data_8W3Q
# 
_entry.id   8W3Q 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W3Q         pdb_00008w3q 10.2210/pdb8w3q/pdb 
WWPDB D_1000280352 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W3Q 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jiang@scripps.edu 
_pdbx_contact_author.name_first         JIANG 
_pdbx_contact_author.name_last          ZHU 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0259-7157 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lee, Y.Z.'       1 ? 
'Stanfield, R.L.' 2 ? 
'Wilson, I.A.'    3 ? 
'Zhu, J.'         4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9939 
_citation.page_last                 9939 
_citation.title                     
'Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54287-x 
_citation.pdbx_database_id_PubMed   39550381 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lee, Y.Z.'       1  0000-0002-5651-863X 
primary 'Han, J.'         2  ?                   
primary 'Zhang, Y.N.'     3  0000-0001-9053-5890 
primary 'Ward, G.'        4  ?                   
primary 'Braz Gomes, K.'  5  ?                   
primary 'Auclair, S.'     6  ?                   
primary 'Stanfield, R.L.' 7  ?                   
primary 'He, L.'          8  ?                   
primary 'Wilson, I.A.'    9  0000-0002-6469-2419 
primary 'Zhu, J.'         10 0000-0003-0259-7157 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'prefusion-stabilized hMPV F protein UFCM1-P2-iSS' 
_entity.formula_weight             55750.441 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSWKVVIIFSLLITPQHGLKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRD
LRTVSADGHGHPGGGGGGFVLGAIALGVATAAAVTCGVAIAKCIRLESEVTAIKNALKKTNEAVSTLGCGPRVLATAVRE
LKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISLDLMTDAELARAVSNMPTSAGQIKLM
LENRAMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPNEK
DCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSTGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLN
KGCSYITNQDADTVTIDNTVYCLSKVEGEQHVIKGRPVSSSFDPVKFPEDQFNVALDQVFESIENSQALVDQSNRILASG
YIPEAPRDGQAYVRKDGEWVLLSTFLGSHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSWKVVIIFSLLITPQHGLKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRD
LRTVSADGHGHPGGGGGGFVLGAIALGVATAAAVTCGVAIAKCIRLESEVTAIKNALKKTNEAVSTLGCGPRVLATAVRE
LKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISLDLMTDAELARAVSNMPTSAGQIKLM
LENRAMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPNEK
DCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSTGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLN
KGCSYITNQDADTVTIDNTVYCLSKVEGEQHVIKGRPVSSSFDPVKFPEDQFNVALDQVFESIENSQALVDQSNRILASG
YIPEAPRDGQAYVRKDGEWVLLSTFLGSHHHHHH
;
_entity_poly.pdbx_strand_id                 F 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   TRP n 
1 4   LYS n 
1 5   VAL n 
1 6   VAL n 
1 7   ILE n 
1 8   ILE n 
1 9   PHE n 
1 10  SER n 
1 11  LEU n 
1 12  LEU n 
1 13  ILE n 
1 14  THR n 
1 15  PRO n 
1 16  GLN n 
1 17  HIS n 
1 18  GLY n 
1 19  LEU n 
1 20  LYS n 
1 21  GLU n 
1 22  SER n 
1 23  TYR n 
1 24  LEU n 
1 25  GLU n 
1 26  GLU n 
1 27  SER n 
1 28  CYS n 
1 29  SER n 
1 30  THR n 
1 31  ILE n 
1 32  THR n 
1 33  GLU n 
1 34  GLY n 
1 35  TYR n 
1 36  LEU n 
1 37  SER n 
1 38  VAL n 
1 39  LEU n 
1 40  ARG n 
1 41  THR n 
1 42  GLY n 
1 43  TRP n 
1 44  TYR n 
1 45  THR n 
1 46  ASN n 
1 47  VAL n 
1 48  PHE n 
1 49  THR n 
1 50  LEU n 
1 51  GLU n 
1 52  VAL n 
1 53  GLY n 
1 54  ASP n 
1 55  VAL n 
1 56  GLU n 
1 57  ASN n 
1 58  LEU n 
1 59  THR n 
1 60  CYS n 
1 61  ALA n 
1 62  ASP n 
1 63  GLY n 
1 64  PRO n 
1 65  SER n 
1 66  LEU n 
1 67  ILE n 
1 68  LYS n 
1 69  THR n 
1 70  GLU n 
1 71  LEU n 
1 72  ASP n 
1 73  LEU n 
1 74  THR n 
1 75  LYS n 
1 76  SER n 
1 77  ALA n 
1 78  LEU n 
1 79  ARG n 
1 80  ASP n 
1 81  LEU n 
1 82  ARG n 
1 83  THR n 
1 84  VAL n 
1 85  SER n 
1 86  ALA n 
1 87  ASP n 
1 88  GLY n 
1 89  HIS n 
1 90  GLY n 
1 91  HIS n 
1 92  PRO n 
1 93  GLY n 
1 94  GLY n 
1 95  GLY n 
1 96  GLY n 
1 97  GLY n 
1 98  GLY n 
1 99  PHE n 
1 100 VAL n 
1 101 LEU n 
1 102 GLY n 
1 103 ALA n 
1 104 ILE n 
1 105 ALA n 
1 106 LEU n 
1 107 GLY n 
1 108 VAL n 
1 109 ALA n 
1 110 THR n 
1 111 ALA n 
1 112 ALA n 
1 113 ALA n 
1 114 VAL n 
1 115 THR n 
1 116 CYS n 
1 117 GLY n 
1 118 VAL n 
1 119 ALA n 
1 120 ILE n 
1 121 ALA n 
1 122 LYS n 
1 123 CYS n 
1 124 ILE n 
1 125 ARG n 
1 126 LEU n 
1 127 GLU n 
1 128 SER n 
1 129 GLU n 
1 130 VAL n 
1 131 THR n 
1 132 ALA n 
1 133 ILE n 
1 134 LYS n 
1 135 ASN n 
1 136 ALA n 
1 137 LEU n 
1 138 LYS n 
1 139 LYS n 
1 140 THR n 
1 141 ASN n 
1 142 GLU n 
1 143 ALA n 
1 144 VAL n 
1 145 SER n 
1 146 THR n 
1 147 LEU n 
1 148 GLY n 
1 149 CYS n 
1 150 GLY n 
1 151 PRO n 
1 152 ARG n 
1 153 VAL n 
1 154 LEU n 
1 155 ALA n 
1 156 THR n 
1 157 ALA n 
1 158 VAL n 
1 159 ARG n 
1 160 GLU n 
1 161 LEU n 
1 162 LYS n 
1 163 ASP n 
1 164 PHE n 
1 165 VAL n 
1 166 SER n 
1 167 LYS n 
1 168 ASN n 
1 169 LEU n 
1 170 THR n 
1 171 ARG n 
1 172 ALA n 
1 173 ILE n 
1 174 ASN n 
1 175 LYS n 
1 176 ASN n 
1 177 LYS n 
1 178 CYS n 
1 179 ASP n 
1 180 ILE n 
1 181 PRO n 
1 182 ASP n 
1 183 LEU n 
1 184 LYS n 
1 185 MET n 
1 186 ALA n 
1 187 VAL n 
1 188 SER n 
1 189 PHE n 
1 190 SER n 
1 191 GLN n 
1 192 PHE n 
1 193 ASN n 
1 194 ARG n 
1 195 ARG n 
1 196 PHE n 
1 197 LEU n 
1 198 ASN n 
1 199 VAL n 
1 200 VAL n 
1 201 ARG n 
1 202 GLN n 
1 203 PHE n 
1 204 SER n 
1 205 ASP n 
1 206 ASN n 
1 207 ALA n 
1 208 GLY n 
1 209 ILE n 
1 210 THR n 
1 211 PRO n 
1 212 ALA n 
1 213 ILE n 
1 214 SER n 
1 215 LEU n 
1 216 ASP n 
1 217 LEU n 
1 218 MET n 
1 219 THR n 
1 220 ASP n 
1 221 ALA n 
1 222 GLU n 
1 223 LEU n 
1 224 ALA n 
1 225 ARG n 
1 226 ALA n 
1 227 VAL n 
1 228 SER n 
1 229 ASN n 
1 230 MET n 
1 231 PRO n 
1 232 THR n 
1 233 SER n 
1 234 ALA n 
1 235 GLY n 
1 236 GLN n 
1 237 ILE n 
1 238 LYS n 
1 239 LEU n 
1 240 MET n 
1 241 LEU n 
1 242 GLU n 
1 243 ASN n 
1 244 ARG n 
1 245 ALA n 
1 246 MET n 
1 247 VAL n 
1 248 ARG n 
1 249 ARG n 
1 250 LYS n 
1 251 GLY n 
1 252 PHE n 
1 253 GLY n 
1 254 ILE n 
1 255 LEU n 
1 256 ILE n 
1 257 GLY n 
1 258 VAL n 
1 259 TYR n 
1 260 GLY n 
1 261 SER n 
1 262 SER n 
1 263 VAL n 
1 264 ILE n 
1 265 TYR n 
1 266 MET n 
1 267 VAL n 
1 268 GLN n 
1 269 LEU n 
1 270 PRO n 
1 271 ILE n 
1 272 PHE n 
1 273 GLY n 
1 274 VAL n 
1 275 ILE n 
1 276 ASP n 
1 277 THR n 
1 278 PRO n 
1 279 CYS n 
1 280 TRP n 
1 281 ILE n 
1 282 VAL n 
1 283 LYS n 
1 284 ALA n 
1 285 ALA n 
1 286 PRO n 
1 287 SER n 
1 288 CYS n 
1 289 SER n 
1 290 GLU n 
1 291 LYS n 
1 292 LYS n 
1 293 GLY n 
1 294 ASN n 
1 295 TYR n 
1 296 ALA n 
1 297 CYS n 
1 298 LEU n 
1 299 LEU n 
1 300 ARG n 
1 301 GLU n 
1 302 ASP n 
1 303 GLN n 
1 304 GLY n 
1 305 TRP n 
1 306 TYR n 
1 307 CYS n 
1 308 GLN n 
1 309 ASN n 
1 310 ALA n 
1 311 GLY n 
1 312 SER n 
1 313 THR n 
1 314 VAL n 
1 315 TYR n 
1 316 TYR n 
1 317 PRO n 
1 318 ASN n 
1 319 GLU n 
1 320 LYS n 
1 321 ASP n 
1 322 CYS n 
1 323 GLU n 
1 324 THR n 
1 325 ARG n 
1 326 GLY n 
1 327 ASP n 
1 328 HIS n 
1 329 VAL n 
1 330 PHE n 
1 331 CYS n 
1 332 ASP n 
1 333 THR n 
1 334 ALA n 
1 335 ALA n 
1 336 GLY n 
1 337 ILE n 
1 338 ASN n 
1 339 VAL n 
1 340 ALA n 
1 341 GLU n 
1 342 GLN n 
1 343 SER n 
1 344 LYS n 
1 345 GLU n 
1 346 CYS n 
1 347 ASN n 
1 348 ILE n 
1 349 ASN n 
1 350 ILE n 
1 351 SER n 
1 352 THR n 
1 353 THR n 
1 354 ASN n 
1 355 TYR n 
1 356 PRO n 
1 357 CYS n 
1 358 LYS n 
1 359 VAL n 
1 360 SER n 
1 361 THR n 
1 362 GLY n 
1 363 ARG n 
1 364 HIS n 
1 365 PRO n 
1 366 ILE n 
1 367 SER n 
1 368 MET n 
1 369 VAL n 
1 370 ALA n 
1 371 LEU n 
1 372 SER n 
1 373 PRO n 
1 374 LEU n 
1 375 GLY n 
1 376 ALA n 
1 377 LEU n 
1 378 VAL n 
1 379 ALA n 
1 380 CYS n 
1 381 TYR n 
1 382 LYS n 
1 383 GLY n 
1 384 VAL n 
1 385 SER n 
1 386 CYS n 
1 387 SER n 
1 388 ILE n 
1 389 GLY n 
1 390 SER n 
1 391 ASN n 
1 392 ARG n 
1 393 VAL n 
1 394 GLY n 
1 395 ILE n 
1 396 ILE n 
1 397 LYS n 
1 398 GLN n 
1 399 LEU n 
1 400 ASN n 
1 401 LYS n 
1 402 GLY n 
1 403 CYS n 
1 404 SER n 
1 405 TYR n 
1 406 ILE n 
1 407 THR n 
1 408 ASN n 
1 409 GLN n 
1 410 ASP n 
1 411 ALA n 
1 412 ASP n 
1 413 THR n 
1 414 VAL n 
1 415 THR n 
1 416 ILE n 
1 417 ASP n 
1 418 ASN n 
1 419 THR n 
1 420 VAL n 
1 421 TYR n 
1 422 CYS n 
1 423 LEU n 
1 424 SER n 
1 425 LYS n 
1 426 VAL n 
1 427 GLU n 
1 428 GLY n 
1 429 GLU n 
1 430 GLN n 
1 431 HIS n 
1 432 VAL n 
1 433 ILE n 
1 434 LYS n 
1 435 GLY n 
1 436 ARG n 
1 437 PRO n 
1 438 VAL n 
1 439 SER n 
1 440 SER n 
1 441 SER n 
1 442 PHE n 
1 443 ASP n 
1 444 PRO n 
1 445 VAL n 
1 446 LYS n 
1 447 PHE n 
1 448 PRO n 
1 449 GLU n 
1 450 ASP n 
1 451 GLN n 
1 452 PHE n 
1 453 ASN n 
1 454 VAL n 
1 455 ALA n 
1 456 LEU n 
1 457 ASP n 
1 458 GLN n 
1 459 VAL n 
1 460 PHE n 
1 461 GLU n 
1 462 SER n 
1 463 ILE n 
1 464 GLU n 
1 465 ASN n 
1 466 SER n 
1 467 GLN n 
1 468 ALA n 
1 469 LEU n 
1 470 VAL n 
1 471 ASP n 
1 472 GLN n 
1 473 SER n 
1 474 ASN n 
1 475 ARG n 
1 476 ILE n 
1 477 LEU n 
1 478 ALA n 
1 479 SER n 
1 480 GLY n 
1 481 TYR n 
1 482 ILE n 
1 483 PRO n 
1 484 GLU n 
1 485 ALA n 
1 486 PRO n 
1 487 ARG n 
1 488 ASP n 
1 489 GLY n 
1 490 GLN n 
1 491 ALA n 
1 492 TYR n 
1 493 VAL n 
1 494 ARG n 
1 495 LYS n 
1 496 ASP n 
1 497 GLY n 
1 498 GLU n 
1 499 TRP n 
1 500 VAL n 
1 501 LEU n 
1 502 LEU n 
1 503 SER n 
1 504 THR n 
1 505 PHE n 
1 506 LEU n 
1 507 GLY n 
1 508 SER n 
1 509 HIS n 
1 510 HIS n 
1 511 HIS n 
1 512 HIS n 
1 513 HIS n 
1 514 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   514 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'human metapneumovirus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     162145 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   F . n 
A 1 2   SER 2   2   ?   ?   ?   F . n 
A 1 3   TRP 3   3   ?   ?   ?   F . n 
A 1 4   LYS 4   4   ?   ?   ?   F . n 
A 1 5   VAL 5   5   ?   ?   ?   F . n 
A 1 6   VAL 6   6   ?   ?   ?   F . n 
A 1 7   ILE 7   7   ?   ?   ?   F . n 
A 1 8   ILE 8   8   ?   ?   ?   F . n 
A 1 9   PHE 9   9   ?   ?   ?   F . n 
A 1 10  SER 10  10  ?   ?   ?   F . n 
A 1 11  LEU 11  11  ?   ?   ?   F . n 
A 1 12  LEU 12  12  ?   ?   ?   F . n 
A 1 13  ILE 13  13  ?   ?   ?   F . n 
A 1 14  THR 14  14  ?   ?   ?   F . n 
A 1 15  PRO 15  15  ?   ?   ?   F . n 
A 1 16  GLN 16  16  ?   ?   ?   F . n 
A 1 17  HIS 17  17  ?   ?   ?   F . n 
A 1 18  GLY 18  18  ?   ?   ?   F . n 
A 1 19  LEU 19  19  19  LEU LEU F . n 
A 1 20  LYS 20  20  20  LYS LYS F . n 
A 1 21  GLU 21  21  21  GLU GLU F . n 
A 1 22  SER 22  22  22  SER SER F . n 
A 1 23  TYR 23  23  23  TYR TYR F . n 
A 1 24  LEU 24  24  24  LEU LEU F . n 
A 1 25  GLU 25  25  25  GLU GLU F . n 
A 1 26  GLU 26  26  26  GLU GLU F . n 
A 1 27  SER 27  27  27  SER SER F . n 
A 1 28  CYS 28  28  28  CYS CYS F . n 
A 1 29  SER 29  29  29  SER SER F . n 
A 1 30  THR 30  30  30  THR THR F . n 
A 1 31  ILE 31  31  31  ILE ILE F . n 
A 1 32  THR 32  32  32  THR THR F . n 
A 1 33  GLU 33  33  33  GLU GLU F . n 
A 1 34  GLY 34  34  34  GLY GLY F . n 
A 1 35  TYR 35  35  35  TYR TYR F . n 
A 1 36  LEU 36  36  36  LEU LEU F . n 
A 1 37  SER 37  37  37  SER SER F . n 
A 1 38  VAL 38  38  38  VAL VAL F . n 
A 1 39  LEU 39  39  39  LEU LEU F . n 
A 1 40  ARG 40  40  40  ARG ARG F . n 
A 1 41  THR 41  41  41  THR THR F . n 
A 1 42  GLY 42  42  42  GLY GLY F . n 
A 1 43  TRP 43  43  43  TRP TRP F . n 
A 1 44  TYR 44  44  44  TYR TYR F . n 
A 1 45  THR 45  45  45  THR THR F . n 
A 1 46  ASN 46  46  46  ASN ASN F . n 
A 1 47  VAL 47  47  47  VAL VAL F . n 
A 1 48  PHE 48  48  48  PHE PHE F . n 
A 1 49  THR 49  49  49  THR THR F . n 
A 1 50  LEU 50  50  50  LEU LEU F . n 
A 1 51  GLU 51  51  51  GLU GLU F . n 
A 1 52  VAL 52  52  52  VAL VAL F . n 
A 1 53  GLY 53  53  53  GLY GLY F . n 
A 1 54  ASP 54  54  54  ASP ASP F . n 
A 1 55  VAL 55  55  55  VAL VAL F . n 
A 1 56  GLU 56  56  56  GLU GLU F . n 
A 1 57  ASN 57  57  57  ASN ASN F . n 
A 1 58  LEU 58  58  58  LEU LEU F . n 
A 1 59  THR 59  59  59  THR THR F . n 
A 1 60  CYS 60  60  60  CYS CYS F . n 
A 1 61  ALA 61  61  61  ALA ALA F . n 
A 1 62  ASP 62  62  62  ASP ASP F . n 
A 1 63  GLY 63  63  63  GLY GLY F . n 
A 1 64  PRO 64  64  64  PRO PRO F . n 
A 1 65  SER 65  65  65  SER SER F . n 
A 1 66  LEU 66  66  66  LEU LEU F . n 
A 1 67  ILE 67  67  67  ILE ILE F . n 
A 1 68  LYS 68  68  68  LYS LYS F . n 
A 1 69  THR 69  69  69  THR THR F . n 
A 1 70  GLU 70  70  70  GLU GLU F . n 
A 1 71  LEU 71  71  71  LEU LEU F . n 
A 1 72  ASP 72  72  72  ASP ASP F . n 
A 1 73  LEU 73  73  73  LEU LEU F . n 
A 1 74  THR 74  74  74  THR THR F . n 
A 1 75  LYS 75  75  75  LYS LYS F . n 
A 1 76  SER 76  76  76  SER SER F . n 
A 1 77  ALA 77  77  77  ALA ALA F . n 
A 1 78  LEU 78  78  78  LEU LEU F . n 
A 1 79  ARG 79  79  79  ARG ARG F . n 
A 1 80  ASP 80  80  80  ASP ASP F . n 
A 1 81  LEU 81  81  81  LEU LEU F . n 
A 1 82  ARG 82  82  82  ARG ARG F . n 
A 1 83  THR 83  83  83  THR THR F . n 
A 1 84  VAL 84  84  84  VAL VAL F . n 
A 1 85  SER 85  85  85  SER SER F . n 
A 1 86  ALA 86  86  86  ALA ALA F . n 
A 1 87  ASP 87  87  87  ASP ASP F . n 
A 1 88  GLY 88  88  ?   ?   ?   F . n 
A 1 89  HIS 89  89  ?   ?   ?   F . n 
A 1 90  GLY 90  90  ?   ?   ?   F . n 
A 1 91  HIS 91  91  ?   ?   ?   F . n 
A 1 92  PRO 92  92  ?   ?   ?   F . n 
A 1 93  GLY 93  93  ?   ?   ?   F . n 
A 1 94  GLY 94  94  ?   ?   ?   F . n 
A 1 95  GLY 95  95  ?   ?   ?   F . n 
A 1 96  GLY 96  96  ?   ?   ?   F . n 
A 1 97  GLY 97  97  ?   ?   ?   F . n 
A 1 98  GLY 98  98  ?   ?   ?   F . n 
A 1 99  PHE 99  99  ?   ?   ?   F . n 
A 1 100 VAL 100 100 ?   ?   ?   F . n 
A 1 101 LEU 101 101 ?   ?   ?   F . n 
A 1 102 GLY 102 102 ?   ?   ?   F . n 
A 1 103 ALA 103 103 ?   ?   ?   F . n 
A 1 104 ILE 104 104 ?   ?   ?   F . n 
A 1 105 ALA 105 105 ?   ?   ?   F . n 
A 1 106 LEU 106 106 106 LEU LEU F . n 
A 1 107 GLY 107 107 107 GLY GLY F . n 
A 1 108 VAL 108 108 108 VAL VAL F . n 
A 1 109 ALA 109 109 109 ALA ALA F . n 
A 1 110 THR 110 110 110 THR THR F . n 
A 1 111 ALA 111 111 111 ALA ALA F . n 
A 1 112 ALA 112 112 112 ALA ALA F . n 
A 1 113 ALA 113 113 113 ALA ALA F . n 
A 1 114 VAL 114 114 114 VAL VAL F . n 
A 1 115 THR 115 115 115 THR THR F . n 
A 1 116 CYS 116 116 116 CYS CYS F . n 
A 1 117 GLY 117 117 117 GLY GLY F . n 
A 1 118 VAL 118 118 118 VAL VAL F . n 
A 1 119 ALA 119 119 119 ALA ALA F . n 
A 1 120 ILE 120 120 120 ILE ILE F . n 
A 1 121 ALA 121 121 121 ALA ALA F . n 
A 1 122 LYS 122 122 122 LYS LYS F . n 
A 1 123 CYS 123 123 123 CYS CYS F . n 
A 1 124 ILE 124 124 124 ILE ILE F . n 
A 1 125 ARG 125 125 125 ARG ARG F . n 
A 1 126 LEU 126 126 126 LEU LEU F . n 
A 1 127 GLU 127 127 127 GLU GLU F . n 
A 1 128 SER 128 128 128 SER SER F . n 
A 1 129 GLU 129 129 129 GLU GLU F . n 
A 1 130 VAL 130 130 130 VAL VAL F . n 
A 1 131 THR 131 131 131 THR THR F . n 
A 1 132 ALA 132 132 132 ALA ALA F . n 
A 1 133 ILE 133 133 133 ILE ILE F . n 
A 1 134 LYS 134 134 134 LYS LYS F . n 
A 1 135 ASN 135 135 135 ASN ASN F . n 
A 1 136 ALA 136 136 136 ALA ALA F . n 
A 1 137 LEU 137 137 137 LEU LEU F . n 
A 1 138 LYS 138 138 138 LYS LYS F . n 
A 1 139 LYS 139 139 139 LYS LYS F . n 
A 1 140 THR 140 140 140 THR THR F . n 
A 1 141 ASN 141 141 141 ASN ASN F . n 
A 1 142 GLU 142 142 142 GLU GLU F . n 
A 1 143 ALA 143 143 143 ALA ALA F . n 
A 1 144 VAL 144 144 144 VAL VAL F . n 
A 1 145 SER 145 145 145 SER SER F . n 
A 1 146 THR 146 146 146 THR THR F . n 
A 1 147 LEU 147 147 147 LEU LEU F . n 
A 1 148 GLY 148 148 148 GLY GLY F . n 
A 1 149 CYS 149 149 149 CYS CYS F . n 
A 1 150 GLY 150 150 150 GLY GLY F . n 
A 1 151 PRO 151 151 151 PRO PRO F . n 
A 1 152 ARG 152 152 152 ARG ARG F . n 
A 1 153 VAL 153 153 153 VAL VAL F . n 
A 1 154 LEU 154 154 154 LEU LEU F . n 
A 1 155 ALA 155 155 155 ALA ALA F . n 
A 1 156 THR 156 156 156 THR THR F . n 
A 1 157 ALA 157 157 157 ALA ALA F . n 
A 1 158 VAL 158 158 158 VAL VAL F . n 
A 1 159 ARG 159 159 159 ARG ARG F . n 
A 1 160 GLU 160 160 160 GLU GLU F . n 
A 1 161 LEU 161 161 161 LEU LEU F . n 
A 1 162 LYS 162 162 162 LYS LYS F . n 
A 1 163 ASP 163 163 163 ASP ASP F . n 
A 1 164 PHE 164 164 164 PHE PHE F . n 
A 1 165 VAL 165 165 165 VAL VAL F . n 
A 1 166 SER 166 166 166 SER SER F . n 
A 1 167 LYS 167 167 167 LYS LYS F . n 
A 1 168 ASN 168 168 168 ASN ASN F . n 
A 1 169 LEU 169 169 169 LEU LEU F . n 
A 1 170 THR 170 170 170 THR THR F . n 
A 1 171 ARG 171 171 171 ARG ARG F . n 
A 1 172 ALA 172 172 172 ALA ALA F . n 
A 1 173 ILE 173 173 173 ILE ILE F . n 
A 1 174 ASN 174 174 174 ASN ASN F . n 
A 1 175 LYS 175 175 175 LYS LYS F . n 
A 1 176 ASN 176 176 176 ASN ASN F . n 
A 1 177 LYS 177 177 177 LYS LYS F . n 
A 1 178 CYS 178 178 178 CYS CYS F . n 
A 1 179 ASP 179 179 179 ASP ASP F . n 
A 1 180 ILE 180 180 180 ILE ILE F . n 
A 1 181 PRO 181 181 181 PRO PRO F . n 
A 1 182 ASP 182 182 182 ASP ASP F . n 
A 1 183 LEU 183 183 183 LEU LEU F . n 
A 1 184 LYS 184 184 184 LYS LYS F . n 
A 1 185 MET 185 185 185 MET MET F . n 
A 1 186 ALA 186 186 186 ALA ALA F . n 
A 1 187 VAL 187 187 187 VAL VAL F . n 
A 1 188 SER 188 188 188 SER SER F . n 
A 1 189 PHE 189 189 189 PHE PHE F . n 
A 1 190 SER 190 190 190 SER SER F . n 
A 1 191 GLN 191 191 191 GLN GLN F . n 
A 1 192 PHE 192 192 192 PHE PHE F . n 
A 1 193 ASN 193 193 193 ASN ASN F . n 
A 1 194 ARG 194 194 194 ARG ARG F . n 
A 1 195 ARG 195 195 195 ARG ARG F . n 
A 1 196 PHE 196 196 196 PHE PHE F . n 
A 1 197 LEU 197 197 197 LEU LEU F . n 
A 1 198 ASN 198 198 198 ASN ASN F . n 
A 1 199 VAL 199 199 199 VAL VAL F . n 
A 1 200 VAL 200 200 200 VAL VAL F . n 
A 1 201 ARG 201 201 201 ARG ARG F . n 
A 1 202 GLN 202 202 202 GLN GLN F . n 
A 1 203 PHE 203 203 203 PHE PHE F . n 
A 1 204 SER 204 204 204 SER SER F . n 
A 1 205 ASP 205 205 205 ASP ASP F . n 
A 1 206 ASN 206 206 206 ASN ASN F . n 
A 1 207 ALA 207 207 207 ALA ALA F . n 
A 1 208 GLY 208 208 208 GLY GLY F . n 
A 1 209 ILE 209 209 209 ILE ILE F . n 
A 1 210 THR 210 210 210 THR THR F . n 
A 1 211 PRO 211 211 211 PRO PRO F . n 
A 1 212 ALA 212 212 212 ALA ALA F . n 
A 1 213 ILE 213 213 213 ILE ILE F . n 
A 1 214 SER 214 214 214 SER SER F . n 
A 1 215 LEU 215 215 215 LEU LEU F . n 
A 1 216 ASP 216 216 216 ASP ASP F . n 
A 1 217 LEU 217 217 217 LEU LEU F . n 
A 1 218 MET 218 218 218 MET MET F . n 
A 1 219 THR 219 219 219 THR THR F . n 
A 1 220 ASP 220 220 220 ASP ASP F . n 
A 1 221 ALA 221 221 221 ALA ALA F . n 
A 1 222 GLU 222 222 222 GLU GLU F . n 
A 1 223 LEU 223 223 223 LEU LEU F . n 
A 1 224 ALA 224 224 224 ALA ALA F . n 
A 1 225 ARG 225 225 225 ARG ARG F . n 
A 1 226 ALA 226 226 226 ALA ALA F . n 
A 1 227 VAL 227 227 227 VAL VAL F . n 
A 1 228 SER 228 228 228 SER SER F . n 
A 1 229 ASN 229 229 229 ASN ASN F . n 
A 1 230 MET 230 230 230 MET MET F . n 
A 1 231 PRO 231 231 231 PRO PRO F . n 
A 1 232 THR 232 232 232 THR THR F . n 
A 1 233 SER 233 233 233 SER SER F . n 
A 1 234 ALA 234 234 234 ALA ALA F . n 
A 1 235 GLY 235 235 235 GLY GLY F . n 
A 1 236 GLN 236 236 236 GLN GLN F . n 
A 1 237 ILE 237 237 237 ILE ILE F . n 
A 1 238 LYS 238 238 238 LYS LYS F . n 
A 1 239 LEU 239 239 239 LEU LEU F . n 
A 1 240 MET 240 240 240 MET MET F . n 
A 1 241 LEU 241 241 241 LEU LEU F . n 
A 1 242 GLU 242 242 242 GLU GLU F . n 
A 1 243 ASN 243 243 243 ASN ASN F . n 
A 1 244 ARG 244 244 244 ARG ARG F . n 
A 1 245 ALA 245 245 245 ALA ALA F . n 
A 1 246 MET 246 246 246 MET MET F . n 
A 1 247 VAL 247 247 247 VAL VAL F . n 
A 1 248 ARG 248 248 248 ARG ARG F . n 
A 1 249 ARG 249 249 249 ARG ARG F . n 
A 1 250 LYS 250 250 250 LYS LYS F . n 
A 1 251 GLY 251 251 251 GLY GLY F . n 
A 1 252 PHE 252 252 252 PHE PHE F . n 
A 1 253 GLY 253 253 253 GLY GLY F . n 
A 1 254 ILE 254 254 254 ILE ILE F . n 
A 1 255 LEU 255 255 255 LEU LEU F . n 
A 1 256 ILE 256 256 256 ILE ILE F . n 
A 1 257 GLY 257 257 257 GLY GLY F . n 
A 1 258 VAL 258 258 258 VAL VAL F . n 
A 1 259 TYR 259 259 259 TYR TYR F . n 
A 1 260 GLY 260 260 260 GLY GLY F . n 
A 1 261 SER 261 261 261 SER SER F . n 
A 1 262 SER 262 262 262 SER SER F . n 
A 1 263 VAL 263 263 263 VAL VAL F . n 
A 1 264 ILE 264 264 264 ILE ILE F . n 
A 1 265 TYR 265 265 265 TYR TYR F . n 
A 1 266 MET 266 266 266 MET MET F . n 
A 1 267 VAL 267 267 267 VAL VAL F . n 
A 1 268 GLN 268 268 268 GLN GLN F . n 
A 1 269 LEU 269 269 269 LEU LEU F . n 
A 1 270 PRO 270 270 270 PRO PRO F . n 
A 1 271 ILE 271 271 271 ILE ILE F . n 
A 1 272 PHE 272 272 272 PHE PHE F . n 
A 1 273 GLY 273 273 273 GLY GLY F . n 
A 1 274 VAL 274 274 274 VAL VAL F . n 
A 1 275 ILE 275 275 275 ILE ILE F . n 
A 1 276 ASP 276 276 276 ASP ASP F . n 
A 1 277 THR 277 277 277 THR THR F . n 
A 1 278 PRO 278 278 278 PRO PRO F . n 
A 1 279 CYS 279 279 279 CYS CYS F . n 
A 1 280 TRP 280 280 280 TRP TRP F . n 
A 1 281 ILE 281 281 281 ILE ILE F . n 
A 1 282 VAL 282 282 282 VAL VAL F . n 
A 1 283 LYS 283 283 283 LYS LYS F . n 
A 1 284 ALA 284 284 284 ALA ALA F . n 
A 1 285 ALA 285 285 285 ALA ALA F . n 
A 1 286 PRO 286 286 286 PRO PRO F . n 
A 1 287 SER 287 287 287 SER SER F . n 
A 1 288 CYS 288 288 288 CYS CYS F . n 
A 1 289 SER 289 289 289 SER SER F . n 
A 1 290 GLU 290 290 290 GLU GLU F . n 
A 1 291 LYS 291 291 291 LYS LYS F . n 
A 1 292 LYS 292 292 292 LYS LYS F . n 
A 1 293 GLY 293 293 293 GLY GLY F . n 
A 1 294 ASN 294 294 294 ASN ASN F . n 
A 1 295 TYR 295 295 295 TYR TYR F . n 
A 1 296 ALA 296 296 296 ALA ALA F . n 
A 1 297 CYS 297 297 297 CYS CYS F . n 
A 1 298 LEU 298 298 298 LEU LEU F . n 
A 1 299 LEU 299 299 299 LEU LEU F . n 
A 1 300 ARG 300 300 300 ARG ARG F . n 
A 1 301 GLU 301 301 301 GLU GLU F . n 
A 1 302 ASP 302 302 302 ASP ASP F . n 
A 1 303 GLN 303 303 303 GLN GLN F . n 
A 1 304 GLY 304 304 304 GLY GLY F . n 
A 1 305 TRP 305 305 305 TRP TRP F . n 
A 1 306 TYR 306 306 306 TYR TYR F . n 
A 1 307 CYS 307 307 307 CYS CYS F . n 
A 1 308 GLN 308 308 308 GLN GLN F . n 
A 1 309 ASN 309 309 309 ASN ASN F . n 
A 1 310 ALA 310 310 310 ALA ALA F . n 
A 1 311 GLY 311 311 311 GLY GLY F . n 
A 1 312 SER 312 312 312 SER SER F . n 
A 1 313 THR 313 313 313 THR THR F . n 
A 1 314 VAL 314 314 314 VAL VAL F . n 
A 1 315 TYR 315 315 315 TYR TYR F . n 
A 1 316 TYR 316 316 316 TYR TYR F . n 
A 1 317 PRO 317 317 317 PRO PRO F . n 
A 1 318 ASN 318 318 318 ASN ASN F . n 
A 1 319 GLU 319 319 319 GLU GLU F . n 
A 1 320 LYS 320 320 320 LYS LYS F . n 
A 1 321 ASP 321 321 321 ASP ASP F . n 
A 1 322 CYS 322 322 322 CYS CYS F . n 
A 1 323 GLU 323 323 323 GLU GLU F . n 
A 1 324 THR 324 324 324 THR THR F . n 
A 1 325 ARG 325 325 325 ARG ARG F . n 
A 1 326 GLY 326 326 326 GLY GLY F . n 
A 1 327 ASP 327 327 327 ASP ASP F . n 
A 1 328 HIS 328 328 328 HIS HIS F . n 
A 1 329 VAL 329 329 329 VAL VAL F . n 
A 1 330 PHE 330 330 330 PHE PHE F . n 
A 1 331 CYS 331 331 331 CYS CYS F . n 
A 1 332 ASP 332 332 332 ASP ASP F . n 
A 1 333 THR 333 333 333 THR THR F . n 
A 1 334 ALA 334 334 334 ALA ALA F . n 
A 1 335 ALA 335 335 335 ALA ALA F . n 
A 1 336 GLY 336 336 336 GLY GLY F . n 
A 1 337 ILE 337 337 337 ILE ILE F . n 
A 1 338 ASN 338 338 338 ASN ASN F . n 
A 1 339 VAL 339 339 339 VAL VAL F . n 
A 1 340 ALA 340 340 340 ALA ALA F . n 
A 1 341 GLU 341 341 341 GLU GLU F . n 
A 1 342 GLN 342 342 342 GLN GLN F . n 
A 1 343 SER 343 343 343 SER SER F . n 
A 1 344 LYS 344 344 344 LYS LYS F . n 
A 1 345 GLU 345 345 345 GLU GLU F . n 
A 1 346 CYS 346 346 346 CYS CYS F . n 
A 1 347 ASN 347 347 347 ASN ASN F . n 
A 1 348 ILE 348 348 348 ILE ILE F . n 
A 1 349 ASN 349 349 349 ASN ASN F . n 
A 1 350 ILE 350 350 350 ILE ILE F . n 
A 1 351 SER 351 351 351 SER SER F . n 
A 1 352 THR 352 352 352 THR THR F . n 
A 1 353 THR 353 353 353 THR THR F . n 
A 1 354 ASN 354 354 354 ASN ASN F . n 
A 1 355 TYR 355 355 355 TYR TYR F . n 
A 1 356 PRO 356 356 356 PRO PRO F . n 
A 1 357 CYS 357 357 357 CYS CYS F . n 
A 1 358 LYS 358 358 358 LYS LYS F . n 
A 1 359 VAL 359 359 359 VAL VAL F . n 
A 1 360 SER 360 360 360 SER SER F . n 
A 1 361 THR 361 361 361 THR THR F . n 
A 1 362 GLY 362 362 362 GLY GLY F . n 
A 1 363 ARG 363 363 363 ARG ARG F . n 
A 1 364 HIS 364 364 364 HIS HIS F . n 
A 1 365 PRO 365 365 365 PRO PRO F . n 
A 1 366 ILE 366 366 366 ILE ILE F . n 
A 1 367 SER 367 367 367 SER SER F . n 
A 1 368 MET 368 368 368 MET MET F . n 
A 1 369 VAL 369 369 369 VAL VAL F . n 
A 1 370 ALA 370 370 370 ALA ALA F . n 
A 1 371 LEU 371 371 371 LEU LEU F . n 
A 1 372 SER 372 372 372 SER SER F . n 
A 1 373 PRO 373 373 373 PRO PRO F . n 
A 1 374 LEU 374 374 374 LEU LEU F . n 
A 1 375 GLY 375 375 375 GLY GLY F . n 
A 1 376 ALA 376 376 376 ALA ALA F . n 
A 1 377 LEU 377 377 377 LEU LEU F . n 
A 1 378 VAL 378 378 378 VAL VAL F . n 
A 1 379 ALA 379 379 379 ALA ALA F . n 
A 1 380 CYS 380 380 380 CYS CYS F . n 
A 1 381 TYR 381 381 381 TYR TYR F . n 
A 1 382 LYS 382 382 382 LYS LYS F . n 
A 1 383 GLY 383 383 383 GLY GLY F . n 
A 1 384 VAL 384 384 384 VAL VAL F . n 
A 1 385 SER 385 385 385 SER SER F . n 
A 1 386 CYS 386 386 386 CYS CYS F . n 
A 1 387 SER 387 387 387 SER SER F . n 
A 1 388 ILE 388 388 388 ILE ILE F . n 
A 1 389 GLY 389 389 389 GLY GLY F . n 
A 1 390 SER 390 390 390 SER SER F . n 
A 1 391 ASN 391 391 391 ASN ASN F . n 
A 1 392 ARG 392 392 392 ARG ARG F . n 
A 1 393 VAL 393 393 393 VAL VAL F . n 
A 1 394 GLY 394 394 394 GLY GLY F . n 
A 1 395 ILE 395 395 395 ILE ILE F . n 
A 1 396 ILE 396 396 396 ILE ILE F . n 
A 1 397 LYS 397 397 397 LYS LYS F . n 
A 1 398 GLN 398 398 398 GLN GLN F . n 
A 1 399 LEU 399 399 399 LEU LEU F . n 
A 1 400 ASN 400 400 400 ASN ASN F . n 
A 1 401 LYS 401 401 401 LYS LYS F . n 
A 1 402 GLY 402 402 402 GLY GLY F . n 
A 1 403 CYS 403 403 403 CYS CYS F . n 
A 1 404 SER 404 404 404 SER SER F . n 
A 1 405 TYR 405 405 405 TYR TYR F . n 
A 1 406 ILE 406 406 406 ILE ILE F . n 
A 1 407 THR 407 407 407 THR THR F . n 
A 1 408 ASN 408 408 408 ASN ASN F . n 
A 1 409 GLN 409 409 409 GLN GLN F . n 
A 1 410 ASP 410 410 410 ASP ASP F . n 
A 1 411 ALA 411 411 411 ALA ALA F . n 
A 1 412 ASP 412 412 412 ASP ASP F . n 
A 1 413 THR 413 413 413 THR THR F . n 
A 1 414 VAL 414 414 414 VAL VAL F . n 
A 1 415 THR 415 415 415 THR THR F . n 
A 1 416 ILE 416 416 416 ILE ILE F . n 
A 1 417 ASP 417 417 417 ASP ASP F . n 
A 1 418 ASN 418 418 418 ASN ASN F . n 
A 1 419 THR 419 419 419 THR THR F . n 
A 1 420 VAL 420 420 420 VAL VAL F . n 
A 1 421 TYR 421 421 421 TYR TYR F . n 
A 1 422 CYS 422 422 422 CYS CYS F . n 
A 1 423 LEU 423 423 423 LEU LEU F . n 
A 1 424 SER 424 424 424 SER SER F . n 
A 1 425 LYS 425 425 425 LYS LYS F . n 
A 1 426 VAL 426 426 426 VAL VAL F . n 
A 1 427 GLU 427 427 427 GLU GLU F . n 
A 1 428 GLY 428 428 428 GLY GLY F . n 
A 1 429 GLU 429 429 429 GLU GLU F . n 
A 1 430 GLN 430 430 430 GLN GLN F . n 
A 1 431 HIS 431 431 431 HIS HIS F . n 
A 1 432 VAL 432 432 432 VAL VAL F . n 
A 1 433 ILE 433 433 433 ILE ILE F . n 
A 1 434 LYS 434 434 434 LYS LYS F . n 
A 1 435 GLY 435 435 435 GLY GLY F . n 
A 1 436 ARG 436 436 436 ARG ARG F . n 
A 1 437 PRO 437 437 437 PRO PRO F . n 
A 1 438 VAL 438 438 ?   ?   ?   F . n 
A 1 439 SER 439 439 ?   ?   ?   F . n 
A 1 440 SER 440 440 ?   ?   ?   F . n 
A 1 441 SER 441 441 ?   ?   ?   F . n 
A 1 442 PHE 442 442 ?   ?   ?   F . n 
A 1 443 ASP 443 443 ?   ?   ?   F . n 
A 1 444 PRO 444 444 ?   ?   ?   F . n 
A 1 445 VAL 445 445 ?   ?   ?   F . n 
A 1 446 LYS 446 446 ?   ?   ?   F . n 
A 1 447 PHE 447 447 ?   ?   ?   F . n 
A 1 448 PRO 448 448 ?   ?   ?   F . n 
A 1 449 GLU 449 449 ?   ?   ?   F . n 
A 1 450 ASP 450 450 ?   ?   ?   F . n 
A 1 451 GLN 451 451 ?   ?   ?   F . n 
A 1 452 PHE 452 452 ?   ?   ?   F . n 
A 1 453 ASN 453 453 ?   ?   ?   F . n 
A 1 454 VAL 454 454 454 VAL VAL F . n 
A 1 455 ALA 455 455 455 ALA ALA F . n 
A 1 456 LEU 456 456 456 LEU LEU F . n 
A 1 457 ASP 457 457 457 ASP ASP F . n 
A 1 458 GLN 458 458 458 GLN GLN F . n 
A 1 459 VAL 459 459 459 VAL VAL F . n 
A 1 460 PHE 460 460 460 PHE PHE F . n 
A 1 461 GLU 461 461 461 GLU GLU F . n 
A 1 462 SER 462 462 462 SER SER F . n 
A 1 463 ILE 463 463 463 ILE ILE F . n 
A 1 464 GLU 464 464 464 GLU GLU F . n 
A 1 465 ASN 465 465 465 ASN ASN F . n 
A 1 466 SER 466 466 466 SER SER F . n 
A 1 467 GLN 467 467 467 GLN GLN F . n 
A 1 468 ALA 468 468 468 ALA ALA F . n 
A 1 469 LEU 469 469 ?   ?   ?   F . n 
A 1 470 VAL 470 470 ?   ?   ?   F . n 
A 1 471 ASP 471 471 ?   ?   ?   F . n 
A 1 472 GLN 472 472 ?   ?   ?   F . n 
A 1 473 SER 473 473 ?   ?   ?   F . n 
A 1 474 ASN 474 474 ?   ?   ?   F . n 
A 1 475 ARG 475 475 ?   ?   ?   F . n 
A 1 476 ILE 476 476 ?   ?   ?   F . n 
A 1 477 LEU 477 477 ?   ?   ?   F . n 
A 1 478 ALA 478 478 ?   ?   ?   F . n 
A 1 479 SER 479 479 ?   ?   ?   F . n 
A 1 480 GLY 480 480 ?   ?   ?   F . n 
A 1 481 TYR 481 481 ?   ?   ?   F . n 
A 1 482 ILE 482 482 ?   ?   ?   F . n 
A 1 483 PRO 483 483 ?   ?   ?   F . n 
A 1 484 GLU 484 484 ?   ?   ?   F . n 
A 1 485 ALA 485 485 ?   ?   ?   F . n 
A 1 486 PRO 486 486 ?   ?   ?   F . n 
A 1 487 ARG 487 487 ?   ?   ?   F . n 
A 1 488 ASP 488 488 ?   ?   ?   F . n 
A 1 489 GLY 489 489 ?   ?   ?   F . n 
A 1 490 GLN 490 490 ?   ?   ?   F . n 
A 1 491 ALA 491 491 ?   ?   ?   F . n 
A 1 492 TYR 492 492 ?   ?   ?   F . n 
A 1 493 VAL 493 493 ?   ?   ?   F . n 
A 1 494 ARG 494 494 ?   ?   ?   F . n 
A 1 495 LYS 495 495 ?   ?   ?   F . n 
A 1 496 ASP 496 496 ?   ?   ?   F . n 
A 1 497 GLY 497 497 ?   ?   ?   F . n 
A 1 498 GLU 498 498 ?   ?   ?   F . n 
A 1 499 TRP 499 499 ?   ?   ?   F . n 
A 1 500 VAL 500 500 ?   ?   ?   F . n 
A 1 501 LEU 501 501 ?   ?   ?   F . n 
A 1 502 LEU 502 502 ?   ?   ?   F . n 
A 1 503 SER 503 503 ?   ?   ?   F . n 
A 1 504 THR 504 504 ?   ?   ?   F . n 
A 1 505 PHE 505 505 ?   ?   ?   F . n 
A 1 506 LEU 506 506 ?   ?   ?   F . n 
A 1 507 GLY 507 507 ?   ?   ?   F . n 
A 1 508 SER 508 508 ?   ?   ?   F . n 
A 1 509 HIS 509 509 ?   ?   ?   F . n 
A 1 510 HIS 510 510 ?   ?   ?   F . n 
A 1 511 HIS 511 511 ?   ?   ?   F . n 
A 1 512 HIS 512 512 ?   ?   ?   F . n 
A 1 513 HIS 513 513 ?   ?   ?   F . n 
A 1 514 HIS 514 514 ?   ?   ?   F . n 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W3Q 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     185.745 
_cell.length_a_esd                 ? 
_cell.length_b                     185.745 
_cell.length_b_esd                 ? 
_cell.length_c                     185.745 
_cell.length_c_esd                 ? 
_cell.volume                       6408426.327 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W3Q 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                199 
_symmetry.space_group_name_Hall            'I 2b 2c 3' 
_symmetry.space_group_name_H-M             'I 21 3' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8W3Q 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             4.79 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          74.32 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'0.4M potassium dihydrogen phosphate, 1.2M sodium dihydrogen phosphate, 0.1M phosphate-citrate pH4.37' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-09-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          308.05 
_reflns.entry_id                                       8W3Q 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              5.99 
_reflns.d_resolution_low                               49.64 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     2793 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.57 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                38.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          22.42 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    5.99 
_reflns_shell.d_res_low                                     6.215 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             278 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.728 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               252.07 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8W3Q 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            5.99 
_refine.ls_d_res_low                             49.64 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     2793 
_refine.ls_number_reflns_R_free                  131 
_refine.ls_number_reflns_R_work                  2662 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.89 
_refine.ls_percent_reflns_R_free                 4.69 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2300 
_refine.ls_R_factor_R_free                       0.3546 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2237 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.4104 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.5699 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       5.99 
_refine_hist.d_res_low                        49.64 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               3149 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3149 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0175  ? 3191 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 2.3799  ? 4322 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.1048  ? 517  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0260  ? 553  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.6622 ? 1174 ? f_dihedral_angle_d ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       5.99 
_refine_ls_shell.d_res_low                        49.64 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             131 
_refine_ls_shell.number_reflns_R_work             2662 
_refine_ls_shell.percent_reflns_obs               99.89 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.2237 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.3546 
# 
_struct.entry_id                     8W3Q 
_struct.title                        'Crystal structure of prefusion-stabilized hMPV F protein UFCM1-P2-iSS' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W3Q 
_struct_keywords.text            'Respiratory syncytial virus, glycoprotein, prefusion vaccine, stabilized, viral protein' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8W3Q 
_struct_ref.pdbx_db_accession          8W3Q 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8W3Q 
_struct_ref_seq.pdbx_strand_id                F 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 514 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8W3Q 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  514 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       514 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 9010  ? 
1 MORE         -33   ? 
1 'SSA (A^2)'  56000 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'       1_555 x,y,z 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 
2 'point symmetry operation' ?     ?     0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 
3 'point symmetry operation' ?     ?     0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 65  ? ARG A 82  ? SER F 65  ARG F 82  1 ? 18 
HELX_P HELX_P2  AA2 VAL A 108 ? LEU A 126 ? VAL F 108 LEU F 126 1 ? 19 
HELX_P HELX_P3  AA3 SER A 128 ? LYS A 139 ? SER F 128 LYS F 139 1 ? 12 
HELX_P HELX_P4  AA4 ARG A 159 ? LYS A 167 ? ARG F 159 LYS F 167 1 ? 9  
HELX_P HELX_P5  AA5 LYS A 167 ? ILE A 173 ? LYS F 167 ILE F 173 1 ? 7  
HELX_P HELX_P6  AA6 ASN A 174 ? LYS A 177 ? ASN F 174 LYS F 177 5 ? 4  
HELX_P HELX_P7  AA7 ASP A 182 ? ASN A 206 ? ASP F 182 ASN F 206 1 ? 25 
HELX_P HELX_P8  AA8 THR A 219 ? ASN A 229 ? THR F 219 ASN F 229 1 ? 11 
HELX_P HELX_P9  AA9 SER A 233 ? ASN A 243 ? SER F 233 ASN F 243 1 ? 11 
HELX_P HELX_P10 AB1 ASN A 243 ? GLY A 251 ? ASN F 243 GLY F 251 1 ? 9  
HELX_P HELX_P11 AB2 ASN A 318 ? LYS A 320 ? ASN F 318 LYS F 320 5 ? 3  
HELX_P HELX_P12 AB3 ALA A 334 ? GLY A 336 ? ALA F 334 GLY F 336 5 ? 3  
HELX_P HELX_P13 AB4 ALA A 340 ? SER A 343 ? ALA F 340 SER F 343 5 ? 4  
HELX_P HELX_P14 AB5 LYS A 344 ? ASN A 349 ? LYS F 344 ASN F 349 1 ? 6  
HELX_P HELX_P15 AB6 ALA A 455 ? ALA A 468 ? ALA F 455 ALA F 468 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 28  SG ? ? ? 1_555 A CYS 403 SG ? ? F CYS 28  F CYS 403 1_555 ? ? ? ? ? ? ? 2.035 ? ? 
disulf2 disulf ? ? A CYS 60  SG ? ? ? 1_555 A CYS 178 SG ? ? F CYS 60  F CYS 178 1_555 ? ? ? ? ? ? ? 2.035 ? ? 
disulf3 disulf ? ? A CYS 123 SG ? ? ? 1_555 A CYS 149 SG ? ? F CYS 123 F CYS 149 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf4 disulf ? ? A CYS 279 SG ? ? ? 1_555 A CYS 307 SG ? ? F CYS 279 F CYS 307 1_555 ? ? ? ? ? ? ? 2.045 ? ? 
disulf5 disulf ? ? A CYS 288 SG ? ? ? 1_555 A CYS 297 SG ? ? F CYS 288 F CYS 297 1_555 ? ? ? ? ? ? ? 2.045 ? ? 
disulf6 disulf ? ? A CYS 322 SG ? ? ? 1_555 A CYS 331 SG ? ? F CYS 322 F CYS 331 1_555 ? ? ? ? ? ? ? 2.032 ? ? 
disulf7 disulf ? ? A CYS 346 SG ? ? ? 1_555 A CYS 357 SG ? ? F CYS 346 F CYS 357 1_555 ? ? ? ? ? ? ? 2.019 ? ? 
disulf8 disulf ? ? A CYS 380 SG ? ? ? 1_555 A CYS 386 SG ? ? F CYS 380 F CYS 386 1_555 ? ? ? ? ? ? ? 2.048 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 28  ? CYS A 403 ? CYS F 28  ? 1_555 CYS F 403 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 60  ? CYS A 178 ? CYS F 60  ? 1_555 CYS F 178 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 123 ? CYS A 149 ? CYS F 123 ? 1_555 CYS F 149 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 279 ? CYS A 307 ? CYS F 279 ? 1_555 CYS F 307 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS A 288 ? CYS A 297 ? CYS F 288 ? 1_555 CYS F 297 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS A 322 ? CYS A 331 ? CYS F 322 ? 1_555 CYS F 331 ? 1_555 SG SG . . . None 'Disulfide bridge' 
7 CYS A 346 ? CYS A 357 ? CYS F 346 ? 1_555 CYS F 357 ? 1_555 SG SG . . . None 'Disulfide bridge' 
8 CYS A 380 ? CYS A 386 ? CYS F 380 ? 1_555 CYS F 386 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 5 ? 
AA4 ? 3 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? parallel      
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 CYS A 322 ? ARG A 325 ? CYS F 322 ARG F 325 
AA1 2 HIS A 328 ? ASP A 332 ? HIS F 328 ASP F 332 
AA1 3 SER A 29  ? ARG A 40  ? SER F 29  ARG F 40  
AA1 4 VAL A 274 ? ALA A 284 ? VAL F 274 ALA F 284 
AA1 5 GLY A 304 ? ASN A 309 ? GLY F 304 ASN F 309 
AA1 6 SER A 312 ? TYR A 316 ? SER F 312 TYR F 316 
AA1 7 ILE A 337 ? VAL A 339 ? ILE F 337 VAL F 339 
AA2 1 CYS A 322 ? ARG A 325 ? CYS F 322 ARG F 325 
AA2 2 HIS A 328 ? ASP A 332 ? HIS F 328 ASP F 332 
AA2 3 SER A 29  ? ARG A 40  ? SER F 29  ARG F 40  
AA2 4 LYS A 20  ? LEU A 24  ? LYS F 20  LEU F 24  
AA2 5 GLU A 429 ? ILE A 433 ? GLU F 429 ILE F 433 
AA3 1 GLU A 142 ? SER A 145 ? GLU F 142 SER F 145 
AA3 2 VAL A 153 ? VAL A 158 ? VAL F 153 VAL F 158 
AA3 3 GLY A 42  ? GLU A 51  ? GLY F 42  GLU F 51  
AA3 4 SER A 262 ? ILE A 271 ? SER F 262 ILE F 271 
AA3 5 PHE A 252 ? TYR A 259 ? PHE F 252 TYR F 259 
AA4 1 SER A 287 ? LYS A 291 ? SER F 287 LYS F 291 
AA4 2 ASN A 294 ? ARG A 300 ? ASN F 294 ARG F 300 
AA4 3 VAL A 359 ? GLY A 362 ? VAL F 359 GLY F 362 
AA5 1 MET A 368 ? SER A 372 ? MET F 368 SER F 372 
AA5 2 GLY A 375 ? CYS A 380 ? GLY F 375 CYS F 380 
AA5 3 GLY A 402 ? THR A 407 ? GLY F 402 THR F 407 
AA6 1 GLY A 394 ? GLN A 398 ? GLY F 394 GLN F 398 
AA6 2 CYS A 386 ? SER A 390 ? CYS F 386 SER F 390 
AA6 3 THR A 413 ? ILE A 416 ? THR F 413 ILE F 416 
AA6 4 THR A 419 ? CYS A 422 ? THR F 419 CYS F 422 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLU A 323 ? N GLU F 323 O PHE A 330 ? O PHE F 330 
AA1 2 3 O CYS A 331 ? O CYS F 331 N ARG A 40  ? N ARG F 40  
AA1 3 4 N LEU A 39  ? N LEU F 39  O VAL A 274 ? O VAL F 274 
AA1 4 5 N PRO A 278 ? N PRO F 278 O GLN A 308 ? O GLN F 308 
AA1 5 6 N CYS A 307 ? N CYS F 307 O VAL A 314 ? O VAL F 314 
AA1 6 7 N THR A 313 ? N THR F 313 O VAL A 339 ? O VAL F 339 
AA2 1 2 N GLU A 323 ? N GLU F 323 O PHE A 330 ? O PHE F 330 
AA2 2 3 O CYS A 331 ? O CYS F 331 N ARG A 40  ? N ARG F 40  
AA2 3 4 O ILE A 31  ? O ILE F 31  N SER A 22  ? N SER F 22  
AA2 4 5 N TYR A 23  ? N TYR F 23  O HIS A 431 ? O HIS F 431 
AA3 1 2 N ALA A 143 ? N ALA F 143 O ALA A 155 ? O ALA F 155 
AA3 2 3 O VAL A 158 ? O VAL F 158 N THR A 49  ? N THR F 49  
AA3 3 4 N TYR A 44  ? N TYR F 44  O LEU A 269 ? O LEU F 269 
AA3 4 5 O MET A 266 ? O MET F 266 N ILE A 254 ? N ILE F 254 
AA4 1 2 N LYS A 291 ? N LYS F 291 O ASN A 294 ? O ASN F 294 
AA4 2 3 N CYS A 297 ? N CYS F 297 O GLY A 362 ? O GLY F 362 
AA5 1 2 N MET A 368 ? N MET F 368 O ALA A 379 ? O ALA F 379 
AA5 2 3 N VAL A 378 ? N VAL F 378 O SER A 404 ? O SER F 404 
AA6 1 2 O ILE A 396 ? O ILE F 396 N ILE A 388 ? N ILE F 388 
AA6 2 3 N SER A 387 ? N SER F 387 O THR A 415 ? O THR F 415 
AA6 3 4 N VAL A 414 ? N VAL F 414 O TYR A 421 ? O TYR F 421 
# 
_pdbx_entry_details.entry_id                   8W3Q 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O F LEU 217 ? ? OH  F TYR 265 ? ? 1.85 
2 1 O F VAL 165 ? ? OG1 F THR 170 ? ? 2.03 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 C  F ALA 143 ? ? N  F VAL 144 ? ? 1.516 1.336 0.180  0.023 Y 
2 1 CB F CYS 331 ? ? SG F CYS 331 ? ? 1.705 1.812 -0.107 0.016 N 
3 1 CB F CYS 422 ? ? SG F CYS 422 ? ? 1.698 1.812 -0.114 0.016 N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1  1 CA F CYS 28  ? ? CB F CYS 28  ? ? SG F CYS 28  ? ? 126.09 114.20 11.89  1.10 N 
2  1 CA F GLU 51  ? ? CB F GLU 51  ? ? CG F GLU 51  ? ? 129.87 113.40 16.47  2.20 N 
3  1 CA F CYS 60  ? ? CB F CYS 60  ? ? SG F CYS 60  ? ? 121.05 114.20 6.85   1.10 N 
4  1 CA F LEU 106 ? ? CB F LEU 106 ? ? CG F LEU 106 ? ? 129.62 115.30 14.32  2.30 N 
5  1 CA F CYS 116 ? ? CB F CYS 116 ? ? SG F CYS 116 ? ? 125.07 114.20 10.87  1.10 N 
6  1 O  F ALA 143 ? ? C  F ALA 143 ? ? N  F VAL 144 ? ? 133.99 122.70 11.29  1.60 Y 
7  1 CA F LEU 169 ? ? CB F LEU 169 ? ? CG F LEU 169 ? ? 136.33 115.30 21.03  2.30 N 
8  1 CB F MET 218 ? ? CG F MET 218 ? ? SD F MET 218 ? ? 90.69  112.40 -21.71 3.00 N 
9  1 C  F MET 230 ? ? N  F PRO 231 ? ? CA F PRO 231 ? ? 128.73 119.30 9.43   1.50 Y 
10 1 CA F LEU 241 ? ? CB F LEU 241 ? ? CG F LEU 241 ? ? 97.92  115.30 -17.38 2.30 N 
11 1 CA F CYS 357 ? ? CB F CYS 357 ? ? SG F CYS 357 ? ? 123.05 114.20 8.85   1.10 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP F 62  ? ? -92.83  35.25   
2  1 VAL F 108 ? ? 73.42   -51.82  
3  1 CYS F 123 ? ? -58.76  -2.68   
4  1 GLU F 127 ? ? 37.93   31.43   
5  1 ARG F 152 ? ? 58.52   79.32   
6  1 LYS F 167 ? ? -81.10  -80.14  
7  1 ASN F 243 ? ? -105.94 51.32   
8  1 LYS F 320 ? ? -59.43  -7.01   
9  1 GLU F 341 ? ? -57.88  -1.71   
10 1 LYS F 397 ? ? -174.57 145.87  
11 1 ASP F 417 ? ? 51.89   -116.30 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG F 125 ? ? 0.121 'SIDE CHAIN' 
2 1 ARG F 152 ? ? 0.284 'SIDE CHAIN' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z             
2  z,x,y             
3  y,z,x             
4  -y,-z+1/2,x       
5  z,-x,-y+1/2       
6  -y+1/2,z,-x       
7  -z,-x+1/2,y       
8  -z+1/2,x,-y       
9  y,-z,-x+1/2       
10 x,-y,-z+1/2       
11 -x+1/2,y,-z       
12 -x,-y+1/2,z       
13 x+1/2,y+1/2,z+1/2 
14 z+1/2,x+1/2,y+1/2 
15 y+1/2,z+1/2,x+1/2 
16 -y+1/2,-z+1,x+1/2 
17 z+1/2,-x+1/2,-y+1 
18 -y+1,z+1/2,-x+1/2 
19 -z+1/2,-x+1,y+1/2 
20 -z+1,x+1/2,-y+1/2 
21 y+1/2,-z+1/2,-x+1 
22 x+1/2,-y+1/2,-z+1 
23 -x+1,y+1/2,-z+1/2 
24 -x+1/2,-y+1,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 F MET 1   ? A MET 1   
2  1 Y 1 F SER 2   ? A SER 2   
3  1 Y 1 F TRP 3   ? A TRP 3   
4  1 Y 1 F LYS 4   ? A LYS 4   
5  1 Y 1 F VAL 5   ? A VAL 5   
6  1 Y 1 F VAL 6   ? A VAL 6   
7  1 Y 1 F ILE 7   ? A ILE 7   
8  1 Y 1 F ILE 8   ? A ILE 8   
9  1 Y 1 F PHE 9   ? A PHE 9   
10 1 Y 1 F SER 10  ? A SER 10  
11 1 Y 1 F LEU 11  ? A LEU 11  
12 1 Y 1 F LEU 12  ? A LEU 12  
13 1 Y 1 F ILE 13  ? A ILE 13  
14 1 Y 1 F THR 14  ? A THR 14  
15 1 Y 1 F PRO 15  ? A PRO 15  
16 1 Y 1 F GLN 16  ? A GLN 16  
17 1 Y 1 F HIS 17  ? A HIS 17  
18 1 Y 1 F GLY 18  ? A GLY 18  
19 1 Y 1 F GLY 88  ? A GLY 88  
20 1 Y 1 F HIS 89  ? A HIS 89  
21 1 Y 1 F GLY 90  ? A GLY 90  
22 1 Y 1 F HIS 91  ? A HIS 91  
23 1 Y 1 F PRO 92  ? A PRO 92  
24 1 Y 1 F GLY 93  ? A GLY 93  
25 1 Y 1 F GLY 94  ? A GLY 94  
26 1 Y 1 F GLY 95  ? A GLY 95  
27 1 Y 1 F GLY 96  ? A GLY 96  
28 1 Y 1 F GLY 97  ? A GLY 97  
29 1 Y 1 F GLY 98  ? A GLY 98  
30 1 Y 1 F PHE 99  ? A PHE 99  
31 1 Y 1 F VAL 100 ? A VAL 100 
32 1 Y 1 F LEU 101 ? A LEU 101 
33 1 Y 1 F GLY 102 ? A GLY 102 
34 1 Y 1 F ALA 103 ? A ALA 103 
35 1 Y 1 F ILE 104 ? A ILE 104 
36 1 Y 1 F ALA 105 ? A ALA 105 
37 1 Y 1 F VAL 438 ? A VAL 438 
38 1 Y 1 F SER 439 ? A SER 439 
39 1 Y 1 F SER 440 ? A SER 440 
40 1 Y 1 F SER 441 ? A SER 441 
41 1 Y 1 F PHE 442 ? A PHE 442 
42 1 Y 1 F ASP 443 ? A ASP 443 
43 1 Y 1 F PRO 444 ? A PRO 444 
44 1 Y 1 F VAL 445 ? A VAL 445 
45 1 Y 1 F LYS 446 ? A LYS 446 
46 1 Y 1 F PHE 447 ? A PHE 447 
47 1 Y 1 F PRO 448 ? A PRO 448 
48 1 Y 1 F GLU 449 ? A GLU 449 
49 1 Y 1 F ASP 450 ? A ASP 450 
50 1 Y 1 F GLN 451 ? A GLN 451 
51 1 Y 1 F PHE 452 ? A PHE 452 
52 1 Y 1 F ASN 453 ? A ASN 453 
53 1 Y 1 F LEU 469 ? A LEU 469 
54 1 Y 1 F VAL 470 ? A VAL 470 
55 1 Y 1 F ASP 471 ? A ASP 471 
56 1 Y 1 F GLN 472 ? A GLN 472 
57 1 Y 1 F SER 473 ? A SER 473 
58 1 Y 1 F ASN 474 ? A ASN 474 
59 1 Y 1 F ARG 475 ? A ARG 475 
60 1 Y 1 F ILE 476 ? A ILE 476 
61 1 Y 1 F LEU 477 ? A LEU 477 
62 1 Y 1 F ALA 478 ? A ALA 478 
63 1 Y 1 F SER 479 ? A SER 479 
64 1 Y 1 F GLY 480 ? A GLY 480 
65 1 Y 1 F TYR 481 ? A TYR 481 
66 1 Y 1 F ILE 482 ? A ILE 482 
67 1 Y 1 F PRO 483 ? A PRO 483 
68 1 Y 1 F GLU 484 ? A GLU 484 
69 1 Y 1 F ALA 485 ? A ALA 485 
70 1 Y 1 F PRO 486 ? A PRO 486 
71 1 Y 1 F ARG 487 ? A ARG 487 
72 1 Y 1 F ASP 488 ? A ASP 488 
73 1 Y 1 F GLY 489 ? A GLY 489 
74 1 Y 1 F GLN 490 ? A GLN 490 
75 1 Y 1 F ALA 491 ? A ALA 491 
76 1 Y 1 F TYR 492 ? A TYR 492 
77 1 Y 1 F VAL 493 ? A VAL 493 
78 1 Y 1 F ARG 494 ? A ARG 494 
79 1 Y 1 F LYS 495 ? A LYS 495 
80 1 Y 1 F ASP 496 ? A ASP 496 
81 1 Y 1 F GLY 497 ? A GLY 497 
82 1 Y 1 F GLU 498 ? A GLU 498 
83 1 Y 1 F TRP 499 ? A TRP 499 
84 1 Y 1 F VAL 500 ? A VAL 500 
85 1 Y 1 F LEU 501 ? A LEU 501 
86 1 Y 1 F LEU 502 ? A LEU 502 
87 1 Y 1 F SER 503 ? A SER 503 
88 1 Y 1 F THR 504 ? A THR 504 
89 1 Y 1 F PHE 505 ? A PHE 505 
90 1 Y 1 F LEU 506 ? A LEU 506 
91 1 Y 1 F GLY 507 ? A GLY 507 
92 1 Y 1 F SER 508 ? A SER 508 
93 1 Y 1 F HIS 509 ? A HIS 509 
94 1 Y 1 F HIS 510 ? A HIS 510 
95 1 Y 1 F HIS 511 ? A HIS 511 
96 1 Y 1 F HIS 512 ? A HIS 512 
97 1 Y 1 F HIS 513 ? A HIS 513 
98 1 Y 1 F HIS 514 ? A HIS 514 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5WB0 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 21 3' 
_space_group.name_Hall        'I 2b 2c 3' 
_space_group.IT_number        199 
_space_group.crystal_system   cubic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W3Q 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005384 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005384 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005384 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 5.96793  ? ? ? 14.89577 ? ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 6.96715  ? ? ? 11.43723 ? ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 7.96527  ? ? ? 9.05267  ? ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 15.91112 ? ? ? 10.84690 ? ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . LEU A 1 19  ? -43.32500 -0.72100  -34.72200 1.000 223.51493 ? 19  LEU F N   1 
ATOM 2    C CA  . LEU A 1 19  ? -43.97500 -0.20700  -33.51700 1.000 217.08498 ? 19  LEU F CA  1 
ATOM 3    C C   . LEU A 1 19  ? -45.48600 -0.55200  -33.60300 1.000 219.14679 ? 19  LEU F C   1 
ATOM 4    O O   . LEU A 1 19  ? -46.30100 -0.06700  -32.80500 1.000 228.27880 ? 19  LEU F O   1 
ATOM 5    C CB  . LEU A 1 19  ? -43.72800 1.31600   -33.34300 1.000 212.14583 ? 19  LEU F CB  1 
ATOM 6    C CG  . LEU A 1 19  ? -42.26400 1.77400   -33.12200 1.000 201.04338 ? 19  LEU F CG  1 
ATOM 7    C CD1 . LEU A 1 19  ? -42.17200 3.27400   -32.76100 1.000 190.81970 ? 19  LEU F CD1 1 
ATOM 8    C CD2 . LEU A 1 19  ? -41.41800 0.85800   -32.17100 1.000 196.34996 ? 19  LEU F CD2 1 
ATOM 9    N N   . LYS A 1 20  ? -45.82000 -1.39900  -34.58800 1.000 211.28021 ? 20  LYS F N   1 
ATOM 10   C CA  . LYS A 1 20  ? -47.17700 -1.83500  -34.92100 1.000 207.47921 ? 20  LYS F CA  1 
ATOM 11   C C   . LYS A 1 20  ? -47.09500 -3.35400  -35.06200 1.000 202.55882 ? 20  LYS F C   1 
ATOM 12   O O   . LYS A 1 20  ? -46.28700 -3.89400  -35.83300 1.000 198.53611 ? 20  LYS F O   1 
ATOM 13   C CB  . LYS A 1 20  ? -47.78000 -1.15600  -36.16500 1.000 212.55000 ? 20  LYS F CB  1 
ATOM 14   C CG  . LYS A 1 20  ? -47.55900 0.40400   -36.44500 1.000 212.55725 ? 20  LYS F CG  1 
ATOM 15   C CD  . LYS A 1 20  ? -47.40800 1.36900   -35.25200 1.000 215.47668 ? 20  LYS F CD  1 
ATOM 16   C CE  . LYS A 1 20  ? -47.31500 2.84400   -35.68500 1.000 199.42531 ? 20  LYS F CE  1 
ATOM 17   N NZ  . LYS A 1 20  ? -46.59400 3.73400   -34.69900 1.000 194.60909 ? 20  LYS F NZ  1 
ATOM 18   N N   . GLU A 1 21  ? -47.83400 -4.02200  -34.21000 1.000 209.63947 ? 21  GLU F N   1 
ATOM 19   C CA  . GLU A 1 21  ? -47.84300 -5.46200  -34.06300 1.000 216.71481 ? 21  GLU F CA  1 
ATOM 20   C C   . GLU A 1 21  ? -49.13400 -6.06500  -34.57300 1.000 221.89442 ? 21  GLU F C   1 
ATOM 21   O O   . GLU A 1 21  ? -50.21200 -5.53000  -34.30900 1.000 232.52343 ? 21  GLU F O   1 
ATOM 22   C CB  . GLU A 1 21  ? -47.69800 -5.79400  -32.57200 1.000 235.95478 ? 21  GLU F CB  1 
ATOM 23   C CG  . GLU A 1 21  ? -47.63700 -7.28200  -32.16200 1.000 246.05539 ? 21  GLU F CG  1 
ATOM 24   C CD  . GLU A 1 21  ? -47.05800 -7.51500  -30.73300 1.000 241.99741 ? 21  GLU F CD  1 
ATOM 25   O OE1 . GLU A 1 21  ? -45.89200 -7.15600  -30.45700 1.000 239.54280 ? 21  GLU F OE1 1 
ATOM 26   O OE2 . GLU A 1 21  ? -47.78200 -8.07600  -29.87300 1.000 239.84623 ? 21  GLU F OE2 1 
ATOM 27   N N   . SER A 1 22  ? -49.02300 -7.11900  -35.37500 1.000 218.82877 ? 22  SER F N   1 
ATOM 28   C CA  . SER A 1 22  ? -50.20400 -7.80400  -35.87600 1.000 229.39066 ? 22  SER F CA  1 
ATOM 29   C C   . SER A 1 22  ? -50.33200 -9.22900  -35.32600 1.000 231.43719 ? 22  SER F C   1 
ATOM 30   O O   . SER A 1 22  ? -49.41600 -10.04700 -35.47000 1.000 223.97926 ? 22  SER F O   1 
ATOM 31   C CB  . SER A 1 22  ? -50.19000 -7.83200  -37.38900 1.000 226.62044 ? 22  SER F CB  1 
ATOM 32   O OG  . SER A 1 22  ? -51.25300 -8.65700  -37.80800 1.000 234.17780 ? 22  SER F OG  1 
ATOM 33   N N   . TYR A 1 23  ? -51.47700 -9.50000  -34.69100 1.000 246.46810 ? 23  TYR F N   1 
ATOM 34   C CA  . TYR A 1 23  ? -51.93300 -10.81100 -34.23300 1.000 253.36891 ? 23  TYR F CA  1 
ATOM 35   C C   . TYR A 1 23  ? -52.70500 -11.53000 -35.33500 1.000 255.84920 ? 23  TYR F C   1 
ATOM 36   O O   . TYR A 1 23  ? -53.72000 -11.01000 -35.83100 1.000 256.42814 ? 23  TYR F O   1 
ATOM 37   C CB  . TYR A 1 23  ? -52.80700 -10.69400 -32.97700 1.000 257.99747 ? 23  TYR F CB  1 
ATOM 38   C CG  . TYR A 1 23  ? -53.65900 -11.92500 -32.57400 1.000 257.42755 ? 23  TYR F CG  1 
ATOM 39   C CD1 . TYR A 1 23  ? -53.09600 -13.19900 -32.44400 1.000 253.40931 ? 23  TYR F CD1 1 
ATOM 40   C CD2 . TYR A 1 23  ? -55.01200 -11.79100 -32.24500 1.000 255.58676 ? 23  TYR F CD2 1 
ATOM 41   C CE1 . TYR A 1 23  ? -53.87200 -14.30800 -32.03700 1.000 249.27756 ? 23  TYR F CE1 1 
ATOM 42   C CE2 . TYR A 1 23  ? -55.79200 -12.89400 -31.83800 1.000 252.61476 ? 23  TYR F CE2 1 
ATOM 43   C CZ  . TYR A 1 23  ? -55.21400 -14.14700 -31.73600 1.000 251.68988 ? 23  TYR F CZ  1 
ATOM 44   O OH  . TYR A 1 23  ? -55.96400 -15.23500 -31.33700 1.000 251.78349 ? 23  TYR F OH  1 
ATOM 45   N N   . LEU A 1 24  ? -52.23000 -12.71300 -35.71300 1.000 258.42531 ? 24  LEU F N   1 
ATOM 46   C CA  . LEU A 1 24  ? -52.81900 -13.50400 -36.78100 1.000 263.11418 ? 24  LEU F CA  1 
ATOM 47   C C   . LEU A 1 24  ? -53.76300 -14.48700 -36.10400 1.000 262.91120 ? 24  LEU F C   1 
ATOM 48   O O   . LEU A 1 24  ? -53.32700 -15.49100 -35.50900 1.000 258.01232 ? 24  LEU F O   1 
ATOM 49   C CB  . LEU A 1 24  ? -51.78500 -14.23900 -37.63600 1.000 263.08783 ? 24  LEU F CB  1 
ATOM 50   C CG  . LEU A 1 24  ? -50.50600 -13.66000 -38.24000 1.000 255.77841 ? 24  LEU F CG  1 
ATOM 51   C CD1 . LEU A 1 24  ? -49.64000 -14.76100 -38.82000 1.000 260.90140 ? 24  LEU F CD1 1 
ATOM 52   C CD2 . LEU A 1 24  ? -50.90200 -12.73300 -39.36000 1.000 262.50142 ? 24  LEU F CD2 1 
ATOM 53   N N   . GLU A 1 25  ? -55.05000 -14.10200 -36.10200 1.000 262.98118 ? 25  GLU F N   1 
ATOM 54   C CA  . GLU A 1 25  ? -56.08500 -14.85400 -35.41900 1.000 259.91413 ? 25  GLU F CA  1 
ATOM 55   C C   . GLU A 1 25  ? -56.20200 -16.21100 -36.07200 1.000 259.96903 ? 25  GLU F C   1 
ATOM 56   O O   . GLU A 1 25  ? -56.39700 -17.22800 -35.40000 1.000 249.72082 ? 25  GLU F O   1 
ATOM 57   C CB  . GLU A 1 25  ? -57.40300 -14.05500 -35.58400 1.000 263.97844 ? 25  GLU F CB  1 
ATOM 58   C CG  . GLU A 1 25  ? -58.69500 -14.43600 -34.80200 1.000 272.09218 ? 25  GLU F CG  1 
ATOM 59   C CD  . GLU A 1 25  ? -59.99300 -13.63900 -35.23400 1.000 272.69788 ? 25  GLU F CD  1 
ATOM 60   O OE1 . GLU A 1 25  ? -60.20200 -12.48600 -34.80300 1.000 270.13119 ? 25  GLU F OE1 1 
ATOM 61   O OE2 . GLU A 1 25  ? -60.84700 -14.20000 -35.98100 1.000 271.17728 ? 25  GLU F OE2 1 
ATOM 62   N N   . GLU A 1 26  ? -55.91300 -16.23600 -37.36900 1.000 270.37531 ? 26  GLU F N   1 
ATOM 63   C CA  . GLU A 1 26  ? -56.02500 -17.38300 -38.25400 1.000 281.38997 ? 26  GLU F CA  1 
ATOM 64   C C   . GLU A 1 26  ? -54.90900 -18.39300 -38.02100 1.000 277.76338 ? 26  GLU F C   1 
ATOM 65   O O   . GLU A 1 26  ? -55.02000 -19.54200 -38.45800 1.000 277.34064 ? 26  GLU F O   1 
ATOM 66   C CB  . GLU A 1 26  ? -56.11400 -16.84900 -39.72400 1.000 288.05990 ? 26  GLU F CB  1 
ATOM 67   C CG  . GLU A 1 26  ? -54.87200 -16.09300 -40.37000 1.000 282.20154 ? 26  GLU F CG  1 
ATOM 68   C CD  . GLU A 1 26  ? -54.16800 -16.81300 -41.56300 1.000 277.54728 ? 26  GLU F CD  1 
ATOM 69   O OE1 . GLU A 1 26  ? -54.67600 -17.81000 -42.11200 1.000 271.52997 ? 26  GLU F OE1 1 
ATOM 70   O OE2 . GLU A 1 26  ? -53.05000 -16.37100 -41.94200 1.000 278.38600 ? 26  GLU F OE2 1 
ATOM 71   N N   . SER A 1 27  ? -53.89600 -18.03500 -37.23900 1.000 271.23632 ? 27  SER F N   1 
ATOM 72   C CA  . SER A 1 27  ? -52.78300 -18.95400 -37.05500 1.000 270.63028 ? 27  SER F CA  1 
ATOM 73   C C   . SER A 1 27  ? -52.27900 -18.91200 -35.63800 1.000 263.99386 ? 27  SER F C   1 
ATOM 74   O O   . SER A 1 27  ? -51.21100 -19.47100 -35.38300 1.000 265.06296 ? 27  SER F O   1 
ATOM 75   C CB  . SER A 1 27  ? -51.57300 -18.65700 -37.96400 1.000 271.21517 ? 27  SER F CB  1 
ATOM 76   O OG  . SER A 1 27  ? -51.02400 -17.37100 -37.72200 1.000 258.34092 ? 27  SER F OG  1 
ATOM 77   N N   . CYS A 1 28  ? -52.97100 -18.21900 -34.72900 1.000 259.82492 ? 28  CYS F N   1 
ATOM 78   C CA  . CYS A 1 28  ? -52.52000 -18.16700 -33.34500 1.000 263.39178 ? 28  CYS F CA  1 
ATOM 79   C C   . CYS A 1 28  ? -51.06300 -17.69200 -33.33800 1.000 253.85366 ? 28  CYS F C   1 
ATOM 80   O O   . CYS A 1 28  ? -50.18200 -18.29600 -32.72000 1.000 252.15194 ? 28  CYS F O   1 
ATOM 81   C CB  . CYS A 1 28  ? -52.70500 -19.57800 -32.73200 1.000 285.22918 ? 28  CYS F CB  1 
ATOM 82   S SG  . CYS A 1 28  ? -52.55200 -20.01700 -30.94100 1.000 306.72722 ? 28  CYS F SG  1 
ATOM 83   N N   . SER A 1 29  ? -50.80400 -16.55900 -33.99500 1.000 248.88550 ? 29  SER F N   1 
ATOM 84   C CA  . SER A 1 29  ? -49.40100 -16.17600 -34.13500 1.000 249.12149 ? 29  SER F CA  1 
ATOM 85   C C   . SER A 1 29  ? -49.22500 -14.65500 -34.04800 1.000 252.02347 ? 29  SER F C   1 
ATOM 86   O O   . SER A 1 29  ? -50.20500 -13.91200 -34.12100 1.000 253.45863 ? 29  SER F O   1 
ATOM 87   C CB  . SER A 1 29  ? -48.91300 -16.79500 -35.46500 1.000 248.26687 ? 29  SER F CB  1 
ATOM 88   O OG  . SER A 1 29  ? -47.52600 -16.70500 -35.68200 1.000 252.18773 ? 29  SER F OG  1 
ATOM 89   N N   . THR A 1 30  ? -47.96800 -14.16600 -33.86500 1.000 252.19928 ? 30  THR F N   1 
ATOM 90   C CA  . THR A 1 30  ? -47.73000 -12.71600 -33.89200 1.000 240.84187 ? 30  THR F CA  1 
ATOM 91   C C   . THR A 1 30  ? -46.60500 -12.33200 -34.84800 1.000 230.43645 ? 30  THR F C   1 
ATOM 92   O O   . THR A 1 30  ? -45.58400 -13.02600 -34.99100 1.000 231.64028 ? 30  THR F O   1 
ATOM 93   C CB  . THR A 1 30  ? -47.37000 -12.09900 -32.51900 1.000 234.41613 ? 30  THR F CB  1 
ATOM 94   O OG1 . THR A 1 30  ? -47.44100 -10.67600 -32.63600 1.000 233.35760 ? 30  THR F OG1 1 
ATOM 95   C CG2 . THR A 1 30  ? -45.95400 -12.43100 -32.09800 1.000 228.16079 ? 30  THR F CG2 1 
ATOM 96   N N   . ILE A 1 31  ? -46.71900 -11.09900 -35.31600 1.000 217.71274 ? 31  ILE F N   1 
ATOM 97   C CA  . ILE A 1 31  ? -45.70300 -10.42600 -36.09600 1.000 215.12978 ? 31  ILE F CA  1 
ATOM 98   C C   . ILE A 1 31  ? -45.44400 -9.03700  -35.60200 1.000 220.25035 ? 31  ILE F C   1 
ATOM 99   O O   . ILE A 1 31  ? -46.37200 -8.23800  -35.44600 1.000 219.84355 ? 31  ILE F O   1 
ATOM 100  C CB  . ILE A 1 31  ? -46.06300 -10.33600 -37.57000 1.000 219.89910 ? 31  ILE F CB  1 
ATOM 101  C CG1 . ILE A 1 31  ? -44.95100 -9.52700  -38.22300 1.000 228.55928 ? 31  ILE F CG1 1 
ATOM 102  C CG2 . ILE A 1 31  ? -47.38700 -9.65800  -37.71600 1.000 220.53357 ? 31  ILE F CG2 1 
ATOM 103  C CD1 . ILE A 1 31  ? -43.59900 -10.21200 -38.21200 1.000 224.35967 ? 31  ILE F CD1 1 
ATOM 104  N N   . THR A 1 32  ? -44.18000 -8.72500  -35.43500 1.000 224.11205 ? 32  THR F N   1 
ATOM 105  C CA  . THR A 1 32  ? -43.80600 -7.43600  -34.91300 1.000 231.90346 ? 32  THR F CA  1 
ATOM 106  C C   . THR A 1 32  ? -43.02300 -6.64600  -35.96400 1.000 229.98087 ? 32  THR F C   1 
ATOM 107  O O   . THR A 1 32  ? -41.98800 -7.13700  -36.45200 1.000 225.16988 ? 32  THR F O   1 
ATOM 108  C CB  . THR A 1 32  ? -42.97000 -7.73600  -33.67800 1.000 234.10128 ? 32  THR F CB  1 
ATOM 109  O OG1 . THR A 1 32  ? -43.70500 -8.66700  -32.86100 1.000 230.55078 ? 32  THR F OG1 1 
ATOM 110  C CG2 . THR A 1 32  ? -42.71000 -6.46700  -32.88100 1.000 239.52221 ? 32  THR F CG2 1 
ATOM 111  N N   . GLU A 1 33  ? -43.55100 -5.46000  -36.37200 1.000 229.12359 ? 33  GLU F N   1 
ATOM 112  C CA  . GLU A 1 33  ? -42.89100 -4.65000  -37.40300 1.000 227.12928 ? 33  GLU F CA  1 
ATOM 113  C C   . GLU A 1 33  ? -42.36100 -3.32000  -36.87300 1.000 221.09435 ? 33  GLU F C   1 
ATOM 114  O O   . GLU A 1 33  ? -42.66300 -2.88700  -35.75900 1.000 220.49693 ? 33  GLU F O   1 
ATOM 115  C CB  . GLU A 1 33  ? -43.83900 -4.31800  -38.56800 1.000 233.36308 ? 33  GLU F CB  1 
ATOM 116  C CG  . GLU A 1 33  ? -44.59500 -5.42500  -39.23800 1.000 234.67954 ? 33  GLU F CG  1 
ATOM 117  C CD  . GLU A 1 33  ? -43.68800 -6.10700  -40.24700 1.000 241.14097 ? 33  GLU F CD  1 
ATOM 118  O OE1 . GLU A 1 33  ? -42.61300 -5.53700  -40.55200 1.000 243.71328 ? 33  GLU F OE1 1 
ATOM 119  O OE2 . GLU A 1 33  ? -44.06300 -7.16000  -40.79200 1.000 245.11959 ? 33  GLU F OE2 1 
ATOM 120  N N   . GLY A 1 34  ? -41.53000 -2.67200  -37.69100 1.000 215.88363 ? 34  GLY F N   1 
ATOM 121  C CA  . GLY A 1 34  ? -40.98400 -1.40800  -37.25500 1.000 215.50091 ? 34  GLY F CA  1 
ATOM 122  C C   . GLY A 1 34  ? -39.58000 -1.54700  -36.73300 1.000 218.87321 ? 34  GLY F C   1 
ATOM 123  O O   . GLY A 1 34  ? -39.35700 -1.14400  -35.59200 1.000 222.41780 ? 34  GLY F O   1 
ATOM 124  N N   . TYR A 1 35  ? -38.62400 -2.08100  -37.48500 1.000 217.22827 ? 35  TYR F N   1 
ATOM 125  C CA  . TYR A 1 35  ? -37.27800 -2.18500  -36.93800 1.000 223.50152 ? 35  TYR F CA  1 
ATOM 126  C C   . TYR A 1 35  ? -36.18900 -1.60600  -37.81700 1.000 222.99932 ? 35  TYR F C   1 
ATOM 127  O O   . TYR A 1 35  ? -36.29100 -1.56600  -39.04800 1.000 223.00562 ? 35  TYR F O   1 
ATOM 128  C CB  . TYR A 1 35  ? -36.92500 -3.64100  -36.63700 1.000 229.42510 ? 35  TYR F CB  1 
ATOM 129  C CG  . TYR A 1 35  ? -37.64700 -4.10100  -35.41400 1.000 235.27169 ? 35  TYR F CG  1 
ATOM 130  C CD1 . TYR A 1 35  ? -37.15800 -3.80800  -34.14800 1.000 240.08819 ? 35  TYR F CD1 1 
ATOM 131  C CD2 . TYR A 1 35  ? -38.87200 -4.74400  -35.52000 1.000 231.34136 ? 35  TYR F CD2 1 
ATOM 132  C CE1 . TYR A 1 35  ? -37.84600 -4.19100  -33.01600 1.000 243.60364 ? 35  TYR F CE1 1 
ATOM 133  C CE2 . TYR A 1 35  ? -39.56600 -5.13300  -34.39600 1.000 233.15946 ? 35  TYR F CE2 1 
ATOM 134  C CZ  . TYR A 1 35  ? -39.05400 -4.85200  -33.14600 1.000 238.20562 ? 35  TYR F CZ  1 
ATOM 135  O OH  . TYR A 1 35  ? -39.75800 -5.24400  -32.03000 1.000 235.88993 ? 35  TYR F OH  1 
ATOM 136  N N   . LEU A 1 36  ? -35.12700 -1.18000  -37.14500 1.000 220.20596 ? 36  LEU F N   1 
ATOM 137  C CA  . LEU A 1 36  ? -33.98400 -0.59600  -37.80000 1.000 219.99598 ? 36  LEU F CA  1 
ATOM 138  C C   . LEU A 1 36  ? -32.81600 -1.52800  -37.62700 1.000 216.09647 ? 36  LEU F C   1 
ATOM 139  O O   . LEU A 1 36  ? -32.47700 -1.90700  -36.50900 1.000 214.19744 ? 36  LEU F O   1 
ATOM 140  C CB  . LEU A 1 36  ? -33.63500 0.73800   -37.17500 1.000 226.07191 ? 36  LEU F CB  1 
ATOM 141  C CG  . LEU A 1 36  ? -34.85900 1.62100   -37.26600 1.000 234.88835 ? 36  LEU F CG  1 
ATOM 142  C CD1 . LEU A 1 36  ? -34.73900 2.84400   -36.33600 1.000 241.06186 ? 36  LEU F CD1 1 
ATOM 143  C CD2 . LEU A 1 36  ? -35.06600 1.97500   -38.73700 1.000 235.82154 ? 36  LEU F CD2 1 
ATOM 144  N N   . SER A 1 37  ? -32.17400 -1.84300  -38.72100 1.000 214.78410 ? 37  SER F N   1 
ATOM 145  C CA  . SER A 1 37  ? -31.11200 -2.80500  -38.63300 1.000 209.37612 ? 37  SER F CA  1 
ATOM 146  C C   . SER A 1 37  ? -29.94900 -2.12500  -37.97100 1.000 209.08618 ? 37  SER F C   1 
ATOM 147  O O   . SER A 1 37  ? -29.79600 -0.90800  -38.03100 1.000 211.33267 ? 37  SER F O   1 
ATOM 148  C CB  . SER A 1 37  ? -30.65500 -3.28500  -39.98500 1.000 212.75289 ? 37  SER F CB  1 
ATOM 149  O OG  . SER A 1 37  ? -30.12100 -2.19100  -40.69000 1.000 215.77486 ? 37  SER F OG  1 
ATOM 150  N N   . VAL A 1 38  ? -29.17700 -2.90400  -37.26600 1.000 209.99674 ? 38  VAL F N   1 
ATOM 151  C CA  . VAL A 1 38  ? -27.84000 -2.52400  -36.93600 1.000 214.34355 ? 38  VAL F CA  1 
ATOM 152  C C   . VAL A 1 38  ? -27.13800 -3.81900  -37.28900 1.000 214.22080 ? 38  VAL F C   1 
ATOM 153  O O   . VAL A 1 38  ? -27.14500 -4.77300  -36.50600 1.000 218.32712 ? 38  VAL F O   1 
ATOM 154  C CB  . VAL A 1 38  ? -27.67500 -2.14400  -35.46000 1.000 217.83456 ? 38  VAL F CB  1 
ATOM 155  C CG1 . VAL A 1 38  ? -26.30300 -1.55800  -35.20600 1.000 217.03157 ? 38  VAL F CG1 1 
ATOM 156  C CG2 . VAL A 1 38  ? -28.79500 -1.20100  -35.00000 1.000 217.13971 ? 38  VAL F CG2 1 
ATOM 157  N N   . LEU A 1 39  ? -26.61600 -3.89700  -38.49900 1.000 209.78649 ? 39  LEU F N   1 
ATOM 158  C CA  . LEU A 1 39  ? -26.09600 -5.15500  -38.99000 1.000 208.52485 ? 39  LEU F CA  1 
ATOM 159  C C   . LEU A 1 39  ? -24.58700 -5.20300  -38.91000 1.000 201.97139 ? 39  LEU F C   1 
ATOM 160  O O   . LEU A 1 39  ? -23.90700 -4.33100  -39.45000 1.000 200.58099 ? 39  LEU F O   1 
ATOM 161  C CB  . LEU A 1 39  ? -26.59300 -5.45500  -40.39200 1.000 214.16430 ? 39  LEU F CB  1 
ATOM 162  C CG  . LEU A 1 39  ? -28.12400 -5.49200  -40.40700 1.000 213.43197 ? 39  LEU F CG  1 
ATOM 163  C CD1 . LEU A 1 39  ? -28.68900 -5.60500  -41.81300 1.000 222.04331 ? 39  LEU F CD1 1 
ATOM 164  C CD2 . LEU A 1 39  ? -28.68500 -6.55700  -39.49200 1.000 211.73635 ? 39  LEU F CD2 1 
ATOM 165  N N   . ARG A 1 40  ? -24.07500 -6.26500  -38.29800 1.000 198.19929 ? 40  ARG F N   1 
ATOM 166  C CA  . ARG A 1 40  ? -22.65200 -6.50000  -38.31900 1.000 197.04532 ? 40  ARG F CA  1 
ATOM 167  C C   . ARG A 1 40  ? -22.27000 -6.97500  -39.68500 1.000 210.22891 ? 40  ARG F C   1 
ATOM 168  O O   . ARG A 1 40  ? -22.61100 -8.09300  -40.06600 1.000 221.82784 ? 40  ARG F O   1 
ATOM 169  C CB  . ARG A 1 40  ? -22.28000 -7.60300  -37.31800 1.000 184.80533 ? 40  ARG F CB  1 
ATOM 170  C CG  . ARG A 1 40  ? -20.77000 -7.72500  -37.05800 1.000 196.91609 ? 40  ARG F CG  1 
ATOM 171  C CD  . ARG A 1 40  ? -19.81500 -8.65400  -37.98600 1.000 214.88123 ? 40  ARG F CD  1 
ATOM 172  N NE  . ARG A 1 40  ? -20.19100 -9.99700  -38.45900 1.000 219.96992 ? 40  ARG F NE  1 
ATOM 173  C CZ  . ARG A 1 40  ? -19.55700 -10.68200 -39.41900 1.000 213.84755 ? 40  ARG F CZ  1 
ATOM 174  N NH1 . ARG A 1 40  ? -18.51200 -10.19000 -40.07000 1.000 206.51769 ? 40  ARG F NH1 1 
ATOM 175  N NH2 . ARG A 1 40  ? -19.87900 -11.94600 -39.62800 1.000 207.24337 ? 40  ARG F NH2 1 
ATOM 176  N N   . THR A 1 41  ? -21.54400 -6.12600  -40.41000 1.000 210.42383 ? 41  THR F N   1 
ATOM 177  C CA  . THR A 1 41  ? -21.08700 -6.41700  -41.76300 1.000 210.17862 ? 41  THR F CA  1 
ATOM 178  C C   . THR A 1 41  ? -19.56600 -6.58800  -41.81200 1.000 213.38605 ? 41  THR F C   1 
ATOM 179  O O   . THR A 1 41  ? -19.07300 -7.27000  -42.71900 1.000 215.33180 ? 41  THR F O   1 
ATOM 180  C CB  . THR A 1 41  ? -21.59900 -5.40300  -42.82400 1.000 195.06908 ? 41  THR F CB  1 
ATOM 181  O OG1 . THR A 1 41  ? -21.44300 -4.04200  -42.40300 1.000 202.96394 ? 41  THR F OG1 1 
ATOM 182  C CG2 . THR A 1 41  ? -23.03800 -5.69700  -43.25400 1.000 199.81728 ? 41  THR F CG2 1 
ATOM 183  N N   . GLY A 1 42  ? -18.83100 -6.12500  -40.78500 1.000 213.70619 ? 42  GLY F N   1 
ATOM 184  C CA  . GLY A 1 42  ? -17.37700 -6.24700  -40.82000 1.000 211.59992 ? 42  GLY F CA  1 
ATOM 185  C C   . GLY A 1 42  ? -16.70500 -6.26600  -39.45600 1.000 215.77518 ? 42  GLY F C   1 
ATOM 186  O O   . GLY A 1 42  ? -17.36300 -6.31200  -38.41400 1.000 217.95088 ? 42  GLY F O   1 
ATOM 187  N N   . TRP A 1 43  ? -15.36200 -6.31400  -39.47800 1.000 216.18472 ? 43  TRP F N   1 
ATOM 188  C CA  . TRP A 1 43  ? -14.53100 -6.29000  -38.27100 1.000 214.79827 ? 43  TRP F CA  1 
ATOM 189  C C   . TRP A 1 43  ? -13.48700 -5.17700  -38.33500 1.000 213.22747 ? 43  TRP F C   1 
ATOM 190  O O   . TRP A 1 43  ? -12.72500 -5.08200  -39.29900 1.000 211.79429 ? 43  TRP F O   1 
ATOM 191  C CB  . TRP A 1 43  ? -13.84800 -7.64700  -38.07800 1.000 213.18832 ? 43  TRP F CB  1 
ATOM 192  C CG  . TRP A 1 43  ? -14.86200 -8.69500  -37.90800 1.000 216.39460 ? 43  TRP F CG  1 
ATOM 193  C CD1 . TRP A 1 43  ? -15.26200 -9.63200  -38.82600 1.000 217.71906 ? 43  TRP F CD1 1 
ATOM 194  C CD2 . TRP A 1 43  ? -15.71100 -8.84300  -36.78100 1.000 214.21918 ? 43  TRP F CD2 1 
ATOM 195  N NE1 . TRP A 1 43  ? -16.27800 -10.39500 -38.30400 1.000 219.52055 ? 43  TRP F NE1 1 
ATOM 196  C CE2 . TRP A 1 43  ? -16.57500 -9.92200  -37.05100 1.000 222.08587 ? 43  TRP F CE2 1 
ATOM 197  C CE3 . TRP A 1 43  ? -15.81000 -8.17900  -35.55100 1.000 202.72105 ? 43  TRP F CE3 1 
ATOM 198  C CZ2 . TRP A 1 43  ? -17.52000 -10.34800 -36.13800 1.000 225.05700 ? 43  TRP F CZ2 1 
ATOM 199  C CZ3 . TRP A 1 43  ? -16.73700 -8.60600  -34.65000 1.000 200.28184 ? 43  TRP F CZ3 1 
ATOM 200  C CH2 . TRP A 1 43  ? -17.59100 -9.67200  -34.94700 1.000 215.80895 ? 43  TRP F CH2 1 
ATOM 201  N N   . TYR A 1 44  ? -13.41700 -4.38600  -37.27100 1.000 213.97313 ? 44  TYR F N   1 
ATOM 202  C CA  . TYR A 1 44  ? -12.40100 -3.36700  -37.06100 1.000 214.36233 ? 44  TYR F CA  1 
ATOM 203  C C   . TYR A 1 44  ? -11.35900 -3.83200  -36.06400 1.000 215.80770 ? 44  TYR F C   1 
ATOM 204  O O   . TYR A 1 44  ? -11.70300 -4.29400  -34.97000 1.000 216.15081 ? 44  TYR F O   1 
ATOM 205  C CB  . TYR A 1 44  ? -13.02700 -2.09100  -36.50300 1.000 211.20988 ? 44  TYR F CB  1 
ATOM 206  C CG  . TYR A 1 44  ? -12.09100 -0.91100  -36.51400 1.000 212.89153 ? 44  TYR F CG  1 
ATOM 207  C CD1 . TYR A 1 44  ? -11.49200 -0.49600  -37.68300 1.000 213.70810 ? 44  TYR F CD1 1 
ATOM 208  C CD2 . TYR A 1 44  ? -11.71400 -0.28300  -35.32300 1.000 213.02836 ? 44  TYR F CD2 1 
ATOM 209  C CE1 . TYR A 1 44  ? -10.61400 0.56000   -37.69000 1.000 217.81755 ? 44  TYR F CE1 1 
ATOM 210  C CE2 . TYR A 1 44  ? -10.82200 0.77200   -35.31700 1.000 216.58275 ? 44  TYR F CE2 1 
ATOM 211  C CZ  . TYR A 1 44  ? -10.27700 1.18600   -36.50800 1.000 220.89873 ? 44  TYR F CZ  1 
ATOM 212  O OH  . TYR A 1 44  ? -9.39800  2.23600   -36.54300 1.000 227.53417 ? 44  TYR F OH  1 
ATOM 213  N N   . THR A 1 45  ? -10.09300 -3.69700  -36.42600 1.000 217.63367 ? 45  THR F N   1 
ATOM 214  C CA  . THR A 1 45  ? -9.02100  -4.22400  -35.60200 1.000 215.10431 ? 45  THR F CA  1 
ATOM 215  C C   . THR A 1 45  ? -8.35300  -3.08100  -34.84800 1.000 213.18800 ? 45  THR F C   1 
ATOM 216  O O   . THR A 1 45  ? -7.80300  -2.14000  -35.46600 1.000 212.00757 ? 45  THR F O   1 
ATOM 217  C CB  . THR A 1 45  ? -8.00200  -4.96700  -36.45100 1.000 216.08791 ? 45  THR F CB  1 
ATOM 218  O OG1 . THR A 1 45  ? -8.65700  -6.03700  -37.14400 1.000 221.39833 ? 45  THR F OG1 1 
ATOM 219  C CG2 . THR A 1 45  ? -6.86600  -5.48900  -35.56300 1.000 211.35959 ? 45  THR F CG2 1 
ATOM 220  N N   . ASN A 1 46  ? -8.36600  -3.17900  -33.51000 1.000 213.96756 ? 46  ASN F N   1 
ATOM 221  C CA  . ASN A 1 46  ? -7.69000  -2.19100  -32.68800 1.000 217.90109 ? 46  ASN F CA  1 
ATOM 222  C C   . ASN A 1 46  ? -6.56100  -2.95900  -32.02000 1.000 210.72804 ? 46  ASN F C   1 
ATOM 223  O O   . ASN A 1 46  ? -6.79500  -3.78700  -31.13600 1.000 212.96189 ? 46  ASN F O   1 
ATOM 224  C CB  . ASN A 1 46  ? -8.64400  -1.58000  -31.65000 1.000 220.66267 ? 46  ASN F CB  1 
ATOM 225  C CG  . ASN A 1 46  ? -8.09600  -0.29300  -31.00800 1.000 220.14876 ? 46  ASN F CG  1 
ATOM 226  O OD1 . ASN A 1 46  ? -8.64000  0.20800   -30.02400 1.000 216.88072 ? 46  ASN F OD1 1 
ATOM 227  N ND2 . ASN A 1 46  ? -7.07100  0.28000   -31.61700 1.000 221.45927 ? 46  ASN F ND2 1 
ATOM 228  N N   . VAL A 1 47  ? -5.35000  -2.69200  -32.43400 1.000 202.50327 ? 47  VAL F N   1 
ATOM 229  C CA  . VAL A 1 47  ? -4.20200  -3.35100  -31.86100 1.000 193.69096 ? 47  VAL F CA  1 
ATOM 230  C C   . VAL A 1 47  ? -3.65800  -2.46000  -30.76000 1.000 201.70384 ? 47  VAL F C   1 
ATOM 231  O O   . VAL A 1 47  ? -3.36400  -1.27700  -30.99500 1.000 198.04283 ? 47  VAL F O   1 
ATOM 232  C CB  . VAL A 1 47  ? -3.15800  -3.65500  -32.92800 1.000 178.49864 ? 47  VAL F CB  1 
ATOM 233  C CG1 . VAL A 1 47  ? -2.04600  -4.37600  -32.28500 1.000 181.89817 ? 47  VAL F CG1 1 
ATOM 234  C CG2 . VAL A 1 47  ? -3.79800  -4.48600  -33.97800 1.000 178.24310 ? 47  VAL F CG2 1 
ATOM 235  N N   . PHE A 1 48  ? -3.37300  -3.04700  -29.61200 1.000 210.54231 ? 48  PHE F N   1 
ATOM 236  C CA  . PHE A 1 48  ? -2.87300  -2.28300  -28.49400 1.000 214.14735 ? 48  PHE F CA  1 
ATOM 237  C C   . PHE A 1 48  ? -1.44500  -2.76800  -28.29100 1.000 215.21771 ? 48  PHE F C   1 
ATOM 238  O O   . PHE A 1 48  ? -1.16900  -3.97900  -28.35400 1.000 214.67035 ? 48  PHE F O   1 
ATOM 239  C CB  . PHE A 1 48  ? -3.72100  -2.49200  -27.21900 1.000 213.43693 ? 48  PHE F CB  1 
ATOM 240  C CG  . PHE A 1 48  ? -5.08300  -1.78200  -27.21600 1.000 210.90396 ? 48  PHE F CG  1 
ATOM 241  C CD1 . PHE A 1 48  ? -6.17000  -2.28900  -27.91300 1.000 207.17646 ? 48  PHE F CD1 1 
ATOM 242  C CD2 . PHE A 1 48  ? -5.24000  -0.56800  -26.54200 1.000 211.76072 ? 48  PHE F CD2 1 
ATOM 243  C CE1 . PHE A 1 48  ? -7.39800  -1.62500  -27.88900 1.000 203.11635 ? 48  PHE F CE1 1 
ATOM 244  C CE2 . PHE A 1 48  ? -6.45600  0.10600   -26.53000 1.000 203.27777 ? 48  PHE F CE2 1 
ATOM 245  C CZ  . PHE A 1 48  ? -7.52800  -0.41900  -27.20400 1.000 201.34915 ? 48  PHE F CZ  1 
ATOM 246  N N   . THR A 1 49  ? -0.56200  -1.81700  -27.96400 1.000 215.27302 ? 49  THR F N   1 
ATOM 247  C CA  . THR A 1 49  ? 0.80700   -2.06600  -27.51000 1.000 213.51144 ? 49  THR F CA  1 
ATOM 248  C C   . THR A 1 49  ? 1.09500   -1.50000  -26.11800 1.000 213.87206 ? 49  THR F C   1 
ATOM 249  O O   . THR A 1 49  ? 1.11300   -0.28100  -25.92500 1.000 224.68416 ? 49  THR F O   1 
ATOM 250  C CB  . THR A 1 49  ? 1.75400   -1.49100  -28.56000 1.000 220.94591 ? 49  THR F CB  1 
ATOM 251  O OG1 . THR A 1 49  ? 1.63400   -0.06800  -28.56400 1.000 232.81323 ? 49  THR F OG1 1 
ATOM 252  C CG2 . THR A 1 49  ? 1.34300   -1.96100  -29.94700 1.000 217.12957 ? 49  THR F CG2 1 
ATOM 253  N N   . LEU A 1 50  ? 1.18500   -2.38600  -25.13400 1.000 206.33551 ? 50  LEU F N   1 
ATOM 254  C CA  . LEU A 1 50  ? 1.50300   -2.06000  -23.74800 1.000 210.01564 ? 50  LEU F CA  1 
ATOM 255  C C   . LEU A 1 50  ? 2.99800   -2.13700  -23.42500 1.000 218.22682 ? 50  LEU F C   1 
ATOM 256  O O   . LEU A 1 50  ? 3.57200   -3.22400  -23.41900 1.000 220.58533 ? 50  LEU F O   1 
ATOM 257  C CB  . LEU A 1 50  ? 0.74300   -2.99900  -22.82500 1.000 212.90937 ? 50  LEU F CB  1 
ATOM 258  C CG  . LEU A 1 50  ? 0.64500   -2.59900  -21.36100 1.000 227.75937 ? 50  LEU F CG  1 
ATOM 259  C CD1 . LEU A 1 50  ? -0.56100  -3.34300  -20.76200 1.000 228.03522 ? 50  LEU F CD1 1 
ATOM 260  C CD2 . LEU A 1 50  ? 1.94300   -2.81700  -20.54700 1.000 234.68645 ? 50  LEU F CD2 1 
ATOM 261  N N   . GLU A 1 51  ? 3.65000   -1.00900  -23.17700 1.000 222.83687 ? 51  GLU F N   1 
ATOM 262  C CA  . GLU A 1 51  ? 5.07600   -1.07400  -22.86200 1.000 228.99291 ? 51  GLU F CA  1 
ATOM 263  C C   . GLU A 1 51  ? 5.22900   -1.45000  -21.39600 1.000 232.59743 ? 51  GLU F C   1 
ATOM 264  O O   . GLU A 1 51  ? 4.65100   -0.80300  -20.51700 1.000 235.25005 ? 51  GLU F O   1 
ATOM 265  C CB  . GLU A 1 51  ? 5.87000   0.22900   -23.07700 1.000 237.34006 ? 51  GLU F CB  1 
ATOM 266  C CG  . GLU A 1 51  ? 6.13300   1.04300   -24.39600 1.000 235.54273 ? 51  GLU F CG  1 
ATOM 267  C CD  . GLU A 1 51  ? 7.25000   0.46000   -25.33500 1.000 237.21802 ? 51  GLU F CD  1 
ATOM 268  O OE1 . GLU A 1 51  ? 7.92300   -0.54400  -24.97500 1.000 238.40177 ? 51  GLU F OE1 1 
ATOM 269  O OE2 . GLU A 1 51  ? 7.53500   1.08500   -26.39200 1.000 234.52435 ? 51  GLU F OE2 1 
ATOM 270  N N   . VAL A 1 52  ? 5.93700   -2.55400  -21.15400 1.000 230.55868 ? 52  VAL F N   1 
ATOM 271  C CA  . VAL A 1 52  ? 6.22600   -3.03600  -19.80600 1.000 236.84201 ? 52  VAL F CA  1 
ATOM 272  C C   . VAL A 1 52  ? 7.56300   -2.45000  -19.34500 1.000 253.14239 ? 52  VAL F C   1 
ATOM 273  O O   . VAL A 1 52  ? 7.73300   -2.12600  -18.16600 1.000 256.86631 ? 52  VAL F O   1 
ATOM 274  C CB  . VAL A 1 52  ? 6.23600   -4.57200  -19.77100 1.000 226.55115 ? 52  VAL F CB  1 
ATOM 275  C CG1 . VAL A 1 52  ? 6.68900   -5.07400  -18.42800 1.000 236.27077 ? 52  VAL F CG1 1 
ATOM 276  C CG2 . VAL A 1 52  ? 4.87000   -5.05800  -19.99300 1.000 222.96896 ? 52  VAL F CG2 1 
ATOM 277  N N   . GLY A 1 53  ? 8.49700   -2.29000  -20.27800 1.000 259.32245 ? 53  GLY F N   1 
ATOM 278  C CA  . GLY A 1 53  ? 9.84300   -1.76400  -20.11600 1.000 257.98462 ? 53  GLY F CA  1 
ATOM 279  C C   . GLY A 1 53  ? 10.91000  -2.80700  -19.99200 1.000 256.47277 ? 53  GLY F C   1 
ATOM 280  O O   . GLY A 1 53  ? 10.65900  -4.01400  -19.93000 1.000 258.81652 ? 53  GLY F O   1 
ATOM 281  N N   . ASP A 1 54  ? 12.13400  -2.32600  -19.87300 1.000 253.22897 ? 54  ASP F N   1 
ATOM 282  C CA  . ASP A 1 54  ? 13.17200  -3.32800  -19.76400 1.000 253.18089 ? 54  ASP F CA  1 
ATOM 283  C C   . ASP A 1 54  ? 13.10400  -3.58500  -18.25500 1.000 242.35080 ? 54  ASP F C   1 
ATOM 284  O O   . ASP A 1 54  ? 13.57200  -2.79600  -17.42500 1.000 235.48868 ? 54  ASP F O   1 
ATOM 285  C CB  . ASP A 1 54  ? 14.48400  -2.87600  -20.40200 1.000 257.95710 ? 54  ASP F CB  1 
ATOM 286  C CG  . ASP A 1 54  ? 15.45300  -4.04800  -20.63500 1.000 253.64220 ? 54  ASP F CG  1 
ATOM 287  O OD1 . ASP A 1 54  ? 15.15700  -5.15900  -20.16900 1.000 255.75665 ? 54  ASP F OD1 1 
ATOM 288  O OD2 . ASP A 1 54  ? 16.41200  -3.91900  -21.43300 1.000 246.44456 ? 54  ASP F OD2 1 
ATOM 289  N N   . VAL A 1 55  ? 12.26200  -4.56300  -17.93000 1.000 237.09087 ? 55  VAL F N   1 
ATOM 290  C CA  . VAL A 1 55  ? 12.00100  -4.99400  -16.56600 1.000 228.69496 ? 55  VAL F CA  1 
ATOM 291  C C   . VAL A 1 55  ? 12.65300  -6.32400  -16.23100 1.000 236.29056 ? 55  VAL F C   1 
ATOM 292  O O   . VAL A 1 55  ? 12.73900  -6.67300  -15.04300 1.000 238.00974 ? 55  VAL F O   1 
ATOM 293  C CB  . VAL A 1 55  ? 10.48500  -5.12300  -16.36600 1.000 229.02842 ? 55  VAL F CB  1 
ATOM 294  C CG1 . VAL A 1 55  ? 9.86000   -3.80200  -16.52500 1.000 234.35183 ? 55  VAL F CG1 1 
ATOM 295  C CG2 . VAL A 1 55  ? 9.93100   -6.13500  -17.36600 1.000 238.66812 ? 55  VAL F CG2 1 
ATOM 296  N N   . GLU A 1 56  ? 12.98200  -7.13100  -17.23100 1.000 239.34235 ? 56  GLU F N   1 
ATOM 297  C CA  . GLU A 1 56  ? 13.69000  -8.38500  -17.01100 1.000 244.39531 ? 56  GLU F CA  1 
ATOM 298  C C   . GLU A 1 56  ? 15.09400  -8.15600  -16.43500 1.000 250.10199 ? 56  GLU F C   1 
ATOM 299  O O   . GLU A 1 56  ? 15.56800  -8.98300  -15.64700 1.000 250.11992 ? 56  GLU F O   1 
ATOM 300  C CB  . GLU A 1 56  ? 13.64200  -9.21900  -18.29000 1.000 247.24269 ? 56  GLU F CB  1 
ATOM 301  C CG  . GLU A 1 56  ? 14.23000  -8.52500  -19.50100 1.000 257.36795 ? 56  GLU F CG  1 
ATOM 302  C CD  . GLU A 1 56  ? 13.21000  -7.57700  -20.19000 1.000 252.55427 ? 56  GLU F CD  1 
ATOM 303  O OE1 . GLU A 1 56  ? 12.37900  -6.95800  -19.47700 1.000 248.89979 ? 56  GLU F OE1 1 
ATOM 304  O OE2 . GLU A 1 56  ? 13.26900  -7.41700  -21.43800 1.000 249.92949 ? 56  GLU F OE2 1 
ATOM 305  N N   . ASN A 1 57  ? 15.82900  -7.11500  -16.90200 1.000 252.09974 ? 57  ASN F N   1 
ATOM 306  C CA  . ASN A 1 57  ? 17.20100  -6.82500  -16.43400 1.000 251.75093 ? 57  ASN F CA  1 
ATOM 307  C C   . ASN A 1 57  ? 17.24800  -6.12700  -15.06800 1.000 255.79900 ? 57  ASN F C   1 
ATOM 308  O O   . ASN A 1 57  ? 18.31500  -5.60800  -14.70900 1.000 256.88218 ? 57  ASN F O   1 
ATOM 309  C CB  . ASN A 1 57  ? 17.99100  -5.90100  -17.39700 1.000 249.74509 ? 57  ASN F CB  1 
ATOM 310  C CG  . ASN A 1 57  ? 18.44300  -6.57100  -18.67600 1.000 244.69041 ? 57  ASN F CG  1 
ATOM 311  O OD1 . ASN A 1 57  ? 17.96200  -7.63200  -19.02000 1.000 248.83479 ? 57  ASN F OD1 1 
ATOM 312  N ND2 . ASN A 1 57  ? 19.36700  -5.92700  -19.40300 1.000 237.15056 ? 57  ASN F ND2 1 
ATOM 313  N N   . LEU A 1 58  ? 16.12900  -6.03400  -14.34600 1.000 258.43979 ? 58  LEU F N   1 
ATOM 314  C CA  . LEU A 1 58  ? 16.09400  -5.54100  -12.97100 1.000 259.07065 ? 58  LEU F CA  1 
ATOM 315  C C   . LEU A 1 58  ? 15.94600  -6.74700  -12.03300 1.000 262.40825 ? 58  LEU F C   1 
ATOM 316  O O   . LEU A 1 58  ? 15.16900  -7.66700  -12.30900 1.000 260.07554 ? 58  LEU F O   1 
ATOM 317  C CB  . LEU A 1 58  ? 14.95800  -4.51000  -12.80800 1.000 250.23235 ? 58  LEU F CB  1 
ATOM 318  C CG  . LEU A 1 58  ? 15.16500  -3.18100  -13.58200 1.000 244.22025 ? 58  LEU F CG  1 
ATOM 319  C CD1 . LEU A 1 58  ? 14.05700  -2.15900  -13.38300 1.000 242.03891 ? 58  LEU F CD1 1 
ATOM 320  C CD2 . LEU A 1 58  ? 16.48900  -2.53900  -13.18900 1.000 245.16923 ? 58  LEU F CD2 1 
ATOM 321  N N   . THR A 1 59  ? 16.71400  -6.74900  -10.94100 1.000 268.91732 ? 59  THR F N   1 
ATOM 322  C CA  . THR A 1 59  ? 16.76900  -7.81900  -9.93800  1.000 275.86370 ? 59  THR F CA  1 
ATOM 323  C C   . THR A 1 59  ? 16.87700  -7.18800  -8.56200  1.000 287.95304 ? 59  THR F C   1 
ATOM 324  O O   . THR A 1 59  ? 17.52200  -6.14900  -8.38600  1.000 287.91096 ? 59  THR F O   1 
ATOM 325  C CB  . THR A 1 59  ? 17.88800  -8.87600  -10.07300 1.000 272.38198 ? 59  THR F CB  1 
ATOM 326  O OG1 . THR A 1 59  ? 19.15100  -8.25500  -10.33200 1.000 283.28956 ? 59  THR F OG1 1 
ATOM 327  C CG2 . THR A 1 59  ? 17.54000  -9.94300  -11.11400 1.000 256.72211 ? 59  THR F CG2 1 
ATOM 328  N N   . CYS A 1 60  ? 16.26200  -7.84100  -7.58400  1.000 294.36291 ? 60  CYS F N   1 
ATOM 329  C CA  . CYS A 1 60  ? 16.36300  -7.41500  -6.19600  1.000 292.81398 ? 60  CYS F CA  1 
ATOM 330  C C   . CYS A 1 60  ? 17.18300  -8.45000  -5.44500  1.000 287.16173 ? 60  CYS F C   1 
ATOM 331  O O   . CYS A 1 60  ? 16.81200  -9.62700  -5.34900  1.000 284.55382 ? 60  CYS F O   1 
ATOM 332  C CB  . CYS A 1 60  ? 15.00300  -7.23900  -5.51500  1.000 286.69779 ? 60  CYS F CB  1 
ATOM 333  S SG  . CYS A 1 60  ? 13.79200  -6.02700  -6.13400  1.000 285.99820 ? 60  CYS F SG  1 
ATOM 334  N N   . ALA A 1 61  ? 18.32900  -7.97200  -4.95600  1.000 285.44640 ? 61  ALA F N   1 
ATOM 335  C CA  . ALA A 1 61  ? 19.36900  -8.71200  -4.27300  1.000 285.35035 ? 61  ALA F CA  1 
ATOM 336  C C   . ALA A 1 61  ? 19.48100  -8.34700  -2.79500  1.000 298.33543 ? 61  ALA F C   1 
ATOM 337  O O   . ALA A 1 61  ? 20.36000  -8.89600  -2.11700  1.000 309.25490 ? 61  ALA F O   1 
ATOM 338  C CB  . ALA A 1 61  ? 20.71300  -8.50600  -4.98200  1.000 273.66209 ? 61  ALA F CB  1 
ATOM 339  N N   . ASP A 1 62  ? 18.64700  -7.41700  -2.27700  1.000 294.25598 ? 62  ASP F N   1 
ATOM 340  C CA  . ASP A 1 62  ? 18.74000  -6.99600  -0.86700  1.000 291.83169 ? 62  ASP F CA  1 
ATOM 341  C C   . ASP A 1 62  ? 17.79200  -7.84800  -0.04400  1.000 295.14446 ? 62  ASP F C   1 
ATOM 342  O O   . ASP A 1 62  ? 17.08600  -7.36200  0.84900   1.000 284.90300 ? 62  ASP F O   1 
ATOM 343  C CB  . ASP A 1 62  ? 18.40600  -5.51600  -0.63800  1.000 271.10308 ? 62  ASP F CB  1 
ATOM 344  C CG  . ASP A 1 62  ? 17.00300  -5.13300  -1.09700  1.000 262.45913 ? 62  ASP F CG  1 
ATOM 345  O OD1 . ASP A 1 62  ? 16.66200  -5.31700  -2.26900  1.000 265.51939 ? 62  ASP F OD1 1 
ATOM 346  O OD2 . ASP A 1 62  ? 16.20800  -4.69900  -0.24700  1.000 260.98950 ? 62  ASP F OD2 1 
ATOM 347  N N   . GLY A 1 63  ? 17.68600  -9.11400  -0.46200  1.000 299.05800 ? 63  GLY F N   1 
ATOM 348  C CA  . GLY A 1 63  ? 16.95500  -10.15300 0.21900   1.000 293.22301 ? 63  GLY F CA  1 
ATOM 349  C C   . GLY A 1 63  ? 15.50800  -10.07500 -0.18100  1.000 279.91310 ? 63  GLY F C   1 
ATOM 350  O O   . GLY A 1 63  ? 15.14400  -9.50100  -1.21300  1.000 273.93945 ? 63  GLY F O   1 
ATOM 351  N N   . PRO A 1 64  ? 14.65000  -10.66000 0.64000   1.000 277.58737 ? 64  PRO F N   1 
ATOM 352  C CA  . PRO A 1 64  ? 13.21800  -10.63900 0.33200   1.000 273.56778 ? 64  PRO F CA  1 
ATOM 353  C C   . PRO A 1 64  ? 12.67100  -9.23800  0.58500   1.000 266.04351 ? 64  PRO F C   1 
ATOM 354  O O   . PRO A 1 64  ? 13.08500  -8.54800  1.51900   1.000 262.19471 ? 64  PRO F O   1 
ATOM 355  C CB  . PRO A 1 64  ? 12.63700  -11.70400 1.26500   1.000 276.61771 ? 64  PRO F CB  1 
ATOM 356  C CG  . PRO A 1 64  ? 13.83100  -12.62200 1.56200   1.000 276.18252 ? 64  PRO F CG  1 
ATOM 357  C CD  . PRO A 1 64  ? 15.02100  -11.72200 1.59200   1.000 278.65333 ? 64  PRO F CD  1 
ATOM 358  N N   . SER A 1 65  ? 11.76000  -8.80400  -0.28100  1.000 264.22017 ? 65  SER F N   1 
ATOM 359  C CA  . SER A 1 65  ? 11.25700  -7.44400  -0.19900  1.000 266.44825 ? 65  SER F CA  1 
ATOM 360  C C   . SER A 1 65  ? 9.85400   -7.39800  -0.79400  1.000 265.46119 ? 65  SER F C   1 
ATOM 361  O O   . SER A 1 65  ? 9.45800   -8.28800  -1.55300  1.000 263.50725 ? 65  SER F O   1 
ATOM 362  C CB  . SER A 1 65  ? 12.25000  -6.52200  -0.94200  1.000 265.26289 ? 65  SER F CB  1 
ATOM 363  O OG  . SER A 1 65  ? 11.86600  -5.16400  -1.01800  1.000 270.38560 ? 65  SER F OG  1 
ATOM 364  N N   . LEU A 1 66  ? 9.07200   -6.38100  -0.39100  1.000 267.79854 ? 66  LEU F N   1 
ATOM 365  C CA  . LEU A 1 66  ? 7.79600   -6.11700  -1.06600  1.000 260.01215 ? 66  LEU F CA  1 
ATOM 366  C C   . LEU A 1 66  ? 8.01500   -5.71000  -2.52000  1.000 253.48965 ? 66  LEU F C   1 
ATOM 367  O O   . LEU A 1 66  ? 7.30900   -6.17800  -3.41800  1.000 251.90416 ? 66  LEU F O   1 
ATOM 368  C CB  . LEU A 1 66  ? 6.93900   -5.09500  -0.29900  1.000 254.00182 ? 66  LEU F CB  1 
ATOM 369  C CG  . LEU A 1 66  ? 6.46000   -5.61900  1.07900   1.000 255.46541 ? 66  LEU F CG  1 
ATOM 370  C CD1 . LEU A 1 66  ? 5.66600   -4.61100  1.92500   1.000 256.60897 ? 66  LEU F CD1 1 
ATOM 371  C CD2 . LEU A 1 66  ? 5.70800   -6.92500  0.94700   1.000 254.93789 ? 66  LEU F CD2 1 
ATOM 372  N N   . ILE A 1 67  ? 8.93600   -4.78600  -2.77700  1.000 250.86969 ? 67  ILE F N   1 
ATOM 373  C CA  . ILE A 1 67  ? 9.15400   -4.45300  -4.17500  1.000 247.25835 ? 67  ILE F CA  1 
ATOM 374  C C   . ILE A 1 67  ? 9.71400   -5.67900  -4.89100  1.000 249.64249 ? 67  ILE F C   1 
ATOM 375  O O   . ILE A 1 67  ? 9.44200   -5.89100  -6.07400  1.000 244.87189 ? 67  ILE F O   1 
ATOM 376  C CB  . ILE A 1 67  ? 9.99600   -3.18900  -4.34600  1.000 247.28499 ? 67  ILE F CB  1 
ATOM 377  C CG1 . ILE A 1 67  ? 9.15800   -2.00600  -3.86400  1.000 240.92280 ? 67  ILE F CG1 1 
ATOM 378  C CG2 . ILE A 1 67  ? 10.30000  -2.97000  -5.81800  1.000 243.67202 ? 67  ILE F CG2 1 
ATOM 379  C CD1 . ILE A 1 67  ? 9.65900   -0.65800  -4.28500  1.000 246.23735 ? 67  ILE F CD1 1 
ATOM 380  N N   . LYS A 1 68  ? 10.58600  -6.45400  -4.21700  1.000 255.79897 ? 68  LYS F N   1 
ATOM 381  C CA  . LYS A 1 68  ? 11.09000  -7.70100  -4.81000  1.000 257.69713 ? 68  LYS F CA  1 
ATOM 382  C C   . LYS A 1 68  ? 9.98200   -8.69400  -5.09800  1.000 252.26543 ? 68  LYS F C   1 
ATOM 383  O O   . LYS A 1 68  ? 9.98900   -9.35500  -6.13800  1.000 249.46472 ? 68  LYS F O   1 
ATOM 384  C CB  . LYS A 1 68  ? 12.08700  -8.41400  -3.89400  1.000 262.68968 ? 68  LYS F CB  1 
ATOM 385  C CG  . LYS A 1 68  ? 12.90800  -9.46500  -4.66200  1.000 265.80916 ? 68  LYS F CG  1 
ATOM 386  C CD  . LYS A 1 68  ? 13.48300  -10.62700 -3.84100  1.000 270.19132 ? 68  LYS F CD  1 
ATOM 387  C CE  . LYS A 1 68  ? 12.42400  -11.53400 -3.22000  1.000 275.17212 ? 68  LYS F CE  1 
ATOM 388  N NZ  . LYS A 1 68  ? 13.02700  -12.52000 -2.25000  1.000 284.60981 ? 68  LYS F NZ  1 
ATOM 389  N N   . THR A 1 69  ? 9.06200   -8.86800  -4.15900  1.000 252.43688 ? 69  THR F N   1 
ATOM 390  C CA  . THR A 1 69  ? 7.94700   -9.76400  -4.41500  1.000 245.12171 ? 69  THR F CA  1 
ATOM 391  C C   . THR A 1 69  ? 7.14000   -9.25900  -5.61600  1.000 241.16287 ? 69  THR F C   1 
ATOM 392  O O   . THR A 1 69  ? 6.73700   -10.06100 -6.46100  1.000 231.93260 ? 69  THR F O   1 
ATOM 393  C CB  . THR A 1 69  ? 7.14400   -10.03400 -3.14100  1.000 245.29237 ? 69  THR F CB  1 
ATOM 394  O OG1 . THR A 1 69  ? 6.76400   -8.80200  -2.52500  1.000 258.38405 ? 69  THR F OG1 1 
ATOM 395  C CG2 . THR A 1 69  ? 7.95000   -10.93300 -2.16400  1.000 234.86244 ? 69  THR F CG2 1 
ATOM 396  N N   . GLU A 1 70  ? 6.89600   -7.93000  -5.71700  1.000 247.29884 ? 70  GLU F N   1 
ATOM 397  C CA  . GLU A 1 70  ? 6.18500   -7.37200  -6.88200  1.000 244.79450 ? 70  GLU F CA  1 
ATOM 398  C C   . GLU A 1 70  ? 6.97600   -7.53400  -8.17000  1.000 240.03909 ? 70  GLU F C   1 
ATOM 399  O O   . GLU A 1 70  ? 6.40400   -7.80100  -9.23200  1.000 236.23628 ? 70  GLU F O   1 
ATOM 400  C CB  . GLU A 1 70  ? 5.91200   -5.85200  -6.72900  1.000 244.48588 ? 70  GLU F CB  1 
ATOM 401  C CG  . GLU A 1 70  ? 4.77800   -5.20300  -5.85300  1.000 248.22382 ? 70  GLU F CG  1 
ATOM 402  C CD  . GLU A 1 70  ? 3.34800   -5.67800  -6.20200  1.000 250.70224 ? 70  GLU F CD  1 
ATOM 403  O OE1 . GLU A 1 70  ? 3.07600   -5.89900  -7.39900  1.000 246.42116 ? 70  GLU F OE1 1 
ATOM 404  O OE2 . GLU A 1 70  ? 2.47400   -5.75500  -5.30600  1.000 256.85703 ? 70  GLU F OE2 1 
ATOM 405  N N   . LEU A 1 71  ? 8.29100   -7.42400  -8.10100  1.000 241.26663 ? 71  LEU F N   1 
ATOM 406  C CA  . LEU A 1 71  ? 9.06500   -7.61400  -9.31200  1.000 237.21261 ? 71  LEU F CA  1 
ATOM 407  C C   . LEU A 1 71  ? 9.05500   -9.07400  -9.73400  1.000 232.75926 ? 71  LEU F C   1 
ATOM 408  O O   . LEU A 1 71  ? 8.89700   -9.38000  -10.92200 1.000 225.96749 ? 71  LEU F O   1 
ATOM 409  C CB  . LEU A 1 71  ? 10.47900  -7.11400  -9.06400  1.000 242.22292 ? 71  LEU F CB  1 
ATOM 410  C CG  . LEU A 1 71  ? 11.44300  -7.07300  -10.23300 1.000 244.60724 ? 71  LEU F CG  1 
ATOM 411  C CD1 . LEU A 1 71  ? 10.96600  -6.12500  -11.29300 1.000 244.63844 ? 71  LEU F CD1 1 
ATOM 412  C CD2 . LEU A 1 71  ? 12.78100  -6.62900  -9.69200  1.000 251.85514 ? 71  LEU F CD2 1 
ATOM 413  N N   . ASP A 1 72  ? 9.13800   -9.98500  -8.75900  1.000 235.53706 ? 72  ASP F N   1 
ATOM 414  C CA  . ASP A 1 72  ? 9.11400   -11.41000 -9.05000  1.000 233.30605 ? 72  ASP F CA  1 
ATOM 415  C C   . ASP A 1 72  ? 7.73200   -11.83100 -9.54100  1.000 222.48959 ? 72  ASP F C   1 
ATOM 416  O O   . ASP A 1 72  ? 7.61300   -12.67400 -10.43000 1.000 220.60221 ? 72  ASP F O   1 
ATOM 417  C CB  . ASP A 1 72  ? 9.58500   -12.18500 -7.80800  1.000 240.35093 ? 72  ASP F CB  1 
ATOM 418  C CG  . ASP A 1 72  ? 11.11700  -12.02200 -7.52600  1.000 243.50313 ? 72  ASP F CG  1 
ATOM 419  O OD1 . ASP A 1 72  ? 11.83400  -11.33500 -8.28500  1.000 244.94727 ? 72  ASP F OD1 1 
ATOM 420  O OD2 . ASP A 1 72  ? 11.60300  -12.55600 -6.50800  1.000 243.13003 ? 72  ASP F OD2 1 
ATOM 421  N N   . LEU A 1 73  ? 6.67600   -11.27400 -8.95200  1.000 219.02816 ? 73  LEU F N   1 
ATOM 422  C CA  . LEU A 1 73  ? 5.33500   -11.49400 -9.47100  1.000 223.09258 ? 73  LEU F CA  1 
ATOM 423  C C   . LEU A 1 73  ? 5.20100   -10.96800 -10.89200 1.000 226.00521 ? 73  LEU F C   1 
ATOM 424  O O   . LEU A 1 73  ? 4.60800   -11.62400 -11.75100 1.000 231.11007 ? 73  LEU F O   1 
ATOM 425  C CB  . LEU A 1 73  ? 4.29900   -10.85800 -8.55200  1.000 228.09910 ? 73  LEU F CB  1 
ATOM 426  C CG  . LEU A 1 73  ? 4.04900   -11.58400 -7.23000  1.000 227.31762 ? 73  LEU F CG  1 
ATOM 427  C CD1 . LEU A 1 73  ? 3.11800   -10.79000 -6.31400  1.000 231.49060 ? 73  LEU F CD1 1 
ATOM 428  C CD2 . LEU A 1 73  ? 3.42800   -12.94700 -7.55200  1.000 229.06974 ? 73  LEU F CD2 1 
ATOM 429  N N   . THR A 1 74  ? 5.75000   -9.78900  -11.16600 1.000 223.52338 ? 74  THR F N   1 
ATOM 430  C CA  . THR A 1 74  ? 5.56500   -9.20500  -12.48200 1.000 221.94794 ? 74  THR F CA  1 
ATOM 431  C C   . THR A 1 74  ? 6.31700   -10.01200 -13.50800 1.000 219.86891 ? 74  THR F C   1 
ATOM 432  O O   . THR A 1 74  ? 5.80200   -10.30600 -14.59400 1.000 218.10821 ? 74  THR F O   1 
ATOM 433  C CB  . THR A 1 74  ? 6.05200   -7.77600  -12.49600 1.000 225.10632 ? 74  THR F CB  1 
ATOM 434  O OG1 . THR A 1 74  ? 5.46900   -7.07300  -11.39800 1.000 229.80248 ? 74  THR F OG1 1 
ATOM 435  C CG2 . THR A 1 74  ? 5.62100   -7.13600  -13.77600 1.000 229.59703 ? 74  THR F CG2 1 
ATOM 436  N N   . LYS A 1 75  ? 7.52800   -10.40900 -13.15300 1.000 220.66675 ? 75  LYS F N   1 
ATOM 437  C CA  . LYS A 1 75  ? 8.32000   -11.21100 -14.05400 1.000 227.23793 ? 75  LYS F CA  1 
ATOM 438  C C   . LYS A 1 75  ? 7.72800   -12.60900 -14.19700 1.000 232.85319 ? 75  LYS F C   1 
ATOM 439  O O   . LYS A 1 75  ? 7.81200   -13.19800 -15.27600 1.000 234.06305 ? 75  LYS F O   1 
ATOM 440  C CB  . LYS A 1 75  ? 9.74900   -11.31100 -13.52200 1.000 232.99299 ? 75  LYS F CB  1 
ATOM 441  C CG  . LYS A 1 75  ? 10.59000  -10.03000 -13.50600 1.000 233.21817 ? 75  LYS F CG  1 
ATOM 442  C CD  . LYS A 1 75  ? 12.09100  -10.40300 -13.40600 1.000 246.85118 ? 75  LYS F CD  1 
ATOM 443  C CE  . LYS A 1 75  ? 12.51800  -10.73500 -11.94000 1.000 249.73234 ? 75  LYS F CE  1 
ATOM 444  N NZ  . LYS A 1 75  ? 13.99700  -10.86400 -11.63600 1.000 243.26051 ? 75  LYS F NZ  1 
ATOM 445  N N   . SER A 1 76  ? 7.14400   -13.17500 -13.12400 1.000 235.82908 ? 76  SER F N   1 
ATOM 446  C CA  . SER A 1 76  ? 6.50300   -14.48800 -13.24400 1.000 238.04651 ? 76  SER F CA  1 
ATOM 447  C C   . SER A 1 76  ? 5.24400   -14.42200 -14.11800 1.000 236.05150 ? 76  SER F C   1 
ATOM 448  O O   . SER A 1 76  ? 4.98200   -15.34300 -14.89400 1.000 236.35900 ? 76  SER F O   1 
ATOM 449  C CB  . SER A 1 76  ? 6.25700   -15.11800 -11.85700 1.000 229.18491 ? 76  SER F CB  1 
ATOM 450  O OG  . SER A 1 76  ? 5.19300   -14.55000 -11.12200 1.000 228.36394 ? 76  SER F OG  1 
ATOM 451  N N   . ALA A 1 77  ? 4.44400   -13.35700 -14.01300 1.000 231.14818 ? 77  ALA F N   1 
ATOM 452  C CA  . ALA A 1 77  ? 3.27300   -13.25500 -14.88500 1.000 219.19522 ? 77  ALA F CA  1 
ATOM 453  C C   . ALA A 1 77  ? 3.70500   -13.03500 -16.32800 1.000 215.22594 ? 77  ALA F C   1 
ATOM 454  O O   . ALA A 1 77  ? 3.11000   -13.58500 -17.26000 1.000 211.31871 ? 77  ALA F O   1 
ATOM 455  C CB  . ALA A 1 77  ? 2.35400   -12.13000 -14.41700 1.000 214.47986 ? 77  ALA F CB  1 
ATOM 456  N N   . LEU A 1 78  ? 4.75900   -12.24300 -16.52400 1.000 214.86548 ? 78  LEU F N   1 
ATOM 457  C CA  . LEU A 1 78  ? 5.25200   -11.99900 -17.86500 1.000 219.67827 ? 78  LEU F CA  1 
ATOM 458  C C   . LEU A 1 78  ? 5.85000   -13.26200 -18.47100 1.000 221.33726 ? 78  LEU F C   1 
ATOM 459  O O   . LEU A 1 78  ? 5.50700   -13.63500 -19.59900 1.000 223.58679 ? 78  LEU F O   1 
ATOM 460  C CB  . LEU A 1 78  ? 6.31200   -10.89300 -17.77600 1.000 225.39779 ? 78  LEU F CB  1 
ATOM 461  C CG  . LEU A 1 78  ? 6.92800   -10.09200 -18.93400 1.000 237.29082 ? 78  LEU F CG  1 
ATOM 462  C CD1 . LEU A 1 78  ? 5.87300   -9.37000  -19.72100 1.000 236.81587 ? 78  LEU F CD1 1 
ATOM 463  C CD2 . LEU A 1 78  ? 8.01000   -9.09700  -18.47800 1.000 238.69554 ? 78  LEU F CD2 1 
ATOM 464  N N   . ARG A 1 79  ? 6.58800   -14.04000 -17.67900 1.000 222.19262 ? 79  ARG F N   1 
ATOM 465  C CA  . ARG A 1 79  ? 7.17300   -15.25500 -18.23200 1.000 225.93833 ? 79  ARG F CA  1 
ATOM 466  C C   . ARG A 1 79  ? 6.10300   -16.30800 -18.41600 1.000 226.08287 ? 79  ARG F C   1 
ATOM 467  O O   . ARG A 1 79  ? 6.20000   -17.13700 -19.32300 1.000 229.59847 ? 79  ARG F O   1 
ATOM 468  C CB  . ARG A 1 79  ? 8.27000   -15.82700 -17.34700 1.000 231.22497 ? 79  ARG F CB  1 
ATOM 469  C CG  . ARG A 1 79  ? 9.63600   -15.18900 -17.40200 1.000 227.67363 ? 79  ARG F CG  1 
ATOM 470  C CD  . ARG A 1 79  ? 10.50600  -16.02100 -16.47500 1.000 237.93383 ? 79  ARG F CD  1 
ATOM 471  N NE  . ARG A 1 79  ? 10.29500  -15.67600 -15.07600 1.000 249.78094 ? 79  ARG F NE  1 
ATOM 472  C CZ  . ARG A 1 79  ? 9.52800   -16.38600 -14.25200 1.000 253.34971 ? 79  ARG F CZ  1 
ATOM 473  N NH1 . ARG A 1 79  ? 8.90500   -17.48500 -14.65900 1.000 249.07885 ? 79  ARG F NH1 1 
ATOM 474  N NH2 . ARG A 1 79  ? 9.36300   -15.97400 -12.99500 1.000 252.68865 ? 79  ARG F NH2 1 
ATOM 475  N N   . ASP A 1 80  ? 5.09800   -16.31300 -17.53600 1.000 225.28232 ? 80  ASP F N   1 
ATOM 476  C CA  . ASP A 1 80  ? 3.94900   -17.17600 -17.73100 1.000 227.68441 ? 80  ASP F CA  1 
ATOM 477  C C   . ASP A 1 80  ? 3.22200   -16.81000 -19.02800 1.000 227.97991 ? 80  ASP F C   1 
ATOM 478  O O   . ASP A 1 80  ? 2.82500   -17.70500 -19.78100 1.000 230.51500 ? 80  ASP F O   1 
ATOM 479  C CB  . ASP A 1 80  ? 3.06300   -17.13000 -16.46500 1.000 225.39120 ? 80  ASP F CB  1 
ATOM 480  C CG  . ASP A 1 80  ? 3.74500   -17.80300 -15.21600 1.000 223.41975 ? 80  ASP F CG  1 
ATOM 481  O OD1 . ASP A 1 80  ? 4.84000   -18.40400 -15.37300 1.000 225.89482 ? 80  ASP F OD1 1 
ATOM 482  O OD2 . ASP A 1 80  ? 3.24600   -17.67200 -14.07000 1.000 216.29766 ? 80  ASP F OD2 1 
ATOM 483  N N   . LEU A 1 81  ? 3.14700   -15.52000 -19.37900 1.000 224.39219 ? 81  LEU F N   1 
ATOM 484  C CA  . LEU A 1 81  ? 2.53600   -15.19100 -20.66300 1.000 222.45795 ? 81  LEU F CA  1 
ATOM 485  C C   . LEU A 1 81  ? 3.44000   -15.52100 -21.85300 1.000 218.14307 ? 81  LEU F C   1 
ATOM 486  O O   . LEU A 1 81  ? 2.95200   -15.61000 -22.99300 1.000 202.27002 ? 81  LEU F O   1 
ATOM 487  C CB  . LEU A 1 81  ? 2.19500   -13.70800 -20.66900 1.000 222.18830 ? 81  LEU F CB  1 
ATOM 488  C CG  . LEU A 1 81  ? 0.92600   -13.24500 -21.35700 1.000 216.17039 ? 81  LEU F CG  1 
ATOM 489  C CD1 . LEU A 1 81  ? -0.25400  -14.11000 -20.96000 1.000 215.40431 ? 81  LEU F CD1 1 
ATOM 490  C CD2 . LEU A 1 81  ? 0.69600   -11.81200 -20.96100 1.000 205.03307 ? 81  LEU F CD2 1 
ATOM 491  N N   . ARG A 1 82  ? 4.72300   -15.79900 -21.58800 1.000 226.50849 ? 82  ARG F N   1 
ATOM 492  C CA  . ARG A 1 82  ? 5.71500   -16.13000 -22.61200 1.000 235.61464 ? 82  ARG F CA  1 
ATOM 493  C C   . ARG A 1 82  ? 5.77100   -17.63500 -22.78800 1.000 239.56737 ? 82  ARG F C   1 
ATOM 494  O O   . ARG A 1 82  ? 6.43500   -18.12700 -23.70600 1.000 250.36410 ? 82  ARG F O   1 
ATOM 495  C CB  . ARG A 1 82  ? 7.14500   -15.65800 -22.21600 1.000 239.51877 ? 82  ARG F CB  1 
ATOM 496  C CG  . ARG A 1 82  ? 7.37300   -14.15100 -22.08500 1.000 246.03109 ? 82  ARG F CG  1 
ATOM 497  C CD  . ARG A 1 82  ? 8.78500   -13.72600 -21.60300 1.000 246.96737 ? 82  ARG F CD  1 
ATOM 498  N NE  . ARG A 1 82  ? 8.90000   -12.26800 -21.67000 1.000 258.10449 ? 82  ARG F NE  1 
ATOM 499  C CZ  . ARG A 1 82  ? 9.95400   -11.55200 -21.29800 1.000 261.33220 ? 82  ARG F CZ  1 
ATOM 500  N NH1 . ARG A 1 82  ? 11.04100  -12.12400 -20.81000 1.000 270.08211 ? 82  ARG F NH1 1 
ATOM 501  N NH2 . ARG A 1 82  ? 9.91100   -10.22400 -21.41400 1.000 248.85314 ? 82  ARG F NH2 1 
ATOM 502  N N   . THR A 1 83  ? 5.08000   -18.35000 -21.89900 1.000 234.81725 ? 83  THR F N   1 
ATOM 503  C CA  . THR A 1 83  ? 4.78100   -19.77100 -21.96400 1.000 232.83000 ? 83  THR F CA  1 
ATOM 504  C C   . THR A 1 83  ? 3.38200   -19.97700 -22.47600 1.000 226.99071 ? 83  THR F C   1 
ATOM 505  O O   . THR A 1 83  ? 2.72500   -20.96900 -22.14300 1.000 226.02861 ? 83  THR F O   1 
ATOM 506  C CB  . THR A 1 83  ? 4.96400   -20.47500 -20.61700 1.000 231.33530 ? 83  THR F CB  1 
ATOM 507  O OG1 . THR A 1 83  ? 4.06100   -19.93500 -19.64800 1.000 230.04463 ? 83  THR F OG1 1 
ATOM 508  C CG2 . THR A 1 83  ? 6.41900   -20.35200 -20.12100 1.000 234.72251 ? 83  THR F CG2 1 
ATOM 509  N N   . VAL A 1 84  ? 2.88700   -19.03000 -23.25500 1.000 219.86842 ? 84  VAL F N   1 
ATOM 510  C CA  . VAL A 1 84  ? 1.57300   -19.20400 -23.80900 1.000 217.80903 ? 84  VAL F CA  1 
ATOM 511  C C   . VAL A 1 84  ? 1.71200   -19.21700 -25.31400 1.000 219.19158 ? 84  VAL F C   1 
ATOM 512  O O   . VAL A 1 84  ? 2.29800   -18.28900 -25.90200 1.000 201.92788 ? 84  VAL F O   1 
ATOM 513  C CB  . VAL A 1 84  ? 0.68500   -18.02400 -23.39000 1.000 209.61442 ? 84  VAL F CB  1 
ATOM 514  C CG1 . VAL A 1 84  ? -0.70600  -18.23200 -23.86300 1.000 220.44241 ? 84  VAL F CG1 1 
ATOM 515  C CG2 . VAL A 1 84  ? 0.72800   -17.85000 -21.92200 1.000 215.76692 ? 84  VAL F CG2 1 
ATOM 516  N N   . SER A 1 85  ? 1.12800   -20.26800 -25.92500 1.000 231.85574 ? 85  SER F N   1 
ATOM 517  C CA  . SER A 1 85  ? 1.10800   -20.45500 -27.36900 1.000 234.30916 ? 85  SER F CA  1 
ATOM 518  C C   . SER A 1 85  ? -0.07200  -21.28200 -27.87900 1.000 228.46531 ? 85  SER F C   1 
ATOM 519  O O   . SER A 1 85  ? -0.38600  -22.34100 -27.32000 1.000 217.82614 ? 85  SER F O   1 
ATOM 520  C CB  . SER A 1 85  ? 2.38000   -21.18400 -27.86300 1.000 237.44939 ? 85  SER F CB  1 
ATOM 521  O OG  . SER A 1 85  ? 2.48700   -22.49500 -27.30400 1.000 233.24887 ? 85  SER F OG  1 
ATOM 522  N N   . ALA A 1 86  ? -0.69400  -20.78200 -28.95800 1.000 232.40059 ? 86  ALA F N   1 
ATOM 523  C CA  . ALA A 1 86  ? -1.78900  -21.37700 -29.71000 1.000 227.60967 ? 86  ALA F CA  1 
ATOM 524  C C   . ALA A 1 86  ? -0.98600  -21.95900 -30.88700 1.000 243.00691 ? 86  ALA F C   1 
ATOM 525  O O   . ALA A 1 86  ? 0.24600   -21.88600 -30.85800 1.000 249.38095 ? 86  ALA F O   1 
ATOM 526  C CB  . ALA A 1 86  ? -2.89600  -20.37900 -30.08100 1.000 211.72356 ? 86  ALA F CB  1 
ATOM 527  N N   . ASP A 1 87  ? -1.60700  -22.49300 -31.94300 1.000 246.53823 ? 87  ASP F N   1 
ATOM 528  C CA  . ASP A 1 87  ? -0.72500  -22.93500 -33.07700 1.000 246.68944 ? 87  ASP F CA  1 
ATOM 529  C C   . ASP A 1 87  ? -1.02700  -22.30600 -34.46200 1.000 230.91955 ? 87  ASP F C   1 
ATOM 530  O O   . ASP A 1 87  ? -1.89400  -22.75600 -35.21700 1.000 226.79230 ? 87  ASP F O   1 
ATOM 531  C CB  . ASP A 1 87  ? -0.65900  -24.49400 -33.20200 1.000 249.83582 ? 87  ASP F CB  1 
ATOM 532  C CG  . ASP A 1 87  ? 0.09500   -25.18700 -32.00400 1.000 255.49994 ? 87  ASP F CG  1 
ATOM 533  O OD1 . ASP A 1 87  ? 0.66200   -24.48300 -31.13600 1.000 261.32866 ? 87  ASP F OD1 1 
ATOM 534  O OD2 . ASP A 1 87  ? 0.21800   -26.43600 -31.96500 1.000 249.50506 ? 87  ASP F OD2 1 
ATOM 535  N N   . LEU A 1 106 ? -19.78700 -22.90300 -34.60000 1.000 265.69900 ? 106 LEU F N   1 
ATOM 536  C CA  . LEU A 1 106 ? -20.40400 -22.27200 -33.42200 1.000 281.38680 ? 106 LEU F CA  1 
ATOM 537  C C   . LEU A 1 106 ? -21.41200 -21.13700 -33.87100 1.000 283.02764 ? 106 LEU F C   1 
ATOM 538  O O   . LEU A 1 106 ? -21.10700 -19.94300 -33.79500 1.000 285.61416 ? 106 LEU F O   1 
ATOM 539  C CB  . LEU A 1 106 ? -19.28900 -21.75200 -32.42700 1.000 275.11351 ? 106 LEU F CB  1 
ATOM 540  C CG  . LEU A 1 106 ? -18.14200 -22.54900 -31.69800 1.000 253.90912 ? 106 LEU F CG  1 
ATOM 541  C CD1 . LEU A 1 106 ? -17.07900 -21.70900 -30.94500 1.000 228.23030 ? 106 LEU F CD1 1 
ATOM 542  C CD2 . LEU A 1 106 ? -18.72500 -23.48700 -30.68200 1.000 253.19176 ? 106 LEU F CD2 1 
ATOM 543  N N   . GLY A 1 107 ? -22.61700 -21.51800 -34.33100 1.000 276.17505 ? 107 GLY F N   1 
ATOM 544  C CA  . GLY A 1 107 ? -23.66500 -20.58300 -34.73400 1.000 258.66458 ? 107 GLY F CA  1 
ATOM 545  C C   . GLY A 1 107 ? -23.44700 -19.93500 -36.08800 1.000 258.18674 ? 107 GLY F C   1 
ATOM 546  O O   . GLY A 1 107 ? -24.29300 -19.13300 -36.50900 1.000 242.95098 ? 107 GLY F O   1 
ATOM 547  N N   . VAL A 1 108 ? -22.36200 -20.32900 -36.78800 1.000 270.67132 ? 108 VAL F N   1 
ATOM 548  C CA  . VAL A 1 108 ? -21.77400 -19.93200 -38.08700 1.000 270.80891 ? 108 VAL F CA  1 
ATOM 549  C C   . VAL A 1 108 ? -21.04000 -18.56800 -38.20900 1.000 268.05478 ? 108 VAL F C   1 
ATOM 550  O O   . VAL A 1 108 ? -19.88800 -18.53500 -38.67600 1.000 259.62588 ? 108 VAL F O   1 
ATOM 551  C CB  . VAL A 1 108 ? -22.84600 -20.06400 -39.19500 1.000 264.39612 ? 108 VAL F CB  1 
ATOM 552  C CG1 . VAL A 1 108 ? -22.37100 -19.42300 -40.50800 1.000 251.19128 ? 108 VAL F CG1 1 
ATOM 553  C CG2 . VAL A 1 108 ? -23.23200 -21.54300 -39.39500 1.000 254.26227 ? 108 VAL F CG2 1 
ATOM 554  N N   . ALA A 1 109 ? -21.66300 -17.44200 -37.79500 1.000 267.47523 ? 109 ALA F N   1 
ATOM 555  C CA  . ALA A 1 109 ? -21.04000 -16.11200 -37.97200 1.000 253.70336 ? 109 ALA F CA  1 
ATOM 556  C C   . ALA A 1 109 ? -19.71900 -15.97900 -37.23100 1.000 245.85979 ? 109 ALA F C   1 
ATOM 557  O O   . ALA A 1 109 ? -18.74500 -15.38600 -37.73300 1.000 238.31504 ? 109 ALA F O   1 
ATOM 558  C CB  . ALA A 1 109 ? -21.99000 -15.01900 -37.48100 1.000 240.11236 ? 109 ALA F CB  1 
ATOM 559  N N   . THR A 1 110 ? -19.71400 -16.45100 -35.99700 1.000 246.47067 ? 110 THR F N   1 
ATOM 560  C CA  . THR A 1 110 ? -18.53400 -16.41900 -35.16800 1.000 237.30666 ? 110 THR F CA  1 
ATOM 561  C C   . THR A 1 110 ? -17.39200 -17.23900 -35.78400 1.000 234.71800 ? 110 THR F C   1 
ATOM 562  O O   . THR A 1 110 ? -16.24400 -16.79800 -35.74900 1.000 233.56125 ? 110 THR F O   1 
ATOM 563  C CB  . THR A 1 110 ? -18.91200 -16.81500 -33.74000 1.000 243.87420 ? 110 THR F CB  1 
ATOM 564  O OG1 . THR A 1 110 ? -18.96900 -18.23000 -33.62100 1.000 255.32502 ? 110 THR F OG1 1 
ATOM 565  C CG2 . THR A 1 110 ? -20.29600 -16.20800 -33.36800 1.000 242.08760 ? 110 THR F CG2 1 
ATOM 566  N N   . ALA A 1 111 ? -17.66800 -18.43400 -36.34700 1.000 232.85342 ? 111 ALA F N   1 
ATOM 567  C CA  . ALA A 1 111 ? -16.56100 -19.20600 -36.93000 1.000 221.93135 ? 111 ALA F CA  1 
ATOM 568  C C   . ALA A 1 111 ? -15.93700 -18.53500 -38.15100 1.000 220.81583 ? 111 ALA F C   1 
ATOM 569  O O   . ALA A 1 111 ? -14.70200 -18.52700 -38.30400 1.000 218.78912 ? 111 ALA F O   1 
ATOM 570  C CB  . ALA A 1 111 ? -17.07900 -20.58900 -37.31800 1.000 226.46547 ? 111 ALA F CB  1 
ATOM 571  N N   . ALA A 1 112 ? -16.73900 -17.92100 -39.00500 1.000 224.41530 ? 112 ALA F N   1 
ATOM 572  C CA  . ALA A 1 112 ? -16.13400 -17.21700 -40.12500 1.000 231.17138 ? 112 ALA F CA  1 
ATOM 573  C C   . ALA A 1 112 ? -15.32600 -16.03100 -39.59300 1.000 240.26478 ? 112 ALA F C   1 
ATOM 574  O O   . ALA A 1 112 ? -14.21000 -15.74000 -40.06500 1.000 247.69071 ? 112 ALA F O   1 
ATOM 575  C CB  . ALA A 1 112 ? -17.21000 -16.78800 -41.11100 1.000 234.59510 ? 112 ALA F CB  1 
ATOM 576  N N   . ALA A 1 113 ? -15.86700 -15.38600 -38.54400 1.000 237.45624 ? 113 ALA F N   1 
ATOM 577  C CA  . ALA A 1 113 ? -15.22700 -14.23700 -37.89400 1.000 231.99118 ? 113 ALA F CA  1 
ATOM 578  C C   . ALA A 1 113 ? -13.87300 -14.61600 -37.27100 1.000 229.19974 ? 113 ALA F C   1 
ATOM 579  O O   . ALA A 1 113 ? -12.90900 -13.83300 -37.29800 1.000 229.36123 ? 113 ALA F O   1 
ATOM 580  C CB  . ALA A 1 113 ? -16.18200 -13.63900 -36.86500 1.000 227.57958 ? 113 ALA F CB  1 
ATOM 581  N N   . VAL A 1 114 ? -13.78500 -15.80200 -36.67700 1.000 225.08613 ? 114 VAL F N   1 
ATOM 582  C CA  . VAL A 1 114 ? -12.53100 -16.23200 -36.06400 1.000 216.60655 ? 114 VAL F CA  1 
ATOM 583  C C   . VAL A 1 114 ? -11.51800 -16.48300 -37.14900 1.000 214.62096 ? 114 VAL F C   1 
ATOM 584  O O   . VAL A 1 114 ? -10.31400 -16.27400 -36.95700 1.000 208.48517 ? 114 VAL F O   1 
ATOM 585  C CB  . VAL A 1 114 ? -12.70800 -17.47100 -35.18900 1.000 220.24309 ? 114 VAL F CB  1 
ATOM 586  C CG1 . VAL A 1 114 ? -11.36400 -17.86600 -34.60500 1.000 227.38588 ? 114 VAL F CG1 1 
ATOM 587  C CG2 . VAL A 1 114 ? -13.66600 -17.14000 -34.07500 1.000 229.09659 ? 114 VAL F CG2 1 
ATOM 588  N N   . THR A 1 115 ? -11.96300 -17.03700 -38.27100 1.000 217.94800 ? 115 THR F N   1 
ATOM 589  C CA  . THR A 1 115 ? -10.98400 -17.19100 -39.32700 1.000 219.75966 ? 115 THR F CA  1 
ATOM 590  C C   . THR A 1 115 ? -10.40000 -15.80900 -39.68500 1.000 224.54407 ? 115 THR F C   1 
ATOM 591  O O   . THR A 1 115 ? -9.16900  -15.67000 -39.80900 1.000 222.77828 ? 115 THR F O   1 
ATOM 592  C CB  . THR A 1 115 ? -11.60100 -17.93900 -40.53700 1.000 219.07223 ? 115 THR F CB  1 
ATOM 593  O OG1 . THR A 1 115 ? -12.53400 -17.13600 -41.28400 1.000 219.87484 ? 115 THR F OG1 1 
ATOM 594  C CG2 . THR A 1 115 ? -12.28900 -19.22200 -40.07700 1.000 217.99572 ? 115 THR F CG2 1 
ATOM 595  N N   . CYS A 1 116 ? -11.23600 -14.74600 -39.71800 1.000 230.99120 ? 116 CYS F N   1 
ATOM 596  C CA  . CYS A 1 116 ? -10.66100 -13.38100 -39.80400 1.000 230.26718 ? 116 CYS F CA  1 
ATOM 597  C C   . CYS A 1 116 ? -9.58900  -13.13500 -38.74400 1.000 224.61044 ? 116 CYS F C   1 
ATOM 598  O O   . CYS A 1 116 ? -8.45200  -12.75300 -39.05100 1.000 223.74472 ? 116 CYS F O   1 
ATOM 599  C CB  . CYS A 1 116 ? -11.69900 -12.24500 -39.66700 1.000 232.07697 ? 116 CYS F CB  1 
ATOM 600  S SG  . CYS A 1 116 ? -13.22700 -12.08900 -40.66600 1.000 247.22994 ? 116 CYS F SG  1 
ATOM 601  N N   . GLY A 1 117 ? -9.97100  -13.25500 -37.48700 1.000 223.68387 ? 117 GLY F N   1 
ATOM 602  C CA  . GLY A 1 117 ? -9.04700  -12.92300 -36.42000 1.000 220.54636 ? 117 GLY F CA  1 
ATOM 603  C C   . GLY A 1 117 ? -7.70600  -13.61100 -36.56400 1.000 216.68708 ? 117 GLY F C   1 
ATOM 604  O O   . GLY A 1 117 ? -6.64800  -12.98200 -36.39500 1.000 212.97910 ? 117 GLY F O   1 
ATOM 605  N N   . VAL A 1 118 ? -7.72900  -14.88800 -36.96600 1.000 220.97158 ? 118 VAL F N   1 
ATOM 606  C CA  . VAL A 1 118 ? -6.47200  -15.62000 -37.11500 1.000 225.54284 ? 118 VAL F CA  1 
ATOM 607  C C   . VAL A 1 118 ? -5.68400  -15.02600 -38.23100 1.000 224.00592 ? 118 VAL F C   1 
ATOM 608  O O   . VAL A 1 118 ? -4.45700  -14.88700 -38.15500 1.000 226.28847 ? 118 VAL F O   1 
ATOM 609  C CB  . VAL A 1 118 ? -6.72800  -17.10000 -37.45800 1.000 229.41384 ? 118 VAL F CB  1 
ATOM 610  C CG1 . VAL A 1 118 ? -5.41200  -17.84700 -37.46400 1.000 234.61596 ? 118 VAL F CG1 1 
ATOM 611  C CG2 . VAL A 1 118 ? -7.68700  -17.71300 -36.45700 1.000 223.94524 ? 118 VAL F CG2 1 
ATOM 612  N N   . ALA A 1 119 ? -6.38800  -14.54800 -39.22800 1.000 223.24400 ? 119 ALA F N   1 
ATOM 613  C CA  . ALA A 1 119 ? -5.68600  -14.00000 -40.35800 1.000 229.42341 ? 119 ALA F CA  1 
ATOM 614  C C   . ALA A 1 119 ? -4.92100  -12.77700 -39.88000 1.000 233.15785 ? 119 ALA F C   1 
ATOM 615  O O   . ALA A 1 119 ? -3.75300  -12.56600 -40.24400 1.000 238.18143 ? 119 ALA F O   1 
ATOM 616  C CB  . ALA A 1 119 ? -6.65000  -13.69000 -41.51200 1.000 227.19591 ? 119 ALA F CB  1 
ATOM 617  N N   . ILE A 1 120 ? -5.53500  -12.00300 -38.98400 1.000 226.09572 ? 120 ILE F N   1 
ATOM 618  C CA  . ILE A 1 120 ? -4.81900  -10.80400 -38.55400 1.000 230.10041 ? 120 ILE F CA  1 
ATOM 619  C C   . ILE A 1 120 ? -3.68600  -11.05300 -37.55700 1.000 232.37961 ? 120 ILE F C   1 
ATOM 620  O O   . ILE A 1 120 ? -2.61800  -10.41100 -37.66100 1.000 238.19253 ? 120 ILE F O   1 
ATOM 621  C CB  . ILE A 1 120 ? -5.83900  -9.88100  -37.85600 1.000 233.57431 ? 120 ILE F CB  1 
ATOM 622  C CG1 . ILE A 1 120 ? -7.06800  -9.58600  -38.73300 1.000 233.95064 ? 120 ILE F CG1 1 
ATOM 623  C CG2 . ILE A 1 120 ? -5.21400  -8.56400  -37.49900 1.000 247.17546 ? 120 ILE F CG2 1 
ATOM 624  C CD1 . ILE A 1 120 ? -8.38500  -9.59700  -37.94500 1.000 216.83340 ? 120 ILE F CD1 1 
ATOM 625  N N   . ALA A 1 121 ? -3.80200  -12.02300 -36.65500 1.000 230.46640 ? 121 ALA F N   1 
ATOM 626  C CA  . ALA A 1 121 ? -2.59900  -12.26600 -35.86000 1.000 244.19304 ? 121 ALA F CA  1 
ATOM 627  C C   . ALA A 1 121 ? -1.43900  -12.78400 -36.70000 1.000 256.92256 ? 121 ALA F C   1 
ATOM 628  O O   . ALA A 1 121 ? -0.27900  -12.35600 -36.49400 1.000 263.71059 ? 121 ALA F O   1 
ATOM 629  C CB  . ALA A 1 121 ? -2.88500  -13.24500 -34.73100 1.000 240.01733 ? 121 ALA F CB  1 
ATOM 630  N N   . LYS A 1 122 ? -1.75800  -13.54400 -37.75800 1.000 256.68369 ? 122 LYS F N   1 
ATOM 631  C CA  . LYS A 1 122 ? -0.71100  -14.03400 -38.64700 1.000 268.81454 ? 122 LYS F CA  1 
ATOM 632  C C   . LYS A 1 122 ? -0.00400  -12.89100 -39.34200 1.000 277.46515 ? 122 LYS F C   1 
ATOM 633  O O   . LYS A 1 122 ? 1.20900   -12.66600 -39.16300 1.000 289.90886 ? 122 LYS F O   1 
ATOM 634  C CB  . LYS A 1 122 ? -1.28600  -15.03400 -39.64600 1.000 263.70889 ? 122 LYS F CB  1 
ATOM 635  C CG  . LYS A 1 122 ? -1.91200  -16.23800 -38.94800 1.000 255.88944 ? 122 LYS F CG  1 
ATOM 636  C CD  . LYS A 1 122 ? -2.49900  -17.22900 -39.90900 1.000 247.00036 ? 122 LYS F CD  1 
ATOM 637  C CE  . LYS A 1 122 ? -3.38300  -16.52500 -40.91500 1.000 245.75694 ? 122 LYS F CE  1 
ATOM 638  N NZ  . LYS A 1 122 ? -4.75600  -17.08800 -40.90300 1.000 238.50704 ? 122 LYS F NZ  1 
ATOM 639  N N   . CYS A 1 123 ? -0.75400  -12.14000 -40.15000 1.000 271.41853 ? 123 CYS F N   1 
ATOM 640  C CA  . CYS A 1 123 ? -0.10800  -11.06400 -40.95000 1.000 282.22972 ? 123 CYS F CA  1 
ATOM 641  C C   . CYS A 1 123 ? 0.59700   -10.05700 -40.03300 1.000 284.86231 ? 123 CYS F C   1 
ATOM 642  O O   . CYS A 1 123 ? 1.22700   -9.12300  -40.56600 1.000 289.21148 ? 123 CYS F O   1 
ATOM 643  C CB  . CYS A 1 123 ? -1.11700  -10.33800 -41.83200 1.000 283.47083 ? 123 CYS F CB  1 
ATOM 644  S SG  . CYS A 1 123 ? -0.33500  -9.18900  -42.99600 1.000 297.81032 ? 123 CYS F SG  1 
ATOM 645  N N   . ILE A 1 124 ? 0.49800   -10.23200 -38.71400 1.000 277.81303 ? 124 ILE F N   1 
ATOM 646  C CA  . ILE A 1 124 ? 1.09700   -9.22000  -37.79300 1.000 278.04464 ? 124 ILE F CA  1 
ATOM 647  C C   . ILE A 1 124 ? 2.59400   -9.50900  -37.64300 1.000 290.68636 ? 124 ILE F C   1 
ATOM 648  O O   . ILE A 1 124 ? 3.40300   -8.64400  -38.02000 1.000 295.66870 ? 124 ILE F O   1 
ATOM 649  C CB  . ILE A 1 124 ? 0.36800   -9.18900  -36.43600 1.000 271.15353 ? 124 ILE F CB  1 
ATOM 650  C CG1 . ILE A 1 124 ? -0.84800  -8.26100  -36.47900 1.000 264.98342 ? 124 ILE F CG1 1 
ATOM 651  C CG2 . ILE A 1 124 ? 1.32000   -8.79700  -35.31800 1.000 275.59422 ? 124 ILE F CG2 1 
ATOM 652  C CD1 . ILE A 1 124 ? -1.66200  -8.25300  -35.20800 1.000 255.13952 ? 124 ILE F CD1 1 
ATOM 653  N N   . ARG A 1 125 ? 2.93700   -10.69800 -37.14600 1.000 286.32232 ? 125 ARG F N   1 
ATOM 654  C CA  . ARG A 1 125 ? 4.36400   -11.08000 -37.00200 1.000 281.54898 ? 125 ARG F CA  1 
ATOM 655  C C   . ARG A 1 125 ? 4.99900   -11.07600 -38.39400 1.000 299.44641 ? 125 ARG F C   1 
ATOM 656  O O   . ARG A 1 125 ? 6.23900   -10.99700 -38.48200 1.000 294.88892 ? 125 ARG F O   1 
ATOM 657  C CB  . ARG A 1 125 ? 4.47300   -12.45400 -36.33700 1.000 270.12658 ? 125 ARG F CB  1 
ATOM 658  C CG  . ARG A 1 125 ? 3.47700   -12.66100 -35.20400 1.000 258.81404 ? 125 ARG F CG  1 
ATOM 659  C CD  . ARG A 1 125 ? 2.61600   -13.88500 -35.44300 1.000 267.55165 ? 125 ARG F CD  1 
ATOM 660  N NE  . ARG A 1 125 ? 2.23400   -14.00200 -36.84300 1.000 282.02845 ? 125 ARG F NE  1 
ATOM 661  C CZ  . ARG A 1 125 ? 2.54500   -15.03300 -37.61900 1.000 292.90594 ? 125 ARG F CZ  1 
ATOM 662  N NH1 . ARG A 1 125 ? 2.79900   -16.21300 -37.08000 1.000 308.07341 ? 125 ARG F NH1 1 
ATOM 663  N NH2 . ARG A 1 125 ? 2.61700   -14.87800 -38.92800 1.000 293.89954 ? 125 ARG F NH2 1 
ATOM 664  N N   . LEU A 1 126 ? 4.16500   -11.14700 -39.43400 1.000 313.65839 ? 126 LEU F N   1 
ATOM 665  C CA  . LEU A 1 126 ? 4.67900   -11.11900 -40.82800 1.000 318.78157 ? 126 LEU F CA  1 
ATOM 666  C C   . LEU A 1 126 ? 5.50000   -9.84400  -41.03400 1.000 326.66316 ? 126 LEU F C   1 
ATOM 667  O O   . LEU A 1 126 ? 5.23100   -8.84800  -40.33300 1.000 327.17483 ? 126 LEU F O   1 
ATOM 668  C CB  . LEU A 1 126 ? 3.49900   -11.17700 -41.80200 1.000 309.89854 ? 126 LEU F CB  1 
ATOM 669  C CG  . LEU A 1 126 ? 2.88500   -12.56100 -41.99800 1.000 295.98950 ? 126 LEU F CG  1 
ATOM 670  C CD1 . LEU A 1 126 ? 2.11900   -12.63300 -43.30900 1.000 289.22039 ? 126 LEU F CD1 1 
ATOM 671  C CD2 . LEU A 1 126 ? 3.95600   -13.64000 -41.94500 1.000 300.34993 ? 126 LEU F CD2 1 
ATOM 672  N N   . GLU A 1 127 ? 6.56600   -10.02500 -41.95200 1.000 332.55391 ? 127 GLU F N   1 
ATOM 673  C CA  . GLU A 1 127 ? 7.50600   -8.90900  -42.25700 1.000 331.15888 ? 127 GLU F CA  1 
ATOM 674  C C   . GLU A 1 127 ? 7.78700   -8.11200  -40.97700 1.000 322.93243 ? 127 GLU F C   1 
ATOM 675  O O   . GLU A 1 127 ? 7.92200   -6.87400  -41.06600 1.000 326.03042 ? 127 GLU F O   1 
ATOM 676  C CB  . GLU A 1 127 ? 6.95700   -8.01300  -43.37400 1.000 325.79063 ? 127 GLU F CB  1 
ATOM 677  C CG  . GLU A 1 127 ? 5.68600   -7.25700  -43.01900 1.000 320.23479 ? 127 GLU F CG  1 
ATOM 678  C CD  . GLU A 1 127 ? 4.38700   -7.97500  -43.34300 1.000 307.23643 ? 127 GLU F CD  1 
ATOM 679  O OE1 . GLU A 1 127 ? 4.44500   -9.02500  -44.01200 1.000 308.27960 ? 127 GLU F OE1 1 
ATOM 680  O OE2 . GLU A 1 127 ? 3.32500   -7.49900  -42.89800 1.000 293.70265 ? 127 GLU F OE2 1 
ATOM 681  N N   . SER A 1 128 ? 7.77400   -8.73200  -39.85500 1.000 309.14257 ? 128 SER F N   1 
ATOM 682  C CA  . SER A 1 128 ? 8.00000   -8.08400  -38.54100 1.000 280.96362 ? 128 SER F CA  1 
ATOM 683  C C   . SER A 1 128 ? 7.24500   -6.75600  -38.54700 1.000 289.05510 ? 128 SER F C   1 
ATOM 684  O O   . SER A 1 128 ? 7.83400   -5.73500  -38.15400 1.000 285.73533 ? 128 SER F O   1 
ATOM 685  C CB  . SER A 1 128 ? 9.46500   -7.88600  -38.27600 1.000 274.13835 ? 128 SER F CB  1 
ATOM 686  O OG  . SER A 1 128 ? 10.01200  -6.92500  -39.16700 1.000 278.80077 ? 128 SER F OG  1 
ATOM 687  N N   . GLU A 1 129 ? 6.05100   -6.70700  -39.03100 1.000 299.89657 ? 129 GLU F N   1 
ATOM 688  C CA  . GLU A 1 129 ? 5.29600   -5.43200  -39.08100 1.000 295.53707 ? 129 GLU F CA  1 
ATOM 689  C C   . GLU A 1 129 ? 5.43300   -4.74300  -37.72000 1.000 276.47081 ? 129 GLU F C   1 
ATOM 690  O O   . GLU A 1 129 ? 5.36800   -3.50700  -37.68200 1.000 271.42099 ? 129 GLU F O   1 
ATOM 691  C CB  . GLU A 1 129 ? 3.83600   -5.69400  -39.44800 1.000 293.86394 ? 129 GLU F CB  1 
ATOM 692  C CG  . GLU A 1 129 ? 3.09700   -4.44500  -39.88700 1.000 286.41913 ? 129 GLU F CG  1 
ATOM 693  C CD  . GLU A 1 129 ? 3.43100   -3.93800  -41.28000 1.000 291.46171 ? 129 GLU F CD  1 
ATOM 694  O OE1 . GLU A 1 129 ? 4.25100   -4.57900  -41.96400 1.000 301.63696 ? 129 GLU F OE1 1 
ATOM 695  O OE2 . GLU A 1 129 ? 2.86700   -2.90000  -41.67700 1.000 286.73991 ? 129 GLU F OE2 1 
ATOM 696  N N   . VAL A 1 130 ? 5.63100   -5.61900  -36.67100 1.000 265.40290 ? 130 VAL F N   1 
ATOM 697  C CA  . VAL A 1 130 ? 5.97600   -5.08000  -35.32800 1.000 268.78826 ? 130 VAL F CA  1 
ATOM 698  C C   . VAL A 1 130 ? 7.00200   -3.96500  -35.53700 1.000 278.08320 ? 130 VAL F C   1 
ATOM 699  O O   . VAL A 1 130 ? 6.68300   -2.80400  -35.24400 1.000 273.48862 ? 130 VAL F O   1 
ATOM 700  C CB  . VAL A 1 130 ? 6.50300   -6.18200  -34.38900 1.000 277.57863 ? 130 VAL F CB  1 
ATOM 701  C CG1 . VAL A 1 130 ? 5.36500   -6.93300  -33.71700 1.000 277.53950 ? 130 VAL F CG1 1 
ATOM 702  C CG2 . VAL A 1 130 ? 7.43700   -7.15200  -35.09500 1.000 271.44420 ? 130 VAL F CG2 1 
ATOM 703  N N   . THR A 1 131 ? 8.13700   -4.27400  -36.06300 1.000 288.89866 ? 131 THR F N   1 
ATOM 704  C CA  . THR A 1 131 ? 9.24600   -3.30800  -36.25800 1.000 295.12989 ? 131 THR F CA  1 
ATOM 705  C C   . THR A 1 131 ? 8.68300   -2.06100  -36.94000 1.000 291.04557 ? 131 THR F C   1 
ATOM 706  O O   . THR A 1 131 ? 8.94600   -0.94800  -36.44800 1.000 292.32146 ? 131 THR F O   1 
ATOM 707  C CB  . THR A 1 131 ? 10.37900  -3.92600  -37.08400 1.000 298.59106 ? 131 THR F CB  1 
ATOM 708  O OG1 . THR A 1 131 ? 9.85400   -4.26400  -38.36800 1.000 298.87127 ? 131 THR F OG1 1 
ATOM 709  C CG2 . THR A 1 131 ? 10.97700  -5.15400  -36.43200 1.000 299.31983 ? 131 THR F CG2 1 
ATOM 710  N N   . ALA A 1 132 ? 7.92800   -2.25400  -38.02200 1.000 291.02684 ? 132 ALA F N   1 
ATOM 711  C CA  . ALA A 1 132 ? 7.30000   -1.10900  -38.71400 1.000 282.59756 ? 132 ALA F CA  1 
ATOM 712  C C   . ALA A 1 132 ? 6.38600   -0.37500  -37.72900 1.000 273.85261 ? 132 ALA F C   1 
ATOM 713  O O   . ALA A 1 132 ? 6.69200   0.78000   -37.38200 1.000 276.92221 ? 132 ALA F O   1 
ATOM 714  C CB  . ALA A 1 132 ? 6.53700   -1.59800  -39.91800 1.000 282.32404 ? 132 ALA F CB  1 
ATOM 715  N N   . ILE A 1 133 ? 5.32200   -0.95300  -37.28700 1.000 263.52111 ? 133 ILE F N   1 
ATOM 716  C CA  . ILE A 1 133 ? 4.34100   -0.24100  -36.42000 1.000 253.56525 ? 133 ILE F CA  1 
ATOM 717  C C   . ILE A 1 133 ? 5.07400   0.29100   -35.18400 1.000 259.15432 ? 133 ILE F C   1 
ATOM 718  O O   . ILE A 1 133 ? 4.64800   1.32600   -34.64400 1.000 258.76412 ? 133 ILE F O   1 
ATOM 719  C CB  . ILE A 1 133 ? 3.16100   -1.16600  -36.05900 1.000 237.57294 ? 133 ILE F CB  1 
ATOM 720  C CG1 . ILE A 1 133 ? 3.58700   -2.35300  -35.19000 1.000 241.65865 ? 133 ILE F CG1 1 
ATOM 721  C CG2 . ILE A 1 133 ? 2.44500   -1.62700  -37.31900 1.000 246.58110 ? 133 ILE F CG2 1 
ATOM 722  C CD1 . ILE A 1 133 ? 3.43400   -2.12300  -33.70300 1.000 242.04073 ? 133 ILE F CD1 1 
ATOM 723  N N   . LYS A 1 134 ? 6.13200   -0.45800  -34.73600 1.000 264.95986 ? 134 LYS F N   1 
ATOM 724  C CA  . LYS A 1 134 ? 6.94300   0.05400   -33.60400 1.000 268.72774 ? 134 LYS F CA  1 
ATOM 725  C C   . LYS A 1 134 ? 7.48600   1.42700   -34.00000 1.000 267.79691 ? 134 LYS F C   1 
ATOM 726  O O   . LYS A 1 134 ? 7.19000   2.40700   -33.28900 1.000 258.78243 ? 134 LYS F O   1 
ATOM 727  C CB  . LYS A 1 134 ? 8.08300   -0.91100  -33.27000 1.000 275.43290 ? 134 LYS F CB  1 
ATOM 728  C CG  . LYS A 1 134 ? 7.73000   -2.00300  -32.26900 1.000 274.63848 ? 134 LYS F CG  1 
ATOM 729  C CD  . LYS A 1 134 ? 8.62200   -3.21900  -32.37200 1.000 275.34455 ? 134 LYS F CD  1 
ATOM 730  C CE  . LYS A 1 134 ? 10.04500  -2.87900  -32.76000 1.000 263.48239 ? 134 LYS F CE  1 
ATOM 731  N NZ  . LYS A 1 134 ? 10.79800  -4.08100  -33.18600 1.000 272.97785 ? 134 LYS F NZ  1 
ATOM 732  N N   . ASN A 1 135 ? 8.23300   1.48700   -35.10500 1.000 275.19365 ? 135 ASN F N   1 
ATOM 733  C CA  . ASN A 1 135 ? 8.72000   2.78500   -35.55800 1.000 272.63632 ? 135 ASN F CA  1 
ATOM 734  C C   . ASN A 1 135 ? 7.57700   3.79700   -35.58700 1.000 263.52625 ? 135 ASN F C   1 
ATOM 735  O O   . ASN A 1 135 ? 7.71500   4.90700   -35.06900 1.000 258.81823 ? 135 ASN F O   1 
ATOM 736  C CB  . ASN A 1 135 ? 9.40500   2.67500   -36.93500 1.000 279.45271 ? 135 ASN F CB  1 
ATOM 737  C CG  . ASN A 1 135 ? 10.74900  1.90200   -36.90300 1.000 283.21296 ? 135 ASN F CG  1 
ATOM 738  O OD1 . ASN A 1 135 ? 11.46100  1.90600   -35.89100 1.000 289.09153 ? 135 ASN F OD1 1 
ATOM 739  N ND2 . ASN A 1 135 ? 11.10300  1.26600   -38.02800 1.000 275.41358 ? 135 ASN F ND2 1 
ATOM 740  N N   . ALA A 1 136 ? 6.40200   3.37300   -36.12600 1.000 263.38869 ? 136 ALA F N   1 
ATOM 741  C CA  . ALA A 1 136 ? 5.20400   4.22100   -36.22000 1.000 255.83554 ? 136 ALA F CA  1 
ATOM 742  C C   . ALA A 1 136 ? 4.56100   4.63000   -34.90100 1.000 251.62517 ? 136 ALA F C   1 
ATOM 743  O O   . ALA A 1 136 ? 3.82800   5.63200   -34.88600 1.000 243.57493 ? 136 ALA F O   1 
ATOM 744  C CB  . ALA A 1 136 ? 4.14500   3.51200   -37.06000 1.000 255.05931 ? 136 ALA F CB  1 
ATOM 745  N N   . LEU A 1 137 ? 4.71400   3.86600   -33.81000 1.000 258.66617 ? 137 LEU F N   1 
ATOM 746  C CA  . LEU A 1 137 ? 4.03000   4.34100   -32.61700 1.000 260.77964 ? 137 LEU F CA  1 
ATOM 747  C C   . LEU A 1 137 ? 4.98000   4.97500   -31.60700 1.000 264.63482 ? 137 LEU F C   1 
ATOM 748  O O   . LEU A 1 137 ? 4.57300   5.19400   -30.45900 1.000 266.30815 ? 137 LEU F O   1 
ATOM 749  C CB  . LEU A 1 137 ? 3.16600   3.25600   -31.96100 1.000 256.76194 ? 137 LEU F CB  1 
ATOM 750  C CG  . LEU A 1 137 ? 1.92700   2.73200   -32.70000 1.000 243.28294 ? 137 LEU F CG  1 
ATOM 751  C CD1 . LEU A 1 137 ? 1.30500   1.61400   -31.86500 1.000 228.93922 ? 137 LEU F CD1 1 
ATOM 752  C CD2 . LEU A 1 137 ? 0.91700   3.86800   -32.94700 1.000 236.75940 ? 137 LEU F CD2 1 
ATOM 753  N N   . LYS A 1 138 ? 6.27200   5.12100   -31.93700 1.000 265.00677 ? 138 LYS F N   1 
ATOM 754  C CA  . LYS A 1 138 ? 7.15800   5.82300   -31.01200 1.000 268.21931 ? 138 LYS F CA  1 
ATOM 755  C C   . LYS A 1 138 ? 6.69700   7.27500   -31.01400 1.000 276.11274 ? 138 LYS F C   1 
ATOM 756  O O   . LYS A 1 138 ? 6.60100   7.94200   -29.97400 1.000 282.14890 ? 138 LYS F O   1 
ATOM 757  C CB  . LYS A 1 138 ? 8.65700   5.64600   -31.32100 1.000 257.83733 ? 138 LYS F CB  1 
ATOM 758  C CG  . LYS A 1 138 ? 9.22100   4.23500   -31.14800 1.000 239.46421 ? 138 LYS F CG  1 
ATOM 759  C CD  . LYS A 1 138 ? 9.08300   3.83200   -29.67400 1.000 224.95899 ? 138 LYS F CD  1 
ATOM 760  C CE  . LYS A 1 138 ? 9.63100   2.46400   -29.37600 1.000 214.09500 ? 138 LYS F CE  1 
ATOM 761  N NZ  . LYS A 1 138 ? 9.54600   2.18100   -27.91600 1.000 220.69961 ? 138 LYS F NZ  1 
ATOM 762  N N   . LYS A 1 139 ? 6.41100   7.74200   -32.23900 1.000 271.48298 ? 139 LYS F N   1 
ATOM 763  C CA  . LYS A 1 139 ? 6.08000   9.11000   -32.60500 1.000 266.83667 ? 139 LYS F CA  1 
ATOM 764  C C   . LYS A 1 139 ? 4.83900   9.61000   -31.88500 1.000 264.61248 ? 139 LYS F C   1 
ATOM 765  O O   . LYS A 1 139 ? 4.81100   10.75700  -31.42700 1.000 251.50705 ? 139 LYS F O   1 
ATOM 766  C CB  . LYS A 1 139 ? 5.83300   9.10000   -34.12200 1.000 258.50439 ? 139 LYS F CB  1 
ATOM 767  C CG  . LYS A 1 139 ? 6.99100   8.41300   -34.85000 1.000 256.37847 ? 139 LYS F CG  1 
ATOM 768  C CD  . LYS A 1 139 ? 6.68600   7.88500   -36.25500 1.000 252.24333 ? 139 LYS F CD  1 
ATOM 769  C CE  . LYS A 1 139 ? 7.95500   7.18600   -36.81800 1.000 250.94020 ? 139 LYS F CE  1 
ATOM 770  N NZ  . LYS A 1 139 ? 7.86300   6.49700   -38.15000 1.000 253.80024 ? 139 LYS F NZ  1 
ATOM 771  N N   . THR A 1 140 ? 3.87900   8.71800   -31.63600 1.000 269.37473 ? 140 THR F N   1 
ATOM 772  C CA  . THR A 1 140 ? 2.59100   9.07300   -31.04900 1.000 271.13944 ? 140 THR F CA  1 
ATOM 773  C C   . THR A 1 140 ? 1.97900   7.88600   -30.29000 1.000 264.09129 ? 140 THR F C   1 
ATOM 774  O O   . THR A 1 140 ? 2.43900   6.74700   -30.41300 1.000 260.05655 ? 140 THR F O   1 
ATOM 775  C CB  . THR A 1 140 ? 1.63600   9.52700   -32.19800 1.000 277.06510 ? 140 THR F CB  1 
ATOM 776  O OG1 . THR A 1 140 ? 1.72900   8.62500   -33.32600 1.000 272.03607 ? 140 THR F OG1 1 
ATOM 777  C CG2 . THR A 1 140 ? 1.95500   10.94300  -32.69500 1.000 273.81248 ? 140 THR F CG2 1 
ATOM 778  N N   . ASN A 1 141 ? 0.95100   8.16900   -29.45500 1.000 262.77917 ? 141 ASN F N   1 
ATOM 779  C CA  . ASN A 1 141 ? 0.25500   7.12800   -28.68400 1.000 254.92397 ? 141 ASN F CA  1 
ATOM 780  C C   . ASN A 1 141 ? -0.98800  6.60200   -29.38400 1.000 250.54834 ? 141 ASN F C   1 
ATOM 781  O O   . ASN A 1 141 ? -1.64000  5.68900   -28.86500 1.000 247.09805 ? 141 ASN F O   1 
ATOM 782  C CB  . ASN A 1 141 ? -0.09100  7.59100   -27.24800 1.000 259.61178 ? 141 ASN F CB  1 
ATOM 783  C CG  . ASN A 1 141 ? 1.13900   7.66100   -26.34600 1.000 262.30188 ? 141 ASN F CG  1 
ATOM 784  O OD1 . ASN A 1 141 ? 2.26200   7.84000   -26.82100 1.000 260.89981 ? 141 ASN F OD1 1 
ATOM 785  N ND2 . ASN A 1 141 ? 0.93400   7.47800   -25.04100 1.000 263.17574 ? 141 ASN F ND2 1 
ATOM 786  N N   . GLU A 1 142 ? -1.34900  7.17500   -30.52000 1.000 254.21550 ? 142 GLU F N   1 
ATOM 787  C CA  . GLU A 1 142 ? -2.50500  6.70300   -31.25800 1.000 252.63589 ? 142 GLU F CA  1 
ATOM 788  C C   . GLU A 1 142 ? -2.25500  7.06500   -32.71400 1.000 250.83373 ? 142 GLU F C   1 
ATOM 789  O O   . GLU A 1 142 ? -1.88700  8.21000   -33.01700 1.000 255.03839 ? 142 GLU F O   1 
ATOM 790  C CB  . GLU A 1 142 ? -3.76700  7.42700   -30.73100 1.000 259.15505 ? 142 GLU F CB  1 
ATOM 791  C CG  . GLU A 1 142 ? -5.15800  7.06700   -31.34500 1.000 258.68275 ? 142 GLU F CG  1 
ATOM 792  C CD  . GLU A 1 142 ? -5.93600  5.90200   -30.69300 1.000 251.85336 ? 142 GLU F CD  1 
ATOM 793  O OE1 . GLU A 1 142 ? -5.80200  5.70400   -29.45800 1.000 261.65327 ? 142 GLU F OE1 1 
ATOM 794  O OE2 . GLU A 1 142 ? -6.75300  5.24400   -31.39000 1.000 236.81781 ? 142 GLU F OE2 1 
ATOM 795  N N   . ALA A 1 143 ? -2.45900  6.09500   -33.61300 1.000 243.39282 ? 143 ALA F N   1 
ATOM 796  C CA  . ALA A 1 143 ? -2.25300  6.33900   -35.06100 1.000 242.35062 ? 143 ALA F CA  1 
ATOM 797  C C   . ALA A 1 143 ? -2.89000  5.21100   -35.88000 1.000 238.30739 ? 143 ALA F C   1 
ATOM 798  O O   . ALA A 1 143 ? -3.08400  4.11300   -35.32300 1.000 235.32778 ? 143 ALA F O   1 
ATOM 799  C CB  . ALA A 1 143 ? -0.77900  6.46000   -35.35800 1.000 238.42324 ? 143 ALA F CB  1 
ATOM 800  N N   . VAL A 1 144 ? -3.15500  5.74600   -37.27300 1.000 241.37664 ? 144 VAL F N   1 
ATOM 801  C CA  . VAL A 1 144 ? -3.70900  4.79300   -38.28400 1.000 242.27003 ? 144 VAL F CA  1 
ATOM 802  C C   . VAL A 1 144 ? -2.58400  4.35400   -39.23000 1.000 254.41709 ? 144 VAL F C   1 
ATOM 803  O O   . VAL A 1 144 ? -1.76000  5.21600   -39.59500 1.000 252.32552 ? 144 VAL F O   1 
ATOM 804  C CB  . VAL A 1 144 ? -4.88700  5.41800   -39.05500 1.000 238.46893 ? 144 VAL F CB  1 
ATOM 805  C CG1 . VAL A 1 144 ? -6.15800  5.43700   -38.22000 1.000 235.47015 ? 144 VAL F CG1 1 
ATOM 806  C CG2 . VAL A 1 144 ? -4.55700  6.81400   -39.56300 1.000 240.84112 ? 144 VAL F CG2 1 
ATOM 807  N N   . SER A 1 145 ? -2.56800  3.08400   -39.65400 1.000 264.89836 ? 145 SER F N   1 
ATOM 808  C CA  . SER A 1 145 ? -1.48200  2.60700   -40.55700 1.000 269.88173 ? 145 SER F CA  1 
ATOM 809  C C   . SER A 1 145 ? -1.88500  1.32100   -41.28700 1.000 273.13118 ? 145 SER F C   1 
ATOM 810  O O   . SER A 1 145 ? -2.35900  0.38500   -40.61800 1.000 268.31990 ? 145 SER F O   1 
ATOM 811  C CB  . SER A 1 145 ? -0.20100  2.40100   -39.79400 1.000 262.32466 ? 145 SER F CB  1 
ATOM 812  O OG  . SER A 1 145 ? 0.78800   1.81500   -40.62700 1.000 249.97654 ? 145 SER F OG  1 
ATOM 813  N N   . THR A 1 146 ? -1.68300  1.28200   -42.60700 1.000 279.40851 ? 146 THR F N   1 
ATOM 814  C CA  . THR A 1 146 ? -1.91200  0.03400   -43.38100 1.000 282.50109 ? 146 THR F CA  1 
ATOM 815  C C   . THR A 1 146 ? -0.90200  -1.02400  -42.93000 1.000 279.75360 ? 146 THR F C   1 
ATOM 816  O O   . THR A 1 146 ? 0.30100   -0.70900  -42.87300 1.000 269.39666 ? 146 THR F O   1 
ATOM 817  C CB  . THR A 1 146 ? -1.84100  0.28200   -44.89300 1.000 281.46600 ? 146 THR F CB  1 
ATOM 818  O OG1 . THR A 1 146 ? -1.83400  -0.99200  -45.53800 1.000 282.86032 ? 146 THR F OG1 1 
ATOM 819  C CG2 . THR A 1 146 ? -0.62500  1.07800   -45.31100 1.000 273.80551 ? 146 THR F CG2 1 
ATOM 820  N N   . LEU A 1 147 ? -1.38500  -2.22900  -42.62400 1.000 287.46747 ? 147 LEU F N   1 
ATOM 821  C CA  . LEU A 1 147 ? -0.49100  -3.35200  -42.24000 1.000 288.72062 ? 147 LEU F CA  1 
ATOM 822  C C   . LEU A 1 147 ? -0.06800  -4.09200  -43.51200 1.000 294.70884 ? 147 LEU F C   1 
ATOM 823  O O   . LEU A 1 147 ? -0.70900  -3.86800  -44.55700 1.000 300.12687 ? 147 LEU F O   1 
ATOM 824  C CB  . LEU A 1 147 ? -1.26000  -4.27600  -41.29400 1.000 281.00134 ? 147 LEU F CB  1 
ATOM 825  C CG  . LEU A 1 147 ? -0.44300  -5.34200  -40.56800 1.000 272.13049 ? 147 LEU F CG  1 
ATOM 826  C CD1 . LEU A 1 147 ? -0.17400  -4.92500  -39.13100 1.000 266.31294 ? 147 LEU F CD1 1 
ATOM 827  C CD2 . LEU A 1 147 ? -1.16000  -6.68200  -40.60300 1.000 271.25549 ? 147 LEU F CD2 1 
ATOM 828  N N   . GLY A 1 148 ? 0.96700   -4.93500  -43.43000 1.000 288.70998 ? 148 GLY F N   1 
ATOM 829  C CA  . GLY A 1 148 ? 1.39200   -5.69700  -44.61800 1.000 289.38983 ? 148 GLY F CA  1 
ATOM 830  C C   . GLY A 1 148 ? 0.17200   -6.14400  -45.39800 1.000 294.90837 ? 148 GLY F C   1 
ATOM 831  O O   . GLY A 1 148 ? 0.12300   -5.88100  -46.61500 1.000 292.98277 ? 148 GLY F O   1 
ATOM 832  N N   . CYS A 1 149 ? -0.78400  -6.78800  -44.72600 1.000 301.02954 ? 149 CYS F N   1 
ATOM 833  C CA  . CYS A 1 149 ? -2.05700  -7.16100  -45.39500 1.000 303.74688 ? 149 CYS F CA  1 
ATOM 834  C C   . CYS A 1 149 ? -3.15700  -6.24900  -44.85200 1.000 296.93591 ? 149 CYS F C   1 
ATOM 835  O O   . CYS A 1 149 ? -4.19400  -6.10400  -45.52700 1.000 281.06099 ? 149 CYS F O   1 
ATOM 836  C CB  . CYS A 1 149 ? -2.43800  -8.60700  -45.10300 1.000 311.60601 ? 149 CYS F CB  1 
ATOM 837  S SG  . CYS A 1 149 ? -1.02700  -9.71200  -44.83100 1.000 299.55429 ? 149 CYS F SG  1 
ATOM 838  N N   . GLY A 1 150 ? -2.92700  -5.65300  -43.68000 1.000 300.72998 ? 150 GLY F N   1 
ATOM 839  C CA  . GLY A 1 150 ? -3.96000  -4.81800  -43.04000 1.000 284.46274 ? 150 GLY F CA  1 
ATOM 840  C C   . GLY A 1 150 ? -4.30600  -3.59500  -43.86500 1.000 279.76849 ? 150 GLY F C   1 
ATOM 841  O O   . GLY A 1 150 ? -3.38000  -2.86800  -44.27000 1.000 288.42508 ? 150 GLY F O   1 
ATOM 842  N N   . PRO A 1 151 ? -5.60300  -3.33300  -44.12900 1.000 268.53705 ? 151 PRO F N   1 
ATOM 843  C CA  . PRO A 1 151 ? -6.01100  -2.13100  -44.84800 1.000 272.20736 ? 151 PRO F CA  1 
ATOM 844  C C   . PRO A 1 151 ? -6.08100  -0.95000  -43.87200 1.000 283.21295 ? 151 PRO F C   1 
ATOM 845  O O   . PRO A 1 151 ? -7.17600  -0.58300  -43.48800 1.000 287.10317 ? 151 PRO F O   1 
ATOM 846  C CB  . PRO A 1 151 ? -7.40700  -2.50400  -45.36300 1.000 263.19788 ? 151 PRO F CB  1 
ATOM 847  C CG  . PRO A 1 151 ? -7.94400  -3.47500  -44.32900 1.000 268.13983 ? 151 PRO F CG  1 
ATOM 848  C CD  . PRO A 1 151 ? -6.73300  -4.18900  -43.76600 1.000 261.43575 ? 151 PRO F CD  1 
ATOM 849  N N   . ARG A 1 152 ? -4.92300  -0.39800  -43.49600 1.000 290.65984 ? 152 ARG F N   1 
ATOM 850  C CA  . ARG A 1 152 ? -4.86900  0.75200   -42.55000 1.000 287.14601 ? 152 ARG F CA  1 
ATOM 851  C C   . ARG A 1 152 ? -5.53900  0.35400   -41.23000 1.000 275.88002 ? 152 ARG F C   1 
ATOM 852  O O   . ARG A 1 152 ? -6.70300  0.74200   -41.01900 1.000 282.79847 ? 152 ARG F O   1 
ATOM 853  C CB  . ARG A 1 152 ? -5.50100  2.00200   -43.17200 1.000 286.11776 ? 152 ARG F CB  1 
ATOM 854  C CG  . ARG A 1 152 ? -5.46400  3.23200   -42.27600 1.000 273.31423 ? 152 ARG F CG  1 
ATOM 855  C CD  . ARG A 1 152 ? -6.03000  4.47200   -42.94200 1.000 256.37347 ? 152 ARG F CD  1 
ATOM 856  N NE  . ARG A 1 152 ? -7.45300  4.34400   -43.23000 1.000 269.58258 ? 152 ARG F NE  1 
ATOM 857  C CZ  . ARG A 1 152 ? -8.42500  4.57100   -42.35200 1.000 273.08385 ? 152 ARG F CZ  1 
ATOM 858  N NH1 . ARG A 1 152 ? -8.75400  5.81100   -42.03500 1.000 269.71779 ? 152 ARG F NH1 1 
ATOM 859  N NH2 . ARG A 1 152 ? -9.06600  3.55700   -41.79600 1.000 277.19620 ? 152 ARG F NH2 1 
ATOM 860  N N   . VAL A 1 153 ? -4.82600  -0.38600  -40.37800 1.000 258.09331 ? 153 VAL F N   1 
ATOM 861  C CA  . VAL A 1 153 ? -5.41100  -0.84900  -39.08400 1.000 228.60447 ? 153 VAL F CA  1 
ATOM 862  C C   . VAL A 1 153 ? -5.14000  0.20700   -38.00600 1.000 222.84805 ? 153 VAL F C   1 
ATOM 863  O O   . VAL A 1 153 ? -4.34600  1.13200   -38.27200 1.000 233.08229 ? 153 VAL F O   1 
ATOM 864  C CB  . VAL A 1 153 ? -4.84700  -2.22500  -38.68500 1.000 218.42540 ? 153 VAL F CB  1 
ATOM 865  C CG1 . VAL A 1 153 ? -5.27400  -3.30700  -39.66400 1.000 222.07352 ? 153 VAL F CG1 1 
ATOM 866  C CG2 . VAL A 1 153 ? -3.33300  -2.19200  -38.55200 1.000 232.39204 ? 153 VAL F CG2 1 
ATOM 867  N N   . LEU A 1 154 ? -5.78000  0.07300   -36.83800 1.000 211.48207 ? 154 LEU F N   1 
ATOM 868  C CA  . LEU A 1 154 ? -5.59800  1.07300   -35.75100 1.000 213.74077 ? 154 LEU F CA  1 
ATOM 869  C C   . LEU A 1 154 ? -4.52900  0.60300   -34.76300 1.000 219.08851 ? 154 LEU F C   1 
ATOM 870  O O   . LEU A 1 154 ? -4.53200  -0.59500  -34.41500 1.000 217.30796 ? 154 LEU F O   1 
ATOM 871  C CB  . LEU A 1 154 ? -6.92600  1.29400   -35.02200 1.000 211.88561 ? 154 LEU F CB  1 
ATOM 872  C CG  . LEU A 1 154 ? -6.93800  2.49500   -34.07700 1.000 210.24219 ? 154 LEU F CG  1 
ATOM 873  C CD1 . LEU A 1 154 ? -6.35900  3.72700   -34.75300 1.000 214.42868 ? 154 LEU F CD1 1 
ATOM 874  C CD2 . LEU A 1 154 ? -8.34100  2.78000   -33.56900 1.000 209.76936 ? 154 LEU F CD2 1 
ATOM 875  N N   . ALA A 1 155 ? -3.67300  1.52400   -34.31600 1.000 225.28491 ? 155 ALA F N   1 
ATOM 876  C CA  . ALA A 1 155 ? -2.64000  1.19400   -33.35000 1.000 222.67885 ? 155 ALA F CA  1 
ATOM 877  C C   . ALA A 1 155 ? -2.74900  2.16400   -32.18000 1.000 221.14256 ? 155 ALA F C   1 
ATOM 878  O O   . ALA A 1 155 ? -2.76100  3.38800   -32.37900 1.000 229.14227 ? 155 ALA F O   1 
ATOM 879  C CB  . ALA A 1 155 ? -1.25000  1.24400   -33.98700 1.000 231.39900 ? 155 ALA F CB  1 
ATOM 880  N N   . THR A 1 156 ? -2.69900  1.63700   -30.96500 1.000 212.07952 ? 156 THR F N   1 
ATOM 881  C CA  . THR A 1 156 ? -2.90200  2.47500   -29.79800 1.000 223.08860 ? 156 THR F CA  1 
ATOM 882  C C   . THR A 1 156 ? -1.77000  2.11500   -28.88800 1.000 222.65489 ? 156 THR F C   1 
ATOM 883  O O   . THR A 1 156 ? -1.44600  0.92900   -28.74000 1.000 216.72343 ? 156 THR F O   1 
ATOM 884  C CB  . THR A 1 156 ? -4.21800  2.20200   -29.04300 1.000 222.00633 ? 156 THR F CB  1 
ATOM 885  O OG1 . THR A 1 156 ? -5.35400  2.36300   -29.89500 1.000 224.16673 ? 156 THR F OG1 1 
ATOM 886  C CG2 . THR A 1 156 ? -4.35300  3.08400   -27.79200 1.000 221.91805 ? 156 THR F CG2 1 
ATOM 887  N N   . ALA A 1 157 ? -1.11100  3.13600   -28.36100 1.000 231.77316 ? 157 ALA F N   1 
ATOM 888  C CA  . ALA A 1 157 ? -0.04300  2.87000   -27.42300 1.000 236.17213 ? 157 ALA F CA  1 
ATOM 889  C C   . ALA A 1 157 ? -0.41100  3.19900   -25.98100 1.000 236.33442 ? 157 ALA F C   1 
ATOM 890  O O   . ALA A 1 157 ? -1.12600  4.17400   -25.70300 1.000 232.81743 ? 157 ALA F O   1 
ATOM 891  C CB  . ALA A 1 157 ? 1.19000   3.68500   -27.81000 1.000 242.45361 ? 157 ALA F CB  1 
ATOM 892  N N   . VAL A 1 158 ? 0.02200   2.31900   -25.07700 1.000 234.43831 ? 158 VAL F N   1 
ATOM 893  C CA  . VAL A 1 158 ? -0.10600  2.50500   -23.64400 1.000 230.85018 ? 158 VAL F CA  1 
ATOM 894  C C   . VAL A 1 158 ? 1.27700   2.16700   -23.08300 1.000 231.23811 ? 158 VAL F C   1 
ATOM 895  O O   . VAL A 1 158 ? 1.62900   0.98500   -22.95500 1.000 226.99724 ? 158 VAL F O   1 
ATOM 896  C CB  . VAL A 1 158 ? -1.22900  1.68100   -23.01700 1.000 225.58331 ? 158 VAL F CB  1 
ATOM 897  C CG1 . VAL A 1 158 ? -1.23300  1.85100   -21.54300 1.000 230.42256 ? 158 VAL F CG1 1 
ATOM 898  C CG2 . VAL A 1 158 ? -2.57700  2.18700   -23.52000 1.000 220.58483 ? 158 VAL F CG2 1 
ATOM 899  N N   . ARG A 1 159 ? 2.02200   3.19500   -22.67400 1.000 237.56623 ? 159 ARG F N   1 
ATOM 900  C CA  . ARG A 1 159 ? 3.45600   3.10900   -22.39700 1.000 240.56191 ? 159 ARG F CA  1 
ATOM 901  C C   . ARG A 1 159 ? 3.76000   3.46000   -20.95300 1.000 249.05121 ? 159 ARG F C   1 
ATOM 902  O O   . ARG A 1 159 ? 4.92700   3.46700   -20.55700 1.000 254.51952 ? 159 ARG F O   1 
ATOM 903  C CB  . ARG A 1 159 ? 4.27100   4.01200   -23.32600 1.000 238.84565 ? 159 ARG F CB  1 
ATOM 904  C CG  . ARG A 1 159 ? 3.89400   3.92500   -24.76400 1.000 239.33099 ? 159 ARG F CG  1 
ATOM 905  C CD  . ARG A 1 159 ? 4.94500   4.63700   -25.54200 1.000 246.00771 ? 159 ARG F CD  1 
ATOM 906  N NE  . ARG A 1 159 ? 4.35400   5.26300   -26.71500 1.000 253.66991 ? 159 ARG F NE  1 
ATOM 907  C CZ  . ARG A 1 159 ? 4.99100   6.12800   -27.49100 1.000 265.86159 ? 159 ARG F CZ  1 
ATOM 908  N NH1 . ARG A 1 159 ? 6.24600   6.48800   -27.24600 1.000 276.35107 ? 159 ARG F NH1 1 
ATOM 909  N NH2 . ARG A 1 159 ? 4.35200   6.65700   -28.52700 1.000 267.15800 ? 159 ARG F NH2 1 
ATOM 910  N N   . GLU A 1 160 ? 2.72600   3.70900   -20.14800 1.000 248.57214 ? 160 GLU F N   1 
ATOM 911  C CA  . GLU A 1 160 ? 2.91200   4.22900   -18.80100 1.000 254.43507 ? 160 GLU F CA  1 
ATOM 912  C C   . GLU A 1 160 ? 3.80200   3.29500   -17.99800 1.000 250.64506 ? 160 GLU F C   1 
ATOM 913  O O   . GLU A 1 160 ? 4.69600   3.74700   -17.26900 1.000 259.35652 ? 160 GLU F O   1 
ATOM 914  C CB  . GLU A 1 160 ? 1.56100   4.38400   -18.07000 1.000 263.40806 ? 160 GLU F CB  1 
ATOM 915  C CG  . GLU A 1 160 ? 0.51900   5.45900   -18.56500 1.000 267.22426 ? 160 GLU F CG  1 
ATOM 916  C CD  . GLU A 1 160 ? -0.35100  5.06800   -19.80300 1.000 261.16936 ? 160 GLU F CD  1 
ATOM 917  O OE1 . GLU A 1 160 ? 0.07900   5.27600   -20.96300 1.000 266.31966 ? 160 GLU F OE1 1 
ATOM 918  O OE2 . GLU A 1 160 ? -1.52700  4.63200   -19.59700 1.000 251.38028 ? 160 GLU F OE2 1 
ATOM 919  N N   . LEU A 1 161 ? 3.57200   1.99000   -18.11000 1.000 239.88532 ? 161 LEU F N   1 
ATOM 920  C CA  . LEU A 1 161 ? 4.36100   1.05800   -17.32600 1.000 243.79308 ? 161 LEU F CA  1 
ATOM 921  C C   . LEU A 1 161 ? 5.85000   1.08800   -17.68200 1.000 252.14216 ? 161 LEU F C   1 
ATOM 922  O O   . LEU A 1 161 ? 6.67800   1.06100   -16.77100 1.000 252.53311 ? 161 LEU F O   1 
ATOM 923  C CB  . LEU A 1 161 ? 3.79900   -0.35700  -17.51100 1.000 238.53337 ? 161 LEU F CB  1 
ATOM 924  C CG  . LEU A 1 161 ? 4.39900   -1.51300  -16.70600 1.000 235.37972 ? 161 LEU F CG  1 
ATOM 925  C CD1 . LEU A 1 161 ? 4.25700   -1.25600  -15.21900 1.000 239.40015 ? 161 LEU F CD1 1 
ATOM 926  C CD2 . LEU A 1 161 ? 3.78500   -2.85100  -17.08500 1.000 232.34087 ? 161 LEU F CD2 1 
ATOM 927  N N   . LYS A 1 162 ? 6.23400   1.12700   -18.97800 1.000 257.03780 ? 162 LYS F N   1 
ATOM 928  C CA  . LYS A 1 162 ? 7.67800   1.24600   -19.28500 1.000 262.92737 ? 162 LYS F CA  1 
ATOM 929  C C   . LYS A 1 162 ? 8.29400   2.55300   -18.80300 1.000 266.71611 ? 162 LYS F C   1 
ATOM 930  O O   . LYS A 1 162 ? 9.38700   2.54100   -18.21800 1.000 262.67398 ? 162 LYS F O   1 
ATOM 931  C CB  . LYS A 1 162 ? 8.01500   1.00900   -20.77400 1.000 260.95860 ? 162 LYS F CB  1 
ATOM 932  C CG  . LYS A 1 162 ? 9.57000   1.15300   -21.17900 1.000 252.10956 ? 162 LYS F CG  1 
ATOM 933  C CD  . LYS A 1 162 ? 9.89400   0.58800   -22.62700 1.000 232.27160 ? 162 LYS F CD  1 
ATOM 934  C CE  . LYS A 1 162 ? 11.03600  1.20700   -23.41400 1.000 213.24108 ? 162 LYS F CE  1 
ATOM 935  N NZ  . LYS A 1 162 ? 10.79400  2.61100   -23.70800 1.000 227.01482 ? 162 LYS F NZ  1 
ATOM 936  N N   . ASP A 1 163 ? 7.59500   3.68200   -18.99700 1.000 273.29719 ? 163 ASP F N   1 
ATOM 937  C CA  . ASP A 1 163 ? 8.17900   4.96100   -18.58700 1.000 277.38521 ? 163 ASP F CA  1 
ATOM 938  C C   . ASP A 1 163 ? 8.37000   4.99600   -17.07700 1.000 271.70338 ? 163 ASP F C   1 
ATOM 939  O O   . ASP A 1 163 ? 9.37600   5.52100   -16.57900 1.000 270.03177 ? 163 ASP F O   1 
ATOM 940  C CB  . ASP A 1 163 ? 7.22800   6.11600   -18.99200 1.000 281.91567 ? 163 ASP F CB  1 
ATOM 941  C CG  . ASP A 1 163 ? 7.12600   6.33200   -20.52900 1.000 288.14354 ? 163 ASP F CG  1 
ATOM 942  O OD1 . ASP A 1 163 ? 7.91800   5.74300   -21.29500 1.000 291.59934 ? 163 ASP F OD1 1 
ATOM 943  O OD2 . ASP A 1 163 ? 6.21500   7.09000   -20.96200 1.000 282.27004 ? 163 ASP F OD2 1 
ATOM 944  N N   . PHE A 1 164 ? 7.38800   4.46700   -16.35000 1.000 271.63717 ? 164 PHE F N   1 
ATOM 945  C CA  . PHE A 1 164 ? 7.54800   4.39200   -14.87800 1.000 276.07104 ? 164 PHE F CA  1 
ATOM 946  C C   . PHE A 1 164 ? 8.68200   3.41200   -14.58000 1.000 265.82053 ? 164 PHE F C   1 
ATOM 947  O O   . PHE A 1 164 ? 9.58500   3.74900   -13.78900 1.000 267.80911 ? 164 PHE F O   1 
ATOM 948  C CB  . PHE A 1 164 ? 6.22900   4.00100   -14.20900 1.000 286.92868 ? 164 PHE F CB  1 
ATOM 949  C CG  . PHE A 1 164 ? 5.29900   5.16600   -13.98600 1.000 308.15584 ? 164 PHE F CG  1 
ATOM 950  C CD1 . PHE A 1 164 ? 4.77800   5.87400   -15.05600 1.000 307.69962 ? 164 PHE F CD1 1 
ATOM 951  C CD2 . PHE A 1 164 ? 4.97600   5.58000   -12.70400 1.000 322.62294 ? 164 PHE F CD2 1 
ATOM 952  C CE1 . PHE A 1 164 ? 3.93400   6.95300   -14.85100 1.000 322.98632 ? 164 PHE F CE1 1 
ATOM 953  C CE2 . PHE A 1 164 ? 4.13600   6.66200   -12.49900 1.000 333.66184 ? 164 PHE F CE2 1 
ATOM 954  C CZ  . PHE A 1 164 ? 3.61500   7.34600   -13.57200 1.000 338.01337 ? 164 PHE F CZ  1 
ATOM 955  N N   . VAL A 1 165 ? 8.64300   2.24600   -15.22800 1.000 256.89577 ? 165 VAL F N   1 
ATOM 956  C CA  . VAL A 1 165 ? 9.67300   1.25200   -14.97400 1.000 250.96596 ? 165 VAL F CA  1 
ATOM 957  C C   . VAL A 1 165 ? 11.01000  1.84200   -15.31500 1.000 257.51485 ? 165 VAL F C   1 
ATOM 958  O O   . VAL A 1 165 ? 11.99900  1.58600   -14.63900 1.000 259.85087 ? 165 VAL F O   1 
ATOM 959  C CB  . VAL A 1 165 ? 9.45900   -0.02000  -15.78600 1.000 238.45707 ? 165 VAL F CB  1 
ATOM 960  C CG1 . VAL A 1 165 ? 10.75500  -0.79600  -15.77400 1.000 224.91240 ? 165 VAL F CG1 1 
ATOM 961  C CG2 . VAL A 1 165 ? 8.40200   -0.80500  -15.11200 1.000 242.63540 ? 165 VAL F CG2 1 
ATOM 962  N N   . SER A 1 166 ? 11.08200  2.53800   -16.44200 1.000 261.80011 ? 166 SER F N   1 
ATOM 963  C CA  . SER A 1 166 ? 12.34900  3.10600   -16.88200 1.000 273.32552 ? 166 SER F CA  1 
ATOM 964  C C   . SER A 1 166 ? 12.73600  4.33300   -16.02500 1.000 278.88785 ? 166 SER F C   1 
ATOM 965  O O   . SER A 1 166 ? 13.86800  4.40300   -15.52200 1.000 285.80426 ? 166 SER F O   1 
ATOM 966  C CB  . SER A 1 166 ? 12.27900  3.40500   -18.38500 1.000 275.43817 ? 166 SER F CB  1 
ATOM 967  O OG  . SER A 1 166 ? 13.47100  3.98400   -18.88800 1.000 290.07718 ? 166 SER F OG  1 
ATOM 968  N N   . LYS A 1 167 ? 11.83900  5.33600   -15.87300 1.000 272.67599 ? 167 LYS F N   1 
ATOM 969  C CA  . LYS A 1 167 ? 12.25100  6.59800   -15.22900 1.000 264.56013 ? 167 LYS F CA  1 
ATOM 970  C C   . LYS A 1 167 ? 12.25900  6.53000   -13.70700 1.000 270.98266 ? 167 LYS F C   1 
ATOM 971  O O   . LYS A 1 167 ? 13.33900  6.44800   -13.11100 1.000 271.10712 ? 167 LYS F O   1 
ATOM 972  C CB  . LYS A 1 167 ? 11.40100  7.80000   -15.61800 1.000 251.21594 ? 167 LYS F CB  1 
ATOM 973  C CG  . LYS A 1 167 ? 11.45800  8.13300   -17.04300 1.000 249.28840 ? 167 LYS F CG  1 
ATOM 974  C CD  . LYS A 1 167 ? 10.56600  9.27400   -17.38300 1.000 247.34788 ? 167 LYS F CD  1 
ATOM 975  C CE  . LYS A 1 167 ? 10.71400  9.49800   -18.86200 1.000 249.10510 ? 167 LYS F CE  1 
ATOM 976  N NZ  . LYS A 1 167 ? 9.82100   10.52000  -19.39100 1.000 253.14650 ? 167 LYS F NZ  1 
ATOM 977  N N   . ASN A 1 168 ? 11.08100  6.66200   -13.06500 1.000 275.86865 ? 168 ASN F N   1 
ATOM 978  C CA  . ASN A 1 168 ? 11.03800  6.79900   -11.60200 1.000 282.16313 ? 168 ASN F CA  1 
ATOM 979  C C   . ASN A 1 168 ? 11.53300  5.51600   -10.93100 1.000 278.85029 ? 168 ASN F C   1 
ATOM 980  O O   . ASN A 1 168 ? 12.33800  5.56500   -9.99000  1.000 280.54606 ? 168 ASN F O   1 
ATOM 981  C CB  . ASN A 1 168 ? 9.64300   7.18400   -11.04500 1.000 275.80029 ? 168 ASN F CB  1 
ATOM 982  C CG  . ASN A 1 168 ? 9.03800   8.48500   -11.63500 1.000 265.69889 ? 168 ASN F CG  1 
ATOM 983  O OD1 . ASN A 1 168 ? 9.73200   9.34800   -12.16100 1.000 273.76022 ? 168 ASN F OD1 1 
ATOM 984  N ND2 . ASN A 1 168 ? 7.75300   8.68500   -11.36600 1.000 250.73973 ? 168 ASN F ND2 1 
ATOM 985  N N   . LEU A 1 169 ? 10.94900  4.36800   -11.30800 1.000 272.69027 ? 169 LEU F N   1 
ATOM 986  C CA  . LEU A 1 169 ? 11.20400  3.11200   -10.59900 1.000 268.73300 ? 169 LEU F CA  1 
ATOM 987  C C   . LEU A 1 169 ? 12.63100  2.57100   -10.86000 1.000 273.69175 ? 169 LEU F C   1 
ATOM 988  O O   . LEU A 1 169 ? 13.33800  2.21200   -9.90700  1.000 278.11712 ? 169 LEU F O   1 
ATOM 989  C CB  . LEU A 1 169 ? 10.06800  2.13100   -10.95600 1.000 259.65873 ? 169 LEU F CB  1 
ATOM 990  C CG  . LEU A 1 169 ? 9.75700   0.65900   -10.69500 1.000 252.50536 ? 169 LEU F CG  1 
ATOM 991  C CD1 . LEU A 1 169 ? 9.62200   0.38100   -9.20900  1.000 247.31322 ? 169 LEU F CD1 1 
ATOM 992  C CD2 . LEU A 1 169 ? 8.42400   0.38100   -11.36800 1.000 241.49199 ? 169 LEU F CD2 1 
ATOM 993  N N   . THR A 1 170 ? 13.09900  2.52900   -12.13300 1.000 273.42017 ? 170 THR F N   1 
ATOM 994  C CA  . THR A 1 170 ? 14.42900  1.94100   -12.41500 1.000 269.64594 ? 170 THR F CA  1 
ATOM 995  C C   . THR A 1 170 ? 15.55500  2.73300   -11.74400 1.000 277.81352 ? 170 THR F C   1 
ATOM 996  O O   . THR A 1 170 ? 16.58200  2.14300   -11.38600 1.000 285.43032 ? 170 THR F O   1 
ATOM 997  C CB  . THR A 1 170 ? 14.73200  1.74400   -13.92000 1.000 261.17983 ? 170 THR F CB  1 
ATOM 998  O OG1 . THR A 1 170 ? 13.84200  0.75500   -14.47200 1.000 255.74479 ? 170 THR F OG1 1 
ATOM 999  C CG2 . THR A 1 170 ? 16.17200  1.25700   -14.15800 1.000 251.97059 ? 170 THR F CG2 1 
ATOM 1000 N N   . ARG A 1 171 ? 15.45000  4.06800   -11.64000 1.000 278.43334 ? 171 ARG F N   1 
ATOM 1001 C CA  . ARG A 1 171 ? 16.52400  4.74200   -10.91300 1.000 286.42075 ? 171 ARG F CA  1 
ATOM 1002 C C   . ARG A 1 171 ? 16.53700  4.30800   -9.43600  1.000 292.37613 ? 171 ARG F C   1 
ATOM 1003 O O   . ARG A 1 171 ? 17.60500  4.29000   -8.81200  1.000 299.48994 ? 171 ARG F O   1 
ATOM 1004 C CB  . ARG A 1 171 ? 16.48900  6.26600   -11.06900 1.000 280.86132 ? 171 ARG F CB  1 
ATOM 1005 C CG  . ARG A 1 171 ? 16.76400  6.81200   -12.48700 1.000 283.17985 ? 171 ARG F CG  1 
ATOM 1006 C CD  . ARG A 1 171 ? 16.03300  8.13100   -12.70100 1.000 284.69128 ? 171 ARG F CD  1 
ATOM 1007 N NE  . ARG A 1 171 ? 16.48400  9.05200   -11.65700 1.000 279.68228 ? 171 ARG F NE  1 
ATOM 1008 C CZ  . ARG A 1 171 ? 16.07900  10.30800  -11.48000 1.000 288.37011 ? 171 ARG F CZ  1 
ATOM 1009 N NH1 . ARG A 1 171 ? 15.19000  10.87200  -12.28300 1.000 285.86448 ? 171 ARG F NH1 1 
ATOM 1010 N NH2 . ARG A 1 171 ? 16.51200  10.98700  -10.41500 1.000 297.21353 ? 171 ARG F NH2 1 
ATOM 1011 N N   . ALA A 1 172 ? 15.36600  4.04700   -8.82600  1.000 285.10738 ? 172 ALA F N   1 
ATOM 1012 C CA  . ALA A 1 172 ? 15.34200  3.63500   -7.41800  1.000 281.30634 ? 172 ALA F CA  1 
ATOM 1013 C C   . ALA A 1 172 ? 15.78300  2.17000   -7.24800  1.000 279.17227 ? 172 ALA F C   1 
ATOM 1014 O O   . ALA A 1 172 ? 16.21500  1.78200   -6.14900  1.000 268.11331 ? 172 ALA F O   1 
ATOM 1015 C CB  . ALA A 1 172 ? 13.95300  3.85900   -6.81900  1.000 269.31691 ? 172 ALA F CB  1 
ATOM 1016 N N   . ILE A 1 173 ? 15.73400  1.37700   -8.33100  1.000 283.97203 ? 173 ILE F N   1 
ATOM 1017 C CA  . ILE A 1 173 ? 16.18100  -0.02300  -8.34000  1.000 283.26547 ? 173 ILE F CA  1 
ATOM 1018 C C   . ILE A 1 173 ? 17.59900  -0.14100  -8.88600  1.000 296.96319 ? 173 ILE F C   1 
ATOM 1019 O O   . ILE A 1 173 ? 18.06400  -1.25800  -9.16000  1.000 301.62471 ? 173 ILE F O   1 
ATOM 1020 C CB  . ILE A 1 173 ? 15.22900  -0.97500  -9.10800  1.000 276.38522 ? 173 ILE F CB  1 
ATOM 1021 C CG1 . ILE A 1 173 ? 13.77900  -0.77400  -8.70700  1.000 279.06911 ? 173 ILE F CG1 1 
ATOM 1022 C CG2 . ILE A 1 173 ? 15.52500  -2.47000  -8.84800  1.000 267.30108 ? 173 ILE F CG2 1 
ATOM 1023 C CD1 . ILE A 1 173 ? 13.55600  -1.11000  -7.25500  1.000 278.01222 ? 173 ILE F CD1 1 
ATOM 1024 N N   . ASN A 1 174 ? 18.31800  0.98400   -9.03600  1.000 304.42533 ? 174 ASN F N   1 
ATOM 1025 C CA  . ASN A 1 174 ? 19.69200  0.75100   -9.45500  1.000 311.17137 ? 174 ASN F CA  1 
ATOM 1026 C C   . ASN A 1 174 ? 20.39000  0.27300   -8.21300  1.000 305.69598 ? 174 ASN F C   1 
ATOM 1027 O O   . ASN A 1 174 ? 19.93300  0.52300   -7.08200  1.000 293.52344 ? 174 ASN F O   1 
ATOM 1028 C CB  . ASN A 1 174 ? 20.48800  1.99300   -9.97100  1.000 307.54933 ? 174 ASN F CB  1 
ATOM 1029 C CG  . ASN A 1 174 ? 20.30200  2.32000   -11.47500 1.000 304.92352 ? 174 ASN F CG  1 
ATOM 1030 O OD1 . ASN A 1 174 ? 19.77200  1.53000   -12.25200 1.000 305.57883 ? 174 ASN F OD1 1 
ATOM 1031 N ND2 . ASN A 1 174 ? 20.86000  3.46000   -11.89100 1.000 298.74592 ? 174 ASN F ND2 1 
ATOM 1032 N N   . LYS A 1 175 ? 21.48900  -0.43500  -8.44000  1.000 308.64959 ? 175 LYS F N   1 
ATOM 1033 C CA  . LYS A 1 175 ? 22.28900  -0.94400  -7.36400  1.000 307.15596 ? 175 LYS F CA  1 
ATOM 1034 C C   . LYS A 1 175 ? 21.52100  -2.00000  -6.54000  1.000 299.18125 ? 175 LYS F C   1 
ATOM 1035 O O   . LYS A 1 175 ? 21.88900  -2.28000  -5.39300  1.000 303.35501 ? 175 LYS F O   1 
ATOM 1036 C CB  . LYS A 1 175 ? 22.60900  0.31900   -6.53700  1.000 317.38567 ? 175 LYS F CB  1 
ATOM 1037 C CG  . LYS A 1 175 ? 23.50500  1.34500   -7.28500  1.000 310.24289 ? 175 LYS F CG  1 
ATOM 1038 C CD  . LYS A 1 175 ? 23.87600  2.58800   -6.44400  1.000 302.61587 ? 175 LYS F CD  1 
ATOM 1039 C CE  . LYS A 1 175 ? 22.63200  3.44000   -6.06500  1.000 291.81732 ? 175 LYS F CE  1 
ATOM 1040 N NZ  . LYS A 1 175 ? 21.89300  4.00100   -7.22900  1.000 276.45831 ? 175 LYS F NZ  1 
ATOM 1041 N N   . ASN A 1 176 ? 20.46800  -2.63400  -7.10300  1.000 291.08223 ? 176 ASN F N   1 
ATOM 1042 C CA  . ASN A 1 176 ? 19.91200  -3.91000  -6.61800  1.000 278.80802 ? 176 ASN F CA  1 
ATOM 1043 C C   . ASN A 1 176 ? 19.31500  -3.75300  -5.21500  1.000 276.95834 ? 176 ASN F C   1 
ATOM 1044 O O   . ASN A 1 176 ? 19.14800  -4.74200  -4.49200  1.000 277.17910 ? 176 ASN F O   1 
ATOM 1045 C CB  . ASN A 1 176 ? 20.91100  -5.09100  -6.63000  1.000 266.95415 ? 176 ASN F CB  1 
ATOM 1046 C CG  . ASN A 1 176 ? 21.58300  -5.32900  -7.97800  1.000 260.83439 ? 176 ASN F CG  1 
ATOM 1047 O OD1 . ASN A 1 176 ? 21.35100  -4.62500  -8.96000  1.000 264.23771 ? 176 ASN F OD1 1 
ATOM 1048 N ND2 . ASN A 1 176 ? 22.37200  -6.38600  -8.03600  1.000 258.87676 ? 176 ASN F ND2 1 
ATOM 1049 N N   . LYS A 1 177 ? 18.96300  -2.52100  -4.82800  1.000 277.25224 ? 177 LYS F N   1 
ATOM 1050 C CA  . LYS A 1 177 ? 18.35700  -2.24000  -3.52900  1.000 274.35102 ? 177 LYS F CA  1 
ATOM 1051 C C   . LYS A 1 177 ? 16.85400  -1.99600  -3.51800  1.000 270.47068 ? 177 LYS F C   1 
ATOM 1052 O O   . LYS A 1 177 ? 16.38200  -0.95100  -3.98500  1.000 266.27785 ? 177 LYS F O   1 
ATOM 1053 C CB  . LYS A 1 177 ? 19.07700  -1.00500  -3.00400  1.000 282.92987 ? 177 LYS F CB  1 
ATOM 1054 C CG  . LYS A 1 177 ? 18.52900  -0.31300  -1.77900  1.000 288.90099 ? 177 LYS F CG  1 
ATOM 1055 C CD  . LYS A 1 177 ? 18.54100  -1.15300  -0.51700  1.000 288.05311 ? 177 LYS F CD  1 
ATOM 1056 C CE  . LYS A 1 177 ? 17.56200  -0.54900  0.49600   1.000 291.51900 ? 177 LYS F CE  1 
ATOM 1057 N NZ  . LYS A 1 177 ? 17.74400  0.93900   0.70700   1.000 282.80930 ? 177 LYS F NZ  1 
ATOM 1058 N N   . CYS A 1 178 ? 16.10400  -2.99800  -3.02800  1.000 272.48955 ? 178 CYS F N   1 
ATOM 1059 C CA  . CYS A 1 178 ? 14.65100  -2.92800  -3.02000  1.000 276.87083 ? 178 CYS F CA  1 
ATOM 1060 C C   . CYS A 1 178 ? 13.98700  -2.69200  -1.66200  1.000 274.46612 ? 178 CYS F C   1 
ATOM 1061 O O   . CYS A 1 178 ? 12.82800  -2.27200  -1.65300  1.000 274.44284 ? 178 CYS F O   1 
ATOM 1062 C CB  . CYS A 1 178 ? 14.04000  -4.16600  -3.68600  1.000 276.58759 ? 178 CYS F CB  1 
ATOM 1063 S SG  . CYS A 1 178 ? 14.55600  -4.28100  -5.42100  1.000 295.00326 ? 178 CYS F SG  1 
ATOM 1064 N N   . ASP A 1 179 ? 14.63800  -2.94200  -0.51400  1.000 272.15466 ? 179 ASP F N   1 
ATOM 1065 C CA  . ASP A 1 179 ? 13.96400  -2.62000  0.75300   1.000 273.55225 ? 179 ASP F CA  1 
ATOM 1066 C C   . ASP A 1 179 ? 14.11500  -1.12700  1.01800   1.000 268.42453 ? 179 ASP F C   1 
ATOM 1067 O O   . ASP A 1 179 ? 14.42400  -0.70200  2.12800   1.000 268.87254 ? 179 ASP F O   1 
ATOM 1068 C CB  . ASP A 1 179 ? 14.54800  -3.37800  1.94500   1.000 276.54090 ? 179 ASP F CB  1 
ATOM 1069 C CG  . ASP A 1 179 ? 13.76700  -4.60400  2.31700   1.000 270.54490 ? 179 ASP F CG  1 
ATOM 1070 O OD1 . ASP A 1 179 ? 12.85800  -4.97800  1.56800   1.000 275.97542 ? 179 ASP F OD1 1 
ATOM 1071 O OD2 . ASP A 1 179 ? 14.01500  -5.13600  3.42700   1.000 281.50730 ? 179 ASP F OD2 1 
ATOM 1072 N N   . ILE A 1 180 ? 13.69700  -0.31600  0.06600   1.000 262.66057 ? 180 ILE F N   1 
ATOM 1073 C CA  . ILE A 1 180 ? 13.98100  1.08500   0.31000   1.000 259.90970 ? 180 ILE F CA  1 
ATOM 1074 C C   . ILE A 1 180 ? 12.92000  1.57400   1.27200   1.000 264.63619 ? 180 ILE F C   1 
ATOM 1075 O O   . ILE A 1 180 ? 11.88700  0.91200   1.47800   1.000 260.16018 ? 180 ILE F O   1 
ATOM 1076 C CB  . ILE A 1 180 ? 14.03000  1.93100   -0.97900  1.000 261.40618 ? 180 ILE F CB  1 
ATOM 1077 C CG1 . ILE A 1 180 ? 12.69100  1.90900   -1.71900  1.000 267.96062 ? 180 ILE F CG1 1 
ATOM 1078 C CG2 . ILE A 1 180 ? 15.20500  1.53400   -1.87500  1.000 261.52425 ? 180 ILE F CG2 1 
ATOM 1079 C CD1 . ILE A 1 180 ? 12.66000  2.85300   -2.89600  1.000 272.36287 ? 180 ILE F CD1 1 
ATOM 1080 N N   . PRO A 1 181 ? 13.22600  2.63900   2.00100   1.000 272.84704 ? 181 PRO F N   1 
ATOM 1081 C CA  . PRO A 1 181 ? 12.24500  3.20300   2.92900   1.000 284.06538 ? 181 PRO F CA  1 
ATOM 1082 C C   . PRO A 1 181 ? 11.08800  3.88500   2.20500   1.000 290.53544 ? 181 PRO F C   1 
ATOM 1083 O O   . PRO A 1 181 ? 10.07700  4.23200   2.84600   1.000 291.51708 ? 181 PRO F O   1 
ATOM 1084 C CB  . PRO A 1 181 ? 13.08400  4.19800   3.74400   1.000 296.11336 ? 181 PRO F CB  1 
ATOM 1085 C CG  . PRO A 1 181 ? 14.20600  4.59200   2.79700   1.000 292.83435 ? 181 PRO F CG  1 
ATOM 1086 C CD  . PRO A 1 181 ? 14.52300  3.33800   2.04300   1.000 275.43929 ? 181 PRO F CD  1 
ATOM 1087 N N   . ASP A 1 182 ? 11.17900  4.01500   0.87800   1.000 292.61640 ? 182 ASP F N   1 
ATOM 1088 C CA  . ASP A 1 182 ? 10.13600  4.66900   0.09500   1.000 285.85793 ? 182 ASP F CA  1 
ATOM 1089 C C   . ASP A 1 182 ? 9.13200   3.56100   -0.17100  1.000 275.62948 ? 182 ASP F C   1 
ATOM 1090 O O   . ASP A 1 182 ? 9.28400   2.73700   -1.08600  1.000 272.46718 ? 182 ASP F O   1 
ATOM 1091 C CB  . ASP A 1 182 ? 10.69700  5.31300   -1.16600  1.000 284.46457 ? 182 ASP F CB  1 
ATOM 1092 C CG  . ASP A 1 182 ? 9.68800   6.18500   -1.87800  1.000 276.06462 ? 182 ASP F CG  1 
ATOM 1093 O OD1 . ASP A 1 182 ? 8.82400   6.75100   -1.17300  1.000 277.13792 ? 182 ASP F OD1 1 
ATOM 1094 O OD2 . ASP A 1 182 ? 9.81000   6.37800   -3.09800  1.000 273.44743 ? 182 ASP F OD2 1 
ATOM 1095 N N   . LEU A 1 183 ? 8.06800   3.59500   0.61600   1.000 267.02071 ? 183 LEU F N   1 
ATOM 1096 C CA  . LEU A 1 183 ? 6.97800   2.67600   0.44000   1.000 258.95869 ? 183 LEU F CA  1 
ATOM 1097 C C   . LEU A 1 183 ? 6.08100   3.11400   -0.70200  1.000 257.78477 ? 183 LEU F C   1 
ATOM 1098 O O   . LEU A 1 183 ? 5.50600   2.25500   -1.38200  1.000 259.51748 ? 183 LEU F O   1 
ATOM 1099 C CB  . LEU A 1 183 ? 6.21900   2.61900   1.77200   1.000 247.35197 ? 183 LEU F CB  1 
ATOM 1100 C CG  . LEU A 1 183 ? 7.02400   2.27200   3.03700   1.000 244.86125 ? 183 LEU F CG  1 
ATOM 1101 C CD1 . LEU A 1 183 ? 6.11000   1.84700   4.15600   1.000 243.14886 ? 183 LEU F CD1 1 
ATOM 1102 C CD2 . LEU A 1 183 ? 8.07600   1.21000   2.78800   1.000 246.85291 ? 183 LEU F CD2 1 
ATOM 1103 N N   . LYS A 1 184 ? 6.08000   4.41400   -1.02000  1.000 256.91464 ? 184 LYS F N   1 
ATOM 1104 C CA  . LYS A 1 184 ? 5.39200   4.94600   -2.20200  1.000 261.21495 ? 184 LYS F CA  1 
ATOM 1105 C C   . LYS A 1 184 ? 5.79300   4.24500   -3.49900  1.000 261.01074 ? 184 LYS F C   1 
ATOM 1106 O O   . LYS A 1 184 ? 4.95600   4.02000   -4.38900  1.000 262.79815 ? 184 LYS F O   1 
ATOM 1107 C CB  . LYS A 1 184 ? 5.64200   6.45800   -2.32900  1.000 265.28538 ? 184 LYS F CB  1 
ATOM 1108 C CG  . LYS A 1 184 ? 5.09900   7.07300   -3.63900  1.000 271.76359 ? 184 LYS F CG  1 
ATOM 1109 C CD  . LYS A 1 184 ? 5.63800   8.48900   -3.91700  1.000 280.27610 ? 184 LYS F CD  1 
ATOM 1110 C CE  . LYS A 1 184 ? 7.13300   8.57500   -4.21400  1.000 280.97022 ? 184 LYS F CE  1 
ATOM 1111 N NZ  . LYS A 1 184 ? 7.52600   10.02300  -4.31600  1.000 298.37594 ? 184 LYS F NZ  1 
ATOM 1112 N N   . MET A 1 185 ? 7.06000   3.85600   -3.60500  1.000 258.94743 ? 185 MET F N   1 
ATOM 1113 C CA  . MET A 1 185 ? 7.55600   3.21300   -4.81400  1.000 261.62960 ? 185 MET F CA  1 
ATOM 1114 C C   . MET A 1 185 ? 6.85800   1.85200   -5.00800  1.000 258.59862 ? 185 MET F C   1 
ATOM 1115 O O   . MET A 1 185 ? 6.40300   1.52700   -6.11600  1.000 264.65853 ? 185 MET F O   1 
ATOM 1116 C CB  . MET A 1 185 ? 9.08800   3.13900   -4.67600  1.000 263.03058 ? 185 MET F CB  1 
ATOM 1117 C CG  . MET A 1 185 ? 10.02500  3.07000   -5.94200  1.000 270.51369 ? 185 MET F CG  1 
ATOM 1118 S SD  . MET A 1 185 ? 10.17300  4.45600   -7.17700  1.000 282.74706 ? 185 MET F SD  1 
ATOM 1119 C CE  . MET A 1 185 ? 10.32100  5.98500   -6.23100  1.000 268.53786 ? 185 MET F CE  1 
ATOM 1120 N N   . ALA A 1 186 ? 6.69100   1.07800   -3.92900  1.000 252.70011 ? 186 ALA F N   1 
ATOM 1121 C CA  . ALA A 1 186 ? 6.00800   -0.21700  -4.01900  1.000 250.60259 ? 186 ALA F CA  1 
ATOM 1122 C C   . ALA A 1 186 ? 4.52700   -0.08100  -4.40600  1.000 253.26653 ? 186 ALA F C   1 
ATOM 1123 O O   . ALA A 1 186 ? 4.00300   -0.89600  -5.18600  1.000 256.22412 ? 186 ALA F O   1 
ATOM 1124 C CB  . ALA A 1 186 ? 6.12900   -0.96700  -2.69600  1.000 242.73309 ? 186 ALA F CB  1 
ATOM 1125 N N   . VAL A 1 187 ? 3.82100   0.91400   -3.85700  1.000 250.68523 ? 187 VAL F N   1 
ATOM 1126 C CA  . VAL A 1 187 ? 2.40100   1.06500   -4.17800  1.000 247.54902 ? 187 VAL F CA  1 
ATOM 1127 C C   . VAL A 1 187 ? 2.17000   1.55900   -5.60200  1.000 249.41729 ? 187 VAL F C   1 
ATOM 1128 O O   . VAL A 1 187 ? 1.27200   1.05800   -6.30700  1.000 248.95660 ? 187 VAL F O   1 
ATOM 1129 C CB  . VAL A 1 187 ? 1.76000   2.02500   -3.16300  1.000 243.54443 ? 187 VAL F CB  1 
ATOM 1130 C CG1 . VAL A 1 187 ? 0.31600   2.31400   -3.50800  1.000 244.88527 ? 187 VAL F CG1 1 
ATOM 1131 C CG2 . VAL A 1 187 ? 1.82600   1.42000   -1.79600  1.000 241.99641 ? 187 VAL F CG2 1 
ATOM 1132 N N   . SER A 1 188 ? 3.01500   2.46400   -6.09600  1.000 250.75475 ? 188 SER F N   1 
ATOM 1133 C CA  . SER A 1 188 ? 2.86000   2.82500   -7.49900  1.000 248.98436 ? 188 SER F CA  1 
ATOM 1134 C C   . SER A 1 188 ? 3.09400   1.61000   -8.38500  1.000 253.67407 ? 188 SER F C   1 
ATOM 1135 O O   . SER A 1 188 ? 2.35900   1.38900   -9.35200  1.000 254.00680 ? 188 SER F O   1 
ATOM 1136 C CB  . SER A 1 188 ? 3.75800   4.00500   -7.87300  1.000 259.42821 ? 188 SER F CB  1 
ATOM 1137 O OG  . SER A 1 188 ? 5.07100   3.85000   -7.39600  1.000 274.71046 ? 188 SER F OG  1 
ATOM 1138 N N   . PHE A 1 189 ? 4.10000   0.79300   -8.04800  1.000 258.44905 ? 189 PHE F N   1 
ATOM 1139 C CA  . PHE A 1 189 ? 4.37300   -0.42100  -8.81900  1.000 257.25057 ? 189 PHE F CA  1 
ATOM 1140 C C   . PHE A 1 189 ? 3.19300   -1.40500  -8.89700  1.000 258.47231 ? 189 PHE F C   1 
ATOM 1141 O O   . PHE A 1 189 ? 2.83900   -1.86300  -9.99500  1.000 259.62625 ? 189 PHE F O   1 
ATOM 1142 C CB  . PHE A 1 189 ? 5.59500   -1.07300  -8.16400  1.000 251.00837 ? 189 PHE F CB  1 
ATOM 1143 C CG  . PHE A 1 189 ? 6.24500   -2.12900  -8.96200  1.000 239.37080 ? 189 PHE F CG  1 
ATOM 1144 C CD1 . PHE A 1 189 ? 5.88000   -2.38500  -10.26400 1.000 236.69206 ? 189 PHE F CD1 1 
ATOM 1145 C CD2 . PHE A 1 189 ? 7.19700   -2.92300  -8.35800  1.000 235.25789 ? 189 PHE F CD2 1 
ATOM 1146 C CE1 . PHE A 1 189 ? 6.45700   -3.41100  -10.94000 1.000 237.36483 ? 189 PHE F CE1 1 
ATOM 1147 C CE2 . PHE A 1 189 ? 7.78900   -3.93600  -9.02900  1.000 235.05344 ? 189 PHE F CE2 1 
ATOM 1148 C CZ  . PHE A 1 189 ? 7.42000   -4.18900  -10.32600 1.000 238.73574 ? 189 PHE F CZ  1 
ATOM 1149 N N   . SER A 1 190 ? 2.57100   -1.76100  -7.75800  1.000 257.41835 ? 190 SER F N   1 
ATOM 1150 C CA  . SER A 1 190 ? 1.44000   -2.71100  -7.83500  1.000 252.28254 ? 190 SER F CA  1 
ATOM 1151 C C   . SER A 1 190 ? 0.19700   -2.13600  -8.51400  1.000 253.16935 ? 190 SER F C   1 
ATOM 1152 O O   . SER A 1 190 ? -0.49500  -2.85800  -9.25300  1.000 254.17635 ? 190 SER F O   1 
ATOM 1153 C CB  . SER A 1 190 ? 1.01700   -3.21400  -6.46800  1.000 245.98790 ? 190 SER F CB  1 
ATOM 1154 O OG  . SER A 1 190 ? 0.32100   -2.18900  -5.81400  1.000 249.04058 ? 190 SER F OG  1 
ATOM 1155 N N   . GLN A 1 191 ? 0.02300   -0.81000  -8.45900  1.000 253.43174 ? 191 GLN F N   1 
ATOM 1156 C CA  . GLN A 1 191 ? -1.10400  -0.19100  -9.14900  1.000 251.69074 ? 191 GLN F CA  1 
ATOM 1157 C C   . GLN A 1 191 ? -0.89400  -0.15900  -10.64600 1.000 255.54199 ? 191 GLN F C   1 
ATOM 1158 O O   . GLN A 1 191 ? -1.85300  -0.31100  -11.41900 1.000 250.04782 ? 191 GLN F O   1 
ATOM 1159 C CB  . GLN A 1 191 ? -1.20200  1.24200   -8.67500  1.000 252.11899 ? 191 GLN F CB  1 
ATOM 1160 C CG  . GLN A 1 191 ? -1.63100  1.42400   -7.28000  1.000 258.74601 ? 191 GLN F CG  1 
ATOM 1161 C CD  . GLN A 1 191 ? -1.72900  2.88500   -6.96900  1.000 263.89886 ? 191 GLN F CD  1 
ATOM 1162 O OE1 . GLN A 1 191 ? -1.09900  3.69400   -7.64500  1.000 259.71214 ? 191 GLN F OE1 1 
ATOM 1163 N NE2 . GLN A 1 191 ? -2.48000  3.24100   -5.93200  1.000 271.75845 ? 191 GLN F NE2 1 
ATOM 1164 N N   . PHE A 1 192 ? 0.34600   0.11100   -11.06700 1.000 263.69337 ? 192 PHE F N   1 
ATOM 1165 C CA  . PHE A 1 192 ? 0.62000   0.29700   -12.48100 1.000 268.33078 ? 192 PHE F CA  1 
ATOM 1166 C C   . PHE A 1 192 ? 0.73200   -1.04800  -13.19200 1.000 257.53643 ? 192 PHE F C   1 
ATOM 1167 O O   . PHE A 1 192 ? 0.31100   -1.18400  -14.35300 1.000 248.34153 ? 192 PHE F O   1 
ATOM 1168 C CB  . PHE A 1 192 ? 1.88900   1.15100   -12.59300 1.000 277.22154 ? 192 PHE F CB  1 
ATOM 1169 C CG  . PHE A 1 192 ? 1.60100   2.63400   -12.55100 1.000 287.47038 ? 192 PHE F CG  1 
ATOM 1170 C CD1 . PHE A 1 192 ? 1.23600   3.33700   -13.68700 1.000 299.47217 ? 192 PHE F CD1 1 
ATOM 1171 C CD2 . PHE A 1 192 ? 1.61500   3.30600   -11.32600 1.000 276.66737 ? 192 PHE F CD2 1 
ATOM 1172 C CE1 . PHE A 1 192 ? 0.92800   4.69500   -13.60400 1.000 304.05049 ? 192 PHE F CE1 1 
ATOM 1173 C CE2 . PHE A 1 192 ? 1.31400   4.65100   -11.23200 1.000 286.96542 ? 192 PHE F CE2 1 
ATOM 1174 C CZ  . PHE A 1 192 ? 0.96800   5.35100   -12.37200 1.000 304.52369 ? 192 PHE F CZ  1 
ATOM 1175 N N   . ASN A 1 193 ? 1.14500   -2.08900  -12.47800 1.000 253.27822 ? 193 ASN F N   1 
ATOM 1176 C CA  . ASN A 1 193 ? 1.23100   -3.33200  -13.19900 1.000 240.46195 ? 193 ASN F CA  1 
ATOM 1177 C C   . ASN A 1 193 ? -0.07100  -4.07900  -13.02800 1.000 241.07832 ? 193 ASN F C   1 
ATOM 1178 O O   . ASN A 1 193 ? -0.22000  -5.12900  -13.63900 1.000 236.25889 ? 193 ASN F O   1 
ATOM 1179 C CB  . ASN A 1 193 ? 2.49300   -4.14800  -12.82500 1.000 235.33635 ? 193 ASN F CB  1 
ATOM 1180 C CG  . ASN A 1 193 ? 2.46500   -4.74900  -11.42500 1.000 238.99343 ? 193 ASN F CG  1 
ATOM 1181 O OD1 . ASN A 1 193 ? 1.49200   -5.37100  -11.00100 1.000 243.36731 ? 193 ASN F OD1 1 
ATOM 1182 N ND2 . ASN A 1 193 ? 3.57700   -4.59400  -10.71200 1.000 236.80444 ? 193 ASN F ND2 1 
ATOM 1183 N N   . ARG A 1 194 ? -1.00900  -3.54600  -12.20800 1.000 249.59822 ? 194 ARG F N   1 
ATOM 1184 C CA  . ARG A 1 194 ? -2.28800  -4.22400  -12.00900 1.000 252.74549 ? 194 ARG F CA  1 
ATOM 1185 C C   . ARG A 1 194 ? -2.96400  -4.36100  -13.36000 1.000 247.65531 ? 194 ARG F C   1 
ATOM 1186 O O   . ARG A 1 194 ? -3.59100  -5.38800  -13.64600 1.000 244.90468 ? 194 ARG F O   1 
ATOM 1187 C CB  . ARG A 1 194 ? -3.20900  -3.52500  -10.98500 1.000 256.49958 ? 194 ARG F CB  1 
ATOM 1188 C CG  . ARG A 1 194 ? -4.67900  -4.13500  -10.87600 1.000 249.02249 ? 194 ARG F CG  1 
ATOM 1189 C CD  . ARG A 1 194 ? -4.78200  -5.68100  -10.66900 1.000 232.59845 ? 194 ARG F CD  1 
ATOM 1190 N NE  . ARG A 1 194 ? -3.77400  -6.24000  -9.77800  1.000 233.56355 ? 194 ARG F NE  1 
ATOM 1191 C CZ  . ARG A 1 194 ? -3.93400  -6.42700  -8.47700  1.000 236.78025 ? 194 ARG F CZ  1 
ATOM 1192 N NH1 . ARG A 1 194 ? -5.06300  -6.10500  -7.86600  1.000 243.70320 ? 194 ARG F NH1 1 
ATOM 1193 N NH2 . ARG A 1 194 ? -2.91500  -6.89000  -7.76000  1.000 235.71681 ? 194 ARG F NH2 1 
ATOM 1194 N N   . ARG A 1 195 ? -2.89100  -3.31700  -14.19600 1.000 244.58211 ? 195 ARG F N   1 
ATOM 1195 C CA  . ARG A 1 195 ? -3.58300  -3.44400  -15.46400 1.000 240.68475 ? 195 ARG F CA  1 
ATOM 1196 C C   . ARG A 1 195 ? -2.92000  -4.56500  -16.24100 1.000 229.23477 ? 195 ARG F C   1 
ATOM 1197 O O   . ARG A 1 195 ? -3.59900  -5.42000  -16.80900 1.000 222.77123 ? 195 ARG F O   1 
ATOM 1198 C CB  . ARG A 1 195 ? -3.58700  -2.13500  -16.25500 1.000 240.16684 ? 195 ARG F CB  1 
ATOM 1199 C CG  . ARG A 1 195 ? -4.50600  -2.25200  -17.49900 1.000 235.67287 ? 195 ARG F CG  1 
ATOM 1200 C CD  . ARG A 1 195 ? -4.42200  -1.09600  -18.50700 1.000 235.01296 ? 195 ARG F CD  1 
ATOM 1201 N NE  . ARG A 1 195 ? -5.22700  -1.35900  -19.70400 1.000 225.89481 ? 195 ARG F NE  1 
ATOM 1202 C CZ  . ARG A 1 195 ? -5.51500  -0.46200  -20.64500 1.000 216.89594 ? 195 ARG F CZ  1 
ATOM 1203 N NH1 . ARG A 1 195 ? -5.08000  0.79000   -20.57100 1.000 224.92295 ? 195 ARG F NH1 1 
ATOM 1204 N NH2 . ARG A 1 195 ? -6.26400  -0.82800  -21.68700 1.000 214.76673 ? 195 ARG F NH2 1 
ATOM 1205 N N   . PHE A 1 196 ? -1.60000  -4.62400  -16.21900 1.000 224.58497 ? 196 PHE F N   1 
ATOM 1206 C CA  . PHE A 1 196 ? -0.96200  -5.70700  -16.94300 1.000 225.54188 ? 196 PHE F CA  1 
ATOM 1207 C C   . PHE A 1 196 ? -1.26000  -7.08400  -16.34300 1.000 227.94646 ? 196 PHE F C   1 
ATOM 1208 O O   . PHE A 1 196 ? -1.51500  -8.02100  -17.09800 1.000 221.77895 ? 196 PHE F O   1 
ATOM 1209 C CB  . PHE A 1 196 ? 0.54300   -5.47500  -16.96400 1.000 233.93722 ? 196 PHE F CB  1 
ATOM 1210 C CG  . PHE A 1 196 ? 1.34800   -6.72100  -17.24500 1.000 243.99886 ? 196 PHE F CG  1 
ATOM 1211 C CD1 . PHE A 1 196 ? 1.37300   -7.29400  -18.51100 1.000 242.74288 ? 196 PHE F CD1 1 
ATOM 1212 C CD2 . PHE A 1 196 ? 2.12600   -7.29600  -16.24000 1.000 246.62347 ? 196 PHE F CD2 1 
ATOM 1213 C CE1 . PHE A 1 196 ? 2.13800   -8.43900  -18.76400 1.000 240.73398 ? 196 PHE F CE1 1 
ATOM 1214 C CE2 . PHE A 1 196 ? 2.89400   -8.44300  -16.48300 1.000 243.00652 ? 196 PHE F CE2 1 
ATOM 1215 C CZ  . PHE A 1 196 ? 2.89800   -9.01200  -17.74900 1.000 240.66007 ? 196 PHE F CZ  1 
ATOM 1216 N N   . LEU A 1 197 ? -1.28100  -7.22000  -14.99600 1.000 234.86588 ? 197 LEU F N   1 
ATOM 1217 C CA  . LEU A 1 197 ? -1.58800  -8.50700  -14.34200 1.000 234.84086 ? 197 LEU F CA  1 
ATOM 1218 C C   . LEU A 1 197 ? -2.99900  -8.98400  -14.59500 1.000 226.47343 ? 197 LEU F C   1 
ATOM 1219 O O   . LEU A 1 197 ? -3.22700  -10.18300 -14.75000 1.000 226.05032 ? 197 LEU F O   1 
ATOM 1220 C CB  . LEU A 1 197 ? -1.38300  -8.44900  -12.83000 1.000 237.91811 ? 197 LEU F CB  1 
ATOM 1221 C CG  . LEU A 1 197 ? -0.03100  -8.23200  -12.19300 1.000 236.74634 ? 197 LEU F CG  1 
ATOM 1222 C CD1 . LEU A 1 197 ? -0.23300  -8.20600  -10.70600 1.000 239.40977 ? 197 LEU F CD1 1 
ATOM 1223 C CD2 . LEU A 1 197 ? 0.86100   -9.38000  -12.56500 1.000 234.96207 ? 197 LEU F CD2 1 
ATOM 1224 N N   . ASN A 1 198 ? -3.97800  -8.09300  -14.51900 1.000 224.14943 ? 198 ASN F N   1 
ATOM 1225 C CA  . ASN A 1 198 ? -5.32100  -8.54200  -14.82600 1.000 216.57013 ? 198 ASN F CA  1 
ATOM 1226 C C   . ASN A 1 198 ? -5.35600  -8.84900  -16.31600 1.000 216.57648 ? 198 ASN F C   1 
ATOM 1227 O O   . ASN A 1 198 ? -6.04000  -9.76900  -16.73600 1.000 220.11844 ? 198 ASN F O   1 
ATOM 1228 C CB  . ASN A 1 198 ? -6.44000  -7.61200  -14.30500 1.000 213.14074 ? 198 ASN F CB  1 
ATOM 1229 C CG  . ASN A 1 198 ? -6.53300  -7.53900  -12.73900 1.000 212.18062 ? 198 ASN F CG  1 
ATOM 1230 O OD1 . ASN A 1 198 ? -5.95700  -8.35200  -12.00300 1.000 211.50805 ? 198 ASN F OD1 1 
ATOM 1231 N ND2 . ASN A 1 198 ? -7.33300  -6.60000  -12.25600 1.000 212.46766 ? 198 ASN F ND2 1 
ATOM 1232 N N   . VAL A 1 199 ? -4.61500  -8.08900  -17.12800 1.000 211.12093 ? 199 VAL F N   1 
ATOM 1233 C CA  . VAL A 1 199 ? -4.51400  -8.39500  -18.54900 1.000 207.12340 ? 199 VAL F CA  1 
ATOM 1234 C C   . VAL A 1 199 ? -3.94600  -9.79200  -18.73500 1.000 208.46856 ? 199 VAL F C   1 
ATOM 1235 O O   . VAL A 1 199 ? -4.38900  -10.56900 -19.59000 1.000 207.41193 ? 199 VAL F O   1 
ATOM 1236 C CB  . VAL A 1 199 ? -3.63200  -7.33900  -19.22600 1.000 202.11333 ? 199 VAL F CB  1 
ATOM 1237 C CG1 . VAL A 1 199 ? -3.26600  -7.81300  -20.54200 1.000 207.45342 ? 199 VAL F CG1 1 
ATOM 1238 C CG2 . VAL A 1 199 ? -4.40800  -6.06700  -19.42100 1.000 203.30500 ? 199 VAL F CG2 1 
ATOM 1239 N N   . VAL A 1 200 ? -2.98200  -10.14300 -17.90900 1.000 212.66813 ? 200 VAL F N   1 
ATOM 1240 C CA  . VAL A 1 200 ? -2.39300  -11.47000 -17.95900 1.000 219.18471 ? 200 VAL F CA  1 
ATOM 1241 C C   . VAL A 1 200 ? -3.39700  -12.50200 -17.47600 1.000 223.59607 ? 200 VAL F C   1 
ATOM 1242 O O   . VAL A 1 200 ? -3.51300  -13.57300 -18.06700 1.000 223.76163 ? 200 VAL F O   1 
ATOM 1243 C CB  . VAL A 1 200 ? -1.09300  -11.50600 -17.14200 1.000 226.00317 ? 200 VAL F CB  1 
ATOM 1244 C CG1 . VAL A 1 200 ? -0.56300  -12.94100 -16.99300 1.000 223.50515 ? 200 VAL F CG1 1 
ATOM 1245 C CG2 . VAL A 1 200 ? -0.06900  -10.65400 -17.81900 1.000 226.32086 ? 200 VAL F CG2 1 
ATOM 1246 N N   . ARG A 1 201 ? -4.14800  -12.19700 -16.40600 1.000 226.42039 ? 201 ARG F N   1 
ATOM 1247 C CA  . ARG A 1 201 ? -5.18800  -13.12000 -15.94900 1.000 221.64697 ? 201 ARG F CA  1 
ATOM 1248 C C   . ARG A 1 201 ? -6.15600  -13.36200 -17.09200 1.000 223.38679 ? 201 ARG F C   1 
ATOM 1249 O O   . ARG A 1 201 ? -6.56600  -14.49700 -17.34300 1.000 223.13417 ? 201 ARG F O   1 
ATOM 1250 C CB  . ARG A 1 201 ? -5.96300  -12.62300 -14.71200 1.000 211.62577 ? 201 ARG F CB  1 
ATOM 1251 C CG  . ARG A 1 201 ? -5.35100  -12.80400 -13.32100 1.000 205.01109 ? 201 ARG F CG  1 
ATOM 1252 C CD  . ARG A 1 201 ? -6.20600  -12.07700 -12.28400 1.000 210.53819 ? 201 ARG F CD  1 
ATOM 1253 N NE  . ARG A 1 201 ? -5.43900  -11.70500 -11.10000 1.000 229.01971 ? 201 ARG F NE  1 
ATOM 1254 C CZ  . ARG A 1 201 ? -5.91400  -10.97400 -10.10000 1.000 234.39225 ? 201 ARG F CZ  1 
ATOM 1255 N NH1 . ARG A 1 201 ? -7.15300  -10.51500 -10.11100 1.000 239.54964 ? 201 ARG F NH1 1 
ATOM 1256 N NH2 . ARG A 1 201 ? -5.12300  -10.68000 -9.07200  1.000 236.84432 ? 201 ARG F NH2 1 
ATOM 1257 N N   . GLN A 1 202 ? -6.56700  -12.28500 -17.77300 1.000 226.33579 ? 202 GLN F N   1 
ATOM 1258 C CA  . GLN A 1 202 ? -7.58800  -12.39900 -18.80800 1.000 222.25430 ? 202 GLN F CA  1 
ATOM 1259 C C   . GLN A 1 202 ? -7.04600  -13.18500 -20.00200 1.000 209.69721 ? 202 GLN F C   1 
ATOM 1260 O O   . GLN A 1 202 ? -7.82400  -13.79800 -20.73800 1.000 204.85659 ? 202 GLN F O   1 
ATOM 1261 C CB  . GLN A 1 202 ? -8.13500  -10.98800 -19.16300 1.000 227.26058 ? 202 GLN F CB  1 
ATOM 1262 C CG  . GLN A 1 202 ? -8.95200  -10.29100 -17.95000 1.000 240.35674 ? 202 GLN F CG  1 
ATOM 1263 C CD  . GLN A 1 202 ? -9.22900  -8.73500  -18.03600 1.000 234.98304 ? 202 GLN F CD  1 
ATOM 1264 O OE1 . GLN A 1 202 ? -9.13500  -8.11600  -19.10600 1.000 226.62966 ? 202 GLN F OE1 1 
ATOM 1265 N NE2 . GLN A 1 202 ? -9.59800  -8.12900  -16.88400 1.000 237.45528 ? 202 GLN F NE2 1 
ATOM 1266 N N   . PHE A 1 203 ? -5.75400  -13.08300 -20.29100 1.000 203.47770 ? 203 PHE F N   1 
ATOM 1267 C CA  . PHE A 1 203 ? -5.22700  -13.89500 -21.37900 1.000 195.64764 ? 203 PHE F CA  1 
ATOM 1268 C C   . PHE A 1 203 ? -4.81900  -15.30200 -20.99700 1.000 200.80926 ? 203 PHE F C   1 
ATOM 1269 O O   . PHE A 1 203 ? -4.80700  -16.18100 -21.85700 1.000 201.38388 ? 203 PHE F O   1 
ATOM 1270 C CB  . PHE A 1 203 ? -4.13500  -13.16400 -22.07600 1.000 191.77737 ? 203 PHE F CB  1 
ATOM 1271 C CG  . PHE A 1 203 ? -4.67300  -12.29200 -23.08500 1.000 193.64479 ? 203 PHE F CG  1 
ATOM 1272 C CD1 . PHE A 1 203 ? -5.56900  -12.83000 -23.97500 1.000 198.46780 ? 203 PHE F CD1 1 
ATOM 1273 C CD2 . PHE A 1 203 ? -4.44200  -10.95200 -23.10400 1.000 204.54337 ? 203 PHE F CD2 1 
ATOM 1274 C CE1 . PHE A 1 203 ? -6.13200  -12.07200 -24.96500 1.000 202.07933 ? 203 PHE F CE1 1 
ATOM 1275 C CE2 . PHE A 1 203 ? -5.02200  -10.16100 -24.10500 1.000 201.20376 ? 203 PHE F CE2 1 
ATOM 1276 C CZ  . PHE A 1 203 ? -5.86700  -10.72900 -25.03000 1.000 197.00519 ? 203 PHE F CZ  1 
ATOM 1277 N N   . SER A 1 204 ? -4.32100  -15.50500 -19.79400 1.000 206.64375 ? 204 SER F N   1 
ATOM 1278 C CA  . SER A 1 204 ? -3.91400  -16.84100 -19.38100 1.000 212.65911 ? 204 SER F CA  1 
ATOM 1279 C C   . SER A 1 204 ? -5.11300  -17.73200 -19.07100 1.000 218.36066 ? 204 SER F C   1 
ATOM 1280 O O   . SER A 1 204 ? -5.12100  -18.92300 -19.42700 1.000 217.77940 ? 204 SER F O   1 
ATOM 1281 C CB  . SER A 1 204 ? -3.01600  -16.73100 -18.15200 1.000 219.39860 ? 204 SER F CB  1 
ATOM 1282 O OG  . SER A 1 204 ? -1.86000  -15.96200 -18.44600 1.000 224.78185 ? 204 SER F OG  1 
ATOM 1283 N N   . ASP A 1 205 ? -6.16300  -17.13500 -18.46700 1.000 221.93690 ? 205 ASP F N   1 
ATOM 1284 C CA  . ASP A 1 205 ? -7.36700  -17.86000 -18.05200 1.000 222.91888 ? 205 ASP F CA  1 
ATOM 1285 C C   . ASP A 1 205 ? -8.23300  -18.30800 -19.24500 1.000 220.19512 ? 205 ASP F C   1 
ATOM 1286 O O   . ASP A 1 205 ? -8.90000  -19.34700 -19.15800 1.000 217.47378 ? 205 ASP F O   1 
ATOM 1287 C CB  . ASP A 1 205 ? -8.22100  -16.99600 -17.06600 1.000 217.44773 ? 205 ASP F CB  1 
ATOM 1288 C CG  . ASP A 1 205 ? -7.53900  -16.71900 -15.65400 1.000 206.98615 ? 205 ASP F CG  1 
ATOM 1289 O OD1 . ASP A 1 205 ? -6.47900  -17.27600 -15.31900 1.000 211.27771 ? 205 ASP F OD1 1 
ATOM 1290 O OD2 . ASP A 1 205 ? -8.08300  -15.91100 -14.85800 1.000 192.70592 ? 205 ASP F OD2 1 
ATOM 1291 N N   . ASN A 1 206 ? -8.20800  -17.59900 -20.38200 1.000 220.26324 ? 206 ASN F N   1 
ATOM 1292 C CA  . ASN A 1 206 ? -9.11500  -17.92600 -21.48500 1.000 220.42959 ? 206 ASN F CA  1 
ATOM 1293 C C   . ASN A 1 206 ? -8.43100  -18.56300 -22.69500 1.000 216.36385 ? 206 ASN F C   1 
ATOM 1294 O O   . ASN A 1 206 ? -9.05900  -18.66700 -23.75800 1.000 215.27077 ? 206 ASN F O   1 
ATOM 1295 C CB  . ASN A 1 206 ? -9.80200  -16.63200 -21.94300 1.000 217.28843 ? 206 ASN F CB  1 
ATOM 1296 C CG  . ASN A 1 206 ? -10.67200 -16.00300 -20.86000 1.000 218.57242 ? 206 ASN F CG  1 
ATOM 1297 O OD1 . ASN A 1 206 ? -10.72200 -14.77000 -20.72800 1.000 208.11970 ? 206 ASN F OD1 1 
ATOM 1298 N ND2 . ASN A 1 206 ? -11.34900 -16.83600 -20.07800 1.000 227.33190 ? 206 ASN F ND2 1 
ATOM 1299 N N   . ALA A 1 207 ? -7.19400  -19.04200 -22.53800 1.000 212.96354 ? 207 ALA F N   1 
ATOM 1300 C CA  . ALA A 1 207 ? -6.42000  -19.72900 -23.58100 1.000 212.34204 ? 207 ALA F CA  1 
ATOM 1301 C C   . ALA A 1 207 ? -6.31300  -18.89200 -24.86900 1.000 216.21351 ? 207 ALA F C   1 
ATOM 1302 O O   . ALA A 1 207 ? -6.28000  -19.41800 -25.98600 1.000 211.80438 ? 207 ALA F O   1 
ATOM 1303 C CB  . ALA A 1 207 ? -7.00200  -21.11300 -23.86300 1.000 211.41485 ? 207 ALA F CB  1 
ATOM 1304 N N   . GLY A 1 208 ? -6.18800  -17.56800 -24.69000 1.000 219.53298 ? 208 GLY F N   1 
ATOM 1305 C CA  . GLY A 1 208 ? -5.84900  -16.56000 -25.69900 1.000 212.97029 ? 208 GLY F CA  1 
ATOM 1306 C C   . GLY A 1 208 ? -6.94300  -15.80500 -26.45800 1.000 204.42712 ? 208 GLY F C   1 
ATOM 1307 O O   . GLY A 1 208 ? -6.59800  -14.87900 -27.20800 1.000 204.20400 ? 208 GLY F O   1 
ATOM 1308 N N   . ILE A 1 209 ? -8.22600  -16.16700 -26.37300 1.000 197.54388 ? 209 ILE F N   1 
ATOM 1309 C CA  . ILE A 1 209 ? -9.26300  -15.42000 -27.10100 1.000 187.20548 ? 209 ILE F CA  1 
ATOM 1310 C C   . ILE A 1 209 ? -10.43500 -15.09100 -26.19200 1.000 186.94040 ? 209 ILE F C   1 
ATOM 1311 O O   . ILE A 1 209 ? -11.31700 -15.93200 -25.98600 1.000 182.61921 ? 209 ILE F O   1 
ATOM 1312 C CB  . ILE A 1 209 ? -9.73000  -16.12300 -28.36500 1.000 179.63647 ? 209 ILE F CB  1 
ATOM 1313 C CG1 . ILE A 1 209 ? -8.49400  -16.46800 -29.19100 1.000 186.35819 ? 209 ILE F CG1 1 
ATOM 1314 C CG2 . ILE A 1 209 ? -10.73900 -15.26200 -29.09000 1.000 178.16801 ? 209 ILE F CG2 1 
ATOM 1315 C CD1 . ILE A 1 209 ? -8.77300  -17.22000 -30.41300 1.000 207.45817 ? 209 ILE F CD1 1 
ATOM 1316 N N   . THR A 1 210 ? -10.46700 -13.88500 -25.64800 1.000 192.22213 ? 210 THR F N   1 
ATOM 1317 C CA  . THR A 1 210 ? -11.60900 -13.57500 -24.82100 1.000 197.82998 ? 210 THR F CA  1 
ATOM 1318 C C   . THR A 1 210 ? -12.81900 -13.46200 -25.73900 1.000 206.66721 ? 210 THR F C   1 
ATOM 1319 O O   . THR A 1 210 ? -12.66100 -13.15600 -26.92100 1.000 204.94794 ? 210 THR F O   1 
ATOM 1320 C CB  . THR A 1 210 ? -11.44100 -12.26700 -24.02600 1.000 198.25224 ? 210 THR F CB  1 
ATOM 1321 O OG1 . THR A 1 210 ? -11.49400 -11.12000 -24.88800 1.000 203.40118 ? 210 THR F OG1 1 
ATOM 1322 C CG2 . THR A 1 210 ? -10.17500 -12.25700 -23.21300 1.000 198.48239 ? 210 THR F CG2 1 
ATOM 1323 N N   . PRO A 1 211 ? -14.01100 -13.83300 -25.25800 1.000 218.58012 ? 211 PRO F N   1 
ATOM 1324 C CA  . PRO A 1 211 ? -15.23800 -13.65000 -26.06600 1.000 225.26715 ? 211 PRO F CA  1 
ATOM 1325 C C   . PRO A 1 211 ? -15.71600 -12.15600 -26.16600 1.000 223.25197 ? 211 PRO F C   1 
ATOM 1326 O O   . PRO A 1 211 ? -16.56700 -11.87000 -27.03000 1.000 217.77133 ? 211 PRO F O   1 
ATOM 1327 C CB  . PRO A 1 211 ? -16.22200 -14.67700 -25.46400 1.000 222.26966 ? 211 PRO F CB  1 
ATOM 1328 C CG  . PRO A 1 211 ? -15.81700 -14.84900 -24.08500 1.000 220.07505 ? 211 PRO F CG  1 
ATOM 1329 C CD  . PRO A 1 211 ? -14.27100 -14.70200 -24.08800 1.000 214.61720 ? 211 PRO F CD  1 
ATOM 1330 N N   . ALA A 1 212 ? -15.28800 -11.25100 -25.25600 1.000 220.76107 ? 212 ALA F N   1 
ATOM 1331 C CA  . ALA A 1 212 ? -15.63000 -9.80500  -25.30200 1.000 206.21704 ? 212 ALA F CA  1 
ATOM 1332 C C   . ALA A 1 212 ? -14.45500 -8.94200  -24.78600 1.000 199.45849 ? 212 ALA F C   1 
ATOM 1333 O O   . ALA A 1 212 ? -13.36600 -9.44600  -24.47800 1.000 196.40969 ? 212 ALA F O   1 
ATOM 1334 C CB  . ALA A 1 212 ? -16.92900 -9.50200  -24.54400 1.000 203.35456 ? 212 ALA F CB  1 
ATOM 1335 N N   . ILE A 1 213 ? -14.70900 -7.62800  -24.69600 1.000 197.94368 ? 213 ILE F N   1 
ATOM 1336 C CA  . ILE A 1 213 ? -13.76200 -6.57500  -24.29600 1.000 203.17727 ? 213 ILE F CA  1 
ATOM 1337 C C   . ILE A 1 213 ? -13.96300 -6.08300  -22.87100 1.000 201.32332 ? 213 ILE F C   1 
ATOM 1338 O O   . ILE A 1 213 ? -14.86100 -5.26400  -22.63400 1.000 206.07450 ? 213 ILE F O   1 
ATOM 1339 C CB  . ILE A 1 213 ? -13.89700 -5.36300  -25.22100 1.000 209.40367 ? 213 ILE F CB  1 
ATOM 1340 C CG1 . ILE A 1 213 ? -13.77400 -5.79400  -26.66200 1.000 208.24485 ? 213 ILE F CG1 1 
ATOM 1341 C CG2 . ILE A 1 213 ? -12.82300 -4.30400  -24.88900 1.000 212.72276 ? 213 ILE F CG2 1 
ATOM 1342 C CD1 . ILE A 1 213 ? -14.19500 -4.73700  -27.60300 1.000 205.31132 ? 213 ILE F CD1 1 
ATOM 1343 N N   . SER A 1 214 ? -13.10900 -6.47700  -21.92500 1.000 194.44157 ? 214 SER F N   1 
ATOM 1344 C CA  . SER A 1 214 ? -13.39400 -5.91700  -20.61000 1.000 201.89876 ? 214 SER F CA  1 
ATOM 1345 C C   . SER A 1 214 ? -12.93000 -4.45500  -20.58400 1.000 209.55345 ? 214 SER F C   1 
ATOM 1346 O O   . SER A 1 214 ? -12.29000 -3.96800  -21.52100 1.000 206.32521 ? 214 SER F O   1 
ATOM 1347 C CB  . SER A 1 214 ? -12.71900 -6.71500  -19.49200 1.000 202.12095 ? 214 SER F CB  1 
ATOM 1348 O OG  . SER A 1 214 ? -11.35600 -6.36500  -19.34200 1.000 205.22768 ? 214 SER F OG  1 
ATOM 1349 N N   . LEU A 1 215 ? -13.27300 -3.74300  -19.49800 1.000 220.35386 ? 215 LEU F N   1 
ATOM 1350 C CA  . LEU A 1 215 ? -12.85200 -2.34900  -19.30200 1.000 222.26437 ? 215 LEU F CA  1 
ATOM 1351 C C   . LEU A 1 215 ? -11.37500 -2.26700  -18.96500 1.000 228.79128 ? 215 LEU F C   1 
ATOM 1352 O O   . LEU A 1 215 ? -10.81700 -1.16200  -18.89500 1.000 231.46032 ? 215 LEU F O   1 
ATOM 1353 C CB  . LEU A 1 215 ? -13.68200 -1.64600  -18.19600 1.000 215.73251 ? 215 LEU F CB  1 
ATOM 1354 C CG  . LEU A 1 215 ? -13.39700 -0.16800  -17.80200 1.000 203.14506 ? 215 LEU F CG  1 
ATOM 1355 C CD1 . LEU A 1 215 ? -13.73700 0.71500   -18.99000 1.000 201.05179 ? 215 LEU F CD1 1 
ATOM 1356 C CD2 . LEU A 1 215 ? -14.11600 0.30900   -16.54000 1.000 193.47787 ? 215 LEU F CD2 1 
ATOM 1357 N N   . ASP A 1 216 ? -10.76000 -3.42200  -18.71300 1.000 230.99311 ? 216 ASP F N   1 
ATOM 1358 C CA  . ASP A 1 216 ? -9.34300  -3.60100  -18.44900 1.000 226.36053 ? 216 ASP F CA  1 
ATOM 1359 C C   . ASP A 1 216 ? -8.56600  -3.92200  -19.74700 1.000 213.26838 ? 216 ASP F C   1 
ATOM 1360 O O   . ASP A 1 216 ? -7.36500  -3.63600  -19.84000 1.000 210.98851 ? 216 ASP F O   1 
ATOM 1361 C CB  . ASP A 1 216 ? -9.27300  -4.67900  -17.36200 1.000 226.04411 ? 216 ASP F CB  1 
ATOM 1362 C CG  . ASP A 1 216 ? -8.17500  -4.45600  -16.37400 1.000 225.12548 ? 216 ASP F CG  1 
ATOM 1363 O OD1 . ASP A 1 216 ? -7.93300  -3.28000  -16.01400 1.000 224.94887 ? 216 ASP F OD1 1 
ATOM 1364 O OD2 . ASP A 1 216 ? -7.62300  -5.44500  -15.86700 1.000 225.54864 ? 216 ASP F OD2 1 
ATOM 1365 N N   . LEU A 1 217 ? -9.23500  -4.52300  -20.74600 1.000 204.02897 ? 217 LEU F N   1 
ATOM 1366 C CA  . LEU A 1 217 ? -8.66700  -4.70300  -22.08800 1.000 195.83998 ? 217 LEU F CA  1 
ATOM 1367 C C   . LEU A 1 217 ? -8.59400  -3.40000  -22.87000 1.000 196.68869 ? 217 LEU F C   1 
ATOM 1368 O O   . LEU A 1 217 ? -7.69000  -3.19000  -23.68000 1.000 192.42086 ? 217 LEU F O   1 
ATOM 1369 C CB  . LEU A 1 217 ? -9.55700  -5.67500  -22.85000 1.000 197.97409 ? 217 LEU F CB  1 
ATOM 1370 C CG  . LEU A 1 217 ? -9.41100  -7.10000  -22.37200 1.000 201.74651 ? 217 LEU F CG  1 
ATOM 1371 C CD1 . LEU A 1 217 ? -10.16800 -8.07700  -23.26900 1.000 210.25239 ? 217 LEU F CD1 1 
ATOM 1372 C CD2 . LEU A 1 217 ? -7.90300  -7.37800  -22.41200 1.000 198.70514 ? 217 LEU F CD2 1 
ATOM 1373 N N   . MET A 1 218 ? -9.57100  -2.54200  -22.67300 1.000 202.16146 ? 218 MET F N   1 
ATOM 1374 C CA  . MET A 1 218 ? -9.73600  -1.32600  -23.44800 1.000 199.27082 ? 218 MET F CA  1 
ATOM 1375 C C   . MET A 1 218 ? -10.59900 -0.42200  -22.60800 1.000 199.23386 ? 218 MET F C   1 
ATOM 1376 O O   . MET A 1 218 ? -11.80100 -0.68600  -22.48100 1.000 200.98985 ? 218 MET F O   1 
ATOM 1377 C CB  . MET A 1 218 ? -10.39700 -1.64600  -24.70700 1.000 198.99869 ? 218 MET F CB  1 
ATOM 1378 C CG  . MET A 1 218 ? -10.43400 -0.58900  -25.66500 1.000 197.68295 ? 218 MET F CG  1 
ATOM 1379 S SD  . MET A 1 218 ? -11.06800 -1.69700  -26.89500 1.000 196.01792 ? 218 MET F SD  1 
ATOM 1380 C CE  . MET A 1 218 ? -11.21000 -0.65100  -28.33300 1.000 201.62939 ? 218 MET F CE  1 
ATOM 1381 N N   . THR A 1 219 ? -10.06200 0.70100   -22.16200 1.000 196.94744 ? 219 THR F N   1 
ATOM 1382 C CA  . THR A 1 219 ? -10.96800 1.49800   -21.37900 1.000 200.98540 ? 219 THR F CA  1 
ATOM 1383 C C   . THR A 1 219 ? -11.94300 2.13400   -22.32600 1.000 202.93769 ? 219 THR F C   1 
ATOM 1384 O O   . THR A 1 219 ? -11.84500 2.01400   -23.55000 1.000 198.69268 ? 219 THR F O   1 
ATOM 1385 C CB  . THR A 1 219 ? -10.24700 2.50100   -20.48600 1.000 203.21777 ? 219 THR F CB  1 
ATOM 1386 O OG1 . THR A 1 219 ? -9.60500  3.48900   -21.29000 1.000 209.39565 ? 219 THR F OG1 1 
ATOM 1387 C CG2 . THR A 1 219 ? -9.27800  1.81700   -19.51400 1.000 200.98245 ? 219 THR F CG2 1 
ATOM 1388 N N   . ASP A 1 220 ? -12.89900 2.81500   -21.73400 1.000 210.88326 ? 220 ASP F N   1 
ATOM 1389 C CA  . ASP A 1 220 ? -13.90100 3.48200   -22.53600 1.000 218.40763 ? 220 ASP F CA  1 
ATOM 1390 C C   . ASP A 1 220 ? -13.31200 4.55700   -23.44200 1.000 219.64306 ? 220 ASP F C   1 
ATOM 1391 O O   . ASP A 1 220 ? -13.76300 4.68700   -24.57700 1.000 216.73390 ? 220 ASP F O   1 
ATOM 1392 C CB  . ASP A 1 220 ? -15.02200 4.00000   -21.64900 1.000 227.73047 ? 220 ASP F CB  1 
ATOM 1393 C CG  . ASP A 1 220 ? -16.27000 3.11400   -21.76100 1.000 228.81962 ? 220 ASP F CG  1 
ATOM 1394 O OD1 . ASP A 1 220 ? -16.23100 2.12700   -22.55200 1.000 222.49244 ? 220 ASP F OD1 1 
ATOM 1395 O OD2 . ASP A 1 220 ? -17.28800 3.40700   -21.09000 1.000 234.78833 ? 220 ASP F OD2 1 
ATOM 1396 N N   . ALA A 1 221 ? -12.34200 5.36200   -22.98400 1.000 224.40640 ? 221 ALA F N   1 
ATOM 1397 C CA  . ALA A 1 221 ? -11.82300 6.36800   -23.92000 1.000 222.30806 ? 221 ALA F CA  1 
ATOM 1398 C C   . ALA A 1 221 ? -11.09400 5.68500   -25.07900 1.000 216.75097 ? 221 ALA F C   1 
ATOM 1399 O O   . ALA A 1 221 ? -11.22000 6.10300   -26.23500 1.000 216.16764 ? 221 ALA F O   1 
ATOM 1400 C CB  . ALA A 1 221 ? -10.92200 7.37500   -23.20600 1.000 227.56568 ? 221 ALA F CB  1 
ATOM 1401 N N   . GLU A 1 222 ? -10.33400 4.62800   -24.79800 1.000 212.07761 ? 222 GLU F N   1 
ATOM 1402 C CA  . GLU A 1 222 ? -9.65800  3.92600   -25.88100 1.000 207.79247 ? 222 GLU F CA  1 
ATOM 1403 C C   . GLU A 1 222 ? -10.68300 3.18600   -26.72500 1.000 209.15077 ? 222 GLU F C   1 
ATOM 1404 O O   . GLU A 1 222 ? -10.57900 3.14800   -27.96100 1.000 213.81995 ? 222 GLU F O   1 
ATOM 1405 C CB  . GLU A 1 222 ? -8.53200  3.03800   -25.36300 1.000 197.21393 ? 222 GLU F CB  1 
ATOM 1406 C CG  . GLU A 1 222 ? -7.47000  3.87800   -24.67900 1.000 193.76251 ? 222 GLU F CG  1 
ATOM 1407 C CD  . GLU A 1 222 ? -6.55200  3.08700   -23.80500 1.000 188.27654 ? 222 GLU F CD  1 
ATOM 1408 O OE1 . GLU A 1 222 ? -6.86800  1.91900   -23.53400 1.000 190.18973 ? 222 GLU F OE1 1 
ATOM 1409 O OE2 . GLU A 1 222 ? -5.47800  3.61000   -23.44400 1.000 189.61717 ? 222 GLU F OE2 1 
ATOM 1410 N N   . LEU A 1 223 ? -11.71200 2.64200   -26.07100 1.000 203.95057 ? 223 LEU F N   1 
ATOM 1411 C CA  . LEU A 1 223 ? -12.79100 1.99900   -26.81000 1.000 202.24329 ? 223 LEU F CA  1 
ATOM 1412 C C   . LEU A 1 223 ? -13.50100 2.97000   -27.73400 1.000 204.02157 ? 223 LEU F C   1 
ATOM 1413 O O   . LEU A 1 223 ? -13.79200 2.65400   -28.88500 1.000 205.93558 ? 223 LEU F O   1 
ATOM 1414 C CB  . LEU A 1 223 ? -13.81600 1.44600   -25.82000 1.000 196.79937 ? 223 LEU F CB  1 
ATOM 1415 C CG  . LEU A 1 223 ? -15.09200 0.99000   -26.52200 1.000 193.98027 ? 223 LEU F CG  1 
ATOM 1416 C CD1 . LEU A 1 223 ? -14.79600 -0.10500  -27.53100 1.000 196.14311 ? 223 LEU F CD1 1 
ATOM 1417 C CD2 . LEU A 1 223 ? -16.11600 0.55300   -25.50300 1.000 195.22398 ? 223 LEU F CD2 1 
ATOM 1418 N N   . ALA A 1 224 ? -13.76700 4.15600   -27.25200 1.000 204.73163 ? 224 ALA F N   1 
ATOM 1419 C CA  . ALA A 1 224 ? -14.36200 5.20600   -28.05200 1.000 209.93439 ? 224 ALA F CA  1 
ATOM 1420 C C   . ALA A 1 224 ? -13.45200 5.70200   -29.17100 1.000 214.72161 ? 224 ALA F C   1 
ATOM 1421 O O   . ALA A 1 224 ? -13.93300 5.90300   -30.28600 1.000 217.66945 ? 224 ALA F O   1 
ATOM 1422 C CB  . ALA A 1 224 ? -14.74800 6.36300   -27.14000 1.000 215.22589 ? 224 ALA F CB  1 
ATOM 1423 N N   . ARG A 1 225 ? -12.13000 5.75000   -28.96500 1.000 214.13867 ? 225 ARG F N   1 
ATOM 1424 C CA  . ARG A 1 225 ? -11.28200 6.23600   -30.05400 1.000 210.56030 ? 225 ARG F CA  1 
ATOM 1425 C C   . ARG A 1 225 ? -11.28200 5.20800   -31.16400 1.000 209.18807 ? 225 ARG F C   1 
ATOM 1426 O O   . ARG A 1 225 ? -11.35600 5.54600   -32.35900 1.000 210.80372 ? 225 ARG F O   1 
ATOM 1427 C CB  . ARG A 1 225 ? -9.86300  6.53700   -29.55600 1.000 211.01788 ? 225 ARG F CB  1 
ATOM 1428 C CG  . ARG A 1 225 ? -9.71100  7.96900   -28.97400 1.000 213.02490 ? 225 ARG F CG  1 
ATOM 1429 C CD  . ARG A 1 225 ? -8.27300  8.35200   -28.50200 1.000 227.20433 ? 225 ARG F CD  1 
ATOM 1430 N NE  . ARG A 1 225 ? -7.60400  7.59600   -27.43900 1.000 228.94458 ? 225 ARG F NE  1 
ATOM 1431 C CZ  . ARG A 1 225 ? -7.49800  7.98800   -26.17100 1.000 224.29397 ? 225 ARG F CZ  1 
ATOM 1432 N NH1 . ARG A 1 225 ? -8.01200  9.13700   -25.75400 1.000 230.28493 ? 225 ARG F NH1 1 
ATOM 1433 N NH2 . ARG A 1 225 ? -6.80400  7.23900   -25.31300 1.000 213.82687 ? 225 ARG F NH2 1 
ATOM 1434 N N   . ALA A 1 226 ? -11.27500 3.94200   -30.77600 1.000 207.88506 ? 226 ALA F N   1 
ATOM 1435 C CA  . ALA A 1 226 ? -11.27700 2.90000   -31.77900 1.000 205.59538 ? 226 ALA F CA  1 
ATOM 1436 C C   . ALA A 1 226 ? -12.63400 2.79000   -32.48000 1.000 206.49793 ? 226 ALA F C   1 
ATOM 1437 O O   . ALA A 1 226 ? -12.68200 2.61600   -33.70400 1.000 207.16985 ? 226 ALA F O   1 
ATOM 1438 C CB  . ALA A 1 226 ? -10.90500 1.57500   -31.14600 1.000 205.55584 ? 226 ALA F CB  1 
ATOM 1439 N N   . VAL A 1 227 ? -13.75500 2.87600   -31.73700 1.000 207.70468 ? 227 VAL F N   1 
ATOM 1440 C CA  . VAL A 1 227 ? -15.07400 2.79500   -32.38100 1.000 205.64150 ? 227 VAL F CA  1 
ATOM 1441 C C   . VAL A 1 227 ? -15.25900 3.95100   -33.35800 1.000 201.90081 ? 227 VAL F C   1 
ATOM 1442 O O   . VAL A 1 227 ? -15.86500 3.81000   -34.43200 1.000 197.43173 ? 227 VAL F O   1 
ATOM 1443 C CB  . VAL A 1 227 ? -16.20800 2.80500   -31.34000 1.000 205.57584 ? 227 VAL F CB  1 
ATOM 1444 C CG1 . VAL A 1 227 ? -17.50700 2.99000   -32.07100 1.000 198.92273 ? 227 VAL F CG1 1 
ATOM 1445 C CG2 . VAL A 1 227 ? -16.21600 1.59000   -30.44800 1.000 209.02894 ? 227 VAL F CG2 1 
ATOM 1446 N N   . SER A 1 228 ? -14.83000 5.13600   -32.93400 1.000 205.92628 ? 228 SER F N   1 
ATOM 1447 C CA  . SER A 1 228 ? -14.88300 6.34600   -33.72900 1.000 210.03381 ? 228 SER F CA  1 
ATOM 1448 C C   . SER A 1 228 ? -14.04300 6.27200   -34.99200 1.000 214.77337 ? 228 SER F C   1 
ATOM 1449 O O   . SER A 1 228 ? -14.45800 6.80200   -36.02000 1.000 218.22478 ? 228 SER F O   1 
ATOM 1450 C CB  . SER A 1 228 ? -14.34900 7.51300   -32.88600 1.000 219.30044 ? 228 SER F CB  1 
ATOM 1451 O OG  . SER A 1 228 ? -15.09800 7.70100   -31.70000 1.000 222.20145 ? 228 SER F OG  1 
ATOM 1452 N N   . ASN A 1 229 ? -13.01100 5.44700   -35.02100 1.000 215.08687 ? 229 ASN F N   1 
ATOM 1453 C CA  . ASN A 1 229 ? -12.16400 5.44000   -36.20300 1.000 213.30429 ? 229 ASN F CA  1 
ATOM 1454 C C   . ASN A 1 229 ? -12.59800 4.45100   -37.30600 1.000 202.87533 ? 229 ASN F C   1 
ATOM 1455 O O   . ASN A 1 229 ? -11.89800 4.31700   -38.31900 1.000 186.32280 ? 229 ASN F O   1 
ATOM 1456 C CB  . ASN A 1 229 ? -10.73200 5.25500   -35.71700 1.000 222.57055 ? 229 ASN F CB  1 
ATOM 1457 C CG  . ASN A 1 229 ? -10.01000 6.60900   -35.57300 1.000 228.73837 ? 229 ASN F CG  1 
ATOM 1458 O OD1 . ASN A 1 229 ? -9.98800  7.40200   -36.50800 1.000 228.59149 ? 229 ASN F OD1 1 
ATOM 1459 N ND2 . ASN A 1 229 ? -9.51100  6.90800   -34.36400 1.000 225.13918 ? 229 ASN F ND2 1 
ATOM 1460 N N   . MET A 1 230 ? -13.74500 3.79800   -37.12900 1.000 206.44644 ? 230 MET F N   1 
ATOM 1461 C CA  . MET A 1 230 ? -14.26700 2.77600   -38.02400 1.000 206.47005 ? 230 MET F CA  1 
ATOM 1462 C C   . MET A 1 230 ? -14.67700 3.39600   -39.36900 1.000 205.80307 ? 230 MET F C   1 
ATOM 1463 O O   . MET A 1 230 ? -14.98200 4.57800   -39.44300 1.000 213.46328 ? 230 MET F O   1 
ATOM 1464 C CB  . MET A 1 230 ? -15.50800 2.11500   -37.42700 1.000 207.45463 ? 230 MET F CB  1 
ATOM 1465 C CG  . MET A 1 230 ? -15.33900 1.15300   -36.29500 1.000 206.10160 ? 230 MET F CG  1 
ATOM 1466 S SD  . MET A 1 230 ? -17.01600 0.64900   -35.87200 1.000 199.15919 ? 230 MET F SD  1 
ATOM 1467 C CE  . MET A 1 230 ? -16.73000 -0.68900  -34.72200 1.000 198.64985 ? 230 MET F CE  1 
ATOM 1468 N N   . PRO A 1 231 ? -14.56900 2.63500   -40.48500 1.000 204.39842 ? 231 PRO F N   1 
ATOM 1469 C CA  . PRO A 1 231 ? -14.93900 2.98000   -41.89200 1.000 204.54659 ? 231 PRO F CA  1 
ATOM 1470 C C   . PRO A 1 231 ? -16.40300 2.82800   -42.31400 1.000 202.18002 ? 231 PRO F C   1 
ATOM 1471 O O   . PRO A 1 231 ? -16.77500 1.90000   -43.02200 1.000 208.49769 ? 231 PRO F O   1 
ATOM 1472 C CB  . PRO A 1 231 ? -14.04800 2.01500   -42.68200 1.000 216.37413 ? 231 PRO F CB  1 
ATOM 1473 C CG  . PRO A 1 231 ? -13.68600 0.85500   -41.60400 1.000 213.30701 ? 231 PRO F CG  1 
ATOM 1474 C CD  . PRO A 1 231 ? -14.51200 1.16600   -40.40300 1.000 207.82934 ? 231 PRO F CD  1 
ATOM 1475 N N   . THR A 1 232 ? -17.30800 3.69300   -41.88100 1.000 197.70507 ? 232 THR F N   1 
ATOM 1476 C CA  . THR A 1 232 ? -18.69500 3.59900   -42.35600 1.000 199.94653 ? 232 THR F CA  1 
ATOM 1477 C C   . THR A 1 232 ? -19.25900 5.02200   -42.33900 1.000 202.69326 ? 232 THR F C   1 
ATOM 1478 O O   . THR A 1 232 ? -18.51200 5.98800   -42.16000 1.000 201.46591 ? 232 THR F O   1 
ATOM 1479 C CB  . THR A 1 232 ? -19.48600 2.52400   -41.57700 1.000 198.70055 ? 232 THR F CB  1 
ATOM 1480 O OG1 . THR A 1 232 ? -20.81000 2.36400   -42.12500 1.000 204.30970 ? 232 THR F OG1 1 
ATOM 1481 C CG2 . THR A 1 232 ? -19.57000 2.84300   -40.09100 1.000 199.31391 ? 232 THR F CG2 1 
ATOM 1482 N N   . SER A 1 233 ? -20.55900 5.17900   -42.59100 1.000 206.93535 ? 233 SER F N   1 
ATOM 1483 C CA  . SER A 1 233 ? -21.11500 6.51300   -42.76800 1.000 205.30337 ? 233 SER F CA  1 
ATOM 1484 C C   . SER A 1 233 ? -21.42300 7.07500   -41.37600 1.000 203.41952 ? 233 SER F C   1 
ATOM 1485 O O   . SER A 1 233 ? -21.23400 6.40400   -40.35900 1.000 199.64579 ? 233 SER F O   1 
ATOM 1486 C CB  . SER A 1 233 ? -22.33300 6.45500   -43.71500 1.000 202.42986 ? 233 SER F CB  1 
ATOM 1487 O OG  . SER A 1 233 ? -23.10800 7.64800   -43.75500 1.000 208.85778 ? 233 SER F OG  1 
ATOM 1488 N N   . ALA A 1 234 ? -21.83700 8.33500   -41.31100 1.000 206.70299 ? 234 ALA F N   1 
ATOM 1489 C CA  . ALA A 1 234 ? -21.90200 8.99200   -40.00900 1.000 208.32113 ? 234 ALA F CA  1 
ATOM 1490 C C   . ALA A 1 234 ? -22.93900 8.38200   -39.07700 1.000 202.12722 ? 234 ALA F C   1 
ATOM 1491 O O   . ALA A 1 234 ? -22.62800 8.11000   -37.90400 1.000 201.16102 ? 234 ALA F O   1 
ATOM 1492 C CB  . ALA A 1 234 ? -22.19100 10.47000  -40.19600 1.000 225.87594 ? 234 ALA F CB  1 
ATOM 1493 N N   . GLY A 1 235 ? -24.14600 8.10200   -39.57700 1.000 201.14394 ? 235 GLY F N   1 
ATOM 1494 C CA  . GLY A 1 235 ? -25.16400 7.55200   -38.70000 1.000 202.39987 ? 235 GLY F CA  1 
ATOM 1495 C C   . GLY A 1 235 ? -24.75300 6.23500   -38.06000 1.000 199.09497 ? 235 GLY F C   1 
ATOM 1496 O O   . GLY A 1 235 ? -25.06600 5.98600   -36.88900 1.000 196.36710 ? 235 GLY F O   1 
ATOM 1497 N N   . GLN A 1 236 ? -24.05300 5.36700   -38.81300 1.000 201.19320 ? 236 GLN F N   1 
ATOM 1498 C CA  . GLN A 1 236 ? -23.56700 4.11400   -38.22100 1.000 204.93651 ? 236 GLN F CA  1 
ATOM 1499 C C   . GLN A 1 236 ? -22.52000 4.30000   -37.10900 1.000 202.94055 ? 236 GLN F C   1 
ATOM 1500 O O   . GLN A 1 236 ? -22.64400 3.68700   -36.04600 1.000 207.84531 ? 236 GLN F O   1 
ATOM 1501 C CB  . GLN A 1 236 ? -22.99400 3.16300   -39.29200 1.000 209.44436 ? 236 GLN F CB  1 
ATOM 1502 C CG  . GLN A 1 236 ? -23.95700 2.48000   -40.28800 1.000 208.96218 ? 236 GLN F CG  1 
ATOM 1503 C CD  . GLN A 1 236 ? -24.31800 3.31400   -41.49800 1.000 208.25931 ? 236 GLN F CD  1 
ATOM 1504 O OE1 . GLN A 1 236 ? -24.55700 4.51500   -41.39700 1.000 212.03145 ? 236 GLN F OE1 1 
ATOM 1505 N NE2 . GLN A 1 236 ? -24.36800 2.67000   -42.65600 1.000 204.16139 ? 236 GLN F NE2 1 
ATOM 1506 N N   . ILE A 1 237 ? -21.48800 5.13300   -37.29700 1.000 197.16568 ? 237 ILE F N   1 
ATOM 1507 C CA  . ILE A 1 237 ? -20.50800 5.26000   -36.21100 1.000 192.46720 ? 237 ILE F CA  1 
ATOM 1508 C C   . ILE A 1 237 ? -21.10700 5.91100   -34.98400 1.000 191.28265 ? 237 ILE F C   1 
ATOM 1509 O O   . ILE A 1 237 ? -20.83200 5.50500   -33.84400 1.000 184.85020 ? 237 ILE F O   1 
ATOM 1510 C CB  . ILE A 1 237 ? -19.27800 6.03300   -36.66000 1.000 187.50628 ? 237 ILE F CB  1 
ATOM 1511 C CG1 . ILE A 1 237 ? -18.48600 5.13600   -37.54400 1.000 202.22948 ? 237 ILE F CG1 1 
ATOM 1512 C CG2 . ILE A 1 237 ? -18.41000 6.29800   -35.45500 1.000 179.48349 ? 237 ILE F CG2 1 
ATOM 1513 C CD1 . ILE A 1 237 ? -17.46400 5.88400   -38.20900 1.000 219.57982 ? 237 ILE F CD1 1 
ATOM 1514 N N   . LYS A 1 238 ? -21.97000 6.90200   -35.20200 1.000 198.16126 ? 238 LYS F N   1 
ATOM 1515 C CA  . LYS A 1 238 ? -22.61300 7.58700   -34.08800 1.000 205.52730 ? 238 LYS F CA  1 
ATOM 1516 C C   . LYS A 1 238 ? -23.52700 6.65200   -33.30100 1.000 202.84550 ? 238 LYS F C   1 
ATOM 1517 O O   . LYS A 1 238 ? -23.36600 6.48500   -32.07900 1.000 196.56252 ? 238 LYS F O   1 
ATOM 1518 C CB  . LYS A 1 238 ? -23.39500 8.77100   -34.70700 1.000 215.09596 ? 238 LYS F CB  1 
ATOM 1519 C CG  . LYS A 1 238 ? -24.22400 9.73500   -33.85300 1.000 218.38979 ? 238 LYS F CG  1 
ATOM 1520 C CD  . LYS A 1 238 ? -25.07600 10.66800  -34.77800 1.000 213.89345 ? 238 LYS F CD  1 
ATOM 1521 C CE  . LYS A 1 238 ? -26.03400 9.94000   -35.76200 1.000 207.51109 ? 238 LYS F CE  1 
ATOM 1522 N NZ  . LYS A 1 238 ? -27.31000 9.37100   -35.24900 1.000 197.66753 ? 238 LYS F NZ  1 
ATOM 1523 N N   . LEU A 1 239 ? -24.33400 5.87000   -34.01700 1.000 203.72634 ? 239 LEU F N   1 
ATOM 1524 C CA  . LEU A 1 239 ? -25.22700 4.91300   -33.37900 1.000 206.12282 ? 239 LEU F CA  1 
ATOM 1525 C C   . LEU A 1 239 ? -24.44300 3.81300   -32.64800 1.000 206.45343 ? 239 LEU F C   1 
ATOM 1526 O O   . LEU A 1 239 ? -24.78100 3.46300   -31.51300 1.000 206.94376 ? 239 LEU F O   1 
ATOM 1527 C CB  . LEU A 1 239 ? -26.23700 4.44100   -34.42700 1.000 204.52614 ? 239 LEU F CB  1 
ATOM 1528 C CG  . LEU A 1 239 ? -27.41800 3.54200   -34.15700 1.000 211.96506 ? 239 LEU F CG  1 
ATOM 1529 C CD1 . LEU A 1 239 ? -28.41700 3.95000   -35.22000 1.000 203.91878 ? 239 LEU F CD1 1 
ATOM 1530 C CD2 . LEU A 1 239 ? -27.08800 2.08000   -34.25200 1.000 214.36850 ? 239 LEU F CD2 1 
ATOM 1531 N N   . MET A 1 240 ? -23.34900 3.30700   -33.24800 1.000 206.49383 ? 240 MET F N   1 
ATOM 1532 C CA  . MET A 1 240 ? -22.52900 2.26200   -32.60700 1.000 207.34145 ? 240 MET F CA  1 
ATOM 1533 C C   . MET A 1 240 ? -21.89900 2.80200   -31.32900 1.000 198.35780 ? 240 MET F C   1 
ATOM 1534 O O   . MET A 1 240 ? -21.75400 2.09600   -30.31900 1.000 197.71240 ? 240 MET F O   1 
ATOM 1535 C CB  . MET A 1 240 ? -21.41200 1.75400   -33.54500 1.000 209.47566 ? 240 MET F CB  1 
ATOM 1536 C CG  . MET A 1 240 ? -21.76400 0.63800   -34.57600 1.000 203.69072 ? 240 MET F CG  1 
ATOM 1537 S SD  . MET A 1 240 ? -20.34200 0.07600   -35.58100 1.000 178.07150 ? 240 MET F SD  1 
ATOM 1538 C CE  . MET A 1 240 ? -20.12300 1.53400   -36.60500 1.000 197.05186 ? 240 MET F CE  1 
ATOM 1539 N N   . LEU A 1 241 ? -21.51400 4.06000   -31.37800 1.000 190.93116 ? 241 LEU F N   1 
ATOM 1540 C CA  . LEU A 1 241 ? -20.91500 4.73000   -30.24700 1.000 188.33555 ? 241 LEU F CA  1 
ATOM 1541 C C   . LEU A 1 241 ? -21.90100 4.80200   -29.09200 1.000 194.39532 ? 241 LEU F C   1 
ATOM 1542 O O   . LEU A 1 241 ? -21.55400 4.47500   -27.95100 1.000 199.15710 ? 241 LEU F O   1 
ATOM 1543 C CB  . LEU A 1 241 ? -20.41700 6.08400   -30.72400 1.000 181.97320 ? 241 LEU F CB  1 
ATOM 1544 C CG  . LEU A 1 241 ? -19.03300 5.65000   -31.17800 1.000 181.15437 ? 241 LEU F CG  1 
ATOM 1545 C CD1 . LEU A 1 241 ? -18.17200 6.68300   -31.79500 1.000 185.12835 ? 241 LEU F CD1 1 
ATOM 1546 C CD2 . LEU A 1 241 ? -18.35700 5.23300   -29.86900 1.000 192.10845 ? 241 LEU F CD2 1 
ATOM 1547 N N   . GLU A 1 242 ? -23.14500 5.18200   -29.39000 1.000 197.68983 ? 242 GLU F N   1 
ATOM 1548 C CA  . GLU A 1 242 ? -24.19100 5.27500   -28.33700 1.000 211.91249 ? 242 GLU F CA  1 
ATOM 1549 C C   . GLU A 1 242 ? -24.15100 4.02400   -27.45400 1.000 207.04503 ? 242 GLU F C   1 
ATOM 1550 O O   . GLU A 1 242 ? -23.99000 4.15800   -26.22700 1.000 216.55397 ? 242 GLU F O   1 
ATOM 1551 C CB  . GLU A 1 242 ? -25.56800 5.40700   -28.98600 1.000 221.50916 ? 242 GLU F CB  1 
ATOM 1552 C CG  . GLU A 1 242 ? -25.68100 6.59800   -29.91600 1.000 222.29575 ? 242 GLU F CG  1 
ATOM 1553 C CD  . GLU A 1 242 ? -26.84700 6.52500   -30.88500 1.000 229.41827 ? 242 GLU F CD  1 
ATOM 1554 O OE1 . GLU A 1 242 ? -27.59800 5.53100   -30.82800 1.000 237.72753 ? 242 GLU F OE1 1 
ATOM 1555 O OE2 . GLU A 1 242 ? -26.99300 7.45400   -31.70300 1.000 227.26321 ? 242 GLU F OE2 1 
ATOM 1556 N N   . ASN A 1 243 ? -24.29900 2.85900   -28.08400 1.000 194.58496 ? 243 ASN F N   1 
ATOM 1557 C CA  . ASN A 1 243 ? -24.57800 1.58500   -27.44900 1.000 186.53857 ? 243 ASN F CA  1 
ATOM 1558 C C   . ASN A 1 243 ? -23.31300 0.80500   -27.49600 1.000 189.56200 ? 243 ASN F C   1 
ATOM 1559 O O   . ASN A 1 243 ? -23.25000 -0.32600  -27.97500 1.000 195.43423 ? 243 ASN F O   1 
ATOM 1560 C CB  . ASN A 1 243 ? -25.80800 0.83700   -27.96200 1.000 188.24957 ? 243 ASN F CB  1 
ATOM 1561 C CG  . ASN A 1 243 ? -27.09600 1.65100   -27.85900 1.000 186.71851 ? 243 ASN F CG  1 
ATOM 1562 O OD1 . ASN A 1 243 ? -27.73800 1.67800   -26.80000 1.000 186.85311 ? 243 ASN F OD1 1 
ATOM 1563 N ND2 . ASN A 1 243 ? -27.54500 2.19900   -28.97100 1.000 188.49710 ? 243 ASN F ND2 1 
ATOM 1564 N N   . ARG A 1 244 ? -22.25400 1.44800   -27.03300 1.000 190.10112 ? 244 ARG F N   1 
ATOM 1565 C CA  . ARG A 1 244 ? -20.96100 0.86000   -27.25400 1.000 198.99884 ? 244 ARG F CA  1 
ATOM 1566 C C   . ARG A 1 244 ? -20.77200 -0.36500  -26.41200 1.000 206.44623 ? 244 ARG F C   1 
ATOM 1567 O O   . ARG A 1 244 ? -19.78100 -1.07700  -26.61200 1.000 210.07199 ? 244 ARG F O   1 
ATOM 1568 C CB  . ARG A 1 244 ? -19.83700 1.76100   -26.79800 1.000 201.30059 ? 244 ARG F CB  1 
ATOM 1569 C CG  . ARG A 1 244 ? -19.97000 2.09100   -25.32400 1.000 202.52269 ? 244 ARG F CG  1 
ATOM 1570 C CD  . ARG A 1 244 ? -18.74800 2.81900   -25.02200 1.000 209.29168 ? 244 ARG F CD  1 
ATOM 1571 N NE  . ARG A 1 244 ? -18.86100 4.23800   -25.26500 1.000 216.35093 ? 244 ARG F NE  1 
ATOM 1572 C CZ  . ARG A 1 244 ? -17.80100 5.02700   -25.30300 1.000 220.80819 ? 244 ARG F CZ  1 
ATOM 1573 N NH1 . ARG A 1 244 ? -16.58000 4.54100   -25.13200 1.000 219.63546 ? 244 ARG F NH1 1 
ATOM 1574 N NH2 . ARG A 1 244 ? -17.96700 6.33300   -25.49600 1.000 224.48470 ? 244 ARG F NH2 1 
ATOM 1575 N N   . ALA A 1 245 ? -21.65800 -0.59200  -25.44600 1.000 210.23164 ? 245 ALA F N   1 
ATOM 1576 C CA  . ALA A 1 245 ? -21.60900 -1.84900  -24.71600 1.000 219.82441 ? 245 ALA F CA  1 
ATOM 1577 C C   . ALA A 1 245 ? -21.91200 -3.04900  -25.64600 1.000 223.69671 ? 245 ALA F C   1 
ATOM 1578 O O   . ALA A 1 245 ? -21.37000 -4.14400  -25.42400 1.000 223.44027 ? 245 ALA F O   1 
ATOM 1579 C CB  . ALA A 1 245 ? -22.55300 -1.78200  -23.50700 1.000 220.23236 ? 245 ALA F CB  1 
ATOM 1580 N N   . MET A 1 246 ? -22.71700 -2.85500  -26.72600 1.000 221.48409 ? 246 MET F N   1 
ATOM 1581 C CA  . MET A 1 246 ? -22.93400 -3.91600  -27.72700 1.000 208.93316 ? 246 MET F CA  1 
ATOM 1582 C C   . MET A 1 246 ? -21.71900 -4.12400  -28.60600 1.000 197.98832 ? 246 MET F C   1 
ATOM 1583 O O   . MET A 1 246 ? -21.43700 -5.24900  -29.03300 1.000 191.50756 ? 246 MET F O   1 
ATOM 1584 C CB  . MET A 1 246 ? -24.17000 -3.62500  -28.55700 1.000 204.00443 ? 246 MET F CB  1 
ATOM 1585 C CG  . MET A 1 246 ? -25.38800 -4.29900  -28.01100 1.000 215.60035 ? 246 MET F CG  1 
ATOM 1586 S SD  . MET A 1 246 ? -25.92900 -3.74000  -26.38000 1.000 257.98244 ? 246 MET F SD  1 
ATOM 1587 C CE  . MET A 1 246 ? -25.84900 -1.96800  -26.42900 1.000 231.26798 ? 246 MET F CE  1 
ATOM 1588 N N   . VAL A 1 247 ? -21.01800 -3.05400  -28.93200 1.000 195.35157 ? 247 VAL F N   1 
ATOM 1589 C CA  . VAL A 1 247 ? -19.74000 -3.23800  -29.58500 1.000 189.98998 ? 247 VAL F CA  1 
ATOM 1590 C C   . VAL A 1 247 ? -18.81900 -4.05400  -28.67900 1.000 190.74403 ? 247 VAL F C   1 
ATOM 1591 O O   . VAL A 1 247 ? -18.05800 -4.89500  -29.16100 1.000 189.16807 ? 247 VAL F O   1 
ATOM 1592 C CB  . VAL A 1 247 ? -19.17300 -1.88800  -30.01000 1.000 187.26192 ? 247 VAL F CB  1 
ATOM 1593 C CG1 . VAL A 1 247 ? -17.87700 -2.08500  -30.68300 1.000 186.25598 ? 247 VAL F CG1 1 
ATOM 1594 C CG2 . VAL A 1 247 ? -20.15400 -1.27500  -30.95600 1.000 187.04427 ? 247 VAL F CG2 1 
ATOM 1595 N N   . ARG A 1 248 ? -18.78500 -3.74600  -27.37100 1.000 193.33798 ? 248 ARG F N   1 
ATOM 1596 C CA  . ARG A 1 248 ? -18.02600 -4.59000  -26.43200 1.000 191.45986 ? 248 ARG F CA  1 
ATOM 1597 C C   . ARG A 1 248 ? -18.46200 -6.05900  -26.49500 1.000 191.17937 ? 248 ARG F C   1 
ATOM 1598 O O   . ARG A 1 248 ? -17.62600 -6.96500  -26.57400 1.000 187.47955 ? 248 ARG F O   1 
ATOM 1599 C CB  . ARG A 1 248 ? -18.12900 -4.08700  -24.97100 1.000 192.72889 ? 248 ARG F CB  1 
ATOM 1600 C CG  . ARG A 1 248 ? -17.24400 -2.87900  -24.55900 1.000 190.58146 ? 248 ARG F CG  1 
ATOM 1601 C CD  . ARG A 1 248 ? -17.56100 -2.30300  -23.15500 1.000 181.17890 ? 248 ARG F CD  1 
ATOM 1602 N NE  . ARG A 1 248 ? -16.77400 -1.11000  -22.84800 1.000 180.33228 ? 248 ARG F NE  1 
ATOM 1603 C CZ  . ARG A 1 248 ? -15.46200 -1.10800  -22.64300 1.000 191.75877 ? 248 ARG F CZ  1 
ATOM 1604 N NH1 . ARG A 1 248 ? -14.74900 -2.21700  -22.70700 1.000 195.63364 ? 248 ARG F NH1 1 
ATOM 1605 N NH2 . ARG A 1 248 ? -14.84400 0.04000   -22.38600 1.000 195.89150 ? 248 ARG F NH2 1 
ATOM 1606 N N   . ARG A 1 249 ? -19.77300 -6.31600  -26.43900 1.000 196.50176 ? 249 ARG F N   1 
ATOM 1607 C CA  . ARG A 1 249 ? -20.25600 -7.69600  -26.33500 1.000 204.78237 ? 249 ARG F CA  1 
ATOM 1608 C C   . ARG A 1 249 ? -20.03800 -8.50400  -27.60500 1.000 201.05326 ? 249 ARG F C   1 
ATOM 1609 O O   . ARG A 1 249 ? -19.68800 -9.69200  -27.53600 1.000 199.83624 ? 249 ARG F O   1 
ATOM 1610 C CB  . ARG A 1 249 ? -21.77100 -7.72800  -26.08400 1.000 219.55506 ? 249 ARG F CB  1 
ATOM 1611 C CG  . ARG A 1 249 ? -22.36600 -7.28100  -24.75600 1.000 224.43770 ? 249 ARG F CG  1 
ATOM 1612 C CD  . ARG A 1 249 ? -23.94300 -7.38800  -24.81500 1.000 232.54032 ? 249 ARG F CD  1 
ATOM 1613 N NE  . ARG A 1 249 ? -24.55500 -8.55200  -25.48200 1.000 243.20498 ? 249 ARG F NE  1 
ATOM 1614 C CZ  . ARG A 1 249 ? -24.63400 -9.78200  -24.97300 1.000 246.89624 ? 249 ARG F CZ  1 
ATOM 1615 N NH1 . ARG A 1 249 ? -24.14000 -10.07000 -23.77900 1.000 248.63932 ? 249 ARG F NH1 1 
ATOM 1616 N NH2 . ARG A 1 249 ? -25.25800 -10.74000 -25.66100 1.000 243.51097 ? 249 ARG F NH2 1 
ATOM 1617 N N   . LYS A 1 250 ? -20.05900 -7.84700  -28.75100 1.000 197.59387 ? 250 LYS F N   1 
ATOM 1618 C CA  . LYS A 1 250 ? -19.96800 -8.52800  -30.03300 1.000 205.38392 ? 250 LYS F CA  1 
ATOM 1619 C C   . LYS A 1 250 ? -18.56000 -8.60400  -30.54600 1.000 202.70484 ? 250 LYS F C   1 
ATOM 1620 O O   . LYS A 1 250 ? -18.29700 -9.32800  -31.50800 1.000 208.12954 ? 250 LYS F O   1 
ATOM 1621 C CB  . LYS A 1 250 ? -20.82900 -7.83300  -31.10100 1.000 214.25409 ? 250 LYS F CB  1 
ATOM 1622 C CG  . LYS A 1 250 ? -22.36900 -7.80700  -31.09900 1.000 219.34557 ? 250 LYS F CG  1 
ATOM 1623 C CD  . LYS A 1 250 ? -22.89700 -9.24200  -31.18400 1.000 229.16117 ? 250 LYS F CD  1 
ATOM 1624 C CE  . LYS A 1 250 ? -24.36400 -9.40400  -30.87800 1.000 236.50199 ? 250 LYS F CE  1 
ATOM 1625 N NZ  . LYS A 1 250 ? -24.70300 -10.87200 -30.91200 1.000 230.15828 ? 250 LYS F NZ  1 
ATOM 1626 N N   . GLY A 1 251 ? -17.62300 -7.98400  -29.85700 1.000 197.84280 ? 251 GLY F N   1 
ATOM 1627 C CA  . GLY A 1 251 ? -16.24600 -8.06000  -30.25300 1.000 201.39566 ? 251 GLY F CA  1 
ATOM 1628 C C   . GLY A 1 251 ? -15.57500 -9.05500  -29.34800 1.000 204.47913 ? 251 GLY F C   1 
ATOM 1629 O O   . GLY A 1 251 ? -16.21600 -9.70000  -28.52000 1.000 202.10969 ? 251 GLY F O   1 
ATOM 1630 N N   . PHE A 1 252 ? -14.28700 -9.24300  -29.60100 1.000 208.60184 ? 252 PHE F N   1 
ATOM 1631 C CA  . PHE A 1 252 ? -13.48700 -10.20600 -28.86300 1.000 207.28091 ? 252 PHE F CA  1 
ATOM 1632 C C   . PHE A 1 252 ? -12.01100 -9.85900  -28.99900 1.000 199.18608 ? 252 PHE F C   1 
ATOM 1633 O O   . PHE A 1 252 ? -11.62600 -8.93500  -29.71300 1.000 199.02688 ? 252 PHE F O   1 
ATOM 1634 C CB  . PHE A 1 252 ? -13.88500 -11.63300 -29.23500 1.000 207.28863 ? 252 PHE F CB  1 
ATOM 1635 C CG  . PHE A 1 252 ? -13.65800 -11.98000 -30.63700 1.000 201.11609 ? 252 PHE F CG  1 
ATOM 1636 C CD1 . PHE A 1 252 ? -14.50300 -11.46200 -31.60000 1.000 201.86171 ? 252 PHE F CD1 1 
ATOM 1637 C CD2 . PHE A 1 252 ? -12.67200 -12.86600 -30.99600 1.000 195.54625 ? 252 PHE F CD2 1 
ATOM 1638 C CE1 . PHE A 1 252 ? -14.34900 -11.77800 -32.89200 1.000 202.64416 ? 252 PHE F CE1 1 
ATOM 1639 C CE2 . PHE A 1 252 ? -12.51100 -13.19800 -32.29800 1.000 200.92578 ? 252 PHE F CE2 1 
ATOM 1640 C CZ  . PHE A 1 252 ? -13.35700 -12.65100 -33.25900 1.000 204.63625 ? 252 PHE F CZ  1 
ATOM 1641 N N   . GLY A 1 253 ? -11.19100 -10.57900 -28.25800 1.000 192.56767 ? 253 GLY F N   1 
ATOM 1642 C CA  . GLY A 1 253 ? -9.78300  -10.27600 -28.19200 1.000 193.02660 ? 253 GLY F CA  1 
ATOM 1643 C C   . GLY A 1 253 ? -8.90700  -11.46100 -28.51300 1.000 192.66678 ? 253 GLY F C   1 
ATOM 1644 O O   . GLY A 1 253 ? -9.29800  -12.61900 -28.35600 1.000 186.61051 ? 253 GLY F O   1 
ATOM 1645 N N   . ILE A 1 254 ? -7.78100  -11.13900 -29.14200 1.000 201.37742 ? 254 ILE F N   1 
ATOM 1646 C CA  . ILE A 1 254 ? -6.78600  -12.10600 -29.56600 1.000 203.49666 ? 254 ILE F CA  1 
ATOM 1647 C C   . ILE A 1 254 ? -5.39200  -11.76400 -29.03700 1.000 200.56023 ? 254 ILE F C   1 
ATOM 1648 O O   . ILE A 1 254 ? -4.93900  -10.61200 -29.13900 1.000 200.95771 ? 254 ILE F O   1 
ATOM 1649 C CB  . ILE A 1 254 ? -6.77300  -12.14000 -31.08600 1.000 205.41699 ? 254 ILE F CB  1 
ATOM 1650 C CG1 . ILE A 1 254 ? -8.13100  -12.64200 -31.53500 1.000 201.90144 ? 254 ILE F CG1 1 
ATOM 1651 C CG2 . ILE A 1 254 ? -5.59500  -12.97500 -31.54100 1.000 206.14799 ? 254 ILE F CG2 1 
ATOM 1652 C CD1 . ILE A 1 254 ? -8.24600  -12.68300 -32.98300 1.000 211.06246 ? 254 ILE F CD1 1 
ATOM 1653 N N   . LEU A 1 255 ? -4.72400  -12.75000 -28.44300 1.000 192.94238 ? 255 LEU F N   1 
ATOM 1654 C CA  . LEU A 1 255 ? -3.35800  -12.52600 -28.02000 1.000 189.86767 ? 255 LEU F CA  1 
ATOM 1655 C C   . LEU A 1 255 ? -2.45300  -12.56100 -29.23800 1.000 188.62078 ? 255 LEU F C   1 
ATOM 1656 O O   . LEU A 1 255 ? -2.51300  -13.51900 -30.01700 1.000 177.81116 ? 255 LEU F O   1 
ATOM 1657 C CB  . LEU A 1 255 ? -2.94300  -13.61500 -27.04200 1.000 196.34148 ? 255 LEU F CB  1 
ATOM 1658 C CG  . LEU A 1 255 ? -1.46200  -13.48100 -26.71700 1.000 212.65838 ? 255 LEU F CG  1 
ATOM 1659 C CD1 . LEU A 1 255 ? -1.28500  -12.13500 -26.04300 1.000 217.21701 ? 255 LEU F CD1 1 
ATOM 1660 C CD2 . LEU A 1 255 ? -0.91400  -14.61800 -25.84000 1.000 215.50519 ? 255 LEU F CD2 1 
ATOM 1661 N N   . ILE A 1 256 ? -1.61700  -11.53900 -29.41700 1.000 194.17537 ? 256 ILE F N   1 
ATOM 1662 C CA  . ILE A 1 256 ? -0.66000  -11.63600 -30.51100 1.000 205.10493 ? 256 ILE F CA  1 
ATOM 1663 C C   . ILE A 1 256 ? 0.69000   -12.20000 -30.03700 1.000 227.41989 ? 256 ILE F C   1 
ATOM 1664 O O   . ILE A 1 256 ? 1.25300   -13.08500 -30.68900 1.000 229.08961 ? 256 ILE F O   1 
ATOM 1665 C CB  . ILE A 1 256 ? -0.50700  -10.26900 -31.17500 1.000 204.69913 ? 256 ILE F CB  1 
ATOM 1666 C CG1 . ILE A 1 256 ? -1.85700  -9.77400  -31.63900 1.000 200.38255 ? 256 ILE F CG1 1 
ATOM 1667 C CG2 . ILE A 1 256 ? 0.29500   -10.45600 -32.43200 1.000 221.70697 ? 256 ILE F CG2 1 
ATOM 1668 C CD1 . ILE A 1 256 ? -2.43000  -10.64800 -32.64300 1.000 216.27155 ? 256 ILE F CD1 1 
ATOM 1669 N N   . GLY A 1 257 ? 1.23000   -11.68100 -28.92000 1.000 239.97142 ? 257 GLY F N   1 
ATOM 1670 C CA  . GLY A 1 257 ? 2.44200   -12.18100 -28.27000 1.000 244.89595 ? 257 GLY F CA  1 
ATOM 1671 C C   . GLY A 1 257 ? 3.25800   -11.13400 -27.51000 1.000 234.19936 ? 257 GLY F C   1 
ATOM 1672 O O   . GLY A 1 257 ? 2.98400   -9.93100  -27.53700 1.000 228.29143 ? 257 GLY F O   1 
ATOM 1673 N N   . VAL A 1 258 ? 4.31300   -11.63500 -26.84900 1.000 229.33293 ? 258 VAL F N   1 
ATOM 1674 C CA  . VAL A 1 258 ? 5.28900   -10.84700 -26.08500 1.000 228.90832 ? 258 VAL F CA  1 
ATOM 1675 C C   . VAL A 1 258 ? 6.66100   -10.78300 -26.75600 1.000 232.31814 ? 258 VAL F C   1 
ATOM 1676 O O   . VAL A 1 258 ? 7.26100   -11.83200 -27.02300 1.000 233.01423 ? 258 VAL F O   1 
ATOM 1677 C CB  . VAL A 1 258 ? 5.42500   -11.39800 -24.65900 1.000 235.09157 ? 258 VAL F CB  1 
ATOM 1678 C CG1 . VAL A 1 258 ? 6.49100   -10.60100 -23.88500 1.000 242.44652 ? 258 VAL F CG1 1 
ATOM 1679 C CG2 . VAL A 1 258 ? 4.06900   -11.38100 -23.96200 1.000 230.10515 ? 258 VAL F CG2 1 
ATOM 1680 N N   . TYR A 1 259 ? 7.19200   -9.58100  -26.99500 1.000 235.38393 ? 259 TYR F N   1 
ATOM 1681 C CA  . TYR A 1 259 ? 8.49500   -9.50400  -27.66300 1.000 242.10111 ? 259 TYR F CA  1 
ATOM 1682 C C   . TYR A 1 259 ? 9.49200   -8.63300  -26.88700 1.000 250.88883 ? 259 TYR F C   1 
ATOM 1683 O O   . TYR A 1 259 ? 9.44700   -7.41000  -27.03300 1.000 257.34745 ? 259 TYR F O   1 
ATOM 1684 C CB  . TYR A 1 259 ? 8.27700   -8.97500  -29.06200 1.000 241.22727 ? 259 TYR F CB  1 
ATOM 1685 C CG  . TYR A 1 259 ? 7.40700   -9.94800  -29.77600 1.000 236.27779 ? 259 TYR F CG  1 
ATOM 1686 C CD1 . TYR A 1 259 ? 7.89200   -11.16200 -30.23200 1.000 238.66455 ? 259 TYR F CD1 1 
ATOM 1687 C CD2 . TYR A 1 259 ? 6.05900   -9.67700  -29.92300 1.000 235.90421 ? 259 TYR F CD2 1 
ATOM 1688 C CE1 . TYR A 1 259 ? 7.05000   -12.06500 -30.85900 1.000 241.20098 ? 259 TYR F CE1 1 
ATOM 1689 C CE2 . TYR A 1 259 ? 5.22000   -10.55500 -30.54200 1.000 230.23725 ? 259 TYR F CE2 1 
ATOM 1690 C CZ  . TYR A 1 259 ? 5.71400   -11.75100 -31.01500 1.000 236.67917 ? 259 TYR F CZ  1 
ATOM 1691 O OH  . TYR A 1 259 ? 4.87200   -12.64600 -31.63900 1.000 234.01505 ? 259 TYR F OH  1 
ATOM 1692 N N   . GLY A 1 260 ? 10.42300  -9.19800  -26.10100 1.000 251.51238 ? 260 GLY F N   1 
ATOM 1693 C CA  . GLY A 1 260 ? 11.20800  -8.25600  -25.30800 1.000 248.36271 ? 260 GLY F CA  1 
ATOM 1694 C C   . GLY A 1 260 ? 10.48000  -7.52500  -24.18300 1.000 238.82809 ? 260 GLY F C   1 
ATOM 1695 O O   . GLY A 1 260 ? 9.97300   -8.14200  -23.23800 1.000 228.59906 ? 260 GLY F O   1 
ATOM 1696 N N   . SER A 1 261 ? 10.44300  -6.18500  -24.27500 1.000 244.74830 ? 261 SER F N   1 
ATOM 1697 C CA  . SER A 1 261 ? 9.71500   -5.35000  -23.32600 1.000 238.22167 ? 261 SER F CA  1 
ATOM 1698 C C   . SER A 1 261 ? 8.37000   -4.83800  -23.85100 1.000 231.30719 ? 261 SER F C   1 
ATOM 1699 O O   . SER A 1 261 ? 7.78600   -3.94200  -23.23600 1.000 224.68842 ? 261 SER F O   1 
ATOM 1700 C CB  . SER A 1 261 ? 10.58900  -4.13400  -22.93500 1.000 242.49329 ? 261 SER F CB  1 
ATOM 1701 O OG  . SER A 1 261 ? 11.03200  -3.30100  -24.02100 1.000 234.15755 ? 261 SER F OG  1 
ATOM 1702 N N   . SER A 1 262 ? 7.85700   -5.38000  -24.95600 1.000 236.23008 ? 262 SER F N   1 
ATOM 1703 C CA  . SER A 1 262 ? 6.58500   -4.93600  -25.52600 1.000 236.96603 ? 262 SER F CA  1 
ATOM 1704 C C   . SER A 1 262 ? 5.49300   -6.01000  -25.35500 1.000 239.79086 ? 262 SER F C   1 
ATOM 1705 O O   . SER A 1 262 ? 5.69600   -7.15800  -25.76900 1.000 240.15433 ? 262 SER F O   1 
ATOM 1706 C CB  . SER A 1 262 ? 6.80100   -4.62000  -27.01200 1.000 236.65675 ? 262 SER F CB  1 
ATOM 1707 O OG  . SER A 1 262 ? 7.81900   -3.63900  -27.18900 1.000 242.98677 ? 262 SER F OG  1 
ATOM 1708 N N   . VAL A 1 263 ? 4.31600   -5.64100  -24.76300 1.000 239.04067 ? 263 VAL F N   1 
ATOM 1709 C CA  . VAL A 1 263 ? 3.08700   -6.46500  -24.73900 1.000 234.15310 ? 263 VAL F CA  1 
ATOM 1710 C C   . VAL A 1 263 ? 2.16100   -6.15400  -25.91900 1.000 220.49229 ? 263 VAL F C   1 
ATOM 1711 O O   . VAL A 1 263 ? 1.80300   -4.99000  -26.13700 1.000 213.41596 ? 263 VAL F O   1 
ATOM 1712 C CB  . VAL A 1 263 ? 2.35300   -6.29500  -23.40100 1.000 235.34004 ? 263 VAL F CB  1 
ATOM 1713 C CG1 . VAL A 1 263 ? 1.07000   -7.07500  -23.41400 1.000 232.88273 ? 263 VAL F CG1 1 
ATOM 1714 C CG2 . VAL A 1 263 ? 3.23100   -6.83200  -22.28300 1.000 237.38267 ? 263 VAL F CG2 1 
ATOM 1715 N N   . ILE A 1 264 ? 1.75200   -7.17900  -26.67200 1.000 214.87682 ? 264 ILE F N   1 
ATOM 1716 C CA  . ILE A 1 264 ? 0.94400   -6.95900  -27.87100 1.000 207.30327 ? 264 ILE F CA  1 
ATOM 1717 C C   . ILE A 1 264 ? -0.41500  -7.69000  -27.91600 1.000 195.55695 ? 264 ILE F C   1 
ATOM 1718 O O   . ILE A 1 264 ? -0.43100  -8.92600  -27.92200 1.000 196.33255 ? 264 ILE F O   1 
ATOM 1719 C CB  . ILE A 1 264 ? 1.78400   -7.38400  -29.07200 1.000 209.34396 ? 264 ILE F CB  1 
ATOM 1720 C CG1 . ILE A 1 264 ? 3.04000   -6.49800  -29.12600 1.000 211.55482 ? 264 ILE F CG1 1 
ATOM 1721 C CG2 . ILE A 1 264 ? 0.94400   -7.30900  -30.29900 1.000 208.69207 ? 264 ILE F CG2 1 
ATOM 1722 C CD1 . ILE A 1 264 ? 2.76100   -5.02100  -29.18300 1.000 219.95157 ? 264 ILE F CD1 1 
ATOM 1723 N N   . TYR A 1 265 ? -1.55300  -6.97400  -28.03100 1.000 191.38628 ? 265 TYR F N   1 
ATOM 1724 C CA  . TYR A 1 265 ? -2.78800  -7.75200  -28.26900 1.000 188.24826 ? 265 TYR F CA  1 
ATOM 1725 C C   . TYR A 1 265 ? -3.66400  -7.02900  -29.28600 1.000 197.38872 ? 265 TYR F C   1 
ATOM 1726 O O   . TYR A 1 265 ? -3.43900  -5.86700  -29.61000 1.000 202.33092 ? 265 TYR F O   1 
ATOM 1727 C CB  . TYR A 1 265 ? -3.68500  -8.06000  -27.06200 1.000 181.14818 ? 265 TYR F CB  1 
ATOM 1728 C CG  . TYR A 1 265 ? -4.34200  -6.96100  -26.26100 1.000 176.16738 ? 265 TYR F CG  1 
ATOM 1729 C CD1 . TYR A 1 265 ? -5.59200  -6.46600  -26.61000 1.000 172.61135 ? 265 TYR F CD1 1 
ATOM 1730 C CD2 . TYR A 1 265 ? -3.77800  -6.50300  -25.10500 1.000 176.81834 ? 265 TYR F CD2 1 
ATOM 1731 C CE1 . TYR A 1 265 ? -6.21200  -5.51200  -25.84100 1.000 170.19312 ? 265 TYR F CE1 1 
ATOM 1732 C CE2 . TYR A 1 265 ? -4.38900  -5.56000  -24.34500 1.000 176.32914 ? 265 TYR F CE2 1 
ATOM 1733 C CZ  . TYR A 1 265 ? -5.59100  -5.07500  -24.71200 1.000 170.79909 ? 265 TYR F CZ  1 
ATOM 1734 O OH  . TYR A 1 265 ? -6.11700  -4.14000  -23.89400 1.000 180.27703 ? 265 TYR F OH  1 
ATOM 1735 N N   . MET A 1 266 ? -4.68500  -7.71500  -29.80000 1.000 203.14744 ? 266 MET F N   1 
ATOM 1736 C CA  . MET A 1 266 ? -5.59900  -7.08400  -30.75000 1.000 205.32689 ? 266 MET F CA  1 
ATOM 1737 C C   . MET A 1 266 ? -7.04800  -7.30700  -30.33300 1.000 207.79996 ? 266 MET F C   1 
ATOM 1738 O O   . MET A 1 266 ? -7.39000  -8.34100  -29.75000 1.000 209.48132 ? 266 MET F O   1 
ATOM 1739 C CB  . MET A 1 266 ? -5.41800  -7.61100  -32.14700 1.000 202.05288 ? 266 MET F CB  1 
ATOM 1740 C CG  . MET A 1 266 ? -5.47100  -9.10200  -32.15500 1.000 211.17219 ? 266 MET F CG  1 
ATOM 1741 S SD  . MET A 1 266 ? -5.58500  -9.78100  -33.80700 1.000 220.66547 ? 266 MET F SD  1 
ATOM 1742 C CE  . MET A 1 266 ? -7.28600  -9.38800  -34.21500 1.000 210.54681 ? 266 MET F CE  1 
ATOM 1743 N N   . VAL A 1 267 ? -7.90700  -6.33700  -30.62400 1.000 204.82682 ? 267 VAL F N   1 
ATOM 1744 C CA  . VAL A 1 267 ? -9.32600  -6.45400  -30.32100 1.000 196.14332 ? 267 VAL F CA  1 
ATOM 1745 C C   . VAL A 1 267 ? -10.13700 -6.33900  -31.60300 1.000 200.07140 ? 267 VAL F C   1 
ATOM 1746 O O   . VAL A 1 267 ? -10.03300 -5.32300  -32.30400 1.000 201.53589 ? 267 VAL F O   1 
ATOM 1747 C CB  . VAL A 1 267 ? -9.77600  -5.37100  -29.33200 1.000 188.61111 ? 267 VAL F CB  1 
ATOM 1748 C CG1 . VAL A 1 267 ? -11.26900 -5.41800  -29.19900 1.000 188.68694 ? 267 VAL F CG1 1 
ATOM 1749 C CG2 . VAL A 1 267 ? -9.07200  -5.53300  -27.98600 1.000 184.26206 ? 267 VAL F CG2 1 
ATOM 1750 N N   . GLN A 1 268 ? -10.92200 -7.37600  -31.92300 1.000 204.09164 ? 268 GLN F N   1 
ATOM 1751 C CA  . GLN A 1 268 ? -11.86200 -7.34900  -33.05100 1.000 208.80672 ? 268 GLN F CA  1 
ATOM 1752 C C   . GLN A 1 268 ? -13.21600 -6.80600  -32.61200 1.000 204.17029 ? 268 GLN F C   1 
ATOM 1753 O O   . GLN A 1 268 ? -13.94500 -7.45600  -31.85100 1.000 203.14717 ? 268 GLN F O   1 
ATOM 1754 C CB  . GLN A 1 268 ? -12.05000 -8.71200  -33.71400 1.000 212.72149 ? 268 GLN F CB  1 
ATOM 1755 C CG  . GLN A 1 268 ? -10.92900 -9.25800  -34.61700 1.000 216.63279 ? 268 GLN F CG  1 
ATOM 1756 C CD  . GLN A 1 268 ? -10.71700 -8.43800  -35.92200 1.000 210.69290 ? 268 GLN F CD  1 
ATOM 1757 O OE1 . GLN A 1 268 ? -10.01300 -7.42700  -35.95400 1.000 211.84475 ? 268 GLN F OE1 1 
ATOM 1758 N NE2 . GLN A 1 268 ? -11.31200 -8.92100  -37.01000 1.000 204.40784 ? 268 GLN F NE2 1 
ATOM 1759 N N   . LEU A 1 269 ? -13.55600 -5.65800  -33.12300 1.000 204.67604 ? 269 LEU F N   1 
ATOM 1760 C CA  . LEU A 1 269 ? -14.76700 -4.91300  -32.87100 1.000 203.01431 ? 269 LEU F CA  1 
ATOM 1761 C C   . LEU A 1 269 ? -15.69800 -5.03900  -34.06400 1.000 200.56745 ? 269 LEU F C   1 
ATOM 1762 O O   . LEU A 1 269 ? -15.26400 -4.86800  -35.20600 1.000 203.23066 ? 269 LEU F O   1 
ATOM 1763 C CB  . LEU A 1 269 ? -14.43200 -3.44800  -32.63200 1.000 204.32680 ? 269 LEU F CB  1 
ATOM 1764 C CG  . LEU A 1 269 ? -13.67000 -3.14800  -31.34200 1.000 200.12893 ? 269 LEU F CG  1 
ATOM 1765 C CD1 . LEU A 1 269 ? -12.71000 -1.99300  -31.55200 1.000 200.22314 ? 269 LEU F CD1 1 
ATOM 1766 C CD2 . LEU A 1 269 ? -14.64900 -2.81100  -30.29200 1.000 199.59095 ? 269 LEU F CD2 1 
ATOM 1767 N N   . PRO A 1 270 ? -16.95600 -5.40000  -33.86800 1.000 198.32793 ? 270 PRO F N   1 
ATOM 1768 C CA  . PRO A 1 270 ? -17.87500 -5.51900  -35.00600 1.000 201.57060 ? 270 PRO F CA  1 
ATOM 1769 C C   . PRO A 1 270 ? -18.20000 -4.15100  -35.58200 1.000 206.16892 ? 270 PRO F C   1 
ATOM 1770 O O   . PRO A 1 270 ? -18.49500 -3.19700  -34.85700 1.000 205.00061 ? 270 PRO F O   1 
ATOM 1771 C CB  . PRO A 1 270 ? -19.11300 -6.18400  -34.40400 1.000 203.95193 ? 270 PRO F CB  1 
ATOM 1772 C CG  . PRO A 1 270 ? -19.05800 -5.76700  -32.97500 1.000 207.28976 ? 270 PRO F CG  1 
ATOM 1773 C CD  . PRO A 1 270 ? -17.60800 -5.71600  -32.59200 1.000 201.53698 ? 270 PRO F CD  1 
ATOM 1774 N N   . ILE A 1 271 ? -18.09600 -4.04900  -36.88900 1.000 210.00428 ? 271 ILE F N   1 
ATOM 1775 C CA  . ILE A 1 271 ? -18.48000 -2.85200  -37.60700 1.000 209.04845 ? 271 ILE F CA  1 
ATOM 1776 C C   . ILE A 1 271 ? -19.90600 -3.11000  -38.07000 1.000 207.99634 ? 271 ILE F C   1 
ATOM 1777 O O   . ILE A 1 271 ? -20.16700 -4.01600  -38.88000 1.000 210.25962 ? 271 ILE F O   1 
ATOM 1778 C CB  . ILE A 1 271 ? -17.53600 -2.55000  -38.77900 1.000 210.56860 ? 271 ILE F CB  1 
ATOM 1779 C CG1 . ILE A 1 271 ? -16.08900 -2.50900  -38.29500 1.000 210.82039 ? 271 ILE F CG1 1 
ATOM 1780 C CG2 . ILE A 1 271 ? -17.88100 -1.21700  -39.40500 1.000 204.30198 ? 271 ILE F CG2 1 
ATOM 1781 C CD1 . ILE A 1 271 ? -15.08900 -2.23400  -39.38400 1.000 207.73174 ? 271 ILE F CD1 1 
ATOM 1782 N N   . PHE A 1 272 ? -20.83800 -2.40400  -37.43800 1.000 202.95054 ? 272 PHE F N   1 
ATOM 1783 C CA  . PHE A 1 272 ? -22.23700 -2.44300  -37.83800 1.000 202.30909 ? 272 PHE F CA  1 
ATOM 1784 C C   . PHE A 1 272 ? -22.41300 -1.41000  -38.93500 1.000 201.59480 ? 272 PHE F C   1 
ATOM 1785 O O   . PHE A 1 272 ? -22.94200 -0.31300  -38.74800 1.000 200.08860 ? 272 PHE F O   1 
ATOM 1786 C CB  . PHE A 1 272 ? -23.15300 -2.19300  -36.66500 1.000 204.54633 ? 272 PHE F CB  1 
ATOM 1787 C CG  . PHE A 1 272 ? -23.07400 -3.24600  -35.63400 1.000 211.15885 ? 272 PHE F CG  1 
ATOM 1788 C CD1 . PHE A 1 272 ? -23.47900 -4.53600  -35.92000 1.000 210.34421 ? 272 PHE F CD1 1 
ATOM 1789 C CD2 . PHE A 1 272 ? -22.60500 -2.95200  -34.37200 1.000 214.45726 ? 272 PHE F CD2 1 
ATOM 1790 C CE1 . PHE A 1 272 ? -23.41300 -5.52500  -34.97200 1.000 211.85696 ? 272 PHE F CE1 1 
ATOM 1791 C CE2 . PHE A 1 272 ? -22.54200 -3.92900  -33.40100 1.000 218.38199 ? 272 PHE F CE2 1 
ATOM 1792 C CZ  . PHE A 1 272 ? -22.94900 -5.22400  -33.70300 1.000 219.90093 ? 272 PHE F CZ  1 
ATOM 1793 N N   . GLY A 1 273 ? -22.03900 -1.83400  -40.12500 1.000 205.21095 ? 273 GLY F N   1 
ATOM 1794 C CA  . GLY A 1 273 ? -21.90800 -1.03400  -41.31500 1.000 205.59004 ? 273 GLY F CA  1 
ATOM 1795 C C   . GLY A 1 273 ? -23.21700 -0.80400  -41.98400 1.000 207.02005 ? 273 GLY F C   1 
ATOM 1796 O O   . GLY A 1 273 ? -23.31200 0.05100   -42.87100 1.000 205.03703 ? 273 GLY F O   1 
ATOM 1797 N N   . VAL A 1 274 ? -24.24400 -1.50900  -41.50700 1.000 208.16012 ? 274 VAL F N   1 
ATOM 1798 C CA  . VAL A 1 274 ? -25.60200 -1.39000  -42.01100 1.000 211.13386 ? 274 VAL F CA  1 
ATOM 1799 C C   . VAL A 1 274 ? -26.56200 -1.05300  -40.88300 1.000 208.31455 ? 274 VAL F C   1 
ATOM 1800 O O   . VAL A 1 274 ? -26.58700 -1.72400  -39.84200 1.000 207.61372 ? 274 VAL F O   1 
ATOM 1801 C CB  . VAL A 1 274 ? -26.06600 -2.71500  -42.64800 1.000 217.10359 ? 274 VAL F CB  1 
ATOM 1802 C CG1 . VAL A 1 274 ? -27.54800 -2.64000  -42.97500 1.000 220.21569 ? 274 VAL F CG1 1 
ATOM 1803 C CG2 . VAL A 1 274 ? -25.22900 -3.10100  -43.86600 1.000 223.71847 ? 274 VAL F CG2 1 
ATOM 1804 N N   . ILE A 1 275 ? -27.32800 0.01400   -41.09800 1.000 208.56779 ? 275 ILE F N   1 
ATOM 1805 C CA  . ILE A 1 275 ? -28.33000 0.49300   -40.16700 1.000 215.73746 ? 275 ILE F CA  1 
ATOM 1806 C C   . ILE A 1 275 ? -29.60600 0.88100   -40.91700 1.000 220.11196 ? 275 ILE F C   1 
ATOM 1807 O O   . ILE A 1 275 ? -29.56100 1.30100   -42.07900 1.000 220.09260 ? 275 ILE F O   1 
ATOM 1808 C CB  . ILE A 1 275 ? -27.80800 1.67400   -39.34100 1.000 216.92731 ? 275 ILE F CB  1 
ATOM 1809 C CG1 . ILE A 1 275 ? -27.40900 2.81500   -40.25700 1.000 215.54033 ? 275 ILE F CG1 1 
ATOM 1810 C CG2 . ILE A 1 275 ? -26.63500 1.25100   -38.50700 1.000 213.67692 ? 275 ILE F CG2 1 
ATOM 1811 C CD1 . ILE A 1 275 ? -26.95800 4.01300   -39.48100 1.000 215.18074 ? 275 ILE F CD1 1 
ATOM 1812 N N   . ASP A 1 276 ? -30.74600 0.76200   -40.20900 1.000 222.35932 ? 276 ASP F N   1 
ATOM 1813 C CA  . ASP A 1 276 ? -32.07200 1.30900   -40.57700 1.000 222.53262 ? 276 ASP F CA  1 
ATOM 1814 C C   . ASP A 1 276 ? -32.76100 0.69400   -41.78700 1.000 216.60640 ? 276 ASP F C   1 
ATOM 1815 O O   . ASP A 1 276 ? -33.56600 1.37200   -42.43700 1.000 205.42819 ? 276 ASP F O   1 
ATOM 1816 C CB  . ASP A 1 276 ? -31.92900 2.79400   -40.86200 1.000 232.33374 ? 276 ASP F CB  1 
ATOM 1817 C CG  . ASP A 1 276 ? -31.43800 3.52300   -39.67600 1.000 241.24892 ? 276 ASP F CG  1 
ATOM 1818 O OD1 . ASP A 1 276 ? -31.69700 3.02100   -38.56000 1.000 239.79879 ? 276 ASP F OD1 1 
ATOM 1819 O OD2 . ASP A 1 276 ? -30.73800 4.54100   -39.85500 1.000 250.69569 ? 276 ASP F OD2 1 
ATOM 1820 N N   . THR A 1 277 ? -32.54000 -0.57400  -42.05800 1.000 220.05463 ? 277 THR F N   1 
ATOM 1821 C CA  . THR A 1 277 ? -33.34300 -1.34700  -43.00600 1.000 223.90978 ? 277 THR F CA  1 
ATOM 1822 C C   . THR A 1 277 ? -34.46300 -2.12800  -42.30900 1.000 222.89806 ? 277 THR F C   1 
ATOM 1823 O O   . THR A 1 277 ? -34.46500 -2.25500  -41.08000 1.000 224.47094 ? 277 THR F O   1 
ATOM 1824 C CB  . THR A 1 277 ? -32.42900 -2.30800  -43.81300 1.000 229.45946 ? 277 THR F CB  1 
ATOM 1825 O OG1 . THR A 1 277 ? -31.83200 -3.29000  -42.95300 1.000 237.83128 ? 277 THR F OG1 1 
ATOM 1826 C CG2 . THR A 1 277 ? -31.31300 -1.56000  -44.59300 1.000 222.81189 ? 277 THR F CG2 1 
ATOM 1827 N N   . PRO A 1 278 ? -35.52300 -2.51100  -43.04200 1.000 220.44175 ? 278 PRO F N   1 
ATOM 1828 C CA  . PRO A 1 278 ? -36.66800 -3.14700  -42.38800 1.000 215.20739 ? 278 PRO F CA  1 
ATOM 1829 C C   . PRO A 1 278 ? -36.25900 -4.47000  -41.77600 1.000 219.10102 ? 278 PRO F C   1 
ATOM 1830 O O   . PRO A 1 278 ? -35.63600 -5.31300  -42.43000 1.000 225.16453 ? 278 PRO F O   1 
ATOM 1831 C CB  . PRO A 1 278 ? -37.64400 -3.39700  -43.54000 1.000 210.07400 ? 278 PRO F CB  1 
ATOM 1832 C CG  . PRO A 1 278 ? -37.30200 -2.45900  -44.55100 1.000 216.88712 ? 278 PRO F CG  1 
ATOM 1833 C CD  . PRO A 1 278 ? -35.80100 -2.30200  -44.47200 1.000 223.53211 ? 278 PRO F CD  1 
ATOM 1834 N N   . CYS A 1 279 ? -36.65200 -4.67800  -40.54100 1.000 214.92858 ? 279 CYS F N   1 
ATOM 1835 C CA  . CYS A 1 279 ? -36.57400 -5.99500  -39.96100 1.000 213.12345 ? 279 CYS F CA  1 
ATOM 1836 C C   . CYS A 1 279 ? -37.93800 -6.22700  -39.34500 1.000 206.88320 ? 279 CYS F C   1 
ATOM 1837 O O   . CYS A 1 279 ? -38.69000 -5.28900  -39.07700 1.000 206.46365 ? 279 CYS F O   1 
ATOM 1838 C CB  . CYS A 1 279 ? -35.39700 -6.15800  -38.97000 1.000 217.07086 ? 279 CYS F CB  1 
ATOM 1839 S SG  . CYS A 1 279 ? -33.69500 -5.94300  -39.70800 1.000 217.86648 ? 279 CYS F SG  1 
ATOM 1840 N N   . TRP A 1 280 ? -38.26600 -7.48300  -39.14500 1.000 207.15922 ? 280 TRP F N   1 
ATOM 1841 C CA  . TRP A 1 280 ? -39.50300 -7.78200  -38.46400 1.000 209.66871 ? 280 TRP F CA  1 
ATOM 1842 C C   . TRP A 1 280 ? -39.30800 -9.12700  -37.81900 1.000 210.92524 ? 280 TRP F C   1 
ATOM 1843 O O   . TRP A 1 280 ? -38.48200 -9.92600  -38.26500 1.000 217.11730 ? 280 TRP F O   1 
ATOM 1844 C CB  . TRP A 1 280 ? -40.67400 -7.81300  -39.42500 1.000 220.78739 ? 280 TRP F CB  1 
ATOM 1845 C CG  . TRP A 1 280 ? -40.54600 -8.84800  -40.49900 1.000 230.52143 ? 280 TRP F CG  1 
ATOM 1846 C CD1 . TRP A 1 280 ? -40.98700 -10.14100 -40.45300 1.000 234.69466 ? 280 TRP F CD1 1 
ATOM 1847 C CD2 . TRP A 1 280 ? -39.94600 -8.67800  -41.78600 1.000 238.81135 ? 280 TRP F CD2 1 
ATOM 1848 N NE1 . TRP A 1 280 ? -40.71100 -10.78500 -41.64000 1.000 242.10355 ? 280 TRP F NE1 1 
ATOM 1849 C CE2 . TRP A 1 280 ? -40.07200 -9.90900  -42.47700 1.000 246.78697 ? 280 TRP F CE2 1 
ATOM 1850 C CE3 . TRP A 1 280 ? -39.32000 -7.60500  -42.42800 1.000 238.52286 ? 280 TRP F CE3 1 
ATOM 1851 C CZ2 . TRP A 1 280 ? -39.58500 -10.09500 -43.77700 1.000 255.97296 ? 280 TRP F CZ2 1 
ATOM 1852 C CZ3 . TRP A 1 280 ? -38.84100 -7.79100  -43.72200 1.000 246.08534 ? 280 TRP F CZ3 1 
ATOM 1853 C CH2 . TRP A 1 280 ? -38.97500 -9.02800  -44.38000 1.000 254.89060 ? 280 TRP F CH2 1 
ATOM 1854 N N   . ILE A 1 281 ? -40.05500 -9.38900  -36.76600 1.000 207.90313 ? 281 ILE F N   1 
ATOM 1855 C CA  . ILE A 1 281 ? -39.84800 -10.65400 -36.08100 1.000 215.27755 ? 281 ILE F CA  1 
ATOM 1856 C C   . ILE A 1 281 ? -41.14100 -11.46200 -35.98000 1.000 218.05235 ? 281 ILE F C   1 
ATOM 1857 O O   . ILE A 1 281 ? -42.21400 -10.91700 -35.68100 1.000 214.39689 ? 281 ILE F O   1 
ATOM 1858 C CB  . ILE A 1 281 ? -39.12300 -10.39800 -34.75700 1.000 215.03790 ? 281 ILE F CB  1 
ATOM 1859 C CG1 . ILE A 1 281 ? -38.91800 -11.70600 -34.02300 1.000 224.87736 ? 281 ILE F CG1 1 
ATOM 1860 C CG2 . ILE A 1 281 ? -39.83300 -9.32800  -33.99200 1.000 218.60387 ? 281 ILE F CG2 1 
ATOM 1861 C CD1 . ILE A 1 281 ? -37.96300 -11.57600 -32.89300 1.000 223.48373 ? 281 ILE F CD1 1 
ATOM 1862 N N   . VAL A 1 282 ? -41.00500 -12.78600 -36.13900 1.000 221.29359 ? 282 VAL F N   1 
ATOM 1863 C CA  . VAL A 1 282 ? -42.12800 -13.72000 -36.11000 1.000 221.42988 ? 282 VAL F CA  1 
ATOM 1864 C C   . VAL A 1 282 ? -42.10400 -14.68900 -34.93400 1.000 232.19334 ? 282 VAL F C   1 
ATOM 1865 O O   . VAL A 1 282 ? -41.14300 -15.45400 -34.77500 1.000 233.39196 ? 282 VAL F O   1 
ATOM 1866 C CB  . VAL A 1 282 ? -42.10300 -14.55700 -37.39900 1.000 219.71968 ? 282 VAL F CB  1 
ATOM 1867 C CG1 . VAL A 1 282 ? -43.10300 -15.70900 -37.33900 1.000 225.94782 ? 282 VAL F CG1 1 
ATOM 1868 C CG2 . VAL A 1 282 ? -42.24400 -13.68900 -38.63000 1.000 217.24278 ? 282 VAL F CG2 1 
ATOM 1869 N N   . LYS A 1 283 ? -43.19400 -14.68200 -34.14500 1.000 239.74322 ? 283 LYS F N   1 
ATOM 1870 C CA  . LYS A 1 283 ? -43.55000 -15.63500 -33.08400 1.000 248.38540 ? 283 LYS F CA  1 
ATOM 1871 C C   . LYS A 1 283 ? -44.80200 -16.44100 -33.39900 1.000 251.12472 ? 283 LYS F C   1 
ATOM 1872 O O   . LYS A 1 283 ? -45.71000 -15.99600 -34.10400 1.000 255.40431 ? 283 LYS F O   1 
ATOM 1873 C CB  . LYS A 1 283 ? -43.67900 -15.00300 -31.69100 1.000 253.30939 ? 283 LYS F CB  1 
ATOM 1874 C CG  . LYS A 1 283 ? -42.38300 -14.53500 -31.09400 1.000 258.48214 ? 283 LYS F CG  1 
ATOM 1875 C CD  . LYS A 1 283 ? -41.50100 -15.82500 -30.95600 1.000 255.40933 ? 283 LYS F CD  1 
ATOM 1876 C CE  . LYS A 1 283 ? -40.03100 -15.75700 -31.39500 1.000 251.47317 ? 283 LYS F CE  1 
ATOM 1877 N NZ  . LYS A 1 283 ? -39.81500 -15.71700 -32.87700 1.000 242.93716 ? 283 LYS F NZ  1 
ATOM 1878 N N   . ALA A 1 284 ? -44.88200 -17.60000 -32.76000 1.000 251.34069 ? 284 ALA F N   1 
ATOM 1879 C CA  . ALA A 1 284 ? -45.97900 -18.51400 -32.99400 1.000 254.26700 ? 284 ALA F CA  1 
ATOM 1880 C C   . ALA A 1 284 ? -46.17800 -19.35700 -31.75200 1.000 255.22181 ? 284 ALA F C   1 
ATOM 1881 O O   . ALA A 1 284 ? -45.26500 -19.53800 -30.94000 1.000 254.83654 ? 284 ALA F O   1 
ATOM 1882 C CB  . ALA A 1 284 ? -45.72200 -19.40000 -34.21700 1.000 262.05773 ? 284 ALA F CB  1 
ATOM 1883 N N   . ALA A 1 285 ? -47.38200 -19.89000 -31.63600 1.000 257.26466 ? 285 ALA F N   1 
ATOM 1884 C CA  . ALA A 1 285 ? -47.73600 -20.76000 -30.53200 1.000 259.25504 ? 285 ALA F CA  1 
ATOM 1885 C C   . ALA A 1 285 ? -48.56100 -21.91900 -31.07000 1.000 261.34263 ? 285 ALA F C   1 
ATOM 1886 O O   . ALA A 1 285 ? -49.12500 -21.84400 -32.16600 1.000 263.48131 ? 285 ALA F O   1 
ATOM 1887 C CB  . ALA A 1 285 ? -48.52600 -19.98100 -29.46800 1.000 257.62848 ? 285 ALA F CB  1 
ATOM 1888 N N   . PRO A 1 286 ? -48.60200 -23.02200 -30.33700 1.000 259.88828 ? 286 PRO F N   1 
ATOM 1889 C CA  . PRO A 1 286 ? -49.29700 -24.23300 -30.80000 1.000 268.68998 ? 286 PRO F CA  1 
ATOM 1890 C C   . PRO A 1 286 ? -50.79300 -24.07100 -31.05500 1.000 267.17025 ? 286 PRO F C   1 
ATOM 1891 O O   . PRO A 1 286 ? -51.53000 -23.51800 -30.23100 1.000 263.05936 ? 286 PRO F O   1 
ATOM 1892 C CB  . PRO A 1 286 ? -49.02100 -25.23100 -29.67200 1.000 277.61583 ? 286 PRO F CB  1 
ATOM 1893 C CG  . PRO A 1 286 ? -47.71700 -24.77000 -29.08600 1.000 266.08915 ? 286 PRO F CG  1 
ATOM 1894 C CD  . PRO A 1 286 ? -47.76000 -23.27800 -29.15700 1.000 258.06212 ? 286 PRO F CD  1 
ATOM 1895 N N   . SER A 1 287 ? -51.22300 -24.45500 -32.25600 1.000 268.81581 ? 287 SER F N   1 
ATOM 1896 C CA  . SER A 1 287 ? -52.64700 -24.48900 -32.57900 1.000 278.80681 ? 287 SER F CA  1 
ATOM 1897 C C   . SER A 1 287 ? -53.16000 -25.93900 -32.42200 1.000 291.88763 ? 287 SER F C   1 
ATOM 1898 O O   . SER A 1 287 ? -52.79200 -26.82200 -33.21600 1.000 296.37280 ? 287 SER F O   1 
ATOM 1899 C CB  . SER A 1 287 ? -52.90400 -23.90600 -33.96200 1.000 281.16737 ? 287 SER F CB  1 
ATOM 1900 O OG  . SER A 1 287 ? -54.29000 -23.93500 -34.26300 1.000 285.06558 ? 287 SER F OG  1 
ATOM 1901 N N   . CYS A 1 288 ? -53.97300 -26.18500 -31.37400 1.000 295.62709 ? 288 CYS F N   1 
ATOM 1902 C CA  . CYS A 1 288 ? -54.51100 -27.50000 -30.97100 1.000 299.22696 ? 288 CYS F CA  1 
ATOM 1903 C C   . CYS A 1 288 ? -56.02700 -27.56500 -31.05600 1.000 291.05945 ? 288 CYS F C   1 
ATOM 1904 O O   . CYS A 1 288 ? -56.73400 -26.67800 -30.56200 1.000 280.67883 ? 288 CYS F O   1 
ATOM 1905 C CB  . CYS A 1 288 ? -54.12700 -28.00100 -29.56200 1.000 299.41335 ? 288 CYS F CB  1 
ATOM 1906 S SG  . CYS A 1 288 ? -52.44300 -28.63200 -29.26500 1.000 320.56551 ? 288 CYS F SG  1 
ATOM 1907 N N   . SER A 1 289 ? -56.50500 -28.66800 -31.62500 1.000 291.89924 ? 289 SER F N   1 
ATOM 1908 C CA  . SER A 1 289 ? -57.91400 -28.99000 -31.71600 1.000 285.12886 ? 289 SER F CA  1 
ATOM 1909 C C   . SER A 1 289 ? -58.19500 -30.30000 -31.00800 1.000 286.96345 ? 289 SER F C   1 
ATOM 1910 O O   . SER A 1 289 ? -57.44100 -31.26700 -31.15000 1.000 290.94636 ? 289 SER F O   1 
ATOM 1911 C CB  . SER A 1 289 ? -58.31600 -29.14100 -33.16700 1.000 285.22509 ? 289 SER F CB  1 
ATOM 1912 O OG  . SER A 1 289 ? -58.04000 -27.96000 -33.86500 1.000 304.38924 ? 289 SER F OG  1 
ATOM 1913 N N   . GLU A 1 290 ? -59.32500 -30.36100 -30.30600 1.000 288.36767 ? 290 GLU F N   1 
ATOM 1914 C CA  . GLU A 1 290 ? -59.65100 -31.53400 -29.51300 1.000 299.97953 ? 290 GLU F CA  1 
ATOM 1915 C C   . GLU A 1 290 ? -60.97000 -32.06500 -30.00400 1.000 304.35001 ? 290 GLU F C   1 
ATOM 1916 O O   . GLU A 1 290 ? -61.92600 -31.32000 -30.24500 1.000 308.71189 ? 290 GLU F O   1 
ATOM 1917 C CB  . GLU A 1 290 ? -59.84000 -31.20400 -27.99000 1.000 304.16846 ? 290 GLU F CB  1 
ATOM 1918 C CG  . GLU A 1 290 ? -60.59000 -32.31300 -27.10000 1.000 308.28875 ? 290 GLU F CG  1 
ATOM 1919 C CD  . GLU A 1 290 ? -62.12600 -32.07700 -26.84400 1.000 304.36052 ? 290 GLU F CD  1 
ATOM 1920 O OE1 . GLU A 1 290 ? -62.59200 -30.91800 -26.84900 1.000 298.40942 ? 290 GLU F OE1 1 
ATOM 1921 O OE2 . GLU A 1 290 ? -62.87700 -33.05900 -26.61800 1.000 303.12928 ? 290 GLU F OE2 1 
ATOM 1922 N N   . LYS A 1 291 ? -60.97900 -33.37900 -30.14000 1.000 306.11400 ? 291 LYS F N   1 
ATOM 1923 C CA  . LYS A 1 291 ? -62.14900 -34.15200 -30.48500 1.000 311.17763 ? 291 LYS F CA  1 
ATOM 1924 C C   . LYS A 1 291 ? -62.15800 -35.40000 -29.62400 1.000 318.78929 ? 291 LYS F C   1 
ATOM 1925 O O   . LYS A 1 291 ? -61.17800 -36.15800 -29.62900 1.000 316.33307 ? 291 LYS F O   1 
ATOM 1926 C CB  . LYS A 1 291 ? -62.13700 -34.48000 -31.98500 1.000 311.10960 ? 291 LYS F CB  1 
ATOM 1927 C CG  . LYS A 1 291 ? -62.14200 -33.22300 -32.85500 1.000 307.83718 ? 291 LYS F CG  1 
ATOM 1928 C CD  . LYS A 1 291 ? -61.16600 -33.29700 -33.99700 1.000 311.14533 ? 291 LYS F CD  1 
ATOM 1929 C CE  . LYS A 1 291 ? -59.78700 -32.98100 -33.50900 1.000 303.32157 ? 291 LYS F CE  1 
ATOM 1930 N NZ  . LYS A 1 291 ? -59.84400 -31.68400 -32.87600 1.000 301.82839 ? 291 LYS F NZ  1 
ATOM 1931 N N   . LYS A 1 292 ? -63.23300 -35.57500 -28.85500 1.000 326.16338 ? 292 LYS F N   1 
ATOM 1932 C CA  . LYS A 1 292 ? -63.44200 -36.77800 -28.05700 1.000 330.61802 ? 292 LYS F CA  1 
ATOM 1933 C C   . LYS A 1 292 ? -62.30500 -37.00500 -27.06500 1.000 324.34928 ? 292 LYS F C   1 
ATOM 1934 O O   . LYS A 1 292 ? -61.86800 -38.14000 -26.84300 1.000 321.99942 ? 292 LYS F O   1 
ATOM 1935 C CB  . LYS A 1 292 ? -63.55800 -37.97300 -29.00400 1.000 333.35249 ? 292 LYS F CB  1 
ATOM 1936 C CG  . LYS A 1 292 ? -64.71400 -37.87200 -30.00600 1.000 338.69611 ? 292 LYS F CG  1 
ATOM 1937 C CD  . LYS A 1 292 ? -64.69200 -39.01800 -31.02500 1.000 337.20948 ? 292 LYS F CD  1 
ATOM 1938 C CE  . LYS A 1 292 ? -63.40800 -39.05600 -31.86500 1.000 321.56210 ? 292 LYS F CE  1 
ATOM 1939 N NZ  . LYS A 1 292 ? -63.25000 -37.85200 -32.71800 1.000 320.30768 ? 292 LYS F NZ  1 
ATOM 1940 N N   . GLY A 1 293 ? -61.79300 -35.92800 -26.48000 1.000 321.61357 ? 293 GLY F N   1 
ATOM 1941 C CA  . GLY A 1 293 ? -60.77400 -36.11400 -25.47700 1.000 316.61174 ? 293 GLY F CA  1 
ATOM 1942 C C   . GLY A 1 293 ? -59.40300 -36.34700 -26.07000 1.000 314.54352 ? 293 GLY F C   1 
ATOM 1943 O O   . GLY A 1 293 ? -58.45400 -36.60700 -25.31800 1.000 314.55283 ? 293 GLY F O   1 
ATOM 1944 N N   . ASN A 1 294 ? -59.29900 -36.36400 -27.40000 1.000 315.65111 ? 294 ASN F N   1 
ATOM 1945 C CA  . ASN A 1 294 ? -58.06200 -36.54800 -28.14300 1.000 316.26565 ? 294 ASN F CA  1 
ATOM 1946 C C   . ASN A 1 294 ? -57.65600 -35.27900 -28.89800 1.000 312.34025 ? 294 ASN F C   1 
ATOM 1947 O O   . ASN A 1 294 ? -58.51100 -34.49400 -29.31300 1.000 311.72391 ? 294 ASN F O   1 
ATOM 1948 C CB  . ASN A 1 294 ? -58.26000 -37.70100 -29.12600 1.000 319.75586 ? 294 ASN F CB  1 
ATOM 1949 C CG  . ASN A 1 294 ? -58.44200 -39.03400 -28.42200 1.000 320.26868 ? 294 ASN F CG  1 
ATOM 1950 O OD1 . ASN A 1 294 ? -58.00200 -39.22700 -27.28100 1.000 321.45888 ? 294 ASN F OD1 1 
ATOM 1951 N ND2 . ASN A 1 294 ? -59.12600 -39.95500 -29.09200 1.000 316.93873 ? 294 ASN F ND2 1 
ATOM 1952 N N   . TYR A 1 295 ? -56.34700 -35.07200 -29.09500 1.000 306.23002 ? 295 TYR F N   1 
ATOM 1953 C CA  . TYR A 1 295 ? -55.83600 -33.82800 -29.67200 1.000 305.12484 ? 295 TYR F CA  1 
ATOM 1954 C C   . TYR A 1 295 ? -55.11800 -34.07800 -30.99700 1.000 309.44173 ? 295 TYR F C   1 
ATOM 1955 O O   . TYR A 1 295 ? -54.39600 -35.06900 -31.14100 1.000 302.71583 ? 295 TYR F O   1 
ATOM 1956 C CB  . TYR A 1 295 ? -54.89100 -33.09600 -28.69600 1.000 300.09680 ? 295 TYR F CB  1 
ATOM 1957 C CG  . TYR A 1 295 ? -55.57700 -32.30400 -27.60300 1.000 301.11764 ? 295 TYR F CG  1 
ATOM 1958 C CD1 . TYR A 1 295 ? -55.98200 -30.99400 -27.84800 1.000 298.42529 ? 295 TYR F CD1 1 
ATOM 1959 C CD2 . TYR A 1 295 ? -55.86200 -32.85100 -26.36400 1.000 303.11055 ? 295 TYR F CD2 1 
ATOM 1960 C CE1 . TYR A 1 295 ? -56.61200 -30.23900 -26.89200 1.000 291.10389 ? 295 TYR F CE1 1 
ATOM 1961 C CE2 . TYR A 1 295 ? -56.49500 -32.09000 -25.38300 1.000 301.80561 ? 295 TYR F CE2 1 
ATOM 1962 C CZ  . TYR A 1 295 ? -56.87200 -30.78600 -25.66400 1.000 294.01602 ? 295 TYR F CZ  1 
ATOM 1963 O OH  . TYR A 1 295 ? -57.50600 -30.00500 -24.72900 1.000 289.77775 ? 295 TYR F OH  1 
ATOM 1964 N N   . ALA A 1 296 ? -55.30600 -33.14600 -31.95100 1.000 314.30473 ? 296 ALA F N   1 
ATOM 1965 C CA  . ALA A 1 296 ? -54.48200 -32.97600 -33.15600 1.000 310.49662 ? 296 ALA F CA  1 
ATOM 1966 C C   . ALA A 1 296 ? -53.88700 -31.57000 -33.13800 1.000 302.43157 ? 296 ALA F C   1 
ATOM 1967 O O   . ALA A 1 296 ? -54.63200 -30.57800 -33.09100 1.000 302.24014 ? 296 ALA F O   1 
ATOM 1968 C CB  . ALA A 1 296 ? -55.29800 -33.20200 -34.43000 1.000 311.14372 ? 296 ALA F CB  1 
ATOM 1969 N N   . CYS A 1 297 ? -52.55200 -31.47500 -33.18700 1.000 295.42028 ? 297 CYS F N   1 
ATOM 1970 C CA  . CYS A 1 297 ? -51.90700 -30.18300 -33.01500 1.000 295.06048 ? 297 CYS F CA  1 
ATOM 1971 C C   . CYS A 1 297 ? -50.91600 -29.87500 -34.11800 1.000 290.14837 ? 297 CYS F C   1 
ATOM 1972 O O   . CYS A 1 297 ? -50.25000 -30.78200 -34.62800 1.000 287.75030 ? 297 CYS F O   1 
ATOM 1973 C CB  . CYS A 1 297 ? -51.18900 -30.16000 -31.66800 1.000 302.47285 ? 297 CYS F CB  1 
ATOM 1974 S SG  . CYS A 1 297 ? -52.34900 -30.40600 -30.27800 1.000 323.89782 ? 297 CYS F SG  1 
ATOM 1975 N N   . LEU A 1 298 ? -50.80500 -28.59000 -34.48600 1.000 292.77242 ? 298 LEU F N   1 
ATOM 1976 C CA  . LEU A 1 298 ? -49.68600 -28.25000 -35.35500 1.000 295.18728 ? 298 LEU F CA  1 
ATOM 1977 C C   . LEU A 1 298 ? -49.03400 -26.93000 -34.94500 1.000 288.26492 ? 298 LEU F C   1 
ATOM 1978 O O   . LEU A 1 298 ? -49.66000 -26.05800 -34.32000 1.000 283.95109 ? 298 LEU F O   1 
ATOM 1979 C CB  . LEU A 1 298 ? -50.13700 -28.11400 -36.80300 1.000 304.07056 ? 298 LEU F CB  1 
ATOM 1980 C CG  . LEU A 1 298 ? -50.64200 -29.36600 -37.51100 1.000 309.41888 ? 298 LEU F CG  1 
ATOM 1981 C CD1 . LEU A 1 298 ? -52.12200 -29.63700 -37.14100 1.000 313.37739 ? 298 LEU F CD1 1 
ATOM 1982 C CD2 . LEU A 1 298 ? -50.37300 -29.31000 -39.01500 1.000 322.99225 ? 298 LEU F CD2 1 
ATOM 1983 N N   . LEU A 1 299 ? -47.76000 -26.78300 -35.35900 1.000 284.30877 ? 299 LEU F N   1 
ATOM 1984 C CA  . LEU A 1 299 ? -46.97100 -25.59600 -35.02200 1.000 278.50374 ? 299 LEU F CA  1 
ATOM 1985 C C   . LEU A 1 299 ? -45.98600 -25.12900 -36.09000 1.000 279.74894 ? 299 LEU F C   1 
ATOM 1986 O O   . LEU A 1 299 ? -45.21300 -25.93600 -36.63100 1.000 292.41173 ? 299 LEU F O   1 
ATOM 1987 C CB  . LEU A 1 299 ? -46.17100 -25.78500 -33.73300 1.000 281.21055 ? 299 LEU F CB  1 
ATOM 1988 C CG  . LEU A 1 299 ? -45.17700 -24.61900 -33.56300 1.000 279.42533 ? 299 LEU F CG  1 
ATOM 1989 C CD1 . LEU A 1 299 ? -45.90300 -23.29300 -33.31500 1.000 269.36579 ? 299 LEU F CD1 1 
ATOM 1990 C CD2 . LEU A 1 299 ? -44.07300 -24.84300 -32.54500 1.000 287.73214 ? 299 LEU F CD2 1 
ATOM 1991 N N   . ARG A 1 300 ? -46.09800 -23.85400 -36.45700 1.000 277.42254 ? 300 ARG F N   1 
ATOM 1992 C CA  . ARG A 1 300 ? -45.16500 -23.19400 -37.36800 1.000 284.01930 ? 300 ARG F CA  1 
ATOM 1993 C C   . ARG A 1 300 ? -43.76700 -23.14500 -36.74800 1.000 276.61152 ? 300 ARG F C   1 
ATOM 1994 O O   . ARG A 1 300 ? -43.60000 -22.79300 -35.57700 1.000 266.90633 ? 300 ARG F O   1 
ATOM 1995 C CB  . ARG A 1 300 ? -45.67100 -21.80800 -37.73500 1.000 284.50226 ? 300 ARG F CB  1 
ATOM 1996 C CG  . ARG A 1 300 ? -46.79700 -21.97100 -38.72600 1.000 290.25172 ? 300 ARG F CG  1 
ATOM 1997 C CD  . ARG A 1 300 ? -47.35500 -20.69900 -39.24900 1.000 287.01968 ? 300 ARG F CD  1 
ATOM 1998 N NE  . ARG A 1 300 ? -46.44900 -19.98100 -40.12200 1.000 282.19578 ? 300 ARG F NE  1 
ATOM 1999 C CZ  . ARG A 1 300 ? -46.76000 -18.82100 -40.67300 1.000 289.79781 ? 300 ARG F CZ  1 
ATOM 2000 N NH1 . ARG A 1 300 ? -47.93000 -18.24400 -40.44900 1.000 289.54856 ? 300 ARG F NH1 1 
ATOM 2001 N NH2 . ARG A 1 300 ? -45.88500 -18.23000 -41.47400 1.000 297.89921 ? 300 ARG F NH2 1 
ATOM 2002 N N   . GLU A 1 301 ? -42.76800 -23.47800 -37.55300 1.000 280.66208 ? 301 GLU F N   1 
ATOM 2003 C CA  . GLU A 1 301 ? -41.35100 -23.52900 -37.20200 1.000 274.93892 ? 301 GLU F CA  1 
ATOM 2004 C C   . GLU A 1 301 ? -40.56300 -22.42400 -37.88300 1.000 266.73880 ? 301 GLU F C   1 
ATOM 2005 O O   . GLU A 1 301 ? -39.33400 -22.48700 -37.96500 1.000 260.80115 ? 301 GLU F O   1 
ATOM 2006 C CB  . GLU A 1 301 ? -40.73000 -24.87900 -37.56900 1.000 287.18807 ? 301 GLU F CB  1 
ATOM 2007 C CG  . GLU A 1 301 ? -41.22100 -26.04900 -36.77700 1.000 299.09373 ? 301 GLU F CG  1 
ATOM 2008 C CD  . GLU A 1 301 ? -40.61800 -26.03700 -35.38300 1.000 301.99220 ? 301 GLU F CD  1 
ATOM 2009 O OE1 . GLU A 1 301 ? -39.38500 -25.87000 -35.27500 1.000 309.47470 ? 301 GLU F OE1 1 
ATOM 2010 O OE2 . GLU A 1 301 ? -41.36800 -26.18700 -34.39700 1.000 301.11743 ? 301 GLU F OE2 1 
ATOM 2011 N N   . ASP A 1 302 ? -41.22400 -21.33300 -38.21700 1.000 266.36964 ? 302 ASP F N   1 
ATOM 2012 C CA  . ASP A 1 302 ? -40.53600 -20.20600 -38.82100 1.000 263.83592 ? 302 ASP F CA  1 
ATOM 2013 C C   . ASP A 1 302 ? -40.35000 -19.00200 -37.90300 1.000 253.61756 ? 302 ASP F C   1 
ATOM 2014 O O   . ASP A 1 302 ? -40.15100 -17.87200 -38.36200 1.000 249.21883 ? 302 ASP F O   1 
ATOM 2015 C CB  . ASP A 1 302 ? -41.33900 -19.87300 -40.08300 1.000 274.01672 ? 302 ASP F CB  1 
ATOM 2016 C CG  . ASP A 1 302 ? -42.83900 -19.57800 -39.78700 1.000 272.99076 ? 302 ASP F CG  1 
ATOM 2017 O OD1 . ASP A 1 302 ? -43.14700 -18.89600 -38.78700 1.000 269.63644 ? 302 ASP F OD1 1 
ATOM 2018 O OD2 . ASP A 1 302 ? -43.71600 -20.10700 -40.53000 1.000 273.57771 ? 302 ASP F OD2 1 
ATOM 2019 N N   . GLN A 1 303 ? -40.30000 -19.27000 -36.60200 1.000 253.30528 ? 303 GLN F N   1 
ATOM 2020 C CA  . GLN A 1 303 ? -40.06500 -18.24000 -35.60600 1.000 249.70894 ? 303 GLN F CA  1 
ATOM 2021 C C   . GLN A 1 303 ? -38.62900 -17.72600 -35.74500 1.000 245.64820 ? 303 GLN F C   1 
ATOM 2022 O O   . GLN A 1 303 ? -37.72500 -18.45800 -36.16900 1.000 246.20843 ? 303 GLN F O   1 
ATOM 2023 C CB  . GLN A 1 303 ? -40.36600 -18.78200 -34.19900 1.000 256.88809 ? 303 GLN F CB  1 
ATOM 2024 C CG  . GLN A 1 303 ? -41.82100 -19.35700 -34.05900 1.000 258.79577 ? 303 GLN F CG  1 
ATOM 2025 C CD  . GLN A 1 303 ? -42.19600 -19.88500 -32.65600 1.000 263.95107 ? 303 GLN F CD  1 
ATOM 2026 O OE1 . GLN A 1 303 ? -41.70800 -19.39700 -31.63200 1.000 263.65407 ? 303 GLN F OE1 1 
ATOM 2027 N NE2 . GLN A 1 303 ? -43.04100 -20.91300 -32.62100 1.000 266.97327 ? 303 GLN F NE2 1 
ATOM 2028 N N   . GLY A 1 304 ? -38.40500 -16.47900 -35.31500 1.000 242.19512 ? 304 GLY F N   1 
ATOM 2029 C CA  . GLY A 1 304 ? -37.08900 -15.86200 -35.34400 1.000 243.03640 ? 304 GLY F CA  1 
ATOM 2030 C C   . GLY A 1 304 ? -37.10900 -14.52900 -36.08600 1.000 236.64612 ? 304 GLY F C   1 
ATOM 2031 O O   . GLY A 1 304 ? -38.17600 -13.92700 -36.30200 1.000 235.77321 ? 304 GLY F O   1 
ATOM 2032 N N   . TRP A 1 305 ? -35.89800 -14.02900 -36.43900 1.000 233.85553 ? 305 TRP F N   1 
ATOM 2033 C CA  . TRP A 1 305 ? -35.70700 -12.69600 -37.03100 1.000 230.47142 ? 305 TRP F CA  1 
ATOM 2034 C C   . TRP A 1 305 ? -35.63900 -12.70400 -38.57200 1.000 230.43482 ? 305 TRP F C   1 
ATOM 2035 O O   . TRP A 1 305 ? -35.04600 -13.61200 -39.16700 1.000 226.98227 ? 305 TRP F O   1 
ATOM 2036 C CB  . TRP A 1 305 ? -34.42100 -12.08000 -36.47000 1.000 227.82190 ? 305 TRP F CB  1 
ATOM 2037 C CG  . TRP A 1 305 ? -34.55500 -11.46500 -35.08900 1.000 222.35334 ? 305 TRP F CG  1 
ATOM 2038 C CD1 . TRP A 1 305 ? -34.12500 -12.01500 -33.92400 1.000 217.80898 ? 305 TRP F CD1 1 
ATOM 2039 C CD2 . TRP A 1 305 ? -35.18000 -10.21000 -34.73800 1.000 219.96388 ? 305 TRP F CD2 1 
ATOM 2040 N NE1 . TRP A 1 305 ? -34.41500 -11.17800 -32.87900 1.000 219.65566 ? 305 TRP F NE1 1 
ATOM 2041 C CE2 . TRP A 1 305 ? -35.06100 -10.06400 -33.35400 1.000 213.14023 ? 305 TRP F CE2 1 
ATOM 2042 C CE3 . TRP A 1 305 ? -35.81500 -9.19700  -35.46500 1.000 218.81664 ? 305 TRP F CE3 1 
ATOM 2043 C CZ2 . TRP A 1 305 ? -35.55400 -8.95300  -32.68200 1.000 216.23905 ? 305 TRP F CZ2 1 
ATOM 2044 C CZ3 . TRP A 1 305 ? -36.30200 -8.10100  -34.78900 1.000 210.89718 ? 305 TRP F CZ3 1 
ATOM 2045 C CH2 . TRP A 1 305 ? -36.16800 -7.98800  -33.41900 1.000 214.67043 ? 305 TRP F CH2 1 
ATOM 2046 N N   . TYR A 1 306 ? -36.18000 -11.64100 -39.21900 1.000 231.25886 ? 306 TYR F N   1 
ATOM 2047 C CA  . TYR A 1 306 ? -36.10200 -11.45100 -40.67400 1.000 229.08577 ? 306 TYR F CA  1 
ATOM 2048 C C   . TYR A 1 306 ? -35.62900 -10.02000 -40.99200 1.000 228.82357 ? 306 TYR F C   1 
ATOM 2049 O O   . TYR A 1 306 ? -36.14300 -9.05800  -40.40400 1.000 225.70344 ? 306 TYR F O   1 
ATOM 2050 C CB  . TYR A 1 306 ? -37.48500 -11.72500 -41.32500 1.000 231.86055 ? 306 TYR F CB  1 
ATOM 2051 C CG  . TYR A 1 306 ? -38.05600 -13.14900 -41.12100 1.000 228.77321 ? 306 TYR F CG  1 
ATOM 2052 C CD1 . TYR A 1 306 ? -38.67700 -13.49000 -39.92400 1.000 228.97806 ? 306 TYR F CD1 1 
ATOM 2053 C CD2 . TYR A 1 306 ? -37.95000 -14.14200 -42.08500 1.000 229.18593 ? 306 TYR F CD2 1 
ATOM 2054 C CE1 . TYR A 1 306 ? -39.18400 -14.74700 -39.69700 1.000 227.82338 ? 306 TYR F CE1 1 
ATOM 2055 C CE2 . TYR A 1 306 ? -38.46600 -15.41800 -41.85200 1.000 228.16872 ? 306 TYR F CE2 1 
ATOM 2056 C CZ  . TYR A 1 306 ? -39.07400 -15.69900 -40.65600 1.000 226.73233 ? 306 TYR F CZ  1 
ATOM 2057 O OH  . TYR A 1 306 ? -39.58500 -16.93800 -40.40600 1.000 236.60825 ? 306 TYR F OH  1 
ATOM 2058 N N   . CYS A 1 307 ? -34.68000 -9.86600  -41.93400 1.000 228.31750 ? 307 CYS F N   1 
ATOM 2059 C CA  . CYS A 1 307 ? -34.21000 -8.53700  -42.35500 1.000 230.31550 ? 307 CYS F CA  1 
ATOM 2060 C C   . CYS A 1 307 ? -34.07000 -8.41500  -43.86900 1.000 233.51413 ? 307 CYS F C   1 
ATOM 2061 O O   . CYS A 1 307 ? -33.61200 -9.34200  -44.53900 1.000 231.48616 ? 307 CYS F O   1 
ATOM 2062 C CB  . CYS A 1 307 ? -32.86200 -8.12600  -41.73400 1.000 228.34260 ? 307 CYS F CB  1 
ATOM 2063 S SG  . CYS A 1 307 ? -32.88200 -7.80300  -39.95600 1.000 231.39020 ? 307 CYS F SG  1 
ATOM 2064 N N   . GLN A 1 308 ? -34.36000 -7.19700  -44.37400 1.000 237.37532 ? 308 GLN F N   1 
ATOM 2065 C CA  . GLN A 1 308 ? -34.26400 -6.84900  -45.80200 1.000 235.02506 ? 308 GLN F CA  1 
ATOM 2066 C C   . GLN A 1 308 ? -32.93500 -6.18300  -46.10000 1.000 236.17021 ? 308 GLN F C   1 
ATOM 2067 O O   . GLN A 1 308 ? -32.80000 -4.95800  -46.14900 1.000 232.03297 ? 308 GLN F O   1 
ATOM 2068 C CB  . GLN A 1 308 ? -35.39700 -5.93300  -46.23500 1.000 225.71625 ? 308 GLN F CB  1 
ATOM 2069 C CG  . GLN A 1 308 ? -35.28300 -5.61300  -47.69100 1.000 225.39679 ? 308 GLN F CG  1 
ATOM 2070 C CD  . GLN A 1 308 ? -35.59200 -6.80300  -48.53500 1.000 240.50469 ? 308 GLN F CD  1 
ATOM 2071 O OE1 . GLN A 1 308 ? -35.99200 -7.85500  -48.02700 1.000 242.63809 ? 308 GLN F OE1 1 
ATOM 2072 N NE2 . GLN A 1 308 ? -35.33700 -6.68500  -49.82800 1.000 246.34774 ? 308 GLN F NE2 1 
ATOM 2073 N N   . ASN A 1 309 ? -31.97900 -7.02400  -46.44600 1.000 239.92266 ? 309 ASN F N   1 
ATOM 2074 C CA  . ASN A 1 309 ? -30.65300 -6.55300  -46.76500 1.000 242.49353 ? 309 ASN F CA  1 
ATOM 2075 C C   . ASN A 1 309 ? -30.28400 -6.93400  -48.19200 1.000 249.41594 ? 309 ASN F C   1 
ATOM 2076 O O   . ASN A 1 309 ? -30.50000 -8.07900  -48.61800 1.000 253.37557 ? 309 ASN F O   1 
ATOM 2077 C CB  . ASN A 1 309 ? -29.67300 -7.13000  -45.74900 1.000 244.30569 ? 309 ASN F CB  1 
ATOM 2078 C CG  . ASN A 1 309 ? -28.27200 -6.71200  -46.01600 1.000 256.94995 ? 309 ASN F CG  1 
ATOM 2079 O OD1 . ASN A 1 309 ? -28.04000 -5.65600  -46.60900 1.000 256.56876 ? 309 ASN F OD1 1 
ATOM 2080 N ND2 . ASN A 1 309 ? -27.31600 -7.53200  -45.59600 1.000 262.61961 ? 309 ASN F ND2 1 
ATOM 2081 N N   . ALA A 1 310 ? -29.86200 -5.93300  -48.96200 1.000 248.26384 ? 310 ALA F N   1 
ATOM 2082 C CA  . ALA A 1 310 ? -29.26600 -6.13300  -50.28800 1.000 250.12213 ? 310 ALA F CA  1 
ATOM 2083 C C   . ALA A 1 310 ? -30.13100 -6.96300  -51.24300 1.000 253.22636 ? 310 ALA F C   1 
ATOM 2084 O O   . ALA A 1 310 ? -29.60400 -7.79300  -51.99500 1.000 255.10315 ? 310 ALA F O   1 
ATOM 2085 C CB  . ALA A 1 310 ? -27.87300 -6.76400  -50.16700 1.000 248.94376 ? 310 ALA F CB  1 
ATOM 2086 N N   . GLY A 1 311 ? -31.46300 -6.86300  -51.12600 1.000 251.46760 ? 311 GLY F N   1 
ATOM 2087 C CA  . GLY A 1 311 ? -32.37900 -7.44200  -52.10000 1.000 251.65995 ? 311 GLY F CA  1 
ATOM 2088 C C   . GLY A 1 311 ? -32.89800 -8.80400  -51.73700 1.000 250.50469 ? 311 GLY F C   1 
ATOM 2089 O O   . GLY A 1 311 ? -33.61400 -9.43200  -52.53300 1.000 249.03128 ? 311 GLY F O   1 
ATOM 2090 N N   . SER A 1 312 ? -32.52600 -9.27800  -50.57100 1.000 252.44819 ? 312 SER F N   1 
ATOM 2091 C CA  . SER A 1 312 ? -32.90200 -10.57400 -50.06600 1.000 255.51655 ? 312 SER F CA  1 
ATOM 2092 C C   . SER A 1 312 ? -33.37300 -10.43900 -48.61800 1.000 253.69334 ? 312 SER F C   1 
ATOM 2093 O O   . SER A 1 312 ? -33.16300 -9.40600  -47.95400 1.000 251.99440 ? 312 SER F O   1 
ATOM 2094 C CB  . SER A 1 312 ? -31.73700 -11.55600 -50.34600 1.000 260.98926 ? 312 SER F CB  1 
ATOM 2095 O OG  . SER A 1 312 ? -30.58900 -11.28300 -49.56900 1.000 270.83517 ? 312 SER F OG  1 
ATOM 2096 N N   . THR A 1 313 ? -34.04400 -11.48100 -48.13900 1.000 247.46630 ? 313 THR F N   1 
ATOM 2097 C CA  . THR A 1 313 ? -34.53100 -11.52200 -46.77200 1.000 237.23123 ? 313 THR F CA  1 
ATOM 2098 C C   . THR A 1 313 ? -33.63000 -12.51200 -46.06900 1.000 241.67440 ? 313 THR F C   1 
ATOM 2099 O O   . THR A 1 313 ? -33.54700 -13.68200 -46.47000 1.000 244.97313 ? 313 THR F O   1 
ATOM 2100 C CB  . THR A 1 313 ? -35.97800 -11.98600 -46.69300 1.000 228.40237 ? 313 THR F CB  1 
ATOM 2101 O OG1 . THR A 1 313 ? -36.82200 -11.05100 -47.37000 1.000 232.52157 ? 313 THR F OG1 1 
ATOM 2102 C CG2 . THR A 1 313 ? -36.38800 -12.09400 -45.25500 1.000 230.64439 ? 313 THR F CG2 1 
ATOM 2103 N N   . VAL A 1 314 ? -33.10700 -12.08900 -44.92200 1.000 236.40028 ? 314 VAL F N   1 
ATOM 2104 C CA  . VAL A 1 314 ? -32.15900 -12.87500 -44.15700 1.000 236.89204 ? 314 VAL F CA  1 
ATOM 2105 C C   . VAL A 1 314 ? -32.88000 -13.34000 -42.91000 1.000 234.79017 ? 314 VAL F C   1 
ATOM 2106 O O   . VAL A 1 314 ? -33.48700 -12.52200 -42.20700 1.000 230.14680 ? 314 VAL F O   1 
ATOM 2107 C CB  . VAL A 1 314 ? -30.96800 -11.96000 -43.77300 1.000 227.38123 ? 314 VAL F CB  1 
ATOM 2108 C CG1 . VAL A 1 314 ? -29.95000 -12.63700 -42.89800 1.000 229.40692 ? 314 VAL F CG1 1 
ATOM 2109 C CG2 . VAL A 1 314 ? -30.34600 -11.24800 -44.96700 1.000 228.37793 ? 314 VAL F CG2 1 
ATOM 2110 N N   . TYR A 1 315 ? -32.83200 -14.66000 -42.65600 1.000 237.96377 ? 315 TYR F N   1 
ATOM 2111 C CA  . TYR A 1 315 ? -33.45800 -15.25800 -41.47700 1.000 235.94536 ? 315 TYR F CA  1 
ATOM 2112 C C   . TYR A 1 315 ? -32.37900 -15.56700 -40.43200 1.000 238.22958 ? 315 TYR F C   1 
ATOM 2113 O O   . TYR A 1 315 ? -31.36700 -16.21100 -40.74500 1.000 238.15031 ? 315 TYR F O   1 
ATOM 2114 C CB  . TYR A 1 315 ? -34.26300 -16.51400 -41.89400 1.000 236.69116 ? 315 TYR F CB  1 
ATOM 2115 C CG  . TYR A 1 315 ? -34.94200 -17.45000 -40.85100 1.000 234.50276 ? 315 TYR F CG  1 
ATOM 2116 C CD1 . TYR A 1 315 ? -35.61400 -16.94500 -39.74400 1.000 232.37073 ? 315 TYR F CD1 1 
ATOM 2117 C CD2 . TYR A 1 315 ? -34.96400 -18.83500 -41.02400 1.000 236.49468 ? 315 TYR F CD2 1 
ATOM 2118 C CE1 . TYR A 1 315 ? -36.25800 -17.79500 -38.83300 1.000 233.81815 ? 315 TYR F CE1 1 
ATOM 2119 C CE2 . TYR A 1 315 ? -35.59500 -19.68500 -40.10500 1.000 229.88650 ? 315 TYR F CE2 1 
ATOM 2120 C CZ  . TYR A 1 315 ? -36.23400 -19.15700 -39.01900 1.000 227.85950 ? 315 TYR F CZ  1 
ATOM 2121 O OH  . TYR A 1 315 ? -36.86400 -19.97900 -38.11600 1.000 229.24889 ? 315 TYR F OH  1 
ATOM 2122 N N   . TYR A 1 316 ? -32.56500 -15.04500 -39.21800 1.000 235.86357 ? 316 TYR F N   1 
ATOM 2123 C CA  . TYR A 1 316 ? -31.69300 -15.25200 -38.06300 1.000 234.38045 ? 316 TYR F CA  1 
ATOM 2124 C C   . TYR A 1 316 ? -32.54300 -16.13600 -37.15900 1.000 241.30159 ? 316 TYR F C   1 
ATOM 2125 O O   . TYR A 1 316 ? -33.34200 -15.61700 -36.35500 1.000 242.80077 ? 316 TYR F O   1 
ATOM 2126 C CB  . TYR A 1 316 ? -31.26200 -13.96200 -37.35900 1.000 227.32499 ? 316 TYR F CB  1 
ATOM 2127 C CG  . TYR A 1 316 ? -30.50700 -13.00900 -38.26400 1.000 233.01753 ? 316 TYR F CG  1 
ATOM 2128 C CD1 . TYR A 1 316 ? -31.18600 -12.11900 -39.07800 1.000 236.23437 ? 316 TYR F CD1 1 
ATOM 2129 C CD2 . TYR A 1 316 ? -29.11400 -13.04400 -38.35700 1.000 234.21154 ? 316 TYR F CD2 1 
ATOM 2130 C CE1 . TYR A 1 316 ? -30.51400 -11.25600 -39.92900 1.000 234.08772 ? 316 TYR F CE1 1 
ATOM 2131 C CE2 . TYR A 1 316 ? -28.42900 -12.17800 -39.21600 1.000 229.92539 ? 316 TYR F CE2 1 
ATOM 2132 C CZ  . TYR A 1 316 ? -29.14200 -11.28800 -39.99900 1.000 227.52121 ? 316 TYR F CZ  1 
ATOM 2133 O OH  . TYR A 1 316 ? -28.52100 -10.41700 -40.86000 1.000 216.75854 ? 316 TYR F OH  1 
ATOM 2134 N N   . PRO A 1 317 ? -32.41700 -17.47600 -37.24900 1.000 246.38126 ? 317 PRO F N   1 
ATOM 2135 C CA  . PRO A 1 317 ? -33.40100 -18.37000 -36.58900 1.000 251.93580 ? 317 PRO F CA  1 
ATOM 2136 C C   . PRO A 1 317 ? -33.20700 -18.48000 -35.08400 1.000 254.11378 ? 317 PRO F C   1 
ATOM 2137 O O   . PRO A 1 317 ? -34.14000 -18.89000 -34.36500 1.000 253.50131 ? 317 PRO F O   1 
ATOM 2138 C CB  . PRO A 1 317 ? -33.16300 -19.72700 -37.28900 1.000 243.71746 ? 317 PRO F CB  1 
ATOM 2139 C CG  . PRO A 1 317 ? -31.70900 -19.66700 -37.69400 1.000 240.42813 ? 317 PRO F CG  1 
ATOM 2140 C CD  . PRO A 1 317 ? -31.43900 -18.22400 -38.06300 1.000 237.76380 ? 317 PRO F CD  1 
ATOM 2141 N N   . ASN A 1 318 ? -32.04300 -18.08600 -34.59700 1.000 249.51560 ? 318 ASN F N   1 
ATOM 2142 C CA  . ASN A 1 318 ? -31.68600 -18.23600 -33.20800 1.000 240.08638 ? 318 ASN F CA  1 
ATOM 2143 C C   . ASN A 1 318 ? -31.79700 -16.85500 -32.62000 1.000 235.93841 ? 318 ASN F C   1 
ATOM 2144 O O   . ASN A 1 318 ? -31.71600 -15.84300 -33.32400 1.000 230.08979 ? 318 ASN F O   1 
ATOM 2145 C CB  . ASN A 1 318 ? -30.21100 -18.61700 -32.99900 1.000 239.37451 ? 318 ASN F CB  1 
ATOM 2146 C CG  . ASN A 1 318 ? -29.85400 -19.99900 -33.46300 1.000 244.76625 ? 318 ASN F CG  1 
ATOM 2147 O OD1 . ASN A 1 318 ? -30.64400 -20.92600 -33.33600 1.000 256.18536 ? 318 ASN F OD1 1 
ATOM 2148 N ND2 . ASN A 1 318 ? -28.63200 -20.15100 -33.99800 1.000 241.68602 ? 318 ASN F ND2 1 
ATOM 2149 N N   . GLU A 1 319 ? -32.08200 -16.80600 -31.34900 1.000 238.86835 ? 319 GLU F N   1 
ATOM 2150 C CA  . GLU A 1 319 ? -32.33200 -15.50100 -30.79400 1.000 245.56617 ? 319 GLU F CA  1 
ATOM 2151 C C   . GLU A 1 319 ? -31.01000 -14.74500 -30.87100 1.000 233.72713 ? 319 GLU F C   1 
ATOM 2152 O O   . GLU A 1 319 ? -30.92300 -13.70900 -31.53800 1.000 226.00403 ? 319 GLU F O   1 
ATOM 2153 C CB  . GLU A 1 319 ? -32.98300 -15.50900 -29.40300 1.000 275.03639 ? 319 GLU F CB  1 
ATOM 2154 C CG  . GLU A 1 319 ? -32.49900 -16.42200 -28.28900 1.000 299.86127 ? 319 GLU F CG  1 
ATOM 2155 C CD  . GLU A 1 319 ? -33.26300 -16.16800 -26.94600 1.000 322.92912 ? 319 GLU F CD  1 
ATOM 2156 O OE1 . GLU A 1 319 ? -33.98400 -15.13600 -26.82600 1.000 325.12888 ? 319 GLU F OE1 1 
ATOM 2157 O OE2 . GLU A 1 319 ? -33.11700 -16.99000 -26.00200 1.000 327.45685 ? 319 GLU F OE2 1 
ATOM 2158 N N   . LYS A 1 320 ? -29.92400 -15.39300 -30.39900 1.000 232.76313 ? 320 LYS F N   1 
ATOM 2159 C CA  . LYS A 1 320 ? -28.60600 -14.80000 -30.15900 1.000 228.55864 ? 320 LYS F CA  1 
ATOM 2160 C C   . LYS A 1 320 ? -27.95500 -14.19400 -31.37300 1.000 224.52123 ? 320 LYS F C   1 
ATOM 2161 O O   . LYS A 1 320 ? -26.89400 -13.56900 -31.23500 1.000 219.61151 ? 320 LYS F O   1 
ATOM 2162 C CB  . LYS A 1 320 ? -27.62500 -15.90200 -29.72900 1.000 233.52997 ? 320 LYS F CB  1 
ATOM 2163 C CG  . LYS A 1 320 ? -27.48700 -17.03500 -30.81300 1.000 237.61260 ? 320 LYS F CG  1 
ATOM 2164 C CD  . LYS A 1 320 ? -26.49200 -18.19600 -30.46800 1.000 241.02455 ? 320 LYS F CD  1 
ATOM 2165 C CE  . LYS A 1 320 ? -26.16800 -19.09700 -31.70300 1.000 236.71922 ? 320 LYS F CE  1 
ATOM 2166 N NZ  . LYS A 1 320 ? -25.21700 -20.24500 -31.48200 1.000 237.05368 ? 320 LYS F NZ  1 
ATOM 2167 N N   . ASP A 1 321 ? -28.52900 -14.36200 -32.54500 1.000 229.27737 ? 321 ASP F N   1 
ATOM 2168 C CA  . ASP A 1 321 ? -27.83400 -13.86900 -33.71400 1.000 236.64518 ? 321 ASP F CA  1 
ATOM 2169 C C   . ASP A 1 321 ? -28.21000 -12.40200 -33.85800 1.000 230.42695 ? 321 ASP F C   1 
ATOM 2170 O O   . ASP A 1 321 ? -27.42800 -11.59200 -34.36500 1.000 233.25678 ? 321 ASP F O   1 
ATOM 2171 C CB  . ASP A 1 321 ? -28.16000 -14.67300 -34.98900 1.000 242.14726 ? 321 ASP F CB  1 
ATOM 2172 C CG  . ASP A 1 321 ? -27.63900 -16.13700 -34.95800 1.000 244.54739 ? 321 ASP F CG  1 
ATOM 2173 O OD1 . ASP A 1 321 ? -26.60900 -16.42700 -34.28600 1.000 247.35065 ? 321 ASP F OD1 1 
ATOM 2174 O OD2 . ASP A 1 321 ? -28.22400 -16.98700 -35.67600 1.000 238.73859 ? 321 ASP F OD2 1 
ATOM 2175 N N   . CYS A 1 322 ? -29.38000 -12.05800 -33.32300 1.000 222.72836 ? 322 CYS F N   1 
ATOM 2176 C CA  . CYS A 1 322 ? -29.92400 -10.71400 -33.22400 1.000 219.48800 ? 322 CYS F CA  1 
ATOM 2177 C C   . CYS A 1 322 ? -30.26800 -10.40200 -31.77500 1.000 223.27713 ? 322 CYS F C   1 
ATOM 2178 O O   . CYS A 1 322 ? -30.41400 -11.30100 -30.94900 1.000 233.50273 ? 322 CYS F O   1 
ATOM 2179 C CB  . CYS A 1 322 ? -31.11800 -10.54200 -34.12300 1.000 218.47973 ? 322 CYS F CB  1 
ATOM 2180 S SG  . CYS A 1 322 ? -30.55400 -10.68800 -35.78100 1.000 219.25264 ? 322 CYS F SG  1 
ATOM 2181 N N   . GLU A 1 323 ? -30.37300 -9.10700  -31.47500 1.000 218.77389 ? 323 GLU F N   1 
ATOM 2182 C CA  . GLU A 1 323 ? -30.53000 -8.56200  -30.12900 1.000 229.82322 ? 323 GLU F CA  1 
ATOM 2183 C C   . GLU A 1 323 ? -31.21100 -7.21500  -30.24400 1.000 223.90599 ? 323 GLU F C   1 
ATOM 2184 O O   . GLU A 1 323 ? -30.80800 -6.40800  -31.07300 1.000 215.94065 ? 323 GLU F O   1 
ATOM 2185 C CB  . GLU A 1 323 ? -29.18000 -8.31500  -29.43200 1.000 233.83841 ? 323 GLU F CB  1 
ATOM 2186 C CG  . GLU A 1 323 ? -28.21200 -9.45900  -29.28200 1.000 241.43610 ? 323 GLU F CG  1 
ATOM 2187 C CD  . GLU A 1 323 ? -26.88600 -9.03400  -28.64800 1.000 245.60241 ? 323 GLU F CD  1 
ATOM 2188 O OE1 . GLU A 1 323 ? -26.73500 -7.84800  -28.26500 1.000 235.01831 ? 323 GLU F OE1 1 
ATOM 2189 O OE2 . GLU A 1 323 ? -26.02500 -9.92100  -28.46000 1.000 253.24235 ? 323 GLU F OE2 1 
ATOM 2190 N N   . THR A 1 324 ? -32.26200 -6.98200  -29.46000 1.000 232.29037 ? 324 THR F N   1 
ATOM 2191 C CA  . THR A 1 324 ? -32.98100 -5.72100  -29.59600 1.000 231.71605 ? 324 THR F CA  1 
ATOM 2192 C C   . THR A 1 324 ? -32.42600 -4.69500  -28.61700 1.000 234.70397 ? 324 THR F C   1 
ATOM 2193 O O   . THR A 1 324 ? -31.92300 -5.03900  -27.54200 1.000 238.36805 ? 324 THR F O   1 
ATOM 2194 C CB  . THR A 1 324 ? -34.47600 -5.88000  -29.33800 1.000 236.08898 ? 324 THR F CB  1 
ATOM 2195 O OG1 . THR A 1 324 ? -35.14500 -4.72500  -29.84900 1.000 243.91675 ? 324 THR F OG1 1 
ATOM 2196 C CG2 . THR A 1 324 ? -34.76200 -5.95900  -27.82400 1.000 237.81616 ? 324 THR F CG2 1 
ATOM 2197 N N   . ARG A 1 325 ? -32.51800 -3.41300  -29.00000 1.000 233.71486 ? 325 ARG F N   1 
ATOM 2198 C CA  . ARG A 1 325 ? -32.29300 -2.31700  -28.06800 1.000 233.06132 ? 325 ARG F CA  1 
ATOM 2199 C C   . ARG A 1 325 ? -33.33800 -1.21900  -28.33800 1.000 230.40046 ? 325 ARG F C   1 
ATOM 2200 O O   . ARG A 1 325 ? -33.14600 -0.39100  -29.24700 1.000 231.95570 ? 325 ARG F O   1 
ATOM 2201 C CB  . ARG A 1 325 ? -30.85500 -1.84300  -28.26300 1.000 239.30870 ? 325 ARG F CB  1 
ATOM 2202 C CG  . ARG A 1 325 ? -29.80700 -2.83200  -27.63400 1.000 253.11125 ? 325 ARG F CG  1 
ATOM 2203 C CD  . ARG A 1 325 ? -29.77500 -3.12300  -26.09600 1.000 261.03840 ? 325 ARG F CD  1 
ATOM 2204 N NE  . ARG A 1 325 ? -28.62800 -3.97800  -25.75000 1.000 263.01264 ? 325 ARG F NE  1 
ATOM 2205 C CZ  . ARG A 1 325 ? -28.40400 -4.56600  -24.57400 1.000 246.62624 ? 325 ARG F CZ  1 
ATOM 2206 N NH1 . ARG A 1 325 ? -29.23400 -4.43200  -23.55200 1.000 230.09016 ? 325 ARG F NH1 1 
ATOM 2207 N NH2 . ARG A 1 325 ? -27.33900 -5.35500  -24.43500 1.000 247.27931 ? 325 ARG F NH2 1 
ATOM 2208 N N   . GLY A 1 326 ? -34.51400 -1.31500  -27.70300 1.000 228.63388 ? 326 GLY F N   1 
ATOM 2209 C CA  . GLY A 1 326 ? -35.54500 -0.33700  -28.05500 1.000 229.94604 ? 326 GLY F CA  1 
ATOM 2210 C C   . GLY A 1 326 ? -36.08700 -0.63600  -29.43800 1.000 239.87057 ? 326 GLY F C   1 
ATOM 2211 O O   . GLY A 1 326 ? -36.55400 -1.74300  -29.69800 1.000 247.51112 ? 326 GLY F O   1 
ATOM 2212 N N   . ASP A 1 327 ? -36.24600 0.41400   -30.26200 1.000 241.70384 ? 327 ASP F N   1 
ATOM 2213 C CA  . ASP A 1 327 ? -36.67400 0.23600   -31.65500 1.000 238.21785 ? 327 ASP F CA  1 
ATOM 2214 C C   . ASP A 1 327 ? -35.56600 -0.26000  -32.61800 1.000 236.02510 ? 327 ASP F C   1 
ATOM 2215 O O   . ASP A 1 327 ? -35.89100 -0.62500  -33.75700 1.000 225.02277 ? 327 ASP F O   1 
ATOM 2216 C CB  . ASP A 1 327 ? -37.28200 1.53600   -32.21800 1.000 238.39887 ? 327 ASP F CB  1 
ATOM 2217 C CG  . ASP A 1 327 ? -36.39600 2.75500   -31.99300 1.000 251.70967 ? 327 ASP F CG  1 
ATOM 2218 O OD1 . ASP A 1 327 ? -35.44200 2.64800   -31.20500 1.000 258.17438 ? 327 ASP F OD1 1 
ATOM 2219 O OD2 . ASP A 1 327 ? -36.60200 3.80300   -32.65100 1.000 253.43537 ? 327 ASP F OD2 1 
ATOM 2220 N N   . HIS A 1 328 ? -34.27200 -0.24500  -32.23200 1.000 239.88654 ? 328 HIS F N   1 
ATOM 2221 C CA  . HIS A 1 328 ? -33.16100 -0.71800  -33.09300 1.000 236.16786 ? 328 HIS F CA  1 
ATOM 2222 C C   . HIS A 1 328 ? -32.83400 -2.20200  -32.85200 1.000 237.80550 ? 328 HIS F C   1 
ATOM 2223 O O   . HIS A 1 328 ? -32.93800 -2.67200  -31.71900 1.000 242.60768 ? 328 HIS F O   1 
ATOM 2224 C CB  . HIS A 1 328 ? -31.91400 0.16100   -32.91300 1.000 239.33279 ? 328 HIS F CB  1 
ATOM 2225 C CG  . HIS A 1 328 ? -32.02700 1.54800   -33.50900 1.000 249.43567 ? 328 HIS F CG  1 
ATOM 2226 N ND1 . HIS A 1 328 ? -32.82600 2.54500   -32.97900 1.000 261.42006 ? 328 HIS F ND1 1 
ATOM 2227 C CD2 . HIS A 1 328 ? -31.38600 2.11500   -34.56200 1.000 245.65119 ? 328 HIS F CD2 1 
ATOM 2228 C CE1 . HIS A 1 328 ? -32.69100 3.65400   -33.69000 1.000 258.44662 ? 328 HIS F CE1 1 
ATOM 2229 N NE2 . HIS A 1 328 ? -31.82000 3.42100   -34.65500 1.000 252.90849 ? 328 HIS F NE2 1 
ATOM 2230 N N   . VAL A 1 329 ? -32.46200 -2.96100  -33.89700 1.000 233.76166 ? 329 VAL F N   1 
ATOM 2231 C CA  . VAL A 1 329 ? -32.09800 -4.38000  -33.71800 1.000 230.42885 ? 329 VAL F CA  1 
ATOM 2232 C C   . VAL A 1 329 ? -30.68700 -4.68300  -34.24500 1.000 224.43952 ? 329 VAL F C   1 
ATOM 2233 O O   . VAL A 1 329 ? -30.42000 -4.55800  -35.44600 1.000 218.24337 ? 329 VAL F O   1 
ATOM 2234 C CB  . VAL A 1 329 ? -33.12100 -5.30800  -34.39300 1.000 222.63828 ? 329 VAL F CB  1 
ATOM 2235 C CG1 . VAL A 1 329 ? -33.37900 -4.86900  -35.83400 1.000 220.80045 ? 329 VAL F CG1 1 
ATOM 2236 C CG2 . VAL A 1 329 ? -32.66500 -6.76100  -34.31200 1.000 216.00874 ? 329 VAL F CG2 1 
ATOM 2237 N N   . PHE A 1 330 ? -29.83700 -5.21700  -33.35000 1.000 222.86121 ? 330 PHE F N   1 
ATOM 2238 C CA  . PHE A 1 330 ? -28.43900 -5.58700  -33.59400 1.000 218.74445 ? 330 PHE F CA  1 
ATOM 2239 C C   . PHE A 1 330 ? -28.32900 -7.04500  -34.03200 1.000 213.06533 ? 330 PHE F C   1 
ATOM 2240 O O   . PHE A 1 330 ? -28.62800 -7.95900  -33.26500 1.000 208.77937 ? 330 PHE F O   1 
ATOM 2241 C CB  . PHE A 1 330 ? -27.61100 -5.41500  -32.30600 1.000 217.06115 ? 330 PHE F CB  1 
ATOM 2242 C CG  . PHE A 1 330 ? -27.41000 -3.97300  -31.81300 1.000 215.46417 ? 330 PHE F CG  1 
ATOM 2243 C CD1 . PHE A 1 330 ? -28.44200 -3.21800  -31.27100 1.000 219.04946 ? 330 PHE F CD1 1 
ATOM 2244 C CD2 . PHE A 1 330 ? -26.12300 -3.45900  -31.72300 1.000 209.74142 ? 330 PHE F CD2 1 
ATOM 2245 C CE1 . PHE A 1 330 ? -28.21100 -1.92400  -30.79300 1.000 209.46054 ? 330 PHE F CE1 1 
ATOM 2246 C CE2 . PHE A 1 330 ? -25.88900 -2.18900  -31.23400 1.000 205.34185 ? 330 PHE F CE2 1 
ATOM 2247 C CZ  . PHE A 1 330 ? -26.93400 -1.42200  -30.76900 1.000 203.19837 ? 330 PHE F CZ  1 
ATOM 2248 N N   . CYS A 1 331 ? -27.90200 -7.26400  -35.26400 1.000 212.64997 ? 331 CYS F N   1 
ATOM 2249 C CA  . CYS A 1 331 ? -27.74000 -8.60100  -35.80500 1.000 213.77806 ? 331 CYS F CA  1 
ATOM 2250 C C   . CYS A 1 331 ? -26.34300 -8.83100  -36.32300 1.000 209.21404 ? 331 CYS F C   1 
ATOM 2251 O O   . CYS A 1 331 ? -25.71300 -7.90600  -36.82400 1.000 202.56491 ? 331 CYS F O   1 
ATOM 2252 C CB  . CYS A 1 331 ? -28.68600 -8.82600  -36.93700 1.000 215.57380 ? 331 CYS F CB  1 
ATOM 2253 S SG  . CYS A 1 331 ? -30.27700 -8.75100  -36.32900 1.000 214.60228 ? 331 CYS F SG  1 
ATOM 2254 N N   . ASP A 1 332 ? -25.81800 -10.03200 -36.15800 1.000 210.56838 ? 332 ASP F N   1 
ATOM 2255 C CA  . ASP A 1 332 ? -24.59600 -10.32300 -36.86900 1.000 202.18292 ? 332 ASP F CA  1 
ATOM 2256 C C   . ASP A 1 332 ? -25.12500 -10.93300 -38.16900 1.000 212.52769 ? 332 ASP F C   1 
ATOM 2257 O O   . ASP A 1 332 ? -25.68800 -12.02800 -38.15100 1.000 218.46078 ? 332 ASP F O   1 
ATOM 2258 C CB  . ASP A 1 332 ? -23.76100 -11.26900 -36.01600 1.000 197.53464 ? 332 ASP F CB  1 
ATOM 2259 C CG  . ASP A 1 332 ? -22.35400 -11.36100 -36.45600 1.000 199.58360 ? 332 ASP F CG  1 
ATOM 2260 O OD1 . ASP A 1 332 ? -22.06900 -11.49600 -37.65500 1.000 209.02227 ? 332 ASP F OD1 1 
ATOM 2261 O OD2 . ASP A 1 332 ? -21.50900 -11.24200 -35.56400 1.000 199.75444 ? 332 ASP F OD2 1 
ATOM 2262 N N   . THR A 1 333 ? -24.89900 -10.26400 -39.29800 1.000 215.90722 ? 333 THR F N   1 
ATOM 2263 C CA  . THR A 1 333 ? -25.47000 -10.73500 -40.57100 1.000 224.53871 ? 333 THR F CA  1 
ATOM 2264 C C   . THR A 1 333 ? -24.90800 -12.04500 -41.10200 1.000 224.97424 ? 333 THR F C   1 
ATOM 2265 O O   . THR A 1 333 ? -25.64400 -12.80800 -41.74000 1.000 224.63579 ? 333 THR F O   1 
ATOM 2266 C CB  . THR A 1 333 ? -25.38300 -9.66600  -41.64500 1.000 238.79552 ? 333 THR F CB  1 
ATOM 2267 O OG1 . THR A 1 333 ? -24.01900 -9.27300  -41.83500 1.000 252.01819 ? 333 THR F OG1 1 
ATOM 2268 C CG2 . THR A 1 333 ? -26.25300 -8.51600  -41.30300 1.000 233.70467 ? 333 THR F CG2 1 
ATOM 2269 N N   . ALA A 1 334 ? -23.63900 -12.35100 -40.83200 1.000 224.10721 ? 334 ALA F N   1 
ATOM 2270 C CA  . ALA A 1 334 ? -23.08600 -13.60500 -41.33300 1.000 224.99920 ? 334 ALA F CA  1 
ATOM 2271 C C   . ALA A 1 334 ? -23.76500 -14.79200 -40.70900 1.000 234.61892 ? 334 ALA F C   1 
ATOM 2272 O O   . ALA A 1 334 ? -23.54900 -15.91900 -41.17200 1.000 245.43274 ? 334 ALA F O   1 
ATOM 2273 C CB  . ALA A 1 334 ? -21.57600 -13.69600 -41.13300 1.000 217.52366 ? 334 ALA F CB  1 
ATOM 2274 N N   . ALA A 1 335 ? -24.66700 -14.53000 -39.76400 1.000 234.70259 ? 335 ALA F N   1 
ATOM 2275 C CA  . ALA A 1 335 ? -25.39100 -15.52700 -38.99800 1.000 238.37473 ? 335 ALA F CA  1 
ATOM 2276 C C   . ALA A 1 335 ? -26.72500 -15.83300 -39.64500 1.000 239.19688 ? 335 ALA F C   1 
ATOM 2277 O O   . ALA A 1 335 ? -27.46800 -16.68100 -39.13000 1.000 232.83442 ? 335 ALA F O   1 
ATOM 2278 C CB  . ALA A 1 335 ? -25.60900 -15.06800 -37.55400 1.000 236.51577 ? 335 ALA F CB  1 
ATOM 2279 N N   . GLY A 1 336 ? -27.08600 -15.09600 -40.70700 1.000 242.66962 ? 336 GLY F N   1 
ATOM 2280 C CA  . GLY A 1 336 ? -28.39600 -15.21800 -41.29700 1.000 244.13566 ? 336 GLY F CA  1 
ATOM 2281 C C   . GLY A 1 336 ? -28.30600 -16.07500 -42.57000 1.000 245.48981 ? 336 GLY F C   1 
ATOM 2282 O O   . GLY A 1 336 ? -27.22500 -16.35600 -43.09600 1.000 246.42144 ? 336 GLY F O   1 
ATOM 2283 N N   . ILE A 1 337 ? -29.48200 -16.44500 -43.08200 1.000 242.09945 ? 337 ILE F N   1 
ATOM 2284 C CA  . ILE A 1 337 ? -29.65500 -17.19800 -44.33300 1.000 246.34870 ? 337 ILE F CA  1 
ATOM 2285 C C   . ILE A 1 337 ? -30.55400 -16.52300 -45.36900 1.000 255.26158 ? 337 ILE F C   1 
ATOM 2286 O O   . ILE A 1 337 ? -31.66600 -16.08600 -45.02800 1.000 250.10659 ? 337 ILE F O   1 
ATOM 2287 C CB  . ILE A 1 337 ? -30.17700 -18.58700 -43.98300 1.000 246.67997 ? 337 ILE F CB  1 
ATOM 2288 C CG1 . ILE A 1 337 ? -31.16500 -18.36600 -42.82700 1.000 246.82850 ? 337 ILE F CG1 1 
ATOM 2289 C CG2 . ILE A 1 337 ? -28.99200 -19.49500 -43.68800 1.000 257.35393 ? 337 ILE F CG2 1 
ATOM 2290 C CD1 . ILE A 1 337 ? -31.83100 -19.56100 -42.26400 1.000 255.51422 ? 337 ILE F CD1 1 
ATOM 2291 N N   . ASN A 1 338 ? -30.05900 -16.39900 -46.62500 1.000 270.92301 ? 338 ASN F N   1 
ATOM 2292 C CA  . ASN A 1 338 ? -30.91400 -15.86700 -47.69400 1.000 270.98899 ? 338 ASN F CA  1 
ATOM 2293 C C   . ASN A 1 338 ? -32.04100 -16.83700 -47.99000 1.000 259.23626 ? 338 ASN F C   1 
ATOM 2294 O O   . ASN A 1 338 ? -31.85200 -17.91500 -48.56500 1.000 257.49412 ? 338 ASN F O   1 
ATOM 2295 C CB  . ASN A 1 338 ? -30.14900 -15.61700 -49.00100 1.000 278.61228 ? 338 ASN F CB  1 
ATOM 2296 C CG  . ASN A 1 338 ? -29.53300 -14.20800 -49.10700 1.000 285.60653 ? 338 ASN F CG  1 
ATOM 2297 O OD1 . ASN A 1 338 ? -29.78700 -13.34300 -48.27100 1.000 293.65772 ? 338 ASN F OD1 1 
ATOM 2298 N ND2 . ASN A 1 338 ? -28.76500 -13.96700 -50.17800 1.000 272.31005 ? 338 ASN F ND2 1 
ATOM 2299 N N   . VAL A 1 339 ? -33.22500 -16.37900 -47.70700 1.000 251.76881 ? 339 VAL F N   1 
ATOM 2300 C CA  . VAL A 1 339 ? -34.42200 -17.12600 -47.93800 1.000 256.69928 ? 339 VAL F CA  1 
ATOM 2301 C C   . VAL A 1 339 ? -35.15300 -16.34600 -48.99900 1.000 269.38722 ? 339 VAL F C   1 
ATOM 2302 O O   . VAL A 1 339 ? -34.85900 -15.16800 -49.22800 1.000 260.88246 ? 339 VAL F O   1 
ATOM 2303 C CB  . VAL A 1 339 ? -35.22000 -17.33900 -46.65700 1.000 255.50008 ? 339 VAL F CB  1 
ATOM 2304 C CG1 . VAL A 1 339 ? -34.44300 -18.28400 -45.80400 1.000 248.80376 ? 339 VAL F CG1 1 
ATOM 2305 C CG2 . VAL A 1 339 ? -35.34000 -16.02800 -45.92900 1.000 252.46948 ? 339 VAL F CG2 1 
ATOM 2306 N N   . ALA A 1 340 ? -36.03300 -17.02600 -49.72200 1.000 290.55727 ? 340 ALA F N   1 
ATOM 2307 C CA  . ALA A 1 340 ? -36.84200 -16.32600 -50.71300 1.000 309.35694 ? 340 ALA F CA  1 
ATOM 2308 C C   . ALA A 1 340 ? -37.79700 -15.33200 -50.04100 1.000 314.98026 ? 340 ALA F C   1 
ATOM 2309 O O   . ALA A 1 340 ? -38.21900 -15.51800 -48.89700 1.000 315.89598 ? 340 ALA F O   1 
ATOM 2310 C CB  . ALA A 1 340 ? -37.64300 -17.33500 -51.54500 1.000 314.88461 ? 340 ALA F CB  1 
ATOM 2311 N N   . GLU A 1 341 ? -38.09500 -14.24000 -50.76200 1.000 318.07906 ? 341 GLU F N   1 
ATOM 2312 C CA  . GLU A 1 341 ? -39.04400 -13.18200 -50.39200 1.000 315.77301 ? 341 GLU F CA  1 
ATOM 2313 C C   . GLU A 1 341 ? -40.48300 -13.67500 -50.13400 1.000 325.68942 ? 341 GLU F C   1 
ATOM 2314 O O   . GLU A 1 341 ? -41.36200 -12.86700 -49.80500 1.000 323.27444 ? 341 GLU F O   1 
ATOM 2315 C CB  . GLU A 1 341 ? -39.06600 -12.09100 -51.48500 1.000 314.24526 ? 341 GLU F CB  1 
ATOM 2316 C CG  . GLU A 1 341 ? -37.72500 -11.79200 -52.24800 1.000 303.99044 ? 341 GLU F CG  1 
ATOM 2317 C CD  . GLU A 1 341 ? -36.59700 -11.13200 -51.44600 1.000 276.15356 ? 341 GLU F CD  1 
ATOM 2318 O OE1 . GLU A 1 341 ? -36.87400 -10.41000 -50.46300 1.000 269.38917 ? 341 GLU F OE1 1 
ATOM 2319 O OE2 . GLU A 1 341 ? -35.42100 -11.29800 -51.85800 1.000 265.10554 ? 341 GLU F OE2 1 
ATOM 2320 N N   . GLN A 1 342 ? -40.72800 -14.99000 -50.30500 1.000 328.98874 ? 342 GLN F N   1 
ATOM 2321 C CA  . GLN A 1 342 ? -42.01300 -15.70800 -50.19500 1.000 327.11295 ? 342 GLN F CA  1 
ATOM 2322 C C   . GLN A 1 342 ? -42.69300 -15.68800 -48.81600 1.000 328.00556 ? 342 GLN F C   1 
ATOM 2323 O O   . GLN A 1 342 ? -43.86900 -16.08500 -48.74000 1.000 331.88656 ? 342 GLN F O   1 
ATOM 2324 C CB  . GLN A 1 342 ? -41.84900 -17.19600 -50.57200 1.000 330.19395 ? 342 GLN F CB  1 
ATOM 2325 C CG  . GLN A 1 342 ? -41.46900 -17.56900 -52.01800 1.000 327.83903 ? 342 GLN F CG  1 
ATOM 2326 C CD  . GLN A 1 342 ? -42.63000 -17.53400 -52.99900 1.000 330.41914 ? 342 GLN F CD  1 
ATOM 2327 O OE1 . GLN A 1 342 ? -43.64500 -18.20800 -52.81100 1.000 332.51452 ? 342 GLN F OE1 1 
ATOM 2328 N NE2 . GLN A 1 342 ? -42.44700 -16.80800 -54.09600 1.000 329.42428 ? 342 GLN F NE2 1 
ATOM 2329 N N   . SER A 1 343 ? -42.01900 -15.26300 -47.73000 1.000 324.52884 ? 343 SER F N   1 
ATOM 2330 C CA  . SER A 1 343 ? -42.66800 -15.32500 -46.41600 1.000 323.85800 ? 343 SER F CA  1 
ATOM 2331 C C   . SER A 1 343 ? -43.91000 -14.46200 -46.24900 1.000 330.47807 ? 343 SER F C   1 
ATOM 2332 O O   . SER A 1 343 ? -44.72700 -14.78900 -45.37100 1.000 336.24363 ? 343 SER F O   1 
ATOM 2333 C CB  . SER A 1 343 ? -41.71600 -14.87200 -45.29900 1.000 305.72317 ? 343 SER F CB  1 
ATOM 2334 O OG  . SER A 1 343 ? -41.38300 -13.49600 -45.44300 1.000 291.76320 ? 343 SER F OG  1 
ATOM 2335 N N   . LYS A 1 344 ? -44.17200 -13.45400 -47.09600 1.000 330.78241 ? 344 LYS F N   1 
ATOM 2336 C CA  . LYS A 1 344 ? -45.41800 -12.80600 -46.73200 1.000 331.24681 ? 344 LYS F CA  1 
ATOM 2337 C C   . LYS A 1 344 ? -46.60500 -13.66200 -47.17000 1.000 342.17966 ? 344 LYS F C   1 
ATOM 2338 O O   . LYS A 1 344 ? -47.68300 -13.54700 -46.56100 1.000 346.68069 ? 344 LYS F O   1 
ATOM 2339 C CB  . LYS A 1 344 ? -45.54000 -11.39600 -47.35500 1.000 324.62954 ? 344 LYS F CB  1 
ATOM 2340 C CG  . LYS A 1 344 ? -44.26100 -10.56800 -47.59800 1.000 308.44691 ? 344 LYS F CG  1 
ATOM 2341 C CD  . LYS A 1 344 ? -43.56400 -10.14400 -46.32200 1.000 292.69187 ? 344 LYS F CD  1 
ATOM 2342 C CE  . LYS A 1 344 ? -42.31200 -9.35400  -46.64800 1.000 277.51544 ? 344 LYS F CE  1 
ATOM 2343 N NZ  . LYS A 1 344 ? -41.40700 -10.06800 -47.57800 1.000 279.05279 ? 344 LYS F NZ  1 
ATOM 2344 N N   . GLU A 1 345 ? -46.41800 -14.57100 -48.15900 1.000 345.04333 ? 345 GLU F N   1 
ATOM 2345 C CA  . GLU A 1 345 ? -47.52400 -15.46100 -48.52200 1.000 340.55586 ? 345 GLU F CA  1 
ATOM 2346 C C   . GLU A 1 345 ? -47.82000 -16.50200 -47.44000 1.000 345.98822 ? 345 GLU F C   1 
ATOM 2347 O O   . GLU A 1 345 ? -48.79900 -17.24800 -47.58500 1.000 344.43280 ? 345 GLU F O   1 
ATOM 2348 C CB  . GLU A 1 345 ? -47.30200 -16.11200 -49.89200 1.000 326.03275 ? 345 GLU F CB  1 
ATOM 2349 C CG  . GLU A 1 345 ? -47.42700 -15.08100 -51.00400 1.000 314.37266 ? 345 GLU F CG  1 
ATOM 2350 C CD  . GLU A 1 345 ? -48.85300 -14.55400 -51.16000 1.000 306.24962 ? 345 GLU F CD  1 
ATOM 2351 O OE1 . GLU A 1 345 ? -49.81600 -15.30500 -50.89700 1.000 306.27160 ? 345 GLU F OE1 1 
ATOM 2352 O OE2 . GLU A 1 345 ? -49.00900 -13.36200 -51.50300 1.000 298.71763 ? 345 GLU F OE2 1 
ATOM 2353 N N   . CYS A 1 346 ? -46.90900 -16.68900 -46.46600 1.000 348.29965 ? 346 CYS F N   1 
ATOM 2354 C CA  . CYS A 1 346 ? -47.18500 -17.49200 -45.27000 1.000 336.32980 ? 346 CYS F CA  1 
ATOM 2355 C C   . CYS A 1 346 ? -48.24900 -16.85300 -44.33500 1.000 335.88375 ? 346 CYS F C   1 
ATOM 2356 O O   . CYS A 1 346 ? -48.83200 -17.58300 -43.52000 1.000 322.84450 ? 346 CYS F O   1 
ATOM 2357 C CB  . CYS A 1 346 ? -45.86400 -17.82400 -44.54900 1.000 329.74576 ? 346 CYS F CB  1 
ATOM 2358 S SG  . CYS A 1 346 ? -45.03000 -19.49200 -44.87800 1.000 306.53052 ? 346 CYS F SG  1 
ATOM 2359 N N   . ASN A 1 347 ? -48.50500 -15.51300 -44.42200 1.000 343.15380 ? 347 ASN F N   1 
ATOM 2360 C CA  . ASN A 1 347 ? -49.55800 -14.78000 -43.67700 1.000 329.31307 ? 347 ASN F CA  1 
ATOM 2361 C C   . ASN A 1 347 ? -50.91000 -14.65100 -44.38600 1.000 339.78866 ? 347 ASN F C   1 
ATOM 2362 O O   . ASN A 1 347 ? -51.95200 -14.67300 -43.72100 1.000 331.78836 ? 347 ASN F O   1 
ATOM 2363 C CB  . ASN A 1 347 ? -49.08800 -13.36000 -43.34800 1.000 310.31154 ? 347 ASN F CB  1 
ATOM 2364 C CG  . ASN A 1 347 ? -47.71200 -13.33000 -42.79700 1.000 311.29900 ? 347 ASN F CG  1 
ATOM 2365 O OD1 . ASN A 1 347 ? -47.27700 -14.28400 -42.16100 1.000 315.24064 ? 347 ASN F OD1 1 
ATOM 2366 N ND2 . ASN A 1 347 ? -46.98400 -12.26500 -43.08400 1.000 313.35809 ? 347 ASN F ND2 1 
ATOM 2367 N N   . ILE A 1 348 ? -50.90900 -14.39500 -45.69900 1.000 351.03393 ? 348 ILE F N   1 
ATOM 2368 C CA  . ILE A 1 348 ? -52.10900 -14.10300 -46.49400 1.000 351.30090 ? 348 ILE F CA  1 
ATOM 2369 C C   . ILE A 1 348 ? -52.90300 -15.38800 -46.71300 1.000 353.98637 ? 348 ILE F C   1 
ATOM 2370 O O   . ILE A 1 348 ? -54.06500 -15.49000 -46.30500 1.000 355.32926 ? 348 ILE F O   1 
ATOM 2371 C CB  . ILE A 1 348 ? -51.81500 -13.42700 -47.85300 1.000 334.83708 ? 348 ILE F CB  1 
ATOM 2372 C CG1 . ILE A 1 348 ? -51.07000 -12.09800 -47.67400 1.000 323.64516 ? 348 ILE F CG1 1 
ATOM 2373 C CG2 . ILE A 1 348 ? -53.10400 -13.30700 -48.70800 1.000 323.84500 ? 348 ILE F CG2 1 
ATOM 2374 C CD1 . ILE A 1 348 ? -50.59900 -11.49900 -48.97600 1.000 314.78623 ? 348 ILE F CD1 1 
ATOM 2375 N N   . ASN A 1 349 ? -52.30600 -16.34300 -47.43600 1.000 352.45200 ? 349 ASN F N   1 
ATOM 2376 C CA  . ASN A 1 349 ? -52.94200 -17.61000 -47.80200 1.000 345.19477 ? 349 ASN F CA  1 
ATOM 2377 C C   . ASN A 1 349 ? -52.04300 -18.84400 -47.47900 1.000 341.31333 ? 349 ASN F C   1 
ATOM 2378 O O   . ASN A 1 349 ? -51.61100 -19.56300 -48.38100 1.000 341.97704 ? 349 ASN F O   1 
ATOM 2379 C CB  . ASN A 1 349 ? -53.26800 -17.40700 -49.27800 1.000 331.11478 ? 349 ASN F CB  1 
ATOM 2380 C CG  . ASN A 1 349 ? -54.72700 -17.57300 -49.58200 1.000 325.96221 ? 349 ASN F CG  1 
ATOM 2381 O OD1 . ASN A 1 349 ? -55.44700 -18.30300 -48.91200 1.000 335.57511 ? 349 ASN F OD1 1 
ATOM 2382 N ND2 . ASN A 1 349 ? -55.18900 -16.83700 -50.58600 1.000 320.22235 ? 349 ASN F ND2 1 
ATOM 2383 N N   . ILE A 1 350 ? -51.75200 -19.08100 -46.18200 1.000 332.39037 ? 350 ILE F N   1 
ATOM 2384 C CA  . ILE A 1 350 ? -50.74500 -20.06600 -45.73600 1.000 321.11870 ? 350 ILE F CA  1 
ATOM 2385 C C   . ILE A 1 350 ? -50.98100 -21.52400 -46.16800 1.000 327.18185 ? 350 ILE F C   1 
ATOM 2386 O O   . ILE A 1 350 ? -50.01100 -22.26400 -46.37200 1.000 324.12495 ? 350 ILE F O   1 
ATOM 2387 C CB  . ILE A 1 350 ? -50.59600 -19.99200 -44.20200 1.000 312.07134 ? 350 ILE F CB  1 
ATOM 2388 C CG1 . ILE A 1 350 ? -49.39600 -20.83900 -43.77600 1.000 308.91834 ? 350 ILE F CG1 1 
ATOM 2389 C CG2 . ILE A 1 350 ? -51.89700 -20.36900 -43.47700 1.000 308.12483 ? 350 ILE F CG2 1 
ATOM 2390 C CD1 . ILE A 1 350 ? -49.05400 -20.76300 -42.34700 1.000 307.37234 ? 350 ILE F CD1 1 
ATOM 2391 N N   . SER A 1 351 ? -52.23400 -21.96500 -46.33900 1.000 336.59428 ? 351 SER F N   1 
ATOM 2392 C CA  . SER A 1 351 ? -52.50800 -23.36400 -46.72200 1.000 336.03157 ? 351 SER F CA  1 
ATOM 2393 C C   . SER A 1 351 ? -52.27100 -23.57700 -48.21400 1.000 341.11749 ? 351 SER F C   1 
ATOM 2394 O O   . SER A 1 351 ? -51.79700 -24.63800 -48.64100 1.000 336.12939 ? 351 SER F O   1 
ATOM 2395 C CB  . SER A 1 351 ? -53.91300 -23.81400 -46.29700 1.000 327.93706 ? 351 SER F CB  1 
ATOM 2396 O OG  . SER A 1 351 ? -54.92400 -22.87600 -46.59900 1.000 331.27275 ? 351 SER F OG  1 
ATOM 2397 N N   . THR A 1 352 ? -52.66000 -22.58300 -48.99800 1.000 349.69392 ? 352 THR F N   1 
ATOM 2398 C CA  . THR A 1 352 ? -52.70400 -22.53700 -50.45000 1.000 354.21247 ? 352 THR F CA  1 
ATOM 2399 C C   . THR A 1 352 ? -51.45900 -21.86700 -51.01900 1.000 358.82643 ? 352 THR F C   1 
ATOM 2400 O O   . THR A 1 352 ? -51.31000 -21.82500 -52.24300 1.000 368.46334 ? 352 THR F O   1 
ATOM 2401 C CB  . THR A 1 352 ? -53.95500 -21.82000 -50.97800 1.000 351.19510 ? 352 THR F CB  1 
ATOM 2402 O OG1 . THR A 1 352 ? -54.12900 -22.14300 -52.36400 1.000 349.29173 ? 352 THR F OG1 1 
ATOM 2403 C CG2 . THR A 1 352 ? -53.77700 -20.34600 -50.90900 1.000 340.01698 ? 352 THR F CG2 1 
ATOM 2404 N N   . THR A 1 353 ? -50.58000 -21.32900 -50.16300 1.000 354.42014 ? 353 THR F N   1 
ATOM 2405 C CA  . THR A 1 353 ? -49.41800 -20.55900 -50.60600 1.000 357.19515 ? 353 THR F CA  1 
ATOM 2406 C C   . THR A 1 353 ? -48.50100 -21.46900 -51.42700 1.000 366.42989 ? 353 THR F C   1 
ATOM 2407 O O   . THR A 1 353 ? -48.46600 -22.68800 -51.23000 1.000 369.01999 ? 353 THR F O   1 
ATOM 2408 C CB  . THR A 1 353 ? -48.68200 -19.94900 -49.40100 1.000 340.78049 ? 353 THR F CB  1 
ATOM 2409 O OG1 . THR A 1 353 ? -47.53500 -19.21600 -49.84500 1.000 337.54336 ? 353 THR F OG1 1 
ATOM 2410 C CG2 . THR A 1 353 ? -48.24200 -21.00700 -48.41300 1.000 330.79509 ? 353 THR F CG2 1 
ATOM 2411 N N   . ASN A 1 354 ? -47.72700 -20.85200 -52.34500 1.000 365.49722 ? 354 ASN F N   1 
ATOM 2412 C CA  . ASN A 1 354 ? -46.77800 -21.59100 -53.18800 1.000 364.29362 ? 354 ASN F CA  1 
ATOM 2413 C C   . ASN A 1 354 ? -45.48200 -22.01300 -52.49100 1.000 372.03770 ? 354 ASN F C   1 
ATOM 2414 O O   . ASN A 1 354 ? -45.04600 -23.15800 -52.68200 1.000 375.01952 ? 354 ASN F O   1 
ATOM 2415 C CB  . ASN A 1 354 ? -46.44700 -20.73800 -54.42500 1.000 353.87151 ? 354 ASN F CB  1 
ATOM 2416 C CG  . ASN A 1 354 ? -47.63100 -20.56800 -55.36200 1.000 355.62979 ? 354 ASN F CG  1 
ATOM 2417 O OD1 . ASN A 1 354 ? -48.52800 -21.40400 -55.40000 1.000 361.80504 ? 354 ASN F OD1 1 
ATOM 2418 N ND2 . ASN A 1 354 ? -47.64400 -19.46800 -56.10700 1.000 351.41451 ? 354 ASN F ND2 1 
ATOM 2419 N N   . TYR A 1 355 ? -44.78300 -21.11300 -51.74600 1.000 370.79403 ? 355 TYR F N   1 
ATOM 2420 C CA  . TYR A 1 355 ? -43.62800 -21.77700 -51.11900 1.000 372.24363 ? 355 TYR F CA  1 
ATOM 2421 C C   . TYR A 1 355 ? -44.17500 -22.61400 -49.95000 1.000 373.63331 ? 355 TYR F C   1 
ATOM 2422 O O   . TYR A 1 355 ? -45.05300 -22.14000 -49.21800 1.000 371.90860 ? 355 TYR F O   1 
ATOM 2423 C CB  . TYR A 1 355 ? -42.57800 -20.72200 -50.64300 1.000 367.66769 ? 355 TYR F CB  1 
ATOM 2424 C CG  . TYR A 1 355 ? -41.18000 -21.18900 -50.13200 1.000 368.13375 ? 355 TYR F CG  1 
ATOM 2425 C CD1 . TYR A 1 355 ? -40.10900 -21.40500 -51.01300 1.000 370.23295 ? 355 TYR F CD1 1 
ATOM 2426 C CD2 . TYR A 1 355 ? -40.92000 -21.35000 -48.76500 1.000 368.05177 ? 355 TYR F CD2 1 
ATOM 2427 C CE1 . TYR A 1 355 ? -38.82700 -21.80800 -50.53800 1.000 374.44038 ? 355 TYR F CE1 1 
ATOM 2428 C CE2 . TYR A 1 355 ? -39.64700 -21.75400 -48.28700 1.000 362.25262 ? 355 TYR F CE2 1 
ATOM 2429 C CZ  . TYR A 1 355 ? -38.60900 -21.98100 -49.17100 1.000 367.83893 ? 355 TYR F CZ  1 
ATOM 2430 O OH  . TYR A 1 355 ? -37.37100 -22.37400 -48.67200 1.000 355.38633 ? 355 TYR F OH  1 
ATOM 2431 N N   . PRO A 1 356 ? -43.69300 -23.88300 -49.73400 1.000 368.85167 ? 356 PRO F N   1 
ATOM 2432 C CA  . PRO A 1 356 ? -44.21000 -24.66300 -48.59100 1.000 359.68058 ? 356 PRO F CA  1 
ATOM 2433 C C   . PRO A 1 356 ? -43.71000 -24.22500 -47.20900 1.000 357.91437 ? 356 PRO F C   1 
ATOM 2434 O O   . PRO A 1 356 ? -42.54400 -24.45100 -46.84700 1.000 347.99574 ? 356 PRO F O   1 
ATOM 2435 C CB  . PRO A 1 356 ? -43.81900 -26.10300 -48.96400 1.000 337.61166 ? 356 PRO F CB  1 
ATOM 2436 C CG  . PRO A 1 356 ? -42.65700 -25.96500 -49.76900 1.000 331.67071 ? 356 PRO F CG  1 
ATOM 2437 C CD  . PRO A 1 356 ? -42.81800 -24.71500 -50.58400 1.000 357.06437 ? 356 PRO F CD  1 
ATOM 2438 N N   . CYS A 1 357 ? -44.64900 -23.67000 -46.40800 1.000 359.86432 ? 357 CYS F N   1 
ATOM 2439 C CA  . CYS A 1 357 ? -44.35900 -23.13700 -45.07500 1.000 346.43586 ? 357 CYS F CA  1 
ATOM 2440 C C   . CYS A 1 357 ? -43.96800 -24.31900 -44.21100 1.000 342.58335 ? 357 CYS F C   1 
ATOM 2441 O O   . CYS A 1 357 ? -44.71400 -25.28100 -44.10800 1.000 345.80410 ? 357 CYS F O   1 
ATOM 2442 C CB  . CYS A 1 357 ? -45.60900 -22.47500 -44.44400 1.000 326.32028 ? 357 CYS F CB  1 
ATOM 2443 S SG  . CYS A 1 357 ? -46.40000 -20.95300 -45.13300 1.000 293.80468 ? 357 CYS F SG  1 
ATOM 2444 N N   . LYS A 1 358 ? -42.84500 -24.24800 -43.53400 1.000 338.67457 ? 358 LYS F N   1 
ATOM 2445 C CA  . LYS A 1 358 ? -42.37900 -25.43900 -42.84600 1.000 339.68068 ? 358 LYS F CA  1 
ATOM 2446 C C   . LYS A 1 358 ? -43.15000 -25.53300 -41.53500 1.000 335.32753 ? 358 LYS F C   1 
ATOM 2447 O O   . LYS A 1 358 ? -43.39900 -24.51100 -40.89000 1.000 323.09638 ? 358 LYS F O   1 
ATOM 2448 C CB  . LYS A 1 358 ? -40.86600 -25.42400 -42.57700 1.000 335.35489 ? 358 LYS F CB  1 
ATOM 2449 C CG  . LYS A 1 358 ? -39.79100 -25.71300 -43.70500 1.000 330.09212 ? 358 LYS F CG  1 
ATOM 2450 C CD  . LYS A 1 358 ? -39.57800 -24.64800 -44.80300 1.000 317.79157 ? 358 LYS F CD  1 
ATOM 2451 C CE  . LYS A 1 358 ? -38.56300 -25.14100 -45.84800 1.000 301.66362 ? 358 LYS F CE  1 
ATOM 2452 N NZ  . LYS A 1 358 ? -38.69800 -24.55100 -47.19500 1.000 301.34518 ? 358 LYS F NZ  1 
ATOM 2453 N N   . VAL A 1 359 ? -43.65600 -26.73300 -41.21200 1.000 339.51780 ? 359 VAL F N   1 
ATOM 2454 C CA  . VAL A 1 359 ? -44.36800 -26.93100 -39.95500 1.000 330.52220 ? 359 VAL F CA  1 
ATOM 2455 C C   . VAL A 1 359 ? -43.99600 -28.30000 -39.40400 1.000 334.85914 ? 359 VAL F C   1 
ATOM 2456 O O   . VAL A 1 359 ? -43.57500 -29.20200 -40.12600 1.000 342.33087 ? 359 VAL F O   1 
ATOM 2457 C CB  . VAL A 1 359 ? -45.90700 -26.89500 -40.08600 1.000 321.70702 ? 359 VAL F CB  1 
ATOM 2458 C CG1 . VAL A 1 359 ? -46.41400 -25.51300 -40.54000 1.000 313.86683 ? 359 VAL F CG1 1 
ATOM 2459 C CG2 . VAL A 1 359 ? -46.43200 -28.12200 -40.82700 1.000 321.67547 ? 359 VAL F CG2 1 
ATOM 2460 N N   . SER A 1 360 ? -44.22800 -28.46700 -38.11300 1.000 332.56984 ? 360 SER F N   1 
ATOM 2461 C CA  . SER A 1 360 ? -44.24800 -29.78000 -37.48900 1.000 338.63677 ? 360 SER F CA  1 
ATOM 2462 C C   . SER A 1 360 ? -45.64700 -30.09800 -36.98500 1.000 335.43370 ? 360 SER F C   1 
ATOM 2463 O O   . SER A 1 360 ? -46.50500 -29.20900 -36.84000 1.000 321.03997 ? 360 SER F O   1 
ATOM 2464 C CB  . SER A 1 360 ? -43.20200 -29.90400 -36.36800 1.000 337.77633 ? 360 SER F CB  1 
ATOM 2465 O OG  . SER A 1 360 ? -41.87800 -29.83300 -36.87600 1.000 321.76044 ? 360 SER F OG  1 
ATOM 2466 N N   . THR A 1 361 ? -45.86500 -31.39100 -36.72000 1.000 347.46911 ? 361 THR F N   1 
ATOM 2467 C CA  . THR A 1 361 ? -47.17000 -31.91200 -36.34700 1.000 338.89733 ? 361 THR F CA  1 
ATOM 2468 C C   . THR A 1 361 ? -47.07200 -32.78600 -35.08200 1.000 337.31930 ? 361 THR F C   1 
ATOM 2469 O O   . THR A 1 361 ? -46.01700 -33.36000 -34.78600 1.000 348.71734 ? 361 THR F O   1 
ATOM 2470 C CB  . THR A 1 361 ? -47.68600 -32.69700 -37.59500 1.000 337.58550 ? 361 THR F CB  1 
ATOM 2471 O OG1 . THR A 1 361 ? -46.89800 -33.87500 -37.82700 1.000 356.35414 ? 361 THR F OG1 1 
ATOM 2472 C CG2 . THR A 1 361 ? -47.58700 -31.84500 -38.83500 1.000 322.12996 ? 361 THR F CG2 1 
ATOM 2473 N N   . GLY A 1 362 ? -48.18700 -32.94900 -34.35000 1.000 313.81302 ? 362 GLY F N   1 
ATOM 2474 C CA  . GLY A 1 362 ? -48.17000 -33.85500 -33.20800 1.000 299.09483 ? 362 GLY F CA  1 
ATOM 2475 C C   . GLY A 1 362 ? -49.52500 -34.43200 -32.87700 1.000 298.07550 ? 362 GLY F C   1 
ATOM 2476 O O   . GLY A 1 362 ? -50.57700 -33.82200 -33.12200 1.000 295.11369 ? 362 GLY F O   1 
ATOM 2477 N N   . ARG A 1 363 ? -49.47000 -35.62800 -32.28500 1.000 307.89343 ? 363 ARG F N   1 
ATOM 2478 C CA  . ARG A 1 363 ? -50.51900 -36.50700 -31.75300 1.000 322.62563 ? 363 ARG F CA  1 
ATOM 2479 C C   . ARG A 1 363 ? -50.87200 -36.57500 -30.22700 1.000 327.33628 ? 363 ARG F C   1 
ATOM 2480 O O   . ARG A 1 363 ? -51.81600 -37.30100 -29.89000 1.000 321.08921 ? 363 ARG F O   1 
ATOM 2481 C CB  . ARG A 1 363 ? -50.11000 -37.84800 -32.34100 1.000 324.89101 ? 363 ARG F CB  1 
ATOM 2482 C CG  . ARG A 1 363 ? -50.37000 -37.77700 -33.85700 1.000 310.84570 ? 363 ARG F CG  1 
ATOM 2483 C CD  . ARG A 1 363 ? -50.03800 -39.03500 -34.58300 1.000 310.56019 ? 363 ARG F CD  1 
ATOM 2484 N NE  . ARG A 1 363 ? -48.59300 -39.19800 -34.49100 1.000 314.24086 ? 363 ARG F NE  1 
ATOM 2485 C CZ  . ARG A 1 363 ? -47.90000 -40.21500 -34.98300 1.000 320.21690 ? 363 ARG F CZ  1 
ATOM 2486 N NH1 . ARG A 1 363 ? -48.48800 -41.21400 -35.62200 1.000 322.37175 ? 363 ARG F NH1 1 
ATOM 2487 N NH2 . ARG A 1 363 ? -46.57900 -40.20400 -34.87200 1.000 323.23448 ? 363 ARG F NH2 1 
ATOM 2488 N N   . HIS A 1 364 ? -50.24400 -35.82900 -29.29900 1.000 330.33299 ? 364 HIS F N   1 
ATOM 2489 C CA  . HIS A 1 364 ? -50.52900 -35.96900 -27.80300 1.000 320.99926 ? 364 HIS F CA  1 
ATOM 2490 C C   . HIS A 1 364 ? -50.60000 -34.55100 -27.25600 1.000 325.21534 ? 364 HIS F C   1 
ATOM 2491 O O   . HIS A 1 364 ? -49.86600 -33.69700 -27.75900 1.000 342.75169 ? 364 HIS F O   1 
ATOM 2492 C CB  . HIS A 1 364 ? -49.40200 -36.62200 -26.96500 1.000 321.64573 ? 364 HIS F CB  1 
ATOM 2493 C CG  . HIS A 1 364 ? -49.00900 -38.01400 -27.34100 1.000 314.29630 ? 364 HIS F CG  1 
ATOM 2494 N ND1 . HIS A 1 364 ? -49.71500 -39.13900 -26.97800 1.000 311.38601 ? 364 HIS F ND1 1 
ATOM 2495 C CD2 . HIS A 1 364 ? -47.87300 -38.46000 -27.92900 1.000 310.40975 ? 364 HIS F CD2 1 
ATOM 2496 C CE1 . HIS A 1 364 ? -49.08000 -40.20900 -27.42300 1.000 309.93349 ? 364 HIS F CE1 1 
ATOM 2497 N NE2 . HIS A 1 364 ? -47.95100 -39.82600 -27.98500 1.000 308.47086 ? 364 HIS F NE2 1 
ATOM 2498 N N   . PRO A 1 365 ? -51.45100 -34.21800 -26.27700 1.000 310.70134 ? 365 PRO F N   1 
ATOM 2499 C CA  . PRO A 1 365 ? -51.59800 -32.78400 -25.95700 1.000 311.00530 ? 365 PRO F CA  1 
ATOM 2500 C C   . PRO A 1 365 ? -50.44700 -32.19500 -25.11400 1.000 314.36244 ? 365 PRO F C   1 
ATOM 2501 O O   . PRO A 1 365 ? -49.90700 -32.85000 -24.21200 1.000 320.40890 ? 365 PRO F O   1 
ATOM 2502 C CB  . PRO A 1 365 ? -52.91900 -32.76300 -25.17800 1.000 302.10052 ? 365 PRO F CB  1 
ATOM 2503 C CG  . PRO A 1 365 ? -52.97400 -34.12300 -24.49600 1.000 296.39298 ? 365 PRO F CG  1 
ATOM 2504 C CD  . PRO A 1 365 ? -52.34500 -35.08200 -25.47700 1.000 293.94151 ? 365 PRO F CD  1 
ATOM 2505 N N   . ILE A 1 366 ? -50.15300 -30.88200 -25.37500 1.000 303.84909 ? 366 ILE F N   1 
ATOM 2506 C CA  . ILE A 1 366 ? -49.24100 -29.94900 -24.66600 1.000 281.00079 ? 366 ILE F CA  1 
ATOM 2507 C C   . ILE A 1 366 ? -49.96800 -28.72500 -24.08200 1.000 275.26933 ? 366 ILE F C   1 
ATOM 2508 O O   . ILE A 1 366 ? -51.19600 -28.62500 -24.17500 1.000 279.14156 ? 366 ILE F O   1 
ATOM 2509 C CB  . ILE A 1 366 ? -48.13600 -29.47800 -25.65100 1.000 268.81076 ? 366 ILE F CB  1 
ATOM 2510 C CG1 . ILE A 1 366 ? -47.30000 -30.63400 -26.15200 1.000 272.56075 ? 366 ILE F CG1 1 
ATOM 2511 C CG2 . ILE A 1 366 ? -47.02400 -28.66800 -24.97600 1.000 257.43871 ? 366 ILE F CG2 1 
ATOM 2512 C CD1 . ILE A 1 366 ? -46.43300 -30.25000 -27.33700 1.000 262.32823 ? 366 ILE F CD1 1 
ATOM 2513 N N   . SER A 1 367 ? -49.20400 -27.75300 -23.53200 1.000 266.31113 ? 367 SER F N   1 
ATOM 2514 C CA  . SER A 1 367 ? -49.65900 -26.44700 -23.02800 1.000 260.49329 ? 367 SER F CA  1 
ATOM 2515 C C   . SER A 1 367 ? -48.50500 -25.48800 -22.70400 1.000 255.30402 ? 367 SER F C   1 
ATOM 2516 O O   . SER A 1 367 ? -47.52700 -25.91400 -22.07000 1.000 249.34090 ? 367 SER F O   1 
ATOM 2517 C CB  . SER A 1 367 ? -50.51700 -26.59100 -21.76700 1.000 263.03438 ? 367 SER F CB  1 
ATOM 2518 O OG  . SER A 1 367 ? -51.64400 -27.41000 -21.97500 1.000 268.72171 ? 367 SER F OG  1 
ATOM 2519 N N   . MET A 1 368 ? -48.55500 -24.23200 -23.19500 1.000 249.25782 ? 368 MET F N   1 
ATOM 2520 C CA  . MET A 1 368 ? -47.45000 -23.29400 -22.95700 1.000 248.04776 ? 368 MET F CA  1 
ATOM 2521 C C   . MET A 1 368 ? -47.84000 -21.84400 -23.28500 1.000 237.02060 ? 368 MET F C   1 
ATOM 2522 O O   . MET A 1 368 ? -48.95500 -21.55500 -23.72300 1.000 229.90901 ? 368 MET F O   1 
ATOM 2523 C CB  . MET A 1 368 ? -46.23400 -23.71100 -23.77000 1.000 249.94577 ? 368 MET F CB  1 
ATOM 2524 C CG  . MET A 1 368 ? -46.48600 -23.58000 -25.23400 1.000 247.64968 ? 368 MET F CG  1 
ATOM 2525 S SD  . MET A 1 368 ? -45.84800 -22.00200 -25.77900 1.000 243.83265 ? 368 MET F SD  1 
ATOM 2526 C CE  . MET A 1 368 ? -44.08200 -22.23000 -25.52200 1.000 242.15865 ? 368 MET F CE  1 
ATOM 2527 N N   . VAL A 1 369 ? -46.90200 -20.92800 -23.00500 1.000 237.83875 ? 369 VAL F N   1 
ATOM 2528 C CA  . VAL A 1 369 ? -47.00200 -19.49700 -23.30100 1.000 230.22216 ? 369 VAL F CA  1 
ATOM 2529 C C   . VAL A 1 369 ? -45.77400 -19.08200 -24.09800 1.000 230.02540 ? 369 VAL F C   1 
ATOM 2530 O O   . VAL A 1 369 ? -44.64700 -19.32400 -23.66100 1.000 232.85744 ? 369 VAL F O   1 
ATOM 2531 C CB  . VAL A 1 369 ? -47.06800 -18.60800 -22.04800 1.000 228.93961 ? 369 VAL F CB  1 
ATOM 2532 C CG1 . VAL A 1 369 ? -46.75200 -17.18700 -22.44100 1.000 232.23013 ? 369 VAL F CG1 1 
ATOM 2533 C CG2 . VAL A 1 369 ? -48.39700 -18.56100 -21.53000 1.000 223.01381 ? 369 VAL F CG2 1 
ATOM 2534 N N   . ALA A 1 370 ? -45.97500 -18.41400 -25.22500 1.000 229.65671 ? 370 ALA F N   1 
ATOM 2535 C CA  . ALA A 1 370 ? -44.87200 -17.80300 -25.96700 1.000 230.05912 ? 370 ALA F CA  1 
ATOM 2536 C C   . ALA A 1 370 ? -45.10200 -16.31100 -25.82900 1.000 228.47476 ? 370 ALA F C   1 
ATOM 2537 O O   . ALA A 1 370 ? -46.07500 -15.77100 -26.37000 1.000 229.30195 ? 370 ALA F O   1 
ATOM 2538 C CB  . ALA A 1 370 ? -44.80400 -18.24100 -27.42900 1.000 238.72644 ? 370 ALA F CB  1 
ATOM 2539 N N   . LEU A 1 371 ? -44.29400 -15.67600 -25.00100 1.000 228.01790 ? 371 LEU F N   1 
ATOM 2540 C CA  . LEU A 1 371 ? -44.43400 -14.24500 -24.81400 1.000 235.90914 ? 371 LEU F CA  1 
ATOM 2541 C C   . LEU A 1 371 ? -44.04700 -13.52700 -26.12100 1.000 236.06256 ? 371 LEU F C   1 
ATOM 2542 O O   . LEU A 1 371 ? -43.14100 -13.97900 -26.83500 1.000 227.45012 ? 371 LEU F O   1 
ATOM 2543 C CB  . LEU A 1 371 ? -43.56900 -13.84500 -23.59400 1.000 245.10176 ? 371 LEU F CB  1 
ATOM 2544 C CG  . LEU A 1 371 ? -44.00500 -14.40400 -22.19100 1.000 240.66326 ? 371 LEU F CG  1 
ATOM 2545 C CD1 . LEU A 1 371 ? -42.99400 -14.29900 -20.98600 1.000 228.03794 ? 371 LEU F CD1 1 
ATOM 2546 C CD2 . LEU A 1 371 ? -45.32100 -13.79200 -21.75000 1.000 241.21628 ? 371 LEU F CD2 1 
ATOM 2547 N N   . SER A 1 372 ? -44.82100 -12.45300 -26.48700 1.000 238.35406 ? 372 SER F N   1 
ATOM 2548 C CA  . SER A 1 372 ? -44.69100 -11.52300 -27.63500 1.000 233.46691 ? 372 SER F CA  1 
ATOM 2549 C C   . SER A 1 372 ? -44.36700 -10.08100 -27.20300 1.000 234.17693 ? 372 SER F C   1 
ATOM 2550 O O   . SER A 1 372 ? -44.76900 -9.65000  -26.11400 1.000 240.77835 ? 372 SER F O   1 
ATOM 2551 C CB  . SER A 1 372 ? -45.96400 -11.52300 -28.50200 1.000 235.16862 ? 372 SER F CB  1 
ATOM 2552 O OG  . SER A 1 372 ? -46.23500 -12.81800 -29.01600 1.000 235.82696 ? 372 SER F OG  1 
ATOM 2553 N N   . PRO A 1 373 ? -43.88100 -9.24200  -28.13700 1.000 223.60121 ? 373 PRO F N   1 
ATOM 2554 C CA  . PRO A 1 373 ? -43.59400 -7.82300  -27.80600 1.000 228.30738 ? 373 PRO F CA  1 
ATOM 2555 C C   . PRO A 1 373 ? -44.70800 -7.02700  -27.16300 1.000 230.03953 ? 373 PRO F C   1 
ATOM 2556 O O   . PRO A 1 373 ? -44.42700 -6.14500  -26.34600 1.000 234.82988 ? 373 PRO F O   1 
ATOM 2557 C CB  . PRO A 1 373 ? -43.23900 -7.23200  -29.16800 1.000 224.03033 ? 373 PRO F CB  1 
ATOM 2558 C CG  . PRO A 1 373 ? -42.66700 -8.36100  -29.90000 1.000 229.87443 ? 373 PRO F CG  1 
ATOM 2559 C CD  . PRO A 1 373 ? -43.42100 -9.58400  -29.49000 1.000 223.58904 ? 373 PRO F CD  1 
ATOM 2560 N N   . LEU A 1 374 ? -45.94600 -7.23400  -27.54700 1.000 227.47539 ? 374 LEU F N   1 
ATOM 2561 C CA  . LEU A 1 374 ? -47.01100 -6.43700  -26.96600 1.000 230.82435 ? 374 LEU F CA  1 
ATOM 2562 C C   . LEU A 1 374 ? -48.01200 -7.34200  -26.27000 1.000 236.88426 ? 374 LEU F C   1 
ATOM 2563 O O   . LEU A 1 374 ? -49.17600 -6.96900  -26.11400 1.000 238.90938 ? 374 LEU F O   1 
ATOM 2564 C CB  . LEU A 1 374 ? -47.66200 -5.47500  -27.96200 1.000 227.44035 ? 374 LEU F CB  1 
ATOM 2565 C CG  . LEU A 1 374 ? -46.69100 -4.55000  -28.70900 1.000 229.63157 ? 374 LEU F CG  1 
ATOM 2566 C CD1 . LEU A 1 374 ? -47.47600 -3.58000  -29.55400 1.000 240.22572 ? 374 LEU F CD1 1 
ATOM 2567 C CD2 . LEU A 1 374 ? -45.81500 -3.76900  -27.74300 1.000 232.31357 ? 374 LEU F CD2 1 
ATOM 2568 N N   . GLY A 1 375 ? -47.60100 -8.57200  -25.94600 1.000 236.05445 ? 375 GLY F N   1 
ATOM 2569 C CA  . GLY A 1 375 ? -48.50600 -9.49600  -25.28200 1.000 231.45304 ? 375 GLY F CA  1 
ATOM 2570 C C   . GLY A 1 375 ? -47.94200 -10.88800 -25.12500 1.000 224.52779 ? 375 GLY F C   1 
ATOM 2571 O O   . GLY A 1 375 ? -46.76400 -11.07200 -24.82000 1.000 220.55751 ? 375 GLY F O   1 
ATOM 2572 N N   . ALA A 1 376 ? -48.81900 -11.87800 -25.24800 1.000 223.70962 ? 376 ALA F N   1 
ATOM 2573 C CA  . ALA A 1 376 ? -48.45200 -13.27800 -25.09400 1.000 218.58931 ? 376 ALA F CA  1 
ATOM 2574 C C   . ALA A 1 376 ? -49.47500 -14.14200 -25.81100 1.000 215.20608 ? 376 ALA F C   1 
ATOM 2575 O O   . ALA A 1 376 ? -50.68100 -13.89000 -25.72000 1.000 220.38902 ? 376 ALA F O   1 
ATOM 2576 C CB  . ALA A 1 376 ? -48.36600 -13.67900 -23.62200 1.000 222.20990 ? 376 ALA F CB  1 
ATOM 2577 N N   . LEU A 1 377 ? -48.99800 -15.16100 -26.51200 1.000 209.92247 ? 377 LEU F N   1 
ATOM 2578 C CA  . LEU A 1 377 ? -49.91100 -16.16000 -27.00900 1.000 212.03903 ? 377 LEU F CA  1 
ATOM 2579 C C   . LEU A 1 377 ? -49.89100 -17.21700 -25.92700 1.000 221.85423 ? 377 LEU F C   1 
ATOM 2580 O O   . LEU A 1 377 ? -48.81700 -17.67000 -25.51300 1.000 222.20727 ? 377 LEU F O   1 
ATOM 2581 C CB  . LEU A 1 377 ? -49.48000 -16.69500 -28.36600 1.000 212.22311 ? 377 LEU F CB  1 
ATOM 2582 C CG  . LEU A 1 377 ? -49.64400 -15.67000 -29.47500 1.000 214.13319 ? 377 LEU F CG  1 
ATOM 2583 C CD1 . LEU A 1 377 ? -48.81700 -16.05100 -30.67000 1.000 221.65128 ? 377 LEU F CD1 1 
ATOM 2584 C CD2 . LEU A 1 377 ? -51.10000 -15.56900 -29.84400 1.000 221.25907 ? 377 LEU F CD2 1 
ATOM 2585 N N   . VAL A 1 378 ? -51.05900 -17.53600 -25.40000 1.000 230.04720 ? 378 VAL F N   1 
ATOM 2586 C CA  . VAL A 1 378 ? -51.17800 -18.50500 -24.32000 1.000 235.65413 ? 378 VAL F CA  1 
ATOM 2587 C C   . VAL A 1 378 ? -52.02000 -19.67200 -24.81600 1.000 242.27757 ? 378 VAL F C   1 
ATOM 2588 O O   . VAL A 1 378 ? -53.21500 -19.50400 -25.11700 1.000 250.00602 ? 378 VAL F O   1 
ATOM 2589 C CB  . VAL A 1 378 ? -51.75600 -17.87600 -23.04400 1.000 238.04669 ? 378 VAL F CB  1 
ATOM 2590 C CG1 . VAL A 1 378 ? -51.67500 -18.84600 -21.89300 1.000 239.60397 ? 378 VAL F CG1 1 
ATOM 2591 C CG2 . VAL A 1 378 ? -50.98400 -16.61400 -22.69600 1.000 226.59750 ? 378 VAL F CG2 1 
ATOM 2592 N N   . ALA A 1 379 ? -51.37800 -20.82200 -25.00500 1.000 231.69738 ? 379 ALA F N   1 
ATOM 2593 C CA  . ALA A 1 379 ? -52.07900 -22.06100 -25.29300 1.000 235.18399 ? 379 ALA F CA  1 
ATOM 2594 C C   . ALA A 1 379 ? -52.28600 -22.76900 -23.96500 1.000 237.23766 ? 379 ALA F C   1 
ATOM 2595 O O   . ALA A 1 379 ? -51.36300 -23.38300 -23.42900 1.000 235.99551 ? 379 ALA F O   1 
ATOM 2596 C CB  . ALA A 1 379 ? -51.28500 -22.90600 -26.27200 1.000 240.19561 ? 379 ALA F CB  1 
ATOM 2597 N N   . CYS A 1 380 ? -53.51400 -22.71500 -23.45900 1.000 245.71560 ? 380 CYS F N   1 
ATOM 2598 C CA  . CYS A 1 380 ? -53.90500 -23.22800 -22.14600 1.000 256.05792 ? 380 CYS F CA  1 
ATOM 2599 C C   . CYS A 1 380 ? -54.88800 -24.35600 -22.33500 1.000 265.43806 ? 380 CYS F C   1 
ATOM 2600 O O   . CYS A 1 380 ? -56.03800 -24.11200 -22.68700 1.000 270.58944 ? 380 CYS F O   1 
ATOM 2601 C CB  . CYS A 1 380 ? -54.55600 -22.16500 -21.26300 1.000 259.62960 ? 380 CYS F CB  1 
ATOM 2602 S SG  . CYS A 1 380 ? -54.63100 -22.60900 -19.47300 1.000 250.21466 ? 380 CYS F SG  1 
ATOM 2603 N N   . TYR A 1 381 ? -54.47300 -25.56900 -22.04400 1.000 271.51408 ? 381 TYR F N   1 
ATOM 2604 C CA  . TYR A 1 381 ? -55.30900 -26.72800 -22.31000 1.000 285.38992 ? 381 TYR F CA  1 
ATOM 2605 C C   . TYR A 1 381 ? -55.58900 -27.50500 -21.03200 1.000 289.35633 ? 381 TYR F C   1 
ATOM 2606 O O   . TYR A 1 381 ? -55.15600 -27.12700 -19.93300 1.000 281.67485 ? 381 TYR F O   1 
ATOM 2607 C CB  . TYR A 1 381 ? -54.64700 -27.60200 -23.38100 1.000 285.92967 ? 381 TYR F CB  1 
ATOM 2608 C CG  . TYR A 1 381 ? -54.51600 -26.84100 -24.66300 1.000 275.46833 ? 381 TYR F CG  1 
ATOM 2609 C CD1 . TYR A 1 381 ? -55.65200 -26.42600 -25.33900 1.000 281.84493 ? 381 TYR F CD1 1 
ATOM 2610 C CD2 . TYR A 1 381 ? -53.28700 -26.40600 -25.12100 1.000 265.60983 ? 381 TYR F CD2 1 
ATOM 2611 C CE1 . TYR A 1 381 ? -55.57300 -25.68400 -26.49200 1.000 279.13358 ? 381 TYR F CE1 1 
ATOM 2612 C CE2 . TYR A 1 381 ? -53.19500 -25.65500 -26.27500 1.000 265.14596 ? 381 TYR F CE2 1 
ATOM 2613 C CZ  . TYR A 1 381 ? -54.34700 -25.28800 -26.95800 1.000 271.04856 ? 381 TYR F CZ  1 
ATOM 2614 O OH  . TYR A 1 381 ? -54.30000 -24.54000 -28.12200 1.000 267.37645 ? 381 TYR F OH  1 
ATOM 2615 N N   . LYS A 1 382 ? -56.40700 -28.55500 -21.19200 1.000 295.52417 ? 382 LYS F N   1 
ATOM 2616 C CA  . LYS A 1 382 ? -56.85800 -29.33900 -20.05500 1.000 291.25172 ? 382 LYS F CA  1 
ATOM 2617 C C   . LYS A 1 382 ? -55.61200 -29.87900 -19.38100 1.000 298.40017 ? 382 LYS F C   1 
ATOM 2618 O O   . LYS A 1 382 ? -54.73000 -30.44200 -20.03800 1.000 301.80457 ? 382 LYS F O   1 
ATOM 2619 C CB  . LYS A 1 382 ? -57.74500 -30.48900 -20.54700 1.000 282.10190 ? 382 LYS F CB  1 
ATOM 2620 C CG  . LYS A 1 382 ? -58.66800 -30.07200 -21.69600 1.000 284.57462 ? 382 LYS F CG  1 
ATOM 2621 C CD  . LYS A 1 382 ? -59.83400 -31.01600 -21.95000 1.000 291.03801 ? 382 LYS F CD  1 
ATOM 2622 C CE  . LYS A 1 382 ? -60.61000 -30.58800 -23.20800 1.000 292.19931 ? 382 LYS F CE  1 
ATOM 2623 N NZ  . LYS A 1 382 ? -59.80100 -30.69800 -24.45200 1.000 286.68582 ? 382 LYS F NZ  1 
ATOM 2624 N N   . GLY A 1 383 ? -55.54600 -29.71700 -18.07300 1.000 298.61857 ? 383 GLY F N   1 
ATOM 2625 C CA  . GLY A 1 383 ? -54.43300 -30.17400 -17.27300 1.000 294.29706 ? 383 GLY F CA  1 
ATOM 2626 C C   . GLY A 1 383 ? -53.67000 -29.03300 -16.64400 1.000 281.90921 ? 383 GLY F C   1 
ATOM 2627 O O   . GLY A 1 383 ? -52.85800 -29.27000 -15.73300 1.000 274.98160 ? 383 GLY F O   1 
ATOM 2628 N N   . VAL A 1 384 ? -53.82100 -27.81400 -17.17700 1.000 275.32883 ? 384 VAL F N   1 
ATOM 2629 C CA  . VAL A 1 384 ? -53.14800 -26.66500 -16.60400 1.000 260.22722 ? 384 VAL F CA  1 
ATOM 2630 C C   . VAL A 1 384 ? -54.19200 -25.57000 -16.42000 1.000 256.70075 ? 384 VAL F C   1 
ATOM 2631 O O   . VAL A 1 384 ? -55.23500 -25.55600 -17.08200 1.000 256.24611 ? 384 VAL F O   1 
ATOM 2632 C CB  . VAL A 1 384 ? -51.98600 -26.18500 -17.49600 1.000 251.96406 ? 384 VAL F CB  1 
ATOM 2633 C CG1 . VAL A 1 384 ? -51.09200 -27.34800 -17.86400 1.000 264.57620 ? 384 VAL F CG1 1 
ATOM 2634 C CG2 . VAL A 1 384 ? -52.55100 -25.60000 -18.76800 1.000 250.82856 ? 384 VAL F CG2 1 
ATOM 2635 N N   . SER A 1 385 ? -53.84400 -24.58800 -15.58800 1.000 252.73661 ? 385 SER F N   1 
ATOM 2636 C CA  . SER A 1 385 ? -54.64700 -23.39300 -15.36200 1.000 250.19652 ? 385 SER F CA  1 
ATOM 2637 C C   . SER A 1 385 ? -53.79300 -22.17100 -15.64400 1.000 246.58279 ? 385 SER F C   1 
ATOM 2638 O O   . SER A 1 385 ? -52.64500 -22.07400 -15.19400 1.000 246.33192 ? 385 SER F O   1 
ATOM 2639 C CB  . SER A 1 385 ? -55.27100 -23.33100 -13.95400 1.000 250.93471 ? 385 SER F CB  1 
ATOM 2640 O OG  . SER A 1 385 ? -54.30800 -23.44900 -12.92700 1.000 256.26726 ? 385 SER F OG  1 
ATOM 2641 N N   . CYS A 1 386 ? -54.37600 -21.23000 -16.34600 1.000 241.41214 ? 386 CYS F N   1 
ATOM 2642 C CA  . CYS A 1 386 ? -53.68600 -20.03700 -16.77500 1.000 237.28965 ? 386 CYS F CA  1 
ATOM 2643 C C   . CYS A 1 386 ? -54.52800 -18.85400 -16.36300 1.000 240.48752 ? 386 CYS F C   1 
ATOM 2644 O O   . CYS A 1 386 ? -55.75400 -18.92500 -16.36400 1.000 242.38262 ? 386 CYS F O   1 
ATOM 2645 C CB  . CYS A 1 386 ? -53.46100 -20.09000 -18.23500 1.000 239.39712 ? 386 CYS F CB  1 
ATOM 2646 S SG  . CYS A 1 386 ? -52.95300 -21.73200 -18.69300 1.000 259.66155 ? 386 CYS F SG  1 
ATOM 2647 N N   . SER A 1 387 ? -53.86500 -17.77000 -16.00800 1.000 240.84563 ? 387 SER F N   1 
ATOM 2648 C CA  . SER A 1 387 ? -54.58300 -16.58100 -15.58900 1.000 245.55040 ? 387 SER F CA  1 
ATOM 2649 C C   . SER A 1 387 ? -53.76900 -15.36900 -16.02000 1.000 242.93073 ? 387 SER F C   1 
ATOM 2650 O O   . SER A 1 387 ? -52.63700 -15.51000 -16.49800 1.000 241.40497 ? 387 SER F O   1 
ATOM 2651 C CB  . SER A 1 387 ? -54.76500 -16.65500 -14.04100 1.000 238.25307 ? 387 SER F CB  1 
ATOM 2652 O OG  . SER A 1 387 ? -55.56500 -15.65200 -13.43300 1.000 231.29566 ? 387 SER F OG  1 
ATOM 2653 N N   . ILE A 1 388 ? -54.39600 -14.18200 -15.97100 1.000 238.87543 ? 388 ILE F N   1 
ATOM 2654 C CA  . ILE A 1 388 ? -53.68100 -12.92800 -16.18000 1.000 225.76352 ? 388 ILE F CA  1 
ATOM 2655 C C   . ILE A 1 388 ? -53.92500 -12.12700 -14.92500 1.000 223.55768 ? 388 ILE F C   1 
ATOM 2656 O O   . ILE A 1 388 ? -55.01700 -12.18500 -14.34600 1.000 226.21617 ? 388 ILE F O   1 
ATOM 2657 C CB  . ILE A 1 388 ? -54.13500 -12.04000 -17.35200 1.000 211.45569 ? 388 ILE F CB  1 
ATOM 2658 C CG1 . ILE A 1 388 ? -55.57500 -11.59000 -17.17200 1.000 204.77670 ? 388 ILE F CG1 1 
ATOM 2659 C CG2 . ILE A 1 388 ? -54.03500 -12.79300 -18.63100 1.000 216.91489 ? 388 ILE F CG2 1 
ATOM 2660 C CD1 . ILE A 1 388 ? -56.01700 -10.76300 -18.28900 1.000 209.38264 ? 388 ILE F CD1 1 
ATOM 2661 N N   . GLY A 1 389 ? -52.92900 -11.36600 -14.51300 1.000 220.86690 ? 389 GLY F N   1 
ATOM 2662 C CA  . GLY A 1 389 ? -53.02900 -10.65000 -13.27600 1.000 226.63316 ? 389 GLY F CA  1 
ATOM 2663 C C   . GLY A 1 389 ? -52.62900 -9.22400  -13.56800 1.000 229.98791 ? 389 GLY F C   1 
ATOM 2664 O O   . GLY A 1 389 ? -51.93600 -8.93600  -14.55100 1.000 225.44705 ? 389 GLY F O   1 
ATOM 2665 N N   . SER A 1 390 ? -53.00600 -8.34900  -12.64900 1.000 237.50733 ? 390 SER F N   1 
ATOM 2666 C CA  . SER A 1 390 ? -52.62400 -6.96300  -12.77400 1.000 241.15394 ? 390 SER F CA  1 
ATOM 2667 C C   . SER A 1 390 ? -51.94000 -6.49800  -11.51500 1.000 239.81806 ? 390 SER F C   1 
ATOM 2668 O O   . SER A 1 390 ? -52.31700 -6.85000  -10.39000 1.000 234.96854 ? 390 SER F O   1 
ATOM 2669 C CB  . SER A 1 390 ? -53.80300 -6.01600  -13.08000 1.000 246.15787 ? 390 SER F CB  1 
ATOM 2670 O OG  . SER A 1 390 ? -53.48200 -4.65400  -12.78100 1.000 245.57760 ? 390 SER F OG  1 
ATOM 2671 N N   . ASN A 1 391 ? -50.93300 -5.68600  -11.74500 1.000 246.76883 ? 391 ASN F N   1 
ATOM 2672 C CA  . ASN A 1 391 ? -50.18900 -5.09800  -10.66800 1.000 257.71526 ? 391 ASN F CA  1 
ATOM 2673 C C   . ASN A 1 391 ? -51.05700 -4.03600  -9.98000  1.000 258.57848 ? 391 ASN F C   1 
ATOM 2674 O O   . ASN A 1 391 ? -50.79200 -3.67900  -8.82700  1.000 264.29750 ? 391 ASN F O   1 
ATOM 2675 C CB  . ASN A 1 391 ? -48.83800 -4.63600  -11.24200 1.000 260.90184 ? 391 ASN F CB  1 
ATOM 2676 C CG  . ASN A 1 391 ? -47.94600 -5.85400  -11.71800 1.000 248.60659 ? 391 ASN F CG  1 
ATOM 2677 O OD1 . ASN A 1 391 ? -48.04300 -6.96200  -11.17500 1.000 245.68693 ? 391 ASN F OD1 1 
ATOM 2678 N ND2 . ASN A 1 391 ? -47.09600 -5.63100  -12.72700 1.000 235.83084 ? 391 ASN F ND2 1 
ATOM 2679 N N   . ARG A 1 392 ? -52.10400 -3.54400  -10.66400 1.000 253.87969 ? 392 ARG F N   1 
ATOM 2680 C CA  . ARG A 1 392 ? -53.04100 -2.58400  -10.08900 1.000 255.38216 ? 392 ARG F CA  1 
ATOM 2681 C C   . ARG A 1 392 ? -54.33000 -3.22400  -9.54200  1.000 250.42488 ? 392 ARG F C   1 
ATOM 2682 O O   . ARG A 1 392 ? -54.79400 -2.82500  -8.47000  1.000 250.39057 ? 392 ARG F O   1 
ATOM 2683 C CB  . ARG A 1 392 ? -53.39800 -1.56800  -11.19500 1.000 258.50706 ? 392 ARG F CB  1 
ATOM 2684 C CG  . ARG A 1 392 ? -52.18300 -0.81300  -11.87000 1.000 256.27738 ? 392 ARG F CG  1 
ATOM 2685 C CD  . ARG A 1 392 ? -51.57000 0.29200   -10.97800 1.000 267.92724 ? 392 ARG F CD  1 
ATOM 2686 N NE  . ARG A 1 392 ? -52.46900 1.43500   -10.76800 1.000 286.13605 ? 392 ARG F NE  1 
ATOM 2687 C CZ  . ARG A 1 392 ? -52.47500 2.56800   -11.47200 1.000 287.00314 ? 392 ARG F CZ  1 
ATOM 2688 N NH1 . ARG A 1 392 ? -51.61700 2.78200   -12.46100 1.000 280.03979 ? 392 ARG F NH1 1 
ATOM 2689 N NH2 . ARG A 1 392 ? -53.39200 3.49800   -11.20000 1.000 291.26568 ? 392 ARG F NH2 1 
ATOM 2690 N N   . VAL A 1 393 ? -54.94800 -4.17300  -10.25300 1.000 246.56771 ? 393 VAL F N   1 
ATOM 2691 C CA  . VAL A 1 393 ? -56.28100 -4.67400  -9.90400  1.000 244.89381 ? 393 VAL F CA  1 
ATOM 2692 C C   . VAL A 1 393 ? -56.23300 -6.07600  -9.29500  1.000 241.76629 ? 393 VAL F C   1 
ATOM 2693 O O   . VAL A 1 393 ? -57.26300 -6.54200  -8.77500  1.000 245.62295 ? 393 VAL F O   1 
ATOM 2694 C CB  . VAL A 1 393 ? -57.26100 -4.64000  -11.08700 1.000 243.44113 ? 393 VAL F CB  1 
ATOM 2695 C CG1 . VAL A 1 393 ? -57.26500 -3.23800  -11.71900 1.000 241.89236 ? 393 VAL F CG1 1 
ATOM 2696 C CG2 . VAL A 1 393 ? -57.01200 -5.79100  -12.02800 1.000 239.43599 ? 393 VAL F CG2 1 
ATOM 2697 N N   . GLY A 1 394 ? -55.16100 -6.82500  -9.55800  1.000 236.55821 ? 394 GLY F N   1 
ATOM 2698 C CA  . GLY A 1 394 ? -54.87000 -8.16900  -9.10300  1.000 233.64536 ? 394 GLY F CA  1 
ATOM 2699 C C   . GLY A 1 394 ? -55.24800 -9.16200  -10.18100 1.000 234.40057 ? 394 GLY F C   1 
ATOM 2700 O O   . GLY A 1 394 ? -55.23900 -8.75600  -11.34000 1.000 236.43118 ? 394 GLY F O   1 
ATOM 2701 N N   . ILE A 1 395 ? -55.64600 -10.40500 -9.87900  1.000 232.16279 ? 395 ILE F N   1 
ATOM 2702 C CA  . ILE A 1 395 ? -55.98200 -11.33200 -10.96600 1.000 232.65958 ? 395 ILE F CA  1 
ATOM 2703 C C   . ILE A 1 395 ? -57.28200 -10.86600 -11.59700 1.000 234.56123 ? 395 ILE F C   1 
ATOM 2704 O O   . ILE A 1 395 ? -58.25800 -10.54700 -10.89100 1.000 230.06579 ? 395 ILE F O   1 
ATOM 2705 C CB  . ILE A 1 395 ? -56.03000 -12.83900 -10.63200 1.000 226.87943 ? 395 ILE F CB  1 
ATOM 2706 C CG1 . ILE A 1 395 ? -56.92500 -13.26400 -9.51000  1.000 226.57783 ? 395 ILE F CG1 1 
ATOM 2707 C CG2 . ILE A 1 395 ? -54.61700 -13.45700 -10.50400 1.000 218.14188 ? 395 ILE F CG2 1 
ATOM 2708 C CD1 . ILE A 1 395 ? -56.96600 -14.78700 -9.57800  1.000 222.13962 ? 395 ILE F CD1 1 
ATOM 2709 N N   . ILE A 1 396 ? -57.25300 -10.69800 -12.91800 1.000 234.96563 ? 396 ILE F N   1 
ATOM 2710 C CA  . ILE A 1 396 ? -58.41300 -10.16500 -13.59600 1.000 235.73588 ? 396 ILE F CA  1 
ATOM 2711 C C   . ILE A 1 396 ? -59.43600 -11.28000 -13.80100 1.000 248.44688 ? 396 ILE F C   1 
ATOM 2712 O O   . ILE A 1 396 ? -60.58900 -11.15100 -13.37200 1.000 264.84782 ? 396 ILE F O   1 
ATOM 2713 C CB  . ILE A 1 396 ? -57.97600 -9.59600  -14.96900 1.000 224.36296 ? 396 ILE F CB  1 
ATOM 2714 C CG1 . ILE A 1 396 ? -56.89100 -8.53200  -14.86400 1.000 222.12683 ? 396 ILE F CG1 1 
ATOM 2715 C CG2 . ILE A 1 396 ? -59.16000 -9.02500  -15.69800 1.000 228.98530 ? 396 ILE F CG2 1 
ATOM 2716 C CD1 . ILE A 1 396 ? -56.24600 -8.18900  -16.19300 1.000 211.50834 ? 396 ILE F CD1 1 
ATOM 2717 N N   . LYS A 1 397 ? -58.99700 -12.44200 -14.29300 1.000 242.86964 ? 397 LYS F N   1 
ATOM 2718 C CA  . LYS A 1 397 ? -59.82600 -13.49500 -14.88500 1.000 239.25604 ? 397 LYS F CA  1 
ATOM 2719 C C   . LYS A 1 397 ? -58.90700 -14.67200 -15.17400 1.000 239.04596 ? 397 LYS F C   1 
ATOM 2720 O O   . LYS A 1 397 ? -57.75000 -14.46500 -15.54600 1.000 239.45685 ? 397 LYS F O   1 
ATOM 2721 C CB  . LYS A 1 397 ? -60.59400 -13.00300 -16.13500 1.000 238.86506 ? 397 LYS F CB  1 
ATOM 2722 C CG  . LYS A 1 397 ? -61.86300 -12.13500 -15.76700 1.000 253.17705 ? 397 LYS F CG  1 
ATOM 2723 C CD  . LYS A 1 397 ? -62.57000 -11.35400 -16.92800 1.000 261.18306 ? 397 LYS F CD  1 
ATOM 2724 C CE  . LYS A 1 397 ? -63.66800 -10.34600 -16.40600 1.000 254.33260 ? 397 LYS F CE  1 
ATOM 2725 N NZ  . LYS A 1 397 ? -64.37700 -9.47400  -17.42700 1.000 244.20886 ? 397 LYS F NZ  1 
ATOM 2726 N N   . GLN A 1 398 ? -59.41900 -15.89600 -15.04200 1.000 239.62148 ? 398 GLN F N   1 
ATOM 2727 C CA  . GLN A 1 398 ? -58.61100 -17.03500 -15.46800 1.000 246.41749 ? 398 GLN F CA  1 
ATOM 2728 C C   . GLN A 1 398 ? -58.84000 -17.05500 -16.98000 1.000 253.11869 ? 398 GLN F C   1 
ATOM 2729 O O   . GLN A 1 398 ? -59.92200 -16.69200 -17.44600 1.000 254.68560 ? 398 GLN F O   1 
ATOM 2730 C CB  . GLN A 1 398 ? -59.08700 -18.29800 -14.69200 1.000 236.85259 ? 398 GLN F CB  1 
ATOM 2731 C CG  . GLN A 1 398 ? -58.21800 -19.62800 -14.47300 1.000 226.70245 ? 398 GLN F CG  1 
ATOM 2732 C CD  . GLN A 1 398 ? -57.98000 -20.60500 -15.61000 1.000 229.24285 ? 398 GLN F CD  1 
ATOM 2733 O OE1 . GLN A 1 398 ? -56.95500 -21.26900 -15.62600 1.000 228.89641 ? 398 GLN F OE1 1 
ATOM 2734 N NE2 . GLN A 1 398 ? -58.97900 -20.82800 -16.44300 1.000 232.95954 ? 398 GLN F NE2 1 
ATOM 2735 N N   . LEU A 1 399 ? -57.78800 -17.38300 -17.75100 1.000 255.73702 ? 399 LEU F N   1 
ATOM 2736 C CA  . LEU A 1 399 ? -57.80500 -17.38200 -19.22500 1.000 259.41575 ? 399 LEU F CA  1 
ATOM 2737 C C   . LEU A 1 399 ? -58.22300 -18.72600 -19.84800 1.000 257.35576 ? 399 LEU F C   1 
ATOM 2738 O O   . LEU A 1 399 ? -57.97800 -19.80000 -19.28100 1.000 253.29261 ? 399 LEU F O   1 
ATOM 2739 C CB  . LEU A 1 399 ? -56.45600 -16.88800 -19.77600 1.000 258.07803 ? 399 LEU F CB  1 
ATOM 2740 C CG  . LEU A 1 399 ? -55.12000 -17.58000 -19.54400 1.000 248.69187 ? 399 LEU F CG  1 
ATOM 2741 C CD1 . LEU A 1 399 ? -54.95500 -18.52300 -20.73000 1.000 256.87806 ? 399 LEU F CD1 1 
ATOM 2742 C CD2 . LEU A 1 399 ? -53.90300 -16.65100 -19.35200 1.000 231.10568 ? 399 LEU F CD2 1 
ATOM 2743 N N   . ASN A 1 400 ? -58.82300 -18.65100 -21.05000 1.000 261.11467 ? 400 ASN F N   1 
ATOM 2744 C CA  . ASN A 1 400 ? -59.68700 -19.70800 -21.55700 1.000 262.28104 ? 400 ASN F CA  1 
ATOM 2745 C C   . ASN A 1 400 ? -58.90800 -20.88900 -22.10500 1.000 254.98266 ? 400 ASN F C   1 
ATOM 2746 O O   . ASN A 1 400 ? -57.74400 -20.76000 -22.52500 1.000 253.70747 ? 400 ASN F O   1 
ATOM 2747 C CB  . ASN A 1 400 ? -60.48100 -19.17200 -22.77300 1.000 267.01188 ? 400 ASN F CB  1 
ATOM 2748 C CG  . ASN A 1 400 ? -61.43600 -18.03700 -22.44800 1.000 269.45753 ? 400 ASN F CG  1 
ATOM 2749 O OD1 . ASN A 1 400 ? -62.14400 -18.08500 -21.44900 1.000 273.17967 ? 400 ASN F OD1 1 
ATOM 2750 N ND2 . ASN A 1 400 ? -61.43000 -16.99000 -23.27600 1.000 265.34558 ? 400 ASN F ND2 1 
ATOM 2751 N N   . LYS A 1 401 ? -59.56100 -22.05900 -22.07900 1.000 254.56582 ? 401 LYS F N   1 
ATOM 2752 C CA  . LYS A 1 401 ? -58.92200 -23.20100 -22.68900 1.000 259.51407 ? 401 LYS F CA  1 
ATOM 2753 C C   . LYS A 1 401 ? -58.86800 -22.85800 -24.17700 1.000 269.09875 ? 401 LYS F C   1 
ATOM 2754 O O   . LYS A 1 401 ? -59.81900 -22.29700 -24.72300 1.000 272.60966 ? 401 LYS F O   1 
ATOM 2755 C CB  . LYS A 1 401 ? -59.70500 -24.48800 -22.39500 1.000 260.07148 ? 401 LYS F CB  1 
ATOM 2756 C CG  . LYS A 1 401 ? -59.11800 -25.41900 -21.30200 1.000 258.66550 ? 401 LYS F CG  1 
ATOM 2757 C CD  . LYS A 1 401 ? -58.45000 -24.69500 -20.14600 1.000 254.40024 ? 401 LYS F CD  1 
ATOM 2758 C CE  . LYS A 1 401 ? -58.20300 -25.60900 -18.95800 1.000 255.16084 ? 401 LYS F CE  1 
ATOM 2759 N NZ  . LYS A 1 401 ? -57.39700 -24.90700 -17.92200 1.000 252.74200 ? 401 LYS F NZ  1 
ATOM 2760 N N   . GLY A 1 402 ? -57.78200 -23.17500 -24.85600 1.000 275.80126 ? 402 GLY F N   1 
ATOM 2761 C CA  . GLY A 1 402 ? -57.74500 -22.77700 -26.24800 1.000 276.17540 ? 402 GLY F CA  1 
ATOM 2762 C C   . GLY A 1 402 ? -56.60100 -21.83300 -26.47500 1.000 270.20514 ? 402 GLY F C   1 
ATOM 2763 O O   . GLY A 1 402 ? -55.75300 -21.62800 -25.60300 1.000 263.21176 ? 402 GLY F O   1 
ATOM 2764 N N   . CYS A 1 403 ? -56.58300 -21.23700 -27.66100 1.000 270.79039 ? 403 CYS F N   1 
ATOM 2765 C CA  . CYS A 1 403 ? -55.57700 -20.23500 -27.97400 1.000 268.27051 ? 403 CYS F CA  1 
ATOM 2766 C C   . CYS A 1 403 ? -56.06600 -18.80500 -27.69500 1.000 262.98138 ? 403 CYS F C   1 
ATOM 2767 O O   . CYS A 1 403 ? -57.06400 -18.35700 -28.27800 1.000 266.30766 ? 403 CYS F O   1 
ATOM 2768 C CB  . CYS A 1 403 ? -55.19200 -20.37400 -29.44300 1.000 278.47338 ? 403 CYS F CB  1 
ATOM 2769 S SG  . CYS A 1 403 ? -54.08500 -19.06700 -29.99800 1.000 309.59539 ? 403 CYS F SG  1 
ATOM 2770 N N   . SER A 1 404 ? -55.37800 -18.08300 -26.79900 1.000 250.03536 ? 404 SER F N   1 
ATOM 2771 C CA  . SER A 1 404 ? -55.77300 -16.70500 -26.49700 1.000 238.26823 ? 404 SER F CA  1 
ATOM 2772 C C   . SER A 1 404 ? -54.60600 -15.75800 -26.74300 1.000 235.79667 ? 404 SER F C   1 
ATOM 2773 O O   . SER A 1 404 ? -53.44500 -16.11000 -26.49000 1.000 234.47927 ? 404 SER F O   1 
ATOM 2774 C CB  . SER A 1 404 ? -56.29800 -16.49800 -25.07200 1.000 233.72925 ? 404 SER F CB  1 
ATOM 2775 O OG  . SER A 1 404 ? -55.34000 -16.83500 -24.09400 1.000 240.45968 ? 404 SER F OG  1 
ATOM 2776 N N   . TYR A 1 405 ? -54.89600 -14.56300 -27.22700 1.000 236.29901 ? 405 TYR F N   1 
ATOM 2777 C CA  . TYR A 1 405 ? -53.87000 -13.53600 -27.35400 1.000 239.69562 ? 405 TYR F CA  1 
ATOM 2778 C C   . TYR A 1 405 ? -54.12700 -12.43900 -26.32300 1.000 239.63094 ? 405 TYR F C   1 
ATOM 2779 O O   . TYR A 1 405 ? -55.22800 -11.88400 -26.27500 1.000 238.35765 ? 405 TYR F O   1 
ATOM 2780 C CB  . TYR A 1 405 ? -53.78300 -12.94400 -28.75200 1.000 244.29768 ? 405 TYR F CB  1 
ATOM 2781 C CG  . TYR A 1 405 ? -52.73300 -11.84200 -28.76600 1.000 245.58813 ? 405 TYR F CG  1 
ATOM 2782 C CD1 . TYR A 1 405 ? -51.38100 -12.12400 -28.53600 1.000 241.73399 ? 405 TYR F CD1 1 
ATOM 2783 C CD2 . TYR A 1 405 ? -53.10100 -10.50400 -28.93500 1.000 249.46733 ? 405 TYR F CD2 1 
ATOM 2784 C CE1 . TYR A 1 405 ? -50.42100 -11.08900 -28.51600 1.000 245.26637 ? 405 TYR F CE1 1 
ATOM 2785 C CE2 . TYR A 1 405 ? -52.15100 -9.47300  -28.92000 1.000 245.83702 ? 405 TYR F CE2 1 
ATOM 2786 C CZ  . TYR A 1 405 ? -50.81900 -9.76600  -28.70900 1.000 245.85267 ? 405 TYR F CZ  1 
ATOM 2787 O OH  . TYR A 1 405 ? -49.89600 -8.73600  -28.69500 1.000 238.53161 ? 405 TYR F OH  1 
ATOM 2788 N N   . ILE A 1 406 ? -53.15600 -12.18500 -25.44700 1.000 237.48705 ? 406 ILE F N   1 
ATOM 2789 C CA  . ILE A 1 406 ? -53.28400 -11.14800 -24.42600 1.000 231.41051 ? 406 ILE F CA  1 
ATOM 2790 C C   . ILE A 1 406 ? -52.32800 -9.98700  -24.71600 1.000 232.79868 ? 406 ILE F C   1 
ATOM 2791 O O   . ILE A 1 406 ? -51.14200 -10.21600 -24.96900 1.000 234.08367 ? 406 ILE F O   1 
ATOM 2792 C CB  . ILE A 1 406 ? -53.05200 -11.74600 -23.04000 1.000 227.59737 ? 406 ILE F CB  1 
ATOM 2793 C CG1 . ILE A 1 406 ? -53.94400 -12.98600 -22.91000 1.000 228.53376 ? 406 ILE F CG1 1 
ATOM 2794 C CG2 . ILE A 1 406 ? -53.38800 -10.72200 -21.99800 1.000 226.25436 ? 406 ILE F CG2 1 
ATOM 2795 C CD1 . ILE A 1 406 ? -55.41000 -12.76100 -23.13000 1.000 230.45420 ? 406 ILE F CD1 1 
ATOM 2796 N N   . THR A 1 407 ? -52.83000 -8.75000  -24.67300 1.000 231.96814 ? 407 THR F N   1 
ATOM 2797 C CA  . THR A 1 407 ? -52.03300 -7.52400  -24.83900 1.000 237.23966 ? 407 THR F CA  1 
ATOM 2798 C C   . THR A 1 407 ? -51.38300 -7.04800  -23.54100 1.000 242.23389 ? 407 THR F C   1 
ATOM 2799 O O   . THR A 1 407 ? -51.92500 -7.23800  -22.45500 1.000 244.10380 ? 407 THR F O   1 
ATOM 2800 C CB  . THR A 1 407 ? -52.87500 -6.39900  -25.43900 1.000 238.69499 ? 407 THR F CB  1 
ATOM 2801 O OG1 . THR A 1 407 ? -53.27800 -6.79800  -26.74700 1.000 248.64451 ? 407 THR F OG1 1 
ATOM 2802 C CG2 . THR A 1 407 ? -52.13500 -5.04600  -25.49700 1.000 237.52692 ? 407 THR F CG2 1 
ATOM 2803 N N   . ASN A 1 408 ? -50.17500 -6.46600  -23.66500 1.000 248.14573 ? 408 ASN F N   1 
ATOM 2804 C CA  . ASN A 1 408 ? -49.46600 -5.88000  -22.52200 1.000 250.32174 ? 408 ASN F CA  1 
ATOM 2805 C C   . ASN A 1 408 ? -50.07800 -4.57900  -21.99900 1.000 243.36392 ? 408 ASN F C   1 
ATOM 2806 O O   . ASN A 1 408 ? -49.62700 -4.05600  -20.96800 1.000 237.19109 ? 408 ASN F O   1 
ATOM 2807 C CB  . ASN A 1 408 ? -48.01800 -5.58800  -22.93300 1.000 254.96072 ? 408 ASN F CB  1 
ATOM 2808 C CG  . ASN A 1 408 ? -47.91900 -4.63800  -24.15800 1.000 257.11119 ? 408 ASN F CG  1 
ATOM 2809 O OD1 . ASN A 1 408 ? -48.91700 -4.04000  -24.59500 1.000 254.96969 ? 408 ASN F OD1 1 
ATOM 2810 N ND2 . ASN A 1 408 ? -46.69400 -4.46400  -24.67500 1.000 255.77638 ? 408 ASN F ND2 1 
ATOM 2811 N N   . GLN A 1 409 ? -51.08200 -4.04600  -22.66700 1.000 236.10932 ? 409 GLN F N   1 
ATOM 2812 C CA  . GLN A 1 409 ? -51.92400 -3.04800  -22.04800 1.000 236.84795 ? 409 GLN F CA  1 
ATOM 2813 C C   . GLN A 1 409 ? -53.01900 -3.71500  -21.22900 1.000 250.90588 ? 409 GLN F C   1 
ATOM 2814 O O   . GLN A 1 409 ? -53.40400 -3.19200  -20.17100 1.000 260.59937 ? 409 GLN F O   1 
ATOM 2815 C CB  . GLN A 1 409 ? -52.50600 -2.07600  -23.06900 1.000 239.32990 ? 409 GLN F CB  1 
ATOM 2816 C CG  . GLN A 1 409 ? -51.52300 -1.49000  -24.02400 1.000 242.46136 ? 409 GLN F CG  1 
ATOM 2817 C CD  . GLN A 1 409 ? -50.62600 -0.50300  -23.30300 1.000 260.43478 ? 409 GLN F CD  1 
ATOM 2818 O OE1 . GLN A 1 409 ? -49.41900 -0.63700  -23.34400 1.000 266.29378 ? 409 GLN F OE1 1 
ATOM 2819 N NE2 . GLN A 1 409 ? -51.21600 0.44600   -22.57500 1.000 264.31193 ? 409 GLN F NE2 1 
ATOM 2820 N N   . ASP A 1 410 ? -53.39300 -4.95200  -21.63600 1.000 250.92723 ? 410 ASP F N   1 
ATOM 2821 C CA  . ASP A 1 410 ? -54.45200 -5.76200  -21.00500 1.000 256.77093 ? 410 ASP F CA  1 
ATOM 2822 C C   . ASP A 1 410 ? -54.06500 -6.29000  -19.61600 1.000 251.98394 ? 410 ASP F C   1 
ATOM 2823 O O   . ASP A 1 410 ? -54.93100 -6.42400  -18.73100 1.000 241.90564 ? 410 ASP F O   1 
ATOM 2824 C CB  . ASP A 1 410 ? -54.77500 -6.94900  -21.92900 1.000 249.66778 ? 410 ASP F CB  1 
ATOM 2825 C CG  . ASP A 1 410 ? -55.33500 -6.53700  -23.29700 1.000 248.26361 ? 410 ASP F CG  1 
ATOM 2826 O OD1 . ASP A 1 410 ? -55.48600 -5.33200  -23.59500 1.000 254.43526 ? 410 ASP F OD1 1 
ATOM 2827 O OD2 . ASP A 1 410 ? -55.57100 -7.46300  -24.10200 1.000 244.21106 ? 410 ASP F OD2 1 
ATOM 2828 N N   . ALA A 1 411 ? -52.81800 -6.71400  -19.43500 1.000 251.83720 ? 411 ALA F N   1 
ATOM 2829 C CA  . ALA A 1 411 ? -52.44000 -7.37900  -18.20400 1.000 243.40364 ? 411 ALA F CA  1 
ATOM 2830 C C   . ALA A 1 411 ? -51.02800 -6.90500  -17.90100 1.000 237.86164 ? 411 ALA F C   1 
ATOM 2831 O O   . ALA A 1 411 ? -50.27900 -6.46500  -18.78000 1.000 235.38951 ? 411 ALA F O   1 
ATOM 2832 C CB  . ALA A 1 411 ? -52.51600 -8.92100  -18.29000 1.000 227.23755 ? 411 ALA F CB  1 
ATOM 2833 N N   . ASP A 1 412 ? -50.65600 -7.05600  -16.65400 1.000 231.43985 ? 412 ASP F N   1 
ATOM 2834 C CA  . ASP A 1 412 ? -49.29300 -6.83300  -16.24500 1.000 221.99154 ? 412 ASP F CA  1 
ATOM 2835 C C   . ASP A 1 412 ? -48.56000 -8.15000  -16.10200 1.000 213.43728 ? 412 ASP F C   1 
ATOM 2836 O O   . ASP A 1 412 ? -47.33200 -8.17300  -16.20700 1.000 214.45692 ? 412 ASP F O   1 
ATOM 2837 C CB  . ASP A 1 412 ? -49.30200 -5.96600  -14.96900 1.000 232.63959 ? 412 ASP F CB  1 
ATOM 2838 C CG  . ASP A 1 412 ? -49.85400 -4.49200  -15.22500 1.000 237.11139 ? 412 ASP F CG  1 
ATOM 2839 O OD1 . ASP A 1 412 ? -50.70700 -4.26700  -16.11700 1.000 235.51371 ? 412 ASP F OD1 1 
ATOM 2840 O OD2 . ASP A 1 412 ? -49.50300 -3.55100  -14.47300 1.000 238.91193 ? 412 ASP F OD2 1 
ATOM 2841 N N   . THR A 1 413 ? -49.28400 -9.20300  -15.72000 1.000 207.32324 ? 413 THR F N   1 
ATOM 2842 C CA  . THR A 1 413 ? -48.73600 -10.54300 -15.57700 1.000 212.19869 ? 413 THR F CA  1 
ATOM 2843 C C   . THR A 1 413 ? -49.66000 -11.62400 -16.16300 1.000 213.26882 ? 413 THR F C   1 
ATOM 2844 O O   . THR A 1 413 ? -50.84600 -11.36200 -16.36100 1.000 209.35323 ? 413 THR F O   1 
ATOM 2845 C CB  . THR A 1 413 ? -48.45000 -10.75100 -14.07800 1.000 212.19831 ? 413 THR F CB  1 
ATOM 2846 O OG1 . THR A 1 413 ? -47.93400 -12.06200 -13.83300 1.000 220.14619 ? 413 THR F OG1 1 
ATOM 2847 C CG2 . THR A 1 413 ? -49.65200 -10.42500 -13.21300 1.000 210.59706 ? 413 THR F CG2 1 
ATOM 2848 N N   . VAL A 1 414 ? -49.07200 -12.78000 -16.59900 1.000 219.53878 ? 414 VAL F N   1 
ATOM 2849 C CA  . VAL A 1 414 ? -49.77700 -14.04600 -16.91800 1.000 222.88674 ? 414 VAL F CA  1 
ATOM 2850 C C   . VAL A 1 414 ? -49.14400 -15.22300 -16.16600 1.000 219.23682 ? 414 VAL F C   1 
ATOM 2851 O O   . VAL A 1 414 ? -47.91600 -15.34100 -16.11100 1.000 211.51598 ? 414 VAL F O   1 
ATOM 2852 C CB  . VAL A 1 414 ? -49.81000 -14.40600 -18.41900 1.000 221.55632 ? 414 VAL F CB  1 
ATOM 2853 C CG1 . VAL A 1 414 ? -50.36000 -15.85800 -18.63900 1.000 208.24275 ? 414 VAL F CG1 1 
ATOM 2854 C CG2 . VAL A 1 414 ? -50.67700 -13.44200 -19.13000 1.000 225.71691 ? 414 VAL F CG2 1 
ATOM 2855 N N   . THR A 1 415 ? -49.96900 -16.14500 -15.66200 1.000 224.46445 ? 415 THR F N   1 
ATOM 2856 C CA  . THR A 1 415 ? -49.45700 -17.29400 -14.92900 1.000 215.59884 ? 415 THR F CA  1 
ATOM 2857 C C   . THR A 1 415 ? -50.03200 -18.54400 -15.54500 1.000 215.57927 ? 415 THR F C   1 
ATOM 2858 O O   . THR A 1 415 ? -51.16400 -18.54200 -16.01300 1.000 217.77296 ? 415 THR F O   1 
ATOM 2859 C CB  . THR A 1 415 ? -49.84700 -17.27600 -13.43700 1.000 212.23706 ? 415 THR F CB  1 
ATOM 2860 O OG1 . THR A 1 415 ? -49.41900 -16.06200 -12.81900 1.000 206.41234 ? 415 THR F OG1 1 
ATOM 2861 C CG2 . THR A 1 415 ? -49.21900 -18.41900 -12.72100 1.000 214.55470 ? 415 THR F CG2 1 
ATOM 2862 N N   . ILE A 1 416 ? -49.20400 -19.54600 -15.71700 1.000 215.06659 ? 416 ILE F N   1 
ATOM 2863 C CA  . ILE A 1 416 ? -49.64100 -20.91900 -15.91100 1.000 222.20308 ? 416 ILE F CA  1 
ATOM 2864 C C   . ILE A 1 416 ? -49.28400 -21.80500 -14.71300 1.000 226.52882 ? 416 ILE F C   1 
ATOM 2865 O O   . ILE A 1 416 ? -48.10500 -22.12800 -14.52500 1.000 224.58628 ? 416 ILE F O   1 
ATOM 2866 C CB  . ILE A 1 416 ? -49.10600 -21.42700 -17.22800 1.000 226.59799 ? 416 ILE F CB  1 
ATOM 2867 C CG1 . ILE A 1 416 ? -49.49100 -20.31100 -18.21100 1.000 222.08404 ? 416 ILE F CG1 1 
ATOM 2868 C CG2 . ILE A 1 416 ? -49.66700 -22.79500 -17.50100 1.000 236.13470 ? 416 ILE F CG2 1 
ATOM 2869 C CD1 . ILE A 1 416 ? -49.52000 -20.71900 -19.57100 1.000 232.37079 ? 416 ILE F CD1 1 
ATOM 2870 N N   . ASP A 1 417 ? -50.28200 -22.29400 -13.96500 1.000 234.16102 ? 417 ASP F N   1 
ATOM 2871 C CA  . ASP A 1 417 ? -50.03700 -22.95200 -12.66800 1.000 236.19539 ? 417 ASP F CA  1 
ATOM 2872 C C   . ASP A 1 417 ? -49.18400 -22.11600 -11.73000 1.000 238.94055 ? 417 ASP F C   1 
ATOM 2873 O O   . ASP A 1 417 ? -49.60400 -21.04400 -11.28300 1.000 240.03129 ? 417 ASP F O   1 
ATOM 2874 C CB  . ASP A 1 417 ? -49.39700 -24.34700 -12.74100 1.000 233.20832 ? 417 ASP F CB  1 
ATOM 2875 C CG  . ASP A 1 417 ? -50.36000 -25.41200 -13.13000 1.000 234.31889 ? 417 ASP F CG  1 
ATOM 2876 O OD1 . ASP A 1 417 ? -51.54900 -25.10700 -13.25600 1.000 235.78046 ? 417 ASP F OD1 1 
ATOM 2877 O OD2 . ASP A 1 417 ? -49.96000 -26.58100 -13.17600 1.000 236.34496 ? 417 ASP F OD2 1 
ATOM 2878 N N   . ASN A 1 418 ? -47.99700 -22.62800 -11.39600 1.000 241.92646 ? 418 ASN F N   1 
ATOM 2879 C CA  . ASN A 1 418 ? -47.05300 -21.92800 -10.53800 1.000 244.89663 ? 418 ASN F CA  1 
ATOM 2880 C C   . ASN A 1 418 ? -45.95200 -21.21500 -11.32600 1.000 245.42611 ? 418 ASN F C   1 
ATOM 2881 O O   . ASN A 1 418 ? -45.13900 -20.48700 -10.73300 1.000 246.47653 ? 418 ASN F O   1 
ATOM 2882 C CB  . ASN A 1 418 ? -46.50300 -22.94300 -9.52400  1.000 243.70251 ? 418 ASN F CB  1 
ATOM 2883 C CG  . ASN A 1 418 ? -46.02500 -24.21400 -10.20000 1.000 251.40905 ? 418 ASN F CG  1 
ATOM 2884 O OD1 . ASN A 1 418 ? -46.65800 -24.68700 -11.15400 1.000 248.38112 ? 418 ASN F OD1 1 
ATOM 2885 N ND2 . ASN A 1 418 ? -44.92600 -24.77500 -9.72300  1.000 256.50926 ? 418 ASN F ND2 1 
ATOM 2886 N N   . THR A 1 419 ? -45.88200 -21.43800 -12.63900 1.000 239.46721 ? 419 THR F N   1 
ATOM 2887 C CA  . THR A 1 419 ? -44.89100 -20.77500 -13.46600 1.000 235.32019 ? 419 THR F CA  1 
ATOM 2888 C C   . THR A 1 419 ? -45.40300 -19.35000 -13.67100 1.000 230.69554 ? 419 THR F C   1 
ATOM 2889 O O   . THR A 1 419 ? -46.50700 -19.16600 -14.20400 1.000 228.66590 ? 419 THR F O   1 
ATOM 2890 C CB  . THR A 1 419 ? -44.72300 -21.53200 -14.78900 1.000 234.49394 ? 419 THR F CB  1 
ATOM 2891 O OG1 . THR A 1 419 ? -45.76000 -21.14600 -15.70600 1.000 238.10648 ? 419 THR F OG1 1 
ATOM 2892 C CG2 . THR A 1 419 ? -44.78200 -23.04900 -14.57500 1.000 225.34471 ? 419 THR F CG2 1 
ATOM 2893 N N   . VAL A 1 420 ? -44.66700 -18.34500 -13.21700 1.000 222.75247 ? 420 VAL F N   1 
ATOM 2894 C CA  . VAL A 1 420 ? -45.12900 -16.96500 -13.35000 1.000 215.92457 ? 420 VAL F CA  1 
ATOM 2895 C C   . VAL A 1 420 ? -44.50800 -16.36000 -14.61400 1.000 222.69967 ? 420 VAL F C   1 
ATOM 2896 O O   . VAL A 1 420 ? -43.29300 -16.46900 -14.80700 1.000 235.19102 ? 420 VAL F O   1 
ATOM 2897 C CB  . VAL A 1 420 ? -44.80600 -16.18300 -12.06500 1.000 204.08274 ? 420 VAL F CB  1 
ATOM 2898 C CG1 . VAL A 1 420 ? -43.31400 -16.27300 -11.73200 1.000 190.18464 ? 420 VAL F CG1 1 
ATOM 2899 C CG2 . VAL A 1 420 ? -45.27600 -14.76600 -12.17400 1.000 209.52571 ? 420 VAL F CG2 1 
ATOM 2900 N N   . TYR A 1 421 ? -45.31100 -15.68800 -15.46600 1.000 213.98957 ? 421 TYR F N   1 
ATOM 2901 C CA  . TYR A 1 421 ? -44.78400 -14.92900 -16.61200 1.000 209.54816 ? 421 TYR F CA  1 
ATOM 2902 C C   . TYR A 1 421 ? -45.18900 -13.48900 -16.49700 1.000 211.07452 ? 421 TYR F C   1 
ATOM 2903 O O   . TYR A 1 421 ? -46.30800 -13.15500 -16.88200 1.000 213.76119 ? 421 TYR F O   1 
ATOM 2904 C CB  . TYR A 1 421 ? -45.31700 -15.39700 -17.95000 1.000 209.83237 ? 421 TYR F CB  1 
ATOM 2905 C CG  . TYR A 1 421 ? -45.01200 -16.78900 -18.33300 1.000 219.20188 ? 421 TYR F CG  1 
ATOM 2906 C CD1 . TYR A 1 421 ? -43.79200 -17.12800 -18.90000 1.000 216.66698 ? 421 TYR F CD1 1 
ATOM 2907 C CD2 . TYR A 1 421 ? -45.98500 -17.76900 -18.19000 1.000 225.31961 ? 421 TYR F CD2 1 
ATOM 2908 C CE1 . TYR A 1 421 ? -43.52900 -18.44600 -19.26500 1.000 220.41406 ? 421 TYR F CE1 1 
ATOM 2909 C CE2 . TYR A 1 421 ? -45.75000 -19.06700 -18.55100 1.000 233.29904 ? 421 TYR F CE2 1 
ATOM 2910 C CZ  . TYR A 1 421 ? -44.51200 -19.41000 -19.09100 1.000 230.49857 ? 421 TYR F CZ  1 
ATOM 2911 O OH  . TYR A 1 421 ? -44.27100 -20.72000 -19.44800 1.000 227.75572 ? 421 TYR F OH  1 
ATOM 2912 N N   . CYS A 1 422 ? -44.33500 -12.59200 -16.08600 1.000 217.86697 ? 422 CYS F N   1 
ATOM 2913 C CA  . CYS A 1 422 ? -44.91600 -11.26200 -16.14600 1.000 227.36028 ? 422 CYS F CA  1 
ATOM 2914 C C   . CYS A 1 422 ? -44.72600 -10.67200 -17.54300 1.000 228.86205 ? 422 CYS F C   1 
ATOM 2915 O O   . CYS A 1 422 ? -44.17400 -11.31400 -18.44500 1.000 219.94051 ? 422 CYS F O   1 
ATOM 2916 C CB  . CYS A 1 422 ? -44.33800 -10.37700 -15.05700 1.000 228.58315 ? 422 CYS F CB  1 
ATOM 2917 S SG  . CYS A 1 422 ? -42.66400 -10.65800 -15.01800 1.000 233.44325 ? 422 CYS F SG  1 
ATOM 2918 N N   . LEU A 1 423 ? -45.21700 -9.43200  -17.71000 1.000 233.17850 ? 423 LEU F N   1 
ATOM 2919 C CA  . LEU A 1 423 ? -45.25600 -8.71500  -18.98800 1.000 220.53390 ? 423 LEU F CA  1 
ATOM 2920 C C   . LEU A 1 423 ? -44.83600 -7.25600  -18.84000 1.000 219.53770 ? 423 LEU F C   1 
ATOM 2921 O O   . LEU A 1 423 ? -44.98700 -6.63900  -17.78100 1.000 226.06456 ? 423 LEU F O   1 
ATOM 2922 C CB  . LEU A 1 423 ? -46.65400 -8.71900  -19.61500 1.000 211.30604 ? 423 LEU F CB  1 
ATOM 2923 C CG  . LEU A 1 423 ? -47.08900 -9.88500  -20.48100 1.000 205.12844 ? 423 LEU F CG  1 
ATOM 2924 C CD1 . LEU A 1 423 ? -48.44200 -9.56400  -21.03800 1.000 213.68527 ? 423 LEU F CD1 1 
ATOM 2925 C CD2 . LEU A 1 423 ? -46.09600 -10.03900 -21.60700 1.000 198.29679 ? 423 LEU F CD2 1 
ATOM 2926 N N   . SER A 1 424 ? -44.36000 -6.70500  -19.96100 1.000 215.49048 ? 424 SER F N   1 
ATOM 2927 C CA  . SER A 1 424 ? -44.01000 -5.29900  -20.14400 1.000 222.12231 ? 424 SER F CA  1 
ATOM 2928 C C   . SER A 1 424 ? -45.24500 -4.41300  -20.27800 1.000 230.82854 ? 424 SER F C   1 
ATOM 2929 O O   . SER A 1 424 ? -46.37400 -4.89400  -20.39500 1.000 229.35532 ? 424 SER F O   1 
ATOM 2930 C CB  . SER A 1 424 ? -43.16200 -5.11600  -21.39100 1.000 232.70545 ? 424 SER F CB  1 
ATOM 2931 O OG  . SER A 1 424 ? -43.89100 -5.55500  -22.51700 1.000 232.87919 ? 424 SER F OG  1 
ATOM 2932 N N   . LYS A 1 425 ? -45.02100 -3.09900  -20.13600 1.000 234.83392 ? 425 LYS F N   1 
ATOM 2933 C CA  . LYS A 1 425 ? -46.01800 -2.04800  -20.36100 1.000 239.54845 ? 425 LYS F CA  1 
ATOM 2934 C C   . LYS A 1 425 ? -45.70000 -1.17100  -21.58100 1.000 247.88986 ? 425 LYS F C   1 
ATOM 2935 O O   . LYS A 1 425 ? -46.02300 0.01400   -21.56500 1.000 257.33173 ? 425 LYS F O   1 
ATOM 2936 C CB  . LYS A 1 425 ? -46.20300 -1.14700  -19.12700 1.000 237.35290 ? 425 LYS F CB  1 
ATOM 2937 C CG  . LYS A 1 425 ? -47.66800 -0.56000  -18.78500 1.000 236.54349 ? 425 LYS F CG  1 
ATOM 2938 C CD  . LYS A 1 425 ? -48.82800 -1.51800  -18.33500 1.000 222.15768 ? 425 LYS F CD  1 
ATOM 2939 C CE  . LYS A 1 425 ? -50.15900 -0.73900  -18.11900 1.000 204.17966 ? 425 LYS F CE  1 
ATOM 2940 N NZ  . LYS A 1 425 ? -51.30600 -1.59000  -17.68700 1.000 193.23713 ? 425 LYS F NZ  1 
ATOM 2941 N N   . VAL A 1 426 ? -44.91900 -1.65500  -22.54600 1.000 254.12963 ? 426 VAL F N   1 
ATOM 2942 C CA  . VAL A 1 426 ? -44.63300 -0.89600  -23.77000 1.000 264.36179 ? 426 VAL F CA  1 
ATOM 2943 C C   . VAL A 1 426 ? -45.85600 -0.65300  -24.68200 1.000 271.18269 ? 426 VAL F C   1 
ATOM 2944 O O   . VAL A 1 426 ? -46.63600 -1.57700  -24.96600 1.000 268.29564 ? 426 VAL F O   1 
ATOM 2945 C CB  . VAL A 1 426 ? -43.52000 -1.64800  -24.49800 1.000 268.39811 ? 426 VAL F CB  1 
ATOM 2946 C CG1 . VAL A 1 426 ? -43.02000 -0.83000  -25.65200 1.000 278.67564 ? 426 VAL F CG1 1 
ATOM 2947 C CG2 . VAL A 1 426 ? -42.43700 -1.96400  -23.49200 1.000 265.73858 ? 426 VAL F CG2 1 
ATOM 2948 N N   . GLU A 1 427 ? -45.95400 0.58100   -25.25300 1.000 286.08360 ? 427 GLU F N   1 
ATOM 2949 C CA  . GLU A 1 427 ? -47.03200 1.12300   -26.11600 1.000 286.10939 ? 427 GLU F CA  1 
ATOM 2950 C C   . GLU A 1 427 ? -46.74700 1.09300   -27.61900 1.000 283.07082 ? 427 GLU F C   1 
ATOM 2951 O O   . GLU A 1 427 ? -45.63000 1.33900   -28.07900 1.000 294.50684 ? 427 GLU F O   1 
ATOM 2952 C CB  . GLU A 1 427 ? -47.44800 2.56900   -25.78100 1.000 288.88771 ? 427 GLU F CB  1 
ATOM 2953 C CG  . GLU A 1 427 ? -48.15900 2.74600   -24.45900 1.000 296.61396 ? 427 GLU F CG  1 
ATOM 2954 C CD  . GLU A 1 427 ? -47.21800 2.69100   -23.27400 1.000 312.11813 ? 427 GLU F CD  1 
ATOM 2955 O OE1 . GLU A 1 427 ? -45.99400 2.47200   -23.47800 1.000 315.11982 ? 427 GLU F OE1 1 
ATOM 2956 O OE2 . GLU A 1 427 ? -47.72100 2.82100   -22.12900 1.000 323.72748 ? 427 GLU F OE2 1 
ATOM 2957 N N   . GLY A 1 428 ? -47.80500 0.88700   -28.37800 1.000 271.93936 ? 428 GLY F N   1 
ATOM 2958 C CA  . GLY A 1 428 ? -47.75000 0.78500   -29.82100 1.000 268.33387 ? 428 GLY F CA  1 
ATOM 2959 C C   . GLY A 1 428 ? -49.05600 0.19100   -30.27300 1.000 272.01646 ? 428 GLY F C   1 
ATOM 2960 O O   . GLY A 1 428 ? -49.86500 -0.25000  -29.46100 1.000 277.04841 ? 428 GLY F O   1 
ATOM 2961 N N   . GLU A 1 429 ? -49.30300 0.24000   -31.58100 1.000 272.01747 ? 429 GLU F N   1 
ATOM 2962 C CA  . GLU A 1 429 ? -50.60500 -0.22100  -32.04300 1.000 279.90272 ? 429 GLU F CA  1 
ATOM 2963 C C   . GLU A 1 429 ? -50.57300 -1.72600  -32.39200 1.000 270.20754 ? 429 GLU F C   1 
ATOM 2964 O O   . GLU A 1 429 ? -49.73100 -2.17800  -33.18700 1.000 253.82330 ? 429 GLU F O   1 
ATOM 2965 C CB  . GLU A 1 429 ? -51.01500 0.65200   -33.24700 1.000 279.28047 ? 429 GLU F CB  1 
ATOM 2966 C CG  . GLU A 1 429 ? -52.52400 0.88100   -33.46700 1.000 288.30260 ? 429 GLU F CG  1 
ATOM 2967 C CD  . GLU A 1 429 ? -53.18200 1.61400   -32.28700 1.000 279.13605 ? 429 GLU F CD  1 
ATOM 2968 O OE1 . GLU A 1 429 ? -52.66800 2.68300   -31.91000 1.000 271.66459 ? 429 GLU F OE1 1 
ATOM 2969 O OE2 . GLU A 1 429 ? -54.19000 1.11900   -31.71400 1.000 266.81435 ? 429 GLU F OE2 1 
ATOM 2970 N N   . GLN A 1 430 ? -51.55100 -2.47900  -31.83300 1.000 274.73156 ? 430 GLN F N   1 
ATOM 2971 C CA  . GLN A 1 430 ? -51.85700 -3.90100  -32.04900 1.000 263.89430 ? 430 GLN F CA  1 
ATOM 2972 C C   . GLN A 1 430 ? -53.07500 -4.11600  -32.97600 1.000 268.34943 ? 430 GLN F C   1 
ATOM 2973 O O   . GLN A 1 430 ? -54.02800 -3.32900  -32.95000 1.000 271.14212 ? 430 GLN F O   1 
ATOM 2974 C CB  . GLN A 1 430 ? -52.05400 -4.56800  -30.66900 1.000 259.76804 ? 430 GLN F CB  1 
ATOM 2975 C CG  . GLN A 1 430 ? -52.90700 -3.73400  -29.62800 1.000 267.08573 ? 430 GLN F CG  1 
ATOM 2976 C CD  . GLN A 1 430 ? -52.08300 -2.86800  -28.61000 1.000 269.16913 ? 430 GLN F CD  1 
ATOM 2977 O OE1 . GLN A 1 430 ? -50.98200 -2.40300  -28.91100 1.000 272.98009 ? 430 GLN F OE1 1 
ATOM 2978 N NE2 . GLN A 1 430 ? -52.66100 -2.61900  -27.42600 1.000 266.58488 ? 430 GLN F NE2 1 
ATOM 2979 N N   . HIS A 1 431 ? -53.07300 -5.21000  -33.76800 1.000 264.74293 ? 431 HIS F N   1 
ATOM 2980 C CA  . HIS A 1 431 ? -54.20300 -5.50900  -34.66800 1.000 262.42347 ? 431 HIS F CA  1 
ATOM 2981 C C   . HIS A 1 431 ? -54.50900 -7.00500  -34.84100 1.000 255.86025 ? 431 HIS F C   1 
ATOM 2982 O O   . HIS A 1 431 ? -53.60100 -7.80700  -35.02800 1.000 252.97350 ? 431 HIS F O   1 
ATOM 2983 C CB  . HIS A 1 431 ? -53.91300 -4.83300  -36.01200 1.000 269.10374 ? 431 HIS F CB  1 
ATOM 2984 C CG  . HIS A 1 431 ? -53.53100 -3.38400  -35.88000 1.000 286.05750 ? 431 HIS F CG  1 
ATOM 2985 N ND1 . HIS A 1 431 ? -52.22500 -2.96400  -35.73900 1.000 290.62240 ? 431 HIS F ND1 1 
ATOM 2986 C CD2 . HIS A 1 431 ? -54.27800 -2.25400  -35.91800 1.000 290.00199 ? 431 HIS F CD2 1 
ATOM 2987 C CE1 . HIS A 1 431 ? -52.18900 -1.64400  -35.64800 1.000 292.08724 ? 431 HIS F CE1 1 
ATOM 2988 N NE2 . HIS A 1 431 ? -53.42100 -1.18600  -35.76600 1.000 293.48317 ? 431 HIS F NE2 1 
ATOM 2989 N N   . VAL A 1 432 ? -55.79700 -7.36600  -34.85100 1.000 255.55413 ? 432 VAL F N   1 
ATOM 2990 C CA  . VAL A 1 432 ? -56.26100 -8.75300  -35.06500 1.000 258.70817 ? 432 VAL F CA  1 
ATOM 2991 C C   . VAL A 1 432 ? -56.72900 -8.99100  -36.50700 1.000 267.94220 ? 432 VAL F C   1 
ATOM 2992 O O   . VAL A 1 432 ? -57.56200 -8.23400  -37.01700 1.000 278.64501 ? 432 VAL F O   1 
ATOM 2993 C CB  . VAL A 1 432 ? -57.38900 -9.12100  -34.08600 1.000 253.64783 ? 432 VAL F CB  1 
ATOM 2994 C CG1 . VAL A 1 432 ? -57.98900 -10.45000 -34.47100 1.000 256.96627 ? 432 VAL F CG1 1 
ATOM 2995 C CG2 . VAL A 1 432 ? -56.88000 -9.14600  -32.66300 1.000 253.83643 ? 432 VAL F CG2 1 
ATOM 2996 N N   . ILE A 1 433 ? -56.14400 -9.98200  -37.20000 1.000 267.27918 ? 433 ILE F N   1 
ATOM 2997 C CA  . ILE A 1 433 ? -56.57300 -10.39100 -38.55100 1.000 271.55269 ? 433 ILE F CA  1 
ATOM 2998 C C   . ILE A 1 433 ? -57.49300 -11.61300 -38.45800 1.000 267.76287 ? 433 ILE F C   1 
ATOM 2999 O O   . ILE A 1 433 ? -57.01600 -12.74800 -38.33900 1.000 260.96631 ? 433 ILE F O   1 
ATOM 3000 C CB  . ILE A 1 433 ? -55.38600 -10.68300 -39.47200 1.000 268.17041 ? 433 ILE F CB  1 
ATOM 3001 C CG1 . ILE A 1 433 ? -54.60100 -9.38500  -39.72600 1.000 269.35594 ? 433 ILE F CG1 1 
ATOM 3002 C CG2 . ILE A 1 433 ? -55.83800 -11.45200 -40.75900 1.000 264.87308 ? 433 ILE F CG2 1 
ATOM 3003 C CD1 . ILE A 1 433 ? -55.37900 -8.27400  -40.45800 1.000 271.91440 ? 433 ILE F CD1 1 
ATOM 3004 N N   . LYS A 1 434 ? -58.82400 -11.40700 -38.55900 1.000 274.74353 ? 434 LYS F N   1 
ATOM 3005 C CA  . LYS A 1 434 ? -59.73100 -12.51900 -38.28700 1.000 271.92875 ? 434 LYS F CA  1 
ATOM 3006 C C   . LYS A 1 434 ? -59.53800 -13.62800 -39.31800 1.000 266.92707 ? 434 LYS F C   1 
ATOM 3007 O O   . LYS A 1 434 ? -59.16500 -13.40000 -40.47700 1.000 255.68626 ? 434 LYS F O   1 
ATOM 3008 C CB  . LYS A 1 434 ? -61.21600 -12.03800 -38.17800 1.000 278.27691 ? 434 LYS F CB  1 
ATOM 3009 C CG  . LYS A 1 434 ? -61.70300 -10.69700 -38.90500 1.000 283.73150 ? 434 LYS F CG  1 
ATOM 3010 C CD  . LYS A 1 434 ? -63.24700 -10.39400 -38.70600 1.000 280.66165 ? 434 LYS F CD  1 
ATOM 3011 C CE  . LYS A 1 434 ? -63.80500 -9.11500  -39.42600 1.000 263.38958 ? 434 LYS F CE  1 
ATOM 3012 N NZ  . LYS A 1 434 ? -63.67800 -8.98700  -40.91100 1.000 257.84880 ? 434 LYS F NZ  1 
ATOM 3013 N N   . GLY A 1 435 ? -59.72500 -14.85000 -38.83700 1.000 271.18495 ? 435 GLY F N   1 
ATOM 3014 C CA  . GLY A 1 435 ? -59.64100 -16.05400 -39.62600 1.000 282.62947 ? 435 GLY F CA  1 
ATOM 3015 C C   . GLY A 1 435 ? -59.74900 -17.26900 -38.71900 1.000 291.92791 ? 435 GLY F C   1 
ATOM 3016 O O   . GLY A 1 435 ? -59.29500 -17.18700 -37.57600 1.000 290.13489 ? 435 GLY F O   1 
ATOM 3017 N N   . ARG A 1 436 ? -60.36500 -18.35700 -39.14900 1.000 300.47189 ? 436 ARG F N   1 
ATOM 3018 C CA  . ARG A 1 436 ? -60.36900 -19.59700 -38.36100 1.000 302.47804 ? 436 ARG F CA  1 
ATOM 3019 C C   . ARG A 1 436 ? -58.94100 -20.13700 -38.16100 1.000 294.58876 ? 436 ARG F C   1 
ATOM 3020 O O   . ARG A 1 436 ? -58.18100 -20.20600 -39.13400 1.000 296.34844 ? 436 ARG F O   1 
ATOM 3021 C CB  . ARG A 1 436 ? -61.18200 -20.63800 -39.12600 1.000 306.20521 ? 436 ARG F CB  1 
ATOM 3022 C CG  . ARG A 1 436 ? -61.56900 -21.92200 -38.41200 1.000 314.84633 ? 436 ARG F CG  1 
ATOM 3023 C CD  . ARG A 1 436 ? -61.87000 -22.91000 -39.53800 1.000 324.85689 ? 436 ARG F CD  1 
ATOM 3024 N NE  . ARG A 1 436 ? -62.49400 -24.17100 -39.16500 1.000 334.08231 ? 436 ARG F NE  1 
ATOM 3025 C CZ  . ARG A 1 436 ? -62.71500 -25.16000 -40.02500 1.000 334.92111 ? 436 ARG F CZ  1 
ATOM 3026 N NH1 . ARG A 1 436 ? -62.38300 -25.05600 -41.30300 1.000 337.09209 ? 436 ARG F NH1 1 
ATOM 3027 N NH2 . ARG A 1 436 ? -63.26400 -26.28800 -39.59000 1.000 327.55955 ? 436 ARG F NH2 1 
ATOM 3028 N N   . PRO A 1 437 ? -58.53000 -20.51300 -36.93400 1.000 285.48414 ? 437 PRO F N   1 
ATOM 3029 C CA  . PRO A 1 437 ? -57.17100 -21.06500 -36.75300 1.000 269.27880 ? 437 PRO F CA  1 
ATOM 3030 C C   . PRO A 1 437 ? -56.96000 -22.26600 -37.66400 1.000 268.63641 ? 437 PRO F C   1 
ATOM 3031 O O   . PRO A 1 437 ? -57.80400 -23.15800 -37.75200 1.000 269.14641 ? 437 PRO F O   1 
ATOM 3032 C CB  . PRO A 1 437 ? -57.11900 -21.43400 -35.26900 1.000 277.38026 ? 437 PRO F CB  1 
ATOM 3033 C CG  . PRO A 1 437 ? -58.11000 -20.56300 -34.63900 1.000 285.39127 ? 437 PRO F CG  1 
ATOM 3034 C CD  . PRO A 1 437 ? -59.22500 -20.39200 -35.64300 1.000 291.72894 ? 437 PRO F CD  1 
ATOM 3035 N N   . VAL A 1 454 ? -40.66500 -30.57100 -41.41300 1.000 343.16207 ? 454 VAL F N   1 
ATOM 3036 C CA  . VAL A 1 454 ? -41.17800 -30.78100 -42.76000 1.000 354.92683 ? 454 VAL F CA  1 
ATOM 3037 C C   . VAL A 1 454 ? -41.98200 -29.54300 -43.14400 1.000 354.08264 ? 454 VAL F C   1 
ATOM 3038 O O   . VAL A 1 454 ? -42.42800 -28.77000 -42.29100 1.000 351.75557 ? 454 VAL F O   1 
ATOM 3039 C CB  . VAL A 1 454 ? -42.04400 -32.06400 -42.88800 1.000 354.99003 ? 454 VAL F CB  1 
ATOM 3040 C CG1 . VAL A 1 454 ? -41.25000 -33.29700 -42.44500 1.000 347.04557 ? 454 VAL F CG1 1 
ATOM 3041 C CG2 . VAL A 1 454 ? -43.38900 -31.92500 -42.15500 1.000 353.56010 ? 454 VAL F CG2 1 
ATOM 3042 N N   . ALA A 1 455 ? -42.03300 -29.28200 -44.44500 1.000 352.49646 ? 455 ALA F N   1 
ATOM 3043 C CA  . ALA A 1 455 ? -42.86900 -28.22400 -44.99500 1.000 348.38490 ? 455 ALA F CA  1 
ATOM 3044 C C   . ALA A 1 455 ? -44.35400 -28.49000 -44.74200 1.000 357.91403 ? 455 ALA F C   1 
ATOM 3045 O O   . ALA A 1 455 ? -44.79600 -29.63900 -44.79600 1.000 363.63334 ? 455 ALA F O   1 
ATOM 3046 C CB  . ALA A 1 455 ? -42.60600 -28.09200 -46.49600 1.000 336.03209 ? 455 ALA F CB  1 
ATOM 3047 N N   . LEU A 1 456 ? -45.12700 -27.43400 -44.41300 1.000 354.60875 ? 456 LEU F N   1 
ATOM 3048 C CA  . LEU A 1 456 ? -46.54800 -27.63000 -44.08700 1.000 350.01612 ? 456 LEU F CA  1 
ATOM 3049 C C   . LEU A 1 456 ? -47.23300 -28.24700 -45.28300 1.000 360.32064 ? 456 LEU F C   1 
ATOM 3050 O O   . LEU A 1 456 ? -48.22800 -28.97900 -45.13900 1.000 366.35975 ? 456 LEU F O   1 
ATOM 3051 C CB  . LEU A 1 456 ? -47.24500 -26.32100 -43.68900 1.000 330.32310 ? 456 LEU F CB  1 
ATOM 3052 C CG  . LEU A 1 456 ? -48.74200 -26.17000 -43.41800 1.000 309.49113 ? 456 LEU F CG  1 
ATOM 3053 C CD1 . LEU A 1 456 ? -49.27300 -27.03000 -42.30700 1.000 312.61349 ? 456 LEU F CD1 1 
ATOM 3054 C CD2 . LEU A 1 456 ? -48.95200 -24.70300 -43.08500 1.000 304.85105 ? 456 LEU F CD2 1 
ATOM 3055 N N   . ASP A 1 457 ? -46.76100 -27.88600 -46.47700 1.000 359.36488 ? 457 ASP F N   1 
ATOM 3056 C CA  . ASP A 1 457 ? -47.32400 -28.48500 -47.65800 1.000 354.91019 ? 457 ASP F CA  1 
ATOM 3057 C C   . ASP A 1 457 ? -46.96600 -29.96200 -47.74300 1.000 360.62874 ? 457 ASP F C   1 
ATOM 3058 O O   . ASP A 1 457 ? -47.66200 -30.70600 -48.43600 1.000 359.43757 ? 457 ASP F O   1 
ATOM 3059 C CB  . ASP A 1 457 ? -46.80500 -27.76900 -48.87700 1.000 349.35067 ? 457 ASP F CB  1 
ATOM 3060 C CG  . ASP A 1 457 ? -47.18600 -28.46100 -50.10300 1.000 351.32929 ? 457 ASP F CG  1 
ATOM 3061 O OD1 . ASP A 1 457 ? -48.39800 -28.69400 -50.29400 1.000 348.89290 ? 457 ASP F OD1 1 
ATOM 3062 O OD2 . ASP A 1 457 ? -46.25500 -28.84700 -50.82400 1.000 352.79554 ? 457 ASP F OD2 1 
ATOM 3063 N N   . GLN A 1 458 ? -45.92500 -30.41400 -47.01800 1.000 360.77045 ? 458 GLN F N   1 
ATOM 3064 C CA  . GLN A 1 458 ? -45.65500 -31.84900 -46.91500 1.000 363.32347 ? 458 GLN F CA  1 
ATOM 3065 C C   . GLN A 1 458 ? -46.60400 -32.55000 -45.94800 1.000 377.62902 ? 458 GLN F C   1 
ATOM 3066 O O   . GLN A 1 458 ? -46.78400 -33.76700 -46.04900 1.000 385.01748 ? 458 GLN F O   1 
ATOM 3067 C CB  . GLN A 1 458 ? -44.25600 -32.11300 -46.41100 1.000 351.27358 ? 458 GLN F CB  1 
ATOM 3068 C CG  . GLN A 1 458 ? -43.18600 -31.52000 -47.19300 1.000 341.94894 ? 458 GLN F CG  1 
ATOM 3069 C CD  . GLN A 1 458 ? -41.91500 -31.86500 -46.53000 1.000 344.73485 ? 458 GLN F CD  1 
ATOM 3070 O OE1 . GLN A 1 458 ? -40.96500 -31.08700 -46.52000 1.000 348.36586 ? 458 GLN F OE1 1 
ATOM 3071 N NE2 . GLN A 1 458 ? -41.91400 -33.01800 -45.87400 1.000 344.26783 ? 458 GLN F NE2 1 
ATOM 3072 N N   . VAL A 1 459 ? -47.15000 -31.82100 -44.96400 1.000 381.12589 ? 459 VAL F N   1 
ATOM 3073 C CA  . VAL A 1 459 ? -48.22700 -32.33800 -44.11200 1.000 375.42740 ? 459 VAL F CA  1 
ATOM 3074 C C   . VAL A 1 459 ? -49.53400 -32.46600 -44.92500 1.000 382.32504 ? 459 VAL F C   1 
ATOM 3075 O O   . VAL A 1 459 ? -50.24400 -33.48400 -44.81700 1.000 383.80543 ? 459 VAL F O   1 
ATOM 3076 C CB  . VAL A 1 459 ? -48.33600 -31.51600 -42.81600 1.000 349.79548 ? 459 VAL F CB  1 
ATOM 3077 C CG1 . VAL A 1 459 ? -49.54200 -31.93700 -42.00600 1.000 334.44783 ? 459 VAL F CG1 1 
ATOM 3078 C CG2 . VAL A 1 459 ? -47.04800 -31.72500 -42.02700 1.000 336.11923 ? 459 VAL F CG2 1 
ATOM 3079 N N   . PHE A 1 460 ? -49.90200 -31.42000 -45.72300 1.000 382.63696 ? 460 PHE F N   1 
ATOM 3080 C CA  . PHE A 1 460 ? -51.07300 -31.57400 -46.61600 1.000 379.44780 ? 460 PHE F CA  1 
ATOM 3081 C C   . PHE A 1 460 ? -50.84100 -32.70000 -47.62100 1.000 387.14502 ? 460 PHE F C   1 
ATOM 3082 O O   . PHE A 1 460 ? -51.76800 -33.46300 -47.93300 1.000 389.80758 ? 460 PHE F O   1 
ATOM 3083 C CB  . PHE A 1 460 ? -51.40500 -30.32000 -47.46300 1.000 369.47648 ? 460 PHE F CB  1 
ATOM 3084 C CG  . PHE A 1 460 ? -51.94500 -29.13100 -46.72700 1.000 354.55258 ? 460 PHE F CG  1 
ATOM 3085 C CD1 . PHE A 1 460 ? -53.16700 -29.21000 -46.09300 1.000 350.12463 ? 460 PHE F CD1 1 
ATOM 3086 C CD2 . PHE A 1 460 ? -51.31000 -27.90900 -46.78200 1.000 340.97112 ? 460 PHE F CD2 1 
ATOM 3087 C CE1 . PHE A 1 460 ? -53.70600 -28.11900 -45.46600 1.000 333.66736 ? 460 PHE F CE1 1 
ATOM 3088 C CE2 . PHE A 1 460 ? -51.84700 -26.81900 -46.14400 1.000 325.91384 ? 460 PHE F CE2 1 
ATOM 3089 C CZ  . PHE A 1 460 ? -53.04500 -26.93000 -45.48600 1.000 320.04834 ? 460 PHE F CZ  1 
ATOM 3090 N N   . GLU A 1 461 ? -49.61400 -32.79200 -48.16400 1.000 385.72316 ? 461 GLU F N   1 
ATOM 3091 C CA  . GLU A 1 461 ? -49.25600 -33.85500 -49.09900 1.000 382.89789 ? 461 GLU F CA  1 
ATOM 3092 C C   . GLU A 1 461 ? -49.31800 -35.24800 -48.45400 1.000 395.05698 ? 461 GLU F C   1 
ATOM 3093 O O   . GLU A 1 461 ? -49.76800 -36.20200 -49.09500 1.000 399.66707 ? 461 GLU F O   1 
ATOM 3094 C CB  . GLU A 1 461 ? -47.83800 -33.57900 -49.62100 1.000 368.00882 ? 461 GLU F CB  1 
ATOM 3095 C CG  . GLU A 1 461 ? -47.37000 -34.34700 -50.83000 1.000 359.50190 ? 461 GLU F CG  1 
ATOM 3096 C CD  . GLU A 1 461 ? -45.89400 -34.11300 -51.08300 1.000 355.88180 ? 461 GLU F CD  1 
ATOM 3097 O OE1 . GLU A 1 461 ? -45.09600 -34.29900 -50.13500 1.000 347.53273 ? 461 GLU F OE1 1 
ATOM 3098 O OE2 . GLU A 1 461 ? -45.52700 -33.75700 -52.21800 1.000 354.77886 ? 461 GLU F OE2 1 
ATOM 3099 N N   . SER A 1 462 ? -48.89700 -35.38400 -47.17300 1.000 401.04291 ? 462 SER F N   1 
ATOM 3100 C CA  . SER A 1 462 ? -48.95100 -36.67400 -46.46100 1.000 405.22179 ? 462 SER F CA  1 
ATOM 3101 C C   . SER A 1 462 ? -50.39600 -37.15200 -46.19600 1.000 410.77389 ? 462 SER F C   1 
ATOM 3102 O O   . SER A 1 462 ? -50.72900 -38.32300 -46.46200 1.000 416.77312 ? 462 SER F O   1 
ATOM 3103 C CB  . SER A 1 462 ? -48.11800 -36.56800 -45.16800 1.000 408.43604 ? 462 SER F CB  1 
ATOM 3104 O OG  . SER A 1 462 ? -48.08900 -37.77000 -44.41400 1.000 412.33562 ? 462 SER F OG  1 
ATOM 3105 N N   . ILE A 1 463 ? -51.28200 -36.24200 -45.73700 1.000 405.58604 ? 463 ILE F N   1 
ATOM 3106 C CA  . ILE A 1 463 ? -52.69900 -36.57900 -45.49100 1.000 398.50834 ? 463 ILE F CA  1 
ATOM 3107 C C   . ILE A 1 463 ? -53.40500 -36.93000 -46.80400 1.000 402.00638 ? 463 ILE F C   1 
ATOM 3108 O O   . ILE A 1 463 ? -54.08800 -37.97600 -46.93800 1.000 402.43280 ? 463 ILE F O   1 
ATOM 3109 C CB  . ILE A 1 463 ? -53.38000 -35.41900 -44.73600 1.000 377.93469 ? 463 ILE F CB  1 
ATOM 3110 C CG1 . ILE A 1 463 ? -52.57000 -35.10400 -43.48700 1.000 364.70216 ? 463 ILE F CG1 1 
ATOM 3111 C CG2 . ILE A 1 463 ? -54.85900 -35.62400 -44.50700 1.000 370.76014 ? 463 ILE F CG2 1 
ATOM 3112 C CD1 . ILE A 1 463 ? -52.88400 -33.86200 -42.90000 1.000 358.32503 ? 463 ILE F CD1 1 
ATOM 3113 N N   . GLU A 1 464 ? -53.15900 -36.09400 -47.81800 1.000 399.64064 ? 464 GLU F N   1 
ATOM 3114 C CA  . GLU A 1 464 ? -53.77600 -36.19900 -49.12800 1.000 391.67598 ? 464 GLU F CA  1 
ATOM 3115 C C   . GLU A 1 464 ? -53.30900 -37.50000 -49.81200 1.000 396.96642 ? 464 GLU F C   1 
ATOM 3116 O O   . GLU A 1 464 ? -54.09300 -38.13200 -50.53300 1.000 388.05773 ? 464 GLU F O   1 
ATOM 3117 C CB  . GLU A 1 464 ? -53.48600 -34.86400 -49.83500 1.000 377.39288 ? 464 GLU F CB  1 
ATOM 3118 C CG  . GLU A 1 464 ? -53.88500 -34.55500 -51.23400 1.000 357.92956 ? 464 GLU F CG  1 
ATOM 3119 C CD  . GLU A 1 464 ? -53.61400 -33.07800 -51.49100 1.000 342.99547 ? 464 GLU F CD  1 
ATOM 3120 O OE1 . GLU A 1 464 ? -53.04600 -32.41500 -50.60000 1.000 347.41534 ? 464 GLU F OE1 1 
ATOM 3121 O OE2 . GLU A 1 464 ? -53.98800 -32.56400 -52.55100 1.000 334.96631 ? 464 GLU F OE2 1 
ATOM 3122 N N   . ASN A 1 465 ? -52.02600 -37.90500 -49.62100 1.000 403.01640 ? 465 ASN F N   1 
ATOM 3123 C CA  . ASN A 1 465 ? -51.53100 -39.16500 -50.20000 1.000 398.39141 ? 465 ASN F CA  1 
ATOM 3124 C C   . ASN A 1 465 ? -52.15400 -40.38500 -49.50800 1.000 399.36640 ? 465 ASN F C   1 
ATOM 3125 O O   . ASN A 1 465 ? -52.54600 -41.34300 -50.18700 1.000 396.21148 ? 465 ASN F O   1 
ATOM 3126 C CB  . ASN A 1 465 ? -49.99500 -39.31900 -50.03200 1.000 395.75060 ? 465 ASN F CB  1 
ATOM 3127 C CG  . ASN A 1 465 ? -49.15500 -38.52100 -51.02600 1.000 391.73567 ? 465 ASN F CG  1 
ATOM 3128 O OD1 . ASN A 1 465 ? -49.66100 -37.76500 -51.84100 1.000 395.30692 ? 465 ASN F OD1 1 
ATOM 3129 N ND2 . ASN A 1 465 ? -47.83500 -38.69400 -50.93600 1.000 384.94294 ? 465 ASN F ND2 1 
ATOM 3130 N N   . SER A 1 466 ? -52.24000 -40.38700 -48.16000 1.000 402.63977 ? 466 SER F N   1 
ATOM 3131 C CA  . SER A 1 466 ? -52.78000 -41.56600 -47.45700 1.000 396.39652 ? 466 SER F CA  1 
ATOM 3132 C C   . SER A 1 466 ? -54.26600 -41.87700 -47.69300 1.000 384.31467 ? 466 SER F C   1 
ATOM 3133 O O   . SER A 1 466 ? -54.66600 -43.02500 -47.44900 1.000 380.89003 ? 466 SER F O   1 
ATOM 3134 C CB  . SER A 1 466 ? -52.56200 -41.46400 -45.93700 1.000 401.53102 ? 466 SER F CB  1 
ATOM 3135 O OG  . SER A 1 466 ? -53.27100 -40.38500 -45.35200 1.000 404.56732 ? 466 SER F OG  1 
ATOM 3136 N N   . GLN A 1 467 ? -55.12600 -40.90500 -48.05900 1.000 379.64976 ? 467 GLN F N   1 
ATOM 3137 C CA  . GLN A 1 467 ? -56.52000 -41.35700 -48.26400 1.000 371.12563 ? 467 GLN F CA  1 
ATOM 3138 C C   . GLN A 1 467 ? -56.96000 -41.89000 -49.65700 1.000 368.93628 ? 467 GLN F C   1 
ATOM 3139 O O   . GLN A 1 467 ? -57.85700 -42.74400 -49.70300 1.000 371.03862 ? 467 GLN F O   1 
ATOM 3140 C CB  . GLN A 1 467 ? -57.50100 -40.27400 -47.82200 1.000 366.97973 ? 467 GLN F CB  1 
ATOM 3141 C CG  . GLN A 1 467 ? -58.92500 -40.80200 -47.79500 1.000 358.38175 ? 467 GLN F CG  1 
ATOM 3142 C CD  . GLN A 1 467 ? -59.08800 -41.95400 -46.81100 1.000 348.26186 ? 467 GLN F CD  1 
ATOM 3143 O OE1 . GLN A 1 467 ? -58.30100 -42.11300 -45.87600 1.000 348.27144 ? 467 GLN F OE1 1 
ATOM 3144 N NE2 . GLN A 1 467 ? -60.11000 -42.77000 -47.03100 1.000 342.82324 ? 467 GLN F NE2 1 
ATOM 3145 N N   . ALA A 1 468 ? -56.39400 -41.46400 -50.79300 1.000 363.69530 ? 468 ALA F N   1 
ATOM 3146 C CA  . ALA A 1 468 ? -56.85800 -42.00000 -52.11000 1.000 342.90144 ? 468 ALA F CA  1 
ATOM 3147 C C   . ALA A 1 468 ? -56.55700 -43.47000 -52.41400 1.000 332.43746 ? 468 ALA F C   1 
ATOM 3148 O O   . ALA A 1 468 ? -57.03800 -44.01500 -53.41600 1.000 310.72124 ? 468 ALA F O   1 
ATOM 3149 C CB  . ALA A 1 468 ? -56.30600 -41.14500 -53.24000 1.000 328.78844 ? 468 ALA F CB  1 
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