data_8W4W
# 
_entry.id   8W4W 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W4W         pdb_00008w4w 10.2210/pdb8w4w/pdb 
WWPDB D_1300039583 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W4W 
_pdbx_database_status.recvd_initial_deposition_date   2023-08-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              aquarius@mail.ecc.u-tokyo.ac.jp 
_pdbx_contact_author.name_first         Kiyohiko 
_pdbx_contact_author.name_last          Igarashi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5152-7177 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tachioka, M.'    1  0000-0002-3558-8700 
'Yamaguchi, S.'   2  ?                   
'Nakamura, A.'    3  ?                   
'Ishida, T.'      4  ?                   
'Kusaka, K.'      5  ?                   
'Yamada, T.'      6  ?                   
'Yano, N.'        7  ?                   
'Chatake, T.'     8  ?                   
'Tamada, T.'      9  ?                   
'Takeda, K.'      10 ?                   
'Niwa, S.'        11 ?                   
'Tanaka, H.'      12 ?                   
'Takahashi, S.'   13 ?                   
'Inaka, K.'       14 ?                   
'Furubayashi, N.' 15 ?                   
'Deguchi, S.'     16 ?                   
'Samejima, M.'    17 ?                   
'Igarashi, K.'    18 0000-0001-5152-7177 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Deprotonated Arginine Controls a Putative Catalytic Base in Invert-ing Family 6 Glycoside Hydrolase' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tachioka, M.'    1  0000-0002-3558-8700 
primary 'Yamaguchi, S.'   2  ?                   
primary 'Nakamura, A.'    3  ?                   
primary 'Ishida, T.'      4  ?                   
primary 'Kusaka, K.'      5  ?                   
primary 'Yamada, T.'      6  ?                   
primary 'Yano, N.'        7  ?                   
primary 'Chatake, T.'     8  ?                   
primary 'Tamada, T.'      9  ?                   
primary 'Takeda, K.'      10 ?                   
primary 'Niwa, S.'        11 ?                   
primary 'Tanaka, H.'      12 ?                   
primary 'Takahashi, S.'   13 ?                   
primary 'Inaka, K.'       14 ?                   
primary 'Furubayashi, N.' 15 ?                   
primary 'Deguchi, S.'     16 ?                   
primary 'Samejima, M.'    17 ?                   
primary 'Igarashi, K.'    18 0000-0001-5152-7177 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Glucanase 38381.574 1   ? ? ? ? 
2 water   nat water     18.015    250 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLACV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGECDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLACV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGECDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   ALA n 
1 3   ASN n 
1 4   ASN n 
1 5   PRO n 
1 6   TRP n 
1 7   THR n 
1 8   GLY n 
1 9   PHE n 
1 10  GLN n 
1 11  ILE n 
1 12  PHE n 
1 13  LEU n 
1 14  SER n 
1 15  PRO n 
1 16  TYR n 
1 17  TYR n 
1 18  ALA n 
1 19  ASN n 
1 20  GLU n 
1 21  VAL n 
1 22  ALA n 
1 23  ALA n 
1 24  ALA n 
1 25  ALA n 
1 26  LYS n 
1 27  GLN n 
1 28  ILE n 
1 29  THR n 
1 30  ASP n 
1 31  PRO n 
1 32  THR n 
1 33  LEU n 
1 34  SER n 
1 35  SER n 
1 36  LYS n 
1 37  ALA n 
1 38  ALA n 
1 39  SER n 
1 40  VAL n 
1 41  ALA n 
1 42  ASN n 
1 43  ILE n 
1 44  PRO n 
1 45  THR n 
1 46  PHE n 
1 47  THR n 
1 48  TRP n 
1 49  LEU n 
1 50  ASP n 
1 51  SER n 
1 52  VAL n 
1 53  ALA n 
1 54  LYS n 
1 55  ILE n 
1 56  PRO n 
1 57  ASP n 
1 58  LEU n 
1 59  GLY n 
1 60  THR n 
1 61  TYR n 
1 62  LEU n 
1 63  ALA n 
1 64  SER n 
1 65  ALA n 
1 66  SER n 
1 67  ALA n 
1 68  LEU n 
1 69  GLY n 
1 70  LYS n 
1 71  SER n 
1 72  THR n 
1 73  GLY n 
1 74  THR n 
1 75  LYS n 
1 76  GLN n 
1 77  LEU n 
1 78  VAL n 
1 79  GLN n 
1 80  ILE n 
1 81  VAL n 
1 82  ILE n 
1 83  TYR n 
1 84  ASP n 
1 85  LEU n 
1 86  PRO n 
1 87  ASP n 
1 88  ARG n 
1 89  ASP n 
1 90  CYS n 
1 91  ALA n 
1 92  ALA n 
1 93  LYS n 
1 94  ALA n 
1 95  SER n 
1 96  ASN n 
1 97  GLY n 
1 98  GLU n 
1 99  PHE n 
1 100 SER n 
1 101 ILE n 
1 102 ALA n 
1 103 ASN n 
1 104 ASN n 
1 105 GLY n 
1 106 GLN n 
1 107 ALA n 
1 108 ASN n 
1 109 TYR n 
1 110 GLU n 
1 111 ASN n 
1 112 TYR n 
1 113 ILE n 
1 114 ASP n 
1 115 GLN n 
1 116 ILE n 
1 117 VAL n 
1 118 ALA n 
1 119 GLN n 
1 120 ILE n 
1 121 GLN n 
1 122 GLN n 
1 123 PHE n 
1 124 PRO n 
1 125 ASP n 
1 126 VAL n 
1 127 ARG n 
1 128 VAL n 
1 129 VAL n 
1 130 ALA n 
1 131 VAL n 
1 132 ILE n 
1 133 GLU n 
1 134 PRO n 
1 135 ASP n 
1 136 SER n 
1 137 LEU n 
1 138 ALA n 
1 139 ASN n 
1 140 LEU n 
1 141 VAL n 
1 142 THR n 
1 143 ASN n 
1 144 LEU n 
1 145 ASN n 
1 146 VAL n 
1 147 GLN n 
1 148 LYS n 
1 149 CYS n 
1 150 ALA n 
1 151 ASN n 
1 152 ALA n 
1 153 LYS n 
1 154 THR n 
1 155 THR n 
1 156 TYR n 
1 157 LEU n 
1 158 ALA n 
1 159 CYS n 
1 160 VAL n 
1 161 ASN n 
1 162 TYR n 
1 163 ALA n 
1 164 LEU n 
1 165 THR n 
1 166 ASN n 
1 167 LEU n 
1 168 ALA n 
1 169 LYS n 
1 170 VAL n 
1 171 GLY n 
1 172 VAL n 
1 173 TYR n 
1 174 MET n 
1 175 TYR n 
1 176 MET n 
1 177 ASP n 
1 178 ALA n 
1 179 GLY n 
1 180 HIS n 
1 181 ALA n 
1 182 GLY n 
1 183 TRP n 
1 184 LEU n 
1 185 GLY n 
1 186 TRP n 
1 187 PRO n 
1 188 ALA n 
1 189 ASN n 
1 190 LEU n 
1 191 SER n 
1 192 PRO n 
1 193 ALA n 
1 194 ALA n 
1 195 GLN n 
1 196 LEU n 
1 197 PHE n 
1 198 THR n 
1 199 GLN n 
1 200 VAL n 
1 201 TRP n 
1 202 GLN n 
1 203 ASN n 
1 204 ALA n 
1 205 GLY n 
1 206 LYS n 
1 207 SER n 
1 208 PRO n 
1 209 PHE n 
1 210 ILE n 
1 211 LYS n 
1 212 GLY n 
1 213 LEU n 
1 214 ALA n 
1 215 THR n 
1 216 ASN n 
1 217 VAL n 
1 218 ALA n 
1 219 ASN n 
1 220 TYR n 
1 221 ASN n 
1 222 ALA n 
1 223 LEU n 
1 224 GLN n 
1 225 ALA n 
1 226 ALA n 
1 227 SER n 
1 228 PRO n 
1 229 ASP n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 GLN n 
1 234 GLY n 
1 235 ASN n 
1 236 PRO n 
1 237 ASN n 
1 238 TYR n 
1 239 ASP n 
1 240 GLU n 
1 241 ILE n 
1 242 HIS n 
1 243 TYR n 
1 244 ILE n 
1 245 ASN n 
1 246 ALA n 
1 247 LEU n 
1 248 ALA n 
1 249 PRO n 
1 250 LEU n 
1 251 LEU n 
1 252 GLN n 
1 253 GLN n 
1 254 ALA n 
1 255 GLY n 
1 256 TRP n 
1 257 ASP n 
1 258 ALA n 
1 259 THR n 
1 260 PHE n 
1 261 ILE n 
1 262 VAL n 
1 263 ASP n 
1 264 GLN n 
1 265 GLY n 
1 266 ARG n 
1 267 SER n 
1 268 GLY n 
1 269 VAL n 
1 270 GLN n 
1 271 ASN n 
1 272 ILE n 
1 273 ARG n 
1 274 GLN n 
1 275 GLN n 
1 276 TRP n 
1 277 GLY n 
1 278 ASP n 
1 279 TRP n 
1 280 CYS n 
1 281 ASN n 
1 282 ILE n 
1 283 LYS n 
1 284 GLY n 
1 285 ALA n 
1 286 GLY n 
1 287 PHE n 
1 288 GLY n 
1 289 THR n 
1 290 ARG n 
1 291 PRO n 
1 292 THR n 
1 293 THR n 
1 294 ASN n 
1 295 THR n 
1 296 GLY n 
1 297 SER n 
1 298 GLN n 
1 299 PHE n 
1 300 ILE n 
1 301 ASP n 
1 302 SER n 
1 303 ILE n 
1 304 VAL n 
1 305 TRP n 
1 306 VAL n 
1 307 LYS n 
1 308 PRO n 
1 309 GLY n 
1 310 GLY n 
1 311 GLU n 
1 312 CYS n 
1 313 ASP n 
1 314 GLY n 
1 315 THR n 
1 316 SER n 
1 317 ASN n 
1 318 SER n 
1 319 SER n 
1 320 SER n 
1 321 PRO n 
1 322 ARG n 
1 323 TYR n 
1 324 ASP n 
1 325 SER n 
1 326 THR n 
1 327 CYS n 
1 328 SER n 
1 329 LEU n 
1 330 PRO n 
1 331 ASP n 
1 332 ALA n 
1 333 ALA n 
1 334 GLN n 
1 335 PRO n 
1 336 ALA n 
1 337 PRO n 
1 338 GLU n 
1 339 ALA n 
1 340 GLY n 
1 341 THR n 
1 342 TRP n 
1 343 PHE n 
1 344 GLN n 
1 345 ALA n 
1 346 TYR n 
1 347 PHE n 
1 348 GLN n 
1 349 THR n 
1 350 LEU n 
1 351 VAL n 
1 352 SER n 
1 353 ALA n 
1 354 ALA n 
1 355 ASN n 
1 356 PRO n 
1 357 PRO n 
1 358 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   358 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 cel6A 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    K-3 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Phanerodontia chrysosporium' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2822231 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Komagataella pastoris' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     4922 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   82  82  SER SER A . n 
A 1 2   ALA 2   83  83  ALA ALA A . n 
A 1 3   ASN 3   84  84  ASN ASN A . n 
A 1 4   ASN 4   85  85  ASN ASN A . n 
A 1 5   PRO 5   86  86  PRO PRO A . n 
A 1 6   TRP 6   87  87  TRP TRP A . n 
A 1 7   THR 7   88  88  THR THR A . n 
A 1 8   GLY 8   89  89  GLY GLY A . n 
A 1 9   PHE 9   90  90  PHE PHE A . n 
A 1 10  GLN 10  91  91  GLN GLN A . n 
A 1 11  ILE 11  92  92  ILE ILE A . n 
A 1 12  PHE 12  93  93  PHE PHE A . n 
A 1 13  LEU 13  94  94  LEU LEU A . n 
A 1 14  SER 14  95  95  SER SER A . n 
A 1 15  PRO 15  96  96  PRO PRO A . n 
A 1 16  TYR 16  97  97  TYR TYR A . n 
A 1 17  TYR 17  98  98  TYR TYR A . n 
A 1 18  ALA 18  99  99  ALA ALA A . n 
A 1 19  ASN 19  100 100 ASN ASN A . n 
A 1 20  GLU 20  101 101 GLU GLU A . n 
A 1 21  VAL 21  102 102 VAL VAL A . n 
A 1 22  ALA 22  103 103 ALA ALA A . n 
A 1 23  ALA 23  104 104 ALA ALA A . n 
A 1 24  ALA 24  105 105 ALA ALA A . n 
A 1 25  ALA 25  106 106 ALA ALA A . n 
A 1 26  LYS 26  107 107 LYS LYS A . n 
A 1 27  GLN 27  108 108 GLN GLN A . n 
A 1 28  ILE 28  109 109 ILE ILE A . n 
A 1 29  THR 29  110 110 THR THR A . n 
A 1 30  ASP 30  111 111 ASP ASP A . n 
A 1 31  PRO 31  112 112 PRO PRO A . n 
A 1 32  THR 32  113 113 THR THR A . n 
A 1 33  LEU 33  114 114 LEU LEU A . n 
A 1 34  SER 34  115 115 SER SER A . n 
A 1 35  SER 35  116 116 SER SER A . n 
A 1 36  LYS 36  117 117 LYS LYS A . n 
A 1 37  ALA 37  118 118 ALA ALA A . n 
A 1 38  ALA 38  119 119 ALA ALA A . n 
A 1 39  SER 39  120 120 SER SER A . n 
A 1 40  VAL 40  121 121 VAL VAL A . n 
A 1 41  ALA 41  122 122 ALA ALA A . n 
A 1 42  ASN 42  123 123 ASN ASN A . n 
A 1 43  ILE 43  124 124 ILE ILE A . n 
A 1 44  PRO 44  125 125 PRO PRO A . n 
A 1 45  THR 45  126 126 THR THR A . n 
A 1 46  PHE 46  127 127 PHE PHE A . n 
A 1 47  THR 47  128 128 THR THR A . n 
A 1 48  TRP 48  129 129 TRP TRP A . n 
A 1 49  LEU 49  130 130 LEU LEU A . n 
A 1 50  ASP 50  131 131 ASP ASP A . n 
A 1 51  SER 51  132 132 SER SER A . n 
A 1 52  VAL 52  133 133 VAL VAL A . n 
A 1 53  ALA 53  134 134 ALA ALA A . n 
A 1 54  LYS 54  135 135 LYS LYS A . n 
A 1 55  ILE 55  136 136 ILE ILE A . n 
A 1 56  PRO 56  137 137 PRO PRO A . n 
A 1 57  ASP 57  138 138 ASP ASP A . n 
A 1 58  LEU 58  139 139 LEU LEU A . n 
A 1 59  GLY 59  140 140 GLY GLY A . n 
A 1 60  THR 60  141 141 THR THR A . n 
A 1 61  TYR 61  142 142 TYR TYR A . n 
A 1 62  LEU 62  143 143 LEU LEU A . n 
A 1 63  ALA 63  144 144 ALA ALA A . n 
A 1 64  SER 64  145 145 SER SER A . n 
A 1 65  ALA 65  146 146 ALA ALA A . n 
A 1 66  SER 66  147 147 SER SER A . n 
A 1 67  ALA 67  148 148 ALA ALA A . n 
A 1 68  LEU 68  149 149 LEU LEU A . n 
A 1 69  GLY 69  150 150 GLY GLY A . n 
A 1 70  LYS 70  151 151 LYS LYS A . n 
A 1 71  SER 71  152 152 SER SER A . n 
A 1 72  THR 72  153 153 THR THR A . n 
A 1 73  GLY 73  154 154 GLY GLY A . n 
A 1 74  THR 74  155 155 THR THR A . n 
A 1 75  LYS 75  156 156 LYS LYS A . n 
A 1 76  GLN 76  157 157 GLN GLN A . n 
A 1 77  LEU 77  158 158 LEU LEU A . n 
A 1 78  VAL 78  159 159 VAL VAL A . n 
A 1 79  GLN 79  160 160 GLN GLN A . n 
A 1 80  ILE 80  161 161 ILE ILE A . n 
A 1 81  VAL 81  162 162 VAL VAL A . n 
A 1 82  ILE 82  163 163 ILE ILE A . n 
A 1 83  TYR 83  164 164 TYR TYR A . n 
A 1 84  ASP 84  165 165 ASP ASP A . n 
A 1 85  LEU 85  166 166 LEU LEU A . n 
A 1 86  PRO 86  167 167 PRO PRO A . n 
A 1 87  ASP 87  168 168 ASP ASP A . n 
A 1 88  ARG 88  169 169 ARG ARG A . n 
A 1 89  ASP 89  170 170 ASP ASP A . n 
A 1 90  CYS 90  171 171 CYS CYS A . n 
A 1 91  ALA 91  172 172 ALA ALA A . n 
A 1 92  ALA 92  173 173 ALA ALA A . n 
A 1 93  LYS 93  174 174 LYS LYS A . n 
A 1 94  ALA 94  175 175 ALA ALA A . n 
A 1 95  SER 95  176 176 SER SER A . n 
A 1 96  ASN 96  177 177 ASN ASN A . n 
A 1 97  GLY 97  178 178 GLY GLY A . n 
A 1 98  GLU 98  179 179 GLU GLU A . n 
A 1 99  PHE 99  180 180 PHE PHE A . n 
A 1 100 SER 100 181 181 SER SER A . n 
A 1 101 ILE 101 182 182 ILE ILE A . n 
A 1 102 ALA 102 183 183 ALA ALA A . n 
A 1 103 ASN 103 184 184 ASN ASN A . n 
A 1 104 ASN 104 185 185 ASN ASN A . n 
A 1 105 GLY 105 186 186 GLY GLY A . n 
A 1 106 GLN 106 187 187 GLN GLN A . n 
A 1 107 ALA 107 188 188 ALA ALA A . n 
A 1 108 ASN 108 189 189 ASN ASN A . n 
A 1 109 TYR 109 190 190 TYR TYR A . n 
A 1 110 GLU 110 191 191 GLU GLU A . n 
A 1 111 ASN 111 192 192 ASN ASN A . n 
A 1 112 TYR 112 193 193 TYR TYR A . n 
A 1 113 ILE 113 194 194 ILE ILE A . n 
A 1 114 ASP 114 195 195 ASP ASP A . n 
A 1 115 GLN 115 196 196 GLN GLN A . n 
A 1 116 ILE 116 197 197 ILE ILE A . n 
A 1 117 VAL 117 198 198 VAL VAL A . n 
A 1 118 ALA 118 199 199 ALA ALA A . n 
A 1 119 GLN 119 200 200 GLN GLN A . n 
A 1 120 ILE 120 201 201 ILE ILE A . n 
A 1 121 GLN 121 202 202 GLN GLN A . n 
A 1 122 GLN 122 203 203 GLN GLN A . n 
A 1 123 PHE 123 204 204 PHE PHE A . n 
A 1 124 PRO 124 205 205 PRO PRO A . n 
A 1 125 ASP 125 206 206 ASP ASP A . n 
A 1 126 VAL 126 207 207 VAL VAL A . n 
A 1 127 ARG 127 208 208 ARG ARG A . n 
A 1 128 VAL 128 209 209 VAL VAL A . n 
A 1 129 VAL 129 210 210 VAL VAL A . n 
A 1 130 ALA 130 211 211 ALA ALA A . n 
A 1 131 VAL 131 212 212 VAL VAL A . n 
A 1 132 ILE 132 213 213 ILE ILE A . n 
A 1 133 GLU 133 214 214 GLU GLU A . n 
A 1 134 PRO 134 215 215 PRO PRO A . n 
A 1 135 ASP 135 216 216 ASP ASP A . n 
A 1 136 SER 136 217 217 SER SER A . n 
A 1 137 LEU 137 218 218 LEU LEU A . n 
A 1 138 ALA 138 219 219 ALA ALA A . n 
A 1 139 ASN 139 220 220 ASN ASN A . n 
A 1 140 LEU 140 221 221 LEU LEU A . n 
A 1 141 VAL 141 222 222 VAL VAL A . n 
A 1 142 THR 142 223 223 THR THR A . n 
A 1 143 ASN 143 224 224 ASN ASN A . n 
A 1 144 LEU 144 225 225 LEU LEU A . n 
A 1 145 ASN 145 226 226 ASN ASN A . n 
A 1 146 VAL 146 227 227 VAL VAL A . n 
A 1 147 GLN 147 228 228 GLN GLN A . n 
A 1 148 LYS 148 229 229 LYS LYS A . n 
A 1 149 CYS 149 230 230 CYS CYS A . n 
A 1 150 ALA 150 231 231 ALA ALA A . n 
A 1 151 ASN 151 232 232 ASN ASN A . n 
A 1 152 ALA 152 233 233 ALA ALA A . n 
A 1 153 LYS 153 234 234 LYS LYS A . n 
A 1 154 THR 154 235 235 THR THR A . n 
A 1 155 THR 155 236 236 THR THR A . n 
A 1 156 TYR 156 237 237 TYR TYR A . n 
A 1 157 LEU 157 238 238 LEU LEU A . n 
A 1 158 ALA 158 239 239 ALA ALA A . n 
A 1 159 CYS 159 240 240 CYS CYS A . n 
A 1 160 VAL 160 241 241 VAL VAL A . n 
A 1 161 ASN 161 242 242 ASN ASN A . n 
A 1 162 TYR 162 243 243 TYR TYR A . n 
A 1 163 ALA 163 244 244 ALA ALA A . n 
A 1 164 LEU 164 245 245 LEU LEU A . n 
A 1 165 THR 165 246 246 THR THR A . n 
A 1 166 ASN 166 247 247 ASN ASN A . n 
A 1 167 LEU 167 248 248 LEU LEU A . n 
A 1 168 ALA 168 249 249 ALA ALA A . n 
A 1 169 LYS 169 250 250 LYS LYS A . n 
A 1 170 VAL 170 251 251 VAL VAL A . n 
A 1 171 GLY 171 252 252 GLY GLY A . n 
A 1 172 VAL 172 253 253 VAL VAL A . n 
A 1 173 TYR 173 254 254 TYR TYR A . n 
A 1 174 MET 174 255 255 MET MET A . n 
A 1 175 TYR 175 256 256 TYR TYR A . n 
A 1 176 MET 176 257 257 MET MET A . n 
A 1 177 ASP 177 258 258 ASP ASP A . n 
A 1 178 ALA 178 259 259 ALA ALA A . n 
A 1 179 GLY 179 260 260 GLY GLY A . n 
A 1 180 HIS 180 261 261 HIS HIS A . n 
A 1 181 ALA 181 262 262 ALA ALA A . n 
A 1 182 GLY 182 263 263 GLY GLY A . n 
A 1 183 TRP 183 264 264 TRP TRP A . n 
A 1 184 LEU 184 265 265 LEU LEU A . n 
A 1 185 GLY 185 266 266 GLY GLY A . n 
A 1 186 TRP 186 267 267 TRP TRP A . n 
A 1 187 PRO 187 268 268 PRO PRO A . n 
A 1 188 ALA 188 269 269 ALA ALA A . n 
A 1 189 ASN 189 270 270 ASN ASN A . n 
A 1 190 LEU 190 271 271 LEU LEU A . n 
A 1 191 SER 191 272 272 SER SER A . n 
A 1 192 PRO 192 273 273 PRO PRO A . n 
A 1 193 ALA 193 274 274 ALA ALA A . n 
A 1 194 ALA 194 275 275 ALA ALA A . n 
A 1 195 GLN 195 276 276 GLN GLN A . n 
A 1 196 LEU 196 277 277 LEU LEU A . n 
A 1 197 PHE 197 278 278 PHE PHE A . n 
A 1 198 THR 198 279 279 THR THR A . n 
A 1 199 GLN 199 280 280 GLN GLN A . n 
A 1 200 VAL 200 281 281 VAL VAL A . n 
A 1 201 TRP 201 282 282 TRP TRP A . n 
A 1 202 GLN 202 283 283 GLN GLN A . n 
A 1 203 ASN 203 284 284 ASN ASN A . n 
A 1 204 ALA 204 285 285 ALA ALA A . n 
A 1 205 GLY 205 286 286 GLY GLY A . n 
A 1 206 LYS 206 287 287 LYS LYS A . n 
A 1 207 SER 207 288 288 SER SER A . n 
A 1 208 PRO 208 289 289 PRO PRO A . n 
A 1 209 PHE 209 290 290 PHE PHE A . n 
A 1 210 ILE 210 291 291 ILE ILE A . n 
A 1 211 LYS 211 292 292 LYS LYS A . n 
A 1 212 GLY 212 293 293 GLY GLY A . n 
A 1 213 LEU 213 294 294 LEU LEU A . n 
A 1 214 ALA 214 295 295 ALA ALA A . n 
A 1 215 THR 215 296 296 THR THR A . n 
A 1 216 ASN 216 297 297 ASN ASN A . n 
A 1 217 VAL 217 298 298 VAL VAL A . n 
A 1 218 ALA 218 299 299 ALA ALA A . n 
A 1 219 ASN 219 300 300 ASN ASN A . n 
A 1 220 TYR 220 301 301 TYR TYR A . n 
A 1 221 ASN 221 302 302 ASN ASN A . n 
A 1 222 ALA 222 303 303 ALA ALA A . n 
A 1 223 LEU 223 304 304 LEU LEU A . n 
A 1 224 GLN 224 305 305 GLN GLN A . n 
A 1 225 ALA 225 306 306 ALA ALA A . n 
A 1 226 ALA 226 307 307 ALA ALA A . n 
A 1 227 SER 227 308 308 SER SER A . n 
A 1 228 PRO 228 309 309 PRO PRO A . n 
A 1 229 ASP 229 310 310 ASP ASP A . n 
A 1 230 PRO 230 311 311 PRO PRO A . n 
A 1 231 ILE 231 312 312 ILE ILE A . n 
A 1 232 THR 232 313 313 THR THR A . n 
A 1 233 GLN 233 314 314 GLN GLN A . n 
A 1 234 GLY 234 315 315 GLY GLY A . n 
A 1 235 ASN 235 316 316 ASN ASN A . n 
A 1 236 PRO 236 317 317 PRO PRO A . n 
A 1 237 ASN 237 318 318 ASN ASN A . n 
A 1 238 TYR 238 319 319 TYR TYR A . n 
A 1 239 ASP 239 320 320 ASP ASP A . n 
A 1 240 GLU 240 321 321 GLU GLU A . n 
A 1 241 ILE 241 322 322 ILE ILE A . n 
A 1 242 HIS 242 323 323 HIS HIS A . n 
A 1 243 TYR 243 324 324 TYR TYR A . n 
A 1 244 ILE 244 325 325 ILE ILE A . n 
A 1 245 ASN 245 326 326 ASN ASN A . n 
A 1 246 ALA 246 327 327 ALA ALA A . n 
A 1 247 LEU 247 328 328 LEU LEU A . n 
A 1 248 ALA 248 329 329 ALA ALA A . n 
A 1 249 PRO 249 330 330 PRO PRO A . n 
A 1 250 LEU 250 331 331 LEU LEU A . n 
A 1 251 LEU 251 332 332 LEU LEU A . n 
A 1 252 GLN 252 333 333 GLN GLN A . n 
A 1 253 GLN 253 334 334 GLN GLN A . n 
A 1 254 ALA 254 335 335 ALA ALA A . n 
A 1 255 GLY 255 336 336 GLY GLY A . n 
A 1 256 TRP 256 337 337 TRP TRP A . n 
A 1 257 ASP 257 338 338 ASP ASP A . n 
A 1 258 ALA 258 339 339 ALA ALA A . n 
A 1 259 THR 259 340 340 THR THR A . n 
A 1 260 PHE 260 341 341 PHE PHE A . n 
A 1 261 ILE 261 342 342 ILE ILE A . n 
A 1 262 VAL 262 343 343 VAL VAL A . n 
A 1 263 ASP 263 344 344 ASP ASP A . n 
A 1 264 GLN 264 345 345 GLN GLN A . n 
A 1 265 GLY 265 346 346 GLY GLY A . n 
A 1 266 ARG 266 347 347 ARG ARG A . n 
A 1 267 SER 267 348 348 SER SER A . n 
A 1 268 GLY 268 349 349 GLY GLY A . n 
A 1 269 VAL 269 350 350 VAL VAL A . n 
A 1 270 GLN 270 351 351 GLN GLN A . n 
A 1 271 ASN 271 352 352 ASN ASN A . n 
A 1 272 ILE 272 353 353 ILE ILE A . n 
A 1 273 ARG 273 354 354 ARG ARG A . n 
A 1 274 GLN 274 355 355 GLN GLN A . n 
A 1 275 GLN 275 356 356 GLN GLN A . n 
A 1 276 TRP 276 357 357 TRP TRP A . n 
A 1 277 GLY 277 358 358 GLY GLY A . n 
A 1 278 ASP 278 359 359 ASP ASP A . n 
A 1 279 TRP 279 360 360 TRP TRP A . n 
A 1 280 CYS 280 361 361 CYS CYS A . n 
A 1 281 ASN 281 362 362 ASN ASN A . n 
A 1 282 ILE 282 363 363 ILE ILE A . n 
A 1 283 LYS 283 364 364 LYS LYS A . n 
A 1 284 GLY 284 365 365 GLY GLY A . n 
A 1 285 ALA 285 366 366 ALA ALA A . n 
A 1 286 GLY 286 367 367 GLY GLY A . n 
A 1 287 PHE 287 368 368 PHE PHE A . n 
A 1 288 GLY 288 369 369 GLY GLY A . n 
A 1 289 THR 289 370 370 THR THR A . n 
A 1 290 ARG 290 371 371 ARG ARG A . n 
A 1 291 PRO 291 372 372 PRO PRO A . n 
A 1 292 THR 292 373 373 THR THR A . n 
A 1 293 THR 293 374 374 THR THR A . n 
A 1 294 ASN 294 375 375 ASN ASN A . n 
A 1 295 THR 295 376 376 THR THR A . n 
A 1 296 GLY 296 377 377 GLY GLY A . n 
A 1 297 SER 297 378 378 SER SER A . n 
A 1 298 GLN 298 379 379 GLN GLN A . n 
A 1 299 PHE 299 380 380 PHE PHE A . n 
A 1 300 ILE 300 381 381 ILE ILE A . n 
A 1 301 ASP 301 382 382 ASP ASP A . n 
A 1 302 SER 302 383 383 SER SER A . n 
A 1 303 ILE 303 384 384 ILE ILE A . n 
A 1 304 VAL 304 385 385 VAL VAL A . n 
A 1 305 TRP 305 386 386 TRP TRP A . n 
A 1 306 VAL 306 387 387 VAL VAL A . n 
A 1 307 LYS 307 388 388 LYS LYS A . n 
A 1 308 PRO 308 389 389 PRO PRO A . n 
A 1 309 GLY 309 390 390 GLY GLY A . n 
A 1 310 GLY 310 391 391 GLY GLY A . n 
A 1 311 GLU 311 392 392 GLU GLU A . n 
A 1 312 CYS 312 393 393 CYS CYS A . n 
A 1 313 ASP 313 394 394 ASP ASP A . n 
A 1 314 GLY 314 395 395 GLY GLY A . n 
A 1 315 THR 315 396 396 THR THR A . n 
A 1 316 SER 316 397 397 SER SER A . n 
A 1 317 ASN 317 398 398 ASN ASN A . n 
A 1 318 SER 318 399 399 SER SER A . n 
A 1 319 SER 319 400 400 SER SER A . n 
A 1 320 SER 320 401 401 SER SER A . n 
A 1 321 PRO 321 402 402 PRO PRO A . n 
A 1 322 ARG 322 403 403 ARG ARG A . n 
A 1 323 TYR 323 404 404 TYR TYR A . n 
A 1 324 ASP 324 405 405 ASP ASP A . n 
A 1 325 SER 325 406 406 SER SER A . n 
A 1 326 THR 326 407 407 THR THR A . n 
A 1 327 CYS 327 408 408 CYS CYS A . n 
A 1 328 SER 328 409 409 SER SER A . n 
A 1 329 LEU 329 410 410 LEU LEU A . n 
A 1 330 PRO 330 411 411 PRO PRO A . n 
A 1 331 ASP 331 412 412 ASP ASP A . n 
A 1 332 ALA 332 413 413 ALA ALA A . n 
A 1 333 ALA 333 414 414 ALA ALA A . n 
A 1 334 GLN 334 415 415 GLN GLN A . n 
A 1 335 PRO 335 416 416 PRO PRO A . n 
A 1 336 ALA 336 417 417 ALA ALA A . n 
A 1 337 PRO 337 418 418 PRO PRO A . n 
A 1 338 GLU 338 419 419 GLU GLU A . n 
A 1 339 ALA 339 420 420 ALA ALA A . n 
A 1 340 GLY 340 421 421 GLY GLY A . n 
A 1 341 THR 341 422 422 THR THR A . n 
A 1 342 TRP 342 423 423 TRP TRP A . n 
A 1 343 PHE 343 424 424 PHE PHE A . n 
A 1 344 GLN 344 425 425 GLN GLN A . n 
A 1 345 ALA 345 426 426 ALA ALA A . n 
A 1 346 TYR 346 427 427 TYR TYR A . n 
A 1 347 PHE 347 428 428 PHE PHE A . n 
A 1 348 GLN 348 429 429 GLN GLN A . n 
A 1 349 THR 349 430 430 THR THR A . n 
A 1 350 LEU 350 431 431 LEU LEU A . n 
A 1 351 VAL 351 432 432 VAL VAL A . n 
A 1 352 SER 352 433 433 SER SER A . n 
A 1 353 ALA 353 434 434 ALA ALA A . n 
A 1 354 ALA 354 435 435 ALA ALA A . n 
A 1 355 ASN 355 436 436 ASN ASN A . n 
A 1 356 PRO 356 437 437 PRO PRO A . n 
A 1 357 PRO 357 438 438 PRO PRO A . n 
A 1 358 LEU 358 439 439 LEU LEU A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   501 244 HOH HOH A . 
B 2 HOH 2   502 110 HOH HOH A . 
B 2 HOH 3   503 169 HOH HOH A . 
B 2 HOH 4   504 234 HOH HOH A . 
B 2 HOH 5   505 248 HOH HOH A . 
B 2 HOH 6   506 105 HOH HOH A . 
B 2 HOH 7   507 199 HOH HOH A . 
B 2 HOH 8   508 227 HOH HOH A . 
B 2 HOH 9   509 196 HOH HOH A . 
B 2 HOH 10  510 151 HOH HOH A . 
B 2 HOH 11  511 100 HOH HOH A . 
B 2 HOH 12  512 170 HOH HOH A . 
B 2 HOH 13  513 82  HOH HOH A . 
B 2 HOH 14  514 129 HOH HOH A . 
B 2 HOH 15  515 162 HOH HOH A . 
B 2 HOH 16  516 68  HOH HOH A . 
B 2 HOH 17  517 183 HOH HOH A . 
B 2 HOH 18  518 149 HOH HOH A . 
B 2 HOH 19  519 112 HOH HOH A . 
B 2 HOH 20  520 146 HOH HOH A . 
B 2 HOH 21  521 243 HOH HOH A . 
B 2 HOH 22  522 91  HOH HOH A . 
B 2 HOH 23  523 86  HOH HOH A . 
B 2 HOH 24  524 241 HOH HOH A . 
B 2 HOH 25  525 240 HOH HOH A . 
B 2 HOH 26  526 125 HOH HOH A . 
B 2 HOH 27  527 114 HOH HOH A . 
B 2 HOH 28  528 187 HOH HOH A . 
B 2 HOH 29  529 218 HOH HOH A . 
B 2 HOH 30  530 127 HOH HOH A . 
B 2 HOH 31  531 144 HOH HOH A . 
B 2 HOH 32  532 133 HOH HOH A . 
B 2 HOH 33  533 171 HOH HOH A . 
B 2 HOH 34  534 128 HOH HOH A . 
B 2 HOH 35  535 184 HOH HOH A . 
B 2 HOH 36  536 14  HOH HOH A . 
B 2 HOH 37  537 74  HOH HOH A . 
B 2 HOH 38  538 89  HOH HOH A . 
B 2 HOH 39  539 117 HOH HOH A . 
B 2 HOH 40  540 179 HOH HOH A . 
B 2 HOH 41  541 236 HOH HOH A . 
B 2 HOH 42  542 103 HOH HOH A . 
B 2 HOH 43  543 26  HOH HOH A . 
B 2 HOH 44  544 214 HOH HOH A . 
B 2 HOH 45  545 208 HOH HOH A . 
B 2 HOH 46  546 203 HOH HOH A . 
B 2 HOH 47  547 167 HOH HOH A . 
B 2 HOH 48  548 131 HOH HOH A . 
B 2 HOH 49  549 8   HOH HOH A . 
B 2 HOH 50  550 22  HOH HOH A . 
B 2 HOH 51  551 191 HOH HOH A . 
B 2 HOH 52  552 40  HOH HOH A . 
B 2 HOH 53  553 207 HOH HOH A . 
B 2 HOH 54  554 212 HOH HOH A . 
B 2 HOH 55  555 73  HOH HOH A . 
B 2 HOH 56  556 173 HOH HOH A . 
B 2 HOH 57  557 21  HOH HOH A . 
B 2 HOH 58  558 7   HOH HOH A . 
B 2 HOH 59  559 190 HOH HOH A . 
B 2 HOH 60  560 108 HOH HOH A . 
B 2 HOH 61  561 46  HOH HOH A . 
B 2 HOH 62  562 226 HOH HOH A . 
B 2 HOH 63  563 223 HOH HOH A . 
B 2 HOH 64  564 4   HOH HOH A . 
B 2 HOH 65  565 33  HOH HOH A . 
B 2 HOH 66  566 60  HOH HOH A . 
B 2 HOH 67  567 52  HOH HOH A . 
B 2 HOH 68  568 20  HOH HOH A . 
B 2 HOH 69  569 56  HOH HOH A . 
B 2 HOH 70  570 2   HOH HOH A . 
B 2 HOH 71  571 16  HOH HOH A . 
B 2 HOH 72  572 182 HOH HOH A . 
B 2 HOH 73  573 186 HOH HOH A . 
B 2 HOH 74  574 70  HOH HOH A . 
B 2 HOH 75  575 66  HOH HOH A . 
B 2 HOH 76  576 102 HOH HOH A . 
B 2 HOH 77  577 222 HOH HOH A . 
B 2 HOH 78  578 47  HOH HOH A . 
B 2 HOH 79  579 63  HOH HOH A . 
B 2 HOH 80  580 137 HOH HOH A . 
B 2 HOH 81  581 78  HOH HOH A . 
B 2 HOH 82  582 163 HOH HOH A . 
B 2 HOH 83  583 62  HOH HOH A . 
B 2 HOH 84  584 83  HOH HOH A . 
B 2 HOH 85  585 27  HOH HOH A . 
B 2 HOH 86  586 201 HOH HOH A . 
B 2 HOH 87  587 93  HOH HOH A . 
B 2 HOH 88  588 119 HOH HOH A . 
B 2 HOH 89  589 43  HOH HOH A . 
B 2 HOH 90  590 140 HOH HOH A . 
B 2 HOH 91  591 12  HOH HOH A . 
B 2 HOH 92  592 9   HOH HOH A . 
B 2 HOH 93  593 28  HOH HOH A . 
B 2 HOH 94  594 181 HOH HOH A . 
B 2 HOH 95  595 19  HOH HOH A . 
B 2 HOH 96  596 109 HOH HOH A . 
B 2 HOH 97  597 174 HOH HOH A . 
B 2 HOH 98  598 115 HOH HOH A . 
B 2 HOH 99  599 198 HOH HOH A . 
B 2 HOH 100 600 77  HOH HOH A . 
B 2 HOH 101 601 220 HOH HOH A . 
B 2 HOH 102 602 55  HOH HOH A . 
B 2 HOH 103 603 29  HOH HOH A . 
B 2 HOH 104 604 48  HOH HOH A . 
B 2 HOH 105 605 143 HOH HOH A . 
B 2 HOH 106 606 97  HOH HOH A . 
B 2 HOH 107 607 24  HOH HOH A . 
B 2 HOH 108 608 54  HOH HOH A . 
B 2 HOH 109 609 158 HOH HOH A . 
B 2 HOH 110 610 126 HOH HOH A . 
B 2 HOH 111 611 17  HOH HOH A . 
B 2 HOH 112 612 168 HOH HOH A . 
B 2 HOH 113 613 57  HOH HOH A . 
B 2 HOH 114 614 23  HOH HOH A . 
B 2 HOH 115 615 161 HOH HOH A . 
B 2 HOH 116 616 81  HOH HOH A . 
B 2 HOH 117 617 1   HOH HOH A . 
B 2 HOH 118 618 165 HOH HOH A . 
B 2 HOH 119 619 85  HOH HOH A . 
B 2 HOH 120 620 30  HOH HOH A . 
B 2 HOH 121 621 15  HOH HOH A . 
B 2 HOH 122 622 58  HOH HOH A . 
B 2 HOH 123 623 229 HOH HOH A . 
B 2 HOH 124 624 154 HOH HOH A . 
B 2 HOH 125 625 120 HOH HOH A . 
B 2 HOH 126 626 42  HOH HOH A . 
B 2 HOH 127 627 142 HOH HOH A . 
B 2 HOH 128 628 32  HOH HOH A . 
B 2 HOH 129 629 113 HOH HOH A . 
B 2 HOH 130 630 134 HOH HOH A . 
B 2 HOH 131 631 61  HOH HOH A . 
B 2 HOH 132 632 136 HOH HOH A . 
B 2 HOH 133 633 38  HOH HOH A . 
B 2 HOH 134 634 59  HOH HOH A . 
B 2 HOH 135 635 36  HOH HOH A . 
B 2 HOH 136 636 95  HOH HOH A . 
B 2 HOH 137 637 107 HOH HOH A . 
B 2 HOH 138 638 31  HOH HOH A . 
B 2 HOH 139 639 156 HOH HOH A . 
B 2 HOH 140 640 18  HOH HOH A . 
B 2 HOH 141 641 11  HOH HOH A . 
B 2 HOH 142 642 49  HOH HOH A . 
B 2 HOH 143 643 10  HOH HOH A . 
B 2 HOH 144 644 6   HOH HOH A . 
B 2 HOH 145 645 5   HOH HOH A . 
B 2 HOH 146 646 99  HOH HOH A . 
B 2 HOH 147 647 177 HOH HOH A . 
B 2 HOH 148 648 164 HOH HOH A . 
B 2 HOH 149 649 145 HOH HOH A . 
B 2 HOH 150 650 139 HOH HOH A . 
B 2 HOH 151 651 124 HOH HOH A . 
B 2 HOH 152 652 67  HOH HOH A . 
B 2 HOH 153 653 3   HOH HOH A . 
B 2 HOH 154 654 53  HOH HOH A . 
B 2 HOH 155 655 206 HOH HOH A . 
B 2 HOH 156 656 247 HOH HOH A . 
B 2 HOH 157 657 147 HOH HOH A . 
B 2 HOH 158 658 35  HOH HOH A . 
B 2 HOH 159 659 94  HOH HOH A . 
B 2 HOH 160 660 44  HOH HOH A . 
B 2 HOH 161 661 210 HOH HOH A . 
B 2 HOH 162 662 221 HOH HOH A . 
B 2 HOH 163 663 101 HOH HOH A . 
B 2 HOH 164 664 25  HOH HOH A . 
B 2 HOH 165 665 192 HOH HOH A . 
B 2 HOH 166 666 90  HOH HOH A . 
B 2 HOH 167 667 150 HOH HOH A . 
B 2 HOH 168 668 88  HOH HOH A . 
B 2 HOH 169 669 189 HOH HOH A . 
B 2 HOH 170 670 176 HOH HOH A . 
B 2 HOH 171 671 34  HOH HOH A . 
B 2 HOH 172 672 132 HOH HOH A . 
B 2 HOH 173 673 69  HOH HOH A . 
B 2 HOH 174 674 155 HOH HOH A . 
B 2 HOH 175 675 228 HOH HOH A . 
B 2 HOH 176 676 205 HOH HOH A . 
B 2 HOH 177 677 104 HOH HOH A . 
B 2 HOH 178 678 213 HOH HOH A . 
B 2 HOH 179 679 75  HOH HOH A . 
B 2 HOH 180 680 65  HOH HOH A . 
B 2 HOH 181 681 98  HOH HOH A . 
B 2 HOH 182 682 51  HOH HOH A . 
B 2 HOH 183 683 71  HOH HOH A . 
B 2 HOH 184 684 41  HOH HOH A . 
B 2 HOH 185 685 13  HOH HOH A . 
B 2 HOH 186 686 141 HOH HOH A . 
B 2 HOH 187 687 96  HOH HOH A . 
B 2 HOH 188 688 116 HOH HOH A . 
B 2 HOH 189 689 106 HOH HOH A . 
B 2 HOH 190 690 72  HOH HOH A . 
B 2 HOH 191 691 84  HOH HOH A . 
B 2 HOH 192 692 194 HOH HOH A . 
B 2 HOH 193 693 216 HOH HOH A . 
B 2 HOH 194 694 87  HOH HOH A . 
B 2 HOH 195 695 231 HOH HOH A . 
B 2 HOH 196 696 202 HOH HOH A . 
B 2 HOH 197 697 45  HOH HOH A . 
B 2 HOH 198 698 148 HOH HOH A . 
B 2 HOH 199 699 37  HOH HOH A . 
B 2 HOH 200 700 80  HOH HOH A . 
B 2 HOH 201 701 79  HOH HOH A . 
B 2 HOH 202 702 246 HOH HOH A . 
B 2 HOH 203 703 157 HOH HOH A . 
B 2 HOH 204 704 225 HOH HOH A . 
B 2 HOH 205 705 118 HOH HOH A . 
B 2 HOH 206 706 215 HOH HOH A . 
B 2 HOH 207 707 233 HOH HOH A . 
B 2 HOH 208 708 39  HOH HOH A . 
B 2 HOH 209 709 237 HOH HOH A . 
B 2 HOH 210 710 159 HOH HOH A . 
B 2 HOH 211 711 166 HOH HOH A . 
B 2 HOH 212 712 64  HOH HOH A . 
B 2 HOH 213 713 76  HOH HOH A . 
B 2 HOH 214 714 152 HOH HOH A . 
B 2 HOH 215 715 175 HOH HOH A . 
B 2 HOH 216 716 138 HOH HOH A . 
B 2 HOH 217 717 121 HOH HOH A . 
B 2 HOH 218 718 50  HOH HOH A . 
B 2 HOH 219 719 111 HOH HOH A . 
B 2 HOH 220 720 188 HOH HOH A . 
B 2 HOH 221 721 160 HOH HOH A . 
B 2 HOH 222 722 172 HOH HOH A . 
B 2 HOH 223 723 249 HOH HOH A . 
B 2 HOH 224 724 232 HOH HOH A . 
B 2 HOH 225 725 153 HOH HOH A . 
B 2 HOH 226 726 92  HOH HOH A . 
B 2 HOH 227 727 122 HOH HOH A . 
B 2 HOH 228 728 135 HOH HOH A . 
B 2 HOH 229 729 123 HOH HOH A . 
B 2 HOH 230 730 217 HOH HOH A . 
B 2 HOH 231 731 130 HOH HOH A . 
B 2 HOH 232 732 185 HOH HOH A . 
B 2 HOH 233 733 219 HOH HOH A . 
B 2 HOH 234 734 200 HOH HOH A . 
B 2 HOH 235 735 245 HOH HOH A . 
B 2 HOH 236 736 211 HOH HOH A . 
B 2 HOH 237 737 242 HOH HOH A . 
B 2 HOH 238 738 239 HOH HOH A . 
B 2 HOH 239 739 238 HOH HOH A . 
B 2 HOH 240 740 224 HOH HOH A . 
B 2 HOH 241 741 195 HOH HOH A . 
B 2 HOH 242 742 209 HOH HOH A . 
B 2 HOH 243 743 250 HOH HOH A . 
B 2 HOH 244 744 197 HOH HOH A . 
B 2 HOH 245 745 230 HOH HOH A . 
B 2 HOH 246 746 204 HOH HOH A . 
B 2 HOH 247 747 180 HOH HOH A . 
B 2 HOH 248 748 178 HOH HOH A . 
B 2 HOH 249 749 235 HOH HOH A . 
B 2 HOH 250 750 193 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.dependencies 
_software.description 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.pdbx_ordinal 
_software.type 
_software.version 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX    ? ? 1 ? 1.19.2_4158 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? STARGazer ? ? 2 ? .           
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX    ? ? 3 ? 1.19.2_4158 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W4W 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     55.580 
_cell.length_a_esd                 ? 
_cell.length_b                     68.040 
_cell.length_b_esd                 ? 
_cell.length_c                     90.060 
_cell.length_c_esd                 ? 
_cell.volume                       340576.588 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W4W 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
loop_
_exptl.absorpt_coefficient_mu 
_exptl.absorpt_correction_T_max 
_exptl.absorpt_correction_T_min 
_exptl.absorpt_correction_type 
_exptl.absorpt_process_details 
_exptl.entry_id 
_exptl.crystals_number 
_exptl.details 
_exptl.method 
_exptl.method_details 
? ? ? ? ? 8W4W 1 ? 'X-RAY DIFFRACTION'   ? 
? ? ? ? ? 8W4W ? ? 'NEUTRON DIFFRACTION' ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.22 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          44.55 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'polyethylene glycol 3350, sodium chloride,2-methyl-2,4-pentandiol, acetate buffer' 
_exptl_crystal_grow.pdbx_pH_range   '5.2 - 5.7' 
_exptl_crystal_grow.temp            293 
# 
loop_
_diffrn.ambient_environment 
_diffrn.ambient_temp 
_diffrn.ambient_temp_details 
_diffrn.ambient_temp_esd 
_diffrn.crystal_id 
_diffrn.crystal_support 
_diffrn.crystal_treatment 
_diffrn.details 
_diffrn.id 
_diffrn.ambient_pressure 
_diffrn.ambient_pressure_esd 
_diffrn.ambient_pressure_gt 
_diffrn.ambient_pressure_lt 
_diffrn.ambient_temp_gt 
_diffrn.ambient_temp_lt 
_diffrn.pdbx_serial_crystal_experiment 
? 298 ? ? 1 ? ? ? 1 ? ? ? ? ? ? N 
? 298 ? ? 1 ? ? ? 2 ? ? ? ? ? ? N 
# 
loop_
_diffrn_detector.details 
_diffrn_detector.detector 
_diffrn_detector.diffrn_id 
_diffrn_detector.type 
_diffrn_detector.area_resol_mean 
_diffrn_detector.dtime 
_diffrn_detector.pdbx_frames_total 
_diffrn_detector.pdbx_collection_time_total 
_diffrn_detector.pdbx_collection_date 
_diffrn_detector.pdbx_frequency 
_diffrn_detector.id 
_diffrn_detector.number_of_axes 
? PIXEL          1 'DECTRIS PILATUS 6M' ? ? ? ? 2018-05-23 ? ? ? 
? DIFFRACTOMETER 2 iBIX                 ? ? ? ? 2018-04-27 ? ? ? 
# 
loop_
_diffrn_radiation.collimation 
_diffrn_radiation.diffrn_id 
_diffrn_radiation.filter_edge 
_diffrn_radiation.inhomogeneity 
_diffrn_radiation.monochromator 
_diffrn_radiation.polarisn_norm 
_diffrn_radiation.polarisn_ratio 
_diffrn_radiation.probe 
_diffrn_radiation.type 
_diffrn_radiation.xray_symbol 
_diffrn_radiation.wavelength_id 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l 
_diffrn_radiation.pdbx_wavelength_list 
_diffrn_radiation.pdbx_wavelength 
_diffrn_radiation.pdbx_diffrn_protocol 
_diffrn_radiation.pdbx_analyzer 
_diffrn_radiation.pdbx_scattering_type 
? 1 ? ? ? ? ? ? ? ? 1 M ? ? 'SINGLE WAVELENGTH' ? x-ray   
? 2 ? ? ? ? ? ? ? ? 2 L ? ? LAUE                ? neutron 
# 
loop_
_diffrn_radiation_wavelength.id 
_diffrn_radiation_wavelength.wavelength 
_diffrn_radiation_wavelength.wt 
1 1.0 1.0 
2 2.9 1.0 
3 5.6 1.0 
# 
loop_
_diffrn_source.current 
_diffrn_source.details 
_diffrn_source.diffrn_id 
_diffrn_source.power 
_diffrn_source.size 
_diffrn_source.source 
_diffrn_source.target 
_diffrn_source.type 
_diffrn_source.voltage 
_diffrn_source.take-off_angle 
_diffrn_source.pdbx_wavelength_list 
_diffrn_source.pdbx_wavelength 
_diffrn_source.pdbx_synchrotron_beamline 
_diffrn_source.pdbx_synchrotron_site 
? ? 1 ? ? SYNCHROTRON         ? 'PHOTON FACTORY BEAMLINE BL-5A' ? ? 1.0     ? BL-5A 'Photon Factory' 
? ? 2 ? ? 'SPALLATION SOURCE' ? 'J-PARC MLF BEAMLINE BL-03'     ? ? 2.9-5.6 ? BL-03 'JPARC MLF'      
# 
loop_
_reflns.B_iso_Wilson_estimate 
_reflns.entry_id 
_reflns.data_reduction_details 
_reflns.data_reduction_method 
_reflns.d_resolution_high 
_reflns.d_resolution_low 
_reflns.details 
_reflns.limit_h_max 
_reflns.limit_h_min 
_reflns.limit_k_max 
_reflns.limit_k_min 
_reflns.limit_l_max 
_reflns.limit_l_min 
_reflns.number_all 
_reflns.number_obs 
_reflns.observed_criterion 
_reflns.observed_criterion_F_max 
_reflns.observed_criterion_F_min 
_reflns.observed_criterion_I_max 
_reflns.observed_criterion_I_min 
_reflns.observed_criterion_sigma_F 
_reflns.observed_criterion_sigma_I 
_reflns.percent_possible_obs 
_reflns.R_free_details 
_reflns.Rmerge_F_all 
_reflns.Rmerge_F_obs 
_reflns.Friedel_coverage 
_reflns.number_gt 
_reflns.threshold_expression 
_reflns.pdbx_redundancy 
_reflns.pdbx_netI_over_av_sigmaI 
_reflns.pdbx_netI_over_sigmaI 
_reflns.pdbx_res_netI_over_av_sigmaI_2 
_reflns.pdbx_res_netI_over_sigmaI_2 
_reflns.pdbx_chi_squared 
_reflns.pdbx_scaling_rejects 
_reflns.pdbx_d_res_high_opt 
_reflns.pdbx_d_res_low_opt 
_reflns.pdbx_d_res_opt_method 
_reflns.phase_calculation_details 
_reflns.pdbx_Rrim_I_all 
_reflns.pdbx_Rpim_I_all 
_reflns.pdbx_d_opt 
_reflns.pdbx_number_measured_all 
_reflns.pdbx_diffrn_id 
_reflns.pdbx_ordinal 
_reflns.pdbx_CC_half 
_reflns.pdbx_CC_star 
_reflns.pdbx_R_split 
_reflns.pdbx_Rmerge_I_obs 
_reflns.pdbx_Rmerge_I_all 
_reflns.pdbx_Rsym_value 
_reflns.pdbx_CC_split_method 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1] 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2] 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3] 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1] 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2] 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3] 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1] 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2] 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3] 
_reflns.pdbx_aniso_diffraction_limit_1 
_reflns.pdbx_aniso_diffraction_limit_2 
_reflns.pdbx_aniso_diffraction_limit_3 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1] 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2] 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3] 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1] 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2] 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3] 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1] 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2] 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3] 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3 
_reflns.pdbx_orthogonalization_convention 
_reflns.pdbx_percent_possible_ellipsoidal 
_reflns.pdbx_percent_possible_spherical 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns.pdbx_percent_possible_spherical_anomalous 
_reflns.pdbx_redundancy_anomalous 
_reflns.pdbx_CC_half_anomalous 
_reflns.pdbx_absDiff_over_sigma_anomalous 
_reflns.pdbx_percent_possible_anomalous 
_reflns.pdbx_observed_signal_threshold 
_reflns.pdbx_signal_type 
_reflns.pdbx_signal_details 
_reflns.pdbx_signal_software_id 
13.85 8W4W ? ? 1.36 50.0 ? ? ? ? ? ? ? ? 70839 ? ? ? ? ? ? ? 95.6 ? ? ? ? ? ? 10.5 ? 32.2 ? ? ? ? ? ? ? ? ? ? ? ? 2 1 ? ? ? 0.066 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
13.85 8W4W ? ? 1.86 21.5 ? ? ? ? ? ? ? ? 27502 ? ? ? ? ? ? ? 94.2 ? ? ? ? ? ? 5.5  ? 4.9  ? ? ? ? ? ? ? ? ? ? ? ? 1 2 ? ? ? 0.336 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
1.36 1.38 ? ? ? ? ? ? 3095 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 2 ? ? ? ? ? 0.286 ? ? ? ? ? ? ? ? ? 
1.86 1.94 ? ? ? ? ? ? 2700 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 2 1 ? ? ? ? ? 0.677 ? ? ? ? ? ? ? ? ? 
# 
loop_
_refine.aniso_B[1][1] 
_refine.aniso_B[1][2] 
_refine.aniso_B[1][3] 
_refine.aniso_B[2][2] 
_refine.aniso_B[2][3] 
_refine.aniso_B[3][3] 
_refine.B_iso_max 
_refine.B_iso_mean 
_refine.B_iso_min 
_refine.correlation_coeff_Fo_to_Fc 
_refine.correlation_coeff_Fo_to_Fc_free 
_refine.details 
_refine.diff_density_max 
_refine.diff_density_max_esd 
_refine.diff_density_min 
_refine.diff_density_min_esd 
_refine.diff_density_rms 
_refine.diff_density_rms_esd 
_refine.entry_id 
_refine.pdbx_refine_id 
_refine.ls_abs_structure_details 
_refine.ls_abs_structure_Flack 
_refine.ls_abs_structure_Flack_esd 
_refine.ls_abs_structure_Rogers 
_refine.ls_abs_structure_Rogers_esd 
_refine.ls_d_res_high 
_refine.ls_d_res_low 
_refine.ls_extinction_coef 
_refine.ls_extinction_coef_esd 
_refine.ls_extinction_expression 
_refine.ls_extinction_method 
_refine.ls_goodness_of_fit_all 
_refine.ls_goodness_of_fit_all_esd 
_refine.ls_goodness_of_fit_obs 
_refine.ls_goodness_of_fit_obs_esd 
_refine.ls_hydrogen_treatment 
_refine.ls_matrix_type 
_refine.ls_number_constraints 
_refine.ls_number_parameters 
_refine.ls_number_reflns_all 
_refine.ls_number_reflns_obs 
_refine.ls_number_reflns_R_free 
_refine.ls_number_reflns_R_work 
_refine.ls_number_restraints 
_refine.ls_percent_reflns_obs 
_refine.ls_percent_reflns_R_free 
_refine.ls_R_factor_all 
_refine.ls_R_factor_obs 
_refine.ls_R_factor_R_free 
_refine.ls_R_factor_R_free_error 
_refine.ls_R_factor_R_free_error_details 
_refine.ls_R_factor_R_work 
_refine.ls_R_Fsqd_factor_obs 
_refine.ls_R_I_factor_obs 
_refine.ls_redundancy_reflns_all 
_refine.ls_redundancy_reflns_obs 
_refine.ls_restrained_S_all 
_refine.ls_restrained_S_obs 
_refine.ls_shift_over_esd_max 
_refine.ls_shift_over_esd_mean 
_refine.ls_structure_factor_coef 
_refine.ls_weighting_details 
_refine.ls_weighting_scheme 
_refine.ls_wR_factor_all 
_refine.ls_wR_factor_obs 
_refine.ls_wR_factor_R_free 
_refine.ls_wR_factor_R_work 
_refine.occupancy_max 
_refine.occupancy_min 
_refine.solvent_model_details 
_refine.solvent_model_param_bsol 
_refine.solvent_model_param_ksol 
_refine.pdbx_R_complete 
_refine.ls_R_factor_gt 
_refine.ls_goodness_of_fit_gt 
_refine.ls_goodness_of_fit_ref 
_refine.ls_shift_over_su_max 
_refine.ls_shift_over_su_max_lt 
_refine.ls_shift_over_su_mean 
_refine.ls_shift_over_su_mean_lt 
_refine.pdbx_ls_sigma_I 
_refine.pdbx_ls_sigma_F 
_refine.pdbx_ls_sigma_Fsqd 
_refine.pdbx_data_cutoff_high_absF 
_refine.pdbx_data_cutoff_high_rms_absF 
_refine.pdbx_data_cutoff_low_absF 
_refine.pdbx_isotropic_thermal_model 
_refine.pdbx_ls_cross_valid_method 
_refine.pdbx_method_to_determine_struct 
_refine.pdbx_starting_model 
_refine.pdbx_stereochemistry_target_values 
_refine.pdbx_R_Free_selection_details 
_refine.pdbx_stereochem_target_val_spec_case 
_refine.pdbx_overall_ESU_R 
_refine.pdbx_overall_ESU_R_Free 
_refine.pdbx_solvent_vdw_probe_radii 
_refine.pdbx_solvent_ion_probe_radii 
_refine.pdbx_solvent_shrinkage_radii 
_refine.pdbx_real_space_R 
_refine.pdbx_density_correlation 
_refine.pdbx_pd_number_of_powder_patterns 
_refine.pdbx_pd_number_of_points 
_refine.pdbx_pd_meas_number_of_points 
_refine.pdbx_pd_proc_ls_prof_R_factor 
_refine.pdbx_pd_proc_ls_prof_wR_factor 
_refine.pdbx_pd_Marquardt_correlation_coeff 
_refine.pdbx_pd_Fsqrd_R_factor 
_refine.pdbx_pd_ls_matrix_band_width 
_refine.pdbx_overall_phase_error 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI 
_refine.pdbx_overall_SU_R_free_Blow_DPI 
_refine.pdbx_overall_SU_R_Blow_DPI 
_refine.pdbx_TLS_residual_ADP_flag 
_refine.pdbx_diffrn_id 
_refine.overall_SU_B 
_refine.overall_SU_ML 
_refine.overall_SU_R_Cruickshank_DPI 
_refine.overall_SU_R_free 
_refine.overall_FOM_free_R_set 
_refine.overall_FOM_work_R_set 
_refine.pdbx_average_fsc_overall 
_refine.pdbx_average_fsc_work 
_refine.pdbx_average_fsc_free 
? ? ? ? ? ? ? 20.80 ? ? ? ? ? ? ? ? ? ? 8W4W 'X-RAY DIFFRACTION'   ? ? ? ? ? 1.36 34.99 ? ? ? ? ? ? ? ? ? ? ? ? ? 70782 3562 67220 
? 95.90 5.03 ? 0.1397 0.1561 ? ? 0.1389 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 'FLAT BULK SOLVENT MODEL' ? ? ? ? ? ? ? ? ? ? ? 1.39 ? ? 
? ? ? 'FREE R-VALUE' 'MOLECULAR REPLACEMENT' ? 'GeoStd + Monomer Library + CDL v1.2' ? ? ? ? 1.1100 ? 0.9000 ? ? ? ? ? ? ? ? ? ? 
15.7567 ? ? ? ? ? ? 0.1097 ? ? ? ? ? ? ? 
? ? ? ? ? ? ? ?     ? ? ? ? ? ? ? ? ? ? 8W4W 'NEUTRON DIFFRACTION' ? ? ? ? ? 1.86 21.5  ? ? ? ? ? ? ? ? ? ? ? ? ? 26666 ?    ?     
? 90.72 ?    ? ?      0.232  ? ? 0.209  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 'FLAT BULK SOLVENT MODEL' ? ? ? ? ? ? ? ? ? ? ? ?    ? ? 
? ? ? 'FREE R-VALUE' 'MOLECULAR REPLACEMENT' ? 'GeoStd + Monomer Library + CDL v1.2' ? ? ? ? 1.1100 ? 0.9000 ? ? ? ? ? ? ? ? ? ? 
15.7567 ? ? ? ? 1 ? 0.1097 ? ? ? ? ? ? ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2710 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.number_atoms_solvent             250 
_refine_hist.number_atoms_total               2960 
_refine_hist.d_res_high                       1.36 
_refine_hist.d_res_low                        34.99 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0111  ? 2955 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0401  ? 4078 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0829  ? 452  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0084  ? 604  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.3966 ? 1054 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.36 1.38  . . 130 2471 89.94 . . . . 0.2000 . . . . . . . . . . . 0.2224 
'X-RAY DIFFRACTION' 1.38 1.40  . . 138 2584 92.62 . . . . 0.1961 . . . . . . . . . . . 0.2069 
'X-RAY DIFFRACTION' 1.40 1.42  . . 126 2589 93.65 . . . . 0.1895 . . . . . . . . . . . 0.2000 
'X-RAY DIFFRACTION' 1.42 1.44  . . 148 2594 94.00 . . . . 0.1883 . . . . . . . . . . . 0.2222 
'X-RAY DIFFRACTION' 1.44 1.47  . . 144 2621 94.66 . . . . 0.1771 . . . . . . . . . . . 0.2045 
'X-RAY DIFFRACTION' 1.47 1.49  . . 151 2601 94.31 . . . . 0.1785 . . . . . . . . . . . 0.1946 
'X-RAY DIFFRACTION' 1.49 1.52  . . 119 2631 94.53 . . . . 0.1739 . . . . . . . . . . . 0.2183 
'X-RAY DIFFRACTION' 1.52 1.55  . . 151 2649 94.95 . . . . 0.1734 . . . . . . . . . . . 0.1970 
'X-RAY DIFFRACTION' 1.55 1.58  . . 151 2622 95.00 . . . . 0.1717 . . . . . . . . . . . 0.1962 
'X-RAY DIFFRACTION' 1.58 1.61  . . 138 2651 95.22 . . . . 0.1727 . . . . . . . . . . . 0.1762 
'X-RAY DIFFRACTION' 1.61 1.65  . . 148 2641 95.51 . . . . 0.1692 . . . . . . . . . . . 0.1937 
'X-RAY DIFFRACTION' 1.65 1.69  . . 126 2668 95.65 . . . . 0.1668 . . . . . . . . . . . 0.2070 
'X-RAY DIFFRACTION' 1.69 1.74  . . 118 2711 95.90 . . . . 0.1646 . . . . . . . . . . . 0.1896 
'X-RAY DIFFRACTION' 1.74 1.79  . . 140 2680 96.05 . . . . 0.1614 . . . . . . . . . . . 0.1745 
'X-RAY DIFFRACTION' 1.79 1.85  . . 169 2666 96.46 . . . . 0.1520 . . . . . . . . . . . 0.1811 
'X-RAY DIFFRACTION' 1.85 1.91  . . 154 2688 96.70 . . . . 0.1517 . . . . . . . . . . . 0.1778 
'X-RAY DIFFRACTION' 1.91 1.99  . . 148 2703 96.78 . . . . 0.1463 . . . . . . . . . . . 0.1681 
'X-RAY DIFFRACTION' 1.99 2.08  . . 135 2735 97.26 . . . . 0.1391 . . . . . . . . . . . 0.1637 
'X-RAY DIFFRACTION' 2.08 2.19  . . 146 2713 97.05 . . . . 0.1339 . . . . . . . . . . . 0.1624 
'X-RAY DIFFRACTION' 2.19 2.33  . . 143 2766 97.72 . . . . 0.1349 . . . . . . . . . . . 0.1359 
'X-RAY DIFFRACTION' 2.33 2.51  . . 134 2789 97.92 . . . . 0.1347 . . . . . . . . . . . 0.1429 
'X-RAY DIFFRACTION' 2.51 2.76  . . 149 2770 98.32 . . . . 0.1353 . . . . . . . . . . . 0.1489 
'X-RAY DIFFRACTION' 2.76 3.16  . . 142 2821 98.54 . . . . 0.1378 . . . . . . . . . . . 0.1622 
'X-RAY DIFFRACTION' 3.16 3.98  . . 156 2866 98.95 . . . . 0.1115 . . . . . . . . . . . 0.1267 
'X-RAY DIFFRACTION' 3.98 34.99 . . 158 2990 99.09 . . . . 0.1071 . . . . . . . . . . . 0.1173 
# 
_struct.entry_id                     8W4W 
_struct.title                        'Neutron structure of cellulase Cel6A from Phanerochaete chrysosporium at room temperature' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W4W 
_struct_keywords.text            'Cellulase, Glycoside hydrolase family 6, Cellobiohydrolase II, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    H3K419_PHACH 
_struct_ref.pdbx_db_accession          H3K419 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SANNPWTGFQIFLSPYYANEVAAAAKQITDPTLSSKAASVANIPTFTWLDSVAKIPDLGTYLASASALGKSTGTKQLVQI
VIYDLPDRDCAAKASNGEFSIANNGQANYENYIDQIVAQIQQFPDVRVVAVIEPDSLANLVTNLNVQKCANAKTTYLACV
NYALTNLAKVGVYMYMDAGHAGWLGWPANLSPAAQLFTQVWQNAGKSPFIKGLATNVANYNALQAASPDPITQGNPNYDE
IHYINALAPLLQQAGWDATFIVDQGRSGVQNIRQQWGDWCNIKGAGFGTRPTTNTGSQFIDSIVWVKPGGECDGTSNSSS
PRYDSTCSLPDAAQPAPEAGTWFQAYFQTLVSAANPPL
;
_struct_ref.pdbx_align_begin           82 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8W4W 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 358 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             H3K419 
_struct_ref_seq.db_align_beg                  82 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  439 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       82 
_struct_ref_seq.pdbx_auth_seq_align_end       439 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 0     ? 
1 MORE         0     ? 
1 'SSA (A^2)'  14240 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 14  ? GLN A 27  ? SER A 95  GLN A 108 1 ? 14 
HELX_P HELX_P2  AA2 ASP A 30  ? VAL A 40  ? ASP A 111 VAL A 121 1 ? 11 
HELX_P HELX_P3  AA3 ALA A 41  ? ILE A 43  ? ALA A 122 ILE A 124 5 ? 3  
HELX_P HELX_P4  AA4 SER A 51  ? ALA A 53  ? SER A 132 ALA A 134 5 ? 3  
HELX_P HELX_P5  AA5 LYS A 54  ? GLY A 73  ? LYS A 135 GLY A 154 1 ? 20 
HELX_P HELX_P6  AA6 ASN A 104 ? GLN A 121 ? ASN A 185 GLN A 202 1 ? 18 
HELX_P HELX_P7  AA7 ALA A 138 ? ASN A 143 ? ALA A 219 ASN A 224 1 ? 6  
HELX_P HELX_P8  AA8 VAL A 146 ? VAL A 170 ? VAL A 227 VAL A 251 1 ? 25 
HELX_P HELX_P9  AA9 TRP A 186 ? ALA A 188 ? TRP A 267 ALA A 269 5 ? 3  
HELX_P HELX_P10 AB1 ASN A 189 ? ALA A 204 ? ASN A 270 ALA A 285 1 ? 16 
HELX_P HELX_P11 AB2 ASP A 229 ? GLN A 233 ? ASP A 310 GLN A 314 5 ? 5  
HELX_P HELX_P12 AB3 ASP A 239 ? ALA A 254 ? ASP A 320 ALA A 335 1 ? 16 
HELX_P HELX_P13 AB4 ASP A 324 ? LEU A 329 ? ASP A 405 LEU A 410 5 ? 6  
HELX_P HELX_P14 AB5 PHE A 343 ? ALA A 353 ? PHE A 424 ALA A 434 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 90  SG A ? ? 1_555 A CYS 149 SG ? ? A CYS 171 A CYS 230 1_555 ? ? ? ? ? ? ? 2.040 ? ? 
disulf2 disulf ? ? A CYS 90  SG B ? ? 1_555 A CYS 149 SG ? ? A CYS 171 A CYS 230 1_555 ? ? ? ? ? ? ? 2.029 ? ? 
disulf3 disulf ? ? A CYS 280 SG ? ? ? 1_555 A CYS 327 SG A ? A CYS 361 A CYS 408 1_555 ? ? ? ? ? ? ? 2.045 ? ? 
disulf4 disulf ? ? A CYS 280 SG ? ? ? 1_555 A CYS 327 SG B ? A CYS 361 A CYS 408 1_555 ? ? ? ? ? ? ? 2.024 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 90  A CYS A 149 ? CYS A 171 ? 1_555 CYS A 230 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 90  B CYS A 149 ? CYS A 171 ? 1_555 CYS A 230 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 280 ? CYS A 327 A CYS A 361 ? 1_555 CYS A 408 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 280 ? CYS A 327 B CYS A 361 ? 1_555 CYS A 408 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLN 334 A . ? GLN 415 A PRO 335 A ? PRO 416 A 1 -7.06 
2 ASN 355 A . ? ASN 436 A PRO 356 A ? PRO 437 A 1 5.85  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA2 3 4 ? parallel 
AA2 4 5 ? parallel 
AA2 5 6 ? parallel 
AA2 6 7 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 10  ? ILE A 11  ? GLN A 91  ILE A 92  
AA1 2 GLN A 76  ? ILE A 82  ? GLN A 157 ILE A 163 
AA1 3 THR A 47  ? LEU A 49  ? THR A 128 LEU A 130 
AA2 1 GLN A 10  ? ILE A 11  ? GLN A 91  ILE A 92  
AA2 2 GLN A 76  ? ILE A 82  ? GLN A 157 ILE A 163 
AA2 3 ARG A 127 ? ILE A 132 ? ARG A 208 ILE A 213 
AA2 4 TYR A 173 ? ASP A 177 ? TYR A 254 ASP A 258 
AA2 5 ILE A 210 ? THR A 215 ? ILE A 291 THR A 296 
AA2 6 THR A 259 ? ASP A 263 ? THR A 340 ASP A 344 
AA2 7 ILE A 300 ? VAL A 304 ? ILE A 381 VAL A 385 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 10  ? N GLN A 91  O LEU A 77  ? O LEU A 158 
AA1 2 3 O VAL A 81  ? O VAL A 162 N LEU A 49  ? N LEU A 130 
AA2 1 2 N GLN A 10  ? N GLN A 91  O LEU A 77  ? O LEU A 158 
AA2 2 3 N VAL A 78  ? N VAL A 159 O ARG A 127 ? O ARG A 208 
AA2 3 4 N ALA A 130 ? N ALA A 211 O TYR A 173 ? O TYR A 254 
AA2 4 5 N MET A 176 ? N MET A 257 O GLY A 212 ? O GLY A 293 
AA2 5 6 N THR A 215 ? N THR A 296 O ILE A 261 ? O ILE A 342 
AA2 6 7 N VAL A 262 ? N VAL A 343 O VAL A 304 ? O VAL A 385 
# 
_pdbx_entry_details.entry_id                   8W4W 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 170 ? ? DD2 A ASP 216 ? ? 1.54 
2 1 OD2 A ASP 359 ? ? DD2 A ASP 412 ? ? 1.56 
3 1 NE2 A GLN 356 ? B O   A HOH 501 ? ? 2.03 
4 1 OE1 A GLN 429 ? ? O   A HOH 502 ? ? 2.12 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_1              165 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_2              165 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             OD2 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_3              165 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                112.38 
_pdbx_validate_rmsd_angle.angle_target_value         118.30 
_pdbx_validate_rmsd_angle.angle_deviation            -5.92 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.90 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 165 ? ? -149.13 33.31   
2 1 ASN A 184 ? ? -115.76 67.49   
3 1 ASN A 184 ? ? -116.04 67.83   
4 1 GLU A 214 ? ? 57.00   73.73   
5 1 SER A 217 ? ? -121.81 -85.59  
6 1 TRP A 264 ? ? -111.16 -70.52  
7 1 ASN A 300 ? ? -111.45 -163.63 
8 1 VAL A 387 ? ? -90.74  -61.76  
9 1 PRO A 418 ? ? -79.71  -169.71 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Ministry of Education, Culture, Sports, Science and Technology (Japan)' Japan 18H05494                                 1 
'Japan Society for the Promotion of Science (JSPS)'                      Japan '23H00341, 19H03013, 18J01906, 15J10657' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5XCY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W4W 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017992 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014697 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011104 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C   ? ? ? ? ? ? ? ? ? ? 6.64599990845  'Custom 0-Gaussian' ? 
D   ? ? ? ? ? ? ? ? ? ? 6.67100000381  'Custom 0-Gaussian' ? 
H   ? ? ? ? ? ? ? ? ? ? -3.73900008202 'Custom 0-Gaussian' ? 
N   ? ? ? ? ? ? ? ? ? ? 9.35999965668  'Custom 0-Gaussian' ? 
O   ? ? ? ? ? ? ? ? ? ? 5.8029999733   'Custom 0-Gaussian' ? 
O1- ? ? ? ? ? ? ? ? ? ? 5.8029999733   'Custom 0-Gaussian' ? 
S   ? ? ? ? ? ? ? ? ? ? 2.84699988365  'Custom 0-Gaussian' ? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? 27.30341  -25.60936 -23.91766 1.000 35.25958  ?  82  SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? 28.14400  -26.73356 -23.47057 1.000 52.00167  ?  82  SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? 27.27569  -27.94264 -23.12175 1.000 27.09487  ?  82  SER A C    1 
ATOM   4    O O    . SER A 1 1   ? 26.09688  -28.01619 -23.50914 1.000 37.24193  ?  82  SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? 29.05115  -26.35337 -22.28716 1.000 36.55172  ?  82  SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? 28.30643  -26.02452 -21.12679 1.000 48.84720  ?  82  SER A OG   1 
ATOM   7    H HA   . SER A 1 1   ? 28.81338  -27.00750 -24.28604 1.000 62.40200  ?  82  SER A HA   1 
ATOM   8    H HB2  . SER A 1 1   ? 29.69865  -27.19972 -22.05793 1.000 43.86206  ?  82  SER A HB2  1 
ATOM   9    H HB3  . SER A 1 1   ? 29.65270  -25.49016 -22.57192 1.000 43.86206  ?  82  SER A HB3  1 
ATOM   10   N N    . ALA A 1 2   ? 27.83912  -28.91649 -22.40057 1.000 21.39615  ?  83  ALA A N    1 
ATOM   11   C CA   . ALA A 1 2   ? 27.14242  -30.18694 -22.28772 1.000 19.43340  ?  83  ALA A CA   1 
ATOM   12   C C    A ALA A 1 2   ? 25.92142  -30.10118 -21.37838 0.480 17.25726  ?  83  ALA A C    1 
ATOM   13   C C    B ALA A 1 2   ? 25.92241  -30.10218 -21.37611 0.520 17.22841  ?  83  ALA A C    1 
ATOM   14   O O    . ALA A 1 2   ? 24.95054  -30.83496 -21.59344 1.000 20.79153  ?  83  ALA A O    1 
ATOM   15   C CB   A ALA A 1 2   ? 28.09959  -31.25000 -21.75052 0.480 20.15796  ?  83  ALA A CB   1 
ATOM   16   C CB   B ALA A 1 2   ? 28.10313  -31.25621 -21.77098 0.520 20.16196  ?  83  ALA A CB   1 
ATOM   17   H H    A ALA A 1 2   ? 28.73119  -28.85434 -21.90990 0.000 25.67538  ?  83  ALA A H    1 
ATOM   18   D D    B ALA A 1 2   ? 28.73091  -28.85672 -21.90910 1.000 25.67538  ?  83  ALA A D    1 
ATOM   19   H HA   A ALA A 1 2   ? 26.80157  -30.47780 -23.28136 0.480 23.32008  ?  83  ALA A HA   1 
ATOM   20   H HA   B ALA A 1 2   ? 26.79365  -30.47551 -23.27928 0.520 23.32008  ?  83  ALA A HA   1 
ATOM   21   H HB1  A ALA A 1 2   ? 28.06562  -31.24014 -20.66110 0.480 24.18956  ?  83  ALA A HB1  1 
ATOM   22   H HB1  B ALA A 1 2   ? 29.10700  -31.03697 -22.13469 0.520 24.19435  ?  83  ALA A HB1  1 
ATOM   23   H HB2  A ALA A 1 2   ? 27.79063  -32.22660 -22.12321 0.480 24.18956  ?  83  ALA A HB2  1 
ATOM   24   H HB2  B ALA A 1 2   ? 28.09224  -31.24624 -20.68108 0.520 24.19435  ?  83  ALA A HB2  1 
ATOM   25   H HB3  A ALA A 1 2   ? 29.10939  -31.02391 -22.09298 0.480 24.18956  ?  83  ALA A HB3  1 
ATOM   26   H HB3  B ALA A 1 2   ? 27.77972  -32.23064 -22.13703 0.520 24.19435  ?  83  ALA A HB3  1 
ATOM   27   N N    . ASN A 1 3   ? 25.95199  -29.24546 -20.35294 1.000 15.14308  ?  84  ASN A N    1 
ATOM   28   C CA   . ASN A 1 3   ? 24.89112  -29.13432 -19.36341 1.000 15.01640  ?  84  ASN A CA   1 
ATOM   29   C C    . ASN A 1 3   ? 24.12703  -27.85359 -19.65843 1.000 17.50756  ?  84  ASN A C    1 
ATOM   30   O O    . ASN A 1 3   ? 24.54514  -26.76840 -19.23066 1.000 23.29217  ?  84  ASN A O    1 
ATOM   31   C CB   . ASN A 1 3   ? 25.53038  -29.08011 -17.98329 1.000 17.96442  ?  84  ASN A CB   1 
ATOM   32   C CG   . ASN A 1 3   ? 24.53110  -28.91709 -16.87586 1.000 25.33632  ?  84  ASN A CG   1 
ATOM   33   O OD1  . ASN A 1 3   ? 23.41374  -29.38638 -17.00168 1.000 27.08888  ?  84  ASN A OD1  1 
ATOM   34   N ND2  . ASN A 1 3   ? 24.94989  -28.30019 -15.76126 1.000 21.61861  ?  84  ASN A ND2  1 
ATOM   35   H H    A ASN A 1 3   ? 26.72398  -28.60088 -20.18282 0.220 18.17169  ?  84  ASN A H    1 
ATOM   36   D D    B ASN A 1 3   ? 26.72436  -28.60044 -20.18621 0.780 18.17169  ?  84  ASN A D    1 
ATOM   37   H HA   . ASN A 1 3   ? 24.19823  -29.97324 -19.42834 1.000 18.01968  ?  84  ASN A HA   1 
ATOM   38   H HB2  . ASN A 1 3   ? 26.07493  -30.00817 -17.80932 1.000 21.55731  ?  84  ASN A HB2  1 
ATOM   39   H HB3  . ASN A 1 3   ? 26.21524  -28.23305 -17.94403 1.000 21.55731  ?  84  ASN A HB3  1 
ATOM   40   N N    . ASN A 1 4   ? 23.04412  -27.96926 -20.36476 1.000 14.12100  ?  85  ASN A N    1 
ATOM   41   C CA   . ASN A 1 4   ? 22.12041  -26.84161 -20.52162 1.000 13.88957  ?  85  ASN A CA   1 
ATOM   42   C C    . ASN A 1 4   ? 21.08647  -26.93639 -19.40572 1.000 13.45409  ?  85  ASN A C    1 
ATOM   43   O O    . ASN A 1 4   ? 20.39137  -27.95669 -19.31423 1.000 13.84453  ?  85  ASN A O    1 
ATOM   44   C CB   . ASN A 1 4   ? 21.41576  -26.93099 -21.87357 1.000 14.20313  ?  85  ASN A CB   1 
ATOM   45   C CG   . ASN A 1 4   ? 20.50159  -25.73167 -22.13278 1.000 14.24711  ?  85  ASN A CG   1 
ATOM   46   O OD1  . ASN A 1 4   ? 19.83601  -25.26695 -21.20331 1.000 16.72777  ?  85  ASN A OD1  1 
ATOM   47   N ND2  . ASN A 1 4   ? 20.45244  -25.24518 -23.35979 1.000 14.48346  ?  85  ASN A ND2  1 
ATOM   48   H H    A ASN A 1 4   ? 22.75731  -28.81955 -20.84969 0.100 16.94519  ?  85  ASN A H    1 
ATOM   49   D D    B ASN A 1 4   ? 22.75717  -28.81948 -20.84974 0.900 16.94519  ?  85  ASN A D    1 
ATOM   50   H HA   . ASN A 1 4   ? 22.64606  -25.88847 -20.46416 1.000 16.66748  ?  85  ASN A HA   1 
ATOM   51   H HB2  . ASN A 1 4   ? 22.16451  -26.96399 -22.66502 1.000 17.04376  ?  85  ASN A HB2  1 
ATOM   52   H HB3  . ASN A 1 4   ? 20.80594  -27.83407 -21.89940 1.000 17.04376  ?  85  ASN A HB3  1 
ATOM   53   H HD21 A ASN A 1 4   ? 19.85358  -24.44617 -23.56801 0.110 17.38015  ?  85  ASN A HD21 1 
ATOM   54   D DD21 B ASN A 1 4   ? 19.85358  -24.44617 -23.56801 0.890 17.38015  ?  85  ASN A DD21 1 
ATOM   55   H HD22 A ASN A 1 4   ? 21.01333  -25.66852 -24.09911 0.080 17.38015  ?  85  ASN A HD22 1 
ATOM   56   D DD22 B ASN A 1 4   ? 21.01333  -25.66852 -24.09911 0.920 17.38015  ?  85  ASN A DD22 1 
ATOM   57   N N    . PRO A 1 5   ? 20.98990  -25.96880 -18.50111 1.000 12.90171  ?  86  PRO A N    1 
ATOM   58   C CA   . PRO A 1 5   ? 20.09903  -26.14052 -17.32627 1.000 13.83270  ?  86  PRO A CA   1 
ATOM   59   C C    . PRO A 1 5   ? 18.64009  -26.41531 -17.65460 1.000 12.88653  ?  86  PRO A C    1 
ATOM   60   O O    . PRO A 1 5   ? 17.92896  -26.96487 -16.78931 1.000 14.38197  ?  86  PRO A O    1 
ATOM   61   C CB   . PRO A 1 5   ? 20.22778  -24.79711 -16.59089 1.000 15.57484  ?  86  PRO A CB   1 
ATOM   62   C CG   . PRO A 1 5   ? 21.51503  -24.20425 -17.06023 1.000 16.68051  ?  86  PRO A CG   1 
ATOM   63   C CD   . PRO A 1 5   ? 21.69998  -24.67268 -18.48263 1.000 14.09584  ?  86  PRO A CD   1 
ATOM   64   H HA   . PRO A 1 5   ? 20.48568  -26.95668 -16.71596 1.000 16.59924  ?  86  PRO A HA   1 
ATOM   65   H HB2  . PRO A 1 5   ? 19.38724  -24.15338 -16.85012 1.000 18.68980  ?  86  PRO A HB2  1 
ATOM   66   H HB3  . PRO A 1 5   ? 20.24903  -24.96713 -15.51444 1.000 18.68980  ?  86  PRO A HB3  1 
ATOM   67   H HG2  . PRO A 1 5   ? 21.45406  -23.11676 -17.01824 1.000 20.01661  ?  86  PRO A HG2  1 
ATOM   68   H HG3  . PRO A 1 5   ? 22.33163  -24.55647 -16.42999 1.000 20.01661  ?  86  PRO A HG3  1 
ATOM   69   H HD2  . PRO A 1 5   ? 21.24883  -23.97175 -19.18495 1.000 16.91501  ?  86  PRO A HD2  1 
ATOM   70   H HD3  . PRO A 1 5   ? 22.75682  -24.80460 -18.71458 1.000 16.91501  ?  86  PRO A HD3  1 
ATOM   71   N N    . TRP A 1 6   ? 18.15424  -26.04682 -18.82516 1.000 12.21824  ?  87  TRP A N    1 
ATOM   72   C CA   . TRP A 1 6   ? 16.75244  -26.23902 -19.19561 1.000 13.04863  ?  87  TRP A CA   1 
ATOM   73   C C    . TRP A 1 6   ? 16.43863  -27.62338 -19.75281 1.000 14.80260  ?  87  TRP A C    1 
ATOM   74   O O    . TRP A 1 6   ? 15.26739  -28.03158 -19.71528 1.000 16.24302  ?  87  TRP A O    1 
ATOM   75   C CB   . TRP A 1 6   ? 16.31773  -25.16874 -20.20519 1.000 13.44247  ?  87  TRP A CB   1 
ATOM   76   C CG   . TRP A 1 6   ? 16.00715  -23.85168 -19.55067 1.000 11.47721  ?  87  TRP A CG   1 
ATOM   77   C CD1  . TRP A 1 6   ? 14.80110  -23.46938 -19.07657 1.000 13.60059  ?  87  TRP A CD1  1 
ATOM   78   C CD2  . TRP A 1 6   ? 16.90298  -22.77598 -19.29299 1.000 11.16511  ?  87  TRP A CD2  1 
ATOM   79   N NE1  . TRP A 1 6   ? 14.88099  -22.21864 -18.52815 1.000 15.15572  ?  87  TRP A NE1  1 
ATOM   80   C CE2  . TRP A 1 6   ? 16.15833  -21.77492 -18.64216 1.000 12.97607  ?  87  TRP A CE2  1 
ATOM   81   C CE3  . TRP A 1 6   ? 18.25986  -22.57567 -19.52320 1.000 12.72297  ?  87  TRP A CE3  1 
ATOM   82   C CZ2  . TRP A 1 6   ? 16.71323  -20.57217 -18.23181 1.000 14.12735  ?  87  TRP A CZ2  1 
ATOM   83   C CZ3  . TRP A 1 6   ? 18.82079  -21.37420 -19.10612 1.000 13.54440  ?  87  TRP A CZ3  1 
ATOM   84   C CH2  . TRP A 1 6   ? 18.04423  -20.38082 -18.46594 1.000 12.89056  ?  87  TRP A CH2  1 
ATOM   85   H H    A TRP A 1 6   ? 18.70833  -25.60375 -19.55802 1.000 14.66189  ?  87  TRP A H    1 
ATOM   86   D D    B TRP A 1 6   ? 18.70745  -25.60371 -19.55865 0.000 14.66189  ?  87  TRP A D    1 
ATOM   87   H HA   . TRP A 1 6   ? 16.15612  -26.12002 -18.29098 1.000 15.65836  ?  87  TRP A HA   1 
ATOM   88   H HB2  . TRP A 1 6   ? 17.12248  -25.00866 -20.92271 1.000 16.13096  ?  87  TRP A HB2  1 
ATOM   89   H HB3  . TRP A 1 6   ? 15.42043  -25.51007 -20.72138 1.000 16.13096  ?  87  TRP A HB3  1 
ATOM   90   H HD1  . TRP A 1 6   ? 13.90216  -24.06611 -19.12381 1.000 16.32071  ?  87  TRP A HD1  1 
ATOM   91   H HE1  A TRP A 1 6   ? 14.10864  -21.70488 -18.10397 0.910 18.18686  ?  87  TRP A HE1  1 
ATOM   92   D DE1  B TRP A 1 6   ? 14.10864  -21.70488 -18.10397 0.090 18.18686  ?  87  TRP A DE1  1 
ATOM   93   H HE3  . TRP A 1 6   ? 18.85914  -23.33026 -20.01091 1.000 15.26756  ?  87  TRP A HE3  1 
ATOM   94   H HZ2  . TRP A 1 6   ? 16.11510  -19.81575 -17.74554 1.000 16.95282  ?  87  TRP A HZ2  1 
ATOM   95   H HZ3  . TRP A 1 6   ? 19.87249  -21.19550 -19.27464 1.000 16.25328  ?  87  TRP A HZ3  1 
ATOM   96   H HH2  . TRP A 1 6   ? 18.51121  -19.45707 -18.15770 1.000 15.46867  ?  87  TRP A HH2  1 
ATOM   97   N N    . THR A 1 7   ? 17.43477  -28.37151 -20.23686 1.000 14.53811  ?  88  THR A N    1 
ATOM   98   C CA   . THR A 1 7   ? 17.14516  -29.63973 -20.89242 1.000 16.84001  ?  88  THR A CA   1 
ATOM   99   C C    . THR A 1 7   ? 16.52106  -30.60842 -19.88876 1.000 15.98342  ?  88  THR A C    1 
ATOM   100  O O    . THR A 1 7   ? 17.06656  -30.84173 -18.81365 1.000 17.20864  ?  88  THR A O    1 
ATOM   101  C CB   . THR A 1 7   ? 18.42919  -30.25316 -21.44915 1.000 19.41605  ?  88  THR A CB   1 
ATOM   102  O OG1  . THR A 1 7   ? 19.02181  -29.35411 -22.38660 1.000 23.19411  ?  88  THR A OG1  1 
ATOM   103  C CG2  . THR A 1 7   ? 18.09565  -31.56651 -22.15399 1.000 22.35317  ?  88  THR A CG2  1 
ATOM   104  H H    A THR A 1 7   ? 18.42453  -28.12955 -20.18972 0.440 17.44573  ?  88  THR A H    1 
ATOM   105  D D    B THR A 1 7   ? 18.42491  -28.13094 -20.19050 0.560 17.44573  ?  88  THR A D    1 
ATOM   106  H HA   . THR A 1 7   ? 16.45299  -29.46937 -21.71702 1.000 20.20801  ?  88  THR A HA   1 
ATOM   107  H HB   . THR A 1 7   ? 19.13652  -30.44558 -20.64246 1.000 23.29926  ?  88  THR A HB   1 
ATOM   108  H HG1  A THR A 1 7   ? 18.34866  -29.04935 -23.03033 0.090 27.83293  ?  88  THR A HG1  1 
ATOM   109  D DG1  B THR A 1 7   ? 18.36471  -29.09838 -23.06721 0.910 27.83293  ?  88  THR A DG1  1 
ATOM   110  H HG21 . THR A 1 7   ? 18.09200  -31.41951 -23.23403 1.000 26.82381  ?  88  THR A HG21 1 
ATOM   111  H HG22 . THR A 1 7   ? 18.83837  -32.32364 -21.90254 1.000 26.82381  ?  88  THR A HG22 1 
ATOM   112  H HG23 . THR A 1 7   ? 17.11235  -31.91805 -21.84151 1.000 26.82381  ?  88  THR A HG23 1 
ATOM   113  N N    . GLY A 1 8   ? 15.38604  -31.17771 -20.26519 1.000 17.18380  ?  89  GLY A N    1 
ATOM   114  C CA   . GLY A 1 8   ? 14.74211  -32.19412 -19.47143 1.000 19.99303  ?  89  GLY A CA   1 
ATOM   115  C C    . GLY A 1 8   ? 13.83489  -31.67450 -18.38515 1.000 20.49971  ?  89  GLY A C    1 
ATOM   116  O O    . GLY A 1 8   ? 13.32296  -32.48048 -17.59179 1.000 22.96997  ?  89  GLY A O    1 
ATOM   117  H H    A GLY A 1 8   ? 14.88827  -30.94875 -21.12554 0.000 20.62056  ?  89  GLY A H    1 
ATOM   118  D D    B GLY A 1 8   ? 14.88873  -30.94831 -21.12569 1.000 20.62056  ?  89  GLY A D    1 
ATOM   119  H HA2  . GLY A 1 8   ? 14.14406  -32.82375 -20.13022 1.000 23.99163  ?  89  GLY A HA2  1 
ATOM   120  H HA3  . GLY A 1 8   ? 15.51054  -32.80516 -18.99788 1.000 23.99163  ?  89  GLY A HA3  1 
ATOM   121  N N    . PHE A 1 9   ? 13.64466  -30.36050 -18.29295 1.000 15.84746  ?  90  PHE A N    1 
ATOM   122  C CA   . PHE A 1 9   ? 12.80638  -29.75487 -17.26403 1.000 16.04745  ?  90  PHE A CA   1 
ATOM   123  C C    . PHE A 1 9   ? 11.61090  -29.06931 -17.90153 1.000 15.38536  ?  90  PHE A C    1 
ATOM   124  O O    . PHE A 1 9   ? 11.66641  -28.58879 -19.03103 1.000 18.45698  ?  90  PHE A O    1 
ATOM   125  C CB   . PHE A 1 9   ? 13.60410  -28.71736 -16.45487 1.000 15.02830  ?  90  PHE A CB   1 
ATOM   126  C CG   . PHE A 1 9   ? 14.54095  -29.33501 -15.48219 1.000 17.09478  ?  90  PHE A CG   1 
ATOM   127  C CD1  . PHE A 1 9   ? 15.75179  -29.88396 -15.89021 1.000 20.19887  ?  90  PHE A CD1  1 
ATOM   128  C CD2  . PHE A 1 9   ? 14.18432  -29.44299 -14.14945 1.000 18.44469  ?  90  PHE A CD2  1 
ATOM   129  C CE1  . PHE A 1 9   ? 16.58915  -30.52139 -14.96660 1.000 21.95515  ?  90  PHE A CE1  1 
ATOM   130  C CE2  . PHE A 1 9   ? 15.02253  -30.05297 -13.22080 1.000 18.46353  ?  90  PHE A CE2  1 
ATOM   131  C CZ   . PHE A 1 9   ? 16.21439  -30.59941 -13.63242 1.000 20.68225  ?  90  PHE A CZ   1 
ATOM   132  H H    A PHE A 1 9   ? 14.06495  -29.68089 -18.92689 0.000 19.01695  ?  90  PHE A H    1 
ATOM   133  D D    B PHE A 1 9   ? 14.06587  -29.68242 -18.92791 1.000 19.01695  ?  90  PHE A D    1 
ATOM   134  H HA   . PHE A 1 9   ? 12.44045  -30.53072 -16.59154 1.000 19.25694  ?  90  PHE A HA   1 
ATOM   135  H HB2  . PHE A 1 9   ? 14.18829  -28.10578 -17.14247 1.000 18.03396  ?  90  PHE A HB2  1 
ATOM   136  H HB3  . PHE A 1 9   ? 12.90698  -28.09061 -15.89872 1.000 18.03396  ?  90  PHE A HB3  1 
ATOM   137  H HD1  . PHE A 1 9   ? 16.04830  -29.81817 -16.92662 1.000 24.23864  ?  90  PHE A HD1  1 
ATOM   138  H HD2  . PHE A 1 9   ? 13.23484  -29.04524 -13.82283 1.000 22.13362  ?  90  PHE A HD2  1 
ATOM   139  H HE1  . PHE A 1 9   ? 17.52491  -30.95155 -15.29172 1.000 26.34617  ?  90  PHE A HE1  1 
ATOM   140  H HE2  . PHE A 1 9   ? 14.73723  -30.09673 -12.18008 1.000 22.15624  ?  90  PHE A HE2  1 
ATOM   141  H HZ   . PHE A 1 9   ? 16.85928  -31.08941 -12.91799 1.000 24.81870  ?  90  PHE A HZ   1 
ATOM   142  N N    . GLN A 1 10  ? 10.52751  -29.00903 -17.16036 1.000 15.46882  ?  91  GLN A N    1 
ATOM   143  C CA   A GLN A 1 10  ? 9.39698   -28.16866 -17.49785 0.550 15.73916  ?  91  GLN A CA   1 
ATOM   144  C CA   B GLN A 1 10  ? 9.39953   -28.16657 -17.50416 0.450 15.78115  ?  91  GLN A CA   1 
ATOM   145  C C    . GLN A 1 10  ? 9.50216   -26.87652 -16.69496 1.000 14.42074  ?  91  GLN A C    1 
ATOM   146  O O    . GLN A 1 10  ? 9.85053   -26.90020 -15.52177 1.000 16.60523  ?  91  GLN A O    1 
ATOM   147  C CB   A GLN A 1 10  ? 8.10137   -28.87090 -17.11184 0.550 17.84393  ?  91  GLN A CB   1 
ATOM   148  C CB   B GLN A 1 10  ? 8.09131   -28.87023 -17.15230 0.450 18.02115  ?  91  GLN A CB   1 
ATOM   149  C CG   A GLN A 1 10  ? 7.85839   -30.17404 -17.84829 0.550 25.71234  ?  91  GLN A CG   1 
ATOM   150  C CG   B GLN A 1 10  ? 6.84711   -28.17410 -17.69391 0.450 28.36462  ?  91  GLN A CG   1 
ATOM   151  C CD   A GLN A 1 10  ? 7.64263   -29.99082 -19.32876 0.550 31.08723  ?  91  GLN A CD   1 
ATOM   152  C CD   B GLN A 1 10  ? 5.58149   -28.98970 -17.48799 0.450 26.88336  ?  91  GLN A CD   1 
ATOM   153  O OE1  A GLN A 1 10  ? 7.16188   -28.94636 -19.78182 0.550 36.77323  ?  91  GLN A OE1  1 
ATOM   154  O OE1  B GLN A 1 10  ? 4.62518   -28.54022 -16.85228 0.450 29.04696  ?  91  GLN A OE1  1 
ATOM   155  N NE2  A GLN A 1 10  ? 8.00584   -31.01440 -20.10376 0.550 38.61430  ?  91  GLN A NE2  1 
ATOM   156  N NE2  B GLN A 1 10  ? 5.57709   -30.20227 -18.03082 0.450 32.98979  ?  91  GLN A NE2  1 
ATOM   157  H H    A GLN A 1 10  ? 10.39730  -29.54146 -16.30014 0.940 18.56259  ?  91  GLN A H    1 
ATOM   158  D D    B GLN A 1 10  ? 10.39732  -29.54100 -16.29986 0.060 18.56259  ?  91  GLN A D    1 
ATOM   159  H HA   A GLN A 1 10  ? 9.38630   -27.94650 -18.56491 0.550 18.88699  ?  91  GLN A HA   1 
ATOM   160  H HA   B GLN A 1 10  ? 9.39981   -27.93787 -18.56989 0.450 18.93738  ?  91  GLN A HA   1 
ATOM   161  H HB2  A GLN A 1 10  ? 8.13018   -29.09403 -16.04531 0.550 21.41271  ?  91  GLN A HB2  1 
ATOM   162  H HB2  B GLN A 1 10  ? 8.11433   -29.87805 -17.56686 0.450 21.62538  ?  91  GLN A HB2  1 
ATOM   163  H HB3  A GLN A 1 10  ? 7.26584   -28.20617 -17.33121 0.550 21.41271  ?  91  GLN A HB3  1 
ATOM   164  H HB3  B GLN A 1 10  ? 7.99999   -28.91551 -16.06707 0.450 21.62538  ?  91  GLN A HB3  1 
ATOM   165  H HG2  A GLN A 1 10  ? 8.72460   -30.82196 -17.71419 0.550 30.85481  ?  91  GLN A HG2  1 
ATOM   166  H HG2  B GLN A 1 10  ? 6.72129   -27.22093 -17.18036 0.450 34.03754  ?  91  GLN A HG2  1 
ATOM   167  H HG3  A GLN A 1 10  ? 6.96876   -30.65114 -17.43715 0.550 30.85481  ?  91  GLN A HG3  1 
ATOM   168  H HG3  B GLN A 1 10  ? 6.97055   -28.00757 -18.76402 0.450 34.03754  ?  91  GLN A HG3  1 
ATOM   169  N N    . ILE A 1 11  ? 9.22321   -25.76509 -17.30867 1.000 13.19148  ?  92  ILE A N    1 
ATOM   170  C CA   . ILE A 1 11  ? 9.33919   -24.47647 -16.61872 1.000 14.57433  ?  92  ILE A CA   1 
ATOM   171  C C    . ILE A 1 11  ? 8.04836   -24.13988 -15.88369 1.000 12.89999  ?  92  ILE A C    1 
ATOM   172  O O    . ILE A 1 11  ? 6.97073   -24.12711 -16.48704 1.000 15.85886  ?  92  ILE A O    1 
ATOM   173  C CB   . ILE A 1 11  ? 9.71222   -23.35095 -17.59108 1.000 12.76108  ?  92  ILE A CB   1 
ATOM   174  C CG1  . ILE A 1 11  ? 11.00653  -23.67290 -18.35205 1.000 15.55411  ?  92  ILE A CG1  1 
ATOM   175  C CG2  . ILE A 1 11  ? 9.82640   -22.04839 -16.77701 1.000 16.25696  ?  92  ILE A CG2  1 
ATOM   176  C CD1  . ILE A 1 11  ? 11.24123  -22.76735 -19.50386 1.000 19.25598  ?  92  ILE A CD1  1 
ATOM   177  H H    A ILE A 1 11  ? 8.91413   -25.70115 -18.27861 0.110 15.82978  ?  92  ILE A H    1 
ATOM   178  D D    B ILE A 1 11  ? 8.91419   -25.70235 -18.27871 0.890 15.82978  ?  92  ILE A D    1 
ATOM   179  H HA   . ILE A 1 11  ? 10.12644  -24.57749 -15.87164 1.000 17.48919  ?  92  ILE A HA   1 
ATOM   180  H HB   . ILE A 1 11  ? 8.94062   -23.24207 -18.35324 1.000 15.31329  ?  92  ILE A HB   1 
ATOM   181  H HG12 . ILE A 1 11  ? 11.85140  -23.57601 -17.67022 1.000 18.66493  ?  92  ILE A HG12 1 
ATOM   182  H HG13 . ILE A 1 11  ? 10.94927  -24.69288 -18.73213 1.000 18.66493  ?  92  ILE A HG13 1 
ATOM   183  H HG21 . ILE A 1 11  ? 8.82734   -21.72112 -16.48910 1.000 19.50836  ?  92  ILE A HG21 1 
ATOM   184  H HG22 . ILE A 1 11  ? 10.42644  -22.23763 -15.88694 1.000 19.50836  ?  92  ILE A HG22 1 
ATOM   185  H HG23 . ILE A 1 11  ? 10.30432  -21.28609 -17.39232 1.000 19.50836  ?  92  ILE A HG23 1 
ATOM   186  H HD11 . ILE A 1 11  ? 12.13466  -23.09416 -20.03591 1.000 23.10718  ?  92  ILE A HD11 1 
ATOM   187  H HD12 . ILE A 1 11  ? 10.37782  -22.80681 -20.16799 1.000 23.10718  ?  92  ILE A HD12 1 
ATOM   188  H HD13 . ILE A 1 11  ? 11.37960  -21.75137 -19.13407 1.000 23.10718  ?  92  ILE A HD13 1 
ATOM   189  N N    . PHE A 1 12  ? 8.15434   -23.86810 -14.59440 1.000 12.34004  ?  93  PHE A N    1 
ATOM   190  C CA   . PHE A 1 12  ? 7.00527   -23.43838 -13.79627 1.000 12.84268  ?  93  PHE A CA   1 
ATOM   191  C C    . PHE A 1 12  ? 6.55122   -22.05421 -14.22455 1.000 14.74735  ?  93  PHE A C    1 
ATOM   192  O O    . PHE A 1 12  ? 7.34971   -21.12192 -14.31848 1.000 15.33042  ?  93  PHE A O    1 
ATOM   193  C CB   . PHE A 1 12  ? 7.41628   -23.42584 -12.33248 1.000 15.63035  ?  93  PHE A CB   1 
ATOM   194  C CG   . PHE A 1 12  ? 6.31531   -23.04223 -11.39438 1.000 17.51555  ?  93  PHE A CG   1 
ATOM   195  C CD1  . PHE A 1 12  ? 5.27156   -23.90625 -11.14618 1.000 18.54639  ?  93  PHE A CD1  1 
ATOM   196  C CD2  . PHE A 1 12  ? 6.33804   -21.83584 -10.76180 1.000 16.45989  ?  93  PHE A CD2  1 
ATOM   197  C CE1  . PHE A 1 12  ? 4.24182   -23.52610 -10.25724 1.000 18.62909  ?  93  PHE A CE1  1 
ATOM   198  C CE2  . PHE A 1 12  ? 5.33406   -21.46731 -9.88787  1.000 22.42330  ?  93  PHE A CE2  1 
ATOM   199  C CZ   . PHE A 1 12  ? 4.29014   -22.32035 -9.64485  1.000 19.80459  ?  93  PHE A CZ   1 
ATOM   200  H H    A PHE A 1 12  ? 9.02250   -23.93355 -14.06297 1.000 14.80805  ?  93  PHE A H    1 
ATOM   201  D D    B PHE A 1 12  ? 9.02181   -23.93313 -14.06179 0.000 14.80805  ?  93  PHE A D    1 
ATOM   202  H HA   . PHE A 1 12  ? 6.16704   -24.12092 -13.93633 1.000 15.41122  ?  93  PHE A HA   1 
ATOM   203  H HB2  . PHE A 1 12  ? 7.75451   -24.42446 -12.05597 1.000 18.75642  ?  93  PHE A HB2  1 
ATOM   204  H HB3  . PHE A 1 12  ? 8.22684   -22.70862 -12.20329 1.000 18.75642  ?  93  PHE A HB3  1 
ATOM   205  H HD1  . PHE A 1 12  ? 5.24068   -24.87141 -11.62983 1.000 22.25566  ?  93  PHE A HD1  1 
ATOM   206  H HD2  . PHE A 1 12  ? 7.15596   -21.15534 -10.94706 1.000 19.75187  ?  93  PHE A HD2  1 
ATOM   207  H HE1  . PHE A 1 12  ? 3.41707   -24.19679 -10.06656 1.000 22.35491  ?  93  PHE A HE1  1 
ATOM   208  H HE2  . PHE A 1 12  ? 5.37201   -20.50654 -9.39606  1.000 26.90796  ?  93  PHE A HE2  1 
ATOM   209  H HZ   . PHE A 1 12  ? 3.50427   -22.03006 -8.96327  1.000 23.76551  ?  93  PHE A HZ   1 
ATOM   210  N N    . LEU A 1 13  ? 5.26088   -21.89371 -14.50803 1.000 13.85400  ?  94  LEU A N    1 
ATOM   211  C CA   . LEU A 1 13  ? 4.74201   -20.63572 -15.01115 1.000 13.72107  ?  94  LEU A CA   1 
ATOM   212  C C    . LEU A 1 13  ? 4.38065   -19.72345 -13.85801 1.000 16.85663  ?  94  LEU A C    1 
ATOM   213  O O    . LEU A 1 13  ? 3.64614   -20.11788 -12.94838 1.000 20.31985  ?  94  LEU A O    1 
ATOM   214  C CB   . LEU A 1 13  ? 3.49302   -20.88218 -15.86295 1.000 17.09713  ?  94  LEU A CB   1 
ATOM   215  C CG   . LEU A 1 13  ? 3.75301   -21.66308 -17.13044 1.000 17.20248  ?  94  LEU A CG   1 
ATOM   216  C CD1  . LEU A 1 13  ? 2.42774   -22.12560 -17.77149 1.000 21.02412  ?  94  LEU A CD1  1 
ATOM   217  C CD2  . LEU A 1 13  ? 4.55490   -20.80901 -18.12872 1.000 20.23263  ?  94  LEU A CD2  1 
ATOM   218  H H    A LEU A 1 13  ? 4.55402   -22.62074 -14.39762 0.000 16.62480  ?  94  LEU A H    1 
ATOM   219  D D    B LEU A 1 13  ? 4.55466   -22.62131 -14.39732 1.000 16.62480  ?  94  LEU A D    1 
ATOM   220  H HA   . LEU A 1 13  ? 5.50725   -20.15168 -15.61796 1.000 16.46528  ?  94  LEU A HA   1 
ATOM   221  H HB2  . LEU A 1 13  ? 2.77229   -21.44431 -15.26910 1.000 20.51656  ?  94  LEU A HB2  1 
ATOM   222  H HB3  . LEU A 1 13  ? 3.07055   -19.91864 -16.14788 1.000 20.51656  ?  94  LEU A HB3  1 
ATOM   223  H HG   . LEU A 1 13  ? 4.33674   -22.54975 -16.88311 1.000 20.64298  ?  94  LEU A HG   1 
ATOM   224  H HD11 . LEU A 1 13  ? 1.91535   -21.25986 -18.19109 1.000 25.22895  ?  94  LEU A HD11 1 
ATOM   225  H HD12 . LEU A 1 13  ? 2.64715   -22.84576 -18.55974 1.000 25.22895  ?  94  LEU A HD12 1 
ATOM   226  H HD13 . LEU A 1 13  ? 1.80639   -22.59028 -17.00592 1.000 25.22895  ?  94  LEU A HD13 1 
ATOM   227  H HD21 . LEU A 1 13  ? 3.90290   -20.03871 -18.54059 1.000 24.27915  ?  94  LEU A HD21 1 
ATOM   228  H HD22 . LEU A 1 13  ? 5.39298   -20.34673 -17.60716 1.000 24.27915  ?  94  LEU A HD22 1 
ATOM   229  H HD23 . LEU A 1 13  ? 4.92348   -21.45084 -18.92891 1.000 24.27915  ?  94  LEU A HD23 1 
ATOM   230  N N    . SER A 1 14  ? 4.86528   -18.50255 -13.91350 1.000 15.95035  ?  95  SER A N    1 
ATOM   231  C CA   . SER A 1 14  ? 4.59709   -17.54591 -12.85602 1.000 17.35755  ?  95  SER A CA   1 
ATOM   232  C C    . SER A 1 14  ? 3.11666   -17.35458 -12.58242 1.000 19.23321  ?  95  SER A C    1 
ATOM   233  O O    . SER A 1 14  ? 2.39684   -16.87610 -13.46535 1.000 18.58254  ?  95  SER A O    1 
ATOM   234  C CB   . SER A 1 14  ? 5.14403   -16.17961 -13.23636 1.000 18.72344  ?  95  SER A CB   1 
ATOM   235  O OG   . SER A 1 14  ? 4.73934   -15.22198 -12.24796 1.000 24.05389  ?  95  SER A OG   1 
ATOM   236  H H    A SER A 1 14  ? 5.44480   -18.14241 -14.67169 0.210 19.14042  ?  95  SER A H    1 
ATOM   237  D D    B SER A 1 14  ? 5.44484   -18.14184 -14.67139 0.790 19.14042  ?  95  SER A D    1 
ATOM   238  H HA   . SER A 1 14  ? 5.07486   -17.94393 -11.96080 1.000 20.82907  ?  95  SER A HA   1 
ATOM   239  H HB2  . SER A 1 14  ? 6.23247   -16.22255 -13.27578 1.000 22.46813  ?  95  SER A HB2  1 
ATOM   240  H HB3  . SER A 1 14  ? 4.74700   -15.88757 -14.20856 1.000 22.46813  ?  95  SER A HB3  1 
ATOM   241  N N    . PRO A 1 15  ? 2.63445   -17.62104 -11.36051 1.000 19.44251  ?  96  PRO A N    1 
ATOM   242  C CA   . PRO A 1 15  ? 1.21818   -17.32503 -11.06284 1.000 24.37640  ?  96  PRO A CA   1 
ATOM   243  C C    . PRO A 1 15  ? 0.91353   -15.83406 -11.01771 1.000 20.03423  ?  96  PRO A C    1 
ATOM   244  O O    . PRO A 1 15  ? -0.20714  -15.42916 -11.33683 1.000 24.55046  ?  96  PRO A O    1 
ATOM   245  C CB   . PRO A 1 15  ? 1.00700   -17.97737 -9.68328  1.000 33.67560  ?  96  PRO A CB   1 
ATOM   246  C CG   . PRO A 1 15  ? 2.16516   -18.91194 -9.51700  1.000 32.72577  ?  96  PRO A CG   1 
ATOM   247  C CD   . PRO A 1 15  ? 3.30325   -18.33708 -10.26586 1.000 25.01008  ?  96  PRO A CD   1 
ATOM   248  H HA   . PRO A 1 15  ? 0.57409   -17.80614 -11.79890 1.000 29.25168  ?  96  PRO A HA   1 
ATOM   249  H HB2  . PRO A 1 15  ? 1.00808   -17.21242 -8.90678  1.000 40.41072  ?  96  PRO A HB2  1 
ATOM   250  H HB3  . PRO A 1 15  ? 0.06208   -18.52056 -9.67016  1.000 40.41072  ?  96  PRO A HB3  1 
ATOM   251  H HG2  . PRO A 1 15  ? 2.41093   -18.99786 -8.45855  1.000 39.27092  ?  96  PRO A HG2  1 
ATOM   252  H HG3  . PRO A 1 15  ? 1.90067   -19.89002 -9.91890  1.000 39.27092  ?  96  PRO A HG3  1 
ATOM   253  H HD2  . PRO A 1 15  ? 3.87582   -17.65101 -9.64171  1.000 30.01210  ?  96  PRO A HD2  1 
ATOM   254  H HD3  . PRO A 1 15  ? 3.95417   -19.12168 -10.65160 1.000 30.01210  ?  96  PRO A HD3  1 
ATOM   255  N N    . TYR A 1 16  ? 1.89742   -15.02265 -10.65383 1.000 22.42589  ?  97  TYR A N    1 
ATOM   256  C CA   . TYR A 1 16  ? 1.66907   -13.58616 -10.55178 1.000 20.90685  ?  97  TYR A CA   1 
ATOM   257  C C    . TYR A 1 16  ? 1.46305   -12.99984 -11.93633 1.000 21.65066  ?  97  TYR A C    1 
ATOM   258  O O    . TYR A 1 16  ? 0.43680   -12.36633 -12.20777 1.000 22.47249  ?  97  TYR A O    1 
ATOM   259  C CB   . TYR A 1 16  ? 2.85052   -12.92744 -9.88291  1.000 24.55785  ?  97  TYR A CB   1 
ATOM   260  C CG   . TYR A 1 16  ? 2.62554   -11.46256 -9.65421  1.000 36.28155  ?  97  TYR A CG   1 
ATOM   261  C CD1  . TYR A 1 16  ? 1.79716   -11.02520 -8.62675  1.000 47.17545  ?  97  TYR A CD1  1 
ATOM   262  C CD2  . TYR A 1 16  ? 3.23009   -10.50981 -10.46885 1.000 28.98978  ?  97  TYR A CD2  1 
ATOM   263  C CE1  . TYR A 1 16  ? 1.58543   -9.68215  -8.40856  1.000 41.68299  ?  97  TYR A CE1  1 
ATOM   264  C CE2  . TYR A 1 16  ? 3.02633   -9.17137  -10.26296 1.000 34.37306  ?  97  TYR A CE2  1 
ATOM   265  C CZ   . TYR A 1 16  ? 2.19619   -8.75972  -9.23377  1.000 39.93405  ?  97  TYR A CZ   1 
ATOM   266  O OH   . TYR A 1 16  ? 1.99395   -7.41450  -9.02341  1.000 50.65913  ?  97  TYR A OH   1 
ATOM   267  H H    A TYR A 1 16  ? 2.84635   -15.31998 -10.42683 0.110 26.91107  ?  97  TYR A H    1 
ATOM   268  D D    B TYR A 1 16  ? 2.84695   -15.31773 -10.42641 0.890 26.91107  ?  97  TYR A D    1 
ATOM   269  H HA   . TYR A 1 16  ? 0.78387   -13.39799 -9.94423  1.000 25.08822  ?  97  TYR A HA   1 
ATOM   270  H HB2  . TYR A 1 16  ? 3.02356   -13.40037 -8.91621  1.000 29.46942  ?  97  TYR A HB2  1 
ATOM   271  H HB3  . TYR A 1 16  ? 3.72988   -13.04201 -10.51672 1.000 29.46942  ?  97  TYR A HB3  1 
ATOM   272  H HD1  . TYR A 1 16  ? 1.31220   -11.75015 -7.98984  1.000 56.61055  ?  97  TYR A HD1  1 
ATOM   273  H HD2  . TYR A 1 16  ? 3.87055   -10.83136 -11.27682 1.000 34.78774  ?  97  TYR A HD2  1 
ATOM   274  H HE1  . TYR A 1 16  ? 0.94837   -9.35418  -7.60048  1.000 50.01959  ?  97  TYR A HE1  1 
ATOM   275  H HE2  . TYR A 1 16  ? 3.50891   -8.44303  -10.89782 1.000 41.24768  ?  97  TYR A HE2  1 
ATOM   276  N N    . TYR A 1 17  ? 2.36883   -13.31537 -12.87377 1.000 19.80595  ?  98  TYR A N    1 
ATOM   277  C CA   . TYR A 1 17  ? 2.17545   -12.83532 -14.22880 1.000 15.90705  ?  98  TYR A CA   1 
ATOM   278  C C    . TYR A 1 17  ? 0.91952   -13.42948 -14.82833 1.000 19.90207  ?  98  TYR A C    1 
ATOM   279  O O    . TYR A 1 17  ? 0.20130   -12.75513 -15.57453 1.000 17.91236  ?  98  TYR A O    1 
ATOM   280  C CB   . TYR A 1 17  ? 3.39915   -13.18876 -15.07747 1.000 16.21865  ?  98  TYR A CB   1 
ATOM   281  C CG   . TYR A 1 17  ? 3.45219   -12.49404 -16.40674 1.000 13.69193  ?  98  TYR A CG   1 
ATOM   282  C CD1  . TYR A 1 17  ? 3.49851   -11.10622 -16.48316 1.000 15.47541  ?  98  TYR A CD1  1 
ATOM   283  C CD2  . TYR A 1 17  ? 3.48829   -13.20974 -17.57754 1.000 15.43154  ?  98  TYR A CD2  1 
ATOM   284  C CE1  . TYR A 1 17  ? 3.57262   -10.45730 -17.68218 1.000 15.85661  ?  98  TYR A CE1  1 
ATOM   285  C CE2  . TYR A 1 17  ? 3.57897   -12.56812 -18.79025 1.000 14.96476  ?  98  TYR A CE2  1 
ATOM   286  C CZ   . TYR A 1 17  ? 3.60917   -11.20116 -18.84397 1.000 15.44975  ?  98  TYR A CZ   1 
ATOM   287  O OH   . TYR A 1 17  ? 3.68563   -10.56590 -20.07153 1.000 17.74101  ?  98  TYR A OH   1 
ATOM   288  H H    A TYR A 1 17  ? 3.20658   -13.87734 -12.72287 0.030 23.76714  ?  98  TYR A H    1 
ATOM   289  D D    B TYR A 1 17  ? 3.20721   -13.87706 -12.72539 0.970 23.76714  ?  98  TYR A D    1 
ATOM   290  H HA   . TYR A 1 17  ? 2.07061   -11.75040 -14.22172 1.000 19.08846  ?  98  TYR A HA   1 
ATOM   291  H HB2  . TYR A 1 17  ? 4.29718   -12.91253 -14.52489 1.000 19.46238  ?  98  TYR A HB2  1 
ATOM   292  H HB3  . TYR A 1 17  ? 3.39310   -14.26225 -15.26638 1.000 19.46238  ?  98  TYR A HB3  1 
ATOM   293  H HD1  . TYR A 1 17  ? 3.47529   -10.52747 -15.57161 1.000 18.57049  ?  98  TYR A HD1  1 
ATOM   294  H HD2  . TYR A 1 17  ? 3.44501   -14.28841 -17.54581 1.000 18.51784  ?  98  TYR A HD2  1 
ATOM   295  H HE1  . TYR A 1 17  ? 3.60219   -9.37839  -17.72078 1.000 19.02793  ?  98  TYR A HE1  1 
ATOM   296  H HE2  . TYR A 1 17  ? 3.62645   -13.14435 -19.70245 1.000 17.95772  ?  98  TYR A HE2  1 
ATOM   297  H HH   A TYR A 1 17  ? 3.72734   -9.59507  -19.94450 0.050 21.28921  ?  98  TYR A HH   1 
ATOM   298  D DH   B TYR A 1 17  ? 3.77930   -9.59886  -19.94323 0.950 21.28921  ?  98  TYR A DH   1 
ATOM   299  N N    . ALA A 1 18  ? 0.62833   -14.69994 -14.52917 1.000 18.40124  ?  99  ALA A N    1 
ATOM   300  C CA   . ALA A 1 18  ? -0.59032  -15.29193 -15.08188 1.000 20.59102  ?  99  ALA A CA   1 
ATOM   301  C C    . ALA A 1 18  ? -1.82172  -14.49588 -14.65116 1.000 20.32293  ?  99  ALA A C    1 
ATOM   302  O O    . ALA A 1 18  ? -2.72280  -14.25800 -15.45798 1.000 23.37888  ?  99  ALA A O    1 
ATOM   303  C CB   . ALA A 1 18  ? -0.70906  -16.77836 -14.70937 1.000 21.29936  ?  99  ALA A CB   1 
ATOM   304  H H    A ALA A 1 18  ? 1.18770   -15.31396 -13.93716 0.730 22.08149  ?  99  ALA A H    1 
ATOM   305  D D    B ALA A 1 18  ? 1.18598   -15.31587 -13.93752 0.270 22.08149  ?  99  ALA A D    1 
ATOM   306  H HA   . ALA A 1 18  ? -0.53366  -15.25928 -16.16992 1.000 24.70922  ?  99  ALA A HA   1 
ATOM   307  H HB1  . ALA A 1 18  ? -0.46572  -17.38359 -15.58263 1.000 25.55923  ?  99  ALA A HB1  1 
ATOM   308  H HB2  . ALA A 1 18  ? -0.01344  -16.99790 -13.89943 1.000 25.55923  ?  99  ALA A HB2  1 
ATOM   309  H HB3  . ALA A 1 18  ? -1.73028  -16.98320 -14.38804 1.000 25.55923  ?  99  ALA A HB3  1 
ATOM   310  N N    . ASN A 1 19  ? -1.83871  -14.05514 -13.40363 1.000 21.04906  ?  100 ASN A N    1 
ATOM   311  C CA   . ASN A 1 19  ? -2.98464  -13.30678 -12.87615 1.000 24.28089  ?  100 ASN A CA   1 
ATOM   312  C C    . ASN A 1 19  ? -3.05033  -11.91110 -13.48186 1.000 27.34763  ?  100 ASN A C    1 
ATOM   313  O O    . ASN A 1 19  ? -4.14050  -11.42579 -13.80294 1.000 24.67277  ?  100 ASN A O    1 
ATOM   314  C CB   . ASN A 1 19  ? -2.86889  -13.21867 -11.35471 1.000 26.95246  ?  100 ASN A CB   1 
ATOM   315  C CG   . ASN A 1 19  ? -3.37654  -14.46486 -10.66038 1.000 46.94615  ?  100 ASN A CG   1 
ATOM   316  O OD1  . ASN A 1 19  ? -4.21589  -15.19306 -11.20277 1.000 51.70554  ?  100 ASN A OD1  1 
ATOM   317  N ND2  . ASN A 1 19  ? -2.87497  -14.71934 -9.45394  1.000 43.83654  ?  100 ASN A ND2  1 
ATOM   318  H H    A ASN A 1 19  ? -1.08547  -14.19338 -12.72990 0.210 25.25888  ?  100 ASN A H    1 
ATOM   319  D D    B ASN A 1 19  ? -1.08690  -14.19203 -12.72803 0.790 25.25888  ?  100 ASN A D    1 
ATOM   320  H HA   . ASN A 1 19  ? -3.90707  -13.82980 -13.12848 1.000 29.13707  ?  100 ASN A HA   1 
ATOM   321  H HB2  . ASN A 1 19  ? -1.82152  -13.08411 -11.08450 1.000 32.34296  ?  100 ASN A HB2  1 
ATOM   322  H HB3  . ASN A 1 19  ? -3.45685  -12.37160 -11.00135 1.000 32.34296  ?  100 ASN A HB3  1 
ATOM   323  N N    . GLU A 1 20  ? -1.89620  -11.24997 -13.65944 1.000 21.41651  ?  101 GLU A N    1 
ATOM   324  C CA   . GLU A 1 20  ? -1.87819  -9.96977  -14.36734 1.000 19.26982  ?  101 GLU A CA   1 
ATOM   325  C C    . GLU A 1 20  ? -2.43012  -10.12057 -15.76879 1.000 19.22385  ?  101 GLU A C    1 
ATOM   326  O O    . GLU A 1 20  ? -3.24400  -9.31149  -16.22930 1.000 22.10931  ?  101 GLU A O    1 
ATOM   327  C CB   . GLU A 1 20  ? -0.46012  -9.39084  -14.43518 1.000 20.37876  ?  101 GLU A CB   1 
ATOM   328  C CG   . GLU A 1 20  ? 0.13024   -9.05986  -13.09205 1.000 22.63195  ?  101 GLU A CG   1 
ATOM   329  C CD   . GLU A 1 20  ? 1.49725   -8.43998  -13.20147 1.000 23.53237  ?  101 GLU A CD   1 
ATOM   330  O OE1  . GLU A 1 20  ? 2.40786   -9.04209  -13.72487 1.000 20.73787  ?  101 GLU A OE1  1 
ATOM   331  O OE2  . GLU A 1 20  ? 1.62107   -7.23049  -12.73175 1.000 25.06543  -1 101 GLU A OE2  1 
ATOM   332  H H    A GLU A 1 20  ? -0.98398  -11.56859 -13.33271 0.150 25.69981  ?  101 GLU A H    1 
ATOM   333  D D    B GLU A 1 20  ? -0.98298  -11.56665 -13.33363 0.850 25.69981  ?  101 GLU A D    1 
ATOM   334  H HA   . GLU A 1 20  ? -2.49913  -9.27230  -13.80515 1.000 23.12379  ?  101 GLU A HA   1 
ATOM   335  H HB2  . GLU A 1 20  ? 0.19273   -10.12090 -14.91361 1.000 24.45452  ?  101 GLU A HB2  1 
ATOM   336  H HB3  . GLU A 1 20  ? -0.48542  -8.47247  -15.02174 1.000 24.45452  ?  101 GLU A HB3  1 
ATOM   337  H HG2  . GLU A 1 20  ? -0.52223  -8.35225  -12.58051 1.000 27.15834  ?  101 GLU A HG2  1 
ATOM   338  H HG3  . GLU A 1 20  ? 0.21952   -9.97498  -12.50666 1.000 27.15834  ?  101 GLU A HG3  1 
ATOM   339  D DE2  . GLU A 1 20  ? 2.58599   -6.93009  -12.86995 0.190 30.07852  ?  101 GLU A DE2  1 
ATOM   340  N N    . VAL A 1 21  ? -1.99789  -11.15383 -16.47975 1.000 18.71339  ?  102 VAL A N    1 
ATOM   341  C CA   . VAL A 1 21  ? -2.41064  -11.33757 -17.86369 1.000 18.46210  ?  102 VAL A CA   1 
ATOM   342  C C    . VAL A 1 21  ? -3.89388  -11.67775 -17.94289 1.000 21.15531  ?  102 VAL A C    1 
ATOM   343  O O    . VAL A 1 21  ? -4.60034  -11.19560 -18.83511 1.000 23.78845  ?  102 VAL A O    1 
ATOM   344  C CB   . VAL A 1 21  ? -1.54703  -12.43542 -18.51063 1.000 17.79914  ?  102 VAL A CB   1 
ATOM   345  C CG1  . VAL A 1 21  ? -2.08995  -12.82436 -19.84549 1.000 20.95024  ?  102 VAL A CG1  1 
ATOM   346  C CG2  . VAL A 1 21  ? -0.13245  -11.93460 -18.68763 1.000 22.86230  ?  102 VAL A CG2  1 
ATOM   347  H H    A VAL A 1 21  ? -1.36695  -11.87541 -16.13100 0.960 22.45607  ?  102 VAL A H    1 
ATOM   348  D D    B VAL A 1 21  ? -1.36702  -11.87652 -16.13317 0.040 22.45607  ?  102 VAL A D    1 
ATOM   349  H HA   . VAL A 1 21  ? -2.25801  -10.40403 -18.40526 1.000 22.15453  ?  102 VAL A HA   1 
ATOM   350  H HB   . VAL A 1 21  ? -1.55544  -13.30919 -17.85906 1.000 21.35896  ?  102 VAL A HB   1 
ATOM   351  H HG11 . VAL A 1 21  ? -1.28969  -13.26649 -20.43896 1.000 25.14029  ?  102 VAL A HG11 1 
ATOM   352  H HG12 . VAL A 1 21  ? -2.89220  -13.54874 -19.70494 1.000 25.14029  ?  102 VAL A HG12 1 
ATOM   353  H HG13 . VAL A 1 21  ? -2.47520  -11.93525 -20.34466 1.000 25.14029  ?  102 VAL A HG13 1 
ATOM   354  H HG21 . VAL A 1 21  ? -0.12951  -10.84695 -18.61613 1.000 27.43476  ?  102 VAL A HG21 1 
ATOM   355  H HG22 . VAL A 1 21  ? 0.49527   -12.36026 -17.90476 1.000 27.43476  ?  102 VAL A HG22 1 
ATOM   356  H HG23 . VAL A 1 21  ? 0.23356   -12.24373 -19.66670 1.000 27.43476  ?  102 VAL A HG23 1 
ATOM   357  N N    . ALA A 1 22  ? -4.37776  -12.53429 -17.04736 1.000 24.75477  ?  103 ALA A N    1 
ATOM   358  C CA   . ALA A 1 22  ? -5.80158  -12.87295 -17.08023 1.000 25.54633  ?  103 ALA A CA   1 
ATOM   359  C C    . ALA A 1 22  ? -6.65673  -11.62578 -16.87901 1.000 25.34500  ?  103 ALA A C    1 
ATOM   360  O O    . ALA A 1 22  ? -7.63691  -11.41395 -17.60099 1.000 30.36698  ?  103 ALA A O    1 
ATOM   361  C CB   . ALA A 1 22  ? -6.12133  -13.94280 -16.03440 1.000 29.21111  ?  103 ALA A CB   1 
ATOM   362  H H    A ALA A 1 22  ? -3.83603  -12.99378 -16.31537 1.000 29.70572  ?  103 ALA A H    1 
ATOM   363  D D    B ALA A 1 22  ? -3.83819  -12.99501 -16.31455 0.000 29.70572  ?  103 ALA A D    1 
ATOM   364  H HA   . ALA A 1 22  ? -6.04683  -13.29624 -18.05429 1.000 30.65560  ?  103 ALA A HA   1 
ATOM   365  H HB1  . ALA A 1 22  ? -6.41119  -14.86174 -16.54395 1.000 35.05333  ?  103 ALA A HB1  1 
ATOM   366  H HB2  . ALA A 1 22  ? -5.23505  -14.11940 -15.42496 1.000 35.05333  ?  103 ALA A HB2  1 
ATOM   367  H HB3  . ALA A 1 22  ? -6.94026  -13.59174 -15.40654 1.000 35.05333  ?  103 ALA A HB3  1 
ATOM   368  N N    . ALA A 1 23  ? -6.27753  -10.78053 -15.92824 1.000 23.33531  ?  104 ALA A N    1 
ATOM   369  C CA   . ALA A 1 23  ? -7.01908  -9.54203  -15.68732 1.000 23.35852  ?  104 ALA A CA   1 
ATOM   370  C C    . ALA A 1 23  ? -6.91803  -8.62294  -16.89025 1.000 31.65437  ?  104 ALA A C    1 
ATOM   371  O O    . ALA A 1 23  ? -7.89628  -7.97239  -17.27245 1.000 33.26151  ?  104 ALA A O    1 
ATOM   372  C CB   . ALA A 1 23  ? -6.47727  -8.86200  -14.43602 1.000 24.04761  ?  104 ALA A CB   1 
ATOM   373  H H    A ALA A 1 23  ? -5.47458  -10.91707 -15.31421 0.110 28.00237  ?  104 ALA A H    1 
ATOM   374  D D    B ALA A 1 23  ? -5.47512  -10.91472 -15.31299 0.890 28.00237  ?  104 ALA A D    1 
ATOM   375  H HA   . ALA A 1 23  ? -8.07227  -9.76659  -15.51862 1.000 28.03022  ?  104 ALA A HA   1 
ATOM   376  H HB1  . ALA A 1 23  ? -5.96280  -7.94546  -14.72476 1.000 28.85713  ?  104 ALA A HB1  1 
ATOM   377  H HB2  . ALA A 1 23  ? -7.30866  -8.62791  -13.77112 1.000 28.85713  ?  104 ALA A HB2  1 
ATOM   378  H HB3  . ALA A 1 23  ? -5.78179  -9.53751  -13.93792 1.000 28.85713  ?  104 ALA A HB3  1 
ATOM   379  N N    . ALA A 1 24  ? -5.74573  -8.58442  -17.53072 1.000 23.53215  ?  105 ALA A N    1 
ATOM   380  C CA   . ALA A 1 24  ? -5.55821  -7.72306  -18.68338 1.000 21.34326  ?  105 ALA A CA   1 
ATOM   381  C C    . ALA A 1 24  ? -6.38579  -8.18722  -19.86424 1.000 24.99245  ?  105 ALA A C    1 
ATOM   382  O O    . ALA A 1 24  ? -6.91807  -7.36087  -20.61558 1.000 26.07519  ?  105 ALA A O    1 
ATOM   383  C CB   . ALA A 1 24  ? -4.08022  -7.67567  -19.06826 1.000 21.15711  ?  105 ALA A CB   1 
ATOM   384  H H    A ALA A 1 24  ? -4.92382  -9.13153  -17.27471 1.000 28.23858  ?  105 ALA A H    1 
ATOM   385  D D    B ALA A 1 24  ? -4.92246  -9.13043  -17.27674 0.000 28.23858  ?  105 ALA A D    1 
ATOM   386  H HA   . ALA A 1 24  ? -5.87894  -6.71630  -18.41569 1.000 25.61191  ?  105 ALA A HA   1 
ATOM   387  H HB1  . ALA A 1 24  ? -3.96548  -7.06054  -19.96076 1.000 25.38853  ?  105 ALA A HB1  1 
ATOM   388  H HB2  . ALA A 1 24  ? -3.51250  -7.24413  -18.24390 1.000 25.38853  ?  105 ALA A HB2  1 
ATOM   389  H HB3  . ALA A 1 24  ? -3.73292  -8.68931  -19.26828 1.000 25.38853  ?  105 ALA A HB3  1 
ATOM   390  N N    . ALA A 1 25  ? -6.48726  -9.50445  -20.07436 1.000 27.20294  ?  106 ALA A N    1 
ATOM   391  C CA   . ALA A 1 25  ? -7.14775  -9.96851  -21.28380 1.000 27.39902  ?  106 ALA A CA   1 
ATOM   392  C C    . ALA A 1 25  ? -8.66030  -9.71067  -21.21939 1.000 27.91229  ?  106 ALA A C    1 
ATOM   393  O O    . ALA A 1 25  ? -9.31361  -9.59605  -22.26184 1.000 33.06758  ?  106 ALA A O    1 
ATOM   394  C CB   . ALA A 1 25  ? -6.86356  -11.44573 -21.53889 1.000 30.61553  ?  106 ALA A CB   1 
ATOM   395  H H    A ALA A 1 25  ? -6.13776  -10.23431 -19.45343 0.920 32.64352  ?  106 ALA A H    1 
ATOM   396  D D    B ALA A 1 25  ? -6.13862  -10.23608 -19.45503 0.080 32.64352  ?  106 ALA A D    1 
ATOM   397  H HA   . ALA A 1 25  ? -6.73767  -9.42072  -22.13224 1.000 32.87882  ?  106 ALA A HA   1 
ATOM   398  H HB1  . ALA A 1 25  ? -6.64480  -11.58741 -22.59727 1.000 36.73863  ?  106 ALA A HB1  1 
ATOM   399  H HB2  . ALA A 1 25  ? -6.00690  -11.75120 -20.93813 1.000 36.73863  ?  106 ALA A HB2  1 
ATOM   400  H HB3  . ALA A 1 25  ? -7.74070  -12.02929 -21.25927 1.000 36.73863  ?  106 ALA A HB3  1 
ATOM   401  N N    . LYS A 1 26  ? -9.21952  -9.62489  -20.01177 1.000 30.47495  ?  107 LYS A N    1 
ATOM   402  C CA   . LYS A 1 26  ? -10.65671 -9.34919  -19.88549 1.000 36.98481  ?  107 LYS A CA   1 
ATOM   403  C C    . LYS A 1 26  ? -10.97106 -7.91354  -20.28882 1.000 44.75102  ?  107 LYS A C    1 
ATOM   404  O O    . LYS A 1 26  ? -12.09989 -7.61167  -20.69613 1.000 57.90617  ?  107 LYS A O    1 
ATOM   405  C CB   . LYS A 1 26  ? -11.14265 -9.57394  -18.45083 1.000 33.48722  ?  107 LYS A CB   1 
ATOM   406  C CG   . LYS A 1 26  ? -11.05746 -11.01200 -17.93062 1.000 43.94758  ?  107 LYS A CG   1 
ATOM   407  C CD   . LYS A 1 26  ? -11.50346 -11.12303 -16.44555 1.000 65.08366  ?  107 LYS A CD   1 
ATOM   408  C CE   . LYS A 1 26  ? -10.46262 -11.80744 -15.52250 1.000 65.74116  ?  107 LYS A CE   1 
ATOM   409  N NZ   . LYS A 1 26  ? -10.18290 -13.26929 -15.80259 1.000 57.39438  ?  107 LYS A NZ   1 
ATOM   410  H H    A LYS A 1 26  ? -8.72481  -9.73703  -19.12685 0.120 36.56994  ?  107 LYS A H    1 
ATOM   411  D D    B LYS A 1 26  ? -8.72704  -9.73662  -19.12556 0.880 36.56994  ?  107 LYS A D    1 
ATOM   412  H HA   . LYS A 1 26  ? -11.18915 -10.04467 -20.53427 1.000 44.38178  ?  107 LYS A HA   1 
ATOM   413  H HB2  . LYS A 1 26  ? -10.53997 -8.95491  -17.78623 1.000 40.18466  ?  107 LYS A HB2  1 
ATOM   414  H HB3  . LYS A 1 26  ? -12.18864 -9.27258  -18.39441 1.000 40.18466  ?  107 LYS A HB3  1 
ATOM   415  H HG2  . LYS A 1 26  ? -11.70818 -11.64918 -18.52950 1.000 52.73709  ?  107 LYS A HG2  1 
ATOM   416  H HG3  . LYS A 1 26  ? -10.02671 -11.35905 -18.00282 1.000 52.73709  ?  107 LYS A HG3  1 
ATOM   417  H HD2  . LYS A 1 26  ? -11.68032 -10.12001 -16.05726 1.000 78.10039  ?  107 LYS A HD2  1 
ATOM   418  H HD3  . LYS A 1 26  ? -12.42186 -11.70823 -16.39871 1.000 78.10039  ?  107 LYS A HD3  1 
ATOM   419  H HE2  . LYS A 1 26  ? -9.51663  -11.27518 -15.62197 1.000 78.88939  ?  107 LYS A HE2  1 
ATOM   420  H HE3  . LYS A 1 26  ? -10.82172 -11.74073 -14.49552 1.000 78.88939  ?  107 LYS A HE3  1 
ATOM   421  N N    . GLN A 1 27  ? -9.99374  -7.01101  -20.16578 1.000 41.78384  ?  108 GLN A N    1 
ATOM   422  C CA   . GLN A 1 27  ? -10.19080 -5.60413  -20.49889 1.000 35.45236  ?  108 GLN A CA   1 
ATOM   423  C C    . GLN A 1 27  ? -9.99652  -5.32103  -21.98225 1.000 37.21463  ?  108 GLN A C    1 
ATOM   424  O O    . GLN A 1 27  ? -10.20150 -4.18071  -22.41772 1.000 45.53741  ?  108 GLN A O    1 
ATOM   425  C CB   . GLN A 1 27  ? -9.23088  -4.73678  -19.68393 1.000 29.22352  ?  108 GLN A CB   1 
ATOM   426  C CG   . GLN A 1 27  ? -9.41190  -4.83529  -18.17241 1.000 40.50211  ?  108 GLN A CG   1 
ATOM   427  C CD   . GLN A 1 27  ? -8.34696  -4.03871  -17.41002 1.000 80.54351  ?  108 GLN A CD   1 
ATOM   428  O OE1  . GLN A 1 27  ? -8.50504  -2.83991  -17.17670 1.000 81.60446  ?  108 GLN A OE1  1 
ATOM   429  N NE2  . GLN A 1 27  ? -7.24995  -4.70350  -17.03586 1.000 67.08530  ?  108 GLN A NE2  1 
ATOM   430  H H    A GLN A 1 27  ? -9.05296  -7.22784  -19.83669 0.000 50.14061  ?  108 GLN A H    1 
ATOM   431  D D    B GLN A 1 27  ? -9.05307  -7.22827  -19.83664 1.000 50.14061  ?  108 GLN A D    1 
ATOM   432  H HA   . GLN A 1 27  ? -11.20882 -5.32005  -20.23235 1.000 42.54283  ?  108 GLN A HA   1 
ATOM   433  H HB2  . GLN A 1 27  ? -8.20957  -5.04102  -19.91300 1.000 35.06823  ?  108 GLN A HB2  1 
ATOM   434  H HB3  . GLN A 1 27  ? -9.38148  -3.69462  -19.96560 1.000 35.06823  ?  108 GLN A HB3  1 
ATOM   435  H HG2  . GLN A 1 27  ? -10.39084 -4.43906  -17.90263 1.000 48.60254  ?  108 GLN A HG2  1 
ATOM   436  H HG3  . GLN A 1 27  ? -9.33632  -5.87984  -17.87024 1.000 48.60254  ?  108 GLN A HG3  1 
ATOM   437  N N    . ILE A 1 28  ? -9.59842  -6.32126  -22.75786 1.000 33.70307  ?  109 ILE A N    1 
ATOM   438  C CA   . ILE A 1 28  ? -9.38310  -6.16212  -24.18854 1.000 31.52789  ?  109 ILE A CA   1 
ATOM   439  C C    . ILE A 1 28  ? -10.68817 -6.55095  -24.86330 1.000 41.50635  ?  109 ILE A C    1 
ATOM   440  O O    . ILE A 1 28  ? -11.17097 -7.67046  -24.69346 1.000 37.90622  ?  109 ILE A O    1 
ATOM   441  C CB   . ILE A 1 28  ? -8.20818  -7.02176  -24.67706 1.000 32.57813  ?  109 ILE A CB   1 
ATOM   442  C CG1  . ILE A 1 28  ? -6.90818  -6.43269  -24.13913 1.000 28.90450  ?  109 ILE A CG1  1 
ATOM   443  C CG2  . ILE A 1 28  ? -8.18229  -7.08348  -26.18791 1.000 34.06778  ?  109 ILE A CG2  1 
ATOM   444  C CD1  . ILE A 1 28  ? -5.72435  -7.38846  -24.14741 1.000 29.79106  ?  109 ILE A CD1  1 
ATOM   445  H H    A ILE A 1 28  ? -9.41449  -7.26576  -22.41951 0.290 40.44368  ?  109 ILE A H    1 
ATOM   446  D D    B ILE A 1 28  ? -9.41479  -7.26540  -22.41835 0.710 40.44368  ?  109 ILE A D    1 
ATOM   447  H HA   . ILE A 1 28  ? -9.14497  -5.12671  -24.43209 1.000 37.83347  ?  109 ILE A HA   1 
ATOM   448  H HB   . ILE A 1 28  ? -8.32775  -8.03940  -24.30530 1.000 39.09376  ?  109 ILE A HB   1 
ATOM   449  H HG12 . ILE A 1 28  ? -6.63890  -5.57184  -24.75112 1.000 34.68541  ?  109 ILE A HG12 1 
ATOM   450  H HG13 . ILE A 1 28  ? -7.07040  -6.12055  -23.10745 1.000 34.68541  ?  109 ILE A HG13 1 
ATOM   451  H HG21 . ILE A 1 28  ? -9.18963  -7.28520  -26.55214 1.000 40.88133  ?  109 ILE A HG21 1 
ATOM   452  H HG22 . ILE A 1 28  ? -7.83116  -6.12741  -26.57616 1.000 40.88133  ?  109 ILE A HG22 1 
ATOM   453  H HG23 . ILE A 1 28  ? -7.50785  -7.88127  -26.49898 1.000 40.88133  ?  109 ILE A HG23 1 
ATOM   454  H HD11 . ILE A 1 28  ? -6.08864  -8.40321  -24.30770 1.000 35.74927  ?  109 ILE A HD11 1 
ATOM   455  H HD12 . ILE A 1 28  ? -5.04563  -7.10575  -24.95209 1.000 35.74927  ?  109 ILE A HD12 1 
ATOM   456  H HD13 . ILE A 1 28  ? -5.21046  -7.32519  -23.18823 1.000 35.74927  ?  109 ILE A HD13 1 
ATOM   457  N N    . THR A 1 29  ? -11.26549 -5.61977  -25.60783 1.000 44.76608  ?  110 THR A N    1 
ATOM   458  C CA   . THR A 1 29  ? -12.65361 -5.74026  -26.03352 1.000 48.65251  ?  110 THR A CA   1 
ATOM   459  C C    . THR A 1 29  ? -12.79581 -6.54368  -27.30452 1.000 42.87569  ?  110 THR A C    1 
ATOM   460  O O    . THR A 1 29  ? -13.81768 -7.21749  -27.48654 1.000 57.14766  ?  110 THR A O    1 
ATOM   461  C CB   . THR A 1 29  ? -13.28404 -4.35145  -26.20994 1.000 38.53330  ?  110 THR A CB   1 
ATOM   462  O OG1  . THR A 1 29  ? -12.48042 -3.57024  -27.10644 1.000 39.98846  ?  110 THR A OG1  1 
ATOM   463  C CG2  . THR A 1 29  ? -13.39229 -3.64801  -24.84016 1.000 33.23382  ?  110 THR A CG2  1 
ATOM   464  H H    A THR A 1 29  ? -10.80148 -4.77153  -25.93279 0.260 53.71930  ?  110 THR A H    1 
ATOM   465  D D    B THR A 1 29  ? -10.80177 -4.77144  -25.93295 0.740 53.71930  ?  110 THR A D    1 
ATOM   466  H HA   . THR A 1 29  ? -13.22156 -6.24897  -25.25458 1.000 58.38301  ?  110 THR A HA   1 
ATOM   467  H HB   . THR A 1 29  ? -14.28658 -4.44163  -26.62811 1.000 46.23996  ?  110 THR A HB   1 
ATOM   468  H HG21 . THR A 1 29  ? -13.87179 -2.67615  -24.95702 1.000 39.88058  ?  110 THR A HG21 1 
ATOM   469  H HG22 . THR A 1 29  ? -13.98472 -4.25471  -24.15530 1.000 39.88058  ?  110 THR A HG22 1 
ATOM   470  H HG23 . THR A 1 29  ? -12.39877 -3.50353  -24.41572 1.000 39.88058  ?  110 THR A HG23 1 
ATOM   471  N N    . ASP A 1 30  ? -11.80585 -6.49567  -28.18240 1.000 40.55730  ?  111 ASP A N    1 
ATOM   472  C CA   . ASP A 1 30  ? -11.83538 -7.33021  -29.37008 1.000 32.20182  ?  111 ASP A CA   1 
ATOM   473  C C    . ASP A 1 30  ? -11.67220 -8.76978  -28.89515 1.000 46.13339  ?  111 ASP A C    1 
ATOM   474  O O    . ASP A 1 30  ? -10.67578 -9.07912  -28.21881 1.000 38.64889  ?  111 ASP A O    1 
ATOM   475  C CB   . ASP A 1 30  ? -10.70850 -6.89889  -30.30497 1.000 38.97365  ?  111 ASP A CB   1 
ATOM   476  C CG   . ASP A 1 30  ? -10.56525 -7.80199  -31.51703 1.000 46.98843  ?  111 ASP A CG   1 
ATOM   477  O OD1  . ASP A 1 30  ? -11.22163 -8.85864  -31.55452 1.000 56.90672  ?  111 ASP A OD1  1 
ATOM   478  O OD2  . ASP A 1 30  ? -9.79689  -7.44191  -32.43744 1.000 53.45792  -1 111 ASP A OD2  1 
ATOM   479  H H    A ASP A 1 30  ? -10.98273 -5.89883  -28.10088 0.090 48.66876  ?  111 ASP A H    1 
ATOM   480  D D    B ASP A 1 30  ? -10.98239 -5.89918  -28.10173 0.910 48.66876  ?  111 ASP A D    1 
ATOM   481  H HA   . ASP A 1 30  ? -12.76513 -7.24171  -29.93207 1.000 38.64218  ?  111 ASP A HA   1 
ATOM   482  H HB2  . ASP A 1 30  ? -10.91059 -5.88861  -30.66078 1.000 46.76838  ?  111 ASP A HB2  1 
ATOM   483  H HB3  . ASP A 1 30  ? -9.76633  -6.91974  -29.75726 1.000 46.76838  ?  111 ASP A HB3  1 
ATOM   484  N N    . PRO A 1 31  ? -12.62883 -9.66590  -29.17380 1.000 58.57265  ?  112 PRO A N    1 
ATOM   485  C CA   . PRO A 1 31  ? -12.54628 -11.01862 -28.59802 1.000 59.89639  ?  112 PRO A CA   1 
ATOM   486  C C    . PRO A 1 31  ? -11.39964 -11.84768 -29.13962 1.000 55.14924  ?  112 PRO A C    1 
ATOM   487  O O    . PRO A 1 31  ? -10.93670 -12.76316 -28.44590 1.000 45.57391  ?  112 PRO A O    1 
ATOM   488  C CB   . PRO A 1 31  ? -13.90564 -11.65301 -28.94659 1.000 50.20265  ?  112 PRO A CB   1 
ATOM   489  C CG   . PRO A 1 31  ? -14.78959 -10.52261 -29.33293 1.000 62.52092  ?  112 PRO A CG   1 
ATOM   490  C CD   . PRO A 1 31  ? -13.89373 -9.46000  -29.89978 1.000 59.25505  ?  112 PRO A CD   1 
ATOM   491  H HA   . PRO A 1 31  ? -12.45262 -10.93837 -27.51502 1.000 71.87567  ?  112 PRO A HA   1 
ATOM   492  H HB2  . PRO A 1 31  ? -13.78431 -12.35045 -29.77541 1.000 60.24318  ?  112 PRO A HB2  1 
ATOM   493  H HB3  . PRO A 1 31  ? -14.30230 -12.17453 -28.07552 1.000 60.24318  ?  112 PRO A HB3  1 
ATOM   494  H HG2  . PRO A 1 31  ? -15.50711 -10.85921 -30.08123 1.000 75.02511  ?  112 PRO A HG2  1 
ATOM   495  H HG3  . PRO A 1 31  ? -15.31501 -10.15237 -28.45261 1.000 75.02511  ?  112 PRO A HG3  1 
ATOM   496  H HD2  . PRO A 1 31  ? -13.75394 -9.60073  -30.97158 1.000 71.10606  ?  112 PRO A HD2  1 
ATOM   497  H HD3  . PRO A 1 31  ? -14.29701 -8.46652  -29.70369 1.000 71.10606  ?  112 PRO A HD3  1 
ATOM   498  N N    . THR A 1 32  ? -10.94909 -11.58775 -30.36650 1.000 43.08809  ?  113 THR A N    1 
ATOM   499  C CA   . THR A 1 32  ? -9.80277  -12.32413 -30.88279 1.000 46.88454  ?  113 THR A CA   1 
ATOM   500  C C    . THR A 1 32  ? -8.49828  -11.84402 -30.24219 1.000 50.51051  ?  113 THR A C    1 
ATOM   501  O O    . THR A 1 32  ? -7.64154  -12.66132 -29.88150 1.000 36.64375  ?  113 THR A O    1 
ATOM   502  C CB   . THR A 1 32  ? -9.74434  -12.26754 -32.41748 1.000 44.88957  ?  113 THR A CB   1 
ATOM   503  O OG1  . THR A 1 32  ? -8.38930  -12.44032 -32.84463 1.000 56.27649  ?  113 THR A OG1  1 
ATOM   504  C CG2  . THR A 1 32  ? -10.26559 -10.95987 -32.98728 1.000 45.22638  ?  113 THR A CG2  1 
ATOM   505  H H    A THR A 1 32  ? -11.34369 -10.89663 -31.00450 0.000 51.70571  ?  113 THR A H    1 
ATOM   506  D D    B THR A 1 32  ? -11.34227 -10.89713 -31.00592 1.000 51.70571  ?  113 THR A D    1 
ATOM   507  H HA   . THR A 1 32  ? -9.92472  -13.37730 -30.62967 1.000 56.26144  ?  113 THR A HA   1 
ATOM   508  H HB   . THR A 1 32  ? -10.38413 -13.06166 -32.80239 1.000 53.86749  ?  113 THR A HB   1 
ATOM   509  H HG1  A THR A 1 32  ? -7.81898  -11.75670 -32.43500 0.250 67.53179  ?  113 THR A HG1  1 
ATOM   510  D DG1  B THR A 1 32  ? -7.82513  -11.73572 -32.46298 0.750 67.53179  ?  113 THR A DG1  1 
ATOM   511  H HG21 . THR A 1 32  ? -11.32120 -10.84122 -32.74293 1.000 54.27166  ?  113 THR A HG21 1 
ATOM   512  H HG22 . THR A 1 32  ? -9.70895  -10.12206 -32.56735 1.000 54.27166  ?  113 THR A HG22 1 
ATOM   513  H HG23 . THR A 1 32  ? -10.15048 -10.95331 -34.07116 1.000 54.27166  ?  113 THR A HG23 1 
ATOM   514  N N    . LEU A 1 33  ? -8.32928  -10.53107 -30.07650 1.000 38.64413  ?  114 LEU A N    1 
ATOM   515  C CA   . LEU A 1 33  ? -7.13670  -10.04149 -29.39925 1.000 35.78939  ?  114 LEU A CA   1 
ATOM   516  C C    . LEU A 1 33  ? -7.12550  -10.49697 -27.95132 1.000 31.66716  ?  114 LEU A C    1 
ATOM   517  O O    . LEU A 1 33  ? -6.06194  -10.79422 -27.38819 1.000 28.93052  ?  114 LEU A O    1 
ATOM   518  C CB   . LEU A 1 33  ? -7.08633  -8.51845  -29.49054 1.000 35.21806  ?  114 LEU A CB   1 
ATOM   519  C CG   . LEU A 1 33  ? -5.69629  -7.89266  -29.57475 1.000 40.02623  ?  114 LEU A CG   1 
ATOM   520  C CD1  . LEU A 1 33  ? -4.96704  -8.29240  -30.86313 1.000 42.27646  ?  114 LEU A CD1  1 
ATOM   521  C CD2  . LEU A 1 33  ? -5.82935  -6.37943  -29.47288 1.000 43.82255  ?  114 LEU A CD2  1 
ATOM   522  H H    A LEU A 1 33  ? -8.97799  -9.80884  -30.38947 0.170 46.37296  ?  114 LEU A H    1 
ATOM   523  D D    B LEU A 1 33  ? -8.97640  -9.80699  -30.38849 0.830 46.37296  ?  114 LEU A D    1 
ATOM   524  H HA   . LEU A 1 33  ? -6.24604  -10.43652 -29.88790 1.000 42.94727  ?  114 LEU A HA   1 
ATOM   525  H HB2  . LEU A 1 33  ? -7.63046  -8.21456  -30.38478 1.000 42.26168  ?  114 LEU A HB2  1 
ATOM   526  H HB3  . LEU A 1 33  ? -7.56968  -8.10978  -28.60314 1.000 42.26168  ?  114 LEU A HB3  1 
ATOM   527  H HG   . LEU A 1 33  ? -5.08529  -8.25953  -28.75002 1.000 48.03148  ?  114 LEU A HG   1 
ATOM   528  H HD11 . LEU A 1 33  ? -5.68257  -8.74364  -31.55051 1.000 50.73175  ?  114 LEU A HD11 1 
ATOM   529  H HD12 . LEU A 1 33  ? -4.52928  -7.40181  -31.31405 1.000 50.73175  ?  114 LEU A HD12 1 
ATOM   530  H HD13 . LEU A 1 33  ? -4.18298  -9.00926  -30.61929 1.000 50.73175  ?  114 LEU A HD13 1 
ATOM   531  H HD21 . LEU A 1 33  ? -6.18779  -5.98977  -30.42566 1.000 52.58706  ?  114 LEU A HD21 1 
ATOM   532  H HD22 . LEU A 1 33  ? -6.53936  -6.13808  -28.68184 1.000 52.58706  ?  114 LEU A HD22 1 
ATOM   533  H HD23 . LEU A 1 33  ? -4.85396  -5.95231  -29.23991 1.000 52.58706  ?  114 LEU A HD23 1 
ATOM   534  N N    . SER A 1 34  ? -8.29887  -10.55149 -27.32051 1.000 27.57337  ?  115 SER A N    1 
ATOM   535  C CA   . SER A 1 34  ? -8.37384  -11.01650 -25.94053 1.000 28.80103  ?  115 SER A CA   1 
ATOM   536  C C    . SER A 1 34  ? -7.88673  -12.45972 -25.83849 1.000 34.33376  ?  115 SER A C    1 
ATOM   537  O O    . SER A 1 34  ? -7.19381  -12.82056 -24.88626 1.000 26.27638  ?  115 SER A O    1 
ATOM   538  C CB   . SER A 1 34  ? -9.81364  -10.88269 -25.43020 1.000 27.35294  ?  115 SER A CB   1 
ATOM   539  O OG   . SER A 1 34  ? -9.92658  -11.19778 -24.05774 1.000 30.95565  ?  115 SER A OG   1 
ATOM   540  H H    A SER A 1 34  ? -9.19504  -10.28637 -27.72915 0.140 33.08805  ?  115 SER A H    1 
ATOM   541  D D    B SER A 1 34  ? -9.19627  -10.28699 -27.72685 0.860 33.08805  ?  115 SER A D    1 
ATOM   542  H HA   . SER A 1 34  ? -7.73817  -10.39868 -25.30624 1.000 34.56123  ?  115 SER A HA   1 
ATOM   543  H HB2  . SER A 1 34  ? -10.14209 -9.85416  -25.57970 1.000 32.82353  ?  115 SER A HB2  1 
ATOM   544  H HB3  . SER A 1 34  ? -10.44893 -11.56307 -25.99728 1.000 32.82353  ?  115 SER A HB3  1 
ATOM   545  N N    . SER A 1 35  ? -8.24102  -13.30171 -26.81211 1.000 28.56735  ?  116 SER A N    1 
ATOM   546  C CA   . SER A 1 35  ? -7.80963  -14.70314 -26.78098 1.000 43.21697  ?  116 SER A CA   1 
ATOM   547  C C    . SER A 1 35  ? -6.29940  -14.80890 -26.90249 1.000 32.44108  ?  116 SER A C    1 
ATOM   548  O O    . SER A 1 35  ? -5.65742  -15.57981 -26.17836 1.000 27.87227  ?  116 SER A O    1 
ATOM   549  C CB   . SER A 1 35  ? -8.45963  -15.48416 -27.92455 1.000 37.53601  ?  116 SER A CB   1 
ATOM   550  O OG   . SER A 1 35  ? -9.79812  -15.82698 -27.60396 1.000 71.51499  ?  116 SER A OG   1 
ATOM   551  H H    A SER A 1 35  ? -8.81309  -13.05279 -27.61906 0.010 34.28082  ?  116 SER A H    1 
ATOM   552  D D    B SER A 1 35  ? -8.81290  -13.05530 -27.61996 0.990 34.28082  ?  116 SER A D    1 
ATOM   553  H HA   . SER A 1 35  ? -8.12712  -15.13847 -25.83347 1.000 51.86036  ?  116 SER A HA   1 
ATOM   554  H HB2  . SER A 1 35  ? -8.45680  -14.86662 -28.82273 1.000 45.04322  ?  116 SER A HB2  1 
ATOM   555  H HB3  . SER A 1 35  ? -7.89117  -16.39778 -28.09849 1.000 45.04322  ?  116 SER A HB3  1 
ATOM   556  N N    . LYS A 1 36  ? -5.72743  -14.05341 -27.83519 1.000 26.25130  ?  117 LYS A N    1 
ATOM   557  C CA   . LYS A 1 36  ? -4.27898  -14.02564 -28.00981 1.000 32.08151  ?  117 LYS A CA   1 
ATOM   558  C C    . LYS A 1 36  ? -3.58913  -13.51139 -26.74644 1.000 22.18475  ?  117 LYS A C    1 
ATOM   559  O O    . LYS A 1 36  ? -2.59594  -14.09630 -26.28595 1.000 21.76907  ?  117 LYS A O    1 
ATOM   560  C CB   . LYS A 1 36  ? -3.94998  -13.18502 -29.24771 1.000 26.05908  ?  117 LYS A CB   1 
ATOM   561  C CG   . LYS A 1 36  ? -4.04978  -13.98750 -30.54126 1.000 32.34544  ?  117 LYS A CG   1 
ATOM   562  C CD   . LYS A 1 36  ? -4.16112  -13.12953 -31.81190 1.000 48.54904  ?  117 LYS A CD   1 
ATOM   563  C CE   . LYS A 1 36  ? -2.83519  -12.46222 -32.20058 1.000 81.83365  ?  117 LYS A CE   1 
ATOM   564  N NZ   . LYS A 1 36  ? -2.22947  -12.96662 -33.48111 1.000 49.74957  ?  117 LYS A NZ   1 
ATOM   565  H H    A LYS A 1 36  ? -6.23511  -13.45150 -28.48356 0.000 31.50156  ?  117 LYS A H    1 
ATOM   566  D D    B LYS A 1 36  ? -6.23274  -13.45073 -28.48469 1.000 31.50156  ?  117 LYS A D    1 
ATOM   567  H HA   . LYS A 1 36  ? -3.89061  -15.02893 -28.18496 1.000 38.49782  ?  117 LYS A HA   1 
ATOM   568  H HB2  . LYS A 1 36  ? -4.65179  -12.35334 -29.30991 1.000 31.27089  ?  117 LYS A HB2  1 
ATOM   569  H HB3  . LYS A 1 36  ? -2.93117  -12.80741 -29.16097 1.000 31.27089  ?  117 LYS A HB3  1 
ATOM   570  H HG2  . LYS A 1 36  ? -3.15687  -14.60504 -30.63845 1.000 38.81453  ?  117 LYS A HG2  1 
ATOM   571  H HG3  . LYS A 1 36  ? -4.93656  -14.61942 -30.49221 1.000 38.81453  ?  117 LYS A HG3  1 
ATOM   572  H HD2  . LYS A 1 36  ? -4.47405  -13.76319 -32.64174 1.000 58.25885  ?  117 LYS A HD2  1 
ATOM   573  H HD3  . LYS A 1 36  ? -4.89691  -12.34273 -31.64556 1.000 58.25885  ?  117 LYS A HD3  1 
ATOM   574  H HE2  . LYS A 1 36  ? -3.00670  -11.39230 -32.31864 1.000 98.20038  ?  117 LYS A HE2  1 
ATOM   575  H HE3  . LYS A 1 36  ? -2.11170  -12.63820 -31.40453 1.000 98.20038  ?  117 LYS A HE3  1 
ATOM   576  N N    . ALA A 1 37  ? -4.13708  -12.47929 -26.12666 1.000 22.04001  ?  118 ALA A N    1 
ATOM   577  C CA   . ALA A 1 37  ? -3.55807  -11.95261 -24.89715 1.000 20.71730  ?  118 ALA A CA   1 
ATOM   578  C C    . ALA A 1 37  ? -3.61313  -12.98074 -23.77968 1.000 25.90791  ?  118 ALA A C    1 
ATOM   579  O O    . ALA A 1 37  ? -2.65761  -13.12738 -23.00409 1.000 20.12308  ?  118 ALA A O    1 
ATOM   580  C CB   . ALA A 1 37  ? -4.27751  -10.66216 -24.49254 1.000 20.61229  ?  118 ALA A CB   1 
ATOM   581  H H    A ALA A 1 37  ? -4.97295  -11.98749 -26.44265 0.630 26.44801  ?  118 ALA A H    1 
ATOM   582  D D    B ALA A 1 37  ? -4.97277  -11.98582 -26.44053 0.370 26.44801  ?  118 ALA A D    1 
ATOM   583  H HA   . ALA A 1 37  ? -2.51010  -11.70935 -25.07231 1.000 24.86076  ?  118 ALA A HA   1 
ATOM   584  H HB1  . ALA A 1 37  ? -3.69907  -10.16196 -23.71581 1.000 24.73474  ?  118 ALA A HB1  1 
ATOM   585  H HB2  . ALA A 1 37  ? -4.36448  -10.01560 -25.36576 1.000 24.73474  ?  118 ALA A HB2  1 
ATOM   586  H HB3  . ALA A 1 37  ? -5.26897  -10.91207 -24.11486 1.000 24.73474  ?  118 ALA A HB3  1 
ATOM   587  N N    . ALA A 1 38  ? -4.72516  -13.70822 -23.66939 1.000 23.43874  ?  119 ALA A N    1 
ATOM   588  C CA   . ALA A 1 38  ? -4.84221  -14.71464 -22.62463 1.000 24.22447  ?  119 ALA A CA   1 
ATOM   589  C C    . ALA A 1 38  ? -3.74628  -15.75941 -22.72874 1.000 18.50822  ?  119 ALA A C    1 
ATOM   590  O O    . ALA A 1 38  ? -3.25932  -16.24860 -21.70876 1.000 23.27784  ?  119 ALA A O    1 
ATOM   591  C CB   . ALA A 1 38  ? -6.20824  -15.39806 -22.68833 1.000 23.83877  ?  119 ALA A CB   1 
ATOM   592  H H    A ALA A 1 38  ? -5.54179  -13.62467 -24.27482 0.480 28.12649  ?  119 ALA A H    1 
ATOM   593  D D    B ALA A 1 38  ? -5.54301  -13.62661 -24.27343 0.520 28.12649  ?  119 ALA A D    1 
ATOM   594  H HA   . ALA A 1 38  ? -4.75588  -14.21369 -21.66043 1.000 29.06936  ?  119 ALA A HA   1 
ATOM   595  H HB1  . ALA A 1 38  ? -6.95299  -14.74577 -22.23229 1.000 28.60653  ?  119 ALA A HB1  1 
ATOM   596  H HB2  . ALA A 1 38  ? -6.46452  -15.58240 -23.73161 1.000 28.60653  ?  119 ALA A HB2  1 
ATOM   597  H HB3  . ALA A 1 38  ? -6.15849  -16.34193 -22.14543 1.000 28.60653  ?  119 ALA A HB3  1 
ATOM   598  N N    . SER A 1 39  ? -3.33377  -16.07484 -23.93485 1.000 19.57987  ?  120 SER A N    1 
ATOM   599  C CA   . SER A 1 39  ? -2.36382  -17.13641 -24.15133 1.000 20.04136  ?  120 SER A CA   1 
ATOM   600  C C    . SER A 1 39  ? -0.96419  -16.75864 -23.64841 1.000 17.51908  ?  120 SER A C    1 
ATOM   601  O O    . SER A 1 39  ? -0.12124  -17.65422 -23.46103 1.000 19.93228  ?  120 SER A O    1 
ATOM   602  C CB   . SER A 1 39  ? -2.35105  -17.48671 -25.62864 1.000 19.35552  ?  120 SER A CB   1 
ATOM   603  O OG   . SER A 1 39  ? -1.57268  -16.58010 -26.36782 1.000 22.21757  ?  120 SER A OG   1 
ATOM   604  H H    A SER A 1 39  ? -3.64796  -15.61785 -24.79091 0.000 23.49585  ?  120 SER A H    1 
ATOM   605  D D    B SER A 1 39  ? -3.64686  -15.61898 -24.79191 1.000 23.49585  ?  120 SER A D    1 
ATOM   606  H HA   . SER A 1 39  ? -2.65336  -18.03040 -23.59901 1.000 24.04963  ?  120 SER A HA   1 
ATOM   607  H HB2  . SER A 1 39  ? -1.93503  -18.48696 -25.74917 1.000 23.22663  ?  120 SER A HB2  1 
ATOM   608  H HB3  . SER A 1 39  ? -3.37367  -17.46043 -26.00502 1.000 23.22663  ?  120 SER A HB3  1 
ATOM   609  H HG   A SER A 1 39  ? -1.88306  -15.66430 -26.20853 0.060 26.66108  ?  120 SER A HG   1 
ATOM   610  D DG   B SER A 1 39  ? -1.90574  -15.66781 -26.23672 0.940 26.66108  ?  120 SER A DG   1 
ATOM   611  N N    . VAL A 1 40  ? -0.70788  -15.47633 -23.40420 1.000 17.23750  ?  121 VAL A N    1 
ATOM   612  C CA   . VAL A 1 40  ? 0.59129   -15.04737 -22.86432 1.000 17.11447  ?  121 VAL A CA   1 
ATOM   613  C C    . VAL A 1 40  ? 0.84348   -15.63598 -21.49500 1.000 18.85502  ?  121 VAL A C    1 
ATOM   614  O O    . VAL A 1 40  ? 2.00057   -15.83637 -21.10780 1.000 18.38663  ?  121 VAL A O    1 
ATOM   615  C CB   . VAL A 1 40  ? 0.64461   -13.51171 -22.86033 1.000 15.89141  ?  121 VAL A CB   1 
ATOM   616  C CG1  . VAL A 1 40  ? 1.88905   -12.99288 -22.10782 1.000 19.48578  ?  121 VAL A CG1  1 
ATOM   617  C CG2  . VAL A 1 40  ? 0.60621   -12.99062 -24.27205 1.000 20.07273  ?  121 VAL A CG2  1 
ATOM   618  H H    A VAL A 1 40  ? -1.36546  -14.71330 -23.56478 1.000 20.68500  ?  121 VAL A H    1 
ATOM   619  D D    B VAL A 1 40  ? -1.36386  -14.71177 -23.56400 0.000 20.68500  ?  121 VAL A D    1 
ATOM   620  H HA   . VAL A 1 40  ? 1.38843   -15.42063 -23.50723 1.000 20.53736  ?  121 VAL A HA   1 
ATOM   621  H HB   . VAL A 1 40  ? -0.22858  -13.13218 -22.32967 1.000 19.06969  ?  121 VAL A HB   1 
ATOM   622  H HG11 . VAL A 1 40  ? 1.91412   -13.43894 -21.11358 1.000 23.38294  ?  121 VAL A HG11 1 
ATOM   623  H HG12 . VAL A 1 40  ? 2.78313   -13.27436 -22.66414 1.000 23.38294  ?  121 VAL A HG12 1 
ATOM   624  H HG13 . VAL A 1 40  ? 1.82795   -11.90761 -22.02687 1.000 23.38294  ?  121 VAL A HG13 1 
ATOM   625  H HG21 . VAL A 1 40  ? 1.60353   -13.06593 -24.70537 1.000 24.08727  ?  121 VAL A HG21 1 
ATOM   626  H HG22 . VAL A 1 40  ? -0.09710  -13.58828 -24.85193 1.000 24.08727  ?  121 VAL A HG22 1 
ATOM   627  H HG23 . VAL A 1 40  ? 0.28503   -11.94911 -24.25728 1.000 24.08727  ?  121 VAL A HG23 1 
ATOM   628  N N    . ALA A 1 41  ? -0.20895  -15.99655 -20.75902 1.000 18.11133  ?  122 ALA A N    1 
ATOM   629  C CA   . ALA A 1 41  ? -0.01152  -16.53573 -19.42801 1.000 16.89727  ?  122 ALA A CA   1 
ATOM   630  C C    . ALA A 1 41  ? 0.67062   -17.88989 -19.46975 1.000 16.38110  ?  122 ALA A C    1 
ATOM   631  O O    . ALA A 1 41  ? 1.15379   -18.35542 -18.43643 1.000 19.50576  ?  122 ALA A O    1 
ATOM   632  C CB   . ALA A 1 41  ? -1.35982  -16.65500 -18.70796 1.000 19.95724  ?  122 ALA A CB   1 
ATOM   633  H H    A ALA A 1 41  ? -1.18274  -15.92685 -21.05447 0.990 21.73360  ?  122 ALA A H    1 
ATOM   634  D D    B ALA A 1 41  ? -1.18333  -15.92762 -21.05268 0.010 21.73360  ?  122 ALA A D    1 
ATOM   635  H HA   . ALA A 1 41  ? 0.61632   -15.85300 -18.85548 1.000 20.27672  ?  122 ALA A HA   1 
ATOM   636  H HB1  . ALA A 1 41  ? -1.87364  -15.69488 -18.75545 1.000 23.94869  ?  122 ALA A HB1  1 
ATOM   637  H HB2  . ALA A 1 41  ? -1.95833  -17.42162 -19.20007 1.000 23.94869  ?  122 ALA A HB2  1 
ATOM   638  H HB3  . ALA A 1 41  ? -1.18372  -16.93133 -17.66838 1.000 23.94869  ?  122 ALA A HB3  1 
ATOM   639  N N    . ASN A 1 42  ? 0.70028   -18.54588 -20.62428 1.000 15.33366  ?  123 ASN A N    1 
ATOM   640  C CA   . ASN A 1 42  ? 1.36188   -19.82278 -20.78421 1.000 16.08673  ?  123 ASN A CA   1 
ATOM   641  C C    . ASN A 1 42  ? 2.80449   -19.70808 -21.30985 1.000 16.66321  ?  123 ASN A C    1 
ATOM   642  O O    . ASN A 1 42  ? 3.41830   -20.73086 -21.62434 1.000 17.50827  ?  123 ASN A O    1 
ATOM   643  C CB   . ASN A 1 42  ? 0.55433   -20.71792 -21.73986 1.000 19.35571  ?  123 ASN A CB   1 
ATOM   644  C CG   . ASN A 1 42  ? -0.84320  -21.01369 -21.22310 1.000 27.34294  ?  123 ASN A CG   1 
ATOM   645  O OD1  . ASN A 1 42  ? -1.04212  -21.20798 -20.02791 1.000 35.67401  ?  123 ASN A OD1  1 
ATOM   646  N ND2  . ASN A 1 42  ? -1.81697  -21.04044 -22.13668 1.000 31.16560  ?  123 ASN A ND2  1 
ATOM   647  H H    A ASN A 1 42  ? 0.26377   -18.20556 -21.48104 0.000 18.40039  ?  123 ASN A H    1 
ATOM   648  D D    B ASN A 1 42  ? 0.26326   -18.20424 -21.48026 1.000 18.40039  ?  123 ASN A D    1 
ATOM   649  H HA   . ASN A 1 42  ? 1.40183   -20.29753 -19.80384 1.000 19.30408  ?  123 ASN A HA   1 
ATOM   650  H HB2  . ASN A 1 42  ? 0.45904   -20.21558 -22.70250 1.000 23.22685  ?  123 ASN A HB2  1 
ATOM   651  H HB3  . ASN A 1 42  ? 1.07603   -21.66681 -21.86454 1.000 23.22685  ?  123 ASN A HB3  1 
ATOM   652  N N    . ILE A 1 43  ? 3.34113   -18.50438 -21.41204 1.000 14.97744  ?  124 ILE A N    1 
ATOM   653  C CA   . ILE A 1 43  ? 4.71953   -18.27947 -21.86359 1.000 14.67989  ?  124 ILE A CA   1 
ATOM   654  C C    . ILE A 1 43  ? 5.57202   -18.03882 -20.62195 1.000 15.13499  ?  124 ILE A C    1 
ATOM   655  O O    . ILE A 1 43  ? 5.25442   -17.13563 -19.84471 1.000 15.19088  ?  124 ILE A O    1 
ATOM   656  C CB   . ILE A 1 43  ? 4.79609   -17.07807 -22.80782 1.000 13.08463  ?  124 ILE A CB   1 
ATOM   657  C CG1  . ILE A 1 43  ? 3.88357   -17.31379 -24.01518 1.000 16.76776  ?  124 ILE A CG1  1 
ATOM   658  C CG2  . ILE A 1 43  ? 6.27392   -16.84124 -23.23122 1.000 16.87482  ?  124 ILE A CG2  1 
ATOM   659  C CD1  . ILE A 1 43  ? 3.68100   -16.14112 -24.87566 1.000 21.59839  ?  124 ILE A CD1  1 
ATOM   660  H H    A ILE A 1 43  ? 2.84367   -17.64284 -21.18691 0.870 17.97293  ?  124 ILE A H    1 
ATOM   661  D D    B ILE A 1 43  ? 2.84165   -17.64416 -21.18631 0.130 17.97293  ?  124 ILE A D    1 
ATOM   662  H HA   . ILE A 1 43  ? 5.09395   -19.15899 -22.38739 1.000 17.61586  ?  124 ILE A HA   1 
ATOM   663  H HB   . ILE A 1 43  ? 4.44644   -16.18007 -22.29847 1.000 15.70156  ?  124 ILE A HB   1 
ATOM   664  H HG12 . ILE A 1 43  ? 4.32129   -18.09960 -24.63082 1.000 20.12131  ?  124 ILE A HG12 1 
ATOM   665  H HG13 . ILE A 1 43  ? 2.90441   -17.62637 -23.65234 1.000 20.12131  ?  124 ILE A HG13 1 
ATOM   666  H HG21 . ILE A 1 43  ? 6.33614   -15.91234 -23.79812 1.000 20.24979  ?  124 ILE A HG21 1 
ATOM   667  H HG22 . ILE A 1 43  ? 6.89278   -16.77285 -22.33656 1.000 20.24979  ?  124 ILE A HG22 1 
ATOM   668  H HG23 . ILE A 1 43  ? 6.60433   -17.67643 -23.84879 1.000 20.24979  ?  124 ILE A HG23 1 
ATOM   669  H HD11 . ILE A 1 43  ? 4.62073   -15.89837 -25.37172 1.000 25.91807  ?  124 ILE A HD11 1 
ATOM   670  H HD12 . ILE A 1 43  ? 2.91784   -16.37354 -25.61840 1.000 25.91807  ?  124 ILE A HD12 1 
ATOM   671  H HD13 . ILE A 1 43  ? 3.35757   -15.30131 -24.26067 1.000 25.91807  ?  124 ILE A HD13 1 
ATOM   672  N N    . PRO A 1 44  ? 6.64830   -18.79531 -20.41204 1.000 13.46047  ?  125 PRO A N    1 
ATOM   673  C CA   . PRO A 1 44  ? 7.42793   -18.64552 -19.17149 1.000 12.64792  ?  125 PRO A CA   1 
ATOM   674  C C    . PRO A 1 44  ? 8.18886   -17.32535 -19.09127 1.000 12.74758  ?  125 PRO A C    1 
ATOM   675  O O    . PRO A 1 44  ? 8.81651   -16.89019 -20.05924 1.000 13.60907  ?  125 PRO A O    1 
ATOM   676  C CB   . PRO A 1 44  ? 8.39106   -19.83461 -19.20851 1.000 16.30869  ?  125 PRO A CB   1 
ATOM   677  C CG   . PRO A 1 44  ? 8.40354   -20.29814 -20.53558 1.000 22.25681  ?  125 PRO A CG   1 
ATOM   678  C CD   . PRO A 1 44  ? 7.10753   -19.93613 -21.20981 1.000 15.38660  ?  125 PRO A CD   1 
ATOM   679  H HA   . PRO A 1 44  ? 6.75989   -18.71805 -18.31326 1.000 15.17750  ?  125 PRO A HA   1 
ATOM   680  H HB2  . PRO A 1 44  ? 9.38592   -19.50667 -18.90718 1.000 19.57043  ?  125 PRO A HB2  1 
ATOM   681  H HB3  . PRO A 1 44  ? 8.03468   -20.61276 -18.53355 1.000 19.57043  ?  125 PRO A HB3  1 
ATOM   682  H HG2  . PRO A 1 44  ? 9.23712   -19.83240 -21.06125 1.000 26.70817  ?  125 PRO A HG2  1 
ATOM   683  H HG3  . PRO A 1 44  ? 8.52657   -21.38114 -20.52698 1.000 26.70817  ?  125 PRO A HG3  1 
ATOM   684  H HD2  . PRO A 1 44  ? 7.27276   -19.64759 -22.24786 1.000 18.46392  ?  125 PRO A HD2  1 
ATOM   685  H HD3  . PRO A 1 44  ? 6.39629   -20.76064 -21.16073 1.000 18.46392  ?  125 PRO A HD3  1 
ATOM   686  N N    . THR A 1 45  ? 8.12424   -16.70947 -17.91841 1.000 12.27431  ?  126 THR A N    1 
ATOM   687  C CA   . THR A 1 45  ? 8.83684   -15.47403 -17.59708 1.000 12.07028  ?  126 THR A CA   1 
ATOM   688  C C    . THR A 1 45  ? 9.61127   -15.68897 -16.30784 1.000 11.85303  ?  126 THR A C    1 
ATOM   689  O O    . THR A 1 45  ? 9.43010   -16.68825 -15.60730 1.000 14.01579  ?  126 THR A O    1 
ATOM   690  C CB   . THR A 1 45  ? 7.85850   -14.28059 -17.42182 1.000 12.73553  ?  126 THR A CB   1 
ATOM   691  O OG1  . THR A 1 45  ? 6.89798   -14.57074 -16.38159 1.000 14.97231  ?  126 THR A OG1  1 
ATOM   692  C CG2  . THR A 1 45  ? 7.10731   -13.97921 -18.67982 1.000 15.67528  ?  126 THR A CG2  1 
ATOM   693  H H    A THR A 1 45  ? 7.56519   -17.05318 -17.13756 0.180 14.72917  ?  126 THR A H    1 
ATOM   694  D D    B THR A 1 45  ? 7.56455   -17.05485 -17.13876 0.820 14.72917  ?  126 THR A D    1 
ATOM   695  H HA   . THR A 1 45  ? 9.53039   -15.23358 -18.40286 1.000 14.48434  ?  126 THR A HA   1 
ATOM   696  H HB   . THR A 1 45  ? 8.45087   -13.40445 -17.15804 1.000 15.28264  ?  126 THR A HB   1 
ATOM   697  H HG1  A THR A 1 45  ? 6.44904   -15.42172 -16.56779 0.000 17.96677  ?  126 THR A HG1  1 
ATOM   698  D DG1  B THR A 1 45  ? 6.38899   -15.37628 -16.61057 1.000 17.96677  ?  126 THR A DG1  1 
ATOM   699  H HG21 . THR A 1 45  ? 6.78998   -14.90698 -19.15589 1.000 18.81033  ?  126 THR A HG21 1 
ATOM   700  H HG22 . THR A 1 45  ? 6.22640   -13.37859 -18.45321 1.000 18.81033  ?  126 THR A HG22 1 
ATOM   701  H HG23 . THR A 1 45  ? 7.74393   -13.42674 -19.37090 1.000 18.81033  ?  126 THR A HG23 1 
ATOM   702  N N    . PHE A 1 46  ? 10.48672  -14.72490 -15.99414 1.000 11.11008  ?  127 PHE A N    1 
ATOM   703  C CA   . PHE A 1 46  ? 11.21614  -14.71300 -14.72961 1.000 10.80190  ?  127 PHE A CA   1 
ATOM   704  C C    . PHE A 1 46  ? 10.44761  -13.93456 -13.68313 1.000 12.28533  ?  127 PHE A C    1 
ATOM   705  O O    . PHE A 1 46  ? 9.83078   -12.91720 -13.97044 1.000 13.31049  ?  127 PHE A O    1 
ATOM   706  C CB   . PHE A 1 46  ? 12.59243  -14.06238 -14.92837 1.000 11.48788  ?  127 PHE A CB   1 
ATOM   707  C CG   . PHE A 1 46  ? 13.60873  -15.00539 -15.46577 1.000 10.69975  ?  127 PHE A CG   1 
ATOM   708  C CD1  . PHE A 1 46  ? 13.48522  -15.55191 -16.72655 1.000 12.71114  ?  127 PHE A CD1  1 
ATOM   709  C CD2  . PHE A 1 46  ? 14.67969  -15.39103 -14.68639 1.000 11.29779  ?  127 PHE A CD2  1 
ATOM   710  C CE1  . PHE A 1 46  ? 14.41739  -16.46679 -17.19247 1.000 12.79098  ?  127 PHE A CE1  1 
ATOM   711  C CE2  . PHE A 1 46  ? 15.62749  -16.27752 -15.19074 1.000 12.64543  ?  127 PHE A CE2  1 
ATOM   712  C CZ   . PHE A 1 46  ? 15.47603  -16.80304 -16.43328 1.000 12.63736  ?  127 PHE A CZ   1 
ATOM   713  H H    A PHE A 1 46  ? 10.70952  -13.93687 -16.60223 0.960 13.33210  ?  127 PHE A H    1 
ATOM   714  D D    B PHE A 1 46  ? 10.70907  -13.93711 -16.60270 0.040 13.33210  ?  127 PHE A D    1 
ATOM   715  H HA   . PHE A 1 46  ? 11.34920  -15.73460 -14.37361 1.000 12.96227  ?  127 PHE A HA   1 
ATOM   716  H HB2  . PHE A 1 46  ? 12.49474  -13.23613 -15.63254 1.000 13.78546  ?  127 PHE A HB2  1 
ATOM   717  H HB3  . PHE A 1 46  ? 12.95116  -13.69301 -13.96765 1.000 13.78546  ?  127 PHE A HB3  1 
ATOM   718  H HD1  . PHE A 1 46  ? 12.65573  -15.26484 -17.35579 1.000 15.25337  ?  127 PHE A HD1  1 
ATOM   719  H HD2  . PHE A 1 46  ? 14.78311  -15.00460 -13.68321 1.000 13.55735  ?  127 PHE A HD2  1 
ATOM   720  H HE1  . PHE A 1 46  ? 14.29305  -16.91127 -18.16888 1.000 15.34918  ?  127 PHE A HE1  1 
ATOM   721  H HE2  . PHE A 1 46  ? 16.48494  -16.54765 -14.59224 1.000 15.17451  ?  127 PHE A HE2  1 
ATOM   722  H HZ   . PHE A 1 46  ? 16.21087  -17.49624 -16.81522 1.000 15.16483  ?  127 PHE A HZ   1 
ATOM   723  N N    . THR A 1 47  ? 10.52578  -14.38987 -12.43819 1.000 10.94180  ?  128 THR A N    1 
ATOM   724  C CA   . THR A 1 47  ? 9.94581   -13.68706 -11.29602 1.000 11.82952  ?  128 THR A CA   1 
ATOM   725  C C    . THR A 1 47  ? 11.01689  -12.86383 -10.60827 1.000 11.34872  ?  128 THR A C    1 
ATOM   726  O O    . THR A 1 47  ? 12.08670  -13.38475 -10.26232 1.000 12.88508  ?  128 THR A O    1 
ATOM   727  C CB   . THR A 1 47  ? 9.41936   -14.73093 -10.30327 1.000 14.85738  ?  128 THR A CB   1 
ATOM   728  O OG1  . THR A 1 47  ? 8.32596   -15.44847 -10.90120 1.000 18.13073  ?  128 THR A OG1  1 
ATOM   729  C CG2  . THR A 1 47  ? 8.97757   -14.06529 -9.00988  1.000 20.82582  ?  128 THR A CG2  1 
ATOM   730  H H    A THR A 1 47  ? 10.99324  -15.25958 -12.18227 1.000 13.13015  ?  128 THR A H    1 
ATOM   731  D D    B THR A 1 47  ? 10.99368  -15.25988 -12.18410 0.000 13.13015  ?  128 THR A D    1 
ATOM   732  H HA   . THR A 1 47  ? 9.14824   -13.01980 -11.62275 1.000 14.19542  ?  128 THR A HA   1 
ATOM   733  H HB   . THR A 1 47  ? 10.20954  -15.43859 -10.05241 1.000 17.82886  ?  128 THR A HB   1 
ATOM   734  H HG1  A THR A 1 47  ? 7.89244   -14.89242 -11.58184 0.310 21.75687  ?  128 THR A HG1  1 
ATOM   735  D DG1  B THR A 1 47  ? 7.92462   -14.91240 -11.61671 0.690 21.75687  ?  128 THR A DG1  1 
ATOM   736  H HG21 . THR A 1 47  ? 8.42381   -14.77520 -8.39549  1.000 24.99098  ?  128 THR A HG21 1 
ATOM   737  H HG22 . THR A 1 47  ? 9.84798   -13.71887 -8.45267  1.000 24.99098  ?  128 THR A HG22 1 
ATOM   738  H HG23 . THR A 1 47  ? 8.33590   -13.21210 -9.22996  1.000 24.99098  ?  128 THR A HG23 1 
ATOM   739  N N    . TRP A 1 48  ? 10.75911  -11.59963 -10.38949 1.000 11.10819  ?  129 TRP A N    1 
ATOM   740  C CA   . TRP A 1 48  ? 11.76324  -10.68700 -9.84787  1.000 11.18890  ?  129 TRP A CA   1 
ATOM   741  C C    . TRP A 1 48  ? 11.63423  -10.58483 -8.33834  1.000 12.37373  ?  129 TRP A C    1 
ATOM   742  O O    . TRP A 1 48  ? 10.58401  -10.18447 -7.82771  1.000 14.38638  ?  129 TRP A O    1 
ATOM   743  C CB   . TRP A 1 48  ? 11.61060  -9.30845  -10.49625 1.000 11.55950  ?  129 TRP A CB   1 
ATOM   744  C CG   . TRP A 1 48  ? 11.99735  -9.27390  -11.94746 1.000 10.95931  ?  129 TRP A CG   1 
ATOM   745  C CD1  . TRP A 1 48  ? 11.46122  -10.01601 -12.97211 1.000 12.37414  ?  129 TRP A CD1  1 
ATOM   746  C CD2  . TRP A 1 48  ? 12.99619  -8.42930  -12.52449 1.000 10.66447  ?  129 TRP A CD2  1 
ATOM   747  N NE1  . TRP A 1 48  ? 12.09336  -9.68914  -14.14122 1.000 12.03628  ?  129 TRP A NE1  1 
ATOM   748  C CE2  . TRP A 1 48  ? 13.02330  -8.70574  -13.91121 1.000 10.77822  ?  129 TRP A CE2  1 
ATOM   749  C CE3  . TRP A 1 48  ? 13.85448  -7.46408  -12.01378 1.000 12.67590  ?  129 TRP A CE3  1 
ATOM   750  C CZ2  . TRP A 1 48  ? 13.90279  -8.05047  -14.79890 1.000 12.46315  ?  129 TRP A CZ2  1 
ATOM   751  C CZ3  . TRP A 1 48  ? 14.72722  -6.80744  -12.87552 1.000 14.11019  ?  129 TRP A CZ3  1 
ATOM   752  C CH2  . TRP A 1 48  ? 14.74311  -7.10046  -14.27634 1.000 13.52266  ?  129 TRP A CH2  1 
ATOM   753  H H    A TRP A 1 48  ? 9.85767   -11.15990 -10.57507 0.130 13.32982  ?  129 TRP A H    1 
ATOM   754  D D    B TRP A 1 48  ? 9.85697   -11.16162 -10.57571 0.870 13.32982  ?  129 TRP A D    1 
ATOM   755  H HA   . TRP A 1 48  ? 12.75716  -11.08301 -10.05619 1.000 13.42668  ?  129 TRP A HA   1 
ATOM   756  H HB2  . TRP A 1 48  ? 10.56756  -9.00056  -10.42299 1.000 13.87140  ?  129 TRP A HB2  1 
ATOM   757  H HB3  . TRP A 1 48  ? 12.24664  -8.59969  -9.96596  1.000 13.87140  ?  129 TRP A HB3  1 
ATOM   758  H HD1  . TRP A 1 48  ? 10.66759  -10.74151 -12.87106 1.000 14.84897  ?  129 TRP A HD1  1 
ATOM   759  H HE1  A TRP A 1 48  ? 11.90192  -10.11331 -15.04887 0.850 14.44354  ?  129 TRP A HE1  1 
ATOM   760  D DE1  B TRP A 1 48  ? 11.90192  -10.11331 -15.04887 0.150 14.44354  ?  129 TRP A DE1  1 
ATOM   761  H HE3  . TRP A 1 48  ? 13.84447  -7.22616  -10.96036 1.000 15.21109  ?  129 TRP A HE3  1 
ATOM   762  H HZ2  . TRP A 1 48  ? 13.91399  -8.28840  -15.85230 1.000 14.95578  ?  129 TRP A HZ2  1 
ATOM   763  H HZ3  . TRP A 1 48  ? 15.40407  -6.06413  -12.48084 1.000 16.93223  ?  129 TRP A HZ3  1 
ATOM   764  H HH2  . TRP A 1 48  ? 15.42203  -6.56945  -14.92710 1.000 16.22720  ?  129 TRP A HH2  1 
ATOM   765  N N    . LEU A 1 49  ? 12.69349  -10.92397 -7.64196  1.000 11.50096  ?  130 LEU A N    1 
ATOM   766  C CA   . LEU A 1 49  ? 12.77942  -10.76429 -6.18605  1.000 11.07600  ?  130 LEU A CA   1 
ATOM   767  C C    . LEU A 1 49  ? 13.44594  -9.42310  -5.91140  1.000 11.63082  ?  130 LEU A C    1 
ATOM   768  O O    . LEU A 1 49  ? 14.63395  -9.31273  -5.58959  1.000 13.94043  ?  130 LEU A O    1 
ATOM   769  C CB   . LEU A 1 49  ? 13.55439  -11.92841 -5.57452  1.000 13.43821  ?  130 LEU A CB   1 
ATOM   770  C CG   . LEU A 1 49  ? 12.94018  -13.28325 -5.85334  1.000 17.42355  ?  130 LEU A CG   1 
ATOM   771  C CD1  . LEU A 1 49  ? 13.82267  -14.37244 -5.21758  1.000 21.06039  ?  130 LEU A CD1  1 
ATOM   772  C CD2  . LEU A 1 49  ? 11.50554  -13.39694 -5.39138  1.000 24.88938  ?  130 LEU A CD2  1 
ATOM   773  H H    A LEU A 1 49  ? 13.53731  -11.32330 -8.05294  1.000 13.80115  ?  130 LEU A H    1 
ATOM   774  D D    B LEU A 1 49  ? 13.53702  -11.32327 -8.05356  0.000 13.80115  ?  130 LEU A D    1 
ATOM   775  H HA   . LEU A 1 49  ? 11.78420  -10.76949 -5.74151  1.000 13.29120  ?  130 LEU A HA   1 
ATOM   776  H HB2  . LEU A 1 49  ? 14.56453  -11.92953 -5.98406  1.000 16.12585  ?  130 LEU A HB2  1 
ATOM   777  H HB3  . LEU A 1 49  ? 13.59060  -11.79479 -4.49335  1.000 16.12585  ?  130 LEU A HB3  1 
ATOM   778  H HG   . LEU A 1 49  ? 12.89947  -13.42819 -6.93290  1.000 20.90826  ?  130 LEU A HG   1 
ATOM   779  H HD11 . LEU A 1 49  ? 13.68249  -14.35665 -4.13675  1.000 25.27247  ?  130 LEU A HD11 1 
ATOM   780  H HD12 . LEU A 1 49  ? 13.52996  -15.34379 -5.61620  1.000 25.27247  ?  130 LEU A HD12 1 
ATOM   781  H HD13 . LEU A 1 49  ? 14.86594  -14.17021 -5.46008  1.000 25.27247  ?  130 LEU A HD13 1 
ATOM   782  H HD21 . LEU A 1 49  ? 10.84435  -13.17427 -6.22885  1.000 29.86726  ?  130 LEU A HD21 1 
ATOM   783  H HD22 . LEU A 1 49  ? 11.32650  -14.41172 -5.03606  1.000 29.86726  ?  130 LEU A HD22 1 
ATOM   784  H HD23 . LEU A 1 49  ? 11.33527  -12.68489 -4.58386  1.000 29.86726  ?  130 LEU A HD23 1 
ATOM   785  N N    . ASP A 1 50  ? 12.66268  -8.36482  -6.12122  1.000 13.73177  ?  131 ASP A N    1 
ATOM   786  C CA   . ASP A 1 50  ? 13.16375  -7.00735  -6.07418  1.000 13.11940  ?  131 ASP A CA   1 
ATOM   787  C C    . ASP A 1 50  ? 12.97162  -6.35946  -4.70476  1.000 14.37768  ?  131 ASP A C    1 
ATOM   788  O O    . ASP A 1 50  ? 13.30989  -5.19276  -4.52943  1.000 17.13582  ?  131 ASP A O    1 
ATOM   789  C CB   . ASP A 1 50  ? 12.60388  -6.17528  -7.22114  1.000 15.82365  ?  131 ASP A CB   1 
ATOM   790  C CG   . ASP A 1 50  ? 11.11857  -6.02202  -7.17012  1.000 24.23658  ?  131 ASP A CG   1 
ATOM   791  O OD1  . ASP A 1 50  ? 10.42203  -6.85997  -6.58125  1.000 20.77841  ?  131 ASP A OD1  1 
ATOM   792  O OD2  . ASP A 1 50  ? 10.64268  -5.00329  -7.70914  1.000 41.70702  -1 131 ASP A OD2  1 
ATOM   793  H H    A ASP A 1 50  ? 11.66575  -8.42652  -6.32792  0.000 16.47812  ?  131 ASP A H    1 
ATOM   794  D D    B ASP A 1 50  ? 11.66584  -8.42828  -6.32783  1.000 16.47812  ?  131 ASP A D    1 
ATOM   795  H HA   . ASP A 1 50  ? 14.24011  -7.01781  -6.24575  1.000 15.74327  ?  131 ASP A HA   1 
ATOM   796  H HB2  . ASP A 1 50  ? 13.04441  -5.17904  -7.18213  1.000 18.98838  ?  131 ASP A HB2  1 
ATOM   797  H HB3  . ASP A 1 50  ? 12.85801  -6.65860  -8.16450  1.000 18.98838  ?  131 ASP A HB3  1 
ATOM   798  N N    . SER A 1 51  ? 12.54437  -7.13345  -3.72417  1.000 15.52712  ?  132 SER A N    1 
ATOM   799  C CA   . SER A 1 51  ? 12.43276  -6.66319  -2.33398  1.000 15.89244  ?  132 SER A CA   1 
ATOM   800  C C    . SER A 1 51  ? 12.36493  -7.88867  -1.44308  1.000 14.27439  ?  132 SER A C    1 
ATOM   801  O O    . SER A 1 51  ? 11.96255  -8.97866  -1.86623  1.000 15.79335  ?  132 SER A O    1 
ATOM   802  C CB   . SER A 1 51  ? 11.20945  -5.76630  -2.11787  1.000 20.67874  ?  132 SER A CB   1 
ATOM   803  O OG   . SER A 1 51  ? 10.02620  -6.49370  -2.29170  1.000 30.08339  ?  132 SER A OG   1 
ATOM   804  H H    A SER A 1 51  ? 12.26106  -8.10549  -3.84778  0.670 18.63254  ?  132 SER A H    1 
ATOM   805  D D    B SER A 1 51  ? 12.26103  -8.10550  -3.84763  0.330 18.63254  ?  132 SER A D    1 
ATOM   806  H HA   . SER A 1 51  ? 13.31313  -6.07515  -2.07464  1.000 19.07092  ?  132 SER A HA   1 
ATOM   807  H HB2  . SER A 1 51  ? 11.23580  -5.36729  -1.10387  1.000 24.81449  ?  132 SER A HB2  1 
ATOM   808  H HB3  . SER A 1 51  ? 11.23465  -4.95047  -2.84030  1.000 24.81449  ?  132 SER A HB3  1 
ATOM   809  N N    . VAL A 1 52  ? 12.73323  -7.69733  -0.16657  1.000 16.28783  ?  133 VAL A N    1 
ATOM   810  C CA   . VAL A 1 52  ? 12.64448  -8.80281  0.79520   1.000 13.95768  ?  133 VAL A CA   1 
ATOM   811  C C    . VAL A 1 52  ? 11.20182  -9.23691  0.97914   1.000 15.92570  ?  133 VAL A C    1 
ATOM   812  O O    . VAL A 1 52  ? 10.94429  -10.37920 1.35253   1.000 17.67850  ?  133 VAL A O    1 
ATOM   813  C CB   . VAL A 1 52  ? 13.25211  -8.46438  2.18143   1.000 22.89782  ?  133 VAL A CB   1 
ATOM   814  C CG1  . VAL A 1 52  ? 14.69878  -8.25648  2.10375   1.000 25.88569  ?  133 VAL A CG1  1 
ATOM   815  C CG2  . VAL A 1 52  ? 12.60410  -7.22170  2.74629   1.000 33.27725  ?  133 VAL A CG2  1 
ATOM   816  H H    A VAL A 1 52  ? 13.08432  -6.82016  0.21776   0.000 19.54540  ?  133 VAL A H    1 
ATOM   817  D D    B VAL A 1 52  ? 13.08453  -6.82115  0.21981   1.000 19.54540  ?  133 VAL A D    1 
ATOM   818  H HA   . VAL A 1 52  ? 13.23956  -9.60902  0.36624   1.000 16.74921  ?  133 VAL A HA   1 
ATOM   819  H HB   . VAL A 1 52  ? 13.06420  -9.31194  2.84055   1.000 27.47739  ?  133 VAL A HB   1 
ATOM   820  H HG11 . VAL A 1 52  ? 15.05167  -8.57976  1.12443   1.000 31.06283  ?  133 VAL A HG11 1 
ATOM   821  H HG12 . VAL A 1 52  ? 14.91315  -7.19715  2.24501   1.000 31.06283  ?  133 VAL A HG12 1 
ATOM   822  H HG13 . VAL A 1 52  ? 15.18381  -8.84131  2.88529   1.000 31.06283  ?  133 VAL A HG13 1 
ATOM   823  H HG21 . VAL A 1 52  ? 12.93335  -7.08682  3.77658   1.000 39.93270  ?  133 VAL A HG21 1 
ATOM   824  H HG22 . VAL A 1 52  ? 12.90132  -6.36214  2.14553   1.000 39.93270  ?  133 VAL A HG22 1 
ATOM   825  H HG23 . VAL A 1 52  ? 11.52106  -7.34062  2.71472   1.000 39.93270  ?  133 VAL A HG23 1 
ATOM   826  N N    . ALA A 1 53  ? 10.24644  -8.33185  0.76232   1.000 16.69271  ?  134 ALA A N    1 
ATOM   827  C CA   . ALA A 1 53  ? 8.84464   -8.69431  0.94846   1.000 19.95821  ?  134 ALA A CA   1 
ATOM   828  C C    . ALA A 1 53  ? 8.41216   -9.79966  0.00066   1.000 23.37951  ?  134 ALA A C    1 
ATOM   829  O O    . ALA A 1 53  ? 7.42395   -10.47491 0.28279   1.000 24.25744  ?  134 ALA A O    1 
ATOM   830  C CB   . ALA A 1 53  ? 7.95116   -7.46180  0.79414   1.000 24.15227  ?  134 ALA A CB   1 
ATOM   831  H H    A ALA A 1 53  ? 10.40650  -7.36900  0.46619   0.000 20.03125  ?  134 ALA A H    1 
ATOM   832  D D    B ALA A 1 53  ? 10.40449  -7.36866  0.46621   1.000 20.03125  ?  134 ALA A D    1 
ATOM   833  H HA   . ALA A 1 53  ? 8.70612   -9.06260  1.96496   1.000 23.94985  ?  134 ALA A HA   1 
ATOM   834  H HB1  . ALA A 1 53  ? 8.11187   -6.79834  1.64389   1.000 28.98272  ?  134 ALA A HB1  1 
ATOM   835  H HB2  . ALA A 1 53  ? 8.21070   -6.94907  -0.13206  1.000 28.98272  ?  134 ALA A HB2  1 
ATOM   836  H HB3  . ALA A 1 53  ? 6.90923   -7.78045  0.76320   1.000 28.98272  ?  134 ALA A HB3  1 
ATOM   837  N N    . LYS A 1 54  ? 9.13930   -10.03809 -1.09723  1.000 17.57614  ?  135 LYS A N    1 
ATOM   838  C CA   . LYS A 1 54  ? 8.74565   -11.08515 -2.02776  1.000 18.08388  ?  135 LYS A CA   1 
ATOM   839  C C    . LYS A 1 54  ? 9.29371   -12.47088 -1.68039  1.000 16.35401  ?  135 LYS A C    1 
ATOM   840  O O    . LYS A 1 54  ? 8.93201   -13.45686 -2.35757  1.000 17.54153  ?  135 LYS A O    1 
ATOM   841  C CB   . LYS A 1 54  ? 9.14820   -10.66129 -3.44061  1.000 20.01114  ?  135 LYS A CB   1 
ATOM   842  C CG   . LYS A 1 54  ? 8.47224   -9.33338  -3.83162  1.000 30.01667  ?  135 LYS A CG   1 
ATOM   843  C CD   . LYS A 1 54  ? 8.02876   -9.30208  -5.25215  1.000 28.40424  ?  135 LYS A CD   1 
ATOM   844  C CE   . LYS A 1 54  ? 7.58451   -7.91851  -5.73009  1.000 29.75961  ?  135 LYS A CE   1 
ATOM   845  N NZ   . LYS A 1 54  ? 7.85049   -7.79580  -7.20804  1.000 31.70546  ?  135 LYS A NZ   1 
ATOM   846  H H    A LYS A 1 54  ? 9.98513   -9.53044  -1.35656  0.230 21.09136  ?  135 LYS A H    1 
ATOM   847  D D    B LYS A 1 54  ? 9.98508   -9.53007  -1.35603  0.770 21.09136  ?  135 LYS A D    1 
ATOM   848  H HA   . LYS A 1 54  ? 7.66192   -11.20073 -2.01104  1.000 21.70066  ?  135 LYS A HA   1 
ATOM   849  H HB2  . LYS A 1 54  ? 10.22882  -10.52538 -3.48412  1.000 24.01336  ?  135 LYS A HB2  1 
ATOM   850  H HB3  . LYS A 1 54  ? 8.84008   -11.42862 -4.15079  1.000 24.01336  ?  135 LYS A HB3  1 
ATOM   851  H HG2  . LYS A 1 54  ? 7.59447   -9.18381  -3.20294  1.000 36.02000  ?  135 LYS A HG2  1 
ATOM   852  H HG3  . LYS A 1 54  ? 9.18029   -8.51803  -3.68337  1.000 36.02000  ?  135 LYS A HG3  1 
ATOM   853  H HD2  . LYS A 1 54  ? 8.85634   -9.62167  -5.88546  1.000 34.08509  ?  135 LYS A HD2  1 
ATOM   854  H HD3  . LYS A 1 54  ? 7.18434   -9.98094  -5.37138  1.000 34.08509  ?  135 LYS A HD3  1 
ATOM   855  H HE2  . LYS A 1 54  ? 6.51708   -7.78958  -5.55103  1.000 35.71153  ?  135 LYS A HE2  1 
ATOM   856  H HE3  . LYS A 1 54  ? 8.14660   -7.14663  -5.20440  1.000 35.71153  ?  135 LYS A HE3  1 
ATOM   857  N N    . ILE A 1 55  ? 10.17292  -12.58201 -0.69112  1.000 14.15827  ?  136 ILE A N    1 
ATOM   858  C CA   . ILE A 1 55  ? 10.76601  -13.87272 -0.38596  1.000 15.11816  ?  136 ILE A CA   1 
ATOM   859  C C    . ILE A 1 55  ? 9.72321   -14.90634 0.02120   1.000 17.28772  ?  136 ILE A C    1 
ATOM   860  O O    . ILE A 1 55  ? 9.79877   -16.04526 -0.45243  1.000 17.21490  ?  136 ILE A O    1 
ATOM   861  C CB   . ILE A 1 55  ? 11.92668  -13.71562 0.59892   1.000 16.79259  ?  136 ILE A CB   1 
ATOM   862  C CG1  . ILE A 1 55  ? 13.03967  -12.91845 -0.09903  1.000 17.09213  ?  136 ILE A CG1  1 
ATOM   863  C CG2  . ILE A 1 55  ? 12.44261  -15.05768 1.02636   1.000 19.70739  ?  136 ILE A CG2  1 
ATOM   864  C CD1  . ILE A 1 55  ? 14.16101  -12.44202 0.83269   1.000 23.82946  ?  136 ILE A CD1  1 
ATOM   865  H H    A ILE A 1 55  ? 10.48733  -11.81485 -0.09697  0.980 16.98992  ?  136 ILE A H    1 
ATOM   866  D D    B ILE A 1 55  ? 10.48895  -11.81659 -0.09560  0.020 16.98992  ?  136 ILE A D    1 
ATOM   867  H HA   . ILE A 1 55  ? 11.21462  -14.24330 -1.30766  1.000 18.14179  ?  136 ILE A HA   1 
ATOM   868  H HB   . ILE A 1 55  ? 11.58396  -13.18903 1.48961   1.000 20.15110  ?  136 ILE A HB   1 
ATOM   869  H HG12 . ILE A 1 55  ? 13.49271  -13.55043 -0.86286  1.000 20.51056  ?  136 ILE A HG12 1 
ATOM   870  H HG13 . ILE A 1 55  ? 12.59739  -12.03531 -0.56006  1.000 20.51056  ?  136 ILE A HG13 1 
ATOM   871  H HG21 . ILE A 1 55  ? 11.71943  -15.51787 1.69967   1.000 23.64887  ?  136 ILE A HG21 1 
ATOM   872  H HG22 . ILE A 1 55  ? 12.57915  -15.68286 0.14398   1.000 23.64887  ?  136 ILE A HG22 1 
ATOM   873  H HG23 . ILE A 1 55  ? 13.39541  -14.92481 1.53882   1.000 23.64887  ?  136 ILE A HG23 1 
ATOM   874  H HD11 . ILE A 1 55  ? 14.91218  -13.22761 0.91454   1.000 28.59535  ?  136 ILE A HD11 1 
ATOM   875  H HD12 . ILE A 1 55  ? 14.60990  -11.54053 0.41567   1.000 28.59535  ?  136 ILE A HD12 1 
ATOM   876  H HD13 . ILE A 1 55  ? 13.73929  -12.22724 1.81459   1.000 28.59535  ?  136 ILE A HD13 1 
ATOM   877  N N    . PRO A 1 56  ? 8.71292   -14.59119 0.83730   1.000 17.45519  ?  137 PRO A N    1 
ATOM   878  C CA   . PRO A 1 56  ? 7.69019   -15.62555 1.11633   1.000 19.78040  ?  137 PRO A CA   1 
ATOM   879  C C    . PRO A 1 56  ? 6.97802   -16.13622 -0.11835  1.000 16.26648  ?  137 PRO A C    1 
ATOM   880  O O    . PRO A 1 56  ? 6.65617   -17.32828 -0.19968  1.000 17.22320  ?  137 PRO A O    1 
ATOM   881  C CB   . PRO A 1 56  ? 6.74608   -14.91208 2.09568   1.000 19.42291  ?  137 PRO A CB   1 
ATOM   882  C CG   . PRO A 1 56  ? 7.65628   -13.88662 2.76707   1.000 22.31217  ?  137 PRO A CG   1 
ATOM   883  C CD   . PRO A 1 56  ? 8.51489   -13.37678 1.63440   1.000 17.15146  ?  137 PRO A CD   1 
ATOM   884  H HA   . PRO A 1 56  ? 8.14495   -16.47845 1.62017   1.000 23.73648  ?  137 PRO A HA   1 
ATOM   885  H HB2  . PRO A 1 56  ? 5.93262   -14.42847 1.55485   1.000 23.30749  ?  137 PRO A HB2  1 
ATOM   886  H HB3  . PRO A 1 56  ? 6.34322   -15.62075 2.81927   1.000 23.30749  ?  137 PRO A HB3  1 
ATOM   887  H HG2  . PRO A 1 56  ? 7.06264   -13.08416 3.20497   1.000 26.77460  ?  137 PRO A HG2  1 
ATOM   888  H HG3  . PRO A 1 56  ? 8.26137   -14.36548 3.53691   1.000 26.77460  ?  137 PRO A HG3  1 
ATOM   889  H HD2  . PRO A 1 56  ? 7.99555   -12.60909 1.06078   1.000 20.58175  ?  137 PRO A HD2  1 
ATOM   890  H HD3  . PRO A 1 56  ? 9.46412   -12.98828 2.00334   1.000 20.58175  ?  137 PRO A HD3  1 
ATOM   891  N N    . ASP A 1 57  ? 6.77543   -15.28683 -1.11810  1.000 16.28754  ?  138 ASP A N    1 
ATOM   892  C CA   . ASP A 1 57  ? 6.15993   -15.73560 -2.35433  1.000 17.58728  ?  138 ASP A CA   1 
ATOM   893  C C    . ASP A 1 57  ? 7.02598   -16.75784 -3.06636  1.000 16.69402  ?  138 ASP A C    1 
ATOM   894  O O    . ASP A 1 57  ? 6.51547   -17.73421 -3.61838  1.000 15.41518  ?  138 ASP A O    1 
ATOM   895  C CB   . ASP A 1 57  ? 5.85734   -14.54451 -3.26885  1.000 19.98129  ?  138 ASP A CB   1 
ATOM   896  C CG   . ASP A 1 57  ? 4.74165   -13.65364 -2.72560  1.000 29.40861  ?  138 ASP A CG   1 
ATOM   897  O OD1  . ASP A 1 57  ? 3.72281   -14.21829 -2.27403  1.000 35.77587  ?  138 ASP A OD1  1 
ATOM   898  O OD2  . ASP A 1 57  ? 4.89332   -12.41420 -2.76514  1.000 50.25248  -1 138 ASP A OD2  1 
ATOM   899  H H    A ASP A 1 57  ? 7.02270   -14.29738 -1.10255  0.000 19.54505  ?  138 ASP A H    1 
ATOM   900  D D    B ASP A 1 57  ? 7.02174   -14.29710 -1.10505  1.000 19.54505  ?  138 ASP A D    1 
ATOM   901  H HA   . ASP A 1 57  ? 5.21043   -16.21300 -2.11219  1.000 21.10474  ?  138 ASP A HA   1 
ATOM   902  H HB2  . ASP A 1 57  ? 6.75615   -13.93615 -3.36952  1.000 23.97754  ?  138 ASP A HB2  1 
ATOM   903  H HB3  . ASP A 1 57  ? 5.54724   -14.91592 -4.24558  1.000 23.97754  ?  138 ASP A HB3  1 
ATOM   904  N N    . LEU A 1 58  ? 8.34710   -16.56863 -3.04280  1.000 14.99015  ?  139 LEU A N    1 
ATOM   905  C CA   . LEU A 1 58  ? 9.23968   -17.56355 -3.63202  1.000 16.37113  ?  139 LEU A CA   1 
ATOM   906  C C    . LEU A 1 58  ? 9.00878   -18.94002 -3.00873  1.000 13.78193  ?  139 LEU A C    1 
ATOM   907  O O    . LEU A 1 58  ? 9.00355   -19.96604 -3.69851  1.000 14.50242  ?  139 LEU A O    1 
ATOM   908  C CB   . LEU A 1 58  ? 10.69998  -17.13833 -3.43383  1.000 17.56133  ?  139 LEU A CB   1 
ATOM   909  C CG   . LEU A 1 58  ? 11.74554  -18.20342 -3.79517  1.000 17.84990  ?  139 LEU A CG   1 
ATOM   910  C CD1  . LEU A 1 58  ? 11.69693  -18.49282 -5.28032  1.000 19.57405  ?  139 LEU A CD1  1 
ATOM   911  C CD2  . LEU A 1 58  ? 13.16375  -17.78248 -3.36364  1.000 20.62531  ?  139 LEU A CD2  1 
ATOM   912  H H    A LEU A 1 58  ? 8.81623   -15.76001 -2.63482  0.930 17.98818  ?  139 LEU A H    1 
ATOM   913  D D    B LEU A 1 58  ? 8.81832   -15.76091 -2.63543  0.070 17.98818  ?  139 LEU A D    1 
ATOM   914  H HA   . LEU A 1 58  ? 9.03745   -17.62569 -4.70129  1.000 19.64535  ?  139 LEU A HA   1 
ATOM   915  H HB2  . LEU A 1 58  ? 10.89180  -16.26674 -4.05964  1.000 21.07359  ?  139 LEU A HB2  1 
ATOM   916  H HB3  . LEU A 1 58  ? 10.84368  -16.88244 -2.38408  1.000 21.07359  ?  139 LEU A HB3  1 
ATOM   917  H HG   . LEU A 1 58  ? 11.51100  -19.11942 -3.25292  1.000 21.41988  ?  139 LEU A HG   1 
ATOM   918  H HD11 . LEU A 1 58  ? 11.81201  -17.55750 -5.82807  1.000 23.48885  ?  139 LEU A HD11 1 
ATOM   919  H HD12 . LEU A 1 58  ? 12.50763  -19.17524 -5.53561  1.000 23.48885  ?  139 LEU A HD12 1 
ATOM   920  H HD13 . LEU A 1 58  ? 10.73697  -18.94923 -5.52169  1.000 23.48885  ?  139 LEU A HD13 1 
ATOM   921  H HD21 . LEU A 1 58  ? 13.44745  -16.88153 -3.90761  1.000 24.75038  ?  139 LEU A HD21 1 
ATOM   922  H HD22 . LEU A 1 58  ? 13.16461  -17.58520 -2.29165  1.000 24.75038  ?  139 LEU A HD22 1 
ATOM   923  H HD23 . LEU A 1 58  ? 13.85896  -18.58990 -3.59355  1.000 24.75038  ?  139 LEU A HD23 1 
ATOM   924  N N    . GLY A 1 59  ? 8.89275   -18.99002 -1.67469  1.000 14.05388  ?  140 GLY A N    1 
ATOM   925  C CA   . GLY A 1 59  ? 8.60516   -20.25758 -1.01185  1.000 14.84062  ?  140 GLY A CA   1 
ATOM   926  C C    . GLY A 1 59  ? 7.35247   -20.92337 -1.53884  1.000 13.05937  ?  140 GLY A C    1 
ATOM   927  O O    . GLY A 1 59  ? 7.34418   -22.12527 -1.78331  1.000 14.49074  ?  140 GLY A O    1 
ATOM   928  H H    A GLY A 1 59  ? 8.99020   -18.19183 -1.04716  0.730 16.86466  ?  140 GLY A H    1 
ATOM   929  D D    B GLY A 1 59  ? 8.98965   -18.19371 -1.04469  0.270 16.86466  ?  140 GLY A D    1 
ATOM   930  H HA2  . GLY A 1 59  ? 9.44284   -20.93884 -1.16108  1.000 17.80875  ?  140 GLY A HA2  1 
ATOM   931  H HA3  . GLY A 1 59  ? 8.47578   -20.08286 0.05625   1.000 17.80875  ?  140 GLY A HA3  1 
ATOM   932  N N    . THR A 1 60  ? 6.29460   -20.14211 -1.79317  1.000 12.37428  ?  141 THR A N    1 
ATOM   933  C CA   . THR A 1 60  ? 5.07173   -20.73891 -2.33487  1.000 13.15140  ?  141 THR A CA   1 
ATOM   934  C C    . THR A 1 60  ? 5.28848   -21.23567 -3.75594  1.000 14.64013  ?  141 THR A C    1 
ATOM   935  O O    . THR A 1 60  ? 4.74677   -22.27390 -4.14445  1.000 14.58915  ?  141 THR A O    1 
ATOM   936  C CB   . THR A 1 60  ? 3.83389   -19.81757 -2.26812  1.000 15.29496  ?  141 THR A CB   1 
ATOM   937  O OG1  . THR A 1 60  ? 3.94268   -18.74179 -3.19336  1.000 18.09655  ?  141 THR A OG1  1 
ATOM   938  C CG2  . THR A 1 60  ? 3.62201   -19.30798 -0.83668  1.000 16.11260  ?  141 THR A CG2  1 
ATOM   939  H H    A THR A 1 60  ? 6.25542   -19.13430 -1.64093  0.430 14.84914  ?  141 THR A H    1 
ATOM   940  D D    B THR A 1 60  ? 6.25296   -19.13427 -1.64182  0.570 14.84914  ?  141 THR A D    1 
ATOM   941  H HA   . THR A 1 60  ? 4.83400   -21.57852 -1.68169  1.000 15.78168  ?  141 THR A HA   1 
ATOM   942  H HB   . THR A 1 60  ? 2.94738   -20.38640 -2.54854  1.000 18.35395  ?  141 THR A HB   1 
ATOM   943  H HG1  A THR A 1 60  ? 4.65669   -18.13105 -2.91484  0.150 21.71586  ?  141 THR A HG1  1 
ATOM   944  D DG1  B THR A 1 60  ? 4.72476   -18.19203 -2.97773  0.850 21.71586  ?  141 THR A DG1  1 
ATOM   945  H HG21 . THR A 1 60  ? 3.72962   -20.12971 -0.12867  1.000 19.33512  ?  141 THR A HG21 1 
ATOM   946  H HG22 . THR A 1 60  ? 4.35864   -18.53973 -0.60159  1.000 19.33512  ?  141 THR A HG22 1 
ATOM   947  H HG23 . THR A 1 60  ? 2.62331   -18.88301 -0.73625  1.000 19.33512  ?  141 THR A HG23 1 
ATOM   948  N N    . TYR A 1 61  ? 6.09817   -20.52074 -4.56077  1.000 13.34662  ?  142 TYR A N    1 
ATOM   949  C CA   . TYR A 1 61  ? 6.31601   -20.97106 -5.93164  1.000 13.39050  ?  142 TYR A CA   1 
ATOM   950  C C    . TYR A 1 61  ? 7.09426   -22.28051 -5.96104  1.000 12.14247  ?  142 TYR A C    1 
ATOM   951  O O    . TYR A 1 61  ? 6.77556   -23.18058 -6.73198  1.000 13.66930  ?  142 TYR A O    1 
ATOM   952  C CB   . TYR A 1 61  ? 7.07278   -19.91439 -6.71172  1.000 14.56220  ?  142 TYR A CB   1 
ATOM   953  C CG   . TYR A 1 61  ? 6.34837   -18.61000 -6.87240  1.000 17.15240  ?  142 TYR A CG   1 
ATOM   954  C CD1  . TYR A 1 61  ? 4.98754   -18.49038 -6.61271  1.000 17.02154  ?  142 TYR A CD1  1 
ATOM   955  C CD2  . TYR A 1 61  ? 7.03173   -17.47214 -7.25864  1.000 27.54987  ?  142 TYR A CD2  1 
ATOM   956  C CE1  . TYR A 1 61  ? 4.32830   -17.27356 -6.77161  1.000 21.23394  ?  142 TYR A CE1  1 
ATOM   957  C CE2  . TYR A 1 61  ? 6.38389   -16.25026 -7.41034  1.000 37.90909  ?  142 TYR A CE2  1 
ATOM   958  C CZ   . TYR A 1 61  ? 5.03592   -16.15543 -7.16700  1.000 34.52842  ?  142 TYR A CZ   1 
ATOM   959  O OH   . TYR A 1 61  ? 4.37670   -14.94822 -7.30031  1.000 38.69880  ?  142 TYR A OH   1 
ATOM   960  H H    A TYR A 1 61  ? 6.59045   -19.66707 -4.29748  1.000 16.01595  ?  142 TYR A H    1 
ATOM   961  D D    B TYR A 1 61  ? 6.59147   -19.66693 -4.29986  0.000 16.01595  ?  142 TYR A D    1 
ATOM   962  H HA   . TYR A 1 61  ? 5.34593   -21.12665 -6.40371  1.000 16.06860  ?  142 TYR A HA   1 
ATOM   963  H HB2  . TYR A 1 61  ? 8.00947   -19.70724 -6.19424  1.000 17.47464  ?  142 TYR A HB2  1 
ATOM   964  H HB3  . TYR A 1 61  ? 7.27616   -20.30125 -7.71026  1.000 17.47464  ?  142 TYR A HB3  1 
ATOM   965  H HD1  . TYR A 1 61  ? 4.43222   -19.35569 -6.28215  1.000 20.42585  ?  142 TYR A HD1  1 
ATOM   966  H HD2  . TYR A 1 61  ? 8.09342   -17.53308 -7.44705  1.000 33.05984  ?  142 TYR A HD2  1 
ATOM   967  H HE1  . TYR A 1 61  ? 3.26658   -17.20474 -6.58607  1.000 25.48073  ?  142 TYR A HE1  1 
ATOM   968  H HE2  . TYR A 1 61  ? 6.94043   -15.37770 -7.71904  1.000 45.49091  ?  142 TYR A HE2  1 
ATOM   969  N N    . LEU A 1 62  ? 8.12666   -22.39886 -5.12825  1.000 11.86752  ?  143 LEU A N    1 
ATOM   970  C CA   . LEU A 1 62  ? 8.89051   -23.63429 -5.06683  1.000 12.70662  ?  143 LEU A CA   1 
ATOM   971  C C    . LEU A 1 62  ? 8.01613   -24.80738 -4.64008  1.000 13.84993  ?  143 LEU A C    1 
ATOM   972  O O    . LEU A 1 62  ? 8.12350   -25.90395 -5.19570  1.000 14.16176  ?  143 LEU A O    1 
ATOM   973  C CB   . LEU A 1 62  ? 10.07523  -23.49764 -4.11130  1.000 12.20080  ?  143 LEU A CB   1 
ATOM   974  C CG   . LEU A 1 62  ? 11.11563  -22.44777 -4.52520  1.000 13.82065  ?  143 LEU A CG   1 
ATOM   975  C CD1  . LEU A 1 62  ? 12.08047  -22.14912 -3.43887  1.000 17.83369  ?  143 LEU A CD1  1 
ATOM   976  C CD2  . LEU A 1 62  ? 11.86927  -22.91611 -5.73832  1.000 21.81931  ?  143 LEU A CD2  1 
ATOM   977  H H    A LEU A 1 62  ? 8.45185   -21.66843 -4.49492  0.860 14.24102  ?  143 LEU A H    1 
ATOM   978  D D    B LEU A 1 62  ? 8.45380   -21.67007 -4.49403  0.140 14.24102  ?  143 LEU A D    1 
ATOM   979  H HA   . LEU A 1 62  ? 9.28295   -23.83339 -6.06405  1.000 15.24794  ?  143 LEU A HA   1 
ATOM   980  H HB2  . LEU A 1 62  ? 9.69610   -23.21559 -3.12905  1.000 14.64096  ?  143 LEU A HB2  1 
ATOM   981  H HB3  . LEU A 1 62  ? 10.58423  -24.45968 -4.05228  1.000 14.64096  ?  143 LEU A HB3  1 
ATOM   982  H HG   . LEU A 1 62  ? 10.57865  -21.52681 -4.75236  1.000 16.58478  ?  143 LEU A HG   1 
ATOM   983  H HD11 . LEU A 1 62  ? 11.54966  -21.67533 -2.61312  1.000 21.40042  ?  143 LEU A HD11 1 
ATOM   984  H HD12 . LEU A 1 62  ? 12.53559  -23.08067 -3.10245  1.000 21.40042  ?  143 LEU A HD12 1 
ATOM   985  H HD13 . LEU A 1 62  ? 12.84864  -21.47702 -3.82135  1.000 21.40042  ?  143 LEU A HD13 1 
ATOM   986  H HD21 . LEU A 1 62  ? 12.19339  -22.04773 -6.31187  1.000 26.18317  ?  143 LEU A HD21 1 
ATOM   987  H HD22 . LEU A 1 62  ? 12.73590  -23.49366 -5.41662  1.000 26.18317  ?  143 LEU A HD22 1 
ATOM   988  H HD23 . LEU A 1 62  ? 11.21234  -23.53867 -6.34574  1.000 26.18317  ?  143 LEU A HD23 1 
ATOM   989  N N    . ALA A 1 63  ? 7.18407   -24.59852 -3.60675  1.000 14.19737  ?  144 ALA A N    1 
ATOM   990  C CA   . ALA A 1 63  ? 6.34971   -25.69497 -3.12687  1.000 14.04461  ?  144 ALA A CA   1 
ATOM   991  C C    . ALA A 1 63  ? 5.31547   -26.08929 -4.17564  1.000 12.71310  ?  144 ALA A C    1 
ATOM   992  O O    . ALA A 1 63  ? 5.02756   -27.27980 -4.33959  1.000 14.92421  ?  144 ALA A O    1 
ATOM   993  C CB   . ALA A 1 63  ? 5.64927   -25.27153 -1.82843  1.000 17.16434  ?  144 ALA A CB   1 
ATOM   994  H H    A ALA A 1 63  ? 7.07405   -23.71662 -3.10620  0.980 17.03684  ?  144 ALA A H    1 
ATOM   995  D D    B ALA A 1 63  ? 7.07227   -23.71772 -3.10465  0.020 17.03684  ?  144 ALA A D    1 
ATOM   996  H HA   . ALA A 1 63  ? 6.97703   -26.56179 -2.91906  1.000 16.85354  ?  144 ALA A HA   1 
ATOM   997  H HB1  . ALA A 1 63  ? 5.15661   -26.14011 -1.39145  1.000 20.59721  ?  144 ALA A HB1  1 
ATOM   998  H HB2  . ALA A 1 63  ? 6.39342   -24.87861 -1.13565  1.000 20.59721  ?  144 ALA A HB2  1 
ATOM   999  H HB3  . ALA A 1 63  ? 4.91194   -24.50216 -2.05760  1.000 20.59721  ?  144 ALA A HB3  1 
ATOM   1000 N N    . SER A 1 64  ? 4.73217   -25.12084 -4.86634  1.000 14.05130  ?  145 SER A N    1 
ATOM   1001 C CA   . SER A 1 64  ? 3.78404   -25.43518 -5.93440  1.000 14.12932  ?  145 SER A CA   1 
ATOM   1002 C C    . SER A 1 64  ? 4.46828   -26.18294 -7.07746  1.000 16.46733  ?  145 SER A C    1 
ATOM   1003 O O    . SER A 1 64  ? 3.90934   -27.14451 -7.62876  1.000 17.34076  ?  145 SER A O    1 
ATOM   1004 C CB   . SER A 1 64  ? 3.14162   -24.15328 -6.44771  1.000 16.82597  ?  145 SER A CB   1 
ATOM   1005 O OG   . SER A 1 64  ? 2.36432   -23.51932 -5.45412  1.000 17.46485  ?  145 SER A OG   1 
ATOM   1006 H H    A SER A 1 64  ? 4.88775   -24.12368 -4.71846  0.080 16.86156  ?  145 SER A H    1 
ATOM   1007 D D    B SER A 1 64  ? 4.88602   -24.12312 -4.72044  0.920 16.86156  ?  145 SER A D    1 
ATOM   1008 H HA   . SER A 1 64  ? 2.99844   -26.07555 -5.53332  1.000 16.95519  ?  145 SER A HA   1 
ATOM   1009 H HB2  . SER A 1 64  ? 3.92916   -23.46981 -6.76511  1.000 20.19116  ?  145 SER A HB2  1 
ATOM   1010 H HB3  . SER A 1 64  ? 2.49782   -24.39829 -7.29246  1.000 20.19116  ?  145 SER A HB3  1 
ATOM   1011 H HG   A SER A 1 64  ? 1.55573   -24.04357 -5.27592  0.140 20.95781  ?  145 SER A HG   1 
ATOM   1012 D DG   B SER A 1 64  ? 1.55977   -24.04776 -5.27008  0.860 20.95781  ?  145 SER A DG   1 
ATOM   1013 N N    . ALA A 1 65  ? 5.67763   -25.75837 -7.44699  1.000 14.02299  ?  146 ALA A N    1 
ATOM   1014 C CA   . ALA A 1 65  ? 6.40876   -26.43286 -8.49857  1.000 14.63006  ?  146 ALA A CA   1 
ATOM   1015 C C    . ALA A 1 65  ? 6.74482   -27.85460 -8.09868  1.000 14.71064  ?  146 ALA A C    1 
ATOM   1016 O O    . ALA A 1 65  ? 6.61180   -28.78453 -8.92044  1.000 15.75812  ?  146 ALA A O    1 
ATOM   1017 C CB   . ALA A 1 65  ? 7.66657   -25.63183 -8.83701  1.000 14.66919  ?  146 ALA A CB   1 
ATOM   1018 H H    A ALA A 1 65  ? 6.16502   -24.96077 -7.03872  1.000 16.82759  ?  146 ALA A H    1 
ATOM   1019 D D    B ALA A 1 65  ? 6.16710   -24.96120 -7.04038  0.000 16.82759  ?  146 ALA A D    1 
ATOM   1020 H HA   . ALA A 1 65  ? 5.79657   -26.48526 -9.39889  1.000 17.55607  ?  146 ALA A HA   1 
ATOM   1021 H HB1  . ALA A 1 65  ? 7.41701   -24.57097 -8.85698  1.000 17.60303  ?  146 ALA A HB1  1 
ATOM   1022 H HB2  . ALA A 1 65  ? 8.42347   -25.82136 -8.07591  1.000 17.60303  ?  146 ALA A HB2  1 
ATOM   1023 H HB3  . ALA A 1 65  ? 8.03492   -25.94548 -9.81376  1.000 17.60303  ?  146 ALA A HB3  1 
ATOM   1024 N N    . SER A 1 66  ? 7.12799   -28.06441 -6.83848  1.000 14.47430  ?  147 SER A N    1 
ATOM   1025 C CA   . SER A 1 66  ? 7.45149   -29.41720 -6.40317  1.000 15.30681  ?  147 SER A CA   1 
ATOM   1026 C C    . SER A 1 66  ? 6.23371   -30.32986 -6.52443  1.000 17.43430  ?  147 SER A C    1 
ATOM   1027 O O    . SER A 1 66  ? 6.33058   -31.45164 -7.04083  1.000 17.81182  ?  147 SER A O    1 
ATOM   1028 C CB   . SER A 1 66  ? 7.93950   -29.35027 -4.96654  1.000 17.50668  ?  147 SER A CB   1 
ATOM   1029 O OG   . SER A 1 66  ? 8.16205   -30.63675 -4.43954  1.000 20.23616  ?  147 SER A OG   1 
ATOM   1030 H H    A SER A 1 66  ? 7.22039   -27.34401 -6.12232  0.860 17.36915  ?  147 SER A H    1 
ATOM   1031 D D    B SER A 1 66  ? 7.22115   -27.34584 -6.12058  0.140 17.36915  ?  147 SER A D    1 
ATOM   1032 H HA   . SER A 1 66  ? 8.24102   -29.83958 -7.02473  1.000 18.36817  ?  147 SER A HA   1 
ATOM   1033 H HB2  . SER A 1 66  ? 8.87466   -28.79103 -4.93773  1.000 21.00802  ?  147 SER A HB2  1 
ATOM   1034 H HB3  . SER A 1 66  ? 7.18543   -28.84712 -4.36130  1.000 21.00802  ?  147 SER A HB3  1 
ATOM   1035 H HG   A SER A 1 66  ? 9.11742   -30.85238 -4.47389  0.180 24.28339  ?  147 SER A HG   1 
ATOM   1036 D DG   B SER A 1 66  ? 9.11145   -30.86883 -4.51153  0.820 24.28339  ?  147 SER A DG   1 
ATOM   1037 N N    . ALA A 1 67  ? 5.07522   -29.84981 -6.08514  1.000 17.00693  ?  148 ALA A N    1 
ATOM   1038 C CA   . ALA A 1 67  ? 3.86686   -30.66024 -6.15835  1.000 18.18459  ?  148 ALA A CA   1 
ATOM   1039 C C    . ALA A 1 67  ? 3.43460   -30.89346 -7.60628  1.000 19.94800  ?  148 ALA A C    1 
ATOM   1040 O O    . ALA A 1 67  ? 2.96638   -31.99183 -7.94917  1.000 19.70430  ?  148 ALA A O    1 
ATOM   1041 C CB   . ALA A 1 67  ? 2.76185   -29.97357 -5.35166  1.000 18.01930  ?  148 ALA A CB   1 
ATOM   1042 H H    A ALA A 1 67  ? 4.94198   -28.92272 -5.68122  0.840 20.40831  ?  148 ALA A H    1 
ATOM   1043 D D    B ALA A 1 67  ? 4.93939   -28.92324 -5.68089  0.160 20.40831  ?  148 ALA A D    1 
ATOM   1044 H HA   . ALA A 1 67  ? 4.05521   -31.64098 -5.72159  1.000 21.82151  ?  148 ALA A HA   1 
ATOM   1045 H HB1  . ALA A 1 67  ? 1.79321   -30.33230 -5.69975  1.000 21.62316  ?  148 ALA A HB1  1 
ATOM   1046 H HB2  . ALA A 1 67  ? 2.89041   -30.21510 -4.29656  1.000 21.62316  ?  148 ALA A HB2  1 
ATOM   1047 H HB3  . ALA A 1 67  ? 2.83343   -28.89577 -5.49765  1.000 21.62316  ?  148 ALA A HB3  1 
ATOM   1048 N N    . LEU A 1 68  ? 3.50823   -29.87290 -8.46524  1.000 17.01750  ?  149 LEU A N    1 
ATOM   1049 C CA   . LEU A 1 68  ? 3.18334   -30.06344 -9.86689  1.000 17.40710  ?  149 LEU A CA   1 
ATOM   1050 C C    . LEU A 1 68  ? 4.08256   -31.11948 -10.49163 1.000 17.84355  ?  149 LEU A C    1 
ATOM   1051 O O    . LEU A 1 68  ? 3.60527   -31.95926 -11.27370 1.000 21.12614  ?  149 LEU A O    1 
ATOM   1052 C CB   . LEU A 1 68  ? 3.33303   -28.74152 -10.61542 1.000 18.49718  ?  149 LEU A CB   1 
ATOM   1053 C CG   . LEU A 1 68  ? 2.95216   -28.73423 -12.10074 1.000 21.45786  ?  149 LEU A CG   1 
ATOM   1054 C CD1  . LEU A 1 68  ? 1.55402   -29.29273 -12.25526 1.000 29.05180  ?  149 LEU A CD1  1 
ATOM   1055 C CD2  . LEU A 1 68  ? 3.02763   -27.35301 -12.72293 1.000 23.76413  ?  149 LEU A CD2  1 
ATOM   1056 H H    A LEU A 1 68  ? 3.78505   -28.92234 -8.21985  1.000 20.42100  ?  149 LEU A H    1 
ATOM   1057 D D    B LEU A 1 68  ? 3.78472   -28.92159 -8.22241  0.000 20.42100  ?  149 LEU A D    1 
ATOM   1058 H HA   . LEU A 1 68  ? 2.14809   -30.39400 -9.95104  1.000 20.88851  ?  149 LEU A HA   1 
ATOM   1059 H HB2  . LEU A 1 68  ? 2.70089   -28.00339 -10.12179 1.000 22.19661  ?  149 LEU A HB2  1 
ATOM   1060 H HB3  . LEU A 1 68  ? 4.37814   -28.43806 -10.55402 1.000 22.19661  ?  149 LEU A HB3  1 
ATOM   1061 H HG   . LEU A 1 68  ? 3.67058   -29.35313 -12.63826 1.000 25.74944  ?  149 LEU A HG   1 
ATOM   1062 H HD11 . LEU A 1 68  ? 1.27980   -29.27610 -13.31007 1.000 34.86217  ?  149 LEU A HD11 1 
ATOM   1063 H HD12 . LEU A 1 68  ? 1.53795   -30.31712 -11.88313 1.000 34.86217  ?  149 LEU A HD12 1 
ATOM   1064 H HD13 . LEU A 1 68  ? 0.86081   -28.67784 -11.68126 1.000 34.86217  ?  149 LEU A HD13 1 
ATOM   1065 H HD21 . LEU A 1 68  ? 2.69622   -26.61579 -11.99166 1.000 28.51696  ?  149 LEU A HD21 1 
ATOM   1066 H HD22 . LEU A 1 68  ? 4.05844   -27.15066 -13.01379 1.000 28.51696  ?  149 LEU A HD22 1 
ATOM   1067 H HD23 . LEU A 1 68  ? 2.38122   -27.32311 -13.60007 1.000 28.51696  ?  149 LEU A HD23 1 
ATOM   1068 N N    . GLY A 1 69  ? 5.37973   -31.11637 -10.15721 1.000 16.41395  ?  150 GLY A N    1 
ATOM   1069 C CA   . GLY A 1 69  ? 6.27360   -32.12192 -10.68479 1.000 18.69607  ?  150 GLY A CA   1 
ATOM   1070 C C    . GLY A 1 69  ? 5.81604   -33.51529 -10.31593 1.000 23.91976  ?  150 GLY A C    1 
ATOM   1071 O O    . GLY A 1 69  ? 5.74776   -34.39871 -11.17639 1.000 23.20525  ?  150 GLY A O    1 
ATOM   1072 H H    A GLY A 1 69  ? 5.82179   -30.43971 -9.53504  0.000 19.69674  ?  150 GLY A H    1 
ATOM   1073 D D    B GLY A 1 69  ? 5.82473   -30.44126 -9.53545  1.000 19.69674  ?  150 GLY A D    1 
ATOM   1074 H HA2  . GLY A 1 69  ? 6.31044   -32.04375 -11.77136 1.000 22.43528  ?  150 GLY A HA2  1 
ATOM   1075 H HA3  . GLY A 1 69  ? 7.27515   -31.96672 -10.28367 1.000 22.43528  ?  150 GLY A HA3  1 
ATOM   1076 N N    . LYS A 1 70  ? 5.49172   -33.72700 -9.03575  1.000 22.92420  ?  151 LYS A N    1 
ATOM   1077 C CA   . LYS A 1 70  ? 4.99632   -35.04037 -8.58942  1.000 25.51107  ?  151 LYS A CA   1 
ATOM   1078 C C    . LYS A 1 70  ? 3.66133   -35.38102 -9.23783  1.000 24.14918  ?  151 LYS A C    1 
ATOM   1079 O O    . LYS A 1 70  ? 3.44900   -36.51594 -9.67820  1.000 36.57241  ?  151 LYS A O    1 
ATOM   1080 C CB   . LYS A 1 70  ? 4.90184   -35.09541 -7.06520  1.000 29.96967  ?  151 LYS A CB   1 
ATOM   1081 C CG   . LYS A 1 70  ? 6.23479   -35.15130 -6.36047  1.000 28.43310  ?  151 LYS A CG   1 
ATOM   1082 C CD   . LYS A 1 70  ? 6.11908   -35.02821 -4.84626  1.000 44.06234  ?  151 LYS A CD   1 
ATOM   1083 C CE   . LYS A 1 70  ? 7.48209   -35.20934 -4.15129  1.000 64.78538  ?  151 LYS A CE   1 
ATOM   1084 N NZ   . LYS A 1 70  ? 8.05699   -33.93297 -3.61201  1.000 69.55256  ?  151 LYS A NZ   1 
ATOM   1085 H H    A LYS A 1 70  ? 5.55746   -33.02827 -8.29557  0.330 27.50905  ?  151 LYS A H    1 
ATOM   1086 D D    B LYS A 1 70  ? 5.55654   -33.03008 -8.29378  0.670 27.50905  ?  151 LYS A D    1 
ATOM   1087 H HA   . LYS A 1 70  ? 5.71559   -35.80084 -8.89346  1.000 30.61328  ?  151 LYS A HA   1 
ATOM   1088 H HB2  . LYS A 1 70  ? 4.38159   -34.20325 -6.71664  1.000 35.96360  ?  151 LYS A HB2  1 
ATOM   1089 H HB3  . LYS A 1 70  ? 4.34214   -35.98731 -6.78351  1.000 35.96360  ?  151 LYS A HB3  1 
ATOM   1090 H HG2  . LYS A 1 70  ? 6.71273   -36.10535 -6.58287  1.000 34.11972  ?  151 LYS A HG2  1 
ATOM   1091 H HG3  . LYS A 1 70  ? 6.85758   -34.33048 -6.71609  1.000 34.11972  ?  151 LYS A HG3  1 
ATOM   1092 H HD2  . LYS A 1 70  ? 5.73634   -34.03929 -4.59397  1.000 52.87481  ?  151 LYS A HD2  1 
ATOM   1093 H HD3  . LYS A 1 70  ? 5.44149   -35.79641 -4.47366  1.000 52.87481  ?  151 LYS A HD3  1 
ATOM   1094 H HE2  . LYS A 1 70  ? 7.36185   -35.89899 -3.31582  1.000 77.74246  ?  151 LYS A HE2  1 
ATOM   1095 H HE3  . LYS A 1 70  ? 8.19246   -35.61599 -4.87110  1.000 77.74246  ?  151 LYS A HE3  1 
ATOM   1096 N N    . SER A 1 71  ? 2.78128   -34.40885 -9.39573  1.000 26.39054  ?  152 SER A N    1 
ATOM   1097 C CA   . SER A 1 71  ? 1.47817   -34.70002 -9.97861  1.000 32.98687  ?  152 SER A CA   1 
ATOM   1098 C C    . SER A 1 71  ? 1.58798   -35.13080 -11.43856 1.000 41.31323  ?  152 SER A C    1 
ATOM   1099 O O    . SER A 1 71  ? 0.70594   -35.84357 -11.93664 1.000 36.79678  ?  152 SER A O    1 
ATOM   1100 C CB   . SER A 1 71  ? 0.55569   -33.47655 -9.85988  1.000 28.72630  ?  152 SER A CB   1 
ATOM   1101 O OG   . SER A 1 71  ? 0.28613   -33.17800 -8.50109  1.000 36.39806  ?  152 SER A OG   1 
ATOM   1102 H H    A SER A 1 71  ? 2.93056   -33.43308 -9.13887  0.120 31.66864  ?  152 SER A H    1 
ATOM   1103 D D    B SER A 1 71  ? 2.92818   -33.43250 -9.13971  0.880 31.66864  ?  152 SER A D    1 
ATOM   1104 H HA   . SER A 1 71  ? 1.02996   -35.52029 -9.41793  1.000 39.58424  ?  152 SER A HA   1 
ATOM   1105 H HB2  . SER A 1 71  ? 1.04362   -32.61819 -10.32167 1.000 34.47156  ?  152 SER A HB2  1 
ATOM   1106 H HB3  . SER A 1 71  ? -0.38396  -33.68994 -10.36941 1.000 34.47156  ?  152 SER A HB3  1 
ATOM   1107 N N    . THR A 1 72  ? 2.63085   -34.68542 -12.15197 1.000 32.27361  ?  153 THR A N    1 
ATOM   1108 C CA   . THR A 1 72  ? 2.70183   -34.86564 -13.59661 1.000 25.26940  ?  153 THR A CA   1 
ATOM   1109 C C    . THR A 1 72  ? 3.84645   -35.75748 -14.02690 1.000 21.61666  ?  153 THR A C    1 
ATOM   1110 O O    . THR A 1 72  ? 3.96684   -36.03567 -15.22793 1.000 34.19905  ?  153 THR A O    1 
ATOM   1111 C CB   . THR A 1 72  ? 2.81046   -33.50970 -14.29876 1.000 36.59142  ?  153 THR A CB   1 
ATOM   1112 O OG1  . THR A 1 72  ? 3.96752   -32.83127 -13.82011 1.000 25.44981  ?  153 THR A OG1  1 
ATOM   1113 C CG2  . THR A 1 72  ? 1.58770   -32.66822 -14.04510 1.000 30.15408  ?  153 THR A CG2  1 
ATOM   1114 H H    A THR A 1 72  ? 3.43396   -34.19941 -11.75295 0.160 38.72833  ?  153 THR A H    1 
ATOM   1115 D D    B THR A 1 72  ? 3.43352   -34.19950 -11.75196 0.840 38.72833  ?  153 THR A D    1 
ATOM   1116 H HA   . THR A 1 72  ? 1.77674   -35.33335 -13.93359 1.000 30.32328  ?  153 THR A HA   1 
ATOM   1117 H HB   . THR A 1 72  ? 2.88870   -33.66029 -15.37547 1.000 43.90970  ?  153 THR A HB   1 
ATOM   1118 H HG21 . THR A 1 72  ? 1.78173   -31.63373 -14.32843 1.000 36.18490  ?  153 THR A HG21 1 
ATOM   1119 H HG22 . THR A 1 72  ? 0.74857   -33.04392 -14.63061 1.000 36.18490  ?  153 THR A HG22 1 
ATOM   1120 H HG23 . THR A 1 72  ? 1.32464   -32.70204 -12.98786 1.000 36.18490  ?  153 THR A HG23 1 
ATOM   1121 N N    . GLY A 1 73  ? 4.66278   -36.23650 -13.10025 1.000 28.11618  ?  154 GLY A N    1 
ATOM   1122 C CA   . GLY A 1 73  ? 5.83195   -37.01568 -13.46024 1.000 29.09436  ?  154 GLY A CA   1 
ATOM   1123 C C    . GLY A 1 73  ? 6.91923   -36.22754 -14.16381 1.000 41.00704  ?  154 GLY A C    1 
ATOM   1124 O O    . GLY A 1 73  ? 7.69346   -36.80248 -14.92752 1.000 32.44897  ?  154 GLY A O    1 
ATOM   1125 H H    A GLY A 1 73  ? 4.54170   -36.10248 -12.09637 0.070 33.73941  ?  154 GLY A H    1 
ATOM   1126 D D    B GLY A 1 73  ? 4.54300   -36.10331 -12.09610 0.930 33.73941  ?  154 GLY A D    1 
ATOM   1127 H HA2  . GLY A 1 73  ? 6.26185   -37.44260 -12.55414 1.000 34.91323  ?  154 GLY A HA2  1 
ATOM   1128 H HA3  . GLY A 1 73  ? 5.52418   -37.82494 -14.12241 1.000 34.91323  ?  154 GLY A HA3  1 
ATOM   1129 N N    . THR A 1 74  ? 7.00456   -34.92386 -13.92566 1.000 27.82596  ?  155 THR A N    1 
ATOM   1130 C CA   . THR A 1 74  ? 8.02043   -34.07444 -14.54296 1.000 20.63976  ?  155 THR A CA   1 
ATOM   1131 C C    . THR A 1 74  ? 8.95012   -33.50197 -13.47274 1.000 23.02360  ?  155 THR A C    1 
ATOM   1132 O O    . THR A 1 74  ? 8.71489   -33.62365 -12.26869 1.000 23.79591  ?  155 THR A O    1 
ATOM   1133 C CB   . THR A 1 74  ? 7.34320   -32.92078 -15.24655 1.000 20.75414  ?  155 THR A CB   1 
ATOM   1134 O OG1  . THR A 1 74  ? 6.51019   -32.23691 -14.29750 1.000 23.50630  ?  155 THR A OG1  1 
ATOM   1135 C CG2  . THR A 1 74  ? 6.46479   -33.40963 -16.42094 1.000 28.37180  ?  155 THR A CG2  1 
ATOM   1136 H H    A THR A 1 74  ? 6.37572   -34.41909 -13.30103 0.000 33.39115  ?  155 THR A H    1 
ATOM   1137 D D    B THR A 1 74  ? 6.37452   -34.42118 -13.30056 1.000 33.39115  ?  155 THR A D    1 
ATOM   1138 H HA   . THR A 1 74  ? 8.61212   -34.66453 -15.24281 1.000 24.76771  ?  155 THR A HA   1 
ATOM   1139 H HB   . THR A 1 74  ? 8.09940   -32.25058 -15.65532 1.000 24.90497  ?  155 THR A HB   1 
ATOM   1140 H HG1  A THR A 1 74  ? 5.59346   -32.17635 -14.63861 0.150 28.20756  ?  155 THR A HG1  1 
ATOM   1141 D DG1  B THR A 1 74  ? 5.56882   -32.31931 -14.55721 0.850 28.20756  ?  155 THR A DG1  1 
ATOM   1142 H HG21 . THR A 1 74  ? 6.44518   -32.65784 -17.20994 1.000 34.04616  ?  155 THR A HG21 1 
ATOM   1143 H HG22 . THR A 1 74  ? 6.86752   -34.33773 -16.82658 1.000 34.04616  ?  155 THR A HG22 1 
ATOM   1144 H HG23 . THR A 1 74  ? 5.44616   -33.58699 -16.07593 1.000 34.04616  ?  155 THR A HG23 1 
ATOM   1145 N N    . LYS A 1 75  ? 10.03469  -32.89989 -13.93760 1.000 16.60578  ?  156 LYS A N    1 
ATOM   1146 C CA   . LYS A 1 75  ? 10.94600  -32.12885 -13.11019 1.000 18.34379  ?  156 LYS A CA   1 
ATOM   1147 C C    . LYS A 1 75  ? 10.73753  -30.65881 -13.46474 1.000 16.22398  ?  156 LYS A C    1 
ATOM   1148 O O    . LYS A 1 75  ? 10.69725  -30.29067 -14.64337 1.000 17.79273  ?  156 LYS A O    1 
ATOM   1149 C CB   . LYS A 1 75  ? 12.37960  -32.54615 -13.42476 1.000 22.66715  ?  156 LYS A CB   1 
ATOM   1150 C CG   . LYS A 1 75  ? 12.66198  -33.99955 -13.06343 1.000 29.80904  ?  156 LYS A CG   1 
ATOM   1151 C CD   . LYS A 1 75  ? 14.15035  -34.34565 -13.11875 1.000 45.92727  ?  156 LYS A CD   1 
ATOM   1152 C CE   . LYS A 1 75  ? 14.69665  -34.37661 -14.54666 1.000 73.42828  ?  156 LYS A CE   1 
ATOM   1153 N NZ   . LYS A 1 75  ? 14.42300  -35.66197 -15.26024 1.000 105.38740 ?  156 LYS A NZ   1 
ATOM   1154 H H    A LYS A 1 75  ? 10.31685  -32.93019 -14.91733 0.230 19.92694  ?  156 LYS A H    1 
ATOM   1155 D D    B LYS A 1 75  ? 10.31489  -32.93157 -14.91785 0.770 19.92694  ?  156 LYS A D    1 
ATOM   1156 H HA   . LYS A 1 75  ? 10.76039  -32.27556 -12.04618 1.000 22.01255  ?  156 LYS A HA   1 
ATOM   1157 H HB2  . LYS A 1 75  ? 12.55898  -32.42262 -14.49278 1.000 27.20059  ?  156 LYS A HB2  1 
ATOM   1158 H HB3  . LYS A 1 75  ? 13.06508  -31.91748 -12.85644 1.000 27.20059  ?  156 LYS A HB3  1 
ATOM   1159 H HG2  . LYS A 1 75  ? 12.31021  -34.18846 -12.04920 1.000 35.77085  ?  156 LYS A HG2  1 
ATOM   1160 H HG3  . LYS A 1 75  ? 12.13941  -34.64851 -13.76620 1.000 35.77085  ?  156 LYS A HG3  1 
ATOM   1161 H HD2  . LYS A 1 75  ? 14.71094  -33.59633 -12.55985 1.000 55.11272  ?  156 LYS A HD2  1 
ATOM   1162 H HD3  . LYS A 1 75  ? 14.30321  -35.33088 -12.67823 1.000 55.11272  ?  156 LYS A HD3  1 
ATOM   1163 H HE2  . LYS A 1 75  ? 14.23386  -33.57243 -15.11870 1.000 88.11394  ?  156 LYS A HE2  1 
ATOM   1164 H HE3  . LYS A 1 75  ? 15.77715  -34.23677 -14.51385 1.000 88.11394  ?  156 LYS A HE3  1 
ATOM   1165 N N    . GLN A 1 76  ? 10.54161  -29.84195 -12.45387 1.000 15.30204  ?  157 GLN A N    1 
ATOM   1166 C CA   . GLN A 1 76  ? 10.15180  -28.45396 -12.63388 1.000 13.17157  ?  157 GLN A CA   1 
ATOM   1167 C C    . GLN A 1 76  ? 11.32829  -27.51448 -12.37619 1.000 13.02893  ?  157 GLN A C    1 
ATOM   1168 O O    . GLN A 1 76  ? 12.22101  -27.79698 -11.56700 1.000 14.27610  ?  157 GLN A O    1 
ATOM   1169 C CB   . GLN A 1 76  ? 9.00127   -28.12003 -11.69251 1.000 14.28102  ?  157 GLN A CB   1 
ATOM   1170 C CG   . GLN A 1 76  ? 7.71702   -28.86989 -11.99071 1.000 16.06016  ?  157 GLN A CG   1 
ATOM   1171 C CD   . GLN A 1 76  ? 6.96547   -28.39055 -13.15821 1.000 17.35530  ?  157 GLN A CD   1 
ATOM   1172 O OE1  . GLN A 1 76  ? 6.80902   -27.19977 -13.36923 1.000 19.98880  ?  157 GLN A OE1  1 
ATOM   1173 N NE2  . GLN A 1 76  ? 6.43591   -29.33957 -13.95203 1.000 20.03767  ?  157 GLN A NE2  1 
ATOM   1174 H H    A GLN A 1 76  ? 10.64594  -30.11273 -11.47602 0.000 18.36245  ?  157 GLN A H    1 
ATOM   1175 D D    B GLN A 1 76  ? 10.64638  -30.11435 -11.47652 1.000 18.36245  ?  157 GLN A D    1 
ATOM   1176 H HA   . GLN A 1 76  ? 9.83104   -28.29214 -13.66298 1.000 15.80588  ?  157 GLN A HA   1 
ATOM   1177 H HB2  . GLN A 1 76  ? 9.30064   -28.36863 -10.67433 1.000 17.13722  ?  157 GLN A HB2  1 
ATOM   1178 H HB3  . GLN A 1 76  ? 8.78707   -27.05398 -11.76834 1.000 17.13722  ?  157 GLN A HB3  1 
ATOM   1179 H HG2  . GLN A 1 76  ? 7.96358   -29.91627 -12.17068 1.000 19.27219  ?  157 GLN A HG2  1 
ATOM   1180 H HG3  . GLN A 1 76  ? 7.06033   -28.78520 -11.12486 1.000 19.27219  ?  157 GLN A HG3  1 
ATOM   1181 H HE21 A GLN A 1 76  ? 5.90226   -29.07296 -14.77940 0.100 24.04521  ?  157 GLN A HE21 1 
ATOM   1182 D DE21 B GLN A 1 76  ? 5.90226   -29.07296 -14.77940 0.900 24.04521  ?  157 GLN A DE21 1 
ATOM   1183 H HE22 A GLN A 1 76  ? 6.56821   -30.32544 -13.72631 0.000 24.04521  ?  157 GLN A HE22 1 
ATOM   1184 D DE22 B GLN A 1 76  ? 6.56821   -30.32544 -13.72631 1.000 24.04521  ?  157 GLN A DE22 1 
ATOM   1185 N N    . LEU A 1 77  ? 11.28506  -26.38011 -13.05377 1.000 12.09768  ?  158 LEU A N    1 
ATOM   1186 C CA   . LEU A 1 77  ? 12.33447  -25.35324 -12.99242 1.000 12.34977  ?  158 LEU A CA   1 
ATOM   1187 C C    . LEU A 1 77  ? 11.69456  -23.99369 -12.76148 1.000 11.58246  ?  158 LEU A C    1 
ATOM   1188 O O    . LEU A 1 77  ? 10.72159  -23.63126 -13.44925 1.000 13.01455  ?  158 LEU A O    1 
ATOM   1189 C CB   . LEU A 1 77  ? 13.11730  -25.41356 -14.32858 1.000 13.09361  ?  158 LEU A CB   1 
ATOM   1190 C CG   . LEU A 1 77  ? 14.30774  -24.47465 -14.52267 1.000 13.59939  ?  158 LEU A CG   1 
ATOM   1191 C CD1  . LEU A 1 77  ? 15.20074  -25.06276 -15.59109 1.000 15.92538  ?  158 LEU A CD1  1 
ATOM   1192 C CD2  . LEU A 1 77  ? 13.94828  -23.05882 -14.90011 1.000 14.87605  ?  158 LEU A CD2  1 
ATOM   1193 H H    A LEU A 1 77  ? 10.51723  -26.12621 -13.67536 0.970 14.51721  ?  158 LEU A H    1 
ATOM   1194 D D    B LEU A 1 77  ? 10.51632  -26.12792 -13.67494 0.030 14.51721  ?  158 LEU A D    1 
ATOM   1195 H HA   . LEU A 1 77  ? 13.01926  -25.50097 -12.15735 1.000 14.81972  ?  158 LEU A HA   1 
ATOM   1196 H HB2  . LEU A 1 77  ? 13.50132  -26.42774 -14.43845 1.000 15.71233  ?  158 LEU A HB2  1 
ATOM   1197 H HB3  . LEU A 1 77  ? 12.41392  -25.19225 -15.13131 1.000 15.71233  ?  158 LEU A HB3  1 
ATOM   1198 H HG   . LEU A 1 77  ? 14.81218  -24.39199 -13.55996 1.000 16.31927  ?  158 LEU A HG   1 
ATOM   1199 H HD11 . LEU A 1 77  ? 14.66463  -25.06477 -16.54013 1.000 19.11045  ?  158 LEU A HD11 1 
ATOM   1200 H HD12 . LEU A 1 77  ? 16.10182  -24.45513 -15.67448 1.000 19.11045  ?  158 LEU A HD12 1 
ATOM   1201 H HD13 . LEU A 1 77  ? 15.46472  -26.08259 -15.31115 1.000 19.11045  ?  158 LEU A HD13 1 
ATOM   1202 H HD21 . LEU A 1 77  ? 14.41108  -22.81832 -15.85723 1.000 17.85125  ?  158 LEU A HD21 1 
ATOM   1203 H HD22 . LEU A 1 77  ? 12.86430  -22.97729 -14.98046 1.000 17.85125  ?  158 LEU A HD22 1 
ATOM   1204 H HD23 . LEU A 1 77  ? 14.31580  -22.38178 -14.12898 1.000 17.85125  ?  158 LEU A HD23 1 
ATOM   1205 N N    . VAL A 1 78  ? 12.20209  -23.26256 -11.76835 1.000 11.00142  ?  159 VAL A N    1 
ATOM   1206 C CA   . VAL A 1 78  ? 11.71708  -21.93493 -11.41295 1.000 10.44176  ?  159 VAL A CA   1 
ATOM   1207 C C    . VAL A 1 78  ? 12.77816  -20.90388 -11.80517 1.000 11.37459  ?  159 VAL A C    1 
ATOM   1208 O O    . VAL A 1 78  ? 13.96781  -21.05861 -11.48923 1.000 12.19257  ?  159 VAL A O    1 
ATOM   1209 C CB   . VAL A 1 78  ? 11.39974  -21.90328 -9.90065  1.000 12.44321  ?  159 VAL A CB   1 
ATOM   1210 C CG1  . VAL A 1 78  ? 11.09391  -20.52662 -9.42874  1.000 15.23107  ?  159 VAL A CG1  1 
ATOM   1211 C CG2  . VAL A 1 78  ? 10.21725  -22.84206 -9.56093  1.000 13.83647  ?  159 VAL A CG2  1 
ATOM   1212 H H    A VAL A 1 78  ? 12.97214  -23.57612 -11.17750 0.990 13.20170  ?  159 VAL A H    1 
ATOM   1213 D D    B VAL A 1 78  ? 12.97225  -23.57838 -11.17885 0.010 13.20170  ?  159 VAL A D    1 
ATOM   1214 H HA   . VAL A 1 78  ? 10.81556  -21.68013 -11.97012 1.000 12.53011  ?  159 VAL A HA   1 
ATOM   1215 H HB   . VAL A 1 78  ? 12.29024  -22.25166 -9.37745  1.000 14.93185  ?  159 VAL A HB   1 
ATOM   1216 H HG11 . VAL A 1 78  ? 11.60621  -19.80958 -10.07023 1.000 18.27728  ?  159 VAL A HG11 1 
ATOM   1217 H HG12 . VAL A 1 78  ? 10.01694  -20.36583 -9.47751  1.000 18.27728  ?  159 VAL A HG12 1 
ATOM   1218 H HG13 . VAL A 1 78  ? 11.43963  -20.41891 -8.40065  1.000 18.27728  ?  159 VAL A HG13 1 
ATOM   1219 H HG21 . VAL A 1 78  ? 10.28558  -23.73696 -10.17947 1.000 16.60377  ?  159 VAL A HG21 1 
ATOM   1220 H HG22 . VAL A 1 78  ? 10.27143  -23.11382 -8.50674  1.000 16.60377  ?  159 VAL A HG22 1 
ATOM   1221 H HG23 . VAL A 1 78  ? 9.28129   -22.32121 -9.76289  1.000 16.60377  ?  159 VAL A HG23 1 
ATOM   1222 N N    . GLN A 1 79  ? 12.33309  -19.83133 -12.42854 1.000 10.89400  ?  160 GLN A N    1 
ATOM   1223 C CA   . GLN A 1 79  ? 13.20284  -18.78004 -12.97104 1.000 10.04832  ?  160 GLN A CA   1 
ATOM   1224 C C    . GLN A 1 79  ? 13.04843  -17.51666 -12.14839 1.000 10.65881  ?  160 GLN A C    1 
ATOM   1225 O O    . GLN A 1 79  ? 11.93183  -16.97630 -12.05190 1.000 11.62491  ?  160 GLN A O    1 
ATOM   1226 C CB   . GLN A 1 79  ? 12.76905  -18.49107 -14.41136 1.000 12.04521  ?  160 GLN A CB   1 
ATOM   1227 C CG   . GLN A 1 79  ? 12.85478  -19.71401 -15.31014 1.000 12.50856  ?  160 GLN A CG   1 
ATOM   1228 C CD   . GLN A 1 79  ? 12.55875  -19.42193 -16.76835 1.000 12.98702  ?  160 GLN A CD   1 
ATOM   1229 O OE1  . GLN A 1 79  ? 13.19849  -19.97864 -17.63925 1.000 14.56959  ?  160 GLN A OE1  1 
ATOM   1230 N NE2  . GLN A 1 79  ? 11.58788  -18.55953 -17.03873 1.000 12.49236  ?  160 GLN A NE2  1 
ATOM   1231 H H    A GLN A 1 79  ? 11.34249  -19.64500 -12.58473 0.870 13.07280  ?  160 GLN A H    1 
ATOM   1232 D D    B GLN A 1 79  ? 11.34189  -19.64718 -12.58355 0.130 13.07280  ?  160 GLN A D    1 
ATOM   1233 H HA   . GLN A 1 79  ? 14.24571  -19.09347 -12.92335 1.000 12.05798  ?  160 GLN A HA   1 
ATOM   1234 H HB2  . GLN A 1 79  ? 11.73471  -18.14723 -14.40768 1.000 14.45425  ?  160 GLN A HB2  1 
ATOM   1235 H HB3  . GLN A 1 79  ? 13.41674  -17.72000 -14.82855 1.000 14.45425  ?  160 GLN A HB3  1 
ATOM   1236 H HG2  . GLN A 1 79  ? 13.86349  -20.12281 -15.25123 1.000 15.01027  ?  160 GLN A HG2  1 
ATOM   1237 H HG3  . GLN A 1 79  ? 12.13202  -20.45380 -14.96602 1.000 15.01027  ?  160 GLN A HG3  1 
ATOM   1238 H HE21 A GLN A 1 79  ? 11.07047  -18.11909 -16.27801 0.090 14.99084  ?  160 GLN A HE21 1 
ATOM   1239 D DE21 B GLN A 1 79  ? 11.07047  -18.11909 -16.27801 0.910 14.99084  ?  160 GLN A DE21 1 
ATOM   1240 H HE22 A GLN A 1 79  ? 11.35870  -18.33681 -18.00738 0.160 14.99084  ?  160 GLN A HE22 1 
ATOM   1241 D DE22 B GLN A 1 79  ? 11.35870  -18.33681 -18.00738 0.840 14.99084  ?  160 GLN A DE22 1 
ATOM   1242 N N    . ILE A 1 80  ? 14.13829  -17.03562 -11.54273 1.000 9.67414   ?  161 ILE A N    1 
ATOM   1243 C CA   . ILE A 1 80  ? 14.08968  -15.86789 -10.66723 1.000 9.99017   ?  161 ILE A CA   1 
ATOM   1244 C C    . ILE A 1 80  ? 15.15842  -14.85596 -11.01783 1.000 10.05593  ?  161 ILE A C    1 
ATOM   1245 O O    . ILE A 1 80  ? 16.17354  -15.17714 -11.64249 1.000 10.35619  ?  161 ILE A O    1 
ATOM   1246 C CB   . ILE A 1 80  ? 14.21843  -16.22403 -9.16872  1.000 11.26130  ?  161 ILE A CB   1 
ATOM   1247 C CG1  . ILE A 1 80  ? 15.55334  -16.89238 -8.88248  1.000 13.49145  ?  161 ILE A CG1  1 
ATOM   1248 C CG2  . ILE A 1 80  ? 13.06376  -17.16166 -8.77161  1.000 15.59252  ?  161 ILE A CG2  1 
ATOM   1249 C CD1  . ILE A 1 80  ? 15.79953  -17.22604 -7.38725  1.000 16.39009  ?  161 ILE A CD1  1 
ATOM   1250 H H    A ILE A 1 80  ? 15.07049  -17.43756 -11.64199 1.000 11.60896  ?  161 ILE A H    1 
ATOM   1251 D D    B ILE A 1 80  ? 15.06983  -17.43882 -11.64309 0.000 11.60896  ?  161 ILE A D    1 
ATOM   1252 H HA   . ILE A 1 80  ? 13.12253  -15.40089 -10.85335 1.000 11.98821  ?  161 ILE A HA   1 
ATOM   1253 H HB   . ILE A 1 80  ? 14.16889  -15.30490 -8.58489  1.000 13.51356  ?  161 ILE A HB   1 
ATOM   1254 H HG12 . ILE A 1 80  ? 15.59980  -17.82774 -9.44018  1.000 16.18974  ?  161 ILE A HG12 1 
ATOM   1255 H HG13 . ILE A 1 80  ? 16.35206  -16.22513 -9.20641  1.000 16.18974  ?  161 ILE A HG13 1 
ATOM   1256 H HG21 . ILE A 1 80  ? 13.06525  -17.28763 -7.68892  1.000 18.71102  ?  161 ILE A HG21 1 
ATOM   1257 H HG22 . ILE A 1 80  ? 12.12084  -16.71928 -9.09305  1.000 18.71102  ?  161 ILE A HG22 1 
ATOM   1258 H HG23 . ILE A 1 80  ? 13.20669  -18.12646 -9.25827  1.000 18.71102  ?  161 ILE A HG23 1 
ATOM   1259 H HD11 . ILE A 1 80  ? 15.48674  -16.37790 -6.77822  1.000 19.66811  ?  161 ILE A HD11 1 
ATOM   1260 H HD12 . ILE A 1 80  ? 15.21916  -18.10929 -7.12053  1.000 19.66811  ?  161 ILE A HD12 1 
ATOM   1261 H HD13 . ILE A 1 80  ? 16.86160  -17.41987 -7.23711  1.000 19.66811  ?  161 ILE A HD13 1 
ATOM   1262 N N    . VAL A 1 81  ? 14.92888  -13.60878 -10.63047 1.000 10.77528  ?  162 VAL A N    1 
ATOM   1263 C CA   . VAL A 1 81  ? 15.89784  -12.52749 -10.74726 1.000 9.54044   ?  162 VAL A CA   1 
ATOM   1264 C C    . VAL A 1 81  ? 16.20579  -12.03011 -9.34090  1.000 10.31497  ?  162 VAL A C    1 
ATOM   1265 O O    . VAL A 1 81  ? 15.28891  -11.73346 -8.56074  1.000 12.39684  ?  162 VAL A O    1 
ATOM   1266 C CB   . VAL A 1 81  ? 15.38972  -11.37376 -11.61716 1.000 10.46165  ?  162 VAL A CB   1 
ATOM   1267 C CG1  . VAL A 1 81  ? 16.47093  -10.32691 -11.79056 1.000 11.82747  ?  162 VAL A CG1  1 
ATOM   1268 C CG2  . VAL A 1 81  ? 14.89538  -11.86037 -12.94263 1.000 12.43294  ?  162 VAL A CG2  1 
ATOM   1269 H H    A VAL A 1 81  ? 14.04752  -13.30534 -10.21630 1.000 12.93034  ?  162 VAL A H    1 
ATOM   1270 D D    B VAL A 1 81  ? 14.04654  -13.30788 -10.21653 0.000 12.93034  ?  162 VAL A D    1 
ATOM   1271 H HA   . VAL A 1 81  ? 16.80754  -12.91627 -11.20485 1.000 11.44852  ?  162 VAL A HA   1 
ATOM   1272 H HB   . VAL A 1 81  ? 14.54289  -10.91021 -11.11110 1.000 12.55398  ?  162 VAL A HB   1 
ATOM   1273 H HG11 . VAL A 1 81  ? 17.44601  -10.80982 -11.72644 1.000 14.19297  ?  162 VAL A HG11 1 
ATOM   1274 H HG12 . VAL A 1 81  ? 16.35380  -9.85389  -12.76556 1.000 14.19297  ?  162 VAL A HG12 1 
ATOM   1275 H HG13 . VAL A 1 81  ? 16.37279  -9.58133  -11.00152 1.000 14.19297  ?  162 VAL A HG13 1 
ATOM   1276 H HG21 . VAL A 1 81  ? 14.48206  -11.01850 -13.49807 1.000 14.91953  ?  162 VAL A HG21 1 
ATOM   1277 H HG22 . VAL A 1 81  ? 15.72858  -12.29626 -13.49388 1.000 14.91953  ?  162 VAL A HG22 1 
ATOM   1278 H HG23 . VAL A 1 81  ? 14.12371  -12.61264 -12.77918 1.000 14.91953  ?  162 VAL A HG23 1 
ATOM   1279 N N    . ILE A 1 82  ? 17.47402  -11.96710 -9.00606  1.000 9.49128   ?  163 ILE A N    1 
ATOM   1280 C CA   . ILE A 1 82  ? 17.96145  -11.39256 -7.75576  1.000 10.56940  ?  163 ILE A CA   1 
ATOM   1281 C C    . ILE A 1 82  ? 18.25147  -9.92266  -8.04741  1.000 10.44454  ?  163 ILE A C    1 
ATOM   1282 O O    . ILE A 1 82  ? 19.11639  -9.60888  -8.87701  1.000 11.02278  ?  163 ILE A O    1 
ATOM   1283 C CB   . ILE A 1 82  ? 19.24389  -12.12372 -7.33626  1.000 12.47769  ?  163 ILE A CB   1 
ATOM   1284 C CG1  . ILE A 1 82  ? 19.04064  -13.65476 -7.25167  1.000 18.85070  ?  163 ILE A CG1  1 
ATOM   1285 C CG2  . ILE A 1 82  ? 19.80040  -11.60274 -6.04875  1.000 15.00217  ?  163 ILE A CG2  1 
ATOM   1286 C CD1  . ILE A 1 82  ? 18.12793  -14.05798 -6.27669  1.000 21.05034  ?  163 ILE A CD1  1 
ATOM   1287 H H    A ILE A 1 82  ? 18.22762  -12.31745 -9.59745  1.000 11.38954  ?  163 ILE A H    1 
ATOM   1288 D D    B ILE A 1 82  ? 18.22675  -12.31781 -9.59834  0.000 11.38954  ?  163 ILE A D    1 
ATOM   1289 H HA   . ILE A 1 82  ? 17.22390  -11.46660 -6.95661  1.000 12.68328  ?  163 ILE A HA   1 
ATOM   1290 H HB   . ILE A 1 82  ? 19.96934  -11.92058 -8.12401  1.000 14.97323  ?  163 ILE A HB   1 
ATOM   1291 H HG12 . ILE A 1 82  ? 18.67477  -14.01141 -8.21450  1.000 22.62084  ?  163 ILE A HG12 1 
ATOM   1292 H HG13 . ILE A 1 82  ? 19.99838  -14.12117 -7.02080  1.000 22.62084  ?  163 ILE A HG13 1 
ATOM   1293 H HG21 . ILE A 1 82  ? 19.07862  -11.78192 -5.25186  1.000 18.00261  ?  163 ILE A HG21 1 
ATOM   1294 H HG22 . ILE A 1 82  ? 20.73308  -12.12237 -5.82923  1.000 18.00261  ?  163 ILE A HG22 1 
ATOM   1295 H HG23 . ILE A 1 82  ? 19.98546  -10.53326 -6.14909  1.000 18.00261  ?  163 ILE A HG23 1 
ATOM   1296 H HD11 . ILE A 1 82  ? 18.59585  -13.97334 -5.29588  1.000 25.26041  ?  163 ILE A HD11 1 
ATOM   1297 H HD12 . ILE A 1 82  ? 17.24898  -13.41523 -6.32592  1.000 25.26041  ?  163 ILE A HD12 1 
ATOM   1298 H HD13 . ILE A 1 82  ? 17.84245  -15.09307 -6.46425  1.000 25.26041  ?  163 ILE A HD13 1 
ATOM   1299 N N    . TYR A 1 83  ? 17.50585  -9.00578  -7.40598  1.000 10.24033  ?  164 TYR A N    1 
ATOM   1300 C CA   . TYR A 1 83  ? 17.60580  -7.60403  -7.75320  1.000 10.48914  ?  164 TYR A CA   1 
ATOM   1301 C C    . TYR A 1 83  ? 17.35248  -6.72067  -6.53586  1.000 11.69829  ?  164 TYR A C    1 
ATOM   1302 O O    . TYR A 1 83  ? 16.30989  -6.05263  -6.43982  1.000 12.49179  ?  164 TYR A O    1 
ATOM   1303 C CB   . TYR A 1 83  ? 16.57401  -7.30210  -8.83398  1.000 11.79155  ?  164 TYR A CB   1 
ATOM   1304 C CG   . TYR A 1 83  ? 16.63892  -5.92053  -9.45253  1.000 11.20818  ?  164 TYR A CG   1 
ATOM   1305 C CD1  . TYR A 1 83  ? 17.83110  -5.35962  -9.84880  1.000 12.51206  ?  164 TYR A CD1  1 
ATOM   1306 C CD2  . TYR A 1 83  ? 15.48569  -5.21299  -9.70292  1.000 12.46072  ?  164 TYR A CD2  1 
ATOM   1307 C CE1  . TYR A 1 83  ? 17.87462  -4.10046  -10.46497 1.000 12.53136  ?  164 TYR A CE1  1 
ATOM   1308 C CE2  . TYR A 1 83  ? 15.51208  -3.98960  -10.28792 1.000 14.33867  ?  164 TYR A CE2  1 
ATOM   1309 C CZ   . TYR A 1 83  ? 16.69955  -3.43565  -10.68526 1.000 13.26739  ?  164 TYR A CZ   1 
ATOM   1310 O OH   . TYR A 1 83  ? 16.70080  -2.19330  -11.30491 1.000 16.38112  ?  164 TYR A OH   1 
ATOM   1311 H H    A TYR A 1 83  ? 16.84292  -9.21636  -6.65994  1.000 12.28839  ?  164 TYR A H    1 
ATOM   1312 D D    B TYR A 1 83  ? 16.84342  -9.21851  -6.66010  0.000 12.28839  ?  164 TYR A D    1 
ATOM   1313 H HA   . TYR A 1 83  ? 18.62526  -7.39413  -8.07685  1.000 12.58697  ?  164 TYR A HA   1 
ATOM   1314 H HB2  . TYR A 1 83  ? 16.70710  -8.02199  -9.64153  1.000 14.14985  ?  164 TYR A HB2  1 
ATOM   1315 H HB3  . TYR A 1 83  ? 15.58165  -7.41174  -8.39660  1.000 14.14985  ?  164 TYR A HB3  1 
ATOM   1316 H HD1  . TYR A 1 83  ? 18.75148  -5.89953  -9.68211  1.000 15.01447  ?  164 TYR A HD1  1 
ATOM   1317 H HD2  . TYR A 1 83  ? 14.53444  -5.64312  -9.42634  1.000 14.95286  ?  164 TYR A HD2  1 
ATOM   1318 H HE1  . TYR A 1 83  ? 18.81755  -3.66418  -10.75981 1.000 15.03763  ?  164 TYR A HE1  1 
ATOM   1319 H HE2  . TYR A 1 83  ? 14.59003  -3.44861  -10.44141 1.000 17.20640  ?  164 TYR A HE2  1 
ATOM   1320 H HH   A TYR A 1 83  ? 17.60984  -1.82751  -11.32065 0.000 19.65735  ?  164 TYR A HH   1 
ATOM   1321 D DH   B TYR A 1 83  ? 17.60613  -1.81810  -11.30181 1.000 19.65735  ?  164 TYR A DH   1 
ATOM   1322 N N    . ASP A 1 84  ? 18.31218  -6.68609  -5.62030  1.000 10.39459  ?  165 ASP A N    1 
ATOM   1323 C CA   . ASP A 1 84  ? 18.13285  -5.84745  -4.42109  1.000 10.42171  ?  165 ASP A CA   1 
ATOM   1324 C C    . ASP A 1 84  ? 19.44217  -5.30300  -3.87599  1.000 11.26541  ?  165 ASP A C    1 
ATOM   1325 O O    . ASP A 1 84  ? 19.55485  -5.08919  -2.66170  1.000 11.91364  ?  165 ASP A O    1 
ATOM   1326 C CB   . ASP A 1 84  ? 17.34553  -6.60269  -3.35716  1.000 11.87996  ?  165 ASP A CB   1 
ATOM   1327 C CG   . ASP A 1 84  ? 16.52695  -5.68057  -2.43659  1.000 12.91759  ?  165 ASP A CG   1 
ATOM   1328 O OD1  . ASP A 1 84  ? 16.44506  -4.51222  -2.63315  1.000 13.95647  ?  165 ASP A OD1  1 
ATOM   1329 O OD2  . ASP A 1 84  ? 15.96898  -6.33352  -1.44283  1.000 15.28964  -1 165 ASP A OD2  1 
ATOM   1330 H H    A ASP A 1 84  ? 19.19154  -7.20080  -5.66734  0.920 12.47350  ?  165 ASP A H    1 
ATOM   1331 D D    B ASP A 1 84  ? 19.19185  -7.20036  -5.66636  0.080 12.47350  ?  165 ASP A D    1 
ATOM   1332 H HA   . ASP A 1 84  ? 17.54994  -4.96758  -4.69340  1.000 12.50605  ?  165 ASP A HA   1 
ATOM   1333 H HB2  . ASP A 1 84  ? 16.65235  -7.28504  -3.84909  1.000 14.25595  ?  165 ASP A HB2  1 
ATOM   1334 H HB3  . ASP A 1 84  ? 18.04230  -7.16387  -2.73451  1.000 14.25595  ?  165 ASP A HB3  1 
ATOM   1335 D DD2  . ASP A 1 84  ? 15.43334  -5.66963  -0.88361  0.770 18.34757  ?  165 ASP A DD2  1 
ATOM   1336 N N    . LEU A 1 85  ? 20.42058  -5.00795  -4.72305  1.000 11.47432  ?  166 LEU A N    1 
ATOM   1337 C CA   . LEU A 1 85  ? 21.66964  -4.48366  -4.21232  1.000 10.92476  ?  166 LEU A CA   1 
ATOM   1338 C C    . LEU A 1 85  ? 21.44376  -3.18488  -3.44091  1.000 13.13322  ?  166 LEU A C    1 
ATOM   1339 O O    . LEU A 1 85  ? 20.59064  -2.36817  -3.81843  1.000 13.71941  ?  166 LEU A O    1 
ATOM   1340 C CB   . LEU A 1 85  ? 22.66558  -4.18388  -5.32108  1.000 11.86891  ?  166 LEU A CB   1 
ATOM   1341 C CG   . LEU A 1 85  ? 23.43695  -5.36534  -5.86414  1.000 11.92136  ?  166 LEU A CG   1 
ATOM   1342 C CD1  . LEU A 1 85  ? 24.23518  -5.01450  -7.06730  1.000 14.93507  ?  166 LEU A CD1  1 
ATOM   1343 C CD2  . LEU A 1 85  ? 24.34196  -5.98327  -4.85266  1.000 15.62408  ?  166 LEU A CD2  1 
ATOM   1344 H H    A LEU A 1 85  ? 20.37685  -5.11858  -5.73609  1.000 13.76919  ?  166 LEU A H    1 
ATOM   1345 D D    B LEU A 1 85  ? 20.37874  -5.11788  -5.73624  0.000 13.76919  ?  166 LEU A D    1 
ATOM   1346 H HA   . LEU A 1 85  ? 22.08588  -5.24651  -3.55438  1.000 13.10972  ?  166 LEU A HA   1 
ATOM   1347 H HB2  . LEU A 1 85  ? 22.12043  -3.74437  -6.15639  1.000 14.24269  ?  166 LEU A HB2  1 
ATOM   1348 H HB3  . LEU A 1 85  ? 23.39615  -3.47203  -4.93685  1.000 14.24269  ?  166 LEU A HB3  1 
ATOM   1349 H HG   . LEU A 1 85  ? 22.68127  -6.09998  -6.14226  1.000 14.30563  ?  166 LEU A HG   1 
ATOM   1350 H HD11 . LEU A 1 85  ? 24.72265  -4.05370  -6.90199  1.000 17.92208  ?  166 LEU A HD11 1 
ATOM   1351 H HD12 . LEU A 1 85  ? 24.98497  -5.78797  -7.23366  1.000 17.92208  ?  166 LEU A HD12 1 
ATOM   1352 H HD13 . LEU A 1 85  ? 23.56984  -4.95047  -7.92831  1.000 17.92208  ?  166 LEU A HD13 1 
ATOM   1353 H HD21 . LEU A 1 85  ? 24.84715  -6.83754  -5.30335  1.000 18.74889  ?  166 LEU A HD21 1 
ATOM   1354 H HD22 . LEU A 1 85  ? 25.07591  -5.24311  -4.53397  1.000 18.74889  ?  166 LEU A HD22 1 
ATOM   1355 H HD23 . LEU A 1 85  ? 23.74890  -6.31030  -3.99860  1.000 18.74889  ?  166 LEU A HD23 1 
ATOM   1356 N N    . PRO A 1 86  ? 22.26119  -2.91871  -2.42179  1.000 12.47000  ?  167 PRO A N    1 
ATOM   1357 C CA   . PRO A 1 86  ? 22.25016  -1.58130  -1.80497  1.000 12.65970  ?  167 PRO A CA   1 
ATOM   1358 C C    . PRO A 1 86  ? 22.72258  -0.51974  -2.78480  1.000 13.57290  ?  167 PRO A C    1 
ATOM   1359 O O    . PRO A 1 86  ? 23.60703  -0.76362  -3.60440  1.000 15.46024  ?  167 PRO A O    1 
ATOM   1360 C CB   . PRO A 1 86  ? 23.24538  -1.72117  -0.64905  1.000 14.78483  ?  167 PRO A CB   1 
ATOM   1361 C CG   . PRO A 1 86  ? 23.65718  -3.10848  -0.55163  1.000 19.44691  ?  167 PRO A CG   1 
ATOM   1362 C CD   . PRO A 1 86  ? 23.29845  -3.79809  -1.85136  1.000 12.23522  ?  167 PRO A CD   1 
ATOM   1363 H HA   . PRO A 1 86  ? 21.25542  -1.33914  -1.43088  1.000 15.19164  ?  167 PRO A HA   1 
ATOM   1364 H HB2  . PRO A 1 86  ? 24.10951  -1.08734  -0.84818  1.000 17.74180  ?  167 PRO A HB2  1 
ATOM   1365 H HB3  . PRO A 1 86  ? 22.75933  -1.40921  0.27536   1.000 17.74180  ?  167 PRO A HB3  1 
ATOM   1366 H HG2  . PRO A 1 86  ? 24.73390  -3.15085  -0.38739  1.000 23.33629  ?  167 PRO A HG2  1 
ATOM   1367 H HG3  . PRO A 1 86  ? 23.13424  -3.57872  0.28114   1.000 23.33629  ?  167 PRO A HG3  1 
ATOM   1368 H HD2  . PRO A 1 86  ? 24.16373  -3.85747  -2.51155  1.000 14.68226  ?  167 PRO A HD2  1 
ATOM   1369 H HD3  . PRO A 1 86  ? 22.90233  -4.79637  -1.66524  1.000 14.68226  ?  167 PRO A HD3  1 
ATOM   1370 N N    . ASP A 1 87  ? 22.12877  0.67227   -2.68195  1.000 13.26627  ?  168 ASP A N    1 
ATOM   1371 C CA   . ASP A 1 87  ? 22.41484  1.73812   -3.65300  1.000 13.77387  ?  168 ASP A CA   1 
ATOM   1372 C C    . ASP A 1 87  ? 22.21451  1.20930   -5.07943  1.000 13.11805  ?  168 ASP A C    1 
ATOM   1373 O O    . ASP A 1 87  ? 23.01838  1.46290   -5.97879  1.000 14.03428  ?  168 ASP A O    1 
ATOM   1374 C CB   . ASP A 1 87  ? 23.81073  2.34251   -3.45581  1.000 15.06916  ?  168 ASP A CB   1 
ATOM   1375 C CG   . ASP A 1 87  ? 23.90226  3.28950   -2.24405  1.000 17.68405  ?  168 ASP A CG   1 
ATOM   1376 O OD1  . ASP A 1 87  ? 23.08992  3.18612   -1.29777  1.000 17.73943  ?  168 ASP A OD1  1 
ATOM   1377 O OD2  . ASP A 1 87  ? 24.80349  4.14874   -2.28438  1.000 22.42364  -1 168 ASP A OD2  1 
ATOM   1378 H H    A ASP A 1 87  ? 21.46011  0.92679   -1.95497  0.440 15.91952  ?  168 ASP A H    1 
ATOM   1379 D D    B ASP A 1 87  ? 21.46016  0.92618   -1.95470  0.560 15.91952  ?  168 ASP A D    1 
ATOM   1380 H HA   . ASP A 1 87  ? 21.71173  2.55551   -3.49297  1.000 16.52864  ?  168 ASP A HA   1 
ATOM   1381 H HB2  . ASP A 1 87  ? 24.52616  1.53450   -3.30290  1.000 18.08299  ?  168 ASP A HB2  1 
ATOM   1382 H HB3  . ASP A 1 87  ? 24.07682  2.91258   -4.34593  1.000 18.08299  ?  168 ASP A HB3  1 
ATOM   1383 N N    . ARG A 1 88  ? 21.13500  0.46473   -5.26071  1.000 13.98376  ?  169 ARG A N    1 
ATOM   1384 C CA   . ARG A 1 88  ? 20.81095  -0.16516  -6.54409  1.000 12.66938  ?  169 ARG A CA   1 
ATOM   1385 C C    . ARG A 1 88  ? 20.73854  0.87047   -7.65808  1.000 14.73257  ?  169 ARG A C    1 
ATOM   1386 O O    . ARG A 1 88  ? 20.29762  2.01171   -7.43901  1.000 15.94750  ?  169 ARG A O    1 
ATOM   1387 C CB   . ARG A 1 88  ? 19.45182  -0.84102  -6.40758  1.000 13.02531  ?  169 ARG A CB   1 
ATOM   1388 C CG   . ARG A 1 88  ? 19.33513  -2.10925  -7.24814  1.000 13.09848  ?  169 ARG A CG   1 
ATOM   1389 C CD   . ARG A 1 88  ? 18.01044  -2.79965  -7.00930  1.000 13.17650  ?  169 ARG A CD   1 
ATOM   1390 N NE   . ARG A 1 88  ? 16.90989  -2.01084  -7.53612  1.000 14.48383  ?  169 ARG A NE   1 
ATOM   1391 C CZ   . ARG A 1 88  ? 15.63604  -2.24820  -7.28517  1.000 15.42452  ?  169 ARG A CZ   1 
ATOM   1392 N NH1  . ARG A 1 88  ? 15.26204  -3.25463  -6.50340  1.000 15.91519  ?  169 ARG A NH1  1 
ATOM   1393 N NH2  . ARG A 1 88  ? 14.71225  -1.44430  -7.83162  1.000 18.18995  ?  169 ARG A NH2  1 
ATOM   1394 H H    A ARG A 1 88  ? 20.44810  0.26998   -4.53226  0.100 16.78052  ?  169 ARG A H    1 
ATOM   1395 D D    B ARG A 1 88  ? 20.44712  0.26896   -4.53346  0.900 16.78052  ?  169 ARG A D    1 
ATOM   1396 H HA   . ARG A 1 88  ? 21.57727  -0.89283  -6.81119  1.000 15.20325  ?  169 ARG A HA   1 
ATOM   1397 H HB2  . ARG A 1 88  ? 19.29405  -1.11240  -5.36376  1.000 15.63037  ?  169 ARG A HB2  1 
ATOM   1398 H HB3  . ARG A 1 88  ? 18.67667  -0.14758  -6.73375  1.000 15.63037  ?  169 ARG A HB3  1 
ATOM   1399 H HG2  . ARG A 1 88  ? 19.40398  -1.85179  -8.30506  1.000 15.71818  ?  169 ARG A HG2  1 
ATOM   1400 H HG3  . ARG A 1 88  ? 20.13611  -2.79789  -6.97924  1.000 15.71818  ?  169 ARG A HG3  1 
ATOM   1401 H HD2  . ARG A 1 88  ? 18.01081  -3.76850  -7.50873  1.000 15.81180  ?  169 ARG A HD2  1 
ATOM   1402 H HD3  . ARG A 1 88  ? 17.85825  -2.93244  -5.93818  1.000 15.81180  ?  169 ARG A HD3  1 
ATOM   1403 H HE   A ARG A 1 88  ? 17.13685  -1.22092  -8.14020  0.220 17.38060  ?  169 ARG A HE   1 
ATOM   1404 D DE   B ARG A 1 88  ? 17.13685  -1.22092  -8.14020  0.780 17.38060  ?  169 ARG A DE   1 
ATOM   1405 H HH11 A ARG A 1 88  ? 15.96510  -3.86260  -6.08331  0.130 19.09823  ?  169 ARG A HH11 1 
ATOM   1406 D DH11 B ARG A 1 88  ? 15.96510  -3.86260  -6.08331  0.870 19.09823  ?  169 ARG A DH11 1 
ATOM   1407 H HH12 A ARG A 1 88  ? 14.27175  -3.41959  -6.32310  0.260 19.09823  ?  169 ARG A HH12 1 
ATOM   1408 D DH12 B ARG A 1 88  ? 14.27175  -3.41959  -6.32310  0.740 19.09823  ?  169 ARG A DH12 1 
ATOM   1409 H HH21 A ARG A 1 88  ? 14.99992  -0.66810  -8.42759  0.290 21.82794  ?  169 ARG A HH21 1 
ATOM   1410 D DH21 B ARG A 1 88  ? 14.99992  -0.66810  -8.42759  0.710 21.82794  ?  169 ARG A DH21 1 
ATOM   1411 H HH22 A ARG A 1 88  ? 13.72192  -1.60901  -7.65131  0.300 21.82794  ?  169 ARG A HH22 1 
ATOM   1412 D DH22 B ARG A 1 88  ? 13.72192  -1.60901  -7.65131  0.700 21.82794  ?  169 ARG A DH22 1 
ATOM   1413 N N    . ASP A 1 89  ? 21.10821  0.45306   -8.86661  1.000 12.44422  ?  170 ASP A N    1 
ATOM   1414 C CA   . ASP A 1 89  ? 20.95311  1.30127   -10.05845 1.000 11.82432  ?  170 ASP A CA   1 
ATOM   1415 C C    . ASP A 1 89  ? 21.70887  2.61314   -9.89641  1.000 14.35465  ?  170 ASP A C    1 
ATOM   1416 O O    . ASP A 1 89  ? 21.14779  3.70100   -10.06689 1.000 14.97574  ?  170 ASP A O    1 
ATOM   1417 C CB   . ASP A 1 89  ? 19.47481  1.52428   -10.38080 1.000 11.90185  ?  170 ASP A CB   1 
ATOM   1418 C CG   . ASP A 1 89  ? 18.68610  0.25806   -10.37610 1.000 13.32177  ?  170 ASP A CG   1 
ATOM   1419 O OD1  . ASP A 1 89  ? 18.88815  -0.57542  -11.29347 1.000 14.74575  ?  170 ASP A OD1  1 
ATOM   1420 O OD2  . ASP A 1 89  ? 17.88542  0.08340   -9.43311  1.000 15.39484  -1 170 ASP A OD2  1 
ATOM   1421 H H    A ASP A 1 89  ? 21.51678  -0.46183  -9.05754  0.030 14.93307  ?  170 ASP A H    1 
ATOM   1422 D D    B ASP A 1 89  ? 21.51670  -0.46210  -9.05640  0.970 14.93307  ?  170 ASP A D    1 
ATOM   1423 H HA   . ASP A 1 89  ? 21.39499  0.79049   -10.91399 1.000 14.18919  ?  170 ASP A HA   1 
ATOM   1424 H HB2  . ASP A 1 89  ? 19.04512  2.19185   -9.63394  1.000 14.28222  ?  170 ASP A HB2  1 
ATOM   1425 H HB3  . ASP A 1 89  ? 19.39065  1.97017   -11.37186 1.000 14.28222  ?  170 ASP A HB3  1 
ATOM   1426 N N    . CYS A 1 90  ? 23.02055  2.52055   -9.63177  1.000 13.00579  ?  171 CYS A N    1 
ATOM   1427 C CA   A CYS A 1 90  ? 23.76228  3.69752   -9.17755  0.720 12.56763  ?  171 CYS A CA   1 
ATOM   1428 C CA   B CYS A 1 90  ? 23.77272  3.68712   -9.17628  0.280 12.68239  ?  171 CYS A CA   1 
ATOM   1429 C C    . CYS A 1 90  ? 23.78731  4.82411   -10.20281 1.000 14.40805  ?  171 CYS A C    1 
ATOM   1430 O O    . CYS A 1 90  ? 23.98618  5.98974   -9.82072  1.000 17.86718  ?  171 CYS A O    1 
ATOM   1431 C CB   A CYS A 1 90  ? 25.18765  3.32756   -8.80368  0.720 14.42951  ?  171 CYS A CB   1 
ATOM   1432 C CB   B CYS A 1 90  ? 25.19909  3.28667   -8.80882  0.280 14.46244  ?  171 CYS A CB   1 
ATOM   1433 S SG   A CYS A 1 90  ? 26.13084  2.50176   -10.08956 0.720 14.31810  ?  171 CYS A SG   1 
ATOM   1434 S SG   B CYS A 1 90  ? 26.13510  2.48858   -10.13106 0.280 14.38462  ?  171 CYS A SG   1 
ATOM   1435 H H    A CYS A 1 90  ? 23.57744  1.67058   -9.72026  0.180 15.60694  ?  171 CYS A H    1 
ATOM   1436 D D    B CYS A 1 90  ? 23.57706  1.67046   -9.72141  0.820 15.60694  ?  171 CYS A D    1 
ATOM   1437 H HA   A CYS A 1 90  ? 23.26067  4.06891   -8.28393  0.720 15.08116  ?  171 CYS A HA   1 
ATOM   1438 H HA   B CYS A 1 90  ? 23.28217  4.06869   -8.28082  0.280 15.21887  ?  171 CYS A HA   1 
ATOM   1439 H HB2  A CYS A 1 90  ? 25.72249  4.24114   -8.54403  0.720 17.31541  ?  171 CYS A HB2  1 
ATOM   1440 H HB2  B CYS A 1 90  ? 25.74489  4.18436   -8.51838  0.280 17.35493  ?  171 CYS A HB2  1 
ATOM   1441 H HB3  A CYS A 1 90  ? 25.15425  2.65805   -7.94418  0.720 17.31541  ?  171 CYS A HB3  1 
ATOM   1442 H HB3  B CYS A 1 90  ? 25.15638  2.58929   -7.97221  0.280 17.35493  ?  171 CYS A HB3  1 
ATOM   1443 N N    . ALA A 1 91  ? 23.62766  4.53578   -11.49017 1.000 14.31749  ?  172 ALA A N    1 
ATOM   1444 C CA   . ALA A 1 91  ? 23.72917  5.58015   -12.50544 1.000 15.12538  ?  172 ALA A CA   1 
ATOM   1445 C C    . ALA A 1 91  ? 22.37559  6.11306   -12.93159 1.000 18.63350  ?  172 ALA A C    1 
ATOM   1446 O O    . ALA A 1 91  ? 22.30511  6.97076   -13.81903 1.000 21.53232  ?  172 ALA A O    1 
ATOM   1447 C CB   . ALA A 1 91  ? 24.49179  5.08451   -13.72748 1.000 17.44480  ?  172 ALA A CB   1 
ATOM   1448 H H    A ALA A 1 91  ? 23.43037  3.60400   -11.85523 0.060 17.18098  ?  172 ALA A H    1 
ATOM   1449 D D    B ALA A 1 91  ? 23.43039  3.60345   -11.85383 0.940 17.18098  ?  172 ALA A D    1 
ATOM   1450 H HA   . ALA A 1 91  ? 24.30340  6.40523   -12.08401 1.000 18.15045  ?  172 ALA A HA   1 
ATOM   1451 H HB1  . ALA A 1 91  ? 24.43541  5.83979   -14.51136 1.000 20.93376  ?  172 ALA A HB1  1 
ATOM   1452 H HB2  . ALA A 1 91  ? 25.53205  4.91269   -13.45098 1.000 20.93376  ?  172 ALA A HB2  1 
ATOM   1453 H HB3  . ALA A 1 91  ? 24.04087  4.15466   -14.07412 1.000 20.93376  ?  172 ALA A HB3  1 
ATOM   1454 N N    . ALA A 1 92  ? 21.29918  5.62573   -12.35326 1.000 17.86494  ?  173 ALA A N    1 
ATOM   1455 C CA   . ALA A 1 92  ? 19.96112  6.01947   -12.75641 1.000 18.64785  ?  173 ALA A CA   1 
ATOM   1456 C C    . ALA A 1 92  ? 19.57755  7.30172   -12.02345 1.000 26.23059  ?  173 ALA A C    1 
ATOM   1457 O O    . ALA A 1 92  ? 20.10492  7.60807   -10.95481 1.000 24.18100  ?  173 ALA A O    1 
ATOM   1458 C CB   . ALA A 1 92  ? 18.96169  4.91478   -12.43422 1.000 18.32877  ?  173 ALA A CB   1 
ATOM   1459 H H    A ALA A 1 92  ? 21.31657  4.94712   -11.59196 0.030 21.43793  ?  173 ALA A H    1 
ATOM   1460 D D    B ALA A 1 92  ? 21.31726  4.94712   -11.59197 0.970 21.43793  ?  173 ALA A D    1 
ATOM   1461 H HA   . ALA A 1 92  ? 19.92526  6.19630   -13.83137 1.000 22.37742  ?  173 ALA A HA   1 
ATOM   1462 H HB1  . ALA A 1 92  ? 17.96896  5.35312   -12.33200 1.000 21.99452  ?  173 ALA A HB1  1 
ATOM   1463 H HB2  . ALA A 1 92  ? 18.96460  4.18611   -13.24485 1.000 21.99452  ?  173 ALA A HB2  1 
ATOM   1464 H HB3  . ALA A 1 92  ? 19.25341  4.43350   -11.50075 1.000 21.99452  ?  173 ALA A HB3  1 
ATOM   1465 N N    . LYS A 1 93  ? 18.61474  8.04278   -12.61353 1.000 24.10523  ?  174 LYS A N    1 
ATOM   1466 C CA   . LYS A 1 93  ? 18.13063  9.27480   -11.99360 1.000 25.87747  ?  174 LYS A CA   1 
ATOM   1467 C C    . LYS A 1 93  ? 17.28091  8.98474   -10.76381 1.000 33.94809  ?  174 LYS A C    1 
ATOM   1468 O O    . LYS A 1 93  ? 17.24636  9.79287   -9.82901  1.000 37.01008  ?  174 LYS A O    1 
ATOM   1469 C CB   . LYS A 1 93  ? 17.36878  10.10638  -13.03132 1.000 28.35609  ?  174 LYS A CB   1 
ATOM   1470 C CG   . LYS A 1 93  ? 18.25820  10.50551  -14.21742 1.000 33.78451  ?  174 LYS A CG   1 
ATOM   1471 C CD   . LYS A 1 93  ? 17.58850  11.46758  -15.19397 1.000 53.57411  ?  174 LYS A CD   1 
ATOM   1472 C CE   . LYS A 1 93  ? 17.52399  12.90260  -14.65665 1.000 74.13698  ?  174 LYS A CE   1 
ATOM   1473 N NZ   . LYS A 1 93  ? 17.16309  13.90775  -15.72362 1.000 73.81222  ?  174 LYS A NZ   1 
ATOM   1474 H H    A LYS A 1 93  ? 18.16626  7.81396   -13.50061 0.000 28.92627  ?  174 LYS A H    1 
ATOM   1475 D D    B LYS A 1 93  ? 18.16478  7.81614   -13.50042 1.000 28.92627  ?  174 LYS A D    1 
ATOM   1476 H HA   . LYS A 1 93  ? 18.97625  9.87479   -11.65739 1.000 31.05296  ?  174 LYS A HA   1 
ATOM   1477 H HB2  . LYS A 1 93  ? 16.53255  9.52140   -13.41424 1.000 34.02731  ?  174 LYS A HB2  1 
ATOM   1478 H HB3  . LYS A 1 93  ? 17.00119  11.01755  -12.55936 1.000 34.02731  ?  174 LYS A HB3  1 
ATOM   1479 H HG2  . LYS A 1 93  ? 19.15533  10.99247  -13.83516 1.000 40.54141  ?  174 LYS A HG2  1 
ATOM   1480 H HG3  . LYS A 1 93  ? 18.52913  9.60654   -14.77110 1.000 40.54141  ?  174 LYS A HG3  1 
ATOM   1481 H HD2  . LYS A 1 93  ? 18.15451  11.48124  -16.12539 1.000 64.28893  ?  174 LYS A HD2  1 
ATOM   1482 H HD3  . LYS A 1 93  ? 16.56878  11.13171  -15.38228 1.000 64.28893  ?  174 LYS A HD3  1 
ATOM   1483 H HE2  . LYS A 1 93  ? 16.76755  12.95569  -13.87366 1.000 88.96437  ?  174 LYS A HE2  1 
ATOM   1484 H HE3  . LYS A 1 93  ? 18.49881  13.17532  -14.25235 1.000 88.96437  ?  174 LYS A HE3  1 
ATOM   1485 N N    . ALA A 1 94  ? 16.62171  7.83429   -10.72020 1.000 27.19262  ?  175 ALA A N    1 
ATOM   1486 C CA   . ALA A 1 94  ? 15.82408  7.45012   -9.57110  1.000 32.82783  ?  175 ALA A CA   1 
ATOM   1487 C C    . ALA A 1 94  ? 15.97349  5.94679   -9.38047  1.000 27.19637  ?  175 ALA A C    1 
ATOM   1488 O O    . ALA A 1 94  ? 16.07314  5.20394   -10.36595 1.000 34.40470  ?  175 ALA A O    1 
ATOM   1489 C CB   . ALA A 1 94  ? 14.34873  7.77592   -9.83212  1.000 33.20061  ?  175 ALA A CB   1 
ATOM   1490 H H    A ALA A 1 94  ? 16.62284  7.14507   -11.47211 0.090 32.63115  ?  175 ALA A H    1 
ATOM   1491 D D    B ALA A 1 94  ? 16.62359  7.14580   -11.47278 0.910 32.63115  ?  175 ALA A D    1 
ATOM   1492 H HA   . ALA A 1 94  ? 16.15686  7.96407   -8.66931  1.000 39.39340  ?  175 ALA A HA   1 
ATOM   1493 H HB1  . ALA A 1 94  ? 14.24070  8.85274   -9.96203  1.000 39.84073  ?  175 ALA A HB1  1 
ATOM   1494 H HB2  . ALA A 1 94  ? 14.02540  7.25828   -10.73523 1.000 39.84073  ?  175 ALA A HB2  1 
ATOM   1495 H HB3  . ALA A 1 94  ? 13.75569  7.44294   -8.98034  1.000 39.84073  ?  175 ALA A HB3  1 
ATOM   1496 N N    . SER A 1 95  ? 16.00074  5.49423   -8.13120  1.000 29.69491  ?  176 SER A N    1 
ATOM   1497 C CA   . SER A 1 95  ? 16.04327  4.06033   -7.85227  1.000 37.68017  ?  176 SER A CA   1 
ATOM   1498 C C    . SER A 1 95  ? 14.99088  3.68720   -6.83268  1.000 27.59909  ?  176 SER A C    1 
ATOM   1499 O O    . SER A 1 95  ? 14.78716  4.39909   -5.85089  1.000 34.89315  ?  176 SER A O    1 
ATOM   1500 C CB   . SER A 1 95  ? 17.39582  3.53299   -7.32338  1.000 44.57066  ?  176 SER A CB   1 
ATOM   1501 O OG   . SER A 1 95  ? 17.31297  2.10260   -7.19913  1.000 32.47550  ?  176 SER A OG   1 
ATOM   1502 H H    A SER A 1 95  ? 15.99440  6.08761   -7.30158  0.210 35.63390  ?  176 SER A H    1 
ATOM   1503 D D    B SER A 1 95  ? 15.99434  6.08911   -7.30265  0.790 35.63390  ?  176 SER A D    1 
ATOM   1504 H HA   . SER A 1 95  ? 15.84778  3.57682   -8.80941  1.000 45.21621  ?  176 SER A HA   1 
ATOM   1505 H HB2  . SER A 1 95  ? 18.18842  3.79304   -8.02499  1.000 53.48479  ?  176 SER A HB2  1 
ATOM   1506 H HB3  . SER A 1 95  ? 17.60258  3.97268   -6.34767  1.000 53.48479  ?  176 SER A HB3  1 
ATOM   1507 N N    . ASN A 1 96  ? 14.34707  2.55261   -7.06462  1.000 28.49942  ?  177 ASN A N    1 
ATOM   1508 C CA   . ASN A 1 96  ? 13.35259  2.00253   -6.15219  1.000 31.66392  ?  177 ASN A CA   1 
ATOM   1509 C C    . ASN A 1 96  ? 13.95912  1.00574   -5.15920  1.000 27.81705  ?  177 ASN A C    1 
ATOM   1510 O O    . ASN A 1 96  ? 13.20980  0.33266   -4.44083  1.000 31.02866  ?  177 ASN A O    1 
ATOM   1511 C CB   . ASN A 1 96  ? 12.23852  1.30032   -6.94719  1.000 34.22446  ?  177 ASN A CB   1 
ATOM   1512 C CG   . ASN A 1 96  ? 11.31897  2.29068   -7.69899  1.000 64.44122  ?  177 ASN A CG   1 
ATOM   1513 O OD1  . ASN A 1 96  ? 10.37082  2.81268   -7.11517  1.000 67.96417  ?  177 ASN A OD1  1 
ATOM   1514 N ND2  . ASN A 1 96  ? 11.58662  2.52709   -8.99785  1.000 41.73939  ?  177 ASN A ND2  1 
ATOM   1515 H H    A ASN A 1 96  ? 14.49485  1.97771   -7.89410  0.230 34.19930  ?  177 ASN A H    1 
ATOM   1516 D D    B ASN A 1 96  ? 14.49595  1.97876   -7.89464  0.770 34.19930  ?  177 ASN A D    1 
ATOM   1517 H HA   . ASN A 1 96  ? 12.90890  2.82486   -5.59094  1.000 37.99670  ?  177 ASN A HA   1 
ATOM   1518 H HB2  . ASN A 1 96  ? 12.69253  0.63758   -7.68390  1.000 41.06935  ?  177 ASN A HB2  1 
ATOM   1519 H HB3  . ASN A 1 96  ? 11.62054  0.72439   -6.25835  1.000 41.06935  ?  177 ASN A HB3  1 
ATOM   1520 N N    . GLY A 1 97  ? 15.28329  0.87126   -5.11442  1.000 22.75406  ?  178 GLY A N    1 
ATOM   1521 C CA   . GLY A 1 97  ? 15.88163  -0.11025  -4.23090  1.000 18.55615  ?  178 GLY A CA   1 
ATOM   1522 C C    . GLY A 1 97  ? 15.70751  0.25759   -2.76217  1.000 21.92838  ?  178 GLY A C    1 
ATOM   1523 O O    . GLY A 1 97  ? 15.89326  1.40298   -2.34985  1.000 24.55496  ?  178 GLY A O    1 
ATOM   1524 H H    A GLY A 1 97  ? 15.94758  1.41516   -5.66514  0.110 27.30488  ?  178 GLY A H    1 
ATOM   1525 D D    B GLY A 1 97  ? 15.94954  1.41386   -5.66405  0.890 27.30488  ?  178 GLY A D    1 
ATOM   1526 H HA2  . GLY A 1 97  ? 15.41637  -1.08132  -4.40023  1.000 22.26737  ?  178 GLY A HA2  1 
ATOM   1527 H HA3  . GLY A 1 97  ? 16.94813  -0.18594  -4.44288  1.000 22.26737  ?  178 GLY A HA3  1 
ATOM   1528 N N    . GLU A 1 98  ? 15.35974  -0.74209  -1.95881  1.000 17.62326  ?  179 GLU A N    1 
ATOM   1529 C CA   . GLU A 1 98  ? 15.08856  -0.50067  -0.54084  1.000 17.74663  ?  179 GLU A CA   1 
ATOM   1530 C C    . GLU A 1 98  ? 16.31793  -0.41798  0.35416   1.000 18.91082  ?  179 GLU A C    1 
ATOM   1531 O O    . GLU A 1 98  ? 16.19558  0.07510   1.48883   1.000 21.03556  ?  179 GLU A O    1 
ATOM   1532 C CB   . GLU A 1 98  ? 14.16749  -1.57781  0.00138   1.000 17.39927  ?  179 GLU A CB   1 
ATOM   1533 C CG   . GLU A 1 98  ? 14.76912  -2.94230  0.03952   1.000 18.19915  ?  179 GLU A CG   1 
ATOM   1534 C CD   . GLU A 1 98  ? 13.79213  -4.05983  0.31408   1.000 20.00840  ?  179 GLU A CD   1 
ATOM   1535 O OE1  . GLU A 1 98  ? 12.69625  -3.81009  0.87559   1.000 25.16308  ?  179 GLU A OE1  1 
ATOM   1536 O OE2  . GLU A 1 98  ? 14.10101  -5.22570  -0.00956  1.000 15.54727  -1 179 GLU A OE2  1 
ATOM   1537 H H    A GLU A 1 98  ? 15.25795  -1.71418  -2.25047  0.280 21.14791  ?  179 GLU A H    1 
ATOM   1538 D D    B GLU A 1 98  ? 15.25769  -1.71445  -2.24949  0.720 21.14791  ?  179 GLU A D    1 
ATOM   1539 H HA   . GLU A 1 98  ? 14.59583  0.46980   -0.48170  1.000 21.29595  ?  179 GLU A HA   1 
ATOM   1540 H HB2  . GLU A 1 98  ? 13.88576  -1.31327  1.02057   1.000 20.87912  ?  179 GLU A HB2  1 
ATOM   1541 H HB3  . GLU A 1 98  ? 13.28027  -1.62638  -0.62996  1.000 20.87912  ?  179 GLU A HB3  1 
ATOM   1542 H HG2  . GLU A 1 98  ? 15.23248  -3.14322  -0.92641  1.000 21.83898  ?  179 GLU A HG2  1 
ATOM   1543 H HG3  . GLU A 1 98  ? 15.52271  -2.96625  0.82669   1.000 21.83898  ?  179 GLU A HG3  1 
ATOM   1544 N N    . PHE A 1 99  ? 17.49703  -0.85175  -0.07140  1.000 15.39739  ?  180 PHE A N    1 
ATOM   1545 C CA   . PHE A 1 99  ? 18.64988  -0.84035  0.82456   1.000 14.54771  ?  180 PHE A CA   1 
ATOM   1546 C C    . PHE A 1 99  ? 19.63336  0.24611   0.41960   1.000 16.17750  ?  180 PHE A C    1 
ATOM   1547 O O    . PHE A 1 99  ? 19.78855  0.58514   -0.76718  1.000 16.14005  ?  180 PHE A O    1 
ATOM   1548 C CB   . PHE A 1 99  ? 19.38313  -2.18374  0.81248   1.000 15.28322  ?  180 PHE A CB   1 
ATOM   1549 C CG   . PHE A 1 99  ? 18.58578  -3.34729  1.31042   1.000 15.32519  ?  180 PHE A CG   1 
ATOM   1550 C CD1  . PHE A 1 99  ? 17.75594  -3.23626  2.39960   1.000 18.53854  ?  180 PHE A CD1  1 
ATOM   1551 C CD2  . PHE A 1 99  ? 18.69721  -4.59731  0.68138   1.000 16.14219  ?  180 PHE A CD2  1 
ATOM   1552 C CE1  . PHE A 1 99  ? 17.05353  -4.33068  2.84474   1.000 17.92141  ?  180 PHE A CE1  1 
ATOM   1553 C CE2  . PHE A 1 99  ? 17.97801  -5.67394  1.12927   1.000 16.44827  ?  180 PHE A CE2  1 
ATOM   1554 C CZ   . PHE A 1 99  ? 17.16678  -5.54543  2.20214   1.000 18.24497  ?  180 PHE A CZ   1 
ATOM   1555 H H    A PHE A 1 99  ? 17.68213  -1.20882  -1.00876  0.050 18.47687  ?  180 PHE A H    1 
ATOM   1556 D D    B PHE A 1 99  ? 17.68016  -1.20850  -1.00927  0.950 18.47687  ?  180 PHE A D    1 
ATOM   1557 H HA   . PHE A 1 99  ? 18.29521  -0.63833  1.83525   1.000 17.45725  ?  180 PHE A HA   1 
ATOM   1558 H HB2  . PHE A 1 99  ? 19.67840  -2.40578  -0.21300  1.000 18.33987  ?  180 PHE A HB2  1 
ATOM   1559 H HB3  . PHE A 1 99  ? 20.26685  -2.09951  1.44496   1.000 18.33987  ?  180 PHE A HB3  1 
ATOM   1560 H HD1  . PHE A 1 99  ? 17.65536  -2.28800  2.90665   1.000 22.24625  ?  180 PHE A HD1  1 
ATOM   1561 H HD2  . PHE A 1 99  ? 19.35759  -4.71162  -0.16552  1.000 19.37063  ?  180 PHE A HD2  1 
ATOM   1562 H HE1  . PHE A 1 99  ? 16.40739  -4.23838  3.70519   1.000 21.50570  ?  180 PHE A HE1  1 
ATOM   1563 H HE2  . PHE A 1 99  ? 18.05950  -6.62539  0.62479   1.000 19.73792  ?  180 PHE A HE2  1 
ATOM   1564 H HZ   . PHE A 1 99  ? 16.60529  -6.39681  2.55750   1.000 21.89396  ?  180 PHE A HZ   1 
ATOM   1565 N N    . SER A 1 100 ? 20.32244  0.80527   1.40974   1.000 16.85520  ?  181 SER A N    1 
ATOM   1566 C CA   . SER A 1 100 ? 21.33355  1.82918   1.15139   1.000 15.78027  ?  181 SER A CA   1 
ATOM   1567 C C    . SER A 1 100 ? 22.64668  1.44013   1.80532   1.000 17.00219  ?  181 SER A C    1 
ATOM   1568 O O    . SER A 1 100 ? 22.65606  0.87151   2.90106   1.000 17.49428  ?  181 SER A O    1 
ATOM   1569 C CB   . SER A 1 100 ? 20.92205  3.21089   1.67077   1.000 23.21299  ?  181 SER A CB   1 
ATOM   1570 O OG   . SER A 1 100 ? 20.75511  3.16817   3.05848   1.000 33.21674  ?  181 SER A OG   1 
ATOM   1571 H H    A SER A 1 100 ? 20.20427  0.57197   2.39565   0.060 20.22624  ?  181 SER A H    1 
ATOM   1572 D D    B SER A 1 100 ? 20.20295  0.57073   2.39519   0.940 20.22624  ?  181 SER A D    1 
ATOM   1573 H HA   . SER A 1 100 ? 21.47261  1.89432   0.07226   1.000 18.93632  ?  181 SER A HA   1 
ATOM   1574 H HB2  . SER A 1 100 ? 21.70051  3.93317   1.42499   1.000 27.85559  ?  181 SER A HB2  1 
ATOM   1575 H HB3  . SER A 1 100 ? 19.98117  3.50384   1.20493   1.000 27.85559  ?  181 SER A HB3  1 
ATOM   1576 N N    . ILE A 1 101 ? 23.74989  1.76112   1.14700   1.000 16.04334  ?  182 ILE A N    1 
ATOM   1577 C CA   . ILE A 1 101 ? 25.05488  1.40465   1.69153   1.000 17.33958  ?  182 ILE A CA   1 
ATOM   1578 C C    . ILE A 1 101 ? 25.22622  2.02113   3.06513   1.000 22.69140  ?  182 ILE A C    1 
ATOM   1579 O O    . ILE A 1 101 ? 25.68541  1.35781   3.99924   1.000 22.45594  ?  182 ILE A O    1 
ATOM   1580 C CB   . ILE A 1 101 ? 26.18234  1.81718   0.73973   1.000 17.03012  ?  182 ILE A CB   1 
ATOM   1581 C CG1  . ILE A 1 101 ? 26.14018  0.93039   -0.50184  1.000 20.29631  ?  182 ILE A CG1  1 
ATOM   1582 C CG2  . ILE A 1 101 ? 27.52099  1.65497   1.42320   1.000 21.66335  ?  182 ILE A CG2  1 
ATOM   1583 C CD1  . ILE A 1 101 ? 27.14891  1.31521   -1.55960  1.000 21.05542  ?  182 ILE A CD1  1 
ATOM   1584 H H    A ILE A 1 101 ? 23.77767  2.25595   0.25550   0.090 19.25200  ?  182 ILE A H    1 
ATOM   1585 D D    B ILE A 1 101 ? 23.77998  2.25584   0.25551   0.910 19.25200  ?  182 ILE A D    1 
ATOM   1586 H HA   . ILE A 1 101 ? 25.10044  0.32016   1.79104   1.000 20.80750  ?  182 ILE A HA   1 
ATOM   1587 H HB   . ILE A 1 101 ? 26.04619  2.86110   0.45728   1.000 20.43614  ?  182 ILE A HB   1 
ATOM   1588 H HG12 . ILE A 1 101 ? 26.34537  -0.09814  -0.20500  1.000 24.35557  ?  182 ILE A HG12 1 
ATOM   1589 H HG13 . ILE A 1 101 ? 25.14796  0.99881   -0.94783  1.000 24.35557  ?  182 ILE A HG13 1 
ATOM   1590 H HG21 . ILE A 1 101 ? 28.16449  2.48991   1.14592   1.000 25.99602  ?  182 ILE A HG21 1 
ATOM   1591 H HG22 . ILE A 1 101 ? 27.36945  1.64498   2.50257   1.000 25.99602  ?  182 ILE A HG22 1 
ATOM   1592 H HG23 . ILE A 1 101 ? 27.97172  0.71580   1.10243   1.000 25.99602  ?  182 ILE A HG23 1 
ATOM   1593 H HD11 . ILE A 1 101 ? 26.62115  1.55546   -2.48256  1.000 25.26650  ?  182 ILE A HD11 1 
ATOM   1594 H HD12 . ILE A 1 101 ? 27.71015  2.18391   -1.21542  1.000 25.26650  ?  182 ILE A HD12 1 
ATOM   1595 H HD13 . ILE A 1 101 ? 27.82593  0.47730   -1.72587  1.000 25.26650  ?  182 ILE A HD13 1 
ATOM   1596 N N    . ALA A 1 102 ? 24.77280  3.26802   3.22000   1.000 21.49948  ?  183 ALA A N    1 
ATOM   1597 C CA   . ALA A 1 102 ? 24.98579  4.00165   4.46266   1.000 23.10437  ?  183 ALA A CA   1 
ATOM   1598 C C    . ALA A 1 102 ? 24.13704  3.49323   5.61815   1.000 27.50821  ?  183 ALA A C    1 
ATOM   1599 O O    . ALA A 1 102 ? 24.44222  3.83195   6.77103   1.000 31.99033  ?  183 ALA A O    1 
ATOM   1600 C CB   . ALA A 1 102 ? 24.69338  5.47341   4.20249   1.000 24.57183  ?  183 ALA A CB   1 
ATOM   1601 H H    A ALA A 1 102 ? 24.25994  3.79001   2.50943   0.000 25.79938  ?  183 ALA A H    1 
ATOM   1602 D D    B ALA A 1 102 ? 24.25982  3.79146   2.51059   1.000 25.79938  ?  183 ALA A D    1 
ATOM   1603 H HA   . ALA A 1 102 ? 26.02397  3.88717   4.77438   1.000 27.72524  ?  183 ALA A HA   1 
ATOM   1604 H HB1  . ALA A 1 102 ? 23.62775  5.65387   4.34379   1.000 29.48620  ?  183 ALA A HB1  1 
ATOM   1605 H HB2  . ALA A 1 102 ? 25.26894  6.07875   4.90276   1.000 29.48620  ?  183 ALA A HB2  1 
ATOM   1606 H HB3  . ALA A 1 102 ? 24.97903  5.71645   3.17905   1.000 29.48620  ?  183 ALA A HB3  1 
ATOM   1607 N N    . ASN A 1 103 ? 23.08515  2.71409   5.37504   1.000 20.98643  ?  184 ASN A N    1 
ATOM   1608 C CA   A ASN A 1 103 ? 22.24291  2.15123   6.43392   0.570 20.33656  ?  184 ASN A CA   1 
ATOM   1609 C CA   B ASN A 1 103 ? 22.25267  2.15322   6.43343   0.430 20.42640  ?  184 ASN A CA   1 
ATOM   1610 C C    . ASN A 1 103 ? 22.37736  0.63285   6.39780   1.000 16.82423  ?  184 ASN A C    1 
ATOM   1611 O O    . ASN A 1 103 ? 21.43604  -0.07212  6.04529   1.000 21.17042  ?  184 ASN A O    1 
ATOM   1612 C CB   A ASN A 1 103 ? 20.74028  2.59576   6.33188   0.570 23.70883  ?  184 ASN A CB   1 
ATOM   1613 C CB   B ASN A 1 103 ? 20.79708  2.60010   6.31290   0.430 23.79402  ?  184 ASN A CB   1 
ATOM   1614 C CG   A ASN A 1 103 ? 19.82915  1.94478   7.41956   0.570 29.83339  ?  184 ASN A CG   1 
ATOM   1615 C CG   B ASN A 1 103 ? 20.55860  3.98789   6.88443   0.430 34.10577  ?  184 ASN A CG   1 
ATOM   1616 O OD1  A ASN A 1 103 ? 20.27666  1.13092   8.23809   0.570 24.29908  ?  184 ASN A OD1  1 
ATOM   1617 O OD1  B ASN A 1 103 ? 21.28626  4.45170   7.76599   0.430 30.08479  ?  184 ASN A OD1  1 
ATOM   1618 N ND2  A ASN A 1 103 ? 18.53915  2.31715   7.41990   0.570 31.60289  ?  184 ASN A ND2  1 
ATOM   1619 N ND2  B ASN A 1 103 ? 19.52356  4.65503   6.38835   0.430 42.24196  ?  184 ASN A ND2  1 
ATOM   1620 H H    A ASN A 1 103 ? 22.78440  2.44906   4.43711   0.040 25.18371  ?  184 ASN A H    1 
ATOM   1621 D D    B ASN A 1 103 ? 22.78353  2.45195   4.43658   0.960 25.18371  ?  184 ASN A D    1 
ATOM   1622 H HA   A ASN A 1 103 ? 22.61689  2.52950   7.38532   0.570 24.40387  ?  184 ASN A HA   1 
ATOM   1623 H HA   B ASN A 1 103 ? 22.62868  2.51488   7.39046   0.430 24.51168  ?  184 ASN A HA   1 
ATOM   1624 H HB2  A ASN A 1 103 ? 20.68337  3.67768   6.45155   0.570 28.45060  ?  184 ASN A HB2  1 
ATOM   1625 H HB2  B ASN A 1 103 ? 20.51671  2.61666   5.25970   0.430 28.55283  ?  184 ASN A HB2  1 
ATOM   1626 H HB3  A ASN A 1 103 ? 20.35262  2.30788   5.35467   0.570 28.45060  ?  184 ASN A HB3  1 
ATOM   1627 H HB3  B ASN A 1 103 ? 20.16404  1.89856   6.85622   0.430 28.55283  ?  184 ASN A HB3  1 
ATOM   1628 H HD21 A ASN A 1 103 ? 17.89542  1.92535   8.10730   0.570 37.92347  ?  184 ASN A HD21 1 
ATOM   1629 H HD21 B ASN A 1 103 ? 19.30965  5.59202   6.72994   0.430 50.69035  ?  184 ASN A HD21 1 
ATOM   1630 H HD22 A ASN A 1 103 ? 18.20289  2.99181   6.73277   0.570 37.92347  ?  184 ASN A HD22 1 
ATOM   1631 H HD22 B ASN A 1 103 ? 18.94224  4.23060   5.66563   0.430 50.69035  ?  184 ASN A HD22 1 
ATOM   1632 N N    . ASN A 1 104 ? 23.56836  0.13550   6.73734   1.000 21.29702  ?  185 ASN A N    1 
ATOM   1633 C CA   . ASN A 1 104 ? 23.81037  -1.30690  6.88447   1.000 23.82454  ?  185 ASN A CA   1 
ATOM   1634 C C    . ASN A 1 104 ? 23.46934  -2.08303  5.61754   1.000 18.63508  ?  185 ASN A C    1 
ATOM   1635 O O    . ASN A 1 104 ? 22.99259  -3.21701  5.70822   1.000 19.83937  ?  185 ASN A O    1 
ATOM   1636 C CB   . ASN A 1 104 ? 22.96568  -1.92902  8.00901   1.000 28.30323  ?  185 ASN A CB   1 
ATOM   1637 C CG   . ASN A 1 104 ? 23.33216  -1.43657  9.36224   1.000 57.63652  ?  185 ASN A CG   1 
ATOM   1638 O OD1  . ASN A 1 104 ? 24.45333  -1.65926  9.81364   1.000 51.99375  ?  185 ASN A OD1  1 
ATOM   1639 N ND2  . ASN A 1 104 ? 22.36614  -0.76620  10.05001  1.000 39.31516  ?  185 ASN A ND2  1 
ATOM   1640 H H    A ASN A 1 104 ? 24.39289  0.70783   6.91901   0.000 25.55642  ?  185 ASN A H    1 
ATOM   1641 D D    B ASN A 1 104 ? 24.39219  0.70891   6.91877   1.000 25.55642  ?  185 ASN A D    1 
ATOM   1642 H HA   . ASN A 1 104 ? 24.87210  -1.40317  7.11156   1.000 28.58944  ?  185 ASN A HA   1 
ATOM   1643 H HB2  . ASN A 1 104 ? 21.91692  -1.68635  7.83775   1.000 33.96388  ?  185 ASN A HB2  1 
ATOM   1644 H HB3  . ASN A 1 104 ? 23.10484  -3.01004  7.99775   1.000 33.96388  ?  185 ASN A HB3  1 
ATOM   1645 N N    . GLY A 1 105 ? 23.70104  -1.47508  4.44820   1.000 17.06651  ?  186 GLY A N    1 
ATOM   1646 C CA   . GLY A 1 105 ? 23.17834  -2.05165  3.21568   1.000 17.98902  ?  186 GLY A CA   1 
ATOM   1647 C C    . GLY A 1 105 ? 23.71259  -3.43433  2.92608   1.000 14.10949  ?  186 GLY A C    1 
ATOM   1648 O O    . GLY A 1 105 ? 22.95098  -4.34031  2.58557   1.000 14.91394  ?  186 GLY A O    1 
ATOM   1649 H H    A GLY A 1 105 ? 24.22989  -0.61109  4.32887   0.000 20.47981  ?  186 GLY A H    1 
ATOM   1650 D D    B GLY A 1 105 ? 24.22939  -0.61123  4.32568   1.000 20.47981  ?  186 GLY A D    1 
ATOM   1651 H HA2  . GLY A 1 105 ? 22.09244  -2.11589  3.28501   1.000 21.58682  ?  186 GLY A HA2  1 
ATOM   1652 H HA3  . GLY A 1 105 ? 23.44287  -1.40443  2.37948   1.000 21.58682  ?  186 GLY A HA3  1 
ATOM   1653 N N    . GLN A 1 106 ? 25.01746  -3.62329  3.08866   1.000 14.45648  ?  187 GLN A N    1 
ATOM   1654 C CA   . GLN A 1 106 ? 25.60412  -4.92851  2.79737   1.000 15.18185  ?  187 GLN A CA   1 
ATOM   1655 C C    . GLN A 1 106 ? 25.06544  -5.98514  3.72180   1.000 12.66855  ?  187 GLN A C    1 
ATOM   1656 O O    . GLN A 1 106 ? 24.71597  -7.08098  3.28323   1.000 14.64826  ?  187 GLN A O    1 
ATOM   1657 C CB   . GLN A 1 106 ? 27.12180  -4.84440  2.89779   1.000 17.38118  ?  187 GLN A CB   1 
ATOM   1658 C CG   . GLN A 1 106 ? 27.77005  -6.15004  2.51068   1.000 17.27053  ?  187 GLN A CG   1 
ATOM   1659 C CD   . GLN A 1 106 ? 29.25640  -6.06282  2.42939   1.000 19.18893  ?  187 GLN A CD   1 
ATOM   1660 O OE1  . GLN A 1 106 ? 29.79613  -5.04801  1.99655   1.000 19.18057  ?  187 GLN A OE1  1 
ATOM   1661 N NE2  . GLN A 1 106 ? 29.94523  -7.13023  2.87341   1.000 19.40537  ?  187 GLN A NE2  1 
ATOM   1662 H H    A GLN A 1 106 ? 25.67821  -2.91613  3.41074   0.010 17.34777  ?  187 GLN A H    1 
ATOM   1663 D D    B GLN A 1 106 ? 25.68018  -2.91789  3.41054   0.990 17.34777  ?  187 GLN A D    1 
ATOM   1664 H HA   . GLN A 1 106 ? 25.34764  -5.21589  1.77770   1.000 18.21822  ?  187 GLN A HA   1 
ATOM   1665 H HB2  . GLN A 1 106 ? 27.48543  -4.06686  2.22599   1.000 20.85741  ?  187 GLN A HB2  1 
ATOM   1666 H HB3  . GLN A 1 106 ? 27.40320  -4.61134  3.92473   1.000 20.85741  ?  187 GLN A HB3  1 
ATOM   1667 H HG2  . GLN A 1 106 ? 27.51845  -6.90468  3.25588   1.000 20.72464  ?  187 GLN A HG2  1 
ATOM   1668 H HG3  . GLN A 1 106 ? 27.39770  -6.45360  1.53226   1.000 20.72464  ?  187 GLN A HG3  1 
ATOM   1669 N N    . ALA A 1 107 ? 24.98674  -5.68696  5.02985   1.000 14.23109  ?  188 ALA A N    1 
ATOM   1670 C CA   . ALA A 1 107 ? 24.45865  -6.67113  5.97097   1.000 15.41286  ?  188 ALA A CA   1 
ATOM   1671 C C    . ALA A 1 107 ? 23.00670  -7.00692  5.65495   1.000 13.93863  ?  188 ALA A C    1 
ATOM   1672 O O    . ALA A 1 107 ? 22.60038  -8.17440  5.74032   1.000 15.18937  ?  188 ALA A O    1 
ATOM   1673 C CB   . ALA A 1 107 ? 24.58757  -6.15131  7.41288   1.000 17.29068  ?  188 ALA A CB   1 
ATOM   1674 H H    A ALA A 1 107 ? 25.27217  -4.80175  5.44859   0.090 17.07731  ?  188 ALA A H    1 
ATOM   1675 D D    B ALA A 1 107 ? 25.27145  -4.80266  5.45098   0.910 17.07731  ?  188 ALA A D    1 
ATOM   1676 H HA   . ALA A 1 107 ? 25.04727  -7.58486  5.88898   1.000 18.49543  ?  188 ALA A HA   1 
ATOM   1677 H HB1  . ALA A 1 107 ? 24.55659  -6.99749  8.09927   1.000 20.74881  ?  188 ALA A HB1  1 
ATOM   1678 H HB2  . ALA A 1 107 ? 25.53552  -5.62330  7.51633   1.000 20.74881  ?  188 ALA A HB2  1 
ATOM   1679 H HB3  . ALA A 1 107 ? 23.75984  -5.47335  7.62104   1.000 20.74881  ?  188 ALA A HB3  1 
ATOM   1680 N N    . ASN A 1 108 ? 22.21514  -6.00078  5.26014   1.000 14.35995  ?  189 ASN A N    1 
ATOM   1681 C CA   . ASN A 1 108 ? 20.82815  -6.27863  4.91277   1.000 15.10526  ?  189 ASN A CA   1 
ATOM   1682 C C    . ASN A 1 108 ? 20.74228  -7.15859  3.66515   1.000 13.64035  ?  189 ASN A C    1 
ATOM   1683 O O    . ASN A 1 108 ? 19.87861  -8.03802  3.55756   1.000 13.49722  ?  189 ASN A O    1 
ATOM   1684 C CB   . ASN A 1 108 ? 20.06960  -4.97253  4.69621   1.000 15.55950  ?  189 ASN A CB   1 
ATOM   1685 C CG   . ASN A 1 108 ? 19.84633  -4.18484  6.00006   1.000 20.87508  ?  189 ASN A CG   1 
ATOM   1686 O OD1  . ASN A 1 108 ? 19.74100  -4.77990  7.05134   1.000 24.73868  ?  189 ASN A OD1  1 
ATOM   1687 N ND2  . ASN A 1 108 ? 19.78087  -2.85786  5.90544   1.000 22.02277  ?  189 ASN A ND2  1 
ATOM   1688 H H    A ASN A 1 108 ? 22.49828  -5.02450  5.17586   0.000 17.23194  ?  189 ASN A H    1 
ATOM   1689 D D    B ASN A 1 108 ? 22.49588  -5.02387  5.17507   1.000 17.23194  ?  189 ASN A D    1 
ATOM   1690 H HA   . ASN A 1 108 ? 20.35667  -6.80891  5.74018   1.000 18.12631  ?  189 ASN A HA   1 
ATOM   1691 H HB2  . ASN A 1 108 ? 20.63941  -4.34052  4.01504   1.000 18.67140  ?  189 ASN A HB2  1 
ATOM   1692 H HB3  . ASN A 1 108 ? 19.09285  -5.19686  4.26756   1.000 18.67140  ?  189 ASN A HB3  1 
ATOM   1693 N N    . TYR A 1 109 ? 21.62914  -6.90013  2.69393   1.000 13.03981  ?  190 TYR A N    1 
ATOM   1694 C CA   . TYR A 1 109 ? 21.63311  -7.70346  1.47259   1.000 12.57498  ?  190 TYR A CA   1 
ATOM   1695 C C    . TYR A 1 109 ? 21.99807  -9.14789  1.77051   1.000 12.07009  ?  190 TYR A C    1 
ATOM   1696 O O    . TYR A 1 109 ? 21.39469  -10.09592 1.25209   1.000 12.58714  ?  190 TYR A O    1 
ATOM   1697 C CB   . TYR A 1 109 ? 22.58776  -7.08971  0.46146   1.000 12.38290  ?  190 TYR A CB   1 
ATOM   1698 C CG   . TYR A 1 109 ? 22.52865  -7.78231  -0.86300  1.000 11.30507  ?  190 TYR A CG   1 
ATOM   1699 C CD1  . TYR A 1 109 ? 21.56328  -7.43113  -1.78027  1.000 11.42806  ?  190 TYR A CD1  1 
ATOM   1700 C CD2  . TYR A 1 109 ? 23.40717  -8.80452  -1.19257  1.000 11.85367  ?  190 TYR A CD2  1 
ATOM   1701 C CE1  . TYR A 1 109 ? 21.48512  -8.06486  -3.00972  1.000 12.37635  ?  190 TYR A CE1  1 
ATOM   1702 C CE2  . TYR A 1 109 ? 23.34037  -9.44443  -2.45145  1.000 12.17663  ?  190 TYR A CE2  1 
ATOM   1703 C CZ   . TYR A 1 109 ? 22.37799  -9.05389  -3.30189  1.000 11.23045  ?  190 TYR A CZ   1 
ATOM   1704 O OH   . TYR A 1 109 ? 22.30963  -9.68200  -4.52748  1.000 12.80396  ?  190 TYR A OH   1 
ATOM   1705 H H    A TYR A 1 109 ? 22.33433  -6.16381  2.72462   0.700 15.64777  ?  190 TYR A H    1 
ATOM   1706 D D    B TYR A 1 109 ? 22.33518  -6.16453  2.72222   0.300 15.64777  ?  190 TYR A D    1 
ATOM   1707 H HA   . TYR A 1 109 ? 20.63590  -7.70119  1.03251   1.000 15.08997  ?  190 TYR A HA   1 
ATOM   1708 H HB2  . TYR A 1 109 ? 22.32367  -6.04305  0.31025   1.000 14.85948  ?  190 TYR A HB2  1 
ATOM   1709 H HB3  . TYR A 1 109 ? 23.60698  -7.16605  0.84023   1.000 14.85948  ?  190 TYR A HB3  1 
ATOM   1710 H HD1  . TYR A 1 109 ? 20.85722  -6.65070  -1.53774  1.000 13.71367  ?  190 TYR A HD1  1 
ATOM   1711 H HD2  . TYR A 1 109 ? 24.15330  -9.11602  -0.47657  1.000 14.22440  ?  190 TYR A HD2  1 
ATOM   1712 H HE1  . TYR A 1 109 ? 20.72868  -7.78014  -3.72605  1.000 14.85162  ?  190 TYR A HE1  1 
ATOM   1713 H HE2  . TYR A 1 109 ? 24.04042  -10.22173 -2.72001  1.000 14.61195  ?  190 TYR A HE2  1 
ATOM   1714 H HH   A TYR A 1 109 ? 21.79201  -9.13606  -5.15550  0.000 15.36475  ?  190 TYR A HH   1 
ATOM   1715 D DH   B TYR A 1 109 ? 21.71132  -9.18669  -5.12505  1.000 15.36475  ?  190 TYR A DH   1 
ATOM   1716 N N    . GLU A 1 110 ? 22.99622  -9.34983  2.63894   1.000 12.94972  ?  191 GLU A N    1 
ATOM   1717 C CA   . GLU A 1 110 ? 23.37991  -10.70968 2.98581   1.000 14.36823  ?  191 GLU A CA   1 
ATOM   1718 C C    . GLU A 1 110 ? 22.24481  -11.45881 3.67849   1.000 12.07601  ?  191 GLU A C    1 
ATOM   1719 O O    . GLU A 1 110 ? 22.02020  -12.62746 3.41532   1.000 13.29599  ?  191 GLU A O    1 
ATOM   1720 C CB   . GLU A 1 110 ? 24.66689  -10.69217 3.81220   1.000 16.18412  ?  191 GLU A CB   1 
ATOM   1721 C CG   . GLU A 1 110 ? 25.84546  -10.18996 2.95339   1.000 19.15168  ?  191 GLU A CG   1 
ATOM   1722 C CD   . GLU A 1 110 ? 27.18500  -10.03132 3.71091   1.000 32.13385  ?  191 GLU A CD   1 
ATOM   1723 O OE1  . GLU A 1 110 ? 27.20739  -10.32239 4.91897   1.000 33.85467  ?  191 GLU A OE1  1 
ATOM   1724 O OE2  . GLU A 1 110 ? 28.18508  -9.58741  3.09194   1.000 38.71830  -1 191 GLU A OE2  1 
ATOM   1725 H H    A GLU A 1 110 ? 23.53500  -8.61612  3.09912   1.000 15.53967  ?  191 GLU A H    1 
ATOM   1726 D D    B GLU A 1 110 ? 23.53642  -8.61795  3.10038   0.000 15.53967  ?  191 GLU A D    1 
ATOM   1727 H HA   . GLU A 1 110 ? 23.59747  -11.26736 2.07489   1.000 17.24187  ?  191 GLU A HA   1 
ATOM   1728 H HB2  . GLU A 1 110 ? 24.54526  -10.02314 4.66408   1.000 19.42094  ?  191 GLU A HB2  1 
ATOM   1729 H HB3  . GLU A 1 110 ? 24.89221  -11.70056 4.15930   1.000 19.42094  ?  191 GLU A HB3  1 
ATOM   1730 H HG2  . GLU A 1 110 ? 26.01060  -10.90085 2.14378   1.000 22.98202  ?  191 GLU A HG2  1 
ATOM   1731 H HG3  . GLU A 1 110 ? 25.58400  -9.21382  2.54486   1.000 22.98202  ?  191 GLU A HG3  1 
ATOM   1732 N N    . ASN A 1 111 ? 21.46777  -10.76211 4.50986   1.000 13.68905  ?  192 ASN A N    1 
ATOM   1733 C CA   . ASN A 1 111 ? 20.29526  -11.37973 5.10486   1.000 12.49234  ?  192 ASN A CA   1 
ATOM   1734 C C    . ASN A 1 111 ? 19.22891  -11.73061 4.06040   1.000 12.90488  ?  192 ASN A C    1 
ATOM   1735 O O    . ASN A 1 111 ? 18.61078  -12.80205 4.11550   1.000 14.50973  ?  192 ASN A O    1 
ATOM   1736 C CB   . ASN A 1 111 ? 19.73425  -10.44382 6.18661   1.000 16.63979  ?  192 ASN A CB   1 
ATOM   1737 C CG   . ASN A 1 111 ? 18.50267  -11.00585 6.83566   1.000 27.59525  ?  192 ASN A CG   1 
ATOM   1738 O OD1  . ASN A 1 111 ? 17.39508  -10.47884 6.65814   1.000 31.43029  ?  192 ASN A OD1  1 
ATOM   1739 N ND2  . ASN A 1 111 ? 18.66982  -12.13588 7.52813   1.000 27.79922  ?  192 ASN A ND2  1 
ATOM   1740 H H    A ASN A 1 111 ? 21.62358  -9.79148  4.78189   0.910 16.42686  ?  192 ASN A H    1 
ATOM   1741 D D    B ASN A 1 111 ? 21.62140  -9.79156  4.78342   0.090 16.42686  ?  192 ASN A D    1 
ATOM   1742 H HA   . ASN A 1 111 ? 20.58532  -12.32013 5.57349   1.000 14.99081  ?  192 ASN A HA   1 
ATOM   1743 H HB2  . ASN A 1 111 ? 20.48893  -10.29643 6.95916   1.000 19.96775  ?  192 ASN A HB2  1 
ATOM   1744 H HB3  . ASN A 1 111 ? 19.47357  -9.48766  5.73285   1.000 19.96775  ?  192 ASN A HB3  1 
ATOM   1745 N N    . TYR A 1 112 ? 19.02008  -10.83250 3.08819   1.000 12.62635  ?  193 TYR A N    1 
ATOM   1746 C CA   . TYR A 1 112 ? 18.14801  -11.12604 1.93700   1.000 12.56222  ?  193 TYR A CA   1 
ATOM   1747 C C    . TYR A 1 112 ? 18.56441  -12.41991 1.20920   1.000 11.64490  ?  193 TYR A C    1 
ATOM   1748 O O    . TYR A 1 112 ? 17.74505  -13.30821 0.97435   1.000 12.73364  ?  193 TYR A O    1 
ATOM   1749 C CB   . TYR A 1 112 ? 18.12557  -9.90159  1.03711   1.000 13.30610  ?  193 TYR A CB   1 
ATOM   1750 C CG   . TYR A 1 112 ? 17.72722  -10.04142 -0.41956  1.000 12.54040  ?  193 TYR A CG   1 
ATOM   1751 C CD1  . TYR A 1 112 ? 16.39342  -9.96203  -0.82972  1.000 13.60328  ?  193 TYR A CD1  1 
ATOM   1752 C CD2  . TYR A 1 112 ? 18.71241  -10.18598 -1.38836  1.000 12.69766  ?  193 TYR A CD2  1 
ATOM   1753 C CE1  . TYR A 1 112 ? 16.05830  -10.02913 -2.17691  1.000 12.25239  ?  193 TYR A CE1  1 
ATOM   1754 C CE2  . TYR A 1 112 ? 18.39172  -10.23768 -2.71593  1.000 13.32778  ?  193 TYR A CE2  1 
ATOM   1755 C CZ   . TYR A 1 112 ? 17.06568  -10.17778 -3.09998  1.000 12.39715  ?  193 TYR A CZ   1 
ATOM   1756 O OH   . TYR A 1 112 ? 16.79927  -10.25783 -4.44481  1.000 13.62688  ?  193 TYR A OH   1 
ATOM   1757 H H    A TYR A 1 112 ? 19.43441  -9.90073  3.06527   0.950 15.15163  ?  193 TYR A H    1 
ATOM   1758 D D    B TYR A 1 112 ? 19.43337  -9.90032  3.06334   0.050 15.15163  ?  193 TYR A D    1 
ATOM   1759 H HA   . TYR A 1 112 ? 17.12622  -11.31218 2.26775   1.000 15.07466  ?  193 TYR A HA   1 
ATOM   1760 H HB2  . TYR A 1 112 ? 17.42516  -9.19078  1.47562   1.000 15.96732  ?  193 TYR A HB2  1 
ATOM   1761 H HB3  . TYR A 1 112 ? 19.13153  -9.48191  1.03693   1.000 15.96732  ?  193 TYR A HB3  1 
ATOM   1762 H HD1  . TYR A 1 112 ? 15.61395  -9.84720  -0.09104  1.000 16.32394  ?  193 TYR A HD1  1 
ATOM   1763 H HD2  . TYR A 1 112 ? 19.74724  -10.25860 -1.08792  1.000 15.23719  ?  193 TYR A HD2  1 
ATOM   1764 H HE1  . TYR A 1 112 ? 15.02723  -9.96574  -2.49201  1.000 14.70287  ?  193 TYR A HE1  1 
ATOM   1765 H HE2  . TYR A 1 112 ? 19.16966  -10.32478 -3.45999  1.000 15.99333  ?  193 TYR A HE2  1 
ATOM   1766 H HH   A TYR A 1 112 ? 15.88156  -9.96366  -4.62280  0.030 16.35226  ?  193 TYR A HH   1 
ATOM   1767 D DH   B TYR A 1 112 ? 15.87841  -9.97294  -4.62163  0.970 16.35226  ?  193 TYR A DH   1 
ATOM   1768 N N    . ILE A 1 113 ? 19.86622  -12.57797 0.92984   1.000 11.79848  ?  194 ILE A N    1 
ATOM   1769 C CA   . ILE A 1 113 ? 20.35982  -13.80065 0.29794   1.000 12.39244  ?  194 ILE A CA   1 
ATOM   1770 C C    . ILE A 1 113 ? 20.13778  -15.01261 1.20547   1.000 12.36457  ?  194 ILE A C    1 
ATOM   1771 O O    . ILE A 1 113 ? 19.69548  -16.07501 0.75588   1.000 13.03650  ?  194 ILE A O    1 
ATOM   1772 C CB   . ILE A 1 113 ? 21.84177  -13.63764 -0.11091  1.000 11.47331  ?  194 ILE A CB   1 
ATOM   1773 C CG1  . ILE A 1 113 ? 22.02397  -12.58215 -1.20473  1.000 11.76559  ?  194 ILE A CG1  1 
ATOM   1774 C CG2  . ILE A 1 113 ? 22.41085  -14.96334 -0.54220  1.000 12.34840  ?  194 ILE A CG2  1 
ATOM   1775 C CD1  . ILE A 1 113 ? 21.32737  -12.89285 -2.54880  1.000 12.73892  ?  194 ILE A CD1  1 
ATOM   1776 H H    A ILE A 1 113 ? 20.59009  -11.88689 1.12686   0.960 14.15818  ?  194 ILE A H    1 
ATOM   1777 D D    B ILE A 1 113 ? 20.59177  -11.88839 1.12592   0.040 14.15818  ?  194 ILE A D    1 
ATOM   1778 H HA   . ILE A 1 113 ? 19.78542  -13.97091 -0.61266  1.000 14.87093  ?  194 ILE A HA   1 
ATOM   1779 H HB   . ILE A 1 113 ? 22.38664  -13.28474 0.76470   1.000 13.76797  ?  194 ILE A HB   1 
ATOM   1780 H HG12 . ILE A 1 113 ? 21.62039  -11.63734 -0.84064  1.000 14.11871  ?  194 ILE A HG12 1 
ATOM   1781 H HG13 . ILE A 1 113 ? 23.08988  -12.47870 -1.40774  1.000 14.11871  ?  194 ILE A HG13 1 
ATOM   1782 H HG21 . ILE A 1 113 ? 23.41293  -14.80640 -0.94133  1.000 14.81808  ?  194 ILE A HG21 1 
ATOM   1783 H HG22 . ILE A 1 113 ? 22.45424  -15.62839 0.32031   1.000 14.81808  ?  194 ILE A HG22 1 
ATOM   1784 H HG23 . ILE A 1 113 ? 21.76773  -15.39253 -1.31051  1.000 14.81808  ?  194 ILE A HG23 1 
ATOM   1785 H HD11 . ILE A 1 113 ? 21.49847  -12.06498 -3.23688  1.000 15.28671  ?  194 ILE A HD11 1 
ATOM   1786 H HD12 . ILE A 1 113 ? 21.74523  -13.81128 -2.96109  1.000 15.28671  ?  194 ILE A HD12 1 
ATOM   1787 H HD13 . ILE A 1 113 ? 20.25853  -13.01633 -2.37433  1.000 15.28671  ?  194 ILE A HD13 1 
ATOM   1788 N N    . ASP A 1 114 ? 20.42070  -14.85725 2.50488   1.000 12.49448  ?  195 ASP A N    1 
ATOM   1789 C CA   . ASP A 1 114 ? 20.28009  -15.99658 3.41812   1.000 12.76029  ?  195 ASP A CA   1 
ATOM   1790 C C    . ASP A 1 114 ? 18.83128  -16.48028 3.46085   1.000 13.08960  ?  195 ASP A C    1 
ATOM   1791 O O    . ASP A 1 114 ? 18.56689  -17.68505 3.51844   1.000 14.55989  ?  195 ASP A O    1 
ATOM   1792 C CB   . ASP A 1 114 ? 20.71582  -15.62816 4.84153   1.000 13.78949  ?  195 ASP A CB   1 
ATOM   1793 C CG   . ASP A 1 114 ? 22.18890  -15.39851 4.98923   1.000 18.98414  ?  195 ASP A CG   1 
ATOM   1794 O OD1  . ASP A 1 114 ? 22.98866  -15.79056 4.11082   1.000 16.97091  ?  195 ASP A OD1  1 
ATOM   1795 O OD2  . ASP A 1 114 ? 22.53884  -14.80563 6.02648   1.000 21.09489  -1 195 ASP A OD2  1 
ATOM   1796 H H    A ASP A 1 114 ? 20.73690  -13.99032 2.93946   1.000 14.99338  ?  195 ASP A H    1 
ATOM   1797 D D    B ASP A 1 114 ? 20.73700  -13.99154 2.94180   0.000 14.99338  ?  195 ASP A D    1 
ATOM   1798 H HA   . ASP A 1 114 ? 20.93088  -16.79210 3.05519   1.000 15.31235  ?  195 ASP A HA   1 
ATOM   1799 H HB2  . ASP A 1 114 ? 20.20677  -14.71056 5.13646   1.000 16.54739  ?  195 ASP A HB2  1 
ATOM   1800 H HB3  . ASP A 1 114 ? 20.43871  -16.44063 5.51325   1.000 16.54739  ?  195 ASP A HB3  1 
ATOM   1801 N N    . GLN A 1 115 ? 17.88088  -15.55500 3.40061   1.000 13.94950  ?  196 GLN A N    1 
ATOM   1802 C CA   . GLN A 1 115 ? 16.47221  -15.92658 3.39834   1.000 13.48089  ?  196 GLN A CA   1 
ATOM   1803 C C    . GLN A 1 115 ? 16.07507  -16.64489 2.11484   1.000 15.52233  ?  196 GLN A C    1 
ATOM   1804 O O    . GLN A 1 115 ? 15.23162  -17.55584 2.13216   1.000 16.05438  ?  196 GLN A O    1 
ATOM   1805 C CB   . GLN A 1 115 ? 15.60130  -14.68750 3.58148   1.000 17.75746  ?  196 GLN A CB   1 
ATOM   1806 C CG   . GLN A 1 115 ? 15.67412  -14.06049 5.02379   1.000 19.34648  ?  196 GLN A CG   1 
ATOM   1807 C CD   . GLN A 1 115 ? 14.67912  -12.87773 5.18227   1.000 41.43997  ?  196 GLN A CD   1 
ATOM   1808 O OE1  . GLN A 1 115 ? 13.47950  -13.03667 4.93587   1.000 40.33793  ?  196 GLN A OE1  1 
ATOM   1809 N NE2  . GLN A 1 115 ? 15.18402  -11.69818 5.55112   1.000 32.12055  ?  196 GLN A NE2  1 
ATOM   1810 H H    A GLN A 1 115 ? 18.05003  -14.55026 3.35294   1.000 16.73940  ?  196 GLN A H    1 
ATOM   1811 D D    B GLN A 1 115 ? 18.04738  -14.54982 3.35288   0.000 16.73940  ?  196 GLN A D    1 
ATOM   1812 H HA   . GLN A 1 115 ? 16.30315  -16.60388 4.23547   1.000 16.17707  ?  196 GLN A HA   1 
ATOM   1813 H HB2  . GLN A 1 115 ? 15.92437  -13.92561 2.87208   1.000 21.30896  ?  196 GLN A HB2  1 
ATOM   1814 H HB3  . GLN A 1 115 ? 14.56315  -14.95892 3.39001   1.000 21.30896  ?  196 GLN A HB3  1 
ATOM   1815 H HG2  . GLN A 1 115 ? 15.42137  -14.82232 5.76124   1.000 23.21578  ?  196 GLN A HG2  1 
ATOM   1816 H HG3  . GLN A 1 115 ? 16.68215  -13.68704 5.20405   1.000 23.21578  ?  196 GLN A HG3  1 
ATOM   1817 N N    . ILE A 1 116 ? 16.62127  -16.20906 0.97124   1.000 13.83720  ?  197 ILE A N    1 
ATOM   1818 C CA   . ILE A 1 116 ? 16.38216  -16.90768 -0.29256  1.000 14.04312  ?  197 ILE A CA   1 
ATOM   1819 C C    . ILE A 1 116 ? 16.96199  -18.31950 -0.23079  1.000 12.47115  ?  197 ILE A C    1 
ATOM   1820 O O    . ILE A 1 116 ? 16.30722  -19.29444 -0.61278  1.000 13.78560  ?  197 ILE A O    1 
ATOM   1821 C CB   . ILE A 1 116 ? 16.96329  -16.09807 -1.47371  1.000 12.94199  ?  197 ILE A CB   1 
ATOM   1822 C CG1  . ILE A 1 116 ? 16.13209  -14.85375 -1.65707  1.000 13.41394  ?  197 ILE A CG1  1 
ATOM   1823 C CG2  . ILE A 1 116 ? 16.96285  -16.92859 -2.73859  1.000 14.69268  ?  197 ILE A CG2  1 
ATOM   1824 C CD1  . ILE A 1 116 ? 16.77614  -13.80200 -2.53667  1.000 17.18559  ?  197 ILE A CD1  1 
ATOM   1825 H H    A ILE A 1 116 ? 17.22306  -15.38947 0.89057   0.910 16.60465  ?  197 ILE A H    1 
ATOM   1826 D D    B ILE A 1 116 ? 17.22325  -15.38982 0.88845   0.090 16.60465  ?  197 ILE A D    1 
ATOM   1827 H HA   . ILE A 1 116 ? 15.30681  -16.99492 -0.44781  1.000 16.85174  ?  197 ILE A HA   1 
ATOM   1828 H HB   . ILE A 1 116 ? 17.99524  -15.82329 -1.25535  1.000 15.53039  ?  197 ILE A HB   1 
ATOM   1829 H HG12 . ILE A 1 116 ? 15.18334  -15.13259 -2.11555  1.000 16.09673  ?  197 ILE A HG12 1 
ATOM   1830 H HG13 . ILE A 1 116 ? 15.95607  -14.40480 -0.67954  1.000 16.09673  ?  197 ILE A HG13 1 
ATOM   1831 H HG21 . ILE A 1 116 ? 16.12952  -17.63025 -2.70211  1.000 17.63121  ?  197 ILE A HG21 1 
ATOM   1832 H HG22 . ILE A 1 116 ? 16.85408  -16.26664 -3.59771  1.000 17.63121  ?  197 ILE A HG22 1 
ATOM   1833 H HG23 . ILE A 1 116 ? 17.90465  -17.47320 -2.80585  1.000 17.63121  ?  197 ILE A HG23 1 
ATOM   1834 H HD11 . ILE A 1 116 ? 17.48305  -13.22509 -1.94039  1.000 20.62271  ?  197 ILE A HD11 1 
ATOM   1835 H HD12 . ILE A 1 116 ? 17.29764  -14.29591 -3.35654  1.000 20.62271  ?  197 ILE A HD12 1 
ATOM   1836 H HD13 . ILE A 1 116 ? 16.00035  -13.14584 -2.93125  1.000 20.62271  ?  197 ILE A HD13 1 
ATOM   1837 N N    . VAL A 1 117 ? 18.20146  -18.45088 0.24904   1.000 12.79424  ?  198 VAL A N    1 
ATOM   1838 C CA   . VAL A 1 117 ? 18.82776  -19.76714 0.37747   1.000 14.24323  ?  198 VAL A CA   1 
ATOM   1839 C C    . VAL A 1 117 ? 17.97317  -20.68367 1.25040   1.000 14.70312  ?  198 VAL A C    1 
ATOM   1840 O O    . VAL A 1 117 ? 17.78913  -21.87188 0.94343   1.000 15.88016  ?  198 VAL A O    1 
ATOM   1841 C CB   . VAL A 1 117 ? 20.27022  -19.61937 0.91890   1.000 15.47593  ?  198 VAL A CB   1 
ATOM   1842 C CG1  . VAL A 1 117 ? 20.83445  -20.98083 1.35165   1.000 20.24895  ?  198 VAL A CG1  1 
ATOM   1843 C CG2  . VAL A 1 117 ? 21.16715  -18.99074 -0.13351  1.000 17.58354  ?  198 VAL A CG2  1 
ATOM   1844 H H    A VAL A 1 117 ? 18.79062  -17.67591 0.55352   0.940 15.35309  ?  198 VAL A H    1 
ATOM   1845 D D    B VAL A 1 117 ? 18.79234  -17.67744 0.55406   0.060 15.35309  ?  198 VAL A D    1 
ATOM   1846 H HA   . VAL A 1 117 ? 18.89011  -20.22486 -0.60980  1.000 17.09188  ?  198 VAL A HA   1 
ATOM   1847 H HB   . VAL A 1 117 ? 20.24786  -18.96832 1.79282   1.000 18.57112  ?  198 VAL A HB   1 
ATOM   1848 H HG11 . VAL A 1 117 ? 21.13958  -20.92263 2.39645   1.000 24.29874  ?  198 VAL A HG11 1 
ATOM   1849 H HG12 . VAL A 1 117 ? 20.06121  -21.73969 1.23197   1.000 24.29874  ?  198 VAL A HG12 1 
ATOM   1850 H HG13 . VAL A 1 117 ? 21.69365  -21.22382 0.72648   1.000 24.29874  ?  198 VAL A HG13 1 
ATOM   1851 H HG21 . VAL A 1 117 ? 20.54831  -18.61264 -0.94726  1.000 21.10024  ?  198 VAL A HG21 1 
ATOM   1852 H HG22 . VAL A 1 117 ? 21.72609  -18.17203 0.31970   1.000 21.10024  ?  198 VAL A HG22 1 
ATOM   1853 H HG23 . VAL A 1 117 ? 21.85567  -19.74694 -0.51059  1.000 21.10024  ?  198 VAL A HG23 1 
ATOM   1854 N N    . ALA A 1 118 ? 17.43135  -20.14474 2.33962   1.000 14.77823  ?  199 ALA A N    1 
ATOM   1855 C CA   . ALA A 1 118 ? 16.65031  -20.96006 3.25589   1.000 16.76061  ?  199 ALA A CA   1 
ATOM   1856 C C    . ALA A 1 118 ? 15.40631  -21.52283 2.58252   1.000 17.37692  ?  199 ALA A C    1 
ATOM   1857 O O    . ALA A 1 118 ? 14.97970  -22.64462 2.89487   1.000 19.21922  ?  199 ALA A O    1 
ATOM   1858 C CB   . ALA A 1 118 ? 16.29907  -20.13339 4.49156   1.000 16.89600  ?  199 ALA A CB   1 
ATOM   1859 H H    A ALA A 1 118 ? 17.51432  -19.16453 2.60925   0.890 17.73388  ?  199 ALA A H    1 
ATOM   1860 D D    B ALA A 1 118 ? 17.51284  -19.16501 2.61143   0.110 17.73388  ?  199 ALA A D    1 
ATOM   1861 H HA   . ALA A 1 118 ? 17.24451  -21.81400 3.58117   1.000 20.11273  ?  199 ALA A HA   1 
ATOM   1862 H HB1  . ALA A 1 118 ? 16.07310  -20.80801 5.31735   1.000 20.27520  ?  199 ALA A HB1  1 
ATOM   1863 H HB2  . ALA A 1 118 ? 17.14925  -19.50190 4.74946   1.000 20.27520  ?  199 ALA A HB2  1 
ATOM   1864 H HB3  . ALA A 1 118 ? 15.43009  -19.51417 4.26900   1.000 20.27520  ?  199 ALA A HB3  1 
ATOM   1865 N N    . GLN A 1 119 ? 14.78362  -20.76229 1.68453   1.000 14.27881  ?  200 GLN A N    1 
ATOM   1866 C CA   . GLN A 1 119 ? 13.65727  -21.28308 0.93273   1.000 14.11923  ?  200 GLN A CA   1 
ATOM   1867 C C    . GLN A 1 119 ? 14.11096  -22.35287 -0.05105  1.000 15.83238  ?  200 GLN A C    1 
ATOM   1868 O O    . GLN A 1 119 ? 13.51168  -23.42956 -0.12925  1.000 17.74919  ?  200 GLN A O    1 
ATOM   1869 C CB   . GLN A 1 119 ? 12.93441  -20.16100 0.20540   1.000 16.04814  ?  200 GLN A CB   1 
ATOM   1870 C CG   . GLN A 1 119 ? 12.27789  -19.14921 1.12258   1.000 15.24554  ?  200 GLN A CG   1 
ATOM   1871 C CD   . GLN A 1 119 ? 11.05896  -19.70933 1.82653   1.000 19.64915  ?  200 GLN A CD   1 
ATOM   1872 O OE1  . GLN A 1 119 ? 10.59360  -20.78828 1.49129   1.000 20.69729  ?  200 GLN A OE1  1 
ATOM   1873 N NE2  . GLN A 1 119 ? 10.50505  -18.94820 2.78436   1.000 31.16108  ?  200 GLN A NE2  1 
ATOM   1874 H H    A GLN A 1 119 ? 15.03385  -19.79892 1.46155   0.970 17.13457  ?  200 GLN A H    1 
ATOM   1875 D D    B GLN A 1 119 ? 15.03209  -19.79884 1.45996   0.030 17.13457  ?  200 GLN A D    1 
ATOM   1876 H HA   . GLN A 1 119 ? 12.95165  -21.73203 1.63177   1.000 16.94308  ?  200 GLN A HA   1 
ATOM   1877 H HB2  . GLN A 1 119 ? 13.65432  -19.62705 -0.41486  1.000 19.25777  ?  200 GLN A HB2  1 
ATOM   1878 H HB3  . GLN A 1 119 ? 12.15444  -20.59620 -0.41937  1.000 19.25777  ?  200 GLN A HB3  1 
ATOM   1879 H HG2  . GLN A 1 119 ? 12.99499  -18.83960 1.88286   1.000 18.29465  ?  200 GLN A HG2  1 
ATOM   1880 H HG3  . GLN A 1 119 ? 11.96253  -18.28731 0.53455   1.000 18.29465  ?  200 GLN A HG3  1 
ATOM   1881 N N    . ILE A 1 120 ? 15.17427  -22.07702 -0.82737  1.000 14.21317  ?  201 ILE A N    1 
ATOM   1882 C CA   . ILE A 1 120 ? 15.59957  -23.01033 -1.87790  1.000 15.45559  ?  201 ILE A CA   1 
ATOM   1883 C C    . ILE A 1 120 ? 16.00454  -24.35955 -1.28528  1.000 15.82097  ?  201 ILE A C    1 
ATOM   1884 O O    . ILE A 1 120 ? 15.70447  -25.42779 -1.84963  1.000 16.91555  ?  201 ILE A O    1 
ATOM   1885 C CB   . ILE A 1 120 ? 16.72258  -22.35370 -2.70876  1.000 14.26448  ?  201 ILE A CB   1 
ATOM   1886 C CG1  . ILE A 1 120 ? 16.12595  -21.19807 -3.49855  1.000 15.04212  ?  201 ILE A CG1  1 
ATOM   1887 C CG2  . ILE A 1 120 ? 17.33077  -23.35307 -3.66721  1.000 16.82947  ?  201 ILE A CG2  1 
ATOM   1888 C CD1  . ILE A 1 120 ? 17.11652  -20.25806 -4.22902  1.000 18.59978  ?  201 ILE A CD1  1 
ATOM   1889 H H    A ILE A 1 120 ? 15.74622  -21.23569 -0.75362  1.000 17.05581  ?  201 ILE A H    1 
ATOM   1890 D D    B ILE A 1 120 ? 15.74757  -21.23646 -0.75539  0.000 17.05581  ?  201 ILE A D    1 
ATOM   1891 H HA   . ILE A 1 120 ? 14.76089  -23.21518 -2.54330  1.000 18.54671  ?  201 ILE A HA   1 
ATOM   1892 H HB   . ILE A 1 120 ? 17.50284  -21.99756 -2.03612  1.000 17.11737  ?  201 ILE A HB   1 
ATOM   1893 H HG12 . ILE A 1 120 ? 15.46656  -21.61601 -4.25923  1.000 18.05054  ?  201 ILE A HG12 1 
ATOM   1894 H HG13 . ILE A 1 120 ? 15.55314  -20.57934 -2.80777  1.000 18.05054  ?  201 ILE A HG13 1 
ATOM   1895 H HG21 . ILE A 1 120 ? 17.87400  -24.10652 -3.09685  1.000 20.19536  ?  201 ILE A HG21 1 
ATOM   1896 H HG22 . ILE A 1 120 ? 16.53329  -23.82487 -4.24126  1.000 20.19536  ?  201 ILE A HG22 1 
ATOM   1897 H HG23 . ILE A 1 120 ? 18.01314  -22.83131 -4.33821  1.000 20.19536  ?  201 ILE A HG23 1 
ATOM   1898 H HD11 . ILE A 1 120 ? 16.56904  -19.40068 -4.62051  1.000 22.31974  ?  201 ILE A HD11 1 
ATOM   1899 H HD12 . ILE A 1 120 ? 17.87517  -19.92315 -3.52163  1.000 22.31974  ?  201 ILE A HD12 1 
ATOM   1900 H HD13 . ILE A 1 120 ? 17.58632  -20.80415 -5.04706  1.000 22.31974  ?  201 ILE A HD13 1 
ATOM   1901 N N    . GLN A 1 121 ? 16.66438  -24.33591 -0.12961  1.000 16.33412  ?  202 GLN A N    1 
ATOM   1902 C CA   . GLN A 1 121 ? 17.14483  -25.56145 0.51162   1.000 17.16604  ?  202 GLN A CA   1 
ATOM   1903 C C    . GLN A 1 121 ? 16.01994  -26.53336 0.81049   1.000 18.63035  ?  202 GLN A C    1 
ATOM   1904 O O    . GLN A 1 121 ? 16.26442  -27.73916 0.92098   1.000 22.39170  ?  202 GLN A O    1 
ATOM   1905 C CB   . GLN A 1 121 ? 17.75693  -25.16071 1.85523   1.000 21.99878  ?  202 GLN A CB   1 
ATOM   1906 C CG   . GLN A 1 121 ? 19.06074  -25.70959 2.24372   1.000 42.26673  ?  202 GLN A CG   1 
ATOM   1907 C CD   . GLN A 1 121 ? 19.66191  -24.87433 3.37225   1.000 48.88338  ?  202 GLN A CD   1 
ATOM   1908 O OE1  . GLN A 1 121 ? 18.93766  -24.33889 4.22175   1.000 40.27164  ?  202 GLN A OE1  1 
ATOM   1909 N NE2  . GLN A 1 121 ? 20.98730  -24.72663 3.35944   1.000 44.67207  ?  202 GLN A NE2  1 
ATOM   1910 H H    A GLN A 1 121 ? 16.88418  -23.48670 0.39091   0.610 19.60095  ?  202 GLN A H    1 
ATOM   1911 D D    B GLN A 1 121 ? 16.88543  -23.48822 0.39285   0.390 19.60095  ?  202 GLN A D    1 
ATOM   1912 H HA   . GLN A 1 121 ? 17.86569  -26.04765 -0.14571  1.000 20.59925  ?  202 GLN A HA   1 
ATOM   1913 H HB2  . GLN A 1 121 ? 17.87084  -24.07668 1.85090   1.000 26.39854  ?  202 GLN A HB2  1 
ATOM   1914 H HB3  . GLN A 1 121 ? 17.05552  -25.45874 2.63453   1.000 26.39854  ?  202 GLN A HB3  1 
ATOM   1915 H HG2  . GLN A 1 121 ? 18.93830  -26.73468 2.59344   1.000 50.72007  ?  202 GLN A HG2  1 
ATOM   1916 H HG3  . GLN A 1 121 ? 19.73855  -25.68525 1.39044   1.000 50.72007  ?  202 GLN A HG3  1 
ATOM   1917 N N    . GLN A 1 122 ? 14.80125  -26.03600 0.99089   1.000 17.38252  ?  203 GLN A N    1 
ATOM   1918 C CA   . GLN A 1 122 ? 13.67522  -26.87446 1.39946   1.000 18.03415  ?  203 GLN A CA   1 
ATOM   1919 C C    . GLN A 1 122 ? 13.08926  -27.67498 0.24866   1.000 20.39144  ?  203 GLN A C    1 
ATOM   1920 O O    . GLN A 1 122 ? 12.28267  -28.58948 0.47303   1.000 20.70086  ?  203 GLN A O    1 
ATOM   1921 C CB   . GLN A 1 122 ? 12.58359  -25.98574 1.98234   1.000 18.70111  ?  203 GLN A CB   1 
ATOM   1922 C CG   . GLN A 1 122 ? 12.97612  -25.36979 3.32801   1.000 26.19387  ?  203 GLN A CG   1 
ATOM   1923 C CD   . GLN A 1 122 ? 11.92735  -24.38807 3.87260   1.000 34.05756  ?  203 GLN A CD   1 
ATOM   1924 O OE1  . GLN A 1 122 ? 10.76086  -24.75246 4.04280   1.000 43.13276  ?  203 GLN A OE1  1 
ATOM   1925 N NE2  . GLN A 1 122 ? 12.34057  -23.13523 4.13049   1.000 26.15715  ?  203 GLN A NE2  1 
ATOM   1926 H H    A GLN A 1 122 ? 14.55805  -25.05379 0.86236   0.110 20.85902  ?  203 GLN A H    1 
ATOM   1927 D D    B GLN A 1 122 ? 14.55783  -25.05384 0.86242   0.890 20.85902  ?  203 GLN A D    1 
ATOM   1928 H HA   . GLN A 1 122 ? 14.01149  -27.57705 2.16195   1.000 21.64098  ?  203 GLN A HA   1 
ATOM   1929 H HB2  . GLN A 1 122 ? 12.37883  -25.17260 1.28594   1.000 22.44133  ?  203 GLN A HB2  1 
ATOM   1930 H HB3  . GLN A 1 122 ? 11.68396  -26.58225 2.13386   1.000 22.44133  ?  203 GLN A HB3  1 
ATOM   1931 H HG2  . GLN A 1 122 ? 13.09934  -26.16830 4.05965   1.000 31.43264  ?  203 GLN A HG2  1 
ATOM   1932 H HG3  . GLN A 1 122 ? 13.91329  -24.82629 3.20794   1.000 31.43264  ?  203 GLN A HG3  1 
ATOM   1933 N N    . PHE A 1 123 ? 13.43516  -27.34642 -0.99083  1.000 18.18597  ?  204 PHE A N    1 
ATOM   1934 C CA   . PHE A 1 123 ? 12.87137  -28.01272 -2.16194  1.000 19.20281  ?  204 PHE A CA   1 
ATOM   1935 C C    . PHE A 1 123 ? 13.96777  -28.41847 -3.12719  1.000 19.17190  ?  204 PHE A C    1 
ATOM   1936 O O    . PHE A 1 123 ? 14.04004  -27.91122 -4.25794  1.000 18.63651  ?  204 PHE A O    1 
ATOM   1937 C CB   . PHE A 1 123 ? 11.83143  -27.12197 -2.83927  1.000 19.39556  ?  204 PHE A CB   1 
ATOM   1938 C CG   . PHE A 1 123 ? 10.70041  -26.80655 -1.93992  1.000 24.00284  ?  204 PHE A CG   1 
ATOM   1939 C CD1  . PHE A 1 123 ? 9.70306   -27.73674 -1.75736  1.000 29.67074  ?  204 PHE A CD1  1 
ATOM   1940 C CD2  . PHE A 1 123 ? 10.66974  -25.63123 -1.23030  1.000 27.46191  ?  204 PHE A CD2  1 
ATOM   1941 C CE1  . PHE A 1 123 ? 8.66580   -27.48087 -0.89187  1.000 29.43494  ?  204 PHE A CE1  1 
ATOM   1942 C CE2  . PHE A 1 123 ? 9.63214   -25.37096 -0.36678  1.000 31.24347  ?  204 PHE A CE2  1 
ATOM   1943 C CZ   . PHE A 1 123 ? 8.64906   -26.29415 -0.20492  1.000 27.05604  ?  204 PHE A CZ   1 
ATOM   1944 H H    A PHE A 1 123 ? 14.10971  -26.61597 -1.21848  0.740 21.82316  ?  204 PHE A H    1 
ATOM   1945 D D    B PHE A 1 123 ? 14.11006  -26.61549 -1.21589  0.260 21.82316  ?  204 PHE A D    1 
ATOM   1946 H HA   . PHE A 1 123 ? 12.38804  -28.93307 -1.83414  1.000 23.04338  ?  204 PHE A HA   1 
ATOM   1947 H HB2  . PHE A 1 123 ? 12.30206  -26.18485 -3.13662  1.000 23.27468  ?  204 PHE A HB2  1 
ATOM   1948 H HB3  . PHE A 1 123 ? 11.43680  -27.63557 -3.71596  1.000 23.27468  ?  204 PHE A HB3  1 
ATOM   1949 H HD1  . PHE A 1 123 ? 9.73514   -28.67208 -2.29635  1.000 35.60489  ?  204 PHE A HD1  1 
ATOM   1950 H HD2  . PHE A 1 123 ? 11.46349  -24.90887 -1.35100  1.000 32.95430  ?  204 PHE A HD2  1 
ATOM   1951 H HE1  . PHE A 1 123 ? 7.87553   -28.20416 -0.75501  1.000 35.32192  ?  204 PHE A HE1  1 
ATOM   1952 H HE2  . PHE A 1 123 ? 9.59893   -24.43947 0.17876   1.000 37.49216  ?  204 PHE A HE2  1 
ATOM   1953 H HZ   . PHE A 1 123 ? 7.83811   -26.08952 0.47837   1.000 32.46724  ?  204 PHE A HZ   1 
ATOM   1954 N N    . PRO A 1 124 ? 14.81141  -29.38211 -2.73929  1.000 20.29835  ?  205 PRO A N    1 
ATOM   1955 C CA   . PRO A 1 124 ? 15.92682  -29.77579 -3.60933  1.000 23.05389  ?  205 PRO A CA   1 
ATOM   1956 C C    . PRO A 1 124 ? 15.49938  -30.44829 -4.90874  1.000 19.57114  ?  205 PRO A C    1 
ATOM   1957 O O    . PRO A 1 124 ? 16.32991  -30.57633 -5.81933  1.000 23.01131  ?  205 PRO A O    1 
ATOM   1958 C CB   . PRO A 1 124 ? 16.73092  -30.73054 -2.73128  1.000 23.59288  ?  205 PRO A CB   1 
ATOM   1959 C CG   . PRO A 1 124 ? 15.71326  -31.28873 -1.80884  1.000 26.72734  ?  205 PRO A CG   1 
ATOM   1960 C CD   . PRO A 1 124 ? 14.72402  -30.22436 -1.52843  1.000 22.59736  ?  205 PRO A CD   1 
ATOM   1961 H HA   . PRO A 1 124 ? 16.53663  -28.90444 -3.84803  1.000 27.66467  ?  205 PRO A HA   1 
ATOM   1962 H HB2  . PRO A 1 124 ? 17.18555  -31.51208 -3.34006  1.000 28.31145  ?  205 PRO A HB2  1 
ATOM   1963 H HB3  . PRO A 1 124 ? 17.50244  -30.18531 -2.18759  1.000 28.31145  ?  205 PRO A HB3  1 
ATOM   1964 H HG2  . PRO A 1 124 ? 15.22719  -32.14066 -2.28430  1.000 32.07281  ?  205 PRO A HG2  1 
ATOM   1965 H HG3  . PRO A 1 124 ? 16.20033  -31.60453 -0.88627  1.000 32.07281  ?  205 PRO A HG3  1 
ATOM   1966 H HD2  . PRO A 1 124 ? 13.72331  -30.64050 -1.41220  1.000 27.11683  ?  205 PRO A HD2  1 
ATOM   1967 H HD3  . PRO A 1 124 ? 14.99857  -29.65932 -0.63767  1.000 27.11683  ?  205 PRO A HD3  1 
ATOM   1968 N N    . ASP A 1 125 ? 14.24121  -30.86087 -5.03072  1.000 18.85131  ?  206 ASP A N    1 
ATOM   1969 C CA   . ASP A 1 125 ? 13.73829  -31.48413 -6.24484  1.000 16.00033  ?  206 ASP A CA   1 
ATOM   1970 C C    . ASP A 1 125 ? 13.36345  -30.48033 -7.32200  1.000 16.56816  ?  206 ASP A C    1 
ATOM   1971 O O    . ASP A 1 125 ? 13.03761  -30.88408 -8.44845  1.000 19.24553  ?  206 ASP A O    1 
ATOM   1972 C CB   . ASP A 1 125 ? 12.50523  -32.34187 -5.94524  1.000 19.99797  ?  206 ASP A CB   1 
ATOM   1973 C CG   . ASP A 1 125 ? 11.41896  -31.57469 -5.23562  1.000 19.89000  ?  206 ASP A CG   1 
ATOM   1974 O OD1  . ASP A 1 125 ? 11.72673  -30.77871 -4.28472  1.000 24.07536  ?  206 ASP A OD1  1 
ATOM   1975 O OD2  . ASP A 1 125 ? 10.24452  -31.78355 -5.61825  1.000 28.41277  -1 206 ASP A OD2  1 
ATOM   1976 H H    A ASP A 1 125 ? 13.53893  -30.77538 -4.29595  0.070 22.62158  ?  206 ASP A H    1 
ATOM   1977 D D    B ASP A 1 125 ? 13.53878  -30.77548 -4.29609  0.930 22.62158  ?  206 ASP A D    1 
ATOM   1978 H HA   . ASP A 1 125 ? 14.52604  -32.13294 -6.62771  1.000 19.20040  ?  206 ASP A HA   1 
ATOM   1979 H HB2  . ASP A 1 125 ? 12.09585  -32.71530 -6.88388  1.000 23.99756  ?  206 ASP A HB2  1 
ATOM   1980 H HB3  . ASP A 1 125 ? 12.79931  -33.17633 -5.30860  1.000 23.99756  ?  206 ASP A HB3  1 
ATOM   1981 N N    . VAL A 1 126 ? 13.41143  -29.19306 -7.02779  1.000 15.26406  ?  207 VAL A N    1 
ATOM   1982 C CA   . VAL A 1 126 ? 13.08507  -28.14523 -7.99394  1.000 15.57793  ?  207 VAL A CA   1 
ATOM   1983 C C    . VAL A 1 126 ? 14.38973  -27.46754 -8.40282  1.000 14.13311  ?  207 VAL A C    1 
ATOM   1984 O O    . VAL A 1 126 ? 15.18989  -27.09477 -7.54217  1.000 17.57472  ?  207 VAL A O    1 
ATOM   1985 C CB   . VAL A 1 126 ? 12.11590  -27.13279 -7.37329  1.000 13.62595  ?  207 VAL A CB   1 
ATOM   1986 C CG1  . VAL A 1 126 ? 11.85140  -25.98248 -8.31307  1.000 17.38137  ?  207 VAL A CG1  1 
ATOM   1987 C CG2  . VAL A 1 126 ? 10.80195  -27.82321 -7.01268  1.000 17.24514  ?  207 VAL A CG2  1 
ATOM   1988 H H    A VAL A 1 126 ? 13.67749  -28.83179 -6.11177  0.740 18.31687  ?  207 VAL A H    1 
ATOM   1989 D D    B VAL A 1 126 ? 13.67785  -28.83436 -6.11086  0.260 18.31687  ?  207 VAL A D    1 
ATOM   1990 H HA   . VAL A 1 126 ? 12.62595  -28.57712 -8.88320  1.000 18.69352  ?  207 VAL A HA   1 
ATOM   1991 H HB   . VAL A 1 126 ? 12.57020  -26.72896 -6.46851  1.000 16.35115  ?  207 VAL A HB   1 
ATOM   1992 H HG11 . VAL A 1 126 ? 12.79807  -25.50338 -8.56281  1.000 20.85764  ?  207 VAL A HG11 1 
ATOM   1993 H HG12 . VAL A 1 126 ? 11.37828  -26.36477 -9.21756  1.000 20.85764  ?  207 VAL A HG12 1 
ATOM   1994 H HG13 . VAL A 1 126 ? 11.19120  -25.26760 -7.82195  1.000 20.85764  ?  207 VAL A HG13 1 
ATOM   1995 H HG21 . VAL A 1 126 ? 10.11402  -27.08440 -6.60158  1.000 20.69417  ?  207 VAL A HG21 1 
ATOM   1996 H HG22 . VAL A 1 126 ? 10.37605  -28.26762 -7.91224  1.000 20.69417  ?  207 VAL A HG22 1 
ATOM   1997 H HG23 . VAL A 1 126 ? 11.00000  -28.59883 -6.27289  1.000 20.69417  ?  207 VAL A HG23 1 
ATOM   1998 N N    . ARG A 1 127 ? 14.58911  -27.29544 -9.70097  1.000 12.46495  ?  208 ARG A N    1 
ATOM   1999 C CA   . ARG A 1 127 ? 15.76435  -26.59030 -10.20316 1.000 11.56764  ?  208 ARG A CA   1 
ATOM   2000 C C    . ARG A 1 127 ? 15.45414  -25.10282 -10.23885 1.000 11.47676  ?  208 ARG A C    1 
ATOM   2001 O O    . ARG A 1 127 ? 14.34787  -24.69400 -10.60378 1.000 13.61943  ?  208 ARG A O    1 
ATOM   2002 C CB   . ARG A 1 127 ? 16.10704  -27.07024 -11.61198 1.000 12.86465  ?  208 ARG A CB   1 
ATOM   2003 C CG   . ARG A 1 127 ? 17.29190  -26.32287 -12.20274 1.000 13.41161  ?  208 ARG A CG   1 
ATOM   2004 C CD   . ARG A 1 127 ? 17.91891  -27.07811 -13.34549 1.000 16.03681  ?  208 ARG A CD   1 
ATOM   2005 N NE   . ARG A 1 127 ? 18.69991  -28.22511 -12.90636 1.000 14.37568  ?  208 ARG A NE   1 
ATOM   2006 C CZ   . ARG A 1 127 ? 19.38352  -28.97351 -13.76782 1.000 16.71563  ?  208 ARG A CZ   1 
ATOM   2007 N NH1  . ARG A 1 127 ? 19.34207  -28.72696 -15.08572 1.000 15.28553  ?  208 ARG A NH1  1 
ATOM   2008 N NH2  . ARG A 1 127 ? 20.10731  -30.00457 -13.29868 1.000 18.07950  ?  208 ARG A NH2  1 
ATOM   2009 H H    A ARG A 1 127 ? 13.95897  -27.63035 -10.42978 0.940 14.95794  ?  208 ARG A H    1 
ATOM   2010 D D    B ARG A 1 127 ? 13.95853  -27.63062 -10.42928 0.060 14.95794  ?  208 ARG A D    1 
ATOM   2011 H HA   . ARG A 1 127 ? 16.62524  -26.77350 -9.56019  1.000 13.88117  ?  208 ARG A HA   1 
ATOM   2012 H HB2  . ARG A 1 127 ? 16.35726  -28.13054 -11.57676 1.000 15.43759  ?  208 ARG A HB2  1 
ATOM   2013 H HB3  . ARG A 1 127 ? 15.24668  -26.91162 -12.26215 1.000 15.43759  ?  208 ARG A HB3  1 
ATOM   2014 H HG2  . ARG A 1 127 ? 16.95644  -25.35560 -12.57685 1.000 16.09393  ?  208 ARG A HG2  1 
ATOM   2015 H HG3  . ARG A 1 127 ? 18.04891  -26.18204 -11.43124 1.000 16.09393  ?  208 ARG A HG3  1 
ATOM   2016 H HD2  . ARG A 1 127 ? 17.13103  -27.44091 -14.00558 1.000 19.24417  ?  208 ARG A HD2  1 
ATOM   2017 H HD3  . ARG A 1 127 ? 18.58339  -26.40821 -13.89121 1.000 19.24417  ?  208 ARG A HD3  1 
ATOM   2018 N N    . VAL A 1 128 ? 16.43624  -24.29024 -9.87025  1.000 11.36182  ?  209 VAL A N    1 
ATOM   2019 C CA   . VAL A 1 128 ? 16.31573  -22.84366 -9.88515  1.000 11.66459  ?  209 VAL A CA   1 
ATOM   2020 C C    . VAL A 1 128 ? 17.37701  -22.28012 -10.80773 1.000 11.21503  ?  209 VAL A C    1 
ATOM   2021 O O    . VAL A 1 128 ? 18.55585  -22.66800 -10.72668 1.000 12.12970  ?  209 VAL A O    1 
ATOM   2022 C CB   . VAL A 1 128 ? 16.45264  -22.25594 -8.47180  1.000 11.91440  ?  209 VAL A CB   1 
ATOM   2023 C CG1  . VAL A 1 128 ? 16.28618  -20.74443 -8.50647  1.000 12.76839  ?  209 VAL A CG1  1 
ATOM   2024 C CG2  . VAL A 1 128 ? 15.40841  -22.87095 -7.55290  1.000 16.36272  ?  209 VAL A CG2  1 
ATOM   2025 H H    A VAL A 1 128 ? 17.34795  -24.61603 -9.54925  0.940 13.63419  ?  209 VAL A H    1 
ATOM   2026 D D    B VAL A 1 128 ? 17.34716  -24.61856 -9.54959  0.060 13.63419  ?  209 VAL A D    1 
ATOM   2027 H HA   . VAL A 1 128 ? 15.33968  -22.56737 -10.28401 1.000 13.99751  ?  209 VAL A HA   1 
ATOM   2028 H HB   . VAL A 1 128 ? 17.44580  -22.48501 -8.08546  1.000 14.29728  ?  209 VAL A HB   1 
ATOM   2029 H HG11 . VAL A 1 128 ? 15.37055  -20.50052 -9.04519  1.000 15.32207  ?  209 VAL A HG11 1 
ATOM   2030 H HG12 . VAL A 1 128 ? 16.22692  -20.37040 -7.48436  1.000 15.32207  ?  209 VAL A HG12 1 
ATOM   2031 H HG13 . VAL A 1 128 ? 17.14455  -20.30443 -9.01411  1.000 15.32207  ?  209 VAL A HG13 1 
ATOM   2032 H HG21 . VAL A 1 128 ? 15.72894  -22.74719 -6.51847  1.000 19.63526  ?  209 VAL A HG21 1 
ATOM   2033 H HG22 . VAL A 1 128 ? 14.45564  -22.36527 -7.70983  1.000 19.63526  ?  209 VAL A HG22 1 
ATOM   2034 H HG23 . VAL A 1 128 ? 15.30967  -23.93089 -7.78716  1.000 19.63526  ?  209 VAL A HG23 1 
ATOM   2035 N N    . VAL A 1 129 ? 16.94752  -21.39959 -11.69167 1.000 10.34514  ?  210 VAL A N    1 
ATOM   2036 C CA   . VAL A 1 129 ? 17.84102  -20.59603 -12.50784 1.000 10.98874  ?  210 VAL A CA   1 
ATOM   2037 C C    . VAL A 1 129 ? 17.65292  -19.15467 -12.09160 1.000 10.49040  ?  210 VAL A C    1 
ATOM   2038 O O    . VAL A 1 129 ? 16.51598  -18.65802 -12.04414 1.000 11.72382  ?  210 VAL A O    1 
ATOM   2039 C CB   . VAL A 1 129 ? 17.55591  -20.77719 -14.01062 1.000 11.32845  ?  210 VAL A CB   1 
ATOM   2040 C CG1  . VAL A 1 129 ? 18.40162  -19.78822 -14.80875 1.000 15.88120  ?  210 VAL A CG1  1 
ATOM   2041 C CG2  . VAL A 1 129 ? 17.82328  -22.19125 -14.43473 1.000 15.84156  ?  210 VAL A CG2  1 
ATOM   2042 H H    A VAL A 1 129 ? 15.96054  -21.21463 -11.87072 1.000 12.41417  ?  210 VAL A H    1 
ATOM   2043 D D    B VAL A 1 129 ? 15.95985  -21.21650 -11.86882 0.000 12.41417  ?  210 VAL A D    1 
ATOM   2044 H HA   . VAL A 1 129 ? 18.87467  -20.89036 -12.32605 1.000 13.18649  ?  210 VAL A HA   1 
ATOM   2045 H HB   . VAL A 1 129 ? 16.50406  -20.57539 -14.21308 1.000 13.59414  ?  210 VAL A HB   1 
ATOM   2046 H HG11 . VAL A 1 129 ? 19.41120  -20.18622 -14.91089 1.000 19.05744  ?  210 VAL A HG11 1 
ATOM   2047 H HG12 . VAL A 1 129 ? 17.95421  -19.65248 -15.79338 1.000 19.05744  ?  210 VAL A HG12 1 
ATOM   2048 H HG13 . VAL A 1 129 ? 18.42924  -18.83624 -14.27859 1.000 19.05744  ?  210 VAL A HG13 1 
ATOM   2049 H HG21 . VAL A 1 129 ? 17.21575  -22.86414 -13.82956 1.000 19.00987  ?  210 VAL A HG21 1 
ATOM   2050 H HG22 . VAL A 1 129 ? 17.56322  -22.30118 -15.48753 1.000 19.00987  ?  210 VAL A HG22 1 
ATOM   2051 H HG23 . VAL A 1 129 ? 18.88060  -22.41184 -14.28805 1.000 19.00987  ?  210 VAL A HG23 1 
ATOM   2052 N N    . ALA A 1 130 ? 18.74610  -18.46732 -11.83048 1.000 10.46024  ?  211 ALA A N    1 
ATOM   2053 C CA   . ALA A 1 130 ? 18.72031  -17.08963 -11.37759 1.000 10.56181  ?  211 ALA A CA   1 
ATOM   2054 C C    . ALA A 1 130 ? 19.53622  -16.16528 -12.26929 1.000 10.89598  ?  211 ALA A C    1 
ATOM   2055 O O    . ALA A 1 130 ? 20.67988  -16.49362 -12.63143 1.000 13.03798  ?  211 ALA A O    1 
ATOM   2056 C CB   . ALA A 1 130 ? 19.27693  -16.97083 -9.95839  1.000 12.49991  ?  211 ALA A CB   1 
ATOM   2057 H H    A ALA A 1 130 ? 19.68864  -18.84558 -11.92507 0.830 12.55229  ?  211 ALA A H    1 
ATOM   2058 D D    B ALA A 1 130 ? 19.68773  -18.84767 -11.92579 0.170 12.55229  ?  211 ALA A D    1 
ATOM   2059 H HA   . ALA A 1 130 ? 17.67990  -16.76818 -11.42585 1.000 12.67417  ?  211 ALA A HA   1 
ATOM   2060 H HB1  . ALA A 1 130 ? 18.87776  -17.78348 -9.35146  1.000 14.99989  ?  211 ALA A HB1  1 
ATOM   2061 H HB2  . ALA A 1 130 ? 20.36433  -17.03534 -9.99714  1.000 14.99989  ?  211 ALA A HB2  1 
ATOM   2062 H HB3  . ALA A 1 130 ? 18.97626  -16.01096 -9.53847  1.000 14.99989  ?  211 ALA A HB3  1 
ATOM   2063 N N    . VAL A 1 131 ? 18.97285  -15.02124 -12.60319 1.000 10.16965  ?  212 VAL A N    1 
ATOM   2064 C CA   . VAL A 1 131 ? 19.70227  -13.90592 -13.17163 1.000 9.37055   ?  212 VAL A CA   1 
ATOM   2065 C C    . VAL A 1 131 ? 20.15738  -13.05255 -11.99691 1.000 9.48953   ?  212 VAL A C    1 
ATOM   2066 O O    . VAL A 1 131 ? 19.34178  -12.68744 -11.12966 1.000 11.15463  ?  212 VAL A O    1 
ATOM   2067 C CB   . VAL A 1 131 ? 18.83694  -13.08482 -14.14501 1.000 10.84220  ?  212 VAL A CB   1 
ATOM   2068 C CG1  . VAL A 1 131 ? 19.49685  -11.77866 -14.50051 1.000 12.41132  ?  212 VAL A CG1  1 
ATOM   2069 C CG2  . VAL A 1 131 ? 18.51902  -13.89820 -15.41397 1.000 12.57887  ?  212 VAL A CG2  1 
ATOM   2070 H H    A VAL A 1 131 ? 17.97778  -14.82883 -12.48829 1.000 12.20358  ?  212 VAL A H    1 
ATOM   2071 D D    B VAL A 1 131 ? 17.97761  -14.83000 -12.48781 0.000 12.20358  ?  212 VAL A D    1 
ATOM   2072 H HA   . VAL A 1 131 ? 20.56025  -14.26720 -13.73860 1.000 11.24467  ?  212 VAL A HA   1 
ATOM   2073 H HB   . VAL A 1 131 ? 17.89637  -12.85177 -13.64590 1.000 13.01065  ?  212 VAL A HB   1 
ATOM   2074 H HG11 . VAL A 1 131 ? 20.32113  -11.97275 -15.18680 1.000 14.89359  ?  212 VAL A HG11 1 
ATOM   2075 H HG12 . VAL A 1 131 ? 18.76280  -11.12801 -14.97582 1.000 14.89359  ?  212 VAL A HG12 1 
ATOM   2076 H HG13 . VAL A 1 131 ? 19.87313  -11.31186 -13.59023 1.000 14.89359  ?  212 VAL A HG13 1 
ATOM   2077 H HG21 . VAL A 1 131 ? 18.48492  -14.95705 -15.15751 1.000 15.09465  ?  212 VAL A HG21 1 
ATOM   2078 H HG22 . VAL A 1 131 ? 17.55354  -13.57969 -15.80704 1.000 15.09465  ?  212 VAL A HG22 1 
ATOM   2079 H HG23 . VAL A 1 131 ? 19.29888  -13.72001 -16.15436 1.000 15.09465  ?  212 VAL A HG23 1 
ATOM   2080 N N    . ILE A 1 132 ? 21.44479  -12.77057 -11.91258 1.000 8.90395   ?  213 ILE A N    1 
ATOM   2081 C CA   . ILE A 1 132 ? 22.03598  -12.04998 -10.78984 1.000 10.09451  ?  213 ILE A CA   1 
ATOM   2082 C C    . ILE A 1 132 ? 22.18618  -10.56541 -11.13573 1.000 10.44876  ?  213 ILE A C    1 
ATOM   2083 O O    . ILE A 1 132 ? 23.03443  -10.17241 -11.94772 1.000 11.04871  ?  213 ILE A O    1 
ATOM   2084 C CB   . ILE A 1 132 ? 23.40090  -12.64024 -10.40490 1.000 10.71269  ?  213 ILE A CB   1 
ATOM   2085 C CG1  . ILE A 1 132 ? 23.28438  -14.14127 -10.14462 1.000 12.50117  ?  213 ILE A CG1  1 
ATOM   2086 C CG2  . ILE A 1 132 ? 23.98968  -11.88639 -9.20316  1.000 12.50552  ?  213 ILE A CG2  1 
ATOM   2087 C CD1  . ILE A 1 132 ? 22.42163  -14.54619 -9.02370  1.000 16.92930  ?  213 ILE A CD1  1 
ATOM   2088 H H    A ILE A 1 132 ? 22.12686  -13.03346 -12.62396 1.000 10.68474  ?  213 ILE A H    1 
ATOM   2089 D D    B ILE A 1 132 ? 22.12519  -13.03445 -12.62520 0.000 10.68474  ?  213 ILE A D    1 
ATOM   2090 H HA   . ILE A 1 132 ? 21.34036  -12.12437 -9.95397  1.000 12.11341  ?  213 ILE A HA   1 
ATOM   2091 H HB   . ILE A 1 132 ? 24.08856  -12.51229 -11.24088 1.000 12.85522  ?  213 ILE A HB   1 
ATOM   2092 H HG12 . ILE A 1 132 ? 22.88320  -14.61077 -11.04280 1.000 15.00140  ?  213 ILE A HG12 1 
ATOM   2093 H HG13 . ILE A 1 132 ? 24.28211  -14.52743 -9.93599  1.000 15.00140  ?  213 ILE A HG13 1 
ATOM   2094 H HG21 . ILE A 1 132 ? 23.28157  -11.12258 -8.88180  1.000 15.00663  ?  213 ILE A HG21 1 
ATOM   2095 H HG22 . ILE A 1 132 ? 24.16683  -12.59354 -8.39281  1.000 15.00663  ?  213 ILE A HG22 1 
ATOM   2096 H HG23 . ILE A 1 132 ? 24.92874  -11.42055 -9.50190  1.000 15.00663  ?  213 ILE A HG23 1 
ATOM   2097 H HD11 . ILE A 1 132 ? 22.59878  -13.87866 -8.18041  1.000 20.31516  ?  213 ILE A HD11 1 
ATOM   2098 H HD12 . ILE A 1 132 ? 21.37952  -14.48134 -9.33656  1.000 20.31516  ?  213 ILE A HD12 1 
ATOM   2099 H HD13 . ILE A 1 132 ? 22.66234  -15.57157 -8.74304  1.000 20.31516  ?  213 ILE A HD13 1 
ATOM   2100 N N    . GLU A 1 133 ? 21.35343  -9.73453  -10.51220 1.000 9.40278   ?  214 GLU A N    1 
ATOM   2101 C CA   . GLU A 1 133 ? 21.52574  -8.28817  -10.34757 1.000 8.70744   ?  214 GLU A CA   1 
ATOM   2102 C C    . GLU A 1 133 ? 21.68191  -7.55803  -11.66775 1.000 9.49582   ?  214 GLU A C    1 
ATOM   2103 O O    . GLU A 1 133 ? 22.75344  -7.01944  -11.98945 1.000 9.96084   ?  214 GLU A O    1 
ATOM   2104 C CB   . GLU A 1 133 ? 22.64846  -7.96276  -9.35055  1.000 9.49615   ?  214 GLU A CB   1 
ATOM   2105 C CG   . GLU A 1 133 ? 22.33212  -8.43713  -7.94195  1.000 9.61291   ?  214 GLU A CG   1 
ATOM   2106 C CD   . GLU A 1 133 ? 21.20972  -7.67728  -7.24026  1.000 10.54441  ?  214 GLU A CD   1 
ATOM   2107 O OE1  . GLU A 1 133 ? 20.76293  -6.61427  -7.70522  1.000 10.98141  ?  214 GLU A OE1  1 
ATOM   2108 O OE2  . GLU A 1 133 ? 20.75193  -8.18982  -6.18769  1.000 10.95796  -1 214 GLU A OE2  1 
ATOM   2109 H H    A GLU A 1 133 ? 20.48692  -10.05230 -10.07793 0.950 11.28333  ?  214 GLU A H    1 
ATOM   2110 D D    B GLU A 1 133 ? 20.48696  -10.05249 -10.07799 0.050 11.28333  ?  214 GLU A D    1 
ATOM   2111 H HA   . GLU A 1 133 ? 20.60196  -7.89537  -9.92278  1.000 10.44893  ?  214 GLU A HA   1 
ATOM   2112 H HB2  . GLU A 1 133 ? 23.56580  -8.45388  -9.67520  1.000 11.39538  ?  214 GLU A HB2  1 
ATOM   2113 H HB3  . GLU A 1 133 ? 22.79456  -6.88305  -9.31940  1.000 11.39538  ?  214 GLU A HB3  1 
ATOM   2114 H HG2  . GLU A 1 133 ? 22.03636  -9.48518  -7.98899  1.000 11.53549  ?  214 GLU A HG2  1 
ATOM   2115 H HG3  . GLU A 1 133 ? 23.22914  -8.32992  -7.33207  1.000 11.53549  ?  214 GLU A HG3  1 
ATOM   2116 N N    . PRO A 1 134 ? 20.57944  -7.41873  -12.40804 1.000 10.05904  ?  215 PRO A N    1 
ATOM   2117 C CA   . PRO A 1 134 ? 20.56055  -6.47243  -13.52282 1.000 10.73897  ?  215 PRO A CA   1 
ATOM   2118 C C    . PRO A 1 134 ? 21.04434  -5.09529  -13.11230 1.000 11.19970  ?  215 PRO A C    1 
ATOM   2119 O O    . PRO A 1 134 ? 20.83593  -4.64762  -11.98756 1.000 11.97356  ?  215 PRO A O    1 
ATOM   2120 C CB   . PRO A 1 134 ? 19.07682  -6.43176  -13.91067 1.000 12.49174  ?  215 PRO A CB   1 
ATOM   2121 C CG   . PRO A 1 134 ? 18.52452  -7.77073  -13.43460 1.000 13.53787  ?  215 PRO A CG   1 
ATOM   2122 C CD   . PRO A 1 134 ? 19.26787  -8.03885  -12.16879 1.000 11.04626  ?  215 PRO A CD   1 
ATOM   2123 H HA   . PRO A 1 134 ? 21.17107  -6.84402  -14.34580 1.000 12.88676  ?  215 PRO A HA   1 
ATOM   2124 H HB2  . PRO A 1 134 ? 18.58147  -5.60141  -13.40743 1.000 14.99009  ?  215 PRO A HB2  1 
ATOM   2125 H HB3  . PRO A 1 134 ? 18.97549  -6.32692  -14.99087 1.000 14.99009  ?  215 PRO A HB3  1 
ATOM   2126 H HG2  . PRO A 1 134 ? 17.45273  -7.69201  -13.25248 1.000 16.24545  ?  215 PRO A HG2  1 
ATOM   2127 H HG3  . PRO A 1 134 ? 18.72064  -8.54387  -14.17749 1.000 16.24545  ?  215 PRO A HG3  1 
ATOM   2128 H HD2  . PRO A 1 134 ? 18.76793  -7.57327  -11.31943 1.000 13.25551  ?  215 PRO A HD2  1 
ATOM   2129 H HD3  . PRO A 1 134 ? 19.37082  -9.11063  -11.99911 1.000 13.25551  ?  215 PRO A HD3  1 
ATOM   2130 N N    . ASP A 1 135 ? 21.65345  -4.38632  -14.05756 1.000 10.67277  ?  216 ASP A N    1 
ATOM   2131 C CA   . ASP A 1 135 ? 22.03036  -2.98675  -13.86427 1.000 12.31523  ?  216 ASP A CA   1 
ATOM   2132 C C    . ASP A 1 135 ? 22.96475  -2.80908  -12.66407 1.000 12.32569  ?  216 ASP A C    1 
ATOM   2133 O O    . ASP A 1 135 ? 22.84166  -1.83824  -11.92018 1.000 13.41935  ?  216 ASP A O    1 
ATOM   2134 C CB   . ASP A 1 135 ? 20.79750  -2.08598  -13.71599 1.000 13.74204  ?  216 ASP A CB   1 
ATOM   2135 C CG   . ASP A 1 135 ? 21.11872  -0.62273  -13.83698 1.000 13.49241  ?  216 ASP A CG   1 
ATOM   2136 O OD1  . ASP A 1 135 ? 22.00022  -0.26698  -14.53903 1.000 15.98323  ?  216 ASP A OD1  1 
ATOM   2137 O OD2  . ASP A 1 135 ? 20.38144  0.21051   -13.11998 1.000 15.28628  -1 216 ASP A OD2  1 
ATOM   2138 H H    A ASP A 1 135 ? 21.90202  -4.75446  -14.97576 0.130 12.80732  ?  216 ASP A H    1 
ATOM   2139 D D    B ASP A 1 135 ? 21.90167  -4.75527  -14.97553 0.870 12.80732  ?  216 ASP A D    1 
ATOM   2140 H HA   . ASP A 1 135 ? 22.57643  -2.67167  -14.75345 1.000 14.77828  ?  216 ASP A HA   1 
ATOM   2141 H HB2  . ASP A 1 135 ? 20.07961  -2.33751  -14.49668 1.000 16.49045  ?  216 ASP A HB2  1 
ATOM   2142 H HB3  . ASP A 1 135 ? 20.35405  -2.25203  -12.73421 1.000 16.49045  ?  216 ASP A HB3  1 
ATOM   2143 D DD2  . ASP A 1 135 ? 19.72226  -0.33838  -12.56807 0.740 18.34353  ?  216 ASP A DD2  1 
ATOM   2144 N N    . SER A 1 136 ? 23.94170  -3.70874  -12.50797 1.000 11.90373  ?  217 SER A N    1 
ATOM   2145 C CA   . SER A 1 136 ? 24.90837  -3.63823  -11.42566 1.000 11.35002  ?  217 SER A CA   1 
ATOM   2146 C C    . SER A 1 136 ? 26.32314  -3.56497  -11.97964 1.000 12.08420  ?  217 SER A C    1 
ATOM   2147 O O    . SER A 1 136 ? 26.85762  -2.45873  -12.16569 1.000 13.24926  ?  217 SER A O    1 
ATOM   2148 C CB   . SER A 1 136 ? 24.70237  -4.80201  -10.42335 1.000 11.97327  ?  217 SER A CB   1 
ATOM   2149 O OG   . SER A 1 136 ? 24.99925  -6.04620  -10.96753 1.000 13.48506  ?  217 SER A OG   1 
ATOM   2150 H H    A SER A 1 136 ? 24.08537  -4.50624  -13.12744 0.410 14.28448  ?  217 SER A H    1 
ATOM   2151 D D    B SER A 1 136 ? 24.08561  -4.50633  -13.12728 0.590 14.28448  ?  217 SER A D    1 
ATOM   2152 H HA   . SER A 1 136 ? 24.75678  -2.72587  -10.84885 1.000 13.62002  ?  217 SER A HA   1 
ATOM   2153 H HB2  . SER A 1 136 ? 25.35280  -4.63692  -9.56440  1.000 14.36792  ?  217 SER A HB2  1 
ATOM   2154 H HB3  . SER A 1 136 ? 23.65948  -4.80393  -10.10634 1.000 14.36792  ?  217 SER A HB3  1 
ATOM   2155 H HG   A SER A 1 136 ? 24.18220  -6.46660  -11.30827 0.120 16.18207  ?  217 SER A HG   1 
ATOM   2156 D DG   B SER A 1 136 ? 24.17172  -6.51356  -11.20663 0.880 16.18207  ?  217 SER A DG   1 
ATOM   2157 N N    . LEU A 1 137 ? 26.92536  -4.71282  -12.27015 1.000 10.80048  ?  218 LEU A N    1 
ATOM   2158 C CA   . LEU A 1 137 ? 28.33492  -4.74542  -12.63134 1.000 12.75045  ?  218 LEU A CA   1 
ATOM   2159 C C    . LEU A 1 137 ? 28.62503  -4.02212  -13.93184 1.000 12.50306  ?  218 LEU A C    1 
ATOM   2160 O O    . LEU A 1 137 ? 29.73939  -3.49577  -14.08489 1.000 13.22508  ?  218 LEU A O    1 
ATOM   2161 C CB   . LEU A 1 137 ? 28.84531  -6.19040  -12.70142 1.000 15.60470  ?  218 LEU A CB   1 
ATOM   2162 C CG   . LEU A 1 137 ? 28.68272  -6.99439  -11.39581 1.000 16.86043  ?  218 LEU A CG   1 
ATOM   2163 C CD1  . LEU A 1 137 ? 29.15614  -8.42303  -11.69278 1.000 20.92164  ?  218 LEU A CD1  1 
ATOM   2164 C CD2  . LEU A 1 137 ? 29.43234  -6.36365  -10.29247 1.000 20.22027  ?  218 LEU A CD2  1 
ATOM   2165 H H    A LEU A 1 137 ? 26.47100  -5.62601  -12.26467 1.000 12.96057  ?  218 LEU A H    1 
ATOM   2166 D D    B LEU A 1 137 ? 26.47328  -5.62715  -12.26538 0.000 12.96057  ?  218 LEU A D    1 
ATOM   2167 H HA   . LEU A 1 137 ? 28.88572  -4.23256  -11.84286 1.000 15.30054  ?  218 LEU A HA   1 
ATOM   2168 H HB2  . LEU A 1 137 ? 28.29330  -6.71452  -13.48161 1.000 18.72564  ?  218 LEU A HB2  1 
ATOM   2169 H HB3  . LEU A 1 137 ? 29.90744  -6.17038  -12.94552 1.000 18.72564  ?  218 LEU A HB3  1 
ATOM   2170 H HG   . LEU A 1 137 ? 27.64676  -7.02011  -11.05781 1.000 20.23252  ?  218 LEU A HG   1 
ATOM   2171 H HD11 . LEU A 1 137 ? 28.29851  -9.02646  -11.99018 1.000 25.10597  ?  218 LEU A HD11 1 
ATOM   2172 H HD12 . LEU A 1 137 ? 29.88791  -8.39377  -12.50009 1.000 25.10597  ?  218 LEU A HD12 1 
ATOM   2173 H HD13 . LEU A 1 137 ? 29.61054  -8.84030  -10.79417 1.000 25.10597  ?  218 LEU A HD13 1 
ATOM   2174 H HD21 . LEU A 1 137 ? 29.04861  -6.73777  -9.34332  1.000 24.26432  ?  218 LEU A HD21 1 
ATOM   2175 H HD22 . LEU A 1 137 ? 30.48829  -6.61515  -10.39155 1.000 24.26432  ?  218 LEU A HD22 1 
ATOM   2176 H HD23 . LEU A 1 137 ? 29.30099  -5.28294  -10.34646 1.000 24.26432  ?  218 LEU A HD23 1 
ATOM   2177 N N    . ALA A 1 138 ? 27.67132  -3.95519  -14.85252 1.000 11.06153  ?  219 ALA A N    1 
ATOM   2178 C CA   . ALA A 1 138 ? 27.93232  -3.22555  -16.09316 1.000 12.02133  ?  219 ALA A CA   1 
ATOM   2179 C C    . ALA A 1 138 ? 28.26903  -1.76218  -15.80277 1.000 13.30276  ?  219 ALA A C    1 
ATOM   2180 O O    . ALA A 1 138 ? 29.06081  -1.13353  -16.52808 1.000 13.13964  ?  219 ALA A O    1 
ATOM   2181 C CB   . ALA A 1 138 ? 26.71034  -3.33709  -16.99517 1.000 13.54280  ?  219 ALA A CB   1 
ATOM   2182 H H    A ALA A 1 138 ? 26.74507  -4.37576  -14.77769 0.000 13.27383  ?  219 ALA A H    1 
ATOM   2183 D D    B ALA A 1 138 ? 26.74447  -4.37483  -14.78005 1.000 13.27383  ?  219 ALA A D    1 
ATOM   2184 H HA   . ALA A 1 138 ? 28.78240  -3.66163  -16.61785 1.000 14.42559  ?  219 ALA A HA   1 
ATOM   2185 H HB1  . ALA A 1 138 ? 25.93017  -2.67518  -16.61926 1.000 16.25136  ?  219 ALA A HB1  1 
ATOM   2186 H HB2  . ALA A 1 138 ? 26.98898  -3.04564  -18.00785 1.000 16.25136  ?  219 ALA A HB2  1 
ATOM   2187 H HB3  . ALA A 1 138 ? 26.35763  -4.36843  -16.98896 1.000 16.25136  ?  219 ALA A HB3  1 
ATOM   2188 N N    . ASN A 1 139 ? 27.71191  -1.19091  -14.72470 1.000 12.32164  ?  220 ASN A N    1 
ATOM   2189 C CA   . ASN A 1 139 ? 28.05271  0.17427   -14.36072 1.000 12.77704  ?  220 ASN A CA   1 
ATOM   2190 C C    . ASN A 1 139 ? 29.50116  0.33013   -13.95177 1.000 13.66063  ?  220 ASN A C    1 
ATOM   2191 O O    . ASN A 1 139 ? 30.04751  1.45617   -13.99695 1.000 14.63542  ?  220 ASN A O    1 
ATOM   2192 C CB   . ASN A 1 139 ? 27.19486  0.63886   -13.19531 1.000 13.31715  ?  220 ASN A CB   1 
ATOM   2193 C CG   . ASN A 1 139 ? 25.78591  0.82487   -13.56738 1.000 14.20763  ?  220 ASN A CG   1 
ATOM   2194 O OD1  . ASN A 1 139 ? 25.42960  1.71334   -14.32019 1.000 16.00879  ?  220 ASN A OD1  1 
ATOM   2195 N ND2  . ASN A 1 139 ? 24.92158  -0.06726  -13.03030 1.000 17.08075  ?  220 ASN A ND2  1 
ATOM   2196 H H    A ASN A 1 139 ? 27.03955  -1.64253  -14.10472 0.930 14.78597  ?  220 ASN A H    1 
ATOM   2197 D D    B ASN A 1 139 ? 27.03943  -1.64035  -14.10327 0.070 14.78597  ?  220 ASN A D    1 
ATOM   2198 H HA   . ASN A 1 139 ? 27.86192  0.79129   -15.23877 1.000 15.33244  ?  220 ASN A HA   1 
ATOM   2199 H HB2  . ASN A 1 139 ? 27.23858  -0.10742  -12.40205 1.000 15.98058  ?  220 ASN A HB2  1 
ATOM   2200 H HB3  . ASN A 1 139 ? 27.57636  1.59278   -12.83118 1.000 15.98058  ?  220 ASN A HB3  1 
ATOM   2201 H HD21 A ASN A 1 139 ? 23.92579  -0.00346  -13.24180 0.090 20.49690  ?  220 ASN A HD21 1 
ATOM   2202 D DD21 B ASN A 1 139 ? 23.92579  -0.00346  -13.24180 0.910 20.49690  ?  220 ASN A DD21 1 
ATOM   2203 H HD22 A ASN A 1 139 ? 25.26590  -0.80347  -12.41399 0.070 20.49690  ?  220 ASN A HD22 1 
ATOM   2204 D DD22 B ASN A 1 139 ? 25.26590  -0.80347  -12.41399 0.930 20.49690  ?  220 ASN A DD22 1 
ATOM   2205 N N    . LEU A 1 140 ? 30.11609  -0.73058  -13.43787 1.000 13.15123  ?  221 LEU A N    1 
ATOM   2206 C CA   . LEU A 1 140 ? 31.49872  -0.63498  -13.03083 1.000 13.75249  ?  221 LEU A CA   1 
ATOM   2207 C C    . LEU A 1 140 ? 32.45061  -0.67099  -14.20703 1.000 17.05890  ?  221 LEU A C    1 
ATOM   2208 O O    . LEU A 1 140 ? 33.64608  -0.40547  -14.02445 1.000 22.57078  ?  221 LEU A O    1 
ATOM   2209 C CB   . LEU A 1 140 ? 31.82518  -1.71477  -12.01091 1.000 15.23674  ?  221 LEU A CB   1 
ATOM   2210 C CG   . LEU A 1 140 ? 30.85915  -1.77269  -10.83518 1.000 16.56594  ?  221 LEU A CG   1 
ATOM   2211 C CD1  . LEU A 1 140 ? 31.25096  -2.90972  -9.90205  1.000 20.71530  ?  221 LEU A CD1  1 
ATOM   2212 C CD2  . LEU A 1 140 ? 30.73144  -0.45766  -10.09776 1.000 19.60525  ?  221 LEU A CD2  1 
ATOM   2213 H H    A LEU A 1 140 ? 29.68665  -1.64504  -13.29735 0.900 15.78148  ?  221 LEU A H    1 
ATOM   2214 D D    B LEU A 1 140 ? 29.68683  -1.64511  -13.29727 0.100 15.78148  ?  221 LEU A D    1 
ATOM   2215 H HA   . LEU A 1 140 ? 31.66420  0.31516   -12.52294 1.000 16.50299  ?  221 LEU A HA   1 
ATOM   2216 H HB2  . LEU A 1 140 ? 31.79945  -2.68372  -12.50950 1.000 18.28409  ?  221 LEU A HB2  1 
ATOM   2217 H HB3  . LEU A 1 140 ? 32.82213  -1.52701  -11.61224 1.000 18.28409  ?  221 LEU A HB3  1 
ATOM   2218 H HG   . LEU A 1 140 ? 29.86160  -1.96950  -11.22795 1.000 19.87912  ?  221 LEU A HG   1 
ATOM   2219 H HD11 . LEU A 1 140 ? 32.23046  -2.69615  -9.47420  1.000 24.85836  ?  221 LEU A HD11 1 
ATOM   2220 H HD12 . LEU A 1 140 ? 30.50806  -2.98949  -9.10843  1.000 24.85836  ?  221 LEU A HD12 1 
ATOM   2221 H HD13 . LEU A 1 140 ? 31.28838  -3.83875  -10.47091 1.000 24.85836  ?  221 LEU A HD13 1 
ATOM   2222 H HD21 . LEU A 1 140 ? 30.45122  -0.65661  -9.06336  1.000 23.52630  ?  221 LEU A HD21 1 
ATOM   2223 H HD22 . LEU A 1 140 ? 31.68917  0.06179   -10.13009 1.000 23.52630  ?  221 LEU A HD22 1 
ATOM   2224 H HD23 . LEU A 1 140 ? 29.96409  0.14711   -10.58100 1.000 23.52630  ?  221 LEU A HD23 1 
ATOM   2225 N N    . VAL A 1 141 ? 31.96181  -0.93959  -15.41164 1.000 13.47086  ?  222 VAL A N    1 
ATOM   2226 C CA   . VAL A 1 141 ? 32.79817  -0.85959  -16.60188 1.000 16.54093  ?  222 VAL A CA   1 
ATOM   2227 C C    . VAL A 1 141 ? 32.76948  0.53399   -17.18924 1.000 15.98105  ?  222 VAL A C    1 
ATOM   2228 O O    . VAL A 1 141 ? 33.82077  1.09060   -17.50742 1.000 22.35851  ?  222 VAL A O    1 
ATOM   2229 C CB   . VAL A 1 141 ? 32.35272  -1.88632  -17.64754 1.000 16.00561  ?  222 VAL A CB   1 
ATOM   2230 C CG1  . VAL A 1 141 ? 33.25205  -1.77329  -18.86735 1.000 18.72834  ?  222 VAL A CG1  1 
ATOM   2231 C CG2  . VAL A 1 141 ? 32.41095  -3.26940  -17.04659 1.000 18.96143  ?  222 VAL A CG2  1 
ATOM   2232 H H    A VAL A 1 141 ? 30.99664  -1.21371  -15.59522 0.890 16.16503  ?  222 VAL A H    1 
ATOM   2233 D D    B VAL A 1 141 ? 30.99666  -1.21371  -15.59531 0.110 16.16503  ?  222 VAL A D    1 
ATOM   2234 H HA   . VAL A 1 141 ? 33.81979  -1.09966  -16.30733 1.000 19.84912  ?  222 VAL A HA   1 
ATOM   2235 H HB   . VAL A 1 141 ? 31.32584  -1.70035  -17.96223 1.000 19.20673  ?  222 VAL A HB   1 
ATOM   2236 H HG11 . VAL A 1 141 ? 33.96246  -0.96162  -18.71049 1.000 22.47400  ?  222 VAL A HG11 1 
ATOM   2237 H HG12 . VAL A 1 141 ? 33.78616  -2.71375  -19.00283 1.000 22.47400  ?  222 VAL A HG12 1 
ATOM   2238 H HG13 . VAL A 1 141 ? 32.63753  -1.56532  -19.74326 1.000 22.47400  ?  222 VAL A HG13 1 
ATOM   2239 H HG21 . VAL A 1 141 ? 31.70932  -3.91543  -17.57428 1.000 22.75371  ?  222 VAL A HG21 1 
ATOM   2240 H HG22 . VAL A 1 141 ? 33.42392  -3.65857  -17.14925 1.000 22.75371  ?  222 VAL A HG22 1 
ATOM   2241 H HG23 . VAL A 1 141 ? 32.14070  -3.20990  -15.99231 1.000 22.75371  ?  222 VAL A HG23 1 
ATOM   2242 N N    . THR A 1 142 ? 31.60924  1.14973   -17.33995 1.000 13.64546  ?  223 THR A N    1 
ATOM   2243 C CA   . THR A 1 142 ? 31.50832  2.42126   -18.06893 1.000 14.30963  ?  223 THR A CA   1 
ATOM   2244 C C    . THR A 1 142 ? 31.10188  3.62655   -17.24082 1.000 18.40287  ?  223 THR A C    1 
ATOM   2245 O O    . THR A 1 142 ? 31.15645  4.75160   -17.76253 1.000 18.85564  ?  223 THR A O    1 
ATOM   2246 C CB   . THR A 1 142 ? 30.48572  2.29092   -19.20838 1.000 16.18028  ?  223 THR A CB   1 
ATOM   2247 O OG1  . THR A 1 142 ? 29.17915  2.07521   -18.66124 1.000 16.94576  ?  223 THR A OG1  1 
ATOM   2248 C CG2  . THR A 1 142 ? 30.82003  1.11143   -20.13457 1.000 17.42878  ?  223 THR A CG2  1 
ATOM   2249 H H    A THR A 1 142 ? 30.72177  0.80380   -16.97508 0.120 16.37455  ?  223 THR A H    1 
ATOM   2250 D D    B THR A 1 142 ? 30.72225  0.80298   -16.97469 0.880 16.37455  ?  223 THR A D    1 
ATOM   2251 H HA   . THR A 1 142 ? 32.50079  2.62503   -18.47090 1.000 17.17156  ?  223 THR A HA   1 
ATOM   2252 H HB   . THR A 1 142 ? 30.50701  3.20860   -19.79618 1.000 19.41633  ?  223 THR A HB   1 
ATOM   2253 H HG1  A THR A 1 142 ? 28.77440  2.93226   -18.41213 0.160 20.33491  ?  223 THR A HG1  1 
ATOM   2254 D DG1  B THR A 1 142 ? 28.70687  2.92951   -18.57448 0.840 20.33491  ?  223 THR A DG1  1 
ATOM   2255 H HG21 . THR A 1 142 ? 31.86245  1.16747   -20.44813 1.000 20.91454  ?  223 THR A HG21 1 
ATOM   2256 H HG22 . THR A 1 142 ? 30.65821  0.16903   -19.61131 1.000 20.91454  ?  223 THR A HG22 1 
ATOM   2257 H HG23 . THR A 1 142 ? 30.18278  1.13923   -21.01845 1.000 20.91454  ?  223 THR A HG23 1 
ATOM   2258 N N    . ASN A 1 143 ? 30.63471  3.44917   -16.00198 1.000 14.26440  ?  224 ASN A N    1 
ATOM   2259 C CA   . ASN A 1 143 ? 30.00984  4.52623   -15.24411 1.000 14.00907  ?  224 ASN A CA   1 
ATOM   2260 C C    . ASN A 1 143 ? 30.75405  4.86414   -13.95220 1.000 13.32105  ?  224 ASN A C    1 
ATOM   2261 O O    . ASN A 1 143 ? 30.16418  5.36325   -13.00018 1.000 16.02687  ?  224 ASN A O    1 
ATOM   2262 C CB   . ASN A 1 143 ? 28.54777  4.21377   -14.94788 1.000 15.01306  ?  224 ASN A CB   1 
ATOM   2263 C CG   . ASN A 1 143 ? 27.66018  4.39160   -16.13804 1.000 22.57786  ?  224 ASN A CG   1 
ATOM   2264 O OD1  . ASN A 1 143 ? 27.93317  5.22209   -17.00605 1.000 26.95050  ?  224 ASN A OD1  1 
ATOM   2265 N ND2  . ASN A 1 143 ? 26.57569  3.62461   -16.20287 1.000 17.52547  ?  224 ASN A ND2  1 
ATOM   2266 H H    A ASN A 1 143 ? 30.67753  2.56323   -15.49831 0.120 17.11729  ?  224 ASN A H    1 
ATOM   2267 D D    B ASN A 1 143 ? 30.67844  2.56238   -15.49989 0.880 17.11729  ?  224 ASN A D    1 
ATOM   2268 H HA   . ASN A 1 143 ? 30.05080  5.41749   -15.87026 1.000 16.81089  ?  224 ASN A HA   1 
ATOM   2269 H HB2  . ASN A 1 143 ? 28.46639  3.17747   -14.61989 1.000 18.01567  ?  224 ASN A HB2  1 
ATOM   2270 H HB3  . ASN A 1 143 ? 28.19473  4.88217   -14.16258 1.000 18.01567  ?  224 ASN A HB3  1 
ATOM   2271 H HD21 A ASN A 1 143 ? 25.93854  3.70818   -16.99499 0.230 21.03057  ?  224 ASN A HD21 1 
ATOM   2272 D DD21 B ASN A 1 143 ? 25.93854  3.70818   -16.99499 0.770 21.03057  ?  224 ASN A DD21 1 
ATOM   2273 H HD22 A ASN A 1 143 ? 26.38106  2.95277   -15.46048 0.250 21.03057  ?  224 ASN A HD22 1 
ATOM   2274 D DD22 B ASN A 1 143 ? 26.38106  2.95277   -15.46048 0.750 21.03057  ?  224 ASN A DD22 1 
ATOM   2275 N N    . LEU A 1 144 ? 32.04681  4.61222   -13.90776 1.000 14.41471  ?  225 LEU A N    1 
ATOM   2276 C CA   . LEU A 1 144 ? 32.79455  4.93290   -12.70171 1.000 16.39981  ?  225 LEU A CA   1 
ATOM   2277 C C    . LEU A 1 144 ? 32.98745  6.41983   -12.46932 1.000 18.15815  ?  225 LEU A C    1 
ATOM   2278 O O    . LEU A 1 144 ? 33.41602  6.78459   -11.37762 1.000 20.66878  ?  225 LEU A O    1 
ATOM   2279 C CB   . LEU A 1 144 ? 34.15216  4.26879   -12.70395 1.000 19.31861  ?  225 LEU A CB   1 
ATOM   2280 C CG   . LEU A 1 144 ? 34.15618  2.76896   -12.47588 1.000 29.64993  ?  225 LEU A CG   1 
ATOM   2281 C CD1  . LEU A 1 144 ? 35.57965  2.24253   -12.45952 1.000 27.34492  ?  225 LEU A CD1  1 
ATOM   2282 C CD2  . LEU A 1 144 ? 33.40449  2.46157   -11.18797 1.000 25.01515  ?  225 LEU A CD2  1 
ATOM   2283 H H    A LEU A 1 144 ? 32.59312  4.19958   -14.66385 0.050 17.29765  ?  225 LEU A H    1 
ATOM   2284 D D    B LEU A 1 144 ? 32.59389  4.19963   -14.66331 0.950 17.29765  ?  225 LEU A D    1 
ATOM   2285 H HA   . LEU A 1 144 ? 32.21742  4.53132   -11.86879 1.000 19.67977  ?  225 LEU A HA   1 
ATOM   2286 H HB2  . LEU A 1 144 ? 34.61791  4.44973   -13.67268 1.000 23.18233  ?  225 LEU A HB2  1 
ATOM   2287 H HB3  . LEU A 1 144 ? 34.75194  4.71777   -11.91225 1.000 23.18233  ?  225 LEU A HB3  1 
ATOM   2288 H HG   . LEU A 1 144 ? 33.64726  2.25025   -13.28832 1.000 35.57992  ?  225 LEU A HG   1 
ATOM   2289 H HD11 . LEU A 1 144 ? 36.03589  2.42281   -13.43288 1.000 32.81390  ?  225 LEU A HD11 1 
ATOM   2290 H HD12 . LEU A 1 144 ? 36.14145  2.76262   -11.68363 1.000 32.81390  ?  225 LEU A HD12 1 
ATOM   2291 H HD13 . LEU A 1 144 ? 35.56008  1.17293   -12.25055 1.000 32.81390  ?  225 LEU A HD13 1 
ATOM   2292 H HD21 . LEU A 1 144 ? 33.73074  1.49297   -10.80920 1.000 30.01818  ?  225 LEU A HD21 1 
ATOM   2293 H HD22 . LEU A 1 144 ? 33.62190  3.23935   -10.45592 1.000 30.01818  ?  225 LEU A HD22 1 
ATOM   2294 H HD23 . LEU A 1 144 ? 32.33524  2.43748   -11.39826 1.000 30.01818  ?  225 LEU A HD23 1 
ATOM   2295 N N    . ASN A 1 145 ? 32.70446  7.27311   -13.44917 1.000 15.72561  ?  226 ASN A N    1 
ATOM   2296 C CA   . ASN A 1 145 ? 32.68403  8.71859   -13.22442 1.000 17.47841  ?  226 ASN A CA   1 
ATOM   2297 C C    . ASN A 1 145 ? 31.41068  9.20537   -12.56260 1.000 20.38554  ?  226 ASN A C    1 
ATOM   2298 O O    . ASN A 1 145 ? 31.34478  10.37858  -12.16819 1.000 22.99499  ?  226 ASN A O    1 
ATOM   2299 C CB   . ASN A 1 145 ? 32.85627  9.44890   -14.54736 1.000 19.95101  ?  226 ASN A CB   1 
ATOM   2300 C CG   . ASN A 1 145 ? 34.29063  9.43645   -15.01337 1.000 26.68314  ?  226 ASN A CG   1 
ATOM   2301 O OD1  . ASN A 1 145 ? 35.22068  9.63443   -14.20121 1.000 26.15153  ?  226 ASN A OD1  1 
ATOM   2302 N ND2  . ASN A 1 145 ? 34.48944  9.22924   -16.32211 1.000 32.43057  ?  226 ASN A ND2  1 
ATOM   2303 H H    A ASN A 1 145 ? 32.48557  6.99807   -14.40669 0.090 18.87073  ?  226 ASN A H    1 
ATOM   2304 D D    B ASN A 1 145 ? 32.48554  6.99828   -14.40675 0.910 18.87073  ?  226 ASN A D    1 
ATOM   2305 H HA   . ASN A 1 145 ? 33.51960  8.97252   -12.57215 1.000 20.97410  ?  226 ASN A HA   1 
ATOM   2306 H HB2  . ASN A 1 145 ? 32.24603  8.96225   -15.30820 1.000 23.94121  ?  226 ASN A HB2  1 
ATOM   2307 H HB3  . ASN A 1 145 ? 32.54533  10.48672  -14.42768 1.000 23.94121  ?  226 ASN A HB3  1 
ATOM   2308 N N    . VAL A 1 146 ? 30.40403  8.34548   -12.42635 1.000 14.67642  ?  227 VAL A N    1 
ATOM   2309 C CA   . VAL A 1 146 ? 29.23110  8.63439   -11.61756 1.000 15.96943  ?  227 VAL A CA   1 
ATOM   2310 C C    . VAL A 1 146 ? 29.61518  8.38514   -10.16652 1.000 16.39750  ?  227 VAL A C    1 
ATOM   2311 O O    . VAL A 1 146 ? 29.94231  7.25597   -9.78549  1.000 15.92747  ?  227 VAL A O    1 
ATOM   2312 C CB   . VAL A 1 146 ? 28.05813  7.74323   -12.01854 1.000 16.30722  ?  227 VAL A CB   1 
ATOM   2313 C CG1  . VAL A 1 146 ? 26.83197  8.05878   -11.18051 1.000 20.33445  ?  227 VAL A CG1  1 
ATOM   2314 C CG2  . VAL A 1 146 ? 27.76033  7.82583   -13.48593 1.000 18.64384  ?  227 VAL A CG2  1 
ATOM   2315 H H    A VAL A 1 146 ? 30.37447  7.42824   -12.87154 0.580 17.61171  ?  227 VAL A H    1 
ATOM   2316 D D    B VAL A 1 146 ? 30.37464  7.42827   -12.87162 0.420 17.61171  ?  227 VAL A D    1 
ATOM   2317 H HA   . VAL A 1 146 ? 28.93310  9.67469   -11.74824 1.000 19.16332  ?  227 VAL A HA   1 
ATOM   2318 H HB   . VAL A 1 146 ? 28.34090  6.70916   -11.82142 1.000 19.56866  ?  227 VAL A HB   1 
ATOM   2319 H HG11 . VAL A 1 146 ? 26.83187  7.42010   -10.29723 1.000 24.40134  ?  227 VAL A HG11 1 
ATOM   2320 H HG12 . VAL A 1 146 ? 26.86642  9.10644   -10.88165 1.000 24.40134  ?  227 VAL A HG12 1 
ATOM   2321 H HG13 . VAL A 1 146 ? 25.93789  7.87105   -11.77504 1.000 24.40134  ?  227 VAL A HG13 1 
ATOM   2322 H HG21 . VAL A 1 146 ? 26.68120  7.77915   -13.63221 1.000 22.37261  ?  227 VAL A HG21 1 
ATOM   2323 H HG22 . VAL A 1 146 ? 28.14765  8.76783   -13.87416 1.000 22.37261  ?  227 VAL A HG22 1 
ATOM   2324 H HG23 . VAL A 1 146 ? 28.24073  6.98916   -13.99318 1.000 22.37261  ?  227 VAL A HG23 1 
ATOM   2325 N N    . GLN A 1 147 ? 29.60840  9.43909   -9.34692  1.000 17.85411  ?  228 GLN A N    1 
ATOM   2326 C CA   . GLN A 1 147 ? 30.09250  9.28985   -7.98056  1.000 19.76861  ?  228 GLN A CA   1 
ATOM   2327 C C    . GLN A 1 147 ? 29.36339  8.17569   -7.22356  1.000 16.53075  ?  228 GLN A C    1 
ATOM   2328 O O    . GLN A 1 147 ? 29.98971  7.43373   -6.45912  1.000 17.29456  ?  228 GLN A O    1 
ATOM   2329 C CB   . GLN A 1 147 ? 29.94114  10.61808  -7.22746  1.000 26.40550  ?  228 GLN A CB   1 
ATOM   2330 C CG   . GLN A 1 147 ? 30.30847  10.53594  -5.73681  1.000 60.84999  ?  228 GLN A CG   1 
ATOM   2331 C CD   . GLN A 1 147 ? 30.42970  11.90129  -5.05360  1.000 102.71177 ?  228 GLN A CD   1 
ATOM   2332 O OE1  . GLN A 1 147 ? 30.91108  12.87426  -5.64475  1.000 88.01742  ?  228 GLN A OE1  1 
ATOM   2333 N NE2  . GLN A 1 147 ? 29.99851  11.96982  -3.79385  1.000 84.85737  ?  228 GLN A NE2  1 
ATOM   2334 H H    A GLN A 1 147 ? 29.28515  10.37480  -9.59260  0.000 21.42493  ?  228 GLN A H    1 
ATOM   2335 D D    B GLN A 1 147 ? 29.28573  10.37564  -9.59017  1.000 21.42493  ?  228 GLN A D    1 
ATOM   2336 H HA   . GLN A 1 147 ? 31.14847  9.02330   -8.02486  1.000 23.72234  ?  228 GLN A HA   1 
ATOM   2337 H HB2  . GLN A 1 147 ? 30.59409  11.35835  -7.68980  1.000 31.68660  ?  228 GLN A HB2  1 
ATOM   2338 H HB3  . GLN A 1 147 ? 28.90273  10.94230  -7.29594  1.000 31.68660  ?  228 GLN A HB3  1 
ATOM   2339 H HG2  . GLN A 1 147 ? 29.53519  9.97147   -5.21574  1.000 73.01999  ?  228 GLN A HG2  1 
ATOM   2340 H HG3  . GLN A 1 147 ? 31.26890  10.02971  -5.63975  1.000 73.01999  ?  228 GLN A HG3  1 
ATOM   2341 N N    . LYS A 1 148 ? 28.05205  8.06343   -7.38974  1.000 16.01463  ?  229 LYS A N    1 
ATOM   2342 C CA   . LYS A 1 148 ? 27.31958  7.01399   -6.67115  1.000 17.70285  ?  229 LYS A CA   1 
ATOM   2343 C C    . LYS A 1 148 ? 27.81354  5.61823   -7.04636  1.000 15.58935  ?  229 LYS A C    1 
ATOM   2344 O O    . LYS A 1 148 ? 27.86564  4.71333   -6.19743  1.000 15.98230  ?  229 LYS A O    1 
ATOM   2345 C CB   . LYS A 1 148 ? 25.82431  7.13400   -6.94864  1.000 18.08047  ?  229 LYS A CB   1 
ATOM   2346 C CG   . LYS A 1 148 ? 24.95437  6.25867   -6.05860  1.000 20.20181  ?  229 LYS A CG   1 
ATOM   2347 C CD   . LYS A 1 148 ? 23.47779  6.61794   -6.19096  1.000 23.18972  ?  229 LYS A CD   1 
ATOM   2348 C CE   . LYS A 1 148 ? 22.59258  5.67611   -5.37084  1.000 26.94529  ?  229 LYS A CE   1 
ATOM   2349 N NZ   . LYS A 1 148 ? 21.15305  5.92676   -5.57767  1.000 26.91864  ?  229 LYS A NZ   1 
ATOM   2350 H H    A LYS A 1 148 ? 27.48083  8.65743   -7.99081  0.000 19.21755  ?  229 LYS A H    1 
ATOM   2351 D D    B LYS A 1 148 ? 27.47869  8.65607   -7.99011  1.000 19.21755  ?  229 LYS A D    1 
ATOM   2352 H HA   . LYS A 1 148 ? 27.48594  7.15315   -5.60294  1.000 21.24342  ?  229 LYS A HA   1 
ATOM   2353 H HB2  . LYS A 1 148 ? 25.52240  8.16946   -6.79126  1.000 21.69656  ?  229 LYS A HB2  1 
ATOM   2354 H HB3  . LYS A 1 148 ? 25.63711  6.84413   -7.98258  1.000 21.69656  ?  229 LYS A HB3  1 
ATOM   2355 H HG2  . LYS A 1 148 ? 25.07979  5.21470   -6.34581  1.000 24.24218  ?  229 LYS A HG2  1 
ATOM   2356 H HG3  . LYS A 1 148 ? 25.24845  6.39701   -5.01818  1.000 24.24218  ?  229 LYS A HG3  1 
ATOM   2357 H HD2  . LYS A 1 148 ? 23.32048  7.63482   -5.83135  1.000 27.82767  ?  229 LYS A HD2  1 
ATOM   2358 H HD3  . LYS A 1 148 ? 23.18065  6.54227   -7.23695  1.000 27.82767  ?  229 LYS A HD3  1 
ATOM   2359 H HE2  . LYS A 1 148 ? 22.80132  4.64691   -5.66287  1.000 32.33435  ?  229 LYS A HE2  1 
ATOM   2360 H HE3  . LYS A 1 148 ? 22.81054  5.81466   -4.31187  1.000 32.33435  ?  229 LYS A HE3  1 
ATOM   2361 N N    . CYS A 1 149 ? 28.20462  5.42694   -8.30848  1.000 14.28737  ?  230 CYS A N    1 
ATOM   2362 C CA   . CYS A 1 149 ? 28.73793  4.13632   -8.73505  1.000 14.06683  ?  230 CYS A CA   1 
ATOM   2363 C C    . CYS A 1 149 ? 30.14211  3.91053   -8.19530  1.000 14.90918  ?  230 CYS A C    1 
ATOM   2364 O O    . CYS A 1 149 ? 30.47999  2.80226   -7.75837  1.000 14.62660  ?  230 CYS A O    1 
ATOM   2365 C CB   . CYS A 1 149 ? 28.75815  4.02445   -10.26812 1.000 14.84638  ?  230 CYS A CB   1 
ATOM   2366 S SG   . CYS A 1 149 ? 27.10481  4.02570   -11.03375 1.000 14.49873  ?  230 CYS A SG   1 
ATOM   2367 H H    A CYS A 1 149 ? 28.16536  6.13224   -9.04430  0.750 17.14484  ?  230 CYS A H    1 
ATOM   2368 D D    B CYS A 1 149 ? 28.16639  6.13048   -9.04603  0.250 17.14484  ?  230 CYS A D    1 
ATOM   2369 H HA   . CYS A 1 149 ? 28.07589  3.36287   -8.34572  1.000 16.88019  ?  230 CYS A HA   1 
ATOM   2370 H HB2  . CYS A 1 149 ? 29.31160  4.87185   -10.67273 1.000 17.81565  ?  230 CYS A HB2  1 
ATOM   2371 H HB3  . CYS A 1 149 ? 29.25048  3.09182   -10.54365 1.000 17.81565  ?  230 CYS A HB3  1 
ATOM   2372 N N    . ALA A 1 150 ? 30.99704  4.93207   -8.25439  1.000 14.51849  ?  231 ALA A N    1 
ATOM   2373 C CA   . ALA A 1 150 ? 32.34615  4.78359   -7.72646  1.000 16.22950  ?  231 ALA A CA   1 
ATOM   2374 C C    . ALA A 1 150 ? 32.30554  4.44811   -6.23942  1.000 15.46423  ?  231 ALA A C    1 
ATOM   2375 O O    . ALA A 1 150 ? 33.03555  3.57888   -5.76788  1.000 18.72668  ?  231 ALA A O    1 
ATOM   2376 C CB   . ALA A 1 150 ? 33.13650  6.07456   -7.97816  1.000 16.57832  ?  231 ALA A CB   1 
ATOM   2377 H H    A ALA A 1 150 ? 30.78973  5.84870   -8.65088  1.000 17.42219  ?  231 ALA A H    1 
ATOM   2378 D D    B ALA A 1 150 ? 30.79219  5.84951   -8.65030  0.000 17.42219  ?  231 ALA A D    1 
ATOM   2379 H HA   . ALA A 1 150 ? 32.85782  3.97007   -8.24073  1.000 19.47540  ?  231 ALA A HA   1 
ATOM   2380 H HB1  . ALA A 1 150 ? 33.88340  6.19217   -7.19305  1.000 19.89398  ?  231 ALA A HB1  1 
ATOM   2381 H HB2  . ALA A 1 150 ? 33.62595  6.00728   -8.94976  1.000 19.89398  ?  231 ALA A HB2  1 
ATOM   2382 H HB3  . ALA A 1 150 ? 32.44848  6.91989   -7.96630  1.000 19.89398  ?  231 ALA A HB3  1 
ATOM   2383 N N    . ASN A 1 151 ? 31.40670  5.07005   -5.50662  1.000 15.76649  ?  232 ASN A N    1 
ATOM   2384 C CA   . ASN A 1 151 ? 31.29752  4.79960   -4.07980  1.000 17.22884  ?  232 ASN A CA   1 
ATOM   2385 C C    . ASN A 1 151 ? 30.70332  3.42217   -3.82175  1.000 19.25716  ?  232 ASN A C    1 
ATOM   2386 O O    . ASN A 1 151 ? 30.91590  2.85551   -2.74372  1.000 22.35658  ?  232 ASN A O    1 
ATOM   2387 C CB   . ASN A 1 151 ? 30.38280  5.83434   -3.42345  1.000 22.50690  ?  232 ASN A CB   1 
ATOM   2388 C CG   . ASN A 1 151 ? 31.07201  7.16828   -3.19651  1.000 45.52792  ?  232 ASN A CG   1 
ATOM   2389 O OD1  . ASN A 1 151 ? 32.29791  7.25144   -3.22029  1.000 37.12756  ?  232 ASN A OD1  1 
ATOM   2390 N ND2  . ASN A 1 151 ? 30.27846  8.22544   -2.99039  1.000 38.55129  ?  232 ASN A ND2  1 
ATOM   2391 H H    A ASN A 1 151 ? 30.74317  5.76013   -5.85867  0.030 18.91979  ?  232 ASN A H    1 
ATOM   2392 D D    B ASN A 1 151 ? 30.74218  5.76040   -5.85625  0.970 18.91979  ?  232 ASN A D    1 
ATOM   2393 H HA   . ASN A 1 151 ? 32.29463  4.85937   -3.64359  1.000 20.67461  ?  232 ASN A HA   1 
ATOM   2394 H HB2  . ASN A 1 151 ? 29.52066  6.00584   -4.06797  1.000 27.00828  ?  232 ASN A HB2  1 
ATOM   2395 H HB3  . ASN A 1 151 ? 30.05507  5.45539   -2.45542  1.000 27.00828  ?  232 ASN A HB3  1 
ATOM   2396 N N    . ALA A 1 152 ? 29.90928  2.88852   -4.75174  1.000 15.30544  ?  233 ALA A N    1 
ATOM   2397 C CA   . ALA A 1 152 ? 29.24060  1.60873   -4.53835  1.000 14.96137  ?  233 ALA A CA   1 
ATOM   2398 C C    . ALA A 1 152 ? 30.07856  0.42672   -4.98739  1.000 15.74469  ?  233 ALA A C    1 
ATOM   2399 O O    . ALA A 1 152 ? 29.70430  -0.70634  -4.68868  1.000 16.54230  ?  233 ALA A O    1 
ATOM   2400 C CB   . ALA A 1 152 ? 27.92629  1.54564   -5.31437  1.000 17.20516  ?  233 ALA A CB   1 
ATOM   2401 H H    A ALA A 1 152 ? 29.71242  3.31753   -5.65595  0.070 18.36653  ?  233 ALA A H    1 
ATOM   2402 D D    B ALA A 1 152 ? 29.71281  3.31804   -5.65579  0.930 18.36653  ?  233 ALA A D    1 
ATOM   2403 H HA   . ALA A 1 152 ? 29.02594  1.52479   -3.47300  1.000 17.95365  ?  233 ALA A HA   1 
ATOM   2404 H HB1  . ALA A 1 152 ? 28.11826  1.13212   -6.30445  1.000 20.64620  ?  233 ALA A HB1  1 
ATOM   2405 H HB2  . ALA A 1 152 ? 27.22582  0.90825   -4.77476  1.000 20.64620  ?  233 ALA A HB2  1 
ATOM   2406 H HB3  . ALA A 1 152 ? 27.51884  2.55257   -5.40472  1.000 20.64620  ?  233 ALA A HB3  1 
ATOM   2407 N N    . LYS A 1 153 ? 31.18667  0.65929   -5.70327  1.000 15.07372  ?  234 LYS A N    1 
ATOM   2408 C CA   . LYS A 1 153 ? 31.92205  -0.41040  -6.35568  1.000 15.02527  ?  234 LYS A CA   1 
ATOM   2409 C C    . LYS A 1 153 ? 32.23828  -1.56209  -5.42025  1.000 15.75303  ?  234 LYS A C    1 
ATOM   2410 O O    . LYS A 1 153 ? 31.93672  -2.72198  -5.73654  1.000 15.93463  ?  234 LYS A O    1 
ATOM   2411 C CB   . LYS A 1 153 ? 33.20467  0.15204   -6.97028  1.000 16.90256  ?  234 LYS A CB   1 
ATOM   2412 C CG   . LYS A 1 153 ? 34.04674  -0.91308  -7.65261  1.000 19.18781  ?  234 LYS A CG   1 
ATOM   2413 C CD   . LYS A 1 153 ? 35.32317  -0.33064  -8.22614  1.000 30.40138  ?  234 LYS A CD   1 
ATOM   2414 C CE   . LYS A 1 153 ? 36.31309  -1.40508  -8.66357  1.000 40.82802  ?  234 LYS A CE   1 
ATOM   2415 N NZ   . LYS A 1 153 ? 37.28010  -0.85871  -9.67877  1.000 49.61581  ?  234 LYS A NZ   1 
ATOM   2416 H H    A LYS A 1 153 ? 31.59523  1.58296   -5.84582  0.250 18.08847  ?  234 LYS A H    1 
ATOM   2417 D D    B LYS A 1 153 ? 31.59687  1.58204   -5.84706  0.750 18.08847  ?  234 LYS A D    1 
ATOM   2418 H HA   . LYS A 1 153 ? 31.29453  -0.81386  -7.15037  1.000 18.03033  ?  234 LYS A HA   1 
ATOM   2419 H HB2  . LYS A 1 153 ? 32.94122  0.90254   -7.71556  1.000 20.28307  ?  234 LYS A HB2  1 
ATOM   2420 H HB3  . LYS A 1 153 ? 33.80666  0.60448   -6.18223  1.000 20.28307  ?  234 LYS A HB3  1 
ATOM   2421 H HG2  . LYS A 1 153 ? 34.31640  -1.67993  -6.92644  1.000 23.02537  ?  234 LYS A HG2  1 
ATOM   2422 H HG3  . LYS A 1 153 ? 33.47595  -1.35651  -8.46850  1.000 23.02537  ?  234 LYS A HG3  1 
ATOM   2423 H HD2  . LYS A 1 153 ? 35.07769  0.27663   -9.09738  1.000 36.48166  ?  234 LYS A HD2  1 
ATOM   2424 H HD3  . LYS A 1 153 ? 35.80659  0.28449   -7.46718  1.000 36.48166  ?  234 LYS A HD3  1 
ATOM   2425 H HE2  . LYS A 1 153 ? 36.87854  -1.75265  -7.79895  1.000 48.99363  ?  234 LYS A HE2  1 
ATOM   2426 H HE3  . LYS A 1 153 ? 35.77171  -2.23705  -9.11394  1.000 48.99363  ?  234 LYS A HE3  1 
ATOM   2427 N N    . THR A 1 154 ? 32.89823  -1.28810  -4.28309  1.000 15.64194  ?  235 THR A N    1 
ATOM   2428 C CA   A THR A 1 154 ? 33.30381  -2.40836  -3.44069  0.590 15.74278  ?  235 THR A CA   1 
ATOM   2429 C CA   B THR A 1 154 ? 33.30444  -2.35986  -3.37745  0.410 16.10852  ?  235 THR A CA   1 
ATOM   2430 C C    . THR A 1 154 ? 32.09918  -3.13090  -2.85552  1.000 15.56210  ?  235 THR A C    1 
ATOM   2431 O O    . THR A 1 154 ? 32.14025  -4.35613  -2.71201  1.000 15.58573  ?  235 THR A O    1 
ATOM   2432 C CB   A THR A 1 154 ? 34.26094  -1.95367  -2.32510  0.590 21.03498  ?  235 THR A CB   1 
ATOM   2433 C CB   B THR A 1 154 ? 34.08395  -1.76568  -2.19441  0.410 19.54950  ?  235 THR A CB   1 
ATOM   2434 O OG1  A THR A 1 154 ? 33.64680  -0.89623  -1.58160  0.590 20.76112  ?  235 THR A OG1  1 
ATOM   2435 O OG1  B THR A 1 154 ? 35.14254  -0.92916  -2.67650  0.410 22.37113  ?  235 THR A OG1  1 
ATOM   2436 C CG2  A THR A 1 154 ? 35.59761  -1.51124  -2.91195  0.590 18.38205  ?  235 THR A CG2  1 
ATOM   2437 C CG2  B THR A 1 154 ? 34.67500  -2.86943  -1.32661  0.410 18.65898  ?  235 THR A CG2  1 
ATOM   2438 H H    A THR A 1 154 ? 33.14788  -0.35875  -3.94489  0.000 18.77033  ?  235 THR A H    1 
ATOM   2439 D D    B THR A 1 154 ? 33.15961  -0.35327  -3.96975  1.000 18.77033  ?  235 THR A D    1 
ATOM   2440 H HA   A THR A 1 154 ? 33.85739  -3.11410  -4.06004  0.590 18.89134  ?  235 THR A HA   1 
ATOM   2441 H HA   B THR A 1 154 ? 33.94911  -3.05071  -3.92078  0.410 19.33022  ?  235 THR A HA   1 
ATOM   2442 H HB   A THR A 1 154 ? 34.47080  -2.77915  -1.64491  0.590 25.24198  ?  235 THR A HB   1 
ATOM   2443 H HB   B THR A 1 154 ? 33.40318  -1.17319  -1.58319  0.410 23.45940  ?  235 THR A HB   1 
ATOM   2444 H HG1  A THR A 1 154 ? 34.09793  -0.04719  -1.77133  0.590 24.91335  ?  235 THR A HG1  1 
ATOM   2445 H HG1  B THR A 1 154 ? 34.83459  -0.41051  -3.44888  0.410 26.84536  ?  235 THR A HG1  1 
ATOM   2446 H HG21 A THR A 1 154 ? 36.05886  -0.76357  -2.26671  0.590 22.05846  ?  235 THR A HG21 1 
ATOM   2447 H HG21 B THR A 1 154 ? 34.88347  -3.75004  -1.93420  0.410 22.39078  ?  235 THR A HG21 1 
ATOM   2448 H HG22 A THR A 1 154 ? 36.26818  -2.36622  -2.99818  0.590 22.05846  ?  235 THR A HG22 1 
ATOM   2449 H HG22 B THR A 1 154 ? 35.60342  -2.52729  -0.86935  0.410 22.39078  ?  235 THR A HG22 1 
ATOM   2450 H HG23 A THR A 1 154 ? 35.44581  -1.07954  -3.90124  0.590 22.05846  ?  235 THR A HG23 1 
ATOM   2451 H HG23 B THR A 1 154 ? 33.97206  -3.14128  -0.53917  0.410 22.39078  ?  235 THR A HG23 1 
ATOM   2452 N N    . THR A 1 155 ? 31.01496  -2.42185  -2.54620  1.000 13.51656  ?  236 THR A N    1 
ATOM   2453 C CA   . THR A 1 155 ? 29.81416  -3.06342  -2.04486  1.000 13.84090  ?  236 THR A CA   1 
ATOM   2454 C C    . THR A 1 155 ? 29.14909  -3.92582  -3.11734  1.000 13.61821  ?  236 THR A C    1 
ATOM   2455 O O    . THR A 1 155 ? 28.71132  -5.04375  -2.82914  1.000 14.06469  ?  236 THR A O    1 
ATOM   2456 C CB   . THR A 1 155 ? 28.83137  -2.01671  -1.53671  1.000 15.02952  ?  236 THR A CB   1 
ATOM   2457 O OG1  . THR A 1 155 ? 29.41779  -1.27317  -0.46292  1.000 18.79607  ?  236 THR A OG1  1 
ATOM   2458 C CG2  . THR A 1 155 ? 27.55348  -2.65519  -1.01780  1.000 17.80765  ?  236 THR A CG2  1 
ATOM   2459 H H    A THR A 1 155 ? 30.94115  -1.40820  -2.63255  0.070 16.21988  ?  236 THR A H    1 
ATOM   2460 D D    B THR A 1 155 ? 30.93861  -1.40831  -2.63163  0.930 16.21988  ?  236 THR A D    1 
ATOM   2461 H HA   . THR A 1 155 ? 30.09386  -3.70800  -1.21156  1.000 16.60907  ?  236 THR A HA   1 
ATOM   2462 H HB   . THR A 1 155 ? 28.58317  -1.35663  -2.36785  1.000 18.03542  ?  236 THR A HB   1 
ATOM   2463 H HG1  C THR A 1 155 ? 29.83569  -0.45719  -0.80925  0.160 22.55528  ?  236 THR A HG1  1 
ATOM   2464 D DG1  D THR A 1 155 ? 29.81774  -0.44708  -0.80645  0.840 22.55528  ?  236 THR A DG1  1 
ATOM   2465 H HG21 . THR A 1 155 ? 27.72492  -3.08292  -0.03000  1.000 21.36918  ?  236 THR A HG21 1 
ATOM   2466 H HG22 . THR A 1 155 ? 26.76468  -1.90628  -0.94695  1.000 21.36918  ?  236 THR A HG22 1 
ATOM   2467 H HG23 . THR A 1 155 ? 27.23049  -3.44621  -1.69461  1.000 21.36918  ?  236 THR A HG23 1 
ATOM   2468 N N    . TYR A 1 156 ? 29.00123  -3.41317  -4.33851  1.000 12.07756  ?  237 TYR A N    1 
ATOM   2469 C CA   . TYR A 1 156 ? 28.44409  -4.22744  -5.41231  1.000 11.17580  ?  237 TYR A CA   1 
ATOM   2470 C C    . TYR A 1 156 ? 29.23807  -5.52683  -5.57218  1.000 12.37051  ?  237 TYR A C    1 
ATOM   2471 O O    . TYR A 1 156 ? 28.65459  -6.60069  -5.68457  1.000 12.37492  ?  237 TYR A O    1 
ATOM   2472 C CB   . TYR A 1 156 ? 28.46834  -3.47101  -6.73059  1.000 13.05330  ?  237 TYR A CB   1 
ATOM   2473 C CG   . TYR A 1 156 ? 27.36072  -2.47823  -7.00206  1.000 11.48302  ?  237 TYR A CG   1 
ATOM   2474 C CD1  . TYR A 1 156 ? 26.48129  -2.01512  -6.02944  1.000 12.25003  ?  237 TYR A CD1  1 
ATOM   2475 C CD2  . TYR A 1 156 ? 27.18767  -2.02602  -8.30857  1.000 12.37290  ?  237 TYR A CD2  1 
ATOM   2476 C CE1  . TYR A 1 156 ? 25.50397  -1.08202  -6.34497  1.000 12.31647  ?  237 TYR A CE1  1 
ATOM   2477 C CE2  . TYR A 1 156 ? 26.20758  -1.10985  -8.65229  1.000 13.37347  ?  237 TYR A CE2  1 
ATOM   2478 C CZ   . TYR A 1 156 ? 25.36535  -0.63915  -7.64969  1.000 12.60994  ?  237 TYR A CZ   1 
ATOM   2479 O OH   . TYR A 1 156 ? 24.35743  0.26658   -7.98548  1.000 13.78653  ?  237 TYR A OH   1 
ATOM   2480 H H    A TYR A 1 156 ? 29.25140  -2.46192  -4.60860  0.980 14.49307  ?  237 TYR A H    1 
ATOM   2481 D D    B TYR A 1 156 ? 29.25067  -2.46236  -4.61080  0.020 14.49307  ?  237 TYR A D    1 
ATOM   2482 H HA   . TYR A 1 156 ? 27.40854  -4.45482  -5.15929  1.000 13.41096  ?  237 TYR A HA   1 
ATOM   2483 H HB2  . TYR A 1 156 ? 29.40418  -2.91401  -6.77593  1.000 15.66396  ?  237 TYR A HB2  1 
ATOM   2484 H HB3  . TYR A 1 156 ? 28.43244  -4.20570  -7.53498  1.000 15.66396  ?  237 TYR A HB3  1 
ATOM   2485 H HD1  . TYR A 1 156 ? 26.55979  -2.38556  -5.01800  1.000 14.70003  ?  237 TYR A HD1  1 
ATOM   2486 H HD2  . TYR A 1 156 ? 27.84131  -2.40353  -9.08099  1.000 14.84748  ?  237 TYR A HD2  1 
ATOM   2487 H HE1  . TYR A 1 156 ? 24.85153  -0.70123  -5.57315  1.000 14.77977  ?  237 TYR A HE1  1 
ATOM   2488 H HE2  . TYR A 1 156 ? 26.09985  -0.76972  -9.67166  1.000 16.04816  ?  237 TYR A HE2  1 
ATOM   2489 H HH   A TYR A 1 156 ? 24.08609  0.77510   -7.19290  0.080 16.54383  ?  237 TYR A HH   1 
ATOM   2490 D DH   B TYR A 1 156 ? 24.07706  0.76602   -7.19028  0.920 16.54383  ?  237 TYR A DH   1 
ATOM   2491 N N    . LEU A 1 157 ? 30.57642  -5.43896  -5.59067  1.000 11.81601  ?  238 LEU A N    1 
ATOM   2492 C CA   . LEU A 1 157 ? 31.39570  -6.62772  -5.77480  1.000 12.88243  ?  238 LEU A CA   1 
ATOM   2493 C C    . LEU A 1 157 ? 31.22823  -7.58261  -4.59672  1.000 12.52326  ?  238 LEU A C    1 
ATOM   2494 O O    . LEU A 1 157 ? 31.08257  -8.78762  -4.79888  1.000 13.07668  ?  238 LEU A O    1 
ATOM   2495 C CB   . LEU A 1 157 ? 32.86871  -6.28277  -5.95298  1.000 15.31869  ?  238 LEU A CB   1 
ATOM   2496 C CG   . LEU A 1 157 ? 33.14594  -5.53324  -7.25813  1.000 17.36000  ?  238 LEU A CG   1 
ATOM   2497 C CD1  . LEU A 1 157 ? 34.57299  -5.01035  -7.24714  1.000 21.25189  ?  238 LEU A CD1  1 
ATOM   2498 C CD2  . LEU A 1 157 ? 32.95099  -6.38915  -8.47315  1.000 19.25702  ?  238 LEU A CD2  1 
ATOM   2499 H H    A LEU A 1 157 ? 31.10542  -4.57359  -5.48246  0.910 14.17921  ?  238 LEU A H    1 
ATOM   2500 D D    B LEU A 1 157 ? 31.10770  -4.57496  -5.48270  0.090 14.17921  ?  238 LEU A D    1 
ATOM   2501 H HA   . LEU A 1 157 ? 31.06878  -7.11526  -6.69324  1.000 15.45891  ?  238 LEU A HA   1 
ATOM   2502 H HB2  . LEU A 1 157 ? 33.18699  -5.64962  -5.12478  1.000 18.38243  ?  238 LEU A HB2  1 
ATOM   2503 H HB3  . LEU A 1 157 ? 33.44992  -7.20484  -5.96208  1.000 18.38243  ?  238 LEU A HB3  1 
ATOM   2504 H HG   . LEU A 1 157 ? 32.43313  -4.71128  -7.32437  1.000 20.83200  ?  238 LEU A HG   1 
ATOM   2505 H HD11 . LEU A 1 157 ? 35.25839  -5.84649  -7.38568  1.000 25.50227  ?  238 LEU A HD11 1 
ATOM   2506 H HD12 . LEU A 1 157 ? 34.69405  -4.29220  -8.05814  1.000 25.50227  ?  238 LEU A HD12 1 
ATOM   2507 H HD13 . LEU A 1 157 ? 34.76613  -4.52608  -6.28991  1.000 25.50227  ?  238 LEU A HD13 1 
ATOM   2508 H HD21 . LEU A 1 157 ? 33.04183  -5.76718  -9.36366  1.000 23.10842  ?  238 LEU A HD21 1 
ATOM   2509 H HD22 . LEU A 1 157 ? 33.71332  -7.16814  -8.48450  1.000 23.10842  ?  238 LEU A HD22 1 
ATOM   2510 H HD23 . LEU A 1 157 ? 31.95938  -6.84002  -8.43423  1.000 23.10842  ?  238 LEU A HD23 1 
ATOM   2511 N N    . ALA A 1 158 ? 31.23716  -7.06490  -3.36286  1.000 12.09562  ?  239 ALA A N    1 
ATOM   2512 C CA   . ALA A 1 158 ? 31.12294  -7.94465  -2.20771  1.000 12.18110  ?  239 ALA A CA   1 
ATOM   2513 C C    . ALA A 1 158 ? 29.75154  -8.60189  -2.13642  1.000 11.51259  ?  239 ALA A C    1 
ATOM   2514 O O    . ALA A 1 158 ? 29.62012  -9.77037  -1.78125  1.000 12.45929  ?  239 ALA A O    1 
ATOM   2515 C CB   . ALA A 1 158 ? 31.36533  -7.16489  -0.92345  1.000 14.80896  ?  239 ALA A CB   1 
ATOM   2516 H H    A ALA A 1 158 ? 31.31960  -6.07245  -3.14230  0.750 14.51474  ?  239 ALA A H    1 
ATOM   2517 D D    B ALA A 1 158 ? 31.31947  -6.07301  -3.13974  0.250 14.51474  ?  239 ALA A D    1 
ATOM   2518 H HA   . ALA A 1 158 ? 31.88299  -8.72009  -2.30311  1.000 14.61732  ?  239 ALA A HA   1 
ATOM   2519 H HB1  . ALA A 1 158 ? 31.29223  -7.84599  -0.07559  1.000 17.77075  ?  239 ALA A HB1  1 
ATOM   2520 H HB2  . ALA A 1 158 ? 32.36063  -6.72199  -0.95969  1.000 17.77075  ?  239 ALA A HB2  1 
ATOM   2521 H HB3  . ALA A 1 158 ? 30.61270  -6.38124  -0.83667  1.000 17.77075  ?  239 ALA A HB3  1 
ATOM   2522 N N    . CYS A 1 159 ? 28.68509  -7.84710  -2.44444  1.000 11.49105  ?  240 CYS A N    1 
ATOM   2523 C CA   . CYS A 1 159 ? 27.33921  -8.40903  -2.43202  1.000 11.65416  ?  240 CYS A CA   1 
ATOM   2524 C C    . CYS A 1 159 ? 27.12171  -9.44440  -3.52720  1.000 10.44681  ?  240 CYS A C    1 
ATOM   2525 O O    . CYS A 1 159 ? 26.54929  -10.51204 -3.27624  1.000 11.87326  ?  240 CYS A O    1 
ATOM   2526 C CB   . CYS A 1 159 ? 26.32461  -7.29407  -2.55681  1.000 11.54134  ?  240 CYS A CB   1 
ATOM   2527 S SG   . CYS A 1 159 ? 26.13367  -6.32435  -1.05328  1.000 14.53301  ?  240 CYS A SG   1 
ATOM   2528 H H    A CYS A 1 159 ? 28.72577  -6.86087  -2.70154  1.000 13.78926  ?  240 CYS A H    1 
ATOM   2529 D D    B CYS A 1 159 ? 28.72309  -6.86084  -2.70182  0.000 13.78926  ?  240 CYS A D    1 
ATOM   2530 H HA   . CYS A 1 159 ? 27.19660  -8.91862  -1.47909  1.000 13.98499  ?  240 CYS A HA   1 
ATOM   2531 H HB2  . CYS A 1 159 ? 26.64094  -6.61874  -3.35177  1.000 13.84960  ?  240 CYS A HB2  1 
ATOM   2532 H HB3  . CYS A 1 159 ? 25.35454  -7.72760  -2.79995  1.000 13.84960  ?  240 CYS A HB3  1 
ATOM   2533 H HG   A CYS A 1 159 ? 27.12772  -5.49209  -0.95733  0.340 17.43961  ?  240 CYS A HG   1 
ATOM   2534 D DG   B CYS A 1 159 ? 27.11187  -5.47196  -0.97232  0.660 17.43961  ?  240 CYS A DG   1 
ATOM   2535 N N    . VAL A 1 160 ? 27.59823  -9.16182  -4.74228  1.000 11.17977  ?  241 VAL A N    1 
ATOM   2536 C CA   . VAL A 1 160 ? 27.48067  -10.15917 -5.80258  1.000 12.05958  ?  241 VAL A CA   1 
ATOM   2537 C C    . VAL A 1 160 ? 28.25876  -11.40962 -5.42635  1.000 11.63849  ?  241 VAL A C    1 
ATOM   2538 O O    . VAL A 1 160 ? 27.79114  -12.53141 -5.61761  1.000 12.13668  ?  241 VAL A O    1 
ATOM   2539 C CB   . VAL A 1 160 ? 27.89207  -9.58450  -7.16963  1.000 11.27924  ?  241 VAL A CB   1 
ATOM   2540 C CG1  . VAL A 1 160 ? 28.00698  -10.67564 -8.20502  1.000 14.59380  ?  241 VAL A CG1  1 
ATOM   2541 C CG2  . VAL A 1 160 ? 26.87427  -8.55243  -7.59502  1.000 14.01158  ?  241 VAL A CG2  1 
ATOM   2542 H H    A VAL A 1 160 ? 28.05138  -8.28854  -5.01141  0.910 13.41572  ?  241 VAL A H    1 
ATOM   2543 D D    B VAL A 1 160 ? 28.05166  -8.28933  -5.01352  0.090 13.41572  ?  241 VAL A D    1 
ATOM   2544 H HA   . VAL A 1 160 ? 26.43115  -10.43691 -5.89983  1.000 14.47150  ?  241 VAL A HA   1 
ATOM   2545 H HB   . VAL A 1 160 ? 28.87185  -9.11417  -7.08647  1.000 13.53509  ?  241 VAL A HB   1 
ATOM   2546 H HG11 . VAL A 1 160 ? 29.00115  -10.63891 -8.65043  1.000 17.51256  ?  241 VAL A HG11 1 
ATOM   2547 H HG12 . VAL A 1 160 ? 27.85128  -11.64054 -7.72250  1.000 17.51256  ?  241 VAL A HG12 1 
ATOM   2548 H HG13 . VAL A 1 160 ? 27.24962  -10.51748 -8.97280  1.000 17.51256  ?  241 VAL A HG13 1 
ATOM   2549 H HG21 . VAL A 1 160 ? 27.11978  -8.20447  -8.59839  1.000 16.81390  ?  241 VAL A HG21 1 
ATOM   2550 H HG22 . VAL A 1 160 ? 25.88408  -9.00806  -7.59152  1.000 16.81390  ?  241 VAL A HG22 1 
ATOM   2551 H HG23 . VAL A 1 160 ? 26.90169  -7.71742  -6.89494  1.000 16.81390  ?  241 VAL A HG23 1 
ATOM   2552 N N    . ASN A 1 161 ? 29.45665  -11.24369 -4.85968  1.000 11.95663  ?  242 ASN A N    1 
ATOM   2553 C CA   . ASN A 1 161 ? 30.21466  -12.40387 -4.42542  1.000 10.73796  ?  242 ASN A CA   1 
ATOM   2554 C C    . ASN A 1 161 ? 29.44058  -13.22251 -3.40741  1.000 12.39431  ?  242 ASN A C    1 
ATOM   2555 O O    . ASN A 1 161 ? 29.45007  -14.45978 -3.45823  1.000 12.65892  ?  242 ASN A O    1 
ATOM   2556 C CB   . ASN A 1 161 ? 31.53614  -11.94910 -3.82052  1.000 13.78324  ?  242 ASN A CB   1 
ATOM   2557 C CG   . ASN A 1 161 ? 32.42890  -13.09436 -3.46019  1.000 15.41924  ?  242 ASN A CG   1 
ATOM   2558 O OD1  . ASN A 1 161 ? 32.88051  -13.84812 -4.33322  1.000 16.06417  ?  242 ASN A OD1  1 
ATOM   2559 N ND2  . ASN A 1 161 ? 32.69831  -13.25811 -2.16844  1.000 19.32192  ?  242 ASN A ND2  1 
ATOM   2560 H H    A ASN A 1 161 ? 29.91033  -10.34510 -4.69505  1.000 14.34796  ?  242 ASN A H    1 
ATOM   2561 D D    B ASN A 1 161 ? 29.91241  -10.34635 -4.69398  0.000 14.34796  ?  242 ASN A D    1 
ATOM   2562 H HA   . ASN A 1 161 ? 30.41615  -13.03537 -5.29070  1.000 12.88555  ?  242 ASN A HA   1 
ATOM   2563 H HB2  . ASN A 1 161 ? 32.06220  -11.32532 -4.54319  1.000 16.53989  ?  242 ASN A HB2  1 
ATOM   2564 H HB3  . ASN A 1 161 ? 31.33476  -11.37957 -2.91322  1.000 16.53989  ?  242 ASN A HB3  1 
ATOM   2565 H HD21 A ASN A 1 161 ? 33.30162  -14.02304 -1.86626  0.170 23.18631  ?  242 ASN A HD21 1 
ATOM   2566 D DD21 B ASN A 1 161 ? 33.30162  -14.02304 -1.86626  0.830 23.18631  ?  242 ASN A DD21 1 
ATOM   2567 H HD22 A ASN A 1 161 ? 32.30166  -12.61881 -1.47970  0.280 23.18631  ?  242 ASN A HD22 1 
ATOM   2568 D DD22 B ASN A 1 161 ? 32.30166  -12.61881 -1.47970  0.720 23.18631  ?  242 ASN A DD22 1 
ATOM   2569 N N    . TYR A 1 162 ? 28.78204  -12.55567 -2.44598  1.000 11.28437  ?  243 TYR A N    1 
ATOM   2570 C CA   . TYR A 1 162 ? 28.03360  -13.29456 -1.42733  1.000 11.05461  ?  243 TYR A CA   1 
ATOM   2571 C C    . TYR A 1 162 ? 26.90202  -14.08394 -2.04826  1.000 11.16133  ?  243 TYR A C    1 
ATOM   2572 O O    . TYR A 1 162 ? 26.64184  -15.24384 -1.68243  1.000 12.59817  ?  243 TYR A O    1 
ATOM   2573 C CB   . TYR A 1 162 ? 27.49965  -12.31264 -0.39851  1.000 11.99478  ?  243 TYR A CB   1 
ATOM   2574 C CG   . TYR A 1 162 ? 26.92464  -12.96880 0.82304   1.000 12.76403  ?  243 TYR A CG   1 
ATOM   2575 C CD1  . TYR A 1 162 ? 27.75289  -13.27780 1.90903   1.000 14.51696  ?  243 TYR A CD1  1 
ATOM   2576 C CD2  . TYR A 1 162 ? 25.60217  -13.31997 0.90280   1.000 13.53448  ?  243 TYR A CD2  1 
ATOM   2577 C CE1  . TYR A 1 162 ? 27.25104  -13.88414 3.04089   1.000 14.87210  ?  243 TYR A CE1  1 
ATOM   2578 C CE2  . TYR A 1 162 ? 25.07734  -13.93028 2.02887   1.000 15.29331  ?  243 TYR A CE2  1 
ATOM   2579 C CZ   . TYR A 1 162 ? 25.93410  -14.21401 3.10162   1.000 14.16486  ?  243 TYR A CZ   1 
ATOM   2580 O OH   . TYR A 1 162 ? 25.43492  -14.83027 4.23117   1.000 16.98814  ?  243 TYR A OH   1 
ATOM   2581 H H    A TYR A 1 162 ? 28.75047  -11.54057 -2.35125  0.970 13.54125  ?  243 TYR A H    1 
ATOM   2582 D D    B TYR A 1 162 ? 28.74894  -11.54082 -2.34910  0.030 13.54125  ?  243 TYR A D    1 
ATOM   2583 H HA   . TYR A 1 162 ? 28.69532  -14.00140 -0.92673  1.000 13.26553  ?  243 TYR A HA   1 
ATOM   2584 H HB2  . TYR A 1 162 ? 28.31513  -11.66541 -0.07571  1.000 14.39374  ?  243 TYR A HB2  1 
ATOM   2585 H HB3  . TYR A 1 162 ? 26.71102  -11.71732 -0.85869  1.000 14.39374  ?  243 TYR A HB3  1 
ATOM   2586 H HD1  . TYR A 1 162 ? 28.80442  -13.03661 1.85899   1.000 17.42035  ?  243 TYR A HD1  1 
ATOM   2587 H HD2  . TYR A 1 162 ? 24.95239  -13.11507 0.06482   1.000 16.24138  ?  243 TYR A HD2  1 
ATOM   2588 H HE1  . TYR A 1 162 ? 27.90203  -14.09618 3.87615   1.000 17.84652  ?  243 TYR A HE1  1 
ATOM   2589 H HE2  . TYR A 1 162 ? 24.02854  -14.18288 2.08005   1.000 18.35198  ?  243 TYR A HE2  1 
ATOM   2590 H HH   A TYR A 1 162 ? 24.46645  -14.95329 4.14561   0.000 20.38576  ?  243 TYR A HH   1 
ATOM   2591 D DH   B TYR A 1 162 ? 24.52499  -15.15279 4.06264   1.000 20.38576  ?  243 TYR A DH   1 
ATOM   2592 N N    . ALA A 1 163 ? 26.21751  -13.46386 -3.00875  1.000 11.19364  ?  244 ALA A N    1 
ATOM   2593 C CA   . ALA A 1 163 ? 25.13665  -14.14951 -3.69293  1.000 11.49989  ?  244 ALA A CA   1 
ATOM   2594 C C    . ALA A 1 163 ? 25.64915  -15.35993 -4.44311  1.000 10.91718  ?  244 ALA A C    1 
ATOM   2595 O O    . ALA A 1 163 ? 25.08256  -16.44656 -4.33758  1.000 12.18108  ?  244 ALA A O    1 
ATOM   2596 C CB   . ALA A 1 163 ? 24.42499  -13.17609 -4.62127  1.000 12.63656  ?  244 ALA A CB   1 
ATOM   2597 H H    A ALA A 1 163 ? 26.38670  -12.50913 -3.32540  0.900 13.43237  ?  244 ALA A H    1 
ATOM   2598 D D    B ALA A 1 163 ? 26.38495  -12.50934 -3.32697  0.100 13.43237  ?  244 ALA A D    1 
ATOM   2599 H HA   . ALA A 1 163 ? 24.41054  -14.50479 -2.96173  1.000 13.79987  ?  244 ALA A HA   1 
ATOM   2600 H HB1  . ALA A 1 163 ? 25.11207  -12.87213 -5.41098  1.000 15.16387  ?  244 ALA A HB1  1 
ATOM   2601 H HB2  . ALA A 1 163 ? 23.55564  -13.67038 -5.05485  1.000 15.16387  ?  244 ALA A HB2  1 
ATOM   2602 H HB3  . ALA A 1 163 ? 24.10941  -12.30476 -4.04742  1.000 15.16387  ?  244 ALA A HB3  1 
ATOM   2603 N N    . LEU A 1 164 ? 26.71565  -15.18684 -5.23961  1.000 10.43548  ?  245 LEU A N    1 
ATOM   2604 C CA   . LEU A 1 164 ? 27.20754  -16.29089 -6.05459  1.000 10.91400  ?  245 LEU A CA   1 
ATOM   2605 C C    . LEU A 1 164 ? 27.67549  -17.44385 -5.17730  1.000 11.57175  ?  245 LEU A C    1 
ATOM   2606 O O    . LEU A 1 164 ? 27.36665  -18.61338 -5.44813  1.000 13.59355  ?  245 LEU A O    1 
ATOM   2607 C CB   . LEU A 1 164 ? 28.37417  -15.83285 -6.91562  1.000 11.45585  ?  245 LEU A CB   1 
ATOM   2608 C CG   . LEU A 1 164 ? 28.06504  -14.79627 -7.97132  1.000 12.28481  ?  245 LEU A CG   1 
ATOM   2609 C CD1  . LEU A 1 164 ? 29.35350  -14.38292 -8.65963  1.000 15.90559  ?  245 LEU A CD1  1 
ATOM   2610 C CD2  . LEU A 1 164 ? 27.08748  -15.28539 -9.00536  1.000 16.88694  ?  245 LEU A CD2  1 
ATOM   2611 H H    A LEU A 1 164 ? 27.24049  -14.31745 -5.33506  0.960 12.52258  ?  245 LEU A H    1 
ATOM   2612 D D    B LEU A 1 164 ? 27.24192  -14.31849 -5.33661  0.040 12.52258  ?  245 LEU A D    1 
ATOM   2613 H HA   . LEU A 1 164 ? 26.39420  -16.62388 -6.69934  1.000 13.09680  ?  245 LEU A HA   1 
ATOM   2614 H HB2  . LEU A 1 164 ? 29.13162  -15.40537 -6.25863  1.000 13.74701  ?  245 LEU A HB2  1 
ATOM   2615 H HB3  . LEU A 1 164 ? 28.77675  -16.70499 -7.43080  1.000 13.74701  ?  245 LEU A HB3  1 
ATOM   2616 H HG   . LEU A 1 164 ? 27.60147  -13.94421 -7.47415  1.000 14.74177  ?  245 LEU A HG   1 
ATOM   2617 H HD11 . LEU A 1 164 ? 29.82110  -15.26514 -9.09682  1.000 19.08671  ?  245 LEU A HD11 1 
ATOM   2618 H HD12 . LEU A 1 164 ? 29.12197  -13.65914 -9.44107  1.000 19.08671  ?  245 LEU A HD12 1 
ATOM   2619 H HD13 . LEU A 1 164 ? 30.02095  -13.93461 -7.92368  1.000 19.08671  ?  245 LEU A HD13 1 
ATOM   2620 H HD21 . LEU A 1 164 ? 27.38327  -14.90296 -9.98228  1.000 20.26433  ?  245 LEU A HD21 1 
ATOM   2621 H HD22 . LEU A 1 164 ? 27.09637  -16.37531 -9.01461  1.000 20.26433  ?  245 LEU A HD22 1 
ATOM   2622 H HD23 . LEU A 1 164 ? 26.09115  -14.92394 -8.75081  1.000 20.26433  ?  245 LEU A HD23 1 
ATOM   2623 N N    . THR A 1 165 ? 28.46233  -17.13244 -4.14683  1.000 11.72377  ?  246 THR A N    1 
ATOM   2624 C CA   A THR A 1 165 ? 29.04514  -18.16956 -3.29718  0.560 12.39625  ?  246 THR A CA   1 
ATOM   2625 C CA   B THR A 1 165 ? 29.02965  -18.21709 -3.36261  0.440 12.27368  ?  246 THR A CA   1 
ATOM   2626 C C    . THR A 1 165 ? 27.95116  -18.94621 -2.57354  1.000 13.67491  ?  246 THR A C    1 
ATOM   2627 O O    . THR A 1 165 ? 28.02157  -20.16617 -2.41852  1.000 15.60460  ?  246 THR A O    1 
ATOM   2628 C CB   A THR A 1 165 ? 29.96980  -17.48485 -2.26886  0.560 12.53278  ?  246 THR A CB   1 
ATOM   2629 C CB   B THR A 1 165 ? 30.12407  -17.70004 -2.43245  0.440 15.71649  ?  246 THR A CB   1 
ATOM   2630 O OG1  A THR A 1 165 ? 31.08464  -16.85737 -2.92302  0.560 17.57740  ?  246 THR A OG1  1 
ATOM   2631 O OG1  B THR A 1 165 ? 29.57609  -16.70373 -1.56273  0.440 12.26049  ?  246 THR A OG1  1 
ATOM   2632 C CG2  A THR A 1 165 ? 30.52558  -18.45106 -1.24589  0.560 19.20480  ?  246 THR A CG2  1 
ATOM   2633 C CG2  B THR A 1 165 ? 31.29168  -17.11756 -3.24177  0.440 15.75362  ?  246 THR A CG2  1 
ATOM   2634 H H    A THR A 1 165 ? 28.71349  -16.18168 -3.87592  0.930 14.06852  ?  246 THR A H    1 
ATOM   2635 D D    B THR A 1 165 ? 28.71174  -16.19001 -3.84678  0.070 14.06852  ?  246 THR A D    1 
ATOM   2636 H HA   A THR A 1 165 ? 29.62275  -18.87084 -3.89940  0.560 14.87550  ?  246 THR A HA   1 
ATOM   2637 H HA   B THR A 1 165 ? 29.49383  -18.92885 -4.04528  0.440 14.72841  ?  246 THR A HA   1 
ATOM   2638 H HB   A THR A 1 165 ? 29.36156  -16.74400 -1.74994  0.560 15.03934  ?  246 THR A HB   1 
ATOM   2639 H HB   B THR A 1 165 ? 30.51724  -18.51932 -1.83054  0.440 18.85979  ?  246 THR A HB   1 
ATOM   2640 H HG1  A THR A 1 165 ? 30.94825  -16.85923 -3.89348  0.560 21.09288  ?  246 THR A HG1  1 
ATOM   2641 H HG1  B THR A 1 165 ? 30.26630  -16.38015 -0.94685  0.440 14.71258  ?  246 THR A HG1  1 
ATOM   2642 H HG21 A THR A 1 165 ? 31.45904  -18.06463 -0.83670  0.560 23.04576  ?  246 THR A HG21 1 
ATOM   2643 H HG21 B THR A 1 165 ? 31.59731  -17.82215 -4.01523  0.440 18.90435  ?  246 THR A HG21 1 
ATOM   2644 H HG22 A THR A 1 165 ? 29.81169  -18.58496 -0.43316  0.560 23.04576  ?  246 THR A HG22 1 
ATOM   2645 H HG22 B THR A 1 165 ? 30.98837  -16.18327 -3.71422  0.440 18.90435  ?  246 THR A HG22 1 
ATOM   2646 H HG23 A THR A 1 165 ? 30.71686  -19.41783 -1.71158  0.560 23.04576  ?  246 THR A HG23 1 
ATOM   2647 H HG23 B THR A 1 165 ? 32.13984  -16.92298 -2.58537  0.440 18.90435  ?  246 THR A HG23 1 
ATOM   2648 N N    . ASN A 1 166 ? 26.95525  -18.24246 -2.05508  1.000 11.92175  ?  247 ASN A N    1 
ATOM   2649 C CA   . ASN A 1 166 ? 25.93422  -18.89249 -1.23894  1.000 11.92305  ?  247 ASN A CA   1 
ATOM   2650 C C    . ASN A 1 166 ? 24.85288  -19.57559 -2.04432  1.000 13.03717  ?  247 ASN A C    1 
ATOM   2651 O O    . ASN A 1 166 ? 24.36838  -20.62282 -1.62554  1.000 14.16923  ?  247 ASN A O    1 
ATOM   2652 C CB   . ASN A 1 166 ? 25.40108  -17.90629 -0.19793  1.000 14.96656  ?  247 ASN A CB   1 
ATOM   2653 C CG   . ASN A 1 166 ? 26.35020  -17.76439 0.94182   1.000 18.67768  ?  247 ASN A CG   1 
ATOM   2654 O OD1  . ASN A 1 166 ? 26.41460  -18.64038 1.81350   1.000 23.40948  ?  247 ASN A OD1  1 
ATOM   2655 N ND2  . ASN A 1 166 ? 27.11492  -16.70523 0.95153   1.000 16.10743  ?  247 ASN A ND2  1 
ATOM   2656 H H    A ASN A 1 166 ? 26.82557  -17.23810 -2.17697  1.000 14.30609  ?  247 ASN A H    1 
ATOM   2657 D D    B ASN A 1 166 ? 26.82399  -17.23818 -2.17590  0.000 14.30609  ?  247 ASN A D    1 
ATOM   2658 H HA   . ASN A 1 166 ? 26.38912  -19.70776 -0.67636  1.000 14.30767  ?  247 ASN A HA   1 
ATOM   2659 H HB2  . ASN A 1 166 ? 25.26835  -16.92808 -0.66010  1.000 17.95988  ?  247 ASN A HB2  1 
ATOM   2660 H HB3  . ASN A 1 166 ? 24.44856  -18.26794 0.18938   1.000 17.95988  ?  247 ASN A HB3  1 
ATOM   2661 H HD21 C ASN A 1 166 ? 27.78086  -16.56395 1.71112   0.130 19.32891  ?  247 ASN A HD21 1 
ATOM   2662 D DD21 D ASN A 1 166 ? 27.78086  -16.56395 1.71112   0.870 19.32891  ?  247 ASN A DD21 1 
ATOM   2663 H HD22 C ASN A 1 166 ? 27.04605  -16.01956 0.19953   0.200 19.32891  ?  247 ASN A HD22 1 
ATOM   2664 D DD22 D ASN A 1 166 ? 27.04605  -16.01956 0.19953   0.800 19.32891  ?  247 ASN A DD22 1 
ATOM   2665 N N    . LEU A 1 167 ? 24.46315  -19.03353 -3.20304  1.000 11.85673  ?  248 LEU A N    1 
ATOM   2666 C CA   . LEU A 1 167 ? 23.50655  -19.72649 -4.04782  1.000 11.32296  ?  248 LEU A CA   1 
ATOM   2667 C C    . LEU A 1 167 ? 24.11660  -20.96108 -4.67657  1.000 13.38768  ?  248 LEU A C    1 
ATOM   2668 O O    . LEU A 1 167 ? 23.40099  -21.93898 -4.92479  1.000 12.50294  ?  248 LEU A O    1 
ATOM   2669 C CB   . LEU A 1 167 ? 22.94041  -18.77771 -5.09608  1.000 12.46145  ?  248 LEU A CB   1 
ATOM   2670 C CG   . LEU A 1 167 ? 22.01695  -17.70354 -4.50741  1.000 13.53946  ?  248 LEU A CG   1 
ATOM   2671 C CD1  . LEU A 1 167 ? 21.72360  -16.64390 -5.57514  1.000 18.10280  ?  248 LEU A CD1  1 
ATOM   2672 C CD2  . LEU A 1 167 ? 20.73615  -18.27108 -3.96656  1.000 18.94577  ?  248 LEU A CD2  1 
ATOM   2673 H H    A LEU A 1 167 ? 24.78721  -18.13843 -3.56935  1.000 14.22808  ?  248 LEU A H    1 
ATOM   2674 D D    B LEU A 1 167 ? 24.78570  -18.13875 -3.57145  0.000 14.22808  ?  248 LEU A D    1 
ATOM   2675 H HA   . LEU A 1 167 ? 22.66453  -20.05783 -3.44010  1.000 13.58755  ?  248 LEU A HA   1 
ATOM   2676 H HB2  . LEU A 1 167 ? 23.76685  -18.27251 -5.59595  1.000 14.95374  ?  248 LEU A HB2  1 
ATOM   2677 H HB3  . LEU A 1 167 ? 22.36473  -19.35565 -5.81904  1.000 14.95374  ?  248 LEU A HB3  1 
ATOM   2678 H HG   . LEU A 1 167 ? 22.52672  -17.24317 -3.66107  1.000 16.24735  ?  248 LEU A HG   1 
ATOM   2679 H HD11 . LEU A 1 167 ? 21.23049  -15.79319 -5.10478  1.000 21.72336  ?  248 LEU A HD11 1 
ATOM   2680 H HD12 . LEU A 1 167 ? 22.66317  -16.32574 -6.02690  1.000 21.72336  ?  248 LEU A HD12 1 
ATOM   2681 H HD13 . LEU A 1 167 ? 21.07339  -17.07670 -6.33541  1.000 21.72336  ?  248 LEU A HD13 1 
ATOM   2682 H HD21 . LEU A 1 167 ? 20.92004  -19.28415 -3.60884  1.000 22.73492  ?  248 LEU A HD21 1 
ATOM   2683 H HD22 . LEU A 1 167 ? 20.38911  -17.64413 -3.14522  1.000 22.73492  ?  248 LEU A HD22 1 
ATOM   2684 H HD23 . LEU A 1 167 ? 19.99129  -18.28730 -4.76219  1.000 22.73492  ?  248 LEU A HD23 1 
ATOM   2685 N N    . ALA A 1 168 ? 25.43650  -20.95430 -4.91271  1.000 12.38120  ?  249 ALA A N    1 
ATOM   2686 C CA   . ALA A 1 168 ? 26.07908  -22.14522 -5.45506  1.000 13.01269  ?  249 ALA A CA   1 
ATOM   2687 C C    . ALA A 1 168 ? 26.00387  -23.32695 -4.49547  1.000 14.41416  ?  249 ALA A C    1 
ATOM   2688 O O    . ALA A 1 168 ? 25.91688  -24.47329 -4.93624  1.000 14.56947  ?  249 ALA A O    1 
ATOM   2689 C CB   . ALA A 1 168 ? 27.53347  -21.84514 -5.80027  1.000 14.17117  ?  249 ALA A CB   1 
ATOM   2690 H H    A ALA A 1 168 ? 26.06074  -20.16561 -4.74328  1.000 14.85744  ?  249 ALA A H    1 
ATOM   2691 D D    B ALA A 1 168 ? 26.06278  -20.16704 -4.74416  0.000 14.85744  ?  249 ALA A D    1 
ATOM   2692 H HA   . ALA A 1 168 ? 25.55861  -22.42576 -6.37076  1.000 15.61522  ?  249 ALA A HA   1 
ATOM   2693 H HB1  . ALA A 1 168 ? 27.58726  -20.87807 -6.30026  1.000 17.00540  ?  249 ALA A HB1  1 
ATOM   2694 H HB2  . ALA A 1 168 ? 28.11876  -21.82139 -4.88104  1.000 17.00540  ?  249 ALA A HB2  1 
ATOM   2695 H HB3  . ALA A 1 168 ? 27.90995  -22.62641 -6.46055  1.000 17.00540  ?  249 ALA A HB3  1 
ATOM   2696 N N    . LYS A 1 169 ? 26.02819  -23.04791 -3.19649  1.000 13.77637  ?  250 LYS A N    1 
ATOM   2697 C CA   . LYS A 1 169 ? 25.97190  -24.11472 -2.20198  1.000 15.84894  ?  250 LYS A CA   1 
ATOM   2698 C C    . LYS A 1 169 ? 24.65332  -24.86821 -2.22899  1.000 15.90063  ?  250 LYS A C    1 
ATOM   2699 O O    . LYS A 1 169 ? 24.60863  -26.02802 -1.79729  1.000 19.18343  ?  250 LYS A O    1 
ATOM   2700 C CB   . LYS A 1 169 ? 26.14630  -23.53612 -0.80257  1.000 17.42264  ?  250 LYS A CB   1 
ATOM   2701 C CG   . LYS A 1 169 ? 27.57477  -23.07749 -0.52937  1.000 18.04468  ?  250 LYS A CG   1 
ATOM   2702 C CD   . LYS A 1 169 ? 27.72702  -22.36745 0.80458   1.000 22.69704  ?  250 LYS A CD   1 
ATOM   2703 C CE   . LYS A 1 169 ? 29.18398  -21.93446 1.02345   1.000 31.04342  ?  250 LYS A CE   1 
ATOM   2704 N NZ   . LYS A 1 169 ? 29.29989  -21.02286 2.23175   1.000 36.69857  ?  250 LYS A NZ   1 
ATOM   2705 H H    A LYS A 1 169 ? 26.08558  -22.10807 -2.80432  0.440 16.53164  ?  250 LYS A H    1 
ATOM   2706 D D    B LYS A 1 169 ? 26.08555  -22.10887 -2.80241  0.560 16.53164  ?  250 LYS A D    1 
ATOM   2707 H HA   . LYS A 1 169 ? 26.78493  -24.80844 -2.41605  1.000 19.01872  ?  250 LYS A HA   1 
ATOM   2708 H HB2  . LYS A 1 169 ? 25.48759  -22.67502 -0.68985  1.000 20.90717  ?  250 LYS A HB2  1 
ATOM   2709 H HB3  . LYS A 1 169 ? 25.89040  -24.29990 -0.06823  1.000 20.90717  ?  250 LYS A HB3  1 
ATOM   2710 H HG2  . LYS A 1 169 ? 28.23111  -23.94771 -0.52260  1.000 21.65362  ?  250 LYS A HG2  1 
ATOM   2711 H HG3  . LYS A 1 169 ? 27.88097  -22.38569 -1.31407  1.000 21.65362  ?  250 LYS A HG3  1 
ATOM   2712 H HD2  . LYS A 1 169 ? 27.09539  -21.47923 0.81928   1.000 27.23645  ?  250 LYS A HD2  1 
ATOM   2713 H HD3  . LYS A 1 169 ? 27.44075  -23.04187 1.61162   1.000 27.23645  ?  250 LYS A HD3  1 
ATOM   2714 H HE2  . LYS A 1 169 ? 29.80356  -22.81497 1.19355   1.000 37.25211  ?  250 LYS A HE2  1 
ATOM   2715 H HE3  . LYS A 1 169 ? 29.53832  -21.39309 0.14627   1.000 37.25211  ?  250 LYS A HE3  1 
ATOM   2716 N N    . VAL A 1 170 ? 23.57917  -24.26583 -2.72729  1.000 13.02822  ?  251 VAL A N    1 
ATOM   2717 C CA   . VAL A 1 170 ? 22.30280  -24.93550 -2.86809  1.000 14.76930  ?  251 VAL A CA   1 
ATOM   2718 C C    . VAL A 1 170 ? 21.98377  -25.25709 -4.32958  1.000 14.37539  ?  251 VAL A C    1 
ATOM   2719 O O    . VAL A 1 170 ? 20.84152  -25.55349 -4.64597  1.000 17.44455  ?  251 VAL A O    1 
ATOM   2720 C CB   . VAL A 1 170 ? 21.15542  -24.17988 -2.17172  1.000 16.66292  ?  251 VAL A CB   1 
ATOM   2721 C CG1  . VAL A 1 170 ? 21.28679  -24.32446 -0.65210  1.000 21.61912  ?  251 VAL A CG1  1 
ATOM   2722 C CG2  . VAL A 1 170 ? 21.10752  -22.74847 -2.55534  1.000 15.68432  ?  251 VAL A CG2  1 
ATOM   2723 H H    A VAL A 1 170 ? 23.56788  -23.29699 -3.04606  0.980 15.63386  ?  251 VAL A H    1 
ATOM   2724 D D    B VAL A 1 170 ? 23.56943  -23.29684 -3.04567  0.020 15.63386  ?  251 VAL A D    1 
ATOM   2725 H HA   . VAL A 1 170 ? 22.39313  -25.89194 -2.35314  1.000 17.72316  ?  251 VAL A HA   1 
ATOM   2726 H HB   . VAL A 1 170 ? 20.21378  -24.62186 -2.49742  1.000 19.99551  ?  251 VAL A HB   1 
ATOM   2727 H HG11 . VAL A 1 170 ? 21.49788  -25.36645 -0.41170  1.000 25.94294  ?  251 VAL A HG11 1 
ATOM   2728 H HG12 . VAL A 1 170 ? 22.10226  -23.69022 -0.30447  1.000 25.94294  ?  251 VAL A HG12 1 
ATOM   2729 H HG13 . VAL A 1 170 ? 20.35150  -24.01717 -0.18422  1.000 25.94294  ?  251 VAL A HG13 1 
ATOM   2730 H HG21 . VAL A 1 170 ? 22.07334  -22.29105 -2.34071  1.000 18.82118  ?  251 VAL A HG21 1 
ATOM   2731 H HG22 . VAL A 1 170 ? 20.88935  -22.67369 -3.62066  1.000 18.82118  ?  251 VAL A HG22 1 
ATOM   2732 H HG23 . VAL A 1 170 ? 20.32548  -22.25288 -1.98008  1.000 18.82118  ?  251 VAL A HG23 1 
ATOM   2733 N N    . GLY A 1 171 ? 22.97732  -25.21371 -5.21528  1.000 13.21708  ?  252 GLY A N    1 
ATOM   2734 C CA   . GLY A 1 171 ? 22.81672  -25.75851 -6.54066  1.000 13.30669  ?  252 GLY A CA   1 
ATOM   2735 C C    . GLY A 1 171 ? 22.02459  -24.91248 -7.51336  1.000 11.09518  ?  252 GLY A C    1 
ATOM   2736 O O    . GLY A 1 171 ? 21.50549  -25.46504 -8.48530  1.000 13.17749  ?  252 GLY A O    1 
ATOM   2737 H H    A GLY A 1 171 ? 23.89594  -24.80815 -5.03624  0.010 15.86050  ?  252 GLY A H    1 
ATOM   2738 D D    B GLY A 1 171 ? 23.89628  -24.80843 -5.03734  0.990 15.86050  ?  252 GLY A D    1 
ATOM   2739 H HA2  . GLY A 1 171 ? 23.80602  -25.91242 -6.97160  1.000 15.96803  ?  252 GLY A HA2  1 
ATOM   2740 H HA3  . GLY A 1 171 ? 22.31191  -26.72104 -6.45817  1.000 15.96803  ?  252 GLY A HA3  1 
ATOM   2741 N N    . VAL A 1 172 ? 21.97302  -23.59227 -7.32462  1.000 10.90366  ?  253 VAL A N    1 
ATOM   2742 C CA   . VAL A 1 172 ? 21.28691  -22.68118 -8.23930  1.000 11.46218  ?  253 VAL A CA   1 
ATOM   2743 C C    . VAL A 1 172 ? 22.17599  -22.37568 -9.43874  1.000 11.15719  ?  253 VAL A C    1 
ATOM   2744 O O    . VAL A 1 172 ? 23.35023  -22.02396 -9.27211  1.000 12.43531  ?  253 VAL A O    1 
ATOM   2745 C CB   . VAL A 1 172 ? 20.95692  -21.38119 -7.49284  1.000 11.30356  ?  253 VAL A CB   1 
ATOM   2746 C CG1  . VAL A 1 172 ? 20.31823  -20.35539 -8.41157  1.000 12.43543  ?  253 VAL A CG1  1 
ATOM   2747 C CG2  . VAL A 1 172 ? 20.03123  -21.67359 -6.29111  1.000 13.79768  ?  253 VAL A CG2  1 
ATOM   2748 H H    A VAL A 1 172 ? 22.40484  -23.11564 -6.53294  0.910 13.08440  ?  253 VAL A H    1 
ATOM   2749 D D    B VAL A 1 172 ? 22.40481  -23.11557 -6.53296  0.090 13.08440  ?  253 VAL A D    1 
ATOM   2750 H HA   . VAL A 1 172 ? 20.37810  -23.15839 -8.60597  1.000 13.75462  ?  253 VAL A HA   1 
ATOM   2751 H HB   . VAL A 1 172 ? 21.89044  -20.95572 -7.12460  1.000 13.56428  ?  253 VAL A HB   1 
ATOM   2752 H HG11 . VAL A 1 172 ? 21.04249  -20.05879 -9.17023  1.000 14.92251  ?  253 VAL A HG11 1 
ATOM   2753 H HG12 . VAL A 1 172 ? 19.44360  -20.80004 -8.88634  1.000 14.92251  ?  253 VAL A HG12 1 
ATOM   2754 H HG13 . VAL A 1 172 ? 20.02066  -19.48792 -7.82246  1.000 14.92251  ?  253 VAL A HG13 1 
ATOM   2755 H HG21 . VAL A 1 172 ? 20.45757  -21.22026 -5.39622  1.000 16.55721  ?  253 VAL A HG21 1 
ATOM   2756 H HG22 . VAL A 1 172 ? 19.04702  -21.24941 -6.48985  1.000 16.55721  ?  253 VAL A HG22 1 
ATOM   2757 H HG23 . VAL A 1 172 ? 19.95119  -22.75260 -6.15912  1.000 16.55721  ?  253 VAL A HG23 1 
ATOM   2758 N N    . TYR A 1 173 ? 21.60927  -22.48098 -10.63342 1.000 10.21923  ?  254 TYR A N    1 
ATOM   2759 C CA   . TYR A 1 173 ? 22.31394  -22.11924 -11.84622 1.000 10.11376  ?  254 TYR A CA   1 
ATOM   2760 C C    . TYR A 1 173 ? 22.18103  -20.62822 -12.06502 1.000 10.17898  ?  254 TYR A C    1 
ATOM   2761 O O    . TYR A 1 173 ? 21.06440  -20.08958 -12.06051 1.000 13.51397  ?  254 TYR A O    1 
ATOM   2762 C CB   . TYR A 1 173 ? 21.74002  -22.88724 -13.03711 1.000 12.14842  ?  254 TYR A CB   1 
ATOM   2763 C CG   . TYR A 1 173 ? 22.21128  -24.32559 -13.02733 1.000 12.82826  ?  254 TYR A CG   1 
ATOM   2764 C CD1  . TYR A 1 173 ? 23.46270  -24.65457 -13.53565 1.000 14.77028  ?  254 TYR A CD1  1 
ATOM   2765 C CD2  . TYR A 1 173 ? 21.45239  -25.33931 -12.45470 1.000 14.91473  ?  254 TYR A CD2  1 
ATOM   2766 C CE1  . TYR A 1 173 ? 23.93025  -25.94040 -13.50528 1.000 18.17497  ?  254 TYR A CE1  1 
ATOM   2767 C CE2  . TYR A 1 173 ? 21.93581  -26.66068 -12.41053 1.000 16.33480  ?  254 TYR A CE2  1 
ATOM   2768 C CZ   . TYR A 1 173 ? 23.16632  -26.94281 -12.93654 1.000 18.79631  ?  254 TYR A CZ   1 
ATOM   2769 O OH   . TYR A 1 173 ? 23.67298  -28.24720 -12.89828 1.000 21.58576  ?  254 TYR A OH   1 
ATOM   2770 H H    A TYR A 1 173 ? 20.65868  -22.81552 -10.79114 0.950 12.26307  ?  254 TYR A H    1 
ATOM   2771 D D    B TYR A 1 173 ? 20.65873  -22.81547 -10.79151 0.050 12.26307  ?  254 TYR A D    1 
ATOM   2772 H HA   . TYR A 1 173 ? 23.37079  -22.37212 -11.76120 1.000 12.13651  ?  254 TYR A HA   1 
ATOM   2773 H HB2  . TYR A 1 173 ? 20.65135  -22.87880 -12.98406 1.000 14.57811  ?  254 TYR A HB2  1 
ATOM   2774 H HB3  . TYR A 1 173 ? 22.07172  -22.42009 -13.96439 1.000 14.57811  ?  254 TYR A HB3  1 
ATOM   2775 H HD1  . TYR A 1 173 ? 24.07948  -23.87834 -13.96395 1.000 17.72434  ?  254 TYR A HD1  1 
ATOM   2776 H HD2  . TYR A 1 173 ? 20.48193  -25.11100 -12.03938 1.000 17.89768  ?  254 TYR A HD2  1 
ATOM   2777 H HE1  . TYR A 1 173 ? 24.89739  -26.17252 -13.92617 1.000 21.80996  ?  254 TYR A HE1  1 
ATOM   2778 H HE2  . TYR A 1 173 ? 21.34057  -27.44427 -11.96546 1.000 19.60176  ?  254 TYR A HE2  1 
ATOM   2779 N N    . MET A 1 174 ? 23.29243  -19.94859 -12.24859 1.000 9.74414   ?  255 MET A N    1 
ATOM   2780 C CA   . MET A 1 174 ? 23.32043  -18.48768 -12.24051 1.000 9.86528   ?  255 MET A CA   1 
ATOM   2781 C C    . MET A 1 174 ? 23.90139  -17.88498 -13.50863 1.000 10.67068  ?  255 MET A C    1 
ATOM   2782 O O    . MET A 1 174 ? 24.90532  -18.37422 -14.05697 1.000 11.51538  ?  255 MET A O    1 
ATOM   2783 C CB   . MET A 1 174 ? 24.16147  -18.03695 -11.05843 1.000 11.05999  ?  255 MET A CB   1 
ATOM   2784 C CG   . MET A 1 174 ? 23.55236  -18.43777 -9.74493  1.000 11.41455  ?  255 MET A CG   1 
ATOM   2785 S SD   . MET A 1 174 ? 24.61813  -18.12610 -8.32036  1.000 15.21903  ?  255 MET A SD   1 
ATOM   2786 C CE   . MET A 1 174 ? 25.65581  -19.56619 -8.35449  1.000 16.90442  ?  255 MET A CE   1 
ATOM   2787 H H    A MET A 1 174 ? 24.20400  -20.37763 -12.40785 1.000 11.69297  ?  255 MET A H    1 
ATOM   2788 D D    B MET A 1 174 ? 24.20321  -20.37935 -12.40773 0.000 11.69297  ?  255 MET A D    1 
ATOM   2789 H HA   . MET A 1 174 ? 22.29362  -18.12692 -12.18022 1.000 11.83834  ?  255 MET A HA   1 
ATOM   2790 H HB2  . MET A 1 174 ? 25.14949  -18.49192 -11.12858 1.000 13.27199  ?  255 MET A HB2  1 
ATOM   2791 H HB3  . MET A 1 174 ? 24.24921  -16.95062 -11.07573 1.000 13.27199  ?  255 MET A HB3  1 
ATOM   2792 H HG2  . MET A 1 174 ? 22.63076  -17.87421 -9.59951  1.000 13.69746  ?  255 MET A HG2  1 
ATOM   2793 H HG3  . MET A 1 174 ? 23.33617  -19.50582 -9.77028  1.000 13.69746  ?  255 MET A HG3  1 
ATOM   2794 H HE1  . MET A 1 174 ? 25.41159  -20.15875 -9.23616  1.000 20.28530  ?  255 MET A HE1  1 
ATOM   2795 H HE2  . MET A 1 174 ? 26.69855  -19.25133 -8.39541  1.000 20.28530  ?  255 MET A HE2  1 
ATOM   2796 H HE3  . MET A 1 174 ? 25.47957  -20.15205 -7.45238  1.000 20.28530  ?  255 MET A HE3  1 
ATOM   2797 N N    . TYR A 1 175 ? 23.27778  -16.80633 -13.95621 1.000 10.07644  ?  256 TYR A N    1 
ATOM   2798 C CA   . TYR A 1 175 ? 23.76228  -16.01126 -15.06199 1.000 9.33522   ?  256 TYR A CA   1 
ATOM   2799 C C    . TYR A 1 175 ? 23.85717  -14.59213 -14.55364 1.000 10.24465  ?  256 TYR A C    1 
ATOM   2800 O O    . TYR A 1 175 ? 22.83817  -13.99703 -14.15396 1.000 11.34406  ?  256 TYR A O    1 
ATOM   2801 C CB   . TYR A 1 175 ? 22.79910  -16.08833 -16.25730 1.000 10.24165  ?  256 TYR A CB   1 
ATOM   2802 C CG   . TYR A 1 175 ? 22.70788  -17.45705 -16.86518 1.000 10.27921  ?  256 TYR A CG   1 
ATOM   2803 C CD1  . TYR A 1 175 ? 21.81982  -18.40087 -16.33846 1.000 10.97123  ?  256 TYR A CD1  1 
ATOM   2804 C CD2  . TYR A 1 175 ? 23.49036  -17.82154 -17.94928 1.000 10.69296  ?  256 TYR A CD2  1 
ATOM   2805 C CE1  . TYR A 1 175 ? 21.73171  -19.67627 -16.87404 1.000 12.04940  ?  256 TYR A CE1  1 
ATOM   2806 C CE2  . TYR A 1 175 ? 23.40915  -19.09358 -18.48933 1.000 11.15740  ?  256 TYR A CE2  1 
ATOM   2807 C CZ   . TYR A 1 175 ? 22.52276  -19.99858 -17.96206 1.000 12.18595  ?  256 TYR A CZ   1 
ATOM   2808 O OH   . TYR A 1 175 ? 22.37180  -21.29248 -18.45773 1.000 13.60178  ?  256 TYR A OH   1 
ATOM   2809 H H    A TYR A 1 175 ? 22.40849  -16.45179 -13.55743 1.000 12.09173  ?  256 TYR A H    1 
ATOM   2810 D D    B TYR A 1 175 ? 22.40849  -16.45360 -13.55581 0.000 12.09173  ?  256 TYR A D    1 
ATOM   2811 H HA   . TYR A 1 175 ? 24.73966  -16.35838 -15.39715 1.000 11.20226  ?  256 TYR A HA   1 
ATOM   2812 H HB2  . TYR A 1 175 ? 21.80117  -15.80405 -15.92349 1.000 12.28998  ?  256 TYR A HB2  1 
ATOM   2813 H HB3  . TYR A 1 175 ? 23.14315  -15.40171 -17.03079 1.000 12.28998  ?  256 TYR A HB3  1 
ATOM   2814 H HD1  . TYR A 1 175 ? 21.19295  -18.13154 -15.50126 1.000 13.16547  ?  256 TYR A HD1  1 
ATOM   2815 H HD2  . TYR A 1 175 ? 24.17300  -17.10325 -18.37877 1.000 12.83155  ?  256 TYR A HD2  1 
ATOM   2816 H HE1  . TYR A 1 175 ? 21.05748  -20.40535 -16.44945 1.000 14.45928  ?  256 TYR A HE1  1 
ATOM   2817 H HE2  . TYR A 1 175 ? 24.03972  -19.37201 -19.32074 1.000 13.38888  ?  256 TYR A HE2  1 
ATOM   2818 H HH   A TYR A 1 175 ? 22.72736  -21.34577 -19.36940 0.000 16.32214  ?  256 TYR A HH   1 
ATOM   2819 D DH   B TYR A 1 175 ? 22.86886  -21.39015 -19.29666 1.000 16.32214  ?  256 TYR A DH   1 
ATOM   2820 N N    . MET A 1 176 ? 25.03276  -14.00395 -14.58272 1.000 9.65321   ?  257 MET A N    1 
ATOM   2821 C CA   . MET A 1 176 ? 25.17587  -12.62892 -14.13017 1.000 10.43482  ?  257 MET A CA   1 
ATOM   2822 C C    . MET A 1 176 ? 24.75418  -11.67662 -15.22397 1.000 9.81917   ?  257 MET A C    1 
ATOM   2823 O O    . MET A 1 176 ? 25.03064  -11.89111 -16.40352 1.000 10.90478  ?  257 MET A O    1 
ATOM   2824 C CB   . MET A 1 176 ? 26.64252  -12.34111 -13.82466 1.000 13.36407  ?  257 MET A CB   1 
ATOM   2825 C CG   . MET A 1 176 ? 27.11944  -13.00312 -12.56938 1.000 15.42653  ?  257 MET A CG   1 
ATOM   2826 S SD   . MET A 1 176 ? 28.80144  -12.53367 -12.13387 1.000 19.67361  ?  257 MET A SD   1 
ATOM   2827 C CE   . MET A 1 176 ? 29.66319  -13.57099 -13.24128 1.000 24.13761  ?  257 MET A CE   1 
ATOM   2828 H H    . MET A 1 176 ? 25.89565  -14.44007 -14.90773 1.000 11.58385  ?  257 MET A H    1 
ATOM   2829 H HA   . MET A 1 176 ? 24.56876  -12.48560 -13.23631 1.000 12.52178  ?  257 MET A HA   1 
ATOM   2830 H HB2  . MET A 1 176 ? 27.25385  -12.70545 -14.65027 1.000 16.03688  ?  257 MET A HB2  1 
ATOM   2831 H HB3  . MET A 1 176 ? 26.77517  -11.26541 -13.70895 1.000 16.03688  ?  257 MET A HB3  1 
ATOM   2832 H HG2  . MET A 1 176 ? 26.46519  -12.71705 -11.74584 1.000 18.51184  ?  257 MET A HG2  1 
ATOM   2833 H HG3  . MET A 1 176 ? 27.09546  -14.08421 -12.70632 1.000 18.51184  ?  257 MET A HG3  1 
ATOM   2834 H HE1  . MET A 1 176 ? 29.27320  -14.58509 -13.15402 1.000 28.96513  ?  257 MET A HE1  1 
ATOM   2835 H HE2  . MET A 1 176 ? 29.51879  -13.20335 -14.25720 1.000 28.96513  ?  257 MET A HE2  1 
ATOM   2836 H HE3  . MET A 1 176 ? 30.72332  -13.55739 -12.98823 1.000 28.96513  ?  257 MET A HE3  1 
ATOM   2837 N N    . ASP A 1 177 ? 24.07865  -10.59363 -14.85134 1.000 9.58361   ?  258 ASP A N    1 
ATOM   2838 C CA   . ASP A 1 177 ? 23.69400  -9.61495  -15.85639 1.000 10.04875  ?  258 ASP A CA   1 
ATOM   2839 C C    . ASP A 1 177 ? 24.92978  -9.00814  -16.50092 1.000 10.56241  ?  258 ASP A C    1 
ATOM   2840 O O    . ASP A 1 177 ? 25.88136  -8.62546  -15.82217 1.000 12.41085  ?  258 ASP A O    1 
ATOM   2841 C CB   . ASP A 1 177 ? 22.86054  -8.50491  -15.24178 1.000 10.47330  ?  258 ASP A CB   1 
ATOM   2842 C CG   . ASP A 1 177 ? 22.42614  -7.52499  -16.26791 1.000 11.93734  ?  258 ASP A CG   1 
ATOM   2843 O OD1  . ASP A 1 177 ? 21.38407  -7.80590  -16.87301 1.000 13.74077  ?  258 ASP A OD1  1 
ATOM   2844 O OD2  . ASP A 1 177 ? 23.12132  -6.53598  -16.50054 1.000 13.10108  -1 258 ASP A OD2  1 
ATOM   2845 H H    A ASP A 1 177 ? 23.79418  -10.37488 -13.89655 1.000 11.50033  ?  258 ASP A H    1 
ATOM   2846 D D    B ASP A 1 177 ? 23.79354  -10.37360 -13.89703 0.000 11.50033  ?  258 ASP A D    1 
ATOM   2847 H HA   . ASP A 1 177 ? 23.09519  -10.11254 -16.61923 1.000 12.05850  ?  258 ASP A HA   1 
ATOM   2848 H HB2  . ASP A 1 177 ? 21.97221  -8.93422  -14.77846 1.000 12.56797  ?  258 ASP A HB2  1 
ATOM   2849 H HB3  . ASP A 1 177 ? 23.45405  -7.97922  -14.49378 1.000 12.56797  ?  258 ASP A HB3  1 
ATOM   2850 N N    . ALA A 1 178 ? 24.87951  -8.85299  -17.81946 1.000 10.02239  ?  259 ALA A N    1 
ATOM   2851 C CA   . ALA A 1 178 ? 25.97527  -8.28709  -18.59218 1.000 11.50646  ?  259 ALA A CA   1 
ATOM   2852 C C    . ALA A 1 178 ? 25.50407  -7.20885  -19.55873 1.000 11.20585  ?  259 ALA A C    1 
ATOM   2853 O O    . ALA A 1 178 ? 26.04077  -7.07470  -20.66905 1.000 12.28609  ?  259 ALA A O    1 
ATOM   2854 C CB   . ALA A 1 178 ? 26.78706  -9.37622  -19.31362 1.000 12.51919  ?  259 ALA A CB   1 
ATOM   2855 H H    A ALA A 1 178 ? 24.07612  -9.11575  -18.39036 0.970 12.02687  ?  259 ALA A H    1 
ATOM   2856 D D    B ALA A 1 178 ? 24.07540  -9.11622  -18.38913 0.030 12.02687  ?  259 ALA A D    1 
ATOM   2857 H HA   . ALA A 1 178 ? 26.65166  -7.79815  -17.89109 1.000 13.80775  ?  259 ALA A HA   1 
ATOM   2858 H HB1  . ALA A 1 178 ? 26.44530  -9.44814  -20.34616 1.000 15.02302  ?  259 ALA A HB1  1 
ATOM   2859 H HB2  . ALA A 1 178 ? 27.84286  -9.10640  -19.28950 1.000 15.02302  ?  259 ALA A HB2  1 
ATOM   2860 H HB3  . ALA A 1 178 ? 26.63491  -10.32796 -18.80458 1.000 15.02302  ?  259 ALA A HB3  1 
ATOM   2861 N N    . GLY A 1 179 ? 24.52575  -6.40360  -19.16792 1.000 10.46157  ?  260 GLY A N    1 
ATOM   2862 C CA   . GLY A 1 179 ? 24.13075  -5.33239  -20.04667 1.000 11.22797  ?  260 GLY A CA   1 
ATOM   2863 C C    . GLY A 1 179 ? 23.62128  -5.84296  -21.37980 1.000 11.18400  ?  260 GLY A C    1 
ATOM   2864 O O    . GLY A 1 179 ? 22.92689  -6.85026  -21.47051 1.000 11.47547  ?  260 GLY A O    1 
ATOM   2865 H H    A GLY A 1 179 ? 24.01431  -6.46904  -18.28784 0.070 12.55388  ?  260 GLY A H    1 
ATOM   2866 D D    B GLY A 1 179 ? 24.01268  -6.46668  -18.28861 0.930 12.55388  ?  260 GLY A D    1 
ATOM   2867 H HA2  . GLY A 1 179 ? 23.33817  -4.75129  -19.57526 1.000 13.47356  ?  260 GLY A HA2  1 
ATOM   2868 H HA3  . GLY A 1 179 ? 24.98573  -4.68203  -20.23142 1.000 13.47356  ?  260 GLY A HA3  1 
ATOM   2869 N N    . HIS A 1 180 ? 23.96377  -5.11950  -22.45853 1.000 10.64507  ?  261 HIS A N    1 
ATOM   2870 C CA   . HIS A 1 180 ? 23.49179  -5.41465  -23.79642 1.000 11.32934  ?  261 HIS A CA   1 
ATOM   2871 C C    . HIS A 1 180 ? 24.50597  -4.87925  -24.80605 1.000 10.80221  ?  261 HIS A C    1 
ATOM   2872 O O    . HIS A 1 180 ? 25.48095  -4.23075  -24.44435 1.000 11.40827  ?  261 HIS A O    1 
ATOM   2873 C CB   . HIS A 1 180 ? 22.07032  -4.87871  -24.00853 1.000 11.48855  ?  261 HIS A CB   1 
ATOM   2874 C CG   . HIS A 1 180 ? 21.94978  -3.38334  -23.96006 1.000 12.11814  ?  261 HIS A CG   1 
ATOM   2875 N ND1  . HIS A 1 180 ? 22.12999  -2.56164  -25.06319 1.000 13.06637  ?  261 HIS A ND1  1 
ATOM   2876 C CD2  . HIS A 1 180 ? 21.61888  -2.56008  -22.93067 1.000 15.08748  ?  261 HIS A CD2  1 
ATOM   2877 C CE1  . HIS A 1 180 ? 21.93734  -1.30353  -24.69913 1.000 15.26019  ?  261 HIS A CE1  1 
ATOM   2878 N NE2  . HIS A 1 180 ? 21.63561  -1.27497  -23.41180 1.000 16.07049  ?  261 HIS A NE2  1 
ATOM   2879 H H    A HIS A 1 180 ? 24.58079  -4.30811  -22.42202 0.910 12.77408  ?  261 HIS A H    1 
ATOM   2880 D D    B HIS A 1 180 ? 24.58087  -4.30820  -22.42124 0.090 12.77408  ?  261 HIS A D    1 
ATOM   2881 H HA   . HIS A 1 180 ? 23.44929  -6.49428  -23.94029 1.000 13.59521  ?  261 HIS A HA   1 
ATOM   2882 H HB2  . HIS A 1 180 ? 21.71993  -5.20453  -24.98790 1.000 13.78626  ?  261 HIS A HB2  1 
ATOM   2883 H HB3  . HIS A 1 180 ? 21.42693  -5.28519  -23.22820 1.000 13.78626  ?  261 HIS A HB3  1 
ATOM   2884 H HD2  . HIS A 1 180 ? 21.38572  -2.86164  -21.92017 1.000 18.10497  ?  261 HIS A HD2  1 
ATOM   2885 H HE1  . HIS A 1 180 ? 22.01394  -0.44251  -25.34656 1.000 18.31223  ?  261 HIS A HE1  1 
ATOM   2886 H HE2  A HIS A 1 180 ? 21.44620  -0.43466  -22.86554 0.000 19.28458  ?  261 HIS A HE2  1 
ATOM   2887 D DE2  B HIS A 1 180 ? 21.44620  -0.43466  -22.86554 1.000 19.28458  ?  261 HIS A DE2  1 
ATOM   2888 N N    . ALA A 1 181 ? 24.25572  -5.16865  -26.08228 1.000 10.39595  ?  262 ALA A N    1 
ATOM   2889 C CA   . ALA A 1 181 ? 25.18959  -4.78486  -27.14445 1.000 12.04880  ?  262 ALA A CA   1 
ATOM   2890 C C    . ALA A 1 181 ? 25.49565  -3.28957  -27.15457 1.000 11.56488  ?  262 ALA A C    1 
ATOM   2891 O O    . ALA A 1 181 ? 26.63724  -2.93180  -27.45937 1.000 13.84259  ?  262 ALA A O    1 
ATOM   2892 C CB   . ALA A 1 181 ? 24.65006  -5.21106  -28.49749 1.000 13.34951  ?  262 ALA A CB   1 
ATOM   2893 H H    A ALA A 1 181 ? 23.42648  -5.66175  -26.41337 0.760 12.47514  ?  262 ALA A H    1 
ATOM   2894 D D    B ALA A 1 181 ? 23.42739  -5.66155  -26.41593 0.240 12.47514  ?  262 ALA A D    1 
ATOM   2895 H HA   . ALA A 1 181 ? 26.12800  -5.30862  -26.96234 1.000 14.45856  ?  262 ALA A HA   1 
ATOM   2896 H HB1  . ALA A 1 181 ? 23.68825  -4.72624  -28.66475 1.000 16.01942  ?  262 ALA A HB1  1 
ATOM   2897 H HB2  . ALA A 1 181 ? 25.35673  -4.91186  -29.27158 1.000 16.01942  ?  262 ALA A HB2  1 
ATOM   2898 H HB3  . ALA A 1 181 ? 24.52676  -6.29403  -28.50526 1.000 16.01942  ?  262 ALA A HB3  1 
ATOM   2899 N N    . GLY A 1 182 ? 24.54055  -2.44699  -26.82079 1.000 11.44146  ?  263 GLY A N    1 
ATOM   2900 C CA   . GLY A 1 182 ? 24.74746  -1.01450  -26.86280 1.000 13.46504  ?  263 GLY A CA   1 
ATOM   2901 C C    . GLY A 1 182 ? 25.36327  -0.46169  -25.61026 1.000 13.92823  ?  263 GLY A C    1 
ATOM   2902 O O    . GLY A 1 182 ? 25.62046  0.74815   -25.51494 1.000 14.50360  ?  263 GLY A O    1 
ATOM   2903 H H    A GLY A 1 182 ? 23.60820  -2.72629  -26.51564 0.000 13.72975  ?  263 GLY A H    1 
ATOM   2904 D D    B GLY A 1 182 ? 23.60855  -2.72763  -26.51578 1.000 13.72975  ?  263 GLY A D    1 
ATOM   2905 H HA2  . GLY A 1 182 ? 25.40534  -0.77529  -27.69830 1.000 16.15804  ?  263 GLY A HA2  1 
ATOM   2906 H HA3  . GLY A 1 182 ? 23.78726  -0.52153  -27.01476 1.000 16.15804  ?  263 GLY A HA3  1 
ATOM   2907 N N    . TRP A 1 183 ? 25.66382  -1.32429  -24.63499 1.000 12.88112  ?  264 TRP A N    1 
ATOM   2908 C CA   . TRP A 1 183 ? 26.33231  -0.91546  -23.40634 1.000 12.15003  ?  264 TRP A CA   1 
ATOM   2909 C C    . TRP A 1 183 ? 27.72897  -1.49349  -23.38901 1.000 13.18258  ?  264 TRP A C    1 
ATOM   2910 O O    . TRP A 1 183 ? 28.71383  -0.75416  -23.48567 1.000 15.15990  ?  264 TRP A O    1 
ATOM   2911 C CB   . TRP A 1 183 ? 25.52543  -1.40034  -22.20461 1.000 13.46317  ?  264 TRP A CB   1 
ATOM   2912 C CG   . TRP A 1 183 ? 25.94077  -0.80418  -20.88220 1.000 12.13666  ?  264 TRP A CG   1 
ATOM   2913 C CD1  . TRP A 1 183 ? 27.07187  -0.09714  -20.61779 1.000 14.64731  ?  264 TRP A CD1  1 
ATOM   2914 C CD2  . TRP A 1 183 ? 25.20415  -0.86450  -19.66130 1.000 12.99102  ?  264 TRP A CD2  1 
ATOM   2915 N NE1  . TRP A 1 183 ? 27.09019  0.28910   -19.29193 1.000 15.27753  ?  264 TRP A NE1  1 
ATOM   2916 C CE2  . TRP A 1 183 ? 25.95555  -0.16697  -18.68915 1.000 13.02198  ?  264 TRP A CE2  1 
ATOM   2917 C CE3  . TRP A 1 183 ? 23.99503  -1.43333  -19.30293 1.000 14.46238  ?  264 TRP A CE3  1 
ATOM   2918 C CZ2  . TRP A 1 183 ? 25.51781  -0.02478  -17.35294 1.000 15.74462  ?  264 TRP A CZ2  1 
ATOM   2919 C CZ3  . TRP A 1 183 ? 23.55426  -1.28996  -17.96320 1.000 16.51361  ?  264 TRP A CZ3  1 
ATOM   2920 C CH2  . TRP A 1 183 ? 24.31807  -0.59198  -17.02805 1.000 15.80091  ?  264 TRP A CH2  1 
ATOM   2921 H H    A TRP A 1 183 ? 25.45263  -2.32149  -24.67237 0.930 15.45735  ?  264 TRP A H    1 
ATOM   2922 D D    B TRP A 1 183 ? 25.45206  -2.32132  -24.67362 0.070 15.45735  ?  264 TRP A D    1 
ATOM   2923 H HA   . TRP A 1 183 ? 26.40352  0.17099   -23.35475 1.000 14.58003  ?  264 TRP A HA   1 
ATOM   2924 H HB2  . TRP A 1 183 ? 24.47807  -1.14452  -22.36495 1.000 16.15580  ?  264 TRP A HB2  1 
ATOM   2925 H HB3  . TRP A 1 183 ? 25.63726  -2.48175  -22.12618 1.000 16.15580  ?  264 TRP A HB3  1 
ATOM   2926 H HD1  . TRP A 1 183 ? 27.84311  0.12924   -21.33913 1.000 17.57678  ?  264 TRP A HD1  1 
ATOM   2927 H HE1  A TRP A 1 183 ? 27.82962  0.82624   -18.83903 0.000 18.33303  ?  264 TRP A HE1  1 
ATOM   2928 D DE1  B TRP A 1 183 ? 27.82962  0.82624   -18.83903 1.000 18.33303  ?  264 TRP A DE1  1 
ATOM   2929 H HE3  . TRP A 1 183 ? 23.40160  -1.97326  -20.02592 1.000 17.35485  ?  264 TRP A HE3  1 
ATOM   2930 H HZ2  . TRP A 1 183 ? 26.10580  0.50879   -16.62084 1.000 18.89355  ?  264 TRP A HZ2  1 
ATOM   2931 H HZ3  . TRP A 1 183 ? 22.61372  -1.72741  -17.66247 1.000 19.81633  ?  264 TRP A HZ3  1 
ATOM   2932 H HH2  . TRP A 1 183 ? 23.95027  -0.49703  -16.01705 1.000 18.96110  ?  264 TRP A HH2  1 
ATOM   2933 N N    . LEU A 1 184 ? 27.86979  -2.80278  -23.22155 1.000 12.47235  ?  265 LEU A N    1 
ATOM   2934 C CA   . LEU A 1 184 ? 29.16614  -3.44488  -23.14333 1.000 11.80666  ?  265 LEU A CA   1 
ATOM   2935 C C    . LEU A 1 184 ? 29.65956  -4.01398  -24.46657 1.000 12.48756  ?  265 LEU A C    1 
ATOM   2936 O O    . LEU A 1 184 ? 30.79687  -4.48516  -24.52866 1.000 15.19270  ?  265 LEU A O    1 
ATOM   2937 C CB   . LEU A 1 184 ? 29.15695  -4.54137  -22.07584 1.000 13.93934  ?  265 LEU A CB   1 
ATOM   2938 C CG   . LEU A 1 184 ? 28.83144  -4.03951  -20.66601 1.000 13.09474  ?  265 LEU A CG   1 
ATOM   2939 C CD1  . LEU A 1 184 ? 28.95551  -5.20210  -19.67198 1.000 14.84276  ?  265 LEU A CD1  1 
ATOM   2940 C CD2  . LEU A 1 184 ? 29.71895  -2.87827  -20.24255 1.000 18.10867  ?  265 LEU A CD2  1 
ATOM   2941 H H    A LEU A 1 184 ? 27.08812  -3.45242  -23.13575 0.940 14.96682  ?  265 LEU A H    1 
ATOM   2942 D D    B LEU A 1 184 ? 27.08745  -3.45162  -23.13585 0.060 14.96682  ?  265 LEU A D    1 
ATOM   2943 H HA   . LEU A 1 184 ? 29.89391  -2.69398  -22.83575 1.000 14.16799  ?  265 LEU A HA   1 
ATOM   2944 H HB2  . LEU A 1 184 ? 28.40553  -5.28346  -22.34558 1.000 16.72721  ?  265 LEU A HB2  1 
ATOM   2945 H HB3  . LEU A 1 184 ? 30.14329  -5.00419  -22.04376 1.000 16.72721  ?  265 LEU A HB3  1 
ATOM   2946 H HG   . LEU A 1 184 ? 27.80929  -3.66097  -20.66145 1.000 15.71369  ?  265 LEU A HG   1 
ATOM   2947 H HD11 . LEU A 1 184 ? 28.16028  -5.92173  -19.86652 1.000 17.81131  ?  265 LEU A HD11 1 
ATOM   2948 H HD12 . LEU A 1 184 ? 29.92747  -5.67800  -19.80204 1.000 17.81131  ?  265 LEU A HD12 1 
ATOM   2949 H HD13 . LEU A 1 184 ? 28.86485  -4.81307  -18.65781 1.000 17.81131  ?  265 LEU A HD13 1 
ATOM   2950 H HD21 . LEU A 1 184 ? 29.46144  -2.58789  -19.22399 1.000 21.73041  ?  265 LEU A HD21 1 
ATOM   2951 H HD22 . LEU A 1 184 ? 30.76134  -3.19379  -20.28684 1.000 21.73041  ?  265 LEU A HD22 1 
ATOM   2952 H HD23 . LEU A 1 184 ? 29.55499  -2.04071  -20.92056 1.000 21.73041  ?  265 LEU A HD23 1 
ATOM   2953 N N    . GLY A 1 185 ? 28.84625  -3.99655  -25.50727 1.000 12.82155  ?  266 GLY A N    1 
ATOM   2954 C CA   . GLY A 1 185 ? 29.22586  -4.56856  -26.79007 1.000 13.59491  ?  266 GLY A CA   1 
ATOM   2955 C C    . GLY A 1 185 ? 30.07539  -3.68247  -27.66137 1.000 14.74929  ?  266 GLY A C    1 
ATOM   2956 O O    . GLY A 1 185 ? 30.62965  -4.18696  -28.63978 1.000 16.67372  ?  266 GLY A O    1 
ATOM   2957 H H    A GLY A 1 185 ? 27.91018  -3.59150  -25.49757 0.860 15.38585  ?  266 GLY A H    1 
ATOM   2958 D D    B GLY A 1 185 ? 27.91010  -3.59167  -25.49823 0.140 15.38585  ?  266 GLY A D    1 
ATOM   2959 H HA2  . GLY A 1 185 ? 29.78372  -5.48736  -26.60923 1.000 16.31390  ?  266 GLY A HA2  1 
ATOM   2960 H HA3  . GLY A 1 185 ? 28.31913  -4.80748  -27.34580 1.000 16.31390  ?  266 GLY A HA3  1 
ATOM   2961 N N    . TRP A 1 186 ? 30.15669  -2.38975  -27.34998 1.000 14.96363  ?  267 TRP A N    1 
ATOM   2962 C CA   . TRP A 1 186 ? 31.14402  -1.51616  -27.98818 1.000 14.01247  ?  267 TRP A CA   1 
ATOM   2963 C C    . TRP A 1 186 ? 32.49727  -2.20710  -27.93035 1.000 14.47991  ?  267 TRP A C    1 
ATOM   2964 O O    . TRP A 1 186 ? 32.89836  -2.67036  -26.86347 1.000 15.25444  ?  267 TRP A O    1 
ATOM   2965 C CB   . TRP A 1 186 ? 31.19033  -0.14519  -27.29526 1.000 14.93920  ?  267 TRP A CB   1 
ATOM   2966 C CG   . TRP A 1 186 ? 29.91996  0.64064   -27.54345 1.000 15.06384  ?  267 TRP A CG   1 
ATOM   2967 C CD1  . TRP A 1 186 ? 28.77991  0.67590   -26.78621 1.000 13.94625  ?  267 TRP A CD1  1 
ATOM   2968 C CD2  . TRP A 1 186 ? 29.66465  1.48842   -28.65482 1.000 13.40118  ?  267 TRP A CD2  1 
ATOM   2969 N NE1  . TRP A 1 186 ? 27.83494  1.48144   -27.36037 1.000 15.74056  ?  267 TRP A NE1  1 
ATOM   2970 C CE2  . TRP A 1 186 ? 28.35827  2.00534   -28.51759 1.000 14.81802  ?  267 TRP A CE2  1 
ATOM   2971 C CE3  . TRP A 1 186 ? 30.42448  1.86325   -29.75957 1.000 14.55082  ?  267 TRP A CE3  1 
ATOM   2972 C CZ2  . TRP A 1 186 ? 27.80776  2.87044   -29.44770 1.000 17.01276  ?  267 TRP A CZ2  1 
ATOM   2973 C CZ3  . TRP A 1 186 ? 29.88289  2.72262   -30.67294 1.000 19.35108  ?  267 TRP A CZ3  1 
ATOM   2974 C CH2  . TRP A 1 186 ? 28.60034  3.22131   -30.52542 1.000 18.25178  ?  267 TRP A CH2  1 
ATOM   2975 H H    A TRP A 1 186 ? 29.56128  -1.91988  -26.66798 0.940 17.95636  ?  267 TRP A H    1 
ATOM   2976 D D    B TRP A 1 186 ? 29.56207  -1.91847  -26.66828 0.060 17.95636  ?  267 TRP A D    1 
ATOM   2977 H HA   . TRP A 1 186 ? 30.87882  -1.32974  -29.02887 1.000 16.81496  ?  267 TRP A HA   1 
ATOM   2978 H HB2  . TRP A 1 186 ? 31.30249  -0.28753  -26.22043 1.000 17.92704  ?  267 TRP A HB2  1 
ATOM   2979 H HB3  . TRP A 1 186 ? 32.03137  0.42816   -27.68516 1.000 17.92704  ?  267 TRP A HB3  1 
ATOM   2980 H HD1  . TRP A 1 186 ? 28.64458  0.13914   -25.85886 1.000 16.73549  ?  267 TRP A HD1  1 
ATOM   2981 H HE1  A TRP A 1 186 ? 26.90108  1.66225   -26.99210 0.170 18.88867  ?  267 TRP A HE1  1 
ATOM   2982 D DE1  B TRP A 1 186 ? 26.90108  1.66225   -26.99210 0.830 18.88867  ?  267 TRP A DE1  1 
ATOM   2983 H HE3  . TRP A 1 186 ? 31.42575  1.48083   -29.89229 1.000 17.46098  ?  267 TRP A HE3  1 
ATOM   2984 H HZ2  . TRP A 1 186 ? 26.80434  3.25414   -29.33669 1.000 20.41532  ?  267 TRP A HZ2  1 
ATOM   2985 H HZ3  . TRP A 1 186 ? 30.46910  3.01975   -31.52995 1.000 23.22130  ?  267 TRP A HZ3  1 
ATOM   2986 H HH2  . TRP A 1 186 ? 28.20942  3.90006   -31.26898 1.000 21.90213  ?  267 TRP A HH2  1 
ATOM   2987 N N    . PRO A 1 187 ? 33.24047  -2.29154  -29.05508 1.000 15.65374  ?  268 PRO A N    1 
ATOM   2988 C CA   . PRO A 1 187 ? 34.51273  -3.03277  -29.03353 1.000 15.50184  ?  268 PRO A CA   1 
ATOM   2989 C C    . PRO A 1 187 ? 35.45565  -2.61947  -27.93444 1.000 15.49425  ?  268 PRO A C    1 
ATOM   2990 O O    . PRO A 1 187 ? 36.12625  -3.45868  -27.32474 1.000 18.00530  ?  268 PRO A O    1 
ATOM   2991 C CB   . PRO A 1 187 ? 35.08379  -2.78618  -30.43660 1.000 18.80447  ?  268 PRO A CB   1 
ATOM   2992 C CG   . PRO A 1 187 ? 33.80287  -2.74249  -31.31360 1.000 21.58702  ?  268 PRO A CG   1 
ATOM   2993 C CD   . PRO A 1 187 ? 32.77029  -2.04136  -30.43169 1.000 17.32668  ?  268 PRO A CD   1 
ATOM   2994 H HA   . PRO A 1 187 ? 34.30906  -4.09754  -28.92010 1.000 18.60221  ?  268 PRO A HA   1 
ATOM   2995 H HB2  . PRO A 1 187 ? 35.62438  -1.84024  -30.46924 1.000 22.56536  ?  268 PRO A HB2  1 
ATOM   2996 H HB3  . PRO A 1 187 ? 35.74322  -3.60276  -30.73062 1.000 22.56536  ?  268 PRO A HB3  1 
ATOM   2997 H HG2  . PRO A 1 187 ? 33.99117  -2.17531  -32.22517 1.000 25.90442  ?  268 PRO A HG2  1 
ATOM   2998 H HG3  . PRO A 1 187 ? 33.48416  -3.75450  -31.56334 1.000 25.90442  ?  268 PRO A HG3  1 
ATOM   2999 H HD2  . PRO A 1 187 ? 32.74853  -0.97201  -30.64173 1.000 20.79202  ?  268 PRO A HD2  1 
ATOM   3000 H HD3  . PRO A 1 187 ? 31.78024  -2.47132  -30.58349 1.000 20.79202  ?  268 PRO A HD3  1 
ATOM   3001 N N    . ALA A 1 188 ? 35.50260  -1.32793  -27.61776 1.000 14.80931  ?  269 ALA A N    1 
ATOM   3002 C CA   . ALA A 1 188 ? 36.42374  -0.86038  -26.60134 1.000 14.16356  ?  269 ALA A CA   1 
ATOM   3003 C C    . ALA A 1 188 ? 36.01471  -1.27282  -25.19234 1.000 15.65056  ?  269 ALA A C    1 
ATOM   3004 O O    . ALA A 1 188 ? 36.82556  -1.17409  -24.26850 1.000 17.82692  ?  269 ALA A O    1 
ATOM   3005 C CB   . ALA A 1 188 ? 36.49388  0.66454   -26.66266 1.000 18.44847  ?  269 ALA A CB   1 
ATOM   3006 H H    A ALA A 1 188 ? 34.92619  -0.60038  -28.04064 0.100 17.77117  ?  269 ALA A H    1 
ATOM   3007 D D    B ALA A 1 188 ? 34.92699  -0.59914  -28.03958 0.900 17.77117  ?  269 ALA A D    1 
ATOM   3008 H HA   . ALA A 1 188 ? 37.40693  -1.28623  -26.80155 1.000 16.99628  ?  269 ALA A HA   1 
ATOM   3009 H HB1  . ALA A 1 188 ? 37.02151  0.95932   -27.56974 1.000 22.13817  ?  269 ALA A HB1  1 
ATOM   3010 H HB2  . ALA A 1 188 ? 35.48065  1.06618   -26.67486 1.000 22.13817  ?  269 ALA A HB2  1 
ATOM   3011 H HB3  . ALA A 1 188 ? 37.02835  1.03073   -25.78611 1.000 22.13817  ?  269 ALA A HB3  1 
ATOM   3012 N N    . ASN A 1 189 ? 34.75737  -1.68750  -24.99282 1.000 13.74388  ?  270 ASN A N    1 
ATOM   3013 C CA   . ASN A 1 189 ? 34.30364  -2.07894  -23.66323 1.000 14.96445  ?  270 ASN A CA   1 
ATOM   3014 C C    . ASN A 1 189 ? 34.41085  -3.57406  -23.43034 1.000 14.28078  ?  270 ASN A C    1 
ATOM   3015 O O    . ASN A 1 189 ? 34.25591  -4.02063  -22.28422 1.000 15.09774  ?  270 ASN A O    1 
ATOM   3016 C CB   . ASN A 1 189 ? 32.84179  -1.65631  -23.44264 1.000 14.39351  ?  270 ASN A CB   1 
ATOM   3017 C CG   . ASN A 1 189 ? 32.66660  -0.14436  -23.38978 1.000 16.73220  ?  270 ASN A CG   1 
ATOM   3018 O OD1  . ASN A 1 189 ? 33.63518  0.58944   -23.18179 1.000 18.42278  ?  270 ASN A OD1  1 
ATOM   3019 N ND2  . ASN A 1 189 ? 31.43027  0.32905   -23.58020 1.000 15.15611  ?  270 ASN A ND2  1 
ATOM   3020 H H    A ASN A 1 189 ? 34.04796  -1.75959  -25.72216 0.850 16.49266  ?  270 ASN A H    1 
ATOM   3021 D D    B ASN A 1 189 ? 34.04839  -1.75938  -25.72260 0.150 16.49266  ?  270 ASN A D    1 
ATOM   3022 H HA   . ASN A 1 189 ? 34.91767  -1.56124  -22.92630 1.000 17.95734  ?  270 ASN A HA   1 
ATOM   3023 H HB2  . ASN A 1 189 ? 32.23425  -2.03739  -24.26347 1.000 17.27221  ?  270 ASN A HB2  1 
ATOM   3024 H HB3  . ASN A 1 189 ? 32.49162  -2.06934  -22.49666 1.000 17.27221  ?  270 ASN A HB3  1 
ATOM   3025 H HD21 A ASN A 1 189 ? 30.65816  -0.31520  -23.75106 0.000 18.18733  ?  270 ASN A HD21 1 
ATOM   3026 D DD21 B ASN A 1 189 ? 30.65816  -0.31520  -23.75106 1.000 18.18733  ?  270 ASN A DD21 1 
ATOM   3027 H HD22 A ASN A 1 189 ? 31.25953  1.33433   -23.55456 0.090 18.18733  ?  270 ASN A HD22 1 
ATOM   3028 D DD22 B ASN A 1 189 ? 31.25953  1.33433   -23.55456 0.910 18.18733  ?  270 ASN A DD22 1 
ATOM   3029 N N    . LEU A 1 190 ? 34.70066  -4.34661  -24.46775 1.000 14.13579  ?  271 LEU A N    1 
ATOM   3030 C CA   . LEU A 1 190 ? 34.67497  -5.80622  -24.35071 1.000 13.95408  ?  271 LEU A CA   1 
ATOM   3031 C C    . LEU A 1 190 ? 35.73265  -6.32385  -23.39998 1.000 16.25778  ?  271 LEU A C    1 
ATOM   3032 O O    . LEU A 1 190 ? 35.44388  -7.15032  -22.53146 1.000 16.71734  ?  271 LEU A O    1 
ATOM   3033 C CB   . LEU A 1 190 ? 34.84042  -6.46041  -25.71342 1.000 14.92435  ?  271 LEU A CB   1 
ATOM   3034 C CG   . LEU A 1 190 ? 33.66534  -6.32189  -26.65341 1.000 17.00404  ?  271 LEU A CG   1 
ATOM   3035 C CD1  . LEU A 1 190 ? 34.04024  -6.78884  -28.06404 1.000 19.18814  ?  271 LEU A CD1  1 
ATOM   3036 C CD2  . LEU A 1 190 ? 32.48209  -7.10266  -26.21125 1.000 18.17983  ?  271 LEU A CD2  1 
ATOM   3037 H H    A LEU A 1 190 ? 34.95481  -4.00399  -25.39426 1.000 16.96294  ?  271 LEU A H    1 
ATOM   3038 D D    B LEU A 1 190 ? 34.95503  -4.00625  -25.39503 0.000 16.96294  ?  271 LEU A D    1 
ATOM   3039 H HA   . LEU A 1 190 ? 33.69807  -6.07931  -23.95173 1.000 16.74490  ?  271 LEU A HA   1 
ATOM   3040 H HB2  . LEU A 1 190 ? 35.70351  -6.01141  -26.20492 1.000 17.90922  ?  271 LEU A HB2  1 
ATOM   3041 H HB3  . LEU A 1 190 ? 35.01047  -7.52634  -25.56180 1.000 17.90922  ?  271 LEU A HB3  1 
ATOM   3042 H HG   . LEU A 1 190 ? 33.39819  -5.26515  -26.65984 1.000 20.40484  ?  271 LEU A HG   1 
ATOM   3043 H HD11 . LEU A 1 190 ? 33.12976  -6.91396  -28.65012 1.000 23.02577  ?  271 LEU A HD11 1 
ATOM   3044 H HD12 . LEU A 1 190 ? 34.68061  -6.03851  -28.52775 1.000 23.02577  ?  271 LEU A HD12 1 
ATOM   3045 H HD13 . LEU A 1 190 ? 34.57077  -7.73845  -27.99422 1.000 23.02577  ?  271 LEU A HD13 1 
ATOM   3046 H HD21 . LEU A 1 190 ? 32.76651  -8.14975  -26.10727 1.000 21.81579  ?  271 LEU A HD21 1 
ATOM   3047 H HD22 . LEU A 1 190 ? 32.13839  -6.71390  -25.25270 1.000 21.81579  ?  271 LEU A HD22 1 
ATOM   3048 H HD23 . LEU A 1 190 ? 31.69308  -7.00409  -26.95681 1.000 21.81579  ?  271 LEU A HD23 1 
ATOM   3049 N N    . SER A 1 191 ? 36.97571  -5.86610  -23.53495 1.000 17.22775  ?  272 SER A N    1 
ATOM   3050 C CA   . SER A 1 191 ? 38.04469  -6.39617  -22.68580 1.000 16.47390  ?  272 SER A CA   1 
ATOM   3051 C C    . SER A 1 191 ? 37.87996  -5.97307  -21.23964 1.000 18.48365  ?  272 SER A C    1 
ATOM   3052 O O    . SER A 1 191 ? 38.01629  -6.83235  -20.34035 1.000 17.84225  ?  272 SER A O    1 
ATOM   3053 C CB   . SER A 1 191 ? 39.41604  -6.05097  -23.29423 1.000 29.43938  ?  272 SER A CB   1 
ATOM   3054 O OG   . SER A 1 191 ? 40.48606  -6.52394  -22.47916 1.000 38.38785  ?  272 SER A OG   1 
ATOM   3055 H H    A SER A 1 191 ? 37.27038  -5.15140  -24.20037 0.000 20.67330  ?  272 SER A H    1 
ATOM   3056 D D    B SER A 1 191 ? 37.27378  -5.15167  -24.19914 1.000 20.67330  ?  272 SER A D    1 
ATOM   3057 H HA   . SER A 1 191 ? 37.98349  -7.48445  -22.68581 1.000 19.76868  ?  272 SER A HA   1 
ATOM   3058 H HB2  . SER A 1 191 ? 39.49130  -6.51563  -24.27735 1.000 35.32725  ?  272 SER A HB2  1 
ATOM   3059 H HB3  . SER A 1 191 ? 39.49690  -4.96790  -23.38661 1.000 35.32725  ?  272 SER A HB3  1 
ATOM   3060 N N    . PRO A 1 192 ? 37.59471  -4.71194  -20.92289 1.000 16.33973  ?  273 PRO A N    1 
ATOM   3061 C CA   . PRO A 1 192 ? 37.32030  -4.37167  -19.52743 1.000 18.22485  ?  273 PRO A CA   1 
ATOM   3062 C C    . PRO A 1 192 ? 36.15808  -5.17884  -18.95142 1.000 15.89077  ?  273 PRO A C    1 
ATOM   3063 O O    . PRO A 1 192 ? 36.21968  -5.58056  -17.78542 1.000 17.21081  ?  273 PRO A O    1 
ATOM   3064 C CB   . PRO A 1 192 ? 37.01877  -2.86167  -19.56412 1.000 18.79148  ?  273 PRO A CB   1 
ATOM   3065 C CG   . PRO A 1 192 ? 37.57747  -2.39163  -20.79832 1.000 24.32956  ?  273 PRO A CG   1 
ATOM   3066 C CD   . PRO A 1 192 ? 37.64985  -3.51317  -21.78808 1.000 16.16583  ?  273 PRO A CD   1 
ATOM   3067 H HA   . PRO A 1 192 ? 38.21488  -4.52475  -18.92379 1.000 21.86982  ?  273 PRO A HA   1 
ATOM   3068 H HB2  . PRO A 1 192 ? 35.94117  -2.69970  -19.53894 1.000 22.54978  ?  273 PRO A HB2  1 
ATOM   3069 H HB3  . PRO A 1 192 ? 37.48960  -2.37043  -18.71259 1.000 22.54978  ?  273 PRO A HB3  1 
ATOM   3070 H HG2  . PRO A 1 192 ? 36.94178  -1.59652  -21.18794 1.000 29.19548  ?  273 PRO A HG2  1 
ATOM   3071 H HG3  . PRO A 1 192 ? 38.57847  -2.00684  -20.60331 1.000 29.19548  ?  273 PRO A HG3  1 
ATOM   3072 H HD2  . PRO A 1 192 ? 36.80190  -3.48579  -22.47243 1.000 19.39900  ?  273 PRO A HD2  1 
ATOM   3073 H HD3  . PRO A 1 192 ? 38.58342  -3.47914  -22.34969 1.000 19.39900  ?  273 PRO A HD3  1 
ATOM   3074 N N    . ALA A 1 193 ? 35.10608  -5.42766  -19.72982 1.000 14.74967  ?  274 ALA A N    1 
ATOM   3075 C CA   . ALA A 1 193 ? 34.00092  -6.24710  -19.22974 1.000 13.53484  ?  274 ALA A CA   1 
ATOM   3076 C C    . ALA A 1 193 ? 34.47045  -7.66279  -18.93851 1.000 14.97578  ?  274 ALA A C    1 
ATOM   3077 O O    . ALA A 1 193 ? 34.17652  -8.22111  -17.86764 1.000 14.75527  ?  274 ALA A O    1 
ATOM   3078 C CB   . ALA A 1 193 ? 32.84339  -6.23739  -20.23129 1.000 14.82361  ?  274 ALA A CB   1 
ATOM   3079 H H    A ALA A 1 193 ? 34.98969  -5.08746  -20.68434 0.820 17.69960  ?  274 ALA A H    1 
ATOM   3080 D D    B ALA A 1 193 ? 34.98761  -5.08855  -20.68447 0.180 17.69960  ?  274 ALA A D    1 
ATOM   3081 H HA   . ALA A 1 193 ? 33.62928  -5.81972  -18.29843 1.000 16.24181  ?  274 ALA A HA   1 
ATOM   3082 H HB1  . ALA A 1 193 ? 31.90601  -6.37210  -19.69159 1.000 17.78833  ?  274 ALA A HB1  1 
ATOM   3083 H HB2  . ALA A 1 193 ? 32.83618  -5.28205  -20.75606 1.000 17.78833  ?  274 ALA A HB2  1 
ATOM   3084 H HB3  . ALA A 1 193 ? 32.98292  -7.05126  -20.94280 1.000 17.78833  ?  274 ALA A HB3  1 
ATOM   3085 N N    . ALA A 1 194 ? 35.20710  -8.27817  -19.87378 1.000 14.62224  ?  275 ALA A N    1 
ATOM   3086 C CA   . ALA A 1 194 ? 35.63735  -9.66814  -19.66617 1.000 15.33395  ?  275 ALA A CA   1 
ATOM   3087 C C    . ALA A 1 194 ? 36.54981  -9.76716  -18.46253 1.000 15.07789  ?  275 ALA A C    1 
ATOM   3088 O O    . ALA A 1 194 ? 36.45166  -10.71143 -17.67542 1.000 17.98912  ?  275 ALA A O    1 
ATOM   3089 C CB   . ALA A 1 194 ? 36.35492  -10.17954 -20.90786 1.000 16.28855  ?  275 ALA A CB   1 
ATOM   3090 H H    A ALA A 1 194 ? 35.51138  -7.85917  -20.75256 1.000 17.54669  ?  275 ALA A H    1 
ATOM   3091 D D    B ALA A 1 194 ? 35.51261  -7.86143  -20.75321 0.000 17.54669  ?  275 ALA A D    1 
ATOM   3092 H HA   . ALA A 1 194 ? 34.76066  -10.29300 -19.49565 1.000 18.40074  ?  275 ALA A HA   1 
ATOM   3093 H HB1  . ALA A 1 194 ? 37.39054  -9.84039  -20.88420 1.000 19.54626  ?  275 ALA A HB1  1 
ATOM   3094 H HB2  . ALA A 1 194 ? 36.32063  -11.26898 -20.91413 1.000 19.54626  ?  275 ALA A HB2  1 
ATOM   3095 H HB3  . ALA A 1 194 ? 35.85532  -9.78683  -21.79346 1.000 19.54626  ?  275 ALA A HB3  1 
ATOM   3096 N N    . GLN A 1 195 ? 37.39285  -8.77085  -18.24679 1.000 15.54319  ?  276 GLN A N    1 
ATOM   3097 C CA   . GLN A 1 195 ? 38.27890  -8.80129  -17.08656 1.000 17.08597  ?  276 GLN A CA   1 
ATOM   3098 C C    . GLN A 1 195 ? 37.46279  -8.75270  -15.79528 1.000 18.77073  ?  276 GLN A C    1 
ATOM   3099 O O    . GLN A 1 195 ? 37.75288  -9.47753  -14.83306 1.000 19.03790  ?  276 GLN A O    1 
ATOM   3100 C CB   . GLN A 1 195 ? 39.25216  -7.62546  -17.12553 1.000 19.82250  ?  276 GLN A CB   1 
ATOM   3101 C CG   . GLN A 1 195 ? 40.38700  -7.74737  -18.15955 1.000 45.34769  ?  276 GLN A CG   1 
ATOM   3102 C CD   . GLN A 1 195 ? 41.18302  -6.43214  -18.27983 1.000 70.08850  ?  276 GLN A CD   1 
ATOM   3103 O OE1  . GLN A 1 195 ? 41.74292  -5.94580  -17.28992 1.000 54.51096  ?  276 GLN A OE1  1 
ATOM   3104 N NE2  . GLN A 1 195 ? 41.20021  -5.83810  -19.48358 1.000 39.04999  ?  276 GLN A NE2  1 
ATOM   3105 H H    A GLN A 1 195 ? 37.48927  -7.94554  -18.83836 0.990 18.65183  ?  276 GLN A H    1 
ATOM   3106 D D    B GLN A 1 195 ? 37.49116  -7.94461  -18.83676 0.010 18.65183  ?  276 GLN A D    1 
ATOM   3107 H HA   . GLN A 1 195 ? 38.86195  -9.72186  -17.11297 1.000 20.50316  ?  276 GLN A HA   1 
ATOM   3108 H HB2  . GLN A 1 195 ? 38.69072  -6.72186  -17.36297 1.000 23.78700  ?  276 GLN A HB2  1 
ATOM   3109 H HB3  . GLN A 1 195 ? 39.71517  -7.52941  -16.14344 1.000 23.78700  ?  276 GLN A HB3  1 
ATOM   3110 H HG2  . GLN A 1 195 ? 41.07264  -8.53678  -17.85161 1.000 54.41722  ?  276 GLN A HG2  1 
ATOM   3111 H HG3  . GLN A 1 195 ? 39.96232  -7.98219  -19.13557 1.000 54.41722  ?  276 GLN A HG3  1 
ATOM   3112 N N    . LEU A 1 196 ? 36.43055  -7.89673  -15.74874 1.000 15.12623  ?  277 LEU A N    1 
ATOM   3113 C CA   . LEU A 1 196 ? 35.62282  -7.78967  -14.54037 1.000 15.35301  ?  277 LEU A CA   1 
ATOM   3114 C C    . LEU A 1 196 ? 34.85467  -9.07020  -14.27364 1.000 14.03602  ?  277 LEU A C    1 
ATOM   3115 O O    . LEU A 1 196 ? 34.87839  -9.58219  -13.14762 1.000 14.41072  ?  277 LEU A O    1 
ATOM   3116 C CB   . LEU A 1 196 ? 34.65814  -6.60753  -14.68584 1.000 16.25733  ?  277 LEU A CB   1 
ATOM   3117 C CG   . LEU A 1 196 ? 33.73125  -6.41817  -13.48872 1.000 18.54147  ?  277 LEU A CG   1 
ATOM   3118 C CD1  . LEU A 1 196 ? 34.43963  -6.02192  -12.25637 1.000 31.16458  ?  277 LEU A CD1  1 
ATOM   3119 C CD2  . LEU A 1 196 ? 32.69315  -5.36117  -13.85185 1.000 25.16299  ?  277 LEU A CD2  1 
ATOM   3120 H H    A LEU A 1 196 ? 36.14212  -7.28477  -16.51209 0.930 18.15148  ?  277 LEU A H    1 
ATOM   3121 D D    B LEU A 1 196 ? 36.14037  -7.28393  -16.51075 0.070 18.15148  ?  277 LEU A D    1 
ATOM   3122 H HA   . LEU A 1 196 ? 36.27691  -7.61115  -13.68691 1.000 18.42361  ?  277 LEU A HA   1 
ATOM   3123 H HB2  . LEU A 1 196 ? 35.24050  -5.69378  -14.80426 1.000 19.50880  ?  277 LEU A HB2  1 
ATOM   3124 H HB3  . LEU A 1 196 ? 34.03645  -6.77012  -15.56627 1.000 19.50880  ?  277 LEU A HB3  1 
ATOM   3125 H HG   . LEU A 1 196 ? 33.25864  -7.37459  -13.26510 1.000 22.24976  ?  277 LEU A HG   1 
ATOM   3126 H HD11 . LEU A 1 196 ? 35.28551  -5.38769  -12.52160 1.000 37.39749  ?  277 LEU A HD11 1 
ATOM   3127 H HD12 . LEU A 1 196 ? 33.75185  -5.47405  -11.61225 1.000 37.39749  ?  277 LEU A HD12 1 
ATOM   3128 H HD13 . LEU A 1 196 ? 34.79261  -6.91813  -11.74617 1.000 37.39749  ?  277 LEU A HD13 1 
ATOM   3129 H HD21 . LEU A 1 196 ? 31.95151  -5.80548  -14.51567 1.000 30.19559  ?  277 LEU A HD21 1 
ATOM   3130 H HD22 . LEU A 1 196 ? 32.21174  -5.00849  -12.93973 1.000 30.19559  ?  277 LEU A HD22 1 
ATOM   3131 H HD23 . LEU A 1 196 ? 33.19167  -4.53181  -14.35359 1.000 30.19559  ?  277 LEU A HD23 1 
ATOM   3132 N N    . PHE A 1 197 ? 34.16782  -9.59410  -15.27426 1.000 12.87002  ?  278 PHE A N    1 
ATOM   3133 C CA   . PHE A 1 197 ? 33.35967  -10.79043 -15.05192 1.000 13.10711  ?  278 PHE A CA   1 
ATOM   3134 C C    . PHE A 1 197 ? 34.21481  -11.97691 -14.65412 1.000 14.58519  ?  278 PHE A C    1 
ATOM   3135 O O    . PHE A 1 197 ? 33.83806  -12.74967 -13.76517 1.000 14.51867  ?  278 PHE A O    1 
ATOM   3136 C CB   . PHE A 1 197 ? 32.48550  -11.10660 -16.26804 1.000 15.23299  ?  278 PHE A CB   1 
ATOM   3137 C CG   . PHE A 1 197 ? 31.38695  -10.09898 -16.45199 1.000 17.99577  ?  278 PHE A CG   1 
ATOM   3138 C CD1  . PHE A 1 197 ? 30.44773  -9.89733  -15.43478 1.000 20.73054  ?  278 PHE A CD1  1 
ATOM   3139 C CD2  . PHE A 1 197 ? 31.28813  -9.36377  -17.60640 1.000 22.54952  ?  278 PHE A CD2  1 
ATOM   3140 C CE1  . PHE A 1 197 ? 29.43559  -8.93367  -15.57268 1.000 25.76164  ?  278 PHE A CE1  1 
ATOM   3141 C CE2  . PHE A 1 197 ? 30.27409  -8.39681  -17.73850 1.000 20.91788  ?  278 PHE A CE2  1 
ATOM   3142 C CZ   . PHE A 1 197 ? 29.38477  -8.18985  -16.70454 1.000 23.77322  ?  278 PHE A CZ   1 
ATOM   3143 H H    A PHE A 1 197 ? 34.14571  -9.22973  -16.22670 1.000 15.44403  ?  278 PHE A H    1 
ATOM   3144 D D    B PHE A 1 197 ? 34.14406  -9.23168  -16.22740 0.000 15.44403  ?  278 PHE A D    1 
ATOM   3145 H HA   . PHE A 1 197 ? 32.67795  -10.58772 -14.22593 1.000 15.72853  ?  278 PHE A HA   1 
ATOM   3146 H HB2  . PHE A 1 197 ? 33.10521  -11.10225 -17.16473 1.000 18.27958  ?  278 PHE A HB2  1 
ATOM   3147 H HB3  . PHE A 1 197 ? 32.02910  -12.08748 -16.13505 1.000 18.27958  ?  278 PHE A HB3  1 
ATOM   3148 H HD1  . PHE A 1 197 ? 30.50174  -10.48955 -14.53325 1.000 24.87664  ?  278 PHE A HD1  1 
ATOM   3149 H HD2  . PHE A 1 197 ? 31.98778  -9.52699  -18.41278 1.000 27.05942  ?  278 PHE A HD2  1 
ATOM   3150 H HE1  . PHE A 1 197 ? 28.70808  -8.78735  -14.78800 1.000 30.91397  ?  278 PHE A HE1  1 
ATOM   3151 H HE2  . PHE A 1 197 ? 30.19245  -7.81840  -18.64689 1.000 25.10146  ?  278 PHE A HE2  1 
ATOM   3152 H HZ   . PHE A 1 197 ? 28.63322  -7.41999  -16.79878 1.000 28.52786  ?  278 PHE A HZ   1 
ATOM   3153 N N    . THR A 1 198 ? 35.38357  -12.12296 -15.27476 1.000 14.93405  ?  279 THR A N    1 
ATOM   3154 C CA   . THR A 1 198 ? 36.29316  -13.20259 -14.92323 1.000 15.02835  ?  279 THR A CA   1 
ATOM   3155 C C    . THR A 1 198 ? 36.79532  -13.06194 -13.49738 1.000 16.62676  ?  279 THR A C    1 
ATOM   3156 O O    . THR A 1 198 ? 36.91082  -14.07541 -12.78196 1.000 17.57065  ?  279 THR A O    1 
ATOM   3157 C CB   . THR A 1 198 ? 37.46153  -13.21237 -15.92604 1.000 18.84233  ?  279 THR A CB   1 
ATOM   3158 O OG1  . THR A 1 198 ? 36.94043  -13.54305 -17.22365 1.000 25.01523  ?  279 THR A OG1  1 
ATOM   3159 C CG2  . THR A 1 198 ? 38.48818  -14.24845 -15.54157 1.000 35.54831  ?  279 THR A CG2  1 
ATOM   3160 H H    A THR A 1 198 ? 35.72525  -11.51455 -16.01873 0.990 17.92086  ?  279 THR A H    1 
ATOM   3161 D D    B THR A 1 198 ? 35.72751  -11.51603 -16.01890 0.010 17.92086  ?  279 THR A D    1 
ATOM   3162 H HA   . THR A 1 198 ? 35.77297  -14.15835 -14.98665 1.000 18.03402  ?  279 THR A HA   1 
ATOM   3163 H HB   . THR A 1 198 ? 37.94733  -12.23671 -15.93930 1.000 22.61080  ?  279 THR A HB   1 
ATOM   3164 H HG1  A THR A 1 198 ? 36.51898  -12.75524 -17.62633 0.080 30.01828  ?  279 THR A HG1  1 
ATOM   3165 D DG1  B THR A 1 198 ? 36.53390  -12.75105 -17.63338 0.920 30.01828  ?  279 THR A DG1  1 
ATOM   3166 H HG21 . THR A 1 198 ? 38.77649  -14.11844 -14.49847 1.000 42.65797  ?  279 THR A HG21 1 
ATOM   3167 H HG22 . THR A 1 198 ? 38.07543  -15.24876 -15.67245 1.000 42.65797  ?  279 THR A HG22 1 
ATOM   3168 H HG23 . THR A 1 198 ? 39.37381  -14.14637 -16.16873 1.000 42.65797  ?  279 THR A HG23 1 
ATOM   3169 N N    . GLN A 1 199 ? 37.11249  -11.83419 -13.06047 1.000 14.90189  ?  280 GLN A N    1 
ATOM   3170 C CA   A GLN A 1 199 ? 37.54976  -11.67824 -11.68001 0.490 15.99390  ?  280 GLN A CA   1 
ATOM   3171 C CA   B GLN A 1 199 ? 37.52676  -11.60289 -11.67674 0.510 15.93349  ?  280 GLN A CA   1 
ATOM   3172 C C    . GLN A 1 199 ? 36.44406  -12.04874 -10.70734 1.000 16.48461  ?  280 GLN A C    1 
ATOM   3173 O O    . GLN A 1 199 ? 36.71958  -12.65016 -9.66734  1.000 17.28624  ?  280 GLN A O    1 
ATOM   3174 C CB   A GLN A 1 199 ? 38.07733  -10.27262 -11.39021 0.490 19.41969  ?  280 GLN A CB   1 
ATOM   3175 C CB   B GLN A 1 199 ? 37.84493  -10.10578 -11.50629 0.510 19.63684  ?  280 GLN A CB   1 
ATOM   3176 C CG   A GLN A 1 199 ? 38.73038  -10.14367 -10.00017 0.490 25.54905  ?  280 GLN A CG   1 
ATOM   3177 C CG   B GLN A 1 199 ? 37.78152  -9.51454  -10.10400 0.510 24.94807  ?  280 GLN A CG   1 
ATOM   3178 C CD   A GLN A 1 199 ? 39.86297  -11.14231 -9.75385  0.490 37.82409  ?  280 GLN A CD   1 
ATOM   3179 C CD   B GLN A 1 199 ? 37.91697  -7.98172  -10.11122 0.510 37.98023  ?  280 GLN A CD   1 
ATOM   3180 O OE1  A GLN A 1 199 ? 39.95170  -11.74204 -8.67833  0.490 32.77416  ?  280 GLN A OE1  1 
ATOM   3181 O OE1  B GLN A 1 199 ? 38.82129  -7.42163  -10.74267 0.510 38.08328  ?  280 GLN A OE1  1 
ATOM   3182 N NE2  A GLN A 1 199 ? 40.73067  -11.32118 -10.75047 0.490 38.48481  ?  280 GLN A NE2  1 
ATOM   3183 N NE2  B GLN A 1 199 ? 37.01280  -7.30406  -9.40394  0.510 28.32964  ?  280 GLN A NE2  1 
ATOM   3184 H H    A GLN A 1 199 ? 37.07672  -10.97787 -13.61348 0.490 17.88227  ?  280 GLN A H    1 
ATOM   3185 H H    B GLN A 1 199 ? 37.09194  -10.99170 -13.63508 0.510 17.88227  ?  280 GLN A H    1 
ATOM   3186 H HA   A GLN A 1 199 ? 38.39051  -12.35553 -11.52995 0.490 19.19269  ?  280 GLN A HA   1 
ATOM   3187 H HA   B GLN A 1 199 ? 38.42472  -12.17698 -11.44828 0.510 19.12018  ?  280 GLN A HA   1 
ATOM   3188 H HB2  A GLN A 1 199 ? 38.82747  -10.01619 -12.13830 0.490 23.30363  ?  280 GLN A HB2  1 
ATOM   3189 H HB2  B GLN A 1 199 ? 38.85907  -9.93910  -11.86938 0.510 23.56420  ?  280 GLN A HB2  1 
ATOM   3190 H HB3  A GLN A 1 199 ? 37.24738  -9.56761  -11.43758 0.490 23.30363  ?  280 GLN A HB3  1 
ATOM   3191 H HB3  B GLN A 1 199 ? 37.13460  -9.54480  -12.11360 0.510 23.56420  ?  280 GLN A HB3  1 
ATOM   3192 H HG2  A GLN A 1 199 ? 39.14467  -9.14054  -9.89927  0.490 30.65886  ?  280 GLN A HG2  1 
ATOM   3193 H HG2  B GLN A 1 199 ? 36.82266  -9.76846  -9.65212  0.510 29.93768  ?  280 GLN A HG2  1 
ATOM   3194 H HG3  A GLN A 1 199 ? 37.96897  -10.31093 -9.23834  0.490 30.65886  ?  280 GLN A HG3  1 
ATOM   3195 H HG3  B GLN A 1 199 ? 38.59559  -9.92444  -9.50618  0.510 29.93768  ?  280 GLN A HG3  1 
ATOM   3196 H HE21 A GLN A 1 199 ? 40.61949  -10.80385 -11.62248 0.490 46.18177  ?  280 GLN A HE21 1 
ATOM   3197 H HE21 B GLN A 1 199 ? 36.28305  -7.80428  -8.89636  0.510 33.99557  ?  280 GLN A HE21 1 
ATOM   3198 H HE22 A GLN A 1 199 ? 41.50556  -11.97532 -10.64078 0.490 46.18177  ?  280 GLN A HE22 1 
ATOM   3199 H HE22 B GLN A 1 199 ? 37.05071  -6.28532  -9.37033  0.510 33.99557  ?  280 GLN A HE22 1 
ATOM   3200 N N    . VAL A 1 200 ? 35.18843  -11.72944 -11.02534 1.000 14.86799  ?  281 VAL A N    1 
ATOM   3201 C CA   . VAL A 1 200 ? 34.09091  -12.07839 -10.13660 1.000 14.47208  ?  281 VAL A CA   1 
ATOM   3202 C C    . VAL A 1 200 ? 33.92287  -13.58930 -10.05864 1.000 12.94204  ?  281 VAL A C    1 
ATOM   3203 O O    . VAL A 1 200 ? 33.75159  -14.16381 -8.97197  1.000 13.65935  ?  281 VAL A O    1 
ATOM   3204 C CB   . VAL A 1 200 ? 32.82100  -11.33824 -10.61644 1.000 14.88583  ?  281 VAL A CB   1 
ATOM   3205 C CG1  . VAL A 1 200 ? 31.56502  -11.88775 -9.91285  1.000 15.07740  ?  281 VAL A CG1  1 
ATOM   3206 C CG2  . VAL A 1 200 ? 32.96118  -9.85101  -10.38981 1.000 17.41813  ?  281 VAL A CG2  1 
ATOM   3207 H H    A VAL A 1 200 ? 34.90784  -11.23917 -11.87463 0.900 17.84159  ?  281 VAL A H    1 
ATOM   3208 D D    B VAL A 1 200 ? 34.90553  -11.23927 -11.87393 0.100 17.84159  ?  281 VAL A D    1 
ATOM   3209 H HA   . VAL A 1 200 ? 34.30653  -11.75203 -9.11921  1.000 17.36650  ?  281 VAL A HA   1 
ATOM   3210 H HB   . VAL A 1 200 ? 32.69922  -11.50791 -11.68624 1.000 17.86300  ?  281 VAL A HB   1 
ATOM   3211 H HG11 . VAL A 1 200 ? 30.68424  -11.39151 -10.32038 1.000 18.09288  ?  281 VAL A HG11 1 
ATOM   3212 H HG12 . VAL A 1 200 ? 31.50117  -12.96163 -10.08834 1.000 18.09288  ?  281 VAL A HG12 1 
ATOM   3213 H HG13 . VAL A 1 200 ? 31.64191  -11.68974 -8.84375  1.000 18.09288  ?  281 VAL A HG13 1 
ATOM   3214 H HG21 . VAL A 1 200 ? 32.89124  -9.64671  -9.32142  1.000 20.90175  ?  281 VAL A HG21 1 
ATOM   3215 H HG22 . VAL A 1 200 ? 33.92976  -9.52414  -10.76812 1.000 20.90175  ?  281 VAL A HG22 1 
ATOM   3216 H HG23 . VAL A 1 200 ? 32.16133  -9.33428  -10.92020 1.000 20.90175  ?  281 VAL A HG23 1 
ATOM   3217 N N    . TRP A 1 201 ? 33.98628  -14.25240 -11.19943 1.000 12.22565  ?  282 TRP A N    1 
ATOM   3218 C CA   . TRP A 1 201 ? 33.92500  -15.70376 -11.24322 1.000 13.71605  ?  282 TRP A CA   1 
ATOM   3219 C C    . TRP A 1 201 ? 35.05891  -16.32409 -10.43857 1.000 14.85799  ?  282 TRP A C    1 
ATOM   3220 O O    . TRP A 1 201 ? 34.83608  -17.27887 -9.69681  1.000 15.96298  ?  282 TRP A O    1 
ATOM   3221 C CB   . TRP A 1 201 ? 33.98303  -16.11002 -12.71028 1.000 15.64341  ?  282 TRP A CB   1 
ATOM   3222 C CG   . TRP A 1 201 ? 34.16992  -17.54185 -13.07035 1.000 14.37702  ?  282 TRP A CG   1 
ATOM   3223 C CD1  . TRP A 1 201 ? 33.26027  -18.52870 -13.00049 1.000 14.90266  ?  282 TRP A CD1  1 
ATOM   3224 C CD2  . TRP A 1 201 ? 35.35224  -18.12607 -13.61055 1.000 15.86088  ?  282 TRP A CD2  1 
ATOM   3225 N NE1  . TRP A 1 201 ? 33.78575  -19.71158 -13.47148 1.000 17.05633  ?  282 TRP A NE1  1 
ATOM   3226 C CE2  . TRP A 1 201 ? 35.08019  -19.47664 -13.84718 1.000 18.11753  ?  282 TRP A CE2  1 
ATOM   3227 C CE3  . TRP A 1 201 ? 36.62391  -17.61485 -13.94788 1.000 17.54603  ?  282 TRP A CE3  1 
ATOM   3228 C CZ2  . TRP A 1 201 ? 36.04359  -20.35410 -14.39407 1.000 17.84802  ?  282 TRP A CZ2  1 
ATOM   3229 C CZ3  . TRP A 1 201 ? 37.58014  -18.50359 -14.49832 1.000 21.39107  ?  282 TRP A CZ3  1 
ATOM   3230 C CH2  . TRP A 1 201 ? 37.26869  -19.83211 -14.72027 1.000 20.77327  ?  282 TRP A CH2  1 
ATOM   3231 H H    A TRP A 1 201 ? 34.08058  -13.81560 -12.11634 1.000 14.67078  ?  282 TRP A H    1 
ATOM   3232 D D    B TRP A 1 201 ? 34.08056  -13.81808 -12.11752 0.000 14.67078  ?  282 TRP A D    1 
ATOM   3233 H HA   . TRP A 1 201 ? 32.99904  -16.07537 -10.80437 1.000 16.45926  ?  282 TRP A HA   1 
ATOM   3234 H HB2  . TRP A 1 201 ? 33.04431  -15.80104 -13.17010 1.000 18.77210  ?  282 TRP A HB2  1 
ATOM   3235 H HB3  . TRP A 1 201 ? 34.81524  -15.57151 -13.16362 1.000 18.77210  ?  282 TRP A HB3  1 
ATOM   3236 H HD1  . TRP A 1 201 ? 32.25420  -18.41035 -12.62603 1.000 17.88319  ?  282 TRP A HD1  1 
ATOM   3237 H HE3  . TRP A 1 201 ? 36.86182  -16.57321 -13.79047 1.000 21.05523  ?  282 TRP A HE3  1 
ATOM   3238 H HZ2  . TRP A 1 201 ? 35.82245  -21.39970 -14.54968 1.000 21.41762  ?  282 TRP A HZ2  1 
ATOM   3239 H HZ3  . TRP A 1 201 ? 38.56542  -18.13839 -14.74784 1.000 25.66928  ?  282 TRP A HZ3  1 
ATOM   3240 H HH2  . TRP A 1 201 ? 38.01230  -20.47776 -15.16365 1.000 24.92793  ?  282 TRP A HH2  1 
ATOM   3241 N N    . GLN A 1 202 ? 36.27627  -15.80891 -10.56938 1.000 14.56217  ?  283 GLN A N    1 
ATOM   3242 C CA   . GLN A 1 202 ? 37.41177  -16.34700 -9.81234  1.000 16.47434  ?  283 GLN A CA   1 
ATOM   3243 C C    . GLN A 1 202 ? 37.21783  -16.14022 -8.32063  1.000 16.81235  ?  283 GLN A C    1 
ATOM   3244 O O    . GLN A 1 202 ? 37.47040  -17.05073 -7.51846  1.000 17.34583  ?  283 GLN A O    1 
ATOM   3245 C CB   . GLN A 1 202 ? 38.69133  -15.63583 -10.25686 1.000 21.42055  ?  283 GLN A CB   1 
ATOM   3246 C CG   . GLN A 1 202 ? 39.37204  -16.29962 -11.43873 1.000 52.63617  ?  283 GLN A CG   1 
ATOM   3247 C CD   . GLN A 1 202 ? 40.45297  -15.42791 -12.07910 1.000 57.91341  ?  283 GLN A CD   1 
ATOM   3248 O OE1  . GLN A 1 202 ? 40.84676  -14.39644 -11.52412 1.000 48.38499  ?  283 GLN A OE1  1 
ATOM   3249 N NE2  . GLN A 1 202 ? 40.92368  -15.83790 -13.26276 1.000 39.57444  ?  283 GLN A NE2  1 
ATOM   3250 H H    A GLN A 1 202 ? 36.51338  -15.02844 -11.18178 0.900 17.47461  ?  283 GLN A H    1 
ATOM   3251 D D    B GLN A 1 202 ? 36.51567  -15.02858 -11.18107 0.100 17.47461  ?  283 GLN A D    1 
ATOM   3252 H HA   . GLN A 1 202 ? 37.49661  -17.41530 -10.01147 1.000 19.76921  ?  283 GLN A HA   1 
ATOM   3253 H HB2  . GLN A 1 202 ? 38.44388  -14.61399 -10.54444 1.000 25.70466  ?  283 GLN A HB2  1 
ATOM   3254 H HB3  . GLN A 1 202 ? 39.39655  -15.62883 -9.42577  1.000 25.70466  ?  283 GLN A HB3  1 
ATOM   3255 H HG2  . GLN A 1 202 ? 39.84262  -17.22343 -11.10223 1.000 63.16340  ?  283 GLN A HG2  1 
ATOM   3256 H HG3  . GLN A 1 202 ? 38.62356  -16.51843 -12.20031 1.000 63.16340  ?  283 GLN A HG3  1 
ATOM   3257 N N    . ASN A 1 203 ? 36.76844  -14.96088 -7.90265  1.000 15.03795  ?  284 ASN A N    1 
ATOM   3258 C CA   . ASN A 1 203 ? 36.62811  -14.68931 -6.48767  1.000 15.82645  ?  284 ASN A CA   1 
ATOM   3259 C C    . ASN A 1 203 ? 35.58762  -15.57409 -5.84811  1.000 17.52034  ?  284 ASN A C    1 
ATOM   3260 O O    . ASN A 1 203 ? 35.67085  -15.87994 -4.64944  1.000 16.97932  ?  284 ASN A O    1 
ATOM   3261 C CB   . ASN A 1 203 ? 36.34624  -13.21100 -6.20696  1.000 19.39781  ?  284 ASN A CB   1 
ATOM   3262 C CG   . ASN A 1 203 ? 37.62019  -12.36917 -6.17470  1.000 36.56462  ?  284 ASN A CG   1 
ATOM   3263 O OD1  . ASN A 1 203 ? 38.68314  -12.84920 -5.78666  1.000 44.52936  ?  284 ASN A OD1  1 
ATOM   3264 N ND2  . ASN A 1 203 ? 37.51237  -11.10673 -6.58945  1.000 39.25976  ?  284 ASN A ND2  1 
ATOM   3265 H H    A ASN A 1 203 ? 36.49892  -14.18881 -8.51229  0.970 18.04554  ?  284 ASN A H    1 
ATOM   3266 D D    B ASN A 1 203 ? 36.49831  -14.18732 -8.51013  0.030 18.04554  ?  284 ASN A D    1 
ATOM   3267 H HA   . ASN A 1 203 ? 37.58780  -14.90390 -6.01753  1.000 18.99174  ?  284 ASN A HA   1 
ATOM   3268 H HB2  . ASN A 1 203 ? 35.69975  -12.81639 -6.99082  1.000 23.27737  ?  284 ASN A HB2  1 
ATOM   3269 H HB3  . ASN A 1 203 ? 35.85567  -13.11952 -5.23791  1.000 23.27737  ?  284 ASN A HB3  1 
ATOM   3270 N N    . ALA A 1 204 ? 34.57760  -15.97937 -6.60218  1.000 14.69687  ?  285 ALA A N    1 
ATOM   3271 C CA   . ALA A 1 204 ? 33.53312  -16.84602 -6.09904  1.000 15.18613  ?  285 ALA A CA   1 
ATOM   3272 C C    . ALA A 1 204 ? 33.90154  -18.31267 -6.17200  1.000 16.17413  ?  285 ALA A C    1 
ATOM   3273 O O    . ALA A 1 204 ? 33.05679  -19.16518 -5.90045  1.000 23.61585  ?  285 ALA A O    1 
ATOM   3274 C CB   . ALA A 1 204 ? 32.22834  -16.59706 -6.86912  1.000 15.98257  ?  285 ALA A CB   1 
ATOM   3275 H H    A ALA A 1 204 ? 34.45653  -15.71814 -7.58070  1.000 17.63624  ?  285 ALA A H    1 
ATOM   3276 D D    B ALA A 1 204 ? 34.45759  -15.71745 -7.58065  0.000 17.63624  ?  285 ALA A D    1 
ATOM   3277 H HA   . ALA A 1 204 ? 33.35101  -16.60429 -5.05190  1.000 18.22335  ?  285 ALA A HA   1 
ATOM   3278 H HB1  . ALA A 1 204 ? 32.40929  -16.75077 -7.93295  1.000 19.17909  ?  285 ALA A HB1  1 
ATOM   3279 H HB2  . ALA A 1 204 ? 31.46937  -17.29542 -6.51648  1.000 19.17909  ?  285 ALA A HB2  1 
ATOM   3280 H HB3  . ALA A 1 204 ? 31.90166  -15.57238 -6.69190  1.000 19.17909  ?  285 ALA A HB3  1 
ATOM   3281 N N    . GLY A 1 205 ? 35.11395  -18.65156 -6.58436  1.000 13.95517  ?  286 GLY A N    1 
ATOM   3282 C CA   . GLY A 1 205 ? 35.57925  -20.02673 -6.56926  1.000 15.81265  ?  286 GLY A CA   1 
ATOM   3283 C C    . GLY A 1 205 ? 35.38749  -20.80942 -7.84353  1.000 16.56489  ?  286 GLY A C    1 
ATOM   3284 O O    . GLY A 1 205 ? 35.54738  -22.03815 -7.83454  1.000 17.70058  ?  286 GLY A O    1 
ATOM   3285 H H    A GLY A 1 205 ? 35.80343  -17.98829 -6.93804  0.240 16.74621  ?  286 GLY A H    1 
ATOM   3286 D D    B GLY A 1 205 ? 35.80294  -17.98773 -6.93793  0.760 16.74621  ?  286 GLY A D    1 
ATOM   3287 H HA2  . GLY A 1 205 ? 36.64599  -20.02511 -6.34529  1.000 18.97518  ?  286 GLY A HA2  1 
ATOM   3288 H HA3  . GLY A 1 205 ? 35.05125  -20.55847 -5.77770  1.000 18.97518  ?  286 GLY A HA3  1 
ATOM   3289 N N    . LYS A 1 206 ? 35.03574  -20.15317 -8.94212  1.000 14.87358  ?  287 LYS A N    1 
ATOM   3290 C CA   . LYS A 1 206 ? 34.89315  -20.79970 -10.25336 1.000 14.74402  ?  287 LYS A CA   1 
ATOM   3291 C C    . LYS A 1 206 ? 33.87297  -21.92985 -10.24233 1.000 14.43990  ?  287 LYS A C    1 
ATOM   3292 O O    . LYS A 1 206 ? 34.00225  -22.91152 -10.97340 1.000 17.37878  ?  287 LYS A O    1 
ATOM   3293 C CB   . LYS A 1 206 ? 36.23119  -21.29625 -10.80082 1.000 18.59512  ?  287 LYS A CB   1 
ATOM   3294 C CG   . LYS A 1 206 ? 37.34799  -20.26450 -10.78740 1.000 19.21289  ?  287 LYS A CG   1 
ATOM   3295 C CD   . LYS A 1 206 ? 38.62615  -20.88144 -11.38127 1.000 27.14511  ?  287 LYS A CD   1 
ATOM   3296 C CE   . LYS A 1 206 ? 39.78538  -19.90563 -11.28371 1.000 44.29626  ?  287 LYS A CE   1 
ATOM   3297 N NZ   . LYS A 1 206 ? 41.10081  -20.61193 -11.31956 1.000 40.32154  ?  287 LYS A NZ   1 
ATOM   3298 H H    A LYS A 1 206 ? 34.83726  -19.15291 -8.96425  0.130 17.84830  ?  287 LYS A H    1 
ATOM   3299 D D    B LYS A 1 206 ? 34.83744  -19.15285 -8.96333  0.870 17.84830  ?  287 LYS A D    1 
ATOM   3300 H HA   . LYS A 1 206 ? 34.51505  -20.03530 -10.93221 1.000 17.69282  ?  287 LYS A HA   1 
ATOM   3301 H HB2  . LYS A 1 206 ? 36.55932  -22.14236 -10.19706 1.000 22.31414  ?  287 LYS A HB2  1 
ATOM   3302 H HB3  . LYS A 1 206 ? 36.08693  -21.60972 -11.83475 1.000 22.31414  ?  287 LYS A HB3  1 
ATOM   3303 H HG2  . LYS A 1 206 ? 37.06132  -19.40206 -11.38915 1.000 23.05547  ?  287 LYS A HG2  1 
ATOM   3304 H HG3  . LYS A 1 206 ? 37.55098  -19.95324 -9.76270  1.000 23.05547  ?  287 LYS A HG3  1 
ATOM   3305 H HD2  . LYS A 1 206 ? 38.88581  -21.78480 -10.82935 1.000 32.57413  ?  287 LYS A HD2  1 
ATOM   3306 H HD3  . LYS A 1 206 ? 38.46173  -21.12077 -12.43189 1.000 32.57413  ?  287 LYS A HD3  1 
ATOM   3307 H HE2  . LYS A 1 206 ? 39.74543  -19.21283 -12.12427 1.000 53.15552  ?  287 LYS A HE2  1 
ATOM   3308 H HE3  . LYS A 1 206 ? 39.71672  -19.35666 -10.34455 1.000 53.15552  ?  287 LYS A HE3  1 
ATOM   3309 N N    . SER A 1 207 ? 32.82500  -21.78584 -9.44655  1.000 13.81161  ?  288 SER A N    1 
ATOM   3310 C CA   . SER A 1 207 ? 31.82502  -22.82998 -9.33584  1.000 12.85709  ?  288 SER A CA   1 
ATOM   3311 C C    . SER A 1 207 ? 31.19538  -23.12514 -10.69260 1.000 13.78527  ?  288 SER A C    1 
ATOM   3312 O O    . SER A 1 207 ? 30.82375  -22.19301 -11.41716 1.000 13.40962  ?  288 SER A O    1 
ATOM   3313 C CB   . SER A 1 207 ? 30.70080  -22.38019 -8.39621  1.000 16.10831  ?  288 SER A CB   1 
ATOM   3314 O OG   . SER A 1 207 ? 29.67348  -23.36336 -8.37987  1.000 17.01919  ?  288 SER A OG   1 
ATOM   3315 H H    A SER A 1 207 ? 32.64116  -20.96472 -8.87005  0.040 16.57393  ?  288 SER A H    1 
ATOM   3316 D D    B SER A 1 207 ? 32.63907  -20.96578 -8.86920  0.960 16.57393  ?  288 SER A D    1 
ATOM   3317 H HA   . SER A 1 207 ? 32.30815  -23.73020 -8.95599  1.000 15.42851  ?  288 SER A HA   1 
ATOM   3318 H HB2  . SER A 1 207 ? 31.09951  -22.25824 -7.38910  1.000 19.32998  ?  288 SER A HB2  1 
ATOM   3319 H HB3  . SER A 1 207 ? 30.29009  -21.43512 -8.75154  1.000 19.32998  ?  288 SER A HB3  1 
ATOM   3320 H HG   A SER A 1 207 ? 29.84607  -24.01671 -7.67012  0.170 20.42303  ?  288 SER A HG   1 
ATOM   3321 D DG   B SER A 1 207 ? 29.91118  -24.08628 -7.76238  0.830 20.42303  ?  288 SER A DG   1 
ATOM   3322 N N    . PRO A 1 208 ? 30.98936  -24.39929 -11.03523 1.000 12.73263  ?  289 PRO A N    1 
ATOM   3323 C CA   . PRO A 1 208 ? 30.26801  -24.74320 -12.26283 1.000 14.84706  ?  289 PRO A CA   1 
ATOM   3324 C C    . PRO A 1 208 ? 28.85644  -24.21779 -12.31440 1.000 13.14635  ?  289 PRO A C    1 
ATOM   3325 O O    . PRO A 1 208 ? 28.29026  -24.09562 -13.40004 1.000 15.59657  ?  289 PRO A O    1 
ATOM   3326 C CB   . PRO A 1 208 ? 30.29604  -26.28778 -12.28834 1.000 16.00502  ?  289 PRO A CB   1 
ATOM   3327 C CG   . PRO A 1 208 ? 31.48951  -26.63696 -11.43127 1.000 22.49211  ?  289 PRO A CG   1 
ATOM   3328 C CD   . PRO A 1 208 ? 31.56623  -25.59002 -10.37420 1.000 15.54489  ?  289 PRO A CD   1 
ATOM   3329 H HA   . PRO A 1 208 ? 30.82079  -24.36445 -13.12254 1.000 17.81647  ?  289 PRO A HA   1 
ATOM   3330 H HB2  . PRO A 1 208 ? 29.37473  -26.68867 -11.86574 1.000 19.20603  ?  289 PRO A HB2  1 
ATOM   3331 H HB3  . PRO A 1 208 ? 30.42432  -26.64578 -13.30984 1.000 19.20603  ?  289 PRO A HB3  1 
ATOM   3332 H HG2  . PRO A 1 208 ? 31.34480  -27.62167 -10.98686 1.000 26.99053  ?  289 PRO A HG2  1 
ATOM   3333 H HG3  . PRO A 1 208 ? 32.39211  -26.63272 -12.04234 1.000 26.99053  ?  289 PRO A HG3  1 
ATOM   3334 H HD2  . PRO A 1 208 ? 30.97648  -25.87423 -9.50270  1.000 18.65387  ?  289 PRO A HD2  1 
ATOM   3335 H HD3  . PRO A 1 208 ? 32.60044  -25.40880 -10.08152 1.000 18.65387  ?  289 PRO A HD3  1 
ATOM   3336 N N    . PHE A 1 209 ? 28.27408  -23.85674 -11.17343 1.000 12.33816  ?  290 PHE A N    1 
ATOM   3337 C CA   . PHE A 1 209 ? 26.92293  -23.31430 -11.14902 1.000 11.34883  ?  290 PHE A CA   1 
ATOM   3338 C C    . PHE A 1 209 ? 26.88650  -21.88397 -11.64707 1.000 11.51726  ?  290 PHE A C    1 
ATOM   3339 O O    . PHE A 1 209 ? 25.79146  -21.38543 -11.96529 1.000 13.24587  ?  290 PHE A O    1 
ATOM   3340 C CB   . PHE A 1 209 ? 26.36195  -23.40055 -9.73379  1.000 12.36247  ?  290 PHE A CB   1 
ATOM   3341 C CG   . PHE A 1 209 ? 26.03908  -24.79479 -9.31956  1.000 12.50670  ?  290 PHE A CG   1 
ATOM   3342 C CD1  . PHE A 1 209 ? 25.01391  -25.49120 -9.89319  1.000 15.00243  ?  290 PHE A CD1  1 
ATOM   3343 C CD2  . PHE A 1 209 ? 26.83657  -25.42370 -8.38637  1.000 14.84049  ?  290 PHE A CD2  1 
ATOM   3344 C CE1  . PHE A 1 209 ? 24.73863  -26.81121 -9.49873  1.000 17.60667  ?  290 PHE A CE1  1 
ATOM   3345 C CE2  . PHE A 1 209 ? 26.57718  -26.71426 -7.99998  1.000 16.38509  ?  290 PHE A CE2  1 
ATOM   3346 C CZ   . PHE A 1 209 ? 25.54685  -27.39753 -8.57547  1.000 15.45672  ?  290 PHE A CZ   1 
ATOM   3347 H H    A PHE A 1 209 ? 28.71045  -23.92755 -10.25421 0.250 14.80579  ?  290 PHE A H    1 
ATOM   3348 D D    B PHE A 1 209 ? 28.70890  -23.92684 -10.25343 0.750 14.80579  ?  290 PHE A D    1 
ATOM   3349 H HA   . PHE A 1 209 ? 26.27828  -23.90874 -11.79645 1.000 13.61860  ?  290 PHE A HA   1 
ATOM   3350 H HB2  . PHE A 1 209 ? 27.09989  -23.00477 -9.03601  1.000 14.83496  ?  290 PHE A HB2  1 
ATOM   3351 H HB3  . PHE A 1 209 ? 25.44543  -22.81300 -9.68013  1.000 14.83496  ?  290 PHE A HB3  1 
ATOM   3352 H HD1  . PHE A 1 209 ? 24.40977  -25.02333 -10.65640 1.000 18.00291  ?  290 PHE A HD1  1 
ATOM   3353 H HD2  . PHE A 1 209 ? 27.67378  -24.89478 -7.95541  1.000 17.80859  ?  290 PHE A HD2  1 
ATOM   3354 H HE1  . PHE A 1 209 ? 23.90234  -27.34925 -9.92006  1.000 21.12800  ?  290 PHE A HE1  1 
ATOM   3355 H HE2  . PHE A 1 209 ? 27.18615  -27.18690 -7.24356  1.000 19.66211  ?  290 PHE A HE2  1 
ATOM   3356 H HZ   . PHE A 1 209 ? 25.36921  -28.42453 -8.29244  1.000 18.54807  ?  290 PHE A HZ   1 
ATOM   3357 N N    . ILE A 1 210 ? 28.01186  -21.18811 -11.66912 1.000 11.99762  ?  291 ILE A N    1 
ATOM   3358 C CA   . ILE A 1 210 ? 28.10423  -19.86508 -12.29220 1.000 11.54927  ?  291 ILE A CA   1 
ATOM   3359 C C    . ILE A 1 210 ? 28.24682  -20.11615 -13.78661 1.000 12.38344  ?  291 ILE A C    1 
ATOM   3360 O O    . ILE A 1 210 ? 29.37324  -20.22971 -14.31468 1.000 13.74950  ?  291 ILE A O    1 
ATOM   3361 C CB   . ILE A 1 210 ? 29.25560  -19.04260 -11.70840 1.000 14.01178  ?  291 ILE A CB   1 
ATOM   3362 C CG1  . ILE A 1 210 ? 29.17556  -18.98610 -10.19405 1.000 13.68755  ?  291 ILE A CG1  1 
ATOM   3363 C CG2  . ILE A 1 210 ? 29.24238  -17.63584 -12.29848 1.000 15.88484  ?  291 ILE A CG2  1 
ATOM   3364 C CD1  . ILE A 1 210 ? 30.46889  -18.42965 -9.61889  1.000 18.54210  ?  291 ILE A CD1  1 
ATOM   3365 H H    A ILE A 1 210 ? 28.88979  -21.51021 -11.26183 1.000 14.39714  ?  291 ILE A H    1 
ATOM   3366 D D    B ILE A 1 210 ? 28.88957  -21.51064 -11.26169 0.000 14.39714  ?  291 ILE A D    1 
ATOM   3367 H HA   . ILE A 1 210 ? 27.20723  -19.27311 -12.11036 1.000 13.85913  ?  291 ILE A HA   1 
ATOM   3368 H HB   . ILE A 1 210 ? 30.19242  -19.53240 -11.97403 1.000 16.81413  ?  291 ILE A HB   1 
ATOM   3369 H HG12 . ILE A 1 210 ? 28.35263  -18.33670 -9.89542  1.000 16.42506  ?  291 ILE A HG12 1 
ATOM   3370 H HG13 . ILE A 1 210 ? 29.02077  -19.98990 -9.79843  1.000 16.42506  ?  291 ILE A HG13 1 
ATOM   3371 H HG21 . ILE A 1 210 ? 30.26922  -17.28610 -12.40515 1.000 19.06181  ?  291 ILE A HG21 1 
ATOM   3372 H HG22 . ILE A 1 210 ? 28.75631  -17.66463 -13.27368 1.000 19.06181  ?  291 ILE A HG22 1 
ATOM   3373 H HG23 . ILE A 1 210 ? 28.69237  -16.97510 -11.62839 1.000 19.06181  ?  291 ILE A HG23 1 
ATOM   3374 H HD11 . ILE A 1 210 ? 31.30182  -19.04603 -9.95714  1.000 22.25052  ?  291 ILE A HD11 1 
ATOM   3375 H HD12 . ILE A 1 210 ? 30.59978  -17.40483 -9.96631  1.000 22.25052  ?  291 ILE A HD12 1 
ATOM   3376 H HD13 . ILE A 1 210 ? 30.41040  -18.44860 -8.53063  1.000 22.25052  ?  291 ILE A HD13 1 
ATOM   3377 N N    . LYS A 1 211 ? 27.11600  -20.17872 -14.47950 1.000 11.30969  ?  292 LYS A N    1 
ATOM   3378 C CA   A LYS A 1 211 ? 27.07002  -20.69144 -15.84777 0.460 11.00962  ?  292 LYS A CA   1 
ATOM   3379 C CA   B LYS A 1 211 ? 27.09610  -20.70709 -15.83062 0.540 11.03376  ?  292 LYS A CA   1 
ATOM   3380 C C    . LYS A 1 211 ? 27.57071  -19.66755 -16.83800 1.000 12.68700  ?  292 LYS A C    1 
ATOM   3381 O O    . LYS A 1 211 ? 28.18465  -20.01739 -17.85360 1.000 12.26275  ?  292 LYS A O    1 
ATOM   3382 C CB   A LYS A 1 211 ? 25.63653  -21.04297 -16.23450 0.460 15.35243  ?  292 LYS A CB   1 
ATOM   3383 C CB   B LYS A 1 211 ? 25.68835  -21.22473 -16.13120 0.540 15.80434  ?  292 LYS A CB   1 
ATOM   3384 C CG   A LYS A 1 211 ? 25.09059  -22.34112 -15.73325 0.460 12.27162  ?  292 LYS A CG   1 
ATOM   3385 C CG   B LYS A 1 211 ? 25.57777  -22.12190 -17.34379 0.540 20.65866  ?  292 LYS A CG   1 
ATOM   3386 C CD   A LYS A 1 211 ? 25.86442  -23.56212 -16.19039 0.460 16.77587  ?  292 LYS A CD   1 
ATOM   3387 C CD   B LYS A 1 211 ? 26.16060  -23.50632 -17.12822 0.540 19.79686  ?  292 LYS A CD   1 
ATOM   3388 C CE   A LYS A 1 211 ? 25.50192  -24.08789 -17.58730 0.460 16.64996  ?  292 LYS A CE   1 
ATOM   3389 C CE   B LYS A 1 211 ? 26.33566  -24.26726 -18.46600 0.540 17.92601  ?  292 LYS A CE   1 
ATOM   3390 N NZ   A LYS A 1 211 ? 26.47436  -25.19471 -17.91325 0.460 18.77000  ?  292 LYS A NZ   1 
ATOM   3391 N NZ   B LYS A 1 211 ? 27.40894  -23.64446 -19.31778 0.540 24.01818  ?  292 LYS A NZ   1 
ATOM   3392 H H    A LYS A 1 211 ? 26.20722  -19.88170 -14.12409 0.460 13.57162  ?  292 LYS A H    1 
ATOM   3393 H H    B LYS A 1 211 ? 26.20593  -19.87359 -14.13443 0.540 13.57162  ?  292 LYS A H    1 
ATOM   3394 H HA   A LYS A 1 211 ? 27.69542  -21.58344 -15.88392 0.460 13.21155  ?  292 LYS A HA   1 
ATOM   3395 H HA   B LYS A 1 211 ? 27.77842  -21.55169 -15.92644 0.540 13.24051  ?  292 LYS A HA   1 
ATOM   3396 H HB2  A LYS A 1 211 ? 24.98435  -20.25760 -15.85246 0.460 18.42292  ?  292 LYS A HB2  1 
ATOM   3397 H HB2  B LYS A 1 211 ? 25.34064  -21.79589 -15.27040 0.540 18.96521  ?  292 LYS A HB2  1 
ATOM   3398 H HB3  A LYS A 1 211 ? 25.58180  -21.07652 -17.32261 0.460 18.42292  ?  292 LYS A HB3  1 
ATOM   3399 H HB3  B LYS A 1 211 ? 25.03527  -20.36829 -16.29881 0.540 18.96521  ?  292 LYS A HB3  1 
ATOM   3400 H HG2  A LYS A 1 211 ? 25.10813  -22.32943 -14.64345 0.460 14.72595  ?  292 LYS A HG2  1 
ATOM   3401 H HG2  B LYS A 1 211 ? 24.52486  -22.24014 -17.59974 0.540 24.79039  ?  292 LYS A HG2  1 
ATOM   3402 H HG3  A LYS A 1 211 ? 24.06576  -22.44903 -16.08847 0.460 14.72595  ?  292 LYS A HG3  1 
ATOM   3403 H HG3  B LYS A 1 211 ? 26.11357  -21.66063 -18.17339 0.540 24.79039  ?  292 LYS A HG3  1 
ATOM   3404 H HD2  A LYS A 1 211 ? 26.92524  -23.31196 -16.20392 0.460 20.13105  ?  292 LYS A HD2  1 
ATOM   3405 H HD2  B LYS A 1 211 ? 27.13871  -23.41604 -16.65574 0.540 23.75624  ?  292 LYS A HD2  1 
ATOM   3406 H HD3  A LYS A 1 211 ? 25.68103  -24.37054 -15.48263 0.460 20.13105  ?  292 LYS A HD3  1 
ATOM   3407 H HD3  B LYS A 1 211 ? 25.49084  -24.08418 -16.49134 0.540 23.75624  ?  292 LYS A HD3  1 
ATOM   3408 H HE2  A LYS A 1 211 ? 24.48647  -24.48405 -17.59158 0.460 19.97996  ?  292 LYS A HE2  1 
ATOM   3409 H HE2  B LYS A 1 211 ? 26.61763  -25.29976 -18.25975 0.540 21.51121  ?  292 LYS A HE2  1 
ATOM   3410 H HE3  A LYS A 1 211 ? 25.59519  -23.29321 -18.32750 0.460 19.97996  ?  292 LYS A HE3  1 
ATOM   3411 H HE3  B LYS A 1 211 ? 25.39835  -24.24068 -19.02172 0.540 21.51121  ?  292 LYS A HE3  1 
ATOM   3412 N N    . GLY A 1 212 ? 27.27524  -18.38554 -16.59621 1.000 11.37798  ?  293 GLY A N    1 
ATOM   3413 C CA   . GLY A 1 212 ? 27.63758  -17.37712 -17.56304 1.000 10.83624  ?  293 GLY A CA   1 
ATOM   3414 C C    . GLY A 1 212 ? 26.87887  -16.09333 -17.32750 1.000 10.54949  ?  293 GLY A C    1 
ATOM   3415 O O    . GLY A 1 212 ? 26.79805  -15.62987 -16.19051 1.000 10.51037  ?  293 GLY A O    1 
ATOM   3416 H H    A GLY A 1 212 ? 26.80047  -18.03889 -15.76265 1.000 13.65357  ?  293 GLY A H    1 
ATOM   3417 D D    B GLY A 1 212 ? 26.80050  -18.03840 -15.76284 0.000 13.65357  ?  293 GLY A D    1 
ATOM   3418 H HA2  . GLY A 1 212 ? 28.70523  -17.16950 -17.49158 1.000 13.00349  ?  293 GLY A HA2  1 
ATOM   3419 H HA3  . GLY A 1 212 ? 27.41233  -17.73623 -18.56724 1.000 13.00349  ?  293 GLY A HA3  1 
ATOM   3420 N N    . LEU A 1 213 ? 26.42288  -15.48572 -18.42016 1.000 10.27805  ?  294 LEU A N    1 
ATOM   3421 C CA   . LEU A 1 213 ? 25.93756  -14.10877 -18.41098 1.000 10.39142  ?  294 LEU A CA   1 
ATOM   3422 C C    . LEU A 1 213 ? 24.56651  -14.04763 -19.06366 1.000 9.85667   ?  294 LEU A C    1 
ATOM   3423 O O    . LEU A 1 213 ? 24.22344  -14.86694 -19.92718 1.000 10.95766  ?  294 LEU A O    1 
ATOM   3424 C CB   . LEU A 1 213 ? 26.90244  -13.18006 -19.19144 1.000 11.06200  ?  294 LEU A CB   1 
ATOM   3425 C CG   . LEU A 1 213 ? 28.32877  -13.22135 -18.64329 1.000 12.56692  ?  294 LEU A CG   1 
ATOM   3426 C CD1  . LEU A 1 213 ? 29.22230  -12.37012 -19.53188 1.000 14.78952  ?  294 LEU A CD1  1 
ATOM   3427 C CD2  . LEU A 1 213 ? 28.41538  -12.74814 -17.21535 1.000 14.57992  ?  294 LEU A CD2  1 
ATOM   3428 H H    A LEU A 1 213 ? 26.37680  -15.92760 -19.33832 1.000 12.33366  ?  294 LEU A H    1 
ATOM   3429 D D    B LEU A 1 213 ? 26.37745  -15.92904 -19.33766 0.000 12.33366  ?  294 LEU A D    1 
ATOM   3430 H HA   . LEU A 1 213 ? 25.85131  -13.75827 -17.38248 1.000 12.46971  ?  294 LEU A HA   1 
ATOM   3431 H HB2  . LEU A 1 213 ? 26.93093  -13.49435 -20.23476 1.000 13.27440  ?  294 LEU A HB2  1 
ATOM   3432 H HB3  . LEU A 1 213 ? 26.54168  -12.15391 -19.12092 1.000 13.27440  ?  294 LEU A HB3  1 
ATOM   3433 H HG   . LEU A 1 213 ? 28.67054  -14.25638 -18.64454 1.000 15.08031  ?  294 LEU A HG   1 
ATOM   3434 H HD11 . LEU A 1 213 ? 30.18524  -12.23329 -19.03982 1.000 17.74742  ?  294 LEU A HD11 1 
ATOM   3435 H HD12 . LEU A 1 213 ? 29.36137  -12.87825 -20.48612 1.000 17.74742  ?  294 LEU A HD12 1 
ATOM   3436 H HD13 . LEU A 1 213 ? 28.74582  -11.40291 -19.69178 1.000 17.74742  ?  294 LEU A HD13 1 
ATOM   3437 H HD21 . LEU A 1 213 ? 27.90365  -11.78975 -17.12745 1.000 17.49590  ?  294 LEU A HD21 1 
ATOM   3438 H HD22 . LEU A 1 213 ? 27.93921  -13.48451 -16.56797 1.000 17.49590  ?  294 LEU A HD22 1 
ATOM   3439 H HD23 . LEU A 1 213 ? 29.46449  -12.63580 -16.94175 1.000 17.49590  ?  294 LEU A HD23 1 
ATOM   3440 N N    . ALA A 1 214 ? 23.78116  -13.05039 -18.65016 1.000 9.66376   ?  295 ALA A N    1 
ATOM   3441 C CA   . ALA A 1 214 ? 22.49344  -12.72598 -19.25340 1.000 9.30628   ?  295 ALA A CA   1 
ATOM   3442 C C    . ALA A 1 214 ? 22.59143  -11.37952 -19.94342 1.000 9.21301   ?  295 ALA A C    1 
ATOM   3443 O O    . ALA A 1 214 ? 23.17860  -10.44498 -19.39732 1.000 11.73456  ?  295 ALA A O    1 
ATOM   3444 C CB   . ALA A 1 214 ? 21.40420  -12.65564 -18.20094 1.000 10.42756  ?  295 ALA A CB   1 
ATOM   3445 H H    A ALA A 1 214 ? 24.02139  -12.43278 -17.87475 1.000 11.59652  ?  295 ALA A H    1 
ATOM   3446 D D    B ALA A 1 214 ? 24.02339  -12.43394 -17.87445 0.000 11.59652  ?  295 ALA A D    1 
ATOM   3447 H HA   . ALA A 1 214 ? 22.22897  -13.49104 -19.98336 1.000 11.16754  ?  295 ALA A HA   1 
ATOM   3448 H HB1  . ALA A 1 214 ? 20.43299  -12.64387 -18.69563 1.000 12.51308  ?  295 ALA A HB1  1 
ATOM   3449 H HB2  . ALA A 1 214 ? 21.48047  -13.52839 -17.55242 1.000 12.51308  ?  295 ALA A HB2  1 
ATOM   3450 H HB3  . ALA A 1 214 ? 21.53437  -11.74526 -17.61582 1.000 12.51308  ?  295 ALA A HB3  1 
ATOM   3451 N N    . THR A 1 215 ? 22.01979  -11.26047 -21.14623 1.000 9.81009   ?  296 THR A N    1 
ATOM   3452 C CA   . THR A 1 215 ? 22.06847  -10.00670 -21.86839 1.000 9.66153   ?  296 THR A CA   1 
ATOM   3453 C C    . THR A 1 215 ? 20.68303  -9.54113  -22.27104 1.000 10.23179  ?  296 THR A C    1 
ATOM   3454 O O    . THR A 1 215 ? 19.72321  -10.31396 -22.32491 1.000 10.37082  ?  296 THR A O    1 
ATOM   3455 C CB   . THR A 1 215 ? 23.00159  -10.03348 -23.08379 1.000 10.44857  ?  296 THR A CB   1 
ATOM   3456 O OG1  . THR A 1 215 ? 22.34934  -10.64625 -24.18778 1.000 12.45050  ?  296 THR A OG1  1 
ATOM   3457 C CG2  . THR A 1 215 ? 24.27840  -10.73867 -22.81096 1.000 13.95759  ?  296 THR A CG2  1 
ATOM   3458 H H    A THR A 1 215 ? 21.52570  -12.01081 -21.62920 0.970 11.77211  ?  296 THR A H    1 
ATOM   3459 D D    B THR A 1 215 ? 21.52599  -12.01180 -21.62797 0.030 11.77211  ?  296 THR A D    1 
ATOM   3460 H HA   . THR A 1 215 ? 22.46605  -9.26331  -21.17745 1.000 11.59383  ?  296 THR A HA   1 
ATOM   3461 H HB   . THR A 1 215 ? 23.25422  -9.00203  -23.32950 1.000 12.53828  ?  296 THR A HB   1 
ATOM   3462 H HG1  A THR A 1 215 ? 22.25918  -10.00399 -24.92247 0.000 14.94060  ?  296 THR A HG1  1 
ATOM   3463 D DG1  B THR A 1 215 ? 22.42034  -10.07294 -24.97941 1.000 14.94060  ?  296 THR A DG1  1 
ATOM   3464 H HG21 . THR A 1 215 ? 24.07767  -11.75176 -22.46245 1.000 16.74911  ?  296 THR A HG21 1 
ATOM   3465 H HG22 . THR A 1 215 ? 24.87781  -10.78953 -23.71993 1.000 16.74911  ?  296 THR A HG22 1 
ATOM   3466 H HG23 . THR A 1 215 ? 24.84205  -10.20621 -22.04488 1.000 16.74911  ?  296 THR A HG23 1 
ATOM   3467 N N    . ASN A 1 216 ? 20.59938  -8.24326  -22.54412 1.000 9.37398   ?  297 ASN A N    1 
ATOM   3468 C CA   . ASN A 1 216 ? 19.37764  -7.58681  -23.02057 1.000 9.23974   ?  297 ASN A CA   1 
ATOM   3469 C C    . ASN A 1 216 ? 18.24598  -7.57162  -22.01673 1.000 9.76529   ?  297 ASN A C    1 
ATOM   3470 O O    . ASN A 1 216 ? 17.10193  -7.33847  -22.39632 1.000 10.65153  ?  297 ASN A O    1 
ATOM   3471 C CB   . ASN A 1 216 ? 18.88645  -8.19878  -24.33997 1.000 10.92365  ?  297 ASN A CB   1 
ATOM   3472 C CG   . ASN A 1 216 ? 18.10198  -7.21764  -25.20534 1.000 11.41464  ?  297 ASN A CG   1 
ATOM   3473 O OD1  . ASN A 1 216 ? 18.49240  -6.06516  -25.42445 1.000 12.45177  ?  297 ASN A OD1  1 
ATOM   3474 N ND2  . ASN A 1 216 ? 16.97442  -7.70215  -25.72116 1.000 13.13331  ?  297 ASN A ND2  1 
ATOM   3475 H H    A ASN A 1 216 ? 21.38266  -7.59773  -22.44333 1.000 11.24878  ?  297 ASN A H    1 
ATOM   3476 D D    B ASN A 1 216 ? 21.38414  -7.59965  -22.44254 0.000 11.24878  ?  297 ASN A D    1 
ATOM   3477 H HA   . ASN A 1 216 ? 19.64427  -6.54428  -23.19417 1.000 11.08769  ?  297 ASN A HA   1 
ATOM   3478 H HB2  . ASN A 1 216 ? 19.74877  -8.53632  -24.91492 1.000 13.10838  ?  297 ASN A HB2  1 
ATOM   3479 H HB3  . ASN A 1 216 ? 18.23409  -9.04283  -24.11611 1.000 13.10838  ?  297 ASN A HB3  1 
ATOM   3480 H HD21 A ASN A 1 216 ? 16.69579  -8.66359  -25.52522 0.980 15.75998  ?  297 ASN A HD21 1 
ATOM   3481 D DD21 B ASN A 1 216 ? 16.69579  -8.66359  -25.52522 0.020 15.75998  ?  297 ASN A DD21 1 
ATOM   3482 H HD22 A ASN A 1 216 ? 16.38912  -7.11194  -26.31232 0.940 15.75998  ?  297 ASN A HD22 1 
ATOM   3483 D DD22 B ASN A 1 216 ? 16.38912  -7.11194  -26.31232 0.060 15.75998  ?  297 ASN A DD22 1 
ATOM   3484 N N    . VAL A 1 217 ? 18.53704  -7.79690  -20.73467 1.000 9.78872   ?  298 VAL A N    1 
ATOM   3485 C CA   . VAL A 1 217 ? 17.48665  -7.85348  -19.70846 1.000 9.92920   ?  298 VAL A CA   1 
ATOM   3486 C C    . VAL A 1 217 ? 16.74265  -6.53598  -19.66266 1.000 9.78760   ?  298 VAL A C    1 
ATOM   3487 O O    . VAL A 1 217 ? 17.34106  -5.45835  -19.50563 1.000 11.38125  ?  298 VAL A O    1 
ATOM   3488 C CB   . VAL A 1 217 ? 18.08165  -8.20482  -18.33714 1.000 9.14562   ?  298 VAL A CB   1 
ATOM   3489 C CG1  . VAL A 1 217 ? 17.01934  -8.11209  -17.28164 1.000 11.05368  ?  298 VAL A CG1  1 
ATOM   3490 C CG2  . VAL A 1 217 ? 18.68505  -9.59787  -18.38922 1.000 11.84124  ?  298 VAL A CG2  1 
ATOM   3491 H H    A VAL A 1 217 ? 19.47959  -7.94337  -20.37336 0.840 11.74647  ?  298 VAL A H    1 
ATOM   3492 D D    B VAL A 1 217 ? 19.47893  -7.94356  -20.37173 0.160 11.74647  ?  298 VAL A D    1 
ATOM   3493 H HA   . VAL A 1 217 ? 16.77752  -8.63200  -19.98976 1.000 11.91504  ?  298 VAL A HA   1 
ATOM   3494 H HB   . VAL A 1 217 ? 18.87190  -7.50027  -18.07789 1.000 10.97474  ?  298 VAL A HB   1 
ATOM   3495 H HG11 . VAL A 1 217 ? 16.63405  -7.09282  -17.25452 1.000 13.26441  ?  298 VAL A HG11 1 
ATOM   3496 H HG12 . VAL A 1 217 ? 16.21558  -8.80693  -17.52510 1.000 13.26441  ?  298 VAL A HG12 1 
ATOM   3497 H HG13 . VAL A 1 217 ? 17.45462  -8.37073  -16.31638 1.000 13.26441  ?  298 VAL A HG13 1 
ATOM   3498 H HG21 . VAL A 1 217 ? 18.65648  -10.03452 -17.39091 1.000 14.20949  ?  298 VAL A HG21 1 
ATOM   3499 H HG22 . VAL A 1 217 ? 18.10495  -10.21029 -19.07952 1.000 14.20949  ?  298 VAL A HG22 1 
ATOM   3500 H HG23 . VAL A 1 217 ? 19.71661  -9.52512  -18.73372 1.000 14.20949  ?  298 VAL A HG23 1 
ATOM   3501 N N    . ALA A 1 218 ? 15.43538  -6.60831  -19.82940 1.000 10.55197  ?  299 ALA A N    1 
ATOM   3502 C CA   . ALA A 1 218 ? 14.57361  -5.42012  -19.79543 1.000 11.23948  ?  299 ALA A CA   1 
ATOM   3503 C C    . ALA A 1 218 ? 14.86067  -4.44737  -20.94244 1.000 12.09422  ?  299 ALA A C    1 
ATOM   3504 O O    . ALA A 1 218 ? 14.36699  -3.31069  -20.94615 1.000 14.37391  ?  299 ALA A O    1 
ATOM   3505 C CB   . ALA A 1 218 ? 14.60801  -4.68791  -18.44514 1.000 13.81391  ?  299 ALA A CB   1 
ATOM   3506 H H    A ALA A 1 218 ? 14.92951  -7.47897  -19.99202 0.110 12.66237  ?  299 ALA A H    1 
ATOM   3507 D D    B ALA A 1 218 ? 14.93164  -7.48022  -19.99191 0.890 12.66237  ?  299 ALA A D    1 
ATOM   3508 H HA   . ALA A 1 218 ? 13.55188  -5.77761  -19.92340 1.000 13.48738  ?  299 ALA A HA   1 
ATOM   3509 H HB1  . ALA A 1 218 ? 13.85606  -3.89883  -18.45009 1.000 16.57669  ?  299 ALA A HB1  1 
ATOM   3510 H HB2  . ALA A 1 218 ? 14.39328  -5.40099  -17.64921 1.000 16.57669  ?  299 ALA A HB2  1 
ATOM   3511 H HB3  . ALA A 1 218 ? 15.59852  -4.25655  -18.30050 1.000 16.57669  ?  299 ALA A HB3  1 
ATOM   3512 N N    . ASN A 1 219 ? 15.57663  -4.87045  -21.96981 1.000 11.24589  ?  300 ASN A N    1 
ATOM   3513 C CA   . ASN A 1 219 ? 15.82870  -4.03123  -23.12570 1.000 10.35086  ?  300 ASN A CA   1 
ATOM   3514 C C    . ASN A 1 219 ? 15.10078  -4.56041  -24.35383 1.000 10.50482  ?  300 ASN A C    1 
ATOM   3515 O O    . ASN A 1 219 ? 14.16918  -5.36777  -24.24355 1.000 12.56999  ?  300 ASN A O    1 
ATOM   3516 C CB   . ASN A 1 219 ? 17.35068  -3.84457  -23.27711 1.000 12.12460  ?  300 ASN A CB   1 
ATOM   3517 C CG   . ASN A 1 219 ? 17.72308  -2.48375  -23.86565 1.000 14.34845  ?  300 ASN A CG   1 
ATOM   3518 O OD1  . ASN A 1 219 ? 17.62345  -2.29731  -25.08552 1.000 15.83175  ?  300 ASN A OD1  1 
ATOM   3519 N ND2  . ASN A 1 219 ? 18.15079  -1.53571  -23.02542 1.000 16.85583  ?  300 ASN A ND2  1 
ATOM   3520 H H    A ASN A 1 219 ? 15.99801  -5.79741  -22.02958 1.000 13.49507  ?  300 ASN A H    1 
ATOM   3521 D D    B ASN A 1 219 ? 15.99702  -5.79801  -22.02721 0.000 13.49507  ?  300 ASN A D    1 
ATOM   3522 H HA   . ASN A 1 219 ? 15.40511  -3.04255  -22.94909 1.000 12.42104  ?  300 ASN A HA   1 
ATOM   3523 H HB2  . ASN A 1 219 ? 17.81815  -3.92692  -22.29589 1.000 14.54952  ?  300 ASN A HB2  1 
ATOM   3524 H HB3  . ASN A 1 219 ? 17.73909  -4.61682  -23.94109 1.000 14.54952  ?  300 ASN A HB3  1 
ATOM   3525 H HD22 A ASN A 1 219 ? 18.22984  -1.73578  -22.02836 0.000 20.22699  ?  300 ASN A HD22 1 
ATOM   3526 D DD22 B ASN A 1 219 ? 18.21778  -1.73182  -22.02669 1.000 20.22699  ?  300 ASN A DD22 1 
ATOM   3527 N N    . TYR A 1 220 ? 15.52162  -4.08037  -25.53126 1.000 11.73977  ?  301 TYR A N    1 
ATOM   3528 C CA   . TYR A 1 220 ? 14.71782  -4.17793  -26.73776 1.000 12.86141  ?  301 TYR A CA   1 
ATOM   3529 C C    . TYR A 1 220 ? 15.54459  -4.56446  -27.95469 1.000 12.28365  ?  301 TYR A C    1 
ATOM   3530 O O    . TYR A 1 220 ? 15.00922  -4.53694  -29.06811 1.000 13.67665  ?  301 TYR A O    1 
ATOM   3531 C CB   . TYR A 1 220 ? 14.04993  -2.82406  -27.02334 1.000 12.60056  ?  301 TYR A CB   1 
ATOM   3532 C CG   . TYR A 1 220 ? 13.29061  -2.20106  -25.87610 1.000 12.19432  ?  301 TYR A CG   1 
ATOM   3533 C CD1  . TYR A 1 220 ? 13.94748  -1.41627  -24.95738 1.000 14.68818  ?  301 TYR A CD1  1 
ATOM   3534 C CD2  . TYR A 1 220 ? 11.91268  -2.38760  -25.72793 1.000 12.61038  ?  301 TYR A CD2  1 
ATOM   3535 C CE1  . TYR A 1 220 ? 13.26615  -0.81236  -23.89915 1.000 13.50180  ?  301 TYR A CE1  1 
ATOM   3536 C CE2  . TYR A 1 220 ? 11.21735  -1.79494  -24.68431 1.000 12.83409  ?  301 TYR A CE2  1 
ATOM   3537 C CZ   . TYR A 1 220 ? 11.90481  -0.99677  -23.79978 1.000 14.73195  ?  301 TYR A CZ   1 
ATOM   3538 O OH   . TYR A 1 220 ? 11.19185  -0.37974  -22.77900 1.000 16.41785  ?  301 TYR A OH   1 
ATOM   3539 H H    A TYR A 1 220 ? 16.41970  -3.61808  -25.67317 0.210 14.08772  ?  301 TYR A H    1 
ATOM   3540 D D    B TYR A 1 220 ? 16.41959  -3.61802  -25.67364 0.790 14.08772  ?  301 TYR A D    1 
ATOM   3541 H HA   . TYR A 1 220 ? 13.93800  -4.92532  -26.59149 1.000 15.43369  ?  301 TYR A HA   1 
ATOM   3542 H HB2  . TYR A 1 220 ? 14.82620  -2.11712  -27.31617 1.000 15.12068  ?  301 TYR A HB2  1 
ATOM   3543 H HB3  . TYR A 1 220 ? 13.34190  -2.96002  -27.84084 1.000 15.12068  ?  301 TYR A HB3  1 
ATOM   3544 H HD1  . TYR A 1 220 ? 15.01209  -1.26410  -25.05663 1.000 17.62582  ?  301 TYR A HD1  1 
ATOM   3545 H HD2  . TYR A 1 220 ? 11.38091  -3.00351  -26.43806 1.000 15.13246  ?  301 TYR A HD2  1 
ATOM   3546 H HE1  . TYR A 1 220 ? 13.79555  -0.21292  -23.17334 1.000 16.20217  ?  301 TYR A HE1  1 
ATOM   3547 H HE2  . TYR A 1 220 ? 10.15592  -1.95715  -24.56836 1.000 15.40091  ?  301 TYR A HE2  1 
ATOM   3548 H HH   A TYR A 1 220 ? 11.81014  0.03075   -22.13900 0.000 19.70143  ?  301 TYR A HH   1 
ATOM   3549 D DH   B TYR A 1 220 ? 11.79393  0.16814   -22.23337 1.000 19.70143  ?  301 TYR A DH   1 
ATOM   3550 N N    . ASN A 1 221 ? 16.83045  -4.89763  -27.78916 1.000 11.97815  ?  302 ASN A N    1 
ATOM   3551 C CA   . ASN A 1 221 ? 17.70106  -5.17796  -28.91333 1.000 11.83440  ?  302 ASN A CA   1 
ATOM   3552 C C    . ASN A 1 221 ? 17.28149  -6.48299  -29.57191 1.000 13.02984  ?  302 ASN A C    1 
ATOM   3553 O O    . ASN A 1 221 ? 16.72923  -7.39578  -28.95103 1.000 13.02285  ?  302 ASN A O    1 
ATOM   3554 C CB   . ASN A 1 221 ? 19.15107  -5.32911  -28.48752 1.000 11.69836  ?  302 ASN A CB   1 
ATOM   3555 C CG   . ASN A 1 221 ? 19.77917  -4.08584  -27.96767 1.000 13.08905  ?  302 ASN A CG   1 
ATOM   3556 O OD1  . ASN A 1 221 ? 19.24123  -2.96796  -28.12582 1.000 14.38791  ?  302 ASN A OD1  1 
ATOM   3557 N ND2  . ASN A 1 221 ? 20.94293  -4.23034  -27.35430 1.000 13.51980  ?  302 ASN A ND2  1 
ATOM   3558 H H    A ASN A 1 221 ? 17.29062  -4.97933  -26.88253 0.630 14.37378  ?  302 ASN A H    1 
ATOM   3559 D D    B ASN A 1 221 ? 17.29187  -4.97969  -26.88320 0.370 14.37378  ?  302 ASN A D    1 
ATOM   3560 H HA   . ASN A 1 221 ? 17.63237  -4.34409  -29.61193 1.000 14.20128  ?  302 ASN A HA   1 
ATOM   3561 H HB2  . ASN A 1 221 ? 19.20410  -6.07808  -27.69738 1.000 14.03803  ?  302 ASN A HB2  1 
ATOM   3562 H HB3  . ASN A 1 221 ? 19.73339  -5.65467  -29.34949 1.000 14.03803  ?  302 ASN A HB3  1 
ATOM   3563 N N    . ALA A 1 222 ? 17.54966  -6.57414  -30.87101 1.000 13.02438  ?  303 ALA A N    1 
ATOM   3564 C CA   . ALA A 1 222 ? 17.36609  -7.84613  -31.55636 1.000 13.58988  ?  303 ALA A CA   1 
ATOM   3565 C C    . ALA A 1 222 ? 18.44973  -8.84301  -31.14192 1.000 12.45503  ?  303 ALA A C    1 
ATOM   3566 O O    . ALA A 1 222 ? 19.58523  -8.46582  -30.83992 1.000 12.94164  ?  303 ALA A O    1 
ATOM   3567 C CB   . ALA A 1 222 ? 17.42568  -7.62886  -33.08064 1.000 16.34382  ?  303 ALA A CB   1 
ATOM   3568 H H    A ALA A 1 222 ? 17.88464  -5.80970  -31.45736 0.140 15.62926  ?  303 ALA A H    1 
ATOM   3569 D D    B ALA A 1 222 ? 17.88466  -5.81055  -31.45846 0.860 15.62926  ?  303 ALA A D    1 
ATOM   3570 H HA   . ALA A 1 222 ? 16.39470  -8.26650  -31.29600 1.000 16.30786  ?  303 ALA A HA   1 
ATOM   3571 H HB1  . ALA A 1 222 ? 16.46694  -7.23768  -33.42108 1.000 19.61259  ?  303 ALA A HB1  1 
ATOM   3572 H HB2  . ALA A 1 222 ? 18.21919  -6.91663  -33.30682 1.000 19.61259  ?  303 ALA A HB2  1 
ATOM   3573 H HB3  . ALA A 1 222 ? 17.63207  -8.58216  -33.56718 1.000 19.61259  ?  303 ALA A HB3  1 
ATOM   3574 N N    . LEU A 1 223 ? 18.10095  -10.13073 -31.15330 1.000 12.89456  ?  304 LEU A N    1 
ATOM   3575 C CA   . LEU A 1 223 ? 19.13819  -11.16522 -31.10660 1.000 13.29251  ?  304 LEU A CA   1 
ATOM   3576 C C    . LEU A 1 223 ? 19.94796  -11.16224 -32.40469 1.000 14.30251  ?  304 LEU A C    1 
ATOM   3577 O O    . LEU A 1 223 ? 21.17627  -11.03902 -32.39702 1.000 15.10006  ?  304 LEU A O    1 
ATOM   3578 C CB   . LEU A 1 223 ? 18.49150  -12.53084 -30.83988 1.000 16.62290  ?  304 LEU A CB   1 
ATOM   3579 C CG   . LEU A 1 223 ? 19.48469  -13.69690 -30.82856 1.000 16.17552  ?  304 LEU A CG   1 
ATOM   3580 C CD1  . LEU A 1 223 ? 20.56113  -13.54469 -29.79484 1.000 18.04947  ?  304 LEU A CD1  1 
ATOM   3581 C CD2  . LEU A 1 223 ? 18.73129  -15.01688 -30.61615 1.000 24.83812  ?  304 LEU A CD2  1 
ATOM   3582 H H    A LEU A 1 223 ? 17.14358  -10.48041 -31.19294 0.060 15.47348  ?  304 LEU A H    1 
ATOM   3583 D D    B LEU A 1 223 ? 17.14438  -10.48260 -31.19290 0.940 15.47348  ?  304 LEU A D    1 
ATOM   3584 H HA   . LEU A 1 223 ? 19.82749  -10.96802 -30.28557 1.000 15.95101  ?  304 LEU A HA   1 
ATOM   3585 H HB2  . LEU A 1 223 ? 18.00228  -12.50105 -29.86629 1.000 19.94748  ?  304 LEU A HB2  1 
ATOM   3586 H HB3  . LEU A 1 223 ? 17.75660  -12.72733 -31.62053 1.000 19.94748  ?  304 LEU A HB3  1 
ATOM   3587 H HG   . LEU A 1 223 ? 19.98938  -13.70909 -31.79461 1.000 19.41062  ?  304 LEU A HG   1 
ATOM   3588 H HD11 . LEU A 1 223 ? 21.27890  -14.35722 -29.90763 1.000 21.65936  ?  304 LEU A HD11 1 
ATOM   3589 H HD12 . LEU A 1 223 ? 21.05917  -12.58600 -29.93963 1.000 21.65936  ?  304 LEU A HD12 1 
ATOM   3590 H HD13 . LEU A 1 223 ? 20.10924  -13.58285 -28.80366 1.000 21.65936  ?  304 LEU A HD13 1 
ATOM   3591 H HD21 . LEU A 1 223 ? 19.32614  -15.83450 -31.02328 1.000 29.80575  ?  304 LEU A HD21 1 
ATOM   3592 H HD22 . LEU A 1 223 ? 18.57381  -15.16772 -29.54818 1.000 29.80575  ?  304 LEU A HD22 1 
ATOM   3593 H HD23 . LEU A 1 223 ? 17.77126  -14.96413 -31.12963 1.000 29.80575  ?  304 LEU A HD23 1 
ATOM   3594 N N    . GLN A 1 224 ? 19.24972  -11.25425 -33.53319 1.000 15.73985  ?  305 GLN A N    1 
ATOM   3595 C CA   . GLN A 1 224 ? 19.87131  -11.28863 -34.86703 1.000 18.97878  ?  305 GLN A CA   1 
ATOM   3596 C C    . GLN A 1 224 ? 19.07310  -10.33639 -35.75477 1.000 19.95288  ?  305 GLN A C    1 
ATOM   3597 O O    . GLN A 1 224 ? 17.91306  -10.58257 -36.08400 1.000 22.95513  ?  305 GLN A O    1 
ATOM   3598 C CB   . GLN A 1 224 ? 19.91676  -12.72267 -35.40046 1.000 23.11315  ?  305 GLN A CB   1 
ATOM   3599 C CG   . GLN A 1 224 ? 20.64745  -12.86861 -36.74046 1.000 58.68548  ?  305 GLN A CG   1 
ATOM   3600 C CD   . GLN A 1 224 ? 21.43144  -14.17078 -36.85614 1.000 53.21007  ?  305 GLN A CD   1 
ATOM   3601 O OE1  . GLN A 1 224 ? 22.56431  -14.18224 -37.34460 1.000 63.35545  ?  305 GLN A OE1  1 
ATOM   3602 N NE2  . GLN A 1 224 ? 20.83557  -15.26779 -36.39959 1.000 53.62237  ?  305 GLN A NE2  1 
ATOM   3603 H H    A GLN A 1 224 ? 18.23159  -11.30808 -33.56327 0.080 18.88782  ?  305 GLN A H    1 
ATOM   3604 D D    B GLN A 1 224 ? 18.23152  -11.30796 -33.56094 0.920 18.88782  ?  305 GLN A D    1 
ATOM   3605 H HA   . GLN A 1 224 ? 20.89798  -10.92397 -34.83405 1.000 22.77454  ?  305 GLN A HA   1 
ATOM   3606 H HB2  . GLN A 1 224 ? 20.43151  -13.34968 -34.67245 1.000 27.73578  ?  305 GLN A HB2  1 
ATOM   3607 H HB3  . GLN A 1 224 ? 18.89499  -13.07561 -35.54015 1.000 27.73578  ?  305 GLN A HB3  1 
ATOM   3608 H HG2  . GLN A 1 224 ? 19.91474  -12.84560 -37.54712 1.000 70.42258  ?  305 GLN A HG2  1 
ATOM   3609 H HG3  . GLN A 1 224 ? 21.35040  -12.04302 -36.85167 1.000 70.42258  ?  305 GLN A HG3  1 
ATOM   3610 N N    . ALA A 1 225 ? 19.64637  -9.19708  -36.02569 1.000 17.62901  ?  306 ALA A N    1 
ATOM   3611 C CA   . ALA A 1 225 ? 18.98314  -8.14773  -36.80593 1.000 20.71095  ?  306 ALA A CA   1 
ATOM   3612 C C    . ALA A 1 225 ? 19.19048  -8.37366  -38.30204 1.000 26.30676  ?  306 ALA A C    1 
ATOM   3613 O O    . ALA A 1 225 ? 20.30168  -8.66248  -38.74442 1.000 25.69865  ?  306 ALA A O    1 
ATOM   3614 C CB   . ALA A 1 225 ? 19.55962  -6.77620  -36.46871 1.000 18.19930  ?  306 ALA A CB   1 
ATOM   3615 H H    A ALA A 1 225 ? 20.58739  -8.94649  -35.72221 0.000 21.15482  ?  306 ALA A H    1 
ATOM   3616 D D    B ALA A 1 225 ? 20.58745  -8.94715  -35.72188 1.000 21.15482  ?  306 ALA A D    1 
ATOM   3617 H HA   . ALA A 1 225 ? 17.91888  -8.17368  -36.57187 1.000 24.85314  ?  306 ALA A HA   1 
ATOM   3618 H HB1  . ALA A 1 225 ? 19.63157  -6.67806  -35.38552 1.000 21.83916  ?  306 ALA A HB1  1 
ATOM   3619 H HB2  . ALA A 1 225 ? 20.54940  -6.68741  -36.91654 1.000 21.83916  ?  306 ALA A HB2  1 
ATOM   3620 H HB3  . ALA A 1 225 ? 18.90020  -6.00598  -36.86873 1.000 21.83916  ?  306 ALA A HB3  1 
ATOM   3621 N N    . ALA A 1 226 ? 18.11799  -8.16607  -39.07360 1.000 28.62380  ?  307 ALA A N    1 
ATOM   3622 C CA   . ALA A 1 226 ? 18.20063  -8.22233  -40.53163 1.000 35.23095  ?  307 ALA A CA   1 
ATOM   3623 C C    . ALA A 1 226 ? 19.12838  -7.14320  -41.08700 1.000 31.38802  ?  307 ALA A C    1 
ATOM   3624 O O    . ALA A 1 226 ? 19.96829  -7.40960  -41.95028 1.000 39.15249  ?  307 ALA A O    1 
ATOM   3625 C CB   . ALA A 1 226 ? 16.78515  -8.05941  -41.09258 1.000 36.35585  ?  307 ALA A CB   1 
ATOM   3626 H H    A ALA A 1 226 ? 17.18410  -7.95809  -38.72007 0.000 34.34856  ?  307 ALA A H    1 
ATOM   3627 D D    B ALA A 1 226 ? 17.18326  -7.95797  -38.72235 1.000 34.34856  ?  307 ALA A D    1 
ATOM   3628 H HA   . ALA A 1 226 ? 18.61009  -9.18415  -40.84041 1.000 42.27714  ?  307 ALA A HA   1 
ATOM   3629 H HB1  . ALA A 1 226 ? 16.37904  -7.10441  -40.75917 1.000 43.62702  ?  307 ALA A HB1  1 
ATOM   3630 H HB2  . ALA A 1 226 ? 16.82984  -8.08452  -42.18138 1.000 43.62702  ?  307 ALA A HB2  1 
ATOM   3631 H HB3  . ALA A 1 226 ? 16.16246  -8.87601  -40.72719 1.000 43.62702  ?  307 ALA A HB3  1 
ATOM   3632 N N    . SER A 1 227 ? 18.96841  -5.91394  -40.62105 1.000 29.25211  ?  308 SER A N    1 
ATOM   3633 C CA   . SER A 1 227 ? 19.82124  -4.79074  -40.94864 1.000 28.48321  ?  308 SER A CA   1 
ATOM   3634 C C    . SER A 1 227 ? 19.97778  -4.00571  -39.65844 1.000 22.30456  ?  308 SER A C    1 
ATOM   3635 O O    . SER A 1 227 ? 19.07536  -4.03988  -38.80517 1.000 24.31724  ?  308 SER A O    1 
ATOM   3636 C CB   . SER A 1 227 ? 19.18725  -3.86543  -41.99792 1.000 27.38466  ?  308 SER A CB   1 
ATOM   3637 O OG   . SER A 1 227 ? 17.94647  -3.35512  -41.53638 1.000 37.79847  ?  308 SER A OG   1 
ATOM   3638 H H    A SER A 1 227 ? 18.21677  -5.65568  -39.98172 0.010 35.10253  ?  308 SER A H    1 
ATOM   3639 D D    B SER A 1 227 ? 18.21600  -5.65787  -39.98175 0.990 35.10253  ?  308 SER A D    1 
ATOM   3640 H HA   . SER A 1 227 ? 20.78086  -5.12882  -41.33969 1.000 34.17985  ?  308 SER A HA   1 
ATOM   3641 H HB2  . SER A 1 227 ? 19.86344  -3.03279  -42.19176 1.000 32.86160  ?  308 SER A HB2  1 
ATOM   3642 H HB3  . SER A 1 227 ? 19.01960  -4.43073  -42.91467 1.000 32.86160  ?  308 SER A HB3  1 
ATOM   3643 N N    . PRO A 1 228 ? 21.09071  -3.29531  -39.48433 1.000 19.94416  ?  309 PRO A N    1 
ATOM   3644 C CA   . PRO A 1 228 ? 21.30817  -2.57947  -38.22255 1.000 19.22543  ?  309 PRO A CA   1 
ATOM   3645 C C    . PRO A 1 228 ? 20.27539  -1.49611  -37.99766 1.000 22.57485  ?  309 PRO A C    1 
ATOM   3646 O O    . PRO A 1 228 ? 19.89425  -0.76170  -38.91086 1.000 22.49354  ?  309 PRO A O    1 
ATOM   3647 C CB   . PRO A 1 228 ? 22.71547  -1.99577  -38.37222 1.000 19.80808  ?  309 PRO A CB   1 
ATOM   3648 C CG   . PRO A 1 228 ? 23.38164  -2.85876  -39.42932 1.000 26.61379  ?  309 PRO A CG   1 
ATOM   3649 C CD   . PRO A 1 228 ? 22.30076  -3.28402  -40.33534 1.000 25.15609  ?  309 PRO A CD   1 
ATOM   3650 H HA   . PRO A 1 228 ? 21.28603  -3.27901  -37.38694 1.000 23.07052  ?  309 PRO A HA   1 
ATOM   3651 H HB2  . PRO A 1 228 ? 22.65487  -0.95694  -38.69667 1.000 23.76970  ?  309 PRO A HB2  1 
ATOM   3652 H HB3  . PRO A 1 228 ? 23.24761  -2.05946  -37.42308 1.000 23.76970  ?  309 PRO A HB3  1 
ATOM   3653 H HG2  . PRO A 1 228 ? 24.12821  -2.27334  -39.96598 1.000 31.93654  ?  309 PRO A HG2  1 
ATOM   3654 H HG3  . PRO A 1 228 ? 23.85266  -3.72118  -38.95765 1.000 31.93654  ?  309 PRO A HG3  1 
ATOM   3655 H HD2  . PRO A 1 228 ? 22.18629  -2.57455  -41.15487 1.000 30.18730  ?  309 PRO A HD2  1 
ATOM   3656 H HD3  . PRO A 1 228 ? 22.50111  -4.28017  -40.72986 1.000 30.18730  ?  309 PRO A HD3  1 
ATOM   3657 N N    . ASP A 1 229 ? 19.82205  -1.40077  -36.75710 1.000 18.12742  ?  310 ASP A N    1 
ATOM   3658 C CA   . ASP A 1 229 ? 18.97342  -0.30029  -36.33627 1.000 18.48502  ?  310 ASP A CA   1 
ATOM   3659 C C    . ASP A 1 229 ? 19.79955  0.97834   -36.38511 1.000 19.30618  ?  310 ASP A C    1 
ATOM   3660 O O    . ASP A 1 229 ? 20.96478  0.97778   -35.97386 1.000 16.97943  ?  310 ASP A O    1 
ATOM   3661 C CB   . ASP A 1 229 ? 18.55363  -0.60650  -34.88411 1.000 18.01745  ?  310 ASP A CB   1 
ATOM   3662 C CG   . ASP A 1 229 ? 17.48786  0.32213   -34.33567 1.000 21.31443  ?  310 ASP A CG   1 
ATOM   3663 O OD1  . ASP A 1 229 ? 17.56119  1.54887   -34.54649 1.000 20.42685  ?  310 ASP A OD1  1 
ATOM   3664 O OD2  . ASP A 1 229 ? 16.61984  -0.19220  -33.59851 1.000 19.46005  -1 310 ASP A OD2  1 
ATOM   3665 H H    A ASP A 1 229 ? 20.02482  -2.07178  -36.01614 0.100 21.75290  ?  310 ASP A H    1 
ATOM   3666 D D    B ASP A 1 229 ? 20.02353  -2.07053  -36.01465 0.900 21.75290  ?  310 ASP A D    1 
ATOM   3667 H HA   . ASP A 1 229 ? 18.09232  -0.16570  -36.96368 1.000 22.18203  ?  310 ASP A HA   1 
ATOM   3668 H HB2  . ASP A 1 229 ? 18.16015  -1.62211  -34.84150 1.000 21.62094  ?  310 ASP A HB2  1 
ATOM   3669 H HB3  . ASP A 1 229 ? 19.42993  -0.51896  -34.24182 1.000 21.62094  ?  310 ASP A HB3  1 
ATOM   3670 N N    . PRO A 1 230 ? 19.23501  2.07757   -36.91353 1.000 20.96975  ?  311 PRO A N    1 
ATOM   3671 C CA   . PRO A 1 230 ? 20.01946  3.31483   -37.04500 1.000 21.96725  ?  311 PRO A CA   1 
ATOM   3672 C C    . PRO A 1 230 ? 20.64822  3.79695   -35.75809 1.000 19.89601  ?  311 PRO A C    1 
ATOM   3673 O O    . PRO A 1 230 ? 21.67209  4.48124   -35.80180 1.000 21.49656  ?  311 PRO A O    1 
ATOM   3674 C CB   . PRO A 1 230 ? 18.99489  4.32609   -37.59534 1.000 22.57570  ?  311 PRO A CB   1 
ATOM   3675 C CG   . PRO A 1 230 ? 17.92819  3.51303   -38.20958 1.000 29.65575  ?  311 PRO A CG   1 
ATOM   3676 C CD   . PRO A 1 230 ? 17.89196  2.17469   -37.52460 1.000 21.65151  ?  311 PRO A CD   1 
ATOM   3677 H HA   . PRO A 1 230 ? 20.81035  3.16820   -37.78059 1.000 26.36070  ?  311 PRO A HA   1 
ATOM   3678 H HB2  . PRO A 1 230 ? 18.60002  4.93164   -36.77957 1.000 27.09084  ?  311 PRO A HB2  1 
ATOM   3679 H HB3  . PRO A 1 230 ? 19.47116  4.96613   -38.33804 1.000 27.09084  ?  311 PRO A HB3  1 
ATOM   3680 H HG2  . PRO A 1 230 ? 16.97414  4.02477   -38.08302 1.000 35.58690  ?  311 PRO A HG2  1 
ATOM   3681 H HG3  . PRO A 1 230 ? 18.14501  3.38549   -39.27016 1.000 35.58690  ?  311 PRO A HG3  1 
ATOM   3682 H HD2  . PRO A 1 230 ? 17.11426  2.14902   -36.76131 1.000 25.98181  ?  311 PRO A HD2  1 
ATOM   3683 H HD3  . PRO A 1 230 ? 17.73341  1.37264   -38.24549 1.000 25.98181  ?  311 PRO A HD3  1 
ATOM   3684 N N    . ILE A 1 231 ? 20.06215  3.45755   -34.59577 1.000 18.67342  ?  312 ILE A N    1 
ATOM   3685 C CA   . ILE A 1 231 ? 20.62236  3.93939   -33.32637 1.000 17.65785  ?  312 ILE A CA   1 
ATOM   3686 C C    . ILE A 1 231 ? 21.99335  3.35169   -33.04808 1.000 15.25424  ?  312 ILE A C    1 
ATOM   3687 O O    . ILE A 1 231 ? 22.73158  3.84593   -32.19890 1.000 17.65567  ?  312 ILE A O    1 
ATOM   3688 C CB   . ILE A 1 231 ? 19.67794  3.62201   -32.14555 1.000 21.13513  ?  312 ILE A CB   1 
ATOM   3689 C CG1  . ILE A 1 231 ? 19.60188  2.09774   -31.92790 1.000 19.91556  ?  312 ILE A CG1  1 
ATOM   3690 C CG2  . ILE A 1 231 ? 18.31490  4.29473   -32.38511 1.000 21.04037  ?  312 ILE A CG2  1 
ATOM   3691 C CD1  . ILE A 1 231 ? 18.48987  1.62817   -31.01889 1.000 23.53251  ?  312 ILE A CD1  1 
ATOM   3692 H H    A ILE A 1 231 ? 19.23099  2.87315   -34.50599 0.000 22.40811  ?  312 ILE A H    1 
ATOM   3693 D D    B ILE A 1 231 ? 19.23107  2.87334   -34.50404 1.000 22.40811  ?  312 ILE A D    1 
ATOM   3694 H HA   . ILE A 1 231 ? 20.71942  5.02159   -33.41302 1.000 21.18942  ?  312 ILE A HA   1 
ATOM   3695 H HB   . ILE A 1 231 ? 20.06839  4.03606   -31.21592 1.000 25.36216  ?  312 ILE A HB   1 
ATOM   3696 H HG12 . ILE A 1 231 ? 19.45381  1.61955   -32.89615 1.000 23.89868  ?  312 ILE A HG12 1 
ATOM   3697 H HG13 . ILE A 1 231 ? 20.54264  1.76624   -31.48838 1.000 23.89868  ?  312 ILE A HG13 1 
ATOM   3698 H HG21 . ILE A 1 231 ? 17.61758  3.96833   -31.61355 1.000 25.24844  ?  312 ILE A HG21 1 
ATOM   3699 H HG22 . ILE A 1 231 ? 18.44016  5.37654   -32.33936 1.000 25.24844  ?  312 ILE A HG22 1 
ATOM   3700 H HG23 . ILE A 1 231 ? 17.94394  4.00474   -33.36817 1.000 25.24844  ?  312 ILE A HG23 1 
ATOM   3701 H HD11 . ILE A 1 231 ? 18.58041  2.13333   -30.05726 1.000 28.23902  ?  312 ILE A HD11 1 
ATOM   3702 H HD12 . ILE A 1 231 ? 17.53091  1.87020   -31.47706 1.000 28.23902  ?  312 ILE A HD12 1 
ATOM   3703 H HD13 . ILE A 1 231 ? 18.57483  0.55016   -30.88190 1.000 28.23902  ?  312 ILE A HD13 1 
ATOM   3704 N N    . THR A 1 232 ? 22.36099  2.29347   -33.76588 1.000 16.33852  ?  313 THR A N    1 
ATOM   3705 C CA   . THR A 1 232 ? 23.58784  1.57201   -33.47800 1.000 16.23854  ?  313 THR A CA   1 
ATOM   3706 C C    . THR A 1 232 ? 24.81512  2.07949   -34.23340 1.000 15.44909  ?  313 THR A C    1 
ATOM   3707 O O    . THR A 1 232 ? 25.88318  1.49591   -34.08412 1.000 16.64400  ?  313 THR A O    1 
ATOM   3708 C CB   . THR A 1 232 ? 23.44004  0.07581   -33.78507 1.000 17.31522  ?  313 THR A CB   1 
ATOM   3709 O OG1  . THR A 1 232 ? 23.32796  -0.15004  -35.19974 1.000 17.07971  ?  313 THR A OG1  1 
ATOM   3710 C CG2  . THR A 1 232 ? 22.25323  -0.53328  -33.09537 1.000 16.39545  ?  313 THR A CG2  1 
ATOM   3711 H H    A THR A 1 232 ? 21.82809  1.91684   -34.54982 0.730 19.60622  ?  313 THR A H    1 
ATOM   3712 D D    B THR A 1 232 ? 21.82723  1.91772   -34.54966 0.270 19.60622  ?  313 THR A D    1 
ATOM   3713 H HA   . THR A 1 232 ? 23.76461  1.69965   -32.41003 1.000 19.48624  ?  313 THR A HA   1 
ATOM   3714 H HB   . THR A 1 232 ? 24.33478  -0.42087  -33.40976 1.000 20.77827  ?  313 THR A HB   1 
ATOM   3715 H HG1  A THR A 1 232 ? 22.39720  -0.03629  -35.48462 0.030 20.49565  ?  313 THR A HG1  1 
ATOM   3716 D DG1  B THR A 1 232 ? 22.44695  0.13946   -35.51662 0.970 20.49565  ?  313 THR A DG1  1 
ATOM   3717 H HG21 . THR A 1 232 ? 22.03012  -1.50828  -33.52861 1.000 19.67453  ?  313 THR A HG21 1 
ATOM   3718 H HG22 . THR A 1 232 ? 22.46282  -0.65784  -32.03299 1.000 19.67453  ?  313 THR A HG22 1 
ATOM   3719 H HG23 . THR A 1 232 ? 21.38288  0.11267   -33.21087 1.000 19.67453  ?  313 THR A HG23 1 
ATOM   3720 N N    . GLN A 1 233 ? 24.70025  3.15422   -35.03821 1.000 16.22700  ?  314 GLN A N    1 
ATOM   3721 C CA   . GLN A 1 233 ? 25.82107  3.55618   -35.88462 1.000 16.74683  ?  314 GLN A CA   1 
ATOM   3722 C C    . GLN A 1 233 ? 27.06697  3.78304   -35.06495 1.000 15.89833  ?  314 GLN A C    1 
ATOM   3723 O O    . GLN A 1 233 ? 27.03238  4.40938   -34.00829 1.000 17.32987  ?  314 GLN A O    1 
ATOM   3724 C CB   . GLN A 1 233 ? 25.49705  4.85708   -36.59448 1.000 21.50862  ?  314 GLN A CB   1 
ATOM   3725 C CG   . GLN A 1 233 ? 24.57113  4.67715   -37.71864 1.000 32.85514  ?  314 GLN A CG   1 
ATOM   3726 C CD   . GLN A 1 233 ? 24.17309  6.00553   -38.30735 1.000 42.27364  ?  314 GLN A CD   1 
ATOM   3727 O OE1  . GLN A 1 233 ? 24.92702  6.59575   -39.08732 1.000 52.14686  ?  314 GLN A OE1  1 
ATOM   3728 N NE2  . GLN A 1 233 ? 22.99250  6.51109   -37.90175 1.000 41.19594  ?  314 GLN A NE2  1 
ATOM   3729 H H    A GLN A 1 233 ? 23.86949  3.74071   -35.11744 0.650 19.47240  ?  314 GLN A H    1 
ATOM   3730 D D    B GLN A 1 233 ? 23.87018  3.74155   -35.11843 0.350 19.47240  ?  314 GLN A D    1 
ATOM   3731 H HA   . GLN A 1 233 ? 25.99881  2.76418   -36.61212 1.000 20.09619  ?  314 GLN A HA   1 
ATOM   3732 H HB2  . GLN A 1 233 ? 25.03563  5.54302   -35.88407 1.000 25.81034  ?  314 GLN A HB2  1 
ATOM   3733 H HB3  . GLN A 1 233 ? 26.41970  5.28797   -36.98325 1.000 25.81034  ?  314 GLN A HB3  1 
ATOM   3734 H HG2  . GLN A 1 233 ? 25.05481  4.08573   -38.49605 1.000 39.42617  ?  314 GLN A HG2  1 
ATOM   3735 H HG3  . GLN A 1 233 ? 23.67135  4.17020   -37.37007 1.000 39.42617  ?  314 GLN A HG3  1 
ATOM   3736 N N    . GLY A 1 234 ? 28.20182  3.28190   -35.56975 1.000 16.62133  ?  315 GLY A N    1 
ATOM   3737 C CA   . GLY A 1 234 ? 29.46431  3.33840   -34.89454 1.000 16.88115  ?  315 GLY A CA   1 
ATOM   3738 C C    . GLY A 1 234 ? 29.85461  2.06532   -34.15888 1.000 15.46406  ?  315 GLY A C    1 
ATOM   3739 O O    . GLY A 1 234 ? 31.01915  1.90107   -33.81957 1.000 17.93955  ?  315 GLY A O    1 
ATOM   3740 H H    A GLY A 1 234 ? 28.25671  2.81931   -36.47716 0.120 19.94559  ?  315 GLY A H    1 
ATOM   3741 D D    B GLY A 1 234 ? 28.25457  2.81964   -36.47746 0.880 19.94559  ?  315 GLY A D    1 
ATOM   3742 H HA2  . GLY A 1 234 ? 30.24284  3.55044   -35.62736 1.000 20.25738  ?  315 GLY A HA2  1 
ATOM   3743 H HA3  . GLY A 1 234 ? 29.43393  4.14756   -34.16485 1.000 20.25738  ?  315 GLY A HA3  1 
ATOM   3744 N N    . ASN A 1 235 ? 28.87061  1.20742   -33.85519 1.000 16.64849  ?  316 ASN A N    1 
ATOM   3745 C CA   . ASN A 1 235 ? 29.11021  -0.03099  -33.11936 1.000 16.55932  ?  316 ASN A CA   1 
ATOM   3746 C C    . ASN A 1 235 ? 28.91948  -1.18060  -34.09379 1.000 13.19683  ?  316 ASN A C    1 
ATOM   3747 O O    . ASN A 1 235 ? 27.79586  -1.43897  -34.53590 1.000 16.11919  ?  316 ASN A O    1 
ATOM   3748 C CB   . ASN A 1 235 ? 28.13255  -0.15558  -31.95152 1.000 14.38427  ?  316 ASN A CB   1 
ATOM   3749 C CG   . ASN A 1 235 ? 28.49760  -1.28946  -31.03528 1.000 13.97929  ?  316 ASN A CG   1 
ATOM   3750 O OD1  . ASN A 1 235 ? 29.29755  -2.14153  -31.34613 1.000 14.60732  ?  316 ASN A OD1  1 
ATOM   3751 N ND2  . ASN A 1 235 ? 27.84574  -1.33031  -29.88538 1.000 15.51641  ?  316 ASN A ND2  1 
ATOM   3752 H H    A ASN A 1 235 ? 27.89290  1.34851   -34.10931 0.730 19.97819  ?  316 ASN A H    1 
ATOM   3753 D D    B ASN A 1 235 ? 27.89306  1.34910   -34.10961 0.270 19.97819  ?  316 ASN A D    1 
ATOM   3754 H HA   . ASN A 1 235 ? 30.12131  -0.05021  -32.71267 1.000 19.87119  ?  316 ASN A HA   1 
ATOM   3755 H HB2  . ASN A 1 235 ? 28.14447  0.76818   -31.37304 1.000 17.26112  ?  316 ASN A HB2  1 
ATOM   3756 H HB3  . ASN A 1 235 ? 27.13078  -0.33938  -32.33981 1.000 17.26112  ?  316 ASN A HB3  1 
ATOM   3757 N N    . PRO A 1 236 ? 29.98689  -1.91436  -34.42746 1.000 15.52596  ?  317 PRO A N    1 
ATOM   3758 C CA   . PRO A 1 236 ? 29.81589  -3.09557  -35.29097 1.000 15.65543  ?  317 PRO A CA   1 
ATOM   3759 C C    . PRO A 1 236 ? 29.01022  -4.20652  -34.65436 1.000 15.53109  ?  317 PRO A C    1 
ATOM   3760 O O    . PRO A 1 236 ? 28.49024  -5.07551  -35.35651 1.000 18.04719  ?  317 PRO A O    1 
ATOM   3761 C CB   . PRO A 1 236 ? 31.26086  -3.55699  -35.55142 1.000 17.64098  ?  317 PRO A CB   1 
ATOM   3762 C CG   . PRO A 1 236 ? 32.03569  -3.07291  -34.43009 1.000 22.05573  ?  317 PRO A CG   1 
ATOM   3763 C CD   . PRO A 1 236 ? 31.37830  -1.75522  -33.98258 1.000 16.07217  ?  317 PRO A CD   1 
ATOM   3764 H HA   . PRO A 1 236 ? 29.34824  -2.79824  -36.22958 1.000 18.78651  ?  317 PRO A HA   1 
ATOM   3765 H HB2  . PRO A 1 236 ? 31.29527  -4.64515  -35.60463 1.000 21.16917  ?  317 PRO A HB2  1 
ATOM   3766 H HB3  . PRO A 1 236 ? 31.62144  -3.12648  -36.48563 1.000 21.16917  ?  317 PRO A HB3  1 
ATOM   3767 H HG2  . PRO A 1 236 ? 32.01022  -3.80711  -33.62485 1.000 26.46687  ?  317 PRO A HG2  1 
ATOM   3768 H HG3  . PRO A 1 236 ? 33.06487  -2.90052  -34.74499 1.000 26.46687  ?  317 PRO A HG3  1 
ATOM   3769 H HD2  . PRO A 1 236 ? 31.43049  -1.64200  -32.89973 1.000 19.28660  ?  317 PRO A HD2  1 
ATOM   3770 H HD3  . PRO A 1 236 ? 31.84770  -0.90061  -34.46982 1.000 19.28660  ?  317 PRO A HD3  1 
ATOM   3771 N N    . ASN A 1 237 ? 28.88196  -4.18835  -33.32913 1.000 14.29601  ?  318 ASN A N    1 
ATOM   3772 C CA   . ASN A 1 237 ? 28.10713  -5.19842  -32.60373 1.000 15.48527  ?  318 ASN A CA   1 
ATOM   3773 C C    . ASN A 1 237 ? 26.71232  -4.65661  -32.38471 1.000 13.78037  ?  318 ASN A C    1 
ATOM   3774 O O    . ASN A 1 237 ? 26.37540  -4.15806  -31.31122 1.000 15.75799  ?  318 ASN A O    1 
ATOM   3775 C CB   . ASN A 1 237 ? 28.83234  -5.54964  -31.31943 1.000 14.42175  ?  318 ASN A CB   1 
ATOM   3776 C CG   . ASN A 1 237 ? 30.15142  -6.22647  -31.60170 1.000 15.09181  ?  318 ASN A CG   1 
ATOM   3777 O OD1  . ASN A 1 237 ? 30.25689  -6.99102  -32.56982 1.000 17.97868  ?  318 ASN A OD1  1 
ATOM   3778 N ND2  . ASN A 1 237 ? 31.14747  -5.95148  -30.81530 1.000 17.21295  ?  318 ASN A ND2  1 
ATOM   3779 H H    A ASN A 1 237 ? 29.30443  -3.48378  -32.72455 1.000 17.15521  ?  318 ASN A H    1 
ATOM   3780 D D    B ASN A 1 237 ? 29.30477  -3.48340  -32.72524 0.000 17.15521  ?  318 ASN A D    1 
ATOM   3781 H HA   . ASN A 1 237 ? 28.00241  -6.10975  -33.19246 1.000 18.58233  ?  318 ASN A HA   1 
ATOM   3782 H HB2  . ASN A 1 237 ? 29.02742  -4.63855  -30.75378 1.000 17.30610  ?  318 ASN A HB2  1 
ATOM   3783 H HB3  . ASN A 1 237 ? 28.21617  -6.22923  -30.73070 1.000 17.30610  ?  318 ASN A HB3  1 
ATOM   3784 H HD21 A ASN A 1 237 ? 32.05615  -6.38770  -30.97156 0.050 20.65554  ?  318 ASN A HD21 1 
ATOM   3785 D DD21 B ASN A 1 237 ? 32.05615  -6.38770  -30.97156 0.950 20.65554  ?  318 ASN A DD21 1 
ATOM   3786 H HD22 A ASN A 1 237 ? 31.02120  -5.29925  -30.04132 0.100 20.65554  ?  318 ASN A HD22 1 
ATOM   3787 D DD22 B ASN A 1 237 ? 31.02120  -5.29925  -30.04132 0.900 20.65554  ?  318 ASN A DD22 1 
ATOM   3788 N N    . TYR A 1 238 ? 25.88775  -4.72903  -33.42522 1.000 14.46323  ?  319 TYR A N    1 
ATOM   3789 C CA   . TYR A 1 238 ? 24.63570  -3.99687  -33.48292 1.000 14.68603  ?  319 TYR A CA   1 
ATOM   3790 C C    . TYR A 1 238 ? 23.44767  -4.81297  -32.98402 1.000 14.43649  ?  319 TYR A C    1 
ATOM   3791 O O    . TYR A 1 238 ? 22.31769  -4.30088  -32.93079 1.000 15.70536  ?  319 TYR A O    1 
ATOM   3792 C CB   . TYR A 1 238 ? 24.33956  -3.45186  -34.89770 1.000 15.18501  ?  319 TYR A CB   1 
ATOM   3793 C CG   . TYR A 1 238 ? 24.43855  -4.49838  -35.99377 1.000 15.65644  ?  319 TYR A CG   1 
ATOM   3794 C CD1  . TYR A 1 238 ? 23.39254  -5.35990  -36.26094 1.000 17.21525  ?  319 TYR A CD1  1 
ATOM   3795 C CD2  . TYR A 1 238 ? 25.58383  -4.60085  -36.76668 1.000 18.70105  ?  319 TYR A CD2  1 
ATOM   3796 C CE1  . TYR A 1 238 ? 23.49109  -6.33955  -37.27602 1.000 20.77011  ?  319 TYR A CE1  1 
ATOM   3797 C CE2  . TYR A 1 238 ? 25.68916  -5.56381  -37.75823 1.000 21.45891  ?  319 TYR A CE2  1 
ATOM   3798 C CZ   . TYR A 1 238 ? 24.66033  -6.41249  -38.00695 1.000 21.49495  ?  319 TYR A CZ   1 
ATOM   3799 O OH   . TYR A 1 238 ? 24.79132  -7.35561  -39.01023 1.000 24.07781  ?  319 TYR A OH   1 
ATOM   3800 H H    A TYR A 1 238 ? 26.06635  -5.29643  -34.25382 0.850 17.35588  ?  319 TYR A H    1 
ATOM   3801 D D    B TYR A 1 238 ? 26.06745  -5.29682  -34.25331 0.150 17.35588  ?  319 TYR A D    1 
ATOM   3802 H HA   . TYR A 1 238 ? 24.74596  -3.12257  -32.84141 1.000 17.62324  ?  319 TYR A HA   1 
ATOM   3803 H HB2  . TYR A 1 238 ? 23.32638  -3.05020  -34.91277 1.000 18.22202  ?  319 TYR A HB2  1 
ATOM   3804 H HB3  . TYR A 1 238 ? 25.05664  -2.66331  -35.12590 1.000 18.22202  ?  319 TYR A HB3  1 
ATOM   3805 H HD1  . TYR A 1 238 ? 22.48269  -5.28399  -35.68404 1.000 20.65831  ?  319 TYR A HD1  1 
ATOM   3806 H HD2  . TYR A 1 238 ? 26.40547  -3.92143  -36.59436 1.000 22.44126  ?  319 TYR A HD2  1 
ATOM   3807 H HE1  . TYR A 1 238 ? 22.67163  -7.01437  -37.47477 1.000 24.92413  ?  319 TYR A HE1  1 
ATOM   3808 H HE2  . TYR A 1 238 ? 26.59759  -5.63907  -38.33745 1.000 25.75069  ?  319 TYR A HE2  1 
ATOM   3809 N N    . ASP A 1 239 ? 23.67831  -6.06464  -32.60522 1.000 13.14066  ?  320 ASP A N    1 
ATOM   3810 C CA   . ASP A 1 239 ? 22.64930  -6.93607  -32.05333 1.000 13.59208  ?  320 ASP A CA   1 
ATOM   3811 C C    . ASP A 1 239 ? 23.31295  -7.85514  -31.02750 1.000 12.31294  ?  320 ASP A C    1 
ATOM   3812 O O    . ASP A 1 239 ? 24.52904  -7.84894  -30.84239 1.000 12.70567  ?  320 ASP A O    1 
ATOM   3813 C CB   . ASP A 1 239 ? 21.89474  -7.69339  -33.15159 1.000 13.72267  ?  320 ASP A CB   1 
ATOM   3814 C CG   . ASP A 1 239 ? 22.78121  -8.56055  -34.03213 1.000 16.58046  ?  320 ASP A CG   1 
ATOM   3815 O OD1  . ASP A 1 239 ? 23.91567  -8.84470  -33.62636 1.000 15.89739  ?  320 ASP A OD1  1 
ATOM   3816 O OD2  . ASP A 1 239 ? 22.27653  -8.91741  -35.13486 1.000 17.71341  -1 320 ASP A OD2  1 
ATOM   3817 H H    A ASP A 1 239 ? 24.59092  -6.51563  -32.66968 1.000 15.76879  ?  320 ASP A H    1 
ATOM   3818 D D    B ASP A 1 239 ? 24.59104  -6.51535  -32.66981 0.000 15.76879  ?  320 ASP A D    1 
ATOM   3819 H HA   . ASP A 1 239 ? 21.89775  -6.35012  -31.52424 1.000 16.31050  ?  320 ASP A HA   1 
ATOM   3820 H HB2  . ASP A 1 239 ? 21.15694  -8.34451  -32.68277 1.000 16.46720  ?  320 ASP A HB2  1 
ATOM   3821 H HB3  . ASP A 1 239 ? 21.39670  -6.96898  -33.79602 1.000 16.46720  ?  320 ASP A HB3  1 
ATOM   3822 N N    . GLU A 1 240 ? 22.46826  -8.62287  -30.33404 1.000 11.33077  ?  321 GLU A N    1 
ATOM   3823 C CA   . GLU A 1 240 ? 22.99926  -9.39212  -29.21189 1.000 11.26566  ?  321 GLU A CA   1 
ATOM   3824 C C    . GLU A 1 240 ? 23.89484  -10.53157 -29.69455 1.000 11.36892  ?  321 GLU A C    1 
ATOM   3825 O O    . GLU A 1 240 ? 24.87324  -10.86929 -29.02756 1.000 12.41677  ?  321 GLU A O    1 
ATOM   3826 C CB   . GLU A 1 240 ? 21.87783  -9.90513  -28.31604 1.000 12.40700  ?  321 GLU A CB   1 
ATOM   3827 C CG   . GLU A 1 240 ? 21.10436  -8.77575  -27.60283 1.000 10.29503  ?  321 GLU A CG   1 
ATOM   3828 C CD   . GLU A 1 240 ? 21.97311  -7.93979  -26.71190 1.000 12.34484  ?  321 GLU A CD   1 
ATOM   3829 O OE1  . GLU A 1 240 ? 22.57389  -8.46515  -25.75173 1.000 14.65315  ?  321 GLU A OE1  1 
ATOM   3830 O OE2  . GLU A 1 240 ? 22.16874  -6.74262  -27.01144 1.000 13.56388  -1 321 GLU A OE2  1 
ATOM   3831 H H    A GLU A 1 240 ? 21.46974  -8.72677  -30.51450 0.840 13.59693  ?  321 GLU A H    1 
ATOM   3832 D D    B GLU A 1 240 ? 21.46956  -8.72839  -30.51254 0.160 13.59693  ?  321 GLU A D    1 
ATOM   3833 H HA   . GLU A 1 240 ? 23.60786  -8.72739  -28.59882 1.000 13.51879  ?  321 GLU A HA   1 
ATOM   3834 H HB2  . GLU A 1 240 ? 21.16807  -10.46509 -28.92497 1.000 14.88840  ?  321 GLU A HB2  1 
ATOM   3835 H HB3  . GLU A 1 240 ? 22.30575  -10.55339 -27.55136 1.000 14.88840  ?  321 GLU A HB3  1 
ATOM   3836 H HG2  . GLU A 1 240 ? 20.66416  -8.11959  -28.35368 1.000 12.35403  ?  321 GLU A HG2  1 
ATOM   3837 H HG3  . GLU A 1 240 ? 20.32020  -9.21758  -26.98802 1.000 12.35403  ?  321 GLU A HG3  1 
ATOM   3838 N N    . ILE A 1 241 ? 23.61446  -11.12219 -30.86579 1.000 12.69375  ?  322 ILE A N    1 
ATOM   3839 C CA   . ILE A 1 241 ? 24.47558  -12.22416 -31.29617 1.000 12.66517  ?  322 ILE A CA   1 
ATOM   3840 C C    . ILE A 1 241 ? 25.88488  -11.71531 -31.60570 1.000 12.19240  ?  322 ILE A C    1 
ATOM   3841 O O    . ILE A 1 241 ? 26.88183  -12.38291 -31.31942 1.000 13.11080  ?  322 ILE A O    1 
ATOM   3842 C CB   . ILE A 1 241 ? 23.82756  -13.02968 -32.44628 1.000 15.22436  ?  322 ILE A CB   1 
ATOM   3843 C CG1  . ILE A 1 241 ? 24.56086  -14.33968 -32.65973 1.000 20.07845  ?  322 ILE A CG1  1 
ATOM   3844 C CG2  . ILE A 1 241 ? 23.90008  -12.28750 -33.73523 1.000 18.05648  ?  322 ILE A CG2  1 
ATOM   3845 C CD1  . ILE A 1 241 ? 24.34161  -15.30587 -31.58926 1.000 28.01291  ?  322 ILE A CD1  1 
ATOM   3846 H H    A ILE A 1 241 ? 22.84983  -10.87528 -31.49411 1.000 15.23251  ?  322 ILE A H    1 
ATOM   3847 D D    B ILE A 1 241 ? 22.85049  -10.87693 -31.49555 0.000 15.23251  ?  322 ILE A D    1 
ATOM   3848 H HA   . ILE A 1 241 ? 24.57676  -12.92929 -30.47115 1.000 15.19820  ?  322 ILE A HA   1 
ATOM   3849 H HB   . ILE A 1 241 ? 22.79043  -13.19851 -32.15655 1.000 18.26923  ?  322 ILE A HB   1 
ATOM   3850 H HG12 . ILE A 1 241 ? 24.21632  -14.78849 -33.59138 1.000 24.09415  ?  322 ILE A HG12 1 
ATOM   3851 H HG13 . ILE A 1 241 ? 25.63083  -14.13936 -32.71576 1.000 24.09415  ?  322 ILE A HG13 1 
ATOM   3852 H HG21 . ILE A 1 241 ? 23.83443  -11.21838 -33.53332 1.000 21.66778  ?  322 ILE A HG21 1 
ATOM   3853 H HG22 . ILE A 1 241 ? 24.84742  -12.51607 -34.22352 1.000 21.66778  ?  322 ILE A HG22 1 
ATOM   3854 H HG23 . ILE A 1 241 ? 23.07025  -12.59746 -34.37037 1.000 21.66778  ?  322 ILE A HG23 1 
ATOM   3855 H HD11 . ILE A 1 241 ? 25.24507  -15.90142 -31.45821 1.000 33.61550  ?  322 ILE A HD11 1 
ATOM   3856 H HD12 . ILE A 1 241 ? 24.11320  -14.76942 -30.66831 1.000 33.61550  ?  322 ILE A HD12 1 
ATOM   3857 H HD13 . ILE A 1 241 ? 23.50652  -15.95198 -31.85994 1.000 33.61550  ?  322 ILE A HD13 1 
ATOM   3858 N N    . HIS A 1 242 ? 26.01094  -10.51579 -32.17550 1.000 12.48752  ?  323 HIS A N    1 
ATOM   3859 C CA   . HIS A 1 242 ? 27.33969  -9.98423  -32.39563 1.000 12.19817  ?  323 HIS A CA   1 
ATOM   3860 C C    . HIS A 1 242 ? 28.07566  -9.74468  -31.08485 1.000 12.90471  ?  323 HIS A C    1 
ATOM   3861 O O    . HIS A 1 242 ? 29.26008  -10.01177 -30.96432 1.000 14.24405  ?  323 HIS A O    1 
ATOM   3862 C CB   . HIS A 1 242 ? 27.30358  -8.66290  -33.19603 1.000 14.58724  ?  323 HIS A CB   1 
ATOM   3863 C CG   . HIS A 1 242 ? 27.14060  -8.84248  -34.67507 1.000 15.40449  ?  323 HIS A CG   1 
ATOM   3864 N ND1  . HIS A 1 242 ? 25.92677  -9.09776  -35.25363 1.000 15.87394  ?  323 HIS A ND1  1 
ATOM   3865 C CD2  . HIS A 1 242 ? 28.04794  -8.78193  -35.68725 1.000 22.90844  ?  323 HIS A CD2  1 
ATOM   3866 C CE1  . HIS A 1 242 ? 26.08298  -9.21128  -36.57421 1.000 21.14006  ?  323 HIS A CE1  1 
ATOM   3867 N NE2  . HIS A 1 242 ? 27.36252  -9.02396  -36.85708 1.000 21.56317  ?  323 HIS A NE2  1 
ATOM   3868 H H    A HIS A 1 242 ? 25.24161  -9.91930  -32.48000 1.000 14.98503  ?  323 HIS A H    1 
ATOM   3869 D D    B HIS A 1 242 ? 25.24330  -9.91753  -32.48080 0.000 14.98503  ?  323 HIS A D    1 
ATOM   3870 H HA   . HIS A 1 242 ? 27.87852  -10.72562 -32.98564 1.000 14.63780  ?  323 HIS A HA   1 
ATOM   3871 H HB2  . HIS A 1 242 ? 26.46458  -8.06403  -32.84173 1.000 17.50468  ?  323 HIS A HB2  1 
ATOM   3872 H HB3  . HIS A 1 242 ? 28.23925  -8.12919  -33.02937 1.000 17.50468  ?  323 HIS A HB3  1 
ATOM   3873 H HD1  A HIS A 1 242 ? 25.04196  -9.18718  -34.75411 0.110 19.04873  ?  323 HIS A HD1  1 
ATOM   3874 D DD1  B HIS A 1 242 ? 25.04196  -9.18718  -34.75411 0.890 19.04873  ?  323 HIS A DD1  1 
ATOM   3875 H HD2  . HIS A 1 242 ? 29.10495  -8.58203  -35.59148 1.000 27.49013  ?  323 HIS A HD2  1 
ATOM   3876 H HE1  . HIS A 1 242 ? 25.30050  -9.41995  -37.28876 1.000 25.36808  ?  323 HIS A HE1  1 
ATOM   3877 N N    . TYR A 1 243 ? 27.39383  -9.15559  -30.09855 1.000 12.76343  ?  324 TYR A N    1 
ATOM   3878 C CA   . TYR A 1 243 ? 27.98111  -8.93491  -28.78329 1.000 12.68373  ?  324 TYR A CA   1 
ATOM   3879 C C    . TYR A 1 243 ? 28.45062  -10.24046 -28.15379 1.000 11.85719  ?  324 TYR A C    1 
ATOM   3880 O O    . TYR A 1 243 ? 29.59333  -10.35051 -27.72479 1.000 12.38882  ?  324 TYR A O    1 
ATOM   3881 C CB   . TYR A 1 243 ? 26.93592  -8.22154  -27.91163 1.000 13.18787  ?  324 TYR A CB   1 
ATOM   3882 C CG   . TYR A 1 243 ? 27.24782  -8.09095  -26.44667 1.000 11.00861  ?  324 TYR A CG   1 
ATOM   3883 C CD1  . TYR A 1 243 ? 28.53831  -7.87467  -25.98505 1.000 11.13381  ?  324 TYR A CD1  1 
ATOM   3884 C CD2  . TYR A 1 243 ? 26.21650  -8.13592  -25.52681 1.000 11.64134  ?  324 TYR A CD2  1 
ATOM   3885 C CE1  . TYR A 1 243 ? 28.79036  -7.72347  -24.62442 1.000 12.45474  ?  324 TYR A CE1  1 
ATOM   3886 C CE2  . TYR A 1 243 ? 26.46208  -7.99397  -24.16293 1.000 11.12204  ?  324 TYR A CE2  1 
ATOM   3887 C CZ   . TYR A 1 243 ? 27.74061  -7.80247  -23.73172 1.000 12.01627  ?  324 TYR A CZ   1 
ATOM   3888 O OH   . TYR A 1 243 ? 28.05617  -7.68317  -22.40942 1.000 13.13792  ?  324 TYR A OH   1 
ATOM   3889 H H    A TYR A 1 243 ? 26.43379  -8.82122  -30.18178 1.000 15.31612  ?  324 TYR A H    1 
ATOM   3890 D D    B TYR A 1 243 ? 26.43386  -8.82046  -30.17946 0.000 15.31612  ?  324 TYR A D    1 
ATOM   3891 H HA   . TYR A 1 243 ? 28.86422  -8.30113  -28.86425 1.000 15.22048  ?  324 TYR A HA   1 
ATOM   3892 H HB2  . TYR A 1 243 ? 26.80627  -7.21139  -28.30008 1.000 15.82544  ?  324 TYR A HB2  1 
ATOM   3893 H HB3  . TYR A 1 243 ? 25.99935  -8.77376  -27.98900 1.000 15.82544  ?  324 TYR A HB3  1 
ATOM   3894 H HD1  . TYR A 1 243 ? 29.35588  -7.82309  -26.68884 1.000 13.36057  ?  324 TYR A HD1  1 
ATOM   3895 H HD2  . TYR A 1 243 ? 25.20367  -8.28355  -25.87143 1.000 13.96961  ?  324 TYR A HD2  1 
ATOM   3896 H HE1  . TYR A 1 243 ? 29.79555  -7.54641  -24.27140 1.000 14.94569  ?  324 TYR A HE1  1 
ATOM   3897 H HE2  . TYR A 1 243 ? 25.64778  -8.03525  -23.45469 1.000 13.34644  ?  324 TYR A HE2  1 
ATOM   3898 H HH   A TYR A 1 243 ? 27.24543  -7.75480  -21.86356 0.030 15.76550  ?  324 TYR A HH   1 
ATOM   3899 D DH   B TYR A 1 243 ? 27.23898  -7.68305  -21.86849 0.970 15.76550  ?  324 TYR A DH   1 
ATOM   3900 N N    . ILE A 1 244 ? 27.57774  -11.24584 -28.13492 1.000 11.81799  ?  325 ILE A N    1 
ATOM   3901 C CA   . ILE A 1 244 ? 27.94039  -12.51986 -27.51299 1.000 12.58871  ?  325 ILE A CA   1 
ATOM   3902 C C    . ILE A 1 244 ? 29.06952  -13.20069 -28.26078 1.000 13.44797  ?  325 ILE A C    1 
ATOM   3903 O O    . ILE A 1 244 ? 29.99800  -13.72391 -27.64629 1.000 13.70042  ?  325 ILE A O    1 
ATOM   3904 C CB   . ILE A 1 244 ? 26.68691  -13.38754 -27.41724 1.000 12.52587  ?  325 ILE A CB   1 
ATOM   3905 C CG1  . ILE A 1 244 ? 25.73434  -12.74109 -26.39601 1.000 12.94305  ?  325 ILE A CG1  1 
ATOM   3906 C CG2  . ILE A 1 244 ? 27.05975  -14.81490 -27.04603 1.000 15.51935  ?  325 ILE A CG2  1 
ATOM   3907 C CD1  . ILE A 1 244 ? 24.38991  -13.32854 -26.38399 1.000 18.19936  ?  325 ILE A CD1  1 
ATOM   3908 H H    A ILE A 1 244 ? 26.63776  -11.21361 -28.52964 0.800 14.18159  ?  325 ILE A H    1 
ATOM   3909 D D    B ILE A 1 244 ? 26.63739  -11.21587 -28.52895 0.200 14.18159  ?  325 ILE A D    1 
ATOM   3910 H HA   . ILE A 1 244 ? 28.31821  -12.33804 -26.50686 1.000 15.10645  ?  325 ILE A HA   1 
ATOM   3911 H HB   . ILE A 1 244 ? 26.17981  -13.44144 -28.38059 1.000 15.03104  ?  325 ILE A HB   1 
ATOM   3912 H HG12 . ILE A 1 244 ? 26.15765  -12.85975 -25.39859 1.000 15.53166  ?  325 ILE A HG12 1 
ATOM   3913 H HG13 . ILE A 1 244 ? 25.63213  -11.68233 -26.63408 1.000 15.53166  ?  325 ILE A HG13 1 
ATOM   3914 H HG21 . ILE A 1 244 ? 26.15144  -15.41427 -26.98416 1.000 18.62323  ?  325 ILE A HG21 1 
ATOM   3915 H HG22 . ILE A 1 244 ? 27.72075  -15.21975 -27.81237 1.000 18.62323  ?  325 ILE A HG22 1 
ATOM   3916 H HG23 . ILE A 1 244 ? 27.56798  -14.80959 -26.08179 1.000 18.62323  ?  325 ILE A HG23 1 
ATOM   3917 H HD11 . ILE A 1 244 ? 23.90926  -13.13446 -27.34284 1.000 21.83923  ?  325 ILE A HD11 1 
ATOM   3918 H HD12 . ILE A 1 244 ? 24.47358  -14.40301 -26.22087 1.000 21.83923  ?  325 ILE A HD12 1 
ATOM   3919 H HD13 . ILE A 1 244 ? 23.81139  -12.87440 -25.57952 1.000 21.83923  ?  325 ILE A HD13 1 
ATOM   3920 N N    . ASN A 1 245 ? 29.03593  -13.18008 -29.60295 1.000 13.15416  ?  326 ASN A N    1 
ATOM   3921 C CA   . ASN A 1 245 ? 30.12353  -13.80037 -30.36573 1.000 14.20906  ?  326 ASN A CA   1 
ATOM   3922 C C    . ASN A 1 245 ? 31.45890  -13.12356 -30.11108 1.000 14.57179  ?  326 ASN A C    1 
ATOM   3923 O O    . ASN A 1 245 ? 32.51702  -13.76839 -30.20954 1.000 17.03767  ?  326 ASN A O    1 
ATOM   3924 C CB   . ASN A 1 245 ? 29.82065  -13.76273 -31.86373 1.000 16.19893  ?  326 ASN A CB   1 
ATOM   3925 C CG   . ASN A 1 245 ? 28.77289  -14.78279 -32.30519 1.000 19.69488  ?  326 ASN A CG   1 
ATOM   3926 O OD1  . ASN A 1 245 ? 28.46882  -15.72661 -31.58838 1.000 23.09030  ?  326 ASN A OD1  1 
ATOM   3927 N ND2  . ASN A 1 245 ? 28.24138  -14.60507 -33.53848 1.000 20.69306  ?  326 ASN A ND2  1 
ATOM   3928 H H    A ASN A 1 245 ? 28.29819  -12.75816 -30.16699 0.690 15.78500  ?  326 ASN A H    1 
ATOM   3929 D D    B ASN A 1 245 ? 28.29947  -12.75889 -30.16918 0.310 15.78500  ?  326 ASN A D    1 
ATOM   3930 H HA   . ASN A 1 245 ? 30.19465  -14.84131 -30.05032 1.000 17.05087  ?  326 ASN A HA   1 
ATOM   3931 H HB2  . ASN A 1 245 ? 29.44853  -12.77123 -32.12172 1.000 19.43872  ?  326 ASN A HB2  1 
ATOM   3932 H HB3  . ASN A 1 245 ? 30.73900  -13.97077 -32.41278 1.000 19.43872  ?  326 ASN A HB3  1 
ATOM   3933 N N    . ALA A 1 246 ? 31.44782  -11.83112 -29.77671 1.000 13.39376  ?  327 ALA A N    1 
ATOM   3934 C CA   . ALA A 1 246 ? 32.67300  -11.11826 -29.51444 1.000 14.14657  ?  327 ALA A CA   1 
ATOM   3935 C C    . ALA A 1 246 ? 33.14512  -11.30041 -28.08682 1.000 15.08342  ?  327 ALA A C    1 
ATOM   3936 O O    . ALA A 1 246 ? 34.34535  -11.32442 -27.83159 1.000 17.98261  ?  327 ALA A O    1 
ATOM   3937 C CB   . ALA A 1 246 ? 32.44298  -9.62463  -29.80687 1.000 15.86356  ?  327 ALA A CB   1 
ATOM   3938 H H    A ALA A 1 246 ? 30.60526  -11.26393 -29.68294 0.940 16.07251  ?  327 ALA A H    1 
ATOM   3939 D D    B ALA A 1 246 ? 30.60634  -11.26239 -29.68248 0.060 16.07251  ?  327 ALA A D    1 
ATOM   3940 H HA   . ALA A 1 246 ? 33.46139  -11.49216 -30.16769 1.000 16.97588  ?  327 ALA A HA   1 
ATOM   3941 H HB1  . ALA A 1 246 ? 32.22630  -9.50000  -30.86782 1.000 19.03627  ?  327 ALA A HB1  1 
ATOM   3942 H HB2  . ALA A 1 246 ? 31.60070  -9.27208  -29.21157 1.000 19.03627  ?  327 ALA A HB2  1 
ATOM   3943 H HB3  . ALA A 1 246 ? 33.34283  -9.06876  -29.54347 1.000 19.03627  ?  327 ALA A HB3  1 
ATOM   3944 N N    . LEU A 1 247 ? 32.23086  -11.41103 -27.11702 1.000 13.90476  ?  328 LEU A N    1 
ATOM   3945 C CA   . LEU A 1 247 ? 32.63401  -11.50905 -25.72463 1.000 13.29958  ?  328 LEU A CA   1 
ATOM   3946 C C    . LEU A 1 247 ? 32.97973  -12.94228 -25.31637 1.000 14.18311  ?  328 LEU A C    1 
ATOM   3947 O O    . LEU A 1 247 ? 33.91127  -13.14564 -24.53280 1.000 14.76038  ?  328 LEU A O    1 
ATOM   3948 C CB   . LEU A 1 247 ? 31.50292  -10.96176 -24.84260 1.000 13.30974  ?  328 LEU A CB   1 
ATOM   3949 C CG   . LEU A 1 247 ? 31.77579  -10.95500 -23.35008 1.000 14.51290  ?  328 LEU A CG   1 
ATOM   3950 C CD1  . LEU A 1 247 ? 32.96096  -10.07733 -23.00447 1.000 18.01574  ?  328 LEU A CD1  1 
ATOM   3951 C CD2  . LEU A 1 247 ? 30.53316  -10.51052 -22.59641 1.000 14.58181  ?  328 LEU A CD2  1 
ATOM   3952 H H    A LEU A 1 247 ? 31.22231  -11.43461 -27.26762 1.000 16.68571  ?  328 LEU A H    1 
ATOM   3953 D D    B LEU A 1 247 ? 31.22201  -11.43479 -27.26554 0.000 16.68571  ?  328 LEU A D    1 
ATOM   3954 H HA   . LEU A 1 247 ? 33.53125  -10.90913 -25.57244 1.000 15.95949  ?  328 LEU A HA   1 
ATOM   3955 H HB2  . LEU A 1 247 ? 31.30602  -9.93195  -25.14064 1.000 15.97168  ?  328 LEU A HB2  1 
ATOM   3956 H HB3  . LEU A 1 247 ? 30.61590  -11.57353 -25.00703 1.000 15.97168  ?  328 LEU A HB3  1 
ATOM   3957 H HG   . LEU A 1 247 ? 32.02893  -11.96741 -23.03537 1.000 17.41548  ?  328 LEU A HG   1 
ATOM   3958 H HD11 . LEU A 1 247 ? 33.71414  -10.17403 -23.78644 1.000 21.61888  ?  328 LEU A HD11 1 
ATOM   3959 H HD12 . LEU A 1 247 ? 32.62759  -9.04186  -22.93550 1.000 21.61888  ?  328 LEU A HD12 1 
ATOM   3960 H HD13 . LEU A 1 247 ? 33.37415  -10.39925 -22.04857 1.000 21.61888  ?  328 LEU A HD13 1 
ATOM   3961 H HD21 . LEU A 1 247 ? 30.71365  -9.52660  -22.16349 1.000 17.49817  ?  328 LEU A HD21 1 
ATOM   3962 H HD22 . LEU A 1 247 ? 29.69476  -10.46273 -23.29133 1.000 17.49817  ?  328 LEU A HD22 1 
ATOM   3963 H HD23 . LEU A 1 247 ? 30.32059  -11.23087 -21.80647 1.000 17.49817  ?  328 LEU A HD23 1 
ATOM   3964 N N    . ALA A 1 248 ? 32.23304  -13.91612 -25.81893 1.000 14.41651  ?  329 ALA A N    1 
ATOM   3965 C CA   . ALA A 1 248 ? 32.42316  -15.29233 -25.35727 1.000 15.18319  ?  329 ALA A CA   1 
ATOM   3966 C C    . ALA A 1 248 ? 33.86217  -15.77957 -25.49395 1.000 15.68288  ?  329 ALA A C    1 
ATOM   3967 O O    . ALA A 1 248 ? 34.37436  -16.38659 -24.53729 1.000 16.07065  ?  329 ALA A O    1 
ATOM   3968 C CB   . ALA A 1 248 ? 31.40113  -16.22714 -26.01072 1.000 18.51738  ?  329 ALA A CB   1 
ATOM   3969 H H    A ALA A 1 248 ? 31.50786  -13.79581 -26.52605 0.720 17.29981  ?  329 ALA A H    1 
ATOM   3970 D D    B ALA A 1 248 ? 31.50729  -13.79877 -26.52597 0.280 17.29981  ?  329 ALA A D    1 
ATOM   3971 H HA   . ALA A 1 248 ? 32.20239  -15.31967 -24.29021 1.000 18.21983  ?  329 ALA A HA   1 
ATOM   3972 H HB1  . ALA A 1 248 ? 31.37490  -17.16622 -25.45796 1.000 22.22085  ?  329 ALA A HB1  1 
ATOM   3973 H HB2  . ALA A 1 248 ? 30.41981  -15.75336 -25.98537 1.000 22.22085  ?  329 ALA A HB2  1 
ATOM   3974 H HB3  . ALA A 1 248 ? 31.69823  -16.41168 -27.04309 1.000 22.22085  ?  329 ALA A HB3  1 
ATOM   3975 N N    . PRO A 1 249 ? 34.56731  -15.54189 -26.60029 1.000 16.75443  ?  330 PRO A N    1 
ATOM   3976 C CA   . PRO A 1 249 ? 35.95749  -16.03083 -26.67946 1.000 16.31622  ?  330 PRO A CA   1 
ATOM   3977 C C    . PRO A 1 249 ? 36.86991  -15.41776 -25.65181 1.000 20.28094  ?  330 PRO A C    1 
ATOM   3978 O O    . PRO A 1 249 ? 37.83643  -16.06256 -25.20650 1.000 20.87948  ?  330 PRO A O    1 
ATOM   3979 C CB   . PRO A 1 249 ? 36.40113  -15.65934 -28.09790 1.000 22.64878  ?  330 PRO A CB   1 
ATOM   3980 C CG   . PRO A 1 249 ? 35.14095  -15.50906 -28.88045 1.000 24.53571  ?  330 PRO A CG   1 
ATOM   3981 C CD   . PRO A 1 249 ? 34.05746  -15.06230 -27.89264 1.000 18.71036  ?  330 PRO A CD   1 
ATOM   3982 H HA   . PRO A 1 249 ? 35.95928  -17.11582 -26.57507 1.000 19.57947  ?  330 PRO A HA   1 
ATOM   3983 H HB2  . PRO A 1 249 ? 36.95923  -14.72330 -28.07685 1.000 27.17854  ?  330 PRO A HB2  1 
ATOM   3984 H HB3  . PRO A 1 249 ? 37.02212  -16.45444 -28.51057 1.000 27.17854  ?  330 PRO A HB3  1 
ATOM   3985 H HG2  . PRO A 1 249 ? 35.28305  -14.75789 -29.65740 1.000 29.44286  ?  330 PRO A HG2  1 
ATOM   3986 H HG3  . PRO A 1 249 ? 34.87656  -16.46582 -29.33080 1.000 29.44286  ?  330 PRO A HG3  1 
ATOM   3987 H HD2  . PRO A 1 249 ? 33.95553  -13.97708 -27.89191 1.000 22.45243  ?  330 PRO A HD2  1 
ATOM   3988 H HD3  . PRO A 1 249 ? 33.10010  -15.52651 -28.12943 1.000 22.45243  ?  330 PRO A HD3  1 
ATOM   3989 N N    . LEU A 1 250 ? 36.59901  -14.17543 -25.23887 1.000 16.37466  ?  331 LEU A N    1 
ATOM   3990 C CA   . LEU A 1 250 ? 37.43041  -13.54978 -24.23896 1.000 17.47223  ?  331 LEU A CA   1 
ATOM   3991 C C    . LEU A 1 250 ? 37.28704  -14.23381 -22.89951 1.000 18.62796  ?  331 LEU A C    1 
ATOM   3992 O O    . LEU A 1 250 ? 38.25665  -14.37249 -22.15134 1.000 21.47497  ?  331 LEU A O    1 
ATOM   3993 C CB   . LEU A 1 250 ? 37.08751  -12.05733 -24.15750 1.000 19.25142  ?  331 LEU A CB   1 
ATOM   3994 C CG   . LEU A 1 250 ? 37.23088  -11.24802 -25.44365 1.000 22.19922  ?  331 LEU A CG   1 
ATOM   3995 C CD1  . LEU A 1 250 ? 36.83494  -9.80431  -25.17987 1.000 22.76153  ?  331 LEU A CD1  1 
ATOM   3996 C CD2  . LEU A 1 250 ? 38.67826  -11.31759 -25.94655 1.000 29.91567  ?  331 LEU A CD2  1 
ATOM   3997 H H    A LEU A 1 250 ? 35.82733  -13.60013 -25.57644 0.810 19.64959  ?  331 LEU A H    1 
ATOM   3998 D D    B LEU A 1 250 ? 35.82807  -13.59821 -25.57485 0.190 19.64959  ?  331 LEU A D    1 
ATOM   3999 H HA   . LEU A 1 250 ? 38.47990  -13.62762 -24.52291 1.000 20.96667  ?  331 LEU A HA   1 
ATOM   4000 H HB2  . LEU A 1 250 ? 36.04920  -11.96763 -23.83818 1.000 23.10171  ?  331 LEU A HB2  1 
ATOM   4001 H HB3  . LEU A 1 250 ? 37.74566  -11.60078 -23.41824 1.000 23.10171  ?  331 LEU A HB3  1 
ATOM   4002 H HG   . LEU A 1 250 ? 36.57904  -11.65664 -26.21582 1.000 26.63906  ?  331 LEU A HG   1 
ATOM   4003 H HD11 . LEU A 1 250 ? 35.82811  -9.63690  -25.56244 1.000 27.31384  ?  331 LEU A HD11 1 
ATOM   4004 H HD12 . LEU A 1 250 ? 36.85988  -9.62007  -24.10584 1.000 27.31384  ?  331 LEU A HD12 1 
ATOM   4005 H HD13 . LEU A 1 250 ? 37.53953  -9.14486  -25.68659 1.000 27.31384  ?  331 LEU A HD13 1 
ATOM   4006 H HD21 . LEU A 1 250 ? 38.93639  -12.35839 -26.14201 1.000 35.89881  ?  331 LEU A HD21 1 
ATOM   4007 H HD22 . LEU A 1 250 ? 38.76365  -10.73489 -26.86376 1.000 35.89881  ?  331 LEU A HD22 1 
ATOM   4008 H HD23 . LEU A 1 250 ? 39.33935  -10.90778 -25.18293 1.000 35.89881  ?  331 LEU A HD23 1 
ATOM   4009 N N    . LEU A 1 251 ? 36.08113  -14.70141 -22.58668 1.000 15.87781  ?  332 LEU A N    1 
ATOM   4010 C CA   . LEU A 1 251 ? 35.87989  -15.43135 -21.34535 1.000 16.33067  ?  332 LEU A CA   1 
ATOM   4011 C C    . LEU A 1 251 ? 36.52197  -16.81051 -21.41851 1.000 14.33113  ?  332 LEU A C    1 
ATOM   4012 O O    . LEU A 1 251 ? 37.14651  -17.26436 -20.44826 1.000 16.48556  ?  332 LEU A O    1 
ATOM   4013 C CB   . LEU A 1 251 ? 34.37973  -15.51488 -21.07993 1.000 14.96805  ?  332 LEU A CB   1 
ATOM   4014 C CG   . LEU A 1 251 ? 33.66328  -14.16592 -20.97085 1.000 15.20796  ?  332 LEU A CG   1 
ATOM   4015 C CD1  . LEU A 1 251 ? 32.15869  -14.40429 -20.83604 1.000 20.81249  ?  332 LEU A CD1  1 
ATOM   4016 C CD2  . LEU A 1 251 ? 34.19821  -13.40342 -19.78238 1.000 17.74943  ?  332 LEU A CD2  1 
ATOM   4017 H H    A LEU A 1 251 ? 35.24407  -14.59297 -23.15937 0.990 19.05337  ?  332 LEU A H    1 
ATOM   4018 D D    B LEU A 1 251 ? 35.24267  -14.59430 -23.15757 0.010 19.05337  ?  332 LEU A D    1 
ATOM   4019 H HA   . LEU A 1 251 ? 36.34647  -14.91044 -20.50926 1.000 19.59681  ?  332 LEU A HA   1 
ATOM   4020 H HB2  . LEU A 1 251 ? 33.91607  -16.06626 -21.89792 1.000 17.96166  ?  332 LEU A HB2  1 
ATOM   4021 H HB3  . LEU A 1 251 ? 34.22595  -16.04389 -20.13940 1.000 17.96166  ?  332 LEU A HB3  1 
ATOM   4022 H HG   . LEU A 1 251 ? 33.83767  -13.56504 -21.86339 1.000 18.24955  ?  332 LEU A HG   1 
ATOM   4023 H HD11 . LEU A 1 251 ? 31.64098  -13.44693 -20.89559 1.000 24.97499  ?  332 LEU A HD11 1 
ATOM   4024 H HD12 . LEU A 1 251 ? 31.82879  -15.05619 -21.64492 1.000 24.97499  ?  332 LEU A HD12 1 
ATOM   4025 H HD13 . LEU A 1 251 ? 31.95888  -14.87568 -19.87377 1.000 24.97499  ?  332 LEU A HD13 1 
ATOM   4026 H HD21 . LEU A 1 251 ? 34.07877  -12.33517 -19.96312 1.000 21.29931  ?  332 LEU A HD21 1 
ATOM   4027 H HD22 . LEU A 1 251 ? 33.63930  -13.69471 -18.89306 1.000 21.29931  ?  332 LEU A HD22 1 
ATOM   4028 H HD23 . LEU A 1 251 ? 35.25370  -13.64279 -19.65301 1.000 21.29931  ?  332 LEU A HD23 1 
ATOM   4029 N N    . GLN A 1 252 ? 36.36087  -17.48756 -22.55776 1.000 16.11787  ?  333 GLN A N    1 
ATOM   4030 C CA   . GLN A 1 252 ? 36.98976  -18.79706 -22.72624 1.000 17.81914  ?  333 GLN A CA   1 
ATOM   4031 C C    . GLN A 1 252 ? 38.49669  -18.71331 -22.56094 1.000 20.74972  ?  333 GLN A C    1 
ATOM   4032 O O    . GLN A 1 252 ? 39.09074  -19.58953 -21.93364 1.000 21.64381  ?  333 GLN A O    1 
ATOM   4033 C CB   . GLN A 1 252 ? 36.66355  -19.36481 -24.09680 1.000 19.54126  ?  333 GLN A CB   1 
ATOM   4034 C CG   . GLN A 1 252 ? 35.24882  -19.85000 -24.22146 1.000 22.20976  ?  333 GLN A CG   1 
ATOM   4035 C CD   . GLN A 1 252 ? 34.85275  -20.20411 -25.65221 1.000 30.55544  ?  333 GLN A CD   1 
ATOM   4036 O OE1  . GLN A 1 252 ? 35.48467  -19.75107 -26.62317 1.000 34.95448  ?  333 GLN A OE1  1 
ATOM   4037 N NE2  . GLN A 1 252 ? 33.79593  -21.00327 -25.78880 1.000 32.42502  ?  333 GLN A NE2  1 
ATOM   4038 H H    A GLN A 1 252 ? 35.81736  -17.16665 -23.35901 0.870 19.34144  ?  333 GLN A H    1 
ATOM   4039 D D    B GLN A 1 252 ? 35.81797  -17.16889 -23.36032 0.130 19.34144  ?  333 GLN A D    1 
ATOM   4040 H HA   . GLN A 1 252 ? 36.58952  -19.46621 -21.96457 1.000 21.38296  ?  333 GLN A HA   1 
ATOM   4041 H HB2  . GLN A 1 252 ? 36.81736  -18.58736 -24.84515 1.000 23.44951  ?  333 GLN A HB2  1 
ATOM   4042 H HB3  . GLN A 1 252 ? 37.32480  -20.20849 -24.29439 1.000 23.44951  ?  333 GLN A HB3  1 
ATOM   4043 H HG2  . GLN A 1 252 ? 35.12801  -20.74454 -23.61048 1.000 26.65172  ?  333 GLN A HG2  1 
ATOM   4044 H HG3  . GLN A 1 252 ? 34.57571  -19.06673 -23.87285 1.000 26.65172  ?  333 GLN A HG3  1 
ATOM   4045 N N    . GLN A 1 253 ? 39.12809  -17.67568 -23.10864 1.000 21.23219  ?  334 GLN A N    1 
ATOM   4046 C CA   A GLN A 1 253 ? 40.58659  -17.55128 -22.99577 0.590 23.28338  ?  334 GLN A CA   1 
ATOM   4047 C CA   B GLN A 1 253 ? 40.58408  -17.50346 -22.99036 0.410 23.47843  ?  334 GLN A CA   1 
ATOM   4048 C C    . GLN A 1 253 ? 41.02930  -17.55426 -21.54511 1.000 28.17880  ?  334 GLN A C    1 
ATOM   4049 O O    . GLN A 1 253 ? 42.13001  -18.02552 -21.24062 1.000 32.68657  ?  334 GLN A O    1 
ATOM   4050 C CB   A GLN A 1 253 ? 41.06786  -16.26779 -23.68803 0.590 29.07967  ?  334 GLN A CB   1 
ATOM   4051 C CB   B GLN A 1 253 ? 40.99824  -16.15149 -23.61845 0.410 29.80900  ?  334 GLN A CB   1 
ATOM   4052 C CG   A GLN A 1 253 ? 41.73778  -16.45048 -25.04842 0.590 45.34481  ?  334 GLN A CG   1 
ATOM   4053 C CG   B GLN A 1 253 ? 41.64699  -15.11916 -22.64942 0.410 39.25998  ?  334 GLN A CG   1 
ATOM   4054 C CD   A GLN A 1 253 ? 42.10833  -15.11878 -25.72355 0.590 53.07579  ?  334 GLN A CD   1 
ATOM   4055 C CD   B GLN A 1 253 ? 41.42136  -13.64267 -23.05980 0.410 39.65629  ?  334 GLN A CD   1 
ATOM   4056 O OE1  A GLN A 1 253 ? 41.27860  -14.51215 -26.40933 0.590 52.38066  ?  334 GLN A OE1  1 
ATOM   4057 O OE1  B GLN A 1 253 ? 40.67699  -12.90238 -22.39554 0.410 27.21798  ?  334 GLN A OE1  1 
ATOM   4058 N NE2  A GLN A 1 253 ? 43.35961  -14.67221 -25.54282 0.590 34.91774  ?  334 GLN A NE2  1 
ATOM   4059 N NE2  B GLN A 1 253 ? 42.07142  -13.21735 -24.14796 0.410 37.77799  ?  334 GLN A NE2  1 
ATOM   4060 H H    A GLN A 1 253 ? 38.67508  -16.92135 -23.62454 0.000 25.47863  ?  334 GLN A H    1 
ATOM   4061 D D    B GLN A 1 253 ? 38.67038  -16.93514 -23.64014 1.000 25.47863  ?  334 GLN A D    1 
ATOM   4062 H HA   A GLN A 1 253 ? 41.04851  -18.39971 -23.50064 0.590 27.94005  ?  334 GLN A HA   1 
ATOM   4063 H HA   B GLN A 1 253 ? 41.08458  -18.30596 -23.53221 0.410 28.17412  ?  334 GLN A HA   1 
ATOM   4064 H HB2  A GLN A 1 253 ? 40.20546  -15.61842 -23.83866 0.590 34.89561  ?  334 GLN A HB2  1 
ATOM   4065 H HB2  B GLN A 1 253 ? 41.72217  -16.35054 -24.40864 0.410 35.77080  ?  334 GLN A HB2  1 
ATOM   4066 H HB3  A GLN A 1 253 ? 41.79220  -15.78024 -23.03555 0.590 34.89561  ?  334 GLN A HB3  1 
ATOM   4067 H HB3  B GLN A 1 253 ? 40.10757  -15.68375 -24.03802 0.410 35.77080  ?  334 GLN A HB3  1 
ATOM   4068 H HG2  A GLN A 1 253 ? 42.65408  -17.02596 -24.91684 0.590 54.41377  ?  334 GLN A HG2  1 
ATOM   4069 H HG2  B GLN A 1 253 ? 41.22018  -15.25570 -21.65579 0.410 47.11198  ?  334 GLN A HG2  1 
ATOM   4070 H HG3  A GLN A 1 253 ? 41.05479  -16.98314 -25.71015 0.590 54.41377  ?  334 GLN A HG3  1 
ATOM   4071 H HG3  B GLN A 1 253 ? 42.72245  -15.29425 -22.62047 0.410 47.11198  ?  334 GLN A HG3  1 
ATOM   4072 N N    . ALA A 1 254 ? 40.19285  -17.05563 -20.64226 1.000 27.84071  ?  335 ALA A N    1 
ATOM   4073 C CA   . ALA A 1 254 ? 40.51294  -16.94440 -19.22164 1.000 21.32550  ?  335 ALA A CA   1 
ATOM   4074 C C    . ALA A 1 254 ? 40.17738  -18.18979 -18.43517 1.000 26.81456  ?  335 ALA A C    1 
ATOM   4075 O O    . ALA A 1 254 ? 40.36286  -18.20680 -17.21605 1.000 37.02122  ?  335 ALA A O    1 
ATOM   4076 C CB   . ALA A 1 254 ? 39.76331  -15.75191 -18.63118 1.000 29.17816  ?  335 ALA A CB   1 
ATOM   4077 H H    A ALA A 1 254 ? 39.26007  -16.71048 -20.86853 0.090 33.40885  ?  335 ALA A H    1 
ATOM   4078 D D    B ALA A 1 254 ? 39.26027  -16.71077 -20.86978 0.910 33.40885  ?  335 ALA A D    1 
ATOM   4079 H HA   . ALA A 1 254 ? 41.58398  -16.77318 -19.11366 1.000 25.59059  ?  335 ALA A HA   1 
ATOM   4080 H HB1  . ALA A 1 254 ? 40.44892  -14.90888 -18.54542 1.000 35.01379  ?  335 ALA A HB1  1 
ATOM   4081 H HB2  . ALA A 1 254 ? 38.93497  -15.49180 -19.29020 1.000 35.01379  ?  335 ALA A HB2  1 
ATOM   4082 H HB3  . ALA A 1 254 ? 39.38351  -16.02380 -17.64633 1.000 35.01379  ?  335 ALA A HB3  1 
ATOM   4083 N N    . GLY A 1 255 ? 39.67659  -19.22379 -19.08920 1.000 20.83872  ?  336 GLY A N    1 
ATOM   4084 C CA   . GLY A 1 255 ? 39.38155  -20.48740 -18.45780 1.000 24.70595  ?  336 GLY A CA   1 
ATOM   4085 C C    . GLY A 1 255 ? 37.91781  -20.73453 -18.14231 1.000 20.52226  ?  336 GLY A C    1 
ATOM   4086 O O    . GLY A 1 255 ? 37.59342  -21.78538 -17.57646 1.000 25.40519  ?  336 GLY A O    1 
ATOM   4087 H H    A GLY A 1 255 ? 39.45986  -19.21195 -20.08584 0.890 25.00647  ?  336 GLY A H    1 
ATOM   4088 D D    B GLY A 1 255 ? 39.46019  -19.21096 -20.08590 0.110 25.00647  ?  336 GLY A D    1 
ATOM   4089 H HA2  . GLY A 1 255 ? 39.71657  -21.28945 -19.11550 1.000 29.64714  ?  336 GLY A HA2  1 
ATOM   4090 H HA3  . GLY A 1 255 ? 39.93444  -20.54313 -17.52009 1.000 29.64714  ?  336 GLY A HA3  1 
ATOM   4091 N N    . TRP A 1 256 ? 37.01881  -19.82306 -18.54403 1.000 20.53827  ?  337 TRP A N    1 
ATOM   4092 C CA   . TRP A 1 256 ? 35.60783  -19.89927 -18.19103 1.000 16.63844  ?  337 TRP A CA   1 
ATOM   4093 C C    . TRP A 1 256 ? 34.84365  -20.22030 -19.46718 1.000 14.70595  ?  337 TRP A C    1 
ATOM   4094 O O    . TRP A 1 256 ? 34.70152  -19.36589 -20.34338 1.000 18.47909  ?  337 TRP A O    1 
ATOM   4095 C CB   . TRP A 1 256 ? 35.16800  -18.56429 -17.59684 1.000 15.87430  ?  337 TRP A CB   1 
ATOM   4096 C CG   . TRP A 1 256 ? 33.77104  -18.56764 -17.06046 1.000 14.86251  ?  337 TRP A CG   1 
ATOM   4097 C CD1  . TRP A 1 256 ? 32.96529  -19.64900 -16.80655 1.000 15.45594  ?  337 TRP A CD1  1 
ATOM   4098 C CD2  . TRP A 1 256 ? 33.01268  -17.41869 -16.73390 1.000 13.93302  ?  337 TRP A CD2  1 
ATOM   4099 N NE1  . TRP A 1 256 ? 31.74925  -19.21472 -16.32855 1.000 16.59452  ?  337 TRP A NE1  1 
ATOM   4100 C CE2  . TRP A 1 256 ? 31.75136  -17.85844 -16.27280 1.000 15.61475  ?  337 TRP A CE2  1 
ATOM   4101 C CE3  . TRP A 1 256 ? 33.27267  -16.05302 -16.77047 1.000 20.54959  ?  337 TRP A CE3  1 
ATOM   4102 C CZ2  . TRP A 1 256 ? 30.75814  -16.97583 -15.85660 1.000 17.10634  ?  337 TRP A CZ2  1 
ATOM   4103 C CZ3  . TRP A 1 256 ? 32.25403  -15.17683 -16.33792 1.000 21.02140  ?  337 TRP A CZ3  1 
ATOM   4104 C CH2  . TRP A 1 256 ? 31.03483  -15.65471 -15.89782 1.000 20.06415  ?  337 TRP A CH2  1 
ATOM   4105 H H    A TRP A 1 256 ? 37.25077  -19.01484 -19.12143 0.760 24.64592  ?  337 TRP A H    1 
ATOM   4106 D D    B TRP A 1 256 ? 37.25326  -19.01559 -19.12147 0.240 24.64592  ?  337 TRP A D    1 
ATOM   4107 H HA   . TRP A 1 256 ? 35.41872  -20.69030 -17.46536 1.000 19.96613  ?  337 TRP A HA   1 
ATOM   4108 H HB2  . TRP A 1 256 ? 35.83781  -18.30969 -16.77547 1.000 19.04916  ?  337 TRP A HB2  1 
ATOM   4109 H HB3  . TRP A 1 256 ? 35.22315  -17.80110 -18.37311 1.000 19.04916  ?  337 TRP A HB3  1 
ATOM   4110 H HD1  . TRP A 1 256 ? 33.24233  -20.68178 -16.95830 1.000 18.54713  ?  337 TRP A HD1  1 
ATOM   4111 H HE1  A TRP A 1 256 ? 30.97082  -19.81632 -16.05924 0.090 19.91343  ?  337 TRP A HE1  1 
ATOM   4112 D DE1  B TRP A 1 256 ? 30.97082  -19.81632 -16.05924 0.910 19.91343  ?  337 TRP A DE1  1 
ATOM   4113 H HE3  . TRP A 1 256 ? 34.22274  -15.67525 -17.11839 1.000 24.65951  ?  337 TRP A HE3  1 
ATOM   4114 H HZ2  . TRP A 1 256 ? 29.79958  -17.33538 -15.51268 1.000 20.52761  ?  337 TRP A HZ2  1 
ATOM   4115 H HZ3  . TRP A 1 256 ? 32.43131  -14.11157 -16.35129 1.000 25.22568  ?  337 TRP A HZ3  1 
ATOM   4116 H HH2  . TRP A 1 256 ? 30.28081  -14.95104 -15.57732 1.000 24.07698  ?  337 TRP A HH2  1 
ATOM   4117 N N    . ASP A 1 257 ? 34.31987  -21.43317 -19.53110 1.000 19.08157  ?  338 ASP A N    1 
ATOM   4118 C CA   . ASP A 1 257 ? 33.48843  -21.86934 -20.64771 1.000 23.24787  ?  338 ASP A CA   1 
ATOM   4119 C C    . ASP A 1 257 ? 32.08342  -21.34873 -20.35663 1.000 17.89205  ?  338 ASP A C    1 
ATOM   4120 O O    . ASP A 1 257 ? 31.17731  -22.07584 -19.96340 1.000 23.50494  ?  338 ASP A O    1 
ATOM   4121 C CB   . ASP A 1 257 ? 33.50486  -23.39405 -20.71969 1.000 30.95638  ?  338 ASP A CB   1 
ATOM   4122 C CG   . ASP A 1 257 ? 32.86776  -23.93181 -21.98799 1.000 34.85564  ?  338 ASP A CG   1 
ATOM   4123 O OD1  . ASP A 1 257 ? 32.75053  -23.16317 -22.96552 1.000 44.09612  ?  338 ASP A OD1  1 
ATOM   4124 O OD2  . ASP A 1 257 ? 32.50178  -25.12770 -21.99742 1.000 52.44364  -1 338 ASP A OD2  1 
ATOM   4125 H H    A ASP A 1 257 ? 34.45278  -22.14923 -18.81696 0.000 22.89789  ?  338 ASP A H    1 
ATOM   4126 D D    B ASP A 1 257 ? 34.45337  -22.14856 -18.81640 1.000 22.89789  ?  338 ASP A D    1 
ATOM   4127 H HA   . ASP A 1 257 ? 33.84658  -21.46652 -21.59511 1.000 27.89744  ?  338 ASP A HA   1 
ATOM   4128 H HB2  . ASP A 1 257 ? 34.53826  -23.73943 -20.68970 1.000 37.14765  ?  338 ASP A HB2  1 
ATOM   4129 H HB3  . ASP A 1 257 ? 32.95290  -23.79522 -19.86969 1.000 37.14765  ?  338 ASP A HB3  1 
ATOM   4130 N N    . ALA A 1 258 ? 31.90144  -20.06751 -20.57035 1.000 14.59564  ?  339 ALA A N    1 
ATOM   4131 C CA   . ALA A 1 258 ? 30.66011  -19.40898 -20.21653 1.000 13.44304  ?  339 ALA A CA   1 
ATOM   4132 C C    . ALA A 1 258 ? 29.63199  -19.51526 -21.30878 1.000 12.55596  ?  339 ALA A C    1 
ATOM   4133 O O    . ALA A 1 258 ? 29.93619  -19.42678 -22.50047 1.000 15.77571  ?  339 ALA A O    1 
ATOM   4134 C CB   . ALA A 1 258 ? 30.94150  -17.93865 -19.95796 1.000 16.22435  ?  339 ALA A CB   1 
ATOM   4135 H H    A ALA A 1 258 ? 32.59654  -19.44987 -20.98961 0.370 17.51476  ?  339 ALA A H    1 
ATOM   4136 D D    B ALA A 1 258 ? 32.59697  -19.45040 -20.98967 0.630 17.51476  ?  339 ALA A D    1 
ATOM   4137 H HA   . ALA A 1 258 ? 30.24409  -19.88640 -19.32934 1.000 16.13164  ?  339 ALA A HA   1 
ATOM   4138 H HB1  . ALA A 1 258 ? 31.58143  -17.84884 -19.08016 1.000 19.46922  ?  339 ALA A HB1  1 
ATOM   4139 H HB2  . ALA A 1 258 ? 31.44263  -17.51485 -20.82822 1.000 19.46922  ?  339 ALA A HB2  1 
ATOM   4140 H HB3  . ALA A 1 258 ? 29.99762  -17.42190 -19.78428 1.000 19.46922  ?  339 ALA A HB3  1 
ATOM   4141 N N    . THR A 1 259 ? 28.37952  -19.63323 -20.90227 1.000 11.80644  ?  340 THR A N    1 
ATOM   4142 C CA   . THR A 1 259 ? 27.24722  -19.57663 -21.81834 1.000 11.16974  ?  340 THR A CA   1 
ATOM   4143 C C    . THR A 1 259 ? 26.32692  -18.42983 -21.41945 1.000 10.51695  ?  340 THR A C    1 
ATOM   4144 O O    . THR A 1 259 ? 26.53014  -17.76798 -20.38987 1.000 13.46272  ?  340 THR A O    1 
ATOM   4145 C CB   . THR A 1 259 ? 26.51757  -20.90641 -21.88504 1.000 10.64035  ?  340 THR A CB   1 
ATOM   4146 O OG1  . THR A 1 259 ? 26.19026  -21.30657 -20.56279 1.000 12.97759  ?  340 THR A OG1  1 
ATOM   4147 C CG2  . THR A 1 259 ? 27.37301  -21.95261 -22.58941 1.000 15.69830  ?  340 THR A CG2  1 
ATOM   4148 H H    A THR A 1 259 ? 28.10982  -19.77138 -19.92832 1.000 14.16773  ?  340 THR A H    1 
ATOM   4149 D D    B THR A 1 259 ? 28.11218  -19.77134 -19.92766 0.000 14.16773  ?  340 THR A D    1 
ATOM   4150 H HA   . THR A 1 259 ? 27.59841  -19.36923 -22.82915 1.000 13.40369  ?  340 THR A HA   1 
ATOM   4151 H HB   . THR A 1 259 ? 25.59797  -20.81792 -22.46349 1.000 12.76842  ?  340 THR A HB   1 
ATOM   4152 H HG1  A THR A 1 259 ? 25.21691  -21.34387 -20.45513 0.050 15.57310  ?  340 THR A HG1  1 
ATOM   4153 D DG1  B THR A 1 259 ? 25.23411  -21.51265 -20.50196 0.950 15.57310  ?  340 THR A DG1  1 
ATOM   4154 H HG21 . THR A 1 259 ? 28.37361  -21.96836 -22.15737 1.000 18.83796  ?  340 THR A HG21 1 
ATOM   4155 H HG22 . THR A 1 259 ? 26.92345  -22.93916 -22.47666 1.000 18.83796  ?  340 THR A HG22 1 
ATOM   4156 H HG23 . THR A 1 259 ? 27.44977  -21.71808 -23.65111 1.000 18.83796  ?  340 THR A HG23 1 
ATOM   4157 N N    . PHE A 1 260 ? 25.33661  -18.18725 -22.25487 1.000 10.86914  ?  341 PHE A N    1 
ATOM   4158 C CA   . PHE A 1 260 ? 24.54420  -16.96583 -22.17912 1.000 10.17064  ?  341 PHE A CA   1 
ATOM   4159 C C    . PHE A 1 260 ? 23.06226  -17.26687 -22.25803 1.000 10.94734  ?  341 PHE A C    1 
ATOM   4160 O O    . PHE A 1 260 ? 22.63816  -18.24752 -22.88234 1.000 11.89380  ?  341 PHE A O    1 
ATOM   4161 C CB   . PHE A 1 260 ? 24.89298  -16.03302 -23.35793 1.000 10.96750  ?  341 PHE A CB   1 
ATOM   4162 C CG   . PHE A 1 260 ? 26.26315  -15.43670 -23.28810 1.000 11.88172  ?  341 PHE A CG   1 
ATOM   4163 C CD1  . PHE A 1 260 ? 27.39059  -16.19581 -23.56881 1.000 14.28036  ?  341 PHE A CD1  1 
ATOM   4164 C CD2  . PHE A 1 260 ? 26.41495  -14.11342 -22.97620 1.000 12.86225  ?  341 PHE A CD2  1 
ATOM   4165 C CE1  . PHE A 1 260 ? 28.66789  -15.63311 -23.48465 1.000 15.34754  ?  341 PHE A CE1  1 
ATOM   4166 C CE2  . PHE A 1 260 ? 27.67821  -13.53508 -22.92199 1.000 14.65613  ?  341 PHE A CE2  1 
ATOM   4167 C CZ   . PHE A 1 260 ? 28.78165  -14.28434 -23.19993 1.000 16.46926  ?  341 PHE A CZ   1 
ATOM   4168 H H    A PHE A 1 260 ? 25.05164  -18.81884 -23.00339 0.880 13.04297  ?  341 PHE A H    1 
ATOM   4169 D D    B PHE A 1 260 ? 25.05242  -18.81954 -23.00310 0.120 13.04297  ?  341 PHE A D    1 
ATOM   4170 H HA   . PHE A 1 260 ? 24.74040  -16.48699 -21.21978 1.000 12.20477  ?  341 PHE A HA   1 
ATOM   4171 H HB2  . PHE A 1 260 ? 24.82857  -16.60398 -24.28419 1.000 13.16100  ?  341 PHE A HB2  1 
ATOM   4172 H HB3  . PHE A 1 260 ? 24.17639  -15.21187 -23.37556 1.000 13.16100  ?  341 PHE A HB3  1 
ATOM   4173 H HD1  . PHE A 1 260 ? 27.28029  -17.23132 -23.85507 1.000 17.13644  ?  341 PHE A HD1  1 
ATOM   4174 H HD2  . PHE A 1 260 ? 25.54297  -13.51063 -22.76955 1.000 15.43470  ?  341 PHE A HD2  1 
ATOM   4175 H HE1  . PHE A 1 260 ? 29.54812  -16.23958 -23.63889 1.000 18.41705  ?  341 PHE A HE1  1 
ATOM   4176 H HE2  . PHE A 1 260 ? 27.78466  -12.49281 -22.65979 1.000 17.58736  ?  341 PHE A HE2  1 
ATOM   4177 H HZ   . PHE A 1 260 ? 29.75659  -13.81970 -23.19792 1.000 19.76311  ?  341 PHE A HZ   1 
ATOM   4178 N N    . ILE A 1 261 ? 22.26561  -16.36440 -21.71301 1.000 9.42513   ?  342 ILE A N    1 
ATOM   4179 C CA   . ILE A 1 261 ? 20.82785  -16.29451 -21.95910 1.000 10.11955  ?  342 ILE A CA   1 
ATOM   4180 C C    . ILE A 1 261 ? 20.51520  -14.87275 -22.39674 1.000 9.82977   ?  342 ILE A C    1 
ATOM   4181 O O    . ILE A 1 261 ? 21.18954  -13.92552 -21.98165 1.000 11.33681  ?  342 ILE A O    1 
ATOM   4182 C CB   . ILE A 1 261 ? 19.94412  -16.74733 -20.78618 1.000 10.20937  ?  342 ILE A CB   1 
ATOM   4183 C CG1  . ILE A 1 261 ? 20.15095  -15.86767 -19.54852 1.000 11.65022  ?  342 ILE A CG1  1 
ATOM   4184 C CG2  . ILE A 1 261 ? 20.21800  -18.22125 -20.47460 1.000 12.01338  ?  342 ILE A CG2  1 
ATOM   4185 C CD1  . ILE A 1 261 ? 19.24064  -16.25499 -18.40435 1.000 13.07698  ?  342 ILE A CD1  1 
ATOM   4186 H H    A ILE A 1 261 ? 22.59294  -15.64047 -21.07335 1.000 11.31015  ?  342 ILE A H    1 
ATOM   4187 D D    B ILE A 1 261 ? 22.59466  -15.64112 -21.07350 0.000 11.31015  ?  342 ILE A D    1 
ATOM   4188 H HA   . ILE A 1 261 ? 20.58138  -16.98559 -22.76518 1.000 12.14345  ?  342 ILE A HA   1 
ATOM   4189 H HB   . ILE A 1 261 ? 18.90055  -16.63471 -21.08009 1.000 12.25124  ?  342 ILE A HB   1 
ATOM   4190 H HG12 . ILE A 1 261 ? 21.18210  -15.96712 -19.20949 1.000 13.98027  ?  342 ILE A HG12 1 
ATOM   4191 H HG13 . ILE A 1 261 ? 19.94304  -14.83024 -19.81044 1.000 13.98027  ?  342 ILE A HG13 1 
ATOM   4192 H HG21 . ILE A 1 261 ? 20.24145  -18.35698 -19.39334 1.000 14.41606  ?  342 ILE A HG21 1 
ATOM   4193 H HG22 . ILE A 1 261 ? 19.42404  -18.82915 -20.90839 1.000 14.41606  ?  342 ILE A HG22 1 
ATOM   4194 H HG23 . ILE A 1 261 ? 21.17896  -18.50242 -20.90543 1.000 14.41606  ?  342 ILE A HG23 1 
ATOM   4195 H HD11 . ILE A 1 261 ? 18.44499  -16.89539 -18.78504 1.000 15.69237  ?  342 ILE A HD11 1 
ATOM   4196 H HD12 . ILE A 1 261 ? 19.82206  -16.79075 -17.65401 1.000 15.69237  ?  342 ILE A HD12 1 
ATOM   4197 H HD13 . ILE A 1 261 ? 18.81415  -15.35144 -17.96868 1.000 15.69237  ?  342 ILE A HD13 1 
ATOM   4198 N N    . VAL A 1 262 ? 19.50349  -14.73006 -23.23673 1.000 9.41720   ?  343 VAL A N    1 
ATOM   4199 C CA   . VAL A 1 262 ? 19.17959  -13.45678 -23.86194 1.000 10.40333  ?  343 VAL A CA   1 
ATOM   4200 C C    . VAL A 1 262 ? 17.69298  -13.19427 -23.70777 1.000 8.98833   ?  343 VAL A C    1 
ATOM   4201 O O    . VAL A 1 262 ? 16.87064  -13.96863 -24.18056 1.000 10.40913  ?  343 VAL A O    1 
ATOM   4202 C CB   . VAL A 1 262 ? 19.58813  -13.41098 -25.34284 1.000 10.91366  ?  343 VAL A CB   1 
ATOM   4203 C CG1  . VAL A 1 262 ? 19.34420  -12.06727 -25.91876 1.000 13.18733  ?  343 VAL A CG1  1 
ATOM   4204 C CG2  . VAL A 1 262 ? 21.04159  -13.80768 -25.52410 1.000 14.28568  ?  343 VAL A CG2  1 
ATOM   4205 H H    A VAL A 1 262 ? 18.87954  -15.48973 -23.50874 1.000 11.30064  ?  343 VAL A H    1 
ATOM   4206 D D    B VAL A 1 262 ? 18.88074  -15.49121 -23.50736 0.000 11.30064  ?  343 VAL A D    1 
ATOM   4207 H HA   . VAL A 1 262 ? 19.71256  -12.66719 -23.33222 1.000 12.48400  ?  343 VAL A HA   1 
ATOM   4208 H HB   . VAL A 1 262 ? 18.97330  -14.13060 -25.88342 1.000 13.09639  ?  343 VAL A HB   1 
ATOM   4209 H HG11 . VAL A 1 262 ? 20.02883  -11.35452 -25.45902 1.000 15.82480  ?  343 VAL A HG11 1 
ATOM   4210 H HG12 . VAL A 1 262 ? 19.51510  -12.10593 -26.99458 1.000 15.82480  ?  343 VAL A HG12 1 
ATOM   4211 H HG13 . VAL A 1 262 ? 18.31347  -11.77621 -25.71635 1.000 15.82480  ?  343 VAL A HG13 1 
ATOM   4212 H HG21 . VAL A 1 262 ? 21.67722  -12.97948 -25.21078 1.000 17.14281  ?  343 VAL A HG21 1 
ATOM   4213 H HG22 . VAL A 1 262 ? 21.24836  -14.68658 -24.91346 1.000 17.14281  ?  343 VAL A HG22 1 
ATOM   4214 H HG23 . VAL A 1 262 ? 21.21889  -14.03529 -26.57522 1.000 17.14281  ?  343 VAL A HG23 1 
ATOM   4215 N N    . ASP A 1 263 ? 17.35450  -12.04782 -23.12514 1.000 9.89239   ?  344 ASP A N    1 
ATOM   4216 C CA   . ASP A 1 263 ? 15.96646  -11.58605 -23.05684 1.000 10.56976  ?  344 ASP A CA   1 
ATOM   4217 C C    . ASP A 1 263 ? 15.49482  -11.12968 -24.43057 1.000 10.85530  ?  344 ASP A C    1 
ATOM   4218 O O    . ASP A 1 263 ? 16.15551  -10.32058 -25.07354 1.000 11.87669  ?  344 ASP A O    1 
ATOM   4219 C CB   . ASP A 1 263 ? 15.87730  -10.40264 -22.08252 1.000 9.51773   ?  344 ASP A CB   1 
ATOM   4220 C CG   . ASP A 1 263 ? 14.47773  -10.11248 -21.54596 1.000 11.39092  ?  344 ASP A CG   1 
ATOM   4221 O OD1  . ASP A 1 263 ? 13.50187  -10.67868 -22.07000 1.000 11.36260  ?  344 ASP A OD1  1 
ATOM   4222 O OD2  . ASP A 1 263 ? 14.39127  -9.28625  -20.58884 1.000 11.29043  -1 344 ASP A OD2  1 
ATOM   4223 H H    A ASP A 1 263 ? 18.01899  -11.40965 -22.68745 1.000 11.87086  ?  344 ASP A H    1 
ATOM   4224 D D    B ASP A 1 263 ? 18.01791  -11.40875 -22.68711 0.000 11.87086  ?  344 ASP A D    1 
ATOM   4225 H HA   . ASP A 1 263 ? 15.32630  -12.39921 -22.71467 1.000 12.68371  ?  344 ASP A HA   1 
ATOM   4226 H HB2  . ASP A 1 263 ? 16.51829  -10.61134 -21.22597 1.000 11.42127  ?  344 ASP A HB2  1 
ATOM   4227 H HB3  . ASP A 1 263 ? 16.22219  -9.50537  -22.59639 1.000 11.42127  ?  344 ASP A HB3  1 
ATOM   4228 N N    . GLN A 1 264 ? 14.37203  -11.64664 -24.88161 1.000 10.22891  ?  345 GLN A N    1 
ATOM   4229 C CA   . GLN A 1 264 ? 13.72698  -11.19249 -26.10394 1.000 10.35435  ?  345 GLN A CA   1 
ATOM   4230 C C    . GLN A 1 264 ? 12.25850  -10.83168 -25.87104 1.000 12.24395  ?  345 GLN A C    1 
ATOM   4231 O O    . GLN A 1 264 ? 11.50372  -10.65593 -26.85941 1.000 13.00085  ?  345 GLN A O    1 
ATOM   4232 C CB   . GLN A 1 264 ? 13.85325  -12.23419 -27.23864 1.000 11.37179  ?  345 GLN A CB   1 
ATOM   4233 C CG   . GLN A 1 264 ? 15.27241  -12.41284 -27.78964 1.000 12.27509  ?  345 GLN A CG   1 
ATOM   4234 C CD   . GLN A 1 264 ? 15.70813  -11.22392 -28.61785 1.000 14.95548  ?  345 GLN A CD   1 
ATOM   4235 O OE1  . GLN A 1 264 ? 15.30450  -11.10583 -29.77226 1.000 15.70653  ?  345 GLN A OE1  1 
ATOM   4236 N NE2  . GLN A 1 264 ? 16.50341  -10.34245 -28.07356 1.000 13.37676  ?  345 GLN A NE2  1 
ATOM   4237 H H    A GLN A 1 264 ? 13.86749  -12.40060 -24.41537 1.000 12.27470  ?  345 GLN A H    1 
ATOM   4238 D D    B GLN A 1 264 ? 13.86807  -12.40062 -24.41477 0.000 12.27470  ?  345 GLN A D    1 
ATOM   4239 H HA   . GLN A 1 264 ? 14.24130  -10.29222 -26.44022 1.000 12.42522  ?  345 GLN A HA   1 
ATOM   4240 H HB2  . GLN A 1 264 ? 13.52454  -13.20151 -26.85870 1.000 13.64615  ?  345 GLN A HB2  1 
ATOM   4241 H HB3  . GLN A 1 264 ? 13.21646  -11.92297 -28.06673 1.000 13.64615  ?  345 GLN A HB3  1 
ATOM   4242 H HG2  . GLN A 1 264 ? 15.96904  -12.52385 -26.95869 1.000 14.73011  ?  345 GLN A HG2  1 
ATOM   4243 H HG3  . GLN A 1 264 ? 15.30295  -13.29960 -28.42274 1.000 14.73011  ?  345 GLN A HG3  1 
ATOM   4244 H HE21 A GLN A 1 264 ? 16.81682  -10.46420 -27.11057 0.010 16.05212  ?  345 GLN A HE21 1 
ATOM   4245 D DE21 B GLN A 1 264 ? 16.81682  -10.46420 -27.11057 0.990 16.05212  ?  345 GLN A DE21 1 
ATOM   4246 H HE22 A GLN A 1 264 ? 16.81111  -9.53228  -28.61146 0.000 16.05212  ?  345 GLN A HE22 1 
ATOM   4247 D DE22 B GLN A 1 264 ? 16.81111  -9.53228  -28.61146 1.000 16.05212  ?  345 GLN A DE22 1 
ATOM   4248 N N    . GLY A 1 265 ? 11.82455  -10.65436 -24.61523 1.000 11.02688  ?  346 GLY A N    1 
ATOM   4249 C CA   . GLY A 1 265 ? 10.40948  -10.42292 -24.34280 1.000 12.86419  ?  346 GLY A CA   1 
ATOM   4250 C C    . GLY A 1 265 ? 9.84076   -9.17477  -24.99342 1.000 13.20364  ?  346 GLY A C    1 
ATOM   4251 O O    . GLY A 1 265 ? 8.65926   -9.17094  -25.36201 1.000 16.24621  ?  346 GLY A O    1 
ATOM   4252 H H    A GLY A 1 265 ? 12.41819  -10.66585 -23.78586 1.000 13.23225  ?  346 GLY A H    1 
ATOM   4253 D D    B GLY A 1 265 ? 12.41581  -10.66535 -23.78416 0.000 13.23225  ?  346 GLY A D    1 
ATOM   4254 H HA2  . GLY A 1 265 ? 9.83760   -11.27774 -24.70380 1.000 15.43703  ?  346 GLY A HA2  1 
ATOM   4255 H HA3  . GLY A 1 265 ? 10.26923  -10.33145 -23.26574 1.000 15.43703  ?  346 GLY A HA3  1 
ATOM   4256 N N    . ARG A 1 266 ? 10.64222  -8.14755  -25.19801 1.000 11.23970  ?  347 ARG A N    1 
ATOM   4257 C CA   . ARG A 1 266 ? 10.14297  -6.91368  -25.81525 1.000 12.07611  ?  347 ARG A CA   1 
ATOM   4258 C C    . ARG A 1 266 ? 10.92518  -6.55450  -27.07275 1.000 13.27793  ?  347 ARG A C    1 
ATOM   4259 O O    . ARG A 1 266 ? 11.08389  -5.37041  -27.39894 1.000 13.90307  ?  347 ARG A O    1 
ATOM   4260 C CB   . ARG A 1 266 ? 10.11341  -5.75604  -24.81263 1.000 12.61434  ?  347 ARG A CB   1 
ATOM   4261 C CG   . ARG A 1 266 ? 9.12745   -6.02526  -23.66164 1.000 13.72623  ?  347 ARG A CG   1 
ATOM   4262 C CD   . ARG A 1 266 ? 8.95493   -4.78482  -22.75866 1.000 14.92555  ?  347 ARG A CD   1 
ATOM   4263 N NE   . ARG A 1 266 ? 10.17776  -4.35264  -22.08728 1.000 13.28912  ?  347 ARG A NE   1 
ATOM   4264 C CZ   . ARG A 1 266 ? 10.26991  -3.25587  -21.34243 1.000 14.23521  ?  347 ARG A CZ   1 
ATOM   4265 N NH1  . ARG A 1 266 ? 9.20441   -2.49381  -21.08705 1.000 15.24602  ?  347 ARG A NH1  1 
ATOM   4266 N NH2  . ARG A 1 266 ? 11.43415  -2.91053  -20.83044 1.000 12.85898  ?  347 ARG A NH2  1 
ATOM   4267 H H    A ARG A 1 266 ? 11.63233  -8.12951  -24.95359 0.630 13.48764  ?  347 ARG A H    1 
ATOM   4268 D D    B ARG A 1 266 ? 11.63219  -8.13133  -24.95290 0.370 13.48764  ?  347 ARG A D    1 
ATOM   4269 H HA   . ARG A 1 266 ? 9.11131   -7.08221  -26.12407 1.000 14.49133  ?  347 ARG A HA   1 
ATOM   4270 H HB2  . ARG A 1 266 ? 11.10830  -5.62339  -24.38754 1.000 15.13720  ?  347 ARG A HB2  1 
ATOM   4271 H HB3  . ARG A 1 266 ? 9.80220   -4.84535  -25.32438 1.000 15.13720  ?  347 ARG A HB3  1 
ATOM   4272 H HG2  . ARG A 1 266 ? 8.15305   -6.28556  -24.07501 1.000 16.47148  ?  347 ARG A HG2  1 
ATOM   4273 H HG3  . ARG A 1 266 ? 9.50347   -6.84464  -23.04900 1.000 16.47148  ?  347 ARG A HG3  1 
ATOM   4274 H HD2  . ARG A 1 266 ? 8.60479   -3.95403  -23.37127 1.000 17.91066  ?  347 ARG A HD2  1 
ATOM   4275 H HD3  . ARG A 1 266 ? 8.21993   -5.01497  -21.98736 1.000 17.91066  ?  347 ARG A HD3  1 
ATOM   4276 H HE   A ARG A 1 266 ? 11.01273  -4.92817  -22.19681 0.000 15.94694  ?  347 ARG A HE   1 
ATOM   4277 D DE   B ARG A 1 266 ? 11.01273  -4.92817  -22.19681 1.000 15.94694  ?  347 ARG A DE   1 
ATOM   4278 H HH11 A ARG A 1 266 ? 8.29253   -2.74839  -21.46663 0.000 18.29522  ?  347 ARG A HH11 1 
ATOM   4279 D DH11 B ARG A 1 266 ? 8.29253   -2.74839  -21.46663 1.000 18.29522  ?  347 ARG A DH11 1 
ATOM   4280 H HH12 A ARG A 1 266 ? 9.30197   -1.65682  -20.51231 0.000 18.29522  ?  347 ARG A HH12 1 
ATOM   4281 D DH12 B ARG A 1 266 ? 9.30197   -1.65682  -20.51231 0.500 18.29522  ?  347 ARG A DH12 1 
ATOM   4282 H HH21 A ARG A 1 266 ? 12.25903  -3.48406  -21.00656 0.000 15.43078  ?  347 ARG A HH21 1 
ATOM   4283 D DH21 B ARG A 1 266 ? 12.25903  -3.48406  -21.00656 1.000 15.43078  ?  347 ARG A DH21 1 
ATOM   4284 H HH22 A ARG A 1 266 ? 11.51034  -2.06971  -20.25806 0.000 15.43078  ?  347 ARG A HH22 1 
ATOM   4285 D DH22 B ARG A 1 266 ? 11.51034  -2.06971  -20.25806 1.000 15.43078  ?  347 ARG A DH22 1 
ATOM   4286 N N    . SER A 1 267 ? 11.40527  -7.56499  -27.78232 1.000 12.99073  ?  348 SER A N    1 
ATOM   4287 C CA   . SER A 1 267 ? 12.29247  -7.36899  -28.92612 1.000 13.79398  ?  348 SER A CA   1 
ATOM   4288 C C    . SER A 1 267 ? 11.62366  -7.59945  -30.27720 1.000 13.84975  ?  348 SER A C    1 
ATOM   4289 O O    . SER A 1 267 ? 12.32399  -7.63018  -31.29482 1.000 15.84761  ?  348 SER A O    1 
ATOM   4290 C CB   . SER A 1 267 ? 13.52166  -8.25375  -28.80944 1.000 13.75522  ?  348 SER A CB   1 
ATOM   4291 O OG   . SER A 1 267 ? 14.30184  -7.81782  -27.70142 1.000 14.47084  ?  348 SER A OG   1 
ATOM   4292 H H    A SER A 1 267 ? 11.19713  -8.54480  -27.58978 1.000 15.58887  ?  348 SER A H    1 
ATOM   4293 D D    B SER A 1 267 ? 11.19617  -8.54434  -27.58849 0.000 15.58887  ?  348 SER A D    1 
ATOM   4294 H HA   . SER A 1 267 ? 12.61388  -6.32776  -28.90112 1.000 16.55278  ?  348 SER A HA   1 
ATOM   4295 H HB2  . SER A 1 267 ? 13.21193  -9.28683  -28.65156 1.000 16.50626  ?  348 SER A HB2  1 
ATOM   4296 H HB3  . SER A 1 267 ? 14.11241  -8.17701  -29.72225 1.000 16.50626  ?  348 SER A HB3  1 
ATOM   4297 H HG   A SER A 1 267 ? 15.23773  -7.71102  -27.97180 0.000 17.36501  ?  348 SER A HG   1 
ATOM   4298 D DG   B SER A 1 267 ? 15.22264  -7.64326  -27.98785 1.000 17.36501  ?  348 SER A DG   1 
ATOM   4299 N N    . GLY A 1 268 ? 10.30991  -7.76037  -30.32413 1.000 13.63890  ?  349 GLY A N    1 
ATOM   4300 C CA   . GLY A 1 268 ? 9.68926   -8.14880  -31.58785 1.000 16.57581  ?  349 GLY A CA   1 
ATOM   4301 C C    . GLY A 1 268 ? 9.72870   -7.05700  -32.63781 1.000 17.39236  ?  349 GLY A C    1 
ATOM   4302 O O    . GLY A 1 268 ? 9.68382   -7.36106  -33.83737 1.000 20.98473  ?  349 GLY A O    1 
ATOM   4303 H H    A GLY A 1 268 ? 9.66905   -7.63589  -29.54041 1.000 16.36667  ?  349 GLY A H    1 
ATOM   4304 D D    B GLY A 1 268 ? 9.66696   -7.63654  -29.54203 0.000 16.36667  ?  349 GLY A D    1 
ATOM   4305 H HA2  . GLY A 1 268 ? 10.20785  -9.02093  -31.98605 1.000 19.89097  ?  349 GLY A HA2  1 
ATOM   4306 H HA3  . GLY A 1 268 ? 8.64602   -8.40801  -31.40739 1.000 19.89097  ?  349 GLY A HA3  1 
ATOM   4307 N N    . VAL A 1 269 ? 9.78272   -5.80474  -32.22217 1.000 16.21784  ?  350 VAL A N    1 
ATOM   4308 C CA   . VAL A 1 269 ? 9.74361   -4.65553  -33.12727 1.000 18.75087  ?  350 VAL A CA   1 
ATOM   4309 C C    . VAL A 1 269 ? 11.05263  -3.89471  -32.98116 1.000 16.46597  ?  350 VAL A C    1 
ATOM   4310 O O    . VAL A 1 269 ? 11.41113  -3.44593  -31.88757 1.000 17.22837  ?  350 VAL A O    1 
ATOM   4311 C CB   . VAL A 1 269 ? 8.52678   -3.74272  -32.86565 1.000 16.11045  ?  350 VAL A CB   1 
ATOM   4312 C CG1  . VAL A 1 269 ? 8.53352   -2.58214  -33.85748 1.000 20.77898  ?  350 VAL A CG1  1 
ATOM   4313 C CG2  . VAL A 1 269 ? 7.22521   -4.54386  -32.95352 1.000 20.28114  ?  350 VAL A CG2  1 
ATOM   4314 H H    A VAL A 1 269 ? 9.85580   -5.53989  -31.23987 0.940 19.46140  ?  350 VAL A H    1 
ATOM   4315 D D    B VAL A 1 269 ? 9.85579   -5.54242  -31.23919 0.060 19.46140  ?  350 VAL A D    1 
ATOM   4316 H HA   . VAL A 1 269 ? 9.67396   -5.01373  -34.15437 1.000 22.50104  ?  350 VAL A HA   1 
ATOM   4317 H HB   . VAL A 1 269 ? 8.58652   -3.33114  -31.85811 1.000 19.33254  ?  350 VAL A HB   1 
ATOM   4318 H HG11 . VAL A 1 269 ? 9.30840   -1.87235  -33.56790 1.000 24.93477  ?  350 VAL A HG11 1 
ATOM   4319 H HG12 . VAL A 1 269 ? 8.73843   -2.96946  -34.85553 1.000 24.93477  ?  350 VAL A HG12 1 
ATOM   4320 H HG13 . VAL A 1 269 ? 7.55843   -2.09530  -33.84067 1.000 24.93477  ?  350 VAL A HG13 1 
ATOM   4321 H HG21 . VAL A 1 269 ? 7.31559   -5.28134  -33.75105 1.000 24.33737  ?  350 VAL A HG21 1 
ATOM   4322 H HG22 . VAL A 1 269 ? 7.05224   -5.04540  -32.00134 1.000 24.33737  ?  350 VAL A HG22 1 
ATOM   4323 H HG23 . VAL A 1 269 ? 6.40267   -3.86198  -33.16927 1.000 24.33737  ?  350 VAL A HG23 1 
ATOM   4324 N N    . GLN A 1 270 ? 11.76379  -3.73024  -34.08874 1.000 17.79190  ?  351 GLN A N    1 
ATOM   4325 C CA   . GLN A 1 270 ? 13.01125  -2.99696  -34.09291 1.000 16.17536  ?  351 GLN A CA   1 
ATOM   4326 C C    . GLN A 1 270 ? 12.81804  -1.59745  -34.67649 1.000 18.63418  ?  351 GLN A C    1 
ATOM   4327 O O    . GLN A 1 270 ? 11.74467  -1.26251  -35.18079 1.000 20.88877  ?  351 GLN A O    1 
ATOM   4328 C CB   . GLN A 1 270 ? 14.04644  -3.78836  -34.89280 1.000 17.78095  ?  351 GLN A CB   1 
ATOM   4329 C CG   . GLN A 1 270 ? 14.34330  -5.15041  -34.22734 1.000 17.57276  ?  351 GLN A CG   1 
ATOM   4330 C CD   . GLN A 1 270 ? 15.00805  -4.94880  -32.86018 1.000 15.38570  ?  351 GLN A CD   1 
ATOM   4331 O OE1  . GLN A 1 270 ? 16.01688  -4.27127  -32.74724 1.000 16.82826  ?  351 GLN A OE1  1 
ATOM   4332 N NE2  . GLN A 1 270 ? 14.41615  -5.52474  -31.83594 1.000 15.11819  ?  351 GLN A NE2  1 
ATOM   4333 H H    A GLN A 1 270 ? 11.49513  -4.09779  -35.00150 0.260 21.35029  ?  351 GLN A H    1 
ATOM   4334 D D    B GLN A 1 270 ? 11.49366  -4.09849  -35.00078 0.740 21.35029  ?  351 GLN A D    1 
ATOM   4335 H HA   . GLN A 1 270 ? 13.37424  -2.86756  -33.07330 1.000 19.41043  ?  351 GLN A HA   1 
ATOM   4336 H HB2  . GLN A 1 270 ? 13.66467  -3.97099  -35.89729 1.000 21.33714  ?  351 GLN A HB2  1 
ATOM   4337 H HB3  . GLN A 1 270 ? 14.97505  -3.21992  -34.94454 1.000 21.33714  ?  351 GLN A HB3  1 
ATOM   4338 H HG2  . GLN A 1 270 ? 13.41110  -5.69660  -34.08317 1.000 21.08731  ?  351 GLN A HG2  1 
ATOM   4339 H HG3  . GLN A 1 270 ? 15.01856  -5.72601  -34.86043 1.000 21.08731  ?  351 GLN A HG3  1 
ATOM   4340 H HE21 A GLN A 1 270 ? 14.80897  -5.42833  -30.89957 0.150 18.14183  ?  351 GLN A HE21 1 
ATOM   4341 D DE21 B GLN A 1 270 ? 14.80897  -5.42833  -30.89957 0.850 18.14183  ?  351 GLN A DE21 1 
ATOM   4342 H HE22 A GLN A 1 270 ? 13.56445  -6.06766  -31.97829 0.270 18.14183  ?  351 GLN A HE22 1 
ATOM   4343 D DE22 B GLN A 1 270 ? 13.56445  -6.06766  -31.97829 0.730 18.14183  ?  351 GLN A DE22 1 
ATOM   4344 N N    . ASN A 1 271 ? 13.84983  -0.77522  -34.55822 1.000 16.64873  ?  352 ASN A N    1 
ATOM   4345 C CA   . ASN A 1 271 ? 13.86202  0.56597   -35.17460 1.000 19.20629  ?  352 ASN A CA   1 
ATOM   4346 C C    . ASN A 1 271 ? 12.74823  1.44533   -34.60504 1.000 27.20921  ?  352 ASN A C    1 
ATOM   4347 O O    . ASN A 1 271 ? 12.05563  2.15635   -35.34814 1.000 24.73198  ?  352 ASN A O    1 
ATOM   4348 C CB   . ASN A 1 271 ? 13.72656  0.48426   -36.70621 1.000 21.27558  ?  352 ASN A CB   1 
ATOM   4349 C CG   . ASN A 1 271 ? 14.86613  -0.27697  -37.37624 1.000 26.52460  ?  352 ASN A CG   1 
ATOM   4350 O OD1  . ASN A 1 271 ? 15.75625  -0.80047  -36.71238 1.000 22.39275  ?  352 ASN A OD1  1 
ATOM   4351 N ND2  . ASN A 1 271 ? 14.83281  -0.35719  -38.71630 1.000 28.63791  ?  352 ASN A ND2  1 
ATOM   4352 H H    A ASN A 1 271 ? 14.70123  -0.99787  -34.04252 0.120 19.97848  ?  352 ASN A H    1 
ATOM   4353 D D    B ASN A 1 271 ? 14.70089  -0.99869  -34.04231 0.880 19.97848  ?  352 ASN A D    1 
ATOM   4354 H HA   . ASN A 1 271 ? 14.81974  1.02979   -34.93849 1.000 23.04755  ?  352 ASN A HA   1 
ATOM   4355 H HB2  . ASN A 1 271 ? 12.79500  -0.02612  -36.95075 1.000 25.53070  ?  352 ASN A HB2  1 
ATOM   4356 H HB3  . ASN A 1 271 ? 13.71570  1.49531   -37.11335 1.000 25.53070  ?  352 ASN A HB3  1 
ATOM   4357 N N    . ILE A 1 272 ? 12.55711  1.39728   -33.28264 1.000 21.69603  ?  353 ILE A N    1 
ATOM   4358 C CA   . ILE A 1 272 ? 11.54763  2.19624   -32.59211 1.000 19.71583  ?  353 ILE A CA   1 
ATOM   4359 C C    . ILE A 1 272 ? 12.14441  3.17304   -31.59653 1.000 19.91865  ?  353 ILE A C    1 
ATOM   4360 O O    . ILE A 1 272 ? 11.39976  3.90026   -30.94993 1.000 25.77580  ?  353 ILE A O    1 
ATOM   4361 C CB   . ILE A 1 272 ? 10.47145  1.32139   -31.91029 1.000 20.43159  ?  353 ILE A CB   1 
ATOM   4362 C CG1  . ILE A 1 272 ? 11.14984  0.23503   -31.04778 1.000 20.90383  ?  353 ILE A CG1  1 
ATOM   4363 C CG2  . ILE A 1 272 ? 9.48150   0.79317   -32.94039 1.000 24.70635  ?  353 ILE A CG2  1 
ATOM   4364 C CD1  . ILE A 1 272 ? 10.23706  -0.48162  -30.19515 1.000 23.12193  ?  353 ILE A CD1  1 
ATOM   4365 H H    A ILE A 1 272 ? 13.09798  0.80236   -32.65500 0.070 26.03523  ?  353 ILE A H    1 
ATOM   4366 D D    B ILE A 1 272 ? 13.09898  0.80170   -32.65649 0.930 26.03523  ?  353 ILE A D    1 
ATOM   4367 H HA   . ILE A 1 272 ? 11.03563  2.79038   -33.34905 1.000 23.65900  ?  353 ILE A HA   1 
ATOM   4368 H HB   . ILE A 1 272 ? 9.87569   1.92053   -31.22168 1.000 24.51790  ?  353 ILE A HB   1 
ATOM   4369 H HG12 . ILE A 1 272 ? 11.62708  -0.48932  -31.70783 1.000 25.08460  ?  353 ILE A HG12 1 
ATOM   4370 H HG13 . ILE A 1 272 ? 11.89739  0.70871   -30.41147 1.000 25.08460  ?  353 ILE A HG13 1 
ATOM   4371 H HG21 . ILE A 1 272 ? 8.58322   1.41018   -32.91826 1.000 29.64762  ?  353 ILE A HG21 1 
ATOM   4372 H HG22 . ILE A 1 272 ? 9.93940   0.83862   -33.92850 1.000 29.64762  ?  353 ILE A HG22 1 
ATOM   4373 H HG23 . ILE A 1 272 ? 9.22997   -0.23849  -32.69438 1.000 29.64762  ?  353 ILE A HG23 1 
ATOM   4374 H HD11 . ILE A 1 272 ? 9.81252   0.21084   -29.46827 1.000 27.74631  ?  353 ILE A HD11 1 
ATOM   4375 H HD12 . ILE A 1 272 ? 9.44358   -0.91143  -30.80651 1.000 27.74631  ?  353 ILE A HD12 1 
ATOM   4376 H HD13 . ILE A 1 272 ? 10.78027  -1.27408  -29.68034 1.000 27.74631  ?  353 ILE A HD13 1 
ATOM   4377 N N    . ARG A 1 273 ? 13.45147  3.23300   -31.44391 1.000 20.78431  ?  354 ARG A N    1 
ATOM   4378 C CA   . ARG A 1 273 ? 14.08961  4.14232   -30.50809 1.000 19.65473  ?  354 ARG A CA   1 
ATOM   4379 C C    . ARG A 1 273 ? 14.76050  5.29021   -31.25009 1.000 22.48529  ?  354 ARG A C    1 
ATOM   4380 O O    . ARG A 1 273 ? 15.26512  5.12201   -32.36400 1.000 24.18449  ?  354 ARG A O    1 
ATOM   4381 C CB   . ARG A 1 273 ? 15.11811  3.43245   -29.60324 1.000 20.04326  ?  354 ARG A CB   1 
ATOM   4382 C CG   . ARG A 1 273 ? 14.51106  2.57008   -28.51634 1.000 17.82610  ?  354 ARG A CG   1 
ATOM   4383 C CD   . ARG A 1 273 ? 15.55238  1.74457   -27.81438 1.000 18.82307  ?  354 ARG A CD   1 
ATOM   4384 N NE   . ARG A 1 273 ? 16.02095  0.64125   -28.62733 1.000 16.46740  ?  354 ARG A NE   1 
ATOM   4385 C CZ   . ARG A 1 273 ? 16.83765  -0.31683  -28.18034 1.000 19.81304  ?  354 ARG A CZ   1 
ATOM   4386 N NH1  . ARG A 1 273 ? 17.31490  -0.29066  -26.95388 1.000 21.79070  ?  354 ARG A NH1  1 
ATOM   4387 N NH2  . ARG A 1 273 ? 17.17043  -1.31836  -28.98287 1.000 16.61196  ?  354 ARG A NH2  1 
ATOM   4388 H H    A ARG A 1 273 ? 14.11079  2.65364   -31.96355 0.220 24.94117  ?  354 ARG A H    1 
ATOM   4389 D D    B ARG A 1 273 ? 14.10914  2.65270   -31.96459 0.780 24.94117  ?  354 ARG A D    1 
ATOM   4390 H HA   . ARG A 1 273 ? 13.31865  4.55708   -29.85872 1.000 23.58567  ?  354 ARG A HA   1 
ATOM   4391 H HB2  . ARG A 1 273 ? 15.74073  2.78870   -30.22455 1.000 24.05191  ?  354 ARG A HB2  1 
ATOM   4392 H HB3  . ARG A 1 273 ? 15.73337  4.18960   -29.11716 1.000 24.05191  ?  354 ARG A HB3  1 
ATOM   4393 H HG2  . ARG A 1 273 ? 14.02711  3.20922   -27.77784 1.000 21.39132  ?  354 ARG A HG2  1 
ATOM   4394 H HG3  . ARG A 1 273 ? 13.78056  1.89333   -28.95960 1.000 21.39132  ?  354 ARG A HG3  1 
ATOM   4395 H HD2  . ARG A 1 273 ? 16.40777  2.37652   -27.57554 1.000 22.58768  ?  354 ARG A HD2  1 
ATOM   4396 H HD3  . ARG A 1 273 ? 15.12537  1.33377   -26.89949 1.000 22.58768  ?  354 ARG A HD3  1 
ATOM   4397 H HE   A ARG A 1 273 ? 15.70931  0.59296   -29.59735 0.000 19.76088  ?  354 ARG A HE   1 
ATOM   4398 D DE   B ARG A 1 273 ? 15.70931  0.59296   -29.59735 1.000 19.76088  ?  354 ARG A DE   1 
ATOM   4399 H HH11 A ARG A 1 273 ? 17.93711  -1.03239  -26.63281 0.000 26.14884  ?  354 ARG A HH11 1 
ATOM   4400 D DH11 B ARG A 1 273 ? 17.93711  -1.03239  -26.63281 1.000 26.14884  ?  354 ARG A DH11 1 
ATOM   4401 H HH12 A ARG A 1 273 ? 17.06251  0.47136   -26.32457 0.000 26.14884  ?  354 ARG A HH12 1 
ATOM   4402 D DH12 B ARG A 1 273 ? 17.06251  0.47136   -26.32457 1.000 26.14884  ?  354 ARG A DH12 1 
ATOM   4403 H HH21 A ARG A 1 273 ? 16.80340  -1.35340  -29.93390 0.020 19.93435  ?  354 ARG A HH21 1 
ATOM   4404 D DH21 B ARG A 1 273 ? 16.80340  -1.35340  -29.93390 0.980 19.93435  ?  354 ARG A DH21 1 
ATOM   4405 H HH22 A ARG A 1 273 ? 17.79348  -2.05383  -28.64924 0.000 19.93435  ?  354 ARG A HH22 1 
ATOM   4406 D DH22 B ARG A 1 273 ? 17.79348  -2.05383  -28.64924 1.000 19.93435  ?  354 ARG A DH22 1 
ATOM   4407 N N    . GLN A 1 274 ? 14.75956  6.46183   -30.61168 1.000 22.18901  ?  355 GLN A N    1 
ATOM   4408 C CA   A GLN A 1 274 ? 15.45337  7.62059   -31.17182 0.560 23.89441  ?  355 GLN A CA   1 
ATOM   4409 C CA   B GLN A 1 274 ? 15.45561  7.60117   -31.19279 0.440 23.92003  ?  355 GLN A CA   1 
ATOM   4410 C C    . GLN A 1 274 ? 16.93702  7.58052   -30.84798 1.000 25.10000  ?  355 GLN A C    1 
ATOM   4411 O O    . GLN A 1 274 ? 17.77183  7.99569   -31.66816 1.000 30.27223  ?  355 GLN A O    1 
ATOM   4412 C CB   A GLN A 1 274 ? 14.84659  8.93809   -30.66759 0.560 27.53619  ?  355 GLN A CB   1 
ATOM   4413 C CB   B GLN A 1 274 ? 14.76978  8.90124   -30.76521 0.440 27.63417  ?  355 GLN A CB   1 
ATOM   4414 C CG   A GLN A 1 274 ? 15.81354  10.13974  -30.78329 0.560 32.48062  ?  355 GLN A CG   1 
ATOM   4415 C CG   B GLN A 1 274 ? 13.43899  9.07589   -31.46923 0.440 28.31634  ?  355 GLN A CG   1 
ATOM   4416 C CD   A GLN A 1 274 ? 15.12001  11.49955  -30.63134 0.560 40.16144  ?  355 GLN A CD   1 
ATOM   4417 C CD   B GLN A 1 274 ? 12.52162  10.06958  -30.80071 0.440 36.90619  ?  355 GLN A CD   1 
ATOM   4418 O OE1  A GLN A 1 274 ? 15.27628  12.18912  -29.62352 0.560 30.70369  ?  355 GLN A OE1  1 
ATOM   4419 O OE1  B GLN A 1 274 ? 11.48537  10.43233  -31.35800 0.440 38.61247  ?  355 GLN A OE1  1 
ATOM   4420 N NE2  A GLN A 1 274 ? 14.36392  11.88597  -31.64720 0.560 38.24878  ?  355 GLN A NE2  1 
ATOM   4421 N NE2  B GLN A 1 274 ? 12.88642  10.51065  -29.59236 0.440 36.79042  ?  355 GLN A NE2  1 
ATOM   4422 H H    A GLN A 1 274 ? 14.29583  6.63824   -29.72048 0.070 26.62682  ?  355 GLN A H    1 
ATOM   4423 D D    B GLN A 1 274 ? 14.30057  6.64662   -29.71973 0.930 26.62682  ?  355 GLN A D    1 
ATOM   4424 H HA   A GLN A 1 274 ? 15.32176  7.59709   -32.25359 0.560 28.67329  ?  355 GLN A HA   1 
ATOM   4425 H HA   B GLN A 1 274 ? 15.39060  7.56979   -32.28039 0.440 28.70403  ?  355 GLN A HA   1 
ATOM   4426 H HB2  A GLN A 1 274 ? 13.95794  9.16509   -31.25654 0.560 33.04343  ?  355 GLN A HB2  1 
ATOM   4427 H HB2  B GLN A 1 274 ? 14.59101  8.87899   -29.69020 0.440 33.16100  ?  355 GLN A HB2  1 
ATOM   4428 H HB3  A GLN A 1 274 ? 14.57853  8.82354   -29.61730 0.560 33.04343  ?  355 GLN A HB3  1 
ATOM   4429 H HB3  B GLN A 1 274 ? 15.40822  9.74729   -31.01953 0.440 33.16100  ?  355 GLN A HB3  1 
ATOM   4430 H HG2  A GLN A 1 274 ? 16.56819  10.06094  -30.00073 0.560 38.97675  ?  355 GLN A HG2  1 
ATOM   4431 H HG2  B GLN A 1 274 ? 13.62305  9.42538   -32.48515 0.440 33.97960  ?  355 GLN A HG2  1 
ATOM   4432 H HG3  A GLN A 1 274 ? 16.28924  10.11567  -31.76371 0.560 38.97675  ?  355 GLN A HG3  1 
ATOM   4433 H HG3  B GLN A 1 274 ? 12.92608  8.11440   -31.49293 0.440 33.97960  ?  355 GLN A HG3  1 
ATOM   4434 N N    . GLN A 1 275 ? 17.29416  7.08774   -29.66404 1.000 24.93580  ?  356 GLN A N    1 
ATOM   4435 C CA   A GLN A 1 275 ? 18.69048  6.85898   -29.33786 0.410 21.20116  ?  356 GLN A CA   1 
ATOM   4436 C CA   B GLN A 1 275 ? 18.67573  6.91642   -29.23196 0.590 21.21105  ?  356 GLN A CA   1 
ATOM   4437 C C    . GLN A 1 275 ? 18.79201  5.54296   -28.57668 1.000 22.96778  ?  356 GLN A C    1 
ATOM   4438 O O    . GLN A 1 275 ? 17.82030  5.06026   -27.98479 1.000 21.05399  ?  356 GLN A O    1 
ATOM   4439 C CB   A GLN A 1 275 ? 19.32574  8.04479   -28.58858 0.410 25.24720  ?  356 GLN A CB   1 
ATOM   4440 C CB   B GLN A 1 275 ? 19.10760  7.97782   -28.20447 0.590 25.12213  ?  356 GLN A CB   1 
ATOM   4441 C CG   A GLN A 1 275 ? 19.26216  9.39725   -29.37705 0.410 29.69880  ?  356 GLN A CG   1 
ATOM   4442 C CG   B GLN A 1 275 ? 19.71387  9.25152   -28.81340 0.590 36.70508  ?  356 GLN A CG   1 
ATOM   4443 C CD   A GLN A 1 275 ? 20.51848  9.72883   -30.22380 0.410 22.47933  ?  356 GLN A CD   1 
ATOM   4444 C CD   B GLN A 1 275 ? 20.40961  10.14154  -27.78342 0.590 29.50277  ?  356 GLN A CD   1 
ATOM   4445 O OE1  A GLN A 1 275 ? 21.56070  10.13131  -29.68948 0.410 29.68577  ?  356 GLN A OE1  1 
ATOM   4446 O OE1  B GLN A 1 275 ? 21.56084  10.56852  -27.95979 0.590 26.22340  ?  356 GLN A OE1  1 
ATOM   4447 N NE2  A GLN A 1 275 ? 20.40472  9.58305   -31.54129 0.410 25.96706  ?  356 GLN A NE2  1 
ATOM   4448 N NE2  B GLN A 1 275 ? 19.69480  10.43872  -26.70976 0.590 37.97814  ?  356 GLN A NE2  1 
ATOM   4449 H H    A GLN A 1 275 ? 16.64124  6.84101   -28.92025 0.000 29.92296  ?  356 GLN A H    1 
ATOM   4450 D D    B GLN A 1 275 ? 16.62196  6.78781   -28.95793 1.000 29.92296  ?  356 GLN A D    1 
ATOM   4451 H HA   A GLN A 1 275 ? 19.28199  6.74947   -30.24682 0.410 25.44139  ?  356 GLN A HA   1 
ATOM   4452 H HA   B GLN A 1 275 ? 19.33570  6.98937   -30.09638 0.590 25.45326  ?  356 GLN A HA   1 
ATOM   4453 H HB2  A GLN A 1 275 ? 18.79942  8.18505   -27.64443 0.410 30.29664  ?  356 GLN A HB2  1 
ATOM   4454 H HB2  B GLN A 1 275 ? 18.23334  8.27491   -27.62523 0.590 30.14656  ?  356 GLN A HB2  1 
ATOM   4455 H HB3  A GLN A 1 275 ? 20.37523  7.81847   -28.40031 0.410 30.29664  ?  356 GLN A HB3  1 
ATOM   4456 H HB3  B GLN A 1 275 ? 19.85835  7.53854   -27.54757 0.590 30.14656  ?  356 GLN A HB3  1 
ATOM   4457 H HG2  A GLN A 1 275 ? 18.41190  9.35928   -30.05802 0.410 35.63857  ?  356 GLN A HG2  1 
ATOM   4458 H HG2  B GLN A 1 275 ? 20.45224  8.96737   -29.56317 0.590 44.04610  ?  356 GLN A HG2  1 
ATOM   4459 H HG3  A GLN A 1 275 ? 19.12992  10.20782  -28.66041 0.410 35.63857  ?  356 GLN A HG3  1 
ATOM   4460 H HG3  B GLN A 1 275 ? 18.91792  9.83483   -29.27634 0.590 44.04610  ?  356 GLN A HG3  1 
ATOM   4461 N N    . TRP A 1 276 ? 19.97986  4.93793   -28.63712 1.000 17.35693  ?  357 TRP A N    1 
ATOM   4462 C CA   . TRP A 1 276 ? 20.15329  3.58804   -28.07880 1.000 18.22395  ?  357 TRP A CA   1 
ATOM   4463 C C    . TRP A 1 276 ? 19.95507  3.57708   -26.57290 1.000 19.23473  ?  357 TRP A C    1 
ATOM   4464 O O    . TRP A 1 276 ? 19.52966  2.56080   -26.02093 1.000 19.49327  ?  357 TRP A O    1 
ATOM   4465 C CB   . TRP A 1 276 ? 21.54022  3.02794   -28.41448 1.000 15.87774  ?  357 TRP A CB   1 
ATOM   4466 C CG   . TRP A 1 276 ? 21.56442  1.52502   -28.58539 1.000 14.52408  ?  357 TRP A CG   1 
ATOM   4467 C CD1  . TRP A 1 276 ? 20.59557  0.61210   -28.21138 1.000 15.24492  ?  357 TRP A CD1  1 
ATOM   4468 C CD2  . TRP A 1 276 ? 22.60883  0.78044   -29.19724 1.000 14.79031  ?  357 TRP A CD2  1 
ATOM   4469 N NE1  . TRP A 1 276 ? 20.99259  -0.67117  -28.57325 1.000 15.55365  ?  357 TRP A NE1  1 
ATOM   4470 C CE2  . TRP A 1 276 ? 22.23044  -0.58848  -29.16567 1.000 14.00841  ?  357 TRP A CE2  1 
ATOM   4471 C CE3  . TRP A 1 276 ? 23.83771  1.13424   -29.78760 1.000 16.04095  ?  357 TRP A CE3  1 
ATOM   4472 C CZ2  . TRP A 1 276 ? 23.01550  -1.58187  -29.71999 1.000 13.50376  ?  357 TRP A CZ2  1 
ATOM   4473 C CZ3  . TRP A 1 276 ? 24.63355  0.12698   -30.30771 1.000 15.37197  ?  357 TRP A CZ3  1 
ATOM   4474 C CH2  . TRP A 1 276 ? 24.21712  -1.20334  -30.26405 1.000 14.59976  ?  357 TRP A CH2  1 
ATOM   4475 H H    A TRP A 1 276 ? 20.82059  5.33901   -29.05272 0.000 20.82831  ?  357 TRP A H    1 
ATOM   4476 D D    B TRP A 1 276 ? 20.82195  5.33679   -29.05210 1.000 20.82831  ?  357 TRP A D    1 
ATOM   4477 H HA   . TRP A 1 276 ? 19.40812  2.93909   -28.53889 1.000 21.86874  ?  357 TRP A HA   1 
ATOM   4478 H HB2  . TRP A 1 276 ? 21.88228  3.47461   -29.34806 1.000 19.05329  ?  357 TRP A HB2  1 
ATOM   4479 H HB3  . TRP A 1 276 ? 22.22608  3.28207   -27.60633 1.000 19.05329  ?  357 TRP A HB3  1 
ATOM   4480 H HD1  . TRP A 1 276 ? 19.66957  0.85834   -27.71310 1.000 18.29391  ?  357 TRP A HD1  1 
ATOM   4481 H HE3  . TRP A 1 276 ? 24.15201  2.16647   -29.83363 1.000 19.24914  ?  357 TRP A HE3  1 
ATOM   4482 H HZ2  . TRP A 1 276 ? 22.69635  -2.61362  -29.72474 1.000 16.20452  ?  357 TRP A HZ2  1 
ATOM   4483 H HZ3  . TRP A 1 276 ? 25.58649  0.37433   -30.75170 1.000 18.44636  ?  357 TRP A HZ3  1 
ATOM   4484 H HH2  . TRP A 1 276 ? 24.86473  -1.96429  -30.67387 1.000 17.51971  ?  357 TRP A HH2  1 
ATOM   4485 N N    . GLY A 1 277 ? 20.27529  4.67640   -25.88976 1.000 18.88987  ?  358 GLY A N    1 
ATOM   4486 C CA   . GLY A 1 277 ? 20.16695  4.73794   -24.43498 1.000 20.05714  ?  358 GLY A CA   1 
ATOM   4487 C C    . GLY A 1 277 ? 18.74061  4.81888   -23.90990 1.000 17.97233  ?  358 GLY A C    1 
ATOM   4488 O O    . GLY A 1 277 ? 18.54571  4.66111   -22.70030 1.000 24.07181  ?  358 GLY A O    1 
ATOM   4489 H H    A GLY A 1 277 ? 20.61256  5.53982   -26.31538 0.310 22.66785  ?  358 GLY A H    1 
ATOM   4490 D D    B GLY A 1 277 ? 20.61262  5.54023   -26.31450 0.690 22.66785  ?  358 GLY A D    1 
ATOM   4491 H HA2  . GLY A 1 277 ? 20.62855  3.84614   -24.01106 1.000 24.06856  ?  358 GLY A HA2  1 
ATOM   4492 H HA3  . GLY A 1 277 ? 20.70355  5.61797   -24.08043 1.000 24.06856  ?  358 GLY A HA3  1 
ATOM   4493 N N    . ASP A 1 278 ? 17.76072  5.00613   -24.76678 1.000 17.52796  ?  359 ASP A N    1 
ATOM   4494 C CA   . ASP A 1 278 ? 16.37200  5.17394   -24.32748 1.000 18.05316  ?  359 ASP A CA   1 
ATOM   4495 C C    . ASP A 1 278 ? 15.81399  3.81037   -23.93611 1.000 18.82480  ?  359 ASP A C    1 
ATOM   4496 O O    . ASP A 1 278 ? 15.75030  2.88365   -24.77282 1.000 19.51029  ?  359 ASP A O    1 
ATOM   4497 C CB   . ASP A 1 278 ? 15.50956  5.75180   -25.43562 1.000 20.44307  ?  359 ASP A CB   1 
ATOM   4498 C CG   . ASP A 1 278 ? 15.98364  7.11504   -25.91670 1.000 23.26313  ?  359 ASP A CG   1 
ATOM   4499 O OD1  . ASP A 1 278 ? 16.80513  7.74387   -25.23454 1.000 24.61229  ?  359 ASP A OD1  1 
ATOM   4500 O OD2  . ASP A 1 278 ? 15.50021  7.52301   -26.99490 1.000 23.46277  -1 359 ASP A OD2  1 
ATOM   4501 H H    A ASP A 1 278 ? 17.88292  5.04877   -25.77854 0.090 21.03355  ?  359 ASP A H    1 
ATOM   4502 D D    B ASP A 1 278 ? 17.88296  5.04876   -25.77853 0.910 21.03355  ?  359 ASP A D    1 
ATOM   4503 H HA   . ASP A 1 278 ? 16.35528  5.85612   -23.47751 1.000 21.66379  ?  359 ASP A HA   1 
ATOM   4504 H HB2  . ASP A 1 278 ? 15.52667  5.07179   -26.28732 1.000 24.53168  ?  359 ASP A HB2  1 
ATOM   4505 H HB3  . ASP A 1 278 ? 14.48958  5.86286   -25.06767 1.000 24.53168  ?  359 ASP A HB3  1 
ATOM   4506 N N    . TRP A 1 279 ? 15.39460  3.68241   -22.68971 1.000 17.25843  ?  360 TRP A N    1 
ATOM   4507 C CA   . TRP A 1 279 ? 15.03639  2.37771   -22.14195 1.000 17.60574  ?  360 TRP A CA   1 
ATOM   4508 C C    . TRP A 1 279 ? 13.62719  2.31266   -21.58151 1.000 15.95460  ?  360 TRP A C    1 
ATOM   4509 O O    . TRP A 1 279 ? 13.16183  1.21843   -21.28109 1.000 15.79260  ?  360 TRP A O    1 
ATOM   4510 C CB   . TRP A 1 279 ? 16.05412  1.94678   -21.05535 1.000 17.85633  ?  360 TRP A CB   1 
ATOM   4511 C CG   . TRP A 1 279 ? 16.17766  2.97845   -19.98169 1.000 21.61151  ?  360 TRP A CG   1 
ATOM   4512 C CD1  . TRP A 1 279 ? 17.08457  3.99851   -19.91881 1.000 22.66597  ?  360 TRP A CD1  1 
ATOM   4513 C CD2  . TRP A 1 279 ? 15.34143  3.11425   -18.82036 1.000 21.63982  ?  360 TRP A CD2  1 
ATOM   4514 N NE1  . TRP A 1 279 ? 16.87104  4.76164   -18.77603 1.000 28.39059  ?  360 TRP A NE1  1 
ATOM   4515 C CE2  . TRP A 1 279 ? 15.80585  4.24052   -18.09413 1.000 29.12505  ?  360 TRP A CE2  1 
ATOM   4516 C CE3  . TRP A 1 279 ? 14.24800  2.39216   -18.32042 1.000 20.90927  ?  360 TRP A CE3  1 
ATOM   4517 C CZ2  . TRP A 1 279 ? 15.21321  4.66269   -16.89370 1.000 32.50894  ?  360 TRP A CZ2  1 
ATOM   4518 C CZ3  . TRP A 1 279 ? 13.65590  2.82487   -17.11684 1.000 22.47142  ?  360 TRP A CZ3  1 
ATOM   4519 C CH2  . TRP A 1 279 ? 14.14509  3.94334   -16.42707 1.000 23.81652  ?  360 TRP A CH2  1 
ATOM   4520 H H    A TRP A 1 279 ? 15.29092  4.45627   -22.03337 0.260 20.71012  ?  360 TRP A H    1 
ATOM   4521 D D    B TRP A 1 279 ? 15.29109  4.45660   -22.03373 0.740 20.71012  ?  360 TRP A D    1 
ATOM   4522 H HA   . TRP A 1 279 ? 15.09386  1.63567   -22.93830 1.000 21.12689  ?  360 TRP A HA   1 
ATOM   4523 H HB2  . TRP A 1 279 ? 15.72117  1.01450   -20.59917 1.000 21.42759  ?  360 TRP A HB2  1 
ATOM   4524 H HB3  . TRP A 1 279 ? 17.03354  1.80874   -21.51337 1.000 21.42759  ?  360 TRP A HB3  1 
ATOM   4525 H HD1  . TRP A 1 279 ? 17.85609  4.18523   -20.65112 1.000 27.19916  ?  360 TRP A HD1  1 
ATOM   4526 H HE1  A TRP A 1 279 ? 17.41789  5.57490   -18.49325 0.160 34.06870  ?  360 TRP A HE1  1 
ATOM   4527 D DE1  B TRP A 1 279 ? 17.41789  5.57490   -18.49325 0.840 34.06870  ?  360 TRP A DE1  1 
ATOM   4528 H HE3  . TRP A 1 279 ? 13.86946  1.52685   -18.84421 1.000 25.09113  ?  360 TRP A HE3  1 
ATOM   4529 H HZ2  . TRP A 1 279 ? 15.58577  5.52311   -16.35773 1.000 39.01073  ?  360 TRP A HZ2  1 
ATOM   4530 H HZ3  . TRP A 1 279 ? 12.80966  2.28491   -16.71844 1.000 26.96571  ?  360 TRP A HZ3  1 
ATOM   4531 H HH2  . TRP A 1 279 ? 13.66839  4.24476   -15.50604 1.000 28.57982  ?  360 TRP A HH2  1 
ATOM   4532 N N    . CYS A 1 280 ? 12.92919  3.43379   -21.43340 1.000 17.05193  ?  361 CYS A N    1 
ATOM   4533 C CA   . CYS A 1 280 ? 11.72361  3.45234   -20.60914 1.000 16.81292  ?  361 CYS A CA   1 
ATOM   4534 C C    . CYS A 1 280 ? 10.45036  3.35700   -21.44558 1.000 16.02569  ?  361 CYS A C    1 
ATOM   4535 O O    . CYS A 1 280 ? 10.11521  4.27133   -22.20087 1.000 18.51592  ?  361 CYS A O    1 
ATOM   4536 C CB   . CYS A 1 280 ? 11.71689  4.68405   -19.70642 1.000 16.61206  ?  361 CYS A CB   1 
ATOM   4537 S SG   . CYS A 1 280 ? 10.33129  4.65694   -18.54853 1.000 18.40348  ?  361 CYS A SG   1 
ATOM   4538 H H    A CYS A 1 280 ? 13.16860  4.32737   -21.86304 0.000 20.46232  ?  361 CYS A H    1 
ATOM   4539 D D    B CYS A 1 280 ? 13.17022  4.32652   -21.86390 1.000 20.46232  ?  361 CYS A D    1 
ATOM   4540 H HA   . CYS A 1 280 ? 11.73243  2.54972   -19.99817 1.000 20.17551  ?  361 CYS A HA   1 
ATOM   4541 H HB2  . CYS A 1 280 ? 12.64277  4.71322   -19.13197 1.000 19.93447  ?  361 CYS A HB2  1 
ATOM   4542 H HB3  . CYS A 1 280 ? 11.63156  5.57970   -20.32175 1.000 19.93447  ?  361 CYS A HB3  1 
ATOM   4543 N N    . ASN A 1 281 ? 9.70101   2.26246   -21.26185 1.000 13.37360  ?  362 ASN A N    1 
ATOM   4544 C CA   . ASN A 1 281 ? 8.38737   2.05057   -21.89598 1.000 14.03888  ?  362 ASN A CA   1 
ATOM   4545 C C    . ASN A 1 281 ? 8.39410   2.41988   -23.37557 1.000 17.17040  ?  362 ASN A C    1 
ATOM   4546 O O    . ASN A 1 281 ? 7.55680   3.18144   -23.85597 1.000 15.39739  ?  362 ASN A O    1 
ATOM   4547 C CB   . ASN A 1 281 ? 7.26425   2.83274   -21.19707 1.000 15.28218  ?  362 ASN A CB   1 
ATOM   4548 C CG   . ASN A 1 281 ? 7.21464   2.59723   -19.72454 1.000 15.47480  ?  362 ASN A CG   1 
ATOM   4549 O OD1  . ASN A 1 281 ? 7.22650   1.45686   -19.25166 1.000 16.01073  ?  362 ASN A OD1  1 
ATOM   4550 N ND2  . ASN A 1 281 ? 7.16091   3.67861   -18.96934 1.000 16.14314  ?  362 ASN A ND2  1 
ATOM   4551 H H    A ASN A 1 281 ? 9.98126   1.48409   -20.66519 0.790 16.04832  ?  362 ASN A H    1 
ATOM   4552 D D    B ASN A 1 281 ? 9.98234   1.48470   -20.66491 0.210 16.04832  ?  362 ASN A D    1 
ATOM   4553 H HA   . ASN A 1 281 ? 8.18697   0.98342   -21.80042 1.000 16.84666  ?  362 ASN A HA   1 
ATOM   4554 H HB2  . ASN A 1 281 ? 7.42091   3.89890   -21.36100 1.000 18.33861  ?  362 ASN A HB2  1 
ATOM   4555 H HB3  . ASN A 1 281 ? 6.30613   2.52769   -21.61785 1.000 18.33861  ?  362 ASN A HB3  1 
ATOM   4556 N N    . ILE A 1 282 ? 9.33964   1.87101   -24.12939 1.000 15.63873  ?  363 ILE A N    1 
ATOM   4557 C CA   . ILE A 1 282 ? 9.52359   2.34954   -25.48950 1.000 15.93531  ?  363 ILE A CA   1 
ATOM   4558 C C    . ILE A 1 282 ? 8.27497   2.05073   -26.30805 1.000 16.80032  ?  363 ILE A C    1 
ATOM   4559 O O    . ILE A 1 282 ? 7.76905   0.92424   -26.35356 1.000 17.07813  ?  363 ILE A O    1 
ATOM   4560 C CB   . ILE A 1 282 ? 10.78533  1.74170   -26.11906 1.000 16.36273  ?  363 ILE A CB   1 
ATOM   4561 C CG1  . ILE A 1 282 ? 12.06158  2.19399   -25.41524 1.000 16.50319  ?  363 ILE A CG1  1 
ATOM   4562 C CG2  . ILE A 1 282 ? 10.87234  2.13997   -27.58261 1.000 20.88824  ?  363 ILE A CG2  1 
ATOM   4563 C CD1  . ILE A 1 282 ? 12.28557  3.69004   -25.34241 1.000 21.33388  ?  363 ILE A CD1  1 
ATOM   4564 H H    A ILE A 1 282 ? 9.96880   1.12309   -23.83755 1.000 18.76647  ?  363 ILE A H    1 
ATOM   4565 D D    B ILE A 1 282 ? 9.96937   1.12311   -23.83872 0.000 18.76647  ?  363 ILE A D    1 
ATOM   4566 H HA   . ILE A 1 282 ? 9.65767   3.43105   -25.46852 1.000 19.12237  ?  363 ILE A HA   1 
ATOM   4567 H HB   . ILE A 1 282 ? 10.70148  0.66021   -26.01215 1.000 19.63527  ?  363 ILE A HB   1 
ATOM   4568 H HG12 . ILE A 1 282 ? 12.03564  1.82228   -24.39090 1.000 19.80383  ?  363 ILE A HG12 1 
ATOM   4569 H HG13 . ILE A 1 282 ? 12.91266  1.76665   -25.94546 1.000 19.80383  ?  363 ILE A HG13 1 
ATOM   4570 H HG21 . ILE A 1 282 ? 11.39181  3.09508   -27.66021 1.000 25.06589  ?  363 ILE A HG21 1 
ATOM   4571 H HG22 . ILE A 1 282 ? 11.42228  1.37243   -28.12717 1.000 25.06589  ?  363 ILE A HG22 1 
ATOM   4572 H HG23 . ILE A 1 282 ? 9.86389   2.23149   -27.98604 1.000 25.06589  ?  363 ILE A HG23 1 
ATOM   4573 H HD11 . ILE A 1 282 ? 11.35629  4.20071   -25.59491 1.000 25.60065  ?  363 ILE A HD11 1 
ATOM   4574 H HD12 . ILE A 1 282 ? 12.59166  3.95418   -24.33017 1.000 25.60065  ?  363 ILE A HD12 1 
ATOM   4575 H HD13 . ILE A 1 282 ? 13.06622  3.96689   -26.05096 1.000 25.60065  ?  363 ILE A HD13 1 
ATOM   4576 N N    . LYS A 1 283 ? 7.77830   3.08527   -26.98105 1.000 18.32928  ?  364 LYS A N    1 
ATOM   4577 C CA   . LYS A 1 283 ? 6.48151   3.04647   -27.64690 1.000 21.15088  ?  364 LYS A CA   1 
ATOM   4578 C C    . LYS A 1 283 ? 6.54462   2.17055   -28.89030 1.000 15.82837  ?  364 LYS A C    1 
ATOM   4579 O O    . LYS A 1 283 ? 7.49510   2.26817   -29.68546 1.000 21.86701  ?  364 LYS A O    1 
ATOM   4580 C CB   . LYS A 1 283 ? 6.12158   4.50183   -28.01730 1.000 27.30573  ?  364 LYS A CB   1 
ATOM   4581 C CG   . LYS A 1 283 ? 4.78980   4.66210   -28.72515 1.000 40.40283  ?  364 LYS A CG   1 
ATOM   4582 C CD   . LYS A 1 283 ? 4.26025   6.08968   -28.68274 1.000 53.67620  ?  364 LYS A CD   1 
ATOM   4583 C CE   . LYS A 1 283 ? 5.11969   7.05840   -29.48686 1.000 65.89745  ?  364 LYS A CE   1 
ATOM   4584 N NZ   . LYS A 1 283 ? 4.63563   8.46907   -29.33110 1.000 66.62171  ?  364 LYS A NZ   1 
ATOM   4585 H H    A LYS A 1 283 ? 8.25752   3.97960   -27.08549 0.830 21.99513  ?  364 LYS A H    1 
ATOM   4586 D D    B LYS A 1 283 ? 8.25640   3.98011   -27.08628 0.170 21.99513  ?  364 LYS A D    1 
ATOM   4587 H HA   . LYS A 1 283 ? 5.71315   2.62042   -27.00176 1.000 25.38105  ?  364 LYS A HA   1 
ATOM   4588 H HB2  . LYS A 1 283 ? 6.08067   5.09253   -27.10215 1.000 32.76687  ?  364 LYS A HB2  1 
ATOM   4589 H HB3  . LYS A 1 283 ? 6.89468   4.89253   -28.67895 1.000 32.76687  ?  364 LYS A HB3  1 
ATOM   4590 H HG2  . LYS A 1 283 ? 4.90807   4.37933   -29.77117 1.000 48.48340  ?  364 LYS A HG2  1 
ATOM   4591 H HG3  . LYS A 1 283 ? 4.05360   4.01705   -28.24554 1.000 48.48340  ?  364 LYS A HG3  1 
ATOM   4592 H HD2  . LYS A 1 283 ? 3.25266   6.10829   -29.09810 1.000 64.41144  ?  364 LYS A HD2  1 
ATOM   4593 H HD3  . LYS A 1 283 ? 4.24345   6.43274   -27.64827 1.000 64.41144  ?  364 LYS A HD3  1 
ATOM   4594 H HE2  . LYS A 1 283 ? 6.14990   7.00695   -29.13454 1.000 79.07694  ?  364 LYS A HE2  1 
ATOM   4595 H HE3  . LYS A 1 283 ? 5.07321   6.79302   -30.54304 1.000 79.07694  ?  364 LYS A HE3  1 
ATOM   4596 N N    . GLY A 1 284 ? 5.55551   1.29965   -29.03115 1.000 17.76023  ?  365 GLY A N    1 
ATOM   4597 C CA   . GLY A 1 284 ? 5.45955   0.44963   -30.18416 1.000 18.75979  ?  365 GLY A CA   1 
ATOM   4598 C C    . GLY A 1 284 ? 6.12465   -0.90079  -30.04865 1.000 20.49425  ?  365 GLY A C    1 
ATOM   4599 O O    . GLY A 1 284 ? 6.12489   -1.67484  -31.01385 1.000 21.46798  ?  365 GLY A O    1 
ATOM   4600 H H    A GLY A 1 284 ? 4.80557   1.16700   -28.35263 0.080 21.31228  ?  365 GLY A H    1 
ATOM   4601 D D    B GLY A 1 284 ? 4.80583   1.16746   -28.35226 0.920 21.31228  ?  365 GLY A D    1 
ATOM   4602 H HA2  . GLY A 1 284 ? 4.40539   0.27818   -30.40201 1.000 22.51175  ?  365 GLY A HA2  1 
ATOM   4603 H HA3  . GLY A 1 284 ? 5.91840   0.96028   -31.03080 1.000 22.51175  ?  365 GLY A HA3  1 
ATOM   4604 N N    . ALA A 1 285 ? 6.68628   -1.21133  -28.88805 1.000 17.99961  ?  366 ALA A N    1 
ATOM   4605 C CA   . ALA A 1 285 ? 7.35314   -2.49662  -28.73287 1.000 16.58957  ?  366 ALA A CA   1 
ATOM   4606 C C    . ALA A 1 285 ? 6.36081   -3.64261  -28.87538 1.000 15.64295  ?  366 ALA A C    1 
ATOM   4607 O O    . ALA A 1 285 ? 5.18745   -3.52951  -28.50670 1.000 17.34020  ?  366 ALA A O    1 
ATOM   4608 C CB   . ALA A 1 285 ? 7.98186   -2.55170  -27.33475 1.000 17.31455  ?  366 ALA A CB   1 
ATOM   4609 H H    A ALA A 1 285 ? 6.69713   -0.61430  -28.06110 0.000 21.59953  ?  366 ALA A H    1 
ATOM   4610 D D    B ALA A 1 285 ? 6.69802   -0.61552  -28.06024 1.000 21.59953  ?  366 ALA A D    1 
ATOM   4611 H HA   . ALA A 1 285 ? 8.12103   -2.61465  -29.49741 1.000 19.90748  ?  366 ALA A HA   1 
ATOM   4612 H HB1  . ALA A 1 285 ? 7.21223   -2.81651  -26.60974 1.000 20.77745  ?  366 ALA A HB1  1 
ATOM   4613 H HB2  . ALA A 1 285 ? 8.77133   -3.30324  -27.33002 1.000 20.77745  ?  366 ALA A HB2  1 
ATOM   4614 H HB3  . ALA A 1 285 ? 8.39836   -1.57357  -27.09416 1.000 20.77745  ?  366 ALA A HB3  1 
ATOM   4615 N N    . GLY A 1 286 ? 6.86563   -4.78928  -29.34272 1.000 14.99269  ?  367 GLY A N    1 
ATOM   4616 C CA   . GLY A 1 286 ? 6.07726   -5.99769  -29.44269 1.000 15.03187  ?  367 GLY A CA   1 
ATOM   4617 C C    . GLY A 1 286 ? 6.76937   -7.15849  -28.74602 1.000 13.43374  ?  367 GLY A C    1 
ATOM   4618 O O    . GLY A 1 286 ? 7.99176   -7.19386  -28.63263 1.000 15.41215  ?  367 GLY A O    1 
ATOM   4619 H H    A GLY A 1 286 ? 7.82835   -4.90229  -29.66019 1.000 17.99123  ?  367 GLY A H    1 
ATOM   4620 D D    B GLY A 1 286 ? 7.82831   -4.90251  -29.66024 0.000 17.99123  ?  367 GLY A D    1 
ATOM   4621 H HA2  . GLY A 1 286 ? 5.10396   -5.84080  -28.97774 1.000 18.03824  ?  367 GLY A HA2  1 
ATOM   4622 H HA3  . GLY A 1 286 ? 5.93197   -6.25574  -30.49169 1.000 18.03824  ?  367 GLY A HA3  1 
ATOM   4623 N N    . PHE A 1 287 ? 5.97571   -8.12220  -28.32734 1.000 14.17907  ?  368 PHE A N    1 
ATOM   4624 C CA   . PHE A 1 287 ? 6.55102   -9.35274  -27.80006 1.000 14.68994  ?  368 PHE A CA   1 
ATOM   4625 C C    . PHE A 1 287 ? 7.43179   -9.96979  -28.87399 1.000 16.03541  ?  368 PHE A C    1 
ATOM   4626 O O    . PHE A 1 287 ? 7.07867   -9.98062  -30.05815 1.000 16.85092  ?  368 PHE A O    1 
ATOM   4627 C CB   . PHE A 1 287 ? 5.45618   -10.32814 -27.41498 1.000 15.98979  ?  368 PHE A CB   1 
ATOM   4628 C CG   . PHE A 1 287 ? 4.79164   -10.03232 -26.11726 1.000 14.80928  ?  368 PHE A CG   1 
ATOM   4629 C CD1  . PHE A 1 287 ? 5.51642   -9.86851  -24.97569 1.000 15.97640  ?  368 PHE A CD1  1 
ATOM   4630 C CD2  . PHE A 1 287 ? 3.40359   -9.96783  -26.01523 1.000 18.30619  ?  368 PHE A CD2  1 
ATOM   4631 C CE1  . PHE A 1 287 ? 4.88977   -9.62181  -23.77580 1.000 18.16559  ?  368 PHE A CE1  1 
ATOM   4632 C CE2  . PHE A 1 287 ? 2.80678   -9.72561  -24.81374 1.000 18.86751  ?  368 PHE A CE2  1 
ATOM   4633 C CZ   . PHE A 1 287 ? 3.51740   -9.57187  -23.71381 1.000 18.97104  ?  368 PHE A CZ   1 
ATOM   4634 H H    A PHE A 1 287 ? 4.95626   -8.09007  -28.33647 1.000 17.01488  ?  368 PHE A H    1 
ATOM   4635 D D    B PHE A 1 287 ? 4.95620   -8.09175  -28.33575 0.000 17.01488  ?  368 PHE A D    1 
ATOM   4636 H HA   . PHE A 1 287 ? 7.13857   -9.14498  -26.90578 1.000 17.62793  ?  368 PHE A HA   1 
ATOM   4637 H HB2  . PHE A 1 287 ? 4.68860   -10.31105 -28.18869 1.000 19.18775  ?  368 PHE A HB2  1 
ATOM   4638 H HB3  . PHE A 1 287 ? 5.89003   -11.32543 -27.34223 1.000 19.18775  ?  368 PHE A HB3  1 
ATOM   4639 H HD1  . PHE A 1 287 ? 6.59386   -9.93292  -25.01271 1.000 19.17168  ?  368 PHE A HD1  1 
ATOM   4640 H HD2  . PHE A 1 287 ? 2.79501   -10.11103 -26.89588 1.000 21.96743  ?  368 PHE A HD2  1 
ATOM   4641 H HE1  . PHE A 1 287 ? 5.47638   -9.46733  -22.88225 1.000 21.79871  ?  368 PHE A HE1  1 
ATOM   4642 H HE2  . PHE A 1 287 ? 1.73013   -9.65828  -24.76179 1.000 22.64102  ?  368 PHE A HE2  1 
ATOM   4643 H HZ   . PHE A 1 287 ? 3.02316   -9.40733  -22.76774 1.000 22.76525  ?  368 PHE A HZ   1 
ATOM   4644 N N    . GLY A 1 288 ? 8.59965   -10.47500 -28.47488 1.000 14.49661  ?  369 GLY A N    1 
ATOM   4645 C CA   . GLY A 1 288 ? 9.54832   -11.08739 -29.38462 1.000 14.63574  ?  369 GLY A CA   1 
ATOM   4646 C C    . GLY A 1 288 ? 9.51348   -12.60011 -29.36769 1.000 14.33221  ?  369 GLY A C    1 
ATOM   4647 O O    . GLY A 1 288 ? 8.54933   -13.22860 -28.93529 1.000 14.61362  ?  369 GLY A O    1 
ATOM   4648 H H    A GLY A 1 288 ? 8.91560   -10.47058 -27.50505 0.870 17.39593  ?  369 GLY A H    1 
ATOM   4649 D D    B GLY A 1 288 ? 8.91381   -10.46961 -27.50448 0.130 17.39593  ?  369 GLY A D    1 
ATOM   4650 H HA2  . GLY A 1 288 ? 9.33177   -10.75592 -30.40016 1.000 17.56289  ?  369 GLY A HA2  1 
ATOM   4651 H HA3  . GLY A 1 288 ? 10.55548  -10.76971 -29.11481 1.000 17.56289  ?  369 GLY A HA3  1 
ATOM   4652 N N    . THR A 1 289 ? 10.60939  -13.18555 -29.84547 1.000 13.89776  ?  370 THR A N    1 
ATOM   4653 C CA   . THR A 1 289 ? 10.73871  -14.63378 -29.94022 1.000 14.73608  ?  370 THR A CA   1 
ATOM   4654 C C    . THR A 1 289 ? 10.44212  -15.26700 -28.60247 1.000 14.52638  ?  370 THR A C    1 
ATOM   4655 O O    . THR A 1 289 ? 10.96331  -14.82767 -27.56599 1.000 14.23935  ?  370 THR A O    1 
ATOM   4656 C CB   . THR A 1 289 ? 12.18370  -14.94050 -30.36204 1.000 17.37802  ?  370 THR A CB   1 
ATOM   4657 O OG1  . THR A 1 289 ? 12.45674  -14.29805 -31.62640 1.000 18.66885  ?  370 THR A OG1  1 
ATOM   4658 C CG2  . THR A 1 289 ? 12.46725  -16.41134 -30.45831 1.000 18.08144  ?  370 THR A CG2  1 
ATOM   4659 H H    A THR A 1 289 ? 11.43062  -12.67965 -30.17722 0.000 16.67731  ?  370 THR A H    1 
ATOM   4660 D D    B THR A 1 289 ? 11.43118  -12.68073 -30.17748 1.000 16.67731  ?  370 THR A D    1 
ATOM   4661 H HA   . THR A 1 289 ? 10.04393  -15.04695 -30.67144 1.000 17.68329  ?  370 THR A HA   1 
ATOM   4662 H HB   . THR A 1 289 ? 12.85422  -14.55550 -29.59375 1.000 20.85362  ?  370 THR A HB   1 
ATOM   4663 H HG21 . THR A 1 289 ? 12.74867  -16.67074 -31.47890 1.000 21.69773  ?  370 THR A HG21 1 
ATOM   4664 H HG22 . THR A 1 289 ? 13.28386  -16.67827 -29.78749 1.000 21.69773  ?  370 THR A HG22 1 
ATOM   4665 H HG23 . THR A 1 289 ? 11.58048  -16.98093 -30.18026 1.000 21.69773  ?  370 THR A HG23 1 
ATOM   4666 N N    . ARG A 1 290 ? 9.63402   -16.32202 -28.60943 1.000 13.70186  ?  371 ARG A N    1 
ATOM   4667 C CA   . ARG A 1 290 ? 9.26507   -16.97103 -27.36666 1.000 16.25250  ?  371 ARG A CA   1 
ATOM   4668 C C    . ARG A 1 290 ? 10.44816  -17.76465 -26.81602 1.000 14.08524  ?  371 ARG A C    1 
ATOM   4669 O O    . ARG A 1 290 ? 11.34205  -18.18694 -27.56540 1.000 14.43285  ?  371 ARG A O    1 
ATOM   4670 C CB   . ARG A 1 290 ? 8.06165   -17.90327 -27.56668 1.000 17.58281  ?  371 ARG A CB   1 
ATOM   4671 C CG   . ARG A 1 290 ? 6.70229   -17.21167 -27.27303 1.000 27.82546  ?  371 ARG A CG   1 
ATOM   4672 C CD   . ARG A 1 290 ? 6.54109   -15.90095 -27.99885 1.000 28.30095  ?  371 ARG A CD   1 
ATOM   4673 N NE   . ARG A 1 290 ? 5.68561   -16.09192 -29.13681 1.000 36.15628  ?  371 ARG A NE   1 
ATOM   4674 C CZ   . ARG A 1 290 ? 5.41954   -15.19511 -30.08088 1.000 30.25463  ?  371 ARG A CZ   1 
ATOM   4675 N NH1  . ARG A 1 290 ? 6.07703   -14.02079 -30.16880 1.000 22.22580  ?  371 ARG A NH1  1 
ATOM   4676 N NH2  . ARG A 1 290 ? 4.46448   -15.47895 -30.95749 1.000 32.30944  ?  371 ARG A NH2  1 
ATOM   4677 H H    A ARG A 1 290 ? 9.22753   -16.74085 -29.44594 0.080 16.44223  ?  371 ARG A H    1 
ATOM   4678 D D    B ARG A 1 290 ? 9.22664   -16.74215 -29.44486 0.920 16.44223  ?  371 ARG A D    1 
ATOM   4679 H HA   . ARG A 1 290 ? 8.98150   -16.21377 -26.63573 1.000 19.50300  ?  371 ARG A HA   1 
ATOM   4680 H HB2  . ARG A 1 290 ? 8.04803   -18.24604 -28.60130 1.000 21.09937  ?  371 ARG A HB2  1 
ATOM   4681 H HB3  . ARG A 1 290 ? 8.15821   -18.75477 -26.89309 1.000 21.09937  ?  371 ARG A HB3  1 
ATOM   4682 H HG2  . ARG A 1 290 ? 5.89340   -17.87117 -27.58742 1.000 33.39055  ?  371 ARG A HG2  1 
ATOM   4683 H HG3  . ARG A 1 290 ? 6.62821   -17.01448 -26.20358 1.000 33.39055  ?  371 ARG A HG3  1 
ATOM   4684 H HD2  . ARG A 1 290 ? 6.08811   -15.16372 -27.33597 1.000 33.96114  ?  371 ARG A HD2  1 
ATOM   4685 H HD3  . ARG A 1 290 ? 7.51262   -15.54601 -28.34271 1.000 33.96114  ?  371 ARG A HD3  1 
ATOM   4686 H HE   . ARG A 1 290 ? 5.23902   -17.00428 -29.22929 0.000 43.38754  ?  371 ARG A HE   1 
ATOM   4687 H HH11 . ARG A 1 290 ? 6.80873   -13.79429 -29.49523 0.000 26.67096  ?  371 ARG A HH11 1 
ATOM   4688 H HH12 . ARG A 1 290 ? 5.84256   -13.35918 -30.90887 0.000 26.67096  ?  371 ARG A HH12 1 
ATOM   4689 H HH21 . ARG A 1 290 ? 3.96012   -16.36323 -30.89374 0.000 38.77133  ?  371 ARG A HH21 1 
ATOM   4690 H HH22 . ARG A 1 290 ? 4.23478   -14.81283 -31.69500 0.000 38.77133  ?  371 ARG A HH22 1 
ATOM   4691 N N    . PRO A 1 291 ? 10.46069  -17.98947 -25.51257 1.000 12.04479  ?  372 PRO A N    1 
ATOM   4692 C CA   . PRO A 1 291 ? 11.57678  -18.73523 -24.90535 1.000 13.01020  ?  372 PRO A CA   1 
ATOM   4693 C C    . PRO A 1 291 ? 11.78596  -20.08651 -25.55167 1.000 13.70352  ?  372 PRO A C    1 
ATOM   4694 O O    . PRO A 1 291 ? 10.83719  -20.81677 -25.82186 1.000 14.68414  ?  372 PRO A O    1 
ATOM   4695 C CB   . PRO A 1 291 ? 11.14543  -18.86917 -23.44559 1.000 14.11714  ?  372 PRO A CB   1 
ATOM   4696 C CG   . PRO A 1 291 ? 10.31575  -17.62917 -23.24172 1.000 14.69876  ?  372 PRO A CG   1 
ATOM   4697 C CD   . PRO A 1 291 ? 9.50132   -17.50913 -24.50003 1.000 12.42705  ?  372 PRO A CD   1 
ATOM   4698 H HA   . PRO A 1 291 ? 12.50009  -18.16051 -24.97815 1.000 15.61224  ?  372 PRO A HA   1 
ATOM   4699 H HB2  . PRO A 1 291 ? 10.55572  -19.77451 -23.30171 1.000 16.94056  ?  372 PRO A HB2  1 
ATOM   4700 H HB3  . PRO A 1 291 ? 12.01510  -18.88240 -22.78862 1.000 16.94056  ?  372 PRO A HB3  1 
ATOM   4701 H HG2  . PRO A 1 291 ? 9.67319   -17.74875 -22.36942 1.000 17.63851  ?  372 PRO A HG2  1 
ATOM   4702 H HG3  . PRO A 1 291 ? 10.96433  -16.76293 -23.11106 1.000 17.63851  ?  372 PRO A HG3  1 
ATOM   4703 H HD2  . PRO A 1 291 ? 8.61561   -18.14324 -24.46090 1.000 14.91246  ?  372 PRO A HD2  1 
ATOM   4704 H HD3  . PRO A 1 291 ? 9.21159   -16.47520 -24.68753 1.000 14.91246  ?  372 PRO A HD3  1 
ATOM   4705 N N    . THR A 1 292 ? 13.05323  -20.41966 -25.78851 1.000 13.10725  ?  373 THR A N    1 
ATOM   4706 C CA   . THR A 1 292 ? 13.42040  -21.67146 -26.43134 1.000 13.66204  ?  373 THR A CA   1 
ATOM   4707 C C    . THR A 1 292 ? 14.90413  -21.93710 -26.22639 1.000 12.15590  ?  373 THR A C    1 
ATOM   4708 O O    . THR A 1 292 ? 15.70607  -21.01081 -26.18022 1.000 13.00520  ?  373 THR A O    1 
ATOM   4709 C CB   . THR A 1 292 ? 13.13078  -21.62702 -27.94248 1.000 14.52520  ?  373 THR A CB   1 
ATOM   4710 O OG1  . THR A 1 292 ? 13.47880  -22.91131 -28.52489 1.000 16.95213  ?  373 THR A OG1  1 
ATOM   4711 C CG2  . THR A 1 292 ? 13.88030  -20.51499 -28.63027 1.000 14.80510  ?  373 THR A CG2  1 
ATOM   4712 H H    A THR A 1 292 ? 13.85296  -19.83595 -25.54333 0.490 15.72869  ?  373 THR A H    1 
ATOM   4713 D D    B THR A 1 292 ? 13.85304  -19.83604 -25.54338 0.510 15.72869  ?  373 THR A D    1 
ATOM   4714 H HA   . THR A 1 292 ? 12.85188  -22.47781 -25.96800 1.000 16.39445  ?  373 THR A HA   1 
ATOM   4715 H HB   . THR A 1 292 ? 12.07153  -21.42523 -28.10180 1.000 17.43024  ?  373 THR A HB   1 
ATOM   4716 H HG21 . THR A 1 292 ? 14.90967  -20.82001 -28.81858 1.000 17.76612  ?  373 THR A HG21 1 
ATOM   4717 H HG22 . THR A 1 292 ? 13.40284  -20.27558 -29.58043 1.000 17.76612  ?  373 THR A HG22 1 
ATOM   4718 H HG23 . THR A 1 292 ? 13.88461  -19.62415 -28.00217 1.000 17.76612  ?  373 THR A HG23 1 
ATOM   4719 N N    . THR A 1 293 ? 15.26330  -23.21565 -26.15655 1.000 13.04091  ?  374 THR A N    1 
ATOM   4720 C CA   . THR A 1 293 ? 16.65948  -23.62131 -26.18649 1.000 13.63427  ?  374 THR A CA   1 
ATOM   4721 C C    . THR A 1 293 ? 17.18841  -23.85309 -27.59742 1.000 15.88721  ?  374 THR A C    1 
ATOM   4722 O O    . THR A 1 293 ? 18.37010  -24.16905 -27.75088 1.000 16.61028  ?  374 THR A O    1 
ATOM   4723 C CB   . THR A 1 293 ? 16.87967  -24.86759 -25.34728 1.000 15.08838  ?  374 THR A CB   1 
ATOM   4724 O OG1  . THR A 1 293 ? 16.06569  -25.94383 -25.85125 1.000 19.79123  ?  374 THR A OG1  1 
ATOM   4725 C CG2  . THR A 1 293 ? 16.52571  -24.62632 -23.91647 1.000 15.31017  ?  374 THR A CG2  1 
ATOM   4726 H H    A THR A 1 293 ? 14.60664  -23.99226 -26.07860 0.090 15.64910  ?  374 THR A H    1 
ATOM   4727 D D    B THR A 1 293 ? 14.60568  -23.99145 -26.07861 0.910 15.64910  ?  374 THR A D    1 
ATOM   4728 H HA   . THR A 1 293 ? 17.24824  -22.82068 -25.73878 1.000 16.36113  ?  374 THR A HA   1 
ATOM   4729 H HB   . THR A 1 293 ? 17.93337  -25.14182 -25.39841 1.000 18.10605  ?  374 THR A HB   1 
ATOM   4730 H HG21 . THR A 1 293 ? 17.03737  -23.73601 -23.55087 1.000 18.37220  ?  374 THR A HG21 1 
ATOM   4731 H HG22 . THR A 1 293 ? 15.44987  -24.48162 -23.81786 1.000 18.37220  ?  374 THR A HG22 1 
ATOM   4732 H HG23 . THR A 1 293 ? 16.82485  -25.48067 -23.30925 1.000 18.37220  ?  374 THR A HG23 1 
ATOM   4733 N N    A ASN A 1 294 ? 16.34905  -23.69851 -28.61456 0.570 14.27608  ?  375 ASN A N    1 
ATOM   4734 N N    B ASN A 1 294 ? 16.36537  -23.67819 -28.62175 0.430 14.37033  ?  375 ASN A N    1 
ATOM   4735 C CA   A ASN A 1 294 ? 16.76793  -23.72023 -30.01910 0.570 17.36372  ?  375 ASN A CA   1 
ATOM   4736 C CA   B ASN A 1 294 ? 16.82383  -23.76951 -30.00951 0.430 17.45554  ?  375 ASN A CA   1 
ATOM   4737 C C    A ASN A 1 294 ? 17.23067  -22.31683 -30.39621 0.570 17.28370  ?  375 ASN A C    1 
ATOM   4738 C C    B ASN A 1 294 ? 17.25962  -22.37729 -30.45832 0.430 16.89829  ?  375 ASN A C    1 
ATOM   4739 O O    A ASN A 1 294 ? 16.48997  -21.48711 -30.92871 0.570 21.94368  ?  375 ASN A O    1 
ATOM   4740 O O    B ASN A 1 294 ? 16.53607  -21.62980 -31.11173 0.430 22.44716  ?  375 ASN A O    1 
ATOM   4741 C CB   A ASN A 1 294 ? 15.59161  -24.15004 -30.88838 0.570 20.69573  ?  375 ASN A CB   1 
ATOM   4742 C CB   B ASN A 1 294 ? 15.72010  -24.35466 -30.88094 0.430 20.32206  ?  375 ASN A CB   1 
ATOM   4743 C CG   A ASN A 1 294 ? 15.99695  -24.49688 -32.30189 0.570 29.82252  ?  375 ASN A CG   1 
ATOM   4744 C CG   B ASN A 1 294 ? 15.33710  -25.76113 -30.45476 0.430 23.16083  ?  375 ASN A CG   1 
ATOM   4745 O OD1  A ASN A 1 294 ? 17.12829  -24.24642 -32.71762 0.570 30.90036  ?  375 ASN A OD1  1 
ATOM   4746 O OD1  B ASN A 1 294 ? 16.19424  -26.53884 -30.03855 0.430 28.64662  ?  375 ASN A OD1  1 
ATOM   4747 N ND2  A ASN A 1 294 ? 15.06816  -25.08090 -33.05218 0.570 33.33330  ?  375 ASN A ND2  1 
ATOM   4748 N ND2  B ASN A 1 294 ? 14.04783  -26.09534 -30.55614 0.430 27.78297  ?  375 ASN A ND2  1 
ATOM   4749 H H    A ASN A 1 294 ? 15.34605  -23.55234 -28.50038 0.000 17.13129  ?  375 ASN A H    1 
ATOM   4750 D D    B ASN A 1 294 ? 15.37109  -23.47106 -28.52737 1.000 17.24440  ?  375 ASN A D    1 
ATOM   4751 H HA   A ASN A 1 294 ? 17.59755  -24.41481 -30.15095 0.570 20.83647  ?  375 ASN A HA   1 
ATOM   4752 H HA   B ASN A 1 294 ? 17.69121  -24.42598 -30.07878 0.430 20.94665  ?  375 ASN A HA   1 
ATOM   4753 H HB2  A ASN A 1 294 ? 15.12812  -25.03187 -30.44605 0.570 24.83488  ?  375 ASN A HB2  1 
ATOM   4754 H HB2  B ASN A 1 294 ? 14.83402  -23.72420 -30.80698 0.430 24.38647  ?  375 ASN A HB2  1 
ATOM   4755 H HB3  A ASN A 1 294 ? 14.87030  -23.33427 -30.93653 0.570 24.83488  ?  375 ASN A HB3  1 
ATOM   4756 H HB3  B ASN A 1 294 ? 16.06393  -24.39472 -31.91451 0.430 24.38647  ?  375 ASN A HB3  1 
ATOM   4757 N N    . THR A 1 295 ? 18.47984  -22.02073 -30.07718 1.000 15.74883  ?  376 THR A N    1 
ATOM   4758 C CA   . THR A 1 295 ? 18.97069  -20.65786 -30.16754 1.000 16.05233  ?  376 THR A CA   1 
ATOM   4759 C C    . THR A 1 295 ? 19.83481  -20.40114 -31.39584 1.000 18.49686  ?  376 THR A C    1 
ATOM   4760 O O    . THR A 1 295 ? 20.11484  -19.24584 -31.69159 1.000 21.98317  ?  376 THR A O    1 
ATOM   4761 C CB   . THR A 1 295 ? 19.84781  -20.35852 -28.93294 1.000 15.58379  ?  376 THR A CB   1 
ATOM   4762 O OG1  . THR A 1 295 ? 20.99328  -21.23120 -28.96723 1.000 15.53351  ?  376 THR A OG1  1 
ATOM   4763 C CG2  . THR A 1 295 ? 19.09630  -20.57285 -27.60285 1.000 16.57427  ?  376 THR A CG2  1 
ATOM   4764 H H    A THR A 1 295 ? 19.17101  -22.69817 -29.75506 0.000 18.89859  ?  376 THR A H    1 
ATOM   4765 D D    B THR A 1 295 ? 19.16568  -22.67069 -29.69302 1.000 18.89859  ?  376 THR A D    1 
ATOM   4766 H HA   . THR A 1 295 ? 18.11543  -19.98281 -30.19842 1.000 19.26280  ?  376 THR A HA   1 
ATOM   4767 H HB   . THR A 1 295 ? 20.14597  -19.31048 -28.96157 1.000 18.70055  ?  376 THR A HB   1 
ATOM   4768 H HG1  C THR A 1 295 ? 21.68222  -20.90433 -28.35167 0.000 18.64021  ?  376 THR A HG1  1 
ATOM   4769 D DG1  D THR A 1 295 ? 21.64421  -20.95673 -28.28799 1.000 18.64021  ?  376 THR A DG1  1 
ATOM   4770 H HG21 . THR A 1 295 ? 18.93064  -21.63712 -27.43557 1.000 19.88912  ?  376 THR A HG21 1 
ATOM   4771 H HG22 . THR A 1 295 ? 19.68127  -20.17154 -26.77529 1.000 19.88912  ?  376 THR A HG22 1 
ATOM   4772 H HG23 . THR A 1 295 ? 18.13218  -20.06529 -27.63342 1.000 19.88912  ?  376 THR A HG23 1 
ATOM   4773 N N    . GLY A 1 296 ? 20.34706  -21.44205 -32.03970 1.000 18.27440  ?  377 GLY A N    1 
ATOM   4774 C CA   . GLY A 1 296 ? 21.20277  -21.25612 -33.18580 1.000 19.20244  ?  377 GLY A CA   1 
ATOM   4775 C C    . GLY A 1 296 ? 22.62317  -20.88403 -32.87086 1.000 17.78377  ?  377 GLY A C    1 
ATOM   4776 O O    . GLY A 1 296 ? 23.40880  -20.63335 -33.80409 1.000 20.28624  ?  377 GLY A O    1 
ATOM   4777 H H    A GLY A 1 296 ? 20.18409  -22.41672 -31.78701 0.050 21.92928  ?  377 GLY A H    1 
ATOM   4778 D D    B GLY A 1 296 ? 20.18385  -22.41660 -31.78669 0.950 21.92928  ?  377 GLY A D    1 
ATOM   4779 H HA2  . GLY A 1 296 ? 21.22309  -22.18359 -33.75808 1.000 23.04293  ?  377 GLY A HA2  1 
ATOM   4780 H HA3  . GLY A 1 296 ? 20.78372  -20.46476 -33.80729 1.000 23.04293  ?  377 GLY A HA3  1 
ATOM   4781 N N    . SER A 1 297 ? 23.01181  -20.83183 -31.60376 1.000 15.42070  ?  378 SER A N    1 
ATOM   4782 C CA   . SER A 1 297 ? 24.35294  -20.42166 -31.23509 1.000 16.09387  ?  378 SER A CA   1 
ATOM   4783 C C    . SER A 1 297 ? 24.92272  -21.35263 -30.18506 1.000 16.69096  ?  378 SER A C    1 
ATOM   4784 O O    . SER A 1 297 ? 24.23780  -21.69947 -29.21387 1.000 16.37676  ?  378 SER A O    1 
ATOM   4785 C CB   . SER A 1 297 ? 24.34462  -19.00226 -30.64175 1.000 17.20394  ?  378 SER A CB   1 
ATOM   4786 O OG   . SER A 1 297 ? 25.61318  -18.68696 -30.05383 1.000 18.85861  ?  378 SER A OG   1 
ATOM   4787 H H    A SER A 1 297 ? 22.41561  -21.06914 -30.81090 0.000 18.50484  ?  378 SER A H    1 
ATOM   4788 D D    B SER A 1 297 ? 22.41419  -21.06953 -30.81209 1.000 18.50484  ?  378 SER A D    1 
ATOM   4789 H HA   . SER A 1 297 ? 24.98165  -20.46293 -32.12454 1.000 19.31264  ?  378 SER A HA   1 
ATOM   4790 H HB2  . SER A 1 297 ? 24.13450  -18.28676 -31.43674 1.000 20.64472  ?  378 SER A HB2  1 
ATOM   4791 H HB3  . SER A 1 297 ? 23.57335  -18.94340 -29.87378 1.000 20.64472  ?  378 SER A HB3  1 
ATOM   4792 H HG   A SER A 1 297 ? 26.30668  -18.66310 -30.74586 0.000 22.63033  ?  378 SER A HG   1 
ATOM   4793 D DG   B SER A 1 297 ? 26.32870  -18.81727 -30.71069 1.000 22.63033  ?  378 SER A DG   1 
ATOM   4794 N N    A GLN A 1 298 ? 26.18394  -21.76041 -30.38054 0.600 15.85839  ?  379 GLN A N    1 
ATOM   4795 N N    B GLN A 1 298 ? 26.20026  -21.70709 -30.37971 0.400 16.10228  ?  379 GLN A N    1 
ATOM   4796 C CA   A GLN A 1 298 ? 26.89458  -22.56645 -29.39611 0.600 18.03990  ?  379 GLN A CA   1 
ATOM   4797 C CA   B GLN A 1 298 ? 26.91908  -22.55218 -29.44138 0.400 17.87217  ?  379 GLN A CA   1 
ATOM   4798 C C    A GLN A 1 298 ? 26.86483  -21.91627 -28.01107 0.600 15.55678  ?  379 GLN A C    1 
ATOM   4799 C C    B GLN A 1 298 ? 27.07048  -21.90220 -28.06806 0.400 16.40508  ?  379 GLN A C    1 
ATOM   4800 O O    A GLN A 1 298 ? 26.82284  -22.60816 -26.98945 0.600 18.04489  ?  379 GLN A O    1 
ATOM   4801 O O    B GLN A 1 298 ? 27.36568  -22.60142 -27.09836 0.400 20.22500  ?  379 GLN A O    1 
ATOM   4802 C CB   A GLN A 1 298 ? 28.34906  -22.76541 -29.87312 0.600 19.88665  ?  379 GLN A CB   1 
ATOM   4803 C CB   B GLN A 1 298 ? 28.30575  -22.90683 -30.01706 0.400 21.01880  ?  379 GLN A CB   1 
ATOM   4804 C CG   A GLN A 1 298 ? 29.20216  -23.70181 -29.03445 0.600 25.12699  ?  379 GLN A CG   1 
ATOM   4805 C CG   B GLN A 1 298 ? 29.24193  -21.72232 -30.26530 0.400 20.91762  ?  379 GLN A CG   1 
ATOM   4806 C CD   A GLN A 1 298 ? 30.52414  -24.07843 -29.73307 0.600 41.17225  ?  379 GLN A CD   1 
ATOM   4807 C CD   B GLN A 1 298 ? 30.19150  -21.95240 -31.44107 0.400 28.71440  ?  379 GLN A CD   1 
ATOM   4808 O OE1  A GLN A 1 298 ? 31.05214  -23.29628 -30.52595 0.600 29.83017  ?  379 GLN A OE1  1 
ATOM   4809 O OE1  B GLN A 1 298 ? 30.49694  -21.02865 -32.19608 0.400 30.78274  ?  379 GLN A OE1  1 
ATOM   4810 N NE2  A GLN A 1 298 ? 31.03741  -25.28512 -29.46162 0.600 24.00331  ?  379 GLN A NE2  1 
ATOM   4811 N NE2  B GLN A 1 298 ? 30.65968  -23.18455 -31.59529 0.400 30.95255  ?  379 GLN A NE2  1 
ATOM   4812 H H    A GLN A 1 298 ? 26.73579  -21.54650 -31.21127 0.090 19.03007  ?  379 GLN A H    1 
ATOM   4813 D D    B GLN A 1 298 ? 26.76138  -21.42108 -31.18204 0.910 19.32273  ?  379 GLN A D    1 
ATOM   4814 H HA   A GLN A 1 298 ? 26.42175  -23.54450 -29.30693 0.600 21.64788  ?  379 GLN A HA   1 
ATOM   4815 H HA   B GLN A 1 298 ? 26.36076  -23.47827 -29.30445 0.400 21.44661  ?  379 GLN A HA   1 
ATOM   4816 H HB2  A GLN A 1 298 ? 28.32340  -23.17180 -30.88420 0.600 23.86398  ?  379 GLN A HB2  1 
ATOM   4817 H HB2  B GLN A 1 298 ? 28.80687  -23.57416 -29.31589 0.400 25.22256  ?  379 GLN A HB2  1 
ATOM   4818 H HB3  A GLN A 1 298 ? 28.84311  -21.79381 -29.87428 0.600 23.86398  ?  379 GLN A HB3  1 
ATOM   4819 H HB3  B GLN A 1 298 ? 28.16085  -23.41077 -30.97265 0.400 25.22256  ?  379 GLN A HB3  1 
ATOM   4820 H HG2  A GLN A 1 298 ? 29.44516  -23.21359 -28.09069 0.600 30.15239  ?  379 GLN A HG2  1 
ATOM   4821 H HG2  B GLN A 1 298 ? 28.64421  -20.83734 -30.48355 0.400 25.10115  ?  379 GLN A HG2  1 
ATOM   4822 H HG3  A GLN A 1 298 ? 28.64504  -24.61968 -28.84674 0.600 30.15239  ?  379 GLN A HG3  1 
ATOM   4823 H HG3  B GLN A 1 298 ? 29.84532  -21.55397 -29.37329 0.400 25.10115  ?  379 GLN A HG3  1 
ATOM   4824 N N    . PHE A 1 299 ? 26.86149  -20.58980 -27.96013 1.000 14.27489  ?  380 PHE A N    1 
ATOM   4825 C CA   . PHE A 1 299 ? 27.09454  -19.87928 -26.72151 1.000 13.58456  ?  380 PHE A CA   1 
ATOM   4826 C C    . PHE A 1 299 ? 25.81606  -19.57924 -25.97457 1.000 13.29595  ?  380 PHE A C    1 
ATOM   4827 O O    . PHE A 1 299 ? 25.91790  -19.10484 -24.84251 1.000 14.95383  ?  380 PHE A O    1 
ATOM   4828 C CB   . PHE A 1 299 ? 27.79066  -18.54099 -27.00789 1.000 15.89868  ?  380 PHE A CB   1 
ATOM   4829 C CG   . PHE A 1 299 ? 29.09903  -18.68168 -27.73369 1.000 16.64615  ?  380 PHE A CG   1 
ATOM   4830 C CD1  . PHE A 1 299 ? 30.12708  -19.43188 -27.18485 1.000 20.81053  ?  380 PHE A CD1  1 
ATOM   4831 C CD2  . PHE A 1 299 ? 29.29975  -18.05846 -28.95070 1.000 19.68076  ?  380 PHE A CD2  1 
ATOM   4832 C CE1  . PHE A 1 299 ? 31.36370  -19.56945 -27.86819 1.000 25.69997  ?  380 PHE A CE1  1 
ATOM   4833 C CE2  . PHE A 1 299 ? 30.53616  -18.17992 -29.61573 1.000 24.12181  ?  380 PHE A CE2  1 
ATOM   4834 C CZ   . PHE A 1 299 ? 31.55119  -18.94559 -29.06884 1.000 24.35727  ?  380 PHE A CZ   1 
ATOM   4835 H H    A PHE A 1 299 ? 26.69954  -19.98375 -28.76441 0.000 17.12987  ?  380 PHE A H    1 
ATOM   4836 D D    B PHE A 1 299 ? 26.52955  -19.99857 -28.72214 1.000 17.12987  ?  380 PHE A D    1 
ATOM   4837 H HA   . PHE A 1 299 ? 27.74194  -20.48839 -26.09067 1.000 16.30148  ?  380 PHE A HA   1 
ATOM   4838 H HB2  . PHE A 1 299 ? 27.13257  -17.92859 -27.62431 1.000 19.07842  ?  380 PHE A HB2  1 
ATOM   4839 H HB3  . PHE A 1 299 ? 27.98808  -18.03900 -26.06072 1.000 19.07842  ?  380 PHE A HB3  1 
ATOM   4840 H HD1  . PHE A 1 299 ? 29.98621  -19.91568 -26.22961 1.000 24.97264  ?  380 PHE A HD1  1 
ATOM   4841 H HD2  . PHE A 1 299 ? 28.50568  -17.47590 -29.39396 1.000 23.61691  ?  380 PHE A HD2  1 
ATOM   4842 H HE1  . PHE A 1 299 ? 32.15504  -20.16642 -27.43947 1.000 30.83997  ?  380 PHE A HE1  1 
ATOM   4843 H HE2  . PHE A 1 299 ? 30.69246  -17.67317 -30.55657 1.000 28.94617  ?  380 PHE A HE2  1 
ATOM   4844 H HZ   . PHE A 1 299 ? 32.49082  -19.04973 -29.59101 1.000 29.22873  ?  380 PHE A HZ   1 
ATOM   4845 N N    . ILE A 1 300 ? 24.64446  -19.80547 -26.54430 1.000 11.73443  ?  381 ILE A N    1 
ATOM   4846 C CA   . ILE A 1 300 ? 23.39922  -19.35364 -25.92480 1.000 11.92203  ?  381 ILE A CA   1 
ATOM   4847 C C    . ILE A 1 300 ? 22.61026  -20.57708 -25.49966 1.000 11.73857  ?  381 ILE A C    1 
ATOM   4848 O O    . ILE A 1 300 ? 22.14392  -21.34525 -26.34483 1.000 13.27808  ?  381 ILE A O    1 
ATOM   4849 C CB   . ILE A 1 300 ? 22.57861  -18.46618 -26.86913 1.000 12.13077  ?  381 ILE A CB   1 
ATOM   4850 C CG1  . ILE A 1 300 ? 23.41787  -17.28020 -27.32265 1.000 14.71734  ?  381 ILE A CG1  1 
ATOM   4851 C CG2  . ILE A 1 300 ? 21.30527  -18.00094 -26.16562 1.000 13.06633  ?  381 ILE A CG2  1 
ATOM   4852 C CD1  . ILE A 1 300 ? 22.67447  -16.34089 -28.30109 1.000 15.72904  ?  381 ILE A CD1  1 
ATOM   4853 H H    A ILE A 1 300 ? 24.52080  -20.29592 -27.43006 0.780 14.08131  ?  381 ILE A H    1 
ATOM   4854 D D    B ILE A 1 300 ? 24.52331  -20.29623 -27.43024 0.220 14.08131  ?  381 ILE A D    1 
ATOM   4855 H HA   . ILE A 1 300 ? 23.63705  -18.77372 -25.03305 1.000 14.30643  ?  381 ILE A HA   1 
ATOM   4856 H HB   . ILE A 1 300 ? 22.29467  -19.04108 -27.75059 1.000 14.55692  ?  381 ILE A HB   1 
ATOM   4857 H HG12 . ILE A 1 300 ? 23.70218  -16.69503 -26.44810 1.000 17.66081  ?  381 ILE A HG12 1 
ATOM   4858 H HG13 . ILE A 1 300 ? 24.30907  -17.65221 -27.82810 1.000 17.66081  ?  381 ILE A HG13 1 
ATOM   4859 H HG21 . ILE A 1 300 ? 21.56688  -17.60175 -25.18567 1.000 15.67960  ?  381 ILE A HG21 1 
ATOM   4860 H HG22 . ILE A 1 300 ? 20.82996  -17.22651 -26.76764 1.000 15.67960  ?  381 ILE A HG22 1 
ATOM   4861 H HG23 . ILE A 1 300 ? 20.63141  -18.85028 -26.05318 1.000 15.67960  ?  381 ILE A HG23 1 
ATOM   4862 H HD11 . ILE A 1 300 ? 22.60059  -16.82789 -29.27345 1.000 18.87485  ?  381 ILE A HD11 1 
ATOM   4863 H HD12 . ILE A 1 300 ? 21.67737  -16.13839 -27.91008 1.000 18.87485  ?  381 ILE A HD12 1 
ATOM   4864 H HD13 . ILE A 1 300 ? 23.23376  -15.40987 -28.39322 1.000 18.87485  ?  381 ILE A HD13 1 
ATOM   4865 N N    . ASP A 1 301 ? 22.40455  -20.72335 -24.19703 1.000 11.13722  ?  382 ASP A N    1 
ATOM   4866 C CA   . ASP A 1 301 ? 21.61622  -21.80638 -23.63425 1.000 11.87146  ?  382 ASP A CA   1 
ATOM   4867 C C    . ASP A 1 301 ? 20.13158  -21.62987 -23.90240 1.000 12.56792  ?  382 ASP A C    1 
ATOM   4868 O O    . ASP A 1 301 ? 19.41669  -22.60677 -24.12331 1.000 12.91647  ?  382 ASP A O    1 
ATOM   4869 C CB   . ASP A 1 301 ? 21.83959  -21.87134 -22.13761 1.000 11.17742  ?  382 ASP A CB   1 
ATOM   4870 C CG   . ASP A 1 301 ? 23.19384  -22.40648 -21.75347 1.000 13.28760  ?  382 ASP A CG   1 
ATOM   4871 O OD1  . ASP A 1 301 ? 23.80355  -23.17134 -22.53604 1.000 15.52270  ?  382 ASP A OD1  1 
ATOM   4872 O OD2  . ASP A 1 301 ? 23.67373  -22.05707 -20.65669 1.000 13.14223  -1 382 ASP A OD2  1 
ATOM   4873 H H    A ASP A 1 301 ? 22.77925  -20.09333 -23.48775 1.000 13.36466  ?  382 ASP A H    1 
ATOM   4874 D D    B ASP A 1 301 ? 22.77803  -20.09487 -23.48574 0.000 13.36466  ?  382 ASP A D    1 
ATOM   4875 H HA   . ASP A 1 301 ? 21.94294  -22.73716 -24.09794 1.000 14.24575  ?  382 ASP A HA   1 
ATOM   4876 H HB2  . ASP A 1 301 ? 21.74896  -20.86670 -21.72458 1.000 13.41291  ?  382 ASP A HB2  1 
ATOM   4877 H HB3  . ASP A 1 301 ? 21.08616  -22.52468 -21.69762 1.000 13.41291  ?  382 ASP A HB3  1 
ATOM   4878 N N    . SER A 1 302 ? 19.61812  -20.39221 -23.82147 1.000 11.58240  ?  383 SER A N    1 
ATOM   4879 C CA   . SER A 1 302 ? 18.19685  -20.14872 -24.02361 1.000 11.03303  ?  383 SER A CA   1 
ATOM   4880 C C    . SER A 1 302 ? 17.92589  -18.70023 -24.37519 1.000 10.60815  ?  383 SER A C    1 
ATOM   4881 O O    . SER A 1 302 ? 18.57899  -17.78590 -23.84214 1.000 12.45484  ?  383 SER A O    1 
ATOM   4882 C CB   . SER A 1 302 ? 17.42634  -20.51779 -22.75616 1.000 12.93050  ?  383 SER A CB   1 
ATOM   4883 O OG   . SER A 1 302 ? 16.03605  -20.61014 -23.01268 1.000 14.48375  ?  383 SER A OG   1 
ATOM   4884 H H    A SER A 1 302 ? 20.16233  -19.55354 -23.61929 1.000 13.89888  ?  383 SER A H    1 
ATOM   4885 D D    B SER A 1 302 ? 20.16231  -19.55353 -23.61929 0.000 13.89888  ?  383 SER A D    1 
ATOM   4886 H HA   . SER A 1 302 ? 17.85963  -20.74307 -24.87280 1.000 13.23964  ?  383 SER A HA   1 
ATOM   4887 H HB2  . SER A 1 302 ? 17.78368  -21.48142 -22.39309 1.000 15.51660  ?  383 SER A HB2  1 
ATOM   4888 H HB3  . SER A 1 302 ? 17.59653  -19.74901 -22.00242 1.000 15.51660  ?  383 SER A HB3  1 
ATOM   4889 H HG   A SER A 1 302 ? 15.62831  -19.71980 -22.97454 0.020 17.38050  ?  383 SER A HG   1 
ATOM   4890 D DG   B SER A 1 302 ? 15.65388  -19.71359 -23.11541 0.980 17.38050  ?  383 SER A DG   1 
ATOM   4891 N N    . ILE A 1 303 ? 16.97355  -18.50685 -25.27319 1.000 11.19248  ?  384 ILE A N    1 
ATOM   4892 C CA   . ILE A 1 303 ? 16.19819  -17.27015 -25.34866 1.000 11.15272  ?  384 ILE A CA   1 
ATOM   4893 C C    . ILE A 1 303 ? 15.17930  -17.29719 -24.21780 1.000 10.57871  ?  384 ILE A C    1 
ATOM   4894 O O    . ILE A 1 303 ? 14.55170  -18.32523 -23.98295 1.000 11.77919  ?  384 ILE A O    1 
ATOM   4895 C CB   . ILE A 1 303 ? 15.52757  -17.15695 -26.72592 1.000 11.62516  ?  384 ILE A CB   1 
ATOM   4896 C CG1  . ILE A 1 303 ? 16.61474  -17.10095 -27.80720 1.000 15.48721  ?  384 ILE A CG1  1 
ATOM   4897 C CG2  . ILE A 1 303 ? 14.58828  -15.98353 -26.76391 1.000 14.96110  ?  384 ILE A CG2  1 
ATOM   4898 C CD1  . ILE A 1 303 ? 16.07035  -17.26989 -29.20168 1.000 20.33697  ?  384 ILE A CD1  1 
ATOM   4899 H H    A ILE A 1 303 ? 16.70639  -19.19560 -25.97650 0.820 13.43098  ?  384 ILE A H    1 
ATOM   4900 D D    B ILE A 1 303 ? 16.70633  -19.19555 -25.97653 0.180 13.43098  ?  384 ILE A D    1 
ATOM   4901 H HA   . ILE A 1 303 ? 16.83885  -16.39823 -25.21676 1.000 13.38327  ?  384 ILE A HA   1 
ATOM   4902 H HB   . ILE A 1 303 ? 14.91446  -18.03695 -26.92035 1.000 13.95019  ?  384 ILE A HB   1 
ATOM   4903 H HG12 . ILE A 1 303 ? 17.11403  -16.13335 -27.75650 1.000 18.58466  ?  384 ILE A HG12 1 
ATOM   4904 H HG13 . ILE A 1 303 ? 17.33303  -17.90095 -27.62786 1.000 18.58466  ?  384 ILE A HG13 1 
ATOM   4905 H HG21 . ILE A 1 303 ? 13.56255  -16.34810 -26.70842 1.000 17.95332  ?  384 ILE A HG21 1 
ATOM   4906 H HG22 . ILE A 1 303 ? 14.79812  -15.33336 -25.91459 1.000 17.95332  ?  384 ILE A HG22 1 
ATOM   4907 H HG23 . ILE A 1 303 ? 14.73907  -15.43828 -27.69560 1.000 17.95332  ?  384 ILE A HG23 1 
ATOM   4908 H HD11 . ILE A 1 303 ? 15.26058  -16.55661 -29.35533 1.000 24.40436  ?  384 ILE A HD11 1 
ATOM   4909 H HD12 . ILE A 1 303 ? 16.86959  -17.08516 -29.91944 1.000 24.40436  ?  384 ILE A HD12 1 
ATOM   4910 H HD13 . ILE A 1 303 ? 15.69616  -18.28727 -29.31572 1.000 24.40436  ?  384 ILE A HD13 1 
ATOM   4911 N N    . VAL A 1 304 ? 15.08171  -16.19787 -23.47197 1.000 10.33801  ?  385 VAL A N    1 
ATOM   4912 C CA   . VAL A 1 304 ? 14.21347  -16.12843 -22.29615 1.000 10.98781  ?  385 VAL A CA   1 
ATOM   4913 C C    . VAL A 1 304 ? 13.40705  -14.83293 -22.34597 1.000 9.86674   ?  385 VAL A C    1 
ATOM   4914 O O    . VAL A 1 304 ? 13.68270  -13.92628 -23.13318 1.000 11.01564  ?  385 VAL A O    1 
ATOM   4915 C CB   . VAL A 1 304 ? 15.03295  -16.19243 -20.98748 1.000 10.88566  ?  385 VAL A CB   1 
ATOM   4916 C CG1  . VAL A 1 304 ? 15.64145  -17.58742 -20.81087 1.000 12.35011  ?  385 VAL A CG1  1 
ATOM   4917 C CG2  . VAL A 1 304 ? 16.14515  -15.12573 -21.01133 1.000 11.83383  ?  385 VAL A CG2  1 
ATOM   4918 H H    A VAL A 1 304 ? 15.59388  -15.33556 -23.65774 0.940 12.40561  ?  385 VAL A H    1 
ATOM   4919 D D    B VAL A 1 304 ? 15.59483  -15.33651 -23.65953 0.060 12.40561  ?  385 VAL A D    1 
ATOM   4920 H HA   . VAL A 1 304 ? 13.50971  -16.96040 -22.32172 1.000 13.18537  ?  385 VAL A HA   1 
ATOM   4921 H HB   . VAL A 1 304 ? 14.37540  -15.99380 -20.14115 1.000 13.06279  ?  385 VAL A HB   1 
ATOM   4922 H HG11 . VAL A 1 304 ? 14.94813  -18.20769 -20.24283 1.000 14.82013  ?  385 VAL A HG11 1 
ATOM   4923 H HG12 . VAL A 1 304 ? 15.81353  -18.02653 -21.79356 1.000 14.82013  ?  385 VAL A HG12 1 
ATOM   4924 H HG13 . VAL A 1 304 ? 16.58550  -17.49736 -20.27351 1.000 14.82013  ?  385 VAL A HG13 1 
ATOM   4925 H HG21 . VAL A 1 304 ? 16.82926  -15.34461 -21.83119 1.000 14.20060  ?  385 VAL A HG21 1 
ATOM   4926 H HG22 . VAL A 1 304 ? 15.69287  -14.14467 -21.15646 1.000 14.20060  ?  385 VAL A HG22 1 
ATOM   4927 H HG23 . VAL A 1 304 ? 16.68157  -15.15108 -20.06279 1.000 14.20060  ?  385 VAL A HG23 1 
ATOM   4928 N N    . TRP A 1 305 ? 12.38043  -14.76709 -21.48825 1.000 9.57765   ?  386 TRP A N    1 
ATOM   4929 C CA   . TRP A 1 305 ? 11.63401  -13.53966 -21.23598 1.000 10.17884  ?  386 TRP A CA   1 
ATOM   4930 C C    . TRP A 1 305 ? 11.87422  -13.16980 -19.78310 1.000 10.40437  ?  386 TRP A C    1 
ATOM   4931 O O    . TRP A 1 305 ? 11.28649  -13.77144 -18.87365 1.000 11.79897  ?  386 TRP A O    1 
ATOM   4932 C CB   . TRP A 1 305 ? 10.13673  -13.73247 -21.49165 1.000 12.73790  ?  386 TRP A CB   1 
ATOM   4933 C CG   . TRP A 1 305 ? 9.72959   -13.71992 -22.92559 1.000 11.96218  ?  386 TRP A CG   1 
ATOM   4934 C CD1  . TRP A 1 305 ? 10.52880  -13.86794 -24.01711 1.000 11.77397  ?  386 TRP A CD1  1 
ATOM   4935 C CD2  . TRP A 1 305 ? 8.39974   -13.54635 -23.40944 1.000 11.67143  ?  386 TRP A CD2  1 
ATOM   4936 N NE1  . TRP A 1 305 ? 9.76173   -13.77246 -25.18165 1.000 12.70981  ?  386 TRP A NE1  1 
ATOM   4937 C CE2  . TRP A 1 305 ? 8.45885   -13.58511 -24.80482 1.000 13.37599  ?  386 TRP A CE2  1 
ATOM   4938 C CE3  . TRP A 1 305 ? 7.17532   -13.35304 -22.78694 1.000 13.78079  ?  386 TRP A CE3  1 
ATOM   4939 C CZ2  . TRP A 1 305 ? 7.31164   -13.43690 -25.62591 1.000 14.61704  ?  386 TRP A CZ2  1 
ATOM   4940 C CZ3  . TRP A 1 305 ? 6.03128   -13.20257 -23.59570 1.000 15.83806  ?  386 TRP A CZ3  1 
ATOM   4941 C CH2  . TRP A 1 305 ? 6.11631   -13.25101 -24.98055 1.000 15.78189  ?  386 TRP A CH2  1 
ATOM   4942 H H    A TRP A 1 305 ? 12.04296  -15.56411 -20.94856 0.760 11.49317  ?  386 TRP A H    1 
ATOM   4943 D D    B TRP A 1 305 ? 12.04482  -15.56564 -20.94966 0.240 11.49317  ?  386 TRP A D    1 
ATOM   4944 H HA   . TRP A 1 305 ? 12.00091  -12.75069 -21.89248 1.000 12.21461  ?  386 TRP A HA   1 
ATOM   4945 H HB2  . TRP A 1 305 ? 9.83815   -14.69530 -21.07704 1.000 15.28548  ?  386 TRP A HB2  1 
ATOM   4946 H HB3  . TRP A 1 305 ? 9.59620   -12.92802 -20.99287 1.000 15.28548  ?  386 TRP A HB3  1 
ATOM   4947 H HD1  . TRP A 1 305 ? 11.59552  -14.03422 -23.98790 1.000 14.12876  ?  386 TRP A HD1  1 
ATOM   4948 H HE1  A TRP A 1 305 ? 10.10953  -13.83163 -26.13870 1.000 15.25178  ?  386 TRP A HE1  1 
ATOM   4949 D DE1  B TRP A 1 305 ? 10.10953  -13.83163 -26.13870 0.000 15.25178  ?  386 TRP A DE1  1 
ATOM   4950 H HE3  . TRP A 1 305 ? 7.10075   -13.31872 -21.71007 1.000 16.53695  ?  386 TRP A HE3  1 
ATOM   4951 H HZ2  . TRP A 1 305 ? 7.37641   -13.46882 -26.70350 1.000 17.54045  ?  386 TRP A HZ2  1 
ATOM   4952 H HZ3  . TRP A 1 305 ? 5.06977   -13.04656 -23.12927 1.000 19.00567  ?  386 TRP A HZ3  1 
ATOM   4953 H HH2  . TRP A 1 305 ? 5.21563   -13.13913 -25.56592 1.000 18.93827  ?  386 TRP A HH2  1 
ATOM   4954 N N    . VAL A 1 306 ? 12.77942  -12.21564 -19.56092 1.000 10.15231  ?  387 VAL A N    1 
ATOM   4955 C CA   . VAL A 1 306 ? 13.20636  -11.88158 -18.19783 1.000 10.17640  ?  387 VAL A CA   1 
ATOM   4956 C C    . VAL A 1 306 ? 12.31204  -10.78141 -17.65546 1.000 10.40204  ?  387 VAL A C    1 
ATOM   4957 O O    . VAL A 1 306 ? 11.61896  -10.97488 -16.64441 1.000 11.56118  ?  387 VAL A O    1 
ATOM   4958 C CB   . VAL A 1 306 ? 14.71440  -11.55325 -18.06901 1.000 9.94563   ?  387 VAL A CB   1 
ATOM   4959 C CG1  . VAL A 1 306 ? 15.08116  -11.39043 -16.62038 1.000 12.23796  ?  387 VAL A CG1  1 
ATOM   4960 C CG2  . VAL A 1 306 ? 15.55332  -12.66188 -18.66191 1.000 13.21780  ?  387 VAL A CG2  1 
ATOM   4961 H H    A VAL A 1 306 ? 13.22937  -11.66386 -20.29133 0.970 12.18277  ?  387 VAL A H    1 
ATOM   4962 D D    B VAL A 1 306 ? 13.22911  -11.66411 -20.29167 0.030 12.18277  ?  387 VAL A D    1 
ATOM   4963 H HA   . VAL A 1 306 ? 13.06579  -12.76798 -17.57926 1.000 12.21168  ?  387 VAL A HA   1 
ATOM   4964 H HB   . VAL A 1 306 ? 14.91466  -10.62703 -18.60764 1.000 11.93476  ?  387 VAL A HB   1 
ATOM   4965 H HG11 . VAL A 1 306 ? 14.71799  -12.25397 -16.06315 1.000 14.68555  ?  387 VAL A HG11 1 
ATOM   4966 H HG12 . VAL A 1 306 ? 16.16560  -11.32185 -16.53441 1.000 14.68555  ?  387 VAL A HG12 1 
ATOM   4967 H HG13 . VAL A 1 306 ? 14.61964  -10.48016 -16.23761 1.000 14.68555  ?  387 VAL A HG13 1 
ATOM   4968 H HG21 . VAL A 1 306 ? 16.60753  -12.41285 -18.54053 1.000 15.86136  ?  387 VAL A HG21 1 
ATOM   4969 H HG22 . VAL A 1 306 ? 15.32917  -13.59332 -18.14204 1.000 15.86136  ?  387 VAL A HG22 1 
ATOM   4970 H HG23 . VAL A 1 306 ? 15.31419  -12.76035 -19.72078 1.000 15.86136  ?  387 VAL A HG23 1 
ATOM   4971 N N    . LYS A 1 307 ? 12.32626  -9.64966  -18.28985 1.000 10.58443  ?  388 LYS A N    1 
ATOM   4972 C CA   . LYS A 1 307 ? 11.38279  -8.57965  -17.95071 1.000 11.37806  ?  388 LYS A CA   1 
ATOM   4973 C C    . LYS A 1 307 ? 9.97134   -8.95239  -18.38830 1.000 12.98119  ?  388 LYS A C    1 
ATOM   4974 O O    . LYS A 1 307 ? 9.76704   -9.27288  -19.56775 1.000 13.99511  ?  388 LYS A O    1 
ATOM   4975 C CB   . LYS A 1 307 ? 11.83127  -7.30046  -18.64652 1.000 13.65451  ?  388 LYS A CB   1 
ATOM   4976 C CG   . LYS A 1 307 ? 10.80770  -6.15251  -18.67168 1.000 14.64533  ?  388 LYS A CG   1 
ATOM   4977 C CD   . LYS A 1 307 ? 10.60593  -5.48127  -17.35865 1.000 16.61563  ?  388 LYS A CD   1 
ATOM   4978 C CE   . LYS A 1 307 ? 9.46052   -4.45172  -17.48016 1.000 18.48032  ?  388 LYS A CE   1 
ATOM   4979 N NZ   . LYS A 1 307 ? 9.27603   -3.59975  -16.23223 1.000 19.12622  ?  388 LYS A NZ   1 
ATOM   4980 H H    A LYS A 1 307 ? 12.96902  -9.41835  -19.04732 0.930 12.70131  ?  388 LYS A H    1 
ATOM   4981 D D    B LYS A 1 307 ? 12.96860  -9.41746  -19.04740 0.070 12.70131  ?  388 LYS A D    1 
ATOM   4982 H HA   . LYS A 1 307 ? 11.36450  -8.42465  -16.87194 1.000 13.65367  ?  388 LYS A HA   1 
ATOM   4983 H HB2  . LYS A 1 307 ? 12.71971  -6.92861  -18.13614 1.000 16.38541  ?  388 LYS A HB2  1 
ATOM   4984 H HB3  . LYS A 1 307 ? 12.06996  -7.54184  -19.68232 1.000 16.38541  ?  388 LYS A HB3  1 
ATOM   4985 H HG2  . LYS A 1 307 ? 11.14903  -5.39633  -19.37863 1.000 17.57439  ?  388 LYS A HG2  1 
ATOM   4986 H HG3  . LYS A 1 307 ? 9.84410   -6.55133  -18.98871 1.000 17.57439  ?  388 LYS A HG3  1 
ATOM   4987 H HD2  . LYS A 1 307 ? 10.33774  -6.21952  -16.60290 1.000 19.93876  ?  388 LYS A HD2  1 
ATOM   4988 H HD3  . LYS A 1 307 ? 11.51772  -4.96126  -17.06481 1.000 19.93876  ?  388 LYS A HD3  1 
ATOM   4989 H HE2  . LYS A 1 307 ? 9.67590   -3.78161  -18.31243 1.000 22.17639  ?  388 LYS A HE2  1 
ATOM   4990 H HE3  . LYS A 1 307 ? 8.52655   -4.98352  -17.66180 1.000 22.17639  ?  388 LYS A HE3  1 
ATOM   4991 H HZ1  A LYS A 1 307 ? 8.76432   -2.72623  -16.47034 0.320 22.95147  ?  388 LYS A HZ1  1 
ATOM   4992 D DZ1  B LYS A 1 307 ? 8.69113   -2.76846  -16.45233 0.680 22.95147  ?  388 LYS A DZ1  1 
ATOM   4993 H HZ2  A LYS A 1 307 ? 8.73163   -4.12619  -15.51942 0.120 22.95147  ?  388 LYS A HZ2  1 
ATOM   4994 D DZ2  B LYS A 1 307 ? 8.80695   -4.15515  -15.48852 0.880 22.95147  ?  388 LYS A DZ2  1 
ATOM   4995 H HZ3  A LYS A 1 307 ? 10.20282  -3.34961  -15.83210 0.000 22.95147  ?  388 LYS A HZ3  1 
ATOM   4996 D DZ3  B LYS A 1 307 ? 10.20069  -3.27842  -15.88102 1.000 22.95147  ?  388 LYS A DZ3  1 
ATOM   4997 N N    . PRO A 1 308 ? 8.97818   -8.94586  -17.49342 1.000 12.47565  ?  389 PRO A N    1 
ATOM   4998 C CA   . PRO A 1 308 ? 7.62211   -9.33139  -17.92265 1.000 13.75302  ?  389 PRO A CA   1 
ATOM   4999 C C    . PRO A 1 308 ? 6.93224   -8.16256  -18.61781 1.000 13.68648  ?  389 PRO A C    1 
ATOM   5000 O O    . PRO A 1 308 ? 6.65477   -7.14747  -17.99952 1.000 15.74205  ?  389 PRO A O    1 
ATOM   5001 C CB   . PRO A 1 308 ? 6.91083   -9.68893  -16.60948 1.000 16.63169  ?  389 PRO A CB   1 
ATOM   5002 C CG   . PRO A 1 308 ? 7.98071   -9.72400  -15.54923 1.000 19.14462  ?  389 PRO A CG   1 
ATOM   5003 C CD   . PRO A 1 308 ? 9.07829   -8.84797  -16.03017 1.000 14.43075  ?  389 PRO A CD   1 
ATOM   5004 H HA   . PRO A 1 308 ? 7.65801   -10.20001 -18.58016 1.000 16.50363  ?  389 PRO A HA   1 
ATOM   5005 H HB2  . PRO A 1 308 ? 6.16469   -8.92851  -16.37896 1.000 19.95802  ?  389 PRO A HB2  1 
ATOM   5006 H HB3  . PRO A 1 308 ? 6.43231   -10.66347 -16.70639 1.000 19.95802  ?  389 PRO A HB3  1 
ATOM   5007 H HG2  . PRO A 1 308 ? 7.57522   -9.34976  -14.60922 1.000 22.97355  ?  389 PRO A HG2  1 
ATOM   5008 H HG3  . PRO A 1 308 ? 8.33449   -10.74706 -15.42160 1.000 22.97355  ?  389 PRO A HG3  1 
ATOM   5009 H HD2  . PRO A 1 308 ? 8.92670   -7.82044  -15.69957 1.000 17.31691  ?  389 PRO A HD2  1 
ATOM   5010 H HD3  . PRO A 1 308 ? 10.04506  -9.21252  -15.68295 1.000 17.31691  ?  389 PRO A HD3  1 
ATOM   5011 N N    . GLY A 1 309 ? 6.61103   -8.35344  -19.89245 1.000 14.33852  ?  390 GLY A N    1 
ATOM   5012 C CA   . GLY A 1 309 ? 6.02949   -7.27898  -20.68318 1.000 14.55597  ?  390 GLY A CA   1 
ATOM   5013 C C    . GLY A 1 309 ? 4.65006   -6.92420  -20.15800 1.000 15.70812  ?  390 GLY A C    1 
ATOM   5014 O O    . GLY A 1 309 ? 3.82158   -7.80580  -19.87594 1.000 16.79012  ?  390 GLY A O    1 
ATOM   5015 H H    A GLY A 1 309 ? 6.73922   -9.22877  -20.40017 1.000 17.20623  ?  390 GLY A H    1 
ATOM   5016 D D    B GLY A 1 309 ? 6.73830   -9.22775  -20.40214 0.000 17.20623  ?  390 GLY A D    1 
ATOM   5017 H HA2  . GLY A 1 309 ? 6.66506   -6.39501  -20.63063 1.000 17.46716  ?  390 GLY A HA2  1 
ATOM   5018 H HA3  . GLY A 1 309 ? 5.94122   -7.59124  -21.72376 1.000 17.46716  ?  390 GLY A HA3  1 
ATOM   5019 N N    . GLY A 1 310 ? 4.41344   -5.61828  -20.00101 1.000 14.08211  ?  391 GLY A N    1 
ATOM   5020 C CA   . GLY A 1 310 ? 3.19655   -5.09652  -19.41384 1.000 14.87607  ?  391 GLY A CA   1 
ATOM   5021 C C    . GLY A 1 310 ? 3.41983   -4.46470  -18.07054 1.000 17.29281  ?  391 GLY A C    1 
ATOM   5022 O O    . GLY A 1 310 ? 2.64020   -3.59996  -17.67107 1.000 18.89420  ?  391 GLY A O    1 
ATOM   5023 H H    A GLY A 1 310 ? 5.06912   -4.88901  -20.28147 0.000 16.89854  ?  391 GLY A H    1 
ATOM   5024 D D    B GLY A 1 310 ? 5.07076   -4.89081  -20.28230 1.000 16.89854  ?  391 GLY A D    1 
ATOM   5025 H HA2  . GLY A 1 310 ? 2.77230   -4.34426  -20.07883 1.000 17.85128  ?  391 GLY A HA2  1 
ATOM   5026 H HA3  . GLY A 1 310 ? 2.47996   -5.90910  -19.29421 1.000 17.85128  ?  391 GLY A HA3  1 
ATOM   5027 N N    . GLU A 1 311 ? 4.45181   -4.87314  -17.33891 1.000 14.21782  ?  392 GLU A N    1 
ATOM   5028 C CA   . GLU A 1 311 ? 4.80304   -4.20464  -16.10419 1.000 15.58415  ?  392 GLU A CA   1 
ATOM   5029 C C    . GLU A 1 311 ? 5.64969   -2.99182  -16.42127 1.000 16.09688  ?  392 GLU A C    1 
ATOM   5030 O O    . GLU A 1 311 ? 6.62644   -3.08522  -17.16559 1.000 16.70175  ?  392 GLU A O    1 
ATOM   5031 C CB   . GLU A 1 311 ? 5.55965   -5.17809  -15.20202 1.000 17.42638  ?  392 GLU A CB   1 
ATOM   5032 C CG   . GLU A 1 311 ? 4.67708   -6.33208  -14.73098 1.000 16.53972  ?  392 GLU A CG   1 
ATOM   5033 C CD   . GLU A 1 311 ? 5.38426   -7.33704  -13.83006 1.000 17.47789  ?  392 GLU A CD   1 
ATOM   5034 O OE1  . GLU A 1 311 ? 6.57289   -7.09185  -13.47824 1.000 21.69183  ?  392 GLU A OE1  1 
ATOM   5035 O OE2  . GLU A 1 311 ? 4.76704   -8.38240  -13.51679 1.000 19.38404  -1 392 GLU A OE2  1 
ATOM   5036 H H    A GLU A 1 311 ? 5.05597   -5.65931  -17.57835 0.400 17.06138  ?  392 GLU A H    1 
ATOM   5037 D D    B GLU A 1 311 ? 5.05617   -5.65925  -17.57804 0.600 17.06138  ?  392 GLU A D    1 
ATOM   5038 H HA   . GLU A 1 311 ? 3.91183   -3.86916  -15.57382 1.000 18.70098  ?  392 GLU A HA   1 
ATOM   5039 H HB2  . GLU A 1 311 ? 6.40104   -5.59661  -15.75429 1.000 20.91165  ?  392 GLU A HB2  1 
ATOM   5040 H HB3  . GLU A 1 311 ? 5.91956   -4.64400  -14.32264 1.000 20.91165  ?  392 GLU A HB3  1 
ATOM   5041 H HG2  . GLU A 1 311 ? 3.83691   -5.92174  -14.17077 1.000 19.84766  ?  392 GLU A HG2  1 
ATOM   5042 H HG3  . GLU A 1 311 ? 4.31394   -6.87215  -15.60537 1.000 19.84766  ?  392 GLU A HG3  1 
ATOM   5043 N N    . CYS A 1 312 ? 5.23629   -1.83235  -15.92349 1.000 15.57275  ?  393 CYS A N    1 
ATOM   5044 C CA   . CYS A 1 312 ? 5.80145   -0.56314  -16.35463 1.000 15.08708  ?  393 CYS A CA   1 
ATOM   5045 C C    . CYS A 1 312 ? 7.26893   -0.43566  -15.92572 1.000 15.31425  ?  393 CYS A C    1 
ATOM   5046 O O    . CYS A 1 312 ? 7.68580   -0.95115  -14.87253 1.000 18.19001  ?  393 CYS A O    1 
ATOM   5047 C CB   . CYS A 1 312 ? 4.98250   0.55640   -15.71552 1.000 17.80472  ?  393 CYS A CB   1 
ATOM   5048 S SG   . CYS A 1 312 ? 5.31569   2.16083   -16.40366 1.000 17.64898  ?  393 CYS A SG   1 
ATOM   5049 H H    A CYS A 1 312 ? 4.50740   -1.73822  -15.21620 0.080 18.68730  ?  393 CYS A H    1 
ATOM   5050 D D    B CYS A 1 312 ? 4.50756   -1.73677  -15.21623 0.920 18.68730  ?  393 CYS A D    1 
ATOM   5051 H HA   . CYS A 1 312 ? 5.77258   -0.48028  -17.44110 1.000 18.10450  ?  393 CYS A HA   1 
ATOM   5052 H HB2  . CYS A 1 312 ? 3.92337   0.34394   -15.86112 1.000 21.36566  ?  393 CYS A HB2  1 
ATOM   5053 H HB3  . CYS A 1 312 ? 5.21193   0.59552   -14.65066 1.000 21.36566  ?  393 CYS A HB3  1 
ATOM   5054 H HG   A CYS A 1 312 ? 6.51581   2.16613   -16.90334 0.300 21.17877  ?  393 CYS A HG   1 
ATOM   5055 D DG   B CYS A 1 312 ? 6.55584   2.20603   -16.79091 0.700 21.17877  ?  393 CYS A DG   1 
ATOM   5056 N N    . ASP A 1 313 ? 8.04508   0.29041   -16.72107 1.000 14.96646  ?  394 ASP A N    1 
ATOM   5057 C CA   . ASP A 1 313 ? 9.44306   0.56386   -16.40675 1.000 15.70906  ?  394 ASP A CA   1 
ATOM   5058 C C    . ASP A 1 313 ? 9.63560   1.79476   -15.52762 1.000 18.90328  ?  394 ASP A C    1 
ATOM   5059 O O    . ASP A 1 313 ? 10.72046  1.97795   -14.97011 1.000 18.79112  ?  394 ASP A O    1 
ATOM   5060 C CB   . ASP A 1 313 ? 10.21877  0.83235   -17.70834 1.000 17.11270  ?  394 ASP A CB   1 
ATOM   5061 C CG   . ASP A 1 313 ? 10.28245  -0.36151  -18.62497 1.000 17.09220  ?  394 ASP A CG   1 
ATOM   5062 O OD1  . ASP A 1 313 ? 10.36396  -1.51571  -18.12998 1.000 20.19513  ?  394 ASP A OD1  1 
ATOM   5063 O OD2  . ASP A 1 313 ? 10.29506  -0.12310  -19.85494 1.000 15.93917  -1 394 ASP A OD2  1 
ATOM   5064 H H    A ASP A 1 313 ? 7.73368   0.70744   -17.59829 0.400 17.95975  ?  394 ASP A H    1 
ATOM   5065 D D    B ASP A 1 313 ? 7.73375   0.70747   -17.59830 0.600 17.95975  ?  394 ASP A D    1 
ATOM   5066 H HA   . ASP A 1 313 ? 9.84872   -0.30893  -15.89510 1.000 18.85087  ?  394 ASP A HA   1 
ATOM   5067 H HB2  . ASP A 1 313 ? 9.72980   1.64266   -18.24908 1.000 20.53525  ?  394 ASP A HB2  1 
ATOM   5068 H HB3  . ASP A 1 313 ? 11.24101  1.11530   -17.45723 1.000 20.53525  ?  394 ASP A HB3  1 
ATOM   5069 N N    . GLY A 1 314 ? 8.63803   2.68182   -15.44584 1.000 18.46739  ?  395 GLY A N    1 
ATOM   5070 C CA   . GLY A 1 314 ? 8.80897   3.94225   -14.74891 1.000 19.68804  ?  395 GLY A CA   1 
ATOM   5071 C C    . GLY A 1 314 ? 7.72431   4.92320   -15.14120 1.000 21.50878  ?  395 GLY A C    1 
ATOM   5072 O O    . GLY A 1 314 ? 7.15655   4.84264   -16.23143 1.000 17.89563  ?  395 GLY A O    1 
ATOM   5073 H H    A GLY A 1 314 ? 7.71157   2.54909   -15.85138 0.900 22.16086  ?  395 GLY A H    1 
ATOM   5074 D D    B GLY A 1 314 ? 7.71142   2.54958   -15.85119 0.100 22.16086  ?  395 GLY A D    1 
ATOM   5075 H HA2  . GLY A 1 314 ? 8.76089   3.77683   -13.67261 1.000 23.62565  ?  395 GLY A HA2  1 
ATOM   5076 H HA3  . GLY A 1 314 ? 9.77893   4.37211   -14.99890 1.000 23.62565  ?  395 GLY A HA3  1 
ATOM   5077 N N    . THR A 1 315 ? 7.42916   5.85889   -14.23365 1.000 20.95448  ?  396 THR A N    1 
ATOM   5078 C CA   . THR A 1 315 ? 6.33436   6.79333   -14.46988 1.000 21.62774  ?  396 THR A CA   1 
ATOM   5079 C C    . THR A 1 315 ? 6.77283   7.97424   -15.33679 1.000 20.22863  ?  396 THR A C    1 
ATOM   5080 O O    . THR A 1 315 ? 7.92888   8.40513   -15.30755 1.000 23.29260  ?  396 THR A O    1 
ATOM   5081 C CB   . THR A 1 315 ? 5.75261   7.27253   -13.13234 1.000 22.34234  ?  396 THR A CB   1 
ATOM   5082 O OG1  . THR A 1 315 ? 4.55312   8.02152   -13.40667 1.000 25.84755  ?  396 THR A OG1  1 
ATOM   5083 C CG2  . THR A 1 315 ? 6.74037   8.10719   -12.36373 1.000 24.63573  ?  396 THR A CG2  1 
ATOM   5084 H H    A THR A 1 315 ? 7.91958   5.98878   -13.34876 0.080 25.14537  ?  396 THR A H    1 
ATOM   5085 D D    B THR A 1 315 ? 7.91923   5.98921   -13.34864 0.920 25.14537  ?  396 THR A D    1 
ATOM   5086 H HA   . THR A 1 315 ? 5.53996   6.28873   -15.01981 1.000 25.95329  ?  396 THR A HA   1 
ATOM   5087 H HB   . THR A 1 315 ? 5.51867   6.41882   -12.49628 1.000 26.81081  ?  396 THR A HB   1 
ATOM   5088 H HG1  A THR A 1 315 ? 3.92908   7.47547   -13.92899 0.220 31.01706  ?  396 THR A HG1  1 
ATOM   5089 D DG1  B THR A 1 315 ? 3.98259   7.52439   -14.02937 0.780 31.01706  ?  396 THR A DG1  1 
ATOM   5090 H HG21 . THR A 1 315 ? 7.43525   7.46189   -11.82631 1.000 29.56287  ?  396 THR A HG21 1 
ATOM   5091 H HG22 . THR A 1 315 ? 7.30386   8.74198   -13.04756 1.000 29.56287  ?  396 THR A HG22 1 
ATOM   5092 H HG23 . THR A 1 315 ? 6.21634   8.73824   -11.64590 1.000 29.56287  ?  396 THR A HG23 1 
ATOM   5093 N N    . SER A 1 316 ? 5.81656   8.52131   -16.09959 1.000 20.69892  ?  397 SER A N    1 
ATOM   5094 C CA   . SER A 1 316 ? 6.02361   9.77630   -16.82433 1.000 21.65385  ?  397 SER A CA   1 
ATOM   5095 C C    . SER A 1 316 ? 5.56209   11.00569  -16.03826 1.000 24.58008  ?  397 SER A C    1 
ATOM   5096 O O    . SER A 1 316 ? 5.67686   12.13066  -16.54335 1.000 26.89910  ?  397 SER A O    1 
ATOM   5097 C CB   . SER A 1 316 ? 5.27343   9.72275   -18.15557 1.000 26.22651  ?  397 SER A CB   1 
ATOM   5098 O OG   . SER A 1 316 ? 3.89442   9.53449   -17.92684 1.000 21.55640  ?  397 SER A OG   1 
ATOM   5099 H H    A SER A 1 316 ? 4.88999   8.11616   -16.23274 0.000 24.83870  ?  397 SER A H    1 
ATOM   5100 D D    B SER A 1 316 ? 4.89031   8.11520   -16.23199 1.000 24.83870  ?  397 SER A D    1 
ATOM   5101 H HA   . SER A 1 316 ? 7.08842   9.89263   -17.02621 1.000 25.98462  ?  397 SER A HA   1 
ATOM   5102 H HB2  . SER A 1 316 ? 5.42324   10.66128  -18.68925 1.000 31.47181  ?  397 SER A HB2  1 
ATOM   5103 H HB3  . SER A 1 316 ? 5.65498   8.89163   -18.74865 1.000 31.47181  ?  397 SER A HB3  1 
ATOM   5104 H HG   A SER A 1 316 ? 3.50918   10.33880  -17.52055 0.220 25.86768  ?  397 SER A HG   1 
ATOM   5105 D DG   B SER A 1 316 ? 3.50962   10.33801  -17.51857 0.780 25.86768  ?  397 SER A DG   1 
ATOM   5106 N N    . ASN A 1 317 ? 5.05977   10.80451  -14.82948 1.000 20.22572  ?  398 ASN A N    1 
ATOM   5107 C CA   . ASN A 1 317 ? 4.51365   11.88347  -13.99341 1.000 23.76531  ?  398 ASN A CA   1 
ATOM   5108 C C    . ASN A 1 317 ? 5.66565   12.58663  -13.28573 1.000 25.32849  ?  398 ASN A C    1 
ATOM   5109 O O    . ASN A 1 317 ? 6.31569   12.00608  -12.40600 1.000 24.76937  ?  398 ASN A O    1 
ATOM   5110 C CB   . ASN A 1 317 ? 3.52687   11.26099  -13.00782 1.000 24.39408  ?  398 ASN A CB   1 
ATOM   5111 C CG   . ASN A 1 317 ? 3.12088   12.19977  -11.87421 1.000 36.84959  ?  398 ASN A CG   1 
ATOM   5112 O OD1  . ASN A 1 317 ? 3.20886   13.41560  -12.00011 1.000 29.82748  ?  398 ASN A OD1  1 
ATOM   5113 N ND2  . ASN A 1 317 ? 2.68888   11.62089  -10.75293 1.000 39.13642  ?  398 ASN A ND2  1 
ATOM   5114 H H    A ASN A 1 317 ? 5.01132   9.88887   -14.38267 0.000 24.27086  ?  398 ASN A H    1 
ATOM   5115 D D    B ASN A 1 317 ? 5.01155   9.88864   -14.38311 1.000 24.27086  ?  398 ASN A D    1 
ATOM   5116 H HA   . ASN A 1 317 ? 3.99872   12.63373  -14.59345 1.000 28.51837  ?  398 ASN A HA   1 
ATOM   5117 H HB2  . ASN A 1 317 ? 2.62237   10.97898  -13.54675 1.000 29.27289  ?  398 ASN A HB2  1 
ATOM   5118 H HB3  . ASN A 1 317 ? 3.98527   10.37856  -12.56141 1.000 29.27289  ?  398 ASN A HB3  1 
ATOM   5119 N N    . SER A 1 318 ? 5.92157   13.84385  -13.66375 1.000 28.15889  ?  399 SER A N    1 
ATOM   5120 C CA   . SER A 1 318 ? 7.08516   14.55652  -13.14101 1.000 28.82132  ?  399 SER A CA   1 
ATOM   5121 C C    . SER A 1 318 ? 6.93861   14.98421  -11.68417 1.000 26.91577  ?  399 SER A C    1 
ATOM   5122 O O    . SER A 1 318 ? 7.92414   15.44116  -11.09925 1.000 36.42302  ?  399 SER A O    1 
ATOM   5123 C CB   . SER A 1 318 ? 7.39955   15.76859  -14.00320 1.000 37.31176  ?  399 SER A CB   1 
ATOM   5124 O OG   . SER A 1 318 ? 6.25916   16.58853  -14.11928 1.000 33.30864  ?  399 SER A OG   1 
ATOM   5125 H H    A SER A 1 318 ? 5.35235   14.38223  -14.31684 0.180 33.79067  ?  399 SER A H    1 
ATOM   5126 D D    B SER A 1 318 ? 5.35295   14.38298  -14.31675 0.820 33.79067  ?  399 SER A D    1 
ATOM   5127 H HA   . SER A 1 318 ? 7.93720   13.87882  -13.19434 1.000 34.58558  ?  399 SER A HA   1 
ATOM   5128 H HB2  . SER A 1 318 ? 8.20497   16.33854  -13.54000 1.000 44.77412  ?  399 SER A HB2  1 
ATOM   5129 H HB3  . SER A 1 318 ? 7.70253   15.43371  -14.99524 1.000 44.77412  ?  399 SER A HB3  1 
ATOM   5130 N N    . SER A 1 319 ? 5.77019   14.81573  -11.08799 1.000 24.43290  ?  400 SER A N    1 
ATOM   5131 C CA   . SER A 1 319 ? 5.57273   15.06576  -9.67302  1.000 30.02157  ?  400 SER A CA   1 
ATOM   5132 C C    . SER A 1 319 ? 5.81440   13.84308  -8.79979  1.000 33.12927  ?  400 SER A C    1 
ATOM   5133 O O    . SER A 1 319 ? 5.77865   13.95253  -7.56995  1.000 35.32089  ?  400 SER A O    1 
ATOM   5134 C CB   . SER A 1 319 ? 4.13597   15.54832  -9.44782  1.000 34.47607  ?  400 SER A CB   1 
ATOM   5135 O OG   . SER A 1 319 ? 3.91188   16.77215  -10.14074 1.000 43.59222  ?  400 SER A OG   1 
ATOM   5136 H H    A SER A 1 319 ? 4.92657   14.50128  -11.56740 0.260 29.31949  ?  400 SER A H    1 
ATOM   5137 D D    B SER A 1 319 ? 4.92691   14.50124  -11.56798 0.740 29.31949  ?  400 SER A D    1 
ATOM   5138 H HA   . SER A 1 319 ? 6.27012   15.84046  -9.35430  1.000 36.02588  ?  400 SER A HA   1 
ATOM   5139 H HB2  . SER A 1 319 ? 3.44310   14.79425  -9.82118  1.000 41.37128  ?  400 SER A HB2  1 
ATOM   5140 H HB3  . SER A 1 319 ? 3.97528   15.70686  -8.38145  1.000 41.37128  ?  400 SER A HB3  1 
ATOM   5141 N N    . SER A 1 320 ? 6.05800   12.67540  -9.37644  1.000 28.69010  ?  401 SER A N    1 
ATOM   5142 C CA   . SER A 1 320 ? 6.31434   11.51110  -8.54423  1.000 28.78940  ?  401 SER A CA   1 
ATOM   5143 C C    . SER A 1 320 ? 7.72800   11.60421  -7.96374  1.000 27.83766  ?  401 SER A C    1 
ATOM   5144 O O    . SER A 1 320 ? 8.64753   12.11836  -8.62053  1.000 30.67676  ?  401 SER A O    1 
ATOM   5145 C CB   . SER A 1 320 ? 6.20635   10.23136  -9.36417  1.000 32.99821  ?  401 SER A CB   1 
ATOM   5146 O OG   . SER A 1 320 ? 6.86813   9.17734   -8.68573  1.000 28.50317  ?  401 SER A OG   1 
ATOM   5147 H H    A SER A 1 320 ? 6.08418   12.50766  -10.38221 0.080 34.42812  ?  401 SER A H    1 
ATOM   5148 D D    B SER A 1 320 ? 6.08464   12.50553  -10.38184 0.920 34.42812  ?  401 SER A D    1 
ATOM   5149 H HA   . SER A 1 320 ? 5.58446   11.46979  -7.73573  1.000 34.54728  ?  401 SER A HA   1 
ATOM   5150 H HB2  . SER A 1 320 ? 5.15526   9.97336   -9.49355  1.000 39.59786  ?  401 SER A HB2  1 
ATOM   5151 H HB3  . SER A 1 320 ? 6.67489   10.38505  -10.33625 1.000 39.59786  ?  401 SER A HB3  1 
ATOM   5152 H HG   A SER A 1 320 ? 6.24793   8.43344   -8.53620  0.000 34.20381  ?  401 SER A HG   1 
ATOM   5153 D DG   B SER A 1 320 ? 6.24325   8.44077   -8.52025  1.000 34.20381  ?  401 SER A DG   1 
ATOM   5154 N N    A PRO A 1 321 ? 7.91159   11.17898  -6.70862  0.650 27.89375  ?  402 PRO A N    1 
ATOM   5155 N N    B PRO A 1 321 ? 7.96113   11.06769  -6.78521  0.350 28.45910  ?  402 PRO A N    1 
ATOM   5156 C CA   A PRO A 1 321 ? 9.26704   11.09150  -6.14443  0.650 34.16339  ?  402 PRO A CA   1 
ATOM   5157 C CA   B PRO A 1 321 ? 9.34451   11.06649  -6.27514  0.350 34.39940  ?  402 PRO A CA   1 
ATOM   5158 C C    A PRO A 1 321 ? 10.08280  9.95280   -6.72566  0.650 38.69558  ?  402 PRO A C    1 
ATOM   5159 C C    B PRO A 1 321 ? 10.37529  10.43773  -7.21612  0.350 38.51574  ?  402 PRO A C    1 
ATOM   5160 O O    A PRO A 1 321 ? 11.29517  9.89773   -6.47908  0.650 35.81847  ?  402 PRO A O    1 
ATOM   5161 O O    B PRO A 1 321 ? 11.57838  10.67163  -7.07007  0.350 32.78916  ?  402 PRO A O    1 
ATOM   5162 C CB   A PRO A 1 321 ? 9.01090   10.87967  -4.64845  0.650 31.03912  ?  402 PRO A CB   1 
ATOM   5163 C CB   B PRO A 1 321 ? 9.24207   10.28606  -4.95313  0.350 33.16235  ?  402 PRO A CB   1 
ATOM   5164 C CG   A PRO A 1 321 ? 7.66911   10.18313  -4.59357  0.650 34.81595  ?  402 PRO A CG   1 
ATOM   5165 C CG   B PRO A 1 321 ? 7.80594   10.45440  -4.52510  0.350 33.68165  ?  402 PRO A CG   1 
ATOM   5166 C CD   A PRO A 1 321 ? 6.87172   10.75595  -5.75139  0.650 30.13097  ?  402 PRO A CD   1 
ATOM   5167 C CD   B PRO A 1 321 ? 6.99722   10.54527  -5.79988  0.350 30.79972  ?  402 PRO A CD   1 
ATOM   5168 H HA   A PRO A 1 321 ? 9.80050   12.03178  -6.28373  0.650 40.99607  ?  402 PRO A HA   1 
ATOM   5169 H HA   B PRO A 1 321 ? 9.64381   12.09645  -6.08099  0.350 41.27929  ?  402 PRO A HA   1 
ATOM   5170 H HB2  A PRO A 1 321 ? 9.79511   10.25603  -4.21927  0.650 37.24695  ?  402 PRO A HB2  1 
ATOM   5171 H HB2  B PRO A 1 321 ? 9.48078   9.23574   -5.12035  0.350 39.79482  ?  402 PRO A HB2  1 
ATOM   5172 H HB3  A PRO A 1 321 ? 8.97599   11.84061  -4.13515  0.650 37.24695  ?  402 PRO A HB3  1 
ATOM   5173 H HB3  B PRO A 1 321 ? 9.92330   10.71034  -4.21555  0.350 39.79482  ?  402 PRO A HB3  1 
ATOM   5174 H HG2  A PRO A 1 321 ? 7.80530   9.10800   -4.71034  0.650 41.77914  ?  402 PRO A HG2  1 
ATOM   5175 H HG2  B PRO A 1 321 ? 7.49639   9.59306   -3.93317  0.350 40.41798  ?  402 PRO A HG2  1 
ATOM   5176 H HG3  A PRO A 1 321 ? 7.18040   10.39592  -3.64279  0.650 41.77914  ?  402 PRO A HG3  1 
ATOM   5177 H HG3  B PRO A 1 321 ? 7.70294   11.36682  -3.93776  0.350 40.41798  ?  402 PRO A HG3  1 
ATOM   5178 H HD2  A PRO A 1 321 ? 6.22686   9.99523   -6.19132  0.650 36.15716  ?  402 PRO A HD2  1 
ATOM   5179 H HD2  B PRO A 1 321 ? 6.63392   9.56186   -6.09824  0.350 36.95967  ?  402 PRO A HD2  1 
ATOM   5180 H HD3  A PRO A 1 321 ? 6.27485   11.60814  -5.42640  0.650 36.15716  ?  402 PRO A HD3  1 
ATOM   5181 H HD3  B PRO A 1 321 ? 6.15890   11.23116  -5.67788  0.350 36.95967  ?  402 PRO A HD3  1 
ATOM   5182 N N    A ARG A 1 322 ? 9.45711   9.04153   -7.47257  0.650 23.95394  ?  403 ARG A N    1 
ATOM   5183 N N    B ARG A 1 322 ? 9.91567   9.67015   -8.21428  0.350 31.16465  ?  403 ARG A N    1 
ATOM   5184 C CA   A ARG A 1 322 ? 10.18331  8.00873   -8.20598  0.650 35.74822  ?  403 ARG A CA   1 
ATOM   5185 C CA   B ARG A 1 322 ? 10.78366  8.76832   -8.97125  0.350 32.49416  ?  403 ARG A CA   1 
ATOM   5186 C C    A ARG A 1 322 ? 10.39778  8.37773   -9.66991  0.650 31.20887  ?  403 ARG A C    1 
ATOM   5187 C C    B ARG A 1 322 ? 10.81271  9.07141   -10.47045 0.350 31.80836  ?  403 ARG A C    1 
ATOM   5188 O O    A ARG A 1 322 ? 10.80874  7.52517   -10.46245 0.650 29.67441  ?  403 ARG A O    1 
ATOM   5189 O O    B ARG A 1 322 ? 11.17029  8.20053   -11.27082 0.350 28.93680  ?  403 ARG A O    1 
ATOM   5190 C CB   A ARG A 1 322 ? 9.44047   6.67769   -8.11140  0.650 36.10053  ?  403 ARG A CB   1 
ATOM   5191 C CB   B ARG A 1 322 ? 10.35608  7.31619   -8.73375  0.350 35.00874  ?  403 ARG A CB   1 
ATOM   5192 C CG   A ARG A 1 322 ? 9.35289   6.10016   -6.69714  0.650 48.51778  ?  403 ARG A CG   1 
ATOM   5193 C CG   B ARG A 1 322 ? 10.43247  6.86671   -7.27943  0.350 33.45612  ?  403 ARG A CG   1 
ATOM   5194 C CD   A ARG A 1 322 ? 10.65743  5.41502   -6.27569  0.650 49.66632  ?  403 ARG A CD   1 
ATOM   5195 C CD   B ARG A 1 322 ? 9.13198   6.19807   -6.81073  0.350 46.92430  ?  403 ARG A CD   1 
ATOM   5196 N NE   A ARG A 1 322 ? 11.56038  6.32868   -5.59445  0.650 54.46519  ?  403 ARG A NE   1 
ATOM   5197 N NE   B ARG A 1 322 ? 8.88470   4.90998   -7.44859  0.350 47.70065  ?  403 ARG A NE   1 
ATOM   5198 C CZ   A ARG A 1 322 ? 11.77865  6.32398   -4.28405  0.650 57.40163  ?  403 ARG A CZ   1 
ATOM   5199 C CZ   B ARG A 1 322 ? 7.83202   4.13687   -7.20147  0.350 37.51530  ?  403 ARG A CZ   1 
ATOM   5200 N NH1  A ARG A 1 322 ? 11.23614  5.40668   -3.49632  0.650 50.13683  ?  403 ARG A NH1  1 
ATOM   5201 N NH1  B ARG A 1 322 ? 6.89690   4.49844   -6.33610  0.350 44.61757  ?  403 ARG A NH1  1 
ATOM   5202 N NH2  A ARG A 1 322 ? 12.56057  7.26072   -3.75501  0.650 54.40931  ?  403 ARG A NH2  1 
ATOM   5203 N NH2  B ARG A 1 322 ? 7.71273   2.97890   -7.84415  0.350 31.74906  ?  403 ARG A NH2  1 
ATOM   5204 H HA   A ARG A 1 322 ? 11.16256  7.88011   -7.74485  0.650 42.89787  ?  403 ARG A HA   1 
ATOM   5205 H HA   B ARG A 1 322 ? 11.80321  8.90172   -8.60957  0.350 38.99299  ?  403 ARG A HA   1 
ATOM   5206 H HB2  A ARG A 1 322 ? 8.42200   6.82198   -8.47196  0.650 43.32063  ?  403 ARG A HB2  1 
ATOM   5207 H HB2  B ARG A 1 322 ? 9.32275   7.20031   -9.06070  0.350 42.01049  ?  403 ARG A HB2  1 
ATOM   5208 H HB3  A ARG A 1 322 ? 9.95643   5.94699   -8.73426  0.650 43.32063  ?  403 ARG A HB3  1 
ATOM   5209 H HB3  B ARG A 1 322 ? 11.00658  6.66288   -9.31525  0.350 42.01049  ?  403 ARG A HB3  1 
ATOM   5210 H HG2  A ARG A 1 322 ? 9.14862   6.90607   -5.99224  0.650 58.22134  ?  403 ARG A HG2  1 
ATOM   5211 H HG2  B ARG A 1 322 ? 11.24324  6.14657   -7.16917  0.350 40.14734  ?  403 ARG A HG2  1 
ATOM   5212 H HG3  A ARG A 1 322 ? 8.55283   5.36081   -6.66017  0.650 58.22134  ?  403 ARG A HG3  1 
ATOM   5213 H HG3  B ARG A 1 322 ? 10.61566  7.73428   -6.64550  0.350 40.14734  ?  403 ARG A HG3  1 
ATOM   5214 H HD2  A ARG A 1 322 ? 10.42766  4.59444   -5.59602  0.650 59.59958  ?  403 ARG A HD2  1 
ATOM   5215 H HD2  B ARG A 1 322 ? 9.18732   6.03332   -5.73467  0.350 56.30915  ?  403 ARG A HD2  1 
ATOM   5216 H HD3  A ARG A 1 322 ? 11.16448  5.03400   -7.16216  0.650 59.59958  ?  403 ARG A HD3  1 
ATOM   5217 H HD3  B ARG A 1 322 ? 8.29331   6.85375   -7.04485  0.350 56.30915  ?  403 ARG A HD3  1 
ATOM   5218 N N    A TYR A 1 323 ? 10.14883  9.63215   -10.03565 0.650 25.45126  ?  404 TYR A N    1 
ATOM   5219 N N    B TYR A 1 323 ? 10.47337  10.29313  -10.86868 0.350 29.02188  ?  404 TYR A N    1 
ATOM   5220 C CA   A TYR A 1 323 ? 10.20405  10.05729  -11.43078 0.650 22.38414  ?  404 TYR A CA   1 
ATOM   5221 C CA   B TYR A 1 323 ? 10.39482  10.63397  -12.28243 0.350 25.62076  ?  404 TYR A CA   1 
ATOM   5222 C C    A TYR A 1 323 ? 11.60555  9.93682   -12.00962 0.650 27.64041  ?  404 TYR A C    1 
ATOM   5223 C C    B TYR A 1 323 ? 11.76251  10.60173  -12.95070 0.350 25.23235  ?  404 TYR A C    1 
ATOM   5224 O O    A TYR A 1 323 ? 12.57896  10.44617  -11.44565 0.650 23.02774  ?  404 TYR A O    1 
ATOM   5225 O O    B TYR A 1 323 ? 12.76362  11.07214  -12.39700 0.350 21.50880  ?  404 TYR A O    1 
ATOM   5226 C CB   A TYR A 1 323 ? 9.75938   11.51509  -11.50691 0.650 27.45744  ?  404 TYR A CB   1 
ATOM   5227 C CB   B TYR A 1 323 ? 9.80815   12.03366  -12.43606 0.350 25.29417  ?  404 TYR A CB   1 
ATOM   5228 C CG   A TYR A 1 323 ? 9.87155   12.15606  -12.86945 0.650 24.13674  ?  404 TYR A CG   1 
ATOM   5229 C CG   B TYR A 1 323 ? 9.83546   12.60896  -13.84398 0.350 21.58015  ?  404 TYR A CG   1 
ATOM   5230 C CD1  A TYR A 1 323 ? 9.20056   11.62027  -13.96323 0.650 23.64453  ?  404 TYR A CD1  1 
ATOM   5231 C CD1  B TYR A 1 323 ? 8.97364   12.13543  -14.82832 0.350 24.78733  ?  404 TYR A CD1  1 
ATOM   5232 C CD2  A TYR A 1 323 ? 10.59897  13.31977  -13.05095 0.650 25.34423  ?  404 TYR A CD2  1 
ATOM   5233 C CD2  B TYR A 1 323 ? 10.66587  13.67526  -14.16166 0.350 24.65480  ?  404 TYR A CD2  1 
ATOM   5234 C CE1  A TYR A 1 323 ? 9.27855   12.20689  -15.19249 0.650 25.69795  ?  404 TYR A CE1  1 
ATOM   5235 C CE1  B TYR A 1 323 ? 8.96506   12.68577  -16.10791 0.350 21.69454  ?  404 TYR A CE1  1 
ATOM   5236 C CE2  A TYR A 1 323 ? 10.68492  13.91860  -14.28666 0.650 24.52172  ?  404 TYR A CE2  1 
ATOM   5237 C CE2  B TYR A 1 323 ? 10.67214  14.22666  -15.43460 0.350 24.50139  ?  404 TYR A CE2  1 
ATOM   5238 C CZ   A TYR A 1 323 ? 10.01659  13.36057  -15.35269 0.650 24.88322  ?  404 TYR A CZ   1 
ATOM   5239 C CZ   B TYR A 1 323 ? 9.81499   13.72806  -16.40275 0.350 23.49200  ?  404 TYR A CZ   1 
ATOM   5240 O OH   A TYR A 1 323 ? 10.08661  13.95085  -16.58960 0.650 27.28956  ?  404 TYR A OH   1 
ATOM   5241 O OH   B TYR A 1 323 ? 9.82747   14.27993  -17.65852 0.350 31.39476  ?  404 TYR A OH   1 
ATOM   5242 H HA   A TYR A 1 323 ? 9.54779   9.41874   -12.02212 0.650 26.86097  ?  404 TYR A HA   1 
ATOM   5243 H HA   B TYR A 1 323 ? 9.75864   9.90267   -12.78100 0.350 30.74491  ?  404 TYR A HA   1 
ATOM   5244 H HB2  A TYR A 1 323 ? 8.71298   11.57091  -11.20685 0.650 32.94893  ?  404 TYR A HB2  1 
ATOM   5245 H HB2  B TYR A 1 323 ? 8.76575   12.00431  -12.11881 0.350 30.35300  ?  404 TYR A HB2  1 
ATOM   5246 H HB3  A TYR A 1 323 ? 10.37520  12.09803  -10.82204 0.650 32.94893  ?  404 TYR A HB3  1 
ATOM   5247 H HB3  B TYR A 1 323 ? 10.37305  12.71323  -11.79796 0.350 30.35300  ?  404 TYR A HB3  1 
ATOM   5248 H HD1  A TYR A 1 323 ? 8.60846   10.72581  -13.83766 0.650 28.37344  ?  404 TYR A HD1  1 
ATOM   5249 H HD1  B TYR A 1 323 ? 8.29821   11.32543  -14.59576 0.350 29.74480  ?  404 TYR A HD1  1 
ATOM   5250 H HD2  A TYR A 1 323 ? 11.10746  13.76500  -12.20856 0.650 30.41308  ?  404 TYR A HD2  1 
ATOM   5251 H HD2  B TYR A 1 323 ? 11.31879  14.08285  -13.40406 0.350 29.58576  ?  404 TYR A HD2  1 
ATOM   5252 H HE1  A TYR A 1 323 ? 8.76477   11.76983  -16.03594 0.650 30.83754  ?  404 TYR A HE1  1 
ATOM   5253 H HE1  B TYR A 1 323 ? 8.29704   12.29798  -16.86274 0.350 26.03344  ?  404 TYR A HE1  1 
ATOM   5254 H HE2  A TYR A 1 323 ? 11.27029  14.81654  -14.41872 0.650 29.42606  ?  404 TYR A HE2  1 
ATOM   5255 H HE2  B TYR A 1 323 ? 11.34180  15.04062  -15.67001 0.350 29.40167  ?  404 TYR A HE2  1 
ATOM   5256 N N    A ASP A 1 324 ? 11.70338  9.28304   -13.15976 0.650 23.23908  ?  405 ASP A N    1 
ATOM   5257 N N    B ASP A 1 324 ? 11.78812  10.06448  -14.16974 0.350 22.27614  ?  405 ASP A N    1 
ATOM   5258 C CA   A ASP A 1 324 ? 12.92837  9.25971   -13.94727 0.650 19.40991  ?  405 ASP A CA   1 
ATOM   5259 C CA   B ASP A 1 324 ? 12.94688  10.14199  -15.05441 0.350 23.26829  ?  405 ASP A CA   1 
ATOM   5260 C C    A ASP A 1 324 ? 12.58309  9.92412   -15.27155 0.650 21.46456  ?  405 ASP A C    1 
ATOM   5261 C C    B ASP A 1 324 ? 12.49176  10.70946  -16.39099 0.350 22.75552  ?  405 ASP A C    1 
ATOM   5262 O O    A ASP A 1 324 ? 11.70901  9.43522   -16.00083 0.650 19.66343  ?  405 ASP A O    1 
ATOM   5263 O O    B ASP A 1 324 ? 11.60515  10.14146  -17.03817 0.350 19.61873  ?  405 ASP A O    1 
ATOM   5264 C CB   A ASP A 1 324 ? 13.40037  7.81602   -14.16256 0.650 21.87765  ?  405 ASP A CB   1 
ATOM   5265 C CB   B ASP A 1 324 ? 13.58790  8.76423   -15.26207 0.350 27.01146  ?  405 ASP A CB   1 
ATOM   5266 C CG   A ASP A 1 324 ? 14.75220  7.73191   -14.82401 0.650 22.54122  ?  405 ASP A CG   1 
ATOM   5267 C CG   B ASP A 1 324 ? 14.84446  8.82639   -16.12651 0.350 24.90530  ?  405 ASP A CG   1 
ATOM   5268 O OD1  A ASP A 1 324 ? 14.97591  8.44701   -15.82769 0.650 25.29041  ?  405 ASP A OD1  1 
ATOM   5269 O OD1  B ASP A 1 324 ? 14.86369  9.56256   -17.13583 0.350 24.88256  ?  405 ASP A OD1  1 
ATOM   5270 O OD2  A ASP A 1 324 ? 15.60154  6.94623   -14.32671 0.650 21.13184  -1 405 ASP A OD2  1 
ATOM   5271 O OD2  B ASP A 1 324 ? 15.81817  8.12557   -15.78140 0.350 29.34307  -1 405 ASP A OD2  1 
ATOM   5272 H HA   A ASP A 1 324 ? 13.73756  9.80196   -13.45812 0.650 23.29189  ?  405 ASP A HA   1 
ATOM   5273 H HA   B ASP A 1 324 ? 13.69084  10.80741  -14.61642 0.350 27.92195  ?  405 ASP A HA   1 
ATOM   5274 H HB2  A ASP A 1 324 ? 13.46769  7.31732   -13.19567 0.650 26.25318  ?  405 ASP A HB2  1 
ATOM   5275 H HB2  B ASP A 1 324 ? 13.86507  8.35082   -14.29235 0.350 32.41375  ?  405 ASP A HB2  1 
ATOM   5276 H HB3  A ASP A 1 324 ? 12.68198  7.29957   -14.79919 0.650 26.25318  ?  405 ASP A HB3  1 
ATOM   5277 H HB3  B ASP A 1 324 ? 12.87046  8.10861   -15.75556 0.350 32.41375  ?  405 ASP A HB3  1 
ATOM   5278 N N    A SER A 1 325 ? 13.26199  11.03272  -15.57985 0.650 23.34554  ?  406 SER A N    1 
ATOM   5279 N N    B SER A 1 325 ? 13.11510  11.81443  -16.80821 0.350 24.87432  ?  406 SER A N    1 
ATOM   5280 C CA   A SER A 1 325 ? 12.90557  11.79310  -16.77358 0.650 23.65151  ?  406 SER A CA   1 
ATOM   5281 C CA   B SER A 1 325 ? 12.75998  12.47474  -18.06070 0.350 23.85516  ?  406 SER A CA   1 
ATOM   5282 C C    A SER A 1 325 ? 13.12246  10.99146  -18.04682 0.650 22.80777  ?  406 SER A C    1 
ATOM   5283 C C    B SER A 1 325 ? 12.84333  11.53938  -19.26503 0.350 21.74994  ?  406 SER A C    1 
ATOM   5284 O O    A SER A 1 325 ? 12.59342  11.36798  -19.09923 0.650 22.01883  ?  406 SER A O    1 
ATOM   5285 O O    B SER A 1 325 ? 12.25138  11.83792  -20.30871 0.350 22.19420  ?  406 SER A O    1 
ATOM   5286 C CB   A SER A 1 325 ? 13.69730  13.10691  -16.84549 0.650 22.74401  ?  406 SER A CB   1 
ATOM   5287 C CB   B SER A 1 325 ? 13.66354  13.69740  -18.28354 0.350 25.69930  ?  406 SER A CB   1 
ATOM   5288 O OG   A SER A 1 325 ? 15.05614  12.87003  -17.13669 0.650 26.54000  ?  406 SER A OG   1 
ATOM   5289 O OG   B SER A 1 325 ? 14.75163  13.41078  -19.15684 0.350 30.76503  ?  406 SER A OG   1 
ATOM   5290 H HA   A SER A 1 325 ? 11.84919  12.05308  -16.70601 0.650 28.38181  ?  406 SER A HA   1 
ATOM   5291 H HA   B SER A 1 325 ? 11.72922  12.82124  -17.98604 0.350 28.62620  ?  406 SER A HA   1 
ATOM   5292 H HB2  A SER A 1 325 ? 13.27213  13.73263  -17.63022 0.650 27.29281  ?  406 SER A HB2  1 
ATOM   5293 H HB2  B SER A 1 325 ? 13.06628  14.49712  -18.72151 0.350 30.83915  ?  406 SER A HB2  1 
ATOM   5294 H HB3  A SER A 1 325 ? 13.62588  13.61503  -15.88382 0.650 27.29281  ?  406 SER A HB3  1 
ATOM   5295 H HB3  B SER A 1 325 ? 14.06363  14.01535  -17.32076 0.350 30.83915  ?  406 SER A HB3  1 
ATOM   5296 N N    A THR A 1 326 ? 13.87739  9.89006   -17.98848 0.650 20.05218  ?  407 THR A N    1 
ATOM   5297 N N    B THR A 1 326 ? 13.57006  10.42530  -19.15293 0.350 21.80206  ?  407 THR A N    1 
ATOM   5298 C CA   A THR A 1 326 ? 13.95554  9.04903   -19.18039 0.650 18.02162  ?  407 THR A CA   1 
ATOM   5299 C CA   B THR A 1 326 ? 13.63130  9.47319   -20.26117 0.350 18.63873  ?  407 THR A CA   1 
ATOM   5300 C C    A THR A 1 326 ? 12.57839  8.61273   -19.63361 0.650 19.19000  ?  407 THR A C    1 
ATOM   5301 C C    B THR A 1 326 ? 12.24836  8.91539   -20.59387 0.350 20.84832  ?  407 THR A C    1 
ATOM   5302 O O    A THR A 1 326 ? 12.37143  8.33998   -20.81842 0.650 19.55718  ?  407 THR A O    1 
ATOM   5303 O O    B THR A 1 326 ? 11.98391  8.53388   -21.74508 0.350 16.93420  ?  407 THR A O    1 
ATOM   5304 C CB   A THR A 1 326 ? 14.81702  7.81589   -18.90057 0.650 18.96730  ?  407 THR A CB   1 
ATOM   5305 C CB   B THR A 1 326 ? 14.58108  8.33214   -19.88555 0.350 23.44290  ?  407 THR A CB   1 
ATOM   5306 O OG1  A THR A 1 326 ? 16.00140  8.21440   -18.20326 0.650 21.98474  ?  407 THR A OG1  1 
ATOM   5307 O OG1  B THR A 1 326 ? 15.86622  8.85512   -19.52875 0.350 21.27249  ?  407 THR A OG1  1 
ATOM   5308 C CG2  A THR A 1 326 ? 15.21589  7.09198   -20.21099 0.650 23.30014  ?  407 THR A CG2  1 
ATOM   5309 C CG2  B THR A 1 326 ? 14.74251  7.34002   -21.04144 0.350 26.02177  ?  407 THR A CG2  1 
ATOM   5310 H HA   A THR A 1 326 ? 14.42458  9.62103   -19.98097 0.650 21.62595  ?  407 THR A HA   1 
ATOM   5311 H HA   B THR A 1 326 ? 14.01438  9.97378   -21.15042 0.350 22.36648  ?  407 THR A HA   1 
ATOM   5312 H HB   A THR A 1 326 ? 14.24432  7.11354   -18.29492 0.650 22.76077  ?  407 THR A HB   1 
ATOM   5313 H HB   B THR A 1 326 ? 14.15992  7.79652   -19.03477 0.350 28.13148  ?  407 THR A HB   1 
ATOM   5314 H HG21 A THR A 1 326 ? 14.44862  7.24513   -20.96990 0.650 27.96017  ?  407 THR A HG21 1 
ATOM   5315 H HG21 B THR A 1 326 ? 14.61003  7.85281   -21.99412 0.350 31.22612  ?  407 THR A HG21 1 
ATOM   5316 H HG22 A THR A 1 326 ? 16.16276  7.48534   -20.58085 0.650 27.96017  ?  407 THR A HG22 1 
ATOM   5317 H HG22 B THR A 1 326 ? 15.73714  6.89496   -21.01457 0.350 31.22612  ?  407 THR A HG22 1 
ATOM   5318 H HG23 A THR A 1 326 ? 15.32421  6.02289   -20.02819 0.650 27.96017  ?  407 THR A HG23 1 
ATOM   5319 H HG23 B THR A 1 326 ? 13.99821  6.54793   -20.95957 0.350 31.22612  ?  407 THR A HG23 1 
ATOM   5320 N N    A CYS A 1 327 ? 11.62466  8.54069   -18.71234 0.650 17.19930  ?  408 CYS A N    1 
ATOM   5321 N N    B CYS A 1 327 ? 11.35220  8.85190   -19.61089 0.350 15.26556  ?  408 CYS A N    1 
ATOM   5322 C CA   A CYS A 1 327 ? 10.28179  8.04943   -19.00010 0.650 14.40457  ?  408 CYS A CA   1 
ATOM   5323 C CA   B CYS A 1 327 ? 10.03684  8.25308   -19.82598 0.350 18.73656  ?  408 CYS A CA   1 
ATOM   5324 C C    A CYS A 1 327 ? 9.36710   9.13037   -19.56990 0.650 18.31927  ?  408 CYS A C    1 
ATOM   5325 C C    B CYS A 1 327 ? 9.00975   9.24402   -20.36281 0.350 15.65433  ?  408 CYS A C    1 
ATOM   5326 O O    A CYS A 1 327 ? 8.18757   8.85168   -19.82570 0.650 18.99182  ?  408 CYS A O    1 
ATOM   5327 O O    B CYS A 1 327 ? 7.84937   8.86943   -20.54262 0.350 16.78248  ?  408 CYS A O    1 
ATOM   5328 C CB   A CYS A 1 327 ? 9.70931   7.44969   -17.72361 0.650 15.82787  ?  408 CYS A CB   1 
ATOM   5329 C CB   B CYS A 1 327 ? 9.50877   7.63881   -18.52697 0.350 16.80791  ?  408 CYS A CB   1 
ATOM   5330 S SG   A CYS A 1 327 ? 10.70158  6.00617   -17.05641 0.650 15.92087  ?  408 CYS A SG   1 
ATOM   5331 S SG   B CYS A 1 327 ? 10.60926  6.48330   -17.72111 0.350 15.15012  ?  408 CYS A SG   1 
ATOM   5332 H HA   A CYS A 1 327 ? 10.31685  7.26039   -19.75129 0.650 17.28548  ?  408 CYS A HA   1 
ATOM   5333 H HA   B CYS A 1 327 ? 10.14752  7.45152   -20.55628 0.350 22.48388  ?  408 CYS A HA   1 
ATOM   5334 H HB2  A CYS A 1 327 ? 9.68554   8.22129   -16.95408 0.650 18.99344  ?  408 CYS A HB2  1 
ATOM   5335 H HB2  B CYS A 1 327 ? 9.31182   8.44585   -17.82128 0.350 20.16950  ?  408 CYS A HB2  1 
ATOM   5336 H HB3  A CYS A 1 327 ? 8.69911   7.09392   -17.92615 0.650 18.99344  ?  408 CYS A HB3  1 
ATOM   5337 H HB3  B CYS A 1 327 ? 8.58490   7.10541   -18.75064 0.350 20.16950  ?  408 CYS A HB3  1 
ATOM   5338 N N    A SER A 1 328 ? 9.89420   10.34725  -19.77651 0.650 20.41804  ?  409 SER A N    1 
ATOM   5339 N N    B SER A 1 328 ? 9.40754   10.49393  -20.60250 0.350 20.99653  ?  409 SER A N    1 
ATOM   5340 C CA   A SER A 1 328 ? 9.17267   11.43123  -20.44093 0.650 19.89371  ?  409 SER A CA   1 
ATOM   5341 C CA   B SER A 1 328 ? 8.58107   11.48414  -21.27950 0.350 17.12442  ?  409 SER A CA   1 
ATOM   5342 C C    A SER A 1 328 ? 9.64152   11.67728  -21.86589 0.650 24.76871  ?  409 SER A C    1 
ATOM   5343 C C    B SER A 1 328 ? 9.06634   11.75675  -22.69711 0.350 25.02328  ?  409 SER A C    1 
ATOM   5344 O O    A SER A 1 328 ? 9.08267   12.54603  -22.53751 0.650 25.00082  ?  409 SER A O    1 
ATOM   5345 O O    B SER A 1 328 ? 8.52013   12.63486  -23.37460 0.350 22.53433  ?  409 SER A O    1 
ATOM   5346 C CB   A SER A 1 328 ? 9.32481   12.74753  -19.64828 0.650 21.68394  ?  409 SER A CB   1 
ATOM   5347 C CB   B SER A 1 328 ? 8.52908   12.78822  -20.48645 0.350 17.09574  ?  409 SER A CB   1 
ATOM   5348 O OG   A SER A 1 328 ? 8.66467   12.65324  -18.40485 0.650 34.17779  ?  409 SER A OG   1 
ATOM   5349 O OG   B SER A 1 328 ? 8.05807   12.55503  -19.18032 0.350 20.62708  ?  409 SER A OG   1 
ATOM   5350 H HA   A SER A 1 328 ? 8.11776   11.15789  -20.46442 0.650 23.87245  ?  409 SER A HA   1 
ATOM   5351 H HA   B SER A 1 328 ? 7.56264   11.09926  -21.33199 0.350 20.54930  ?  409 SER A HA   1 
ATOM   5352 H HB2  A SER A 1 328 ? 10.38382  12.93976  -19.47612 0.650 26.02073  ?  409 SER A HB2  1 
ATOM   5353 H HB2  B SER A 1 328 ? 9.53171   13.21243  -20.43284 0.350 20.51489  ?  409 SER A HB2  1 
ATOM   5354 H HB3  A SER A 1 328 ? 8.88663   13.56299  -20.22372 0.650 26.02073  ?  409 SER A HB3  1 
ATOM   5355 H HB3  B SER A 1 328 ? 7.85643   13.48358  -20.98855 0.350 20.51489  ?  409 SER A HB3  1 
ATOM   5356 N N    A LEU A 1 329 ? 10.65367  10.93673  -22.35220 0.650 25.49857  ?  410 LEU A N    1 
ATOM   5357 N N    B LEU A 1 329 ? 10.07354  11.01759  -23.16903 0.350 19.56961  ?  410 LEU A N    1 
ATOM   5358 C CA   A LEU A 1 329 ? 11.14377  11.18538  -23.71113 0.650 24.26107  ?  410 LEU A CA   1 
ATOM   5359 C CA   B LEU A 1 329 ? 10.68503  11.32813  -24.43718 0.350 21.87992  ?  410 LEU A CA   1 
ATOM   5360 C C    A LEU A 1 329 ? 10.06554  10.89108  -24.75572 0.650 18.92662  ?  410 LEU A C    1 
ATOM   5361 C C    B LEU A 1 329 ? 9.67616   11.07766  -25.53876 0.350 26.59297  ?  410 LEU A C    1 
ATOM   5362 O O    A LEU A 1 329 ? 9.07597   10.20868  -24.46761 0.650 19.35426  ?  410 LEU A O    1 
ATOM   5363 O O    B LEU A 1 329 ? 8.66287   10.40000  -25.33478 0.350 22.13506  ?  410 LEU A O    1 
ATOM   5364 C CB   A LEU A 1 329 ? 12.42116  10.38203  -24.00150 0.650 21.33562  ?  410 LEU A CB   1 
ATOM   5365 C CB   B LEU A 1 329 ? 11.91423  10.45234  -24.67961 0.350 20.49293  ?  410 LEU A CB   1 
ATOM   5366 C CG   A LEU A 1 329 ? 13.56651  10.59775  -23.00508 0.650 24.27549  ?  410 LEU A CG   1 
ATOM   5367 C CG   B LEU A 1 329 ? 13.16262  10.82637  -23.88464 0.350 19.87008  ?  410 LEU A CG   1 
ATOM   5368 C CD1  A LEU A 1 329 ? 14.72718  9.63202   -23.22013 0.650 24.01966  ?  410 LEU A CD1  1 
ATOM   5369 C CD1  B LEU A 1 329 ? 14.30015  9.88925   -24.20367 0.350 22.33707  ?  410 LEU A CD1  1 
ATOM   5370 C CD2  A LEU A 1 329 ? 14.08847  12.02880  -23.07530 0.650 29.11028  ?  410 LEU A CD2  1 
ATOM   5371 C CD2  B LEU A 1 329 ? 13.55991  12.27020  -24.17116 0.350 20.32542  ?  410 LEU A CD2  1 
ATOM   5372 H HA   A LEU A 1 329 ? 11.38967  12.24429  -23.79086 0.650 29.11328  ?  410 LEU A HA   1 
ATOM   5373 H HA   B LEU A 1 329 ? 10.99921  12.37187  -24.43797 0.350 26.25590  ?  410 LEU A HA   1 
ATOM   5374 H HB2  A LEU A 1 329 ? 12.17075  9.32128   -23.98715 0.650 25.60274  ?  410 LEU A HB2  1 
ATOM   5375 H HB2  B LEU A 1 329 ? 11.65852  9.42582   -24.41701 0.350 24.59152  ?  410 LEU A HB2  1 
ATOM   5376 H HB3  A LEU A 1 329 ? 12.78836  10.66509  -24.98799 0.650 25.60274  ?  410 LEU A HB3  1 
ATOM   5377 H HB3  B LEU A 1 329 ? 12.17307  10.51331  -25.73668 0.350 24.59152  ?  410 LEU A HB3  1 
ATOM   5378 H HG   A LEU A 1 329 ? 13.15652  10.40597  -22.01350 0.650 29.13059  ?  410 LEU A HG   1 
ATOM   5379 H HG   B LEU A 1 329 ? 12.94549  10.73664  -22.82026 0.350 23.84410  ?  410 LEU A HG   1 
ATOM   5380 H HD11 A LEU A 1 329 ? 15.18453  9.83681   -24.18812 0.650 28.82359  ?  410 LEU A HD11 1 
ATOM   5381 H HD11 B LEU A 1 329 ? 15.06660  10.43568  -24.75328 0.350 26.80448  ?  410 LEU A HD11 1 
ATOM   5382 H HD12 A LEU A 1 329 ? 15.45943  9.77468   -22.42543 0.650 28.82359  ?  410 LEU A HD12 1 
ATOM   5383 H HD12 B LEU A 1 329 ? 14.71439  9.50387   -23.27201 0.350 26.80448  ?  410 LEU A HD12 1 
ATOM   5384 H HD13 A LEU A 1 329 ? 14.34778  8.61044   -23.19697 0.650 28.82359  ?  410 LEU A HD13 1 
ATOM   5385 H HD13 B LEU A 1 329 ? 13.92256  9.06661   -24.81094 0.350 26.80448  ?  410 LEU A HD13 1 
ATOM   5386 H HD21 A LEU A 1 329 ? 14.83092  12.09712  -23.87040 0.650 34.93234  ?  410 LEU A HD21 1 
ATOM   5387 H HD21 B LEU A 1 329 ? 13.45417  12.46214  -25.23891 0.350 24.39050  ?  410 LEU A HD21 1 
ATOM   5388 H HD22 A LEU A 1 329 ? 13.25596  12.70027  -23.28542 0.650 34.93234  ?  410 LEU A HD22 1 
ATOM   5389 H HD22 B LEU A 1 329 ? 12.90705  12.93648  -23.60730 0.350 24.39050  ?  410 LEU A HD22 1 
ATOM   5390 H HD23 A LEU A 1 329 ? 14.54293  12.28810  -22.11909 0.650 34.93234  ?  410 LEU A HD23 1 
ATOM   5391 H HD23 B LEU A 1 329 ? 14.59592  12.42016  -23.86736 0.350 24.39050  ?  410 LEU A HD23 1 
ATOM   5392 N N    A PRO A 1 330 ? 10.25405  11.35370  -26.00351 0.650 30.27481  ?  411 PRO A N    1 
ATOM   5393 N N    B PRO A 1 330 ? 9.94964   11.58334  -26.74047 0.350 22.91454  ?  411 PRO A N    1 
ATOM   5394 C CA   A PRO A 1 330 ? 9.17920   11.21795  -27.01364 0.650 25.77129  ?  411 PRO A CA   1 
ATOM   5395 C CA   B PRO A 1 330 ? 9.09061   11.24895  -27.87854 0.350 29.25180  ?  411 PRO A CA   1 
ATOM   5396 C C    A PRO A 1 330 ? 8.85365   9.78597   -27.44288 0.650 31.72724  ?  411 PRO A C    1 
ATOM   5397 C C    B PRO A 1 330 ? 8.98626   9.76358   -28.13052 0.350 26.33796  ?  411 PRO A C    1 
ATOM   5398 O O    A PRO A 1 330 ? 7.68767   9.47650   -27.73075 0.650 28.94934  ?  411 PRO A O    1 
ATOM   5399 O O    B PRO A 1 330 ? 8.07711   9.36057   -28.86879 0.350 24.74351  ?  411 PRO A O    1 
ATOM   5400 C CB   A PRO A 1 330 ? 9.68007   12.07487  -28.19582 0.650 33.57391  ?  411 PRO A CB   1 
ATOM   5401 C CB   B PRO A 1 330 ? 9.74586   11.98518  -29.05481 0.350 31.05095  ?  411 PRO A CB   1 
ATOM   5402 C CG   A PRO A 1 330 ? 10.77640  12.91381  -27.65386 0.650 27.92154  ?  411 PRO A CG   1 
ATOM   5403 C CG   B PRO A 1 330 ? 10.50847  13.09783  -28.40899 0.350 30.07895  ?  411 PRO A CG   1 
ATOM   5404 C CD   A PRO A 1 330 ? 11.37608  12.16873  -26.49646 0.650 32.93469  ?  411 PRO A CD   1 
ATOM   5405 C CD   B PRO A 1 330 ? 10.99890  12.54947  -27.10709 0.350 31.33199  ?  411 PRO A CD   1 
ATOM   5406 H HA   A PRO A 1 330 ? 8.27213   11.65620  -26.59737 0.650 30.92555  ?  411 PRO A HA   1 
ATOM   5407 H HA   B PRO A 1 330 ? 8.09089   11.65813  -27.73277 0.350 35.10216  ?  411 PRO A HA   1 
ATOM   5408 H HB2  A PRO A 1 330 ? 10.04732  11.42511  -28.99019 0.650 40.28869  ?  411 PRO A HB2  1 
ATOM   5409 H HB2  B PRO A 1 330 ? 10.41239  11.31213  -29.59410 0.350 37.26114  ?  411 PRO A HB2  1 
ATOM   5410 H HB3  A PRO A 1 330 ? 8.86620   12.69651  -28.56902 0.650 40.28869  ?  411 PRO A HB3  1 
ATOM   5411 H HB3  B PRO A 1 330 ? 8.98095   12.37129  -29.72856 0.350 37.26114  ?  411 PRO A HB3  1 
ATOM   5412 H HG2  A PRO A 1 330 ? 11.52425  13.07654  -28.42996 0.650 33.50585  ?  411 PRO A HG2  1 
ATOM   5413 H HG2  B PRO A 1 330 ? 11.34415  13.38947  -29.04515 0.350 36.09473  ?  411 PRO A HG2  1 
ATOM   5414 H HG3  A PRO A 1 330 ? 10.36991  13.86907  -27.32167 0.650 33.50585  ?  411 PRO A HG3  1 
ATOM   5415 H HG3  B PRO A 1 330 ? 9.84902   13.95023  -28.24574 0.350 36.09473  ?  411 PRO A HG3  1 
ATOM   5416 H HD2  A PRO A 1 330 ? 12.19986  11.53603  -26.82686 0.650 39.52162  ?  411 PRO A HD2  1 
ATOM   5417 H HD2  B PRO A 1 330 ? 11.96052  12.05161  -27.23162 0.350 37.59838  ?  411 PRO A HD2  1 
ATOM   5418 H HD3  A PRO A 1 330 ? 11.72173  12.85934  -25.72724 0.650 39.52162  ?  411 PRO A HD3  1 
ATOM   5419 H HD3  B PRO A 1 330 ? 11.08132  13.33768  -26.35873 0.350 37.59838  ?  411 PRO A HD3  1 
ATOM   5420 N N    . ASP A 1 331 ? 9.85955   8.92186   -27.55114 1.000 27.12373  ?  412 ASP A N    1 
ATOM   5421 C CA   . ASP A 1 331 ? 9.70973   7.49905   -27.81915 1.000 23.29644  ?  412 ASP A CA   1 
ATOM   5422 C C    . ASP A 1 331 ? 9.25825   6.67673   -26.61215 1.000 21.15772  ?  412 ASP A C    1 
ATOM   5423 O O    . ASP A 1 331 ? 9.26607   5.45083   -26.68685 1.000 22.21740  ?  412 ASP A O    1 
ATOM   5424 C CB   . ASP A 1 331 ? 11.00009  6.91629   -28.41632 1.000 25.84911  ?  412 ASP A CB   1 
ATOM   5425 C CG   . ASP A 1 331 ? 12.21159  7.11915   -27.53854 1.000 23.43105  ?  412 ASP A CG   1 
ATOM   5426 O OD1  . ASP A 1 331 ? 12.11805  7.65688   -26.47870 1.000 27.72663  ?  412 ASP A OD1  1 
ATOM   5427 O OD2  . ASP A 1 331 ? 13.38746  6.67786   -27.98901 1.000 23.50123  -1 412 ASP A OD2  1 
ATOM   5428 H H    A ASP A 1 331 ? 10.83786  9.19325   -27.45282 0.000 32.54848  ?  412 ASP A H    1 
ATOM   5429 D D    B ASP A 1 331 ? 10.62596  9.19103   -26.93424 1.000 32.54848  ?  412 ASP A D    1 
ATOM   5430 H HA   . ASP A 1 331 ? 8.92622   7.39939   -28.57033 1.000 27.95573  ?  412 ASP A HA   1 
ATOM   5431 H HB2  . ASP A 1 331 ? 10.86846  5.84403   -28.56137 1.000 31.01893  ?  412 ASP A HB2  1 
ATOM   5432 H HB3  . ASP A 1 331 ? 11.19586  7.40064   -29.37298 1.000 31.01893  ?  412 ASP A HB3  1 
ATOM   5433 D DD2  . ASP A 1 331 ? 14.09927  6.89221   -27.29060 0.860 28.20147  ?  412 ASP A DD2  1 
ATOM   5434 N N    . ALA A 1 332 ? 8.86996   7.31465   -25.51910 1.000 22.67106  ?  413 ALA A N    1 
ATOM   5435 C CA   . ALA A 1 332 ? 8.32866   6.61832   -24.35515 1.000 18.35858  ?  413 ALA A CA   1 
ATOM   5436 C C    . ALA A 1 332 ? 6.81348   6.73329   -24.38598 1.000 21.95614  ?  413 ALA A C    1 
ATOM   5437 O O    . ALA A 1 332 ? 6.28025   7.83412   -24.61321 1.000 24.10411  ?  413 ALA A O    1 
ATOM   5438 C CB   . ALA A 1 332 ? 8.86867   7.24757   -23.07879 1.000 18.90881  ?  413 ALA A CB   1 
ATOM   5439 H H    A ALA A 1 332 ? 8.91712   8.32710   -25.40451 1.000 27.20528  ?  413 ALA A H    1 
ATOM   5440 D D    B ALA A 1 332 ? 8.91784   8.32726   -25.40625 0.000 27.20528  ?  413 ALA A D    1 
ATOM   5441 H HA   . ALA A 1 332 ? 8.60614   5.56439   -24.37368 1.000 22.03030  ?  413 ALA A HA   1 
ATOM   5442 H HB1  . ALA A 1 332 ? 8.50051   8.27080   -23.00431 1.000 22.69057  ?  413 ALA A HB1  1 
ATOM   5443 H HB2  . ALA A 1 332 ? 8.52516   6.66577   -22.22344 1.000 22.69057  ?  413 ALA A HB2  1 
ATOM   5444 H HB3  . ALA A 1 332 ? 9.95804   7.24626   -23.11586 1.000 22.69057  ?  413 ALA A HB3  1 
ATOM   5445 N N    . ALA A 1 333 ? 6.11387   5.62792   -24.13932 1.000 18.35554  ?  414 ALA A N    1 
ATOM   5446 C CA   . ALA A 1 333 ? 4.65398   5.64081   -24.10906 1.000 19.42993  ?  414 ALA A CA   1 
ATOM   5447 C C    . ALA A 1 333 ? 4.19375   6.38707   -22.85773 1.000 20.37862  ?  414 ALA A C    1 
ATOM   5448 O O    . ALA A 1 333 ? 4.71850   6.16372   -21.75639 1.000 19.60184  ?  414 ALA A O    1 
ATOM   5449 C CB   . ALA A 1 333 ? 4.09749   4.22733   -24.11361 1.000 20.88146  ?  414 ALA A CB   1 
ATOM   5450 H H    A ALA A 1 333 ? 6.52560   4.71261   -23.95744 1.000 22.02665  ?  414 ALA A H    1 
ATOM   5451 D D    B ALA A 1 333 ? 6.52430   4.71206   -23.95729 0.000 22.02665  ?  414 ALA A D    1 
ATOM   5452 H HA   . ALA A 1 333 ? 4.26975   6.14302   -24.99689 1.000 23.31592  ?  414 ALA A HA   1 
ATOM   5453 H HB1  . ALA A 1 333 ? 4.59491   3.65262   -24.89488 1.000 25.05775  ?  414 ALA A HB1  1 
ATOM   5454 H HB2  . ALA A 1 333 ? 4.28186   3.77023   -23.14141 1.000 25.05775  ?  414 ALA A HB2  1 
ATOM   5455 H HB3  . ALA A 1 333 ? 3.02571   4.26853   -24.30772 1.000 25.05775  ?  414 ALA A HB3  1 
ATOM   5456 N N    . GLN A 1 334 ? 3.22788   7.29451   -23.03366 1.000 21.72122  ?  415 GLN A N    1 
ATOM   5457 C CA   . GLN A 1 334 ? 2.77734   8.20208   -21.98188 1.000 20.75547  ?  415 GLN A CA   1 
ATOM   5458 C C    . GLN A 1 334 ? 1.27396   8.42259   -22.10661 1.000 27.13351  ?  415 GLN A C    1 
ATOM   5459 O O    . GLN A 1 334 ? 0.71174   8.30776   -23.20479 1.000 25.88555  ?  415 GLN A O    1 
ATOM   5460 C CB   . GLN A 1 334 ? 3.45523   9.56769   -22.12792 1.000 23.80265  ?  415 GLN A CB   1 
ATOM   5461 C CG   . GLN A 1 334 ? 4.94104   9.50420   -22.09617 1.000 35.99557  ?  415 GLN A CG   1 
ATOM   5462 C CD   . GLN A 1 334 ? 5.58045   10.79406  -22.53622 1.000 42.02186  ?  415 GLN A CD   1 
ATOM   5463 O OE1  . GLN A 1 334 ? 5.28976   11.85436  -21.97632 1.000 41.17678  ?  415 GLN A OE1  1 
ATOM   5464 N NE2  . GLN A 1 334 ? 6.47939   10.71486  -23.52622 1.000 30.43491  ?  415 GLN A NE2  1 
ATOM   5465 H H    A GLN A 1 334 ? 2.73053   7.42415   -23.91470 0.090 26.06546  ?  415 GLN A H    1 
ATOM   5466 D D    B GLN A 1 334 ? 2.73175   7.42250   -23.91564 0.910 26.06546  ?  415 GLN A D    1 
ATOM   5467 H HA   . GLN A 1 334 ? 2.99590   7.76603   -21.00710 1.000 24.90656  ?  415 GLN A HA   1 
ATOM   5468 H HB2  . GLN A 1 334 ? 3.16090   10.00498  -23.08199 1.000 28.56317  ?  415 GLN A HB2  1 
ATOM   5469 H HB3  . GLN A 1 334 ? 3.13172   10.20916  -21.30819 1.000 28.56317  ?  415 GLN A HB3  1 
ATOM   5470 H HG2  . GLN A 1 334 ? 5.26737   9.29475   -21.07747 1.000 43.19469  ?  415 GLN A HG2  1 
ATOM   5471 H HG3  . GLN A 1 334 ? 5.27860   8.71318   -22.76583 1.000 43.19469  ?  415 GLN A HG3  1 
ATOM   5472 N N    . PRO A 1 335 ? 0.59025   8.71469   -20.99117 1.000 24.38632  ?  416 PRO A N    1 
ATOM   5473 C CA   . PRO A 1 335 ? 1.07582   8.71535   -19.63133 1.000 18.86722  ?  416 PRO A CA   1 
ATOM   5474 C C    . PRO A 1 335 ? 1.36081   7.29730   -19.12400 1.000 22.94246  ?  416 PRO A C    1 
ATOM   5475 O O    . PRO A 1 335 ? 0.66593   6.33697   -19.49394 1.000 24.74674  ?  416 PRO A O    1 
ATOM   5476 C CB   . PRO A 1 335 ? -0.09310  9.35736   -18.87233 1.000 23.67628  ?  416 PRO A CB   1 
ATOM   5477 C CG   . PRO A 1 335 ? -1.24782  9.00111   -19.62349 1.000 27.22519  ?  416 PRO A CG   1 
ATOM   5478 C CD   . PRO A 1 335 ? -0.83381  9.09321   -21.04366 1.000 22.95530  ?  416 PRO A CD   1 
ATOM   5479 H HA   . PRO A 1 335 ? 1.97164   9.32488   -19.51266 1.000 22.64067  ?  416 PRO A HA   1 
ATOM   5480 H HB2  . PRO A 1 335 ? -0.14531  8.95645   -17.86008 1.000 28.41153  ?  416 PRO A HB2  1 
ATOM   5481 H HB3  . PRO A 1 335 ? 0.03376   10.43942  -18.83867 1.000 28.41153  ?  416 PRO A HB3  1 
ATOM   5482 H HG2  . PRO A 1 335 ? -1.55346  7.98523   -19.37315 1.000 32.67023  ?  416 PRO A HG2  1 
ATOM   5483 H HG3  . PRO A 1 335 ? -2.05830  9.69776   -19.40926 1.000 32.67023  ?  416 PRO A HG3  1 
ATOM   5484 H HD2  . PRO A 1 335 ? -1.40049  8.39669   -21.66158 1.000 27.54636  ?  416 PRO A HD2  1 
ATOM   5485 H HD3  . PRO A 1 335 ? -0.95427  10.10889  -21.42046 1.000 27.54636  ?  416 PRO A HD3  1 
ATOM   5486 N N    . ALA A 1 336 ? 2.36195   7.17444   -18.25724 1.000 20.60212  ?  417 ALA A N    1 
ATOM   5487 C CA   . ALA A 1 336 ? 2.74985   5.87521   -17.74548 1.000 18.38717  ?  417 ALA A CA   1 
ATOM   5488 C C    . ALA A 1 336 ? 2.68800   5.86359   -16.23659 1.000 19.12619  ?  417 ALA A C    1 
ATOM   5489 O O    . ALA A 1 336 ? 3.09592   6.84624   -15.59105 1.000 21.67507  ?  417 ALA A O    1 
ATOM   5490 C CB   . ALA A 1 336 ? 4.21324   5.59348   -18.15255 1.000 22.41013  ?  417 ALA A CB   1 
ATOM   5491 H H    A ALA A 1 336 ? 2.91451   7.95282   -17.89778 0.040 24.72255  ?  417 ALA A H    1 
ATOM   5492 D D    B ALA A 1 336 ? 2.91400   7.95341   -17.89829 0.960 24.72255  ?  417 ALA A D    1 
ATOM   5493 H HA   . ALA A 1 336 ? 2.08396   5.10464   -18.13397 1.000 22.06460  ?  417 ALA A HA   1 
ATOM   5494 H HB1  . ALA A 1 336 ? 4.43671   4.54261   -17.96865 1.000 26.89216  ?  417 ALA A HB1  1 
ATOM   5495 H HB2  . ALA A 1 336 ? 4.33688   5.81999   -19.21157 1.000 26.89216  ?  417 ALA A HB2  1 
ATOM   5496 H HB3  . ALA A 1 336 ? 4.87459   6.22371   -17.55797 1.000 26.89216  ?  417 ALA A HB3  1 
ATOM   5497 N N    . PRO A 1 337 ? 2.22310   4.75595   -15.64554 1.000 19.75070  ?  418 PRO A N    1 
ATOM   5498 C CA   . PRO A 1 337 ? 2.15588   4.65662   -14.18121 1.000 22.30867  ?  418 PRO A CA   1 
ATOM   5499 C C    . PRO A 1 337 ? 3.48815   4.32459   -13.52032 1.000 20.56238  ?  418 PRO A C    1 
ATOM   5500 O O    . PRO A 1 337 ? 4.54224   4.35715   -14.16151 1.000 22.07242  ?  418 PRO A O    1 
ATOM   5501 C CB   . PRO A 1 337 ? 1.13438   3.53334   -13.97511 1.000 21.75420  ?  418 PRO A CB   1 
ATOM   5502 C CG   . PRO A 1 337 ? 1.44628   2.59287   -15.14264 1.000 23.15155  ?  418 PRO A CG   1 
ATOM   5503 C CD   . PRO A 1 337 ? 1.75427   3.51733   -16.29992 1.000 18.94090  ?  418 PRO A CD   1 
ATOM   5504 H HA   . PRO A 1 337 ? 1.78890   5.59319   -13.76136 1.000 26.77040  ?  418 PRO A HA   1 
ATOM   5505 H HB2  . PRO A 1 337 ? 1.29058   3.04466   -13.01339 1.000 26.10503  ?  418 PRO A HB2  1 
ATOM   5506 H HB3  . PRO A 1 337 ? 0.11829   3.92339   -14.03440 1.000 26.10503  ?  418 PRO A HB3  1 
ATOM   5507 H HG2  . PRO A 1 337 ? 2.30617   1.96835   -14.90045 1.000 27.78187  ?  418 PRO A HG2  1 
ATOM   5508 H HG3  . PRO A 1 337 ? 0.58070   1.96725   -15.36053 1.000 27.78187  ?  418 PRO A HG3  1 
ATOM   5509 H HD2  . PRO A 1 337 ? 2.53513   3.09605   -16.93307 1.000 22.72908  ?  418 PRO A HD2  1 
ATOM   5510 H HD3  . PRO A 1 337 ? 0.85814   3.70824   -16.89035 1.000 22.72908  ?  418 PRO A HD3  1 
ATOM   5511 N N    . GLU A 1 338 ? 3.45080   4.01303   -12.22143 1.000 22.93323  ?  419 GLU A N    1 
ATOM   5512 C CA   . GLU A 1 338 ? 4.67332   3.80328   -11.46954 1.000 23.10513  ?  419 GLU A CA   1 
ATOM   5513 C C    . GLU A 1 338 ? 5.35175   2.50554   -11.89594 1.000 20.96518  ?  419 GLU A C    1 
ATOM   5514 O O    . GLU A 1 338 ? 4.69340   1.55158   -12.33688 1.000 22.31887  ?  419 GLU A O    1 
ATOM   5515 C CB   . GLU A 1 338 ? 4.36282   3.74062   -9.96826  1.000 30.59023  ?  419 GLU A CB   1 
ATOM   5516 C CG   . GLU A 1 338 ? 4.05274   5.10442   -9.31614  1.000 31.96363  ?  419 GLU A CG   1 
ATOM   5517 C CD   . GLU A 1 338 ? 5.27396   5.99173   -9.21592  1.000 32.07195  ?  419 GLU A CD   1 
ATOM   5518 O OE1  . GLU A 1 338 ? 6.39804   5.45481   -9.19170  1.000 33.09810  ?  419 GLU A OE1  1 
ATOM   5519 O OE2  . GLU A 1 338 ? 5.11731   7.23402   -9.15585  1.000 34.22022  -1 419 GLU A OE2  1 
ATOM   5520 H H    A GLU A 1 338 ? 2.59637   3.90191   -11.67554 0.190 27.51987  ?  419 GLU A H    1 
ATOM   5521 D D    B GLU A 1 338 ? 2.59715   3.90161   -11.67438 0.810 27.51987  ?  419 GLU A D    1 
ATOM   5522 H HA   . GLU A 1 338 ? 5.35812   4.63084   -11.65471 1.000 27.72616  ?  419 GLU A HA   1 
ATOM   5523 H HB2  . GLU A 1 338 ? 3.49254   3.10104   -9.82113  1.000 36.70828  ?  419 GLU A HB2  1 
ATOM   5524 H HB3  . GLU A 1 338 ? 5.22633   3.31943   -9.45342  1.000 36.70828  ?  419 GLU A HB3  1 
ATOM   5525 H HG2  . GLU A 1 338 ? 3.30579   5.62421   -9.91613  1.000 38.35636  ?  419 GLU A HG2  1 
ATOM   5526 H HG3  . GLU A 1 338 ? 3.67193   4.93869   -8.30837  1.000 38.35636  ?  419 GLU A HG3  1 
ATOM   5527 N N    . ALA A 1 339 ? 6.67665   2.47426   -11.73960 1.000 21.99906  ?  420 ALA A N    1 
ATOM   5528 C CA   . ALA A 1 339 ? 7.46210   1.28987   -12.09831 1.000 24.95601  ?  420 ALA A CA   1 
ATOM   5529 C C    . ALA A 1 339 ? 6.90968   0.04731   -11.41995 1.000 22.43662  ?  420 ALA A C    1 
ATOM   5530 O O    . ALA A 1 339 ? 6.58944   0.06208   -10.23010 1.000 23.13187  ?  420 ALA A O    1 
ATOM   5531 C CB   . ALA A 1 339 ? 8.92219   1.46142   -11.67617 1.000 25.68972  ?  420 ALA A CB   1 
ATOM   5532 H H    A ALA A 1 339 ? 7.23271   3.24550   -11.37028 0.140 26.39888  ?  420 ALA A H    1 
ATOM   5533 D D    B ALA A 1 339 ? 7.23397   3.24466   -11.37044 0.860 26.39888  ?  420 ALA A D    1 
ATOM   5534 H HA   . ALA A 1 339 ? 7.41472   1.16556   -13.18016 1.000 29.94722  ?  420 ALA A HA   1 
ATOM   5535 H HB1  . ALA A 1 339 ? 9.29316   2.41187   -12.05973 1.000 30.82767  ?  420 ALA A HB1  1 
ATOM   5536 H HB2  . ALA A 1 339 ? 8.98040   1.45167   -10.58777 1.000 30.82767  ?  420 ALA A HB2  1 
ATOM   5537 H HB3  . ALA A 1 339 ? 9.50926   0.64014   -12.08717 1.000 30.82767  ?  420 ALA A HB3  1 
ATOM   5538 N N    . GLY A 1 340 ? 6.79776   -1.03847  -12.17926 1.000 23.20513  ?  421 GLY A N    1 
ATOM   5539 C CA   . GLY A 1 340 ? 6.33254   -2.28234  -11.63451 1.000 22.55389  ?  421 GLY A CA   1 
ATOM   5540 C C    . GLY A 1 340 ? 4.84513   -2.48619  -11.69206 1.000 26.11693  ?  421 GLY A C    1 
ATOM   5541 O O    . GLY A 1 340 ? 4.39172   -3.63129  -11.60340 1.000 33.57833  ?  421 GLY A O    1 
ATOM   5542 H H    A GLY A 1 340 ? 7.02521   -1.07296  -13.17298 0.000 27.84616  ?  421 GLY A H    1 
ATOM   5543 D D    B GLY A 1 340 ? 7.02556   -1.07162  -13.17294 1.000 27.84616  ?  421 GLY A D    1 
ATOM   5544 H HA2  . GLY A 1 340 ? 6.80042   -3.09945  -12.18363 1.000 27.06467  ?  421 GLY A HA2  1 
ATOM   5545 H HA3  . GLY A 1 340 ? 6.63447   -2.33889  -10.58869 1.000 27.06467  ?  421 GLY A HA3  1 
ATOM   5546 N N    . THR A 1 341 ? 4.07129   -1.43389  -11.84228 1.000 23.31629  ?  422 THR A N    1 
ATOM   5547 C CA   . THR A 1 341 ? 2.62327   -1.59792  -11.89782 1.000 23.34839  ?  422 THR A CA   1 
ATOM   5548 C C    . THR A 1 341 ? 2.18158   -1.90594  -13.32869 1.000 20.83611  ?  422 THR A C    1 
ATOM   5549 O O    . THR A 1 341 ? 2.93772   -1.74011  -14.29251 1.000 22.20325  ?  422 THR A O    1 
ATOM   5550 C CB   . THR A 1 341 ? 1.88720   -0.36992  -11.33585 1.000 27.65016  ?  422 THR A CB   1 
ATOM   5551 O OG1  . THR A 1 341 ? 2.03304   0.72921   -12.22534 1.000 27.05911  ?  422 THR A OG1  1 
ATOM   5552 C CG2  . THR A 1 341 ? 2.42736   0.01147   -9.96135  1.000 30.94349  ?  422 THR A CG2  1 
ATOM   5553 H H    A THR A 1 341 ? 4.40163   -0.47261  -11.92731 0.000 27.97955  ?  422 THR A H    1 
ATOM   5554 D D    B THR A 1 341 ? 4.40225   -0.47282  -11.92725 1.000 27.97955  ?  422 THR A D    1 
ATOM   5555 H HA   . THR A 1 341 ? 2.33373   -2.43928  -11.26823 1.000 28.01807  ?  422 THR A HA   1 
ATOM   5556 H HB   . THR A 1 341 ? 0.82927   -0.60891  -11.22738 1.000 33.18019  ?  422 THR A HB   1 
ATOM   5557 H HG1  A THR A 1 341 ? 2.95314   1.06521   -12.19493 0.000 32.47093  ?  422 THR A HG1  1 
ATOM   5558 D DG1  B THR A 1 341 ? 2.94308   1.08831   -12.16803 1.000 32.47093  ?  422 THR A DG1  1 
ATOM   5559 H HG21 . THR A 1 341 ? 2.33350   -0.83158  -9.27684  1.000 37.13218  ?  422 THR A HG21 1 
ATOM   5560 H HG22 . THR A 1 341 ? 3.47848   0.28964   -10.03791 1.000 37.13218  ?  422 THR A HG22 1 
ATOM   5561 H HG23 . THR A 1 341 ? 1.86617   0.85601   -9.56145  1.000 37.13218  ?  422 THR A HG23 1 
ATOM   5562 N N    . TRP A 1 342 ? 0.96477   -2.41450  -13.46021 1.000 22.16800  ?  423 TRP A N    1 
ATOM   5563 C CA   . TRP A 1 342 ? 0.47966   -2.86539  -14.75385 1.000 18.32955  ?  423 TRP A CA   1 
ATOM   5564 C C    . TRP A 1 342 ? 0.14847   -1.67450  -15.63545 1.000 20.94232  ?  423 TRP A C    1 
ATOM   5565 O O    . TRP A 1 342 ? -0.46339  -0.69457  -15.19010 1.000 22.12067  ?  423 TRP A O    1 
ATOM   5566 C CB   . TRP A 1 342 ? -0.76343  -3.71950  -14.57386 1.000 20.75252  ?  423 TRP A CB   1 
ATOM   5567 C CG   . TRP A 1 342 ? -1.11868  -4.44229  -15.81503 1.000 18.76825  ?  423 TRP A CG   1 
ATOM   5568 C CD1  . TRP A 1 342 ? -2.18033  -4.21484  -16.63211 1.000 20.06508  ?  423 TRP A CD1  1 
ATOM   5569 C CD2  . TRP A 1 342 ? -0.38785  -5.53294  -16.40528 1.000 19.05479  ?  423 TRP A CD2  1 
ATOM   5570 N NE1  . TRP A 1 342 ? -2.15835  -5.09123  -17.69280 1.000 22.17588  ?  423 TRP A NE1  1 
ATOM   5571 C CE2  . TRP A 1 342 ? -1.05833  -5.90940  -17.56798 1.000 20.03847  ?  423 TRP A CE2  1 
ATOM   5572 C CE3  . TRP A 1 342 ? 0.78773   -6.21889  -16.04994 1.000 18.44237  ?  423 TRP A CE3  1 
ATOM   5573 C CZ2  . TRP A 1 342 ? -0.61233  -6.94884  -18.37237 1.000 19.74869  ?  423 TRP A CZ2  1 
ATOM   5574 C CZ3  . TRP A 1 342 ? 1.22163   -7.23862  -16.85120 1.000 18.95564  ?  423 TRP A CZ3  1 
ATOM   5575 C CH2  . TRP A 1 342 ? 0.54351   -7.59538  -17.99354 1.000 18.46318  ?  423 TRP A CH2  1 
ATOM   5576 H H    A TRP A 1 342 ? 0.29686   -2.52674  -12.69752 0.170 26.60160  ?  423 TRP A H    1 
ATOM   5577 D D    B TRP A 1 342 ? 0.29583   -2.52734  -12.69852 0.830 26.60160  ?  423 TRP A D    1 
ATOM   5578 H HA   . TRP A 1 342 ? 1.24898   -3.46294  -15.24292 1.000 21.99546  ?  423 TRP A HA   1 
ATOM   5579 H HB2  . TRP A 1 342 ? -0.58316  -4.45488  -13.78976 1.000 24.90303  ?  423 TRP A HB2  1 
ATOM   5580 H HB3  . TRP A 1 342 ? -1.60190  -3.07951  -14.29912 1.000 24.90303  ?  423 TRP A HB3  1 
ATOM   5581 H HD1  . TRP A 1 342 ? -2.93229  -3.45629  -16.47224 1.000 24.07809  ?  423 TRP A HD1  1 
ATOM   5582 H HE1  A TRP A 1 342 ? -2.84399  -5.12846  -18.44707 0.000 26.61106  ?  423 TRP A HE1  1 
ATOM   5583 D DE1  B TRP A 1 342 ? -2.84399  -5.12846  -18.44707 1.000 26.61106  ?  423 TRP A DE1  1 
ATOM   5584 H HE3  . TRP A 1 342 ? 1.33715   -5.94541  -15.16126 1.000 22.13084  ?  423 TRP A HE3  1 
ATOM   5585 H HZ2  . TRP A 1 342 ? -1.15127  -7.23982  -19.26190 1.000 23.69843  ?  423 TRP A HZ2  1 
ATOM   5586 H HZ3  . TRP A 1 342 ? 2.11812   -7.77667  -16.58062 1.000 22.74677  ?  423 TRP A HZ3  1 
ATOM   5587 H HH2  . TRP A 1 342 ? 0.92512   -8.39890  -18.60602 1.000 22.15582  ?  423 TRP A HH2  1 
ATOM   5588 N N    . PHE A 1 343 ? 0.56722   -1.75818  -16.89906 1.000 19.03098  ?  424 PHE A N    1 
ATOM   5589 C CA   . PHE A 1 343 ? 0.42671   -0.67009  -17.87705 1.000 19.21618  ?  424 PHE A CA   1 
ATOM   5590 C C    . PHE A 1 343 ? -0.36930  -1.26673  -19.02573 1.000 19.39974  ?  424 PHE A C    1 
ATOM   5591 O O    . PHE A 1 343 ? 0.17657   -1.81542  -19.98812 1.000 18.00493  ?  424 PHE A O    1 
ATOM   5592 C CB   . PHE A 1 343 ? 1.81390   -0.20303  -18.30624 1.000 19.44203  ?  424 PHE A CB   1 
ATOM   5593 C CG   . PHE A 1 343 ? 1.84374   1.03356   -19.16645 1.000 17.65716  ?  424 PHE A CG   1 
ATOM   5594 C CD1  . PHE A 1 343 ? 0.65991   1.65111   -19.59881 1.000 21.53862  ?  424 PHE A CD1  1 
ATOM   5595 C CD2  . PHE A 1 343 ? 3.06816   1.58255   -19.53641 1.000 17.00393  ?  424 PHE A CD2  1 
ATOM   5596 C CE1  . PHE A 1 343 ? 0.70029   2.78218   -20.38975 1.000 20.69826  ?  424 PHE A CE1  1 
ATOM   5597 C CE2  . PHE A 1 343 ? 3.12474   2.70946   -20.32906 1.000 21.07694  ?  424 PHE A CE2  1 
ATOM   5598 C CZ   . PHE A 1 343 ? 1.92423   3.32478   -20.74874 1.000 22.68595  ?  424 PHE A CZ   1 
ATOM   5599 H H    A PHE A 1 343 ? 1.01910   -2.58645  -17.28658 1.000 22.83717  ?  424 PHE A H    1 
ATOM   5600 D D    B PHE A 1 343 ? 1.01884   -2.58784  -17.28389 0.000 22.83717  ?  424 PHE A D    1 
ATOM   5601 H HA   . PHE A 1 343 ? -0.11498  0.18658   -17.47608 1.000 23.05942  ?  424 PHE A HA   1 
ATOM   5602 H HB2  . PHE A 1 343 ? 2.39625   0.01104   -17.41006 1.000 23.33043  ?  424 PHE A HB2  1 
ATOM   5603 H HB3  . PHE A 1 343 ? 2.28527   -1.00495  -18.87442 1.000 23.33043  ?  424 PHE A HB3  1 
ATOM   5604 H HD1  . PHE A 1 343 ? -0.29440  1.23654   -19.30929 1.000 25.84634  ?  424 PHE A HD1  1 
ATOM   5605 H HD2  . PHE A 1 343 ? 3.98420   1.12070   -19.19884 1.000 20.40472  ?  424 PHE A HD2  1 
ATOM   5606 H HE1  . PHE A 1 343 ? -0.21705  3.24173   -20.72695 1.000 24.83792  ?  424 PHE A HE1  1 
ATOM   5607 H HE2  . PHE A 1 343 ? 4.07901   3.11837   -20.62663 1.000 25.29233  ?  424 PHE A HE2  1 
ATOM   5608 H HZ   . PHE A 1 343 ? 1.96024   4.22052   -21.35103 1.000 27.22314  ?  424 PHE A HZ   1 
ATOM   5609 N N    . GLN A 1 344 ? -1.69951  -1.15541  -18.93172 1.000 18.31441  ?  425 GLN A N    1 
ATOM   5610 C CA   . GLN A 1 344 ? -2.57938  -1.93192  -19.78613 1.000 18.50656  ?  425 GLN A CA   1 
ATOM   5611 C C    . GLN A 1 344 ? -2.44181  -1.56668  -21.25690 1.000 18.80367  ?  425 GLN A C    1 
ATOM   5612 O O    . GLN A 1 344 ? -2.39796  -2.45451  -22.12170 1.000 20.58973  ?  425 GLN A O    1 
ATOM   5613 C CB   . GLN A 1 344 ? -4.02433  -1.76016  -19.29758 1.000 21.35423  ?  425 GLN A CB   1 
ATOM   5614 C CG   . GLN A 1 344 ? -5.05135  -2.40097  -20.19135 1.000 19.23883  ?  425 GLN A CG   1 
ATOM   5615 C CD   . GLN A 1 344 ? -5.04550  -3.90371  -20.12284 1.000 24.76530  ?  425 GLN A CD   1 
ATOM   5616 O OE1  . GLN A 1 344 ? -4.54156  -4.48676  -19.17716 1.000 26.96078  ?  425 GLN A OE1  1 
ATOM   5617 N NE2  . GLN A 1 344 ? -5.61959  -4.53908  -21.12680 1.000 25.23883  ?  425 GLN A NE2  1 
ATOM   5618 H H    A GLN A 1 344 ? -2.18555  -0.54087  -18.27866 0.420 21.97729  ?  425 GLN A H    1 
ATOM   5619 D D    B GLN A 1 344 ? -2.18766  -0.54163  -18.27952 0.580 21.97729  ?  425 GLN A D    1 
ATOM   5620 H HA   . GLN A 1 344 ? -2.30367  -2.98379  -19.71096 1.000 22.20787  ?  425 GLN A HA   1 
ATOM   5621 H HB2  . GLN A 1 344 ? -4.11547  -2.21224  -18.30995 1.000 25.62507  ?  425 GLN A HB2  1 
ATOM   5622 H HB3  . GLN A 1 344 ? -4.25044  -0.69530  -19.24246 1.000 25.62507  ?  425 GLN A HB3  1 
ATOM   5623 H HG2  . GLN A 1 344 ? -6.04186  -2.05652  -19.89412 1.000 23.08660  ?  425 GLN A HG2  1 
ATOM   5624 H HG3  . GLN A 1 344 ? -4.85039  -2.11248  -21.22309 1.000 23.08660  ?  425 GLN A HG3  1 
ATOM   5625 H HE21 A GLN A 1 344 ? -5.64685  -5.55867  -21.13626 0.290 30.28659  ?  425 GLN A HE21 1 
ATOM   5626 D DE21 B GLN A 1 344 ? -5.64685  -5.55867  -21.13626 0.710 30.28659  ?  425 GLN A DE21 1 
ATOM   5627 H HE22 A GLN A 1 344 ? -6.03608  -4.01062  -21.89339 0.160 30.28659  ?  425 GLN A HE22 1 
ATOM   5628 D DE22 B GLN A 1 344 ? -6.03608  -4.01062  -21.89339 0.840 30.28659  ?  425 GLN A DE22 1 
ATOM   5629 N N    . ALA A 1 345 ? -2.39703  -0.27609  -21.57402 1.000 18.56115  ?  426 ALA A N    1 
ATOM   5630 C CA   . ALA A 1 345 ? -2.27967  0.12379   -22.97014 1.000 20.11420  ?  426 ALA A CA   1 
ATOM   5631 C C    . ALA A 1 345 ? -1.00348  -0.42891  -23.59086 1.000 22.77648  ?  426 ALA A C    1 
ATOM   5632 O O    . ALA A 1 345 ? -0.98249  -0.77578  -24.78015 1.000 20.89550  ?  426 ALA A O    1 
ATOM   5633 C CB   . ALA A 1 345 ? -2.30077  1.65119   -23.07561 1.000 23.15594  ?  426 ALA A CB   1 
ATOM   5634 H H    A ALA A 1 345 ? -2.43855  0.49473   -20.90730 0.000 22.27338  ?  426 ALA A H    1 
ATOM   5635 D D    B ALA A 1 345 ? -2.43836  0.49646   -20.90930 1.000 22.27338  ?  426 ALA A D    1 
ATOM   5636 H HA   . ALA A 1 345 ? -3.13037  -0.27141  -23.52533 1.000 24.13703  ?  426 ALA A HA   1 
ATOM   5637 H HB1  . ALA A 1 345 ? -2.62308  2.06836   -22.12157 1.000 27.78713  ?  426 ALA A HB1  1 
ATOM   5638 H HB2  . ALA A 1 345 ? -1.29789  2.00420   -23.31583 1.000 27.78713  ?  426 ALA A HB2  1 
ATOM   5639 H HB3  . ALA A 1 345 ? -2.99602  1.94299   -23.86275 1.000 27.78713  ?  426 ALA A HB3  1 
ATOM   5640 N N    . TYR A 1 346 ? 0.07879   -0.48052  -22.80173 1.000 18.01249  ?  427 TYR A N    1 
ATOM   5641 C CA   . TYR A 1 346 ? 1.35753   -0.99896  -23.29073 1.000 17.31732  ?  427 TYR A CA   1 
ATOM   5642 C C    . TYR A 1 346 ? 1.26310   -2.49077  -23.57594 1.000 16.33663  ?  427 TYR A C    1 
ATOM   5643 O O    . TYR A 1 346 ? 1.77324   -2.95553  -24.60162 1.000 16.99446  ?  427 TYR A O    1 
ATOM   5644 C CB   . TYR A 1 346 ? 2.44407   -0.71735  -22.24147 1.000 17.58942  ?  427 TYR A CB   1 
ATOM   5645 C CG   . TYR A 1 346 ? 3.84782   -0.79386  -22.80903 1.000 16.10714  ?  427 TYR A CG   1 
ATOM   5646 C CD1  . TYR A 1 346 ? 4.43408   0.30767   -23.43399 1.000 16.20687  ?  427 TYR A CD1  1 
ATOM   5647 C CD2  . TYR A 1 346 ? 4.56479   -1.99252  -22.76921 1.000 15.15176  ?  427 TYR A CD2  1 
ATOM   5648 C CE1  . TYR A 1 346 ? 5.69307   0.21803   -23.99378 1.000 15.27446  ?  427 TYR A CE1  1 
ATOM   5649 C CE2  . TYR A 1 346 ? 5.82326   -2.07095  -23.32369 1.000 14.25779  ?  427 TYR A CE2  1 
ATOM   5650 C CZ   . TYR A 1 346 ? 6.38314   -0.96801  -23.90817 1.000 14.55910  ?  427 TYR A CZ   1 
ATOM   5651 O OH   . TYR A 1 346 ? 7.64027   -1.06759  -24.48200 1.000 16.72752  ?  427 TYR A OH   1 
ATOM   5652 H H    A TYR A 1 346 ? 0.10049   -0.17365  -21.82923 0.000 21.61499  ?  427 TYR A H    1 
ATOM   5653 D D    B TYR A 1 346 ? 0.10311   -0.17434  -21.82907 1.000 21.61499  ?  427 TYR A D    1 
ATOM   5654 H HA   . TYR A 1 346 ? 1.62978   -0.49599  -24.21864 1.000 20.78079  ?  427 TYR A HA   1 
ATOM   5655 H HB2  . TYR A 1 346 ? 2.29736   0.28550   -21.84039 1.000 21.10730  ?  427 TYR A HB2  1 
ATOM   5656 H HB3  . TYR A 1 346 ? 2.36359   -1.45401  -21.44212 1.000 21.10730  ?  427 TYR A HB3  1 
ATOM   5657 H HD1  . TYR A 1 346 ? 3.89576   1.24280   -23.48040 1.000 19.44825  ?  427 TYR A HD1  1 
ATOM   5658 H HD2  . TYR A 1 346 ? 4.12954   -2.86288  -22.30078 1.000 18.18212  ?  427 TYR A HD2  1 
ATOM   5659 H HE1  . TYR A 1 346 ? 6.13072   1.06980   -24.49313 1.000 18.32936  ?  427 TYR A HE1  1 
ATOM   5660 H HE2  . TYR A 1 346 ? 6.36798   -3.00314  -23.29702 1.000 17.10935  ?  427 TYR A HE2  1 
ATOM   5661 H HH   A TYR A 1 346 ? 7.69407   -0.49195  -25.27329 0.260 20.07303  ?  427 TYR A HH   1 
ATOM   5662 D DH   B TYR A 1 346 ? 7.79312   -0.31232  -25.08748 0.740 20.07303  ?  427 TYR A DH   1 
ATOM   5663 N N    . PHE A 1 347 ? 0.64331   -3.25040  -22.66538 1.000 16.71772  ?  428 PHE A N    1 
ATOM   5664 C CA   . PHE A 1 347 ? 0.45078   -4.67982  -22.87889 1.000 17.74574  ?  428 PHE A CA   1 
ATOM   5665 C C    . PHE A 1 347 ? -0.35050  -4.93469  -24.14031 1.000 17.50200  ?  428 PHE A C    1 
ATOM   5666 O O    . PHE A 1 347 ? -0.02913  -5.83535  -24.92315 1.000 18.18434  ?  428 PHE A O    1 
ATOM   5667 C CB   . PHE A 1 347 ? -0.23161  -5.28857  -21.66641 1.000 17.61318  ?  428 PHE A CB   1 
ATOM   5668 C CG   . PHE A 1 347 ? -0.56998  -6.73252  -21.82305 1.000 18.63277  ?  428 PHE A CG   1 
ATOM   5669 C CD1  . PHE A 1 347 ? 0.41390   -7.71468  -21.70954 1.000 19.42126  ?  428 PHE A CD1  1 
ATOM   5670 C CD2  . PHE A 1 347 ? -1.86622  -7.13165  -22.09080 1.000 20.06373  ?  428 PHE A CD2  1 
ATOM   5671 C CE1  . PHE A 1 347 ? 0.08881   -9.07272  -21.86512 1.000 21.41586  ?  428 PHE A CE1  1 
ATOM   5672 C CE2  . PHE A 1 347 ? -2.18113  -8.46476  -22.23331 1.000 22.83270  ?  428 PHE A CE2  1 
ATOM   5673 C CZ   . PHE A 1 347 ? -1.19958  -9.43921  -22.12581 1.000 22.63572  ?  428 PHE A CZ   1 
ATOM   5674 H H    A PHE A 1 347 ? 0.26882   -2.90635  -21.78119 0.920 20.06126  ?  428 PHE A H    1 
ATOM   5675 D D    B PHE A 1 347 ? 0.26798   -2.90887  -21.78057 0.080 20.06126  ?  428 PHE A D    1 
ATOM   5676 H HA   . PHE A 1 347 ? 1.41997   -5.16448  -22.99662 1.000 21.29489  ?  428 PHE A HA   1 
ATOM   5677 H HB2  . PHE A 1 347 ? 0.43298   -5.19493  -20.80755 1.000 21.13581  ?  428 PHE A HB2  1 
ATOM   5678 H HB3  . PHE A 1 347 ? -1.15998  -4.74868  -21.48002 1.000 21.13581  ?  428 PHE A HB3  1 
ATOM   5679 H HD1  . PHE A 1 347 ? 1.43416   -7.42889  -21.50029 1.000 23.30552  ?  428 PHE A HD1  1 
ATOM   5680 H HD2  . PHE A 1 347 ? -2.64277  -6.38761  -22.18960 1.000 24.07648  ?  428 PHE A HD2  1 
ATOM   5681 H HE1  . PHE A 1 347 ? 0.85795   -9.82591  -21.77847 1.000 25.69903  ?  428 PHE A HE1  1 
ATOM   5682 H HE2  . PHE A 1 347 ? -3.20262  -8.75452  -22.43077 1.000 27.39924  ?  428 PHE A HE2  1 
ATOM   5683 H HZ   . PHE A 1 347 ? -1.45362  -10.48180 -22.24772 1.000 27.16286  ?  428 PHE A HZ   1 
ATOM   5684 N N    . GLN A 1 348 ? -1.41586  -4.16133  -24.34932 1.000 19.66130  ?  429 GLN A N    1 
ATOM   5685 C CA   . GLN A 1 348 ? -2.23890  -4.39856  -25.52774 1.000 21.09261  ?  429 GLN A CA   1 
ATOM   5686 C C    . GLN A 1 348 ? -1.43496  -4.22329  -26.80315 1.000 17.97088  ?  429 GLN A C    1 
ATOM   5687 O O    . GLN A 1 348 ? -1.57482  -5.00531  -27.75238 1.000 18.96592  ?  429 GLN A O    1 
ATOM   5688 C CB   . GLN A 1 348 ? -3.45200  -3.46197  -25.51486 1.000 22.43546  ?  429 GLN A CB   1 
ATOM   5689 C CG   . GLN A 1 348 ? -4.45586  -3.84376  -26.58863 1.000 35.13751  ?  429 GLN A CG   1 
ATOM   5690 C CD   . GLN A 1 348 ? -5.75048  -3.08567  -26.45028 1.000 47.64251  ?  429 GLN A CD   1 
ATOM   5691 O OE1  . GLN A 1 348 ? -6.18569  -2.78268  -25.33946 1.000 41.17644  ?  429 GLN A OE1  1 
ATOM   5692 N NE2  . GLN A 1 348 ? -6.37347  -2.77005  -27.58517 1.000 41.52145  ?  429 GLN A NE2  1 
ATOM   5693 H H    A GLN A 1 348 ? -1.72077  -3.39661  -23.74712 0.790 23.59356  ?  429 GLN A H    1 
ATOM   5694 D D    B GLN A 1 348 ? -1.72277  -3.39615  -23.74872 0.210 23.59356  ?  429 GLN A D    1 
ATOM   5695 H HA   . GLN A 1 348 ? -2.60643  -5.42444  -25.50335 1.000 25.31113  ?  429 GLN A HA   1 
ATOM   5696 H HB2  . GLN A 1 348 ? -3.94524  -3.52359  -24.54480 1.000 26.92256  ?  429 GLN A HB2  1 
ATOM   5697 H HB3  . GLN A 1 348 ? -3.12104  -2.44017  -25.70056 1.000 26.92256  ?  429 GLN A HB3  1 
ATOM   5698 H HG2  . GLN A 1 348 ? -4.03408  -3.62048  -27.56860 1.000 42.16501  ?  429 GLN A HG2  1 
ATOM   5699 H HG3  . GLN A 1 348 ? -4.67536  -4.90861  -26.51107 1.000 42.16501  ?  429 GLN A HG3  1 
ATOM   5700 N N    . THR A 1 349 ? -0.55270  -3.22781  -26.84062 1.000 17.36884  ?  430 THR A N    1 
ATOM   5701 C CA   . THR A 1 349 ? 0.31305   -3.06786  -28.00106 1.000 16.44253  ?  430 THR A CA   1 
ATOM   5702 C C    . THR A 1 349 ? 1.34241   -4.18895  -28.10157 1.000 18.87537  ?  430 THR A C    1 
ATOM   5703 O O    . THR A 1 349 ? 1.67417   -4.63101  -29.20485 1.000 19.06746  ?  430 THR A O    1 
ATOM   5704 C CB   . THR A 1 349 ? 0.97258   -1.70572  -27.95249 1.000 16.92008  ?  430 THR A CB   1 
ATOM   5705 O OG1  . THR A 1 349 ? -0.08258  -0.72175  -27.96749 1.000 24.46022  ?  430 THR A OG1  1 
ATOM   5706 C CG2  . THR A 1 349 ? 1.87004   -1.48124  -29.14603 1.000 21.22045  ?  430 THR A CG2  1 
ATOM   5707 H H    A THR A 1 349 ? -0.41707  -2.53520  -26.10421 0.060 20.84261  ?  430 THR A H    1 
ATOM   5708 D D    B THR A 1 349 ? -0.41518  -2.53405  -26.10564 0.940 20.84261  ?  430 THR A D    1 
ATOM   5709 H HA   . THR A 1 349 ? -0.28999  -3.11709  -28.90771 1.000 19.73104  ?  430 THR A HA   1 
ATOM   5710 H HB   . THR A 1 349 ? 1.59358   -1.61745  -27.06105 1.000 20.30409  ?  430 THR A HB   1 
ATOM   5711 H HG1  A THR A 1 349 ? 0.29849   0.17926   -27.90945 0.240 29.35227  ?  430 THR A HG1  1 
ATOM   5712 D DG1  B THR A 1 349 ? 0.29239   0.17385   -27.83447 0.760 29.35227  ?  430 THR A DG1  1 
ATOM   5713 H HG21 . THR A 1 349 ? 2.87480   -1.22088  -28.81322 1.000 25.46453  ?  430 THR A HG21 1 
ATOM   5714 H HG22 . THR A 1 349 ? 1.92106   -2.38734  -29.74976 1.000 25.46453  ?  430 THR A HG22 1 
ATOM   5715 H HG23 . THR A 1 349 ? 1.47894   -0.66926  -29.75907 1.000 25.46453  ?  430 THR A HG23 1 
ATOM   5716 N N    . LEU A 1 350 ? 1.89291   -4.64821  -26.96414 1.000 15.67808  ?  431 LEU A N    1 
ATOM   5717 C CA   . LEU A 1 350 ? 2.83921   -5.76773  -27.02665 1.000 15.81179  ?  431 LEU A CA   1 
ATOM   5718 C C    . LEU A 1 350 ? 2.19992   -6.96822  -27.70286 1.000 15.18838  ?  431 LEU A C    1 
ATOM   5719 O O    . LEU A 1 350 ? 2.84812   -7.68444  -28.46770 1.000 16.25988  ?  431 LEU A O    1 
ATOM   5720 C CB   . LEU A 1 350 ? 3.32461   -6.15291  -25.63225 1.000 15.91198  ?  431 LEU A CB   1 
ATOM   5721 C CG   . LEU A 1 350 ? 4.37613   -5.26030  -24.98064 1.000 14.30486  ?  431 LEU A CG   1 
ATOM   5722 C CD1  . LEU A 1 350 ? 4.49330   -5.66507  -23.51105 1.000 16.71123  ?  431 LEU A CD1  1 
ATOM   5723 C CD2  . LEU A 1 350 ? 5.70109   -5.37276  -25.67812 1.000 16.57700  ?  431 LEU A CD2  1 
ATOM   5724 H H    A LEU A 1 350 ? 1.71110   -4.28219  -26.02959 1.000 18.81370  ?  431 LEU A H    1 
ATOM   5725 D D    B LEU A 1 350 ? 1.71275   -4.28396  -26.02859 0.000 18.81370  ?  431 LEU A D    1 
ATOM   5726 H HA   . LEU A 1 350 ? 3.70925   -5.45132  -27.60199 1.000 18.97415  ?  431 LEU A HA   1 
ATOM   5727 H HB2  . LEU A 1 350 ? 2.46018   -6.15824  -24.96829 1.000 19.09438  ?  431 LEU A HB2  1 
ATOM   5728 H HB3  . LEU A 1 350 ? 3.75389   -7.15295  -25.69341 1.000 19.09438  ?  431 LEU A HB3  1 
ATOM   5729 H HG   . LEU A 1 350 ? 4.08073   -4.21367  -25.05403 1.000 17.16584  ?  431 LEU A HG   1 
ATOM   5730 H HD11 . LEU A 1 350 ? 5.04436   -6.60313  -23.44418 1.000 20.05347  ?  431 LEU A HD11 1 
ATOM   5731 H HD12 . LEU A 1 350 ? 5.02414   -4.88266  -22.96871 1.000 20.05347  ?  431 LEU A HD12 1 
ATOM   5732 H HD13 . LEU A 1 350 ? 3.49297   -5.79129  -23.09690 1.000 20.05347  ?  431 LEU A HD13 1 
ATOM   5733 H HD21 . LEU A 1 350 ? 6.39973   -4.66706  -25.22870 1.000 19.89240  ?  431 LEU A HD21 1 
ATOM   5734 H HD22 . LEU A 1 350 ? 6.07621   -6.38996  -25.56549 1.000 19.89240  ?  431 LEU A HD22 1 
ATOM   5735 H HD23 . LEU A 1 350 ? 5.56673   -5.14100  -26.73469 1.000 19.89240  ?  431 LEU A HD23 1 
ATOM   5736 N N    . VAL A 1 351 ? 0.93077   -7.21508  -27.39339 1.000 16.71914  ?  432 VAL A N    1 
ATOM   5737 C CA   . VAL A 1 351 ? 0.20718   -8.32932  -28.00317 1.000 17.26841  ?  432 VAL A CA   1 
ATOM   5738 C C    . VAL A 1 351 ? -0.03505  -8.06765  -29.48599 1.000 18.69733  ?  432 VAL A C    1 
ATOM   5739 O O    . VAL A 1 351 ? 0.18585   -8.93658  -30.32688 1.000 20.72357  ?  432 VAL A O    1 
ATOM   5740 C CB   . VAL A 1 351 ? -1.11235  -8.55230  -27.25845 1.000 17.88174  ?  432 VAL A CB   1 
ATOM   5741 C CG1  . VAL A 1 351 ? -1.98476  -9.57014  -27.97304 1.000 24.13012  ?  432 VAL A CG1  1 
ATOM   5742 C CG2  . VAL A 1 351 ? -0.86213  -9.00422  -25.82617 1.000 19.05690  ?  432 VAL A CG2  1 
ATOM   5743 H H    A VAL A 1 351 ? 0.37865   -6.66965  -26.73152 0.820 20.06297  ?  432 VAL A H    1 
ATOM   5744 D D    B VAL A 1 351 ? 0.37695   -6.67094  -26.73188 0.180 20.06297  ?  432 VAL A D    1 
ATOM   5745 H HA   . VAL A 1 351 ? 0.81608   -9.22963  -27.92080 1.000 20.72209  ?  432 VAL A HA   1 
ATOM   5746 H HB   . VAL A 1 351 ? -1.64322  -7.60058  -27.23607 1.000 21.45808  ?  432 VAL A HB   1 
ATOM   5747 H HG11 . VAL A 1 351 ? -2.95953  -9.60580  -27.48658 1.000 28.95615  ?  432 VAL A HG11 1 
ATOM   5748 H HG12 . VAL A 1 351 ? -2.09986  -9.26993  -29.01454 1.000 28.95615  ?  432 VAL A HG12 1 
ATOM   5749 H HG13 . VAL A 1 351 ? -1.50627  -10.54800 -27.91878 1.000 28.95615  ?  432 VAL A HG13 1 
ATOM   5750 H HG21 . VAL A 1 351 ? -0.12370  -8.34494  -25.36991 1.000 22.86828  ?  432 VAL A HG21 1 
ATOM   5751 H HG22 . VAL A 1 351 ? -1.79824  -8.95521  -25.26993 1.000 22.86828  ?  432 VAL A HG22 1 
ATOM   5752 H HG23 . VAL A 1 351 ? -0.48950  -10.02849 -25.83720 1.000 22.86828  ?  432 VAL A HG23 1 
ATOM   5753 N N    A SER A 1 352 ? -0.50252  -6.86717  -29.82855 0.530 18.76369  ?  433 SER A N    1 
ATOM   5754 N N    B SER A 1 352 ? -0.50058  -6.86197  -29.82140 0.470 18.76037  ?  433 SER A N    1 
ATOM   5755 C CA   A SER A 1 352 ? -0.86783  -6.62319  -31.22424 0.530 18.42087  ?  433 SER A CA   1 
ATOM   5756 C CA   B SER A 1 352 ? -0.87194  -6.57467  -31.20802 0.470 18.62002  ?  433 SER A CA   1 
ATOM   5757 C C    A SER A 1 352 ? 0.34591   -6.58812  -32.13914 0.530 21.74208  ?  433 SER A C    1 
ATOM   5758 C C    B SER A 1 352 ? 0.34142   -6.59754  -32.12698 0.470 21.72447  ?  433 SER A C    1 
ATOM   5759 O O    A SER A 1 352 ? 0.25809   -7.00796  -33.29621 0.530 24.42918  ?  433 SER A O    1 
ATOM   5760 O O    B SER A 1 352 ? 0.25470   -7.04606  -33.27484 0.470 24.44543  ?  433 SER A O    1 
ATOM   5761 C CB   A SER A 1 352 ? -1.59939  -5.28180  -31.33136 0.530 25.44923  ?  433 SER A CB   1 
ATOM   5762 C CB   B SER A 1 352 ? -1.51590  -5.18867  -31.27305 0.470 24.99075  ?  433 SER A CB   1 
ATOM   5763 O OG   A SER A 1 352 ? -2.01816  -5.04640  -32.66220 0.530 35.01248  ?  433 SER A OG   1 
ATOM   5764 O OG   B SER A 1 352 ? -2.73304  -5.16223  -30.55387 0.470 27.05794  ?  433 SER A OG   1 
ATOM   5765 H H    A SER A 1 352 ? -0.63447  -6.07888  -29.19483 0.530 22.51643  ?  433 SER A H    1 
ATOM   5766 H H    B SER A 1 352 ? -0.62919  -6.08348  -29.17503 0.470 22.51245  ?  433 SER A H    1 
ATOM   5767 H HA   A SER A 1 352 ? -1.52360  -7.43041  -31.55053 0.530 22.10504  ?  433 SER A HA   1 
ATOM   5768 H HA   B SER A 1 352 ? -1.57946  -7.33192  -31.54577 0.470 22.34402  ?  433 SER A HA   1 
ATOM   5769 H HB2  A SER A 1 352 ? -2.47417  -5.30090  -30.68137 0.530 30.53908  ?  433 SER A HB2  1 
ATOM   5770 H HB2  B SER A 1 352 ? -0.83191  -4.45947  -30.83886 0.470 29.98890  ?  433 SER A HB2  1 
ATOM   5771 H HB3  A SER A 1 352 ? -0.92425  -4.48301  -31.02442 0.530 30.53908  ?  433 SER A HB3  1 
ATOM   5772 H HB3  B SER A 1 352 ? -1.71469  -4.93890  -32.31526 0.470 29.98890  ?  433 SER A HB3  1 
ATOM   5773 N N    . ALA A 1 353 ? 1.47724   -6.10865  -31.64069 1.000 18.53876  ?  434 ALA A N    1 
ATOM   5774 C CA   . ALA A 1 353 ? 2.68950   -5.96343  -32.42342 1.000 17.12189  ?  434 ALA A CA   1 
ATOM   5775 C C    . ALA A 1 353 ? 3.64914   -7.14272  -32.25822 1.000 18.06311  ?  434 ALA A C    1 
ATOM   5776 O O    . ALA A 1 353 ? 4.78092   -7.05936  -32.71913 1.000 19.87518  ?  434 ALA A O    1 
ATOM   5777 C CB   . ALA A 1 353 ? 3.40815   -4.66826  -32.04170 1.000 19.76289  ?  434 ALA A CB   1 
ATOM   5778 H H    A ALA A 1 353 ? 1.58452   -5.80551  -30.67271 1.000 22.24651  ?  434 ALA A H    1 
ATOM   5779 D D    B ALA A 1 353 ? 1.58548   -5.79633  -30.67574 0.000 22.24651  ?  434 ALA A D    1 
ATOM   5780 H HA   . ALA A 1 353 ? 2.40777   -5.90511  -33.47477 1.000 20.54626  ?  434 ALA A HA   1 
ATOM   5781 H HB1  . ALA A 1 353 ? 2.80545   -3.81949  -32.36487 1.000 23.71547  ?  434 ALA A HB1  1 
ATOM   5782 H HB2  . ALA A 1 353 ? 3.53918   -4.64068  -30.95995 1.000 23.71547  ?  434 ALA A HB2  1 
ATOM   5783 H HB3  . ALA A 1 353 ? 4.38002   -4.64315  -32.53459 1.000 23.71547  ?  434 ALA A HB3  1 
ATOM   5784 N N    . ALA A 1 354 ? 3.22021   -8.21308  -31.59780 1.000 17.85789  ?  435 ALA A N    1 
ATOM   5785 C CA   . ALA A 1 354 ? 4.09102   -9.36925  -31.39058 1.000 17.96845  ?  435 ALA A CA   1 
ATOM   5786 C C    . ALA A 1 354 ? 4.64585   -9.85610  -32.71929 1.000 18.56319  ?  435 ALA A C    1 
ATOM   5787 O O    . ALA A 1 354 ? 3.91813   -9.94198  -33.71610 1.000 21.71680  ?  435 ALA A O    1 
ATOM   5788 C CB   . ALA A 1 354 ? 3.30329   -10.49118 -30.72292 1.000 22.19630  ?  435 ALA A CB   1 
ATOM   5789 H H    A ALA A 1 354 ? 2.28725   -8.31245  -31.19764 1.000 21.42946  ?  435 ALA A H    1 
ATOM   5790 D D    B ALA A 1 354 ? 2.28762   -8.31382  -31.19714 0.000 21.42946  ?  435 ALA A D    1 
ATOM   5791 H HA   . ALA A 1 354 ? 4.92347   -9.09078  -30.74438 1.000 21.56214  ?  435 ALA A HA   1 
ATOM   5792 H HB1  . ALA A 1 354 ? 3.03513   -10.18370 -29.71216 1.000 26.63556  ?  435 ALA A HB1  1 
ATOM   5793 H HB2  . ALA A 1 354 ? 2.40170   -10.68606 -31.30367 1.000 26.63556  ?  435 ALA A HB2  1 
ATOM   5794 H HB3  . ALA A 1 354 ? 3.92304   -11.38712 -30.68678 1.000 26.63556  ?  435 ALA A HB3  1 
ATOM   5795 N N    . ASN A 1 355 ? 5.94622   -10.17530 -32.74201 1.000 19.36234  ?  436 ASN A N    1 
ATOM   5796 C CA   . ASN A 1 355 ? 6.59046   -10.78346 -33.89633 1.000 21.68299  ?  436 ASN A CA   1 
ATOM   5797 C C    . ASN A 1 355 ? 7.53582   -11.85923 -33.38470 1.000 21.30352  ?  436 ASN A C    1 
ATOM   5798 O O    . ASN A 1 355 ? 8.55933   -11.51379 -32.78685 1.000 23.76415  ?  436 ASN A O    1 
ATOM   5799 C CB   . ASN A 1 355 ? 7.35223   -9.71164  -34.66004 1.000 21.83020  ?  436 ASN A CB   1 
ATOM   5800 C CG   . ASN A 1 355 ? 8.13477   -10.25196 -35.83224 1.000 37.49115  ?  436 ASN A CG   1 
ATOM   5801 O OD1  . ASN A 1 355 ? 7.70428   -11.18378 -36.49307 1.000 34.67507  ?  436 ASN A OD1  1 
ATOM   5802 N ND2  . ASN A 1 355 ? 9.30805   -9.67558  -36.07860 1.000 37.30484  ?  436 ASN A ND2  1 
ATOM   5803 H H    A ASN A 1 355 ? 6.58282   -10.01949 -31.96043 0.910 23.23481  ?  436 ASN A H    1 
ATOM   5804 D D    B ASN A 1 355 ? 6.58268   -10.01941 -31.96033 0.090 23.23481  ?  436 ASN A D    1 
ATOM   5805 H HA   . ASN A 1 355 ? 5.86804   -11.23821 -34.57412 1.000 26.01958  ?  436 ASN A HA   1 
ATOM   5806 H HB2  . ASN A 1 355 ? 6.64147   -8.97898  -35.04231 1.000 26.19624  ?  436 ASN A HB2  1 
ATOM   5807 H HB3  . ASN A 1 355 ? 8.05654   -9.22935  -33.98222 1.000 26.19624  ?  436 ASN A HB3  1 
ATOM   5808 N N    . PRO A 1 356 ? 7.26609   -13.15846 -33.61874 1.000 22.17568  ?  437 PRO A N    1 
ATOM   5809 C CA   . PRO A 1 356 ? 6.16533   -13.66676 -34.45383 1.000 22.17136  ?  437 PRO A CA   1 
ATOM   5810 C C    . PRO A 1 356 ? 4.81916   -13.40849 -33.81491 1.000 27.70998  ?  437 PRO A C    1 
ATOM   5811 O O    . PRO A 1 356 ? 4.72930   -13.21885 -32.60102 1.000 23.27504  ?  437 PRO A O    1 
ATOM   5812 C CB   . PRO A 1 356 ? 6.42053   -15.19206 -34.50845 1.000 30.89543  ?  437 PRO A CB   1 
ATOM   5813 C CG   . PRO A 1 356 ? 7.81365   -15.38478 -34.03672 1.000 33.94561  ?  437 PRO A CG   1 
ATOM   5814 C CD   . PRO A 1 356 ? 8.14060   -14.24308 -33.12532 1.000 27.81070  ?  437 PRO A CD   1 
ATOM   5815 H HA   . PRO A 1 356 ? 6.21243   -13.24401 -35.45741 1.000 26.60564  ?  437 PRO A HA   1 
ATOM   5816 H HB2  . PRO A 1 356 ? 5.71602   -15.70615 -33.85463 1.000 37.07452  ?  437 PRO A HB2  1 
ATOM   5817 H HB3  . PRO A 1 356 ? 6.30615   -15.54734 -35.53255 1.000 37.07452  ?  437 PRO A HB3  1 
ATOM   5818 H HG2  . PRO A 1 356 ? 7.88480   -16.33096 -33.50027 1.000 40.73473  ?  437 PRO A HG2  1 
ATOM   5819 H HG3  . PRO A 1 356 ? 8.48679   -15.39075 -34.89401 1.000 40.73473  ?  437 PRO A HG3  1 
ATOM   5820 H HD2  . PRO A 1 356 ? 7.90493   -14.49199 -32.09062 1.000 33.37285  ?  437 PRO A HD2  1 
ATOM   5821 H HD3  . PRO A 1 356 ? 9.19101   -13.96516 -33.21193 1.000 33.37285  ?  437 PRO A HD3  1 
ATOM   5822 N N    . PRO A 1 357 ? 3.74778   -13.43169 -34.60157 1.000 24.28154  ?  438 PRO A N    1 
ATOM   5823 C CA   . PRO A 1 357 ? 2.43242   -13.17456 -34.02178 1.000 22.94902  ?  438 PRO A CA   1 
ATOM   5824 C C    . PRO A 1 357 ? 2.05815   -14.24029 -33.00997 1.000 21.88966  ?  438 PRO A C    1 
ATOM   5825 O O    . PRO A 1 357 ? 2.48955   -15.39295 -33.09362 1.000 26.02572  ?  438 PRO A O    1 
ATOM   5826 C CB   . PRO A 1 357 ? 1.49321   -13.21195 -35.24384 1.000 29.38459  ?  438 PRO A CB   1 
ATOM   5827 C CG   . PRO A 1 357 ? 2.38833   -12.84869 -36.39618 1.000 30.39362  ?  438 PRO A CG   1 
ATOM   5828 C CD   . PRO A 1 357 ? 3.69834   -13.51999 -36.07628 1.000 32.96616  ?  438 PRO A CD   1 
ATOM   5829 H HA   . PRO A 1 357 ? 2.39804   -12.19068 -33.55391 1.000 27.53882  ?  438 PRO A HA   1 
ATOM   5830 H HB2  . PRO A 1 357 ? 1.07621   -14.21140 -35.36755 1.000 35.26151  ?  438 PRO A HB2  1 
ATOM   5831 H HB3  . PRO A 1 357 ? 0.68989   -12.48511 -35.12346 1.000 35.26151  ?  438 PRO A HB3  1 
ATOM   5832 H HG2  . PRO A 1 357 ? 1.97071   -13.22775 -37.32892 1.000 36.47234  ?  438 PRO A HG2  1 
ATOM   5833 H HG3  . PRO A 1 357 ? 2.50557   -11.76650 -36.45281 1.000 36.47234  ?  438 PRO A HG3  1 
ATOM   5834 H HD2  . PRO A 1 357 ? 3.69739   -14.55866 -36.40683 1.000 39.55939  ?  438 PRO A HD2  1 
ATOM   5835 H HD3  . PRO A 1 357 ? 4.53341   -12.98544 -36.52906 1.000 39.55939  ?  438 PRO A HD3  1 
ATOM   5836 N N    . LEU A 1 358 ? 1.26120   -13.83819 -32.03182 1.000 24.70178  ?  439 LEU A N    1 
ATOM   5837 C CA   . LEU A 1 358 ? 0.69404   -14.77427 -31.09395 1.000 28.62436  ?  439 LEU A CA   1 
ATOM   5838 C C    . LEU A 1 358 ? -0.44707  -15.55342 -31.76558 1.000 39.10026  ?  439 LEU A C    1 
ATOM   5839 O O    . LEU A 1 358 ? -0.91209  -15.19026 -32.84259 0.840 36.45866  ?  439 LEU A O    1 
ATOM   5840 C CB   . LEU A 1 358 ? 0.19353   -14.04901 -29.85296 1.000 22.54684  ?  439 LEU A CB   1 
ATOM   5841 C CG   . LEU A 1 358 ? 1.29924   -13.45239 -28.98662 1.000 23.76910  ?  439 LEU A CG   1 
ATOM   5842 C CD1  . LEU A 1 358 ? 0.69152   -12.40571 -28.06587 1.000 28.75439  ?  439 LEU A CD1  1 
ATOM   5843 C CD2  . LEU A 1 358 ? 2.01543   -14.50135 -28.18741 1.000 30.53003  ?  439 LEU A CD2  1 
ATOM   5844 O OXT  . LEU A 1 358 ? -0.93442  -16.54058 -31.23068 1.000 39.51314  ?  439 LEU A OXT  1 
ATOM   5845 H H    A LEU A 1 358 ? 0.99324   -12.86772 -31.86815 0.230 29.64213  ?  439 LEU A H    1 
ATOM   5846 D D    B LEU A 1 358 ? 0.99324   -12.86772 -31.86815 0.770 29.64213  ?  439 LEU A D    1 
ATOM   5847 H HA   . LEU A 1 358 ? 1.45383   -15.48438 -30.76754 1.000 34.34924  ?  439 LEU A HA   1 
ATOM   5848 H HB2  . LEU A 1 358 ? -0.45807  -13.23333 -30.16632 1.000 27.05621  ?  439 LEU A HB2  1 
ATOM   5849 H HB3  . LEU A 1 358 ? -0.36356  -14.75607 -29.23829 1.000 27.05621  ?  439 LEU A HB3  1 
ATOM   5850 H HG   . LEU A 1 358 ? 2.04626   -12.98924 -29.63126 1.000 28.52292  ?  439 LEU A HG   1 
ATOM   5851 H HD11 . LEU A 1 358 ? 0.51112   -11.49395 -28.63529 1.000 34.50527  ?  439 LEU A HD11 1 
ATOM   5852 H HD12 . LEU A 1 358 ? -0.24849  -12.78689 -27.66688 1.000 34.50527  ?  439 LEU A HD12 1 
ATOM   5853 H HD13 . LEU A 1 358 ? 1.38649   -12.20357 -27.25085 1.000 34.50527  ?  439 LEU A HD13 1 
ATOM   5854 H HD21 . LEU A 1 358 ? 2.25966   -15.33952 -28.84003 1.000 36.63603  ?  439 LEU A HD21 1 
ATOM   5855 H HD22 . LEU A 1 358 ? 2.92900   -14.07196 -27.77618 1.000 36.63603  ?  439 LEU A HD22 1 
ATOM   5856 H HD23 . LEU A 1 358 ? 1.36570   -14.83672 -27.37903 1.000 36.63603  ?  439 LEU A HD23 1 
HETATM 5857 O O    . HOH B 2 .   ? 18.17448  10.09468  -25.41631 1.000 35.61613  ?  501 HOH A O    1 
HETATM 5858 O O    . HOH B 2 .   ? -6.70364  -2.74992  -23.28252 1.000 33.66507  ?  502 HOH A O    1 
HETATM 5859 O O    . HOH B 2 .   ? 12.43672  14.03395  -20.81143 1.000 40.08974  ?  503 HOH A O    1 
HETATM 5860 O O    . HOH B 2 .   ? 19.23847  -0.94157  8.36059   1.000 40.55498  ?  504 HOH A O    1 
HETATM 5861 O O    . HOH B 2 .   ? 34.678    9.746     -18.655   1.000 32.86251  ?  505 HOH A O    1 
HETATM 5862 D D2   . HOH B 2 .   ? 35.407    10.346    -18.740   1.000 39.43501  ?  505 HOH A D2   1 
HETATM 5863 O O    . HOH B 2 .   ? -1.11490  0.53705   -13.19753 1.000 37.91582  ?  506 HOH A O    1 
HETATM 5864 O O    . HOH B 2 .   ? 24.025    -28.395   -24.726   1.000 37.50374  ?  507 HOH A O    1 
HETATM 5865 O O    . HOH B 2 .   ? 14.43679  12.61300  -13.27559 1.000 39.21286  ?  508 HOH A O    1 
HETATM 5866 O O    . HOH B 2 .   ? 31.91366  -7.78962  -34.17087 1.000 38.21852  ?  509 HOH A O    1 
HETATM 5867 O O    . HOH B 2 .   ? 6.37416   -13.61036 -11.39961 1.000 26.72252  ?  510 HOH A O    1 
HETATM 5868 O O    . HOH B 2 .   ? 17.93748  6.86460   -15.56093 1.000 31.61718  ?  511 HOH A O    1 
HETATM 5869 O O    . HOH B 2 .   ? 13.03383  11.35719  -9.15617  1.000 41.14062  ?  512 HOH A O    1 
HETATM 5870 O O    . HOH B 2 .   ? 21.38374  -30.72871 -16.37946 1.000 28.00623  ?  513 HOH A O    1 
HETATM 5871 D D1   . HOH B 2 .   ? 21.70002  -30.81908 -17.28364 1.000 33.60748  ?  513 HOH A D1   1 
HETATM 5872 O O    . HOH B 2 .   ? 25.360    9.062     -38.878   1.000 29.81862  ?  514 HOH A O    1 
HETATM 5873 O O    . HOH B 2 .   ? 12.50328  -1.63020  -16.80776 1.000 40.59371  ?  515 HOH A O    1 
HETATM 5874 O O    . HOH B 2 .   ? 8.37996   -7.81690  -11.86563 1.000 31.03429  ?  516 HOH A O    1 
HETATM 5875 D D1   . HOH B 2 .   ? 8.42291   -7.43366  -11.00766 1.000 37.24115  ?  516 HOH A D1   1 
HETATM 5876 O O    . HOH B 2 .   ? 28.55024  -27.71530 -19.26257 1.000 39.33813  ?  517 HOH A O    1 
HETATM 5877 O O    . HOH B 2 .   ? 12.33318  0.12316   -14.37424 1.000 36.12723  ?  518 HOH A O    1 
HETATM 5878 O O    . HOH B 2 .   ? 14.12798  -1.11968  -19.63933 1.000 24.96956  ?  519 HOH A O    1 
HETATM 5879 D D2   . HOH B 2 .   ? 14.09100  -0.41640  -20.26423 1.000 29.96347  ?  519 HOH A D2   1 
HETATM 5880 O O    . HOH B 2 .   ? 10.57647  5.22809   -11.59923 1.000 39.06881  ?  520 HOH A O    1 
HETATM 5881 O O    . HOH B 2 .   ? -0.66771  9.86258   -24.72265 1.000 39.36840  ?  521 HOH A O    1 
HETATM 5882 O O    . HOH B 2 .   ? 23.05812  -10.30347 -37.16082 1.000 30.19568  ?  522 HOH A O    1 
HETATM 5883 O O    . HOH B 2 .   ? 27.00650  4.86897   -3.42275  1.000 24.39737  ?  523 HOH A O    1 
HETATM 5884 D D1   . HOH B 2 .   ? 27.44772  4.85645   -4.26381  0.720 29.27685  ?  523 HOH A D1   1 
HETATM 5885 O O    . HOH B 2 .   ? -1.79935  -7.45295  -34.79986 1.000 40.79797  ?  524 HOH A O    1 
HETATM 5886 O O    . HOH B 2 .   ? 5.07957   9.20268   -26.45264 1.000 43.10182  ?  525 HOH A O    1 
HETATM 5887 O O    . HOH B 2 .   ? 10.68001  -5.40525  1.21703   1.000 30.62838  ?  526 HOH A O    1 
HETATM 5888 O O    . HOH B 2 .   ? 20.14881  -19.27386 4.82898   1.000 31.83331  ?  527 HOH A O    1 
HETATM 5889 O O    . HOH B 2 .   ? 18.15780  1.33432   -24.18419 1.000 34.62635  ?  528 HOH A O    1 
HETATM 5890 O O    . HOH B 2 .   ? 1.91421   -14.66503 -6.49211  1.000 36.46753  ?  529 HOH A O    1 
HETATM 5891 O O    . HOH B 2 .   ? 7.86288   -10.19950 -8.22759  1.000 30.19464  ?  530 HOH A O    1 
HETATM 5892 O O    . HOH B 2 .   ? 8.90300   4.54466   -30.53227 1.000 30.55720  ?  531 HOH A O    1 
HETATM 5893 D D1   . HOH B 2 .   ? 9.81716   4.39563   -30.29269 1.000 36.66864  ?  531 HOH A D1   1 
HETATM 5894 D D2   . HOH B 2 .   ? 8.54707   3.70044   -30.79589 0.760 36.66864  ?  531 HOH A D2   1 
HETATM 5895 O O    . HOH B 2 .   ? 18.86558  1.22278   -3.12667  1.000 29.31457  ?  532 HOH A O    1 
HETATM 5896 O O    . HOH B 2 .   ? 1.84161   -21.88299 -12.27295 1.000 36.07546  ?  533 HOH A O    1 
HETATM 5897 O O    . HOH B 2 .   ? 1.42309   -9.35182  -34.23318 1.000 29.42287  ?  534 HOH A O    1 
HETATM 5898 D D2   . HOH B 2 .   ? 0.70008   -8.94427  -33.78067 1.000 35.30745  ?  534 HOH A D2   1 
HETATM 5899 O O    . HOH B 2 .   ? 15.03532  -13.83565 -31.59101 1.000 34.13660  ?  535 HOH A O    1 
HETATM 5900 O O    . HOH B 2 .   ? 30.43293  -10.70119 2.33499   1.000 19.22131  ?  536 HOH A O    1 
HETATM 5901 D D1   . HOH B 2 .   ? 30.57518  -11.16513 3.14552   1.000 23.06558  ?  536 HOH A D1   1 
HETATM 5902 O O    . HOH B 2 .   ? 32.13140  -21.39656 -4.83896  1.000 33.07189  ?  537 HOH A O    1 
HETATM 5903 D D1   . HOH B 2 .   ? 32.70890  -21.34097 -5.59315  0.880 39.68627  ?  537 HOH A D1   1 
HETATM 5904 D D2   . HOH B 2 .   ? 32.03777  -20.50431 -4.50949  0.870 39.68627  ?  537 HOH A D2   1 
HETATM 5905 O O    . HOH B 2 .   ? 8.09937   4.98755   -11.15798 1.000 30.22491  ?  538 HOH A O    1 
HETATM 5906 D D1   . HOH B 2 .   ? 8.85829   5.19090   -11.69990 0.940 36.26990  ?  538 HOH A D1   1 
HETATM 5907 O O    . HOH B 2 .   ? 27.46117  4.22654   -19.41684 1.000 29.75305  ?  539 HOH A O    1 
HETATM 5908 O O    . HOH B 2 .   ? 10.09779  7.28793   -13.84499 1.000 31.92310  ?  540 HOH A O    1 
HETATM 5909 D D2   . HOH B 2 .   ? 9.52148   7.28208   -14.59532 0.990 38.30771  ?  540 HOH A D2   1 
HETATM 5910 O O    . HOH B 2 .   ? 20.35191  0.08065   -41.38824 1.000 44.80906  ?  541 HOH A O    1 
HETATM 5911 O O    . HOH B 2 .   ? 24.18253  -12.85931 6.78324   1.000 34.96659  ?  542 HOH A O    1 
HETATM 5912 O O    . HOH B 2 .   ? 31.17897  0.41505   -1.52201  1.000 21.44193  ?  543 HOH A O    1 
HETATM 5913 D D1   . HOH B 2 .   ? 31.14485  1.27509   -1.89574  1.000 25.73032  ?  543 HOH A D1   1 
HETATM 5914 O O    . HOH B 2 .   ? -1.19630  5.40370   -17.83886 1.000 41.32146  ?  544 HOH A O    1 
HETATM 5915 O O    . HOH B 2 .   ? 5.21517   -6.22688  -35.21331 1.000 33.06336  ?  545 HOH A O    1 
HETATM 5916 O O    . HOH B 2 .   ? 10.22155  -11.09751 3.81613   1.000 33.33844  ?  546 HOH A O    1 
HETATM 5917 O O    . HOH B 2 .   ? 35.59520  3.16986   -6.39223  1.000 38.76856  ?  547 HOH A O    1 
HETATM 5918 O O    . HOH B 2 .   ? 36.27195  -10.41540 -29.43800 1.000 36.44277  ?  548 HOH A O    1 
HETATM 5919 D D2   . HOH B 2 .   ? 36.18156  -11.30572 -29.13961 1.000 43.73133  ?  548 HOH A D2   1 
HETATM 5920 O O    . HOH B 2 .   ? 6.21976   -0.77019  -20.32311 1.000 23.61527  ?  549 HOH A O    1 
HETATM 5921 D D1   . HOH B 2 .   ? 6.38903   0.01035   -19.80406 1.000 28.33832  ?  549 HOH A D1   1 
HETATM 5922 D D2   . HOH B 2 .   ? 5.91087   -0.48273  -21.17325 0.680 28.33832  ?  549 HOH A D2   1 
HETATM 5923 O O    . HOH B 2 .   ? 5.26271   -26.21453 -15.31714 1.000 22.37255  ?  550 HOH A O    1 
HETATM 5924 D D1   . HOH B 2 .   ? 5.80903   -26.47600 -14.56797 1.000 26.84706  ?  550 HOH A D1   1 
HETATM 5925 D D2   . HOH B 2 .   ? 4.57314   -25.63149 -14.99304 0.620 26.84706  ?  550 HOH A D2   1 
HETATM 5926 O O    . HOH B 2 .   ? 23.52494  -9.94589  7.52034   1.000 33.01624  ?  551 HOH A O    1 
HETATM 5927 O O    . HOH B 2 .   ? 22.55751  -29.88672 -11.09917 1.000 23.32173  ?  552 HOH A O    1 
HETATM 5928 O O    . HOH B 2 .   ? 29.43810  -5.65293  -37.79600 1.000 30.90061  ?  553 HOH A O    1 
HETATM 5929 O O    . HOH B 2 .   ? 14.78320  4.70825   -13.09953 1.000 33.12652  ?  554 HOH A O    1 
HETATM 5930 O O    . HOH B 2 .   ? 4.80989   -1.29217  -33.32290 1.000 28.22799  ?  555 HOH A O    1 
HETATM 5931 D D1   . HOH B 2 .   ? 4.68306   -1.47267  -32.40390 1.000 33.87359  ?  555 HOH A D1   1 
HETATM 5932 O O    . HOH B 2 .   ? 24.80032  -23.74960 -24.96268 1.000 30.23960  ?  556 HOH A O    1 
HETATM 5933 O O    . HOH B 2 .   ? 32.77887  -12.72401 -6.77386  1.000 18.76204  ?  557 HOH A O    1 
HETATM 5934 D D1   . HOH B 2 .   ? 32.97865  -13.30090 -6.03775  0.770 22.51445  ?  557 HOH A D1   1 
HETATM 5935 D D2   . HOH B 2 .   ? 33.26032  -13.06203 -7.53389  1.000 22.51445  ?  557 HOH A D2   1 
HETATM 5936 O O    . HOH B 2 .   ? 9.90059   -4.46406  -29.64171 1.000 16.20920  ?  558 HOH A O    1 
HETATM 5937 D D2   . HOH B 2 .   ? 10.56803  -3.99390  -30.13485 1.000 19.45104  ?  558 HOH A D2   1 
HETATM 5938 O O    . HOH B 2 .   ? 25.808    0.900     8.029     1.000 39.01193  ?  559 HOH A O    1 
HETATM 5939 O O    . HOH B 2 .   ? 8.55117   -5.30905  -13.91200 1.000 25.27720  ?  560 HOH A O    1 
HETATM 5940 O O    . HOH B 2 .   ? 17.31799  -2.15111  -31.69815 1.000 19.53840  ?  561 HOH A O    1 
HETATM 5941 D D1   . HOH B 2 .   ? 17.46802  -2.65548  -30.91808 0.320 23.44608  ?  561 HOH A D1   1 
HETATM 5942 D D2   . HOH B 2 .   ? 16.51248  -2.48698  -32.07362 1.000 23.44608  ?  561 HOH A D2   1 
HETATM 5943 O O    . HOH B 2 .   ? 20.92138  -13.95426 8.01497   1.000 35.75485  ?  562 HOH A O    1 
HETATM 5944 O O    . HOH B 2 .   ? 8.40311   -21.90230 2.61212   1.000 33.69756  ?  563 HOH A O    1 
HETATM 5945 O O    . HOH B 2 .   ? 21.06100  -7.24150  -19.49578 1.000 14.03367  ?  564 HOH A O    1 
HETATM 5946 D D1   . HOH B 2 .   ? 21.75814  -7.58539  -20.06171 0.590 16.84040  ?  564 HOH A D1   1 
HETATM 5947 D D2   . HOH B 2 .   ? 21.43442  -7.07401  -18.65285 1.000 16.84040  ?  564 HOH A D2   1 
HETATM 5948 O O    . HOH B 2 .   ? 25.34122  4.24286   -31.61915 1.000 19.88262  ?  565 HOH A O    1 
HETATM 5949 D D1   . HOH B 2 .   ? 25.76854  4.42450   -32.43414 1.000 23.85915  ?  565 HOH A D1   1 
HETATM 5950 D D2   . HOH B 2 .   ? 24.47681  3.94815   -31.85478 1.000 23.85915  ?  565 HOH A D2   1 
HETATM 5951 O O    . HOH B 2 .   ? 7.028     -18.958   1.924     1.000 21.35247  ?  566 HOH A O    1 
HETATM 5952 D D1   . HOH B 2 .   ? 6.770     -18.103   1.572     0.810 25.62297  ?  566 HOH A D1   1 
HETATM 5953 D D2   . HOH B 2 .   ? 6.984     -18.876   2.882     1.000 25.62297  ?  566 HOH A D2   1 
HETATM 5954 O O    . HOH B 2 .   ? 26.96138  -18.00599 -32.30180 1.000 24.67885  ?  567 HOH A O    1 
HETATM 5955 D D1   . HOH B 2 .   ? 27.74715  -18.49236 -32.12898 1.000 29.61462  ?  567 HOH A D1   1 
HETATM 5956 D D2   . HOH B 2 .   ? 27.10365  -17.09506 -32.05137 0.700 29.61462  ?  567 HOH A D2   1 
HETATM 5957 O O    . HOH B 2 .   ? 25.96563  -7.83246  -13.23286 1.000 22.14065  ?  568 HOH A O    1 
HETATM 5958 D D1   . HOH B 2 .   ? 25.33593  -8.48400  -12.97189 1.000 26.56878  ?  568 HOH A D1   1 
HETATM 5959 O O    . HOH B 2 .   ? 38.11526  -4.31031  -25.69078 1.000 21.01146  ?  569 HOH A O    1 
HETATM 5960 D D1   . HOH B 2 .   ? 38.42987  -3.41998  -25.51462 0.800 25.21375  ?  569 HOH A D1   1 
HETATM 5961 D D2   . HOH B 2 .   ? 37.86848  -4.41546  -26.60098 0.880 25.21375  ?  569 HOH A D2   1 
HETATM 5962 O O    . HOH B 2 .   ? 21.28084  -4.44513  -9.24952  1.000 13.77725  ?  570 HOH A O    1 
HETATM 5963 D D1   . HOH B 2 .   ? 21.01251  -4.55996  -10.16631 0.670 16.53270  ?  570 HOH A D1   1 
HETATM 5964 D D2   . HOH B 2 .   ? 21.03149  -5.23568  -8.74704  1.000 16.53270  ?  570 HOH A D2   1 
HETATM 5965 O O    . HOH B 2 .   ? 5.13626   -16.50885 -17.11278 1.000 17.03876  ?  571 HOH A O    1 
HETATM 5966 D D1   . HOH B 2 .   ? 4.92633   -16.82618 -17.98647 1.000 20.44652  ?  571 HOH A D1   1 
HETATM 5967 D D2   . HOH B 2 .   ? 4.31646   -16.48180 -16.62663 0.670 20.44652  ?  571 HOH A D2   1 
HETATM 5968 O O    . HOH B 2 .   ? 20.43838  5.73612   -8.40700  1.000 31.58017  ?  572 HOH A O    1 
HETATM 5969 O O    . HOH B 2 .   ? 30.86213  -21.53677 -24.06463 1.000 31.02327  ?  573 HOH A O    1 
HETATM 5970 O O    . HOH B 2 .   ? 8.81017   -32.34227 -7.86579  1.000 23.04855  ?  574 HOH A O    1 
HETATM 5971 D D1   . HOH B 2 .   ? 9.30667   -32.41175 -7.06109  1.000 27.65826  ?  574 HOH A D1   1 
HETATM 5972 D D2   . HOH B 2 .   ? 8.04216   -31.82202 -7.64578  0.900 27.65826  ?  574 HOH A D2   1 
HETATM 5973 O O    . HOH B 2 .   ? 30.21488  -21.71365 -2.93583  1.000 25.80855  ?  575 HOH A O    1 
HETATM 5974 D D1   . HOH B 2 .   ? 30.81306  -21.63725 -2.21036  0.730 30.97026  ?  575 HOH A D1   1 
HETATM 5975 O O    . HOH B 2 .   ? 1.77767   -17.08094 -3.00190  1.000 29.59394  ?  576 HOH A O    1 
HETATM 5976 D D1   . HOH B 2 .   ? 2.15068   -16.79240 -2.17101  1.000 35.51273  ?  576 HOH A D1   1 
HETATM 5977 O O    . HOH B 2 .   ? -8.83719  -13.59933 -18.72758 1.000 39.56815  ?  577 HOH A O    1 
HETATM 5978 O O    . HOH B 2 .   ? 19.65947  -0.45741  3.99247   1.000 22.16348  ?  578 HOH A O    1 
HETATM 5979 D D1   . HOH B 2 .   ? 20.24325  0.03720   4.52994   1.000 26.59617  ?  578 HOH A D1   1 
HETATM 5980 O O    . HOH B 2 .   ? 0.04245   -11.05224 -32.06625 1.000 27.48276  ?  579 HOH A O    1 
HETATM 5981 D D1   . HOH B 2 .   ? 0.66072   -10.88072 -32.77390 1.000 32.97931  ?  579 HOH A D1   1 
HETATM 5982 O O    . HOH B 2 .   ? 30.15093  -22.18583 -17.41929 1.000 33.39325  ?  580 HOH A O    1 
HETATM 5983 O O    . HOH B 2 .   ? 8.82450   -17.28614 -12.88011 1.000 22.88109  ?  581 HOH A O    1 
HETATM 5984 D D1   . HOH B 2 .   ? 9.62756   -17.62186 -12.49007 1.000 27.45731  ?  581 HOH A D1   1 
HETATM 5985 O O    . HOH B 2 .   ? 23.16106  -18.32492 3.06528   1.000 35.29921  ?  582 HOH A O    1 
HETATM 5986 D D2   . HOH B 2 .   ? 23.32742  -17.38754 3.01059   1.000 42.35905  ?  582 HOH A D2   1 
HETATM 5987 O O    . HOH B 2 .   ? 15.38955  3.22436   -34.39211 1.000 28.48471  ?  583 HOH A O    1 
HETATM 5988 D D1   . HOH B 2 .   ? 16.24987  3.55954   -34.19253 1.000 34.18165  ?  583 HOH A D1   1 
HETATM 5989 O O    . HOH B 2 .   ? 13.63314  -2.82406  -3.17249  1.000 23.58544  ?  584 HOH A O    1 
HETATM 5990 D D1   . HOH B 2 .   ? 14.22578  -3.56562  -3.16633  0.840 28.30253  ?  584 HOH A D1   1 
HETATM 5991 O O    . HOH B 2 .   ? 31.40795  -11.15591 -0.20777  1.000 17.75626  ?  585 HOH A O    1 
HETATM 5992 D D2   . HOH B 2 .   ? 30.59590  -10.90655 0.20199   0.700 21.30751  ?  585 HOH A D2   1 
HETATM 5993 O O    . HOH B 2 .   ? 1.99981   -20.83584 -5.96214  1.000 40.76993  ?  586 HOH A O    1 
HETATM 5994 O O    . HOH B 2 .   ? 6.13215   -24.30895 -19.10723 1.000 32.81193  ?  587 HOH A O    1 
HETATM 5995 O O    . HOH B 2 .   ? 19.97256  3.51808   -4.92397  1.000 30.69264  ?  588 HOH A O    1 
HETATM 5996 D D2   . HOH B 2 .   ? 19.58602  2.89938   -5.52623  0.790 36.83117  ?  588 HOH A D2   1 
HETATM 5997 O O    . HOH B 2 .   ? 19.57453  -30.07127 -17.73637 1.000 20.60556  ?  589 HOH A O    1 
HETATM 5998 D D1   . HOH B 2 .   ? 19.89198  -29.37754 -18.31934 0.860 24.72667  ?  589 HOH A D1   1 
HETATM 5999 D D2   . HOH B 2 .   ? 18.72737  -30.33734 -18.09630 1.000 24.72667  ?  589 HOH A D2   1 
HETATM 6000 O O    . HOH B 2 .   ? 17.42957  -0.95483  -40.27033 1.000 31.38705  ?  590 HOH A O    1 
HETATM 6001 O O    . HOH B 2 .   ? 6.95736   6.27933   -20.14112 1.000 20.53203  ?  591 HOH A O    1 
HETATM 6002 D D1   . HOH B 2 .   ? 7.39746   7.12151   -20.23318 1.000 24.63844  ?  591 HOH A D1   1 
HETATM 6003 D D2   . HOH B 2 .   ? 6.16567   6.28170   -20.67428 0.980 24.63844  ?  591 HOH A D2   1 
HETATM 6004 O O    . HOH B 2 .   ? 13.58344  -7.96807  -24.98083 1.000 14.65721  ?  592 HOH A O    1 
HETATM 6005 D D1   . HOH B 2 .   ? 13.58647  -7.05330  -24.75687 0.750 17.58866  ?  592 HOH A D1   1 
HETATM 6006 D D2   . HOH B 2 .   ? 13.82221  -7.99372  -25.91476 0.890 17.58866  ?  592 HOH A D2   1 
HETATM 6007 O O    . HOH B 2 .   ? 7.04032   -12.93387 -14.15648 1.000 18.45609  ?  593 HOH A O    1 
HETATM 6008 D D1   . HOH B 2 .   ? 7.45122   -12.09369 -14.29648 1.000 22.14731  ?  593 HOH A D1   1 
HETATM 6009 D D2   . HOH B 2 .   ? 7.01674   -13.36573 -15.00537 0.940 22.14731  ?  593 HOH A D2   1 
HETATM 6010 O O    . HOH B 2 .   ? 23.39542  8.68250   -10.05856 1.000 36.94932  ?  594 HOH A O    1 
HETATM 6011 D D1   . HOH B 2 .   ? 23.11615  7.78812   -9.91297  1.000 44.33918  ?  594 HOH A D1   1 
HETATM 6012 D D2   . HOH B 2 .   ? 24.18407  8.83709   -9.54276  0.720 44.33918  ?  594 HOH A D2   1 
HETATM 6013 O O    . HOH B 2 .   ? 18.08597  -2.19102  -2.64920  1.000 15.97022  ?  595 HOH A O    1 
HETATM 6014 D D1   . HOH B 2 .   ? 19.02798  -2.32405  -2.62703  0.770 19.16427  ?  595 HOH A D1   1 
HETATM 6015 D D2   . HOH B 2 .   ? 17.70955  -3.06361  -2.52820  1.000 19.16427  ?  595 HOH A D2   1 
HETATM 6016 O O    . HOH B 2 .   ? 11.29379  -11.45939 -33.23283 1.000 27.79431  ?  596 HOH A O    1 
HETATM 6017 D D2   . HOH B 2 .   ? 10.39398  -11.57923 -33.00009 1.000 33.35317  ?  596 HOH A D2   1 
HETATM 6018 O O    . HOH B 2 .   ? 19.524    6.381     8.715     1.000 37.18920  ?  597 HOH A O    1 
HETATM 6019 O O    . HOH B 2 .   ? 15.691    10.249    -27.504   1.000 34.90707  ?  598 HOH A O    1 
HETATM 6020 O O    . HOH B 2 .   ? 32.95596  -15.98122 -31.83758 1.000 32.26371  ?  599 HOH A O    1 
HETATM 6021 O O    . HOH B 2 .   ? 34.49465  -5.81136  -2.41440  1.000 28.62219  ?  600 HOH A O    1 
HETATM 6022 D D1   . HOH B 2 .   ? 34.85584  -6.46720  -2.99924  1.000 34.34662  ?  600 HOH A D1   1 
HETATM 6023 O O    . HOH B 2 .   ? 20.75705  4.57141   -1.92699  1.000 36.98509  ?  601 HOH A O    1 
HETATM 6024 O O    . HOH B 2 .   ? 29.35627  -2.05066  2.21158   1.000 24.19369  ?  602 HOH A O    1 
HETATM 6025 D D1   . HOH B 2 .   ? 29.83455  -2.63500  1.63931   1.000 29.03243  ?  602 HOH A D1   1 
HETATM 6026 O O    . HOH B 2 .   ? 13.81424  -21.83666 -21.86339 1.000 21.68527  ?  603 HOH A O    1 
HETATM 6027 D D1   . HOH B 2 .   ? 14.71116  -21.68667 -22.11067 1.000 26.02233  ?  603 HOH A D1   1 
HETATM 6028 O O    . HOH B 2 .   ? 16.79871  -3.31480  -37.30840 1.000 23.08965  ?  604 HOH A O    1 
HETATM 6029 O O    . HOH B 2 .   ? 14.09216  -30.79882 -22.70373 1.000 35.41294  ?  605 HOH A O    1 
HETATM 6030 O O    . HOH B 2 .   ? 13.05357  -26.36129 -19.99486 1.000 30.41468  ?  606 HOH A O    1 
HETATM 6031 O O    . HOH B 2 .   ? 12.75432  6.14013   -22.95452 1.000 25.88680  ?  607 HOH A O    1 
HETATM 6032 D D2   . HOH B 2 .   ? 12.01662  5.80818   -22.46907 1.000 31.06416  ?  607 HOH A D2   1 
HETATM 6033 O O    . HOH B 2 .   ? 7.40728   -18.61162 -15.59828 1.000 19.62990  ?  608 HOH A O    1 
HETATM 6034 D D1   . HOH B 2 .   ? 8.01257   -17.92268 -15.29636 1.000 23.55589  ?  608 HOH A D1   1 
HETATM 6035 D D2   . HOH B 2 .   ? 7.55929   -19.38486 -15.05682 0.720 23.55589  ?  608 HOH A D2   1 
HETATM 6036 O O    . HOH B 2 .   ? 27.74867  -20.64783 -32.50611 1.000 30.12127  ?  609 HOH A O    1 
HETATM 6037 O O    . HOH B 2 .   ? 39.31943  -19.14313 -7.54599  1.000 33.84513  ?  610 HOH A O    1 
HETATM 6038 O O    . HOH B 2 .   ? 14.92356  0.28347   -31.43148 1.000 17.94538  ?  611 HOH A O    1 
HETATM 6039 D D1   . HOH B 2 .   ? 14.62939  -0.59179  -31.60409 1.000 21.53446  ?  611 HOH A D1   1 
HETATM 6040 O O    . HOH B 2 .   ? 11.97152  -2.72415  -6.79232  1.000 34.93421  ?  612 HOH A O    1 
HETATM 6041 O O    . HOH B 2 .   ? 10.47591  -30.74266 -9.81075  1.000 22.98028  ?  613 HOH A O    1 
HETATM 6042 D D1   . HOH B 2 .   ? 11.30347  -30.76522 -9.33034  1.000 27.57634  ?  613 HOH A D1   1 
HETATM 6043 D D2   . HOH B 2 .   ? 9.73620   -30.92894 -9.23349  1.000 27.57634  ?  613 HOH A D2   1 
HETATM 6044 O O    . HOH B 2 .   ? 18.73086  -25.69984 -8.75497  1.000 17.81460  ?  614 HOH A O    1 
HETATM 6045 D D1   . HOH B 2 .   ? 19.66766  -25.59018 -8.68477  1.000 21.37752  ?  614 HOH A D1   1 
HETATM 6046 O O    . HOH B 2 .   ? -6.49407  -18.11116 -25.32661 1.000 37.70814  ?  615 HOH A O    1 
HETATM 6047 O O    . HOH B 2 .   ? 12.66657  -11.26980 -30.69656 1.000 20.25192  ?  616 HOH A O    1 
HETATM 6048 D D1   . HOH B 2 .   ? 13.60932  -11.39230 -30.71124 0.900 24.30230  ?  616 HOH A D1   1 
HETATM 6049 D D2   . HOH B 2 .   ? 12.43909  -10.83476 -31.50257 0.480 24.30230  ?  616 HOH A D2   1 
HETATM 6050 O O    . HOH B 2 .   ? 22.34003  -2.05176  -9.11943  1.000 15.04622  ?  617 HOH A O    1 
HETATM 6051 D D1   . HOH B 2 .   ? 21.82873  -2.80402  -8.87710  0.820 18.05546  ?  617 HOH A D1   1 
HETATM 6052 D D2   . HOH B 2 .   ? 22.24683  -1.97492  -10.06352 1.000 18.05546  ?  617 HOH A D2   1 
HETATM 6053 O O    . HOH B 2 .   ? 12.02391  3.70883   -13.18928 1.000 33.99945  ?  618 HOH A O    1 
HETATM 6054 O O    . HOH B 2 .   ? 16.06194  -26.03831 -5.09434  1.000 27.17152  ?  619 HOH A O    1 
HETATM 6055 D D2   . HOH B 2 .   ? 15.26558  -26.38763 -5.46590  1.000 32.60582  ?  619 HOH A D2   1 
HETATM 6056 O O    . HOH B 2 .   ? 9.50030   -19.94856 -12.94894 1.000 19.92126  ?  620 HOH A O    1 
HETATM 6057 D D1   . HOH B 2 .   ? 9.08303   -19.55118 -13.69707 0.920 23.90551  ?  620 HOH A D1   1 
HETATM 6058 O O    . HOH B 2 .   ? 11.60979  -17.14533 -19.95916 1.000 12.96973  ?  621 HOH A O    1 
HETATM 6059 D D1   . HOH B 2 .   ? 11.56815  -17.94377 -20.48348 0.850 15.56368  ?  621 HOH A D1   1 
HETATM 6060 D D2   . HOH B 2 .   ? 10.75845  -16.74138 -20.04189 0.680 15.56368  ?  621 HOH A D2   1 
HETATM 6061 O O    . HOH B 2 .   ? 31.88824  -21.92941 -14.00098 1.000 20.50662  ?  622 HOH A O    1 
HETATM 6062 D D1   . HOH B 2 .   ? 31.15981  -21.46548 -14.41287 0.900 24.60794  ?  622 HOH A D1   1 
HETATM 6063 D D2   . HOH B 2 .   ? 31.70798  -21.89749 -13.06606 0.650 24.60794  ?  622 HOH A D2   1 
HETATM 6064 O O    . HOH B 2 .   ? 3.21161   8.48614   -10.98169 1.000 39.50202  ?  623 HOH A O    1 
HETATM 6065 O O    . HOH B 2 .   ? 8.20992   -20.87805 -24.82343 1.000 30.03567  ?  624 HOH A O    1 
HETATM 6066 O O    . HOH B 2 .   ? 15.17316  0.86038   -9.37468  1.000 31.46603  ?  625 HOH A O    1 
HETATM 6067 D D1   . HOH B 2 .   ? 16.03028  0.84174   -8.95144  1.000 37.75923  ?  625 HOH A D1   1 
HETATM 6068 O O    . HOH B 2 .   ? 21.38144  -4.39640  -17.05739 1.000 20.35899  ?  626 HOH A O    1 
HETATM 6069 D D1   . HOH B 2 .   ? 20.77228  -5.12029  -17.02615 0.590 24.43078  ?  626 HOH A D1   1 
HETATM 6070 D D2   . HOH B 2 .   ? 22.22636  -4.75601  -17.31499 1.000 24.43078  ?  626 HOH A D2   1 
HETATM 6071 O O    . HOH B 2 .   ? 29.47838  -24.45520 -15.92615 1.000 28.45459  ?  627 HOH A O    1 
HETATM 6072 O O    . HOH B 2 .   ? 21.39707  -28.24196 -8.93625  1.000 22.49219  ?  628 HOH A O    1 
HETATM 6073 D D1   . HOH B 2 .   ? 21.89552  -28.62464 -8.22960  0.770 26.99062  ?  628 HOH A D1   1 
HETATM 6074 D D2   . HOH B 2 .   ? 21.61577  -27.31716 -8.97273  1.000 26.99062  ?  628 HOH A D2   1 
HETATM 6075 O O    . HOH B 2 .   ? 29.523    -26.665   -27.528   1.000 38.76289  ?  629 HOH A O    1 
HETATM 6076 O O    . HOH B 2 .   ? 39.57398  -1.55343  -24.77192 1.000 29.72579  ?  630 HOH A O    1 
HETATM 6077 D D2   . HOH B 2 .   ? 38.79575  -1.13581  -24.42767 1.000 35.67095  ?  630 HOH A D2   1 
HETATM 6078 O O    . HOH B 2 .   ? 4.13797   -1.72188  -26.61271 1.000 20.15936  ?  631 HOH A O    1 
HETATM 6079 D D1   . HOH B 2 .   ? 4.83938   -2.21176  -27.04445 1.000 24.19123  ?  631 HOH A D1   1 
HETATM 6080 D D2   . HOH B 2 .   ? 4.43538   -1.47930  -25.73788 0.720 24.19123  ?  631 HOH A D2   1 
HETATM 6081 O O    . HOH B 2 .   ? 16.04250  -24.03296 5.11077   1.000 34.11980  ?  632 HOH A O    1 
HETATM 6082 O O    . HOH B 2 .   ? 5.94284   -10.83063 -12.74576 1.000 20.61186  ?  633 HOH A O    1 
HETATM 6083 D D2   . HOH B 2 .   ? 5.32174   -10.13888 -12.94731 1.000 24.73423  ?  633 HOH A D2   1 
HETATM 6084 O O    . HOH B 2 .   ? -3.28575  -6.77205  -14.99601 1.000 27.80011  ?  634 HOH A O    1 
HETATM 6085 D D2   . HOH B 2 .   ? -3.18552  -7.30116  -15.77615 1.000 33.36013  ?  634 HOH A D2   1 
HETATM 6086 O O    . HOH B 2 .   ? 10.50029  -19.58811 -29.87146 1.000 22.48918  ?  635 HOH A O    1 
HETATM 6087 D D1   . HOH B 2 .   ? 10.78560  -19.11146 -29.11279 0.830 26.98701  ?  635 HOH A D1   1 
HETATM 6088 O O    . HOH B 2 .   ? 33.22285  1.09343   -32.24022 1.000 26.71449  ?  636 HOH A O    1 
HETATM 6089 O O    . HOH B 2 .   ? 10.65616  -33.13757 -16.90938 1.000 28.63705  ?  637 HOH A O    1 
HETATM 6090 O O    . HOH B 2 .   ? 20.49285  -3.46211  -34.92721 1.000 18.52330  ?  638 HOH A O    1 
HETATM 6091 D D1   . HOH B 2 .   ? 21.11780  -3.62546  -34.22437 0.930 22.22796  ?  638 HOH A D1   1 
HETATM 6092 D D2   . HOH B 2 .   ? 19.72511  -3.98935  -34.77561 1.000 22.22796  ?  638 HOH A D2   1 
HETATM 6093 O O    . HOH B 2 .   ? 14.04495  -9.01454  -33.06870 1.000 37.30605  ?  639 HOH A O    1 
HETATM 6094 O O    . HOH B 2 .   ? 17.82122  -4.40243  -34.92782 1.000 21.84438  ?  640 HOH A O    1 
HETATM 6095 D D2   . HOH B 2 .   ? 17.35037  -3.91412  -34.28601 1.000 26.21326  ?  640 HOH A D2   1 
HETATM 6096 O O    . HOH B 2 .   ? 12.55073  -19.64593 -20.38071 1.000 16.86641  ?  641 HOH A O    1 
HETATM 6097 D D1   . HOH B 2 .   ? 12.93868  -20.43617 -20.71364 0.820 20.23969  ?  641 HOH A D1   1 
HETATM 6098 D D2   . HOH B 2 .   ? 13.04062  -19.36569 -19.59242 1.000 20.23969  ?  641 HOH A D2   1 
HETATM 6099 O O    . HOH B 2 .   ? 25.61335  -24.96290 -21.26838 1.000 23.91424  ?  642 HOH A O    1 
HETATM 6100 D D2   . HOH B 2 .   ? 24.96680  -25.57281 -21.59956 1.000 28.69709  ?  642 HOH A D2   1 
HETATM 6101 O O    . HOH B 2 .   ? 12.39932  -6.13434  -22.09983 1.000 13.18448  ?  643 HOH A O    1 
HETATM 6102 D D1   . HOH B 2 .   ? 13.09291  -5.92730  -22.73291 1.000 15.82138  ?  643 HOH A D1   1 
HETATM 6103 D D2   . HOH B 2 .   ? 12.25409  -7.07323  -22.03352 1.000 15.82138  ?  643 HOH A D2   1 
HETATM 6104 O O    . HOH B 2 .   ? 11.41882  -8.74597  -21.83698 1.000 13.77426  ?  644 HOH A O    1 
HETATM 6105 D D1   . HOH B 2 .   ? 12.14733  -9.35933  -21.88303 0.960 16.52912  ?  644 HOH A D1   1 
HETATM 6106 D D2   . HOH B 2 .   ? 10.88639  -8.93141  -21.08142 1.000 16.52912  ?  644 HOH A D2   1 
HETATM 6107 O O    . HOH B 2 .   ? 6.39904   -3.53724  -19.97491 1.000 16.61661  ?  645 HOH A O    1 
HETATM 6108 D D1   . HOH B 2 .   ? 6.12133   -3.83462  -19.10457 0.660 19.93993  ?  645 HOH A D1   1 
HETATM 6109 D D2   . HOH B 2 .   ? 6.17826   -2.61005  -20.00613 1.000 19.93993  ?  645 HOH A D2   1 
HETATM 6110 O O    . HOH B 2 .   ? 4.94524   -29.03097 -2.08333  1.000 26.09971  ?  646 HOH A O    1 
HETATM 6111 O O    . HOH B 2 .   ? 7.87833   -10.03137 -21.83443 1.000 26.74089  ?  647 HOH A O    1 
HETATM 6112 D D1   . HOH B 2 .   ? 8.41731   -10.01720 -21.04676 1.000 32.08907  ?  647 HOH A D1   1 
HETATM 6113 O O    . HOH B 2 .   ? 1.35310   9.04140   -14.99076 1.000 37.57221  ?  648 HOH A O    1 
HETATM 6114 D D2   . HOH B 2 .   ? 1.20255   8.11228   -14.85825 1.000 45.08665  ?  648 HOH A D2   1 
HETATM 6115 O O    . HOH B 2 .   ? -2.84741  0.05490   -16.59521 1.000 32.98387  ?  649 HOH A O    1 
HETATM 6116 D D1   . HOH B 2 .   ? -3.65950  -0.05650  -16.11805 0.760 39.58064  ?  649 HOH A D1   1 
HETATM 6117 O O    . HOH B 2 .   ? 10.46492  -16.40963 4.12741   1.000 31.84464  ?  650 HOH A O    1 
HETATM 6118 O O    . HOH B 2 .   ? 1.05788   -27.49647 -7.65448  1.000 27.07939  ?  651 HOH A O    1 
HETATM 6119 O O    . HOH B 2 .   ? 18.84789  -29.07148 -10.16263 1.000 28.42272  ?  652 HOH A O    1 
HETATM 6120 D D1   . HOH B 2 .   ? 18.98540  -28.26066 -9.69769  1.000 34.10727  ?  652 HOH A D1   1 
HETATM 6121 O O    . HOH B 2 .   ? 25.07232  -5.49152  -14.65803 1.000 12.60221  ?  653 HOH A O    1 
HETATM 6122 D D1   . HOH B 2 .   ? 25.10708  -6.25191  -14.11017 0.650 15.12265  ?  653 HOH A D1   1 
HETATM 6123 D D2   . HOH B 2 .   ? 24.58854  -5.71693  -15.46009 1.000 15.12265  ?  653 HOH A D2   1 
HETATM 6124 O O    . HOH B 2 .   ? 21.95806  6.04447   -30.50631 1.000 21.98448  ?  654 HOH A O    1 
HETATM 6125 O O    . HOH B 2 .   ? 3.30412   -21.63761 -24.36297 1.000 42.59399  ?  655 HOH A O    1 
HETATM 6126 O O    . HOH B 2 .   ? 32.04387  7.07389   -16.29446 1.000 26.07012  ?  656 HOH A O    1 
HETATM 6127 D D1   . HOH B 2 .   ? 32.38099  6.43617   -16.92049 1.000 31.28415  ?  656 HOH A D1   1 
HETATM 6128 D D2   . HOH B 2 .   ? 31.19721  7.38118   -16.61911 1.000 31.28415  ?  656 HOH A D2   1 
HETATM 6129 O O    . HOH B 2 .   ? 28.38150  1.29829   -37.66134 1.000 38.79026  ?  657 HOH A O    1 
HETATM 6130 D D1   . HOH B 2 .   ? 28.22168  1.63977   -38.53385 0.710 46.54832  ?  657 HOH A D1   1 
HETATM 6131 O O    . HOH B 2 .   ? 2.61750   -16.87491 -16.34620 1.000 21.29257  ?  658 HOH A O    1 
HETATM 6132 D D1   . HOH B 2 .   ? 2.48355   -17.17428 -15.44944 0.740 25.55109  ?  658 HOH A D1   1 
HETATM 6133 D D2   . HOH B 2 .   ? 2.32148   -17.54286 -16.95377 0.940 25.55109  ?  658 HOH A D2   1 
HETATM 6134 O O    . HOH B 2 .   ? 13.33342  -17.48565 4.31047   1.000 23.63082  ?  659 HOH A O    1 
HETATM 6135 O O    . HOH B 2 .   ? -2.99751  1.87099   -19.73114 1.000 29.06470  ?  660 HOH A O    1 
HETATM 6136 D D1   . HOH B 2 .   ? -2.43859  2.62506   -19.82789 1.000 34.87764  ?  660 HOH A D1   1 
HETATM 6137 D D2   . HOH B 2 .   ? -3.88894  2.14783   -19.92884 0.610 34.87764  ?  660 HOH A D2   1 
HETATM 6138 O O    . HOH B 2 .   ? 16.60799  15.75660  -17.87791 1.000 40.87438  ?  661 HOH A O    1 
HETATM 6139 O O    . HOH B 2 .   ? 18.09165  -27.23212 -27.96376 1.000 45.02407  ?  662 HOH A O    1 
HETATM 6140 O O    . HOH B 2 .   ? 32.87601  -9.95198  -6.75277  1.000 30.56245  ?  663 HOH A O    1 
HETATM 6141 D D1   . HOH B 2 .   ? 33.41502  -10.56277 -6.27570  1.000 36.67494  ?  663 HOH A D1   1 
HETATM 6142 O O    . HOH B 2 .   ? 8.21058   -10.41724 -11.09520 1.000 19.63175  ?  664 HOH A O    1 
HETATM 6143 D D1   . HOH B 2 .   ? 8.27905   -9.47816  -11.23206 0.920 23.55810  ?  664 HOH A D1   1 
HETATM 6144 D D2   . HOH B 2 .   ? 7.43922   -10.68420 -11.58042 0.730 23.55810  ?  664 HOH A D2   1 
HETATM 6145 O O    . HOH B 2 .   ? 29.31827  -23.59760 -25.19657 1.000 39.01796  ?  665 HOH A O    1 
HETATM 6146 O O    . HOH B 2 .   ? 33.70347  3.26767   -24.29883 1.000 25.34497  ?  666 HOH A O    1 
HETATM 6147 D D1   . HOH B 2 .   ? 33.32020  3.30155   -23.43058 0.660 30.41396  ?  666 HOH A D1   1 
HETATM 6148 D D2   . HOH B 2 .   ? 33.57542  2.37287   -24.59803 0.680 30.41396  ?  666 HOH A D2   1 
HETATM 6149 O O    . HOH B 2 .   ? 21.38539  1.21067   -21.92600 1.000 38.80225  ?  667 HOH A O    1 
HETATM 6150 O O    . HOH B 2 .   ? 26.44514  10.33248  -8.24327  1.000 28.90027  ?  668 HOH A O    1 
HETATM 6151 D D1   . HOH B 2 .   ? 26.97868  10.98021  -8.68951  1.000 34.68033  ?  668 HOH A D1   1 
HETATM 6152 D D2   . HOH B 2 .   ? 25.54076  10.53781  -8.42535  0.850 34.68033  ?  668 HOH A D2   1 
HETATM 6153 O O    . HOH B 2 .   ? 18.35436  -25.69812 -6.15249  1.000 34.60515  ?  669 HOH A O    1 
HETATM 6154 D D2   . HOH B 2 .   ? 17.51824  -26.06343 -5.88149  1.000 41.52618  ?  669 HOH A D2   1 
HETATM 6155 O O    . HOH B 2 .   ? 24.04269  3.73808   -17.64378 1.000 41.96233  ?  670 HOH A O    1 
HETATM 6156 O O    . HOH B 2 .   ? 22.57546  2.36265   -13.12771 1.000 22.89249  ?  671 HOH A O    1 
HETATM 6157 D D1   . HOH B 2 .   ? 23.32474  2.11610   -13.67759 1.000 27.47098  ?  671 HOH A D1   1 
HETATM 6158 D D2   . HOH B 2 .   ? 21.76609  2.07584   -13.52720 1.000 27.47098  ?  671 HOH A D2   1 
HETATM 6159 O O    . HOH B 2 .   ? 23.22365  3.37627   9.66489   1.000 37.36420  ?  672 HOH A O    1 
HETATM 6160 D D2   . HOH B 2 .   ? 24.14886  3.16881   9.56269   1.000 44.83704  ?  672 HOH A D2   1 
HETATM 6161 O O    . HOH B 2 .   ? 17.20157  -8.17038  4.87713   1.000 26.90097  ?  673 HOH A O    1 
HETATM 6162 D D1   . HOH B 2 .   ? 17.94614  -8.68741  5.13004   0.890 32.28116  ?  673 HOH A D1   1 
HETATM 6163 D D2   . HOH B 2 .   ? 17.44675  -7.66092  4.11294   0.710 32.28116  ?  673 HOH A D2   1 
HETATM 6164 O O    . HOH B 2 .   ? 37.56144  -3.91283  -15.78827 1.000 31.65696  ?  674 HOH A O    1 
HETATM 6165 D D1   . HOH B 2 .   ? 37.99124  -4.47549  -15.15269 0.970 37.98836  ?  674 HOH A D1   1 
HETATM 6166 D D2   . HOH B 2 .   ? 37.50051  -4.38903  -16.60393 1.000 37.98836  ?  674 HOH A D2   1 
HETATM 6167 O O    . HOH B 2 .   ? 1.70027   -33.51034 -5.78402  1.000 34.21317  ?  675 HOH A O    1 
HETATM 6168 O O    . HOH B 2 .   ? 4.46866   15.58295  -16.21408 1.000 44.99587  ?  676 HOH A O    1 
HETATM 6169 O O    . HOH B 2 .   ? -0.67012  -3.13062  -11.13002 1.000 35.36240  ?  677 HOH A O    1 
HETATM 6170 D D2   . HOH B 2 .   ? -0.28129  -2.77622  -10.34100 1.000 42.43488  ?  677 HOH A D2   1 
HETATM 6171 O O    . HOH B 2 .   ? 9.38212   -34.31161 -9.48681  1.000 41.06553  ?  678 HOH A O    1 
HETATM 6172 O O    . HOH B 2 .   ? 29.33136  12.13341  -10.50284 1.000 28.35174  ?  679 HOH A O    1 
HETATM 6173 D D1   . HOH B 2 .   ? 30.23007  12.33806  -10.74521 0.930 34.02209  ?  679 HOH A D1   1 
HETATM 6174 O O    . HOH B 2 .   ? 33.85054  1.60247   -3.73984  1.000 23.62574  ?  680 HOH A O    1 
HETATM 6175 D D2   . HOH B 2 .   ? 33.35076  2.34880   -4.03520  1.000 28.35089  ?  680 HOH A D2   1 
HETATM 6176 O O    . HOH B 2 .   ? 24.27426  5.04850   0.65690   1.000 25.68628  ?  681 HOH A O    1 
HETATM 6177 O O    . HOH B 2 .   ? 25.93218  -0.47785  -36.61363 1.000 26.64577  ?  682 HOH A O    1 
HETATM 6178 D D2   . HOH B 2 .   ? 25.67003  -1.12557  -35.98686 0.810 31.97493  ?  682 HOH A D2   1 
HETATM 6179 O O    . HOH B 2 .   ? 18.57151  -4.50736  -16.99270 1.000 23.00125  ?  683 HOH A O    1 
HETATM 6180 D D2   . HOH B 2 .   ? 18.08805  -4.85972  -17.73054 1.000 27.60150  ?  683 HOH A D2   1 
HETATM 6181 O O    . HOH B 2 .   ? 26.86042  -1.34051  3.47000   1.000 23.70212  ?  684 HOH A O    1 
HETATM 6182 D D1   . HOH B 2 .   ? 27.55139  -1.40403  4.12239   1.000 28.44254  ?  684 HOH A D1   1 
HETATM 6183 O O    . HOH B 2 .   ? 13.79162  -2.19155  -30.65459 1.000 17.18638  ?  685 HOH A O    1 
HETATM 6184 D D1   . HOH B 2 .   ? 13.12496  -2.69207  -31.12834 0.920 20.62366  ?  685 HOH A D1   1 
HETATM 6185 D D2   . HOH B 2 .   ? 14.41465  -2.81083  -30.29945 0.720 20.62366  ?  685 HOH A D2   1 
HETATM 6186 O O    . HOH B 2 .   ? 24.39094  -21.18229 1.28341   1.000 31.92385  ?  686 HOH A O    1 
HETATM 6187 O O    . HOH B 2 .   ? 8.36577   -25.88225 -20.14341 1.000 28.87034  ?  687 HOH A O    1 
HETATM 6188 O O    . HOH B 2 .   ? -0.41531  -20.02586 -16.55221 1.000 33.68368  ?  688 HOH A O    1 
HETATM 6189 O O    . HOH B 2 .   ? 27.49992  -26.93030 -15.10776 1.000 35.31126  ?  689 HOH A O    1 
HETATM 6190 O O    . HOH B 2 .   ? 3.55909   1.06436   -26.84747 1.000 24.97350  ?  690 HOH A O    1 
HETATM 6191 D D2   . HOH B 2 .   ? 3.69828   0.12972   -26.86016 1.000 29.96820  ?  690 HOH A D2   1 
HETATM 6192 O O    . HOH B 2 .   ? 30.87313  -10.42852 -33.42316 1.000 24.46703  ?  691 HOH A O    1 
HETATM 6193 D D2   . HOH B 2 .   ? 30.57686  -10.43010 -32.53037 0.890 29.36044  ?  691 HOH A D2   1 
HETATM 6194 O O    . HOH B 2 .   ? 33.98722  9.20769   -9.74430  1.000 38.96745  ?  692 HOH A O    1 
HETATM 6195 O O    . HOH B 2 .   ? 16.99184  -28.36302 -24.37965 1.000 40.00757  ?  693 HOH A O    1 
HETATM 6196 O O    . HOH B 2 .   ? 0.89023   4.49442   -10.77636 1.000 36.23050  ?  694 HOH A O    1 
HETATM 6197 D D2   . HOH B 2 .   ? 0.98070   4.53789   -9.83590  0.980 43.47660  ?  694 HOH A D2   1 
HETATM 6198 O O    . HOH B 2 .   ? 28.52035  -8.16095  -39.47175 1.000 42.19607  ?  695 HOH A O    1 
HETATM 6199 O O    . HOH B 2 .   ? 2.43108   7.73834   -25.87990 1.000 38.07174  ?  696 HOH A O    1 
HETATM 6200 O O    . HOH B 2 .   ? 3.47347   -24.28912 -14.57468 1.000 23.65117  ?  697 HOH A O    1 
HETATM 6201 D D1   . HOH B 2 .   ? 3.08504   -24.31467 -13.71585 1.000 28.38141  ?  697 HOH A D1   1 
HETATM 6202 O O    . HOH B 2 .   ? -3.00357  -0.38497  -26.94850 1.000 34.17599  ?  698 HOH A O    1 
HETATM 6203 D D1   . HOH B 2 .   ? -2.86843  -0.78349  -27.81126 1.000 41.01119  ?  698 HOH A D1   1 
HETATM 6204 O O    . HOH B 2 .   ? 33.99164  3.81253   -16.04731 1.000 26.33480  ?  699 HOH A O    1 
HETATM 6205 D D1   . HOH B 2 .   ? 34.44798  2.97485   -15.97122 1.000 31.60176  ?  699 HOH A D1   1 
HETATM 6206 D D2   . HOH B 2 .   ? 33.61019  3.85211   -16.91064 0.920 31.60176  ?  699 HOH A D2   1 
HETATM 6207 O O    . HOH B 2 .   ? 26.46907  -3.29972  6.11426   1.000 23.73353  ?  700 HOH A O    1 
HETATM 6208 D D1   . HOH B 2 .   ? 26.87175  -2.44932  5.94141   1.000 28.48024  ?  700 HOH A D1   1 
HETATM 6209 O O    . HOH B 2 .   ? 20.11888  -4.96677  -20.57820 1.000 22.98685  ?  701 HOH A O    1 
HETATM 6210 D D1   . HOH B 2 .   ? 20.60636  -4.54166  -19.85708 1.000 27.58422  ?  701 HOH A D1   1 
HETATM 6211 D D2   . HOH B 2 .   ? 19.19059  -4.90992  -20.36093 0.880 27.58422  ?  701 HOH A D2   1 
HETATM 6212 O O    . HOH B 2 .   ? 23.767    -24.068   -27.396   1.000 26.97475  ?  702 HOH A O    1 
HETATM 6213 D D2   . HOH B 2 .   ? 23.817    -23.380   -28.050   0.820 32.36969  ?  702 HOH A D2   1 
HETATM 6214 O O    . HOH B 2 .   ? 10.88537  -5.15350  -36.61006 1.000 33.02786  ?  703 HOH A O    1 
HETATM 6215 O O    . HOH B 2 .   ? 0.65706   -20.04388 -25.16221 1.000 42.15116  ?  704 HOH A O    1 
HETATM 6216 O O    . HOH B 2 .   ? 28.76161  6.44221   -32.55944 1.000 26.16138  ?  705 HOH A O    1 
HETATM 6217 O O    . HOH B 2 .   ? 12.72601  -2.66327  3.69304   1.000 45.47134  ?  706 HOH A O    1 
HETATM 6218 O O    . HOH B 2 .   ? 5.98520   -12.48761 -6.51493  1.000 39.73029  ?  707 HOH A O    1 
HETATM 6219 O O    . HOH B 2 .   ? 19.45887  -4.36662  -31.73556 1.000 19.61325  ?  708 HOH A O    1 
HETATM 6220 D D1   . HOH B 2 .   ? 20.24464  -4.57185  -32.22492 0.900 23.53590  ?  708 HOH A D1   1 
HETATM 6221 D D2   . HOH B 2 .   ? 19.56087  -3.50699  -31.37419 1.000 23.53590  ?  708 HOH A D2   1 
HETATM 6222 O O    . HOH B 2 .   ? 18.66321  7.95060   -22.82566 1.000 41.04664  ?  709 HOH A O    1 
HETATM 6223 O O    . HOH B 2 .   ? 12.95434  -25.15134 -25.64352 1.000 30.76704  ?  710 HOH A O    1 
HETATM 6224 O O    . HOH B 2 .   ? 27.26786  7.68324   -2.80727  1.000 34.91137  ?  711 HOH A O    1 
HETATM 6225 O O    . HOH B 2 .   ? 9.08788   -17.56402 -31.36431 1.000 24.74174  ?  712 HOH A O    1 
HETATM 6226 D D1   . HOH B 2 .   ? 8.38098   -18.07746 -31.03012 1.000 29.69009  ?  712 HOH A D1   1 
HETATM 6227 O O    . HOH B 2 .   ? 34.52318  0.78762   -29.62658 1.000 25.66818  ?  713 HOH A O    1 
HETATM 6228 D D2   . HOH B 2 .   ? 34.20810  1.39319   -28.96985 1.000 30.80181  ?  713 HOH A D2   1 
HETATM 6229 O O    . HOH B 2 .   ? 29.23465  -12.20547 -35.19846 1.000 36.46180  ?  714 HOH A O    1 
HETATM 6230 O O    . HOH B 2 .   ? -1.25475  -10.74893 -10.16925 1.000 37.86958  ?  715 HOH A O    1 
HETATM 6231 O O    . HOH B 2 .   ? 35.05049  1.13555   -20.46852 1.000 32.45399  ?  716 HOH A O    1 
HETATM 6232 O O    . HOH B 2 .   ? 22.40457  6.91232   -26.27027 1.000 34.32425  ?  717 HOH A O    1 
HETATM 6233 O O    . HOH B 2 .   ? 15.94419  -11.20893 -33.12077 1.000 24.77918  ?  718 HOH A O    1 
HETATM 6234 O O    . HOH B 2 .   ? 22.31318  -26.45231 -25.54877 1.000 34.99385  ?  719 HOH A O    1 
HETATM 6235 O O    . HOH B 2 .   ? 25.49253  -0.24770  12.39620  1.000 36.46227  ?  720 HOH A O    1 
HETATM 6236 O O    . HOH B 2 .   ? -0.10740  -30.07987 -8.36328  1.000 35.36801  ?  721 HOH A O    1 
HETATM 6237 O O    . HOH B 2 .   ? 23.40464  6.95849   -2.41267  1.000 42.79775  ?  722 HOH A O    1 
HETATM 6238 O O    . HOH B 2 .   ? 12.87847  1.20391   -40.62063 1.000 42.21938  ?  723 HOH A O    1 
HETATM 6239 O O    . HOH B 2 .   ? 40.56848  -10.97008 -14.72473 1.000 39.74555  ?  724 HOH A O    1 
HETATM 6240 O O    . HOH B 2 .   ? 1.81277   11.48136  -16.47755 1.000 44.14122  ?  725 HOH A O    1 
HETATM 6241 O O    . HOH B 2 .   ? 34.08656  -10.50622 -1.30049  1.000 27.15375  ?  726 HOH A O    1 
HETATM 6242 O O    . HOH B 2 .   ? 34.15635  -6.64991  -31.68291 1.000 28.55425  ?  727 HOH A O    1 
HETATM 6243 D D2   . HOH B 2 .   ? 33.53998  -6.30517  -32.30747 1.000 34.26510  ?  727 HOH A D2   1 
HETATM 6244 O O    . HOH B 2 .   ? 18.32203  -2.41242  -19.88801 1.000 34.00702  ?  728 HOH A O    1 
HETATM 6245 O O    . HOH B 2 .   ? 37.32952  -22.27427 -21.59619 1.000 31.69022  ?  729 HOH A O    1 
HETATM 6246 D D1   . HOH B 2 .   ? 37.79238  -21.47959 -21.83314 0.940 38.02826  ?  729 HOH A D1   1 
HETATM 6247 O O    . HOH B 2 .   ? -9.36287  -3.02320  -25.97596 1.000 34.87534  ?  730 HOH A O    1 
HETATM 6248 O O    . HOH B 2 .   ? -4.96585  -16.00597 -18.93142 1.000 40.14972  ?  731 HOH A O    1 
HETATM 6249 D D1   . HOH B 2 .   ? -4.44958  -16.30141 -19.66627 1.000 48.17967  ?  731 HOH A D1   1 
HETATM 6250 O O    . HOH B 2 .   ? 23.62120  7.63718   -28.92152 1.000 31.93141  ?  732 HOH A O    1 
HETATM 6251 O O    . HOH B 2 .   ? 16.89463  -0.17743  4.91607   1.000 36.78359  ?  733 HOH A O    1 
HETATM 6252 O O    . HOH B 2 .   ? 1.15803   1.90411   -25.59487 1.000 37.22675  ?  734 HOH A O    1 
HETATM 6253 O O    . HOH B 2 .   ? 0.18090   -20.21327 -13.73725 1.000 40.47256  ?  735 HOH A O    1 
HETATM 6254 O O    . HOH B 2 .   ? 8.29880   -3.87789  -0.57119  1.000 39.11494  ?  736 HOH A O    1 
HETATM 6255 O O    . HOH B 2 .   ? 25.57862  -17.76424 -34.14840 1.000 40.67724  ?  737 HOH A O    1 
HETATM 6256 O O    . HOH B 2 .   ? 9.04771   -21.82536 -28.81379 1.000 44.87708  ?  738 HOH A O    1 
HETATM 6257 O O    . HOH B 2 .   ? 34.62937  -8.54213  -3.35717  1.000 34.50551  ?  739 HOH A O    1 
HETATM 6258 O O    . HOH B 2 .   ? 16.62011  -1.15712  -18.90613 1.000 49.23814  ?  740 HOH A O    1 
HETATM 6259 O O    . HOH B 2 .   ? 29.53978  -24.38125 -3.58477  1.000 37.45575  ?  741 HOH A O    1 
HETATM 6260 O O    . HOH B 2 .   ? 37.15227  0.39539   -30.57171 1.000 34.08543  ?  742 HOH A O    1 
HETATM 6261 O O    . HOH B 2 .   ? 5.81033   -11.96730 -9.23023  1.000 49.45698  ?  743 HOH A O    1 
HETATM 6262 O O    . HOH B 2 .   ? 12.33624  -23.48651 -23.05312 1.000 35.91992  ?  744 HOH A O    1 
HETATM 6263 O O    . HOH B 2 .   ? 8.47790   -23.06754 -23.04749 1.000 48.00853  ?  745 HOH A O    1 
HETATM 6264 O O    . HOH B 2 .   ? 20.96162  -3.02423  -19.36769 1.000 34.78834  ?  746 HOH A O    1 
HETATM 6265 O O    . HOH B 2 .   ? 30.927    -0.477    3.641     1.000 33.84630  ?  747 HOH A O    1 
HETATM 6266 O O    . HOH B 2 .   ? 25.54860  5.67531   -29.28486 1.000 28.00513  ?  748 HOH A O    1 
HETATM 6267 D D2   . HOH B 2 .   ? 25.12732  5.23849   -30.00850 1.000 33.60616  ?  748 HOH A D2   1 
HETATM 6268 O O    . HOH B 2 .   ? -3.36413  -6.81022  -12.36392 1.000 38.13092  ?  749 HOH A O    1 
HETATM 6269 O O    . HOH B 2 .   ? 15.39746  -6.43512  5.66504   1.000 34.62006  ?  750 HOH A O    1 
# 
