? -9  U   B P     1 
ATOM 2960 O OP1   . U   C 3 17  ? 123.061 122.080 167.654 1.00 46.74  ? -9  U   B OP1   1 
ATOM 2961 O OP2   . U   C 3 17  ? 122.369 122.114 165.184 1.00 46.74  ? -9  U   B OP2   1 
ATOM 2962 O "O5'" . U   C 3 17  ? 122.440 124.217 166.518 1.00 46.74  ? -9  U   B "O5'" 1 
ATOM 2963 C "C5'" . U   C 3 17  ? 121.097 124.392 166.954 1.00 46.74  ? -9  U   B "C5'" 1 
ATOM 2964 C "C4'" . U   C 3 17  ? 120.900 125.680 167.720 1.00 46.74  ? -9  U   B "C4'" 1 
ATOM 2965 O "O4'" . U   C 3 17  ? 121.969 125.846 168.694 1.00 46.74  ? -9  U   B "O4'" 1 
ATOM 2966 C "C3'" . U   C 3 17  ? 120.879 126.966 166.887 1.00 46.74  ? -9  U   B "C3'" 1 
ATOM 2967 O "O3'" . U   C 3 17  ? 119.929 127.866 167.457 1.00 46.74  ? -9  U   B "O3'" 1 
ATOM 2968 C "C2'" . U   C 3 17  ? 122.281 127.527 167.101 1.00 46.74  ? -9  U   B "C2'" 1 
ATOM 2969 O "O2'" . U   C 3 17  ? 122.391 128.922 166.911 1.00 46.74  ? -9  U   B "O2'" 1 
ATOM 2970 C "C1'" . U   C 3 17  ? 122.536 127.132 168.550 1.00 46.74  ? -9  U   B "C1'" 1 
ATOM 2971 N N1    . U   C 3 17  ? 123.951 127.096 168.961 1.00 46.74  ? -9  U   B N1    1 
ATOM 2972 C C2    . U   C 3 17  ? 124.866 126.265 168.335 1.00 46.74  ? -9  U   B C2    1 
ATOM 2973 O O2    . U   C 3 17  ? 124.597 125.513 167.418 1.00 46.74  ? -9  U   B O2    1 
ATOM 2974 N N3    . U   C 3 17  ? 126.145 126.339 168.828 1.00 46.74  ? -9  U   B N3    1 
ATOM 2975 C C4    . U   C 3 17  ? 126.603 127.135 169.855 1.00 46.74  ? -9  U   B C4    1 
ATOM 2976 O O4    . U   C 3 17  ? 127.791 127.085 170.179 1.00 46.74  ? -9  U   B O4    1 
ATOM 2977 C C5    . U   C 3 17  ? 125.604 127.963 170.451 1.00 46.74  ? -9  U   B C5    1 
ATOM 2978 C C6    . U   C 3 17  ? 124.351 127.912 169.993 1.00 46.74  ? -9  U   B C6    1 
ATOM 2979 P P     . C   C 3 18  ? 118.999 128.784 166.522 1.00 45.80  ? -8  C   B P     1 
ATOM 2980 O OP1   . C   C 3 18  ? 119.353 130.202 166.777 1.00 45.80  ? -8  C   B OP1   1 
ATOM 2981 O OP2   . C   C 3 18  ? 117.592 128.338 166.689 1.00 45.80  ? -8  C   B OP2   1 
ATOM 2982 O "O5'" . C   C 3 18  ? 119.455 128.434 165.039 1.00 45.80  ? -8  C   B "O5'" 1 
ATOM 2983 C "C5'" . C   C 3 18  ? 119.776 129.471 164.120 1.00 45.80  ? -8  C   B "C5'" 1 
ATOM 2984 C "C4'" . C   C 3 18  ? 119.289 129.167 162.724 1.00 45.80  ? -8  C   B "C4'" 1 
ATOM 2985 O "O4'" . C   C 3 18  ? 120.025 128.034 162.190 1.00 45.80  ? -8  C   B "O4'" 1 
ATOM 2986 C "C3'" . C   C 3 18  ? 117.808 128.813 162.598 1.00 45.80  ? -8  C   B "C3'" 1 
ATOM 2987 O "O3'" . C   C 3 18  ? 117.304 129.323 161.364 1.00 45.80  ? -8  C   B "O3'" 1 
ATOM 2988 C "C2'" . C   C 3 18  ? 117.833 127.289 162.537 1.00 45.80  ? -8  C   B "C2'" 1 
ATOM 2989 O "O2'" . C   C 3 18  ? 116.714 126.708 161.901 1.00 45.80  ? -8  C   B "O2'" 1 
ATOM 2990 C "C1'" . C   C 3 18  ? 119.120 127.039 161.759 1.00 45.80  ? -8  C   B "C1'" 1 
ATOM 2991 N N1    . C   C 3 18  ? 119.731 125.729 162.010 1.00 45.80  ? -8  C   B N1    1 
ATOM 2992 C C2    . C   C 3 18  ? 120.222 125.009 160.921 1.00 45.80  ? -8  C   B C2    1 
ATOM 2993 O O2    . C   C 3 18  ? 120.126 125.502 159.788 1.00 45.80  ? -8  C   B O2    1 
ATOM 2994 N N3    . C   C 3 18  ? 120.791 123.802 161.128 1.00 45.80  ? -8  C   B N3    1 
ATOM 2995 C C4    . C   C 3 18  ? 120.873 123.311 162.363 1.00 45.80  ? -8  C   B C4    1 
ATOM 2996 N N4    . C   C 3 18  ? 121.440 122.114 162.522 1.00 45.80  ? -8  C   B N4    1 
ATOM 2997 C C5    . C   C 3 18  ? 120.379 124.025 163.491 1.00 45.80  ? -8  C   B C5    1 
ATOM 2998 C C6    . C   C 3 18  ? 119.819 125.221 163.272 1.00 45.80  ? -8  C   B C6    1 
ATOM 2999 P P     . G   C 3 19  ? 117.235 130.907 161.104 1.00 43.92  ? -7  G   B P     1 
ATOM 3000 O OP1   . G   C 3 19  ? 117.194 131.596 162.419 1.00 43.92  ? -7  G   B OP1   1 
ATOM 3001 O OP2   . G   C 3 19  ? 116.159 131.165 160.116 1.00 43.92  ? -7  G   B OP2   1 
ATOM 3002 O "O5'" . G   C 3 19  ? 118.631 131.240 160.411 1.00 43.92  ? -7  G   B "O5'" 1 
ATOM 3003 C "C5'" . G   C 3 19  ? 118.818 132.448 159.691 1.00 43.92  ? -7  G   B "C5'" 1 
ATOM 3004 C "C4'" . G   C 3 19  ? 119.784 133.367 160.394 1.00 43.92  ? -7  G   B "C4'" 1 
ATOM 3005 O "O4'" . G   C 3 19  ? 120.065 132.865 161.726 1.00 43.92  ? -7  G   B "O4'" 1 
ATOM 3006 C "C3'" . G   C 3 19  ? 121.160 133.505 159.767 1.00 43.92  ? -7  G   B "C3'" 1 
ATOM 3007 O "O3'" . G   C 3 19  ? 121.186 134.376 158.648 1.00 43.92  ? -7  G   B "O3'" 1 
ATOM 3008 C "C2'" . G   C 3 19  ? 122.006 133.992 160.936 1.00 43.92  ? -7  G   B "C2'" 1 
ATOM 3009 O "O2'" . G   C 3 19  ? 121.818 135.384 161.146 1.00 43.92  ? -7  G   B "O2'" 1 
ATOM 3010 C "C1'" . G   C 3 19  ? 121.374 133.238 162.108 1.00 43.92  ? -7  G   B "C1'" 1 
ATOM 3011 N N9    . G   C 3 19  ? 122.152 132.042 162.497 1.00 43.92  ? -7  G   B N9    1 
ATOM 3012 C C8    . G   C 3 19  ? 122.919 131.938 163.632 1.00 43.92  ? -7  G   B C8    1 
ATOM 3013 N N7    . G   C 3 19  ? 123.524 130.792 163.752 1.00 43.92  ? -7  G   B N7    1 
ATOM 3014 C C5    . G   C 3 19  ? 123.145 130.090 162.621 1.00 43.92  ? -7  G   B C5    1 
ATOM 3015 C C6    . G   C 3 19  ? 123.493 128.781 162.207 1.00 43.92  ? -7  G   B C6    1 
ATOM 3016 O O6    . G   C 3 19  ? 124.225 127.961 162.773 1.00 43.92  ? -7  G   B O6    1 
ATOM 3017 N N1    . G   C 3 19  ? 122.893 128.451 161.001 1.00 43.92  ? -7  G   B N1    1 
ATOM 3018 C C2    . G   C 3 19  ? 122.064 129.277 160.286 1.00 43.92  ? -7  G   B C2    1 
ATOM 3019 N N2    . G   C 3 19  ? 121.577 128.778 159.142 1.00 43.92  ? -7  G   B N2    1 
ATOM 3020 N N3    . G   C 3 19  ? 121.731 130.499 160.662 1.00 43.92  ? -7  G   B N3    1 
ATOM 3021 C C4    . G   C 3 19  ? 122.304 130.845 161.832 1.00 43.92  ? -7  G   B C4    1 
ATOM 3022 P P     . C   C 3 20  ? 121.787 133.875 157.242 1.00 42.37  ? -6  C   B P     1 
ATOM 3023 O OP1   . C   C 3 20  ? 122.096 135.071 156.422 1.00 42.37  ? -6  C   B OP1   1 
ATOM 3024 O OP2   . C   C 3 20  ? 120.885 132.828 156.701 1.00 42.37  ? -6  C   B OP2   1 
ATOM 3025 O "O5'" . C   C 3 20  ? 123.168 133.181 157.626 1.00 42.37  ? -6  C   B "O5'" 1 
ATOM 3026 C "C5'" . C   C 3 20  ? 124.241 133.938 158.174 1.00 42.37  ? -6  C   B "C5'" 1 
ATOM 3027 C "C4'" . C   C 3 20  ? 125.511 133.132 158.262 1.00 42.37  ? -6  C   B "C4'" 1 
ATOM 3028 O "O4'" . C   C 3 20  ? 125.181 131.737 158.519 1.00 42.37  ? -6  C   B "O4'" 1 
ATOM 3029 C "C3'" . C   C 3 20  ? 126.366 133.135 156.998 1.00 42.37  ? -6  C   B "C3'" 1 
ATOM 3030 O "O3'" . C   C 3 20  ? 127.734 133.018 157.380 1.00 42.37  ? -6  C   B "O3'" 1 
ATOM 3031 C "C2'" . C   C 3 20  ? 125.920 131.854 156.307 1.00 42.37  ? -6  C   B "C2'" 1 
ATOM 3032 O "O2'" . C   C 3 20  ? 126.832 131.339 155.362 1.00 42.37  ? -6  C   B "O2'" 1 
ATOM 3033 C "C1'" . C   C 3 20  ? 125.739 130.927 157.502 1.00 42.37  ? -6  C   B "C1'" 1 
ATOM 3034 N N1    . C   C 3 20  ? 124.845 129.790 157.246 1.00 42.37  ? -6  C   B N1    1 
ATOM 3035 C C2    . C   C 3 20  ? 125.220 128.535 157.721 1.00 42.37  ? -6  C   B C2    1 
ATOM 3036 O O2    . C   C 3 20  ? 126.273 128.429 158.364 1.00 42.37  ? -6  C   B O2    1 
ATOM 3037 N N3    . C   C 3 20  ? 124.419 127.473 157.483 1.00 42.37  ? -6  C   B N3    1 
ATOM 3038 C C4    . C   C 3 20  ? 123.292 127.631 156.789 1.00 42.37  ? -6  C   B C4    1 
ATOM 3039 N N4    . C   C 3 20  ? 122.532 126.554 156.579 1.00 42.37  ? -6  C   B N4    1 
ATOM 3040 C C5    . C   C 3 20  ? 122.891 128.901 156.280 1.00 42.37  ? -6  C   B C5    1 
ATOM 3041 C C6    . C   C 3 20  ? 123.693 129.944 156.526 1.00 42.37  ? -6  C   B C6    1 
ATOM 3042 P P     . C   C 3 21  ? 128.917 133.331 156.339 1.00 42.12  ? -5  C   B P     1 
ATOM 3043 O OP1   . C   C 3 21  ? 129.504 134.646 156.703 1.00 42.12  ? -5  C   B OP1   1 
ATOM 3044 O OP2   . C   C 3 21  ? 128.422 133.112 154.956 1.00 42.12  ? -5  C   B OP2   1 
ATOM 3045 O "O5'" . C   C 3 21  ? 129.997 132.208 156.668 1.00 42.12  ? -5  C   B "O5'" 1 
ATOM 3046 C "C5'" . C   C 3 21  ? 130.676 132.215 157.914 1.00 42.12  ? -5  C   B "C5'" 1 
ATOM 3047 C "C4'" . C   C 3 21  ? 131.038 130.826 158.378 1.00 42.12  ? -5  C   B "C4'" 1 
ATOM 3048 O "O4'" . C   C 3 21  ? 129.848 130.010 158.521 1.00 42.12  ? -5  C   B "O4'" 1 
ATOM 3049 C "C3'" . C   C 3 21  ? 131.922 130.013 157.454 1.00 42.12  ? -5  C   B "C3'" 1 
ATOM 3050 O "O3'" . C   C 3 21  ? 133.284 130.386 157.521 1.00 42.12  ? -5  C   B "O3'" 1 
ATOM 3051 C "C2'" . C   C 3 21  ? 131.657 128.589 157.922 1.00 42.12  ? -5  C   B "C2'" 1 
ATOM 3052 O "O2'" . C   C 3 21  ? 132.373 128.313 159.116 1.00 42.12  ? -5  C   B "O2'" 1 
ATOM 3053 C "C1'" . C   C 3 21  ? 130.167 128.657 158.261 1.00 42.12  ? -5  C   B "C1'" 1 
ATOM 3054 N N1    . C   C 3 21  ? 129.320 128.163 157.153 1.00 42.12  ? -5  C   B N1    1 
ATOM 3055 C C2    . C   C 3 21  ? 129.185 126.784 156.975 1.00 42.12  ? -5  C   B C2    1 
ATOM 3056 O O2    . C   C 3 21  ? 129.777 126.015 157.748 1.00 42.12  ? -5  C   B O2    1 
ATOM 3057 N N3    . C   C 3 21  ? 128.414 126.316 155.967 1.00 42.12  ? -5  C   B N3    1 
ATOM 3058 C C4    . C   C 3 21  ? 127.790 127.166 155.155 1.00 42.12  ? -5  C   B C4    1 
ATOM 3059 N N4    . C   C 3 21  ? 127.040 126.665 154.172 1.00 42.12  ? -5  C   B N4    1 
ATOM 3060 C C5    . C   C 3 21  ? 127.910 128.572 155.312 1.00 42.12  ? -5  C   B C5    1 
ATOM 3061 C C6    . C   C 3 21  ? 128.675 129.024 156.313 1.00 42.12  ? -5  C   B C6    1 
ATOM 3062 P P     . G   C 3 22  ? 134.200 130.297 156.208 1.00 40.43  ? -4  G   B P     1 
ATOM 3063 O OP1   . G   C 3 22  ? 135.384 131.167 156.413 1.00 40.43  ? -4  G   B OP1   1 
ATOM 3064 O OP2   . G   C 3 22  ? 133.319 130.519 155.034 1.00 40.43  ? -4  G   B OP2   1 
ATOM 3065 O "O5'" . G   C 3 22  ? 134.686 128.780 156.180 1.00 40.43  ? -4  G   B "O5'" 1 
ATOM 3066 C "C5'" . G   C 3 22  ? 135.415 128.231 157.267 1.00 40.43  ? -4  G   B "C5'" 1 
ATOM 3067 C "C4'" . G   C 3 22  ? 135.581 126.739 157.132 1.00 40.43  ? -4  G   B "C4'" 1 
ATOM 3068 O "O4'" . G   C 3 22  ? 134.282 126.095 157.133 1.00 40.43  ? -4  G   B "O4'" 1 
ATOM 3069 C "C3'" . G   C 3 22  ? 136.231 126.245 155.850 1.00 40.43  ? -4  G   B "C3'" 1 
ATOM 3070 O "O3'" . G   C 3 22  ? 137.643 126.356 155.864 1.00 40.43  ? -4  G   B "O3'" 1 
ATOM 3071 C "C2'" . G   C 3 22  ? 135.738 124.807 155.767 1.00 40.43  ? -4  G   B "C2'" 1 
ATOM 3072 O "O2'" . G   C 3 22  ? 136.484 123.970 156.637 1.00 40.43  ? -4  G   B "O2'" 1 
ATOM 3073 C "C1'" . G   C 3 22  ? 134.321 124.940 156.323 1.00 40.43  ? -4  G   B "C1'" 1 
ATOM 3074 N N9    . G   C 3 22  ? 133.314 125.065 155.254 1.00 40.43  ? -4  G   B N9    1 
ATOM 3075 C C8    . G   C 3 22  ? 132.539 126.154 154.947 1.00 40.43  ? -4  G   B C8    1 
ATOM 3076 N N7    . G   C 3 22  ? 131.739 125.942 153.937 1.00 40.43  ? -4  G   B N7    1 
ATOM 3077 C C5    . G   C 3 22  ? 132.001 124.635 153.557 1.00 40.43  ? -4  G   B C5    1 
ATOM 3078 C C6    . G   C 3 22  ? 131.441 123.845 152.520 1.00 40.43  ? -4  G   B C6    1 
ATOM 3079 O O6    . G   C 3 22  ? 130.570 124.155 151.700 1.00 40.43  ? -4  G   B O6    1 
ATOM 3080 N N1    . G   C 3 22  ? 131.999 122.573 152.488 1.00 40.43  ? -4  G   B N1    1 
ATOM 3081 C C2    . G   C 3 22  ? 132.969 122.114 153.343 1.00 40.43  ? -4  G   B C2    1 
ATOM 3082 N N2    . G   C 3 22  ? 133.380 120.854 153.156 1.00 40.43  ? -4  G   B N2    1 
ATOM 3083 N N3    . G   C 3 22  ? 133.497 122.838 154.312 1.00 40.43  ? -4  G   B N3    1 
ATOM 3084 C C4    . G   C 3 22  ? 132.970 124.080 154.361 1.00 40.43  ? -4  G   B C4    1 
ATOM 3085 P P     . A   C 3 23  ? 138.449 126.581 154.493 1.00 39.13  ? -3  A   B P     1 
ATOM 3086 O OP1   . A   C 3 23  ? 139.885 126.757 154.826 1.00 39.13  ? -3  A   B OP1   1 
ATOM 3087 O OP2   . A   C 3 23  ? 137.744 127.626 153.718 1.00 39.13  ? -3  A   B OP2   1 
ATOM 3088 O "O5'" . A   C 3 23  ? 138.291 125.201 153.712 1.00 39.13  ? -3  A   B "O5'" 1 
ATOM 3089 C "C5'" . A   C 3 23  ? 138.950 124.030 154.167 1.00 39.13  ? -3  A   B "C5'" 1 
ATOM 3090 C "C4'" . A   C 3 23  ? 138.536 122.814 153.378 1.00 39.13  ? -3  A   B "C4'" 1 
ATOM 3091 O "O4'" . A   C 3 23  ? 137.096 122.648 153.446 1.00 39.13  ? -3  A   B "O4'" 1 
ATOM 3092 C "C3'" . A   C 3 23  ? 138.828 122.845 151.887 1.00 39.13  ? -3  A   B "C3'" 1 
ATOM 3093 O "O3'" . A   C 3 23  ? 140.175 122.534 151.578 1.00 39.13  ? -3  A   B "O3'" 1 
ATOM 3094 C "C2'" . A   C 3 23  ? 137.825 121.840 151.337 1.00 39.13  ? -3  A   B "C2'" 1 
ATOM 3095 O "O2'" . A   C 3 23  ? 138.270 120.512 151.566 1.00 39.13  ? -3  A   B "O2'" 1 
ATOM 3096 C "C1'" . A   C 3 23  ? 136.618 122.103 152.234 1.00 39.13  ? -3  A   B "C1'" 1 
ATOM 3097 N N9    . A   C 3 23  ? 135.673 123.058 151.628 1.00 39.13  ? -3  A   B N9    1 
ATOM 3098 C C8    . A   C 3 23  ? 135.528 124.392 151.911 1.00 39.13  ? -3  A   B C8    1 
ATOM 3099 N N7    . A   C 3 23  ? 134.594 124.982 151.208 1.00 39.13  ? -3  A   B N7    1 
ATOM 3100 C C5    . A   C 3 23  ? 134.089 123.967 150.410 1.00 39.13  ? -3  A   B C5    1 
ATOM 3101 C C6    . A   C 3 23  ? 133.074 123.945 149.439 1.00 39.13  ? -3  A   B C6    1 
ATOM 3102 N N6    . A   C 3 23  ? 132.357 125.015 149.092 1.00 39.13  ? -3  A   B N6    1 
ATOM 3103 N N1    . A   C 3 23  ? 132.817 122.771 148.826 1.00 39.13  ? -3  A   B N1    1 
ATOM 3104 C C2    . A   C 3 23  ? 133.537 121.699 149.172 1.00 39.13  ? -3  A   B C2    1 
ATOM 3105 N N3    . A   C 3 23  ? 134.514 121.594 150.068 1.00 39.13  ? -3  A   B N3    1 
ATOM 3106 C C4    . A   C 3 23  ? 134.745 122.778 150.657 1.00 39.13  ? -3  A   B C4    1 
ATOM 3107 P P     . G   C 3 24  ? 140.839 123.076 150.218 1.00 37.53  ? -2  G   B P     1 
ATOM 3108 O OP1   . G   C 3 24  ? 141.632 121.972 149.623 1.00 37.53  ? -2  G   B OP1   1 
ATOM 3109 O OP2   . G   C 3 24  ? 141.488 124.380 150.502 1.00 37.53  ? -2  G   B OP2   1 
ATOM 3110 O "O5'" . G   C 3 24  ? 139.593 123.353 149.267 1.00 37.53  ? -2  G   B "O5'" 1 
ATOM 3111 C "C5'" . G   C 3 24  ? 139.707 123.232 147.859 1.00 37.53  ? -2  G   B "C5'" 1 
ATOM 3112 C "C4'" . G   C 3 24  ? 138.810 122.143 147.327 1.00 37.53  ? -2  G   B "C4'" 1 
ATOM 3113 O "O4'" . G   C 3 24  ? 137.482 122.277 147.896 1.00 37.53  ? -2  G   B "O4'" 1 
ATOM 3114 C "C3'" . G   C 3 24  ? 138.573 122.154 145.826 1.00 37.53  ? -2  G   B "C3'" 1 
ATOM 3115 O "O3'" . G   C 3 24  ? 139.629 121.550 145.101 1.00 37.53  ? -2  G   B "O3'" 1 
ATOM 3116 C "C2'" . G   C 3 24  ? 137.243 121.426 145.692 1.00 37.53  ? -2  G   B "C2'" 1 
ATOM 3117 O "O2'" . G   C 3 24  ? 137.428 120.022 145.789 1.00 37.53  ? -2  G   B "O2'" 1 
ATOM 3118 C "C1'" . G   C 3 24  ? 136.510 121.902 146.945 1.00 37.53  ? -2  G   B "C1'" 1 
ATOM 3119 N N9    . G   C 3 24  ? 135.643 123.066 146.682 1.00 37.53  ? -2  G   B N9    1 
ATOM 3120 C C8    . G   C 3 24  ? 135.764 124.308 147.250 1.00 37.53  ? -2  G   B C8    1 
ATOM 3121 N N7    . G   C 3 24  ? 134.854 125.147 146.843 1.00 37.53  ? -2  G   B N7    1 
ATOM 3122 C C5    . G   C 3 24  ? 134.083 124.414 145.955 1.00 37.53  ? -2  G   B C5    1 
ATOM 3123 C C6    . G   C 3 24  ? 132.949 124.798 145.198 1.00 37.53  ? -2  G   B C6    1 
ATOM 3124 O O6    . G   C 3 24  ? 132.383 125.896 145.163 1.00 37.53  ? -2  G   B O6    1 
ATOM 3125 N N1    . G   C 3 24  ? 132.469 123.749 144.425 1.00 37.53  ? -2  G   B N1    1 
ATOM 3126 C C2    . G   C 3 24  ? 133.013 122.492 144.385 1.00 37.53  ? -2  G   B C2    1 
ATOM 3127 N N2    . G   C 3 24  ? 132.406 121.616 143.571 1.00 37.53  ? -2  G   B N2    1 
ATOM 3128 N N3    . G   C 3 24  ? 134.072 122.120 145.086 1.00 37.53  ? -2  G   B N3    1 
ATOM 3129 C C4    . G   C 3 24  ? 134.553 123.125 145.846 1.00 37.53  ? -2  G   B C4    1 
ATOM 3130 P P     . A   C 3 25  ? 140.085 122.156 143.687 1.00 36.11  ? -1  A   B P     1 
ATOM 3131 O OP1   . A   C 3 25  ? 141.316 121.446 143.258 1.00 36.11  ? -1  A   B OP1   1 
ATOM 3132 O OP2   . A   C 3 25  ? 140.093 123.636 143.798 1.00 36.11  ? -1  A   B OP2   1 
ATOM 3133 O "O5'" . A   C 3 25  ? 138.909 121.741 142.699 1.00 36.11  ? -1  A   B "O5'" 1 
ATOM 3134 C "C5'" . A   C 3 25  ? 138.603 120.375 142.469 1.00 36.11  ? -1  A   B "C5'" 1 
ATOM 3135 C "C4'" . A   C 3 25  ? 137.469 120.223 141.489 1.00 36.11  ? -1  A   B "C4'" 1 
ATOM 3136 O "O4'" . A   C 3 25  ? 136.224 120.636 142.107 1.00 36.11  ? -1  A   B "O4'" 1 
ATOM 3137 C "C3'" . A   C 3 25  ? 137.555 121.076 140.236 1.00 36.11  ? -1  A   B "C3'" 1 
ATOM 3138 O "O3'" . A   C 3 25  ? 138.421 120.534 139.257 1.00 36.11  ? -1  A   B "O3'" 1 
ATOM 3139 C "C2'" . A   C 3 25  ? 136.101 121.157 139.793 1.00 36.11  ? -1  A   B "C2'" 1 
ATOM 3140 O "O2'" . A   C 3 25  ? 135.709 119.959 139.139 1.00 36.11  ? -1  A   B "O2'" 1 
ATOM 3141 C "C1'" . A   C 3 25  ? 135.382 121.228 141.140 1.00 36.11  ? -1  A   B "C1'" 1 
ATOM 3142 N N9    . A   C 3 25  ? 135.105 122.617 141.545 1.00 36.11  ? -1  A   B N9    1 
ATOM 3143 C C8    . A   C 3 25  ? 135.823 123.404 142.408 1.00 36.11  ? -1  A   B C8    1 
ATOM 3144 N N7    . A   C 3 25  ? 135.322 124.604 142.566 1.00 36.11  ? -1  A   B N7    1 
ATOM 3145 C C5    . A   C 3 25  ? 134.200 124.606 141.752 1.00 36.11  ? -1  A   B C5    1 
ATOM 3146 C C6    . A   C 3 25  ? 133.232 125.586 141.476 1.00 36.11  ? -1  A   B C6    1 
ATOM 3147 N N6    . A   C 3 25  ? 133.241 126.808 142.014 1.00 36.11  ? -1  A   B N6    1 
ATOM 3148 N N1    . A   C 3 25  ? 132.241 125.267 140.618 1.00 36.11  ? -1  A   B N1    1 
ATOM 3149 C C2    . A   C 3 25  ? 132.233 124.043 140.080 1.00 36.11  ? -1  A   B C2    1 
ATOM 3150 N N3    . A   C 3 25  ? 133.085 123.038 140.261 1.00 36.11  ? -1  A   B N3    1 
ATOM 3151 C C4    . A   C 3 25  ? 134.056 123.389 141.118 1.00 36.11  ? -1  A   B C4    1 
ATOM 3152 P P     . C   C 3 26  ? 139.563 121.450 138.598 1.00 35.85  ? 0   C   B P     1 
ATOM 3153 O OP1   . C   C 3 26  ? 140.503 120.559 137.876 1.00 35.85  ? 0   C   B OP1   1 
ATOM 3154 O OP2   . C   C 3 26  ? 140.078 122.370 139.643 1.00 35.85  ? 0   C   B OP2   1 
ATOM 3155 O "O5'" . C   C 3 26  ? 138.780 122.321 137.522 1.00 35.85  ? 0   C   B "O5'" 1 
ATOM 3156 C "C5'" . C   C 3 26  ? 138.107 121.701 136.438 1.00 35.85  ? 0   C   B "C5'" 1 
ATOM 3157 C "C4'" . C   C 3 26  ? 136.993 122.567 135.910 1.00 35.85  ? 0   C   B "C4'" 1 
ATOM 3158 O "O4'" . C   C 3 26  ? 136.082 122.904 136.986 1.00 35.85  ? 0   C   B "O4'" 1 
ATOM 3159 C "C3'" . C   C 3 26  ? 137.404 123.913 135.337 1.00 35.85  ? 0   C   B "C3'" 1 
ATOM 3160 O "O3'" . C   C 3 26  ? 137.864 123.815 134.000 1.00 35.85  ? 0   C   B "O3'" 1 
ATOM 3161 C "C2'" . C   C 3 26  ? 136.132 124.740 135.478 1.00 35.85  ? 0   C   B "C2'" 1 
ATOM 3162 O "O2'" . C   C 3 26  ? 135.222 124.443 134.429 1.00 35.85  ? 0   C   B "O2'" 1 
ATOM 3163 C "C1'" . C   C 3 26  ? 135.554 124.197 136.785 1.00 35.85  ? 0   C   B "C1'" 1 
ATOM 3164 N N1    . C   C 3 26  ? 135.904 125.038 137.952 1.00 35.85  ? 0   C   B N1    1 
ATOM 3165 C C2    . C   C 3 26  ? 135.122 126.159 138.231 1.00 35.85  ? 0   C   B C2    1 
ATOM 3166 O O2    . C   C 3 26  ? 134.163 126.421 137.491 1.00 35.85  ? 0   C   B O2    1 
ATOM 3167 N N3    . C   C 3 26  ? 135.430 126.932 139.296 1.00 35.85  ? 0   C   B N3    1 
ATOM 3168 C C4    . C   C 3 26  ? 136.469 126.619 140.069 1.00 35.85  ? 0   C   B C4    1 
ATOM 3169 N N4    . C   C 3 26  ? 136.734 127.411 141.109 1.00 35.85  ? 0   C   B N4    1 
ATOM 3170 C C5    . C   C 3 26  ? 137.282 125.480 139.812 1.00 35.85  ? 0   C   B C5    1 
ATOM 3171 C C6    . C   C 3 26  ? 136.965 124.724 138.754 1.00 35.85  ? 0   C   B C6    1 
ATOM 3172 P P     . U   C 3 27  ? 139.339 124.310 133.601 1.00 37.62  ? 1   U   B P     1 
ATOM 3173 O OP1   . U   C 3 27  ? 140.301 123.229 133.929 1.00 37.62  ? 1   U   B OP1   1 
ATOM 3174 O OP2   . U   C 3 27  ? 139.539 125.669 134.165 1.00 37.62  ? 1   U   B OP2   1 
ATOM 3175 O "O5'" . U   C 3 27  ? 139.282 124.433 132.014 1.00 37.62  ? 1   U   B "O5'" 1 
ATOM 3176 C "C5'" . U   C 3 27  ? 138.973 123.302 131.205 1.00 37.62  ? 1   U   B "C5'" 1 
ATOM 3177 C "C4'" . U   C 3 27  ? 137.508 123.258 130.846 1.00 37.62  ? 1   U   B "C4'" 1 
ATOM 3178 O "O4'" . U   C 3 27  ? 137.351 123.507 129.420 1.00 37.62  ? 1   U   B "O4'" 1 
ATOM 3179 C "C3'" . U   C 3 27  ? 136.807 121.929 131.124 1.00 37.62  ? 1   U   B "C3'" 1 
ATOM 3180 O "O3'" . U   C 3 27  ? 135.454 122.184 131.494 1.00 37.62  ? 1   U   B "O3'" 1 
ATOM 3181 C "C2'" . U   C 3 27  ? 136.836 121.252 129.759 1.00 37.62  ? 1   U   B "C2'" 1 
ATOM 3182 O "O2'" . U   C 3 27  ? 135.852 120.257 129.574 1.00 37.62  ? 1   U   B "O2'" 1 
ATOM 3183 C "C1'" . U   C 3 27  ? 136.624 122.445 128.835 1.00 37.62  ? 1   U   B "C1'" 1 
ATOM 3184 N N1    . U   C 3 27  ? 137.105 122.242 127.460 1.00 37.62  ? 1   U   B N1    1 
ATOM 3185 C C2    . U   C 3 27  ? 136.301 122.712 126.444 1.00 37.62  ? 1   U   B C2    1 
ATOM 3186 O O2    . U   C 3 27  ? 135.247 123.285 126.653 1.00 37.62  ? 1   U   B O2    1 
ATOM 3187 N N3    . U   C 3 27  ? 136.780 122.501 125.176 1.00 37.62  ? 1   U   B N3    1 
ATOM 3188 C C4    . U   C 3 27  ? 137.956 121.872 124.831 1.00 37.62  ? 1   U   B C4    1 
ATOM 3189 O O4    . U   C 3 27  ? 138.252 121.756 123.641 1.00 37.62  ? 1   U   B O4    1 
ATOM 3190 C C5    . U   C 3 27  ? 138.731 121.406 125.941 1.00 37.62  ? 1   U   B C5    1 
ATOM 3191 C C6    . U   C 3 27  ? 138.289 121.600 127.188 1.00 37.62  ? 1   U   B C6    1 
ATOM 3192 P P     . C   C 3 28  ? 134.644 121.135 132.402 1.00 37.21  ? 2   C   B P     1 
ATOM 3193 O OP1   . C   C 3 28  ? 134.935 121.422 133.827 1.00 37.21  ? 2   C   B OP1   1 
ATOM 3194 O OP2   . C   C 3 28  ? 134.879 119.772 131.865 1.00 37.21  ? 2   C   B OP2   1 
ATOM 3195 O "O5'" . C   C 3 28  ? 133.119 121.509 132.142 1.00 37.21  ? 2   C   B "O5'" 1 
ATOM 3196 C "C5'" . C   C 3 28  ? 132.345 120.788 131.196 1.00 37.21  ? 2   C   B "C5'" 1 
ATOM 3197 C "C4'" . C   C 3 28  ? 131.643 121.715 130.238 1.00 37.21  ? 2   C   B "C4'" 1 
ATOM 3198 O "O4'" . C   C 3 28  ? 132.609 122.306 129.330 1.00 37.21  ? 2   C   B "O4'" 1 
ATOM 3199 C "C3'" . C   C 3 28  ? 130.625 121.065 129.318 1.00 37.21  ? 2   C   B "C3'" 1 
ATOM 3200 O "O3'" . C   C 3 28  ? 129.371 120.863 129.943 1.00 37.21  ? 2   C   B "O3'" 1 
ATOM 3201 C "C2'" . C   C 3 28  ? 130.575 122.030 128.142 1.00 37.21  ? 2   C   B "C2'" 1 
ATOM 3202 O "O2'" . C   C 3 28  ? 129.788 123.168 128.460 1.00 37.21  ? 2   C   B "O2'" 1 
ATOM 3203 C "C1'" . C   C 3 28  ? 132.035 122.466 128.050 1.00 37.21  ? 2   C   B "C1'" 1 
ATOM 3204 N N1    . C   C 3 28  ? 132.805 121.648 127.086 1.00 37.21  ? 2   C   B N1    1 
ATOM 3205 C C2    . C   C 3 28  ? 132.668 121.882 125.717 1.00 37.21  ? 2   C   B C2    1 
ATOM 3206 O O2    . C   C 3 28  ? 131.897 122.769 125.327 1.00 37.21  ? 2   C   B O2    1 
ATOM 3207 N N3    . C   C 3 28  ? 133.380 121.131 124.847 1.00 37.21  ? 2   C   B N3    1 
ATOM 3208 C C4    . C   C 3 28  ? 134.204 120.184 125.294 1.00 37.21  ? 2   C   B C4    1 
ATOM 3209 N N4    . C   C 3 28  ? 134.886 119.468 124.398 1.00 37.21  ? 2   C   B N4    1 
ATOM 3210 C C5    . C   C 3 28  ? 134.366 119.927 126.682 1.00 37.21  ? 2   C   B C5    1 
ATOM 3211 C C6    . C   C 3 28  ? 133.654 120.676 127.530 1.00 37.21  ? 2   C   B C6    1 
ATOM 3212 P P     . C   C 3 29  ? 128.463 119.604 129.536 1.00 36.89  ? 3   C   B P     1 
ATOM 3213 O OP1   . C   C 3 29  ? 127.349 119.502 130.512 1.00 36.89  ? 3   C   B OP1   1 
ATOM 3214 O OP2   . C   C 3 29  ? 129.367 118.446 129.322 1.00 36.89  ? 3   C   B OP2   1 
ATOM 3215 O "O5'" . C   C 3 29  ? 127.848 120.017 128.126 1.00 36.89  ? 3   C   B "O5'" 1 
ATOM 3216 C "C5'" . C   C 3 29  ? 127.070 121.196 127.988 1.00 36.89  ? 3   C   B "C5'" 1 
ATOM 3217 C "C4'" . C   C 3 29  ? 126.786 121.503 126.540 1.00 36.89  ? 3   C   B "C4'" 1 
ATOM 3218 O "O4'" . C   C 3 29  ? 128.017 121.858 125.858 1.00 36.89  ? 3   C   B "O4'" 1 
ATOM 3219 C "C3'" . C   C 3 29  ? 126.232 120.354 125.716 1.00 36.89  ? 3   C   B "C3'" 1 
ATOM 3220 O "O3'" . C   C 3 29  ? 124.843 120.159 125.904 1.00 36.89  ? 3   C   B "O3'" 1 
ATOM 3221 C "C2'" . C   C 3 29  ? 126.608 120.754 124.297 1.00 36.89  ? 3   C   B "C2'" 1 
ATOM 3222 O "O2'" . C   C 3 29  ? 125.721 121.747 123.803 1.00 36.89  ? 3   C   B "O2'" 1 
ATOM 3223 C "C1'" . C   C 3 29  ? 127.975 121.401 124.522 1.00 36.89  ? 3   C   B "C1'" 1 
ATOM 3224 N N1    . C   C 3 29  ? 129.085 120.445 124.312 1.00 36.89  ? 3   C   B N1    1 
ATOM 3225 C C2    . C   C 3 29  ? 129.479 120.143 123.008 1.00 36.89  ? 3   C   B C2    1 
ATOM 3226 O O2    . C   C 3 29  ? 128.888 120.680 122.059 1.00 36.89  ? 3   C   B O2    1 
ATOM 3227 N N3    . C   C 3 29  ? 130.495 119.274 122.807 1.00 36.89  ? 3   C   B N3    1 
ATOM 3228 C C4    . C   C 3 29  ? 131.110 118.716 123.847 1.00 36.89  ? 3   C   B C4    1 
ATOM 3229 N N4    . C   C 3 29  ? 132.106 117.865 123.600 1.00 36.89  ? 3   C   B N4    1 
ATOM 3230 C C5    . C   C 3 29  ? 130.731 119.006 125.187 1.00 36.89  ? 3   C   B C5    1 
ATOM 3231 C C6    . C   C 3 29  ? 129.725 119.868 125.371 1.00 36.89  ? 3   C   B C6    1 
ATOM 3232 P P     . C   C 3 30  ? 124.210 118.691 125.755 1.00 37.32  ? 4   C   B P     1 
ATOM 3233 O OP1   . C   C 3 30  ? 122.870 118.704 126.393 1.00 37.32  ? 4   C   B OP1   1 
ATOM 3234 O OP2   . C   C 3 30  ? 125.228 117.700 126.185 1.00 37.32  ? 4   C   B OP2   1 
ATOM 3235 O "O5'" . C   C 3 30  ? 124.007 118.524 124.186 1.00 37.32  ? 4   C   B "O5'" 1 
ATOM 3236 C "C5'" . C   C 3 30  ? 123.330 119.516 123.431 1.00 37.32  ? 4   C   B "C5'" 1 
ATOM 3237 C "C4'" . C   C 3 30  ? 123.526 119.306 121.953 1.00 37.32  ? 4   C   B "C4'" 1 
ATOM 3238 O "O4'" . C   C 3 30  ? 124.914 119.533 121.600 1.00 37.32  ? 4   C   B "O4'" 1 
ATOM 3239 C "C3'" . C   C 3 30  ? 123.249 117.903 121.446 1.00 37.32  ? 4   C   B "C3'" 1 
ATOM 3240 O "O3'" . C   C 3 30  ? 121.870 117.633 121.274 1.00 37.32  ? 4   C   B "O3'" 1 
ATOM 3241 C "C2'" . C   C 3 30  ? 124.056 117.853 120.157 1.00 37.32  ? 4   C   B "C2'" 1 
ATOM 3242 O "O2'" . C   C 3 30  ? 123.378 118.537 119.113 1.00 37.32  ? 4   C   B "O2'" 1 
ATOM 3243 C "C1'" . C   C 3 30  ? 125.289 118.668 120.547 1.00 37.32  ? 4   C   B "C1'" 1 
ATOM 3244 N N1    . C   C 3 30  ? 126.399 117.805 121.008 1.00 37.32  ? 4   C   B N1    1 
ATOM 3245 C C2    . C   C 3 30  ? 127.200 117.185 120.050 1.00 37.32  ? 4   C   B C2    1 
ATOM 3246 O O2    . C   C 3 30  ? 126.955 117.380 118.850 1.00 37.32  ? 4   C   B O2    1 
ATOM 3247 N N3    . C   C 3 30  ? 128.220 116.391 120.449 1.00 37.32  ? 4   C   B N3    1 
ATOM 3248 C C4    . C   C 3 30  ? 128.452 116.207 121.748 1.00 37.32  ? 4   C   B C4    1 
ATOM 3249 N N4    . C   C 3 30  ? 129.466 115.415 122.099 1.00 37.32  ? 4   C   B N4    1 
ATOM 3250 C C5    . C   C 3 30  ? 127.649 116.827 122.747 1.00 37.32  ? 4   C   B C5    1 
ATOM 3251 C C6    . C   C 3 30  ? 126.644 117.609 122.337 1.00 37.32  ? 4   C   B C6    1 
ATOM 3252 P P     . C   C 3 31  ? 121.303 116.162 121.574 1.00 41.26  ? 5   C   B P     1 
ATOM 3253 O OP1   . C   C 3 31  ? 119.822 116.213 121.494 1.00 41.26  ? 5   C   B OP1   1 
ATOM 3254 O OP2   . C   C 3 31  ? 121.956 115.657 122.808 1.00 41.26  ? 5   C   B OP2   1 
ATOM 3255 O "O5'" . C   C 3 31  ? 121.835 115.296 120.349 1.00 41.26  ? 5   C   B "O5'" 1 
ATOM 3256 C "C5'" . C   C 3 31  ? 121.496 115.652 119.019 1.00 41.26  ? 5   C   B "C5'" 1 
ATOM 3257 C "C4'" . C   C 3 31  ? 122.342 114.921 118.007 1.00 41.26  ? 5   C   B "C4'" 1 
ATOM 3258 O "O4'" . C   C 3 31  ? 123.738 115.284 118.154 1.00 41.26  ? 5   C   B "O4'" 1 
ATOM 3259 C "C3'" . C   C 3 31  ? 122.354 113.407 118.101 1.00 41.26  ? 5   C   B "C3'" 1 
ATOM 3260 O "O3'" . C   C 3 31  ? 121.193 112.805 117.558 1.00 41.26  ? 5   C   B "O3'" 1 
ATOM 3261 C "C2'" . C   C 3 31  ? 123.632 113.048 117.357 1.00 41.26  ? 5   C   B "C2'" 1 
ATOM 3262 O "O2'" . C   C 3 31  ? 123.434 113.122 115.953 1.00 41.26  ? 5   C   B "O2'" 1 
ATOM 3263 C "C1'" . C   C 3 31  ? 124.554 114.195 117.775 1.00 41.26  ? 5   C   B "C1'" 1 
ATOM 3264 N N1    . C   C 3 31  ? 125.422 113.818 118.913 1.00 41.26  ? 5   C   B N1    1 
ATOM 3265 C C2    . C   C 3 31  ? 126.567 113.067 118.646 1.00 41.26  ? 5   C   B C2    1 
ATOM 3266 O O2    . C   C 3 31  ? 126.820 112.748 117.475 1.00 41.26  ? 5   C   B O2    1 
ATOM 3267 N N3    . C   C 3 31  ? 127.376 112.704 119.666 1.00 41.26  ? 5   C   B N3    1 
ATOM 3268 C C4    . C   C 3 31  ? 127.075 113.063 120.912 1.00 41.26  ? 5   C   B C4    1 
ATOM 3269 N N4    . C   C 3 31  ? 127.906 112.682 121.884 1.00 41.26  ? 5   C   B N4    1 
ATOM 3270 C C5    . C   C 3 31  ? 125.912 113.828 121.214 1.00 41.26  ? 5   C   B C5    1 
ATOM 3271 C C6    . C   C 3 31  ? 125.121 114.180 120.195 1.00 41.26  ? 5   C   B C6    1 
ATOM 3272 P P     . U   C 3 32  ? 120.682 111.394 118.127 1.00 49.78  ? 6   U   B P     1 
ATOM 3273 O OP1   . U   C 3 32  ? 119.316 111.155 117.598 1.00 49.78  ? 6   U   B OP1   1 
ATOM 3274 O OP2   . U   C 3 32  ? 120.917 111.375 119.592 1.00 49.78  ? 6   U   B OP2   1 
ATOM 3275 O "O5'" . U   C 3 32  ? 121.661 110.334 117.455 1.00 49.78  ? 6   U   B "O5'" 1 
ATOM 3276 C "C5'" . U   C 3 32  ? 121.710 110.191 116.045 1.00 49.78  ? 6   U   B "C5'" 1 
ATOM 3277 C "C4'" . U   C 3 32  ? 122.965 109.487 115.595 1.00 49.78  ? 6   U   B "C4'" 1 
ATOM 3278 O "O4'" . U   C 3 32  ? 124.126 110.134 116.168 1.00 49.78  ? 6   U   B "O4'" 1 
ATOM 3279 C "C3'" . U   C 3 32  ? 123.112 108.031 116.007 1.00 49.78  ? 6   U   B "C3'" 1 
ATOM 3280 O "O3'" . U   C 3 32  ? 122.357 107.163 115.175 1.00 49.78  ? 6   U   B "O3'" 1 
ATOM 3281 C "C2'" . U   C 3 32  ? 124.621 107.820 115.936 1.00 49.78  ? 6   U   B "C2'" 1 
ATOM 3282 O "O2'" . U   C 3 32  ? 125.037 107.615 114.594 1.00 49.78  ? 6   U   B "O2'" 1 
ATOM 3283 C "C1'" . U   C 3 32  ? 125.142 109.184 116.399 1.00 49.78  ? 6   U   B "C1'" 1 
ATOM 3284 N N1    . U   C 3 32  ? 125.492 109.207 117.837 1.00 49.78  ? 6   U   B N1    1 
ATOM 3285 C C2    . U   C 3 32  ? 126.734 108.727 118.204 1.00 49.78  ? 6   U   B C2    1 
ATOM 3286 O O2    . U   C 3 32  ? 127.535 108.281 117.402 1.00 49.78  ? 6   U   B O2    1 
ATOM 3287 N N3    . U   C 3 32  ? 127.001 108.781 119.548 1.00 49.78  ? 6   U   B N3    1 
ATOM 3288 C C4    . U   C 3 32  ? 126.174 109.262 120.540 1.00 49.78  ? 6   U   B C4    1 
ATOM 3289 O O4    . U   C 3 32  ? 126.558 109.245 121.710 1.00 49.78  ? 6   U   B O4    1 
ATOM 3290 C C5    . U   C 3 32  ? 124.911 109.746 120.078 1.00 49.78  ? 6   U   B C5    1 
ATOM 3291 C C6    . U   C 3 32  ? 124.623 109.704 118.775 1.00 49.78  ? 6   U   B C6    1 
ATOM 3292 P P     . A   C 3 33  ? 122.622 105.576 115.133 1.00 64.32  ? 7   A   B P     1 
ATOM 3293 O OP1   . A   C 3 33  ? 123.718 105.311 114.170 1.00 64.32  ? 7   A   B OP1   1 
ATOM 3294 O OP2   . A   C 3 33  ? 121.308 104.913 114.940 1.00 64.32  ? 7   A   B OP2   1 
ATOM 3295 O "O5'" . A   C 3 33  ? 123.138 105.200 116.590 1.00 64.32  ? 7   A   B "O5'" 1 
ATOM 3296 C "C5'" . A   C 3 33  ? 123.510 103.866 116.901 1.00 64.32  ? 7   A   B "C5'" 1 
ATOM 3297 C "C4'" . A   C 3 33  ? 124.974 103.625 116.640 1.00 64.32  ? 7   A   B "C4'" 1 
ATOM 3298 O "O4'" . A   C 3 33  ? 125.736 104.792 117.042 1.00 64.32  ? 7   A   B "O4'" 1 
ATOM 3299 C "C3'" . A   C 3 33  ? 125.605 102.476 117.414 1.00 64.32  ? 7   A   B "C3'" 1 
ATOM 3300 O "O3'" . A   C 3 33  ? 125.392 101.215 116.804 1.00 64.32  ? 7   A   B "O3'" 1 
ATOM 3301 C "C2'" . A   C 3 33  ? 127.071 102.879 117.480 1.00 64.32  ? 7   A   B "C2'" 1 
ATOM 3302 O "O2'" . A   C 3 33  ? 127.727 102.587 116.255 1.00 64.32  ? 7   A   B "O2'" 1 
ATOM 3303 C "C1'" . A   C 3 33  ? 126.961 104.397 117.618 1.00 64.32  ? 7   A   B "C1'" 1 
ATOM 3304 N N9    . A   C 3 33  ? 126.963 104.834 119.027 1.00 64.32  ? 7   A   B N9    1 
ATOM 3305 C C8    . A   C 3 33  ? 125.961 105.504 119.684 1.00 64.32  ? 7   A   B C8    1 
ATOM 3306 N N7    . A   C 3 33  ? 126.234 105.772 120.936 1.00 64.32  ? 7   A   B N7    1 
ATOM 3307 C C5    . A   C 3 33  ? 127.504 105.246 121.115 1.00 64.32  ? 7   A   B C5    1 
ATOM 3308 C C6    . A   C 3 33  ? 128.358 105.205 122.230 1.00 64.32  ? 7   A   B C6    1 
ATOM 3309 N N6    . A   C 3 33  ? 128.043 105.723 123.419 1.00 64.32  ? 7   A   B N6    1 
ATOM 3310 N N1    . A   C 3 33  ? 129.559 104.607 122.079 1.00 64.32  ? 7   A   B N1    1 
ATOM 3311 C C2    . A   C 3 33  ? 129.871 104.087 120.885 1.00 64.32  ? 7   A   B C2    1 
ATOM 3312 N N3    . A   C 3 33  ? 129.156 104.065 119.763 1.00 64.32  ? 7   A   B N3    1 
ATOM 3313 C C4    . A   C 3 33  ? 127.969 104.667 119.947 1.00 64.32  ? 7   A   B C4    1 
ATOM 3314 P P     . C   C 3 34  ? 124.615 100.051 117.593 1.00 77.09  ? 8   C   B P     1 
ATOM 3315 O OP1   . C   C 3 34  ? 124.099 99.084  116.591 1.00 77.09  ? 8   C   B OP1   1 
ATOM 3316 O OP2   . C   C 3 34  ? 123.670 100.692 118.542 1.00 77.09  ? 8   C   B OP2   1 
ATOM 3317 O "O5'" . C   C 3 34  ? 125.755 99.321  118.435 1.00 77.09  ? 8   C   B "O5'" 1 
ATOM 3318 C "C5'" . C   C 3 34  ? 126.765 98.558  117.791 1.00 77.09  ? 8   C   B "C5'" 1 
ATOM 3319 C "C4'" . C   C 3 34  ? 128.032 98.511  118.608 1.00 77.09  ? 8   C   B "C4'" 1 
ATOM 3320 O "O4'" . C   C 3 34  ? 128.416 99.860  118.984 1.00 77.09  ? 8   C   B "O4'" 1 
ATOM 3321 C "C3'" . C   C 3 34  ? 127.950 97.767  119.934 1.00 77.09  ? 8   C   B "C3'" 1 
ATOM 3322 O "O3'" . C   C 3 34  ? 128.083 96.363  119.792 1.00 77.09  ? 8   C   B "O3'" 1 
ATOM 3323 C "C2'" . C   C 3 34  ? 129.072 98.404  120.743 1.00 77.09  ? 8   C   B "C2'" 1 
ATOM 3324 O "O2'" . C   C 3 34  ? 130.330 97.871  120.359 1.00 77.09  ? 8   C   B "O2'" 1 
ATOM 3325 C "C1'" . C   C 3 34  ? 128.999 99.856  120.270 1.00 77.09  ? 8   C   B "C1'" 1 
ATOM 3326 N N1    . C   C 3 34  ? 128.171 100.695 121.167 1.00 77.09  ? 8   C   B N1    1 
ATOM 3327 C C2    . C   C 3 34  ? 128.764 101.247 122.304 1.00 77.09  ? 8   C   B C2    1 
ATOM 3328 O O2    . C   C 3 34  ? 129.961 101.019 122.528 1.00 77.09  ? 8   C   B O2    1 
ATOM 3329 N N3    . C   C 3 34  ? 128.017 102.017 123.129 1.00 77.09  ? 8   C   B N3    1 
ATOM 3330 C C4    . C   C 3 34  ? 126.730 102.242 122.856 1.00 77.09  ? 8   C   B C4    1 
ATOM 3331 N N4    . C   C 3 34  ? 126.033 103.006 123.698 1.00 77.09  ? 8   C   B N4    1 
ATOM 3332 C C5    . C   C 3 34  ? 126.101 101.692 121.704 1.00 77.09  ? 8   C   B C5    1 
ATOM 3333 C C6    . C   C 3 34  ? 126.853 100.934 120.896 1.00 77.09  ? 8   C   B C6    1 
ATOM 3334 P P     . G   C 3 35  ? 127.497 95.378  120.918 1.00 98.92  ? 9   G   B P     1 
ATOM 3335 O OP1   . G   C 3 35  ? 127.503 93.998  120.370 1.00 98.92  ? 9   G   B OP1   1 
ATOM 3336 O OP2   . G   C 3 35  ? 126.230 95.960  121.426 1.00 98.92  ? 9   G   B OP2   1 
ATOM 3337 O "O5'" . G   C 3 35  ? 128.571 95.445  122.093 1.00 98.92  ? 9   G   B "O5'" 1 
ATOM 3338 C "C5'" . G   C 3 35  ? 128.313 94.831  123.348 1.00 98.92  ? 9   G   B "C5'" 1 
ATOM 3339 C "C4'" . G   C 3 35  ? 129.399 95.135  124.351 1.00 98.92  ? 9   G   B "C4'" 1 
ATOM 3340 O "O4'" . G   C 3 35  ? 129.690 96.556  124.347 1.00 98.92  ? 9   G   B "O4'" 1 
ATOM 3341 C "C3'" . G   C 3 35  ? 129.064 94.832  125.803 1.00 98.92  ? 9   G   B "C3'" 1 
ATOM 3342 O "O3'" . G   C 3 35  ? 129.219 93.463  126.135 1.00 98.92  ? 9   G   B "O3'" 1 
ATOM 3343 C "C2'" . G   C 3 35  ? 130.009 95.753  126.563 1.00 98.92  ? 9   G   B "C2'" 1 
ATOM 3344 O "O2'" . G   C 3 35  ? 131.315 95.197  126.616 1.00 98.92  ? 9   G   B "O2'" 1 
ATOM 3345 C "C1'" . G   C 3 35  ? 130.043 96.978  125.648 1.00 98.92  ? 9   G   B "C1'" 1 
ATOM 3346 N N9    . G   C 3 35  ? 129.113 98.038  126.089 1.00 98.92  ? 9   G   B N9    1 
ATOM 3347 C C8    . G   C 3 35  ? 129.428 99.075  126.933 1.00 98.92  ? 9   G   B C8    1 
ATOM 3348 N N7    . G   C 3 35  ? 128.427 99.874  127.172 1.00 98.92  ? 9   G   B N7    1 
ATOM 3349 C C5    . G   C 3 35  ? 127.379 99.333  126.443 1.00 98.92  ? 9   G   B C5    1 
ATOM 3350 C C6    . G   C 3 35  ? 126.036 99.772  126.314 1.00 98.92  ? 9   G   B C6    1 
ATOM 3351 O O6    . G   C 3 35  ? 125.493 100.755 126.832 1.00 98.92  ? 9   G   B O6    1 
ATOM 3352 N N1    . G   C 3 35  ? 125.302 98.937  125.480 1.00 98.92  ? 9   G   B N1    1 
ATOM 3353 C C2    . G   C 3 35  ? 125.795 97.822  124.851 1.00 98.92  ? 9   G   B C2    1 
ATOM 3354 N N2    . G   C 3 35  ? 124.930 97.142  124.084 1.00 98.92  ? 9   G   B N2    1 
ATOM 3355 N N3    . G   C 3 35  ? 127.045 97.403  124.964 1.00 98.92  ? 9   G   B N3    1 
ATOM 3356 C C4    . G   C 3 35  ? 127.781 98.196  125.772 1.00 98.92  ? 9   G   B C4    1 
ATOM 3357 P P     . U   C 3 36  ? 128.123 92.724  127.050 1.00 113.57 ? 10  U   B P     1 
ATOM 3358 O OP1   . U   C 3 36  ? 128.570 91.323  127.260 1.00 113.57 ? 10  U   B OP1   1 
ATOM 3359 O OP2   . U   C 3 36  ? 126.784 92.987  126.465 1.00 113.57 ? 10  U   B OP2   1 
ATOM 3360 O "O5'" . U   C 3 36  ? 128.207 93.482  128.449 1.00 113.57 ? 10  U   B "O5'" 1 
ATOM 3361 C "C5'" . U   C 3 36  ? 129.381 93.420  129.245 1.00 113.57 ? 10  U   B "C5'" 1 
ATOM 3362 C "C4'" . U   C 3 36  ? 129.222 94.199  130.527 1.00 113.57 ? 10  U   B "C4'" 1 
ATOM 3363 O "O4'" . U   C 3 36  ? 128.923 95.585  130.229 1.00 113.57 ? 10  U   B "O4'" 1 
ATOM 3364 C "C3'" . U   C 3 36  ? 128.084 93.762  131.437 1.00 113.57 ? 10  U   B "C3'" 1 
ATOM 3365 O "O3'" . U   C 3 36  ? 128.416 92.633  132.226 1.00 113.57 ? 10  U   B "O3'" 1 
ATOM 3366 C "C2'" . U   C 3 36  ? 127.796 95.018  132.257 1.00 113.57 ? 10  U   B "C2'" 1 
ATOM 3367 O "O2'" . U   C 3 36  ? 128.686 95.113  133.359 1.00 113.57 ? 10  U   B "O2'" 1 
ATOM 3368 C "C1'" . U   C 3 36  ? 128.136 96.136  131.262 1.00 113.57 ? 10  U   B "C1'" 1 
ATOM 3369 N N1    . U   C 3 36  ? 126.949 96.827  130.693 1.00 113.57 ? 10  U   B N1    1 
ATOM 3370 C C2    . U   C 3 36  ? 126.015 96.179  129.895 1.00 113.57 ? 10  U   B C2    1 
ATOM 3371 O O2    . U   C 3 36  ? 126.073 95.009  129.564 1.00 113.57 ? 10  U   B O2    1 
ATOM 3372 N N3    . U   C 3 36  ? 124.980 96.971  129.458 1.00 113.57 ? 10  U   B N3    1 
ATOM 3373 C C4    . U   C 3 36  ? 124.766 98.305  129.730 1.00 113.57 ? 10  U   B C4    1 
ATOM 3374 O O4    . U   C 3 36  ? 123.779 98.874  129.260 1.00 113.57 ? 10  U   B O4    1 
ATOM 3375 C C5    . U   C 3 36  ? 125.761 98.901  130.563 1.00 113.57 ? 10  U   B C5    1 
ATOM 3376 C C6    . U   C 3 36  ? 126.782 98.158  131.000 1.00 113.57 ? 10  U   B C6    1 
ATOM 3377 P P     . G   C 3 37  ? 127.630 91.246  132.026 1.00 119.65 ? 11  G   B P     1 
ATOM 3378 O OP1   . G   C 3 37  ? 128.637 90.170  131.845 1.00 119.65 ? 11  G   B OP1   1 
ATOM 3379 O OP2   . G   C 3 37  ? 126.585 91.455  130.991 1.00 119.65 ? 11  G   B OP2   1 
ATOM 3380 O "O5'" . G   C 3 37  ? 126.901 91.012  133.422 1.00 119.65 ? 11  G   B "O5'" 1 
ATOM 3381 C "C5'" . G   C 3 37  ? 125.518 90.699  133.478 1.00 119.65 ? 11  G   B "C5'" 1 
ATOM 3382 C "C4'" . G   C 3 37  ? 124.830 91.446  134.592 1.00 119.65 ? 11  G   B "C4'" 1 
ATOM 3383 O "O4'" . G   C 3 37  ? 125.191 92.851  134.532 1.00 119.65 ? 11  G   B "O4'" 1 
ATOM 3384 C "C3'" . G   C 3 37  ? 123.310 91.452  134.550 1.00 119.65 ? 11  G   B "C3'" 1 
ATOM 3385 O "O3'" . G   C 3 37  ? 122.737 90.271  135.085 1.00 119.65 ? 11  G   B "O3'" 1 
ATOM 3386 C "C2'" . G   C 3 37  ? 122.960 92.710  135.334 1.00 119.65 ? 11  G   B "C2'" 1 
ATOM 3387 O "O2'" . G   C 3 37  ? 123.065 92.477  136.730 1.00 119.65 ? 11  G   B "O2'" 1 
ATOM 3388 C "C1'" . G   C 3 37  ? 124.091 93.649  134.914 1.00 119.65 ? 11  G   B "C1'" 1 
ATOM 3389 N N9    . G   C 3 37  ? 123.710 94.495  133.769 1.00 119.65 ? 11  G   B N9    1 
ATOM 3390 C C8    . G   C 3 37  ? 124.034 94.299  132.449 1.00 119.65 ? 11  G   B C8    1 
ATOM 3391 N N7    . G   C 3 37  ? 123.549 95.219  131.661 1.00 119.65 ? 11  G   B N7    1 
ATOM 3392 C C5    . G   C 3 37  ? 122.863 96.074  132.512 1.00 119.65 ? 11  G   B C5    1 
ATOM 3393 C C6    . G   C 3 37  ? 122.130 97.257  132.236 1.00 119.65 ? 11  G   B C6    1 
ATOM 3394 O O6    . G   C 3 37  ? 121.932 97.808  131.146 1.00 119.65 ? 11  G   B O6    1 
ATOM 3395 N N1    . G   C 3 37  ? 121.597 97.808  133.395 1.00 119.65 ? 11  G   B N1    1 
ATOM 3396 C C2    . G   C 3 37  ? 121.746 97.293  134.658 1.00 119.65 ? 11  G   B C2    1 
ATOM 3397 N N2    . G   C 3 37  ? 121.153 97.974  135.649 1.00 119.65 ? 11  G   B N2    1 
ATOM 3398 N N3    . G   C 3 37  ? 122.426 96.191  134.930 1.00 119.65 ? 11  G   B N3    1 
ATOM 3399 C C4    . G   C 3 37  ? 122.953 95.639  133.817 1.00 119.65 ? 11  G   B C4    1 
ATOM 3400 P P     . DC  D 4 4   ? 126.114 156.909 114.850 1.00 55.36  ? -6  DC  D P     1 
ATOM 3401 O OP1   . DC  D 4 4   ? 126.477 157.874 113.789 1.00 55.36  ? -6  DC  D OP1   1 
ATOM 3402 O OP2   . DC  D 4 4   ? 125.542 157.392 116.126 1.00 55.36  ? -6  DC  D OP2   1 
ATOM 3403 O "O5'" . DC  D 4 4   ? 125.113 155.816 114.247 1.00 55.36  ? -6  DC  D "O5'" 1 
ATOM 3404 C "C5'" . DC  D 4 4   ? 123.705 155.995 114.367 1.00 55.36  ? -6  DC  D "C5'" 1 
ATOM 3405 C "C4'" . DC  D 4 4   ? 122.953 154.847 113.714 1.00 55.36  ? -6  DC  D "C4'" 1 
ATOM 3406 O "O4'" . DC  D 4 4   ? 123.300 154.778 112.307 1.00 55.36  ? -6  DC  D "O4'" 1 
ATOM 3407 C "C3'" . DC  D 4 4   ? 123.252 153.467 114.292 1.00 55.36  ? -6  DC  D "C3'" 1 
ATOM 3408 O "O3'" . DC  D 4 4   ? 122.072 152.677 114.309 1.00 55.36  ? -6  DC  D "O3'" 1 
ATOM 3409 C "C2'" . DC  D 4 4   ? 124.288 152.905 113.326 1.00 55.36  ? -6  DC  D "C2'" 1 
ATOM 3410 C "C1'" . DC  D 4 4   ? 123.844 153.511 112.003 1.00 55.36  ? -6  DC  D "C1'" 1 
ATOM 3411 N N1    . DC  D 4 4   ? 124.962 153.702 111.043 1.00 55.36  ? -6  DC  D N1    1 
ATOM 3412 C C2    . DC  D 4 4   ? 124.900 153.109 109.779 1.00 55.36  ? -6  DC  D C2    1 
ATOM 3413 O O2    . DC  D 4 4   ? 123.908 152.435 109.476 1.00 55.36  ? -6  DC  D O2    1 
ATOM 3414 N N3    . DC  D 4 4   ? 125.932 153.291 108.918 1.00 55.36  ? -6  DC  D N3    1 
ATOM 3415 C C4    . DC  D 4 4   ? 126.984 154.024 109.283 1.00 55.36  ? -6  DC  D C4    1 
ATOM 3416 N N4    . DC  D 4 4   ? 127.977 154.177 108.401 1.00 55.36  ? -6  DC  D N4    1 
ATOM 3417 C C5    . DC  D 4 4   ? 127.065 154.635 110.568 1.00 55.36  ? -6  DC  D C5    1 
ATOM 3418 C C6    . DC  D 4 4   ? 126.043 154.448 111.407 1.00 55.36  ? -6  DC  D C6    1 
ATOM 3419 P P     . DC  D 4 5   ? 122.069 151.247 115.042 1.00 52.02  ? -5  DC  D P     1 
ATOM 3420 O OP1   . DC  D 4 5   ? 120.680 150.954 115.455 1.00 52.02  ? -5  DC  D OP1   1 
ATOM 3421 O OP2   . DC  D 4 5   ? 123.150 151.260 116.051 1.00 52.02  ? -5  DC  D OP2   1 
ATOM 3422 O "O5'" . DC  D 4 5   ? 122.489 150.224 113.887 1.00 52.02  ? -5  DC  D "O5'" 1 
ATOM 3423 C "C5'" . DC  D 4 5   ? 121.683 150.101 112.721 1.00 52.02  ? -5  DC  D "C5'" 1 
ATOM 3424 C "C4'" . DC  D 4 5   ? 122.314 149.145 111.724 1.00 52.02  ? -5  DC  D "C4'" 1 
ATOM 3425 O "O4'" . DC  D 4 5   ? 123.438 149.790 111.071 1.00 52.02  ? -5  DC  D "O4'" 1 
ATOM 3426 C "C3'" . DC  D 4 5   ? 122.856 147.848 112.325 1.00 52.02  ? -5  DC  D "C3'" 1 
ATOM 3427 O "O3'" . DC  D 4 5   ? 122.533 146.757 111.481 1.00 52.02  ? -5  DC  D "O3'" 1 
ATOM 3428 C "C2'" . DC  D 4 5   ? 124.363 148.091 112.369 1.00 52.02  ? -5  DC  D "C2'" 1 
ATOM 3429 C "C1'" . DC  D 4 5   ? 124.560 148.943 111.127 1.00 52.02  ? -5  DC  D "C1'" 1 
ATOM 3430 N N1    . DC  D 4 5   ? 125.784 149.784 111.168 1.00 52.02  ? -5  DC  D N1    1 
ATOM 3431 C C2    . DC  D 4 5   ? 126.395 150.170 109.973 1.00 52.02  ? -5  DC  D C2    1 
ATOM 3432 O O2    . DC  D 4 5   ? 125.903 149.804 108.900 1.00 52.02  ? -5  DC  D O2    1 
ATOM 3433 N N3    . DC  D 4 5   ? 127.509 150.939 110.025 1.00 52.02  ? -5  DC  D N3    1 
ATOM 3434 C C4    . DC  D 4 5   ? 128.007 151.314 111.202 1.00 52.02  ? -5  DC  D C4    1 
ATOM 3435 N N4    . DC  D 4 5   ? 129.109 152.072 111.202 1.00 52.02  ? -5  DC  D N4    1 
ATOM 3436 C C5    . DC  D 4 5   ? 127.398 150.930 112.433 1.00 52.02  ? -5  DC  D C5    1 
ATOM 3437 C C6    . DC  D 4 5   ? 126.300 150.171 112.369 1.00 52.02  ? -5  DC  D C6    1 
ATOM 3438 P P     . DA  D 4 6   ? 121.252 145.842 111.796 1.00 45.15  ? -4  DA  D P     1 
ATOM 3439 O OP1   . DA  D 4 6   ? 120.183 146.715 112.326 1.00 45.15  ? -4  DA  D OP1   1 
ATOM 3440 O OP2   . DA  D 4 6   ? 121.718 144.687 112.590 1.00 45.15  ? -4  DA  D OP2   1 
ATOM 3441 O "O5'" . DA  D 4 6   ? 120.811 145.297 110.361 1.00 45.15  ? -4  DA  D "O5'" 1 
ATOM 3442 C "C5'" . DA  D 4 6   ? 121.408 144.122 109.839 1.00 45.15  ? -4  DA  D "C5'" 1 
ATOM 3443 C "C4'" . DA  D 4 6   ? 122.000 144.370 108.464 1.00 45.15  ? -4  DA  D "C4'" 1 
ATOM 3444 O "O4'" . DA  D 4 6   ? 123.023 145.397 108.552 1.00 45.15  ? -4  DA  D "O4'" 1 
ATOM 3445 C "C3'" . DA  D 4 6   ? 122.676 143.151 107.836 1.00 45.15  ? -4  DA  D "C3'" 1 
ATOM 3446 O "O3'" . DA  D 4 6   ? 122.360 143.071 106.455 1.00 45.15  ? -4  DA  D "O3'" 1 
ATOM 3447 C "C2'" . DA  D 4 6   ? 124.160 143.420 108.061 1.00 45.15  ? -4  DA  D "C2'" 1 
ATOM 3448 C "C1'" . DA  D 4 6   ? 124.210 144.933 107.954 1.00 45.15  ? -4  DA  D "C1'" 1 
ATOM 3449 N N9    . DA  D 4 6   ? 125.347 145.521 108.651 1.00 45.15  ? -4  DA  D N9    1 
ATOM 3450 C C8    . DA  D 4 6   ? 125.457 145.759 109.991 1.00 45.15  ? -4  DA  D C8    1 
ATOM 3451 N N7    . DA  D 4 6   ? 126.601 146.296 110.340 1.00 45.15  ? -4  DA  D N7    1 
ATOM 3452 C C5    . DA  D 4 6   ? 127.290 146.415 109.145 1.00 45.15  ? -4  DA  D C5    1 
ATOM 3453 C C6    . DA  D 4 6   ? 128.569 146.913 108.833 1.00 45.15  ? -4  DA  D C6    1 
ATOM 3454 N N6    . DA  D 4 6   ? 129.411 147.404 109.749 1.00 45.15  ? -4  DA  D N6    1 
ATOM 3455 N N1    . DA  D 4 6   ? 128.952 146.887 107.541 1.00 45.15  ? -4  DA  D N1    1 
ATOM 3456 C C2    . DA  D 4 6   ? 128.107 146.397 106.629 1.00 45.15  ? -4  DA  D C2    1 
ATOM 3457 N N3    . DA  D 4 6   ? 126.883 145.902 106.801 1.00 45.15  ? -4  DA  D N3    1 
ATOM 3458 C C4    . DA  D 4 6   ? 126.531 145.941 108.095 1.00 45.15  ? -4  DA  D C4    1 
ATOM 3459 P P     . DA  D 4 7   ? 122.402 141.651 105.708 1.00 40.42  ? -3  DA  D P     1 
ATOM 3460 O OP1   . DA  D 4 7   ? 121.218 141.573 104.826 1.00 40.42  ? -3  DA  D OP1   1 
ATOM 3461 O OP2   . DA  D 4 7   ? 122.621 140.617 106.741 1.00 40.42  ? -3  DA  D OP2   1 
ATOM 3462 O "O5'" . DA  D 4 7   ? 123.724 141.723 104.813 1.00 40.42  ? -3  DA  D "O5'" 1 
ATOM 3463 C "C5'" . DA  D 4 7   ? 123.805 142.651 103.743 1.00 40.42  ? -3  DA  D "C5'" 1 
ATOM 3464 C "C4'" . DA  D 4 7   ? 125.232 142.783 103.242 1.00 40.42  ? -3  DA  D "C4'" 1 
ATOM 3465 O "O4'" . DA  D 4 7   ? 126.071 143.321 104.295 1.00 40.42  ? -3  DA  D "O4'" 1 
ATOM 3466 C "C3'" . DA  D 4 7   ? 125.893 141.476 102.796 1.00 40.42  ? -3  DA  D "C3'" 1 
ATOM 3467 O "O3'" . DA  D 4 7   ? 126.592 141.685 101.574 1.00 40.42  ? -3  DA  D "O3'" 1 
ATOM 3468 C "C2'" . DA  D 4 7   ? 126.847 141.158 103.946 1.00 40.42  ? -3  DA  D "C2'" 1 
ATOM 3469 C "C1'" . DA  D 4 7   ? 127.244 142.550 104.394 1.00 40.42  ? -3  DA  D "C1'" 1 
ATOM 3470 N N9    . DA  D 4 7   ? 127.722 142.608 105.769 1.00 40.42  ? -3  DA  D N9    1 
ATOM 3471 C C8    . DA  D 4 7   ? 127.091 142.129 106.882 1.00 40.42  ? -3  DA  D C8    1 
ATOM 3472 N N7    . DA  D 4 7   ? 127.757 142.328 107.994 1.00 40.42  ? -3  DA  D N7    1 
ATOM 3473 C C5    . DA  D 4 7   ? 128.903 142.987 107.581 1.00 40.42  ? -3  DA  D C5    1 
ATOM 3474 C C6    . DA  D 4 7   ? 130.018 143.480 108.283 1.00 40.42  ? -3  DA  D C6    1 
ATOM 3475 N N6    . DA  D 4 7   ? 130.158 143.375 109.607 1.00 40.42  ? -3  DA  D N6    1 
ATOM 3476 N N1    . DA  D 4 7   ? 130.986 144.088 107.569 1.00 40.42  ? -3  DA  D N1    1 
ATOM 3477 C C2    . DA  D 4 7   ? 130.842 144.192 106.244 1.00 40.42  ? -3  DA  D C2    1 
ATOM 3478 N N3    . DA  D 4 7   ? 129.841 143.769 105.476 1.00 40.42  ? -3  DA  D N3    1 
ATOM 3479 C C4    . DA  D 4 7   ? 128.897 143.168 106.213 1.00 40.42  ? -3  DA  D C4    1 
ATOM 3480 P P     . DT  D 4 8   ? 127.510 140.527 100.946 1.00 41.51  ? -2  DT  D P     1 
ATOM 3481 O OP1   . DT  D 4 8   ? 127.484 140.695 99.478  1.00 41.51  ? -2  DT  D OP1   1 
ATOM 3482 O OP2   . DT  D 4 8   ? 127.108 139.236 101.541 1.00 41.51  ? -2  DT  D OP2   1 
ATOM 3483 O "O5'" . DT  D 4 8   ? 128.981 140.871 101.468 1.00 41.51  ? -2  DT  D "O5'" 1 
ATOM 3484 C "C5'" . DT  D 4 8   ? 129.623 142.066 101.045 1.00 41.51  ? -2  DT  D "C5'" 1 
ATOM 3485 C "C4'" . DT  D 4 8   ? 131.106 142.030 101.368 1.00 41.51  ? -2  DT  D "C4'" 1 
ATOM 3486 O "O4'" . DT  D 4 8   ? 131.300 142.166 102.799 1.00 41.51  ? -2  DT  D "O4'" 1 
ATOM 3487 C "C3'" . DT  D 4 8   ? 131.831 140.741 100.960 1.00 41.51  ? -2  DT  D "C3'" 1 
ATOM 3488 O "O3'" . DT  D 4 8   ? 133.011 141.054 100.236 1.00 41.51  ? -2  DT  D "O3'" 1 
ATOM 3489 C "C2'" . DT  D 4 8   ? 132.159 140.075 102.295 1.00 41.51  ? -2  DT  D "C2'" 1 
ATOM 3490 C "C1'" . DT  D 4 8   ? 132.314 141.281 103.199 1.00 41.51  ? -2  DT  D "C1'" 1 
ATOM 3491 N N1    . DT  D 4 8   ? 132.145 140.975 104.646 1.00 41.51  ? -2  DT  D N1    1 
ATOM 3492 C C2    . DT  D 4 8   ? 133.189 141.215 105.508 1.00 41.51  ? -2  DT  D C2    1 
ATOM 3493 O O2    . DT  D 4 8   ? 134.259 141.671 105.149 1.00 41.51  ? -2  DT  D O2    1 
ATOM 3494 N N3    . DT  D 4 8   ? 132.934 140.903 106.815 1.00 41.51  ? -2  DT  D N3    1 
ATOM 3495 C C4    . DT  D 4 8   ? 131.765 140.383 107.337 1.00 41.51  ? -2  DT  D C4    1 
ATOM 3496 O O4    . DT  D 4 8   ? 131.633 140.134 108.531 1.00 41.51  ? -2  DT  D O4    1 
ATOM 3497 C C5    . DT  D 4 8   ? 130.710 140.155 106.380 1.00 41.51  ? -2  DT  D C5    1 
ATOM 3498 C C7    . DT  D 4 8   ? 129.395 139.594 106.829 1.00 41.51  ? -2  DT  D C7    1 
ATOM 3499 C C6    . DT  D 4 8   ? 130.948 140.459 105.095 1.00 41.51  ? -2  DT  D C6    1 
ATOM 3500 P P     . DT  D 4 9   ? 133.729 139.932 99.341  1.00 45.31  ? -1  DT  D P     1 
ATOM 3501 O OP1   . DT  D 4 9   ? 134.178 140.580 98.090  1.00 45.31  ? -1  DT  D OP1   1 
ATOM 3502 O OP2   . DT  D 4 9   ? 132.819 138.768 99.277  1.00 45.31  ? -1  DT  D OP2   1 
ATOM 3503 O "O5'" . DT  D 4 9   ? 135.011 139.510 100.202 1.00 45.31  ? -1  DT  D "O5'" 1 
ATOM 3504 C "C5'" . DT  D 4 9   ? 136.096 140.421 100.357 1.00 45.31  ? -1  DT  D "C5'" 1 
ATOM 3505 C "C4'" . DT  D 4 9   ? 137.046 139.963 101.452 1.00 45.31  ? -1  DT  D "C4'" 1 
ATOM 3506 O "O4'" . DT  D 4 9   ? 136.346 139.926 102.723 1.00 45.31  ? -1  DT  D "O4'" 1 
ATOM 3507 C "C3'" . DT  D 4 9   ? 137.650 138.572 101.256 1.00 45.31  ? -1  DT  D "C3'" 1 
ATOM 3508 O "O3'" . DT  D 4 9   ? 139.027 138.593 101.592 1.00 45.31  ? -1  DT  D "O3'" 1 
ATOM 3509 C "C2'" . DT  D 4 9   ? 136.852 137.706 102.226 1.00 45.31  ? -1  DT  D "C2'" 1 
ATOM 3510 C "C1'" . DT  D 4 9   ? 136.576 138.689 103.351 1.00 45.31  ? -1  DT  D "C1'" 1 
ATOM 3511 N N1    . DT  D 4 9   ? 135.376 138.343 104.156 1.00 45.31  ? -1  DT  D N1    1 
ATOM 3512 C C2    . DT  D 4 9   ? 135.346 138.657 105.493 1.00 45.31  ? -1  DT  D C2    1 
ATOM 3513 O O2    . DT  D 4 9   ? 136.263 139.215 106.069 1.00 45.31  ? -1  DT  D O2    1 
ATOM 3514 N N3    . DT  D 4 9   ? 134.196 138.292 106.141 1.00 45.31  ? -1  DT  D N3    1 
ATOM 3515 C C4    . DT  D 4 9   ? 133.094 137.663 105.594 1.00 45.31  ? -1  DT  D C4    1 
ATOM 3516 O O4    . DT  D 4 9   ? 132.104 137.375 106.260 1.00 45.31  ? -1  DT  D O4    1 
ATOM 3517 C C5    . DT  D 4 9   ? 133.195 137.359 104.186 1.00 45.31  ? -1  DT  D C5    1 
ATOM 3518 C C7    . DT  D 4 9   ? 132.067 136.674 103.478 1.00 45.31  ? -1  DT  D C7    1 
ATOM 3519 C C6    . DT  D 4 9   ? 134.318 137.709 103.545 1.00 45.31  ? -1  DT  D C6    1 
ATOM 3520 P P     . DC  D 4 10  ? 140.004 137.420 101.091 1.00 49.18  ? 0   DC  D P     1 
ATOM 3521 O OP1   . DC  D 4 10  ? 141.086 138.047 100.302 1.00 49.18  ? 0   DC  D OP1   1 
ATOM 3522 O OP2   . DC  D 4 10  ? 139.173 136.358 100.482 1.00 49.18  ? 0   DC  D OP2   1 
ATOM 3523 O "O5'" . DC  D 4 10  ? 140.630 136.842 102.445 1.00 49.18  ? 0   DC  D "O5'" 1 
ATOM 3524 C "C5'" . DC  D 4 10  ? 141.495 137.654 103.228 1.00 49.18  ? 0   DC  D "C5'" 1 
ATOM 3525 C "C4'" . DC  D 4 10  ? 141.655 137.088 104.628 1.00 49.18  ? 0   DC  D "C4'" 1 
ATOM 3526 O "O4'" . DC  D 4 10  ? 140.385 137.155 105.327 1.00 49.18  ? 0   DC  D "O4'" 1 
ATOM 3527 C "C3'" . DC  D 4 10  ? 142.101 135.624 104.690 1.00 49.18  ? 0   DC  D "C3'" 1 
ATOM 3528 O "O3'" . DC  D 4 10  ? 143.112 135.466 105.676 1.00 49.18  ? 0   DC  D "O3'" 1 
ATOM 3529 C "C2'" . DC  D 4 10  ? 140.823 134.885 105.077 1.00 49.18  ? 0   DC  D "C2'" 1 
ATOM 3530 C "C1'" . DC  D 4 10  ? 140.132 135.920 105.945 1.00 49.18  ? 0   DC  D "C1'" 1 
ATOM 3531 N N1    . DC  D 4 10  ? 138.659 135.728 106.045 1.00 49.18  ? 0   DC  D N1    1 
ATOM 3532 C C2    . DC  D 4 10  ? 137.922 136.485 106.962 1.00 49.18  ? 0   DC  D C2    1 
ATOM 3533 O O2    . DC  D 4 10  ? 138.508 137.310 107.672 1.00 49.18  ? 0   DC  D O2    1 
ATOM 3534 N N3    . DC  D 4 10  ? 136.585 136.293 107.044 1.00 49.18  ? 0   DC  D N3    1 
ATOM 3535 C C4    . DC  D 4 10  ? 135.990 135.395 106.261 1.00 49.18  ? 0   DC  D C4    1 
ATOM 3536 N N4    . DC  D 4 10  ? 134.669 135.240 106.378 1.00 49.18  ? 0   DC  D N4    1 
ATOM 3537 C C5    . DC  D 4 10  ? 136.724 134.612 105.322 1.00 49.18  ? 0   DC  D C5    1 
ATOM 3538 C C6    . DC  D 4 10  ? 138.042 134.809 105.250 1.00 49.18  ? 0   DC  D C6    1 
ATOM 3539 P P     . DT  D 4 11  ? 144.239 134.332 105.511 1.00 54.27  ? 1   DT  D P     1 
ATOM 3540 O OP1   . DT  D 4 11  ? 145.524 135.017 105.251 1.00 54.27  ? 1   DT  D OP1   1 
ATOM 3541 O OP2   . DT  D 4 11  ? 143.741 133.324 104.550 1.00 54.27  ? 1   DT  D OP2   1 
ATOM 3542 O "O5'" . DT  D 4 11  ? 144.306 133.650 106.957 1.00 54.27  ? 1   DT  D "O5'" 1 
ATOM 3543 C "C5'" . DT  D 4 11  ? 144.687 134.425 108.089 1.00 54.27  ? 1   DT  D "C5'" 1 
ATOM 3544 C "C4'" . DT  D 4 11  ? 144.056 133.881 109.359 1.00 54.27  ? 1   DT  D "C4'" 1 
ATOM 3545 O "O4'" . DT  D 4 11  ? 142.609 133.948 109.251 1.00 54.27  ? 1   DT  D "O4'" 1 
ATOM 3546 C "C3'" . DT  D 4 11  ? 144.398 132.424 109.681 1.00 54.27  ? 1   DT  D "C3'" 1 
ATOM 3547 O "O3'" . DT  D 4 11  ? 144.743 132.298 111.055 1.00 54.27  ? 1   DT  D "O3'" 1 
ATOM 3548 C "C2'" . DT  D 4 11  ? 143.108 131.672 109.356 1.00 54.27  ? 1   DT  D "C2'" 1 
ATOM 3549 C "C1'" . DT  D 4 11  ? 142.052 132.723 109.660 1.00 54.27  ? 1   DT  D "C1'" 1 
ATOM 3550 N N1    . DT  D 4 11  ? 140.778 132.523 108.946 1.00 20.00  ? 1   DT  D N1    1 
ATOM 3551 C C2    . DT  D 4 11  ? 139.585 132.615 109.650 1.00 20.00  ? 1   DT  D C2    1 
ATOM 3552 O O2    . DT  D 4 11  ? 139.520 132.869 110.854 1.00 20.00  ? 1   DT  D O2    1 
ATOM 3553 N N3    . DT  D 4 11  ? 138.462 132.400 108.888 1.00 20.00  ? 1   DT  D N3    1 
ATOM 3554 C C4    . DT  D 4 11  ? 138.397 132.108 107.550 1.00 20.00  ? 1   DT  D C4    1 
ATOM 3555 O O4    . DT  D 4 11  ? 137.300 131.954 107.014 1.00 20.00  ? 1   DT  D O4    1 
ATOM 3556 C C5    . DT  D 4 11  ? 139.677 132.008 106.877 1.00 20.00  ? 1   DT  D C5    1 
ATOM 3557 C C7    . DT  D 4 11  ? 139.706 131.690 105.418 1.00 20.00  ? 1   DT  D C7    1 
ATOM 3558 C C6    . DT  D 4 11  ? 140.790 132.211 107.604 1.00 20.00  ? 1   DT  D C6    1 
# 
