data_8W3J
# 
_entry.id   8W3J 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W3J         pdb_00008w3j 10.2210/pdb8w3j/pdb 
WWPDB D_1000280346 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W3J 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jiang@scripps.edu 
_pdbx_contact_author.name_first         JIANG 
_pdbx_contact_author.name_last          ZHU 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0259-7157 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lee, Y.Z.'       1 ? 
'Stanfield, R.L.' 2 ? 
'Wilson, I.A.'    3 ? 
'Zhu, J.'         4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9939 
_citation.page_last                 9939 
_citation.title                     
'Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54287-x 
_citation.pdbx_database_id_PubMed   39550381 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lee, Y.Z.'       1  0000-0002-5651-863X 
primary 'Han, J.'         2  ?                   
primary 'Zhang, Y.N.'     3  0000-0001-9053-5890 
primary 'Ward, G.'        4  ?                   
primary 'Braz Gomes, K.'  5  ?                   
primary 'Auclair, S.'     6  ?                   
primary 'Stanfield, R.L.' 7  ?                   
primary 'He, L.'          8  ?                   
primary 'Wilson, I.A.'    9  0000-0002-6469-2419 
primary 'Zhu, J.'         10 0000-0003-0259-7157 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Prefusion-stabilized RSV F protein UFCR2-iSS' 55653.645 1  ? ? ? ? 
2 non-polymer syn 1,2-ETHANEDIOL                                 62.068    1  ? ? ? ? 
3 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose       221.208   1  ? ? ? ? 
4 water       nat water                                          18.015    12 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_strand_id                 F 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1,2-ETHANEDIOL                           EDO 
3 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
4 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   ILE n 
1 4   LEU n 
1 5   PRO n 
1 6   SER n 
1 7   PRO n 
1 8   GLY n 
1 9   MET n 
1 10  PRO n 
1 11  ALA n 
1 12  LEU n 
1 13  LEU n 
1 14  SER n 
1 15  LEU n 
1 16  VAL n 
1 17  SER n 
1 18  LEU n 
1 19  LEU n 
1 20  SER n 
1 21  VAL n 
1 22  LEU n 
1 23  LEU n 
1 24  MET n 
1 25  GLY n 
1 26  CYS n 
1 27  VAL n 
1 28  ALA n 
1 29  GLU n 
1 30  GLN n 
1 31  ASN n 
1 32  ILE n 
1 33  THR n 
1 34  GLU n 
1 35  GLU n 
1 36  PHE n 
1 37  TYR n 
1 38  GLN n 
1 39  SER n 
1 40  THR n 
1 41  CYS n 
1 42  SER n 
1 43  ALA n 
1 44  VAL n 
1 45  SER n 
1 46  LYS n 
1 47  GLY n 
1 48  TYR n 
1 49  LEU n 
1 50  GLY n 
1 51  ALA n 
1 52  LEU n 
1 53  ARG n 
1 54  THR n 
1 55  GLY n 
1 56  TRP n 
1 57  TYR n 
1 58  THR n 
1 59  SER n 
1 60  VAL n 
1 61  ILE n 
1 62  THR n 
1 63  ILE n 
1 64  GLU n 
1 65  LEU n 
1 66  SER n 
1 67  ASN n 
1 68  ILE n 
1 69  LYS n 
1 70  GLU n 
1 71  ASN n 
1 72  LYS n 
1 73  CYS n 
1 74  ASN n 
1 75  GLY n 
1 76  THR n 
1 77  ASP n 
1 78  ALA n 
1 79  LYS n 
1 80  VAL n 
1 81  LYS n 
1 82  LEU n 
1 83  ILE n 
1 84  LYS n 
1 85  GLN n 
1 86  GLU n 
1 87  LEU n 
1 88  ASP n 
1 89  LYS n 
1 90  TYR n 
1 91  LYS n 
1 92  ASN n 
1 93  ALA n 
1 94  VAL n 
1 95  THR n 
1 96  ASP n 
1 97  LEU n 
1 98  GLN n 
1 99  LEU n 
1 100 LEU n 
1 101 MET n 
1 102 GLN n 
1 103 SER n 
1 104 THR n 
1 105 PRO n 
1 106 ALA n 
1 107 THR n 
1 108 GLY n 
1 109 SER n 
1 110 GLY n 
1 111 SER n 
1 112 ALA n 
1 113 ILE n 
1 114 CYS n 
1 115 SER n 
1 116 GLY n 
1 117 VAL n 
1 118 ALA n 
1 119 VAL n 
1 120 CYS n 
1 121 LYS n 
1 122 VAL n 
1 123 LEU n 
1 124 HIS n 
1 125 LEU n 
1 126 GLU n 
1 127 GLY n 
1 128 GLU n 
1 129 VAL n 
1 130 ASN n 
1 131 LYS n 
1 132 ILE n 
1 133 LYS n 
1 134 SER n 
1 135 ALA n 
1 136 LEU n 
1 137 LEU n 
1 138 SER n 
1 139 THR n 
1 140 ASN n 
1 141 LYS n 
1 142 ALA n 
1 143 VAL n 
1 144 VAL n 
1 145 SER n 
1 146 LEU n 
1 147 SER n 
1 148 ASN n 
1 149 GLY n 
1 150 VAL n 
1 151 SER n 
1 152 VAL n 
1 153 LEU n 
1 154 THR n 
1 155 SER n 
1 156 LYS n 
1 157 VAL n 
1 158 LEU n 
1 159 ASP n 
1 160 LEU n 
1 161 LYS n 
1 162 ASN n 
1 163 TYR n 
1 164 ILE n 
1 165 ASP n 
1 166 LYS n 
1 167 GLN n 
1 168 LEU n 
1 169 LEU n 
1 170 PRO n 
1 171 ILE n 
1 172 VAL n 
1 173 ASN n 
1 174 LYS n 
1 175 GLN n 
1 176 SER n 
1 177 CYS n 
1 178 SER n 
1 179 ILE n 
1 180 PRO n 
1 181 ASN n 
1 182 ILE n 
1 183 GLU n 
1 184 THR n 
1 185 VAL n 
1 186 ILE n 
1 187 GLU n 
1 188 PHE n 
1 189 GLN n 
1 190 GLN n 
1 191 LYS n 
1 192 ASN n 
1 193 ASN n 
1 194 ARG n 
1 195 LEU n 
1 196 LEU n 
1 197 GLU n 
1 198 ILE n 
1 199 THR n 
1 200 ARG n 
1 201 GLU n 
1 202 PHE n 
1 203 SER n 
1 204 VAL n 
1 205 ASN n 
1 206 ALA n 
1 207 GLY n 
1 208 VAL n 
1 209 THR n 
1 210 THR n 
1 211 PRO n 
1 212 VAL n 
1 213 SER n 
1 214 THR n 
1 215 TYR n 
1 216 MET n 
1 217 LEU n 
1 218 THR n 
1 219 ASN n 
1 220 SER n 
1 221 GLU n 
1 222 LEU n 
1 223 LEU n 
1 224 SER n 
1 225 LEU n 
1 226 ILE n 
1 227 ASN n 
1 228 ASP n 
1 229 MET n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 ASN n 
1 234 ASP n 
1 235 GLN n 
1 236 LYS n 
1 237 LYS n 
1 238 LEU n 
1 239 MET n 
1 240 SER n 
1 241 ASN n 
1 242 ASN n 
1 243 VAL n 
1 244 GLN n 
1 245 ILE n 
1 246 VAL n 
1 247 ARG n 
1 248 GLN n 
1 249 GLN n 
1 250 SER n 
1 251 TYR n 
1 252 SER n 
1 253 ILE n 
1 254 MET n 
1 255 CYS n 
1 256 ILE n 
1 257 ILE n 
1 258 LYS n 
1 259 GLU n 
1 260 GLU n 
1 261 VAL n 
1 262 LEU n 
1 263 ALA n 
1 264 TYR n 
1 265 VAL n 
1 266 VAL n 
1 267 GLN n 
1 268 LEU n 
1 269 PRO n 
1 270 LEU n 
1 271 TYR n 
1 272 GLY n 
1 273 VAL n 
1 274 ILE n 
1 275 ASP n 
1 276 THR n 
1 277 PRO n 
1 278 CYS n 
1 279 TRP n 
1 280 LYS n 
1 281 LEU n 
1 282 HIS n 
1 283 THR n 
1 284 SER n 
1 285 PRO n 
1 286 LEU n 
1 287 CYS n 
1 288 THR n 
1 289 THR n 
1 290 ASN n 
1 291 THR n 
1 292 LYS n 
1 293 GLU n 
1 294 GLY n 
1 295 SER n 
1 296 ASN n 
1 297 ILE n 
1 298 CYS n 
1 299 LEU n 
1 300 THR n 
1 301 ARG n 
1 302 THR n 
1 303 ASP n 
1 304 ARG n 
1 305 GLY n 
1 306 TRP n 
1 307 TYR n 
1 308 CYS n 
1 309 ASP n 
1 310 ASN n 
1 311 ALA n 
1 312 GLY n 
1 313 SER n 
1 314 VAL n 
1 315 SER n 
1 316 PHE n 
1 317 PHE n 
1 318 PRO n 
1 319 GLN n 
1 320 ALA n 
1 321 GLU n 
1 322 THR n 
1 323 CYS n 
1 324 LYS n 
1 325 VAL n 
1 326 GLN n 
1 327 SER n 
1 328 ASN n 
1 329 ARG n 
1 330 VAL n 
1 331 PHE n 
1 332 CYS n 
1 333 ASP n 
1 334 THR n 
1 335 MET n 
1 336 ASN n 
1 337 SER n 
1 338 LEU n 
1 339 THR n 
1 340 LEU n 
1 341 PRO n 
1 342 SER n 
1 343 GLU n 
1 344 VAL n 
1 345 ASN n 
1 346 LEU n 
1 347 CYS n 
1 348 ASN n 
1 349 VAL n 
1 350 ASP n 
1 351 ILE n 
1 352 PHE n 
1 353 ASN n 
1 354 PRO n 
1 355 LYS n 
1 356 TYR n 
1 357 ASP n 
1 358 CYS n 
1 359 LYS n 
1 360 ILE n 
1 361 MET n 
1 362 THR n 
1 363 SER n 
1 364 LYS n 
1 365 THR n 
1 366 ASP n 
1 367 VAL n 
1 368 SER n 
1 369 SER n 
1 370 SER n 
1 371 VAL n 
1 372 ILE n 
1 373 THR n 
1 374 SER n 
1 375 LEU n 
1 376 GLY n 
1 377 ALA n 
1 378 ILE n 
1 379 VAL n 
1 380 SER n 
1 381 CYS n 
1 382 TYR n 
1 383 GLY n 
1 384 LYS n 
1 385 THR n 
1 386 LYS n 
1 387 CYS n 
1 388 THR n 
1 389 ALA n 
1 390 SER n 
1 391 ASN n 
1 392 LYS n 
1 393 ASN n 
1 394 ARG n 
1 395 GLY n 
1 396 ILE n 
1 397 ILE n 
1 398 LYS n 
1 399 THR n 
1 400 PHE n 
1 401 SER n 
1 402 ASN n 
1 403 GLY n 
1 404 CYS n 
1 405 ASP n 
1 406 TYR n 
1 407 VAL n 
1 408 SER n 
1 409 ASN n 
1 410 LYS n 
1 411 GLY n 
1 412 VAL n 
1 413 ASP n 
1 414 THR n 
1 415 VAL n 
1 416 SER n 
1 417 VAL n 
1 418 GLY n 
1 419 ASN n 
1 420 THR n 
1 421 LEU n 
1 422 TYR n 
1 423 CYS n 
1 424 VAL n 
1 425 ASN n 
1 426 LYS n 
1 427 GLN n 
1 428 GLU n 
1 429 GLY n 
1 430 GLN n 
1 431 SER n 
1 432 LEU n 
1 433 TYR n 
1 434 VAL n 
1 435 LYS n 
1 436 GLY n 
1 437 GLU n 
1 438 PRO n 
1 439 ILE n 
1 440 ILE n 
1 441 ASN n 
1 442 PHE n 
1 443 TYR n 
1 444 ASP n 
1 445 PRO n 
1 446 LEU n 
1 447 VAL n 
1 448 PHE n 
1 449 PRO n 
1 450 SER n 
1 451 ASP n 
1 452 GLU n 
1 453 PHE n 
1 454 ASP n 
1 455 ALA n 
1 456 SER n 
1 457 ILE n 
1 458 SER n 
1 459 GLN n 
1 460 VAL n 
1 461 ASN n 
1 462 GLU n 
1 463 LYS n 
1 464 ILE n 
1 465 ASN n 
1 466 GLN n 
1 467 SER n 
1 468 LEU n 
1 469 ALA n 
1 470 PHE n 
1 471 ILE n 
1 472 ARG n 
1 473 LYS n 
1 474 SER n 
1 475 ASP n 
1 476 GLU n 
1 477 LEU n 
1 478 LEU n 
1 479 ALA n 
1 480 SER n 
1 481 GLY n 
1 482 TYR n 
1 483 ILE n 
1 484 PRO n 
1 485 GLU n 
1 486 ALA n 
1 487 PRO n 
1 488 ARG n 
1 489 ASP n 
1 490 GLY n 
1 491 GLN n 
1 492 ALA n 
1 493 TYR n 
1 494 VAL n 
1 495 ARG n 
1 496 LYS n 
1 497 ASP n 
1 498 GLY n 
1 499 GLU n 
1 500 TRP n 
1 501 VAL n 
1 502 LEU n 
1 503 LEU n 
1 504 SER n 
1 505 THR n 
1 506 PHE n 
1 507 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   507 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Human respiratory syncytial virus A2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11259 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
EDO non-polymer                  . 1,2-ETHANEDIOL                           'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -3  ?   ?   ?   F . n 
A 1 2   GLY 2   -2  ?   ?   ?   F . n 
A 1 3   ILE 3   -1  ?   ?   ?   F . n 
A 1 4   LEU 4   0   ?   ?   ?   F . n 
A 1 5   PRO 5   1   ?   ?   ?   F . n 
A 1 6   SER 6   2   ?   ?   ?   F . n 
A 1 7   PRO 7   3   ?   ?   ?   F . n 
A 1 8   GLY 8   4   ?   ?   ?   F . n 
A 1 9   MET 9   5   ?   ?   ?   F . n 
A 1 10  PRO 10  6   ?   ?   ?   F . n 
A 1 11  ALA 11  7   ?   ?   ?   F . n 
A 1 12  LEU 12  8   ?   ?   ?   F . n 
A 1 13  LEU 13  9   ?   ?   ?   F . n 
A 1 14  SER 14  10  ?   ?   ?   F . n 
A 1 15  LEU 15  11  ?   ?   ?   F . n 
A 1 16  VAL 16  12  ?   ?   ?   F . n 
A 1 17  SER 17  13  ?   ?   ?   F . n 
A 1 18  LEU 18  14  ?   ?   ?   F . n 
A 1 19  LEU 19  15  ?   ?   ?   F . n 
A 1 20  SER 20  16  ?   ?   ?   F . n 
A 1 21  VAL 21  17  ?   ?   ?   F . n 
A 1 22  LEU 22  18  ?   ?   ?   F . n 
A 1 23  LEU 23  19  ?   ?   ?   F . n 
A 1 24  MET 24  20  ?   ?   ?   F . n 
A 1 25  GLY 25  21  ?   ?   ?   F . n 
A 1 26  CYS 26  22  ?   ?   ?   F . n 
A 1 27  VAL 27  23  ?   ?   ?   F . n 
A 1 28  ALA 28  24  ?   ?   ?   F . n 
A 1 29  GLU 29  25  ?   ?   ?   F . n 
A 1 30  GLN 30  26  26  GLN GLN F . n 
A 1 31  ASN 31  27  27  ASN ASN F . n 
A 1 32  ILE 32  28  28  ILE ILE F . n 
A 1 33  THR 33  29  29  THR THR F . n 
A 1 34  GLU 34  30  30  GLU GLU F . n 
A 1 35  GLU 35  31  31  GLU GLU F . n 
A 1 36  PHE 36  32  32  PHE PHE F . n 
A 1 37  TYR 37  33  33  TYR TYR F . n 
A 1 38  GLN 38  34  34  GLN GLN F . n 
A 1 39  SER 39  35  35  SER SER F . n 
A 1 40  THR 40  36  36  THR THR F . n 
A 1 41  CYS 41  37  37  CYS CYS F . n 
A 1 42  SER 42  38  38  SER SER F . n 
A 1 43  ALA 43  39  39  ALA ALA F . n 
A 1 44  VAL 44  40  40  VAL VAL F . n 
A 1 45  SER 45  41  41  SER SER F . n 
A 1 46  LYS 46  42  42  LYS LYS F . n 
A 1 47  GLY 47  43  43  GLY GLY F . n 
A 1 48  TYR 48  44  44  TYR TYR F . n 
A 1 49  LEU 49  45  45  LEU LEU F . n 
A 1 50  GLY 50  46  46  GLY GLY F . n 
A 1 51  ALA 51  47  47  ALA ALA F . n 
A 1 52  LEU 52  48  48  LEU LEU F . n 
A 1 53  ARG 53  49  49  ARG ARG F . n 
A 1 54  THR 54  50  50  THR THR F . n 
A 1 55  GLY 55  51  51  GLY GLY F . n 
A 1 56  TRP 56  52  52  TRP TRP F . n 
A 1 57  TYR 57  53  53  TYR TYR F . n 
A 1 58  THR 58  54  54  THR THR F . n 
A 1 59  SER 59  55  55  SER SER F . n 
A 1 60  VAL 60  56  56  VAL VAL F . n 
A 1 61  ILE 61  57  57  ILE ILE F . n 
A 1 62  THR 62  58  58  THR THR F . n 
A 1 63  ILE 63  59  59  ILE ILE F . n 
A 1 64  GLU 64  60  60  GLU GLU F . n 
A 1 65  LEU 65  61  61  LEU LEU F . n 
A 1 66  SER 66  62  62  SER SER F . n 
A 1 67  ASN 67  63  63  ASN ASN F . n 
A 1 68  ILE 68  64  64  ILE ILE F . n 
A 1 69  LYS 69  65  65  LYS LYS F . n 
A 1 70  GLU 70  66  66  GLU GLU F . n 
A 1 71  ASN 71  67  67  ASN ASN F . n 
A 1 72  LYS 72  68  68  LYS LYS F . n 
A 1 73  CYS 73  69  69  CYS CYS F . n 
A 1 74  ASN 74  70  70  ASN ASN F . n 
A 1 75  GLY 75  71  71  GLY GLY F . n 
A 1 76  THR 76  72  72  THR THR F . n 
A 1 77  ASP 77  73  73  ASP ASP F . n 
A 1 78  ALA 78  74  74  ALA ALA F . n 
A 1 79  LYS 79  75  75  LYS LYS F . n 
A 1 80  VAL 80  76  76  VAL VAL F . n 
A 1 81  LYS 81  77  77  LYS LYS F . n 
A 1 82  LEU 82  78  78  LEU LEU F . n 
A 1 83  ILE 83  79  79  ILE ILE F . n 
A 1 84  LYS 84  80  80  LYS LYS F . n 
A 1 85  GLN 85  81  81  GLN GLN F . n 
A 1 86  GLU 86  82  82  GLU GLU F . n 
A 1 87  LEU 87  83  83  LEU LEU F . n 
A 1 88  ASP 88  84  84  ASP ASP F . n 
A 1 89  LYS 89  85  85  LYS LYS F . n 
A 1 90  TYR 90  86  86  TYR TYR F . n 
A 1 91  LYS 91  87  87  LYS LYS F . n 
A 1 92  ASN 92  88  88  ASN ASN F . n 
A 1 93  ALA 93  89  89  ALA ALA F . n 
A 1 94  VAL 94  90  90  VAL VAL F . n 
A 1 95  THR 95  91  91  THR THR F . n 
A 1 96  ASP 96  92  92  ASP ASP F . n 
A 1 97  LEU 97  93  93  LEU LEU F . n 
A 1 98  GLN 98  94  94  GLN GLN F . n 
A 1 99  LEU 99  95  95  LEU LEU F . n 
A 1 100 LEU 100 96  96  LEU LEU F . n 
A 1 101 MET 101 97  97  MET MET F . n 
A 1 102 GLN 102 98  98  GLN GLN F . n 
A 1 103 SER 103 99  99  SER SER F . n 
A 1 104 THR 104 100 100 THR THR F . n 
A 1 105 PRO 105 101 101 PRO PRO F . n 
A 1 106 ALA 106 102 102 ALA ALA F . n 
A 1 107 THR 107 103 103 THR THR F . n 
A 1 108 GLY 108 143 143 GLY GLY F . n 
A 1 109 SER 109 144 144 SER SER F . n 
A 1 110 GLY 110 145 145 GLY GLY F . n 
A 1 111 SER 111 146 146 SER SER F . n 
A 1 112 ALA 112 147 147 ALA ALA F . n 
A 1 113 ILE 113 148 148 ILE ILE F . n 
A 1 114 CYS 114 149 149 CYS CYS F . n 
A 1 115 SER 115 150 150 SER SER F . n 
A 1 116 GLY 116 151 151 GLY GLY F . n 
A 1 117 VAL 117 152 152 VAL VAL F . n 
A 1 118 ALA 118 153 153 ALA ALA F . n 
A 1 119 VAL 119 154 154 VAL VAL F . n 
A 1 120 CYS 120 155 155 CYS CYS F . n 
A 1 121 LYS 121 156 156 LYS LYS F . n 
A 1 122 VAL 122 157 157 VAL VAL F . n 
A 1 123 LEU 123 158 158 LEU LEU F . n 
A 1 124 HIS 124 159 159 HIS HIS F . n 
A 1 125 LEU 125 160 160 LEU LEU F . n 
A 1 126 GLU 126 161 161 GLU GLU F . n 
A 1 127 GLY 127 162 162 GLY GLY F . n 
A 1 128 GLU 128 163 163 GLU GLU F . n 
A 1 129 VAL 129 164 164 VAL VAL F . n 
A 1 130 ASN 130 165 165 ASN ASN F . n 
A 1 131 LYS 131 166 166 LYS LYS F . n 
A 1 132 ILE 132 167 167 ILE ILE F . n 
A 1 133 LYS 133 168 168 LYS LYS F . n 
A 1 134 SER 134 169 169 SER SER F . n 
A 1 135 ALA 135 170 170 ALA ALA F . n 
A 1 136 LEU 136 171 171 LEU LEU F . n 
A 1 137 LEU 137 172 172 LEU LEU F . n 
A 1 138 SER 138 173 173 SER SER F . n 
A 1 139 THR 139 174 174 THR THR F . n 
A 1 140 ASN 140 175 175 ASN ASN F . n 
A 1 141 LYS 141 176 176 LYS LYS F . n 
A 1 142 ALA 142 177 177 ALA ALA F . n 
A 1 143 VAL 143 178 178 VAL VAL F . n 
A 1 144 VAL 144 179 179 VAL VAL F . n 
A 1 145 SER 145 180 180 SER SER F . n 
A 1 146 LEU 146 181 181 LEU LEU F . n 
A 1 147 SER 147 182 182 SER SER F . n 
A 1 148 ASN 148 183 183 ASN ASN F . n 
A 1 149 GLY 149 184 184 GLY GLY F . n 
A 1 150 VAL 150 185 185 VAL VAL F . n 
A 1 151 SER 151 186 186 SER SER F . n 
A 1 152 VAL 152 187 187 VAL VAL F . n 
A 1 153 LEU 153 188 188 LEU LEU F . n 
A 1 154 THR 154 189 189 THR THR F . n 
A 1 155 SER 155 190 190 SER SER F . n 
A 1 156 LYS 156 191 191 LYS LYS F . n 
A 1 157 VAL 157 192 192 VAL VAL F . n 
A 1 158 LEU 158 193 193 LEU LEU F . n 
A 1 159 ASP 159 194 194 ASP ASP F . n 
A 1 160 LEU 160 195 195 LEU LEU F . n 
A 1 161 LYS 161 196 196 LYS LYS F . n 
A 1 162 ASN 162 197 197 ASN ASN F . n 
A 1 163 TYR 163 198 198 TYR TYR F . n 
A 1 164 ILE 164 199 199 ILE ILE F . n 
A 1 165 ASP 165 200 200 ASP ASP F . n 
A 1 166 LYS 166 201 201 LYS LYS F . n 
A 1 167 GLN 167 202 202 GLN GLN F . n 
A 1 168 LEU 168 203 203 LEU LEU F . n 
A 1 169 LEU 169 204 204 LEU LEU F . n 
A 1 170 PRO 170 205 205 PRO PRO F . n 
A 1 171 ILE 171 206 206 ILE ILE F . n 
A 1 172 VAL 172 207 207 VAL VAL F . n 
A 1 173 ASN 173 208 208 ASN ASN F . n 
A 1 174 LYS 174 209 209 LYS LYS F . n 
A 1 175 GLN 175 210 210 GLN GLN F . n 
A 1 176 SER 176 211 211 SER SER F . n 
A 1 177 CYS 177 212 212 CYS CYS F . n 
A 1 178 SER 178 213 213 SER SER F . n 
A 1 179 ILE 179 214 214 ILE ILE F . n 
A 1 180 PRO 180 215 215 PRO PRO F . n 
A 1 181 ASN 181 216 216 ASN ASN F . n 
A 1 182 ILE 182 217 217 ILE ILE F . n 
A 1 183 GLU 183 218 218 GLU GLU F . n 
A 1 184 THR 184 219 219 THR THR F . n 
A 1 185 VAL 185 220 220 VAL VAL F . n 
A 1 186 ILE 186 221 221 ILE ILE F . n 
A 1 187 GLU 187 222 222 GLU GLU F . n 
A 1 188 PHE 188 223 223 PHE PHE F . n 
A 1 189 GLN 189 224 224 GLN GLN F . n 
A 1 190 GLN 190 225 225 GLN GLN F . n 
A 1 191 LYS 191 226 226 LYS LYS F . n 
A 1 192 ASN 192 227 227 ASN ASN F . n 
A 1 193 ASN 193 228 228 ASN ASN F . n 
A 1 194 ARG 194 229 229 ARG ARG F . n 
A 1 195 LEU 195 230 230 LEU LEU F . n 
A 1 196 LEU 196 231 231 LEU LEU F . n 
A 1 197 GLU 197 232 232 GLU GLU F . n 
A 1 198 ILE 198 233 233 ILE ILE F . n 
A 1 199 THR 199 234 234 THR THR F . n 
A 1 200 ARG 200 235 235 ARG ARG F . n 
A 1 201 GLU 201 236 236 GLU GLU F . n 
A 1 202 PHE 202 237 237 PHE PHE F . n 
A 1 203 SER 203 238 238 SER SER F . n 
A 1 204 VAL 204 239 239 VAL VAL F . n 
A 1 205 ASN 205 240 240 ASN ASN F . n 
A 1 206 ALA 206 241 241 ALA ALA F . n 
A 1 207 GLY 207 242 242 GLY GLY F . n 
A 1 208 VAL 208 243 243 VAL VAL F . n 
A 1 209 THR 209 244 244 THR THR F . n 
A 1 210 THR 210 245 245 THR THR F . n 
A 1 211 PRO 211 246 246 PRO PRO F . n 
A 1 212 VAL 212 247 247 VAL VAL F . n 
A 1 213 SER 213 248 248 SER SER F . n 
A 1 214 THR 214 249 249 THR THR F . n 
A 1 215 TYR 215 250 250 TYR TYR F . n 
A 1 216 MET 216 251 251 MET MET F . n 
A 1 217 LEU 217 252 252 LEU LEU F . n 
A 1 218 THR 218 253 253 THR THR F . n 
A 1 219 ASN 219 254 254 ASN ASN F . n 
A 1 220 SER 220 255 255 SER SER F . n 
A 1 221 GLU 221 256 256 GLU GLU F . n 
A 1 222 LEU 222 257 257 LEU LEU F . n 
A 1 223 LEU 223 258 258 LEU LEU F . n 
A 1 224 SER 224 259 259 SER SER F . n 
A 1 225 LEU 225 260 260 LEU LEU F . n 
A 1 226 ILE 226 261 261 ILE ILE F . n 
A 1 227 ASN 227 262 262 ASN ASN F . n 
A 1 228 ASP 228 263 263 ASP ASP F . n 
A 1 229 MET 229 264 264 MET MET F . n 
A 1 230 PRO 230 265 265 PRO PRO F . n 
A 1 231 ILE 231 266 266 ILE ILE F . n 
A 1 232 THR 232 267 267 THR THR F . n 
A 1 233 ASN 233 268 268 ASN ASN F . n 
A 1 234 ASP 234 269 269 ASP ASP F . n 
A 1 235 GLN 235 270 270 GLN GLN F . n 
A 1 236 LYS 236 271 271 LYS LYS F . n 
A 1 237 LYS 237 272 272 LYS LYS F . n 
A 1 238 LEU 238 273 273 LEU LEU F . n 
A 1 239 MET 239 274 274 MET MET F . n 
A 1 240 SER 240 275 275 SER SER F . n 
A 1 241 ASN 241 276 276 ASN ASN F . n 
A 1 242 ASN 242 277 277 ASN ASN F . n 
A 1 243 VAL 243 278 278 VAL VAL F . n 
A 1 244 GLN 244 279 279 GLN GLN F . n 
A 1 245 ILE 245 280 280 ILE ILE F . n 
A 1 246 VAL 246 281 281 VAL VAL F . n 
A 1 247 ARG 247 282 282 ARG ARG F . n 
A 1 248 GLN 248 283 283 GLN GLN F . n 
A 1 249 GLN 249 284 284 GLN GLN F . n 
A 1 250 SER 250 285 285 SER SER F . n 
A 1 251 TYR 251 286 286 TYR TYR F . n 
A 1 252 SER 252 287 287 SER SER F . n 
A 1 253 ILE 253 288 288 ILE ILE F . n 
A 1 254 MET 254 289 289 MET MET F . n 
A 1 255 CYS 255 290 290 CYS CYS F . n 
A 1 256 ILE 256 291 291 ILE ILE F . n 
A 1 257 ILE 257 292 292 ILE ILE F . n 
A 1 258 LYS 258 293 293 LYS LYS F . n 
A 1 259 GLU 259 294 294 GLU GLU F . n 
A 1 260 GLU 260 295 295 GLU GLU F . n 
A 1 261 VAL 261 296 296 VAL VAL F . n 
A 1 262 LEU 262 297 297 LEU LEU F . n 
A 1 263 ALA 263 298 298 ALA ALA F . n 
A 1 264 TYR 264 299 299 TYR TYR F . n 
A 1 265 VAL 265 300 300 VAL VAL F . n 
A 1 266 VAL 266 301 301 VAL VAL F . n 
A 1 267 GLN 267 302 302 GLN GLN F . n 
A 1 268 LEU 268 303 303 LEU LEU F . n 
A 1 269 PRO 269 304 304 PRO PRO F . n 
A 1 270 LEU 270 305 305 LEU LEU F . n 
A 1 271 TYR 271 306 306 TYR TYR F . n 
A 1 272 GLY 272 307 307 GLY GLY F . n 
A 1 273 VAL 273 308 308 VAL VAL F . n 
A 1 274 ILE 274 309 309 ILE ILE F . n 
A 1 275 ASP 275 310 310 ASP ASP F . n 
A 1 276 THR 276 311 311 THR THR F . n 
A 1 277 PRO 277 312 312 PRO PRO F . n 
A 1 278 CYS 278 313 313 CYS CYS F . n 
A 1 279 TRP 279 314 314 TRP TRP F . n 
A 1 280 LYS 280 315 315 LYS LYS F . n 
A 1 281 LEU 281 316 316 LEU LEU F . n 
A 1 282 HIS 282 317 317 HIS HIS F . n 
A 1 283 THR 283 318 318 THR THR F . n 
A 1 284 SER 284 319 319 SER SER F . n 
A 1 285 PRO 285 320 320 PRO PRO F . n 
A 1 286 LEU 286 321 321 LEU LEU F . n 
A 1 287 CYS 287 322 322 CYS CYS F . n 
A 1 288 THR 288 323 323 THR THR F . n 
A 1 289 THR 289 324 324 THR THR F . n 
A 1 290 ASN 290 325 325 ASN ASN F . n 
A 1 291 THR 291 326 326 THR THR F . n 
A 1 292 LYS 292 327 327 LYS LYS F . n 
A 1 293 GLU 293 328 328 GLU GLU F . n 
A 1 294 GLY 294 329 329 GLY GLY F . n 
A 1 295 SER 295 330 330 SER SER F . n 
A 1 296 ASN 296 331 331 ASN ASN F . n 
A 1 297 ILE 297 332 332 ILE ILE F . n 
A 1 298 CYS 298 333 333 CYS CYS F . n 
A 1 299 LEU 299 334 334 LEU LEU F . n 
A 1 300 THR 300 335 335 THR THR F . n 
A 1 301 ARG 301 336 336 ARG ARG F . n 
A 1 302 THR 302 337 337 THR THR F . n 
A 1 303 ASP 303 338 338 ASP ASP F . n 
A 1 304 ARG 304 339 339 ARG ARG F . n 
A 1 305 GLY 305 340 340 GLY GLY F . n 
A 1 306 TRP 306 341 341 TRP TRP F . n 
A 1 307 TYR 307 342 342 TYR TYR F . n 
A 1 308 CYS 308 343 343 CYS CYS F . n 
A 1 309 ASP 309 344 344 ASP ASP F . n 
A 1 310 ASN 310 345 345 ASN ASN F . n 
A 1 311 ALA 311 346 346 ALA ALA F . n 
A 1 312 GLY 312 347 347 GLY GLY F . n 
A 1 313 SER 313 348 348 SER SER F . n 
A 1 314 VAL 314 349 349 VAL VAL F . n 
A 1 315 SER 315 350 350 SER SER F . n 
A 1 316 PHE 316 351 351 PHE PHE F . n 
A 1 317 PHE 317 352 352 PHE PHE F . n 
A 1 318 PRO 318 353 353 PRO PRO F . n 
A 1 319 GLN 319 354 354 GLN GLN F . n 
A 1 320 ALA 320 355 355 ALA ALA F . n 
A 1 321 GLU 321 356 356 GLU GLU F . n 
A 1 322 THR 322 357 357 THR THR F . n 
A 1 323 CYS 323 358 358 CYS CYS F . n 
A 1 324 LYS 324 359 359 LYS LYS F . n 
A 1 325 VAL 325 360 360 VAL VAL F . n 
A 1 326 GLN 326 361 361 GLN GLN F . n 
A 1 327 SER 327 362 362 SER SER F . n 
A 1 328 ASN 328 363 363 ASN ASN F . n 
A 1 329 ARG 329 364 364 ARG ARG F . n 
A 1 330 VAL 330 365 365 VAL VAL F . n 
A 1 331 PHE 331 366 366 PHE PHE F . n 
A 1 332 CYS 332 367 367 CYS CYS F . n 
A 1 333 ASP 333 368 368 ASP ASP F . n 
A 1 334 THR 334 369 369 THR THR F . n 
A 1 335 MET 335 370 370 MET MET F . n 
A 1 336 ASN 336 371 371 ASN ASN F . n 
A 1 337 SER 337 372 372 SER SER F . n 
A 1 338 LEU 338 373 373 LEU LEU F . n 
A 1 339 THR 339 374 374 THR THR F . n 
A 1 340 LEU 340 375 375 LEU LEU F . n 
A 1 341 PRO 341 376 376 PRO PRO F . n 
A 1 342 SER 342 377 377 SER SER F . n 
A 1 343 GLU 343 378 378 GLU GLU F . n 
A 1 344 VAL 344 379 379 VAL VAL F . n 
A 1 345 ASN 345 380 380 ASN ASN F . n 
A 1 346 LEU 346 381 381 LEU LEU F . n 
A 1 347 CYS 347 382 382 CYS CYS F . n 
A 1 348 ASN 348 383 383 ASN ASN F . n 
A 1 349 VAL 349 384 384 VAL VAL F . n 
A 1 350 ASP 350 385 385 ASP ASP F . n 
A 1 351 ILE 351 386 386 ILE ILE F . n 
A 1 352 PHE 352 387 387 PHE PHE F . n 
A 1 353 ASN 353 388 388 ASN ASN F . n 
A 1 354 PRO 354 389 389 PRO PRO F . n 
A 1 355 LYS 355 390 390 LYS LYS F . n 
A 1 356 TYR 356 391 391 TYR TYR F . n 
A 1 357 ASP 357 392 392 ASP ASP F . n 
A 1 358 CYS 358 393 393 CYS CYS F . n 
A 1 359 LYS 359 394 394 LYS LYS F . n 
A 1 360 ILE 360 395 395 ILE ILE F . n 
A 1 361 MET 361 396 396 MET MET F . n 
A 1 362 THR 362 397 397 THR THR F . n 
A 1 363 SER 363 398 398 SER SER F . n 
A 1 364 LYS 364 399 399 LYS LYS F . n 
A 1 365 THR 365 400 400 THR THR F . n 
A 1 366 ASP 366 401 401 ASP ASP F . n 
A 1 367 VAL 367 402 402 VAL VAL F . n 
A 1 368 SER 368 403 403 SER SER F . n 
A 1 369 SER 369 404 404 SER SER F . n 
A 1 370 SER 370 405 405 SER SER F . n 
A 1 371 VAL 371 406 406 VAL VAL F . n 
A 1 372 ILE 372 407 407 ILE ILE F . n 
A 1 373 THR 373 408 408 THR THR F . n 
A 1 374 SER 374 409 409 SER SER F . n 
A 1 375 LEU 375 410 410 LEU LEU F . n 
A 1 376 GLY 376 411 411 GLY GLY F . n 
A 1 377 ALA 377 412 412 ALA ALA F . n 
A 1 378 ILE 378 413 413 ILE ILE F . n 
A 1 379 VAL 379 414 414 VAL VAL F . n 
A 1 380 SER 380 415 415 SER SER F . n 
A 1 381 CYS 381 416 416 CYS CYS F . n 
A 1 382 TYR 382 417 417 TYR TYR F . n 
A 1 383 GLY 383 418 418 GLY GLY F . n 
A 1 384 LYS 384 419 419 LYS LYS F . n 
A 1 385 THR 385 420 420 THR THR F . n 
A 1 386 LYS 386 421 421 LYS LYS F . n 
A 1 387 CYS 387 422 422 CYS CYS F . n 
A 1 388 THR 388 423 423 THR THR F . n 
A 1 389 ALA 389 424 424 ALA ALA F . n 
A 1 390 SER 390 425 425 SER SER F . n 
A 1 391 ASN 391 426 426 ASN ASN F . n 
A 1 392 LYS 392 427 427 LYS LYS F . n 
A 1 393 ASN 393 428 428 ASN ASN F . n 
A 1 394 ARG 394 429 429 ARG ARG F . n 
A 1 395 GLY 395 430 430 GLY GLY F . n 
A 1 396 ILE 396 431 431 ILE ILE F . n 
A 1 397 ILE 397 432 432 ILE ILE F . n 
A 1 398 LYS 398 433 433 LYS LYS F . n 
A 1 399 THR 399 434 434 THR THR F . n 
A 1 400 PHE 400 435 435 PHE PHE F . n 
A 1 401 SER 401 436 436 SER SER F . n 
A 1 402 ASN 402 437 437 ASN ASN F . n 
A 1 403 GLY 403 438 438 GLY GLY F . n 
A 1 404 CYS 404 439 439 CYS CYS F . n 
A 1 405 ASP 405 440 440 ASP ASP F . n 
A 1 406 TYR 406 441 441 TYR TYR F . n 
A 1 407 VAL 407 442 442 VAL VAL F . n 
A 1 408 SER 408 443 443 SER SER F . n 
A 1 409 ASN 409 444 444 ASN ASN F . n 
A 1 410 LYS 410 445 445 LYS LYS F . n 
A 1 411 GLY 411 446 446 GLY GLY F . n 
A 1 412 VAL 412 447 447 VAL VAL F . n 
A 1 413 ASP 413 448 448 ASP ASP F . n 
A 1 414 THR 414 449 449 THR THR F . n 
A 1 415 VAL 415 450 450 VAL VAL F . n 
A 1 416 SER 416 451 451 SER SER F . n 
A 1 417 VAL 417 452 452 VAL VAL F . n 
A 1 418 GLY 418 453 453 GLY GLY F . n 
A 1 419 ASN 419 454 454 ASN ASN F . n 
A 1 420 THR 420 455 455 THR THR F . n 
A 1 421 LEU 421 456 456 LEU LEU F . n 
A 1 422 TYR 422 457 457 TYR TYR F . n 
A 1 423 CYS 423 458 458 CYS CYS F . n 
A 1 424 VAL 424 459 459 VAL VAL F . n 
A 1 425 ASN 425 460 460 ASN ASN F . n 
A 1 426 LYS 426 461 461 LYS LYS F . n 
A 1 427 GLN 427 462 462 GLN GLN F . n 
A 1 428 GLU 428 463 463 GLU GLU F . n 
A 1 429 GLY 429 464 464 GLY GLY F . n 
A 1 430 GLN 430 465 465 GLN GLN F . n 
A 1 431 SER 431 466 466 SER SER F . n 
A 1 432 LEU 432 467 467 LEU LEU F . n 
A 1 433 TYR 433 468 468 TYR TYR F . n 
A 1 434 VAL 434 469 469 VAL VAL F . n 
A 1 435 LYS 435 470 470 LYS LYS F . n 
A 1 436 GLY 436 471 471 GLY GLY F . n 
A 1 437 GLU 437 472 472 GLU GLU F . n 
A 1 438 PRO 438 473 473 PRO PRO F . n 
A 1 439 ILE 439 474 474 ILE ILE F . n 
A 1 440 ILE 440 475 475 ILE ILE F . n 
A 1 441 ASN 441 476 476 ASN ASN F . n 
A 1 442 PHE 442 477 477 PHE PHE F . n 
A 1 443 TYR 443 478 478 TYR TYR F . n 
A 1 444 ASP 444 479 479 ASP ASP F . n 
A 1 445 PRO 445 480 480 PRO PRO F . n 
A 1 446 LEU 446 481 481 LEU LEU F . n 
A 1 447 VAL 447 482 482 VAL VAL F . n 
A 1 448 PHE 448 483 483 PHE PHE F . n 
A 1 449 PRO 449 484 484 PRO PRO F . n 
A 1 450 SER 450 485 485 SER SER F . n 
A 1 451 ASP 451 486 486 ASP ASP F . n 
A 1 452 GLU 452 487 487 GLU GLU F . n 
A 1 453 PHE 453 488 488 PHE PHE F . n 
A 1 454 ASP 454 489 489 ASP ASP F . n 
A 1 455 ALA 455 490 490 ALA ALA F . n 
A 1 456 SER 456 491 491 SER SER F . n 
A 1 457 ILE 457 492 492 ILE ILE F . n 
A 1 458 SER 458 493 493 SER SER F . n 
A 1 459 GLN 459 494 494 GLN GLN F . n 
A 1 460 VAL 460 495 495 VAL VAL F . n 
A 1 461 ASN 461 496 496 ASN ASN F . n 
A 1 462 GLU 462 497 497 GLU GLU F . n 
A 1 463 LYS 463 498 498 LYS LYS F . n 
A 1 464 ILE 464 499 499 ILE ILE F . n 
A 1 465 ASN 465 500 500 ASN ASN F . n 
A 1 466 GLN 466 501 501 GLN GLN F . n 
A 1 467 SER 467 502 502 SER SER F . n 
A 1 468 LEU 468 503 503 LEU LEU F . n 
A 1 469 ALA 469 504 504 ALA ALA F . n 
A 1 470 PHE 470 505 505 PHE PHE F . n 
A 1 471 ILE 471 506 506 ILE ILE F . n 
A 1 472 ARG 472 507 507 ARG ARG F . n 
A 1 473 LYS 473 508 508 LYS LYS F . n 
A 1 474 SER 474 509 509 SER SER F . n 
A 1 475 ASP 475 510 ?   ?   ?   F . n 
A 1 476 GLU 476 511 ?   ?   ?   F . n 
A 1 477 LEU 477 512 ?   ?   ?   F . n 
A 1 478 LEU 478 513 ?   ?   ?   F . n 
A 1 479 ALA 479 514 ?   ?   ?   F . n 
A 1 480 SER 480 515 ?   ?   ?   F . n 
A 1 481 GLY 481 516 ?   ?   ?   F . n 
A 1 482 TYR 482 517 ?   ?   ?   F . n 
A 1 483 ILE 483 518 ?   ?   ?   F . n 
A 1 484 PRO 484 519 ?   ?   ?   F . n 
A 1 485 GLU 485 520 ?   ?   ?   F . n 
A 1 486 ALA 486 521 ?   ?   ?   F . n 
A 1 487 PRO 487 522 ?   ?   ?   F . n 
A 1 488 ARG 488 523 ?   ?   ?   F . n 
A 1 489 ASP 489 524 ?   ?   ?   F . n 
A 1 490 GLY 490 525 ?   ?   ?   F . n 
A 1 491 GLN 491 526 ?   ?   ?   F . n 
A 1 492 ALA 492 527 ?   ?   ?   F . n 
A 1 493 TYR 493 528 ?   ?   ?   F . n 
A 1 494 VAL 494 529 ?   ?   ?   F . n 
A 1 495 ARG 495 530 ?   ?   ?   F . n 
A 1 496 LYS 496 531 ?   ?   ?   F . n 
A 1 497 ASP 497 532 ?   ?   ?   F . n 
A 1 498 GLY 498 533 ?   ?   ?   F . n 
A 1 499 GLU 499 534 ?   ?   ?   F . n 
A 1 500 TRP 500 535 ?   ?   ?   F . n 
A 1 501 VAL 501 536 ?   ?   ?   F . n 
A 1 502 LEU 502 537 ?   ?   ?   F . n 
A 1 503 LEU 503 538 ?   ?   ?   F . n 
A 1 504 SER 504 539 ?   ?   ?   F . n 
A 1 505 THR 505 540 ?   ?   ?   F . n 
A 1 506 PHE 506 541 ?   ?   ?   F . n 
A 1 507 LEU 507 542 ?   ?   ?   F . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 EDO 1  601 540 EDO EDO F . 
C 3 NAG 1  602 541 NAG NAG F . 
D 4 HOH 1  701 1   HOH HOH F . 
D 4 HOH 2  702 8   HOH HOH F . 
D 4 HOH 3  703 2   HOH HOH F . 
D 4 HOH 4  704 11  HOH HOH F . 
D 4 HOH 5  705 5   HOH HOH F . 
D 4 HOH 6  706 10  HOH HOH F . 
D 4 HOH 7  707 7   HOH HOH F . 
D 4 HOH 8  708 6   HOH HOH F . 
D 4 HOH 9  709 4   HOH HOH F . 
D 4 HOH 10 710 12  HOH HOH F . 
D 4 HOH 11 711 9   HOH HOH F . 
D 4 HOH 12 712 3   HOH HOH F . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W3J 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     169.220 
_cell.length_a_esd                 ? 
_cell.length_b                     169.220 
_cell.length_b_esd                 ? 
_cell.length_c                     169.220 
_cell.length_c_esd                 ? 
_cell.volume                       4845683.809 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W3J 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                213 
_symmetry.space_group_name_Hall            'P 4bd 2ab 3' 
_symmetry.space_group_name_H-M             'P 41 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8W3J 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.63 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          66.10 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Potassium Sodium tartrate, 20% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-11-22 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          50.36 
_reflns.entry_id                                       8W3J 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.83 
_reflns.d_resolution_low                               37.84 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     20350 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.81 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                30.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          22.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.83 
_reflns_shell.d_res_low                                     2.93 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1986 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.813 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               54.45 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8W3J 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.83 
_refine.ls_d_res_low                             37.84 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20350 
_refine.ls_number_reflns_R_free                  1025 
_refine.ls_number_reflns_R_work                  19325 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.90 
_refine.ls_percent_reflns_R_free                 5.04 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2260 
_refine.ls_R_factor_R_free                       0.2581 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2243 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.7718 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2753 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.83 
_refine_hist.d_res_low                        37.84 
_refine_hist.number_atoms_solvent             12 
_refine_hist.number_atoms_total               3456 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3426 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         18 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0110  ? 3492 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.4611  ? 4733 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0817  ? 575  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0138  ? 597  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.2104 ? 1297 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.83 2.98  . . 149 2689 99.82  . . . . 0.2886 . . . . . . . . . . . 0.3198 
'X-RAY DIFFRACTION' 2.98 3.16  . . 138 2703 100.00 . . . . 0.2642 . . . . . . . . . . . 0.2768 
'X-RAY DIFFRACTION' 3.16 3.41  . . 133 2726 99.93  . . . . 0.2644 . . . . . . . . . . . 0.3018 
'X-RAY DIFFRACTION' 3.41 3.75  . . 135 2729 99.90  . . . . 0.2379 . . . . . . . . . . . 0.2831 
'X-RAY DIFFRACTION' 3.75 4.29  . . 137 2748 99.72  . . . . 0.2275 . . . . . . . . . . . 0.2812 
'X-RAY DIFFRACTION' 4.29 5.41  . . 160 2781 99.93  . . . . 0.1904 . . . . . . . . . . . 0.2428 
'X-RAY DIFFRACTION' 5.41 37.84 . . 173 2949 99.97  . . . . 0.1969 . . . . . . . . . . . 0.2096 
# 
_struct.entry_id                     8W3J 
_struct.title                        'Crystal structure of prefusion-stabilized RSV F protein UFCR2-iSS' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W3J 
_struct_keywords.text            'Respiratory syncytial virus, glycoprotein, prefusion vaccine, stabilized, viral protein' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8W3J 
_struct_ref.pdbx_db_accession          8W3J 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8W3J 
_struct_ref_seq.pdbx_strand_id                F 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 507 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8W3J 
_struct_ref_seq.db_align_beg                  -3 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  542 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -3 
_struct_ref_seq.pdbx_auth_seq_align_end       542 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 12110 ? 
1 MORE         -25   ? 
1 'SSA (A^2)'  54470 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000 0.0000000000 0.0000000000 0.0000000000    0.0000000000 1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000    
2 'crystal symmetry operation' 5_663 z+1,x+1,y-2 0.0000000000 0.0000000000 1.0000000000 169.2200000000  1.0000000000 0.0000000000 
0.0000000000 169.2200000000 0.0000000000 1.0000000000 0.0000000000 -338.4400000000 
3 'crystal symmetry operation' 9_474 y-1,z+2,x-1 0.0000000000 1.0000000000 0.0000000000 -169.2200000000 0.0000000000 0.0000000000 
1.0000000000 338.4400000000 1.0000000000 0.0000000000 0.0000000000 -169.2200000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 77  ? SER A 103 ? ASP F 73  SER F 99  1 ? 27 
HELX_P HELX_P2  AA2 SER A 109 ? ALA A 112 ? SER F 144 ALA F 147 5 ? 4  
HELX_P HELX_P3  AA3 ILE A 113 ? HIS A 124 ? ILE F 148 HIS F 159 1 ? 12 
HELX_P HELX_P4  AA4 GLY A 127 ? LEU A 136 ? GLY F 162 LEU F 171 1 ? 10 
HELX_P HELX_P5  AA5 SER A 147 ? GLY A 149 ? SER F 182 GLY F 184 5 ? 3  
HELX_P HELX_P6  AA6 LEU A 160 ? LEU A 168 ? LEU F 195 LEU F 203 1 ? 9  
HELX_P HELX_P7  AA7 LEU A 168 ? ASN A 173 ? LEU F 203 ASN F 208 1 ? 6  
HELX_P HELX_P8  AA8 ASN A 181 ? ASN A 205 ? ASN F 216 ASN F 240 1 ? 25 
HELX_P HELX_P9  AA9 THR A 218 ? ASP A 228 ? THR F 253 ASP F 263 1 ? 11 
HELX_P HELX_P10 AB1 THR A 232 ? ASN A 241 ? THR F 267 ASN F 276 1 ? 10 
HELX_P HELX_P11 AB2 ASN A 242 ? GLN A 249 ? ASN F 277 GLN F 284 1 ? 8  
HELX_P HELX_P12 AB3 GLN A 319 ? GLU A 321 ? GLN F 354 GLU F 356 5 ? 3  
HELX_P HELX_P13 AB4 MET A 335 ? SER A 337 ? MET F 370 SER F 372 5 ? 3  
HELX_P HELX_P14 AB5 GLU A 343 ? VAL A 349 ? GLU F 378 VAL F 384 5 ? 7  
HELX_P HELX_P15 AB6 PRO A 438 ? TYR A 443 ? PRO F 473 TYR F 478 5 ? 6  
HELX_P HELX_P16 AB7 ASP A 444 ? PHE A 448 ? ASP F 479 PHE F 483 5 ? 5  
HELX_P HELX_P17 AB8 ILE A 457 ? LYS A 473 ? ILE F 492 LYS F 508 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 41  SG  ? ? ? 1_555 A CYS 404 SG ? ? F CYS 37  F CYS 439 1_555 ? ? ? ? ? ? ? 2.030 ? ?               
disulf2 disulf ?   ? A CYS 73  SG  ? ? ? 1_555 A CYS 177 SG ? ? F CYS 69  F CYS 212 1_555 ? ? ? ? ? ? ? 2.044 ? ?               
disulf3 disulf ?   ? A CYS 114 SG  ? ? ? 1_555 A CYS 423 SG ? ? F CYS 149 F CYS 458 5_663 ? ? ? ? ? ? ? 2.032 ? ?               
disulf4 disulf ?   ? A CYS 120 SG  ? ? ? 1_555 A CYS 255 SG ? ? F CYS 155 F CYS 290 1_555 ? ? ? ? ? ? ? 2.060 ? ?               
disulf5 disulf ?   ? A CYS 278 SG  ? ? ? 1_555 A CYS 308 SG ? ? F CYS 313 F CYS 343 1_555 ? ? ? ? ? ? ? 2.044 ? ?               
disulf6 disulf ?   ? A CYS 287 SG  ? ? ? 1_555 A CYS 298 SG ? ? F CYS 322 F CYS 333 1_555 ? ? ? ? ? ? ? 2.025 ? ?               
disulf7 disulf ?   ? A CYS 323 SG  ? ? ? 1_555 A CYS 332 SG ? ? F CYS 358 F CYS 367 1_555 ? ? ? ? ? ? ? 2.095 ? ?               
disulf8 disulf ?   ? A CYS 347 SG  ? ? ? 1_555 A CYS 358 SG ? ? F CYS 382 F CYS 393 1_555 ? ? ? ? ? ? ? 2.068 ? ?               
disulf9 disulf ?   ? A CYS 381 SG  ? ? ? 1_555 A CYS 387 SG ? ? F CYS 416 F CYS 422 1_555 ? ? ? ? ? ? ? 2.094 ? ?               
covale1 covale one ? A ASN 465 ND2 ? ? ? 1_555 C NAG .   C1 ? ? F ASN 500 F NAG 602 1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG C .   ? ASN A 465 ? NAG F 602 ? 1_555 ASN F 500 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  CYS A 41  ? CYS A 404 ? CYS F 37  ? 1_555 CYS F 439 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3  CYS A 73  ? CYS A 177 ? CYS F 69  ? 1_555 CYS F 212 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4  CYS A 114 ? CYS A 423 ? CYS F 149 ? 1_555 CYS F 458 ? 5_663 SG SG  .   . .   None            'Disulfide bridge' 
5  CYS A 120 ? CYS A 255 ? CYS F 155 ? 1_555 CYS F 290 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6  CYS A 278 ? CYS A 308 ? CYS F 313 ? 1_555 CYS F 343 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7  CYS A 287 ? CYS A 298 ? CYS F 322 ? 1_555 CYS F 333 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS A 323 ? CYS A 332 ? CYS F 358 ? 1_555 CYS F 367 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS A 347 ? CYS A 358 ? CYS F 382 ? 1_555 CYS F 393 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS A 381 ? CYS A 387 ? CYS F 416 ? 1_555 CYS F 422 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          THR 
_struct_mon_prot_cis.label_seq_id           210 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           THR 
_struct_mon_prot_cis.auth_seq_id            245 
_struct_mon_prot_cis.auth_asym_id           F 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    211 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     246 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    F 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.30 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 6 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? parallel      
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA1 2 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA1 3 SER A 42  ? ARG A 53  ? SER F 38  ARG F 49  
AA1 4 VAL A 273 ? THR A 283 ? VAL F 308 THR F 318 
AA1 5 GLY A 305 ? ASN A 310 ? GLY F 340 ASN F 345 
AA1 6 SER A 313 ? PHE A 317 ? SER F 348 PHE F 352 
AA1 7 LEU A 338 ? PRO A 341 ? LEU F 373 PRO F 376 
AA2 1 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA2 2 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA2 3 SER A 42  ? ARG A 53  ? SER F 38  ARG F 49  
AA2 4 THR A 33  ? TYR A 37  ? THR F 29  TYR F 33  
AA2 5 GLN A 430 ? VAL A 434 ? GLN F 465 VAL F 469 
AA3 1 LYS A 141 ? SER A 145 ? LYS F 176 SER F 180 
AA3 2 SER A 151 ? ASP A 159 ? SER F 186 ASP F 194 
AA3 3 GLY A 55  ? GLU A 64  ? GLY F 51  GLU F 60  
AA3 4 VAL A 261 ? LEU A 270 ? VAL F 296 LEU F 305 
AA3 5 TYR A 251 ? ILE A 257 ? TYR F 286 ILE F 292 
AA3 6 VAL A 208 ? THR A 209 ? VAL F 243 THR F 244 
AA4 1 LEU A 286 ? CYS A 287 ? LEU F 321 CYS F 322 
AA4 2 CYS A 298 ? ARG A 301 ? CYS F 333 ARG F 336 
AA4 3 LYS A 359 ? SER A 363 ? LYS F 394 SER F 398 
AA4 4 ALA A 455 ? SER A 456 ? ALA F 490 SER F 491 
AA5 1 SER A 369 ? ILE A 372 ? SER F 404 ILE F 407 
AA5 2 GLY A 376 ? CYS A 381 ? GLY F 411 CYS F 416 
AA5 3 GLY A 403 ? SER A 408 ? GLY F 438 SER F 443 
AA6 1 GLY A 395 ? THR A 399 ? GLY F 430 THR F 434 
AA6 2 CYS A 387 ? ASN A 391 ? CYS F 422 ASN F 426 
AA6 3 THR A 414 ? VAL A 417 ? THR F 449 VAL F 452 
AA6 4 THR A 420 ? CYS A 423 ? THR F 455 CYS F 458 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LYS A 324 ? N LYS F 359 O PHE A 331 ? O PHE F 366 
AA1 2 3 O VAL A 330 ? O VAL F 365 N ALA A 51  ? N ALA F 47  
AA1 3 4 N GLY A 50  ? N GLY F 46  O THR A 276 ? O THR F 311 
AA1 4 5 N TRP A 279 ? N TRP F 314 O TYR A 307 ? O TYR F 342 
AA1 5 6 N CYS A 308 ? N CYS F 343 O SER A 315 ? O SER F 350 
AA1 6 7 N VAL A 314 ? N VAL F 349 O LEU A 340 ? O LEU F 375 
AA2 1 2 N LYS A 324 ? N LYS F 359 O PHE A 331 ? O PHE F 366 
AA2 2 3 O VAL A 330 ? O VAL F 365 N ALA A 51  ? N ALA F 47  
AA2 3 4 O SER A 42  ? O SER F 38  N TYR A 37  ? N TYR F 33  
AA2 4 5 N PHE A 36  ? N PHE F 32  O VAL A 434 ? O VAL F 469 
AA3 1 2 N VAL A 144 ? N VAL F 179 O VAL A 152 ? O VAL F 187 
AA3 2 3 O SER A 155 ? O SER F 190 N THR A 62  ? N THR F 58  
AA3 3 4 N TYR A 57  ? N TYR F 53  O LEU A 268 ? O LEU F 303 
AA3 4 5 O VAL A 265 ? O VAL F 300 N ILE A 253 ? N ILE F 288 
AA3 5 6 O SER A 252 ? O SER F 287 N THR A 209 ? N THR F 244 
AA4 1 2 N LEU A 286 ? N LEU F 321 O LEU A 299 ? O LEU F 334 
AA4 2 3 N THR A 300 ? N THR F 335 O MET A 361 ? O MET F 396 
AA4 3 4 N ILE A 360 ? N ILE F 395 O ALA A 455 ? O ALA F 490 
AA5 1 2 N SER A 369 ? N SER F 404 O SER A 380 ? O SER F 415 
AA5 2 3 N VAL A 379 ? N VAL F 414 O ASP A 405 ? O ASP F 440 
AA6 1 2 O ILE A 397 ? O ILE F 432 N ALA A 389 ? N ALA F 424 
AA6 2 3 N THR A 388 ? N THR F 423 O SER A 416 ? O SER F 451 
AA6 3 4 N VAL A 415 ? N VAL F 450 O TYR A 422 ? O TYR F 457 
# 
_pdbx_entry_details.entry_id                   8W3J 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   NZ 
_pdbx_validate_close_contact.auth_asym_id_1   F 
_pdbx_validate_close_contact.auth_comp_id_1   LYS 
_pdbx_validate_close_contact.auth_seq_id_1    166 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   F 
_pdbx_validate_close_contact.auth_comp_id_2   SER 
_pdbx_validate_close_contact.auth_seq_id_2    180 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.01 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN F 70  ? ? -59.01  106.70  
2  1 THR F 72  ? ? -144.56 -32.48  
3  1 LEU F 171 ? ? -93.10  33.71   
4  1 ALA F 177 ? ? -170.11 142.23  
5  1 ASN F 183 ? ? 85.14   13.04   
6  1 CYS F 290 ? ? -95.13  -102.02 
7  1 SER F 362 ? ? 53.41   -140.83 
8  1 ASN F 363 ? ? -65.78  5.25    
9  1 ASN F 371 ? ? -116.38 64.23   
10 1 ASP F 489 ? ? -152.76 58.89   
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    F 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     712 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   D 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  x+1/4,-z+1/4,y+3/4   
3  x+3/4,z+1/4,-y+1/4   
4  z+3/4,y+1/4,-x+1/4   
5  -z+1/4,y+3/4,x+1/4   
6  -y+1/4,x+3/4,z+1/4   
7  y+1/4,-x+1/4,z+3/4   
8  z,x,y                
9  y,z,x                
10 -y+1/2,-z,x+1/2      
11 z+1/2,-x+1/2,-y      
12 -y,z+1/2,-x+1/2      
13 -z+1/2,-x,y+1/2      
14 -z,x+1/2,-y+1/2      
15 y+1/2,-z+1/2,-x      
16 x+1/2,-y+1/2,-z      
17 -x,y+1/2,-z+1/2      
18 -x+1/2,-y,z+1/2      
19 y+3/4,x+1/4,-z+1/4   
20 -y+3/4,-x+3/4,-z+3/4 
21 z+1/4,-y+1/4,x+3/4   
22 -z+3/4,-y+3/4,-x+3/4 
23 -x+1/4,z+3/4,y+1/4   
24 -x+3/4,-z+3/4,-y+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 F MET -3  ? A MET 1   
2  1 Y 1 F GLY -2  ? A GLY 2   
3  1 Y 1 F ILE -1  ? A ILE 3   
4  1 Y 1 F LEU 0   ? A LEU 4   
5  1 Y 1 F PRO 1   ? A PRO 5   
6  1 Y 1 F SER 2   ? A SER 6   
7  1 Y 1 F PRO 3   ? A PRO 7   
8  1 Y 1 F GLY 4   ? A GLY 8   
9  1 Y 1 F MET 5   ? A MET 9   
10 1 Y 1 F PRO 6   ? A PRO 10  
11 1 Y 1 F ALA 7   ? A ALA 11  
12 1 Y 1 F LEU 8   ? A LEU 12  
13 1 Y 1 F LEU 9   ? A LEU 13  
14 1 Y 1 F SER 10  ? A SER 14  
15 1 Y 1 F LEU 11  ? A LEU 15  
16 1 Y 1 F VAL 12  ? A VAL 16  
17 1 Y 1 F SER 13  ? A SER 17  
18 1 Y 1 F LEU 14  ? A LEU 18  
19 1 Y 1 F LEU 15  ? A LEU 19  
20 1 Y 1 F SER 16  ? A SER 20  
21 1 Y 1 F VAL 17  ? A VAL 21  
22 1 Y 1 F LEU 18  ? A LEU 22  
23 1 Y 1 F LEU 19  ? A LEU 23  
24 1 Y 1 F MET 20  ? A MET 24  
25 1 Y 1 F GLY 21  ? A GLY 25  
26 1 Y 1 F CYS 22  ? A CYS 26  
27 1 Y 1 F VAL 23  ? A VAL 27  
28 1 Y 1 F ALA 24  ? A ALA 28  
29 1 Y 1 F GLU 25  ? A GLU 29  
30 1 Y 1 F ASP 510 ? A ASP 475 
31 1 Y 1 F GLU 511 ? A GLU 476 
32 1 Y 1 F LEU 512 ? A LEU 477 
33 1 Y 1 F LEU 513 ? A LEU 478 
34 1 Y 1 F ALA 514 ? A ALA 479 
35 1 Y 1 F SER 515 ? A SER 480 
36 1 Y 1 F GLY 516 ? A GLY 481 
37 1 Y 1 F TYR 517 ? A TYR 482 
38 1 Y 1 F ILE 518 ? A ILE 483 
39 1 Y 1 F PRO 519 ? A PRO 484 
40 1 Y 1 F GLU 520 ? A GLU 485 
41 1 Y 1 F ALA 521 ? A ALA 486 
42 1 Y 1 F PRO 522 ? A PRO 487 
43 1 Y 1 F ARG 523 ? A ARG 488 
44 1 Y 1 F ASP 524 ? A ASP 489 
45 1 Y 1 F GLY 525 ? A GLY 490 
46 1 Y 1 F GLN 526 ? A GLN 491 
47 1 Y 1 F ALA 527 ? A ALA 492 
48 1 Y 1 F TYR 528 ? A TYR 493 
49 1 Y 1 F VAL 529 ? A VAL 494 
50 1 Y 1 F ARG 530 ? A ARG 495 
51 1 Y 1 F LYS 531 ? A LYS 496 
52 1 Y 1 F ASP 532 ? A ASP 497 
53 1 Y 1 F GLY 533 ? A GLY 498 
54 1 Y 1 F GLU 534 ? A GLU 499 
55 1 Y 1 F TRP 535 ? A TRP 500 
56 1 Y 1 F VAL 536 ? A VAL 501 
57 1 Y 1 F LEU 537 ? A LEU 502 
58 1 Y 1 F LEU 538 ? A LEU 503 
59 1 Y 1 F SER 539 ? A SER 504 
60 1 Y 1 F THR 540 ? A THR 505 
61 1 Y 1 F PHE 541 ? A PHE 506 
62 1 Y 1 F LEU 542 ? A LEU 507 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EDO C1   C N N 88  
EDO O1   O N N 89  
EDO C2   C N N 90  
EDO O2   O N N 91  
EDO H11  H N N 92  
EDO H12  H N N 93  
EDO HO1  H N N 94  
EDO H21  H N N 95  
EDO H22  H N N 96  
EDO HO2  H N N 97  
GLN N    N N N 98  
GLN CA   C N S 99  
GLN C    C N N 100 
GLN O    O N N 101 
GLN CB   C N N 102 
GLN CG   C N N 103 
GLN CD   C N N 104 
GLN OE1  O N N 105 
GLN NE2  N N N 106 
GLN OXT  O N N 107 
GLN H    H N N 108 
GLN H2   H N N 109 
GLN HA   H N N 110 
GLN HB2  H N N 111 
GLN HB3  H N N 112 
GLN HG2  H N N 113 
GLN HG3  H N N 114 
GLN HE21 H N N 115 
GLN HE22 H N N 116 
GLN HXT  H N N 117 
GLU N    N N N 118 
GLU CA   C N S 119 
GLU C    C N N 120 
GLU O    O N N 121 
GLU CB   C N N 122 
GLU CG   C N N 123 
GLU CD   C N N 124 
GLU OE1  O N N 125 
GLU OE2  O N N 126 
GLU OXT  O N N 127 
GLU H    H N N 128 
GLU H2   H N N 129 
GLU HA   H N N 130 
GLU HB2  H N N 131 
GLU HB3  H N N 132 
GLU HG2  H N N 133 
GLU HG3  H N N 134 
GLU HE2  H N N 135 
GLU HXT  H N N 136 
GLY N    N N N 137 
GLY CA   C N N 138 
GLY C    C N N 139 
GLY O    O N N 140 
GLY OXT  O N N 141 
GLY H    H N N 142 
GLY H2   H N N 143 
GLY HA2  H N N 144 
GLY HA3  H N N 145 
GLY HXT  H N N 146 
HIS N    N N N 147 
HIS CA   C N S 148 
HIS C    C N N 149 
HIS O    O N N 150 
HIS CB   C N N 151 
HIS CG   C Y N 152 
HIS ND1  N Y N 153 
HIS CD2  C Y N 154 
HIS CE1  C Y N 155 
HIS NE2  N Y N 156 
HIS OXT  O N N 157 
HIS H    H N N 158 
HIS H2   H N N 159 
HIS HA   H N N 160 
HIS HB2  H N N 161 
HIS HB3  H N N 162 
HIS HD1  H N N 163 
HIS HD2  H N N 164 
HIS HE1  H N N 165 
HIS HE2  H N N 166 
HIS HXT  H N N 167 
HOH O    O N N 168 
HOH H1   H N N 169 
HOH H2   H N N 170 
ILE N    N N N 171 
ILE CA   C N S 172 
ILE C    C N N 173 
ILE O    O N N 174 
ILE CB   C N S 175 
ILE CG1  C N N 176 
ILE CG2  C N N 177 
ILE CD1  C N N 178 
ILE OXT  O N N 179 
ILE H    H N N 180 
ILE H2   H N N 181 
ILE HA   H N N 182 
ILE HB   H N N 183 
ILE HG12 H N N 184 
ILE HG13 H N N 185 
ILE HG21 H N N 186 
ILE HG22 H N N 187 
ILE HG23 H N N 188 
ILE HD11 H N N 189 
ILE HD12 H N N 190 
ILE HD13 H N N 191 
ILE HXT  H N N 192 
LEU N    N N N 193 
LEU CA   C N S 194 
LEU C    C N N 195 
LEU O    O N N 196 
LEU CB   C N N 197 
LEU CG   C N N 198 
LEU CD1  C N N 199 
LEU CD2  C N N 200 
LEU OXT  O N N 201 
LEU H    H N N 202 
LEU H2   H N N 203 
LEU HA   H N N 204 
LEU HB2  H N N 205 
LEU HB3  H N N 206 
LEU HG   H N N 207 
LEU HD11 H N N 208 
LEU HD12 H N N 209 
LEU HD13 H N N 210 
LEU HD21 H N N 211 
LEU HD22 H N N 212 
LEU HD23 H N N 213 
LEU HXT  H N N 214 
LYS N    N N N 215 
LYS CA   C N S 216 
LYS C    C N N 217 
LYS O    O N N 218 
LYS CB   C N N 219 
LYS CG   C N N 220 
LYS CD   C N N 221 
LYS CE   C N N 222 
LYS NZ   N N N 223 
LYS OXT  O N N 224 
LYS H    H N N 225 
LYS H2   H N N 226 
LYS HA   H N N 227 
LYS HB2  H N N 228 
LYS HB3  H N N 229 
LYS HG2  H N N 230 
LYS HG3  H N N 231 
LYS HD2  H N N 232 
LYS HD3  H N N 233 
LYS HE2  H N N 234 
LYS HE3  H N N 235 
LYS HZ1  H N N 236 
LYS HZ2  H N N 237 
LYS HZ3  H N N 238 
LYS HXT  H N N 239 
MET N    N N N 240 
MET CA   C N S 241 
MET C    C N N 242 
MET O    O N N 243 
MET CB   C N N 244 
MET CG   C N N 245 
MET SD   S N N 246 
MET CE   C N N 247 
MET OXT  O N N 248 
MET H    H N N 249 
MET H2   H N N 250 
MET HA   H N N 251 
MET HB2  H N N 252 
MET HB3  H N N 253 
MET HG2  H N N 254 
MET HG3  H N N 255 
MET HE1  H N N 256 
MET HE2  H N N 257 
MET HE3  H N N 258 
MET HXT  H N N 259 
NAG C1   C N R 260 
NAG C2   C N R 261 
NAG C3   C N R 262 
NAG C4   C N S 263 
NAG C5   C N R 264 
NAG C6   C N N 265 
NAG C7   C N N 266 
NAG C8   C N N 267 
NAG N2   N N N 268 
NAG O1   O N N 269 
NAG O3   O N N 270 
NAG O4   O N N 271 
NAG O5   O N N 272 
NAG O6   O N N 273 
NAG O7   O N N 274 
NAG H1   H N N 275 
NAG H2   H N N 276 
NAG H3   H N N 277 
NAG H4   H N N 278 
NAG H5   H N N 279 
NAG H61  H N N 280 
NAG H62  H N N 281 
NAG H81  H N N 282 
NAG H82  H N N 283 
NAG H83  H N N 284 
NAG HN2  H N N 285 
NAG HO1  H N N 286 
NAG HO3  H N N 287 
NAG HO4  H N N 288 
NAG HO6  H N N 289 
PHE N    N N N 290 
PHE CA   C N S 291 
PHE C    C N N 292 
PHE O    O N N 293 
PHE CB   C N N 294 
PHE CG   C Y N 295 
PHE CD1  C Y N 296 
PHE CD2  C Y N 297 
PHE CE1  C Y N 298 
PHE CE2  C Y N 299 
PHE CZ   C Y N 300 
PHE OXT  O N N 301 
PHE H    H N N 302 
PHE H2   H N N 303 
PHE HA   H N N 304 
PHE HB2  H N N 305 
PHE HB3  H N N 306 
PHE HD1  H N N 307 
PHE HD2  H N N 308 
PHE HE1  H N N 309 
PHE HE2  H N N 310 
PHE HZ   H N N 311 
PHE HXT  H N N 312 
PRO N    N N N 313 
PRO CA   C N S 314 
PRO C    C N N 315 
PRO O    O N N 316 
PRO CB   C N N 317 
PRO CG   C N N 318 
PRO CD   C N N 319 
PRO OXT  O N N 320 
PRO H    H N N 321 
PRO HA   H N N 322 
PRO HB2  H N N 323 
PRO HB3  H N N 324 
PRO HG2  H N N 325 
PRO HG3  H N N 326 
PRO HD2  H N N 327 
PRO HD3  H N N 328 
PRO HXT  H N N 329 
SER N    N N N 330 
SER CA   C N S 331 
SER C    C N N 332 
SER O    O N N 333 
SER CB   C N N 334 
SER OG   O N N 335 
SER OXT  O N N 336 
SER H    H N N 337 
SER H2   H N N 338 
SER HA   H N N 339 
SER HB2  H N N 340 
SER HB3  H N N 341 
SER HG   H N N 342 
SER HXT  H N N 343 
THR N    N N N 344 
THR CA   C N S 345 
THR C    C N N 346 
THR O    O N N 347 
THR CB   C N R 348 
THR OG1  O N N 349 
THR CG2  C N N 350 
THR OXT  O N N 351 
THR H    H N N 352 
THR H2   H N N 353 
THR HA   H N N 354 
THR HB   H N N 355 
THR HG1  H N N 356 
THR HG21 H N N 357 
THR HG22 H N N 358 
THR HG23 H N N 359 
THR HXT  H N N 360 
TRP N    N N N 361 
TRP CA   C N S 362 
TRP C    C N N 363 
TRP O    O N N 364 
TRP CB   C N N 365 
TRP CG   C Y N 366 
TRP CD1  C Y N 367 
TRP CD2  C Y N 368 
TRP NE1  N Y N 369 
TRP CE2  C Y N 370 
TRP CE3  C Y N 371 
TRP CZ2  C Y N 372 
TRP CZ3  C Y N 373 
TRP CH2  C Y N 374 
TRP OXT  O N N 375 
TRP H    H N N 376 
TRP H2   H N N 377 
TRP HA   H N N 378 
TRP HB2  H N N 379 
TRP HB3  H N N 380 
TRP HD1  H N N 381 
TRP HE1  H N N 382 
TRP HE3  H N N 383 
TRP HZ2  H N N 384 
TRP HZ3  H N N 385 
TRP HH2  H N N 386 
TRP HXT  H N N 387 
TYR N    N N N 388 
TYR CA   C N S 389 
TYR C    C N N 390 
TYR O    O N N 391 
TYR CB   C N N 392 
TYR CG   C Y N 393 
TYR CD1  C Y N 394 
TYR CD2  C Y N 395 
TYR CE1  C Y N 396 
TYR CE2  C Y N 397 
TYR CZ   C Y N 398 
TYR OH   O N N 399 
TYR OXT  O N N 400 
TYR H    H N N 401 
TYR H2   H N N 402 
TYR HA   H N N 403 
TYR HB2  H N N 404 
TYR HB3  H N N 405 
TYR HD1  H N N 406 
TYR HD2  H N N 407 
TYR HE1  H N N 408 
TYR HE2  H N N 409 
TYR HH   H N N 410 
TYR HXT  H N N 411 
VAL N    N N N 412 
VAL CA   C N S 413 
VAL C    C N N 414 
VAL O    O N N 415 
VAL CB   C N N 416 
VAL CG1  C N N 417 
VAL CG2  C N N 418 
VAL OXT  O N N 419 
VAL H    H N N 420 
VAL H2   H N N 421 
VAL HA   H N N 422 
VAL HB   H N N 423 
VAL HG11 H N N 424 
VAL HG12 H N N 425 
VAL HG13 H N N 426 
VAL HG21 H N N 427 
VAL HG22 H N N 428 
VAL HG23 H N N 429 
VAL HXT  H N N 430 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
NAG C1  C2   sing N N 246 
NAG C1  O1   sing N N 247 
NAG C1  O5   sing N N 248 
NAG C1  H1   sing N N 249 
NAG C2  C3   sing N N 250 
NAG C2  N2   sing N N 251 
NAG C2  H2   sing N N 252 
NAG C3  C4   sing N N 253 
NAG C3  O3   sing N N 254 
NAG C3  H3   sing N N 255 
NAG C4  C5   sing N N 256 
NAG C4  O4   sing N N 257 
NAG C4  H4   sing N N 258 
NAG C5  C6   sing N N 259 
NAG C5  O5   sing N N 260 
NAG C5  H5   sing N N 261 
NAG C6  O6   sing N N 262 
NAG C6  H61  sing N N 263 
NAG C6  H62  sing N N 264 
NAG C7  C8   sing N N 265 
NAG C7  N2   sing N N 266 
NAG C7  O7   doub N N 267 
NAG C8  H81  sing N N 268 
NAG C8  H82  sing N N 269 
NAG C8  H83  sing N N 270 
NAG N2  HN2  sing N N 271 
NAG O1  HO1  sing N N 272 
NAG O3  HO3  sing N N 273 
NAG O4  HO4  sing N N 274 
NAG O6  HO6  sing N N 275 
PHE N   CA   sing N N 276 
PHE N   H    sing N N 277 
PHE N   H2   sing N N 278 
PHE CA  C    sing N N 279 
PHE CA  CB   sing N N 280 
PHE CA  HA   sing N N 281 
PHE C   O    doub N N 282 
PHE C   OXT  sing N N 283 
PHE CB  CG   sing N N 284 
PHE CB  HB2  sing N N 285 
PHE CB  HB3  sing N N 286 
PHE CG  CD1  doub Y N 287 
PHE CG  CD2  sing Y N 288 
PHE CD1 CE1  sing Y N 289 
PHE CD1 HD1  sing N N 290 
PHE CD2 CE2  doub Y N 291 
PHE CD2 HD2  sing N N 292 
PHE CE1 CZ   doub Y N 293 
PHE CE1 HE1  sing N N 294 
PHE CE2 CZ   sing Y N 295 
PHE CE2 HE2  sing N N 296 
PHE CZ  HZ   sing N N 297 
PHE OXT HXT  sing N N 298 
PRO N   CA   sing N N 299 
PRO N   CD   sing N N 300 
PRO N   H    sing N N 301 
PRO CA  C    sing N N 302 
PRO CA  CB   sing N N 303 
PRO CA  HA   sing N N 304 
PRO C   O    doub N N 305 
PRO C   OXT  sing N N 306 
PRO CB  CG   sing N N 307 
PRO CB  HB2  sing N N 308 
PRO CB  HB3  sing N N 309 
PRO CG  CD   sing N N 310 
PRO CG  HG2  sing N N 311 
PRO CG  HG3  sing N N 312 
PRO CD  HD2  sing N N 313 
PRO CD  HD3  sing N N 314 
PRO OXT HXT  sing N N 315 
SER N   CA   sing N N 316 
SER N   H    sing N N 317 
SER N   H2   sing N N 318 
SER CA  C    sing N N 319 
SER CA  CB   sing N N 320 
SER CA  HA   sing N N 321 
SER C   O    doub N N 322 
SER C   OXT  sing N N 323 
SER CB  OG   sing N N 324 
SER CB  HB2  sing N N 325 
SER CB  HB3  sing N N 326 
SER OG  HG   sing N N 327 
SER OXT HXT  sing N N 328 
THR N   CA   sing N N 329 
THR N   H    sing N N 330 
THR N   H2   sing N N 331 
THR CA  C    sing N N 332 
THR CA  CB   sing N N 333 
THR CA  HA   sing N N 334 
THR C   O    doub N N 335 
THR C   OXT  sing N N 336 
THR CB  OG1  sing N N 337 
THR CB  CG2  sing N N 338 
THR CB  HB   sing N N 339 
THR OG1 HG1  sing N N 340 
THR CG2 HG21 sing N N 341 
THR CG2 HG22 sing N N 342 
THR CG2 HG23 sing N N 343 
THR OXT HXT  sing N N 344 
TRP N   CA   sing N N 345 
TRP N   H    sing N N 346 
TRP N   H2   sing N N 347 
TRP CA  C    sing N N 348 
TRP CA  CB   sing N N 349 
TRP CA  HA   sing N N 350 
TRP C   O    doub N N 351 
TRP C   OXT  sing N N 352 
TRP CB  CG   sing N N 353 
TRP CB  HB2  sing N N 354 
TRP CB  HB3  sing N N 355 
TRP CG  CD1  doub Y N 356 
TRP CG  CD2  sing Y N 357 
TRP CD1 NE1  sing Y N 358 
TRP CD1 HD1  sing N N 359 
TRP CD2 CE2  doub Y N 360 
TRP CD2 CE3  sing Y N 361 
TRP NE1 CE2  sing Y N 362 
TRP NE1 HE1  sing N N 363 
TRP CE2 CZ2  sing Y N 364 
TRP CE3 CZ3  doub Y N 365 
TRP CE3 HE3  sing N N 366 
TRP CZ2 CH2  doub Y N 367 
TRP CZ2 HZ2  sing N N 368 
TRP CZ3 CH2  sing Y N 369 
TRP CZ3 HZ3  sing N N 370 
TRP CH2 HH2  sing N N 371 
TRP OXT HXT  sing N N 372 
TYR N   CA   sing N N 373 
TYR N   H    sing N N 374 
TYR N   H2   sing N N 375 
TYR CA  C    sing N N 376 
TYR CA  CB   sing N N 377 
TYR CA  HA   sing N N 378 
TYR C   O    doub N N 379 
TYR C   OXT  sing N N 380 
TYR CB  CG   sing N N 381 
TYR CB  HB2  sing N N 382 
TYR CB  HB3  sing N N 383 
TYR CG  CD1  doub Y N 384 
TYR CG  CD2  sing Y N 385 
TYR CD1 CE1  sing Y N 386 
TYR CD1 HD1  sing N N 387 
TYR CD2 CE2  doub Y N 388 
TYR CD2 HD2  sing N N 389 
TYR CE1 CZ   doub Y N 390 
TYR CE1 HE1  sing N N 391 
TYR CE2 CZ   sing Y N 392 
TYR CE2 HE2  sing N N 393 
TYR CZ  OH   sing N N 394 
TYR OH  HH   sing N N 395 
TYR OXT HXT  sing N N 396 
VAL N   CA   sing N N 397 
VAL N   H    sing N N 398 
VAL N   H2   sing N N 399 
VAL CA  C    sing N N 400 
VAL CA  CB   sing N N 401 
VAL CA  HA   sing N N 402 
VAL C   O    doub N N 403 
VAL C   OXT  sing N N 404 
VAL CB  CG1  sing N N 405 
VAL CB  CG2  sing N N 406 
VAL CB  HB   sing N N 407 
VAL CG1 HG11 sing N N 408 
VAL CG1 HG12 sing N N 409 
VAL CG1 HG13 sing N N 410 
VAL CG2 HG21 sing N N 411 
VAL CG2 HG22 sing N N 412 
VAL CG2 HG23 sing N N 413 
VAL OXT HXT  sing N N 414 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5k6i 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 41 3 2' 
_space_group.name_Hall        'P 4bd 2ab 3' 
_space_group.IT_number        213 
_space_group.crystal_system   cubic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W3J 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005909 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005909 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005909 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 7.96527 ?       ? ? 9.05267  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 30  ? 163.01100 334.35800 33.84000  1.000 70.84055  ? 26  GLN F N   1 
ATOM   2    C CA  . GLN A 1 30  ? 161.98000 334.53100 34.86200  1.000 79.38887  ? 26  GLN F CA  1 
ATOM   3    C C   . GLN A 1 30  ? 161.42600 335.97300 34.85600  1.000 71.51246  ? 26  GLN F C   1 
ATOM   4    O O   . GLN A 1 30  ? 160.77800 336.41300 33.88200  1.000 57.60628  ? 26  GLN F O   1 
ATOM   5    C CB  . GLN A 1 30  ? 162.53400 334.16200 36.24600  1.000 75.61440  ? 26  GLN F CB  1 
ATOM   6    C CG  . GLN A 1 30  ? 162.17900 332.73800 36.66000  1.000 81.18794  ? 26  GLN F CG  1 
ATOM   7    C CD  . GLN A 1 30  ? 160.67700 332.51500 36.73600  1.000 82.49778  ? 26  GLN F CD  1 
ATOM   8    O OE1 . GLN A 1 30  ? 159.97300 333.17400 37.51200  1.000 77.40946  ? 26  GLN F OE1 1 
ATOM   9    N NE2 . GLN A 1 30  ? 160.17600 331.59300 35.91600  1.000 80.05406  ? 26  GLN F NE2 1 
ATOM   10   N N   . ASN A 1 31  ? 161.62600 336.67600 35.97000  1.000 63.82872  ? 27  ASN F N   1 
ATOM   11   C CA  . ASN A 1 31  ? 161.15900 338.04600 36.10800  1.000 57.46199  ? 27  ASN F CA  1 
ATOM   12   C C   . ASN A 1 31  ? 162.29900 338.95800 35.65400  1.000 49.92903  ? 27  ASN F C   1 
ATOM   13   O O   . ASN A 1 31  ? 163.41400 338.89200 36.18500  1.000 47.90401  ? 27  ASN F O   1 
ATOM   14   C CB  . ASN A 1 31  ? 160.72600 338.37600 37.53900  1.000 59.87572  ? 27  ASN F CB  1 
ATOM   15   C CG  . ASN A 1 31  ? 161.61600 337.72600 38.59300  1.000 73.77123  ? 27  ASN F CG  1 
ATOM   16   O OD1 . ASN A 1 31  ? 162.38900 336.80700 38.29100  1.000 77.50283  ? 27  ASN F OD1 1 
ATOM   17   N ND2 . ASN A 1 31  ? 161.59000 338.27700 39.81600  1.000 67.87487  ? 27  ASN F ND2 1 
ATOM   18   N N   . ILE A 1 32  ? 162.02800 339.77300 34.64600  1.000 45.57121  ? 28  ILE F N   1 
ATOM   19   C CA  . ILE A 1 32  ? 162.99300 340.73200 34.12800  1.000 39.79512  ? 28  ILE F CA  1 
ATOM   20   C C   . ILE A 1 32  ? 162.97500 341.95800 35.03000  1.000 37.20689  ? 28  ILE F C   1 
ATOM   21   O O   . ILE A 1 32  ? 161.90200 342.46700 35.36200  1.000 40.88652  ? 28  ILE F O   1 
ATOM   22   C CB  . ILE A 1 32  ? 162.62800 341.14800 32.69800  1.000 43.23455  ? 28  ILE F CB  1 
ATOM   23   C CG1 . ILE A 1 32  ? 162.58900 339.96200 31.74300  1.000 44.14978  ? 28  ILE F CG1 1 
ATOM   24   C CG2 . ILE A 1 32  ? 163.66800 342.12900 32.18600  1.000 33.90868  ? 28  ILE F CG2 1 
ATOM   25   C CD1 . ILE A 1 32  ? 163.83200 339.16100 31.71400  1.000 42.62886  ? 28  ILE F CD1 1 
ATOM   26   N N   . THR A 1 33  ? 164.12500 342.37700 35.53500  1.000 36.03735  ? 29  THR F N   1 
ATOM   27   C CA  . THR A 1 33  ? 164.10700 343.57500 36.36600  1.000 36.37858  ? 29  THR F CA  1 
ATOM   28   C C   . THR A 1 33  ? 165.16800 344.53900 35.85200  1.000 30.77249  ? 29  THR F C   1 
ATOM   29   O O   . THR A 1 33  ? 166.07400 344.16300 35.11000  1.000 34.11978  ? 29  THR F O   1 
ATOM   30   C CB  . THR A 1 33  ? 164.30000 343.26300 37.86000  1.000 33.73068  ? 29  THR F CB  1 
ATOM   31   O OG1 . THR A 1 33  ? 165.52700 342.55000 38.06500  1.000 42.16381  ? 29  THR F OG1 1 
ATOM   32   C CG2 . THR A 1 33  ? 163.14200 342.40600 38.33800  1.000 29.27129  ? 29  THR F CG2 1 
ATOM   33   N N   . GLU A 1 34  ? 165.05800 345.78900 36.27900  1.000 30.75026  ? 30  GLU F N   1 
ATOM   34   C CA  . GLU A 1 34  ? 165.95700 346.86100 35.88100  1.000 31.21233  ? 30  GLU F CA  1 
ATOM   35   C C   . GLU A 1 34  ? 166.31300 347.72900 37.05600  1.000 32.17192  ? 30  GLU F C   1 
ATOM   36   O O   . GLU A 1 34  ? 165.49500 347.95900 37.94200  1.000 38.89643  ? 30  GLU F O   1 
ATOM   37   C CB  . GLU A 1 34  ? 165.35100 347.77500 34.81800  1.000 31.90489  ? 30  GLU F CB  1 
ATOM   38   C CG  . GLU A 1 34  ? 165.50100 347.31000 33.41200  1.000 34.14258  ? 30  GLU F CG  1 
ATOM   39   C CD  . GLU A 1 34  ? 165.61700 348.47400 32.45900  1.000 33.30899  ? 30  GLU F CD  1 
ATOM   40   O OE1 . GLU A 1 34  ? 165.97300 349.57100 32.92300  1.000 34.98439  ? 30  GLU F OE1 1 
ATOM   41   O OE2 . GLU A 1 34  ? 165.35000 348.29400 31.24000  1.000 36.78399  ? 30  GLU F OE2 1 
ATOM   42   N N   . GLU A 1 35  ? 167.47800 348.34900 36.94400  1.000 32.10790  ? 31  GLU F N   1 
ATOM   43   C CA  . GLU A 1 35  ? 167.98600 349.26700 37.94200  1.000 29.66289  ? 31  GLU F CA  1 
ATOM   44   C C   . GLU A 1 35  ? 168.62400 350.43300 37.22000  1.000 28.44633  ? 31  GLU F C   1 
ATOM   45   O O   . GLU A 1 35  ? 169.49800 350.22600 36.36900  1.000 30.49806  ? 31  GLU F O   1 
ATOM   46   C CB  . GLU A 1 35  ? 169.01100 348.59900 38.85100  1.000 39.10896  ? 31  GLU F CB  1 
ATOM   47   C CG  . GLU A 1 35  ? 168.44000 347.61500 39.86800  1.000 42.69516  ? 31  GLU F CG  1 
ATOM   48   C CD  . GLU A 1 35  ? 169.55200 346.91600 40.63200  1.000 49.19074  ? 31  GLU F CD  1 
ATOM   49   O OE1 . GLU A 1 35  ? 170.68400 347.47500 40.69000  1.000 46.21681  ? 31  GLU F OE1 1 
ATOM   50   O OE2 . GLU A 1 35  ? 169.30500 345.79900 41.13800  1.000 56.73211  ? 31  GLU F OE2 1 
ATOM   51   N N   . PHE A 1 36  ? 168.06000 351.62100 37.40600  1.000 24.64726  ? 32  PHE F N   1 
ATOM   52   C CA  . PHE A 1 36  ? 168.65100 352.83400 36.86300  1.000 24.83617  ? 32  PHE F CA  1 
ATOM   53   C C   . PHE A 1 36  ? 169.49400 353.47400 37.95200  1.000 27.59385  ? 32  PHE F C   1 
ATOM   54   O O   . PHE A 1 36  ? 169.03000 353.59800 39.09500  1.000 30.60651  ? 32  PHE F O   1 
ATOM   55   C CB  . PHE A 1 36  ? 167.59500 353.82200 36.39400  1.000 22.41916  ? 32  PHE F CB  1 
ATOM   56   C CG  . PHE A 1 36  ? 168.16500 355.14500 36.02000  1.000 27.27874  ? 32  PHE F CG  1 
ATOM   57   C CD1 . PHE A 1 36  ? 168.82600 355.31500 34.79100  1.000 25.88486  ? 32  PHE F CD1 1 
ATOM   58   C CD2 . PHE A 1 36  ? 168.06100 356.22900 36.88400  1.000 23.31942  ? 32  PHE F CD2 1 
ATOM   59   C CE1 . PHE A 1 36  ? 169.35800 356.55900 34.42100  1.000 22.18753  ? 32  PHE F CE1 1 
ATOM   60   C CE2 . PHE A 1 36  ? 168.59800 357.46900 36.51700  1.000 22.89800  ? 32  PHE F CE2 1 
ATOM   61   C CZ  . PHE A 1 36  ? 169.24300 357.62800 35.28500  1.000 22.20438  ? 32  PHE F CZ  1 
ATOM   62   N N   . TYR A 1 37  ? 170.74400 353.83400 37.61800  1.000 25.10533  ? 33  TYR F N   1 
ATOM   63   C CA  . TYR A 1 37  ? 171.65900 354.43200 38.59000  1.000 26.68879  ? 33  TYR F CA  1 
ATOM   64   C C   . TYR A 1 37  ? 171.74300 355.90400 38.20700  1.000 28.37099  ? 33  TYR F C   1 
ATOM   65   O O   . TYR A 1 37  ? 172.46800 356.27800 37.27300  1.000 27.56005  ? 33  TYR F O   1 
ATOM   66   C CB  . TYR A 1 37  ? 173.03700 353.76900 38.55900  1.000 28.90660  ? 33  TYR F CB  1 
ATOM   67   C CG  . TYR A 1 37  ? 172.87000 352.28200 38.68600  1.000 30.09432  ? 33  TYR F CG  1 
ATOM   68   C CD1 . TYR A 1 37  ? 172.63300 351.65500 39.89400  1.000 27.83154  ? 33  TYR F CD1 1 
ATOM   69   C CD2 . TYR A 1 37  ? 173.01400 351.50100 37.56800  1.000 31.88616  ? 33  TYR F CD2 1 
ATOM   70   C CE1 . TYR A 1 37  ? 172.46300 350.28600 39.95200  1.000 34.07190  ? 33  TYR F CE1 1 
ATOM   71   C CE2 . TYR A 1 37  ? 172.88100 350.14200 37.61600  1.000 33.42337  ? 33  TYR F CE2 1 
ATOM   72   C CZ  . TYR A 1 37  ? 172.59500 349.52900 38.79000  1.000 36.09969  ? 33  TYR F CZ  1 
ATOM   73   O OH  . TYR A 1 37  ? 172.44600 348.15300 38.74600  1.000 34.79699  ? 33  TYR F OH  1 
ATOM   74   N N   . GLN A 1 38  ? 171.07100 356.75100 38.97700  1.000 27.79310  ? 34  GLN F N   1 
ATOM   75   C CA  . GLN A 1 38  ? 171.09700 358.17400 38.68600  1.000 22.06612  ? 34  GLN F CA  1 
ATOM   76   C C   . GLN A 1 38  ? 172.49600 358.75700 38.76000  1.000 22.99101  ? 34  GLN F C   1 
ATOM   77   O O   . GLN A 1 38  ? 172.76300 359.77300 38.12400  1.000 33.04236  ? 34  GLN F O   1 
ATOM   78   C CB  . GLN A 1 38  ? 170.17800 358.90100 39.65000  1.000 27.91385  ? 34  GLN F CB  1 
ATOM   79   C CG  . GLN A 1 38  ? 170.16900 360.38600 39.46800  1.000 34.82491  ? 34  GLN F CG  1 
ATOM   80   C CD  . GLN A 1 38  ? 169.32600 361.07600 40.50400  1.000 38.21315  ? 34  GLN F CD  1 
ATOM   81   O OE1 . GLN A 1 38  ? 168.27400 360.57700 40.87500  1.000 43.87088  ? 34  GLN F OE1 1 
ATOM   82   N NE2 . GLN A 1 38  ? 169.72500 362.27300 40.90000  1.000 47.90952  ? 34  GLN F NE2 1 
ATOM   83   N N   . SER A 1 39  ? 173.38600 358.16900 39.55900  1.000 28.90696  ? 35  SER F N   1 
ATOM   84   C CA  . SER A 1 39  ? 174.73500 358.72100 39.74400  1.000 27.38268  ? 35  SER F CA  1 
ATOM   85   C C   . SER A 1 39  ? 175.62700 358.56100 38.51100  1.000 28.19339  ? 35  SER F C   1 
ATOM   86   O O   . SER A 1 39  ? 176.59800 359.30900 38.36700  1.000 29.06145  ? 35  SER F O   1 
ATOM   87   C CB  . SER A 1 39  ? 175.42400 358.09000 40.95200  1.000 25.77888  ? 35  SER F CB  1 
ATOM   88   O OG  . SER A 1 39  ? 175.57400 356.69700 40.78300  1.000 31.83035  ? 35  SER F OG  1 
ATOM   89   N N   . THR A 1 40  ? 175.44200 357.49900 37.71900  1.000 28.20878  ? 36  THR F N   1 
ATOM   90   C CA  . THR A 1 40  ? 176.31200 357.24100 36.58100  1.000 26.67349  ? 36  THR F CA  1 
ATOM   91   C C   . THR A 1 40  ? 175.56400 357.26500 35.25900  1.000 29.98173  ? 36  THR F C   1 
ATOM   92   O O   . THR A 1 40  ? 176.16700 356.95300 34.21800  1.000 28.61290  ? 36  THR F O   1 
ATOM   93   C CB  . THR A 1 40  ? 177.04500 355.90400 36.71700  1.000 27.95824  ? 36  THR F CB  1 
ATOM   94   O OG1 . THR A 1 40  ? 176.10700 354.86100 36.91800  1.000 30.29261  ? 36  THR F OG1 1 
ATOM   95   C CG2 . THR A 1 40  ? 177.91600 355.93900 37.94300  1.000 29.30829  ? 36  THR F CG2 1 
ATOM   96   N N   . CYS A 1 41  ? 174.26000 357.57500 35.27100  1.000 28.29100  ? 37  CYS F N   1 
ATOM   97   C CA  . CYS A 1 41  ? 173.46200 357.64700 34.04500  1.000 23.67837  ? 37  CYS F CA  1 
ATOM   98   C C   . CYS A 1 41  ? 173.52700 356.34200 33.25900  1.000 21.98713  ? 37  CYS F C   1 
ATOM   99   O O   . CYS A 1 41  ? 173.86000 356.32800 32.07700  1.000 23.53682  ? 37  CYS F O   1 
ATOM   100  C CB  . CYS A 1 41  ? 173.92800 358.81700 33.17200  1.000 24.81741  ? 37  CYS F CB  1 
ATOM   101  S SG  . CYS A 1 41  ? 172.82200 359.30200 31.74700  1.000 32.33933  ? 37  CYS F SG  1 
ATOM   102  N N   . SER A 1 42  ? 173.28800 355.22900 33.95300  1.000 20.66632  ? 38  SER F N   1 
ATOM   103  C CA  . SER A 1 42  ? 173.35200 353.89900 33.36800  1.000 19.45509  ? 38  SER F CA  1 
ATOM   104  C C   . SER A 1 42  ? 172.25700 353.05300 34.00700  1.000 22.49093  ? 38  SER F C   1 
ATOM   105  O O   . SER A 1 42  ? 171.71600 353.40200 35.05900  1.000 24.02699  ? 38  SER F O   1 
ATOM   106  C CB  . SER A 1 42  ? 174.71300 353.24100 33.53400  1.000 19.02048  ? 38  SER F CB  1 
ATOM   107  O OG  . SER A 1 42  ? 175.14700 353.28400 34.88000  1.000 24.08981  ? 38  SER F OG  1 
ATOM   108  N N   . ALA A 1 43  ? 171.83100 352.01800 33.28400  1.000 21.61031  ? 39  ALA F N   1 
ATOM   109  C CA  . ALA A 1 43  ? 170.80300 351.08300 33.72400  1.000 22.08724  ? 39  ALA F CA  1 
ATOM   110  C C   . ALA A 1 43  ? 171.26800 349.66000 33.44800  1.000 23.53811  ? 39  ALA F C   1 
ATOM   111  O O   . ALA A 1 43  ? 172.01100 349.42300 32.49600  1.000 22.00290  ? 39  ALA F O   1 
ATOM   112  C CB  . ALA A 1 43  ? 169.45700 351.35300 33.07800  1.000 19.97865  ? 39  ALA F CB  1 
ATOM   113  N N   . VAL A 1 44  ? 170.84300 348.71500 34.28500  1.000 24.36223  ? 40  VAL F N   1 
ATOM   114  C CA  . VAL A 1 44  ? 171.18500 347.29700 34.12800  1.000 25.27435  ? 40  VAL F CA  1 
ATOM   115  C C   . VAL A 1 44  ? 169.90800 346.48000 34.06300  1.000 23.28264  ? 40  VAL F C   1 
ATOM   116  O O   . VAL A 1 44  ? 169.03700 346.61000 34.93100  1.000 28.92565  ? 40  VAL F O   1 
ATOM   117  C CB  . VAL A 1 44  ? 172.07100 346.76200 35.26700  1.000 26.56846  ? 40  VAL F CB  1 
ATOM   118  C CG1 . VAL A 1 44  ? 172.35600 345.30600 35.02600  1.000 24.68369  ? 40  VAL F CG1 1 
ATOM   119  C CG2 . VAL A 1 44  ? 173.39800 347.46000 35.26400  1.000 25.70485  ? 40  VAL F CG2 1 
ATOM   120  N N   . SER A 1 45  ? 169.73900 345.73500 32.97300  1.000 21.55091  ? 41  SER F N   1 
ATOM   121  C CA  . SER A 1 45  ? 168.57100 344.86700 32.81400  1.000 30.09629  ? 41  SER F CA  1 
ATOM   122  C C   . SER A 1 45  ? 168.94500 343.43600 33.23200  1.000 29.97909  ? 41  SER F C   1 
ATOM   123  O O   . SER A 1 45  ? 169.72300 342.76600 32.54400  1.000 31.22591  ? 41  SER F O   1 
ATOM   124  C CB  . SER A 1 45  ? 168.08400 344.92400 31.36700  1.000 31.11330  ? 41  SER F CB  1 
ATOM   125  O OG  . SER A 1 45  ? 167.76600 346.25300 30.98100  1.000 32.17813  ? 41  SER F OG  1 
ATOM   126  N N   . LYS A 1 46  ? 168.39900 342.96800 34.35100  1.000 30.20949  ? 42  LYS F N   1 
ATOM   127  C CA  . LYS A 1 46  ? 168.69300 341.64900 34.90300  1.000 29.67865  ? 42  LYS F CA  1 
ATOM   128  C C   . LYS A 1 46  ? 167.56000 340.65800 34.66300  1.000 31.15305  ? 42  LYS F C   1 
ATOM   129  O O   . LYS A 1 46  ? 166.43500 341.01600 34.29500  1.000 34.32469  ? 42  LYS F O   1 
ATOM   130  C CB  . LYS A 1 46  ? 169.01100 341.71300 36.40100  1.000 37.55999  ? 42  LYS F CB  1 
ATOM   131  C CG  . LYS A 1 46  ? 170.26300 342.49000 36.71000  1.000 40.51576  ? 42  LYS F CG  1 
ATOM   132  C CD  . LYS A 1 46  ? 170.48300 342.62300 38.20700  1.000 51.38594  ? 42  LYS F CD  1 
ATOM   133  C CE  . LYS A 1 46  ? 169.19200 342.84700 38.95900  1.000 55.12501  ? 42  LYS F CE  1 
ATOM   134  N NZ  . LYS A 1 46  ? 169.54300 343.12700 40.39000  1.000 61.67271  ? 42  LYS F NZ  1 
ATOM   135  N N   . GLY A 1 47  ? 167.86100 339.39600 34.94900  1.000 31.40895  ? 43  GLY F N   1 
ATOM   136  C CA  . GLY A 1 47  ? 166.87900 338.32800 34.92700  1.000 29.64274  ? 43  GLY F CA  1 
ATOM   137  C C   . GLY A 1 47  ? 166.89700 337.46400 33.69200  1.000 34.82168  ? 43  GLY F C   1 
ATOM   138  O O   . GLY A 1 47  ? 166.03600 336.59300 33.56200  1.000 39.65917  ? 43  GLY F O   1 
ATOM   139  N N   . TYR A 1 48  ? 167.81500 337.70500 32.75900  1.000 34.96564  ? 44  TYR F N   1 
ATOM   140  C CA  . TYR A 1 48  ? 167.85300 336.93000 31.53400  1.000 29.69114  ? 44  TYR F CA  1 
ATOM   141  C C   . TYR A 1 48  ? 168.63600 335.64600 31.76200  1.000 30.86770  ? 44  TYR F C   1 
ATOM   142  O O   . TYR A 1 48  ? 169.57000 335.61100 32.57100  1.000 33.49736  ? 44  TYR F O   1 
ATOM   143  C CB  . TYR A 1 48  ? 168.51200 337.71900 30.40800  1.000 36.63582  ? 44  TYR F CB  1 
ATOM   144  C CG  . TYR A 1 48  ? 167.73400 338.94400 29.93400  1.000 39.10726  ? 44  TYR F CG  1 
ATOM   145  C CD1 . TYR A 1 48  ? 167.87600 340.16900 30.59500  1.000 32.01735  ? 44  TYR F CD1 1 
ATOM   146  C CD2 . TYR A 1 48  ? 166.81900 338.86300 28.88900  1.000 30.29750  ? 44  TYR F CD2 1 
ATOM   147  C CE1 . TYR A 1 48  ? 167.19800 341.26900 30.19300  1.000 30.96439  ? 44  TYR F CE1 1 
ATOM   148  C CE2 . TYR A 1 48  ? 166.12900 339.95000 28.48900  1.000 31.32568  ? 44  TYR F CE2 1 
ATOM   149  C CZ  . TYR A 1 48  ? 166.31100 341.16900 29.13600  1.000 39.78644  ? 44  TYR F CZ  1 
ATOM   150  O OH  . TYR A 1 48  ? 165.60000 342.29900 28.71400  1.000 41.36850  ? 44  TYR F OH  1 
ATOM   151  N N   . LEU A 1 49  ? 168.19300 334.56700 31.12800  1.000 33.04301  ? 45  LEU F N   1 
ATOM   152  C CA  . LEU A 1 49  ? 168.87400 333.28300 31.16900  1.000 24.78338  ? 45  LEU F CA  1 
ATOM   153  C C   . LEU A 1 49  ? 169.64100 333.08300 29.87000  1.000 26.84806  ? 45  LEU F C   1 
ATOM   154  O O   . LEU A 1 49  ? 169.02400 332.99300 28.80900  1.000 30.21991  ? 45  LEU F O   1 
ATOM   155  C CB  . LEU A 1 49  ? 167.84900 332.18400 31.34200  1.000 33.40044  ? 45  LEU F CB  1 
ATOM   156  C CG  . LEU A 1 49  ? 167.14400 332.36900 32.67200  1.000 35.43280  ? 45  LEU F CG  1 
ATOM   157  C CD1 . LEU A 1 49  ? 166.09100 331.29500 32.77900  1.000 35.82540  ? 45  LEU F CD1 1 
ATOM   158  C CD2 . LEU A 1 49  ? 168.16800 332.32200 33.81200  1.000 31.07097  ? 45  LEU F CD2 1 
ATOM   159  N N   . GLY A 1 50  ? 170.96000 332.92800 29.94500  1.000 28.14401  ? 46  GLY F N   1 
ATOM   160  C CA  . GLY A 1 50  ? 171.79500 332.85600 28.76000  1.000 23.90235  ? 46  GLY F CA  1 
ATOM   161  C C   . GLY A 1 50  ? 172.12100 331.43600 28.31500  1.000 28.32765  ? 46  GLY F C   1 
ATOM   162  O O   . GLY A 1 50  ? 172.25100 330.51900 29.12100  1.000 31.11218  ? 46  GLY F O   1 
ATOM   163  N N   . ALA A 1 51  ? 172.33300 331.28800 27.01200  1.000 30.32620  ? 47  ALA F N   1 
ATOM   164  C CA  . ALA A 1 51  ? 172.75400 330.05100 26.36600  1.000 26.41524  ? 47  ALA F CA  1 
ATOM   165  C C   . ALA A 1 51  ? 173.91500 330.44500 25.46000  1.000 32.34915  ? 47  ALA F C   1 
ATOM   166  O O   . ALA A 1 51  ? 173.72300 331.18100 24.49100  1.000 32.29018  ? 47  ALA F O   1 
ATOM   167  C CB  . ALA A 1 51  ? 171.61600 329.40500 25.60100  1.000 28.10984  ? 47  ALA F CB  1 
ATOM   168  N N   . LEU A 1 52  ? 175.12700 330.17500 25.92200  1.000 37.62328  ? 48  LEU F N   1 
ATOM   169  C CA  . LEU A 1 52  ? 176.37400 330.55500 25.26300  1.000 34.85946  ? 48  LEU F CA  1 
ATOM   170  C C   . LEU A 1 52  ? 176.91200 329.41900 24.40800  1.000 33.97343  ? 48  LEU F C   1 
ATOM   171  O O   . LEU A 1 52  ? 176.99900 328.28600 24.87600  1.000 36.48478  ? 48  LEU F O   1 
ATOM   172  C CB  . LEU A 1 52  ? 177.42600 330.94000 26.30000  1.000 34.35516  ? 48  LEU F CB  1 
ATOM   173  C CG  . LEU A 1 52  ? 176.96200 331.96200 27.33000  1.000 30.25799  ? 48  LEU F CG  1 
ATOM   174  C CD1 . LEU A 1 52  ? 178.12400 332.39700 28.20800  1.000 26.46115  ? 48  LEU F CD1 1 
ATOM   175  C CD2 . LEU A 1 52  ? 176.27000 333.13100 26.64800  1.000 28.10646  ? 48  LEU F CD2 1 
ATOM   176  N N   . ARG A 1 53  ? 177.29700 329.71400 23.17600  1.000 35.85448  ? 49  ARG F N   1 
ATOM   177  C CA  . ARG A 1 53  ? 177.87300 328.68100 22.33100  1.000 39.59675  ? 49  ARG F CA  1 
ATOM   178  C C   . ARG A 1 53  ? 179.32600 328.42300 22.72900  1.000 44.64820  ? 49  ARG F C   1 
ATOM   179  O O   . ARG A 1 53  ? 180.16900 329.33000 22.67100  1.000 43.49185  ? 49  ARG F O   1 
ATOM   180  C CB  . ARG A 1 53  ? 177.84800 329.12600 20.86600  1.000 40.69496  ? 49  ARG F CB  1 
ATOM   181  C CG  . ARG A 1 53  ? 177.85300 327.98600 19.85700  1.000 41.54587  ? 49  ARG F CG  1 
ATOM   182  C CD  . ARG A 1 53  ? 178.30700 328.40900 18.43500  1.000 45.19984  ? 49  ARG F CD  1 
ATOM   183  N NE  . ARG A 1 53  ? 179.61400 329.05900 18.29100  1.000 44.77460  ? 49  ARG F NE  1 
ATOM   184  C CZ  . ARG A 1 53  ? 180.76100 328.63900 18.81900  1.000 48.03183  ? 49  ARG F CZ  1 
ATOM   185  N NH1 . ARG A 1 53  ? 180.80400 327.64900 19.70700  1.000 45.09284  ? 49  ARG F NH1 1 
ATOM   186  N NH2 . ARG A 1 53  ? 181.89500 329.23800 18.45700  1.000 46.56206  ? 49  ARG F NH2 1 
ATOM   187  N N   . THR A 1 54  ? 179.62400 327.15100 23.04200  1.000 45.14963  ? 50  THR F N   1 
ATOM   188  C CA  . THR A 1 54  ? 180.94100 326.67200 23.44300  1.000 39.60346  ? 50  THR F CA  1 
ATOM   189  C C   . THR A 1 54  ? 181.44800 325.52700 22.57700  1.000 49.27462  ? 50  THR F C   1 
ATOM   190  O O   . THR A 1 54  ? 182.63700 325.21000 22.65000  1.000 54.92489  ? 50  THR F O   1 
ATOM   191  C CB  . THR A 1 54  ? 180.92700 326.16200 24.89200  1.000 36.90665  ? 50  THR F CB  1 
ATOM   192  O OG1 . THR A 1 54  ? 180.02400 325.05000 24.98100  1.000 43.35229  ? 50  THR F OG1 1 
ATOM   193  C CG2 . THR A 1 54  ? 180.51000 327.25300 25.90000  1.000 37.90670  ? 50  THR F CG2 1 
ATOM   194  N N   . GLY A 1 55  ? 180.57700 324.87200 21.79500  1.000 50.54100  ? 51  GLY F N   1 
ATOM   195  C CA  . GLY A 1 55  ? 180.97500 323.77600 20.93500  1.000 51.14240  ? 51  GLY F CA  1 
ATOM   196  C C   . GLY A 1 55  ? 180.20000 323.79500 19.62800  1.000 50.96965  ? 51  GLY F C   1 
ATOM   197  O O   . GLY A 1 55  ? 179.29800 324.60800 19.43100  1.000 52.01233  ? 51  GLY F O   1 
ATOM   198  N N   . TRP A 1 56  ? 180.57900 322.88100 18.73700  1.000 54.25493  ? 52  TRP F N   1 
ATOM   199  C CA  . TRP A 1 56  ? 179.96900 322.69700 17.42300  1.000 51.26190  ? 52  TRP F CA  1 
ATOM   200  C C   . TRP A 1 56  ? 179.55400 321.23700 17.24500  1.000 52.49062  ? 52  TRP F C   1 
ATOM   201  O O   . TRP A 1 56  ? 180.24900 320.32400 17.70700  1.000 52.91501  ? 52  TRP F O   1 
ATOM   202  C CB  . TRP A 1 56  ? 180.90700 323.10600 16.32000  1.000 47.35326  ? 52  TRP F CB  1 
ATOM   203  C CG  . TRP A 1 56  ? 181.22800 324.56400 16.27700  1.000 50.36141  ? 52  TRP F CG  1 
ATOM   204  C CD1 . TRP A 1 56  ? 182.41000 325.14100 16.59500  1.000 49.96087  ? 52  TRP F CD1 1 
ATOM   205  C CD2 . TRP A 1 56  ? 180.38100 325.62200 15.80000  1.000 54.74982  ? 52  TRP F CD2 1 
ATOM   206  N NE1 . TRP A 1 56  ? 182.35300 326.49600 16.38100  1.000 55.11627  ? 52  TRP F NE1 1 
ATOM   207  C CE2 . TRP A 1 56  ? 181.12000 326.81600 15.88300  1.000 54.05215  ? 52  TRP F CE2 1 
ATOM   208  C CE3 . TRP A 1 56  ? 179.06900 325.67400 15.31400  1.000 47.44291  ? 52  TRP F CE3 1 
ATOM   209  C CZ2 . TRP A 1 56  ? 180.59500 328.04700 15.49900  1.000 50.51114  ? 52  TRP F CZ2 1 
ATOM   210  C CZ3 . TRP A 1 56  ? 178.55000 326.89700 14.94000  1.000 44.93115  ? 52  TRP F CZ3 1 
ATOM   211  C CH2 . TRP A 1 56  ? 179.31000 328.06600 15.03300  1.000 46.39677  ? 52  TRP F CH2 1 
ATOM   212  N N   . TYR A 1 57  ? 178.41400 321.00200 16.59900  1.000 52.59146  ? 53  TYR F N   1 
ATOM   213  C CA  . TYR A 1 57  ? 178.01900 319.64200 16.24500  1.000 55.53588  ? 53  TYR F CA  1 
ATOM   214  C C   . TYR A 1 57  ? 177.91400 319.59800 14.72200  1.000 53.16601  ? 53  TYR F C   1 
ATOM   215  O O   . TYR A 1 57  ? 177.07700 320.29700 14.14600  1.000 55.19089  ? 53  TYR F O   1 
ATOM   216  C CB  . TYR A 1 57  ? 176.71600 319.22300 16.94500  1.000 56.71008  ? 53  TYR F CB  1 
ATOM   217  C CG  . TYR A 1 57  ? 176.24600 317.83400 16.51700  1.000 71.42651  ? 53  TYR F CG  1 
ATOM   218  C CD1 . TYR A 1 57  ? 176.80200 316.69000 17.10600  1.000 75.10295  ? 53  TYR F CD1 1 
ATOM   219  C CD2 . TYR A 1 57  ? 175.26100 317.65200 15.54600  1.000 71.89240  ? 53  TYR F CD2 1 
ATOM   220  C CE1 . TYR A 1 57  ? 176.41200 315.40700 16.73500  1.000 73.25989  ? 53  TYR F CE1 1 
ATOM   221  C CE2 . TYR A 1 57  ? 174.86300 316.36300 15.16500  1.000 74.51629  ? 53  TYR F CE2 1 
ATOM   222  C CZ  . TYR A 1 57  ? 175.44400 315.24600 15.76600  1.000 79.34426  ? 53  TYR F CZ  1 
ATOM   223  O OH  . TYR A 1 57  ? 175.06400 313.96400 15.40800  1.000 86.78280  ? 53  TYR F OH  1 
ATOM   224  N N   . THR A 1 58  ? 178.82400 318.87700 14.05300  1.000 55.66395  ? 54  THR F N   1 
ATOM   225  C CA  . THR A 1 58  ? 178.80500 318.83400 12.59100  1.000 58.56033  ? 54  THR F CA  1 
ATOM   226  C C   . THR A 1 58  ? 177.97600 317.65700 12.07600  1.000 62.11345  ? 54  THR F C   1 
ATOM   227  O O   . THR A 1 58  ? 177.92900 316.58800 12.69600  1.000 63.01072  ? 54  THR F O   1 
ATOM   228  C CB  . THR A 1 58  ? 180.21300 318.71600 12.02900  1.000 52.47192  ? 54  THR F CB  1 
ATOM   229  O OG1 . THR A 1 58  ? 180.77800 317.49900 12.50800  1.000 66.98363  ? 54  THR F OG1 1 
ATOM   230  C CG2 . THR A 1 58  ? 181.07800 319.87200 12.49200  1.000 52.67946  ? 54  THR F CG2 1 
ATOM   231  N N   . SER A 1 59  ? 177.40300 317.83500 10.87600  1.000 63.39816  ? 55  SER F N   1 
ATOM   232  C CA  . SER A 1 59  ? 176.58200 316.82600 10.20800  1.000 60.76339  ? 55  SER F CA  1 
ATOM   233  C C   . SER A 1 59  ? 176.78500 316.93100 8.71500   1.000 54.56450  ? 55  SER F C   1 
ATOM   234  O O   . SER A 1 59  ? 176.95800 318.03200 8.19400   1.000 57.42201  ? 55  SER F O   1 
ATOM   235  C CB  . SER A 1 59  ? 175.08600 317.00300 10.47600  1.000 61.60555  ? 55  SER F CB  1 
ATOM   236  O OG  . SER A 1 59  ? 174.82100 317.21000 11.84800  1.000 70.08224  ? 55  SER F OG  1 
ATOM   237  N N   . VAL A 1 60  ? 176.81600 315.78200 8.03800   1.000 66.81896  ? 56  VAL F N   1 
ATOM   238  C CA  . VAL A 1 60  ? 177.05200 315.74100 6.60100   1.000 64.51554  ? 56  VAL F CA  1 
ATOM   239  C C   . VAL A 1 60  ? 175.70800 315.69700 5.89800   1.000 59.59884  ? 56  VAL F C   1 
ATOM   240  O O   . VAL A 1 60  ? 174.85100 314.87400 6.24200   1.000 65.38702  ? 56  VAL F O   1 
ATOM   241  C CB  . VAL A 1 60  ? 177.91100 314.53100 6.21400   1.000 63.41659  ? 56  VAL F CB  1 
ATOM   242  C CG1 . VAL A 1 60  ? 178.57800 314.79200 4.87400   1.000 63.12291  ? 56  VAL F CG1 1 
ATOM   243  C CG2 . VAL A 1 60  ? 178.89900 314.21400 7.31200   1.000 65.28429  ? 56  VAL F CG2 1 
ATOM   244  N N   . ILE A 1 61  ? 175.50900 316.58600 4.93400   1.000 55.49072  ? 57  ILE F N   1 
ATOM   245  C CA  . ILE A 1 61  ? 174.29100 316.61900 4.13700   1.000 59.94887  ? 57  ILE F CA  1 
ATOM   246  C C   . ILE A 1 61  ? 174.68100 316.28800 2.70800   1.000 59.60395  ? 57  ILE F C   1 
ATOM   247  O O   . ILE A 1 61  ? 175.46900 317.01800 2.09300   1.000 56.45109  ? 57  ILE F O   1 
ATOM   248  C CB  . ILE A 1 61  ? 173.58400 317.97500 4.22900   1.000 57.04626  ? 57  ILE F CB  1 
ATOM   249  C CG1 . ILE A 1 61  ? 173.47500 318.44000 5.67600   1.000 48.24419  ? 57  ILE F CG1 1 
ATOM   250  C CG2 . ILE A 1 61  ? 172.19200 317.84000 3.67900   1.000 60.82201  ? 57  ILE F CG2 1 
ATOM   251  C CD1 . ILE A 1 61  ? 172.69000 317.51700 6.57200   1.000 47.37139  ? 57  ILE F CD1 1 
ATOM   252  N N   . THR A 1 62  ? 174.15500 315.18100 2.18500   1.000 66.19230  ? 58  THR F N   1 
ATOM   253  C CA  . THR A 1 62  ? 174.50800 314.71000 0.85000   1.000 69.42075  ? 58  THR F CA  1 
ATOM   254  C C   . THR A 1 62  ? 173.37400 314.85800 -0.15200  1.000 61.71355  ? 58  THR F C   1 
ATOM   255  O O   . THR A 1 62  ? 172.19400 314.78200 0.20200   1.000 62.47697  ? 58  THR F O   1 
ATOM   256  C CB  . THR A 1 62  ? 174.91300 313.23800 0.88800   1.000 64.23251  ? 58  THR F CB  1 
ATOM   257  O OG1 . THR A 1 62  ? 173.74500 312.45200 1.18300   1.000 66.53004  ? 58  THR F OG1 1 
ATOM   258  C CG2 . THR A 1 62  ? 175.99200 312.99400 1.92900   1.000 66.37788  ? 58  THR F CG2 1 
ATOM   259  N N   . ILE A 1 63  ? 173.74700 315.09000 -1.41000  1.000 65.19577  ? 59  ILE F N   1 
ATOM   260  C CA  . ILE A 1 63  ? 172.79700 315.08200 -2.51800  1.000 67.42381  ? 59  ILE F CA  1 
ATOM   261  C C   . ILE A 1 63  ? 173.39300 314.19300 -3.61200  1.000 64.61893  ? 59  ILE F C   1 
ATOM   262  O O   . ILE A 1 63  ? 174.41400 314.55300 -4.21900  1.000 59.73884  ? 59  ILE F O   1 
ATOM   263  C CB  . ILE A 1 63  ? 172.53500 316.50600 -3.03800  1.000 62.14445  ? 59  ILE F CB  1 
ATOM   264  C CG1 . ILE A 1 63  ? 171.75400 317.31300 -1.99500  1.000 56.90183  ? 59  ILE F CG1 1 
ATOM   265  C CG2 . ILE A 1 63  ? 171.81000 316.48200 -4.37300  1.000 58.72596  ? 59  ILE F CG2 1 
ATOM   266  C CD1 . ILE A 1 63  ? 171.39300 318.72500 -2.44800  1.000 48.99516  ? 59  ILE F CD1 1 
ATOM   267  N N   . GLU A 1 64  ? 172.75100 313.04700 -3.87700  1.000 70.86572  ? 60  GLU F N   1 
ATOM   268  C CA  . GLU A 1 64  ? 173.22000 312.09400 -4.88800  1.000 69.90925  ? 60  GLU F CA  1 
ATOM   269  C C   . GLU A 1 64  ? 172.91800 312.63000 -6.28600  1.000 64.61277  ? 60  GLU F C   1 
ATOM   270  O O   . GLU A 1 64  ? 171.75200 312.86100 -6.61900  1.000 66.23764  ? 60  GLU F O   1 
ATOM   271  C CB  . GLU A 1 64  ? 172.63700 310.69400 -4.68200  1.000 73.32982  ? 60  GLU F CB  1 
ATOM   272  C CG  . GLU A 1 64  ? 173.60800 309.71900 -3.95100  1.000 76.92259  ? 60  GLU F CG  1 
ATOM   273  C CD  . GLU A 1 64  ? 172.95400 308.40600 -3.48300  1.000 88.90154  ? 60  GLU F CD  1 
ATOM   274  O OE1 . GLU A 1 64  ? 171.75400 308.19400 -3.76600  1.000 87.67114  ? 60  GLU F OE1 1 
ATOM   275  O OE2 . GLU A 1 64  ? 173.64500 307.57700 -2.83700  1.000 88.41699  ? 60  GLU F OE2 1 
ATOM   276  N N   . LEU A 1 65  ? 173.94800 312.92400 -7.06600  1.000 64.42794  ? 61  LEU F N   1 
ATOM   277  C CA  . LEU A 1 65  ? 173.77500 313.48100 -8.40100  1.000 66.89922  ? 61  LEU F CA  1 
ATOM   278  C C   . LEU A 1 65  ? 174.00800 312.41000 -9.46700  1.000 72.79342  ? 61  LEU F C   1 
ATOM   279  O O   . LEU A 1 65  ? 174.46000 311.30300 -9.18100  1.000 80.29668  ? 61  LEU F O   1 
ATOM   280  C CB  . LEU A 1 65  ? 174.70500 314.66900 -8.62200  1.000 65.70775  ? 61  LEU F CB  1 
ATOM   281  C CG  . LEU A 1 65  ? 174.42800 315.89300 -7.76400  1.000 59.92005  ? 61  LEU F CG  1 
ATOM   282  C CD1 . LEU A 1 65  ? 175.34600 316.99600 -8.21600  1.000 63.13197  ? 61  LEU F CD1 1 
ATOM   283  C CD2 . LEU A 1 65  ? 172.98000 316.31700 -7.88300  1.000 62.63914  ? 61  LEU F CD2 1 
ATOM   284  N N   . SER A 1 66  ? 173.64400 312.73700 -10.70600 1.000 73.71401  ? 62  SER F N   1 
ATOM   285  C CA  . SER A 1 66  ? 173.77000 311.82600 -11.84200 1.000 76.10973  ? 62  SER F CA  1 
ATOM   286  C C   . SER A 1 66  ? 174.84100 312.29700 -12.81900 1.000 79.40920  ? 62  SER F C   1 
ATOM   287  O O   . SER A 1 66  ? 174.71800 313.37800 -13.40500 1.000 75.81337  ? 62  SER F O   1 
ATOM   288  C CB  . SER A 1 66  ? 172.43400 311.72000 -12.57400 1.000 71.70568  ? 62  SER F CB  1 
ATOM   289  O OG  . SER A 1 66  ? 172.51400 310.78500 -13.62200 1.000 77.42613  ? 62  SER F OG  1 
ATOM   290  N N   . ASN A 1 67  ? 175.87300 311.46800 -13.01900 1.000 85.46871  ? 63  ASN F N   1 
ATOM   291  C CA  . ASN A 1 67  ? 176.94000 311.79100 -13.97000 1.000 90.64474  ? 63  ASN F CA  1 
ATOM   292  C C   . ASN A 1 67  ? 176.39900 311.42100 -15.34200 1.000 89.74545  ? 63  ASN F C   1 
ATOM   293  O O   . ASN A 1 67  ? 176.51800 310.28400 -15.80800 1.000 89.99847  ? 63  ASN F O   1 
ATOM   294  C CB  . ASN A 1 67  ? 178.24600 311.07500 -13.63700 1.000 85.56029  ? 63  ASN F CB  1 
ATOM   295  C CG  . ASN A 1 67  ? 179.43600 312.04900 -13.49300 1.000 87.98421  ? 63  ASN F CG  1 
ATOM   296  O OD1 . ASN A 1 67  ? 179.48400 313.11500 -14.12800 1.000 83.07001  ? 63  ASN F OD1 1 
ATOM   297  N ND2 . ASN A 1 67  ? 180.40000 311.67400 -12.65900 1.000 89.42421  ? 63  ASN F ND2 1 
ATOM   298  N N   . ILE A 1 68  ? 175.79100 312.40900 -15.98900 1.000 85.52772  ? 64  ILE F N   1 
ATOM   299  C CA  . ILE A 1 68  ? 175.20100 312.24800 -17.31300 1.000 92.24435  ? 64  ILE F CA  1 
ATOM   300  C C   . ILE A 1 68  ? 175.76100 313.38200 -18.15900 1.000 99.20363  ? 64  ILE F C   1 
ATOM   301  O O   . ILE A 1 68  ? 175.17200 314.46500 -18.24300 1.000 101.07845 ? 64  ILE F O   1 
ATOM   302  C CB  . ILE A 1 68  ? 173.67000 312.29800 -17.29900 1.000 91.88092  ? 64  ILE F CB  1 
ATOM   303  C CG1 . ILE A 1 68  ? 173.20200 313.62300 -16.68700 1.000 85.06594  ? 64  ILE F CG1 1 
ATOM   304  C CG2 . ILE A 1 68  ? 173.08300 311.09000 -16.56900 1.000 90.58986  ? 64  ILE F CG2 1 
ATOM   305  C CD1 . ILE A 1 68  ? 171.81500 314.03500 -17.11300 1.000 83.66957  ? 64  ILE F CD1 1 
ATOM   306  N N   . LYS A 1 69  ? 176.92700 313.16200 -18.75300 1.000 103.30681 ? 65  LYS F N   1 
ATOM   307  C CA  . LYS A 1 69  ? 177.41900 314.16000 -19.68000 1.000 107.04909 ? 65  LYS F CA  1 
ATOM   308  C C   . LYS A 1 69  ? 176.30600 314.40300 -20.70200 1.000 108.08459 ? 65  LYS F C   1 
ATOM   309  O O   . LYS A 1 69  ? 175.38700 313.58700 -20.85300 1.000 105.25608 ? 65  LYS F O   1 
ATOM   310  C CB  . LYS A 1 69  ? 178.73600 313.69600 -20.31200 1.000 110.32324 ? 65  LYS F CB  1 
ATOM   311  C CG  . LYS A 1 69  ? 179.87400 313.46600 -19.28600 1.000 103.99868 ? 65  LYS F CG  1 
ATOM   312  C CD  . LYS A 1 69  ? 180.04400 314.65400 -18.32300 1.000 96.42062  ? 65  LYS F CD  1 
ATOM   313  C CE  . LYS A 1 69  ? 180.40700 314.20100 -16.90700 1.000 88.86703  ? 65  LYS F CE  1 
ATOM   314  N NZ  . LYS A 1 69  ? 181.59600 313.30300 -16.86600 1.000 86.79068  ? 65  LYS F NZ  1 
ATOM   315  N N   . GLU A 1 70  ? 176.39800 315.50300 -21.44500 1.000 113.81869 ? 66  GLU F N   1 
ATOM   316  C CA  . GLU A 1 70  ? 175.28200 315.83600 -22.32200 1.000 115.23387 ? 66  GLU F CA  1 
ATOM   317  C C   . GLU A 1 70  ? 175.09600 314.76000 -23.38200 1.000 109.97853 ? 66  GLU F C   1 
ATOM   318  O O   . GLU A 1 70  ? 176.05800 314.25800 -23.97500 1.000 105.86870 ? 66  GLU F O   1 
ATOM   319  C CB  . GLU A 1 70  ? 175.46000 317.21900 -22.97900 1.000 119.43102 ? 66  GLU F CB  1 
ATOM   320  C CG  . GLU A 1 70  ? 176.70700 317.44900 -23.84200 1.000 119.55377 ? 66  GLU F CG  1 
ATOM   321  C CD  . GLU A 1 70  ? 176.66700 318.79500 -24.57800 1.000 118.04176 ? 66  GLU F CD  1 
ATOM   322  O OE1 . GLU A 1 70  ? 175.63500 319.49400 -24.49700 1.000 115.00542 ? 66  GLU F OE1 1 
ATOM   323  O OE2 . GLU A 1 70  ? 177.66900 319.16400 -25.22800 1.000 118.80530 ? 66  GLU F OE2 1 
ATOM   324  N N   . ASN A 1 71  ? 173.83400 314.42000 -23.62500 1.000 106.48438 ? 67  ASN F N   1 
ATOM   325  C CA  . ASN A 1 71  ? 173.49000 313.44100 -24.63600 1.000 109.85491 ? 67  ASN F CA  1 
ATOM   326  C C   . ASN A 1 71  ? 172.46800 314.10800 -25.53000 1.000 109.04866 ? 67  ASN F C   1 
ATOM   327  O O   . ASN A 1 71  ? 171.51800 314.75000 -25.06600 1.000 106.91010 ? 67  ASN F O   1 
ATOM   328  C CB  . ASN A 1 71  ? 172.91800 312.14500 -24.03100 1.000 108.07373 ? 67  ASN F CB  1 
ATOM   329  C CG  . ASN A 1 71  ? 173.91000 311.43000 -23.12800 1.000 109.37113 ? 67  ASN F CG  1 
ATOM   330  O OD1 . ASN A 1 71  ? 175.09800 311.33700 -23.44200 1.000 111.48381 ? 67  ASN F OD1 1 
ATOM   331  N ND2 . ASN A 1 71  ? 173.42400 310.91900 -22.00000 1.000 102.70043 ? 67  ASN F ND2 1 
ATOM   332  N N   . LYS A 1 72  ? 172.68000 313.90700 -26.81700 1.000 109.39048 ? 68  LYS F N   1 
ATOM   333  C CA  . LYS A 1 72  ? 171.87900 314.46700 -27.88600 1.000 114.17907 ? 68  LYS F CA  1 
ATOM   334  C C   . LYS A 1 72  ? 171.18600 313.39900 -28.71000 1.000 114.96175 ? 68  LYS F C   1 
ATOM   335  O O   . LYS A 1 72  ? 171.81800 312.42600 -29.13900 1.000 112.88062 ? 68  LYS F O   1 
ATOM   336  C CB  . LYS A 1 72  ? 172.73900 315.34700 -28.80200 1.000 117.00896 ? 68  LYS F CB  1 
ATOM   337  C CG  . LYS A 1 72  ? 173.45800 316.48300 -28.08200 1.000 115.22087 ? 68  LYS F CG  1 
ATOM   338  C CD  . LYS A 1 72  ? 173.90900 317.55900 -29.06000 1.000 110.86163 ? 68  LYS F CD  1 
ATOM   339  C CE  . LYS A 1 72  ? 174.55800 318.73300 -28.34100 1.000 107.52912 ? 68  LYS F CE  1 
ATOM   340  N NZ  . LYS A 1 72  ? 175.04700 319.76600 -29.29800 1.000 103.59743 ? 68  LYS F NZ  1 
ATOM   341  N N   . CYS A 1 73  ? 169.87900 313.53900 -28.85700 1.000 120.01015 ? 69  CYS F N   1 
ATOM   342  C CA  . CYS A 1 73  ? 169.15300 312.65500 -29.74000 1.000 118.28845 ? 69  CYS F CA  1 
ATOM   343  C C   . CYS A 1 73  ? 168.27200 313.54900 -30.60700 1.000 115.74927 ? 69  CYS F C   1 
ATOM   344  O O   . CYS A 1 73  ? 168.06500 314.73000 -30.30400 1.000 110.64319 ? 69  CYS F O   1 
ATOM   345  C CB  . CYS A 1 73  ? 168.36900 311.61100 -28.92300 1.000 115.19011 ? 69  CYS F CB  1 
ATOM   346  S SG  . CYS A 1 73  ? 167.58100 312.23200 -27.37100 1.000 121.65862 ? 69  CYS F SG  1 
ATOM   347  N N   . ASN A 1 74  ? 167.71000 312.97500 -31.67300 1.000 118.05854 ? 70  ASN F N   1 
ATOM   348  C CA  . ASN A 1 74  ? 166.80500 313.74300 -32.52000 1.000 116.30371 ? 70  ASN F CA  1 
ATOM   349  C C   . ASN A 1 74  ? 165.63900 314.23700 -31.67100 1.000 114.23551 ? 70  ASN F C   1 
ATOM   350  O O   . ASN A 1 74  ? 164.75400 313.44500 -31.33200 1.000 118.48684 ? 70  ASN F O   1 
ATOM   351  C CB  . ASN A 1 74  ? 166.37100 312.86600 -33.70600 1.000 116.49542 ? 70  ASN F CB  1 
ATOM   352  C CG  . ASN A 1 74  ? 167.46800 312.74200 -34.78500 1.000 120.82918 ? 70  ASN F CG  1 
ATOM   353  O OD1 . ASN A 1 74  ? 168.41400 313.53300 -34.82200 1.000 126.29498 ? 70  ASN F OD1 1 
ATOM   354  N ND2 . ASN A 1 74  ? 167.35700 311.71900 -35.63500 1.000 111.30912 ? 70  ASN F ND2 1 
ATOM   355  N N   . GLY A 1 75  ? 165.58300 315.51800 -31.34600 1.000 109.16423 ? 71  GLY F N   1 
ATOM   356  C CA  . GLY A 1 75  ? 164.48600 316.04200 -30.54600 1.000 99.17959  ? 71  GLY F CA  1 
ATOM   357  C C   . GLY A 1 75  ? 163.85500 317.32800 -31.02400 1.000 90.42246  ? 71  GLY F C   1 
ATOM   358  O O   . GLY A 1 75  ? 164.54700 318.28100 -31.37900 1.000 93.88943  ? 71  GLY F O   1 
ATOM   359  N N   . THR A 1 76  ? 162.53300 317.34800 -30.99900 1.000 80.82389  ? 72  THR F N   1 
ATOM   360  C CA  . THR A 1 76  ? 161.70700 318.47900 -31.41400 1.000 77.51275  ? 72  THR F CA  1 
ATOM   361  C C   . THR A 1 76  ? 160.45300 318.63100 -30.57100 1.000 70.76629  ? 72  THR F C   1 
ATOM   362  O O   . THR A 1 76  ? 159.95800 319.75400 -30.43300 1.000 67.06867  ? 72  THR F O   1 
ATOM   363  C CB  . THR A 1 76  ? 161.32100 318.44300 -32.89300 1.000 76.24643  ? 72  THR F CB  1 
ATOM   364  O OG1 . THR A 1 76  ? 162.49400 318.64200 -33.67600 1.000 79.82646  ? 72  THR F OG1 1 
ATOM   365  C CG2 . THR A 1 76  ? 160.36000 319.58300 -33.21000 1.000 71.68806  ? 72  THR F CG2 1 
ATOM   366  N N   . ASP A 1 77  ? 159.86600 317.54300 -30.07300 1.000 65.18545  ? 73  ASP F N   1 
ATOM   367  C CA  . ASP A 1 77  ? 158.61400 317.69700 -29.35700 1.000 68.13083  ? 73  ASP F CA  1 
ATOM   368  C C   . ASP A 1 77  ? 158.81200 318.57500 -28.12300 1.000 64.20703  ? 73  ASP F C   1 
ATOM   369  O O   . ASP A 1 77  ? 159.87500 318.57600 -27.49000 1.000 58.49461  ? 73  ASP F O   1 
ATOM   370  C CB  . ASP A 1 77  ? 158.12700 316.28000 -28.98400 1.000 61.81094  ? 73  ASP F CB  1 
ATOM   371  C CG  . ASP A 1 77  ? 157.23300 316.23600 -27.75100 1.000 68.80807  ? 73  ASP F CG  1 
ATOM   372  O OD1 . ASP A 1 77  ? 156.03300 316.57600 -27.84300 1.000 67.56233  ? 73  ASP F OD1 1 
ATOM   373  O OD2 . ASP A 1 77  ? 157.73600 315.81200 -26.68300 1.000 69.06757  ? 73  ASP F OD2 1 
ATOM   374  N N   . ALA A 1 78  ? 157.76900 319.35300 -27.80000 1.000 62.74283  ? 74  ALA F N   1 
ATOM   375  C CA  . ALA A 1 78  ? 157.98100 320.41500 -26.82900 1.000 57.04377  ? 74  ALA F CA  1 
ATOM   376  C C   . ALA A 1 78  ? 158.36500 319.87200 -25.45900 1.000 57.21641  ? 74  ALA F C   1 
ATOM   377  O O   . ALA A 1 78  ? 159.16000 320.50300 -24.75100 1.000 60.14575  ? 74  ALA F O   1 
ATOM   378  C CB  . ALA A 1 78  ? 156.72600 321.27700 -26.71800 1.000 56.03732  ? 74  ALA F CB  1 
ATOM   379  N N   . LYS A 1 79  ? 157.90600 318.66000 -25.10900 1.000 56.49495  ? 75  LYS F N   1 
ATOM   380  C CA  . LYS A 1 79  ? 158.22000 318.13000 -23.78600 1.000 54.21006  ? 75  LYS F CA  1 
ATOM   381  C C   . LYS A 1 79  ? 159.70100 317.78300 -23.68900 1.000 56.96593  ? 75  LYS F C   1 
ATOM   382  O O   . LYS A 1 79  ? 160.34600 317.98900 -22.64800 1.000 56.67613  ? 75  LYS F O   1 
ATOM   383  C CB  . LYS A 1 79  ? 157.39300 316.88300 -23.43600 1.000 56.78919  ? 75  LYS F CB  1 
ATOM   384  C CG  . LYS A 1 79  ? 155.91300 317.04700 -23.01700 1.000 51.35962  ? 75  LYS F CG  1 
ATOM   385  C CD  . LYS A 1 79  ? 155.18600 315.71200 -23.36700 1.000 51.84951  ? 75  LYS F CD  1 
ATOM   386  C CE  . LYS A 1 79  ? 153.79400 315.84600 -23.90700 1.000 56.56615  ? 75  LYS F CE  1 
ATOM   387  N NZ  . LYS A 1 79  ? 153.80100 316.34700 -25.32700 1.000 68.21029  ? 75  LYS F NZ  1 
ATOM   388  N N   . VAL A 1 80  ? 160.26500 317.29900 -24.79400 1.000 58.02055  ? 76  VAL F N   1 
ATOM   389  C CA  . VAL A 1 80  ? 161.68100 316.97600 -24.83400 1.000 56.83802  ? 76  VAL F CA  1 
ATOM   390  C C   . VAL A 1 80  ? 162.51400 318.23600 -24.71500 1.000 56.04064  ? 76  VAL F C   1 
ATOM   391  O O   . VAL A 1 80  ? 163.54000 318.25200 -24.02500 1.000 55.43230  ? 76  VAL F O   1 
ATOM   392  C CB  . VAL A 1 80  ? 161.99700 316.21400 -26.13200 1.000 57.62582  ? 76  VAL F CB  1 
ATOM   393  C CG1 . VAL A 1 80  ? 163.50900 316.03600 -26.30200 1.000 54.69356  ? 76  VAL F CG1 1 
ATOM   394  C CG2 . VAL A 1 80  ? 161.22200 314.90100 -26.19200 1.000 56.71141  ? 76  VAL F CG2 1 
ATOM   395  N N   . LYS A 1 81  ? 162.09400 319.31300 -25.38000 1.000 59.04191  ? 77  LYS F N   1 
ATOM   396  C CA  . LYS A 1 81  ? 162.83600 320.56000 -25.25800 1.000 58.34616  ? 77  LYS F CA  1 
ATOM   397  C C   . LYS A 1 81  ? 162.82200 321.04800 -23.81700 1.000 62.27947  ? 77  LYS F C   1 
ATOM   398  O O   . LYS A 1 81  ? 163.84900 321.50200 -23.29400 1.000 65.06019  ? 77  LYS F O   1 
ATOM   399  C CB  . LYS A 1 81  ? 162.26900 321.62000 -26.19800 1.000 61.56714  ? 77  LYS F CB  1 
ATOM   400  C CG  . LYS A 1 81  ? 162.26500 323.00200 -25.57300 1.000 70.25850  ? 77  LYS F CG  1 
ATOM   401  C CD  . LYS A 1 81  ? 161.54300 324.01100 -26.43100 1.000 73.47808  ? 77  LYS F CD  1 
ATOM   402  C CE  . LYS A 1 81  ? 162.40800 324.36100 -27.63400 1.000 76.77661  ? 77  LYS F CE  1 
ATOM   403  N NZ  . LYS A 1 81  ? 161.79000 325.42000 -28.48900 1.000 83.39197  ? 77  LYS F NZ  1 
ATOM   404  N N   . LEU A 1 82  ? 161.66900 320.96300 -23.15400 1.000 62.08620  ? 78  LEU F N   1 
ATOM   405  C CA  . LEU A 1 82  ? 161.60300 321.44200 -21.77600 1.000 55.96241  ? 78  LEU F CA  1 
ATOM   406  C C   . LEU A 1 82  ? 162.52900 320.61100 -20.88400 1.000 55.67236  ? 78  LEU F C   1 
ATOM   407  O O   . LEU A 1 82  ? 163.26000 321.15700 -20.04300 1.000 54.59107  ? 78  LEU F O   1 
ATOM   408  C CB  . LEU A 1 82  ? 160.15400 321.37700 -21.29000 1.000 52.70157  ? 78  LEU F CB  1 
ATOM   409  C CG  . LEU A 1 82  ? 159.24100 322.43700 -21.93800 1.000 50.26486  ? 78  LEU F CG  1 
ATOM   410  C CD1 . LEU A 1 82  ? 157.78100 322.18400 -21.62200 1.000 44.40564  ? 78  LEU F CD1 1 
ATOM   411  C CD2 . LEU A 1 82  ? 159.63200 323.84300 -21.53200 1.000 55.63800  ? 78  LEU F CD2 1 
ATOM   412  N N   . ILE A 1 83  ? 162.56300 319.29000 -21.10900 1.000 58.31757  ? 79  ILE F N   1 
ATOM   413  C CA  . ILE A 1 83  ? 163.43700 318.42000 -20.32700 1.000 49.25297  ? 79  ILE F CA  1 
ATOM   414  C C   . ILE A 1 83  ? 164.89800 318.77400 -20.56400 1.000 53.87038  ? 79  ILE F C   1 
ATOM   415  O O   . ILE A 1 83  ? 165.68100 318.87300 -19.61600 1.000 57.34897  ? 79  ILE F O   1 
ATOM   416  C CB  . ILE A 1 83  ? 163.16000 316.94000 -20.65200 1.000 48.61407  ? 79  ILE F CB  1 
ATOM   417  C CG1 . ILE A 1 83  ? 161.94600 316.41900 -19.89100 1.000 46.84214  ? 79  ILE F CG1 1 
ATOM   418  C CG2 . ILE A 1 83  ? 164.36200 316.06900 -20.28400 1.000 51.94062  ? 79  ILE F CG2 1 
ATOM   419  C CD1 . ILE A 1 83  ? 162.10900 316.47200 -18.38100 1.000 49.01777  ? 79  ILE F CD1 1 
ATOM   420  N N   . LYS A 1 84  ? 165.30500 318.93900 -21.82800 1.000 55.96784  ? 80  LYS F N   1 
ATOM   421  C CA  . LYS A 1 84  ? 166.71400 319.28000 -22.06100 1.000 59.59771  ? 80  LYS F CA  1 
ATOM   422  C C   . LYS A 1 84  ? 167.09000 320.65400 -21.51000 1.000 56.52186  ? 80  LYS F C   1 
ATOM   423  O O   . LYS A 1 84  ? 168.21700 320.83600 -21.04200 1.000 53.77395  ? 80  LYS F O   1 
ATOM   424  C CB  . LYS A 1 84  ? 167.15500 319.14400 -23.52400 1.000 57.62279  ? 80  LYS F CB  1 
ATOM   425  C CG  . LYS A 1 84  ? 167.07900 317.70700 -24.09000 1.000 57.96083  ? 80  LYS F CG  1 
ATOM   426  C CD  . LYS A 1 84  ? 167.37500 317.62600 -25.59900 1.000 56.57530  ? 80  LYS F CD  1 
ATOM   427  C CE  . LYS A 1 84  ? 166.20700 317.78500 -26.51900 1.000 65.35631  ? 80  LYS F CE  1 
ATOM   428  N NZ  . LYS A 1 84  ? 166.63300 317.39800 -27.90400 1.000 77.60768  ? 80  LYS F NZ  1 
ATOM   429  N N   . GLN A 1 85  ? 166.16900 321.61400 -21.50700 1.000 57.41458  ? 81  GLN F N   1 
ATOM   430  C CA  . GLN A 1 85  ? 166.46200 322.91400 -20.90300 1.000 51.13521  ? 81  GLN F CA  1 
ATOM   431  C C   . GLN A 1 85  ? 166.69500 322.79800 -19.40000 1.000 54.71329  ? 81  GLN F C   1 
ATOM   432  O O   . GLN A 1 85  ? 167.69800 323.30100 -18.86600 1.000 60.22856  ? 81  GLN F O   1 
ATOM   433  C CB  . GLN A 1 85  ? 165.27200 323.84600 -21.13100 1.000 51.85884  ? 81  GLN F CB  1 
ATOM   434  C CG  . GLN A 1 85  ? 165.10000 324.44100 -22.49700 1.000 59.06304  ? 81  GLN F CG  1 
ATOM   435  C CD  . GLN A 1 85  ? 163.97300 325.46800 -22.50600 1.000 70.68285  ? 81  GLN F CD  1 
ATOM   436  O OE1 . GLN A 1 85  ? 163.03400 325.37500 -21.71000 1.000 72.03133  ? 81  GLN F OE1 1 
ATOM   437  N NE2 . GLN A 1 85  ? 164.04100 326.43400 -23.42700 1.000 74.94658  ? 81  GLN F NE2 1 
ATOM   438  N N   . GLU A 1 86  ? 165.77500 322.13700 -18.69000 1.000 51.02836  ? 82  GLU F N   1 
ATOM   439  C CA  . GLU A 1 86  ? 165.98800 321.98500 -17.25500 1.000 49.80241  ? 82  GLU F CA  1 
ATOM   440  C C   . GLU A 1 86  ? 167.21500 321.10700 -16.97000 1.000 56.01172  ? 82  GLU F C   1 
ATOM   441  O O   . GLU A 1 86  ? 167.95600 321.33700 -15.99700 1.000 56.68413  ? 82  GLU F O   1 
ATOM   442  C CB  . GLU A 1 86  ? 164.72000 321.41400 -16.63000 1.000 50.31698  ? 82  GLU F CB  1 
ATOM   443  C CG  . GLU A 1 86  ? 164.66400 321.38700 -15.10900 1.000 51.02103  ? 82  GLU F CG  1 
ATOM   444  C CD  . GLU A 1 86  ? 164.56700 322.81300 -14.50600 1.000 61.01765  ? 82  GLU F CD  1 
ATOM   445  O OE1 . GLU A 1 86  ? 164.12400 323.74300 -15.23900 1.000 61.27738  ? 82  GLU F OE1 1 
ATOM   446  O OE2 . GLU A 1 86  ? 164.90400 323.00500 -13.30300 1.000 61.62754  ? 82  GLU F OE2 1 
ATOM   447  N N   . LEU A 1 87  ? 167.50500 320.15600 -17.85600 1.000 52.12920  ? 83  LEU F N   1 
ATOM   448  C CA  . LEU A 1 87  ? 168.67400 319.31000 -17.68000 1.000 52.62643  ? 83  LEU F CA  1 
ATOM   449  C C   . LEU A 1 87  ? 169.95300 320.10800 -17.88900 1.000 59.80414  ? 83  LEU F C   1 
ATOM   450  O O   . LEU A 1 87  ? 170.97400 319.84300 -17.23700 1.000 58.23102  ? 83  LEU F O   1 
ATOM   451  C CB  . LEU A 1 87  ? 168.56000 318.09800 -18.60100 1.000 57.54541  ? 83  LEU F CB  1 
ATOM   452  C CG  . LEU A 1 87  ? 169.23900 316.81600 -18.10600 1.000 56.39418  ? 83  LEU F CG  1 
ATOM   453  C CD1 . LEU A 1 87  ? 168.58700 316.35500 -16.81800 1.000 57.05882  ? 83  LEU F CD1 1 
ATOM   454  C CD2 . LEU A 1 87  ? 169.03000 315.74400 -19.14700 1.000 62.11208  ? 83  LEU F CD2 1 
ATOM   455  N N   . ASP A 1 88  ? 169.90100 321.11100 -18.77200 1.000 62.90454  ? 84  ASP F N   1 
ATOM   456  C CA  . ASP A 1 88  ? 171.04900 321.98200 -18.98900 1.000 60.11821  ? 84  ASP F CA  1 
ATOM   457  C C   . ASP A 1 88  ? 171.27500 322.85700 -17.76200 1.000 61.51228  ? 84  ASP F C   1 
ATOM   458  O O   . ASP A 1 88  ? 172.41900 323.06500 -17.32600 1.000 63.29663  ? 84  ASP F O   1 
ATOM   459  C CB  . ASP A 1 88  ? 170.75500 322.84800 -20.22300 1.000 63.15764  ? 84  ASP F CB  1 
ATOM   460  C CG  . ASP A 1 88  ? 171.97100 323.62300 -20.75400 1.000 82.15067  ? 84  ASP F CG  1 
ATOM   461  O OD1 . ASP A 1 88  ? 172.97800 323.81100 -20.03200 1.000 85.25234  ? 84  ASP F OD1 1 
ATOM   462  O OD2 . ASP A 1 88  ? 171.89200 324.06700 -21.93200 1.000 78.48785  ? 84  ASP F OD2 1 
ATOM   463  N N   . LYS A 1 89  ? 170.19000 323.27100 -17.11500 1.000 60.53130  ? 85  LYS F N   1 
ATOM   464  C CA  . LYS A 1 89  ? 170.35000 324.00000 -15.86000 1.000 59.02013  ? 85  LYS F CA  1 
ATOM   465  C C   . LYS A 1 89  ? 170.96000 323.12900 -14.75200 1.000 59.51205  ? 85  LYS F C   1 
ATOM   466  O O   . LYS A 1 89  ? 171.78500 323.60600 -13.95600 1.000 63.21562  ? 85  LYS F O   1 
ATOM   467  C CB  . LYS A 1 89  ? 168.98000 324.50200 -15.40300 1.000 58.04258  ? 85  LYS F CB  1 
ATOM   468  C CG  . LYS A 1 89  ? 168.42100 325.68300 -16.16200 1.000 57.44965  ? 85  LYS F CG  1 
ATOM   469  C CD  . LYS A 1 89  ? 167.18400 326.22000 -15.45600 1.000 59.17892  ? 85  LYS F CD  1 
ATOM   470  C CE  . LYS A 1 89  ? 167.06100 327.72300 -15.62400 1.000 65.15890  ? 85  LYS F CE  1 
ATOM   471  N NZ  . LYS A 1 89  ? 166.40800 328.05400 -16.93100 1.000 67.68567  ? 85  LYS F NZ  1 
ATOM   472  N N   . TYR A 1 90  ? 170.66600 321.82500 -14.76600 1.000 62.29060  ? 86  TYR F N   1 
ATOM   473  C CA  . TYR A 1 90  ? 171.33400 320.88700 -13.85500 1.000 61.47819  ? 86  TYR F CA  1 
ATOM   474  C C   . TYR A 1 90  ? 172.82000 320.70900 -14.17900 1.000 59.96409  ? 86  TYR F C   1 
ATOM   475  O O   . TYR A 1 90  ? 173.67500 320.72300 -13.27100 1.000 53.38704  ? 86  TYR F O   1 
ATOM   476  C CB  . TYR A 1 90  ? 170.59500 319.54600 -13.93300 1.000 57.43176  ? 86  TYR F CB  1 
ATOM   477  C CG  . TYR A 1 90  ? 171.27100 318.37500 -13.27600 1.000 50.16201  ? 86  TYR F CG  1 
ATOM   478  C CD1 . TYR A 1 90  ? 171.12200 318.11400 -11.92000 1.000 44.49284  ? 86  TYR F CD1 1 
ATOM   479  C CD2 . TYR A 1 90  ? 172.10700 317.55700 -14.02100 1.000 51.45247  ? 86  TYR F CD2 1 
ATOM   480  C CE1 . TYR A 1 90  ? 171.76900 317.04400 -11.33800 1.000 46.46594  ? 86  TYR F CE1 1 
ATOM   481  C CE2 . TYR A 1 90  ? 172.75300 316.50300 -13.45500 1.000 49.72801  ? 86  TYR F CE2 1 
ATOM   482  C CZ  . TYR A 1 90  ? 172.59100 316.24500 -12.12500 1.000 52.79663  ? 86  TYR F CZ  1 
ATOM   483  O OH  . TYR A 1 90  ? 173.26800 315.16600 -11.61000 1.000 62.16976  ? 86  TYR F OH  1 
ATOM   484  N N   . LYS A 1 91  ? 173.16600 320.68900 -15.46500 1.000 62.05637  ? 87  LYS F N   1 
ATOM   485  C CA  . LYS A 1 91  ? 174.56600 320.45300 -15.79600 1.000 61.21896  ? 87  LYS F CA  1 
ATOM   486  C C   . LYS A 1 91  ? 175.40300 321.65400 -15.40300 1.000 64.34197  ? 87  LYS F C   1 
ATOM   487  O O   . LYS A 1 91  ? 176.52900 321.51000 -14.90300 1.000 69.35975  ? 87  LYS F O   1 
ATOM   488  C CB  . LYS A 1 91  ? 174.73300 320.17700 -17.29600 1.000 65.69042  ? 87  LYS F CB  1 
ATOM   489  C CG  . LYS A 1 91  ? 174.92300 318.70300 -17.71400 1.000 64.88637  ? 87  LYS F CG  1 
ATOM   490  C CD  . LYS A 1 91  ? 176.24400 318.13900 -17.11900 1.000 77.19726  ? 87  LYS F CD  1 
ATOM   491  C CE  . LYS A 1 91  ? 177.48000 318.89700 -17.61900 1.000 74.42860  ? 87  LYS F CE  1 
ATOM   492  N NZ  . LYS A 1 91  ? 178.74000 318.47500 -16.93300 1.000 67.50841  ? 87  LYS F NZ  1 
ATOM   493  N N   . ASN A 1 92  ? 174.85500 322.84900 -15.60600 1.000 66.62334  ? 88  ASN F N   1 
ATOM   494  C CA  . ASN A 1 92  ? 175.57900 324.05000 -15.22600 1.000 61.82252  ? 88  ASN F CA  1 
ATOM   495  C C   . ASN A 1 92  ? 175.66100 324.19800 -13.71200 1.000 58.62319  ? 88  ASN F C   1 
ATOM   496  O O   . ASN A 1 92  ? 176.69300 324.61700 -13.18700 1.000 60.65329  ? 88  ASN F O   1 
ATOM   497  C CB  . ASN A 1 92  ? 174.93500 325.26300 -15.88300 1.000 66.39278  ? 88  ASN F CB  1 
ATOM   498  C CG  . ASN A 1 92  ? 175.54900 325.56700 -17.24400 1.000 75.49475  ? 88  ASN F CG  1 
ATOM   499  O OD1 . ASN A 1 92  ? 174.85100 325.63900 -18.25900 1.000 69.70843  ? 88  ASN F OD1 1 
ATOM   500  N ND2 . ASN A 1 92  ? 176.87000 325.74900 -17.26700 1.000 79.70885  ? 88  ASN F ND2 1 
ATOM   501  N N   . ALA A 1 93  ? 174.60400 323.87500 -12.97600 1.000 57.80089  ? 89  ALA F N   1 
ATOM   502  C CA  . ALA A 1 93  ? 174.77400 323.89800 -11.52700 1.000 56.73060  ? 89  ALA F CA  1 
ATOM   503  C C   . ALA A 1 93  ? 175.92600 322.98700 -11.09400 1.000 60.50375  ? 89  ALA F C   1 
ATOM   504  O O   . ALA A 1 93  ? 176.68900 323.32100 -10.18000 1.000 63.06519  ? 89  ALA F O   1 
ATOM   505  C CB  . ALA A 1 93  ? 173.48200 323.49600 -10.82700 1.000 53.95006  ? 89  ALA F CB  1 
ATOM   506  N N   . VAL A 1 94  ? 176.10000 321.84000 -11.75500 1.000 65.27461  ? 90  VAL F N   1 
ATOM   507  C CA  . VAL A 1 94  ? 177.22100 320.97200 -11.37100 1.000 64.82694  ? 90  VAL F CA  1 
ATOM   508  C C   . VAL A 1 94  ? 178.57900 321.56100 -11.76800 1.000 68.57368  ? 90  VAL F C   1 
ATOM   509  O O   . VAL A 1 94  ? 179.52100 321.58300 -10.95700 1.000 66.07686  ? 90  VAL F O   1 
ATOM   510  C CB  . VAL A 1 94  ? 177.04000 319.56500 -11.96200 1.000 59.48139  ? 90  VAL F CB  1 
ATOM   511  C CG1 . VAL A 1 94  ? 178.26600 318.74000 -11.71900 1.000 64.84675  ? 90  VAL F CG1 1 
ATOM   512  C CG2 . VAL A 1 94  ? 175.87600 318.91700 -11.34300 1.000 56.13314  ? 90  VAL F CG2 1 
ATOM   513  N N   . THR A 1 95  ? 178.69500 322.13800 -12.96200 1.000 64.82134  ? 91  THR F N   1 
ATOM   514  C CA  . THR A 1 95  ? 180.01500 322.66200 -13.27500 1.000 64.36951  ? 91  THR F CA  1 
ATOM   515  C C   . THR A 1 95  ? 180.33200 323.87700 -12.40000 1.000 69.34716  ? 91  THR F C   1 
ATOM   516  O O   . THR A 1 95  ? 181.49700 324.10800 -12.05900 1.000 76.75968  ? 91  THR F O   1 
ATOM   517  C CB  . THR A 1 95  ? 180.12100 322.98300 -14.77300 1.000 64.29857  ? 91  THR F CB  1 
ATOM   518  O OG1 . THR A 1 95  ? 179.18100 323.99500 -15.13900 1.000 71.47497  ? 91  THR F OG1 1 
ATOM   519  C CG2 . THR A 1 95  ? 179.78800 321.73200 -15.59400 1.000 60.21592  ? 91  THR F CG2 1 
ATOM   520  N N   . ASP A 1 96  ? 179.31900 324.65400 -12.01800 1.000 64.71169  ? 92  ASP F N   1 
ATOM   521  C CA  . ASP A 1 96  ? 179.52700 325.78300 -11.11900 1.000 62.10578  ? 92  ASP F CA  1 
ATOM   522  C C   . ASP A 1 96  ? 179.93300 325.34800 -9.71100  1.000 63.06924  ? 92  ASP F C   1 
ATOM   523  O O   . ASP A 1 96  ? 180.82200 325.95900 -9.10400  1.000 72.79707  ? 92  ASP F O   1 
ATOM   524  C CB  . ASP A 1 96  ? 178.27700 326.65400 -11.09500 1.000 69.35557  ? 92  ASP F CB  1 
ATOM   525  C CG  . ASP A 1 96  ? 178.14800 327.53000 -12.34700 1.000 74.26849  ? 92  ASP F CG  1 
ATOM   526  O OD1 . ASP A 1 96  ? 178.98400 327.40000 -13.28400 1.000 70.23332  ? 92  ASP F OD1 1 
ATOM   527  O OD2 . ASP A 1 96  ? 177.18500 328.33000 -12.39700 1.000 74.81524  ? 92  ASP F OD2 1 
ATOM   528  N N   . LEU A 1 97  ? 179.33800 324.28000 -9.17500  1.000 61.44143  ? 93  LEU F N   1 
ATOM   529  C CA  . LEU A 1 97  ? 179.82000 323.85700 -7.86100  1.000 64.15219  ? 93  LEU F CA  1 
ATOM   530  C C   . LEU A 1 97  ? 181.22700 323.32700 -7.98400  1.000 65.31294  ? 93  LEU F C   1 
ATOM   531  O O   . LEU A 1 97  ? 182.02400 323.41100 -7.03400  1.000 65.47577  ? 93  LEU F O   1 
ATOM   532  C CB  . LEU A 1 97  ? 178.91400 322.81700 -7.21100  1.000 59.48396  ? 93  LEU F CB  1 
ATOM   533  C CG  . LEU A 1 97  ? 177.57200 323.32500 -6.69800  1.000 58.94510  ? 93  LEU F CG  1 
ATOM   534  C CD1 . LEU A 1 97  ? 176.81000 322.18300 -6.07300  1.000 56.82414  ? 93  LEU F CD1 1 
ATOM   535  C CD2 . LEU A 1 97  ? 177.74900 324.45100 -5.68800  1.000 58.66986  ? 93  LEU F CD2 1 
ATOM   536  N N   . GLN A 1 98  ? 181.57700 322.88800 -9.18100  1.000 70.13159  ? 94  GLN F N   1 
ATOM   537  C CA  . GLN A 1 98  ? 182.91800 322.37700 -9.37900  1.000 73.75931  ? 94  GLN F CA  1 
ATOM   538  C C   . GLN A 1 98  ? 183.91700 323.53400 -9.44000  1.000 74.98568  ? 94  GLN F C   1 
ATOM   539  O O   . GLN A 1 98  ? 184.98000 323.45400 -8.81000  1.000 73.06530  ? 94  GLN F O   1 
ATOM   540  C CB  . GLN A 1 98  ? 182.95100 321.47100 -10.60800 1.000 70.49844  ? 94  GLN F CB  1 
ATOM   541  C CG  . GLN A 1 98  ? 182.29300 320.11900 -10.31600 1.000 70.70066  ? 94  GLN F CG  1 
ATOM   542  C CD  . GLN A 1 98  ? 182.24000 319.19900 -11.52300 1.000 76.25832  ? 94  GLN F CD  1 
ATOM   543  O OE1 . GLN A 1 98  ? 182.26300 319.65300 -12.67300 1.000 75.03708  ? 94  GLN F OE1 1 
ATOM   544  N NE2 . GLN A 1 98  ? 182.21800 317.88900 -11.26500 1.000 71.41645  ? 94  GLN F NE2 1 
ATOM   545  N N   . LEU A 1 99  ? 183.59900 324.63000 -10.15200 1.000 74.92807  ? 95  LEU F N   1 
ATOM   546  C CA  . LEU A 1 99  ? 184.55000 325.74000 -10.12600 1.000 72.24718  ? 95  LEU F CA  1 
ATOM   547  C C   . LEU A 1 99  ? 184.57200 326.42400 -8.77600  1.000 73.58357  ? 95  LEU F C   1 
ATOM   548  O O   . LEU A 1 99  ? 185.53900 327.12500 -8.46500  1.000 85.21086  ? 95  LEU F O   1 
ATOM   549  C CB  . LEU A 1 99  ? 184.18300 326.85000 -11.11300 1.000 62.23528  ? 95  LEU F CB  1 
ATOM   550  C CG  . LEU A 1 99  ? 184.04700 326.70000 -12.61400 1.000 76.12551  ? 95  LEU F CG  1 
ATOM   551  C CD1 . LEU A 1 99  ? 183.82300 328.08900 -13.22300 1.000 64.61326  ? 95  LEU F CD1 1 
ATOM   552  C CD2 . LEU A 1 99  ? 185.29000 326.03100 -13.17800 1.000 79.71205  ? 95  LEU F CD2 1 
ATOM   553  N N   . LEU A 1 100 ? 183.54000 326.24100 -7.96200  1.000 70.43300  ? 96  LEU F N   1 
ATOM   554  C CA  . LEU A 1 100 ? 183.62100 326.77300 -6.61300  1.000 74.62620  ? 96  LEU F CA  1 
ATOM   555  C C   . LEU A 1 100 ? 184.55900 325.93900 -5.74300  1.000 73.14621  ? 96  LEU F C   1 
ATOM   556  O O   . LEU A 1 100 ? 185.21300 326.47900 -4.84900  1.000 79.17463  ? 96  LEU F O   1 
ATOM   557  C CB  . LEU A 1 100 ? 182.21800 326.85900 -6.00900  1.000 73.51326  ? 96  LEU F CB  1 
ATOM   558  C CG  . LEU A 1 100 ? 182.01300 327.37800 -4.59000  1.000 60.17045  ? 96  LEU F CG  1 
ATOM   559  C CD1 . LEU A 1 100 ? 180.54600 327.63800 -4.42800  1.000 64.04930  ? 96  LEU F CD1 1 
ATOM   560  C CD2 . LEU A 1 100 ? 182.48500 326.38900 -3.55800  1.000 68.39965  ? 96  LEU F CD2 1 
ATOM   561  N N   . MET A 1 101 ? 184.64400 324.62600 -5.99600  1.000 75.12148  ? 97  MET F N   1 
ATOM   562  C CA  . MET A 1 101 ? 185.50300 323.75500 -5.18900  1.000 77.45735  ? 97  MET F CA  1 
ATOM   563  C C   . MET A 1 101 ? 186.93900 323.59700 -5.67900  1.000 85.41829  ? 97  MET F C   1 
ATOM   564  O O   . MET A 1 101 ? 187.80600 323.18800 -4.89400  1.000 85.86340  ? 97  MET F O   1 
ATOM   565  C CB  . MET A 1 101 ? 184.90300 322.35600 -5.05700  1.000 80.40843  ? 97  MET F CB  1 
ATOM   566  C CG  . MET A 1 101 ? 185.33700 321.88100 -3.73500  1.000 85.08006  ? 97  MET F CG  1 
ATOM   567  S SD  . MET A 1 101 ? 183.97600 322.43400 -2.72100  1.000 95.18596  ? 97  MET F SD  1 
ATOM   568  C CE  . MET A 1 101 ? 184.76000 322.48500 -1.10100  1.000 85.24785  ? 97  MET F CE  1 
ATOM   569  N N   . GLN A 1 102 ? 187.20100 323.90900 -6.94300  1.000 88.40626  ? 98  GLN F N   1 
ATOM   570  C CA  . GLN A 1 102 ? 188.56400 323.95000 -7.47000  1.000 86.08196  ? 98  GLN F CA  1 
ATOM   571  C C   . GLN A 1 102 ? 189.42800 324.99500 -6.76500  1.000 91.89621  ? 98  GLN F C   1 
ATOM   572  O O   . GLN A 1 102 ? 190.58100 324.72500 -6.40100  1.000 97.12267  ? 98  GLN F O   1 
ATOM   573  C CB  . GLN A 1 102 ? 188.50900 324.23200 -8.97200  1.000 79.14849  ? 98  GLN F CB  1 
ATOM   574  C CG  . GLN A 1 102 ? 189.82000 324.08800 -9.71600  1.000 86.78586  ? 98  GLN F CG  1 
ATOM   575  C CD  . GLN A 1 102 ? 189.74700 324.71400 -11.09400 1.000 92.94944  ? 98  GLN F CD  1 
ATOM   576  O OE1 . GLN A 1 102 ? 188.69500 325.20600 -11.50200 1.000 92.73080  ? 98  GLN F OE1 1 
ATOM   577  N NE2 . GLN A 1 102 ? 190.86000 324.69500 -11.82200 1.000 94.47011  ? 98  GLN F NE2 1 
ATOM   578  N N   . SER A 1 103 ? 188.85900 326.15800 -6.48900  1.000 83.80443  ? 99  SER F N   1 
ATOM   579  C CA  . SER A 1 103 ? 189.54400 327.25800 -5.81800  1.000 89.86114  ? 99  SER F CA  1 
ATOM   580  C C   . SER A 1 103 ? 188.58200 327.80000 -4.78000  1.000 89.50756  ? 99  SER F C   1 
ATOM   581  O O   . SER A 1 103 ? 187.57400 328.42300 -5.13500  1.000 89.23278  ? 99  SER F O   1 
ATOM   582  C CB  . SER A 1 103 ? 189.95900 328.36000 -6.80700  1.000 94.26072  ? 99  SER F CB  1 
ATOM   583  O OG  . SER A 1 103 ? 188.82800 329.00000 -7.40400  1.000 90.37839  ? 99  SER F OG  1 
ATOM   584  N N   . THR A 1 104 ? 188.89600 327.58200 -3.49800  1.000 88.85680  ? 100 THR F N   1 
ATOM   585  C CA  . THR A 1 104 ? 187.96100 328.03200 -2.48100  1.000 92.95243  ? 100 THR F CA  1 
ATOM   586  C C   . THR A 1 104 ? 188.52400 329.27700 -1.80900  1.000 89.30747  ? 100 THR F C   1 
ATOM   587  O O   . THR A 1 104 ? 189.58500 329.22700 -1.16100  1.000 84.84091  ? 100 THR F O   1 
ATOM   588  C CB  . THR A 1 104 ? 187.79200 326.90600 -1.44000  1.000 99.64029  ? 100 THR F CB  1 
ATOM   589  O OG1 . THR A 1 104 ? 187.25900 325.71100 -2.04600  1.000 84.77607  ? 100 THR F OG1 1 
ATOM   590  C CG2 . THR A 1 104 ? 186.93500 327.34600 -0.23000  1.000 94.36743  ? 100 THR F CG2 1 
ATOM   591  N N   . PRO A 1 105 ? 187.82900 330.40800 -1.98500  1.000 90.36436  ? 101 PRO F N   1 
ATOM   592  C CA  . PRO A 1 105 ? 188.24800 331.68200 -1.38000  1.000 82.85250  ? 101 PRO F CA  1 
ATOM   593  C C   . PRO A 1 105 ? 188.11400 331.70600 0.14200   1.000 82.78465  ? 101 PRO F C   1 
ATOM   594  O O   . PRO A 1 105 ? 187.18200 331.13100 0.71400   1.000 90.07574  ? 101 PRO F O   1 
ATOM   595  C CB  . PRO A 1 105 ? 187.33400 332.72100 -2.05900  1.000 80.20222  ? 101 PRO F CB  1 
ATOM   596  C CG  . PRO A 1 105 ? 186.80300 332.04800 -3.31600  1.000 77.09544  ? 101 PRO F CG  1 
ATOM   597  C CD  . PRO A 1 105 ? 186.71400 330.58100 -2.94000  1.000 92.51901  ? 101 PRO F CD  1 
ATOM   598  N N   . ALA A 1 106 ? 189.08100 332.34400 0.79900   1.000 78.57818  ? 102 ALA F N   1 
ATOM   599  C CA  . ALA A 1 106 ? 189.03300 332.47900 2.24800   1.000 74.69945  ? 102 ALA F CA  1 
ATOM   600  C C   . ALA A 1 106 ? 187.88100 333.39100 2.66600   1.000 81.34535  ? 102 ALA F C   1 
ATOM   601  O O   . ALA A 1 106 ? 187.45300 334.27900 1.92000   1.000 81.56635  ? 102 ALA F O   1 
ATOM   602  C CB  . ALA A 1 106 ? 190.35300 333.03100 2.79400   1.000 52.19766  ? 102 ALA F CB  1 
ATOM   603  N N   . THR A 1 107 ? 187.30300 333.07400 3.82200   1.000 89.66070  ? 103 THR F N   1 
ATOM   604  C CA  . THR A 1 107 ? 186.19100 333.78900 4.43300   1.000 87.06513  ? 103 THR F CA  1 
ATOM   605  C C   . THR A 1 107 ? 186.59700 334.30000 5.81500   1.000 87.79686  ? 103 THR F C   1 
ATOM   606  O O   . THR A 1 107 ? 187.60600 333.87100 6.39100   1.000 88.06207  ? 103 THR F O   1 
ATOM   607  C CB  . THR A 1 107 ? 184.93400 332.90300 4.55200   1.000 85.77834  ? 103 THR F CB  1 
ATOM   608  O OG1 . THR A 1 107 ? 185.22200 331.74300 5.35500   1.000 79.80806  ? 103 THR F OG1 1 
ATOM   609  C CG2 . THR A 1 107 ? 184.42200 332.47700 3.16800   1.000 85.96145  ? 103 THR F CG2 1 
ATOM   610  N N   . GLY A 1 108 ? 185.85300 335.29500 6.30300   1.000 90.76276  ? 143 GLY F N   1 
ATOM   611  C CA  . GLY A 1 108 ? 186.03800 335.80400 7.65700   1.000 87.13011  ? 143 GLY F CA  1 
ATOM   612  C C   . GLY A 1 108 ? 185.57000 334.85400 8.75400   1.000 85.10764  ? 143 GLY F C   1 
ATOM   613  O O   . GLY A 1 108 ? 185.69500 335.18700 9.93900   1.000 85.29161  ? 143 GLY F O   1 
ATOM   614  N N   . SER A 1 109 ? 185.01300 333.69300 8.37000   1.000 77.62165  ? 144 SER F N   1 
ATOM   615  C CA  . SER A 1 109 ? 184.51400 332.64200 9.25800   1.000 70.00065  ? 144 SER F CA  1 
ATOM   616  C C   . SER A 1 109 ? 185.49700 331.48600 9.50300   1.000 68.62761  ? 144 SER F C   1 
ATOM   617  O O   . SER A 1 109 ? 185.10800 330.48200 10.12400  1.000 60.24934  ? 144 SER F O   1 
ATOM   618  C CB  . SER A 1 109 ? 183.18700 332.08500 8.72200   1.000 67.65083  ? 144 SER F CB  1 
ATOM   619  O OG  . SER A 1 109 ? 182.22600 333.10500 8.49200   1.000 64.07120  ? 144 SER F OG  1 
ATOM   620  N N   . GLY A 1 110 ? 186.74300 331.57700 9.02000   1.000 66.08559  ? 145 GLY F N   1 
ATOM   621  C CA  . GLY A 1 110 ? 187.66300 330.46300 9.19400   1.000 60.38838  ? 145 GLY F CA  1 
ATOM   622  C C   . GLY A 1 110 ? 187.97100 330.12700 10.64700  1.000 62.97554  ? 145 GLY F C   1 
ATOM   623  O O   . GLY A 1 110 ? 188.17400 328.95000 10.97900  1.000 59.58851  ? 145 GLY F O   1 
ATOM   624  N N   . SER A 1 111 ? 187.92000 331.13400 11.54400  1.000 59.70976  ? 146 SER F N   1 
ATOM   625  C CA  . SER A 1 111 ? 188.16100 330.97400 12.98100  1.000 56.51194  ? 146 SER F CA  1 
ATOM   626  C C   . SER A 1 111 ? 187.02200 330.29200 13.70600  1.000 56.93354  ? 146 SER F C   1 
ATOM   627  O O   . SER A 1 111 ? 187.15100 330.01400 14.90600  1.000 51.39106  ? 146 SER F O   1 
ATOM   628  C CB  . SER A 1 111 ? 188.38300 332.33400 13.65400  1.000 54.33555  ? 146 SER F CB  1 
ATOM   629  O OG  . SER A 1 111 ? 189.58300 332.93600 13.22000  1.000 56.53509  ? 146 SER F OG  1 
ATOM   630  N N   . ALA A 1 112 ? 185.93100 329.99200 13.01900  1.000 53.75454  ? 147 ALA F N   1 
ATOM   631  C CA  . ALA A 1 112 ? 184.78600 329.37300 13.64300  1.000 51.14768  ? 147 ALA F CA  1 
ATOM   632  C C   . ALA A 1 112 ? 184.36400 328.07900 12.98800  1.000 55.09104  ? 147 ALA F C   1 
ATOM   633  O O   . ALA A 1 112 ? 183.42300 327.44100 13.49500  1.000 60.59753  ? 147 ALA F O   1 
ATOM   634  C CB  . ALA A 1 112 ? 183.60300 330.34900 13.60200  1.000 51.21616  ? 147 ALA F CB  1 
ATOM   635  N N   . ILE A 1 113 ? 185.04900 327.64900 11.91700  1.000 59.32360  ? 148 ILE F N   1 
ATOM   636  C CA  . ILE A 1 113 ? 184.66000 326.47200 11.14300  1.000 62.55944  ? 148 ILE F CA  1 
ATOM   637  C C   . ILE A 1 113 ? 185.67800 325.31600 11.14100  1.000 64.13989  ? 148 ILE F C   1 
ATOM   638  O O   . ILE A 1 113 ? 185.57400 324.43800 10.25000  1.000 62.17118  ? 148 ILE F O   1 
ATOM   639  C CB  . ILE A 1 113 ? 184.34400 326.89600 9.69700   1.000 56.13242  ? 148 ILE F CB  1 
ATOM   640  C CG1 . ILE A 1 113 ? 185.57600 327.53500 9.09500   1.000 54.85068  ? 148 ILE F CG1 1 
ATOM   641  C CG2 . ILE A 1 113 ? 183.20500 327.88400 9.69000   1.000 46.93507  ? 148 ILE F CG2 1 
ATOM   642  C CD1 . ILE A 1 113 ? 185.40600 327.92500 7.66900   1.000 63.01963  ? 148 ILE F CD1 1 
ATOM   643  N N   . CYS A 1 114 ? 186.67600 325.23600 12.04200  1.000 59.27419  ? 149 CYS F N   1 
ATOM   644  C CA  . CYS A 1 114 ? 187.55200 324.06600 11.89800  1.000 66.48200  ? 149 CYS F CA  1 
ATOM   645  C C   . CYS A 1 114 ? 186.73200 322.79200 12.03000  1.000 60.61824  ? 149 CYS F C   1 
ATOM   646  O O   . CYS A 1 114 ? 186.99900 321.80100 11.34700  1.000 61.94553  ? 149 CYS F O   1 
ATOM   647  C CB  . CYS A 1 114 ? 188.66400 323.94600 12.95800  1.000 74.31519  ? 149 CYS F CB  1 
ATOM   648  S SG  . CYS A 1 114 ? 188.79700 325.14400 14.26000  1.000 66.80847  ? 149 CYS F SG  1 
ATOM   649  N N   . SER A 1 115 ? 185.73000 322.79000 12.91500  1.000 61.68416  ? 150 SER F N   1 
ATOM   650  C CA  . SER A 1 115 ? 184.98100 321.56100 13.15200  1.000 59.31017  ? 150 SER F CA  1 
ATOM   651  C C   . SER A 1 115 ? 184.41900 321.01100 11.85400  1.000 64.48875  ? 150 SER F C   1 
ATOM   652  O O   . SER A 1 115 ? 184.53900 319.81400 11.58500  1.000 71.78051  ? 150 SER F O   1 
ATOM   653  C CB  . SER A 1 115 ? 183.88100 321.79900 14.18400  1.000 60.70542  ? 150 SER F CB  1 
ATOM   654  O OG  . SER A 1 115 ? 184.37300 321.53500 15.49600  1.000 61.82091  ? 150 SER F OG  1 
ATOM   655  N N   . GLY A 1 116 ? 183.86000 321.87300 11.00900  1.000 65.36001  ? 151 GLY F N   1 
ATOM   656  C CA  . GLY A 1 116 ? 183.33900 321.39700 9.74400   1.000 61.20555  ? 151 GLY F CA  1 
ATOM   657  C C   . GLY A 1 116 ? 184.38100 321.22400 8.65200   1.000 64.29229  ? 151 GLY F C   1 
ATOM   658  O O   . GLY A 1 116 ? 184.28700 320.26500 7.88200   1.000 67.64903  ? 151 GLY F O   1 
ATOM   659  N N   . VAL A 1 117 ? 185.40900 322.08000 8.59200   1.000 61.56318  ? 152 VAL F N   1 
ATOM   660  C CA  . VAL A 1 117 ? 186.43300 321.88800 7.56100   1.000 62.74600  ? 152 VAL F CA  1 
ATOM   661  C C   . VAL A 1 117 ? 187.12900 320.54400 7.76500   1.000 70.14203  ? 152 VAL F C   1 
ATOM   662  O O   . VAL A 1 117 ? 187.56300 319.90700 6.79700   1.000 73.31666  ? 152 VAL F O   1 
ATOM   663  C CB  . VAL A 1 117 ? 187.44500 323.05100 7.53400   1.000 61.23750  ? 152 VAL F CB  1 
ATOM   664  C CG1 . VAL A 1 117 ? 188.66700 322.65700 6.73400   1.000 60.35194  ? 152 VAL F CG1 1 
ATOM   665  C CG2 . VAL A 1 117 ? 186.81400 324.29600 6.93000   1.000 62.61613  ? 152 VAL F CG2 1 
ATOM   666  N N   . ALA A 1 118 ? 187.28400 320.10900 9.02400   1.000 71.29061  ? 153 ALA F N   1 
ATOM   667  C CA  . ALA A 1 118 ? 187.89000 318.80500 9.27600   1.000 73.08819  ? 153 ALA F CA  1 
ATOM   668  C C   . ALA A 1 118 ? 187.06100 317.66000 8.70200   1.000 72.67407  ? 153 ALA F C   1 
ATOM   669  O O   . ALA A 1 118 ? 187.62600 316.64100 8.28100   1.000 75.32011  ? 153 ALA F O   1 
ATOM   670  C CB  . ALA A 1 118 ? 188.07100 318.58900 10.78300  1.000 63.82038  ? 153 ALA F CB  1 
ATOM   671  N N   . VAL A 1 119 ? 185.73800 317.81400 8.62100   1.000 69.51798  ? 154 VAL F N   1 
ATOM   672  C CA  . VAL A 1 119 ? 184.95200 316.72400 8.05600   1.000 68.56705  ? 154 VAL F CA  1 
ATOM   673  C C   . VAL A 1 119 ? 185.11100 316.70800 6.54000   1.000 75.05437  ? 154 VAL F C   1 
ATOM   674  O O   . VAL A 1 119 ? 185.12000 315.64300 5.91600   1.000 80.94207  ? 154 VAL F O   1 
ATOM   675  C CB  . VAL A 1 119 ? 183.48300 316.80000 8.49400   1.000 65.04976  ? 154 VAL F CB  1 
ATOM   676  C CG1 . VAL A 1 119 ? 182.72800 315.58900 7.98200   1.000 69.38457  ? 154 VAL F CG1 1 
ATOM   677  C CG2 . VAL A 1 119 ? 183.38200 316.86400 10.01200  1.000 57.22615  ? 154 VAL F CG2 1 
ATOM   678  N N   . CYS A 1 120 ? 185.20200 317.89200 5.92000   1.000 70.79982  ? 155 CYS F N   1 
ATOM   679  C CA  . CYS A 1 120 ? 185.40200 317.97100 4.47700   1.000 76.30494  ? 155 CYS F CA  1 
ATOM   680  C C   . CYS A 1 120 ? 186.75200 317.42900 4.06000   1.000 78.32248  ? 155 CYS F C   1 
ATOM   681  O O   . CYS A 1 120 ? 186.89100 316.86700 2.96400   1.000 86.00865  ? 155 CYS F O   1 
ATOM   682  C CB  . CYS A 1 120 ? 185.29900 319.42300 3.99000   1.000 78.16280  ? 155 CYS F CB  1 
ATOM   683  S SG  . CYS A 1 120 ? 183.61400 320.12800 3.92200   1.000 103.80557 ? 155 CYS F SG  1 
ATOM   684  N N   . LYS A 1 121 ? 187.76700 317.60800 4.89800   1.000 79.78660  ? 156 LYS F N   1 
ATOM   685  C CA  . LYS A 1 121 ? 189.06400 317.09400 4.49600   1.000 80.80333  ? 156 LYS F CA  1 
ATOM   686  C C   . LYS A 1 121 ? 189.11100 315.56500 4.50600   1.000 80.25138  ? 156 LYS F C   1 
ATOM   687  O O   . LYS A 1 121 ? 189.82400 314.97000 3.69600   1.000 81.48132  ? 156 LYS F O   1 
ATOM   688  C CB  . LYS A 1 121 ? 190.12700 317.69800 5.40200   1.000 80.94856  ? 156 LYS F CB  1 
ATOM   689  C CG  . LYS A 1 121 ? 190.65800 319.05900 4.89500   1.000 80.58743  ? 156 LYS F CG  1 
ATOM   690  C CD  . LYS A 1 121 ? 190.62000 319.19400 3.36900   1.000 81.11096  ? 156 LYS F CD  1 
ATOM   691  C CE  . LYS A 1 121 ? 189.18900 319.53500 2.88700   1.000 80.11073  ? 156 LYS F CE  1 
ATOM   692  N NZ  . LYS A 1 121 ? 189.02400 319.47300 1.40900   1.000 86.26881  ? 156 LYS F NZ  1 
ATOM   693  N N   . VAL A 1 122 ? 188.34200 314.91800 5.38500   1.000 79.48917  ? 157 VAL F N   1 
ATOM   694  C CA  . VAL A 1 122 ? 188.25500 313.45400 5.43700   1.000 80.56762  ? 157 VAL F CA  1 
ATOM   695  C C   . VAL A 1 122 ? 187.48100 312.91700 4.24100   1.000 87.53380  ? 157 VAL F C   1 
ATOM   696  O O   . VAL A 1 122 ? 187.78100 311.83900 3.70700   1.000 90.46801  ? 157 VAL F O   1 
ATOM   697  C CB  . VAL A 1 122 ? 187.64300 312.97700 6.76500   1.000 80.03171  ? 157 VAL F CB  1 
ATOM   698  C CG1 . VAL A 1 122 ? 187.53100 311.44500 6.78300   1.000 91.58228  ? 157 VAL F CG1 1 
ATOM   699  C CG2 . VAL A 1 122 ? 188.49900 313.45900 7.92900   1.000 82.99775  ? 157 VAL F CG2 1 
ATOM   700  N N   . LEU A 1 123 ? 186.44000 313.64300 3.83700   1.000 89.16323  ? 158 LEU F N   1 
ATOM   701  C CA  . LEU A 1 123 ? 185.59700 313.22400 2.73300   1.000 86.28412  ? 158 LEU F CA  1 
ATOM   702  C C   . LEU A 1 123 ? 186.39000 313.21200 1.43300   1.000 86.39272  ? 158 LEU F C   1 
ATOM   703  O O   . LEU A 1 123 ? 186.11200 312.39100 0.55000   1.000 93.61136  ? 158 LEU F O   1 
ATOM   704  C CB  . LEU A 1 123 ? 184.39700 314.17300 2.66300   1.000 81.65566  ? 158 LEU F CB  1 
ATOM   705  C CG  . LEU A 1 123 ? 183.22100 313.65100 3.49900   1.000 77.28911  ? 158 LEU F CG  1 
ATOM   706  C CD1 . LEU A 1 123 ? 181.99300 314.52000 3.35000   1.000 75.75679  ? 158 LEU F CD1 1 
ATOM   707  C CD2 . LEU A 1 123 ? 182.90900 312.16900 3.24300   1.000 92.13123  ? 158 LEU F CD2 1 
ATOM   708  N N   . HIS A 1 124 ? 187.40700 314.06900 1.31300   1.000 78.65897  ? 159 HIS F N   1 
ATOM   709  C CA  . HIS A 1 124 ? 188.22300 314.05500 0.10800   1.000 86.21654  ? 159 HIS F CA  1 
ATOM   710  C C   . HIS A 1 124 ? 189.10500 312.80500 0.00900   1.000 94.39207  ? 159 HIS F C   1 
ATOM   711  O O   . HIS A 1 124 ? 189.66100 312.53600 -1.06500  1.000 90.20462  ? 159 HIS F O   1 
ATOM   712  C CB  . HIS A 1 124 ? 189.11200 315.28800 0.10400   1.000 78.50642  ? 159 HIS F CB  1 
ATOM   713  C CG  . HIS A 1 124 ? 188.45400 316.49800 -0.45800  1.000 80.20161  ? 159 HIS F CG  1 
ATOM   714  N ND1 . HIS A 1 124 ? 188.96700 317.18800 -1.53500  1.000 86.45057  ? 159 HIS F ND1 1 
ATOM   715  C CD2 . HIS A 1 124 ? 187.31500 317.13600 -0.10600  1.000 79.74019  ? 159 HIS F CD2 1 
ATOM   716  C CE1 . HIS A 1 124 ? 188.17900 318.21200 -1.81500  1.000 81.32463  ? 159 HIS F CE1 1 
ATOM   717  N NE2 . HIS A 1 124 ? 187.16900 318.20000 -0.96500  1.000 83.39730  ? 159 HIS F NE2 1 
ATOM   718  N N   . LEU A 1 125 ? 189.24700 312.04500 1.09800   1.000 95.45248  ? 160 LEU F N   1 
ATOM   719  C CA  . LEU A 1 125 ? 189.98600 310.78900 1.08600   1.000 90.19671  ? 160 LEU F CA  1 
ATOM   720  C C   . LEU A 1 125 ? 189.24600 309.73100 0.27800   1.000 95.75067  ? 160 LEU F C   1 
ATOM   721  O O   . LEU A 1 125 ? 188.01100 309.67300 0.27300   1.000 96.11145  ? 160 LEU F O   1 
ATOM   722  C CB  . LEU A 1 125 ? 190.22300 310.28400 2.51100   1.000 91.77634  ? 160 LEU F CB  1 
ATOM   723  C CG  . LEU A 1 125 ? 190.99200 311.28300 3.38200   1.000 87.95644  ? 160 LEU F CG  1 
ATOM   724  C CD1 . LEU A 1 125 ? 191.24100 310.72800 4.79000   1.000 80.49485  ? 160 LEU F CD1 1 
ATOM   725  C CD2 . LEU A 1 125 ? 192.27700 311.76500 2.69500   1.000 88.40896  ? 160 LEU F CD2 1 
ATOM   726  N N   . GLU A 1 126 ? 190.01500 308.81400 -0.30800  1.000 96.77964  ? 161 GLU F N   1 
ATOM   727  C CA  . GLU A 1 126 ? 189.43300 307.76300 -1.13400  1.000 91.91456  ? 161 GLU F CA  1 
ATOM   728  C C   . GLU A 1 126 ? 188.69500 306.77300 -0.25500  1.000 96.06654  ? 161 GLU F C   1 
ATOM   729  O O   . GLU A 1 126 ? 189.23800 306.26600 0.73200   1.000 96.77586  ? 161 GLU F O   1 
ATOM   730  C CB  . GLU A 1 126 ? 190.51900 307.02700 -1.90400  1.000 93.53839  ? 161 GLU F CB  1 
ATOM   731  C CG  . GLU A 1 126 ? 191.18200 307.68000 -3.10900  1.000 99.57364  ? 161 GLU F CG  1 
ATOM   732  C CD  . GLU A 1 126 ? 192.18000 308.76800 -2.73800  1.000 105.07795 ? 161 GLU F CD  1 
ATOM   733  O OE1 . GLU A 1 126 ? 192.16800 309.22600 -1.56900  1.000 102.45241 ? 161 GLU F OE1 1 
ATOM   734  O OE2 . GLU A 1 126 ? 193.12000 308.99500 -3.54000  1.000 103.03635 ? 161 GLU F OE2 1 
ATOM   735  N N   . GLY A 1 127 ? 187.44000 306.53000 -0.59700  1.000 96.50668  ? 162 GLY F N   1 
ATOM   736  C CA  . GLY A 1 127 ? 186.62200 305.60900 0.14300   1.000 96.20621  ? 162 GLY F CA  1 
ATOM   737  C C   . GLY A 1 127 ? 185.74500 306.26500 1.17500   1.000 103.55951 ? 162 GLY F C   1 
ATOM   738  O O   . GLY A 1 127 ? 184.82200 305.61300 1.68600   1.000 100.70203 ? 162 GLY F O   1 
ATOM   739  N N   . GLU A 1 128 ? 185.98500 307.53800 1.49200   1.000 103.80354 ? 163 GLU F N   1 
ATOM   740  C CA  . GLU A 1 128 ? 185.15900 308.11100 2.53800   1.000 103.38734 ? 163 GLU F CA  1 
ATOM   741  C C   . GLU A 1 128 ? 183.80400 308.55600 2.00100   1.000 99.52137  ? 163 GLU F C   1 
ATOM   742  O O   . GLU A 1 128 ? 182.77000 308.27600 2.62400   1.000 97.08737  ? 163 GLU F O   1 
ATOM   743  C CB  . GLU A 1 128 ? 185.91000 309.28800 3.17600   1.000 101.92659 ? 163 GLU F CB  1 
ATOM   744  C CG  . GLU A 1 128 ? 186.79900 308.89700 4.35500   1.000 95.60978  ? 163 GLU F CG  1 
ATOM   745  C CD  . GLU A 1 128 ? 185.99200 308.38100 5.53000   1.000 98.90602  ? 163 GLU F CD  1 
ATOM   746  O OE1 . GLU A 1 128 ? 184.99500 309.04400 5.88600   1.000 99.99301  ? 163 GLU F OE1 1 
ATOM   747  O OE2 . GLU A 1 128 ? 186.34600 307.32200 6.09700   1.000 102.66726 ? 163 GLU F OE2 1 
ATOM   748  N N   . VAL A 1 129 ? 183.77100 309.16600 0.81200   1.000 93.88103  ? 164 VAL F N   1 
ATOM   749  C CA  . VAL A 1 129 ? 182.47400 309.48200 0.23000   1.000 94.85098  ? 164 VAL F CA  1 
ATOM   750  C C   . VAL A 1 129 ? 181.71800 308.21400 -0.13800  1.000 96.23758  ? 164 VAL F C   1 
ATOM   751  O O   . VAL A 1 129 ? 180.48000 308.17300 -0.06000  1.000 88.28548  ? 164 VAL F O   1 
ATOM   752  C CB  . VAL A 1 129 ? 182.68000 310.40800 -0.98900  1.000 94.31286  ? 164 VAL F CB  1 
ATOM   753  C CG1 . VAL A 1 129 ? 183.06000 311.80400 -0.51900  1.000 90.85463  ? 164 VAL F CG1 1 
ATOM   754  C CG2 . VAL A 1 129 ? 183.77100 309.85400 -1.89900  1.000 95.46886  ? 164 VAL F CG2 1 
ATOM   755  N N   . ASN A 1 130 ? 182.45800 307.14000 -0.45000  1.000 100.75233 ? 165 ASN F N   1 
ATOM   756  C CA  . ASN A 1 130 ? 181.88000 305.83700 -0.76200  1.000 96.26394  ? 165 ASN F CA  1 
ATOM   757  C C   . ASN A 1 130 ? 181.22100 305.20700 0.45400   1.000 96.42317  ? 165 ASN F C   1 
ATOM   758  O O   . ASN A 1 130 ? 180.26500 304.43300 0.31100   1.000 86.75369  ? 165 ASN F O   1 
ATOM   759  C CB  . ASN A 1 130 ? 182.98300 304.92300 -1.27800  1.000 98.61138  ? 165 ASN F CB  1 
ATOM   760  C CG  . ASN A 1 130 ? 183.74300 305.53600 -2.43700  1.000 102.27679 ? 165 ASN F CG  1 
ATOM   761  O OD1 . ASN A 1 130 ? 183.23100 305.59000 -3.55000  1.000 104.02099 ? 165 ASN F OD1 1 
ATOM   762  N ND2 . ASN A 1 130 ? 184.94500 306.05000 -2.17300  1.000 96.72814  ? 165 ASN F ND2 1 
ATOM   763  N N   . LYS A 1 131 ? 181.67600 305.55100 1.66100   1.000 97.07062  ? 166 LYS F N   1 
ATOM   764  C CA  . LYS A 1 131 ? 181.04800 304.94400 2.82800   1.000 96.42085  ? 166 LYS F CA  1 
ATOM   765  C C   . LYS A 1 131 ? 179.67600 305.53400 3.04200   1.000 98.31311  ? 166 LYS F C   1 
ATOM   766  O O   . LYS A 1 131 ? 178.72000 304.80100 3.29300   1.000 99.58270  ? 166 LYS F O   1 
ATOM   767  C CB  . LYS A 1 131 ? 181.77000 305.17600 4.14200   1.000 96.44138  ? 166 LYS F CB  1 
ATOM   768  C CG  . LYS A 1 131 ? 181.65000 304.00800 5.03100   1.000 94.80687  ? 166 LYS F CG  1 
ATOM   769  C CD  . LYS A 1 131 ? 182.22700 304.32000 6.38300   1.000 101.06898 ? 166 LYS F CD  1 
ATOM   770  C CE  . LYS A 1 131 ? 183.68600 304.73500 6.46500   1.000 100.90999 ? 166 LYS F CE  1 
ATOM   771  N NZ  . LYS A 1 131 ? 183.93100 304.93000 7.94000   1.000 97.38943  ? 166 LYS F NZ  1 
ATOM   772  N N   . ILE A 1 132 ? 179.58200 306.87100 3.08300   1.000 97.61569  ? 167 ILE F N   1 
ATOM   773  C CA  . ILE A 1 132 ? 178.28300 307.51800 3.26900   1.000 96.12720  ? 167 ILE F CA  1 
ATOM   774  C C   . ILE A 1 132 ? 177.34600 307.18200 2.11400   1.000 95.86254  ? 167 ILE F C   1 
ATOM   775  O O   . ILE A 1 132 ? 176.12600 307.06000 2.31000   1.000 93.38104  ? 167 ILE F O   1 
ATOM   776  C CB  . ILE A 1 132 ? 178.49500 309.04500 3.42400   1.000 95.73751  ? 167 ILE F CB  1 
ATOM   777  C CG1 . ILE A 1 132 ? 179.38800 309.57200 2.28600   1.000 93.89205  ? 167 ILE F CG1 1 
ATOM   778  C CG2 . ILE A 1 132 ? 179.08300 309.39000 4.78600   1.000 92.13250  ? 167 ILE F CG2 1 
ATOM   779  C CD1 . ILE A 1 132 ? 179.73000 311.04600 2.41900   1.000 84.65337  ? 167 ILE F CD1 1 
ATOM   780  N N   . LYS A 1 133 ? 177.89200 306.96000 0.90900   1.000 96.89478  ? 168 LYS F N   1 
ATOM   781  C CA  . LYS A 1 133 ? 177.02600 306.55700 -0.19800  1.000 93.36575  ? 168 LYS F CA  1 
ATOM   782  C C   . LYS A 1 133 ? 176.43800 305.18000 0.05100   1.000 94.53657  ? 168 LYS F C   1 
ATOM   783  O O   . LYS A 1 133 ? 175.31400 304.89800 -0.38300  1.000 95.24940  ? 168 LYS F O   1 
ATOM   784  C CB  . LYS A 1 133 ? 177.77500 306.51900 -1.53400  1.000 87.51916  ? 168 LYS F CB  1 
ATOM   785  C CG  . LYS A 1 133 ? 176.81200 306.43800 -2.73500  1.000 86.00162  ? 168 LYS F CG  1 
ATOM   786  C CD  . LYS A 1 133 ? 177.49800 306.48600 -4.11000  1.000 83.53139  ? 168 LYS F CD  1 
ATOM   787  C CE  . LYS A 1 133 ? 178.70200 307.41500 -4.15000  1.000 80.69528  ? 168 LYS F CE  1 
ATOM   788  N NZ  . LYS A 1 133 ? 179.36000 307.42100 -5.48300  1.000 70.67786  ? 168 LYS F NZ  1 
ATOM   789  N N   . SER A 1 134 ? 177.14400 304.35300 0.82800   1.000 92.03200  ? 169 SER F N   1 
ATOM   790  C CA  . SER A 1 134 ? 176.66000 303.02100 1.14900   1.000 92.81574  ? 169 SER F CA  1 
ATOM   791  C C   . SER A 1 134 ? 175.70200 303.04100 2.32800   1.000 94.08718  ? 169 SER F C   1 
ATOM   792  O O   . SER A 1 134 ? 174.70300 302.31300 2.32500   1.000 96.35876  ? 169 SER F O   1 
ATOM   793  C CB  . SER A 1 134 ? 177.84600 302.10200 1.44200   1.000 94.89648  ? 169 SER F CB  1 
ATOM   794  O OG  . SER A 1 134 ? 177.57800 300.77300 1.03100   1.000 94.38843  ? 169 SER F OG  1 
ATOM   795  N N   . ALA A 1 135 ? 175.96800 303.87300 3.33500   1.000 92.60811  ? 170 ALA F N   1 
ATOM   796  C CA  . ALA A 1 135 ? 175.07200 303.88000 4.48300   1.000 95.23185  ? 170 ALA F CA  1 
ATOM   797  C C   . ALA A 1 135 ? 173.70400 304.45100 4.11500   1.000 96.48410  ? 170 ALA F C   1 
ATOM   798  O O   . ALA A 1 135 ? 172.67300 303.98800 4.62500   1.000 91.02467  ? 170 ALA F O   1 
ATOM   799  C CB  . ALA A 1 135 ? 175.70500 304.66500 5.62800   1.000 93.63597  ? 170 ALA F CB  1 
ATOM   800  N N   . LEU A 1 136 ? 173.66300 305.46300 3.23300   1.000 94.62929  ? 171 LEU F N   1 
ATOM   801  C CA  . LEU A 1 136 ? 172.39000 306.02500 2.79100   1.000 93.12560  ? 171 LEU F CA  1 
ATOM   802  C C   . LEU A 1 136 ? 171.87400 305.37400 1.50700   1.000 94.42083  ? 171 LEU F C   1 
ATOM   803  O O   . LEU A 1 136 ? 171.19800 306.04100 0.70900   1.000 88.80517  ? 171 LEU F O   1 
ATOM   804  C CB  . LEU A 1 136 ? 172.52400 307.53600 2.59200   1.000 95.24441  ? 171 LEU F CB  1 
ATOM   805  C CG  . LEU A 1 136 ? 172.85300 308.46700 3.77200   1.000 93.69772  ? 171 LEU F CG  1 
ATOM   806  C CD1 . LEU A 1 136 ? 171.94800 308.25500 5.00500   1.000 83.10634  ? 171 LEU F CD1 1 
ATOM   807  C CD2 . LEU A 1 136 ? 174.34900 308.37200 4.12600   1.000 91.66999  ? 171 LEU F CD2 1 
ATOM   808  N N   . LEU A 1 137 ? 172.12900 304.07500 1.31000   1.000 97.48524  ? 172 LEU F N   1 
ATOM   809  C CA  . LEU A 1 137 ? 171.66700 303.38200 0.11000   1.000 94.27238  ? 172 LEU F CA  1 
ATOM   810  C C   . LEU A 1 137 ? 170.20700 302.98300 0.24400   1.000 92.49093  ? 172 LEU F C   1 
ATOM   811  O O   . LEU A 1 137 ? 169.47000 302.97900 -0.74700  1.000 93.05193  ? 172 LEU F O   1 
ATOM   812  C CB  . LEU A 1 137 ? 172.54900 302.17400 -0.21400  1.000 97.28485  ? 172 LEU F CB  1 
ATOM   813  C CG  . LEU A 1 137 ? 173.63600 302.46600 -1.26900  1.000 93.08515  ? 172 LEU F CG  1 
ATOM   814  C CD1 . LEU A 1 137 ? 174.32600 301.19000 -1.74200  1.000 84.01476  ? 172 LEU F CD1 1 
ATOM   815  C CD2 . LEU A 1 137 ? 173.10200 303.26800 -2.46200  1.000 83.06576  ? 172 LEU F CD2 1 
ATOM   816  N N   . SER A 1 138 ? 169.77100 302.70900 1.46600   1.000 90.31804  ? 173 SER F N   1 
ATOM   817  C CA  . SER A 1 138 ? 168.43200 302.22600 1.72900   1.000 89.22096  ? 173 SER F CA  1 
ATOM   818  C C   . SER A 1 138 ? 167.64400 303.19900 2.57900   1.000 94.45434  ? 173 SER F C   1 
ATOM   819  O O   . SER A 1 138 ? 166.40800 303.14300 2.55900   1.000 92.14930  ? 173 SER F O   1 
ATOM   820  C CB  . SER A 1 138 ? 168.48300 300.86300 2.43300   1.000 91.82569  ? 173 SER F CB  1 
ATOM   821  O OG  . SER A 1 138 ? 169.61400 300.80600 3.28800   1.000 100.70415 ? 173 SER F OG  1 
ATOM   822  N N   . THR A 1 139 ? 168.31200 304.04500 3.36900   1.000 102.80770 ? 174 THR F N   1 
ATOM   823  C CA  . THR A 1 139 ? 167.61600 304.97600 4.24100   1.000 98.20158  ? 174 THR F CA  1 
ATOM   824  C C   . THR A 1 139 ? 168.11200 306.39100 3.93000   1.000 90.51111  ? 174 THR F C   1 
ATOM   825  O O   . THR A 1 139 ? 169.16500 306.57600 3.30100   1.000 86.20594  ? 174 THR F O   1 
ATOM   826  C CB  . THR A 1 139 ? 167.88900 304.62900 5.71000   1.000 95.32988  ? 174 THR F CB  1 
ATOM   827  O OG1 . THR A 1 139 ? 169.30800 304.62000 5.92700   1.000 92.49353  ? 174 THR F OG1 1 
ATOM   828  C CG2 . THR A 1 139 ? 167.33800 303.23700 6.03700   1.000 93.82477  ? 174 THR F CG2 1 
ATOM   829  N N   . ASN A 1 140 ? 167.35800 307.39900 4.39700   1.000 89.62474  ? 175 ASN F N   1 
ATOM   830  C CA  . ASN A 1 140 ? 167.78400 308.79300 4.24300   1.000 92.48892  ? 175 ASN F CA  1 
ATOM   831  C C   . ASN A 1 140 ? 168.75500 309.24300 5.32400   1.000 92.62928  ? 175 ASN F C   1 
ATOM   832  O O   . ASN A 1 140 ? 169.71700 309.96600 5.03400   1.000 90.29943  ? 175 ASN F O   1 
ATOM   833  C CB  . ASN A 1 140 ? 166.59700 309.74600 4.12900   1.000 88.89673  ? 175 ASN F CB  1 
ATOM   834  C CG  . ASN A 1 140 ? 165.74700 309.45000 2.92000   1.000 85.83039  ? 175 ASN F CG  1 
ATOM   835  O OD1 . ASN A 1 140 ? 166.25200 308.95600 1.90000   1.000 81.94593  ? 175 ASN F OD1 1 
ATOM   836  N ND2 . ASN A 1 140 ? 164.46900 309.79900 2.99400   1.000 86.08387  ? 175 ASN F ND2 1 
ATOM   837  N N   . LYS A 1 141 ? 168.53400 308.81800 6.56600   1.000 94.20113  ? 176 LYS F N   1 
ATOM   838  C CA  . LYS A 1 141 ? 169.39300 309.23000 7.65800   1.000 90.42509  ? 176 LYS F CA  1 
ATOM   839  C C   . LYS A 1 141 ? 170.15800 308.02400 8.17100   1.000 90.30908  ? 176 LYS F C   1 
ATOM   840  O O   . LYS A 1 141 ? 169.65100 306.89900 8.18400   1.000 89.94724  ? 176 LYS F O   1 
ATOM   841  C CB  . LYS A 1 141 ? 168.57500 309.82000 8.81400   1.000 88.32513  ? 176 LYS F CB  1 
ATOM   842  C CG  . LYS A 1 141 ? 167.70000 311.01400 8.46500   1.000 90.17271  ? 176 LYS F CG  1 
ATOM   843  C CD  . LYS A 1 141 ? 166.49100 311.01300 9.38600   1.000 92.12516  ? 176 LYS F CD  1 
ATOM   844  C CE  . LYS A 1 141 ? 166.67700 309.98000 10.50600  1.000 89.18690  ? 176 LYS F CE  1 
ATOM   845  N NZ  . LYS A 1 141 ? 165.49100 309.87700 11.41300  1.000 87.82564  ? 176 LYS F NZ  1 
ATOM   846  N N   . ALA A 1 142 ? 171.38300 308.27800 8.61200   1.000 94.45935  ? 177 ALA F N   1 
ATOM   847  C CA  . ALA A 1 142 ? 172.21700 307.21500 9.13900   1.000 86.67252  ? 177 ALA F CA  1 
ATOM   848  C C   . ALA A 1 142 ? 173.44600 307.82700 9.78500   1.000 90.65688  ? 177 ALA F C   1 
ATOM   849  O O   . ALA A 1 142 ? 174.00800 308.80000 9.26400   1.000 89.13459  ? 177 ALA F O   1 
ATOM   850  C CB  . ALA A 1 142 ? 172.63400 306.23700 8.03400   1.000 88.78967  ? 177 ALA F CB  1 
ATOM   851  N N   . VAL A 1 143 ? 173.87100 307.24000 10.89000  1.000 89.12737  ? 178 VAL F N   1 
ATOM   852  C CA  . VAL A 1 143 ? 175.10800 307.65500 11.52900  1.000 86.43985  ? 178 VAL F CA  1 
ATOM   853  C C   . VAL A 1 143 ? 176.20900 306.89100 10.81700  1.000 83.64198  ? 178 VAL F C   1 
ATOM   854  O O   . VAL A 1 143 ? 176.06900 305.69700 10.54200  1.000 89.95660  ? 178 VAL F O   1 
ATOM   855  C CB  . VAL A 1 143 ? 175.09200 307.37000 13.04100  1.000 83.79286  ? 178 VAL F CB  1 
ATOM   856  C CG1 . VAL A 1 143 ? 176.26100 308.07000 13.71200  1.000 81.68709  ? 178 VAL F CG1 1 
ATOM   857  C CG2 . VAL A 1 143 ? 173.76800 307.80900 13.66100  1.000 71.25513  ? 178 VAL F CG2 1 
ATOM   858  N N   . VAL A 1 144 ? 177.29800 307.56200 10.49000  1.000 81.96329  ? 179 VAL F N   1 
ATOM   859  C CA  . VAL A 1 144 ? 178.37100 306.92600 9.74400   1.000 88.27986  ? 179 VAL F CA  1 
ATOM   860  C C   . VAL A 1 144 ? 179.65800 307.18900 10.49500  1.000 93.07813  ? 179 VAL F C   1 
ATOM   861  O O   . VAL A 1 144 ? 180.00400 308.34900 10.74400  1.000 91.45167  ? 179 VAL F O   1 
ATOM   862  C CB  . VAL A 1 144 ? 178.45200 307.49200 8.31200   1.000 84.17410  ? 179 VAL F CB  1 
ATOM   863  C CG1 . VAL A 1 144 ? 179.59800 306.86800 7.53500   1.000 91.23086  ? 179 VAL F CG1 1 
ATOM   864  C CG2 . VAL A 1 144 ? 177.12000 307.30900 7.59500   1.000 86.94848  ? 179 VAL F CG2 1 
ATOM   865  N N   . SER A 1 145 ? 180.39600 306.11900 10.80700  1.000 96.65820  ? 180 SER F N   1 
ATOM   866  C CA  . SER A 1 145 ? 181.69700 306.27300 11.43900  1.000 92.97510  ? 180 SER F CA  1 
ATOM   867  C C   . SER A 1 145 ? 182.75800 306.36100 10.35500  1.000 96.95961  ? 180 SER F C   1 
ATOM   868  O O   . SER A 1 145 ? 183.13500 305.36200 9.73500   1.000 103.90634 ? 180 SER F O   1 
ATOM   869  C CB  . SER A 1 145 ? 181.96800 305.11200 12.39000  1.000 96.33582  ? 180 SER F CB  1 
ATOM   870  O OG  . SER A 1 145 ? 181.01100 305.08000 13.43500  1.000 100.80899 ? 180 SER F OG  1 
ATOM   871  N N   . LEU A 1 146 ? 183.27100 307.56300 10.21100  1.000 94.09536  ? 181 LEU F N   1 
ATOM   872  C CA  . LEU A 1 146 ? 184.25700 308.11700 9.30900   1.000 94.37857  ? 181 LEU F CA  1 
ATOM   873  C C   . LEU A 1 146 ? 185.66300 307.76400 9.75300   1.000 99.71803  ? 181 LEU F C   1 
ATOM   874  O O   . LEU A 1 146 ? 185.88600 307.00500 10.70200  1.000 99.13526  ? 181 LEU F O   1 
ATOM   875  C CB  . LEU A 1 146 ? 184.08400 309.62800 9.23200   1.000 93.82254  ? 181 LEU F CB  1 
ATOM   876  C CG  . LEU A 1 146 ? 182.60700 310.01900 9.20700   1.000 94.97658  ? 181 LEU F CG  1 
ATOM   877  C CD1 . LEU A 1 146 ? 182.43900 311.47200 8.81000   1.000 86.57418  ? 181 LEU F CD1 1 
ATOM   878  C CD2 . LEU A 1 146 ? 181.82500 309.09800 8.25400   1.000 93.65184  ? 181 LEU F CD2 1 
ATOM   879  N N   . SER A 1 147 ? 186.62800 308.25600 8.99000   1.000 104.45830 ? 182 SER F N   1 
ATOM   880  C CA  . SER A 1 147 ? 187.97000 308.01000 9.44700   1.000 101.99737 ? 182 SER F CA  1 
ATOM   881  C C   . SER A 1 147 ? 188.11700 309.12200 10.47600  1.000 103.33932 ? 182 SER F C   1 
ATOM   882  O O   . SER A 1 147 ? 187.30500 310.05300 10.51100  1.000 106.34220 ? 182 SER F O   1 
ATOM   883  C CB  . SER A 1 147 ? 188.99000 308.12000 8.30900   1.000 95.33501  ? 182 SER F CB  1 
ATOM   884  O OG  . SER A 1 147 ? 190.29700 308.40300 8.79800   1.000 98.37284  ? 182 SER F OG  1 
ATOM   885  N N   . ASN A 1 148 ? 189.06200 309.01300 11.37700  1.000 99.78371  ? 183 ASN F N   1 
ATOM   886  C CA  . ASN A 1 148 ? 189.19400 310.05000 12.38600  1.000 100.55890 ? 183 ASN F CA  1 
ATOM   887  C C   . ASN A 1 148 ? 188.20400 309.62400 13.46100  1.000 102.94418 ? 183 ASN F C   1 
ATOM   888  O O   . ASN A 1 148 ? 187.80400 310.48500 14.27500  1.000 102.71742 ? 183 ASN F O   1 
ATOM   889  C CB  . ASN A 1 148 ? 188.84500 311.48800 11.97200  1.000 94.82722  ? 183 ASN F CB  1 
ATOM   890  C CG  . ASN A 1 148 ? 189.86900 312.11500 11.07600  1.000 100.34701 ? 183 ASN F CG  1 
ATOM   891  O OD1 . ASN A 1 148 ? 190.81500 311.45700 10.62600  1.000 97.98132  ? 183 ASN F OD1 1 
ATOM   892  N ND2 . ASN A 1 148 ? 189.67200 313.39800 10.77600  1.000 91.20171  ? 183 ASN F ND2 1 
ATOM   893  N N   . GLY A 1 149 ? 187.68500 308.37000 13.40900  1.000 100.05336 ? 184 GLY F N   1 
ATOM   894  C CA  . GLY A 1 149 ? 186.83000 307.93300 14.50000  1.000 98.95355  ? 184 GLY F CA  1 
ATOM   895  C C   . GLY A 1 149 ? 185.59500 308.75900 14.80100  1.000 98.86321  ? 184 GLY F C   1 
ATOM   896  O O   . GLY A 1 149 ? 185.12400 308.72000 15.94300  1.000 100.26313 ? 184 GLY F O   1 
ATOM   897  N N   . VAL A 1 150 ? 185.13800 309.59900 13.87800  1.000 101.86408 ? 185 VAL F N   1 
ATOM   898  C CA  . VAL A 1 150 ? 184.03300 310.52200 14.12300  1.000 95.46968  ? 185 VAL F CA  1 
ATOM   899  C C   . VAL A 1 150 ? 182.71800 309.90500 13.66200  1.000 93.63519  ? 185 VAL F C   1 
ATOM   900  O O   . VAL A 1 150 ? 182.54600 309.56800 12.48400  1.000 93.54964  ? 185 VAL F O   1 
ATOM   901  C CB  . VAL A 1 150 ? 184.28500 311.85300 13.38700  1.000 90.93541  ? 185 VAL F CB  1 
ATOM   902  C CG1 . VAL A 1 150 ? 185.32000 312.69600 14.11500  1.000 81.48164  ? 185 VAL F CG1 1 
ATOM   903  C CG2 . VAL A 1 150 ? 184.76000 311.58500 11.95100  1.000 92.78025  ? 185 VAL F CG2 1 
ATOM   904  N N   . SER A 1 151 ? 181.79600 309.72800 14.62400  1.000 91.80950  ? 186 SER F N   1 
ATOM   905  C CA  . SER A 1 151 ? 180.44600 309.22200 14.35500  1.000 90.46107  ? 186 SER F CA  1 
ATOM   906  C C   . SER A 1 151 ? 179.51400 310.38800 14.05900  1.000 95.84174  ? 186 SER F C   1 
ATOM   907  O O   . SER A 1 151 ? 178.82000 310.91100 14.93500  1.000 93.90519  ? 186 SER F O   1 
ATOM   908  C CB  . SER A 1 151 ? 179.92100 308.40200 15.52600  1.000 86.07488  ? 186 SER F CB  1 
ATOM   909  O OG  . SER A 1 151 ? 180.35900 307.05800 15.45700  1.000 92.51125  ? 186 SER F OG  1 
ATOM   910  N N   . VAL A 1 152 ? 179.50300 310.77900 12.78200  1.000 95.78710  ? 187 VAL F N   1 
ATOM   911  C CA  . VAL A 1 152 ? 178.77600 311.94200 12.30500  1.000 83.98984  ? 187 VAL F CA  1 
ATOM   912  C C   . VAL A 1 152 ? 177.41900 311.46800 11.81100  1.000 80.95544  ? 187 VAL F C   1 
ATOM   913  O O   . VAL A 1 152 ? 177.23500 310.30200 11.45600  1.000 84.74334  ? 187 VAL F O   1 
ATOM   914  C CB  . VAL A 1 152 ? 179.55200 312.66200 11.19000  1.000 75.99211  ? 187 VAL F CB  1 
ATOM   915  C CG1 . VAL A 1 152 ? 179.30700 311.98100 9.85500   1.000 76.16967  ? 187 VAL F CG1 1 
ATOM   916  C CG2 . VAL A 1 152 ? 179.16200 314.11200 11.13900  1.000 74.12346  ? 187 VAL F CG2 1 
ATOM   917  N N   . LEU A 1 153 ? 176.44300 312.35600 11.80100  1.000 79.68427  ? 188 LEU F N   1 
ATOM   918  C CA  . LEU A 1 153 ? 175.13800 311.98500 11.29400  1.000 78.04718  ? 188 LEU F CA  1 
ATOM   919  C C   . LEU A 1 153 ? 175.03100 312.53400 9.87700   1.000 82.65838  ? 188 LEU F C   1 
ATOM   920  O O   . LEU A 1 153 ? 175.20400 313.74100 9.65300   1.000 77.29479  ? 188 LEU F O   1 
ATOM   921  C CB  . LEU A 1 153 ? 174.02100 312.52300 12.18800  1.000 73.54008  ? 188 LEU F CB  1 
ATOM   922  C CG  . LEU A 1 153 ? 172.56700 312.23100 11.79700  1.000 84.37121  ? 188 LEU F CG  1 
ATOM   923  C CD1 . LEU A 1 153 ? 171.63100 312.60400 12.95100  1.000 81.11727  ? 188 LEU F CD1 1 
ATOM   924  C CD2 . LEU A 1 153 ? 172.13000 312.91200 10.48300  1.000 83.60444  ? 188 LEU F CD2 1 
ATOM   925  N N   . THR A 1 154 ? 174.82500 311.63800 8.91800   1.000 86.46124  ? 189 THR F N   1 
ATOM   926  C CA  . THR A 1 154 ? 174.77100 311.97500 7.50500   1.000 80.51444  ? 189 THR F CA  1 
ATOM   927  C C   . THR A 1 154 ? 173.32000 311.88700 7.06300   1.000 86.76587  ? 189 THR F C   1 
ATOM   928  O O   . THR A 1 154 ? 172.51100 311.17400 7.67100   1.000 87.28516  ? 189 THR F O   1 
ATOM   929  C CB  . THR A 1 154 ? 175.67700 311.07500 6.66400   1.000 76.46009  ? 189 THR F CB  1 
ATOM   930  O OG1 . THR A 1 154 ? 175.26800 309.71000 6.81600   1.000 84.84164  ? 189 THR F OG1 1 
ATOM   931  C CG2 . THR A 1 154 ? 177.13000 311.25400 7.04000   1.000 78.84232  ? 189 THR F CG2 1 
ATOM   932  N N   . SER A 1 155 ? 172.98600 312.64000 6.02200   1.000 80.46227  ? 190 SER F N   1 
ATOM   933  C CA  . SER A 1 155 ? 171.60800 312.67800 5.57000   1.000 78.15958  ? 190 SER F CA  1 
ATOM   934  C C   . SER A 1 155 ? 171.60300 312.93900 4.07500   1.000 73.61230  ? 190 SER F C   1 
ATOM   935  O O   . SER A 1 155 ? 172.54200 313.52500 3.52500   1.000 71.52146  ? 190 SER F O   1 
ATOM   936  C CB  . SER A 1 155 ? 170.81100 313.74000 6.33700   1.000 74.11055  ? 190 SER F CB  1 
ATOM   937  O OG  . SER A 1 155 ? 169.47000 313.78700 5.90500   1.000 76.64640  ? 190 SER F OG  1 
ATOM   938  N N   . LYS A 1 156 ? 170.54200 312.48200 3.41900   1.000 72.81153  ? 191 LYS F N   1 
ATOM   939  C CA  . LYS A 1 156 ? 170.39700 312.60100 1.97000   1.000 71.93346  ? 191 LYS F CA  1 
ATOM   940  C C   . LYS A 1 156 ? 169.03900 313.24800 1.70200   1.000 69.65428  ? 191 LYS F C   1 
ATOM   941  O O   . LYS A 1 156 ? 168.00300 312.59500 1.84000   1.000 70.96020  ? 191 LYS F O   1 
ATOM   942  C CB  . LYS A 1 156 ? 170.55100 311.27200 1.23000   1.000 76.17917  ? 191 LYS F CB  1 
ATOM   943  C CG  . LYS A 1 156 ? 170.43700 311.51600 -0.27800  1.000 74.28305  ? 191 LYS F CG  1 
ATOM   944  C CD  . LYS A 1 156 ? 169.77100 310.40100 -1.07400  1.000 78.65190  ? 191 LYS F CD  1 
ATOM   945  C CE  . LYS A 1 156 ? 170.75000 309.29000 -1.43200  1.000 78.18135  ? 191 LYS F CE  1 
ATOM   946  N NZ  . LYS A 1 156 ? 170.07800 307.95400 -1.42300  1.000 77.69600  ? 191 LYS F NZ  1 
ATOM   947  N N   . VAL A 1 157 ? 169.05500 314.56100 1.47200   1.000 69.07190  ? 192 VAL F N   1 
ATOM   948  C CA  . VAL A 1 157 ? 167.84200 315.36800 1.34400   1.000 67.68013  ? 192 VAL F CA  1 
ATOM   949  C C   . VAL A 1 157 ? 167.28500 315.43600 -0.08700  1.000 64.44905  ? 192 VAL F C   1 
ATOM   950  O O   . VAL A 1 157 ? 166.15600 315.92100 -0.27800  1.000 58.62339  ? 192 VAL F O   1 
ATOM   951  C CB  . VAL A 1 157 ? 168.11800 316.78100 1.89000   1.000 64.11649  ? 192 VAL F CB  1 
ATOM   952  C CG1 . VAL A 1 157 ? 168.52800 316.69100 3.34600   1.000 63.63420  ? 192 VAL F CG1 1 
ATOM   953  C CG2 . VAL A 1 157 ? 169.24100 317.44900 1.08600   1.000 55.15567  ? 192 VAL F CG2 1 
ATOM   954  N N   . LEU A 1 158 ? 168.07400 315.06400 -1.10100  1.000 58.25526  ? 193 LEU F N   1 
ATOM   955  C CA  . LEU A 1 158 ? 167.62500 315.10900 -2.48800  1.000 56.51998  ? 193 LEU F CA  1 
ATOM   956  C C   . LEU A 1 158 ? 168.32600 314.01000 -3.28300  1.000 61.81315  ? 193 LEU F C   1 
ATOM   957  O O   . LEU A 1 158 ? 169.54200 313.82800 -3.16300  1.000 59.07935  ? 193 LEU F O   1 
ATOM   958  C CB  . LEU A 1 158 ? 167.86500 316.48400 -3.12000  1.000 61.63749  ? 193 LEU F CB  1 
ATOM   959  C CG  . LEU A 1 158 ? 167.32000 316.68900 -4.54100  1.000 61.05905  ? 193 LEU F CG  1 
ATOM   960  C CD1 . LEU A 1 158 ? 165.81100 316.55000 -4.56600  1.000 60.65186  ? 193 LEU F CD1 1 
ATOM   961  C CD2 . LEU A 1 158 ? 167.71200 318.05800 -5.07600  1.000 56.33834  ? 193 LEU F CD2 1 
ATOM   962  N N   . ASP A 1 159 ? 167.57100 313.33500 -4.15300  1.000 69.27701  ? 194 ASP F N   1 
ATOM   963  C CA  . ASP A 1 159 ? 168.07100 312.21600 -4.96600  1.000 68.32071  ? 194 ASP F CA  1 
ATOM   964  C C   . ASP A 1 159 ? 167.85300 312.48900 -6.44300  1.000 64.62072  ? 194 ASP F C   1 
ATOM   965  O O   . ASP A 1 159 ? 166.84200 312.10700 -7.03300  1.000 68.97440  ? 194 ASP F O   1 
ATOM   966  C CB  . ASP A 1 159 ? 167.38300 310.91200 -4.57500  1.000 71.92955  ? 194 ASP F CB  1 
ATOM   967  C CG  . ASP A 1 159 ? 168.10000 309.67700 -5.11400  1.000 76.44567  ? 194 ASP F CG  1 
ATOM   968  O OD1 . ASP A 1 159 ? 169.31100 309.73000 -5.44700  1.000 73.03858  ? 194 ASP F OD1 1 
ATOM   969  O OD2 . ASP A 1 159 ? 167.41600 308.63700 -5.21600  1.000 78.82498  ? 194 ASP F OD2 1 
ATOM   970  N N   . LEU A 1 160 ? 168.83500 313.12300 -7.04900  1.000 60.12202  ? 195 LEU F N   1 
ATOM   971  C CA  . LEU A 1 160 ? 168.75800 313.37600 -8.46900  1.000 60.99461  ? 195 LEU F CA  1 
ATOM   972  C C   . LEU A 1 160 ? 169.32500 312.23000 -9.28400  1.000 65.73741  ? 195 LEU F C   1 
ATOM   973  O O   . LEU A 1 160 ? 168.94300 312.07500 -10.44800 1.000 70.30415  ? 195 LEU F O   1 
ATOM   974  C CB  . LEU A 1 160 ? 169.47200 314.68000 -8.81000  1.000 63.08308  ? 195 LEU F CB  1 
ATOM   975  C CG  . LEU A 1 160 ? 168.73900 315.93400 -8.32500  1.000 58.50677  ? 195 LEU F CG  1 
ATOM   976  C CD1 . LEU A 1 160 ? 169.50400 317.18300 -8.74600  1.000 56.56825  ? 195 LEU F CD1 1 
ATOM   977  C CD2 . LEU A 1 160 ? 167.32400 315.97100 -8.85700  1.000 58.16582  ? 195 LEU F CD2 1 
ATOM   978  N N   . LYS A 1 161 ? 170.25400 311.43600 -8.73300  1.000 69.22178  ? 196 LYS F N   1 
ATOM   979  C CA  . LYS A 1 161 ? 170.75300 310.30900 -9.51600  1.000 74.46958  ? 196 LYS F CA  1 
ATOM   980  C C   . LYS A 1 161 ? 169.67100 309.27300 -9.79600  1.000 74.19160  ? 196 LYS F C   1 
ATOM   981  O O   . LYS A 1 161 ? 169.58800 308.74300 -10.90700 1.000 76.73486  ? 196 LYS F O   1 
ATOM   982  C CB  . LYS A 1 161 ? 171.90400 309.61900 -8.78200  1.000 71.09679  ? 196 LYS F CB  1 
ATOM   983  C CG  . LYS A 1 161 ? 172.46900 308.46900 -9.60800  1.000 81.47878  ? 196 LYS F CG  1 
ATOM   984  C CD  . LYS A 1 161 ? 173.70000 307.79500 -9.03400  1.000 78.97292  ? 196 LYS F CD  1 
ATOM   985  C CE  . LYS A 1 161 ? 174.08200 306.60300 -9.91300  1.000 84.02823  ? 196 LYS F CE  1 
ATOM   986  N NZ  . LYS A 1 161 ? 172.97900 305.59200 -10.02700 1.000 82.63050  ? 196 LYS F NZ  1 
ATOM   987  N N   . ASN A 1 162 ? 168.82900 308.96800 -8.81400  1.000 74.24721  ? 197 ASN F N   1 
ATOM   988  C CA  . ASN A 1 162 ? 167.75900 308.01000 -9.06700  1.000 69.70197  ? 197 ASN F CA  1 
ATOM   989  C C   . ASN A 1 162 ? 166.73000 308.55900 -10.03900 1.000 73.49536  ? 197 ASN F C   1 
ATOM   990  O O   . ASN A 1 162 ? 166.23500 307.83100 -10.90500 1.000 82.76142  ? 197 ASN F O   1 
ATOM   991  C CB  . ASN A 1 162 ? 167.12200 307.51300 -7.77900  1.000 79.58752  ? 197 ASN F CB  1 
ATOM   992  C CG  . ASN A 1 162 ? 167.68200 306.15500 -7.37500  1.000 88.09827  ? 197 ASN F CG  1 
ATOM   993  O OD1 . ASN A 1 162 ? 168.79100 305.78600 -7.79300  1.000 82.13746  ? 197 ASN F OD1 1 
ATOM   994  N ND2 . ASN A 1 162 ? 166.90800 305.38800 -6.60100  1.000 92.47227  ? 197 ASN F ND2 1 
ATOM   995  N N   . TYR A 1 163 ? 166.42400 309.85000 -9.93900  1.000 67.40520  ? 198 TYR F N   1 
ATOM   996  C CA  . TYR A 1 163 ? 165.38900 310.41600 -10.79400 1.000 64.35808  ? 198 TYR F CA  1 
ATOM   997  C C   . TYR A 1 163 ? 165.86300 310.61600 -12.21500 1.000 67.80705  ? 198 TYR F C   1 
ATOM   998  O O   . TYR A 1 163 ? 165.11500 310.35000 -13.16000 1.000 71.46726  ? 198 TYR F O   1 
ATOM   999  C CB  . TYR A 1 163 ? 164.94800 311.75600 -10.22900 1.000 63.00048  ? 198 TYR F CB  1 
ATOM   1000 C CG  . TYR A 1 163 ? 163.73800 312.32400 -10.89700 1.000 60.83925  ? 198 TYR F CG  1 
ATOM   1001 C CD1 . TYR A 1 163 ? 163.88600 313.09200 -12.04200 1.000 55.33652  ? 198 TYR F CD1 1 
ATOM   1002 C CD2 . TYR A 1 163 ? 162.46500 312.12100 -10.39600 1.000 63.37588  ? 198 TYR F CD2 1 
ATOM   1003 C CE1 . TYR A 1 163 ? 162.80700 313.63400 -12.66700 1.000 55.21385  ? 198 TYR F CE1 1 
ATOM   1004 C CE2 . TYR A 1 163 ? 161.36900 312.65900 -11.02000 1.000 55.61194  ? 198 TYR F CE2 1 
ATOM   1005 C CZ  . TYR A 1 163 ? 161.54800 313.41600 -12.15100 1.000 59.44178  ? 198 TYR F CZ  1 
ATOM   1006 O OH  . TYR A 1 163 ? 160.44900 313.95900 -12.77600 1.000 72.47783  ? 198 TYR F OH  1 
ATOM   1007 N N   . ILE A 1 164 ? 167.09200 311.07200 -12.39800 1.000 67.69860  ? 199 ILE F N   1 
ATOM   1008 C CA  . ILE A 1 164 ? 167.54700 311.31200 -13.75300 1.000 68.46795  ? 199 ILE F CA  1 
ATOM   1009 C C   . ILE A 1 164 ? 167.76100 309.97700 -14.45100 1.000 73.78204  ? 199 ILE F C   1 
ATOM   1010 O O   . ILE A 1 164 ? 167.40600 309.80600 -15.62300 1.000 76.63314  ? 199 ILE F O   1 
ATOM   1011 C CB  . ILE A 1 164 ? 168.77500 312.22400 -13.75800 1.000 64.65426  ? 199 ILE F CB  1 
ATOM   1012 C CG1 . ILE A 1 164 ? 168.29900 313.57200 -13.23100 1.000 58.54830  ? 199 ILE F CG1 1 
ATOM   1013 C CG2 . ILE A 1 164 ? 169.32800 312.35300 -15.15500 1.000 69.63856  ? 199 ILE F CG2 1 
ATOM   1014 C CD1 . ILE A 1 164 ? 169.35100 314.64100 -13.17300 1.000 61.04133  ? 199 ILE F CD1 1 
ATOM   1015 N N   . ASP A 1 165 ? 168.34900 309.01000 -13.74300 1.000 73.96621  ? 200 ASP F N   1 
ATOM   1016 C CA  . ASP A 1 165 ? 168.68500 307.72800 -14.35300 1.000 76.11351  ? 200 ASP F CA  1 
ATOM   1017 C C   . ASP A 1 165 ? 167.45500 306.85200 -14.59100 1.000 78.26199  ? 200 ASP F C   1 
ATOM   1018 O O   . ASP A 1 165 ? 167.44700 306.05100 -15.53200 1.000 82.48021  ? 200 ASP F O   1 
ATOM   1019 C CB  . ASP A 1 165 ? 169.68300 306.97900 -13.47100 1.000 72.97314  ? 200 ASP F CB  1 
ATOM   1020 C CG  . ASP A 1 165 ? 171.03000 307.67800 -13.39600 1.000 79.80826  ? 200 ASP F CG  1 
ATOM   1021 O OD1 . ASP A 1 165 ? 171.04400 308.92800 -13.43200 1.000 81.77473  ? 200 ASP F OD1 1 
ATOM   1022 O OD2 . ASP A 1 165 ? 172.07400 306.99000 -13.31900 1.000 81.18762  ? 200 ASP F OD2 1 
ATOM   1023 N N   . LYS A 1 166 ? 166.38000 307.04500 -13.82800 1.000 76.87900  ? 201 LYS F N   1 
ATOM   1024 C CA  . LYS A 1 166 ? 165.19000 306.21300 -13.98500 1.000 75.01986  ? 201 LYS F CA  1 
ATOM   1025 C C   . LYS A 1 166 ? 164.14000 306.83000 -14.91000 1.000 76.93814  ? 201 LYS F C   1 
ATOM   1026 O O   . LYS A 1 166 ? 163.50200 306.10900 -15.68400 1.000 82.58975  ? 201 LYS F O   1 
ATOM   1027 C CB  . LYS A 1 166 ? 164.56500 305.93600 -12.61600 1.000 76.14710  ? 201 LYS F CB  1 
ATOM   1028 C CG  . LYS A 1 166 ? 165.34000 304.94000 -11.75500 1.000 76.34135  ? 201 LYS F CG  1 
ATOM   1029 C CD  . LYS A 1 166 ? 164.57300 304.65200 -10.47500 1.000 78.68368  ? 201 LYS F CD  1 
ATOM   1030 C CE  . LYS A 1 166 ? 165.23400 303.58200 -9.63600  1.000 83.23164  ? 201 LYS F CE  1 
ATOM   1031 N NZ  . LYS A 1 166 ? 164.43600 303.33900 -8.40000  1.000 88.14515  ? 201 LYS F NZ  1 
ATOM   1032 N N   . GLN A 1 167 ? 163.93800 308.14600 -14.83700 1.000 75.96296  ? 202 GLN F N   1 
ATOM   1033 C CA  . GLN A 1 167 ? 162.88600 308.84900 -15.55800 1.000 69.22069  ? 202 GLN F CA  1 
ATOM   1034 C C   . GLN A 1 167 ? 163.36100 309.65500 -16.75700 1.000 69.83967  ? 202 GLN F C   1 
ATOM   1035 O O   . GLN A 1 167 ? 162.55100 309.96500 -17.63300 1.000 77.78115  ? 202 GLN F O   1 
ATOM   1036 C CB  . GLN A 1 167 ? 162.15200 309.78800 -14.60500 1.000 69.39213  ? 202 GLN F CB  1 
ATOM   1037 C CG  . GLN A 1 167 ? 161.90900 309.13200 -13.27600 1.000 73.74678  ? 202 GLN F CG  1 
ATOM   1038 C CD  . GLN A 1 167 ? 160.46100 308.84700 -13.07300 1.000 75.42912  ? 202 GLN F CD  1 
ATOM   1039 O OE1 . GLN A 1 167 ? 159.62900 309.75500 -13.15500 1.000 76.82779  ? 202 GLN F OE1 1 
ATOM   1040 N NE2 . GLN A 1 167 ? 160.13300 307.58200 -12.83600 1.000 77.89489  ? 202 GLN F NE2 1 
ATOM   1041 N N   . LEU A 1 168 ? 164.62500 310.03900 -16.79500 1.000 72.08498  ? 203 LEU F N   1 
ATOM   1042 C CA  . LEU A 1 168 ? 165.18900 310.90700 -17.82300 1.000 75.63109  ? 203 LEU F CA  1 
ATOM   1043 C C   . LEU A 1 168 ? 166.11500 310.20400 -18.80100 1.000 78.98147  ? 203 LEU F C   1 
ATOM   1044 O O   . LEU A 1 168 ? 166.06700 310.50800 -19.99000 1.000 86.76132  ? 203 LEU F O   1 
ATOM   1045 C CB  . LEU A 1 168 ? 165.89000 312.11800 -17.19800 1.000 75.74586  ? 203 LEU F CB  1 
ATOM   1046 C CG  . LEU A 1 168 ? 164.93500 313.01100 -16.39000 1.000 64.89282  ? 203 LEU F CG  1 
ATOM   1047 C CD1 . LEU A 1 168 ? 165.60200 314.31100 -15.96700 1.000 58.55827  ? 203 LEU F CD1 1 
ATOM   1048 C CD2 . LEU A 1 168 ? 163.68700 313.29300 -17.18300 1.000 59.66108  ? 203 LEU F CD2 1 
ATOM   1049 N N   . LEU A 1 169 ? 166.98500 309.30300 -18.34700 1.000 80.36347  ? 204 LEU F N   1 
ATOM   1050 C CA  . LEU A 1 169 ? 167.92100 308.66500 -19.27000 1.000 85.74778  ? 204 LEU F CA  1 
ATOM   1051 C C   . LEU A 1 169 ? 167.23500 307.85800 -20.36700 1.000 90.25542  ? 204 LEU F C   1 
ATOM   1052 O O   . LEU A 1 169 ? 167.67200 307.96900 -21.52500 1.000 93.00356  ? 204 LEU F O   1 
ATOM   1053 C CB  . LEU A 1 169 ? 168.91800 307.77600 -18.51000 1.000 88.90327  ? 204 LEU F CB  1 
ATOM   1054 C CG  . LEU A 1 169 ? 169.95100 308.49900 -17.64900 1.000 90.70669  ? 204 LEU F CG  1 
ATOM   1055 C CD1 . LEU A 1 169 ? 170.94500 307.48500 -17.11300 1.000 89.38580  ? 204 LEU F CD1 1 
ATOM   1056 C CD2 . LEU A 1 169 ? 170.65700 309.64100 -18.41100 1.000 92.31688  ? 204 LEU F CD2 1 
ATOM   1057 N N   . PRO A 1 170 ? 166.18600 307.06800 -20.11600 1.000 90.73478  ? 205 PRO F N   1 
ATOM   1058 C CA  . PRO A 1 170 ? 165.49700 306.42100 -21.25300 1.000 89.50665  ? 205 PRO F CA  1 
ATOM   1059 C C   . PRO A 1 170 ? 164.93200 307.44300 -22.23700 1.000 85.17173  ? 205 PRO F C   1 
ATOM   1060 O O   . PRO A 1 170 ? 164.59500 307.07400 -23.37700 1.000 93.40587  ? 205 PRO F O   1 
ATOM   1061 C CB  . PRO A 1 170 ? 164.37900 305.59800 -20.57400 1.000 86.86591  ? 205 PRO F CB  1 
ATOM   1062 C CG  . PRO A 1 170 ? 164.88200 305.37600 -19.18600 1.000 85.10967  ? 205 PRO F CG  1 
ATOM   1063 C CD  . PRO A 1 170 ? 165.63000 306.63000 -18.82200 1.000 84.81579  ? 205 PRO F CD  1 
ATOM   1064 N N   . ILE A 1 171 ? 164.83300 308.70700 -21.80900 1.000 82.29358  ? 206 ILE F N   1 
ATOM   1065 C CA  . ILE A 1 171 ? 164.33300 309.80600 -22.62500 1.000 84.90587  ? 206 ILE F CA  1 
ATOM   1066 C C   . ILE A 1 171 ? 165.40600 310.51500 -23.47800 1.000 87.82348  ? 206 ILE F C   1 
ATOM   1067 O O   . ILE A 1 171 ? 165.05600 311.26900 -24.40000 1.000 88.93307  ? 206 ILE F O   1 
ATOM   1068 C CB  . ILE A 1 171 ? 163.62900 310.86100 -21.71800 1.000 82.76511  ? 206 ILE F CB  1 
ATOM   1069 C CG1 . ILE A 1 171 ? 162.37600 310.30100 -21.00800 1.000 82.52412  ? 206 ILE F CG1 1 
ATOM   1070 C CG2 . ILE A 1 171 ? 163.32700 312.09000 -22.41000 1.000 72.89982  ? 206 ILE F CG2 1 
ATOM   1071 C CD1 . ILE A 1 171 ? 161.30800 309.70900 -22.00800 1.000 82.61435  ? 206 ILE F CD1 1 
ATOM   1072 N N   . VAL A 1 172 ? 166.69800 310.33800 -23.19000 1.000 91.49889  ? 207 VAL F N   1 
ATOM   1073 C CA  . VAL A 1 172 ? 167.71500 311.03100 -23.98400 1.000 96.01721  ? 207 VAL F CA  1 
ATOM   1074 C C   . VAL A 1 172 ? 168.84400 310.08800 -24.37900 1.000 96.06096  ? 207 VAL F C   1 
ATOM   1075 O O   . VAL A 1 172 ? 169.87500 310.55000 -24.88300 1.000 95.42516  ? 207 VAL F O   1 
ATOM   1076 C CB  . VAL A 1 172 ? 168.28800 312.27800 -23.25600 1.000 96.81585  ? 207 VAL F CB  1 
ATOM   1077 C CG1 . VAL A 1 172 ? 167.26100 313.40800 -23.20700 1.000 90.59186  ? 207 VAL F CG1 1 
ATOM   1078 C CG2 . VAL A 1 172 ? 168.79500 311.93000 -21.84000 1.000 90.06085  ? 207 VAL F CG2 1 
ATOM   1079 N N   . ASN A 1 173 ? 168.67700 308.76900 -24.16800 1.000 98.74805  ? 208 ASN F N   1 
ATOM   1080 C CA  . ASN A 1 173 ? 169.77200 307.83400 -24.46300 1.000 105.93436 ? 208 ASN F CA  1 
ATOM   1081 C C   . ASN A 1 173 ? 169.30900 306.64600 -25.32800 1.000 109.01835 ? 208 ASN F C   1 
ATOM   1082 O O   . ASN A 1 173 ? 169.39300 305.47100 -24.95300 1.000 105.33474 ? 208 ASN F O   1 
ATOM   1083 C CB  . ASN A 1 173 ? 170.41400 307.33200 -23.17200 1.000 102.36013 ? 208 ASN F CB  1 
ATOM   1084 C CG  . ASN A 1 173 ? 171.80400 307.91800 -22.95100 1.000 111.61912 ? 208 ASN F CG  1 
ATOM   1085 O OD1 . ASN A 1 173 ? 172.54800 308.18400 -23.90200 1.000 110.81668 ? 208 ASN F OD1 1 
ATOM   1086 N ND2 . ASN A 1 173 ? 172.15300 308.13900 -21.68000 1.000 106.34640 ? 208 ASN F ND2 1 
ATOM   1087 N N   . LYS A 1 174 ? 168.79000 306.99900 -26.50300 1.000 109.60167 ? 209 LYS F N   1 
ATOM   1088 C CA  . LYS A 1 174 ? 168.34100 306.11600 -27.57700 1.000 110.73314 ? 209 LYS F CA  1 
ATOM   1089 C C   . LYS A 1 174 ? 168.77600 306.81900 -28.85900 1.000 112.04063 ? 209 LYS F C   1 
ATOM   1090 O O   . LYS A 1 174 ? 169.50900 307.81500 -28.81500 1.000 109.54590 ? 209 LYS F O   1 
ATOM   1091 C CB  . LYS A 1 174 ? 166.83900 305.79400 -27.55700 1.000 110.94956 ? 209 LYS F CB  1 
ATOM   1092 C CG  . LYS A 1 174 ? 165.90200 306.83300 -26.97800 1.000 107.26747 ? 209 LYS F CG  1 
ATOM   1093 C CD  . LYS A 1 174 ? 164.48500 306.26100 -27.01300 1.000 99.19856  ? 209 LYS F CD  1 
ATOM   1094 C CE  . LYS A 1 174 ? 164.46300 304.79900 -26.57300 1.000 88.45116  ? 209 LYS F CE  1 
ATOM   1095 N NZ  . LYS A 1 174 ? 164.34700 304.66500 -25.10700 1.000 80.86075  ? 209 LYS F NZ  1 
ATOM   1096 N N   . GLN A 1 175 ? 168.36500 306.29700 -30.01600 1.000 113.20300 ? 210 GLN F N   1 
ATOM   1097 C CA  . GLN A 1 175 ? 168.66200 307.01900 -31.25400 1.000 124.80242 ? 210 GLN F CA  1 
ATOM   1098 C C   . GLN A 1 175 ? 167.82100 308.29500 -31.30200 1.000 126.45108 ? 210 GLN F C   1 
ATOM   1099 O O   . GLN A 1 175 ? 168.35000 309.39400 -31.52500 1.000 126.70842 ? 210 GLN F O   1 
ATOM   1100 C CB  . GLN A 1 175 ? 168.44100 306.15500 -32.50500 1.000 122.75353 ? 210 GLN F CB  1 
ATOM   1101 C CG  . GLN A 1 175 ? 168.42700 306.96200 -33.84100 1.000 120.84140 ? 210 GLN F CG  1 
ATOM   1102 C CD  . GLN A 1 175 ? 169.81400 307.41600 -34.32700 1.000 124.03579 ? 210 GLN F CD  1 
ATOM   1103 O OE1 . GLN A 1 175 ? 170.74900 306.62100 -34.41800 1.000 127.67023 ? 210 GLN F OE1 1 
ATOM   1104 N NE2 . GLN A 1 175 ? 169.93900 308.70700 -34.64800 1.000 117.37264 ? 210 GLN F NE2 1 
ATOM   1105 N N   . SER A 1 176 ? 166.50100 308.16100 -31.10500 1.000 125.09843 ? 211 SER F N   1 
ATOM   1106 C CA  . SER A 1 176 ? 165.57900 309.29000 -30.97500 1.000 119.34381 ? 211 SER F CA  1 
ATOM   1107 C C   . SER A 1 176 ? 164.99100 309.31300 -29.56300 1.000 112.82274 ? 211 SER F C   1 
ATOM   1108 O O   . SER A 1 176 ? 164.69700 308.26400 -28.97500 1.000 108.90498 ? 211 SER F O   1 
ATOM   1109 C CB  . SER A 1 176 ? 164.44900 309.21800 -32.00800 1.000 118.84117 ? 211 SER F CB  1 
ATOM   1110 O OG  . SER A 1 176 ? 164.90900 309.55900 -33.30600 1.000 120.67417 ? 211 SER F OG  1 
ATOM   1111 N N   . CYS A 1 177 ? 164.79900 310.52300 -29.03900 1.000 114.21617 ? 212 CYS F N   1 
ATOM   1112 C CA  . CYS A 1 177 ? 164.35000 310.72200 -27.66400 1.000 107.40773 ? 212 CYS F CA  1 
ATOM   1113 C C   . CYS A 1 177 ? 162.93300 310.18500 -27.44200 1.000 96.82800  ? 212 CYS F C   1 
ATOM   1114 O O   . CYS A 1 177 ? 162.03500 310.40400 -28.26000 1.000 98.24110  ? 212 CYS F O   1 
ATOM   1115 C CB  . CYS A 1 177 ? 164.40200 312.22000 -27.32200 1.000 89.57982  ? 212 CYS F CB  1 
ATOM   1116 S SG  . CYS A 1 177 ? 165.87200 313.19600 -27.94300 1.000 127.40483 ? 212 CYS F SG  1 
ATOM   1117 N N   . SER A 1 178 ? 162.72100 309.49600 -26.31800 1.000 83.86086  ? 213 SER F N   1 
ATOM   1118 C CA  . SER A 1 178 ? 161.35100 309.16900 -25.96000 1.000 78.52737  ? 213 SER F CA  1 
ATOM   1119 C C   . SER A 1 178 ? 160.61900 310.38500 -25.39100 1.000 75.71834  ? 213 SER F C   1 
ATOM   1120 O O   . SER A 1 178 ? 161.22000 311.32700 -24.86900 1.000 74.61703  ? 213 SER F O   1 
ATOM   1121 C CB  . SER A 1 178 ? 161.33400 308.05400 -24.91300 1.000 77.86151  ? 213 SER F CB  1 
ATOM   1122 O OG  . SER A 1 178 ? 160.01000 307.65200 -24.59900 1.000 80.60549  ? 213 SER F OG  1 
ATOM   1123 N N   . ILE A 1 179 ? 159.29400 310.35100 -25.49400 1.000 73.51217  ? 214 ILE F N   1 
ATOM   1124 C CA  . ILE A 1 179 ? 158.43800 311.45900 -25.08400 1.000 65.96788  ? 214 ILE F CA  1 
ATOM   1125 C C   . ILE A 1 179 ? 158.09500 311.26500 -23.60900 1.000 65.42431  ? 214 ILE F C   1 
ATOM   1126 O O   . ILE A 1 179 ? 157.41400 310.28000 -23.27300 1.000 70.99896  ? 214 ILE F O   1 
ATOM   1127 C CB  . ILE A 1 179 ? 157.18900 311.62200 -25.95500 1.000 66.21971  ? 214 ILE F CB  1 
ATOM   1128 C CG1 . ILE A 1 179 ? 157.59200 311.80600 -27.41600 1.000 62.78678  ? 214 ILE F CG1 1 
ATOM   1129 C CG2 . ILE A 1 179 ? 156.42900 312.87500 -25.53100 1.000 64.05747  ? 214 ILE F CG2 1 
ATOM   1130 C CD1 . ILE A 1 179 ? 158.54600 312.92500 -27.61400 1.000 64.69233  ? 214 ILE F CD1 1 
ATOM   1131 N N   . PRO A 1 180 ? 158.54200 312.13400 -22.72300 1.000 62.50807  ? 215 PRO F N   1 
ATOM   1132 C CA  . PRO A 1 180 ? 158.15300 312.03800 -21.31900 1.000 58.76975  ? 215 PRO F CA  1 
ATOM   1133 C C   . PRO A 1 180 ? 156.80700 312.69800 -21.09900 1.000 57.30832  ? 215 PRO F C   1 
ATOM   1134 O O   . PRO A 1 180 ? 156.39400 313.58700 -21.84500 1.000 58.03167  ? 215 PRO F O   1 
ATOM   1135 C CB  . PRO A 1 180 ? 159.26400 312.81100 -20.60800 1.000 62.61832  ? 215 PRO F CB  1 
ATOM   1136 C CG  . PRO A 1 180 ? 159.62000 313.88000 -21.61500 1.000 56.71751  ? 215 PRO F CG  1 
ATOM   1137 C CD  . PRO A 1 180 ? 159.42700 313.28600 -22.97500 1.000 56.77303  ? 215 PRO F CD  1 
ATOM   1138 N N   . ASN A 1 181 ? 156.08500 312.20200 -20.10300 1.000 51.00721  ? 216 ASN F N   1 
ATOM   1139 C CA  . ASN A 1 181 ? 154.79000 312.79500 -19.82500 1.000 51.54253  ? 216 ASN F CA  1 
ATOM   1140 C C   . ASN A 1 181 ? 155.00200 314.14700 -19.14500 1.000 55.41116  ? 216 ASN F C   1 
ATOM   1141 O O   . ASN A 1 181 ? 156.03900 314.40400 -18.53000 1.000 59.97272  ? 216 ASN F O   1 
ATOM   1142 C CB  . ASN A 1 181 ? 153.96600 311.90000 -18.91400 1.000 56.96461  ? 216 ASN F CB  1 
ATOM   1143 C CG  . ASN A 1 181 ? 154.74600 311.41300 -17.72500 1.000 53.29273  ? 216 ASN F CG  1 
ATOM   1144 O OD1 . ASN A 1 181 ? 155.85300 310.88300 -17.85100 1.000 62.61046  ? 216 ASN F OD1 1 
ATOM   1145 N ND2 . ASN A 1 181 ? 154.18200 311.61300 -16.55000 1.000 49.84163  ? 216 ASN F ND2 1 
ATOM   1146 N N   . ILE A 1 182 ? 153.98500 315.00700 -19.23100 1.000 50.33749  ? 217 ILE F N   1 
ATOM   1147 C CA  . ILE A 1 182 ? 154.09000 316.35300 -18.67500 1.000 49.86336  ? 217 ILE F CA  1 
ATOM   1148 C C   . ILE A 1 182 ? 154.26100 316.40700 -17.15600 1.000 55.09816  ? 217 ILE F C   1 
ATOM   1149 O O   . ILE A 1 182 ? 154.78000 317.40200 -16.63800 1.000 55.46005  ? 217 ILE F O   1 
ATOM   1150 C CB  . ILE A 1 182 ? 152.83000 317.14900 -19.10400 1.000 47.50999  ? 217 ILE F CB  1 
ATOM   1151 C CG1 . ILE A 1 182 ? 153.06700 318.65700 -19.01600 1.000 46.50907  ? 217 ILE F CG1 1 
ATOM   1152 C CG2 . ILE A 1 182 ? 151.61700 316.74800 -18.28600 1.000 41.66518  ? 217 ILE F CG2 1 
ATOM   1153 C CD1 . ILE A 1 182 ? 154.17600 319.15800 -19.92500 1.000 47.46509  ? 217 ILE F CD1 1 
ATOM   1154 N N   . GLU A 1 183 ? 153.84400 315.37300 -16.42500 1.000 57.05779  ? 218 GLU F N   1 
ATOM   1155 C CA  . GLU A 1 183 ? 154.08900 315.31600 -14.98400 1.000 48.91464  ? 218 GLU F CA  1 
ATOM   1156 C C   . GLU A 1 183 ? 155.57800 315.20900 -14.65800 1.000 50.90838  ? 218 GLU F C   1 
ATOM   1157 O O   . GLU A 1 183 ? 156.06000 315.83300 -13.70900 1.000 53.80134  ? 218 GLU F O   1 
ATOM   1158 C CB  . GLU A 1 183 ? 153.34600 314.13100 -14.39300 1.000 54.69146  ? 218 GLU F CB  1 
ATOM   1159 C CG  . GLU A 1 183 ? 151.84600 314.27300 -14.45500 1.000 61.49627  ? 218 GLU F CG  1 
ATOM   1160 C CD  . GLU A 1 183 ? 151.31300 313.82500 -15.82400 1.000 63.93211  ? 218 GLU F CD  1 
ATOM   1161 O OE1 . GLU A 1 183 ? 152.14200 313.40000 -16.67500 1.000 65.19295  ? 218 GLU F OE1 1 
ATOM   1162 O OE2 . GLU A 1 183 ? 150.07300 313.85000 -16.02500 1.000 59.41551  ? 218 GLU F OE2 1 
ATOM   1163 N N   . THR A 1 184 ? 156.33000 314.46600 -15.46300 1.000 50.19429  ? 219 THR F N   1 
ATOM   1164 C CA  . THR A 1 184 ? 157.76200 314.34000 -15.23500 1.000 50.81145  ? 219 THR F CA  1 
ATOM   1165 C C   . THR A 1 184 ? 158.45900 315.67200 -15.46500 1.000 52.05468  ? 219 THR F C   1 
ATOM   1166 O O   . THR A 1 184 ? 159.35200 316.05500 -14.70300 1.000 56.51860  ? 219 THR F O   1 
ATOM   1167 C CB  . THR A 1 184 ? 158.34400 313.27200 -16.16300 1.000 51.66150  ? 219 THR F CB  1 
ATOM   1168 O OG1 . THR A 1 184 ? 157.76700 311.99700 -15.86200 1.000 48.13105  ? 219 THR F OG1 1 
ATOM   1169 C CG2 . THR A 1 184 ? 159.84200 313.20400 -16.00800 1.000 50.90919  ? 219 THR F CG2 1 
ATOM   1170 N N   . VAL A 1 185 ? 158.03900 316.41200 -16.48300 1.000 47.55729  ? 220 VAL F N   1 
ATOM   1171 C CA  . VAL A 1 185 ? 158.65200 317.70400 -16.75300 1.000 49.20561  ? 220 VAL F CA  1 
ATOM   1172 C C   . VAL A 1 185 ? 158.47700 318.62500 -15.55600 1.000 54.68608  ? 220 VAL F C   1 
ATOM   1173 O O   . VAL A 1 185 ? 159.41000 319.32700 -15.15400 1.000 52.99166  ? 220 VAL F O   1 
ATOM   1174 C CB  . VAL A 1 185 ? 158.03100 318.31900 -18.01700 1.000 49.94365  ? 220 VAL F CB  1 
ATOM   1175 C CG1 . VAL A 1 185 ? 158.58800 319.70200 -18.27600 1.000 50.95061  ? 220 VAL F CG1 1 
ATOM   1176 C CG2 . VAL A 1 185 ? 158.24800 317.40900 -19.19700 1.000 55.74085  ? 220 VAL F CG2 1 
ATOM   1177 N N   . ILE A 1 186 ? 157.29400 318.61100 -14.94200 1.000 53.88240  ? 221 ILE F N   1 
ATOM   1178 C CA  . ILE A 1 186 ? 157.06200 319.49100 -13.80800 1.000 50.40042  ? 221 ILE F CA  1 
ATOM   1179 C C   . ILE A 1 186 ? 157.79500 318.97900 -12.57700 1.000 51.70949  ? 221 ILE F C   1 
ATOM   1180 O O   . ILE A 1 186 ? 158.41400 319.75600 -11.83900 1.000 45.08230  ? 221 ILE F O   1 
ATOM   1181 C CB  . ILE A 1 186 ? 155.55100 319.63300 -13.55900 1.000 51.20000  ? 221 ILE F CB  1 
ATOM   1182 C CG1 . ILE A 1 186 ? 154.90100 320.38700 -14.72200 1.000 49.31939  ? 221 ILE F CG1 1 
ATOM   1183 C CG2 . ILE A 1 186 ? 155.28000 320.31800 -12.21300 1.000 52.29231  ? 221 ILE F CG2 1 
ATOM   1184 C CD1 . ILE A 1 186 ? 153.41900 320.57300 -14.56400 1.000 51.04722  ? 221 ILE F CD1 1 
ATOM   1185 N N   . GLU A 1 187 ? 157.77600 317.66400 -12.35000 1.000 54.29782  ? 222 GLU F N   1 
ATOM   1186 C CA  . GLU A 1 187 ? 158.46900 317.14200 -11.17900 1.000 50.14501  ? 222 GLU F CA  1 
ATOM   1187 C C   . GLU A 1 187 ? 159.96600 317.38500 -11.25100 1.000 51.07409  ? 222 GLU F C   1 
ATOM   1188 O O   . GLU A 1 187 ? 160.59600 317.63700 -10.21900 1.000 55.14957  ? 222 GLU F O   1 
ATOM   1189 C CB  . GLU A 1 187 ? 158.25900 315.64400 -11.01300 1.000 53.75830  ? 222 GLU F CB  1 
ATOM   1190 C CG  . GLU A 1 187 ? 158.54800 315.19500 -9.59000  1.000 62.14693  ? 222 GLU F CG  1 
ATOM   1191 C CD  . GLU A 1 187 ? 158.16300 313.76000 -9.31900  1.000 74.42637  ? 222 GLU F CD  1 
ATOM   1192 O OE1 . GLU A 1 187 ? 157.98100 312.98900 -10.29800 1.000 72.76025  ? 222 GLU F OE1 1 
ATOM   1193 O OE2 . GLU A 1 187 ? 158.02500 313.41500 -8.12000  1.000 80.25327  ? 222 GLU F OE2 1 
ATOM   1194 N N   . PHE A 1 188 ? 160.54800 317.40700 -12.45100 1.000 52.61826  ? 223 PHE F N   1 
ATOM   1195 C CA  . PHE A 1 188 ? 161.98500 317.64700 -12.52300 1.000 51.91394  ? 223 PHE F CA  1 
ATOM   1196 C C   . PHE A 1 188 ? 162.32500 319.10700 -12.30300 1.000 50.31855  ? 223 PHE F C   1 
ATOM   1197 O O   . PHE A 1 188 ? 163.35400 319.40200 -11.69400 1.000 52.62827  ? 223 PHE F O   1 
ATOM   1198 C CB  . PHE A 1 188 ? 162.53100 317.16000 -13.87400 1.000 49.43582  ? 223 PHE F CB  1 
ATOM   1199 C CG  . PHE A 1 188 ? 164.03200 317.28400 -14.02400 1.000 49.47449  ? 223 PHE F CG  1 
ATOM   1200 C CD1 . PHE A 1 188 ? 164.89500 316.83000 -13.03200 1.000 50.42185  ? 223 PHE F CD1 1 
ATOM   1201 C CD2 . PHE A 1 188 ? 164.58300 317.79200 -15.20000 1.000 50.96744  ? 223 PHE F CD2 1 
ATOM   1202 C CE1 . PHE A 1 188 ? 166.29000 316.93500 -13.18300 1.000 50.07870  ? 223 PHE F CE1 1 
ATOM   1203 C CE2 . PHE A 1 188 ? 165.97100 317.89500 -15.36400 1.000 48.80781  ? 223 PHE F CE2 1 
ATOM   1204 C CZ  . PHE A 1 188 ? 166.82300 317.46000 -14.35500 1.000 48.04945  ? 223 PHE F CZ  1 
ATOM   1205 N N   . GLN A 1 189 ? 161.45800 320.03100 -12.71100 1.000 50.26075  ? 224 GLN F N   1 
ATOM   1206 C CA  . GLN A 1 189 ? 161.73500 321.42600 -12.40800 1.000 49.31621  ? 224 GLN F CA  1 
ATOM   1207 C C   . GLN A 1 189 ? 161.62400 321.70800 -10.91400 1.000 53.70256  ? 224 GLN F C   1 
ATOM   1208 O O   . GLN A 1 189 ? 162.38400 322.52500 -10.38900 1.000 51.86601  ? 224 GLN F O   1 
ATOM   1209 C CB  . GLN A 1 189 ? 160.73700 322.28800 -13.16800 1.000 48.38134  ? 224 GLN F CB  1 
ATOM   1210 C CG  . GLN A 1 189 ? 160.93200 322.21900 -14.65700 1.000 61.26278  ? 224 GLN F CG  1 
ATOM   1211 C CD  . GLN A 1 189 ? 159.86000 322.97600 -15.42100 1.000 71.78380  ? 224 GLN F CD  1 
ATOM   1212 O OE1 . GLN A 1 189 ? 158.89000 323.47800 -14.83700 1.000 69.55303  ? 224 GLN F OE1 1 
ATOM   1213 N NE2 . GLN A 1 189 ? 160.02200 323.04400 -16.74400 1.000 70.83128  ? 224 GLN F NE2 1 
ATOM   1214 N N   . GLN A 1 190 ? 160.73600 320.99300 -10.20700 1.000 51.94087  ? 225 GLN F N   1 
ATOM   1215 C CA  . GLN A 1 190 ? 160.59500 321.16000 -8.76400  1.000 45.77277  ? 225 GLN F CA  1 
ATOM   1216 C C   . GLN A 1 190 ? 161.78800 320.56400 -8.01600  1.000 53.32122  ? 225 GLN F C   1 
ATOM   1217 O O   . GLN A 1 190 ? 162.34800 321.19800 -7.11000  1.000 55.80904  ? 225 GLN F O   1 
ATOM   1218 C CB  . GLN A 1 190 ? 159.30100 320.50100 -8.29000  1.000 53.76136  ? 225 GLN F CB  1 
ATOM   1219 C CG  . GLN A 1 190 ? 158.00500 321.03100 -8.90200  1.000 58.62451  ? 225 GLN F CG  1 
ATOM   1220 C CD  . GLN A 1 190 ? 157.65500 322.44100 -8.52000  1.000 68.00046  ? 225 GLN F CD  1 
ATOM   1221 O OE1 . GLN A 1 190 ? 157.74600 322.82300 -7.35000  1.000 74.22708  ? 225 GLN F OE1 1 
ATOM   1222 N NE2 . GLN A 1 190 ? 157.23000 323.23400 -9.51200  1.000 66.16440  ? 225 GLN F NE2 1 
ATOM   1223 N N   . LYS A 1 191 ? 162.21700 319.35500 -8.40000  1.000 51.05327  ? 226 LYS F N   1 
ATOM   1224 C CA  . LYS A 1 191 ? 163.34700 318.73000 -7.71800  1.000 52.14217  ? 226 LYS F CA  1 
ATOM   1225 C C   . LYS A 1 191 ? 164.63700 319.44700 -8.03200  1.000 53.73927  ? 226 LYS F C   1 
ATOM   1226 O O   . LYS A 1 191 ? 165.48100 319.63600 -7.15000  1.000 58.15227  ? 226 LYS F O   1 
ATOM   1227 C CB  . LYS A 1 191 ? 163.50700 317.23900 -8.05300  1.000 56.86575  ? 226 LYS F CB  1 
ATOM   1228 C CG  . LYS A 1 191 ? 162.58800 316.25700 -7.34000  1.000 57.20914  ? 226 LYS F CG  1 
ATOM   1229 C CD  . LYS A 1 191 ? 163.22700 314.84300 -7.44700  1.000 61.31218  ? 226 LYS F CD  1 
ATOM   1230 C CE  . LYS A 1 191 ? 162.57900 313.77200 -6.54400  1.000 57.22216  ? 226 LYS F CE  1 
ATOM   1231 N NZ  . LYS A 1 191 ? 161.10500 313.58600 -6.68600  1.000 67.27919  ? 226 LYS F NZ  1 
ATOM   1232 N N   . ASN A 1 192 ? 164.81300 319.85400 -9.27700  1.000 50.88613  ? 227 ASN F N   1 
ATOM   1233 C CA  . ASN A 1 192 ? 166.06200 320.48600 -9.64200  1.000 49.44310  ? 227 ASN F CA  1 
ATOM   1234 C C   . ASN A 1 192 ? 166.19400 321.86700 -9.01100  1.000 50.54543  ? 227 ASN F C   1 
ATOM   1235 O O   . ASN A 1 192 ? 167.31200 322.36900 -8.88100  1.000 54.02383  ? 227 ASN F O   1 
ATOM   1236 C CB  . ASN A 1 192 ? 166.09900 320.61500 -11.16600 1.000 47.35229  ? 227 ASN F CB  1 
ATOM   1237 C CG  . ASN A 1 192 ? 167.43900 320.96400 -11.68200 1.000 46.21088  ? 227 ASN F CG  1 
ATOM   1238 O OD1 . ASN A 1 192 ? 168.43700 320.56500 -11.10500 1.000 50.48190  ? 227 ASN F OD1 1 
ATOM   1239 N ND2 . ASN A 1 192 ? 167.49100 321.76100 -12.73700 1.000 51.21764  ? 227 ASN F ND2 1 
ATOM   1240 N N   . ASN A 1 193 ? 165.08500 322.45000 -8.53700  1.000 52.76676  ? 228 ASN F N   1 
ATOM   1241 C CA  . ASN A 1 193 ? 165.10500 323.82600 -8.04400  1.000 50.32185  ? 228 ASN F CA  1 
ATOM   1242 C C   . ASN A 1 193 ? 166.00100 323.96800 -6.82600  1.000 51.04821  ? 228 ASN F C   1 
ATOM   1243 O O   . ASN A 1 193 ? 166.76400 324.93700 -6.71200  1.000 53.76238  ? 228 ASN F O   1 
ATOM   1244 C CB  . ASN A 1 193 ? 163.69600 324.29500 -7.69000  1.000 50.15226  ? 228 ASN F CB  1 
ATOM   1245 C CG  . ASN A 1 193 ? 163.68900 325.70300 -7.21200  1.000 56.92490  ? 228 ASN F CG  1 
ATOM   1246 O OD1 . ASN A 1 193 ? 164.32400 326.55900 -7.81900  1.000 65.10479  ? 228 ASN F OD1 1 
ATOM   1247 N ND2 . ASN A 1 193 ? 163.09000 325.93700 -6.04700  1.000 55.75433  ? 228 ASN F ND2 1 
ATOM   1248 N N   . ARG A 1 194 ? 165.89600 323.02700 -5.89000  1.000 47.37926  ? 229 ARG F N   1 
ATOM   1249 C CA  . ARG A 1 194 ? 166.68700 323.10200 -4.67400  1.000 40.94048  ? 229 ARG F CA  1 
ATOM   1250 C C   . ARG A 1 194 ? 168.16100 323.01400 -4.94900  1.000 50.72871  ? 229 ARG F C   1 
ATOM   1251 O O   . ARG A 1 194 ? 168.95700 323.68500 -4.28600  1.000 53.50516  ? 229 ARG F O   1 
ATOM   1252 C CB  . ARG A 1 194 ? 166.27700 322.00500 -3.71100  1.000 47.10453  ? 229 ARG F CB  1 
ATOM   1253 C CG  . ARG A 1 194 ? 166.95400 322.08300 -2.38000  1.000 50.03889  ? 229 ARG F CG  1 
ATOM   1254 C CD  . ARG A 1 194 ? 166.35800 321.01700 -1.43000  1.000 48.20488  ? 229 ARG F CD  1 
ATOM   1255 N NE  . ARG A 1 194 ? 166.95100 321.12500 -0.10800  1.000 49.94063  ? 229 ARG F NE  1 
ATOM   1256 C CZ  . ARG A 1 194 ? 166.67300 320.33300 0.91600   1.000 58.23894  ? 229 ARG F CZ  1 
ATOM   1257 N NH1 . ARG A 1 194 ? 165.79600 319.34700 0.81200   1.000 64.47750  ? 229 ARG F NH1 1 
ATOM   1258 N NH2 . ARG A 1 194 ? 167.27700 320.55200 2.08200   1.000 56.70844  ? 229 ARG F NH2 1 
ATOM   1259 N N   . LEU A 1 195 ? 168.54600 322.24800 -5.95400  1.000 51.03853  ? 230 LEU F N   1 
ATOM   1260 C CA  . LEU A 1 195 ? 169.95100 322.22500 -6.28900  1.000 47.22177  ? 230 LEU F CA  1 
ATOM   1261 C C   . LEU A 1 195 ? 170.38900 323.60100 -6.76100  1.000 47.97627  ? 230 LEU F C   1 
ATOM   1262 O O   . LEU A 1 195 ? 171.44100 324.09700 -6.34500  1.000 52.02165  ? 230 LEU F O   1 
ATOM   1263 C CB  . LEU A 1 195 ? 170.21700 321.19400 -7.37900  1.000 47.85524  ? 230 LEU F CB  1 
ATOM   1264 C CG  . LEU A 1 195 ? 171.67300 321.22900 -7.83900  1.000 47.00994  ? 230 LEU F CG  1 
ATOM   1265 C CD1 . LEU A 1 195 ? 172.60800 320.88700 -6.71000  1.000 35.82447  ? 230 LEU F CD1 1 
ATOM   1266 C CD2 . LEU A 1 195 ? 171.95300 320.39600 -9.07100  1.000 51.67946  ? 230 LEU F CD2 1 
ATOM   1267 N N   . LEU A 1 196 ? 169.58100 324.24800 -7.60800  1.000 47.33304  ? 231 LEU F N   1 
ATOM   1268 C CA  . LEU A 1 196 ? 169.95300 325.56100 -8.13700  1.000 54.07139  ? 231 LEU F CA  1 
ATOM   1269 C C   . LEU A 1 196 ? 169.99800 326.61900 -7.03800  1.000 55.32093  ? 231 LEU F C   1 
ATOM   1270 O O   . LEU A 1 196 ? 170.84400 327.52500 -7.07500  1.000 59.31811  ? 231 LEU F O   1 
ATOM   1271 C CB  . LEU A 1 196 ? 168.99800 325.97000 -9.25300  1.000 51.83802  ? 231 LEU F CB  1 
ATOM   1272 C CG  . LEU A 1 196 ? 168.88200 324.93200 -10.37100 1.000 49.37455  ? 231 LEU F CG  1 
ATOM   1273 C CD1 . LEU A 1 196 ? 168.01900 325.43700 -11.49800 1.000 45.05289  ? 231 LEU F CD1 1 
ATOM   1274 C CD2 . LEU A 1 196 ? 170.26900 324.59200 -10.87900 1.000 50.29672  ? 231 LEU F CD2 1 
ATOM   1275 N N   . GLU A 1 197 ? 169.07900 326.55700 -6.07200  1.000 49.35514  ? 232 GLU F N   1 
ATOM   1276 C CA  . GLU A 1 197 ? 169.11800 327.56900 -5.02500  1.000 55.17156  ? 232 GLU F CA  1 
ATOM   1277 C C   . GLU A 1 197 ? 170.30200 327.33300 -4.10500  1.000 55.54469  ? 232 GLU F C   1 
ATOM   1278 O O   . GLU A 1 197 ? 170.88200 328.28500 -3.58300  1.000 61.38795  ? 232 GLU F O   1 
ATOM   1279 C CB  . GLU A 1 197 ? 167.80600 327.63500 -4.25100  1.000 57.18323  ? 232 GLU F CB  1 
ATOM   1280 C CG  . GLU A 1 197 ? 166.65100 328.01800 -5.17500  1.000 61.24974  ? 232 GLU F CG  1 
ATOM   1281 C CD  . GLU A 1 197 ? 166.67300 329.48500 -5.59100  1.000 68.49791  ? 232 GLU F CD  1 
ATOM   1282 O OE1 . GLU A 1 197 ? 167.50900 330.24900 -5.04300  1.000 72.51494  ? 232 GLU F OE1 1 
ATOM   1283 O OE2 . GLU A 1 197 ? 165.87100 329.85400 -6.48800  1.000 63.79665  ? 232 GLU F OE2 1 
ATOM   1284 N N   . ILE A 1 198 ? 170.67600 326.07600 -3.90100  1.000 51.81232  ? 233 ILE F N   1 
ATOM   1285 C CA  . ILE A 1 198 ? 171.84600 325.79500 -3.08800  1.000 46.94550  ? 233 ILE F CA  1 
ATOM   1286 C C   . ILE A 1 198 ? 173.07800 326.23900 -3.83700  1.000 49.98317  ? 233 ILE F C   1 
ATOM   1287 O O   . ILE A 1 198 ? 174.01800 326.77800 -3.25200  1.000 57.67427  ? 233 ILE F O   1 
ATOM   1288 C CB  . ILE A 1 198 ? 171.91900 324.30200 -2.72600  1.000 49.29997  ? 233 ILE F CB  1 
ATOM   1289 C CG1 . ILE A 1 198 ? 170.81900 323.94600 -1.73300  1.000 47.61174  ? 233 ILE F CG1 1 
ATOM   1290 C CG2 . ILE A 1 198 ? 173.30400 323.91600 -2.23000  1.000 48.38170  ? 233 ILE F CG2 1 
ATOM   1291 C CD1 . ILE A 1 198 ? 170.77300 322.50600 -1.41500  1.000 50.99328  ? 233 ILE F CD1 1 
ATOM   1292 N N   . THR A 1 199 ? 173.11100 325.99800 -5.14300  1.000 51.62188  ? 234 THR F N   1 
ATOM   1293 C CA  . THR A 1 199 ? 174.24100 326.48400 -5.90800  1.000 54.81004  ? 234 THR F CA  1 
ATOM   1294 C C   . THR A 1 199 ? 174.32900 328.00000 -5.90000  1.000 55.17994  ? 234 THR F C   1 
ATOM   1295 O O   . THR A 1 199 ? 175.43100 328.53900 -5.76200  1.000 59.99840  ? 234 THR F O   1 
ATOM   1296 C CB  . THR A 1 199 ? 174.11600 325.99800 -7.36000  1.000 56.30561  ? 234 THR F CB  1 
ATOM   1297 O OG1 . THR A 1 199 ? 174.30500 324.57800 -7.40900  1.000 60.64338  ? 234 THR F OG1 1 
ATOM   1298 C CG2 . THR A 1 199 ? 175.12200 326.69200 -8.30000  1.000 50.16782  ? 234 THR F CG2 1 
ATOM   1299 N N   . ARG A 1 200 ? 173.19600 328.70700 -5.87800  1.000 53.77033  ? 235 ARG F N   1 
ATOM   1300 C CA  . ARG A 1 200 ? 173.28100 330.16600 -5.86200  1.000 53.38276  ? 235 ARG F CA  1 
ATOM   1301 C C   . ARG A 1 200 ? 173.89000 330.65900 -4.55100  1.000 57.07086  ? 235 ARG F C   1 
ATOM   1302 O O   . ARG A 1 200 ? 174.79400 331.50600 -4.54800  1.000 62.47338  ? 235 ARG F O   1 
ATOM   1303 C CB  . ARG A 1 200 ? 171.91900 330.81000 -6.06300  1.000 56.89545  ? 235 ARG F CB  1 
ATOM   1304 C CG  . ARG A 1 200 ? 172.04200 332.22400 -6.61900  1.000 61.38920  ? 235 ARG F CG  1 
ATOM   1305 C CD  . ARG A 1 200 ? 170.69400 332.87700 -6.87800  1.000 58.65419  ? 235 ARG F CD  1 
ATOM   1306 N NE  . ARG A 1 200 ? 169.66600 331.91300 -7.24800  1.000 68.86924  ? 235 ARG F NE  1 
ATOM   1307 C CZ  . ARG A 1 200 ? 169.30600 331.54300 -8.47000  1.000 73.08938  ? 235 ARG F CZ  1 
ATOM   1308 N NH1 . ARG A 1 200 ? 169.89100 332.04200 -9.55300  1.000 72.10541  ? 235 ARG F NH1 1 
ATOM   1309 N NH2 . ARG A 1 200 ? 168.31100 330.66000 -8.60800  1.000 65.20927  ? 235 ARG F NH2 1 
ATOM   1310 N N   . GLU A 1 201 ? 173.43900 330.10300 -3.42000  1.000 55.23660  ? 236 GLU F N   1 
ATOM   1311 C CA  . GLU A 1 201 ? 173.96400 330.54300 -2.12900  1.000 55.56002  ? 236 GLU F CA  1 
ATOM   1312 C C   . GLU A 1 201 ? 175.42200 330.14400 -1.92600  1.000 61.13854  ? 236 GLU F C   1 
ATOM   1313 O O   . GLU A 1 201 ? 176.21100 330.94600 -1.41600  1.000 69.07327  ? 236 GLU F O   1 
ATOM   1314 C CB  . GLU A 1 201 ? 173.11300 329.99300 -0.98800  1.000 52.98042  ? 236 GLU F CB  1 
ATOM   1315 C CG  . GLU A 1 201 ? 171.65400 330.35400 -1.03700  1.000 54.88719  ? 236 GLU F CG  1 
ATOM   1316 C CD  . GLU A 1 201 ? 170.87800 329.82300 0.18300   1.000 64.79124  ? 236 GLU F CD  1 
ATOM   1317 O OE1 . GLU A 1 201 ? 171.50600 329.43500 1.21000   1.000 58.50840  ? 236 GLU F OE1 1 
ATOM   1318 O OE2 . GLU A 1 201 ? 169.62500 329.85300 0.13100   1.000 69.31792  ? 236 GLU F OE2 1 
ATOM   1319 N N   . PHE A 1 202 ? 175.81400 328.92500 -2.29300  1.000 57.14053  ? 237 PHE F N   1 
ATOM   1320 C CA  . PHE A 1 202 ? 177.21000 328.54500 -2.07800  1.000 54.72927  ? 237 PHE F CA  1 
ATOM   1321 C C   . PHE A 1 202 ? 178.15600 329.32700 -2.99500  1.000 63.36491  ? 237 PHE F C   1 
ATOM   1322 O O   . PHE A 1 202 ? 179.31500 329.56500 -2.63100  1.000 57.83602  ? 237 PHE F O   1 
ATOM   1323 C CB  . PHE A 1 202 ? 177.39700 327.04800 -2.28000  1.000 53.94394  ? 237 PHE F CB  1 
ATOM   1324 C CG  . PHE A 1 202 ? 177.12700 326.23300 -1.05800  1.000 54.54311  ? 237 PHE F CG  1 
ATOM   1325 C CD1 . PHE A 1 202 ? 177.33700 326.76200 0.19500   1.000 53.59690  ? 237 PHE F CD1 1 
ATOM   1326 C CD2 . PHE A 1 202 ? 176.67300 324.93500 -1.15900  1.000 56.25646  ? 237 PHE F CD2 1 
ATOM   1327 C CE1 . PHE A 1 202 ? 177.09100 326.01300 1.32300   1.000 53.21760  ? 237 PHE F CE1 1 
ATOM   1328 C CE2 . PHE A 1 202 ? 176.43600 324.17600 -0.03000  1.000 54.98651  ? 237 PHE F CE2 1 
ATOM   1329 C CZ  . PHE A 1 202 ? 176.64900 324.71400 1.20900   1.000 53.23085  ? 237 PHE F CZ  1 
ATOM   1330 N N   . SER A 1 203 ? 177.67400 329.75800 -4.17000  1.000 65.21096  ? 238 SER F N   1 
ATOM   1331 C CA  . SER A 1 203 ? 178.50800 330.48900 -5.11800  1.000 62.03456  ? 238 SER F CA  1 
ATOM   1332 C C   . SER A 1 203 ? 178.75200 331.92800 -4.70600  1.000 68.52232  ? 238 SER F C   1 
ATOM   1333 O O   . SER A 1 203 ? 179.89600 332.40000 -4.75700  1.000 76.90360  ? 238 SER F O   1 
ATOM   1334 C CB  . SER A 1 203 ? 177.86000 330.48100 -6.49800  1.000 60.63314  ? 238 SER F CB  1 
ATOM   1335 O OG  . SER A 1 203 ? 177.74700 329.15500 -6.96500  1.000 67.05006  ? 238 SER F OG  1 
ATOM   1336 N N   . VAL A 1 204 ? 177.71100 332.63300 -4.26000  1.000 68.57722  ? 239 VAL F N   1 
ATOM   1337 C CA  . VAL A 1 204 ? 177.88600 334.04400 -3.93000  1.000 72.65478  ? 239 VAL F CA  1 
ATOM   1338 C C   . VAL A 1 204 ? 178.65400 334.23000 -2.61500  1.000 64.84177  ? 239 VAL F C   1 
ATOM   1339 O O   . VAL A 1 204 ? 179.21000 335.30600 -2.37500  1.000 71.94373  ? 239 VAL F O   1 
ATOM   1340 C CB  . VAL A 1 204 ? 176.49700 334.72500 -3.88400  1.000 66.24453  ? 239 VAL F CB  1 
ATOM   1341 C CG1 . VAL A 1 204 ? 175.73300 334.30000 -2.63300  1.000 57.89592  ? 239 VAL F CG1 1 
ATOM   1342 C CG2 . VAL A 1 204 ? 176.60200 336.24600 -3.99600  1.000 67.07546  ? 239 VAL F CG2 1 
ATOM   1343 N N   . ASN A 1 205 ? 178.72100 333.20000 -1.77000  1.000 58.40338  ? 240 ASN F N   1 
ATOM   1344 C CA  . ASN A 1 205 ? 179.35100 333.27300 -0.45600  1.000 62.50917  ? 240 ASN F CA  1 
ATOM   1345 C C   . ASN A 1 205 ? 180.59000 332.38800 -0.31600  1.000 64.18566  ? 240 ASN F C   1 
ATOM   1346 O O   . ASN A 1 205 ? 180.95500 332.03400 0.80800   1.000 63.16631  ? 240 ASN F O   1 
ATOM   1347 C CB  . ASN A 1 205 ? 178.33300 332.92700 0.63500   1.000 64.63828  ? 240 ASN F CB  1 
ATOM   1348 C CG  . ASN A 1 205 ? 177.18200 333.93200 0.69500   1.000 72.14004  ? 240 ASN F CG  1 
ATOM   1349 O OD1 . ASN A 1 205 ? 177.39600 335.14800 0.66800   1.000 70.41925  ? 240 ASN F OD1 1 
ATOM   1350 N ND2 . ASN A 1 205 ? 175.95200 333.42400 0.75700   1.000 69.10124  ? 240 ASN F ND2 1 
ATOM   1351 N N   . ALA A 1 206 ? 181.19600 331.94100 -1.41500  1.000 62.84052  ? 241 ALA F N   1 
ATOM   1352 C CA  . ALA A 1 206 ? 182.45300 331.19500 -1.33600  1.000 59.77532  ? 241 ALA F CA  1 
ATOM   1353 C C   . ALA A 1 206 ? 182.37300 329.93600 -0.46000  1.000 59.41957  ? 241 ALA F C   1 
ATOM   1354 O O   . ALA A 1 206 ? 183.29200 329.62400 0.29800   1.000 59.16885  ? 241 ALA F O   1 
ATOM   1355 C CB  . ALA A 1 206 ? 183.58200 332.10200 -0.85100  1.000 63.73971  ? 241 ALA F CB  1 
ATOM   1356 N N   . GLY A 1 207 ? 181.28900 329.18000 -0.57300  1.000 59.80433  ? 242 GLY F N   1 
ATOM   1357 C CA  . GLY A 1 207 ? 181.19300 327.90700 0.13000   1.000 59.03598  ? 242 GLY F CA  1 
ATOM   1358 C C   . GLY A 1 207 ? 180.82000 327.92600 1.59600   1.000 57.81062  ? 242 GLY F C   1 
ATOM   1359 O O   . GLY A 1 207 ? 180.72300 326.84000 2.19600   1.000 54.96241  ? 242 GLY F O   1 
ATOM   1360 N N   . VAL A 1 208 ? 180.73100 329.09900 2.22400   1.000 65.03287  ? 243 VAL F N   1 
ATOM   1361 C CA  . VAL A 1 208 ? 180.36700 329.24400 3.63900   1.000 62.43073  ? 243 VAL F CA  1 
ATOM   1362 C C   . VAL A 1 208 ? 179.18700 330.20400 3.79300   1.000 61.69600  ? 243 VAL F C   1 
ATOM   1363 O O   . VAL A 1 208 ? 179.31800 331.39800 3.48800   1.000 63.57778  ? 243 VAL F O   1 
ATOM   1364 C CB  . VAL A 1 208 ? 181.54400 329.69700 4.50200   1.000 59.03719  ? 243 VAL F CB  1 
ATOM   1365 C CG1 . VAL A 1 208 ? 181.11900 329.69600 5.97400   1.000 59.26343  ? 243 VAL F CG1 1 
ATOM   1366 C CG2 . VAL A 1 208 ? 182.71800 328.76900 4.30300   1.000 58.22556  ? 243 VAL F CG2 1 
ATOM   1367 N N   . THR A 1 209 ? 178.01600 329.68100 4.16600   1.000 58.97474  ? 244 THR F N   1 
ATOM   1368 C CA  . THR A 1 209 ? 176.82000 330.50900 4.29000   1.000 57.82932  ? 244 THR F CA  1 
ATOM   1369 C C   . THR A 1 209 ? 176.37400 330.58400 5.74800   1.000 51.19834  ? 244 THR F C   1 
ATOM   1370 O O   . THR A 1 209 ? 176.51600 329.61900 6.50600   1.000 49.52109  ? 244 THR F O   1 
ATOM   1371 C CB  . THR A 1 209 ? 175.62900 329.95700 3.47000   1.000 54.36295  ? 244 THR F CB  1 
ATOM   1372 O OG1 . THR A 1 209 ? 175.13600 328.74700 4.07200   1.000 61.62239  ? 244 THR F OG1 1 
ATOM   1373 C CG2 . THR A 1 209 ? 175.99800 329.71200 2.01400   1.000 54.68002  ? 244 THR F CG2 1 
ATOM   1374 N N   . THR A 1 210 ? 175.90900 331.75200 6.16200   1.000 50.49454  ? 245 THR F N   1 
ATOM   1375 C CA  . THR A 1 210 ? 175.33200 331.84000 7.49800   1.000 43.40151  ? 245 THR F CA  1 
ATOM   1376 C C   . THR A 1 210 ? 174.45900 333.08000 7.42000   1.000 39.87465  ? 245 THR F C   1 
ATOM   1377 O O   . THR A 1 210 ? 174.94500 334.14200 7.01300   1.000 45.46888  ? 245 THR F O   1 
ATOM   1378 C CB  . THR A 1 210 ? 176.39900 331.94500 8.60800   1.000 48.23084  ? 245 THR F CB  1 
ATOM   1379 O OG1 . THR A 1 210 ? 175.76500 332.18000 9.87200   1.000 45.21753  ? 245 THR F OG1 1 
ATOM   1380 C CG2 . THR A 1 210 ? 177.38800 333.10400 8.34700   1.000 33.68300  ? 245 THR F CG2 1 
ATOM   1381 N N   . PRO A 1 211 ? 173.20100 333.02100 7.85800   1.000 39.90545  ? 246 PRO F N   1 
ATOM   1382 C CA  . PRO A 1 211 ? 172.57500 331.83700 8.45000   1.000 41.93327  ? 246 PRO F CA  1 
ATOM   1383 C C   . PRO A 1 211 ? 172.33400 330.70000 7.45900   1.000 42.51351  ? 246 PRO F C   1 
ATOM   1384 O O   . PRO A 1 211 ? 172.50400 330.83700 6.24300   1.000 45.09392  ? 246 PRO F O   1 
ATOM   1385 C CB  . PRO A 1 211 ? 171.19900 332.35900 8.90100   1.000 35.42636  ? 246 PRO F CB  1 
ATOM   1386 C CG  . PRO A 1 211 ? 171.30600 333.83500 8.88800   1.000 36.28576  ? 246 PRO F CG  1 
ATOM   1387 C CD  . PRO A 1 211 ? 172.25900 334.14900 7.78900   1.000 34.96937  ? 246 PRO F CD  1 
ATOM   1388 N N   . VAL A 1 212 ? 171.95700 329.55300 8.01300   1.000 40.14462  ? 247 VAL F N   1 
ATOM   1389 C CA  . VAL A 1 212 ? 171.65000 328.36400 7.22600   1.000 42.98426  ? 247 VAL F CA  1 
ATOM   1390 C C   . VAL A 1 212 ? 170.19300 328.48900 6.78000   1.000 42.48535  ? 247 VAL F C   1 
ATOM   1391 O O   . VAL A 1 212 ? 169.27600 328.45700 7.61000   1.000 40.96948  ? 247 VAL F O   1 
ATOM   1392 C CB  . VAL A 1 212 ? 171.89400 327.08500 8.03300   1.000 40.65035  ? 247 VAL F CB  1 
ATOM   1393 C CG1 . VAL A 1 212 ? 171.49600 325.86400 7.23900   1.000 42.13420  ? 247 VAL F CG1 1 
ATOM   1394 C CG2 . VAL A 1 212 ? 173.35200 327.00900 8.45600   1.000 37.10677  ? 247 VAL F CG2 1 
ATOM   1395 N N   . SER A 1 213 ? 169.97900 328.62900 5.47100   1.000 42.26524  ? 248 SER F N   1 
ATOM   1396 C CA  . SER A 1 213 ? 168.65700 328.83300 4.90100   1.000 41.52447  ? 248 SER F CA  1 
ATOM   1397 C C   . SER A 1 213 ? 167.84300 327.53800 4.87500   1.000 48.65339  ? 248 SER F C   1 
ATOM   1398 O O   . SER A 1 213 ? 168.34800 326.43900 5.14800   1.000 43.23815  ? 248 SER F O   1 
ATOM   1399 C CB  . SER A 1 213 ? 168.78300 329.35800 3.48300   1.000 40.07882  ? 248 SER F CB  1 
ATOM   1400 O OG  . SER A 1 213 ? 169.44100 328.39200 2.70100   1.000 44.04369  ? 248 SER F OG  1 
ATOM   1401 N N   . THR A 1 214 ? 166.53700 327.68500 4.58800   1.000 49.61788  ? 249 THR F N   1 
ATOM   1402 C CA  . THR A 1 214 ? 165.68100 326.50500 4.42600   1.000 52.08117  ? 249 THR F CA  1 
ATOM   1403 C C   . THR A 1 214 ? 166.04800 325.69300 3.17500   1.000 54.33984  ? 249 THR F C   1 
ATOM   1404 O O   . THR A 1 214 ? 165.65600 324.52200 3.07700   1.000 49.82017  ? 249 THR F O   1 
ATOM   1405 C CB  . THR A 1 214 ? 164.21400 326.90500 4.42400   1.000 49.68842  ? 249 THR F CB  1 
ATOM   1406 O OG1 . THR A 1 214 ? 163.98100 327.84700 3.36400   1.000 65.81349  ? 249 THR F OG1 1 
ATOM   1407 C CG2 . THR A 1 214 ? 163.82900 327.49500 5.76200   1.000 48.54557  ? 249 THR F CG2 1 
ATOM   1408 N N   . TYR A 1 215 ? 166.74400 326.29800 2.19700   1.000 49.31225  ? 250 TYR F N   1 
ATOM   1409 C CA  . TYR A 1 215 ? 167.26000 325.52600 1.06800   1.000 47.56215  ? 250 TYR F CA  1 
ATOM   1410 C C   . TYR A 1 215 ? 168.39600 324.61600 1.50300   1.000 52.26902  ? 250 TYR F C   1 
ATOM   1411 O O   . TYR A 1 215 ? 168.47100 323.46300 1.06900   1.000 53.23787  ? 250 TYR F O   1 
ATOM   1412 C CB  . TYR A 1 215 ? 167.74900 326.44100 -0.05100  1.000 50.03455  ? 250 TYR F CB  1 
ATOM   1413 C CG  . TYR A 1 215 ? 166.66000 327.18000 -0.77500  1.000 60.13381  ? 250 TYR F CG  1 
ATOM   1414 C CD1 . TYR A 1 215 ? 165.41600 326.60000 -0.99200  1.000 59.80289  ? 250 TYR F CD1 1 
ATOM   1415 C CD2 . TYR A 1 215 ? 166.85100 328.48900 -1.17400  1.000 59.41185  ? 250 TYR F CD2 1 
ATOM   1416 C CE1 . TYR A 1 215 ? 164.41800 327.29700 -1.63300  1.000 61.63144  ? 250 TYR F CE1 1 
ATOM   1417 C CE2 . TYR A 1 215 ? 165.86600 329.18700 -1.80800  1.000 62.02146  ? 250 TYR F CE2 1 
ATOM   1418 C CZ  . TYR A 1 215 ? 164.64900 328.59800 -2.03500  1.000 63.95130  ? 250 TYR F CZ  1 
ATOM   1419 O OH  . TYR A 1 215 ? 163.67200 329.32800 -2.67900  1.000 63.47358  ? 250 TYR F OH  1 
ATOM   1420 N N   . MET A 1 216 ? 169.29600 325.11500 2.35900   1.000 54.81628  ? 251 MET F N   1 
ATOM   1421 C CA  . MET A 1 216 ? 170.36100 324.26100 2.88000   1.000 49.03151  ? 251 MET F CA  1 
ATOM   1422 C C   . MET A 1 216 ? 169.79400 323.17700 3.77800   1.000 50.17046  ? 251 MET F C   1 
ATOM   1423 O O   . MET A 1 216 ? 170.24800 322.02900 3.74200   1.000 55.56292  ? 251 MET F O   1 
ATOM   1424 C CB  . MET A 1 216 ? 171.36800 325.10400 3.65700   1.000 47.83355  ? 251 MET F CB  1 
ATOM   1425 C CG  . MET A 1 216 ? 172.06600 326.06800 2.74400   1.000 54.77735  ? 251 MET F CG  1 
ATOM   1426 S SD  . MET A 1 216 ? 173.27700 325.25300 1.73100   1.000 52.11456  ? 251 MET F SD  1 
ATOM   1427 C CE  . MET A 1 216 ? 173.81300 326.56200 0.63300   1.000 42.18452  ? 251 MET F CE  1 
ATOM   1428 N N   . LEU A 1 217 ? 168.80300 323.51900 4.59800   1.000 48.76432  ? 252 LEU F N   1 
ATOM   1429 C CA  . LEU A 1 217 ? 168.25300 322.54400 5.53200   1.000 51.96521  ? 252 LEU F CA  1 
ATOM   1430 C C   . LEU A 1 217 ? 166.81300 322.93200 5.87800   1.000 52.15817  ? 252 LEU F C   1 
ATOM   1431 O O   . LEU A 1 217 ? 166.59100 323.92300 6.57400   1.000 51.69404  ? 252 LEU F O   1 
ATOM   1432 C CB  . LEU A 1 217 ? 169.15500 322.52000 6.75700   1.000 52.68722  ? 252 LEU F CB  1 
ATOM   1433 C CG  . LEU A 1 217 ? 169.16800 321.39100 7.74600   1.000 56.92693  ? 252 LEU F CG  1 
ATOM   1434 C CD1 . LEU A 1 217 ? 169.63200 320.18800 6.94500   1.000 51.33599  ? 252 LEU F CD1 1 
ATOM   1435 C CD2 . LEU A 1 217 ? 170.13700 321.71300 8.87600   1.000 56.76708  ? 252 LEU F CD2 1 
ATOM   1436 N N   . THR A 1 218 ? 165.83500 322.13300 5.47600   1.000 56.48868  ? 253 THR F N   1 
ATOM   1437 C CA  . THR A 1 218 ? 164.45900 322.50400 5.78800   1.000 59.58861  ? 253 THR F CA  1 
ATOM   1438 C C   . THR A 1 218 ? 164.20200 322.42700 7.29200   1.000 52.41707  ? 253 THR F C   1 
ATOM   1439 O O   . THR A 1 218 ? 164.82500 321.65800 8.01700   1.000 54.41998  ? 253 THR F O   1 
ATOM   1440 C CB  . THR A 1 218 ? 163.46300 321.62000 5.02600   1.000 59.19666  ? 253 THR F CB  1 
ATOM   1441 O OG1 . THR A 1 218 ? 163.36000 320.32900 5.65600   1.000 61.63024  ? 253 THR F OG1 1 
ATOM   1442 C CG2 . THR A 1 218 ? 163.90900 321.44500 3.58200   1.000 56.25545  ? 253 THR F CG2 1 
ATOM   1443 N N   . ASN A 1 219 ? 163.21800 323.18800 7.75400   1.000 50.82687  ? 254 ASN F N   1 
ATOM   1444 C CA  . ASN A 1 219 ? 162.87100 323.10400 9.16800   1.000 56.40038  ? 254 ASN F CA  1 
ATOM   1445 C C   . ASN A 1 219 ? 162.53900 321.68400 9.57700   1.000 60.57239  ? 254 ASN F C   1 
ATOM   1446 O O   . ASN A 1 219 ? 162.83400 321.27400 10.70300  1.000 62.71356  ? 254 ASN F O   1 
ATOM   1447 C CB  . ASN A 1 219 ? 161.69900 324.02100 9.50200   1.000 54.33229  ? 254 ASN F CB  1 
ATOM   1448 C CG  . ASN A 1 219 ? 162.06400 325.46000 9.43600   1.000 62.74285  ? 254 ASN F CG  1 
ATOM   1449 O OD1 . ASN A 1 219 ? 163.09000 325.82800 8.86700   1.000 68.43520  ? 254 ASN F OD1 1 
ATOM   1450 N ND2 . ASN A 1 219 ? 161.23100 326.30200 10.03200  1.000 67.75394  ? 254 ASN F ND2 1 
ATOM   1451 N N   . SER A 1 220 ? 161.88800 320.93000 8.69700   1.000 66.54616  ? 255 SER F N   1 
ATOM   1452 C CA  . SER A 1 220 ? 161.62000 319.53200 9.00400   1.000 61.15822  ? 255 SER F CA  1 
ATOM   1453 C C   . SER A 1 220 ? 162.92400 318.74900 9.13300   1.000 56.96491  ? 255 SER F C   1 
ATOM   1454 O O   . SER A 1 220 ? 163.06300 317.91000 10.03000  1.000 56.46518  ? 255 SER F O   1 
ATOM   1455 C CB  . SER A 1 220 ? 160.69700 318.94100 7.93100   1.000 64.95335  ? 255 SER F CB  1 
ATOM   1456 O OG  . SER A 1 220 ? 160.50500 317.54500 8.08300   1.000 65.52560  ? 255 SER F OG  1 
ATOM   1457 N N   . GLU A 1 221 ? 163.89600 319.00600 8.24800   1.000 58.72893  ? 256 GLU F N   1 
ATOM   1458 C CA  . GLU A 1 221 ? 165.17600 318.30000 8.33800   1.000 61.04770  ? 256 GLU F CA  1 
ATOM   1459 C C   . GLU A 1 221 ? 166.00600 318.75300 9.53600   1.000 59.99880  ? 256 GLU F C   1 
ATOM   1460 O O   . GLU A 1 221 ? 166.73000 317.94300 10.12800  1.000 59.66282  ? 256 GLU F O   1 
ATOM   1461 C CB  . GLU A 1 221 ? 165.98100 318.51200 7.05100   1.000 55.04578  ? 256 GLU F CB  1 
ATOM   1462 C CG  . GLU A 1 221 ? 165.23600 318.16900 5.77200   1.000 61.43605  ? 256 GLU F CG  1 
ATOM   1463 C CD  . GLU A 1 221 ? 165.94500 318.64700 4.50500   1.000 64.10091  ? 256 GLU F CD  1 
ATOM   1464 O OE1 . GLU A 1 221 ? 166.90700 319.43500 4.62000   1.000 61.97140  ? 256 GLU F OE1 1 
ATOM   1465 O OE2 . GLU A 1 221 ? 165.57400 318.18300 3.39500   1.000 63.58371  ? 256 GLU F OE2 1 
ATOM   1466 N N   . LEU A 1 222 ? 165.90400 320.03300 9.90800   1.000 58.08152  ? 257 LEU F N   1 
ATOM   1467 C CA  . LEU A 1 222 ? 166.66600 320.56400 11.03000  1.000 49.54853  ? 257 LEU F CA  1 
ATOM   1468 C C   . LEU A 1 222 ? 166.16600 320.01200 12.35400  1.000 53.73344  ? 257 LEU F C   1 
ATOM   1469 O O   . LEU A 1 222 ? 166.96800 319.63200 13.21000  1.000 62.95316  ? 257 LEU F O   1 
ATOM   1470 C CB  . LEU A 1 222 ? 166.61500 322.09100 11.03800  1.000 51.80813  ? 257 LEU F CB  1 
ATOM   1471 C CG  . LEU A 1 222 ? 167.33700 322.79500 12.19800  1.000 52.92105  ? 257 LEU F CG  1 
ATOM   1472 C CD1 . LEU A 1 222 ? 168.82600 322.45800 12.24800  1.000 45.53489  ? 257 LEU F CD1 1 
ATOM   1473 C CD2 . LEU A 1 222 ? 167.10200 324.31200 12.16800  1.000 41.41147  ? 257 LEU F CD2 1 
ATOM   1474 N N   . LEU A 1 223 ? 164.84200 319.98200 12.55700  1.000 48.77069  ? 258 LEU F N   1 
ATOM   1475 C CA  . LEU A 1 223 ? 164.31000 319.45800 13.81500  1.000 54.30876  ? 258 LEU F CA  1 
ATOM   1476 C C   . LEU A 1 223 ? 164.61500 317.97200 14.00900  1.000 62.38842  ? 258 LEU F C   1 
ATOM   1477 O O   . LEU A 1 223 ? 164.95700 317.55200 15.12400  1.000 62.58861  ? 258 LEU F O   1 
ATOM   1478 C CB  . LEU A 1 223 ? 162.80600 319.69800 13.89000  1.000 52.09112  ? 258 LEU F CB  1 
ATOM   1479 C CG  . LEU A 1 223 ? 162.32500 321.13600 14.03800  1.000 58.50507  ? 258 LEU F CG  1 
ATOM   1480 C CD1 . LEU A 1 223 ? 160.81500 321.17900 13.97700  1.000 52.90885  ? 258 LEU F CD1 1 
ATOM   1481 C CD2 . LEU A 1 223 ? 162.82500 321.73400 15.34900  1.000 59.96017  ? 258 LEU F CD2 1 
ATOM   1482 N N   . SER A 1 224 ? 164.51100 317.16100 12.94000  1.000 66.03511  ? 259 SER F N   1 
ATOM   1483 C CA  . SER A 1 224 ? 164.89500 315.74600 13.02300  1.000 70.46846  ? 259 SER F CA  1 
ATOM   1484 C C   . SER A 1 224 ? 166.39000 315.61400 13.26900  1.000 70.94609  ? 259 SER F C   1 
ATOM   1485 O O   . SER A 1 224 ? 166.83300 314.65900 13.91800  1.000 77.09495  ? 259 SER F O   1 
ATOM   1486 C CB  . SER A 1 224 ? 164.42100 314.96300 11.80300  1.000 73.16456  ? 259 SER F CB  1 
ATOM   1487 O OG  . SER A 1 224 ? 163.00900 315.06800 11.71600  1.000 82.88034  ? 259 SER F OG  1 
ATOM   1488 N N   . LEU A 1 225 ? 167.17700 316.55800 12.75500  1.000 62.68329  ? 260 LEU F N   1 
ATOM   1489 C CA  . LEU A 1 225 ? 168.60300 316.52900 13.03300  1.000 62.91449  ? 260 LEU F CA  1 
ATOM   1490 C C   . LEU A 1 225 ? 168.88400 316.89300 14.47500  1.000 66.54904  ? 260 LEU F C   1 
ATOM   1491 O O   . LEU A 1 225 ? 169.75800 316.28700 15.09600  1.000 71.49903  ? 260 LEU F O   1 
ATOM   1492 C CB  . LEU A 1 225 ? 169.32200 317.50100 12.11700  1.000 57.02215  ? 260 LEU F CB  1 
ATOM   1493 C CG  . LEU A 1 225 ? 170.83000 317.57000 12.29200  1.000 58.01909  ? 260 LEU F CG  1 
ATOM   1494 C CD1 . LEU A 1 225 ? 171.59100 316.30800 12.34700  1.000 67.90239  ? 260 LEU F CD1 1 
ATOM   1495 C CD2 . LEU A 1 225 ? 171.32300 318.41600 11.10700  1.000 55.57751  ? 260 LEU F CD2 1 
ATOM   1496 N N   . ILE A 1 226 ? 168.11100 317.81600 15.04500  1.000 67.37748  ? 261 ILE F N   1 
ATOM   1497 C CA  . ILE A 1 226 ? 168.29000 318.14100 16.45100  1.000 66.34905  ? 261 ILE F CA  1 
ATOM   1498 C C   . ILE A 1 226 ? 167.91000 316.94100 17.30000  1.000 68.49155  ? 261 ILE F C   1 
ATOM   1499 O O   . ILE A 1 226 ? 168.54300 316.65800 18.32100  1.000 68.21336  ? 261 ILE F O   1 
ATOM   1500 C CB  . ILE A 1 226 ? 167.47600 319.38500 16.83300  1.000 59.46113  ? 261 ILE F CB  1 
ATOM   1501 C CG1 . ILE A 1 226 ? 168.04500 320.62400 16.13700  1.000 50.53698  ? 261 ILE F CG1 1 
ATOM   1502 C CG2 . ILE A 1 226 ? 167.41100 319.51400 18.35100  1.000 51.89001  ? 261 ILE F CG2 1 
ATOM   1503 C CD1 . ILE A 1 226 ? 167.51600 321.90500 16.68400  1.000 44.79097  ? 261 ILE F CD1 1 
ATOM   1504 N N   . ASN A 1 227 ? 166.82400 316.26000 16.92800  1.000 69.83859  ? 262 ASN F N   1 
ATOM   1505 C CA  . ASN A 1 227 ? 166.33600 315.14900 17.73500  1.000 70.46812  ? 262 ASN F CA  1 
ATOM   1506 C C   . ASN A 1 227 ? 167.32900 314.00300 17.76100  1.000 69.82599  ? 262 ASN F C   1 
ATOM   1507 O O   . ASN A 1 227 ? 167.28800 313.18700 18.68200  1.000 75.35908  ? 262 ASN F O   1 
ATOM   1508 C CB  . ASN A 1 227 ? 164.96900 314.64800 17.26800  1.000 71.67444  ? 262 ASN F CB  1 
ATOM   1509 C CG  . ASN A 1 227 ? 163.89300 314.77400 18.35200  1.000 71.95199  ? 262 ASN F CG  1 
ATOM   1510 O OD1 . ASN A 1 227 ? 163.92300 315.68900 19.18400  1.000 75.84406  ? 262 ASN F OD1 1 
ATOM   1511 N ND2 . ASN A 1 227 ? 162.94700 313.83600 18.35500  1.000 70.36247  ? 262 ASN F ND2 1 
ATOM   1512 N N   . ASP A 1 228 ? 168.17500 313.87200 16.74100  1.000 76.55904  ? 263 ASP F N   1 
ATOM   1513 C CA  . ASP A 1 228 ? 169.05400 312.71600 16.69300  1.000 78.89867  ? 263 ASP F CA  1 
ATOM   1514 C C   . ASP A 1 228 ? 170.44200 312.96100 17.30800  1.000 80.95183  ? 263 ASP F C   1 
ATOM   1515 O O   . ASP A 1 228 ? 171.33700 312.13100 17.12600  1.000 86.66760  ? 263 ASP F O   1 
ATOM   1516 C CB  . ASP A 1 228 ? 169.17500 312.27700 15.23400  1.000 81.10650  ? 263 ASP F CB  1 
ATOM   1517 C CG  . ASP A 1 228 ? 168.07500 311.30400 14.83600  1.000 89.44980  ? 263 ASP F CG  1 
ATOM   1518 O OD1 . ASP A 1 228 ? 167.36300 310.80700 15.73400  1.000 94.02998  ? 263 ASP F OD1 1 
ATOM   1519 O OD2 . ASP A 1 228 ? 167.88000 311.09100 13.61800  1.000 90.87318  ? 263 ASP F OD2 1 
ATOM   1520 N N   . MET A 1 229 ? 170.67100 314.18900 18.05700  1.000 75.31886  ? 264 MET F N   1 
ATOM   1521 C CA  . MET A 1 229 ? 171.87400 314.71200 18.70100  1.000 78.72399  ? 264 MET F CA  1 
ATOM   1522 C C   . MET A 1 229 ? 172.04400 314.19900 20.12900  1.000 84.17338  ? 264 MET F C   1 
ATOM   1523 O O   . MET A 1 229 ? 171.05500 313.96500 20.84100  1.000 81.73234  ? 264 MET F O   1 
ATOM   1524 C CB  . MET A 1 229 ? 171.92600 316.23800 18.68800  1.000 77.20533  ? 264 MET F CB  1 
ATOM   1525 C CG  . MET A 1 229 ? 172.39200 316.82800 17.36000  1.000 70.05811  ? 264 MET F CG  1 
ATOM   1526 S SD  . MET A 1 229 ? 171.80700 318.49600 16.97600  1.000 79.26726  ? 264 MET F SD  1 
ATOM   1527 C CE  . MET A 1 229 ? 172.29900 319.49900 18.38100  1.000 64.85966  ? 264 MET F CE  1 
ATOM   1528 N N   . PRO A 1 230 ? 173.31900 314.08400 20.54300  1.000 90.05812  ? 265 PRO F N   1 
ATOM   1529 C CA  . PRO A 1 230 ? 173.70700 313.70400 21.91400  1.000 77.92761  ? 265 PRO F CA  1 
ATOM   1530 C C   . PRO A 1 230 ? 173.57500 314.85800 22.90700  1.000 68.81277  ? 265 PRO F C   1 
ATOM   1531 O O   . PRO A 1 230 ? 174.56200 315.35700 23.46100  1.000 78.42892  ? 265 PRO F O   1 
ATOM   1532 C CB  . PRO A 1 230 ? 175.16300 313.26300 21.72500  1.000 71.35077  ? 265 PRO F CB  1 
ATOM   1533 C CG  . PRO A 1 230 ? 175.65300 314.10000 20.60000  1.000 75.63549  ? 265 PRO F CG  1 
ATOM   1534 C CD  . PRO A 1 230 ? 174.49000 314.25000 19.65900  1.000 84.47315  ? 265 PRO F CD  1 
ATOM   1535 N N   . ILE A 1 231 ? 172.35900 315.37600 23.06300  1.000 61.95319  ? 266 ILE F N   1 
ATOM   1536 C CA  . ILE A 1 231 ? 172.11500 316.46000 24.01100  1.000 72.87154  ? 266 ILE F CA  1 
ATOM   1537 C C   . ILE A 1 231 ? 170.94300 316.08900 24.91000  1.000 69.80362  ? 266 ILE F C   1 
ATOM   1538 O O   . ILE A 1 231 ? 170.16100 315.18600 24.61600  1.000 67.90096  ? 266 ILE F O   1 
ATOM   1539 C CB  . ILE A 1 231 ? 171.90400 317.84600 23.34100  1.000 78.01643  ? 266 ILE F CB  1 
ATOM   1540 C CG1 . ILE A 1 231 ? 170.81500 317.79600 22.26700  1.000 77.65600  ? 266 ILE F CG1 1 
ATOM   1541 C CG2 . ILE A 1 231 ? 173.22900 318.39500 22.78000  1.000 73.63492  ? 266 ILE F CG2 1 
ATOM   1542 C CD1 . ILE A 1 231 ? 170.53600 319.16400 21.63200  1.000 67.15686  ? 266 ILE F CD1 1 
ATOM   1543 N N   . THR A 1 232 ? 170.79800 316.84800 25.98700  1.000 66.00387  ? 267 THR F N   1 
ATOM   1544 C CA  . THR A 1 232 ? 169.77000 316.53600 26.95800  1.000 69.73860  ? 267 THR F CA  1 
ATOM   1545 C C   . THR A 1 232 ? 168.39600 316.76000 26.36200  1.000 69.07545  ? 267 THR F C   1 
ATOM   1546 O O   . THR A 1 232 ? 168.23300 317.44100 25.35300  1.000 72.41634  ? 267 THR F O   1 
ATOM   1547 C CB  . THR A 1 232 ? 169.92700 317.40900 28.19400  1.000 71.82127  ? 267 THR F CB  1 
ATOM   1548 O OG1 . THR A 1 232 ? 171.31900 317.63700 28.42400  1.000 74.71817  ? 267 THR F OG1 1 
ATOM   1549 C CG2 . THR A 1 232 ? 169.32700 316.71400 29.41500  1.000 75.74604  ? 267 THR F CG2 1 
ATOM   1550 N N   . ASN A 1 233 ? 167.38900 316.17000 26.99800  1.000 73.97330  ? 268 ASN F N   1 
ATOM   1551 C CA  . ASN A 1 233 ? 166.04800 316.41300 26.49600  1.000 74.43478  ? 268 ASN F CA  1 
ATOM   1552 C C   . ASN A 1 233 ? 165.66400 317.86900 26.68200  1.000 76.24260  ? 268 ASN F C   1 
ATOM   1553 O O   . ASN A 1 233 ? 164.93500 318.42600 25.85200  1.000 76.25903  ? 268 ASN F O   1 
ATOM   1554 C CB  . ASN A 1 233 ? 165.02500 315.52400 27.21000  1.000 73.14909  ? 268 ASN F CB  1 
ATOM   1555 C CG  . ASN A 1 233 ? 164.89500 314.14900 26.57300  1.000 76.28981  ? 268 ASN F CG  1 
ATOM   1556 O OD1 . ASN A 1 233 ? 164.40100 314.01100 25.44700  1.000 72.71471  ? 268 ASN F OD1 1 
ATOM   1557 N ND2 . ASN A 1 233 ? 165.28600 313.11200 27.32500  1.000 72.87531  ? 268 ASN F ND2 1 
ATOM   1558 N N   . ASP A 1 234 ? 166.16000 318.50700 27.74900  1.000 81.32839  ? 269 ASP F N   1 
ATOM   1559 C CA  . ASP A 1 234 ? 165.94500 319.94000 27.93500  1.000 79.22684  ? 269 ASP F CA  1 
ATOM   1560 C C   . ASP A 1 234 ? 166.71400 320.79300 26.92600  1.000 72.06085  ? 269 ASP F C   1 
ATOM   1561 O O   . ASP A 1 234 ? 166.30100 321.92300 26.64600  1.000 67.88774  ? 269 ASP F O   1 
ATOM   1562 C CB  . ASP A 1 234 ? 166.28700 320.35300 29.37100  1.000 81.67656  ? 269 ASP F CB  1 
ATOM   1563 C CG  . ASP A 1 234 ? 165.36400 321.46200 29.89200  1.000 90.30333  ? 269 ASP F CG  1 
ATOM   1564 O OD1 . ASP A 1 234 ? 164.94300 322.32800 29.08600  1.000 83.78544  ? 269 ASP F OD1 1 
ATOM   1565 O OD2 . ASP A 1 234 ? 165.05500 321.46600 31.10600  1.000 93.09073  ? 269 ASP F OD2 1 
ATOM   1566 N N   . GLN A 1 235 ? 167.81400 320.28800 26.37300  1.000 67.61042  ? 270 GLN F N   1 
ATOM   1567 C CA  . GLN A 1 235 ? 168.55700 321.08200 25.40600  1.000 62.86338  ? 270 GLN F CA  1 
ATOM   1568 C C   . GLN A 1 235 ? 167.95400 320.94500 24.01200  1.000 65.28098  ? 270 GLN F C   1 
ATOM   1569 O O   . GLN A 1 235 ? 168.03600 321.88400 23.21200  1.000 66.49504  ? 270 GLN F O   1 
ATOM   1570 C CB  . GLN A 1 235 ? 170.03500 320.71600 25.45300  1.000 66.89284  ? 270 GLN F CB  1 
ATOM   1571 C CG  . GLN A 1 235 ? 170.90400 321.66500 24.67900  1.000 68.52942  ? 270 GLN F CG  1 
ATOM   1572 C CD  . GLN A 1 235 ? 172.36600 321.45900 24.98300  1.000 65.43247  ? 270 GLN F CD  1 
ATOM   1573 O OE1 . GLN A 1 235 ? 172.72300 320.64000 25.83300  1.000 63.53180  ? 270 GLN F OE1 1 
ATOM   1574 N NE2 . GLN A 1 235 ? 173.22400 322.21500 24.30500  1.000 58.48190  ? 270 GLN F NE2 1 
ATOM   1575 N N   . LYS A 1 236 ? 167.34000 319.79800 23.70500  1.000 66.66040  ? 271 LYS F N   1 
ATOM   1576 C CA  . LYS A 1 236 ? 166.65700 319.66700 22.42300  1.000 62.75172  ? 271 LYS F CA  1 
ATOM   1577 C C   . LYS A 1 236 ? 165.43100 320.57900 22.40000  1.000 56.38976  ? 271 LYS F C   1 
ATOM   1578 O O   . LYS A 1 236 ? 165.11700 321.19100 21.37400  1.000 58.31122  ? 271 LYS F O   1 
ATOM   1579 C CB  . LYS A 1 236 ? 166.23000 318.21100 22.17900  1.000 63.95894  ? 271 LYS F CB  1 
ATOM   1580 C CG  . LYS A 1 236 ? 167.36200 317.20400 22.03600  1.000 67.83038  ? 271 LYS F CG  1 
ATOM   1581 C CD  . LYS A 1 236 ? 166.85600 315.76800 21.82300  1.000 64.12756  ? 271 LYS F CD  1 
ATOM   1582 C CE  . LYS A 1 236 ? 168.04300 314.79500 21.72200  1.000 70.70838  ? 271 LYS F CE  1 
ATOM   1583 N NZ  . LYS A 1 236 ? 167.70000 313.35000 21.53300  1.000 63.84180  ? 271 LYS F NZ  1 
ATOM   1584 N N   . LYS A 1 237 ? 164.74300 320.70500 23.53300  1.000 53.61105  ? 272 LYS F N   1 
ATOM   1585 C CA  . LYS A 1 237 ? 163.61900 321.62700 23.60500  1.000 59.21661  ? 272 LYS F CA  1 
ATOM   1586 C C   . LYS A 1 237 ? 164.06300 323.06500 23.42200  1.000 59.86152  ? 272 LYS F C   1 
ATOM   1587 O O   . LYS A 1 237 ? 163.29600 323.88700 22.90400  1.000 57.38462  ? 272 LYS F O   1 
ATOM   1588 C CB  . LYS A 1 237 ? 162.88900 321.49300 24.94500  1.000 70.79288  ? 272 LYS F CB  1 
ATOM   1589 C CG  . LYS A 1 237 ? 162.20300 320.14800 25.19500  1.000 81.15510  ? 272 LYS F CG  1 
ATOM   1590 C CD  . LYS A 1 237 ? 160.70900 320.21900 24.83100  1.000 87.86962  ? 272 LYS F CD  1 
ATOM   1591 C CE  . LYS A 1 237 ? 160.00600 318.87400 25.03600  1.000 91.00113  ? 272 LYS F CE  1 
ATOM   1592 N NZ  . LYS A 1 237 ? 158.51500 319.00300 25.01700  1.000 82.53038  ? 272 LYS F NZ  1 
ATOM   1593 N N   . LEU A 1 238 ? 165.29100 323.39500 23.83100  1.000 62.49635  ? 273 LEU F N   1 
ATOM   1594 C CA  . LEU A 1 238 ? 165.73500 324.77500 23.68500  1.000 55.97057  ? 273 LEU F CA  1 
ATOM   1595 C C   . LEU A 1 238 ? 165.98300 325.10200 22.23000  1.000 48.07007  ? 273 LEU F C   1 
ATOM   1596 O O   . LEU A 1 238 ? 165.51800 326.13200 21.72800  1.000 48.38345  ? 273 LEU F O   1 
ATOM   1597 C CB  . LEU A 1 238 ? 167.02600 325.00600 24.47600  1.000 54.81693  ? 273 LEU F CB  1 
ATOM   1598 C CG  . LEU A 1 238 ? 167.57800 326.44700 24.54700  1.000 51.70019  ? 273 LEU F CG  1 
ATOM   1599 C CD1 . LEU A 1 238 ? 166.63800 327.46700 25.26100  1.000 44.96521  ? 273 LEU F CD1 1 
ATOM   1600 C CD2 . LEU A 1 238 ? 169.02300 326.51400 25.06700  1.000 47.13301  ? 273 LEU F CD2 1 
ATOM   1601 N N   . MET A 1 239 ? 166.73400 324.24400 21.54400  1.000 45.68378  ? 274 MET F N   1 
ATOM   1602 C CA  . MET A 1 239 ? 167.02700 324.50200 20.14500  1.000 48.65670  ? 274 MET F CA  1 
ATOM   1603 C C   . MET A 1 239 ? 165.80400 324.33400 19.25000  1.000 49.04002  ? 274 MET F C   1 
ATOM   1604 O O   . MET A 1 239 ? 165.70100 324.98900 18.20400  1.000 47.83735  ? 274 MET F O   1 
ATOM   1605 C CB  . MET A 1 239 ? 168.13200 323.57100 19.64600  1.000 49.36518  ? 274 MET F CB  1 
ATOM   1606 C CG  . MET A 1 239 ? 169.43400 323.66400 20.40600  1.000 42.94041  ? 274 MET F CG  1 
ATOM   1607 S SD  . MET A 1 239 ? 170.74500 322.57000 19.80300  1.000 56.03061  ? 274 MET F SD  1 
ATOM   1608 C CE  . MET A 1 239 ? 170.99900 323.16600 18.14300  1.000 49.14935  ? 274 MET F CE  1 
ATOM   1609 N N   . SER A 1 240 ? 164.88000 323.45900 19.62400  1.000 47.64428  ? 275 SER F N   1 
ATOM   1610 C CA  . SER A 1 240 ? 163.72800 323.24700 18.76700  1.000 47.66811  ? 275 SER F CA  1 
ATOM   1611 C C   . SER A 1 240 ? 162.73800 324.39300 18.84500  1.000 53.45436  ? 275 SER F C   1 
ATOM   1612 O O   . SER A 1 240 ? 162.09600 324.72900 17.84300  1.000 57.76276  ? 275 SER F O   1 
ATOM   1613 C CB  . SER A 1 240 ? 163.06400 321.92500 19.13700  1.000 47.94737  ? 275 SER F CB  1 
ATOM   1614 O OG  . SER A 1 240 ? 163.97500 320.85100 18.96600  1.000 45.61604  ? 275 SER F OG  1 
ATOM   1615 N N   . ASN A 1 241 ? 162.69000 325.07700 19.97200  1.000 50.10174  ? 276 ASN F N   1 
ATOM   1616 C CA  . ASN A 1 241 ? 161.81800 326.22400 20.14900  1.000 48.55224  ? 276 ASN F CA  1 
ATOM   1617 C C   . ASN A 1 241 ? 162.43500 327.53000 19.67300  1.000 48.54468  ? 276 ASN F C   1 
ATOM   1618 O O   . ASN A 1 241 ? 161.75300 328.55700 19.68300  1.000 54.98120  ? 276 ASN F O   1 
ATOM   1619 C CB  . ASN A 1 241 ? 161.39200 326.28500 21.60600  1.000 55.46824  ? 276 ASN F CB  1 
ATOM   1620 C CG  . ASN A 1 241 ? 160.52500 325.08600 21.98200  1.000 59.44712  ? 276 ASN F CG  1 
ATOM   1621 O OD1 . ASN A 1 241 ? 160.67700 324.51400 23.05600  1.000 68.28814  ? 276 ASN F OD1 1 
ATOM   1622 N ND2 . ASN A 1 241 ? 159.63200 324.68900 21.08200  1.000 60.67916  ? 276 ASN F ND2 1 
ATOM   1623 N N   . ASN A 1 242 ? 163.71800 327.53000 19.32200  1.000 49.87198  ? 277 ASN F N   1 
ATOM   1624 C CA  . ASN A 1 242 ? 164.41900 328.70900 18.82400  1.000 45.49751  ? 277 ASN F CA  1 
ATOM   1625 C C   . ASN A 1 242 ? 165.18400 328.36700 17.55600  1.000 41.54664  ? 277 ASN F C   1 
ATOM   1626 O O   . ASN A 1 242 ? 166.37400 328.66900 17.43100  1.000 34.58999  ? 277 ASN F O   1 
ATOM   1627 C CB  . ASN A 1 242 ? 165.36900 329.25900 19.87900  1.000 39.17655  ? 277 ASN F CB  1 
ATOM   1628 C CG  . ASN A 1 242 ? 164.67300 329.58100 21.18700  1.000 43.17153  ? 277 ASN F CG  1 
ATOM   1629 O OD1 . ASN A 1 242 ? 164.13000 330.68100 21.35700  1.000 45.28494  ? 277 ASN F OD1 1 
ATOM   1630 N ND2 . ASN A 1 242 ? 164.71500 328.64400 22.13200  1.000 42.87443  ? 277 ASN F ND2 1 
ATOM   1631 N N   . VAL A 1 243 ? 164.47500 327.80500 16.55700  1.000 43.34594  ? 278 VAL F N   1 
ATOM   1632 C CA  . VAL A 1 243 ? 165.14500 327.35300 15.33500  1.000 38.73002  ? 278 VAL F CA  1 
ATOM   1633 C C   . VAL A 1 243 ? 165.70800 328.50200 14.53000  1.000 36.75331  ? 278 VAL F C   1 
ATOM   1634 O O   . VAL A 1 243 ? 166.74300 328.34600 13.87200  1.000 37.47918  ? 278 VAL F O   1 
ATOM   1635 C CB  . VAL A 1 243 ? 164.21000 326.51100 14.43300  1.000 39.11395  ? 278 VAL F CB  1 
ATOM   1636 C CG1 . VAL A 1 243 ? 163.82100 325.20300 15.09900  1.000 51.51822  ? 278 VAL F CG1 1 
ATOM   1637 C CG2 . VAL A 1 243 ? 162.97500 327.29400 14.03000  1.000 47.12482  ? 278 VAL F CG2 1 
ATOM   1638 N N   . GLN A 1 244 ? 165.06400 329.66200 14.54700  1.000 38.63287  ? 279 GLN F N   1 
ATOM   1639 C CA  . GLN A 1 244 ? 165.60600 330.76800 13.76400  1.000 43.08136  ? 279 GLN F CA  1 
ATOM   1640 C C   . GLN A 1 244 ? 166.91000 331.27100 14.36500  1.000 37.56351  ? 279 GLN F C   1 
ATOM   1641 O O   . GLN A 1 244 ? 167.87000 331.55800 13.63900  1.000 38.69177  ? 279 GLN F O   1 
ATOM   1642 C CB  . GLN A 1 244 ? 164.56800 331.89100 13.64400  1.000 51.43032  ? 279 GLN F CB  1 
ATOM   1643 C CG  . GLN A 1 244 ? 163.11600 331.36800 13.65200  1.000 59.75230  ? 279 GLN F CG  1 
ATOM   1644 C CD  . GLN A 1 244 ? 162.56300 331.14600 15.06500  1.000 63.77950  ? 279 GLN F CD  1 
ATOM   1645 O OE1 . GLN A 1 244 ? 163.30900 331.20300 16.05800  1.000 63.23190  ? 279 GLN F OE1 1 
ATOM   1646 N NE2 . GLN A 1 244 ? 161.27900 330.78100 15.14900  1.000 71.33779  ? 279 GLN F NE2 1 
ATOM   1647 N N   . ILE A 1 245 ? 166.99100 331.31000 15.69200  1.000 36.46269  ? 280 ILE F N   1 
ATOM   1648 C CA  . ILE A 1 245 ? 168.24500 331.69000 16.32700  1.000 36.24110  ? 280 ILE F CA  1 
ATOM   1649 C C   . ILE A 1 245 ? 169.31100 330.63100 16.07900  1.000 36.12584  ? 280 ILE F C   1 
ATOM   1650 O O   . ILE A 1 245 ? 170.45400 330.95500 15.74100  1.000 32.93692  ? 280 ILE F O   1 
ATOM   1651 C CB  . ILE A 1 245 ? 168.00100 331.89100 17.83500  1.000 33.04832  ? 280 ILE F CB  1 
ATOM   1652 C CG1 . ILE A 1 245 ? 167.09000 333.09000 18.09700  1.000 34.78062  ? 280 ILE F CG1 1 
ATOM   1653 C CG2 . ILE A 1 245 ? 169.30500 331.97500 18.56100  1.000 31.95940  ? 280 ILE F CG2 1 
ATOM   1654 C CD1 . ILE A 1 245 ? 166.85200 333.37900 19.55100  1.000 30.93670  ? 280 ILE F CD1 1 
ATOM   1655 N N   . VAL A 1 246 ? 168.92700 329.35300 16.09500  1.000 32.45832  ? 281 VAL F N   1 
ATOM   1656 C CA  . VAL A 1 246 ? 169.90000 328.31700 15.79000  1.000 28.72527  ? 281 VAL F CA  1 
ATOM   1657 C C   . VAL A 1 246 ? 170.40800 328.48200 14.36800  1.000 31.41270  ? 281 VAL F C   1 
ATOM   1658 O O   . VAL A 1 246 ? 171.61000 328.39600 14.10700  1.000 35.68480  ? 281 VAL F O   1 
ATOM   1659 C CB  . VAL A 1 246 ? 169.30300 326.93000 16.03700  1.000 36.33048  ? 281 VAL F CB  1 
ATOM   1660 C CG1 . VAL A 1 246 ? 170.24300 325.84100 15.48500  1.000 35.07487  ? 281 VAL F CG1 1 
ATOM   1661 C CG2 . VAL A 1 246 ? 169.02200 326.75500 17.52100  1.000 29.02469  ? 281 VAL F CG2 1 
ATOM   1662 N N   . ARG A 1 247 ? 169.51000 328.79700 13.43900  1.000 35.12799  ? 282 ARG F N   1 
ATOM   1663 C CA  . ARG A 1 247 ? 169.90900 329.01500 12.05200  1.000 33.58935  ? 282 ARG F CA  1 
ATOM   1664 C C   . ARG A 1 247 ? 170.88300 330.18000 11.94500  1.000 38.57385  ? 282 ARG F C   1 
ATOM   1665 O O   . ARG A 1 247 ? 171.82200 330.14900 11.13800  1.000 37.00741  ? 282 ARG F O   1 
ATOM   1666 C CB  . ARG A 1 247 ? 168.66700 329.30700 11.21800  1.000 37.19490  ? 282 ARG F CB  1 
ATOM   1667 C CG  . ARG A 1 247 ? 167.72000 328.10700 11.13300  1.000 46.78690  ? 282 ARG F CG  1 
ATOM   1668 C CD  . ARG A 1 247 ? 166.52000 328.37800 10.25200  1.000 45.91720  ? 282 ARG F CD  1 
ATOM   1669 N NE  . ARG A 1 247 ? 166.80800 327.78400 8.96200   1.000 42.67197  ? 282 ARG F NE  1 
ATOM   1670 C CZ  . ARG A 1 247 ? 166.48500 326.54300 8.64200   1.000 43.27379  ? 282 ARG F CZ  1 
ATOM   1671 N NH1 . ARG A 1 247 ? 165.86100 325.75700 9.49300   1.000 47.92428  ? 282 ARG F NH1 1 
ATOM   1672 N NH2 . ARG A 1 247 ? 166.84600 326.06300 7.45400   1.000 51.13468  ? 282 ARG F NH2 1 
ATOM   1673 N N   . GLN A 1 248 ? 170.61300 331.26400 12.67700  1.000 40.37211  ? 283 GLN F N   1 
ATOM   1674 C CA  . GLN A 1 248 ? 171.48800 332.42500 12.63200  1.000 38.07837  ? 283 GLN F CA  1 
ATOM   1675 C C   . GLN A 1 248 ? 172.84700 332.18000 13.27700  1.000 35.28929  ? 283 GLN F C   1 
ATOM   1676 O O   . GLN A 1 248 ? 173.81000 332.88200 12.94300  1.000 39.02920  ? 283 GLN F O   1 
ATOM   1677 C CB  . GLN A 1 248 ? 170.78700 333.63000 13.24800  1.000 36.73561  ? 283 GLN F CB  1 
ATOM   1678 C CG  . GLN A 1 248 ? 169.61600 334.03400 12.42700  1.000 39.72557  ? 283 GLN F CG  1 
ATOM   1679 C CD  . GLN A 1 248 ? 168.78800 335.11100 13.05600  1.000 44.31514  ? 283 GLN F CD  1 
ATOM   1680 O OE1 . GLN A 1 248 ? 168.99000 335.48000 14.21300  1.000 41.50011  ? 283 GLN F OE1 1 
ATOM   1681 N NE2 . GLN A 1 248 ? 167.88300 335.68000 12.26500  1.000 55.26517  ? 283 GLN F NE2 1 
ATOM   1682 N N   . GLN A 1 249 ? 172.97000 331.16000 14.12100  1.000 34.94378  ? 284 GLN F N   1 
ATOM   1683 C CA  . GLN A 1 249 ? 174.23500 330.80300 14.75500  1.000 37.44709  ? 284 GLN F CA  1 
ATOM   1684 C C   . GLN A 1 249 ? 174.79100 329.49700 14.20900  1.000 42.80067  ? 284 GLN F C   1 
ATOM   1685 O O   . GLN A 1 249 ? 175.45300 328.75200 14.93700  1.000 48.87564  ? 284 GLN F O   1 
ATOM   1686 C CB  . GLN A 1 249 ? 174.07100 330.72300 16.27500  1.000 34.42554  ? 284 GLN F CB  1 
ATOM   1687 C CG  . GLN A 1 249 ? 173.79000 332.10000 16.87900  1.000 34.43058  ? 284 GLN F CG  1 
ATOM   1688 C CD  . GLN A 1 249 ? 173.73500 332.11200 18.39100  1.000 36.14573  ? 284 GLN F CD  1 
ATOM   1689 O OE1 . GLN A 1 249 ? 173.63400 331.06400 19.03900  1.000 36.87660  ? 284 GLN F OE1 1 
ATOM   1690 N NE2 . GLN A 1 249 ? 173.81400 333.30900 18.96800  1.000 41.24602  ? 284 GLN F NE2 1 
ATOM   1691 N N   . SER A 1 250 ? 174.48400 329.18800 12.94100  1.000 41.40761  ? 285 SER F N   1 
ATOM   1692 C CA  . SER A 1 250 ? 174.96400 327.99000 12.27700  1.000 35.49851  ? 285 SER F CA  1 
ATOM   1693 C C   . SER A 1 250 ? 175.71300 328.37700 11.01700  1.000 38.61445  ? 285 SER F C   1 
ATOM   1694 O O   . SER A 1 250 ? 175.56500 329.48800 10.49300  1.000 38.03456  ? 285 SER F O   1 
ATOM   1695 C CB  . SER A 1 250 ? 173.81600 327.06500 11.89600  1.000 36.40358  ? 285 SER F CB  1 
ATOM   1696 O OG  . SER A 1 250 ? 173.10600 326.62300 13.03400  1.000 36.07100  ? 285 SER F OG  1 
ATOM   1697 N N   . TYR A 1 251 ? 176.47400 327.42000 10.50200  1.000 39.63321  ? 286 TYR F N   1 
ATOM   1698 C CA  . TYR A 1 251 ? 177.22500 327.60600 9.27100   1.000 43.83060  ? 286 TYR F CA  1 
ATOM   1699 C C   . TYR A 1 251 ? 176.97500 326.43800 8.32700   1.000 45.17012  ? 286 TYR F C   1 
ATOM   1700 O O   . TYR A 1 251 ? 176.76400 325.29700 8.75600   1.000 42.25670  ? 286 TYR F O   1 
ATOM   1701 C CB  . TYR A 1 251 ? 178.72700 327.71500 9.51100   1.000 43.77903  ? 286 TYR F CB  1 
ATOM   1702 C CG  . TYR A 1 251 ? 179.22100 329.00900 10.10200  1.000 43.89541  ? 286 TYR F CG  1 
ATOM   1703 C CD1 . TYR A 1 251 ? 179.49800 330.11100 9.30600   1.000 45.53831  ? 286 TYR F CD1 1 
ATOM   1704 C CD2 . TYR A 1 251 ? 179.49500 329.09600 11.46000  1.000 45.51401  ? 286 TYR F CD2 1 
ATOM   1705 C CE1 . TYR A 1 251 ? 179.98700 331.28300 9.86000   1.000 47.48899  ? 286 TYR F CE1 1 
ATOM   1706 C CE2 . TYR A 1 251 ? 179.98900 330.25800 12.01800  1.000 48.33122  ? 286 TYR F CE2 1 
ATOM   1707 C CZ  . TYR A 1 251 ? 180.23700 331.34100 11.22100  1.000 50.15822  ? 286 TYR F CZ  1 
ATOM   1708 O OH  . TYR A 1 251 ? 180.72500 332.48200 11.81100  1.000 60.06770  ? 286 TYR F OH  1 
ATOM   1709 N N   . SER A 1 252 ? 176.98200 326.73200 7.03600   1.000 52.36829  ? 287 SER F N   1 
ATOM   1710 C CA  . SER A 1 252 ? 176.91700 325.70000 6.00600   1.000 60.87894  ? 287 SER F CA  1 
ATOM   1711 C C   . SER A 1 252 ? 178.18100 325.77000 5.15200   1.000 57.40166  ? 287 SER F C   1 
ATOM   1712 O O   . SER A 1 252 ? 178.43100 326.78800 4.49000   1.000 54.04012  ? 287 SER F O   1 
ATOM   1713 C CB  . SER A 1 252 ? 175.66600 325.86400 5.14100   1.000 59.30386  ? 287 SER F CB  1 
ATOM   1714 O OG  . SER A 1 252 ? 175.58200 324.80500 4.20100   1.000 62.51707  ? 287 SER F OG  1 
ATOM   1715 N N   . ILE A 1 253 ? 178.96900 324.69300 5.17300   1.000 48.80650  ? 288 ILE F N   1 
ATOM   1716 C CA  . ILE A 1 253 ? 180.27500 324.63800 4.51300   1.000 59.63718  ? 288 ILE F CA  1 
ATOM   1717 C C   . ILE A 1 253 ? 180.25100 323.59600 3.39600   1.000 65.19239  ? 288 ILE F C   1 
ATOM   1718 O O   . ILE A 1 253 ? 179.89600 322.42500 3.61900   1.000 59.12263  ? 288 ILE F O   1 
ATOM   1719 C CB  . ILE A 1 253 ? 181.43500 324.37200 5.49600   1.000 59.48056  ? 288 ILE F CB  1 
ATOM   1720 C CG1 . ILE A 1 253 ? 181.34200 325.29200 6.72800   1.000 51.06675  ? 288 ILE F CG1 1 
ATOM   1721 C CG2 . ILE A 1 253 ? 182.78200 324.48200 4.77000   1.000 53.96663  ? 288 ILE F CG2 1 
ATOM   1722 C CD1 . ILE A 1 253 ? 181.11900 324.56800 8.03800   1.000 49.05733  ? 288 ILE F CD1 1 
ATOM   1723 N N   . MET A 1 254 ? 180.69600 324.01700 2.20900   1.000 57.91727  ? 289 MET F N   1 
ATOM   1724 C CA  . MET A 1 254 ? 180.73300 323.13400 1.05900   1.000 63.39305  ? 289 MET F CA  1 
ATOM   1725 C C   . MET A 1 254 ? 181.97500 322.23800 1.06100   1.000 68.96921  ? 289 MET F C   1 
ATOM   1726 O O   . MET A 1 254 ? 183.10600 322.72600 1.14900   1.000 74.06107  ? 289 MET F O   1 
ATOM   1727 C CB  . MET A 1 254 ? 180.71800 324.00600 -0.20000  1.000 69.12974  ? 289 MET F CB  1 
ATOM   1728 C CG  . MET A 1 254 ? 179.51000 323.81000 -1.09700  1.000 66.43350  ? 289 MET F CG  1 
ATOM   1729 S SD  . MET A 1 254 ? 179.58700 322.21200 -1.93100  1.000 69.72656  ? 289 MET F SD  1 
ATOM   1730 C CE  . MET A 1 254 ? 180.80000 322.56300 -3.21200  1.000 71.27953  ? 289 MET F CE  1 
ATOM   1731 N N   . CYS A 1 255 ? 181.74700 320.92500 0.88700   1.000 67.81972  ? 290 CYS F N   1 
ATOM   1732 C CA  . CYS A 1 255 ? 182.75400 319.85500 0.85400   1.000 74.05677  ? 290 CYS F CA  1 
ATOM   1733 C C   . CYS A 1 255 ? 183.18200 319.51500 -0.56900  1.000 82.24039  ? 290 CYS F C   1 
ATOM   1734 O O   . CYS A 1 255 ? 184.09800 320.14000 -1.10100  1.000 78.26069  ? 290 CYS F O   1 
ATOM   1735 C CB  . CYS A 1 255 ? 182.29500 318.57700 1.55800   1.000 73.97313  ? 290 CYS F CB  1 
ATOM   1736 S SG  . CYS A 1 255 ? 182.32900 318.61400 3.37500   1.000 94.68298  ? 290 CYS F SG  1 
ATOM   1737 N N   . ILE A 1 256 ? 182.68000 318.42200 -1.14000  1.000 83.87586  ? 291 ILE F N   1 
ATOM   1738 C CA  . ILE A 1 256 ? 183.19600 317.99300 -2.43000  1.000 86.44805  ? 291 ILE F CA  1 
ATOM   1739 C C   . ILE A 1 256 ? 182.08500 317.48300 -3.33300  1.000 83.46570  ? 291 ILE F C   1 
ATOM   1740 O O   . ILE A 1 256 ? 180.99700 317.13100 -2.86300  1.000 75.32017  ? 291 ILE F O   1 
ATOM   1741 C CB  . ILE A 1 256 ? 184.28200 316.90900 -2.23700  1.000 82.15520  ? 291 ILE F CB  1 
ATOM   1742 C CG1 . ILE A 1 256 ? 185.04400 316.72200 -3.55100  1.000 82.66741  ? 291 ILE F CG1 1 
ATOM   1743 C CG2 . ILE A 1 256 ? 183.68000 315.61600 -1.61800  1.000 70.54407  ? 291 ILE F CG2 1 
ATOM   1744 C CD1 . ILE A 1 256 ? 185.77500 317.99700 -4.01200  1.000 77.82176  ? 291 ILE F CD1 1 
ATOM   1745 N N   . ILE A 1 257 ? 182.32400 317.56200 -4.65100  1.000 88.43362  ? 292 ILE F N   1 
ATOM   1746 C CA  . ILE A 1 257 ? 181.47200 316.89500 -5.63200  1.000 84.43566  ? 292 ILE F CA  1 
ATOM   1747 C C   . ILE A 1 257 ? 182.36500 315.78600 -6.18200  1.000 85.91138  ? 292 ILE F C   1 
ATOM   1748 O O   . ILE A 1 257 ? 183.32100 316.06500 -6.92100  1.000 81.11523  ? 292 ILE F O   1 
ATOM   1749 C CB  . ILE A 1 257 ? 181.03000 317.84100 -6.75500  1.000 82.81293  ? 292 ILE F CB  1 
ATOM   1750 C CG1 . ILE A 1 257 ? 180.68900 319.22200 -6.20200  1.000 84.99218  ? 292 ILE F CG1 1 
ATOM   1751 C CG2 . ILE A 1 257 ? 179.78600 317.30200 -7.39800  1.000 77.18693  ? 292 ILE F CG2 1 
ATOM   1752 C CD1 . ILE A 1 257 ? 181.86300 320.20100 -6.27400  1.000 82.72400  ? 292 ILE F CD1 1 
ATOM   1753 N N   . LYS A 1 258 ? 182.02300 314.53100 -5.90700  1.000 77.52834  ? 293 LYS F N   1 
ATOM   1754 C CA  . LYS A 1 258 ? 182.90100 313.43300 -6.29500  1.000 79.87194  ? 293 LYS F CA  1 
ATOM   1755 C C   . LYS A 1 258 ? 182.07200 312.17000 -6.38100  1.000 86.98394  ? 293 LYS F C   1 
ATOM   1756 O O   . LYS A 1 258 ? 181.38200 311.82500 -5.41600  1.000 85.84866  ? 293 LYS F O   1 
ATOM   1757 C CB  . LYS A 1 258 ? 184.07200 313.25000 -5.31800  1.000 92.71792  ? 293 LYS F CB  1 
ATOM   1758 C CG  . LYS A 1 258 ? 185.43800 313.39000 -5.99500  1.000 91.92578  ? 293 LYS F CG  1 
ATOM   1759 C CD  . LYS A 1 258 ? 186.59700 313.24600 -5.01300  1.000 91.83072  ? 293 LYS F CD  1 
ATOM   1760 C CE  . LYS A 1 258 ? 187.55100 314.44200 -5.06800  1.000 91.49409  ? 293 LYS F CE  1 
ATOM   1761 N NZ  . LYS A 1 258 ? 188.72600 314.28200 -4.14700  1.000 87.51773  ? 293 LYS F NZ  1 
ATOM   1762 N N   . GLU A 1 259 ? 182.19000 311.45100 -7.48800  1.000 88.28818  ? 294 GLU F N   1 
ATOM   1763 C CA  . GLU A 1 259 ? 181.50700 310.17400 -7.64700  1.000 87.44050  ? 294 GLU F CA  1 
ATOM   1764 C C   . GLU A 1 259 ? 180.01100 310.36700 -7.43800  1.000 86.75706  ? 294 GLU F C   1 
ATOM   1765 O O   . GLU A 1 259 ? 179.37600 309.67000 -6.63200  1.000 82.33488  ? 294 GLU F O   1 
ATOM   1766 C CB  . GLU A 1 259 ? 182.02000 309.18600 -6.59400  1.000 92.04180  ? 294 GLU F CB  1 
ATOM   1767 C CG  . GLU A 1 259 ? 183.47800 308.78500 -6.59500  1.000 99.21156  ? 294 GLU F CG  1 
ATOM   1768 C CD  . GLU A 1 259 ? 183.74500 307.84900 -5.43300  1.000 101.15429 ? 294 GLU F CD  1 
ATOM   1769 O OE1 . GLU A 1 259 ? 182.77600 307.59500 -4.68100  1.000 98.33405  ? 294 GLU F OE1 1 
ATOM   1770 O OE2 . GLU A 1 259 ? 184.89900 307.40300 -5.24500  1.000 102.28928 ? 294 GLU F OE2 1 
ATOM   1771 N N   . GLU A 1 260 ? 179.44300 311.31700 -8.18300  1.000 84.04279  ? 295 GLU F N   1 
ATOM   1772 C CA  . GLU A 1 260 ? 177.99500 311.51600 -8.20900  1.000 84.80221  ? 295 GLU F CA  1 
ATOM   1773 C C   . GLU A 1 260 ? 177.41800 311.81500 -6.82100  1.000 76.96357  ? 295 GLU F C   1 
ATOM   1774 O O   . GLU A 1 260 ? 176.32800 311.33600 -6.47800  1.000 70.78568  ? 295 GLU F O   1 
ATOM   1775 C CB  . GLU A 1 260 ? 177.25800 310.36300 -8.89800  1.000 84.19389  ? 295 GLU F CB  1 
ATOM   1776 C CG  . GLU A 1 260 ? 177.94300 309.88900 -10.16900 1.000 86.76293  ? 295 GLU F CG  1 
ATOM   1777 C CD  . GLU A 1 260 ? 177.15900 308.79000 -10.85200 1.000 92.21511  ? 295 GLU F CD  1 
ATOM   1778 O OE1 . GLU A 1 260 ? 176.61500 307.91800 -10.12900 1.000 82.12210  ? 295 GLU F OE1 1 
ATOM   1779 O OE2 . GLU A 1 260 ? 177.07200 308.82200 -12.10900 1.000 97.68990  ? 295 GLU F OE2 1 
ATOM   1780 N N   . VAL A 1 261 ? 178.18000 312.52400 -5.98500  1.000 77.78868  ? 296 VAL F N   1 
ATOM   1781 C CA  . VAL A 1 261 ? 177.75400 312.88600 -4.63300  1.000 72.91451  ? 296 VAL F CA  1 
ATOM   1782 C C   . VAL A 1 261 ? 178.15300 314.33400 -4.38600  1.000 72.58002  ? 296 VAL F C   1 
ATOM   1783 O O   . VAL A 1 261 ? 179.29000 314.73300 -4.66000  1.000 76.07376  ? 296 VAL F O   1 
ATOM   1784 C CB  . VAL A 1 261 ? 178.33900 311.99400 -3.52700  1.000 67.38918  ? 296 VAL F CB  1 
ATOM   1785 C CG1 . VAL A 1 261 ? 178.02400 312.62100 -2.19000  1.000 67.04027  ? 296 VAL F CG1 1 
ATOM   1786 C CG2 . VAL A 1 261 ? 177.73700 310.60800 -3.58300  1.000 72.89457  ? 296 VAL F CG2 1 
ATOM   1787 N N   . LEU A 1 262 ? 177.18800 315.13500 -3.95700  1.000 71.48962  ? 297 LEU F N   1 
ATOM   1788 C CA  . LEU A 1 262 ? 177.40100 316.50400 -3.51000  1.000 65.92391  ? 297 LEU F CA  1 
ATOM   1789 C C   . LEU A 1 262 ? 177.22000 316.53600 -2.00300  1.000 65.53764  ? 297 LEU F C   1 
ATOM   1790 O O   . LEU A 1 262 ? 176.14000 316.20100 -1.50500  1.000 65.37014  ? 297 LEU F O   1 
ATOM   1791 C CB  . LEU A 1 262 ? 176.43700 317.47500 -4.18100  1.000 64.91817  ? 297 LEU F CB  1 
ATOM   1792 C CG  . LEU A 1 262 ? 176.32500 318.79900 -3.44200  1.000 62.04000  ? 297 LEU F CG  1 
ATOM   1793 C CD1 . LEU A 1 262 ? 177.67200 319.51100 -3.44500  1.000 65.33132  ? 297 LEU F CD1 1 
ATOM   1794 C CD2 . LEU A 1 262 ? 175.28800 319.64100 -4.12100  1.000 61.05115  ? 297 LEU F CD2 1 
ATOM   1795 N N   . ALA A 1 263 ? 178.27800 316.88200 -1.28000  1.000 67.80885  ? 298 ALA F N   1 
ATOM   1796 C CA  . ALA A 1 263 ? 178.26500 316.87200 0.17900   1.000 68.18947  ? 298 ALA F CA  1 
ATOM   1797 C C   . ALA A 1 263 ? 178.63100 318.26100 0.68800   1.000 63.50414  ? 298 ALA F C   1 
ATOM   1798 O O   . ALA A 1 263 ? 179.48800 318.94200 0.11100   1.000 61.00942  ? 298 ALA F O   1 
ATOM   1799 C CB  . ALA A 1 263 ? 179.22200 315.82000 0.75800   1.000 69.14215  ? 298 ALA F CB  1 
ATOM   1800 N N   . TYR A 1 264 ? 177.97600 318.67200 1.77500   1.000 58.14502  ? 299 TYR F N   1 
ATOM   1801 C CA  . TYR A 1 264 ? 178.29300 319.92800 2.44100   1.000 57.41286  ? 299 TYR F CA  1 
ATOM   1802 C C   . TYR A 1 264 ? 178.00800 319.78300 3.92300   1.000 59.24056  ? 299 TYR F C   1 
ATOM   1803 O O   . TYR A 1 264 ? 177.15000 318.99100 4.33400   1.000 59.55832  ? 299 TYR F O   1 
ATOM   1804 C CB  . TYR A 1 264 ? 177.50100 321.10900 1.83300   1.000 55.15929  ? 299 TYR F CB  1 
ATOM   1805 C CG  . TYR A 1 264 ? 175.96900 321.01700 1.87700   1.000 53.62389  ? 299 TYR F CG  1 
ATOM   1806 C CD1 . TYR A 1 264 ? 175.25900 320.98100 3.07900   1.000 55.07026  ? 299 TYR F CD1 1 
ATOM   1807 C CD2 . TYR A 1 264 ? 175.23700 320.98300 0.69500   1.000 53.79545  ? 299 TYR F CD2 1 
ATOM   1808 C CE1 . TYR A 1 264 ? 173.86700 320.90800 3.08900   1.000 53.03947  ? 299 TYR F CE1 1 
ATOM   1809 C CE2 . TYR A 1 264 ? 173.85500 320.90200 0.69300   1.000 48.04594  ? 299 TYR F CE2 1 
ATOM   1810 C CZ  . TYR A 1 264 ? 173.17500 320.86600 1.88200   1.000 53.69719  ? 299 TYR F CZ  1 
ATOM   1811 O OH  . TYR A 1 264 ? 171.79600 320.79400 1.84500   1.000 48.41387  ? 299 TYR F OH  1 
ATOM   1812 N N   . VAL A 1 265 ? 178.80200 320.49000 4.73300   1.000 59.93082  ? 300 VAL F N   1 
ATOM   1813 C CA  . VAL A 1 265 ? 178.73100 320.33800 6.18100   1.000 58.58930  ? 300 VAL F CA  1 
ATOM   1814 C C   . VAL A 1 265 ? 177.93200 321.47900 6.77900   1.000 53.11453  ? 300 VAL F C   1 
ATOM   1815 O O   . VAL A 1 265 ? 178.08700 322.65000 6.38700   1.000 47.49327  ? 300 VAL F O   1 
ATOM   1816 C CB  . VAL A 1 265 ? 180.11700 320.26000 6.83000   1.000 60.70297  ? 300 VAL F CB  1 
ATOM   1817 C CG1 . VAL A 1 265 ? 179.98900 319.57500 8.19200   1.000 58.00879  ? 300 VAL F CG1 1 
ATOM   1818 C CG2 . VAL A 1 265 ? 181.06000 319.51900 5.95300   1.000 67.14688  ? 300 VAL F CG2 1 
ATOM   1819 N N   . VAL A 1 266 ? 177.00800 321.11300 7.64700   1.000 44.80864  ? 301 VAL F N   1 
ATOM   1820 C CA  . VAL A 1 266 ? 176.27700 322.04300 8.47500   1.000 49.63007  ? 301 VAL F CA  1 
ATOM   1821 C C   . VAL A 1 266 ? 176.81500 321.97800 9.89500   1.000 56.02006  ? 301 VAL F C   1 
ATOM   1822 O O   . VAL A 1 266 ? 176.86600 320.89000 10.48800  1.000 54.84430  ? 301 VAL F O   1 
ATOM   1823 C CB  . VAL A 1 266 ? 174.77100 321.77200 8.40400   1.000 43.36646  ? 301 VAL F CB  1 
ATOM   1824 C CG1 . VAL A 1 266 ? 174.05200 322.63300 9.39300   1.000 49.22825  ? 301 VAL F CG1 1 
ATOM   1825 C CG2 . VAL A 1 266 ? 174.30400 322.18400 7.02700   1.000 40.62061  ? 301 VAL F CG2 1 
ATOM   1826 N N   . GLN A 1 267 ? 177.24300 323.14100 10.43000  1.000 54.08611  ? 302 GLN F N   1 
ATOM   1827 C CA  . GLN A 1 267 ? 177.85200 323.25600 11.76000  1.000 47.27262  ? 302 GLN F CA  1 
ATOM   1828 C C   . GLN A 1 267 ? 176.81800 323.83300 12.71600  1.000 42.32054  ? 302 GLN F C   1 
ATOM   1829 O O   . GLN A 1 267 ? 176.45600 325.00700 12.60200  1.000 43.36728  ? 302 GLN F O   1 
ATOM   1830 C CB  . GLN A 1 267 ? 179.08800 324.14700 11.82100  1.000 47.11524  ? 302 GLN F CB  1 
ATOM   1831 C CG  . GLN A 1 267 ? 180.39300 323.43900 11.92300  1.000 49.41462  ? 302 GLN F CG  1 
ATOM   1832 C CD  . GLN A 1 267 ? 181.53200 324.40500 11.84900  1.000 50.95485  ? 302 GLN F CD  1 
ATOM   1833 O OE1 . GLN A 1 267 ? 182.59900 324.11300 11.31000  1.000 57.37846  ? 302 GLN F OE1 1 
ATOM   1834 N NE2 . GLN A 1 267 ? 181.34200 325.55300 12.47800  1.000 53.87838  ? 302 GLN F NE2 1 
ATOM   1835 N N   . LEU A 1 268 ? 176.32900 323.04400 13.57100  1.000 46.00725  ? 303 LEU F N   1 
ATOM   1836 C CA  . LEU A 1 268 ? 175.26000 323.50600 14.43200  1.000 42.81910  ? 303 LEU F CA  1 
ATOM   1837 C C   . LEU A 1 268 ? 175.81600 323.84500 15.81400  1.000 48.83942  ? 303 LEU F C   1 
ATOM   1838 O O   . LEU A 1 268 ? 176.73200 323.16900 16.29600  1.000 47.71133  ? 303 LEU F O   1 
ATOM   1839 C CB  . LEU A 1 268 ? 174.19500 322.41300 14.57800  1.000 39.56477  ? 303 LEU F CB  1 
ATOM   1840 C CG  . LEU A 1 268 ? 172.95200 322.57900 13.71700  1.000 46.65068  ? 303 LEU F CG  1 
ATOM   1841 C CD1 . LEU A 1 268 ? 173.34500 322.95500 12.29700  1.000 43.94269  ? 303 LEU F CD1 1 
ATOM   1842 C CD2 . LEU A 1 268 ? 172.11400 321.33200 13.75300  1.000 47.96157  ? 303 LEU F CD2 1 
ATOM   1843 N N   . PRO A 1 269 ? 175.25400 324.83200 16.52000  1.000 47.37584  ? 304 PRO F N   1 
ATOM   1844 C CA  . PRO A 1 269 ? 175.84200 325.24800 17.79500  1.000 42.95053  ? 304 PRO F CA  1 
ATOM   1845 C C   . PRO A 1 269 ? 175.55100 324.28500 18.92500  1.000 41.06886  ? 304 PRO F C   1 
ATOM   1846 O O   . PRO A 1 269 ? 174.43700 323.78000 19.05100  1.000 45.74455  ? 304 PRO F O   1 
ATOM   1847 C CB  . PRO A 1 269 ? 175.16400 326.59300 18.07100  1.000 41.29140  ? 304 PRO F CB  1 
ATOM   1848 C CG  . PRO A 1 269 ? 173.86600 326.49400 17.40900  1.000 40.13457  ? 304 PRO F CG  1 
ATOM   1849 C CD  . PRO A 1 269 ? 174.10700 325.68400 16.15900  1.000 41.51145  ? 304 PRO F CD  1 
ATOM   1850 N N   . LEU A 1 270 ? 176.54700 324.12000 19.80200  1.000 42.67529  ? 305 LEU F N   1 
ATOM   1851 C CA  . LEU A 1 270 ? 176.41900 323.39200 21.06200  1.000 43.00096  ? 305 LEU F CA  1 
ATOM   1852 C C   . LEU A 1 270 ? 176.56700 324.41600 22.16200  1.000 40.44821  ? 305 LEU F C   1 
ATOM   1853 O O   . LEU A 1 270 ? 177.57900 325.11700 22.23600  1.000 43.39293  ? 305 LEU F O   1 
ATOM   1854 C CB  . LEU A 1 270 ? 177.45700 322.28100 21.25500  1.000 44.04444  ? 305 LEU F CB  1 
ATOM   1855 C CG  . LEU A 1 270 ? 177.31200 320.97300 20.49200  1.000 52.40834  ? 305 LEU F CG  1 
ATOM   1856 C CD1 . LEU A 1 270 ? 178.43300 320.02800 20.92000  1.000 51.87755  ? 305 LEU F CD1 1 
ATOM   1857 C CD2 . LEU A 1 270 ? 175.89900 320.34900 20.75000  1.000 40.40306  ? 305 LEU F CD2 1 
ATOM   1858 N N   . TYR A 1 271 ? 175.53900 324.52600 22.98100  1.000 37.14115  ? 306 TYR F N   1 
ATOM   1859 C CA  . TYR A 1 271 ? 175.49700 325.51300 24.03700  1.000 33.00426  ? 306 TYR F CA  1 
ATOM   1860 C C   . TYR A 1 271 ? 175.95500 324.81800 25.31200  1.000 36.87780  ? 306 TYR F C   1 
ATOM   1861 O O   . TYR A 1 271 ? 175.15300 324.23100 26.04900  1.000 39.47920  ? 306 TYR F O   1 
ATOM   1862 C CB  . TYR A 1 271 ? 174.09600 326.11000 24.15600  1.000 35.82426  ? 306 TYR F CB  1 
ATOM   1863 C CG  . TYR A 1 271 ? 173.62200 326.81800 22.87800  1.000 40.92870  ? 306 TYR F CG  1 
ATOM   1864 C CD1 . TYR A 1 271 ? 174.03200 328.12600 22.56600  1.000 43.72675  ? 306 TYR F CD1 1 
ATOM   1865 C CD2 . TYR A 1 271 ? 172.71000 326.20600 22.02600  1.000 37.51283  ? 306 TYR F CD2 1 
ATOM   1866 C CE1 . TYR A 1 271 ? 173.58900 328.77300 21.41100  1.000 37.67160  ? 306 TYR F CE1 1 
ATOM   1867 C CE2 . TYR A 1 271 ? 172.27300 326.83000 20.88400  1.000 37.92345  ? 306 TYR F CE2 1 
ATOM   1868 C CZ  . TYR A 1 271 ? 172.70000 328.11400 20.57800  1.000 40.85820  ? 306 TYR F CZ  1 
ATOM   1869 O OH  . TYR A 1 271 ? 172.23700 328.72100 19.42900  1.000 32.46172  ? 306 TYR F OH  1 
ATOM   1870 N N   . GLY A 1 272 ? 177.26600 324.89500 25.57400  1.000 37.70066  ? 307 GLY F N   1 
ATOM   1871 C CA  . GLY A 1 272 ? 177.83500 324.33800 26.79600  1.000 37.32914  ? 307 GLY F CA  1 
ATOM   1872 C C   . GLY A 1 272 ? 177.44500 325.10100 28.05200  1.000 41.03148  ? 307 GLY F C   1 
ATOM   1873 O O   . GLY A 1 272 ? 177.43700 324.52400 29.15700  1.000 38.99661  ? 307 GLY F O   1 
ATOM   1874 N N   . VAL A 1 273 ? 177.02200 326.35300 27.90000  1.000 37.28185  ? 308 VAL F N   1 
ATOM   1875 C CA  . VAL A 1 273 ? 176.58000 327.17300 29.02200  1.000 37.84001  ? 308 VAL F CA  1 
ATOM   1876 C C   . VAL A 1 273 ? 175.07200 327.35600 28.90600  1.000 33.90128  ? 308 VAL F C   1 
ATOM   1877 O O   . VAL A 1 273 ? 174.57500 327.81900 27.87400  1.000 39.96228  ? 308 VAL F O   1 
ATOM   1878 C CB  . VAL A 1 273 ? 177.31400 328.52200 29.04600  1.000 32.54876  ? 308 VAL F CB  1 
ATOM   1879 C CG1 . VAL A 1 273 ? 177.16500 329.16600 30.40900  1.000 29.22943  ? 308 VAL F CG1 1 
ATOM   1880 C CG2 . VAL A 1 273 ? 178.78300 328.33200 28.70800  1.000 30.33466  ? 308 VAL F CG2 1 
ATOM   1881 N N   . ILE A 1 274 ? 174.33400 326.88400 29.89300  1.000 29.05200  ? 309 ILE F N   1 
ATOM   1882 C CA  . ILE A 1 274 ? 172.87900 326.97200 29.86700  1.000 33.35709  ? 309 ILE F CA  1 
ATOM   1883 C C   . ILE A 1 274 ? 172.30100 327.55900 31.13600  1.000 37.76770  ? 309 ILE F C   1 
ATOM   1884 O O   . ILE A 1 274 ? 172.73600 327.24300 32.25000  1.000 41.10440  ? 309 ILE F O   1 
ATOM   1885 C CB  . ILE A 1 274 ? 172.21700 325.60400 29.59800  1.000 37.78387  ? 309 ILE F CB  1 
ATOM   1886 C CG1 . ILE A 1 274 ? 172.65000 325.08300 28.23200  1.000 41.99893  ? 309 ILE F CG1 1 
ATOM   1887 C CG2 . ILE A 1 274 ? 170.70700 325.63000 29.88700  1.000 45.88505  ? 309 ILE F CG2 1 
ATOM   1888 C CD1 . ILE A 1 274 ? 171.70600 325.61000 27.13200  1.000 43.22746  ? 309 ILE F CD1 1 
ATOM   1889 N N   . ASP A 1 275 ? 171.30400 328.41800 30.95000  1.000 33.54399  ? 310 ASP F N   1 
ATOM   1890 C CA  . ASP A 1 275 ? 170.60100 329.02100 32.05700  1.000 37.65658  ? 310 ASP F CA  1 
ATOM   1891 C C   . ASP A 1 275 ? 171.56500 329.78800 32.93800  1.000 31.00326  ? 310 ASP F C   1 
ATOM   1892 O O   . ASP A 1 275 ? 171.39600 329.84300 34.15400  1.000 37.34352  ? 310 ASP F O   1 
ATOM   1893 C CB  . ASP A 1 275 ? 169.83700 327.95100 32.83500  1.000 44.57327  ? 310 ASP F CB  1 
ATOM   1894 C CG  . ASP A 1 275 ? 168.55300 327.53400 32.11000  1.000 53.19009  ? 310 ASP F CG  1 
ATOM   1895 O OD1 . ASP A 1 275 ? 168.59000 327.49500 30.85400  1.000 55.54144  ? 310 ASP F OD1 1 
ATOM   1896 O OD2 . ASP A 1 275 ? 167.52400 327.24600 32.77200  1.000 58.80731  ? 310 ASP F OD2 1 
ATOM   1897 N N   . THR A 1 276 ? 172.52600 330.45400 32.31000  1.000 25.81727  ? 311 THR F N   1 
ATOM   1898 C CA  . THR A 1 276 ? 173.44300 331.24700 33.11700  1.000 27.15813  ? 311 THR F CA  1 
ATOM   1899 C C   . THR A 1 276 ? 172.89600 332.66700 33.27600  1.000 30.75133  ? 311 THR F C   1 
ATOM   1900 O O   . THR A 1 276 ? 172.31000 333.22800 32.34400  1.000 28.91814  ? 311 THR F O   1 
ATOM   1901 C CB  . THR A 1 276 ? 174.81400 331.29500 32.44200  1.000 29.72083  ? 311 THR F CB  1 
ATOM   1902 O OG1 . THR A 1 276 ? 175.72400 332.10400 33.18500  1.000 28.67199  ? 311 THR F OG1 1 
ATOM   1903 C CG2 . THR A 1 276 ? 174.66600 331.93600 31.09000  1.000 26.48322  ? 311 THR F CG2 1 
ATOM   1904 N N   . PRO A 1 277 ? 173.09100 333.29700 34.42200  1.000 31.65933  ? 312 PRO F N   1 
ATOM   1905 C CA  . PRO A 1 277 ? 172.59500 334.66800 34.59800  1.000 29.28898  ? 312 PRO F CA  1 
ATOM   1906 C C   . PRO A 1 277 ? 173.22400 335.63800 33.60300  1.000 28.72683  ? 312 PRO F C   1 
ATOM   1907 O O   . PRO A 1 277 ? 174.44400 335.65200 33.39700  1.000 29.13553  ? 312 PRO F O   1 
ATOM   1908 C CB  . PRO A 1 277 ? 173.02300 334.99600 36.03300  1.000 28.15358  ? 312 PRO F CB  1 
ATOM   1909 C CG  . PRO A 1 277 ? 173.16300 333.71000 36.67800  1.000 22.38637  ? 312 PRO F CG  1 
ATOM   1910 C CD  . PRO A 1 277 ? 173.67000 332.75800 35.65100  1.000 22.63625  ? 312 PRO F CD  1 
ATOM   1911 N N   . CYS A 1 278 ? 172.39100 336.49100 33.01200  1.000 27.73403  ? 313 CYS F N   1 
ATOM   1912 C CA  . CYS A 1 278 ? 172.89500 337.46300 32.05000  1.000 27.16690  ? 313 CYS F CA  1 
ATOM   1913 C C   . CYS A 1 278 ? 172.22300 338.79800 32.33600  1.000 27.90172  ? 313 CYS F C   1 
ATOM   1914 O O   . CYS A 1 278 ? 171.12100 338.84400 32.89500  1.000 27.90706  ? 313 CYS F O   1 
ATOM   1915 C CB  . CYS A 1 278 ? 172.62000 337.03800 30.59600  1.000 23.81177  ? 313 CYS F CB  1 
ATOM   1916 S SG  . CYS A 1 278 ? 173.62700 335.61400 30.03800  1.000 28.91865  ? 313 CYS F SG  1 
ATOM   1917 N N   . TRP A 1 279 ? 172.89700 339.88100 31.94600  1.000 28.37554  ? 314 TRP F N   1 
ATOM   1918 C CA  . TRP A 1 279 ? 172.37000 341.22900 32.09600  1.000 25.35588  ? 314 TRP F CA  1 
ATOM   1919 C C   . TRP A 1 279 ? 172.90500 342.11000 30.96600  1.000 26.75740  ? 314 TRP F C   1 
ATOM   1920 O O   . TRP A 1 279 ? 173.91300 341.78900 30.32200  1.000 24.38716  ? 314 TRP F O   1 
ATOM   1921 C CB  . TRP A 1 279 ? 172.71300 341.80000 33.47700  1.000 25.75351  ? 314 TRP F CB  1 
ATOM   1922 C CG  . TRP A 1 279 ? 174.19300 341.89700 33.80800  1.000 28.88736  ? 314 TRP F CG  1 
ATOM   1923 C CD1 . TRP A 1 279 ? 174.97300 343.01800 33.72100  1.000 28.57946  ? 314 TRP F CD1 1 
ATOM   1924 C CD2 . TRP A 1 279 ? 175.04600 340.85600 34.31200  1.000 26.61156  ? 314 TRP F CD2 1 
ATOM   1925 N NE1 . TRP A 1 279 ? 176.26800 342.74100 34.12300  1.000 30.39852  ? 314 TRP F NE1 1 
ATOM   1926 C CE2 . TRP A 1 279 ? 176.34200 341.42100 34.48400  1.000 31.49507  ? 314 TRP F CE2 1 
ATOM   1927 C CE3 . TRP A 1 279 ? 174.85000 339.50600 34.62100  1.000 23.13736  ? 314 TRP F CE3 1 
ATOM   1928 C CZ2 . TRP A 1 279 ? 177.43600 340.67400 34.94600  1.000 27.27593  ? 314 TRP F CZ2 1 
ATOM   1929 C CZ3 . TRP A 1 279 ? 175.92900 338.76500 35.08500  1.000 22.29713  ? 314 TRP F CZ3 1 
ATOM   1930 C CH2 . TRP A 1 279 ? 177.20600 339.35200 35.24500  1.000 28.96454  ? 314 TRP F CH2 1 
ATOM   1931 N N   . LYS A 1 280 ? 172.19600 343.21500 30.71700  1.000 22.56864  ? 315 LYS F N   1 
ATOM   1932 C CA  . LYS A 1 280 ? 172.52600 344.19200 29.68000  1.000 19.14935  ? 315 LYS F CA  1 
ATOM   1933 C C   . LYS A 1 280 ? 172.74200 345.57500 30.29500  1.000 18.70244  ? 315 LYS F C   1 
ATOM   1934 O O   . LYS A 1 280 ? 171.90900 346.03600 31.08300  1.000 23.73761  ? 315 LYS F O   1 
ATOM   1935 C CB  . LYS A 1 280 ? 171.42300 344.26600 28.63700  1.000 22.90294  ? 315 LYS F CB  1 
ATOM   1936 C CG  . LYS A 1 280 ? 171.82900 345.13700 27.47200  1.000 24.88259  ? 315 LYS F CG  1 
ATOM   1937 C CD  . LYS A 1 280 ? 170.89400 345.05900 26.34100  1.000 19.33276  ? 315 LYS F CD  1 
ATOM   1938 C CE  . LYS A 1 280 ? 171.44800 345.80500 25.16700  1.000 21.22210  ? 315 LYS F CE  1 
ATOM   1939 N NZ  . LYS A 1 280 ? 170.53100 345.67000 23.99200  1.000 30.10621  ? 315 LYS F NZ  1 
ATOM   1940 N N   . LEU A 1 281 ? 173.91600 346.16000 30.07100  1.000 18.72394  ? 316 LEU F N   1 
ATOM   1941 C CA  . LEU A 1 281 ? 174.26100 347.48000 30.59500  1.000 19.63856  ? 316 LEU F CA  1 
ATOM   1942 C C   . LEU A 1 281 ? 173.91900 348.55700 29.55400  1.000 22.74803  ? 316 LEU F C   1 
ATOM   1943 O O   . LEU A 1 281 ? 174.31400 348.43800 28.38200  1.000 20.36162  ? 316 LEU F O   1 
ATOM   1944 C CB  . LEU A 1 281 ? 175.73500 347.52000 30.96700  1.000 19.31926  ? 316 LEU F CB  1 
ATOM   1945 C CG  . LEU A 1 281 ? 176.44900 348.80800 31.39200  1.000 22.46856  ? 316 LEU F CG  1 
ATOM   1946 C CD1 . LEU A 1 281 ? 175.90600 349.40900 32.67400  1.000 20.60872  ? 316 LEU F CD1 1 
ATOM   1947 C CD2 . LEU A 1 281 ? 177.96200 348.57200 31.48900  1.000 19.59936  ? 316 LEU F CD2 1 
ATOM   1948 N N   . HIS A 1 282 ? 173.20500 349.61100 29.97900  1.000 18.44077  ? 317 HIS F N   1 
ATOM   1949 C CA  . HIS A 1 282 ? 172.87000 350.74000 29.12200  1.000 14.95270  ? 317 HIS F CA  1 
ATOM   1950 C C   . HIS A 1 282 ? 173.52300 352.00200 29.67400  1.000 19.46223  ? 317 HIS F C   1 
ATOM   1951 O O   . HIS A 1 282 ? 173.40900 352.29700 30.86800  1.000 20.51832  ? 317 HIS F O   1 
ATOM   1952 C CB  . HIS A 1 282 ? 171.37000 350.94200 29.13000  1.000 15.53451  ? 317 HIS F CB  1 
ATOM   1953 C CG  . HIS A 1 282 ? 170.59200 349.71300 28.78600  1.000 20.22055  ? 317 HIS F CG  1 
ATOM   1954 N ND1 . HIS A 1 282 ? 170.20300 349.39100 27.50100  1.000 20.06699  ? 317 HIS F ND1 1 
ATOM   1955 C CD2 . HIS A 1 282 ? 170.09200 348.73400 29.59400  1.000 20.94124  ? 317 HIS F CD2 1 
ATOM   1956 C CE1 . HIS A 1 282 ? 169.51000 348.25700 27.53300  1.000 24.43863  ? 317 HIS F CE1 1 
ATOM   1957 N NE2 . HIS A 1 282 ? 169.42200 347.84200 28.78900  1.000 17.80619  ? 317 HIS F NE2 1 
ATOM   1958 N N   . THR A 1 283 ? 174.17600 352.77000 28.82500  1.000 22.31505  ? 318 THR F N   1 
ATOM   1959 C CA  . THR A 1 283 ? 174.86400 353.95100 29.32000  1.000 21.99951  ? 318 THR F CA  1 
ATOM   1960 C C   . THR A 1 283 ? 174.43400 355.16800 28.51400  1.000 20.63198  ? 318 THR F C   1 
ATOM   1961 O O   . THR A 1 283 ? 174.11400 355.05700 27.33500  1.000 24.46671  ? 318 THR F O   1 
ATOM   1962 C CB  . THR A 1 283 ? 176.38400 353.75400 29.25200  1.000 22.51144  ? 318 THR F CB  1 
ATOM   1963 O OG1 . THR A 1 283 ? 176.75900 353.64300 27.87600  1.000 31.02966  ? 318 THR F OG1 1 
ATOM   1964 C CG2 . THR A 1 283 ? 176.76400 352.46100 29.95400  1.000 15.73162  ? 318 THR F CG2 1 
ATOM   1965 N N   . SER A 1 284 ? 174.50600 356.34600 29.12000  1.000 22.12461  ? 319 SER F N   1 
ATOM   1966 C CA  . SER A 1 284 ? 174.10200 357.55700 28.42700  1.000 19.95208  ? 319 SER F CA  1 
ATOM   1967 C C   . SER A 1 284 ? 174.97700 358.66500 28.98000  1.000 22.74495  ? 319 SER F C   1 
ATOM   1968 O O   . SER A 1 284 ? 175.50200 358.51600 30.09500  1.000 22.84138  ? 319 SER F O   1 
ATOM   1969 C CB  . SER A 1 284 ? 172.61600 357.84900 28.62800  1.000 21.28094  ? 319 SER F CB  1 
ATOM   1970 O OG  . SER A 1 284 ? 172.20100 358.84900 27.71400  1.000 29.64601  ? 319 SER F OG  1 
ATOM   1971 N N   . PRO A 1 285 ? 175.27400 359.70800 28.18600  1.000 22.88231  ? 320 PRO F N   1 
ATOM   1972 C CA  . PRO A 1 285 ? 176.19200 360.77100 28.65500  1.000 21.37358  ? 320 PRO F CA  1 
ATOM   1973 C C   . PRO A 1 285 ? 175.62800 361.47500 29.87300  1.000 23.90029  ? 320 PRO F C   1 
ATOM   1974 O O   . PRO A 1 285 ? 174.44900 361.85200 29.89400  1.000 25.12569  ? 320 PRO F O   1 
ATOM   1975 C CB  . PRO A 1 285 ? 176.28000 361.72300 27.46900  1.000 23.00023  ? 320 PRO F CB  1 
ATOM   1976 C CG  . PRO A 1 285 ? 175.94400 360.91300 26.29300  1.000 25.33013  ? 320 PRO F CG  1 
ATOM   1977 C CD  . PRO A 1 285 ? 174.88000 359.90400 26.79200  1.000 18.05372  ? 320 PRO F CD  1 
ATOM   1978 N N   . LEU A 1 286 ? 176.52100 361.74600 30.83600  1.000 26.17429  ? 321 LEU F N   1 
ATOM   1979 C CA  . LEU A 1 286 ? 176.25800 362.41200 32.12100  1.000 25.44605  ? 321 LEU F CA  1 
ATOM   1980 C C   . LEU A 1 286 ? 177.03700 363.72400 32.18600  1.000 29.35737  ? 321 LEU F C   1 
ATOM   1981 O O   . LEU A 1 286 ? 178.26100 363.70600 32.37000  1.000 30.49171  ? 321 LEU F O   1 
ATOM   1982 C CB  . LEU A 1 286 ? 176.71700 361.54100 33.28500  1.000 27.93031  ? 321 LEU F CB  1 
ATOM   1983 C CG  . LEU A 1 286 ? 176.44900 362.13900 34.67700  1.000 27.51697  ? 321 LEU F CG  1 
ATOM   1984 C CD1 . LEU A 1 286 ? 174.98300 362.15400 34.95200  1.000 25.49403  ? 321 LEU F CD1 1 
ATOM   1985 C CD2 . LEU A 1 286 ? 177.20100 361.44300 35.79100  1.000 29.38462  ? 321 LEU F CD2 1 
ATOM   1986 N N   . CYS A 1 287 ? 176.36500 364.84900 31.94800  1.000 28.18617  ? 322 CYS F N   1 
ATOM   1987 C CA  . CYS A 1 287 ? 177.00400 366.15900 31.93000  1.000 27.46264  ? 322 CYS F CA  1 
ATOM   1988 C C   . CYS A 1 287 ? 176.54600 367.03900 33.08000  1.000 32.04268  ? 322 CYS F C   1 
ATOM   1989 O O   . CYS A 1 287 ? 175.49100 366.82500 33.68900  1.000 37.90968  ? 322 CYS F O   1 
ATOM   1990 C CB  . CYS A 1 287 ? 176.70400 366.87400 30.62100  1.000 26.65705  ? 322 CYS F CB  1 
ATOM   1991 S SG  . CYS A 1 287 ? 177.12300 365.89400 29.21100  1.000 39.06875  ? 322 CYS F SG  1 
ATOM   1992 N N   . THR A 1 288 ? 177.28300 368.12400 33.28200  1.000 32.93405  ? 323 THR F N   1 
ATOM   1993 C CA  . THR A 1 288 ? 176.79200 369.07800 34.25000  1.000 34.30814  ? 323 THR F CA  1 
ATOM   1994 C C   . THR A 1 288 ? 175.80600 369.99800 33.55100  1.000 36.40748  ? 323 THR F C   1 
ATOM   1995 O O   . THR A 1 288 ? 175.80500 370.14000 32.33000  1.000 37.76174  ? 323 THR F O   1 
ATOM   1996 C CB  . THR A 1 288 ? 177.94300 369.89200 34.87600  1.000 34.13118  ? 323 THR F CB  1 
ATOM   1997 O OG1 . THR A 1 288 ? 178.75400 370.50600 33.85800  1.000 31.58245  ? 323 THR F OG1 1 
ATOM   1998 C CG2 . THR A 1 288 ? 178.79300 369.04100 35.78600  1.000 30.13380  ? 323 THR F CG2 1 
ATOM   1999 N N   . THR A 1 289 ? 174.96800 370.64300 34.34900  1.000 42.00274  ? 324 THR F N   1 
ATOM   2000 C CA  . THR A 1 289 ? 173.87800 371.40900 33.76700  1.000 46.49589  ? 324 THR F CA  1 
ATOM   2001 C C   . THR A 1 289 ? 174.01600 372.89200 34.05900  1.000 51.13010  ? 324 THR F C   1 
ATOM   2002 O O   . THR A 1 289 ? 173.04500 373.56400 34.41300  1.000 53.25811  ? 324 THR F O   1 
ATOM   2003 C CB  . THR A 1 289 ? 172.55400 370.85500 34.27500  1.000 43.19456  ? 324 THR F CB  1 
ATOM   2004 O OG1 . THR A 1 289 ? 172.54200 370.90100 35.71200  1.000 53.40549  ? 324 THR F OG1 1 
ATOM   2005 C CG2 . THR A 1 289 ? 172.33100 369.43800 33.77200  1.000 39.46776  ? 324 THR F CG2 1 
ATOM   2006 N N   . ASN A 1 290 ? 175.21200 373.41600 33.85900  1.000 52.63291  ? 325 ASN F N   1 
ATOM   2007 C CA  . ASN A 1 290 ? 175.40700 374.84500 33.95600  1.000 57.96234  ? 325 ASN F CA  1 
ATOM   2008 C C   . ASN A 1 290 ? 174.83700 375.53400 32.71900  1.000 61.53397  ? 325 ASN F C   1 
ATOM   2009 O O   . ASN A 1 290 ? 174.68800 374.92500 31.65600  1.000 56.93934  ? 325 ASN F O   1 
ATOM   2010 C CB  . ASN A 1 290 ? 176.90300 375.12900 34.08100  1.000 60.47858  ? 325 ASN F CB  1 
ATOM   2011 C CG  . ASN A 1 290 ? 177.37300 375.09900 35.51400  1.000 64.27022  ? 325 ASN F CG  1 
ATOM   2012 O OD1 . ASN A 1 290 ? 176.58700 374.85100 36.43800  1.000 66.22416  ? 325 ASN F OD1 1 
ATOM   2013 N ND2 . ASN A 1 290 ? 178.66900 375.28300 35.70600  1.000 68.22327  ? 325 ASN F ND2 1 
ATOM   2014 N N   . THR A 1 291 ? 174.51300 376.82300 32.86900  1.000 77.80409  ? 326 THR F N   1 
ATOM   2015 C CA  . THR A 1 291 ? 173.83000 377.61300 31.84000  1.000 75.99220  ? 326 THR F CA  1 
ATOM   2016 C C   . THR A 1 291 ? 174.78200 378.33300 30.89800  1.000 79.96834  ? 326 THR F C   1 
ATOM   2017 O O   . THR A 1 291 ? 174.33100 378.82600 29.85300  1.000 82.30732  ? 326 THR F O   1 
ATOM   2018 C CB  . THR A 1 291 ? 172.87600 378.63600 32.46800  1.000 73.14250  ? 326 THR F CB  1 
ATOM   2019 O OG1 . THR A 1 291 ? 173.45200 379.18900 33.67200  1.000 84.54135  ? 326 THR F OG1 1 
ATOM   2020 C CG2 . THR A 1 291 ? 171.52800 377.96800 32.79600  1.000 71.01624  ? 326 THR F CG2 1 
ATOM   2021 N N   . LYS A 1 292 ? 176.09200 378.27100 31.15700  1.000 77.98042  ? 327 LYS F N   1 
ATOM   2022 C CA  . LYS A 1 292 ? 177.08000 378.98800 30.36000  1.000 77.93659  ? 327 LYS F CA  1 
ATOM   2023 C C   . LYS A 1 292 ? 177.90200 377.95700 29.58400  1.000 83.37222  ? 327 LYS F C   1 
ATOM   2024 O O   . LYS A 1 292 ? 178.63500 377.14700 30.17000  1.000 72.56085  ? 327 LYS F O   1 
ATOM   2025 C CB  . LYS A 1 292 ? 178.01200 379.81100 31.25900  1.000 75.14558  ? 327 LYS F CB  1 
ATOM   2026 C CG  . LYS A 1 292 ? 178.14500 379.33100 32.70800  1.000 76.75697  ? 327 LYS F CG  1 
ATOM   2027 C CD  . LYS A 1 292 ? 178.59000 380.39100 33.66000  1.000 78.87190  ? 327 LYS F CD  1 
ATOM   2028 C CE  . LYS A 1 292 ? 179.78300 379.90100 34.50100  1.000 76.69732  ? 327 LYS F CE  1 
ATOM   2029 N NZ  . LYS A 1 292 ? 179.62000 378.61500 35.29000  1.000 71.16497  ? 327 LYS F NZ  1 
ATOM   2030 N N   . GLU A 1 293 ? 177.80000 378.01500 28.25300  1.000 84.13186  ? 328 GLU F N   1 
ATOM   2031 C CA  . GLU A 1 293 ? 178.51200 377.07200 27.40200  1.000 85.24837  ? 328 GLU F CA  1 
ATOM   2032 C C   . GLU A 1 293 ? 180.02100 377.28200 27.47100  1.000 84.84494  ? 328 GLU F C   1 
ATOM   2033 O O   . GLU A 1 293 ? 180.50900 378.41400 27.59100  1.000 81.49252  ? 328 GLU F O   1 
ATOM   2034 C CB  . GLU A 1 293 ? 178.00100 377.19600 25.95300  1.000 82.85598  ? 328 GLU F CB  1 
ATOM   2035 C CG  . GLU A 1 293 ? 178.36300 378.49900 25.19300  1.000 83.66248  ? 328 GLU F CG  1 
ATOM   2036 C CD  . GLU A 1 293 ? 178.35500 378.33500 23.64100  1.000 85.53982  ? 328 GLU F CD  1 
ATOM   2037 O OE1 . GLU A 1 293 ? 177.63400 377.43100 23.13800  1.000 75.49560  ? 328 GLU F OE1 1 
ATOM   2038 O OE2 . GLU A 1 293 ? 179.07900 379.08800 22.92200  1.000 71.26365  ? 328 GLU F OE2 1 
ATOM   2039 N N   . GLY A 1 294 ? 180.75300 376.15700 27.49900  1.000 77.80414  ? 329 GLY F N   1 
ATOM   2040 C CA  . GLY A 1 294 ? 182.16600 376.15900 27.79300  1.000 74.52490  ? 329 GLY F CA  1 
ATOM   2041 C C   . GLY A 1 294 ? 182.52900 375.85700 29.22900  1.000 77.52872  ? 329 GLY F C   1 
ATOM   2042 O O   . GLY A 1 294 ? 183.72400 375.68900 29.52400  1.000 81.32841  ? 329 GLY F O   1 
ATOM   2043 N N   . SER A 1 295 ? 181.54300 375.74900 30.12200  1.000 71.44654  ? 330 SER F N   1 
ATOM   2044 C CA  . SER A 1 295 ? 181.78100 375.42700 31.52300  1.000 64.85362  ? 330 SER F CA  1 
ATOM   2045 C C   . SER A 1 295 ? 181.19700 374.08800 31.91200  1.000 59.59656  ? 330 SER F C   1 
ATOM   2046 O O   . SER A 1 295 ? 181.15500 373.76400 33.10500  1.000 53.99587  ? 330 SER F O   1 
ATOM   2047 C CB  . SER A 1 295 ? 181.19000 376.51400 32.42200  1.000 67.95978  ? 330 SER F CB  1 
ATOM   2048 O OG  . SER A 1 295 ? 179.77400 376.56900 32.28100  1.000 65.44520  ? 330 SER F OG  1 
ATOM   2049 N N   . ASN A 1 296 ? 180.86900 373.24800 30.93900  1.000 57.51467  ? 331 ASN F N   1 
ATOM   2050 C CA  . ASN A 1 296 ? 180.23600 371.99300 31.27100  1.000 50.73697  ? 331 ASN F CA  1 
ATOM   2051 C C   . ASN A 1 296 ? 181.17200 370.85700 30.90300  1.000 46.82638  ? 331 ASN F C   1 
ATOM   2052 O O   . ASN A 1 296 ? 181.90500 370.93200 29.91300  1.000 46.50438  ? 331 ASN F O   1 
ATOM   2053 C CB  . ASN A 1 296 ? 178.93200 371.85200 30.48700  1.000 45.89566  ? 331 ASN F CB  1 
ATOM   2054 C CG  . ASN A 1 296 ? 177.78900 372.57800 31.14000  1.000 48.85423  ? 331 ASN F CG  1 
ATOM   2055 O OD1 . ASN A 1 296 ? 177.60000 372.48300 32.35000  1.000 48.88369  ? 331 ASN F OD1 1 
ATOM   2056 N ND2 . ASN A 1 296 ? 177.00000 373.29400 30.34200  1.000 47.31625  ? 331 ASN F ND2 1 
ATOM   2057 N N   . ILE A 1 297 ? 181.14400 369.81100 31.72300  1.000 40.04428  ? 332 ILE F N   1 
ATOM   2058 C CA  . ILE A 1 297 ? 181.95500 368.62300 31.51100  1.000 38.65152  ? 332 ILE F CA  1 
ATOM   2059 C C   . ILE A 1 297 ? 181.05800 367.40100 31.45000  1.000 32.39668  ? 332 ILE F C   1 
ATOM   2060 O O   . ILE A 1 297 ? 179.98200 367.37800 32.05200  1.000 33.35020  ? 332 ILE F O   1 
ATOM   2061 C CB  . ILE A 1 297 ? 183.02000 368.47100 32.61000  1.000 38.56512  ? 332 ILE F CB  1 
ATOM   2062 C CG1 . ILE A 1 297 ? 182.33800 368.45500 33.98500  1.000 31.62937  ? 332 ILE F CG1 1 
ATOM   2063 C CG2 . ILE A 1 297 ? 184.10400 369.54300 32.42400  1.000 31.02454  ? 332 ILE F CG2 1 
ATOM   2064 C CD1 . ILE A 1 297 ? 183.28700 368.30800 35.14800  1.000 32.76571  ? 332 ILE F CD1 1 
ATOM   2065 N N   . CYS A 1 298 ? 181.49000 366.39500 30.71600  1.000 35.81737  ? 333 CYS F N   1 
ATOM   2066 C CA  . CYS A 1 298 ? 180.69000 365.20600 30.55400  1.000 31.84340  ? 333 CYS F CA  1 
ATOM   2067 C C   . CYS A 1 298 ? 181.43200 363.89800 30.78700  1.000 30.22910  ? 333 CYS F C   1 
ATOM   2068 O O   . CYS A 1 298 ? 182.63300 363.83300 30.65100  1.000 23.76966  ? 333 CYS F O   1 
ATOM   2069 C CB  . CYS A 1 298 ? 180.05100 365.21700 29.16200  1.000 29.64643  ? 333 CYS F CB  1 
ATOM   2070 S SG  . CYS A 1 298 ? 178.97200 366.59300 28.77000  1.000 45.06393  ? 333 CYS F SG  1 
ATOM   2071 N N   . LEU A 1 299 ? 180.70100 362.86000 31.16100  1.000 35.42225  ? 334 LEU F N   1 
ATOM   2072 C CA  . LEU A 1 299 ? 181.25900 361.54000 31.41300  1.000 26.88087  ? 334 LEU F CA  1 
ATOM   2073 C C   . LEU A 1 299 ? 180.27500 360.52300 30.91600  1.000 25.60887  ? 334 LEU F C   1 
ATOM   2074 O O   . LEU A 1 299 ? 179.09200 360.72200 31.02200  1.000 25.85868  ? 334 LEU F O   1 
ATOM   2075 C CB  . LEU A 1 299 ? 181.46100 361.36300 32.90700  1.000 25.35089  ? 334 LEU F CB  1 
ATOM   2076 C CG  . LEU A 1 299 ? 181.58000 360.05000 33.65900  1.000 35.67384  ? 334 LEU F CG  1 
ATOM   2077 C CD1 . LEU A 1 299 ? 182.25600 360.39100 34.97100  1.000 37.74853  ? 334 LEU F CD1 1 
ATOM   2078 C CD2 . LEU A 1 299 ? 180.22400 359.41600 33.92200  1.000 24.09118  ? 334 LEU F CD2 1 
ATOM   2079 N N   . THR A 1 300 ? 180.75100 359.43500 30.35400  1.000 27.68201  ? 335 THR F N   1 
ATOM   2080 C CA  . THR A 1 300 ? 179.87300 358.36300 29.93900  1.000 26.19219  ? 335 THR F CA  1 
ATOM   2081 C C   . THR A 1 300 ? 180.50800 357.02700 30.24000  1.000 26.78832  ? 335 THR F C   1 
ATOM   2082 O O   . THR A 1 300 ? 181.64000 356.80900 29.87000  1.000 28.00940  ? 335 THR F O   1 
ATOM   2083 C CB  . THR A 1 300 ? 179.53000 358.44000 28.44200  1.000 24.45089  ? 335 THR F CB  1 
ATOM   2084 O OG1 . THR A 1 300 ? 179.26500 359.79500 28.07900  1.000 36.73031  ? 335 THR F OG1 1 
ATOM   2085 C CG2 . THR A 1 300 ? 178.31600 357.59600 28.13800  1.000 21.62451  ? 335 THR F CG2 1 
ATOM   2086 N N   . ARG A 1 301 ? 179.79700 356.13800 30.92700  1.000 23.71860  ? 336 ARG F N   1 
ATOM   2087 C CA  . ARG A 1 301 ? 180.30700 354.79400 31.13900  1.000 25.71320  ? 336 ARG F CA  1 
ATOM   2088 C C   . ARG A 1 301 ? 180.45400 354.07400 29.80800  1.000 22.65338  ? 336 ARG F C   1 
ATOM   2089 O O   . ARG A 1 301 ? 179.64100 354.24600 28.89800  1.000 21.36929  ? 336 ARG F O   1 
ATOM   2090 C CB  . ARG A 1 301 ? 179.39100 353.99200 32.06200  1.000 24.70778  ? 336 ARG F CB  1 
ATOM   2091 C CG  . ARG A 1 301 ? 179.40900 354.42600 33.52200  1.000 21.69117  ? 336 ARG F CG  1 
ATOM   2092 C CD  . ARG A 1 301 ? 178.52600 353.47500 34.27900  1.000 24.39793  ? 336 ARG F CD  1 
ATOM   2093 N NE  . ARG A 1 301 ? 178.99800 352.10500 34.14900  1.000 23.47628  ? 336 ARG F NE  1 
ATOM   2094 C CZ  . ARG A 1 301 ? 178.39000 351.05000 34.67200  1.000 27.00465  ? 336 ARG F CZ  1 
ATOM   2095 N NH1 . ARG A 1 301 ? 177.26800 351.17500 35.35500  1.000 28.66990  ? 336 ARG F NH1 1 
ATOM   2096 N NH2 . ARG A 1 301 ? 178.97200 349.85100 34.58700  1.000 28.14545  ? 336 ARG F NH2 1 
ATOM   2097 N N   . THR A 1 302 ? 181.49600 353.27000 29.69500  1.000 23.59704  ? 337 THR F N   1 
ATOM   2098 C CA  . THR A 1 302 ? 181.75300 352.51800 28.47800  1.000 27.89789  ? 337 THR F CA  1 
ATOM   2099 C C   . THR A 1 302 ? 181.45400 351.04400 28.70100  1.000 28.56735  ? 337 THR F C   1 
ATOM   2100 O O   . THR A 1 302 ? 181.10500 350.57200 29.80000  1.000 29.03008  ? 337 THR F O   1 
ATOM   2101 C CB  . THR A 1 302 ? 183.16500 352.70900 27.95900  1.000 23.74090  ? 337 THR F CB  1 
ATOM   2102 O OG1 . THR A 1 302 ? 184.09500 352.37600 28.98300  1.000 34.23130  ? 337 THR F OG1 1 
ATOM   2103 C CG2 . THR A 1 302 ? 183.34900 354.13700 27.56900  1.000 27.76246  ? 337 THR F CG2 1 
ATOM   2104 N N   . ASP A 1 303 ? 181.67100 350.28900 27.64600  1.000 27.55142  ? 338 ASP F N   1 
ATOM   2105 C CA  . ASP A 1 303 ? 181.40800 348.85300 27.68800  1.000 35.08756  ? 338 ASP F CA  1 
ATOM   2106 C C   . ASP A 1 303 ? 179.93200 348.55900 27.97500  1.000 25.04729  ? 338 ASP F C   1 
ATOM   2107 O O   . ASP A 1 303 ? 179.55300 347.81400 28.87500  1.000 26.64637  ? 338 ASP F O   1 
ATOM   2108 C CB  . ASP A 1 303 ? 182.36500 348.16300 28.68100  1.000 29.70486  ? 338 ASP F CB  1 
ATOM   2109 C CG  . ASP A 1 303 ? 183.83500 348.28600 28.23700  1.000 35.80357  ? 338 ASP F CG  1 
ATOM   2110 O OD1 . ASP A 1 303 ? 184.04700 348.33800 26.99300  1.000 32.47954  ? 338 ASP F OD1 1 
ATOM   2111 O OD2 . ASP A 1 303 ? 184.75100 348.33700 29.09600  1.000 45.57735  ? 338 ASP F OD2 1 
ATOM   2112 N N   . ARG A 1 304 ? 179.10700 349.10300 27.10600  1.000 19.36116  ? 339 ARG F N   1 
ATOM   2113 C CA  . ARG A 1 304 ? 177.70700 348.78500 27.14300  1.000 18.70762  ? 339 ARG F CA  1 
ATOM   2114 C C   . ARG A 1 304 ? 177.52000 347.54600 26.31700  1.000 22.15838  ? 339 ARG F C   1 
ATOM   2115 O O   . ARG A 1 304 ? 178.32800 347.26600 25.43000  1.000 28.77577  ? 339 ARG F O   1 
ATOM   2116 C CB  . ARG A 1 304 ? 176.88400 349.95900 26.59500  1.000 23.00580  ? 339 ARG F CB  1 
ATOM   2117 C CG  . ARG A 1 304 ? 177.13400 350.37500 25.13700  1.000 19.27475  ? 339 ARG F CG  1 
ATOM   2118 C CD  . ARG A 1 304 ? 176.03800 351.27200 24.63900  1.000 29.85663  ? 339 ARG F CD  1 
ATOM   2119 N NE  . ARG A 1 304 ? 176.09800 352.62900 25.22500  1.000 40.02332  ? 339 ARG F NE  1 
ATOM   2120 C CZ  . ARG A 1 304 ? 176.61900 353.72500 24.67000  1.000 36.55639  ? 339 ARG F CZ  1 
ATOM   2121 N NH1 . ARG A 1 304 ? 177.17600 353.69800 23.46500  1.000 32.97185  ? 339 ARG F NH1 1 
ATOM   2122 N NH2 . ARG A 1 304 ? 176.51300 354.89400 25.31400  1.000 32.31713  ? 339 ARG F NH2 1 
ATOM   2123 N N   . GLY A 1 305 ? 176.56400 346.71800 26.72500  1.000 22.50091  ? 340 GLY F N   1 
ATOM   2124 C CA  . GLY A 1 305 ? 176.26400 345.49400 26.00600  1.000 19.52434  ? 340 GLY F CA  1 
ATOM   2125 C C   . GLY A 1 305 ? 175.79600 344.39500 26.94100  1.000 18.29740  ? 340 GLY F C   1 
ATOM   2126 O O   . GLY A 1 305 ? 175.37300 344.65800 28.05700  1.000 20.06052  ? 340 GLY F O   1 
ATOM   2127 N N   . TRP A 1 306 ? 176.00000 343.15600 26.48200  1.000 22.53924  ? 341 TRP F N   1 
ATOM   2128 C CA  . TRP A 1 306 ? 175.57300 341.94900 27.18500  1.000 22.96558  ? 341 TRP F CA  1 
ATOM   2129 C C   . TRP A 1 306 ? 176.72500 341.35300 27.99300  1.000 22.72868  ? 341 TRP F C   1 
ATOM   2130 O O   . TRP A 1 306 ? 177.81900 341.13000 27.45900  1.000 24.26512  ? 341 TRP F O   1 
ATOM   2131 C CB  . TRP A 1 306 ? 175.02000 340.91700 26.20700  1.000 22.45423  ? 341 TRP F CB  1 
ATOM   2132 C CG  . TRP A 1 306 ? 173.61400 341.18300 25.79500  1.000 21.46191  ? 341 TRP F CG  1 
ATOM   2133 C CD1 . TRP A 1 306 ? 173.19600 341.71000 24.60500  1.000 23.93701  ? 341 TRP F CD1 1 
ATOM   2134 C CD2 . TRP A 1 306 ? 172.43500 340.95800 26.56400  1.000 23.23096  ? 341 TRP F CD2 1 
ATOM   2135 N NE1 . TRP A 1 306 ? 171.82600 341.80800 24.57800  1.000 22.07797  ? 341 TRP F NE1 1 
ATOM   2136 C CE2 . TRP A 1 306 ? 171.33600 341.36000 25.77800  1.000 25.52285  ? 341 TRP F CE2 1 
ATOM   2137 C CE3 . TRP A 1 306 ? 172.19700 340.44900 27.83900  1.000 25.25447  ? 341 TRP F CE3 1 
ATOM   2138 C CZ2 . TRP A 1 306 ? 170.01900 341.27000 26.23500  1.000 28.81109  ? 341 TRP F CZ2 1 
ATOM   2139 C CZ3 . TRP A 1 306 ? 170.88400 340.37000 28.29600  1.000 25.51384  ? 341 TRP F CZ3 1 
ATOM   2140 C CH2 . TRP A 1 306 ? 169.81800 340.78400 27.50100  1.000 26.12502  ? 341 TRP F CH2 1 
ATOM   2141 N N   . TYR A 1 307 ? 176.43400 341.02100 29.24400  1.000 23.85475  ? 342 TYR F N   1 
ATOM   2142 C CA  . TYR A 1 307 ? 177.28700 340.32300 30.19100  1.000 21.40383  ? 342 TYR F CA  1 
ATOM   2143 C C   . TYR A 1 307 ? 176.64300 339.02700 30.67100  1.000 25.73919  ? 342 TYR F C   1 
ATOM   2144 O O   . TYR A 1 307 ? 175.42900 338.99200 30.91800  1.000 24.03212  ? 342 TYR F O   1 
ATOM   2145 C CB  . TYR A 1 307 ? 177.56000 341.19800 31.40200  1.000 21.88165  ? 342 TYR F CB  1 
ATOM   2146 C CG  . TYR A 1 307 ? 178.32500 342.45700 31.11300  1.000 21.86089  ? 342 TYR F CG  1 
ATOM   2147 C CD1 . TYR A 1 307 ? 177.70800 343.56900 30.52100  1.000 23.18312  ? 342 TYR F CD1 1 
ATOM   2148 C CD2 . TYR A 1 307 ? 179.66400 342.55400 31.46600  1.000 20.42546  ? 342 TYR F CD2 1 
ATOM   2149 C CE1 . TYR A 1 307 ? 178.42400 344.73500 30.28000  1.000 20.36600  ? 342 TYR F CE1 1 
ATOM   2150 C CE2 . TYR A 1 307 ? 180.38400 343.70500 31.21800  1.000 25.27064  ? 342 TYR F CE2 1 
ATOM   2151 C CZ  . TYR A 1 307 ? 179.75700 344.79200 30.63200  1.000 21.01517  ? 342 TYR F CZ  1 
ATOM   2152 O OH  . TYR A 1 307 ? 180.49700 345.91500 30.41400  1.000 16.60701  ? 342 TYR F OH  1 
ATOM   2153 N N   . CYS A 1 308 ? 177.41600 337.94000 30.69600  1.000 25.00887  ? 343 CYS F N   1 
ATOM   2154 C CA  . CYS A 1 308 ? 176.89900 336.67300 31.19600  1.000 24.76687  ? 343 CYS F CA  1 
ATOM   2155 C C   . CYS A 1 308 ? 177.91500 336.02400 32.09100  1.000 22.00781  ? 343 CYS F C   1 
ATOM   2156 O O   . CYS A 1 308 ? 179.10000 336.01400 31.76900  1.000 23.73445  ? 343 CYS F O   1 
ATOM   2157 C CB  . CYS A 1 308 ? 176.56400 335.67200 30.10200  1.000 27.54614  ? 343 CYS F CB  1 
ATOM   2158 S SG  . CYS A 1 308 ? 175.28700 336.24200 29.02400  1.000 40.22232  ? 343 CYS F SG  1 
ATOM   2159 N N   . ASP A 1 309 ? 177.43200 335.43900 33.18700  1.000 25.99102  ? 344 ASP F N   1 
ATOM   2160 C CA  . ASP A 1 309 ? 178.29500 334.64600 34.05200  1.000 21.46966  ? 344 ASP F CA  1 
ATOM   2161 C C   . ASP A 1 309 ? 178.75100 333.42000 33.27700  1.000 23.38799  ? 344 ASP F C   1 
ATOM   2162 O O   . ASP A 1 309 ? 177.94200 332.74100 32.62300  1.000 21.23544  ? 344 ASP F O   1 
ATOM   2163 C CB  . ASP A 1 309 ? 177.57500 334.22300 35.32600  1.000 23.05238  ? 344 ASP F CB  1 
ATOM   2164 C CG  . ASP A 1 309 ? 177.37000 335.36200 36.32100  1.000 33.49964  ? 344 ASP F CG  1 
ATOM   2165 O OD1 . ASP A 1 309 ? 178.25400 336.25800 36.45600  1.000 34.68760  ? 344 ASP F OD1 1 
ATOM   2166 O OD2 . ASP A 1 309 ? 176.34800 335.30400 37.04500  1.000 37.98302  ? 344 ASP F OD2 1 
ATOM   2167 N N   . ASN A 1 310 ? 180.05500 333.16000 33.31000  1.000 19.71427  ? 345 ASN F N   1 
ATOM   2168 C CA  . ASN A 1 310 ? 180.60900 332.07600 32.51700  1.000 18.54783  ? 345 ASN F CA  1 
ATOM   2169 C C   . ASN A 1 310 ? 181.86100 331.55500 33.19600  1.000 22.38991  ? 345 ASN F C   1 
ATOM   2170 O O   . ASN A 1 310 ? 182.85200 332.27800 33.28800  1.000 22.17833  ? 345 ASN F O   1 
ATOM   2171 C CB  . ASN A 1 310 ? 180.94200 332.57800 31.11500  1.000 23.99107  ? 345 ASN F CB  1 
ATOM   2172 C CG  . ASN A 1 310 ? 181.33100 331.46800 30.17500  1.000 27.08006  ? 345 ASN F CG  1 
ATOM   2173 O OD1 . ASN A 1 310 ? 181.19800 330.29200 30.52000  1.000 32.17905  ? 345 ASN F OD1 1 
ATOM   2174 N ND2 . ASN A 1 310 ? 181.80400 331.82300 28.97200  1.000 22.36389  ? 345 ASN F ND2 1 
ATOM   2175 N N   . ALA A 1 311 ? 181.76300 330.38700 33.82200  1.000 28.05682  ? 346 ALA F N   1 
ATOM   2176 C CA  . ALA A 1 311 ? 182.93500 329.65300 34.31400  1.000 21.25769  ? 346 ALA F CA  1 
ATOM   2177 C C   . ALA A 1 311 ? 183.80400 330.49200 35.24400  1.000 19.09470  ? 346 ALA F C   1 
ATOM   2178 O O   . ALA A 1 311 ? 185.02900 330.46800 35.14800  1.000 20.86531  ? 346 ALA F O   1 
ATOM   2179 C CB  . ALA A 1 311 ? 183.76300 329.11600 33.15300  1.000 18.28247  ? 346 ALA F CB  1 
ATOM   2180 N N   . GLY A 1 312 ? 183.18400 331.10300 36.24800  1.000 20.85566  ? 347 GLY F N   1 
ATOM   2181 C CA  . GLY A 1 312 ? 183.91200 331.89300 37.22300  1.000 20.06328  ? 347 GLY F CA  1 
ATOM   2182 C C   . GLY A 1 312 ? 184.32600 333.27100 36.79100  1.000 23.95775  ? 347 GLY F C   1 
ATOM   2183 O O   . GLY A 1 312 ? 184.84200 334.02700 37.62400  1.000 33.91045  ? 347 GLY F O   1 
ATOM   2184 N N   . SER A 1 313 ? 184.12900 333.63000 35.52600  1.000 28.89650  ? 348 SER F N   1 
ATOM   2185 C CA  . SER A 1 313 ? 184.39800 334.96100 34.99400  1.000 21.14490  ? 348 SER F CA  1 
ATOM   2186 C C   . SER A 1 313 ? 183.10800 335.46400 34.35500  1.000 20.57966  ? 348 SER F C   1 
ATOM   2187 O O   . SER A 1 313 ? 182.05400 334.82700 34.45800  1.000 23.04940  ? 348 SER F O   1 
ATOM   2188 C CB  . SER A 1 313 ? 185.57500 334.94400 34.02500  1.000 22.48106  ? 348 SER F CB  1 
ATOM   2189 O OG  . SER A 1 313 ? 186.75800 334.61400 34.73600  1.000 22.50364  ? 348 SER F OG  1 
ATOM   2190 N N   . VAL A 1 314 ? 183.18400 336.62400 33.71100  1.000 22.09633  ? 349 VAL F N   1 
ATOM   2191 C CA  . VAL A 1 314 ? 182.06200 337.21200 32.98400  1.000 20.72770  ? 349 VAL F CA  1 
ATOM   2192 C C   . VAL A 1 314 ? 182.40500 337.29300 31.50200  1.000 21.05384  ? 349 VAL F C   1 
ATOM   2193 O O   . VAL A 1 314 ? 183.46400 337.81500 31.13600  1.000 24.67399  ? 349 VAL F O   1 
ATOM   2194 C CB  . VAL A 1 314 ? 181.67000 338.59400 33.53200  1.000 22.45645  ? 349 VAL F CB  1 
ATOM   2195 C CG1 . VAL A 1 314 ? 180.58500 339.17300 32.64500  1.000 23.41124  ? 349 VAL F CG1 1 
ATOM   2196 C CG2 . VAL A 1 314 ? 181.19200 338.48700 34.98700  1.000 23.11074  ? 349 VAL F CG2 1 
ATOM   2197 N N   . SER A 1 315 ? 181.52700 336.78400 30.65300  1.000 21.47136  ? 350 SER F N   1 
ATOM   2198 C CA  . SER A 1 315 ? 181.69600 336.90000 29.21300  1.000 18.97494  ? 350 SER F CA  1 
ATOM   2199 C C   . SER A 1 315 ? 180.96700 338.15800 28.75800  1.000 24.32485  ? 350 SER F C   1 
ATOM   2200 O O   . SER A 1 315 ? 179.75700 338.29500 28.95300  1.000 25.37524  ? 350 SER F O   1 
ATOM   2201 C CB  . SER A 1 315 ? 181.10900 335.69200 28.50000  1.000 20.72519  ? 350 SER F CB  1 
ATOM   2202 O OG  . SER A 1 315 ? 181.93400 334.58300 28.68900  1.000 29.21791  ? 350 SER F OG  1 
ATOM   2203 N N   . PHE A 1 316 ? 181.72100 339.11000 28.24400  1.000 27.98175  ? 351 PHE F N   1 
ATOM   2204 C CA  . PHE A 1 316 ? 181.20000 340.36800 27.74100  1.000 21.52514  ? 351 PHE F CA  1 
ATOM   2205 C C   . PHE A 1 316 ? 181.09900 340.37400 26.22100  1.000 26.23325  ? 351 PHE F C   1 
ATOM   2206 O O   . PHE A 1 316 ? 182.03000 339.94800 25.53000  1.000 28.31459  ? 351 PHE F O   1 
ATOM   2207 C CB  . PHE A 1 316 ? 182.13300 341.46600 28.20000  1.000 22.34967  ? 351 PHE F CB  1 
ATOM   2208 C CG  . PHE A 1 316 ? 181.84400 342.76800 27.60300  1.000 24.69767  ? 351 PHE F CG  1 
ATOM   2209 C CD1 . PHE A 1 316 ? 180.59900 343.36200 27.78100  1.000 21.23118  ? 351 PHE F CD1 1 
ATOM   2210 C CD2 . PHE A 1 316 ? 182.82200 343.42900 26.86100  1.000 21.40887  ? 351 PHE F CD2 1 
ATOM   2211 C CE1 . PHE A 1 316 ? 180.33400 344.60300 27.20000  1.000 24.70006  ? 351 PHE F CE1 1 
ATOM   2212 C CE2 . PHE A 1 316 ? 182.56300 344.66400 26.30200  1.000 18.08844  ? 351 PHE F CE2 1 
ATOM   2213 C CZ  . PHE A 1 316 ? 181.32400 345.24800 26.45700  1.000 19.57632  ? 351 PHE F CZ  1 
ATOM   2214 N N   . PHE A 1 317 ? 179.97900 340.86100 25.69300  1.000 23.95332  ? 352 PHE F N   1 
ATOM   2215 C CA  . PHE A 1 317 ? 179.76700 340.89900 24.24700  1.000 24.12839  ? 352 PHE F CA  1 
ATOM   2216 C C   . PHE A 1 317 ? 179.64000 342.34000 23.80800  1.000 28.70722  ? 352 PHE F C   1 
ATOM   2217 O O   . PHE A 1 317 ? 178.52900 342.89800 23.79600  1.000 29.47271  ? 352 PHE F O   1 
ATOM   2218 C CB  . PHE A 1 317 ? 178.53200 340.08800 23.87200  1.000 24.43264  ? 352 PHE F CB  1 
ATOM   2219 C CG  . PHE A 1 317 ? 178.57700 338.69100 24.40700  1.000 29.34751  ? 352 PHE F CG  1 
ATOM   2220 C CD1 . PHE A 1 317 ? 178.08900 338.38800 25.67700  1.000 26.94226  ? 352 PHE F CD1 1 
ATOM   2221 C CD2 . PHE A 1 317 ? 179.07000 337.66000 23.61700  1.000 26.44428  ? 352 PHE F CD2 1 
ATOM   2222 C CE1 . PHE A 1 317 ? 178.15200 337.09700 26.16500  1.000 24.03468  ? 352 PHE F CE1 1 
ATOM   2223 C CE2 . PHE A 1 317 ? 179.11700 336.36800 24.09100  1.000 26.77086  ? 352 PHE F CE2 1 
ATOM   2224 C CZ  . PHE A 1 317 ? 178.65800 336.08100 25.36100  1.000 29.03264  ? 352 PHE F CZ  1 
ATOM   2225 N N   . PRO A 1 318 ? 180.71000 342.92900 23.28300  1.000 31.70452  ? 353 PRO F N   1 
ATOM   2226 C CA  . PRO A 1 318 ? 180.62600 344.34400 22.92000  1.000 28.47778  ? 353 PRO F CA  1 
ATOM   2227 C C   . PRO A 1 318 ? 179.80800 344.60100 21.66200  1.000 34.59601  ? 353 PRO F C   1 
ATOM   2228 O O   . PRO A 1 318 ? 179.05600 345.58200 21.65500  1.000 35.26668  ? 353 PRO F O   1 
ATOM   2229 C CB  . PRO A 1 318 ? 182.10400 344.75400 22.82700  1.000 23.85438  ? 353 PRO F CB  1 
ATOM   2230 C CG  . PRO A 1 318 ? 182.83000 343.52000 22.52500  1.000 25.99053  ? 353 PRO F CG  1 
ATOM   2231 C CD  . PRO A 1 318 ? 182.09300 342.41300 23.22200  1.000 26.59974  ? 353 PRO F CD  1 
ATOM   2232 N N   . GLN A 1 319 ? 179.89200 343.75800 20.62100  1.000 44.04494  ? 354 GLN F N   1 
ATOM   2233 C CA  . GLN A 1 319 ? 179.09000 343.96000 19.40500  1.000 44.29905  ? 354 GLN F CA  1 
ATOM   2234 C C   . GLN A 1 319 ? 177.62300 343.66200 19.70200  1.000 44.86601  ? 354 GLN F C   1 
ATOM   2235 O O   . GLN A 1 319 ? 177.30500 342.67600 20.36100  1.000 51.08751  ? 354 GLN F O   1 
ATOM   2236 C CB  . GLN A 1 319 ? 179.55900 343.05300 18.27000  1.000 49.28193  ? 354 GLN F CB  1 
ATOM   2237 C CG  . GLN A 1 319 ? 181.06200 342.95200 18.10400  1.000 57.06146  ? 354 GLN F CG  1 
ATOM   2238 C CD  . GLN A 1 319 ? 181.68600 344.29600 17.84400  1.000 63.30465  ? 354 GLN F CD  1 
ATOM   2239 O OE1 . GLN A 1 319 ? 181.10800 345.13000 17.13900  1.000 63.85850  ? 354 GLN F OE1 1 
ATOM   2240 N NE2 . GLN A 1 319 ? 182.86500 344.53300 18.43300  1.000 65.49588  ? 354 GLN F NE2 1 
ATOM   2241 N N   . ALA A 1 320 ? 176.71400 344.43500 19.10400  1.000 56.47896  ? 355 ALA F N   1 
ATOM   2242 C CA  . ALA A 1 320 ? 175.29500 344.33600 19.47400  1.000 60.06337  ? 355 ALA F CA  1 
ATOM   2243 C C   . ALA A 1 320 ? 174.57900 343.13500 18.86200  1.000 63.93550  ? 355 ALA F C   1 
ATOM   2244 O O   . ALA A 1 320 ? 173.66600 342.56800 19.47700  1.000 66.40927  ? 355 ALA F O   1 
ATOM   2245 C CB  . ALA A 1 320 ? 174.57000 345.61500 19.06500  1.000 56.65956  ? 355 ALA F CB  1 
ATOM   2246 N N   . GLU A 1 321 ? 175.00700 342.70500 17.69800  1.000 61.98893  ? 356 GLU F N   1 
ATOM   2247 C CA  . GLU A 1 321 ? 174.39600 341.62900 16.93600  1.000 63.53146  ? 356 GLU F CA  1 
ATOM   2248 C C   . GLU A 1 321 ? 174.90500 340.23400 17.29700  1.000 57.73763  ? 356 GLU F C   1 
ATOM   2249 O O   . GLU A 1 321 ? 174.46200 339.25100 16.69600  1.000 61.64937  ? 356 GLU F O   1 
ATOM   2250 C CB  . GLU A 1 321 ? 174.60600 341.95600 15.45000  1.000 66.21646  ? 356 GLU F CB  1 
ATOM   2251 C CG  . GLU A 1 321 ? 176.07000 341.84300 15.01300  1.000 63.71148  ? 356 GLU F CG  1 
ATOM   2252 C CD  . GLU A 1 321 ? 176.87400 343.10000 15.48200  1.000 73.88147  ? 356 GLU F CD  1 
ATOM   2253 O OE1 . GLU A 1 321 ? 176.23600 344.02400 16.07100  1.000 70.31519  ? 356 GLU F OE1 1 
ATOM   2254 O OE2 . GLU A 1 321 ? 178.11800 343.18000 15.26000  1.000 70.88834  ? 356 GLU F OE2 1 
ATOM   2255 N N   . THR A 1 322 ? 175.82400 340.11400 18.24200  1.000 55.24804  ? 357 THR F N   1 
ATOM   2256 C CA  . THR A 1 322 ? 176.31400 338.79900 18.62600  1.000 52.36399  ? 357 THR F CA  1 
ATOM   2257 C C   . THR A 1 322 ? 175.41300 338.10400 19.65700  1.000 50.83503  ? 357 THR F C   1 
ATOM   2258 O O   . THR A 1 322 ? 175.70800 336.96100 20.03600  1.000 49.55107  ? 357 THR F O   1 
ATOM   2259 C CB  . THR A 1 322 ? 177.77800 338.88000 19.11900  1.000 51.47362  ? 357 THR F CB  1 
ATOM   2260 O OG1 . THR A 1 322 ? 178.09900 337.73400 19.94300  1.000 47.58278  ? 357 THR F OG1 1 
ATOM   2261 C CG2 . THR A 1 322 ? 178.07800 340.19400 19.84400  1.000 44.94514  ? 357 THR F CG2 1 
ATOM   2262 N N   . CYS A 1 323 ? 174.31000 338.72700 20.08900  1.000 43.36281  ? 358 CYS F N   1 
ATOM   2263 C CA  . CYS A 1 323 ? 173.40600 338.11500 21.06600  1.000 37.66059  ? 358 CYS F CA  1 
ATOM   2264 C C   . CYS A 1 323 ? 171.95900 338.29900 20.63600  1.000 34.37166  ? 358 CYS F C   1 
ATOM   2265 O O   . CYS A 1 323 ? 171.48600 339.43400 20.52000  1.000 36.75388  ? 358 CYS F O   1 
ATOM   2266 C CB  . CYS A 1 323 ? 173.59400 338.70300 22.48500  1.000 31.19345  ? 358 CYS F CB  1 
ATOM   2267 S SG  . CYS A 1 323 ? 175.11300 338.25100 23.34000  1.000 40.36174  ? 358 CYS F SG  1 
ATOM   2268 N N   . LYS A 1 324 ? 171.27200 337.18700 20.39800  1.000 32.48018  ? 359 LYS F N   1 
ATOM   2269 C CA  . LYS A 1 324 ? 169.86900 337.17600 20.06300  1.000 31.96144  ? 359 LYS F CA  1 
ATOM   2270 C C   . LYS A 1 324 ? 169.03400 336.92800 21.30100  1.000 32.75657  ? 359 LYS F C   1 
ATOM   2271 O O   . LYS A 1 324 ? 169.38400 336.08500 22.12900  1.000 39.38661  ? 359 LYS F O   1 
ATOM   2272 C CB  . LYS A 1 324 ? 169.66600 336.10600 19.05300  1.000 31.94338  ? 359 LYS F CB  1 
ATOM   2273 C CG  . LYS A 1 324 ? 170.77600 336.03400 18.03100  1.000 33.55006  ? 359 LYS F CG  1 
ATOM   2274 C CD  . LYS A 1 324 ? 170.86300 337.32700 17.25600  1.000 29.57169  ? 359 LYS F CD  1 
ATOM   2275 C CE  . LYS A 1 324 ? 171.70100 337.15600 15.97900  1.000 44.52571  ? 359 LYS F CE  1 
ATOM   2276 N NZ  . LYS A 1 324 ? 172.04300 338.52000 15.45200  1.000 52.12451  ? 359 LYS F NZ  1 
ATOM   2277 N N   . VAL A 1 325 ? 167.96700 337.71200 21.44700  1.000 32.87747  ? 360 VAL F N   1 
ATOM   2278 C CA  . VAL A 1 325 ? 167.10900 337.69600 22.62300  1.000 32.74770  ? 360 VAL F CA  1 
ATOM   2279 C C   . VAL A 1 325 ? 165.72500 337.21100 22.24400  1.000 40.36477  ? 360 VAL F C   1 
ATOM   2280 O O   . VAL A 1 325 ? 165.14600 337.68700 21.26700  1.000 48.66483  ? 360 VAL F O   1 
ATOM   2281 C CB  . VAL A 1 325 ? 166.99200 339.11600 23.22100  1.000 33.34844  ? 360 VAL F CB  1 
ATOM   2282 C CG1 . VAL A 1 325 ? 166.16700 339.09800 24.48100  1.000 30.64855  ? 360 VAL F CG1 1 
ATOM   2283 C CG2 . VAL A 1 325 ? 168.35000 339.71100 23.49200  1.000 34.73629  ? 360 VAL F CG2 1 
ATOM   2284 N N   . GLN A 1 326 ? 165.18700 336.28600 23.03100  1.000 44.40132  ? 361 GLN F N   1 
ATOM   2285 C CA  . GLN A 1 326 ? 163.79900 335.83200 22.95900  1.000 45.92894  ? 361 GLN F CA  1 
ATOM   2286 C C   . GLN A 1 326 ? 163.23000 335.89000 24.37000  1.000 44.67947  ? 361 GLN F C   1 
ATOM   2287 O O   . GLN A 1 326 ? 163.66900 335.12800 25.23200  1.000 47.35720  ? 361 GLN F O   1 
ATOM   2288 C CB  . GLN A 1 326 ? 163.70000 334.42600 22.36000  1.000 46.02692  ? 361 GLN F CB  1 
ATOM   2289 C CG  . GLN A 1 326 ? 162.27900 333.91400 22.22800  1.000 62.86444  ? 361 GLN F CG  1 
ATOM   2290 C CD  . GLN A 1 326 ? 161.88100 333.03600 23.41000  1.000 72.94469  ? 361 GLN F CD  1 
ATOM   2291 O OE1 . GLN A 1 326 ? 160.79800 333.20900 23.97900  1.000 83.87383  ? 361 GLN F OE1 1 
ATOM   2292 N NE2 . GLN A 1 326 ? 162.75400 332.08200 23.78300  1.000 60.54894  ? 361 GLN F NE2 1 
ATOM   2293 N N   . SER A 1 327 ? 162.25800 336.76200 24.63100  1.000 48.06775  ? 362 SER F N   1 
ATOM   2294 C CA  . SER A 1 327 ? 161.71500 336.79200 25.99000  1.000 44.06351  ? 362 SER F CA  1 
ATOM   2295 C C   . SER A 1 327 ? 162.83500 336.96700 27.02300  1.000 41.50455  ? 362 SER F C   1 
ATOM   2296 O O   . SER A 1 327 ? 163.69400 337.82700 26.83500  1.000 39.63680  ? 362 SER F O   1 
ATOM   2297 C CB  . SER A 1 327 ? 160.92600 335.51000 26.25500  1.000 45.87848  ? 362 SER F CB  1 
ATOM   2298 O OG  . SER A 1 327 ? 159.91700 335.73400 27.22400  1.000 57.11702  ? 362 SER F OG  1 
ATOM   2299 N N   . ASN A 1 328 ? 162.76500 336.28300 28.17700  1.000 41.29062  ? 363 ASN F N   1 
ATOM   2300 C CA  . ASN A 1 328 ? 163.82800 336.24200 29.18800  1.000 33.25000  ? 363 ASN F CA  1 
ATOM   2301 C C   . ASN A 1 328 ? 165.14100 335.54500 28.74200  1.000 37.84575  ? 363 ASN F C   1 
ATOM   2302 O O   . ASN A 1 328 ? 166.04100 335.37800 29.58500  1.000 36.50967  ? 363 ASN F O   1 
ATOM   2303 C CB  . ASN A 1 328 ? 163.29100 335.63300 30.49000  1.000 37.42261  ? 363 ASN F CB  1 
ATOM   2304 C CG  . ASN A 1 328 ? 162.91400 334.17800 30.35200  1.000 46.59883  ? 363 ASN F CG  1 
ATOM   2305 O OD1 . ASN A 1 328 ? 162.21500 333.77600 29.41400  1.000 54.27379  ? 363 ASN F OD1 1 
ATOM   2306 N ND2 . ASN A 1 328 ? 163.37000 333.37100 31.29300  1.000 53.08784  ? 363 ASN F ND2 1 
ATOM   2307 N N   . ARG A 1 329 ? 165.31100 335.11700 27.48500  1.000 40.25105  ? 364 ARG F N   1 
ATOM   2308 C CA  . ARG A 1 329 ? 166.42900 334.25200 27.11400  1.000 32.92184  ? 364 ARG F CA  1 
ATOM   2309 C C   . ARG A 1 329 ? 167.37700 334.93800 26.13900  1.000 30.45137  ? 364 ARG F C   1 
ATOM   2310 O O   . ARG A 1 329 ? 166.94700 335.68800 25.27200  1.000 36.55789  ? 364 ARG F O   1 
ATOM   2311 C CB  . ARG A 1 329 ? 165.91900 332.95300 26.50300  1.000 33.32618  ? 364 ARG F CB  1 
ATOM   2312 C CG  . ARG A 1 329 ? 165.18900 332.08300 27.50600  1.000 38.65768  ? 364 ARG F CG  1 
ATOM   2313 C CD  . ARG A 1 329 ? 164.89200 330.69900 26.91800  1.000 56.07446  ? 364 ARG F CD  1 
ATOM   2314 N NE  . ARG A 1 329 ? 165.72600 329.66000 27.52000  1.000 59.58708  ? 364 ARG F NE  1 
ATOM   2315 C CZ  . ARG A 1 329 ? 165.71000 329.31900 28.80700  1.000 57.92642  ? 364 ARG F CZ  1 
ATOM   2316 N NH1 . ARG A 1 329 ? 164.86900 329.88200 29.67000  1.000 49.85824  ? 364 ARG F NH1 1 
ATOM   2317 N NH2 . ARG A 1 329 ? 166.55700 328.38600 29.24100  1.000 60.17609  ? 364 ARG F NH2 1 
ATOM   2318 N N   . VAL A 1 330 ? 168.67300 334.65300 26.25900  1.000 32.02203  ? 365 VAL F N   1 
ATOM   2319 C CA  . VAL A 1 330 ? 169.70200 335.27800 25.43300  1.000 29.21894  ? 365 VAL F CA  1 
ATOM   2320 C C   . VAL A 1 330 ? 170.57800 334.18000 24.85100  1.000 33.27546  ? 365 VAL F C   1 
ATOM   2321 O O   . VAL A 1 330 ? 170.98100 333.25600 25.56700  1.000 32.74573  ? 365 VAL F O   1 
ATOM   2322 C CB  . VAL A 1 330 ? 170.57000 336.26600 26.23500  1.000 28.66676  ? 365 VAL F CB  1 
ATOM   2323 C CG1 . VAL A 1 330 ? 171.31100 337.18800 25.30700  1.000 29.89790  ? 365 VAL F CG1 1 
ATOM   2324 C CG2 . VAL A 1 330 ? 169.72400 337.05300 27.18400  1.000 35.90764  ? 365 VAL F CG2 1 
ATOM   2325 N N   . PHE A 1 331 ? 170.92500 334.31400 23.56800  1.000 31.69877  ? 366 PHE F N   1 
ATOM   2326 C CA  . PHE A 1 331 ? 171.76400 333.35000 22.86300  1.000 31.39015  ? 366 PHE F CA  1 
ATOM   2327 C C   . PHE A 1 331 ? 173.00000 334.07400 22.32900  1.000 33.17744  ? 366 PHE F C   1 
ATOM   2328 O O   . PHE A 1 331 ? 172.90000 334.87900 21.40000  1.000 33.51591  ? 366 PHE F O   1 
ATOM   2329 C CB  . PHE A 1 331 ? 170.95700 332.71200 21.73700  1.000 30.97398  ? 366 PHE F CB  1 
ATOM   2330 C CG  . PHE A 1 331 ? 169.84300 331.84600 22.22400  1.000 31.60456  ? 366 PHE F CG  1 
ATOM   2331 C CD1 . PHE A 1 331 ? 168.64200 332.42700 22.59300  1.000 33.73620  ? 366 PHE F CD1 1 
ATOM   2332 C CD2 . PHE A 1 331 ? 169.97300 330.47000 22.32100  1.000 36.18881  ? 366 PHE F CD2 1 
ATOM   2333 C CE1 . PHE A 1 331 ? 167.59400 331.66300 23.05800  1.000 33.93342  ? 366 PHE F CE1 1 
ATOM   2334 C CE2 . PHE A 1 331 ? 168.91600 329.68800 22.77900  1.000 32.85555  ? 366 PHE F CE2 1 
ATOM   2335 C CZ  . PHE A 1 331 ? 167.73200 330.28900 23.14400  1.000 37.12582  ? 366 PHE F CZ  1 
ATOM   2336 N N   . CYS A 1 332 ? 174.14900 333.86200 22.95300  1.000 36.66237  ? 367 CYS F N   1 
ATOM   2337 C CA  . CYS A 1 332 ? 175.38800 334.53000 22.57600  1.000 31.48463  ? 367 CYS F CA  1 
ATOM   2338 C C   . CYS A 1 332 ? 176.38700 333.51700 22.02500  1.000 33.81885  ? 367 CYS F C   1 
ATOM   2339 O O   . CYS A 1 332 ? 176.28600 332.32600 22.28800  1.000 39.83268  ? 367 CYS F O   1 
ATOM   2340 C CB  . CYS A 1 332 ? 175.96900 335.25200 23.78900  1.000 26.97243  ? 367 CYS F CB  1 
ATOM   2341 S SG  . CYS A 1 332 ? 174.79600 336.49700 24.44000  1.000 38.62668  ? 367 CYS F SG  1 
ATOM   2342 N N   . ASP A 1 333 ? 177.38800 334.00900 21.29600  1.000 45.62505  ? 368 ASP F N   1 
ATOM   2343 C CA  . ASP A 1 333 ? 178.48600 333.20700 20.74700  1.000 43.64681  ? 368 ASP F CA  1 
ATOM   2344 C C   . ASP A 1 333 ? 179.76900 333.66700 21.41000  1.000 40.01381  ? 368 ASP F C   1 
ATOM   2345 O O   . ASP A 1 333 ? 180.20300 334.80200 21.18400  1.000 42.14236  ? 368 ASP F O   1 
ATOM   2346 C CB  . ASP A 1 333 ? 178.65000 333.40400 19.23300  1.000 40.78067  ? 368 ASP F CB  1 
ATOM   2347 C CG  . ASP A 1 333 ? 179.55300 332.33500 18.58600  1.000 49.57259  ? 368 ASP F CG  1 
ATOM   2348 O OD1 . ASP A 1 333 ? 179.85700 331.29400 19.20800  1.000 52.49716  ? 368 ASP F OD1 1 
ATOM   2349 O OD2 . ASP A 1 333 ? 180.04600 332.57400 17.46900  1.000 57.02538  ? 368 ASP F OD2 1 
ATOM   2350 N N   . THR A 1 334 ? 180.47100 332.74100 22.06000  1.000 34.32300  ? 369 THR F N   1 
ATOM   2351 C CA  . THR A 1 334 ? 181.67100 333.19800 22.73700  1.000 38.42055  ? 369 THR F CA  1 
ATOM   2352 C C   . THR A 1 334 ? 182.76500 333.56700 21.75100  1.000 40.18588  ? 369 THR F C   1 
ATOM   2353 O O   . THR A 1 334 ? 183.78200 334.14600 22.15200  1.000 37.20583  ? 369 THR F O   1 
ATOM   2354 C CB  . THR A 1 334 ? 182.17200 332.13300 23.72300  1.000 37.86439  ? 369 THR F CB  1 
ATOM   2355 O OG1 . THR A 1 334 ? 182.54500 330.93900 23.00500  1.000 47.86589  ? 369 THR F OG1 1 
ATOM   2356 C CG2 . THR A 1 334 ? 181.09600 331.78500 24.74400  1.000 27.93176  ? 369 THR F CG2 1 
ATOM   2357 N N   . MET A 1 335 ? 182.54700 333.31200 20.46500  1.000 39.75147  ? 370 MET F N   1 
ATOM   2358 C CA  . MET A 1 335 ? 183.54000 333.66900 19.46700  1.000 37.90508  ? 370 MET F CA  1 
ATOM   2359 C C   . MET A 1 335 ? 183.79400 335.16500 19.49400  1.000 44.80041  ? 370 MET F C   1 
ATOM   2360 O O   . MET A 1 335 ? 184.93300 335.61500 19.32100  1.000 51.65008  ? 370 MET F O   1 
ATOM   2361 C CB  . MET A 1 335 ? 183.06600 333.21000 18.09500  1.000 50.15380  ? 370 MET F CB  1 
ATOM   2362 C CG  . MET A 1 335 ? 183.95100 333.58000 16.91000  1.000 56.25013  ? 370 MET F CG  1 
ATOM   2363 S SD  . MET A 1 335 ? 185.26200 332.33400 16.79500  1.000 70.09062  ? 370 MET F SD  1 
ATOM   2364 C CE  . MET A 1 335 ? 184.27200 330.84900 16.57400  1.000 50.81654  ? 370 MET F CE  1 
ATOM   2365 N N   . ASN A 1 336 ? 182.74800 335.96100 19.72600  1.000 45.76925  ? 371 ASN F N   1 
ATOM   2366 C CA  . ASN A 1 336 ? 182.97000 337.39700 19.73200  1.000 49.35011  ? 371 ASN F CA  1 
ATOM   2367 C C   . ASN A 1 336 ? 182.68300 337.98700 21.11500  1.000 47.13195  ? 371 ASN F C   1 
ATOM   2368 O O   . ASN A 1 336 ? 181.79200 338.82700 21.28900  1.000 47.07811  ? 371 ASN F O   1 
ATOM   2369 C CB  . ASN A 1 336 ? 182.04400 338.01200 18.66600  1.000 55.76936  ? 371 ASN F CB  1 
ATOM   2370 C CG  . ASN A 1 336 ? 182.80500 338.58100 17.45200  1.000 65.51491  ? 371 ASN F CG  1 
ATOM   2371 O OD1 . ASN A 1 336 ? 183.88300 339.18200 17.59200  1.000 61.23816  ? 371 ASN F OD1 1 
ATOM   2372 N ND2 . ASN A 1 336 ? 182.23800 338.39000 16.25500  1.000 52.46766  ? 371 ASN F ND2 1 
ATOM   2373 N N   . SER A 1 337 ? 183.48200 337.57500 22.09800  1.000 41.49801  ? 372 SER F N   1 
ATOM   2374 C CA  . SER A 1 337 ? 183.35300 337.99600 23.48300  1.000 30.65272  ? 372 SER F CA  1 
ATOM   2375 C C   . SER A 1 337 ? 184.73500 338.28800 24.06000  1.000 28.01507  ? 372 SER F C   1 
ATOM   2376 O O   . SER A 1 337 ? 185.74800 337.73900 23.61300  1.000 32.16547  ? 372 SER F O   1 
ATOM   2377 C CB  . SER A 1 337 ? 182.61300 336.93800 24.30700  1.000 30.55719  ? 372 SER F CB  1 
ATOM   2378 O OG  . SER A 1 337 ? 183.34600 335.72300 24.29700  1.000 32.45527  ? 372 SER F OG  1 
ATOM   2379 N N   . LEU A 1 338 ? 184.75500 339.09100 25.11300  1.000 22.30318  ? 373 LEU F N   1 
ATOM   2380 C CA  . LEU A 1 338 ? 185.92400 339.26400 25.95400  1.000 23.23982  ? 373 LEU F CA  1 
ATOM   2381 C C   . LEU A 1 338 ? 185.64500 338.66600 27.32400  1.000 24.56279  ? 373 LEU F C   1 
ATOM   2382 O O   . LEU A 1 338 ? 184.51000 338.68300 27.81300  1.000 27.62343  ? 373 LEU F O   1 
ATOM   2383 C CB  . LEU A 1 338 ? 186.29200 340.74400 26.09000  1.000 30.91551  ? 373 LEU F CB  1 
ATOM   2384 C CG  . LEU A 1 338 ? 186.25900 341.55400 24.76900  1.000 28.78641  ? 373 LEU F CG  1 
ATOM   2385 C CD1 . LEU A 1 338 ? 186.29200 343.09300 25.03800  1.000 20.63963  ? 373 LEU F CD1 1 
ATOM   2386 C CD2 . LEU A 1 338 ? 187.37700 341.09900 23.81500  1.000 21.21517  ? 373 LEU F CD2 1 
ATOM   2387 N N   . THR A 1 339 ? 186.67700 338.11200 27.93500  1.000 26.20742  ? 374 THR F N   1 
ATOM   2388 C CA  . THR A 1 339 ? 186.54900 337.44500 29.22300  1.000 22.05031  ? 374 THR F CA  1 
ATOM   2389 C C   . THR A 1 339 ? 187.03800 338.43100 30.27200  1.000 21.62736  ? 374 THR F C   1 
ATOM   2390 O O   . THR A 1 339 ? 188.22100 338.79100 30.28500  1.000 29.69773  ? 374 THR F O   1 
ATOM   2391 C CB  . THR A 1 339 ? 187.35200 336.15100 29.25900  1.000 23.03416  ? 374 THR F CB  1 
ATOM   2392 O OG1 . THR A 1 339 ? 186.93600 335.32100 28.16800  1.000 26.08905  ? 374 THR F OG1 1 
ATOM   2393 C CG2 . THR A 1 339 ? 187.03300 335.40000 30.54000  1.000 23.64734  ? 374 THR F CG2 1 
ATOM   2394 N N   . LEU A 1 340 ? 186.15800 338.80600 31.18600  1.000 20.10615  ? 375 LEU F N   1 
ATOM   2395 C CA  . LEU A 1 340 ? 186.44700 339.78100 32.21900  1.000 21.85174  ? 375 LEU F CA  1 
ATOM   2396 C C   . LEU A 1 340 ? 186.27800 339.17500 33.60200  1.000 21.36671  ? 375 LEU F C   1 
ATOM   2397 O O   . LEU A 1 340 ? 185.52700 338.21000 33.76700  1.000 22.06004  ? 375 LEU F O   1 
ATOM   2398 C CB  . LEU A 1 340 ? 185.45400 340.94400 32.09000  1.000 25.31911  ? 375 LEU F CB  1 
ATOM   2399 C CG  . LEU A 1 340 ? 185.28200 341.70900 30.77800  1.000 24.37756  ? 375 LEU F CG  1 
ATOM   2400 C CD1 . LEU A 1 340 ? 184.19800 342.72200 30.97500  1.000 24.12406  ? 375 LEU F CD1 1 
ATOM   2401 C CD2 . LEU A 1 340 ? 186.55300 342.40800 30.39300  1.000 21.64572  ? 375 LEU F CD2 1 
ATOM   2402 N N   . PRO A 1 341 ? 186.98700 339.68400 34.61000  1.000 23.44322  ? 376 PRO F N   1 
ATOM   2403 C CA  . PRO A 1 341 ? 186.74100 339.21400 35.97800  1.000 19.99649  ? 376 PRO F CA  1 
ATOM   2404 C C   . PRO A 1 341 ? 185.34200 339.55200 36.44700  1.000 21.07235  ? 376 PRO F C   1 
ATOM   2405 O O   . PRO A 1 341 ? 184.77700 340.58400 36.09000  1.000 31.39254  ? 376 PRO F O   1 
ATOM   2406 C CB  . PRO A 1 341 ? 187.79800 339.96000 36.79600  1.000 19.67885  ? 376 PRO F CB  1 
ATOM   2407 C CG  . PRO A 1 341 ? 188.16300 341.12800 35.99700  1.000 17.03321  ? 376 PRO F CG  1 
ATOM   2408 C CD  . PRO A 1 341 ? 188.06600 340.68200 34.56200  1.000 23.51995  ? 376 PRO F CD  1 
ATOM   2409 N N   . SER A 1 342 ? 184.80400 338.70600 37.32000  1.000 26.71339  ? 377 SER F N   1 
ATOM   2410 C CA  . SER A 1 342 ? 183.44400 338.90300 37.81700  1.000 24.69540  ? 377 SER F CA  1 
ATOM   2411 C C   . SER A 1 342 ? 183.30800 340.19200 38.60400  1.000 26.04276  ? 377 SER F C   1 
ATOM   2412 O O   . SER A 1 342 ? 182.17900 340.67100 38.79500  1.000 29.81683  ? 377 SER F O   1 
ATOM   2413 C CB  . SER A 1 342 ? 182.97800 337.70500 38.66700  1.000 21.52768  ? 377 SER F CB  1 
ATOM   2414 O OG  . SER A 1 342 ? 183.82200 337.52200 39.78600  1.000 36.43515  ? 377 SER F OG  1 
ATOM   2415 N N   . GLU A 1 343 ? 184.42200 340.80900 38.98300  1.000 25.18615  ? 378 GLU F N   1 
ATOM   2416 C CA  . GLU A 1 343 ? 184.35100 342.07600 39.69900  1.000 29.53611  ? 378 GLU F CA  1 
ATOM   2417 C C   . GLU A 1 343 ? 183.89800 343.21400 38.78400  1.000 32.76834  ? 378 GLU F C   1 
ATOM   2418 O O   . GLU A 1 343 ? 183.66600 344.32200 39.27500  1.000 34.64679  ? 378 GLU F O   1 
ATOM   2419 C CB  . GLU A 1 343 ? 185.71200 342.44700 40.31300  1.000 33.32509  ? 378 GLU F CB  1 
ATOM   2420 C CG  . GLU A 1 343 ? 186.17900 341.63000 41.52900  1.000 30.19422  ? 378 GLU F CG  1 
ATOM   2421 C CD  . GLU A 1 343 ? 186.48800 340.16900 41.18000  1.000 35.67003  ? 378 GLU F CD  1 
ATOM   2422 O OE1 . GLU A 1 343 ? 187.00700 339.87600 40.06000  1.000 31.63042  ? 378 GLU F OE1 1 
ATOM   2423 O OE2 . GLU A 1 343 ? 186.18000 339.30200 42.02900  1.000 37.47433  ? 378 GLU F OE2 1 
ATOM   2424 N N   . VAL A 1 344 ? 183.75100 342.96600 37.47300  1.000 31.16703  ? 379 VAL F N   1 
ATOM   2425 C CA  . VAL A 1 344 ? 183.33200 344.03000 36.56800  1.000 33.33218  ? 379 VAL F CA  1 
ATOM   2426 C C   . VAL A 1 344 ? 181.90500 344.45400 36.90600  1.000 32.64093  ? 379 VAL F C   1 
ATOM   2427 O O   . VAL A 1 344 ? 181.51100 345.60200 36.65700  1.000 27.04598  ? 379 VAL F O   1 
ATOM   2428 C CB  . VAL A 1 344 ? 183.42700 343.57600 35.10000  1.000 28.22842  ? 379 VAL F CB  1 
ATOM   2429 C CG1 . VAL A 1 344 ? 182.30800 342.60900 34.77200  1.000 25.18483  ? 379 VAL F CG1 1 
ATOM   2430 C CG2 . VAL A 1 344 ? 183.48300 344.75300 34.16600  1.000 24.71669  ? 379 VAL F CG2 1 
ATOM   2431 N N   . ASN A 1 345 ? 181.15600 343.58200 37.58000  1.000 32.59242  ? 380 ASN F N   1 
ATOM   2432 C CA  . ASN A 1 345 ? 179.80000 343.90600 37.97800  1.000 28.93648  ? 380 ASN F CA  1 
ATOM   2433 C C   . ASN A 1 345 ? 179.80000 344.94600 39.06400  1.000 32.42020  ? 380 ASN F C   1 
ATOM   2434 O O   . ASN A 1 345 ? 178.75700 345.54200 39.34300  1.000 34.57272  ? 380 ASN F O   1 
ATOM   2435 C CB  . ASN A 1 345 ? 179.03900 342.69100 38.48600  1.000 32.92899  ? 380 ASN F CB  1 
ATOM   2436 C CG  . ASN A 1 345 ? 177.63800 343.05900 39.01500  1.000 39.73342  ? 380 ASN F CG  1 
ATOM   2437 O OD1 . ASN A 1 345 ? 176.71500 343.41000 38.24500  1.000 37.32729  ? 380 ASN F OD1 1 
ATOM   2438 N ND2 . ASN A 1 345 ? 177.49000 343.02000 40.34800  1.000 36.07890  ? 380 ASN F ND2 1 
ATOM   2439 N N   . LEU A 1 346 ? 180.94100 345.18600 39.68400  1.000 33.89465  ? 381 LEU F N   1 
ATOM   2440 C CA  . LEU A 1 346 ? 180.92000 346.16700 40.74200  1.000 33.51356  ? 381 LEU F CA  1 
ATOM   2441 C C   . LEU A 1 346 ? 180.90000 347.61000 40.21600  1.000 33.75622  ? 381 LEU F C   1 
ATOM   2442 O O   . LEU A 1 346 ? 180.61200 348.53700 40.98500  1.000 37.66278  ? 381 LEU F O   1 
ATOM   2443 C CB  . LEU A 1 346 ? 182.21500 345.92100 41.52100  1.000 34.87661  ? 381 LEU F CB  1 
ATOM   2444 C CG  . LEU A 1 346 ? 182.13400 344.85000 42.59700  1.000 30.65521  ? 381 LEU F CG  1 
ATOM   2445 C CD1 . LEU A 1 346 ? 183.51400 344.70200 43.18500  1.000 26.02210  ? 381 LEU F CD1 1 
ATOM   2446 C CD2 . LEU A 1 346 ? 181.00700 345.06800 43.62500  1.000 26.34198  ? 381 LEU F CD2 1 
ATOM   2447 N N   . CYS A 1 347 ? 181.01000 347.81800 38.90400  1.000 33.31506  ? 382 CYS F N   1 
ATOM   2448 C CA  . CYS A 1 347 ? 180.85300 349.16600 38.38800  1.000 32.32930  ? 382 CYS F CA  1 
ATOM   2449 C C   . CYS A 1 347 ? 179.39600 349.57700 38.48300  1.000 35.60768  ? 382 CYS F C   1 
ATOM   2450 O O   . CYS A 1 347 ? 179.07300 350.76400 38.35700  1.000 37.84799  ? 382 CYS F O   1 
ATOM   2451 C CB  . CYS A 1 347 ? 181.28500 349.23200 36.92400  1.000 26.83427  ? 382 CYS F CB  1 
ATOM   2452 S SG  . CYS A 1 347 ? 183.03600 348.94700 36.68300  1.000 40.11209  ? 382 CYS F SG  1 
ATOM   2453 N N   . ASN A 1 348 ? 178.51200 348.58900 38.57800  1.000 29.38706  ? 383 ASN F N   1 
ATOM   2454 C CA  . ASN A 1 348 ? 177.09700 348.82300 38.71700  1.000 32.03345  ? 383 ASN F CA  1 
ATOM   2455 C C   . ASN A 1 348 ? 176.66700 349.14900 40.13000  1.000 36.63811  ? 383 ASN F C   1 
ATOM   2456 O O   . ASN A 1 348 ? 175.53900 349.60100 40.30700  1.000 46.04317  ? 383 ASN F O   1 
ATOM   2457 C CB  . ASN A 1 348 ? 176.29700 347.68900 38.12000  1.000 31.99621  ? 383 ASN F CB  1 
ATOM   2458 C CG  . ASN A 1 348 ? 176.77100 347.37300 36.74000  1.000 32.93242  ? 383 ASN F CG  1 
ATOM   2459 O OD1 . ASN A 1 348 ? 176.61000 348.19600 35.80900  1.000 31.29271  ? 383 ASN F OD1 1 
ATOM   2460 N ND2 . ASN A 1 348 ? 177.23900 346.14400 36.54800  1.000 31.49624  ? 383 ASN F ND2 1 
ATOM   2461 N N   . VAL A 1 349 ? 177.38900 348.74800 41.16600  1.000 36.67231  ? 384 VAL F N   1 
ATOM   2462 C CA  . VAL A 1 349 ? 176.94100 349.11700 42.49300  1.000 41.30332  ? 384 VAL F CA  1 
ATOM   2463 C C   . VAL A 1 349 ? 177.81100 350.20300 43.13000  1.000 40.48002  ? 384 VAL F C   1 
ATOM   2464 O O   . VAL A 1 349 ? 177.28400 351.04400 43.87000  1.000 38.78795  ? 384 VAL F O   1 
ATOM   2465 C CB  . VAL A 1 349 ? 176.87300 347.86700 43.39300  1.000 37.59685  ? 384 VAL F CB  1 
ATOM   2466 C CG1 . VAL A 1 349 ? 176.09700 346.77700 42.67100  1.000 41.68992  ? 384 VAL F CG1 1 
ATOM   2467 C CG2 . VAL A 1 349 ? 178.24600 347.39600 43.75300  1.000 29.83193  ? 384 VAL F CG2 1 
ATOM   2468 N N   . ASP A 1 350 ? 179.10900 350.24400 42.83400  1.000 34.79781  ? 385 ASP F N   1 
ATOM   2469 C CA  . ASP A 1 350 ? 180.00100 351.26500 43.39400  1.000 41.30871  ? 385 ASP F CA  1 
ATOM   2470 C C   . ASP A 1 350 ? 181.03600 351.57200 42.30700  1.000 41.11134  ? 385 ASP F C   1 
ATOM   2471 O O   . ASP A 1 350 ? 182.07000 350.89800 42.26100  1.000 41.07575  ? 385 ASP F O   1 
ATOM   2472 C CB  . ASP A 1 350 ? 180.62600 350.88300 44.72700  1.000 42.28453  ? 385 ASP F CB  1 
ATOM   2473 C CG  . ASP A 1 350 ? 181.48500 352.02300 45.30700  1.000 51.83804  ? 385 ASP F CG  1 
ATOM   2474 O OD1 . ASP A 1 350 ? 181.49100 353.13600 44.68900  1.000 49.22505  ? 385 ASP F OD1 1 
ATOM   2475 O OD2 . ASP A 1 350 ? 182.13700 351.80900 46.36900  1.000 49.48361  ? 385 ASP F OD2 1 
ATOM   2476 N N   . ILE A 1 351 ? 180.88000 352.67000 41.57000  1.000 35.52618  ? 386 ILE F N   1 
ATOM   2477 C CA  . ILE A 1 351 ? 181.79100 352.84800 40.44000  1.000 38.50447  ? 386 ILE F CA  1 
ATOM   2478 C C   . ILE A 1 351 ? 183.17300 353.28000 40.92300  1.000 33.92028  ? 386 ILE F C   1 
ATOM   2479 O O   . ILE A 1 351 ? 184.14900 353.17100 40.17100  1.000 34.79981  ? 386 ILE F O   1 
ATOM   2480 C CB  . ILE A 1 351 ? 181.18000 353.85300 39.43700  1.000 38.45984  ? 386 ILE F CB  1 
ATOM   2481 C CG1 . ILE A 1 351 ? 181.92600 353.84100 38.10200  1.000 36.40422  ? 386 ILE F CG1 1 
ATOM   2482 C CG2 . ILE A 1 351 ? 181.25100 355.28500 39.97500  1.000 26.07177  ? 386 ILE F CG2 1 
ATOM   2483 C CD1 . ILE A 1 351 ? 181.28800 354.75700 37.05400  1.000 27.03912  ? 386 ILE F CD1 1 
ATOM   2484 N N   . PHE A 1 352 ? 183.26400 353.81900 42.12800  1.000 41.56711  ? 387 PHE F N   1 
ATOM   2485 C CA  . PHE A 1 352 ? 184.46400 354.30200 42.81500  1.000 40.31638  ? 387 PHE F CA  1 
ATOM   2486 C C   . PHE A 1 352 ? 185.17800 353.17400 43.58700  1.000 40.20016  ? 387 PHE F C   1 
ATOM   2487 O O   . PHE A 1 352 ? 186.16500 353.43900 44.26900  1.000 49.70861  ? 387 PHE F O   1 
ATOM   2488 C CB  . PHE A 1 352 ? 184.12900 355.48100 43.71600  1.000 39.04947  ? 387 PHE F CB  1 
ATOM   2489 C CG  . PHE A 1 352 ? 183.85900 356.73000 42.95300  1.000 33.14636  ? 387 PHE F CG  1 
ATOM   2490 C CD1 . PHE A 1 352 ? 184.69600 357.10000 41.92600  1.000 35.76225  ? 387 PHE F CD1 1 
ATOM   2491 C CD2 . PHE A 1 352 ? 182.72500 357.47400 43.18700  1.000 34.97819  ? 387 PHE F CD2 1 
ATOM   2492 C CE1 . PHE A 1 352 ? 184.43900 358.23000 41.18500  1.000 36.47331  ? 387 PHE F CE1 1 
ATOM   2493 C CE2 . PHE A 1 352 ? 182.45800 358.60100 42.45300  1.000 35.76274  ? 387 PHE F CE2 1 
ATOM   2494 C CZ  . PHE A 1 352 ? 183.31800 358.97800 41.44300  1.000 36.33108  ? 387 PHE F CZ  1 
ATOM   2495 N N   . ASN A 1 353 ? 184.82900 351.92300 43.33400  1.000 38.79677  ? 388 ASN F N   1 
ATOM   2496 C CA  . ASN A 1 353 ? 185.28500 350.72500 44.04400  1.000 40.30133  ? 388 ASN F CA  1 
ATOM   2497 C C   . ASN A 1 353 ? 186.66800 350.28400 43.58200  1.000 39.51429  ? 388 ASN F C   1 
ATOM   2498 O O   . ASN A 1 353 ? 186.95600 350.29500 42.38900  1.000 44.91298  ? 388 ASN F O   1 
ATOM   2499 C CB  . ASN A 1 353 ? 184.32300 349.57300 43.77600  1.000 39.30254  ? 388 ASN F CB  1 
ATOM   2500 C CG  . ASN A 1 353 ? 184.63900 348.84300 42.44300  1.000 42.47174  ? 388 ASN F CG  1 
ATOM   2501 O OD1 . ASN A 1 353 ? 185.40400 347.86800 42.40700  1.000 44.08859  ? 388 ASN F OD1 1 
ATOM   2502 N ND2 . ASN A 1 353 ? 184.06800 349.33700 41.34600  1.000 41.12656  ? 388 ASN F ND2 1 
ATOM   2503 N N   . PRO A 1 354 ? 187.61900 350.13900 44.50300  1.000 46.10703  ? 389 PRO F N   1 
ATOM   2504 C CA  . PRO A 1 354 ? 188.95400 349.73300 44.07500  1.000 52.32261  ? 389 PRO F CA  1 
ATOM   2505 C C   . PRO A 1 354 ? 189.08700 348.29300 43.55300  1.000 49.59022  ? 389 PRO F C   1 
ATOM   2506 O O   . PRO A 1 354 ? 190.18400 347.96200 43.07500  1.000 53.09576  ? 389 PRO F O   1 
ATOM   2507 C CB  . PRO A 1 354 ? 189.76200 349.90900 45.36700  1.000 35.87827  ? 389 PRO F CB  1 
ATOM   2508 C CG  . PRO A 1 354 ? 188.74800 349.38100 46.42400  1.000 33.37264  ? 389 PRO F CG  1 
ATOM   2509 C CD  . PRO A 1 354 ? 187.36800 349.75800 45.91300  1.000 39.60501  ? 389 PRO F CD  1 
ATOM   2510 N N   . LYS A 1 355 ? 188.10700 347.38400 43.67300  1.000 37.05797  ? 390 LYS F N   1 
ATOM   2511 C CA  . LYS A 1 355 ? 188.46900 346.09700 43.09100  1.000 38.66468  ? 390 LYS F CA  1 
ATOM   2512 C C   . LYS A 1 355 ? 188.51500 346.09800 41.55500  1.000 42.64106  ? 390 LYS F C   1 
ATOM   2513 O O   . LYS A 1 355 ? 189.34400 345.38400 40.97200  1.000 37.85894  ? 390 LYS F O   1 
ATOM   2514 C CB  . LYS A 1 355 ? 187.53600 344.99600 43.57200  1.000 38.70300  ? 390 LYS F CB  1 
ATOM   2515 C CG  . LYS A 1 355 ? 187.67800 344.69900 45.03700  1.000 38.41116  ? 390 LYS F CG  1 
ATOM   2516 C CD  . LYS A 1 355 ? 186.75100 343.60300 45.44600  1.000 42.31965  ? 390 LYS F CD  1 
ATOM   2517 C CE  . LYS A 1 355 ? 186.92600 343.31600 46.90800  1.000 52.79422  ? 390 LYS F CE  1 
ATOM   2518 N NZ  . LYS A 1 355 ? 186.01700 342.22200 47.29300  1.000 64.30875  ? 390 LYS F NZ  1 
ATOM   2519 N N   . TYR A 1 356 ? 187.71800 346.93800 40.87300  1.000 43.10486  ? 391 TYR F N   1 
ATOM   2520 C CA  . TYR A 1 356 ? 187.77200 347.01500 39.40900  1.000 38.19364  ? 391 TYR F CA  1 
ATOM   2521 C C   . TYR A 1 356 ? 187.79300 348.46100 38.93800  1.000 34.54294  ? 391 TYR F C   1 
ATOM   2522 O O   . TYR A 1 356 ? 186.94000 349.25300 39.33400  1.000 40.52152  ? 391 TYR F O   1 
ATOM   2523 C CB  . TYR A 1 356 ? 186.60200 346.23200 38.74800  1.000 33.83324  ? 391 TYR F CB  1 
ATOM   2524 C CG  . TYR A 1 356 ? 186.63800 346.12100 37.21700  1.000 33.98480  ? 391 TYR F CG  1 
ATOM   2525 C CD1 . TYR A 1 356 ? 186.17600 347.14800 36.40600  1.000 31.86071  ? 391 TYR F CD1 1 
ATOM   2526 C CD2 . TYR A 1 356 ? 187.10800 344.96700 36.58200  1.000 39.39279  ? 391 TYR F CD2 1 
ATOM   2527 C CE1 . TYR A 1 356 ? 186.20400 347.04200 35.00500  1.000 35.10931  ? 391 TYR F CE1 1 
ATOM   2528 C CE2 . TYR A 1 356 ? 187.14000 344.85100 35.17700  1.000 31.42531  ? 391 TYR F CE2 1 
ATOM   2529 C CZ  . TYR A 1 356 ? 186.68300 345.89400 34.39100  1.000 39.07596  ? 391 TYR F CZ  1 
ATOM   2530 O OH  . TYR A 1 356 ? 186.70400 345.80900 32.99400  1.000 40.77016  ? 391 TYR F OH  1 
ATOM   2531 N N   . ASP A 1 357 ? 188.69600 348.76800 38.03000  1.000 36.80521  ? 392 ASP F N   1 
ATOM   2532 C CA  . ASP A 1 357 ? 188.94200 350.08100 37.42400  1.000 31.84707  ? 392 ASP F CA  1 
ATOM   2533 C C   . ASP A 1 357 ? 187.82400 350.30400 36.40700  1.000 34.69144  ? 392 ASP F C   1 
ATOM   2534 O O   . ASP A 1 357 ? 188.01600 350.08100 35.20400  1.000 39.06173  ? 392 ASP F O   1 
ATOM   2535 C CB  . ASP A 1 357 ? 190.32400 350.19100 36.82200  1.000 40.94845  ? 392 ASP F CB  1 
ATOM   2536 C CG  . ASP A 1 357 ? 190.70500 351.62800 36.58800  1.000 45.83736  ? 392 ASP F CG  1 
ATOM   2537 O OD1 . ASP A 1 357 ? 190.09000 352.51900 37.25800  1.000 39.10852  ? 392 ASP F OD1 1 
ATOM   2538 O OD2 . ASP A 1 357 ? 191.61900 351.85200 35.75800  1.000 46.47838  ? 392 ASP F OD2 1 
ATOM   2539 N N   . CYS A 1 358 ? 186.70100 350.88500 36.83500  1.000 32.42563  ? 393 CYS F N   1 
ATOM   2540 C CA  . CYS A 1 358 ? 185.61800 351.12800 35.88400  1.000 32.23629  ? 393 CYS F CA  1 
ATOM   2541 C C   . CYS A 1 358 ? 185.92300 352.18200 34.84500  1.000 32.04726  ? 393 CYS F C   1 
ATOM   2542 O O   . CYS A 1 358 ? 186.51200 353.23200 35.11000  1.000 37.02514  ? 393 CYS F O   1 
ATOM   2543 C CB  . CYS A 1 358 ? 184.37100 351.57600 36.64100  1.000 29.14194  ? 393 CYS F CB  1 
ATOM   2544 S SG  . CYS A 1 358 ? 183.89000 350.39000 37.89400  1.000 41.66980  ? 393 CYS F SG  1 
ATOM   2545 N N   . LYS A 1 359 ? 185.52400 351.84100 33.61900  1.000 33.61539  ? 394 LYS F N   1 
ATOM   2546 C CA  . LYS A 1 359 ? 185.93200 352.58800 32.45500  1.000 35.43027  ? 394 LYS F CA  1 
ATOM   2547 C C   . LYS A 1 359 ? 184.91400 353.67300 32.12300  1.000 33.25415  ? 394 LYS F C   1 
ATOM   2548 O O   . LYS A 1 359 ? 183.70100 353.42300 32.10800  1.000 35.70130  ? 394 LYS F O   1 
ATOM   2549 C CB  . LYS A 1 359 ? 185.95600 351.55800 31.31000  1.000 34.38728  ? 394 LYS F CB  1 
ATOM   2550 C CG  . LYS A 1 359 ? 186.93700 350.35600 31.50600  1.000 34.67553  ? 394 LYS F CG  1 
ATOM   2551 C CD  . LYS A 1 359 ? 188.05100 350.29000 30.49300  1.000 45.57530  ? 394 LYS F CD  1 
ATOM   2552 C CE  . LYS A 1 359 ? 189.11900 351.34100 30.85700  1.000 51.72076  ? 394 LYS F CE  1 
ATOM   2553 N NZ  . LYS A 1 359 ? 190.21900 351.50700 29.84500  1.000 54.58723  ? 394 LYS F NZ  1 
ATOM   2554 N N   . ILE A 1 360 ? 185.41900 354.83900 31.71500  1.000 30.77739  ? 395 ILE F N   1 
ATOM   2555 C CA  . ILE A 1 360 ? 184.58400 355.97000 31.33100  1.000 30.26767  ? 395 ILE F CA  1 
ATOM   2556 C C   . ILE A 1 360 ? 185.19500 356.66600 30.11900  1.000 31.21764  ? 395 ILE F C   1 
ATOM   2557 O O   . ILE A 1 360 ? 186.40800 356.65500 29.90400  1.000 29.07070  ? 395 ILE F O   1 
ATOM   2558 C CB  . ILE A 1 360 ? 184.35000 356.95200 32.50800  1.000 28.67232  ? 395 ILE F CB  1 
ATOM   2559 C CG1 . ILE A 1 360 ? 185.66500 357.57700 32.96800  1.000 29.19816  ? 395 ILE F CG1 1 
ATOM   2560 C CG2 . ILE A 1 360 ? 183.60000 356.29500 33.64300  1.000 24.22646  ? 395 ILE F CG2 1 
ATOM   2561 C CD1 . ILE A 1 360 ? 185.47400 358.78200 33.82200  1.000 29.53366  ? 395 ILE F CD1 1 
ATOM   2562 N N   . MET A 1 361 ? 184.39400 357.50800 29.51700  1.000 31.60633  ? 396 MET F N   1 
ATOM   2563 C CA  . MET A 1 361 ? 184.84000 358.40100 28.47800  1.000 30.63850  ? 396 MET F CA  1 
ATOM   2564 C C   . MET A 1 361 ? 184.41900 359.82200 28.81600  1.000 29.55799  ? 396 MET F C   1 
ATOM   2565 O O   . MET A 1 361 ? 183.39300 360.02300 29.46800  1.000 34.89784  ? 396 MET F O   1 
ATOM   2566 C CB  . MET A 1 361 ? 184.22600 357.89400 27.17800  1.000 30.88405  ? 396 MET F CB  1 
ATOM   2567 C CG  . MET A 1 361 ? 184.57900 358.70600 25.97600  1.000 52.67730  ? 396 MET F CG  1 
ATOM   2568 S SD  . MET A 1 361 ? 183.09500 359.57900 25.43100  1.000 57.57486  ? 396 MET F SD  1 
ATOM   2569 C CE  . MET A 1 361 ? 182.03100 358.15500 25.12100  1.000 56.27589  ? 396 MET F CE  1 
ATOM   2570 N N   . THR A 1 362 ? 185.24000 360.80100 28.44400  1.000 23.74324  ? 397 THR F N   1 
ATOM   2571 C CA  . THR A 1 362 ? 184.94600 362.18100 28.79600  1.000 30.86143  ? 397 THR F CA  1 
ATOM   2572 C C   . THR A 1 362 ? 184.85800 363.03800 27.53900  1.000 33.62643  ? 397 THR F C   1 
ATOM   2573 O O   . THR A 1 362 ? 185.29100 362.65700 26.45300  1.000 41.07024  ? 397 THR F O   1 
ATOM   2574 C CB  . THR A 1 362 ? 185.98800 362.78800 29.76700  1.000 28.37097  ? 397 THR F CB  1 
ATOM   2575 O OG1 . THR A 1 362 ? 187.28400 362.79200 29.17000  1.000 30.98631  ? 397 THR F OG1 1 
ATOM   2576 C CG2 . THR A 1 362 ? 186.09400 361.94500 31.01900  1.000 28.34854  ? 397 THR F CG2 1 
ATOM   2577 N N   . SER A 1 363 ? 184.13700 364.12900 27.65800  1.000 37.68385  ? 398 SER F N   1 
ATOM   2578 C CA  . SER A 1 363 ? 184.02400 365.07700 26.55900  1.000 49.87163  ? 398 SER F CA  1 
ATOM   2579 C C   . SER A 1 363 ? 183.36100 366.32500 27.12800  1.000 52.48967  ? 398 SER F C   1 
ATOM   2580 O O   . SER A 1 363 ? 183.18000 366.46700 28.34600  1.000 49.87552  ? 398 SER F O   1 
ATOM   2581 C CB  . SER A 1 363 ? 183.19000 364.56100 25.39700  1.000 45.51969  ? 398 SER F CB  1 
ATOM   2582 O OG  . SER A 1 363 ? 181.85500 364.58600 25.81800  1.000 47.55644  ? 398 SER F OG  1 
ATOM   2583 N N   . LYS A 1 364 ? 183.08800 367.26600 26.23300  1.000 51.47305  ? 399 LYS F N   1 
ATOM   2584 C CA  . LYS A 1 364 ? 182.29300 368.45600 26.51200  1.000 48.32278  ? 399 LYS F CA  1 
ATOM   2585 C C   . LYS A 1 364 ? 181.13200 368.43600 25.52200  1.000 59.69847  ? 399 LYS F C   1 
ATOM   2586 O O   . LYS A 1 364 ? 180.56000 369.48500 25.16800  1.000 57.42700  ? 399 LYS F O   1 
ATOM   2587 C CB  . LYS A 1 364 ? 183.09500 369.76300 26.47400  1.000 42.55081  ? 399 LYS F CB  1 
ATOM   2588 C CG  . LYS A 1 364 ? 184.20300 369.89200 27.54200  1.000 42.56844  ? 399 LYS F CG  1 
ATOM   2589 C CD  . LYS A 1 364 ? 185.11500 371.13000 27.37100  1.000 45.05001  ? 399 LYS F CD  1 
ATOM   2590 C CE  . LYS A 1 364 ? 184.42500 372.49500 27.60200  1.000 53.45208  ? 399 LYS F CE  1 
ATOM   2591 N NZ  . LYS A 1 364 ? 183.96600 372.73200 29.00200  1.000 49.33204  ? 399 LYS F NZ  1 
ATOM   2592 N N   . THR A 1 365 ? 180.72400 367.20900 25.12400  1.000 50.55916  ? 400 THR F N   1 
ATOM   2593 C CA  . THR A 1 365 ? 179.72100 367.06000 24.08400  1.000 48.45815  ? 400 THR F CA  1 
ATOM   2594 C C   . THR A 1 365 ? 178.36600 366.73900 24.71300  1.000 47.87707  ? 400 THR F C   1 
ATOM   2595 O O   . THR A 1 365 ? 177.98700 365.57800 24.92900  1.000 48.72903  ? 400 THR F O   1 
ATOM   2596 C CB  . THR A 1 365 ? 180.20700 365.92800 23.15900  1.000 55.55430  ? 400 THR F CB  1 
ATOM   2597 O OG1 . THR A 1 365 ? 181.52700 366.23100 22.66500  1.000 59.59040  ? 400 THR F OG1 1 
ATOM   2598 C CG2 . THR A 1 365 ? 179.25600 365.67800 21.95100  1.000 54.89679  ? 400 THR F CG2 1 
ATOM   2599 N N   . ASP A 1 366 ? 177.62900 367.81700 25.00400  1.000 45.98411  ? 401 ASP F N   1 
ATOM   2600 C CA  . ASP A 1 366 ? 176.29900 367.73600 25.60800  1.000 51.35798  ? 401 ASP F CA  1 
ATOM   2601 C C   . ASP A 1 366 ? 175.17300 367.88600 24.56100  1.000 56.44559  ? 401 ASP F C   1 
ATOM   2602 O O   . ASP A 1 366 ? 174.67800 368.99400 24.27800  1.000 50.72384  ? 401 ASP F O   1 
ATOM   2603 C CB  . ASP A 1 366 ? 176.16600 368.66100 26.85100  1.000 51.93119  ? 401 ASP F CB  1 
ATOM   2604 C CG  . ASP A 1 366 ? 176.60500 370.10900 26.62900  1.000 65.10010  ? 401 ASP F CG  1 
ATOM   2605 O OD1 . ASP A 1 366 ? 177.44800 370.38200 25.73600  1.000 68.60550  ? 401 ASP F OD1 1 
ATOM   2606 O OD2 . ASP A 1 366 ? 176.16600 370.95500 27.47200  1.000 56.41042  ? 401 ASP F OD2 1 
ATOM   2607 N N   . VAL A 1 367 ? 174.88300 366.79600 23.84900  1.000 44.58972  ? 402 VAL F N   1 
ATOM   2608 C CA  . VAL A 1 367 ? 173.75500 366.74500 22.91200  1.000 34.79968  ? 402 VAL F CA  1 
ATOM   2609 C C   . VAL A 1 367 ? 172.71200 365.82100 23.53400  1.000 29.65669  ? 402 VAL F C   1 
ATOM   2610 O O   . VAL A 1 367 ? 173.04600 364.78000 24.11500  1.000 37.84746  ? 402 VAL F O   1 
ATOM   2611 C CB  . VAL A 1 367 ? 174.11000 366.31800 21.46900  1.000 33.09444  ? 402 VAL F CB  1 
ATOM   2612 C CG1 . VAL A 1 367 ? 172.87300 366.23800 20.64800  1.000 27.67997  ? 402 VAL F CG1 1 
ATOM   2613 C CG2 . VAL A 1 367 ? 174.95100 367.38200 20.81300  1.000 30.30981  ? 402 VAL F CG2 1 
ATOM   2614 N N   . SER A 1 368 ? 171.45900 366.21400 23.46300  1.000 25.52699  ? 403 SER F N   1 
ATOM   2615 C CA  . SER A 1 368 ? 170.46200 365.39400 24.11000  1.000 26.61608  ? 403 SER F CA  1 
ATOM   2616 C C   . SER A 1 368 ? 170.29300 364.08300 23.35100  1.000 26.66123  ? 403 SER F C   1 
ATOM   2617 O O   . SER A 1 368 ? 170.39500 364.02100 22.12300  1.000 26.99412  ? 403 SER F O   1 
ATOM   2618 C CB  . SER A 1 368 ? 169.14300 366.15800 24.18200  1.000 28.15826  ? 403 SER F CB  1 
ATOM   2619 O OG  . SER A 1 368 ? 169.31500 367.30000 25.00300  1.000 33.51249  ? 403 SER F OG  1 
ATOM   2620 N N   . SER A 1 369 ? 169.97000 363.03300 24.09400  1.000 25.57807  ? 404 SER F N   1 
ATOM   2621 C CA  . SER A 1 369 ? 169.77000 361.72600 23.49400  1.000 24.11850  ? 404 SER F CA  1 
ATOM   2622 C C   . SER A 1 369 ? 168.98800 360.87200 24.47400  1.000 23.87957  ? 404 SER F C   1 
ATOM   2623 O O   . SER A 1 369 ? 168.83100 361.21500 25.64700  1.000 23.00173  ? 404 SER F O   1 
ATOM   2624 C CB  . SER A 1 369 ? 171.10100 361.07400 23.13200  1.000 23.54073  ? 404 SER F CB  1 
ATOM   2625 O OG  . SER A 1 369 ? 171.92600 360.90000 24.29000  1.000 28.18744  ? 404 SER F OG  1 
ATOM   2626 N N   . SER A 1 370 ? 168.54500 359.72900 23.98800  1.000 27.69753  ? 405 SER F N   1 
ATOM   2627 C CA  . SER A 1 370 ? 167.84000 358.77500 24.81600  1.000 24.83115  ? 405 SER F CA  1 
ATOM   2628 C C   . SER A 1 370 ? 168.24500 357.34600 24.46300  1.000 20.91840  ? 405 SER F C   1 
ATOM   2629 O O   . SER A 1 370 ? 168.68900 357.04800 23.35300  1.000 29.20997  ? 405 SER F O   1 
ATOM   2630 C CB  . SER A 1 370 ? 166.33500 358.93600 24.66100  1.000 26.25093  ? 405 SER F CB  1 
ATOM   2631 O OG  . SER A 1 370 ? 165.64900 358.00900 25.49700  1.000 29.87049  ? 405 SER F OG  1 
ATOM   2632 N N   . VAL A 1 371 ? 168.12400 356.46900 25.43400  1.000 18.60602  ? 406 VAL F N   1 
ATOM   2633 C CA  . VAL A 1 371 ? 168.40300 355.06000 25.24100  1.000 25.75250  ? 406 VAL F CA  1 
ATOM   2634 C C   . VAL A 1 371 ? 167.17700 354.32000 25.74600  1.000 22.81813  ? 406 VAL F C   1 
ATOM   2635 O O   . VAL A 1 371 ? 166.77600 354.49500 26.90500  1.000 22.01893  ? 406 VAL F O   1 
ATOM   2636 C CB  . VAL A 1 371 ? 169.65000 354.55800 26.01000  1.000 21.07418  ? 406 VAL F CB  1 
ATOM   2637 C CG1 . VAL A 1 371 ? 169.78000 353.11600 25.79300  1.000 17.67358  ? 406 VAL F CG1 1 
ATOM   2638 C CG2 . VAL A 1 371 ? 170.89300 355.17400 25.51600  1.000 17.81957  ? 406 VAL F CG2 1 
ATOM   2639 N N   . ILE A 1 372 ? 166.56200 353.54000 24.86500  1.000 23.27325  ? 407 ILE F N   1 
ATOM   2640 C CA  . ILE A 1 372 ? 165.43700 352.68900 25.23600  1.000 23.46293  ? 407 ILE F CA  1 
ATOM   2641 C C   . ILE A 1 372 ? 166.02400 351.43500 25.85500  1.000 23.37336  ? 407 ILE F C   1 
ATOM   2642 O O   . ILE A 1 372 ? 166.72600 350.67300 25.18300  1.000 21.24004  ? 407 ILE F O   1 
ATOM   2643 C CB  . ILE A 1 372 ? 164.55400 352.32500 24.03900  1.000 25.56490  ? 407 ILE F CB  1 
ATOM   2644 C CG1 . ILE A 1 372 ? 163.89500 353.57400 23.43800  1.000 27.73479  ? 407 ILE F CG1 1 
ATOM   2645 C CG2 . ILE A 1 372 ? 163.53400 351.30700 24.49000  1.000 22.21756  ? 407 ILE F CG2 1 
ATOM   2646 C CD1 . ILE A 1 372 ? 163.03500 354.32200 24.41800  1.000 25.59063  ? 407 ILE F CD1 1 
ATOM   2647 N N   . THR A 1 373 ? 165.72100 351.21000 27.11800  1.000 25.05247  ? 408 THR F N   1 
ATOM   2648 C CA  . THR A 1 373 ? 166.21500 350.07200 27.86400  1.000 20.39085  ? 408 THR F CA  1 
ATOM   2649 C C   . THR A 1 373 ? 165.20500 348.93200 27.74400  1.000 27.95899  ? 408 THR F C   1 
ATOM   2650 O O   . THR A 1 373 ? 164.31600 348.93800 26.88100  1.000 32.97806  ? 408 THR F O   1 
ATOM   2651 C CB  . THR A 1 373 ? 166.39000 350.46400 29.32000  1.000 24.41468  ? 408 THR F CB  1 
ATOM   2652 O OG1 . THR A 1 373 ? 165.08300 350.67400 29.89400  1.000 28.29594  ? 408 THR F OG1 1 
ATOM   2653 C CG2 . THR A 1 373 ? 167.22200 351.71700 29.45200  1.000 17.59343  ? 408 THR F CG2 1 
ATOM   2654 N N   . SER A 1 374 ? 165.37100 347.88900 28.55100  1.000 26.23423  ? 409 SER F N   1 
ATOM   2655 C CA  . SER A 1 374 ? 164.44600 346.77200 28.43600  1.000 31.06393  ? 409 SER F CA  1 
ATOM   2656 C C   . SER A 1 374 ? 163.09600 347.09800 29.05000  1.000 32.84501  ? 409 SER F C   1 
ATOM   2657 O O   . SER A 1 374 ? 162.06500 346.66700 28.52600  1.000 36.36695  ? 409 SER F O   1 
ATOM   2658 C CB  . SER A 1 374 ? 165.03600 345.50300 29.07600  1.000 38.78820  ? 409 SER F CB  1 
ATOM   2659 O OG  . SER A 1 374 ? 166.33500 345.17900 28.56100  1.000 32.70058  ? 409 SER F OG  1 
ATOM   2660 N N   . LEU A 1 375 ? 163.08100 347.90400 30.11700  1.000 33.23136  ? 410 LEU F N   1 
ATOM   2661 C CA  . LEU A 1 375 ? 161.86200 348.23300 30.84800  1.000 31.73177  ? 410 LEU F CA  1 
ATOM   2662 C C   . LEU A 1 375 ? 161.63300 349.73600 31.01800  1.000 34.16611  ? 410 LEU F C   1 
ATOM   2663 O O   . LEU A 1 375 ? 160.83100 350.13100 31.87200  1.000 30.53167  ? 410 LEU F O   1 
ATOM   2664 C CB  . LEU A 1 375 ? 161.93100 347.60100 32.23700  1.000 32.19601  ? 410 LEU F CB  1 
ATOM   2665 C CG  . LEU A 1 375 ? 162.05300 346.09400 32.40500  1.000 30.29044  ? 410 LEU F CG  1 
ATOM   2666 C CD1 . LEU A 1 375 ? 162.20100 345.83600 33.90800  1.000 35.61239  ? 410 LEU F CD1 1 
ATOM   2667 C CD2 . LEU A 1 375 ? 160.91200 345.33300 31.82500  1.000 29.62498  ? 410 LEU F CD2 1 
ATOM   2668 N N   . GLY A 1 376 ? 162.31100 350.59400 30.25000  1.000 33.62132  ? 411 GLY F N   1 
ATOM   2669 C CA  . GLY A 1 376 ? 162.11600 352.02400 30.43400  1.000 25.26961  ? 411 GLY F CA  1 
ATOM   2670 C C   . GLY A 1 376 ? 162.97100 352.84400 29.50000  1.000 24.78087  ? 411 GLY F C   1 
ATOM   2671 O O   . GLY A 1 376 ? 163.17800 352.43300 28.35900  1.000 27.83407  ? 411 GLY F O   1 
ATOM   2672 N N   . ALA A 1 377 ? 163.46300 354.00400 29.93900  1.000 24.74695  ? 412 ALA F N   1 
ATOM   2673 C CA  . ALA A 1 377 ? 164.25200 354.84000 29.04300  1.000 22.86499  ? 412 ALA F CA  1 
ATOM   2674 C C   . ALA A 1 377 ? 165.14600 355.78500 29.82700  1.000 23.86752  ? 412 ALA F C   1 
ATOM   2675 O O   . ALA A 1 377 ? 164.70600 356.39500 30.79800  1.000 26.05524  ? 412 ALA F O   1 
ATOM   2676 C CB  . ALA A 1 377 ? 163.35400 355.65900 28.12300  1.000 20.49051  ? 412 ALA F CB  1 
ATOM   2677 N N   . ILE A 1 378 ? 166.38100 355.85500 29.45500  1.000 22.33120  ? 413 ILE F N   1 
ATOM   2678 C CA  . ILE A 1 378 ? 167.26000 356.87700 29.99000  1.000 20.95032  ? 413 ILE F CA  1 
ATOM   2679 C C   . ILE A 1 378 ? 167.16600 358.07800 29.07800  1.000 22.51679  ? 413 ILE F C   1 
ATOM   2680 O O   . ILE A 1 378 ? 167.03100 357.92600 27.85400  1.000 22.11128  ? 413 ILE F O   1 
ATOM   2681 C CB  . ILE A 1 378 ? 168.71300 356.39300 30.09200  1.000 21.68697  ? 413 ILE F CB  1 
ATOM   2682 C CG1 . ILE A 1 378 ? 168.80500 355.06000 30.83200  1.000 22.67025  ? 413 ILE F CG1 1 
ATOM   2683 C CG2 . ILE A 1 378 ? 169.58100 357.45200 30.70600  1.000 20.35998  ? 413 ILE F CG2 1 
ATOM   2684 C CD1 . ILE A 1 378 ? 170.24000 354.52100 30.85000  1.000 20.18566  ? 413 ILE F CD1 1 
ATOM   2685 N N   . VAL A 1 379 ? 167.10400 359.27000 29.66200  1.000 22.32847  ? 414 VAL F N   1 
ATOM   2686 C CA  . VAL A 1 379 ? 167.02600 360.48200 28.86400  1.000 20.41162  ? 414 VAL F CA  1 
ATOM   2687 C C   . VAL A 1 379 ? 168.12800 361.39600 29.34300  1.000 21.62565  ? 414 VAL F C   1 
ATOM   2688 O O   . VAL A 1 379 ? 168.19900 361.72100 30.53400  1.000 21.22195  ? 414 VAL F O   1 
ATOM   2689 C CB  . VAL A 1 379 ? 165.67200 361.19400 28.90600  1.000 22.03226  ? 414 VAL F CB  1 
ATOM   2690 C CG1 . VAL A 1 379 ? 165.82200 362.50500 28.15100  1.000 19.48906  ? 414 VAL F CG1 1 
ATOM   2691 C CG2 . VAL A 1 379 ? 164.60800 360.34700 28.16800  1.000 21.18374  ? 414 VAL F CG2 1 
ATOM   2692 N N   . SER A 1 380 ? 169.01300 361.76600 28.42900  1.000 20.40931  ? 415 SER F N   1 
ATOM   2693 C CA  . SER A 1 380 ? 170.03200 362.75400 28.70000  1.000 23.16304  ? 415 SER F CA  1 
ATOM   2694 C C   . SER A 1 380 ? 169.60800 364.00100 27.96700  1.000 26.97032  ? 415 SER F C   1 
ATOM   2695 O O   . SER A 1 380 ? 169.71400 364.07800 26.73400  1.000 24.93150  ? 415 SER F O   1 
ATOM   2696 C CB  . SER A 1 380 ? 171.42400 362.31900 28.25800  1.000 24.81531  ? 415 SER F CB  1 
ATOM   2697 O OG  . SER A 1 380 ? 171.86600 361.17900 28.94700  1.000 24.73166  ? 415 SER F OG  1 
ATOM   2698 N N   . CYS A 1 381 ? 169.12600 364.96600 28.74100  1.000 24.34808  ? 416 CYS F N   1 
ATOM   2699 C CA  . CYS A 1 381 ? 168.58700 366.20600 28.22100  1.000 25.58505  ? 416 CYS F CA  1 
ATOM   2700 C C   . CYS A 1 381 ? 169.54700 367.32200 28.59500  1.000 27.45406  ? 416 CYS F C   1 
ATOM   2701 O O   . CYS A 1 381 ? 169.82000 367.54900 29.77900  1.000 25.46202  ? 416 CYS F O   1 
ATOM   2702 C CB  . CYS A 1 381 ? 167.20400 366.47400 28.80600  1.000 27.59991  ? 416 CYS F CB  1 
ATOM   2703 S SG  . CYS A 1 381 ? 166.12600 367.50200 27.80000  1.000 36.79880  ? 416 CYS F SG  1 
ATOM   2704 N N   . TYR A 1 382 ? 169.97900 368.07200 27.59400  1.000 25.46196  ? 417 TYR F N   1 
ATOM   2705 C CA  . TYR A 1 382 ? 170.92000 369.15800 27.78000  1.000 27.03558  ? 417 TYR F CA  1 
ATOM   2706 C C   . TYR A 1 382 ? 170.53500 370.28800 26.84800  1.000 28.63059  ? 417 TYR F C   1 
ATOM   2707 O O   . TYR A 1 382 ? 169.82500 370.06900 25.85700  1.000 28.45030  ? 417 TYR F O   1 
ATOM   2708 C CB  . TYR A 1 382 ? 172.40100 368.70900 27.58200  1.000 28.90594  ? 417 TYR F CB  1 
ATOM   2709 C CG  . TYR A 1 382 ? 172.77300 367.52800 28.46100  1.000 31.05026  ? 417 TYR F CG  1 
ATOM   2710 C CD1 . TYR A 1 382 ? 172.92500 367.71900 29.82700  1.000 25.65661  ? 417 TYR F CD1 1 
ATOM   2711 C CD2 . TYR A 1 382 ? 172.91500 366.24000 27.95600  1.000 32.12763  ? 417 TYR F CD2 1 
ATOM   2712 C CE1 . TYR A 1 382 ? 173.20900 366.68300 30.67200  1.000 29.40880  ? 417 TYR F CE1 1 
ATOM   2713 C CE2 . TYR A 1 382 ? 173.20500 365.17300 28.80100  1.000 26.10617  ? 417 TYR F CE2 1 
ATOM   2714 C CZ  . TYR A 1 382 ? 173.35500 365.42100 30.17000  1.000 31.57560  ? 417 TYR F CZ  1 
ATOM   2715 O OH  . TYR A 1 382 ? 173.65500 364.43600 31.08500  1.000 35.02776  ? 417 TYR F OH  1 
ATOM   2716 N N   . GLY A 1 383 ? 170.87400 371.51200 27.27600  1.000 22.17911  ? 418 GLY F N   1 
ATOM   2717 C CA  . GLY A 1 383 ? 170.61200 372.69000 26.48300  1.000 19.99925  ? 418 GLY F CA  1 
ATOM   2718 C C   . GLY A 1 383 ? 169.15100 373.08100 26.52200  1.000 24.48095  ? 418 GLY F C   1 
ATOM   2719 O O   . GLY A 1 383 ? 168.51100 373.02100 27.57800  1.000 29.53011  ? 418 GLY F O   1 
ATOM   2720 N N   . LYS A 1 384 ? 168.64200 373.50000 25.35700  1.000 20.53320  ? 419 LYS F N   1 
ATOM   2721 C CA  . LYS A 1 384 ? 167.26900 373.92000 25.09800  1.000 22.43366  ? 419 LYS F CA  1 
ATOM   2722 C C   . LYS A 1 384 ? 166.39600 372.78900 24.57000  1.000 26.18689  ? 419 LYS F C   1 
ATOM   2723 O O   . LYS A 1 384 ? 165.34300 373.04800 23.96600  1.000 30.50162  ? 419 LYS F O   1 
ATOM   2724 C CB  . LYS A 1 384 ? 167.23800 375.12900 24.13000  1.000 20.84347  ? 419 LYS F CB  1 
ATOM   2725 C CG  . LYS A 1 384 ? 168.27800 376.17000 24.44000  1.000 17.76033  ? 419 LYS F CG  1 
ATOM   2726 C CD  . LYS A 1 384 ? 168.26500 377.36100 23.52000  1.000 12.43666  ? 419 LYS F CD  1 
ATOM   2727 C CE  . LYS A 1 384 ? 167.87900 378.64300 24.26700  1.000 30.11498  ? 419 LYS F CE  1 
ATOM   2728 N NZ  . LYS A 1 384 ? 168.79200 378.94800 25.39800  1.000 26.96298  ? 419 LYS F NZ  1 
ATOM   2729 N N   . THR A 1 385 ? 166.85200 371.55500 24.66700  1.000 27.99866  ? 420 THR F N   1 
ATOM   2730 C CA  . THR A 1 385 ? 166.10500 370.46000 24.06900  1.000 29.30394  ? 420 THR F CA  1 
ATOM   2731 C C   . THR A 1 385 ? 164.81600 370.21200 24.85900  1.000 31.01754  ? 420 THR F C   1 
ATOM   2732 O O   . THR A 1 385 ? 164.78400 370.31600 26.09700  1.000 27.09742  ? 420 THR F O   1 
ATOM   2733 C CB  . THR A 1 385 ? 166.94600 369.19400 24.04400  1.000 29.51977  ? 420 THR F CB  1 
ATOM   2734 O OG1 . THR A 1 385 ? 168.23700 369.51000 23.52800  1.000 39.51462  ? 420 THR F OG1 1 
ATOM   2735 C CG2 . THR A 1 385 ? 166.33500 368.21000 23.05200  1.000 30.75839  ? 420 THR F CG2 1 
ATOM   2736 N N   . LYS A 1 386 ? 163.73400 369.93000 24.13000  1.000 32.38952  ? 421 LYS F N   1 
ATOM   2737 C CA  . LYS A 1 386 ? 162.41800 369.65300 24.71800  1.000 29.13342  ? 421 LYS F CA  1 
ATOM   2738 C C   . LYS A 1 386 ? 162.29000 368.13000 24.88400  1.000 27.04336  ? 421 LYS F C   1 
ATOM   2739 O O   . LYS A 1 386 ? 162.22300 367.39700 23.89100  1.000 31.44119  ? 421 LYS F O   1 
ATOM   2740 C CB  . LYS A 1 386 ? 161.31600 370.22500 23.83000  1.000 24.42243  ? 421 LYS F CB  1 
ATOM   2741 C CG  . LYS A 1 386 ? 159.89000 369.95100 24.31000  1.000 30.25288  ? 421 LYS F CG  1 
ATOM   2742 C CD  . LYS A 1 386 ? 158.85100 370.54900 23.31100  1.000 42.61176  ? 421 LYS F CD  1 
ATOM   2743 C CE  . LYS A 1 386 ? 157.37400 370.29300 23.74800  1.000 41.64269  ? 421 LYS F CE  1 
ATOM   2744 N NZ  . LYS A 1 386 ? 156.88000 368.91500 23.41000  1.000 47.55330  ? 421 LYS F NZ  1 
ATOM   2745 N N   . CYS A 1 387 ? 162.52600 367.63100 26.09500  1.000 22.31736  ? 422 CYS F N   1 
ATOM   2746 C CA  . CYS A 1 387 ? 162.41700 366.20500 26.42300  1.000 26.78903  ? 422 CYS F CA  1 
ATOM   2747 C C   . CYS A 1 387 ? 161.16700 365.87300 27.23300  1.000 23.59377  ? 422 CYS F C   1 
ATOM   2748 O O   . CYS A 1 387 ? 160.92200 366.49800 28.26400  1.000 29.12936  ? 422 CYS F O   1 
ATOM   2749 C CB  . CYS A 1 387 ? 163.66300 365.71400 27.16800  1.000 26.35312  ? 422 CYS F CB  1 
ATOM   2750 S SG  . CYS A 1 387 ? 165.19700 366.26800 26.38600  1.000 26.51185  ? 422 CYS F SG  1 
ATOM   2751 N N   . THR A 1 388 ? 160.46400 364.79900 26.86700  1.000 20.00242  ? 423 THR F N   1 
ATOM   2752 C CA  . THR A 1 388 ? 159.19300 364.44700 27.50300  1.000 22.98412  ? 423 THR F CA  1 
ATOM   2753 C C   . THR A 1 388 ? 158.90500 362.94900 27.38200  1.000 26.43526  ? 423 THR F C   1 
ATOM   2754 O O   . THR A 1 388 ? 159.50600 362.22400 26.57400  1.000 28.32367  ? 423 THR F O   1 
ATOM   2755 C CB  . THR A 1 388 ? 157.98000 365.14500 26.87700  1.000 24.86808  ? 423 THR F CB  1 
ATOM   2756 O OG1 . THR A 1 388 ? 157.71400 364.50200 25.61300  1.000 25.62366  ? 423 THR F OG1 1 
ATOM   2757 C CG2 . THR A 1 388 ? 158.16300 366.65800 26.73500  1.000 17.73021  ? 423 THR F CG2 1 
ATOM   2758 N N   . ALA A 1 389 ? 157.94000 362.50000 28.18700  1.000 21.67334  ? 424 ALA F N   1 
ATOM   2759 C CA  . ALA A 1 389 ? 157.44400 361.13100 28.16100  1.000 21.96787  ? 424 ALA F CA  1 
ATOM   2760 C C   . ALA A 1 389 ? 155.91800 361.14200 28.13200  1.000 25.54604  ? 424 ALA F C   1 
ATOM   2761 O O   . ALA A 1 389 ? 155.27300 361.80300 28.95600  1.000 25.43553  ? 424 ALA F O   1 
ATOM   2762 C CB  . ALA A 1 389 ? 157.96000 360.34000 29.36400  1.000 25.28895  ? 424 ALA F CB  1 
ATOM   2763 N N   . SER A 1 390 ? 155.34100 360.48000 27.14300  1.000 27.67339  ? 425 SER F N   1 
ATOM   2764 C CA  . SER A 1 390 ? 153.90600 360.52700 26.92800  1.000 28.55509  ? 425 SER F CA  1 
ATOM   2765 C C   . SER A 1 390 ? 153.25400 359.15200 26.98700  1.000 33.45374  ? 425 SER F C   1 
ATOM   2766 O O   . SER A 1 390 ? 153.90700 358.10400 26.86400  1.000 30.22662  ? 425 SER F O   1 
ATOM   2767 C CB  . SER A 1 390 ? 153.58400 361.16300 25.59000  1.000 24.38877  ? 425 SER F CB  1 
ATOM   2768 O OG  . SER A 1 390 ? 154.20000 362.42700 25.55700  1.000 31.04607  ? 425 SER F OG  1 
ATOM   2769 N N   . ASN A 1 391 ? 151.96200 359.20700 27.30300  1.000 35.32384  ? 426 ASN F N   1 
ATOM   2770 C CA  . ASN A 1 391 ? 151.01200 358.11000 27.22900  1.000 34.81658  ? 426 ASN F CA  1 
ATOM   2771 C C   . ASN A 1 391 ? 150.11100 358.37700 26.03500  1.000 38.27542  ? 426 ASN F C   1 
ATOM   2772 O O   . ASN A 1 391 ? 149.76800 359.53100 25.75900  1.000 36.14405  ? 426 ASN F O   1 
ATOM   2773 C CB  . ASN A 1 391 ? 150.17100 358.03100 28.49200  1.000 36.55113  ? 426 ASN F CB  1 
ATOM   2774 C CG  . ASN A 1 391 ? 149.20900 356.88200 28.46100  1.000 46.81877  ? 426 ASN F CG  1 
ATOM   2775 O OD1 . ASN A 1 391 ? 148.08700 357.03200 27.94800  1.000 47.61949  ? 426 ASN F OD1 1 
ATOM   2776 N ND2 . ASN A 1 391 ? 149.60500 355.73900 29.01500  1.000 47.41423  ? 426 ASN F ND2 1 
ATOM   2777 N N   . LYS A 1 392 ? 149.70200 357.31400 25.33900  1.000 41.35545  ? 427 LYS F N   1 
ATOM   2778 C CA  . LYS A 1 392 ? 148.99200 357.51900 24.07700  1.000 43.22811  ? 427 LYS F CA  1 
ATOM   2779 C C   . LYS A 1 392 ? 147.69000 358.29500 24.26700  1.000 43.46371  ? 427 LYS F C   1 
ATOM   2780 O O   . LYS A 1 392 ? 147.34600 359.11500 23.41400  1.000 50.62626  ? 427 LYS F O   1 
ATOM   2781 C CB  . LYS A 1 392 ? 148.78000 356.19900 23.34100  1.000 45.11199  ? 427 LYS F CB  1 
ATOM   2782 C CG  . LYS A 1 392 ? 148.35300 356.40200 21.86900  1.000 50.38204  ? 427 LYS F CG  1 
ATOM   2783 C CD  . LYS A 1 392 ? 147.88600 355.09200 21.19400  1.000 57.24410  ? 427 LYS F CD  1 
ATOM   2784 C CE  . LYS A 1 392 ? 146.43300 355.08600 20.72100  1.000 58.85104  ? 427 LYS F CE  1 
ATOM   2785 N NZ  . LYS A 1 392 ? 145.43200 354.92100 21.84600  1.000 62.33594  ? 427 LYS F NZ  1 
ATOM   2786 N N   . ASN A 1 393 ? 146.98500 358.11400 25.39100  1.000 44.21684  ? 428 ASN F N   1 
ATOM   2787 C CA  . ASN A 1 393 ? 145.69500 358.77700 25.58000  1.000 46.65969  ? 428 ASN F CA  1 
ATOM   2788 C C   . ASN A 1 393 ? 145.75600 359.95400 26.53200  1.000 49.37593  ? 428 ASN F C   1 
ATOM   2789 O O   . ASN A 1 393 ? 144.88100 360.82200 26.47300  1.000 59.55799  ? 428 ASN F O   1 
ATOM   2790 C CB  . ASN A 1 393 ? 144.64600 357.83500 26.19900  1.000 50.43144  ? 428 ASN F CB  1 
ATOM   2791 C CG  . ASN A 1 393 ? 144.52000 356.52900 25.47700  1.000 58.18527  ? 428 ASN F CG  1 
ATOM   2792 O OD1 . ASN A 1 393 ? 143.83200 356.43100 24.45200  1.000 55.31675  ? 428 ASN F OD1 1 
ATOM   2793 N ND2 . ASN A 1 393 ? 145.13300 355.49000 26.04100  1.000 60.75259  ? 428 ASN F ND2 1 
ATOM   2794 N N   . ARG A 1 394 ? 146.75200 360.01200 27.39200  1.000 45.44403  ? 429 ARG F N   1 
ATOM   2795 C CA  . ARG A 1 394 ? 146.86500 361.13800 28.28400  1.000 39.95341  ? 429 ARG F CA  1 
ATOM   2796 C C   . ARG A 1 394 ? 147.77500 362.22900 27.76300  1.000 39.24351  ? 429 ARG F C   1 
ATOM   2797 O O   . ARG A 1 394 ? 147.68500 363.36000 28.26100  1.000 47.85030  ? 429 ARG F O   1 
ATOM   2798 C CB  . ARG A 1 394 ? 147.29300 360.66200 29.66300  1.000 49.76162  ? 429 ARG F CB  1 
ATOM   2799 C CG  . ARG A 1 394 ? 146.46300 359.48300 30.13100  1.000 47.35319  ? 429 ARG F CG  1 
ATOM   2800 C CD  . ARG A 1 394 ? 146.55200 359.38500 31.63000  1.000 59.70955  ? 429 ARG F CD  1 
ATOM   2801 N NE  . ARG A 1 394 ? 147.21200 358.15800 32.04600  1.000 67.58586  ? 429 ARG F NE  1 
ATOM   2802 C CZ  . ARG A 1 394 ? 146.61800 356.97500 32.08900  1.000 70.01859  ? 429 ARG F CZ  1 
ATOM   2803 N NH1 . ARG A 1 394 ? 145.31000 356.85300 31.89500  1.000 75.02171  ? 429 ARG F NH1 1 
ATOM   2804 N NH2 . ARG A 1 394 ? 147.34700 355.89500 32.36600  1.000 66.59648  ? 429 ARG F NH2 1 
ATOM   2805 N N   . GLY A 1 395 ? 148.70600 361.91600 26.85600  1.000 37.64651  ? 430 GLY F N   1 
ATOM   2806 C CA  . GLY A 1 395 ? 149.60900 362.95700 26.39000  1.000 28.96088  ? 430 GLY F CA  1 
ATOM   2807 C C   . GLY A 1 395 ? 150.88700 362.99900 27.19300  1.000 33.05665  ? 430 GLY F C   1 
ATOM   2808 O O   . GLY A 1 395 ? 151.33600 361.97900 27.70900  1.000 37.70199  ? 430 GLY F O   1 
ATOM   2809 N N   . ILE A 1 396 ? 151.49500 364.17300 27.28600  1.000 29.22409  ? 431 ILE F N   1 
ATOM   2810 C CA  . ILE A 1 396 ? 152.74600 364.32300 28.01200  1.000 26.98306  ? 431 ILE F CA  1 
ATOM   2811 C C   . ILE A 1 396 ? 152.49300 364.12300 29.50600  1.000 28.75659  ? 431 ILE F C   1 
ATOM   2812 O O   . ILE A 1 396 ? 151.66800 364.80700 30.11200  1.000 37.57080  ? 431 ILE F O   1 
ATOM   2813 C CB  . ILE A 1 396 ? 153.34700 365.71000 27.74100  1.000 23.12381  ? 431 ILE F CB  1 
ATOM   2814 C CG1 . ILE A 1 396 ? 153.81200 365.79700 26.28800  1.000 24.79200  ? 431 ILE F CG1 1 
ATOM   2815 C CG2 . ILE A 1 396 ? 154.47400 365.98900 28.69400  1.000 21.11847  ? 431 ILE F CG2 1 
ATOM   2816 C CD1 . ILE A 1 396 ? 154.32000 367.17000 25.88100  1.000 18.86419  ? 431 ILE F CD1 1 
ATOM   2817 N N   . ILE A 1 397 ? 153.12200 363.11500 30.09200  1.000 28.06257  ? 432 ILE F N   1 
ATOM   2818 C CA  . ILE A 1 397 ? 152.98500 362.86400 31.51900  1.000 25.61348  ? 432 ILE F CA  1 
ATOM   2819 C C   . ILE A 1 397 ? 154.24800 363.19500 32.30400  1.000 26.18676  ? 432 ILE F C   1 
ATOM   2820 O O   . ILE A 1 397 ? 154.19600 363.23800 33.54600  1.000 26.23495  ? 432 ILE F O   1 
ATOM   2821 C CB  . ILE A 1 397 ? 152.54900 361.42800 31.82700  1.000 27.68145  ? 432 ILE F CB  1 
ATOM   2822 C CG1 . ILE A 1 397 ? 153.53000 360.44400 31.25700  1.000 26.89515  ? 432 ILE F CG1 1 
ATOM   2823 C CG2 . ILE A 1 397 ? 151.16200 361.20700 31.19300  1.000 25.82683  ? 432 ILE F CG2 1 
ATOM   2824 C CD1 . ILE A 1 397 ? 153.15800 359.06500 31.64900  1.000 33.88681  ? 432 ILE F CD1 1 
ATOM   2825 N N   . LYS A 1 398 ? 155.38200 363.42100 31.64300  1.000 24.23597  ? 433 LYS F N   1 
ATOM   2826 C CA  . LYS A 1 398 ? 156.57800 363.79700 32.38600  1.000 24.48245  ? 433 LYS F CA  1 
ATOM   2827 C C   . LYS A 1 398 ? 157.45500 364.61300 31.46500  1.000 24.08924  ? 433 LYS F C   1 
ATOM   2828 O O   . LYS A 1 398 ? 157.51200 364.31600 30.27000  1.000 25.47337  ? 433 LYS F O   1 
ATOM   2829 C CB  . LYS A 1 398 ? 157.36400 362.57000 32.89000  1.000 19.97394  ? 433 LYS F CB  1 
ATOM   2830 C CG  . LYS A 1 398 ? 158.62000 362.90600 33.68500  1.000 21.72090  ? 433 LYS F CG  1 
ATOM   2831 C CD  . LYS A 1 398 ? 159.14800 361.63900 34.37100  1.000 34.82390  ? 433 LYS F CD  1 
ATOM   2832 C CE  . LYS A 1 398 ? 160.28500 361.85700 35.35900  1.000 30.90845  ? 433 LYS F CE  1 
ATOM   2833 N NZ  . LYS A 1 398 ? 161.27000 362.85500 34.96000  1.000 35.86335  ? 433 LYS F NZ  1 
ATOM   2834 N N   . THR A 1 399 ? 157.94700 365.74200 31.98300  1.000 24.31430  ? 434 THR F N   1 
ATOM   2835 C CA  . THR A 1 399 ? 158.90300 366.60500 31.30300  1.000 26.30270  ? 434 THR F CA  1 
ATOM   2836 C C   . THR A 1 399 ? 160.25000 366.54100 31.99300  1.000 26.71203  ? 434 THR F C   1 
ATOM   2837 O O   . THR A 1 399 ? 160.36300 366.87700 33.17100  1.000 31.44073  ? 434 THR F O   1 
ATOM   2838 C CB  . THR A 1 399 ? 158.40100 368.03700 31.29200  1.000 25.30840  ? 434 THR F CB  1 
ATOM   2839 O OG1 . THR A 1 399 ? 157.10700 368.04300 30.69200  1.000 29.31356  ? 434 THR F OG1 1 
ATOM   2840 C CG2 . THR A 1 399 ? 159.32000 368.90300 30.50600  1.000 28.46807  ? 434 THR F CG2 1 
ATOM   2841 N N   . PHE A 1 400 ? 161.27800 366.13100 31.25400  1.000 31.27351  ? 435 PHE F N   1 
ATOM   2842 C CA  . PHE A 1 400 ? 162.58500 365.99800 31.86900  1.000 31.04627  ? 435 PHE F CA  1 
ATOM   2843 C C   . PHE A 1 400 ? 163.24400 367.36000 31.94900  1.000 33.39742  ? 435 PHE F C   1 
ATOM   2844 O O   . PHE A 1 400 ? 163.12600 368.17800 31.02900  1.000 33.15849  ? 435 PHE F O   1 
ATOM   2845 C CB  . PHE A 1 400 ? 163.48700 365.03600 31.08700  1.000 25.86578  ? 435 PHE F CB  1 
ATOM   2846 C CG  . PHE A 1 400 ? 162.91000 363.67400 30.93400  1.000 24.17531  ? 435 PHE F CG  1 
ATOM   2847 C CD1 . PHE A 1 400 ? 163.05300 362.73400 31.93500  1.000 28.44924  ? 435 PHE F CD1 1 
ATOM   2848 C CD2 . PHE A 1 400 ? 162.26200 363.31800 29.77400  1.000 21.49920  ? 435 PHE F CD2 1 
ATOM   2849 C CE1 . PHE A 1 400 ? 162.52600 361.46900 31.79400  1.000 28.30092  ? 435 PHE F CE1 1 
ATOM   2850 C CE2 . PHE A 1 400 ? 161.71500 362.05600 29.63100  1.000 23.59871  ? 435 PHE F CE2 1 
ATOM   2851 C CZ  . PHE A 1 400 ? 161.85800 361.12400 30.63800  1.000 25.77496  ? 435 PHE F CZ  1 
ATOM   2852 N N   . SER A 1 401 ? 163.90800 367.62200 33.06800  1.000 35.64198  ? 436 SER F N   1 
ATOM   2853 C CA  . SER A 1 401 ? 164.69200 368.83000 33.10600  1.000 36.99338  ? 436 SER F CA  1 
ATOM   2854 C C   . SER A 1 401 ? 166.11600 368.43700 32.69800  1.000 36.78372  ? 436 SER F C   1 
ATOM   2855 O O   . SER A 1 401 ? 166.43600 367.26100 32.51600  1.000 35.96975  ? 436 SER F O   1 
ATOM   2856 C CB  . SER A 1 401 ? 164.53600 369.54000 34.45300  1.000 33.56361  ? 436 SER F CB  1 
ATOM   2857 O OG  . SER A 1 401 ? 164.87000 368.72800 35.54300  1.000 36.08664  ? 436 SER F OG  1 
ATOM   2858 N N   . ASN A 1 402 ? 167.00500 369.40700 32.70300  1.000 35.51930  ? 437 ASN F N   1 
ATOM   2859 C CA  . ASN A 1 402 ? 168.38000 369.18300 32.29200  1.000 32.20128  ? 437 ASN F CA  1 
ATOM   2860 C C   . ASN A 1 402 ? 169.12200 368.28600 33.26300  1.000 34.78976  ? 437 ASN F C   1 
ATOM   2861 O O   . ASN A 1 402 ? 169.00700 368.43000 34.47900  1.000 38.94104  ? 437 ASN F O   1 
ATOM   2862 C CB  . ASN A 1 402 ? 169.08300 370.51800 32.08200  1.000 28.67989  ? 437 ASN F CB  1 
ATOM   2863 C CG  . ASN A 1 402 ? 168.86100 371.04900 30.67300  1.000 30.74769  ? 437 ASN F CG  1 
ATOM   2864 O OD1 . ASN A 1 402 ? 168.01000 370.54100 29.92400  1.000 32.01769  ? 437 ASN F OD1 1 
ATOM   2865 N ND2 . ASN A 1 402 ? 169.60400 372.07900 30.30500  1.000 41.02376  ? 437 ASN F ND2 1 
ATOM   2866 N N   . GLY A 1 403 ? 169.79200 367.28800 32.71100  1.000 34.55068  ? 438 GLY F N   1 
ATOM   2867 C CA  . GLY A 1 403 ? 170.52600 366.25900 33.39900  1.000 30.57314  ? 438 GLY F CA  1 
ATOM   2868 C C   . GLY A 1 403 ? 170.14900 364.92600 32.83600  1.000 31.86979  ? 438 GLY F C   1 
ATOM   2869 O O   . GLY A 1 403 ? 169.60100 364.82900 31.72900  1.000 33.89385  ? 438 GLY F O   1 
ATOM   2870 N N   . CYS A 1 404 ? 170.52000 363.86000 33.54900  1.000 29.73450  ? 439 CYS F N   1 
ATOM   2871 C CA  . CYS A 1 404 ? 170.20500 362.51500 33.09900  1.000 27.91416  ? 439 CYS F CA  1 
ATOM   2872 C C   . CYS A 1 404 ? 169.12100 361.95300 34.00200  1.000 25.06643  ? 439 CYS F C   1 
ATOM   2873 O O   . CYS A 1 404 ? 169.28800 361.92700 35.22200  1.000 30.74340  ? 439 CYS F O   1 
ATOM   2874 C CB  . CYS A 1 404 ? 171.46200 361.63500 33.12000  1.000 29.27944  ? 439 CYS F CB  1 
ATOM   2875 S SG  . CYS A 1 404 ? 171.12400 359.85400 32.71200  1.000 44.02964  ? 439 CYS F SG  1 
ATOM   2876 N N   . ASP A 1 405 ? 168.06000 361.41900 33.39800  1.000 25.42044  ? 440 ASP F N   1 
ATOM   2877 C CA  . ASP A 1 405 ? 166.93000 360.88800 34.14700  1.000 25.56164  ? 440 ASP F CA  1 
ATOM   2878 C C   . ASP A 1 405 ? 166.43200 359.59700 33.48700  1.000 23.73833  ? 440 ASP F C   1 
ATOM   2879 O O   . ASP A 1 405 ? 166.90000 359.19000 32.42100  1.000 21.94901  ? 440 ASP F O   1 
ATOM   2880 C CB  . ASP A 1 405 ? 165.81400 361.94100 34.20400  1.000 25.72998  ? 440 ASP F CB  1 
ATOM   2881 C CG  . ASP A 1 405 ? 164.95100 361.84100 35.43600  1.000 31.93747  ? 440 ASP F CG  1 
ATOM   2882 O OD1 . ASP A 1 405 ? 164.94100 360.79000 36.13800  1.000 32.88886  ? 440 ASP F OD1 1 
ATOM   2883 O OD2 . ASP A 1 405 ? 164.22300 362.83200 35.66800  1.000 39.97150  ? 440 ASP F OD2 1 
ATOM   2884 N N   . TYR A 1 406 ? 165.37500 359.02800 34.05600  1.000 24.70340  ? 441 TYR F N   1 
ATOM   2885 C CA  . TYR A 1 406 ? 164.85900 357.74300 33.62400  1.000 23.78609  ? 441 TYR F CA  1 
ATOM   2886 C C   . TYR A 1 406 ? 163.36900 357.64700 33.88600  1.000 22.63290  ? 441 TYR F C   1 
ATOM   2887 O O   . TYR A 1 406 ? 162.86100 358.28600 34.81000  1.000 30.80576  ? 441 TYR F O   1 
ATOM   2888 C CB  . TYR A 1 406 ? 165.57800 356.65300 34.43200  1.000 24.43763  ? 441 TYR F CB  1 
ATOM   2889 C CG  . TYR A 1 406 ? 165.05300 355.24400 34.27200  1.000 27.88183  ? 441 TYR F CG  1 
ATOM   2890 C CD1 . TYR A 1 406 ? 165.50200 354.41600 33.23400  1.000 25.23682  ? 441 TYR F CD1 1 
ATOM   2891 C CD2 . TYR A 1 406 ? 164.08300 354.74400 35.14200  1.000 24.09375  ? 441 TYR F CD2 1 
ATOM   2892 C CE1 . TYR A 1 406 ? 165.02700 353.11700 33.08800  1.000 23.71142  ? 441 TYR F CE1 1 
ATOM   2893 C CE2 . TYR A 1 406 ? 163.59700 353.43900 34.99900  1.000 29.36104  ? 441 TYR F CE2 1 
ATOM   2894 C CZ  . TYR A 1 406 ? 164.07700 352.63900 33.96300  1.000 29.64290  ? 441 TYR F CZ  1 
ATOM   2895 O OH  . TYR A 1 406 ? 163.61400 351.35600 33.79900  1.000 33.84844  ? 441 TYR F OH  1 
ATOM   2896 N N   . VAL A 1 407 ? 162.66100 356.88200 33.06500  1.000 15.44683  ? 442 VAL F N   1 
ATOM   2897 C CA  . VAL A 1 407 ? 161.23900 356.67700 33.28400  1.000 23.69348  ? 442 VAL F CA  1 
ATOM   2898 C C   . VAL A 1 407 ? 160.95300 355.21400 32.97100  1.000 29.15159  ? 442 VAL F C   1 
ATOM   2899 O O   . VAL A 1 407 ? 161.50000 354.67700 32.00200  1.000 32.84622  ? 442 VAL F O   1 
ATOM   2900 C CB  . VAL A 1 407 ? 160.38000 357.64200 32.44000  1.000 27.51042  ? 442 VAL F CB  1 
ATOM   2901 C CG1 . VAL A 1 407 ? 160.55900 357.35800 30.95600  1.000 27.59779  ? 442 VAL F CG1 1 
ATOM   2902 C CG2 . VAL A 1 407 ? 158.92400 357.56700 32.85700  1.000 26.58468  ? 442 VAL F CG2 1 
ATOM   2903 N N   . SER A 1 408 ? 160.08300 354.57400 33.76500  1.000 29.39457  ? 443 SER F N   1 
ATOM   2904 C CA  . SER A 1 408 ? 159.69400 353.17000 33.56900  1.000 30.88915  ? 443 SER F CA  1 
ATOM   2905 C C   . SER A 1 408 ? 158.65400 353.07300 32.45500  1.000 32.22151  ? 443 SER F C   1 
ATOM   2906 O O   . SER A 1 408 ? 158.11000 354.07300 32.00000  1.000 32.15897  ? 443 SER F O   1 
ATOM   2907 C CB  . SER A 1 408 ? 159.16500 352.48100 34.81900  1.000 27.41221  ? 443 SER F CB  1 
ATOM   2908 O OG  . SER A 1 408 ? 157.96900 353.05900 35.24500  1.000 43.20904  ? 443 SER F OG  1 
ATOM   2909 N N   . ASN A 1 409 ? 158.42700 351.85600 31.96400  1.000 34.11769  ? 444 ASN F N   1 
ATOM   2910 C CA  . ASN A 1 409 ? 157.43200 351.62900 30.92100  1.000 34.19622  ? 444 ASN F CA  1 
ATOM   2911 C C   . ASN A 1 409 ? 156.02600 351.56300 31.48400  1.000 36.41586  ? 444 ASN F C   1 
ATOM   2912 O O   . ASN A 1 409 ? 155.05300 351.46600 30.71200  1.000 34.15967  ? 444 ASN F O   1 
ATOM   2913 C CB  . ASN A 1 409 ? 157.71600 350.34600 30.13000  1.000 32.18758  ? 444 ASN F CB  1 
ATOM   2914 C CG  . ASN A 1 409 ? 157.74400 349.09600 30.99000  1.000 37.41164  ? 444 ASN F CG  1 
ATOM   2915 O OD1 . ASN A 1 409 ? 157.59000 349.14400 32.21500  1.000 40.47809  ? 444 ASN F OD1 1 
ATOM   2916 N ND2 . ASN A 1 409 ? 157.96800 347.95200 30.34200  1.000 39.27002  ? 444 ASN F ND2 1 
ATOM   2917 N N   . LYS A 1 410 ? 155.91200 351.59700 32.80900  1.000 37.13222  ? 445 LYS F N   1 
ATOM   2918 C CA  . LYS A 1 410 ? 154.59600 351.54200 33.45300  1.000 40.87027  ? 445 LYS F CA  1 
ATOM   2919 C C   . LYS A 1 410 ? 153.87400 352.87700 33.25700  1.000 40.55437  ? 445 LYS F C   1 
ATOM   2920 O O   . LYS A 1 410 ? 154.23300 353.89900 33.85100  1.000 37.14165  ? 445 LYS F O   1 
ATOM   2921 C CB  . LYS A 1 410 ? 154.76100 351.15000 34.92600  1.000 34.59702  ? 445 LYS F CB  1 
ATOM   2922 C CG  . LYS A 1 410 ? 155.24700 349.69700 35.04700  1.000 44.34439  ? 445 LYS F CG  1 
ATOM   2923 C CD  . LYS A 1 410 ? 155.43900 349.21100 36.49300  1.000 55.78096  ? 445 LYS F CD  1 
ATOM   2924 C CE  . LYS A 1 410 ? 155.75900 347.70100 36.54300  1.000 50.02822  ? 445 LYS F CE  1 
ATOM   2925 N NZ  . LYS A 1 410 ? 155.58800 347.11800 35.13200  1.000 48.54760  ? 445 LYS F NZ  1 
ATOM   2926 N N   . GLY A 1 411 ? 152.93700 352.90600 32.28900  1.000 35.32274  ? 446 GLY F N   1 
ATOM   2927 C CA  . GLY A 1 411 ? 152.16500 354.10200 31.99400  1.000 33.33510  ? 446 GLY F CA  1 
ATOM   2928 C C   . GLY A 1 411 ? 152.74500 354.97000 30.88900  1.000 39.02202  ? 446 GLY F C   1 
ATOM   2929 O O   . GLY A 1 411 ? 152.14000 355.99100 30.54700  1.000 46.64509  ? 446 GLY F O   1 
ATOM   2930 N N   . VAL A 1 412 ? 153.95800 354.66900 30.41600  1.000 39.90683  ? 447 VAL F N   1 
ATOM   2931 C CA  . VAL A 1 412 ? 154.65800 355.40900 29.36600  1.000 32.08362  ? 447 VAL F CA  1 
ATOM   2932 C C   . VAL A 1 412 ? 154.66500 354.57200 28.09200  1.000 32.83120  ? 447 VAL F C   1 
ATOM   2933 O O   . VAL A 1 412 ? 154.92900 353.36100 28.14400  1.000 32.95448  ? 447 VAL F O   1 
ATOM   2934 C CB  . VAL A 1 412 ? 156.08600 355.77700 29.80000  1.000 34.76101  ? 447 VAL F CB  1 
ATOM   2935 C CG1 . VAL A 1 412 ? 156.83800 356.45500 28.65800  1.000 33.43916  ? 447 VAL F CG1 1 
ATOM   2936 C CG2 . VAL A 1 412 ? 156.02000 356.73600 30.98700  1.000 27.00981  ? 447 VAL F CG2 1 
ATOM   2937 N N   . ASP A 1 413 ? 154.34800 355.20300 26.96000  1.000 31.37779  ? 448 ASP F N   1 
ATOM   2938 C CA  . ASP A 1 413 ? 154.36300 354.56900 25.63800  1.000 29.50887  ? 448 ASP F CA  1 
ATOM   2939 C C   . ASP A 1 413 ? 155.50400 355.06300 24.75900  1.000 30.42356  ? 448 ASP F C   1 
ATOM   2940 O O   . ASP A 1 413 ? 156.14600 354.27400 24.05600  1.000 31.57302  ? 448 ASP F O   1 
ATOM   2941 C CB  . ASP A 1 413 ? 153.00700 354.75200 24.95600  1.000 26.22864  ? 448 ASP F CB  1 
ATOM   2942 C CG  . ASP A 1 413 ? 151.90100 354.00200 25.71000  1.000 39.25343  ? 448 ASP F CG  1 
ATOM   2943 O OD1 . ASP A 1 413 ? 152.23900 352.93500 26.29000  1.000 35.89333  ? 448 ASP F OD1 1 
ATOM   2944 O OD2 . ASP A 1 413 ? 150.73700 354.48700 25.78200  1.000 39.93770  ? 448 ASP F OD2 1 
ATOM   2945 N N   . THR A 1 414 ? 155.71400 356.37000 24.71800  1.000 29.69460  ? 449 THR F N   1 
ATOM   2946 C CA  . THR A 1 414 ? 156.74000 357.00300 23.91600  1.000 25.40217  ? 449 THR F CA  1 
ATOM   2947 C C   . THR A 1 414 ? 157.49700 358.01100 24.77700  1.000 26.05560  ? 449 THR F C   1 
ATOM   2948 O O   . THR A 1 414 ? 157.06600 358.37600 25.87300  1.000 27.44360  ? 449 THR F O   1 
ATOM   2949 C CB  . THR A 1 414 ? 156.15200 357.67000 22.68100  1.000 26.45864  ? 449 THR F CB  1 
ATOM   2950 O OG1 . THR A 1 414 ? 155.20700 358.67900 23.08000  1.000 32.34497  ? 449 THR F OG1 1 
ATOM   2951 C CG2 . THR A 1 414 ? 155.46200 356.62100 21.84300  1.000 23.47295  ? 449 THR F CG2 1 
ATOM   2952 N N   . VAL A 1 415 ? 158.69100 358.35300 24.30800  1.000 25.44181  ? 450 VAL F N   1 
ATOM   2953 C CA  . VAL A 1 415 ? 159.58600 359.35300 24.88000  1.000 22.95669  ? 450 VAL F CA  1 
ATOM   2954 C C   . VAL A 1 415 ? 160.08500 360.24500 23.73900  1.000 25.68494  ? 450 VAL F C   1 
ATOM   2955 O O   . VAL A 1 415 ? 160.35400 359.73700 22.64400  1.000 29.42792  ? 450 VAL F O   1 
ATOM   2956 C CB  . VAL A 1 415 ? 160.75600 358.67900 25.62500  1.000 25.72255  ? 450 VAL F CB  1 
ATOM   2957 C CG1 . VAL A 1 415 ? 161.84700 359.65400 25.91900  1.000 27.44693  ? 450 VAL F CG1 1 
ATOM   2958 C CG2 . VAL A 1 415 ? 160.27200 358.04300 26.89400  1.000 22.73267  ? 450 VAL F CG2 1 
ATOM   2959 N N   . SER A 1 416 ? 159.97200 361.55800 23.88300  1.000 21.33127  ? 451 SER F N   1 
ATOM   2960 C CA  . SER A 1 416 ? 160.41200 362.47900 22.83000  1.000 21.58170  ? 451 SER F CA  1 
ATOM   2961 C C   . SER A 1 416 ? 161.63000 363.29000 23.27300  1.000 25.71606  ? 451 SER F C   1 
ATOM   2962 O O   . SER A 1 416 ? 161.64700 363.85000 24.37500  1.000 27.91205  ? 451 SER F O   1 
ATOM   2963 C CB  . SER A 1 416 ? 159.30400 363.41600 22.37800  1.000 20.53183  ? 451 SER F CB  1 
ATOM   2964 O OG  . SER A 1 416 ? 158.27400 362.66700 21.76300  1.000 30.63394  ? 451 SER F OG  1 
ATOM   2965 N N   . VAL A 1 417 ? 162.66000 363.32500 22.43100  1.000 26.74255  ? 452 VAL F N   1 
ATOM   2966 C CA  . VAL A 1 417 ? 163.85600 364.11900 22.66900  1.000 24.37376  ? 452 VAL F CA  1 
ATOM   2967 C C   . VAL A 1 417 ? 164.07900 364.96600 21.42600  1.000 28.40141  ? 452 VAL F C   1 
ATOM   2968 O O   . VAL A 1 417 ? 164.39100 364.42700 20.35500  1.000 30.67183  ? 452 VAL F O   1 
ATOM   2969 C CB  . VAL A 1 417 ? 165.08400 363.24700 22.94200  1.000 25.34857  ? 452 VAL F CB  1 
ATOM   2970 C CG1 . VAL A 1 417 ? 166.32800 364.10900 23.00000  1.000 21.86525  ? 452 VAL F CG1 1 
ATOM   2971 C CG2 . VAL A 1 417 ? 164.89600 362.44200 24.22200  1.000 27.09416  ? 452 VAL F CG2 1 
ATOM   2972 N N   . GLY A 1 418 ? 163.83600 366.27200 21.53800  1.000 27.18159  ? 453 GLY F N   1 
ATOM   2973 C CA  . GLY A 1 418 ? 163.93700 367.11400 20.35800  1.000 25.70763  ? 453 GLY F CA  1 
ATOM   2974 C C   . GLY A 1 418 ? 162.86500 366.72600 19.35100  1.000 25.76997  ? 453 GLY F C   1 
ATOM   2975 O O   . GLY A 1 418 ? 161.71600 366.47000 19.70900  1.000 26.81072  ? 453 GLY F O   1 
ATOM   2976 N N   . ASN A 1 419 ? 163.29000 366.49900 18.10500  1.000 28.16937  ? 454 ASN F N   1 
ATOM   2977 C CA  . ASN A 1 419 ? 162.41600 366.08500 17.01700  1.000 26.52577  ? 454 ASN F CA  1 
ATOM   2978 C C   . ASN A 1 419 ? 162.36800 364.57700 16.78800  1.000 28.60531  ? 454 ASN F C   1 
ATOM   2979 O O   . ASN A 1 419 ? 161.88300 364.13400 15.74600  1.000 33.23414  ? 454 ASN F O   1 
ATOM   2980 C CB  . ASN A 1 419 ? 162.85700 366.78500 15.74600  1.000 25.25565  ? 454 ASN F CB  1 
ATOM   2981 C CG  . ASN A 1 419 ? 162.77500 368.26200 15.88700  1.000 31.09388  ? 454 ASN F CG  1 
ATOM   2982 O OD1 . ASN A 1 419 ? 161.95500 368.75200 16.67300  1.000 34.04388  ? 454 ASN F OD1 1 
ATOM   2983 N ND2 . ASN A 1 419 ? 163.61900 369.00300 15.15100  1.000 27.75911  ? 454 ASN F ND2 1 
ATOM   2984 N N   . THR A 1 420 ? 162.81600 363.78300 17.74400  1.000 27.40142  ? 455 THR F N   1 
ATOM   2985 C CA  . THR A 1 420 ? 162.84700 362.33400 17.61900  1.000 33.59308  ? 455 THR F CA  1 
ATOM   2986 C C   . THR A 1 420 ? 161.88700 361.66700 18.60400  1.000 30.48429  ? 455 THR F C   1 
ATOM   2987 O O   . THR A 1 420 ? 161.86900 362.02000 19.78500  1.000 26.01053  ? 455 THR F O   1 
ATOM   2988 C CB  . THR A 1 420 ? 164.25900 361.79000 17.86400  1.000 37.46120  ? 455 THR F CB  1 
ATOM   2989 O OG1 . THR A 1 420 ? 165.18400 362.38500 16.94200  1.000 44.68782  ? 455 THR F OG1 1 
ATOM   2990 C CG2 . THR A 1 420 ? 164.28000 360.26300 17.73900  1.000 33.01771  ? 455 THR F CG2 1 
ATOM   2991 N N   . LEU A 1 421 ? 161.10700 360.69600 18.13800  1.000 29.52522  ? 456 LEU F N   1 
ATOM   2992 C CA  . LEU A 1 421 ? 160.19300 359.97900 19.01500  1.000 30.30410  ? 456 LEU F CA  1 
ATOM   2993 C C   . LEU A 1 421 ? 160.62100 358.51400 19.06300  1.000 31.54186  ? 456 LEU F C   1 
ATOM   2994 O O   . LEU A 1 421 ? 160.66000 357.83100 18.02500  1.000 32.39964  ? 456 LEU F O   1 
ATOM   2995 C CB  . LEU A 1 421 ? 158.76100 360.09500 18.50100  1.000 22.06064  ? 456 LEU F CB  1 
ATOM   2996 C CG  . LEU A 1 421 ? 157.74800 359.42200 19.41100  1.000 27.84094  ? 456 LEU F CG  1 
ATOM   2997 C CD1 . LEU A 1 421 ? 156.55200 360.24600 19.57600  1.000 36.16103  ? 456 LEU F CD1 1 
ATOM   2998 C CD2 . LEU A 1 421 ? 157.32400 358.09300 18.85300  1.000 30.96277  ? 456 LEU F CD2 1 
ATOM   2999 N N   . TYR A 1 422 ? 160.93400 358.03700 20.27600  1.000 32.64337  ? 457 TYR F N   1 
ATOM   3000 C CA  . TYR A 1 422 ? 161.29500 356.64800 20.51000  1.000 31.74799  ? 457 TYR F CA  1 
ATOM   3001 C C   . TYR A 1 422 ? 160.11100 355.93600 21.14500  1.000 32.81139  ? 457 TYR F C   1 
ATOM   3002 O O   . TYR A 1 422 ? 159.43100 356.49300 22.01400  1.000 31.91444  ? 457 TYR F O   1 
ATOM   3003 C CB  . TYR A 1 422 ? 162.50200 356.52800 21.43300  1.000 27.00164  ? 457 TYR F CB  1 
ATOM   3004 C CG  . TYR A 1 422 ? 163.74800 357.33000 21.07800  1.000 38.85835  ? 457 TYR F CG  1 
ATOM   3005 C CD1 . TYR A 1 422 ? 163.88400 358.66800 21.51500  1.000 40.62313  ? 457 TYR F CD1 1 
ATOM   3006 C CD2 . TYR A 1 422 ? 164.77900 356.78800 20.30000  1.000 42.64124  ? 457 TYR F CD2 1 
ATOM   3007 C CE1 . TYR A 1 422 ? 165.04500 359.43000 21.21500  1.000 44.36575  ? 457 TYR F CE1 1 
ATOM   3008 C CE2 . TYR A 1 422 ? 165.94500 357.53400 19.99000  1.000 47.55990  ? 457 TYR F CE2 1 
ATOM   3009 C CZ  . TYR A 1 422 ? 166.08000 358.85700 20.45200  1.000 56.68785  ? 457 TYR F CZ  1 
ATOM   3010 O OH  . TYR A 1 422 ? 167.24000 359.60400 20.15900  1.000 54.00431  ? 457 TYR F OH  1 
ATOM   3011 N N   . CYS A 1 423 ? 160.05800 354.63500 20.92300  1.000 36.36477  ? 458 CYS F N   1 
ATOM   3012 C CA  . CYS A 1 423 ? 159.02600 353.78000 21.47900  1.000 32.76475  ? 458 CYS F CA  1 
ATOM   3013 C C   . CYS A 1 423 ? 159.55700 352.96500 22.65200  1.000 33.94662  ? 458 CYS F C   1 
ATOM   3014 O O   . CYS A 1 423 ? 160.66100 352.41100 22.59800  1.000 37.50433  ? 458 CYS F O   1 
ATOM   3015 C CB  . CYS A 1 423 ? 158.53000 352.85500 20.37200  1.000 48.66036  ? 458 CYS F CB  1 
ATOM   3016 S SG  . CYS A 1 423 ? 157.58300 353.77800 19.11200  1.000 61.47515  ? 458 CYS F SG  1 
ATOM   3017 N N   . VAL A 1 424 ? 158.77600 352.90700 23.71900  1.000 33.49086  ? 459 VAL F N   1 
ATOM   3018 C CA  . VAL A 1 424 ? 159.17000 352.20000 24.93000  1.000 27.55530  ? 459 VAL F CA  1 
ATOM   3019 C C   . VAL A 1 424 ? 158.72300 350.74800 24.85700  1.000 33.82808  ? 459 VAL F C   1 
ATOM   3020 O O   . VAL A 1 424 ? 157.57400 350.45900 24.50900  1.000 41.40395  ? 459 VAL F O   1 
ATOM   3021 C CB  . VAL A 1 424 ? 158.58100 352.90800 26.15500  1.000 26.92522  ? 459 VAL F CB  1 
ATOM   3022 C CG1 . VAL A 1 424 ? 159.05100 352.24900 27.40700  1.000 31.69948  ? 459 VAL F CG1 1 
ATOM   3023 C CG2 . VAL A 1 424 ? 159.07400 354.32300 26.14300  1.000 30.67908  ? 459 VAL F CG2 1 
ATOM   3024 N N   . ASN A 1 425 ? 159.61100 349.82800 25.23200  1.000 31.83168  ? 460 ASN F N   1 
ATOM   3025 C CA  . ASN A 1 425 ? 159.24700 348.41800 25.22600  1.000 35.66905  ? 460 ASN F CA  1 
ATOM   3026 C C   . ASN A 1 425 ? 158.20000 348.15100 26.29500  1.000 35.91525  ? 460 ASN F C   1 
ATOM   3027 O O   . ASN A 1 425 ? 158.37400 348.54800 27.45100  1.000 36.52943  ? 460 ASN F O   1 
ATOM   3028 C CB  . ASN A 1 425 ? 160.50500 347.57800 25.48900  1.000 36.52175  ? 460 ASN F CB  1 
ATOM   3029 C CG  . ASN A 1 425 ? 160.25200 346.07800 25.44000  1.000 46.26995  ? 460 ASN F CG  1 
ATOM   3030 O OD1 . ASN A 1 425 ? 159.10800 345.61600 25.57100  1.000 48.56452  ? 460 ASN F OD1 1 
ATOM   3031 N ND2 . ASN A 1 425 ? 161.33000 345.29900 25.23200  1.000 43.64177  ? 460 ASN F ND2 1 
ATOM   3032 N N   . LYS A 1 426 ? 157.09400 347.49800 25.90600  1.000 40.29307  ? 461 LYS F N   1 
ATOM   3033 C CA  . LYS A 1 426 ? 155.98200 347.22500 26.82100  1.000 41.93079  ? 461 LYS F CA  1 
ATOM   3034 C C   . LYS A 1 426 ? 156.11700 345.88100 27.52200  1.000 41.17403  ? 461 LYS F C   1 
ATOM   3035 O O   . LYS A 1 426 ? 155.11600 345.32300 27.98100  1.000 50.13359  ? 461 LYS F O   1 
ATOM   3036 C CB  . LYS A 1 426 ? 154.63900 347.31600 26.09700  1.000 38.90514  ? 461 LYS F CB  1 
ATOM   3037 C CG  . LYS A 1 426 ? 154.38700 348.61900 25.36800  1.000 38.32507  ? 461 LYS F CG  1 
ATOM   3038 C CD  . LYS A 1 426 ? 154.51600 349.86700 26.25800  1.000 42.76156  ? 461 LYS F CD  1 
ATOM   3039 C CE  . LYS A 1 426 ? 153.45000 349.90100 27.36000  1.000 42.61707  ? 461 LYS F CE  1 
ATOM   3040 N NZ  . LYS A 1 426 ? 153.58300 351.10100 28.27300  1.000 41.61600  ? 461 LYS F NZ  1 
ATOM   3041 N N   . GLN A 1 427 ? 157.34300 345.42700 27.72900  1.000 40.24609  ? 462 GLN F N   1 
ATOM   3042 C CA  . GLN A 1 427 ? 157.63500 344.17200 28.40200  1.000 41.33715  ? 462 GLN F CA  1 
ATOM   3043 C C   . GLN A 1 427 ? 157.35200 344.28800 29.88600  1.000 47.92736  ? 462 GLN F C   1 
ATOM   3044 O O   . GLN A 1 427 ? 157.55400 345.34700 30.49300  1.000 44.76147  ? 462 GLN F O   1 
ATOM   3045 C CB  . GLN A 1 427 ? 159.12300 343.81000 28.21200  1.000 47.75018  ? 462 GLN F CB  1 
ATOM   3046 C CG  . GLN A 1 427 ? 159.60900 342.53700 28.93500  1.000 51.41293  ? 462 GLN F CG  1 
ATOM   3047 C CD  . GLN A 1 427 ? 160.45500 341.61700 28.09300  1.000 62.51674  ? 462 GLN F CD  1 
ATOM   3048 O OE1 . GLN A 1 427 ? 160.19400 340.40600 28.01200  1.000 62.28062  ? 462 GLN F OE1 1 
ATOM   3049 N NE2 . GLN A 1 427 ? 161.45400 342.19100 27.41700  1.000 61.19738  ? 462 GLN F NE2 1 
ATOM   3050 N N   . GLU A 1 428 ? 156.81700 343.21600 30.45900  1.000 46.86906  ? 463 GLU F N   1 
ATOM   3051 C CA  . GLU A 1 428 ? 156.52400 343.22700 31.88300  1.000 50.53830  ? 463 GLU F CA  1 
ATOM   3052 C C   . GLU A 1 428 ? 157.79300 343.00000 32.70700  1.000 39.63118  ? 463 GLU F C   1 
ATOM   3053 O O   . GLU A 1 428 ? 158.64500 342.17500 32.36500  1.000 42.50195  ? 463 GLU F O   1 
ATOM   3054 C CB  . GLU A 1 428 ? 155.47700 342.16200 32.23100  1.000 57.03601  ? 463 GLU F CB  1 
ATOM   3055 C CG  . GLU A 1 428 ? 154.04200 342.68800 32.20100  1.000 65.48439  ? 463 GLU F CG  1 
ATOM   3056 C CD  . GLU A 1 428 ? 153.67400 343.46100 33.47500  1.000 75.41441  ? 463 GLU F CD  1 
ATOM   3057 O OE1 . GLU A 1 428 ? 154.48400 343.46200 34.44000  1.000 65.37576  ? 463 GLU F OE1 1 
ATOM   3058 O OE2 . GLU A 1 428 ? 152.58100 344.08400 33.50200  1.000 82.76361  ? 463 GLU F OE2 1 
ATOM   3059 N N   . GLY A 1 429 ? 157.92800 343.77500 33.77300  1.000 36.41369  ? 464 GLY F N   1 
ATOM   3060 C CA  . GLY A 1 429 ? 159.06700 343.68900 34.66600  1.000 33.46095  ? 464 GLY F CA  1 
ATOM   3061 C C   . GLY A 1 429 ? 159.00200 344.81700 35.67000  1.000 35.82900  ? 464 GLY F C   1 
ATOM   3062 O O   . GLY A 1 429 ? 158.15100 345.69600 35.59700  1.000 43.44769  ? 464 GLY F O   1 
ATOM   3063 N N   . GLN A 1 430 ? 159.91100 344.77500 36.63100  1.000 38.82457  ? 465 GLN F N   1 
ATOM   3064 C CA  . GLN A 1 430 ? 159.95900 345.77200 37.69200  1.000 42.91237  ? 465 GLN F CA  1 
ATOM   3065 C C   . GLN A 1 430 ? 161.17200 346.68200 37.48800  1.000 42.56441  ? 465 GLN F C   1 
ATOM   3066 O O   . GLN A 1 430 ? 162.29900 346.19400 37.35800  1.000 39.27635  ? 465 GLN F O   1 
ATOM   3067 C CB  . GLN A 1 430 ? 160.00600 345.08000 39.06300  1.000 45.09942  ? 465 GLN F CB  1 
ATOM   3068 C CG  . GLN A 1 430 ? 159.83000 346.00300 40.27700  1.000 57.28227  ? 465 GLN F CG  1 
ATOM   3069 C CD  . GLN A 1 430 ? 158.56000 346.86400 40.19700  1.000 68.22025  ? 465 GLN F CD  1 
ATOM   3070 O OE1 . GLN A 1 430 ? 158.62100 348.11000 40.23700  1.000 68.64642  ? 465 GLN F OE1 1 
ATOM   3071 N NE2 . GLN A 1 430 ? 157.40600 346.20200 40.05600  1.000 67.45510  ? 465 GLN F NE2 1 
ATOM   3072 N N   . SER A 1 431 ? 160.95600 347.99600 37.49400  1.000 39.17241  ? 466 SER F N   1 
ATOM   3073 C CA  . SER A 1 431 ? 162.05600 348.93900 37.40500  1.000 31.52629  ? 466 SER F CA  1 
ATOM   3074 C C   . SER A 1 431 ? 162.30900 349.50100 38.78400  1.000 34.39712  ? 466 SER F C   1 
ATOM   3075 O O   . SER A 1 431 ? 161.38700 349.63900 39.59000  1.000 41.24228  ? 466 SER F O   1 
ATOM   3076 C CB  . SER A 1 431 ? 161.77700 350.09000 36.44300  1.000 33.40404  ? 466 SER F CB  1 
ATOM   3077 O OG  . SER A 1 431 ? 161.56200 349.62800 35.12700  1.000 39.16817  ? 466 SER F OG  1 
ATOM   3078 N N   . LEU A 1 432 ? 163.57300 349.80300 39.05200  1.000 32.13465  ? 467 LEU F N   1 
ATOM   3079 C CA  . LEU A 1 432 ? 164.01200 350.35400 40.32000  1.000 29.69117  ? 467 LEU F CA  1 
ATOM   3080 C C   . LEU A 1 432 ? 164.86600 351.57600 40.01600  1.000 33.53799  ? 467 LEU F C   1 
ATOM   3081 O O   . LEU A 1 432 ? 165.90100 351.45900 39.35600  1.000 34.56207  ? 467 LEU F O   1 
ATOM   3082 C CB  . LEU A 1 432 ? 164.83300 349.32900 41.11200  1.000 30.93876  ? 467 LEU F CB  1 
ATOM   3083 C CG  . LEU A 1 432 ? 165.34100 349.76800 42.50400  1.000 37.40742  ? 467 LEU F CG  1 
ATOM   3084 C CD1 . LEU A 1 432 ? 164.16500 350.17700 43.40200  1.000 29.02068  ? 467 LEU F CD1 1 
ATOM   3085 C CD2 . LEU A 1 432 ? 166.25300 348.74500 43.21300  1.000 34.99368  ? 467 LEU F CD2 1 
ATOM   3086 N N   . TYR A 1 433 ? 164.45100 352.73500 40.50700  1.000 33.83505  ? 468 TYR F N   1 
ATOM   3087 C CA  . TYR A 1 433 ? 165.18500 353.97900 40.30600  1.000 31.34210  ? 468 TYR F CA  1 
ATOM   3088 C C   . TYR A 1 433 ? 166.11100 354.12900 41.51100  1.000 34.83476  ? 468 TYR F C   1 
ATOM   3089 O O   . TYR A 1 433 ? 165.64700 354.41600 42.61800  1.000 34.47593  ? 468 TYR F O   1 
ATOM   3090 C CB  . TYR A 1 433 ? 164.24300 355.16900 40.22700  1.000 24.09678  ? 468 TYR F CB  1 
ATOM   3091 C CG  . TYR A 1 433 ? 164.83000 356.42500 39.64200  1.000 27.56542  ? 468 TYR F CG  1 
ATOM   3092 C CD1 . TYR A 1 433 ? 165.73900 357.17800 40.38700  1.000 30.79451  ? 468 TYR F CD1 1 
ATOM   3093 C CD2 . TYR A 1 433 ? 164.35200 356.96800 38.44700  1.000 24.51347  ? 468 TYR F CD2 1 
ATOM   3094 C CE1 . TYR A 1 433 ? 166.26500 358.36900 39.89600  1.000 27.26441  ? 468 TYR F CE1 1 
ATOM   3095 C CE2 . TYR A 1 433 ? 164.85400 358.17200 37.95300  1.000 23.44068  ? 468 TYR F CE2 1 
ATOM   3096 C CZ  . TYR A 1 433 ? 165.80900 358.87000 38.68900  1.000 26.87991  ? 468 TYR F CZ  1 
ATOM   3097 O OH  . TYR A 1 433 ? 166.34300 360.05500 38.21500  1.000 27.78136  ? 468 TYR F OH  1 
ATOM   3098 N N   . VAL A 1 434 ? 167.41500 353.95400 41.29900  1.000 27.68908  ? 469 VAL F N   1 
ATOM   3099 C CA  . VAL A 1 434 ? 168.39900 354.04400 42.37500  1.000 29.08354  ? 469 VAL F CA  1 
ATOM   3100 C C   . VAL A 1 434 ? 168.92600 355.47500 42.45800  1.000 31.64927  ? 469 VAL F C   1 
ATOM   3101 O O   . VAL A 1 434 ? 169.84200 355.86800 41.73400  1.000 31.57828  ? 469 VAL F O   1 
ATOM   3102 C CB  . VAL A 1 434 ? 169.53000 353.03400 42.19000  1.000 28.52072  ? 469 VAL F CB  1 
ATOM   3103 C CG1 . VAL A 1 434 ? 170.50200 353.19400 43.29300  1.000 20.58288  ? 469 VAL F CG1 1 
ATOM   3104 C CG2 . VAL A 1 434 ? 168.97600 351.59300 42.15000  1.000 23.83857  ? 469 VAL F CG2 1 
ATOM   3105 N N   . LYS A 1 435 ? 168.39000 356.24000 43.40300  1.000 39.22271  ? 470 LYS F N   1 
ATOM   3106 C CA  . LYS A 1 435 ? 168.77800 357.63400 43.54800  1.000 34.07307  ? 470 LYS F CA  1 
ATOM   3107 C C   . LYS A 1 435 ? 170.21700 357.75500 44.03200  1.000 34.83305  ? 470 LYS F C   1 
ATOM   3108 O O   . LYS A 1 435 ? 170.73800 356.88600 44.73700  1.000 34.94722  ? 470 LYS F O   1 
ATOM   3109 C CB  . LYS A 1 435 ? 167.87500 358.34700 44.56300  1.000 31.28770  ? 470 LYS F CB  1 
ATOM   3110 C CG  . LYS A 1 435 ? 166.37900 358.18000 44.35000  1.000 40.57875  ? 470 LYS F CG  1 
ATOM   3111 C CD  . LYS A 1 435 ? 165.72100 359.53900 44.10600  1.000 50.12192  ? 470 LYS F CD  1 
ATOM   3112 C CE  . LYS A 1 435 ? 166.54200 360.38000 43.07900  1.000 49.75529  ? 470 LYS F CE  1 
ATOM   3113 N NZ  . LYS A 1 435 ? 165.82600 361.57800 42.44900  1.000 56.01924  ? 470 LYS F NZ  1 
ATOM   3114 N N   . GLY A 1 436 ? 170.86800 358.83500 43.60400  1.000 34.20030  ? 471 GLY F N   1 
ATOM   3115 C CA  . GLY A 1 436 ? 172.23300 359.12600 43.98100  1.000 28.10590  ? 471 GLY F CA  1 
ATOM   3116 C C   . GLY A 1 436 ? 172.71300 360.39100 43.30400  1.000 31.15642  ? 471 GLY F C   1 
ATOM   3117 O O   . GLY A 1 436 ? 172.13200 360.80000 42.29800  1.000 38.83227  ? 471 GLY F O   1 
ATOM   3118 N N   . GLU A 1 437 ? 173.66800 361.08300 43.90000  1.000 31.23996  ? 472 GLU F N   1 
ATOM   3119 C CA  . GLU A 1 437 ? 174.21900 362.30700 43.30300  1.000 38.75842  ? 472 GLU F CA  1 
ATOM   3120 C C   . GLU A 1 437 ? 175.00700 361.98700 42.03100  1.000 36.15960  ? 472 GLU F C   1 
ATOM   3121 O O   . GLU A 1 437 ? 175.94000 361.17700 42.08700  1.000 37.24860  ? 472 GLU F O   1 
ATOM   3122 C CB  . GLU A 1 437 ? 175.12600 363.03200 44.30900  1.000 40.10793  ? 472 GLU F CB  1 
ATOM   3123 C CG  . GLU A 1 437 ? 175.82400 364.25700 43.72100  1.000 43.57926  ? 472 GLU F CG  1 
ATOM   3124 C CD  . GLU A 1 437 ? 175.03500 365.55200 43.77100  1.000 53.14960  ? 472 GLU F CD  1 
ATOM   3125 O OE1 . GLU A 1 437 ? 173.78100 365.52600 43.64400  1.000 58.85512  ? 472 GLU F OE1 1 
ATOM   3126 O OE2 . GLU A 1 437 ? 175.70100 366.61200 43.86400  1.000 61.18887  ? 472 GLU F OE2 1 
ATOM   3127 N N   . PRO A 1 438 ? 174.75800 362.66900 40.90900  1.000 38.39731  ? 473 PRO F N   1 
ATOM   3128 C CA  . PRO A 1 438 ? 175.57300 362.40500 39.69700  1.000 39.50660  ? 473 PRO F CA  1 
ATOM   3129 C C   . PRO A 1 438 ? 177.05400 362.66400 39.94900  1.000 35.58779  ? 473 PRO F C   1 
ATOM   3130 O O   . PRO A 1 438 ? 177.45100 363.74900 40.38000  1.000 35.96345  ? 473 PRO F O   1 
ATOM   3131 C CB  . PRO A 1 438 ? 175.00500 363.38700 38.65800  1.000 29.93470  ? 473 PRO F CB  1 
ATOM   3132 C CG  . PRO A 1 438 ? 173.61100 363.66700 39.14600  1.000 34.22118  ? 473 PRO F CG  1 
ATOM   3133 C CD  . PRO A 1 438 ? 173.68500 363.64400 40.65400  1.000 35.69306  ? 473 PRO F CD  1 
ATOM   3134 N N   . ILE A 1 439 ? 177.87800 361.65500 39.63700  1.000 33.45248  ? 474 ILE F N   1 
ATOM   3135 C CA  . ILE A 1 439 ? 179.30400 361.71800 39.95700  1.000 35.89869  ? 474 ILE F CA  1 
ATOM   3136 C C   . ILE A 1 439 ? 180.02700 362.80600 39.17700  1.000 34.17722  ? 474 ILE F C   1 
ATOM   3137 O O   . ILE A 1 439 ? 181.13000 363.20800 39.56300  1.000 34.43726  ? 474 ILE F O   1 
ATOM   3138 C CB  . ILE A 1 439 ? 180.02000 360.37200 39.69500  1.000 34.94067  ? 474 ILE F CB  1 
ATOM   3139 C CG1 . ILE A 1 439 ? 180.11800 360.08800 38.19600  1.000 31.74478  ? 474 ILE F CG1 1 
ATOM   3140 C CG2 . ILE A 1 439 ? 179.22100 359.22500 40.31300  1.000 23.99598  ? 474 ILE F CG2 1 
ATOM   3141 C CD1 . ILE A 1 439 ? 180.87100 358.81700 37.87600  1.000 25.72979  ? 474 ILE F CD1 1 
ATOM   3142 N N   . ILE A 1 440 ? 179.40900 363.35200 38.13000  1.000 31.63320  ? 475 ILE F N   1 
ATOM   3143 C CA  . ILE A 1 440 ? 180.07000 364.41700 37.40000  1.000 28.54107  ? 475 ILE F CA  1 
ATOM   3144 C C   . ILE A 1 440 ? 180.18700 365.64800 38.27300  1.000 32.85764  ? 475 ILE F C   1 
ATOM   3145 O O   . ILE A 1 440 ? 181.02300 366.50800 37.99400  1.000 38.43385  ? 475 ILE F O   1 
ATOM   3146 C CB  . ILE A 1 440 ? 179.31100 364.73600 36.08900  1.000 31.04312  ? 475 ILE F CB  1 
ATOM   3147 C CG1 . ILE A 1 440 ? 180.15100 365.61700 35.15500  1.000 30.56067  ? 475 ILE F CG1 1 
ATOM   3148 C CG2 . ILE A 1 440 ? 177.89800 365.34500 36.35600  1.000 31.58721  ? 475 ILE F CG2 1 
ATOM   3149 C CD1 . ILE A 1 440 ? 181.42900 364.98400 34.70600  1.000 30.97822  ? 475 ILE F CD1 1 
ATOM   3150 N N   . ASN A 1 441 ? 179.35300 365.77300 39.31400  1.000 35.60381  ? 476 ASN F N   1 
ATOM   3151 C CA  . ASN A 1 441 ? 179.43100 366.91600 40.22000  1.000 39.08438  ? 476 ASN F CA  1 
ATOM   3152 C C   . ASN A 1 441 ? 180.58800 366.86100 41.22200  1.000 40.63575  ? 476 ASN F C   1 
ATOM   3153 O O   . ASN A 1 441 ? 180.83800 367.86600 41.88400  1.000 42.75244  ? 476 ASN F O   1 
ATOM   3154 C CB  . ASN A 1 441 ? 178.12400 367.08900 41.00400  1.000 37.32314  ? 476 ASN F CB  1 
ATOM   3155 C CG  . ASN A 1 441 ? 176.93600 367.35700 40.11200  1.000 37.03936  ? 476 ASN F CG  1 
ATOM   3156 O OD1 . ASN A 1 441 ? 177.07900 367.87200 39.00100  1.000 38.33062  ? 476 ASN F OD1 1 
ATOM   3157 N ND2 . ASN A 1 441 ? 175.74800 367.11000 40.63600  1.000 41.63165  ? 476 ASN F ND2 1 
ATOM   3158 N N   . PHE A 1 442 ? 181.28000 365.73200 41.37900  1.000 44.58460  ? 477 PHE F N   1 
ATOM   3159 C CA  . PHE A 1 442 ? 182.40900 365.65400 42.30200  1.000 37.92285  ? 477 PHE F CA  1 
ATOM   3160 C C   . PHE A 1 442 ? 183.70600 366.13000 41.67900  1.000 36.97534  ? 477 PHE F C   1 
ATOM   3161 O O   . PHE A 1 442 ? 184.75500 366.01700 42.32600  1.000 43.31456  ? 477 PHE F O   1 
ATOM   3162 C CB  . PHE A 1 442 ? 182.64200 364.21900 42.78400  1.000 40.68049  ? 477 PHE F CB  1 
ATOM   3163 C CG  . PHE A 1 442 ? 181.47600 363.60800 43.50200  1.000 44.32054  ? 477 PHE F CG  1 
ATOM   3164 C CD1 . PHE A 1 442 ? 180.60900 364.39100 44.25000  1.000 43.86880  ? 477 PHE F CD1 1 
ATOM   3165 C CD2 . PHE A 1 442 ? 181.27800 362.22600 43.46800  1.000 41.49907  ? 477 PHE F CD2 1 
ATOM   3166 C CE1 . PHE A 1 442 ? 179.54700 363.81300 44.92900  1.000 48.65639  ? 477 PHE F CE1 1 
ATOM   3167 C CE2 . PHE A 1 442 ? 180.21600 361.64600 44.13900  1.000 41.13834  ? 477 PHE F CE2 1 
ATOM   3168 C CZ  . PHE A 1 442 ? 179.34800 362.43800 44.87100  1.000 40.55897  ? 477 PHE F CZ  1 
ATOM   3169 N N   . TYR A 1 443 ? 183.66200 366.63800 40.45200  1.000 35.04845  ? 478 TYR F N   1 
ATOM   3170 C CA  . TYR A 1 443 ? 184.84900 366.98500 39.68400  1.000 29.66433  ? 478 TYR F CA  1 
ATOM   3171 C C   . TYR A 1 443 ? 184.92300 368.48800 39.45700  1.000 39.02677  ? 478 TYR F C   1 
ATOM   3172 O O   . TYR A 1 443 ? 183.91500 369.12600 39.12500  1.000 44.90493  ? 478 TYR F O   1 
ATOM   3173 C CB  . TYR A 1 443 ? 184.85200 366.26000 38.32900  1.000 33.04723  ? 478 TYR F CB  1 
ATOM   3174 C CG  . TYR A 1 443 ? 185.16500 364.76600 38.38900  1.000 38.01850  ? 478 TYR F CG  1 
ATOM   3175 C CD1 . TYR A 1 443 ? 186.46900 364.31900 38.48600  1.000 36.18620  ? 478 TYR F CD1 1 
ATOM   3176 C CD2 . TYR A 1 443 ? 184.15000 363.80500 38.33400  1.000 38.42413  ? 478 TYR F CD2 1 
ATOM   3177 C CE1 . TYR A 1 443 ? 186.75700 362.98000 38.55100  1.000 41.71416  ? 478 TYR F CE1 1 
ATOM   3178 C CE2 . TYR A 1 443 ? 184.43400 362.43900 38.39500  1.000 31.24286  ? 478 TYR F CE2 1 
ATOM   3179 C CZ  . TYR A 1 443 ? 185.73600 362.03600 38.50300  1.000 37.06637  ? 478 TYR F CZ  1 
ATOM   3180 O OH  . TYR A 1 443 ? 186.05800 360.68900 38.56900  1.000 41.29034  ? 478 TYR F OH  1 
ATOM   3181 N N   . ASP A 1 444 ? 186.09400 369.04900 39.71800  1.000 44.43876  ? 479 ASP F N   1 
ATOM   3182 C CA  . ASP A 1 444 ? 186.35800 370.44700 39.43400  1.000 40.85208  ? 479 ASP F CA  1 
ATOM   3183 C C   . ASP A 1 444 ? 186.54200 370.64200 37.92800  1.000 51.82580  ? 479 ASP F C   1 
ATOM   3184 O O   . ASP A 1 444 ? 187.41700 369.99300 37.32800  1.000 50.66731  ? 479 ASP F O   1 
ATOM   3185 C CB  . ASP A 1 444 ? 187.62000 370.85900 40.18000  1.000 46.30821  ? 479 ASP F CB  1 
ATOM   3186 C CG  . ASP A 1 444 ? 188.02800 372.30000 39.90500  1.000 57.61052  ? 479 ASP F CG  1 
ATOM   3187 O OD1 . ASP A 1 444 ? 187.14400 373.14800 39.63800  1.000 57.98402  ? 479 ASP F OD1 1 
ATOM   3188 O OD2 . ASP A 1 444 ? 189.24700 372.58500 39.96400  1.000 63.16475  ? 479 ASP F OD2 1 
ATOM   3189 N N   . PRO A 1 445 ? 185.79900 371.56100 37.29400  1.000 50.94992  ? 480 PRO F N   1 
ATOM   3190 C CA  . PRO A 1 445 ? 185.91700 371.70000 35.83100  1.000 43.91379  ? 480 PRO F CA  1 
ATOM   3191 C C   . PRO A 1 445 ? 187.30100 372.12300 35.37300  1.000 49.65332  ? 480 PRO F C   1 
ATOM   3192 O O   . PRO A 1 445 ? 187.72900 371.70700 34.29200  1.000 49.64006  ? 480 PRO F O   1 
ATOM   3193 C CB  . PRO A 1 445 ? 184.87000 372.76800 35.50400  1.000 43.65342  ? 480 PRO F CB  1 
ATOM   3194 C CG  . PRO A 1 445 ? 183.85200 372.64600 36.59600  1.000 46.23623  ? 480 PRO F CG  1 
ATOM   3195 C CD  . PRO A 1 445 ? 184.41100 371.79400 37.71700  1.000 38.63538  ? 480 PRO F CD  1 
ATOM   3196 N N   . LEU A 1 446 ? 187.98600 373.00200 36.11700  1.000 56.16992  ? 481 LEU F N   1 
ATOM   3197 C CA  . LEU A 1 446 ? 189.25500 373.53800 35.62600  1.000 57.76163  ? 481 LEU F CA  1 
ATOM   3198 C C   . LEU A 1 446 ? 190.28300 372.43800 35.38400  1.000 54.33998  ? 481 LEU F C   1 
ATOM   3199 O O   . LEU A 1 446 ? 191.06100 372.53300 34.43000  1.000 63.14792  ? 481 LEU F O   1 
ATOM   3200 C CB  . LEU A 1 446 ? 189.78400 374.65600 36.53400  1.000 62.31137  ? 481 LEU F CB  1 
ATOM   3201 C CG  . LEU A 1 446 ? 188.78600 375.83400 36.69300  1.000 66.31907  ? 481 LEU F CG  1 
ATOM   3202 C CD1 . LEU A 1 446 ? 188.05800 376.11500 35.36200  1.000 54.72254  ? 481 LEU F CD1 1 
ATOM   3203 C CD2 . LEU A 1 446 ? 187.76600 375.70700 37.82500  1.000 64.33478  ? 481 LEU F CD2 1 
ATOM   3204 N N   . VAL A 1 447 ? 190.37200 371.42600 36.25000  1.000 54.74413  ? 482 VAL F N   1 
ATOM   3205 C CA  . VAL A 1 447 ? 191.41500 370.41300 36.05300  1.000 55.42981  ? 482 VAL F CA  1 
ATOM   3206 C C   . VAL A 1 447 ? 190.87600 369.09300 35.44400  1.000 46.90894  ? 482 VAL F C   1 
ATOM   3207 O O   . VAL A 1 447 ? 191.61600 368.10700 35.39300  1.000 51.99863  ? 482 VAL F O   1 
ATOM   3208 C CB  . VAL A 1 447 ? 192.15900 370.13700 37.38300  1.000 55.92082  ? 482 VAL F CB  1 
ATOM   3209 C CG1 . VAL A 1 447 ? 192.91200 371.36800 37.86300  1.000 61.73336  ? 482 VAL F CG1 1 
ATOM   3210 C CG2 . VAL A 1 447 ? 191.19800 369.68300 38.47300  1.000 41.58311  ? 482 VAL F CG2 1 
ATOM   3211 N N   . PHE A 1 448 ? 189.60800 369.05000 34.98300  1.000 49.68831  ? 483 PHE F N   1 
ATOM   3212 C CA  . PHE A 1 448 ? 189.01000 367.81400 34.42900  1.000 44.41362  ? 483 PHE F CA  1 
ATOM   3213 C C   . PHE A 1 448 ? 189.65300 367.49500 33.06500  1.000 43.87441  ? 483 PHE F C   1 
ATOM   3214 O O   . PHE A 1 448 ? 189.70900 368.37700 32.20100  1.000 47.95732  ? 483 PHE F O   1 
ATOM   3215 C CB  . PHE A 1 448 ? 187.50000 368.01100 34.25200  1.000 40.91431  ? 483 PHE F CB  1 
ATOM   3216 C CG  . PHE A 1 448 ? 186.71100 366.74300 34.01300  1.000 36.41530  ? 483 PHE F CG  1 
ATOM   3217 C CD1 . PHE A 1 448 ? 186.68400 365.75300 34.99000  1.000 35.09031  ? 483 PHE F CD1 1 
ATOM   3218 C CD2 . PHE A 1 448 ? 186.06300 366.50700 32.80900  1.000 35.72762  ? 483 PHE F CD2 1 
ATOM   3219 C CE1 . PHE A 1 448 ? 185.95500 364.58700 34.82100  1.000 34.67861  ? 483 PHE F CE1 1 
ATOM   3220 C CE2 . PHE A 1 448 ? 185.34800 365.33100 32.60800  1.000 35.50686  ? 483 PHE F CE2 1 
ATOM   3221 C CZ  . PHE A 1 448 ? 185.29800 364.35700 33.62000  1.000 33.59355  ? 483 PHE F CZ  1 
ATOM   3222 N N   . PRO A 1 449 ? 189.97900 366.21500 32.75900  1.000 40.70781  ? 484 PRO F N   1 
ATOM   3223 C CA  . PRO A 1 449 ? 190.39400 365.83100 31.38800  1.000 38.70109  ? 484 PRO F CA  1 
ATOM   3224 C C   . PRO A 1 449 ? 189.18300 365.61600 30.48300  1.000 43.87739  ? 484 PRO F C   1 
ATOM   3225 O O   . PRO A 1 449 ? 188.56500 364.54700 30.51800  1.000 45.17400  ? 484 PRO F O   1 
ATOM   3226 C CB  . PRO A 1 449 ? 191.16900 364.52500 31.61300  1.000 35.99358  ? 484 PRO F CB  1 
ATOM   3227 C CG  . PRO A 1 449 ? 191.32500 364.38900 33.09500  1.000 43.51131  ? 484 PRO F CG  1 
ATOM   3228 C CD  . PRO A 1 449 ? 190.18700 365.12600 33.72100  1.000 38.92702  ? 484 PRO F CD  1 
ATOM   3229 N N   . SER A 1 450 ? 188.91500 366.57100 29.58000  1.000 38.29483  ? 485 SER F N   1 
ATOM   3230 C CA  . SER A 1 450 ? 187.66500 366.52700 28.82600  1.000 35.73816  ? 485 SER F CA  1 
ATOM   3231 C C   . SER A 1 450 ? 187.73000 365.87900 27.45500  1.000 44.98320  ? 485 SER F C   1 
ATOM   3232 O O   . SER A 1 450 ? 186.78400 366.03400 26.66100  1.000 52.18685  ? 485 SER F O   1 
ATOM   3233 C CB  . SER A 1 450 ? 187.15000 367.94500 28.61500  1.000 39.27639  ? 485 SER F CB  1 
ATOM   3234 O OG  . SER A 1 450 ? 186.85100 368.57400 29.83900  1.000 57.95605  ? 485 SER F OG  1 
ATOM   3235 N N   . ASP A 1 451 ? 188.77600 365.16200 27.13100  1.000 32.95871  ? 486 ASP F N   1 
ATOM   3236 C CA  . ASP A 1 451 ? 188.77900 364.57700 25.79900  1.000 33.79111  ? 486 ASP F CA  1 
ATOM   3237 C C   . ASP A 1 451 ? 189.32000 363.17000 25.86800  1.000 33.30275  ? 486 ASP F C   1 
ATOM   3238 O O   . ASP A 1 451 ? 190.10300 362.75400 25.00800  1.000 40.44329  ? 486 ASP F O   1 
ATOM   3239 C CB  . ASP A 1 451 ? 189.50300 365.43200 24.76500  1.000 40.25117  ? 486 ASP F CB  1 
ATOM   3240 C CG  . ASP A 1 451 ? 188.82100 365.37000 23.38100  1.000 42.71903  ? 486 ASP F CG  1 
ATOM   3241 O OD1 . ASP A 1 451 ? 188.01700 364.42900 23.12000  1.000 40.86710  ? 486 ASP F OD1 1 
ATOM   3242 O OD2 . ASP A 1 451 ? 189.06900 366.27600 22.55300  1.000 40.80522  ? 486 ASP F OD2 1 
ATOM   3243 N N   . GLU A 1 452 ? 189.02100 362.43900 26.93400  1.000 30.95288  ? 487 GLU F N   1 
ATOM   3244 C CA  . GLU A 1 452 ? 189.52900 361.08400 26.95400  1.000 37.55396  ? 487 GLU F CA  1 
ATOM   3245 C C   . GLU A 1 452 ? 188.53200 360.18000 26.24800  1.000 36.15063  ? 487 GLU F C   1 
ATOM   3246 O O   . GLU A 1 452 ? 187.33500 360.21500 26.53700  1.000 37.56314  ? 487 GLU F O   1 
ATOM   3247 C CB  . GLU A 1 452 ? 189.70900 360.62500 28.40600  1.000 34.40975  ? 487 GLU F CB  1 
ATOM   3248 C CG  . GLU A 1 452 ? 190.63700 361.54600 29.24800  1.000 36.34780  ? 487 GLU F CG  1 
ATOM   3249 C CD  . GLU A 1 452 ? 192.10900 361.42100 28.92600  1.000 40.61794  ? 487 GLU F CD  1 
ATOM   3250 O OE1 . GLU A 1 452 ? 192.64000 360.29800 28.93000  1.000 48.26574  ? 487 GLU F OE1 1 
ATOM   3251 O OE2 . GLU A 1 452 ? 192.76200 362.47500 28.73800  1.000 46.12449  ? 487 GLU F OE2 1 
ATOM   3252 N N   . PHE A 1 453 ? 189.05600 359.24700 25.46200  1.000 29.07188  ? 488 PHE F N   1 
ATOM   3253 C CA  . PHE A 1 453 ? 188.19200 358.40500 24.66900  1.000 37.74013  ? 488 PHE F CA  1 
ATOM   3254 C C   . PHE A 1 453 ? 188.11000 356.96500 25.16100  1.000 36.62569  ? 488 PHE F C   1 
ATOM   3255 O O   . PHE A 1 453 ? 187.18700 356.24600 24.76200  1.000 34.94491  ? 488 PHE F O   1 
ATOM   3256 C CB  . PHE A 1 453 ? 188.61900 358.51700 23.18600  1.000 39.73774  ? 488 PHE F CB  1 
ATOM   3257 C CG  . PHE A 1 453 ? 189.44400 357.40100 22.68200  1.000 36.00286  ? 488 PHE F CG  1 
ATOM   3258 C CD1 . PHE A 1 453 ? 190.80100 357.35700 22.96100  1.000 41.01841  ? 488 PHE F CD1 1 
ATOM   3259 C CD2 . PHE A 1 453 ? 188.87000 356.40900 21.88100  1.000 41.20159  ? 488 PHE F CD2 1 
ATOM   3260 C CE1 . PHE A 1 453 ? 191.59500 356.29200 22.49600  1.000 49.78850  ? 488 PHE F CE1 1 
ATOM   3261 C CE2 . PHE A 1 453 ? 189.62900 355.34000 21.39900  1.000 42.36685  ? 488 PHE F CE2 1 
ATOM   3262 C CZ  . PHE A 1 453 ? 191.00400 355.28100 21.70200  1.000 54.12133  ? 488 PHE F CZ  1 
ATOM   3263 N N   . ASP A 1 454 ? 189.01400 356.55200 26.04100  1.000 36.42922  ? 489 ASP F N   1 
ATOM   3264 C CA  . ASP A 1 454 ? 189.11300 355.22000 26.62600  1.000 36.65489  ? 489 ASP F CA  1 
ATOM   3265 C C   . ASP A 1 454 ? 189.77000 355.30800 27.99200  1.000 35.62636  ? 489 ASP F C   1 
ATOM   3266 O O   . ASP A 1 454 ? 190.82700 354.72300 28.23100  1.000 50.13516  ? 489 ASP F O   1 
ATOM   3267 C CB  . ASP A 1 454 ? 189.85300 354.20300 25.76200  1.000 47.80109  ? 489 ASP F CB  1 
ATOM   3268 C CG  . ASP A 1 454 ? 189.36300 352.77600 26.01700  1.000 46.68184  ? 489 ASP F CG  1 
ATOM   3269 O OD1 . ASP A 1 454 ? 188.62900 352.55500 27.00800  1.000 49.53215  ? 489 ASP F OD1 1 
ATOM   3270 O OD2 . ASP A 1 454 ? 189.76300 351.85800 25.27900  1.000 62.50941  ? 489 ASP F OD2 1 
ATOM   3271 N N   . ALA A 1 455 ? 189.17900 356.06400 28.89700  1.000 30.11634  ? 490 ALA F N   1 
ATOM   3272 C CA  . ALA A 1 455 ? 189.83000 356.29400 30.16700  1.000 33.75342  ? 490 ALA F CA  1 
ATOM   3273 C C   . ALA A 1 455 ? 189.21600 355.37500 31.22100  1.000 38.61439  ? 490 ALA F C   1 
ATOM   3274 O O   . ALA A 1 455 ? 188.42500 354.46500 30.92000  1.000 37.14685  ? 490 ALA F O   1 
ATOM   3275 C CB  . ALA A 1 455 ? 189.76900 357.76600 30.57400  1.000 36.75087  ? 490 ALA F CB  1 
ATOM   3276 N N   . SER A 1 456 ? 189.59900 355.61200 32.47100  1.000 35.84682  ? 491 SER F N   1 
ATOM   3277 C CA  . SER A 1 456 ? 189.14500 354.87200 33.63600  1.000 38.66766  ? 491 SER F CA  1 
ATOM   3278 C C   . SER A 1 456 ? 188.99600 355.83100 34.79600  1.000 38.79074  ? 491 SER F C   1 
ATOM   3279 O O   . SER A 1 456 ? 189.56400 356.92400 34.79400  1.000 37.85839  ? 491 SER F O   1 
ATOM   3280 C CB  . SER A 1 456 ? 190.09800 353.72800 33.99200  1.000 40.17290  ? 491 SER F CB  1 
ATOM   3281 O OG  . SER A 1 456 ? 191.24500 354.22600 34.66200  1.000 43.48668  ? 491 SER F OG  1 
ATOM   3282 N N   . ILE A 1 457 ? 188.22800 355.41100 35.79700  1.000 38.79446  ? 492 ILE F N   1 
ATOM   3283 C CA  . ILE A 1 457 ? 188.02500 356.27400 36.95100  1.000 38.76517  ? 492 ILE F CA  1 
ATOM   3284 C C   . ILE A 1 457 ? 189.35800 356.60600 37.61800  1.000 34.44164  ? 492 ILE F C   1 
ATOM   3285 O O   . ILE A 1 457 ? 189.66600 357.77300 37.85600  1.000 39.75932  ? 492 ILE F O   1 
ATOM   3286 C CB  . ILE A 1 457 ? 187.09200 355.55800 37.94400  1.000 36.13031  ? 492 ILE F CB  1 
ATOM   3287 C CG1 . ILE A 1 457 ? 185.64100 355.75200 37.53700  1.000 29.65626  ? 492 ILE F CG1 1 
ATOM   3288 C CG2 . ILE A 1 457 ? 187.33000 356.05400 39.37700  1.000 30.74002  ? 492 ILE F CG2 1 
ATOM   3289 C CD1 . ILE A 1 457 ? 185.18200 357.14100 37.69200  1.000 32.29064  ? 492 ILE F CD1 1 
ATOM   3290 N N   . SER A 1 458 ? 190.22800 355.65300 37.80400  1.000 41.83882  ? 493 SER F N   1 
ATOM   3291 C CA  . SER A 1 458 ? 191.47700 355.94500 38.46200  1.000 44.25821  ? 493 SER F CA  1 
ATOM   3292 C C   . SER A 1 458 ? 192.46000 356.62700 37.53900  1.000 43.57201  ? 493 SER F C   1 
ATOM   3293 O O   . SER A 1 458 ? 193.39700 357.26100 37.98300  1.000 43.33533  ? 493 SER F O   1 
ATOM   3294 C CB  . SER A 1 458 ? 192.06100 354.65800 39.01600  1.000 41.78900  ? 493 SER F CB  1 
ATOM   3295 O OG  . SER A 1 458 ? 191.08500 353.95100 39.75400  1.000 51.17823  ? 493 SER F OG  1 
ATOM   3296 N N   . GLN A 1 459 ? 192.24700 356.50800 36.25100  1.000 39.37721  ? 494 GLN F N   1 
ATOM   3297 C CA  . GLN A 1 459 ? 193.09300 357.18000 35.30100  1.000 42.51834  ? 494 GLN F CA  1 
ATOM   3298 C C   . GLN A 1 459 ? 192.82100 358.64500 35.33800  1.000 46.36978  ? 494 GLN F C   1 
ATOM   3299 O O   . GLN A 1 459 ? 193.73000 359.44800 35.38100  1.000 50.96357  ? 494 GLN F O   1 
ATOM   3300 C CB  . GLN A 1 459 ? 192.76900 356.68600 33.91200  1.000 41.94042  ? 494 GLN F CB  1 
ATOM   3301 C CG  . GLN A 1 459 ? 193.68400 355.62600 33.34300  1.000 45.34575  ? 494 GLN F CG  1 
ATOM   3302 C CD  . GLN A 1 459 ? 193.19300 355.11500 32.00500  1.000 44.89999  ? 494 GLN F CD  1 
ATOM   3303 O OE1 . GLN A 1 459 ? 192.67200 354.01100 31.90500  1.000 44.75971  ? 494 GLN F OE1 1 
ATOM   3304 N NE2 . GLN A 1 459 ? 193.35700 355.92100 30.97000  1.000 42.87168  ? 494 GLN F NE2 1 
ATOM   3305 N N   . VAL A 1 460 ? 191.55800 359.00100 35.30700  1.000 43.22512  ? 495 VAL F N   1 
ATOM   3306 C CA  . VAL A 1 460 ? 191.16900 360.38100 35.34800  1.000 42.59693  ? 495 VAL F CA  1 
ATOM   3307 C C   . VAL A 1 460 ? 191.60300 361.01000 36.65900  1.000 45.33593  ? 495 VAL F C   1 
ATOM   3308 O O   . VAL A 1 460 ? 192.02400 362.15100 36.68400  1.000 46.39416  ? 495 VAL F O   1 
ATOM   3309 C CB  . VAL A 1 460 ? 189.64800 360.50500 35.15300  1.000 40.19276  ? 495 VAL F CB  1 
ATOM   3310 C CG1 . VAL A 1 460 ? 189.12000 361.81300 35.70800  1.000 42.80880  ? 495 VAL F CG1 1 
ATOM   3311 C CG2 . VAL A 1 460 ? 189.29100 360.35400 33.68800  1.000 37.66265  ? 495 VAL F CG2 1 
ATOM   3312 N N   . ASN A 1 461 ? 191.53700 360.26100 37.74300  1.000 40.60245  ? 496 ASN F N   1 
ATOM   3313 C CA  . ASN A 1 461 ? 191.99600 360.82500 39.01000  1.000 43.03556  ? 496 ASN F CA  1 
ATOM   3314 C C   . ASN A 1 461 ? 193.50100 361.08200 38.95500  1.000 55.99754  ? 496 ASN F C   1 
ATOM   3315 O O   . ASN A 1 461 ? 194.00400 362.00800 39.60000  1.000 59.43316  ? 496 ASN F O   1 
ATOM   3316 C CB  . ASN A 1 461 ? 191.60400 359.92900 40.17300  1.000 43.72149  ? 496 ASN F CB  1 
ATOM   3317 C CG  . ASN A 1 461 ? 190.12400 360.00800 40.47500  1.000 49.74383  ? 496 ASN F CG  1 
ATOM   3318 O OD1 . ASN A 1 461 ? 189.30700 360.37400 39.61100  1.000 53.28424  ? 496 ASN F OD1 1 
ATOM   3319 N ND2 . ASN A 1 461 ? 189.75500 359.62600 41.68500  1.000 51.73733  ? 496 ASN F ND2 1 
ATOM   3320 N N   . GLU A 1 462 ? 194.24500 360.21900 38.25500  1.000 53.12577  ? 497 GLU F N   1 
ATOM   3321 C CA  . GLU A 1 462 ? 195.67400 360.43800 38.08700  1.000 53.01118  ? 497 GLU F CA  1 
ATOM   3322 C C   . GLU A 1 462 ? 195.95600 361.67300 37.24400  1.000 60.96775  ? 497 GLU F C   1 
ATOM   3323 O O   . GLU A 1 462 ? 196.89400 362.41900 37.52900  1.000 68.98541  ? 497 GLU F O   1 
ATOM   3324 C CB  . GLU A 1 462 ? 196.27800 359.23100 37.36100  1.000 51.13176  ? 497 GLU F CB  1 
ATOM   3325 C CG  . GLU A 1 462 ? 197.75400 359.33600 37.04600  1.000 65.10076  ? 497 GLU F CG  1 
ATOM   3326 C CD  . GLU A 1 462 ? 198.23100 358.35600 35.94800  1.000 81.16003  ? 497 GLU F CD  1 
ATOM   3327 O OE1 . GLU A 1 462 ? 197.39200 357.77900 35.19300  1.000 73.50511  ? 497 GLU F OE1 1 
ATOM   3328 O OE2 . GLU A 1 462 ? 199.47100 358.17500 35.84300  1.000 81.42671  ? 497 GLU F OE2 1 
ATOM   3329 N N   . LYS A 1 463 ? 195.14200 361.92700 36.21900  1.000 58.16486  ? 498 LYS F N   1 
ATOM   3330 C CA  . LYS A 1 463 ? 195.29400 363.15300 35.43600  1.000 56.52482  ? 498 LYS F CA  1 
ATOM   3331 C C   . LYS A 1 463 ? 194.96800 364.39700 36.26200  1.000 61.99408  ? 498 LYS F C   1 
ATOM   3332 O O   . LYS A 1 463 ? 195.53200 365.46800 36.01700  1.000 67.61402  ? 498 LYS F O   1 
ATOM   3333 C CB  . LYS A 1 463 ? 194.47800 363.08200 34.14400  1.000 45.07313  ? 498 LYS F CB  1 
ATOM   3334 C CG  . LYS A 1 463 ? 195.23400 362.35600 33.02200  1.000 46.26194  ? 498 LYS F CG  1 
ATOM   3335 C CD  . LYS A 1 463 ? 194.40800 362.20700 31.74900  1.000 47.68458  ? 498 LYS F CD  1 
ATOM   3336 C CE  . LYS A 1 463 ? 195.15500 361.44800 30.61400  1.000 47.93550  ? 498 LYS F CE  1 
ATOM   3337 N NZ  . LYS A 1 463 ? 195.12500 359.93600 30.76500  1.000 51.74465  ? 498 LYS F NZ  1 
ATOM   3338 N N   . ILE A 1 464 ? 194.09600 364.26400 37.26300  1.000 58.88301  ? 499 ILE F N   1 
ATOM   3339 C CA  . ILE A 1 464 ? 193.76600 365.38600 38.13200  1.000 61.44990  ? 499 ILE F CA  1 
ATOM   3340 C C   . ILE A 1 464 ? 194.89300 365.64400 39.11800  1.000 70.03916  ? 499 ILE F C   1 
ATOM   3341 O O   . ILE A 1 464 ? 195.15700 366.79600 39.47900  1.000 73.88171  ? 499 ILE F O   1 
ATOM   3342 C CB  . ILE A 1 464 ? 192.42600 365.09500 38.85000  1.000 51.81560  ? 499 ILE F CB  1 
ATOM   3343 C CG1 . ILE A 1 464 ? 191.29500 364.92900 37.83100  1.000 49.42252  ? 499 ILE F CG1 1 
ATOM   3344 C CG2 . ILE A 1 464 ? 192.09500 366.14600 39.90900  1.000 48.62530  ? 499 ILE F CG2 1 
ATOM   3345 C CD1 . ILE A 1 464 ? 189.94500 364.57700 38.43500  1.000 44.73764  ? 499 ILE F CD1 1 
ATOM   3346 N N   . ASN A 1 465 ? 195.53500 364.58500 39.61300  1.000 70.63625  ? 500 ASN F N   1 
ATOM   3347 C CA  . ASN A 1 465 ? 196.69000 364.74600 40.49400  1.000 74.64554  ? 500 ASN F CA  1 
ATOM   3348 C C   . ASN A 1 465 ? 197.88900 365.35000 39.76400  1.000 77.71603  ? 500 ASN F C   1 
ATOM   3349 O O   . ASN A 1 465 ? 198.67200 366.09100 40.36600  1.000 84.12203  ? 500 ASN F O   1 
ATOM   3350 C CB  . ASN A 1 465 ? 197.03700 363.38600 41.07800  1.000 75.39892  ? 500 ASN F CB  1 
ATOM   3351 C CG  . ASN A 1 465 ? 196.10200 362.99200 42.18300  1.000 80.68655  ? 500 ASN F CG  1 
ATOM   3352 O OD1 . ASN A 1 465 ? 195.02500 363.57000 42.33000  1.000 82.97456  ? 500 ASN F OD1 1 
ATOM   3353 N ND2 . ASN A 1 465 ? 196.46400 361.95800 42.92100  1.000 87.38442  ? 500 ASN F ND2 1 
ATOM   3354 N N   . GLN A 1 466 ? 198.04000 365.05400 38.47000  1.000 77.93626  ? 501 GLN F N   1 
ATOM   3355 C CA  . GLN A 1 466 ? 199.11500 365.63400 37.67000  1.000 84.48474  ? 501 GLN F CA  1 
ATOM   3356 C C   . GLN A 1 466 ? 198.81400 367.07400 37.27700  1.000 93.31421  ? 501 GLN F C   1 
ATOM   3357 O O   . GLN A 1 466 ? 199.74800 367.86000 37.07800  1.000 100.84300 ? 501 GLN F O   1 
ATOM   3358 C CB  . GLN A 1 466 ? 199.38000 364.77200 36.43500  1.000 83.79713  ? 501 GLN F CB  1 
ATOM   3359 C CG  . GLN A 1 466 ? 199.91900 363.39700 36.77900  1.000 79.76607  ? 501 GLN F CG  1 
ATOM   3360 C CD  . GLN A 1 466 ? 200.10100 362.52800 35.55600  1.000 87.78347  ? 501 GLN F CD  1 
ATOM   3361 O OE1 . GLN A 1 466 ? 200.04300 363.01100 34.42700  1.000 90.50011  ? 501 GLN F OE1 1 
ATOM   3362 N NE2 . GLN A 1 466 ? 200.30100 361.23000 35.77300  1.000 91.11654  ? 501 GLN F NE2 1 
ATOM   3363 N N   . SER A 1 467 ? 197.53900 367.42200 37.08300  1.000 89.36110  ? 502 SER F N   1 
ATOM   3364 C CA  . SER A 1 467 ? 197.21800 368.80800 36.77800  1.000 93.62082  ? 502 SER F CA  1 
ATOM   3365 C C   . SER A 1 467 ? 197.23000 369.65200 38.04400  1.000 97.10917  ? 502 SER F C   1 
ATOM   3366 O O   . SER A 1 467 ? 197.40900 370.87400 37.96300  1.000 101.37153 ? 502 SER F O   1 
ATOM   3367 C CB  . SER A 1 467 ? 195.85000 368.92700 36.09300  1.000 82.82714  ? 502 SER F CB  1 
ATOM   3368 O OG  . SER A 1 467 ? 195.85700 368.35900 34.79400  1.000 88.04914  ? 502 SER F OG  1 
ATOM   3369 N N   . LEU A 1 468 ? 197.01200 369.02100 39.20900  1.000 91.76736  ? 503 LEU F N   1 
ATOM   3370 C CA  . LEU A 1 468 ? 197.10500 369.73900 40.47000  1.000 91.71323  ? 503 LEU F CA  1 
ATOM   3371 C C   . LEU A 1 468 ? 198.55500 369.93300 40.90900  1.000 105.88947 ? 503 LEU F C   1 
ATOM   3372 O O   . LEU A 1 468 ? 198.84100 370.88100 41.65300  1.000 112.13002 ? 503 LEU F O   1 
ATOM   3373 C CB  . LEU A 1 468 ? 196.33400 368.96600 41.54700  1.000 83.88335  ? 503 LEU F CB  1 
ATOM   3374 C CG  . LEU A 1 468 ? 194.79600 368.98700 41.57400  1.000 76.53170  ? 503 LEU F CG  1 
ATOM   3375 C CD1 . LEU A 1 468 ? 194.26700 368.14400 42.72500  1.000 70.74523  ? 503 LEU F CD1 1 
ATOM   3376 C CD2 . LEU A 1 468 ? 194.22500 370.39700 41.64300  1.000 75.61746  ? 503 LEU F CD2 1 
ATOM   3377 N N   . ALA A 1 469 ? 199.47300 369.01300 40.53700  1.000 110.27561 ? 504 ALA F N   1 
ATOM   3378 C CA  . ALA A 1 469 ? 200.89200 369.24600 40.82500  1.000 112.37033 ? 504 ALA F CA  1 
ATOM   3379 C C   . ALA A 1 469 ? 201.49200 370.35000 39.94600  1.000 118.86635 ? 504 ALA F C   1 
ATOM   3380 O O   . ALA A 1 469 ? 202.39600 371.06800 40.38900  1.000 125.44522 ? 504 ALA F O   1 
ATOM   3381 C CB  . ALA A 1 469 ? 201.68200 367.94400 40.66600  1.000 98.05112  ? 504 ALA F CB  1 
ATOM   3382 N N   . PHE A 1 470 ? 201.02200 370.47700 38.69200  1.000 116.05039 ? 505 PHE F N   1 
ATOM   3383 C CA  . PHE A 1 470 ? 201.44100 371.54400 37.77900  1.000 119.30803 ? 505 PHE F CA  1 
ATOM   3384 C C   . PHE A 1 470 ? 200.92700 372.93300 38.17700  1.000 125.10421 ? 505 PHE F C   1 
ATOM   3385 O O   . PHE A 1 470 ? 201.46700 373.92500 37.67700  1.000 128.86351 ? 505 PHE F O   1 
ATOM   3386 C CB  . PHE A 1 470 ? 201.10000 371.24000 36.30100  1.000 122.11433 ? 505 PHE F CB  1 
ATOM   3387 C CG  . PHE A 1 470 ? 201.74300 369.97000 35.73700  1.000 121.87876 ? 505 PHE F CG  1 
ATOM   3388 C CD1 . PHE A 1 470 ? 202.97700 369.52300 36.20300  1.000 122.70822 ? 505 PHE F CD1 1 
ATOM   3389 C CD2 . PHE A 1 470 ? 201.14300 369.27200 34.68600  1.000 118.42030 ? 505 PHE F CD2 1 
ATOM   3390 C CE1 . PHE A 1 470 ? 203.57800 368.37300 35.66300  1.000 124.50931 ? 505 PHE F CE1 1 
ATOM   3391 C CE2 . PHE A 1 470 ? 201.73800 368.12100 34.14500  1.000 117.75253 ? 505 PHE F CE2 1 
ATOM   3392 C CZ  . PHE A 1 470 ? 202.95400 367.67500 34.63400  1.000 119.14320 ? 505 PHE F CZ  1 
ATOM   3393 N N   . ILE A 1 471 ? 199.88900 373.04500 39.03100  1.000 125.65122 ? 506 ILE F N   1 
ATOM   3394 C CA  . ILE A 1 471 ? 199.41400 374.37400 39.43700  1.000 125.76683 ? 506 ILE F CA  1 
ATOM   3395 C C   . ILE A 1 471 ? 200.01900 374.74700 40.79000  1.000 127.67373 ? 506 ILE F C   1 
ATOM   3396 O O   . ILE A 1 471 ? 200.15600 375.93600 41.10400  1.000 131.44190 ? 506 ILE F O   1 
ATOM   3397 C CB  . ILE A 1 471 ? 197.87000 374.46900 39.47200  1.000 120.40177 ? 506 ILE F CB  1 
ATOM   3398 C CG1 . ILE A 1 471 ? 197.30200 373.95200 40.79900  1.000 112.47525 ? 506 ILE F CG1 1 
ATOM   3399 C CG2 . ILE A 1 471 ? 197.23700 373.76500 38.25500  1.000 110.76281 ? 506 ILE F CG2 1 
ATOM   3400 C CD1 . ILE A 1 471 ? 195.79300 374.05700 40.89400  1.000 100.84727 ? 506 ILE F CD1 1 
ATOM   3401 N N   . ARG A 1 472 ? 200.33600 373.74800 41.62200  1.000 127.29578 ? 507 ARG F N   1 
ATOM   3402 C CA  . ARG A 1 472 ? 200.98600 374.03000 42.90300  1.000 131.38184 ? 507 ARG F CA  1 
ATOM   3403 C C   . ARG A 1 472 ? 202.36800 374.60400 42.61300  1.000 137.40531 ? 507 ARG F C   1 
ATOM   3404 O O   . ARG A 1 472 ? 202.82000 375.57400 43.23700  1.000 132.39293 ? 507 ARG F O   1 
ATOM   3405 C CB  . ARG A 1 472 ? 201.09200 372.79100 43.79100  1.000 123.26991 ? 507 ARG F CB  1 
ATOM   3406 C CG  . ARG A 1 472 ? 202.07800 373.01200 44.94300  1.000 125.01328 ? 507 ARG F CG  1 
ATOM   3407 C CD  . ARG A 1 472 ? 201.50400 373.99300 45.98400  1.000 130.20036 ? 507 ARG F CD  1 
ATOM   3408 N NE  . ARG A 1 472 ? 202.50100 374.83600 46.65000  1.000 131.53561 ? 507 ARG F NE  1 
ATOM   3409 C CZ  . ARG A 1 472 ? 202.93900 376.01200 46.20700  1.000 126.59172 ? 507 ARG F CZ  1 
ATOM   3410 N NH1 . ARG A 1 472 ? 202.49000 376.54200 45.08100  1.000 127.17435 ? 507 ARG F NH1 1 
ATOM   3411 N NH2 . ARG A 1 472 ? 203.84100 376.68100 46.92200  1.000 110.27178 ? 507 ARG F NH2 1 
ATOM   3412 N N   . LYS A 1 473 ? 203.02900 373.97300 41.63800  1.000 137.12150 ? 508 LYS F N   1 
ATOM   3413 C CA  . LYS A 1 473 ? 204.36100 374.26700 41.13100  1.000 132.69974 ? 508 LYS F CA  1 
ATOM   3414 C C   . LYS A 1 473 ? 204.39800 375.63100 40.45500  1.000 132.66182 ? 508 LYS F C   1 
ATOM   3415 O O   . LYS A 1 473 ? 205.45900 376.26200 40.37500  1.000 134.73487 ? 508 LYS F O   1 
ATOM   3416 C CB  . LYS A 1 473 ? 204.71400 373.19000 40.11100  1.000 130.99545 ? 508 LYS F CB  1 
ATOM   3417 C CG  . LYS A 1 473 ? 205.26900 371.90600 40.68300  1.000 139.56803 ? 508 LYS F CG  1 
ATOM   3418 C CD  . LYS A 1 473 ? 206.33000 372.08200 41.73700  1.000 137.76433 ? 508 LYS F CD  1 
ATOM   3419 C CE  . LYS A 1 473 ? 206.67900 370.71900 42.30600  1.000 130.97406 ? 508 LYS F CE  1 
ATOM   3420 N NZ  . LYS A 1 473 ? 207.65700 370.80300 43.40700  1.000 130.60700 ? 508 LYS F NZ  1 
ATOM   3421 N N   . SER A 1 474 ? 203.26000 376.06700 39.92400  1.000 135.96506 ? 509 SER F N   1 
ATOM   3422 C CA  . SER A 1 474 ? 203.11400 377.34400 39.24300  1.000 135.19905 ? 509 SER F CA  1 
ATOM   3423 C C   . SER A 1 474 ? 202.43700 378.37700 40.14900  1.000 130.87128 ? 509 SER F C   1 
ATOM   3424 O O   . SER A 1 474 ? 201.28500 378.76000 39.94300  1.000 125.36606 ? 509 SER F O   1 
ATOM   3425 C CB  . SER A 1 474 ? 202.26100 377.15500 37.98700  1.000 134.11842 ? 509 SER F CB  1 
ATOM   3426 O OG  . SER A 1 474 ? 202.77200 376.15800 37.12000  1.000 134.45800 ? 509 SER F OG  1 
HETATM 3427 C C1  . EDO B 2 .   ? 177.17800 352.68700 40.85800  1.000 40.25291  ? 601 EDO F C1  1 
HETATM 3428 O O1  . EDO B 2 .   ? 177.59400 354.00700 41.27600  1.000 42.35284  ? 601 EDO F O1  1 
HETATM 3429 C C2  . EDO B 2 .   ? 176.32200 352.68400 39.56800  1.000 39.41406  ? 601 EDO F C2  1 
HETATM 3430 O O2  . EDO B 2 .   ? 177.06800 352.95200 38.34200  1.000 36.62404  ? 601 EDO F O2  1 
HETATM 3431 H H11 . EDO B 2 .   ? 176.60200 352.22800 41.66400  1.000 48.53574  ? 601 EDO F H11 1 
HETATM 3432 H H12 . EDO B 2 .   ? 178.06700 352.07500 40.69100  1.000 48.53574  ? 601 EDO F H12 1 
HETATM 3433 H HO1 . EDO B 2 .   ? 178.49500 353.96600 41.62500  1.000 51.05566  ? 601 EDO F HO1 1 
HETATM 3434 H H21 . EDO B 2 .   ? 175.53900 353.43800 39.67000  1.000 47.52913  ? 601 EDO F H21 1 
HETATM 3435 H H22 . EDO B 2 .   ? 175.83900 351.70900 39.47500  1.000 47.52913  ? 601 EDO F H22 1 
HETATM 3436 H HO2 . EDO B 2 .   ? 176.56100 352.63800 37.58100  1.000 44.18110  ? 601 EDO F HO2 1 
HETATM 3437 C C1  . NAG C 3 .   ? 195.63600 361.46600 43.99000  1.000 94.23324  ? 602 NAG F C1  1 
HETATM 3438 C C2  . NAG C 3 .   ? 195.68000 359.91600 44.10300  1.000 100.15582 ? 602 NAG F C2  1 
HETATM 3439 C C3  . NAG C 3 .   ? 194.96200 359.45000 45.37800  1.000 102.01069 ? 602 NAG F C3  1 
HETATM 3440 C C4  . NAG C 3 .   ? 195.48100 360.18400 46.60900  1.000 107.23619 ? 602 NAG F C4  1 
HETATM 3441 C C5  . NAG C 3 .   ? 195.35800 361.69100 46.40300  1.000 106.02536 ? 602 NAG F C5  1 
HETATM 3442 C C6  . NAG C 3 .   ? 195.90000 362.51400 47.55700  1.000 105.20080 ? 602 NAG F C6  1 
HETATM 3443 C C7  . NAG C 3 .   ? 195.72800 358.43500 42.10400  1.000 81.66955  ? 602 NAG F C7  1 
HETATM 3444 C C8  . NAG C 3 .   ? 194.90800 357.86600 40.98100  1.000 63.54968  ? 602 NAG F C8  1 
HETATM 3445 N N2  . NAG C 3 .   ? 195.08500 359.27700 42.93100  1.000 93.63854  ? 602 NAG F N2  1 
HETATM 3446 O O3  . NAG C 3 .   ? 195.12600 358.04500 45.54100  1.000 103.52393 ? 602 NAG F O3  1 
HETATM 3447 O O4  . NAG C 3 .   ? 194.73200 359.79000 47.75500  1.000 106.60970 ? 602 NAG F O4  1 
HETATM 3448 O O5  . NAG C 3 .   ? 196.10000 362.06800 45.23500  1.000 102.73938 ? 602 NAG F O5  1 
HETATM 3449 O O6  . NAG C 3 .   ? 196.80900 361.78800 48.37700  1.000 98.63526  ? 602 NAG F O6  1 
HETATM 3450 O O7  . NAG C 3 .   ? 196.91700 358.15400 42.24400  1.000 87.11913  ? 602 NAG F O7  1 
HETATM 3451 O O   . HOH D 4 .   ? 172.70500 356.43100 41.29100  1.000 21.06553  ? 701 HOH F O   1 
HETATM 3452 O O   . HOH D 4 .   ? 166.577   363.919   18.500    1.000 31.25591  ? 702 HOH F O   1 
HETATM 3453 O O   . HOH D 4 .   ? 174.25500 342.61800 37.51900  1.000 31.44425  ? 703 HOH F O   1 
HETATM 3454 O O   . HOH D 4 .   ? 156.62300 362.28700 24.28200  1.000 23.20146  ? 704 HOH F O   1 
HETATM 3455 O O   . HOH D 4 .   ? 177.12700 356.85900 31.62900  1.000 22.07493  ? 705 HOH F O   1 
HETATM 3456 O O   . HOH D 4 .   ? 162.92000 369.30900 28.49200  1.000 19.70718  ? 706 HOH F O   1 
HETATM 3457 O O   . HOH D 4 .   ? 184.03100 349.47600 33.32200  1.000 25.14908  ? 707 HOH F O   1 
HETATM 3458 O O   . HOH D 4 .   ? 181.27700 350.94400 32.90000  1.000 28.33406  ? 708 HOH F O   1 
HETATM 3459 O O   . HOH D 4 .   ? 179.00300 338.34600 38.49500  1.000 33.80016  ? 709 HOH F O   1 
HETATM 3460 O O   . HOH D 4 .   ? 179.324   333.816   -7.390    1.000 43.22202  ? 710 HOH F O   1 
HETATM 3461 O O   . HOH D 4 .   ? 164.06000 370.63400 21.16800  1.000 27.33680  ? 711 HOH F O   1 
HETATM 3462 O O   . HOH D 4 .   ? 151.33700 314.01800 -21.15250 0.50  30.32992  ? 712 HOH F O   1 
# 
