data_8W6E
# 
_entry.id   8W6E 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W6E         pdb_00008w6e 10.2210/pdb8w6e/pdb 
WWPDB D_1300040628 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2024-11-27 ? 
2 'Structure model' 1 1 2025-02-26 ? 
3 'Structure model' 1 2 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
4 3 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.pdbx_database_id_DOI'    
7  2 'Structure model' '_citation.title'                   
8  2 'Structure model' '_citation.year'                    
9  3 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 3 'Structure model' '_citation.title'                   
11 3 'Structure model' '_citation_author.identifier_ORCID' 
12 3 'Structure model' '_citation_author.name'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W6E 
_pdbx_database_status.recvd_initial_deposition_date   2023-08-28 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              lupeilong@westlake.edu.cn 
_pdbx_contact_author.name_first         Peilong 
_pdbx_contact_author.name_last          Lu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5894-9268 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Liang, M.F.' 1 0000-0001-6170-9978 
'Zhu, J.Y.'   2 ?                   
'Lu, P.L.'    3 0000-0001-5894-9268 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nature 
_citation.journal_id_ASTM           NATUAS 
_citation.journal_id_CSD            0006 
_citation.journal_id_ISSN           1476-4687 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'De novo design of transmembrane fluorescence-activating proteins.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41586-025-08598-8 
_citation.pdbx_database_id_PubMed   39972138 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhu, J.'   1  ? 
primary 'Liang, M.' 2  ? 
primary 'Sun, K.'   3  ? 
primary 'Wei, Y.'   4  ? 
primary 'Guo, R.'   5  ? 
primary 'Zhang, L.' 6  ? 
primary 'Shi, J.'   7  ? 
primary 'Ma, D.'    8  ? 
primary 'Hu, Q.'    9  ? 
primary 'Huang, G.' 10 ? 
primary 'Lu, P.'    11 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'HBC599 in complex with wFAP1.1'                                                                21460.938 2  ? ? 
? ? 
2 non-polymer syn '4-[(Z)-1-cyano-2-{6-[(2-hydroxyethyl)(methyl)amino]-1-benzothiophen-2-yl}ethenyl]benzonitrile' 359.444   2  ? ? 
? ? 
3 water       nat water                                                                                           18.015    31 ? ? 
? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDEERLKEILEELERIIEEVKRLLEKDERLLREFYRRNVTDKEEFRRVIKLDEEVMKRSEELLKRAEELLRELEELIRRI
PFSEEIRRELEEILRRLKELYEEAKRLMEKAKELTKRIKKIDTTDEKTLREWYEIVRELLERAKEIIEEIERLLRRLLEI
LGLEHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDEERLKEILEELERIIEEVKRLLEKDERLLREFYRRNVTDKEEFRRVIKLDEEVMKRSEELLKRAEELLRELEELIRRI
PFSEEIRRELEEILRRLKELYEEAKRLMEKAKELTKRIKKIDTTDEKTLREWYEIVRELLERAKEIIEEIERLLRRLLEI
LGLEHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '4-[(Z)-1-cyano-2-{6-[(2-hydroxyethyl)(methyl)amino]-1-benzothiophen-2-yl}ethenyl]benzonitrile' KY6 
3 water                                                                                           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   GLU n 
1 4   GLU n 
1 5   ARG n 
1 6   LEU n 
1 7   LYS n 
1 8   GLU n 
1 9   ILE n 
1 10  LEU n 
1 11  GLU n 
1 12  GLU n 
1 13  LEU n 
1 14  GLU n 
1 15  ARG n 
1 16  ILE n 
1 17  ILE n 
1 18  GLU n 
1 19  GLU n 
1 20  VAL n 
1 21  LYS n 
1 22  ARG n 
1 23  LEU n 
1 24  LEU n 
1 25  GLU n 
1 26  LYS n 
1 27  ASP n 
1 28  GLU n 
1 29  ARG n 
1 30  LEU n 
1 31  LEU n 
1 32  ARG n 
1 33  GLU n 
1 34  PHE n 
1 35  TYR n 
1 36  ARG n 
1 37  ARG n 
1 38  ASN n 
1 39  VAL n 
1 40  THR n 
1 41  ASP n 
1 42  LYS n 
1 43  GLU n 
1 44  GLU n 
1 45  PHE n 
1 46  ARG n 
1 47  ARG n 
1 48  VAL n 
1 49  ILE n 
1 50  LYS n 
1 51  LEU n 
1 52  ASP n 
1 53  GLU n 
1 54  GLU n 
1 55  VAL n 
1 56  MET n 
1 57  LYS n 
1 58  ARG n 
1 59  SER n 
1 60  GLU n 
1 61  GLU n 
1 62  LEU n 
1 63  LEU n 
1 64  LYS n 
1 65  ARG n 
1 66  ALA n 
1 67  GLU n 
1 68  GLU n 
1 69  LEU n 
1 70  LEU n 
1 71  ARG n 
1 72  GLU n 
1 73  LEU n 
1 74  GLU n 
1 75  GLU n 
1 76  LEU n 
1 77  ILE n 
1 78  ARG n 
1 79  ARG n 
1 80  ILE n 
1 81  PRO n 
1 82  PHE n 
1 83  SER n 
1 84  GLU n 
1 85  GLU n 
1 86  ILE n 
1 87  ARG n 
1 88  ARG n 
1 89  GLU n 
1 90  LEU n 
1 91  GLU n 
1 92  GLU n 
1 93  ILE n 
1 94  LEU n 
1 95  ARG n 
1 96  ARG n 
1 97  LEU n 
1 98  LYS n 
1 99  GLU n 
1 100 LEU n 
1 101 TYR n 
1 102 GLU n 
1 103 GLU n 
1 104 ALA n 
1 105 LYS n 
1 106 ARG n 
1 107 LEU n 
1 108 MET n 
1 109 GLU n 
1 110 LYS n 
1 111 ALA n 
1 112 LYS n 
1 113 GLU n 
1 114 LEU n 
1 115 THR n 
1 116 LYS n 
1 117 ARG n 
1 118 ILE n 
1 119 LYS n 
1 120 LYS n 
1 121 ILE n 
1 122 ASP n 
1 123 THR n 
1 124 THR n 
1 125 ASP n 
1 126 GLU n 
1 127 LYS n 
1 128 THR n 
1 129 LEU n 
1 130 ARG n 
1 131 GLU n 
1 132 TRP n 
1 133 TYR n 
1 134 GLU n 
1 135 ILE n 
1 136 VAL n 
1 137 ARG n 
1 138 GLU n 
1 139 LEU n 
1 140 LEU n 
1 141 GLU n 
1 142 ARG n 
1 143 ALA n 
1 144 LYS n 
1 145 GLU n 
1 146 ILE n 
1 147 ILE n 
1 148 GLU n 
1 149 GLU n 
1 150 ILE n 
1 151 GLU n 
1 152 ARG n 
1 153 LEU n 
1 154 LEU n 
1 155 ARG n 
1 156 ARG n 
1 157 LEU n 
1 158 LEU n 
1 159 GLU n 
1 160 ILE n 
1 161 LEU n 
1 162 GLY n 
1 163 LEU n 
1 164 GLU n 
1 165 HIS n 
1 166 HIS n 
1 167 HIS n 
1 168 HIS n 
1 169 HIS n 
1 170 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   170 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'artificial sequences' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     81077 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                         ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                        ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                      ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                 ? 
'C4 H7 N O4'     133.103 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                 ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                         ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                       ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                           ? 'H2 O' 
18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                      ? 
'C6 H13 N O2'    131.173 
KY6 non-polymer         . '4-[(Z)-1-cyano-2-{6-[(2-hydroxyethyl)(methyl)amino]-1-benzothiophen-2-yl}ethenyl]benzonitrile' ? 
'C21 H17 N3 O S' 359.444 
LEU 'L-peptide linking' y LEUCINE                                                                                         ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                          ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                      ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                   ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                         ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                          ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                       ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                      ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                        ? 
'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                                                          ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   0   0   MET MET A . n 
A 1 2   ASP 2   1   1   ASP ASP A . n 
A 1 3   GLU 3   2   2   GLU GLU A . n 
A 1 4   GLU 4   3   3   GLU GLU A . n 
A 1 5   ARG 5   4   4   ARG ARG A . n 
A 1 6   LEU 6   5   5   LEU LEU A . n 
A 1 7   LYS 7   6   6   LYS LYS A . n 
A 1 8   GLU 8   7   7   GLU GLU A . n 
A 1 9   ILE 9   8   8   ILE ILE A . n 
A 1 10  LEU 10  9   9   LEU LEU A . n 
A 1 11  GLU 11  10  10  GLU GLU A . n 
A 1 12  GLU 12  11  11  GLU GLU A . n 
A 1 13  LEU 13  12  12  LEU LEU A . n 
A 1 14  GLU 14  13  13  GLU GLU A . n 
A 1 15  ARG 15  14  14  ARG ARG A . n 
A 1 16  ILE 16  15  15  ILE ILE A . n 
A 1 17  ILE 17  16  16  ILE ILE A . n 
A 1 18  GLU 18  17  17  GLU GLU A . n 
A 1 19  GLU 19  18  18  GLU GLU A . n 
A 1 20  VAL 20  19  19  VAL VAL A . n 
A 1 21  LYS 21  20  20  LYS LYS A . n 
A 1 22  ARG 22  21  21  ARG ARG A . n 
A 1 23  LEU 23  22  22  LEU LEU A . n 
A 1 24  LEU 24  23  23  LEU LEU A . n 
A 1 25  GLU 25  24  24  GLU GLU A . n 
A 1 26  LYS 26  25  25  LYS LYS A . n 
A 1 27  ASP 27  26  26  ASP ASP A . n 
A 1 28  GLU 28  27  27  GLU GLU A . n 
A 1 29  ARG 29  28  28  ARG ARG A . n 
A 1 30  LEU 30  29  29  LEU LEU A . n 
A 1 31  LEU 31  30  30  LEU LEU A . n 
A 1 32  ARG 32  31  31  ARG ARG A . n 
A 1 33  GLU 33  32  32  GLU GLU A . n 
A 1 34  PHE 34  33  33  PHE PHE A . n 
A 1 35  TYR 35  34  34  TYR TYR A . n 
A 1 36  ARG 36  35  35  ARG ARG A . n 
A 1 37  ARG 37  36  36  ARG ARG A . n 
A 1 38  ASN 38  37  ?   ?   ?   A . n 
A 1 39  VAL 39  38  ?   ?   ?   A . n 
A 1 40  THR 40  39  ?   ?   ?   A . n 
A 1 41  ASP 41  40  40  ASP ASP A . n 
A 1 42  LYS 42  41  41  LYS LYS A . n 
A 1 43  GLU 43  42  42  GLU GLU A . n 
A 1 44  GLU 44  43  43  GLU GLU A . n 
A 1 45  PHE 45  44  44  PHE PHE A . n 
A 1 46  ARG 46  45  45  ARG ARG A . n 
A 1 47  ARG 47  46  46  ARG ARG A . n 
A 1 48  VAL 48  47  47  VAL VAL A . n 
A 1 49  ILE 49  48  48  ILE ILE A . n 
A 1 50  LYS 50  49  49  LYS LYS A . n 
A 1 51  LEU 51  50  50  LEU LEU A . n 
A 1 52  ASP 52  51  51  ASP ASP A . n 
A 1 53  GLU 53  52  52  GLU GLU A . n 
A 1 54  GLU 54  53  53  GLU GLU A . n 
A 1 55  VAL 55  54  54  VAL VAL A . n 
A 1 56  MET 56  55  55  MET MET A . n 
A 1 57  LYS 57  56  56  LYS LYS A . n 
A 1 58  ARG 58  57  57  ARG ARG A . n 
A 1 59  SER 59  58  58  SER SER A . n 
A 1 60  GLU 60  59  59  GLU GLU A . n 
A 1 61  GLU 61  60  60  GLU GLU A . n 
A 1 62  LEU 62  61  61  LEU LEU A . n 
A 1 63  LEU 63  62  62  LEU LEU A . n 
A 1 64  LYS 64  63  63  LYS LYS A . n 
A 1 65  ARG 65  64  64  ARG ARG A . n 
A 1 66  ALA 66  65  65  ALA ALA A . n 
A 1 67  GLU 67  66  66  GLU GLU A . n 
A 1 68  GLU 68  67  67  GLU GLU A . n 
A 1 69  LEU 69  68  68  LEU LEU A . n 
A 1 70  LEU 70  69  69  LEU LEU A . n 
A 1 71  ARG 71  70  70  ARG ARG A . n 
A 1 72  GLU 72  71  71  GLU GLU A . n 
A 1 73  LEU 73  72  72  LEU LEU A . n 
A 1 74  GLU 74  73  73  GLU GLU A . n 
A 1 75  GLU 75  74  74  GLU GLU A . n 
A 1 76  LEU 76  75  75  LEU LEU A . n 
A 1 77  ILE 77  76  76  ILE ILE A . n 
A 1 78  ARG 78  77  77  ARG ARG A . n 
A 1 79  ARG 79  78  78  ARG ARG A . n 
A 1 80  ILE 80  79  79  ILE ILE A . n 
A 1 81  PRO 81  80  80  PRO PRO A . n 
A 1 82  PHE 82  81  81  PHE PHE A . n 
A 1 83  SER 83  82  82  SER SER A . n 
A 1 84  GLU 84  83  83  GLU GLU A . n 
A 1 85  GLU 85  84  84  GLU GLU A . n 
A 1 86  ILE 86  85  85  ILE ILE A . n 
A 1 87  ARG 87  86  86  ARG ARG A . n 
A 1 88  ARG 88  87  87  ARG ARG A . n 
A 1 89  GLU 89  88  88  GLU GLU A . n 
A 1 90  LEU 90  89  89  LEU LEU A . n 
A 1 91  GLU 91  90  90  GLU GLU A . n 
A 1 92  GLU 92  91  91  GLU GLU A . n 
A 1 93  ILE 93  92  92  ILE ILE A . n 
A 1 94  LEU 94  93  93  LEU LEU A . n 
A 1 95  ARG 95  94  94  ARG ARG A . n 
A 1 96  ARG 96  95  95  ARG ARG A . n 
A 1 97  LEU 97  96  96  LEU LEU A . n 
A 1 98  LYS 98  97  97  LYS LYS A . n 
A 1 99  GLU 99  98  98  GLU GLU A . n 
A 1 100 LEU 100 99  99  LEU LEU A . n 
A 1 101 TYR 101 100 100 TYR TYR A . n 
A 1 102 GLU 102 101 101 GLU GLU A . n 
A 1 103 GLU 103 102 102 GLU GLU A . n 
A 1 104 ALA 104 103 103 ALA ALA A . n 
A 1 105 LYS 105 104 104 LYS LYS A . n 
A 1 106 ARG 106 105 105 ARG ARG A . n 
A 1 107 LEU 107 106 106 LEU LEU A . n 
A 1 108 MET 108 107 107 MET MET A . n 
A 1 109 GLU 109 108 108 GLU GLU A . n 
A 1 110 LYS 110 109 109 LYS LYS A . n 
A 1 111 ALA 111 110 110 ALA ALA A . n 
A 1 112 LYS 112 111 111 LYS LYS A . n 
A 1 113 GLU 113 112 112 GLU GLU A . n 
A 1 114 LEU 114 113 113 LEU LEU A . n 
A 1 115 THR 115 114 114 THR THR A . n 
A 1 116 LYS 116 115 115 LYS LYS A . n 
A 1 117 ARG 117 116 116 ARG ARG A . n 
A 1 118 ILE 118 117 117 ILE ILE A . n 
A 1 119 LYS 119 118 118 LYS LYS A . n 
A 1 120 LYS 120 119 119 LYS LYS A . n 
A 1 121 ILE 121 120 120 ILE ILE A . n 
A 1 122 ASP 122 121 121 ASP ASP A . n 
A 1 123 THR 123 122 ?   ?   ?   A . n 
A 1 124 THR 124 123 ?   ?   ?   A . n 
A 1 125 ASP 125 124 124 ASP ASP A . n 
A 1 126 GLU 126 125 125 GLU GLU A . n 
A 1 127 LYS 127 126 126 LYS LYS A . n 
A 1 128 THR 128 127 127 THR THR A . n 
A 1 129 LEU 129 128 128 LEU LEU A . n 
A 1 130 ARG 130 129 129 ARG ARG A . n 
A 1 131 GLU 131 130 130 GLU GLU A . n 
A 1 132 TRP 132 131 131 TRP TRP A . n 
A 1 133 TYR 133 132 132 TYR TYR A . n 
A 1 134 GLU 134 133 133 GLU GLU A . n 
A 1 135 ILE 135 134 134 ILE ILE A . n 
A 1 136 VAL 136 135 135 VAL VAL A . n 
A 1 137 ARG 137 136 136 ARG ARG A . n 
A 1 138 GLU 138 137 137 GLU GLU A . n 
A 1 139 LEU 139 138 138 LEU LEU A . n 
A 1 140 LEU 140 139 139 LEU LEU A . n 
A 1 141 GLU 141 140 140 GLU GLU A . n 
A 1 142 ARG 142 141 141 ARG ARG A . n 
A 1 143 ALA 143 142 142 ALA ALA A . n 
A 1 144 LYS 144 143 143 LYS LYS A . n 
A 1 145 GLU 145 144 144 GLU GLU A . n 
A 1 146 ILE 146 145 145 ILE ILE A . n 
A 1 147 ILE 147 146 146 ILE ILE A . n 
A 1 148 GLU 148 147 147 GLU GLU A . n 
A 1 149 GLU 149 148 148 GLU GLU A . n 
A 1 150 ILE 150 149 149 ILE ILE A . n 
A 1 151 GLU 151 150 150 GLU GLU A . n 
A 1 152 ARG 152 151 151 ARG ARG A . n 
A 1 153 LEU 153 152 152 LEU LEU A . n 
A 1 154 LEU 154 153 153 LEU LEU A . n 
A 1 155 ARG 155 154 154 ARG ARG A . n 
A 1 156 ARG 156 155 155 ARG ARG A . n 
A 1 157 LEU 157 156 156 LEU LEU A . n 
A 1 158 LEU 158 157 157 LEU LEU A . n 
A 1 159 GLU 159 158 158 GLU GLU A . n 
A 1 160 ILE 160 159 159 ILE ILE A . n 
A 1 161 LEU 161 160 160 LEU LEU A . n 
A 1 162 GLY 162 161 161 GLY GLY A . n 
A 1 163 LEU 163 162 162 LEU LEU A . n 
A 1 164 GLU 164 163 163 GLU GLU A . n 
A 1 165 HIS 165 164 ?   ?   ?   A . n 
A 1 166 HIS 166 165 ?   ?   ?   A . n 
A 1 167 HIS 167 166 ?   ?   ?   A . n 
A 1 168 HIS 168 167 ?   ?   ?   A . n 
A 1 169 HIS 169 168 ?   ?   ?   A . n 
A 1 170 HIS 170 169 ?   ?   ?   A . n 
B 1 1   MET 1   0   0   MET MET B . n 
B 1 2   ASP 2   1   1   ASP ASP B . n 
B 1 3   GLU 3   2   2   GLU GLU B . n 
B 1 4   GLU 4   3   3   GLU GLU B . n 
B 1 5   ARG 5   4   4   ARG ARG B . n 
B 1 6   LEU 6   5   5   LEU LEU B . n 
B 1 7   LYS 7   6   6   LYS LYS B . n 
B 1 8   GLU 8   7   7   GLU GLU B . n 
B 1 9   ILE 9   8   8   ILE ILE B . n 
B 1 10  LEU 10  9   9   LEU LEU B . n 
B 1 11  GLU 11  10  10  GLU GLU B . n 
B 1 12  GLU 12  11  11  GLU GLU B . n 
B 1 13  LEU 13  12  12  LEU LEU B . n 
B 1 14  GLU 14  13  13  GLU GLU B . n 
B 1 15  ARG 15  14  14  ARG ARG B . n 
B 1 16  ILE 16  15  15  ILE ILE B . n 
B 1 17  ILE 17  16  16  ILE ILE B . n 
B 1 18  GLU 18  17  17  GLU GLU B . n 
B 1 19  GLU 19  18  18  GLU GLU B . n 
B 1 20  VAL 20  19  19  VAL VAL B . n 
B 1 21  LYS 21  20  20  LYS LYS B . n 
B 1 22  ARG 22  21  21  ARG ARG B . n 
B 1 23  LEU 23  22  22  LEU LEU B . n 
B 1 24  LEU 24  23  23  LEU LEU B . n 
B 1 25  GLU 25  24  24  GLU GLU B . n 
B 1 26  LYS 26  25  25  LYS LYS B . n 
B 1 27  ASP 27  26  26  ASP ASP B . n 
B 1 28  GLU 28  27  27  GLU GLU B . n 
B 1 29  ARG 29  28  28  ARG ARG B . n 
B 1 30  LEU 30  29  29  LEU LEU B . n 
B 1 31  LEU 31  30  30  LEU LEU B . n 
B 1 32  ARG 32  31  31  ARG ARG B . n 
B 1 33  GLU 33  32  32  GLU GLU B . n 
B 1 34  PHE 34  33  33  PHE PHE B . n 
B 1 35  TYR 35  34  34  TYR TYR B . n 
B 1 36  ARG 36  35  35  ARG ARG B . n 
B 1 37  ARG 37  36  36  ARG ARG B . n 
B 1 38  ASN 38  37  ?   ?   ?   B . n 
B 1 39  VAL 39  38  ?   ?   ?   B . n 
B 1 40  THR 40  39  ?   ?   ?   B . n 
B 1 41  ASP 41  40  40  ASP ASP B . n 
B 1 42  LYS 42  41  41  LYS LYS B . n 
B 1 43  GLU 43  42  42  GLU GLU B . n 
B 1 44  GLU 44  43  43  GLU GLU B . n 
B 1 45  PHE 45  44  44  PHE PHE B . n 
B 1 46  ARG 46  45  45  ARG ARG B . n 
B 1 47  ARG 47  46  46  ARG ARG B . n 
B 1 48  VAL 48  47  47  VAL VAL B . n 
B 1 49  ILE 49  48  48  ILE ILE B . n 
B 1 50  LYS 50  49  49  LYS LYS B . n 
B 1 51  LEU 51  50  50  LEU LEU B . n 
B 1 52  ASP 52  51  51  ASP ASP B . n 
B 1 53  GLU 53  52  52  GLU GLU B . n 
B 1 54  GLU 54  53  53  GLU GLU B . n 
B 1 55  VAL 55  54  54  VAL VAL B . n 
B 1 56  MET 56  55  55  MET MET B . n 
B 1 57  LYS 57  56  56  LYS LYS B . n 
B 1 58  ARG 58  57  57  ARG ARG B . n 
B 1 59  SER 59  58  58  SER SER B . n 
B 1 60  GLU 60  59  59  GLU GLU B . n 
B 1 61  GLU 61  60  60  GLU GLU B . n 
B 1 62  LEU 62  61  61  LEU LEU B . n 
B 1 63  LEU 63  62  62  LEU LEU B . n 
B 1 64  LYS 64  63  63  LYS LYS B . n 
B 1 65  ARG 65  64  64  ARG ARG B . n 
B 1 66  ALA 66  65  65  ALA ALA B . n 
B 1 67  GLU 67  66  66  GLU GLU B . n 
B 1 68  GLU 68  67  67  GLU GLU B . n 
B 1 69  LEU 69  68  68  LEU LEU B . n 
B 1 70  LEU 70  69  69  LEU LEU B . n 
B 1 71  ARG 71  70  70  ARG ARG B . n 
B 1 72  GLU 72  71  71  GLU GLU B . n 
B 1 73  LEU 73  72  72  LEU LEU B . n 
B 1 74  GLU 74  73  73  GLU GLU B . n 
B 1 75  GLU 75  74  74  GLU GLU B . n 
B 1 76  LEU 76  75  75  LEU LEU B . n 
B 1 77  ILE 77  76  76  ILE ILE B . n 
B 1 78  ARG 78  77  77  ARG ARG B . n 
B 1 79  ARG 79  78  78  ARG ARG B . n 
B 1 80  ILE 80  79  79  ILE ILE B . n 
B 1 81  PRO 81  80  80  PRO PRO B . n 
B 1 82  PHE 82  81  81  PHE PHE B . n 
B 1 83  SER 83  82  82  SER SER B . n 
B 1 84  GLU 84  83  83  GLU GLU B . n 
B 1 85  GLU 85  84  84  GLU GLU B . n 
B 1 86  ILE 86  85  85  ILE ILE B . n 
B 1 87  ARG 87  86  86  ARG ARG B . n 
B 1 88  ARG 88  87  87  ARG ARG B . n 
B 1 89  GLU 89  88  88  GLU GLU B . n 
B 1 90  LEU 90  89  89  LEU LEU B . n 
B 1 91  GLU 91  90  90  GLU GLU B . n 
B 1 92  GLU 92  91  91  GLU GLU B . n 
B 1 93  ILE 93  92  92  ILE ILE B . n 
B 1 94  LEU 94  93  93  LEU LEU B . n 
B 1 95  ARG 95  94  94  ARG ARG B . n 
B 1 96  ARG 96  95  95  ARG ARG B . n 
B 1 97  LEU 97  96  96  LEU LEU B . n 
B 1 98  LYS 98  97  97  LYS LYS B . n 
B 1 99  GLU 99  98  98  GLU GLU B . n 
B 1 100 LEU 100 99  99  LEU LEU B . n 
B 1 101 TYR 101 100 100 TYR TYR B . n 
B 1 102 GLU 102 101 101 GLU GLU B . n 
B 1 103 GLU 103 102 102 GLU GLU B . n 
B 1 104 ALA 104 103 103 ALA ALA B . n 
B 1 105 LYS 105 104 104 LYS LYS B . n 
B 1 106 ARG 106 105 105 ARG ARG B . n 
B 1 107 LEU 107 106 106 LEU LEU B . n 
B 1 108 MET 108 107 107 MET MET B . n 
B 1 109 GLU 109 108 108 GLU GLU B . n 
B 1 110 LYS 110 109 109 LYS LYS B . n 
B 1 111 ALA 111 110 110 ALA ALA B . n 
B 1 112 LYS 112 111 111 LYS LYS B . n 
B 1 113 GLU 113 112 112 GLU GLU B . n 
B 1 114 LEU 114 113 113 LEU LEU B . n 
B 1 115 THR 115 114 114 THR THR B . n 
B 1 116 LYS 116 115 115 LYS LYS B . n 
B 1 117 ARG 117 116 116 ARG ARG B . n 
B 1 118 ILE 118 117 117 ILE ILE B . n 
B 1 119 LYS 119 118 118 LYS LYS B . n 
B 1 120 LYS 120 119 119 LYS LYS B . n 
B 1 121 ILE 121 120 120 ILE ILE B . n 
B 1 122 ASP 122 121 121 ASP ASP B . n 
B 1 123 THR 123 122 122 THR THR B . n 
B 1 124 THR 124 123 123 THR THR B . n 
B 1 125 ASP 125 124 124 ASP ASP B . n 
B 1 126 GLU 126 125 125 GLU GLU B . n 
B 1 127 LYS 127 126 126 LYS LYS B . n 
B 1 128 THR 128 127 127 THR THR B . n 
B 1 129 LEU 129 128 128 LEU LEU B . n 
B 1 130 ARG 130 129 129 ARG ARG B . n 
B 1 131 GLU 131 130 130 GLU GLU B . n 
B 1 132 TRP 132 131 131 TRP TRP B . n 
B 1 133 TYR 133 132 132 TYR TYR B . n 
B 1 134 GLU 134 133 133 GLU GLU B . n 
B 1 135 ILE 135 134 134 ILE ILE B . n 
B 1 136 VAL 136 135 135 VAL VAL B . n 
B 1 137 ARG 137 136 136 ARG ARG B . n 
B 1 138 GLU 138 137 137 GLU GLU B . n 
B 1 139 LEU 139 138 138 LEU LEU B . n 
B 1 140 LEU 140 139 139 LEU LEU B . n 
B 1 141 GLU 141 140 140 GLU GLU B . n 
B 1 142 ARG 142 141 141 ARG ARG B . n 
B 1 143 ALA 143 142 142 ALA ALA B . n 
B 1 144 LYS 144 143 143 LYS LYS B . n 
B 1 145 GLU 145 144 144 GLU GLU B . n 
B 1 146 ILE 146 145 145 ILE ILE B . n 
B 1 147 ILE 147 146 146 ILE ILE B . n 
B 1 148 GLU 148 147 147 GLU GLU B . n 
B 1 149 GLU 149 148 148 GLU GLU B . n 
B 1 150 ILE 150 149 149 ILE ILE B . n 
B 1 151 GLU 151 150 150 GLU GLU B . n 
B 1 152 ARG 152 151 151 ARG ARG B . n 
B 1 153 LEU 153 152 152 LEU LEU B . n 
B 1 154 LEU 154 153 153 LEU LEU B . n 
B 1 155 ARG 155 154 154 ARG ARG B . n 
B 1 156 ARG 156 155 155 ARG ARG B . n 
B 1 157 LEU 157 156 156 LEU LEU B . n 
B 1 158 LEU 158 157 157 LEU LEU B . n 
B 1 159 GLU 159 158 158 GLU GLU B . n 
B 1 160 ILE 160 159 159 ILE ILE B . n 
B 1 161 LEU 161 160 160 LEU LEU B . n 
B 1 162 GLY 162 161 161 GLY GLY B . n 
B 1 163 LEU 163 162 162 LEU LEU B . n 
B 1 164 GLU 164 163 163 GLU GLU B . n 
B 1 165 HIS 165 164 ?   ?   ?   B . n 
B 1 166 HIS 166 165 ?   ?   ?   B . n 
B 1 167 HIS 167 166 ?   ?   ?   B . n 
B 1 168 HIS 168 167 ?   ?   ?   B . n 
B 1 169 HIS 169 168 ?   ?   ?   B . n 
B 1 170 HIS 170 169 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        KY6 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   KY6 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 KY6 1  201 201 KY6 LIG A . 
D 2 KY6 1  201 201 KY6 LIG B . 
E 3 HOH 1  301 2   HOH HOH A . 
E 3 HOH 2  302 17  HOH HOH A . 
E 3 HOH 3  303 16  HOH HOH A . 
E 3 HOH 4  304 23  HOH HOH A . 
E 3 HOH 5  305 20  HOH HOH A . 
E 3 HOH 6  306 4   HOH HOH A . 
E 3 HOH 7  307 24  HOH HOH A . 
E 3 HOH 8  308 18  HOH HOH A . 
E 3 HOH 9  309 6   HOH HOH A . 
E 3 HOH 10 310 30  HOH HOH A . 
E 3 HOH 11 311 25  HOH HOH A . 
E 3 HOH 12 312 9   HOH HOH A . 
E 3 HOH 13 313 26  HOH HOH A . 
E 3 HOH 14 314 3   HOH HOH A . 
E 3 HOH 15 315 1   HOH HOH A . 
E 3 HOH 16 316 5   HOH HOH A . 
E 3 HOH 17 317 19  HOH HOH A . 
E 3 HOH 18 318 10  HOH HOH A . 
E 3 HOH 19 319 11  HOH HOH A . 
E 3 HOH 20 320 22  HOH HOH A . 
E 3 HOH 21 321 21  HOH HOH A . 
E 3 HOH 22 322 15  HOH HOH A . 
F 3 HOH 1  301 14  HOH HOH B . 
F 3 HOH 2  302 27  HOH HOH B . 
F 3 HOH 3  303 28  HOH HOH B . 
F 3 HOH 4  304 29  HOH HOH B . 
F 3 HOH 5  305 8   HOH HOH B . 
F 3 HOH 6  306 7   HOH HOH B . 
F 3 HOH 7  307 31  HOH HOH B . 
F 3 HOH 8  308 12  HOH HOH B . 
F 3 HOH 9  309 13  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A PHE 33  ? CG  ? A PHE 34  CG  
2  1 Y 1 A PHE 33  ? CD1 ? A PHE 34  CD1 
3  1 Y 1 A PHE 33  ? CD2 ? A PHE 34  CD2 
4  1 Y 1 A PHE 33  ? CE1 ? A PHE 34  CE1 
5  1 Y 1 A PHE 33  ? CE2 ? A PHE 34  CE2 
6  1 Y 1 A PHE 33  ? CZ  ? A PHE 34  CZ  
7  1 Y 1 A ASP 40  ? CG  ? A ASP 41  CG  
8  1 Y 1 A ASP 40  ? OD1 ? A ASP 41  OD1 
9  1 Y 1 A ASP 40  ? OD2 ? A ASP 41  OD2 
10 1 Y 1 A PHE 44  ? CG  ? A PHE 45  CG  
11 1 Y 1 A PHE 44  ? CD1 ? A PHE 45  CD1 
12 1 Y 1 A PHE 44  ? CD2 ? A PHE 45  CD2 
13 1 Y 1 A PHE 44  ? CE1 ? A PHE 45  CE1 
14 1 Y 1 A PHE 44  ? CE2 ? A PHE 45  CE2 
15 1 Y 1 A PHE 44  ? CZ  ? A PHE 45  CZ  
16 1 Y 1 A ARG 46  ? CG  ? A ARG 47  CG  
17 1 Y 1 A ARG 46  ? CD  ? A ARG 47  CD  
18 1 Y 1 A ARG 46  ? NE  ? A ARG 47  NE  
19 1 Y 1 A ARG 46  ? CZ  ? A ARG 47  CZ  
20 1 Y 1 A ARG 46  ? NH1 ? A ARG 47  NH1 
21 1 Y 1 A ARG 46  ? NH2 ? A ARG 47  NH2 
22 1 Y 1 A LYS 56  ? CG  ? A LYS 57  CG  
23 1 Y 1 A LYS 56  ? CD  ? A LYS 57  CD  
24 1 Y 1 A LYS 56  ? CE  ? A LYS 57  CE  
25 1 Y 1 A LYS 56  ? NZ  ? A LYS 57  NZ  
26 1 Y 1 A ARG 57  ? CG  ? A ARG 58  CG  
27 1 Y 1 A ARG 57  ? CD  ? A ARG 58  CD  
28 1 Y 1 A ARG 57  ? NE  ? A ARG 58  NE  
29 1 Y 1 A ARG 57  ? CZ  ? A ARG 58  CZ  
30 1 Y 1 A ARG 57  ? NH1 ? A ARG 58  NH1 
31 1 Y 1 A ARG 57  ? NH2 ? A ARG 58  NH2 
32 1 Y 1 A GLU 84  ? CG  ? A GLU 85  CG  
33 1 Y 1 A GLU 84  ? CD  ? A GLU 85  CD  
34 1 Y 1 A GLU 84  ? OE1 ? A GLU 85  OE1 
35 1 Y 1 A GLU 84  ? OE2 ? A GLU 85  OE2 
36 1 Y 1 A ARG 129 ? CG  ? A ARG 130 CG  
37 1 Y 1 A ARG 129 ? CD  ? A ARG 130 CD  
38 1 Y 1 A ARG 129 ? NE  ? A ARG 130 NE  
39 1 Y 1 A ARG 129 ? CZ  ? A ARG 130 CZ  
40 1 Y 1 A ARG 129 ? NH1 ? A ARG 130 NH1 
41 1 Y 1 A ARG 129 ? NH2 ? A ARG 130 NH2 
42 1 Y 1 B ARG 21  ? CG  ? B ARG 22  CG  
43 1 Y 1 B ARG 21  ? CD  ? B ARG 22  CD  
44 1 Y 1 B ARG 21  ? NE  ? B ARG 22  NE  
45 1 Y 1 B ARG 21  ? CZ  ? B ARG 22  CZ  
46 1 Y 1 B ARG 21  ? NH1 ? B ARG 22  NH1 
47 1 Y 1 B ARG 21  ? NH2 ? B ARG 22  NH2 
48 1 Y 1 B ARG 31  ? CG  ? B ARG 32  CG  
49 1 Y 1 B ARG 31  ? CD  ? B ARG 32  CD  
50 1 Y 1 B ARG 31  ? NE  ? B ARG 32  NE  
51 1 Y 1 B ARG 31  ? CZ  ? B ARG 32  CZ  
52 1 Y 1 B ARG 31  ? NH1 ? B ARG 32  NH1 
53 1 Y 1 B ARG 31  ? NH2 ? B ARG 32  NH2 
54 1 Y 1 B PHE 33  ? CG  ? B PHE 34  CG  
55 1 Y 1 B PHE 33  ? CD1 ? B PHE 34  CD1 
56 1 Y 1 B PHE 33  ? CD2 ? B PHE 34  CD2 
57 1 Y 1 B PHE 33  ? CE1 ? B PHE 34  CE1 
58 1 Y 1 B PHE 33  ? CE2 ? B PHE 34  CE2 
59 1 Y 1 B PHE 33  ? CZ  ? B PHE 34  CZ  
60 1 Y 1 B ARG 45  ? CG  ? B ARG 46  CG  
61 1 Y 1 B ARG 45  ? CD  ? B ARG 46  CD  
62 1 Y 1 B ARG 45  ? NE  ? B ARG 46  NE  
63 1 Y 1 B ARG 45  ? CZ  ? B ARG 46  CZ  
64 1 Y 1 B ARG 45  ? NH1 ? B ARG 46  NH1 
65 1 Y 1 B ARG 45  ? NH2 ? B ARG 46  NH2 
66 1 Y 1 B LYS 63  ? CG  ? B LYS 64  CG  
67 1 Y 1 B LYS 63  ? CD  ? B LYS 64  CD  
68 1 Y 1 B LYS 63  ? CE  ? B LYS 64  CE  
69 1 Y 1 B LYS 63  ? NZ  ? B LYS 64  NZ  
70 1 Y 1 B LYS 109 ? CG  ? B LYS 110 CG  
71 1 Y 1 B LYS 109 ? CD  ? B LYS 110 CD  
72 1 Y 1 B LYS 109 ? CE  ? B LYS 110 CE  
73 1 Y 1 B LYS 109 ? NZ  ? B LYS 110 NZ  
74 1 Y 1 B THR 122 ? OG1 ? B THR 123 OG1 
75 1 Y 1 B THR 122 ? CG2 ? B THR 123 CG2 
76 1 Y 1 B THR 123 ? OG1 ? B THR 124 OG1 
77 1 Y 1 B THR 123 ? CG2 ? B THR 124 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.1_4122 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   107.791 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W6E 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     40.557 
_cell.length_a_esd                 ? 
_cell.length_b                     91.912 
_cell.length_b_esd                 ? 
_cell.length_c                     52.198 
_cell.length_c_esd                 ? 
_cell.volume                       185271.992 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W6E 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8W6E 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.01 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.2 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2M Lithium sulfate, 20% W/V PEG1000, 0.1M Sodium phosphate citrate PH4.2' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             100K 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-01-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97918 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97918 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          37.50 
_reflns.entry_id                                       8W6E 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.10 
_reflns.d_resolution_low                               30 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     20877 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                11.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          26.000 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.000 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.10 
_reflns_shell.d_res_low                                     2.14 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.33 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1864 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.5 
_reflns_shell.pdbx_chi_squared                              0.415 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.797 
_reflns_shell.pdbx_CC_star                                  0.942 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          95.1 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.824 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               51.96 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8W6E 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.10 
_refine.ls_d_res_low                             29.57 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20877 
_refine.ls_number_reflns_R_free                  989 
_refine.ls_number_reflns_R_work                  19888 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.61 
_refine.ls_percent_reflns_R_free                 4.74 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2188 
_refine.ls_R_factor_R_free                       0.2441 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2176 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 29.6492 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2630 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.10 
_refine_hist.d_res_low                        29.57 
_refine_hist.number_atoms_solvent             31 
_refine_hist.number_atoms_total               2838 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2755 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         52 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0107  ? 2821 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.4853  ? 3749 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0894  ? 418  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0045  ? 480  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 19.0536 ? 1222 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.10 2.22  . . 125 2629 91.40  . . . . 0.2746 . . . . . . . . . . . 0.3225 
'X-RAY DIFFRACTION' 2.22 2.35  . . 119 2877 99.47  . . . . 0.2439 . . . . . . . . . . . 0.2842 
'X-RAY DIFFRACTION' 2.35 2.54  . . 132 2884 99.93  . . . . 0.2282 . . . . . . . . . . . 0.2398 
'X-RAY DIFFRACTION' 2.54 2.79  . . 176 2841 99.93  . . . . 0.2288 . . . . . . . . . . . 0.2694 
'X-RAY DIFFRACTION' 2.79 3.19  . . 133 2875 99.97  . . . . 0.2200 . . . . . . . . . . . 0.2563 
'X-RAY DIFFRACTION' 3.20 4.02  . . 151 2885 100.00 . . . . 0.1931 . . . . . . . . . . . 0.2177 
'X-RAY DIFFRACTION' 4.02 29.57 . . 153 2897 99.54  . . . . 0.2174 . . . . . . . . . . . 0.2352 
# 
_struct.entry_id                     8W6E 
_struct.title                        'De novo design of HBC599 binder' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W6E 
_struct_keywords.text            'de novo protein design; ligand binding; fluorogenic; fluorescent protein, DE NOVO PROTEIN' 
_struct_keywords.pdbx_keywords   'DE NOVO PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8W6E 
_struct_ref.pdbx_db_accession          8W6E 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8W6E A 1 ? 170 ? 8W6E 0 ? 169 ? 0 169 
2 1 8W6E B 1 ? 170 ? 8W6E 0 ? 169 ? 0 169 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,E 
2 1 B,D,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ASP A 2   ? ARG A 37  ? ASP A 1   ARG A 36  1 ? 36 
HELX_P HELX_P2 AA2 LYS A 42  ? ILE A 80  ? LYS A 41  ILE A 79  1 ? 39 
HELX_P HELX_P3 AA3 SER A 83  ? LYS A 119 ? SER A 82  LYS A 118 1 ? 37 
HELX_P HELX_P4 AA4 GLU A 126 ? GLY A 162 ? GLU A 125 GLY A 161 1 ? 37 
HELX_P HELX_P5 AA5 ASP B 2   ? ARG B 37  ? ASP B 1   ARG B 36  1 ? 36 
HELX_P HELX_P6 AA6 LYS B 42  ? ILE B 80  ? LYS B 41  ILE B 79  1 ? 39 
HELX_P HELX_P7 AA7 SER B 83  ? LYS B 120 ? SER B 82  LYS B 119 1 ? 38 
HELX_P HELX_P8 AA8 ASP B 125 ? LEU B 161 ? ASP B 124 LEU B 160 1 ? 37 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   8W6E 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO B 80  ? ? -65.67  60.69   
2 1 THR B 123 ? ? -120.75 -127.98 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ASN 37  ? A ASN 38  
2  1 Y 1 A VAL 38  ? A VAL 39  
3  1 Y 1 A THR 39  ? A THR 40  
4  1 Y 1 A THR 122 ? A THR 123 
5  1 Y 1 A THR 123 ? A THR 124 
6  1 Y 1 A HIS 164 ? A HIS 165 
7  1 Y 1 A HIS 165 ? A HIS 166 
8  1 Y 1 A HIS 166 ? A HIS 167 
9  1 Y 1 A HIS 167 ? A HIS 168 
10 1 Y 1 A HIS 168 ? A HIS 169 
11 1 Y 1 A HIS 169 ? A HIS 170 
12 1 Y 1 B ASN 37  ? B ASN 38  
13 1 Y 1 B VAL 38  ? B VAL 39  
14 1 Y 1 B THR 39  ? B THR 40  
15 1 Y 1 B HIS 164 ? B HIS 165 
16 1 Y 1 B HIS 165 ? B HIS 166 
17 1 Y 1 B HIS 166 ? B HIS 167 
18 1 Y 1 B HIS 167 ? B HIS 168 
19 1 Y 1 B HIS 168 ? B HIS 169 
20 1 Y 1 B HIS 169 ? B HIS 170 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
GLU N    N N N 74  
GLU CA   C N S 75  
GLU C    C N N 76  
GLU O    O N N 77  
GLU CB   C N N 78  
GLU CG   C N N 79  
GLU CD   C N N 80  
GLU OE1  O N N 81  
GLU OE2  O N N 82  
GLU OXT  O N N 83  
GLU H    H N N 84  
GLU H2   H N N 85  
GLU HA   H N N 86  
GLU HB2  H N N 87  
GLU HB3  H N N 88  
GLU HG2  H N N 89  
GLU HG3  H N N 90  
GLU HE2  H N N 91  
GLU HXT  H N N 92  
GLY N    N N N 93  
GLY CA   C N N 94  
GLY C    C N N 95  
GLY O    O N N 96  
GLY OXT  O N N 97  
GLY H    H N N 98  
GLY H2   H N N 99  
GLY HA2  H N N 100 
GLY HA3  H N N 101 
GLY HXT  H N N 102 
HIS N    N N N 103 
HIS CA   C N S 104 
HIS C    C N N 105 
HIS O    O N N 106 
HIS CB   C N N 107 
HIS CG   C Y N 108 
HIS ND1  N Y N 109 
HIS CD2  C Y N 110 
HIS CE1  C Y N 111 
HIS NE2  N Y N 112 
HIS OXT  O N N 113 
HIS H    H N N 114 
HIS H2   H N N 115 
HIS HA   H N N 116 
HIS HB2  H N N 117 
HIS HB3  H N N 118 
HIS HD1  H N N 119 
HIS HD2  H N N 120 
HIS HE1  H N N 121 
HIS HE2  H N N 122 
HIS HXT  H N N 123 
HOH O    O N N 124 
HOH H1   H N N 125 
HOH H2   H N N 126 
ILE N    N N N 127 
ILE CA   C N S 128 
ILE C    C N N 129 
ILE O    O N N 130 
ILE CB   C N S 131 
ILE CG1  C N N 132 
ILE CG2  C N N 133 
ILE CD1  C N N 134 
ILE OXT  O N N 135 
ILE H    H N N 136 
ILE H2   H N N 137 
ILE HA   H N N 138 
ILE HB   H N N 139 
ILE HG12 H N N 140 
ILE HG13 H N N 141 
ILE HG21 H N N 142 
ILE HG22 H N N 143 
ILE HG23 H N N 144 
ILE HD11 H N N 145 
ILE HD12 H N N 146 
ILE HD13 H N N 147 
ILE HXT  H N N 148 
KY6 C10  C Y N 149 
KY6 C11  C Y N 150 
KY6 C12  C N N 151 
KY6 C13  C N N 152 
KY6 C14  C N N 153 
KY6 C16  C Y N 154 
KY6 C17  C Y N 155 
KY6 C18  C Y N 156 
KY6 C19  C Y N 157 
KY6 C20  C N N 158 
KY6 C01  C N N 159 
KY6 C03  C N N 160 
KY6 C04  C N N 161 
KY6 C06  C Y N 162 
KY6 C07  C Y N 163 
KY6 C08  C Y N 164 
KY6 C09  C Y N 165 
KY6 C22  C Y N 166 
KY6 C23  C Y N 167 
KY6 C25  C Y N 168 
KY6 C26  C Y N 169 
KY6 N02  N N N 170 
KY6 N15  N N N 171 
KY6 N21  N N N 172 
KY6 O05  O N N 173 
KY6 S24  S Y N 174 
KY6 H101 H N N 175 
KY6 H121 H N N 176 
KY6 H171 H N N 177 
KY6 H181 H N N 178 
KY6 H013 H N N 179 
KY6 H012 H N N 180 
KY6 H011 H N N 181 
KY6 H032 H N N 182 
KY6 H031 H N N 183 
KY6 H041 H N N 184 
KY6 H042 H N N 185 
KY6 H071 H N N 186 
KY6 H081 H N N 187 
KY6 H221 H N N 188 
KY6 H231 H N N 189 
KY6 H261 H N N 190 
KY6 H051 H N N 191 
LEU N    N N N 192 
LEU CA   C N S 193 
LEU C    C N N 194 
LEU O    O N N 195 
LEU CB   C N N 196 
LEU CG   C N N 197 
LEU CD1  C N N 198 
LEU CD2  C N N 199 
LEU OXT  O N N 200 
LEU H    H N N 201 
LEU H2   H N N 202 
LEU HA   H N N 203 
LEU HB2  H N N 204 
LEU HB3  H N N 205 
LEU HG   H N N 206 
LEU HD11 H N N 207 
LEU HD12 H N N 208 
LEU HD13 H N N 209 
LEU HD21 H N N 210 
LEU HD22 H N N 211 
LEU HD23 H N N 212 
LEU HXT  H N N 213 
LYS N    N N N 214 
LYS CA   C N S 215 
LYS C    C N N 216 
LYS O    O N N 217 
LYS CB   C N N 218 
LYS CG   C N N 219 
LYS CD   C N N 220 
LYS CE   C N N 221 
LYS NZ   N N N 222 
LYS OXT  O N N 223 
LYS H    H N N 224 
LYS H2   H N N 225 
LYS HA   H N N 226 
LYS HB2  H N N 227 
LYS HB3  H N N 228 
LYS HG2  H N N 229 
LYS HG3  H N N 230 
LYS HD2  H N N 231 
LYS HD3  H N N 232 
LYS HE2  H N N 233 
LYS HE3  H N N 234 
LYS HZ1  H N N 235 
LYS HZ2  H N N 236 
LYS HZ3  H N N 237 
LYS HXT  H N N 238 
MET N    N N N 239 
MET CA   C N S 240 
MET C    C N N 241 
MET O    O N N 242 
MET CB   C N N 243 
MET CG   C N N 244 
MET SD   S N N 245 
MET CE   C N N 246 
MET OXT  O N N 247 
MET H    H N N 248 
MET H2   H N N 249 
MET HA   H N N 250 
MET HB2  H N N 251 
MET HB3  H N N 252 
MET HG2  H N N 253 
MET HG3  H N N 254 
MET HE1  H N N 255 
MET HE2  H N N 256 
MET HE3  H N N 257 
MET HXT  H N N 258 
PHE N    N N N 259 
PHE CA   C N S 260 
PHE C    C N N 261 
PHE O    O N N 262 
PHE CB   C N N 263 
PHE CG   C Y N 264 
PHE CD1  C Y N 265 
PHE CD2  C Y N 266 
PHE CE1  C Y N 267 
PHE CE2  C Y N 268 
PHE CZ   C Y N 269 
PHE OXT  O N N 270 
PHE H    H N N 271 
PHE H2   H N N 272 
PHE HA   H N N 273 
PHE HB2  H N N 274 
PHE HB3  H N N 275 
PHE HD1  H N N 276 
PHE HD2  H N N 277 
PHE HE1  H N N 278 
PHE HE2  H N N 279 
PHE HZ   H N N 280 
PHE HXT  H N N 281 
PRO N    N N N 282 
PRO CA   C N S 283 
PRO C    C N N 284 
PRO O    O N N 285 
PRO CB   C N N 286 
PRO CG   C N N 287 
PRO CD   C N N 288 
PRO OXT  O N N 289 
PRO H    H N N 290 
PRO HA   H N N 291 
PRO HB2  H N N 292 
PRO HB3  H N N 293 
PRO HG2  H N N 294 
PRO HG3  H N N 295 
PRO HD2  H N N 296 
PRO HD3  H N N 297 
PRO HXT  H N N 298 
SER N    N N N 299 
SER CA   C N S 300 
SER C    C N N 301 
SER O    O N N 302 
SER CB   C N N 303 
SER OG   O N N 304 
SER OXT  O N N 305 
SER H    H N N 306 
SER H2   H N N 307 
SER HA   H N N 308 
SER HB2  H N N 309 
SER HB3  H N N 310 
SER HG   H N N 311 
SER HXT  H N N 312 
THR N    N N N 313 
THR CA   C N S 314 
THR C    C N N 315 
THR O    O N N 316 
THR CB   C N R 317 
THR OG1  O N N 318 
THR CG2  C N N 319 
THR OXT  O N N 320 
THR H    H N N 321 
THR H2   H N N 322 
THR HA   H N N 323 
THR HB   H N N 324 
THR HG1  H N N 325 
THR HG21 H N N 326 
THR HG22 H N N 327 
THR HG23 H N N 328 
THR HXT  H N N 329 
TRP N    N N N 330 
TRP CA   C N S 331 
TRP C    C N N 332 
TRP O    O N N 333 
TRP CB   C N N 334 
TRP CG   C Y N 335 
TRP CD1  C Y N 336 
TRP CD2  C Y N 337 
TRP NE1  N Y N 338 
TRP CE2  C Y N 339 
TRP CE3  C Y N 340 
TRP CZ2  C Y N 341 
TRP CZ3  C Y N 342 
TRP CH2  C Y N 343 
TRP OXT  O N N 344 
TRP H    H N N 345 
TRP H2   H N N 346 
TRP HA   H N N 347 
TRP HB2  H N N 348 
TRP HB3  H N N 349 
TRP HD1  H N N 350 
TRP HE1  H N N 351 
TRP HE3  H N N 352 
TRP HZ2  H N N 353 
TRP HZ3  H N N 354 
TRP HH2  H N N 355 
TRP HXT  H N N 356 
TYR N    N N N 357 
TYR CA   C N S 358 
TYR C    C N N 359 
TYR O    O N N 360 
TYR CB   C N N 361 
TYR CG   C Y N 362 
TYR CD1  C Y N 363 
TYR CD2  C Y N 364 
TYR CE1  C Y N 365 
TYR CE2  C Y N 366 
TYR CZ   C Y N 367 
TYR OH   O N N 368 
TYR OXT  O N N 369 
TYR H    H N N 370 
TYR H2   H N N 371 
TYR HA   H N N 372 
TYR HB2  H N N 373 
TYR HB3  H N N 374 
TYR HD1  H N N 375 
TYR HD2  H N N 376 
TYR HE1  H N N 377 
TYR HE2  H N N 378 
TYR HH   H N N 379 
TYR HXT  H N N 380 
VAL N    N N N 381 
VAL CA   C N S 382 
VAL C    C N N 383 
VAL O    O N N 384 
VAL CB   C N N 385 
VAL CG1  C N N 386 
VAL CG2  C N N 387 
VAL OXT  O N N 388 
VAL H    H N N 389 
VAL H2   H N N 390 
VAL HA   H N N 391 
VAL HB   H N N 392 
VAL HG11 H N N 393 
VAL HG12 H N N 394 
VAL HG13 H N N 395 
VAL HG21 H N N 396 
VAL HG22 H N N 397 
VAL HG23 H N N 398 
VAL HXT  H N N 399 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLU N   CA   sing N N 70  
GLU N   H    sing N N 71  
GLU N   H2   sing N N 72  
GLU CA  C    sing N N 73  
GLU CA  CB   sing N N 74  
GLU CA  HA   sing N N 75  
GLU C   O    doub N N 76  
GLU C   OXT  sing N N 77  
GLU CB  CG   sing N N 78  
GLU CB  HB2  sing N N 79  
GLU CB  HB3  sing N N 80  
GLU CG  CD   sing N N 81  
GLU CG  HG2  sing N N 82  
GLU CG  HG3  sing N N 83  
GLU CD  OE1  doub N N 84  
GLU CD  OE2  sing N N 85  
GLU OE2 HE2  sing N N 86  
GLU OXT HXT  sing N N 87  
GLY N   CA   sing N N 88  
GLY N   H    sing N N 89  
GLY N   H2   sing N N 90  
GLY CA  C    sing N N 91  
GLY CA  HA2  sing N N 92  
GLY CA  HA3  sing N N 93  
GLY C   O    doub N N 94  
GLY C   OXT  sing N N 95  
GLY OXT HXT  sing N N 96  
HIS N   CA   sing N N 97  
HIS N   H    sing N N 98  
HIS N   H2   sing N N 99  
HIS CA  C    sing N N 100 
HIS CA  CB   sing N N 101 
HIS CA  HA   sing N N 102 
HIS C   O    doub N N 103 
HIS C   OXT  sing N N 104 
HIS CB  CG   sing N N 105 
HIS CB  HB2  sing N N 106 
HIS CB  HB3  sing N N 107 
HIS CG  ND1  sing Y N 108 
HIS CG  CD2  doub Y N 109 
HIS ND1 CE1  doub Y N 110 
HIS ND1 HD1  sing N N 111 
HIS CD2 NE2  sing Y N 112 
HIS CD2 HD2  sing N N 113 
HIS CE1 NE2  sing Y N 114 
HIS CE1 HE1  sing N N 115 
HIS NE2 HE2  sing N N 116 
HIS OXT HXT  sing N N 117 
HOH O   H1   sing N N 118 
HOH O   H2   sing N N 119 
ILE N   CA   sing N N 120 
ILE N   H    sing N N 121 
ILE N   H2   sing N N 122 
ILE CA  C    sing N N 123 
ILE CA  CB   sing N N 124 
ILE CA  HA   sing N N 125 
ILE C   O    doub N N 126 
ILE C   OXT  sing N N 127 
ILE CB  CG1  sing N N 128 
ILE CB  CG2  sing N N 129 
ILE CB  HB   sing N N 130 
ILE CG1 CD1  sing N N 131 
ILE CG1 HG12 sing N N 132 
ILE CG1 HG13 sing N N 133 
ILE CG2 HG21 sing N N 134 
ILE CG2 HG22 sing N N 135 
ILE CG2 HG23 sing N N 136 
ILE CD1 HD11 sing N N 137 
ILE CD1 HD12 sing N N 138 
ILE CD1 HD13 sing N N 139 
ILE OXT HXT  sing N N 140 
KY6 C08 C07  doub Y N 141 
KY6 C08 C09  sing Y N 142 
KY6 C07 C06  sing Y N 143 
KY6 C10 C09  sing Y N 144 
KY6 C10 C11  doub Y N 145 
KY6 C09 C25  doub Y N 146 
KY6 C06 N02  sing N N 147 
KY6 C06 C26  doub Y N 148 
KY6 N02 C01  sing N N 149 
KY6 N02 C03  sing N N 150 
KY6 C11 C12  sing N N 151 
KY6 C11 S24  sing Y N 152 
KY6 C12 C13  doub N Z 153 
KY6 C03 C04  sing N N 154 
KY6 C25 C26  sing Y N 155 
KY6 C25 S24  sing Y N 156 
KY6 C17 C18  doub Y N 157 
KY6 C17 C16  sing Y N 158 
KY6 C18 C19  sing Y N 159 
KY6 C16 C13  sing N N 160 
KY6 C16 C23  doub Y N 161 
KY6 C13 C14  sing N N 162 
KY6 C19 C20  sing N N 163 
KY6 C19 C22  doub Y N 164 
KY6 C20 N21  trip N N 165 
KY6 C23 C22  sing Y N 166 
KY6 C04 O05  sing N N 167 
KY6 C14 N15  trip N N 168 
KY6 C10 H101 sing N N 169 
KY6 C12 H121 sing N N 170 
KY6 C17 H171 sing N N 171 
KY6 C18 H181 sing N N 172 
KY6 C01 H013 sing N N 173 
KY6 C01 H012 sing N N 174 
KY6 C01 H011 sing N N 175 
KY6 C03 H032 sing N N 176 
KY6 C03 H031 sing N N 177 
KY6 C04 H041 sing N N 178 
KY6 C04 H042 sing N N 179 
KY6 C07 H071 sing N N 180 
KY6 C08 H081 sing N N 181 
KY6 C22 H221 sing N N 182 
KY6 C23 H231 sing N N 183 
KY6 C26 H261 sing N N 184 
KY6 O05 H051 sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, China)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           2020YFA0909200 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W6E 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.024657 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.007912 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010880 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.020120 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . MET A 1 1   ? -21.55860 27.55198  37.52867  1.000 74.71886  ? 0   MET A N    1 
ATOM   2    C CA   . MET A 1 1   ? -20.35966 28.32630  37.95125  1.000 74.93289  ? 0   MET A CA   1 
ATOM   3    C C    . MET A 1 1   ? -19.97012 29.33019  36.85698  1.000 71.51695  ? 0   MET A C    1 
ATOM   4    O O    . MET A 1 1   ? -20.70838 29.44287  35.86314  1.000 65.07581  ? 0   MET A O    1 
ATOM   5    C CB   . MET A 1 1   ? -19.17639 27.40460  38.25113  1.000 65.17336  ? 0   MET A CB   1 
ATOM   6    C CG   . MET A 1 1   ? -18.63309 27.56195  39.64397  1.000 80.31727  ? 0   MET A CG   1 
ATOM   7    S SD   . MET A 1 1   ? -17.07488 26.67730  39.76975  1.000 102.71711 ? 0   MET A SD   1 
ATOM   8    C CE   . MET A 1 1   ? -17.63759 24.99714  39.51518  1.000 81.16989  ? 0   MET A CE   1 
ATOM   9    N N    . ASP A 1 2   ? -18.84322 30.01646  37.04459  1.000 71.70432  ? 1   ASP A N    1 
ATOM   10   C CA   . ASP A 1 2   ? -18.41967 31.08638  36.10630  1.000 61.26088  ? 1   ASP A CA   1 
ATOM   11   C C    . ASP A 1 2   ? -17.83187 30.54728  34.79826  1.000 69.29193  ? 1   ASP A C    1 
ATOM   12   O O    . ASP A 1 2   ? -17.67065 29.32328  34.64943  1.000 52.50667  ? 1   ASP A O    1 
ATOM   13   C CB   . ASP A 1 2   ? -17.39469 31.99671  36.78090  1.000 61.12182  ? 1   ASP A CB   1 
ATOM   14   C CG   . ASP A 1 2   ? -18.03172 33.07673  37.62587  1.000 76.57314  ? 1   ASP A CG   1 
ATOM   15   O OD1  . ASP A 1 2   ? -18.45806 34.08954  37.04779  1.000 87.02319  ? 1   ASP A OD1  1 
ATOM   16   O OD2  . ASP A 1 2   ? -18.10638 32.88593  38.85192  1.000 93.92993  ? 1   ASP A OD2  1 
ATOM   17   N N    . GLU A 1 3   ? -17.51127 31.46418  33.89302  1.000 64.50417  ? 2   GLU A N    1 
ATOM   18   C CA   . GLU A 1 3   ? -16.87350 31.08309  32.61694  1.000 66.62686  ? 2   GLU A CA   1 
ATOM   19   C C    . GLU A 1 3   ? -15.36642 30.99245  32.84459  1.000 61.52682  ? 2   GLU A C    1 
ATOM   20   O O    . GLU A 1 3   ? -14.67153 30.47944  31.96652  1.000 64.06629  ? 2   GLU A O    1 
ATOM   21   C CB   . GLU A 1 3   ? -17.23596 32.12483  31.55884  1.000 80.27962  ? 2   GLU A CB   1 
ATOM   22   C CG   . GLU A 1 3   ? -17.52916 31.51454  30.19802  1.000 92.43891  ? 2   GLU A CG   1 
ATOM   23   C CD   . GLU A 1 3   ? -18.58651 32.19017  29.34215  1.000 76.88251  ? 2   GLU A CD   1 
ATOM   24   O OE1  . GLU A 1 3   ? -19.46251 32.87108  29.90224  1.000 81.95687  ? 2   GLU A OE1  1 
ATOM   25   O OE2  . GLU A 1 3   ? -18.53576 32.01996  28.11417  1.000 64.37524  ? 2   GLU A OE2  1 
ATOM   26   N N    . GLU A 1 4   ? -14.89026 31.49274  33.97939  1.000 58.04304  ? 3   GLU A N    1 
ATOM   27   C CA   . GLU A 1 4   ? -13.44916 31.41110  34.32406  1.000 64.36540  ? 3   GLU A CA   1 
ATOM   28   C C    . GLU A 1 4   ? -13.08877 29.97724  34.71623  1.000 53.57314  ? 3   GLU A C    1 
ATOM   29   O O    . GLU A 1 4   ? -11.96375 29.57643  34.45003  1.000 56.07990  ? 3   GLU A O    1 
ATOM   30   C CB   . GLU A 1 4   ? -13.12609 32.38336  35.45982  1.000 68.36276  ? 3   GLU A CB   1 
ATOM   31   C CG   . GLU A 1 4   ? -11.66101 32.44874  35.85946  1.000 59.22384  ? 3   GLU A CG   1 
ATOM   32   C CD   . GLU A 1 4   ? -10.67236 32.97776  34.83813  1.000 79.26839  ? 3   GLU A CD   1 
ATOM   33   O OE1  . GLU A 1 4   ? -11.11672 33.56250  33.82613  1.000 92.54913  ? 3   GLU A OE1  1 
ATOM   34   O OE2  . GLU A 1 4   ? -9.45627  32.83006  35.07086  1.000 92.45214  ? 3   GLU A OE2  1 
ATOM   35   N N    . ARG A 1 5   ? -14.01647 29.24016  35.31458  1.000 40.40321  ? 4   ARG A N    1 
ATOM   36   C CA   . ARG A 1 5   ? -13.73211 27.81726  35.60476  1.000 50.00553  ? 4   ARG A CA   1 
ATOM   37   C C    . ARG A 1 5   ? -13.66928 27.07804  34.25987  1.000 34.59125  ? 4   ARG A C    1 
ATOM   38   O O    . ARG A 1 5   ? -12.76715 26.27120  34.10880  1.000 37.98900  ? 4   ARG A O    1 
ATOM   39   C CB   . ARG A 1 5   ? -14.77476 27.24021  36.55711  1.000 54.29555  ? 4   ARG A CB   1 
ATOM   40   C CG   . ARG A 1 5   ? -14.37834 25.91340  37.17524  1.000 62.91985  ? 4   ARG A CG   1 
ATOM   41   C CD   . ARG A 1 5   ? -13.10317 26.02181  37.98192  1.000 68.58250  ? 4   ARG A CD   1 
ATOM   42   N NE   . ARG A 1 5   ? -13.13316 27.10797  38.95374  1.000 76.58734  ? 4   ARG A NE   1 
ATOM   43   C CZ   . ARG A 1 5   ? -13.62185 27.02309  40.18587  1.000 87.97076  ? 4   ARG A CZ   1 
ATOM   44   N NH1  . ARG A 1 5   ? -14.13851 25.89006  40.62819  1.000 70.74644  ? 4   ARG A NH1  1 
ATOM   45   N NH2  . ARG A 1 5   ? -13.59288 28.07623  40.98068  1.000 84.64472  ? 4   ARG A NH2  1 
ATOM   46   N N    . LEU A 1 6   ? -14.58656 27.37869  33.33104  1.000 37.86698  ? 5   LEU A N    1 
ATOM   47   C CA   . LEU A 1 6   ? -14.57977 26.79045  31.96314  1.000 49.90271  ? 5   LEU A CA   1 
ATOM   48   C C    . LEU A 1 6   ? -13.19996 26.99063  31.32478  1.000 43.71887  ? 5   LEU A C    1 
ATOM   49   O O    . LEU A 1 6   ? -12.64788 26.01865  30.81281  1.000 42.63003  ? 5   LEU A O    1 
ATOM   50   C CB   . LEU A 1 6   ? -15.66411 27.47408  31.12728  1.000 42.27307  ? 5   LEU A CB   1 
ATOM   51   C CG   . LEU A 1 6   ? -17.06296 26.86781  31.20472  1.000 58.75150  ? 5   LEU A CG   1 
ATOM   52   C CD1  . LEU A 1 6   ? -17.91734 27.33643  30.04184  1.000 42.13691  ? 5   LEU A CD1  1 
ATOM   53   C CD2  . LEU A 1 6   ? -16.99864 25.34983  31.23797  1.000 67.51804  ? 5   LEU A CD2  1 
ATOM   54   N N    . LYS A 1 7   ? -12.67320 28.21075  31.38444  1.000 46.67793  ? 6   LYS A N    1 
ATOM   55   C CA   . LYS A 1 7   ? -11.35840 28.51491  30.77407  1.000 42.54688  ? 6   LYS A CA   1 
ATOM   56   C C    . LYS A 1 7   ? -10.25907 27.71726  31.47195  1.000 43.77379  ? 6   LYS A C    1 
ATOM   57   O O    . LYS A 1 7   ? -9.46312  27.11830  30.76586  1.000 46.66278  ? 6   LYS A O    1 
ATOM   58   C CB   . LYS A 1 7   ? -11.07069 30.01399  30.86674  1.000 48.27756  ? 6   LYS A CB   1 
ATOM   59   C CG   . LYS A 1 7   ? -10.08105 30.55002  29.84741  1.000 54.47190  ? 6   LYS A CG   1 
ATOM   60   C CD   . LYS A 1 7   ? -10.09638 32.05500  29.75915  1.000 75.40938  ? 6   LYS A CD   1 
ATOM   61   C CE   . LYS A 1 7   ? -8.84765  32.62615  29.12576  1.000 71.27351  ? 6   LYS A CE   1 
ATOM   62   N NZ   . LYS A 1 7   ? -7.86949  33.05553  30.15045  1.000 83.00341  ? 6   LYS A NZ   1 
ATOM   63   N N    . GLU A 1 8   ? -10.24376 27.70750  32.79795  1.000 39.72350  ? 7   GLU A N    1 
ATOM   64   C CA   . GLU A 1 8   ? -9.15644  27.03685  33.54680  1.000 41.35863  ? 7   GLU A CA   1 
ATOM   65   C C    . GLU A 1 8   ? -9.12921  25.54580  33.20806  1.000 25.27663  ? 7   GLU A C    1 
ATOM   66   O O    . GLU A 1 8   ? -8.04615  25.03099  33.03189  1.000 37.90697  ? 7   GLU A O    1 
ATOM   67   C CB   . GLU A 1 8   ? -9.33314  27.30908  35.04080  1.000 47.02783  ? 7   GLU A CB   1 
ATOM   68   C CG   . GLU A 1 8   ? -8.02903  27.59747  35.75444  1.000 74.80954  ? 7   GLU A CG   1 
ATOM   69   C CD   . GLU A 1 8   ? -7.26940  28.81954  35.26704  1.000 81.84734  ? 7   GLU A CD   1 
ATOM   70   O OE1  . GLU A 1 8   ? -7.90867  29.86837  35.04701  1.000 74.88369  ? 7   GLU A OE1  1 
ATOM   71   O OE2  . GLU A 1 8   ? -6.03541  28.71977  35.11777  1.000 92.70502  ? 7   GLU A OE2  1 
ATOM   72   N N    . ILE A 1 9   ? -10.29010 24.91154  33.11744  1.000 35.37819  ? 8   ILE A N    1 
ATOM   73   C CA   . ILE A 1 9   ? -10.38089 23.46446  32.76672  1.000 35.01331  ? 8   ILE A CA   1 
ATOM   74   C C    . ILE A 1 9   ? -9.83018  23.24733  31.35163  1.000 31.38039  ? 8   ILE A C    1 
ATOM   75   O O    . ILE A 1 9   ? -8.97404  22.39148  31.20157  1.000 38.00394  ? 8   ILE A O    1 
ATOM   76   C CB   . ILE A 1 9   ? -11.83674 22.97619  32.93415  1.000 34.74548  ? 8   ILE A CB   1 
ATOM   77   C CG1  . ILE A 1 9   ? -12.25339 22.98036  34.40725  1.000 49.40433  ? 8   ILE A CG1  1 
ATOM   78   C CG2  . ILE A 1 9   ? -12.04561 21.61204  32.29744  1.000 46.48415  ? 8   ILE A CG2  1 
ATOM   79   C CD1  . ILE A 1 9   ? -13.74133 22.93609  34.63161  1.000 43.61458  ? 8   ILE A CD1  1 
ATOM   80   N N    . LEU A 1 10  ? -10.28657 24.03907  30.38560  1.000 27.62973  ? 9   LEU A N    1 
ATOM   81   C CA   . LEU A 1 10  ? -9.85288  23.88891  28.97352  1.000 35.92985  ? 9   LEU A CA   1 
ATOM   82   C C    . LEU A 1 10  ? -8.33895  24.09420  28.85712  1.000 32.72841  ? 9   LEU A C    1 
ATOM   83   O O    . LEU A 1 10  ? -7.72397  23.35220  28.11910  1.000 39.14601  ? 9   LEU A O    1 
ATOM   84   C CB   . LEU A 1 10  ? -10.68228 24.85459  28.12655  1.000 29.15407  ? 9   LEU A CB   1 
ATOM   85   C CG   . LEU A 1 10  ? -12.09726 24.37524  27.80797  1.000 36.30087  ? 9   LEU A CG   1 
ATOM   86   C CD1  . LEU A 1 10  ? -12.95761 25.51298  27.30098  1.000 30.16860  ? 9   LEU A CD1  1 
ATOM   87   C CD2  . LEU A 1 10  ? -12.06426 23.23608  26.80816  1.000 32.68680  ? 9   LEU A CD2  1 
ATOM   88   N N    . GLU A 1 11  ? -7.77894  24.99946  29.65383  1.000 35.75767  ? 10  GLU A N    1 
ATOM   89   C CA   . GLU A 1 11  ? -6.32300  25.26976  29.65044  1.000 32.39086  ? 10  GLU A CA   1 
ATOM   90   C C    . GLU A 1 11  ? -5.54461  24.10403  30.27745  1.000 30.92219  ? 10  GLU A C    1 
ATOM   91   O O    . GLU A 1 11  ? -4.50467  23.75315  29.73127  1.000 39.51027  ? 10  GLU A O    1 
ATOM   92   C CB   . GLU A 1 11  ? -6.06910  26.59294  30.36915  1.000 37.24504  ? 10  GLU A CB   1 
ATOM   93   C CG   . GLU A 1 11  ? -6.57553  27.80170  29.61106  1.000 49.59893  ? 10  GLU A CG   1 
ATOM   94   C CD   . GLU A 1 11  ? -6.39663  29.11687  30.35078  1.000 66.05740  ? 10  GLU A CD   1 
ATOM   95   O OE1  . GLU A 1 11  ? -6.42433  29.10808  31.59479  1.000 59.30062  ? 10  GLU A OE1  1 
ATOM   96   O OE2  . GLU A 1 11  ? -6.23100  30.14678  29.68056  1.000 68.98593  ? 10  GLU A OE2  1 
ATOM   97   N N    . GLU A 1 12  ? -6.02623  23.54412  31.38667  1.000 30.18645  ? 11  GLU A N    1 
ATOM   98   C CA   . GLU A 1 12  ? -5.37683  22.35637  32.01672  1.000 32.31127  ? 11  GLU A CA   1 
ATOM   99   C C    . GLU A 1 12  ? -5.44782  21.15818  31.05195  1.000 24.10356  ? 11  GLU A C    1 
ATOM   100  O O    . GLU A 1 12  ? -4.47668  20.41838  30.99584  1.000 35.31102  ? 11  GLU A O    1 
ATOM   101  C CB   . GLU A 1 12  ? -6.02745  22.02447  33.36293  1.000 29.03855  ? 11  GLU A CB   1 
ATOM   102  C CG   . GLU A 1 12  ? -5.93143  23.13467  34.39772  1.000 39.09557  ? 11  GLU A CG   1 
ATOM   103  C CD   . GLU A 1 12  ? -6.95216  23.14065  35.52696  1.000 61.30221  ? 11  GLU A CD   1 
ATOM   104  O OE1  . GLU A 1 12  ? -8.11714  22.77437  35.29230  1.000 59.23456  ? 11  GLU A OE1  1 
ATOM   105  O OE2  . GLU A 1 12  ? -6.58498  23.53592  36.64180  1.000 68.68519  ? 11  GLU A OE2  1 
ATOM   106  N N    . LEU A 1 13  ? -6.55296  20.99983  30.33024  1.000 27.44583  ? 12  LEU A N    1 
ATOM   107  C CA   . LEU A 1 13  ? -6.68797  19.91463  29.32446  1.000 35.23900  ? 12  LEU A CA   1 
ATOM   108  C C    . LEU A 1 13  ? -5.66128  20.13064  28.20918  1.000 31.85345  ? 12  LEU A C    1 
ATOM   109  O O    . LEU A 1 13  ? -5.04818  19.14770  27.80220  1.000 30.95142  ? 12  LEU A O    1 
ATOM   110  C CB   . LEU A 1 13  ? -8.11610  19.91824  28.78980  1.000 31.71496  ? 12  LEU A CB   1 
ATOM   111  C CG   . LEU A 1 13  ? -9.14975  19.16517  29.62217  1.000 35.25601  ? 12  LEU A CG   1 
ATOM   112  C CD1  . LEU A 1 13  ? -10.55593 19.55881  29.20244  1.000 30.42533  ? 12  LEU A CD1  1 
ATOM   113  C CD2  . LEU A 1 13  ? -8.95947  17.66719  29.49639  1.000 27.86119  ? 12  LEU A CD2  1 
ATOM   114  N N    . GLU A 1 14  ? -5.46764  21.37661  27.77691  1.000 30.72036  ? 13  GLU A N    1 
ATOM   115  C CA   . GLU A 1 14  ? -4.45996  21.72364  26.74161  1.000 39.33996  ? 13  GLU A CA   1 
ATOM   116  C C    . GLU A 1 14  ? -3.05377  21.36701  27.21534  1.000 35.20170  ? 13  GLU A C    1 
ATOM   117  O O    . GLU A 1 14  ? -2.32283  20.74903  26.45827  1.000 39.83016  ? 13  GLU A O    1 
ATOM   118  C CB   . GLU A 1 14  ? -4.57435  23.20656  26.41438  1.000 31.03842  ? 13  GLU A CB   1 
ATOM   119  C CG   . GLU A 1 14  ? -5.81161  23.55716  25.61761  1.000 36.52147  ? 13  GLU A CG   1 
ATOM   120  C CD   . GLU A 1 14  ? -5.92200  25.02808  25.26638  1.000 44.36019  ? 13  GLU A CD   1 
ATOM   121  O OE1  . GLU A 1 14  ? -5.68796  25.86328  26.15718  1.000 46.85866  ? 13  GLU A OE1  1 
ATOM   122  O OE2  . GLU A 1 14  ? -6.24233  25.33081  24.10941  1.000 43.31879  ? 13  GLU A OE2  1 
ATOM   123  N N    . ARG A 1 15  ? -2.71656  21.74429  28.43619  1.000 36.66432  ? 14  ARG A N    1 
ATOM   124  C CA   . ARG A 1 15  ? -1.39036  21.43267  29.00893  1.000 38.47403  ? 14  ARG A CA   1 
ATOM   125  C C    . ARG A 1 15  ? -1.17103  19.91772  29.06814  1.000 28.93246  ? 14  ARG A C    1 
ATOM   126  O O    . ARG A 1 15  ? -0.05001  19.49791  28.79795  1.000 43.48665  ? 14  ARG A O    1 
ATOM   127  C CB   . ARG A 1 15  ? -1.27516  22.07993  30.39279  1.000 37.42432  ? 14  ARG A CB   1 
ATOM   128  C CG   . ARG A 1 15  ? -1.12848  23.59396  30.36349  1.000 57.50861  ? 14  ARG A CG   1 
ATOM   129  C CD   . ARG A 1 15  ? -0.61729  24.16029  31.67227  1.000 53.87006  ? 14  ARG A CD   1 
ATOM   130  N NE   . ARG A 1 15  ? -1.66908  24.27725  32.67450  1.000 60.67743  ? 14  ARG A NE   1 
ATOM   131  C CZ   . ARG A 1 15  ? -2.48126  25.31911  32.81151  1.000 59.88065  ? 14  ARG A CZ   1 
ATOM   132  N NH1  . ARG A 1 15  ? -2.37767  26.35999  32.00631  1.000 61.89862  ? 14  ARG A NH1  1 
ATOM   133  N NH2  . ARG A 1 15  ? -3.40303  25.31508  33.75573  1.000 51.78306  ? 14  ARG A NH2  1 
ATOM   134  N N    . ILE A 1 16  ? -2.20780  19.15157  29.40052  1.000 36.84433  ? 15  ILE A N    1 
ATOM   135  C CA   . ILE A 1 16  ? -2.11047  17.66560  29.46976  1.000 37.90814  ? 15  ILE A CA   1 
ATOM   136  C C    . ILE A 1 16  ? -1.78169  17.11843  28.08478  1.000 22.17528  ? 15  ILE A C    1 
ATOM   137  O O    . ILE A 1 16  ? -0.83555  16.36461  27.99268  1.000 42.66487  ? 15  ILE A O    1 
ATOM   138  C CB   . ILE A 1 16  ? -3.40021  17.04443  30.02517  1.000 40.40227  ? 15  ILE A CB   1 
ATOM   139  C CG1  . ILE A 1 16  ? -3.60293  17.38164  31.50416  1.000 47.36462  ? 15  ILE A CG1  1 
ATOM   140  C CG2  . ILE A 1 16  ? -3.43695  15.54238  29.79445  1.000 35.34067  ? 15  ILE A CG2  1 
ATOM   141  C CD1  . ILE A 1 16  ? -5.01377  17.18844  31.99253  1.000 30.59436  ? 15  ILE A CD1  1 
ATOM   142  N N    . ILE A 1 17  ? -2.55801  17.49309  27.07790  1.000 37.30898  ? 16  ILE A N    1 
ATOM   143  C CA   . ILE A 1 17  ? -2.36123  16.99089  25.68494  1.000 47.24906  ? 16  ILE A CA   1 
ATOM   144  C C    . ILE A 1 17  ? -0.96143  17.36909  25.17954  1.000 45.98351  ? 16  ILE A C    1 
ATOM   145  O O    . ILE A 1 17  ? -0.37643  16.55509  24.47954  1.000 37.40464  ? 16  ILE A O    1 
ATOM   146  C CB   . ILE A 1 17  ? -3.50355  17.47649  24.77012  1.000 43.50401  ? 16  ILE A CB   1 
ATOM   147  C CG1  . ILE A 1 17  ? -3.82660  16.44523  23.68338  1.000 39.97490  ? 16  ILE A CG1  1 
ATOM   148  C CG2  . ILE A 1 17  ? -3.21198  18.84245  24.17682  1.000 35.19542  ? 16  ILE A CG2  1 
ATOM   149  C CD1  . ILE A 1 17  ? -4.15519  15.07626  24.21870  1.000 37.26315  ? 16  ILE A CD1  1 
ATOM   150  N N    . GLU A 1 18  ? -0.44858  18.53326  25.57421  1.000 36.21311  ? 17  GLU A N    1 
ATOM   151  C CA   . GLU A 1 18  ? 0.90122   18.99447  25.14381  1.000 41.25750  ? 17  GLU A CA   1 
ATOM   152  C C    . GLU A 1 18  ? 1.98056   18.14281  25.81870  1.000 32.99819  ? 17  GLU A C    1 
ATOM   153  O O    . GLU A 1 18  ? 2.95947   17.81690  25.15952  1.000 39.28365  ? 17  GLU A O    1 
ATOM   154  C CB   . GLU A 1 18  ? 1.05997   20.49454  25.39651  1.000 41.87669  ? 17  GLU A CB   1 
ATOM   155  C CG   . GLU A 1 18  ? 0.20058   21.35921  24.49656  1.000 37.92406  ? 17  GLU A CG   1 
ATOM   156  C CD   . GLU A 1 18  ? -0.06060  22.77624  24.98238  1.000 65.73272  ? 17  GLU A CD   1 
ATOM   157  O OE1  . GLU A 1 18  ? 0.68152   23.24355  25.87112  1.000 61.38765  ? 17  GLU A OE1  1 
ATOM   158  O OE2  . GLU A 1 18  ? -1.00085  23.41296  24.47149  1.000 62.47609  ? 17  GLU A OE2  1 
ATOM   159  N N    . GLU A 1 19  ? 1.79493   17.80899  27.08780  1.000 45.34804  ? 18  GLU A N    1 
ATOM   160  C CA   . GLU A 1 19  ? 2.74328   16.90731  27.78273  1.000 44.05879  ? 18  GLU A CA   1 
ATOM   161  C C    . GLU A 1 19  ? 2.66642   15.51718  27.15300  1.000 38.88293  ? 18  GLU A C    1 
ATOM   162  O O    . GLU A 1 19  ? 3.71550   14.91937  26.95985  1.000 43.32102  ? 18  GLU A O    1 
ATOM   163  C CB   . GLU A 1 19  ? 2.45465   16.84251  29.28081  1.000 35.49386  ? 18  GLU A CB   1 
ATOM   164  C CG   . GLU A 1 19  ? 3.49900   16.06986  30.06770  1.000 48.02820  ? 18  GLU A CG   1 
ATOM   165  C CD   . GLU A 1 19  ? 4.95186   16.37411  29.73830  1.000 76.12218  ? 18  GLU A CD   1 
ATOM   166  O OE1  . GLU A 1 19  ? 5.33263   17.55719  29.78900  1.000 77.72542  ? 18  GLU A OE1  1 
ATOM   167  O OE2  . GLU A 1 19  ? 5.70098   15.42921  29.44129  1.000 70.91380  ? 18  GLU A OE2  1 
ATOM   168  N N    . VAL A 1 20  ? 1.46045   15.03488  26.86337  1.000 30.37027  ? 19  VAL A N    1 
ATOM   169  C CA   . VAL A 1 20  ? 1.27657   13.70273  26.20964  1.000 40.55834  ? 19  VAL A CA   1 
ATOM   170  C C    . VAL A 1 20  ? 2.02425   13.69365  24.86947  1.000 34.19978  ? 19  VAL A C    1 
ATOM   171  O O    . VAL A 1 20  ? 2.69339   12.70274  24.59748  1.000 36.44728  ? 19  VAL A O    1 
ATOM   172  C CB   . VAL A 1 20  ? -0.21439  13.34840  26.06806  1.000 34.73458  ? 19  VAL A CB   1 
ATOM   173  C CG1  . VAL A 1 20  ? -0.41935  12.12920  25.18032  1.000 39.64902  ? 19  VAL A CG1  1 
ATOM   174  C CG2  . VAL A 1 20  ? -0.86202  13.15050  27.42525  1.000 34.05010  ? 19  VAL A CG2  1 
ATOM   175  N N    . LYS A 1 21  ? 1.93585   14.77350  24.09530  1.000 36.82429  ? 20  LYS A N    1 
ATOM   176  C CA   . LYS A 1 21  ? 2.65251   14.89442  22.80211  1.000 43.14613  ? 20  LYS A CA   1 
ATOM   177  C C    . LYS A 1 21  ? 4.16258   14.80677  23.02476  1.000 41.74949  ? 20  LYS A C    1 
ATOM   178  O O    . LYS A 1 21  ? 4.80657   14.05478  22.30974  1.000 42.52919  ? 20  LYS A O    1 
ATOM   179  C CB   . LYS A 1 21  ? 2.28008   16.20022  22.10197  1.000 42.43557  ? 20  LYS A CB   1 
ATOM   180  C CG   . LYS A 1 21  ? 2.87671   16.39110  20.71879  1.000 42.58361  ? 20  LYS A CG   1 
ATOM   181  C CD   . LYS A 1 21  ? 1.85338   16.77771  19.68697  1.000 66.84097  ? 20  LYS A CD   1 
ATOM   182  C CE   . LYS A 1 21  ? 1.73803   18.27566  19.49373  1.000 79.47777  ? 20  LYS A CE   1 
ATOM   183  N NZ   . LYS A 1 21  ? 1.06765   18.61729  18.21784  1.000 71.80903  ? 20  LYS A NZ   1 
ATOM   184  N N    . ARG A 1 22  ? 4.67667   15.53705  24.00251  1.000 35.53996  ? 21  ARG A N    1 
ATOM   185  C CA   . ARG A 1 22  ? 6.12275   15.48740  24.31518  1.000 45.59083  ? 21  ARG A CA   1 
ATOM   186  C C    . ARG A 1 22  ? 6.54812   14.04955  24.62733  1.000 37.51236  ? 21  ARG A C    1 
ATOM   187  O O    . ARG A 1 22  ? 7.57308   13.62967  24.09615  1.000 40.26206  ? 21  ARG A O    1 
ATOM   188  C CB   . ARG A 1 22  ? 6.44385   16.39868  25.50394  1.000 43.23071  ? 21  ARG A CB   1 
ATOM   189  C CG   . ARG A 1 22  ? 7.02948   17.75073  25.12657  1.000 57.18622  ? 21  ARG A CG   1 
ATOM   190  C CD   . ARG A 1 22  ? 6.89254   18.75990  26.25242  1.000 50.78290  ? 21  ARG A CD   1 
ATOM   191  N NE   . ARG A 1 22  ? 5.97923   19.83265  25.89845  1.000 59.58679  ? 21  ARG A NE   1 
ATOM   192  C CZ   . ARG A 1 22  ? 5.02732   20.31559  26.68660  1.000 66.07271  ? 21  ARG A CZ   1 
ATOM   193  N NH1  . ARG A 1 22  ? 4.85171   19.82477  27.90272  1.000 54.56253  ? 21  ARG A NH1  1 
ATOM   194  N NH2  . ARG A 1 22  ? 4.25501   21.29636  26.26061  1.000 70.21592  ? 21  ARG A NH2  1 
ATOM   195  N N    . LEU A 1 23  ? 5.78747   13.35053  25.46463  1.000 39.44008  ? 22  LEU A N    1 
ATOM   196  C CA   . LEU A 1 23  ? 6.15385   11.97869  25.89678  1.000 47.78195  ? 22  LEU A CA   1 
ATOM   197  C C    . LEU A 1 23  ? 6.15576   11.03248  24.69695  1.000 33.15542  ? 22  LEU A C    1 
ATOM   198  O O    . LEU A 1 23  ? 7.06391   10.21465  24.61887  1.000 47.88189  ? 22  LEU A O    1 
ATOM   199  C CB   . LEU A 1 23  ? 5.14920   11.52466  26.95710  1.000 44.23056  ? 22  LEU A CB   1 
ATOM   200  C CG   . LEU A 1 23  ? 5.20137   12.26091  28.28996  1.000 49.60556  ? 22  LEU A CG   1 
ATOM   201  C CD1  . LEU A 1 23  ? 3.88257   12.11176  29.02530  1.000 42.74418  ? 22  LEU A CD1  1 
ATOM   202  C CD2  . LEU A 1 23  ? 6.34668   11.74529  29.14078  1.000 48.09618  ? 22  LEU A CD2  1 
ATOM   203  N N    . LEU A 1 24  ? 5.17652   11.16612  23.80816  1.000 36.60040  ? 23  LEU A N    1 
ATOM   204  C CA   . LEU A 1 24  ? 5.06442   10.28289  22.61934  1.000 48.90982  ? 23  LEU A CA   1 
ATOM   205  C C    . LEU A 1 24  ? 6.26216   10.50198  21.69501  1.000 42.46315  ? 23  LEU A C    1 
ATOM   206  O O    . LEU A 1 24  ? 6.75423   9.52398   21.14507  1.000 37.07015  ? 23  LEU A O    1 
ATOM   207  C CB   . LEU A 1 24  ? 3.74819   10.59849  21.89959  1.000 45.80852  ? 23  LEU A CB   1 
ATOM   208  C CG   . LEU A 1 24  ? 2.49346   9.88832   22.41202  1.000 61.83550  ? 23  LEU A CG   1 
ATOM   209  C CD1  . LEU A 1 24  ? 2.14370   10.34149  23.81702  1.000 71.44449  ? 23  LEU A CD1  1 
ATOM   210  C CD2  . LEU A 1 24  ? 1.30719   10.07991  21.47827  1.000 67.10083  ? 23  LEU A CD2  1 
ATOM   211  N N    . GLU A 1 25  ? 6.68986   11.74804  21.54169  1.000 36.55983  ? 24  GLU A N    1 
ATOM   212  C CA   . GLU A 1 25  ? 7.83958   12.09312  20.67136  1.000 34.97822  ? 24  GLU A CA   1 
ATOM   213  C C    . GLU A 1 25  ? 9.13984   11.54049  21.26115  1.000 48.99045  ? 24  GLU A C    1 
ATOM   214  O O    . GLU A 1 25  ? 9.97475   11.09053  20.48503  1.000 44.67516  ? 24  GLU A O    1 
ATOM   215  C CB   . GLU A 1 25  ? 7.89623   13.60710  20.48208  1.000 46.63971  ? 24  GLU A CB   1 
ATOM   216  C CG   . GLU A 1 25  ? 6.82789   14.13672  19.54524  1.000 56.28122  ? 24  GLU A CG   1 
ATOM   217  C CD   . GLU A 1 25  ? 6.40364   15.58167  19.74809  1.000 60.46204  ? 24  GLU A CD   1 
ATOM   218  O OE1  . GLU A 1 25  ? 6.75277   16.16492  20.78891  1.000 64.59478  ? 24  GLU A OE1  1 
ATOM   219  O OE2  . GLU A 1 25  ? 5.71132   16.11337  18.86117  1.000 65.87992  ? 24  GLU A OE2  1 
ATOM   220  N N    . LYS A 1 26  ? 9.28015   11.55376  22.58711  1.000 43.69276  ? 25  LYS A N    1 
ATOM   221  C CA   . LYS A 1 26  ? 10.47043  10.96912  23.24893  1.000 47.56531  ? 25  LYS A CA   1 
ATOM   222  C C    . LYS A 1 26  ? 10.50669  9.45708   23.02318  1.000 41.36814  ? 25  LYS A C    1 
ATOM   223  O O    . LYS A 1 26  ? 11.56972  8.94325   22.70502  1.000 41.97201  ? 25  LYS A O    1 
ATOM   224  C CB   . LYS A 1 26  ? 10.44972  11.30837  24.73787  1.000 51.58874  ? 25  LYS A CB   1 
ATOM   225  C CG   . LYS A 1 26  ? 11.64001  10.82076  25.54168  1.000 55.74648  ? 25  LYS A CG   1 
ATOM   226  C CD   . LYS A 1 26  ? 11.77019  11.50202  26.88153  1.000 56.20192  ? 25  LYS A CD   1 
ATOM   227  C CE   . LYS A 1 26  ? 12.76155  10.81538  27.79741  1.000 60.61351  ? 25  LYS A CE   1 
ATOM   228  N NZ   . LYS A 1 26  ? 12.20694  9.56537   28.36476  1.000 64.70496  ? 25  LYS A NZ   1 
ATOM   229  N N    . ASP A 1 27  ? 9.36987   8.79088   23.18557  1.000 41.87733  ? 26  ASP A N    1 
ATOM   230  C CA   . ASP A 1 27  ? 9.27412   7.32582   22.98385  1.000 47.99206  ? 26  ASP A CA   1 
ATOM   231  C C    . ASP A 1 27  ? 9.56284   6.97663   21.51384  1.000 49.58570  ? 26  ASP A C    1 
ATOM   232  O O    . ASP A 1 27  ? 10.26299  5.99973   21.27884  1.000 49.09164  ? 26  ASP A O    1 
ATOM   233  C CB   . ASP A 1 27  ? 7.92034   6.81063   23.46226  1.000 50.32142  ? 26  ASP A CB   1 
ATOM   234  C CG   . ASP A 1 27  ? 7.90173   5.33368   23.78752  1.000 52.31041  ? 26  ASP A CG   1 
ATOM   235  O OD1  . ASP A 1 27  ? 8.92095   4.82997   24.27437  1.000 67.16784  ? 26  ASP A OD1  1 
ATOM   236  O OD2  . ASP A 1 27  ? 6.86580   4.71142   23.54888  1.000 52.38944  ? 26  ASP A OD2  1 
ATOM   237  N N    . GLU A 1 28  ? 9.04846   7.76636   20.57483  1.000 43.66896  ? 27  GLU A N    1 
ATOM   238  C CA   . GLU A 1 28  ? 9.32516   7.53516   19.13880  1.000 54.41717  ? 27  GLU A CA   1 
ATOM   239  C C    . GLU A 1 28  ? 10.82607  7.66543   18.88142  1.000 56.65856  ? 27  GLU A C    1 
ATOM   240  O O    . GLU A 1 28  ? 11.35408  6.81642   18.18244  1.000 48.46127  ? 27  GLU A O    1 
ATOM   241  C CB   . GLU A 1 28  ? 8.53275   8.51485   18.27382  1.000 52.43978  ? 27  GLU A CB   1 
ATOM   242  C CG   . GLU A 1 28  ? 8.40951   8.03757   16.84593  1.000 62.46142  ? 27  GLU A CG   1 
ATOM   243  C CD   . GLU A 1 28  ? 7.39416   8.80822   16.03104  1.000 81.64556  ? 27  GLU A CD   1 
ATOM   244  O OE1  . GLU A 1 28  ? 7.76381   9.85820   15.47877  1.000 72.93782  ? 27  GLU A OE1  1 
ATOM   245  O OE2  . GLU A 1 28  ? 6.24123   8.35097   15.94639  1.000 66.21026  ? 27  GLU A OE2  1 
ATOM   246  N N    . ARG A 1 29  ? 11.47200  8.67666   19.46009  1.000 45.18701  ? 28  ARG A N    1 
ATOM   247  C CA   . ARG A 1 29  ? 12.92592  8.89393   19.28771  1.000 51.58577  ? 28  ARG A CA   1 
ATOM   248  C C    . ARG A 1 29  ? 13.72229  7.71219   19.83372  1.000 57.57644  ? 28  ARG A C    1 
ATOM   249  O O    . ARG A 1 29  ? 14.62122  7.25426   19.13359  1.000 52.26863  ? 28  ARG A O    1 
ATOM   250  C CB   . ARG A 1 29  ? 13.37683  10.15116  20.02138  1.000 48.86367  ? 28  ARG A CB   1 
ATOM   251  C CG   . ARG A 1 29  ? 13.70037  11.33207  19.12010  1.000 65.08783  ? 28  ARG A CG   1 
ATOM   252  C CD   . ARG A 1 29  ? 14.17832  12.52530  19.92177  1.000 64.71039  ? 28  ARG A CD   1 
ATOM   253  N NE   . ARG A 1 29  ? 13.08124  13.39015  20.33788  1.000 63.86058  ? 28  ARG A NE   1 
ATOM   254  C CZ   . ARG A 1 29  ? 12.67450  13.55328  21.58995  1.000 54.97304  ? 28  ARG A CZ   1 
ATOM   255  N NH1  . ARG A 1 29  ? 13.27487  12.91358  22.57892  1.000 58.40209  ? 28  ARG A NH1  1 
ATOM   256  N NH2  . ARG A 1 29  ? 11.66640  14.36412  21.85205  1.000 60.12839  ? 28  ARG A NH2  1 
ATOM   257  N N    . LEU A 1 30  ? 13.39567  7.25034   21.03888  1.000 48.83206  ? 29  LEU A N    1 
ATOM   258  C CA   . LEU A 1 30  ? 14.19605  6.16261   21.66188  1.000 58.77698  ? 29  LEU A CA   1 
ATOM   259  C C    . LEU A 1 30  ? 13.99513  4.86543   20.88015  1.000 52.98155  ? 29  LEU A C    1 
ATOM   260  O O    . LEU A 1 30  ? 14.97825  4.12961   20.73305  1.000 69.97059  ? 29  LEU A O    1 
ATOM   261  C CB   . LEU A 1 30  ? 13.84543  6.01980   23.14599  1.000 49.12800  ? 29  LEU A CB   1 
ATOM   262  C CG   . LEU A 1 30  ? 12.41260  5.63757   23.51640  1.000 56.78419  ? 29  LEU A CG   1 
ATOM   263  C CD1  . LEU A 1 30  ? 12.28395  4.13457   23.70369  1.000 63.12833  ? 29  LEU A CD1  1 
ATOM   264  C CD2  . LEU A 1 30  ? 11.99175  6.35570   24.79037  1.000 74.82368  ? 29  LEU A CD2  1 
ATOM   265  N N    . LEU A 1 31  ? 12.79006  4.62809   20.36948  1.000 53.76455  ? 30  LEU A N    1 
ATOM   266  C CA   . LEU A 1 31  ? 12.50613  3.39190   19.60276  1.000 55.01716  ? 30  LEU A CA   1 
ATOM   267  C C    . LEU A 1 31  ? 13.24480  3.46282   18.26358  1.000 59.36559  ? 30  LEU A C    1 
ATOM   268  O O    . LEU A 1 31  ? 13.83491  2.45187   17.86661  1.000 56.95653  ? 30  LEU A O    1 
ATOM   269  C CB   . LEU A 1 31  ? 10.99113  3.21156   19.44216  1.000 44.62624  ? 30  LEU A CB   1 
ATOM   270  C CG   . LEU A 1 31  ? 10.26053  2.70763   20.68242  1.000 63.66787  ? 30  LEU A CG   1 
ATOM   271  C CD1  . LEU A 1 31  ? 8.78250   2.50027   20.40181  1.000 61.38747  ? 30  LEU A CD1  1 
ATOM   272  C CD2  . LEU A 1 31  ? 10.88892  1.42585   21.20449  1.000 46.53786  ? 30  LEU A CD2  1 
ATOM   273  N N    . ARG A 1 32  ? 13.24240  4.63071   17.62837  1.000 64.99552  ? 31  ARG A N    1 
ATOM   274  C CA   . ARG A 1 32  ? 13.98006  4.82864   16.36316  1.000 54.72047  ? 31  ARG A CA   1 
ATOM   275  C C    . ARG A 1 32  ? 15.47016  4.59499   16.59585  1.000 60.96973  ? 31  ARG A C    1 
ATOM   276  O O    . ARG A 1 32  ? 16.06811  3.90797   15.76883  1.000 62.82852  ? 31  ARG A O    1 
ATOM   277  C CB   . ARG A 1 32  ? 13.77165  6.25551   15.86096  1.000 52.14415  ? 31  ARG A CB   1 
ATOM   278  C CG   . ARG A 1 32  ? 14.09925  6.47332   14.38985  1.000 59.32784  ? 31  ARG A CG   1 
ATOM   279  C CD   . ARG A 1 32  ? 14.03485  7.93424   13.97861  1.000 74.35346  ? 31  ARG A CD   1 
ATOM   280  N NE   . ARG A 1 32  ? 12.83682  8.62307   14.43977  1.000 58.63932  ? 31  ARG A NE   1 
ATOM   281  C CZ   . ARG A 1 32  ? 12.82975  9.74819   15.14758  1.000 85.41663  ? 31  ARG A CZ   1 
ATOM   282  N NH1  . ARG A 1 32  ? 13.96171  10.33548  15.47921  1.000 79.44518  ? 31  ARG A NH1  1 
ATOM   283  N NH2  . ARG A 1 32  ? 11.67873  10.28302  15.51676  1.000 63.25357  ? 31  ARG A NH2  1 
ATOM   284  N N    . GLU A 1 33  ? 16.03430  5.15929   17.66062  1.000 61.73169  ? 32  GLU A N    1 
ATOM   285  C CA   . GLU A 1 33  ? 17.49239  5.04564   17.91429  1.000 54.82450  ? 32  GLU A CA   1 
ATOM   286  C C    . GLU A 1 33  ? 17.87273  3.57874   18.06345  1.000 64.61927  ? 32  GLU A C    1 
ATOM   287  O O    . GLU A 1 33  ? 18.88867  3.18585   17.48528  1.000 72.73577  ? 32  GLU A O    1 
ATOM   288  C CB   . GLU A 1 33  ? 17.89153  5.81494   19.17206  1.000 66.27229  ? 32  GLU A CB   1 
ATOM   289  C CG   . GLU A 1 33  ? 19.38659  5.80929   19.41270  1.000 72.23899  ? 32  GLU A CG   1 
ATOM   290  C CD   . GLU A 1 33  ? 19.81780  6.32562   20.76951  1.000 86.27962  ? 32  GLU A CD   1 
ATOM   291  O OE1  . GLU A 1 33  ? 19.38416  5.74571   21.78472  1.000 90.36061  ? 32  GLU A OE1  1 
ATOM   292  O OE2  . GLU A 1 33  ? 20.57761  7.30678   20.81516  1.000 76.98631  ? 32  GLU A OE2  1 
ATOM   293  N N    . PHE A 1 34  ? 17.07706  2.81671   18.80178  1.000 60.60987  ? 33  PHE A N    1 
ATOM   294  C CA   . PHE A 1 34  ? 17.37740  1.38281   19.00995  1.000 65.57767  ? 33  PHE A CA   1 
ATOM   295  C C    . PHE A 1 34  ? 17.41023  0.65958   17.66607  1.000 73.05068  ? 33  PHE A C    1 
ATOM   296  O O    . PHE A 1 34  ? 18.38132  -0.05526  17.41797  1.000 79.67673  ? 33  PHE A O    1 
ATOM   297  C CB   . PHE A 1 34  ? 16.33976  0.74175   19.93031  1.000 69.59759  ? 33  PHE A CB   1 
ATOM   298  N N    . TYR A 1 35  ? 16.38800  0.85422   16.83328  1.000 75.47530  ? 34  TYR A N    1 
ATOM   299  C CA   . TYR A 1 35  ? 16.26884  0.13597   15.54144  1.000 69.79499  ? 34  TYR A CA   1 
ATOM   300  C C    . TYR A 1 35  ? 17.31049  0.62701   14.53110  1.000 73.45951  ? 34  TYR A C    1 
ATOM   301  O O    . TYR A 1 35  ? 17.66244  -0.15407  13.63815  1.000 78.22078  ? 34  TYR A O    1 
ATOM   302  C CB   . TYR A 1 35  ? 14.82569  0.29159   15.05275  1.000 63.12487  ? 34  TYR A CB   1 
ATOM   303  C CG   . TYR A 1 35  ? 14.35266  -0.73368  14.05504  1.000 74.11379  ? 34  TYR A CG   1 
ATOM   304  C CD1  . TYR A 1 35  ? 13.78101  -1.92573  14.46539  1.000 62.28209  ? 34  TYR A CD1  1 
ATOM   305  C CD2  . TYR A 1 35  ? 14.45929  -0.49090  12.69898  1.000 73.40167  ? 34  TYR A CD2  1 
ATOM   306  C CE1  . TYR A 1 35  ? 13.33898  -2.86098  13.54766  1.000 75.43870  ? 34  TYR A CE1  1 
ATOM   307  C CE2  . TYR A 1 35  ? 14.02526  -1.41715  11.76524  1.000 78.11484  ? 34  TYR A CE2  1 
ATOM   308  C CZ   . TYR A 1 35  ? 13.46460  -2.60319  12.19258  1.000 66.50286  ? 34  TYR A CZ   1 
ATOM   309  O OH   . TYR A 1 35  ? 13.04757  -3.50544  11.26584  1.000 81.04709  ? 34  TYR A OH   1 
ATOM   310  N N    . ARG A 1 36  ? 17.78927  1.86513   14.66177  1.000 73.37363  ? 35  ARG A N    1 
ATOM   311  C CA   . ARG A 1 36  ? 18.82194  2.41419   13.74343  1.000 70.64254  ? 35  ARG A CA   1 
ATOM   312  C C    . ARG A 1 36  ? 20.21014  1.93955   14.18218  1.000 72.98796  ? 35  ARG A C    1 
ATOM   313  O O    . ARG A 1 36  ? 21.15592  2.11861   13.40593  1.000 80.87537  ? 35  ARG A O    1 
ATOM   314  C CB   . ARG A 1 36  ? 18.68560  3.94014   13.64920  1.000 79.80985  ? 35  ARG A CB   1 
ATOM   315  C CG   . ARG A 1 36  ? 19.56965  4.75049   14.58284  1.000 74.87540  ? 35  ARG A CG   1 
ATOM   316  C CD   . ARG A 1 36  ? 19.39930  6.24542   14.38862  1.000 81.43550  ? 35  ARG A CD   1 
ATOM   317  N NE   . ARG A 1 36  ? 18.24337  6.74931   15.11581  1.000 95.00417  ? 35  ARG A NE   1 
ATOM   318  C CZ   . ARG A 1 36  ? 18.04519  8.01732   15.45464  1.000 85.33291  ? 35  ARG A CZ   1 
ATOM   319  N NH1  . ARG A 1 36  ? 18.92992  8.94545   15.12727  1.000 83.85478  ? 35  ARG A NH1  1 
ATOM   320  N NH2  . ARG A 1 36  ? 16.96228  8.35722   16.12784  1.000 72.43844  ? 35  ARG A NH2  1 
ATOM   321  N N    . ARG A 1 37  ? 20.31955  1.32978   15.36126  1.000 80.17293  ? 36  ARG A N    1 
ATOM   322  C CA   . ARG A 1 37  ? 21.60778  0.75913   15.83005  1.000 81.92630  ? 36  ARG A CA   1 
ATOM   323  C C    . ARG A 1 37  ? 21.90085  -0.51095  15.02321  1.000 83.63708  ? 36  ARG A C    1 
ATOM   324  O O    . ARG A 1 37  ? 21.03103  -1.40413  15.01257  1.000 85.81825  ? 36  ARG A O    1 
ATOM   325  C CB   . ARG A 1 37  ? 21.53920  0.43037   17.32113  1.000 70.67990  ? 36  ARG A CB   1 
ATOM   326  C CG   . ARG A 1 37  ? 21.67117  1.63956   18.23589  1.000 66.61874  ? 36  ARG A CG   1 
ATOM   327  C CD   . ARG A 1 37  ? 21.86760  1.22585   19.67991  1.000 83.00633  ? 36  ARG A CD   1 
ATOM   328  N NE   . ARG A 1 37  ? 20.64875  1.36773   20.45318  1.000 90.75689  ? 36  ARG A NE   1 
ATOM   329  C CZ   . ARG A 1 37  ? 20.48081  2.22987   21.45107  1.000 85.26055  ? 36  ARG A CZ   1 
ATOM   330  N NH1  . ARG A 1 37  ? 21.46773  3.03614   21.80569  1.000 84.88370  ? 36  ARG A NH1  1 
ATOM   331  N NH2  . ARG A 1 37  ? 19.32795  2.28575   22.09233  1.000 81.98378  ? 36  ARG A NH2  1 
ATOM   332  N N    . ASP A 1 41  ? 21.39512  -5.34913  20.36717  1.000 76.74094  ? 40  ASP A N    1 
ATOM   333  C CA   . ASP A 1 41  ? 21.88248  -5.48978  21.76508  1.000 77.43193  ? 40  ASP A CA   1 
ATOM   334  C C    . ASP A 1 41  ? 20.70978  -5.89787  22.65843  1.000 94.34277  ? 40  ASP A C    1 
ATOM   335  O O    . ASP A 1 41  ? 19.65462  -5.24810  22.55857  1.000 97.81733  ? 40  ASP A O    1 
ATOM   336  C CB   . ASP A 1 41  ? 22.59933  -4.22055  22.23369  1.000 83.36842  ? 40  ASP A CB   1 
ATOM   337  N N    . LYS A 1 42  ? 20.89019  -6.91468  23.50056  1.000 73.70390  ? 41  LYS A N    1 
ATOM   338  C CA   . LYS A 1 42  ? 19.75649  -7.44378  24.30293  1.000 83.85692  ? 41  LYS A CA   1 
ATOM   339  C C    . LYS A 1 42  ? 19.42158  -6.52064  25.47385  1.000 91.24026  ? 41  LYS A C    1 
ATOM   340  O O    . LYS A 1 42  ? 18.22460  -6.30385  25.72509  1.000 94.60655  ? 41  LYS A O    1 
ATOM   341  C CB   . LYS A 1 42  ? 20.06790  -8.85163  24.81110  1.000 85.49644  ? 41  LYS A CB   1 
ATOM   342  C CG   . LYS A 1 42  ? 19.84689  -9.96385  23.79734  1.000 85.04009  ? 41  LYS A CG   1 
ATOM   343  C CD   . LYS A 1 42  ? 19.03826  -11.11392 24.34974  1.000 108.35863 ? 41  LYS A CD   1 
ATOM   344  C CE   . LYS A 1 42  ? 19.76152  -12.43979 24.25880  1.000 108.87390 ? 41  LYS A CE   1 
ATOM   345  N NZ   . LYS A 1 42  ? 19.03591  -13.50781 24.98416  1.000 107.20591 ? 41  LYS A NZ   1 
ATOM   346  N N    . GLU A 1 43  ? 20.42965  -6.02831  26.17952  1.000 79.39234  ? 42  GLU A N    1 
ATOM   347  C CA   . GLU A 1 43  ? 20.14276  -5.20616  27.37744  1.000 86.31135  ? 42  GLU A CA   1 
ATOM   348  C C    . GLU A 1 43  ? 19.73836  -3.81433  26.91630  1.000 82.63878  ? 42  GLU A C    1 
ATOM   349  O O    . GLU A 1 43  ? 19.14240  -3.08631  27.71331  1.000 86.67993  ? 42  GLU A O    1 
ATOM   350  C CB   . GLU A 1 43  ? 21.35897  -5.17075  28.29815  1.000 94.21440  ? 42  GLU A CB   1 
ATOM   351  C CG   . GLU A 1 43  ? 21.48644  -6.40957  29.16233  1.000 102.15494 ? 42  GLU A CG   1 
ATOM   352  C CD   . GLU A 1 43  ? 20.52773  -6.46857  30.33857  1.000 101.11218 ? 42  GLU A CD   1 
ATOM   353  O OE1  . GLU A 1 43  ? 20.80083  -5.80333  31.35639  1.000 92.13174  ? 42  GLU A OE1  1 
ATOM   354  O OE2  . GLU A 1 43  ? 19.51685  -7.18679  30.23694  1.000 101.38809 ? 42  GLU A OE2  1 
ATOM   355  N N    . GLU A 1 44  ? 20.07400  -3.47047  25.68016  1.000 85.10593  ? 43  GLU A N    1 
ATOM   356  C CA   . GLU A 1 44  ? 19.65460  -2.17266  25.11703  1.000 85.03751  ? 43  GLU A CA   1 
ATOM   357  C C    . GLU A 1 44  ? 18.15154  -2.22701  24.85640  1.000 79.78701  ? 43  GLU A C    1 
ATOM   358  O O    . GLU A 1 44  ? 17.51435  -1.18113  24.93137  1.000 81.20027  ? 43  GLU A O    1 
ATOM   359  C CB   . GLU A 1 44  ? 20.43924  -1.91272  23.83880  1.000 82.58058  ? 43  GLU A CB   1 
ATOM   360  C CG   . GLU A 1 44  ? 20.98892  -0.50562  23.73142  1.000 99.17719  ? 43  GLU A CG   1 
ATOM   361  C CD   . GLU A 1 44  ? 21.59511  0.06272   25.00118  1.000 109.92553 ? 43  GLU A CD   1 
ATOM   362  O OE1  . GLU A 1 44  ? 22.62633  -0.47498  25.45603  1.000 120.01728 ? 43  GLU A OE1  1 
ATOM   363  O OE2  . GLU A 1 44  ? 21.04103  1.04970   25.52314  1.000 105.20884 ? 43  GLU A OE2  1 
ATOM   364  N N    . PHE A 1 45  ? 17.62272  -3.41317  24.57873  1.000 70.70722  ? 44  PHE A N    1 
ATOM   365  C CA   . PHE A 1 45  ? 16.16471  -3.56651  24.38411  1.000 74.50611  ? 44  PHE A CA   1 
ATOM   366  C C    . PHE A 1 45  ? 15.48603  -3.53041  25.74726  1.000 79.89408  ? 44  PHE A C    1 
ATOM   367  O O    . PHE A 1 45  ? 14.46092  -2.86560  25.86839  1.000 77.00074  ? 44  PHE A O    1 
ATOM   368  C CB   . PHE A 1 45  ? 15.83280  -4.86870  23.65541  1.000 62.59368  ? 44  PHE A CB   1 
ATOM   369  N N    . ARG A 1 46  ? 16.03741  -4.24113  26.72825  1.000 74.26858  ? 45  ARG A N    1 
ATOM   370  C CA   . ARG A 1 46  ? 15.46371  -4.15601  28.08938  1.000 75.27621  ? 45  ARG A CA   1 
ATOM   371  C C    . ARG A 1 46  ? 15.36250  -2.68096  28.45314  1.000 73.37185  ? 45  ARG A C    1 
ATOM   372  O O    . ARG A 1 46  ? 14.35455  -2.30007  29.02932  1.000 80.13410  ? 45  ARG A O    1 
ATOM   373  C CB   . ARG A 1 46  ? 16.34111  -4.90365  29.09130  1.000 84.49080  ? 45  ARG A CB   1 
ATOM   374  C CG   . ARG A 1 46  ? 16.23640  -6.41769  28.99459  1.000 93.78356  ? 45  ARG A CG   1 
ATOM   375  C CD   . ARG A 1 46  ? 15.90585  -7.04552  30.33378  1.000 101.98085 ? 45  ARG A CD   1 
ATOM   376  N NE   . ARG A 1 46  ? 16.71899  -6.50617  31.41449  1.000 99.10706  ? 45  ARG A NE   1 
ATOM   377  C CZ   . ARG A 1 46  ? 16.51435  -6.73998  32.70458  1.000 109.11953 ? 45  ARG A CZ   1 
ATOM   378  N NH1  . ARG A 1 46  ? 15.51260  -7.51312  33.09095  1.000 105.04868 ? 45  ARG A NH1  1 
ATOM   379  N NH2  . ARG A 1 46  ? 17.31345  -6.19966  33.60729  1.000 110.96609 ? 45  ARG A NH2  1 
ATOM   380  N N    . ARG A 1 47  ? 16.35724  -1.89183  28.06777  1.000 58.94861  ? 46  ARG A N    1 
ATOM   381  C CA   . ARG A 1 47  ? 16.38903  -0.45576  28.41451  1.000 77.88129  ? 46  ARG A CA   1 
ATOM   382  C C    . ARG A 1 47  ? 15.25271  0.28488   27.71565  1.000 68.15841  ? 46  ARG A C    1 
ATOM   383  O O    . ARG A 1 47  ? 14.48674  0.94885   28.41272  1.000 71.67187  ? 46  ARG A O    1 
ATOM   384  C CB   . ARG A 1 47  ? 17.72880  0.15045   27.99709  1.000 77.90446  ? 46  ARG A CB   1 
ATOM   385  N N    . VAL A 1 48  ? 15.16541  0.17864   26.39669  1.000 70.69815  ? 47  VAL A N    1 
ATOM   386  C CA   . VAL A 1 48  ? 14.13807  0.94829   25.63780  1.000 70.13338  ? 47  VAL A CA   1 
ATOM   387  C C    . VAL A 1 48  ? 12.73827  0.51808   26.09021  1.000 63.81588  ? 47  VAL A C    1 
ATOM   388  O O    . VAL A 1 48  ? 11.86411  1.37591   26.14327  1.000 49.41296  ? 47  VAL A O    1 
ATOM   389  C CB   . VAL A 1 48  ? 14.33275  0.78907   24.12078  1.000 50.88449  ? 47  VAL A CB   1 
ATOM   390  C CG1  . VAL A 1 48  ? 15.73756  1.17328   23.68438  1.000 81.39608  ? 47  VAL A CG1  1 
ATOM   391  C CG2  . VAL A 1 48  ? 13.97691  -0.59909  23.62011  1.000 72.12148  ? 47  VAL A CG2  1 
ATOM   392  N N    . ILE A 1 49  ? 12.56461  -0.75690  26.42547  1.000 53.92023  ? 48  ILE A N    1 
ATOM   393  C CA   . ILE A 1 49  ? 11.22882  -1.27710  26.82688  1.000 58.65184  ? 48  ILE A CA   1 
ATOM   394  C C    . ILE A 1 49  ? 10.86301  -0.66694  28.18386  1.000 56.69568  ? 48  ILE A C    1 
ATOM   395  O O    . ILE A 1 49  ? 9.70898   -0.29715  28.35008  1.000 54.54640  ? 48  ILE A O    1 
ATOM   396  C CB   . ILE A 1 49  ? 11.20514  -2.81911  26.82716  1.000 46.15018  ? 48  ILE A CB   1 
ATOM   397  C CG1  . ILE A 1 49  ? 11.00392  -3.37439  25.41930  1.000 53.96295  ? 48  ILE A CG1  1 
ATOM   398  C CG2  . ILE A 1 49  ? 10.16648  -3.37015  27.79650  1.000 48.91170  ? 48  ILE A CG2  1 
ATOM   399  C CD1  . ILE A 1 49  ? 9.57779   -3.30277  24.93563  1.000 64.78670  ? 48  ILE A CD1  1 
ATOM   400  N N    . LYS A 1 50  ? 11.82721  -0.54958  29.09061  1.000 60.43086  ? 49  LYS A N    1 
ATOM   401  C CA   . LYS A 1 50  ? 11.54942  -0.00641  30.44659  1.000 64.51751  ? 49  LYS A CA   1 
ATOM   402  C C    . LYS A 1 50  ? 11.15409  1.46349   30.33842  1.000 63.45654  ? 49  LYS A C    1 
ATOM   403  O O    . LYS A 1 50  ? 10.20117  1.85341   31.00658  1.000 60.96538  ? 49  LYS A O    1 
ATOM   404  C CB   . LYS A 1 50  ? 12.76367  -0.18500  31.35833  1.000 69.84383  ? 49  LYS A CB   1 
ATOM   405  C CG   . LYS A 1 50  ? 13.04507  -1.61886  31.77851  1.000 78.05648  ? 49  LYS A CG   1 
ATOM   406  C CD   . LYS A 1 50  ? 12.81947  -1.86765  33.25061  1.000 83.04316  ? 49  LYS A CD   1 
ATOM   407  C CE   . LYS A 1 50  ? 13.78582  -2.88135  33.82855  1.000 74.92626  ? 49  LYS A CE   1 
ATOM   408  N NZ   . LYS A 1 50  ? 14.57397  -2.31000  34.94427  1.000 93.78295  ? 49  LYS A NZ   1 
ATOM   409  N N    . LEU A 1 51  ? 11.86973  2.22950   29.51712  1.000 59.58828  ? 50  LEU A N    1 
ATOM   410  C CA   . LEU A 1 51  ? 11.55739  3.66840   29.33094  1.000 63.65672  ? 50  LEU A CA   1 
ATOM   411  C C    . LEU A 1 51  ? 10.21719  3.82300   28.61224  1.000 53.04668  ? 50  LEU A C    1 
ATOM   412  O O    . LEU A 1 51  ? 9.49208   4.75591   28.94725  1.000 57.53055  ? 50  LEU A O    1 
ATOM   413  C CB   . LEU A 1 51  ? 12.70007  4.29750   28.53056  1.000 67.29395  ? 50  LEU A CB   1 
ATOM   414  C CG   . LEU A 1 51  ? 14.08025  4.18390   29.16725  1.000 66.91980  ? 50  LEU A CG   1 
ATOM   415  C CD1  . LEU A 1 51  ? 15.15692  4.64995   28.20491  1.000 54.26244  ? 50  LEU A CD1  1 
ATOM   416  C CD2  . LEU A 1 51  ? 14.14439  4.97513   30.46410  1.000 50.92517  ? 50  LEU A CD2  1 
ATOM   417  N N    . ASP A 1 52  ? 9.90815   2.92077   27.68147  1.000 51.74240  ? 51  ASP A N    1 
ATOM   418  C CA   . ASP A 1 52  ? 8.60398   2.95738   26.97177  1.000 57.34395  ? 51  ASP A CA   1 
ATOM   419  C C    . ASP A 1 52  ? 7.49227   2.71233   27.98508  1.000 49.78313  ? 51  ASP A C    1 
ATOM   420  O O    . ASP A 1 52  ? 6.47011   3.38110   27.90521  1.000 47.94355  ? 51  ASP A O    1 
ATOM   421  C CB   . ASP A 1 52  ? 8.56691   1.95717   25.81295  1.000 52.82542  ? 51  ASP A CB   1 
ATOM   422  C CG   . ASP A 1 52  ? 7.29370   2.02176   24.99425  1.000 59.60567  ? 51  ASP A CG   1 
ATOM   423  O OD1  . ASP A 1 52  ? 6.44060   2.85464   25.31630  1.000 68.76848  ? 51  ASP A OD1  1 
ATOM   424  O OD2  . ASP A 1 52  ? 7.16164   1.21257   24.06342  1.000 86.12173  ? 51  ASP A OD2  1 
ATOM   425  N N    . GLU A 1 53  ? 7.70068   1.73652   28.85820  1.000 50.76698  ? 52  GLU A N    1 
ATOM   426  C CA   . GLU A 1 53  ? 6.66499   1.35848   29.84351  1.000 58.62868  ? 52  GLU A CA   1 
ATOM   427  C C    . GLU A 1 53  ? 6.42698   2.52760   30.79936  1.000 44.14455  ? 52  GLU A C    1 
ATOM   428  O O    . GLU A 1 53  ? 5.29204   2.70944   31.23060  1.000 50.09400  ? 52  GLU A O    1 
ATOM   429  C CB   . GLU A 1 53  ? 7.11943   0.10070   30.57262  1.000 50.49100  ? 52  GLU A CB   1 
ATOM   430  C CG   . GLU A 1 53  ? 7.07648   -1.14746  29.71685  1.000 65.40574  ? 52  GLU A CG   1 
ATOM   431  C CD   . GLU A 1 53  ? 7.53091   -2.40324  30.44296  1.000 56.01848  ? 52  GLU A CD   1 
ATOM   432  O OE1  . GLU A 1 53  ? 8.62205   -2.38091  31.03670  1.000 52.60283  ? 52  GLU A OE1  1 
ATOM   433  O OE2  . GLU A 1 53  ? 6.78611   -3.39540  30.41231  1.000 60.36641  ? 52  GLU A OE2  1 
ATOM   434  N N    . GLU A 1 54  ? 7.46588   3.30386   31.06098  1.000 41.08967  ? 53  GLU A N    1 
ATOM   435  C CA   . GLU A 1 54  ? 7.33184   4.48698   31.94081  1.000 49.29966  ? 53  GLU A CA   1 
ATOM   436  C C    . GLU A 1 54  ? 6.52745   5.57269   31.21981  1.000 49.49309  ? 53  GLU A C    1 
ATOM   437  O O    . GLU A 1 54  ? 5.71047   6.21764   31.87389  1.000 36.86913  ? 53  GLU A O    1 
ATOM   438  C CB   . GLU A 1 54  ? 8.72484   4.96734   32.33739  1.000 55.01264  ? 53  GLU A CB   1 
ATOM   439  C CG   . GLU A 1 54  ? 8.72183   6.13451   33.29819  1.000 79.55760  ? 53  GLU A CG   1 
ATOM   440  C CD   . GLU A 1 54  ? 10.11984  6.55887   33.71478  1.000 99.94830  ? 53  GLU A CD   1 
ATOM   441  O OE1  . GLU A 1 54  ? 11.08984  5.95698   33.21466  1.000 96.02506  ? 53  GLU A OE1  1 
ATOM   442  O OE2  . GLU A 1 54  ? 10.22985  7.47704   34.54560  1.000 103.43785 ? 53  GLU A OE2  1 
ATOM   443  N N    . VAL A 1 55  ? 6.74910   5.73951   29.91773  1.000 40.69735  ? 54  VAL A N    1 
ATOM   444  C CA   . VAL A 1 55  ? 5.95871   6.72421   29.12074  1.000 51.42698  ? 54  VAL A CA   1 
ATOM   445  C C    . VAL A 1 55  ? 4.49581   6.28991   29.14917  1.000 33.94590  ? 54  VAL A C    1 
ATOM   446  O O    . VAL A 1 55  ? 3.63066   7.14976   29.30422  1.000 40.62977  ? 54  VAL A O    1 
ATOM   447  C CB   . VAL A 1 55  ? 6.50134   6.83407   27.68160  1.000 45.04385  ? 54  VAL A CB   1 
ATOM   448  C CG1  . VAL A 1 55  ? 5.54697   7.58071   26.76769  1.000 38.85276  ? 54  VAL A CG1  1 
ATOM   449  C CG2  . VAL A 1 55  ? 7.89021   7.44835   27.64316  1.000 42.20384  ? 54  VAL A CG2  1 
ATOM   450  N N    . MET A 1 56  ? 4.26205   4.98884   29.03645  1.000 34.37415  ? 55  MET A N    1 
ATOM   451  C CA   . MET A 1 56  ? 2.88015   4.46655   29.00187  1.000 49.56694  ? 55  MET A CA   1 
ATOM   452  C C    . MET A 1 56  ? 2.19640   4.79064   30.32698  1.000 37.12921  ? 55  MET A C    1 
ATOM   453  O O    . MET A 1 56  ? 1.05330   5.24740   30.29917  1.000 43.46789  ? 55  MET A O    1 
ATOM   454  C CB   . MET A 1 56  ? 2.87241   2.95551   28.77414  1.000 35.28287  ? 55  MET A CB   1 
ATOM   455  C CG   . MET A 1 56  ? 1.47749   2.37520   28.64357  1.000 45.34800  ? 55  MET A CG   1 
ATOM   456  S SD   . MET A 1 56  ? 0.48202   3.12776   27.32568  1.000 59.27762  ? 55  MET A SD   1 
ATOM   457  C CE   . MET A 1 56  ? 1.27783   2.42667   25.88061  1.000 49.91510  ? 55  MET A CE   1 
ATOM   458  N N    . LYS A 1 57  ? 2.89571   4.57298   31.43485  1.000 47.24489  ? 56  LYS A N    1 
ATOM   459  C CA   . LYS A 1 57  ? 2.32997   4.84909   32.77994  1.000 37.53633  ? 56  LYS A CA   1 
ATOM   460  C C    . LYS A 1 57  ? 1.95469   6.32604   32.89377  1.000 35.08507  ? 56  LYS A C    1 
ATOM   461  O O    . LYS A 1 57  ? 0.80671   6.61786   33.22199  1.000 44.43970  ? 56  LYS A O    1 
ATOM   462  C CB   . LYS A 1 57  ? 3.35630   4.48149   33.85176  1.000 53.71826  ? 56  LYS A CB   1 
ATOM   463  N N    . ARG A 1 58  ? 2.89744   7.21318   32.60239  1.000 38.77452  ? 57  ARG A N    1 
ATOM   464  C CA   . ARG A 1 58  ? 2.63015   8.66514   32.65720  1.000 38.51524  ? 57  ARG A CA   1 
ATOM   465  C C    . ARG A 1 58  ? 1.44986   9.00573   31.74442  1.000 43.23392  ? 57  ARG A C    1 
ATOM   466  O O    . ARG A 1 58  ? 0.56781   9.75063   32.17950  1.000 39.96602  ? 57  ARG A O    1 
ATOM   467  C CB   . ARG A 1 58  ? 3.88990   9.42432   32.24977  1.000 42.30731  ? 57  ARG A CB   1 
ATOM   468  N N    . SER A 1 59  ? 1.42969   8.44352   30.54352  1.000 36.52002  ? 58  SER A N    1 
ATOM   469  C CA   . SER A 1 59  ? 0.37139   8.77413   29.55572  1.000 31.14522  ? 58  SER A CA   1 
ATOM   470  C C    . SER A 1 59  ? -1.00240  8.32293   30.04912  1.000 26.41490  ? 58  SER A C    1 
ATOM   471  O O    . SER A 1 59  ? -1.96460  9.04869   29.84423  1.000 35.44033  ? 58  SER A O    1 
ATOM   472  C CB   . SER A 1 59  ? 0.72920   8.17597   28.22574  1.000 33.71868  ? 58  SER A CB   1 
ATOM   473  O OG   . SER A 1 59  ? 1.96898   8.68214   27.75535  1.000 37.46722  ? 58  SER A OG   1 
ATOM   474  N N    . GLU A 1 60  ? -1.06801  7.16703   30.68534  1.000 29.96079  ? 59  GLU A N    1 
ATOM   475  C CA   . GLU A 1 60  ? -2.34777  6.64586   31.23174  1.000 38.83639  ? 59  GLU A CA   1 
ATOM   476  C C    . GLU A 1 60  ? -2.81167  7.51897   32.40770  1.000 33.13122  ? 59  GLU A C    1 
ATOM   477  O O    . GLU A 1 60  ? -4.01869  7.74373   32.51194  1.000 39.55202  ? 59  GLU A O    1 
ATOM   478  C CB   . GLU A 1 60  ? -2.17737  5.19097   31.66295  1.000 48.70510  ? 59  GLU A CB   1 
ATOM   479  C CG   . GLU A 1 60  ? -3.46022  4.39669   31.58339  1.000 58.52141  ? 59  GLU A CG   1 
ATOM   480  C CD   . GLU A 1 60  ? -3.69942  3.76540   30.22656  1.000 53.73935  ? 59  GLU A CD   1 
ATOM   481  O OE1  . GLU A 1 60  ? -2.74743  3.20150   29.66943  1.000 68.16080  ? 59  GLU A OE1  1 
ATOM   482  O OE2  . GLU A 1 60  ? -4.83755  3.84108   29.73682  1.000 72.69699  ? 59  GLU A OE2  1 
ATOM   483  N N    . GLU A 1 61  ? -1.88058  8.00230   33.23439  1.000 37.16934  ? 60  GLU A N    1 
ATOM   484  C CA   . GLU A 1 61  ? -2.22950  8.91843   34.35231  1.000 46.89834  ? 60  GLU A CA   1 
ATOM   485  C C    . GLU A 1 61  ? -2.78290  10.23021  33.78722  1.000 33.97265  ? 60  GLU A C    1 
ATOM   486  O O    . GLU A 1 61  ? -3.77788  10.72510  34.31037  1.000 39.92595  ? 60  GLU A O    1 
ATOM   487  C CB   . GLU A 1 61  ? -0.99835  9.21083   35.20797  1.000 38.27521  ? 60  GLU A CB   1 
ATOM   488  C CG   . GLU A 1 61  ? -0.48092  8.00407   35.96706  1.000 67.18509  ? 60  GLU A CG   1 
ATOM   489  C CD   . GLU A 1 61  ? 0.78322   8.23647   36.77371  1.000 86.52952  ? 60  GLU A CD   1 
ATOM   490  O OE1  . GLU A 1 61  ? 1.40096   9.30557   36.61238  1.000 69.59862  ? 60  GLU A OE1  1 
ATOM   491  O OE2  . GLU A 1 61  ? 1.14759   7.34668   37.55978  1.000 81.94118  ? 60  GLU A OE2  1 
ATOM   492  N N    . LEU A 1 62  ? -2.15326  10.75016  32.73698  1.000 39.82421  ? 61  LEU A N    1 
ATOM   493  C CA   . LEU A 1 62  ? -2.57967  12.04297  32.15085  1.000 30.90303  ? 61  LEU A CA   1 
ATOM   494  C C    . LEU A 1 62  ? -3.96378  11.87757  31.53021  1.000 28.22936  ? 61  LEU A C    1 
ATOM   495  O O    . LEU A 1 62  ? -4.76395  12.80643  31.62324  1.000 32.57767  ? 61  LEU A O    1 
ATOM   496  C CB   . LEU A 1 62  ? -1.52400  12.46901  31.13453  1.000 33.93324  ? 61  LEU A CB   1 
ATOM   497  C CG   . LEU A 1 62  ? -0.20795  12.94739  31.74313  1.000 40.92814  ? 61  LEU A CG   1 
ATOM   498  C CD1  . LEU A 1 62  ? 0.92182   12.86345  30.73187  1.000 43.09820  ? 61  LEU A CD1  1 
ATOM   499  C CD2  . LEU A 1 62  ? -0.34712  14.36445  32.26991  1.000 44.70474  ? 61  LEU A CD2  1 
ATOM   500  N N    . LEU A 1 63  ? -4.23268  10.70342  30.96148  1.000 32.99781  ? 62  LEU A N    1 
ATOM   501  C CA   . LEU A 1 63  ? -5.54977  10.43804  30.32984  1.000 33.74661  ? 62  LEU A CA   1 
ATOM   502  C C    . LEU A 1 63  ? -6.63752  10.44200  31.40010  1.000 31.00793  ? 62  LEU A C    1 
ATOM   503  O O    . LEU A 1 63  ? -7.68970  11.01574  31.14925  1.000 39.47626  ? 62  LEU A O    1 
ATOM   504  C CB   . LEU A 1 63  ? -5.52367  9.09092   29.60607  1.000 30.20077  ? 62  LEU A CB   1 
ATOM   505  C CG   . LEU A 1 63  ? -6.86172  8.66453   29.00346  1.000 35.30746  ? 62  LEU A CG   1 
ATOM   506  C CD1  . LEU A 1 63  ? -7.22418  9.54625   27.82139  1.000 43.68609  ? 62  LEU A CD1  1 
ATOM   507  C CD2  . LEU A 1 63  ? -6.83652  7.20447   28.59071  1.000 42.46909  ? 62  LEU A CD2  1 
ATOM   508  N N    . LYS A 1 64  ? -6.37811  9.79125   32.52415  1.000 34.28319  ? 63  LYS A N    1 
ATOM   509  C CA   . LYS A 1 64  ? -7.40784  9.69722   33.58441  1.000 39.17543  ? 63  LYS A CA   1 
ATOM   510  C C    . LYS A 1 64  ? -7.69302  11.11325  34.06823  1.000 24.73167  ? 63  LYS A C    1 
ATOM   511  O O    . LYS A 1 64  ? -8.85905  11.45204  34.25745  1.000 40.74241  ? 63  LYS A O    1 
ATOM   512  C CB   . LYS A 1 64  ? -6.92338  8.75351   34.68946  1.000 45.87209  ? 63  LYS A CB   1 
ATOM   513  C CG   . LYS A 1 64  ? -6.66219  7.31849   34.26065  1.000 52.15553  ? 63  LYS A CG   1 
ATOM   514  C CD   . LYS A 1 64  ? -6.52472  6.36572   35.42378  1.000 68.71438  ? 63  LYS A CD   1 
ATOM   515  C CE   . LYS A 1 64  ? -5.75654  5.10882   35.06982  1.000 61.74832  ? 63  LYS A CE   1 
ATOM   516  N NZ   . LYS A 1 64  ? -5.83707  4.09199   36.14301  1.000 79.20159  ? 63  LYS A NZ   1 
ATOM   517  N N    . ARG A 1 65  ? -6.64917  11.92748  34.15484  1.000 36.80135  ? 64  ARG A N    1 
ATOM   518  C CA   . ARG A 1 65  ? -6.82136  13.34351  34.57164  1.000 36.69681  ? 64  ARG A CA   1 
ATOM   519  C C    . ARG A 1 65  ? -7.68976  14.08716  33.54971  1.000 32.91656  ? 64  ARG A C    1 
ATOM   520  O O    . ARG A 1 65  ? -8.59081  14.81604  33.96980  1.000 32.55243  ? 64  ARG A O    1 
ATOM   521  C CB   . ARG A 1 65  ? -5.44845  13.99283  34.76720  1.000 43.98927  ? 64  ARG A CB   1 
ATOM   522  C CG   . ARG A 1 65  ? -4.74506  13.59420  36.05410  1.000 51.96252  ? 64  ARG A CG   1 
ATOM   523  C CD   . ARG A 1 65  ? -3.34215  14.15551  36.14766  1.000 56.39791  ? 64  ARG A CD   1 
ATOM   524  N NE   . ARG A 1 65  ? -3.30949  15.59949  35.97941  1.000 64.82321  ? 64  ARG A NE   1 
ATOM   525  C CZ   . ARG A 1 65  ? -2.19966  16.32671  35.92701  1.000 81.12801  ? 64  ARG A CZ   1 
ATOM   526  N NH1  . ARG A 1 65  ? -1.02051  15.73997  36.03984  1.000 69.47435  ? 64  ARG A NH1  1 
ATOM   527  N NH2  . ARG A 1 65  ? -2.27396  17.63566  35.76380  1.000 65.23027  ? 64  ARG A NH2  1 
ATOM   528  N N    . ALA A 1 66  ? -7.44502  13.86398  32.26569  1.000 34.13270  ? 65  ALA A N    1 
ATOM   529  C CA   . ALA A 1 66  ? -8.19742  14.57064  31.20475  1.000 32.21021  ? 65  ALA A CA   1 
ATOM   530  C C    . ALA A 1 66  ? -9.66633  14.13734  31.21417  1.000 24.34396  ? 65  ALA A C    1 
ATOM   531  O O    . ALA A 1 66  ? -10.53053 15.00014  31.08823  1.000 33.12201  ? 65  ALA A O    1 
ATOM   532  C CB   . ALA A 1 66  ? -7.54369  14.32754  29.86964  1.000 26.97667  ? 65  ALA A CB   1 
ATOM   533  N N    . GLU A 1 67  ? -9.91202  12.84632  31.39146  1.000 27.31841  ? 66  GLU A N    1 
ATOM   534  C CA   . GLU A 1 67  ? -11.29890 12.32304  31.42088  1.000 28.20873  ? 66  GLU A CA   1 
ATOM   535  C C    . GLU A 1 67  ? -12.05676 12.96808  32.58295  1.000 25.71093  ? 66  GLU A C    1 
ATOM   536  O O    . GLU A 1 67  ? -13.21788 13.32581  32.39416  1.000 34.83013  ? 66  GLU A O    1 
ATOM   537  C CB   . GLU A 1 67  ? -11.25357 10.79906  31.50914  1.000 37.20571  ? 66  GLU A CB   1 
ATOM   538  C CG   . GLU A 1 67  ? -10.54071 10.16200  30.33008  1.000 47.19487  ? 66  GLU A CG   1 
ATOM   539  C CD   . GLU A 1 67  ? -10.31138 8.66307   30.43228  1.000 71.08178  ? 66  GLU A CD   1 
ATOM   540  O OE1  . GLU A 1 67  ? -9.55508  8.23638   31.32718  1.000 57.71351  ? 66  GLU A OE1  1 
ATOM   541  O OE2  . GLU A 1 67  ? -10.88443 7.93381   29.60555  1.000 63.73640  ? 66  GLU A OE2  1 
ATOM   542  N N    . GLU A 1 68  ? -11.39352 13.14242  33.72276  1.000 28.67709  ? 67  GLU A N    1 
ATOM   543  C CA   . GLU A 1 68  ? -12.02737 13.75950  34.91780  1.000 36.86021  ? 67  GLU A CA   1 
ATOM   544  C C    . GLU A 1 68  ? -12.38374 15.21037  34.61064  1.000 28.09087  ? 67  GLU A C    1 
ATOM   545  O O    . GLU A 1 68  ? -13.49475 15.62920  34.92783  1.000 36.83320  ? 67  GLU A O    1 
ATOM   546  C CB   . GLU A 1 68  ? -11.08606 13.67190  36.11959  1.000 30.94479  ? 67  GLU A CB   1 
ATOM   547  C CG   . GLU A 1 68  ? -11.57493 14.42401  37.33958  1.000 39.11757  ? 67  GLU A CG   1 
ATOM   548  C CD   . GLU A 1 68  ? -12.99276 14.10279  37.76897  1.000 38.07466  ? 67  GLU A CD   1 
ATOM   549  O OE1  . GLU A 1 68  ? -13.31949 12.91274  37.85926  1.000 32.25249  ? 67  GLU A OE1  1 
ATOM   550  O OE2  . GLU A 1 68  ? -13.76490 15.04468  38.00499  1.000 42.14256  ? 67  GLU A OE2  1 
ATOM   551  N N    . LEU A 1 69  ? -11.46304 15.92345  33.97529  1.000 34.60791  ? 68  LEU A N    1 
ATOM   552  C CA   . LEU A 1 69  ? -11.69641 17.34734  33.62810  1.000 35.37345  ? 68  LEU A CA   1 
ATOM   553  C C    . LEU A 1 69  ? -12.81669 17.46593  32.58735  1.000 28.31492  ? 68  LEU A C    1 
ATOM   554  O O    . LEU A 1 69  ? -13.57287 18.42878  32.66236  1.000 34.05707  ? 68  LEU A O    1 
ATOM   555  C CB   . LEU A 1 69  ? -10.36965 17.93653  33.14468  1.000 32.34793  ? 68  LEU A CB   1 
ATOM   556  C CG   . LEU A 1 69  ? -9.37246  18.28193  34.25038  1.000 40.31360  ? 68  LEU A CG   1 
ATOM   557  C CD1  . LEU A 1 69  ? -7.94155  18.15514  33.75606  1.000 32.78092  ? 68  LEU A CD1  1 
ATOM   558  C CD2  . LEU A 1 69  ? -9.62762  19.67597  34.79420  1.000 42.17742  ? 68  LEU A CD2  1 
ATOM   559  N N    . LEU A 1 70  ? -12.93070 16.49575  31.68654  1.000 37.48931  ? 69  LEU A N    1 
ATOM   560  C CA   . LEU A 1 70  ? -14.00995 16.50335  30.66680  1.000 33.50123  ? 69  LEU A CA   1 
ATOM   561  C C    . LEU A 1 70  ? -15.36475 16.37419  31.36014  1.000 31.26147  ? 69  LEU A C    1 
ATOM   562  O O    . LEU A 1 70  ? -16.25499 17.14495  31.03822  1.000 34.90475  ? 69  LEU A O    1 
ATOM   563  C CB   . LEU A 1 70  ? -13.78294 15.35422  29.68494  1.000 32.08131  ? 69  LEU A CB   1 
ATOM   564  C CG   . LEU A 1 70  ? -14.72322 15.33082  28.48117  1.000 42.29042  ? 69  LEU A CG   1 
ATOM   565  C CD1  . LEU A 1 70  ? -14.65668 16.64270  27.71993  1.000 44.64325  ? 69  LEU A CD1  1 
ATOM   566  C CD2  . LEU A 1 70  ? -14.40320 14.16672  27.56030  1.000 43.72903  ? 69  LEU A CD2  1 
ATOM   567  N N    . ARG A 1 71  ? -15.48234 15.43432  32.29133  1.000 32.46841  ? 70  ARG A N    1 
ATOM   568  C CA   . ARG A 1 71  ? -16.73712 15.29320  33.06766  1.000 33.33289  ? 70  ARG A CA   1 
ATOM   569  C C    . ARG A 1 71  ? -17.05325 16.63425  33.72150  1.000 24.42029  ? 70  ARG A C    1 
ATOM   570  O O    . ARG A 1 71  ? -18.20036 17.06200  33.63270  1.000 39.48464  ? 70  ARG A O    1 
ATOM   571  C CB   . ARG A 1 71  ? -16.61165 14.16540  34.09383  1.000 32.93094  ? 70  ARG A CB   1 
ATOM   572  C CG   . ARG A 1 71  ? -16.29751 12.80536  33.49199  1.000 42.40521  ? 70  ARG A CG   1 
ATOM   573  C CD   . ARG A 1 71  ? -16.35103 11.68053  34.50620  1.000 45.02832  ? 70  ARG A CD   1 
ATOM   574  N NE   . ARG A 1 71  ? -15.63890 10.50260  34.04623  1.000 52.58479  ? 70  ARG A NE   1 
ATOM   575  C CZ   . ARG A 1 71  ? -14.40574 10.16892  34.40700  1.000 53.72998  ? 70  ARG A CZ   1 
ATOM   576  N NH1  . ARG A 1 71  ? -13.73170 10.92720  35.25670  1.000 44.61647  ? 70  ARG A NH1  1 
ATOM   577  N NH2  . ARG A 1 71  ? -13.84963 9.07395   33.92005  1.000 52.95715  ? 70  ARG A NH2  1 
ATOM   578  N N    . GLU A 1 72  ? -16.04724 17.28556  34.29915  1.000 26.81830  ? 71  GLU A N    1 
ATOM   579  C CA   . GLU A 1 72  ? -16.24735 18.59363  34.97197  1.000 33.89123  ? 71  GLU A CA   1 
ATOM   580  C C    . GLU A 1 72  ? -16.74881 19.63535  33.95890  1.000 40.33100  ? 71  GLU A C    1 
ATOM   581  O O    . GLU A 1 72  ? -17.73888 20.30720  34.25202  1.000 35.35875  ? 71  GLU A O    1 
ATOM   582  C CB   . GLU A 1 72  ? -14.95728 19.02702  35.65858  1.000 36.03589  ? 71  GLU A CB   1 
ATOM   583  C CG   . GLU A 1 72  ? -14.58382 18.15930  36.84465  1.000 38.17181  ? 71  GLU A CG   1 
ATOM   584  C CD   . GLU A 1 72  ? -13.31273 18.56169  37.56827  1.000 35.32883  ? 71  GLU A CD   1 
ATOM   585  O OE1  . GLU A 1 72  ? -12.99497 19.75976  37.58899  1.000 40.95576  ? 71  GLU A OE1  1 
ATOM   586  O OE2  . GLU A 1 72  ? -12.64541 17.67093  38.11127  1.000 35.39611  ? 71  GLU A OE2  1 
ATOM   587  N N    . LEU A 1 73  ? -16.10310 19.72328  32.79573  1.000 39.43685  ? 72  LEU A N    1 
ATOM   588  C CA   . LEU A 1 73  ? -16.52655 20.64701  31.71267  1.000 38.47284  ? 72  LEU A CA   1 
ATOM   589  C C    . LEU A 1 73  ? -17.98059 20.36364  31.30407  1.000 31.65206  ? 72  LEU A C    1 
ATOM   590  O O    . LEU A 1 73  ? -18.75481 21.31646  31.20209  1.000 32.99493  ? 72  LEU A O    1 
ATOM   591  C CB   . LEU A 1 73  ? -15.56579 20.45800  30.53948  1.000 35.33745  ? 72  LEU A CB   1 
ATOM   592  C CG   . LEU A 1 73  ? -15.58327 21.53081  29.45630  1.000 44.50722  ? 72  LEU A CG   1 
ATOM   593  C CD1  . LEU A 1 73  ? -15.00542 22.83202  29.98393  1.000 44.10518  ? 72  LEU A CD1  1 
ATOM   594  C CD2  . LEU A 1 73  ? -14.80847 21.06176  28.23719  1.000 42.95840  ? 72  LEU A CD2  1 
ATOM   595  N N    . GLU A 1 74  ? -18.32338 19.09853  31.10037  1.000 30.67603  ? 73  GLU A N    1 
ATOM   596  C CA   . GLU A 1 74  ? -19.70240 18.72517  30.67977  1.000 35.76371  ? 73  GLU A CA   1 
ATOM   597  C C    . GLU A 1 74  ? -20.70626 19.21214  31.72192  1.000 45.58096  ? 73  GLU A C    1 
ATOM   598  O O    . GLU A 1 74  ? -21.74146 19.76186  31.32707  1.000 44.08960  ? 73  GLU A O    1 
ATOM   599  C CB   . GLU A 1 74  ? -19.81014 17.21711  30.46705  1.000 34.45518  ? 73  GLU A CB   1 
ATOM   600  C CG   . GLU A 1 74  ? -18.78626 16.66415  29.49491  1.000 45.88491  ? 73  GLU A CG   1 
ATOM   601  C CD   . GLU A 1 74  ? -18.87100 15.16310  29.28619  1.000 66.24630  ? 73  GLU A CD   1 
ATOM   602  O OE1  . GLU A 1 74  ? -19.78708 14.71978  28.56848  1.000 82.84105  ? 73  GLU A OE1  1 
ATOM   603  O OE2  . GLU A 1 74  ? -18.02572 14.44037  29.84211  1.000 66.64997  ? 73  GLU A OE2  1 
ATOM   604  N N    . GLU A 1 75  ? -20.37892 19.04544  33.00187  1.000 40.68591  ? 74  GLU A N    1 
ATOM   605  C CA   . GLU A 1 75  ? -21.28974 19.43844  34.10102  1.000 31.76817  ? 74  GLU A CA   1 
ATOM   606  C C    . GLU A 1 75  ? -21.49805 20.95340  34.10781  1.000 29.48300  ? 74  GLU A C    1 
ATOM   607  O O    . GLU A 1 75  ? -22.64011 21.37218  34.20900  1.000 46.54279  ? 74  GLU A O    1 
ATOM   608  C CB   . GLU A 1 75  ? -20.68832 18.97379  35.42196  1.000 35.99747  ? 74  GLU A CB   1 
ATOM   609  C CG   . GLU A 1 75  ? -20.46899 17.47885  35.50617  1.000 47.26766  ? 74  GLU A CG   1 
ATOM   610  C CD   . GLU A 1 75  ? -19.50765 17.05424  36.60201  1.000 42.19790  ? 74  GLU A CD   1 
ATOM   611  O OE1  . GLU A 1 75  ? -19.33558 17.81945  37.56284  1.000 46.60390  ? 74  GLU A OE1  1 
ATOM   612  O OE2  . GLU A 1 75  ? -18.93845 15.96034  36.49207  1.000 50.66349  ? 74  GLU A OE2  1 
ATOM   613  N N    . LEU A 1 76  ? -20.42323 21.72560  34.00641  1.000 38.58340  ? 75  LEU A N    1 
ATOM   614  C CA   . LEU A 1 76  ? -20.52453 23.20859  34.05818  1.000 46.69544  ? 75  LEU A CA   1 
ATOM   615  C C    . LEU A 1 76  ? -21.29092 23.72822  32.83627  1.000 41.41228  ? 75  LEU A C    1 
ATOM   616  O O    . LEU A 1 76  ? -22.10107 24.63408  33.00331  1.000 41.40721  ? 75  LEU A O    1 
ATOM   617  C CB   . LEU A 1 76  ? -19.11663 23.80889  34.12174  1.000 40.34925  ? 75  LEU A CB   1 
ATOM   618  C CG   . LEU A 1 76  ? -19.04793 25.32992  34.21446  1.000 50.84834  ? 75  LEU A CG   1 
ATOM   619  C CD1  . LEU A 1 76  ? -20.17883 25.86784  35.07263  1.000 60.82613  ? 75  LEU A CD1  1 
ATOM   620  C CD2  . LEU A 1 76  ? -17.70489 25.76730  34.76606  1.000 68.20735  ? 75  LEU A CD2  1 
ATOM   621  N N    . ILE A 1 77  ? -21.02908 23.15207  31.66831  1.000 35.08921  ? 76  ILE A N    1 
ATOM   622  C CA   . ILE A 1 77  ? -21.75146 23.56970  30.43141  1.000 52.44566  ? 76  ILE A CA   1 
ATOM   623  C C    . ILE A 1 77  ? -23.24035 23.28043  30.63981  1.000 45.56546  ? 76  ILE A C    1 
ATOM   624  O O    . ILE A 1 77  ? -24.04762 24.12920  30.26886  1.000 44.37314  ? 76  ILE A O    1 
ATOM   625  C CB   . ILE A 1 77  ? -21.15762 22.89061  29.17939  1.000 42.99863  ? 76  ILE A CB   1 
ATOM   626  C CG1  . ILE A 1 77  ? -19.76581 23.44384  28.85996  1.000 34.67254  ? 76  ILE A CG1  1 
ATOM   627  C CG2  . ILE A 1 77  ? -22.09793 23.02521  27.99659  1.000 40.65540  ? 76  ILE A CG2  1 
ATOM   628  C CD1  . ILE A 1 77  ? -19.08294 22.75278  27.70892  1.000 43.47480  ? 76  ILE A CD1  1 
ATOM   629  N N    . ARG A 1 78  ? -23.56997 22.14947  31.26509  1.000 49.00781  ? 77  ARG A N    1 
ATOM   630  C CA   . ARG A 1 78  ? -24.98183 21.81824  31.59348  1.000 55.62782  ? 77  ARG A CA   1 
ATOM   631  C C    . ARG A 1 78  ? -25.56982 22.88528  32.52744  1.000 51.92543  ? 77  ARG A C    1 
ATOM   632  O O    . ARG A 1 78  ? -26.71196 23.29700  32.29664  1.000 57.24594  ? 77  ARG A O    1 
ATOM   633  C CB   . ARG A 1 78  ? -25.07638 20.45934  32.28674  1.000 51.22904  ? 77  ARG A CB   1 
ATOM   634  C CG   . ARG A 1 78  ? -25.04335 19.25718  31.36195  1.000 63.98872  ? 77  ARG A CG   1 
ATOM   635  C CD   . ARG A 1 78  ? -25.33190 18.01027  32.17223  1.000 78.46100  ? 77  ARG A CD   1 
ATOM   636  N NE   . ARG A 1 78  ? -25.03982 16.78020  31.45138  1.000 93.18298  ? 77  ARG A NE   1 
ATOM   637  C CZ   . ARG A 1 78  ? -24.09855 15.91046  31.80230  1.000 82.92923  ? 77  ARG A CZ   1 
ATOM   638  N NH1  . ARG A 1 78  ? -23.35235 16.13280  32.86609  1.000 64.91228  ? 77  ARG A NH1  1 
ATOM   639  N NH2  . ARG A 1 78  ? -23.91350 14.82137  31.07945  1.000 95.38431  ? 77  ARG A NH2  1 
ATOM   640  N N    . ARG A 1 79  ? -24.81067 23.31661  33.52518  1.000 39.59893  ? 78  ARG A N    1 
ATOM   641  C CA   . ARG A 1 79  ? -25.31265 24.31568  34.49913  1.000 45.47949  ? 78  ARG A CA   1 
ATOM   642  C C    . ARG A 1 79  ? -25.48509 25.68952  33.83393  1.000 50.86252  ? 78  ARG A C    1 
ATOM   643  O O    . ARG A 1 79  ? -26.38914 26.41441  34.24702  1.000 51.21584  ? 78  ARG A O    1 
ATOM   644  C CB   . ARG A 1 79  ? -24.37238 24.41008  35.69989  1.000 47.77352  ? 78  ARG A CB   1 
ATOM   645  C CG   . ARG A 1 79  ? -24.39391 23.18823  36.60311  1.000 57.84345  ? 78  ARG A CG   1 
ATOM   646  C CD   . ARG A 1 79  ? -23.43067 23.33463  37.76385  1.000 45.82044  ? 78  ARG A CD   1 
ATOM   647  N NE   . ARG A 1 79  ? -22.56340 22.17283  37.87185  1.000 57.71538  ? 78  ARG A NE   1 
ATOM   648  C CZ   . ARG A 1 79  ? -21.23941 22.22011  37.87352  1.000 53.07650  ? 78  ARG A CZ   1 
ATOM   649  N NH1  . ARG A 1 79  ? -20.62167 23.38322  37.78017  1.000 62.97048  ? 78  ARG A NH1  1 
ATOM   650  N NH2  . ARG A 1 79  ? -20.53916 21.10727  37.97155  1.000 43.28724  ? 78  ARG A NH2  1 
ATOM   651  N N    . ILE A 1 80  ? -24.67240 26.02652  32.84068  1.000 43.92186  ? 79  ILE A N    1 
ATOM   652  C CA   . ILE A 1 80  ? -24.75782 27.39140  32.24446  1.000 41.79522  ? 79  ILE A CA   1 
ATOM   653  C C    . ILE A 1 80  ? -25.93307 27.45698  31.26473  1.000 44.56617  ? 79  ILE A C    1 
ATOM   654  O O    . ILE A 1 80  ? -26.03110 26.59281  30.39490  1.000 44.77095  ? 79  ILE A O    1 
ATOM   655  C CB   . ILE A 1 80  ? -23.43207 27.82656  31.59707  1.000 45.04346  ? 79  ILE A CB   1 
ATOM   656  C CG1  . ILE A 1 80  ? -22.33787 28.07197  32.63876  1.000 48.75877  ? 79  ILE A CG1  1 
ATOM   657  C CG2  . ILE A 1 80  ? -23.64653 29.04136  30.70591  1.000 43.82695  ? 79  ILE A CG2  1 
ATOM   658  C CD1  . ILE A 1 80  ? -20.97587 27.58617  32.21352  1.000 51.67243  ? 79  ILE A CD1  1 
ATOM   659  N N    . PRO A 1 81  ? -26.81925 28.45682  31.39576  1.000 40.77978  ? 80  PRO A N    1 
ATOM   660  C CA   . PRO A 1 81  ? -27.97748 28.59343  30.52002  1.000 45.11269  ? 80  PRO A CA   1 
ATOM   661  C C    . PRO A 1 81  ? -27.63092 29.04625  29.09286  1.000 46.21807  ? 80  PRO A C    1 
ATOM   662  O O    . PRO A 1 81  ? -28.04723 30.10310  28.69577  1.000 53.97399  ? 80  PRO A O    1 
ATOM   663  C CB   . PRO A 1 81  ? -28.80253 29.66039  31.24603  1.000 38.61232  ? 80  PRO A CB   1 
ATOM   664  C CG   . PRO A 1 81  ? -27.78553 30.48873  31.98064  1.000 53.65194  ? 80  PRO A CG   1 
ATOM   665  C CD   . PRO A 1 81  ? -26.74621 29.48702  32.42757  1.000 43.52335  ? 80  PRO A CD   1 
ATOM   666  N N    . PHE A 1 82  ? -26.91892 28.20327  28.34883  1.000 44.33608  ? 81  PHE A N    1 
ATOM   667  C CA   . PHE A 1 82  ? -26.51732 28.55211  26.96668  1.000 41.23821  ? 81  PHE A CA   1 
ATOM   668  C C    . PHE A 1 82  ? -27.72355 28.56970  26.02996  1.000 42.18157  ? 81  PHE A C    1 
ATOM   669  O O    . PHE A 1 82  ? -28.75035 27.96654  26.34231  1.000 51.67800  ? 81  PHE A O    1 
ATOM   670  C CB   . PHE A 1 82  ? -25.46924 27.57324  26.43660  1.000 39.37454  ? 81  PHE A CB   1 
ATOM   671  C CG   . PHE A 1 82  ? -24.08514 27.71962  27.01024  1.000 30.64494  ? 81  PHE A CG   1 
ATOM   672  C CD1  . PHE A 1 82  ? -23.30444 28.81873  26.70586  1.000 42.38873  ? 81  PHE A CD1  1 
ATOM   673  C CD2  . PHE A 1 82  ? -23.55874 26.74988  27.84729  1.000 32.62104  ? 81  PHE A CD2  1 
ATOM   674  C CE1  . PHE A 1 82  ? -22.03234 28.95309  27.23454  1.000 36.14112  ? 81  PHE A CE1  1 
ATOM   675  C CE2  . PHE A 1 82  ? -22.28564 26.87823  28.36996  1.000 36.39414  ? 81  PHE A CE2  1 
ATOM   676  C CZ   . PHE A 1 82  ? -21.52494 27.98034  28.06659  1.000 31.52190  ? 81  PHE A CZ   1 
ATOM   677  N N    . SER A 1 83  ? -27.59596 29.26653  24.91081  1.000 40.13720  ? 82  SER A N    1 
ATOM   678  C CA   . SER A 1 83  ? -28.65820 29.25413  23.88106  1.000 51.76216  ? 82  SER A CA   1 
ATOM   679  C C    . SER A 1 83  ? -28.75205 27.85101  23.28833  1.000 53.97293  ? 82  SER A C    1 
ATOM   680  O O    . SER A 1 83  ? -27.77288 27.10823  23.36823  1.000 46.62729  ? 82  SER A O    1 
ATOM   681  C CB   . SER A 1 83  ? -28.36067 30.25401  22.79682  1.000 42.13577  ? 82  SER A CB   1 
ATOM   682  O OG   . SER A 1 83  ? -27.38278 29.75305  21.90367  1.000 47.39566  ? 82  SER A OG   1 
ATOM   683  N N    . GLU A 1 84  ? -29.89712 27.50467  22.70766  1.000 53.44557  ? 83  GLU A N    1 
ATOM   684  C CA   . GLU A 1 84  ? -30.08799 26.16253  22.10094  1.000 60.81280  ? 83  GLU A CA   1 
ATOM   685  C C    . GLU A 1 84  ? -28.98618 25.90357  21.06273  1.000 49.30247  ? 83  GLU A C    1 
ATOM   686  O O    . GLU A 1 84  ? -28.36395 24.84171  21.10876  1.000 45.07579  ? 83  GLU A O    1 
ATOM   687  C CB   . GLU A 1 84  ? -31.49111 26.09313  21.50229  1.000 66.95934  ? 83  GLU A CB   1 
ATOM   688  C CG   . GLU A 1 84  ? -32.58295 26.44108  22.50349  1.000 88.95956  ? 83  GLU A CG   1 
ATOM   689  C CD   . GLU A 1 84  ? -33.13226 27.85695  22.42937  1.000 99.59502  ? 83  GLU A CD   1 
ATOM   690  O OE1  . GLU A 1 84  ? -32.41736 28.79917  22.83104  1.000 89.43276  ? 83  GLU A OE1  1 
ATOM   691  O OE2  . GLU A 1 84  ? -34.28340 28.01464  21.97962  1.000 94.12154  ? 83  GLU A OE2  1 
ATOM   692  N N    . GLU A 1 85  ? -28.73559 26.87347  20.19350  1.000 49.36832  ? 84  GLU A N    1 
ATOM   693  C CA   . GLU A 1 85  ? -27.72581 26.70750  19.12029  1.000 49.00359  ? 84  GLU A CA   1 
ATOM   694  C C    . GLU A 1 85  ? -26.33862 26.46989  19.71900  1.000 56.89290  ? 84  GLU A C    1 
ATOM   695  O O    . GLU A 1 85  ? -25.68752 25.50095  19.30201  1.000 58.30800  ? 84  GLU A O    1 
ATOM   696  C CB   . GLU A 1 85  ? -27.75728 27.91733  18.19108  1.000 40.82412  ? 84  GLU A CB   1 
ATOM   697  N N    . ILE A 1 86  ? -25.90957 27.31214  20.65675  1.000 43.03910  ? 85  ILE A N    1 
ATOM   698  C CA   . ILE A 1 86  ? -24.54740 27.17252  21.24545  1.000 44.35281  ? 85  ILE A CA   1 
ATOM   699  C C    . ILE A 1 86  ? -24.44595 25.82767  21.97566  1.000 39.28190  ? 85  ILE A C    1 
ATOM   700  O O    . ILE A 1 86  ? -23.42685 25.16285  21.80853  1.000 45.93314  ? 85  ILE A O    1 
ATOM   701  C CB   . ILE A 1 86  ? -24.21843 28.36675  22.16216  1.000 40.99157  ? 85  ILE A CB   1 
ATOM   702  C CG1  . ILE A 1 86  ? -24.15589 29.67663  21.37592  1.000 45.27346  ? 85  ILE A CG1  1 
ATOM   703  C CG2  . ILE A 1 86  ? -22.93919 28.11315  22.94190  1.000 44.04552  ? 85  ILE A CG2  1 
ATOM   704  C CD1  . ILE A 1 86  ? -23.06014 29.71967  20.34465  1.000 44.30591  ? 85  ILE A CD1  1 
ATOM   705  N N    . ARG A 1 87  ? -25.46869 25.45759  22.73897  1.000 35.15079  ? 86  ARG A N    1 
ATOM   706  C CA   . ARG A 1 87  ? -25.44424 24.19073  23.51018  1.000 49.46532  ? 86  ARG A CA   1 
ATOM   707  C C    . ARG A 1 87  ? -25.22822 23.01161  22.56334  1.000 32.30090  ? 86  ARG A C    1 
ATOM   708  O O    . ARG A 1 87  ? -24.36899 22.18784  22.84427  1.000 45.68003  ? 86  ARG A O    1 
ATOM   709  C CB   . ARG A 1 87  ? -26.75102 24.00360  24.28653  1.000 40.93230  ? 86  ARG A CB   1 
ATOM   710  C CG   . ARG A 1 87  ? -26.72955 22.80076  25.21873  1.000 46.68410  ? 86  ARG A CG   1 
ATOM   711  C CD   . ARG A 1 87  ? -27.97731 22.63365  26.05606  1.000 47.23305  ? 86  ARG A CD   1 
ATOM   712  N NE   . ARG A 1 87  ? -28.14229 23.66279  27.06992  1.000 66.72953  ? 86  ARG A NE   1 
ATOM   713  C CZ   . ARG A 1 87  ? -27.27311 23.93314  28.03766  1.000 54.11000  ? 86  ARG A CZ   1 
ATOM   714  N NH1  . ARG A 1 87  ? -26.14494 23.24939  28.13951  1.000 59.59073  ? 86  ARG A NH1  1 
ATOM   715  N NH2  . ARG A 1 87  ? -27.53310 24.89324  28.90556  1.000 53.45256  ? 86  ARG A NH2  1 
ATOM   716  N N    . ARG A 1 88  ? -26.00447 22.95926  21.49053  1.000 48.13932  ? 87  ARG A N    1 
ATOM   717  C CA   . ARG A 1 88  ? -25.89248 21.86012  20.50169  1.000 52.61368  ? 87  ARG A CA   1 
ATOM   718  C C    . ARG A 1 88  ? -24.47461 21.83231  19.92736  1.000 43.15419  ? 87  ARG A C    1 
ATOM   719  O O    . ARG A 1 88  ? -23.92241 20.73940  19.79242  1.000 43.48446  ? 87  ARG A O    1 
ATOM   720  C CB   . ARG A 1 88  ? -26.96277 22.04871  19.42792  1.000 49.82067  ? 87  ARG A CB   1 
ATOM   721  C CG   . ARG A 1 88  ? -28.38264 22.05251  19.97625  1.000 60.64670  ? 87  ARG A CG   1 
ATOM   722  C CD   . ARG A 1 88  ? -29.42582 21.70611  18.93656  1.000 71.03449  ? 87  ARG A CD   1 
ATOM   723  N NE   . ARG A 1 88  ? -30.76170 21.77893  19.50287  1.000 66.17514  ? 87  ARG A NE   1 
ATOM   724  C CZ   . ARG A 1 88  ? -31.32233 20.82795  20.23817  1.000 93.36600  ? 87  ARG A CZ   1 
ATOM   725  N NH1  . ARG A 1 88  ? -30.66303 19.71213  20.49521  1.000 89.35766  ? 87  ARG A NH1  1 
ATOM   726  N NH2  . ARG A 1 88  ? -32.54625 20.99477  20.70943  1.000 76.12569  ? 87  ARG A NH2  1 
ATOM   727  N N    . GLU A 1 89  ? -23.90992 23.00138  19.64402  1.000 35.68357  ? 88  GLU A N    1 
ATOM   728  C CA   . GLU A 1 89  ? -22.53406 23.07257  19.10668  1.000 41.49949  ? 88  GLU A CA   1 
ATOM   729  C C    . GLU A 1 89  ? -21.55070 22.52295  20.14454  1.000 45.92118  ? 88  GLU A C    1 
ATOM   730  O O    . GLU A 1 89  ? -20.71761 21.67606  19.78449  1.000 37.79063  ? 88  GLU A O    1 
ATOM   731  C CB   . GLU A 1 89  ? -22.18845 24.51057  18.72535  1.000 48.93674  ? 88  GLU A CB   1 
ATOM   732  C CG   . GLU A 1 89  ? -23.08982 25.08820  17.65846  1.000 50.94351  ? 88  GLU A CG   1 
ATOM   733  C CD   . GLU A 1 89  ? -22.88318 26.57920  17.44415  1.000 66.20994  ? 88  GLU A CD   1 
ATOM   734  O OE1  . GLU A 1 89  ? -21.71629 26.99543  17.33780  1.000 50.80701  ? 88  GLU A OE1  1 
ATOM   735  O OE2  . GLU A 1 89  ? -23.88435 27.30999  17.38927  1.000 73.40489  ? 88  GLU A OE2  1 
ATOM   736  N N    . LEU A 1 90  ? -21.66850 22.96814  21.38749  1.000 30.76006  ? 89  LEU A N    1 
ATOM   737  C CA   . LEU A 1 90  ? -20.73115 22.53852  22.44635  1.000 31.58680  ? 89  LEU A CA   1 
ATOM   738  C C    . LEU A 1 90  ? -20.89078 21.03653  22.70065  1.000 36.48972  ? 89  LEU A C    1 
ATOM   739  O O    . LEU A 1 90  ? -19.88260 20.35777  22.87852  1.000 35.70637  ? 89  LEU A O    1 
ATOM   740  C CB   . LEU A 1 90  ? -21.03403 23.36168  23.69927  1.000 30.26720  ? 89  LEU A CB   1 
ATOM   741  C CG   . LEU A 1 90  ? -20.85237 24.87169  23.57497  1.000 31.64328  ? 89  LEU A CG   1 
ATOM   742  C CD1  . LEU A 1 90  ? -21.45123 25.58578  24.77299  1.000 40.71266  ? 89  LEU A CD1  1 
ATOM   743  C CD2  . LEU A 1 90  ? -19.38348 25.22897  23.42156  1.000 28.57289  ? 89  LEU A CD2  1 
ATOM   744  N N    . GLU A 1 91  ? -22.12569 20.55127  22.68402  1.000 33.80023  ? 90  GLU A N    1 
ATOM   745  C CA   . GLU A 1 91  ? -22.40132 19.12227  22.97634  1.000 45.57360  ? 90  GLU A CA   1 
ATOM   746  C C    . GLU A 1 91  ? -21.83840 18.22919  21.85836  1.000 44.16295  ? 90  GLU A C    1 
ATOM   747  O O    . GLU A 1 91  ? -21.28611 17.17336  22.17741  1.000 38.26454  ? 90  GLU A O    1 
ATOM   748  C CB   . GLU A 1 91  ? -23.90423 18.93500  23.19273  1.000 36.22751  ? 90  GLU A CB   1 
ATOM   749  C CG   . GLU A 1 91  ? -24.39602 19.46213  24.52476  1.000 46.94571  ? 90  GLU A CG   1 
ATOM   750  C CD   . GLU A 1 91  ? -25.89695 19.34885  24.71513  1.000 57.30522  ? 90  GLU A CD   1 
ATOM   751  O OE1  . GLU A 1 91  ? -26.60214 19.11553  23.71734  1.000 61.67907  ? 90  GLU A OE1  1 
ATOM   752  O OE2  . GLU A 1 91  ? -26.36071 19.49295  25.86322  1.000 64.21628  ? 90  GLU A OE2  1 
ATOM   753  N N    . GLU A 1 92  ? -21.96679 18.66295  20.60732  1.000 35.36790  ? 91  GLU A N    1 
ATOM   754  C CA   . GLU A 1 92  ? -21.39890 17.88287  19.48332  1.000 41.84523  ? 91  GLU A CA   1 
ATOM   755  C C    . GLU A 1 92  ? -19.89681 17.72122  19.71099  1.000 41.66504  ? 91  GLU A C    1 
ATOM   756  O O    . GLU A 1 92  ? -19.40062 16.60429  19.55706  1.000 34.11687  ? 91  GLU A O    1 
ATOM   757  C CB   . GLU A 1 92  ? -21.71636 18.56457  18.15327  1.000 43.85878  ? 91  GLU A CB   1 
ATOM   758  C CG   . GLU A 1 92  ? -21.16449 17.81948  16.95627  1.000 50.79571  ? 91  GLU A CG   1 
ATOM   759  C CD   . GLU A 1 92  ? -20.07682 18.56557  16.20888  1.000 59.46726  ? 91  GLU A CD   1 
ATOM   760  O OE1  . GLU A 1 92  ? -20.14409 19.80555  16.16468  1.000 83.46744  ? 91  GLU A OE1  1 
ATOM   761  O OE2  . GLU A 1 92  ? -19.16781 17.90566  15.67478  1.000 69.84128  ? 91  GLU A OE2  1 
ATOM   762  N N    . ILE A 1 93  ? -19.22394 18.80742  20.08564  1.000 32.93647  ? 92  ILE A N    1 
ATOM   763  C CA   . ILE A 1 93  ? -17.74789 18.77876  20.28529  1.000 35.99285  ? 92  ILE A CA   1 
ATOM   764  C C    . ILE A 1 93  ? -17.39142 17.87204  21.46836  1.000 36.56044  ? 92  ILE A C    1 
ATOM   765  O O    . ILE A 1 93  ? -16.43229 17.10822  21.34727  1.000 38.72286  ? 92  ILE A O    1 
ATOM   766  C CB   . ILE A 1 93  ? -17.19415 20.20790  20.44591  1.000 32.05190  ? 92  ILE A CB   1 
ATOM   767  C CG1  . ILE A 1 93  ? -17.45162 21.05363  19.19782  1.000 38.24206  ? 92  ILE A CG1  1 
ATOM   768  C CG2  . ILE A 1 93  ? -15.72205 20.17927  20.81556  1.000 27.65925  ? 92  ILE A CG2  1 
ATOM   769  C CD1  . ILE A 1 93  ? -16.84989 22.43077  19.25844  1.000 40.50917  ? 92  ILE A CD1  1 
ATOM   770  N N    . LEU A 1 94  ? -18.16018 17.95507  22.55353  1.000 36.30857  ? 93  LEU A N    1 
ATOM   771  C CA   . LEU A 1 94  ? -17.87173 17.15834  23.76960  1.000 33.37557  ? 93  LEU A CA   1 
ATOM   772  C C    . LEU A 1 94  ? -18.00749 15.66626  23.45790  1.000 28.41324  ? 93  LEU A C    1 
ATOM   773  O O    . LEU A 1 94  ? -17.16522 14.89051  23.90483  1.000 34.37970  ? 93  LEU A O    1 
ATOM   774  C CB   . LEU A 1 94  ? -18.84155 17.59334  24.86876  1.000 36.12781  ? 93  LEU A CB   1 
ATOM   775  C CG   . LEU A 1 94  ? -18.70173 19.03145  25.35947  1.000 41.27779  ? 93  LEU A CG   1 
ATOM   776  C CD1  . LEU A 1 94  ? -19.92863 19.45133  26.14969  1.000 44.21570  ? 93  LEU A CD1  1 
ATOM   777  C CD2  . LEU A 1 94  ? -17.44657 19.19686  26.19715  1.000 43.86640  ? 93  LEU A CD2  1 
ATOM   778  N N    . ARG A 1 95  ? -19.02460 15.30292  22.68920  1.000 29.42126  ? 94  ARG A N    1 
ATOM   779  C CA   . ARG A 1 95  ? -19.21840 13.88781  22.29849  1.000 39.38408  ? 94  ARG A CA   1 
ATOM   780  C C    . ARG A 1 95  ? -18.01250 13.41292  21.47729  1.000 38.57894  ? 94  ARG A C    1 
ATOM   781  O O    . ARG A 1 95  ? -17.52421 12.31806  21.74936  1.000 36.09163  ? 94  ARG A O    1 
ATOM   782  C CB   . ARG A 1 95  ? -20.53655 13.74040  21.53983  1.000 45.78367  ? 94  ARG A CB   1 
ATOM   783  C CG   . ARG A 1 95  ? -21.77433 13.71630  22.42413  1.000 50.72368  ? 94  ARG A CG   1 
ATOM   784  C CD   . ARG A 1 95  ? -23.03449 13.54290  21.60146  1.000 51.69311  ? 94  ARG A CD   1 
ATOM   785  N NE   . ARG A 1 95  ? -23.97967 14.62974  21.80550  1.000 62.52601  ? 94  ARG A NE   1 
ATOM   786  C CZ   . ARG A 1 95  ? -24.33807 15.49750  20.86943  1.000 50.06158  ? 94  ARG A CZ   1 
ATOM   787  N NH1  . ARG A 1 95  ? -23.83234 15.40139  19.65233  1.000 57.66986  ? 94  ARG A NH1  1 
ATOM   788  N NH2  . ARG A 1 95  ? -25.20120 16.45137  21.14747  1.000 66.27754  ? 94  ARG A NH2  1 
ATOM   789  N N    . ARG A 1 96  ? -17.54989 14.23485  20.53504  1.000 30.92155  ? 95  ARG A N    1 
ATOM   790  C CA   . ARG A 1 96  ? -16.36001 13.87195  19.72082  1.000 28.96826  ? 95  ARG A CA   1 
ATOM   791  C C    . ARG A 1 96  ? -15.13975 13.68936  20.63656  1.000 31.23393  ? 95  ARG A C    1 
ATOM   792  O O    . ARG A 1 96  ? -14.36262 12.76548  20.40653  1.000 31.34245  ? 95  ARG A O    1 
ATOM   793  C CB   . ARG A 1 96  ? -16.12449 14.91381  18.62458  1.000 27.81927  ? 95  ARG A CB   1 
ATOM   794  C CG   . ARG A 1 96  ? -15.02164 14.53987  17.64738  1.000 42.27839  ? 95  ARG A CG   1 
ATOM   795  C CD   . ARG A 1 96  ? -15.08645 13.09278  17.20465  1.000 39.00197  ? 95  ARG A CD   1 
ATOM   796  N NE   . ARG A 1 96  ? -14.06262 12.77882  16.22046  1.000 60.42498  ? 95  ARG A NE   1 
ATOM   797  C CZ   . ARG A 1 96  ? -13.68945 11.55183  15.88058  1.000 74.62404  ? 95  ARG A CZ   1 
ATOM   798  N NH1  . ARG A 1 96  ? -14.25309 10.49882  16.44790  1.000 61.43399  ? 95  ARG A NH1  1 
ATOM   799  N NH2  . ARG A 1 96  ? -12.74263 11.37887  14.97639  1.000 71.80043  ? 95  ARG A NH2  1 
ATOM   800  N N    . LEU A 1 97  ? -15.00269 14.54157  21.64138  1.000 25.83415  ? 96  LEU A N    1 
ATOM   801  C CA   . LEU A 1 97  ? -13.85645 14.45797  22.57512  1.000 37.19386  ? 96  LEU A CA   1 
ATOM   802  C C    . LEU A 1 97  ? -13.95099 13.15909  23.38837  1.000 36.69439  ? 96  LEU A C    1 
ATOM   803  O O    . LEU A 1 97  ? -12.92081 12.51133  23.56723  1.000 31.21873  ? 96  LEU A O    1 
ATOM   804  C CB   . LEU A 1 97  ? -13.84749 15.69313  23.48290  1.000 29.10803  ? 96  LEU A CB   1 
ATOM   805  C CG   . LEU A 1 97  ? -13.38692 16.99811  22.83456  1.000 34.52416  ? 96  LEU A CG   1 
ATOM   806  C CD1  . LEU A 1 97  ? -13.73995 18.18519  23.70644  1.000 31.89306  ? 96  LEU A CD1  1 
ATOM   807  C CD2  . LEU A 1 97  ? -11.89398 16.96937  22.55621  1.000 29.45816  ? 96  LEU A CD2  1 
ATOM   808  N N    . LYS A 1 98  ? -15.14981 12.81792  23.83871  1.000 31.65758  ? 97  LYS A N    1 
ATOM   809  C CA   . LYS A 1 98  ? -15.34837 11.56001  24.59798  1.000 38.48903  ? 97  LYS A CA   1 
ATOM   810  C C    . LYS A 1 98  ? -14.94933 10.36594  23.72209  1.000 32.16806  ? 97  LYS A C    1 
ATOM   811  O O    . LYS A 1 98  ? -14.25503 9.48317   24.22308  1.000 32.81997  ? 97  LYS A O    1 
ATOM   812  C CB   . LYS A 1 98  ? -16.79324 11.48580  25.08234  1.000 30.83889  ? 97  LYS A CB   1 
ATOM   813  C CG   . LYS A 1 98  ? -16.99277 10.72098  26.38452  1.000 53.39608  ? 97  LYS A CG   1 
ATOM   814  C CD   . LYS A 1 98  ? -18.23759 9.86173   26.39896  1.000 58.00623  ? 97  LYS A CD   1 
ATOM   815  C CE   . LYS A 1 98  ? -19.50980 10.65843  26.19913  1.000 61.80516  ? 97  LYS A CE   1 
ATOM   816  N NZ   . LYS A 1 98  ? -20.57378 9.84110   25.56852  1.000 59.60292  ? 97  LYS A NZ   1 
ATOM   817  N N    . GLU A 1 99  ? -15.33764 10.37964  22.45418  1.000 32.36338  ? 98  GLU A N    1 
ATOM   818  C CA   . GLU A 1 99  ? -14.96564 9.29855   21.50828  1.000 32.07909  ? 98  GLU A CA   1 
ATOM   819  C C    . GLU A 1 99  ? -13.44265 9.20785   21.39393  1.000 28.23514  ? 98  GLU A C    1 
ATOM   820  O O    . GLU A 1 99  ? -12.91239 8.11298   21.53000  1.000 34.66695  ? 98  GLU A O    1 
ATOM   821  C CB   . GLU A 1 99  ? -15.63201 9.55218   20.16340  1.000 30.40967  ? 98  GLU A CB   1 
ATOM   822  C CG   . GLU A 1 99  ? -17.14300 9.61088   20.25375  1.000 44.26780  ? 98  GLU A CG   1 
ATOM   823  C CD   . GLU A 1 99  ? -17.86436 9.81550   18.93188  1.000 72.68957  ? 98  GLU A CD   1 
ATOM   824  O OE1  . GLU A 1 99  ? -17.19667 10.18447  17.94466  1.000 65.86387  ? 98  GLU A OE1  1 
ATOM   825  O OE2  . GLU A 1 99  ? -19.09332 9.60524   18.89621  1.000 69.00251  ? 98  GLU A OE2  1 
ATOM   826  N N    . LEU A 1 100 ? -12.77593 10.33795  21.19958  1.000 28.47497  ? 99  LEU A N    1 
ATOM   827  C CA   . LEU A 1 100 ? -11.29997 10.36423  21.03322  1.000 29.81328  ? 99  LEU A CA   1 
ATOM   828  C C    . LEU A 1 100 ? -10.57357 9.87260   22.29513  1.000 28.15975  ? 99  LEU A C    1 
ATOM   829  O O    . LEU A 1 100 ? -9.59346  9.15377   22.14403  1.000 29.99528  ? 99  LEU A O    1 
ATOM   830  C CB   . LEU A 1 100 ? -10.89435 11.79225  20.67188  1.000 29.06368  ? 99  LEU A CB   1 
ATOM   831  C CG   . LEU A 1 100 ? -11.31578 12.26692  19.28089  1.000 35.54799  ? 99  LEU A CG   1 
ATOM   832  C CD1  . LEU A 1 100 ? -11.11513 13.76493  19.13558  1.000 26.33640  ? 99  LEU A CD1  1 
ATOM   833  C CD2  . LEU A 1 100 ? -10.54289 11.52489  18.20384  1.000 35.01423  ? 99  LEU A CD2  1 
ATOM   834  N N    . TYR A 1 101 ? -11.03737 10.26271  23.48218  1.000 31.72327  ? 100 TYR A N    1 
ATOM   835  C CA   . TYR A 1 101 ? -10.42597 9.79306   24.74911  1.000 31.60083  ? 100 TYR A CA   1 
ATOM   836  C C    . TYR A 1 101 ? -10.60763 8.27504   24.86442  1.000 21.00697  ? 100 TYR A C    1 
ATOM   837  O O    . TYR A 1 101 ? -9.69537  7.61031   25.34432  1.000 29.24933  ? 100 TYR A O    1 
ATOM   838  C CB   . TYR A 1 101 ? -10.98885 10.58015  25.94011  1.000 30.63428  ? 100 TYR A CB   1 
ATOM   839  C CG   . TYR A 1 101 ? -10.46011 11.98828  26.05274  1.000 32.30079  ? 100 TYR A CG   1 
ATOM   840  C CD1  . TYR A 1 101 ? -9.10117  12.24656  26.05037  1.000 25.42848  ? 100 TYR A CD1  1 
ATOM   841  C CD2  . TYR A 1 101 ? -11.32231 13.06411  26.15176  1.000 39.62141  ? 100 TYR A CD2  1 
ATOM   842  C CE1  . TYR A 1 101 ? -8.61041  13.53667  26.14903  1.000 29.58869  ? 100 TYR A CE1  1 
ATOM   843  C CE2  . TYR A 1 101 ? -10.84956 14.36123  26.25042  1.000 49.44261  ? 100 TYR A CE2  1 
ATOM   844  C CZ   . TYR A 1 101 ? -9.48760  14.59951  26.25305  1.000 37.21730  ? 100 TYR A CZ   1 
ATOM   845  O OH   . TYR A 1 101 ? -9.02384  15.87462  26.35172  1.000 39.19183  ? 100 TYR A OH   1 
ATOM   846  N N    . GLU A 1 102 ? -11.74163 7.76972   24.39678  1.000 26.93303  ? 101 GLU A N    1 
ATOM   847  C CA   . GLU A 1 102 ? -12.00532 6.31467   24.43010  1.000 32.99459  ? 101 GLU A CA   1 
ATOM   848  C C    . GLU A 1 102 ? -11.06741 5.61670   23.44899  1.000 33.58509  ? 101 GLU A C    1 
ATOM   849  O O    . GLU A 1 102 ? -10.53111 4.56387   23.79705  1.000 31.49347  ? 101 GLU A O    1 
ATOM   850  C CB   . GLU A 1 102 ? -13.47335 6.06531   24.09949  1.000 40.16741  ? 101 GLU A CB   1 
ATOM   851  C CG   . GLU A 1 102 ? -14.42723 6.64429   25.12262  1.000 58.80259  ? 101 GLU A CG   1 
ATOM   852  C CD   . GLU A 1 102 ? -15.88834 6.68492   24.70296  1.000 71.51290  ? 101 GLU A CD   1 
ATOM   853  O OE1  . GLU A 1 102 ? -16.17270 7.15666   23.58394  1.000 76.78462  ? 101 GLU A OE1  1 
ATOM   854  O OE2  . GLU A 1 102 ? -16.73806 6.24988   25.49924  1.000 63.48808  ? 101 GLU A OE2  1 
ATOM   855  N N    . GLU A 1 103 ? -10.88682 6.21353   22.27285  1.000 31.31990  ? 102 GLU A N    1 
ATOM   856  C CA   . GLU A 1 103 ? -9.95994  5.65154   21.26172  1.000 31.16270  ? 102 GLU A CA   1 
ATOM   857  C C    . GLU A 1 103 ? -8.53580  5.60294   21.83039  1.000 29.67545  ? 102 GLU A C    1 
ATOM   858  O O    . GLU A 1 103 ? -7.86664  4.59504   21.63341  1.000 29.37439  ? 102 GLU A O    1 
ATOM   859  C CB   . GLU A 1 103 ? -10.01042 6.47431   19.97859  1.000 31.30179  ? 102 GLU A CB   1 
ATOM   860  C CG   . GLU A 1 103 ? -11.38159 6.58792   19.35090  1.000 41.13493  ? 102 GLU A CG   1 
ATOM   861  C CD   . GLU A 1 103 ? -11.34006 7.33469   18.03176  1.000 53.98974  ? 102 GLU A CD   1 
ATOM   862  O OE1  . GLU A 1 103 ? -10.26821 7.34581   17.40350  1.000 38.10736  ? 102 GLU A OE1  1 
ATOM   863  O OE2  . GLU A 1 103 ? -12.37027 7.91141   17.64390  1.000 55.21537  ? 102 GLU A OE2  1 
ATOM   864  N N    . ALA A 1 104 ? -8.11385  6.65615   22.52211  1.000 22.62489  ? 103 ALA A N    1 
ATOM   865  C CA   . ALA A 1 104 ? -6.76172  6.71153   23.12078  1.000 26.46953  ? 103 ALA A CA   1 
ATOM   866  C C    . ALA A 1 104 ? -6.58424  5.60175   24.15793  1.000 23.48071  ? 103 ALA A C    1 
ATOM   867  O O    . ALA A 1 104 ? -5.51111  5.01498   24.19478  1.000 33.32870  ? 103 ALA A O    1 
ATOM   868  C CB   . ALA A 1 104 ? -6.54685  8.06168   23.73449  1.000 27.49102  ? 103 ALA A CB   1 
ATOM   869  N N    . LYS A 1 105 ? -7.60400  5.35568   24.96221  1.000 25.88370  ? 104 LYS A N    1 
ATOM   870  C CA   . LYS A 1 105 ? -7.53353  4.28887   25.98738  1.000 31.04601  ? 104 LYS A CA   1 
ATOM   871  C C    . LYS A 1 105 ? -7.37341  2.92279   25.31558  1.000 25.91285  ? 104 LYS A C    1 
ATOM   872  O O    . LYS A 1 105 ? -6.50816  2.17204   25.73051  1.000 42.04702  ? 104 LYS A O    1 
ATOM   873  C CB   . LYS A 1 105 ? -8.78233  4.32176   26.86768  1.000 36.75127  ? 104 LYS A CB   1 
ATOM   874  C CG   . LYS A 1 105 ? -8.78885  3.30996   28.00285  1.000 37.22622  ? 104 LYS A CG   1 
ATOM   875  C CD   . LYS A 1 105 ? -9.89866  3.54490   28.99908  1.000 49.44193  ? 104 LYS A CD   1 
ATOM   876  C CE   . LYS A 1 105 ? -11.26573 3.20553   28.44346  1.000 73.49854  ? 104 LYS A CE   1 
ATOM   877  N NZ   . LYS A 1 105 ? -12.30949 3.26249   29.49470  1.000 101.12537 ? 104 LYS A NZ   1 
ATOM   878  N N    . ARG A 1 106 ? -8.16660  2.64744   24.29182  1.000 32.57110  ? 105 ARG A N    1 
ATOM   879  C CA   . ARG A 1 106 ? -8.08051  1.36433   23.56302  1.000 31.88734  ? 105 ARG A CA   1 
ATOM   880  C C    . ARG A 1 106 ? -6.71364  1.23450   22.88172  1.000 38.14460  ? 105 ARG A C    1 
ATOM   881  O O    . ARG A 1 106 ? -6.16141  0.14062   22.90678  1.000 35.85516  ? 105 ARG A O    1 
ATOM   882  C CB   . ARG A 1 106 ? -9.24073  1.27892   22.57632  1.000 37.38185  ? 105 ARG A CB   1 
ATOM   883  C CG   . ARG A 1 106 ? -10.60254 1.15276   23.24066  1.000 46.70941  ? 105 ARG A CG   1 
ATOM   884  C CD   . ARG A 1 106 ? -11.68268 0.70036   22.27800  1.000 47.26181  ? 105 ARG A CD   1 
ATOM   885  N NE   . ARG A 1 106 ? -12.16710 1.79112   21.44392  1.000 67.25095  ? 105 ARG A NE   1 
ATOM   886  C CZ   . ARG A 1 106 ? -13.27819 2.47893   21.67407  1.000 61.56182  ? 105 ARG A CZ   1 
ATOM   887  N NH1  . ARG A 1 106 ? -14.03788 2.19595   22.71630  1.000 53.14286  ? 105 ARG A NH1  1 
ATOM   888  N NH2  . ARG A 1 106 ? -13.62758 3.44771   20.85498  1.000 41.42846  ? 105 ARG A NH2  1 
ATOM   889  N N    . LEU A 1 107 ? -6.19300  2.32551   22.32241  1.000 30.90456  ? 106 LEU A N    1 
ATOM   890  C CA   . LEU A 1 107 ? -4.87916  2.28366   21.63710  1.000 28.69425  ? 106 LEU A CA   1 
ATOM   891  C C    . LEU A 1 107 ? -3.78385  1.97307   22.66589  1.000 32.98733  ? 106 LEU A C    1 
ATOM   892  O O    . LEU A 1 107 ? -2.91475  1.14819   22.36583  1.000 26.09562  ? 106 LEU A O    1 
ATOM   893  C CB   . LEU A 1 107 ? -4.64060  3.61458   20.91881  1.000 31.62691  ? 106 LEU A CB   1 
ATOM   894  C CG   . LEU A 1 107 ? -3.51285  3.63864   19.88854  1.000 43.09487  ? 106 LEU A CG   1 
ATOM   895  C CD1  . LEU A 1 107 ? -3.61332  4.88547   19.02735  1.000 48.48284  ? 106 LEU A CD1  1 
ATOM   896  C CD2  . LEU A 1 107 ? -2.15668  3.57704   20.57023  1.000 50.33613  ? 106 LEU A CD2  1 
ATOM   897  N N    . MET A 1 108 ? -3.85770  2.60125   23.83780  1.000 26.61384  ? 107 MET A N    1 
ATOM   898  C CA   . MET A 1 108 ? -2.84940  2.37865   24.89960  1.000 29.43378  ? 107 MET A CA   1 
ATOM   899  C C    . MET A 1 108 ? -2.93498  0.92772   25.38387  1.000 34.48396  ? 107 MET A C    1 
ATOM   900  O O    . MET A 1 108 ? -1.88380  0.35598   25.65772  1.000 38.05372  ? 107 MET A O    1 
ATOM   901  C CB   . MET A 1 108 ? -3.05432  3.34981   26.06248  1.000 37.25151  ? 107 MET A CB   1 
ATOM   902  C CG   . MET A 1 108 ? -2.26362  4.63595   25.92507  1.000 51.33809  ? 107 MET A CG   1 
ATOM   903  S SD   . MET A 1 108 ? -2.47453  5.77815   27.31392  1.000 44.49127  ? 107 MET A SD   1 
ATOM   904  C CE   . MET A 1 108 ? -4.22363  6.12876   27.17827  1.000 39.89706  ? 107 MET A CE   1 
ATOM   905  N N    . GLU A 1 109 ? -4.13885  0.36348   25.45026  1.000 28.61414  ? 108 GLU A N    1 
ATOM   906  C CA   . GLU A 1 109 ? -4.30247  -1.06549  25.82555  1.000 38.17819  ? 108 GLU A CA   1 
ATOM   907  C C    . GLU A 1 109 ? -3.59153  -1.94452  24.79753  1.000 39.53300  ? 108 GLU A C    1 
ATOM   908  O O    . GLU A 1 109 ? -2.86125  -2.84730  25.20152  1.000 40.13626  ? 108 GLU A O    1 
ATOM   909  C CB   . GLU A 1 109 ? -5.77637  -1.46579  25.87497  1.000 32.27119  ? 108 GLU A CB   1 
ATOM   910  C CG   . GLU A 1 109 ? -6.62133  -0.60780  26.80002  1.000 58.54692  ? 108 GLU A CG   1 
ATOM   911  C CD   . GLU A 1 109 ? -8.12535  -0.72815  26.60640  1.000 68.71600  ? 108 GLU A CD   1 
ATOM   912  O OE1  . GLU A 1 109 ? -8.55250  -1.20642  25.53859  1.000 70.61464  ? 108 GLU A OE1  1 
ATOM   913  O OE2  . GLU A 1 109 ? -8.86921  -0.34414  27.53051  1.000 61.81411  ? 108 GLU A OE2  1 
ATOM   914  N N    . LYS A 1 110 ? -3.80089  -1.66279  23.51553  1.000 39.39349  ? 109 LYS A N    1 
ATOM   915  C CA   . LYS A 1 110 ? -3.12799  -2.44384  22.44551  1.000 36.25175  ? 109 LYS A CA   1 
ATOM   916  C C    . LYS A 1 110 ? -1.61498  -2.28650  22.59212  1.000 31.81389  ? 109 LYS A C    1 
ATOM   917  O O    . LYS A 1 110 ? -0.91081  -3.28138  22.44413  1.000 32.74768  ? 109 LYS A O    1 
ATOM   918  C CB   . LYS A 1 110 ? -3.60640  -2.01818  21.06055  1.000 41.93032  ? 109 LYS A CB   1 
ATOM   919  C CG   . LYS A 1 110 ? -5.05642  -2.33454  20.73095  1.000 52.30407  ? 109 LYS A CG   1 
ATOM   920  C CD   . LYS A 1 110 ? -5.46484  -1.86586  19.35796  1.000 59.11498  ? 109 LYS A CD   1 
ATOM   921  C CE   . LYS A 1 110 ? -6.90285  -2.20421  19.02437  1.000 86.44593  ? 109 LYS A CE   1 
ATOM   922  N NZ   . LYS A 1 110 ? -7.29327  -1.71453  17.68137  1.000 97.52070  ? 109 LYS A NZ   1 
ATOM   923  N N    . ALA A 1 111 ? -1.15616  -1.07635  22.89980  1.000 31.08890  ? 110 ALA A N    1 
ATOM   924  C CA   . ALA A 1 111 ? 0.29781   -0.84503  22.99541  1.000 32.14497  ? 110 ALA A CA   1 
ATOM   925  C C    . ALA A 1 111 ? 0.85626   -1.64271  24.17542  1.000 31.90944  ? 110 ALA A C    1 
ATOM   926  O O    . ALA A 1 111 ? 1.92735   -2.22851  24.03627  1.000 39.62263  ? 110 ALA A O    1 
ATOM   927  C CB   . ALA A 1 111 ? 0.57655   0.61705   23.13809  1.000 31.65883  ? 110 ALA A CB   1 
ATOM   928  N N    . LYS A 1 112 ? 0.12353   -1.66567  25.28160  1.000 34.99217  ? 111 LYS A N    1 
ATOM   929  C CA   . LYS A 1 112 ? 0.56697   -2.41137  26.48262  1.000 34.95819  ? 111 LYS A CA   1 
ATOM   930  C C    . LYS A 1 112 ? 0.63720   -3.90141  26.15087  1.000 27.50554  ? 111 LYS A C    1 
ATOM   931  O O    . LYS A 1 112 ? 1.62542   -4.54114  26.52174  1.000 39.06862  ? 111 LYS A O    1 
ATOM   932  C CB   . LYS A 1 112 ? -0.35981  -2.13035  27.66779  1.000 36.17545  ? 111 LYS A CB   1 
ATOM   933  C CG   . LYS A 1 112 ? -0.24495  -0.73723  28.26752  1.000 49.49674  ? 111 LYS A CG   1 
ATOM   934  C CD   . LYS A 1 112 ? -0.90065  -0.60812  29.62666  1.000 65.25796  ? 111 LYS A CD   1 
ATOM   935  C CE   . LYS A 1 112 ? -2.36358  -0.99243  29.62007  1.000 56.27705  ? 111 LYS A CE   1 
ATOM   936  N NZ   . LYS A 1 112 ? -3.11847  -0.29440  30.68413  1.000 58.94528  ? 111 LYS A NZ   1 
ATOM   937  N N    . GLU A 1 113 ? -0.37886  -4.40874  25.46820  1.000 32.31457  ? 112 GLU A N    1 
ATOM   938  C CA   . GLU A 1 113 ? -0.39864  -5.84980  25.14445  1.000 35.55269  ? 112 GLU A CA   1 
ATOM   939  C C    . GLU A 1 113 ? 0.79721   -6.15071  24.24122  1.000 38.66469  ? 112 GLU A C    1 
ATOM   940  O O    . GLU A 1 113 ? 1.45347   -7.16954  24.46624  1.000 40.20256  ? 112 GLU A O    1 
ATOM   941  C CB   . GLU A 1 113 ? -1.72071  -6.24419  24.49484  1.000 36.57335  ? 112 GLU A CB   1 
ATOM   942  C CG   . GLU A 1 113 ? -2.95462  -5.80731  25.25305  1.000 45.10164  ? 112 GLU A CG   1 
ATOM   943  C CD   . GLU A 1 113 ? -4.21181  -5.85972  24.40336  1.000 66.94218  ? 112 GLU A CD   1 
ATOM   944  O OE1  . GLU A 1 113 ? -4.09813  -5.73791  23.16931  1.000 68.55165  ? 112 GLU A OE1  1 
ATOM   945  O OE2  . GLU A 1 113 ? -5.30364  -6.02785  24.97665  1.000 80.93899  ? 112 GLU A OE2  1 
ATOM   946  N N    . LEU A 1 114 ? 1.07380   -5.26282  23.28800  1.000 38.10348  ? 113 LEU A N    1 
ATOM   947  C CA   . LEU A 1 114 ? 2.17662   -5.49576  22.32178  1.000 35.56878  ? 113 LEU A CA   1 
ATOM   948  C C    . LEU A 1 114 ? 3.51580   -5.51436  23.06246  1.000 34.32072  ? 113 LEU A C    1 
ATOM   949  O O    . LEU A 1 114 ? 4.34091   -6.37824  22.76741  1.000 42.01526  ? 113 LEU A O    1 
ATOM   950  C CB   . LEU A 1 114 ? 2.13914   -4.40596  21.24960  1.000 34.95971  ? 113 LEU A CB   1 
ATOM   951  C CG   . LEU A 1 114 ? 3.22090   -4.50692  20.17335  1.000 48.24661  ? 113 LEU A CG   1 
ATOM   952  C CD1  . LEU A 1 114 ? 2.93091   -5.65315  19.22162  1.000 56.77546  ? 113 LEU A CD1  1 
ATOM   953  C CD2  . LEU A 1 114 ? 3.34445   -3.19903  19.40210  1.000 47.46343  ? 113 LEU A CD2  1 
ATOM   954  N N    . THR A 1 115 ? 3.69783   -4.59915  24.00226  1.000 30.78400  ? 114 THR A N    1 
ATOM   955  C CA   . THR A 1 115 ? 4.94901   -4.54176  24.79395  1.000 52.25961  ? 114 THR A CA   1 
ATOM   956  C C    . THR A 1 115 ? 5.08547   -5.82459  25.61714  1.000 46.83604  ? 114 THR A C    1 
ATOM   957  O O    . THR A 1 115 ? 6.18460   -6.37735  25.66798  1.000 45.22731  ? 114 THR A O    1 
ATOM   958  C CB   . THR A 1 115 ? 4.96895   -3.26360  25.64372  1.000 48.64659  ? 114 THR A CB   1 
ATOM   959  O OG1  . THR A 1 115 ? 4.82351   -2.13878  24.78156  1.000 48.62814  ? 114 THR A OG1  1 
ATOM   960  C CG2  . THR A 1 115 ? 6.23311   -3.12920  26.46440  1.000 56.78980  ? 114 THR A CG2  1 
ATOM   961  N N    . LYS A 1 116 ? 3.99071   -6.28371  26.21148  1.000 38.39611  ? 115 LYS A N    1 
ATOM   962  C CA   . LYS A 1 116 ? 4.01115   -7.53356  27.00869  1.000 46.56818  ? 115 LYS A CA   1 
ATOM   963  C C    . LYS A 1 116 ? 4.41918   -8.70064  26.11180  1.000 39.55783  ? 115 LYS A C    1 
ATOM   964  O O    . LYS A 1 116 ? 5.25945   -9.49939  26.52874  1.000 47.49346  ? 115 LYS A O    1 
ATOM   965  C CB   . LYS A 1 116 ? 2.63435   -7.78074  27.62407  1.000 32.07966  ? 115 LYS A CB   1 
ATOM   966  C CG   . LYS A 1 116 ? 2.20840   -6.77565  28.67799  1.000 49.42306  ? 115 LYS A CG   1 
ATOM   967  C CD   . LYS A 1 116 ? 0.83359   -7.04483  29.24137  1.000 78.13186  ? 115 LYS A CD   1 
ATOM   968  C CE   . LYS A 1 116 ? 0.42863   -6.05273  30.30829  1.000 84.53640  ? 115 LYS A CE   1 
ATOM   969  N NZ   . LYS A 1 116 ? -0.93219  -6.32492  30.82366  1.000 115.53233 ? 115 LYS A NZ   1 
ATOM   970  N N    . ARG A 1 117 ? 3.83792   -8.77796  24.92395  1.000 40.46180  ? 116 ARG A N    1 
ATOM   971  C CA   . ARG A 1 117 ? 4.12994   -9.91906  24.02608  1.000 49.81937  ? 116 ARG A CA   1 
ATOM   972  C C    . ARG A 1 117 ? 5.60183   -9.88983  23.60573  1.000 45.14324  ? 116 ARG A C    1 
ATOM   973  O O    . ARG A 1 117 ? 6.20405   -10.96471 23.56977  1.000 45.70102  ? 116 ARG A O    1 
ATOM   974  C CB   . ARG A 1 117 ? 3.19664   -9.88646  22.81730  1.000 43.52613  ? 116 ARG A CB   1 
ATOM   975  C CG   . ARG A 1 117 ? 1.71775   -10.00371 23.15467  1.000 48.27145  ? 116 ARG A CG   1 
ATOM   976  C CD   . ARG A 1 117 ? 0.89344   -9.98210  21.88386  1.000 55.04191  ? 116 ARG A CD   1 
ATOM   977  N NE   . ARG A 1 117 ? -0.53549  -10.02835 22.14121  1.000 68.22069  ? 116 ARG A NE   1 
ATOM   978  C CZ   . ARG A 1 117 ? -1.40878  -9.13561  21.69827  1.000 78.03945  ? 116 ARG A CZ   1 
ATOM   979  N NH1  . ARG A 1 117 ? -1.00017  -8.11066  20.96399  1.000 54.80831  ? 116 ARG A NH1  1 
ATOM   980  N NH2  . ARG A 1 117 ? -2.69068  -9.26983  21.98459  1.000 72.57980  ? 116 ARG A NH2  1 
ATOM   981  N N    . ILE A 1 118 ? 6.15652   -8.71277  23.31439  1.000 40.16226  ? 117 ILE A N    1 
ATOM   982  C CA   . ILE A 1 118 ? 7.55738   -8.62456  22.80404  1.000 44.26254  ? 117 ILE A CA   1 
ATOM   983  C C    . ILE A 1 118 ? 8.54072   -8.98717  23.91587  1.000 38.32445  ? 117 ILE A C    1 
ATOM   984  O O    . ILE A 1 118 ? 9.62674   -9.46200  23.59369  1.000 43.28423  ? 117 ILE A O    1 
ATOM   985  C CB   . ILE A 1 118 ? 7.86095   -7.22960  22.21772  1.000 40.13441  ? 117 ILE A CB   1 
ATOM   986  C CG1  . ILE A 1 118 ? 9.02772   -7.27253  21.22945  1.000 36.43985  ? 117 ILE A CG1  1 
ATOM   987  C CG2  . ILE A 1 118 ? 8.10401   -6.21736  23.32849  1.000 32.31988  ? 117 ILE A CG2  1 
ATOM   988  C CD1  . ILE A 1 118 ? 8.75760   -8.10780  20.00466  1.000 39.45980  ? 117 ILE A CD1  1 
ATOM   989  N N    . LYS A 1 119 ? 8.16397   -8.74803  25.16592  1.000 44.97146  ? 118 LYS A N    1 
ATOM   990  C CA   . LYS A 1 119 ? 9.06230   -9.03764  26.31275  1.000 47.17282  ? 118 LYS A CA   1 
ATOM   991  C C    . LYS A 1 119 ? 9.25364   -10.54958 26.44597  1.000 40.96576  ? 118 LYS A C    1 
ATOM   992  O O    . LYS A 1 119 ? 10.17790  -10.96227 27.14382  1.000 52.47140  ? 118 LYS A O    1 
ATOM   993  C CB   . LYS A 1 119 ? 8.48248   -8.44554  27.59779  1.000 39.08810  ? 118 LYS A CB   1 
ATOM   994  C CG   . LYS A 1 119 ? 8.90826   -7.01540  27.90544  1.000 60.28018  ? 118 LYS A CG   1 
ATOM   995  C CD   . LYS A 1 119 ? 7.91031   -6.26245  28.75754  1.000 50.60146  ? 118 LYS A CD   1 
ATOM   996  C CE   . LYS A 1 119 ? 8.07672   -6.52716  30.23755  1.000 54.38291  ? 118 LYS A CE   1 
ATOM   997  N NZ   . LYS A 1 119 ? 6.79886   -6.38630  30.96783  1.000 64.85117  ? 118 LYS A NZ   1 
ATOM   998  N N    . LYS A 1 120 ? 8.42664   -11.33087 25.76330  1.000 41.58615  ? 119 LYS A N    1 
ATOM   999  C CA   . LYS A 1 120 ? 8.48998   -12.80383 25.89855  1.000 47.34048  ? 119 LYS A CA   1 
ATOM   1000 C C    . LYS A 1 120 ? 9.37485   -13.41884 24.80344  1.000 53.21278  ? 119 LYS A C    1 
ATOM   1001 O O    . LYS A 1 120 ? 9.46209   -14.64683 24.75564  1.000 43.49059  ? 119 LYS A O    1 
ATOM   1002 C CB   . LYS A 1 120 ? 7.05508   -13.33113 25.87598  1.000 55.22682  ? 119 LYS A CB   1 
ATOM   1003 C CG   . LYS A 1 120 ? 6.11519   -12.68515 26.88009  1.000 40.66607  ? 119 LYS A CG   1 
ATOM   1004 C CD   . LYS A 1 120 ? 4.66418   -12.97250 26.59549  1.000 46.01597  ? 119 LYS A CD   1 
ATOM   1005 C CE   . LYS A 1 120 ? 3.78143   -12.78047 27.80866  1.000 45.83395  ? 119 LYS A CE   1 
ATOM   1006 N NZ   . LYS A 1 120 ? 4.52778   -13.02110 29.06653  1.000 51.14733  ? 119 LYS A NZ   1 
ATOM   1007 N N    . ILE A 1 121 ? 10.04048  -12.59984 23.98714  1.000 49.62463  ? 120 ILE A N    1 
ATOM   1008 C CA   . ILE A 1 121 ? 10.80832  -13.14489 22.83405  1.000 59.90347  ? 120 ILE A CA   1 
ATOM   1009 C C    . ILE A 1 121 ? 12.29128  -12.80056 22.96764  1.000 59.47666  ? 120 ILE A C    1 
ATOM   1010 O O    . ILE A 1 121 ? 12.61529  -11.91935 23.76541  1.000 47.51472  ? 120 ILE A O    1 
ATOM   1011 C CB   . ILE A 1 121 ? 10.21590  -12.60524 21.51610  1.000 53.76289  ? 120 ILE A CB   1 
ATOM   1012 C CG1  . ILE A 1 121 ? 8.73193   -12.95257 21.37951  1.000 48.85059  ? 120 ILE A CG1  1 
ATOM   1013 C CG2  . ILE A 1 121 ? 11.01070  -13.07029 20.30699  1.000 69.16408  ? 120 ILE A CG2  1 
ATOM   1014 C CD1  . ILE A 1 121 ? 8.48515   -14.39468 21.03483  1.000 44.40227  ? 120 ILE A CD1  1 
ATOM   1015 N N    . ASP A 1 122 ? 13.15026  -13.51351 22.24056  1.000 59.64576  ? 121 ASP A N    1 
ATOM   1016 C CA   . ASP A 1 122 ? 14.59818  -13.18121 22.21916  1.000 73.80592  ? 121 ASP A CA   1 
ATOM   1017 C C    . ASP A 1 122 ? 14.79071  -12.00934 21.26191  1.000 72.88392  ? 121 ASP A C    1 
ATOM   1018 O O    . ASP A 1 122 ? 14.50346  -12.17761 20.06400  1.000 78.53844  ? 121 ASP A O    1 
ATOM   1019 C CB   . ASP A 1 122 ? 15.45434  -14.38010 21.82716  1.000 73.28068  ? 121 ASP A CB   1 
ATOM   1020 C CG   . ASP A 1 122 ? 16.92537  -14.17974 22.13878  1.000 103.05851 ? 121 ASP A CG   1 
ATOM   1021 O OD1  . ASP A 1 122 ? 17.49205  -13.18471 21.65147  1.000 94.35844  ? 121 ASP A OD1  1 
ATOM   1022 O OD2  . ASP A 1 122 ? 17.48772  -15.01750 22.87079  1.000 110.82115 ? 121 ASP A OD2  1 
ATOM   1023 N N    . ASP A 1 125 ? 16.38069  -11.71671 17.24148  1.000 65.78962  ? 124 ASP A N    1 
ATOM   1024 C CA   . ASP A 1 125 ? 15.49249  -12.05309 16.09575  1.000 71.42137  ? 124 ASP A CA   1 
ATOM   1025 C C    . ASP A 1 125 ? 15.07205  -10.75530 15.39662  1.000 72.08327  ? 124 ASP A C    1 
ATOM   1026 O O    . ASP A 1 125 ? 14.34204  -9.97434  16.01366  1.000 67.66705  ? 124 ASP A O    1 
ATOM   1027 C CB   . ASP A 1 125 ? 14.29477  -12.90427 16.52318  1.000 62.81877  ? 124 ASP A CB   1 
ATOM   1028 C CG   . ASP A 1 125 ? 13.53060  -13.47463 15.34346  1.000 64.39597  ? 124 ASP A CG   1 
ATOM   1029 O OD1  . ASP A 1 125 ? 12.73731  -12.73090 14.74452  1.000 78.71150  ? 124 ASP A OD1  1 
ATOM   1030 O OD2  . ASP A 1 125 ? 13.74277  -14.65564 15.02862  1.000 88.88689  ? 124 ASP A OD2  1 
ATOM   1031 N N    . GLU A 1 126 ? 15.50672  -10.55743 14.15148  1.000 64.41098  ? 125 GLU A N    1 
ATOM   1032 C CA   . GLU A 1 126 ? 15.24929  -9.26860  13.46932  1.000 64.72471  ? 125 GLU A CA   1 
ATOM   1033 C C    . GLU A 1 126 ? 13.82915  -9.21899  12.91765  1.000 75.52263  ? 125 GLU A C    1 
ATOM   1034 O O    . GLU A 1 126 ? 13.18796  -8.17210  13.06862  1.000 71.09366  ? 125 GLU A O    1 
ATOM   1035 C CB   . GLU A 1 126 ? 16.24998  -9.07559  12.33005  1.000 72.15198  ? 125 GLU A CB   1 
ATOM   1036 C CG   . GLU A 1 126 ? 17.46390  -8.25827  12.72761  1.000 74.82941  ? 125 GLU A CG   1 
ATOM   1037 C CD   . GLU A 1 126 ? 18.23250  -7.63131  11.57432  1.000 90.16807  ? 125 GLU A CD   1 
ATOM   1038 O OE1  . GLU A 1 126 ? 17.88317  -6.50446  11.17421  1.000 67.33865  ? 125 GLU A OE1  1 
ATOM   1039 O OE2  . GLU A 1 126 ? 19.18151  -8.26920  11.08221  1.000 89.05470  ? 125 GLU A OE2  1 
ATOM   1040 N N    . LYS A 1 127 ? 13.36722  -10.30119 12.29295  1.000 65.36818  ? 126 LYS A N    1 
ATOM   1041 C CA   . LYS A 1 127 ? 12.03606  -10.27658 11.64826  1.000 58.72358  ? 126 LYS A CA   1 
ATOM   1042 C C    . LYS A 1 127 ? 10.97224  -9.94962  12.69446  1.000 58.85177  ? 126 LYS A C    1 
ATOM   1043 O O    . LYS A 1 127 ? 10.08701  -9.14986  12.39553  1.000 64.66914  ? 126 LYS A O    1 
ATOM   1044 C CB   . LYS A 1 127 ? 11.74319  -11.62276 10.99756  1.000 51.06820  ? 126 LYS A CB   1 
ATOM   1045 C CG   . LYS A 1 127 ? 10.31311  -11.81814 10.51494  1.000 67.29347  ? 126 LYS A CG   1 
ATOM   1046 C CD   . LYS A 1 127 ? 10.06726  -13.19929 9.95624   1.000 77.16671  ? 126 LYS A CD   1 
ATOM   1047 C CE   . LYS A 1 127 ? 9.07599   -13.21169 8.81248   1.000 88.52732  ? 126 LYS A CE   1 
ATOM   1048 N NZ   . LYS A 1 127 ? 9.62984   -13.86879 7.60646   1.000 82.09827  ? 126 LYS A NZ   1 
ATOM   1049 N N    . THR A 1 128 ? 11.07665  -10.56239 13.86754  1.000 54.13811  ? 127 THR A N    1 
ATOM   1050 C CA   . THR A 1 128 ? 10.05786  -10.34842 14.92474  1.000 67.34394  ? 127 THR A CA   1 
ATOM   1051 C C    . THR A 1 128 ? 10.11766  -8.88633  15.35848  1.000 47.55138  ? 127 THR A C    1 
ATOM   1052 O O    . THR A 1 128 ? 9.05556   -8.27353  15.46462  1.000 60.50546  ? 127 THR A O    1 
ATOM   1053 C CB   . THR A 1 128 ? 10.23534  -11.35018 16.07288  1.000 59.42080  ? 127 THR A CB   1 
ATOM   1054 O OG1  . THR A 1 128 ? 9.01252   -11.39931 16.80518  1.000 61.20743  ? 127 THR A OG1  1 
ATOM   1055 C CG2  . THR A 1 128 ? 11.38249  -11.00578 16.99954  1.000 62.06867  ? 127 THR A CG2  1 
ATOM   1056 N N    . LEU A 1 129 ? 11.32060  -8.35905  15.55310  1.000 51.68304  ? 128 LEU A N    1 
ATOM   1057 C CA   . LEU A 1 129 ? 11.48242  -6.95994  16.01781  1.000 57.91299  ? 128 LEU A CA   1 
ATOM   1058 C C    . LEU A 1 129 ? 10.93797  -6.00323  14.95578  1.000 52.63965  ? 128 LEU A C    1 
ATOM   1059 O O    . LEU A 1 129 ? 10.40084  -4.96528  15.33872  1.000 66.83833  ? 128 LEU A O    1 
ATOM   1060 C CB   . LEU A 1 129 ? 12.96043  -6.70358  16.28542  1.000 61.70143  ? 128 LEU A CB   1 
ATOM   1061 C CG   . LEU A 1 129 ? 13.39080  -6.81324  17.74333  1.000 66.09918  ? 128 LEU A CG   1 
ATOM   1062 C CD1  . LEU A 1 129 ? 12.82076  -5.66722  18.55927  1.000 67.41735  ? 128 LEU A CD1  1 
ATOM   1063 C CD2  . LEU A 1 129 ? 12.96721  -8.14922  18.33167  1.000 66.56210  ? 128 LEU A CD2  1 
ATOM   1064 N N    . ARG A 1 130 ? 11.05473  -6.35543  13.68081  1.000 50.66012  ? 129 ARG A N    1 
ATOM   1065 C CA   . ARG A 1 130 ? 10.56929  -5.50873  12.56678  1.000 57.98048  ? 129 ARG A CA   1 
ATOM   1066 C C    . ARG A 1 130 ? 9.05029   -5.46904  12.57613  1.000 57.31092  ? 129 ARG A C    1 
ATOM   1067 O O    . ARG A 1 130 ? 8.50106   -4.37015  12.56507  1.000 49.31475  ? 129 ARG A O    1 
ATOM   1068 C CB   . ARG A 1 130 ? 11.00310  -6.10187  11.22778  1.000 59.36004  ? 129 ARG A CB   1 
ATOM   1069 N N    . GLU A 1 131 ? 8.41952   -6.63917  12.54649  1.000 47.16931  ? 130 GLU A N    1 
ATOM   1070 C CA   . GLU A 1 131 ? 6.94455   -6.71247  12.60685  1.000 44.67798  ? 130 GLU A CA   1 
ATOM   1071 C C    . GLU A 1 131 ? 6.48466   -5.87136  13.79381  1.000 34.71968  ? 130 GLU A C    1 
ATOM   1072 O O    . GLU A 1 131 ? 5.56146   -5.10258  13.62590  1.000 54.36807  ? 130 GLU A O    1 
ATOM   1073 C CB   . GLU A 1 131 ? 6.51088   -8.17254  12.71921  1.000 51.54341  ? 130 GLU A CB   1 
ATOM   1074 C CG   . GLU A 1 131 ? 6.78775   -8.99070  11.47129  1.000 58.59646  ? 130 GLU A CG   1 
ATOM   1075 C CD   . GLU A 1 131 ? 6.69411   -10.49769 11.65257  1.000 88.87723  ? 130 GLU A CD   1 
ATOM   1076 O OE1  . GLU A 1 131 ? 7.17646   -11.00141 12.68354  1.000 82.95088  ? 130 GLU A OE1  1 
ATOM   1077 O OE2  . GLU A 1 131 ? 6.14003   -11.16296 10.75782  1.000 78.45109  ? 130 GLU A OE2  1 
ATOM   1078 N N    . TRP A 1 132 ? 7.17595   -5.97702  14.92267  1.000 44.15849  ? 131 TRP A N    1 
ATOM   1079 C CA   . TRP A 1 132 ? 6.77209   -5.24189  16.14764  1.000 54.36880  ? 131 TRP A CA   1 
ATOM   1080 C C    . TRP A 1 132 ? 6.95673   -3.73388  15.94733  1.000 40.75922  ? 131 TRP A C    1 
ATOM   1081 O O    . TRP A 1 132 ? 6.07367   -2.98900  16.34741  1.000 51.42654  ? 131 TRP A O    1 
ATOM   1082 C CB   . TRP A 1 132 ? 7.53249   -5.77552  17.36655  1.000 41.61827  ? 131 TRP A CB   1 
ATOM   1083 C CG   . TRP A 1 132 ? 7.60657   -4.82230  18.51836  1.000 52.80975  ? 131 TRP A CG   1 
ATOM   1084 C CD1  . TRP A 1 132 ? 6.70278   -4.67931  19.53156  1.000 55.80221  ? 131 TRP A CD1  1 
ATOM   1085 C CD2  . TRP A 1 132 ? 8.65744   -3.88304  18.78195  1.000 54.44678  ? 131 TRP A CD2  1 
ATOM   1086 N NE1  . TRP A 1 132 ? 7.11779   -3.71307  20.40229  1.000 48.89714  ? 131 TRP A NE1  1 
ATOM   1087 C CE2  . TRP A 1 132 ? 8.31158   -3.20290  19.97191  1.000 47.39334  ? 131 TRP A CE2  1 
ATOM   1088 C CE3  . TRP A 1 132 ? 9.84922   -3.54690  18.13561  1.000 64.62888  ? 131 TRP A CE3  1 
ATOM   1089 C CZ2  . TRP A 1 132 ? 9.11551   -2.20664  20.51755  1.000 50.15515  ? 131 TRP A CZ2  1 
ATOM   1090 C CZ3  . TRP A 1 132 ? 10.64514  -2.56065  18.67425  1.000 65.99786  ? 131 TRP A CZ3  1 
ATOM   1091 C CH2  . TRP A 1 132 ? 10.27928  -1.90052  19.84822  1.000 61.55194  ? 131 TRP A CH2  1 
ATOM   1092 N N    . TYR A 1 133 ? 8.05450   -3.31476  15.32700  1.000 44.82099  ? 132 TYR A N    1 
ATOM   1093 C CA   . TYR A 1 133 ? 8.29714   -1.87176  15.09169  1.000 46.92857  ? 132 TYR A CA   1 
ATOM   1094 C C    . TYR A 1 133 ? 7.23280   -1.33514  14.13485  1.000 39.04766  ? 132 TYR A C    1 
ATOM   1095 O O    . TYR A 1 133 ? 6.79661   -0.19720  14.30975  1.000 42.18607  ? 132 TYR A O    1 
ATOM   1096 C CB   . TYR A 1 133 ? 9.72097   -1.61255  14.60330  1.000 48.80893  ? 132 TYR A CB   1 
ATOM   1097 C CG   . TYR A 1 133 ? 10.13269  -0.16545  14.64795  1.000 47.76856  ? 132 TYR A CG   1 
ATOM   1098 C CD1  . TYR A 1 133 ? 9.71776   0.65964   15.67891  1.000 55.99269  ? 132 TYR A CD1  1 
ATOM   1099 C CD2  . TYR A 1 133 ? 10.92734  0.38554   13.65766  1.000 50.60119  ? 132 TYR A CD2  1 
ATOM   1100 C CE1  . TYR A 1 133 ? 10.08450  1.99273   15.72659  1.000 44.25721  ? 132 TYR A CE1  1 
ATOM   1101 C CE2  . TYR A 1 133 ? 11.30707  1.71662   13.69334  1.000 42.62104  ? 132 TYR A CE2  1 
ATOM   1102 C CZ   . TYR A 1 133 ? 10.88415  2.52272   14.73430  1.000 48.86923  ? 132 TYR A CZ   1 
ATOM   1103 O OH   . TYR A 1 133 ? 11.24289  3.83580   14.78499  1.000 49.76803  ? 132 TYR A OH   1 
ATOM   1104 N N    . GLU A 1 134 ? 6.82374   -2.14440  13.17008  1.000 41.99301  ? 133 GLU A N    1 
ATOM   1105 C CA   . GLU A 1 134 ? 5.79642   -1.72278  12.18526  1.000 47.64343  ? 133 GLU A CA   1 
ATOM   1106 C C    . GLU A 1 134 ? 4.47553   -1.43293  12.90552  1.000 42.26417  ? 133 GLU A C    1 
ATOM   1107 O O    . GLU A 1 134 ? 3.86325   -0.40211  12.60449  1.000 35.55717  ? 133 GLU A O    1 
ATOM   1108 C CB   . GLU A 1 134 ? 5.63138   -2.79300  11.10848  1.000 38.91164  ? 133 GLU A CB   1 
ATOM   1109 C CG   . GLU A 1 134 ? 4.80001   -2.34438  9.92660   1.000 53.76588  ? 133 GLU A CG   1 
ATOM   1110 C CD   . GLU A 1 134 ? 4.66697   -3.39160  8.83382   1.000 54.38260  ? 133 GLU A CD   1 
ATOM   1111 O OE1  . GLU A 1 134 ? 5.70497   -3.90846  8.39366   1.000 68.28425  ? 133 GLU A OE1  1 
ATOM   1112 O OE2  . GLU A 1 134 ? 3.52893   -3.69190  8.43614   1.000 55.00561  ? 133 GLU A OE2  1 
ATOM   1113 N N    . ILE A 1 135 ? 4.06193   -2.32086  13.80577  1.000 31.71947  ? 134 ILE A N    1 
ATOM   1114 C CA   . ILE A 1 135 ? 2.80807   -2.10398  14.58003  1.000 40.30512  ? 134 ILE A CA   1 
ATOM   1115 C C    . ILE A 1 135 ? 2.96002   -0.86379  15.46478  1.000 25.88335  ? 134 ILE A C    1 
ATOM   1116 O O    . ILE A 1 135 ? 2.01288   -0.09398  15.52987  1.000 36.98059  ? 134 ILE A O    1 
ATOM   1117 C CB   . ILE A 1 135 ? 2.43452   -3.35192  15.39434  1.000 39.65569  ? 134 ILE A CB   1 
ATOM   1118 C CG1  . ILE A 1 135 ? 2.18556   -4.55812  14.49061  1.000 34.66167  ? 134 ILE A CG1  1 
ATOM   1119 C CG2  . ILE A 1 135 ? 1.24568   -3.06500  16.29357  1.000 29.19582  ? 134 ILE A CG2  1 
ATOM   1120 C CD1  . ILE A 1 135 ? 2.80594   -5.83491  14.99169  1.000 46.32283  ? 134 ILE A CD1  1 
ATOM   1121 N N    . VAL A 1 136 ? 4.11414   -0.68745  16.09548  1.000 33.26612  ? 135 VAL A N    1 
ATOM   1122 C CA   . VAL A 1 136 ? 4.32012   0.45376   17.02723  1.000 39.08309  ? 135 VAL A CA   1 
ATOM   1123 C C    . VAL A 1 136 ? 4.27067   1.77061   16.24801  1.000 35.10544  ? 135 VAL A C    1 
ATOM   1124 O O    . VAL A 1 136 ? 3.69759   2.72058   16.76598  1.000 34.53136  ? 135 VAL A O    1 
ATOM   1125 C CB   . VAL A 1 136 ? 5.62534   0.31817   17.83594  1.000 50.79905  ? 135 VAL A CB   1 
ATOM   1126 C CG1  . VAL A 1 136 ? 5.76578   -1.04269  18.49514  1.000 40.56876  ? 135 VAL A CG1  1 
ATOM   1127 C CG2  . VAL A 1 136 ? 6.85808   0.67228   17.02958  1.000 63.65144  ? 135 VAL A CG2  1 
ATOM   1128 N N    . ARG A 1 137 ? 4.84437   1.79552   15.04487  1.000 34.25589  ? 136 ARG A N    1 
ATOM   1129 C CA   . ARG A 1 137 ? 4.85792   3.02738   14.21865  1.000 42.36398  ? 136 ARG A CA   1 
ATOM   1130 C C    . ARG A 1 137 ? 3.41876   3.44003   13.90492  1.000 32.43165  ? 136 ARG A C    1 
ATOM   1131 O O    . ARG A 1 137 ? 3.08256   4.60299   14.07880  1.000 32.86478  ? 136 ARG A O    1 
ATOM   1132 C CB   . ARG A 1 137 ? 5.67066   2.80533   12.94350  1.000 38.57742  ? 136 ARG A CB   1 
ATOM   1133 C CG   . ARG A 1 137 ? 7.16176   2.60667   13.16217  1.000 41.68679  ? 136 ARG A CG   1 
ATOM   1134 C CD   . ARG A 1 137 ? 7.97039   2.95363   11.92892  1.000 36.54964  ? 136 ARG A CD   1 
ATOM   1135 N NE   . ARG A 1 137 ? 7.54326   2.23633   10.73815  1.000 37.50881  ? 136 ARG A NE   1 
ATOM   1136 C CZ   . ARG A 1 137 ? 7.90044   0.99735   10.43528  1.000 43.58890  ? 136 ARG A CZ   1 
ATOM   1137 N NH1  . ARG A 1 137 ? 8.70377   0.32666   11.24421  1.000 49.35939  ? 136 ARG A NH1  1 
ATOM   1138 N NH2  . ARG A 1 137 ? 7.46229   0.43107   9.33248   1.000 42.64240  ? 136 ARG A NH2  1 
ATOM   1139 N N    . GLU A 1 138 ? 2.58987   2.47979   13.51629  1.000 27.75198  ? 137 GLU A N    1 
ATOM   1140 C CA   . GLU A 1 138 ? 1.18972   2.79444   13.15457  1.000 39.18388  ? 137 GLU A CA   1 
ATOM   1141 C C    . GLU A 1 138 ? 0.41291   3.27849   14.38867  1.000 31.54772  ? 137 GLU A C    1 
ATOM   1142 O O    . GLU A 1 138 ? -0.34132  4.23931   14.25868  1.000 35.56393  ? 137 GLU A O    1 
ATOM   1143 C CB   . GLU A 1 138 ? 0.53081   1.59218   12.49293  1.000 33.34774  ? 137 GLU A CB   1 
ATOM   1144 C CG   . GLU A 1 138 ? -0.80541  1.92180   11.85719  1.000 45.94320  ? 137 GLU A CG   1 
ATOM   1145 C CD   . GLU A 1 138 ? -1.97918  1.89372   12.81948  1.000 68.62789  ? 137 GLU A CD   1 
ATOM   1146 O OE1  . GLU A 1 138 ? -1.97278  1.04788   13.73162  1.000 71.79787  ? 137 GLU A OE1  1 
ATOM   1147 O OE2  . GLU A 1 138 ? -2.89339  2.71750   12.65655  1.000 73.20191  ? 137 GLU A OE2  1 
ATOM   1148 N N    . LEU A 1 139 ? 0.59932   2.62573   15.53074  1.000 33.58973  ? 138 LEU A N    1 
ATOM   1149 C CA   . LEU A 1 139 ? -0.09347  3.04280   16.77483  1.000 33.06754  ? 138 LEU A CA   1 
ATOM   1150 C C    . LEU A 1 139 ? 0.33533   4.46396   17.17448  1.000 22.35350  ? 138 LEU A C    1 
ATOM   1151 O O    . LEU A 1 139 ? -0.53877  5.26583   17.46055  1.000 27.03115  ? 138 LEU A O    1 
ATOM   1152 C CB   . LEU A 1 139 ? 0.22500   2.02706   17.87293  1.000 30.17053  ? 138 LEU A CB   1 
ATOM   1153 C CG   . LEU A 1 139 ? -0.25777  0.60092   17.62129  1.000 38.49418  ? 138 LEU A CG   1 
ATOM   1154 C CD1  . LEU A 1 139 ? 0.17169   -0.32480  18.74635  1.000 39.22190  ? 138 LEU A CD1  1 
ATOM   1155 C CD2  . LEU A 1 139 ? -1.76680  0.56357   17.45166  1.000 36.21157  ? 138 LEU A CD2  1 
ATOM   1156 N N    . LEU A 1 140 ? 1.63527   4.73623   17.15712  1.000 32.56191  ? 139 LEU A N    1 
ATOM   1157 C CA   . LEU A 1 140 ? 2.17207   6.08839   17.48376  1.000 42.77702  ? 139 LEU A CA   1 
ATOM   1158 C C    . LEU A 1 140 ? 1.60162   7.13011   16.51271  1.000 38.27993  ? 139 LEU A C    1 
ATOM   1159 O O    . LEU A 1 140 ? 1.31650   8.23413   16.95259  1.000 30.83148  ? 139 LEU A O    1 
ATOM   1160 C CB   . LEU A 1 140 ? 3.69806   6.03570   17.40940  1.000 31.91782  ? 139 LEU A CB   1 
ATOM   1161 C CG   . LEU A 1 140 ? 4.40048   5.31204   18.55136  1.000 44.83128  ? 139 LEU A CG   1 
ATOM   1162 C CD1  . LEU A 1 140 ? 5.90144   5.26131   18.31201  1.000 38.82174  ? 139 LEU A CD1  1 
ATOM   1163 C CD2  . LEU A 1 140 ? 4.09966   5.97421   19.88632  1.000 47.84650  ? 139 LEU A CD2  1 
ATOM   1164 N N    . GLU A 1 141 ? 1.43540   6.74885   15.24582  1.000 31.80469  ? 140 GLU A N    1 
ATOM   1165 C CA   . GLU A 1 141 ? 0.89596   7.67656   14.22578  1.000 32.45115  ? 140 GLU A CA   1 
ATOM   1166 C C    . GLU A 1 141 ? -0.57902  7.93831   14.51709  1.000 25.87271  ? 140 GLU A C    1 
ATOM   1167 O O    . GLU A 1 141 ? -0.98729  9.08621   14.41099  1.000 31.37471  ? 140 GLU A O    1 
ATOM   1168 C CB   . GLU A 1 141 ? 1.07875   7.09836   12.82484  1.000 27.74830  ? 140 GLU A CB   1 
ATOM   1169 C CG   . GLU A 1 141 ? 0.25635   7.81800   11.77391  1.000 32.90215  ? 140 GLU A CG   1 
ATOM   1170 C CD   . GLU A 1 141 ? 0.65801   9.27006   11.59956  1.000 27.45026  ? 140 GLU A CD   1 
ATOM   1171 O OE1  . GLU A 1 141 ? 1.83499   9.57033   11.80523  1.000 27.51166  ? 140 GLU A OE1  1 
ATOM   1172 O OE2  . GLU A 1 141 ? -0.20724  10.08482  11.26263  1.000 34.89465  ? 140 GLU A OE2  1 
ATOM   1173 N N    . ARG A 1 142 ? -1.32372  6.89422   14.87045  1.000 25.71926  ? 141 ARG A N    1 
ATOM   1174 C CA   . ARG A 1 142 ? -2.75167  7.06998   15.23676  1.000 43.99803  ? 141 ARG A CA   1 
ATOM   1175 C C    . ARG A 1 142 ? -2.84555  7.93419   16.50263  1.000 31.36809  ? 141 ARG A C    1 
ATOM   1176 O O    . ARG A 1 142 ? -3.70772  8.81301   16.54368  1.000 32.20963  ? 141 ARG A O    1 
ATOM   1177 C CB   . ARG A 1 142 ? -3.45535  5.71887   15.40816  1.000 31.45288  ? 141 ARG A CB   1 
ATOM   1178 C CG   . ARG A 1 142 ? -4.94932  5.83160   15.65350  1.000 25.92154  ? 141 ARG A CG   1 
ATOM   1179 C CD   . ARG A 1 142 ? -5.58575  6.80730   14.68348  1.000 35.84144  ? 141 ARG A CD   1 
ATOM   1180 N NE   . ARG A 1 142 ? -6.94073  7.16109   15.06974  1.000 29.11021  ? 141 ARG A NE   1 
ATOM   1181 C CZ   . ARG A 1 142 ? -7.61306  8.18686   14.57172  1.000 39.67793  ? 141 ARG A CZ   1 
ATOM   1182 N NH1  . ARG A 1 142 ? -7.05944  8.96182   13.65746  1.000 33.62574  ? 141 ARG A NH1  1 
ATOM   1183 N NH2  . ARG A 1 142 ? -8.84201  8.42868   14.97797  1.000 35.57378  ? 141 ARG A NH2  1 
ATOM   1184 N N    . ALA A 1 143 ? -1.98226  7.68253   17.47647  1.000 22.15904  ? 142 ALA A N    1 
ATOM   1185 C CA   . ALA A 1 143 ? -1.97313  8.47875   18.72233  1.000 35.38062  ? 142 ALA A CA   1 
ATOM   1186 C C    . ALA A 1 143 ? -1.75152  9.95974   18.38302  1.000 31.74168  ? 142 ALA A C    1 
ATOM   1187 O O    . ALA A 1 143 ? -2.49257  10.79968  18.89405  1.000 36.09137  ? 142 ALA A O    1 
ATOM   1188 C CB   . ALA A 1 143 ? -0.90980  7.95814   19.65217  1.000 27.14897  ? 142 ALA A CB   1 
ATOM   1189 N N    . LYS A 1 144 ? -0.78878  10.23779  17.51374  1.000 36.27468  ? 143 LYS A N    1 
ATOM   1190 C CA   . LYS A 1 144 ? -0.49417  11.63378  17.10743  1.000 36.63160  ? 143 LYS A CA   1 
ATOM   1191 C C    . LYS A 1 144 ? -1.73945  12.25441  16.47361  1.000 31.31468  ? 143 LYS A C    1 
ATOM   1192 O O    . LYS A 1 144 ? -2.05760  13.38740  16.81049  1.000 28.95347  ? 143 LYS A O    1 
ATOM   1193 C CB   . LYS A 1 144 ? 0.71261   11.63486  16.17114  1.000 30.49573  ? 143 LYS A CB   1 
ATOM   1194 C CG   . LYS A 1 144 ? 2.05282   11.35326  16.82787  1.000 40.54481  ? 143 LYS A CG   1 
ATOM   1195 C CD   . LYS A 1 144 ? 3.22453   11.80735  15.99451  1.000 42.87911  ? 143 LYS A CD   1 
ATOM   1196 C CE   . LYS A 1 144 ? 3.90759   10.67737  15.25754  1.000 48.37898  ? 143 LYS A CE   1 
ATOM   1197 N NZ   . LYS A 1 144 ? 5.16234   11.13051  14.61516  1.000 59.13501  ? 143 LYS A NZ   1 
ATOM   1198 N N    . GLU A 1 145 ? -2.42549  11.49512  15.63191  1.000 26.37891  ? 144 GLU A N    1 
ATOM   1199 C CA   . GLU A 1 145 ? -3.64875  11.98875  14.97311  1.000 34.06727  ? 144 GLU A CA   1 
ATOM   1200 C C    . GLU A 1 145 ? -4.71157  12.32572  16.03431  1.000 29.21698  ? 144 GLU A C    1 
ATOM   1201 O O    . GLU A 1 145 ? -5.30981  13.39358  15.93527  1.000 29.48012  ? 144 GLU A O    1 
ATOM   1202 C CB   . GLU A 1 145 ? -4.11178  10.94948  13.94541  1.000 30.09905  ? 144 GLU A CB   1 
ATOM   1203 C CG   . GLU A 1 145 ? -3.09697  10.63450  12.86622  1.000 27.92072  ? 144 GLU A CG   1 
ATOM   1204 C CD   . GLU A 1 145 ? -3.47094  9.45227   11.98751  1.000 38.59823  ? 144 GLU A CD   1 
ATOM   1205 O OE1  . GLU A 1 145 ? -4.58680  8.93606   12.13687  1.000 31.76310  ? 144 GLU A OE1  1 
ATOM   1206 O OE2  . GLU A 1 145 ? -2.64606  9.05429   11.15339  1.000 32.19491  ? 144 GLU A OE2  1 
ATOM   1207 N N    . ILE A 1 146 ? -4.90915  11.45185  17.01951  1.000 27.96808  ? 145 ILE A N    1 
ATOM   1208 C CA   . ILE A 1 146 ? -5.92394  11.67283  18.09271  1.000 26.55172  ? 145 ILE A CA   1 
ATOM   1209 C C    . ILE A 1 146 ? -5.57802  12.94203  18.87441  1.000 21.15817  ? 145 ILE A C    1 
ATOM   1210 O O    . ILE A 1 146 ? -6.46415  13.76488  19.05848  1.000 27.80106  ? 145 ILE A O    1 
ATOM   1211 C CB   . ILE A 1 146 ? -6.02447  10.43996  19.00895  1.000 28.06876  ? 145 ILE A CB   1 
ATOM   1212 C CG1  . ILE A 1 146 ? -6.81440  9.31368   18.34034  1.000 29.28140  ? 145 ILE A CG1  1 
ATOM   1213 C CG2  . ILE A 1 146 ? -6.60823  10.81708  20.36202  1.000 28.90455  ? 145 ILE A CG2  1 
ATOM   1214 C CD1  . ILE A 1 146 ? -6.39601  7.92984   18.76248  1.000 34.51991  ? 145 ILE A CD1  1 
ATOM   1215 N N    . ILE A 1 147 ? -4.32095  13.08436  19.27808  1.000 23.61189  ? 146 ILE A N    1 
ATOM   1216 C CA   . ILE A 1 147 ? -3.86501  14.26760  20.06577  1.000 36.10409  ? 146 ILE A CA   1 
ATOM   1217 C C    . ILE A 1 147 ? -4.11247  15.56341  19.27760  1.000 34.11026  ? 146 ILE A C    1 
ATOM   1218 O O    . ILE A 1 147 ? -4.59252  16.51841  19.87255  1.000 25.83790  ? 146 ILE A O    1 
ATOM   1219 C CB   . ILE A 1 147 ? -2.39087  14.07097  20.47245  1.000 35.63228  ? 146 ILE A CB   1 
ATOM   1220 C CG1  . ILE A 1 147 ? -2.23040  12.90518  21.44962  1.000 39.93219  ? 146 ILE A CG1  1 
ATOM   1221 C CG2  . ILE A 1 147 ? -1.80201  15.35819  21.02509  1.000 45.73439  ? 146 ILE A CG2  1 
ATOM   1222 C CD1  . ILE A 1 147 ? -0.80326  12.49351  21.68535  1.000 45.17307  ? 146 ILE A CD1  1 
ATOM   1223 N N    . GLU A 1 148 ? -3.81077  15.56024  17.98153  1.000 34.98581  ? 147 GLU A N    1 
ATOM   1224 C CA   . GLU A 1 148 ? -3.99723  16.75005  17.11337  1.000 29.03296  ? 147 GLU A CA   1 
ATOM   1225 C C    . GLU A 1 148 ? -5.47232  17.13274  17.04265  1.000 25.03801  ? 147 GLU A C    1 
ATOM   1226 O O    . GLU A 1 148 ? -5.76655  18.31869  17.13652  1.000 30.88408  ? 147 GLU A O    1 
ATOM   1227 C CB   . GLU A 1 148 ? -3.50150  16.46091  15.70030  1.000 32.74202  ? 147 GLU A CB   1 
ATOM   1228 C CG   . GLU A 1 148 ? -2.02446  16.14020  15.59600  1.000 36.01142  ? 147 GLU A CG   1 
ATOM   1229 C CD   . GLU A 1 148 ? -1.62663  15.44305  14.30403  1.000 44.31870  ? 147 GLU A CD   1 
ATOM   1230 O OE1  . GLU A 1 148 ? -2.42286  15.46572  13.35722  1.000 32.98731  ? 147 GLU A OE1  1 
ATOM   1231 O OE2  . GLU A 1 148 ? -0.52752  14.88127  14.25287  1.000 33.36320  ? 147 GLU A OE2  1 
ATOM   1232 N N    . GLU A 1 149 ? -6.34916  16.15052  16.86503  1.000 25.11144  ? 148 GLU A N    1 
ATOM   1233 C CA   . GLU A 1 149 ? -7.80524  16.42221  16.78733  1.000 31.60324  ? 148 GLU A CA   1 
ATOM   1234 C C    . GLU A 1 149 ? -8.31702  16.92234  18.14837  1.000 31.19454  ? 148 GLU A C    1 
ATOM   1235 O O    . GLU A 1 149 ? -9.16120  17.82217  18.14841  1.000 27.92908  ? 148 GLU A O    1 
ATOM   1236 C CB   . GLU A 1 149 ? -8.55010  15.18897  16.28472  1.000 19.90599  ? 148 GLU A CB   1 
ATOM   1237 C CG   . GLU A 1 149 ? -10.01422 15.43061  15.99903  1.000 33.37761  ? 148 GLU A CG   1 
ATOM   1238 C CD   . GLU A 1 149 ? -10.71414 14.25935  15.33740  1.000 48.78363  ? 148 GLU A CD   1 
ATOM   1239 O OE1  . GLU A 1 149 ? -10.03800 13.25944  15.03242  1.000 49.73544  ? 148 GLU A OE1  1 
ATOM   1240 O OE2  . GLU A 1 149 ? -11.93021 14.35007  15.12368  1.000 56.99734  ? 148 GLU A OE2  1 
ATOM   1241 N N    . ILE A 1 150 ? -7.80564  16.36164  19.24234  1.000 29.46784  ? 149 ILE A N    1 
ATOM   1242 C CA   . ILE A 1 150 ? -8.19141  16.82380  20.60835  1.000 34.56427  ? 149 ILE A CA   1 
ATOM   1243 C C    . ILE A 1 150 ? -7.76068  18.28991  20.76300  1.000 22.46431  ? 149 ILE A C    1 
ATOM   1244 O O    . ILE A 1 150 ? -8.58174  19.09082  21.19405  1.000 37.06085  ? 149 ILE A O    1 
ATOM   1245 C CB   . ILE A 1 150 ? -7.59696  15.90911  21.69237  1.000 28.06193  ? 149 ILE A CB   1 
ATOM   1246 C CG1  . ILE A 1 150 ? -8.31867  14.56197  21.75878  1.000 28.07605  ? 149 ILE A CG1  1 
ATOM   1247 C CG2  . ILE A 1 150 ? -7.57778  16.60635  23.04325  1.000 36.40255  ? 149 ILE A CG2  1 
ATOM   1248 C CD1  . ILE A 1 150 ? -7.57826  13.51526  22.55079  1.000 32.47432  ? 149 ILE A CD1  1 
ATOM   1249 N N    . GLU A 1 151 ? -6.53084  18.61410  20.37165  1.000 35.73065  ? 150 GLU A N    1 
ATOM   1250 C CA   . GLU A 1 151 ? -6.02011  20.00622  20.44628  1.000 34.10087  ? 150 GLU A CA   1 
ATOM   1251 C C    . GLU A 1 151 ? -6.93749  20.93689  19.64634  1.000 39.03885  ? 150 GLU A C    1 
ATOM   1252 O O    . GLU A 1 151 ? -7.29458  21.99590  20.16624  1.000 34.58734  ? 150 GLU A O    1 
ATOM   1253 C CB   . GLU A 1 151 ? -4.58124  20.06843  19.94293  1.000 38.54509  ? 150 GLU A CB   1 
ATOM   1254 C CG   . GLU A 1 151 ? -3.58588  19.37679  20.85481  1.000 47.51380  ? 150 GLU A CG   1 
ATOM   1255 C CD   . GLU A 1 151 ? -2.13001  19.54502  20.45544  1.000 58.72144  ? 150 GLU A CD   1 
ATOM   1256 O OE1  . GLU A 1 151 ? -1.82225  19.36288  19.26739  1.000 59.86339  ? 150 GLU A OE1  1 
ATOM   1257 O OE2  . GLU A 1 151 ? -1.31086  19.86135  21.33519  1.000 73.87467  ? 150 GLU A OE2  1 
ATOM   1258 N N    . ARG A 1 152 ? -7.32669  20.52860  18.44350  1.000 33.79491  ? 151 ARG A N    1 
ATOM   1259 C CA   . ARG A 1 152 ? -8.18007  21.37927  17.57456  1.000 40.95438  ? 151 ARG A CA   1 
ATOM   1260 C C    . ARG A 1 152 ? -9.56397  21.56609  18.18985  1.000 30.29960  ? 151 ARG A C    1 
ATOM   1261 O O    . ARG A 1 152 ? -10.09021 22.67597  18.12279  1.000 35.15478  ? 151 ARG A O    1 
ATOM   1262 C CB   . ARG A 1 152 ? -8.34827  20.73699  16.19671  1.000 29.34685  ? 151 ARG A CB   1 
ATOM   1263 C CG   . ARG A 1 152 ? -7.13151  20.84409  15.29340  1.000 46.78114  ? 151 ARG A CG   1 
ATOM   1264 C CD   . ARG A 1 152 ? -7.49182  20.66076  13.83052  1.000 42.69612  ? 151 ARG A CD   1 
ATOM   1265 N NE   . ARG A 1 152 ? -8.16862  19.40257  13.56090  1.000 42.24276  ? 151 ARG A NE   1 
ATOM   1266 C CZ   . ARG A 1 152 ? -7.55742  18.23667  13.41096  1.000 40.15532  ? 151 ARG A CZ   1 
ATOM   1267 N NH1  . ARG A 1 152 ? -6.24238  18.15396  13.50266  1.000 34.57507  ? 151 ARG A NH1  1 
ATOM   1268 N NH2  . ARG A 1 152 ? -8.26425  17.14948  13.16931  1.000 33.69915  ? 151 ARG A NH2  1 
ATOM   1269 N N    . LEU A 1 153 ? -10.12262 20.50607  18.74617  1.000 28.96102  ? 152 LEU A N    1 
ATOM   1270 C CA   . LEU A 1 153 ? -11.49850 20.56288  19.29149  1.000 29.97647  ? 152 LEU A CA   1 
ATOM   1271 C C    . LEU A 1 153 ? -11.52137 21.42910  20.55634  1.000 28.36533  ? 152 LEU A C    1 
ATOM   1272 O O    . LEU A 1 153 ? -12.50447 22.13693  20.75746  1.000 31.72833  ? 152 LEU A O    1 
ATOM   1273 C CB   . LEU A 1 153 ? -11.96614 19.12883  19.55185  1.000 28.17562  ? 152 LEU A CB   1 
ATOM   1274 C CG   . LEU A 1 153 ? -12.41027 18.34252  18.32509  1.000 41.93504  ? 152 LEU A CG   1 
ATOM   1275 C CD1  . LEU A 1 153 ? -12.44889 16.85657  18.63036  1.000 48.26722  ? 152 LEU A CD1  1 
ATOM   1276 C CD2  . LEU A 1 153 ? -13.76648 18.82116  17.84033  1.000 38.16547  ? 152 LEU A CD2  1 
ATOM   1277 N N    . LEU A 1 154 ? -10.45817 21.37746  21.35110  1.000 27.24335  ? 153 LEU A N    1 
ATOM   1278 C CA   . LEU A 1 154 ? -10.37505 22.20369  22.57994  1.000 37.52741  ? 153 LEU A CA   1 
ATOM   1279 C C    . LEU A 1 154 ? -10.28345 23.68664  22.18766  1.000 49.96110  ? 153 LEU A C    1 
ATOM   1280 O O    . LEU A 1 154 ? -10.87646 24.51764  22.88565  1.000 35.76058  ? 153 LEU A O    1 
ATOM   1281 C CB   . LEU A 1 154 ? -9.16576  21.74908  23.40373  1.000 30.14615  ? 153 LEU A CB   1 
ATOM   1282 C CG   . LEU A 1 154 ? -9.27132  20.37317  24.06099  1.000 40.09672  ? 153 LEU A CG   1 
ATOM   1283 C CD1  . LEU A 1 154 ? -7.96308  20.00056  24.73575  1.000 23.00936  ? 153 LEU A CD1  1 
ATOM   1284 C CD2  . LEU A 1 154 ? -10.41607 20.33411  25.05927  1.000 28.06203  ? 153 LEU A CD2  1 
ATOM   1285 N N    . ARG A 1 155 ? -9.57377  23.98460  21.09943  1.000 39.78342  ? 154 ARG A N    1 
ATOM   1286 C CA   . ARG A 1 155 ? -9.48518  25.37953  20.61017  1.000 35.11851  ? 154 ARG A CA   1 
ATOM   1287 C C    . ARG A 1 155 ? -10.84840 25.81415  20.07342  1.000 36.69902  ? 154 ARG A C    1 
ATOM   1288 O O    . ARG A 1 155 ? -11.24056 26.94012  20.37732  1.000 40.16521  ? 154 ARG A O    1 
ATOM   1289 C CB   . ARG A 1 155 ? -8.37946  25.51958  19.56488  1.000 43.81649  ? 154 ARG A CB   1 
ATOM   1290 C CG   . ARG A 1 155 ? -7.00639  25.83896  20.13450  1.000 56.27867  ? 154 ARG A CG   1 
ATOM   1291 C CD   . ARG A 1 155 ? -6.07575  26.33096  19.04419  1.000 77.49799  ? 154 ARG A CD   1 
ATOM   1292 N NE   . ARG A 1 155 ? -5.85278  25.31683  18.02232  1.000 65.84186  ? 154 ARG A NE   1 
ATOM   1293 C CZ   . ARG A 1 155 ? -4.89758  24.39604  18.07925  1.000 73.16605  ? 154 ARG A CZ   1 
ATOM   1294 N NH1  . ARG A 1 155 ? -4.06733  24.37039  19.10706  1.000 70.86053  ? 154 ARG A NH1  1 
ATOM   1295 N NH2  . ARG A 1 155 ? -4.77163  23.51189  17.11037  1.000 48.30014  ? 154 ARG A NH2  1 
ATOM   1296 N N    . ARG A 1 156 ? -11.55139 24.94088  19.35274  1.000 32.04175  ? 155 ARG A N    1 
ATOM   1297 C CA   . ARG A 1 156 ? -12.90958 25.28252  18.86200  1.000 36.03196  ? 155 ARG A CA   1 
ATOM   1298 C C    . ARG A 1 156 ? -13.81137 25.66153  20.04115  1.000 42.15900  ? 155 ARG A C    1 
ATOM   1299 O O    . ARG A 1 156 ? -14.56860 26.60935  19.90617  1.000 40.56050  ? 155 ARG A O    1 
ATOM   1300 C CB   . ARG A 1 156 ? -13.52552 24.11325  18.09735  1.000 37.86318  ? 155 ARG A CB   1 
ATOM   1301 C CG   . ARG A 1 156 ? -14.87073 24.42487  17.46262  1.000 51.03992  ? 155 ARG A CG   1 
ATOM   1302 C CD   . ARG A 1 156 ? -15.41364 23.18963  16.77397  1.000 77.58254  ? 155 ARG A CD   1 
ATOM   1303 N NE   . ARG A 1 156 ? -14.57782 22.78761  15.65384  1.000 87.55658  ? 155 ARG A NE   1 
ATOM   1304 C CZ   . ARG A 1 156 ? -14.66122 23.29338  14.42977  1.000 100.16155 ? 155 ARG A CZ   1 
ATOM   1305 N NH1  . ARG A 1 156 ? -15.54848 24.23515  14.16281  1.000 111.66620 ? 155 ARG A NH1  1 
ATOM   1306 N NH2  . ARG A 1 156 ? -13.85536 22.85938  13.47865  1.000 105.33222 ? 155 ARG A NH2  1 
ATOM   1307 N N    . LEU A 1 157 ? -13.72596 24.91974  21.13826  1.000 40.82179  ? 156 LEU A N    1 
ATOM   1308 C CA   . LEU A 1 157 ? -14.59173 25.18477  22.31242  1.000 41.05093  ? 156 LEU A CA   1 
ATOM   1309 C C    . LEU A 1 157 ? -14.27289 26.57793  22.87310  1.000 37.60452  ? 156 LEU A C    1 
ATOM   1310 O O    . LEU A 1 157 ? -15.21400 27.35177  23.06319  1.000 39.88532  ? 156 LEU A O    1 
ATOM   1311 C CB   . LEU A 1 157 ? -14.33826 24.09300  23.35755  1.000 34.01374  ? 156 LEU A CB   1 
ATOM   1312 C CG   . LEU A 1 157 ? -15.02904 22.75282  23.11195  1.000 39.69387  ? 156 LEU A CG   1 
ATOM   1313 C CD1  . LEU A 1 157 ? -14.58358 21.72809  24.14102  1.000 34.47890  ? 156 LEU A CD1  1 
ATOM   1314 C CD2  . LEU A 1 157 ? -16.54107 22.90451  23.13228  1.000 31.55305  ? 156 LEU A CD2  1 
ATOM   1315 N N    . LEU A 1 158 ? -12.99089 26.86324  23.10575  1.000 32.30741  ? 157 LEU A N    1 
ATOM   1316 C CA   . LEU A 1 158 ? -12.56905 28.19141  23.60542  1.000 41.60173  ? 157 LEU A CA   1 
ATOM   1317 C C    . LEU A 1 158 ? -13.11449 29.27314  22.66736  1.000 48.62804  ? 157 LEU A C    1 
ATOM   1318 O O    . LEU A 1 158 ? -13.53559 30.31914  23.16327  1.000 39.59903  ? 157 LEU A O    1 
ATOM   1319 C CB   . LEU A 1 158 ? -11.04303 28.21875  23.70205  1.000 35.41224  ? 157 LEU A CB   1 
ATOM   1320 C CG   . LEU A 1 158 ? -10.45559 27.52108  24.92603  1.000 38.23984  ? 157 LEU A CG   1 
ATOM   1321 C CD1  . LEU A 1 158 ? -8.94960  27.38837  24.79669  1.000 38.42130  ? 157 LEU A CD1  1 
ATOM   1322 C CD2  . LEU A 1 158 ? -10.81644 28.26423  26.20198  1.000 34.58490  ? 157 LEU A CD2  1 
ATOM   1323 N N    . GLU A 1 159 ? -13.16474 28.98290  21.36942  1.000 35.78016  ? 158 GLU A N    1 
ATOM   1324 C CA   . GLU A 1 159 ? -13.63119 29.97363  20.37336  1.000 45.76591  ? 158 GLU A CA   1 
ATOM   1325 C C    . GLU A 1 159 ? -15.15321 30.12932  20.42369  1.000 42.76617  ? 158 GLU A C    1 
ATOM   1326 O O    . GLU A 1 159 ? -15.61644 31.27223  20.43360  1.000 44.92460  ? 158 GLU A O    1 
ATOM   1327 C CB   . GLU A 1 159 ? -13.13943 29.57249  18.98431  1.000 39.98952  ? 158 GLU A CB   1 
ATOM   1328 C CG   . GLU A 1 159 ? -11.62446 29.57878  18.86695  1.000 52.58541  ? 158 GLU A CG   1 
ATOM   1329 C CD   . GLU A 1 159 ? -11.03662 28.90969  17.63192  1.000 65.51173  ? 158 GLU A CD   1 
ATOM   1330 O OE1  . GLU A 1 159 ? -11.68656 28.00946  17.07724  1.000 60.14254  ? 158 GLU A OE1  1 
ATOM   1331 O OE2  . GLU A 1 159 ? -9.92379  29.29785  17.23359  1.000 59.75952  ? 158 GLU A OE2  1 
ATOM   1332 N N    . ILE A 1 160 ? -15.88597 29.02118  20.45506  1.000 39.32271  ? 159 ILE A N    1 
ATOM   1333 C CA   . ILE A 1 160 ? -17.37397 29.06388  20.50541  1.000 47.21885  ? 159 ILE A CA   1 
ATOM   1334 C C    . ILE A 1 160 ? -17.78981 29.79301  21.77938  1.000 44.53654  ? 159 ILE A C    1 
ATOM   1335 O O    . ILE A 1 160 ? -18.80496 30.48180  21.74250  1.000 43.78548  ? 159 ILE A O    1 
ATOM   1336 C CB   . ILE A 1 160 ? -17.97469 27.64775  20.45380  1.000 36.41451  ? 159 ILE A CB   1 
ATOM   1337 C CG1  . ILE A 1 160 ? -17.60084 26.91860  19.16084  1.000 53.31592  ? 159 ILE A CG1  1 
ATOM   1338 C CG2  . ILE A 1 160 ? -19.47864 27.68547  20.65915  1.000 47.75618  ? 159 ILE A CG2  1 
ATOM   1339 C CD1  . ILE A 1 160 ? -18.20959 25.54545  19.04022  1.000 47.92820  ? 159 ILE A CD1  1 
ATOM   1340 N N    . LEU A 1 161 ? -17.01853 29.63936  22.85022  1.000 40.75581  ? 160 LEU A N    1 
ATOM   1341 C CA   . LEU A 1 161 ? -17.37734 30.24151  24.15420  1.000 39.77676  ? 160 LEU A CA   1 
ATOM   1342 C C    . LEU A 1 161 ? -16.92964 31.70661  24.18384  1.000 46.49289  ? 160 LEU A C    1 
ATOM   1343 O O    . LEU A 1 161 ? -17.47060 32.46164  24.98984  1.000 49.65924  ? 160 LEU A O    1 
ATOM   1344 C CB   . LEU A 1 161 ? -16.70791 29.41684  25.25719  1.000 33.77970  ? 160 LEU A CB   1 
ATOM   1345 C CG   . LEU A 1 161 ? -17.23657 27.99276  25.42156  1.000 44.15975  ? 160 LEU A CG   1 
ATOM   1346 C CD1  . LEU A 1 161 ? -16.38618 27.21411  26.41050  1.000 37.61235  ? 160 LEU A CD1  1 
ATOM   1347 C CD2  . LEU A 1 161 ? -18.68847 28.00054  25.86491  1.000 39.14728  ? 160 LEU A CD2  1 
ATOM   1348 N N    . GLY A 1 162 ? -15.99292 32.08865  23.31955  1.000 39.78964  ? 161 GLY A N    1 
ATOM   1349 C CA   . GLY A 1 162 ? -15.46921 33.46676  23.31019  1.000 44.99617  ? 161 GLY A CA   1 
ATOM   1350 C C    . GLY A 1 162 ? -14.42099 33.65117  24.38190  1.000 50.81582  ? 161 GLY A C    1 
ATOM   1351 O O    . GLY A 1 162 ? -14.35108 34.74528  24.94070  1.000 56.06900  ? 161 GLY A O    1 
ATOM   1352 N N    . LEU A 1 163 ? -13.63871 32.61337  24.64690  1.000 46.14929  ? 162 LEU A N    1 
ATOM   1353 C CA   . LEU A 1 163 ? -12.63046 32.64777  25.72465  1.000 54.20276  ? 162 LEU A CA   1 
ATOM   1354 C C    . LEU A 1 163 ? -11.22260 32.63296  25.12732  1.000 52.93018  ? 162 LEU A C    1 
ATOM   1355 O O    . LEU A 1 163 ? -10.26738 32.43229  25.88813  1.000 74.47838  ? 162 LEU A O    1 
ATOM   1356 C CB   . LEU A 1 163 ? -12.88100 31.42387  26.60593  1.000 54.47562  ? 162 LEU A CB   1 
ATOM   1357 C CG   . LEU A 1 163 ? -14.11580 31.50377  27.50121  1.000 59.34607  ? 162 LEU A CG   1 
ATOM   1358 C CD1  . LEU A 1 163 ? -14.33936 30.19185  28.22949  1.000 54.79963  ? 162 LEU A CD1  1 
ATOM   1359 C CD2  . LEU A 1 163 ? -13.98180 32.64697  28.49297  1.000 56.80768  ? 162 LEU A CD2  1 
ATOM   1360 N N    . GLU A 1 164 ? -11.10296 32.84575  23.82125  1.000 51.86567  ? 163 GLU A N    1 
ATOM   1361 C CA   . GLU A 1 164 ? -9.77312  32.85691  23.16394  1.000 68.87856  ? 163 GLU A CA   1 
ATOM   1362 C C    . GLU A 1 164 ? -9.61058  34.13080  22.33167  1.000 68.80244  ? 163 GLU A C    1 
ATOM   1363 O O    . GLU A 1 164 ? -9.92767  35.20883  22.86456  1.000 76.83230  ? 163 GLU A O    1 
ATOM   1364 C CB   . GLU A 1 164 ? -9.63408  31.63379  22.26812  1.000 61.21394  ? 163 GLU A CB   1 
ATOM   1365 C CG   . GLU A 1 164 ? -8.24418  31.46297  21.69081  1.000 67.34185  ? 163 GLU A CG   1 
ATOM   1366 C CD   . GLU A 1 164 ? -7.71487  30.04410  21.76794  1.000 69.21227  ? 163 GLU A CD   1 
ATOM   1367 O OE1  . GLU A 1 164 ? -8.15689  29.20487  20.96319  1.000 75.57453  ? 163 GLU A OE1  1 
ATOM   1368 O OE2  . GLU A 1 164 ? -6.86261  29.77942  22.63678  1.000 65.76573  ? 163 GLU A OE2  1 
ATOM   1369 N N    . MET B 1 1   ? 13.73240  27.24599  -11.75193 1.000 63.12785  ? 0   MET B N    1 
ATOM   1370 C CA   . MET B 1 1   ? 13.94068  27.48595  -10.29896 1.000 56.81728  ? 0   MET B CA   1 
ATOM   1371 C C    . MET B 1 1   ? 13.42981  26.27994  -9.50989  1.000 66.75008  ? 0   MET B C    1 
ATOM   1372 O O    . MET B 1 1   ? 12.44072  25.65797  -9.93372  1.000 58.95362  ? 0   MET B O    1 
ATOM   1373 C CB   . MET B 1 1   ? 13.20979  28.74696  -9.83480  1.000 55.51354  ? 0   MET B CB   1 
ATOM   1374 C CG   . MET B 1 1   ? 13.35808  29.03992  -8.35982  1.000 66.52644  ? 0   MET B CG   1 
ATOM   1375 S SD   . MET B 1 1   ? 15.05817  29.46788  -7.93213  1.000 120.85434 ? 0   MET B SD   1 
ATOM   1376 C CE   . MET B 1 1   ? 14.89851  29.71685  -6.16710  1.000 88.67115  ? 0   MET B CE   1 
ATOM   1377 N N    . ASP B 1 2   ? 14.07802  25.98591  -8.38602  1.000 63.91159  ? 1   ASP B N    1 
ATOM   1378 C CA   . ASP B 1 2   ? 13.70516  24.79090  -7.58998  1.000 65.06993  ? 1   ASP B CA   1 
ATOM   1379 C C    . ASP B 1 2   ? 12.52234  25.12290  -6.67975  1.000 51.29559  ? 1   ASP B C    1 
ATOM   1380 O O    . ASP B 1 2   ? 11.68036  24.24791  -6.48560  1.000 55.22503  ? 1   ASP B O    1 
ATOM   1381 C CB   . ASP B 1 2   ? 14.92929  24.27886  -6.84023  1.000 54.32949  ? 1   ASP B CB   1 
ATOM   1382 C CG   . ASP B 1 2   ? 16.00111  23.71286  -7.75544  1.000 69.77375  ? 1   ASP B CG   1 
ATOM   1383 O OD1  . ASP B 1 2   ? 15.70988  23.52589  -8.95139  1.000 59.41540  ? 1   ASP B OD1  1 
ATOM   1384 O OD2  . ASP B 1 2   ? 17.11420  23.46083  -7.26066  1.000 61.15761  ? 1   ASP B OD2  1 
ATOM   1385 N N    . GLU B 1 3   ? 12.44945  26.34889  -6.17570  1.000 46.18371  ? 2   GLU B N    1 
ATOM   1386 C CA   . GLU B 1 3   ? 11.39165  26.68188  -5.19249  1.000 61.90270  ? 2   GLU B CA   1 
ATOM   1387 C C    . GLU B 1 3   ? 10.03352  26.77492  -5.88723  1.000 52.39868  ? 2   GLU B C    1 
ATOM   1388 O O    . GLU B 1 3   ? 9.02963   26.45992  -5.24805  1.000 52.18782  ? 2   GLU B O    1 
ATOM   1389 C CB   . GLU B 1 3   ? 11.75181  27.95286  -4.42653  1.000 61.79092  ? 2   GLU B CB   1 
ATOM   1390 C CG   . GLU B 1 3   ? 12.56205  27.68182  -3.17470  1.000 65.62798  ? 2   GLU B CG   1 
ATOM   1391 C CD   . GLU B 1 3   ? 11.75730  27.67180  -1.88654  1.000 73.23339  ? 2   GLU B CD   1 
ATOM   1392 O OE1  . GLU B 1 3   ? 10.51528  27.68682  -1.96530  1.000 77.49362  ? 2   GLU B OE1  1 
ATOM   1393 O OE2  . GLU B 1 3   ? 12.37650  27.65077  -0.80966  1.000 68.63159  ? 2   GLU B OE2  1 
ATOM   1394 N N    . GLU B 1 4   ? 10.01528  27.14995  -7.15622  1.000 48.85099  ? 3   GLU B N    1 
ATOM   1395 C CA   . GLU B 1 4   ? 8.73214   27.15199  -7.90297  1.000 56.31197  ? 3   GLU B CA   1 
ATOM   1396 C C    . GLU B 1 4   ? 8.25808   25.70600  -8.08292  1.000 44.91348  ? 3   GLU B C    1 
ATOM   1397 O O    . GLU B 1 4   ? 7.06210   25.46501  -7.95069  1.000 48.09820  ? 3   GLU B O    1 
ATOM   1398 C CB   . GLU B 1 4   ? 8.88389   27.86101  -9.24799  1.000 46.05248  ? 3   GLU B CB   1 
ATOM   1399 C CG   . GLU B 1 4   ? 7.56278   28.29905  -9.84772  1.000 64.54384  ? 3   GLU B CG   1 
ATOM   1400 C CD   . GLU B 1 4   ? 6.88060   27.26908  -10.72862 1.000 70.34771  ? 3   GLU B CD   1 
ATOM   1401 O OE1  . GLU B 1 4   ? 7.53751   26.27708  -11.09577 1.000 76.54293  ? 3   GLU B OE1  1 
ATOM   1402 O OE2  . GLU B 1 4   ? 5.69654   27.46411  -11.05239 1.000 68.21215  ? 3   GLU B OE2  1 
ATOM   1403 N N    . ARG B 1 5   ? 9.18501   24.79999  -8.37411  1.000 40.22449  ? 4   ARG B N    1 
ATOM   1404 C CA   . ARG B 1 5   ? 8.82895   23.37800  -8.56608  1.000 41.59911  ? 4   ARG B CA   1 
ATOM   1405 C C    . ARG B 1 5   ? 8.33619   22.79798  -7.23600  1.000 36.87187  ? 4   ARG B C    1 
ATOM   1406 O O    . ARG B 1 5   ? 7.40717   21.99699  -7.26684  1.000 43.01690  ? 4   ARG B O    1 
ATOM   1407 C CB   . ARG B 1 5   ? 10.02883  22.60599  -9.11533  1.000 42.63540  ? 4   ARG B CB   1 
ATOM   1408 C CG   . ARG B 1 5   ? 9.70773   21.17101  -9.51030  1.000 51.97051  ? 4   ARG B CG   1 
ATOM   1409 C CD   . ARG B 1 5   ? 8.45457   21.06705  -10.35506 1.000 40.15583  ? 4   ARG B CD   1 
ATOM   1410 N NE   . ARG B 1 5   ? 8.04951   19.68406  -10.53101 1.000 37.87492  ? 4   ARG B NE   1 
ATOM   1411 C CZ   . ARG B 1 5   ? 6.83344   19.29208  -10.88379 1.000 39.69021  ? 4   ARG B CZ   1 
ATOM   1412 N NH1  . ARG B 1 5   ? 5.89041   20.18411  -11.11359 1.000 35.31562  ? 4   ARG B NH1  1 
ATOM   1413 N NH2  . ARG B 1 5   ? 6.56639   18.00609  -11.01477 1.000 32.29502  ? 4   ARG B NH2  1 
ATOM   1414 N N    . LEU B 1 6   ? 8.94141   23.21294  -6.12710  1.000 40.90407  ? 5   LEU B N    1 
ATOM   1415 C CA   . LEU B 1 6   ? 8.53066   22.71392  -4.79004  1.000 42.55446  ? 5   LEU B CA   1 
ATOM   1416 C C    . LEU B 1 6   ? 7.05671   23.05894  -4.57575  1.000 37.94670  ? 5   LEU B C    1 
ATOM   1417 O O    . LEU B 1 6   ? 6.28876   22.17094  -4.20962  1.000 30.17866  ? 5   LEU B O    1 
ATOM   1418 C CB   . LEU B 1 6   ? 9.41787   23.36388  -3.73219  1.000 46.33045  ? 5   LEU B CB   1 
ATOM   1419 C CG   . LEU B 1 6   ? 9.90207   22.44485  -2.61130  1.000 58.65620  ? 5   LEU B CG   1 
ATOM   1420 C CD1  . LEU B 1 6   ? 10.39794  21.12285  -3.17343  1.000 56.33578  ? 5   LEU B CD1  1 
ATOM   1421 C CD2  . LEU B 1 6   ? 11.00224  23.12281  -1.81150  1.000 61.04651  ? 5   LEU B CD2  1 
ATOM   1422 N N    . LYS B 1 7   ? 6.70067   24.30895  -4.84965  1.000 35.26412  ? 6   LYS B N    1 
ATOM   1423 C CA   . LYS B 1 7   ? 5.30171   24.75297  -4.68437  1.000 37.71492  ? 6   LYS B CA   1 
ATOM   1424 C C    . LYS B 1 7   ? 4.41152   23.93601  -5.61722  1.000 39.03597  ? 6   LYS B C    1 
ATOM   1425 O O    . LYS B 1 7   ? 3.39060   23.43201  -5.14704  1.000 49.92986  ? 6   LYS B O    1 
ATOM   1426 C CB   . LYS B 1 7   ? 5.17868   26.24698  -4.97431  1.000 42.32738  ? 6   LYS B CB   1 
ATOM   1427 C CG   . LYS B 1 7   ? 3.78772   26.83500  -4.80004  1.000 53.26313  ? 6   LYS B CG   1 
ATOM   1428 C CD   . LYS B 1 7   ? 3.69666   28.26701  -5.27399  1.000 52.90457  ? 6   LYS B CD   1 
ATOM   1429 C CE   . LYS B 1 7   ? 2.59680   29.05601  -4.60076  1.000 66.33529  ? 6   LYS B CE   1 
ATOM   1430 N NZ   . LYS B 1 7   ? 2.78379   30.51501  -4.77776  1.000 70.61188  ? 6   LYS B NZ   1 
ATOM   1431 N N    . GLU B 1 8   ? 4.82328   23.78603  -6.86930  1.000 29.06574  ? 7   GLU B N    1 
ATOM   1432 C CA   . GLU B 1 8   ? 4.02108   23.02806  -7.85217  1.000 34.05122  ? 7   GLU B CA   1 
ATOM   1433 C C    . GLU B 1 8   ? 3.79215   21.60206  -7.35115  1.000 26.90310  ? 7   GLU B C    1 
ATOM   1434 O O    . GLU B 1 8   ? 2.65213   21.15308  -7.42095  1.000 33.61356  ? 7   GLU B O    1 
ATOM   1435 C CB   . GLU B 1 8   ? 4.77282   22.95708  -9.18531  1.000 35.14239  ? 7   GLU B CB   1 
ATOM   1436 C CG   . GLU B 1 8   ? 4.77569   24.24410  -9.98528  1.000 61.32299  ? 7   GLU B CG   1 
ATOM   1437 C CD   . GLU B 1 8   ? 5.30342   24.06912  -11.39939 1.000 65.06570  ? 7   GLU B CD   1 
ATOM   1438 O OE1  . GLU B 1 8   ? 5.83234   22.98712  -11.70351 1.000 54.38812  ? 7   GLU B OE1  1 
ATOM   1439 O OE2  . GLU B 1 8   ? 5.17928   25.01214  -12.19334 1.000 66.09105  ? 7   GLU B OE2  1 
ATOM   1440 N N    . ILE B 1 9   ? 4.84123   20.93603  -6.87237  1.000 23.37636  ? 8   ILE B N    1 
ATOM   1441 C CA   . ILE B 1 9   ? 4.73829   19.51502  -6.44038  1.000 28.60256  ? 8   ILE B CA   1 
ATOM   1442 C C    . ILE B 1 9   ? 3.80552   19.41401  -5.23021  1.000 25.81102  ? 8   ILE B C    1 
ATOM   1443 O O    . ILE B 1 9   ? 2.92951   18.55102  -5.23406  1.000 34.72690  ? 8   ILE B O    1 
ATOM   1444 C CB   . ILE B 1 9   ? 6.13934   18.94399  -6.14766  1.000 29.36864  ? 8   ILE B CB   1 
ATOM   1445 C CG1  . ILE B 1 9   ? 7.04210   19.00200  -7.38283  1.000 41.89824  ? 8   ILE B CG1  1 
ATOM   1446 C CG2  . ILE B 1 9   ? 6.04642   17.53798  -5.57968  1.000 27.71174  ? 8   ILE B CG2  1 
ATOM   1447 C CD1  . ILE B 1 9   ? 8.47915   18.63897  -7.10712  1.000 31.77368  ? 8   ILE B CD1  1 
ATOM   1448 N N    . LEU B 1 10  ? 3.98672   20.29598  -4.26222  1.000 29.19490  ? 9   LEU B N    1 
ATOM   1449 C CA   . LEU B 1 10  ? 3.16195   20.23097  -3.03306  1.000 32.75042  ? 9   LEU B CA   1 
ATOM   1450 C C    . LEU B 1 10  ? 1.69189   20.47400  -3.39778  1.000 32.10596  ? 9   LEU B C    1 
ATOM   1451 O O    . LEU B 1 10  ? 0.84697   19.74600  -2.89763  1.000 31.36373  ? 9   LEU B O    1 
ATOM   1452 C CB   . LEU B 1 10  ? 3.70917   21.22694  -2.00815  1.000 30.40555  ? 9   LEU B CB   1 
ATOM   1453 C CG   . LEU B 1 10  ? 5.02329   20.82290  -1.34841  1.000 32.53221  ? 9   LEU B CG   1 
ATOM   1454 C CD1  . LEU B 1 10  ? 5.65644   22.00087  -0.62750  1.000 30.52999  ? 9   LEU B CD1  1 
ATOM   1455 C CD2  . LEU B 1 10  ? 4.80945   19.65988  -0.39339  1.000 27.40829  ? 9   LEU B CD2  1 
ATOM   1456 N N    . GLU B 1 11  ? 1.42073   21.39303  -4.32270  1.000 30.26222  ? 10  GLU B N    1 
ATOM   1457 C CA   . GLU B 1 11  ? 0.01966   21.73106  -4.69443  1.000 32.64386  ? 10  GLU B CA   1 
ATOM   1458 C C    . GLU B 1 11  ? -0.61451  20.58509  -5.48533  1.000 31.74314  ? 10  GLU B C    1 
ATOM   1459 O O    . GLU B 1 11  ? -1.81048  20.35310  -5.30311  1.000 36.87364  ? 10  GLU B O    1 
ATOM   1460 C CB   . GLU B 1 11  ? -0.01846  23.05408  -5.45439  1.000 40.61300  ? 10  GLU B CB   1 
ATOM   1461 C CG   . GLU B 1 11  ? 0.31773   24.24205  -4.57443  1.000 47.12924  ? 10  GLU B CG   1 
ATOM   1462 C CD   . GLU B 1 11  ? 0.39061   25.58006  -5.28941  1.000 60.51440  ? 10  GLU B CD   1 
ATOM   1463 O OE1  . GLU B 1 11  ? 0.78238   25.59708  -6.46949  1.000 58.78586  ? 10  GLU B OE1  1 
ATOM   1464 O OE2  . GLU B 1 11  ? 0.05975   26.59806  -4.65833  1.000 65.10580  ? 10  GLU B OE2  1 
ATOM   1465 N N    . GLU B 1 12  ? 0.16732   19.89209  -6.30650  1.000 32.12977  ? 11  GLU B N    1 
ATOM   1466 C CA   . GLU B 1 12  ? -0.34384  18.72112  -7.05443  1.000 31.29645  ? 11  GLU B CA   1 
ATOM   1467 C C    . GLU B 1 12  ? -0.61267  17.57710  -6.07540  1.000 28.95383  ? 11  GLU B C    1 
ATOM   1468 O O    . GLU B 1 12  ? -1.62971  16.90912  -6.22722  1.000 33.39097  ? 11  GLU B O    1 
ATOM   1469 C CB   . GLU B 1 12  ? 0.65795   18.30312  -8.12463  1.000 29.20827  ? 11  GLU B CB   1 
ATOM   1470 C CG   . GLU B 1 12  ? 0.17276   17.16715  -8.99956  1.000 29.10984  ? 11  GLU B CG   1 
ATOM   1471 C CD   . GLU B 1 12  ? -1.14237  17.44319  -9.70630  1.000 50.02835  ? 11  GLU B CD   1 
ATOM   1472 O OE1  . GLU B 1 12  ? -1.42341  18.62020  -9.99522  1.000 47.21421  ? 11  GLU B OE1  1 
ATOM   1473 O OE2  . GLU B 1 12  ? -1.88343  16.48321  -9.95918  1.000 54.38353  ? 11  GLU B OE2  1 
ATOM   1474 N N    . LEU B 1 13  ? 0.27351   17.38806  -5.10058  1.000 32.27490  ? 12  LEU B N    1 
ATOM   1475 C CA   . LEU B 1 13  ? 0.08269   16.33504  -4.06956  1.000 34.42021  ? 12  LEU B CA   1 
ATOM   1476 C C    . LEU B 1 13  ? -1.22516  16.59505  -3.31431  1.000 24.16514  ? 12  LEU B C    1 
ATOM   1477 O O    . LEU B 1 13  ? -1.93612  15.63705  -3.04919  1.000 32.08022  ? 12  LEU B O    1 
ATOM   1478 C CB   . LEU B 1 13  ? 1.30287   16.33000  -3.14680  1.000 28.35188  ? 12  LEU B CB   1 
ATOM   1479 C CG   . LEU B 1 13  ? 2.53075   15.61799  -3.70505  1.000 33.75440  ? 12  LEU B CG   1 
ATOM   1480 C CD1  . LEU B 1 13  ? 3.75292   15.90295  -2.85427  1.000 33.45988  ? 12  LEU B CD1  1 
ATOM   1481 C CD2  . LEU B 1 13  ? 2.28771   14.12300  -3.80603  1.000 29.30893  ? 12  LEU B CD2  1 
ATOM   1482 N N    . GLU B 1 14  ? -1.56409  17.85805  -3.08521  1.000 29.04790  ? 13  GLU B N    1 
ATOM   1483 C CA   . GLU B 1 14  ? -2.82396  18.21405  -2.38596  1.000 35.71263  ? 13  GLU B CA   1 
ATOM   1484 C C    . GLU B 1 14  ? -4.02513  17.85209  -3.26274  1.000 33.06697  ? 13  GLU B C    1 
ATOM   1485 O O    . GLU B 1 14  ? -4.97904  17.26710  -2.74657  1.000 36.18899  ? 13  GLU B O    1 
ATOM   1486 C CB   . GLU B 1 14  ? -2.79686  19.69604  -2.00494  1.000 33.80090  ? 13  GLU B CB   1 
ATOM   1487 C CG   . GLU B 1 14  ? -1.90163  20.01000  -0.83010  1.000 31.31425  ? 13  GLU B CG   1 
ATOM   1488 C CD   . GLU B 1 14  ? -1.89353  21.48199  -0.47007  1.000 45.87963  ? 13  GLU B CD   1 
ATOM   1489 O OE1  . GLU B 1 14  ? -2.10769  22.30002  -1.37201  1.000 45.88863  ? 13  GLU B OE1  1 
ATOM   1490 O OE2  . GLU B 1 14  ? -1.67530  21.80196  0.70490   1.000 41.22338  ? 13  GLU B OE2  1 
ATOM   1491 N N    . ARG B 1 15  ? -3.95537  18.16812  -4.55375  1.000 38.97127  ? 14  ARG B N    1 
ATOM   1492 C CA   . ARG B 1 15  ? -5.07455  17.88216  -5.48454  1.000 36.67585  ? 14  ARG B CA   1 
ATOM   1493 C C    . ARG B 1 15  ? -5.26760  16.36916  -5.58554  1.000 28.80967  ? 14  ARG B C    1 
ATOM   1494 O O    . ARG B 1 15  ? -6.40661  15.92318  -5.62033  1.000 34.32835  ? 14  ARG B O    1 
ATOM   1495 C CB   . ARG B 1 15  ? -4.79581  18.51219  -6.85358  1.000 39.60224  ? 14  ARG B CB   1 
ATOM   1496 C CG   . ARG B 1 15  ? -4.54577  20.01118  -6.80859  1.000 54.61326  ? 14  ARG B CG   1 
ATOM   1497 C CD   . ARG B 1 15  ? -4.70602  20.65821  -8.16855  1.000 57.03509  ? 14  ARG B CD   1 
ATOM   1498 N NE   . ARG B 1 15  ? -4.20700  22.02321  -8.18861  1.000 69.85289  ? 14  ARG B NE   1 
ATOM   1499 C CZ   . ARG B 1 15  ? -2.95305  22.36119  -8.46985  1.000 64.72410  ? 14  ARG B CZ   1 
ATOM   1500 N NH1  . ARG B 1 15  ? -2.06612  21.42318  -8.75504  1.000 50.24089  ? 14  ARG B NH1  1 
ATOM   1501 N NH2  . ARG B 1 15  ? -2.59103  23.63119  -8.46189  1.000 57.88274  ? 14  ARG B NH2  1 
ATOM   1502 N N    . ILE B 1 16  ? -4.16861  15.62815  -5.60976  1.000 27.20302  ? 15  ILE B N    1 
ATOM   1503 C CA   . ILE B 1 16  ? -4.24666  14.14915  -5.70078  1.000 33.33500  ? 15  ILE B CA   1 
ATOM   1504 C C    . ILE B 1 16  ? -4.91942  13.61713  -4.43267  1.000 37.05558  ? 15  ILE B C    1 
ATOM   1505 O O    . ILE B 1 16  ? -5.87646  12.85015  -4.56650  1.000 34.31449  ? 15  ILE B O    1 
ATOM   1506 C CB   . ILE B 1 16  ? -2.85071  13.54113  -5.93206  1.000 31.51593  ? 15  ILE B CB   1 
ATOM   1507 C CG1  . ILE B 1 16  ? -2.34698  13.81716  -7.35015  1.000 40.73759  ? 15  ILE B CG1  1 
ATOM   1508 C CG2  . ILE B 1 16  ? -2.84667  12.05613  -5.61210  1.000 31.78095  ? 15  ILE B CG2  1 
ATOM   1509 C CD1  . ILE B 1 16  ? -0.85199  13.97613  -7.45244  1.000 43.28381  ? 15  ILE B CD1  1 
ATOM   1510 N N    . ILE B 1 17  ? -4.45019  14.04410  -3.25675  1.000 38.51478  ? 16  ILE B N    1 
ATOM   1511 C CA   . ILE B 1 17  ? -5.00296  13.49408  -1.98465  1.000 35.72428  ? 16  ILE B CA   1 
ATOM   1512 C C    . ILE B 1 17  ? -6.49394  13.82210  -1.91036  1.000 37.37122  ? 16  ILE B C    1 
ATOM   1513 O O    . ILE B 1 17  ? -7.24786  12.98210  -1.42923  1.000 39.64875  ? 16  ILE B O    1 
ATOM   1514 C CB   . ILE B 1 17  ? -4.22571  13.99904  -0.75579  1.000 35.85697  ? 16  ILE B CB   1 
ATOM   1515 C CG1  . ILE B 1 17  ? -4.38750  13.06101  0.44422   1.000 46.65059  ? 16  ILE B CG1  1 
ATOM   1516 C CG2  . ILE B 1 17  ? -4.62262  15.42604  -0.41368  1.000 37.43723  ? 16  ILE B CG2  1 
ATOM   1517 C CD1  . ILE B 1 17  ? -4.03158  11.62602  0.14512   1.000 41.00458  ? 16  ILE B CD1  1 
ATOM   1518 N N    . GLU B 1 18  ? -6.88201  14.99112  -2.40826  1.000 34.04391  ? 17  GLU B N    1 
ATOM   1519 C CA   . GLU B 1 18  ? -8.30299  15.41014  -2.35198  1.000 39.72699  ? 17  GLU B CA   1 
ATOM   1520 C C    . GLU B 1 18  ? -9.12518  14.49618  -3.26584  1.000 35.11846  ? 17  GLU B C    1 
ATOM   1521 O O    . GLU B 1 18  ? -10.21611 14.10018  -2.86364  1.000 39.88239  ? 17  GLU B O    1 
ATOM   1522 C CB   . GLU B 1 18  ? -8.44004  16.89615  -2.69092  1.000 29.82111  ? 17  GLU B CB   1 
ATOM   1523 C CG   . GLU B 1 18  ? -7.82682  17.81312  -1.65201  1.000 40.61283  ? 17  GLU B CG   1 
ATOM   1524 C CD   . GLU B 1 18  ? -7.46589  19.20012  -2.15405  1.000 74.49907  ? 17  GLU B CD   1 
ATOM   1525 O OE1  . GLU B 1 18  ? -7.90910  19.56216  -3.26196  1.000 59.81835  ? 17  GLU B OE1  1 
ATOM   1526 O OE2  . GLU B 1 18  ? -6.74575  19.91510  -1.43417  1.000 74.93096  ? 17  GLU B OE2  1 
ATOM   1527 N N    . GLU B 1 19  ? -8.59441  14.17419  -4.43595  1.000 30.53483  ? 18  GLU B N    1 
ATOM   1528 C CA   . GLU B 1 19  ? -9.30061  13.26323  -5.36384  1.000 38.73376  ? 18  GLU B CA   1 
ATOM   1529 C C    . GLU B 1 19  ? -9.46151  11.88121  -4.72684  1.000 30.09051  ? 18  GLU B C    1 
ATOM   1530 O O    . GLU B 1 19  ? -10.53255 11.30124  -4.87564  1.000 41.78061  ? 18  GLU B O    1 
ATOM   1531 C CB   . GLU B 1 19  ? -8.56386  13.17424  -6.69798  1.000 39.56005  ? 18  GLU B CB   1 
ATOM   1532 C CG   . GLU B 1 19  ? -8.97404  11.98027  -7.53393  1.000 51.44221  ? 18  GLU B CG   1 
ATOM   1533 C CD   . GLU B 1 19  ? -10.29718 12.13631  -8.26467  1.000 70.58492  ? 18  GLU B CD   1 
ATOM   1534 O OE1  . GLU B 1 19  ? -10.78718 13.27532  -8.35655  1.000 69.06002  ? 18  GLU B OE1  1 
ATOM   1535 O OE2  . GLU B 1 19  ? -10.83229 11.11933  -8.73759  1.000 87.32736  ? 18  GLU B OE2  1 
ATOM   1536 N N    . VAL B 1 20  ? -8.42639  11.39618  -4.04604  1.000 33.18482  ? 19  VAL B N    1 
ATOM   1537 C CA   . VAL B 1 20  ? -8.49228  10.06917  -3.36606  1.000 37.01285  ? 19  VAL B CA   1 
ATOM   1538 C C    . VAL B 1 20  ? -9.57207  10.09916  -2.27585  1.000 31.30497  ? 19  VAL B C    1 
ATOM   1539 O O    . VAL B 1 20  ? -10.30706 9.12617   -2.16174  1.000 33.76573  ? 19  VAL B O    1 
ATOM   1540 C CB   . VAL B 1 20  ? -7.11718  9.66013   -2.80333  1.000 41.02212  ? 19  VAL B CB   1 
ATOM   1541 C CG1  . VAL B 1 20  ? -7.20901  8.48911   -1.83634  1.000 30.28978  ? 19  VAL B CG1  1 
ATOM   1542 C CG2  . VAL B 1 20  ? -6.12139  9.37914   -3.91353  1.000 34.36175  ? 19  VAL B CG2  1 
ATOM   1543 N N    . LYS B 1 21  ? -9.64290  11.18815  -1.51582  1.000 33.05211  ? 20  LYS B N    1 
ATOM   1544 C CA   . LYS B 1 21  ? -10.67070 11.33514  -0.45662  1.000 43.49328  ? 20  LYS B CA   1 
ATOM   1545 C C    . LYS B 1 21  ? -12.05382 11.23718  -1.09335  1.000 44.61259  ? 20  LYS B C    1 
ATOM   1546 O O    . LYS B 1 21  ? -12.89373 10.50118  -0.57121  1.000 36.38992  ? 20  LYS B O    1 
ATOM   1547 C CB   . LYS B 1 21  ? -10.48254 12.66512  0.28038   1.000 42.93191  ? 20  LYS B CB   1 
ATOM   1548 C CG   . LYS B 1 21  ? -11.25128 12.80810  1.58653   1.000 39.70578  ? 20  LYS B CG   1 
ATOM   1549 C CD   . LYS B 1 21  ? -11.05914 14.16008  2.23152   1.000 49.26886  ? 20  LYS B CD   1 
ATOM   1550 C CE   . LYS B 1 21  ? -11.36930 15.30811  1.29261   1.000 63.25006  ? 20  LYS B CE   1 
ATOM   1551 N NZ   . LYS B 1 21  ? -10.60321 16.52909  1.64149   1.000 77.14465  ? 20  LYS B NZ   1 
ATOM   1552 N N    . ARG B 1 22  ? -12.24902 11.95220  -2.19330  1.000 37.78102  ? 21  ARG B N    1 
ATOM   1553 C CA   . ARG B 1 22  ? -13.55316 11.93524  -2.89305  1.000 37.74616  ? 21  ARG B CA   1 
ATOM   1554 C C    . ARG B 1 22  ? -13.86026 10.50126  -3.32502  1.000 37.07945  ? 21  ARG B C    1 
ATOM   1555 O O    . ARG B 1 22  ? -14.99223 10.06927  -3.11782  1.000 44.52384  ? 21  ARG B O    1 
ATOM   1556 C CB   . ARG B 1 22  ? -13.49537 12.88127  -4.09404  1.000 39.64607  ? 21  ARG B CB   1 
ATOM   1557 N N    . LEU B 1 23  ? -12.87038 9.80725   -3.87423  1.000 42.49430  ? 22  LEU B N    1 
ATOM   1558 C CA   . LEU B 1 23  ? -13.09050 8.43727   -4.39822  1.000 42.15187  ? 22  LEU B CA   1 
ATOM   1559 C C    . LEU B 1 23  ? -13.49630 7.49225   -3.26616  1.000 34.00973  ? 22  LEU B C    1 
ATOM   1560 O O    . LEU B 1 23  ? -14.45635 6.74327   -3.43899  1.000 42.89657  ? 22  LEU B O    1 
ATOM   1561 C CB   . LEU B 1 23  ? -11.79764 7.98326   -5.07248  1.000 44.83855  ? 22  LEU B CB   1 
ATOM   1562 C CG   . LEU B 1 23  ? -11.50589 8.61829   -6.42952  1.000 56.65661  ? 22  LEU B CG   1 
ATOM   1563 C CD1  . LEU B 1 23  ? -10.13899 8.19828   -6.94279  1.000 47.28092  ? 22  LEU B CD1  1 
ATOM   1564 C CD2  . LEU B 1 23  ? -12.58409 8.25433   -7.43332  1.000 46.39111  ? 22  LEU B CD2  1 
ATOM   1565 N N    . LEU B 1 24  ? -12.78109 7.56021   -2.16330  1.000 29.34320  ? 23  LEU B N    1 
ATOM   1566 C CA   . LEU B 1 24  ? -13.05989 6.66819   -1.02726  1.000 35.85003  ? 23  LEU B CA   1 
ATOM   1567 C C    . LEU B 1 24  ? -14.45978 6.96920   -0.51999  1.000 43.35910  ? 23  LEU B C    1 
ATOM   1568 O O    . LEU B 1 24  ? -15.15673 6.03621   -0.15988  1.000 39.27193  ? 23  LEU B O    1 
ATOM   1569 C CB   . LEU B 1 24  ? -12.00667 6.93015   0.04954   1.000 52.49730  ? 23  LEU B CB   1 
ATOM   1570 C CG   . LEU B 1 24  ? -10.87168 5.91313   0.11530   1.000 60.86896  ? 23  LEU B CG   1 
ATOM   1571 C CD1  . LEU B 1 24  ? -9.85689  6.16414   -0.98689  1.000 73.48351  ? 23  LEU B CD1  1 
ATOM   1572 C CD2  . LEU B 1 24  ? -10.20042 5.96309   1.47217   1.000 67.62682  ? 23  LEU B CD2  1 
ATOM   1573 N N    . GLU B 1 25  ? -14.83976 8.24121   -0.52689  1.000 50.87580  ? 24  GLU B N    1 
ATOM   1574 C CA   . GLU B 1 25  ? -16.16066 8.65522   0.00437   1.000 47.64690  ? 24  GLU B CA   1 
ATOM   1575 C C    . GLU B 1 25  ? -17.25884 8.13326   -0.92343  1.000 42.06329  ? 24  GLU B C    1 
ATOM   1576 O O    . GLU B 1 25  ? -18.28475 7.68826   -0.41424  1.000 48.36879  ? 24  GLU B O    1 
ATOM   1577 C CB   . GLU B 1 25  ? -16.18059 10.16921  0.21741   1.000 36.93212  ? 24  GLU B CB   1 
ATOM   1578 C CG   . GLU B 1 25  ? -15.84831 10.55218  1.64536   1.000 57.23989  ? 24  GLU B CG   1 
ATOM   1579 C CD   . GLU B 1 25  ? -15.13125 11.87816  1.82025   1.000 60.66528  ? 24  GLU B CD   1 
ATOM   1580 O OE1  . GLU B 1 25  ? -15.06843 12.64618  0.84326   1.000 67.42280  ? 24  GLU B OE1  1 
ATOM   1581 O OE2  . GLU B 1 25  ? -14.64404 12.14413  2.93516   1.000 66.61187  ? 24  GLU B OE2  1 
ATOM   1582 N N    . LYS B 1 26  ? -17.02509 8.14228   -2.22647  1.000 39.64096  ? 25  LYS B N    1 
ATOM   1583 C CA   . LYS B 1 26  ? -18.02628 7.56232   -3.14929  1.000 50.83494  ? 25  LYS B CA   1 
ATOM   1584 C C    . LYS B 1 26  ? -18.14725 6.06032   -2.87230  1.000 49.79132  ? 25  LYS B C    1 
ATOM   1585 O O    . LYS B 1 26  ? -19.26227 5.54334   -2.92510  1.000 52.69154  ? 25  LYS B O    1 
ATOM   1586 C CB   . LYS B 1 26  ? -17.65055 7.83435   -4.60636  1.000 44.65927  ? 25  LYS B CB   1 
ATOM   1587 C CG   . LYS B 1 26  ? -18.77275 7.64339   -5.61415  1.000 39.99718  ? 25  LYS B CG   1 
ATOM   1588 C CD   . LYS B 1 26  ? -18.48399 8.30741   -6.93719  1.000 60.53334  ? 25  LYS B CD   1 
ATOM   1589 C CE   . LYS B 1 26  ? -17.07409 8.05240   -7.42446  1.000 77.21111  ? 25  LYS B CE   1 
ATOM   1590 N NZ   . LYS B 1 26  ? -17.02437 7.86343   -8.89248  1.000 77.47690  ? 25  LYS B NZ   1 
ATOM   1591 N N    . ASP B 1 27  ? -17.03921 5.39929   -2.58853  1.000 42.73353  ? 26  ASP B N    1 
ATOM   1592 C CA   . ASP B 1 27  ? -17.02618 3.93729   -2.35257  1.000 47.22543  ? 26  ASP B CA   1 
ATOM   1593 C C    . ASP B 1 27  ? -17.73894 3.59127   -1.03944  1.000 36.65154  ? 26  ASP B C    1 
ATOM   1594 O O    . ASP B 1 27  ? -18.43195 2.58528   -1.02133  1.000 47.51516  ? 26  ASP B O    1 
ATOM   1595 C CB   . ASP B 1 27  ? -15.58920 3.43226   -2.41385  1.000 45.47545  ? 26  ASP B CB   1 
ATOM   1596 C CG   . ASP B 1 27  ? -15.40332 1.99727   -2.87192  1.000 50.39990  ? 26  ASP B CG   1 
ATOM   1597 O OD1  . ASP B 1 27  ? -16.39939 1.32929   -3.18074  1.000 46.27059  ? 26  ASP B OD1  1 
ATOM   1598 O OD2  . ASP B 1 27  ? -14.24733 1.57025   -2.92115  1.000 53.61878  ? 26  ASP B OD2  1 
ATOM   1599 N N    . GLU B 1 28  ? -17.55773 4.39724   0.00055   1.000 38.01373  ? 27  GLU B N    1 
ATOM   1600 C CA   . GLU B 1 28  ? -18.29449 4.16922   1.26868   1.000 44.74433  ? 27  GLU B CA   1 
ATOM   1601 C C    . GLU B 1 28  ? -19.79353 4.33326   1.02597   1.000 43.65851  ? 27  GLU B C    1 
ATOM   1602 O O    . GLU B 1 28  ? -20.55644 3.55326   1.57310   1.000 52.56779  ? 27  GLU B O    1 
ATOM   1603 C CB   . GLU B 1 28  ? -17.88727 5.18719   2.32463   1.000 46.61390  ? 27  GLU B CB   1 
ATOM   1604 C CG   . GLU B 1 28  ? -16.44519 5.09816   2.75435   1.000 67.05291  ? 27  GLU B CG   1 
ATOM   1605 C CD   . GLU B 1 28  ? -15.97504 6.37314   3.42529   1.000 72.42222  ? 27  GLU B CD   1 
ATOM   1606 O OE1  . GLU B 1 28  ? -16.49883 6.69312   4.50340   1.000 63.67022  ? 27  GLU B OE1  1 
ATOM   1607 O OE2  . GLU B 1 28  ? -15.10014 7.04814   2.85714   1.000 80.41382  ? 27  GLU B OE2  1 
ATOM   1608 N N    . ARG B 1 29  ? -20.17667 5.31328   0.21607   1.000 43.60729  ? 28  ARG B N    1 
ATOM   1609 C CA   . ARG B 1 29  ? -21.59772 5.59931   -0.07065  1.000 55.73966  ? 28  ARG B CA   1 
ATOM   1610 C C    . ARG B 1 29  ? -22.24289 4.43034   -0.83456  1.000 51.86067  ? 28  ARG B C    1 
ATOM   1611 O O    . ARG B 1 29  ? -23.33782 4.02735   -0.45836  1.000 53.29297  ? 28  ARG B O    1 
ATOM   1612 C CB   . ARG B 1 29  ? -21.70284 6.91733   -0.83160  1.000 44.95929  ? 28  ARG B CB   1 
ATOM   1613 C CG   . ARG B 1 29  ? -21.77765 8.15131   0.05444   1.000 53.24559  ? 28  ARG B CG   1 
ATOM   1614 C CD   . ARG B 1 29  ? -22.41378 9.31334   -0.68441  1.000 48.73532  ? 28  ARG B CD   1 
ATOM   1615 N NE   . ARG B 1 29  ? -21.99304 9.37236   -2.07549  1.000 48.83339  ? 28  ARG B NE   1 
ATOM   1616 C CZ   . ARG B 1 29  ? -20.91011 10.00635  -2.49869  1.000 46.21924  ? 28  ARG B CZ   1 
ATOM   1617 N NH1  . ARG B 1 29  ? -20.14594 10.64032  -1.63082  1.000 32.34218  ? 28  ARG B NH1  1 
ATOM   1618 N NH2  . ARG B 1 29  ? -20.60136 10.00738  -3.78074  1.000 56.18318  ? 28  ARG B NH2  1 
ATOM   1619 N N    . LEU B 1 30  ? -21.59209 3.92835   -1.88169  1.000 44.85942  ? 29  LEU B N    1 
ATOM   1620 C CA   . LEU B 1 30  ? -22.16927 2.83238   -2.69461  1.000 54.35999  ? 29  LEU B CA   1 
ATOM   1621 C C    . LEU B 1 30  ? -22.28712 1.56736   -1.83861  1.000 49.33225  ? 29  LEU B C    1 
ATOM   1622 O O    . LEU B 1 30  ? -23.31915 0.90438   -1.91143  1.000 55.37929  ? 29  LEU B O    1 
ATOM   1623 C CB   . LEU B 1 30  ? -21.27550 2.59239   -3.91178  1.000 46.06110  ? 29  LEU B CB   1 
ATOM   1624 C CG   . LEU B 1 30  ? -19.83145 2.20136   -3.60907  1.000 52.79708  ? 29  LEU B CG   1 
ATOM   1625 C CD1  . LEU B 1 30  ? -19.66149 0.69236   -3.65213  1.000 67.18568  ? 29  LEU B CD1  1 
ATOM   1626 C CD2  . LEU B 1 30  ? -18.87563 2.87137   -4.58124  1.000 78.02092  ? 29  LEU B CD2  1 
ATOM   1627 N N    . LEU B 1 31  ? -21.26098 1.27133   -1.04882  1.000 42.88274  ? 30  LEU B N    1 
ATOM   1628 C CA   . LEU B 1 31  ? -21.26284 0.05931   -0.19484  1.000 50.75189  ? 30  LEU B CA   1 
ATOM   1629 C C    . LEU B 1 31  ? -22.33763 0.18830   0.89137   1.000 59.62423  ? 30  LEU B C    1 
ATOM   1630 O O    . LEU B 1 31  ? -23.00159 -0.81470  1.18347   1.000 56.03852  ? 30  LEU B O    1 
ATOM   1631 C CB   . LEU B 1 31  ? -19.86372 -0.10273  0.40689   1.000 47.58138  ? 30  LEU B CB   1 
ATOM   1632 C CG   . LEU B 1 31  ? -18.81591 -0.73473  -0.50533  1.000 47.70572  ? 30  LEU B CG   1 
ATOM   1633 C CD1  . LEU B 1 31  ? -17.41381 -0.41076  -0.02259  1.000 58.00146  ? 30  LEU B CD1  1 
ATOM   1634 C CD2  . LEU B 1 31  ? -19.01495 -2.23772  -0.58732  1.000 51.22960  ? 30  LEU B CD2  1 
ATOM   1635 N N    . ARG B 1 32  ? -22.50650 1.38429   1.44643   1.000 48.33136  ? 31  ARG B N    1 
ATOM   1636 C CA   . ARG B 1 32  ? -23.53630 1.61528   2.47963   1.000 44.55295  ? 31  ARG B CA   1 
ATOM   1637 C C    . ARG B 1 32  ? -24.90442 1.35032   1.85788   1.000 58.00961  ? 31  ARG B C    1 
ATOM   1638 O O    . ARG B 1 32  ? -25.69532 0.61932   2.46102   1.000 60.96030  ? 31  ARG B O    1 
ATOM   1639 C CB   . ARG B 1 32  ? -23.41717 3.03927   3.02064   1.000 56.11930  ? 31  ARG B CB   1 
ATOM   1640 N N    . GLU B 1 33  ? -25.14964 1.91235   0.67494   1.000 56.68749  ? 32  GLU B N    1 
ATOM   1641 C CA   . GLU B 1 33  ? -26.44177 1.72639   -0.01981  1.000 68.65787  ? 32  GLU B CA   1 
ATOM   1642 C C    . GLU B 1 33  ? -26.70384 0.23240   -0.22880  1.000 76.82027  ? 32  GLU B C    1 
ATOM   1643 O O    . GLU B 1 33  ? -27.80178 -0.22759  0.11340   1.000 69.35373  ? 32  GLU B O    1 
ATOM   1644 C CB   . GLU B 1 33  ? -26.41802 2.44742   -1.36380  1.000 57.30535  ? 32  GLU B CB   1 
ATOM   1645 C CG   . GLU B 1 33  ? -27.73616 2.35746   -2.10155  1.000 81.05880  ? 32  GLU B CG   1 
ATOM   1646 C CD   . GLU B 1 33  ? -27.75140 3.11049   -3.42353  1.000 95.05023  ? 32  GLU B CD   1 
ATOM   1647 O OE1  . GLU B 1 33  ? -26.70446 3.68148   -3.78572  1.000 97.90113  ? 32  GLU B OE1  1 
ATOM   1648 O OE2  . GLU B 1 33  ? -28.80953 3.12652   -4.07633  1.000 104.21223 ? 32  GLU B OE2  1 
ATOM   1649 N N    . PHE B 1 34  ? -25.71795 -0.48861  -0.76100  1.000 54.73081  ? 33  PHE B N    1 
ATOM   1650 C CA   . PHE B 1 34  ? -25.89503 -1.93360  -1.03400  1.000 64.65559  ? 33  PHE B CA   1 
ATOM   1651 C C    . PHE B 1 34  ? -26.28779 -2.65462  0.25506   1.000 56.12117  ? 33  PHE B C    1 
ATOM   1652 O O    . PHE B 1 34  ? -27.33380 -3.31160  0.26824   1.000 59.84457  ? 33  PHE B O    1 
ATOM   1653 C CB   . PHE B 1 34  ? -24.62116 -2.52461  -1.64526  1.000 52.40039  ? 33  PHE B CB   1 
ATOM   1654 N N    . TYR B 1 35  ? -25.49359 -2.49666  1.30891   1.000 55.41317  ? 34  TYR B N    1 
ATOM   1655 C CA   . TYR B 1 35  ? -25.73936 -3.25668  2.56494   1.000 66.32097  ? 34  TYR B CA   1 
ATOM   1656 C C    . TYR B 1 35  ? -27.01722 -2.76668  3.26220   1.000 77.10919  ? 34  TYR B C    1 
ATOM   1657 O O    . TYR B 1 35  ? -27.57508 -3.54568  4.05029   1.000 85.40184  ? 34  TYR B O    1 
ATOM   1658 C CB   . TYR B 1 35  ? -24.48019 -3.21972  3.43270   1.000 64.04864  ? 34  TYR B CB   1 
ATOM   1659 C CG   . TYR B 1 35  ? -23.45329 -4.23773  3.01148   1.000 67.31119  ? 34  TYR B CG   1 
ATOM   1660 C CD1  . TYR B 1 35  ? -23.52623 -5.54874  3.44947   1.000 69.79542  ? 34  TYR B CD1  1 
ATOM   1661 C CD2  . TYR B 1 35  ? -22.42845 -3.90173  2.14429   1.000 70.34424  ? 34  TYR B CD2  1 
ATOM   1662 C CE1  . TYR B 1 35  ? -22.59932 -6.49474  3.05527   1.000 70.67330  ? 34  TYR B CE1  1 
ATOM   1663 C CE2  . TYR B 1 35  ? -21.49155 -4.83573  1.73709   1.000 66.62360  ? 34  TYR B CE2  1 
ATOM   1664 C CZ   . TYR B 1 35  ? -21.57748 -6.13774  2.19208   1.000 65.09910  ? 34  TYR B CZ   1 
ATOM   1665 O OH   . TYR B 1 35  ? -20.65757 -7.06275  1.79188   1.000 67.39099  ? 34  TYR B OH   1 
ATOM   1666 N N    . ARG B 1 36  ? -27.46625 -1.53566  2.99231   1.000 80.14824  ? 35  ARG B N    1 
ATOM   1667 C CA   . ARG B 1 36  ? -28.75314 -1.06065  3.55557   1.000 82.22910  ? 35  ARG B CA   1 
ATOM   1668 C C    . ARG B 1 36  ? -29.87327 -1.87862  2.92176   1.000 82.87119  ? 35  ARG B C    1 
ATOM   1669 O O    . ARG B 1 36  ? -30.94316 -1.97862  3.53197   1.000 88.57160  ? 35  ARG B O    1 
ATOM   1670 C CB   . ARG B 1 36  ? -28.99417 0.41836   3.24765   1.000 78.33826  ? 35  ARG B CB   1 
ATOM   1671 C CG   . ARG B 1 36  ? -28.59694 1.36832   4.36859   1.000 85.77768  ? 35  ARG B CG   1 
ATOM   1672 C CD   . ARG B 1 36  ? -29.46091 2.61634   4.40978   1.000 85.26511  ? 35  ARG B CD   1 
ATOM   1673 N NE   . ARG B 1 36  ? -28.93706 3.67935   3.56471   1.000 92.89837  ? 35  ARG B NE   1 
ATOM   1674 C CZ   . ARG B 1 36  ? -28.02497 4.56333   3.94355   1.000 86.30186  ? 35  ARG B CZ   1 
ATOM   1675 N NH1  . ARG B 1 36  ? -27.52674 4.51829   5.16646   1.000 75.02297  ? 35  ARG B NH1  1 
ATOM   1676 N NH2  . ARG B 1 36  ? -27.61111 5.49434   3.10050   1.000 76.23750  ? 35  ARG B NH2  1 
ATOM   1677 N N    . ARG B 1 37  ? -29.61351 -2.44060  1.74070   1.000 68.24885  ? 36  ARG B N    1 
ATOM   1678 C CA   . ARG B 1 37  ? -30.65566 -3.21157  1.01988   1.000 79.55466  ? 36  ARG B CA   1 
ATOM   1679 C C    . ARG B 1 37  ? -30.63059 -4.66458  1.49584   1.000 83.77289  ? 36  ARG B C    1 
ATOM   1680 O O    . ARG B 1 37  ? -31.23339 -4.92659  2.54795   1.000 91.74678  ? 36  ARG B O    1 
ATOM   1681 C CB   . ARG B 1 37  ? -30.40594 -3.14554  -0.48716  1.000 66.84333  ? 36  ARG B CB   1 
ATOM   1682 C CG   . ARG B 1 37  ? -29.95902 -1.78453  -0.99922  1.000 82.53816  ? 36  ARG B CG   1 
ATOM   1683 C CD   . ARG B 1 37  ? -29.25928 -1.95151  -2.33336  1.000 93.50373  ? 36  ARG B CD   1 
ATOM   1684 N NE   . ARG B 1 37  ? -30.16148 -2.51548  -3.32520  1.000 89.92126  ? 36  ARG B NE   1 
ATOM   1685 C CZ   . ARG B 1 37  ? -30.85763 -1.79444  -4.19705  1.000 98.12932  ? 36  ARG B CZ   1 
ATOM   1686 N NH1  . ARG B 1 37  ? -30.74361 -0.47745  -4.20604  1.000 85.74813  ? 36  ARG B NH1  1 
ATOM   1687 N NH2  . ARG B 1 37  ? -31.65881 -2.39241  -5.05791  1.000 104.57002 ? 36  ARG B NH2  1 
ATOM   1688 N N    . ASP B 1 41  ? -29.85176 -9.20246  -4.20241  1.000 85.67212  ? 40  ASP B N    1 
ATOM   1689 C CA   . ASP B 1 41  ? -29.68804 -9.54043  -5.64045  1.000 92.86241  ? 40  ASP B CA   1 
ATOM   1690 C C    . ASP B 1 41  ? -28.20310 -9.71345  -5.95873  1.000 91.07177  ? 40  ASP B C    1 
ATOM   1691 O O    . ASP B 1 41  ? -27.40700 -8.86847  -5.52487  1.000 91.67878  ? 40  ASP B O    1 
ATOM   1692 C CB   . ASP B 1 41  ? -30.31619 -8.47840  -6.54030  1.000 88.17174  ? 40  ASP B CB   1 
ATOM   1693 C CG   . ASP B 1 41  ? -30.79646 -9.01136  -7.87622  1.000 102.68528 ? 40  ASP B CG   1 
ATOM   1694 O OD1  . ASP B 1 41  ? -31.35648 -10.12235 -7.89514  1.000 102.74322 ? 40  ASP B OD1  1 
ATOM   1695 O OD2  . ASP B 1 41  ? -30.61264 -8.30634  -8.88424  1.000 103.51677 ? 40  ASP B OD2  1 
ATOM   1696 N N    . LYS B 1 42  ? -27.85926 -10.76044 -6.70482  1.000 89.12391  ? 41  LYS B N    1 
ATOM   1697 C CA   . LYS B 1 42  ? -26.44133 -11.03845 -7.03610  1.000 80.41963  ? 41  LYS B CA   1 
ATOM   1698 C C    . LYS B 1 42  ? -25.91149 -9.95644  -7.97318  1.000 81.25606  ? 41  LYS B C    1 
ATOM   1699 O O    . LYS B 1 42  ? -24.79844 -9.49246  -7.75438  1.000 83.43874  ? 41  LYS B O    1 
ATOM   1700 C CB   . LYS B 1 42  ? -26.31348 -12.41344 -7.69016  1.000 83.09455  ? 41  LYS B CB   1 
ATOM   1701 C CG   . LYS B 1 42  ? -26.85034 -13.57645 -6.86908  1.000 94.61178  ? 41  LYS B CG   1 
ATOM   1702 C CD   . LYS B 1 42  ? -25.76323 -14.42348 -6.24831  1.000 92.97330  ? 41  LYS B CD   1 
ATOM   1703 C CE   . LYS B 1 42  ? -26.21320 -15.83848 -5.95125  1.000 90.05342  ? 41  LYS B CE   1 
ATOM   1704 N NZ   . LYS B 1 42  ? -26.04844 -16.72446 -7.12730  1.000 88.60096  ? 41  LYS B NZ   1 
ATOM   1705 N N    . GLU B 1 43  ? -26.69068 -9.59241  -8.98502  1.000 68.94975  ? 42  GLU B N    1 
ATOM   1706 C CA   . GLU B 1 43  ? -26.25884 -8.53939  -9.93608  1.000 85.56495  ? 42  GLU B CA   1 
ATOM   1707 C C    . GLU B 1 43  ? -25.92667 -7.25041  -9.17511  1.000 87.97494  ? 42  GLU B C    1 
ATOM   1708 O O    . GLU B 1 43  ? -24.96174 -6.59542  -9.57528  1.000 90.95769  ? 42  GLU B O    1 
ATOM   1709 C CB   . GLU B 1 43  ? -27.32104 -8.31135  -11.00687 1.000 73.52424  ? 42  GLU B CB   1 
ATOM   1710 C CG   . GLU B 1 43  ? -27.30027 -9.35733  -12.10690 1.000 89.45593  ? 42  GLU B CG   1 
ATOM   1711 C CD   . GLU B 1 43  ? -25.92337 -9.81434  -12.56217 1.000 103.83643 ? 42  GLU B CD   1 
ATOM   1712 O OE1  . GLU B 1 43  ? -25.20147 -9.00134  -13.17729 1.000 102.89657 ? 42  GLU B OE1  1 
ATOM   1713 O OE2  . GLU B 1 43  ? -25.58234 -10.98835 -12.31526 1.000 91.74773  ? 42  GLU B OE2  1 
ATOM   1714 N N    . GLU B 1 44  ? -26.70247 -6.89442  -8.14396  1.000 83.14469  ? 43  GLU B N    1 
ATOM   1715 C CA   . GLU B 1 44  ? -26.40129 -5.70545  -7.30399  1.000 74.06914  ? 43  GLU B CA   1 
ATOM   1716 C C    . GLU B 1 44  ? -24.99318 -5.84148  -6.73226  1.000 71.55403  ? 43  GLU B C    1 
ATOM   1717 O O    . GLU B 1 44  ? -24.23019 -4.88749  -6.86039  1.000 83.83258  ? 43  GLU B O    1 
ATOM   1718 C CB   . GLU B 1 44  ? -27.38307 -5.58746  -6.14380  1.000 74.50182  ? 43  GLU B CB   1 
ATOM   1719 C CG   . GLU B 1 44  ? -28.63012 -4.79043  -6.46754  1.000 95.95022  ? 43  GLU B CG   1 
ATOM   1720 C CD   . GLU B 1 44  ? -29.86197 -5.14943  -5.65031  1.000 107.42467 ? 43  GLU B CD   1 
ATOM   1721 O OE1  . GLU B 1 44  ? -29.70774 -5.50846  -4.46635  1.000 109.38824 ? 43  GLU B OE1  1 
ATOM   1722 O OE2  . GLU B 1 44  ? -30.97807 -5.06540  -6.20110  1.000 101.51643 ? 43  GLU B OE2  1 
ATOM   1723 N N    . PHE B 1 45  ? -24.67709 -6.98950  -6.14235  1.000 66.79303  ? 44  PHE B N    1 
ATOM   1724 C CA   . PHE B 1 45  ? -23.33098 -7.22854  -5.56661  1.000 71.93208  ? 44  PHE B CA   1 
ATOM   1725 C C    . PHE B 1 45  ? -22.26319 -7.14853  -6.66081  1.000 73.44725  ? 44  PHE B C    1 
ATOM   1726 O O    . PHE B 1 45  ? -21.23314 -6.52255  -6.44300  1.000 70.10725  ? 44  PHE B O    1 
ATOM   1727 C CB   . PHE B 1 45  ? -23.27487 -8.57656  -4.84765  1.000 68.02112  ? 44  PHE B CB   1 
ATOM   1728 C CG   . PHE B 1 45  ? -22.11769 -8.73160  -3.89388  1.000 68.53268  ? 44  PHE B CG   1 
ATOM   1729 C CD1  . PHE B 1 45  ? -21.91048 -7.81962  -2.87390  1.000 67.69185  ? 44  PHE B CD1  1 
ATOM   1730 C CD2  . PHE B 1 45  ? -21.23273 -9.78961  -4.01407  1.000 66.96174  ? 44  PHE B CD2  1 
ATOM   1731 C CE1  . PHE B 1 45  ? -20.84431 -7.95666  -2.00110  1.000 72.66606  ? 44  PHE B CE1  1 
ATOM   1732 C CE2  . PHE B 1 45  ? -20.17056 -9.93164  -3.13728  1.000 65.24014  ? 44  PHE B CE2  1 
ATOM   1733 C CZ   . PHE B 1 45  ? -19.97736 -9.01467  -2.13229  1.000 60.53088  ? 44  PHE B CZ   1 
ATOM   1734 N N    . ARG B 1 46  ? -22.47442 -7.81550  -7.78979  1.000 73.01478  ? 45  ARG B N    1 
ATOM   1735 C CA   . ARG B 1 46  ? -21.40161 -7.81650  -8.81099  1.000 66.27402  ? 45  ARG B CA   1 
ATOM   1736 C C    . ARG B 1 46  ? -21.12366 -6.36649  -9.18501  1.000 69.12824  ? 45  ARG B C    1 
ATOM   1737 O O    . ARG B 1 46  ? -19.96970 -6.05151  -9.43023  1.000 73.08286  ? 45  ARG B O    1 
ATOM   1738 C CB   . ARG B 1 46  ? -21.80786 -8.62846  -10.04193 1.000 70.66962  ? 45  ARG B CB   1 
ATOM   1739 N N    . ARG B 1 47  ? -22.15564 -5.52648  -9.16280  1.000 65.95135  ? 46  ARG B N    1 
ATOM   1740 C CA   . ARG B 1 47  ? -22.01370 -4.11147  -9.56379  1.000 82.72036  ? 46  ARG B CA   1 
ATOM   1741 C C    . ARG B 1 47  ? -21.17648 -3.36751  -8.51794  1.000 78.12666  ? 46  ARG B C    1 
ATOM   1742 O O    . ARG B 1 47  ? -20.35655 -2.52851  -8.91307  1.000 74.72435  ? 46  ARG B O    1 
ATOM   1743 C CB   . ARG B 1 47  ? -23.40173 -3.50244  -9.76651  1.000 73.57482  ? 46  ARG B CB   1 
ATOM   1744 C CG   . ARG B 1 47  ? -23.47193 -2.49042  -10.90248 1.000 75.09540  ? 46  ARG B CG   1 
ATOM   1745 C CD   . ARG B 1 47  ? -24.87903 -2.33238  -11.44520 1.000 82.55406  ? 46  ARG B CD   1 
ATOM   1746 N NE   . ARG B 1 47  ? -25.04529 -2.97335  -12.73919 1.000 102.79573 ? 46  ARG B NE   1 
ATOM   1747 C CZ   . ARG B 1 47  ? -26.11237 -3.67532  -13.10100 1.000 104.04228 ? 46  ARG B CZ   1 
ATOM   1748 N NH1  . ARG B 1 47  ? -27.12221 -3.82733  -12.25881 1.000 94.21201  ? 46  ARG B NH1  1 
ATOM   1749 N NH2  . ARG B 1 47  ? -26.16861 -4.22029  -14.30000 1.000 94.38493  ? 46  ARG B NH2  1 
ATOM   1750 N N    . VAL B 1 48  ? -21.38324 -3.67153  -7.23690  1.000 67.10088  ? 47  VAL B N    1 
ATOM   1751 C CA   . VAL B 1 48  ? -20.65103 -2.94357  -6.16303  1.000 72.77502  ? 47  VAL B CA   1 
ATOM   1752 C C    . VAL B 1 48  ? -19.18804 -3.38159  -6.19432  1.000 69.74983  ? 47  VAL B C    1 
ATOM   1753 O O    . VAL B 1 48  ? -18.31802 -2.50561  -6.15746  1.000 69.00550  ? 47  VAL B O    1 
ATOM   1754 C CB   . VAL B 1 48  ? -21.28977 -3.15959  -4.77791  1.000 73.55876  ? 47  VAL B CB   1 
ATOM   1755 C CG1  . VAL B 1 48  ? -22.78276 -2.86256  -4.79562  1.000 73.91965  ? 47  VAL B CG1  1 
ATOM   1756 C CG2  . VAL B 1 48  ? -21.01968 -4.54961  -4.22199  1.000 72.81570  ? 47  VAL B CG2  1 
ATOM   1757 N N    . ILE B 1 49  ? -18.94108 -4.68959  -6.27639  1.000 60.15313  ? 48  ILE B N    1 
ATOM   1758 C CA   . ILE B 1 49  ? -17.54110 -5.18862  -6.37267  1.000 65.85468  ? 48  ILE B CA   1 
ATOM   1759 C C    . ILE B 1 49  ? -16.86631 -4.46460  -7.53279  1.000 66.31382  ? 48  ILE B C    1 
ATOM   1760 O O    . ILE B 1 49  ? -15.70328 -4.08262  -7.39400  1.000 64.72410  ? 48  ILE B O    1 
ATOM   1761 C CB   . ILE B 1 49  ? -17.51016 -6.71261  -6.55871  1.000 46.59385  ? 48  ILE B CB   1 
ATOM   1762 C CG1  . ILE B 1 49  ? -18.00094 -7.43963  -5.30464  1.000 73.11619  ? 48  ILE B CG1  1 
ATOM   1763 C CG2  . ILE B 1 49  ? -16.12325 -7.17463  -6.97099  1.000 53.31862  ? 48  ILE B CG2  1 
ATOM   1764 C CD1  . ILE B 1 49  ? -17.73168 -6.69667  -4.02267  1.000 69.15871  ? 48  ILE B CD1  1 
ATOM   1765 N N    . LYS B 1 50  ? -17.59152 -4.26256  -8.62764  1.000 57.25517  ? 49  LYS B N    1 
ATOM   1766 C CA   . LYS B 1 50  ? -16.99074 -3.63055  -9.83174  1.000 64.16794  ? 49  LYS B CA   1 
ATOM   1767 C C    . LYS B 1 50  ? -16.60866 -2.19356  -9.50778  1.000 55.24151  ? 49  LYS B C    1 
ATOM   1768 O O    . LYS B 1 50  ? -15.43067 -1.86058  -9.61300  1.000 58.83920  ? 49  LYS B O    1 
ATOM   1769 C CB   . LYS B 1 50  ? -17.98196 -3.66950  -10.99455 1.000 63.44140  ? 49  LYS B CB   1 
ATOM   1770 C CG   . LYS B 1 50  ? -18.06413 -4.99749  -11.73457 1.000 75.72328  ? 49  LYS B CG   1 
ATOM   1771 C CD   . LYS B 1 50  ? -18.85437 -4.91744  -13.01842 1.000 81.02600  ? 49  LYS B CD   1 
ATOM   1772 C CE   . LYS B 1 50  ? -19.80043 -6.08442  -13.21226 1.000 90.63086  ? 49  LYS B CE   1 
ATOM   1773 N NZ   . LYS B 1 50  ? -19.50668 -6.83140  -14.45733 1.000 72.07181  ? 49  LYS B NZ   1 
ATOM   1774 N N    . LEU B 1 51  ? -17.59157 -1.38755  -9.13658  1.000 57.51702  ? 50  LEU B N    1 
ATOM   1775 C CA   . LEU B 1 51  ? -17.31947 0.01843   -8.75660  1.000 70.91060  ? 50  LEU B CA   1 
ATOM   1776 C C    . LEU B 1 51  ? -16.15428 0.04939   -7.76182  1.000 54.70198  ? 50  LEU B C    1 
ATOM   1777 O O    . LEU B 1 51  ? -15.26930 0.90038   -7.91397  1.000 61.72543  ? 50  LEU B O    1 
ATOM   1778 C CB   . LEU B 1 51  ? -18.58935 0.60744   -8.14634  1.000 68.31995  ? 50  LEU B CB   1 
ATOM   1779 C CG   . LEU B 1 51  ? -19.79053 0.66948   -9.08211  1.000 80.79480  ? 50  LEU B CG   1 
ATOM   1780 C CD1  . LEU B 1 51  ? -21.06837 0.97349   -8.31386  1.000 82.04167  ? 50  LEU B CD1  1 
ATOM   1781 C CD2  . LEU B 1 51  ? -19.56772 1.70050   -10.17713 1.000 72.49560  ? 50  LEU B CD2  1 
ATOM   1782 N N    . ASP B 1 52  ? -16.15812 -0.86663  -6.80484  1.000 42.08247  ? 51  ASP B N    1 
ATOM   1783 C CA   . ASP B 1 52  ? -15.10392 -0.85467  -5.77404  1.000 53.10425  ? 51  ASP B CA   1 
ATOM   1784 C C    . ASP B 1 52  ? -13.75405 -1.08068  -6.44431  1.000 55.68900  ? 51  ASP B C    1 
ATOM   1785 O O    . ASP B 1 52  ? -12.82599 -0.30270  -6.18147  1.000 59.02081  ? 51  ASP B O    1 
ATOM   1786 C CB   . ASP B 1 52  ? -15.38373 -1.90969  -4.71301  1.000 55.59690  ? 51  ASP B CB   1 
ATOM   1787 C CG   . ASP B 1 52  ? -14.17657 -2.12673  -3.83925  1.000 73.85482  ? 51  ASP B CG   1 
ATOM   1788 O OD1  . ASP B 1 52  ? -13.82342 -1.18375  -3.12529  1.000 56.10685  ? 51  ASP B OD1  1 
ATOM   1789 O OD2  . ASP B 1 52  ? -13.58960 -3.21874  -3.90638  1.000 74.85477  ? 51  ASP B OD2  1 
ATOM   1790 N N    . GLU B 1 53  ? -13.66023 -2.10566  -7.28235  1.000 54.91907  ? 52  GLU B N    1 
ATOM   1791 C CA   . GLU B 1 53  ? -12.38936 -2.43266  -7.96860  1.000 50.78059  ? 52  GLU B CA   1 
ATOM   1792 C C    . GLU B 1 53  ? -11.90550 -1.21365  -8.75766  1.000 52.45457  ? 52  GLU B C    1 
ATOM   1793 O O    . GLU B 1 53  ? -10.69551 -1.00967  -8.83789  1.000 57.12656  ? 52  GLU B O    1 
ATOM   1794 C CB   . GLU B 1 53  ? -12.62056 -3.62564  -8.88758  1.000 47.10075  ? 52  GLU B CB   1 
ATOM   1795 C CG   . GLU B 1 53  ? -12.87344 -4.92865  -8.15656  1.000 45.85902  ? 52  GLU B CG   1 
ATOM   1796 C CD   . GLU B 1 53  ? -13.03964 -6.11163  -9.09256  1.000 62.58594  ? 52  GLU B CD   1 
ATOM   1797 O OE1  . GLU B 1 53  ? -13.84982 -6.01159  -10.02940 1.000 53.96915  ? 52  GLU B OE1  1 
ATOM   1798 O OE2  . GLU B 1 53  ? -12.34662 -7.12164  -8.88771  1.000 65.31376  ? 52  GLU B OE2  1 
ATOM   1799 N N    . GLU B 1 54  ? -12.83059 -0.44163  -9.32147  1.000 38.02027  ? 53  GLU B N    1 
ATOM   1800 C CA   . GLU B 1 54  ? -12.48572 0.77139   -10.10051 1.000 57.41440  ? 53  GLU B CA   1 
ATOM   1801 C C    . GLU B 1 54  ? -11.85653 1.83735   -9.20560  1.000 56.28840  ? 53  GLU B C    1 
ATOM   1802 O O    . GLU B 1 54  ? -10.89860 2.46535   -9.64377  1.000 49.17720  ? 53  GLU B O    1 
ATOM   1803 C CB   . GLU B 1 54  ? -13.73683 1.36042   -10.73725 1.000 63.17155  ? 53  GLU B CB   1 
ATOM   1804 C CG   . GLU B 1 54  ? -13.89412 1.03446   -12.20823 1.000 78.29769  ? 53  GLU B CG   1 
ATOM   1805 C CD   . GLU B 1 54  ? -14.42826 2.17848   -13.05410 1.000 94.51255  ? 53  GLU B CD   1 
ATOM   1806 O OE1  . GLU B 1 54  ? -14.69414 3.26048   -12.49303 1.000 91.16576  ? 53  GLU B OE1  1 
ATOM   1807 O OE2  . GLU B 1 54  ? -14.56850 1.98551   -14.27708 1.000 83.84926  ? 53  GLU B OE2  1 
ATOM   1808 N N    . VAL B 1 55  ? -12.39130 2.02434   -7.99950  1.000 59.06406  ? 54  VAL B N    1 
ATOM   1809 C CA   . VAL B 1 55  ? -11.82310 3.02631   -7.05258  1.000 36.43412  ? 54  VAL B CA   1 
ATOM   1810 C C    . VAL B 1 55  ? -10.42003 2.56927   -6.67286  1.000 40.32437  ? 54  VAL B C    1 
ATOM   1811 O O    . VAL B 1 55  ? -9.52402  3.40726   -6.65501  1.000 46.28532  ? 54  VAL B O    1 
ATOM   1812 C CB   . VAL B 1 55  ? -12.72386 3.20229   -5.82141  1.000 58.08739  ? 54  VAL B CB   1 
ATOM   1813 C CG1  . VAL B 1 55  ? -11.99163 3.87925   -4.67453  1.000 38.56361  ? 54  VAL B CG1  1 
ATOM   1814 C CG2  . VAL B 1 55  ? -13.99991 3.95132   -6.16315  1.000 60.44151  ? 54  VAL B CG2  1 
ATOM   1815 N N    . MET B 1 56  ? -10.24900 1.27827   -6.40792  1.000 40.60945  ? 55  MET B N    1 
ATOM   1816 C CA   . MET B 1 56  ? -8.92394  0.74523   -6.00919  1.000 49.20967  ? 55  MET B CA   1 
ATOM   1817 C C    . MET B 1 56  ? -7.91615  0.97524   -7.13238  1.000 46.32553  ? 55  MET B C    1 
ATOM   1818 O O    . MET B 1 56  ? -6.78408  1.34022   -6.83159  1.000 52.39609  ? 55  MET B O    1 
ATOM   1819 C CB   . MET B 1 56  ? -8.99190  -0.74977  -5.70221  1.000 46.33942  ? 55  MET B CB   1 
ATOM   1820 C CG   . MET B 1 56  ? -7.68082  -1.30980  -5.20447  1.000 65.41335  ? 55  MET B CG   1 
ATOM   1821 S SD   . MET B 1 56  ? -7.07752  -0.44185  -3.73557  1.000 79.61866  ? 55  MET B SD   1 
ATOM   1822 C CE   . MET B 1 56  ? -8.35130  -0.87585  -2.55333  1.000 52.48093  ? 55  MET B CE   1 
ATOM   1823 N N    . LYS B 1 57  ? -8.33339  0.76228   -8.37530  1.000 50.40840  ? 56  LYS B N    1 
ATOM   1824 C CA   . LYS B 1 57  ? -7.43361  0.97729   -9.53647  1.000 53.92250  ? 56  LYS B CA   1 
ATOM   1825 C C    . LYS B 1 57  ? -7.05761  2.45929   -9.64851  1.000 40.23786  ? 56  LYS B C    1 
ATOM   1826 O O    . LYS B 1 57  ? -5.86461  2.74527   -9.72073  1.000 46.69301  ? 56  LYS B O    1 
ATOM   1827 C CB   . LYS B 1 57  ? -8.09886  0.47033   -10.81935 1.000 67.16940  ? 56  LYS B CB   1 
ATOM   1828 C CG   . LYS B 1 57  ? -8.68887  -0.93166  -10.76027 1.000 69.78062  ? 56  LYS B CG   1 
ATOM   1829 C CD   . LYS B 1 57  ? -7.65786  -2.02568  -10.60049 1.000 79.65799  ? 56  LYS B CD   1 
ATOM   1830 C CE   . LYS B 1 57  ? -8.23778  -3.31169  -10.05041 1.000 78.26163  ? 56  LYS B CE   1 
ATOM   1831 N NZ   . LYS B 1 57  ? -8.67951  -3.15971  -8.64432  1.000 64.31048  ? 56  LYS B NZ   1 
ATOM   1832 N N    . ARG B 1 58  ? -8.04160  3.34730   -9.67530  1.000 40.91127  ? 57  ARG B N    1 
ATOM   1833 C CA   . ARG B 1 58  ? -7.77258  4.80730   -9.71832  1.000 54.17587  ? 57  ARG B CA   1 
ATOM   1834 C C    . ARG B 1 58  ? -6.91734  5.21626   -8.51547  1.000 48.52426  ? 57  ARG B C    1 
ATOM   1835 O O    . ARG B 1 58  ? -6.01036  6.03625   -8.69363  1.000 41.57056  ? 57  ARG B O    1 
ATOM   1836 C CB   . ARG B 1 58  ? -9.08957  5.58032   -9.72005  1.000 42.30397  ? 57  ARG B CB   1 
ATOM   1837 C CG   . ARG B 1 58  ? -9.85982  5.50136   -11.02690 1.000 66.71576  ? 57  ARG B CG   1 
ATOM   1838 C CD   . ARG B 1 58  ? -9.93892  6.86738   -11.67286 1.000 74.35584  ? 57  ARG B CD   1 
ATOM   1839 N NE   . ARG B 1 58  ? -8.64192  7.52136   -11.71509 1.000 76.66415  ? 57  ARG B NE   1 
ATOM   1840 C CZ   . ARG B 1 58  ? -8.42783  8.77935   -11.35810 1.000 63.87009  ? 57  ARG B CZ   1 
ATOM   1841 N NH1  . ARG B 1 58  ? -9.42773  9.52635   -10.92989 1.000 79.44423  ? 57  ARG B NH1  1 
ATOM   1842 N NH2  . ARG B 1 58  ? -7.21184  9.29133   -11.43732 1.000 58.16591  ? 57  ARG B NH2  1 
ATOM   1843 N N    . SER B 1 59  ? -7.18713  4.64524   -7.34643  1.000 40.01683  ? 58  SER B N    1 
ATOM   1844 C CA   . SER B 1 59  ? -6.45988  5.03220   -6.10756  1.000 44.64172  ? 58  SER B CA   1 
ATOM   1845 C C    . SER B 1 59  ? -5.01690  4.53317   -6.15885  1.000 40.29860  ? 58  SER B C    1 
ATOM   1846 O O    . SER B 1 59  ? -4.14380  5.23815   -5.65700  1.000 44.24295  ? 58  SER B O    1 
ATOM   1847 C CB   . SER B 1 59  ? -7.19466  4.54518   -4.89843  1.000 44.37565  ? 58  SER B CB   1 
ATOM   1848 O OG   . SER B 1 59  ? -8.45063  5.19120   -4.78018  1.000 47.91014  ? 58  SER B OG   1 
ATOM   1849 N N    . GLU B 1 60  ? -4.79204  3.36818   -6.75892  1.000 46.67263  ? 59  GLU B N    1 
ATOM   1850 C CA   . GLU B 1 60  ? -3.41608  2.84716   -6.93420  1.000 44.70391  ? 59  GLU B CA   1 
ATOM   1851 C C    . GLU B 1 60  ? -2.67925  3.77317   -7.90532  1.000 38.68569  ? 59  GLU B C    1 
ATOM   1852 O O    . GLU B 1 60  ? -1.51420  4.09315   -7.64853  1.000 37.00527  ? 59  GLU B O    1 
ATOM   1853 C CB   . GLU B 1 60  ? -3.46021  1.41718   -7.47122  1.000 50.95737  ? 59  GLU B CB   1 
ATOM   1854 C CG   . GLU B 1 60  ? -3.75502  0.37916   -6.40819  1.000 71.68811  ? 59  GLU B CG   1 
ATOM   1855 C CD   . GLU B 1 60  ? -2.61984  0.13112   -5.43041  1.000 81.56655  ? 59  GLU B CD   1 
ATOM   1856 O OE1  . GLU B 1 60  ? -1.45891  0.33911   -5.81963  1.000 93.51643  ? 59  GLU B OE1  1 
ATOM   1857 O OE2  . GLU B 1 60  ? -2.90062  -0.26890  -4.28236  1.000 64.97752  ? 59  GLU B OE2  1 
ATOM   1858 N N    . GLU B 1 61  ? -3.36145  4.16921   -8.97218  1.000 34.83860  ? 60  GLU B N    1 
ATOM   1859 C CA   . GLU B 1 61  ? -2.76062  5.11022   -9.94627  1.000 50.31976  ? 60  GLU B CA   1 
ATOM   1860 C C    . GLU B 1 61  ? -2.34746  6.38720   -9.21432  1.000 42.05515  ? 60  GLU B C    1 
ATOM   1861 O O    . GLU B 1 61  ? -1.19048  6.80318   -9.35153  1.000 40.95761  ? 60  GLU B O    1 
ATOM   1862 C CB   . GLU B 1 61  ? -3.75982  5.46826   -11.04407 1.000 47.08414  ? 60  GLU B CB   1 
ATOM   1863 C CG   . GLU B 1 61  ? -4.13402  4.32029   -11.96303 1.000 79.55192  ? 60  GLU B CG   1 
ATOM   1864 C CD   . GLU B 1 61  ? -5.18421  4.69733   -12.99782 1.000 93.88192  ? 60  GLU B CD   1 
ATOM   1865 O OE1  . GLU B 1 61  ? -5.75717  5.79534   -12.87668 1.000 92.18192  ? 60  GLU B OE1  1 
ATOM   1866 O OE2  . GLU B 1 61  ? -5.43740  3.88735   -13.90579 1.000 95.80072  ? 60  GLU B OE2  1 
ATOM   1867 N N    . LEU B 1 62  ? -3.26330  6.94820   -8.43413  1.000 39.29732  ? 61  LEU B N    1 
ATOM   1868 C CA   . LEU B 1 62  ? -2.97715  8.23218   -7.75216  1.000 27.00650  ? 61  LEU B CA   1 
ATOM   1869 C C    . LEU B 1 62  ? -1.80396  8.06313   -6.77339  1.000 30.01069  ? 61  LEU B C    1 
ATOM   1870 O O    . LEU B 1 62  ? -0.96494  8.95912   -6.72153  1.000 31.34515  ? 61  LEU B O    1 
ATOM   1871 C CB   . LEU B 1 62  ? -4.27902  8.73218   -7.11790  1.000 30.13882  ? 61  LEU B CB   1 
ATOM   1872 C CG   . LEU B 1 62  ? -5.35920  9.13622   -8.11568  1.000 37.49473  ? 61  LEU B CG   1 
ATOM   1873 C CD1  . LEU B 1 62  ? -6.70607  9.28323   -7.43342  1.000 34.63027  ? 61  LEU B CD1  1 
ATOM   1874 C CD2  . LEU B 1 62  ? -4.98032  10.42623  -8.82273  1.000 36.99281  ? 61  LEU B CD2  1 
ATOM   1875 N N    . LEU B 1 63  ? -1.71085  6.91912   -6.09743  1.000 39.87078  ? 62  LEU B N    1 
ATOM   1876 C CA   . LEU B 1 63  ? -0.62766  6.69808   -5.10064  1.000 41.54622  ? 62  LEU B CA   1 
ATOM   1877 C C    . LEU B 1 63  ? 0.72220   6.64807   -5.80990  1.000 36.54586  ? 62  LEU B C    1 
ATOM   1878 O O    . LEU B 1 63  ? 1.69731   7.16204   -5.25908  1.000 41.21718  ? 62  LEU B O    1 
ATOM   1879 C CB   . LEU B 1 63  ? -0.85754  5.39406   -4.32963  1.000 44.53228  ? 62  LEU B CB   1 
ATOM   1880 C CG   . LEU B 1 63  ? 0.17466   5.10702   -3.24383  1.000 37.66684  ? 62  LEU B CG   1 
ATOM   1881 C CD1  . LEU B 1 63  ? 0.03890   6.09400   -2.09378  1.000 43.17684  ? 62  LEU B CD1  1 
ATOM   1882 C CD2  . LEU B 1 63  ? 0.05874   3.67901   -2.73684  1.000 66.28052  ? 62  LEU B CD2  1 
ATOM   1883 N N    . LYS B 1 64  ? 0.75396   6.01810   -6.97892  1.000 38.90971  ? 63  LYS B N    1 
ATOM   1884 C CA   . LYS B 1 64  ? 2.01382   5.89709   -7.74717  1.000 49.46789  ? 63  LYS B CA   1 
ATOM   1885 C C    . LYS B 1 64  ? 2.49077   7.29809   -8.13123  1.000 29.53096  ? 63  LYS B C    1 
ATOM   1886 O O    . LYS B 1 64  ? 3.67680   7.57307   -7.95645  1.000 34.99628  ? 63  LYS B O    1 
ATOM   1887 C CB   . LYS B 1 64  ? 1.75857   5.00912   -8.96914  1.000 44.88272  ? 63  LYS B CB   1 
ATOM   1888 N N    . ARG B 1 65  ? 1.58068   8.12612   -8.63903  1.000 32.21748  ? 64  ARG B N    1 
ATOM   1889 C CA   . ARG B 1 65  ? 1.92164   9.52312   -8.99007  1.000 38.40144  ? 64  ARG B CA   1 
ATOM   1890 C C    . ARG B 1 65  ? 2.44089   10.24509  -7.74715  1.000 41.41993  ? 64  ARG B C    1 
ATOM   1891 O O    . ARG B 1 65  ? 3.41288   10.98407  -7.87132  1.000 38.94047  ? 64  ARG B O    1 
ATOM   1892 C CB   . ARG B 1 65  ? 0.67355   10.23116  -9.51681  1.000 40.67206  ? 64  ARG B CB   1 
ATOM   1893 C CG   . ARG B 1 65  ? 0.41426   10.07619  -11.00477 1.000 42.49867  ? 64  ARG B CG   1 
ATOM   1894 C CD   . ARG B 1 65  ? -0.66180  11.05922  -11.42354 1.000 46.18103  ? 64  ARG B CD   1 
ATOM   1895 N NE   . ARG B 1 65  ? -0.16478  12.42321  -11.41460 1.000 46.51483  ? 64  ARG B NE   1 
ATOM   1896 C CZ   . ARG B 1 65  ? -0.92079  13.50423  -11.57143 1.000 42.29245  ? 64  ARG B CZ   1 
ATOM   1897 N NH1  . ARG B 1 65  ? -2.22283  13.38525  -11.74719 1.000 39.80527  ? 64  ARG B NH1  1 
ATOM   1898 N NH2  . ARG B 1 65  ? -0.36577  14.70022  -11.55051 1.000 45.16132  ? 64  ARG B NH2  1 
ATOM   1899 N N    . ALA B 1 66  ? 1.80410   10.01707  -6.60203  1.000 36.10331  ? 65  ALA B N    1 
ATOM   1900 C CA   . ALA B 1 66  ? 2.19735   10.69304  -5.34809  1.000 32.56589  ? 65  ALA B CA   1 
ATOM   1901 C C    . ALA B 1 66  ? 3.59643   10.25600  -4.91637  1.000 40.81575  ? 65  ALA B C    1 
ATOM   1902 O O    . ALA B 1 66  ? 4.34853   11.10998  -4.44650  1.000 36.18808  ? 65  ALA B O    1 
ATOM   1903 C CB   . ALA B 1 66  ? 1.18255   10.40303  -4.28191  1.000 38.53257  ? 65  ALA B CB   1 
ATOM   1904 N N    . GLU B 1 67  ? 3.91938   8.97700   -5.07746  1.000 32.26346  ? 66  GLU B N    1 
ATOM   1905 C CA   . GLU B 1 67  ? 5.24945   8.45497   -4.67773  1.000 33.38240  ? 66  GLU B CA   1 
ATOM   1906 C C    . GLU B 1 67  ? 6.32028   9.07797   -5.58192  1.000 30.69449  ? 66  GLU B C    1 
ATOM   1907 O O    . GLU B 1 67  ? 7.35239   9.49694   -5.05811  1.000 38.07384  ? 66  GLU B O    1 
ATOM   1908 C CB   . GLU B 1 67  ? 5.25142   6.92497   -4.70376  1.000 45.20020  ? 66  GLU B CB   1 
ATOM   1909 C CG   . GLU B 1 67  ? 4.27859   6.30197   -3.72159  1.000 50.93189  ? 66  GLU B CG   1 
ATOM   1910 C CD   . GLU B 1 67  ? 4.13756   4.78797   -3.77960  1.000 66.31374  ? 66  GLU B CD   1 
ATOM   1911 O OE1  . GLU B 1 67  ? 3.90134   4.25200   -4.87857  1.000 69.97645  ? 66  GLU B OE1  1 
ATOM   1912 O OE2  . GLU B 1 67  ? 4.25675   4.14994   -2.71664  1.000 61.40341  ? 66  GLU B OE2  1 
ATOM   1913 N N    . GLU B 1 68  ? 6.04904   9.17001   -6.87587  1.000 40.00219  ? 67  GLU B N    1 
ATOM   1914 C CA   . GLU B 1 68  ? 7.00086   9.79701   -7.82803  1.000 41.53763  ? 67  GLU B CA   1 
ATOM   1915 C C    . GLU B 1 68  ? 7.23496   11.25900  -7.43205  1.000 36.91761  ? 67  GLU B C    1 
ATOM   1916 O O    . GLU B 1 68  ? 8.38598   11.67698  -7.38626  1.000 38.84557  ? 67  GLU B O    1 
ATOM   1917 C CB   . GLU B 1 68  ? 6.40959   9.69105   -9.22792  1.000 42.06861  ? 67  GLU B CB   1 
ATOM   1918 C CG   . GLU B 1 68  ? 6.70645   10.88607  -10.11095 1.000 66.55704  ? 67  GLU B CG   1 
ATOM   1919 C CD   . GLU B 1 68  ? 8.09733   10.89506  -10.71822 1.000 57.61410  ? 67  GLU B CD   1 
ATOM   1920 O OE1  . GLU B 1 68  ? 8.85336   9.93904   -10.47539 1.000 70.74197  ? 67  GLU B OE1  1 
ATOM   1921 O OE2  . GLU B 1 68  ? 8.42021   11.85907  -11.43226 1.000 64.90949  ? 67  GLU B OE2  1 
ATOM   1922 N N    . LEU B 1 69  ? 6.16604   11.97501  -7.11982  1.000 33.59335  ? 68  LEU B N    1 
ATOM   1923 C CA   . LEU B 1 69  ? 6.27013   13.40900  -6.75681  1.000 45.72417  ? 68  LEU B CA   1 
ATOM   1924 C C    . LEU B 1 69  ? 7.01239   13.56996  -5.42195  1.000 33.18903  ? 68  LEU B C    1 
ATOM   1925 O O    . LEU B 1 69  ? 7.78443   14.51194  -5.30108  1.000 29.17682  ? 68  LEU B O    1 
ATOM   1926 C CB   . LEU B 1 69  ? 4.85315   13.98902  -6.71553  1.000 30.65227  ? 68  LEU B CB   1 
ATOM   1927 C CG   . LEU B 1 69  ? 4.22989   14.30706  -8.06840  1.000 44.53845  ? 68  LEU B CG   1 
ATOM   1928 C CD1  . LEU B 1 69  ? 2.72492   14.47409  -7.94111  1.000 38.08894  ? 68  LEU B CD1  1 
ATOM   1929 C CD2  . LEU B 1 69  ? 4.85580   15.55307  -8.66849  1.000 37.30730  ? 68  LEU B CD2  1 
ATOM   1930 N N    . LEU B 1 70  ? 6.79955   12.64794  -4.48093  1.000 38.56929  ? 69  LEU B N    1 
ATOM   1931 C CA   . LEU B 1 70  ? 7.50180   12.70190  -3.17406  1.000 35.37294  ? 69  LEU B CA   1 
ATOM   1932 C C    . LEU B 1 70  ? 9.00576   12.50488  -3.38836  1.000 41.99376  ? 69  LEU B C    1 
ATOM   1933 O O    . LEU B 1 70  ? 9.78089   13.21285  -2.76049  1.000 38.73915  ? 69  LEU B O    1 
ATOM   1934 C CB   . LEU B 1 70  ? 6.94596   11.63689  -2.23898  1.000 38.54420  ? 69  LEU B CB   1 
ATOM   1935 C CG   . LEU B 1 70  ? 7.59223   11.59585  -0.85311  1.000 42.63447  ? 69  LEU B CG   1 
ATOM   1936 C CD1  . LEU B 1 70  ? 7.35239   12.89883  -0.10803  1.000 39.83412  ? 69  LEU B CD1  1 
ATOM   1937 C CD2  . LEU B 1 70  ? 7.08537   10.41784  -0.04104  1.000 49.52945  ? 69  LEU B CD2  1 
ATOM   1938 N N    . ARG B 1 71  ? 9.39158   11.58689  -4.26745  1.000 42.11718  ? 70  ARG B N    1 
ATOM   1939 C CA   . ARG B 1 71  ? 10.82751  11.40288  -4.58173  1.000 41.81968  ? 70  ARG B CA   1 
ATOM   1940 C C    . ARG B 1 71  ? 11.39843  12.71188  -5.14181  1.000 29.85349  ? 70  ARG B C    1 
ATOM   1941 O O    . ARG B 1 71  ? 12.47951  13.10585  -4.71901  1.000 35.93943  ? 70  ARG B O    1 
ATOM   1942 C CB   . ARG B 1 71  ? 10.96931  10.23890  -5.56178  1.000 48.52775  ? 70  ARG B CB   1 
ATOM   1943 C CG   . ARG B 1 71  ? 10.56539  8.88789   -4.98874  1.000 65.13225  ? 70  ARG B CG   1 
ATOM   1944 C CD   . ARG B 1 71  ? 11.19222  7.75190   -5.77488  1.000 83.98278  ? 70  ARG B CD   1 
ATOM   1945 N NE   . ARG B 1 71  ? 10.79596  7.78194   -7.17481  1.000 68.64846  ? 70  ARG B NE   1 
ATOM   1946 C CZ   . ARG B 1 71  ? 9.67586   7.24996   -7.64660  1.000 78.22482  ? 70  ARG B CZ   1 
ATOM   1947 N NH1  . ARG B 1 71  ? 8.84000   6.63996   -6.82646  1.000 63.84985  ? 70  ARG B NH1  1 
ATOM   1948 N NH2  . ARG B 1 71  ? 9.39761   7.32500   -8.93555  1.000 71.29791  ? 70  ARG B NH2  1 
ATOM   1949 N N    . GLU B 1 72  ? 10.68026  13.34591  -6.06466  1.000 36.31485  ? 71  GLU B N    1 
ATOM   1950 C CA   . GLU B 1 72  ? 11.12017  14.63392  -6.66171  1.000 40.97646  ? 71  GLU B CA   1 
ATOM   1951 C C    . GLU B 1 72  ? 11.22039  15.72089  -5.58271  1.000 34.36211  ? 71  GLU B C    1 
ATOM   1952 O O    . GLU B 1 72  ? 12.18440  16.48788  -5.61588  1.000 39.84811  ? 71  GLU B O    1 
ATOM   1953 C CB   . GLU B 1 72  ? 10.15696  15.00896  -7.78452  1.000 36.99869  ? 71  GLU B CB   1 
ATOM   1954 C CG   . GLU B 1 72  ? 10.65780  16.11797  -8.68559  1.000 61.91428  ? 71  GLU B CG   1 
ATOM   1955 C CD   . GLU B 1 72  ? 9.67460   16.50301  -9.77539  1.000 50.16928  ? 71  GLU B CD   1 
ATOM   1956 O OE1  . GLU B 1 72  ? 8.67156   15.79303  -9.94122  1.000 51.87582  ? 71  GLU B OE1  1 
ATOM   1957 O OE2  . GLU B 1 72  ? 9.91749   17.51602  -10.45242 1.000 58.03161  ? 71  GLU B OE2  1 
ATOM   1958 N N    . LEU B 1 73  ? 10.26857  15.76489  -4.65353  1.000 36.43280  ? 72  LEU B N    1 
ATOM   1959 C CA   . LEU B 1 73  ? 10.30080  16.75186  -3.54751  1.000 33.44824  ? 72  LEU B CA   1 
ATOM   1960 C C    . LEU B 1 73  ? 11.53096  16.50282  -2.68475  1.000 30.94822  ? 72  LEU B C    1 
ATOM   1961 O O    . LEU B 1 73  ? 12.20404  17.46780  -2.33186  1.000 35.06985  ? 72  LEU B O    1 
ATOM   1962 C CB   . LEU B 1 73  ? 9.01995   16.60186  -2.72227  1.000 36.88451  ? 72  LEU B CB   1 
ATOM   1963 C CG   . LEU B 1 73  ? 8.91420   17.49784  -1.49123  1.000 44.17603  ? 72  LEU B CG   1 
ATOM   1964 C CD1  . LEU B 1 73  ? 8.90015   18.95985  -1.89819  1.000 54.45186  ? 72  LEU B CD1  1 
ATOM   1965 C CD2  . LEU B 1 73  ? 7.66835   17.15484  -0.69600  1.000 37.61747  ? 72  LEU B CD2  1 
ATOM   1966 N N    . GLU B 1 74  ? 11.81799  15.23981  -2.41583  1.000 32.49821  ? 73  GLU B N    1 
ATOM   1967 C CA   . GLU B 1 74  ? 12.96615  14.88977  -1.54906  1.000 41.49242  ? 73  GLU B CA   1 
ATOM   1968 C C    . GLU B 1 74  ? 14.27502  15.27177  -2.24230  1.000 37.02700  ? 73  GLU B C    1 
ATOM   1969 O O    . GLU B 1 74  ? 15.16716  15.79574  -1.57246  1.000 41.53152  ? 73  GLU B O    1 
ATOM   1970 C CB   . GLU B 1 74  ? 12.88919  13.40577  -1.19808  1.000 36.76114  ? 73  GLU B CB   1 
ATOM   1971 C CG   . GLU B 1 74  ? 11.60632  13.00777  -0.49984  1.000 48.04652  ? 73  GLU B CG   1 
ATOM   1972 C CD   . GLU B 1 74  ? 11.48134  11.51677  -0.25085  1.000 66.79081  ? 73  GLU B CD   1 
ATOM   1973 O OE1  . GLU B 1 74  ? 12.32647  10.97474  0.47697   1.000 75.22438  ? 73  GLU B OE1  1 
ATOM   1974 O OE2  . GLU B 1 74  ? 10.54223  10.90080  -0.78469  1.000 65.10322  ? 73  GLU B OE2  1 
ATOM   1975 N N    . GLU B 1 75  ? 14.35777  15.05480  -3.54632  1.000 35.65669  ? 74  GLU B N    1 
ATOM   1976 C CA   . GLU B 1 75  ? 15.57663  15.41079  -4.30755  1.000 44.95403  ? 74  GLU B CA   1 
ATOM   1977 C C    . GLU B 1 75  ? 15.77767  16.92679  -4.26055  1.000 34.37710  ? 74  GLU B C    1 
ATOM   1978 O O    . GLU B 1 75  ? 16.90972  17.35476  -4.02076  1.000 46.19375  ? 74  GLU B O    1 
ATOM   1979 C CB   . GLU B 1 75  ? 15.46235  14.90283  -5.73954  1.000 39.06091  ? 74  GLU B CB   1 
ATOM   1980 C CG   . GLU B 1 75  ? 16.55718  15.41983  -6.65174  1.000 54.34276  ? 74  GLU B CG   1 
ATOM   1981 C CD   . GLU B 1 75  ? 16.39590  14.99986  -8.10172  1.000 82.86123  ? 74  GLU B CD   1 
ATOM   1982 O OE1  . GLU B 1 75  ? 15.36683  14.38289  -8.42553  1.000 84.81795  ? 74  GLU B OE1  1 
ATOM   1983 O OE2  . GLU B 1 75  ? 17.30275  15.29087  -8.89888  1.000 79.90795  ? 74  GLU B OE2  1 
ATOM   1984 N N    . LEU B 1 76  ? 14.70964  17.69681  -4.43533  1.000 34.06100  ? 75  LEU B N    1 
ATOM   1985 C CA   . LEU B 1 76  ? 14.84366  19.17181  -4.49532  1.000 35.36359  ? 75  LEU B CA   1 
ATOM   1986 C C    . LEU B 1 76  ? 15.24993  19.72077  -3.12639  1.000 36.20867  ? 75  LEU B C    1 
ATOM   1987 O O    . LEU B 1 76  ? 16.04995  20.65176  -3.09452  1.000 42.73479  ? 75  LEU B O    1 
ATOM   1988 C CB   . LEU B 1 76  ? 13.51558  19.76384  -4.97106  1.000 42.57869  ? 75  LEU B CB   1 
ATOM   1989 C CG   . LEU B 1 76  ? 13.22829  19.67788  -6.46700  1.000 41.84894  ? 75  LEU B CG   1 
ATOM   1990 C CD1  . LEU B 1 76  ? 11.80824  20.12891  -6.75872  1.000 48.49422  ? 75  LEU B CD1  1 
ATOM   1991 C CD2  . LEU B 1 76  ? 14.21815  20.52188  -7.25317  1.000 46.59094  ? 75  LEU B CD2  1 
ATOM   1992 N N    . ILE B 1 77  ? 14.70312  19.16076  -2.05330  1.000 34.49946  ? 76  ILE B N    1 
ATOM   1993 C CA   . ILE B 1 77  ? 15.00740  19.66072  -0.68134  1.000 43.08193  ? 76  ILE B CA   1 
ATOM   1994 C C    . ILE B 1 77  ? 16.49345  19.41469  -0.38763  1.000 46.98606  ? 76  ILE B C    1 
ATOM   1995 O O    . ILE B 1 77  ? 17.12457  20.30567  0.18926   1.000 49.37133  ? 76  ILE B O    1 
ATOM   1996 C CB   . ILE B 1 77  ? 14.03558  19.05771  0.35983   1.000 38.32266  ? 76  ILE B CB   1 
ATOM   1997 C CG1  . ILE B 1 77  ? 12.61355  19.55674  0.11011   1.000 47.39973  ? 76  ILE B CG1  1 
ATOM   1998 C CG2  . ILE B 1 77  ? 14.47586  19.32867  1.78875   1.000 29.61101  ? 76  ILE B CG2  1 
ATOM   1999 C CD1  . ILE B 1 77  ? 11.55468  18.83374  0.89730   1.000 37.83268  ? 76  ILE B CD1  1 
ATOM   2000 N N    . ARG B 1 78  ? 17.03834  18.29269  -0.85976  1.000 46.79708  ? 77  ARG B N    1 
ATOM   2001 C CA   . ARG B 1 78  ? 18.46837  17.96866  -0.64805  1.000 46.13812  ? 77  ARG B CA   1 
ATOM   2002 C C    . ARG B 1 78  ? 19.32225  19.00166  -1.37619  1.000 44.83991  ? 77  ARG B C    1 
ATOM   2003 O O    . ARG B 1 78  ? 20.33837  19.41264  -0.81637  1.000 51.26925  ? 77  ARG B O    1 
ATOM   2004 C CB   . ARG B 1 78  ? 18.74625  16.55567  -1.16913  1.000 44.51616  ? 77  ARG B CB   1 
ATOM   2005 C CG   . ARG B 1 78  ? 18.67444  15.47165  -0.10614  1.000 54.58893  ? 77  ARG B CG   1 
ATOM   2006 C CD   . ARG B 1 78  ? 19.19331  14.14965  -0.62927  1.000 47.09935  ? 77  ARG B CD   1 
ATOM   2007 N NE   . ARG B 1 78  ? 18.09922  13.28968  -1.04208  1.000 55.63620  ? 77  ARG B NE   1 
ATOM   2008 C CZ   . ARG B 1 78  ? 17.82798  12.98671  -2.29903  1.000 49.92059  ? 77  ARG B CZ   1 
ATOM   2009 N NH1  . ARG B 1 78  ? 18.57580  13.47072  -3.27317  1.000 59.76218  ? 77  ARG B NH1  1 
ATOM   2010 N NH2  . ARG B 1 78  ? 16.80991  12.19773  -2.57886  1.000 52.25998  ? 77  ARG B NH2  1 
ATOM   2011 N N    . ARG B 1 79  ? 18.90503  19.39670  -2.56910  1.000 44.08288  ? 78  ARG B N    1 
ATOM   2012 C CA   . ARG B 1 79  ? 19.67689  20.35170  -3.39722  1.000 56.38246  ? 78  ARG B CA   1 
ATOM   2013 C C    . ARG B 1 79  ? 19.59402  21.76869  -2.81818  1.000 54.41952  ? 78  ARG B C    1 
ATOM   2014 O O    . ARG B 1 79  ? 20.58701  22.48968  -2.91635  1.000 55.78879  ? 78  ARG B O    1 
ATOM   2015 C CB   . ARG B 1 79  ? 19.13461  20.33575  -4.82512  1.000 46.15885  ? 78  ARG B CB   1 
ATOM   2016 C CG   . ARG B 1 79  ? 19.09847  18.95176  -5.45914  1.000 79.53562  ? 78  ARG B CG   1 
ATOM   2017 C CD   . ARG B 1 79  ? 20.31230  18.69676  -6.33038  1.000 79.13090  ? 78  ARG B CD   1 
ATOM   2018 N NE   . ARG B 1 79  ? 20.37719  17.32277  -6.80243  1.000 78.34137  ? 78  ARG B NE   1 
ATOM   2019 C CZ   . ARG B 1 79  ? 19.72098  16.85980  -7.85831  1.000 93.99366  ? 78  ARG B CZ   1 
ATOM   2020 N NH1  . ARG B 1 79  ? 18.93685  17.66083  -8.55614  1.000 82.25849  ? 78  ARG B NH1  1 
ATOM   2021 N NH2  . ARG B 1 79  ? 19.85289  15.59381  -8.20936  1.000 84.46726  ? 78  ARG B NH2  1 
ATOM   2022 N N    . ILE B 1 80  ? 18.44913  22.14570  -2.25595  1.000 46.45442  ? 79  ILE B N    1 
ATOM   2023 C CA   . ILE B 1 80  ? 18.27625  23.54369  -1.77488  1.000 38.50854  ? 79  ILE B CA   1 
ATOM   2024 C C    . ILE B 1 80  ? 19.12249  23.76865  -0.52104  1.000 55.93766  ? 79  ILE B C    1 
ATOM   2025 O O    . ILE B 1 80  ? 18.95167  23.02663  0.44598   1.000 44.79623  ? 79  ILE B O    1 
ATOM   2026 C CB   . ILE B 1 80  ? 16.79330  23.89471  -1.56059  1.000 41.53981  ? 79  ILE B CB   1 
ATOM   2027 C CG1  . ILE B 1 80  ? 16.02104  23.86475  -2.88144  1.000 46.15425  ? 79  ILE B CG1  1 
ATOM   2028 C CG2  . ILE B 1 80  ? 16.65545  25.23370  -0.85653  1.000 41.83672  ? 79  ILE B CG2  1 
ATOM   2029 C CD1  . ILE B 1 80  ? 14.56207  23.52777  -2.73317  1.000 53.15010  ? 79  ILE B CD1  1 
ATOM   2030 N N    . PRO B 1 81  ? 20.01051  24.78063  -0.52219  1.000 52.56242  ? 80  PRO B N    1 
ATOM   2031 C CA   . PRO B 1 81  ? 20.85174  25.10259  0.63166   1.000 49.32661  ? 80  PRO B CA   1 
ATOM   2032 C C    . PRO B 1 81  ? 20.05798  25.59458  1.84582   1.000 53.81142  ? 80  PRO B C    1 
ATOM   2033 O O    . PRO B 1 81  ? 20.30608  26.68157  2.29780   1.000 53.73973  ? 80  PRO B O    1 
ATOM   2034 C CB   . PRO B 1 81  ? 21.72665  26.23159  0.07652   1.000 51.60221  ? 80  PRO B CB   1 
ATOM   2035 C CG   . PRO B 1 81  ? 20.90645  26.84963  -1.01131  1.000 62.16564  ? 80  PRO B CG   1 
ATOM   2036 C CD   . PRO B 1 81  ? 20.25131  25.66066  -1.66321  1.000 58.54185  ? 80  PRO B CD   1 
ATOM   2037 N N    . PHE B 1 82  ? 19.16206  24.76158  2.36498   1.000 49.29359  ? 81  PHE B N    1 
ATOM   2038 C CA   . PHE B 1 82  ? 18.29729  25.15857  3.50015   1.000 45.92499  ? 81  PHE B CA   1 
ATOM   2039 C C    . PHE B 1 82  ? 19.10153  25.24953  4.79000   1.000 54.23860  ? 81  PHE B C    1 
ATOM   2040 O O    . PHE B 1 82  ? 20.16654  24.63051  4.87478   1.000 55.72537  ? 81  PHE B O    1 
ATOM   2041 C CB   . PHE B 1 82  ? 17.16631  24.14359  3.69734   1.000 42.10143  ? 81  PHE B CB   1 
ATOM   2042 C CG   . PHE B 1 82  ? 15.99513  24.25763  2.75857   1.000 46.28505  ? 81  PHE B CG   1 
ATOM   2043 C CD1  . PHE B 1 82  ? 15.19615  25.38564  2.75475   1.000 41.68141  ? 81  PHE B CD1  1 
ATOM   2044 C CD2  . PHE B 1 82  ? 15.67495  23.22265  1.89861   1.000 37.78832  ? 81  PHE B CD2  1 
ATOM   2045 C CE1  . PHE B 1 82  ? 14.11298  25.48268  1.89596   1.000 35.08689  ? 81  PHE B CE1  1 
ATOM   2046 C CE2  . PHE B 1 82  ? 14.58979  23.31769  1.04482   1.000 31.81692  ? 81  PHE B CE2  1 
ATOM   2047 C CZ   . PHE B 1 82  ? 13.81380  24.44870  1.04399   1.000 29.23567  ? 81  PHE B CZ   1 
ATOM   2048 N N    . SER B 1 83  ? 18.57973  25.98752  5.76811   1.000 51.27648  ? 82  SER B N    1 
ATOM   2049 C CA   . SER B 1 83  ? 19.22799  26.06548  7.09599   1.000 60.76829  ? 82  SER B CA   1 
ATOM   2050 C C    . SER B 1 83  ? 19.12210  24.70546  7.77598   1.000 62.04056  ? 82  SER B C    1 
ATOM   2051 O O    . SER B 1 83  ? 18.18703  23.96248  7.46714   1.000 55.73070  ? 82  SER B O    1 
ATOM   2052 C CB   . SER B 1 83  ? 18.58917  27.12147  7.94714   1.000 49.41619  ? 82  SER B CB   1 
ATOM   2053 O OG   . SER B 1 83  ? 17.44929  26.62147  8.62434   1.000 55.87034  ? 82  SER B OG   1 
ATOM   2054 N N    . GLU B 1 84  ? 20.03727  24.42443  8.69680   1.000 65.28043  ? 83  GLU B N    1 
ATOM   2055 C CA   . GLU B 1 84  ? 20.04238  23.12041  9.40377   1.000 71.25977  ? 83  GLU B CA   1 
ATOM   2056 C C    . GLU B 1 84  ? 18.69351  22.91942  10.09102  1.000 62.23345  ? 83  GLU B C    1 
ATOM   2057 O O    . GLU B 1 84  ? 18.12347  21.84443  9.94611   1.000 56.59478  ? 83  GLU B O    1 
ATOM   2058 C CB   . GLU B 1 84  ? 21.19957  23.09337  10.39555  1.000 73.78076  ? 83  GLU B CB   1 
ATOM   2059 C CG   . GLU B 1 84  ? 22.53245  22.75836  9.75828   1.000 89.10279  ? 83  GLU B CG   1 
ATOM   2060 C CD   . GLU B 1 84  ? 22.91023  23.62538  8.57123   1.000 96.68759  ? 83  GLU B CD   1 
ATOM   2061 O OE1  . GLU B 1 84  ? 23.36129  24.76637  8.78817   1.000 92.90626  ? 83  GLU B OE1  1 
ATOM   2062 O OE2  . GLU B 1 84  ? 22.74601  23.15841  7.42725   1.000 95.15596  ? 83  GLU B OE2  1 
ATOM   2063 N N    . GLU B 1 85  ? 18.20266  23.94641  10.77714  1.000 52.62040  ? 84  GLU B N    1 
ATOM   2064 C CA   . GLU B 1 85  ? 16.92980  23.83341  11.52138  1.000 52.02759  ? 84  GLU B CA   1 
ATOM   2065 C C    . GLU B 1 85  ? 15.78461  23.52445  10.55659  1.000 51.97921  ? 84  GLU B C    1 
ATOM   2066 O O    . GLU B 1 85  ? 14.96966  22.65446  10.87573  1.000 64.94773  ? 84  GLU B O    1 
ATOM   2067 C CB   . GLU B 1 85  ? 16.64497  25.13240  12.27547  1.000 65.78595  ? 84  GLU B CB   1 
ATOM   2068 C CG   . GLU B 1 85  ? 15.16999  25.46842  12.37576  1.000 74.78382  ? 84  GLU B CG   1 
ATOM   2069 C CD   . GLU B 1 85  ? 14.86716  26.73241  13.15784  1.000 89.08117  ? 84  GLU B CD   1 
ATOM   2070 O OE1  . GLU B 1 85  ? 15.34938  26.85038  14.29875  1.000 88.82414  ? 84  GLU B OE1  1 
ATOM   2071 O OE2  . GLU B 1 85  ? 14.15007  27.59943  12.62300  1.000 79.68164  ? 84  GLU B OE2  1 
ATOM   2072 N N    . ILE B 1 86  ? 15.72441  24.23648  9.44262   1.000 46.42839  ? 85  ILE B N    1 
ATOM   2073 C CA   . ILE B 1 86  ? 14.58923  24.03752  8.50783   1.000 42.81937  ? 85  ILE B CA   1 
ATOM   2074 C C    . ILE B 1 86  ? 14.72610  22.62653  7.94578   1.000 34.79842  ? 85  ILE B C    1 
ATOM   2075 O O    . ILE B 1 86  ? 13.71706  21.93855  7.83795   1.000 43.82611  ? 85  ILE B O    1 
ATOM   2076 C CB   . ILE B 1 86  ? 14.57803  25.10455  7.39886   1.000 50.16512  ? 85  ILE B CB   1 
ATOM   2077 C CG1  . ILE B 1 86  ? 14.27916  26.49454  7.97095   1.000 42.99384  ? 85  ILE B CG1  1 
ATOM   2078 C CG2  . ILE B 1 86  ? 13.61081  24.73359  6.29004   1.000 34.20432  ? 85  ILE B CG2  1 
ATOM   2079 C CD1  . ILE B 1 86  ? 12.96331  26.57954  8.70520   1.000 50.37030  ? 85  ILE B CD1  1 
ATOM   2080 N N    . ARG B 1 87  ? 15.95703  22.23752  7.64353   1.000 38.29413  ? 86  ARG B N    1 
ATOM   2081 C CA   . ARG B 1 87  ? 16.20090  20.89753  7.06846   1.000 51.84476  ? 86  ARG B CA   1 
ATOM   2082 C C    . ARG B 1 87  ? 15.67007  19.84151  8.03553   1.000 40.05658  ? 86  ARG B C    1 
ATOM   2083 O O    . ARG B 1 87  ? 15.03196  18.89853  7.57163   1.000 44.18349  ? 86  ARG B O    1 
ATOM   2084 C CB   . ARG B 1 87  ? 17.67983  20.69451  6.74317   1.000 55.16220  ? 86  ARG B CB   1 
ATOM   2085 C CG   . ARG B 1 87  ? 17.90962  19.58353  5.73010   1.000 65.21949  ? 86  ARG B CG   1 
ATOM   2086 C CD   . ARG B 1 87  ? 19.34153  19.44452  5.26082   1.000 62.03512  ? 86  ARG B CD   1 
ATOM   2087 N NE   . ARG B 1 87  ? 19.73235  20.42253  4.25577   1.000 63.62001  ? 86  ARG B NE   1 
ATOM   2088 C CZ   . ARG B 1 87  ? 19.24912  20.48457  3.01986   1.000 55.34504  ? 86  ARG B CZ   1 
ATOM   2089 N NH1  . ARG B 1 87  ? 18.33703  19.62559  2.61102   1.000 46.07665  ? 86  ARG B NH1  1 
ATOM   2090 N NH2  . ARG B 1 87  ? 19.68798  21.41558  2.19880   1.000 64.47284  ? 86  ARG B NH2  1 
ATOM   2091 N N    . ARG B 1 88  ? 15.88732  20.04348  9.32850   1.000 50.21363  ? 87  ARG B N    1 
ATOM   2092 C CA   . ARG B 1 88  ? 15.44050  19.06546  10.34956  1.000 49.29926  ? 87  ARG B CA   1 
ATOM   2093 C C    . ARG B 1 88  ? 13.91849  18.98849  10.34285  1.000 49.29337  ? 87  ARG B C    1 
ATOM   2094 O O    . ARG B 1 88  ? 13.39346  17.88850  10.23192  1.000 36.90357  ? 87  ARG B O    1 
ATOM   2095 C CB   . ARG B 1 88  ? 15.97877  19.48343  11.72047  1.000 64.97772  ? 87  ARG B CB   1 
ATOM   2096 C CG   . ARG B 1 88  ? 15.08798  19.10541  12.89163  1.000 61.99454  ? 87  ARG B CG   1 
ATOM   2097 C CD   . ARG B 1 88  ? 15.73124  19.48637  14.21151  1.000 76.01671  ? 87  ARG B CD   1 
ATOM   2098 N NE   . ARG B 1 88  ? 14.97245  18.96336  15.33665  1.000 84.44786  ? 87  ARG B NE   1 
ATOM   2099 C CZ   . ARG B 1 88  ? 15.08352  17.72635  15.80360  1.000 84.28319  ? 87  ARG B CZ   1 
ATOM   2100 N NH1  . ARG B 1 88  ? 15.93040  16.88235  15.24542  1.000 69.39429  ? 87  ARG B NH1  1 
ATOM   2101 N NH2  . ARG B 1 88  ? 14.34671  17.34134  16.83173  1.000 85.73907  ? 87  ARG B NH2  1 
ATOM   2102 N N    . GLU B 1 89  ? 13.26153  20.13850  10.42800  1.000 37.64485  ? 88  GLU B N    1 
ATOM   2103 C CA   . GLU B 1 89  ? 11.78253  20.16752  10.41628  1.000 39.78048  ? 88  GLU B CA   1 
ATOM   2104 C C    . GLU B 1 89  ? 11.26828  19.47056  9.15537   1.000 34.04103  ? 88  GLU B C    1 
ATOM   2105 O O    . GLU B 1 89  ? 10.41728  18.59457  9.27751   1.000 42.73684  ? 88  GLU B O    1 
ATOM   2106 C CB   . GLU B 1 89  ? 11.30156  21.61253  10.48141  1.000 39.26863  ? 88  GLU B CB   1 
ATOM   2107 C CG   . GLU B 1 89  ? 11.90180  22.39349  11.62931  1.000 59.02309  ? 88  GLU B CG   1 
ATOM   2108 C CD   . GLU B 1 89  ? 11.62481  23.88450  11.59140  1.000 74.49755  ? 88  GLU B CD   1 
ATOM   2109 O OE1  . GLU B 1 89  ? 11.01063  24.33953  10.61253  1.000 60.74231  ? 88  GLU B OE1  1 
ATOM   2110 O OE2  . GLU B 1 89  ? 12.01901  24.57747  12.53734  1.000 87.45438  ? 88  GLU B OE2  1 
ATOM   2111 N N    . LEU B 1 90  ? 11.79106  19.85558  7.99328   1.000 30.75110  ? 89  LEU B N    1 
ATOM   2112 C CA   . LEU B 1 90  ? 11.34680  19.24561  6.71735   1.000 34.14984  ? 89  LEU B CA   1 
ATOM   2113 C C    . LEU B 1 90  ? 11.52779  17.72761  6.79328   1.000 36.11540  ? 89  LEU B C    1 
ATOM   2114 O O    . LEU B 1 90  ? 10.58172  17.02263  6.45944   1.000 41.06342  ? 89  LEU B O    1 
ATOM   2115 C CB   . LEU B 1 90  ? 12.17660  19.85063  5.57920   1.000 33.41701  ? 89  LEU B CB   1 
ATOM   2116 C CG   . LEU B 1 90  ? 11.95457  21.33164  5.29128   1.000 34.05885  ? 89  LEU B CG   1 
ATOM   2117 C CD1  . LEU B 1 90  ? 12.90037  21.81164  4.20511   1.000 35.77840  ? 89  LEU B CD1  1 
ATOM   2118 C CD2  . LEU B 1 90  ? 10.51549  21.59567  4.89656   1.000 32.96770  ? 89  LEU B CD2  1 
ATOM   2119 N N    . GLU B 1 91  ? 12.68887  17.27058  7.24905   1.000 41.47393  ? 90  GLU B N    1 
ATOM   2120 C CA   . GLU B 1 91  ? 13.00886  15.82057  7.30995   1.000 48.41607  ? 90  GLU B CA   1 
ATOM   2121 C C    . GLU B 1 91  ? 12.04103  15.09157  8.24612   1.000 38.70470  ? 90  GLU B C    1 
ATOM   2122 O O    . GLU B 1 91  ? 11.64495  13.97858  7.91617   1.000 38.66133  ? 90  GLU B O    1 
ATOM   2123 C CB   . GLU B 1 91  ? 14.46994  15.64854  7.71467   1.000 46.46557  ? 90  GLU B CB   1 
ATOM   2124 C CG   . GLU B 1 91  ? 15.43572  15.87055  6.56949   1.000 48.95232  ? 90  GLU B CG   1 
ATOM   2125 C CD   . GLU B 1 91  ? 16.88081  16.05052  6.99622   1.000 65.30728  ? 90  GLU B CD   1 
ATOM   2126 O OE1  . GLU B 1 91  ? 17.11604  16.30049  8.19118   1.000 71.12025  ? 90  GLU B OE1  1 
ATOM   2127 O OE2  . GLU B 1 91  ? 17.76864  15.93752  6.13004   1.000 73.49099  ? 90  GLU B OE2  1 
ATOM   2128 N N    . GLU B 1 92  ? 11.63225  15.72055  9.33921   1.000 45.49024  ? 91  GLU B N    1 
ATOM   2129 C CA   . GLU B 1 92  ? 10.63541  15.09155  10.24039  1.000 41.41557  ? 91  GLU B CA   1 
ATOM   2130 C C    . GLU B 1 92  ? 9.30627   14.85858  9.50364   1.000 42.46519  ? 91  GLU B C    1 
ATOM   2131 O O    . GLU B 1 92  ? 8.77427   13.74559  9.61772   1.000 39.82094  ? 91  GLU B O    1 
ATOM   2132 C CB   . GLU B 1 92  ? 10.46366  15.95252  11.49044  1.000 38.55751  ? 91  GLU B CB   1 
ATOM   2133 C CG   . GLU B 1 92  ? 11.76978  16.46649  12.05720  1.000 56.00884  ? 91  GLU B CG   1 
ATOM   2134 C CD   . GLU B 1 92  ? 11.68006  17.08746  13.44223  1.000 76.53844  ? 91  GLU B CD   1 
ATOM   2135 O OE1  . GLU B 1 92  ? 10.87511  18.02547  13.61941  1.000 62.47690  ? 91  GLU B OE1  1 
ATOM   2136 O OE2  . GLU B 1 92  ? 12.41722  16.63842  14.33608  1.000 81.53390  ? 91  GLU B OE2  1 
ATOM   2137 N N    . ILE B 1 93  ? 8.80614   15.85361  8.76676   1.000 32.43579  ? 92  ILE B N    1 
ATOM   2138 C CA   . ILE B 1 93  ? 7.49801   15.72265  8.07000   1.000 31.62549  ? 92  ILE B CA   1 
ATOM   2139 C C    . ILE B 1 93  ? 7.62577   14.70167  6.93896   1.000 29.29842  ? 92  ILE B C    1 
ATOM   2140 O O    . ILE B 1 93  ? 6.70373   13.90869  6.76812   1.000 34.04143  ? 92  ILE B O    1 
ATOM   2141 C CB   . ILE B 1 93  ? 7.01793   17.08967  7.55013   1.000 40.99976  ? 92  ILE B CB   1 
ATOM   2142 C CG1  . ILE B 1 93  ? 6.69716   18.04765  8.69921   1.000 44.04102  ? 92  ILE B CG1  1 
ATOM   2143 C CG2  . ILE B 1 93  ? 5.85174   16.93271  6.59435   1.000 45.72426  ? 92  ILE B CG2  1 
ATOM   2144 C CD1  . ILE B 1 93  ? 6.47811   19.47166  8.26928   1.000 61.24623  ? 92  ILE B CD1  1 
ATOM   2145 N N    . LEU B 1 94  ? 8.72763   14.74467  6.19975   1.000 29.93653  ? 93  LEU B N    1 
ATOM   2146 C CA   . LEU B 1 94  ? 8.94040   13.81469  5.06769   1.000 28.15531  ? 93  LEU B CA   1 
ATOM   2147 C C    . LEU B 1 94  ? 8.96148   12.38268  5.60565   1.000 25.18540  ? 93  LEU B C    1 
ATOM   2148 O O    . LEU B 1 94  ? 8.35934   11.52070  4.97575   1.000 38.57118  ? 93  LEU B O    1 
ATOM   2149 C CB   . LEU B 1 94  ? 10.25227  14.19868  4.37544   1.000 26.48582  ? 93  LEU B CB   1 
ATOM   2150 C CG   . LEU B 1 94  ? 10.22815  15.52470  3.62348   1.000 49.93635  ? 93  LEU B CG   1 
ATOM   2151 C CD1  . LEU B 1 94  ? 11.59805  15.84569  3.05222   1.000 41.30274  ? 93  LEU B CD1  1 
ATOM   2152 C CD2  . LEU B 1 94  ? 9.18394   15.50274  2.52168   1.000 37.98517  ? 93  LEU B CD2  1 
ATOM   2153 N N    . ARG B 1 95  ? 9.59569   12.16964  6.75252   1.000 37.69920  ? 94  ARG B N    1 
ATOM   2154 C CA   . ARG B 1 95  ? 9.62380   10.83163  7.39849   1.000 43.39961  ? 94  ARG B CA   1 
ATOM   2155 C C    . ARG B 1 95  ? 8.19185   10.37064  7.70175   1.000 33.60753  ? 94  ARG B C    1 
ATOM   2156 O O    . ARG B 1 95  ? 7.87577   9.21866   7.41579   1.000 37.21929  ? 94  ARG B O    1 
ATOM   2157 C CB   . ARG B 1 95  ? 10.48304  10.90858  8.66232   1.000 49.15383  ? 94  ARG B CB   1 
ATOM   2158 C CG   . ARG B 1 95  ? 10.84313  9.56256   9.26923   1.000 63.50084  ? 94  ARG B CG   1 
ATOM   2159 C CD   . ARG B 1 95  ? 11.89634  9.69752   10.35003  1.000 70.12934  ? 94  ARG B CD   1 
ATOM   2160 N NE   . ARG B 1 95  ? 11.59454  10.74651  11.31211  1.000 74.40363  ? 94  ARG B NE   1 
ATOM   2161 C CZ   . ARG B 1 95  ? 12.49666  11.56148  11.83795  1.000 79.38314  ? 94  ARG B CZ   1 
ATOM   2162 N NH1  . ARG B 1 95  ? 13.76659  11.45147  11.49071  1.000 80.34371  ? 94  ARG B NH1  1 
ATOM   2163 N NH2  . ARG B 1 95  ? 12.12984  12.48247  12.71005  1.000 59.56618  ? 94  ARG B NH2  1 
ATOM   2164 N N    . ARG B 1 96  ? 7.35496   11.26565  8.21893   1.000 29.87902  ? 95  ARG B N    1 
ATOM   2165 C CA   . ARG B 1 96  ? 5.95702   10.91566  8.57219   1.000 39.04668  ? 95  ARG B CA   1 
ATOM   2166 C C    . ARG B 1 96  ? 5.11878   10.63870  7.31935   1.000 29.00906  ? 95  ARG B C    1 
ATOM   2167 O O    . ARG B 1 96  ? 4.30977   9.71872   7.36148   1.000 30.02430  ? 95  ARG B O    1 
ATOM   2168 C CB   . ARG B 1 96  ? 5.33021   12.01765  9.43034   1.000 30.25826  ? 95  ARG B CB   1 
ATOM   2169 C CG   . ARG B 1 96  ? 4.40641   11.50964  10.52550  1.000 27.89380  ? 95  ARG B CG   1 
ATOM   2170 C CD   . ARG B 1 96  ? 3.71456   12.64864  11.24466  1.000 34.24396  ? 95  ARG B CD   1 
ATOM   2171 N NE   . ARG B 1 96  ? 2.38164   12.25365  11.66391  1.000 31.11968  ? 95  ARG B NE   1 
ATOM   2172 C CZ   . ARG B 1 96  ? 1.51977   13.04065  12.28509  1.000 34.04640  ? 95  ARG B CZ   1 
ATOM   2173 N NH1  . ARG B 1 96  ? 1.84784   14.28964  12.56005  1.000 30.99862  ? 95  ARG B NH1  1 
ATOM   2174 N NH2  . ARG B 1 96  ? 0.33183   12.57166  12.62231  1.000 29.02097  ? 95  ARG B NH2  1 
ATOM   2175 N N    . LEU B 1 97  ? 5.30759   11.42772  6.26433   1.000 33.07382  ? 96  LEU B N    1 
ATOM   2176 C CA   . LEU B 1 97  ? 4.54434   11.22876  5.00547   1.000 29.05596  ? 96  LEU B CA   1 
ATOM   2177 C C    . LEU B 1 97  ? 4.91221   9.86977   4.40937   1.000 27.39096  ? 96  LEU B C    1 
ATOM   2178 O O    . LEU B 1 97  ? 4.02810   9.21580   3.88652   1.000 34.29025  ? 96  LEU B O    1 
ATOM   2179 C CB   . LEU B 1 97  ? 4.85618   12.36378  4.03043   1.000 34.50155  ? 96  LEU B CB   1 
ATOM   2180 C CG   . LEU B 1 97  ? 4.14725   13.68679  4.30760   1.000 42.73825  ? 96  LEU B CG   1 
ATOM   2181 C CD1  . LEU B 1 97  ? 4.92116   14.84479  3.70648   1.000 52.24567  ? 96  LEU B CD1  1 
ATOM   2182 C CD2  . LEU B 1 97  ? 2.72515   13.65682  3.77187   1.000 33.72728  ? 96  LEU B CD2  1 
ATOM   2183 N N    . LYS B 1 98  ? 6.18322   9.49675   4.49512   1.000 21.80156  ? 97  LYS B N    1 
ATOM   2184 C CA   . LYS B 1 98  ? 6.63210   8.18175   3.98300   1.000 40.46942  ? 97  LYS B CA   1 
ATOM   2185 C C    . LYS B 1 98  ? 5.97224   7.08075   4.81910   1.000 32.91607  ? 97  LYS B C    1 
ATOM   2186 O O    . LYS B 1 98  ? 5.51011   6.09577   4.24217   1.000 32.56518  ? 97  LYS B O    1 
ATOM   2187 C CB   . LYS B 1 98  ? 8.16010   8.12473   3.97671   1.000 43.09253  ? 97  LYS B CB   1 
ATOM   2188 C CG   . LYS B 1 98  ? 8.82789   8.86074   2.82460   1.000 56.99232  ? 97  LYS B CG   1 
ATOM   2189 C CD   . LYS B 1 98  ? 10.00599  9.70071   3.26339   1.000 60.11770  ? 97  LYS B CD   1 
ATOM   2190 C CE   . LYS B 1 98  ? 11.32887  9.22270   2.70712   1.000 59.38465  ? 97  LYS B CE   1 
ATOM   2191 N NZ   . LYS B 1 98  ? 12.46904  9.69667   3.52392   1.000 63.85177  ? 97  LYS B NZ   1 
ATOM   2192 N N    . GLU B 1 99  ? 5.87850   7.29972   6.12813   1.000 33.86418  ? 98  GLU B N    1 
ATOM   2193 C CA   . GLU B 1 99  ? 5.18465   6.32471   7.00824   1.000 32.15738  ? 98  GLU B CA   1 
ATOM   2194 C C    . GLU B 1 99  ? 3.71557   6.21474   6.58951   1.000 32.79139  ? 98  GLU B C    1 
ATOM   2195 O O    . GLU B 1 99  ? 3.21853   5.08875   6.51458   1.000 35.78929  ? 98  GLU B O    1 
ATOM   2196 C CB   . GLU B 1 99  ? 5.33093   6.72867   8.47122   1.000 24.32207  ? 98  GLU B CB   1 
ATOM   2197 C CG   . GLU B 1 99  ? 4.42410   5.94567   9.40037   1.000 39.90578  ? 98  GLU B CG   1 
ATOM   2198 C CD   . GLU B 1 99  ? 4.75209   4.46566   9.46928   1.000 37.68017  ? 98  GLU B CD   1 
ATOM   2199 O OE1  . GLU B 1 99  ? 5.92605   4.11565   9.30104   1.000 45.53505  ? 98  GLU B OE1  1 
ATOM   2200 O OE2  . GLU B 1 99  ? 3.83012   3.67167   9.69144   1.000 42.00391  ? 98  GLU B OE2  1 
ATOM   2201 N N    . LEU B 1 100 ? 3.07952   7.33776   6.27166   1.000 28.42998  ? 99  LEU B N    1 
ATOM   2202 C CA   . LEU B 1 100 ? 1.64245   7.34579   5.90194   1.000 30.85933  ? 99  LEU B CA   1 
ATOM   2203 C C    . LEU B 1 100 ? 1.43118   6.73183   4.50596   1.000 30.39346  ? 99  LEU B C    1 
ATOM   2204 O O    . LEU B 1 100 ? 0.47213   5.97885   4.35513   1.000 29.85769  ? 99  LEU B O    1 
ATOM   2205 C CB   . LEU B 1 100 ? 1.13750   8.78280   6.00407   1.000 27.74167  ? 99  LEU B CB   1 
ATOM   2206 C CG   . LEU B 1 100 ? 0.99478   9.31677   7.42611   1.000 34.18906  ? 99  LEU B CG   1 
ATOM   2207 C CD1  . LEU B 1 100 ? 1.02681   10.83477  7.44413   1.000 25.05114  ? 99  LEU B CD1  1 
ATOM   2208 C CD2  . LEU B 1 100 ? -0.27911  8.80378   8.06834   1.000 23.50916  ? 99  LEU B CD2  1 
ATOM   2209 N N    . TYR B 1 101 ? 2.32000   7.01083   3.55680   1.000 33.89261  ? 100 TYR B N    1 
ATOM   2210 C CA   . TYR B 1 101 ? 2.22473   6.41687   2.19680   1.000 35.58901  ? 100 TYR B CA   1 
ATOM   2211 C C    . TYR B 1 101 ? 2.40472   4.89486   2.29874   1.000 33.34505  ? 100 TYR B C    1 
ATOM   2212 O O    . TYR B 1 101 ? 1.66059   4.15889   1.66086   1.000 33.22428  ? 100 TYR B O    1 
ATOM   2213 C CB   . TYR B 1 101 ? 3.21056   7.09587   1.25263   1.000 29.35427  ? 100 TYR B CB   1 
ATOM   2214 C CG   . TYR B 1 101 ? 2.76949   8.45189   0.77375   1.000 42.61575  ? 100 TYR B CG   1 
ATOM   2215 C CD1  . TYR B 1 101 ? 1.42945   8.73492   0.56601   1.000 53.73289  ? 100 TYR B CD1  1 
ATOM   2216 C CD2  . TYR B 1 101 ? 3.68546   9.46088   0.53359   1.000 62.14983  ? 100 TYR B CD2  1 
ATOM   2217 C CE1  . TYR B 1 101 ? 1.01239   9.97793   0.12312   1.000 46.58571  ? 100 TYR B CE1  1 
ATOM   2218 C CE2  . TYR B 1 101 ? 3.28640   10.70790  0.08870   1.000 68.33491  ? 100 TYR B CE2  1 
ATOM   2219 C CZ   . TYR B 1 101 ? 1.94436   10.96992  -0.11304  1.000 66.50852  ? 100 TYR B CZ   1 
ATOM   2220 O OH   . TYR B 1 101 ? 1.54430   12.19894  -0.54794  1.000 55.86966  ? 100 TYR B OH   1 
ATOM   2221 N N    . GLU B 1 102 ? 3.31788   4.45683   3.15555   1.000 31.87031  ? 101 GLU B N    1 
ATOM   2222 C CA   . GLU B 1 102 ? 3.55489   3.00282   3.34147   1.000 39.30512  ? 101 GLU B CA   1 
ATOM   2223 C C    . GLU B 1 102 ? 2.31600   2.34082   3.96270   1.000 38.56633  ? 101 GLU B C    1 
ATOM   2224 O O    . GLU B 1 102 ? 1.95690   1.24784   3.52474   1.000 37.28860  ? 101 GLU B O    1 
ATOM   2225 C CB   . GLU B 1 102 ? 4.81405   2.76878   4.17823   1.000 40.70417  ? 101 GLU B CB   1 
ATOM   2226 C CG   . GLU B 1 102 ? 6.09692   3.18577   3.48699   1.000 41.00014  ? 101 GLU B CG   1 
ATOM   2227 C CD   . GLU B 1 102 ? 7.29310   3.32673   4.41376   1.000 57.12316  ? 101 GLU B CD   1 
ATOM   2228 O OE1  . GLU B 1 102 ? 7.09734   3.29271   5.64180   1.000 64.20442  ? 101 GLU B OE1  1 
ATOM   2229 O OE2  . GLU B 1 102 ? 8.41801   3.47173   3.90655   1.000 68.47877  ? 101 GLU B OE2  1 
ATOM   2230 N N    . GLU B 1 103 ? 1.69720   2.99781   4.93483   1.000 31.34577  ? 102 GLU B N    1 
ATOM   2231 C CA   . GLU B 1 103 ? 0.48031   2.44182   5.57405   1.000 35.02392  ? 102 GLU B CA   1 
ATOM   2232 C C    . GLU B 1 103 ? -0.64189  2.32986   4.52726   1.000 34.63915  ? 102 GLU B C    1 
ATOM   2233 O O    . GLU B 1 103 ? -1.37191  1.34187   4.54638   1.000 31.17417  ? 102 GLU B O    1 
ATOM   2234 C CB   . GLU B 1 103 ? 0.06755   3.30580   6.76415   1.000 28.84481  ? 102 GLU B CB   1 
ATOM   2235 C CG   . GLU B 1 103 ? 1.01778   3.26976   7.94496   1.000 35.26872  ? 102 GLU B CG   1 
ATOM   2236 C CD   . GLU B 1 103 ? 0.54602   4.10274   9.12507   1.000 37.89691  ? 102 GLU B CD   1 
ATOM   2237 O OE1  . GLU B 1 103 ? -0.64297  4.45276   9.15831   1.000 35.97659  ? 102 GLU B OE1  1 
ATOM   2238 O OE2  . GLU B 1 103 ? 1.36419   4.40470   10.00092  1.000 34.61497  ? 102 GLU B OE2  1 
ATOM   2239 N N    . ALA B 1 104 ? -0.75405  3.31488   3.64431   1.000 30.54009  ? 103 ALA B N    1 
ATOM   2240 C CA   . ALA B 1 104 ? -1.81624  3.30392   2.61951   1.000 33.01283  ? 103 ALA B CA   1 
ATOM   2241 C C    . ALA B 1 104 ? -1.60745  2.14994   1.62844   1.000 35.71394  ? 103 ALA B C    1 
ATOM   2242 O O    . ALA B 1 104 ? -2.58453  1.50897   1.25461   1.000 35.30138  ? 103 ALA B O    1 
ATOM   2243 C CB   . ALA B 1 104 ? -1.84935  4.62994   1.92154   1.000 42.07126  ? 103 ALA B CB   1 
ATOM   2244 N N    . LYS B 1 105 ? -0.36653  1.92693   1.22220   1.000 30.72710  ? 104 LYS B N    1 
ATOM   2245 C CA   . LYS B 1 105 ? -0.06374  0.85195   0.25112   1.000 47.61512  ? 104 LYS B CA   1 
ATOM   2246 C C    . LYS B 1 105 ? -0.40764  -0.49306  0.89315   1.000 40.00466  ? 104 LYS B C    1 
ATOM   2247 O O    . LYS B 1 105 ? -1.00278  -1.32504  0.21325   1.000 48.01109  ? 104 LYS B O    1 
ATOM   2248 C CB   . LYS B 1 105 ? 1.40519   0.94493   -0.15616  1.000 40.44428  ? 104 LYS B CB   1 
ATOM   2249 C CG   . LYS B 1 105 ? 1.67890   0.85296   -1.64822  1.000 66.19022  ? 104 LYS B CG   1 
ATOM   2250 C CD   . LYS B 1 105 ? 2.11979   -0.52204  -2.08933  1.000 73.98758  ? 104 LYS B CD   1 
ATOM   2251 C CE   . LYS B 1 105 ? 2.09750   -0.69700  -3.59333  1.000 80.89524  ? 104 LYS B CE   1 
ATOM   2252 N NZ   . LYS B 1 105 ? 0.71340   -0.79497  -4.11407  1.000 74.97970  ? 104 LYS B NZ   1 
ATOM   2253 N N    . ARG B 1 106 ? -0.07439  -0.66310  2.16809   1.000 36.02197  ? 105 ARG B N    1 
ATOM   2254 C CA   . ARG B 1 106 ? -0.42328  -1.90511  2.89312   1.000 43.56325  ? 105 ARG B CA   1 
ATOM   2255 C C    . ARG B 1 106 ? -1.94126  -2.04908  2.96741   1.000 41.62360  ? 105 ARG B C    1 
ATOM   2256 O O    . ARG B 1 106 ? -2.42733  -3.15007  2.73348   1.000 50.00323  ? 105 ARG B O    1 
ATOM   2257 C CB   . ARG B 1 106 ? 0.20899   -1.88615  4.28500   1.000 33.48556  ? 105 ARG B CB   1 
ATOM   2258 C CG   . ARG B 1 106 ? 1.72699   -1.79017  4.28172   1.000 55.34000  ? 105 ARG B CG   1 
ATOM   2259 C CD   . ARG B 1 106 ? 2.33922   -2.39321  5.53258   1.000 54.00480  ? 105 ARG B CD   1 
ATOM   2260 N NE   . ARG B 1 106 ? 1.99147   -1.67923  6.75167   1.000 56.74253  ? 105 ARG B NE   1 
ATOM   2261 C CZ   . ARG B 1 106 ? 2.73259   -0.72526  7.30455   1.000 54.75658  ? 105 ARG B CZ   1 
ATOM   2262 N NH1  . ARG B 1 106 ? 3.87049   -0.36126  6.74434   1.000 48.58671  ? 105 ARG B NH1  1 
ATOM   2263 N NH2  . ARG B 1 106 ? 2.32781   -0.13728  8.41464   1.000 59.21491  ? 105 ARG B NH2  1 
ATOM   2264 N N    . LEU B 1 107 ? -2.65319  -0.96608  3.26257   1.000 38.48759  ? 106 LEU B N    1 
ATOM   2265 C CA   . LEU B 1 107 ? -4.12516  -1.02506  3.40785   1.000 40.81000  ? 106 LEU B CA   1 
ATOM   2266 C C    . LEU B 1 107 ? -4.74843  -1.40302  2.06596   1.000 31.71062  ? 106 LEU B C    1 
ATOM   2267 O O    . LEU B 1 107 ? -5.65644  -2.22400  2.04912   1.000 34.08033  ? 106 LEU B O    1 
ATOM   2268 C CB   . LEU B 1 107 ? -4.61705  0.34094   3.89498   1.000 42.19236  ? 106 LEU B CB   1 
ATOM   2269 C CG   . LEU B 1 107 ? -5.90489  0.33194   4.71122   1.000 54.20290  ? 106 LEU B CG   1 
ATOM   2270 C CD1  . LEU B 1 107 ? -5.96170  1.54292   5.62626   1.000 48.67116  ? 106 LEU B CD1  1 
ATOM   2271 C CD2  . LEU B 1 107 ? -7.12007  0.29298   3.79746   1.000 58.83935  ? 106 LEU B CD2  1 
ATOM   2272 N N    . MET B 1 108 ? -4.23562  -0.82500  0.98988   1.000 36.31968  ? 107 MET B N    1 
ATOM   2273 C CA   . MET B 1 108 ? -4.76489  -1.09596  -0.36203  1.000 48.03549  ? 107 MET B CA   1 
ATOM   2274 C C    . MET B 1 108 ? -4.51198  -2.55696  -0.73111  1.000 36.53822  ? 107 MET B C    1 
ATOM   2275 O O    . MET B 1 108 ? -5.41909  -3.17893  -1.27395  1.000 45.43114  ? 107 MET B O    1 
ATOM   2276 C CB   . MET B 1 108 ? -4.11407  -0.16795  -1.38513  1.000 41.38906  ? 107 MET B CB   1 
ATOM   2277 C CG   . MET B 1 108 ? -4.68503  1.24006   -1.32499  1.000 62.21829  ? 107 MET B CG   1 
ATOM   2278 S SD   . MET B 1 108 ? -4.85233  2.04410   -2.93194  1.000 65.32384  ? 107 MET B SD   1 
ATOM   2279 C CE   . MET B 1 108 ? -3.24534  2.82507   -3.06423  1.000 51.73250  ? 107 MET B CE   1 
ATOM   2280 N N    . GLU B 1 109 ? -3.31993  -3.06298  -0.44235  1.000 35.95871  ? 108 GLU B N    1 
ATOM   2281 C CA   . GLU B 1 109 ? -3.01701  -4.49298  -0.69344  1.000 46.21998  ? 108 GLU B CA   1 
ATOM   2282 C C    . GLU B 1 109 ? -4.06788  -5.34698  0.01274   1.000 41.46217  ? 108 GLU B C    1 
ATOM   2283 O O    . GLU B 1 109 ? -4.63402  -6.23096  -0.62517  1.000 44.96227  ? 108 GLU B O    1 
ATOM   2284 C CB   . GLU B 1 109 ? -1.61392  -4.82702  -0.19871  1.000 40.88543  ? 108 GLU B CB   1 
ATOM   2285 C CG   . GLU B 1 109 ? -0.51409  -4.38801  -1.14391  1.000 70.94591  ? 108 GLU B CG   1 
ATOM   2286 C CD   . GLU B 1 109 ? 0.85903   -4.22605  -0.51117  1.000 79.21571  ? 108 GLU B CD   1 
ATOM   2287 O OE1  . GLU B 1 109 ? 1.03125   -4.64008  0.65078   1.000 65.34408  ? 108 GLU B OE1  1 
ATOM   2288 O OE2  . GLU B 1 109 ? 1.75091   -3.68405  -1.18633  1.000 86.72199  ? 108 GLU B OE2  1 
ATOM   2289 N N    . LYS B 1 110 ? -4.33264  -5.05301  1.28080   1.000 42.38342  ? 109 LYS B N    1 
ATOM   2290 C CA   . LYS B 1 110 ? -5.32850  -5.81901  2.06398   1.000 37.15010  ? 109 LYS B CA   1 
ATOM   2291 C C    . LYS B 1 110 ? -6.70163  -5.73497  1.39524   1.000 45.24226  ? 109 LYS B C    1 
ATOM   2292 O O    . LYS B 1 110 ? -7.35467  -6.76596  1.27134   1.000 39.44948  ? 109 LYS B O    1 
ATOM   2293 C CB   . LYS B 1 110 ? -5.33922  -5.29304  3.49899   1.000 44.07223  ? 109 LYS B CB   1 
ATOM   2294 N N    . ALA B 1 111 ? -7.11169  -4.54295  0.98135   1.000 37.01110  ? 110 ALA B N    1 
ATOM   2295 C CA   . ALA B 1 111 ? -8.44280  -4.37392  0.36660   1.000 49.38090  ? 110 ALA B CA   1 
ATOM   2296 C C    . ALA B 1 111 ? -8.53506  -5.17689  -0.93340  1.000 40.77639  ? 110 ALA B C    1 
ATOM   2297 O O    . ALA B 1 111 ? -9.58212  -5.77186  -1.17521  1.000 48.25364  ? 110 ALA B O    1 
ATOM   2298 C CB   . ALA B 1 111 ? -8.71183  -2.92091  0.10269   1.000 46.44032  ? 110 ALA B CB   1 
ATOM   2299 N N    . LYS B 1 112 ? -7.47721  -5.16489  -1.72860  1.000 40.06033  ? 111 LYS B N    1 
ATOM   2300 C CA   . LYS B 1 112 ? -7.46347  -5.89386  -3.02262  1.000 47.64308  ? 111 LYS B CA   1 
ATOM   2301 C C    . LYS B 1 112 ? -7.60645  -7.38786  -2.74662  1.000 40.52454  ? 111 LYS B C    1 
ATOM   2302 O O    . LYS B 1 112 ? -8.41358  -8.03183  -3.40448  1.000 44.49659  ? 111 LYS B O    1 
ATOM   2303 C CB   . LYS B 1 112 ? -6.15961  -5.59386  -3.76486  1.000 31.40918  ? 111 LYS B CB   1 
ATOM   2304 C CG   . LYS B 1 112 ? -6.02969  -4.17885  -4.30385  1.000 60.45478  ? 111 LYS B CG   1 
ATOM   2305 C CD   . LYS B 1 112 ? -4.62366  -3.63188  -4.19911  1.000 74.59700  ? 111 LYS B CD   1 
ATOM   2306 C CE   . LYS B 1 112 ? -3.73889  -4.03687  -5.35629  1.000 73.79642  ? 111 LYS B CE   1 
ATOM   2307 N NZ   . LYS B 1 112 ? -2.31282  -4.10890  -4.95956  1.000 69.20166  ? 111 LYS B NZ   1 
ATOM   2308 N N    . GLU B 1 113 ? -6.83927  -7.88789  -1.78978  1.000 40.75013  ? 112 GLU B N    1 
ATOM   2309 C CA   . GLU B 1 113 ? -6.90423  -9.31890  -1.42980  1.000 49.67189  ? 112 GLU B CA   1 
ATOM   2310 C C    . GLU B 1 113 ? -8.32014  -9.66889  -0.95954  1.000 56.68276  ? 112 GLU B C    1 
ATOM   2311 O O    . GLU B 1 113 ? -8.86025  -10.67087 -1.44346  1.000 53.92111  ? 112 GLU B O    1 
ATOM   2312 C CB   . GLU B 1 113 ? -5.86503  -9.61594  -0.35701  1.000 42.16317  ? 112 GLU B CB   1 
ATOM   2313 C CG   . GLU B 1 113 ? -4.44510  -9.30796  -0.78827  1.000 58.83814  ? 112 GLU B CG   1 
ATOM   2314 C CD   . GLU B 1 113 ? -3.40390  -9.49700  0.30152   1.000 64.90133  ? 112 GLU B CD   1 
ATOM   2315 O OE1  . GLU B 1 113 ? -3.79568  -9.69702  1.46659   1.000 63.23554  ? 112 GLU B OE1  1 
ATOM   2316 O OE2  . GLU B 1 113 ? -2.20396  -9.44801  -0.01970  1.000 83.55502  ? 112 GLU B OE2  1 
ATOM   2317 N N    . LEU B 1 114 ? -8.89096  -8.87590  -0.05841  1.000 37.42575  ? 113 LEU B N    1 
ATOM   2318 C CA   . LEU B 1 114 ? -10.22686 -9.21089  0.48384   1.000 57.78458  ? 113 LEU B CA   1 
ATOM   2319 C C    . LEU B 1 114 ? -11.24108 -9.22385  -0.66197  1.000 46.34327  ? 113 LEU B C    1 
ATOM   2320 O O    . LEU B 1 114 ? -12.11209 -10.08583 -0.66082  1.000 42.33085  ? 113 LEU B O    1 
ATOM   2321 C CB   . LEU B 1 114 ? -10.62064 -8.19191  1.55193   1.000 51.09291  ? 113 LEU B CB   1 
ATOM   2322 C CG   . LEU B 1 114 ? -12.02953 -8.37190  2.10520   1.000 52.54908  ? 113 LEU B CG   1 
ATOM   2323 C CD1  . LEU B 1 114 ? -12.05535 -9.48492  3.14218   1.000 58.20133  ? 113 LEU B CD1  1 
ATOM   2324 C CD2  . LEU B 1 114 ? -12.55840 -7.07390  2.69433   1.000 66.31428  ? 113 LEU B CD2  1 
ATOM   2325 N N    . THR B 1 115 ? -11.09224 -8.29783  -1.60098  1.000 44.45230  ? 114 THR B N    1 
ATOM   2326 C CA   . THR B 1 115 ? -12.04346 -8.18479  -2.73379  1.000 51.68268  ? 114 THR B CA   1 
ATOM   2327 C C    . THR B 1 115 ? -11.90065 -9.41177  -3.64285  1.000 50.06473  ? 114 THR B C    1 
ATOM   2328 O O    . THR B 1 115 ? -12.92574 -9.94474  -4.07666  1.000 44.93877  ? 114 THR B O    1 
ATOM   2329 C CB   . THR B 1 115 ? -11.88057 -6.82578  -3.42579  1.000 55.86675  ? 114 THR B CB   1 
ATOM   2330 O OG1  . THR B 1 115 ? -12.10936 -5.81779  -2.44273  1.000 49.35231  ? 114 THR B OG1  1 
ATOM   2331 C CG2  . THR B 1 115 ? -12.82579 -6.63173  -4.58961  1.000 56.76220  ? 114 THR B CG2  1 
ATOM   2332 N N    . LYS B 1 116 ? -10.67370 -9.86679  -3.85909  1.000 37.35287  ? 115 LYS B N    1 
ATOM   2333 C CA   . LYS B 1 116 ? -10.45388 -11.06377 -4.69416  1.000 50.80605  ? 115 LYS B CA   1 
ATOM   2334 C C    . LYS B 1 116 ? -11.15177 -12.25177 -4.03805  1.000 47.63837  ? 115 LYS B C    1 
ATOM   2335 O O    . LYS B 1 116 ? -11.87492 -12.96775 -4.74993  1.000 57.29323  ? 115 LYS B O    1 
ATOM   2336 C CB   . LYS B 1 116 ? -8.96191  -11.35079 -4.84945  1.000 48.75067  ? 115 LYS B CB   1 
ATOM   2337 C CG   . LYS B 1 116 ? -8.61405  -12.69478 -5.46855  1.000 62.52635  ? 115 LYS B CG   1 
ATOM   2338 C CD   . LYS B 1 116 ? -7.33721  -12.65379 -6.27779  1.000 62.62579  ? 115 LYS B CD   1 
ATOM   2339 C CE   . LYS B 1 116 ? -6.71727  -14.02079 -6.48394  1.000 77.14995  ? 115 LYS B CE   1 
ATOM   2340 N NZ   . LYS B 1 116 ? -7.33250  -14.73376 -7.62684  1.000 62.53204  ? 115 LYS B NZ   1 
ATOM   2341 N N    . ARG B 1 117 ? -10.96053 -12.42081 -2.73610  1.000 41.52421  ? 116 ARG B N    1 
ATOM   2342 C CA   . ARG B 1 117 ? -11.54441 -13.57181 -2.01401  1.000 37.19740  ? 116 ARG B CA   1 
ATOM   2343 C C    . ARG B 1 117 ? -13.06942 -13.53679 -2.09972  1.000 43.84574  ? 116 ARG B C    1 
ATOM   2344 O O    . ARG B 1 117 ? -13.65349 -14.59777 -2.34563  1.000 45.37216  ? 116 ARG B O    1 
ATOM   2345 C CB   . ARG B 1 117 ? -11.05413 -13.53985 -0.57110  1.000 42.76394  ? 116 ARG B CB   1 
ATOM   2346 C CG   . ARG B 1 117 ? -9.53911  -13.55588 -0.44139  1.000 57.24346  ? 116 ARG B CG   1 
ATOM   2347 C CD   . ARG B 1 117 ? -9.08883  -13.74492 0.99252   1.000 47.18052  ? 116 ARG B CD   1 
ATOM   2348 N NE   . ARG B 1 117 ? -10.22066 -13.79492 1.90573   1.000 59.22401  ? 116 ARG B NE   1 
ATOM   2349 C CZ   . ARG B 1 117 ? -10.29643 -13.12995 3.04776   1.000 71.18685  ? 116 ARG B CZ   1 
ATOM   2350 N NH1  . ARG B 1 117 ? -9.29635  -12.35397 3.42459   1.000 72.48890  ? 116 ARG B NH1  1 
ATOM   2351 N NH2  . ARG B 1 117 ? -11.37229 -13.23595 3.80497   1.000 59.43098  ? 116 ARG B NH2  1 
ATOM   2352 N N    . ILE B 1 118 ? -13.67838 -12.36378 -1.94957  1.000 46.89518  ? 117 ILE B N    1 
ATOM   2353 C CA   . ILE B 1 118 ? -15.16437 -12.24275 -1.91529  1.000 44.25548  ? 117 ILE B CA   1 
ATOM   2354 C C    . ILE B 1 118 ? -15.74964 -12.55371 -3.29118  1.000 41.62334  ? 117 ILE B C    1 
ATOM   2355 O O    . ILE B 1 118 ? -16.87366 -13.04469 -3.35698  1.000 45.61146  ? 117 ILE B O    1 
ATOM   2356 C CB   . ILE B 1 118 ? -15.57425 -10.84176 -1.41218  1.000 43.15224  ? 117 ILE B CB   1 
ATOM   2357 C CG1  . ILE B 1 118 ? -16.98613 -10.84375 -0.81991  1.000 46.88590  ? 117 ILE B CG1  1 
ATOM   2358 C CG2  . ILE B 1 118 ? -15.43244 -9.80074  -2.51118  1.000 46.68207  ? 117 ILE B CG2  1 
ATOM   2359 C CD1  . ILE B 1 118 ? -17.22796 -11.93577 0.18912   1.000 42.43357  ? 117 ILE B CD1  1 
ATOM   2360 N N    . LYS B 1 119 ? -15.00583 -12.25670 -4.34632  1.000 43.39553  ? 118 LYS B N    1 
ATOM   2361 C CA   . LYS B 1 119 ? -15.51410 -12.47166 -5.71922  1.000 46.88776  ? 118 LYS B CA   1 
ATOM   2362 C C    . LYS B 1 119 ? -15.71418 -13.96865 -5.98922  1.000 48.16495  ? 118 LYS B C    1 
ATOM   2363 O O    . LYS B 1 119 ? -16.49735 -14.28862 -6.88508  1.000 38.79373  ? 118 LYS B O    1 
ATOM   2364 C CB   . LYS B 1 119 ? -14.52028 -11.86066 -6.71140  1.000 45.23302  ? 118 LYS B CB   1 
ATOM   2365 C CG   . LYS B 1 119 ? -14.51927 -10.34166 -6.78837  1.000 54.16667  ? 118 LYS B CG   1 
ATOM   2366 C CD   . LYS B 1 119 ? -13.38442 -9.79766  -7.62257  1.000 56.89379  ? 118 LYS B CD   1 
ATOM   2367 C CE   . LYS B 1 119 ? -13.55771 -10.07462 -9.10055  1.000 63.62129  ? 118 LYS B CE   1 
ATOM   2368 N NZ   . LYS B 1 119 ? -12.28885 -9.91462  -9.84978  1.000 59.82187  ? 118 LYS B NZ   1 
ATOM   2369 N N    . LYS B 1 120 ? -15.07904 -14.83668 -5.20236  1.000 46.29055  ? 119 LYS B N    1 
ATOM   2370 C CA   . LYS B 1 120 ? -15.10411 -16.30068 -5.46539  1.000 49.31955  ? 119 LYS B CA   1 
ATOM   2371 C C    . LYS B 1 120 ? -16.27299 -16.98367 -4.74718  1.000 59.35144  ? 119 LYS B C    1 
ATOM   2372 O O    . LYS B 1 120 ? -16.39403 -18.20667 -4.87519  1.000 55.45136  ? 119 LYS B O    1 
ATOM   2373 C CB   . LYS B 1 120 ? -13.75304 -16.87571 -5.03666  1.000 40.93481  ? 119 LYS B CB   1 
ATOM   2374 C CG   . LYS B 1 120 ? -12.56019 -16.38471 -5.84488  1.000 42.95813  ? 119 LYS B CG   1 
ATOM   2375 C CD   . LYS B 1 120 ? -11.25311 -16.97374 -5.39214  1.000 54.29468  ? 119 LYS B CD   1 
ATOM   2376 C CE   . LYS B 1 120 ? -10.06725 -16.44274 -6.17136  1.000 52.14605  ? 119 LYS B CE   1 
ATOM   2377 N NZ   . LYS B 1 120 ? -10.14953 -16.80471 -7.60335  1.000 69.50304  ? 119 LYS B NZ   1 
ATOM   2378 N N    . ILE B 1 121 ? -17.09384 -16.21968 -4.03601  1.000 47.69153  ? 120 ILE B N    1 
ATOM   2379 C CA   . ILE B 1 121 ? -18.23170 -16.79867 -3.26980  1.000 50.84813  ? 120 ILE B CA   1 
ATOM   2380 C C    . ILE B 1 121 ? -19.54581 -16.27664 -3.85654  1.000 60.59996  ? 120 ILE B C    1 
ATOM   2381 O O    . ILE B 1 121 ? -19.52890 -15.19963 -4.45652  1.000 56.07967  ? 120 ILE B O    1 
ATOM   2382 C CB   . ILE B 1 121 ? -18.09541 -16.43771 -1.78082  1.000 62.56341  ? 120 ILE B CB   1 
ATOM   2383 C CG1  . ILE B 1 121 ? -16.75931 -16.90774 -1.20809  1.000 58.19436  ? 120 ILE B CG1  1 
ATOM   2384 C CG2  . ILE B 1 121 ? -19.27327 -16.97571 -0.98461  1.000 73.64369  ? 120 ILE B CG2  1 
ATOM   2385 C CD1  . ILE B 1 121 ? -16.72227 -18.37275 -0.86913  1.000 61.09315  ? 120 ILE B CD1  1 
ATOM   2386 N N    . ASP B 1 122 ? -20.62880 -17.05662 -3.78635  1.000 53.02191  ? 121 ASP B N    1 
ATOM   2387 C CA   . ASP B 1 122 ? -21.95589 -16.61059 -4.28608  1.000 63.43812  ? 121 ASP B CA   1 
ATOM   2388 C C    . ASP B 1 122 ? -22.71167 -15.88960 -3.16492  1.000 81.23408  ? 121 ASP B C    1 
ATOM   2389 O O    . ASP B 1 122 ? -22.73846 -16.42663 -2.05293  1.000 79.29883  ? 121 ASP B O    1 
ATOM   2390 C CB   . ASP B 1 122 ? -22.73503 -17.77756 -4.88896  1.000 71.81163  ? 121 ASP B CB   1 
ATOM   2391 C CG   . ASP B 1 122 ? -22.63932 -17.83753 -6.40498  1.000 79.66311  ? 121 ASP B CG   1 
ATOM   2392 O OD1  . ASP B 1 122 ? -21.93241 -16.99053 -6.97810  1.000 89.80177  ? 121 ASP B OD1  1 
ATOM   2393 O OD2  . ASP B 1 122 ? -23.27445 -18.73051 -6.99588  1.000 88.37828  ? 121 ASP B OD2  1 
ATOM   2394 N N    . THR B 1 123 ? -23.30570 -14.72359 -3.44978  1.000 91.76638  ? 122 THR B N    1 
ATOM   2395 C CA   . THR B 1 123 ? -23.95748 -13.89760 -2.38164  1.000 85.28763  ? 122 THR B CA   1 
ATOM   2396 C C    . THR B 1 123 ? -24.80733 -14.79461 -1.48950  1.000 80.99989  ? 122 THR B C    1 
ATOM   2397 O O    . THR B 1 123 ? -25.84243 -15.29958 -1.96331  1.000 77.92038  ? 122 THR B O    1 
ATOM   2398 C CB   . THR B 1 123 ? -24.67757 -12.64858 -2.91947  1.000 85.80195  ? 122 THR B CB   1 
ATOM   2399 N N    . THR B 1 124 ? -24.39109 -14.93364 -0.23358  1.000 90.47435  ? 123 THR B N    1 
ATOM   2400 C CA   . THR B 1 124 ? -25.06994 -15.90765 0.65353   1.000 90.17912  ? 123 THR B CA   1 
ATOM   2401 C C    . THR B 1 124 ? -25.67069 -15.25867 1.89466   1.000 89.14857  ? 123 THR B C    1 
ATOM   2402 O O    . THR B 1 124 ? -26.44070 -14.28665 1.75183   1.000 89.88523  ? 123 THR B O    1 
ATOM   2403 C CB   . THR B 1 124 ? -24.10287 -17.00668 1.10232   1.000 70.27459  ? 123 THR B CB   1 
ATOM   2404 N N    . ASP B 1 125 ? -25.34147 -15.80070 3.06358   1.000 86.24514  ? 124 ASP B N    1 
ATOM   2405 C CA   . ASP B 1 125 ? -25.98923 -15.34372 4.31472   1.000 81.89116  ? 124 ASP B CA   1 
ATOM   2406 C C    . ASP B 1 125 ? -25.69815 -13.87573 4.59169   1.000 86.82238  ? 124 ASP B C    1 
ATOM   2407 O O    . ASP B 1 125 ? -24.57019 -13.43074 4.31149   1.000 98.30272  ? 124 ASP B O    1 
ATOM   2408 C CB   . ASP B 1 125 ? -25.59102 -16.23775 5.48762   1.000 87.98612  ? 124 ASP B CB   1 
ATOM   2409 C CG   . ASP B 1 125 ? -24.09898 -16.42078 5.67333   1.000 94.98382  ? 124 ASP B CG   1 
ATOM   2410 O OD1  . ASP B 1 125 ? -23.44917 -16.94477 4.74719   1.000 91.56356  ? 124 ASP B OD1  1 
ATOM   2411 O OD2  . ASP B 1 125 ? -23.59977 -16.06281 6.75424   1.000 100.96724 ? 124 ASP B OD2  1 
ATOM   2412 N N    . GLU B 1 126 ? -26.68803 -13.16472 5.13190   1.000 92.84478  ? 125 GLU B N    1 
ATOM   2413 C CA   . GLU B 1 126 ? -26.47693 -11.76074 5.54789   1.000 89.73023  ? 125 GLU B CA   1 
ATOM   2414 C C    . GLU B 1 126 ? -25.15379 -11.67078 6.29964   1.000 97.64872  ? 125 GLU B C    1 
ATOM   2415 O O    . GLU B 1 126 ? -24.29386 -10.90478 5.84849   1.000 92.46929  ? 125 GLU B O    1 
ATOM   2416 C CB   . GLU B 1 126 ? -27.58774 -11.34874 6.50211   1.000 72.83086  ? 125 GLU B CB   1 
ATOM   2417 C CG   . GLU B 1 126 ? -27.47562 -9.91775  6.99112   1.000 86.42281  ? 125 GLU B CG   1 
ATOM   2418 C CD   . GLU B 1 126 ? -28.56970 -8.99672  6.49135   1.000 99.30216  ? 125 GLU B CD   1 
ATOM   2419 O OE1  . GLU B 1 126 ? -29.75267 -9.32971  6.69057   1.000 89.59490  ? 125 GLU B OE1  1 
ATOM   2420 O OE2  . GLU B 1 126 ? -28.23480 -7.95072  5.89931   1.000 98.12058  ? 125 GLU B OE2  1 
ATOM   2421 N N    . LYS B 1 127 ? -24.98160 -12.48080 7.34959   1.000 89.25400  ? 126 LYS B N    1 
ATOM   2422 C CA   . LYS B 1 127 ? -23.76943 -12.38584 8.20536   1.000 89.46450  ? 126 LYS B CA   1 
ATOM   2423 C C    . LYS B 1 127 ? -22.46059 -12.43184 7.40211   1.000 84.79391  ? 126 LYS B C    1 
ATOM   2424 O O    . LYS B 1 127 ? -21.59051 -11.63487 7.73096   1.000 85.92360  ? 126 LYS B O    1 
ATOM   2425 C CB   . LYS B 1 127 ? -23.80325 -13.48886 9.26734   1.000 67.18439  ? 126 LYS B CB   1 
ATOM   2426 C CG   . LYS B 1 127 ? -23.03800 -13.18891 10.54720  1.000 85.45226  ? 126 LYS B CG   1 
ATOM   2427 C CD   . LYS B 1 127 ? -22.97484 -14.37693 11.47916  1.000 95.24295  ? 126 LYS B CD   1 
ATOM   2428 C CE   . LYS B 1 127 ? -22.43657 -14.01997 12.84807  1.000 92.09451  ? 126 LYS B CE   1 
ATOM   2429 N NZ   . LYS B 1 127 ? -20.96757 -13.82299 12.82579  1.000 98.08412  ? 126 LYS B NZ   1 
ATOM   2430 N N    . THR B 1 128 ? -22.30879 -13.31982 6.42306   1.000 67.50038  ? 127 THR B N    1 
ATOM   2431 C CA   . THR B 1 128 ? -20.99292 -13.45883 5.73480   1.000 77.81826  ? 127 THR B CA   1 
ATOM   2432 C C    . THR B 1 128 ? -20.67005 -12.18382 4.95077   1.000 80.76558  ? 127 THR B C    1 
ATOM   2433 O O    . THR B 1 128 ? -19.56801 -11.64884 5.13157   1.000 74.31913  ? 127 THR B O    1 
ATOM   2434 C CB   . THR B 1 128 ? -20.94311 -14.73081 4.88876   1.000 73.46685  ? 127 THR B CB   1 
ATOM   2435 O OG1  . THR B 1 128 ? -20.64195 -15.79384 5.79268   1.000 80.64384  ? 127 THR B OG1  1 
ATOM   2436 C CG2  . THR B 1 128 ? -19.91632 -14.70380 3.77957   1.000 78.44678  ? 127 THR B CG2  1 
ATOM   2437 N N    . LEU B 1 129 ? -21.59720 -11.71678 4.11896   1.000 77.15754  ? 128 LEU B N    1 
ATOM   2438 C CA   . LEU B 1 129 ? -21.38432 -10.43477 3.41594   1.000 79.36988  ? 128 LEU B CA   1 
ATOM   2439 C C    . LEU B 1 129 ? -21.16610 -9.34580  4.45993   1.000 69.09425  ? 128 LEU B C    1 
ATOM   2440 O O    . LEU B 1 129 ? -20.35313 -8.46881  4.20779   1.000 76.28310  ? 128 LEU B O    1 
ATOM   2441 C CB   . LEU B 1 129 ? -22.61747 -10.12873 2.56819   1.000 81.21489  ? 128 LEU B CB   1 
ATOM   2442 C CG   . LEU B 1 129 ? -22.95170 -11.14770 1.48023   1.000 80.68378  ? 128 LEU B CG   1 
ATOM   2443 C CD1  . LEU B 1 129 ? -24.44171 -11.43768 1.46451   1.000 84.74248  ? 128 LEU B CD1  1 
ATOM   2444 C CD2  . LEU B 1 129 ? -22.50395 -10.64068 0.12415   1.000 67.80430  ? 128 LEU B CD2  1 
ATOM   2445 N N    . ARG B 1 130 ? -21.84788 -9.42481  5.59806   1.000 65.73024  ? 129 ARG B N    1 
ATOM   2446 C CA   . ARG B 1 130 ? -21.75367 -8.34484  6.60706   1.000 70.13094  ? 129 ARG B CA   1 
ATOM   2447 C C    . ARG B 1 130 ? -20.40154 -8.39488  7.31680   1.000 66.91396  ? 129 ARG B C    1 
ATOM   2448 O O    . ARG B 1 130 ? -19.93544 -7.32989  7.72774   1.000 72.03826  ? 129 ARG B O    1 
ATOM   2449 C CB   . ARG B 1 130 ? -22.91648 -8.43484  7.59928   1.000 77.10685  ? 129 ARG B CB   1 
ATOM   2450 C CG   . ARG B 1 130 ? -24.22157 -7.84281  7.09255   1.000 70.50655  ? 129 ARG B CG   1 
ATOM   2451 C CD   . ARG B 1 130 ? -24.12060 -6.35880  6.82856   1.000 91.28855  ? 129 ARG B CD   1 
ATOM   2452 N NE   . ARG B 1 130 ? -24.12535 -5.55983  8.04358   1.000 82.55432  ? 129 ARG B NE   1 
ATOM   2453 C CZ   . ARG B 1 130 ? -24.45532 -4.27583  8.09367   1.000 86.82341  ? 129 ARG B CZ   1 
ATOM   2454 N NH1  . ARG B 1 130 ? -24.81552 -3.64080  6.99375   1.000 95.01391  ? 129 ARG B NH1  1 
ATOM   2455 N NH2  . ARG B 1 130 ? -24.42909 -3.63285  9.24768   1.000 89.59823  ? 129 ARG B NH2  1 
ATOM   2456 N N    . GLU B 1 131 ? -19.80153 -9.57489  7.46666   1.000 70.12481  ? 130 GLU B N    1 
ATOM   2457 C CA   . GLU B 1 131 ? -18.44841 -9.64193  8.06240   1.000 75.96778  ? 130 GLU B CA   1 
ATOM   2458 C C    . GLU B 1 131 ? -17.47159 -9.00692  7.07923   1.000 59.99001  ? 130 GLU B C    1 
ATOM   2459 O O    . GLU B 1 131 ? -16.54849 -8.33594  7.53207   1.000 67.25295  ? 130 GLU B O    1 
ATOM   2460 C CB   . GLU B 1 131 ? -17.99340 -11.08294 8.25428   1.000 83.32320  ? 130 GLU B CB   1 
ATOM   2461 C CG   . GLU B 1 131 ? -18.67219 -11.80495 9.40240   1.000 92.16587  ? 130 GLU B CG   1 
ATOM   2462 C CD   . GLU B 1 131 ? -18.95726 -13.27794 9.15442   1.000 85.90196  ? 130 GLU B CD   1 
ATOM   2463 O OE1  . GLU B 1 131 ? -18.43546 -13.83093 8.16630   1.000 88.34736  ? 130 GLU B OE1  1 
ATOM   2464 O OE2  . GLU B 1 131 ? -19.70412 -13.87095 9.95355   1.000 96.77917  ? 130 GLU B OE2  1 
ATOM   2465 N N    . TRP B 1 132 ? -17.66984 -9.25089  5.78326   1.000 52.43642  ? 131 TRP B N    1 
ATOM   2466 C CA   . TRP B 1 132 ? -16.80203 -8.64688  4.74611   1.000 46.08341  ? 131 TRP B CA   1 
ATOM   2467 C C    . TRP B 1 132 ? -16.92799 -7.13388  4.85817   1.000 49.12018  ? 131 TRP B C    1 
ATOM   2468 O O    . TRP B 1 132 ? -15.90397 -6.46590  4.90799   1.000 54.05932  ? 131 TRP B O    1 
ATOM   2469 C CB   . TRP B 1 132 ? -17.21531 -9.14484  3.36018   1.000 44.80370  ? 131 TRP B CB   1 
ATOM   2470 C CG   . TRP B 1 132 ? -16.38651 -8.60783  2.23503   1.000 57.68579  ? 131 TRP B CG   1 
ATOM   2471 C CD1  . TRP B 1 132 ? -15.18560 -9.08884  1.80679   1.000 51.12332  ? 131 TRP B CD1  1 
ATOM   2472 C CD2  . TRP B 1 132 ? -16.69766 -7.49180  1.37911   1.000 57.91793  ? 131 TRP B CD2  1 
ATOM   2473 N NE1  . TRP B 1 132 ? -14.72779 -8.34882  0.75372   1.000 50.46403  ? 131 TRP B NE1  1 
ATOM   2474 C CE2  . TRP B 1 132 ? -15.62983 -7.36580  0.46691   1.000 50.49735  ? 131 TRP B CE2  1 
ATOM   2475 C CE3  . TRP B 1 132 ? -17.76066 -6.59078  1.29434   1.000 60.79722  ? 131 TRP B CE3  1 
ATOM   2476 C CZ2  . TRP B 1 132 ? -15.59500 -6.37378  -0.50907  1.000 50.26754  ? 131 TRP B CZ2  1 
ATOM   2477 C CZ3  . TRP B 1 132 ? -17.73283 -5.61576  0.32335   1.000 52.53647  ? 131 TRP B CZ3  1 
ATOM   2478 C CH2  . TRP B 1 132 ? -16.66200 -5.50776  -0.56185  1.000 55.33055  ? 131 TRP B CH2  1 
ATOM   2479 N N    . TYR B 1 133 ? -18.16096 -6.65086  4.94641   1.000 45.73184  ? 132 TYR B N    1 
ATOM   2480 C CA   . TYR B 1 133 ? -18.41892 -5.20186  5.03750   1.000 60.30014  ? 132 TYR B CA   1 
ATOM   2481 C C    . TYR B 1 133 ? -17.78167 -4.65190  6.31639   1.000 57.86797  ? 132 TYR B C    1 
ATOM   2482 O O    . TYR B 1 133 ? -17.33965 -3.51990  6.29433   1.000 51.08549  ? 132 TYR B O    1 
ATOM   2483 C CB   . TYR B 1 133 ? -19.92294 -4.95083  4.93679   1.000 55.51986  ? 132 TYR B CB   1 
ATOM   2484 C CG   . TYR B 1 133 ? -20.32992 -3.50482  4.90290   1.000 62.85750  ? 132 TYR B CG   1 
ATOM   2485 C CD1  . TYR B 1 133 ? -19.72807 -2.61281  4.03380   1.000 55.79482  ? 132 TYR B CD1  1 
ATOM   2486 C CD2  . TYR B 1 133 ? -21.32375 -3.02483  5.74010   1.000 65.00247  ? 132 TYR B CD2  1 
ATOM   2487 C CE1  . TYR B 1 133 ? -20.09805 -1.28181  3.99690   1.000 52.16228  ? 132 TYR B CE1  1 
ATOM   2488 C CE2  . TYR B 1 133 ? -21.71173 -1.69382  5.70920   1.000 65.23461  ? 132 TYR B CE2  1 
ATOM   2489 C CZ   . TYR B 1 133 ? -21.09489 -0.82081  4.83411   1.000 53.40983  ? 132 TYR B CZ   1 
ATOM   2490 O OH   . TYR B 1 133 ? -21.45687 0.49220   4.80420   1.000 57.88132  ? 132 TYR B OH   1 
ATOM   2491 N N    . GLU B 1 134 ? -17.70348 -5.46092  7.36435   1.000 57.88645  ? 133 GLU B N    1 
ATOM   2492 C CA   . GLU B 1 134 ? -17.09423 -5.01496  8.64225   1.000 60.96164  ? 133 GLU B CA   1 
ATOM   2493 C C    . GLU B 1 134 ? -15.60226 -4.75898  8.43197   1.000 59.47120  ? 133 GLU B C    1 
ATOM   2494 O O    . GLU B 1 134 ? -15.14016 -3.70000  8.85990   1.000 55.36920  ? 133 GLU B O    1 
ATOM   2495 C CB   . GLU B 1 134 ? -17.34703 -6.04098  9.73927   1.000 53.68028  ? 133 GLU B CB   1 
ATOM   2496 C CG   . GLU B 1 134 ? -16.47080 -5.85202  10.96011  1.000 79.86149  ? 133 GLU B CG   1 
ATOM   2497 C CD   . GLU B 1 134 ? -16.00469 -7.14205  11.61099  1.000 87.12075  ? 133 GLU B CD   1 
ATOM   2498 O OE1  . GLU B 1 134 ? -15.70485 -8.10703  10.87591  1.000 94.66067  ? 133 GLU B OE1  1 
ATOM   2499 O OE2  . GLU B 1 134 ? -15.93946 -7.17607  12.85498  1.000 99.03118  ? 133 GLU B OE2  1 
ATOM   2500 N N    . ILE B 1 135 ? -14.89940 -5.67898  7.77281   1.000 52.41013  ? 134 ILE B N    1 
ATOM   2501 C CA   . ILE B 1 135 ? -13.45546 -5.48399  7.46554   1.000 55.71599  ? 134 ILE B CA   1 
ATOM   2502 C C    . ILE B 1 135 ? -13.28962 -4.27498  6.54753   1.000 46.17757  ? 134 ILE B C    1 
ATOM   2503 O O    . ILE B 1 135 ? -12.40955 -3.47500  6.82238   1.000 50.51930  ? 134 ILE B O    1 
ATOM   2504 C CB   . ILE B 1 135 ? -12.82860 -6.75199  6.85139   1.000 62.97128  ? 134 ILE B CB   1 
ATOM   2505 C CG1  . ILE B 1 135 ? -13.11246 -7.99201  7.70142   1.000 69.09388  ? 134 ILE B CG1  1 
ATOM   2506 C CG2  . ILE B 1 135 ? -11.34164 -6.56301  6.61311   1.000 53.13311  ? 134 ILE B CG2  1 
ATOM   2507 C CD1  . ILE B 1 135 ? -13.25563 -9.25698  6.88742   1.000 70.60820  ? 134 ILE B CD1  1 
ATOM   2508 N N    . VAL B 1 136 ? -14.10381 -4.16894  5.49969   1.000 44.67566  ? 135 VAL B N    1 
ATOM   2509 C CA   . VAL B 1 136 ? -13.95699 -3.06292  4.50969   1.000 48.52594  ? 135 VAL B CA   1 
ATOM   2510 C C    . VAL B 1 136 ? -14.17883 -1.72393  5.20976   1.000 45.64982  ? 135 VAL B C    1 
ATOM   2511 O O    . VAL B 1 136 ? -13.44087 -0.81094  4.90964   1.000 55.12871  ? 135 VAL B O    1 
ATOM   2512 C CB   . VAL B 1 136 ? -14.87722 -3.21688  3.27986   1.000 51.54558  ? 135 VAL B CB   1 
ATOM   2513 C CG1  . VAL B 1 136 ? -14.83336 -4.61186  2.68082   1.000 61.24759  ? 135 VAL B CG1  1 
ATOM   2514 C CG2  . VAL B 1 136 ? -16.30017 -2.74486  3.49414   1.000 64.45656  ? 135 VAL B CG2  1 
ATOM   2515 N N    . ARG B 1 137 ? -15.14666 -1.63694  6.10695   1.000 47.05497  ? 136 ARG B N    1 
ATOM   2516 C CA   . ARG B 1 137 ? -15.44951 -0.35195  6.77804   1.000 50.23399  ? 136 ARG B CA   1 
ATOM   2517 C C    . ARG B 1 137 ? -14.24334 0.06802   7.62481   1.000 45.78719  ? 136 ARG B C    1 
ATOM   2518 O O    . ARG B 1 137 ? -13.92032 1.25501   7.63478   1.000 47.68669  ? 136 ARG B O    1 
ATOM   2519 C CB   . ARG B 1 137 ? -16.72535 -0.47094  7.61128   1.000 52.34746  ? 136 ARG B CB   1 
ATOM   2520 C CG   . ARG B 1 137 ? -18.00251 -0.52490  6.78752   1.000 61.20141  ? 136 ARG B CG   1 
ATOM   2521 C CD   . ARG B 1 137 ? -19.23835 -0.75290  7.63675   1.000 71.11357  ? 136 ARG B CD   1 
ATOM   2522 N NE   . ARG B 1 137 ? -19.12620 -1.92592  8.49170   1.000 72.95444  ? 136 ARG B NE   1 
ATOM   2523 C CZ   . ARG B 1 137 ? -19.33395 -1.92195  9.80274   1.000 77.58460  ? 136 ARG B CZ   1 
ATOM   2524 N NH1  . ARG B 1 137 ? -19.66982 -0.80196  10.41383  1.000 80.16509  ? 136 ARG B NH1  1 
ATOM   2525 N NH2  . ARG B 1 137 ? -19.20384 -3.03697  10.49669  1.000 63.25828  ? 136 ARG B NH2  1 
ATOM   2526 N N    . GLU B 1 138 ? -13.59123 -0.89201  8.27167   1.000 49.56034  ? 137 GLU B N    1 
ATOM   2527 C CA   . GLU B 1 138 ? -12.42206 -0.57505  9.12545   1.000 54.53429  ? 137 GLU B CA   1 
ATOM   2528 C C    . GLU B 1 138 ? -11.29122 -0.02905  8.25225   1.000 43.69822  ? 137 GLU B C    1 
ATOM   2529 O O    . GLU B 1 138 ? -10.69013 0.97793   8.63115   1.000 41.14670  ? 137 GLU B O    1 
ATOM   2530 C CB   . GLU B 1 138 ? -11.98693 -1.81507  9.90434   1.000 49.05070  ? 137 GLU B CB   1 
ATOM   2531 C CG   . GLU B 1 138 ? -13.06177 -2.37308  10.81453  1.000 66.91747  ? 137 GLU B CG   1 
ATOM   2532 C CD   . GLU B 1 138 ? -12.74368 -3.74309  11.39544  1.000 82.72953  ? 137 GLU B CD   1 
ATOM   2533 O OE1  . GLU B 1 138 ? -11.96781 -4.48309  10.76628  1.000 72.50012  ? 137 GLU B OE1  1 
ATOM   2534 O OE2  . GLU B 1 138 ? -13.27548 -4.06211  12.47554  1.000 92.17085  ? 137 GLU B OE2  1 
ATOM   2535 N N    . LEU B 1 139 ? -11.02645 -0.68203  7.12618   1.000 37.38088  ? 138 LEU B N    1 
ATOM   2536 C CA   . LEU B 1 139 ? -9.93161  -0.23902  6.23198   1.000 41.58256  ? 138 LEU B CA   1 
ATOM   2537 C C    . LEU B 1 139 ? -10.23969 1.15199   5.68207   1.000 32.52860  ? 138 LEU B C    1 
ATOM   2538 O O    . LEU B 1 139 ? -9.31869  1.95198   5.60391   1.000 35.91530  ? 138 LEU B O    1 
ATOM   2539 C CB   . LEU B 1 139 ? -9.78184  -1.26500  5.10693   1.000 33.52128  ? 138 LEU B CB   1 
ATOM   2540 C CG   . LEU B 1 139 ? -9.37178  -2.66902  5.54382   1.000 44.82683  ? 138 LEU B CG   1 
ATOM   2541 C CD1  . LEU B 1 139 ? -9.39702  -3.62199  4.36180   1.000 45.91118  ? 138 LEU B CD1  1 
ATOM   2542 C CD2  . LEU B 1 139 ? -7.99666  -2.65406  6.18256   1.000 41.81781  ? 138 LEU B CD2  1 
ATOM   2543 N N    . LEU B 1 140 ? -11.49775 1.41002   5.34532   1.000 33.33228  ? 139 LEU B N    1 
ATOM   2544 C CA   . LEU B 1 140 ? -11.91284 2.71604   4.77443   1.000 36.99015  ? 139 LEU B CA   1 
ATOM   2545 C C    . LEU B 1 140 ? -11.74062 3.82101   5.81542   1.000 31.60482  ? 139 LEU B C    1 
ATOM   2546 O O    . LEU B 1 140 ? -11.27467 4.89602   5.45035   1.000 39.50138  ? 139 LEU B O    1 
ATOM   2547 C CB   . LEU B 1 140 ? -13.36993 2.60007   4.32870   1.000 38.97185  ? 139 LEU B CB   1 
ATOM   2548 C CG   . LEU B 1 140 ? -13.62818 1.72211   3.10273   1.000 58.89483  ? 139 LEU B CG   1 
ATOM   2549 C CD1  . LEU B 1 140 ? -15.11822 1.52814   2.89101   1.000 52.36493  ? 139 LEU B CD1  1 
ATOM   2550 C CD2  . LEU B 1 140 ? -12.98640 2.31912   1.86262   1.000 51.03728  ? 139 LEU B CD2  1 
ATOM   2551 N N    . GLU B 1 141 ? -12.05339 3.52199   7.07347   1.000 38.46964  ? 140 GLU B N    1 
ATOM   2552 C CA   . GLU B 1 141 ? -11.91116 4.51596   8.16547   1.000 55.88564  ? 140 GLU B CA   1 
ATOM   2553 C C    . GLU B 1 141 ? -10.43911 4.86394   8.38919   1.000 48.18518  ? 140 GLU B C    1 
ATOM   2554 O O    . GLU B 1 141 ? -10.13307 6.05093   8.51116   1.000 37.41699  ? 140 GLU B O    1 
ATOM   2555 C CB   . GLU B 1 141 ? -12.53392 3.98195   9.45458   1.000 46.12188  ? 140 GLU B CB   1 
ATOM   2556 C CG   . GLU B 1 141 ? -12.97672 5.08193   10.40268  1.000 69.59740  ? 140 GLU B CG   1 
ATOM   2557 C CD   . GLU B 1 141 ? -13.43683 6.36495   9.72780   1.000 75.31667  ? 140 GLU B CD   1 
ATOM   2558 O OE1  . GLU B 1 141 ? -14.53394 6.36199   9.14801   1.000 74.34051  ? 140 GLU B OE1  1 
ATOM   2559 O OE2  . GLU B 1 141 ? -12.68880 7.36194   9.78168   1.000 70.79395  ? 140 GLU B OE2  1 
ATOM   2560 N N    . ARG B 1 142 ? -9.57412  3.85692   8.43301   1.000 34.58145  ? 141 ARG B N    1 
ATOM   2561 C CA   . ARG B 1 142 ? -8.12809  4.13389   8.57174   1.000 38.45823  ? 141 ARG B CA   1 
ATOM   2562 C C    . ARG B 1 142 ? -7.66031  4.94691   7.36366   1.000 30.10622  ? 141 ARG B C    1 
ATOM   2563 O O    . ARG B 1 142 ? -6.93525  5.91590   7.56455   1.000 34.00550  ? 141 ARG B O    1 
ATOM   2564 C CB   . ARG B 1 142 ? -7.33209  2.83788   8.69555   1.000 31.29212  ? 141 ARG B CB   1 
ATOM   2565 C CG   . ARG B 1 142 ? -5.83905  3.05285   8.88027   1.000 45.51699  ? 141 ARG B CG   1 
ATOM   2566 C CD   . ARG B 1 142 ? -5.52679  3.80681   10.15723  1.000 32.86904  ? 141 ARG B CD   1 
ATOM   2567 N NE   . ARG B 1 142 ? -4.21479  4.42779   10.12199  1.000 41.56002  ? 141 ARG B NE   1 
ATOM   2568 C CZ   . ARG B 1 142 ? -3.94667  5.62478   10.61897  1.000 42.15141  ? 141 ARG B CZ   1 
ATOM   2569 N NH1  . ARG B 1 142 ? -4.90655  6.32578   11.19717  1.000 32.94381  ? 141 ARG B NH1  1 
ATOM   2570 N NH2  . ARG B 1 142 ? -2.72568  6.11876   10.54075  1.000 43.95109  ? 141 ARG B NH2  1 
ATOM   2571 N N    . ALA B 1 143 ? -8.07854  4.55495   6.16974   1.000 33.01199  ? 142 ALA B N    1 
ATOM   2572 C CA   . ALA B 1 143 ? -7.64177  5.24497   4.93867   1.000 40.82131  ? 142 ALA B CA   1 
ATOM   2573 C C    . ALA B 1 143 ? -8.00173  6.72597   5.00577   1.000 30.04625  ? 142 ALA B C    1 
ATOM   2574 O O    . ALA B 1 143 ? -7.14077  7.54396   4.71662   1.000 38.45427  ? 142 ALA B O    1 
ATOM   2575 C CB   . ALA B 1 143 ? -8.28900  4.59500   3.75978   1.000 41.39579  ? 142 ALA B CB   1 
ATOM   2576 N N    . LYS B 1 144 ? -9.23966  7.03598   5.36701   1.000 40.37718  ? 143 LYS B N    1 
ATOM   2577 C CA   . LYS B 1 144 ? -9.67360  8.44599   5.51313   1.000 50.66240  ? 143 LYS B CA   1 
ATOM   2578 C C    . LYS B 1 144 ? -8.75340  9.17195   6.50097   1.000 41.21924  ? 143 LYS B C    1 
ATOM   2579 O O    . LYS B 1 144 ? -8.33545  10.27595  6.18591   1.000 31.05592  ? 143 LYS B O    1 
ATOM   2580 C CB   . LYS B 1 144 ? -11.12651 8.51000   5.98541   1.000 46.93125  ? 143 LYS B CB   1 
ATOM   2581 C CG   . LYS B 1 144 ? -12.18672 8.47004   4.90261   1.000 55.25219  ? 143 LYS B CG   1 
ATOM   2582 C CD   . LYS B 1 144 ? -13.54561 8.18005   5.48386   1.000 73.96386  ? 143 LYS B CD   1 
ATOM   2583 C CE   . LYS B 1 144 ? -14.31452 9.43206   5.84504   1.000 74.08652  ? 143 LYS B CE   1 
ATOM   2584 N NZ   . LYS B 1 144 ? -15.77456 9.24308   5.67431   1.000 83.59241  ? 143 LYS B NZ   1 
ATOM   2585 N N    . GLU B 1 145 ? -8.43020  8.52992   7.62389   1.000 34.44294  ? 144 GLU B N    1 
ATOM   2586 C CA   . GLU B 1 145 ? -7.54999  9.14788   8.64774   1.000 38.10456  ? 144 GLU B CA   1 
ATOM   2587 C C    . GLU B 1 145 ? -6.18210  9.46287   8.03548   1.000 33.58495  ? 144 GLU B C    1 
ATOM   2588 O O    . GLU B 1 145 ? -5.69305  10.56686  8.24041   1.000 31.34918  ? 144 GLU B O    1 
ATOM   2589 C CB   . GLU B 1 145 ? -7.45877  8.23085   9.86370   1.000 31.34804  ? 144 GLU B CB   1 
ATOM   2590 C CG   . GLU B 1 145 ? -8.78565  7.97186   10.54995  1.000 37.77241  ? 144 GLU B CG   1 
ATOM   2591 C CD   . GLU B 1 145 ? -8.78847  6.83884   11.56492  1.000 37.22265  ? 144 GLU B CD   1 
ATOM   2592 O OE1  . GLU B 1 145 ? -7.79447  6.09682   11.62572  1.000 34.09618  ? 144 GLU B OE1  1 
ATOM   2593 O OE2  . GLU B 1 145 ? -9.77934  6.70684   12.28911  1.000 44.12024  ? 144 GLU B OE2  1 
ATOM   2594 N N    . ILE B 1 146 ? -5.62326  8.52688   7.27735   1.000 32.08126  ? 145 ILE B N    1 
ATOM   2595 C CA   . ILE B 1 146 ? -4.29539  8.72787   6.62410   1.000 41.48267  ? 145 ILE B CA   1 
ATOM   2596 C C    . ILE B 1 146 ? -4.38856  9.87490   5.62015   1.000 21.37644  ? 145 ILE B C    1 
ATOM   2597 O O    . ILE B 1 146 ? -3.51554  10.73188  5.62800   1.000 29.18131  ? 145 ILE B O    1 
ATOM   2598 C CB   . ILE B 1 146 ? -3.81854  7.42188   5.94998   1.000 44.23853  ? 145 ILE B CB   1 
ATOM   2599 C CG1  . ILE B 1 146 ? -3.42336  6.36585   6.98788   1.000 36.45196  ? 145 ILE B CG1  1 
ATOM   2600 C CG2  . ILE B 1 146 ? -2.69472  7.69788   4.96878   1.000 33.86458  ? 145 ILE B CG2  1 
ATOM   2601 C CD1  . ILE B 1 146 ? -3.46948  4.94986   6.47286   1.000 37.09284  ? 145 ILE B CD1  1 
ATOM   2602 N N    . ILE B 1 147 ? -5.42872  9.85993   4.79535   1.000 32.71175  ? 146 ILE B N    1 
ATOM   2603 C CA   . ILE B 1 147 ? -5.59290  10.90096  3.74140   1.000 37.79136  ? 146 ILE B CA   1 
ATOM   2604 C C    . ILE B 1 147 ? -5.63775  12.25995  4.43044   1.000 39.03583  ? 146 ILE B C    1 
ATOM   2605 O O    . ILE B 1 147 ? -4.96982  13.18194  3.95933   1.000 36.02298  ? 146 ILE B O    1 
ATOM   2606 C CB   . ILE B 1 147 ? -6.85707  10.61700  2.91064   1.000 40.05968  ? 146 ILE B CB   1 
ATOM   2607 C CG1  . ILE B 1 147 ? -6.68726  9.38302   2.02158   1.000 35.64103  ? 146 ILE B CG1  1 
ATOM   2608 C CG2  . ILE B 1 147 ? -7.26720  11.83902  2.10574   1.000 36.31795  ? 146 ILE B CG2  1 
ATOM   2609 C CD1  . ILE B 1 147 ? -7.95931  8.60104   1.81880   1.000 41.72065  ? 146 ILE B CD1  1 
ATOM   2610 N N    . GLU B 1 148 ? -6.36854  12.34393  5.52958   1.000 35.47297  ? 147 GLU B N    1 
ATOM   2611 C CA   . GLU B 1 148 ? -6.50437  13.61792  6.26664   1.000 29.51321  ? 147 GLU B CA   1 
ATOM   2612 C C    . GLU B 1 148 ? -5.15126  14.05588  6.84539   1.000 27.15645  ? 147 GLU B C    1 
ATOM   2613 O O    . GLU B 1 148 ? -4.81726  15.22688  6.70335   1.000 35.10955  ? 147 GLU B O    1 
ATOM   2614 C CB   . GLU B 1 148 ? -7.60418  13.46591  7.31285   1.000 42.45893  ? 147 GLU B CB   1 
ATOM   2615 C CG   . GLU B 1 148 ? -8.99329  13.40495  6.70111   1.000 42.46790  ? 147 GLU B CG   1 
ATOM   2616 C CD   . GLU B 1 148 ? -10.08813 12.89495  7.61431   1.000 60.38428  ? 147 GLU B CD   1 
ATOM   2617 O OE1  . GLU B 1 148 ? -9.76394  12.28892  8.65223   1.000 65.11163  ? 147 GLU B OE1  1 
ATOM   2618 O OE2  . GLU B 1 148 ? -11.26819 13.10197  7.28154   1.000 57.40661  ? 147 GLU B OE2  1 
ATOM   2619 N N    . GLU B 1 149 ? -4.39116  13.14286  7.44622   1.000 26.71538  ? 148 GLU B N    1 
ATOM   2620 C CA   . GLU B 1 149 ? -3.05205  13.51482  7.96097   1.000 31.31955  ? 148 GLU B CA   1 
ATOM   2621 C C    . GLU B 1 149 ? -2.15326  14.02183  6.82481   1.000 25.24348  ? 148 GLU B C    1 
ATOM   2622 O O    . GLU B 1 149 ? -1.44120  14.98982  7.04870   1.000 28.25329  ? 148 GLU B O    1 
ATOM   2623 C CB   . GLU B 1 149 ? -2.38993  12.36280  8.70782   1.000 25.26160  ? 148 GLU B CB   1 
ATOM   2624 C CG   . GLU B 1 149 ? -1.13378  12.78776  9.43759   1.000 29.38752  ? 148 GLU B CG   1 
ATOM   2625 C CD   . GLU B 1 149 ? -1.38956  13.84374  10.49266  1.000 41.63519  ? 148 GLU B CD   1 
ATOM   2626 O OE1  . GLU B 1 149 ? -2.36742  13.69274  11.23485  1.000 34.92850  ? 148 GLU B OE1  1 
ATOM   2627 O OE2  . GLU B 1 149 ? -0.61253  14.80572  10.56654  1.000 32.12339  ? 148 GLU B OE2  1 
ATOM   2628 N N    . ILE B 1 150 ? -2.18049  13.36586  5.66780   1.000 28.32001  ? 149 ILE B N    1 
ATOM   2629 C CA   . ILE B 1 150 ? -1.33571  13.77887  4.51065   1.000 30.41997  ? 149 ILE B CA   1 
ATOM   2630 C C    . ILE B 1 150 ? -1.68275  15.21989  4.15375   1.000 23.13728  ? 149 ILE B C    1 
ATOM   2631 O O    . ILE B 1 150 ? -0.76676  16.01887  4.03159   1.000 37.68064  ? 149 ILE B O    1 
ATOM   2632 C CB   . ILE B 1 150 ? -1.50695  12.82790  3.31166   1.000 25.65385  ? 149 ILE B CB   1 
ATOM   2633 C CG1  . ILE B 1 150 ? -0.85292  11.47289  3.58651   1.000 31.83751  ? 149 ILE B CG1  1 
ATOM   2634 C CG2  . ILE B 1 150 ? -0.97719  13.46492  2.03958   1.000 27.97433  ? 149 ILE B CG2  1 
ATOM   2635 C CD1  . ILE B 1 150 ? -1.58806  10.30091  2.99062   1.000 34.73100  ? 149 ILE B CD1  1 
ATOM   2636 N N    . GLU B 1 151 ? -2.96978  15.50791  4.00800   1.000 32.56344  ? 150 GLU B N    1 
ATOM   2637 C CA   . GLU B 1 151 ? -3.40881  16.88293  3.69212   1.000 35.40482  ? 150 GLU B CA   1 
ATOM   2638 C C    . GLU B 1 151 ? -2.76561  17.84289  4.69402   1.000 48.06879  ? 150 GLU B C    1 
ATOM   2639 O O    . GLU B 1 151 ? -2.14367  18.81789  4.26492   1.000 32.73040  ? 150 GLU B O    1 
ATOM   2640 C CB   . GLU B 1 151 ? -4.93181  16.96795  3.71441   1.000 39.39974  ? 150 GLU B CB   1 
ATOM   2641 C CG   . GLU B 1 151 ? -5.61803  16.16699  2.62553   1.000 56.99365  ? 150 GLU B CG   1 
ATOM   2642 C CD   . GLU B 1 151 ? -7.12604  16.34401  2.57182   1.000 67.65747  ? 150 GLU B CD   1 
ATOM   2643 O OE1  . GLU B 1 151 ? -7.75583  16.32000  3.64694   1.000 69.47926  ? 150 GLU B OE1  1 
ATOM   2644 O OE2  . GLU B 1 151 ? -7.66925  16.50005  1.46593   1.000 58.29042  ? 150 GLU B OE2  1 
ATOM   2645 N N    . ARG B 1 152 ? -2.87436  17.54286  5.98603   1.000 34.45346  ? 151 ARG B N    1 
ATOM   2646 C CA   . ARG B 1 152 ? -2.34815  18.45483  7.02595   1.000 34.22142  ? 151 ARG B CA   1 
ATOM   2647 C C    . ARG B 1 152 ? -0.84218  18.63481  6.83967   1.000 30.39869  ? 151 ARG B C    1 
ATOM   2648 O O    . ARG B 1 152 ? -0.37316  19.77080  6.87360   1.000 32.57133  ? 151 ARG B O    1 
ATOM   2649 C CB   . ARG B 1 152 ? -2.71590  17.88381  8.39301   1.000 42.57638  ? 151 ARG B CB   1 
ATOM   2650 C CG   . ARG B 1 152 ? -2.26965  18.71177  9.58794   1.000 48.43837  ? 151 ARG B CG   1 
ATOM   2651 C CD   . ARG B 1 152 ? -2.73242  18.02575  10.86002  1.000 47.05266  ? 151 ARG B CD   1 
ATOM   2652 N NE   . ARG B 1 152 ? -2.32619  18.78472  12.02695  1.000 33.37168  ? 151 ARG B NE   1 
ATOM   2653 C CZ   . ARG B 1 152 ? -1.14708  18.66269  12.61473  1.000 39.41759  ? 151 ARG B CZ   1 
ATOM   2654 N NH1  . ARG B 1 152 ? -0.26418  17.79768  12.14854  1.000 34.78944  ? 151 ARG B NH1  1 
ATOM   2655 N NH2  . ARG B 1 152 ? -0.85686  19.40266  13.66569  1.000 54.93623  ? 151 ARG B NH2  1 
ATOM   2656 N N    . LEU B 1 153 ? -0.12424  17.53680  6.64650   1.000 30.76381  ? 152 LEU B N    1 
ATOM   2657 C CA   . LEU B 1 153 ? 1.34974   17.58978  6.50322   1.000 37.20357  ? 152 LEU B CA   1 
ATOM   2658 C C    . LEU B 1 153 ? 1.74651   18.39781  5.25517   1.000 30.43906  ? 152 LEU B C    1 
ATOM   2659 O O    . LEU B 1 153 ? 2.74753   19.10779  5.31699   1.000 33.50518  ? 152 LEU B O    1 
ATOM   2660 C CB   . LEU B 1 153 ? 1.86670   16.15278  6.44409   1.000 27.03460  ? 152 LEU B CB   1 
ATOM   2661 C CG   . LEU B 1 153 ? 1.62593   15.31275  7.69712   1.000 41.52455  ? 152 LEU B CG   1 
ATOM   2662 C CD1  . LEU B 1 153 ? 2.36589   13.98874  7.60795   1.000 34.82119  ? 152 LEU B CD1  1 
ATOM   2663 C CD2  . LEU B 1 153 ? 2.04318   16.07072  8.94406   1.000 39.68519  ? 152 LEU B CD2  1 
ATOM   2664 N N    . LEU B 1 154 ? 0.98230   18.27084  4.17531   1.000 29.95409  ? 153 LEU B N    1 
ATOM   2665 C CA   . LEU B 1 154 ? 1.28207   19.00987  2.92327   1.000 35.54743  ? 153 LEU B CA   1 
ATOM   2666 C C    . LEU B 1 154 ? 1.18316   20.51086  3.21832   1.000 31.66718  ? 153 LEU B C    1 
ATOM   2667 O O    . LEU B 1 154 ? 2.08810   21.25485  2.84016   1.000 32.15757  ? 153 LEU B O    1 
ATOM   2668 C CB   . LEU B 1 154 ? 0.29586   18.55491  1.84345   1.000 22.11029  ? 153 LEU B CB   1 
ATOM   2669 C CG   . LEU B 1 154 ? 0.47074   17.11491  1.36238   1.000 35.02781  ? 153 LEU B CG   1 
ATOM   2670 C CD1  . LEU B 1 154 ? -0.52047  16.78195  0.26256   1.000 27.71553  ? 153 LEU B CD1  1 
ATOM   2671 C CD2  . LEU B 1 154 ? 1.89265   16.87190  0.89510   1.000 28.03102  ? 153 LEU B CD2  1 
ATOM   2672 N N    . ARG B 1 155 ? 0.12630   20.91586  3.91453   1.000 39.15395  ? 154 ARG B N    1 
ATOM   2673 C CA   . ARG B 1 155 ? -0.06061  22.33886  4.29860   1.000 42.50704  ? 154 ARG B CA   1 
ATOM   2674 C C    . ARG B 1 155 ? 1.10557   22.80382  5.18039   1.000 37.02477  ? 154 ARG B C    1 
ATOM   2675 O O    . ARG B 1 155 ? 1.61254   23.89881  4.95732   1.000 38.96114  ? 154 ARG B O    1 
ATOM   2676 C CB   . ARG B 1 155 ? -1.41247  22.49986  4.99186   1.000 45.06278  ? 154 ARG B CB   1 
ATOM   2677 C CG   . ARG B 1 155 ? -2.58665  22.65090  4.03709   1.000 58.63461  ? 154 ARG B CG   1 
ATOM   2678 C CD   . ARG B 1 155 ? -3.77959  21.80291  4.42730   1.000 57.24082  ? 154 ARG B CD   1 
ATOM   2679 N NE   . ARG B 1 155 ? -4.70081  21.60595  3.31647   1.000 69.01419  ? 154 ARG B NE   1 
ATOM   2680 C CZ   . ARG B 1 155 ? -4.49902  20.77397  2.29941   1.000 71.16677  ? 154 ARG B CZ   1 
ATOM   2681 N NH1  . ARG B 1 155 ? -3.39804  20.04696  2.24219   1.000 47.46864  ? 154 ARG B NH1  1 
ATOM   2682 N NH2  . ARG B 1 155 ? -5.39920  20.67401  1.33859   1.000 80.96924  ? 154 ARG B NH2  1 
ATOM   2683 N N    . ARG B 1 156 ? 1.51974   21.97379  6.13129   1.000 38.90048  ? 155 ARG B N    1 
ATOM   2684 C CA   . ARG B 1 156 ? 2.63192   22.33775  7.04109   1.000 42.38362  ? 155 ARG B CA   1 
ATOM   2685 C C    . ARG B 1 156 ? 3.93577   22.56775  6.26884   1.000 35.71555  ? 155 ARG B C    1 
ATOM   2686 O O    . ARG B 1 156 ? 4.64485   23.50573  6.60673   1.000 46.12540  ? 155 ARG B O    1 
ATOM   2687 C CB   . ARG B 1 156 ? 2.84810   21.25172  8.09002   1.000 31.76681  ? 155 ARG B CB   1 
ATOM   2688 C CG   . ARG B 1 156 ? 4.10726   21.45468  8.91778   1.000 48.72252  ? 155 ARG B CG   1 
ATOM   2689 C CD   . ARG B 1 156 ? 3.97345   22.66967  9.81684   1.000 62.18932  ? 155 ARG B CD   1 
ATOM   2690 N NE   . ARG B 1 156 ? 3.01766   22.43366  10.89001  1.000 46.94089  ? 155 ARG B NE   1 
ATOM   2691 C CZ   . ARG B 1 156 ? 3.20783   21.57963  11.88696  1.000 73.70758  ? 155 ARG B CZ   1 
ATOM   2692 N NH1  . ARG B 1 156 ? 4.32583   20.87961  11.95373  1.000 68.03636  ? 155 ARG B NH1  1 
ATOM   2693 N NH2  . ARG B 1 156 ? 2.28201   21.43363  12.81513  1.000 62.75588  ? 155 ARG B NH2  1 
ATOM   2694 N N    . LEU B 1 157 ? 4.24657   21.71276  5.30076   1.000 38.55886  ? 156 LEU B N    1 
ATOM   2695 C CA   . LEU B 1 157 ? 5.46442   21.88376  4.47553   1.000 33.72847  ? 156 LEU B CA   1 
ATOM   2696 C C    . LEU B 1 157 ? 5.39630   23.22578  3.73758   1.000 32.34469  ? 156 LEU B C    1 
ATOM   2697 O O    . LEU B 1 157 ? 6.39931   23.93776  3.73240   1.000 37.58106  ? 156 LEU B O    1 
ATOM   2698 C CB   . LEU B 1 157 ? 5.57422   20.69778  3.51348   1.000 40.83460  ? 156 LEU B CB   1 
ATOM   2699 C CG   . LEU B 1 157 ? 6.05831   19.38176  4.10936   1.000 46.22554  ? 156 LEU B CG   1 
ATOM   2700 C CD1  . LEU B 1 157 ? 5.90510   18.25779  3.09737   1.000 37.61922  ? 156 LEU B CD1  1 
ATOM   2701 C CD2  . LEU B 1 157 ? 7.50240   19.49473  4.55909   1.000 44.25616  ? 156 LEU B CD2  1 
ATOM   2702 N N    . LEU B 1 158 ? 4.24020   23.56381  3.17580   1.000 29.04840  ? 157 LEU B N    1 
ATOM   2703 C CA   . LEU B 1 158 ? 4.06709   24.86583  2.48587   1.000 33.91450  ? 157 LEU B CA   1 
ATOM   2704 C C    . LEU B 1 158 ? 4.30729   26.01380  3.47085   1.000 40.31705  ? 157 LEU B C    1 
ATOM   2705 O O    . LEU B 1 158 ? 4.99424   26.95780  3.10774   1.000 36.54593  ? 157 LEU B O    1 
ATOM   2706 C CB   . LEU B 1 158 ? 2.66797   24.91087  1.87314   1.000 38.90255  ? 157 LEU B CB   1 
ATOM   2707 C CG   . LEU B 1 158 ? 2.51171   24.14890  0.55715   1.000 42.94486  ? 157 LEU B CG   1 
ATOM   2708 C CD1  . LEU B 1 158 ? 1.04863   24.00293  0.18243   1.000 49.06363  ? 157 LEU B CD1  1 
ATOM   2709 C CD2  . LEU B 1 158 ? 3.28050   24.83391  -0.55798  1.000 33.46335  ? 157 LEU B CD2  1 
ATOM   2710 N N    . GLU B 1 159 ? 3.81853   25.88778  4.70294   1.000 41.49977  ? 158 GLU B N    1 
ATOM   2711 C CA   . GLU B 1 159 ? 4.01474   26.93176  5.74392   1.000 43.32809  ? 158 GLU B CA   1 
ATOM   2712 C C    . GLU B 1 159 ? 5.48982   27.01872  6.14064   1.000 45.77284  ? 158 GLU B C    1 
ATOM   2713 O O    . GLU B 1 159 ? 6.02884   28.12572  6.11357   1.000 58.08410  ? 158 GLU B O    1 
ATOM   2714 C CB   . GLU B 1 159 ? 3.14497   26.61274  6.95608   1.000 44.73810  ? 158 GLU B CB   1 
ATOM   2715 C CG   . GLU B 1 159 ? 1.69390   26.35678  6.60036   1.000 58.40684  ? 158 GLU B CG   1 
ATOM   2716 C CD   . GLU B 1 159 ? 0.85309   25.67677  7.67150   1.000 71.43287  ? 158 GLU B CD   1 
ATOM   2717 O OE1  . GLU B 1 159 ? 1.42424   24.96274  8.51538   1.000 67.87655  ? 158 GLU B OE1  1 
ATOM   2718 O OE2  . GLU B 1 159 ? -0.37491  25.87079  7.65774   1.000 58.25254  ? 158 GLU B OE2  1 
ATOM   2719 N N    . ILE B 1 160 ? 6.10487   25.89271  6.50050   1.000 40.74751  ? 159 ILE B N    1 
ATOM   2720 C CA   . ILE B 1 160 ? 7.53695   25.84467  6.91123   1.000 38.88202  ? 159 ILE B CA   1 
ATOM   2721 C C    . ILE B 1 160 ? 8.40775   26.44868  5.81107   1.000 46.25789  ? 159 ILE B C    1 
ATOM   2722 O O    . ILE B 1 160 ? 9.40983   27.07666  6.15289   1.000 45.37747  ? 159 ILE B O    1 
ATOM   2723 C CB   . ILE B 1 160 ? 7.96498   24.39466  7.20911   1.000 39.30318  ? 159 ILE B CB   1 
ATOM   2724 C CG1  . ILE B 1 160 ? 7.30322   23.84164  8.47422   1.000 51.16125  ? 159 ILE B CG1  1 
ATOM   2725 C CG2  . ILE B 1 160 ? 9.47799   24.26463  7.27182   1.000 40.25134  ? 159 ILE B CG2  1 
ATOM   2726 C CD1  . ILE B 1 160 ? 7.66025   22.40263  8.76412   1.000 49.85493  ? 159 ILE B CD1  1 
ATOM   2727 N N    . LEU B 1 161 ? 8.03551   26.25372  4.54914   1.000 41.09591  ? 160 LEU B N    1 
ATOM   2728 C CA   . LEU B 1 161 ? 8.87630   26.74373  3.42899   1.000 45.27436  ? 160 LEU B CA   1 
ATOM   2729 C C    . LEU B 1 161 ? 8.52627   28.20474  3.13709   1.000 39.70881  ? 160 LEU B C    1 
ATOM   2730 O O    . LEU B 1 161 ? 9.25413   28.83475  2.37396   1.000 53.71543  ? 160 LEU B O    1 
ATOM   2731 C CB   . LEU B 1 161 ? 8.64205   25.84976  2.21401   1.000 33.90844  ? 160 LEU B CB   1 
ATOM   2732 C CG   . LEU B 1 161 ? 9.06406   24.39175  2.36690   1.000 36.99900  ? 160 LEU B CG   1 
ATOM   2733 C CD1  . LEU B 1 161 ? 8.52382   23.55978  1.21598   1.000 40.30521  ? 160 LEU B CD1  1 
ATOM   2734 C CD2  . LEU B 1 161 ? 10.57407  24.27272  2.44361   1.000 42.11850  ? 160 LEU B CD2  1 
ATOM   2735 N N    . GLY B 1 162 ? 7.46239   28.71574  3.75830   1.000 50.76963  ? 161 GLY B N    1 
ATOM   2736 C CA   . GLY B 1 162 ? 7.02437   30.09776  3.51442   1.000 57.11892  ? 161 GLY B CA   1 
ATOM   2737 C C    . GLY B 1 162 ? 6.35312   30.22080  2.17055   1.000 43.82540  ? 161 GLY B C    1 
ATOM   2738 O O    . GLY B 1 162 ? 6.46401   31.28181  1.55255   1.000 56.61267  ? 161 GLY B O    1 
ATOM   2739 N N    . LEU B 1 163 ? 5.68202   29.16382  1.74365   1.000 45.96214  ? 162 LEU B N    1 
ATOM   2740 C CA   . LEU B 1 163 ? 5.03676   29.16186  0.41278   1.000 55.16480  ? 162 LEU B CA   1 
ATOM   2741 C C    . LEU B 1 163 ? 3.53380   29.37788  0.60307   1.000 48.49871  ? 162 LEU B C    1 
ATOM   2742 O O    . LEU B 1 163 ? 2.80861   29.39391  -0.39779  1.000 56.59788  ? 162 LEU B O    1 
ATOM   2743 C CB   . LEU B 1 163 ? 5.36261   27.83287  -0.27831  1.000 45.32548  ? 162 LEU B CB   1 
ATOM   2744 C CG   . LEU B 1 163 ? 6.84055   27.58085  -0.55460  1.000 50.78735  ? 162 LEU B CG   1 
ATOM   2745 C CD1  . LEU B 1 163 ? 7.05142   26.18686  -1.12667  1.000 42.21180  ? 162 LEU B CD1  1 
ATOM   2746 C CD2  . LEU B 1 163 ? 7.39639   28.63086  -1.49569  1.000 49.63508  ? 162 LEU B CD2  1 
ATOM   2747 N N    . GLU B 1 164 ? 3.11104   29.57986  1.85116   1.000 52.33311  ? 163 GLU B N    1 
ATOM   2748 C CA   . GLU B 1 164 ? 1.68811   29.83587  2.19243   1.000 70.98695  ? 163 GLU B CA   1 
ATOM   2749 C C    . GLU B 1 164 ? 0.99392   30.64991  1.09759   1.000 86.68496  ? 163 GLU B C    1 
ATOM   2750 O O    . GLU B 1 164 ? 0.06100   31.40092  1.44278   1.000 93.47851  ? 163 GLU B O    1 
ATOM   2751 C CB   . GLU B 1 164 ? 1.63438   30.59985  3.51046   1.000 59.53289  ? 163 GLU B CB   1 
ATOM   2752 C CG   . GLU B 1 164 ? 1.12859   29.77183  4.67254   1.000 79.60051  ? 163 GLU B CG   1 
ATOM   2753 C CD   . GLU B 1 164 ? 1.04985   30.53180  5.98557   1.000 86.64968  ? 163 GLU B CD   1 
ATOM   2754 O OE1  . GLU B 1 164 ? 2.09698   30.68077  6.64138   1.000 92.81266  ? 163 GLU B OE1  1 
ATOM   2755 O OE2  . GLU B 1 164 ? -0.05907  30.97481  6.34479   1.000 80.71817  ? 163 GLU B OE2  1 
HETATM 2756 C C10  . KY6 C 2 .   ? 0.88074   6.53642   24.90199  1.000 51.74365  ? 201 KY6 A C10  1 
HETATM 2757 C C11  . KY6 C 2 .   ? -0.26549  6.94708   24.28219  1.000 42.18615  ? 201 KY6 A C11  1 
HETATM 2758 C C12  . KY6 C 2 .   ? -1.09259  8.01700   24.81120  1.000 27.68592  ? 201 KY6 A C12  1 
HETATM 2759 C C13  . KY6 C 2 .   ? -2.18384  8.65568   24.30235  1.000 38.95710  ? 201 KY6 A C13  1 
HETATM 2760 C C14  . KY6 C 2 .   ? -2.66406  8.23436   23.01554  1.000 48.98151  ? 201 KY6 A C14  1 
HETATM 2761 C C16  . KY6 C 2 .   ? -2.96691  9.75064   24.96434  1.000 43.87443  ? 201 KY6 A C16  1 
HETATM 2762 C C17  . KY6 C 2 .   ? -4.03719  10.38730  24.32549  1.000 29.41480  ? 201 KY6 A C17  1 
HETATM 2763 C C18  . KY6 C 2 .   ? -4.75425  11.40226  24.94448  1.000 38.67211  ? 201 KY6 A C18  1 
HETATM 2764 C C19  . KY6 C 2 .   ? -4.45802  11.75955  26.25035  1.000 40.51388  ? 201 KY6 A C19  1 
HETATM 2765 C C20  . KY6 C 2 .   ? -5.20108  12.81351  26.89734  1.000 36.44389  ? 201 KY6 A C20  1 
HETATM 2766 C C01  . KY6 C 2 .   ? 2.57250   2.34696   20.24631  1.000 51.30311  ? 201 KY6 A C01  1 
HETATM 2767 C C03  . KY6 C 2 .   ? 4.56992   2.05763   21.74889  1.000 47.13405  ? 201 KY6 A C03  1 
HETATM 2768 C C04  . KY6 C 2 .   ? 4.39439   0.82376   22.65215  1.000 48.02731  ? 201 KY6 A C04  1 
HETATM 2769 C C06  . KY6 C 2 .   ? 2.73373   3.67936   22.37304  1.000 35.50181  ? 201 KY6 A C06  1 
HETATM 2770 C C07  . KY6 C 2 .   ? 3.40394   4.05071   23.56982  1.000 53.58817  ? 201 KY6 A C07  1 
HETATM 2771 C C08  . KY6 C 2 .   ? 2.85496   4.98075   24.44579  1.000 50.60034  ? 201 KY6 A C08  1 
HETATM 2772 C C09  . KY6 C 2 .   ? 1.61676   5.56744   24.13598  1.000 49.69898  ? 201 KY6 A C09  1 
HETATM 2773 C C22  . KY6 C 2 .   ? -3.43872  11.11588  26.92522  1.000 40.85655  ? 201 KY6 A C22  1 
HETATM 2774 C C23  . KY6 C 2 .   ? -2.72167  10.11392  26.29322  1.000 49.19352  ? 201 KY6 A C23  1 
HETATM 2775 C C25  . KY6 C 2 .   ? 0.95355   5.20710   22.96220  1.000 42.26524  ? 201 KY6 A C25  1 
HETATM 2776 C C26  . KY6 C 2 .   ? 1.48353   4.28605   22.07324  1.000 39.49718  ? 201 KY6 A C26  1 
HETATM 2777 N N02  . KY6 C 2 .   ? 3.29071   2.74332   21.49107  1.000 43.62675  ? 201 KY6 A N02  1 
HETATM 2778 N N15  . KY6 C 2 .   ? -3.06523  7.87710   22.00469  1.000 35.41021  ? 201 KY6 A N15  1 
HETATM 2779 N N21  . KY6 C 2 .   ? -5.76115  13.68348  27.37232  1.000 38.70768  ? 201 KY6 A N21  1 
HETATM 2780 O O05  . KY6 C 2 .   ? 5.60458   0.06303   22.79599  1.000 70.12509  ? 201 KY6 A O05  1 
HETATM 2781 S S24  . KY6 C 2 .   ? -0.54466  6.05676   22.80541  1.000 34.67802  ? 201 KY6 A S24  1 
HETATM 2782 H H101 . KY6 C 2 .   ? 1.15988   6.84463   25.75287  1.000 62.09238  ? 201 KY6 A H101 1 
HETATM 2783 H H121 . KY6 C 2 .   ? -0.80245  8.32020   25.65308  1.000 33.22311  ? 201 KY6 A H121 1 
HETATM 2784 H H171 . KY6 C 2 .   ? -4.23836  10.17810  23.42457  1.000 35.29776  ? 201 KY6 A H171 1 
HETATM 2785 H H181 . KY6 C 2 .   ? -5.45646  11.85104  24.47957  1.000 46.40654  ? 201 KY6 A H181 1 
HETATM 2786 H H013 . KY6 C 2 .   ? 2.45720   3.12383   19.67121  1.000 61.56374  ? 201 KY6 A H013 1 
HETATM 2787 H H012 . KY6 C 2 .   ? 3.07152   1.66998   19.75031  1.000 61.56374  ? 201 KY6 A H012 1 
HETATM 2788 H H011 . KY6 C 2 .   ? 1.70463   1.97882   20.47359  1.000 61.56374  ? 201 KY6 A H011 1 
HETATM 2789 H H032 . KY6 C 2 .   ? 4.97177   1.77557   20.89284  1.000 56.56086  ? 201 KY6 A H032 1 
HETATM 2790 H H031 . KY6 C 2 .   ? 5.22188   2.67784   22.14263  1.000 56.56086  ? 201 KY6 A H031 1 
HETATM 2791 H H041 . KY6 C 2 .   ? 3.68942   0.23955   22.28942  1.000 57.63278  ? 201 KY6 A H041 1 
HETATM 2792 H H042 . KY6 C 2 .   ? 4.09754   1.10385   23.54517  1.000 57.63278  ? 201 KY6 A H042 1 
HETATM 2793 H H071 . KY6 C 2 .   ? 4.23407   3.65792   23.78469  1.000 64.30581  ? 201 KY6 A H071 1 
HETATM 2794 H H081 . KY6 C 2 .   ? 3.30310   5.22398   25.25364  1.000 60.72040  ? 201 KY6 A H081 1 
HETATM 2795 H H221 . KY6 C 2 .   ? -3.23256  11.36108  27.82413  1.000 49.02786  ? 201 KY6 A H221 1 
HETATM 2796 H H231 . KY6 C 2 .   ? -2.02046  9.68515   26.76613  1.000 59.03222  ? 201 KY6 A H231 1 
HETATM 2797 H H261 . KY6 C 2 .   ? 0.99839   4.07582   21.29639  1.000 47.39662  ? 201 KY6 A H261 1 
HETATM 2798 H H051 . KY6 C 2 .   ? 6.10043   -0.01599  22.09789  1.000 84.15011  ? 201 KY6 A H051 1 
HETATM 2799 C C10  . KY6 D 2 .   ? -8.49907  3.08913   -1.70422  1.000 52.49344  ? 201 KY6 B C10  1 
HETATM 2800 C C11  . KY6 D 2 .   ? -7.51890  3.43509   -0.81440  1.000 61.39063  ? 201 KY6 B C11  1 
HETATM 2801 C C12  . KY6 D 2 .   ? -6.52193  4.46308   -1.09456  1.000 47.05373  ? 201 KY6 B C12  1 
HETATM 2802 C C13  . KY6 D 2 .   ? -5.69477  5.16705   -0.27471  1.000 49.49103  ? 201 KY6 B C13  1 
HETATM 2803 C C14  . KY6 D 2 .   ? -5.75550  4.86502   1.12830   1.000 51.00041  ? 201 KY6 B C14  1 
HETATM 2804 C C16  . KY6 D 2 .   ? -4.70282  6.22104   -0.67187  1.000 49.30684  ? 201 KY6 B C16  1 
HETATM 2805 C C17  . KY6 D 2 .   ? -3.92263  6.90101   0.27299   1.000 47.70800  ? 201 KY6 B C17  1 
HETATM 2806 C C18  . KY6 D 2 .   ? -3.00569  7.87800   -0.09916  1.000 41.56462  ? 201 KY6 B C18  1 
HETATM 2807 C C19  . KY6 D 2 .   ? -2.82494  8.17803   -1.43719  1.000 45.57547  ? 201 KY6 B C19  1 
HETATM 2808 C C20  . KY6 D 2 .   ? -1.87600  9.19102   -1.82835  1.000 52.92110  ? 201 KY6 B C20  1 
HETATM 2809 C C01  . KY6 D 2 .   ? -11.30839 -1.24191  2.22522   1.000 61.60027  ? 201 KY6 B C01  1 
HETATM 2810 C C03  . KY6 D 2 .   ? -12.87877 -1.47684  0.28552   1.000 66.09472  ? 201 KY6 B C03  1 
HETATM 2811 C C04  . KY6 D 2 .   ? -12.51294 -2.76083  -0.48258  1.000 62.61313  ? 201 KY6 B C04  1 
HETATM 2812 C C06  . KY6 D 2 .   ? -10.93176 0.14813   0.16718   1.000 58.95229  ? 201 KY6 B C06  1 
HETATM 2813 C C07  . KY6 D 2 .   ? -11.27701 0.57016   -1.14674  1.000 55.96012  ? 201 KY6 B C07  1 
HETATM 2814 C C08  . KY6 D 2 .   ? -10.53212 1.52917   -1.81786  1.000 54.72402  ? 201 KY6 B C08  1 
HETATM 2815 C C09  . KY6 D 2 .   ? -9.40599  2.09513   -1.19007  1.000 63.12414  ? 201 KY6 B C09  1 
HETATM 2816 C C22  . KY6 D 2 .   ? -3.56113  7.50506   -2.40106  1.000 51.91453  ? 201 KY6 B C22  1 
HETATM 2817 C C23  . KY6 D 2 .   ? -4.47608  6.53707   -2.01791  1.000 60.00550  ? 201 KY6 B C23  1 
HETATM 2818 C C25  . KY6 D 2 .   ? -9.05875  1.68610   0.09986   1.000 60.35153  ? 201 KY6 B C25  1 
HETATM 2819 C C26  . KY6 D 2 .   ? -9.79164  0.73310   0.78898   1.000 47.42643  ? 201 KY6 B C26  1 
HETATM 2820 N N02  . KY6 D 2 .   ? -11.68965 -0.81187  0.85431   1.000 64.29002  ? 201 KY6 B N02  1 
HETATM 2821 N N15  . KY6 D 2 .   ? -5.78229  4.60800   2.24030   1.000 44.79680  ? 201 KY6 B N15  1 
HETATM 2822 N N21  . KY6 D 2 .   ? -1.15404  10.03002  -2.11847  1.000 58.30964  ? 201 KY6 B N21  1 
HETATM 2823 O O05  . KY6 D 2 .   ? -13.65902 -3.55280  -0.83038  1.000 65.56287  ? 201 KY6 B O05  1 
HETATM 2824 S S24  . KY6 D 2 .   ? -7.64363  2.50806   0.66161   1.000 47.03157  ? 201 KY6 B S24  1 
HETATM 2825 H H101 . KY6 D 2 .   ? -8.57623  3.46715   -2.57019  1.000 62.99213  ? 201 KY6 B H101 1 
HETATM 2826 H H121 . KY6 D 2 .   ? -6.45011  4.66010   -2.01157  1.000 56.46447  ? 201 KY6 B H121 1 
HETATM 2827 H H171 . KY6 D 2 .   ? -4.04146  6.72299   1.19501   1.000 57.24960  ? 201 KY6 B H171 1 
HETATM 2828 H H181 . KY6 D 2 .   ? -2.50055  8.34298   0.56275   1.000 49.87755  ? 201 KY6 B H181 1 
HETATM 2829 H H013 . KY6 D 2 .   ? -11.36926 -0.48592  2.83225   1.000 73.92032  ? 201 KY6 B H013 1 
HETATM 2830 H H012 . KY6 D 2 .   ? -11.89534 -1.94791  2.55132   1.000 73.92032  ? 201 KY6 B H012 1 
HETATM 2831 H H011 . KY6 D 2 .   ? -10.39840 -1.58193  2.22304   1.000 73.92032  ? 201 KY6 B H011 1 
HETATM 2832 H H032 . KY6 D 2 .   ? -13.50063 -1.70185  1.01263   1.000 79.31367  ? 201 KY6 B H032 1 
HETATM 2833 H H031 . KY6 D 2 .   ? -13.37387 -0.86082  -0.29437  1.000 79.31367  ? 201 KY6 B H031 1 
HETATM 2834 H H041 . KY6 D 2 .   ? -11.91584 -3.31585  0.06829   1.000 75.13576  ? 201 KY6 B H041 1 
HETATM 2835 H H042 . KY6 D 2 .   ? -12.01209 -2.53782  -1.30167  1.000 75.13576  ? 201 KY6 B H042 1 
HETATM 2836 H H071 . KY6 D 2 .   ? -12.02910 0.19619   -1.57361  1.000 67.15214  ? 201 KY6 B H071 1 
HETATM 2837 H H081 . KY6 D 2 .   ? -10.76329 1.80719   -2.70081  1.000 65.66883  ? 201 KY6 B H081 1 
HETATM 2838 H H221 . KY6 D 2 .   ? -3.43731  7.71208   -3.32408  1.000 62.29744  ? 201 KY6 B H221 1 
HETATM 2839 H H231 . KY6 D 2 .   ? -4.97721  6.09009   -2.68582  1.000 72.00660  ? 201 KY6 B H231 1 
HETATM 2840 H H261 . KY6 D 2 .   ? -9.51647  0.49207   1.65392   1.000 56.91172  ? 201 KY6 B H261 1 
HETATM 2841 H H051 . KY6 D 2 .   ? -14.39803 -3.13079  -0.94623  1.000 78.67544  ? 201 KY6 B H051 1 
HETATM 2842 O O    . HOH E 3 .   ? 5.01900   5.87200   13.62000  1.000 48.33832  ? 301 HOH A O    1 
HETATM 2843 O O    . HOH E 3 .   ? -8.15400  10.76800  12.57600  1.000 67.68252  ? 302 HOH A O    1 
HETATM 2844 O O    . HOH E 3 .   ? -20.848   32.179    27.395    1.000 78.45226  ? 303 HOH A O    1 
HETATM 2845 O O    . HOH E 3 .   ? 2.63500   20.14500  29.06600  1.000 64.91619  ? 304 HOH A O    1 
HETATM 2846 O O    . HOH E 3 .   ? 21.116    9.250     22.373    1.000 80.19400  ? 305 HOH A O    1 
HETATM 2847 O O    . HOH E 3 .   ? 10.04700  14.63100  23.84300  1.000 63.19113  ? 306 HOH A O    1 
HETATM 2848 O O    . HOH E 3 .   ? -6.33100  16.21600  27.06200  1.000 46.34835  ? 307 HOH A O    1 
HETATM 2849 O O    . HOH E 3 .   ? 1.34000   15.16700  16.06500  1.000 63.42936  ? 308 HOH A O    1 
HETATM 2850 O O    . HOH E 3 .   ? -11.28600 9.74600   13.47600  1.000 81.01655  ? 309 HOH A O    1 
HETATM 2851 O O    . HOH E 3 .   ? 3.92600   -0.00400  26.48200  1.000 59.33722  ? 310 HOH A O    1 
HETATM 2852 O O    . HOH E 3 .   ? -7.76100  15.51100  36.64500  1.000 41.49682  ? 311 HOH A O    1 
HETATM 2853 O O    . HOH E 3 .   ? -3.40300  19.49200  33.84700  1.000 64.77725  ? 312 HOH A O    1 
HETATM 2854 O O    . HOH E 3 .   ? -3.71700  20.03500  16.01400  1.000 44.84871  ? 313 HOH A O    1 
HETATM 2855 O O    . HOH E 3 .   ? 4.39100   7.97000   12.61600  1.000 60.70273  ? 314 HOH A O    1 
HETATM 2856 O O    . HOH E 3 .   ? -22.86100 18.38300  28.61900  1.000 64.58567  ? 315 HOH A O    1 
HETATM 2857 O O    . HOH E 3 .   ? -10.56700 8.71800   35.29500  1.000 66.20444  ? 316 HOH A O    1 
HETATM 2858 O O    . HOH E 3 .   ? -8.23500  2.41200   18.97800  1.000 67.59361  ? 317 HOH A O    1 
HETATM 2859 O O    . HOH E 3 .   ? -7.79900  -2.99400  22.66100  1.000 79.18992  ? 318 HOH A O    1 
HETATM 2860 O O    . HOH E 3 .   ? 4.41700   -8.66100  32.22500  1.000 82.58313  ? 319 HOH A O    1 
HETATM 2861 O O    . HOH E 3 .   ? -5.370    19.311    35.962    1.000 69.44635  ? 320 HOH A O    1 
HETATM 2862 O O    . HOH E 3 .   ? -6.20500  13.40300  12.49000  1.000 69.97353  ? 321 HOH A O    1 
HETATM 2863 O O    . HOH E 3 .   ? -2.36900  1.07100   9.51200   1.000 65.99333  ? 322 HOH A O    1 
HETATM 2864 O O    . HOH F 3 .   ? 9.47000   26.07200  9.99900   1.000 77.82008  ? 301 HOH B O    1 
HETATM 2865 O O    . HOH F 3 .   ? -2.13100  24.11800  1.36900   1.000 48.68713  ? 302 HOH B O    1 
HETATM 2866 O O    . HOH F 3 .   ? -2.34800  24.78200  -1.44700  1.000 59.30223  ? 303 HOH B O    1 
HETATM 2867 O O    . HOH F 3 .   ? -6.46800  17.04400  7.18400   1.000 47.89410  ? 304 HOH B O    1 
HETATM 2868 O O    . HOH F 3 .   ? -5.81200  11.31100  10.80200  1.000 48.07383  ? 305 HOH B O    1 
HETATM 2869 O O    . HOH F 3 .   ? -1.951    20.199    -12.138   1.000 57.97081  ? 306 HOH B O    1 
HETATM 2870 O O    . HOH F 3 .   ? -10.89600 -3.62500  -4.02800  1.000 60.74604  ? 307 HOH B O    1 
HETATM 2871 O O    . HOH F 3 .   ? 21.92300  20.84900  6.05000   1.000 78.02792  ? 308 HOH B O    1 
HETATM 2872 O O    . HOH F 3 .   ? -1.67700  -0.54400  7.41800   1.000 72.56621  ? 309 HOH B O    1 
# 
