data_8W3L
# 
_entry.id   8W3L 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W3L         pdb_00008w3l 10.2210/pdb8w3l/pdb 
WWPDB D_1000280348 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W3L 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jiang@scripps.edu 
_pdbx_contact_author.name_first         JIANG 
_pdbx_contact_author.name_last          ZHU 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0259-7157 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lee, Y.Z.'       1 ? 
'Stanfield, R.L.' 2 ? 
'Wilson, I.A.'    3 ? 
'Zhu, J.'         4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9939 
_citation.page_last                 9939 
_citation.title                     
'Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54287-x 
_citation.pdbx_database_id_PubMed   39550381 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lee, Y.Z.'       1  0000-0002-5651-863X 
primary 'Han, J.'         2  ?                   
primary 'Zhang, Y.N.'     3  0000-0001-9053-5890 
primary 'Ward, G.'        4  ?                   
primary 'Braz Gomes, K.'  5  ?                   
primary 'Auclair, S.'     6  ?                   
primary 'Stanfield, R.L.' 7  ?                   
primary 'He, L.'          8  ?                   
primary 'Wilson, I.A.'    9  0000-0002-6469-2419 
primary 'Zhu, J.'         10 0000-0003-0259-7157 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'prefusion-stabilized RSV F protein UFCR2-iSS-P2-NQ' 55649.660 1  ? ? ? ? 
2 non-polymer syn 1,2-ETHANEDIOL                                       62.068    3  ? ? ? ? 
3 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose             221.208   1  ? ? ? ? 
4 water       nat water                                                18.015    79 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGPSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSNQFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGPSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSNQFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_strand_id                 F 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1,2-ETHANEDIOL                           EDO 
3 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
4 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   ILE n 
1 4   LEU n 
1 5   PRO n 
1 6   SER n 
1 7   PRO n 
1 8   GLY n 
1 9   MET n 
1 10  PRO n 
1 11  ALA n 
1 12  LEU n 
1 13  LEU n 
1 14  SER n 
1 15  LEU n 
1 16  VAL n 
1 17  SER n 
1 18  LEU n 
1 19  LEU n 
1 20  SER n 
1 21  VAL n 
1 22  LEU n 
1 23  LEU n 
1 24  MET n 
1 25  GLY n 
1 26  CYS n 
1 27  VAL n 
1 28  ALA n 
1 29  GLU n 
1 30  GLN n 
1 31  ASN n 
1 32  ILE n 
1 33  THR n 
1 34  GLU n 
1 35  GLU n 
1 36  PHE n 
1 37  TYR n 
1 38  GLN n 
1 39  SER n 
1 40  THR n 
1 41  CYS n 
1 42  SER n 
1 43  ALA n 
1 44  VAL n 
1 45  SER n 
1 46  LYS n 
1 47  GLY n 
1 48  TYR n 
1 49  LEU n 
1 50  GLY n 
1 51  ALA n 
1 52  LEU n 
1 53  ARG n 
1 54  THR n 
1 55  GLY n 
1 56  TRP n 
1 57  TYR n 
1 58  THR n 
1 59  SER n 
1 60  VAL n 
1 61  ILE n 
1 62  THR n 
1 63  ILE n 
1 64  GLU n 
1 65  LEU n 
1 66  SER n 
1 67  ASN n 
1 68  ILE n 
1 69  LYS n 
1 70  GLU n 
1 71  ASN n 
1 72  LYS n 
1 73  CYS n 
1 74  ASN n 
1 75  GLY n 
1 76  THR n 
1 77  ASP n 
1 78  ALA n 
1 79  LYS n 
1 80  VAL n 
1 81  LYS n 
1 82  LEU n 
1 83  ILE n 
1 84  LYS n 
1 85  GLN n 
1 86  GLU n 
1 87  LEU n 
1 88  ASP n 
1 89  LYS n 
1 90  TYR n 
1 91  LYS n 
1 92  ASN n 
1 93  ALA n 
1 94  VAL n 
1 95  THR n 
1 96  ASP n 
1 97  LEU n 
1 98  GLN n 
1 99  LEU n 
1 100 LEU n 
1 101 MET n 
1 102 GLN n 
1 103 SER n 
1 104 THR n 
1 105 PRO n 
1 106 ALA n 
1 107 THR n 
1 108 GLY n 
1 109 SER n 
1 110 GLY n 
1 111 SER n 
1 112 ALA n 
1 113 ILE n 
1 114 CYS n 
1 115 SER n 
1 116 GLY n 
1 117 VAL n 
1 118 ALA n 
1 119 VAL n 
1 120 CYS n 
1 121 LYS n 
1 122 VAL n 
1 123 LEU n 
1 124 HIS n 
1 125 LEU n 
1 126 GLU n 
1 127 GLY n 
1 128 GLU n 
1 129 VAL n 
1 130 ASN n 
1 131 LYS n 
1 132 ILE n 
1 133 LYS n 
1 134 SER n 
1 135 ALA n 
1 136 LEU n 
1 137 LEU n 
1 138 SER n 
1 139 THR n 
1 140 ASN n 
1 141 LYS n 
1 142 ALA n 
1 143 VAL n 
1 144 VAL n 
1 145 SER n 
1 146 LEU n 
1 147 SER n 
1 148 ASN n 
1 149 GLY n 
1 150 PRO n 
1 151 SER n 
1 152 VAL n 
1 153 LEU n 
1 154 THR n 
1 155 SER n 
1 156 LYS n 
1 157 VAL n 
1 158 LEU n 
1 159 ASP n 
1 160 LEU n 
1 161 LYS n 
1 162 ASN n 
1 163 TYR n 
1 164 ILE n 
1 165 ASP n 
1 166 LYS n 
1 167 GLN n 
1 168 LEU n 
1 169 LEU n 
1 170 PRO n 
1 171 ILE n 
1 172 VAL n 
1 173 ASN n 
1 174 LYS n 
1 175 GLN n 
1 176 SER n 
1 177 CYS n 
1 178 SER n 
1 179 ILE n 
1 180 PRO n 
1 181 ASN n 
1 182 ILE n 
1 183 GLU n 
1 184 THR n 
1 185 VAL n 
1 186 ILE n 
1 187 GLU n 
1 188 PHE n 
1 189 GLN n 
1 190 GLN n 
1 191 LYS n 
1 192 ASN n 
1 193 ASN n 
1 194 ARG n 
1 195 LEU n 
1 196 LEU n 
1 197 GLU n 
1 198 ILE n 
1 199 THR n 
1 200 ARG n 
1 201 GLU n 
1 202 PHE n 
1 203 SER n 
1 204 VAL n 
1 205 ASN n 
1 206 ALA n 
1 207 GLY n 
1 208 VAL n 
1 209 THR n 
1 210 THR n 
1 211 PRO n 
1 212 VAL n 
1 213 SER n 
1 214 THR n 
1 215 TYR n 
1 216 MET n 
1 217 LEU n 
1 218 THR n 
1 219 ASN n 
1 220 SER n 
1 221 GLU n 
1 222 LEU n 
1 223 LEU n 
1 224 SER n 
1 225 LEU n 
1 226 ILE n 
1 227 ASN n 
1 228 ASP n 
1 229 MET n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 ASN n 
1 234 ASP n 
1 235 GLN n 
1 236 LYS n 
1 237 LYS n 
1 238 LEU n 
1 239 MET n 
1 240 SER n 
1 241 ASN n 
1 242 ASN n 
1 243 VAL n 
1 244 GLN n 
1 245 ILE n 
1 246 VAL n 
1 247 ARG n 
1 248 GLN n 
1 249 GLN n 
1 250 SER n 
1 251 TYR n 
1 252 SER n 
1 253 ILE n 
1 254 MET n 
1 255 CYS n 
1 256 ILE n 
1 257 ILE n 
1 258 LYS n 
1 259 GLU n 
1 260 GLU n 
1 261 VAL n 
1 262 LEU n 
1 263 ALA n 
1 264 TYR n 
1 265 VAL n 
1 266 VAL n 
1 267 GLN n 
1 268 LEU n 
1 269 PRO n 
1 270 LEU n 
1 271 TYR n 
1 272 GLY n 
1 273 VAL n 
1 274 ILE n 
1 275 ASP n 
1 276 THR n 
1 277 PRO n 
1 278 CYS n 
1 279 TRP n 
1 280 LYS n 
1 281 LEU n 
1 282 HIS n 
1 283 THR n 
1 284 SER n 
1 285 PRO n 
1 286 LEU n 
1 287 CYS n 
1 288 THR n 
1 289 THR n 
1 290 ASN n 
1 291 THR n 
1 292 LYS n 
1 293 GLU n 
1 294 GLY n 
1 295 SER n 
1 296 ASN n 
1 297 ILE n 
1 298 CYS n 
1 299 LEU n 
1 300 THR n 
1 301 ARG n 
1 302 THR n 
1 303 ASP n 
1 304 ARG n 
1 305 GLY n 
1 306 TRP n 
1 307 TYR n 
1 308 CYS n 
1 309 ASP n 
1 310 ASN n 
1 311 ALA n 
1 312 GLY n 
1 313 SER n 
1 314 VAL n 
1 315 SER n 
1 316 PHE n 
1 317 PHE n 
1 318 PRO n 
1 319 GLN n 
1 320 ALA n 
1 321 GLU n 
1 322 THR n 
1 323 CYS n 
1 324 LYS n 
1 325 VAL n 
1 326 GLN n 
1 327 SER n 
1 328 ASN n 
1 329 ARG n 
1 330 VAL n 
1 331 PHE n 
1 332 CYS n 
1 333 ASP n 
1 334 THR n 
1 335 MET n 
1 336 ASN n 
1 337 SER n 
1 338 LEU n 
1 339 THR n 
1 340 LEU n 
1 341 PRO n 
1 342 SER n 
1 343 GLU n 
1 344 VAL n 
1 345 ASN n 
1 346 LEU n 
1 347 CYS n 
1 348 ASN n 
1 349 VAL n 
1 350 ASP n 
1 351 ILE n 
1 352 PHE n 
1 353 ASN n 
1 354 PRO n 
1 355 LYS n 
1 356 TYR n 
1 357 ASP n 
1 358 CYS n 
1 359 LYS n 
1 360 ILE n 
1 361 MET n 
1 362 THR n 
1 363 SER n 
1 364 LYS n 
1 365 THR n 
1 366 ASP n 
1 367 VAL n 
1 368 SER n 
1 369 SER n 
1 370 SER n 
1 371 VAL n 
1 372 ILE n 
1 373 THR n 
1 374 SER n 
1 375 LEU n 
1 376 GLY n 
1 377 ALA n 
1 378 ILE n 
1 379 VAL n 
1 380 SER n 
1 381 CYS n 
1 382 TYR n 
1 383 GLY n 
1 384 LYS n 
1 385 THR n 
1 386 LYS n 
1 387 CYS n 
1 388 THR n 
1 389 ALA n 
1 390 SER n 
1 391 ASN n 
1 392 LYS n 
1 393 ASN n 
1 394 ARG n 
1 395 GLY n 
1 396 ILE n 
1 397 ILE n 
1 398 LYS n 
1 399 THR n 
1 400 PHE n 
1 401 SER n 
1 402 ASN n 
1 403 GLY n 
1 404 CYS n 
1 405 ASP n 
1 406 TYR n 
1 407 VAL n 
1 408 SER n 
1 409 ASN n 
1 410 LYS n 
1 411 GLY n 
1 412 VAL n 
1 413 ASP n 
1 414 THR n 
1 415 VAL n 
1 416 SER n 
1 417 VAL n 
1 418 GLY n 
1 419 ASN n 
1 420 THR n 
1 421 LEU n 
1 422 TYR n 
1 423 CYS n 
1 424 VAL n 
1 425 ASN n 
1 426 LYS n 
1 427 GLN n 
1 428 GLU n 
1 429 GLY n 
1 430 GLN n 
1 431 SER n 
1 432 LEU n 
1 433 TYR n 
1 434 VAL n 
1 435 LYS n 
1 436 GLY n 
1 437 GLU n 
1 438 PRO n 
1 439 ILE n 
1 440 ILE n 
1 441 ASN n 
1 442 PHE n 
1 443 TYR n 
1 444 ASP n 
1 445 PRO n 
1 446 LEU n 
1 447 VAL n 
1 448 PHE n 
1 449 PRO n 
1 450 SER n 
1 451 ASN n 
1 452 GLN n 
1 453 PHE n 
1 454 ASP n 
1 455 ALA n 
1 456 SER n 
1 457 ILE n 
1 458 SER n 
1 459 GLN n 
1 460 VAL n 
1 461 ASN n 
1 462 GLU n 
1 463 LYS n 
1 464 ILE n 
1 465 ASN n 
1 466 GLN n 
1 467 SER n 
1 468 LEU n 
1 469 ALA n 
1 470 PHE n 
1 471 ILE n 
1 472 ARG n 
1 473 LYS n 
1 474 SER n 
1 475 ASP n 
1 476 GLU n 
1 477 LEU n 
1 478 LEU n 
1 479 ALA n 
1 480 SER n 
1 481 GLY n 
1 482 TYR n 
1 483 ILE n 
1 484 PRO n 
1 485 GLU n 
1 486 ALA n 
1 487 PRO n 
1 488 ARG n 
1 489 ASP n 
1 490 GLY n 
1 491 GLN n 
1 492 ALA n 
1 493 TYR n 
1 494 VAL n 
1 495 ARG n 
1 496 LYS n 
1 497 ASP n 
1 498 GLY n 
1 499 GLU n 
1 500 TRP n 
1 501 VAL n 
1 502 LEU n 
1 503 LEU n 
1 504 SER n 
1 505 THR n 
1 506 PHE n 
1 507 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   507 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Human respiratory syncytial virus A2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11259 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
EDO non-polymer                  . 1,2-ETHANEDIOL                           'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -3  ?   ?   ?   F . n 
A 1 2   GLY 2   -2  ?   ?   ?   F . n 
A 1 3   ILE 3   -1  ?   ?   ?   F . n 
A 1 4   LEU 4   0   ?   ?   ?   F . n 
A 1 5   PRO 5   1   ?   ?   ?   F . n 
A 1 6   SER 6   2   ?   ?   ?   F . n 
A 1 7   PRO 7   3   ?   ?   ?   F . n 
A 1 8   GLY 8   4   ?   ?   ?   F . n 
A 1 9   MET 9   5   ?   ?   ?   F . n 
A 1 10  PRO 10  6   ?   ?   ?   F . n 
A 1 11  ALA 11  7   ?   ?   ?   F . n 
A 1 12  LEU 12  8   ?   ?   ?   F . n 
A 1 13  LEU 13  9   ?   ?   ?   F . n 
A 1 14  SER 14  10  ?   ?   ?   F . n 
A 1 15  LEU 15  11  ?   ?   ?   F . n 
A 1 16  VAL 16  12  ?   ?   ?   F . n 
A 1 17  SER 17  13  ?   ?   ?   F . n 
A 1 18  LEU 18  14  ?   ?   ?   F . n 
A 1 19  LEU 19  15  ?   ?   ?   F . n 
A 1 20  SER 20  16  ?   ?   ?   F . n 
A 1 21  VAL 21  17  ?   ?   ?   F . n 
A 1 22  LEU 22  18  ?   ?   ?   F . n 
A 1 23  LEU 23  19  ?   ?   ?   F . n 
A 1 24  MET 24  20  ?   ?   ?   F . n 
A 1 25  GLY 25  21  ?   ?   ?   F . n 
A 1 26  CYS 26  22  ?   ?   ?   F . n 
A 1 27  VAL 27  23  ?   ?   ?   F . n 
A 1 28  ALA 28  24  ?   ?   ?   F . n 
A 1 29  GLU 29  25  ?   ?   ?   F . n 
A 1 30  GLN 30  26  26  GLN GLN F . n 
A 1 31  ASN 31  27  27  ASN ASN F . n 
A 1 32  ILE 32  28  28  ILE ILE F . n 
A 1 33  THR 33  29  29  THR THR F . n 
A 1 34  GLU 34  30  30  GLU GLU F . n 
A 1 35  GLU 35  31  31  GLU GLU F . n 
A 1 36  PHE 36  32  32  PHE PHE F . n 
A 1 37  TYR 37  33  33  TYR TYR F . n 
A 1 38  GLN 38  34  34  GLN GLN F . n 
A 1 39  SER 39  35  35  SER SER F . n 
A 1 40  THR 40  36  36  THR THR F . n 
A 1 41  CYS 41  37  37  CYS CYS F . n 
A 1 42  SER 42  38  38  SER SER F . n 
A 1 43  ALA 43  39  39  ALA ALA F . n 
A 1 44  VAL 44  40  40  VAL VAL F . n 
A 1 45  SER 45  41  41  SER SER F . n 
A 1 46  LYS 46  42  42  LYS LYS F . n 
A 1 47  GLY 47  43  43  GLY GLY F . n 
A 1 48  TYR 48  44  44  TYR TYR F . n 
A 1 49  LEU 49  45  45  LEU LEU F . n 
A 1 50  GLY 50  46  46  GLY GLY F . n 
A 1 51  ALA 51  47  47  ALA ALA F . n 
A 1 52  LEU 52  48  48  LEU LEU F . n 
A 1 53  ARG 53  49  49  ARG ARG F . n 
A 1 54  THR 54  50  50  THR THR F . n 
A 1 55  GLY 55  51  51  GLY GLY F . n 
A 1 56  TRP 56  52  52  TRP TRP F . n 
A 1 57  TYR 57  53  53  TYR TYR F . n 
A 1 58  THR 58  54  54  THR THR F . n 
A 1 59  SER 59  55  55  SER SER F . n 
A 1 60  VAL 60  56  56  VAL VAL F . n 
A 1 61  ILE 61  57  57  ILE ILE F . n 
A 1 62  THR 62  58  58  THR THR F . n 
A 1 63  ILE 63  59  59  ILE ILE F . n 
A 1 64  GLU 64  60  60  GLU GLU F . n 
A 1 65  LEU 65  61  61  LEU LEU F . n 
A 1 66  SER 66  62  62  SER SER F . n 
A 1 67  ASN 67  63  63  ASN ASN F . n 
A 1 68  ILE 68  64  64  ILE ILE F . n 
A 1 69  LYS 69  65  65  LYS LYS F . n 
A 1 70  GLU 70  66  66  GLU GLU F . n 
A 1 71  ASN 71  67  67  ASN ASN F . n 
A 1 72  LYS 72  68  68  LYS LYS F . n 
A 1 73  CYS 73  69  69  CYS CYS F . n 
A 1 74  ASN 74  70  70  ASN ASN F . n 
A 1 75  GLY 75  71  71  GLY GLY F . n 
A 1 76  THR 76  72  72  THR THR F . n 
A 1 77  ASP 77  73  73  ASP ASP F . n 
A 1 78  ALA 78  74  74  ALA ALA F . n 
A 1 79  LYS 79  75  75  LYS LYS F . n 
A 1 80  VAL 80  76  76  VAL VAL F . n 
A 1 81  LYS 81  77  77  LYS LYS F . n 
A 1 82  LEU 82  78  78  LEU LEU F . n 
A 1 83  ILE 83  79  79  ILE ILE F . n 
A 1 84  LYS 84  80  80  LYS LYS F . n 
A 1 85  GLN 85  81  81  GLN GLN F . n 
A 1 86  GLU 86  82  82  GLU GLU F . n 
A 1 87  LEU 87  83  83  LEU LEU F . n 
A 1 88  ASP 88  84  84  ASP ASP F . n 
A 1 89  LYS 89  85  85  LYS LYS F . n 
A 1 90  TYR 90  86  86  TYR TYR F . n 
A 1 91  LYS 91  87  87  LYS LYS F . n 
A 1 92  ASN 92  88  88  ASN ASN F . n 
A 1 93  ALA 93  89  89  ALA ALA F . n 
A 1 94  VAL 94  90  90  VAL VAL F . n 
A 1 95  THR 95  91  91  THR THR F . n 
A 1 96  ASP 96  92  92  ASP ASP F . n 
A 1 97  LEU 97  93  93  LEU LEU F . n 
A 1 98  GLN 98  94  94  GLN GLN F . n 
A 1 99  LEU 99  95  95  LEU LEU F . n 
A 1 100 LEU 100 96  96  LEU LEU F . n 
A 1 101 MET 101 97  97  MET MET F . n 
A 1 102 GLN 102 98  98  GLN GLN F . n 
A 1 103 SER 103 99  99  SER SER F . n 
A 1 104 THR 104 100 100 THR THR F . n 
A 1 105 PRO 105 101 101 PRO PRO F . n 
A 1 106 ALA 106 102 102 ALA ALA F . n 
A 1 107 THR 107 103 103 THR THR F . n 
A 1 108 GLY 108 143 143 GLY GLY F . n 
A 1 109 SER 109 144 144 SER SER F . n 
A 1 110 GLY 110 145 145 GLY GLY F . n 
A 1 111 SER 111 146 146 SER SER F . n 
A 1 112 ALA 112 147 147 ALA ALA F . n 
A 1 113 ILE 113 148 148 ILE ILE F . n 
A 1 114 CYS 114 149 149 CYS CYS F . n 
A 1 115 SER 115 150 150 SER SER F . n 
A 1 116 GLY 116 151 151 GLY GLY F . n 
A 1 117 VAL 117 152 152 VAL VAL F . n 
A 1 118 ALA 118 153 153 ALA ALA F . n 
A 1 119 VAL 119 154 154 VAL VAL F . n 
A 1 120 CYS 120 155 155 CYS CYS F . n 
A 1 121 LYS 121 156 156 LYS LYS F . n 
A 1 122 VAL 122 157 157 VAL VAL F . n 
A 1 123 LEU 123 158 158 LEU LEU F . n 
A 1 124 HIS 124 159 159 HIS HIS F . n 
A 1 125 LEU 125 160 160 LEU LEU F . n 
A 1 126 GLU 126 161 161 GLU GLU F . n 
A 1 127 GLY 127 162 162 GLY GLY F . n 
A 1 128 GLU 128 163 163 GLU GLU F . n 
A 1 129 VAL 129 164 164 VAL VAL F . n 
A 1 130 ASN 130 165 165 ASN ASN F . n 
A 1 131 LYS 131 166 166 LYS LYS F . n 
A 1 132 ILE 132 167 167 ILE ILE F . n 
A 1 133 LYS 133 168 168 LYS LYS F . n 
A 1 134 SER 134 169 169 SER SER F . n 
A 1 135 ALA 135 170 170 ALA ALA F . n 
A 1 136 LEU 136 171 171 LEU LEU F . n 
A 1 137 LEU 137 172 172 LEU LEU F . n 
A 1 138 SER 138 173 173 SER SER F . n 
A 1 139 THR 139 174 174 THR THR F . n 
A 1 140 ASN 140 175 175 ASN ASN F . n 
A 1 141 LYS 141 176 176 LYS LYS F . n 
A 1 142 ALA 142 177 177 ALA ALA F . n 
A 1 143 VAL 143 178 178 VAL VAL F . n 
A 1 144 VAL 144 179 179 VAL VAL F . n 
A 1 145 SER 145 180 180 SER SER F . n 
A 1 146 LEU 146 181 181 LEU LEU F . n 
A 1 147 SER 147 182 182 SER SER F . n 
A 1 148 ASN 148 183 183 ASN ASN F . n 
A 1 149 GLY 149 184 184 GLY GLY F . n 
A 1 150 PRO 150 185 185 PRO PRO F . n 
A 1 151 SER 151 186 186 SER SER F . n 
A 1 152 VAL 152 187 187 VAL VAL F . n 
A 1 153 LEU 153 188 188 LEU LEU F . n 
A 1 154 THR 154 189 189 THR THR F . n 
A 1 155 SER 155 190 190 SER SER F . n 
A 1 156 LYS 156 191 191 LYS LYS F . n 
A 1 157 VAL 157 192 192 VAL VAL F . n 
A 1 158 LEU 158 193 193 LEU LEU F . n 
A 1 159 ASP 159 194 194 ASP ASP F . n 
A 1 160 LEU 160 195 195 LEU LEU F . n 
A 1 161 LYS 161 196 196 LYS LYS F . n 
A 1 162 ASN 162 197 197 ASN ASN F . n 
A 1 163 TYR 163 198 198 TYR TYR F . n 
A 1 164 ILE 164 199 199 ILE ILE F . n 
A 1 165 ASP 165 200 200 ASP ASP F . n 
A 1 166 LYS 166 201 201 LYS LYS F . n 
A 1 167 GLN 167 202 202 GLN GLN F . n 
A 1 168 LEU 168 203 203 LEU LEU F . n 
A 1 169 LEU 169 204 204 LEU LEU F . n 
A 1 170 PRO 170 205 205 PRO PRO F . n 
A 1 171 ILE 171 206 206 ILE ILE F . n 
A 1 172 VAL 172 207 207 VAL VAL F . n 
A 1 173 ASN 173 208 208 ASN ASN F . n 
A 1 174 LYS 174 209 209 LYS LYS F . n 
A 1 175 GLN 175 210 210 GLN GLN F . n 
A 1 176 SER 176 211 211 SER SER F . n 
A 1 177 CYS 177 212 212 CYS CYS F . n 
A 1 178 SER 178 213 213 SER SER F . n 
A 1 179 ILE 179 214 214 ILE ILE F . n 
A 1 180 PRO 180 215 215 PRO PRO F . n 
A 1 181 ASN 181 216 216 ASN ASN F . n 
A 1 182 ILE 182 217 217 ILE ILE F . n 
A 1 183 GLU 183 218 218 GLU GLU F . n 
A 1 184 THR 184 219 219 THR THR F . n 
A 1 185 VAL 185 220 220 VAL VAL F . n 
A 1 186 ILE 186 221 221 ILE ILE F . n 
A 1 187 GLU 187 222 222 GLU GLU F . n 
A 1 188 PHE 188 223 223 PHE PHE F . n 
A 1 189 GLN 189 224 224 GLN GLN F . n 
A 1 190 GLN 190 225 225 GLN GLN F . n 
A 1 191 LYS 191 226 226 LYS LYS F . n 
A 1 192 ASN 192 227 227 ASN ASN F . n 
A 1 193 ASN 193 228 228 ASN ASN F . n 
A 1 194 ARG 194 229 229 ARG ARG F . n 
A 1 195 LEU 195 230 230 LEU LEU F . n 
A 1 196 LEU 196 231 231 LEU LEU F . n 
A 1 197 GLU 197 232 232 GLU GLU F . n 
A 1 198 ILE 198 233 233 ILE ILE F . n 
A 1 199 THR 199 234 234 THR THR F . n 
A 1 200 ARG 200 235 235 ARG ARG F . n 
A 1 201 GLU 201 236 236 GLU GLU F . n 
A 1 202 PHE 202 237 237 PHE PHE F . n 
A 1 203 SER 203 238 238 SER SER F . n 
A 1 204 VAL 204 239 239 VAL VAL F . n 
A 1 205 ASN 205 240 240 ASN ASN F . n 
A 1 206 ALA 206 241 241 ALA ALA F . n 
A 1 207 GLY 207 242 242 GLY GLY F . n 
A 1 208 VAL 208 243 243 VAL VAL F . n 
A 1 209 THR 209 244 244 THR THR F . n 
A 1 210 THR 210 245 245 THR THR F . n 
A 1 211 PRO 211 246 246 PRO PRO F . n 
A 1 212 VAL 212 247 247 VAL VAL F . n 
A 1 213 SER 213 248 248 SER SER F . n 
A 1 214 THR 214 249 249 THR THR F . n 
A 1 215 TYR 215 250 250 TYR TYR F . n 
A 1 216 MET 216 251 251 MET MET F . n 
A 1 217 LEU 217 252 252 LEU LEU F . n 
A 1 218 THR 218 253 253 THR THR F . n 
A 1 219 ASN 219 254 254 ASN ASN F . n 
A 1 220 SER 220 255 255 SER SER F . n 
A 1 221 GLU 221 256 256 GLU GLU F . n 
A 1 222 LEU 222 257 257 LEU LEU F . n 
A 1 223 LEU 223 258 258 LEU LEU F . n 
A 1 224 SER 224 259 259 SER SER F . n 
A 1 225 LEU 225 260 260 LEU LEU F . n 
A 1 226 ILE 226 261 261 ILE ILE F . n 
A 1 227 ASN 227 262 262 ASN ASN F . n 
A 1 228 ASP 228 263 263 ASP ASP F . n 
A 1 229 MET 229 264 264 MET MET F . n 
A 1 230 PRO 230 265 265 PRO PRO F . n 
A 1 231 ILE 231 266 266 ILE ILE F . n 
A 1 232 THR 232 267 267 THR THR F . n 
A 1 233 ASN 233 268 268 ASN ASN F . n 
A 1 234 ASP 234 269 269 ASP ASP F . n 
A 1 235 GLN 235 270 270 GLN GLN F . n 
A 1 236 LYS 236 271 271 LYS LYS F . n 
A 1 237 LYS 237 272 272 LYS LYS F . n 
A 1 238 LEU 238 273 273 LEU LEU F . n 
A 1 239 MET 239 274 274 MET MET F . n 
A 1 240 SER 240 275 275 SER SER F . n 
A 1 241 ASN 241 276 276 ASN ASN F . n 
A 1 242 ASN 242 277 277 ASN ASN F . n 
A 1 243 VAL 243 278 278 VAL VAL F . n 
A 1 244 GLN 244 279 279 GLN GLN F . n 
A 1 245 ILE 245 280 280 ILE ILE F . n 
A 1 246 VAL 246 281 281 VAL VAL F . n 
A 1 247 ARG 247 282 282 ARG ARG F . n 
A 1 248 GLN 248 283 283 GLN GLN F . n 
A 1 249 GLN 249 284 284 GLN GLN F . n 
A 1 250 SER 250 285 285 SER SER F . n 
A 1 251 TYR 251 286 286 TYR TYR F . n 
A 1 252 SER 252 287 287 SER SER F . n 
A 1 253 ILE 253 288 288 ILE ILE F . n 
A 1 254 MET 254 289 289 MET MET F . n 
A 1 255 CYS 255 290 290 CYS CYS F . n 
A 1 256 ILE 256 291 291 ILE ILE F . n 
A 1 257 ILE 257 292 292 ILE ILE F . n 
A 1 258 LYS 258 293 293 LYS LYS F . n 
A 1 259 GLU 259 294 294 GLU GLU F . n 
A 1 260 GLU 260 295 295 GLU GLU F . n 
A 1 261 VAL 261 296 296 VAL VAL F . n 
A 1 262 LEU 262 297 297 LEU LEU F . n 
A 1 263 ALA 263 298 298 ALA ALA F . n 
A 1 264 TYR 264 299 299 TYR TYR F . n 
A 1 265 VAL 265 300 300 VAL VAL F . n 
A 1 266 VAL 266 301 301 VAL VAL F . n 
A 1 267 GLN 267 302 302 GLN GLN F . n 
A 1 268 LEU 268 303 303 LEU LEU F . n 
A 1 269 PRO 269 304 304 PRO PRO F . n 
A 1 270 LEU 270 305 305 LEU LEU F . n 
A 1 271 TYR 271 306 306 TYR TYR F . n 
A 1 272 GLY 272 307 307 GLY GLY F . n 
A 1 273 VAL 273 308 308 VAL VAL F . n 
A 1 274 ILE 274 309 309 ILE ILE F . n 
A 1 275 ASP 275 310 310 ASP ASP F . n 
A 1 276 THR 276 311 311 THR THR F . n 
A 1 277 PRO 277 312 312 PRO PRO F . n 
A 1 278 CYS 278 313 313 CYS CYS F . n 
A 1 279 TRP 279 314 314 TRP TRP F . n 
A 1 280 LYS 280 315 315 LYS LYS F . n 
A 1 281 LEU 281 316 316 LEU LEU F . n 
A 1 282 HIS 282 317 317 HIS HIS F . n 
A 1 283 THR 283 318 318 THR THR F . n 
A 1 284 SER 284 319 319 SER SER F . n 
A 1 285 PRO 285 320 320 PRO PRO F . n 
A 1 286 LEU 286 321 321 LEU LEU F . n 
A 1 287 CYS 287 322 322 CYS CYS F . n 
A 1 288 THR 288 323 323 THR THR F . n 
A 1 289 THR 289 324 324 THR THR F . n 
A 1 290 ASN 290 325 325 ASN ASN F . n 
A 1 291 THR 291 326 326 THR THR F . n 
A 1 292 LYS 292 327 327 LYS LYS F . n 
A 1 293 GLU 293 328 328 GLU GLU F . n 
A 1 294 GLY 294 329 329 GLY GLY F . n 
A 1 295 SER 295 330 330 SER SER F . n 
A 1 296 ASN 296 331 331 ASN ASN F . n 
A 1 297 ILE 297 332 332 ILE ILE F . n 
A 1 298 CYS 298 333 333 CYS CYS F . n 
A 1 299 LEU 299 334 334 LEU LEU F . n 
A 1 300 THR 300 335 335 THR THR F . n 
A 1 301 ARG 301 336 336 ARG ARG F . n 
A 1 302 THR 302 337 337 THR THR F . n 
A 1 303 ASP 303 338 338 ASP ASP F . n 
A 1 304 ARG 304 339 339 ARG ARG F . n 
A 1 305 GLY 305 340 340 GLY GLY F . n 
A 1 306 TRP 306 341 341 TRP TRP F . n 
A 1 307 TYR 307 342 342 TYR TYR F . n 
A 1 308 CYS 308 343 343 CYS CYS F . n 
A 1 309 ASP 309 344 344 ASP ASP F . n 
A 1 310 ASN 310 345 345 ASN ASN F . n 
A 1 311 ALA 311 346 346 ALA ALA F . n 
A 1 312 GLY 312 347 347 GLY GLY F . n 
A 1 313 SER 313 348 348 SER SER F . n 
A 1 314 VAL 314 349 349 VAL VAL F . n 
A 1 315 SER 315 350 350 SER SER F . n 
A 1 316 PHE 316 351 351 PHE PHE F . n 
A 1 317 PHE 317 352 352 PHE PHE F . n 
A 1 318 PRO 318 353 353 PRO PRO F . n 
A 1 319 GLN 319 354 354 GLN GLN F . n 
A 1 320 ALA 320 355 355 ALA ALA F . n 
A 1 321 GLU 321 356 356 GLU GLU F . n 
A 1 322 THR 322 357 357 THR THR F . n 
A 1 323 CYS 323 358 358 CYS CYS F . n 
A 1 324 LYS 324 359 359 LYS LYS F . n 
A 1 325 VAL 325 360 360 VAL VAL F . n 
A 1 326 GLN 326 361 361 GLN GLN F . n 
A 1 327 SER 327 362 362 SER SER F . n 
A 1 328 ASN 328 363 363 ASN ASN F . n 
A 1 329 ARG 329 364 364 ARG ARG F . n 
A 1 330 VAL 330 365 365 VAL VAL F . n 
A 1 331 PHE 331 366 366 PHE PHE F . n 
A 1 332 CYS 332 367 367 CYS CYS F . n 
A 1 333 ASP 333 368 368 ASP ASP F . n 
A 1 334 THR 334 369 369 THR THR F . n 
A 1 335 MET 335 370 370 MET MET F . n 
A 1 336 ASN 336 371 371 ASN ASN F . n 
A 1 337 SER 337 372 372 SER SER F . n 
A 1 338 LEU 338 373 373 LEU LEU F . n 
A 1 339 THR 339 374 374 THR THR F . n 
A 1 340 LEU 340 375 375 LEU LEU F . n 
A 1 341 PRO 341 376 376 PRO PRO F . n 
A 1 342 SER 342 377 377 SER SER F . n 
A 1 343 GLU 343 378 378 GLU GLU F . n 
A 1 344 VAL 344 379 379 VAL VAL F . n 
A 1 345 ASN 345 380 380 ASN ASN F . n 
A 1 346 LEU 346 381 381 LEU LEU F . n 
A 1 347 CYS 347 382 382 CYS CYS F . n 
A 1 348 ASN 348 383 383 ASN ASN F . n 
A 1 349 VAL 349 384 384 VAL VAL F . n 
A 1 350 ASP 350 385 385 ASP ASP F . n 
A 1 351 ILE 351 386 386 ILE ILE F . n 
A 1 352 PHE 352 387 387 PHE PHE F . n 
A 1 353 ASN 353 388 388 ASN ASN F . n 
A 1 354 PRO 354 389 389 PRO PRO F . n 
A 1 355 LYS 355 390 390 LYS LYS F . n 
A 1 356 TYR 356 391 391 TYR TYR F . n 
A 1 357 ASP 357 392 392 ASP ASP F . n 
A 1 358 CYS 358 393 393 CYS CYS F . n 
A 1 359 LYS 359 394 394 LYS LYS F . n 
A 1 360 ILE 360 395 395 ILE ILE F . n 
A 1 361 MET 361 396 396 MET MET F . n 
A 1 362 THR 362 397 397 THR THR F . n 
A 1 363 SER 363 398 398 SER SER F . n 
A 1 364 LYS 364 399 399 LYS LYS F . n 
A 1 365 THR 365 400 400 THR THR F . n 
A 1 366 ASP 366 401 401 ASP ASP F . n 
A 1 367 VAL 367 402 402 VAL VAL F . n 
A 1 368 SER 368 403 403 SER SER F . n 
A 1 369 SER 369 404 404 SER SER F . n 
A 1 370 SER 370 405 405 SER SER F . n 
A 1 371 VAL 371 406 406 VAL VAL F . n 
A 1 372 ILE 372 407 407 ILE ILE F . n 
A 1 373 THR 373 408 408 THR THR F . n 
A 1 374 SER 374 409 409 SER SER F . n 
A 1 375 LEU 375 410 410 LEU LEU F . n 
A 1 376 GLY 376 411 411 GLY GLY F . n 
A 1 377 ALA 377 412 412 ALA ALA F . n 
A 1 378 ILE 378 413 413 ILE ILE F . n 
A 1 379 VAL 379 414 414 VAL VAL F . n 
A 1 380 SER 380 415 415 SER SER F . n 
A 1 381 CYS 381 416 416 CYS CYS F . n 
A 1 382 TYR 382 417 417 TYR TYR F . n 
A 1 383 GLY 383 418 418 GLY GLY F . n 
A 1 384 LYS 384 419 419 LYS LYS F . n 
A 1 385 THR 385 420 420 THR THR F . n 
A 1 386 LYS 386 421 421 LYS LYS F . n 
A 1 387 CYS 387 422 422 CYS CYS F . n 
A 1 388 THR 388 423 423 THR THR F . n 
A 1 389 ALA 389 424 424 ALA ALA F . n 
A 1 390 SER 390 425 425 SER SER F . n 
A 1 391 ASN 391 426 426 ASN ASN F . n 
A 1 392 LYS 392 427 427 LYS LYS F . n 
A 1 393 ASN 393 428 428 ASN ASN F . n 
A 1 394 ARG 394 429 429 ARG ARG F . n 
A 1 395 GLY 395 430 430 GLY GLY F . n 
A 1 396 ILE 396 431 431 ILE ILE F . n 
A 1 397 ILE 397 432 432 ILE ILE F . n 
A 1 398 LYS 398 433 433 LYS LYS F . n 
A 1 399 THR 399 434 434 THR THR F . n 
A 1 400 PHE 400 435 435 PHE PHE F . n 
A 1 401 SER 401 436 436 SER SER F . n 
A 1 402 ASN 402 437 437 ASN ASN F . n 
A 1 403 GLY 403 438 438 GLY GLY F . n 
A 1 404 CYS 404 439 439 CYS CYS F . n 
A 1 405 ASP 405 440 440 ASP ASP F . n 
A 1 406 TYR 406 441 441 TYR TYR F . n 
A 1 407 VAL 407 442 442 VAL VAL F . n 
A 1 408 SER 408 443 443 SER SER F . n 
A 1 409 ASN 409 444 444 ASN ASN F . n 
A 1 410 LYS 410 445 445 LYS LYS F . n 
A 1 411 GLY 411 446 446 GLY GLY F . n 
A 1 412 VAL 412 447 447 VAL VAL F . n 
A 1 413 ASP 413 448 448 ASP ASP F . n 
A 1 414 THR 414 449 449 THR THR F . n 
A 1 415 VAL 415 450 450 VAL VAL F . n 
A 1 416 SER 416 451 451 SER SER F . n 
A 1 417 VAL 417 452 452 VAL VAL F . n 
A 1 418 GLY 418 453 453 GLY GLY F . n 
A 1 419 ASN 419 454 454 ASN ASN F . n 
A 1 420 THR 420 455 455 THR THR F . n 
A 1 421 LEU 421 456 456 LEU LEU F . n 
A 1 422 TYR 422 457 457 TYR TYR F . n 
A 1 423 CYS 423 458 458 CYS CYS F . n 
A 1 424 VAL 424 459 459 VAL VAL F . n 
A 1 425 ASN 425 460 460 ASN ASN F . n 
A 1 426 LYS 426 461 461 LYS LYS F . n 
A 1 427 GLN 427 462 462 GLN GLN F . n 
A 1 428 GLU 428 463 463 GLU GLU F . n 
A 1 429 GLY 429 464 464 GLY GLY F . n 
A 1 430 GLN 430 465 465 GLN GLN F . n 
A 1 431 SER 431 466 466 SER SER F . n 
A 1 432 LEU 432 467 467 LEU LEU F . n 
A 1 433 TYR 433 468 468 TYR TYR F . n 
A 1 434 VAL 434 469 469 VAL VAL F . n 
A 1 435 LYS 435 470 470 LYS LYS F . n 
A 1 436 GLY 436 471 471 GLY GLY F . n 
A 1 437 GLU 437 472 472 GLU GLU F . n 
A 1 438 PRO 438 473 473 PRO PRO F . n 
A 1 439 ILE 439 474 474 ILE ILE F . n 
A 1 440 ILE 440 475 475 ILE ILE F . n 
A 1 441 ASN 441 476 476 ASN ASN F . n 
A 1 442 PHE 442 477 477 PHE PHE F . n 
A 1 443 TYR 443 478 478 TYR TYR F . n 
A 1 444 ASP 444 479 479 ASP ASP F . n 
A 1 445 PRO 445 480 480 PRO PRO F . n 
A 1 446 LEU 446 481 481 LEU LEU F . n 
A 1 447 VAL 447 482 482 VAL VAL F . n 
A 1 448 PHE 448 483 483 PHE PHE F . n 
A 1 449 PRO 449 484 484 PRO PRO F . n 
A 1 450 SER 450 485 485 SER SER F . n 
A 1 451 ASN 451 486 486 ASN ASN F . n 
A 1 452 GLN 452 487 487 GLN GLN F . n 
A 1 453 PHE 453 488 488 PHE PHE F . n 
A 1 454 ASP 454 489 489 ASP ASP F . n 
A 1 455 ALA 455 490 490 ALA ALA F . n 
A 1 456 SER 456 491 491 SER SER F . n 
A 1 457 ILE 457 492 492 ILE ILE F . n 
A 1 458 SER 458 493 493 SER SER F . n 
A 1 459 GLN 459 494 494 GLN GLN F . n 
A 1 460 VAL 460 495 495 VAL VAL F . n 
A 1 461 ASN 461 496 496 ASN ASN F . n 
A 1 462 GLU 462 497 497 GLU GLU F . n 
A 1 463 LYS 463 498 498 LYS LYS F . n 
A 1 464 ILE 464 499 499 ILE ILE F . n 
A 1 465 ASN 465 500 500 ASN ASN F . n 
A 1 466 GLN 466 501 501 GLN GLN F . n 
A 1 467 SER 467 502 502 SER SER F . n 
A 1 468 LEU 468 503 503 LEU LEU F . n 
A 1 469 ALA 469 504 504 ALA ALA F . n 
A 1 470 PHE 470 505 505 PHE PHE F . n 
A 1 471 ILE 471 506 506 ILE ILE F . n 
A 1 472 ARG 472 507 507 ARG ARG F . n 
A 1 473 LYS 473 508 508 LYS LYS F . n 
A 1 474 SER 474 509 509 SER SER F . n 
A 1 475 ASP 475 510 510 ASP ASP F . n 
A 1 476 GLU 476 511 511 GLU GLU F . n 
A 1 477 LEU 477 512 ?   ?   ?   F . n 
A 1 478 LEU 478 513 ?   ?   ?   F . n 
A 1 479 ALA 479 514 ?   ?   ?   F . n 
A 1 480 SER 480 515 ?   ?   ?   F . n 
A 1 481 GLY 481 516 ?   ?   ?   F . n 
A 1 482 TYR 482 517 ?   ?   ?   F . n 
A 1 483 ILE 483 518 ?   ?   ?   F . n 
A 1 484 PRO 484 519 ?   ?   ?   F . n 
A 1 485 GLU 485 520 ?   ?   ?   F . n 
A 1 486 ALA 486 521 ?   ?   ?   F . n 
A 1 487 PRO 487 522 ?   ?   ?   F . n 
A 1 488 ARG 488 523 ?   ?   ?   F . n 
A 1 489 ASP 489 524 ?   ?   ?   F . n 
A 1 490 GLY 490 525 ?   ?   ?   F . n 
A 1 491 GLN 491 526 ?   ?   ?   F . n 
A 1 492 ALA 492 527 ?   ?   ?   F . n 
A 1 493 TYR 493 528 ?   ?   ?   F . n 
A 1 494 VAL 494 529 ?   ?   ?   F . n 
A 1 495 ARG 495 530 ?   ?   ?   F . n 
A 1 496 LYS 496 531 ?   ?   ?   F . n 
A 1 497 ASP 497 532 ?   ?   ?   F . n 
A 1 498 GLY 498 533 ?   ?   ?   F . n 
A 1 499 GLU 499 534 ?   ?   ?   F . n 
A 1 500 TRP 500 535 ?   ?   ?   F . n 
A 1 501 VAL 501 536 ?   ?   ?   F . n 
A 1 502 LEU 502 537 ?   ?   ?   F . n 
A 1 503 LEU 503 538 ?   ?   ?   F . n 
A 1 504 SER 504 539 ?   ?   ?   F . n 
A 1 505 THR 505 540 ?   ?   ?   F . n 
A 1 506 PHE 506 541 ?   ?   ?   F . n 
A 1 507 LEU 507 542 ?   ?   ?   F . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 EDO 1  601 540 EDO EDO F . 
C 2 EDO 1  602 541 EDO EDO F . 
D 2 EDO 1  603 542 EDO EDO F . 
E 3 NAG 1  604 543 NAG NAG F . 
F 4 HOH 1  701 27  HOH HOH F . 
F 4 HOH 2  702 41  HOH HOH F . 
F 4 HOH 3  703 21  HOH HOH F . 
F 4 HOH 4  704 73  HOH HOH F . 
F 4 HOH 5  705 25  HOH HOH F . 
F 4 HOH 6  706 34  HOH HOH F . 
F 4 HOH 7  707 44  HOH HOH F . 
F 4 HOH 8  708 31  HOH HOH F . 
F 4 HOH 9  709 32  HOH HOH F . 
F 4 HOH 10 710 22  HOH HOH F . 
F 4 HOH 11 711 55  HOH HOH F . 
F 4 HOH 12 712 74  HOH HOH F . 
F 4 HOH 13 713 35  HOH HOH F . 
F 4 HOH 14 714 64  HOH HOH F . 
F 4 HOH 15 715 9   HOH HOH F . 
F 4 HOH 16 716 46  HOH HOH F . 
F 4 HOH 17 717 26  HOH HOH F . 
F 4 HOH 18 718 23  HOH HOH F . 
F 4 HOH 19 719 10  HOH HOH F . 
F 4 HOH 20 720 11  HOH HOH F . 
F 4 HOH 21 721 60  HOH HOH F . 
F 4 HOH 22 722 1   HOH HOH F . 
F 4 HOH 23 723 30  HOH HOH F . 
F 4 HOH 24 724 42  HOH HOH F . 
F 4 HOH 25 725 75  HOH HOH F . 
F 4 HOH 26 726 37  HOH HOH F . 
F 4 HOH 27 727 45  HOH HOH F . 
F 4 HOH 28 728 15  HOH HOH F . 
F 4 HOH 29 729 66  HOH HOH F . 
F 4 HOH 30 730 5   HOH HOH F . 
F 4 HOH 31 731 13  HOH HOH F . 
F 4 HOH 32 732 3   HOH HOH F . 
F 4 HOH 33 733 77  HOH HOH F . 
F 4 HOH 34 734 70  HOH HOH F . 
F 4 HOH 35 735 48  HOH HOH F . 
F 4 HOH 36 736 53  HOH HOH F . 
F 4 HOH 37 737 61  HOH HOH F . 
F 4 HOH 38 738 71  HOH HOH F . 
F 4 HOH 39 739 29  HOH HOH F . 
F 4 HOH 40 740 72  HOH HOH F . 
F 4 HOH 41 741 36  HOH HOH F . 
F 4 HOH 42 742 58  HOH HOH F . 
F 4 HOH 43 743 17  HOH HOH F . 
F 4 HOH 44 744 24  HOH HOH F . 
F 4 HOH 45 745 20  HOH HOH F . 
F 4 HOH 46 746 67  HOH HOH F . 
F 4 HOH 47 747 16  HOH HOH F . 
F 4 HOH 48 748 62  HOH HOH F . 
F 4 HOH 49 749 14  HOH HOH F . 
F 4 HOH 50 750 47  HOH HOH F . 
F 4 HOH 51 751 54  HOH HOH F . 
F 4 HOH 52 752 33  HOH HOH F . 
F 4 HOH 53 753 76  HOH HOH F . 
F 4 HOH 54 754 56  HOH HOH F . 
F 4 HOH 55 755 7   HOH HOH F . 
F 4 HOH 56 756 8   HOH HOH F . 
F 4 HOH 57 757 43  HOH HOH F . 
F 4 HOH 58 758 50  HOH HOH F . 
F 4 HOH 59 759 63  HOH HOH F . 
F 4 HOH 60 760 12  HOH HOH F . 
F 4 HOH 61 761 2   HOH HOH F . 
F 4 HOH 62 762 52  HOH HOH F . 
F 4 HOH 63 763 38  HOH HOH F . 
F 4 HOH 64 764 6   HOH HOH F . 
F 4 HOH 65 765 18  HOH HOH F . 
F 4 HOH 66 766 69  HOH HOH F . 
F 4 HOH 67 767 68  HOH HOH F . 
F 4 HOH 68 768 39  HOH HOH F . 
F 4 HOH 69 769 59  HOH HOH F . 
F 4 HOH 70 770 19  HOH HOH F . 
F 4 HOH 71 771 51  HOH HOH F . 
F 4 HOH 72 772 4   HOH HOH F . 
F 4 HOH 73 773 65  HOH HOH F . 
F 4 HOH 74 774 28  HOH HOH F . 
F 4 HOH 75 775 79  HOH HOH F . 
F 4 HOH 76 776 49  HOH HOH F . 
F 4 HOH 77 777 57  HOH HOH F . 
F 4 HOH 78 778 78  HOH HOH F . 
F 4 HOH 79 779 40  HOH HOH F . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W3L 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     168.482 
_cell.length_a_esd                 ? 
_cell.length_b                     168.482 
_cell.length_b_esd                 ? 
_cell.length_c                     168.482 
_cell.length_c_esd                 ? 
_cell.volume                       4782561.107 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W3L 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                213 
_symmetry.space_group_name_Hall            'P 4bd 2ab 3' 
_symmetry.space_group_name_H-M             'P 41 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8W3L 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.58 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          65.65 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M tri-Potassium citrate, 20% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-11-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          52.84 
_reflns.entry_id                                       8W3L 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.3 
_reflns.d_resolution_low                               48.64 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     36757 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.77 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                69.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          29.43 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.3 
_reflns_shell.d_res_low                                     2.383 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3545 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  1 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               66.78 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8W3L 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.30 
_refine.ls_d_res_low                             48.64 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     36740 
_refine.ls_number_reflns_R_free                  1799 
_refine.ls_number_reflns_R_work                  34941 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.79 
_refine.ls_percent_reflns_R_free                 4.90 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2286 
_refine.ls_R_factor_R_free                       0.2565 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2272 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 29.0614 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3217 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.30 
_refine_hist.d_res_low                        48.64 
_refine_hist.number_atoms_solvent             79 
_refine_hist.number_atoms_total               3548 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3443 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         26 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0097 ? 3522 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.4179 ? 4772 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0744 ? 577  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0143 ? 604  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 4.2548 ? 482  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.30 2.36  . . 154 2544 98.07  . . . . 0.3368 . . . . . . . . . . . 0.3884 
'X-RAY DIFFRACTION' 2.36 2.43  . . 125 2663 99.68  . . . . 0.3204 . . . . . . . . . . . 0.3392 
'X-RAY DIFFRACTION' 2.43 2.51  . . 130 2640 100.00 . . . . 0.3043 . . . . . . . . . . . 0.3340 
'X-RAY DIFFRACTION' 2.51 2.60  . . 133 2648 100.00 . . . . 0.2880 . . . . . . . . . . . 0.3287 
'X-RAY DIFFRACTION' 2.60 2.70  . . 110 2683 100.00 . . . . 0.2677 . . . . . . . . . . . 0.3243 
'X-RAY DIFFRACTION' 2.70 2.83  . . 131 2648 99.96  . . . . 0.2754 . . . . . . . . . . . 0.2961 
'X-RAY DIFFRACTION' 2.83 2.98  . . 147 2668 100.00 . . . . 0.2730 . . . . . . . . . . . 0.3341 
'X-RAY DIFFRACTION' 2.98 3.16  . . 135 2658 100.00 . . . . 0.2594 . . . . . . . . . . . 0.2831 
'X-RAY DIFFRACTION' 3.16 3.41  . . 144 2685 100.00 . . . . 0.2637 . . . . . . . . . . . 0.2790 
'X-RAY DIFFRACTION' 3.41 3.75  . . 132 2720 100.00 . . . . 0.2302 . . . . . . . . . . . 0.2900 
'X-RAY DIFFRACTION' 3.75 4.29  . . 152 2703 100.00 . . . . 0.2098 . . . . . . . . . . . 0.2446 
'X-RAY DIFFRACTION' 4.29 5.40  . . 146 2755 100.00 . . . . 0.1790 . . . . . . . . . . . 0.2083 
'X-RAY DIFFRACTION' 5.41 48.64 . . 160 2926 99.68  . . . . 0.1929 . . . . . . . . . . . 0.2046 
# 
_struct.entry_id                     8W3L 
_struct.title                        'Crystal structure of prefusion-stabilized RSV F protein UFCR2-iSS-P2-NQ' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W3L 
_struct_keywords.text            'Respiratory syncytial virus, glycoprotein, prefusion vaccine, stabilized, viral protein' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8W3L 
_struct_ref.pdbx_db_accession          8W3L 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8W3L 
_struct_ref_seq.pdbx_strand_id                F 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 507 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8W3L 
_struct_ref_seq.db_align_beg                  -3 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  542 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -3 
_struct_ref_seq.pdbx_auth_seq_align_end       542 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 10940 ? 
1 MORE         -5    ? 
1 'SSA (A^2)'  56480 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000 0.0000000000 0.0000000000 0.0000000000    0.0000000000 1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000    
2 'crystal symmetry operation' 5_663 z+1,x+1,y-2 0.0000000000 0.0000000000 1.0000000000 168.4820000000  1.0000000000 0.0000000000 
0.0000000000 168.4820000000 0.0000000000 1.0000000000 0.0000000000 -336.9640000000 
3 'crystal symmetry operation' 9_474 y-1,z+2,x-1 0.0000000000 1.0000000000 0.0000000000 -168.4820000000 0.0000000000 0.0000000000 
1.0000000000 336.9640000000 1.0000000000 0.0000000000 0.0000000000 -168.4820000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 77  ? SER A 103 ? ASP F 73  SER F 99  1 ? 27 
HELX_P HELX_P2  AA2 SER A 109 ? ALA A 112 ? SER F 144 ALA F 147 5 ? 4  
HELX_P HELX_P3  AA3 ILE A 113 ? HIS A 124 ? ILE F 148 HIS F 159 1 ? 12 
HELX_P HELX_P4  AA4 GLY A 127 ? LEU A 136 ? GLY F 162 LEU F 171 1 ? 10 
HELX_P HELX_P5  AA5 LEU A 160 ? LEU A 168 ? LEU F 195 LEU F 203 1 ? 9  
HELX_P HELX_P6  AA6 LEU A 168 ? ASN A 173 ? LEU F 203 ASN F 208 1 ? 6  
HELX_P HELX_P7  AA7 ASN A 181 ? ASN A 205 ? ASN F 216 ASN F 240 1 ? 25 
HELX_P HELX_P8  AA8 THR A 218 ? ASP A 228 ? THR F 253 ASP F 263 1 ? 11 
HELX_P HELX_P9  AA9 THR A 232 ? ASN A 242 ? THR F 267 ASN F 277 1 ? 11 
HELX_P HELX_P10 AB1 ASN A 242 ? GLN A 249 ? ASN F 277 GLN F 284 1 ? 8  
HELX_P HELX_P11 AB2 GLN A 319 ? GLU A 321 ? GLN F 354 GLU F 356 5 ? 3  
HELX_P HELX_P12 AB3 MET A 335 ? SER A 337 ? MET F 370 SER F 372 5 ? 3  
HELX_P HELX_P13 AB4 PRO A 341 ? VAL A 349 ? PRO F 376 VAL F 384 5 ? 9  
HELX_P HELX_P14 AB5 PRO A 438 ? TYR A 443 ? PRO F 473 TYR F 478 5 ? 6  
HELX_P HELX_P15 AB6 ASP A 444 ? PHE A 448 ? ASP F 479 PHE F 483 5 ? 5  
HELX_P HELX_P16 AB7 ILE A 457 ? LYS A 473 ? ILE F 492 LYS F 508 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 41  SG  ? ? ? 1_555 A CYS 404 SG ? ? F CYS 37  F CYS 439 1_555 ? ? ? ? ? ? ? 2.023 ? ?               
disulf2 disulf ?   ? A CYS 73  SG  ? ? ? 1_555 A CYS 177 SG ? ? F CYS 69  F CYS 212 1_555 ? ? ? ? ? ? ? 2.057 ? ?               
disulf3 disulf ?   ? A CYS 114 SG  ? ? ? 1_555 A CYS 423 SG ? ? F CYS 149 F CYS 458 5_663 ? ? ? ? ? ? ? 2.092 ? ?               
disulf4 disulf ?   ? A CYS 120 SG  ? ? ? 1_555 A CYS 255 SG ? ? F CYS 155 F CYS 290 1_555 ? ? ? ? ? ? ? 2.068 ? ?               
disulf5 disulf ?   ? A CYS 278 SG  ? ? ? 1_555 A CYS 308 SG ? ? F CYS 313 F CYS 343 1_555 ? ? ? ? ? ? ? 2.036 ? ?               
disulf6 disulf ?   ? A CYS 287 SG  ? ? ? 1_555 A CYS 298 SG ? ? F CYS 322 F CYS 333 1_555 ? ? ? ? ? ? ? 2.065 ? ?               
disulf7 disulf ?   ? A CYS 323 SG  ? ? ? 1_555 A CYS 332 SG ? ? F CYS 358 F CYS 367 1_555 ? ? ? ? ? ? ? 2.071 ? ?               
disulf8 disulf ?   ? A CYS 347 SG  ? ? ? 1_555 A CYS 358 SG ? ? F CYS 382 F CYS 393 1_555 ? ? ? ? ? ? ? 2.074 ? ?               
disulf9 disulf ?   ? A CYS 381 SG  ? ? ? 1_555 A CYS 387 SG ? ? F CYS 416 F CYS 422 1_555 ? ? ? ? ? ? ? 2.116 ? ?               
covale1 covale one ? A ASN 465 ND2 ? ? ? 1_555 E NAG .   C1 ? ? F ASN 500 F NAG 604 1_555 ? ? ? ? ? ? ? 1.449 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG E .   ? ASN A 465 ? NAG F 604 ? 1_555 ASN F 500 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  CYS A 41  ? CYS A 404 ? CYS F 37  ? 1_555 CYS F 439 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3  CYS A 73  ? CYS A 177 ? CYS F 69  ? 1_555 CYS F 212 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4  CYS A 114 ? CYS A 423 ? CYS F 149 ? 1_555 CYS F 458 ? 5_663 SG SG  .   . .   None            'Disulfide bridge' 
5  CYS A 120 ? CYS A 255 ? CYS F 155 ? 1_555 CYS F 290 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6  CYS A 278 ? CYS A 308 ? CYS F 313 ? 1_555 CYS F 343 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7  CYS A 287 ? CYS A 298 ? CYS F 322 ? 1_555 CYS F 333 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS A 323 ? CYS A 332 ? CYS F 358 ? 1_555 CYS F 367 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS A 347 ? CYS A 358 ? CYS F 382 ? 1_555 CYS F 393 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS A 381 ? CYS A 387 ? CYS F 416 ? 1_555 CYS F 422 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          THR 
_struct_mon_prot_cis.label_seq_id           210 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           THR 
_struct_mon_prot_cis.auth_seq_id            245 
_struct_mon_prot_cis.auth_asym_id           F 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    211 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     246 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    F 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.52 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 6 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? parallel      
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA1 2 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA1 3 SER A 42  ? ARG A 53  ? SER F 38  ARG F 49  
AA1 4 VAL A 273 ? THR A 283 ? VAL F 308 THR F 318 
AA1 5 GLY A 305 ? ASN A 310 ? GLY F 340 ASN F 345 
AA1 6 SER A 313 ? PHE A 317 ? SER F 348 PHE F 352 
AA1 7 LEU A 338 ? LEU A 340 ? LEU F 373 LEU F 375 
AA2 1 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA2 2 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA2 3 SER A 42  ? ARG A 53  ? SER F 38  ARG F 49  
AA2 4 THR A 33  ? TYR A 37  ? THR F 29  TYR F 33  
AA2 5 GLN A 430 ? VAL A 434 ? GLN F 465 VAL F 469 
AA3 1 ALA A 142 ? SER A 145 ? ALA F 177 SER F 180 
AA3 2 SER A 151 ? ASP A 159 ? SER F 186 ASP F 194 
AA3 3 GLY A 55  ? GLU A 64  ? GLY F 51  GLU F 60  
AA3 4 VAL A 261 ? LEU A 270 ? VAL F 296 LEU F 305 
AA3 5 TYR A 251 ? ILE A 257 ? TYR F 286 ILE F 292 
AA3 6 VAL A 208 ? THR A 209 ? VAL F 243 THR F 244 
AA4 1 LEU A 286 ? CYS A 287 ? LEU F 321 CYS F 322 
AA4 2 CYS A 298 ? ARG A 301 ? CYS F 333 ARG F 336 
AA4 3 LYS A 359 ? SER A 363 ? LYS F 394 SER F 398 
AA4 4 ALA A 455 ? SER A 456 ? ALA F 490 SER F 491 
AA5 1 SER A 369 ? ILE A 372 ? SER F 404 ILE F 407 
AA5 2 GLY A 376 ? CYS A 381 ? GLY F 411 CYS F 416 
AA5 3 GLY A 403 ? SER A 408 ? GLY F 438 SER F 443 
AA6 1 GLY A 395 ? THR A 399 ? GLY F 430 THR F 434 
AA6 2 CYS A 387 ? ASN A 391 ? CYS F 422 ASN F 426 
AA6 3 THR A 414 ? VAL A 417 ? THR F 449 VAL F 452 
AA6 4 THR A 420 ? CYS A 423 ? THR F 455 CYS F 458 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 326 ? N GLN F 361 O ARG A 329 ? O ARG F 364 
AA1 2 3 O VAL A 330 ? O VAL F 365 N ALA A 51  ? N ALA F 47  
AA1 3 4 N GLY A 50  ? N GLY F 46  O THR A 276 ? O THR F 311 
AA1 4 5 N TRP A 279 ? N TRP F 314 O TYR A 307 ? O TYR F 342 
AA1 5 6 N CYS A 308 ? N CYS F 343 O SER A 315 ? O SER F 350 
AA1 6 7 N VAL A 314 ? N VAL F 349 O LEU A 340 ? O LEU F 375 
AA2 1 2 N GLN A 326 ? N GLN F 361 O ARG A 329 ? O ARG F 364 
AA2 2 3 O VAL A 330 ? O VAL F 365 N ALA A 51  ? N ALA F 47  
AA2 3 4 O SER A 42  ? O SER F 38  N TYR A 37  ? N TYR F 33  
AA2 4 5 N PHE A 36  ? N PHE F 32  O VAL A 434 ? O VAL F 469 
AA3 1 2 N VAL A 144 ? N VAL F 179 O VAL A 152 ? O VAL F 187 
AA3 2 3 O SER A 155 ? O SER F 190 N VAL A 60  ? N VAL F 56  
AA3 3 4 N ILE A 61  ? N ILE F 57  O TYR A 264 ? O TYR F 299 
AA3 4 5 O VAL A 265 ? O VAL F 300 N ILE A 253 ? N ILE F 288 
AA3 5 6 O SER A 252 ? O SER F 287 N THR A 209 ? N THR F 244 
AA4 1 2 N LEU A 286 ? N LEU F 321 O LEU A 299 ? O LEU F 334 
AA4 2 3 N CYS A 298 ? N CYS F 333 O SER A 363 ? O SER F 398 
AA4 3 4 N ILE A 360 ? N ILE F 395 O ALA A 455 ? O ALA F 490 
AA5 1 2 N SER A 369 ? N SER F 404 O SER A 380 ? O SER F 415 
AA5 2 3 N VAL A 379 ? N VAL F 414 O ASP A 405 ? O ASP F 440 
AA6 1 2 O ILE A 397 ? O ILE F 432 N ALA A 389 ? N ALA F 424 
AA6 2 3 N THR A 388 ? N THR F 423 O SER A 416 ? O SER F 451 
AA6 3 4 N VAL A 415 ? N VAL F 450 O TYR A 422 ? O TYR F 457 
# 
_pdbx_entry_details.entry_id                   8W3L 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS F 68  ? ? -31.55  127.78  
2  1 ASN F 70  ? ? -56.05  107.72  
3  1 THR F 72  ? ? -142.12 -52.85  
4  1 LEU F 171 ? ? -93.24  34.29   
5  1 ASN F 208 ? ? -106.63 59.85   
6  1 CYS F 290 ? ? -95.20  -101.80 
7  1 SER F 362 ? ? 40.70   -117.65 
8  1 ASN F 371 ? ? -116.70 64.81   
9  1 PHE F 488 ? ? -112.65 -73.26  
10 1 ASP F 489 ? ? -104.17 57.50   
11 1 ASP F 510 ? ? -130.06 -39.63  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  x+1/4,-z+1/4,y+3/4   
3  x+3/4,z+1/4,-y+1/4   
4  z+3/4,y+1/4,-x+1/4   
5  -z+1/4,y+3/4,x+1/4   
6  -y+1/4,x+3/4,z+1/4   
7  y+1/4,-x+1/4,z+3/4   
8  z,x,y                
9  y,z,x                
10 -y+1/2,-z,x+1/2      
11 z+1/2,-x+1/2,-y      
12 -y,z+1/2,-x+1/2      
13 -z+1/2,-x,y+1/2      
14 -z,x+1/2,-y+1/2      
15 y+1/2,-z+1/2,-x      
16 x+1/2,-y+1/2,-z      
17 -x,y+1/2,-z+1/2      
18 -x+1/2,-y,z+1/2      
19 y+3/4,x+1/4,-z+1/4   
20 -y+3/4,-x+3/4,-z+3/4 
21 z+1/4,-y+1/4,x+3/4   
22 -z+3/4,-y+3/4,-x+3/4 
23 -x+1/4,z+3/4,y+1/4   
24 -x+3/4,-z+3/4,-y+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 F MET -3  ? A MET 1   
2  1 Y 1 F GLY -2  ? A GLY 2   
3  1 Y 1 F ILE -1  ? A ILE 3   
4  1 Y 1 F LEU 0   ? A LEU 4   
5  1 Y 1 F PRO 1   ? A PRO 5   
6  1 Y 1 F SER 2   ? A SER 6   
7  1 Y 1 F PRO 3   ? A PRO 7   
8  1 Y 1 F GLY 4   ? A GLY 8   
9  1 Y 1 F MET 5   ? A MET 9   
10 1 Y 1 F PRO 6   ? A PRO 10  
11 1 Y 1 F ALA 7   ? A ALA 11  
12 1 Y 1 F LEU 8   ? A LEU 12  
13 1 Y 1 F LEU 9   ? A LEU 13  
14 1 Y 1 F SER 10  ? A SER 14  
15 1 Y 1 F LEU 11  ? A LEU 15  
16 1 Y 1 F VAL 12  ? A VAL 16  
17 1 Y 1 F SER 13  ? A SER 17  
18 1 Y 1 F LEU 14  ? A LEU 18  
19 1 Y 1 F LEU 15  ? A LEU 19  
20 1 Y 1 F SER 16  ? A SER 20  
21 1 Y 1 F VAL 17  ? A VAL 21  
22 1 Y 1 F LEU 18  ? A LEU 22  
23 1 Y 1 F LEU 19  ? A LEU 23  
24 1 Y 1 F MET 20  ? A MET 24  
25 1 Y 1 F GLY 21  ? A GLY 25  
26 1 Y 1 F CYS 22  ? A CYS 26  
27 1 Y 1 F VAL 23  ? A VAL 27  
28 1 Y 1 F ALA 24  ? A ALA 28  
29 1 Y 1 F GLU 25  ? A GLU 29  
30 1 Y 1 F LEU 512 ? A LEU 477 
31 1 Y 1 F LEU 513 ? A LEU 478 
32 1 Y 1 F ALA 514 ? A ALA 479 
33 1 Y 1 F SER 515 ? A SER 480 
34 1 Y 1 F GLY 516 ? A GLY 481 
35 1 Y 1 F TYR 517 ? A TYR 482 
36 1 Y 1 F ILE 518 ? A ILE 483 
37 1 Y 1 F PRO 519 ? A PRO 484 
38 1 Y 1 F GLU 520 ? A GLU 485 
39 1 Y 1 F ALA 521 ? A ALA 486 
40 1 Y 1 F PRO 522 ? A PRO 487 
41 1 Y 1 F ARG 523 ? A ARG 488 
42 1 Y 1 F ASP 524 ? A ASP 489 
43 1 Y 1 F GLY 525 ? A GLY 490 
44 1 Y 1 F GLN 526 ? A GLN 491 
45 1 Y 1 F ALA 527 ? A ALA 492 
46 1 Y 1 F TYR 528 ? A TYR 493 
47 1 Y 1 F VAL 529 ? A VAL 494 
48 1 Y 1 F ARG 530 ? A ARG 495 
49 1 Y 1 F LYS 531 ? A LYS 496 
50 1 Y 1 F ASP 532 ? A ASP 497 
51 1 Y 1 F GLY 533 ? A GLY 498 
52 1 Y 1 F GLU 534 ? A GLU 499 
53 1 Y 1 F TRP 535 ? A TRP 500 
54 1 Y 1 F VAL 536 ? A VAL 501 
55 1 Y 1 F LEU 537 ? A LEU 502 
56 1 Y 1 F LEU 538 ? A LEU 503 
57 1 Y 1 F SER 539 ? A SER 504 
58 1 Y 1 F THR 540 ? A THR 505 
59 1 Y 1 F PHE 541 ? A PHE 506 
60 1 Y 1 F LEU 542 ? A LEU 507 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EDO C1   C N N 88  
EDO O1   O N N 89  
EDO C2   C N N 90  
EDO O2   O N N 91  
EDO H11  H N N 92  
EDO H12  H N N 93  
EDO HO1  H N N 94  
EDO H21  H N N 95  
EDO H22  H N N 96  
EDO HO2  H N N 97  
GLN N    N N N 98  
GLN CA   C N S 99  
GLN C    C N N 100 
GLN O    O N N 101 
GLN CB   C N N 102 
GLN CG   C N N 103 
GLN CD   C N N 104 
GLN OE1  O N N 105 
GLN NE2  N N N 106 
GLN OXT  O N N 107 
GLN H    H N N 108 
GLN H2   H N N 109 
GLN HA   H N N 110 
GLN HB2  H N N 111 
GLN HB3  H N N 112 
GLN HG2  H N N 113 
GLN HG3  H N N 114 
GLN HE21 H N N 115 
GLN HE22 H N N 116 
GLN HXT  H N N 117 
GLU N    N N N 118 
GLU CA   C N S 119 
GLU C    C N N 120 
GLU O    O N N 121 
GLU CB   C N N 122 
GLU CG   C N N 123 
GLU CD   C N N 124 
GLU OE1  O N N 125 
GLU OE2  O N N 126 
GLU OXT  O N N 127 
GLU H    H N N 128 
GLU H2   H N N 129 
GLU HA   H N N 130 
GLU HB2  H N N 131 
GLU HB3  H N N 132 
GLU HG2  H N N 133 
GLU HG3  H N N 134 
GLU HE2  H N N 135 
GLU HXT  H N N 136 
GLY N    N N N 137 
GLY CA   C N N 138 
GLY C    C N N 139 
GLY O    O N N 140 
GLY OXT  O N N 141 
GLY H    H N N 142 
GLY H2   H N N 143 
GLY HA2  H N N 144 
GLY HA3  H N N 145 
GLY HXT  H N N 146 
HIS N    N N N 147 
HIS CA   C N S 148 
HIS C    C N N 149 
HIS O    O N N 150 
HIS CB   C N N 151 
HIS CG   C Y N 152 
HIS ND1  N Y N 153 
HIS CD2  C Y N 154 
HIS CE1  C Y N 155 
HIS NE2  N Y N 156 
HIS OXT  O N N 157 
HIS H    H N N 158 
HIS H2   H N N 159 
HIS HA   H N N 160 
HIS HB2  H N N 161 
HIS HB3  H N N 162 
HIS HD1  H N N 163 
HIS HD2  H N N 164 
HIS HE1  H N N 165 
HIS HE2  H N N 166 
HIS HXT  H N N 167 
HOH O    O N N 168 
HOH H1   H N N 169 
HOH H2   H N N 170 
ILE N    N N N 171 
ILE CA   C N S 172 
ILE C    C N N 173 
ILE O    O N N 174 
ILE CB   C N S 175 
ILE CG1  C N N 176 
ILE CG2  C N N 177 
ILE CD1  C N N 178 
ILE OXT  O N N 179 
ILE H    H N N 180 
ILE H2   H N N 181 
ILE HA   H N N 182 
ILE HB   H N N 183 
ILE HG12 H N N 184 
ILE HG13 H N N 185 
ILE HG21 H N N 186 
ILE HG22 H N N 187 
ILE HG23 H N N 188 
ILE HD11 H N N 189 
ILE HD12 H N N 190 
ILE HD13 H N N 191 
ILE HXT  H N N 192 
LEU N    N N N 193 
LEU CA   C N S 194 
LEU C    C N N 195 
LEU O    O N N 196 
LEU CB   C N N 197 
LEU CG   C N N 198 
LEU CD1  C N N 199 
LEU CD2  C N N 200 
LEU OXT  O N N 201 
LEU H    H N N 202 
LEU H2   H N N 203 
LEU HA   H N N 204 
LEU HB2  H N N 205 
LEU HB3  H N N 206 
LEU HG   H N N 207 
LEU HD11 H N N 208 
LEU HD12 H N N 209 
LEU HD13 H N N 210 
LEU HD21 H N N 211 
LEU HD22 H N N 212 
LEU HD23 H N N 213 
LEU HXT  H N N 214 
LYS N    N N N 215 
LYS CA   C N S 216 
LYS C    C N N 217 
LYS O    O N N 218 
LYS CB   C N N 219 
LYS CG   C N N 220 
LYS CD   C N N 221 
LYS CE   C N N 222 
LYS NZ   N N N 223 
LYS OXT  O N N 224 
LYS H    H N N 225 
LYS H2   H N N 226 
LYS HA   H N N 227 
LYS HB2  H N N 228 
LYS HB3  H N N 229 
LYS HG2  H N N 230 
LYS HG3  H N N 231 
LYS HD2  H N N 232 
LYS HD3  H N N 233 
LYS HE2  H N N 234 
LYS HE3  H N N 235 
LYS HZ1  H N N 236 
LYS HZ2  H N N 237 
LYS HZ3  H N N 238 
LYS HXT  H N N 239 
MET N    N N N 240 
MET CA   C N S 241 
MET C    C N N 242 
MET O    O N N 243 
MET CB   C N N 244 
MET CG   C N N 245 
MET SD   S N N 246 
MET CE   C N N 247 
MET OXT  O N N 248 
MET H    H N N 249 
MET H2   H N N 250 
MET HA   H N N 251 
MET HB2  H N N 252 
MET HB3  H N N 253 
MET HG2  H N N 254 
MET HG3  H N N 255 
MET HE1  H N N 256 
MET HE2  H N N 257 
MET HE3  H N N 258 
MET HXT  H N N 259 
NAG C1   C N R 260 
NAG C2   C N R 261 
NAG C3   C N R 262 
NAG C4   C N S 263 
NAG C5   C N R 264 
NAG C6   C N N 265 
NAG C7   C N N 266 
NAG C8   C N N 267 
NAG N2   N N N 268 
NAG O1   O N N 269 
NAG O3   O N N 270 
NAG O4   O N N 271 
NAG O5   O N N 272 
NAG O6   O N N 273 
NAG O7   O N N 274 
NAG H1   H N N 275 
NAG H2   H N N 276 
NAG H3   H N N 277 
NAG H4   H N N 278 
NAG H5   H N N 279 
NAG H61  H N N 280 
NAG H62  H N N 281 
NAG H81  H N N 282 
NAG H82  H N N 283 
NAG H83  H N N 284 
NAG HN2  H N N 285 
NAG HO1  H N N 286 
NAG HO3  H N N 287 
NAG HO4  H N N 288 
NAG HO6  H N N 289 
PHE N    N N N 290 
PHE CA   C N S 291 
PHE C    C N N 292 
PHE O    O N N 293 
PHE CB   C N N 294 
PHE CG   C Y N 295 
PHE CD1  C Y N 296 
PHE CD2  C Y N 297 
PHE CE1  C Y N 298 
PHE CE2  C Y N 299 
PHE CZ   C Y N 300 
PHE OXT  O N N 301 
PHE H    H N N 302 
PHE H2   H N N 303 
PHE HA   H N N 304 
PHE HB2  H N N 305 
PHE HB3  H N N 306 
PHE HD1  H N N 307 
PHE HD2  H N N 308 
PHE HE1  H N N 309 
PHE HE2  H N N 310 
PHE HZ   H N N 311 
PHE HXT  H N N 312 
PRO N    N N N 313 
PRO CA   C N S 314 
PRO C    C N N 315 
PRO O    O N N 316 
PRO CB   C N N 317 
PRO CG   C N N 318 
PRO CD   C N N 319 
PRO OXT  O N N 320 
PRO H    H N N 321 
PRO HA   H N N 322 
PRO HB2  H N N 323 
PRO HB3  H N N 324 
PRO HG2  H N N 325 
PRO HG3  H N N 326 
PRO HD2  H N N 327 
PRO HD3  H N N 328 
PRO HXT  H N N 329 
SER N    N N N 330 
SER CA   C N S 331 
SER C    C N N 332 
SER O    O N N 333 
SER CB   C N N 334 
SER OG   O N N 335 
SER OXT  O N N 336 
SER H    H N N 337 
SER H2   H N N 338 
SER HA   H N N 339 
SER HB2  H N N 340 
SER HB3  H N N 341 
SER HG   H N N 342 
SER HXT  H N N 343 
THR N    N N N 344 
THR CA   C N S 345 
THR C    C N N 346 
THR O    O N N 347 
THR CB   C N R 348 
THR OG1  O N N 349 
THR CG2  C N N 350 
THR OXT  O N N 351 
THR H    H N N 352 
THR H2   H N N 353 
THR HA   H N N 354 
THR HB   H N N 355 
THR HG1  H N N 356 
THR HG21 H N N 357 
THR HG22 H N N 358 
THR HG23 H N N 359 
THR HXT  H N N 360 
TRP N    N N N 361 
TRP CA   C N S 362 
TRP C    C N N 363 
TRP O    O N N 364 
TRP CB   C N N 365 
TRP CG   C Y N 366 
TRP CD1  C Y N 367 
TRP CD2  C Y N 368 
TRP NE1  N Y N 369 
TRP CE2  C Y N 370 
TRP CE3  C Y N 371 
TRP CZ2  C Y N 372 
TRP CZ3  C Y N 373 
TRP CH2  C Y N 374 
TRP OXT  O N N 375 
TRP H    H N N 376 
TRP H2   H N N 377 
TRP HA   H N N 378 
TRP HB2  H N N 379 
TRP HB3  H N N 380 
TRP HD1  H N N 381 
TRP HE1  H N N 382 
TRP HE3  H N N 383 
TRP HZ2  H N N 384 
TRP HZ3  H N N 385 
TRP HH2  H N N 386 
TRP HXT  H N N 387 
TYR N    N N N 388 
TYR CA   C N S 389 
TYR C    C N N 390 
TYR O    O N N 391 
TYR CB   C N N 392 
TYR CG   C Y N 393 
TYR CD1  C Y N 394 
TYR CD2  C Y N 395 
TYR CE1  C Y N 396 
TYR CE2  C Y N 397 
TYR CZ   C Y N 398 
TYR OH   O N N 399 
TYR OXT  O N N 400 
TYR H    H N N 401 
TYR H2   H N N 402 
TYR HA   H N N 403 
TYR HB2  H N N 404 
TYR HB3  H N N 405 
TYR HD1  H N N 406 
TYR HD2  H N N 407 
TYR HE1  H N N 408 
TYR HE2  H N N 409 
TYR HH   H N N 410 
TYR HXT  H N N 411 
VAL N    N N N 412 
VAL CA   C N S 413 
VAL C    C N N 414 
VAL O    O N N 415 
VAL CB   C N N 416 
VAL CG1  C N N 417 
VAL CG2  C N N 418 
VAL OXT  O N N 419 
VAL H    H N N 420 
VAL H2   H N N 421 
VAL HA   H N N 422 
VAL HB   H N N 423 
VAL HG11 H N N 424 
VAL HG12 H N N 425 
VAL HG13 H N N 426 
VAL HG21 H N N 427 
VAL HG22 H N N 428 
VAL HG23 H N N 429 
VAL HXT  H N N 430 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
NAG C1  C2   sing N N 246 
NAG C1  O1   sing N N 247 
NAG C1  O5   sing N N 248 
NAG C1  H1   sing N N 249 
NAG C2  C3   sing N N 250 
NAG C2  N2   sing N N 251 
NAG C2  H2   sing N N 252 
NAG C3  C4   sing N N 253 
NAG C3  O3   sing N N 254 
NAG C3  H3   sing N N 255 
NAG C4  C5   sing N N 256 
NAG C4  O4   sing N N 257 
NAG C4  H4   sing N N 258 
NAG C5  C6   sing N N 259 
NAG C5  O5   sing N N 260 
NAG C5  H5   sing N N 261 
NAG C6  O6   sing N N 262 
NAG C6  H61  sing N N 263 
NAG C6  H62  sing N N 264 
NAG C7  C8   sing N N 265 
NAG C7  N2   sing N N 266 
NAG C7  O7   doub N N 267 
NAG C8  H81  sing N N 268 
NAG C8  H82  sing N N 269 
NAG C8  H83  sing N N 270 
NAG N2  HN2  sing N N 271 
NAG O1  HO1  sing N N 272 
NAG O3  HO3  sing N N 273 
NAG O4  HO4  sing N N 274 
NAG O6  HO6  sing N N 275 
PHE N   CA   sing N N 276 
PHE N   H    sing N N 277 
PHE N   H2   sing N N 278 
PHE CA  C    sing N N 279 
PHE CA  CB   sing N N 280 
PHE CA  HA   sing N N 281 
PHE C   O    doub N N 282 
PHE C   OXT  sing N N 283 
PHE CB  CG   sing N N 284 
PHE CB  HB2  sing N N 285 
PHE CB  HB3  sing N N 286 
PHE CG  CD1  doub Y N 287 
PHE CG  CD2  sing Y N 288 
PHE CD1 CE1  sing Y N 289 
PHE CD1 HD1  sing N N 290 
PHE CD2 CE2  doub Y N 291 
PHE CD2 HD2  sing N N 292 
PHE CE1 CZ   doub Y N 293 
PHE CE1 HE1  sing N N 294 
PHE CE2 CZ   sing Y N 295 
PHE CE2 HE2  sing N N 296 
PHE CZ  HZ   sing N N 297 
PHE OXT HXT  sing N N 298 
PRO N   CA   sing N N 299 
PRO N   CD   sing N N 300 
PRO N   H    sing N N 301 
PRO CA  C    sing N N 302 
PRO CA  CB   sing N N 303 
PRO CA  HA   sing N N 304 
PRO C   O    doub N N 305 
PRO C   OXT  sing N N 306 
PRO CB  CG   sing N N 307 
PRO CB  HB2  sing N N 308 
PRO CB  HB3  sing N N 309 
PRO CG  CD   sing N N 310 
PRO CG  HG2  sing N N 311 
PRO CG  HG3  sing N N 312 
PRO CD  HD2  sing N N 313 
PRO CD  HD3  sing N N 314 
PRO OXT HXT  sing N N 315 
SER N   CA   sing N N 316 
SER N   H    sing N N 317 
SER N   H2   sing N N 318 
SER CA  C    sing N N 319 
SER CA  CB   sing N N 320 
SER CA  HA   sing N N 321 
SER C   O    doub N N 322 
SER C   OXT  sing N N 323 
SER CB  OG   sing N N 324 
SER CB  HB2  sing N N 325 
SER CB  HB3  sing N N 326 
SER OG  HG   sing N N 327 
SER OXT HXT  sing N N 328 
THR N   CA   sing N N 329 
THR N   H    sing N N 330 
THR N   H2   sing N N 331 
THR CA  C    sing N N 332 
THR CA  CB   sing N N 333 
THR CA  HA   sing N N 334 
THR C   O    doub N N 335 
THR C   OXT  sing N N 336 
THR CB  OG1  sing N N 337 
THR CB  CG2  sing N N 338 
THR CB  HB   sing N N 339 
THR OG1 HG1  sing N N 340 
THR CG2 HG21 sing N N 341 
THR CG2 HG22 sing N N 342 
THR CG2 HG23 sing N N 343 
THR OXT HXT  sing N N 344 
TRP N   CA   sing N N 345 
TRP N   H    sing N N 346 
TRP N   H2   sing N N 347 
TRP CA  C    sing N N 348 
TRP CA  CB   sing N N 349 
TRP CA  HA   sing N N 350 
TRP C   O    doub N N 351 
TRP C   OXT  sing N N 352 
TRP CB  CG   sing N N 353 
TRP CB  HB2  sing N N 354 
TRP CB  HB3  sing N N 355 
TRP CG  CD1  doub Y N 356 
TRP CG  CD2  sing Y N 357 
TRP CD1 NE1  sing Y N 358 
TRP CD1 HD1  sing N N 359 
TRP CD2 CE2  doub Y N 360 
TRP CD2 CE3  sing Y N 361 
TRP NE1 CE2  sing Y N 362 
TRP NE1 HE1  sing N N 363 
TRP CE2 CZ2  sing Y N 364 
TRP CE3 CZ3  doub Y N 365 
TRP CE3 HE3  sing N N 366 
TRP CZ2 CH2  doub Y N 367 
TRP CZ2 HZ2  sing N N 368 
TRP CZ3 CH2  sing Y N 369 
TRP CZ3 HZ3  sing N N 370 
TRP CH2 HH2  sing N N 371 
TRP OXT HXT  sing N N 372 
TYR N   CA   sing N N 373 
TYR N   H    sing N N 374 
TYR N   H2   sing N N 375 
TYR CA  C    sing N N 376 
TYR CA  CB   sing N N 377 
TYR CA  HA   sing N N 378 
TYR C   O    doub N N 379 
TYR C   OXT  sing N N 380 
TYR CB  CG   sing N N 381 
TYR CB  HB2  sing N N 382 
TYR CB  HB3  sing N N 383 
TYR CG  CD1  doub Y N 384 
TYR CG  CD2  sing Y N 385 
TYR CD1 CE1  sing Y N 386 
TYR CD1 HD1  sing N N 387 
TYR CD2 CE2  doub Y N 388 
TYR CD2 HD2  sing N N 389 
TYR CE1 CZ   doub Y N 390 
TYR CE1 HE1  sing N N 391 
TYR CE2 CZ   sing Y N 392 
TYR CE2 HE2  sing N N 393 
TYR CZ  OH   sing N N 394 
TYR OH  HH   sing N N 395 
TYR OXT HXT  sing N N 396 
VAL N   CA   sing N N 397 
VAL N   H    sing N N 398 
VAL N   H2   sing N N 399 
VAL CA  C    sing N N 400 
VAL CA  CB   sing N N 401 
VAL CA  HA   sing N N 402 
VAL C   O    doub N N 403 
VAL C   OXT  sing N N 404 
VAL CB  CG1  sing N N 405 
VAL CB  CG2  sing N N 406 
VAL CB  HB   sing N N 407 
VAL CG1 HG11 sing N N 408 
VAL CG1 HG12 sing N N 409 
VAL CG1 HG13 sing N N 410 
VAL CG2 HG21 sing N N 411 
VAL CG2 HG22 sing N N 412 
VAL CG2 HG23 sing N N 413 
VAL OXT HXT  sing N N 414 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5K6I 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 41 3 2' 
_space_group.name_Hall        'P 4bd 2ab 3' 
_space_group.IT_number        213 
_space_group.crystal_system   cubic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W3L 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005935 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005935 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005935 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 30  ? 158.52954 332.70660 33.85731  1.000 82.60587  ? 26  GLN F N   1 
ATOM   2    C CA  . GLN A 1 30  ? 159.54723 333.71764 33.52507  1.000 80.83543  ? 26  GLN F CA  1 
ATOM   3    C C   . GLN A 1 30  ? 159.56300 334.94337 34.46917  1.000 77.75038  ? 26  GLN F C   1 
ATOM   4    O O   . GLN A 1 30  ? 158.63298 335.74501 34.48597  1.000 85.93024  ? 26  GLN F O   1 
ATOM   5    C CB  . GLN A 1 30  ? 159.36559 334.18272 32.06729  1.000 84.33123  ? 26  GLN F CB  1 
ATOM   6    C CG  . GLN A 1 30  ? 158.23890 335.19181 31.84086  1.000 81.54361  ? 26  GLN F CG  1 
ATOM   7    C CD  . GLN A 1 30  ? 158.51778 336.16681 30.69361  1.000 85.96129  ? 26  GLN F CD  1 
ATOM   8    O OE1 . GLN A 1 30  ? 159.33201 335.88874 29.80212  1.000 84.54596  ? 26  GLN F OE1 1 
ATOM   9    N NE2 . GLN A 1 30  ? 157.84074 337.32030 30.71736  1.000 72.84252  ? 26  GLN F NE2 1 
ATOM   10   N N   . ASN A 1 31  ? 160.57502 334.99598 35.33817  1.000 75.09707  ? 27  ASN F N   1 
ATOM   11   C CA  . ASN A 1 31  ? 160.77018 336.07114 36.31975  1.000 67.55869  ? 27  ASN F CA  1 
ATOM   12   C C   . ASN A 1 31  ? 161.70145 337.17868 35.77685  1.000 64.51756  ? 27  ASN F C   1 
ATOM   13   O O   . ASN A 1 31  ? 162.81295 337.37982 36.28578  1.000 57.30941  ? 27  ASN F O   1 
ATOM   14   C CB  . ASN A 1 31  ? 161.32390 335.45880 37.60612  1.000 67.63935  ? 27  ASN F CB  1 
ATOM   15   C CG  . ASN A 1 31  ? 161.12102 336.34400 38.83818  1.000 76.87539  ? 27  ASN F CG  1 
ATOM   16   O OD1 . ASN A 1 31  ? 160.80008 337.52608 38.72200  1.000 83.44196  ? 27  ASN F OD1 1 
ATOM   17   N ND2 . ASN A 1 31  ? 161.35134 335.77592 40.02525  1.000 73.99963  ? 27  ASN F ND2 1 
ATOM   18   N N   . ILE A 1 32  ? 161.25000 337.95558 34.77591  1.000 50.81519  ? 28  ILE F N   1 
ATOM   19   C CA  . ILE A 1 32  ? 162.11310 339.04046 34.26781  1.000 48.77884  ? 28  ILE F CA  1 
ATOM   20   C C   . ILE A 1 32  ? 162.03058 340.28172 35.15417  1.000 50.82895  ? 28  ILE F C   1 
ATOM   21   O O   . ILE A 1 32  ? 160.93521 340.80181 35.39803  1.000 54.66042  ? 28  ILE F O   1 
ATOM   22   C CB  . ILE A 1 32  ? 161.74488 339.43127 32.82715  1.000 48.75166  ? 28  ILE F CB  1 
ATOM   23   C CG1 . ILE A 1 32  ? 161.90025 338.27694 31.86658  1.000 52.21833  ? 28  ILE F CG1 1 
ATOM   24   C CG2 . ILE A 1 32  ? 162.66943 340.53676 32.35989  1.000 53.91347  ? 28  ILE F CG2 1 
ATOM   25   C CD1 . ILE A 1 32  ? 163.27757 337.78942 31.81114  1.000 52.75845  ? 28  ILE F CD1 1 
ATOM   26   N N   . THR A 1 33  ? 163.18340 340.77451 35.63882  1.000 41.33950  ? 29  THR F N   1 
ATOM   27   C CA  . THR A 1 33  ? 163.18163 341.99111 36.45268  1.000 49.05868  ? 29  THR F CA  1 
ATOM   28   C C   . THR A 1 33  ? 164.22262 342.97873 35.90650  1.000 46.25274  ? 29  THR F C   1 
ATOM   29   O O   . THR A 1 33  ? 165.15476 342.60316 35.19165  1.000 45.16402  ? 29  THR F O   1 
ATOM   30   C CB  . THR A 1 33  ? 163.47212 341.71329 37.94193  1.000 47.05956  ? 29  THR F CB  1 
ATOM   31   O OG1 . THR A 1 33  ? 164.72109 341.05245 38.05009  1.000 50.90182  ? 29  THR F OG1 1 
ATOM   32   C CG2 . THR A 1 33  ? 162.39112 340.78154 38.52496  1.000 47.16524  ? 29  THR F CG2 1 
ATOM   33   N N   . GLU A 1 34  ? 164.10889 344.24349 36.31082  1.000 45.40773  ? 30  GLU F N   1 
ATOM   34   C CA  . GLU A 1 34  ? 165.03055 345.28109 35.84842  1.000 48.52922  ? 30  GLU F CA  1 
ATOM   35   C C   . GLU A 1 34  ? 165.40740 346.20325 36.99538  1.000 44.76235  ? 30  GLU F C   1 
ATOM   36   O O   . GLU A 1 34  ? 164.56191 346.54946 37.81780  1.000 49.87373  ? 30  GLU F O   1 
ATOM   37   C CB  . GLU A 1 34  ? 164.41441 346.09578 34.69639  1.000 38.73120  ? 30  GLU F CB  1 
ATOM   38   C CG  . GLU A 1 34  ? 165.40388 346.86912 33.87779  1.000 39.22462  ? 30  GLU F CG  1 
ATOM   39   C CD  . GLU A 1 34  ? 164.83945 347.24180 32.50635  1.000 47.49258  ? 30  GLU F CD  1 
ATOM   40   O OE1 . GLU A 1 34  ? 164.16718 348.30594 32.39476  1.000 45.08405  ? 30  GLU F OE1 1 
ATOM   41   O OE2 . GLU A 1 34  ? 165.05249 346.45350 31.54498  1.000 44.63348  ? 30  GLU F OE2 1 
ATOM   42   N N   . GLU A 1 35  ? 166.58936 346.80279 36.89296  1.000 47.30637  ? 31  GLU F N   1 
ATOM   43   C CA  . GLU A 1 35  ? 167.08460 347.74171 37.90336  1.000 46.29961  ? 31  GLU F CA  1 
ATOM   44   C C   . GLU A 1 35  ? 167.76992 348.91318 37.23129  1.000 44.66467  ? 31  GLU F C   1 
ATOM   45   O O   . GLU A 1 35  ? 168.63279 348.70059 36.37073  1.000 41.90562  ? 31  GLU F O   1 
ATOM   46   C CB  . GLU A 1 35  ? 168.07175 347.10164 38.88491  1.000 43.84913  ? 31  GLU F CB  1 
ATOM   47   C CG  . GLU A 1 35  ? 167.47556 346.14676 39.91612  1.000 54.17688  ? 31  GLU F CG  1 
ATOM   48   C CD  . GLU A 1 35  ? 168.56093 345.47784 40.78082  1.000 61.62042  ? 31  GLU F CD  1 
ATOM   49   O OE1 . GLU A 1 35  ? 169.75399 345.87506 40.65820  1.000 59.01711  ? 31  GLU F OE1 1 
ATOM   50   O OE2 . GLU A 1 35  ? 168.22606 344.54639 41.55784  1.000 68.62284  ? 31  GLU F OE2 1 
ATOM   51   N N   . PHE A 1 36  ? 167.22415 350.10982 37.43357  1.000 38.01886  ? 32  PHE F N   1 
ATOM   52   C CA  . PHE A 1 36  ? 167.84496 351.33924 36.95402  1.000 36.91817  ? 32  PHE F CA  1 
ATOM   53   C C   . PHE A 1 36  ? 168.67415 351.97179 38.06924  1.000 45.04740  ? 32  PHE F C   1 
ATOM   54   O O   . PHE A 1 36  ? 168.18915 352.12579 39.19793  1.000 45.49558  ? 32  PHE F O   1 
ATOM   55   C CB  . PHE A 1 36  ? 166.80537 352.32962 36.45625  1.000 36.82304  ? 32  PHE F CB  1 
ATOM   56   C CG  . PHE A 1 36  ? 167.37736 353.66705 36.16377  1.000 39.34633  ? 32  PHE F CG  1 
ATOM   57   C CD1 . PHE A 1 36  ? 168.12208 353.88374 35.00378  1.000 36.01306  ? 32  PHE F CD1 1 
ATOM   58   C CD2 . PHE A 1 36  ? 167.10188 354.73018 36.99252  1.000 37.31641  ? 32  PHE F CD2 1 
ATOM   59   C CE1 . PHE A 1 36  ? 168.65006 355.14067 34.70600  1.000 37.96792  ? 32  PHE F CE1 1 
ATOM   60   C CE2 . PHE A 1 36  ? 167.60415 355.99408 36.70380  1.000 40.95460  ? 32  PHE F CE2 1 
ATOM   61   C CZ  . PHE A 1 36  ? 168.39124 356.19607 35.55010  1.000 43.95790  ? 32  PHE F CZ  1 
ATOM   62   N N   . TYR A 1 37  ? 169.92779 352.33464 37.75325  1.000 43.32885  ? 33  TYR F N   1 
ATOM   63   C CA  . TYR A 1 37  ? 170.84943 352.92074 38.72926  1.000 40.49661  ? 33  TYR F CA  1 
ATOM   64   C C   . TYR A 1 37  ? 170.91191 354.39994 38.36450  1.000 40.87882  ? 33  TYR F C   1 
ATOM   65   O O   . TYR A 1 37  ? 171.54134 354.78954 37.37281  1.000 40.13946  ? 33  TYR F O   1 
ATOM   66   C CB  . TYR A 1 37  ? 172.22529 352.24779 38.68706  1.000 41.49094  ? 33  TYR F CB  1 
ATOM   67   C CG  . TYR A 1 37  ? 172.05998 350.75250 38.80810  1.000 47.89945  ? 33  TYR F CG  1 
ATOM   68   C CD1 . TYR A 1 37  ? 171.82290 350.13578 40.02144  1.000 46.30137  ? 33  TYR F CD1 1 
ATOM   69   C CD2 . TYR A 1 37  ? 172.26093 349.94338 37.69674  1.000 46.66248  ? 33  TYR F CD2 1 
ATOM   70   C CE1 . TYR A 1 37  ? 171.65875 348.75047 40.09654  1.000 48.69375  ? 33  TYR F CE1 1 
ATOM   71   C CE2 . TYR A 1 37  ? 172.13014 348.56490 37.76753  1.000 46.15899  ? 33  TYR F CE2 1 
ATOM   72   C CZ  . TYR A 1 37  ? 171.82815 347.97226 38.95436  1.000 48.87632  ? 33  TYR F CZ  1 
ATOM   73   O OH  . TYR A 1 37  ? 171.68459 346.59762 38.97706  1.000 52.05379  ? 33  TYR F OH  1 
ATOM   74   N N   . GLN A 1 38  ? 170.24674 355.22815 39.16074  1.000 45.64530  ? 34  GLN F N   1 
ATOM   75   C CA  . GLN A 1 38  ? 170.25057 356.65827 38.89504  1.000 41.39649  ? 34  GLN F CA  1 
ATOM   76   C C   . GLN A 1 38  ? 171.64813 357.23630 38.95543  1.000 44.24780  ? 34  GLN F C   1 
ATOM   77   O O   . GLN A 1 38  ? 171.97146 358.18054 38.21491  1.000 44.89789  ? 34  GLN F O   1 
ATOM   78   C CB  . GLN A 1 38  ? 169.38436 357.36653 39.92669  1.000 48.12015  ? 34  GLN F CB  1 
ATOM   79   C CG  . GLN A 1 38  ? 169.35187 358.86901 39.78497  1.000 48.75483  ? 34  GLN F CG  1 
ATOM   80   C CD  . GLN A 1 38  ? 168.55909 359.55054 40.91786  1.000 53.17819  ? 34  GLN F CD  1 
ATOM   81   O OE1 . GLN A 1 38  ? 167.53910 359.05122 41.36504  1.000 59.22927  ? 34  GLN F OE1 1 
ATOM   82   N NE2 . GLN A 1 38  ? 168.97355 360.73922 41.28301  1.000 62.39757  ? 34  GLN F NE2 1 
ATOM   83   N N   . SER A 1 39  ? 172.51900 356.61968 39.74263  1.000 41.21033  ? 35  SER F N   1 
ATOM   84   C CA  . SER A 1 39  ? 173.86625 357.15905 39.93134  1.000 43.87400  ? 35  SER F CA  1 
ATOM   85   C C   . SER A 1 39  ? 174.75378 357.03041 38.68969  1.000 42.40228  ? 35  SER F C   1 
ATOM   86   O O   . SER A 1 39  ? 175.68052 357.82530 38.52400  1.000 39.80026  ? 35  SER F O   1 
ATOM   87   C CB  . SER A 1 39  ? 174.48292 356.47626 41.14264  1.000 43.08004  ? 35  SER F CB  1 
ATOM   88   O OG  . SER A 1 39  ? 174.55500 355.07172 40.92433  1.000 49.80399  ? 35  SER F OG  1 
ATOM   89   N N   . THR A 1 40  ? 174.57938 355.98611 37.87421  1.000 39.48512  ? 36  THR F N   1 
ATOM   90   C CA  . THR A 1 40  ? 175.44293 355.76979 36.71537  1.000 42.49058  ? 36  THR F CA  1 
ATOM   91   C C   . THR A 1 40  ? 174.70205 355.78051 35.38597  1.000 38.66206  ? 36  THR F C   1 
ATOM   92   O O   . THR A 1 40  ? 175.31442 355.48306 34.35199  1.000 39.96759  ? 36  THR F O   1 
ATOM   93   C CB  . THR A 1 40  ? 176.24067 354.47651 36.84664  1.000 42.38882  ? 36  THR F CB  1 
ATOM   94   O OG1 . THR A 1 40  ? 175.34459 353.38252 37.08267  1.000 39.39758  ? 36  THR F OG1 1 
ATOM   95   C CG2 . THR A 1 40  ? 177.18199 354.66452 38.02309  1.000 40.70535  ? 36  THR F CG2 1 
ATOM   96   N N   . CYS A 1 41  ? 173.39971 356.04911 35.38713  1.000 39.10368  ? 37  CYS F N   1 
ATOM   97   C CA  . CYS A 1 41  ? 172.61999 356.09390 34.16002  1.000 38.08225  ? 37  CYS F CA  1 
ATOM   98   C C   . CYS A 1 41  ? 172.71728 354.76705 33.38857  1.000 40.03684  ? 37  CYS F C   1 
ATOM   99   O O   . CYS A 1 41  ? 173.11937 354.71696 32.22639  1.000 37.81366  ? 37  CYS F O   1 
ATOM   100  C CB  . CYS A 1 41  ? 173.11107 357.27662 33.31547  1.000 33.23967  ? 37  CYS F CB  1 
ATOM   101  S SG  . CYS A 1 41  ? 172.06824 357.77203 31.90938  1.000 44.34159  ? 37  CYS F SG  1 
ATOM   102  N N   . SER A 1 42  ? 172.47973 353.66880 34.09499  1.000 33.87236  ? 38  SER F N   1 
ATOM   103  C CA  . SER A 1 42  ? 172.57450 352.34254 33.51576  1.000 35.55165  ? 38  SER F CA  1 
ATOM   104  C C   . SER A 1 42  ? 171.47769 351.51159 34.15274  1.000 41.30836  ? 38  SER F C   1 
ATOM   105  O O   . SER A 1 42  ? 170.91731 351.89717 35.17989  1.000 41.27501  ? 38  SER F O   1 
ATOM   106  C CB  . SER A 1 42  ? 173.91153 351.68028 33.76590  1.000 35.27194  ? 38  SER F CB  1 
ATOM   107  O OG  . SER A 1 42  ? 174.21496 351.73365 35.13786  1.000 41.10182  ? 38  SER F OG  1 
ATOM   108  N N   . ALA A 1 43  ? 171.05684 350.47575 33.43889  1.000 36.46073  ? 39  ALA F N   1 
ATOM   109  C CA  . ALA A 1 43  ? 170.03304 349.53239 33.86806  1.000 38.29182  ? 39  ALA F CA  1 
ATOM   110  C C   . ALA A 1 43  ? 170.48581 348.10402 33.57395  1.000 39.08881  ? 39  ALA F C   1 
ATOM   111  O O   . ALA A 1 43  ? 171.21568 347.86270 32.60827  1.000 37.02831  ? 39  ALA F O   1 
ATOM   112  C CB  . ALA A 1 43  ? 168.67534 349.80883 33.21686  1.000 38.29177  ? 39  ALA F CB  1 
ATOM   113  N N   . VAL A 1 44  ? 170.05608 347.16414 34.40697  1.000 39.38164  ? 40  VAL F N   1 
ATOM   114  C CA  . VAL A 1 44  ? 170.35677 345.74432 34.24539  1.000 37.98599  ? 40  VAL F CA  1 
ATOM   115  C C   . VAL A 1 44  ? 169.04844 344.96717 34.21698  1.000 42.76814  ? 40  VAL F C   1 
ATOM   116  O O   . VAL A 1 44  ? 168.19279 345.14175 35.09051  1.000 45.13201  ? 40  VAL F O   1 
ATOM   117  C CB  . VAL A 1 44  ? 171.27877 345.19347 35.33889  1.000 38.81010  ? 40  VAL F CB  1 
ATOM   118  C CG1 . VAL A 1 44  ? 171.50837 343.72634 35.07808  1.000 40.34461  ? 40  VAL F CG1 1 
ATOM   119  C CG2 . VAL A 1 44  ? 172.63985 345.84564 35.20783  1.000 41.15651  ? 40  VAL F CG2 1 
ATOM   120  N N   . SER A 1 45  ? 168.83970 344.22926 33.13148  1.000 39.46730  ? 41  SER F N   1 
ATOM   121  C CA  . SER A 1 45  ? 167.67142 343.38008 32.94201  1.000 44.39364  ? 41  SER F CA  1 
ATOM   122  C C   . SER A 1 45  ? 168.08302 341.96041 33.34764  1.000 43.16390  ? 41  SER F C   1 
ATOM   123  O O   . SER A 1 45  ? 168.97478 341.38044 32.71126  1.000 43.57615  ? 41  SER F O   1 
ATOM   124  C CB  . SER A 1 45  ? 167.24835 343.42228 31.47557  1.000 42.20109  ? 41  SER F CB  1 
ATOM   125  O OG  . SER A 1 45  ? 166.98865 344.75155 31.05728  1.000 48.04134  ? 41  SER F OG  1 
ATOM   126  N N   . LYS A 1 46  ? 167.53166 341.45032 34.45980  1.000 46.74020  ? 42  LYS F N   1 
ATOM   127  C CA  . LYS A 1 46  ? 167.83766 340.13012 35.02382  1.000 46.82770  ? 42  LYS F CA  1 
ATOM   128  C C   . LYS A 1 46  ? 166.73762 339.10529 34.77967  1.000 46.72106  ? 42  LYS F C   1 
ATOM   129  O O   . LYS A 1 46  ? 165.59973 339.43741 34.45357  1.000 46.52203  ? 42  LYS F O   1 
ATOM   130  C CB  . LYS A 1 46  ? 168.11335 340.18391 36.53709  1.000 50.91001  ? 42  LYS F CB  1 
ATOM   131  C CG  . LYS A 1 46  ? 169.34721 340.97049 36.90683  1.000 61.82560  ? 42  LYS F CG  1 
ATOM   132  C CD  . LYS A 1 46  ? 169.57694 341.12319 38.42056  1.000 59.31370  ? 42  LYS F CD  1 
ATOM   133  C CE  . LYS A 1 46  ? 168.31157 341.22979 39.23490  1.000 67.74814  ? 42  LYS F CE  1 
ATOM   134  N NZ  . LYS A 1 46  ? 168.72169 341.52070 40.65799  1.000 75.72511  ? 42  LYS F NZ  1 
ATOM   135  N N   . GLY A 1 47  ? 167.06330 337.83986 35.07078  1.000 46.58027  ? 43  GLY F N   1 
ATOM   136  C CA  . GLY A 1 47  ? 166.07239 336.78390 35.03184  1.000 41.74122  ? 43  GLY F CA  1 
ATOM   137  C C   . GLY A 1 47  ? 166.08345 335.93146 33.78501  1.000 48.73456  ? 43  GLY F C   1 
ATOM   138  O O   . GLY A 1 47  ? 165.17807 335.10468 33.61479  1.000 50.32975  ? 43  GLY F O   1 
ATOM   139  N N   . TYR A 1 48  ? 167.01202 336.16926 32.86418  1.000 42.79824  ? 44  TYR F N   1 
ATOM   140  C CA  . TYR A 1 48  ? 167.04550 335.41171 31.62687  1.000 44.44734  ? 44  TYR F CA  1 
ATOM   141  C C   . TYR A 1 48  ? 167.79030 334.11085 31.85337  1.000 43.87385  ? 44  TYR F C   1 
ATOM   142  O O   . TYR A 1 48  ? 168.68080 334.02848 32.70600  1.000 46.41303  ? 44  TYR F O   1 
ATOM   143  C CB  . TYR A 1 48  ? 167.72458 336.21736 30.52420  1.000 50.33307  ? 44  TYR F CB  1 
ATOM   144  C CG  . TYR A 1 48  ? 166.90787 337.42193 30.11155  1.000 47.80170  ? 44  TYR F CG  1 
ATOM   145  C CD1 . TYR A 1 48  ? 165.90551 337.31201 29.15825  1.000 48.45124  ? 44  TYR F CD1 1 
ATOM   146  C CD2 . TYR A 1 48  ? 167.13836 338.67029 30.69753  1.000 41.54494  ? 44  TYR F CD2 1 
ATOM   147  C CE1 . TYR A 1 48  ? 165.16364 338.41392 28.78059  1.000 46.12021  ? 44  TYR F CE1 1 
ATOM   148  C CE2 . TYR A 1 48  ? 166.39183 339.78338 30.33720  1.000 42.91938  ? 44  TYR F CE2 1 
ATOM   149  C CZ  . TYR A 1 48  ? 165.41558 339.64804 29.36744  1.000 44.45809  ? 44  TYR F CZ  1 
ATOM   150  O OH  . TYR A 1 48  ? 164.67395 340.73685 28.98519  1.000 47.53083  ? 44  TYR F OH  1 
ATOM   151  N N   . LEU A 1 49  ? 167.32266 333.06592 31.20210  1.000 47.53606  ? 45  LEU F N   1 
ATOM   152  C CA  . LEU A 1 49  ? 167.96475 331.76047 31.24434  1.000 41.89438  ? 45  LEU F CA  1 
ATOM   153  C C   . LEU A 1 49  ? 168.74202 331.57596 29.94831  1.000 40.06741  ? 45  LEU F C   1 
ATOM   154  O O   . LEU A 1 49  ? 168.15415 331.61281 28.86777  1.000 41.51081  ? 45  LEU F O   1 
ATOM   155  C CB  . LEU A 1 49  ? 166.89941 330.67942 31.41484  1.000 42.38320  ? 45  LEU F CB  1 
ATOM   156  C CG  . LEU A 1 49  ? 166.12879 330.81390 32.74615  1.000 50.06910  ? 45  LEU F CG  1 
ATOM   157  C CD1 . LEU A 1 49  ? 165.03083 329.77398 32.86437  1.000 50.71030  ? 45  LEU F CD1 1 
ATOM   158  C CD2 . LEU A 1 49  ? 167.04753 330.75678 33.98316  1.000 48.46154  ? 45  LEU F CD2 1 
ATOM   159  N N   . GLY A 1 50  ? 170.04776 331.39664 30.04499  1.000 42.03536  ? 46  GLY F N   1 
ATOM   160  C CA  . GLY A 1 50  ? 170.89304 331.32402 28.87842  1.000 36.83720  ? 46  GLY F CA  1 
ATOM   161  C C   . GLY A 1 50  ? 171.19335 329.89505 28.46170  1.000 44.84564  ? 46  GLY F C   1 
ATOM   162  O O   . GLY A 1 50  ? 171.37055 329.00357 29.29356  1.000 46.74649  ? 46  GLY F O   1 
ATOM   163  N N   . ALA A 1 51  ? 171.41507 329.73545 27.16659  1.000 37.55886  ? 47  ALA F N   1 
ATOM   164  C CA  . ALA A 1 51  ? 171.82610 328.49426 26.53624  1.000 38.65689  ? 47  ALA F CA  1 
ATOM   165  C C   . ALA A 1 51  ? 173.00186 328.90211 25.65819  1.000 42.49465  ? 47  ALA F C   1 
ATOM   166  O O   . ALA A 1 51  ? 172.83151 329.68149 24.71972  1.000 45.41035  ? 47  ALA F O   1 
ATOM   167  C CB  . ALA A 1 51  ? 170.69629 327.84205 25.74462  1.000 40.71948  ? 47  ALA F CB  1 
ATOM   168  N N   . LEU A 1 52  ? 174.20402 328.63049 26.13908  1.000 46.43221  ? 48  LEU F N   1 
ATOM   169  C CA  . LEU A 1 52  ? 175.45404 329.00764 25.48989  1.000 45.42915  ? 48  LEU F CA  1 
ATOM   170  C C   . LEU A 1 52  ? 175.99570 327.86616 24.64881  1.000 48.01580  ? 48  LEU F C   1 
ATOM   171  O O   . LEU A 1 52  ? 176.06364 326.72598 25.11609  1.000 48.37383  ? 48  LEU F O   1 
ATOM   172  C CB  . LEU A 1 52  ? 176.48616 329.44696 26.52085  1.000 47.45951  ? 48  LEU F CB  1 
ATOM   173  C CG  . LEU A 1 52  ? 175.89798 330.51454 27.44174  1.000 45.06744  ? 48  LEU F CG  1 
ATOM   174  C CD1 . LEU A 1 52  ? 176.98049 331.05536 28.34651  1.000 44.88880  ? 48  LEU F CD1 1 
ATOM   175  C CD2 . LEU A 1 52  ? 175.26142 331.62583 26.60425  1.000 35.19997  ? 48  LEU F CD2 1 
ATOM   176  N N   . ARG A 1 53  ? 176.38841 328.15436 23.41971  1.000 44.46141  ? 49  ARG F N   1 
ATOM   177  C CA  . ARG A 1 53  ? 176.95085 327.08556 22.61673  1.000 46.16923  ? 49  ARG F CA  1 
ATOM   178  C C   . ARG A 1 53  ? 178.38854 326.81501 23.03163  1.000 48.90641  ? 49  ARG F C   1 
ATOM   179  O O   . ARG A 1 53  ? 179.25924 327.68471 22.86860  1.000 49.41745  ? 49  ARG F O   1 
ATOM   180  C CB  . ARG A 1 53  ? 176.92800 327.42762 21.12433  1.000 48.06974  ? 49  ARG F CB  1 
ATOM   181  C CG  . ARG A 1 53  ? 176.91785 326.15122 20.27828  1.000 41.55406  ? 49  ARG F CG  1 
ATOM   182  C CD  . ARG A 1 53  ? 177.68200 326.27658 18.99426  1.000 43.74596  ? 49  ARG F CD  1 
ATOM   183  N NE  . ARG A 1 53  ? 178.82118 327.17388 19.07463  1.000 47.80684  ? 49  ARG F NE  1 
ATOM   184  C CZ  . ARG A 1 53  ? 180.05845 326.80456 19.39750  1.000 55.46849  ? 49  ARG F CZ  1 
ATOM   185  N NH1 . ARG A 1 53  ? 180.35574 325.54302 19.71869  1.000 50.68600  ? 49  ARG F NH1 1 
ATOM   186  N NH2 . ARG A 1 53  ? 181.02129 327.72235 19.40944  1.000 46.94201  ? 49  ARG F NH2 1 
ATOM   187  N N   . THR A 1 54  ? 178.65804 325.53801 23.38005  1.000 47.91752  ? 50  THR F N   1 
ATOM   188  C CA  . THR A 1 54  ? 179.96420 325.05879 23.82088  1.000 44.13617  ? 50  THR F CA  1 
ATOM   189  C C   . THR A 1 54  ? 180.50546 323.90631 22.99201  1.000 39.20012  ? 50  THR F C   1 
ATOM   190  O O   . THR A 1 54  ? 181.70165 323.65298 23.05647  1.000 46.96308  ? 50  THR F O   1 
ATOM   191  C CB  . THR A 1 54  ? 179.88864 324.55668 25.27982  1.000 46.76255  ? 50  THR F CB  1 
ATOM   192  O OG1 . THR A 1 54  ? 178.97861 323.44443 25.35536  1.000 47.80065  ? 50  THR F OG1 1 
ATOM   193  C CG2 . THR A 1 54  ? 179.36753 325.64284 26.22461  1.000 51.36078  ? 50  THR F CG2 1 
ATOM   194  N N   . GLY A 1 55  ? 179.67483 323.22037 22.19684  1.000 50.25857  ? 51  GLY F N   1 
ATOM   195  C CA  . GLY A 1 55  ? 180.12245 322.12528 21.35718  1.000 45.67026  ? 51  GLY F CA  1 
ATOM   196  C C   . GLY A 1 55  ? 179.36826 322.10335 20.03574  1.000 48.76876  ? 51  GLY F C   1 
ATOM   197  O O   . GLY A 1 55  ? 178.40761 322.85175 19.83372  1.000 46.17860  ? 51  GLY F O   1 
ATOM   198  N N   . TRP A 1 56  ? 179.79344 321.18989 19.15605  1.000 51.78916  ? 52  TRP F N   1 
ATOM   199  C CA  . TRP A 1 56  ? 179.20996 320.98134 17.83341  1.000 45.95932  ? 52  TRP F CA  1 
ATOM   200  C C   . TRP A 1 56  ? 178.83458 319.51902 17.62639  1.000 54.56334  ? 52  TRP F C   1 
ATOM   201  O O   . TRP A 1 56  ? 179.58123 318.61813 18.03002  1.000 48.12577  ? 52  TRP F O   1 
ATOM   202  C CB  . TRP A 1 56  ? 180.15695 321.40301 16.70507  1.000 46.13942  ? 52  TRP F CB  1 
ATOM   203  C CG  . TRP A 1 56  ? 180.44928 322.87009 16.63569  1.000 52.50455  ? 52  TRP F CG  1 
ATOM   204  C CD1 . TRP A 1 56  ? 181.62385 323.48030 16.93631  1.000 52.99063  ? 52  TRP F CD1 1 
ATOM   205  C CD2 . TRP A 1 56  ? 179.54672 323.90933 16.23055  1.000 48.18171  ? 52  TRP F CD2 1 
ATOM   206  N NE1 . TRP A 1 56  ? 181.52026 324.83226 16.73057  1.000 58.23894  ? 52  TRP F NE1 1 
ATOM   207  C CE2 . TRP A 1 56  ? 180.26232 325.12166 16.27866  1.000 52.14992  ? 52  TRP F CE2 1 
ATOM   208  C CE3 . TRP A 1 56  ? 178.21682 323.92387 15.78511  1.000 49.82793  ? 52  TRP F CE3 1 
ATOM   209  C CZ2 . TRP A 1 56  ? 179.68669 326.35236 15.93671  1.000 53.14864  ? 52  TRP F CZ2 1 
ATOM   210  C CZ3 . TRP A 1 56  ? 177.64180 325.13990 15.43842  1.000 49.01611  ? 52  TRP F CZ3 1 
ATOM   211  C CH2 . TRP A 1 56  ? 178.38020 326.34449 15.52228  1.000 49.47132  ? 52  TRP F CH2 1 
ATOM   212  N N   . TYR A 1 57  ? 177.70465 319.28519 16.94868  1.000 49.49693  ? 53  TYR F N   1 
ATOM   213  C CA  . TYR A 1 57  ? 177.29180 317.94681 16.53000  1.000 53.98925  ? 53  TYR F CA  1 
ATOM   214  C C   . TYR A 1 57  ? 177.21244 317.93132 15.00934  1.000 55.18875  ? 53  TYR F C   1 
ATOM   215  O O   . TYR A 1 57  ? 176.42812 318.69194 14.42528  1.000 53.63353  ? 53  TYR F O   1 
ATOM   216  C CB  . TYR A 1 57  ? 175.94296 317.54267 17.13809  1.000 52.51932  ? 53  TYR F CB  1 
ATOM   217  C CG  . TYR A 1 57  ? 175.44359 316.18877 16.63529  1.000 67.14157  ? 53  TYR F CG  1 
ATOM   218  C CD1 . TYR A 1 57  ? 174.47185 316.09146 15.62550  1.000 65.84482  ? 53  TYR F CD1 1 
ATOM   219  C CD2 . TYR A 1 57  ? 175.96440 314.99352 17.16940  1.000 66.12446  ? 53  TYR F CD2 1 
ATOM   220  C CE1 . TYR A 1 57  ? 174.03177 314.83787 15.16457  1.000 68.37082  ? 53  TYR F CE1 1 
ATOM   221  C CE2 . TYR A 1 57  ? 175.53615 313.74973 16.72402  1.000 67.11987  ? 53  TYR F CE2 1 
ATOM   222  C CZ  . TYR A 1 57  ? 174.56721 313.67309 15.72302  1.000 78.14455  ? 53  TYR F CZ  1 
ATOM   223  O OH  . TYR A 1 57  ? 174.14704 312.43188 15.28411  1.000 80.97704  ? 53  TYR F OH  1 
ATOM   224  N N   . THR A 1 58  ? 178.13118 317.21098 14.36248  1.000 52.48040  ? 54  THR F N   1 
ATOM   225  C CA  . THR A 1 58  ? 178.13249 317.15862 12.90557  1.000 61.01504  ? 54  THR F CA  1 
ATOM   226  C C   . THR A 1 58  ? 177.32990 315.94679 12.43897  1.000 65.24997  ? 54  THR F C   1 
ATOM   227  O O   . THR A 1 58  ? 177.26243 314.91643 13.11730  1.000 70.09193  ? 54  THR F O   1 
ATOM   228  C CB  . THR A 1 58  ? 179.54534 317.10318 12.32718  1.000 57.40349  ? 54  THR F CB  1 
ATOM   229  O OG1 . THR A 1 58  ? 180.19946 315.92193 12.79521  1.000 69.80510  ? 54  THR F OG1 1 
ATOM   230  C CG2 . THR A 1 58  ? 180.32447 318.31484 12.76918  1.000 50.92445  ? 54  THR F CG2 1 
ATOM   231  N N   . SER A 1 59  ? 176.74947 316.07234 11.25026  1.000 67.98599  ? 55  SER F N   1 
ATOM   232  C CA  . SER A 1 59  ? 175.96348 315.02151 10.61849  1.000 69.70898  ? 55  SER F CA  1 
ATOM   233  C C   . SER A 1 59  ? 176.16364 315.12943 9.11508   1.000 62.08641  ? 55  SER F C   1 
ATOM   234  O O   . SER A 1 59  ? 176.35237 316.23332 8.60235   1.000 59.01364  ? 55  SER F O   1 
ATOM   235  C CB  . SER A 1 59  ? 174.47486 315.13415 10.97167  1.000 72.57719  ? 55  SER F CB  1 
ATOM   236  O OG  . SER A 1 59  ? 173.73840 314.06882 10.39429  1.000 79.46154  ? 55  SER F OG  1 
ATOM   237  N N   . VAL A 1 60  ? 176.23625 313.97760 8.43487   1.000 71.53780  ? 56  VAL F N   1 
ATOM   238  C CA  . VAL A 1 60  ? 176.46856 313.93393 6.99244   1.000 69.08665  ? 56  VAL F CA  1 
ATOM   239  C C   . VAL A 1 60  ? 175.13739 313.83623 6.24997   1.000 71.24080  ? 56  VAL F C   1 
ATOM   240  O O   . VAL A 1 60  ? 174.31059 312.95906 6.54001   1.000 71.09003  ? 56  VAL F O   1 
ATOM   241  C CB  . VAL A 1 60  ? 177.39052 312.76793 6.62415   1.000 68.92480  ? 56  VAL F CB  1 
ATOM   242  C CG1 . VAL A 1 60  ? 177.52887 312.69272 5.12659   1.000 69.85683  ? 56  VAL F CG1 1 
ATOM   243  C CG2 . VAL A 1 60  ? 178.73677 312.95698 7.28438   1.000 68.41019  ? 56  VAL F CG2 1 
ATOM   244  N N   . ILE A 1 61  ? 174.94781 314.72177 5.27443   1.000 60.92312  ? 57  ILE F N   1 
ATOM   245  C CA  . ILE A 1 61  ? 173.76575 314.76892 4.41701   1.000 61.63494  ? 57  ILE F CA  1 
ATOM   246  C C   . ILE A 1 61  ? 174.18479 314.44276 2.98640   1.000 63.85530  ? 57  ILE F C   1 
ATOM   247  O O   . ILE A 1 61  ? 175.09391 315.08897 2.43798   1.000 59.02946  ? 57  ILE F O   1 
ATOM   248  C CB  . ILE A 1 61  ? 173.06166 316.13485 4.48513   1.000 59.79862  ? 57  ILE F CB  1 
ATOM   249  C CG1 . ILE A 1 61  ? 172.88483 316.59074 5.93933   1.000 61.59286  ? 57  ILE F CG1 1 
ATOM   250  C CG2 . ILE A 1 61  ? 171.74149 316.11002 3.74356   1.000 57.66163  ? 57  ILE F CG2 1 
ATOM   251  C CD1 . ILE A 1 61  ? 172.04607 315.66312 6.78897   1.000 65.28440  ? 57  ILE F CD1 1 
ATOM   252  N N   . THR A 1 62  ? 173.63474 313.35183 2.44196   1.000 61.64500  ? 58  THR F N   1 
ATOM   253  C CA  . THR A 1 62  ? 173.95408 312.86618 1.10030   1.000 66.60549  ? 58  THR F CA  1 
ATOM   254  C C   . THR A 1 62  ? 172.78931 313.05308 0.12689   1.000 66.27049  ? 58  THR F C   1 
ATOM   255  O O   . THR A 1 62  ? 171.61468 312.94899 0.49685   1.000 66.45877  ? 58  THR F O   1 
ATOM   256  C CB  . THR A 1 62  ? 174.31935 311.37998 1.12328   1.000 66.99176  ? 58  THR F CB  1 
ATOM   257  O OG1 . THR A 1 62  ? 173.13835 310.62371 1.44130   1.000 73.78699  ? 58  THR F OG1 1 
ATOM   258  C CG2 . THR A 1 62  ? 175.45415 311.07627 2.11513   1.000 69.47859  ? 58  THR F CG2 1 
ATOM   259  N N   . ILE A 1 63  ? 173.13372 313.28108 -1.13469  1.000 64.15224  ? 59  ILE F N   1 
ATOM   260  C CA  . ILE A 1 63  ? 172.18167 313.32461 -2.23952  1.000 71.60810  ? 59  ILE F CA  1 
ATOM   261  C C   . ILE A 1 63  ? 172.71727 312.42513 -3.35022  1.000 68.77849  ? 59  ILE F C   1 
ATOM   262  O O   . ILE A 1 63  ? 173.74617 312.74637 -3.95696  1.000 67.86447  ? 59  ILE F O   1 
ATOM   263  C CB  . ILE A 1 63  ? 171.96879 314.75662 -2.76538  1.000 67.09367  ? 59  ILE F CB  1 
ATOM   264  C CG1 . ILE A 1 63  ? 171.21331 315.61076 -1.74414  1.000 64.21780  ? 59  ILE F CG1 1 
ATOM   265  C CG2 . ILE A 1 63  ? 171.27602 314.73807 -4.12204  1.000 69.14831  ? 59  ILE F CG2 1 
ATOM   266  C CD1 . ILE A 1 63  ? 170.92972 317.00498 -2.25401  1.000 52.28687  ? 59  ILE F CD1 1 
ATOM   267  N N   . GLU A 1 64  ? 171.99680 311.33914 -3.65540  1.000 76.56764  ? 60  GLU F N   1 
ATOM   268  C CA  . GLU A 1 64  ? 172.43065 310.38635 -4.68271  1.000 74.63727  ? 60  GLU F CA  1 
ATOM   269  C C   . GLU A 1 64  ? 172.25968 310.98342 -6.06825  1.000 65.34369  ? 60  GLU F C   1 
ATOM   270  O O   . GLU A 1 64  ? 171.15230 311.36271 -6.45482  1.000 69.88438  ? 60  GLU F O   1 
ATOM   271  C CB  . GLU A 1 64  ? 171.72711 309.03805 -4.60374  1.000 79.13936  ? 60  GLU F CB  1 
ATOM   272  C CG  . GLU A 1 64  ? 172.62643 307.92933 -4.04865  1.000 89.73743  ? 60  GLU F CG  1 
ATOM   273  C CD  . GLU A 1 64  ? 171.85337 306.66073 -3.73974  1.000 95.81907  ? 60  GLU F CD  1 
ATOM   274  O OE1 . GLU A 1 64  ? 171.03275 306.24968 -4.58510  1.000 97.86054  ? 60  GLU F OE1 1 
ATOM   275  O OE2 . GLU A 1 64  ? 172.10846 306.04730 -2.67712  1.000 102.28044 ? 60  GLU F OE2 1 
ATOM   276  N N   . LEU A 1 65  ? 173.36399 311.17337 -6.76567  1.000 65.20124  ? 61  LEU F N   1 
ATOM   277  C CA  . LEU A 1 65  ? 173.35645 311.78317 -8.08242  1.000 67.11225  ? 61  LEU F CA  1 
ATOM   278  C C   . LEU A 1 65  ? 173.52399 310.72084 -9.16483  1.000 80.67045  ? 61  LEU F C   1 
ATOM   279  O O   . LEU A 1 65  ? 173.87319 309.56824 -8.90300  1.000 80.78652  ? 61  LEU F O   1 
ATOM   280  C CB  . LEU A 1 65  ? 174.48174 312.80513 -8.19346  1.000 71.16606  ? 61  LEU F CB  1 
ATOM   281  C CG  . LEU A 1 65  ? 174.30857 314.00398 -7.26192  1.000 75.47915  ? 61  LEU F CG  1 
ATOM   282  C CD1 . LEU A 1 65  ? 175.40446 315.01752 -7.52048  1.000 74.79008  ? 61  LEU F CD1 1 
ATOM   283  C CD2 . LEU A 1 65  ? 172.92920 314.61715 -7.40014  1.000 69.26853  ? 61  LEU F CD2 1 
ATOM   284  N N   . SER A 1 66  ? 173.27964 311.13079 -10.40317 1.000 74.14535  ? 62  SER F N   1 
ATOM   285  C CA  . SER A 1 66  ? 173.36886 310.24844 -11.55473 1.000 79.28566  ? 62  SER F CA  1 
ATOM   286  C C   . SER A 1 66  ? 174.55628 310.65119 -12.40878 1.000 81.61062  ? 62  SER F C   1 
ATOM   287  O O   . SER A 1 66  ? 174.59835 311.77644 -12.92272 1.000 75.34291  ? 62  SER F O   1 
ATOM   288  C CB  . SER A 1 66  ? 172.08680 310.32262 -12.38773 1.000 81.74906  ? 62  SER F CB  1 
ATOM   289  O OG  . SER A 1 66  ? 172.11938 309.41011 -13.47100 1.000 82.51330  ? 62  SER F OG  1 
ATOM   290  N N   . ASN A 1 67  ? 175.51113 309.73237 -12.57323 1.000 90.71476  ? 63  ASN F N   1 
ATOM   291  C CA  . ASN A 1 67  ? 176.65949 310.03088 -13.42384 1.000 93.43797  ? 63  ASN F CA  1 
ATOM   292  C C   . ASN A 1 67  ? 176.10888 309.77947 -14.81959 1.000 95.59269  ? 63  ASN F C   1 
ATOM   293  O O   . ASN A 1 67  ? 176.14276 308.66332 -15.34430 1.000 98.83776  ? 63  ASN F O   1 
ATOM   294  C CB  . ASN A 1 67  ? 177.87305 309.17779 -13.07398 1.000 94.34219  ? 63  ASN F CB  1 
ATOM   295  C CG  . ASN A 1 67  ? 179.15950 309.70366 -13.71661 1.000 103.91611 ? 63  ASN F CG  1 
ATOM   296  O OD1 . ASN A 1 67  ? 179.14952 310.72638 -14.41089 1.000 102.84775 ? 63  ASN F OD1 1 
ATOM   297  N ND2 . ASN A 1 67  ? 180.27742 309.03161 -13.44875 1.000 102.59841 ? 63  ASN F ND2 1 
ATOM   298  N N   . ILE A 1 68  ? 175.58815 310.85040 -15.41739 1.000 94.60906  ? 64  ILE F N   1 
ATOM   299  C CA  . ILE A 1 68  ? 174.97631 310.83116 -16.74158 1.000 95.05895  ? 64  ILE F CA  1 
ATOM   300  C C   . ILE A 1 68  ? 175.57145 311.93115 -17.60476 1.000 102.00729 ? 64  ILE F C   1 
ATOM   301  O O   . ILE A 1 68  ? 175.16675 313.09538 -17.51254 1.000 100.75426 ? 64  ILE F O   1 
ATOM   302  C CB  . ILE A 1 68  ? 173.44938 310.98021 -16.66262 1.000 88.19052  ? 64  ILE F CB  1 
ATOM   303  C CG1 . ILE A 1 68  ? 172.87081 311.46933 -17.99163 1.000 89.75551  ? 64  ILE F CG1 1 
ATOM   304  C CG2 . ILE A 1 68  ? 173.03012 311.87977 -15.52530 1.000 84.98905  ? 64  ILE F CG2 1 
ATOM   305  C CD1 . ILE A 1 68  ? 171.44109 311.03764 -18.21376 1.000 82.73391  ? 64  ILE F CD1 1 
ATOM   306  N N   . LYS A 1 69  ? 176.53282 311.56121 -18.44167 1.000 111.15417 ? 65  LYS F N   1 
ATOM   307  C CA  . LYS A 1 69  ? 177.10772 312.45113 -19.43443 1.000 114.06843 ? 65  LYS F CA  1 
ATOM   308  C C   . LYS A 1 69  ? 176.00438 312.82034 -20.42042 1.000 114.92958 ? 65  LYS F C   1 
ATOM   309  O O   . LYS A 1 69  ? 174.94560 312.17476 -20.44381 1.000 111.20761 ? 65  LYS F O   1 
ATOM   310  C CB  . LYS A 1 69  ? 178.26941 311.76294 -20.15880 1.000 113.10259 ? 65  LYS F CB  1 
ATOM   311  C CG  . LYS A 1 69  ? 179.43439 311.34992 -19.25458 1.000 108.19953 ? 65  LYS F CG  1 
ATOM   312  C CD  . LYS A 1 69  ? 180.00076 312.53123 -18.47834 1.000 109.10162 ? 65  LYS F CD  1 
ATOM   313  C CE  . LYS A 1 69  ? 181.20744 312.12071 -17.65126 1.000 107.83156 ? 65  LYS F CE  1 
ATOM   314  N NZ  . LYS A 1 69  ? 180.86082 311.04707 -16.68425 1.000 107.44107 ? 65  LYS F NZ  1 
ATOM   315  N N   . GLU A 1 70  ? 176.22347 313.86763 -21.23217 1.000 121.14882 ? 66  GLU F N   1 
ATOM   316  C CA  . GLU A 1 70  ? 175.11616 314.26803 -22.08776 1.000 122.39648 ? 66  GLU F CA  1 
ATOM   317  C C   . GLU A 1 70  ? 174.87851 313.07005 -22.98052 1.000 122.39301 ? 66  GLU F C   1 
ATOM   318  O O   . GLU A 1 70  ? 175.81695 312.49862 -23.54299 1.000 121.53707 ? 66  GLU F O   1 
ATOM   319  C CB  . GLU A 1 70  ? 175.44436 315.49292 -22.95229 1.000 120.17276 ? 66  GLU F CB  1 
ATOM   320  C CG  . GLU A 1 70  ? 175.52795 316.83289 -22.25003 1.000 118.98880 ? 66  GLU F CG  1 
ATOM   321  C CD  . GLU A 1 70  ? 176.02918 317.92564 -23.18617 1.000 117.04142 ? 66  GLU F CD  1 
ATOM   322  O OE1 . GLU A 1 70  ? 176.39726 317.60155 -24.33882 1.000 117.92143 ? 66  GLU F OE1 1 
ATOM   323  O OE2 . GLU A 1 70  ? 176.05151 319.10477 -22.77447 1.000 113.96389 ? 66  GLU F OE2 1 
ATOM   324  N N   . ASN A 1 71  ? 173.62083 312.71609 -23.16507 1.000 122.53011 ? 67  ASN F N   1 
ATOM   325  C CA  . ASN A 1 71  ? 173.39224 311.57011 -24.02034 1.000 123.86894 ? 67  ASN F CA  1 
ATOM   326  C C   . ASN A 1 71  ? 172.35404 311.91832 -25.08945 1.000 127.79017 ? 67  ASN F C   1 
ATOM   327  O O   . ASN A 1 71  ? 171.62071 311.05730 -25.58145 1.000 129.74120 ? 67  ASN F O   1 
ATOM   328  C CB  . ASN A 1 71  ? 173.03673 310.37948 -23.11821 1.000 121.58196 ? 67  ASN F CB  1 
ATOM   329  C CG  . ASN A 1 71  ? 173.13454 309.04347 -23.81413 1.000 127.38088 ? 67  ASN F CG  1 
ATOM   330  O OD1 . ASN A 1 71  ? 172.70591 308.88233 -24.94826 1.000 131.03455 ? 67  ASN F OD1 1 
ATOM   331  N ND2 . ASN A 1 71  ? 173.77194 308.08044 -23.13809 1.000 124.16836 ? 67  ASN F ND2 1 
ATOM   332  N N   . LYS A 1 72  ? 172.31565 313.21097 -25.43705 1.000 126.63002 ? 68  LYS F N   1 
ATOM   333  C CA  . LYS A 1 72  ? 171.47391 313.89022 -26.42536 1.000 129.50973 ? 68  LYS F CA  1 
ATOM   334  C C   . LYS A 1 72  ? 171.10855 313.00183 -27.61693 1.000 131.84280 ? 68  LYS F C   1 
ATOM   335  O O   . LYS A 1 72  ? 171.99027 312.41384 -28.25103 1.000 127.46466 ? 68  LYS F O   1 
ATOM   336  C CB  . LYS A 1 72  ? 172.14600 315.19995 -26.85254 1.000 128.15286 ? 68  LYS F CB  1 
ATOM   337  C CG  . LYS A 1 72  ? 172.21309 316.19410 -25.67941 1.000 125.60143 ? 68  LYS F CG  1 
ATOM   338  C CD  . LYS A 1 72  ? 172.44697 317.63343 -26.11036 1.000 119.40293 ? 68  LYS F CD  1 
ATOM   339  C CE  . LYS A 1 72  ? 172.34460 318.57005 -24.91271 1.000 111.81360 ? 68  LYS F CE  1 
ATOM   340  N NZ  . LYS A 1 72  ? 172.61365 319.98410 -25.27945 1.000 107.39248 ? 68  LYS F NZ  1 
ATOM   341  N N   . CYS A 1 73  ? 169.81099 312.90577 -27.92687 1.000 133.74005 ? 69  CYS F N   1 
ATOM   342  C CA  . CYS A 1 73  ? 169.29370 312.15074 -29.06734 1.000 135.33450 ? 69  CYS F CA  1 
ATOM   343  C C   . CYS A 1 73  ? 168.31135 313.00190 -29.87117 1.000 136.46084 ? 69  CYS F C   1 
ATOM   344  O O   . CYS A 1 73  ? 167.96115 314.12094 -29.48048 1.000 130.16135 ? 69  CYS F O   1 
ATOM   345  C CB  . CYS A 1 73  ? 168.57812 310.86287 -28.61014 1.000 133.80725 ? 69  CYS F CB  1 
ATOM   346  S SG  . CYS A 1 73  ? 167.52307 311.00951 -27.09340 1.000 143.01820 ? 69  CYS F SG  1 
ATOM   347  N N   . ASN A 1 74  ? 167.90105 312.47447 -31.03992 1.000 140.08062 ? 70  ASN F N   1 
ATOM   348  C CA  . ASN A 1 74  ? 166.91070 313.15029 -31.87975 1.000 137.02368 ? 70  ASN F CA  1 
ATOM   349  C C   . ASN A 1 74  ? 165.65896 313.38901 -31.03873 1.000 132.00074 ? 70  ASN F C   1 
ATOM   350  O O   . ASN A 1 74  ? 164.88042 312.47138 -30.75413 1.000 132.51681 ? 70  ASN F O   1 
ATOM   351  C CB  . ASN A 1 74  ? 166.59700 312.30360 -33.12763 1.000 134.64827 ? 70  ASN F CB  1 
ATOM   352  C CG  . ASN A 1 74  ? 167.68629 312.39081 -34.20756 1.000 135.91509 ? 70  ASN F CG  1 
ATOM   353  O OD1 . ASN A 1 74  ? 168.52662 313.29415 -34.19995 1.000 137.14983 ? 70  ASN F OD1 1 
ATOM   354  N ND2 . ASN A 1 74  ? 167.68197 311.42702 -35.12730 1.000 132.87245 ? 70  ASN F ND2 1 
ATOM   355  N N   . GLY A 1 75  ? 165.46230 314.65326 -30.69465 1.000 125.92091 ? 71  GLY F N   1 
ATOM   356  C CA  . GLY A 1 75  ? 164.33287 315.07352 -29.87741 1.000 119.54739 ? 71  GLY F CA  1 
ATOM   357  C C   . GLY A 1 75  ? 163.62548 316.28591 -30.43957 1.000 112.74581 ? 71  GLY F C   1 
ATOM   358  O O   . GLY A 1 75  ? 164.26333 317.20414 -30.95453 1.000 115.82037 ? 71  GLY F O   1 
ATOM   359  N N   . THR A 1 76  ? 162.29362 316.26120 -30.38085 1.000 103.54917 ? 72  THR F N   1 
ATOM   360  C CA  . THR A 1 76  ? 161.51301 317.36492 -30.93267 1.000 102.88847 ? 72  THR F CA  1 
ATOM   361  C C   . THR A 1 76  ? 160.28517 317.69248 -30.08078 1.000 101.27916 ? 72  THR F C   1 
ATOM   362  O O   . THR A 1 76  ? 160.11194 318.86006 -29.72447 1.000 108.23214 ? 72  THR F O   1 
ATOM   363  C CB  . THR A 1 76  ? 161.13109 317.16566 -32.39372 1.000 107.81673 ? 72  THR F CB  1 
ATOM   364  O OG1 . THR A 1 76  ? 161.66312 318.27371 -33.13155 1.000 104.07101 ? 72  THR F OG1 1 
ATOM   365  C CG2 . THR A 1 76  ? 159.63621 317.26572 -32.55229 1.000 104.67256 ? 72  THR F CG2 1 
ATOM   366  N N   . ASP A 1 77  ? 159.41512 316.73100 -29.74869 1.000 103.29042 ? 73  ASP F N   1 
ATOM   367  C CA  . ASP A 1 77  ? 158.18665 317.10227 -29.04144 1.000 105.53308 ? 73  ASP F CA  1 
ATOM   368  C C   . ASP A 1 77  ? 158.49796 317.79532 -27.72253 1.000 101.77819 ? 73  ASP F C   1 
ATOM   369  O O   . ASP A 1 77  ? 159.51940 317.54021 -27.07550 1.000 103.20781 ? 73  ASP F O   1 
ATOM   370  C CB  . ASP A 1 77  ? 157.33735 315.86020 -28.72710 1.000 108.74542 ? 73  ASP F CB  1 
ATOM   371  C CG  . ASP A 1 77  ? 156.28560 316.12490 -27.63185 1.000 112.03051 ? 73  ASP F CG  1 
ATOM   372  O OD1 . ASP A 1 77  ? 155.59563 317.17042 -27.69679 1.000 114.21709 ? 73  ASP F OD1 1 
ATOM   373  O OD2 . ASP A 1 77  ? 156.16376 315.29902 -26.69702 1.000 110.54260 ? 73  ASP F OD2 1 
ATOM   374  N N   . ALA A 1 78  ? 157.58372 318.69969 -27.34119 1.000 101.97829 ? 74  ALA F N   1 
ATOM   375  C CA  . ALA A 1 78  ? 157.87793 319.67308 -26.29516 1.000 97.17274  ? 74  ALA F CA  1 
ATOM   376  C C   . ALA A 1 78  ? 158.21424 319.02248 -24.96201 1.000 94.76701  ? 74  ALA F C   1 
ATOM   377  O O   . ALA A 1 78  ? 159.00658 319.58400 -24.19422 1.000 94.98301  ? 74  ALA F O   1 
ATOM   378  C CB  . ALA A 1 78  ? 156.69044 320.62576 -26.14810 1.000 96.00250  ? 74  ALA F CB  1 
ATOM   379  N N   . LYS A 1 79  ? 157.70381 317.81287 -24.70515 1.000 93.47663  ? 75  LYS F N   1 
ATOM   380  C CA  . LYS A 1 79  ? 157.97407 317.18075 -23.42370 1.000 89.51413  ? 75  LYS F CA  1 
ATOM   381  C C   . LYS A 1 79  ? 159.44668 316.81167 -23.33805 1.000 90.39221  ? 75  LYS F C   1 
ATOM   382  O O   . LYS A 1 79  ? 160.08972 316.95927 -22.28723 1.000 91.20544  ? 75  LYS F O   1 
ATOM   383  C CB  . LYS A 1 79  ? 157.12115 315.91672 -23.25197 1.000 95.49912  ? 75  LYS F CB  1 
ATOM   384  C CG  . LYS A 1 79  ? 155.65786 316.08535 -22.84216 1.000 95.54546  ? 75  LYS F CG  1 
ATOM   385  C CD  . LYS A 1 79  ? 154.88818 314.85714 -23.38060 1.000 97.77240  ? 75  LYS F CD  1 
ATOM   386  C CE  . LYS A 1 79  ? 153.55728 315.16014 -24.05139 1.000 101.62347 ? 75  LYS F CE  1 
ATOM   387  N NZ  . LYS A 1 79  ? 152.52732 315.64671 -23.08330 1.000 101.05883 ? 75  LYS F NZ  1 
ATOM   388  N N   . VAL A 1 80  ? 160.00765 316.40093 -24.47313 1.000 92.58574  ? 76  VAL F N   1 
ATOM   389  C CA  . VAL A 1 80  ? 161.42581 316.07597 -24.57365 1.000 88.99634  ? 76  VAL F CA  1 
ATOM   390  C C   . VAL A 1 80  ? 162.27386 317.32595 -24.40528 1.000 86.12072  ? 76  VAL F C   1 
ATOM   391  O O   . VAL A 1 80  ? 163.34087 317.29035 -23.77450 1.000 80.78758  ? 76  VAL F O   1 
ATOM   392  C CB  . VAL A 1 80  ? 161.69532 315.38915 -25.91433 1.000 94.30203  ? 76  VAL F CB  1 
ATOM   393  C CG1 . VAL A 1 80  ? 163.02067 314.65767 -25.89473 1.000 89.88081  ? 76  VAL F CG1 1 
ATOM   394  C CG2 . VAL A 1 80  ? 160.54541 314.42507 -26.24267 1.000 99.84041  ? 76  VAL F CG2 1 
ATOM   395  N N   . LYS A 1 81  ? 161.83707 318.44686 -24.99088 1.000 88.39673  ? 77  LYS F N   1 
ATOM   396  C CA  . LYS A 1 81  ? 162.58127 319.69498 -24.80511 1.000 91.11530  ? 77  LYS F CA  1 
ATOM   397  C C   . LYS A 1 81  ? 162.60362 320.09871 -23.34083 1.000 90.81683  ? 77  LYS F C   1 
ATOM   398  O O   . LYS A 1 81  ? 163.63995 320.52381 -22.81283 1.000 88.41865  ? 77  LYS F O   1 
ATOM   399  C CB  . LYS A 1 81  ? 161.97549 320.80947 -25.65060 1.000 91.56582  ? 77  LYS F CB  1 
ATOM   400  C CG  . LYS A 1 81  ? 162.97782 321.84642 -26.09412 1.000 95.66484  ? 77  LYS F CG  1 
ATOM   401  C CD  . LYS A 1 81  ? 162.20938 322.94772 -26.74966 1.000 99.25763  ? 77  LYS F CD  1 
ATOM   402  C CE  . LYS A 1 81  ? 160.99345 323.27353 -25.90431 1.000 100.39065 ? 77  LYS F CE  1 
ATOM   403  N NZ  . LYS A 1 81  ? 160.08077 324.23858 -26.58138 1.000 101.59008 ? 77  LYS F NZ  1 
ATOM   404  N N   . LEU A 1 82  ? 161.46704 319.97343 -22.66882 1.000 89.53031  ? 78  LEU F N   1 
ATOM   405  C CA  . LEU A 1 82  ? 161.39658 320.36195 -21.26875 1.000 83.92221  ? 78  LEU F CA  1 
ATOM   406  C C   . LEU A 1 82  ? 162.32383 319.47638 -20.43636 1.000 79.40773  ? 78  LEU F C   1 
ATOM   407  O O   . LEU A 1 82  ? 163.03813 319.96069 -19.54701 1.000 81.33010  ? 78  LEU F O   1 
ATOM   408  C CB  . LEU A 1 82  ? 159.94200 320.24191 -20.81037 1.000 84.10156  ? 78  LEU F CB  1 
ATOM   409  C CG  . LEU A 1 82  ? 159.02081 321.31855 -21.40300 1.000 80.39223  ? 78  LEU F CG  1 
ATOM   410  C CD1 . LEU A 1 82  ? 157.55734 321.02256 -21.16161 1.000 82.09751  ? 78  LEU F CD1 1 
ATOM   411  C CD2 . LEU A 1 82  ? 159.36282 322.67951 -20.82533 1.000 79.43414  ? 78  LEU F CD2 1 
ATOM   412  N N   . ILE A 1 83  ? 162.35423 318.17409 -20.74372 1.000 76.03730  ? 79  ILE F N   1 
ATOM   413  C CA  . ILE A 1 83  ? 163.23752 317.24292 -20.03630 1.000 73.68310  ? 79  ILE F CA  1 
ATOM   414  C C   . ILE A 1 83  ? 164.70550 317.57794 -20.28612 1.000 77.63168  ? 79  ILE F C   1 
ATOM   415  O O   . ILE A 1 83  ? 165.52907 317.55956 -19.36779 1.000 79.91800  ? 79  ILE F O   1 
ATOM   416  C CB  . ILE A 1 83  ? 162.93464 315.78977 -20.42894 1.000 76.13444  ? 79  ILE F CB  1 
ATOM   417  C CG1 . ILE A 1 83  ? 161.73282 315.30657 -19.63688 1.000 75.38185  ? 79  ILE F CG1 1 
ATOM   418  C CG2 . ILE A 1 83  ? 164.12588 314.90145 -20.09934 1.000 76.37280  ? 79  ILE F CG2 1 
ATOM   419  C CD1 . ILE A 1 83  ? 161.98305 315.30037 -18.16981 1.000 80.37749  ? 79  ILE F CD1 1 
ATOM   420  N N   . LYS A 1 84  ? 165.06990 317.82200 -21.54312 1.000 79.29148  ? 80  LYS F N   1 
ATOM   421  C CA  . LYS A 1 84  ? 166.46083 318.13001 -21.85822 1.000 79.52442  ? 80  LYS F CA  1 
ATOM   422  C C   . LYS A 1 84  ? 166.91059 319.44350 -21.22442 1.000 79.31072  ? 80  LYS F C   1 
ATOM   423  O O   . LYS A 1 84  ? 168.04753 319.55800 -20.74656 1.000 77.45777  ? 80  LYS F O   1 
ATOM   424  C CB  . LYS A 1 84  ? 166.59794 318.21596 -23.37921 1.000 82.25606  ? 80  LYS F CB  1 
ATOM   425  C CG  . LYS A 1 84  ? 166.24718 316.92296 -24.11486 1.000 86.32721  ? 80  LYS F CG  1 
ATOM   426  C CD  . LYS A 1 84  ? 167.15742 316.60255 -25.27741 1.000 87.54947  ? 80  LYS F CD  1 
ATOM   427  C CE  . LYS A 1 84  ? 166.32842 316.00709 -26.40884 1.000 98.97417  ? 80  LYS F CE  1 
ATOM   428  N NZ  . LYS A 1 84  ? 167.08440 314.99648 -27.19500 1.000 118.13252 ? 80  LYS F NZ  1 
ATOM   429  N N   . GLN A 1 85  ? 166.00667 320.41051 -21.12017 1.000 84.85043  ? 81  GLN F N   1 
ATOM   430  C CA  . GLN A 1 85  ? 166.32445 321.66481 -20.44614 1.000 80.58713  ? 81  GLN F CA  1 
ATOM   431  C C   . GLN A 1 85  ? 166.59106 321.44338 -18.96272 1.000 81.66261  ? 81  GLN F C   1 
ATOM   432  O O   . GLN A 1 85  ? 167.62220 321.88528 -18.41680 1.000 78.82647  ? 81  GLN F O   1 
ATOM   433  C CB  . GLN A 1 85  ? 165.17059 322.64684 -20.64934 1.000 85.95050  ? 81  GLN F CB  1 
ATOM   434  C CG  . GLN A 1 85  ? 165.12138 323.29820 -22.02810 1.000 89.70410  ? 81  GLN F CG  1 
ATOM   435  C CD  . GLN A 1 85  ? 164.04711 324.38004 -22.11311 1.000 98.57236  ? 81  GLN F CD  1 
ATOM   436  O OE1 . GLN A 1 85  ? 163.44668 324.74554 -21.09925 1.000 100.01371 ? 81  GLN F OE1 1 
ATOM   437  N NE2 . GLN A 1 85  ? 163.71884 324.81296 -23.33752 1.000 99.78110  ? 81  GLN F NE2 1 
ATOM   438  N N   . GLU A 1 86  ? 165.68200 320.72642 -18.29707 1.000 75.76604  ? 82  GLU F N   1 
ATOM   439  C CA  . GLU A 1 86  ? 165.89970 320.45096 -16.88529 1.000 75.05895  ? 82  GLU F CA  1 
ATOM   440  C C   . GLU A 1 86  ? 167.14041 319.57725 -16.67794 1.000 72.37534  ? 82  GLU F C   1 
ATOM   441  O O   . GLU A 1 86  ? 167.83473 319.69750 -15.65786 1.000 75.80581  ? 82  GLU F O   1 
ATOM   442  C CB  . GLU A 1 86  ? 164.64388 319.79740 -16.30564 1.000 73.66444  ? 82  GLU F CB  1 
ATOM   443  C CG  . GLU A 1 86  ? 164.65182 319.65233 -14.80862 1.000 74.43160  ? 82  GLU F CG  1 
ATOM   444  C CD  . GLU A 1 86  ? 164.57526 321.04808 -14.16616 1.000 79.81772  ? 82  GLU F CD  1 
ATOM   445  O OE1 . GLU A 1 86  ? 164.08409 321.95939 -14.86692 1.000 80.35981  ? 82  GLU F OE1 1 
ATOM   446  O OE2 . GLU A 1 86  ? 164.97305 321.23364 -12.98209 1.000 80.80607  ? 82  GLU F OE2 1 
ATOM   447  N N   . LEU A 1 87  ? 167.46499 318.72140 -17.64418 1.000 73.34851  ? 83  LEU F N   1 
ATOM   448  C CA  . LEU A 1 87  ? 168.66607 317.90464 -17.52034 1.000 73.68394  ? 83  LEU F CA  1 
ATOM   449  C C   . LEU A 1 87  ? 169.93159 318.73930 -17.64703 1.000 74.26717  ? 83  LEU F C   1 
ATOM   450  O O   . LEU A 1 87  ? 170.93899 318.43747 -16.99279 1.000 77.49772  ? 83  LEU F O   1 
ATOM   451  C CB  . LEU A 1 87  ? 168.64213 316.78977 -18.56813 1.000 73.38457  ? 83  LEU F CB  1 
ATOM   452  C CG  . LEU A 1 87  ? 168.20053 315.46591 -17.94655 1.000 74.73358  ? 83  LEU F CG  1 
ATOM   453  C CD1 . LEU A 1 87  ? 167.63470 314.50165 -18.98359 1.000 71.05467  ? 83  LEU F CD1 1 
ATOM   454  C CD2 . LEU A 1 87  ? 169.37092 314.85595 -17.19504 1.000 69.89907  ? 83  LEU F CD2 1 
ATOM   455  N N   . ASP A 1 88  ? 169.90890 319.79500 -18.47072 1.000 74.48255  ? 84  ASP F N   1 
ATOM   456  C CA  . ASP A 1 88  ? 171.09394 320.64971 -18.52322 1.000 78.88500  ? 84  ASP F CA  1 
ATOM   457  C C   . ASP A 1 88  ? 171.23806 321.45190 -17.24144 1.000 76.60411  ? 84  ASP F C   1 
ATOM   458  O O   . ASP A 1 88  ? 172.36004 321.68663 -16.77868 1.000 72.10989  ? 84  ASP F O   1 
ATOM   459  C CB  . ASP A 1 88  ? 171.07135 321.60318 -19.72444 1.000 81.40813  ? 84  ASP F CB  1 
ATOM   460  C CG  . ASP A 1 88  ? 171.29829 320.89397 -21.05052 1.000 89.67826  ? 84  ASP F CG  1 
ATOM   461  O OD1 . ASP A 1 88  ? 170.63011 321.28077 -22.02983 1.000 86.78088  ? 84  ASP F OD1 1 
ATOM   462  O OD2 . ASP A 1 88  ? 172.17707 319.99417 -21.12718 1.000 93.02388  ? 84  ASP F OD2 1 
ATOM   463  N N   . LYS A 1 89  ? 170.11920 321.86101 -16.64550 1.000 73.10010  ? 85  LYS F N   1 
ATOM   464  C CA  . LYS A 1 89  ? 170.23455 322.52153 -15.35427 1.000 69.81747  ? 85  LYS F CA  1 
ATOM   465  C C   . LYS A 1 89  ? 170.78059 321.56734 -14.29415 1.000 73.48395  ? 85  LYS F C   1 
ATOM   466  O O   . LYS A 1 89  ? 171.58876 321.97562 -13.43890 1.000 71.59860  ? 85  LYS F O   1 
ATOM   467  C CB  . LYS A 1 89  ? 168.86821 323.03197 -14.90103 1.000 66.68948  ? 85  LYS F CB  1 
ATOM   468  C CG  . LYS A 1 89  ? 168.32329 324.28871 -15.57044 1.000 68.57994  ? 85  LYS F CG  1 
ATOM   469  C CD  . LYS A 1 89  ? 167.09147 324.72190 -14.77437 1.000 67.10562  ? 85  LYS F CD  1 
ATOM   470  C CE  . LYS A 1 89  ? 165.84615 324.81419 -15.62279 1.000 75.00993  ? 85  LYS F CE  1 
ATOM   471  N NZ  . LYS A 1 89  ? 164.65202 325.27805 -14.83771 1.000 72.38597  ? 85  LYS F NZ  1 
ATOM   472  N N   . TYR A 1 90  ? 170.48347 320.27027 -14.42427 1.000 71.73462  ? 86  TYR F N   1 
ATOM   473  C CA  . TYR A 1 90  ? 171.12707 319.31324 -13.53327 1.000 70.38033  ? 86  TYR F CA  1 
ATOM   474  C C   . TYR A 1 90  ? 172.62518 319.20415 -13.79537 1.000 69.26540  ? 86  TYR F C   1 
ATOM   475  O O   . TYR A 1 90  ? 173.42088 319.15104 -12.83990 1.000 69.21368  ? 86  TYR F O   1 
ATOM   476  C CB  . TYR A 1 90  ? 170.45330 317.94757 -13.72220 1.000 68.22217  ? 86  TYR F CB  1 
ATOM   477  C CG  . TYR A 1 90  ? 171.14706 316.77116 -13.07924 1.000 59.97134  ? 86  TYR F CG  1 
ATOM   478  C CD1 . TYR A 1 90  ? 170.92875 316.44678 -11.75443 1.000 53.77389  ? 86  TYR F CD1 1 
ATOM   479  C CD2 . TYR A 1 90  ? 172.05390 315.99680 -13.80954 1.000 66.13686  ? 86  TYR F CD2 1 
ATOM   480  C CE1 . TYR A 1 90  ? 171.57054 315.36687 -11.17144 1.000 60.32308  ? 86  TYR F CE1 1 
ATOM   481  C CE2 . TYR A 1 90  ? 172.71044 314.92636 -13.23743 1.000 57.96566  ? 86  TYR F CE2 1 
ATOM   482  C CZ  . TYR A 1 90  ? 172.46559 314.61411 -11.91717 1.000 63.76556  ? 86  TYR F CZ  1 
ATOM   483  O OH  . TYR A 1 90  ? 173.10815 313.53797 -11.34005 1.000 68.69914  ? 86  TYR F OH  1 
ATOM   484  N N   . LYS A 1 91  ? 173.05534 319.23125 -15.06170 1.000 65.98859  ? 87  LYS F N   1 
ATOM   485  C CA  . LYS A 1 91  ? 174.49827 319.08973 -15.23042 1.000 73.56497  ? 87  LYS F CA  1 
ATOM   486  C C   . LYS A 1 91  ? 175.23196 320.34612 -14.79099 1.000 70.86626  ? 87  LYS F C   1 
ATOM   487  O O   . LYS A 1 91  ? 176.34562 320.25984 -14.25699 1.000 69.56987  ? 87  LYS F O   1 
ATOM   488  C CB  . LYS A 1 91  ? 174.96608 318.67849 -16.63010 1.000 76.80295  ? 87  LYS F CB  1 
ATOM   489  C CG  . LYS A 1 91  ? 174.59314 317.27734 -17.06218 1.000 83.95843  ? 87  LYS F CG  1 
ATOM   490  C CD  . LYS A 1 91  ? 174.92093 317.09458 -18.52707 1.000 95.47133  ? 87  LYS F CD  1 
ATOM   491  C CE  . LYS A 1 91  ? 175.83520 315.85355 -18.65073 1.000 106.19743 ? 87  LYS F CE  1 
ATOM   492  N NZ  . LYS A 1 91  ? 177.31669 316.14636 -18.68658 1.000 104.72569 ? 87  LYS F NZ  1 
ATOM   493  N N   . ASN A 1 92  ? 174.66441 321.52243 -15.05259 1.000 67.14665  ? 88  ASN F N   1 
ATOM   494  C CA  A ASN A 1 92  ? 175.35089 322.73249 -14.64159 0.713 68.91863  ? 88  ASN F CA  1 
ATOM   495  C CA  B ASN A 1 92  ? 175.33543 322.74683 -14.63533 0.287 70.48447  ? 88  ASN F CA  1 
ATOM   496  C C   . ASN A 1 92  ? 175.46336 322.79435 -13.12034 1.000 69.61875  ? 88  ASN F C   1 
ATOM   497  O O   . ASN A 1 92  ? 176.52060 323.13807 -12.58817 1.000 71.07060  ? 88  ASN F O   1 
ATOM   498  C CB  A ASN A 1 92  ? 174.64664 323.95143 -15.23258 0.713 71.56843  ? 88  ASN F CB  1 
ATOM   499  C CB  B ASN A 1 92  ? 174.60910 323.98657 -15.17911 0.287 70.21945  ? 88  ASN F CB  1 
ATOM   500  C CG  A ASN A 1 92  ? 174.92870 324.10881 -16.71931 0.713 73.19157  ? 88  ASN F CG  1 
ATOM   501  C CG  B ASN A 1 92  ? 173.25668 324.24859 -14.51116 0.287 71.32329  ? 88  ASN F CG  1 
ATOM   502  O OD1 A ASN A 1 92  ? 175.99388 323.72341 -17.19736 0.713 80.54906  ? 88  ASN F OD1 1 
ATOM   503  O OD1 B ASN A 1 92  ? 173.09647 324.10877 -13.29665 0.287 68.15884  ? 88  ASN F OD1 1 
ATOM   504  N ND2 A ASN A 1 92  ? 173.97241 324.65959 -17.45825 0.713 71.24140  ? 88  ASN F ND2 1 
ATOM   505  N ND2 B ASN A 1 92  ? 172.28678 324.67862 -15.31237 0.287 69.71250  ? 88  ASN F ND2 1 
ATOM   506  N N   . ALA A 1 93  ? 174.41126 322.40999 -12.40168 1.000 64.61262  ? 89  ALA F N   1 
ATOM   507  C CA  . ALA A 1 93  ? 174.53314 322.36859 -10.94757 1.000 68.96783  ? 89  ALA F CA  1 
ATOM   508  C C   . ALA A 1 93  ? 175.61486 321.38276 -10.50052 1.000 69.39762  ? 89  ALA F C   1 
ATOM   509  O O   . ALA A 1 93  ? 176.37649 321.66569 -9.56265  1.000 70.34137  ? 89  ALA F O   1 
ATOM   510  C CB  . ALA A 1 93  ? 173.18627 322.01979 -10.30957 1.000 63.07106  ? 89  ALA F CB  1 
ATOM   511  N N   . VAL A 1 94  ? 175.75022 320.25063 -11.20040 1.000 70.46133  ? 90  VAL F N   1 
ATOM   512  C CA  . VAL A 1 94  ? 176.78322 319.28028 -10.82753 1.000 68.51192  ? 90  VAL F CA  1 
ATOM   513  C C   . VAL A 1 94  ? 178.19354 319.78950 -11.13199 1.000 70.39502  ? 90  VAL F C   1 
ATOM   514  O O   . VAL A 1 94  ? 179.11586 319.64678 -10.31293 1.000 70.43776  ? 90  VAL F O   1 
ATOM   515  C CB  . VAL A 1 94  ? 176.50913 317.95031 -11.54981 1.000 73.25748  ? 90  VAL F CB  1 
ATOM   516  C CG1 . VAL A 1 94  ? 177.62130 316.94946 -11.27218 1.000 59.48233  ? 90  VAL F CG1 1 
ATOM   517  C CG2 . VAL A 1 94  ? 175.14069 317.39671 -11.14358 1.000 70.10227  ? 90  VAL F CG2 1 
ATOM   518  N N   . THR A 1 95  ? 178.39271 320.41831 -12.28376 1.000 68.91840  ? 91  THR F N   1 
ATOM   519  C CA  . THR A 1 95  ? 179.73602 320.90646 -12.55933 1.000 70.93300  ? 91  THR F CA  1 
ATOM   520  C C   . THR A 1 95  ? 180.07856 322.08089 -11.64927 1.000 70.67771  ? 91  THR F C   1 
ATOM   521  O O   . THR A 1 95  ? 181.24136 322.26649 -11.29005 1.000 70.44072  ? 91  THR F O   1 
ATOM   522  C CB  . THR A 1 95  ? 179.89135 321.30395 -14.02903 1.000 67.94285  ? 91  THR F CB  1 
ATOM   523  O OG1 . THR A 1 95  ? 178.98554 322.36386 -14.33001 1.000 79.34876  ? 91  THR F OG1 1 
ATOM   524  C CG2 . THR A 1 95  ? 179.59141 320.12823 -14.96472 1.000 70.03344  ? 91  THR F CG2 1 
ATOM   525  N N   . ASP A 1 96  ? 179.08144 322.87769 -11.26537 1.000 69.81631  ? 92  ASP F N   1 
ATOM   526  C CA  . ASP A 1 96  ? 179.31579 323.97896 -10.34099 1.000 71.51115  ? 92  ASP F CA  1 
ATOM   527  C C   . ASP A 1 96  ? 179.71587 323.47571 -8.96732  1.000 71.77079  ? 92  ASP F C   1 
ATOM   528  O O   . ASP A 1 96  ? 180.64124 324.01167 -8.34981  1.000 66.09321  ? 92  ASP F O   1 
ATOM   529  C CB  . ASP A 1 96  ? 178.08329 324.86062 -10.27276 1.000 67.54276  ? 92  ASP F CB  1 
ATOM   530  C CG  . ASP A 1 96  ? 177.95680 325.74299 -11.50025 1.000 84.48711  ? 92  ASP F CG  1 
ATOM   531  O OD1 . ASP A 1 96  ? 178.64162 325.43877 -12.51653 1.000 82.30969  ? 92  ASP F OD1 1 
ATOM   532  O OD2 . ASP A 1 96  ? 177.16730 326.71730 -11.46180 1.000 88.51315  ? 92  ASP F OD2 1 
ATOM   533  N N   . LEU A 1 97  ? 179.09258 322.39846 -8.49859  1.000 69.06603  ? 93  LEU F N   1 
ATOM   534  C CA  . LEU A 1 97  ? 179.54635 321.88236 -7.21722  1.000 68.08126  ? 93  LEU F CA  1 
ATOM   535  C C   . LEU A 1 97  ? 180.94731 321.31350 -7.35910  1.000 74.91716  ? 93  LEU F C   1 
ATOM   536  O O   . LEU A 1 97  ? 181.75994 321.39769 -6.41921  1.000 77.13380  ? 93  LEU F O   1 
ATOM   537  C CB  . LEU A 1 97  ? 178.57740 320.81206 -6.74047  1.000 68.44661  ? 93  LEU F CB  1 
ATOM   538  C CG  . LEU A 1 97  ? 177.21364 321.33283 -6.28926  1.000 72.42494  ? 93  LEU F CG  1 
ATOM   539  C CD1 . LEU A 1 97  ? 176.35217 320.16647 -5.83950  1.000 68.31123  ? 93  LEU F CD1 1 
ATOM   540  C CD2 . LEU A 1 97  ? 177.33300 322.37977 -5.18977  1.000 66.26853  ? 93  LEU F CD2 1 
ATOM   541  N N   . GLN A 1 98  ? 181.30451 320.90372 -8.57519  1.000 75.72542  ? 94  GLN F N   1 
ATOM   542  C CA  . GLN A 1 98  ? 182.64234 320.36007 -8.77126  1.000 79.05630  ? 94  GLN F CA  1 
ATOM   543  C C   . GLN A 1 98  ? 183.67715 321.47946 -8.78611  1.000 78.36356  ? 94  GLN F C   1 
ATOM   544  O O   . GLN A 1 98  ? 184.75684 321.33019 -8.19957  1.000 77.88828  ? 94  GLN F O   1 
ATOM   545  C CB  . GLN A 1 98  ? 182.70592 319.49648 -10.03226 1.000 79.14969  ? 94  GLN F CB  1 
ATOM   546  C CG  . GLN A 1 98  ? 182.02706 318.14396 -9.83212  1.000 80.10578  ? 94  GLN F CG  1 
ATOM   547  C CD  . GLN A 1 98  ? 182.01229 317.28086 -11.07824 1.000 80.04506  ? 94  GLN F CD  1 
ATOM   548  O OE1 . GLN A 1 98  ? 182.08656 317.78253 -12.20273 1.000 76.35918  ? 94  GLN F OE1 1 
ATOM   549  N NE2 . GLN A 1 98  ? 181.94070 315.96481 -10.88036 1.000 81.71163  ? 94  GLN F NE2 1 
ATOM   550  N N   . LEU A 1 99  ? 183.39010 322.58963 -9.47437  1.000 74.79132  ? 95  LEU F N   1 
ATOM   551  C CA  . LEU A 1 99  ? 184.34332 323.68574 -9.42603  1.000 78.95140  ? 95  LEU F CA  1 
ATOM   552  C C   . LEU A 1 99  ? 184.34735 324.35400 -8.06540  1.000 81.77667  ? 95  LEU F C   1 
ATOM   553  O O   . LEU A 1 99  ? 185.33824 324.99606 -7.70974  1.000 85.41234  ? 95  LEU F O   1 
ATOM   554  C CB  . LEU A 1 99  ? 183.99905 324.76445 -10.45479 1.000 71.70567  ? 95  LEU F CB  1 
ATOM   555  C CG  . LEU A 1 99  ? 183.47722 324.36195 -11.83004 1.000 76.18700  ? 95  LEU F CG  1 
ATOM   556  C CD1 . LEU A 1 99  ? 182.65280 325.47979 -12.41344 1.000 76.51108  ? 95  LEU F CD1 1 
ATOM   557  C CD2 . LEU A 1 99  ? 184.63568 324.01246 -12.75652 1.000 76.98948  ? 95  LEU F CD2 1 
ATOM   558  N N   . LEU A 1 100 ? 183.29856 324.16226 -7.26621  1.000 77.13381  ? 96  LEU F N   1 
ATOM   559  C CA  . LEU A 1 100 ? 183.34503 324.68631 -5.91268  1.000 78.45918  ? 96  LEU F CA  1 
ATOM   560  C C   . LEU A 1 100 ? 184.28022 323.86656 -5.04336  1.000 86.07398  ? 96  LEU F C   1 
ATOM   561  O O   . LEU A 1 100 ? 184.96123 324.42344 -4.17188  1.000 83.95980  ? 96  LEU F O   1 
ATOM   562  C CB  . LEU A 1 100 ? 181.93856 324.71148 -5.30953  1.000 73.52138  ? 96  LEU F CB  1 
ATOM   563  C CG  . LEU A 1 100 ? 181.83519 325.22605 -3.88794  1.000 69.89555  ? 96  LEU F CG  1 
ATOM   564  C CD1 . LEU A 1 100 ? 182.26543 326.68570 -3.86830  1.000 66.69242  ? 96  LEU F CD1 1 
ATOM   565  C CD2 . LEU A 1 100 ? 180.42228 325.06183 -3.38096  1.000 67.29285  ? 96  LEU F CD2 1 
ATOM   566  N N   . MET A 1 101 ? 184.37954 322.55838 -5.30142  1.000 84.55648  ? 97  MET F N   1 
ATOM   567  C CA  . MET A 1 101 ? 185.27713 321.75784 -4.46874  1.000 86.25426  ? 97  MET F CA  1 
ATOM   568  C C   . MET A 1 101 ? 186.70168 321.67802 -5.00660  1.000 91.95211  ? 97  MET F C   1 
ATOM   569  O O   . MET A 1 101 ? 187.63018 321.39362 -4.23985  1.000 89.26758  ? 97  MET F O   1 
ATOM   570  C CB  . MET A 1 101 ? 184.72519 320.33664 -4.29738  1.000 83.86588  ? 97  MET F CB  1 
ATOM   571  C CG  . MET A 1 101 ? 183.72585 320.25158 -3.16736  1.000 87.55326  ? 97  MET F CG  1 
ATOM   572  S SD  . MET A 1 101 ? 184.44297 320.80906 -1.58717  1.000 106.22460 ? 97  MET F SD  1 
ATOM   573  C CE  . MET A 1 101 ? 186.21608 320.56543 -1.83146  1.000 95.59976  ? 97  MET F CE  1 
ATOM   574  N N   . GLN A 1 102 ? 186.88055 321.94337 -6.29917  1.000 92.74746  ? 98  GLN F N   1 
ATOM   575  C CA  . GLN A 1 102 ? 188.20426 322.08247 -6.89635  1.000 96.79180  ? 98  GLN F CA  1 
ATOM   576  C C   . GLN A 1 102 ? 188.97582 323.26446 -6.31657  1.000 96.86463  ? 98  GLN F C   1 
ATOM   577  O O   . GLN A 1 102 ? 190.17189 323.15413 -6.00976  1.000 98.64805  ? 98  GLN F O   1 
ATOM   578  C CB  . GLN A 1 102 ? 188.04426 322.18074 -8.41741  1.000 92.06186  ? 98  GLN F CB  1 
ATOM   579  C CG  . GLN A 1 102 ? 189.32785 322.27727 -9.21799  1.000 99.71839  ? 98  GLN F CG  1 
ATOM   580  C CD  . GLN A 1 102 ? 189.04667 322.65430 -10.66642 1.000 105.27229 ? 98  GLN F CD  1 
ATOM   581  O OE1 . GLN A 1 102 ? 189.68039 323.55729 -11.22584 1.000 102.95265 ? 98  GLN F OE1 1 
ATOM   582  N NE2 . GLN A 1 102 ? 188.11498 321.94141 -11.28830 1.000 101.03425 ? 98  GLN F NE2 1 
ATOM   583  N N   . SER A 1 103 ? 188.30114 324.38892 -6.12142  1.000 93.78501  ? 99  SER F N   1 
ATOM   584  C CA  . SER A 1 103 ? 188.92668 325.57263 -5.54387  1.000 96.64832  ? 99  SER F CA  1 
ATOM   585  C C   . SER A 1 103 ? 187.96364 326.16630 -4.53594  1.000 96.17563  ? 99  SER F C   1 
ATOM   586  O O   . SER A 1 103 ? 186.96716 326.79402 -4.91866  1.000 93.01873  ? 99  SER F O   1 
ATOM   587  C CB  . SER A 1 103 ? 189.27790 326.60947 -6.62126  1.000 96.66367  ? 99  SER F CB  1 
ATOM   588  O OG  . SER A 1 103 ? 188.12350 327.14590 -7.26673  1.000 89.47921  ? 99  SER F OG  1 
ATOM   589  N N   . THR A 1 104 ? 188.29270 326.02639 -3.25236  1.000 98.32983  ? 100 THR F N   1 
ATOM   590  C CA  . THR A 1 104 ? 187.38998 326.53724 -2.24275  1.000 99.47552  ? 100 THR F CA  1 
ATOM   591  C C   . THR A 1 104 ? 187.99748 327.78533 -1.60859  1.000 95.52021  ? 100 THR F C   1 
ATOM   592  O O   . THR A 1 104 ? 189.08804 327.73113 -1.01078  1.000 95.68637  ? 100 THR F O   1 
ATOM   593  C CB  . THR A 1 104 ? 187.13455 325.45250 -1.17124  1.000 106.48204 ? 100 THR F CB  1 
ATOM   594  O OG1 . THR A 1 104 ? 188.37797 325.02103 -0.59236  1.000 111.43228 ? 100 THR F OG1 1 
ATOM   595  C CG2 . THR A 1 104 ? 186.44620 324.21466 -1.76988  1.000 95.29961  ? 100 THR F CG2 1 
ATOM   596  N N   . PRO A 1 105 ? 187.33852 328.93665 -1.78657  1.000 90.61897  ? 101 PRO F N   1 
ATOM   597  C CA  . PRO A 1 105 ? 187.82804 330.18587 -1.18728  1.000 87.65809  ? 101 PRO F CA  1 
ATOM   598  C C   . PRO A 1 105 ? 187.71473 330.14195 0.33111   1.000 88.61429  ? 101 PRO F C   1 
ATOM   599  O O   . PRO A 1 105 ? 186.78403 329.54861 0.88397   1.000 95.01807  ? 101 PRO F O   1 
ATOM   600  C CB  . PRO A 1 105 ? 186.93160 331.27506 -1.80926  1.000 80.24991  ? 101 PRO F CB  1 
ATOM   601  C CG  . PRO A 1 105 ? 186.33417 330.64950 -3.04115  1.000 79.96268  ? 101 PRO F CG  1 
ATOM   602  C CD  . PRO A 1 105 ? 186.19895 329.17595 -2.69728  1.000 92.46262  ? 101 PRO F CD  1 
ATOM   603  N N   . ALA A 1 106 ? 188.70523 330.71539 1.00813   1.000 90.43527  ? 102 ALA F N   1 
ATOM   604  C CA  . ALA A 1 106 ? 188.65636 330.76564 2.45981   1.000 82.42746  ? 102 ALA F CA  1 
ATOM   605  C C   . ALA A 1 106 ? 187.50789 331.67139 2.88734   1.000 85.72119  ? 102 ALA F C   1 
ATOM   606  O O   . ALA A 1 106 ? 187.12125 332.60389 2.17448   1.000 86.66346  ? 102 ALA F O   1 
ATOM   607  C CB  . ALA A 1 106 ? 189.97626 331.27486 3.03796   1.000 67.68723  ? 102 ALA F CB  1 
ATOM   608  N N   . THR A 1 107 ? 186.89978 331.33267 4.01783   1.000 83.05330  ? 103 THR F N   1 
ATOM   609  C CA  . THR A 1 107 ? 185.78154 332.09439 4.54345   1.000 84.39654  ? 103 THR F CA  1 
ATOM   610  C C   . THR A 1 107 ? 186.15024 332.63847 5.92114   1.000 83.50529  ? 103 THR F C   1 
ATOM   611  O O   . THR A 1 107 ? 187.09097 332.16049 6.57151   1.000 88.39467  ? 103 THR F O   1 
ATOM   612  C CB  . THR A 1 107 ? 184.49915 331.22751 4.62084   1.000 83.09895  ? 103 THR F CB  1 
ATOM   613  O OG1 . THR A 1 107 ? 183.45204 331.96183 5.27268   1.000 79.20006  ? 103 THR F OG1 1 
ATOM   614  C CG2 . THR A 1 107 ? 184.74636 329.88569 5.36796   1.000 69.45728  ? 103 THR F CG2 1 
ATOM   615  N N   . GLY A 1 108 ? 185.42514 333.68537 6.34230   1.000 84.25482  ? 143 GLY F N   1 
ATOM   616  C CA  . GLY A 1 108 ? 185.59607 334.24078 7.68115   1.000 85.61681  ? 143 GLY F CA  1 
ATOM   617  C C   . GLY A 1 108 ? 185.07194 333.35198 8.79511   1.000 79.96141  ? 143 GLY F C   1 
ATOM   618  O O   . GLY A 1 108 ? 185.19292 333.70247 9.97704   1.000 80.64981  ? 143 GLY F O   1 
ATOM   619  N N   . SER A 1 109 ? 184.48285 332.20971 8.42462   1.000 76.01550  ? 144 SER F N   1 
ATOM   620  C CA  . SER A 1 109 ? 183.94678 331.20857 9.33723   1.000 71.62046  ? 144 SER F CA  1 
ATOM   621  C C   . SER A 1 109 ? 184.91978 330.05410 9.58060   1.000 66.44206  ? 144 SER F C   1 
ATOM   622  O O   . SER A 1 109 ? 184.56119 329.09522 10.27604  1.000 53.73287  ? 144 SER F O   1 
ATOM   623  C CB  . SER A 1 109 ? 182.60793 330.67048 8.81259   1.000 73.19022  ? 144 SER F CB  1 
ATOM   624  O OG  . SER A 1 109 ? 181.67469 331.71107 8.53715   1.000 75.65164  ? 144 SER F OG  1 
ATOM   625  N N   . GLY A 1 110 ? 186.15665 330.13827 9.06250   1.000 63.77910  ? 145 GLY F N   1 
ATOM   626  C CA  . GLY A 1 110 ? 187.07545 329.02431 9.22434   1.000 56.39505  ? 145 GLY F CA  1 
ATOM   627  C C   . GLY A 1 110 ? 187.40436 328.70400 10.67596  1.000 56.56509  ? 145 GLY F C   1 
ATOM   628  O O   . GLY A 1 110 ? 187.56868 327.52691 11.02603  1.000 56.83279  ? 145 GLY F O   1 
ATOM   629  N N   . SER A 1 111 ? 187.37582 329.71457 11.56007  1.000 52.14714  ? 146 SER F N   1 
ATOM   630  C CA  . SER A 1 111 ? 187.64002 329.52314 12.98578  1.000 55.21088  ? 146 SER F CA  1 
ATOM   631  C C   . SER A 1 111 ? 186.48085 328.83958 13.71769  1.000 54.43829  ? 146 SER F C   1 
ATOM   632  O O   . SER A 1 111 ? 186.61542 328.52483 14.90499  1.000 47.11571  ? 146 SER F O   1 
ATOM   633  C CB  . SER A 1 111 ? 187.96197 330.85630 13.67345  1.000 50.63530  ? 146 SER F CB  1 
ATOM   634  O OG  . SER A 1 111 ? 186.89330 331.76806 13.50610  1.000 63.86954  ? 146 SER F OG  1 
ATOM   635  N N   . ALA A 1 112 ? 185.37199 328.55694 13.04117  1.000 48.55687  ? 147 ALA F N   1 
ATOM   636  C CA  . ALA A 1 112 ? 184.24079 327.93127 13.68729  1.000 49.74342  ? 147 ALA F CA  1 
ATOM   637  C C   . ALA A 1 112 ? 183.81283 326.62362 13.04001  1.000 48.38923  ? 147 ALA F C   1 
ATOM   638  O O   . ALA A 1 112 ? 182.93223 325.94911 13.58951  1.000 48.52769  ? 147 ALA F O   1 
ATOM   639  C CB  . ALA A 1 112 ? 183.03526 328.88575 13.66078  1.000 45.52437  ? 147 ALA F CB  1 
ATOM   640  N N   . ILE A 1 113 ? 184.46011 326.19484 11.96339  1.000 43.44996  ? 148 ILE F N   1 
ATOM   641  C CA  . ILE A 1 113 ? 184.01393 325.00242 11.25645  1.000 54.39621  ? 148 ILE F CA  1 
ATOM   642  C C   . ILE A 1 113 ? 185.03037 323.86139 11.22193  1.000 57.09501  ? 148 ILE F C   1 
ATOM   643  O O   . ILE A 1 113 ? 184.86088 322.93708 10.42994  1.000 56.44151  ? 148 ILE F O   1 
ATOM   644  C CB  . ILE A 1 113 ? 183.60711 325.38794 9.82428   1.000 51.60418  ? 148 ILE F CB  1 
ATOM   645  C CG1 . ILE A 1 113 ? 184.82168 325.96441 9.10351   1.000 48.26489  ? 148 ILE F CG1 1 
ATOM   646  C CG2 . ILE A 1 113 ? 182.49485 326.41109 9.88350   1.000 45.13820  ? 148 ILE F CG2 1 
ATOM   647  C CD1 . ILE A 1 113 ? 184.54217 326.36623 7.64846   1.000 56.08603  ? 148 ILE F CD1 1 
ATOM   648  N N   . CYS A 1 114 ? 186.07096 323.86997 12.05087  1.000 48.82577  ? 149 CYS F N   1 
ATOM   649  C CA  . CYS A 1 114 ? 187.01584 322.76124 11.95739  1.000 56.33071  ? 149 CYS F CA  1 
ATOM   650  C C   . CYS A 1 114 ? 186.36987 321.39766 12.24286  1.000 53.33735  ? 149 CYS F C   1 
ATOM   651  O O   . CYS A 1 114 ? 186.75872 320.40511 11.62187  1.000 50.20257  ? 149 CYS F O   1 
ATOM   652  C CB  . CYS A 1 114 ? 188.24885 323.03974 12.83990  1.000 62.36686  ? 149 CYS F CB  1 
ATOM   653  S SG  . CYS A 1 114 ? 188.00125 323.06600 14.64719  1.000 70.54211  ? 149 CYS F SG  1 
ATOM   654  N N   . SER A 1 115 ? 185.34533 321.31638 13.09733  1.000 51.51361  ? 150 SER F N   1 
ATOM   655  C CA  . SER A 1 115 ? 184.79033 319.99343 13.37961  1.000 52.20514  ? 150 SER F CA  1 
ATOM   656  C C   . SER A 1 115 ? 184.11321 319.41448 12.15066  1.000 61.30006  ? 150 SER F C   1 
ATOM   657  O O   . SER A 1 115 ? 184.40660 318.28058 11.74960  1.000 62.28377  ? 150 SER F O   1 
ATOM   658  C CB  . SER A 1 115 ? 183.80893 320.02482 14.55163  1.000 55.31190  ? 150 SER F CB  1 
ATOM   659  O OG  . SER A 1 115 ? 183.07567 321.22049 14.57277  1.000 65.68715  ? 150 SER F OG  1 
ATOM   660  N N   . GLY A 1 116 ? 183.20453 320.17377 11.52736  1.000 60.63174  ? 151 GLY F N   1 
ATOM   661  C CA  . GLY A 1 116 ? 182.57042 319.66112 10.32428  1.000 53.46946  ? 151 GLY F CA  1 
ATOM   662  C C   . GLY A 1 116 ? 183.56487 319.47282 9.19401   1.000 57.89384  ? 151 GLY F C   1 
ATOM   663  O O   . GLY A 1 116 ? 183.44316 318.54243 8.39262   1.000 66.64687  ? 151 GLY F O   1 
ATOM   664  N N   . VAL A 1 117 ? 184.55896 320.35570 9.09984   1.000 57.91894  ? 152 VAL F N   1 
ATOM   665  C CA  . VAL A 1 117 ? 185.56987 320.18369 8.05365   1.000 61.85354  ? 152 VAL F CA  1 
ATOM   666  C C   . VAL A 1 117 ? 186.35926 318.89456 8.26568   1.000 66.36036  ? 152 VAL F C   1 
ATOM   667  O O   . VAL A 1 117 ? 186.76838 318.24091 7.29467   1.000 68.09672  ? 152 VAL F O   1 
ATOM   668  C CB  . VAL A 1 117 ? 186.50337 321.40018 7.95813   1.000 50.70562  ? 152 VAL F CB  1 
ATOM   669  C CG1 . VAL A 1 117 ? 187.73345 321.04447 7.12772   1.000 53.79016  ? 152 VAL F CG1 1 
ATOM   670  C CG2 . VAL A 1 117 ? 185.77236 322.56665 7.35495   1.000 53.56500  ? 152 VAL F CG2 1 
ATOM   671  N N   . ALA A 1 118 ? 186.58853 318.50168 9.53058   1.000 62.00027  ? 153 ALA F N   1 
ATOM   672  C CA  . ALA A 1 118 ? 187.31063 317.25317 9.76779   1.000 65.50382  ? 153 ALA F CA  1 
ATOM   673  C C   . ALA A 1 118 ? 186.54538 316.07328 9.20711   1.000 66.92977  ? 153 ALA F C   1 
ATOM   674  O O   . ALA A 1 118 ? 187.14549 315.08328 8.78591   1.000 72.08681  ? 153 ALA F O   1 
ATOM   675  C CB  . ALA A 1 118 ? 187.56454 317.03901 11.26175  1.000 51.42647  ? 153 ALA F CB  1 
ATOM   676  N N   . VAL A 1 119 ? 185.22867 316.16723 9.15180   1.000 68.17319  ? 154 VAL F N   1 
ATOM   677  C CA  . VAL A 1 119 ? 184.48610 315.05096 8.59425   1.000 68.59556  ? 154 VAL F CA  1 
ATOM   678  C C   . VAL A 1 119 ? 184.62513 315.04833 7.07359   1.000 72.36153  ? 154 VAL F C   1 
ATOM   679  O O   . VAL A 1 119 ? 184.76588 313.99043 6.45446   1.000 77.03548  ? 154 VAL F O   1 
ATOM   680  C CB  . VAL A 1 119 ? 183.02257 315.12997 9.05292   1.000 64.69235  ? 154 VAL F CB  1 
ATOM   681  C CG1 . VAL A 1 119 ? 182.23078 313.92785 8.55017   1.000 76.89696  ? 154 VAL F CG1 1 
ATOM   682  C CG2 . VAL A 1 119 ? 182.96076 315.25782 10.59172  1.000 57.11830  ? 154 VAL F CG2 1 
ATOM   683  N N   . CYS A 1 120 ? 184.64410 316.23575 6.45740   1.000 72.21821  ? 155 CYS F N   1 
ATOM   684  C CA  . CYS A 1 120 ? 184.80774 316.33028 5.00915   1.000 70.33776  ? 155 CYS F CA  1 
ATOM   685  C C   . CYS A 1 120 ? 186.17574 315.85058 4.55965   1.000 73.50929  ? 155 CYS F C   1 
ATOM   686  O O   . CYS A 1 120 ? 186.30204 315.28832 3.46795   1.000 78.96561  ? 155 CYS F O   1 
ATOM   687  C CB  . CYS A 1 120 ? 184.62321 317.77633 4.54211   1.000 66.67883  ? 155 CYS F CB  1 
ATOM   688  S SG  . CYS A 1 120 ? 182.89616 318.44812 4.51507   1.000 82.23738  ? 155 CYS F SG  1 
ATOM   689  N N   . LYS A 1 121 ? 187.21201 316.06341 5.37088   1.000 74.43366  ? 156 LYS F N   1 
ATOM   690  C CA  . LYS A 1 121 ? 188.52783 315.59833 4.95662   1.000 75.93459  ? 156 LYS F CA  1 
ATOM   691  C C   . LYS A 1 121 ? 188.60305 314.07670 4.96441   1.000 75.24816  ? 156 LYS F C   1 
ATOM   692  O O   . LYS A 1 121 ? 189.22124 313.48415 4.07757   1.000 77.99590  ? 156 LYS F O   1 
ATOM   693  C CB  . LYS A 1 121 ? 189.57094 316.20346 5.90375   1.000 71.16715  ? 156 LYS F CB  1 
ATOM   694  C CG  . LYS A 1 121 ? 190.13230 317.57753 5.45249   1.000 75.53524  ? 156 LYS F CG  1 
ATOM   695  C CD  . LYS A 1 121 ? 191.12124 318.22845 6.46359   1.000 84.34215  ? 156 LYS F CD  1 
ATOM   696  C CE  . LYS A 1 121 ? 190.49579 318.51846 7.84737   1.000 78.64597  ? 156 LYS F CE  1 
ATOM   697  N NZ  . LYS A 1 121 ? 191.20286 319.59486 8.63178   1.000 73.30967  ? 156 LYS F NZ  1 
ATOM   698  N N   . VAL A 1 122 ? 187.85023 313.43754 5.85647   1.000 75.74185  ? 157 VAL F N   1 
ATOM   699  C CA  . VAL A 1 122 ? 187.79172 311.98010 5.93690   1.000 81.77311  ? 157 VAL F CA  1 
ATOM   700  C C   . VAL A 1 122 ? 187.02983 311.40393 4.75140   1.000 87.40450  ? 157 VAL F C   1 
ATOM   701  O O   . VAL A 1 122 ? 187.37891 310.34779 4.20942   1.000 91.33520  ? 157 VAL F O   1 
ATOM   702  C CB  . VAL A 1 122 ? 187.18601 311.54195 7.27633   1.000 85.45277  ? 157 VAL F CB  1 
ATOM   703  C CG1 . VAL A 1 122 ? 187.06193 310.01373 7.34007   1.000 97.55861  ? 157 VAL F CG1 1 
ATOM   704  C CG2 . VAL A 1 122 ? 188.02650 312.09542 8.41555   1.000 86.98573  ? 157 VAL F CG2 1 
ATOM   705  N N   . LEU A 1 123 ? 185.97784 312.09796 4.32999   1.000 86.97455  ? 158 LEU F N   1 
ATOM   706  C CA  . LEU A 1 123 ? 185.14702 311.63480 3.23038   1.000 85.85326  ? 158 LEU F CA  1 
ATOM   707  C C   . LEU A 1 123 ? 185.95383 311.60154 1.93889   1.000 84.29561  ? 158 LEU F C   1 
ATOM   708  O O   . LEU A 1 123 ? 185.67215 310.79680 1.04581   1.000 92.21630  ? 158 LEU F O   1 
ATOM   709  C CB  . LEU A 1 123 ? 183.92837 312.55890 3.13037   1.000 85.18421  ? 158 LEU F CB  1 
ATOM   710  C CG  . LEU A 1 123 ? 182.77359 312.03063 3.99897   1.000 81.99262  ? 158 LEU F CG  1 
ATOM   711  C CD1 . LEU A 1 123 ? 181.51581 312.88566 3.86925   1.000 77.04468  ? 158 LEU F CD1 1 
ATOM   712  C CD2 . LEU A 1 123 ? 182.48883 310.54342 3.75864   1.000 90.56607  ? 158 LEU F CD2 1 
ATOM   713  N N   . HIS A 1 124 ? 186.96305 312.45772 1.82687   1.000 82.45342  ? 159 HIS F N   1 
ATOM   714  C CA  . HIS A 1 124 ? 187.81755 312.47947 0.65372   1.000 86.23775  ? 159 HIS F CA  1 
ATOM   715  C C   . HIS A 1 124 ? 188.71268 311.24992 0.55542   1.000 92.82173  ? 159 HIS F C   1 
ATOM   716  O O   . HIS A 1 124 ? 189.31592 311.02406 -0.50122  1.000 93.74151  ? 159 HIS F O   1 
ATOM   717  C CB  . HIS A 1 124 ? 188.69911 313.71714 0.67843   1.000 79.87369  ? 159 HIS F CB  1 
ATOM   718  C CG  . HIS A 1 124 ? 188.09592 314.89224 -0.00517  1.000 81.52600  ? 159 HIS F CG  1 
ATOM   719  N ND1 . HIS A 1 124 ? 187.11471 315.66315 0.57974   1.000 81.05264  ? 159 HIS F ND1 1 
ATOM   720  C CD2 . HIS A 1 124 ? 188.32802 315.42979 -1.22526  1.000 79.40613  ? 159 HIS F CD2 1 
ATOM   721  C CE1 . HIS A 1 124 ? 186.77245 316.63212 -0.25073  1.000 83.56012  ? 159 HIS F CE1 1 
ATOM   722  N NE2 . HIS A 1 124 ? 187.49432 316.51346 -1.35206  1.000 86.07434  ? 159 HIS F NE2 1 
ATOM   723  N N   . LEU A 1 125 ? 188.80954 310.44811 1.61133   1.000 94.19302  ? 160 LEU F N   1 
ATOM   724  C CA  . LEU A 1 125 ? 189.59480 309.22822 1.52476   1.000 95.01691  ? 160 LEU F CA  1 
ATOM   725  C C   . LEU A 1 125 ? 188.94754 308.23016 0.57094   1.000 102.01866 ? 160 LEU F C   1 
ATOM   726  O O   . LEU A 1 125 ? 187.72174 308.18059 0.41042   1.000 103.60097 ? 160 LEU F O   1 
ATOM   727  C CB  . LEU A 1 125 ? 189.74570 308.59720 2.90846   1.000 92.42079  ? 160 LEU F CB  1 
ATOM   728  C CG  . LEU A 1 125 ? 190.40946 309.50824 3.94335   1.000 89.39077  ? 160 LEU F CG  1 
ATOM   729  C CD1 . LEU A 1 125 ? 190.55076 308.80453 5.28769   1.000 84.29819  ? 160 LEU F CD1 1 
ATOM   730  C CD2 . LEU A 1 125 ? 191.74887 310.03291 3.43300   1.000 83.04921  ? 160 LEU F CD2 1 
ATOM   731  N N   . GLU A 1 126 ? 189.79924 307.41297 -0.04938  1.000 105.98137 ? 161 GLU F N   1 
ATOM   732  C CA  . GLU A 1 126 ? 189.34170 306.42233 -1.01492  1.000 107.31953 ? 161 GLU F CA  1 
ATOM   733  C C   . GLU A 1 126 ? 188.62697 305.28892 -0.30469  1.000 105.17013 ? 161 GLU F C   1 
ATOM   734  O O   . GLU A 1 126 ? 189.14669 304.71630 0.66029   1.000 99.77781  ? 161 GLU F O   1 
ATOM   735  C CB  . GLU A 1 126 ? 190.52334 305.87874 -1.80807  1.000 110.14519 ? 161 GLU F CB  1 
ATOM   736  C CG  . GLU A 1 126 ? 191.07590 306.84840 -2.83427  1.000 112.79813 ? 161 GLU F CG  1 
ATOM   737  C CD  . GLU A 1 126 ? 192.59267 306.93035 -2.78057  1.000 118.50823 ? 161 GLU F CD  1 
ATOM   738  O OE1 . GLU A 1 126 ? 193.26537 306.06019 -3.38268  1.000 115.39273 ? 161 GLU F OE1 1 
ATOM   739  O OE2 . GLU A 1 126 ? 193.10995 307.86804 -2.12853  1.000 113.00170 ? 161 GLU F OE2 1 
ATOM   740  N N   . GLY A 1 127 ? 187.40936 305.00397 -0.74565  1.000 107.12277 ? 162 GLY F N   1 
ATOM   741  C CA  . GLY A 1 127 ? 186.63992 303.94500 -0.14826  1.000 106.50920 ? 162 GLY F CA  1 
ATOM   742  C C   . GLY A 1 127 ? 185.69998 304.44650 0.91412   1.000 107.66552 ? 162 GLY F C   1 
ATOM   743  O O   . GLY A 1 127 ? 184.78904 303.71455 1.32631   1.000 106.16203 ? 162 GLY F O   1 
ATOM   744  N N   . GLU A 1 128 ? 185.87837 305.69537 1.34064   1.000 108.38851 ? 163 GLU F N   1 
ATOM   745  C CA  . GLU A 1 128 ? 185.05843 306.22129 2.41614   1.000 104.37724 ? 163 GLU F CA  1 
ATOM   746  C C   . GLU A 1 128 ? 183.69914 306.66222 1.88957   1.000 103.22480 ? 163 GLU F C   1 
ATOM   747  O O   . GLU A 1 128 ? 182.66936 306.39676 2.52386   1.000 100.74529 ? 163 GLU F O   1 
ATOM   748  C CB  . GLU A 1 128 ? 185.79822 307.38393 3.07616   1.000 101.74795 ? 163 GLU F CB  1 
ATOM   749  C CG  . GLU A 1 128 ? 185.45718 307.61390 4.53749   1.000 106.21354 ? 163 GLU F CG  1 
ATOM   750  C CD  . GLU A 1 128 ? 185.85034 306.44103 5.42832   1.000 112.75430 ? 163 GLU F CD  1 
ATOM   751  O OE1 . GLU A 1 128 ? 185.47155 306.45160 6.61943   1.000 112.61089 ? 163 GLU F OE1 1 
ATOM   752  O OE2 . GLU A 1 128 ? 186.55840 305.52402 4.94939   1.000 111.32819 ? 163 GLU F OE2 1 
ATOM   753  N N   . VAL A 1 129 ? 183.66360 307.28021 0.70623   1.000 100.58225 ? 164 VAL F N   1 
ATOM   754  C CA  . VAL A 1 129 ? 182.36511 307.59399 0.12390   1.000 102.53034 ? 164 VAL F CA  1 
ATOM   755  C C   . VAL A 1 129 ? 181.61133 306.32700 -0.23435  1.000 104.50307 ? 164 VAL F C   1 
ATOM   756  O O   . VAL A 1 129 ? 180.37385 306.29372 -0.18932  1.000 100.28525 ? 164 VAL F O   1 
ATOM   757  C CB  . VAL A 1 129 ? 182.58136 308.47386 -1.11832  1.000 101.11652 ? 164 VAL F CB  1 
ATOM   758  C CG1 . VAL A 1 129 ? 181.26036 308.91914 -1.70308  1.000 93.85318  ? 164 VAL F CG1 1 
ATOM   759  C CG2 . VAL A 1 129 ? 183.42741 309.67738 -0.73408  1.000 103.24335 ? 164 VAL F CG2 1 
ATOM   760  N N   . ASN A 1 130 ? 182.34407 305.25866 -0.55041  1.000 103.54499 ? 165 ASN F N   1 
ATOM   761  C CA  . ASN A 1 130 ? 181.74810 303.95871 -0.83251  1.000 103.81362 ? 165 ASN F CA  1 
ATOM   762  C C   . ASN A 1 130 ? 181.13361 303.32960 0.41278   1.000 102.13786 ? 165 ASN F C   1 
ATOM   763  O O   . ASN A 1 130 ? 180.18972 302.54116 0.30258   1.000 99.80977  ? 165 ASN F O   1 
ATOM   764  C CB  . ASN A 1 130 ? 182.78540 303.06149 -1.49772  1.000 106.07374 ? 165 ASN F CB  1 
ATOM   765  C CG  . ASN A 1 130 ? 183.38603 303.71642 -2.73029  1.000 110.07250 ? 165 ASN F CG  1 
ATOM   766  O OD1 . ASN A 1 130 ? 184.21692 304.62903 -2.62539  1.000 111.08673 ? 165 ASN F OD1 1 
ATOM   767  N ND2 . ASN A 1 130 ? 182.92989 303.29250 -3.90484  1.000 106.31726 ? 165 ASN F ND2 1 
ATOM   768  N N   . LYS A 1 131 ? 181.61840 303.69850 1.59966   1.000 97.84721  ? 166 LYS F N   1 
ATOM   769  C CA  . LYS A 1 131 ? 181.10209 303.10646 2.82435   1.000 99.06837  ? 166 LYS F CA  1 
ATOM   770  C C   . LYS A 1 131 ? 179.70712 303.63406 3.10294   1.000 101.89112 ? 166 LYS F C   1 
ATOM   771  O O   . LYS A 1 131 ? 178.76208 302.86237 3.31265   1.000 99.03277  ? 166 LYS F O   1 
ATOM   772  C CB  . LYS A 1 131 ? 182.03125 303.49344 3.98121   1.000 101.48996 ? 166 LYS F CB  1 
ATOM   773  C CG  . LYS A 1 131 ? 181.65442 302.95007 5.35812   1.000 103.29299 ? 166 LYS F CG  1 
ATOM   774  C CD  . LYS A 1 131 ? 182.60946 303.50359 6.43447   1.000 107.67260 ? 166 LYS F CD  1 
ATOM   775  C CE  . LYS A 1 131 ? 184.06945 303.15361 6.19326   1.000 109.19826 ? 166 LYS F CE  1 
ATOM   776  N NZ  . LYS A 1 131 ? 184.98318 303.71769 7.24520   1.000 113.12051 ? 166 LYS F NZ  1 
ATOM   777  N N   . ILE A 1 132 ? 179.56889 304.95827 3.13424   1.000 102.76659 ? 167 ILE F N   1 
ATOM   778  C CA  . ILE A 1 132 ? 178.26109 305.56930 3.32812   1.000 103.46446 ? 167 ILE F CA  1 
ATOM   779  C C   . ILE A 1 132 ? 177.34555 305.24316 2.15923   1.000 100.51869 ? 167 ILE F C   1 
ATOM   780  O O   . ILE A 1 132 ? 176.12813 305.09923 2.33280   1.000 97.16973  ? 167 ILE F O   1 
ATOM   781  C CB  . ILE A 1 132 ? 178.43940 307.08632 3.54747   1.000 103.23580 ? 167 ILE F CB  1 
ATOM   782  C CG1 . ILE A 1 132 ? 179.32061 307.67003 2.43935   1.000 100.69328 ? 167 ILE F CG1 1 
ATOM   783  C CG2 . ILE A 1 132 ? 178.97056 307.39467 4.94149   1.000 105.48119 ? 167 ILE F CG2 1 
ATOM   784  C CD1 . ILE A 1 132 ? 179.69703 309.10398 2.67381   1.000 99.35038  ? 167 ILE F CD1 1 
ATOM   785  N N   . LYS A 1 133 ? 177.92040 305.06194 0.96250   1.000 102.52030 ? 168 LYS F N   1 
ATOM   786  C CA  . LYS A 1 133 ? 177.12051 304.70679 -0.20648  1.000 99.17914  ? 168 LYS F CA  1 
ATOM   787  C C   . LYS A 1 133 ? 176.50545 303.32681 -0.05546  1.000 99.32697  ? 168 LYS F C   1 
ATOM   788  O O   . LYS A 1 133 ? 175.41376 303.07882 -0.57124  1.000 103.74942 ? 168 LYS F O   1 
ATOM   789  C CB  . LYS A 1 133 ? 178.03299 304.77389 -1.43501  1.000 101.57274 ? 168 LYS F CB  1 
ATOM   790  C CG  . LYS A 1 133 ? 177.42164 304.79192 -2.83241  1.000 95.13679  ? 168 LYS F CG  1 
ATOM   791  C CD  . LYS A 1 133 ? 178.57800 304.97101 -3.82854  1.000 93.29967  ? 168 LYS F CD  1 
ATOM   792  C CE  . LYS A 1 133 ? 178.11208 305.09673 -5.24163  1.000 89.58001  ? 168 LYS F CE  1 
ATOM   793  N NZ  . LYS A 1 133 ? 176.96011 306.01639 -5.24232  1.000 97.26006  ? 168 LYS F NZ  1 
ATOM   794  N N   . SER A 1 134 ? 177.15755 302.44246 0.69728   1.000 99.17393  ? 169 SER F N   1 
ATOM   795  C CA  . SER A 1 134 ? 176.65617 301.10148 0.97668   1.000 97.93462  ? 169 SER F CA  1 
ATOM   796  C C   . SER A 1 134 ? 175.70975 301.06534 2.16777   1.000 101.98157 ? 169 SER F C   1 
ATOM   797  O O   . SER A 1 134 ? 174.68899 300.36360 2.12873   1.000 99.34415  ? 169 SER F O   1 
ATOM   798  C CB  . SER A 1 134 ? 177.81407 300.13480 1.20876   1.000 98.97494  ? 169 SER F CB  1 
ATOM   799  O OG  . SER A 1 134 ? 178.63852 300.07828 0.06374   1.000 102.55092 ? 169 SER F OG  1 
ATOM   800  N N   . ALA A 1 135 ? 176.00691 301.84716 3.21188   1.000 100.95789 ? 170 ALA F N   1 
ATOM   801  C CA  . ALA A 1 135 ? 175.15350 301.81846 4.39192   1.000 97.01278  ? 170 ALA F CA  1 
ATOM   802  C C   . ALA A 1 135 ? 173.78521 302.40802 4.08958   1.000 99.17073  ? 170 ALA F C   1 
ATOM   803  O O   . ALA A 1 135 ? 172.77498 301.97404 4.65498   1.000 98.63171  ? 170 ALA F O   1 
ATOM   804  C CB  . ALA A 1 135 ? 175.83537 302.56268 5.53620   1.000 96.09665  ? 170 ALA F CB  1 
ATOM   805  N N   . LEU A 1 136 ? 173.73560 303.43689 3.24509   1.000 102.31809 ? 171 LEU F N   1 
ATOM   806  C CA  . LEU A 1 136 ? 172.46539 304.02534 2.84167   1.000 103.34622 ? 171 LEU F CA  1 
ATOM   807  C C   . LEU A 1 136 ? 171.92728 303.41739 1.54774   1.000 101.47110 ? 171 LEU F C   1 
ATOM   808  O O   . LEU A 1 136 ? 171.23590 304.10733 0.78264   1.000 98.17494  ? 171 LEU F O   1 
ATOM   809  C CB  . LEU A 1 136 ? 172.62243 305.53794 2.71010   1.000 98.86615  ? 171 LEU F CB  1 
ATOM   810  C CG  . LEU A 1 136 ? 172.94682 306.24937 4.01896   1.000 94.53186  ? 171 LEU F CG  1 
ATOM   811  C CD1 . LEU A 1 136 ? 173.07947 307.74236 3.76675   1.000 88.98171  ? 171 LEU F CD1 1 
ATOM   812  C CD2 . LEU A 1 136 ? 171.86124 305.96103 5.06552   1.000 90.03036  ? 171 LEU F CD2 1 
ATOM   813  N N   . LEU A 1 137 ? 172.15945 302.12192 1.32133   1.000 104.67712 ? 172 LEU F N   1 
ATOM   814  C CA  . LEU A 1 137 ? 171.69334 301.47610 0.09575   1.000 105.47973 ? 172 LEU F CA  1 
ATOM   815  C C   . LEU A 1 137 ? 170.22019 301.11401 0.19387   1.000 101.57491 ? 172 LEU F C   1 
ATOM   816  O O   . LEU A 1 137 ? 169.50836 301.11121 -0.81721  1.000 97.12909  ? 172 LEU F O   1 
ATOM   817  C CB  . LEU A 1 137 ? 172.53928 300.23915 -0.21769  1.000 104.55221 ? 172 LEU F CB  1 
ATOM   818  C CG  . LEU A 1 137 ? 172.17501 299.50192 -1.50856  1.000 104.91261 ? 172 LEU F CG  1 
ATOM   819  C CD1 . LEU A 1 137 ? 172.41928 300.42692 -2.69973  1.000 99.83413  ? 172 LEU F CD1 1 
ATOM   820  C CD2 . LEU A 1 137 ? 172.97507 298.20297 -1.65386  1.000 94.18381  ? 172 LEU F CD2 1 
ATOM   821  N N   . SER A 1 138 ? 169.75554 300.81043 1.39976   1.000 101.96582 ? 173 SER F N   1 
ATOM   822  C CA  . SER A 1 138 ? 168.39680 300.36704 1.62895   1.000 96.35518  ? 173 SER F CA  1 
ATOM   823  C C   . SER A 1 138 ? 167.62316 301.31521 2.53074   1.000 97.09236  ? 173 SER F C   1 
ATOM   824  O O   . SER A 1 138 ? 166.38952 301.32574 2.45698   1.000 97.66186  ? 173 SER F O   1 
ATOM   825  C CB  . SER A 1 138 ? 168.37964 298.94631 2.21841   1.000 100.25339 ? 173 SER F CB  1 
ATOM   826  O OG  . SER A 1 138 ? 168.51923 298.96207 3.62901   1.000 106.08906 ? 173 SER F OG  1 
ATOM   827  N N   . THR A 1 139 ? 168.29746 302.10840 3.37323   1.000 102.72644 ? 174 THR F N   1 
ATOM   828  C CA  . THR A 1 139 ? 167.61236 302.98073 4.32304   1.000 104.91028 ? 174 THR F CA  1 
ATOM   829  C C   . THR A 1 139 ? 168.05268 304.43594 4.12834   1.000 99.03969  ? 174 THR F C   1 
ATOM   830  O O   . THR A 1 139 ? 169.03303 304.72727 3.43099   1.000 94.65503  ? 174 THR F O   1 
ATOM   831  C CB  . THR A 1 139 ? 167.90193 302.52404 5.76709   1.000 100.11756 ? 174 THR F CB  1 
ATOM   832  O OG1 . THR A 1 139 ? 167.11565 303.28108 6.70018   1.000 94.08122  ? 174 THR F OG1 1 
ATOM   833  C CG2 . THR A 1 139 ? 169.39793 302.67650 6.09255   1.000 92.83904  ? 174 THR F CG2 1 
ATOM   834  N N   . ASN A 1 140 ? 167.28300 305.36008 4.73751   1.000 100.04066 ? 175 ASN F N   1 
ATOM   835  C CA  . ASN A 1 140 ? 167.60687 306.79252 4.71728   1.000 101.80463 ? 175 ASN F CA  1 
ATOM   836  C C   . ASN A 1 140 ? 168.63185 307.22939 5.76823   1.000 99.52256  ? 175 ASN F C   1 
ATOM   837  O O   . ASN A 1 140 ? 169.50259 308.05575 5.46591   1.000 93.82151  ? 175 ASN F O   1 
ATOM   838  C CB  . ASN A 1 140 ? 166.33996 307.63503 4.84939   1.000 98.08223  ? 175 ASN F CB  1 
ATOM   839  C CG  . ASN A 1 140 ? 165.36951 307.39312 3.72173   1.000 104.33361 ? 175 ASN F CG  1 
ATOM   840  O OD1 . ASN A 1 140 ? 165.77990 307.06190 2.59846   1.000 94.65968  ? 175 ASN F OD1 1 
ATOM   841  N ND2 . ASN A 1 140 ? 164.07774 307.59181 3.99336   1.000 103.76290 ? 175 ASN F ND2 1 
ATOM   842  N N   . LYS A 1 141 ? 168.56157 306.69206 6.99323   1.000 100.97415 ? 176 LYS F N   1 
ATOM   843  C CA  . LYS A 1 141 ? 169.47013 307.07705 8.06975   1.000 98.28357  ? 176 LYS F CA  1 
ATOM   844  C C   . LYS A 1 141 ? 170.37670 305.91380 8.45219   1.000 97.69939  ? 176 LYS F C   1 
ATOM   845  O O   . LYS A 1 141 ? 169.97236 304.74887 8.40812   1.000 99.43115  ? 176 LYS F O   1 
ATOM   846  C CB  . LYS A 1 141 ? 168.70489 307.51339 9.33422   1.000 92.86521  ? 176 LYS F CB  1 
ATOM   847  C CG  . LYS A 1 141 ? 167.97166 308.84846 9.29072   1.000 90.51314  ? 176 LYS F CG  1 
ATOM   848  C CD  . LYS A 1 141 ? 166.45255 308.65016 9.28106   1.000 94.03495  ? 176 LYS F CD  1 
ATOM   849  C CE  . LYS A 1 141 ? 165.68805 309.98005 9.23258   1.000 91.27283  ? 176 LYS F CE  1 
ATOM   850  N NZ  . LYS A 1 141 ? 165.33302 310.40944 7.84208   1.000 84.81604  ? 176 LYS F NZ  1 
ATOM   851  N N   . ALA A 1 142 ? 171.60196 306.23811 8.85810   1.000 94.57139  ? 177 ALA F N   1 
ATOM   852  C CA  . ALA A 1 142 ? 172.52143 305.18493 9.25512   1.000 91.98350  ? 177 ALA F CA  1 
ATOM   853  C C   . ALA A 1 142 ? 173.74605 305.79590 9.92087   1.000 97.15380  ? 177 ALA F C   1 
ATOM   854  O O   . ALA A 1 142 ? 174.25952 306.82108 9.46316   1.000 95.09325  ? 177 ALA F O   1 
ATOM   855  C CB  . ALA A 1 142 ? 172.94063 304.34419 8.04111   1.000 96.27172  ? 177 ALA F CB  1 
ATOM   856  N N   . VAL A 1 143 ? 174.23628 305.12665 10.96641  1.000 97.41420  ? 178 VAL F N   1 
ATOM   857  C CA  . VAL A 1 143 ? 175.46295 305.51137 11.65199  1.000 95.26306  ? 178 VAL F CA  1 
ATOM   858  C C   . VAL A 1 143 ? 176.62578 304.87837 10.90506  1.000 94.80130  ? 178 VAL F C   1 
ATOM   859  O O   . VAL A 1 143 ? 176.54858 303.72283 10.48085  1.000 100.11926 ? 178 VAL F O   1 
ATOM   860  C CB  . VAL A 1 143 ? 175.42049 305.08937 13.13009  1.000 89.01666  ? 178 VAL F CB  1 
ATOM   861  C CG1 . VAL A 1 143 ? 176.40830 305.90956 13.93353  1.000 93.11899  ? 178 VAL F CG1 1 
ATOM   862  C CG2 . VAL A 1 143 ? 174.00798 305.27028 13.68012  1.000 79.21646  ? 178 VAL F CG2 1 
ATOM   863  N N   . VAL A 1 144 ? 177.68270 305.64550 10.67856  1.000 98.32619  ? 179 VAL F N   1 
ATOM   864  C CA  . VAL A 1 144 ? 178.82852 305.16446 9.92056   1.000 96.96663  ? 179 VAL F CA  1 
ATOM   865  C C   . VAL A 1 144 ? 180.11608 305.45720 10.67618  1.000 103.44688 ? 179 VAL F C   1 
ATOM   866  O O   . VAL A 1 144 ? 180.36565 306.60336 11.06447  1.000 108.18498 ? 179 VAL F O   1 
ATOM   867  C CB  . VAL A 1 144 ? 178.85751 305.81002 8.52724   1.000 93.43744  ? 179 VAL F CB  1 
ATOM   868  C CG1 . VAL A 1 144 ? 180.07684 305.34574 7.74161   1.000 101.52849 ? 179 VAL F CG1 1 
ATOM   869  C CG2 . VAL A 1 144 ? 177.56229 305.50050 7.80973   1.000 91.75172  ? 179 VAL F CG2 1 
ATOM   870  N N   . SER A 1 145 ? 180.93383 304.42934 10.88088  1.000 102.23698 ? 180 SER F N   1 
ATOM   871  C CA  . SER A 1 145 ? 182.25391 304.60371 11.47741  1.000 107.74322 ? 180 SER F CA  1 
ATOM   872  C C   . SER A 1 145 ? 183.24961 304.82990 10.34659  1.000 110.14936 ? 180 SER F C   1 
ATOM   873  O O   . SER A 1 145 ? 183.45998 303.94856 9.50681   1.000 108.59557 ? 180 SER F O   1 
ATOM   874  C CB  . SER A 1 145 ? 182.64749 303.41786 12.35475  1.000 112.41220 ? 180 SER F CB  1 
ATOM   875  O OG  . SER A 1 145 ? 181.75511 303.27361 13.44954  1.000 116.06058 ? 180 SER F OG  1 
ATOM   876  N N   . LEU A 1 146 ? 183.76425 306.05343 10.26828  1.000 112.43851 ? 181 LEU F N   1 
ATOM   877  C CA  . LEU A 1 146 ? 184.70079 306.51313 9.25335   1.000 113.15458 ? 181 LEU F CA  1 
ATOM   878  C C   . LEU A 1 146 ? 186.12826 306.03709 9.53578   1.000 116.48098 ? 181 LEU F C   1 
ATOM   879  O O   . LEU A 1 146 ? 186.41116 305.36803 10.53920  1.000 114.69870 ? 181 LEU F O   1 
ATOM   880  C CB  . LEU A 1 146 ? 184.68013 308.03583 9.16998   1.000 116.09644 ? 181 LEU F CB  1 
ATOM   881  C CG  . LEU A 1 146 ? 183.67327 308.68345 8.22247   1.000 114.09314 ? 181 LEU F CG  1 
ATOM   882  C CD1 . LEU A 1 146 ? 182.25147 308.22286 8.55465   1.000 107.61354 ? 181 LEU F CD1 1 
ATOM   883  C CD2 . LEU A 1 146 ? 183.81257 310.20800 8.26358   1.000 106.17261 ? 181 LEU F CD2 1 
ATOM   884  N N   . SER A 1 147 ? 187.04838 306.38339 8.61680   1.000 117.50724 ? 182 SER F N   1 
ATOM   885  C CA  . SER A 1 147 ? 188.45545 306.02734 8.76780   1.000 117.81198 ? 182 SER F CA  1 
ATOM   886  C C   . SER A 1 147 ? 189.20774 307.06936 9.60322   1.000 120.13562 ? 182 SER F C   1 
ATOM   887  O O   . SER A 1 147 ? 190.42953 307.25602 9.44542   1.000 117.03554 ? 182 SER F O   1 
ATOM   888  C CB  . SER A 1 147 ? 189.11707 305.84938 7.39680   1.000 110.63147 ? 182 SER F CB  1 
ATOM   889  O OG  . SER A 1 147 ? 190.53537 305.89640 7.49519   1.000 107.93231 ? 182 SER F OG  1 
ATOM   890  N N   . ASN A 1 148 ? 188.46546 307.76329 10.48827  1.000 118.86139 ? 183 ASN F N   1 
ATOM   891  C CA  . ASN A 1 148 ? 188.99397 308.73113 11.44275  1.000 120.13602 ? 183 ASN F CA  1 
ATOM   892  C C   . ASN A 1 148 ? 188.28557 308.47808 12.77464  1.000 122.52589 ? 183 ASN F C   1 
ATOM   893  O O   . ASN A 1 148 ? 188.38626 309.31633 13.68319  1.000 121.08935 ? 183 ASN F O   1 
ATOM   894  C CB  . ASN A 1 148 ? 188.87865 310.22811 11.06294  1.000 117.20471 ? 183 ASN F CB  1 
ATOM   895  C CG  . ASN A 1 148 ? 187.45035 310.75197 11.09650  1.000 121.71349 ? 183 ASN F CG  1 
ATOM   896  O OD1 . ASN A 1 148 ? 186.49083 310.01694 10.84214  1.000 123.57091 ? 183 ASN F OD1 1 
ATOM   897  N ND2 . ASN A 1 148 ? 187.30123 312.02603 11.48587  1.000 113.05326 ? 183 ASN F ND2 1 
ATOM   898  N N   . GLY A 1 149 ? 187.61108 307.32036 12.91679  1.000 121.66030 ? 184 GLY F N   1 
ATOM   899  C CA  . GLY A 1 149 ? 186.92624 306.87632 14.11746  1.000 118.35215 ? 184 GLY F CA  1 
ATOM   900  C C   . GLY A 1 149 ? 185.49524 307.30858 14.42182  1.000 119.03700 ? 184 GLY F C   1 
ATOM   901  O O   . GLY A 1 149 ? 184.70876 306.48498 14.90922  1.000 112.86022 ? 184 GLY F O   1 
ATOM   902  N N   . PRO A 1 150 ? 185.10852 308.56546 14.16674  1.000 119.72072 ? 185 PRO F N   1 
ATOM   903  C CA  . PRO A 1 150 ? 183.78303 309.00727 14.61413  1.000 114.65542 ? 185 PRO F CA  1 
ATOM   904  C C   . PRO A 1 150 ? 182.66954 308.14092 14.04095  1.000 113.39058 ? 185 PRO F C   1 
ATOM   905  O O   . PRO A 1 150 ? 182.65542 307.79706 12.85273  1.000 107.64658 ? 185 PRO F O   1 
ATOM   906  C CB  . PRO A 1 150 ? 183.69972 310.45311 14.10749  1.000 108.54692 ? 185 PRO F CB  1 
ATOM   907  C CG  . PRO A 1 150 ? 185.10903 310.89125 14.01645  1.000 104.34599 ? 185 PRO F CG  1 
ATOM   908  C CD  . PRO A 1 150 ? 185.80283 309.67216 13.48939  1.000 112.49708 ? 185 PRO F CD  1 
ATOM   909  N N   . SER A 1 151 ? 181.75129 307.76329 14.92240  1.000 111.68052 ? 186 SER F N   1 
ATOM   910  C CA  . SER A 1 151 ? 180.47497 307.15478 14.56109  1.000 109.20721 ? 186 SER F CA  1 
ATOM   911  C C   . SER A 1 151 ? 179.53184 308.28906 14.17027  1.000 108.29210 ? 186 SER F C   1 
ATOM   912  O O   . SER A 1 151 ? 178.82874 308.85572 15.01153  1.000 104.99004 ? 186 SER F O   1 
ATOM   913  C CB  . SER A 1 151 ? 179.91957 306.32329 15.71680  1.000 109.84826 ? 186 SER F CB  1 
ATOM   914  O OG  . SER A 1 151 ? 179.07368 307.10086 16.55675  1.000 105.30619 ? 186 SER F OG  1 
ATOM   915  N N   . VAL A 1 152 ? 179.56530 308.68682 12.88003  1.000 103.10897 ? 187 VAL F N   1 
ATOM   916  C CA  . VAL A 1 152 ? 178.79414 309.84433 12.45204  1.000 96.46786  ? 187 VAL F CA  1 
ATOM   917  C C   . VAL A 1 152 ? 177.45206 309.35726 11.93966  1.000 96.15277  ? 187 VAL F C   1 
ATOM   918  O O   . VAL A 1 152 ? 177.30848 308.23188 11.45496  1.000 99.51909  ? 187 VAL F O   1 
ATOM   919  C CB  . VAL A 1 152 ? 179.52907 310.64193 11.36116  1.000 92.34934  ? 187 VAL F CB  1 
ATOM   920  C CG1 . VAL A 1 152 ? 179.32120 309.97026 9.99480   1.000 90.73243  ? 187 VAL F CG1 1 
ATOM   921  C CG2 . VAL A 1 152 ? 179.01871 312.08049 11.35933  1.000 83.89566  ? 187 VAL F CG2 1 
ATOM   922  N N   . LEU A 1 153 ? 176.46249 310.23156 11.99503  1.000 86.92440  ? 188 LEU F N   1 
ATOM   923  C CA  . LEU A 1 153 ? 175.13386 309.90225 11.50566  1.000 83.74149  ? 188 LEU F CA  1 
ATOM   924  C C   . LEU A 1 153 ? 174.89279 310.51480 10.12756  1.000 89.97156  ? 188 LEU F C   1 
ATOM   925  O O   . LEU A 1 153 ? 174.98241 311.74116 9.97409   1.000 84.94113  ? 188 LEU F O   1 
ATOM   926  C CB  . LEU A 1 153 ? 174.11146 310.41737 12.51767  1.000 76.80632  ? 188 LEU F CB  1 
ATOM   927  C CG  . LEU A 1 153 ? 172.62369 310.23749 12.31636  1.000 81.17200  ? 188 LEU F CG  1 
ATOM   928  C CD1 . LEU A 1 153 ? 171.91601 310.60732 13.61944  1.000 74.12261  ? 188 LEU F CD1 1 
ATOM   929  C CD2 . LEU A 1 153 ? 172.14658 311.09874 11.15966  1.000 87.47453  ? 188 LEU F CD2 1 
ATOM   930  N N   . THR A 1 154 ? 174.63059 309.65819 9.12499   1.000 85.10733  ? 189 THR F N   1 
ATOM   931  C CA  . THR A 1 154 ? 174.43914 310.07055 7.73757   1.000 83.63349  ? 189 THR F CA  1 
ATOM   932  C C   . THR A 1 154 ? 172.95900 309.92484 7.39451   1.000 86.20706  ? 189 THR F C   1 
ATOM   933  O O   . THR A 1 154 ? 172.25647 309.06161 7.93773   1.000 87.28086  ? 189 THR F O   1 
ATOM   934  C CB  . THR A 1 154 ? 175.31505 309.30451 6.72085   1.000 86.26120  ? 189 THR F CB  1 
ATOM   935  O OG1 . THR A 1 154 ? 175.11079 307.89060 6.82702   1.000 93.62308  ? 189 THR F OG1 1 
ATOM   936  C CG2 . THR A 1 154 ? 176.82830 309.68791 6.87393   1.000 83.28366  ? 189 THR F CG2 1 
ATOM   937  N N   . SER A 1 155 ? 172.49960 310.75966 6.46731   1.000 84.31731  ? 190 SER F N   1 
ATOM   938  C CA  . SER A 1 155 ? 171.12695 310.72590 5.98541   1.000 81.39658  ? 190 SER F CA  1 
ATOM   939  C C   . SER A 1 155 ? 171.16516 310.84623 4.47086   1.000 80.25779  ? 190 SER F C   1 
ATOM   940  O O   . SER A 1 155 ? 172.22082 311.07419 3.86522   1.000 74.78349  ? 190 SER F O   1 
ATOM   941  C CB  . SER A 1 155 ? 170.26567 311.84199 6.60577   1.000 77.46553  ? 190 SER F CB  1 
ATOM   942  O OG  . SER A 1 155 ? 170.62944 312.11169 7.95797   1.000 89.14112  ? 190 SER F OG  1 
ATOM   943  N N   . LYS A 1 156 ? 169.99294 310.69655 3.85684   1.000 82.60775  ? 191 LYS F N   1 
ATOM   944  C CA  . LYS A 1 156 ? 169.87574 310.70558 2.39851   1.000 80.38966  ? 191 LYS F CA  1 
ATOM   945  C C   . LYS A 1 156 ? 168.54057 311.35459 2.04442   1.000 72.59152  ? 191 LYS F C   1 
ATOM   946  O O   . LYS A 1 156 ? 167.49229 310.70746 2.09586   1.000 79.20938  ? 191 LYS F O   1 
ATOM   947  C CB  . LYS A 1 156 ? 169.99604 309.29609 1.85772   1.000 83.05402  ? 191 LYS F CB  1 
ATOM   948  C CG  . LYS A 1 156 ? 169.91963 309.21183 0.37812   1.000 86.73218  ? 191 LYS F CG  1 
ATOM   949  C CD  . LYS A 1 156 ? 169.52199 307.80916 0.02855   1.000 95.02500  ? 191 LYS F CD  1 
ATOM   950  C CE  . LYS A 1 156 ? 170.40734 307.30806 -1.07294  1.000 93.32358  ? 191 LYS F CE  1 
ATOM   951  N NZ  . LYS A 1 156 ? 170.04483 305.93922 -1.51984  1.000 95.51329  ? 191 LYS F NZ  1 
ATOM   952  N N   . VAL A 1 157 ? 168.59058 312.65323 1.75464   1.000 71.62394  ? 192 VAL F N   1 
ATOM   953  C CA  . VAL A 1 157 ? 167.38970 313.46224 1.55777   1.000 72.03479  ? 192 VAL F CA  1 
ATOM   954  C C   . VAL A 1 157 ? 166.84802 313.53873 0.12694   1.000 69.15721  ? 192 VAL F C   1 
ATOM   955  O O   . VAL A 1 157 ? 165.71338 314.00533 -0.06066  1.000 63.12998  ? 192 VAL F O   1 
ATOM   956  C CB  . VAL A 1 157 ? 167.67667 314.86828 2.10677   1.000 62.59390  ? 192 VAL F CB  1 
ATOM   957  C CG1 . VAL A 1 157 ? 168.02264 314.74539 3.56456   1.000 64.38082  ? 192 VAL F CG1 1 
ATOM   958  C CG2 . VAL A 1 157 ? 168.83697 315.49715 1.33950   1.000 57.48751  ? 192 VAL F CG2 1 
ATOM   959  N N   . LEU A 1 158 ? 167.64129 313.17284 -0.88615  1.000 69.59267  ? 193 LEU F N   1 
ATOM   960  C CA  . LEU A 1 158 ? 167.19518 313.24856 -2.27329  1.000 66.53943  ? 193 LEU F CA  1 
ATOM   961  C C   . LEU A 1 158 ? 167.87672 312.15197 -3.09090  1.000 74.38476  ? 193 LEU F C   1 
ATOM   962  O O   . LEU A 1 158 ? 169.09643 311.96406 -2.98174  1.000 71.76076  ? 193 LEU F O   1 
ATOM   963  C CB  . LEU A 1 158 ? 167.50791 314.61883 -2.87005  1.000 65.84685  ? 193 LEU F CB  1 
ATOM   964  C CG  . LEU A 1 158 ? 166.94039 314.80496 -4.27008  1.000 69.60983  ? 193 LEU F CG  1 
ATOM   965  C CD1 . LEU A 1 158 ? 165.43959 314.71305 -4.16018  1.000 70.76754  ? 193 LEU F CD1 1 
ATOM   966  C CD2 . LEU A 1 158 ? 167.34625 316.13931 -4.86381  1.000 69.68469  ? 193 LEU F CD2 1 
ATOM   967  N N   . ASP A 1 159 ? 167.11356 311.49211 -3.97415  1.000 77.46012  ? 194 ASP F N   1 
ATOM   968  C CA  . ASP A 1 159 ? 167.63872 310.38244 -4.78200  1.000 75.91231  ? 194 ASP F CA  1 
ATOM   969  C C   . ASP A 1 159 ? 167.40900 310.70402 -6.24611  1.000 74.96742  ? 194 ASP F C   1 
ATOM   970  O O   . ASP A 1 159 ? 166.36800 310.37827 -6.82057  1.000 81.80867  ? 194 ASP F O   1 
ATOM   971  C CB  . ASP A 1 159 ? 167.00392 309.01844 -4.44122  1.000 77.27434  ? 194 ASP F CB  1 
ATOM   972  C CG  . ASP A 1 159 ? 167.82860 307.83235 -4.98315  1.000 84.76344  ? 194 ASP F CG  1 
ATOM   973  O OD1 . ASP A 1 159 ? 168.63441 308.01109 -5.92983  1.000 80.66343  ? 194 ASP F OD1 1 
ATOM   974  O OD2 . ASP A 1 159 ? 167.67733 306.71003 -4.45302  1.000 95.03172  ? 194 ASP F OD2 1 
ATOM   975  N N   . LEU A 1 160 ? 168.39082 311.35719 -6.83835  1.000 71.84274  ? 195 LEU F N   1 
ATOM   976  C CA  . LEU A 1 160 ? 168.34837 311.67772 -8.24703  1.000 71.26226  ? 195 LEU F CA  1 
ATOM   977  C C   . LEU A 1 160 ? 168.91932 310.55813 -9.10087  1.000 73.39000  ? 195 LEU F C   1 
ATOM   978  O O   . LEU A 1 160 ? 168.60170 310.48095 -10.28741 1.000 73.84350  ? 195 LEU F O   1 
ATOM   979  C CB  . LEU A 1 160 ? 169.06925 312.99441 -8.52205  1.000 67.42373  ? 195 LEU F CB  1 
ATOM   980  C CG  . LEU A 1 160 ? 168.29995 314.20605 -7.98296  1.000 73.95398  ? 195 LEU F CG  1 
ATOM   981  C CD1 . LEU A 1 160 ? 169.02229 315.51963 -8.31384  1.000 66.45318  ? 195 LEU F CD1 1 
ATOM   982  C CD2 . LEU A 1 160 ? 166.85355 314.23663 -8.45725  1.000 71.34826  ? 195 LEU F CD2 1 
ATOM   983  N N   . LYS A 1 161 ? 169.80564 309.71781 -8.56376  1.000 73.16279  ? 196 LYS F N   1 
ATOM   984  C CA  . LYS A 1 161 ? 170.30121 308.62585 -9.39293  1.000 83.00899  ? 196 LYS F CA  1 
ATOM   985  C C   . LYS A 1 161 ? 169.19311 307.65809 -9.78089  1.000 81.48588  ? 196 LYS F C   1 
ATOM   986  O O   . LYS A 1 161 ? 169.10201 307.24446 -10.94195 1.000 79.29869  ? 196 LYS F O   1 
ATOM   987  C CB  . LYS A 1 161 ? 171.34669 307.84960 -8.59450  1.000 83.07917  ? 196 LYS F CB  1 
ATOM   988  C CG  . LYS A 1 161 ? 172.01107 306.68268 -9.30835  1.000 85.09486  ? 196 LYS F CG  1 
ATOM   989  C CD  . LYS A 1 161 ? 173.10920 306.11539 -8.43003  1.000 86.38188  ? 196 LYS F CD  1 
ATOM   990  C CE  . LYS A 1 161 ? 174.05066 305.21728 -9.18421  1.000 93.38801  ? 196 LYS F CE  1 
ATOM   991  N NZ  . LYS A 1 161 ? 174.90735 304.45441 -8.21844  1.000 91.26434  ? 196 LYS F NZ  1 
ATOM   992  N N   . ASN A 1 162 ? 168.30562 307.33701 -8.84172  1.000 77.51486  ? 197 ASN F N   1 
ATOM   993  C CA  . ASN A 1 162 ? 167.20307 306.44551 -9.15642  1.000 76.94322  ? 197 ASN F CA  1 
ATOM   994  C C   . ASN A 1 162 ? 166.23228 307.08939 -10.12565 1.000 83.03664  ? 197 ASN F C   1 
ATOM   995  O O   . ASN A 1 162 ? 165.73899 306.43639 -11.05329 1.000 84.85516  ? 197 ASN F O   1 
ATOM   996  C CB  . ASN A 1 162 ? 166.49671 305.95897 -7.90220  1.000 85.00037  ? 197 ASN F CB  1 
ATOM   997  C CG  . ASN A 1 162 ? 166.78115 304.49461 -7.64769  1.000 88.51311  ? 197 ASN F CG  1 
ATOM   998  O OD1 . ASN A 1 162 ? 167.92174 304.04037 -7.82000  1.000 84.85135  ? 197 ASN F OD1 1 
ATOM   999  N ND2 . ASN A 1 162 ? 165.73560 303.72693 -7.33232  1.000 87.01726  ? 197 ASN F ND2 1 
ATOM   1000 N N   . TYR A 1 163 ? 165.98963 308.38538 -9.96438  1.000 76.60405  ? 198 TYR F N   1 
ATOM   1001 C CA  . TYR A 1 163 ? 165.01137 309.01042 -10.83105 1.000 76.18821  ? 198 TYR F CA  1 
ATOM   1002 C C   . TYR A 1 163 ? 165.55938 309.25752 -12.23153 1.000 79.41767  ? 198 TYR F C   1 
ATOM   1003 O O   . TYR A 1 163 ? 164.86911 308.98773 -13.21782 1.000 81.92341  ? 198 TYR F O   1 
ATOM   1004 C CB  . TYR A 1 163 ? 164.59468 310.33570 -10.20486 1.000 68.34609  ? 198 TYR F CB  1 
ATOM   1005 C CG  . TYR A 1 163 ? 163.42282 310.98663 -10.85865 1.000 73.18804  ? 198 TYR F CG  1 
ATOM   1006 C CD1 . TYR A 1 163 ? 162.12431 310.69149 -10.49594 1.000 77.25524  ? 198 TYR F CD1 1 
ATOM   1007 C CD2 . TYR A 1 163 ? 163.62989 311.85636 -11.91574 1.000 70.76706  ? 198 TYR F CD2 1 
ATOM   1008 C CE1 . TYR A 1 163 ? 161.06169 311.29973 -11.13466 1.000 74.42811  ? 198 TYR F CE1 1 
ATOM   1009 C CE2 . TYR A 1 163 ? 162.59026 312.45742 -12.55754 1.000 73.65544  ? 198 TYR F CE2 1 
ATOM   1010 C CZ  . TYR A 1 163 ? 161.30845 312.17583 -12.17303 1.000 73.95741  ? 198 TYR F CZ  1 
ATOM   1011 O OH  . TYR A 1 163 ? 160.27631 312.79541 -12.83516 1.000 80.65297  ? 198 TYR F OH  1 
ATOM   1012 N N   . ILE A 1 164 ? 166.79671 309.71990 -12.37064 1.000 75.05491  ? 199 ILE F N   1 
ATOM   1013 C CA  . ILE A 1 164 ? 167.26398 309.97786 -13.72415 1.000 76.11488  ? 199 ILE F CA  1 
ATOM   1014 C C   . ILE A 1 164 ? 167.52435 308.66657 -14.45162 1.000 79.19323  ? 199 ILE F C   1 
ATOM   1015 O O   . ILE A 1 164 ? 167.10423 308.48953 -15.59764 1.000 81.12074  ? 199 ILE F O   1 
ATOM   1016 C CB  . ILE A 1 164 ? 168.48259 310.91761 -13.75884 1.000 73.07516  ? 199 ILE F CB  1 
ATOM   1017 C CG1 . ILE A 1 164 ? 168.11102 312.32876 -13.28625 1.000 77.87821  ? 199 ILE F CG1 1 
ATOM   1018 C CG2 . ILE A 1 164 ? 169.07301 310.98792 -15.16657 1.000 69.94381  ? 199 ILE F CG2 1 
ATOM   1019 C CD1 . ILE A 1 164 ? 167.95177 312.49984 -11.81128 1.000 74.45587  ? 199 ILE F CD1 1 
ATOM   1020 N N   . ASP A 1 165 ? 168.16486 307.70556 -13.78228 1.000 77.00470  ? 200 ASP F N   1 
ATOM   1021 C CA  . ASP A 1 165 ? 168.54837 306.47697 -14.47163 1.000 85.48185  ? 200 ASP F CA  1 
ATOM   1022 C C   . ASP A 1 165 ? 167.36537 305.56253 -14.74113 1.000 87.97333  ? 200 ASP F C   1 
ATOM   1023 O O   . ASP A 1 165 ? 167.40379 304.76499 -15.68375 1.000 89.26416  ? 200 ASP F O   1 
ATOM   1024 C CB  . ASP A 1 165 ? 169.61497 305.72968 -13.66809 1.000 81.28041  ? 200 ASP F CB  1 
ATOM   1025 C CG  . ASP A 1 165 ? 170.93176 306.48034 -13.60820 1.000 83.23085  ? 200 ASP F CG  1 
ATOM   1026 O OD1 . ASP A 1 165 ? 171.12875 307.38246 -14.44660 1.000 85.90312  ? 200 ASP F OD1 1 
ATOM   1027 O OD2 . ASP A 1 165 ? 171.78293 306.14949 -12.75473 1.000 87.76689  ? 200 ASP F OD2 1 
ATOM   1028 N N   . LYS A 1 166 ? 166.31477 305.66413 -13.94647 1.000 83.11391  ? 201 LYS F N   1 
ATOM   1029 C CA  . LYS A 1 166 ? 165.13666 304.82552 -14.09750 1.000 80.29777  ? 201 LYS F CA  1 
ATOM   1030 C C   . LYS A 1 166 ? 164.02521 305.48081 -14.91184 1.000 87.95183  ? 201 LYS F C   1 
ATOM   1031 O O   . LYS A 1 166 ? 163.41110 304.82077 -15.75352 1.000 89.92072  ? 201 LYS F O   1 
ATOM   1032 C CB  . LYS A 1 166 ? 164.63512 304.38819 -12.72128 1.000 80.98546  ? 201 LYS F CB  1 
ATOM   1033 C CG  . LYS A 1 166 ? 165.54593 303.33071 -12.12867 1.000 79.82753  ? 201 LYS F CG  1 
ATOM   1034 C CD  . LYS A 1 166 ? 165.03794 302.78550 -10.79995 1.000 84.31288  ? 201 LYS F CD  1 
ATOM   1035 C CE  . LYS A 1 166 ? 163.57070 303.09975 -10.55105 1.000 86.27185  ? 201 LYS F CE  1 
ATOM   1036 N NZ  . LYS A 1 166 ? 163.13013 302.54278 -9.23124  1.000 87.07367  ? 201 LYS F NZ  1 
ATOM   1037 N N   . GLN A 1 167 ? 163.80686 306.78500 -14.75320 1.000 87.50783  ? 202 GLN F N   1 
ATOM   1038 C CA  . GLN A 1 167 ? 162.66706 307.45226 -15.36359 1.000 76.21814  ? 202 GLN F CA  1 
ATOM   1039 C C   . GLN A 1 167 ? 163.04077 308.25898 -16.59358 1.000 79.65911  ? 202 GLN F C   1 
ATOM   1040 O O   . GLN A 1 167 ? 162.18072 308.48091 -17.44880 1.000 84.45934  ? 202 GLN F O   1 
ATOM   1041 C CB  . GLN A 1 167 ? 162.08018 308.45568 -14.36894 1.000 79.79016  ? 202 GLN F CB  1 
ATOM   1042 C CG  . GLN A 1 167 ? 160.95994 307.96776 -13.49787 1.000 81.67481  ? 202 GLN F CG  1 
ATOM   1043 C CD  . GLN A 1 167 ? 161.50524 307.00132 -12.46247 1.000 94.65110  ? 202 GLN F CD  1 
ATOM   1044 O OE1 . GLN A 1 167 ? 162.55840 306.38239 -12.67102 1.000 93.00813  ? 202 GLN F OE1 1 
ATOM   1045 N NE2 . GLN A 1 167 ? 160.83893 306.92067 -11.31018 1.000 97.93631  ? 202 GLN F NE2 1 
ATOM   1046 N N   . LEU A 1 168 ? 164.30145 308.66691 -16.70687 1.000 80.38086  ? 203 LEU F N   1 
ATOM   1047 C CA  . LEU A 1 168 ? 164.83244 309.54031 -17.75262 1.000 82.71720  ? 203 LEU F CA  1 
ATOM   1048 C C   . LEU A 1 168 ? 165.74146 308.87686 -18.78664 1.000 86.55268  ? 203 LEU F C   1 
ATOM   1049 O O   . LEU A 1 168 ? 165.66697 309.25988 -19.94509 1.000 89.81449  ? 203 LEU F O   1 
ATOM   1050 C CB  . LEU A 1 168 ? 165.53701 310.76106 -17.12683 1.000 82.28078  ? 203 LEU F CB  1 
ATOM   1051 C CG  . LEU A 1 168 ? 164.70714 311.76833 -16.30022 1.000 79.11686  ? 203 LEU F CG  1 
ATOM   1052 C CD1 . LEU A 1 168 ? 163.87836 312.67167 -17.22282 1.000 76.96567  ? 203 LEU F CD1 1 
ATOM   1053 C CD2 . LEU A 1 168 ? 163.76212 311.07318 -15.36219 1.000 74.44372  ? 203 LEU F CD2 1 
ATOM   1054 N N   . LEU A 1 169 ? 166.68064 307.99818 -18.43551 1.000 86.27980  ? 204 LEU F N   1 
ATOM   1055 C CA  . LEU A 1 169 ? 167.53904 307.40704 -19.46396 1.000 98.67266  ? 204 LEU F CA  1 
ATOM   1056 C C   . LEU A 1 169 ? 166.75588 306.58412 -20.48308 1.000 100.95415 ? 204 LEU F C   1 
ATOM   1057 O O   . LEU A 1 169 ? 167.05726 306.69946 -21.68852 1.000 100.87749 ? 204 LEU F O   1 
ATOM   1058 C CB  . LEU A 1 169 ? 168.69700 306.60145 -18.86661 1.000 96.89964  ? 204 LEU F CB  1 
ATOM   1059 C CG  . LEU A 1 169 ? 169.88027 307.39358 -18.34170 1.000 97.94123  ? 204 LEU F CG  1 
ATOM   1060 C CD1 . LEU A 1 169 ? 170.96950 306.40853 -18.07795 1.000 98.69103  ? 204 LEU F CD1 1 
ATOM   1061 C CD2 . LEU A 1 169 ? 170.28115 308.28016 -19.45279 1.000 100.80852 ? 204 LEU F CD2 1 
ATOM   1062 N N   . PRO A 1 170 ? 165.75674 305.77829 -20.11107 1.000 99.70029  ? 205 PRO F N   1 
ATOM   1063 C CA  . PRO A 1 170 ? 164.97124 305.12271 -21.16670 1.000 101.54622 ? 205 PRO F CA  1 
ATOM   1064 C C   . PRO A 1 170 ? 164.31199 306.14835 -22.07352 1.000 101.42636 ? 205 PRO F C   1 
ATOM   1065 O O   . PRO A 1 170 ? 163.92734 305.81339 -23.20017 1.000 107.05445 ? 205 PRO F O   1 
ATOM   1066 C CB  . PRO A 1 170 ? 163.93442 304.30130 -20.38112 1.000 103.67811 ? 205 PRO F CB  1 
ATOM   1067 C CG  . PRO A 1 170 ? 164.56780 304.09463 -19.02613 1.000 98.27154  ? 205 PRO F CG  1 
ATOM   1068 C CD  . PRO A 1 170 ? 165.32310 305.35887 -18.76026 1.000 95.83076  ? 205 PRO F CD  1 
ATOM   1069 N N   . ILE A 1 171 ? 164.22149 307.40190 -21.62772 1.000 99.45649  ? 206 ILE F N   1 
ATOM   1070 C CA  . ILE A 1 171 ? 163.65600 308.48047 -22.42932 1.000 98.59680  ? 206 ILE F CA  1 
ATOM   1071 C C   . ILE A 1 171 ? 164.71326 309.17713 -23.29073 1.000 102.19717 ? 206 ILE F C   1 
ATOM   1072 O O   . ILE A 1 171 ? 164.36050 309.84986 -24.26887 1.000 103.35194 ? 206 ILE F O   1 
ATOM   1073 C CB  . ILE A 1 171 ? 162.95741 309.50022 -21.51207 1.000 96.32609  ? 206 ILE F CB  1 
ATOM   1074 C CG1 . ILE A 1 171 ? 161.79049 308.82289 -20.78679 1.000 95.27159  ? 206 ILE F CG1 1 
ATOM   1075 C CG2 . ILE A 1 171 ? 162.51622 310.73891 -22.29778 1.000 94.14599  ? 206 ILE F CG2 1 
ATOM   1076 C CD1 . ILE A 1 171 ? 160.81182 309.78261 -20.16490 1.000 91.76032  ? 206 ILE F CD1 1 
ATOM   1077 N N   . VAL A 1 172 ? 165.99851 309.04773 -22.95040 1.000 103.30042 ? 207 VAL F N   1 
ATOM   1078 C CA  . VAL A 1 172 ? 167.06916 309.76256 -23.63702 1.000 108.42114 ? 207 VAL F CA  1 
ATOM   1079 C C   . VAL A 1 172 ? 168.19337 308.84305 -24.08164 1.000 114.15165 ? 207 VAL F C   1 
ATOM   1080 O O   . VAL A 1 172 ? 169.13151 309.30343 -24.73650 1.000 114.90656 ? 207 VAL F O   1 
ATOM   1081 C CB  . VAL A 1 172 ? 167.64364 310.90169 -22.76582 1.000 106.61080 ? 207 VAL F CB  1 
ATOM   1082 C CG1 . VAL A 1 172 ? 168.57448 311.79558 -23.59370 1.000 110.72674 ? 207 VAL F CG1 1 
ATOM   1083 C CG2 . VAL A 1 172 ? 166.52809 311.70728 -22.11036 1.000 97.31905  ? 207 VAL F CG2 1 
ATOM   1084 N N   . ASN A 1 173 ? 168.14140 307.55697 -23.73544 1.000 113.75354 ? 208 ASN F N   1 
ATOM   1085 C CA  . ASN A 1 173 ? 169.19178 306.63455 -24.14330 1.000 121.59085 ? 208 ASN F CA  1 
ATOM   1086 C C   . ASN A 1 173 ? 168.72486 305.69484 -25.24827 1.000 124.64923 ? 208 ASN F C   1 
ATOM   1087 O O   . ASN A 1 173 ? 168.70601 304.47072 -25.06560 1.000 123.11988 ? 208 ASN F O   1 
ATOM   1088 C CB  . ASN A 1 173 ? 169.64675 305.81316 -22.93699 1.000 121.16261 ? 208 ASN F CB  1 
ATOM   1089 C CG  . ASN A 1 173 ? 170.92255 305.05616 -23.20099 1.000 132.11411 ? 208 ASN F CG  1 
ATOM   1090 O OD1 . ASN A 1 173 ? 171.73556 305.46381 -24.03560 1.000 133.31121 ? 208 ASN F OD1 1 
ATOM   1091 N ND2 . ASN A 1 173 ? 171.09295 303.92218 -22.51953 1.000 131.94334 ? 208 ASN F ND2 1 
ATOM   1092 N N   . LYS A 1 174 ? 168.32195 306.26362 -26.38280 1.000 125.19046 ? 209 LYS F N   1 
ATOM   1093 C CA  . LYS A 1 174 ? 167.88130 305.50951 -27.55145 1.000 128.41628 ? 209 LYS F CA  1 
ATOM   1094 C C   . LYS A 1 174 ? 168.43921 306.21560 -28.78869 1.000 133.82025 ? 209 LYS F C   1 
ATOM   1095 O O   . LYS A 1 174 ? 169.21509 307.17274 -28.68058 1.000 133.38351 ? 209 LYS F O   1 
ATOM   1096 C CB  . LYS A 1 174 ? 166.34426 305.44959 -27.53621 1.000 126.75746 ? 209 LYS F CB  1 
ATOM   1097 C CG  . LYS A 1 174 ? 165.69433 304.07252 -27.54634 1.000 119.34323 ? 209 LYS F CG  1 
ATOM   1098 C CD  . LYS A 1 174 ? 164.17817 304.22631 -27.61099 1.000 109.14465 ? 209 LYS F CD  1 
ATOM   1099 C CE  . LYS A 1 174 ? 163.68436 304.86138 -26.31648 1.000 103.09041 ? 209 LYS F CE  1 
ATOM   1100 N NZ  . LYS A 1 174 ? 163.81022 303.90418 -25.17880 1.000 98.08960  ? 209 LYS F NZ  1 
ATOM   1101 N N   . GLN A 1 175 ? 168.05243 305.74181 -29.98029 1.000 136.32048 ? 210 GLN F N   1 
ATOM   1102 C CA  . GLN A 1 175 ? 168.42892 306.45271 -31.20332 1.000 139.70418 ? 210 GLN F CA  1 
ATOM   1103 C C   . GLN A 1 175 ? 167.64394 307.75382 -31.25414 1.000 140.32803 ? 210 GLN F C   1 
ATOM   1104 O O   . GLN A 1 175 ? 168.21024 308.84068 -31.43905 1.000 136.38028 ? 210 GLN F O   1 
ATOM   1105 C CB  . GLN A 1 175 ? 168.17909 305.60571 -32.45606 1.000 136.73163 ? 210 GLN F CB  1 
ATOM   1106 C CG  . GLN A 1 175 ? 169.16131 305.86194 -33.61942 1.000 135.38677 ? 210 GLN F CG  1 
ATOM   1107 C CD  . GLN A 1 175 ? 170.54145 305.26024 -33.42316 1.000 136.79204 ? 210 GLN F CD  1 
ATOM   1108 O OE1 . GLN A 1 175 ? 170.68165 304.08017 -33.10576 1.000 137.90112 ? 210 GLN F OE1 1 
ATOM   1109 N NE2 . GLN A 1 175 ? 171.57236 306.06939 -33.64374 1.000 135.35197 ? 210 GLN F NE2 1 
ATOM   1110 N N   . SER A 1 176 ? 166.32069 307.64229 -31.10885 1.000 143.45157 ? 211 SER F N   1 
ATOM   1111 C CA  . SER A 1 176 ? 165.42509 308.77702 -30.96119 1.000 138.80234 ? 211 SER F CA  1 
ATOM   1112 C C   . SER A 1 176 ? 164.80354 308.70170 -29.56641 1.000 133.06431 ? 211 SER F C   1 
ATOM   1113 O O   . SER A 1 176 ? 164.50879 307.61259 -29.05521 1.000 129.10020 ? 211 SER F O   1 
ATOM   1114 C CB  . SER A 1 176 ? 164.33669 308.77007 -32.04837 1.000 134.80329 ? 211 SER F CB  1 
ATOM   1115 O OG  . SER A 1 176 ? 163.58830 307.56342 -32.01876 1.000 132.22317 ? 211 SER F OG  1 
ATOM   1116 N N   . CYS A 1 177 ? 164.63701 309.86797 -28.95395 1.000 132.16427 ? 212 CYS F N   1 
ATOM   1117 C CA  . CYS A 1 177 ? 164.14556 309.98244 -27.58654 1.000 124.08287 ? 212 CYS F CA  1 
ATOM   1118 C C   . CYS A 1 177 ? 162.69111 309.51562 -27.46806 1.000 115.47648 ? 212 CYS F C   1 
ATOM   1119 O O   . CYS A 1 177 ? 161.85276 309.84685 -28.30968 1.000 116.92415 ? 212 CYS F O   1 
ATOM   1120 C CB  . CYS A 1 177 ? 164.33206 311.42666 -27.11016 1.000 122.68943 ? 212 CYS F CB  1 
ATOM   1121 S SG  . CYS A 1 177 ? 165.95457 312.23212 -27.62032 1.000 140.37508 ? 212 CYS F SG  1 
ATOM   1122 N N   . SER A 1 178 ? 162.38790 308.76292 -26.40541 1.000 109.07309 ? 213 SER F N   1 
ATOM   1123 C CA  . SER A 1 178 ? 161.00445 308.43668 -26.08470 1.000 102.57182 ? 213 SER F CA  1 
ATOM   1124 C C   . SER A 1 178 ? 160.26074 309.62291 -25.45713 1.000 99.00944  ? 213 SER F C   1 
ATOM   1125 O O   . SER A 1 178 ? 160.85196 310.53812 -24.88093 1.000 99.80109  ? 213 SER F O   1 
ATOM   1126 C CB  . SER A 1 178 ? 160.95242 307.24658 -25.12875 1.000 96.75526  ? 213 SER F CB  1 
ATOM   1127 O OG  . SER A 1 178 ? 159.61232 306.86433 -24.87542 1.000 92.61412  ? 213 SER F OG  1 
ATOM   1128 N N   . ILE A 1 179 ? 158.93247 309.58296 -25.56777 1.000 96.01912  ? 214 ILE F N   1 
ATOM   1129 C CA  . ILE A 1 179 ? 158.06429 310.67652 -25.13621 1.000 95.52336  ? 214 ILE F CA  1 
ATOM   1130 C C   . ILE A 1 179 ? 157.71344 310.48477 -23.66296 1.000 93.61468  ? 214 ILE F C   1 
ATOM   1131 O O   . ILE A 1 179 ? 157.00993 309.51073 -23.32625 1.000 91.81062  ? 214 ILE F O   1 
ATOM   1132 C CB  . ILE A 1 179 ? 156.80203 310.83678 -25.99495 1.000 94.29179  ? 214 ILE F CB  1 
ATOM   1133 C CG1 . ILE A 1 179 ? 157.17609 311.61327 -27.24637 1.000 91.66334  ? 214 ILE F CG1 1 
ATOM   1134 C CG2 . ILE A 1 179 ? 155.71406 311.58421 -25.20623 1.000 88.46603  ? 214 ILE F CG2 1 
ATOM   1135 C CD1 . ILE A 1 179 ? 157.75143 312.98463 -26.88020 1.000 93.97144  ? 214 ILE F CD1 1 
ATOM   1136 N N   . PRO A 1 180 ? 158.15518 311.36247 -22.77898 1.000 90.69341  ? 215 PRO F N   1 
ATOM   1137 C CA  . PRO A 1 180 ? 157.72848 311.26235 -21.38961 1.000 88.57264  ? 215 PRO F CA  1 
ATOM   1138 C C   . PRO A 1 180 ? 156.38970 311.94789 -21.19501 1.000 84.93261  ? 215 PRO F C   1 
ATOM   1139 O O   . PRO A 1 180 ? 156.05053 312.92126 -21.86943 1.000 87.12516  ? 215 PRO F O   1 
ATOM   1140 C CB  . PRO A 1 180 ? 158.82536 312.01721 -20.64234 1.000 86.41183  ? 215 PRO F CB  1 
ATOM   1141 C CG  . PRO A 1 180 ? 159.21781 313.09097 -21.62216 1.000 86.09127  ? 215 PRO F CG  1 
ATOM   1142 C CD  . PRO A 1 180 ? 159.05761 312.51135 -23.00264 1.000 90.94767  ? 215 PRO F CD  1 
ATOM   1143 N N   . ASN A 1 181 ? 155.62727 311.42852 -20.24768 1.000 80.46723  ? 216 ASN F N   1 
ATOM   1144 C CA  . ASN A 1 181 ? 154.34006 312.03609 -19.96200 1.000 87.62913  ? 216 ASN F CA  1 
ATOM   1145 C C   . ASN A 1 181 ? 154.57366 313.33028 -19.18419 1.000 87.33188  ? 216 ASN F C   1 
ATOM   1146 O O   . ASN A 1 181 ? 155.63493 313.54556 -18.59288 1.000 87.57895  ? 216 ASN F O   1 
ATOM   1147 C CB  . ASN A 1 181 ? 153.41123 311.05966 -19.22990 1.000 89.17393  ? 216 ASN F CB  1 
ATOM   1148 C CG  . ASN A 1 181 ? 154.09408 310.34564 -18.08069 1.000 95.83505  ? 216 ASN F CG  1 
ATOM   1149 O OD1 . ASN A 1 181 ? 155.29660 310.06005 -18.12990 1.000 96.63880  ? 216 ASN F OD1 1 
ATOM   1150 N ND2 . ASN A 1 181 ? 153.33122 310.05915 -17.03124 1.000 90.86328  ? 216 ASN F ND2 1 
ATOM   1151 N N   . ILE A 1 182 ? 153.57853 314.21840 -19.22553 1.000 88.22601  ? 217 ILE F N   1 
ATOM   1152 C CA  . ILE A 1 182 ? 153.70222 315.52000 -18.57405 1.000 84.77143  ? 217 ILE F CA  1 
ATOM   1153 C C   . ILE A 1 182 ? 153.84970 315.42696 -17.06294 1.000 82.49966  ? 217 ILE F C   1 
ATOM   1154 O O   . ILE A 1 182 ? 154.42432 316.32864 -16.44870 1.000 77.81974  ? 217 ILE F O   1 
ATOM   1155 C CB  . ILE A 1 182 ? 152.46416 316.37688 -18.92827 1.000 88.95639  ? 217 ILE F CB  1 
ATOM   1156 C CG1 . ILE A 1 182 ? 152.74755 317.86255 -18.73425 1.000 88.55341  ? 217 ILE F CG1 1 
ATOM   1157 C CG2 . ILE A 1 182 ? 151.25919 315.95723 -18.09224 1.000 86.19547  ? 217 ILE F CG2 1 
ATOM   1158 C CD1 . ILE A 1 182 ? 153.86264 318.36633 -19.62784 1.000 91.56615  ? 217 ILE F CD1 1 
ATOM   1159 N N   . GLU A 1 183 ? 153.40175 314.33263 -16.44716 1.000 88.94472  ? 218 GLU F N   1 
ATOM   1160 C CA  . GLU A 1 183 ? 153.63045 314.14806 -15.01620 1.000 83.12705  ? 218 GLU F CA  1 
ATOM   1161 C C   . GLU A 1 183 ? 155.11794 314.01961 -14.70682 1.000 79.85361  ? 218 GLU F C   1 
ATOM   1162 O O   . GLU A 1 183 ? 155.59137 314.52797 -13.68822 1.000 72.43974  ? 218 GLU F O   1 
ATOM   1163 C CB  . GLU A 1 183 ? 152.86757 312.92314 -14.50330 1.000 90.10253  ? 218 GLU F CB  1 
ATOM   1164 C CG  . GLU A 1 183 ? 151.33031 313.05160 -14.51101 1.000 101.79609 ? 218 GLU F CG  1 
ATOM   1165 C CD  . GLU A 1 183 ? 150.68993 312.71861 -15.87011 1.000 102.12597 ? 218 GLU F CD  1 
ATOM   1166 O OE1 . GLU A 1 183 ? 151.42473 312.37468 -16.82803 1.000 98.02407  ? 218 GLU F OE1 1 
ATOM   1167 O OE2 . GLU A 1 183 ? 149.44299 312.79053 -15.97331 1.000 107.32154 ? 218 GLU F OE2 1 
ATOM   1168 N N   . THR A 1 184 ? 155.87381 313.36230 -15.58314 1.000 77.58323  ? 219 THR F N   1 
ATOM   1169 C CA  . THR A 1 184 ? 157.31358 313.23907 -15.37642 1.000 75.06696  ? 219 THR F CA  1 
ATOM   1170 C C   . THR A 1 184 ? 158.00960 314.59429 -15.50227 1.000 76.89708  ? 219 THR F C   1 
ATOM   1171 O O   . THR A 1 184 ? 158.95775 314.87699 -14.76312 1.000 75.97214  ? 219 THR F O   1 
ATOM   1172 C CB  . THR A 1 184 ? 157.90548 312.21037 -16.33330 1.000 76.93988  ? 219 THR F CB  1 
ATOM   1173 O OG1 . THR A 1 184 ? 157.34308 310.92187 -16.04698 1.000 77.71673  ? 219 THR F OG1 1 
ATOM   1174 C CG2 . THR A 1 184 ? 159.39958 312.14914 -16.17489 1.000 72.87046  ? 219 THR F CG2 1 
ATOM   1175 N N   . VAL A 1 185 ? 157.58141 315.43652 -16.44203 1.000 74.88909  ? 220 VAL F N   1 
ATOM   1176 C CA  . VAL A 1 185 ? 158.20591 316.75031 -16.57754 1.000 74.96794  ? 220 VAL F CA  1 
ATOM   1177 C C   . VAL A 1 185 ? 158.04550 317.55656 -15.29611 1.000 77.89127  ? 220 VAL F C   1 
ATOM   1178 O O   . VAL A 1 185 ? 158.98929 318.20306 -14.83972 1.000 73.09290  ? 220 VAL F O   1 
ATOM   1179 C CB  . VAL A 1 185 ? 157.60411 317.52436 -17.76225 1.000 78.10912  ? 220 VAL F CB  1 
ATOM   1180 C CG1 . VAL A 1 185 ? 158.20269 318.93545 -17.80206 1.000 75.27373  ? 220 VAL F CG1 1 
ATOM   1181 C CG2 . VAL A 1 185 ? 157.88652 316.78901 -19.06281 1.000 87.28568  ? 220 VAL F CG2 1 
ATOM   1182 N N   . ILE A 1 186 ? 156.86827 317.50415 -14.67343 1.000 75.77615  ? 221 ILE F N   1 
ATOM   1183 C CA  . ILE A 1 186 ? 156.64885 318.27889 -13.45752 1.000 71.93634  ? 221 ILE F CA  1 
ATOM   1184 C C   . ILE A 1 186 ? 157.38570 317.65543 -12.29154 1.000 75.02180  ? 221 ILE F C   1 
ATOM   1185 O O   . ILE A 1 186 ? 157.97576 318.37084 -11.47595 1.000 70.61385  ? 221 ILE F O   1 
ATOM   1186 C CB  . ILE A 1 186 ? 155.14112 318.39117 -13.16695 1.000 69.59933  ? 221 ILE F CB  1 
ATOM   1187 C CG1 . ILE A 1 186 ? 154.45670 319.29221 -14.19069 1.000 71.16386  ? 221 ILE F CG1 1 
ATOM   1188 C CG2 . ILE A 1 186 ? 154.89463 318.93972 -11.75026 1.000 63.44998  ? 221 ILE F CG2 1 
ATOM   1189 C CD1 . ILE A 1 186 ? 152.95923 319.38741 -14.00816 1.000 75.87216  ? 221 ILE F CD1 1 
ATOM   1190 N N   . GLU A 1 187 ? 157.36445 316.32640 -12.18425 1.000 76.24517  ? 222 GLU F N   1 
ATOM   1191 C CA  . GLU A 1 187 ? 158.06907 315.69252 -11.08306 1.000 73.94280  ? 222 GLU F CA  1 
ATOM   1192 C C   . GLU A 1 187 ? 159.56375 315.91521 -11.15817 1.000 72.00413  ? 222 GLU F C   1 
ATOM   1193 O O   . GLU A 1 187 ? 160.21557 316.04787 -10.11879 1.000 73.39429  ? 222 GLU F O   1 
ATOM   1194 C CB  . GLU A 1 187 ? 157.84703 314.18816 -11.06604 1.000 76.16534  ? 222 GLU F CB  1 
ATOM   1195 C CG  . GLU A 1 187 ? 158.16508 313.59072 -9.70529  1.000 83.42472  ? 222 GLU F CG  1 
ATOM   1196 C CD  . GLU A 1 187 ? 157.76505 312.13984 -9.57726  1.000 94.42643  ? 222 GLU F CD  1 
ATOM   1197 O OE1 . GLU A 1 187 ? 157.53933 311.48395 -10.62348 1.000 91.44302  ? 222 GLU F OE1 1 
ATOM   1198 O OE2 . GLU A 1 187 ? 157.70226 311.64897 -8.42860  1.000 100.85239 ? 222 GLU F OE2 1 
ATOM   1199 N N   . PHE A 1 188 ? 160.12087 316.02537 -12.35941 1.000 66.43109  ? 223 PHE F N   1 
ATOM   1200 C CA  . PHE A 1 188 ? 161.55649 316.23283 -12.40737 1.000 67.39307  ? 223 PHE F CA  1 
ATOM   1201 C C   . PHE A 1 188 ? 161.92674 317.66436 -12.08497 1.000 68.97281  ? 223 PHE F C   1 
ATOM   1202 O O   . PHE A 1 188 ? 162.98058 317.90533 -11.49046 1.000 61.20570  ? 223 PHE F O   1 
ATOM   1203 C CB  . PHE A 1 188 ? 162.09400 315.82442 -13.77252 1.000 61.39377  ? 223 PHE F CB  1 
ATOM   1204 C CG  . PHE A 1 188 ? 163.57909 315.88969 -13.88078 1.000 64.28978  ? 223 PHE F CG  1 
ATOM   1205 C CD1 . PHE A 1 188 ? 164.36903 315.31711 -12.89488 1.000 61.76727  ? 223 PHE F CD1 1 
ATOM   1206 C CD2 . PHE A 1 188 ? 164.19289 316.40305 -15.01306 1.000 66.39139  ? 223 PHE F CD2 1 
ATOM   1207 C CE1 . PHE A 1 188 ? 165.74775 315.34090 -12.99779 1.000 65.46039  ? 223 PHE F CE1 1 
ATOM   1208 C CE2 . PHE A 1 188 ? 165.57380 316.42281 -15.12173 1.000 65.79994  ? 223 PHE F CE2 1 
ATOM   1209 C CZ  . PHE A 1 188 ? 166.34984 315.89074 -14.11386 1.000 62.05923  ? 223 PHE F CZ  1 
ATOM   1210 N N   . GLN A 1 189 ? 161.07661 318.62180 -12.43924 1.000 72.44911  ? 224 GLN F N   1 
ATOM   1211 C CA  . GLN A 1 189 ? 161.37568 319.98468 -12.03804 1.000 68.94311  ? 224 GLN F CA  1 
ATOM   1212 C C   . GLN A 1 189 ? 161.25957 320.15899 -10.53594 1.000 69.06324  ? 224 GLN F C   1 
ATOM   1213 O O   . GLN A 1 189 ? 162.02425 320.93267 -9.95687  1.000 67.79292  ? 224 GLN F O   1 
ATOM   1214 C CB  . GLN A 1 189 ? 160.46807 320.96127 -12.77837 1.000 61.61057  ? 224 GLN F CB  1 
ATOM   1215 C CG  . GLN A 1 189 ? 160.77783 321.00436 -14.26674 1.000 76.80782  ? 224 GLN F CG  1 
ATOM   1216 C CD  . GLN A 1 189 ? 159.83992 321.88194 -15.07343 1.000 78.51691  ? 224 GLN F CD  1 
ATOM   1217 O OE1 . GLN A 1 189 ? 158.84036 322.39738 -14.55501 1.000 75.66496  ? 224 GLN F OE1 1 
ATOM   1218 N NE2 . GLN A 1 189 ? 160.21319 322.13240 -16.33269 1.000 72.75847  ? 224 GLN F NE2 1 
ATOM   1219 N N   . GLN A 1 190 ? 160.36773 319.40474 -9.88450  1.000 71.17298  ? 225 GLN F N   1 
ATOM   1220 C CA  . GLN A 1 190 ? 160.24194 319.48979 -8.43306  1.000 67.14648  ? 225 GLN F CA  1 
ATOM   1221 C C   . GLN A 1 190 ? 161.43152 318.85380 -7.72380  1.000 68.61195  ? 225 GLN F C   1 
ATOM   1222 O O   . GLN A 1 190 ? 161.97043 319.42667 -6.77204  1.000 69.56111  ? 225 GLN F O   1 
ATOM   1223 C CB  . GLN A 1 190 ? 158.94873 318.83099 -7.96978  1.000 73.38768  ? 225 GLN F CB  1 
ATOM   1224 C CG  . GLN A 1 190 ? 157.71003 319.46359 -8.55447  1.000 79.81410  ? 225 GLN F CG  1 
ATOM   1225 C CD  . GLN A 1 190 ? 157.47509 320.87380 -8.07630  1.000 83.35949  ? 225 GLN F CD  1 
ATOM   1226 O OE1 . GLN A 1 190 ? 157.16294 321.11452 -6.90424  1.000 80.22566  ? 225 GLN F OE1 1 
ATOM   1227 N NE2 . GLN A 1 190 ? 157.61792 321.82745 -8.99661  1.000 79.56538  ? 225 GLN F NE2 1 
ATOM   1228 N N   . LYS A 1 191 ? 161.85811 317.66856 -8.16933  1.000 69.57880  ? 226 LYS F N   1 
ATOM   1229 C CA  . LYS A 1 191 ? 162.99193 317.01185 -7.52015  1.000 67.64189  ? 226 LYS F CA  1 
ATOM   1230 C C   . LYS A 1 191 ? 164.29819 317.72905 -7.80357  1.000 68.42789  ? 226 LYS F C   1 
ATOM   1231 O O   . LYS A 1 191 ? 165.11658 317.90587 -6.89638  1.000 69.50606  ? 226 LYS F O   1 
ATOM   1232 C CB  . LYS A 1 191 ? 163.09982 315.52980 -7.88828  1.000 66.77397  ? 226 LYS F CB  1 
ATOM   1233 C CG  . LYS A 1 191 ? 162.14024 314.62994 -7.13419  1.000 76.55403  ? 226 LYS F CG  1 
ATOM   1234 C CD  . LYS A 1 191 ? 162.61513 313.15799 -7.19310  1.000 80.71340  ? 226 LYS F CD  1 
ATOM   1235 C CE  . LYS A 1 191 ? 161.84973 312.26967 -6.20308  1.000 80.69811  ? 226 LYS F CE  1 
ATOM   1236 N NZ  . LYS A 1 191 ? 160.49154 311.87796 -6.62771  1.000 85.68364  ? 226 LYS F NZ  1 
ATOM   1237 N N   . ASN A 1 192 ? 164.50062 318.18609 -9.03603  1.000 67.09447  ? 227 ASN F N   1 
ATOM   1238 C CA  . ASN A 1 192 ? 165.76439 318.82890 -9.36233  1.000 63.33803  ? 227 ASN F CA  1 
ATOM   1239 C C   . ASN A 1 192 ? 165.87972 320.18554 -8.66984  1.000 68.48834  ? 227 ASN F C   1 
ATOM   1240 O O   . ASN A 1 192 ? 166.98515 320.72318 -8.56364  1.000 65.70878  ? 227 ASN F O   1 
ATOM   1241 C CB  . ASN A 1 192 ? 165.88990 319.02849 -10.86705 1.000 55.45811  ? 227 ASN F CB  1 
ATOM   1242 C CG  . ASN A 1 192 ? 167.28844 319.39701 -11.29105 1.000 62.36398  ? 227 ASN F CG  1 
ATOM   1243 O OD1 . ASN A 1 192 ? 168.25639 318.96100 -10.66900 1.000 67.27257  ? 227 ASN F OD1 1 
ATOM   1244 N ND2 . ASN A 1 192 ? 167.41378 320.22413 -12.33076 1.000 63.47999  ? 227 ASN F ND2 1 
ATOM   1245 N N   . ASN A 1 193 ? 164.76193 320.73024 -8.18067  1.000 62.94989  ? 228 ASN F N   1 
ATOM   1246 C CA  . ASN A 1 193 ? 164.75529 322.06892 -7.60898  1.000 62.60851  ? 228 ASN F CA  1 
ATOM   1247 C C   . ASN A 1 193 ? 165.64261 322.15978 -6.37107  1.000 63.46253  ? 228 ASN F C   1 
ATOM   1248 O O   . ASN A 1 193 ? 166.45664 323.07938 -6.25054  1.000 61.74494  ? 228 ASN F O   1 
ATOM   1249 C CB  . ASN A 1 193 ? 163.33508 322.44237 -7.19428  1.000 60.70790  ? 228 ASN F CB  1 
ATOM   1250 C CG  . ASN A 1 193 ? 163.25392 323.83867 -6.60412  1.000 63.14919  ? 228 ASN F CG  1 
ATOM   1251 O OD1 . ASN A 1 193 ? 163.81209 324.78628 -7.14477  1.000 63.50353  ? 228 ASN F OD1 1 
ATOM   1252 N ND2 . ASN A 1 193 ? 162.69880 323.93168 -5.40107  1.000 69.50291  ? 228 ASN F ND2 1 
ATOM   1253 N N   . ARG A 1 194 ? 165.55320 321.17724 -5.47606  1.000 62.23119  ? 229 ARG F N   1 
ATOM   1254 C CA  . ARG A 1 194 ? 166.33564 321.24017 -4.25229  1.000 56.30664  ? 229 ARG F CA  1 
ATOM   1255 C C   . ARG A 1 194 ? 167.81546 321.22314 -4.55046  1.000 64.12780  ? 229 ARG F C   1 
ATOM   1256 O O   . ARG A 1 194 ? 168.59595 321.88588 -3.86201  1.000 65.87636  ? 229 ARG F O   1 
ATOM   1257 C CB  . ARG A 1 194 ? 165.97141 320.07393 -3.32482  1.000 58.95892  ? 229 ARG F CB  1 
ATOM   1258 C CG  . ARG A 1 194 ? 166.59649 320.15405 -1.92681  1.000 59.47631  ? 229 ARG F CG  1 
ATOM   1259 C CD  . ARG A 1 194 ? 166.13453 319.03140 -1.00261  1.000 61.67854  ? 229 ARG F CD  1 
ATOM   1260 N NE  . ARG A 1 194 ? 166.66434 319.19859 0.34364   1.000 56.55123  ? 229 ARG F NE  1 
ATOM   1261 C CZ  . ARG A 1 194 ? 166.43481 318.39467 1.37355   1.000 63.34195  ? 229 ARG F CZ  1 
ATOM   1262 N NH1 . ARG A 1 194 ? 165.67091 317.32278 1.26198   1.000 67.42592  ? 229 ARG F NH1 1 
ATOM   1263 N NH2 . ARG A 1 194 ? 166.98173 318.68012 2.55339   1.000 60.47074  ? 229 ARG F NH2 1 
ATOM   1264 N N   . LEU A 1 195 ? 168.21754 320.50980 -5.59211  1.000 62.08294  ? 230 LEU F N   1 
ATOM   1265 C CA  . LEU A 1 195 ? 169.61627 320.52237 -5.97877  1.000 56.69259  ? 230 LEU F CA  1 
ATOM   1266 C C   . LEU A 1 195 ? 170.04686 321.90005 -6.44811  1.000 58.96754  ? 230 LEU F C   1 
ATOM   1267 O O   . LEU A 1 195 ? 171.14902 322.35160 -6.12966  1.000 64.13835  ? 230 LEU F O   1 
ATOM   1268 C CB  . LEU A 1 195 ? 169.86518 319.50535 -7.08048  1.000 56.96412  ? 230 LEU F CB  1 
ATOM   1269 C CG  . LEU A 1 195 ? 171.28028 319.51510 -7.63079  1.000 61.25896  ? 230 LEU F CG  1 
ATOM   1270 C CD1 . LEU A 1 195 ? 172.24222 319.15727 -6.50416  1.000 55.39079  ? 230 LEU F CD1 1 
ATOM   1271 C CD2 . LEU A 1 195 ? 171.39555 318.56928 -8.82515  1.000 61.78398  ? 230 LEU F CD2 1 
ATOM   1272 N N   . LEU A 1 196 ? 169.22348 322.56511 -7.24890  1.000 58.70334  ? 231 LEU F N   1 
ATOM   1273 C CA  . LEU A 1 196 ? 169.64452 323.86241 -7.75996  1.000 65.52209  ? 231 LEU F CA  1 
ATOM   1274 C C   . LEU A 1 196 ? 169.76863 324.90042 -6.63795  1.000 60.70072  ? 231 LEU F C   1 
ATOM   1275 O O   . LEU A 1 196 ? 170.71430 325.69471 -6.63510  1.000 65.72122  ? 231 LEU F O   1 
ATOM   1276 C CB  . LEU A 1 196 ? 168.66635 324.31152 -8.85059  1.000 59.38982  ? 231 LEU F CB  1 
ATOM   1277 C CG  . LEU A 1 196 ? 168.47628 323.27997 -9.98049  1.000 64.31078  ? 231 LEU F CG  1 
ATOM   1278 C CD1 . LEU A 1 196 ? 167.58799 323.79246 -11.11871 1.000 57.90934  ? 231 LEU F CD1 1 
ATOM   1279 C CD2 . LEU A 1 196 ? 169.81114 322.84351 -10.53843 1.000 61.44560  ? 231 LEU F CD2 1 
ATOM   1280 N N   . GLU A 1 197 ? 168.86765 324.88808 -5.65427  1.000 57.27730  ? 232 GLU F N   1 
ATOM   1281 C CA  . GLU A 1 197 ? 168.99414 325.87617 -4.58691  1.000 65.87982  ? 232 GLU F CA  1 
ATOM   1282 C C   . GLU A 1 197 ? 170.15994 325.58499 -3.66277  1.000 61.40756  ? 232 GLU F C   1 
ATOM   1283 O O   . GLU A 1 197 ? 170.85430 326.51344 -3.24489  1.000 58.12513  ? 232 GLU F O   1 
ATOM   1284 C CB  . GLU A 1 197 ? 167.71108 326.00766 -3.77063  1.000 65.83346  ? 232 GLU F CB  1 
ATOM   1285 C CG  . GLU A 1 197 ? 166.57704 326.53980 -4.59003  1.000 74.51930  ? 232 GLU F CG  1 
ATOM   1286 C CD  . GLU A 1 197 ? 166.80217 328.04025 -4.85193  1.000 85.17223  ? 232 GLU F CD  1 
ATOM   1287 O OE1 . GLU A 1 197 ? 167.75247 328.61801 -4.23150  1.000 81.59956  ? 232 GLU F OE1 1 
ATOM   1288 O OE2 . GLU A 1 197 ? 166.05356 328.63073 -5.66934  1.000 76.37959  ? 232 GLU F OE2 1 
ATOM   1289 N N   . ILE A 1 198 ? 170.47413 324.31601 -3.44606  1.000 63.30043  ? 233 ILE F N   1 
ATOM   1290 C CA  . ILE A 1 198 ? 171.60186 324.00890 -2.59296  1.000 53.88151  ? 233 ILE F CA  1 
ATOM   1291 C C   . ILE A 1 198 ? 172.87802 324.41283 -3.29143  1.000 57.58926  ? 233 ILE F C   1 
ATOM   1292 O O   . ILE A 1 198 ? 173.77023 325.01592 -2.67294  1.000 54.01254  ? 233 ILE F O   1 
ATOM   1293 C CB  . ILE A 1 198 ? 171.60064 322.50947 -2.23723  1.000 53.88805  ? 233 ILE F CB  1 
ATOM   1294 C CG1 . ILE A 1 198 ? 170.45675 322.17087 -1.28444  1.000 56.75720  ? 233 ILE F CG1 1 
ATOM   1295 C CG2 . ILE A 1 198 ? 172.93281 322.05661 -1.70985  1.000 55.31047  ? 233 ILE F CG2 1 
ATOM   1296 C CD1 . ILE A 1 198 ? 170.38218 320.69951 -0.99396  1.000 48.76884  ? 233 ILE F CD1 1 
ATOM   1297 N N   . THR A 1 199 ? 172.96238 324.14923 -4.59656  1.000 54.94314  ? 234 THR F N   1 
ATOM   1298 C CA  . THR A 1 199 ? 174.12709 324.58550 -5.34907  1.000 61.84686  ? 234 THR F CA  1 
ATOM   1299 C C   . THR A 1 199 ? 174.24057 326.10205 -5.38488  1.000 56.69726  ? 234 THR F C   1 
ATOM   1300 O O   . THR A 1 199 ? 175.34916 326.63625 -5.31724  1.000 55.91181  ? 234 THR F O   1 
ATOM   1301 C CB  . THR A 1 199 ? 174.05476 324.02653 -6.77472  1.000 59.42297  ? 234 THR F CB  1 
ATOM   1302 O OG1 . THR A 1 199 ? 173.54493 322.68822 -6.72773  1.000 61.82994  ? 234 THR F OG1 1 
ATOM   1303 C CG2 . THR A 1 199 ? 175.43558 324.01569 -7.43874  1.000 59.43018  ? 234 THR F CG2 1 
ATOM   1304 N N   . ARG A 1 200 ? 173.12014 326.81427 -5.40242  1.000 48.42731  ? 235 ARG F N   1 
ATOM   1305 C CA  . ARG A 1 200 ? 173.21027 328.26641 -5.40212  1.000 58.97441  ? 235 ARG F CA  1 
ATOM   1306 C C   . ARG A 1 200 ? 173.79999 328.78430 -4.09260  1.000 57.73825  ? 235 ARG F C   1 
ATOM   1307 O O   . ARG A 1 200 ? 174.71489 329.61954 -4.09799  1.000 56.20506  ? 235 ARG F O   1 
ATOM   1308 C CB  . ARG A 1 200 ? 171.85139 328.91163 -5.59718  1.000 58.03141  ? 235 ARG F CB  1 
ATOM   1309 C CG  . ARG A 1 200 ? 171.99464 330.33433 -6.07455  1.000 65.24765  ? 235 ARG F CG  1 
ATOM   1310 C CD  . ARG A 1 200 ? 170.63846 330.96545 -6.30143  1.000 66.42699  ? 235 ARG F CD  1 
ATOM   1311 N NE  . ARG A 1 200 ? 169.89459 330.84660 -5.04241  1.000 76.60732  ? 235 ARG F NE  1 
ATOM   1312 C CZ  . ARG A 1 200 ? 170.23148 331.43753 -3.89070  1.000 85.28637  ? 235 ARG F CZ  1 
ATOM   1313 N NH1 . ARG A 1 200 ? 171.31143 332.20792 -3.78556  1.000 73.45046  ? 235 ARG F NH1 1 
ATOM   1314 N NH2 . ARG A 1 200 ? 169.47722 331.23611 -2.80590  1.000 80.77953  ? 235 ARG F NH2 1 
ATOM   1315 N N   . GLU A 1 201 ? 173.33012 328.24902 -2.95522  1.000 52.12764  ? 236 GLU F N   1 
ATOM   1316 C CA  . GLU A 1 201 ? 173.83988 328.73563 -1.68047  1.000 56.35276  ? 236 GLU F CA  1 
ATOM   1317 C C   . GLU A 1 201 ? 175.30243 328.36026 -1.49347  1.000 50.82777  ? 236 GLU F C   1 
ATOM   1318 O O   . GLU A 1 201 ? 176.08581 329.16855 -0.99287  1.000 54.65780  ? 236 GLU F O   1 
ATOM   1319 C CB  . GLU A 1 201 ? 173.04383 328.19600 -0.48810  1.000 52.00535  ? 236 GLU F CB  1 
ATOM   1320 C CG  . GLU A 1 201 ? 171.54816 328.42937 -0.43338  1.000 49.22490  ? 236 GLU F CG  1 
ATOM   1321 C CD  . GLU A 1 201 ? 170.97867 327.89459 0.89091   1.000 61.37013  ? 236 GLU F CD  1 
ATOM   1322 O OE1 . GLU A 1 201 ? 171.77681 327.66948 1.82958   1.000 70.25602  ? 236 GLU F OE1 1 
ATOM   1323 O OE2 . GLU A 1 201 ? 169.76622 327.63114 1.00588   1.000 61.25104  ? 236 GLU F OE2 1 
ATOM   1324 N N   . PHE A 1 202 ? 175.69182 327.14179 -1.85590  1.000 49.80982  ? 237 PHE F N   1 
ATOM   1325 C CA  . PHE A 1 202 ? 177.08110 326.75645 -1.65424  1.000 53.27930  ? 237 PHE F CA  1 
ATOM   1326 C C   . PHE A 1 202 ? 178.01184 327.51622 -2.58990  1.000 58.74466  ? 237 PHE F C   1 
ATOM   1327 O O   . PHE A 1 202 ? 179.15073 327.84053 -2.21945  1.000 57.14064  ? 237 PHE F O   1 
ATOM   1328 C CB  . PHE A 1 202 ? 177.24715 325.25969 -1.87306  1.000 51.68891  ? 237 PHE F CB  1 
ATOM   1329 C CG  . PHE A 1 202 ? 176.94550 324.45038 -0.66595  1.000 56.67693  ? 237 PHE F CG  1 
ATOM   1330 C CD1 . PHE A 1 202 ? 177.14186 324.98031 0.60317   1.000 56.34243  ? 237 PHE F CD1 1 
ATOM   1331 C CD2 . PHE A 1 202 ? 176.44765 323.15891 -0.78900  1.000 50.73985  ? 237 PHE F CD2 1 
ATOM   1332 C CE1 . PHE A 1 202 ? 176.84236 324.23168 1.74921   1.000 54.73208  ? 237 PHE F CE1 1 
ATOM   1333 C CE2 . PHE A 1 202 ? 176.16465 322.40180 0.33786   1.000 57.60558  ? 237 PHE F CE2 1 
ATOM   1334 C CZ  . PHE A 1 202 ? 176.35630 322.94052 1.61258   1.000 58.44866  ? 237 PHE F CZ  1 
ATOM   1335 N N   . SER A 1 203 ? 177.51145 327.90708 -3.75780  1.000 56.94450  ? 238 SER F N   1 
ATOM   1336 C CA  . SER A 1 203 ? 178.35926 328.60472 -4.70991  1.000 58.91429  ? 238 SER F CA  1 
ATOM   1337 C C   . SER A 1 203 ? 178.60072 330.04684 -4.30224  1.000 57.26829  ? 238 SER F C   1 
ATOM   1338 O O   . SER A 1 203 ? 179.73500 330.52985 -4.39503  1.000 60.84023  ? 238 SER F O   1 
ATOM   1339 C CB  . SER A 1 203 ? 177.72580 328.53739 -6.09775  1.000 60.54264  ? 238 SER F CB  1 
ATOM   1340 O OG  . SER A 1 203 ? 177.62224 327.17644 -6.51335  1.000 63.29658  ? 238 SER F OG  1 
ATOM   1341 N N   . VAL A 1 204 ? 177.55692 330.75870 -3.87177  1.000 54.29775  ? 239 VAL F N   1 
ATOM   1342 C CA  . VAL A 1 204 ? 177.73908 332.17143 -3.53577  1.000 62.71200  ? 239 VAL F CA  1 
ATOM   1343 C C   . VAL A 1 204 ? 178.46396 332.36959 -2.20222  1.000 59.69127  ? 239 VAL F C   1 
ATOM   1344 O O   . VAL A 1 204 ? 178.97159 333.45854 -1.93758  1.000 66.58973  ? 239 VAL F O   1 
ATOM   1345 C CB  . VAL A 1 204 ? 176.39235 332.91693 -3.58543  1.000 66.34550  ? 239 VAL F CB  1 
ATOM   1346 C CG1 . VAL A 1 204 ? 175.76484 332.76040 -4.99017  1.000 57.87197  ? 239 VAL F CG1 1 
ATOM   1347 C CG2 . VAL A 1 204 ? 175.44774 332.44201 -2.49587  1.000 64.34095  ? 239 VAL F CG2 1 
ATOM   1348 N N   . ASN A 1 205 ? 178.51196 331.34910 -1.35424  1.000 56.92374  ? 240 ASN F N   1 
ATOM   1349 C CA  . ASN A 1 205 ? 179.08577 331.41638 -0.01917  1.000 53.42003  ? 240 ASN F CA  1 
ATOM   1350 C C   . ASN A 1 205 ? 180.32311 330.54490 0.13497   1.000 57.53958  ? 240 ASN F C   1 
ATOM   1351 O O   . ASN A 1 205 ? 180.68131 330.17559 1.25541   1.000 56.11821  ? 240 ASN F O   1 
ATOM   1352 C CB  . ASN A 1 205 ? 178.00722 331.01821 0.98406   1.000 54.82724  ? 240 ASN F CB  1 
ATOM   1353 C CG  . ASN A 1 205 ? 176.83456 331.99429 0.97139   1.000 60.35723  ? 240 ASN F CG  1 
ATOM   1354 O OD1 . ASN A 1 205 ? 175.66697 331.59321 0.93442   1.000 61.64745  ? 240 ASN F OD1 1 
ATOM   1355 N ND2 . ASN A 1 205 ? 177.14351 333.28380 1.01676   1.000 64.80511  ? 240 ASN F ND2 1 
ATOM   1356 N N   . ALA A 1 206 ? 180.94567 330.14521 -0.96753  1.000 55.70183  ? 241 ALA F N   1 
ATOM   1357 C CA  . ALA A 1 206 ? 182.19641 329.39840 -0.89690  1.000 59.16362  ? 241 ALA F CA  1 
ATOM   1358 C C   . ALA A 1 206 ? 182.05872 328.11594 -0.07800  1.000 59.23155  ? 241 ALA F C   1 
ATOM   1359 O O   . ALA A 1 206 ? 182.97479 327.71217 0.63698   1.000 60.12682  ? 241 ALA F O   1 
ATOM   1360 C CB  . ALA A 1 206 ? 183.30527 330.27050 -0.30954  1.000 64.04307  ? 241 ALA F CB  1 
ATOM   1361 N N   . GLY A 1 207 ? 180.95232 327.40624 -0.24955  1.000 54.12201  ? 242 GLY F N   1 
ATOM   1362 C CA  . GLY A 1 207 ? 180.81306 326.12775 0.41236   1.000 52.12290  ? 242 GLY F CA  1 
ATOM   1363 C C   . GLY A 1 207 ? 180.40322 326.11507 1.86801   1.000 49.43630  ? 242 GLY F C   1 
ATOM   1364 O O   . GLY A 1 207 ? 180.32102 325.01375 2.43222   1.000 53.51838  ? 242 GLY F O   1 
ATOM   1365 N N   . VAL A 1 208 ? 180.30766 327.27578 2.53347   1.000 53.02027  ? 243 VAL F N   1 
ATOM   1366 C CA  . VAL A 1 208 ? 179.92775 327.41270 3.95301   1.000 49.84210  ? 243 VAL F CA  1 
ATOM   1367 C C   . VAL A 1 208 ? 178.75611 328.38422 4.14636   1.000 48.74885  ? 243 VAL F C   1 
ATOM   1368 O O   . VAL A 1 208 ? 178.89043 329.57652 3.85669   1.000 57.96869  ? 243 VAL F O   1 
ATOM   1369 C CB  . VAL A 1 208 ? 181.12798 327.85064 4.81387   1.000 54.82626  ? 243 VAL F CB  1 
ATOM   1370 C CG1 . VAL A 1 208 ? 180.76266 327.86158 6.29113   1.000 45.39690  ? 243 VAL F CG1 1 
ATOM   1371 C CG2 . VAL A 1 208 ? 182.30047 326.93061 4.56804   1.000 47.82727  ? 243 VAL F CG2 1 
ATOM   1372 N N   . THR A 1 209 ? 177.58658 327.87879 4.51175   1.000 43.78696  ? 244 THR F N   1 
ATOM   1373 C CA  . THR A 1 209 ? 176.41112 328.72885 4.66832   1.000 46.88096  ? 244 THR F CA  1 
ATOM   1374 C C   . THR A 1 209 ? 175.92107 328.76288 6.11417   1.000 49.50796  ? 244 THR F C   1 
ATOM   1375 O O   . THR A 1 209 ? 176.10396 327.79854 6.86771   1.000 48.41827  ? 244 THR F O   1 
ATOM   1376 C CB  . THR A 1 209 ? 175.23876 328.29703 3.74841   1.000 49.37604  ? 244 THR F CB  1 
ATOM   1377 O OG1 . THR A 1 209 ? 174.71963 327.03526 4.18169   1.000 54.77786  ? 244 THR F OG1 1 
ATOM   1378 C CG2 . THR A 1 209 ? 175.71205 328.16624 2.29423   1.000 49.30712  ? 244 THR F CG2 1 
ATOM   1379 N N   . THR A 1 210 ? 175.43254 329.92384 6.54695   1.000 50.91838  ? 245 THR F N   1 
ATOM   1380 C CA  . THR A 1 210 ? 174.78836 330.01348 7.85858   1.000 46.52971  ? 245 THR F CA  1 
ATOM   1381 C C   . THR A 1 210 ? 173.92146 331.26553 7.71292   1.000 46.44710  ? 245 THR F C   1 
ATOM   1382 O O   . THR A 1 210 ? 174.35941 332.23857 7.08930   1.000 51.76173  ? 245 THR F O   1 
ATOM   1383 C CB  . THR A 1 210 ? 175.75236 330.10607 9.05549   1.000 47.57730  ? 245 THR F CB  1 
ATOM   1384 O OG1 . THR A 1 210 ? 174.98870 330.32573 10.24343  1.000 43.12640  ? 245 THR F OG1 1 
ATOM   1385 C CG2 . THR A 1 210 ? 176.67223 331.31137 8.91175   1.000 44.40447  ? 245 THR F CG2 1 
ATOM   1386 N N   . PRO A 1 211 ? 172.65577 331.24408 8.12661   1.000 41.46647  ? 246 PRO F N   1 
ATOM   1387 C CA  . PRO A 1 211 ? 171.99746 330.09131 8.74035   1.000 43.84669  ? 246 PRO F CA  1 
ATOM   1388 C C   . PRO A 1 211 ? 171.74998 328.92610 7.77449   1.000 49.66736  ? 246 PRO F C   1 
ATOM   1389 O O   . PRO A 1 211 ? 171.94093 329.04301 6.56321   1.000 47.61354  ? 246 PRO F O   1 
ATOM   1390 C CB  . PRO A 1 211 ? 170.64162 330.66396 9.20066   1.000 45.13712  ? 246 PRO F CB  1 
ATOM   1391 C CG  . PRO A 1 211 ? 170.80684 332.17017 9.16549   1.000 49.98991  ? 246 PRO F CG  1 
ATOM   1392 C CD  . PRO A 1 211 ? 171.76802 332.41633 8.04207   1.000 42.26137  ? 246 PRO F CD  1 
ATOM   1393 N N   . VAL A 1 212 ? 171.35282 327.78794 8.33964   1.000 47.90993  ? 247 VAL F N   1 
ATOM   1394 C CA  . VAL A 1 212 ? 171.04485 326.59219 7.56116   1.000 52.53872  ? 247 VAL F CA  1 
ATOM   1395 C C   . VAL A 1 212 ? 169.58667 326.67942 7.08693   1.000 48.42938  ? 247 VAL F C   1 
ATOM   1396 O O   . VAL A 1 212 ? 168.65922 326.71228 7.90236   1.000 49.72085  ? 247 VAL F O   1 
ATOM   1397 C CB  . VAL A 1 212 ? 171.31194 325.32704 8.37095   1.000 53.00852  ? 247 VAL F CB  1 
ATOM   1398 C CG1 . VAL A 1 212 ? 170.92052 324.09772 7.57576   1.000 54.27267  ? 247 VAL F CG1 1 
ATOM   1399 C CG2 . VAL A 1 212 ? 172.78192 325.31484 8.80107   1.000 49.51407  ? 247 VAL F CG2 1 
ATOM   1400 N N   . SER A 1 213 ? 169.39069 326.78471 5.77372   1.000 47.02319  ? 248 SER F N   1 
ATOM   1401 C CA  . SER A 1 213 ? 168.08447 326.93893 5.14028   1.000 51.45537  ? 248 SER F CA  1 
ATOM   1402 C C   . SER A 1 213 ? 167.30341 325.61753 5.10404   1.000 53.38838  ? 248 SER F C   1 
ATOM   1403 O O   . SER A 1 213 ? 167.83031 324.52696 5.38177   1.000 50.03910  ? 248 SER F O   1 
ATOM   1404 C CB  . SER A 1 213 ? 168.23940 327.41700 3.70907   1.000 47.29394  ? 248 SER F CB  1 
ATOM   1405 O OG  . SER A 1 213 ? 168.94590 326.43763 2.95683   1.000 52.31682  ? 248 SER F OG  1 
ATOM   1406 N N   . THR A 1 214 ? 166.01379 325.73544 4.75887   1.000 52.76973  ? 249 THR F N   1 
ATOM   1407 C CA  . THR A 1 214 ? 165.14912 324.56665 4.56950   1.000 54.95242  ? 249 THR F CA  1 
ATOM   1408 C C   . THR A 1 214 ? 165.56883 323.74312 3.35209   1.000 57.57752  ? 249 THR F C   1 
ATOM   1409 O O   . THR A 1 214 ? 165.18112 322.57264 3.24428   1.000 61.48977  ? 249 THR F O   1 
ATOM   1410 C CB  . THR A 1 214 ? 163.68804 325.01043 4.46015   1.000 50.98864  ? 249 THR F CB  1 
ATOM   1411 O OG1 . THR A 1 214 ? 163.56406 325.92323 3.37362   1.000 54.78562  ? 249 THR F OG1 1 
ATOM   1412 C CG2 . THR A 1 214 ? 163.24499 325.71875 5.73026   1.000 53.42621  ? 249 THR F CG2 1 
ATOM   1413 N N   . TYR A 1 215 ? 166.31729 324.34418 2.41714   1.000 49.06757  ? 250 TYR F N   1 
ATOM   1414 C CA  . TYR A 1 215 ? 166.89690 323.59805 1.30127   1.000 50.70836  ? 250 TYR F CA  1 
ATOM   1415 C C   . TYR A 1 215 ? 168.01848 322.67904 1.75721   1.000 57.54334  ? 250 TYR F C   1 
ATOM   1416 O O   . TYR A 1 215 ? 168.12464 321.53717 1.29005   1.000 59.28807  ? 250 TYR F O   1 
ATOM   1417 C CB  . TYR A 1 215 ? 167.41709 324.58933 0.26321   1.000 55.32905  ? 250 TYR F CB  1 
ATOM   1418 C CG  . TYR A 1 215 ? 166.29125 325.32374 -0.42816  1.000 69.14165  ? 250 TYR F CG  1 
ATOM   1419 C CD1 . TYR A 1 215 ? 165.10167 324.67082 -0.73529  1.000 70.87775  ? 250 TYR F CD1 1 
ATOM   1420 C CD2 . TYR A 1 215 ? 166.37332 326.68750 -0.68226  1.000 70.16289  ? 250 TYR F CD2 1 
ATOM   1421 C CE1 . TYR A 1 215 ? 164.05272 325.32795 -1.34864  1.000 74.45801  ? 250 TYR F CE1 1 
ATOM   1422 C CE2 . TYR A 1 215 ? 165.32137 327.36048 -1.29471  1.000 75.29326  ? 250 TYR F CE2 1 
ATOM   1423 C CZ  . TYR A 1 215 ? 164.16518 326.67586 -1.62403  1.000 77.56216  ? 250 TYR F CZ  1 
ATOM   1424 O OH  . TYR A 1 215 ? 163.11161 327.32565 -2.23115  1.000 82.00000  ? 250 TYR F OH  1 
ATOM   1425 N N   . MET A 1 216 ? 168.88818 323.16538 2.64854   1.000 53.93479  ? 251 MET F N   1 
ATOM   1426 C CA  . MET A 1 216 ? 169.93531 322.31256 3.20620   1.000 50.17746  ? 251 MET F CA  1 
ATOM   1427 C C   . MET A 1 216 ? 169.33949 321.23551 4.10039   1.000 53.44107  ? 251 MET F C   1 
ATOM   1428 O O   . MET A 1 216 ? 169.80920 320.09078 4.12329   1.000 53.34066  ? 251 MET F O   1 
ATOM   1429 C CB  . MET A 1 216 ? 170.92649 323.15794 4.01985   1.000 54.45427  ? 251 MET F CB  1 
ATOM   1430 C CG  . MET A 1 216 ? 171.68109 324.15483 3.21032   1.000 44.38230  ? 251 MET F CG  1 
ATOM   1431 S SD  . MET A 1 216 ? 172.93443 323.38306 2.25776   1.000 53.40563  ? 251 MET F SD  1 
ATOM   1432 C CE  . MET A 1 216 ? 173.47769 324.78151 1.26169   1.000 48.36637  ? 251 MET F CE  1 
ATOM   1433 N N   . LEU A 1 217 ? 168.33223 321.60107 4.88554   1.000 51.07693  ? 252 LEU F N   1 
ATOM   1434 C CA  . LEU A 1 217 ? 167.76665 320.65290 5.82678   1.000 55.59529  ? 252 LEU F CA  1 
ATOM   1435 C C   . LEU A 1 217 ? 166.32655 321.08836 6.09633   1.000 60.62511  ? 252 LEU F C   1 
ATOM   1436 O O   . LEU A 1 217 ? 166.09557 322.16093 6.67152   1.000 57.96562  ? 252 LEU F O   1 
ATOM   1437 C CB  . LEU A 1 217 ? 168.62834 320.64108 7.08406   1.000 57.28355  ? 252 LEU F CB  1 
ATOM   1438 C CG  . LEU A 1 217 ? 168.62491 319.53313 8.10050   1.000 68.58493  ? 252 LEU F CG  1 
ATOM   1439 C CD1 . LEU A 1 217 ? 169.09649 318.29910 7.34331   1.000 61.61663  ? 252 LEU F CD1 1 
ATOM   1440 C CD2 . LEU A 1 217 ? 169.58805 319.86246 9.22402   1.000 63.39903  ? 252 LEU F CD2 1 
ATOM   1441 N N   . THR A 1 218 ? 165.35618 320.27599 5.69261   1.000 61.09236  ? 253 THR F N   1 
ATOM   1442 C CA  . THR A 1 218 ? 163.96015 320.63814 5.90448   1.000 61.11586  ? 253 THR F CA  1 
ATOM   1443 C C   . THR A 1 218 ? 163.64563 320.64661 7.39440   1.000 60.46957  ? 253 THR F C   1 
ATOM   1444 O O   . THR A 1 218 ? 164.32817 320.02703 8.20744   1.000 58.13095  ? 253 THR F O   1 
ATOM   1445 C CB  . THR A 1 218 ? 163.00293 319.68271 5.17766   1.000 66.87915  ? 253 THR F CB  1 
ATOM   1446 O OG1 . THR A 1 218 ? 163.01573 318.40330 5.83262   1.000 61.82957  ? 253 THR F OG1 1 
ATOM   1447 C CG2 . THR A 1 218 ? 163.40042 319.51969 3.70493   1.000 59.29427  ? 253 THR F CG2 1 
ATOM   1448 N N   . ASN A 1 219 ? 162.61129 321.39792 7.75391   1.000 65.28940  ? 254 ASN F N   1 
ATOM   1449 C CA  . ASN A 1 219 ? 162.19217 321.40896 9.14578   1.000 67.08672  ? 254 ASN F CA  1 
ATOM   1450 C C   . ASN A 1 219 ? 161.90979 319.99796 9.62500   1.000 69.75331  ? 254 ASN F C   1 
ATOM   1451 O O   . ASN A 1 219 ? 162.23576 319.64230 10.76431  1.000 69.80200  ? 254 ASN F O   1 
ATOM   1452 C CB  . ASN A 1 219 ? 160.93844 322.25551 9.30665   1.000 66.86040  ? 254 ASN F CB  1 
ATOM   1453 C CG  . ASN A 1 219 ? 161.19112 323.72907 9.08317   1.000 76.68753  ? 254 ASN F CG  1 
ATOM   1454 O OD1 . ASN A 1 219 ? 162.22861 324.29198 9.49506   1.000 72.77402  ? 254 ASN F OD1 1 
ATOM   1455 N ND2 . ASN A 1 219 ? 160.23772 324.37427 8.41265   1.000 78.90800  ? 254 ASN F ND2 1 
ATOM   1456 N N   . SER A 1 220 ? 161.34619 319.16573 8.74913   1.000 72.15840  ? 255 SER F N   1 
ATOM   1457 C CA  . SER A 1 220 ? 161.11831 317.77100 9.10057   1.000 69.83879  ? 255 SER F CA  1 
ATOM   1458 C C   . SER A 1 220 ? 162.42589 317.02684 9.35383   1.000 68.17494  ? 255 SER F C   1 
ATOM   1459 O O   . SER A 1 220 ? 162.53709 316.26731 10.32924  1.000 66.89257  ? 255 SER F O   1 
ATOM   1460 C CB  . SER A 1 220 ? 160.33367 317.09473 7.97394   1.000 70.12288  ? 255 SER F CB  1 
ATOM   1461 O OG  . SER A 1 220 ? 160.22016 315.70558 8.19697   1.000 67.10418  ? 255 SER F OG  1 
ATOM   1462 N N   . GLU A 1 221 ? 163.43854 317.25863 8.51453   1.000 63.05514  ? 256 GLU F N   1 
ATOM   1463 C CA  . GLU A 1 221 ? 164.72611 316.59517 8.70605   1.000 66.20317  ? 256 GLU F CA  1 
ATOM   1464 C C   . GLU A 1 221 ? 165.48109 317.12828 9.91753   1.000 67.62847  ? 256 GLU F C   1 
ATOM   1465 O O   . GLU A 1 221 ? 166.17921 316.36799 10.60317  1.000 69.20360  ? 256 GLU F O   1 
ATOM   1466 C CB  . GLU A 1 221 ? 165.55679 316.73839 7.42998   1.000 64.33698  ? 256 GLU F CB  1 
ATOM   1467 C CG  . GLU A 1 221 ? 164.83830 316.25802 6.15547   1.000 65.58503  ? 256 GLU F CG  1 
ATOM   1468 C CD  . GLU A 1 221 ? 165.55869 316.67924 4.87189   1.000 71.45716  ? 256 GLU F CD  1 
ATOM   1469 O OE1 . GLU A 1 221 ? 166.47257 317.51876 4.98005   1.000 67.92870  ? 256 GLU F OE1 1 
ATOM   1470 O OE2 . GLU A 1 221 ? 165.26268 316.14058 3.77222   1.000 67.38850  ? 256 GLU F OE2 1 
ATOM   1471 N N   . LEU A 1 222 ? 165.31803 318.40949 10.22362  1.000 64.34218  ? 257 LEU F N   1 
ATOM   1472 C CA  . LEU A 1 222 ? 166.02397 318.98658 11.35271  1.000 62.39675  ? 257 LEU F CA  1 
ATOM   1473 C C   . LEU A 1 222 ? 165.49113 318.43207 12.66420  1.000 68.26123  ? 257 LEU F C   1 
ATOM   1474 O O   . LEU A 1 222 ? 166.27171 318.06718 13.55521  1.000 63.31227  ? 257 LEU F O   1 
ATOM   1475 C CB  . LEU A 1 222 ? 165.91058 320.49921 11.30474  1.000 61.34170  ? 257 LEU F CB  1 
ATOM   1476 C CG  . LEU A 1 222 ? 166.56151 321.24217 12.46323  1.000 61.71646  ? 257 LEU F CG  1 
ATOM   1477 C CD1 . LEU A 1 222 ? 168.04506 320.92055 12.53478  1.000 52.88285  ? 257 LEU F CD1 1 
ATOM   1478 C CD2 . LEU A 1 222 ? 166.30472 322.75095 12.25636  1.000 57.59213  ? 257 LEU F CD2 1 
ATOM   1479 N N   . LEU A 1 223 ? 164.16479 318.35405 12.79914  1.000 63.50800  ? 258 LEU F N   1 
ATOM   1480 C CA  . LEU A 1 223 ? 163.59404 317.80694 14.02102  1.000 66.46156  ? 258 LEU F CA  1 
ATOM   1481 C C   . LEU A 1 223 ? 163.98687 316.34946 14.19714  1.000 66.46244  ? 258 LEU F C   1 
ATOM   1482 O O   . LEU A 1 223 ? 164.23144 315.90231 15.32089  1.000 70.01419  ? 258 LEU F O   1 
ATOM   1483 C CB  . LEU A 1 223 ? 162.08415 317.95866 14.01770  1.000 63.53575  ? 258 LEU F CB  1 
ATOM   1484 C CG  . LEU A 1 223 ? 161.60194 319.38655 14.15444  1.000 68.93680  ? 258 LEU F CG  1 
ATOM   1485 C CD1 . LEU A 1 223 ? 160.09877 319.44195 14.01838  1.000 65.89247  ? 258 LEU F CD1 1 
ATOM   1486 C CD2 . LEU A 1 223 ? 162.00873 319.86596 15.54183  1.000 65.42804  ? 258 LEU F CD2 1 
ATOM   1487 N N   . SER A 1 224 ? 164.02001 315.58134 13.10287  1.000 68.01335  ? 259 SER F N   1 
ATOM   1488 C CA  . SER A 1 224 ? 164.48793 314.20255 13.19114  1.000 75.37923  ? 259 SER F CA  1 
ATOM   1489 C C   . SER A 1 224 ? 165.96511 314.14321 13.56126  1.000 76.04998  ? 259 SER F C   1 
ATOM   1490 O O   . SER A 1 224 ? 166.39119 313.22607 14.28065  1.000 78.05539  ? 259 SER F O   1 
ATOM   1491 C CB  . SER A 1 224 ? 164.22288 313.46850 11.86880  1.000 72.71072  ? 259 SER F CB  1 
ATOM   1492 O OG  . SER A 1 224 ? 165.13274 312.39607 11.68241  1.000 70.86272  ? 259 SER F OG  1 
ATOM   1493 N N   . LEU A 1 225 ? 166.75864 315.12377 13.11934  1.000 69.29413  ? 260 LEU F N   1 
ATOM   1494 C CA  . LEU A 1 225 ? 168.16555 315.11551 13.50650  1.000 70.16283  ? 260 LEU F CA  1 
ATOM   1495 C C   . LEU A 1 225 ? 168.31355 315.47491 14.96825  1.000 70.62057  ? 260 LEU F C   1 
ATOM   1496 O O   . LEU A 1 225 ? 169.16068 314.90641 15.65886  1.000 76.21272  ? 260 LEU F O   1 
ATOM   1497 C CB  . LEU A 1 225 ? 168.96982 316.07494 12.64439  1.000 69.25925  ? 260 LEU F CB  1 
ATOM   1498 C CG  . LEU A 1 225 ? 170.27939 315.43250 12.20187  1.000 76.31695  ? 260 LEU F CG  1 
ATOM   1499 C CD1 . LEU A 1 225 ? 170.01497 314.02715 11.67967  1.000 80.04143  ? 260 LEU F CD1 1 
ATOM   1500 C CD2 . LEU A 1 225 ? 170.91271 316.28295 11.10583  1.000 72.46873  ? 260 LEU F CD2 1 
ATOM   1501 N N   . ILE A 1 226 ? 167.44937 316.35416 15.47002  1.000 66.14869  ? 261 ILE F N   1 
ATOM   1502 C CA  . ILE A 1 226 ? 167.50691 316.70322 16.88370  1.000 68.46695  ? 261 ILE F CA  1 
ATOM   1503 C C   . ILE A 1 226 ? 167.17054 315.47531 17.72471  1.000 76.75809  ? 261 ILE F C   1 
ATOM   1504 O O   . ILE A 1 226 ? 167.78054 315.25005 18.78054  1.000 74.29875  ? 261 ILE F O   1 
ATOM   1505 C CB  . ILE A 1 226 ? 166.58870 317.90946 17.16849  1.000 61.17473  ? 261 ILE F CB  1 
ATOM   1506 C CG1 . ILE A 1 226 ? 167.17104 319.15923 16.47090  1.000 61.07312  ? 261 ILE F CG1 1 
ATOM   1507 C CG2 . ILE A 1 226 ? 166.41260 318.11793 18.66145  1.000 60.47064  ? 261 ILE F CG2 1 
ATOM   1508 C CD1 . ILE A 1 226 ? 166.56117 320.47339 16.88409  1.000 53.40523  ? 261 ILE F CD1 1 
ATOM   1509 N N   . ASN A 1 227 ? 166.17732 314.67884 17.29251  1.000 75.99150  ? 262 ASN F N   1 
ATOM   1510 C CA  . ASN A 1 227 ? 165.76214 313.52981 18.09273  1.000 76.32802  ? 262 ASN F CA  1 
ATOM   1511 C C   . ASN A 1 227 ? 166.86839 312.50169 18.20052  1.000 76.89739  ? 262 ASN F C   1 
ATOM   1512 O O   . ASN A 1 227 ? 166.95625 311.78844 19.20591  1.000 79.50979  ? 262 ASN F O   1 
ATOM   1513 C CB  . ASN A 1 227 ? 164.54658 312.84238 17.47193  1.000 81.30486  ? 262 ASN F CB  1 
ATOM   1514 C CG  . ASN A 1 227 ? 163.36534 312.80419 18.39822  1.000 85.93410  ? 262 ASN F CG  1 
ATOM   1515 O OD1 . ASN A 1 227 ? 163.00178 313.81644 19.00113  1.000 86.57166  ? 262 ASN F OD1 1 
ATOM   1516 N ND2 . ASN A 1 227 ? 162.76028 311.61838 18.53454  1.000 82.23494  ? 262 ASN F ND2 1 
ATOM   1517 N N   . ASP A 1 228 ? 167.74393 312.43927 17.20837  1.000 77.87886  ? 263 ASP F N   1 
ATOM   1518 C CA  . ASP A 1 228 ? 168.77081 311.41461 17.19414  1.000 79.49382  ? 263 ASP F CA  1 
ATOM   1519 C C   . ASP A 1 228 ? 170.07810 311.90916 17.80200  1.000 81.42650  ? 263 ASP F C   1 
ATOM   1520 O O   . ASP A 1 228 ? 171.11130 311.25026 17.65670  1.000 84.97981  ? 263 ASP F O   1 
ATOM   1521 C CB  . ASP A 1 228 ? 168.96653 310.91748 15.75940  1.000 79.71360  ? 263 ASP F CB  1 
ATOM   1522 C CG  . ASP A 1 228 ? 168.01472 309.76888 15.41670  1.000 85.94373  ? 263 ASP F CG  1 
ATOM   1523 O OD1 . ASP A 1 228 ? 168.36474 308.58416 15.64189  1.000 91.01914  ? 263 ASP F OD1 1 
ATOM   1524 O OD2 . ASP A 1 228 ? 166.88640 310.06245 14.95721  1.000 86.58332  ? 263 ASP F OD2 1 
ATOM   1525 N N   . MET A 1 229 ? 170.05564 313.09230 18.46800  1.000 78.57494  ? 264 MET F N   1 
ATOM   1526 C CA  . MET A 1 229 ? 171.24745 313.71478 19.02232  1.000 78.30701  ? 264 MET F CA  1 
ATOM   1527 C C   . MET A 1 229 ? 171.52415 313.14506 20.41502  1.000 76.63846  ? 264 MET F C   1 
ATOM   1528 O O   . MET A 1 229 ? 170.58754 312.86177 21.17694  1.000 68.55414  ? 264 MET F O   1 
ATOM   1529 C CB  . MET A 1 229 ? 171.07372 315.23558 19.06857  1.000 75.90795  ? 264 MET F CB  1 
ATOM   1530 C CG  . MET A 1 229 ? 171.26071 315.93674 17.70207  1.000 71.87896  ? 264 MET F CG  1 
ATOM   1531 S SD  . MET A 1 229 ? 171.19854 317.75448 17.83408  1.000 74.36409  ? 264 MET F SD  1 
ATOM   1532 C CE  . MET A 1 229 ? 172.92862 318.17131 18.03612  1.000 69.82031  ? 264 MET F CE  1 
ATOM   1533 N N   . PRO A 1 230 ? 172.80766 313.05780 20.80582  1.000 82.14505  ? 265 PRO F N   1 
ATOM   1534 C CA  . PRO A 1 230 ? 173.19304 312.59638 22.15344  1.000 69.73034  ? 265 PRO F CA  1 
ATOM   1535 C C   . PRO A 1 230 ? 173.00752 313.67162 23.21103  1.000 72.30505  ? 265 PRO F C   1 
ATOM   1536 O O   . PRO A 1 230 ? 173.96504 314.08455 23.89477  1.000 76.29638  ? 265 PRO F O   1 
ATOM   1537 C CB  . PRO A 1 230 ? 174.67133 312.22547 21.96862  1.000 75.34680  ? 265 PRO F CB  1 
ATOM   1538 C CG  . PRO A 1 230 ? 175.14506 313.18242 20.90465  1.000 74.06415  ? 265 PRO F CG  1 
ATOM   1539 C CD  . PRO A 1 230 ? 173.97460 313.34406 19.96020  1.000 77.32860  ? 265 PRO F CD  1 
ATOM   1540 N N   . ILE A 1 231 ? 171.76508 314.12540 23.35564  1.000 64.38257  ? 266 ILE F N   1 
ATOM   1541 C CA  . ILE A 1 231 ? 171.42423 315.13288 24.34357  1.000 71.55825  ? 266 ILE F CA  1 
ATOM   1542 C C   . ILE A 1 231 ? 170.24425 314.67038 25.18056  1.000 69.99952  ? 266 ILE F C   1 
ATOM   1543 O O   . ILE A 1 231 ? 169.49864 313.76242 24.81483  1.000 64.39023  ? 266 ILE F O   1 
ATOM   1544 C CB  . ILE A 1 231 ? 171.09761 316.48510 23.68710  1.000 72.86778  ? 266 ILE F CB  1 
ATOM   1545 C CG1 . ILE A 1 231 ? 170.03483 316.28322 22.60421  1.000 74.25430  ? 266 ILE F CG1 1 
ATOM   1546 C CG2 . ILE A 1 231 ? 172.32497 317.10868 23.07086  1.000 71.26499  ? 266 ILE F CG2 1 
ATOM   1547 C CD1 . ILE A 1 231 ? 169.51109 317.53945 21.92521  1.000 72.46973  ? 266 ILE F CD1 1 
ATOM   1548 N N   . THR A 1 232 ? 170.04158 315.37527 26.28761  1.000 69.27282  ? 267 THR F N   1 
ATOM   1549 C CA  . THR A 1 232 ? 168.97597 315.00184 27.19452  1.000 74.93873  ? 267 THR F CA  1 
ATOM   1550 C C   . THR A 1 232 ? 167.65180 315.26658 26.49780  1.000 76.68252  ? 267 THR F C   1 
ATOM   1551 O O   . THR A 1 232 ? 167.58169 315.95708 25.47703  1.000 76.38684  ? 267 THR F O   1 
ATOM   1552 C CB  . THR A 1 232 ? 169.03436 315.78663 28.50510  1.000 76.02905  ? 267 THR F CB  1 
ATOM   1553 O OG1 . THR A 1 232 ? 168.59590 317.12968 28.27239  1.000 77.80176  ? 267 THR F OG1 1 
ATOM   1554 C CG2 . THR A 1 232 ? 170.45066 315.79214 29.06589  1.000 70.34268  ? 267 THR F CG2 1 
ATOM   1555 N N   . ASN A 1 233 ? 166.59651 314.66790 27.02250  1.000 75.90565  ? 268 ASN F N   1 
ATOM   1556 C CA  . ASN A 1 233 ? 165.30139 314.94029 26.43321  1.000 78.28842  ? 268 ASN F CA  1 
ATOM   1557 C C   . ASN A 1 233 ? 164.90850 316.39596 26.63761  1.000 77.00151  ? 268 ASN F C   1 
ATOM   1558 O O   . ASN A 1 233 ? 164.18597 316.95624 25.80541  1.000 75.38759  ? 268 ASN F O   1 
ATOM   1559 C CB  . ASN A 1 233 ? 164.24142 313.98249 26.97019  1.000 80.01556  ? 268 ASN F CB  1 
ATOM   1560 C CG  . ASN A 1 233 ? 164.20341 312.67785 26.18789  1.000 85.32328  ? 268 ASN F CG  1 
ATOM   1561 O OD1 . ASN A 1 233 ? 163.41485 312.52178 25.25230  1.000 83.80049  ? 268 ASN F OD1 1 
ATOM   1562 N ND2 . ASN A 1 233 ? 165.02307 311.71532 26.60340  1.000 89.16768  ? 268 ASN F ND2 1 
ATOM   1563 N N   . ASP A 1 234 ? 165.35790 317.02707 27.72704  1.000 79.75523  ? 269 ASP F N   1 
ATOM   1564 C CA  . ASP A 1 234 ? 165.06883 318.44836 27.86394  1.000 76.41247  ? 269 ASP F CA  1 
ATOM   1565 C C   . ASP A 1 234 ? 165.80780 319.31747 26.84011  1.000 80.52678  ? 269 ASP F C   1 
ATOM   1566 O O   . ASP A 1 234 ? 165.27302 320.35776 26.43492  1.000 75.50550  ? 269 ASP F O   1 
ATOM   1567 C CB  . ASP A 1 234 ? 165.35304 318.92018 29.28758  1.000 87.66842  ? 269 ASP F CB  1 
ATOM   1568 C CG  . ASP A 1 234 ? 164.30967 319.90833 29.77311  1.000 98.71789  ? 269 ASP F CG  1 
ATOM   1569 O OD1 . ASP A 1 234 ? 163.13725 319.71275 29.37523  1.000 94.67229  ? 269 ASP F OD1 1 
ATOM   1570 O OD2 . ASP A 1 234 ? 164.63776 320.83465 30.55408  1.000 105.17233 ? 269 ASP F OD2 1 
ATOM   1571 N N   . GLN A 1 235 ? 166.94801 318.87780 26.30594  1.000 77.40444  ? 270 GLN F N   1 
ATOM   1572 C CA  . GLN A 1 235 ? 167.59411 319.73041 25.32121  1.000 72.11214  ? 270 GLN F CA  1 
ATOM   1573 C C   . GLN A 1 235 ? 166.95701 319.52253 23.95978  1.000 72.77412  ? 270 GLN F C   1 
ATOM   1574 O O   . GLN A 1 235 ? 166.89122 320.46749 23.16182  1.000 71.67181  ? 270 GLN F O   1 
ATOM   1575 C CB  . GLN A 1 235 ? 169.10609 319.51196 25.18245  1.000 72.40131  ? 270 GLN F CB  1 
ATOM   1576 C CG  . GLN A 1 235 ? 169.98594 319.63457 26.42769  1.000 76.07198  ? 270 GLN F CG  1 
ATOM   1577 C CD  . GLN A 1 235 ? 171.43171 319.16039 26.15273  1.000 81.09990  ? 270 GLN F CD  1 
ATOM   1578 O OE1 . GLN A 1 235 ? 172.25737 319.89285 25.57290  1.000 70.70381  ? 270 GLN F OE1 1 
ATOM   1579 N NE2 . GLN A 1 235 ? 171.71817 317.90165 26.51596  1.000 78.55061  ? 270 GLN F NE2 1 
ATOM   1580 N N   . LYS A 1 236 ? 166.42990 318.32490 23.69372  1.000 73.58261  ? 271 LYS F N   1 
ATOM   1581 C CA  . LYS A 1 236 ? 165.74504 318.12273 22.42844  1.000 66.76688  ? 271 LYS F CA  1 
ATOM   1582 C C   . LYS A 1 236 ? 164.46974 318.94753 22.39719  1.000 67.96398  ? 271 LYS F C   1 
ATOM   1583 O O   . LYS A 1 236 ? 164.13190 319.55578 21.37206  1.000 67.11740  ? 271 LYS F O   1 
ATOM   1584 C CB  . LYS A 1 236 ? 165.40081 316.64013 22.26644  1.000 66.20916  ? 271 LYS F CB  1 
ATOM   1585 C CG  . LYS A 1 236 ? 166.59011 315.70862 22.17220  1.000 71.98184  ? 271 LYS F CG  1 
ATOM   1586 C CD  . LYS A 1 236 ? 166.13265 314.26791 22.05132  1.000 71.73497  ? 271 LYS F CD  1 
ATOM   1587 C CE  . LYS A 1 236 ? 167.30103 313.30648 21.99049  1.000 72.47828  ? 271 LYS F CE  1 
ATOM   1588 N NZ  . LYS A 1 236 ? 166.82793 311.89939 21.89033  1.000 71.67432  ? 271 LYS F NZ  1 
ATOM   1589 N N   . LYS A 1 237 ? 163.77590 319.03855 23.52475  1.000 67.71084  ? 272 LYS F N   1 
ATOM   1590 C CA  . LYS A 1 237 ? 162.60567 319.89611 23.53540  1.000 70.71085  ? 272 LYS F CA  1 
ATOM   1591 C C   . LYS A 1 237 ? 162.98347 321.35701 23.34427  1.000 71.40412  ? 272 LYS F C   1 
ATOM   1592 O O   . LYS A 1 237 ? 162.24619 322.09899 22.68359  1.000 68.21506  ? 272 LYS F O   1 
ATOM   1593 C CB  . LYS A 1 237 ? 161.82554 319.68724 24.83270  1.000 80.14283  ? 272 LYS F CB  1 
ATOM   1594 C CG  . LYS A 1 237 ? 160.33093 319.96369 24.72465  1.000 77.66725  ? 272 LYS F CG  1 
ATOM   1595 C CD  . LYS A 1 237 ? 159.68759 319.80676 26.09449  1.000 88.34411  ? 272 LYS F CD  1 
ATOM   1596 C CE  . LYS A 1 237 ? 159.99139 320.98672 27.00880  1.000 94.29513  ? 272 LYS F CE  1 
ATOM   1597 N NZ  . LYS A 1 237 ? 159.83349 320.60894 28.44741  1.000 98.55023  ? 272 LYS F NZ  1 
ATOM   1598 N N   . LEU A 1 238 ? 164.16861 321.75899 23.81888  1.000 70.73557  ? 273 LEU F N   1 
ATOM   1599 C CA  . LEU A 1 238 ? 164.58496 323.15442 23.68976  1.000 66.60498  ? 273 LEU F CA  1 
ATOM   1600 C C   . LEU A 1 238 ? 164.93126 323.50600 22.25374  1.000 62.13601  ? 273 LEU F C   1 
ATOM   1601 O O   . LEU A 1 238 ? 164.44862 324.51032 21.72138  1.000 56.57377  ? 273 LEU F O   1 
ATOM   1602 C CB  . LEU A 1 238 ? 165.78798 323.43737 24.58831  1.000 71.59943  ? 273 LEU F CB  1 
ATOM   1603 C CG  . LEU A 1 238 ? 166.25337 324.89576 24.63408  1.000 65.15433  ? 273 LEU F CG  1 
ATOM   1604 C CD1 . LEU A 1 238 ? 165.19238 325.83895 25.19518  1.000 58.08805  ? 273 LEU F CD1 1 
ATOM   1605 C CD2 . LEU A 1 238 ? 167.55593 325.00222 25.41423  1.000 58.91396  ? 273 LEU F CD2 1 
ATOM   1606 N N   . MET A 1 239 ? 165.74989 322.67756 21.60553  1.000 61.09057  ? 274 MET F N   1 
ATOM   1607 C CA  . MET A 1 239 ? 166.13744 322.96679 20.23861  1.000 55.14250  ? 274 MET F CA  1 
ATOM   1608 C C   . MET A 1 239 ? 164.95053 322.80821 19.29750  1.000 60.70751  ? 274 MET F C   1 
ATOM   1609 O O   . MET A 1 239 ? 164.81562 323.55788 18.31401  1.000 55.87813  ? 274 MET F O   1 
ATOM   1610 C CB  . MET A 1 239 ? 167.26164 322.02366 19.83686  1.000 56.12569  ? 274 MET F CB  1 
ATOM   1611 C CG  . MET A 1 239 ? 168.46294 322.11234 20.74644  1.000 53.56863  ? 274 MET F CG  1 
ATOM   1612 S SD  . MET A 1 239 ? 169.75964 320.97687 20.23044  1.000 62.60397  ? 274 MET F SD  1 
ATOM   1613 C CE  . MET A 1 239 ? 170.22648 321.56456 18.59306  1.000 54.94170  ? 274 MET F CE  1 
ATOM   1614 N N   . SER A 1 240 ? 164.02149 321.91018 19.63218  1.000 62.74781  ? 275 SER F N   1 
ATOM   1615 C CA  . SER A 1 240 ? 162.86602 321.70085 18.76075  1.000 65.25188  ? 275 SER F CA  1 
ATOM   1616 C C   . SER A 1 240 ? 161.88302 322.85277 18.86776  1.000 62.96203  ? 275 SER F C   1 
ATOM   1617 O O   . SER A 1 240 ? 161.21547 323.19205 17.88590  1.000 62.28257  ? 275 SER F O   1 
ATOM   1618 C CB  . SER A 1 240 ? 162.18536 320.37715 19.10072  1.000 62.33431  ? 275 SER F CB  1 
ATOM   1619 O OG  . SER A 1 240 ? 163.08648 319.30056 18.91771  1.000 63.79163  ? 275 SER F OG  1 
ATOM   1620 N N   . ASN A 1 241 ? 161.85015 323.52621 20.01255  1.000 59.58076  ? 276 ASN F N   1 
ATOM   1621 C CA  . ASN A 1 241 ? 160.98302 324.67920 20.17863  1.000 56.82997  ? 276 ASN F CA  1 
ATOM   1622 C C   . ASN A 1 241 ? 161.61637 325.97105 19.68296  1.000 59.47375  ? 276 ASN F C   1 
ATOM   1623 O O   . ASN A 1 241 ? 160.94388 327.00254 19.70133  1.000 60.73967  ? 276 ASN F O   1 
ATOM   1624 C CB  . ASN A 1 241 ? 160.58580 324.82663 21.65234  1.000 66.28856  ? 276 ASN F CB  1 
ATOM   1625 C CG  . ASN A 1 241 ? 159.70237 323.67412 22.15084  1.000 78.08029  ? 276 ASN F CG  1 
ATOM   1626 O OD1 . ASN A 1 241 ? 159.66897 322.58806 21.56074  1.000 77.86826  ? 276 ASN F OD1 1 
ATOM   1627 N ND2 . ASN A 1 241 ? 159.03846 323.89131 23.28222  1.000 81.07897  ? 276 ASN F ND2 1 
ATOM   1628 N N   . ASN A 1 242 ? 162.90962 325.96538 19.34270  1.000 55.47460  ? 277 ASN F N   1 
ATOM   1629 C CA  . ASN A 1 242 ? 163.61821 327.13368 18.81494  1.000 50.24207  ? 277 ASN F CA  1 
ATOM   1630 C C   . ASN A 1 242 ? 164.42320 326.75076 17.57751  1.000 53.07230  ? 277 ASN F C   1 
ATOM   1631 O O   . ASN A 1 242 ? 165.59687 327.12584 17.43306  1.000 46.25207  ? 277 ASN F O   1 
ATOM   1632 C CB  . ASN A 1 242 ? 164.53716 327.71990 19.86872  1.000 50.40882  ? 277 ASN F CB  1 
ATOM   1633 C CG  . ASN A 1 242 ? 163.81310 328.06408 21.12180  1.000 53.30706  ? 277 ASN F CG  1 
ATOM   1634 O OD1 . ASN A 1 242 ? 163.25485 329.15425 21.25637  1.000 56.80630  ? 277 ASN F OD1 1 
ATOM   1635 N ND2 . ASN A 1 242 ? 163.83761 327.14596 22.07695  1.000 53.28816  ? 277 ASN F ND2 1 
ATOM   1636 N N   . VAL A 1 243 ? 163.75661 326.13873 16.58702  1.000 48.56278  ? 278 VAL F N   1 
ATOM   1637 C CA  . VAL A 1 243 ? 164.48725 325.65190 15.42192  1.000 42.10681  ? 278 VAL F CA  1 
ATOM   1638 C C   . VAL A 1 243 ? 165.07716 326.77948 14.60921  1.000 45.73536  ? 278 VAL F C   1 
ATOM   1639 O O   . VAL A 1 243 ? 166.10460 326.59066 13.94252  1.000 49.55641  ? 278 VAL F O   1 
ATOM   1640 C CB  . VAL A 1 243 ? 163.57447 324.77129 14.54398  1.000 54.38302  ? 278 VAL F CB  1 
ATOM   1641 C CG1 . VAL A 1 243 ? 163.19200 323.50625 15.27461  1.000 58.11276  ? 278 VAL F CG1 1 
ATOM   1642 C CG2 . VAL A 1 243 ? 162.29731 325.52423 14.17635  1.000 43.49584  ? 278 VAL F CG2 1 
ATOM   1643 N N   . GLN A 1 244 ? 164.42514 327.93693 14.56495  1.000 45.01552  ? 279 GLN F N   1 
ATOM   1644 C CA  . GLN A 1 244 ? 165.00001 329.02009 13.77931  1.000 43.48361  ? 279 GLN F CA  1 
ATOM   1645 C C   . GLN A 1 244 ? 166.26686 329.56167 14.42596  1.000 44.20281  ? 279 GLN F C   1 
ATOM   1646 O O   . GLN A 1 244 ? 167.24302 329.87433 13.73768  1.000 46.06303  ? 279 GLN F O   1 
ATOM   1647 C CB  . GLN A 1 244 ? 163.95952 330.11771 13.57283  1.000 48.77685  ? 279 GLN F CB  1 
ATOM   1648 C CG  . GLN A 1 244 ? 162.81844 329.59473 12.71100  1.000 60.30631  ? 279 GLN F CG  1 
ATOM   1649 C CD  . GLN A 1 244 ? 163.30890 329.10241 11.34593  1.000 63.98310  ? 279 GLN F CD  1 
ATOM   1650 O OE1 . GLN A 1 244 ? 164.25785 329.65624 10.76035  1.000 62.32829  ? 279 GLN F OE1 1 
ATOM   1651 N NE2 . GLN A 1 244 ? 162.69644 328.02114 10.86248  1.000 62.26826  ? 279 GLN F NE2 1 
ATOM   1652 N N   . ILE A 1 245 ? 166.29064 329.65250 15.75158  1.000 41.24738  ? 280 ILE F N   1 
ATOM   1653 C CA  . ILE A 1 245 ? 167.52383 330.06882 16.40205  1.000 45.27303  ? 280 ILE F CA  1 
ATOM   1654 C C   . ILE A 1 245 ? 168.59253 329.00609 16.21948  1.000 45.58902  ? 280 ILE F C   1 
ATOM   1655 O O   . ILE A 1 245 ? 169.74745 329.31711 15.89380  1.000 42.74312  ? 280 ILE F O   1 
ATOM   1656 C CB  . ILE A 1 245 ? 167.24584 330.35021 17.89031  1.000 47.75146  ? 280 ILE F CB  1 
ATOM   1657 C CG1 . ILE A 1 245 ? 166.33718 331.57239 18.04348  1.000 50.63941  ? 280 ILE F CG1 1 
ATOM   1658 C CG2 . ILE A 1 245 ? 168.52169 330.44427 18.66027  1.000 41.98081  ? 280 ILE F CG2 1 
ATOM   1659 C CD1 . ILE A 1 245 ? 166.06489 331.94537 19.46992  1.000 51.44671  ? 280 ILE F CD1 1 
ATOM   1660 N N   . VAL A 1 246 ? 168.18876 327.73384 16.26498  1.000 44.91626  ? 281 VAL F N   1 
ATOM   1661 C CA  . VAL A 1 246 ? 169.13774 326.65077 16.03659  1.000 42.70274  ? 281 VAL F CA  1 
ATOM   1662 C C   . VAL A 1 246 ? 169.69887 326.74975 14.63674  1.000 42.29690  ? 281 VAL F C   1 
ATOM   1663 O O   . VAL A 1 246 ? 170.88356 326.46968 14.40525  1.000 43.30973  ? 281 VAL F O   1 
ATOM   1664 C CB  . VAL A 1 246 ? 168.48890 325.28134 16.28663  1.000 43.70220  ? 281 VAL F CB  1 
ATOM   1665 C CG1 . VAL A 1 246 ? 169.44596 324.18674 15.81307  1.000 42.30116  ? 281 VAL F CG1 1 
ATOM   1666 C CG2 . VAL A 1 246 ? 168.07979 325.13063 17.75963  1.000 40.78822  ? 281 VAL F CG2 1 
ATOM   1667 N N   . ARG A 1 247 ? 168.84095 327.06524 13.66061  1.000 42.04184  ? 282 ARG F N   1 
ATOM   1668 C CA  . ARG A 1 247 ? 169.31801 327.24111 12.28827  1.000 37.91878  ? 282 ARG F CA  1 
ATOM   1669 C C   . ARG A 1 247 ? 170.31078 328.39118 12.18647  1.000 42.92765  ? 282 ARG F C   1 
ATOM   1670 O O   . ARG A 1 247 ? 171.27889 328.32966 11.41702  1.000 44.94668  ? 282 ARG F O   1 
ATOM   1671 C CB  . ARG A 1 247 ? 168.14133 327.48188 11.34099  1.000 49.05024  ? 282 ARG F CB  1 
ATOM   1672 C CG  . ARG A 1 247 ? 167.21302 326.27988 11.14488  1.000 53.91127  ? 282 ARG F CG  1 
ATOM   1673 C CD  . ARG A 1 247 ? 166.10424 326.61717 10.13747  1.000 56.14524  ? 282 ARG F CD  1 
ATOM   1674 N NE  . ARG A 1 247 ? 165.26572 325.45828 9.85495   1.000 52.20799  ? 282 ARG F NE  1 
ATOM   1675 C CZ  . ARG A 1 247 ? 165.58276 324.57135 8.92266   1.000 52.43147  ? 282 ARG F CZ  1 
ATOM   1676 N NH1 . ARG A 1 247 ? 166.68612 324.70042 8.19423   1.000 47.89060  ? 282 ARG F NH1 1 
ATOM   1677 N NH2 . ARG A 1 247 ? 164.78580 323.52994 8.71539   1.000 58.18562  ? 282 ARG F NH2 1 
ATOM   1678 N N   . GLN A 1 248 ? 170.02322 329.49576 12.86135  1.000 43.97824  ? 283 GLN F N   1 
ATOM   1679 C CA  . GLN A 1 248 ? 170.91276 330.65161 12.82021  1.000 46.20834  ? 283 GLN F CA  1 
ATOM   1680 C C   . GLN A 1 248 ? 172.22951 330.39546 13.52566  1.000 47.97501  ? 283 GLN F C   1 
ATOM   1681 O O   . GLN A 1 248 ? 173.18213 331.13954 13.30599  1.000 46.52054  ? 283 GLN F O   1 
ATOM   1682 C CB  . GLN A 1 248 ? 170.20350 331.86752 13.39075  1.000 44.69365  ? 283 GLN F CB  1 
ATOM   1683 C CG  . GLN A 1 248 ? 169.04235 332.22844 12.47441  1.000 40.94035  ? 283 GLN F CG  1 
ATOM   1684 C CD  . GLN A 1 248 ? 168.16347 333.30829 13.02075  1.000 58.51623  ? 283 GLN F CD  1 
ATOM   1685 O OE1 . GLN A 1 248 ? 168.29679 333.73403 14.18147  1.000 57.82032  ? 283 GLN F OE1 1 
ATOM   1686 N NE2 . GLN A 1 248 ? 167.22027 333.74908 12.19375  1.000 63.90708  ? 283 GLN F NE2 1 
ATOM   1687 N N   . GLN A 1 249 ? 172.30913 329.37846 14.38486  1.000 46.50850  ? 284 GLN F N   1 
ATOM   1688 C CA  . GLN A 1 249 ? 173.56656 329.06395 15.04298  1.000 44.64388  ? 284 GLN F CA  1 
ATOM   1689 C C   . GLN A 1 249 ? 174.15744 327.75569 14.52288  1.000 47.77568  ? 284 GLN F C   1 
ATOM   1690 O O   . GLN A 1 249 ? 174.92978 327.09541 15.22006  1.000 51.13610  ? 284 GLN F O   1 
ATOM   1691 C CB  . GLN A 1 249 ? 173.33366 329.02603 16.56038  1.000 38.14226  ? 284 GLN F CB  1 
ATOM   1692 C CG  . GLN A 1 249 ? 172.98664 330.44162 17.08317  1.000 44.17204  ? 284 GLN F CG  1 
ATOM   1693 C CD  . GLN A 1 249 ? 172.85416 330.55912 18.59659  1.000 51.65861  ? 284 GLN F CD  1 
ATOM   1694 O OE1 . GLN A 1 249 ? 172.74357 329.56761 19.31256  1.000 52.32564  ? 284 GLN F OE1 1 
ATOM   1695 N NE2 . GLN A 1 249 ? 172.89974 331.79401 19.09116  1.000 53.21305  ? 284 GLN F NE2 1 
ATOM   1696 N N   . SER A 1 250 ? 173.85466 327.40625 13.26688  1.000 45.68225  ? 285 SER F N   1 
ATOM   1697 C CA  . SER A 1 250 ? 174.36082 326.19499 12.62645  1.000 39.52558  ? 285 SER F CA  1 
ATOM   1698 C C   . SER A 1 250 ? 175.09432 326.53443 11.33845  1.000 42.19371  ? 285 SER F C   1 
ATOM   1699 O O   . SER A 1 250 ? 174.95537 327.62102 10.77882  1.000 43.05253  ? 285 SER F O   1 
ATOM   1700 C CB  . SER A 1 250 ? 173.23454 325.19837 12.32987  1.000 40.02566  ? 285 SER F CB  1 
ATOM   1701 O OG  . SER A 1 250 ? 172.60304 324.77924 13.52687  1.000 46.35790  ? 285 SER F OG  1 
ATOM   1702 N N   . TYR A 1 251 ? 175.85485 325.56083 10.84584  1.000 42.62675  ? 286 TYR F N   1 
ATOM   1703 C CA  . TYR A 1 251 ? 176.60017 325.69590 9.60165   1.000 41.46996  ? 286 TYR F CA  1 
ATOM   1704 C C   . TYR A 1 251 ? 176.32104 324.49354 8.70912   1.000 50.26768  ? 286 TYR F C   1 
ATOM   1705 O O   . TYR A 1 251 ? 176.08213 323.37231 9.18426   1.000 43.71071  ? 286 TYR F O   1 
ATOM   1706 C CB  . TYR A 1 251 ? 178.11522 325.77521 9.83981   1.000 43.60336  ? 286 TYR F CB  1 
ATOM   1707 C CG  . TYR A 1 251 ? 178.64792 327.07260 10.38535  1.000 49.04032  ? 286 TYR F CG  1 
ATOM   1708 C CD1 . TYR A 1 251 ? 178.97346 328.12908 9.54546   1.000 47.09212  ? 286 TYR F CD1 1 
ATOM   1709 C CD2 . TYR A 1 251 ? 178.81072 327.24791 11.77110  1.000 48.87236  ? 286 TYR F CD2 1 
ATOM   1710 C CE1 . TYR A 1 251 ? 179.46258 329.32010 10.05453  1.000 51.97416  ? 286 TYR F CE1 1 
ATOM   1711 C CE2 . TYR A 1 251 ? 179.29040 328.44834 12.28338  1.000 53.56519  ? 286 TYR F CE2 1 
ATOM   1712 C CZ  . TYR A 1 251 ? 179.61410 329.47518 11.41849  1.000 45.41701  ? 286 TYR F CZ  1 
ATOM   1713 O OH  . TYR A 1 251 ? 180.09711 330.65725 11.92883  1.000 58.43987  ? 286 TYR F OH  1 
ATOM   1714 N N   . SER A 1 252 ? 176.31352 324.75203 7.41114   1.000 48.76687  ? 287 SER F N   1 
ATOM   1715 C CA  . SER A 1 252 ? 176.22198 323.71729 6.39387   1.000 50.30750  ? 287 SER F CA  1 
ATOM   1716 C C   . SER A 1 252 ? 177.48289 323.81399 5.55545   1.000 49.52424  ? 287 SER F C   1 
ATOM   1717 O O   . SER A 1 252 ? 177.78969 324.89157 5.02191   1.000 47.16031  ? 287 SER F O   1 
ATOM   1718 C CB  . SER A 1 252 ? 174.96022 323.88007 5.54614   1.000 55.93650  ? 287 SER F CB  1 
ATOM   1719 O OG  . SER A 1 252 ? 174.85851 322.81795 4.62659   1.000 49.57584  ? 287 SER F OG  1 
ATOM   1720 N N   . ILE A 1 253 ? 178.27678 322.74537 5.55936   1.000 43.44663  ? 288 ILE F N   1 
ATOM   1721 C CA  . ILE A 1 253 ? 179.58736 322.71684 4.91195   1.000 52.99717  ? 288 ILE F CA  1 
ATOM   1722 C C   . ILE A 1 253 ? 179.59339 321.69456 3.78180   1.000 59.85325  ? 288 ILE F C   1 
ATOM   1723 O O   . ILE A 1 253 ? 179.27830 320.51257 3.99394   1.000 55.63829  ? 288 ILE F O   1 
ATOM   1724 C CB  . ILE A 1 253 ? 180.73941 322.45855 5.90204   1.000 57.39436  ? 288 ILE F CB  1 
ATOM   1725 C CG1 . ILE A 1 253 ? 180.62492 323.39626 7.11503   1.000 50.42727  ? 288 ILE F CG1 1 
ATOM   1726 C CG2 . ILE A 1 253 ? 182.07589 322.57980 5.19483   1.000 53.06086  ? 288 ILE F CG2 1 
ATOM   1727 C CD1 . ILE A 1 253 ? 180.79352 322.68006 8.43266   1.000 59.15854  ? 288 ILE F CD1 1 
ATOM   1728 N N   . MET A 1 254 ? 180.05491 322.13051 2.61489   1.000 53.94695  ? 289 MET F N   1 
ATOM   1729 C CA  . MET A 1 254 ? 180.11438 321.26332 1.45877   1.000 57.11797  ? 289 MET F CA  1 
ATOM   1730 C C   . MET A 1 254 ? 181.35347 320.37677 1.52174   1.000 64.62608  ? 289 MET F C   1 
ATOM   1731 O O   . MET A 1 254 ? 182.47598 320.87159 1.62032   1.000 67.10383  ? 289 MET F O   1 
ATOM   1732 C CB  . MET A 1 254 ? 180.19272 322.15713 0.21891   1.000 58.01043  ? 289 MET F CB  1 
ATOM   1733 C CG  . MET A 1 254 ? 179.12626 321.93458 -0.80303  1.000 71.97557  ? 289 MET F CG  1 
ATOM   1734 S SD  . MET A 1 254 ? 179.26689 320.36317 -1.63828  1.000 75.87957  ? 289 MET F SD  1 
ATOM   1735 C CE  . MET A 1 254 ? 180.65035 320.68387 -2.74905  1.000 75.23971  ? 289 MET F CE  1 
ATOM   1736 N N   . CYS A 1 255 ? 181.14377 319.06805 1.35591   1.000 63.02487  ? 290 CYS F N   1 
ATOM   1737 C CA  . CYS A 1 255 ? 182.17759 318.03379 1.39522   1.000 67.03726  ? 290 CYS F CA  1 
ATOM   1738 C C   . CYS A 1 255 ? 182.60117 317.77769 -0.04447  1.000 78.62022  ? 290 CYS F C   1 
ATOM   1739 O O   . CYS A 1 255 ? 183.45435 318.50021 -0.56294  1.000 83.45639  ? 290 CYS F O   1 
ATOM   1740 C CB  . CYS A 1 255 ? 181.69424 316.77558 2.10782   1.000 69.78202  ? 290 CYS F CB  1 
ATOM   1741 S SG  . CYS A 1 255 ? 181.61356 316.92644 3.95384   1.000 81.52180  ? 290 CYS F SG  1 
ATOM   1742 N N   . ILE A 1 256 ? 182.13418 316.70154 -0.66945  1.000 71.21222  ? 291 ILE F N   1 
ATOM   1743 C CA  . ILE A 1 256 ? 182.63109 316.35271 -1.99370  1.000 77.89017  ? 291 ILE F CA  1 
ATOM   1744 C C   . ILE A 1 256 ? 181.52818 315.84432 -2.91027  1.000 74.25319  ? 291 ILE F C   1 
ATOM   1745 O O   . ILE A 1 256 ? 180.43809 315.47547 -2.45987  1.000 69.03889  ? 291 ILE F O   1 
ATOM   1746 C CB  . ILE A 1 256 ? 183.76172 315.30994 -1.90469  1.000 79.12005  ? 291 ILE F CB  1 
ATOM   1747 C CG1 . ILE A 1 256 ? 184.46381 315.22223 -3.27384  1.000 82.42748  ? 291 ILE F CG1 1 
ATOM   1748 C CG2 . ILE A 1 256 ? 183.19712 313.98760 -1.36368  1.000 68.51599  ? 291 ILE F CG2 1 
ATOM   1749 C CD1 . ILE A 1 256 ? 185.13102 316.52603 -3.76286  1.000 78.15914  ? 291 ILE F CD1 1 
ATOM   1750 N N   . ILE A 1 257 ? 181.75272 315.99684 -4.21809  1.000 80.88059  ? 292 ILE F N   1 
ATOM   1751 C CA  . ILE A 1 257 ? 180.91351 315.33730 -5.21373  1.000 81.00255  ? 292 ILE F CA  1 
ATOM   1752 C C   . ILE A 1 257 ? 181.78854 314.28104 -5.87834  1.000 84.41679  ? 292 ILE F C   1 
ATOM   1753 O O   . ILE A 1 257 ? 182.69765 314.62806 -6.64708  1.000 81.35776  ? 292 ILE F O   1 
ATOM   1754 C CB  . ILE A 1 257 ? 180.42788 316.32394 -6.27517  1.000 77.90633  ? 292 ILE F CB  1 
ATOM   1755 C CG1 . ILE A 1 257 ? 179.49407 317.36609 -5.68589  1.000 85.45709  ? 292 ILE F CG1 1 
ATOM   1756 C CG2 . ILE A 1 257 ? 179.68629 315.56544 -7.34473  1.000 77.34502  ? 292 ILE F CG2 1 
ATOM   1757 C CD1 . ILE A 1 257 ? 178.08457 316.86732 -5.52452  1.000 84.36515  ? 292 ILE F CD1 1 
ATOM   1758 N N   . LYS A 1 258 ? 181.49673 313.00047 -5.65111  1.000 86.11915  ? 293 LYS F N   1 
ATOM   1759 C CA  . LYS A 1 258 ? 182.37302 311.97175 -6.19935  1.000 85.04397  ? 293 LYS F CA  1 
ATOM   1760 C C   . LYS A 1 258 ? 181.60794 310.65639 -6.26154  1.000 93.09451  ? 293 LYS F C   1 
ATOM   1761 O O   . LYS A 1 258 ? 180.94834 310.29125 -5.27539  1.000 88.39492  ? 293 LYS F O   1 
ATOM   1762 C CB  . LYS A 1 258 ? 183.69567 311.74701 -5.44609  1.000 83.84705  ? 293 LYS F CB  1 
ATOM   1763 C CG  . LYS A 1 258 ? 183.69787 310.55385 -4.48808  1.000 89.75593  ? 293 LYS F CG  1 
ATOM   1764 C CD  . LYS A 1 258 ? 185.08840 310.32720 -3.89249  1.000 91.97196  ? 293 LYS F CD  1 
ATOM   1765 C CE  . LYS A 1 258 ? 185.12951 309.12221 -2.94917  1.000 98.39393  ? 293 LYS F CE  1 
ATOM   1766 N NZ  . LYS A 1 258 ? 186.28022 308.20226 -3.18803  1.000 99.43380  ? 293 LYS F NZ  1 
ATOM   1767 N N   . GLU A 1 259 ? 181.65239 309.96991 -7.40343  1.000 95.89881  ? 294 GLU F N   1 
ATOM   1768 C CA  . GLU A 1 259 ? 181.06555 308.63603 -7.51481  1.000 90.78833  ? 294 GLU F CA  1 
ATOM   1769 C C   . GLU A 1 259 ? 179.58579 308.63691 -7.15022  1.000 87.15005  ? 294 GLU F C   1 
ATOM   1770 O O   . GLU A 1 259 ? 179.12077 307.86831 -6.30009  1.000 85.53210  ? 294 GLU F O   1 
ATOM   1771 C CB  . GLU A 1 259 ? 181.82232 307.73564 -6.54113  1.000 90.39606  ? 294 GLU F CB  1 
ATOM   1772 C CG  . GLU A 1 259 ? 183.29869 307.57717 -6.84643  1.000 92.98627  ? 294 GLU F CG  1 
ATOM   1773 C CD  . GLU A 1 259 ? 184.01013 306.73717 -5.80207  1.000 99.08386  ? 294 GLU F CD  1 
ATOM   1774 O OE1 . GLU A 1 259 ? 183.34283 306.30138 -4.83304  1.000 100.52199 ? 294 GLU F OE1 1 
ATOM   1775 O OE2 . GLU A 1 259 ? 185.25323 306.60177 -5.89613  1.000 98.81366  ? 294 GLU F OE2 1 
ATOM   1776 N N   . GLU A 1 260 ? 178.85468 309.50130 -7.85520  1.000 88.19380  ? 295 GLU F N   1 
ATOM   1777 C CA  . GLU A 1 260 ? 177.39265 309.59212 -7.79806  1.000 90.71045  ? 295 GLU F CA  1 
ATOM   1778 C C   . GLU A 1 260 ? 176.88855 309.92051 -6.39552  1.000 84.12342  ? 295 GLU F C   1 
ATOM   1779 O O   . GLU A 1 260 ? 175.78579 309.51440 -6.00942  1.000 80.43356  ? 295 GLU F O   1 
ATOM   1780 C CB  . GLU A 1 260 ? 176.77816 308.26966 -8.25129  1.000 90.92116  ? 295 GLU F CB  1 
ATOM   1781 C CG  . GLU A 1 260 ? 177.45051 307.68050 -9.46965  1.000 94.82312  ? 295 GLU F CG  1 
ATOM   1782 C CD  . GLU A 1 260 ? 176.82885 306.36674 -9.86760  1.000 103.22960 ? 295 GLU F CD  1 
ATOM   1783 O OE1 . GLU A 1 260 ? 176.83580 305.42516 -9.03358  1.000 102.04725 ? 295 GLU F OE1 1 
ATOM   1784 O OE2 . GLU A 1 260 ? 176.29137 306.30673 -11.00453 1.000 104.96422 ? 295 GLU F OE2 1 
ATOM   1785 N N   . VAL A 1 261 ? 177.66189 310.67894 -5.62396  1.000 86.70100  ? 296 VAL F N   1 
ATOM   1786 C CA  . VAL A 1 261 ? 177.26831 311.04713 -4.26700  1.000 79.81332  ? 296 VAL F CA  1 
ATOM   1787 C C   . VAL A 1 261 ? 177.63119 312.49851 -4.01436  1.000 72.51455  ? 296 VAL F C   1 
ATOM   1788 O O   . VAL A 1 261 ? 178.73799 312.93382 -4.34449  1.000 73.72993  ? 296 VAL F O   1 
ATOM   1789 C CB  . VAL A 1 261 ? 177.87612 310.14144 -3.18194  1.000 83.19534  ? 296 VAL F CB  1 
ATOM   1790 C CG1 . VAL A 1 261 ? 177.68914 310.80572 -1.81415  1.000 82.08763  ? 296 VAL F CG1 1 
ATOM   1791 C CG2 . VAL A 1 261 ? 177.21604 308.74729 -3.22365  1.000 82.89880  ? 296 VAL F CG2 1 
ATOM   1792 N N   . LEU A 1 262 ? 176.66370 313.26599 -3.54836  1.000 75.14979  ? 297 LEU F N   1 
ATOM   1793 C CA  . LEU A 1 262 ? 176.86824 314.62776 -3.07347  1.000 70.08983  ? 297 LEU F CA  1 
ATOM   1794 C C   . LEU A 1 262 ? 176.72776 314.61561 -1.56257  1.000 66.07558  ? 297 LEU F C   1 
ATOM   1795 O O   . LEU A 1 262 ? 175.68591 314.19645 -1.04544  1.000 64.38478  ? 297 LEU F O   1 
ATOM   1796 C CB  . LEU A 1 262 ? 175.87516 315.61202 -3.67664  1.000 72.35831  ? 297 LEU F CB  1 
ATOM   1797 C CG  . LEU A 1 262 ? 175.80375 316.88132 -2.82837  1.000 66.57467  ? 297 LEU F CG  1 
ATOM   1798 C CD1 . LEU A 1 262 ? 177.12839 317.60193 -2.79401  1.000 70.94119  ? 297 LEU F CD1 1 
ATOM   1799 C CD2 . LEU A 1 262 ? 174.74720 317.75537 -3.44151  1.000 68.37279  ? 297 LEU F CD2 1 
ATOM   1800 N N   . ALA A 1 263 ? 177.79953 314.95305 -0.85462  1.000 65.67349  ? 298 ALA F N   1 
ATOM   1801 C CA  . ALA A 1 263 ? 177.78445 314.90407 0.60197   1.000 66.12250  ? 298 ALA F CA  1 
ATOM   1802 C C   . ALA A 1 263 ? 178.15134 316.28393 1.13205   1.000 60.47595  ? 298 ALA F C   1 
ATOM   1803 O O   . ALA A 1 263 ? 179.04010 316.96094 0.60010   1.000 60.10714  ? 298 ALA F O   1 
ATOM   1804 C CB  . ALA A 1 263 ? 178.73577 313.83738 1.16167   1.000 62.81768  ? 298 ALA F CB  1 
ATOM   1805 N N   . TYR A 1 264 ? 177.47767 316.67498 2.20466   1.000 60.08710  ? 299 TYR F N   1 
ATOM   1806 C CA  . TYR A 1 264 ? 177.77809 317.91155 2.89645   1.000 51.58206  ? 299 TYR F CA  1 
ATOM   1807 C C   . TYR A 1 264 ? 177.42786 317.71926 4.36168   1.000 60.44174  ? 299 TYR F C   1 
ATOM   1808 O O   . TYR A 1 264 ? 176.57631 316.88830 4.70361   1.000 54.77386  ? 299 TYR F O   1 
ATOM   1809 C CB  . TYR A 1 264 ? 177.02279 319.11578 2.29361   1.000 50.48247  ? 299 TYR F CB  1 
ATOM   1810 C CG  . TYR A 1 264 ? 175.49005 319.08633 2.29465   1.000 55.35811  ? 299 TYR F CG  1 
ATOM   1811 C CD1 . TYR A 1 264 ? 174.75507 319.39444 3.44625   1.000 59.49215  ? 299 TYR F CD1 1 
ATOM   1812 C CD2 . TYR A 1 264 ? 174.77158 318.76850 1.13819   1.000 55.54213  ? 299 TYR F CD2 1 
ATOM   1813 C CE1 . TYR A 1 264 ? 173.34592 319.39089 3.44138   1.000 51.61732  ? 299 TYR F CE1 1 
ATOM   1814 C CE2 . TYR A 1 264 ? 173.35098 318.75757 1.12737   1.000 52.30009  ? 299 TYR F CE2 1 
ATOM   1815 C CZ  . TYR A 1 264 ? 172.65743 319.05826 2.27651   1.000 53.38934  ? 299 TYR F CZ  1 
ATOM   1816 O OH  . TYR A 1 264 ? 171.27819 319.05533 2.25673   1.000 50.04555  ? 299 TYR F OH  1 
ATOM   1817 N N   . VAL A 1 265 ? 178.18832 318.41401 5.22795   1.000 57.53366  ? 300 VAL F N   1 
ATOM   1818 C CA  . VAL A 1 265 ? 178.09856 318.28170 6.68129   1.000 53.76054  ? 300 VAL F CA  1 
ATOM   1819 C C   . VAL A 1 265 ? 177.28337 319.44324 7.24956   1.000 56.80411  ? 300 VAL F C   1 
ATOM   1820 O O   . VAL A 1 265 ? 177.49547 320.60936 6.88548   1.000 50.49615  ? 300 VAL F O   1 
ATOM   1821 C CB  . VAL A 1 265 ? 179.49784 318.21540 7.31753   1.000 59.07705  ? 300 VAL F CB  1 
ATOM   1822 C CG1 . VAL A 1 265 ? 179.40957 318.29070 8.81781   1.000 65.19234  ? 300 VAL F CG1 1 
ATOM   1823 C CG2 . VAL A 1 265 ? 180.13181 316.87916 6.98045   1.000 64.95012  ? 300 VAL F CG2 1 
ATOM   1824 N N   . VAL A 1 266 ? 176.32832 319.12914 8.11897   1.000 51.31007  ? 301 VAL F N   1 
ATOM   1825 C CA  . VAL A 1 266 ? 175.61954 320.14376 8.88051   1.000 49.74559  ? 301 VAL F CA  1 
ATOM   1826 C C   . VAL A 1 266 ? 176.16064 320.13382 10.29858  1.000 56.07516  ? 301 VAL F C   1 
ATOM   1827 O O   . VAL A 1 266 ? 176.25053 319.06997 10.92842  1.000 54.18804  ? 301 VAL F O   1 
ATOM   1828 C CB  . VAL A 1 266 ? 174.09969 319.95021 8.86022   1.000 50.55340  ? 301 VAL F CB  1 
ATOM   1829 C CG1 . VAL A 1 266 ? 173.55472 320.18635 7.45435   1.000 56.20278  ? 301 VAL F CG1 1 
ATOM   1830 C CG2 . VAL A 1 266 ? 173.71586 318.57717 9.39198   1.000 62.28614  ? 301 VAL F CG2 1 
ATOM   1831 N N   . GLN A 1 267 ? 176.62085 321.30417 10.75222  1.000 51.57678  ? 302 GLN F N   1 
ATOM   1832 C CA  . GLN A 1 267 ? 177.24531 321.46159 12.05632  1.000 47.55827  ? 302 GLN F CA  1 
ATOM   1833 C C   . GLN A 1 267 ? 176.22414 322.14038 12.97144  1.000 44.21183  ? 302 GLN F C   1 
ATOM   1834 O O   . GLN A 1 267 ? 175.91473 323.31678 12.78244  1.000 47.11780  ? 302 GLN F O   1 
ATOM   1835 C CB  . GLN A 1 267 ? 178.51253 322.28468 11.87531  1.000 47.55647  ? 302 GLN F CB  1 
ATOM   1836 C CG  . GLN A 1 267 ? 179.46999 322.27681 12.98760  1.000 52.68945  ? 302 GLN F CG  1 
ATOM   1837 C CD  . GLN A 1 267 ? 180.71008 323.00776 12.58469  1.000 50.47320  ? 302 GLN F CD  1 
ATOM   1838 O OE1 . GLN A 1 267 ? 181.57104 322.47337 11.88676  1.000 54.70594  ? 302 GLN F OE1 1 
ATOM   1839 N NE2 . GLN A 1 267 ? 180.81949 324.25243 13.03372  1.000 56.99457  ? 302 GLN F NE2 1 
ATOM   1840 N N   . LEU A 1 268 ? 175.63968 321.39052 13.92085  1.000 50.27316  ? 303 LEU F N   1 
ATOM   1841 C CA  . LEU A 1 268 ? 174.55990 321.87610 14.78442  1.000 45.62704  ? 303 LEU F CA  1 
ATOM   1842 C C   . LEU A 1 268 ? 175.06732 322.23368 16.18230  1.000 53.17254  ? 303 LEU F C   1 
ATOM   1843 O O   . LEU A 1 268 ? 175.98035 321.58179 16.70652  1.000 47.67860  ? 303 LEU F O   1 
ATOM   1844 C CB  . LEU A 1 268 ? 173.45343 320.83224 14.94081  1.000 51.74811  ? 303 LEU F CB  1 
ATOM   1845 C CG  . LEU A 1 268 ? 172.66740 320.28630 13.74899  1.000 56.28741  ? 303 LEU F CG  1 
ATOM   1846 C CD1 . LEU A 1 268 ? 171.26373 319.93586 14.21986  1.000 56.05076  ? 303 LEU F CD1 1 
ATOM   1847 C CD2 . LEU A 1 268 ? 172.59876 321.29306 12.64385  1.000 51.08044  ? 303 LEU F CD2 1 
ATOM   1848 N N   . PRO A 1 269 ? 174.46371 323.21498 16.86135  1.000 49.38110  ? 304 PRO F N   1 
ATOM   1849 C CA  . PRO A 1 269 ? 175.01160 323.64317 18.15079  1.000 47.13695  ? 304 PRO F CA  1 
ATOM   1850 C C   . PRO A 1 269 ? 174.70784 322.65858 19.26930  1.000 51.67463  ? 304 PRO F C   1 
ATOM   1851 O O   . PRO A 1 269 ? 173.61624 322.08398 19.34895  1.000 49.87838  ? 304 PRO F O   1 
ATOM   1852 C CB  . PRO A 1 269 ? 174.28636 324.97309 18.41529  1.000 46.87247  ? 304 PRO F CB  1 
ATOM   1853 C CG  . PRO A 1 269 ? 172.98634 324.83611 17.72102  1.000 40.42209  ? 304 PRO F CG  1 
ATOM   1854 C CD  . PRO A 1 269 ? 173.29439 324.02930 16.47331  1.000 43.97341  ? 304 PRO F CD  1 
ATOM   1855 N N   . LEU A 1 270 ? 175.67983 322.50745 20.17209  1.000 48.56062  ? 305 LEU F N   1 
ATOM   1856 C CA  . LEU A 1 270 ? 175.49012 321.76267 21.40743  1.000 47.57276  ? 305 LEU F CA  1 
ATOM   1857 C C   . LEU A 1 270 ? 175.58733 322.79626 22.51881  1.000 47.05623  ? 305 LEU F C   1 
ATOM   1858 O O   . LEU A 1 270 ? 176.62540 323.44521 22.68915  1.000 45.60987  ? 305 LEU F O   1 
ATOM   1859 C CB  . LEU A 1 270 ? 176.53921 320.64897 21.56916  1.000 50.53614  ? 305 LEU F CB  1 
ATOM   1860 C CG  . LEU A 1 270 ? 176.44127 319.35706 20.73929  1.000 54.21402  ? 305 LEU F CG  1 
ATOM   1861 C CD1 . LEU A 1 270 ? 177.54547 318.37960 21.09401  1.000 50.86138  ? 305 LEU F CD1 1 
ATOM   1862 C CD2 . LEU A 1 270 ? 175.09869 318.69590 21.05469  1.000 56.10583  ? 305 LEU F CD2 1 
ATOM   1863 N N   . TYR A 1 271 ? 174.52111 322.92954 23.28440  1.000 44.19462  ? 306 TYR F N   1 
ATOM   1864 C CA  . TYR A 1 271 ? 174.45699 323.93815 24.33290  1.000 48.25498  ? 306 TYR F CA  1 
ATOM   1865 C C   . TYR A 1 271 ? 174.84719 323.23838 25.62926  1.000 49.32440  ? 306 TYR F C   1 
ATOM   1866 O O   . TYR A 1 271 ? 173.99983 322.68532 26.33854  1.000 53.97912  ? 306 TYR F O   1 
ATOM   1867 C CB  . TYR A 1 271 ? 173.06450 324.58256 24.39440  1.000 46.58459  ? 306 TYR F CB  1 
ATOM   1868 C CG  . TYR A 1 271 ? 172.66253 325.29845 23.09485  1.000 49.87810  ? 306 TYR F CG  1 
ATOM   1869 C CD1 . TYR A 1 271 ? 173.12569 326.59567 22.79839  1.000 47.31591  ? 306 TYR F CD1 1 
ATOM   1870 C CD2 . TYR A 1 271 ? 171.78293 324.69158 22.18440  1.000 46.57063  ? 306 TYR F CD2 1 
ATOM   1871 C CE1 . TYR A 1 271 ? 172.75896 327.24973 21.60129  1.000 45.22012  ? 306 TYR F CE1 1 
ATOM   1872 C CE2 . TYR A 1 271 ? 171.41198 325.32298 21.01509  1.000 46.58977  ? 306 TYR F CE2 1 
ATOM   1873 C CZ  . TYR A 1 271 ? 171.89606 326.59461 20.72731  1.000 46.74012  ? 306 TYR F CZ  1 
ATOM   1874 O OH  . TYR A 1 271 ? 171.51556 327.18992 19.56724  1.000 44.98720  ? 306 TYR F OH  1 
ATOM   1875 N N   . GLY A 1 272 ? 176.14811 323.27908 25.94567  1.000 54.64440  ? 307 GLY F N   1 
ATOM   1876 C CA  . GLY A 1 272 ? 176.64678 322.70319 27.19206  1.000 55.20648  ? 307 GLY F CA  1 
ATOM   1877 C C   . GLY A 1 272 ? 176.21658 323.48287 28.41001  1.000 57.64333  ? 307 GLY F C   1 
ATOM   1878 O O   . GLY A 1 272 ? 176.10857 322.91586 29.51491  1.000 49.76626  ? 307 GLY F O   1 
ATOM   1879 N N   . VAL A 1 273 ? 175.84279 324.73830 28.20114  1.000 52.87139  ? 308 VAL F N   1 
ATOM   1880 C CA  . VAL A 1 273 ? 175.36821 325.61299 29.25006  1.000 50.11343  ? 308 VAL F CA  1 
ATOM   1881 C C   . VAL A 1 273 ? 173.88736 325.80843 29.03081  1.000 46.90562  ? 308 VAL F C   1 
ATOM   1882 O O   . VAL A 1 273 ? 173.46288 326.28480 27.97256  1.000 50.28214  ? 308 VAL F O   1 
ATOM   1883 C CB  . VAL A 1 273 ? 176.08049 326.97167 29.22804  1.000 47.19313  ? 308 VAL F CB  1 
ATOM   1884 C CG1 . VAL A 1 273 ? 175.85315 327.67215 30.54614  1.000 46.22784  ? 308 VAL F CG1 1 
ATOM   1885 C CG2 . VAL A 1 273 ? 177.56010 326.80891 28.92651  1.000 45.19277  ? 308 VAL F CG2 1 
ATOM   1886 N N   . ILE A 1 274 ? 173.09518 325.39182 29.98819  1.000 44.92466  ? 309 ILE F N   1 
ATOM   1887 C CA  . ILE A 1 274 ? 171.65421 325.51950 29.86315  1.000 51.31358  ? 309 ILE F CA  1 
ATOM   1888 C C   . ILE A 1 274 ? 171.11716 326.18724 31.10547  1.000 53.15920  ? 309 ILE F C   1 
ATOM   1889 O O   . ILE A 1 274 ? 171.57817 325.92151 32.22063  1.000 53.38774  ? 309 ILE F O   1 
ATOM   1890 C CB  . ILE A 1 274 ? 170.97139 324.15174 29.65849  1.000 58.79621  ? 309 ILE F CB  1 
ATOM   1891 C CG1 . ILE A 1 274 ? 171.52396 323.48915 28.40062  1.000 65.53857  ? 309 ILE F CG1 1 
ATOM   1892 C CG2 . ILE A 1 274 ? 169.45730 324.27652 29.66502  1.000 63.77094  ? 309 ILE F CG2 1 
ATOM   1893 C CD1 . ILE A 1 274 ? 170.92144 324.11485 27.15753  1.000 56.11106  ? 309 ILE F CD1 1 
ATOM   1894 N N   . ASP A 1 275 ? 170.18586 327.10117 30.91204  1.000 48.34166  ? 310 ASP F N   1 
ATOM   1895 C CA  . ASP A 1 275 ? 169.56062 327.75592 32.04928  1.000 49.18096  ? 310 ASP F CA  1 
ATOM   1896 C C   . ASP A 1 275 ? 170.59412 328.46864 32.92707  1.000 42.90471  ? 310 ASP F C   1 
ATOM   1897 O O   . ASP A 1 275 ? 170.38510 328.64630 34.12789  1.000 50.79087  ? 310 ASP F O   1 
ATOM   1898 C CB  . ASP A 1 275 ? 168.77773 326.69630 32.83811  1.000 53.38561  ? 310 ASP F CB  1 
ATOM   1899 C CG  . ASP A 1 275 ? 167.44305 326.32040 32.14172  1.000 59.51007  ? 310 ASP F CG  1 
ATOM   1900 O OD1 . ASP A 1 275 ? 167.44250 326.29969 30.89249  1.000 63.38128  ? 310 ASP F OD1 1 
ATOM   1901 O OD2 . ASP A 1 275 ? 166.43448 325.95992 32.80023  1.000 65.30990  ? 310 ASP F OD2 1 
ATOM   1902 N N   . THR A 1 276 ? 171.64060 329.08712 32.28817  1.000 42.81025  ? 311 THR F N   1 
ATOM   1903 C CA  . THR A 1 276 ? 172.55865 329.79938 33.17312  1.000 42.78238  ? 311 THR F CA  1 
ATOM   1904 C C   . THR A 1 276 ? 172.05430 331.22762 33.34740  1.000 42.89252  ? 311 THR F C   1 
ATOM   1905 O O   . THR A 1 276 ? 171.36920 331.76011 32.46420  1.000 45.36974  ? 311 THR F O   1 
ATOM   1906 C CB  . THR A 1 276 ? 173.97902 329.81464 32.61756  1.000 44.05053  ? 311 THR F CB  1 
ATOM   1907 O OG1 . THR A 1 276 ? 174.80283 330.56877 33.50835  1.000 49.07850  ? 311 THR F OG1 1 
ATOM   1908 C CG2 . THR A 1 276 ? 174.03118 330.50958 31.25205  1.000 40.39770  ? 311 THR F CG2 1 
ATOM   1909 N N   . PRO A 1 277 ? 172.23706 331.83453 34.51754  1.000 45.33644  ? 312 PRO F N   1 
ATOM   1910 C CA  . PRO A 1 277 ? 171.74701 333.21072 34.69276  1.000 49.85826  ? 312 PRO F CA  1 
ATOM   1911 C C   . PRO A 1 277 ? 172.42395 334.14236 33.69948  1.000 44.73035  ? 312 PRO F C   1 
ATOM   1912 O O   . PRO A 1 277 ? 173.65651 334.17164 33.58667  1.000 44.87386  ? 312 PRO F O   1 
ATOM   1913 C CB  . PRO A 1 277 ? 172.16173 333.55605 36.13014  1.000 48.27830  ? 312 PRO F CB  1 
ATOM   1914 C CG  . PRO A 1 277 ? 172.32115 332.18721 36.83134  1.000 47.15591  ? 312 PRO F CG  1 
ATOM   1915 C CD  . PRO A 1 277 ? 172.84653 331.27603 35.74273  1.000 44.49162  ? 312 PRO F CD  1 
ATOM   1916 N N   . CYS A 1 278 ? 171.61273 334.98547 33.06933  1.000 38.05894  ? 313 CYS F N   1 
ATOM   1917 C CA  . CYS A 1 278 ? 172.09836 335.93940 32.08758  1.000 43.79505  ? 313 CYS F CA  1 
ATOM   1918 C C   . CYS A 1 278 ? 171.40749 337.25813 32.35976  1.000 43.12713  ? 313 CYS F C   1 
ATOM   1919 O O   . CYS A 1 278 ? 170.26838 337.28368 32.83792  1.000 41.12292  ? 313 CYS F O   1 
ATOM   1920 C CB  . CYS A 1 278 ? 171.75554 335.53967 30.64744  1.000 38.84243  ? 313 CYS F CB  1 
ATOM   1921 S SG  . CYS A 1 278 ? 172.64362 334.13949 29.99202  1.000 43.74458  ? 313 CYS F SG  1 
ATOM   1922 N N   . TRP A 1 279 ? 172.08316 338.34661 32.00688  1.000 38.34666  ? 314 TRP F N   1 
ATOM   1923 C CA  . TRP A 1 279 ? 171.50915 339.67331 32.16282  1.000 42.91545  ? 314 TRP F CA  1 
ATOM   1924 C C   . TRP A 1 279 ? 172.06902 340.57212 31.06642  1.000 41.31443  ? 314 TRP F C   1 
ATOM   1925 O O   . TRP A 1 279 ? 173.09095 340.27273 30.44069  1.000 38.92026  ? 314 TRP F O   1 
ATOM   1926 C CB  . TRP A 1 279 ? 171.78506 340.26692 33.57260  1.000 37.00995  ? 314 TRP F CB  1 
ATOM   1927 C CG  . TRP A 1 279 ? 173.25058 340.43924 33.92223  1.000 37.81525  ? 314 TRP F CG  1 
ATOM   1928 C CD1 . TRP A 1 279 ? 173.97292 341.60103 33.88611  1.000 39.01075  ? 314 TRP F CD1 1 
ATOM   1929 C CD2 . TRP A 1 279 ? 174.16687 339.41562 34.34851  1.000 40.36600  ? 314 TRP F CD2 1 
ATOM   1930 N NE1 . TRP A 1 279 ? 175.28826 341.36296 34.26123  1.000 43.39876  ? 314 TRP F NE1 1 
ATOM   1931 C CE2 . TRP A 1 279 ? 175.42822 340.02855 34.54047  1.000 44.39117  ? 314 TRP F CE2 1 
ATOM   1932 C CE3 . TRP A 1 279 ? 174.04297 338.04342 34.59081  1.000 42.34789  ? 314 TRP F CE3 1 
ATOM   1933 C CZ2 . TRP A 1 279 ? 176.55111 339.31332 34.95884  1.000 43.87898  ? 314 TRP F CZ2 1 
ATOM   1934 C CZ3 . TRP A 1 279 ? 175.16097 337.34352 34.98380  1.000 43.82870  ? 314 TRP F CZ3 1 
ATOM   1935 C CH2 . TRP A 1 279 ? 176.39151 337.97977 35.17705  1.000 39.77499  ? 314 TRP F CH2 1 
ATOM   1936 N N   . LYS A 1 280 ? 171.39391 341.69785 30.86331  1.000 37.67025  ? 315 LYS F N   1 
ATOM   1937 C CA  . LYS A 1 280 ? 171.72253 342.64565 29.81701  1.000 38.63513  ? 315 LYS F CA  1 
ATOM   1938 C C   . LYS A 1 280 ? 171.92663 344.02730 30.42515  1.000 37.87928  ? 315 LYS F C   1 
ATOM   1939 O O   . LYS A 1 280 ? 171.05891 344.51198 31.15564  1.000 36.41322  ? 315 LYS F O   1 
ATOM   1940 C CB  . LYS A 1 280 ? 170.61300 342.71316 28.76571  1.000 40.14840  ? 315 LYS F CB  1 
ATOM   1941 C CG  . LYS A 1 280 ? 171.05590 343.54458 27.58846  1.000 43.23265  ? 315 LYS F CG  1 
ATOM   1942 C CD  . LYS A 1 280 ? 170.13763 343.46020 26.39280  1.000 41.44476  ? 315 LYS F CD  1 
ATOM   1943 C CE  . LYS A 1 280 ? 170.81240 344.18440 25.24873  1.000 43.65959  ? 315 LYS F CE  1 
ATOM   1944 N NZ  . LYS A 1 280 ? 170.00451 344.08709 24.01698  1.000 57.77607  ? 315 LYS F NZ  1 
ATOM   1945 N N   . LEU A 1 281 ? 173.09868 344.60641 30.19874  1.000 31.82398  ? 316 LEU F N   1 
ATOM   1946 C CA  . LEU A 1 281 ? 173.44635 345.93272 30.69328  1.000 33.59341  ? 316 LEU F CA  1 
ATOM   1947 C C   . LEU A 1 281 ? 173.10642 346.98778 29.63584  1.000 37.40605  ? 316 LEU F C   1 
ATOM   1948 O O   . LEU A 1 281 ? 173.52837 346.85729 28.47691  1.000 34.79519  ? 316 LEU F O   1 
ATOM   1949 C CB  . LEU A 1 281 ? 174.93207 345.97704 31.03590  1.000 33.61491  ? 316 LEU F CB  1 
ATOM   1950 C CG  . LEU A 1 281 ? 175.50097 347.33792 31.38818  1.000 35.80403  ? 316 LEU F CG  1 
ATOM   1951 C CD1 . LEU A 1 281 ? 174.83561 347.90290 32.65469  1.000 35.93827  ? 316 LEU F CD1 1 
ATOM   1952 C CD2 . LEU A 1 281 ? 177.02213 347.19861 31.54499  1.000 33.04793  ? 316 LEU F CD2 1 
ATOM   1953 N N   . HIS A 1 282 ? 172.39189 348.04714 30.04478  1.000 36.14493  ? 317 HIS F N   1 
ATOM   1954 C CA  . HIS A 1 282 ? 172.04755 349.18588 29.18807  1.000 31.59569  ? 317 HIS F CA  1 
ATOM   1955 C C   . HIS A 1 282 ? 172.72358 350.43486 29.75834  1.000 33.89789  ? 317 HIS F C   1 
ATOM   1956 O O   . HIS A 1 282 ? 172.71240 350.64325 30.97913  1.000 36.71970  ? 317 HIS F O   1 
ATOM   1957 C CB  . HIS A 1 282 ? 170.53552 349.43420 29.23867  1.000 31.49922  ? 317 HIS F CB  1 
ATOM   1958 C CG  . HIS A 1 282 ? 169.73021 348.22083 28.94531  1.000 35.26793  ? 317 HIS F CG  1 
ATOM   1959 N ND1 . HIS A 1 282 ? 169.31154 347.86583 27.67837  1.000 41.86830  ? 317 HIS F ND1 1 
ATOM   1960 C CD2 . HIS A 1 282 ? 169.23478 347.28010 29.78770  1.000 32.24078  ? 317 HIS F CD2 1 
ATOM   1961 C CE1 . HIS A 1 282 ? 168.62472 346.73518 27.74846  1.000 36.08167  ? 317 HIS F CE1 1 
ATOM   1962 N NE2 . HIS A 1 282 ? 168.55137 346.36795 29.01849  1.000 36.59484  ? 317 HIS F NE2 1 
ATOM   1963 N N   . THR A 1 283 ? 173.37985 351.22939 28.92220  1.000 36.06394  ? 318 THR F N   1 
ATOM   1964 C CA  . THR A 1 283 ? 174.07572 352.41426 29.43082  1.000 33.43594  ? 318 THR F CA  1 
ATOM   1965 C C   . THR A 1 283 ? 173.64961 353.64794 28.63225  1.000 40.66535  ? 318 THR F C   1 
ATOM   1966 O O   . THR A 1 283 ? 173.29333 353.53821 27.45352  1.000 35.93515  ? 318 THR F O   1 
ATOM   1967 C CB  . THR A 1 283 ? 175.59078 352.25491 29.36196  1.000 36.14246  ? 318 THR F CB  1 
ATOM   1968 O OG1 . THR A 1 283 ? 175.97040 352.17281 27.98724  1.000 38.17018  ? 318 THR F OG1 1 
ATOM   1969 C CG2 . THR A 1 283 ? 176.02730 350.95104 30.06642  1.000 32.80133  ? 318 THR F CG2 1 
ATOM   1970 N N   . SER A 1 284 ? 173.72382 354.83221 29.25376  1.000 35.93095  ? 319 SER F N   1 
ATOM   1971 C CA  . SER A 1 284 ? 173.33251 356.06341 28.58860  1.000 33.83665  ? 319 SER F CA  1 
ATOM   1972 C C   . SER A 1 284 ? 174.18393 357.19422 29.17075  1.000 37.28312  ? 319 SER F C   1 
ATOM   1973 O O   . SER A 1 284 ? 174.64011 357.07759 30.31470  1.000 37.76560  ? 319 SER F O   1 
ATOM   1974 C CB  . SER A 1 284 ? 171.83053 356.29787 28.76163  1.000 37.44495  ? 319 SER F CB  1 
ATOM   1975 O OG  . SER A 1 284 ? 171.34831 357.31842 27.89686  1.000 41.60718  ? 319 SER F OG  1 
ATOM   1976 N N   . PRO A 1 285 ? 174.48079 358.25061 28.39881  1.000 32.04729  ? 320 PRO F N   1 
ATOM   1977 C CA  . PRO A 1 285 ? 175.37806 359.31301 28.89956  1.000 40.77934  ? 320 PRO F CA  1 
ATOM   1978 C C   . PRO A 1 285 ? 174.83561 360.03680 30.13043  1.000 40.42428  ? 320 PRO F C   1 
ATOM   1979 O O   . PRO A 1 285 ? 173.69414 360.50475 30.13152  1.000 35.78550  ? 320 PRO F O   1 
ATOM   1980 C CB  . PRO A 1 285 ? 175.46711 360.28069 27.72167  1.000 36.82693  ? 320 PRO F CB  1 
ATOM   1981 C CG  . PRO A 1 285 ? 175.15111 359.46458 26.52679  1.000 47.06160  ? 320 PRO F CG  1 
ATOM   1982 C CD  . PRO A 1 285 ? 174.11849 358.46219 26.98877  1.000 39.59231  ? 320 PRO F CD  1 
ATOM   1983 N N   . LEU A 1 286 ? 175.73242 360.28880 31.09378  1.000 36.46261  ? 321 LEU F N   1 
ATOM   1984 C CA  . LEU A 1 286 ? 175.45607 360.97874 32.36136  1.000 39.82452  ? 321 LEU F CA  1 
ATOM   1985 C C   . LEU A 1 286 ? 176.28685 362.26053 32.38710  1.000 44.19589  ? 321 LEU F C   1 
ATOM   1986 O O   . LEU A 1 286 ? 177.50753 362.20564 32.55141  1.000 44.53241  ? 321 LEU F O   1 
ATOM   1987 C CB  . LEU A 1 286 ? 175.82190 360.11628 33.55210  1.000 36.27635  ? 321 LEU F CB  1 
ATOM   1988 C CG  . LEU A 1 286 ? 175.57339 360.65546 34.94367  1.000 43.29930  ? 321 LEU F CG  1 
ATOM   1989 C CD1 . LEU A 1 286 ? 174.07481 360.75100 35.24474  1.000 44.37098  ? 321 LEU F CD1 1 
ATOM   1990 C CD2 . LEU A 1 286 ? 176.29980 359.81324 35.96505  1.000 40.80492  ? 321 LEU F CD2 1 
ATOM   1991 N N   . CYS A 1 287 ? 175.65502 363.39253 32.10285  1.000 44.11709  ? 322 CYS F N   1 
ATOM   1992 C CA  . CYS A 1 287 ? 176.31801 364.68945 32.03899  1.000 45.28998  ? 322 CYS F CA  1 
ATOM   1993 C C   . CYS A 1 287 ? 175.86121 365.60949 33.16695  1.000 46.58620  ? 322 CYS F C   1 
ATOM   1994 O O   . CYS A 1 287 ? 174.80170 365.41132 33.76598  1.000 45.85686  ? 322 CYS F O   1 
ATOM   1995 C CB  . CYS A 1 287 ? 176.02120 365.35578 30.69389  1.000 35.81580  ? 322 CYS F CB  1 
ATOM   1996 S SG  . CYS A 1 287 ? 176.42116 364.32163 29.24043  1.000 42.63585  ? 322 CYS F SG  1 
ATOM   1997 N N   . THR A 1 288 ? 176.60924 366.70113 33.36884  1.000 47.46975  ? 323 THR F N   1 
ATOM   1998 C CA  . THR A 1 288 ? 176.13091 367.70806 34.30359  1.000 49.00130  ? 323 THR F CA  1 
ATOM   1999 C C   . THR A 1 288 ? 175.19114 368.62328 33.52744  1.000 52.41732  ? 323 THR F C   1 
ATOM   2000 O O   . THR A 1 288 ? 175.24472 368.69201 32.29230  1.000 46.74339  ? 323 THR F O   1 
ATOM   2001 C CB  . THR A 1 288 ? 177.28599 368.55599 34.88925  1.000 47.36845  ? 323 THR F CB  1 
ATOM   2002 O OG1 . THR A 1 288 ? 178.06514 369.12436 33.82331  1.000 48.99133  ? 323 THR F OG1 1 
ATOM   2003 C CG2 . THR A 1 288 ? 178.20074 367.74710 35.79342  1.000 43.59740  ? 323 THR F CG2 1 
ATOM   2004 N N   . THR A 1 289 ? 174.33476 369.33351 34.26983  1.000 53.16417  ? 324 THR F N   1 
ATOM   2005 C CA  . THR A 1 289 ? 173.26446 370.14701 33.69099  1.000 61.15968  ? 324 THR F CA  1 
ATOM   2006 C C   . THR A 1 289 ? 173.41384 371.63709 33.99431  1.000 65.85082  ? 324 THR F C   1 
ATOM   2007 O O   . THR A 1 289 ? 172.42912 372.30260 34.33071  1.000 70.53442  ? 324 THR F O   1 
ATOM   2008 C CB  . THR A 1 289 ? 171.91745 369.62038 34.15026  1.000 49.57473  ? 324 THR F CB  1 
ATOM   2009 O OG1 . THR A 1 289 ? 171.86857 369.64141 35.58328  1.000 55.19549  ? 324 THR F OG1 1 
ATOM   2010 C CG2 . THR A 1 289 ? 171.74328 368.18926 33.62358  1.000 47.62059  ? 324 THR F CG2 1 
ATOM   2011 N N   . ASN A 1 290 ? 174.59620 372.19292 33.79430  1.000 68.29970  ? 325 ASN F N   1 
ATOM   2012 C CA  . ASN A 1 290 ? 174.74283 373.62882 33.94324  1.000 76.49454  ? 325 ASN F CA  1 
ATOM   2013 C C   . ASN A 1 290 ? 174.09450 374.38098 32.79697  1.000 83.94617  ? 325 ASN F C   1 
ATOM   2014 O O   . ASN A 1 290 ? 173.93521 373.87004 31.68065  1.000 75.91167  ? 325 ASN F O   1 
ATOM   2015 C CB  . ASN A 1 290 ? 176.21877 374.01688 34.01603  1.000 78.04425  ? 325 ASN F CB  1 
ATOM   2016 C CG  . ASN A 1 290 ? 176.75445 374.00840 35.42574  1.000 86.49062  ? 325 ASN F CG  1 
ATOM   2017 O OD1 . ASN A 1 290 ? 176.57494 373.03962 36.18587  1.000 78.53421  ? 325 ASN F OD1 1 
ATOM   2018 N ND2 . ASN A 1 290 ? 177.44093 375.09395 35.78727  1.000 95.75564  ? 325 ASN F ND2 1 
ATOM   2019 N N   . THR A 1 291 ? 173.80101 375.65773 33.08060  1.000 92.68241  ? 326 THR F N   1 
ATOM   2020 C CA  . THR A 1 291 ? 173.04002 376.52396 32.19604  1.000 89.24720  ? 326 THR F CA  1 
ATOM   2021 C C   . THR A 1 291 ? 173.94393 377.23301 31.20479  1.000 88.38336  ? 326 THR F C   1 
ATOM   2022 O O   . THR A 1 291 ? 173.44131 377.85627 30.27155  1.000 97.46628  ? 326 THR F O   1 
ATOM   2023 C CB  . THR A 1 291 ? 172.21745 377.56367 32.99566  1.000 86.65180  ? 326 THR F CB  1 
ATOM   2024 O OG1 . THR A 1 291 ? 172.99292 378.09370 34.07893  1.000 95.36636  ? 326 THR F OG1 1 
ATOM   2025 C CG2 . THR A 1 291 ? 170.91871 376.95620 33.53448  1.000 80.73679  ? 326 THR F CG2 1 
ATOM   2026 N N   . LYS A 1 292 ? 175.25427 377.09081 31.33521  1.000 86.52681  ? 327 LYS F N   1 
ATOM   2027 C CA  . LYS A 1 292 ? 176.21945 377.70872 30.43313  1.000 90.81084  ? 327 LYS F CA  1 
ATOM   2028 C C   . LYS A 1 292 ? 176.86413 376.54530 29.70790  1.000 94.60691  ? 327 LYS F C   1 
ATOM   2029 O O   . LYS A 1 292 ? 177.51104 375.68602 30.32585  1.000 91.05084  ? 327 LYS F O   1 
ATOM   2030 C CB  . LYS A 1 292 ? 177.25529 378.58644 31.13649  1.000 90.10912  ? 327 LYS F CB  1 
ATOM   2031 C CG  . LYS A 1 292 ? 177.32101 378.52242 32.65818  1.000 87.56003  ? 327 LYS F CG  1 
ATOM   2032 C CD  . LYS A 1 292 ? 176.23384 379.49999 33.16862  1.000 95.49565  ? 327 LYS F CD  1 
ATOM   2033 C CE  . LYS A 1 292 ? 176.10858 379.74011 34.67937  1.000 93.08210  ? 327 LYS F CE  1 
ATOM   2034 N NZ  . LYS A 1 292 ? 175.03577 380.78220 34.86945  1.000 94.14058  ? 327 LYS F NZ  1 
ATOM   2035 N N   . GLU A 1 293 ? 176.62962 376.51537 28.40025  1.000 94.55596  ? 328 GLU F N   1 
ATOM   2036 C CA  . GLU A 1 293 ? 177.14451 375.47857 27.52390  1.000 99.33773  ? 328 GLU F CA  1 
ATOM   2037 C C   . GLU A 1 293 ? 178.65980 375.56493 27.36356  1.000 100.95717 ? 328 GLU F C   1 
ATOM   2038 O O   . GLU A 1 293 ? 179.22707 376.65893 27.29223  1.000 96.36324  ? 328 GLU F O   1 
ATOM   2039 C CB  . GLU A 1 293 ? 176.46201 375.60149 26.16160  1.000 104.85091 ? 328 GLU F CB  1 
ATOM   2040 C CG  . GLU A 1 293 ? 176.63340 374.37550 25.32539  1.000 110.26698 ? 328 GLU F CG  1 
ATOM   2041 C CD  . GLU A 1 293 ? 175.92191 373.20107 25.99064  1.000 107.01639 ? 328 GLU F CD  1 
ATOM   2042 O OE1 . GLU A 1 293 ? 174.82911 373.41933 26.57149  1.000 103.11564 ? 328 GLU F OE1 1 
ATOM   2043 O OE2 . GLU A 1 293 ? 176.47661 372.08076 25.99105  1.000 101.54619 ? 328 GLU F OE2 1 
ATOM   2044 N N   . GLY A 1 294 ? 179.32913 374.40356 27.34413  1.000 94.73335  ? 329 GLY F N   1 
ATOM   2045 C CA  . GLY A 1 294 ? 180.77052 374.39499 27.42929  1.000 88.52607  ? 329 GLY F CA  1 
ATOM   2046 C C   . GLY A 1 294 ? 181.32211 374.16195 28.81425  1.000 84.71631  ? 329 GLY F C   1 
ATOM   2047 O O   . GLY A 1 294 ? 182.53254 373.94825 28.95177  1.000 90.91819  ? 329 GLY F O   1 
ATOM   2048 N N   . SER A 1 295 ? 180.46493 374.10684 29.82927  1.000 75.00238  ? 330 SER F N   1 
ATOM   2049 C CA  . SER A 1 295 ? 180.88704 373.86226 31.20415  1.000 78.33617  ? 330 SER F CA  1 
ATOM   2050 C C   . SER A 1 295 ? 180.38542 372.53146 31.71530  1.000 65.07326  ? 330 SER F C   1 
ATOM   2051 O O   . SER A 1 295 ? 180.45553 372.26237 32.91919  1.000 70.77083  ? 330 SER F O   1 
ATOM   2052 C CB  . SER A 1 295 ? 180.38346 374.96393 32.14207  1.000 83.22066  ? 330 SER F CB  1 
ATOM   2053 O OG  . SER A 1 295 ? 178.95657 374.98465 32.21493  1.000 84.00649  ? 330 SER F OG  1 
ATOM   2054 N N   . ASN A 1 296 ? 179.99595 371.64655 30.82181  1.000 57.42242  ? 331 ASN F N   1 
ATOM   2055 C CA  . ASN A 1 296 ? 179.41162 370.41422 31.28815  1.000 62.60510  ? 331 ASN F CA  1 
ATOM   2056 C C   . ASN A 1 296 ? 180.33634 369.26432 30.92846  1.000 54.11609  ? 331 ASN F C   1 
ATOM   2057 O O   . ASN A 1 296 ? 181.00068 369.27476 29.88816  1.000 54.37957  ? 331 ASN F O   1 
ATOM   2058 C CB  . ASN A 1 296 ? 178.06710 370.21638 30.59166  1.000 54.36761  ? 331 ASN F CB  1 
ATOM   2059 C CG  . ASN A 1 296 ? 176.97511 371.01628 31.23990  1.000 59.78034  ? 331 ASN F CG  1 
ATOM   2060 O OD1 . ASN A 1 296 ? 176.84788 371.05770 32.46843  1.000 54.94836  ? 331 ASN F OD1 1 
ATOM   2061 N ND2 . ASN A 1 296 ? 176.14856 371.64358 30.40937  1.000 62.76049  ? 331 ASN F ND2 1 
ATOM   2062 N N   . ILE A 1 297 ? 180.36213 368.26734 31.80127  1.000 52.54366  ? 332 ILE F N   1 
ATOM   2063 C CA  . ILE A 1 297 ? 181.17958 367.08317 31.60140  1.000 52.39560  ? 332 ILE F CA  1 
ATOM   2064 C C   . ILE A 1 297 ? 180.29088 365.84920 31.59533  1.000 51.83657  ? 332 ILE F C   1 
ATOM   2065 O O   . ILE A 1 297 ? 179.24283 365.80220 32.24829  1.000 51.47684  ? 332 ILE F O   1 
ATOM   2066 C CB  . ILE A 1 297 ? 182.25650 366.95654 32.69051  1.000 52.75123  ? 332 ILE F CB  1 
ATOM   2067 C CG1 . ILE A 1 297 ? 181.58887 366.96522 34.06010  1.000 45.94176  ? 332 ILE F CG1 1 
ATOM   2068 C CG2 . ILE A 1 297 ? 183.30248 368.04486 32.51844  1.000 55.72472  ? 332 ILE F CG2 1 
ATOM   2069 C CD1 . ILE A 1 297 ? 182.55533 366.83648 35.18346  1.000 49.18334  ? 332 ILE F CD1 1 
ATOM   2070 N N   . CYS A 1 298 ? 180.71296 364.84600 30.82968  1.000 51.05151  ? 333 CYS F N   1 
ATOM   2071 C CA  . CYS A 1 298 ? 179.91236 363.65150 30.64385  1.000 46.84373  ? 333 CYS F CA  1 
ATOM   2072 C C   . CYS A 1 298 ? 180.70682 362.38774 30.96612  1.000 47.95606  ? 333 CYS F C   1 
ATOM   2073 O O   . CYS A 1 298 ? 181.92609 362.33985 30.87200  1.000 45.77941  ? 333 CYS F O   1 
ATOM   2074 C CB  . CYS A 1 298 ? 179.40985 363.57629 29.22348  1.000 50.22937  ? 333 CYS F CB  1 
ATOM   2075 S SG  . CYS A 1 298 ? 178.34389 364.94863 28.82334  1.000 50.57945  ? 333 CYS F SG  1 
ATOM   2076 N N   . LEU A 1 299 ? 179.96309 361.31783 31.16815  1.000 47.29335  ? 334 LEU F N   1 
ATOM   2077 C CA  . LEU A 1 299 ? 180.46733 360.02299 31.57230  1.000 47.07326  ? 334 LEU F CA  1 
ATOM   2078 C C   . LEU A 1 299 ? 179.46377 358.95978 31.13456  1.000 44.12238  ? 334 LEU F C   1 
ATOM   2079 O O   . LEU A 1 299 ? 178.26006 359.16967 31.28643  1.000 41.61011  ? 334 LEU F O   1 
ATOM   2080 C CB  . LEU A 1 299 ? 180.60547 360.02371 33.08197  1.000 44.47811  ? 334 LEU F CB  1 
ATOM   2081 C CG  . LEU A 1 299 ? 180.98922 358.86659 33.91863  1.000 53.97669  ? 334 LEU F CG  1 
ATOM   2082 C CD1 . LEU A 1 299 ? 181.65704 359.40490 35.20816  1.000 50.71973  ? 334 LEU F CD1 1 
ATOM   2083 C CD2 . LEU A 1 299 ? 179.68113 358.08966 34.16094  1.000 40.86305  ? 334 LEU F CD2 1 
ATOM   2084 N N   . THR A 1 300 ? 179.94992 357.83329 30.60618  1.000 40.88026  ? 335 THR F N   1 
ATOM   2085 C CA  . THR A 1 300 ? 179.08325 356.74335 30.17107  1.000 42.40498  ? 335 THR F CA  1 
ATOM   2086 C C   . THR A 1 300 ? 179.80027 355.45328 30.53875  1.000 44.37622  ? 335 THR F C   1 
ATOM   2087 O O   . THR A 1 300 ? 180.95526 355.23277 30.13948  1.000 43.89710  ? 335 THR F O   1 
ATOM   2088 C CB  . THR A 1 300 ? 178.80371 356.73150 28.65662  1.000 43.94416  ? 335 THR F CB  1 
ATOM   2089 O OG1 . THR A 1 300 ? 178.46254 358.04408 28.19405  1.000 42.68352  ? 335 THR F OG1 1 
ATOM   2090 C CG2 . THR A 1 300 ? 177.65589 355.72564 28.32638  1.000 34.68283  ? 335 THR F CG2 1 
ATOM   2091 N N   . ARG A 1 301 ? 179.06115 354.55605 31.18323  1.000 35.59199  ? 336 ARG F N   1 
ATOM   2092 C CA  . ARG A 1 301 ? 179.57132 353.22749 31.46336  1.000 42.28851  ? 336 ARG F CA  1 
ATOM   2093 C C   . ARG A 1 301 ? 179.78936 352.51286 30.14672  1.000 40.50801  ? 336 ARG F C   1 
ATOM   2094 O O   . ARG A 1 301 ? 178.97681 352.61003 29.22971  1.000 38.38913  ? 336 ARG F O   1 
ATOM   2095 C CB  . ARG A 1 301 ? 178.60882 352.41635 32.36291  1.000 37.67765  ? 336 ARG F CB  1 
ATOM   2096 C CG  . ARG A 1 301 ? 178.54723 352.88220 33.83404  1.000 39.94452  ? 336 ARG F CG  1 
ATOM   2097 C CD  . ARG A 1 301 ? 177.62951 351.93512 34.58276  1.000 40.34121  ? 336 ARG F CD  1 
ATOM   2098 N NE  . ARG A 1 301 ? 178.15480 350.58503 34.47170  1.000 39.65273  ? 336 ARG F NE  1 
ATOM   2099 C CZ  . ARG A 1 301 ? 177.57461 349.49864 34.96112  1.000 40.69546  ? 336 ARG F CZ  1 
ATOM   2100 N NH1 . ARG A 1 301 ? 176.42140 349.56627 35.60388  1.000 40.45817  ? 336 ARG F NH1 1 
ATOM   2101 N NH2 . ARG A 1 301 ? 178.14998 348.30690 34.75840  1.000 40.02197  ? 336 ARG F NH2 1 
ATOM   2102 N N   . THR A 1 302 ? 180.82214 351.70349 30.08453  1.000 41.08977  ? 337 THR F N   1 
ATOM   2103 C CA  . THR A 1 302 ? 181.08177 351.02259 28.83090  1.000 44.48197  ? 337 THR F CA  1 
ATOM   2104 C C   . THR A 1 302 ? 180.65859 349.56573 28.96134  1.000 38.02805  ? 337 THR F C   1 
ATOM   2105 O O   . THR A 1 302 ? 180.10359 349.12629 29.97764  1.000 38.09570  ? 337 THR F O   1 
ATOM   2106 C CB  . THR A 1 302 ? 182.57493 351.03563 28.50386  1.000 41.21887  ? 337 THR F CB  1 
ATOM   2107 O OG1 . THR A 1 302 ? 183.27928 350.44920 29.59597  1.000 46.77233  ? 337 THR F OG1 1 
ATOM   2108 C CG2 . THR A 1 302 ? 183.07183 352.42420 28.37689  1.000 48.31897  ? 337 THR F CG2 1 
ATOM   2109 N N   . ASP A 1 303 ? 180.84733 348.83677 27.87535  1.000 33.62280  ? 338 ASP F N   1 
ATOM   2110 C CA  . ASP A 1 303 ? 180.53988 347.41524 27.80382  1.000 40.73794  ? 338 ASP F CA  1 
ATOM   2111 C C   . ASP A 1 303 ? 179.07652 347.08439 28.05989  1.000 44.11633  ? 338 ASP F C   1 
ATOM   2112 O O   . ASP A 1 303 ? 178.74171 346.14777 28.79046  1.000 43.46117  ? 338 ASP F O   1 
ATOM   2113 C CB  . ASP A 1 303 ? 181.44512 346.63368 28.76652  1.000 47.03440  ? 338 ASP F CB  1 
ATOM   2114 C CG  . ASP A 1 303 ? 182.90562 346.76592 28.40284  1.000 49.17385  ? 338 ASP F CG  1 
ATOM   2115 O OD1 . ASP A 1 303 ? 183.15342 346.92980 27.18777  1.000 52.34456  ? 338 ASP F OD1 1 
ATOM   2116 O OD2 . ASP A 1 303 ? 183.78647 346.70363 29.29533  1.000 58.51350  ? 338 ASP F OD2 1 
ATOM   2117 N N   . ARG A 1 304 ? 178.23906 347.68595 27.23943  1.000 36.46191  ? 339 ARG F N   1 
ATOM   2118 C CA  . ARG A 1 304 ? 176.84461 347.34741 27.27577  1.000 38.19795  ? 339 ARG F CA  1 
ATOM   2119 C C   . ARG A 1 304 ? 176.64262 346.12832 26.40806  1.000 35.01935  ? 339 ARG F C   1 
ATOM   2120 O O   . ARG A 1 304 ? 177.48597 345.81789 25.56112  1.000 37.46258  ? 339 ARG F O   1 
ATOM   2121 C CB  . ARG A 1 304 ? 176.03686 348.52461 26.72537  1.000 39.97968  ? 339 ARG F CB  1 
ATOM   2122 C CG  . ARG A 1 304 ? 176.36571 348.87838 25.25497  1.000 41.69053  ? 339 ARG F CG  1 
ATOM   2123 C CD  . ARG A 1 304 ? 175.29860 349.75672 24.66224  1.000 46.80447  ? 339 ARG F CD  1 
ATOM   2124 N NE  . ARG A 1 304 ? 175.33139 351.11795 25.20755  1.000 51.40475  ? 339 ARG F NE  1 
ATOM   2125 C CZ  . ARG A 1 304 ? 175.89949 352.19730 24.68524  1.000 57.46979  ? 339 ARG F CZ  1 
ATOM   2126 N NH1 . ARG A 1 304 ? 176.54680 352.14976 23.53003  1.000 55.56127  ? 339 ARG F NH1 1 
ATOM   2127 N NH2 . ARG A 1 304 ? 175.77061 353.37201 25.32717  1.000 46.05824  ? 339 ARG F NH2 1 
ATOM   2128 N N   . GLY A 1 305 ? 175.69530 345.30965 26.80954  1.000 33.30936  ? 340 GLY F N   1 
ATOM   2129 C CA  . GLY A 1 305 ? 175.35197 344.08354 26.09375  1.000 39.56323  ? 340 GLY F CA  1 
ATOM   2130 C C   . GLY A 1 305 ? 174.90070 342.97593 27.05581  1.000 38.93233  ? 340 GLY F C   1 
ATOM   2131 O O   . GLY A 1 305 ? 174.65856 343.22813 28.24273  1.000 35.01548  ? 340 GLY F O   1 
ATOM   2132 N N   . TRP A 1 306 ? 175.07729 341.73880 26.58598  1.000 34.01225  ? 341 TRP F N   1 
ATOM   2133 C CA  . TRP A 1 306 ? 174.64965 340.52836 27.29004  1.000 35.96035  ? 341 TRP F CA  1 
ATOM   2134 C C   . TRP A 1 306 ? 175.79289 339.94173 28.10469  1.000 36.00102  ? 341 TRP F C   1 
ATOM   2135 O O   . TRP A 1 306 ? 176.92679 339.86117 27.62730  1.000 35.23801  ? 341 TRP F O   1 
ATOM   2136 C CB  . TRP A 1 306 ? 174.13815 339.45682 26.32714  1.000 36.34866  ? 341 TRP F CB  1 
ATOM   2137 C CG  . TRP A 1 306 ? 172.74952 339.68661 25.89305  1.000 36.34953  ? 341 TRP F CG  1 
ATOM   2138 C CD1 . TRP A 1 306 ? 172.33999 340.18816 24.67008  1.000 35.12754  ? 341 TRP F CD1 1 
ATOM   2139 C CD2 . TRP A 1 306 ? 171.56445 339.48056 26.66254  1.000 35.74022  ? 341 TRP F CD2 1 
ATOM   2140 N NE1 . TRP A 1 306 ? 170.96630 340.29881 24.65281  1.000 40.67296  ? 341 TRP F NE1 1 
ATOM   2141 C CE2 . TRP A 1 306 ? 170.46786 339.87429 25.85919  1.000 37.49032  ? 341 TRP F CE2 1 
ATOM   2142 C CE3 . TRP A 1 306 ? 171.31806 339.02712 27.96271  1.000 41.16797  ? 341 TRP F CE3 1 
ATOM   2143 C CZ2 . TRP A 1 306 ? 169.15336 339.79096 26.30330  1.000 41.96994  ? 341 TRP F CZ2 1 
ATOM   2144 C CZ3 . TRP A 1 306 ? 170.00406 338.94512 28.40772  1.000 37.33517  ? 341 TRP F CZ3 1 
ATOM   2145 C CH2 . TRP A 1 306 ? 168.93809 339.33107 27.58516  1.000 41.49734  ? 341 TRP F CH2 1 
ATOM   2146 N N   . TYR A 1 307 ? 175.48165 339.59596 29.35179  1.000 37.36064  ? 342 TYR F N   1 
ATOM   2147 C CA  . TYR A 1 307 ? 176.33891 338.88967 30.30366  1.000 39.22413  ? 342 TYR F CA  1 
ATOM   2148 C C   . TYR A 1 307 ? 175.70690 337.58428 30.76878  1.000 42.91171  ? 342 TYR F C   1 
ATOM   2149 O O   . TYR A 1 307 ? 174.50335 337.54810 31.05425  1.000 37.50515  ? 342 TYR F O   1 
ATOM   2150 C CB  . TYR A 1 307 ? 176.62020 339.74481 31.54082  1.000 37.75816  ? 342 TYR F CB  1 
ATOM   2151 C CG  . TYR A 1 307 ? 177.38475 340.97863 31.22819  1.000 39.12215  ? 342 TYR F CG  1 
ATOM   2152 C CD1 . TYR A 1 307 ? 176.76013 342.07443 30.63797  1.000 32.25497  ? 342 TYR F CD1 1 
ATOM   2153 C CD2 . TYR A 1 307 ? 178.73092 341.07631 31.57192  1.000 34.77669  ? 342 TYR F CD2 1 
ATOM   2154 C CE1 . TYR A 1 307 ? 177.49241 343.22002 30.35530  1.000 37.29871  ? 342 TYR F CE1 1 
ATOM   2155 C CE2 . TYR A 1 307 ? 179.44863 342.21157 31.32777  1.000 36.84950  ? 342 TYR F CE2 1 
ATOM   2156 C CZ  . TYR A 1 307 ? 178.81442 343.28278 30.71056  1.000 34.31106  ? 342 TYR F CZ  1 
ATOM   2157 O OH  . TYR A 1 307 ? 179.54158 344.38708 30.43659  1.000 41.45318  ? 342 TYR F OH  1 
ATOM   2158 N N   . CYS A 1 308 ? 176.49517 336.50275 30.77885  1.000 40.50202  ? 343 CYS F N   1 
ATOM   2159 C CA  . CYS A 1 308 ? 176.00837 335.21775 31.26250  1.000 37.90791  ? 343 CYS F CA  1 
ATOM   2160 C C   . CYS A 1 308 ? 177.05934 334.57582 32.15281  1.000 40.79732  ? 343 CYS F C   1 
ATOM   2161 O O   . CYS A 1 308 ? 178.25519 334.64654 31.85785  1.000 39.94722  ? 343 CYS F O   1 
ATOM   2162 C CB  . CYS A 1 308 ? 175.65957 334.23714 30.15070  1.000 44.44868  ? 343 CYS F CB  1 
ATOM   2163 S SG  . CYS A 1 308 ? 174.33645 334.74379 29.03666  1.000 47.44735  ? 343 CYS F SG  1 
ATOM   2164 N N   . ASP A 1 309 ? 176.59445 333.94950 33.23842  1.000 40.56311  ? 344 ASP F N   1 
ATOM   2165 C CA  . ASP A 1 309 ? 177.47267 333.16258 34.09584  1.000 44.29470  ? 344 ASP F CA  1 
ATOM   2166 C C   . ASP A 1 309 ? 177.97192 331.97706 33.28459  1.000 46.30646  ? 344 ASP F C   1 
ATOM   2167 O O   . ASP A 1 309 ? 177.19906 331.35399 32.54529  1.000 38.27140  ? 344 ASP F O   1 
ATOM   2168 C CB  . ASP A 1 309 ? 176.73319 332.59871 35.31549  1.000 41.42468  ? 344 ASP F CB  1 
ATOM   2169 C CG  . ASP A 1 309 ? 176.38220 333.65527 36.32520  1.000 50.64887  ? 344 ASP F CG  1 
ATOM   2170 O OD1 . ASP A 1 309 ? 177.18380 334.58086 36.47383  1.000 50.05906  ? 344 ASP F OD1 1 
ATOM   2171 O OD2 . ASP A 1 309 ? 175.34355 333.52470 37.01721  1.000 56.22447  ? 344 ASP F OD2 1 
ATOM   2172 N N   . ASN A 1 310 ? 179.27681 331.73565 33.31646  1.000 38.64540  ? 345 ASN F N   1 
ATOM   2173 C CA  . ASN A 1 310 ? 179.80885 330.66734 32.48708  1.000 38.66406  ? 345 ASN F CA  1 
ATOM   2174 C C   . ASN A 1 310 ? 181.08234 330.10298 33.09710  1.000 37.90300  ? 345 ASN F C   1 
ATOM   2175 O O   . ASN A 1 310 ? 182.12852 330.76278 33.07891  1.000 37.78754  ? 345 ASN F O   1 
ATOM   2176 C CB  . ASN A 1 310 ? 180.04849 331.16476 31.05648  1.000 38.77013  ? 345 ASN F CB  1 
ATOM   2177 C CG  . ASN A 1 310 ? 180.42106 330.02125 30.12382  1.000 43.47182  ? 345 ASN F CG  1 
ATOM   2178 O OD1 . ASN A 1 310 ? 180.34205 328.86338 30.52721  1.000 38.55604  ? 345 ASN F OD1 1 
ATOM   2179 N ND2 . ASN A 1 310 ? 180.82530 330.32908 28.89182  1.000 39.72915  ? 345 ASN F ND2 1 
ATOM   2180 N N   . ALA A 1 311 ? 180.99450 328.91097 33.68145  1.000 41.45502  ? 346 ALA F N   1 
ATOM   2181 C CA  . ALA A 1 311 ? 182.18615 328.15920 34.11388  1.000 34.57310  ? 346 ALA F CA  1 
ATOM   2182 C C   . ALA A 1 311 ? 183.06396 328.96851 35.07315  1.000 31.97113  ? 346 ALA F C   1 
ATOM   2183 O O   . ALA A 1 311 ? 184.28594 329.03962 34.92350  1.000 40.17642  ? 346 ALA F O   1 
ATOM   2184 C CB  . ALA A 1 311 ? 182.99498 327.68359 32.90860  1.000 35.54160  ? 346 ALA F CB  1 
ATOM   2185 N N   . GLY A 1 312 ? 182.45484 329.51201 36.11918  1.000 37.62961  ? 347 GLY F N   1 
ATOM   2186 C CA  . GLY A 1 312 ? 183.22086 330.25499 37.10243  1.000 44.97377  ? 347 GLY F CA  1 
ATOM   2187 C C   . GLY A 1 312 ? 183.60823 331.65692 36.68604  1.000 48.74810  ? 347 GLY F C   1 
ATOM   2188 O O   . GLY A 1 312 ? 184.17705 332.39594 37.50203  1.000 46.38226  ? 347 GLY F O   1 
ATOM   2189 N N   . SER A 1 313 ? 183.34073 332.03392 35.44289  1.000 45.20339  ? 348 SER F N   1 
ATOM   2190 C CA  . SER A 1 313 ? 183.57741 333.35929 34.91885  1.000 43.89355  ? 348 SER F CA  1 
ATOM   2191 C C   . SER A 1 313 ? 182.25191 333.89174 34.37220  1.000 42.77724  ? 348 SER F C   1 
ATOM   2192 O O   . SER A 1 313 ? 181.17249 333.30586 34.59360  1.000 38.29853  ? 348 SER F O   1 
ATOM   2193 C CB  . SER A 1 313 ? 184.64482 333.34278 33.82777  1.000 43.38326  ? 348 SER F CB  1 
ATOM   2194 O OG  . SER A 1 313 ? 185.90895 332.99660 34.30608  1.000 46.45289  ? 348 SER F OG  1 
ATOM   2195 N N   . VAL A 1 314 ? 182.33204 335.06119 33.74846  1.000 42.20278  ? 349 VAL F N   1 
ATOM   2196 C CA  . VAL A 1 314 ? 181.20614 335.70611 33.07463  1.000 42.94933  ? 349 VAL F CA  1 
ATOM   2197 C C   . VAL A 1 314 ? 181.52883 335.81498 31.58836  1.000 41.03627  ? 349 VAL F C   1 
ATOM   2198 O O   . VAL A 1 314 ? 182.58467 336.34202 31.21295  1.000 40.57782  ? 349 VAL F O   1 
ATOM   2199 C CB  . VAL A 1 314 ? 180.88046 337.08041 33.67748  1.000 41.75688  ? 349 VAL F CB  1 
ATOM   2200 C CG1 . VAL A 1 314 ? 179.79734 337.76231 32.85054  1.000 43.85978  ? 349 VAL F CG1 1 
ATOM   2201 C CG2 . VAL A 1 314 ? 180.38979 336.91125 35.10585  1.000 41.98040  ? 349 VAL F CG2 1 
ATOM   2202 N N   . SER A 1 315 ? 180.63157 335.33894 30.75122  1.000 34.38802  ? 350 SER F N   1 
ATOM   2203 C CA  . SER A 1 315 ? 180.76994 335.48846 29.30759  1.000 39.98460  ? 350 SER F CA  1 
ATOM   2204 C C   . SER A 1 315 ? 180.04226 336.75726 28.86526  1.000 37.62025  ? 350 SER F C   1 
ATOM   2205 O O   . SER A 1 315 ? 178.87918 336.94318 29.21519  1.000 36.20572  ? 350 SER F O   1 
ATOM   2206 C CB  . SER A 1 315 ? 180.18847 334.30044 28.54548  1.000 38.80021  ? 350 SER F CB  1 
ATOM   2207 O OG  . SER A 1 315 ? 181.02679 333.17859 28.65202  1.000 43.39130  ? 350 SER F OG  1 
ATOM   2208 N N   . PHE A 1 316 ? 180.79056 337.71280 28.31857  1.000 39.31899  ? 351 PHE F N   1 
ATOM   2209 C CA  . PHE A 1 316 ? 180.25731 338.96680 27.79741  1.000 33.97991  ? 351 PHE F CA  1 
ATOM   2210 C C   . PHE A 1 316 ? 180.15088 338.94944 26.27191  1.000 41.17414  ? 351 PHE F C   1 
ATOM   2211 O O   . PHE A 1 316 ? 181.11535 338.58918 25.58118  1.000 36.67762  ? 351 PHE F O   1 
ATOM   2212 C CB  . PHE A 1 316 ? 181.15221 340.11163 28.27637  1.000 33.71461  ? 351 PHE F CB  1 
ATOM   2213 C CG  . PHE A 1 316 ? 180.86626 341.43088 27.65094  1.000 39.67353  ? 351 PHE F CG  1 
ATOM   2214 C CD1 . PHE A 1 316 ? 179.61596 342.01192 27.74302  1.000 38.72362  ? 351 PHE F CD1 1 
ATOM   2215 C CD2 . PHE A 1 316 ? 181.89975 342.16679 27.09046  1.000 38.25211  ? 351 PHE F CD2 1 
ATOM   2216 C CE1 . PHE A 1 316 ? 179.37692 343.23962 27.16655  1.000 40.91807  ? 351 PHE F CE1 1 
ATOM   2217 C CE2 . PHE A 1 316 ? 181.66256 343.39388 26.54376  1.000 40.89544  ? 351 PHE F CE2 1 
ATOM   2218 C CZ  . PHE A 1 316 ? 180.39552 343.93108 26.56948  1.000 35.08533  ? 351 PHE F CZ  1 
ATOM   2219 N N   . PHE A 1 317 ? 179.01088 339.40552 25.74155  1.000 37.96312  ? 352 PHE F N   1 
ATOM   2220 C CA  . PHE A 1 317 ? 178.80073 339.42628 24.29043  1.000 37.37533  ? 352 PHE F CA  1 
ATOM   2221 C C   . PHE A 1 317 ? 178.62281 340.86569 23.84676  1.000 41.44125  ? 352 PHE F C   1 
ATOM   2222 O O   . PHE A 1 317 ? 177.49581 341.39726 23.88361  1.000 46.30791  ? 352 PHE F O   1 
ATOM   2223 C CB  . PHE A 1 317 ? 177.58419 338.58541 23.93350  1.000 35.70422  ? 352 PHE F CB  1 
ATOM   2224 C CG  . PHE A 1 317 ? 177.65461 337.22221 24.50080  1.000 42.42912  ? 352 PHE F CG  1 
ATOM   2225 C CD1 . PHE A 1 317 ? 177.16200 336.95865 25.77616  1.000 42.72538  ? 352 PHE F CD1 1 
ATOM   2226 C CD2 . PHE A 1 317 ? 178.18560 336.17906 23.75851  1.000 42.65422  ? 352 PHE F CD2 1 
ATOM   2227 C CE1 . PHE A 1 317 ? 177.23920 335.67187 26.31189  1.000 48.17686  ? 352 PHE F CE1 1 
ATOM   2228 C CE2 . PHE A 1 317 ? 178.25357 334.89216 24.28579  1.000 41.75242  ? 352 PHE F CE2 1 
ATOM   2229 C CZ  . PHE A 1 317 ? 177.77915 334.63402 25.55668  1.000 41.02203  ? 352 PHE F CZ  1 
ATOM   2230 N N   . PRO A 1 318 ? 179.66437 341.49422 23.31646  1.000 41.78949  ? 353 PRO F N   1 
ATOM   2231 C CA  . PRO A 1 318 ? 179.54411 342.91568 22.93156  1.000 45.51018  ? 353 PRO F CA  1 
ATOM   2232 C C   . PRO A 1 318 ? 178.73609 343.14304 21.65948  1.000 52.60690  ? 353 PRO F C   1 
ATOM   2233 O O   . PRO A 1 318 ? 178.05893 344.17309 21.56034  1.000 60.62856  ? 353 PRO F O   1 
ATOM   2234 C CB  . PRO A 1 318 ? 181.00889 343.35975 22.78456  1.000 47.42728  ? 353 PRO F CB  1 
ATOM   2235 C CG  . PRO A 1 318 ? 181.76141 342.07809 22.45225  1.000 42.06898  ? 353 PRO F CG  1 
ATOM   2236 C CD  . PRO A 1 318 ? 181.04101 340.97818 23.20033  1.000 36.79363  ? 353 PRO F CD  1 
ATOM   2237 N N   . GLN A 1 319 ? 178.87431 342.27861 20.65081  1.000 51.38656  ? 354 GLN F N   1 
ATOM   2238 C CA  . GLN A 1 319 ? 178.13374 342.39045 19.38934  1.000 51.40771  ? 354 GLN F CA  1 
ATOM   2239 C C   . GLN A 1 319 ? 176.65813 342.04557 19.54136  1.000 54.18193  ? 354 GLN F C   1 
ATOM   2240 O O   . GLN A 1 319 ? 176.29873 341.01080 20.11206  1.000 53.59287  ? 354 GLN F O   1 
ATOM   2241 C CB  . GLN A 1 319 ? 178.76347 341.50723 18.33343  1.000 56.12933  ? 354 GLN F CB  1 
ATOM   2242 C CG  . GLN A 1 319 ? 179.96371 342.15079 17.69504  1.000 63.20620  ? 354 GLN F CG  1 
ATOM   2243 C CD  . GLN A 1 319 ? 181.25058 341.41124 18.01694  1.000 77.12993  ? 354 GLN F CD  1 
ATOM   2244 O OE1 . GLN A 1 319 ? 181.46395 340.28139 17.55563  1.000 79.80845  ? 354 GLN F OE1 1 
ATOM   2245 N NE2 . GLN A 1 319 ? 182.12722 342.05206 18.81501  1.000 73.66915  ? 354 GLN F NE2 1 
ATOM   2246 N N   . ALA A 1 320 ? 175.81822 342.76732 18.80620  1.000 66.61769  ? 355 ALA F N   1 
ATOM   2247 C CA  . ALA A 1 320 ? 174.37245 342.66035 19.00339  1.000 61.94940  ? 355 ALA F CA  1 
ATOM   2248 C C   . ALA A 1 320 ? 173.78253 341.39638 18.39053  1.000 66.18038  ? 355 ALA F C   1 
ATOM   2249 O O   . ALA A 1 320 ? 172.79294 340.86050 18.90338  1.000 67.17539  ? 355 ALA F O   1 
ATOM   2250 C CB  . ALA A 1 320 ? 173.68710 343.89631 18.41851  1.000 63.92874  ? 355 ALA F CB  1 
ATOM   2251 N N   . GLU A 1 321 ? 174.36695 340.87593 17.33656  1.000 62.66505  ? 356 GLU F N   1 
ATOM   2252 C CA  . GLU A 1 321 ? 173.75737 339.71821 16.71149  1.000 73.26626  ? 356 GLU F CA  1 
ATOM   2253 C C   . GLU A 1 321 ? 174.20597 338.40144 17.33678  1.000 69.61484  ? 356 GLU F C   1 
ATOM   2254 O O   . GLU A 1 321 ? 173.71969 337.34115 16.92545  1.000 73.18416  ? 356 GLU F O   1 
ATOM   2255 C CB  . GLU A 1 321 ? 174.07587 339.72087 15.20607  1.000 80.45499  ? 356 GLU F CB  1 
ATOM   2256 C CG  . GLU A 1 321 ? 173.29893 338.68466 14.37608  1.000 90.46559  ? 356 GLU F CG  1 
ATOM   2257 C CD  . GLU A 1 321 ? 172.43117 339.30796 13.26417  1.000 98.19946  ? 356 GLU F CD  1 
ATOM   2258 O OE1 . GLU A 1 321 ? 172.37405 340.55675 13.16597  1.000 100.52246 ? 356 GLU F OE1 1 
ATOM   2259 O OE2 . GLU A 1 321 ? 171.80645 338.54164 12.48855  1.000 95.94757  ? 356 GLU F OE2 1 
ATOM   2260 N N   . THR A 1 322 ? 175.05578 338.42399 18.36265  1.000 60.96489  ? 357 THR F N   1 
ATOM   2261 C CA  . THR A 1 322 ? 175.49910 337.14903 18.91402  1.000 52.70002  ? 357 THR F CA  1 
ATOM   2262 C C   . THR A 1 322 ? 174.56934 336.49738 19.91975  1.000 56.42496  ? 357 THR F C   1 
ATOM   2263 O O   . THR A 1 322 ? 174.78197 335.31474 20.22558  1.000 59.91583  ? 357 THR F O   1 
ATOM   2264 C CB  . THR A 1 322 ? 176.83019 337.38550 19.65191  1.000 56.23815  ? 357 THR F CB  1 
ATOM   2265 O OG1 . THR A 1 322 ? 177.80867 337.95022 18.76625  1.000 68.26977  ? 357 THR F OG1 1 
ATOM   2266 C CG2 . THR A 1 322 ? 177.35596 336.10179 20.36896  1.000 48.42730  ? 357 THR F CG2 1 
ATOM   2267 N N   . CYS A 1 323 ? 173.46109 337.11815 20.28407  1.000 45.82507  ? 358 CYS F N   1 
ATOM   2268 C CA  . CYS A 1 323 ? 172.54593 336.52645 21.24685  1.000 52.59648  ? 358 CYS F CA  1 
ATOM   2269 C C   . CYS A 1 323 ? 171.13615 336.71333 20.73432  1.000 48.92748  ? 358 CYS F C   1 
ATOM   2270 O O   . CYS A 1 323 ? 170.75033 337.82776 20.37600  1.000 47.85676  ? 358 CYS F O   1 
ATOM   2271 C CB  . CYS A 1 323 ? 172.68348 337.11461 22.66999  1.000 44.92907  ? 358 CYS F CB  1 
ATOM   2272 S SG  . CYS A 1 323 ? 174.19869 336.66041 23.60749  1.000 51.12449  ? 358 CYS F SG  1 
ATOM   2273 N N   . LYS A 1 324 ? 170.46743 335.60828 20.50266  1.000 48.64851  ? 359 LYS F N   1 
ATOM   2274 C CA  . LYS A 1 324 ? 169.07985 335.62157 20.10281  1.000 51.16165  ? 359 LYS F CA  1 
ATOM   2275 C C   . LYS A 1 324 ? 168.24538 335.41350 21.34444  1.000 48.41420  ? 359 LYS F C   1 
ATOM   2276 O O   . LYS A 1 324 ? 168.56734 334.57556 22.18574  1.000 48.79664  ? 359 LYS F O   1 
ATOM   2277 C CB  . LYS A 1 324 ? 168.80972 334.54077 19.06721  1.000 46.32301  ? 359 LYS F CB  1 
ATOM   2278 C CG  . LYS A 1 324 ? 169.90321 334.52318 18.02838  1.000 53.41311  ? 359 LYS F CG  1 
ATOM   2279 C CD  . LYS A 1 324 ? 169.62857 335.56070 16.95996  1.000 52.83593  ? 359 LYS F CD  1 
ATOM   2280 C CE  . LYS A 1 324 ? 170.43864 335.27198 15.70509  1.000 67.22740  ? 359 LYS F CE  1 
ATOM   2281 N NZ  . LYS A 1 324 ? 171.38356 336.39011 15.42357  1.000 74.03000  ? 359 LYS F NZ  1 
ATOM   2282 N N   . VAL A 1 325 ? 167.19730 336.20311 21.47651  1.000 46.51968  ? 360 VAL F N   1 
ATOM   2283 C CA  . VAL A 1 325 ? 166.35076 336.17679 22.64982  1.000 44.94206  ? 360 VAL F CA  1 
ATOM   2284 C C   . VAL A 1 325 ? 164.97143 335.69822 22.25397  1.000 52.68155  ? 360 VAL F C   1 
ATOM   2285 O O   . VAL A 1 325 ? 164.42568 336.13067 21.23440  1.000 59.78825  ? 360 VAL F O   1 
ATOM   2286 C CB  . VAL A 1 325 ? 166.27055 337.56240 23.30026  1.000 41.27951  ? 360 VAL F CB  1 
ATOM   2287 C CG1 . VAL A 1 325 ? 165.43822 337.50160 24.56555  1.000 50.32579  ? 360 VAL F CG1 1 
ATOM   2288 C CG2 . VAL A 1 325 ? 167.65909 338.06617 23.59152  1.000 44.85795  ? 360 VAL F CG2 1 
ATOM   2289 N N   . GLN A 1 326 ? 164.43261 334.78458 23.04651  1.000 54.46134  ? 361 GLN F N   1 
ATOM   2290 C CA  . GLN A 1 326 ? 163.05177 334.32757 22.97094  1.000 60.23587  ? 361 GLN F CA  1 
ATOM   2291 C C   . GLN A 1 326 ? 162.41805 334.41003 24.35823  1.000 63.83814  ? 361 GLN F C   1 
ATOM   2292 O O   . GLN A 1 326 ? 162.80607 333.67597 25.27709  1.000 58.41020  ? 361 GLN F O   1 
ATOM   2293 C CB  . GLN A 1 326 ? 162.95834 332.92289 22.40762  1.000 64.40865  ? 361 GLN F CB  1 
ATOM   2294 C CG  . GLN A 1 326 ? 161.71716 332.76559 21.60408  1.000 77.74522  ? 361 GLN F CG  1 
ATOM   2295 C CD  . GLN A 1 326 ? 160.63728 332.18228 22.48717  1.000 83.83048  ? 361 GLN F CD  1 
ATOM   2296 O OE1 . GLN A 1 326 ? 160.83379 331.12359 23.09843  1.000 82.79645  ? 361 GLN F OE1 1 
ATOM   2297 N NE2 . GLN A 1 326 ? 159.53591 332.92124 22.65241  1.000 84.65257  ? 361 GLN F NE2 1 
ATOM   2298 N N   . SER A 1 327 ? 161.43292 335.28753 24.50661  1.000 61.42067  ? 362 SER F N   1 
ATOM   2299 C CA  . SER A 1 327 ? 160.84668 335.56225 25.81231  1.000 65.27613  ? 362 SER F CA  1 
ATOM   2300 C C   . SER A 1 327 ? 161.88623 335.63936 26.93627  1.000 61.89379  ? 362 SER F C   1 
ATOM   2301 O O   . SER A 1 327 ? 162.71323 336.55092 26.97769  1.000 59.48151  ? 362 SER F O   1 
ATOM   2302 C CB  . SER A 1 327 ? 159.77034 334.51042 26.14262  1.000 66.11549  ? 362 SER F CB  1 
ATOM   2303 O OG  . SER A 1 327 ? 160.33361 333.21940 26.29939  1.000 72.01404  ? 362 SER F OG  1 
ATOM   2304 N N   . ASN A 1 328 ? 161.76550 334.72976 27.89620  1.000 68.24196  ? 363 ASN F N   1 
ATOM   2305 C CA  . ASN A 1 328 ? 162.65766 334.48016 29.02370  1.000 58.05459  ? 363 ASN F CA  1 
ATOM   2306 C C   . ASN A 1 328 ? 164.07612 333.98529 28.66747  1.000 52.61743  ? 363 ASN F C   1 
ATOM   2307 O O   . ASN A 1 328 ? 164.93555 333.94775 29.55402  1.000 47.58055  ? 363 ASN F O   1 
ATOM   2308 C CB  . ASN A 1 328 ? 161.89423 333.46713 29.88514  1.000 65.59698  ? 363 ASN F CB  1 
ATOM   2309 C CG  . ASN A 1 328 ? 162.55976 333.17645 31.17038  1.000 68.12996  ? 363 ASN F CG  1 
ATOM   2310 O OD1 . ASN A 1 328 ? 162.10721 332.32447 31.92606  1.000 70.14609  ? 363 ASN F OD1 1 
ATOM   2311 N ND2 . ASN A 1 328 ? 163.58920 333.95307 31.49374  1.000 73.72050  ? 363 ASN F ND2 1 
ATOM   2312 N N   . ARG A 1 329 ? 164.34436 333.54547 27.43951  1.000 50.85112  ? 364 ARG F N   1 
ATOM   2313 C CA  . ARG A 1 329 ? 165.52900 332.74128 27.15530  1.000 48.48316  ? 364 ARG F CA  1 
ATOM   2314 C C   . ARG A 1 329 ? 166.47747 333.40753 26.16025  1.000 52.68909  ? 364 ARG F C   1 
ATOM   2315 O O   . ARG A 1 329 ? 166.04620 334.12272 25.25103  1.000 48.11171  ? 364 ARG F O   1 
ATOM   2316 C CB  . ARG A 1 329 ? 165.12923 331.37416 26.59423  1.000 51.45834  ? 364 ARG F CB  1 
ATOM   2317 C CG  . ARG A 1 329 ? 164.04423 330.68300 27.40682  1.000 58.82253  ? 364 ARG F CG  1 
ATOM   2318 C CD  . ARG A 1 329 ? 164.15163 329.16126 27.31908  1.000 61.59525  ? 364 ARG F CD  1 
ATOM   2319 N NE  . ARG A 1 329 ? 165.52572 328.72545 27.52603  1.000 74.89040  ? 364 ARG F NE  1 
ATOM   2320 C CZ  . ARG A 1 329 ? 165.91466 327.92352 28.50960  1.000 71.14003  ? 364 ARG F CZ  1 
ATOM   2321 N NH1 . ARG A 1 329 ? 165.03650 327.41328 29.36943  1.000 58.87975  ? 364 ARG F NH1 1 
ATOM   2322 N NH2 . ARG A 1 329 ? 167.21636 327.64491 28.64222  1.000 62.61816  ? 364 ARG F NH2 1 
ATOM   2323 N N   . VAL A 1 330 ? 167.77820 333.12003 26.30443  1.000 42.96364  ? 365 VAL F N   1 
ATOM   2324 C CA  . VAL A 1 330 ? 168.81986 333.69591 25.46430  1.000 40.91120  ? 365 VAL F CA  1 
ATOM   2325 C C   . VAL A 1 330 ? 169.68911 332.57049 24.94203  1.000 44.76894  ? 365 VAL F C   1 
ATOM   2326 O O   . VAL A 1 330 ? 170.06307 331.66924 25.70086  1.000 51.93568  ? 365 VAL F O   1 
ATOM   2327 C CB  . VAL A 1 330 ? 169.66689 334.71718 26.24575  1.000 44.94460  ? 365 VAL F CB  1 
ATOM   2328 C CG1 . VAL A 1 330 ? 170.43180 335.58866 25.28711  1.000 42.54060  ? 365 VAL F CG1 1 
ATOM   2329 C CG2 . VAL A 1 330 ? 168.77960 335.54077 27.07716  1.000 47.43951  ? 365 VAL F CG2 1 
ATOM   2330 N N   . PHE A 1 331 ? 170.04668 332.64846 23.65768  1.000 46.76088  ? 366 PHE F N   1 
ATOM   2331 C CA  . PHE A 1 331 ? 170.87526 331.66758 22.95709  1.000 42.64557  ? 366 PHE F CA  1 
ATOM   2332 C C   . PHE A 1 331 ? 172.09593 332.38337 22.41381  1.000 47.24038  ? 366 PHE F C   1 
ATOM   2333 O O   . PHE A 1 331 ? 171.96892 333.22714 21.52501  1.000 50.15762  ? 366 PHE F O   1 
ATOM   2334 C CB  . PHE A 1 331 ? 170.07819 331.05132 21.82429  1.000 42.99221  ? 366 PHE F CB  1 
ATOM   2335 C CG  . PHE A 1 331 ? 168.95979 330.19853 22.29552  1.000 43.14847  ? 366 PHE F CG  1 
ATOM   2336 C CD1 . PHE A 1 331 ? 167.76564 330.77932 22.66713  1.000 40.60958  ? 366 PHE F CD1 1 
ATOM   2337 C CD2 . PHE A 1 331 ? 169.08114 328.82083 22.33765  1.000 48.53021  ? 366 PHE F CD2 1 
ATOM   2338 C CE1 . PHE A 1 331 ? 166.71907 330.02197 23.08385  1.000 45.80121  ? 366 PHE F CE1 1 
ATOM   2339 C CE2 . PHE A 1 331 ? 168.02833 328.04366 22.75788  1.000 44.59165  ? 366 PHE F CE2 1 
ATOM   2340 C CZ  . PHE A 1 331 ? 166.84284 328.65047 23.12740  1.000 49.71286  ? 366 PHE F CZ  1 
ATOM   2341 N N   . CYS A 1 332 ? 173.24001 332.18169 23.03791  1.000 45.57039  ? 367 CYS F N   1 
ATOM   2342 C CA  . CYS A 1 332 ? 174.44912 332.87289 22.63078  1.000 45.02516  ? 367 CYS F CA  1 
ATOM   2343 C C   . CYS A 1 332 ? 175.47692 331.87174 22.10408  1.000 45.38445  ? 367 CYS F C   1 
ATOM   2344 O O   . CYS A 1 332 ? 175.46659 330.68879 22.45796  1.000 48.46114  ? 367 CYS F O   1 
ATOM   2345 C CB  . CYS A 1 332 ? 174.99734 333.64015 23.83650  1.000 39.25963  ? 367 CYS F CB  1 
ATOM   2346 S SG  . CYS A 1 332 ? 173.82172 334.83946 24.51905  1.000 51.91469  ? 367 CYS F SG  1 
ATOM   2347 N N   . ASP A 1 333 ? 176.44110 332.36782 21.35436  1.000 49.93802  ? 368 ASP F N   1 
ATOM   2348 C CA  . ASP A 1 333 ? 177.54742 331.55529 20.85267  1.000 49.62477  ? 368 ASP F CA  1 
ATOM   2349 C C   . ASP A 1 333 ? 178.79610 332.11388 21.50732  1.000 48.15002  ? 368 ASP F C   1 
ATOM   2350 O O   . ASP A 1 333 ? 179.13332 333.27838 21.28402  1.000 45.53660  ? 368 ASP F O   1 
ATOM   2351 C CB  . ASP A 1 333 ? 177.67914 331.58794 19.32190  1.000 43.70519  ? 368 ASP F CB  1 
ATOM   2352 C CG  . ASP A 1 333 ? 178.60338 330.47811 18.78873  1.000 52.18106  ? 368 ASP F CG  1 
ATOM   2353 O OD1 . ASP A 1 333 ? 179.64606 330.22343 19.42878  1.000 48.01487  ? 368 ASP F OD1 1 
ATOM   2354 O OD2 . ASP A 1 333 ? 178.29312 329.81832 17.76955  1.000 62.69583  ? 368 ASP F OD2 1 
ATOM   2355 N N   . THR A 1 334 ? 179.53110 331.24779 22.22602  1.000 42.67938  ? 369 THR F N   1 
ATOM   2356 C CA  . THR A 1 334 ? 180.72506 331.68675 22.94250  1.000 46.61881  ? 369 THR F CA  1 
ATOM   2357 C C   . THR A 1 334 ? 181.84540 332.03087 21.99375  1.000 49.09363  ? 369 THR F C   1 
ATOM   2358 O O   . THR A 1 334 ? 182.83713 332.61417 22.42907  1.000 48.07154  ? 369 THR F O   1 
ATOM   2359 C CB  . THR A 1 334 ? 181.20446 330.60194 23.92540  1.000 49.82091  ? 369 THR F CB  1 
ATOM   2360 O OG1 . THR A 1 334 ? 181.58270 329.42086 23.20083  1.000 46.56304  ? 369 THR F OG1 1 
ATOM   2361 C CG2 . THR A 1 334 ? 180.08286 330.20923 24.91460  1.000 43.63431  ? 369 THR F CG2 1 
ATOM   2362 N N   . MET A 1 335 ? 181.65862 331.77572 20.69850  1.000 51.43769  ? 370 MET F N   1 
ATOM   2363 C CA  . MET A 1 335 ? 182.68085 332.11319 19.71493  1.000 54.98086  ? 370 MET F CA  1 
ATOM   2364 C C   . MET A 1 335 ? 182.96988 333.61297 19.72250  1.000 60.53472  ? 370 MET F C   1 
ATOM   2365 O O   . MET A 1 335 ? 184.13267 334.03298 19.62387  1.000 64.51643  ? 370 MET F O   1 
ATOM   2366 C CB  . MET A 1 335 ? 182.20921 331.67681 18.32266  1.000 55.44775  ? 370 MET F CB  1 
ATOM   2367 C CG  . MET A 1 335 ? 183.13172 332.05635 17.14739  1.000 72.65144  ? 370 MET F CG  1 
ATOM   2368 S SD  . MET A 1 335 ? 184.48588 330.86640 16.88536  1.000 82.49673  ? 370 MET F SD  1 
ATOM   2369 C CE  . MET A 1 335 ? 183.71731 329.36061 17.50101  1.000 67.07662  ? 370 MET F CE  1 
ATOM   2370 N N   . ASN A 1 336 ? 181.93851 334.44660 19.89593  1.000 54.85134  ? 371 ASN F N   1 
ATOM   2371 C CA  . ASN A 1 336 ? 182.26559 335.86828 19.87263  1.000 65.89569  ? 371 ASN F CA  1 
ATOM   2372 C C   . ASN A 1 336 ? 181.95386 336.49376 21.23152  1.000 59.33287  ? 371 ASN F C   1 
ATOM   2373 O O   . ASN A 1 336 ? 181.17372 337.44655 21.34076  1.000 57.65146  ? 371 ASN F O   1 
ATOM   2374 C CB  . ASN A 1 336 ? 181.45247 336.55217 18.76518  1.000 71.11728  ? 371 ASN F CB  1 
ATOM   2375 C CG  . ASN A 1 336 ? 182.27129 336.81881 17.49112  1.000 81.22703  ? 371 ASN F CG  1 
ATOM   2376 O OD1 . ASN A 1 336 ? 183.35391 337.42103 17.52091  1.000 77.79720  ? 371 ASN F OD1 1 
ATOM   2377 N ND2 . ASN A 1 336 ? 181.74150 336.36331 16.36260  1.000 75.77098  ? 371 ASN F ND2 1 
ATOM   2378 N N   . SER A 1 337 ? 182.67475 336.05987 22.25435  1.000 52.18229  ? 372 SER F N   1 
ATOM   2379 C CA  . SER A 1 337 ? 182.43065 336.54630 23.59476  1.000 42.77562  ? 372 SER F CA  1 
ATOM   2380 C C   . SER A 1 337 ? 183.77788 336.84273 24.20945  1.000 43.58282  ? 372 SER F C   1 
ATOM   2381 O O   . SER A 1 337 ? 184.82791 336.47270 23.68344  1.000 41.99698  ? 372 SER F O   1 
ATOM   2382 C CB  . SER A 1 337 ? 181.69364 335.54183 24.46927  1.000 48.54391  ? 372 SER F CB  1 
ATOM   2383 O OG  . SER A 1 337 ? 182.49018 334.36471 24.62245  1.000 50.33736  ? 372 SER F OG  1 
ATOM   2384 N N   . LEU A 1 338 ? 183.72989 337.56098 25.30524  1.000 40.56360  ? 373 LEU F N   1 
ATOM   2385 C CA  . LEU A 1 338 ? 184.89930 337.84558 26.10019  1.000 44.13743  ? 373 LEU F CA  1 
ATOM   2386 C C   . LEU A 1 338 ? 184.64445 337.20480 27.45310  1.000 41.98010  ? 373 LEU F C   1 
ATOM   2387 O O   . LEU A 1 338 ? 183.49352 337.07023 27.89607  1.000 37.14074  ? 373 LEU F O   1 
ATOM   2388 C CB  . LEU A 1 338 ? 185.14989 339.36933 26.23865  1.000 43.57829  ? 373 LEU F CB  1 
ATOM   2389 C CG  . LEU A 1 338 ? 185.33418 340.24277 24.97855  1.000 52.98545  ? 373 LEU F CG  1 
ATOM   2390 C CD1 . LEU A 1 338 ? 185.63223 341.70850 25.31948  1.000 47.57102  ? 373 LEU F CD1 1 
ATOM   2391 C CD2 . LEU A 1 338 ? 186.43228 339.69785 24.12065  1.000 46.34773  ? 373 LEU F CD2 1 
ATOM   2392 N N   . THR A 1 339 ? 185.71820 336.81157 28.10200  1.000 41.55846  ? 374 THR F N   1 
ATOM   2393 C CA  . THR A 1 339 ? 185.62292 336.10087 29.36430  1.000 43.85204  ? 374 THR F CA  1 
ATOM   2394 C C   . THR A 1 339 ? 186.06032 337.07548 30.43409  1.000 40.85959  ? 374 THR F C   1 
ATOM   2395 O O   . THR A 1 339 ? 187.20060 337.54248 30.42487  1.000 40.85398  ? 374 THR F O   1 
ATOM   2396 C CB  . THR A 1 339 ? 186.44957 334.81281 29.36423  1.000 44.47936  ? 374 THR F CB  1 
ATOM   2397 O OG1 . THR A 1 339 ? 186.01754 333.99178 28.27718  1.000 45.10885  ? 374 THR F OG1 1 
ATOM   2398 C CG2 . THR A 1 339 ? 186.23435 334.04566 30.66703  1.000 45.00705  ? 374 THR F CG2 1 
ATOM   2399 N N   . LEU A 1 340 ? 185.15881 337.37117 31.34705  1.000 38.21776  ? 375 LEU F N   1 
ATOM   2400 C CA  . LEU A 1 340 ? 185.45644 338.31841 32.38774  1.000 42.88672  ? 375 LEU F CA  1 
ATOM   2401 C C   . LEU A 1 340 ? 185.32463 337.69643 33.77690  1.000 43.26901  ? 375 LEU F C   1 
ATOM   2402 O O   . LEU A 1 340 ? 184.52075 336.77132 33.98405  1.000 39.00122  ? 375 LEU F O   1 
ATOM   2403 C CB  . LEU A 1 340 ? 184.47508 339.49659 32.26708  1.000 39.96214  ? 375 LEU F CB  1 
ATOM   2404 C CG  . LEU A 1 340 ? 184.42638 340.19966 30.90167  1.000 44.53048  ? 375 LEU F CG  1 
ATOM   2405 C CD1 . LEU A 1 340 ? 183.37696 341.32027 30.89162  1.000 37.64409  ? 375 LEU F CD1 1 
ATOM   2406 C CD2 . LEU A 1 340 ? 185.78885 340.74455 30.56727  1.000 41.41092  ? 375 LEU F CD2 1 
ATOM   2407 N N   . PRO A 1 341 ? 186.07055 338.20531 34.75620  1.000 41.96719  ? 376 PRO F N   1 
ATOM   2408 C CA  . PRO A 1 341 ? 185.87572 337.72434 36.13138  1.000 40.34721  ? 376 PRO F CA  1 
ATOM   2409 C C   . PRO A 1 341 ? 184.48229 338.09614 36.59691  1.000 46.34662  ? 376 PRO F C   1 
ATOM   2410 O O   . PRO A 1 341 ? 183.90964 339.09719 36.16374  1.000 46.48473  ? 376 PRO F O   1 
ATOM   2411 C CB  . PRO A 1 341 ? 186.96969 338.45732 36.93273  1.000 42.49758  ? 376 PRO F CB  1 
ATOM   2412 C CG  . PRO A 1 341 ? 187.30448 339.68367 36.09656  1.000 47.73807  ? 376 PRO F CG  1 
ATOM   2413 C CD  . PRO A 1 341 ? 187.13870 339.22398 34.65691  1.000 38.62836  ? 376 PRO F CD  1 
ATOM   2414 N N   . SER A 1 342 ? 183.92990 337.26860 37.48329  1.000 46.13694  ? 377 SER F N   1 
ATOM   2415 C CA  . SER A 1 342 ? 182.58167 337.50330 37.98122  1.000 47.81415  ? 377 SER F CA  1 
ATOM   2416 C C   . SER A 1 342 ? 182.47719 338.79853 38.76155  1.000 47.77650  ? 377 SER F C   1 
ATOM   2417 O O   . SER A 1 342 ? 181.36386 339.30069 38.95357  1.000 46.51473  ? 377 SER F O   1 
ATOM   2418 C CB  . SER A 1 342 ? 182.10074 336.30497 38.81505  1.000 49.04362  ? 377 SER F CB  1 
ATOM   2419 O OG  . SER A 1 342 ? 182.96780 336.10791 39.90948  1.000 59.72951  ? 377 SER F OG  1 
ATOM   2420 N N   . GLU A 1 343 ? 183.60109 339.40194 39.13544  1.000 49.42433  ? 378 GLU F N   1 
ATOM   2421 C CA  . GLU A 1 343 ? 183.51365 340.66871 39.85268  1.000 49.90067  ? 378 GLU F CA  1 
ATOM   2422 C C   . GLU A 1 343 ? 183.04756 341.79156 38.94388  1.000 50.99223  ? 378 GLU F C   1 
ATOM   2423 O O   . GLU A 1 343 ? 182.67790 342.85936 39.44745  1.000 48.06822  ? 378 GLU F O   1 
ATOM   2424 C CB  . GLU A 1 343 ? 184.86242 341.05734 40.46384  1.000 47.25456  ? 378 GLU F CB  1 
ATOM   2425 C CG  . GLU A 1 343 ? 185.28704 340.23129 41.67147  1.000 49.83017  ? 378 GLU F CG  1 
ATOM   2426 C CD  . GLU A 1 343 ? 185.58175 338.78224 41.31792  1.000 58.10340  ? 378 GLU F CD  1 
ATOM   2427 O OE1 . GLU A 1 343 ? 186.13826 338.49959 40.21320  1.000 54.10669  ? 378 GLU F OE1 1 
ATOM   2428 O OE2 . GLU A 1 343 ? 185.25462 337.92648 42.16401  1.000 59.07561  ? 378 GLU F OE2 1 
ATOM   2429 N N   . VAL A 1 344 ? 182.91346 341.52311 37.64227  1.000 46.01213  ? 379 VAL F N   1 
ATOM   2430 C CA  . VAL A 1 344 ? 182.48129 342.55650 36.72785  1.000 44.27919  ? 379 VAL F CA  1 
ATOM   2431 C C   . VAL A 1 344 ? 181.05676 342.97599 37.05241  1.000 43.21025  ? 379 VAL F C   1 
ATOM   2432 O O   . VAL A 1 344 ? 180.66841 344.10662 36.75915  1.000 41.90561  ? 379 VAL F O   1 
ATOM   2433 C CB  . VAL A 1 344 ? 182.59581 342.03971 35.28159  1.000 43.67737  ? 379 VAL F CB  1 
ATOM   2434 C CG1 . VAL A 1 344 ? 181.50042 341.02169 34.99780  1.000 39.95065  ? 379 VAL F CG1 1 
ATOM   2435 C CG2 . VAL A 1 344 ? 182.54564 343.18170 34.30453  1.000 48.75868  ? 379 VAL F CG2 1 
ATOM   2436 N N   . ASN A 1 345 ? 180.29337 342.12396 37.73164  1.000 42.48501  ? 380 ASN F N   1 
ATOM   2437 C CA  . ASN A 1 345 ? 178.93761 342.47988 38.11993  1.000 44.20673  ? 380 ASN F CA  1 
ATOM   2438 C C   . ASN A 1 345 ? 178.93214 343.52381 39.21852  1.000 49.46543  ? 380 ASN F C   1 
ATOM   2439 O O   . ASN A 1 345 ? 177.88964 344.13391 39.48413  1.000 49.34464  ? 380 ASN F O   1 
ATOM   2440 C CB  . ASN A 1 345 ? 178.13365 341.26403 38.59187  1.000 45.24604  ? 380 ASN F CB  1 
ATOM   2441 C CG  . ASN A 1 345 ? 176.67093 341.62624 38.94432  1.000 59.05733  ? 380 ASN F CG  1 
ATOM   2442 O OD1 . ASN A 1 345 ? 175.89912 342.13608 38.10634  1.000 56.37563  ? 380 ASN F OD1 1 
ATOM   2443 N ND2 . ASN A 1 345 ? 176.29096 341.36353 40.18671  1.000 55.10293  ? 380 ASN F ND2 1 
ATOM   2444 N N   . LEU A 1 346 ? 180.06092 343.75451 39.87260  1.000 47.21342  ? 381 LEU F N   1 
ATOM   2445 C CA  . LEU A 1 346 ? 179.97318 344.73377 40.93339  1.000 50.09585  ? 381 LEU F CA  1 
ATOM   2446 C C   . LEU A 1 346 ? 179.95270 346.16177 40.38391  1.000 55.16079  ? 381 LEU F C   1 
ATOM   2447 O O   . LEU A 1 346 ? 179.58951 347.09872 41.11459  1.000 49.70509  ? 381 LEU F O   1 
ATOM   2448 C CB  . LEU A 1 346 ? 181.22961 344.53398 41.77603  1.000 50.86461  ? 381 LEU F CB  1 
ATOM   2449 C CG  . LEU A 1 346 ? 181.24321 343.47974 42.88512  1.000 51.85754  ? 381 LEU F CG  1 
ATOM   2450 C CD1 . LEU A 1 346 ? 182.70075 343.36815 43.34177  1.000 50.25465  ? 381 LEU F CD1 1 
ATOM   2451 C CD2 . LEU A 1 346 ? 180.25554 343.69838 44.01729  1.000 51.38966  ? 381 LEU F CD2 1 
ATOM   2452 N N   . CYS A 1 347 ? 180.11624 346.32437 39.06968  1.000 46.25428  ? 382 CYS F N   1 
ATOM   2453 C CA  . CYS A 1 347 ? 179.96573 347.65055 38.51900  1.000 51.66101  ? 382 CYS F CA  1 
ATOM   2454 C C   . CYS A 1 347 ? 178.50639 348.02953 38.57374  1.000 49.07131  ? 382 CYS F C   1 
ATOM   2455 O O   . CYS A 1 347 ? 178.17721 349.18725 38.37728  1.000 49.54322  ? 382 CYS F O   1 
ATOM   2456 C CB  . CYS A 1 347 ? 180.45575 347.67451 37.07581  1.000 42.36957  ? 382 CYS F CB  1 
ATOM   2457 S SG  . CYS A 1 347 ? 182.20476 347.39167 37.02798  1.000 55.18652  ? 382 CYS F SG  1 
ATOM   2458 N N   . ASN A 1 348 ? 177.62895 347.03497 38.66855  1.000 44.08662  ? 383 ASN F N   1 
ATOM   2459 C CA  . ASN A 1 348 ? 176.21095 347.27394 38.81075  1.000 48.34347  ? 383 ASN F CA  1 
ATOM   2460 C C   . ASN A 1 348 ? 175.81195 347.58331 40.24622  1.000 51.44057  ? 383 ASN F C   1 
ATOM   2461 O O   . ASN A 1 348 ? 174.71171 348.09184 40.46760  1.000 60.43529  ? 383 ASN F O   1 
ATOM   2462 C CB  . ASN A 1 348 ? 175.35740 346.17913 38.16879  1.000 41.95246  ? 383 ASN F CB  1 
ATOM   2463 C CG  . ASN A 1 348 ? 175.81584 345.90806 36.77408  1.000 46.80772  ? 383 ASN F CG  1 
ATOM   2464 O OD1 . ASN A 1 348 ? 175.69680 346.78239 35.90520  1.000 43.41163  ? 383 ASN F OD1 1 
ATOM   2465 N ND2 . ASN A 1 348 ? 176.10925 344.66222 36.48951  1.000 39.87749  ? 383 ASN F ND2 1 
ATOM   2466 N N   . VAL A 1 349 ? 176.57763 347.17143 41.25022  1.000 52.92999  ? 384 VAL F N   1 
ATOM   2467 C CA  . VAL A 1 349 ? 176.16678 347.47618 42.60338  1.000 53.87134  ? 384 VAL F CA  1 
ATOM   2468 C C   . VAL A 1 349 ? 176.98756 348.58671 43.24868  1.000 53.46087  ? 384 VAL F C   1 
ATOM   2469 O O   . VAL A 1 349 ? 176.41501 349.42069 43.95467  1.000 55.81815  ? 384 VAL F O   1 
ATOM   2470 C CB  . VAL A 1 349 ? 176.30935 346.16638 43.41542  1.000 62.01453  ? 384 VAL F CB  1 
ATOM   2471 C CG1 . VAL A 1 349 ? 176.36801 346.43498 44.92248  1.000 62.12711  ? 384 VAL F CG1 1 
ATOM   2472 C CG2 . VAL A 1 349 ? 175.22077 345.16704 43.05942  1.000 64.46158  ? 384 VAL F CG2 1 
ATOM   2473 N N   . ASP A 1 350 ? 178.27169 348.69358 42.93658  1.000 51.89153  ? 385 ASP F N   1 
ATOM   2474 C CA  . ASP A 1 350 ? 179.16150 349.72238 43.48087  1.000 54.50602  ? 385 ASP F CA  1 
ATOM   2475 C C   . ASP A 1 350 ? 180.19000 350.06736 42.40359  1.000 49.15119  ? 385 ASP F C   1 
ATOM   2476 O O   . ASP A 1 350 ? 181.20546 349.37954 42.30979  1.000 51.17151  ? 385 ASP F O   1 
ATOM   2477 C CB  . ASP A 1 350 ? 179.80680 349.34971 44.80160  1.000 59.61815  ? 385 ASP F CB  1 
ATOM   2478 C CG  . ASP A 1 350 ? 180.65970 350.48633 45.34004  1.000 62.83039  ? 385 ASP F CG  1 
ATOM   2479 O OD1 . ASP A 1 350 ? 180.43027 351.64770 44.90080  1.000 64.53677  ? 385 ASP F OD1 1 
ATOM   2480 O OD2 . ASP A 1 350 ? 181.50190 350.24422 46.23247  1.000 74.74241  ? 385 ASP F OD2 1 
ATOM   2481 N N   . ILE A 1 351 ? 180.04222 351.17269 41.69230  1.000 51.00405  ? 386 ILE F N   1 
ATOM   2482 C CA  . ILE A 1 351 ? 180.97472 351.34687 40.58446  1.000 50.13424  ? 386 ILE F CA  1 
ATOM   2483 C C   . ILE A 1 351 ? 182.32761 351.82237 41.09438  1.000 53.10095  ? 386 ILE F C   1 
ATOM   2484 O O   . ILE A 1 351 ? 183.30865 351.78471 40.33960  1.000 51.55862  ? 386 ILE F O   1 
ATOM   2485 C CB  . ILE A 1 351 ? 180.36413 352.28360 39.53059  1.000 48.22964  ? 386 ILE F CB  1 
ATOM   2486 C CG1 . ILE A 1 351 ? 181.19380 352.22061 38.24227  1.000 49.64644  ? 386 ILE F CG1 1 
ATOM   2487 C CG2 . ILE A 1 351 ? 180.29676 353.69797 40.07436  1.000 49.78369  ? 386 ILE F CG2 1 
ATOM   2488 C CD1 . ILE A 1 351 ? 180.65768 353.01754 37.10091  1.000 48.37677  ? 386 ILE F CD1 1 
ATOM   2489 N N   . PHE A 1 352 ? 182.37759 352.39020 42.29342  1.000 58.32233  ? 387 PHE F N   1 
ATOM   2490 C CA  . PHE A 1 352 ? 183.57504 352.88060 42.98048  1.000 58.40796  ? 387 PHE F CA  1 
ATOM   2491 C C   . PHE A 1 352 ? 184.25744 351.76047 43.77951  1.000 59.62632  ? 387 PHE F C   1 
ATOM   2492 O O   . PHE A 1 352 ? 185.27479 352.00686 44.42312  1.000 74.10089  ? 387 PHE F O   1 
ATOM   2493 C CB  . PHE A 1 352 ? 183.22383 354.05817 43.89226  1.000 51.07298  ? 387 PHE F CB  1 
ATOM   2494 C CG  . PHE A 1 352 ? 182.96079 355.31801 43.14475  1.000 51.49934  ? 387 PHE F CG  1 
ATOM   2495 C CD1 . PHE A 1 352 ? 183.83227 355.70418 42.13724  1.000 49.90352  ? 387 PHE F CD1 1 
ATOM   2496 C CD2 . PHE A 1 352 ? 181.78696 356.03300 43.33633  1.000 45.95471  ? 387 PHE F CD2 1 
ATOM   2497 C CE1 . PHE A 1 352 ? 183.60292 356.85251 41.40853  1.000 57.40094  ? 387 PHE F CE1 1 
ATOM   2498 C CE2 . PHE A 1 352 ? 181.53451 357.16854 42.59983  1.000 51.88280  ? 387 PHE F CE2 1 
ATOM   2499 C CZ  . PHE A 1 352 ? 182.45455 357.58502 41.63018  1.000 53.83108  ? 387 PHE F CZ  1 
ATOM   2500 N N   . ASN A 1 353 ? 183.85817 350.52622 43.57287  1.000 60.75788  ? 388 ASN F N   1 
ATOM   2501 C CA  . ASN A 1 353 ? 184.28474 349.33805 44.32129  1.000 62.29508  ? 388 ASN F CA  1 
ATOM   2502 C C   . ASN A 1 353 ? 185.61044 348.77525 43.82489  1.000 65.18825  ? 388 ASN F C   1 
ATOM   2503 O O   . ASN A 1 353 ? 185.81706 348.65789 42.61985  1.000 66.83564  ? 388 ASN F O   1 
ATOM   2504 C CB  . ASN A 1 353 ? 183.22832 348.28172 44.24311  1.000 60.24630  ? 388 ASN F CB  1 
ATOM   2505 C CG  . ASN A 1 353 ? 183.80512 346.91579 44.40688  1.000 76.58919  ? 388 ASN F CG  1 
ATOM   2506 O OD1 . ASN A 1 353 ? 184.16677 346.27525 43.40091  1.000 72.43655  ? 388 ASN F OD1 1 
ATOM   2507 N ND2 . ASN A 1 353 ? 183.94599 346.45645 45.66773  1.000 80.13329  ? 388 ASN F ND2 1 
ATOM   2508 N N   . PRO A 1 354 ? 186.59438 348.60767 44.71897  1.000 70.43276  ? 389 PRO F N   1 
ATOM   2509 C CA  . PRO A 1 354 ? 187.91376 348.11970 44.29083  1.000 66.27269  ? 389 PRO F CA  1 
ATOM   2510 C C   . PRO A 1 354 ? 188.03727 346.67951 43.81619  1.000 69.06197  ? 389 PRO F C   1 
ATOM   2511 O O   . PRO A 1 354 ? 189.10767 346.36811 43.28138  1.000 70.47238  ? 389 PRO F O   1 
ATOM   2512 C CB  . PRO A 1 354 ? 188.72761 348.19659 45.58655  1.000 71.18187  ? 389 PRO F CB  1 
ATOM   2513 C CG  . PRO A 1 354 ? 187.95814 349.02941 46.53012  1.000 80.43735  ? 389 PRO F CG  1 
ATOM   2514 C CD  . PRO A 1 354 ? 186.51657 348.78816 46.17680  1.000 73.34268  ? 389 PRO F CD  1 
ATOM   2515 N N   . LYS A 1 355 ? 187.07426 345.76343 43.96426  1.000 69.13757  ? 390 LYS F N   1 
ATOM   2516 C CA  . LYS A 1 355 ? 187.46844 344.46642 43.42932  1.000 58.55325  ? 390 LYS F CA  1 
ATOM   2517 C C   . LYS A 1 355 ? 187.53574 344.47691 41.90971  1.000 62.74387  ? 390 LYS F C   1 
ATOM   2518 O O   . LYS A 1 355 ? 188.32896 343.73337 41.31786  1.000 60.88756  ? 390 LYS F O   1 
ATOM   2519 C CB  . LYS A 1 355 ? 186.53692 343.35922 43.90426  1.000 55.89123  ? 390 LYS F CB  1 
ATOM   2520 C CG  . LYS A 1 355 ? 186.60271 343.06329 45.40190  1.000 64.47251  ? 390 LYS F CG  1 
ATOM   2521 C CD  . LYS A 1 355 ? 185.62648 341.93236 45.73894  1.000 66.78550  ? 390 LYS F CD  1 
ATOM   2522 C CE  . LYS A 1 355 ? 185.61409 341.56013 47.21094  1.000 70.75823  ? 390 LYS F CE  1 
ATOM   2523 N NZ  . LYS A 1 355 ? 184.43098 342.17952 47.88925  1.000 77.09731  ? 390 LYS F NZ  1 
ATOM   2524 N N   . TYR A 1 356 ? 186.75844 345.34116 41.25817  1.000 62.96536  ? 391 TYR F N   1 
ATOM   2525 C CA  . TYR A 1 356 ? 186.81043 345.43833 39.80817  1.000 52.52118  ? 391 TYR F CA  1 
ATOM   2526 C C   . TYR A 1 356 ? 186.87983 346.89265 39.34560  1.000 54.23591  ? 391 TYR F C   1 
ATOM   2527 O O   . TYR A 1 356 ? 186.12887 347.74884 39.82524  1.000 58.79256  ? 391 TYR F O   1 
ATOM   2528 C CB  . TYR A 1 356 ? 185.62353 344.67788 39.18579  1.000 48.34940  ? 391 TYR F CB  1 
ATOM   2529 C CG  . TYR A 1 356 ? 185.67216 344.53472 37.66491  1.000 53.31182  ? 391 TYR F CG  1 
ATOM   2530 C CD1 . TYR A 1 356 ? 185.24099 345.56468 36.84321  1.000 52.31670  ? 391 TYR F CD1 1 
ATOM   2531 C CD2 . TYR A 1 356 ? 186.17648 343.39553 37.05368  1.000 52.66456  ? 391 TYR F CD2 1 
ATOM   2532 C CE1 . TYR A 1 356 ? 185.28686 345.46939 35.46870  1.000 55.23710  ? 391 TYR F CE1 1 
ATOM   2533 C CE2 . TYR A 1 356 ? 186.22905 343.28843 35.63240  1.000 52.13343  ? 391 TYR F CE2 1 
ATOM   2534 C CZ  . TYR A 1 356 ? 185.77304 344.33203 34.85638  1.000 55.58682  ? 391 TYR F CZ  1 
ATOM   2535 O OH  . TYR A 1 356 ? 185.79407 344.30413 33.45950  1.000 55.89269  ? 391 TYR F OH  1 
ATOM   2536 N N   . ASP A 1 357 ? 187.78395 347.16038 38.42942  1.000 51.11605  ? 392 ASP F N   1 
ATOM   2537 C CA  . ASP A 1 357 ? 188.06312 348.46471 37.82973  1.000 58.29336  ? 392 ASP F CA  1 
ATOM   2538 C C   . ASP A 1 357 ? 186.94226 348.72336 36.82140  1.000 53.19310  ? 392 ASP F C   1 
ATOM   2539 O O   . ASP A 1 357 ? 187.13785 348.55471 35.62129  1.000 51.89282  ? 392 ASP F O   1 
ATOM   2540 C CB  . ASP A 1 357 ? 189.44638 348.54193 37.22854  1.000 60.32184  ? 392 ASP F CB  1 
ATOM   2541 C CG  . ASP A 1 357 ? 189.85479 349.96493 37.03493  1.000 68.89740  ? 392 ASP F CG  1 
ATOM   2542 O OD1 . ASP A 1 357 ? 189.22886 350.83174 37.71161  1.000 66.57894  ? 392 ASP F OD1 1 
ATOM   2543 O OD2 . ASP A 1 357 ? 190.77729 350.21178 36.22981  1.000 71.70466  ? 392 ASP F OD2 1 
ATOM   2544 N N   . CYS A 1 358 ? 185.82816 349.31655 37.25368  1.000 55.07725  ? 393 CYS F N   1 
ATOM   2545 C CA  . CYS A 1 358 ? 184.75039 349.56352 36.29846  1.000 53.05957  ? 393 CYS F CA  1 
ATOM   2546 C C   . CYS A 1 358 ? 185.07157 350.63137 35.28750  1.000 48.88211  ? 393 CYS F C   1 
ATOM   2547 O O   . CYS A 1 358 ? 185.76299 351.60616 35.56147  1.000 56.44070  ? 393 CYS F O   1 
ATOM   2548 C CB  . CYS A 1 358 ? 183.49369 350.00404 37.04508  1.000 48.58206  ? 393 CYS F CB  1 
ATOM   2549 S SG  . CYS A 1 358 ? 182.97129 348.83658 38.30367  1.000 53.18157  ? 393 CYS F SG  1 
ATOM   2550 N N   . LYS A 1 359 ? 184.67964 350.31937 34.05765  1.000 48.35015  ? 394 LYS F N   1 
ATOM   2551 C CA  . LYS A 1 359 ? 185.07756 351.08644 32.90441  1.000 55.99694  ? 394 LYS F CA  1 
ATOM   2552 C C   . LYS A 1 359 ? 184.06921 352.17340 32.53877  1.000 52.88994  ? 394 LYS F C   1 
ATOM   2553 O O   . LYS A 1 359 ? 182.84808 351.99404 32.65554  1.000 50.53601  ? 394 LYS F O   1 
ATOM   2554 C CB  . LYS A 1 359 ? 185.15574 350.06804 31.75580  1.000 61.54083  ? 394 LYS F CB  1 
ATOM   2555 C CG  . LYS A 1 359 ? 186.19402 348.92718 32.02334  1.000 64.59941  ? 394 LYS F CG  1 
ATOM   2556 C CD  . LYS A 1 359 ? 187.45517 349.01110 31.19096  1.000 73.16092  ? 394 LYS F CD  1 
ATOM   2557 C CE  . LYS A 1 359 ? 187.13202 348.83779 29.70419  1.000 77.90058  ? 394 LYS F CE  1 
ATOM   2558 N NZ  . LYS A 1 359 ? 186.46653 347.53818 29.35035  1.000 76.19902  ? 394 LYS F NZ  1 
ATOM   2559 N N   . ILE A 1 360 ? 184.58821 353.31265 32.10962  1.000 48.14070  ? 395 ILE F N   1 
ATOM   2560 C CA  . ILE A 1 360 ? 183.76649 354.42206 31.66781  1.000 49.00025  ? 395 ILE F CA  1 
ATOM   2561 C C   . ILE A 1 360 ? 184.42473 355.07617 30.46007  1.000 51.89846  ? 395 ILE F C   1 
ATOM   2562 O O   . ILE A 1 360 ? 185.61591 354.92330 30.21157  1.000 45.20067  ? 395 ILE F O   1 
ATOM   2563 C CB  . ILE A 1 360 ? 183.50797 355.42081 32.79197  1.000 49.14296  ? 395 ILE F CB  1 
ATOM   2564 C CG1 . ILE A 1 360 ? 184.82703 356.04655 33.23432  1.000 50.55185  ? 395 ILE F CG1 1 
ATOM   2565 C CG2 . ILE A 1 360 ? 182.76782 354.71355 33.92034  1.000 46.64077  ? 395 ILE F CG2 1 
ATOM   2566 C CD1 . ILE A 1 360 ? 184.62038 357.27522 34.04165  1.000 51.18042  ? 395 ILE F CD1 1 
ATOM   2567 N N   . MET A 1 361 ? 183.66542 355.91199 29.78921  1.000 48.77575  ? 396 MET F N   1 
ATOM   2568 C CA  . MET A 1 361 ? 184.19034 356.80119 28.77521  1.000 50.33898  ? 396 MET F CA  1 
ATOM   2569 C C   . MET A 1 361 ? 183.69448 358.19776 29.11294  1.000 46.79456  ? 396 MET F C   1 
ATOM   2570 O O   . MET A 1 361 ? 182.63551 358.35614 29.72150  1.000 45.96078  ? 396 MET F O   1 
ATOM   2571 C CB  . MET A 1 361 ? 183.79872 356.39913 27.36887  1.000 46.69679  ? 396 MET F CB  1 
ATOM   2572 C CG  . MET A 1 361 ? 182.33582 356.37366 27.17797  1.000 54.55886  ? 396 MET F CG  1 
ATOM   2573 S SD  . MET A 1 361 ? 181.87913 357.18848 25.65732  1.000 83.48965  ? 396 MET F SD  1 
ATOM   2574 C CE  . MET A 1 361 ? 182.47369 358.86176 25.94561  1.000 63.03851  ? 396 MET F CE  1 
ATOM   2575 N N   . THR A 1 362 ? 184.51093 359.19323 28.80492  1.000 43.43451  ? 397 THR F N   1 
ATOM   2576 C CA  . THR A 1 362 ? 184.22958 360.57947 29.13258  1.000 49.40686  ? 397 THR F CA  1 
ATOM   2577 C C   . THR A 1 362 ? 184.21670 361.42746 27.86654  1.000 52.79915  ? 397 THR F C   1 
ATOM   2578 O O   . THR A 1 362 ? 184.71965 361.03413 26.80990  1.000 57.77394  ? 397 THR F O   1 
ATOM   2579 C CB  . THR A 1 362 ? 185.26311 361.14844 30.07379  1.000 46.31356  ? 397 THR F CB  1 
ATOM   2580 O OG1 . THR A 1 362 ? 186.53011 361.09160 29.41569  1.000 49.79407  ? 397 THR F OG1 1 
ATOM   2581 C CG2 . THR A 1 362 ? 185.32608 360.29908 31.34537  1.000 48.00050  ? 397 THR F CG2 1 
ATOM   2582 N N   . SER A 1 363 ? 183.52962 362.54467 27.95809  1.000 53.86501  ? 398 SER F N   1 
ATOM   2583 C CA  . SER A 1 363 ? 183.45020 363.51908 26.87790  1.000 56.60535  ? 398 SER F CA  1 
ATOM   2584 C C   . SER A 1 363 ? 182.82071 364.78765 27.44321  1.000 58.52191  ? 398 SER F C   1 
ATOM   2585 O O   . SER A 1 363 ? 182.59280 364.91129 28.65358  1.000 58.07203  ? 398 SER F O   1 
ATOM   2586 C CB  . SER A 1 363 ? 182.60946 362.98132 25.73935  1.000 57.78171  ? 398 SER F CB  1 
ATOM   2587 O OG  . SER A 1 363 ? 181.27492 362.98668 26.18592  1.000 57.32079  ? 398 SER F OG  1 
ATOM   2588 N N   . LYS A 1 364 ? 182.60101 365.75675 26.56281  1.000 59.05787  ? 399 LYS F N   1 
ATOM   2589 C CA  . LYS A 1 364 ? 181.83413 366.94586 26.90576  1.000 59.91709  ? 399 LYS F CA  1 
ATOM   2590 C C   . LYS A 1 364 ? 180.66882 367.04328 25.91548  1.000 61.56284  ? 399 LYS F C   1 
ATOM   2591 O O   . LYS A 1 364 ? 180.15305 368.13152 25.64795  1.000 63.07989  ? 399 LYS F O   1 
ATOM   2592 C CB  . LYS A 1 364 ? 182.68150 368.22393 26.92178  1.000 58.56467  ? 399 LYS F CB  1 
ATOM   2593 C CG  . LYS A 1 364 ? 183.80340 368.19646 27.97258  1.000 60.33080  ? 399 LYS F CG  1 
ATOM   2594 C CD  . LYS A 1 364 ? 184.80383 369.37858 27.93900  1.000 66.72610  ? 399 LYS F CD  1 
ATOM   2595 C CE  . LYS A 1 364 ? 184.14837 370.72066 28.34871  1.000 69.43148  ? 399 LYS F CE  1 
ATOM   2596 N NZ  . LYS A 1 364 ? 183.66755 371.57213 27.21483  1.000 79.18025  ? 399 LYS F NZ  1 
ATOM   2597 N N   . THR A 1 365 ? 180.20997 365.88753 25.39482  1.000 57.43654  ? 400 THR F N   1 
ATOM   2598 C CA  . THR A 1 365 ? 179.18142 365.86973 24.35925  1.000 66.12499  ? 400 THR F CA  1 
ATOM   2599 C C   . THR A 1 365 ? 177.83346 365.48483 24.97128  1.000 61.56130  ? 400 THR F C   1 
ATOM   2600 O O   . THR A 1 365 ? 177.45968 364.31062 25.04419  1.000 63.14249  ? 400 THR F O   1 
ATOM   2601 C CB  . THR A 1 365 ? 179.61546 364.92421 23.24941  1.000 70.26867  ? 400 THR F CB  1 
ATOM   2602 O OG1 . THR A 1 365 ? 180.91707 365.32555 22.79285  1.000 79.15091  ? 400 THR F OG1 1 
ATOM   2603 C CG2 . THR A 1 365 ? 178.61398 364.95245 22.07006  1.000 71.43523  ? 400 THR F CG2 1 
ATOM   2604 N N   . ASP A 1 366 ? 177.07582 366.51098 25.36313  1.000 53.74919  ? 401 ASP F N   1 
ATOM   2605 C CA  . ASP A 1 366 ? 175.76733 366.33876 25.99485  1.000 62.61741  ? 401 ASP F CA  1 
ATOM   2606 C C   . ASP A 1 366 ? 174.65805 366.46654 24.94920  1.000 61.09236  ? 401 ASP F C   1 
ATOM   2607 O O   . ASP A 1 366 ? 173.98497 367.48788 24.82580  1.000 70.76516  ? 401 ASP F O   1 
ATOM   2608 C CB  . ASP A 1 366 ? 175.56714 367.29938 27.18621  1.000 64.38631  ? 401 ASP F CB  1 
ATOM   2609 C CG  . ASP A 1 366 ? 175.85108 368.77737 26.85518  1.000 76.01599  ? 401 ASP F CG  1 
ATOM   2610 O OD1 . ASP A 1 366 ? 176.63789 369.05926 25.91566  1.000 73.17668  ? 401 ASP F OD1 1 
ATOM   2611 O OD2 . ASP A 1 366 ? 175.28797 369.64898 27.56876  1.000 67.17614  ? 401 ASP F OD2 1 
ATOM   2612 N N   . VAL A 1 367 ? 174.44494 365.39611 24.20714  1.000 57.89445  ? 402 VAL F N   1 
ATOM   2613 C CA  . VAL A 1 367 ? 173.36668 365.33023 23.23087  1.000 54.13718  ? 402 VAL F CA  1 
ATOM   2614 C C   . VAL A 1 367 ? 172.35317 364.37632 23.85020  1.000 44.65506  ? 402 VAL F C   1 
ATOM   2615 O O   . VAL A 1 367 ? 172.73303 363.44499 24.56294  1.000 46.10878  ? 402 VAL F O   1 
ATOM   2616 C CB  . VAL A 1 367 ? 173.83767 364.86586 21.83658  1.000 57.31025  ? 402 VAL F CB  1 
ATOM   2617 C CG1 . VAL A 1 367 ? 174.67890 363.58932 21.95204  1.000 60.02242  ? 402 VAL F CG1 1 
ATOM   2618 C CG2 . VAL A 1 367 ? 172.64895 364.70464 20.86076  1.000 46.31505  ? 402 VAL F CG2 1 
ATOM   2619 N N   . SER A 1 368 ? 171.08377 364.73104 23.75274  1.000 45.14803  ? 403 SER F N   1 
ATOM   2620 C CA  . SER A 1 368 ? 170.02899 363.94554 24.37248  1.000 46.45694  ? 403 SER F CA  1 
ATOM   2621 C C   . SER A 1 368 ? 169.84121 362.61880 23.64662  1.000 43.77076  ? 403 SER F C   1 
ATOM   2622 O O   . SER A 1 368 ? 169.98299 362.53671 22.42554  1.000 44.99262  ? 403 SER F O   1 
ATOM   2623 C CB  . SER A 1 368 ? 168.70825 364.73883 24.30597  1.000 38.95993  ? 403 SER F CB  1 
ATOM   2624 O OG  . SER A 1 368 ? 168.79406 365.93862 25.07118  1.000 47.13690  ? 403 SER F OG  1 
ATOM   2625 N N   . SER A 1 369 ? 169.45563 361.58837 24.40237  1.000 41.31958  ? 404 SER F N   1 
ATOM   2626 C CA  . SER A 1 369 ? 169.20579 360.27766 23.81611  1.000 44.71354  ? 404 SER F CA  1 
ATOM   2627 C C   . SER A 1 369 ? 168.38249 359.44339 24.78036  1.000 37.01051  ? 404 SER F C   1 
ATOM   2628 O O   . SER A 1 369 ? 168.31272 359.71171 25.97861  1.000 43.20618  ? 404 SER F O   1 
ATOM   2629 C CB  . SER A 1 369 ? 170.50789 359.55809 23.39964  1.000 44.83531  ? 404 SER F CB  1 
ATOM   2630 O OG  . SER A 1 369 ? 171.38073 359.35399 24.49959  1.000 49.90457  ? 404 SER F OG  1 
ATOM   2631 N N   . SER A 1 370 ? 167.90987 358.32774 24.26312  1.000 43.90827  ? 405 SER F N   1 
ATOM   2632 C CA  . SER A 1 370 ? 167.14240 357.36199 25.01097  1.000 38.60978  ? 405 SER F CA  1 
ATOM   2633 C C   . SER A 1 370 ? 167.55487 355.94821 24.61540  1.000 43.45998  ? 405 SER F C   1 
ATOM   2634 O O   . SER A 1 370 ? 168.07141 355.70734 23.51668  1.000 39.97151  ? 405 SER F O   1 
ATOM   2635 C CB  . SER A 1 370 ? 165.66419 357.52744 24.72694  1.000 42.01654  ? 405 SER F CB  1 
ATOM   2636 O OG  . SER A 1 370 ? 164.92949 356.56293 25.48806  1.000 49.57419  ? 405 SER F OG  1 
ATOM   2637 N N   . VAL A 1 371 ? 167.38168 355.03261 25.55987  1.000 36.85950  ? 406 VAL F N   1 
ATOM   2638 C CA  . VAL A 1 371 ? 167.67282 353.62004 25.37383  1.000 41.25560  ? 406 VAL F CA  1 
ATOM   2639 C C   . VAL A 1 371 ? 166.45062 352.83922 25.81190  1.000 37.63412  ? 406 VAL F C   1 
ATOM   2640 O O   . VAL A 1 371 ? 166.06316 352.91639 26.97993  1.000 35.68976  ? 406 VAL F O   1 
ATOM   2641 C CB  . VAL A 1 371 ? 168.88677 353.16398 26.20857  1.000 40.13088  ? 406 VAL F CB  1 
ATOM   2642 C CG1 . VAL A 1 371 ? 169.10533 351.68281 26.02940  1.000 40.76047  ? 406 VAL F CG1 1 
ATOM   2643 C CG2 . VAL A 1 371 ? 170.15299 353.91388 25.81215  1.000 41.36644  ? 406 VAL F CG2 1 
ATOM   2644 N N   . ILE A 1 372 ? 165.88414 352.05110 24.90389  1.000 33.45417  ? 407 ILE F N   1 
ATOM   2645 C CA  . ILE A 1 372 ? 164.76499 351.17491 25.23391  1.000 37.01834  ? 407 ILE F CA  1 
ATOM   2646 C C   . ILE A 1 372 ? 165.31092 349.90300 25.88126  1.000 38.95329  ? 407 ILE F C   1 
ATOM   2647 O O   . ILE A 1 372 ? 166.07399 349.16448 25.25874  1.000 48.85996  ? 407 ILE F O   1 
ATOM   2648 C CB  . ILE A 1 372 ? 163.94818 350.83647 23.98543  1.000 42.10868  ? 407 ILE F CB  1 
ATOM   2649 C CG1 . ILE A 1 372 ? 163.34397 352.13800 23.41605  1.000 42.57067  ? 407 ILE F CG1 1 
ATOM   2650 C CG2 . ILE A 1 372 ? 162.92464 349.74812 24.33824  1.000 38.11346  ? 407 ILE F CG2 1 
ATOM   2651 C CD1 . ILE A 1 372 ? 162.44645 352.90247 24.39669  1.000 36.10631  ? 407 ILE F CD1 1 
ATOM   2652 N N   . THR A 1 373 ? 164.96515 349.66303 27.14277  1.000 41.54120  ? 408 THR F N   1 
ATOM   2653 C CA  . THR A 1 373 ? 165.42141 348.49343 27.89716  1.000 41.15505  ? 408 THR F CA  1 
ATOM   2654 C C   . THR A 1 373 ? 164.40240 347.35056 27.80461  1.000 43.37714  ? 408 THR F C   1 
ATOM   2655 O O   . THR A 1 373 ? 163.51693 347.33715 26.94475  1.000 43.77574  ? 408 THR F O   1 
ATOM   2656 C CB  . THR A 1 373 ? 165.65749 348.88603 29.35209  1.000 39.37061  ? 408 THR F CB  1 
ATOM   2657 O OG1 . THR A 1 373 ? 164.37645 349.16805 29.92369  1.000 40.62356  ? 408 THR F OG1 1 
ATOM   2658 C CG2 . THR A 1 373 ? 166.51137 350.14409 29.44489  1.000 40.39811  ? 408 THR F CG2 1 
ATOM   2659 N N   . SER A 1 374 ? 164.56350 346.31646 28.63615  1.000 38.93401  ? 409 SER F N   1 
ATOM   2660 C CA  . SER A 1 374 ? 163.61129 345.21959 28.56188  1.000 41.67361  ? 409 SER F CA  1 
ATOM   2661 C C   . SER A 1 374 ? 162.27449 345.60376 29.19461  1.000 43.24737  ? 409 SER F C   1 
ATOM   2662 O O   . SER A 1 374 ? 161.21768 345.18113 28.71220  1.000 47.93777  ? 409 SER F O   1 
ATOM   2663 C CB  . SER A 1 374 ? 164.13608 343.94795 29.26488  1.000 43.95545  ? 409 SER F CB  1 
ATOM   2664 O OG  . SER A 1 374 ? 165.41510 343.51305 28.82695  1.000 46.51986  ? 409 SER F OG  1 
ATOM   2665 N N   . LEU A 1 375 ? 162.29007 346.43006 30.24374  1.000 44.63265  ? 410 LEU F N   1 
ATOM   2666 C CA  . LEU A 1 375 ? 161.06486 346.76768 30.96409  1.000 46.23812  ? 410 LEU F CA  1 
ATOM   2667 C C   . LEU A 1 375 ? 160.81833 348.26142 31.12273  1.000 44.62096  ? 410 LEU F C   1 
ATOM   2668 O O   . LEU A 1 375 ? 160.01860 348.64610 31.97906  1.000 49.04539  ? 410 LEU F O   1 
ATOM   2669 C CB  . LEU A 1 375 ? 161.07555 346.11473 32.35044  1.000 41.30942  ? 410 LEU F CB  1 
ATOM   2670 C CG  . LEU A 1 375 ? 161.14541 344.57804 32.36148  1.000 45.10850  ? 410 LEU F CG  1 
ATOM   2671 C CD1 . LEU A 1 375 ? 161.24716 344.04425 33.80000  1.000 45.34145  ? 410 LEU F CD1 1 
ATOM   2672 C CD2 . LEU A 1 375 ? 159.96827 343.95501 31.64467  1.000 50.96133  ? 410 LEU F CD2 1 
ATOM   2673 N N   . GLY A 1 376 ? 161.49077 349.10995 30.34879  1.000 40.90657  ? 411 GLY F N   1 
ATOM   2674 C CA  . GLY A 1 376 ? 161.30392 350.53861 30.47127  1.000 37.06594  ? 411 GLY F CA  1 
ATOM   2675 C C   . GLY A 1 376 ? 162.18621 351.31995 29.52653  1.000 38.17446  ? 411 GLY F C   1 
ATOM   2676 O O   . GLY A 1 376 ? 162.43745 350.87591 28.41083  1.000 37.06068  ? 411 GLY F O   1 
ATOM   2677 N N   . ALA A 1 377 ? 162.66937 352.48651 29.94724  1.000 34.47462  ? 412 ALA F N   1 
ATOM   2678 C CA  . ALA A 1 377 ? 163.47576 353.29182 29.04888  1.000 37.60781  ? 412 ALA F CA  1 
ATOM   2679 C C   . ALA A 1 377 ? 164.33233 354.24175 29.85400  1.000 38.31838  ? 412 ALA F C   1 
ATOM   2680 O O   . ALA A 1 377 ? 163.84822 354.82103 30.82421  1.000 38.26866  ? 412 ALA F O   1 
ATOM   2681 C CB  . ALA A 1 377 ? 162.60212 354.07584 28.07227  1.000 35.67762  ? 412 ALA F CB  1 
ATOM   2682 N N   . ILE A 1 378 ? 165.61501 354.31228 29.52061  1.000 33.68892  ? 413 ILE F N   1 
ATOM   2683 C CA  . ILE A 1 378 ? 166.48235 355.33431 30.07265  1.000 36.42607  ? 413 ILE F CA  1 
ATOM   2684 C C   . ILE A 1 378 ? 166.42500 356.52472 29.15299  1.000 34.79810  ? 413 ILE F C   1 
ATOM   2685 O O   . ILE A 1 378 ? 166.43961 356.37831 27.92375  1.000 36.88096  ? 413 ILE F O   1 
ATOM   2686 C CB  . ILE A 1 378 ? 167.92778 354.84623 30.22250  1.000 34.54404  ? 413 ILE F CB  1 
ATOM   2687 C CG1 . ILE A 1 378 ? 167.97653 353.52269 30.98490  1.000 38.24399  ? 413 ILE F CG1 1 
ATOM   2688 C CG2 . ILE A 1 378 ? 168.83205 355.96809 30.77204  1.000 33.95313  ? 413 ILE F CG2 1 
ATOM   2689 C CD1 . ILE A 1 378 ? 169.39368 352.94875 31.06946  1.000 34.82218  ? 413 ILE F CD1 1 
ATOM   2690 N N   . VAL A 1 379 ? 166.33594 357.70976 29.73986  1.000 33.80550  ? 414 VAL F N   1 
ATOM   2691 C CA  . VAL A 1 379 ? 166.26517 358.93647 28.95853  1.000 33.64144  ? 414 VAL F CA  1 
ATOM   2692 C C   . VAL A 1 379 ? 167.35395 359.83435 29.49473  1.000 36.43211  ? 414 VAL F C   1 
ATOM   2693 O O   . VAL A 1 379 ? 167.40215 360.08604 30.70327  1.000 40.55831  ? 414 VAL F O   1 
ATOM   2694 C CB  . VAL A 1 379 ? 164.90543 359.65341 29.03127  1.000 38.09383  ? 414 VAL F CB  1 
ATOM   2695 C CG1 . VAL A 1 379 ? 165.00178 360.99244 28.27580  1.000 35.34659  ? 414 VAL F CG1 1 
ATOM   2696 C CG2 . VAL A 1 379 ? 163.77830 358.77817 28.43332  1.000 41.70578  ? 414 VAL F CG2 1 
ATOM   2697 N N   . SER A 1 380 ? 168.25957 360.24429 28.62051  1.000 37.57622  ? 415 SER F N   1 
ATOM   2698 C CA  . SER A 1 380 ? 169.28319 361.24028 28.91239  1.000 36.62636  ? 415 SER F CA  1 
ATOM   2699 C C   . SER A 1 380 ? 168.86765 362.51001 28.19630  1.000 36.22597  ? 415 SER F C   1 
ATOM   2700 O O   . SER A 1 380 ? 169.01180 362.61596 26.97137  1.000 36.46566  ? 415 SER F O   1 
ATOM   2701 C CB  . SER A 1 380 ? 170.68457 360.80771 28.44780  1.000 31.22368  ? 415 SER F CB  1 
ATOM   2702 O OG  . SER A 1 380 ? 171.11056 359.62994 29.13520  1.000 44.83537  ? 415 SER F OG  1 
ATOM   2703 N N   . CYS A 1 381 ? 168.38074 363.48094 28.96409  1.000 37.78263  ? 416 CYS F N   1 
ATOM   2704 C CA  . CYS A 1 381 ? 167.84231 364.72890 28.42781  1.000 37.12193  ? 416 CYS F CA  1 
ATOM   2705 C C   . CYS A 1 381 ? 168.76483 365.88498 28.79475  1.000 40.42204  ? 416 CYS F C   1 
ATOM   2706 O O   . CYS A 1 381 ? 169.04297 366.11663 29.98274  1.000 39.96866  ? 416 CYS F O   1 
ATOM   2707 C CB  . CYS A 1 381 ? 166.42675 364.97596 28.96413  1.000 39.52438  ? 416 CYS F CB  1 
ATOM   2708 S SG  . CYS A 1 381 ? 165.40289 366.00224 27.89334  1.000 49.45230  ? 416 CYS F SG  1 
ATOM   2709 N N   . TYR A 1 382 ? 169.18576 366.64267 27.78344  1.000 39.40854  ? 417 TYR F N   1 
ATOM   2710 C CA  . TYR A 1 382 ? 170.09691 367.76538 27.99427  1.000 45.21264  ? 417 TYR F CA  1 
ATOM   2711 C C   . TYR A 1 382 ? 169.76016 368.92105 27.05604  1.000 38.11081  ? 417 TYR F C   1 
ATOM   2712 O O   . TYR A 1 382 ? 169.06156 368.73051 26.05520  1.000 37.32203  ? 417 TYR F O   1 
ATOM   2713 C CB  . TYR A 1 382 ? 171.57513 367.34771 27.80482  1.000 46.07802  ? 417 TYR F CB  1 
ATOM   2714 C CG  . TYR A 1 382 ? 171.92467 366.14707 28.64974  1.000 44.01435  ? 417 TYR F CG  1 
ATOM   2715 C CD1 . TYR A 1 382 ? 172.05245 366.27244 30.03742  1.000 42.77396  ? 417 TYR F CD1 1 
ATOM   2716 C CD2 . TYR A 1 382 ? 172.25376 364.92168 28.05971  1.000 40.53460  ? 417 TYR F CD2 1 
ATOM   2717 C CE1 . TYR A 1 382 ? 172.37012 365.18627 30.83125  1.000 35.59594  ? 417 TYR F CE1 1 
ATOM   2718 C CE2 . TYR A 1 382 ? 172.61138 363.82970 28.83747  1.000 38.01492  ? 417 TYR F CE2 1 
ATOM   2719 C CZ  . TYR A 1 382 ? 172.66251 363.96763 30.21619  1.000 40.21373  ? 417 TYR F CZ  1 
ATOM   2720 O OH  . TYR A 1 382 ? 172.98895 362.88759 30.99733  1.000 41.49408  ? 417 TYR F OH  1 
ATOM   2721 N N   . GLY A 1 383 ? 170.09061 370.15155 27.48312  1.000 46.61751  ? 418 GLY F N   1 
ATOM   2722 C CA  . GLY A 1 383 ? 169.85141 371.30034 26.60270  1.000 38.69174  ? 418 GLY F CA  1 
ATOM   2723 C C   . GLY A 1 383 ? 168.37966 371.67858 26.53787  1.000 36.89817  ? 418 GLY F C   1 
ATOM   2724 O O   . GLY A 1 383 ? 167.66369 371.58705 27.53203  1.000 45.85520  ? 418 GLY F O   1 
ATOM   2725 N N   . LYS A 1 384 ? 167.91354 372.03847 25.35499  1.000 41.64696  ? 419 LYS F N   1 
ATOM   2726 C CA  . LYS A 1 384 ? 166.52986 372.41593 25.08410  1.000 43.16997  ? 419 LYS F CA  1 
ATOM   2727 C C   . LYS A 1 384 ? 165.68020 371.26758 24.58933  1.000 45.53193  ? 419 LYS F C   1 
ATOM   2728 O O   . LYS A 1 384 ? 164.57921 371.49372 24.07538  1.000 47.48948  ? 419 LYS F O   1 
ATOM   2729 C CB  . LYS A 1 384 ? 166.49152 373.57598 24.07792  1.000 47.38307  ? 419 LYS F CB  1 
ATOM   2730 C CG  . LYS A 1 384 ? 167.53158 374.69681 24.35336  1.000 40.70338  ? 419 LYS F CG  1 
ATOM   2731 C CD  . LYS A 1 384 ? 167.17152 375.85591 23.43017  1.000 52.13293  ? 419 LYS F CD  1 
ATOM   2732 C CE  . LYS A 1 384 ? 168.18700 376.95783 23.51511  1.000 60.89796  ? 419 LYS F CE  1 
ATOM   2733 N NZ  . LYS A 1 384 ? 167.92879 377.57505 24.85147  1.000 58.93865  ? 419 LYS F NZ  1 
ATOM   2734 N N   . THR A 1 385 ? 166.16493 370.04277 24.69785  1.000 43.54903  ? 420 THR F N   1 
ATOM   2735 C CA  . THR A 1 385 ? 165.44134 368.92713 24.12144  1.000 41.29023  ? 420 THR F CA  1 
ATOM   2736 C C   . THR A 1 385 ? 164.17439 368.65366 24.92011  1.000 42.93911  ? 420 THR F C   1 
ATOM   2737 O O   . THR A 1 385 ? 164.15155 368.74355 26.15508  1.000 38.68191  ? 420 THR F O   1 
ATOM   2738 C CB  . THR A 1 385 ? 166.31278 367.66504 24.07769  1.000 47.08137  ? 420 THR F CB  1 
ATOM   2739 O OG1 . THR A 1 385 ? 167.58061 367.99815 23.51992  1.000 47.70991  ? 420 THR F OG1 1 
ATOM   2740 C CG2 . THR A 1 385 ? 165.67596 366.61961 23.15352  1.000 39.27332  ? 420 THR F CG2 1 
ATOM   2741 N N   . LYS A 1 386 ? 163.11356 368.33500 24.20024  1.000 38.80201  ? 421 LYS F N   1 
ATOM   2742 C CA  . LYS A 1 386 ? 161.80970 368.00798 24.78300  1.000 43.94167  ? 421 LYS F CA  1 
ATOM   2743 C C   . LYS A 1 386 ? 161.72977 366.48474 24.96089  1.000 41.73946  ? 421 LYS F C   1 
ATOM   2744 O O   . LYS A 1 386 ? 161.73375 365.74959 23.97267  1.000 37.69494  ? 421 LYS F O   1 
ATOM   2745 C CB  . LYS A 1 386 ? 160.67258 368.48383 23.87559  1.000 41.98655  ? 421 LYS F CB  1 
ATOM   2746 C CG  . LYS A 1 386 ? 159.28552 368.09239 24.39665  1.000 44.38618  ? 421 LYS F CG  1 
ATOM   2747 C CD  . LYS A 1 386 ? 158.17608 368.53273 23.44173  1.000 50.25975  ? 421 LYS F CD  1 
ATOM   2748 C CE  . LYS A 1 386 ? 156.80641 368.12878 23.95283  1.000 57.17137  ? 421 LYS F CE  1 
ATOM   2749 N NZ  . LYS A 1 386 ? 155.75300 368.48086 22.94829  1.000 70.21647  ? 421 LYS F NZ  1 
ATOM   2750 N N   . CYS A 1 387 ? 161.95819 365.98621 26.17419  1.000 36.98812  ? 422 CYS F N   1 
ATOM   2751 C CA  . CYS A 1 387 ? 161.84846 364.55601 26.45539  1.000 34.55289  ? 422 CYS F CA  1 
ATOM   2752 C C   . CYS A 1 387 ? 160.57797 364.21652 27.24088  1.000 37.85519  ? 422 CYS F C   1 
ATOM   2753 O O   . CYS A 1 387 ? 160.37018 364.73590 28.33855  1.000 44.13163  ? 422 CYS F O   1 
ATOM   2754 C CB  . CYS A 1 387 ? 163.08977 364.06994 27.20338  1.000 38.00880  ? 422 CYS F CB  1 
ATOM   2755 S SG  . CYS A 1 387 ? 164.60208 364.70163 26.42866  1.000 43.12806  ? 422 CYS F SG  1 
ATOM   2756 N N   . THR A 1 388 ? 159.86793 363.17984 26.82294  1.000 39.21617  ? 423 THR F N   1 
ATOM   2757 C CA  . THR A 1 388 ? 158.59527 362.85089 27.44747  1.000 37.74440  ? 423 THR F CA  1 
ATOM   2758 C C   . THR A 1 388 ? 158.31069 361.36497 27.25487  1.000 43.19649  ? 423 THR F C   1 
ATOM   2759 O O   . THR A 1 388 ? 158.90559 360.68679 26.40601  1.000 42.64115  ? 423 THR F O   1 
ATOM   2760 C CB  . THR A 1 388 ? 157.42933 363.62904 26.84958  1.000 41.25860  ? 423 THR F CB  1 
ATOM   2761 O OG1 . THR A 1 388 ? 157.34388 363.28107 25.47481  1.000 42.56375  ? 423 THR F OG1 1 
ATOM   2762 C CG2 . THR A 1 388 ? 157.60965 365.16031 26.98675  1.000 33.04733  ? 423 THR F CG2 1 
ATOM   2763 N N   . ALA A 1 389 ? 157.36388 360.88469 28.04454  1.000 37.88731  ? 424 ALA F N   1 
ATOM   2764 C CA  . ALA A 1 389 ? 156.85173 359.52474 28.00877  1.000 42.95392  ? 424 ALA F CA  1 
ATOM   2765 C C   . ALA A 1 389 ? 155.32996 359.55196 28.00692  1.000 45.20577  ? 424 ALA F C   1 
ATOM   2766 O O   . ALA A 1 389 ? 154.72195 360.27657 28.80364  1.000 46.98205  ? 424 ALA F O   1 
ATOM   2767 C CB  . ALA A 1 389 ? 157.34310 358.70051 29.18450  1.000 35.78923  ? 424 ALA F CB  1 
ATOM   2768 N N   . SER A 1 390 ? 154.73200 358.88483 27.02485  1.000 38.23173  ? 425 SER F N   1 
ATOM   2769 C CA  . SER A 1 390 ? 153.30161 358.90914 26.79964  1.000 45.22482  ? 425 SER F CA  1 
ATOM   2770 C C   . SER A 1 390 ? 152.64757 357.53720 26.87172  1.000 47.11082  ? 425 SER F C   1 
ATOM   2771 O O   . SER A 1 390 ? 153.28250 356.47640 26.76916  1.000 43.88043  ? 425 SER F O   1 
ATOM   2772 C CB  . SER A 1 390 ? 152.94177 359.48701 25.43564  1.000 36.22094  ? 425 SER F CB  1 
ATOM   2773 O OG  . SER A 1 390 ? 153.50489 360.76650 25.31080  1.000 45.47328  ? 425 SER F OG  1 
ATOM   2774 N N   . ASN A 1 391 ? 151.36222 357.62049 27.18275  1.000 45.05750  ? 426 ASN F N   1 
ATOM   2775 C CA  . ASN A 1 391 ? 150.40627 356.54147 27.11437  1.000 44.43821  ? 426 ASN F CA  1 
ATOM   2776 C C   . ASN A 1 391 ? 149.50119 356.80534 25.92550  1.000 49.74962  ? 426 ASN F C   1 
ATOM   2777 O O   . ASN A 1 391 ? 149.13641 357.95629 25.66136  1.000 50.81630  ? 426 ASN F O   1 
ATOM   2778 C CB  . ASN A 1 391 ? 149.57398 356.47464 28.38846  1.000 51.04551  ? 426 ASN F CB  1 
ATOM   2779 C CG  . ASN A 1 391 ? 148.57817 355.33602 28.36391  1.000 54.82909  ? 426 ASN F CG  1 
ATOM   2780 O OD1 . ASN A 1 391 ? 147.47228 355.53098 27.85793  1.000 55.34471  ? 426 ASN F OD1 1 
ATOM   2781 N ND2 . ASN A 1 391 ? 148.91917 354.18979 28.92189  1.000 49.81771  ? 426 ASN F ND2 1 
ATOM   2782 N N   . LYS A 1 392 ? 149.09612 355.73744 25.24019  1.000 52.85609  ? 427 LYS F N   1 
ATOM   2783 C CA  . LYS A 1 392 ? 148.36162 355.91212 23.98792  1.000 58.11259  ? 427 LYS F CA  1 
ATOM   2784 C C   . LYS A 1 392 ? 147.04078 356.66743 24.19267  1.000 58.43667  ? 427 LYS F C   1 
ATOM   2785 O O   . LYS A 1 392 ? 146.62596 357.44719 23.32593  1.000 61.45016  ? 427 LYS F O   1 
ATOM   2786 C CB  . LYS A 1 392 ? 148.11935 354.55729 23.32969  1.000 66.32356  ? 427 LYS F CB  1 
ATOM   2787 C CG  . LYS A 1 392 ? 147.65678 354.67759 21.88510  1.000 71.39848  ? 427 LYS F CG  1 
ATOM   2788 C CD  . LYS A 1 392 ? 147.15763 353.34549 21.34793  1.000 75.51798  ? 427 LYS F CD  1 
ATOM   2789 C CE  . LYS A 1 392 ? 145.84948 353.53120 20.58485  1.000 76.94557  ? 427 LYS F CE  1 
ATOM   2790 N NZ  . LYS A 1 392 ? 146.00953 353.27925 19.12138  1.000 71.77914  ? 427 LYS F NZ  1 
ATOM   2791 N N   . ASN A 1 393 ? 146.37381 356.47214 25.33289  1.000 55.50747  ? 428 ASN F N   1 
ATOM   2792 C CA  . ASN A 1 393 ? 145.07286 357.08952 25.55391  1.000 57.28217  ? 428 ASN F CA  1 
ATOM   2793 C C   . ASN A 1 393 ? 145.08467 358.26840 26.51649  1.000 61.20417  ? 428 ASN F C   1 
ATOM   2794 O O   . ASN A 1 393 ? 144.20104 359.12356 26.43069  1.000 67.39591  ? 428 ASN F O   1 
ATOM   2795 C CB  . ASN A 1 393 ? 144.08271 356.04571 26.09518  1.000 63.99078  ? 428 ASN F CB  1 
ATOM   2796 C CG  . ASN A 1 393 ? 144.04988 354.77509 25.24578  1.000 67.84881  ? 428 ASN F CG  1 
ATOM   2797 O OD1 . ASN A 1 393 ? 143.39095 354.73479 24.22356  1.000 71.38242  ? 428 ASN F OD1 1 
ATOM   2798 N ND2 . ASN A 1 393 ? 144.70940 353.72198 25.71044  1.000 66.76251  ? 428 ASN F ND2 1 
ATOM   2799 N N   . ARG A 1 394 ? 146.08916 358.37525 27.36600  1.000 54.93087  ? 429 ARG F N   1 
ATOM   2800 C CA  . ARG A 1 394 ? 146.21540 359.46900 28.31112  1.000 51.70970  ? 429 ARG F CA  1 
ATOM   2801 C C   . ARG A 1 394 ? 147.07900 360.61389 27.79583  1.000 50.88602  ? 429 ARG F C   1 
ATOM   2802 O O   . ARG A 1 394 ? 147.02450 361.70087 28.37570  1.000 52.76532  ? 429 ARG F O   1 
ATOM   2803 C CB  . ARG A 1 394 ? 146.80032 358.92614 29.61334  1.000 50.99566  ? 429 ARG F CB  1 
ATOM   2804 C CG  . ARG A 1 394 ? 146.22558 357.57534 29.93499  1.000 50.79165  ? 429 ARG F CG  1 
ATOM   2805 C CD  . ARG A 1 394 ? 146.22973 357.23532 31.40299  1.000 56.77565  ? 429 ARG F CD  1 
ATOM   2806 N NE  . ARG A 1 394 ? 145.53617 355.96539 31.60646  1.000 65.59374  ? 429 ARG F NE  1 
ATOM   2807 C CZ  . ARG A 1 394 ? 146.09103 354.87627 32.12261  1.000 63.82997  ? 429 ARG F CZ  1 
ATOM   2808 N NH1 . ARG A 1 394 ? 147.38820 354.82174 32.40635  1.000 63.75746  ? 429 ARG F NH1 1 
ATOM   2809 N NH2 . ARG A 1 394 ? 145.33441 353.80362 32.33070  1.000 74.47934  ? 429 ARG F NH2 1 
ATOM   2810 N N   . GLY A 1 395 ? 147.96994 360.37512 26.82980  1.000 53.61721  ? 430 GLY F N   1 
ATOM   2811 C CA  . GLY A 1 395 ? 148.84123 361.44543 26.36312  1.000 43.30699  ? 430 GLY F CA  1 
ATOM   2812 C C   . GLY A 1 395 ? 150.14492 361.41767 27.13975  1.000 43.14164  ? 430 GLY F C   1 
ATOM   2813 O O   . GLY A 1 395 ? 150.57640 360.36949 27.63052  1.000 40.58962  ? 430 GLY F O   1 
ATOM   2814 N N   . ILE A 1 396 ? 150.76660 362.58386 27.27119  1.000 43.65772  ? 431 ILE F N   1 
ATOM   2815 C CA  . ILE A 1 396 ? 152.02802 362.71431 27.98269  1.000 39.88428  ? 431 ILE F CA  1 
ATOM   2816 C C   . ILE A 1 396 ? 151.79328 362.48828 29.46759  1.000 44.86285  ? 431 ILE F C   1 
ATOM   2817 O O   . ILE A 1 396 ? 151.02592 363.21142 30.10929  1.000 51.42858  ? 431 ILE F O   1 
ATOM   2818 C CB  . ILE A 1 396 ? 152.64790 364.09137 27.73653  1.000 36.45049  ? 431 ILE F CB  1 
ATOM   2819 C CG1 . ILE A 1 396 ? 153.09932 364.19809 26.29183  1.000 32.14545  ? 431 ILE F CG1 1 
ATOM   2820 C CG2 . ILE A 1 396 ? 153.81146 364.28390 28.69353  1.000 38.79804  ? 431 ILE F CG2 1 
ATOM   2821 C CD1 . ILE A 1 396 ? 153.61370 365.60531 25.92555  1.000 33.83039  ? 431 ILE F CD1 1 
ATOM   2822 N N   . ILE A 1 397 ? 152.43502 361.46721 30.02107  1.000 42.45467  ? 432 ILE F N   1 
ATOM   2823 C CA  . ILE A 1 397 ? 152.32064 361.16008 31.44185  1.000 41.72111  ? 432 ILE F CA  1 
ATOM   2824 C C   . ILE A 1 397 ? 153.57728 361.48877 32.23330  1.000 43.00183  ? 432 ILE F C   1 
ATOM   2825 O O   . ILE A 1 397 ? 153.53603 361.45289 33.47626  1.000 45.11652  ? 432 ILE F O   1 
ATOM   2826 C CB  . ILE A 1 397 ? 151.87051 359.70601 31.68646  1.000 46.95538  ? 432 ILE F CB  1 
ATOM   2827 C CG1 . ILE A 1 397 ? 152.81446 358.71967 31.00149  1.000 44.57108  ? 432 ILE F CG1 1 
ATOM   2828 C CG2 . ILE A 1 397 ? 150.43254 359.56367 31.23311  1.000 42.07642  ? 432 ILE F CG2 1 
ATOM   2829 C CD1 . ILE A 1 397 ? 153.82739 358.17452 31.93426  1.000 56.03874  ? 432 ILE F CD1 1 
ATOM   2830 N N   . LYS A 1 398 ? 154.69373 361.77279 31.57025  1.000 41.73386  ? 433 LYS F N   1 
ATOM   2831 C CA  . LYS A 1 398 ? 155.91454 362.16363 32.25830  1.000 39.81629  ? 433 LYS F CA  1 
ATOM   2832 C C   . LYS A 1 398 ? 156.77378 363.02811 31.35647  1.000 38.21204  ? 433 LYS F C   1 
ATOM   2833 O O   . LYS A 1 398 ? 156.89535 362.77506 30.15643  1.000 42.05132  ? 433 LYS F O   1 
ATOM   2834 C CB  . LYS A 1 398 ? 156.74468 360.94809 32.71589  1.000 44.61334  ? 433 LYS F CB  1 
ATOM   2835 C CG  . LYS A 1 398 ? 158.03079 361.40023 33.40085  1.000 43.74724  ? 433 LYS F CG  1 
ATOM   2836 C CD  . LYS A 1 398 ? 158.81917 360.35146 34.13505  1.000 49.57786  ? 433 LYS F CD  1 
ATOM   2837 C CE  . LYS A 1 398 ? 159.97699 361.04517 34.88575  1.000 45.18599  ? 433 LYS F CE  1 
ATOM   2838 N NZ  . LYS A 1 398 ? 160.16122 360.59201 36.27974  1.000 57.58040  ? 433 LYS F NZ  1 
ATOM   2839 N N   . THR A 1 399 ? 157.22064 364.13821 31.91661  1.000 38.90580  ? 434 THR F N   1 
ATOM   2840 C CA  . THR A 1 399 ? 158.15804 365.03551 31.26853  1.000 42.22041  ? 434 THR F CA  1 
ATOM   2841 C C   . THR A 1 399 ? 159.47159 364.96559 32.00676  1.000 45.12021  ? 434 THR F C   1 
ATOM   2842 O O   . THR A 1 399 ? 159.49433 365.11104 33.23641  1.000 45.02232  ? 434 THR F O   1 
ATOM   2843 C CB  . THR A 1 399 ? 157.61806 366.45750 31.23271  1.000 42.87486  ? 434 THR F CB  1 
ATOM   2844 O OG1 . THR A 1 399 ? 156.33452 366.43033 30.57794  1.000 39.33485  ? 434 THR F OG1 1 
ATOM   2845 C CG2 . THR A 1 399 ? 158.58318 367.38920 30.49846  1.000 38.52497  ? 434 THR F CG2 1 
ATOM   2846 N N   . PHE A 1 400 ? 160.52761 364.58238 31.28120  1.000 39.29978  ? 435 PHE F N   1 
ATOM   2847 C CA  . PHE A 1 400 ? 161.84326 364.45535 31.88493  1.000 40.47423  ? 435 PHE F CA  1 
ATOM   2848 C C   . PHE A 1 400 ? 162.49165 365.82197 31.98866  1.000 43.59942  ? 435 PHE F C   1 
ATOM   2849 O O   . PHE A 1 400 ? 162.33352 366.67320 31.10351  1.000 45.00443  ? 435 PHE F O   1 
ATOM   2850 C CB  . PHE A 1 400 ? 162.75128 363.49972 31.08378  1.000 40.17338  ? 435 PHE F CB  1 
ATOM   2851 C CG  . PHE A 1 400 ? 162.21402 362.09629 30.96430  1.000 38.45807  ? 435 PHE F CG  1 
ATOM   2852 C CD1 . PHE A 1 400 ? 162.46046 361.18427 31.96977  1.000 36.02667  ? 435 PHE F CD1 1 
ATOM   2853 C CD2 . PHE A 1 400 ? 161.41689 361.71603 29.91360  1.000 35.51138  ? 435 PHE F CD2 1 
ATOM   2854 C CE1 . PHE A 1 400 ? 161.98059 359.90635 31.89547  1.000 40.94277  ? 435 PHE F CE1 1 
ATOM   2855 C CE2 . PHE A 1 400 ? 160.92247 360.43029 29.83659  1.000 36.49427  ? 435 PHE F CE2 1 
ATOM   2856 C CZ  . PHE A 1 400 ? 161.19816 359.52810 30.82093  1.000 35.67462  ? 435 PHE F CZ  1 
ATOM   2857 N N   . SER A 1 401 ? 163.16959 366.05792 33.09379  1.000 43.69966  ? 436 SER F N   1 
ATOM   2858 C CA  . SER A 1 401 ? 163.95556 367.27445 33.15037  1.000 49.76779  ? 436 SER F CA  1 
ATOM   2859 C C   . SER A 1 401 ? 165.37090 366.90878 32.70307  1.000 49.94735  ? 436 SER F C   1 
ATOM   2860 O O   . SER A 1 401 ? 165.68012 365.74548 32.42524  1.000 48.34710  ? 436 SER F O   1 
ATOM   2861 C CB  . SER A 1 401 ? 163.94611 367.87637 34.54426  1.000 45.90632  ? 436 SER F CB  1 
ATOM   2862 O OG  . SER A 1 401 ? 164.42770 366.91394 35.45337  1.000 53.85714  ? 436 SER F OG  1 
ATOM   2863 N N   . ASN A 1 402 ? 166.25535 367.89202 32.73808  1.000 45.25711  ? 437 ASN F N   1 
ATOM   2864 C CA  . ASN A 1 402 ? 167.63925 367.71862 32.33341  1.000 48.90210  ? 437 ASN F CA  1 
ATOM   2865 C C   . ASN A 1 402 ? 168.35869 366.80751 33.31208  1.000 48.66164  ? 437 ASN F C   1 
ATOM   2866 O O   . ASN A 1 402 ? 168.19532 366.93207 34.52474  1.000 48.02875  ? 437 ASN F O   1 
ATOM   2867 C CB  . ASN A 1 402 ? 168.32040 369.07733 32.21344  1.000 44.19238  ? 437 ASN F CB  1 
ATOM   2868 C CG  . ASN A 1 402 ? 168.10884 369.68088 30.84012  1.000 49.99371  ? 437 ASN F CG  1 
ATOM   2869 O OD1 . ASN A 1 402 ? 167.29036 369.17819 30.05809  1.000 54.09414  ? 437 ASN F OD1 1 
ATOM   2870 N ND2 . ASN A 1 402 ? 168.76565 370.80115 30.56263  1.000 61.35371  ? 437 ASN F ND2 1 
ATOM   2871 N N   . GLY A 1 403 ? 169.04989 365.80472 32.76283  1.000 41.83237  ? 438 GLY F N   1 
ATOM   2872 C CA  . GLY A 1 403 ? 169.76311 364.76413 33.47193  1.000 42.47587  ? 438 GLY F CA  1 
ATOM   2873 C C   . GLY A 1 403 ? 169.40027 363.39765 32.90720  1.000 42.77174  ? 438 GLY F C   1 
ATOM   2874 O O   . GLY A 1 403 ? 168.85619 363.27429 31.80558  1.000 37.31862  ? 438 GLY F O   1 
ATOM   2875 N N   . CYS A 1 404 ? 169.76320 362.34369 33.62599  1.000 41.30025  ? 439 CYS F N   1 
ATOM   2876 C CA  . CYS A 1 404 ? 169.45764 360.99561 33.19101  1.000 38.96815  ? 439 CYS F CA  1 
ATOM   2877 C C   . CYS A 1 404 ? 168.38024 360.44489 34.09994  1.000 42.67138  ? 439 CYS F C   1 
ATOM   2878 O O   . CYS A 1 404 ? 168.57912 360.37910 35.31584  1.000 40.96979  ? 439 CYS F O   1 
ATOM   2879 C CB  . CYS A 1 404 ? 170.71140 360.11434 33.23480  1.000 46.74898  ? 439 CYS F CB  1 
ATOM   2880 S SG  . CYS A 1 404 ? 170.38151 358.33627 32.87407  1.000 49.29027  ? 439 CYS F SG  1 
ATOM   2881 N N   . ASP A 1 405 ? 167.32441 359.90511 33.50240  1.000 42.25782  ? 440 ASP F N   1 
ATOM   2882 C CA  . ASP A 1 405 ? 166.19890 359.38999 34.25807  1.000 38.34537  ? 440 ASP F CA  1 
ATOM   2883 C C   . ASP A 1 405 ? 165.72798 358.09676 33.59909  1.000 37.01199  ? 440 ASP F C   1 
ATOM   2884 O O   . ASP A 1 405 ? 166.20513 357.70834 32.52420  1.000 42.33332  ? 440 ASP F O   1 
ATOM   2885 C CB  . ASP A 1 405 ? 165.05418 360.42890 34.25824  1.000 41.05848  ? 440 ASP F CB  1 
ATOM   2886 C CG  . ASP A 1 405 ? 164.16110 360.36295 35.50300  1.000 41.35945  ? 440 ASP F CG  1 
ATOM   2887 O OD1 . ASP A 1 405 ? 164.18126 359.35086 36.24701  1.000 41.45512  ? 440 ASP F OD1 1 
ATOM   2888 O OD2 . ASP A 1 405 ? 163.29960 361.26236 35.62380  1.000 47.58287  ? 440 ASP F OD2 1 
ATOM   2889 N N   . TYR A 1 406 ? 164.66791 357.52521 34.15658  1.000 39.03423  ? 441 TYR F N   1 
ATOM   2890 C CA  . TYR A 1 406 ? 164.13743 356.24192 33.73240  1.000 37.73864  ? 441 TYR F CA  1 
ATOM   2891 C C   . TYR A 1 406 ? 162.64138 356.16253 33.97249  1.000 42.47614  ? 441 TYR F C   1 
ATOM   2892 O O   . TYR A 1 406 ? 162.10855 356.79583 34.88705  1.000 42.74313  ? 441 TYR F O   1 
ATOM   2893 C CB  . TYR A 1 406 ? 164.80558 355.13158 34.55432  1.000 35.78800  ? 441 TYR F CB  1 
ATOM   2894 C CG  . TYR A 1 406 ? 164.24081 353.73149 34.38711  1.000 40.74151  ? 441 TYR F CG  1 
ATOM   2895 C CD1 . TYR A 1 406 ? 164.67284 352.88963 33.36861  1.000 40.84146  ? 441 TYR F CD1 1 
ATOM   2896 C CD2 . TYR A 1 406 ? 163.26750 353.24997 35.25804  1.000 42.16402  ? 441 TYR F CD2 1 
ATOM   2897 C CE1 . TYR A 1 406 ? 164.15964 351.59946 33.23288  1.000 41.07453  ? 441 TYR F CE1 1 
ATOM   2898 C CE2 . TYR A 1 406 ? 162.74347 351.96826 35.12737  1.000 35.85537  ? 441 TYR F CE2 1 
ATOM   2899 C CZ  . TYR A 1 406 ? 163.19551 351.14691 34.11469  1.000 44.20106  ? 441 TYR F CZ  1 
ATOM   2900 O OH  . TYR A 1 406 ? 162.68424 349.86048 33.98281  1.000 42.36831  ? 441 TYR F OH  1 
ATOM   2901 N N   . VAL A 1 407 ? 161.95968 355.40187 33.13837  1.000 37.75607  ? 442 VAL F N   1 
ATOM   2902 C CA  . VAL A 1 407 ? 160.53698 355.19797 33.33715  1.000 43.13385  ? 442 VAL F CA  1 
ATOM   2903 C C   . VAL A 1 407 ? 160.26592 353.73787 33.01312  1.000 43.84375  ? 442 VAL F C   1 
ATOM   2904 O O   . VAL A 1 407 ? 160.82989 353.20314 32.04732  1.000 45.96011  ? 442 VAL F O   1 
ATOM   2905 C CB  . VAL A 1 407 ? 159.69518 356.14704 32.48167  1.000 43.49081  ? 442 VAL F CB  1 
ATOM   2906 C CG1 . VAL A 1 407 ? 159.88291 355.84789 30.96928  1.000 41.33329  ? 442 VAL F CG1 1 
ATOM   2907 C CG2 . VAL A 1 407 ? 158.29626 356.13091 32.93840  1.000 47.65018  ? 442 VAL F CG2 1 
ATOM   2908 N N   . SER A 1 408 ? 159.38097 353.10162 33.78056  1.000 42.14169  ? 443 SER F N   1 
ATOM   2909 C CA  . SER A 1 408 ? 158.98808 351.69952 33.58393  1.000 46.56789  ? 443 SER F CA  1 
ATOM   2910 C C   . SER A 1 408 ? 157.97880 351.59482 32.44403  1.000 44.29969  ? 443 SER F C   1 
ATOM   2911 O O   . SER A 1 408 ? 157.40461 352.59427 32.00748  1.000 46.60783  ? 443 SER F O   1 
ATOM   2912 C CB  . SER A 1 408 ? 158.37056 351.05504 34.82975  1.000 44.52495  ? 443 SER F CB  1 
ATOM   2913 O OG  . SER A 1 408 ? 157.16007 351.69171 35.14344  1.000 55.18548  ? 443 SER F OG  1 
ATOM   2914 N N   . ASN A 1 409 ? 157.77105 350.36755 31.94745  1.000 43.69652  ? 444 ASN F N   1 
ATOM   2915 C CA  . ASN A 1 409 ? 156.78181 350.15222 30.88542  1.000 47.09403  ? 444 ASN F CA  1 
ATOM   2916 C C   . ASN A 1 409 ? 155.35760 350.07224 31.43507  1.000 46.39592  ? 444 ASN F C   1 
ATOM   2917 O O   . ASN A 1 409 ? 154.40153 350.01373 30.65434  1.000 46.69601  ? 444 ASN F O   1 
ATOM   2918 C CB  . ASN A 1 409 ? 157.03115 348.85296 30.11399  1.000 40.28109  ? 444 ASN F CB  1 
ATOM   2919 C CG  . ASN A 1 409 ? 156.97346 347.60109 30.99201  1.000 49.14752  ? 444 ASN F CG  1 
ATOM   2920 O OD1 . ASN A 1 409 ? 156.76840 347.65450 32.21870  1.000 49.18056  ? 444 ASN F OD1 1 
ATOM   2921 N ND2 . ASN A 1 409 ? 157.25634 346.45892 30.36543  1.000 49.62665  ? 444 ASN F ND2 1 
ATOM   2922 N N   . LYS A 1 410 ? 155.18365 350.09365 32.74702  1.000 46.57284  ? 445 LYS F N   1 
ATOM   2923 C CA  . LYS A 1 410 ? 153.84837 349.99072 33.33828  1.000 50.51043  ? 445 LYS F CA  1 
ATOM   2924 C C   . LYS A 1 410 ? 153.08001 351.28129 33.09277  1.000 47.95730  ? 445 LYS F C   1 
ATOM   2925 O O   . LYS A 1 410 ? 153.42805 352.33544 33.62020  1.000 50.78700  ? 445 LYS F O   1 
ATOM   2926 C CB  . LYS A 1 410 ? 153.94192 349.74080 34.83970  1.000 50.11443  ? 445 LYS F CB  1 
ATOM   2927 C CG  . LYS A 1 410 ? 153.74544 348.29750 35.25546  1.000 59.56840  ? 445 LYS F CG  1 
ATOM   2928 C CD  . LYS A 1 410 ? 155.04343 347.54985 35.46481  1.000 66.77276  ? 445 LYS F CD  1 
ATOM   2929 C CE  . LYS A 1 410 ? 154.80209 346.11654 35.98966  1.000 66.14580  ? 445 LYS F CE  1 
ATOM   2930 N NZ  . LYS A 1 410 ? 153.69703 345.41690 35.27901  1.000 70.18767  ? 445 LYS F NZ  1 
ATOM   2931 N N   . GLY A 1 411 ? 152.17619 351.25824 32.11359  1.000 50.08637  ? 446 GLY F N   1 
ATOM   2932 C CA  . GLY A 1 411 ? 151.38670 352.42640 31.80104  1.000 42.32741  ? 446 GLY F CA  1 
ATOM   2933 C C   . GLY A 1 411 ? 151.97097 353.29052 30.70202  1.000 50.86828  ? 446 GLY F C   1 
ATOM   2934 O O   . GLY A 1 411 ? 151.31194 354.25327 30.27659  1.000 47.29509  ? 446 GLY F O   1 
ATOM   2935 N N   . VAL A 1 412 ? 153.19805 352.99347 30.25991  1.000 45.17638  ? 447 VAL F N   1 
ATOM   2936 C CA  . VAL A 1 412 ? 153.91954 353.74412 29.23182  1.000 43.42368  ? 447 VAL F CA  1 
ATOM   2937 C C   . VAL A 1 412 ? 153.94921 352.93633 27.94509  1.000 45.92674  ? 447 VAL F C   1 
ATOM   2938 O O   . VAL A 1 412 ? 154.32146 351.75820 27.96314  1.000 46.99231  ? 447 VAL F O   1 
ATOM   2939 C CB  . VAL A 1 412 ? 155.36153 354.04442 29.67659  1.000 41.04935  ? 447 VAL F CB  1 
ATOM   2940 C CG1 . VAL A 1 412 ? 156.13650 354.73571 28.55363  1.000 42.43143  ? 447 VAL F CG1 1 
ATOM   2941 C CG2 . VAL A 1 412 ? 155.36896 354.89200 30.91665  1.000 44.69824  ? 447 VAL F CG2 1 
ATOM   2942 N N   . ASP A 1 413 ? 153.64742 353.58966 26.82427  1.000 41.45448  ? 448 ASP F N   1 
ATOM   2943 C CA  . ASP A 1 413 ? 153.68186 352.98179 25.49690  1.000 40.75436  ? 448 ASP F CA  1 
ATOM   2944 C C   . ASP A 1 413 ? 154.83780 353.49587 24.64905  1.000 45.01706  ? 448 ASP F C   1 
ATOM   2945 O O   . ASP A 1 413 ? 155.47419 352.72340 23.92522  1.000 43.95815  ? 448 ASP F O   1 
ATOM   2946 C CB  . ASP A 1 413 ? 152.34628 353.23519 24.79179  1.000 40.09644  ? 448 ASP F CB  1 
ATOM   2947 C CG  . ASP A 1 413 ? 151.19651 352.51837 25.50300  1.000 55.13218  ? 448 ASP F CG  1 
ATOM   2948 O OD1 . ASP A 1 413 ? 151.45578 351.41508 26.05545  1.000 51.14462  ? 448 ASP F OD1 1 
ATOM   2949 O OD2 . ASP A 1 413 ? 150.08415 353.10210 25.60268  1.000 58.30434  ? 448 ASP F OD2 1 
ATOM   2950 N N   . THR A 1 414 ? 155.04876 354.80630 24.63565  1.000 39.24506  ? 449 THR F N   1 
ATOM   2951 C CA  . THR A 1 414 ? 156.09407 355.42227 23.84760  1.000 42.69076  ? 449 THR F CA  1 
ATOM   2952 C C   . THR A 1 414 ? 156.88071 356.42251 24.69310  1.000 43.80313  ? 449 THR F C   1 
ATOM   2953 O O   . THR A 1 414 ? 156.42326 356.87845 25.75406  1.000 39.41027  ? 449 THR F O   1 
ATOM   2954 C CB  . THR A 1 414 ? 155.52634 356.12030 22.63725  1.000 40.02026  ? 449 THR F CB  1 
ATOM   2955 O OG1 . THR A 1 414 ? 154.63419 357.12572 23.09445  1.000 44.95579  ? 449 THR F OG1 1 
ATOM   2956 C CG2 . THR A 1 414 ? 154.77123 355.11947 21.78914  1.000 41.15101  ? 449 THR F CG2 1 
ATOM   2957 N N   . VAL A 1 415 ? 158.08619 356.72573 24.19845  1.000 38.70404  ? 450 VAL F N   1 
ATOM   2958 C CA  . VAL A 1 415 ? 159.00770 357.71676 24.74368  1.000 38.37170  ? 450 VAL F CA  1 
ATOM   2959 C C   . VAL A 1 415 ? 159.51091 358.60274 23.60103  1.000 45.49662  ? 450 VAL F C   1 
ATOM   2960 O O   . VAL A 1 415 ? 159.80784 358.09780 22.51134  1.000 43.23141  ? 450 VAL F O   1 
ATOM   2961 C CB  . VAL A 1 415 ? 160.18684 357.06620 25.47596  1.000 40.24296  ? 450 VAL F CB  1 
ATOM   2962 C CG1 . VAL A 1 415 ? 161.27593 358.08289 25.71467  1.000 42.00975  ? 450 VAL F CG1 1 
ATOM   2963 C CG2 . VAL A 1 415 ? 159.71424 356.49099 26.78749  1.000 42.67603  ? 450 VAL F CG2 1 
ATOM   2964 N N   . SER A 1 416 ? 159.39418 359.92047 23.76379  1.000 37.63635  ? 451 SER F N   1 
ATOM   2965 C CA  . SER A 1 416 ? 159.82744 360.87790 22.75447  1.000 39.49303  ? 451 SER F CA  1 
ATOM   2966 C C   . SER A 1 416 ? 161.02387 361.66480 23.25921  1.000 40.41968  ? 451 SER F C   1 
ATOM   2967 O O   . SER A 1 416 ? 161.01627 362.17422 24.38899  1.000 40.54589  ? 451 SER F O   1 
ATOM   2968 C CB  . SER A 1 416 ? 158.72369 361.84800 22.31330  1.000 37.02964  ? 451 SER F CB  1 
ATOM   2969 O OG  . SER A 1 416 ? 157.70263 361.14163 21.64083  1.000 50.29227  ? 451 SER F OG  1 
ATOM   2970 N N   . VAL A 1 417 ? 162.06590 361.72456 22.44060  1.000 35.95668  ? 452 VAL F N   1 
ATOM   2971 C CA  . VAL A 1 417 ? 163.24471 362.51868 22.73883  1.000 38.13918  ? 452 VAL F CA  1 
ATOM   2972 C C   . VAL A 1 417 ? 163.48197 363.37984 21.51597  1.000 42.73960  ? 452 VAL F C   1 
ATOM   2973 O O   . VAL A 1 417 ? 163.73507 362.84796 20.42185  1.000 45.79405  ? 452 VAL F O   1 
ATOM   2974 C CB  . VAL A 1 417 ? 164.47253 361.65812 23.06434  1.000 42.63226  ? 452 VAL F CB  1 
ATOM   2975 C CG1 . VAL A 1 417 ? 165.70114 362.54555 23.18724  1.000 39.53713  ? 452 VAL F CG1 1 
ATOM   2976 C CG2 . VAL A 1 417 ? 164.21788 360.89052 24.35552  1.000 38.97761  ? 452 VAL F CG2 1 
ATOM   2977 N N   . GLY A 1 418 ? 163.22893 364.68133 21.64930  1.000 42.30862  ? 453 GLY F N   1 
ATOM   2978 C CA  . GLY A 1 418 ? 163.34197 365.56390 20.49768  1.000 38.19377  ? 453 GLY F CA  1 
ATOM   2979 C C   . GLY A 1 418 ? 162.29030 365.21065 19.46601  1.000 42.70287  ? 453 GLY F C   1 
ATOM   2980 O O   . GLY A 1 418 ? 161.14404 364.91531 19.81193  1.000 40.85772  ? 453 GLY F O   1 
ATOM   2981 N N   . ASN A 1 419 ? 162.71225 365.02957 18.21230  1.000 44.30556  ? 454 ASN F N   1 
ATOM   2982 C CA  . ASN A 1 419 ? 161.78268 364.64322 17.16297  1.000 40.90082  ? 454 ASN F CA  1 
ATOM   2983 C C   . ASN A 1 419 ? 161.72547 363.15018 16.93704  1.000 40.97879  ? 454 ASN F C   1 
ATOM   2984 O O   . ASN A 1 419 ? 161.19409 362.72572 15.90735  1.000 46.22791  ? 454 ASN F O   1 
ATOM   2985 C CB  . ASN A 1 419 ? 162.16682 365.29541 15.82713  1.000 41.42462  ? 454 ASN F CB  1 
ATOM   2986 C CG  . ASN A 1 419 ? 162.15314 366.82752 15.86066  1.000 46.95642  ? 454 ASN F CG  1 
ATOM   2987 O OD1 . ASN A 1 419 ? 161.41517 367.45250 16.62836  1.000 48.91054  ? 454 ASN F OD1 1 
ATOM   2988 N ND2 . ASN A 1 419 ? 163.01683 367.43528 15.04165  1.000 45.20367  ? 454 ASN F ND2 1 
ATOM   2989 N N   . THR A 1 420 ? 162.21783 362.33894 17.86715  1.000 39.56306  ? 455 THR F N   1 
ATOM   2990 C CA  . THR A 1 420 ? 162.24173 360.88512 17.70593  1.000 45.37452  ? 455 THR F CA  1 
ATOM   2991 C C   . THR A 1 420 ? 161.32459 360.18379 18.70426  1.000 44.49896  ? 455 THR F C   1 
ATOM   2992 O O   . THR A 1 420 ? 161.45676 360.38718 19.91434  1.000 45.01991  ? 455 THR F O   1 
ATOM   2993 C CB  . THR A 1 420 ? 163.66405 360.35185 17.87724  1.000 51.14131  ? 455 THR F CB  1 
ATOM   2994 O OG1 . THR A 1 420 ? 164.55035 361.00993 16.95844  1.000 55.93847  ? 455 THR F OG1 1 
ATOM   2995 C CG2 . THR A 1 420 ? 163.68906 358.84218 17.64079  1.000 52.85786  ? 455 THR F CG2 1 
ATOM   2996 N N   . LEU A 1 421 ? 160.52304 359.23697 18.21746  1.000 36.09871  ? 456 LEU F N   1 
ATOM   2997 C CA  . LEU A 1 421 ? 159.60264 358.49012 19.05438  1.000 45.00584  ? 456 LEU F CA  1 
ATOM   2998 C C   . LEU A 1 421 ? 159.97447 357.00985 19.06494  1.000 46.69565  ? 456 LEU F C   1 
ATOM   2999 O O   . LEU A 1 421 ? 160.20388 356.41562 18.00464  1.000 50.63419  ? 456 LEU F O   1 
ATOM   3000 C CB  . LEU A 1 421 ? 158.16377 358.68092 18.55770  1.000 36.42532  ? 456 LEU F CB  1 
ATOM   3001 C CG  . LEU A 1 421 ? 157.15115 357.96403 19.45677  1.000 51.08132  ? 456 LEU F CG  1 
ATOM   3002 C CD1 . LEU A 1 421 ? 155.93122 358.78028 19.73659  1.000 42.83310  ? 456 LEU F CD1 1 
ATOM   3003 C CD2 . LEU A 1 421 ? 156.72707 356.68490 18.74945  1.000 47.09423  ? 456 LEU F CD2 1 
ATOM   3004 N N   . TYR A 1 422 ? 160.22577 356.47608 20.26359  1.000 40.49572  ? 457 TYR F N   1 
ATOM   3005 C CA  . TYR A 1 422 ? 160.51706 355.06396 20.46588  1.000 40.21977  ? 457 TYR F CA  1 
ATOM   3006 C C   . TYR A 1 422 ? 159.31781 354.35966 21.08257  1.000 46.38360  ? 457 TYR F C   1 
ATOM   3007 O O   . TYR A 1 422 ? 158.65852 354.90765 21.98128  1.000 42.50139  ? 457 TYR F O   1 
ATOM   3008 C CB  . TYR A 1 422 ? 161.72247 354.83981 21.37501  1.000 40.51882  ? 457 TYR F CB  1 
ATOM   3009 C CG  . TYR A 1 422 ? 162.94789 355.61751 20.97629  1.000 47.48860  ? 457 TYR F CG  1 
ATOM   3010 C CD1 . TYR A 1 422 ? 163.13221 356.90440 21.49057  1.000 59.16033  ? 457 TYR F CD1 1 
ATOM   3011 C CD2 . TYR A 1 422 ? 163.86686 355.14080 20.03249  1.000 55.18922  ? 457 TYR F CD2 1 
ATOM   3012 C CE1 . TYR A 1 422 ? 164.22877 357.67687 21.16603  1.000 63.90064  ? 457 TYR F CE1 1 
ATOM   3013 C CE2 . TYR A 1 422 ? 165.00897 355.92255 19.68946  1.000 65.40599  ? 457 TYR F CE2 1 
ATOM   3014 C CZ  . TYR A 1 422 ? 165.17045 357.19022 20.26824  1.000 70.41303  ? 457 TYR F CZ  1 
ATOM   3015 O OH  . TYR A 1 422 ? 166.23954 358.02328 19.98392  1.000 77.00902  ? 457 TYR F OH  1 
ATOM   3016 N N   . CYS A 1 423 ? 159.24501 353.05749 20.83687  1.000 45.86955  ? 458 CYS F N   1 
ATOM   3017 C CA  . CYS A 1 423 ? 158.21843 352.19611 21.40882  1.000 47.36507  ? 458 CYS F CA  1 
ATOM   3018 C C   . CYS A 1 423 ? 158.84343 351.42508 22.55753  1.000 40.05599  ? 458 CYS F C   1 
ATOM   3019 O O   . CYS A 1 423 ? 159.98214 350.96821 22.47541  1.000 45.25629  ? 458 CYS F O   1 
ATOM   3020 C CB  . CYS A 1 423 ? 157.64676 351.16238 20.41296  1.000 49.69170  ? 458 CYS F CB  1 
ATOM   3021 S SG  . CYS A 1 423 ? 156.60581 351.73144 18.99356  1.000 57.37068  ? 458 CYS F SG  1 
ATOM   3022 N N   . VAL A 1 424 ? 158.12383 351.35852 23.64404  1.000 39.11630  ? 459 VAL F N   1 
ATOM   3023 C CA  . VAL A 1 424 ? 158.54058 350.68792 24.86720  1.000 44.43297  ? 459 VAL F CA  1 
ATOM   3024 C C   . VAL A 1 424 ? 158.10186 349.23493 24.77592  1.000 43.98434  ? 459 VAL F C   1 
ATOM   3025 O O   . VAL A 1 424 ? 157.00608 348.92707 24.27932  1.000 45.43509  ? 459 VAL F O   1 
ATOM   3026 C CB  . VAL A 1 424 ? 157.94684 351.37098 26.11252  1.000 43.77069  ? 459 VAL F CB  1 
ATOM   3027 C CG1 . VAL A 1 424 ? 158.45979 350.69815 27.33445  1.000 43.12224  ? 459 VAL F CG1 1 
ATOM   3028 C CG2 . VAL A 1 424 ? 158.42245 352.80236 26.17414  1.000 47.61055  ? 459 VAL F CG2 1 
ATOM   3029 N N   . ASN A 1 425 ? 158.99104 348.33085 25.17161  1.000 40.88371  ? 460 ASN F N   1 
ATOM   3030 C CA  . ASN A 1 425 ? 158.64668 346.92165 25.14211  1.000 42.68772  ? 460 ASN F CA  1 
ATOM   3031 C C   . ASN A 1 425 ? 157.56038 346.68713 26.19033  1.000 44.94011  ? 460 ASN F C   1 
ATOM   3032 O O   . ASN A 1 425 ? 157.71462 347.08117 27.34858  1.000 48.65564  ? 460 ASN F O   1 
ATOM   3033 C CB  . ASN A 1 425 ? 159.93494 346.14717 25.47736  1.000 45.99595  ? 460 ASN F CB  1 
ATOM   3034 C CG  . ASN A 1 425 ? 159.79352 344.63565 25.39561  1.000 52.09378  ? 460 ASN F CG  1 
ATOM   3035 O OD1 . ASN A 1 425 ? 158.78298 344.05228 25.78940  1.000 52.05062  ? 460 ASN F OD1 1 
ATOM   3036 N ND2 . ASN A 1 425 ? 160.84101 343.98692 24.85958  1.000 43.92449  ? 460 ASN F ND2 1 
ATOM   3037 N N   . LYS A 1 426 ? 156.44404 346.06492 25.78439  1.000 50.91857  ? 461 LYS F N   1 
ATOM   3038 C CA  . LYS A 1 426 ? 155.30286 345.83026 26.67138  1.000 53.99399  ? 461 LYS F CA  1 
ATOM   3039 C C   . LYS A 1 426 ? 155.35369 344.47965 27.38071  1.000 54.21290  ? 461 LYS F C   1 
ATOM   3040 O O   . LYS A 1 426 ? 154.31863 343.98989 27.84291  1.000 62.56929  ? 461 LYS F O   1 
ATOM   3041 C CB  . LYS A 1 426 ? 153.98832 346.00071 25.90364  1.000 52.50792  ? 461 LYS F CB  1 
ATOM   3042 C CG  . LYS A 1 426 ? 153.81633 347.34370 25.20148  1.000 56.92256  ? 461 LYS F CG  1 
ATOM   3043 C CD  . LYS A 1 426 ? 153.95966 348.53119 26.16973  1.000 59.25527  ? 461 LYS F CD  1 
ATOM   3044 C CE  . LYS A 1 426 ? 152.81955 348.49319 27.20784  1.000 59.18799  ? 461 LYS F CE  1 
ATOM   3045 N NZ  . LYS A 1 426 ? 152.86886 349.56860 28.23420  1.000 48.13117  ? 461 LYS F NZ  1 
ATOM   3046 N N   . GLN A 1 427 ? 156.54413 343.96281 27.61259  1.000 50.81836  ? 462 GLN F N   1 
ATOM   3047 C CA  . GLN A 1 427 ? 156.77845 342.69228 28.28963  1.000 56.35798  ? 462 GLN F CA  1 
ATOM   3048 C C   . GLN A 1 427 ? 156.50299 342.80899 29.77414  1.000 54.55623  ? 462 GLN F C   1 
ATOM   3049 O O   . GLN A 1 427 ? 156.77981 343.84287 30.38144  1.000 54.76264  ? 462 GLN F O   1 
ATOM   3050 C CB  . GLN A 1 427 ? 158.24495 342.33029 28.16018  1.000 59.83666  ? 462 GLN F CB  1 
ATOM   3051 C CG  . GLN A 1 427 ? 158.62529 341.01589 27.64058  1.000 64.52422  ? 462 GLN F CG  1 
ATOM   3052 C CD  . GLN A 1 427 ? 160.12988 340.93025 27.70178  1.000 65.05011  ? 462 GLN F CD  1 
ATOM   3053 O OE1 . GLN A 1 427 ? 160.81369 341.96511 27.59192  1.000 57.89407  ? 462 GLN F OE1 1 
ATOM   3054 N NE2 . GLN A 1 427 ? 160.66127 339.72792 27.93259  1.000 67.11126  ? 462 GLN F NE2 1 
ATOM   3055 N N   . GLU A 1 428 ? 155.92773 341.77064 30.36019  1.000 60.33302  ? 463 GLU F N   1 
ATOM   3056 C CA  . GLU A 1 428 ? 155.64982 341.80660 31.79144  1.000 63.74489  ? 463 GLU F CA  1 
ATOM   3057 C C   . GLU A 1 428 ? 156.88355 341.52281 32.64363  1.000 57.98063  ? 463 GLU F C   1 
ATOM   3058 O O   . GLU A 1 428 ? 157.71238 340.67017 32.30825  1.000 56.55315  ? 463 GLU F O   1 
ATOM   3059 C CB  . GLU A 1 428 ? 154.56172 340.81353 32.16418  1.000 70.18440  ? 463 GLU F CB  1 
ATOM   3060 C CG  . GLU A 1 428 ? 153.63591 341.39489 33.21107  1.000 78.21042  ? 463 GLU F CG  1 
ATOM   3061 C CD  . GLU A 1 428 ? 152.22317 340.94189 33.00411  1.000 96.66346  ? 463 GLU F CD  1 
ATOM   3062 O OE1 . GLU A 1 428 ? 152.03981 339.77549 32.57539  1.000 95.94935  ? 463 GLU F OE1 1 
ATOM   3063 O OE2 . GLU A 1 428 ? 151.30578 341.76412 33.23918  1.000 105.39814 ? 463 GLU F OE2 1 
ATOM   3064 N N   . GLY A 1 429 ? 157.03169 342.30618 33.70656  1.000 54.47969  ? 464 GLY F N   1 
ATOM   3065 C CA  . GLY A 1 429 ? 158.13468 342.17694 34.64084  1.000 47.56447  ? 464 GLY F CA  1 
ATOM   3066 C C   . GLY A 1 429 ? 158.09689 343.33539 35.61008  1.000 53.43190  ? 464 GLY F C   1 
ATOM   3067 O O   . GLY A 1 429 ? 157.30323 344.26514 35.47066  1.000 65.48023  ? 464 GLY F O   1 
ATOM   3068 N N   . GLN A 1 430 ? 158.96839 343.27097 36.60971  1.000 54.31156  ? 465 GLN F N   1 
ATOM   3069 C CA  . GLN A 1 430 ? 159.04110 344.29431 37.65050  1.000 57.44316  ? 465 GLN F CA  1 
ATOM   3070 C C   . GLN A 1 430 ? 160.30294 345.15590 37.53319  1.000 54.73565  ? 465 GLN F C   1 
ATOM   3071 O O   . GLN A 1 430 ? 161.42189 344.62592 37.43873  1.000 51.69434  ? 465 GLN F O   1 
ATOM   3072 C CB  . GLN A 1 430 ? 158.94738 343.67764 39.04850  1.000 57.04851  ? 465 GLN F CB  1 
ATOM   3073 C CG  . GLN A 1 430 ? 157.90822 344.41496 39.94395  1.000 79.84807  ? 465 GLN F CG  1 
ATOM   3074 C CD  . GLN A 1 430 ? 156.55039 344.64654 39.23716  1.000 83.16288  ? 465 GLN F CD  1 
ATOM   3075 O OE1 . GLN A 1 430 ? 155.93094 343.69922 38.72094  1.000 79.42032  ? 465 GLN F OE1 1 
ATOM   3076 N NE2 . GLN A 1 430 ? 156.08824 345.90887 39.21866  1.000 75.88376  ? 465 GLN F NE2 1 
ATOM   3077 N N   . SER A 1 431 ? 160.12264 346.47514 37.54682  1.000 48.96729  ? 466 SER F N   1 
ATOM   3078 C CA  . SER A 1 431 ? 161.22712 347.42286 37.54648  1.000 48.95305  ? 466 SER F CA  1 
ATOM   3079 C C   . SER A 1 431 ? 161.44810 348.01096 38.93457  1.000 50.66447  ? 466 SER F C   1 
ATOM   3080 O O   . SER A 1 431 ? 160.50371 348.28774 39.67310  1.000 54.54512  ? 466 SER F O   1 
ATOM   3081 C CB  . SER A 1 431 ? 160.98699 348.56828 36.57060  1.000 51.68393  ? 466 SER F CB  1 
ATOM   3082 O OG  . SER A 1 431 ? 160.86000 348.10183 35.24005  1.000 57.31823  ? 466 SER F OG  1 
ATOM   3083 N N   . LEU A 1 432 ? 162.70740 348.30603 39.22346  1.000 51.09838  ? 467 LEU F N   1 
ATOM   3084 C CA  . LEU A 1 432 ? 163.15687 348.88373 40.48393  1.000 52.46892  ? 467 LEU F CA  1 
ATOM   3085 C C   . LEU A 1 432 ? 164.02117 350.10267 40.18789  1.000 53.80348  ? 467 LEU F C   1 
ATOM   3086 O O   . LEU A 1 432 ? 165.02044 350.00428 39.46576  1.000 50.56491  ? 467 LEU F O   1 
ATOM   3087 C CB  . LEU A 1 432 ? 163.95060 347.87831 41.32973  1.000 46.92564  ? 467 LEU F CB  1 
ATOM   3088 C CG  . LEU A 1 432 ? 164.41113 348.51540 42.65860  1.000 55.11422  ? 467 LEU F CG  1 
ATOM   3089 C CD1 . LEU A 1 432 ? 163.24813 349.06894 43.52245  1.000 56.49955  ? 467 LEU F CD1 1 
ATOM   3090 C CD2 . LEU A 1 432 ? 165.34037 347.61870 43.47255  1.000 50.31729  ? 467 LEU F CD2 1 
ATOM   3091 N N   . TYR A 1 433 ? 163.61517 351.25800 40.70098  1.000 53.11238  ? 468 TYR F N   1 
ATOM   3092 C CA  . TYR A 1 433 ? 164.36025 352.49747 40.50671  1.000 44.96361  ? 468 TYR F CA  1 
ATOM   3093 C C   . TYR A 1 433 ? 165.30691 352.61545 41.69602  1.000 50.93693  ? 468 TYR F C   1 
ATOM   3094 O O   . TYR A 1 433 ? 164.86013 352.80243 42.83345  1.000 55.83296  ? 468 TYR F O   1 
ATOM   3095 C CB  . TYR A 1 433 ? 163.43044 353.69534 40.48789  1.000 44.09736  ? 468 TYR F CB  1 
ATOM   3096 C CG  . TYR A 1 433 ? 164.01509 354.95001 39.88751  1.000 46.14547  ? 468 TYR F CG  1 
ATOM   3097 C CD1 . TYR A 1 433 ? 164.96823 355.68600 40.57624  1.000 45.47987  ? 468 TYR F CD1 1 
ATOM   3098 C CD2 . TYR A 1 433 ? 163.49197 355.49034 38.70522  1.000 40.21811  ? 468 TYR F CD2 1 
ATOM   3099 C CE1 . TYR A 1 433 ? 165.48769 356.87052 40.04834  1.000 43.88498  ? 468 TYR F CE1 1 
ATOM   3100 C CE2 . TYR A 1 433 ? 163.98518 356.68912 38.17750  1.000 41.68242  ? 468 TYR F CE2 1 
ATOM   3101 C CZ  . TYR A 1 433 ? 164.98358 357.37174 38.85396  1.000 43.07728  ? 468 TYR F CZ  1 
ATOM   3102 O OH  . TYR A 1 433 ? 165.49590 358.55202 38.33013  1.000 44.65541  ? 468 TYR F OH  1 
ATOM   3103 N N   . VAL A 1 434 ? 166.60591 352.43649 41.46180  1.000 49.78484  ? 469 VAL F N   1 
ATOM   3104 C CA  . VAL A 1 434 ? 167.59806 352.51238 42.53379  1.000 47.40044  ? 469 VAL F CA  1 
ATOM   3105 C C   . VAL A 1 434 ? 168.09477 353.95224 42.58514  1.000 56.30415  ? 469 VAL F C   1 
ATOM   3106 O O   . VAL A 1 434 ? 169.03223 354.33732 41.86521  1.000 48.33300  ? 469 VAL F O   1 
ATOM   3107 C CB  . VAL A 1 434 ? 168.74639 351.53000 42.33453  1.000 51.46756  ? 469 VAL F CB  1 
ATOM   3108 C CG1 . VAL A 1 434 ? 169.75741 351.68422 43.48639  1.000 42.91902  ? 469 VAL F CG1 1 
ATOM   3109 C CG2 . VAL A 1 434 ? 168.21727 350.09365 42.21845  1.000 44.39725  ? 469 VAL F CG2 1 
ATOM   3110 N N   . LYS A 1 435 ? 167.53714 354.71475 43.52660  1.000 56.46585  ? 470 LYS F N   1 
ATOM   3111 C CA  . LYS A 1 435 ? 167.85620 356.12601 43.66281  1.000 52.35527  ? 470 LYS F CA  1 
ATOM   3112 C C   . LYS A 1 435 ? 169.29100 356.26507 44.12677  1.000 51.65528  ? 470 LYS F C   1 
ATOM   3113 O O   . LYS A 1 435 ? 169.83917 355.38577 44.79918  1.000 45.53377  ? 470 LYS F O   1 
ATOM   3114 C CB  . LYS A 1 435 ? 166.89269 356.75793 44.67261  1.000 58.40896  ? 470 LYS F CB  1 
ATOM   3115 C CG  . LYS A 1 435 ? 165.70242 357.46784 44.04122  1.000 62.63239  ? 470 LYS F CG  1 
ATOM   3116 C CD  . LYS A 1 435 ? 164.63809 357.78923 45.06964  1.000 70.54732  ? 470 LYS F CD  1 
ATOM   3117 C CE  . LYS A 1 435 ? 164.08123 356.46055 45.63586  1.000 79.47705  ? 470 LYS F CE  1 
ATOM   3118 N NZ  . LYS A 1 435 ? 162.59265 356.43629 45.89428  1.000 83.21130  ? 470 LYS F NZ  1 
ATOM   3119 N N   . GLY A 1 436 ? 169.92275 357.35029 43.68516  1.000 50.87543  ? 471 GLY F N   1 
ATOM   3120 C CA  . GLY A 1 436 ? 171.29847 357.60965 44.03483  1.000 43.35695  ? 471 GLY F CA  1 
ATOM   3121 C C   . GLY A 1 436 ? 171.82690 358.86220 43.37535  1.000 47.78613  ? 471 GLY F C   1 
ATOM   3122 O O   . GLY A 1 436 ? 171.29926 359.30713 42.35190  1.000 53.85612  ? 471 GLY F O   1 
ATOM   3123 N N   . GLU A 1 437 ? 172.81208 359.48034 43.99089  1.000 50.45634  ? 472 GLU F N   1 
ATOM   3124 C CA  . GLU A 1 437 ? 173.41148 360.69211 43.43441  1.000 55.40097  ? 472 GLU F CA  1 
ATOM   3125 C C   . GLU A 1 437 ? 174.18224 360.40751 42.14393  1.000 51.95497  ? 472 GLU F C   1 
ATOM   3126 O O   . GLU A 1 437 ? 175.07213 359.54981 42.14443  1.000 51.15926  ? 472 GLU F O   1 
ATOM   3127 C CB  . GLU A 1 437 ? 174.32670 361.34176 44.46028  1.000 48.02201  ? 472 GLU F CB  1 
ATOM   3128 C CG  . GLU A 1 437 ? 175.02509 362.51832 43.86529  1.000 61.99693  ? 472 GLU F CG  1 
ATOM   3129 C CD  . GLU A 1 437 ? 174.22104 363.78524 43.93910  1.000 72.52003  ? 472 GLU F CD  1 
ATOM   3130 O OE1 . GLU A 1 437 ? 173.19392 363.80747 44.66379  1.000 74.19656  ? 472 GLU F OE1 1 
ATOM   3131 O OE2 . GLU A 1 437 ? 174.60477 364.74505 43.22030  1.000 73.19250  ? 472 GLU F OE2 1 
ATOM   3132 N N   . PRO A 1 438 ? 173.94494 361.15281 41.06186  1.000 51.43185  ? 473 PRO F N   1 
ATOM   3133 C CA  . PRO A 1 438 ? 174.73938 360.92868 39.84684  1.000 49.90662  ? 473 PRO F CA  1 
ATOM   3134 C C   . PRO A 1 438 ? 176.21871 361.15740 40.10351  1.000 58.48988  ? 473 PRO F C   1 
ATOM   3135 O O   . PRO A 1 438 ? 176.64263 362.25595 40.48363  1.000 60.95994  ? 473 PRO F O   1 
ATOM   3136 C CB  . PRO A 1 438 ? 174.18234 361.97559 38.87156  1.000 47.44448  ? 473 PRO F CB  1 
ATOM   3137 C CG  . PRO A 1 438 ? 172.82557 362.26678 39.37270  1.000 46.92110  ? 473 PRO F CG  1 
ATOM   3138 C CD  . PRO A 1 438 ? 172.90418 362.17092 40.85325  1.000 53.71593  ? 473 PRO F CD  1 
ATOM   3139 N N   . ILE A 1 439 ? 177.02474 360.14100 39.78158  1.000 52.44462  ? 474 ILE F N   1 
ATOM   3140 C CA  . ILE A 1 439 ? 178.43879 360.21802 40.11083  1.000 47.67617  ? 474 ILE F CA  1 
ATOM   3141 C C   . ILE A 1 439 ? 179.16489 361.29285 39.33232  1.000 51.16752  ? 474 ILE F C   1 
ATOM   3142 O O   . ILE A 1 439 ? 180.26374 361.68648 39.73013  1.000 57.77928  ? 474 ILE F O   1 
ATOM   3143 C CB  . ILE A 1 439 ? 179.19976 358.89412 39.91704  1.000 54.30339  ? 474 ILE F CB  1 
ATOM   3144 C CG1 . ILE A 1 439 ? 179.34577 358.51632 38.44856  1.000 45.12855  ? 474 ILE F CG1 1 
ATOM   3145 C CG2 . ILE A 1 439 ? 178.48315 357.77745 40.66840  1.000 46.65564  ? 474 ILE F CG2 1 
ATOM   3146 C CD1 . ILE A 1 439 ? 180.17624 357.22802 38.28114  1.000 41.09329  ? 474 ILE F CD1 1 
ATOM   3147 N N   . ILE A 1 440 ? 178.56612 361.83746 38.27513  1.000 48.48185  ? 475 ILE F N   1 
ATOM   3148 C CA  . ILE A 1 440 ? 179.25862 362.88993 37.54102  1.000 49.16489  ? 475 ILE F CA  1 
ATOM   3149 C C   . ILE A 1 440 ? 179.41269 364.14469 38.40179  1.000 52.72492  ? 475 ILE F C   1 
ATOM   3150 O O   . ILE A 1 440 ? 180.30555 364.95878 38.14312  1.000 52.95448  ? 475 ILE F O   1 
ATOM   3151 C CB  . ILE A 1 440 ? 178.48530 363.22291 36.25052  1.000 47.10246  ? 475 ILE F CB  1 
ATOM   3152 C CG1 . ILE A 1 440 ? 179.32591 364.07832 35.28090  1.000 45.45812  ? 475 ILE F CG1 1 
ATOM   3153 C CG2 . ILE A 1 440 ? 177.18189 363.92416 36.61131  1.000 46.36896  ? 475 ILE F CG2 1 
ATOM   3154 C CD1 . ILE A 1 440 ? 180.59103 363.39186 34.80501  1.000 48.92349  ? 475 ILE F CD1 1 
ATOM   3155 N N   . ASN A 1 441 ? 178.58756 364.29708 39.44040  1.000 50.77248  ? 476 ASN F N   1 
ATOM   3156 C CA  . ASN A 1 441 ? 178.65734 365.43769 40.34370  1.000 60.91507  ? 476 ASN F CA  1 
ATOM   3157 C C   . ASN A 1 441 ? 179.82426 365.36651 41.31998  1.000 62.13092  ? 476 ASN F C   1 
ATOM   3158 O O   . ASN A 1 441 ? 180.05340 366.33692 42.04716  1.000 62.22642  ? 476 ASN F O   1 
ATOM   3159 C CB  . ASN A 1 441 ? 177.37229 365.57701 41.17378  1.000 54.66052  ? 476 ASN F CB  1 
ATOM   3160 C CG  . ASN A 1 441 ? 176.14703 365.80382 40.33514  1.000 51.47662  ? 476 ASN F CG  1 
ATOM   3161 O OD1 . ASN A 1 441 ? 176.22099 366.31194 39.21107  1.000 55.53661  ? 476 ASN F OD1 1 
ATOM   3162 N ND2 . ASN A 1 441 ? 174.99449 365.56198 40.93356  1.000 53.67756  ? 476 ASN F ND2 1 
ATOM   3163 N N   . PHE A 1 442 ? 180.49889 364.22954 41.42376  1.000 61.63667  ? 477 PHE F N   1 
ATOM   3164 C CA  . PHE A 1 442 ? 181.65207 364.08477 42.29942  1.000 58.76603  ? 477 PHE F CA  1 
ATOM   3165 C C   . PHE A 1 442 ? 182.94823 364.54973 41.64781  1.000 60.03004  ? 477 PHE F C   1 
ATOM   3166 O O   . PHE A 1 442 ? 184.01577 364.34885 42.23709  1.000 70.51591  ? 477 PHE F O   1 
ATOM   3167 C CB  . PHE A 1 442 ? 181.79871 362.62640 42.72008  1.000 59.29756  ? 477 PHE F CB  1 
ATOM   3168 C CG  . PHE A 1 442 ? 180.61604 362.08976 43.44929  1.000 62.56101  ? 477 PHE F CG  1 
ATOM   3169 C CD1 . PHE A 1 442 ? 179.85133 362.91319 44.25488  1.000 64.61801  ? 477 PHE F CD1 1 
ATOM   3170 C CD2 . PHE A 1 442 ? 180.23735 360.76685 43.28832  1.000 59.63775  ? 477 PHE F CD2 1 
ATOM   3171 C CE1 . PHE A 1 442 ? 178.74504 362.41813 44.92436  1.000 63.02772  ? 477 PHE F CE1 1 
ATOM   3172 C CE2 . PHE A 1 442 ? 179.13867 360.25813 43.94892  1.000 59.48407  ? 477 PHE F CE2 1 
ATOM   3173 C CZ  . PHE A 1 442 ? 178.38543 361.08390 44.76700  1.000 67.08156  ? 477 PHE F CZ  1 
ATOM   3174 N N   . TYR A 1 443 ? 182.89423 365.11156 40.44076  1.000 63.32802  ? 478 TYR F N   1 
ATOM   3175 C CA  . TYR A 1 443 ? 184.09192 365.44213 39.67597  1.000 64.23062  ? 478 TYR F CA  1 
ATOM   3176 C C   . TYR A 1 443 ? 184.25029 366.94539 39.47531  1.000 65.61103  ? 478 TYR F C   1 
ATOM   3177 O O   . TYR A 1 443 ? 183.29077 367.62798 39.10154  1.000 67.84091  ? 478 TYR F O   1 
ATOM   3178 C CB  . TYR A 1 443 ? 184.02796 364.74846 38.31475  1.000 59.63666  ? 478 TYR F CB  1 
ATOM   3179 C CG  . TYR A 1 443 ? 184.26063 363.26540 38.41761  1.000 59.84472  ? 478 TYR F CG  1 
ATOM   3180 C CD1 . TYR A 1 443 ? 185.53557 362.74277 38.50707  1.000 57.30640  ? 478 TYR F CD1 1 
ATOM   3181 C CD2 . TYR A 1 443 ? 183.17977 362.38297 38.45057  1.000 56.28130  ? 478 TYR F CD2 1 
ATOM   3182 C CE1 . TYR A 1 443 ? 185.73593 361.38099 38.61468  1.000 61.01828  ? 478 TYR F CE1 1 
ATOM   3183 C CE2 . TYR A 1 443 ? 183.36339 361.01754 38.55906  1.000 51.63384  ? 478 TYR F CE2 1 
ATOM   3184 C CZ  . TYR A 1 443 ? 184.64255 360.51358 38.64039  1.000 59.72768  ? 478 TYR F CZ  1 
ATOM   3185 O OH  . TYR A 1 443 ? 184.83689 359.14222 38.74542  1.000 57.73467  ? 478 TYR F OH  1 
ATOM   3186 N N   . ASP A 1 444 ? 185.44816 367.46749 39.74625  1.000 68.28193  ? 479 ASP F N   1 
ATOM   3187 C CA  . ASP A 1 444 ? 185.68279 368.87670 39.45370  1.000 72.72385  ? 479 ASP F CA  1 
ATOM   3188 C C   . ASP A 1 444 ? 185.86141 369.06263 37.95046  1.000 70.87825  ? 479 ASP F C   1 
ATOM   3189 O O   . ASP A 1 444 ? 186.75027 368.43710 37.36115  1.000 72.89298  ? 479 ASP F O   1 
ATOM   3190 C CB  . ASP A 1 444 ? 186.90427 369.43370 40.17502  1.000 79.66032  ? 479 ASP F CB  1 
ATOM   3191 C CG  . ASP A 1 444 ? 187.14832 370.90554 39.82177  1.000 78.40703  ? 479 ASP F CG  1 
ATOM   3192 O OD1 . ASP A 1 444 ? 186.44579 371.77769 40.37629  1.000 84.98232  ? 479 ASP F OD1 1 
ATOM   3193 O OD2 . ASP A 1 444 ? 187.99350 371.19578 38.95240  1.000 81.22253  ? 479 ASP F OD2 1 
ATOM   3194 N N   . PRO A 1 445 ? 185.11081 369.96742 37.32167  1.000 68.32509  ? 480 PRO F N   1 
ATOM   3195 C CA  . PRO A 1 445 ? 185.20813 370.11061 35.85986  1.000 67.04824  ? 480 PRO F CA  1 
ATOM   3196 C C   . PRO A 1 445 ? 186.58177 370.53429 35.36872  1.000 75.78818  ? 480 PRO F C   1 
ATOM   3197 O O   . PRO A 1 445 ? 186.96155 370.15265 34.25248  1.000 73.93490  ? 480 PRO F O   1 
ATOM   3198 C CB  . PRO A 1 445 ? 184.14786 371.17290 35.55647  1.000 64.67393  ? 480 PRO F CB  1 
ATOM   3199 C CG  . PRO A 1 445 ? 183.13062 371.02798 36.67697  1.000 63.35467  ? 480 PRO F CG  1 
ATOM   3200 C CD  . PRO A 1 445 ? 183.72885 370.16585 37.77747  1.000 63.97263  ? 480 PRO F CD  1 
ATOM   3201 N N   . LEU A 1 446 ? 187.28528 371.41158 36.09134  1.000 80.06437  ? 481 LEU F N   1 
ATOM   3202 C CA  . LEU A 1 446 ? 188.55207 371.93094 35.57344  1.000 82.54569  ? 481 LEU F CA  1 
ATOM   3203 C C   . LEU A 1 446 ? 189.56607 370.81439 35.33135  1.000 80.67041  ? 481 LEU F C   1 
ATOM   3204 O O   . LEU A 1 446 ? 190.32195 370.86720 34.35509  1.000 82.17217  ? 481 LEU F O   1 
ATOM   3205 C CB  . LEU A 1 446 ? 189.11654 373.04104 36.47152  1.000 82.02645  ? 481 LEU F CB  1 
ATOM   3206 C CG  . LEU A 1 446 ? 188.19795 374.25586 36.67762  1.000 79.04665  ? 481 LEU F CG  1 
ATOM   3207 C CD1 . LEU A 1 446 ? 187.44635 374.56083 35.36920  1.000 82.76385  ? 481 LEU F CD1 1 
ATOM   3208 C CD2 . LEU A 1 446 ? 187.21692 374.08169 37.82192  1.000 84.84176  ? 481 LEU F CD2 1 
ATOM   3209 N N   . VAL A 1 447 ? 189.64639 369.82222 36.22043  1.000 82.74298  ? 482 VAL F N   1 
ATOM   3210 C CA  . VAL A 1 447 ? 190.66540 368.78396 36.07012  1.000 81.63989  ? 482 VAL F CA  1 
ATOM   3211 C C   . VAL A 1 447 ? 190.08981 367.47643 35.49721  1.000 82.49689  ? 482 VAL F C   1 
ATOM   3212 O O   . VAL A 1 447 ? 190.79090 366.45707 35.47602  1.000 85.39362  ? 482 VAL F O   1 
ATOM   3213 C CB  . VAL A 1 447 ? 191.38810 368.52850 37.40791  1.000 82.67697  ? 482 VAL F CB  1 
ATOM   3214 C CG1 . VAL A 1 447 ? 192.15842 369.76041 37.84201  1.000 87.17064  ? 482 VAL F CG1 1 
ATOM   3215 C CG2 . VAL A 1 447 ? 190.40161 368.15196 38.49518  1.000 78.64993  ? 482 VAL F CG2 1 
ATOM   3216 N N   . PHE A 1 448 ? 188.84073 367.48644 35.00198  1.000 76.14903  ? 483 PHE F N   1 
ATOM   3217 C CA  . PHE A 1 448 ? 188.22105 366.25881 34.49621  1.000 67.23984  ? 483 PHE F CA  1 
ATOM   3218 C C   . PHE A 1 448 ? 188.92868 365.82995 33.20406  1.000 64.98166  ? 483 PHE F C   1 
ATOM   3219 O O   . PHE A 1 448 ? 189.06338 366.64242 32.28138  1.000 65.93748  ? 483 PHE F O   1 
ATOM   3220 C CB  . PHE A 1 448 ? 186.74560 366.52935 34.19788  1.000 67.93346  ? 483 PHE F CB  1 
ATOM   3221 C CG  . PHE A 1 448 ? 185.90879 365.29836 33.96403  1.000 55.63013  ? 483 PHE F CG  1 
ATOM   3222 C CD1 . PHE A 1 448 ? 185.75184 364.35473 34.97185  1.000 59.57630  ? 483 PHE F CD1 1 
ATOM   3223 C CD2 . PHE A 1 448 ? 185.36405 365.04580 32.72620  1.000 52.60998  ? 483 PHE F CD2 1 
ATOM   3224 C CE1 . PHE A 1 448 ? 184.99135 363.22701 34.78124  1.000 55.79628  ? 483 PHE F CE1 1 
ATOM   3225 C CE2 . PHE A 1 448 ? 184.61483 363.89841 32.50572  1.000 59.79724  ? 483 PHE F CE2 1 
ATOM   3226 C CZ  . PHE A 1 448 ? 184.42376 362.98467 33.53953  1.000 52.30302  ? 483 PHE F CZ  1 
ATOM   3227 N N   . PRO A 1 449 ? 189.20961 364.53478 33.01411  1.000 60.63754  ? 484 PRO F N   1 
ATOM   3228 C CA  . PRO A 1 449 ? 189.68800 364.07004 31.69454  1.000 57.95267  ? 484 PRO F CA  1 
ATOM   3229 C C   . PRO A 1 449 ? 188.54409 363.85884 30.72093  1.000 57.89872  ? 484 PRO F C   1 
ATOM   3230 O O   . PRO A 1 449 ? 187.87810 362.83056 30.82854  1.000 58.20046  ? 484 PRO F O   1 
ATOM   3231 C CB  . PRO A 1 449 ? 190.35469 362.73060 32.00833  1.000 56.33487  ? 484 PRO F CB  1 
ATOM   3232 C CG  . PRO A 1 449 ? 190.40536 362.64364 33.51192  1.000 65.69397  ? 484 PRO F CG  1 
ATOM   3233 C CD  . PRO A 1 449 ? 189.28985 363.47703 34.02730  1.000 62.84687  ? 484 PRO F CD  1 
ATOM   3234 N N   . SER A 1 450 ? 188.31746 364.74660 29.75489  1.000 57.73206  ? 485 SER F N   1 
ATOM   3235 C CA  . SER A 1 450 ? 187.13374 364.65243 28.90850  1.000 56.64687  ? 485 SER F CA  1 
ATOM   3236 C C   . SER A 1 450 ? 187.38626 363.95468 27.57354  1.000 58.96705  ? 485 SER F C   1 
ATOM   3237 O O   . SER A 1 450 ? 186.52429 363.97513 26.68611  1.000 60.34444  ? 485 SER F O   1 
ATOM   3238 C CB  . SER A 1 450 ? 186.57527 366.05141 28.65181  1.000 57.85836  ? 485 SER F CB  1 
ATOM   3239 O OG  . SER A 1 450 ? 187.54308 366.85047 27.96922  1.000 68.37753  ? 485 SER F OG  1 
ATOM   3240 N N   . ASN A 1 451 ? 188.54056 363.36458 27.38121  1.000 62.62620  ? 486 ASN F N   1 
ATOM   3241 C CA  . ASN A 1 451 ? 188.82146 362.74792 26.09294  1.000 58.61930  ? 486 ASN F CA  1 
ATOM   3242 C C   . ASN A 1 451 ? 188.98795 361.23822 26.21750  1.000 60.38437  ? 486 ASN F C   1 
ATOM   3243 O O   . ASN A 1 451 ? 189.70796 360.62914 25.42871  1.000 61.67804  ? 486 ASN F O   1 
ATOM   3244 C CB  . ASN A 1 451 ? 190.07804 363.36553 25.48099  1.000 60.80242  ? 486 ASN F CB  1 
ATOM   3245 C CG  . ASN A 1 451 ? 190.17762 363.11281 23.99699  1.000 68.07085  ? 486 ASN F CG  1 
ATOM   3246 O OD1 . ASN A 1 451 ? 189.16611 363.07193 23.27874  1.000 70.29541  ? 486 ASN F OD1 1 
ATOM   3247 N ND2 . ASN A 1 451 ? 191.39921 362.92545 23.52155  1.000 69.49977  ? 486 ASN F ND2 1 
ATOM   3248 N N   . GLN A 1 452 ? 188.37503 360.61691 27.22032  1.000 55.70371  ? 487 GLN F N   1 
ATOM   3249 C CA  . GLN A 1 452 ? 188.70806 359.23554 27.54701  1.000 57.39986  ? 487 GLN F CA  1 
ATOM   3250 C C   . GLN A 1 452 ? 187.74921 358.25694 26.88957  1.000 57.48065  ? 487 GLN F C   1 
ATOM   3251 O O   . GLN A 1 452 ? 186.53433 358.46001 26.86637  1.000 64.85331  ? 487 GLN F O   1 
ATOM   3252 C CB  . GLN A 1 452 ? 188.72943 359.00357 29.05525  1.000 48.79137  ? 487 GLN F CB  1 
ATOM   3253 C CG  . GLN A 1 452 ? 189.79635 359.79799 29.75315  1.000 52.74161  ? 487 GLN F CG  1 
ATOM   3254 C CD  . GLN A 1 452 ? 191.18451 359.39494 29.30671  1.000 59.61987  ? 487 GLN F CD  1 
ATOM   3255 O OE1 . GLN A 1 452 ? 191.50348 358.20047 29.23637  1.000 61.97217  ? 487 GLN F OE1 1 
ATOM   3256 N NE2 . GLN A 1 452 ? 192.02388 360.38625 29.01191  1.000 50.40985  ? 487 GLN F NE2 1 
ATOM   3257 N N   . PHE A 1 453 ? 188.31647 357.16434 26.40627  1.000 64.51890  ? 488 PHE F N   1 
ATOM   3258 C CA  . PHE A 1 453 ? 187.59811 356.15810 25.63093  1.000 69.56796  ? 488 PHE F CA  1 
ATOM   3259 C C   . PHE A 1 453 ? 187.49714 354.85270 26.39884  1.000 67.48413  ? 488 PHE F C   1 
ATOM   3260 O O   . PHE A 1 453 ? 186.39169 354.46342 26.76522  1.000 72.91744  ? 488 PHE F O   1 
ATOM   3261 C CB  . PHE A 1 453 ? 188.16808 356.06938 24.23025  1.000 73.76673  ? 488 PHE F CB  1 
ATOM   3262 C CG  . PHE A 1 453 ? 187.63553 357.16957 23.40769  1.000 83.27794  ? 488 PHE F CG  1 
ATOM   3263 C CD1 . PHE A 1 453 ? 186.27255 357.20683 23.11978  1.000 87.35196  ? 488 PHE F CD1 1 
ATOM   3264 C CD2 . PHE A 1 453 ? 188.41465 358.27403 23.10563  1.000 87.49428  ? 488 PHE F CD2 1 
ATOM   3265 C CE1 . PHE A 1 453 ? 185.71409 358.27323 22.42788  1.000 86.24792  ? 488 PHE F CE1 1 
ATOM   3266 C CE2 . PHE A 1 453 ? 187.87170 359.35384 22.40464  1.000 91.02130  ? 488 PHE F CE2 1 
ATOM   3267 C CZ  . PHE A 1 453 ? 186.51519 359.35185 22.06725  1.000 95.83104  ? 488 PHE F CZ  1 
ATOM   3268 N N   . ASP A 1 454 ? 188.56153 354.09871 26.53479  1.000 70.00292  ? 489 ASP F N   1 
ATOM   3269 C CA  . ASP A 1 454 ? 188.45988 352.83406 27.24179  1.000 68.16644  ? 489 ASP F CA  1 
ATOM   3270 C C   . ASP A 1 454 ? 189.07032 352.97516 28.63256  1.000 69.70961  ? 489 ASP F C   1 
ATOM   3271 O O   . ASP A 1 454 ? 190.04780 352.32162 28.98832  1.000 83.13793  ? 489 ASP F O   1 
ATOM   3272 C CB  . ASP A 1 454 ? 189.17532 351.75386 26.44125  1.000 79.79312  ? 489 ASP F CB  1 
ATOM   3273 C CG  . ASP A 1 454 ? 188.57840 350.38835 26.63203  1.000 83.22888  ? 489 ASP F CG  1 
ATOM   3274 O OD1 . ASP A 1 454 ? 187.75157 350.22777 27.55577  1.000 86.39772  ? 489 ASP F OD1 1 
ATOM   3275 O OD2 . ASP A 1 454 ? 188.96516 349.47030 25.87043  1.000 87.74247  ? 489 ASP F OD2 1 
ATOM   3276 N N   . ALA A 1 455 ? 188.52589 353.92900 29.38649  1.000 58.37479  ? 490 ALA F N   1 
ATOM   3277 C CA  . ALA A 1 455 ? 189.07077 354.28150 30.68810  1.000 64.38970  ? 490 ALA F CA  1 
ATOM   3278 C C   . ALA A 1 455 ? 188.26514 353.71171 31.86289  1.000 65.04426  ? 490 ALA F C   1 
ATOM   3279 O O   . ALA A 1 455 ? 187.08865 353.38632 31.73715  1.000 73.66692  ? 490 ALA F O   1 
ATOM   3280 C CB  . ALA A 1 455 ? 189.17754 355.79880 30.81063  1.000 60.27735  ? 490 ALA F CB  1 
ATOM   3281 N N   . SER A 1 456 ? 188.97628 353.39103 32.92612  1.000 69.03772  ? 491 SER F N   1 
ATOM   3282 C CA  . SER A 1 456 ? 188.52677 352.91503 34.22700  1.000 68.25217  ? 491 SER F CA  1 
ATOM   3283 C C   . SER A 1 456 ? 188.17247 354.04010 35.20105  1.000 68.49299  ? 491 SER F C   1 
ATOM   3284 O O   . SER A 1 456 ? 188.60128 355.18520 35.05014  1.000 70.93663  ? 491 SER F O   1 
ATOM   3285 C CB  . SER A 1 456 ? 189.58230 352.02649 34.85037  1.000 69.37874  ? 491 SER F CB  1 
ATOM   3286 O OG  . SER A 1 456 ? 190.83101 352.67423 34.85423  1.000 75.01693  ? 491 SER F OG  1 
ATOM   3287 N N   . ILE A 1 457 ? 187.36779 353.70288 36.20801  1.000 62.32460  ? 492 ILE F N   1 
ATOM   3288 C CA  . ILE A 1 457 ? 187.05314 354.68913 37.23610  1.000 62.04414  ? 492 ILE F CA  1 
ATOM   3289 C C   . ILE A 1 457 ? 188.34860 355.11329 37.92650  1.000 73.04681  ? 492 ILE F C   1 
ATOM   3290 O O   . ILE A 1 457 ? 188.59915 356.30420 38.15994  1.000 72.04847  ? 492 ILE F O   1 
ATOM   3291 C CB  . ILE A 1 457 ? 186.07442 354.09623 38.26793  1.000 59.67399  ? 492 ILE F CB  1 
ATOM   3292 C CG1 . ILE A 1 457 ? 184.62904 354.19945 37.81916  1.000 59.14526  ? 492 ILE F CG1 1 
ATOM   3293 C CG2 . ILE A 1 457 ? 186.24238 354.77173 39.61012  1.000 60.88379  ? 492 ILE F CG2 1 
ATOM   3294 C CD1 . ILE A 1 457 ? 184.17476 355.62090 37.81091  1.000 54.67286  ? 492 ILE F CD1 1 
ATOM   3295 N N   . SER A 1 458 ? 189.14462 354.12246 38.35481  1.000 78.46281  ? 493 SER F N   1 
ATOM   3296 C CA  . SER A 1 458 ? 190.43610 354.37813 39.00183  1.000 79.68824  ? 493 SER F CA  1 
ATOM   3297 C C   . SER A 1 458 ? 191.48773 354.98569 38.06874  1.000 76.14046  ? 493 SER F C   1 
ATOM   3298 O O   . SER A 1 458 ? 192.33813 355.75474 38.52054  1.000 81.60294  ? 493 SER F O   1 
ATOM   3299 C CB  . SER A 1 458 ? 190.96733 353.08118 39.61367  1.000 75.43305  ? 493 SER F CB  1 
ATOM   3300 O OG  . SER A 1 458 ? 192.09637 352.64866 38.87485  1.000 78.31188  ? 493 SER F OG  1 
ATOM   3301 N N   . GLN A 1 459 ? 191.43819 354.69559 36.77357  1.000 75.75106  ? 494 GLN F N   1 
ATOM   3302 C CA  . GLN A 1 459 ? 192.37432 355.34018 35.85879  1.000 77.14229  ? 494 GLN F CA  1 
ATOM   3303 C C   . GLN A 1 459 ? 192.08564 356.83732 35.82706  1.000 84.45180  ? 494 GLN F C   1 
ATOM   3304 O O   . GLN A 1 459 ? 193.01222 357.65562 35.72690  1.000 78.09127  ? 494 GLN F O   1 
ATOM   3305 C CB  . GLN A 1 459 ? 192.37505 354.65881 34.48617  1.000 71.17181  ? 494 GLN F CB  1 
ATOM   3306 C CG  . GLN A 1 459 ? 192.93622 355.43626 33.32313  1.000 82.48090  ? 494 GLN F CG  1 
ATOM   3307 C CD  . GLN A 1 459 ? 192.73328 354.70889 31.98211  1.000 84.35575  ? 494 GLN F CD  1 
ATOM   3308 O OE1 . GLN A 1 459 ? 192.36363 353.51373 31.95055  1.000 74.22840  ? 494 GLN F OE1 1 
ATOM   3309 N NE2 . GLN A 1 459 ? 193.05897 355.39766 30.88094  1.000 81.36812  ? 494 GLN F NE2 1 
ATOM   3310 N N   . VAL A 1 460 ? 190.79204 357.20165 35.80577  1.000 77.56127  ? 495 VAL F N   1 
ATOM   3311 C CA  . VAL A 1 460 ? 190.40416 358.60567 35.74644  1.000 75.71448  ? 495 VAL F CA  1 
ATOM   3312 C C   . VAL A 1 460 ? 190.81606 359.28455 37.04182  1.000 77.39983  ? 495 VAL F C   1 
ATOM   3313 O O   . VAL A 1 460 ? 191.21045 360.45473 37.03862  1.000 76.73572  ? 495 VAL F O   1 
ATOM   3314 C CB  . VAL A 1 460 ? 188.89675 358.76917 35.46455  1.000 64.07249  ? 495 VAL F CB  1 
ATOM   3315 C CG1 . VAL A 1 460 ? 188.46536 360.22475 35.64597  1.000 67.06022  ? 495 VAL F CG1 1 
ATOM   3316 C CG2 . VAL A 1 460 ? 188.58573 358.33513 34.09864  1.000 61.22532  ? 495 VAL F CG2 1 
ATOM   3317 N N   . ASN A 1 461 ? 190.66471 358.60182 38.17255  1.000 71.76672  ? 496 ASN F N   1 
ATOM   3318 C CA  . ASN A 1 461 ? 191.06132 359.21821 39.43033  1.000 84.80963  ? 496 ASN F CA  1 
ATOM   3319 C C   . ASN A 1 461 ? 192.57059 359.49482 39.45320  1.000 90.19790  ? 496 ASN F C   1 
ATOM   3320 O O   . ASN A 1 461 ? 193.01399 360.49146 40.04054  1.000 93.30993  ? 496 ASN F O   1 
ATOM   3321 C CB  . ASN A 1 461 ? 190.63501 358.36191 40.62124  1.000 84.68883  ? 496 ASN F CB  1 
ATOM   3322 C CG  . ASN A 1 461 ? 189.14536 358.43027 40.88557  1.000 84.12139  ? 496 ASN F CG  1 
ATOM   3323 O OD1 . ASN A 1 461 ? 188.45227 359.32058 40.38531  1.000 81.64046  ? 496 ASN F OD1 1 
ATOM   3324 N ND2 . ASN A 1 461 ? 188.65052 357.51649 41.71153  1.000 77.96407  ? 496 ASN F ND2 1 
ATOM   3325 N N   . GLU A 1 462 ? 193.38442 358.60477 38.85751  1.000 82.07307  ? 497 GLU F N   1 
ATOM   3326 C CA  . GLU A 1 462 ? 194.82769 358.86697 38.79914  1.000 92.65909  ? 497 GLU F CA  1 
ATOM   3327 C C   . GLU A 1 462 ? 195.18070 360.05155 37.89272  1.000 90.91894  ? 497 GLU F C   1 
ATOM   3328 O O   . GLU A 1 462 ? 196.08544 360.82886 38.21868  1.000 94.88027  ? 497 GLU F O   1 
ATOM   3329 C CB  . GLU A 1 462 ? 195.58241 357.59557 38.36602  1.000 91.69165  ? 497 GLU F CB  1 
ATOM   3330 C CG  . GLU A 1 462 ? 196.32547 356.83097 39.52403  1.000 94.07194  ? 497 GLU F CG  1 
ATOM   3331 C CD  . GLU A 1 462 ? 195.41529 356.29260 40.65590  1.000 96.46065  ? 497 GLU F CD  1 
ATOM   3332 O OE1 . GLU A 1 462 ? 194.18380 356.19767 40.46415  1.000 91.28768  ? 497 GLU F OE1 1 
ATOM   3333 O OE2 . GLU A 1 462 ? 195.94571 355.93293 41.73728  1.000 88.34897  ? 497 GLU F OE2 1 
ATOM   3334 N N   . LYS A 1 463 ? 194.47077 360.23460 36.77618  1.000 89.16623  ? 498 LYS F N   1 
ATOM   3335 C CA  . LYS A 1 463 ? 194.69641 361.41843 35.94021  1.000 90.03918  ? 498 LYS F CA  1 
ATOM   3336 C C   . LYS A 1 463 ? 194.29108 362.70128 36.66582  1.000 91.78641  ? 498 LYS F C   1 
ATOM   3337 O O   . LYS A 1 463 ? 194.85718 363.76644 36.40763  1.000 94.81978  ? 498 LYS F O   1 
ATOM   3338 C CB  . LYS A 1 463 ? 193.96582 361.29479 34.60363  1.000 77.65635  ? 498 LYS F CB  1 
ATOM   3339 C CG  . LYS A 1 463 ? 194.84573 360.76586 33.48645  1.000 74.57147  ? 498 LYS F CG  1 
ATOM   3340 C CD  . LYS A 1 463 ? 194.07408 360.57551 32.18572  1.000 64.82586  ? 498 LYS F CD  1 
ATOM   3341 C CE  . LYS A 1 463 ? 194.81099 359.61603 31.21879  1.000 74.61043  ? 498 LYS F CE  1 
ATOM   3342 N NZ  . LYS A 1 463 ? 195.12103 360.13957 29.82548  1.000 74.08448  ? 498 LYS F NZ  1 
ATOM   3343 N N   . ILE A 1 464 ? 193.33168 362.61113 37.58423  1.000 90.78665  ? 499 ILE F N   1 
ATOM   3344 C CA  . ILE A 1 464 ? 192.90516 363.75627 38.38238  1.000 94.50142  ? 499 ILE F CA  1 
ATOM   3345 C C   . ILE A 1 464 ? 193.93111 364.05712 39.46660  1.000 100.16311 ? 499 ILE F C   1 
ATOM   3346 O O   . ILE A 1 464 ? 194.15315 365.22406 39.81285  1.000 102.04595 ? 499 ILE F O   1 
ATOM   3347 C CB  . ILE A 1 464 ? 191.49791 363.47480 38.94522  1.000 89.04833  ? 499 ILE F CB  1 
ATOM   3348 C CG1 . ILE A 1 464 ? 190.50321 363.30692 37.78788  1.000 82.45120  ? 499 ILE F CG1 1 
ATOM   3349 C CG2 . ILE A 1 464 ? 191.05267 364.57398 39.91062  1.000 88.46783  ? 499 ILE F CG2 1 
ATOM   3350 C CD1 . ILE A 1 464 ? 189.11893 362.88306 38.20506  1.000 70.30733  ? 499 ILE F CD1 1 
ATOM   3351 N N   . ASN A 1 465 ? 194.53838 363.02240 40.05086  1.000 102.44784 ? 500 ASN F N   1 
ATOM   3352 C CA  . ASN A 1 465 ? 195.61560 363.25932 41.00626  1.000 106.78920 ? 500 ASN F CA  1 
ATOM   3353 C C   . ASN A 1 465 ? 196.83164 363.87267 40.32507  1.000 105.80878 ? 500 ASN F C   1 
ATOM   3354 O O   . ASN A 1 465 ? 197.54895 364.66691 40.94258  1.000 105.83614 ? 500 ASN F O   1 
ATOM   3355 C CB  . ASN A 1 465 ? 196.00721 361.98134 41.74187  1.000 106.82518 ? 500 ASN F CB  1 
ATOM   3356 C CG  . ASN A 1 465 ? 195.05527 361.63568 42.84407  1.000 112.65893 ? 500 ASN F CG  1 
ATOM   3357 O OD1 . ASN A 1 465 ? 193.93668 362.13721 42.89189  1.000 115.58898 ? 500 ASN F OD1 1 
ATOM   3358 N ND2 . ASN A 1 465 ? 195.52476 360.79713 43.77745  1.000 118.07880 ? 500 ASN F ND2 1 
ATOM   3359 N N   . GLN A 1 466 ? 197.05237 363.55120 39.04512  1.000 100.69368 ? 501 GLN F N   1 
ATOM   3360 C CA  . GLN A 1 466 ? 198.17080 364.13972 38.32326  1.000 102.57268 ? 501 GLN F CA  1 
ATOM   3361 C C   . GLN A 1 466 ? 197.91580 365.58254 37.92920  1.000 112.64322 ? 501 GLN F C   1 
ATOM   3362 O O   . GLN A 1 466 ? 198.86108 366.37618 37.88454  1.000 119.48434 ? 501 GLN F O   1 
ATOM   3363 C CB  . GLN A 1 466 ? 198.40677 363.36824 37.02994  1.000 102.62326 ? 501 GLN F CB  1 
ATOM   3364 C CG  . GLN A 1 466 ? 198.84689 361.94290 37.16828  1.000 101.30926 ? 501 GLN F CG  1 
ATOM   3365 C CD  . GLN A 1 466 ? 198.95887 361.28247 35.80644  1.000 102.85602 ? 501 GLN F CD  1 
ATOM   3366 O OE1 . GLN A 1 466 ? 198.29851 360.27384 35.53260  1.000 102.18892 ? 501 GLN F OE1 1 
ATOM   3367 N NE2 . GLN A 1 466 ? 199.77134 361.86954 34.93048  1.000 102.33353 ? 501 GLN F NE2 1 
ATOM   3368 N N   . SER A 1 467 ? 196.67333 365.95265 37.63079  1.000 109.95641 ? 502 SER F N   1 
ATOM   3369 C CA  . SER A 1 467 ? 196.43787 367.35075 37.31776  1.000 109.43548 ? 502 SER F CA  1 
ATOM   3370 C C   . SER A 1 467 ? 196.35152 368.17934 38.58697  1.000 111.41897 ? 502 SER F C   1 
ATOM   3371 O O   . SER A 1 467 ? 196.61420 369.38813 38.54619  1.000 113.73715 ? 502 SER F O   1 
ATOM   3372 C CB  . SER A 1 467 ? 195.17843 367.51220 36.46484  1.000 102.97588 ? 502 SER F CB  1 
ATOM   3373 O OG  . SER A 1 467 ? 195.33934 366.86835 35.21041  1.000 95.94876  ? 502 SER F OG  1 
ATOM   3374 N N   . LEU A 1 468 ? 195.99560 367.54135 39.71099  1.000 107.52194 ? 503 LEU F N   1 
ATOM   3375 C CA  . LEU A 1 468 ? 195.96398 368.22077 40.99957  1.000 113.41431 ? 503 LEU F CA  1 
ATOM   3376 C C   . LEU A 1 468 ? 197.34622 368.38691 41.62039  1.000 121.51181 ? 503 LEU F C   1 
ATOM   3377 O O   . LEU A 1 468 ? 197.55085 369.31321 42.41711  1.000 124.75452 ? 503 LEU F O   1 
ATOM   3378 C CB  . LEU A 1 468 ? 195.08596 367.42571 41.96810  1.000 106.70219 ? 503 LEU F CB  1 
ATOM   3379 C CG  . LEU A 1 468 ? 193.56954 367.48898 41.81350  1.000 102.55596 ? 503 LEU F CG  1 
ATOM   3380 C CD1 . LEU A 1 468 ? 192.92294 366.62222 42.87813  1.000 104.24699 ? 503 LEU F CD1 1 
ATOM   3381 C CD2 . LEU A 1 468 ? 193.06165 368.91939 41.89179  1.000 94.58977  ? 503 LEU F CD2 1 
ATOM   3382 N N   . ALA A 1 469 ? 198.28777 367.48008 41.32182  1.000 122.72293 ? 504 ALA F N   1 
ATOM   3383 C CA  . ALA A 1 469 ? 199.65626 367.66512 41.80024  1.000 123.16907 ? 504 ALA F CA  1 
ATOM   3384 C C   . ALA A 1 469 ? 200.37369 368.81792 41.10246  1.000 126.58943 ? 504 ALA F C   1 
ATOM   3385 O O   . ALA A 1 469 ? 201.20897 369.48782 41.72128  1.000 127.94556 ? 504 ALA F O   1 
ATOM   3386 C CB  . ALA A 1 469 ? 200.45094 366.37215 41.62138  1.000 119.84219 ? 504 ALA F CB  1 
ATOM   3387 N N   . PHE A 1 470 ? 200.05589 369.07709 39.82671  1.000 126.46662 ? 505 PHE F N   1 
ATOM   3388 C CA  . PHE A 1 470 ? 200.66201 370.20647 39.12695  1.000 127.23825 ? 505 PHE F CA  1 
ATOM   3389 C C   . PHE A 1 470 ? 200.18445 371.54488 39.66992  1.000 128.55455 ? 505 PHE F C   1 
ATOM   3390 O O   . PHE A 1 470 ? 200.84403 372.56357 39.43310  1.000 128.46501 ? 505 PHE F O   1 
ATOM   3391 C CB  . PHE A 1 470 ? 200.41243 370.11422 37.61844  1.000 123.59629 ? 505 PHE F CB  1 
ATOM   3392 C CG  . PHE A 1 470 ? 200.94732 368.85027 36.99638  1.000 128.62771 ? 505 PHE F CG  1 
ATOM   3393 C CD1 . PHE A 1 470 ? 202.06692 368.22353 37.52879  1.000 126.83545 ? 505 PHE F CD1 1 
ATOM   3394 C CD2 . PHE A 1 470 ? 200.34620 368.29840 35.86822  1.000 129.49658 ? 505 PHE F CD2 1 
ATOM   3395 C CE1 . PHE A 1 470 ? 202.56685 367.05714 36.96235  1.000 128.50150 ? 505 PHE F CE1 1 
ATOM   3396 C CE2 . PHE A 1 470 ? 200.84245 367.13124 35.29367  1.000 127.77902 ? 505 PHE F CE2 1 
ATOM   3397 C CZ  . PHE A 1 470 ? 201.95480 366.51136 35.84194  1.000 127.05004 ? 505 PHE F CZ  1 
ATOM   3398 N N   . ILE A 1 471 ? 199.05322 371.57144 40.37922  1.000 128.87643 ? 506 ILE F N   1 
ATOM   3399 C CA  . ILE A 1 471 ? 198.58178 372.81888 40.96396  1.000 129.00725 ? 506 ILE F CA  1 
ATOM   3400 C C   . ILE A 1 471 ? 198.99081 372.85680 42.42892  1.000 132.23832 ? 506 ILE F C   1 
ATOM   3401 O O   . ILE A 1 471 ? 199.13753 373.94110 43.00208  1.000 137.87865 ? 506 ILE F O   1 
ATOM   3402 C CB  . ILE A 1 471 ? 197.06021 372.99359 40.79075  1.000 122.58149 ? 506 ILE F CB  1 
ATOM   3403 C CG1 . ILE A 1 471 ? 196.66183 372.73097 39.33350  1.000 117.84443 ? 506 ILE F CG1 1 
ATOM   3404 C CG2 . ILE A 1 471 ? 196.62145 374.37960 41.24398  1.000 122.75124 ? 506 ILE F CG2 1 
ATOM   3405 C CD1 . ILE A 1 471 ? 195.18366 372.84987 39.06911  1.000 106.74172 ? 506 ILE F CD1 1 
ATOM   3406 N N   . ARG A 1 472 ? 199.12619 371.69178 43.07299  1.000 128.12638 ? 507 ARG F N   1 
ATOM   3407 C CA  . ARG A 1 472 ? 199.55337 371.72279 44.46841  1.000 133.34466 ? 507 ARG F CA  1 
ATOM   3408 C C   . ARG A 1 472 ? 200.99223 372.23877 44.56679  1.000 139.17583 ? 507 ARG F C   1 
ATOM   3409 O O   . ARG A 1 472 ? 201.31292 373.07249 45.42518  1.000 138.89902 ? 507 ARG F O   1 
ATOM   3410 C CB  . ARG A 1 472 ? 199.40223 370.35088 45.12622  1.000 130.60822 ? 507 ARG F CB  1 
ATOM   3411 C CG  . ARG A 1 472 ? 200.15620 370.26879 46.44192  1.000 134.85071 ? 507 ARG F CG  1 
ATOM   3412 C CD  . ARG A 1 472 ? 200.04539 368.92336 47.13018  1.000 133.10805 ? 507 ARG F CD  1 
ATOM   3413 N NE  . ARG A 1 472 ? 201.03429 368.82192 48.19711  1.000 138.63128 ? 507 ARG F NE  1 
ATOM   3414 C CZ  . ARG A 1 472 ? 200.83981 369.24057 49.44118  1.000 137.19882 ? 507 ARG F CZ  1 
ATOM   3415 N NH1 . ARG A 1 472 ? 199.69801 369.79729 49.81362  1.000 136.68924 ? 507 ARG F NH1 1 
ATOM   3416 N NH2 . ARG A 1 472 ? 201.82000 369.11018 50.33040  1.000 130.16564 ? 507 ARG F NH2 1 
ATOM   3417 N N   . LYS A 1 473 ? 201.88397 371.71102 43.70761  1.000 137.84896 ? 508 LYS F N   1 
ATOM   3418 C CA  . LYS A 1 473 ? 203.28907 372.12767 43.67755  1.000 136.23095 ? 508 LYS F CA  1 
ATOM   3419 C C   . LYS A 1 473 ? 203.46282 373.55253 43.16278  1.000 137.72882 ? 508 LYS F C   1 
ATOM   3420 O O   . LYS A 1 473 ? 204.40220 374.24586 43.57246  1.000 137.18417 ? 508 LYS F O   1 
ATOM   3421 C CB  . LYS A 1 473 ? 204.13055 371.18337 42.81312  1.000 131.72699 ? 508 LYS F CB  1 
ATOM   3422 C CG  . LYS A 1 473 ? 204.64245 369.93772 43.51110  1.000 130.29667 ? 508 LYS F CG  1 
ATOM   3423 C CD  . LYS A 1 473 ? 205.33406 369.02084 42.51374  1.000 125.66511 ? 508 LYS F CD  1 
ATOM   3424 C CE  . LYS A 1 473 ? 205.06287 367.56120 42.82045  1.000 127.75443 ? 508 LYS F CE  1 
ATOM   3425 N NZ  . LYS A 1 473 ? 204.47563 366.86456 41.64498  1.000 127.14696 ? 508 LYS F NZ  1 
ATOM   3426 N N   . SER A 1 474 ? 202.56694 374.00807 42.28385  1.000 137.86334 ? 509 SER F N   1 
ATOM   3427 C CA  . SER A 1 474 ? 202.61621 375.35057 41.70149  1.000 137.80045 ? 509 SER F CA  1 
ATOM   3428 C C   . SER A 1 474 ? 201.60084 376.28425 42.34827  1.000 139.64662 ? 509 SER F C   1 
ATOM   3429 O O   . SER A 1 474 ? 200.98368 377.12417 41.68161  1.000 139.89231 ? 509 SER F O   1 
ATOM   3430 C CB  . SER A 1 474 ? 202.39604 375.28563 40.18804  1.000 132.33652 ? 509 SER F CB  1 
ATOM   3431 O OG  . SER A 1 474 ? 203.11872 374.21774 39.59380  1.000 129.35857 ? 509 SER F OG  1 
ATOM   3432 N N   . ASP A 1 475 ? 201.41322 376.12218 43.65820  1.000 139.24561 ? 510 ASP F N   1 
ATOM   3433 C CA  . ASP A 1 475 ? 200.81408 377.03460 44.62957  1.000 139.39011 ? 510 ASP F CA  1 
ATOM   3434 C C   . ASP A 1 475 ? 201.70612 377.20040 45.85122  1.000 140.49859 ? 510 ASP F C   1 
ATOM   3435 O O   . ASP A 1 475 ? 201.85036 378.31716 46.36415  1.000 136.62429 ? 510 ASP F O   1 
ATOM   3436 C CB  . ASP A 1 475 ? 199.41936 376.53734 45.07334  1.000 135.74464 ? 510 ASP F CB  1 
ATOM   3437 C CG  . ASP A 1 475 ? 198.34728 376.76360 44.02117  1.000 137.47700 ? 510 ASP F CG  1 
ATOM   3438 O OD1 . ASP A 1 475 ? 198.66960 377.26794 42.92356  1.000 138.90052 ? 510 ASP F OD1 1 
ATOM   3439 O OD2 . ASP A 1 475 ? 197.17445 376.42940 44.29596  1.000 138.44916 ? 510 ASP F OD2 1 
ATOM   3440 N N   . GLU A 1 476 ? 202.32588 376.11588 46.31007  1.000 139.10792 ? 511 GLU F N   1 
ATOM   3441 C CA  . GLU A 1 476 ? 203.22746 376.11744 47.45117  1.000 137.77327 ? 511 GLU F CA  1 
ATOM   3442 C C   . GLU A 1 476 ? 204.50958 376.89622 47.15243  1.000 134.28204 ? 511 GLU F C   1 
ATOM   3443 O O   . GLU A 1 476 ? 204.52623 378.12957 47.18384  1.000 131.96885 ? 511 GLU F O   1 
ATOM   3444 C CB  . GLU A 1 476 ? 203.55374 374.67359 47.83791  1.000 137.41988 ? 511 GLU F CB  1 
ATOM   3445 C CG  . GLU A 1 476 ? 203.80377 374.44581 49.31589  1.000 139.96007 ? 511 GLU F CG  1 
ATOM   3446 C CD  . GLU A 1 476 ? 203.81690 372.96879 49.68119  1.000 143.24076 ? 511 GLU F CD  1 
ATOM   3447 O OE1 . GLU A 1 476 ? 203.35575 372.14217 48.85993  1.000 141.83350 ? 511 GLU F OE1 1 
ATOM   3448 O OE2 . GLU A 1 476 ? 204.28952 372.63653 50.79061  1.000 142.98006 ? 511 GLU F OE2 1 
HETATM 3449 C C1  . EDO B 2 .   ? 177.46119 336.28521 38.63148  1.000 61.03137  ? 601 EDO F C1  1 
HETATM 3450 O O1  . EDO B 2 .   ? 178.46506 337.26504 38.94866  1.000 61.69592  ? 601 EDO F O1  1 
HETATM 3451 C C2  . EDO B 2 .   ? 176.05900 336.80792 38.99961  1.000 63.92289  ? 601 EDO F C2  1 
HETATM 3452 O O2  . EDO B 2 .   ? 175.03958 335.80228 38.75817  1.000 69.56302  ? 601 EDO F O2  1 
HETATM 3453 H H11 . EDO B 2 .   ? 177.66366 335.36299 39.18010  1.000 73.24984  ? 601 EDO F H11 1 
HETATM 3454 H H12 . EDO B 2 .   ? 177.49781 336.05591 37.56446  1.000 73.24984  ? 601 EDO F H12 1 
HETATM 3455 H HO1 . EDO B 2 .   ? 179.28327 337.05172 38.47950  1.000 74.04731  ? 601 EDO F HO1 1 
HETATM 3456 H H21 . EDO B 2 .   ? 175.83717 337.69820 38.40744  1.000 76.71967  ? 601 EDO F H21 1 
HETATM 3457 H H22 . EDO B 2 .   ? 176.04388 337.09347 40.05350  1.000 76.71967  ? 601 EDO F H22 1 
HETATM 3458 H HO2 . EDO B 2 .   ? 174.18565 336.12618 39.07595  1.000 83.48783  ? 601 EDO F HO2 1 
HETATM 3459 C C1  . EDO C 2 .   ? 182.65776 326.82845 27.62544  1.000 55.19957  ? 602 EDO F C1  1 
HETATM 3460 O O1  . EDO C 2 .   ? 182.30403 328.16138 27.19534  1.000 49.55608  ? 602 EDO F O1  1 
HETATM 3461 C C2  . EDO C 2 .   ? 182.49851 326.71857 29.14680  1.000 41.25030  ? 602 EDO F C2  1 
HETATM 3462 O O2  . EDO C 2 .   ? 181.09563 326.57245 29.41702  1.000 50.69697  ? 602 EDO F O2  1 
HETATM 3463 H H11 . EDO C 2 .   ? 183.69027 326.61053 27.34453  1.000 66.25169  ? 602 EDO F H11 1 
HETATM 3464 H H12 . EDO C 2 .   ? 182.01419 326.09715 27.13200  1.000 66.25169  ? 602 EDO F H12 1 
HETATM 3465 H HO1 . EDO C 2 .   ? 182.21135 328.17555 26.23290  1.000 59.47950  ? 602 EDO F HO1 1 
HETATM 3466 H H21 . EDO C 2 .   ? 182.89029 327.61233 29.63687  1.000 49.51256  ? 602 EDO F H21 1 
HETATM 3467 H H22 . EDO C 2 .   ? 183.05192 325.85740 29.52704  1.000 49.51256  ? 602 EDO F H22 1 
HETATM 3468 H HO2 . EDO C 2 .   ? 180.80198 327.29080 29.99394  1.000 60.84857  ? 602 EDO F HO2 1 
HETATM 3469 C C1  . EDO D 2 .   ? 176.75302 351.66162 39.24352  1.000 57.19222  ? 603 EDO F C1  1 
HETATM 3470 O O1  . EDO D 2 .   ? 175.43953 351.20145 38.96048  1.000 57.86156  ? 603 EDO F O1  1 
HETATM 3471 C C2  . EDO D 2 .   ? 177.01275 351.43876 40.74250  1.000 54.97284  ? 603 EDO F C2  1 
HETATM 3472 O O2  . EDO D 2 .   ? 176.07220 352.21888 41.46119  1.000 56.73724  ? 603 EDO F O2  1 
HETATM 3473 H H11 . EDO D 2 .   ? 176.84515 352.72123 38.99611  1.000 68.64287  ? 603 EDO F H11 1 
HETATM 3474 H H12 . EDO D 2 .   ? 177.48407 351.11271 38.64626  1.000 68.64287  ? 603 EDO F H12 1 
HETATM 3475 H HO1 . EDO D 2 .   ? 175.12668 351.60483 38.13920  1.000 69.44607  ? 603 EDO F HO1 1 
HETATM 3476 H H21 . EDO D 2 .   ? 178.03060 351.73895 41.00007  1.000 65.97961  ? 603 EDO F H21 1 
HETATM 3477 H H22 . EDO D 2 .   ? 176.90063 350.38208 40.99413  1.000 65.97961  ? 603 EDO F H22 1 
HETATM 3478 H HO2 . EDO D 2 .   ? 175.65796 351.67509 42.14514  1.000 68.09689  ? 603 EDO F HO2 1 
HETATM 3479 C C1  . NAG E 3 .   ? 194.89872 360.29268 44.98270  1.000 121.81863 ? 604 NAG F C1  1 
HETATM 3480 C C2  . NAG E 3 .   ? 193.46133 359.76395 44.83774  1.000 127.09858 ? 604 NAG F C2  1 
HETATM 3481 C C3  . NAG E 3 .   ? 192.98343 359.18383 46.17912  1.000 129.14504 ? 604 NAG F C3  1 
HETATM 3482 C C4  . NAG E 3 .   ? 193.97165 358.15135 46.71569  1.000 126.94504 ? 604 NAG F C4  1 
HETATM 3483 C C5  . NAG E 3 .   ? 195.37271 358.75083 46.79258  1.000 128.27535 ? 604 NAG F C5  1 
HETATM 3484 C C6  . NAG E 3 .   ? 196.43208 357.76861 47.24426  1.000 126.97721 ? 604 NAG F C6  1 
HETATM 3485 C C7  . NAG E 3 .   ? 191.49297 360.71310 43.62110  1.000 114.14891 ? 604 NAG F C7  1 
HETATM 3486 C C8  . NAG E 3 .   ? 190.74571 361.98152 43.30623  1.000 99.10658  ? 604 NAG F C8  1 
HETATM 3487 N N2  . NAG E 3 .   ? 192.57937 360.84749 44.40530  1.000 126.80948 ? 604 NAG F N2  1 
HETATM 3488 O O3  . NAG E 3 .   ? 191.71018 358.56989 46.01255  1.000 132.04737 ? 604 NAG F O3  1 
HETATM 3489 O O4  . NAG E 3 .   ? 193.58750 357.68499 48.00583  1.000 121.90330 ? 604 NAG F O4  1 
HETATM 3490 O O5  . NAG E 3 .   ? 195.76155 359.24419 45.50109  1.000 125.23010 ? 604 NAG F O5  1 
HETATM 3491 O O6  . NAG E 3 .   ? 196.94991 358.10499 48.52582  1.000 118.40943 ? 604 NAG F O6  1 
HETATM 3492 O O7  . NAG E 3 .   ? 191.12632 359.62510 43.18911  1.000 111.55652 ? 604 NAG F O7  1 
HETATM 3493 O O   . HOH F 4 .   ? 183.62651 347.58350 41.71560  1.000 56.68772  ? 701 HOH F O   1 
HETATM 3494 O O   . HOH F 4 .   ? 175.51917 353.75613 43.06976  1.000 59.81607  ? 702 HOH F O   1 
HETATM 3495 O O   . HOH F 4 .   ? 156.08183 359.88574 22.85914  1.000 45.13725  ? 703 HOH F O   1 
HETATM 3496 O O   . HOH F 4 .   ? 162.06509 339.04467 26.10855  1.000 56.96720  ? 704 HOH F O   1 
HETATM 3497 O O   . HOH F 4 .   ? 165.16693 369.79040 28.15162  1.000 44.34195  ? 705 HOH F O   1 
HETATM 3498 O O   . HOH F 4 .   ? 184.12673 323.46839 14.64461  1.000 52.84681  ? 706 HOH F O   1 
HETATM 3499 O O   . HOH F 4 .   ? 167.28378 368.20241 21.05397  1.000 51.89383  ? 707 HOH F O   1 
HETATM 3500 O O   . HOH F 4 .   ? 171.03844 357.00339 25.44367  1.000 47.84637  ? 708 HOH F O   1 
HETATM 3501 O O   . HOH F 4 .   ? 159.98877 365.10992 22.31016  1.000 48.03067  ? 709 HOH F O   1 
HETATM 3502 O O   . HOH F 4 .   ? 155.97709 360.94013 24.95109  1.000 43.96217  ? 710 HOH F O   1 
HETATM 3503 O O   . HOH F 4 .   ? 173.67210 332.68842 11.39254  1.000 47.16488  ? 711 HOH F O   1 
HETATM 3504 O O   . HOH F 4 .   ? 186.27299 364.69221 24.27784  1.000 62.54789  ? 712 HOH F O   1 
HETATM 3505 O O   . HOH F 4 .   ? 185.47150 350.48041 40.31399  1.000 52.68954  ? 713 HOH F O   1 
HETATM 3506 O O   . HOH F 4 .   ? 184.32392 373.91329 26.50982  1.000 69.00157  ? 714 HOH F O   1 
HETATM 3507 O O   . HOH F 4 .   ? 170.65636 348.56732 25.53442  1.000 43.89763  ? 715 HOH F O   1 
HETATM 3508 O O   . HOH F 4 .   ? 169.92999 336.89530 35.42132  1.000 47.82156  ? 716 HOH F O   1 
HETATM 3509 O O   . HOH F 4 .   ? 155.64145 353.66375 34.26237  1.000 48.43714  ? 717 HOH F O   1 
HETATM 3510 O O   . HOH F 4 .   ? 174.04045 369.22460 29.85735  1.000 55.52177  ? 718 HOH F O   1 
HETATM 3511 O O   . HOH F 4 .   ? 171.46904 370.19860 29.73536  1.000 46.82024  ? 719 HOH F O   1 
HETATM 3512 O O   . HOH F 4 .   ? 180.18006 348.56181 32.57045  1.000 43.46903  ? 720 HOH F O   1 
HETATM 3513 O O   . HOH F 4 .   ? 168.33507 353.98601 46.48198  1.000 64.08450  ? 721 HOH F O   1 
HETATM 3514 O O   . HOH F 4 .   ? 171.05063 360.20036 36.73007  1.000 46.84997  ? 722 HOH F O   1 
HETATM 3515 O O   . HOH F 4 .   ? 183.28949 348.12663 33.40612  1.000 52.19178  ? 723 HOH F O   1 
HETATM 3516 O O   . HOH F 4 .   ? 168.20610 334.42584 35.31168  1.000 50.03866  ? 724 HOH F O   1 
HETATM 3517 O O   . HOH F 4 .   ? 186.35654 344.87869 28.94242  1.000 61.69886  ? 725 HOH F O   1 
HETATM 3518 O O   . HOH F 4 .   ? 173.09150 364.67988 35.73082  1.000 49.13901  ? 726 HOH F O   1 
HETATM 3519 O O   . HOH F 4 .   ? 180.13919 332.58398 36.98815  1.000 54.37458  ? 727 HOH F O   1 
HETATM 3520 O O   . HOH F 4 .   ? 188.39997 337.11033 39.62719  1.000 44.57019  ? 728 HOH F O   1 
HETATM 3521 O O   . HOH F 4 .   ? 169.01816 376.65366 27.16851  1.000 59.07258  ? 729 HOH F O   1 
HETATM 3522 O O   . HOH F 4 .   ? 162.53649 330.78466 19.19957  1.000 64.69160  ? 730 HOH F O   1 
HETATM 3523 O O   . HOH F 4 .   ? 174.85544 341.77077 23.33967  1.000 46.90052  ? 731 HOH F O   1 
HETATM 3524 O O   . HOH F 4 .   ? 176.26045 355.24108 31.80911  1.000 35.70459  ? 732 HOH F O   1 
HETATM 3525 O O   . HOH F 4 .   ? 176.20917 357.72889 43.83793  1.000 56.79617  ? 733 HOH F O   1 
HETATM 3526 O O   . HOH F 4 .   ? 157.68091 347.70585 37.29356  1.000 59.16493  ? 734 HOH F O   1 
HETATM 3527 O O   . HOH F 4 .   ? 179.47953 346.76224 23.91160  1.000 53.21618  ? 735 HOH F O   1 
HETATM 3528 O O   . HOH F 4 .   ? 163.76317 363.83795 34.64947  1.000 55.22629  ? 736 HOH F O   1 
HETATM 3529 O O   . HOH F 4 .   ? 158.21872 347.44124 34.67458  1.000 56.02506  ? 737 HOH F O   1 
HETATM 3530 O O   . HOH F 4 .   ? 173.91682 366.48413 37.65697  1.000 57.40572  ? 738 HOH F O   1 
HETATM 3531 O O   . HOH F 4 .   ? 154.67635 350.09761 23.29937  1.000 49.60284  ? 739 HOH F O   1 
HETATM 3532 O O   . HOH F 4 .   ? 179.24459 345.40331 34.74629  1.000 44.88566  ? 740 HOH F O   1 
HETATM 3533 O O   . HOH F 4 .   ? 166.07281 362.99654 32.19256  1.000 49.00245  ? 741 HOH F O   1 
HETATM 3534 O O   . HOH F 4 .   ? 169.44797 329.64170 36.56976  1.000 57.14875  ? 742 HOH F O   1 
HETATM 3535 O O   . HOH F 4 .   ? 180.27625 360.15289 27.86728  1.000 43.29981  ? 743 HOH F O   1 
HETATM 3536 O O   . HOH F 4 .   ? 171.80916 354.67044 41.69482  1.000 49.59356  ? 744 HOH F O   1 
HETATM 3537 O O   . HOH F 4 .   ? 162.23254 367.63949 28.47522  1.000 37.08617  ? 745 HOH F O   1 
HETATM 3538 O O   . HOH F 4 .   ? 160.96722 351.22802 41.61970  1.000 58.48105  ? 746 HOH F O   1 
HETATM 3539 O O   . HOH F 4 .   ? 183.61922 345.92649 31.98899  1.000 47.75161  ? 747 HOH F O   1 
HETATM 3540 O O   . HOH F 4 .   ? 174.35481 369.03771 37.07723  1.000 62.41138  ? 748 HOH F O   1 
HETATM 3541 O O   . HOH F 4 .   ? 173.96367 340.16009 21.47650  1.000 51.39294  ? 749 HOH F O   1 
HETATM 3542 O O   . HOH F 4 .   ? 176.07262 328.67470 35.19780  1.000 48.32085  ? 750 HOH F O   1 
HETATM 3543 O O   . HOH F 4 .   ? 178.56795 351.11744 26.84772  1.000 49.50775  ? 751 HOH F O   1 
HETATM 3544 O O   . HOH F 4 .   ? 150.92138 348.98857 30.95124  1.000 58.86368  ? 752 HOH F O   1 
HETATM 3545 O O   . HOH F 4 .   ? 149.97963 355.99119 32.35583  1.000 60.06728  ? 753 HOH F O   1 
HETATM 3546 O O   . HOH F 4 .   ? 181.87913 349.71637 25.37085  1.000 54.56222  ? 754 HOH F O   1 
HETATM 3547 O O   . HOH F 4 .   ? 172.68242 347.04720 25.74691  1.000 41.61949  ? 755 HOH F O   1 
HETATM 3548 O O   . HOH F 4 .   ? 172.53085 350.48443 26.27760  1.000 36.20911  ? 756 HOH F O   1 
HETATM 3549 O O   . HOH F 4 .   ? 166.32799 344.32454 26.20999  1.000 47.41847  ? 757 HOH F O   1 
HETATM 3550 O O   . HOH F 4 .   ? 182.33992 346.62459 24.42517  1.000 54.43092  ? 758 HOH F O   1 
HETATM 3551 O O   . HOH F 4 .   ? 161.05617 322.57723 5.61315   1.000 59.17707  ? 759 HOH F O   1 
HETATM 3552 O O   . HOH F 4 .   ? 185.76760 334.76172 38.07427  1.000 47.06756  ? 760 HOH F O   1 
HETATM 3553 O O   . HOH F 4 .   ? 171.30937 362.78401 36.05852  1.000 41.45132  ? 761 HOH F O   1 
HETATM 3554 O O   . HOH F 4 .   ? 183.23623 325.17826 20.06618  1.000 46.55379  ? 762 HOH F O   1 
HETATM 3555 O O   . HOH F 4 .   ? 166.53742 346.28459 24.91595  1.000 49.17218  ? 763 HOH F O   1 
HETATM 3556 O O   . HOH F 4 .   ? 172.37297 321.08668 22.45511  1.000 53.77408  ? 764 HOH F O   1 
HETATM 3557 O O   . HOH F 4 .   ? 166.87607 352.04901 22.11557  1.000 43.08749  ? 765 HOH F O   1 
HETATM 3558 O O   . HOH F 4 .   ? 156.15879 345.04818 22.99675  1.000 53.66681  ? 766 HOH F O   1 
HETATM 3559 O O   . HOH F 4 .   ? 151.518   360.641   35.521    1.000 60.94274  ? 767 HOH F O   1 
HETATM 3560 O O   . HOH F 4 .   ? 165.99129 353.50705 45.80222  1.000 63.32709  ? 768 HOH F O   1 
HETATM 3561 O O   . HOH F 4 .   ? 176.77043 333.12276 5.51160   1.000 58.70367  ? 769 HOH F O   1 
HETATM 3562 O O   . HOH F 4 .   ? 163.24507 368.93316 21.24562  1.000 46.62990  ? 770 HOH F O   1 
HETATM 3563 O O   . HOH F 4 .   ? 188.20000 341.66364 39.11287  1.000 50.30336  ? 771 HOH F O   1 
HETATM 3564 O O   . HOH F 4 .   ? 175.46711 331.75644 4.02709   1.000 50.16859  ? 772 HOH F O   1 
HETATM 3565 O O   . HOH F 4 .   ? 177.88230 357.56006 25.13599  1.000 50.92160  ? 773 HOH F O   1 
HETATM 3566 O O   . HOH F 4 .   ? 188.40078 336.76468 26.44696  1.000 46.98620  ? 774 HOH F O   1 
HETATM 3567 O O   . HOH F 4 .   ? 163.39678 338.10049 40.83577  1.000 65.01698  ? 775 HOH F O   1 
HETATM 3568 O O   . HOH F 4 .   ? 175.60251 356.46161 24.19393  1.000 51.58507  ? 776 HOH F O   1 
HETATM 3569 O O   . HOH F 4 .   ? 173.72931 346.51016 23.42886  1.000 50.77189  ? 777 HOH F O   1 
HETATM 3570 O O   . HOH F 4 .   ? 184.33587 345.02307 23.52952  1.000 52.12480  ? 778 HOH F O   1 
HETATM 3571 O O   . HOH F 4 .   ? 188.19204 335.33349 37.76556  1.000 55.84288  ? 779 HOH F O   1 
# 
