data_8W3H
# 
_entry.id   8W3H 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W3H         pdb_00008w3h 10.2210/pdb8w3h/pdb 
WWPDB D_1000280344 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W3H 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jiang@scripps.edu 
_pdbx_contact_author.name_first         JIANG 
_pdbx_contact_author.name_last          ZHU 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0259-7157 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lee, Y.Z.'       1 ? 
'Stanfield, R.L.' 2 ? 
'Wilson, I.A.'    3 ? 
'Zhu, J.'         4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9939 
_citation.page_last                 9939 
_citation.title                     
'Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54287-x 
_citation.pdbx_database_id_PubMed   39550381 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lee, Y.Z.'       1  0000-0002-5651-863X 
primary 'Han, J.'         2  ?                   
primary 'Zhang, Y.N.'     3  0000-0001-9053-5890 
primary 'Ward, G.'        4  ?                   
primary 'Braz Gomes, K.'  5  ?                   
primary 'Auclair, S.'     6  ?                   
primary 'Stanfield, R.L.' 7  ?                   
primary 'He, L.'          8  ?                   
primary 'Wilson, I.A.'    9  0000-0002-6469-2419 
primary 'Zhu, J.'         10 0000-0003-0259-7157 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Prefusion-stabilized RSV F protein UFCR1-iSS' 55684.719 1   ? ? ? ? 
2 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose       221.208   1   ? ? ? ? 
3 non-polymer syn 1,2-ETHANEDIOL                                 62.068    3   ? ? ? ? 
4 water       nat water                                          18.015    203 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYCVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYCVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_strand_id                 F 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
3 1,2-ETHANEDIOL                           EDO 
4 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   ILE n 
1 4   LEU n 
1 5   PRO n 
1 6   SER n 
1 7   PRO n 
1 8   GLY n 
1 9   MET n 
1 10  PRO n 
1 11  ALA n 
1 12  LEU n 
1 13  LEU n 
1 14  SER n 
1 15  LEU n 
1 16  VAL n 
1 17  SER n 
1 18  LEU n 
1 19  LEU n 
1 20  SER n 
1 21  VAL n 
1 22  LEU n 
1 23  LEU n 
1 24  MET n 
1 25  GLY n 
1 26  CYS n 
1 27  VAL n 
1 28  ALA n 
1 29  GLU n 
1 30  GLN n 
1 31  ASN n 
1 32  ILE n 
1 33  THR n 
1 34  GLU n 
1 35  GLU n 
1 36  PHE n 
1 37  TYR n 
1 38  GLN n 
1 39  SER n 
1 40  THR n 
1 41  CYS n 
1 42  SER n 
1 43  ALA n 
1 44  VAL n 
1 45  SER n 
1 46  LYS n 
1 47  GLY n 
1 48  TYR n 
1 49  LEU n 
1 50  SER n 
1 51  ALA n 
1 52  LEU n 
1 53  ARG n 
1 54  THR n 
1 55  GLY n 
1 56  TRP n 
1 57  TYR n 
1 58  THR n 
1 59  SER n 
1 60  VAL n 
1 61  ILE n 
1 62  THR n 
1 63  ILE n 
1 64  GLU n 
1 65  LEU n 
1 66  SER n 
1 67  ASN n 
1 68  ILE n 
1 69  LYS n 
1 70  GLU n 
1 71  ASN n 
1 72  LYS n 
1 73  CYS n 
1 74  ASN n 
1 75  GLY n 
1 76  THR n 
1 77  ASP n 
1 78  ALA n 
1 79  LYS n 
1 80  VAL n 
1 81  LYS n 
1 82  LEU n 
1 83  ILE n 
1 84  LYS n 
1 85  GLN n 
1 86  GLU n 
1 87  LEU n 
1 88  ASP n 
1 89  LYS n 
1 90  TYR n 
1 91  LYS n 
1 92  ASN n 
1 93  ALA n 
1 94  VAL n 
1 95  THR n 
1 96  ASP n 
1 97  LEU n 
1 98  GLN n 
1 99  LEU n 
1 100 LEU n 
1 101 MET n 
1 102 GLN n 
1 103 SER n 
1 104 THR n 
1 105 PRO n 
1 106 ALA n 
1 107 THR n 
1 108 GLY n 
1 109 SER n 
1 110 GLY n 
1 111 SER n 
1 112 ALA n 
1 113 ILE n 
1 114 CYS n 
1 115 SER n 
1 116 GLY n 
1 117 VAL n 
1 118 ALA n 
1 119 VAL n 
1 120 CYS n 
1 121 LYS n 
1 122 VAL n 
1 123 LEU n 
1 124 HIS n 
1 125 LEU n 
1 126 GLU n 
1 127 GLY n 
1 128 GLU n 
1 129 VAL n 
1 130 ASN n 
1 131 LYS n 
1 132 ILE n 
1 133 LYS n 
1 134 SER n 
1 135 ALA n 
1 136 LEU n 
1 137 LEU n 
1 138 SER n 
1 139 THR n 
1 140 ASN n 
1 141 LYS n 
1 142 ALA n 
1 143 VAL n 
1 144 VAL n 
1 145 SER n 
1 146 LEU n 
1 147 SER n 
1 148 ASN n 
1 149 GLY n 
1 150 VAL n 
1 151 SER n 
1 152 VAL n 
1 153 LEU n 
1 154 THR n 
1 155 SER n 
1 156 LYS n 
1 157 VAL n 
1 158 LEU n 
1 159 ASP n 
1 160 LEU n 
1 161 LYS n 
1 162 ASN n 
1 163 TYR n 
1 164 ILE n 
1 165 ASP n 
1 166 LYS n 
1 167 GLN n 
1 168 LEU n 
1 169 LEU n 
1 170 PRO n 
1 171 ILE n 
1 172 VAL n 
1 173 ASN n 
1 174 LYS n 
1 175 GLN n 
1 176 SER n 
1 177 CYS n 
1 178 SER n 
1 179 ILE n 
1 180 PRO n 
1 181 ASN n 
1 182 ILE n 
1 183 GLU n 
1 184 THR n 
1 185 VAL n 
1 186 ILE n 
1 187 GLU n 
1 188 PHE n 
1 189 GLN n 
1 190 GLN n 
1 191 LYS n 
1 192 ASN n 
1 193 ASN n 
1 194 ARG n 
1 195 LEU n 
1 196 LEU n 
1 197 GLU n 
1 198 ILE n 
1 199 THR n 
1 200 ARG n 
1 201 GLU n 
1 202 PHE n 
1 203 SER n 
1 204 VAL n 
1 205 ASN n 
1 206 ALA n 
1 207 GLY n 
1 208 VAL n 
1 209 THR n 
1 210 THR n 
1 211 PRO n 
1 212 VAL n 
1 213 SER n 
1 214 THR n 
1 215 TYR n 
1 216 MET n 
1 217 LEU n 
1 218 THR n 
1 219 ASN n 
1 220 SER n 
1 221 GLU n 
1 222 LEU n 
1 223 LEU n 
1 224 SER n 
1 225 LEU n 
1 226 ILE n 
1 227 ASN n 
1 228 ASP n 
1 229 MET n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 ASN n 
1 234 ASP n 
1 235 GLN n 
1 236 LYS n 
1 237 LYS n 
1 238 LEU n 
1 239 MET n 
1 240 SER n 
1 241 ASN n 
1 242 ASN n 
1 243 VAL n 
1 244 GLN n 
1 245 ILE n 
1 246 VAL n 
1 247 ARG n 
1 248 GLN n 
1 249 GLN n 
1 250 SER n 
1 251 TYR n 
1 252 SER n 
1 253 ILE n 
1 254 MET n 
1 255 CYS n 
1 256 ILE n 
1 257 ILE n 
1 258 LYS n 
1 259 GLU n 
1 260 GLU n 
1 261 VAL n 
1 262 LEU n 
1 263 ALA n 
1 264 TYR n 
1 265 VAL n 
1 266 VAL n 
1 267 GLN n 
1 268 LEU n 
1 269 PRO n 
1 270 LEU n 
1 271 TYR n 
1 272 GLY n 
1 273 VAL n 
1 274 ILE n 
1 275 ASP n 
1 276 THR n 
1 277 PRO n 
1 278 CYS n 
1 279 TRP n 
1 280 LYS n 
1 281 LEU n 
1 282 HIS n 
1 283 THR n 
1 284 SER n 
1 285 PRO n 
1 286 LEU n 
1 287 CYS n 
1 288 THR n 
1 289 THR n 
1 290 ASN n 
1 291 THR n 
1 292 LYS n 
1 293 GLU n 
1 294 GLY n 
1 295 SER n 
1 296 ASN n 
1 297 ILE n 
1 298 CYS n 
1 299 LEU n 
1 300 THR n 
1 301 ARG n 
1 302 THR n 
1 303 ASP n 
1 304 ARG n 
1 305 GLY n 
1 306 TRP n 
1 307 TYR n 
1 308 CYS n 
1 309 ASP n 
1 310 ASN n 
1 311 ALA n 
1 312 GLY n 
1 313 SER n 
1 314 VAL n 
1 315 SER n 
1 316 PHE n 
1 317 PHE n 
1 318 PRO n 
1 319 GLN n 
1 320 ALA n 
1 321 GLU n 
1 322 THR n 
1 323 CYS n 
1 324 LYS n 
1 325 VAL n 
1 326 GLN n 
1 327 SER n 
1 328 ASN n 
1 329 ARG n 
1 330 VAL n 
1 331 PHE n 
1 332 CYS n 
1 333 ASP n 
1 334 THR n 
1 335 MET n 
1 336 ASN n 
1 337 SER n 
1 338 LEU n 
1 339 THR n 
1 340 LEU n 
1 341 PRO n 
1 342 SER n 
1 343 GLU n 
1 344 VAL n 
1 345 ASN n 
1 346 LEU n 
1 347 CYS n 
1 348 ASN n 
1 349 VAL n 
1 350 ASP n 
1 351 ILE n 
1 352 PHE n 
1 353 ASN n 
1 354 PRO n 
1 355 LYS n 
1 356 TYR n 
1 357 ASP n 
1 358 CYS n 
1 359 LYS n 
1 360 ILE n 
1 361 MET n 
1 362 THR n 
1 363 SER n 
1 364 LYS n 
1 365 THR n 
1 366 ASP n 
1 367 VAL n 
1 368 SER n 
1 369 SER n 
1 370 SER n 
1 371 VAL n 
1 372 ILE n 
1 373 THR n 
1 374 SER n 
1 375 LEU n 
1 376 GLY n 
1 377 ALA n 
1 378 ILE n 
1 379 VAL n 
1 380 SER n 
1 381 CYS n 
1 382 TYR n 
1 383 GLY n 
1 384 LYS n 
1 385 THR n 
1 386 LYS n 
1 387 CYS n 
1 388 THR n 
1 389 ALA n 
1 390 SER n 
1 391 ASN n 
1 392 LYS n 
1 393 ASN n 
1 394 ARG n 
1 395 GLY n 
1 396 ILE n 
1 397 ILE n 
1 398 LYS n 
1 399 THR n 
1 400 PHE n 
1 401 SER n 
1 402 ASN n 
1 403 GLY n 
1 404 CYS n 
1 405 ASP n 
1 406 TYR n 
1 407 VAL n 
1 408 SER n 
1 409 ASN n 
1 410 LYS n 
1 411 GLY n 
1 412 VAL n 
1 413 ASP n 
1 414 THR n 
1 415 VAL n 
1 416 SER n 
1 417 VAL n 
1 418 GLY n 
1 419 ASN n 
1 420 THR n 
1 421 LEU n 
1 422 TYR n 
1 423 CYS n 
1 424 VAL n 
1 425 ASN n 
1 426 LYS n 
1 427 GLN n 
1 428 GLU n 
1 429 GLY n 
1 430 LYS n 
1 431 SER n 
1 432 LEU n 
1 433 TYR n 
1 434 VAL n 
1 435 LYS n 
1 436 GLY n 
1 437 GLU n 
1 438 PRO n 
1 439 ILE n 
1 440 ILE n 
1 441 ASN n 
1 442 PHE n 
1 443 TYR n 
1 444 ASP n 
1 445 PRO n 
1 446 LEU n 
1 447 VAL n 
1 448 PHE n 
1 449 PRO n 
1 450 SER n 
1 451 ASP n 
1 452 GLU n 
1 453 PHE n 
1 454 ASP n 
1 455 ALA n 
1 456 SER n 
1 457 ILE n 
1 458 SER n 
1 459 GLN n 
1 460 VAL n 
1 461 ASN n 
1 462 GLU n 
1 463 LYS n 
1 464 ILE n 
1 465 ASN n 
1 466 GLN n 
1 467 SER n 
1 468 LEU n 
1 469 ALA n 
1 470 PHE n 
1 471 ILE n 
1 472 ARG n 
1 473 LYS n 
1 474 SER n 
1 475 ASP n 
1 476 GLU n 
1 477 LEU n 
1 478 LEU n 
1 479 ALA n 
1 480 SER n 
1 481 GLY n 
1 482 TYR n 
1 483 ILE n 
1 484 PRO n 
1 485 GLU n 
1 486 ALA n 
1 487 PRO n 
1 488 ARG n 
1 489 ASP n 
1 490 GLY n 
1 491 GLN n 
1 492 ALA n 
1 493 TYR n 
1 494 VAL n 
1 495 ARG n 
1 496 LYS n 
1 497 ASP n 
1 498 GLY n 
1 499 GLU n 
1 500 TRP n 
1 501 VAL n 
1 502 LEU n 
1 503 LEU n 
1 504 SER n 
1 505 THR n 
1 506 PHE n 
1 507 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   507 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Human respiratory syncytial virus A2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11259 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
EDO non-polymer                  . 1,2-ETHANEDIOL                           'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -3  ?   ?   ?   F . n 
A 1 2   GLY 2   -2  ?   ?   ?   F . n 
A 1 3   ILE 3   -1  ?   ?   ?   F . n 
A 1 4   LEU 4   0   ?   ?   ?   F . n 
A 1 5   PRO 5   1   ?   ?   ?   F . n 
A 1 6   SER 6   2   ?   ?   ?   F . n 
A 1 7   PRO 7   3   ?   ?   ?   F . n 
A 1 8   GLY 8   4   ?   ?   ?   F . n 
A 1 9   MET 9   5   ?   ?   ?   F . n 
A 1 10  PRO 10  6   ?   ?   ?   F . n 
A 1 11  ALA 11  7   ?   ?   ?   F . n 
A 1 12  LEU 12  8   ?   ?   ?   F . n 
A 1 13  LEU 13  9   ?   ?   ?   F . n 
A 1 14  SER 14  10  ?   ?   ?   F . n 
A 1 15  LEU 15  11  ?   ?   ?   F . n 
A 1 16  VAL 16  12  ?   ?   ?   F . n 
A 1 17  SER 17  13  ?   ?   ?   F . n 
A 1 18  LEU 18  14  ?   ?   ?   F . n 
A 1 19  LEU 19  15  ?   ?   ?   F . n 
A 1 20  SER 20  16  ?   ?   ?   F . n 
A 1 21  VAL 21  17  ?   ?   ?   F . n 
A 1 22  LEU 22  18  ?   ?   ?   F . n 
A 1 23  LEU 23  19  ?   ?   ?   F . n 
A 1 24  MET 24  20  ?   ?   ?   F . n 
A 1 25  GLY 25  21  ?   ?   ?   F . n 
A 1 26  CYS 26  22  ?   ?   ?   F . n 
A 1 27  VAL 27  23  ?   ?   ?   F . n 
A 1 28  ALA 28  24  ?   ?   ?   F . n 
A 1 29  GLU 29  25  ?   ?   ?   F . n 
A 1 30  GLN 30  26  26  GLN GLN F . n 
A 1 31  ASN 31  27  27  ASN ASN F . n 
A 1 32  ILE 32  28  28  ILE ILE F . n 
A 1 33  THR 33  29  29  THR THR F . n 
A 1 34  GLU 34  30  30  GLU GLU F . n 
A 1 35  GLU 35  31  31  GLU GLU F . n 
A 1 36  PHE 36  32  32  PHE PHE F . n 
A 1 37  TYR 37  33  33  TYR TYR F . n 
A 1 38  GLN 38  34  34  GLN GLN F . n 
A 1 39  SER 39  35  35  SER SER F . n 
A 1 40  THR 40  36  36  THR THR F . n 
A 1 41  CYS 41  37  37  CYS CYS F . n 
A 1 42  SER 42  38  38  SER SER F . n 
A 1 43  ALA 43  39  39  ALA ALA F . n 
A 1 44  VAL 44  40  40  VAL VAL F . n 
A 1 45  SER 45  41  41  SER SER F . n 
A 1 46  LYS 46  42  42  LYS LYS F . n 
A 1 47  GLY 47  43  43  GLY GLY F . n 
A 1 48  TYR 48  44  44  TYR TYR F . n 
A 1 49  LEU 49  45  45  LEU LEU F . n 
A 1 50  SER 50  46  46  SER SER F . n 
A 1 51  ALA 51  47  47  ALA ALA F . n 
A 1 52  LEU 52  48  48  LEU LEU F . n 
A 1 53  ARG 53  49  49  ARG ARG F . n 
A 1 54  THR 54  50  50  THR THR F . n 
A 1 55  GLY 55  51  51  GLY GLY F . n 
A 1 56  TRP 56  52  52  TRP TRP F . n 
A 1 57  TYR 57  53  53  TYR TYR F . n 
A 1 58  THR 58  54  54  THR THR F . n 
A 1 59  SER 59  55  55  SER SER F . n 
A 1 60  VAL 60  56  56  VAL VAL F . n 
A 1 61  ILE 61  57  57  ILE ILE F . n 
A 1 62  THR 62  58  58  THR THR F . n 
A 1 63  ILE 63  59  59  ILE ILE F . n 
A 1 64  GLU 64  60  60  GLU GLU F . n 
A 1 65  LEU 65  61  61  LEU LEU F . n 
A 1 66  SER 66  62  62  SER SER F . n 
A 1 67  ASN 67  63  63  ASN ASN F . n 
A 1 68  ILE 68  64  64  ILE ILE F . n 
A 1 69  LYS 69  65  65  LYS LYS F . n 
A 1 70  GLU 70  66  66  GLU GLU F . n 
A 1 71  ASN 71  67  67  ASN ASN F . n 
A 1 72  LYS 72  68  68  LYS LYS F . n 
A 1 73  CYS 73  69  69  CYS CYS F . n 
A 1 74  ASN 74  70  70  ASN ASN F . n 
A 1 75  GLY 75  71  71  GLY GLY F . n 
A 1 76  THR 76  72  72  THR THR F . n 
A 1 77  ASP 77  73  73  ASP ASP F . n 
A 1 78  ALA 78  74  74  ALA ALA F . n 
A 1 79  LYS 79  75  75  LYS LYS F . n 
A 1 80  VAL 80  76  76  VAL VAL F . n 
A 1 81  LYS 81  77  77  LYS LYS F . n 
A 1 82  LEU 82  78  78  LEU LEU F . n 
A 1 83  ILE 83  79  79  ILE ILE F . n 
A 1 84  LYS 84  80  80  LYS LYS F . n 
A 1 85  GLN 85  81  81  GLN GLN F . n 
A 1 86  GLU 86  82  82  GLU GLU F . n 
A 1 87  LEU 87  83  83  LEU LEU F . n 
A 1 88  ASP 88  84  84  ASP ASP F . n 
A 1 89  LYS 89  85  85  LYS LYS F . n 
A 1 90  TYR 90  86  86  TYR TYR F . n 
A 1 91  LYS 91  87  87  LYS LYS F . n 
A 1 92  ASN 92  88  88  ASN ASN F . n 
A 1 93  ALA 93  89  89  ALA ALA F . n 
A 1 94  VAL 94  90  90  VAL VAL F . n 
A 1 95  THR 95  91  91  THR THR F . n 
A 1 96  ASP 96  92  92  ASP ASP F . n 
A 1 97  LEU 97  93  93  LEU LEU F . n 
A 1 98  GLN 98  94  94  GLN GLN F . n 
A 1 99  LEU 99  95  95  LEU LEU F . n 
A 1 100 LEU 100 96  96  LEU LEU F . n 
A 1 101 MET 101 97  97  MET MET F . n 
A 1 102 GLN 102 98  98  GLN GLN F . n 
A 1 103 SER 103 99  99  SER SER F . n 
A 1 104 THR 104 100 100 THR THR F . n 
A 1 105 PRO 105 101 101 PRO PRO F . n 
A 1 106 ALA 106 102 102 ALA ALA F . n 
A 1 107 THR 107 103 103 THR THR F . n 
A 1 108 GLY 108 143 143 GLY GLY F . n 
A 1 109 SER 109 144 144 SER SER F . n 
A 1 110 GLY 110 145 145 GLY GLY F . n 
A 1 111 SER 111 146 146 SER SER F . n 
A 1 112 ALA 112 147 147 ALA ALA F . n 
A 1 113 ILE 113 148 148 ILE ILE F . n 
A 1 114 CYS 114 149 149 CYS CYS F . n 
A 1 115 SER 115 150 150 SER SER F . n 
A 1 116 GLY 116 151 151 GLY GLY F . n 
A 1 117 VAL 117 152 152 VAL VAL F . n 
A 1 118 ALA 118 153 153 ALA ALA F . n 
A 1 119 VAL 119 154 154 VAL VAL F . n 
A 1 120 CYS 120 155 155 CYS CYS F . n 
A 1 121 LYS 121 156 156 LYS LYS F . n 
A 1 122 VAL 122 157 157 VAL VAL F . n 
A 1 123 LEU 123 158 158 LEU LEU F . n 
A 1 124 HIS 124 159 159 HIS HIS F . n 
A 1 125 LEU 125 160 160 LEU LEU F . n 
A 1 126 GLU 126 161 161 GLU GLU F . n 
A 1 127 GLY 127 162 162 GLY GLY F . n 
A 1 128 GLU 128 163 163 GLU GLU F . n 
A 1 129 VAL 129 164 164 VAL VAL F . n 
A 1 130 ASN 130 165 165 ASN ASN F . n 
A 1 131 LYS 131 166 166 LYS LYS F . n 
A 1 132 ILE 132 167 167 ILE ILE F . n 
A 1 133 LYS 133 168 168 LYS LYS F . n 
A 1 134 SER 134 169 169 SER SER F . n 
A 1 135 ALA 135 170 170 ALA ALA F . n 
A 1 136 LEU 136 171 171 LEU LEU F . n 
A 1 137 LEU 137 172 172 LEU LEU F . n 
A 1 138 SER 138 173 173 SER SER F . n 
A 1 139 THR 139 174 174 THR THR F . n 
A 1 140 ASN 140 175 175 ASN ASN F . n 
A 1 141 LYS 141 176 176 LYS LYS F . n 
A 1 142 ALA 142 177 177 ALA ALA F . n 
A 1 143 VAL 143 178 178 VAL VAL F . n 
A 1 144 VAL 144 179 179 VAL VAL F . n 
A 1 145 SER 145 180 180 SER SER F . n 
A 1 146 LEU 146 181 181 LEU LEU F . n 
A 1 147 SER 147 182 182 SER SER F . n 
A 1 148 ASN 148 183 183 ASN ASN F . n 
A 1 149 GLY 149 184 184 GLY GLY F . n 
A 1 150 VAL 150 185 185 VAL VAL F . n 
A 1 151 SER 151 186 186 SER SER F . n 
A 1 152 VAL 152 187 187 VAL VAL F . n 
A 1 153 LEU 153 188 188 LEU LEU F . n 
A 1 154 THR 154 189 189 THR THR F . n 
A 1 155 SER 155 190 190 SER SER F . n 
A 1 156 LYS 156 191 191 LYS LYS F . n 
A 1 157 VAL 157 192 192 VAL VAL F . n 
A 1 158 LEU 158 193 193 LEU LEU F . n 
A 1 159 ASP 159 194 194 ASP ASP F . n 
A 1 160 LEU 160 195 195 LEU LEU F . n 
A 1 161 LYS 161 196 196 LYS LYS F . n 
A 1 162 ASN 162 197 197 ASN ASN F . n 
A 1 163 TYR 163 198 198 TYR TYR F . n 
A 1 164 ILE 164 199 199 ILE ILE F . n 
A 1 165 ASP 165 200 200 ASP ASP F . n 
A 1 166 LYS 166 201 201 LYS LYS F . n 
A 1 167 GLN 167 202 202 GLN GLN F . n 
A 1 168 LEU 168 203 203 LEU LEU F . n 
A 1 169 LEU 169 204 204 LEU LEU F . n 
A 1 170 PRO 170 205 205 PRO PRO F . n 
A 1 171 ILE 171 206 206 ILE ILE F . n 
A 1 172 VAL 172 207 207 VAL VAL F . n 
A 1 173 ASN 173 208 208 ASN ASN F . n 
A 1 174 LYS 174 209 209 LYS LYS F . n 
A 1 175 GLN 175 210 210 GLN GLN F . n 
A 1 176 SER 176 211 211 SER SER F . n 
A 1 177 CYS 177 212 212 CYS CYS F . n 
A 1 178 SER 178 213 213 SER SER F . n 
A 1 179 ILE 179 214 214 ILE ILE F . n 
A 1 180 PRO 180 215 215 PRO PRO F . n 
A 1 181 ASN 181 216 216 ASN ASN F . n 
A 1 182 ILE 182 217 217 ILE ILE F . n 
A 1 183 GLU 183 218 218 GLU GLU F . n 
A 1 184 THR 184 219 219 THR THR F . n 
A 1 185 VAL 185 220 220 VAL VAL F . n 
A 1 186 ILE 186 221 221 ILE ILE F . n 
A 1 187 GLU 187 222 222 GLU GLU F . n 
A 1 188 PHE 188 223 223 PHE PHE F . n 
A 1 189 GLN 189 224 224 GLN GLN F . n 
A 1 190 GLN 190 225 225 GLN GLN F . n 
A 1 191 LYS 191 226 226 LYS LYS F . n 
A 1 192 ASN 192 227 227 ASN ASN F . n 
A 1 193 ASN 193 228 228 ASN ASN F . n 
A 1 194 ARG 194 229 229 ARG ARG F . n 
A 1 195 LEU 195 230 230 LEU LEU F . n 
A 1 196 LEU 196 231 231 LEU LEU F . n 
A 1 197 GLU 197 232 232 GLU GLU F . n 
A 1 198 ILE 198 233 233 ILE ILE F . n 
A 1 199 THR 199 234 234 THR THR F . n 
A 1 200 ARG 200 235 235 ARG ARG F . n 
A 1 201 GLU 201 236 236 GLU GLU F . n 
A 1 202 PHE 202 237 237 PHE PHE F . n 
A 1 203 SER 203 238 238 SER SER F . n 
A 1 204 VAL 204 239 239 VAL VAL F . n 
A 1 205 ASN 205 240 240 ASN ASN F . n 
A 1 206 ALA 206 241 241 ALA ALA F . n 
A 1 207 GLY 207 242 242 GLY GLY F . n 
A 1 208 VAL 208 243 243 VAL VAL F . n 
A 1 209 THR 209 244 244 THR THR F . n 
A 1 210 THR 210 245 245 THR THR F . n 
A 1 211 PRO 211 246 246 PRO PRO F . n 
A 1 212 VAL 212 247 247 VAL VAL F . n 
A 1 213 SER 213 248 248 SER SER F . n 
A 1 214 THR 214 249 249 THR THR F . n 
A 1 215 TYR 215 250 250 TYR TYR F . n 
A 1 216 MET 216 251 251 MET MET F . n 
A 1 217 LEU 217 252 252 LEU LEU F . n 
A 1 218 THR 218 253 253 THR THR F . n 
A 1 219 ASN 219 254 254 ASN ASN F . n 
A 1 220 SER 220 255 255 SER SER F . n 
A 1 221 GLU 221 256 256 GLU GLU F . n 
A 1 222 LEU 222 257 257 LEU LEU F . n 
A 1 223 LEU 223 258 258 LEU LEU F . n 
A 1 224 SER 224 259 259 SER SER F . n 
A 1 225 LEU 225 260 260 LEU LEU F . n 
A 1 226 ILE 226 261 261 ILE ILE F . n 
A 1 227 ASN 227 262 262 ASN ASN F . n 
A 1 228 ASP 228 263 263 ASP ASP F . n 
A 1 229 MET 229 264 264 MET MET F . n 
A 1 230 PRO 230 265 265 PRO PRO F . n 
A 1 231 ILE 231 266 266 ILE ILE F . n 
A 1 232 THR 232 267 267 THR THR F . n 
A 1 233 ASN 233 268 268 ASN ASN F . n 
A 1 234 ASP 234 269 269 ASP ASP F . n 
A 1 235 GLN 235 270 270 GLN GLN F . n 
A 1 236 LYS 236 271 271 LYS LYS F . n 
A 1 237 LYS 237 272 272 LYS LYS F . n 
A 1 238 LEU 238 273 273 LEU LEU F . n 
A 1 239 MET 239 274 274 MET MET F . n 
A 1 240 SER 240 275 275 SER SER F . n 
A 1 241 ASN 241 276 276 ASN ASN F . n 
A 1 242 ASN 242 277 277 ASN ASN F . n 
A 1 243 VAL 243 278 278 VAL VAL F . n 
A 1 244 GLN 244 279 279 GLN GLN F . n 
A 1 245 ILE 245 280 280 ILE ILE F . n 
A 1 246 VAL 246 281 281 VAL VAL F . n 
A 1 247 ARG 247 282 282 ARG ARG F . n 
A 1 248 GLN 248 283 283 GLN GLN F . n 
A 1 249 GLN 249 284 284 GLN GLN F . n 
A 1 250 SER 250 285 285 SER SER F . n 
A 1 251 TYR 251 286 286 TYR TYR F . n 
A 1 252 SER 252 287 287 SER SER F . n 
A 1 253 ILE 253 288 288 ILE ILE F . n 
A 1 254 MET 254 289 289 MET MET F . n 
A 1 255 CYS 255 290 290 CYS CYS F . n 
A 1 256 ILE 256 291 291 ILE ILE F . n 
A 1 257 ILE 257 292 292 ILE ILE F . n 
A 1 258 LYS 258 293 293 LYS LYS F . n 
A 1 259 GLU 259 294 294 GLU GLU F . n 
A 1 260 GLU 260 295 295 GLU GLU F . n 
A 1 261 VAL 261 296 296 VAL VAL F . n 
A 1 262 LEU 262 297 297 LEU LEU F . n 
A 1 263 ALA 263 298 298 ALA ALA F . n 
A 1 264 TYR 264 299 299 TYR TYR F . n 
A 1 265 VAL 265 300 300 VAL VAL F . n 
A 1 266 VAL 266 301 301 VAL VAL F . n 
A 1 267 GLN 267 302 302 GLN GLN F . n 
A 1 268 LEU 268 303 303 LEU LEU F . n 
A 1 269 PRO 269 304 304 PRO PRO F . n 
A 1 270 LEU 270 305 305 LEU LEU F . n 
A 1 271 TYR 271 306 306 TYR TYR F . n 
A 1 272 GLY 272 307 307 GLY GLY F . n 
A 1 273 VAL 273 308 308 VAL VAL F . n 
A 1 274 ILE 274 309 309 ILE ILE F . n 
A 1 275 ASP 275 310 310 ASP ASP F . n 
A 1 276 THR 276 311 311 THR THR F . n 
A 1 277 PRO 277 312 312 PRO PRO F . n 
A 1 278 CYS 278 313 313 CYS CYS F . n 
A 1 279 TRP 279 314 314 TRP TRP F . n 
A 1 280 LYS 280 315 315 LYS LYS F . n 
A 1 281 LEU 281 316 316 LEU LEU F . n 
A 1 282 HIS 282 317 317 HIS HIS F . n 
A 1 283 THR 283 318 318 THR THR F . n 
A 1 284 SER 284 319 319 SER SER F . n 
A 1 285 PRO 285 320 320 PRO PRO F . n 
A 1 286 LEU 286 321 321 LEU LEU F . n 
A 1 287 CYS 287 322 322 CYS CYS F . n 
A 1 288 THR 288 323 323 THR THR F . n 
A 1 289 THR 289 324 324 THR THR F . n 
A 1 290 ASN 290 325 325 ASN ASN F . n 
A 1 291 THR 291 326 326 THR THR F . n 
A 1 292 LYS 292 327 327 LYS LYS F . n 
A 1 293 GLU 293 328 328 GLU GLU F . n 
A 1 294 GLY 294 329 329 GLY GLY F . n 
A 1 295 SER 295 330 330 SER SER F . n 
A 1 296 ASN 296 331 331 ASN ASN F . n 
A 1 297 ILE 297 332 332 ILE ILE F . n 
A 1 298 CYS 298 333 333 CYS CYS F . n 
A 1 299 LEU 299 334 334 LEU LEU F . n 
A 1 300 THR 300 335 335 THR THR F . n 
A 1 301 ARG 301 336 336 ARG ARG F . n 
A 1 302 THR 302 337 337 THR THR F . n 
A 1 303 ASP 303 338 338 ASP ASP F . n 
A 1 304 ARG 304 339 339 ARG ARG F . n 
A 1 305 GLY 305 340 340 GLY GLY F . n 
A 1 306 TRP 306 341 341 TRP TRP F . n 
A 1 307 TYR 307 342 342 TYR TYR F . n 
A 1 308 CYS 308 343 343 CYS CYS F . n 
A 1 309 ASP 309 344 344 ASP ASP F . n 
A 1 310 ASN 310 345 345 ASN ASN F . n 
A 1 311 ALA 311 346 346 ALA ALA F . n 
A 1 312 GLY 312 347 347 GLY GLY F . n 
A 1 313 SER 313 348 348 SER SER F . n 
A 1 314 VAL 314 349 349 VAL VAL F . n 
A 1 315 SER 315 350 350 SER SER F . n 
A 1 316 PHE 316 351 351 PHE PHE F . n 
A 1 317 PHE 317 352 352 PHE PHE F . n 
A 1 318 PRO 318 353 353 PRO PRO F . n 
A 1 319 GLN 319 354 354 GLN GLN F . n 
A 1 320 ALA 320 355 355 ALA ALA F . n 
A 1 321 GLU 321 356 356 GLU GLU F . n 
A 1 322 THR 322 357 357 THR THR F . n 
A 1 323 CYS 323 358 358 CYS CYS F . n 
A 1 324 LYS 324 359 359 LYS LYS F . n 
A 1 325 VAL 325 360 360 VAL VAL F . n 
A 1 326 GLN 326 361 361 GLN GLN F . n 
A 1 327 SER 327 362 362 SER SER F . n 
A 1 328 ASN 328 363 363 ASN ASN F . n 
A 1 329 ARG 329 364 364 ARG ARG F . n 
A 1 330 VAL 330 365 365 VAL VAL F . n 
A 1 331 PHE 331 366 366 PHE PHE F . n 
A 1 332 CYS 332 367 367 CYS CYS F . n 
A 1 333 ASP 333 368 368 ASP ASP F . n 
A 1 334 THR 334 369 369 THR THR F . n 
A 1 335 MET 335 370 370 MET MET F . n 
A 1 336 ASN 336 371 371 ASN ASN F . n 
A 1 337 SER 337 372 372 SER SER F . n 
A 1 338 LEU 338 373 373 LEU LEU F . n 
A 1 339 THR 339 374 374 THR THR F . n 
A 1 340 LEU 340 375 375 LEU LEU F . n 
A 1 341 PRO 341 376 376 PRO PRO F . n 
A 1 342 SER 342 377 377 SER SER F . n 
A 1 343 GLU 343 378 378 GLU GLU F . n 
A 1 344 VAL 344 379 379 VAL VAL F . n 
A 1 345 ASN 345 380 380 ASN ASN F . n 
A 1 346 LEU 346 381 381 LEU LEU F . n 
A 1 347 CYS 347 382 382 CYS CYS F . n 
A 1 348 ASN 348 383 383 ASN ASN F . n 
A 1 349 VAL 349 384 384 VAL VAL F . n 
A 1 350 ASP 350 385 385 ASP ASP F . n 
A 1 351 ILE 351 386 386 ILE ILE F . n 
A 1 352 PHE 352 387 387 PHE PHE F . n 
A 1 353 ASN 353 388 388 ASN ASN F . n 
A 1 354 PRO 354 389 389 PRO PRO F . n 
A 1 355 LYS 355 390 390 LYS LYS F . n 
A 1 356 TYR 356 391 391 TYR TYR F . n 
A 1 357 ASP 357 392 392 ASP ASP F . n 
A 1 358 CYS 358 393 393 CYS CYS F . n 
A 1 359 LYS 359 394 394 LYS LYS F . n 
A 1 360 ILE 360 395 395 ILE ILE F . n 
A 1 361 MET 361 396 396 MET MET F . n 
A 1 362 THR 362 397 397 THR THR F . n 
A 1 363 SER 363 398 398 SER SER F . n 
A 1 364 LYS 364 399 399 LYS LYS F . n 
A 1 365 THR 365 400 400 THR THR F . n 
A 1 366 ASP 366 401 401 ASP ASP F . n 
A 1 367 VAL 367 402 402 VAL VAL F . n 
A 1 368 SER 368 403 403 SER SER F . n 
A 1 369 SER 369 404 404 SER SER F . n 
A 1 370 SER 370 405 405 SER SER F . n 
A 1 371 VAL 371 406 406 VAL VAL F . n 
A 1 372 ILE 372 407 407 ILE ILE F . n 
A 1 373 THR 373 408 408 THR THR F . n 
A 1 374 SER 374 409 409 SER SER F . n 
A 1 375 LEU 375 410 410 LEU LEU F . n 
A 1 376 GLY 376 411 411 GLY GLY F . n 
A 1 377 ALA 377 412 412 ALA ALA F . n 
A 1 378 ILE 378 413 413 ILE ILE F . n 
A 1 379 VAL 379 414 414 VAL VAL F . n 
A 1 380 SER 380 415 415 SER SER F . n 
A 1 381 CYS 381 416 416 CYS CYS F . n 
A 1 382 TYR 382 417 417 TYR TYR F . n 
A 1 383 GLY 383 418 418 GLY GLY F . n 
A 1 384 LYS 384 419 419 LYS LYS F . n 
A 1 385 THR 385 420 420 THR THR F . n 
A 1 386 LYS 386 421 421 LYS LYS F . n 
A 1 387 CYS 387 422 422 CYS CYS F . n 
A 1 388 THR 388 423 423 THR THR F . n 
A 1 389 ALA 389 424 424 ALA ALA F . n 
A 1 390 SER 390 425 425 SER SER F . n 
A 1 391 ASN 391 426 426 ASN ASN F . n 
A 1 392 LYS 392 427 427 LYS LYS F . n 
A 1 393 ASN 393 428 428 ASN ASN F . n 
A 1 394 ARG 394 429 429 ARG ARG F . n 
A 1 395 GLY 395 430 430 GLY GLY F . n 
A 1 396 ILE 396 431 431 ILE ILE F . n 
A 1 397 ILE 397 432 432 ILE ILE F . n 
A 1 398 LYS 398 433 433 LYS LYS F . n 
A 1 399 THR 399 434 434 THR THR F . n 
A 1 400 PHE 400 435 435 PHE PHE F . n 
A 1 401 SER 401 436 436 SER SER F . n 
A 1 402 ASN 402 437 437 ASN ASN F . n 
A 1 403 GLY 403 438 438 GLY GLY F . n 
A 1 404 CYS 404 439 439 CYS CYS F . n 
A 1 405 ASP 405 440 440 ASP ASP F . n 
A 1 406 TYR 406 441 441 TYR TYR F . n 
A 1 407 VAL 407 442 442 VAL VAL F . n 
A 1 408 SER 408 443 443 SER SER F . n 
A 1 409 ASN 409 444 444 ASN ASN F . n 
A 1 410 LYS 410 445 445 LYS LYS F . n 
A 1 411 GLY 411 446 446 GLY GLY F . n 
A 1 412 VAL 412 447 447 VAL VAL F . n 
A 1 413 ASP 413 448 448 ASP ASP F . n 
A 1 414 THR 414 449 449 THR THR F . n 
A 1 415 VAL 415 450 450 VAL VAL F . n 
A 1 416 SER 416 451 451 SER SER F . n 
A 1 417 VAL 417 452 452 VAL VAL F . n 
A 1 418 GLY 418 453 453 GLY GLY F . n 
A 1 419 ASN 419 454 454 ASN ASN F . n 
A 1 420 THR 420 455 455 THR THR F . n 
A 1 421 LEU 421 456 456 LEU LEU F . n 
A 1 422 TYR 422 457 457 TYR TYR F . n 
A 1 423 CYS 423 458 458 CYS CYS F . n 
A 1 424 VAL 424 459 459 VAL VAL F . n 
A 1 425 ASN 425 460 460 ASN ASN F . n 
A 1 426 LYS 426 461 461 LYS LYS F . n 
A 1 427 GLN 427 462 462 GLN GLN F . n 
A 1 428 GLU 428 463 463 GLU GLU F . n 
A 1 429 GLY 429 464 464 GLY GLY F . n 
A 1 430 LYS 430 465 465 LYS LYS F . n 
A 1 431 SER 431 466 466 SER SER F . n 
A 1 432 LEU 432 467 467 LEU LEU F . n 
A 1 433 TYR 433 468 468 TYR TYR F . n 
A 1 434 VAL 434 469 469 VAL VAL F . n 
A 1 435 LYS 435 470 470 LYS LYS F . n 
A 1 436 GLY 436 471 471 GLY GLY F . n 
A 1 437 GLU 437 472 472 GLU GLU F . n 
A 1 438 PRO 438 473 473 PRO PRO F . n 
A 1 439 ILE 439 474 474 ILE ILE F . n 
A 1 440 ILE 440 475 475 ILE ILE F . n 
A 1 441 ASN 441 476 476 ASN ASN F . n 
A 1 442 PHE 442 477 477 PHE PHE F . n 
A 1 443 TYR 443 478 478 TYR TYR F . n 
A 1 444 ASP 444 479 479 ASP ASP F . n 
A 1 445 PRO 445 480 480 PRO PRO F . n 
A 1 446 LEU 446 481 481 LEU LEU F . n 
A 1 447 VAL 447 482 482 VAL VAL F . n 
A 1 448 PHE 448 483 483 PHE PHE F . n 
A 1 449 PRO 449 484 484 PRO PRO F . n 
A 1 450 SER 450 485 485 SER SER F . n 
A 1 451 ASP 451 486 486 ASP ASP F . n 
A 1 452 GLU 452 487 487 GLU GLU F . n 
A 1 453 PHE 453 488 488 PHE PHE F . n 
A 1 454 ASP 454 489 489 ASP ASP F . n 
A 1 455 ALA 455 490 490 ALA ALA F . n 
A 1 456 SER 456 491 491 SER SER F . n 
A 1 457 ILE 457 492 492 ILE ILE F . n 
A 1 458 SER 458 493 493 SER SER F . n 
A 1 459 GLN 459 494 494 GLN GLN F . n 
A 1 460 VAL 460 495 495 VAL VAL F . n 
A 1 461 ASN 461 496 496 ASN ASN F . n 
A 1 462 GLU 462 497 497 GLU GLU F . n 
A 1 463 LYS 463 498 498 LYS LYS F . n 
A 1 464 ILE 464 499 499 ILE ILE F . n 
A 1 465 ASN 465 500 500 ASN ASN F . n 
A 1 466 GLN 466 501 501 GLN GLN F . n 
A 1 467 SER 467 502 502 SER SER F . n 
A 1 468 LEU 468 503 503 LEU LEU F . n 
A 1 469 ALA 469 504 504 ALA ALA F . n 
A 1 470 PHE 470 505 505 PHE PHE F . n 
A 1 471 ILE 471 506 506 ILE ILE F . n 
A 1 472 ARG 472 507 507 ARG ARG F . n 
A 1 473 LYS 473 508 508 LYS LYS F . n 
A 1 474 SER 474 509 509 SER SER F . n 
A 1 475 ASP 475 510 ?   ?   ?   F . n 
A 1 476 GLU 476 511 ?   ?   ?   F . n 
A 1 477 LEU 477 512 ?   ?   ?   F . n 
A 1 478 LEU 478 513 ?   ?   ?   F . n 
A 1 479 ALA 479 514 ?   ?   ?   F . n 
A 1 480 SER 480 515 ?   ?   ?   F . n 
A 1 481 GLY 481 516 ?   ?   ?   F . n 
A 1 482 TYR 482 517 ?   ?   ?   F . n 
A 1 483 ILE 483 518 ?   ?   ?   F . n 
A 1 484 PRO 484 519 ?   ?   ?   F . n 
A 1 485 GLU 485 520 ?   ?   ?   F . n 
A 1 486 ALA 486 521 ?   ?   ?   F . n 
A 1 487 PRO 487 522 ?   ?   ?   F . n 
A 1 488 ARG 488 523 ?   ?   ?   F . n 
A 1 489 ASP 489 524 ?   ?   ?   F . n 
A 1 490 GLY 490 525 ?   ?   ?   F . n 
A 1 491 GLN 491 526 ?   ?   ?   F . n 
A 1 492 ALA 492 527 ?   ?   ?   F . n 
A 1 493 TYR 493 528 ?   ?   ?   F . n 
A 1 494 VAL 494 529 ?   ?   ?   F . n 
A 1 495 ARG 495 530 ?   ?   ?   F . n 
A 1 496 LYS 496 531 ?   ?   ?   F . n 
A 1 497 ASP 497 532 ?   ?   ?   F . n 
A 1 498 GLY 498 533 ?   ?   ?   F . n 
A 1 499 GLU 499 534 ?   ?   ?   F . n 
A 1 500 TRP 500 535 ?   ?   ?   F . n 
A 1 501 VAL 501 536 ?   ?   ?   F . n 
A 1 502 LEU 502 537 ?   ?   ?   F . n 
A 1 503 LEU 503 538 ?   ?   ?   F . n 
A 1 504 SER 504 539 ?   ?   ?   F . n 
A 1 505 THR 505 540 ?   ?   ?   F . n 
A 1 506 PHE 506 541 ?   ?   ?   F . n 
A 1 507 LEU 507 542 ?   ?   ?   F . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 NAG 1   601 510 NAG NAG F . 
C 3 EDO 1   602 512 EDO EDO F . 
D 3 EDO 1   603 513 EDO EDO F . 
E 3 EDO 1   604 514 EDO EDO F . 
F 4 HOH 1   701 136 HOH HOH F . 
F 4 HOH 2   702 24  HOH HOH F . 
F 4 HOH 3   703 156 HOH HOH F . 
F 4 HOH 4   704 22  HOH HOH F . 
F 4 HOH 5   705 254 HOH HOH F . 
F 4 HOH 6   706 102 HOH HOH F . 
F 4 HOH 7   707 11  HOH HOH F . 
F 4 HOH 8   708 91  HOH HOH F . 
F 4 HOH 9   709 118 HOH HOH F . 
F 4 HOH 10  710 101 HOH HOH F . 
F 4 HOH 11  711 34  HOH HOH F . 
F 4 HOH 12  712 146 HOH HOH F . 
F 4 HOH 13  713 89  HOH HOH F . 
F 4 HOH 14  714 71  HOH HOH F . 
F 4 HOH 15  715 35  HOH HOH F . 
F 4 HOH 16  716 92  HOH HOH F . 
F 4 HOH 17  717 46  HOH HOH F . 
F 4 HOH 18  718 23  HOH HOH F . 
F 4 HOH 19  719 109 HOH HOH F . 
F 4 HOH 20  720 115 HOH HOH F . 
F 4 HOH 21  721 58  HOH HOH F . 
F 4 HOH 22  722 1   HOH HOH F . 
F 4 HOH 23  723 18  HOH HOH F . 
F 4 HOH 24  724 144 HOH HOH F . 
F 4 HOH 25  725 229 HOH HOH F . 
F 4 HOH 26  726 51  HOH HOH F . 
F 4 HOH 27  727 30  HOH HOH F . 
F 4 HOH 28  728 148 HOH HOH F . 
F 4 HOH 29  729 152 HOH HOH F . 
F 4 HOH 30  730 217 HOH HOH F . 
F 4 HOH 31  731 8   HOH HOH F . 
F 4 HOH 32  732 192 HOH HOH F . 
F 4 HOH 33  733 66  HOH HOH F . 
F 4 HOH 34  734 42  HOH HOH F . 
F 4 HOH 35  735 163 HOH HOH F . 
F 4 HOH 36  736 84  HOH HOH F . 
F 4 HOH 37  737 45  HOH HOH F . 
F 4 HOH 38  738 13  HOH HOH F . 
F 4 HOH 39  739 193 HOH HOH F . 
F 4 HOH 40  740 50  HOH HOH F . 
F 4 HOH 41  741 72  HOH HOH F . 
F 4 HOH 42  742 114 HOH HOH F . 
F 4 HOH 43  743 87  HOH HOH F . 
F 4 HOH 44  744 224 HOH HOH F . 
F 4 HOH 45  745 77  HOH HOH F . 
F 4 HOH 46  746 36  HOH HOH F . 
F 4 HOH 47  747 63  HOH HOH F . 
F 4 HOH 48  748 123 HOH HOH F . 
F 4 HOH 49  749 141 HOH HOH F . 
F 4 HOH 50  750 19  HOH HOH F . 
F 4 HOH 51  751 15  HOH HOH F . 
F 4 HOH 52  752 80  HOH HOH F . 
F 4 HOH 53  753 173 HOH HOH F . 
F 4 HOH 54  754 147 HOH HOH F . 
F 4 HOH 55  755 153 HOH HOH F . 
F 4 HOH 56  756 28  HOH HOH F . 
F 4 HOH 57  757 154 HOH HOH F . 
F 4 HOH 58  758 47  HOH HOH F . 
F 4 HOH 59  759 4   HOH HOH F . 
F 4 HOH 60  760 116 HOH HOH F . 
F 4 HOH 61  761 43  HOH HOH F . 
F 4 HOH 62  762 99  HOH HOH F . 
F 4 HOH 63  763 2   HOH HOH F . 
F 4 HOH 64  764 37  HOH HOH F . 
F 4 HOH 65  765 65  HOH HOH F . 
F 4 HOH 66  766 189 HOH HOH F . 
F 4 HOH 67  767 29  HOH HOH F . 
F 4 HOH 68  768 20  HOH HOH F . 
F 4 HOH 69  769 39  HOH HOH F . 
F 4 HOH 70  770 151 HOH HOH F . 
F 4 HOH 71  771 98  HOH HOH F . 
F 4 HOH 72  772 79  HOH HOH F . 
F 4 HOH 73  773 149 HOH HOH F . 
F 4 HOH 74  774 40  HOH HOH F . 
F 4 HOH 75  775 202 HOH HOH F . 
F 4 HOH 76  776 21  HOH HOH F . 
F 4 HOH 77  777 167 HOH HOH F . 
F 4 HOH 78  778 186 HOH HOH F . 
F 4 HOH 79  779 107 HOH HOH F . 
F 4 HOH 80  780 169 HOH HOH F . 
F 4 HOH 81  781 27  HOH HOH F . 
F 4 HOH 82  782 5   HOH HOH F . 
F 4 HOH 83  783 41  HOH HOH F . 
F 4 HOH 84  784 75  HOH HOH F . 
F 4 HOH 85  785 33  HOH HOH F . 
F 4 HOH 86  786 14  HOH HOH F . 
F 4 HOH 87  787 54  HOH HOH F . 
F 4 HOH 88  788 64  HOH HOH F . 
F 4 HOH 89  789 7   HOH HOH F . 
F 4 HOH 90  790 60  HOH HOH F . 
F 4 HOH 91  791 9   HOH HOH F . 
F 4 HOH 92  792 105 HOH HOH F . 
F 4 HOH 93  793 197 HOH HOH F . 
F 4 HOH 94  794 82  HOH HOH F . 
F 4 HOH 95  795 83  HOH HOH F . 
F 4 HOH 96  796 73  HOH HOH F . 
F 4 HOH 97  797 179 HOH HOH F . 
F 4 HOH 98  798 138 HOH HOH F . 
F 4 HOH 99  799 112 HOH HOH F . 
F 4 HOH 100 800 93  HOH HOH F . 
F 4 HOH 101 801 126 HOH HOH F . 
F 4 HOH 102 802 32  HOH HOH F . 
F 4 HOH 103 803 113 HOH HOH F . 
F 4 HOH 104 804 44  HOH HOH F . 
F 4 HOH 105 805 96  HOH HOH F . 
F 4 HOH 106 806 48  HOH HOH F . 
F 4 HOH 107 807 31  HOH HOH F . 
F 4 HOH 108 808 176 HOH HOH F . 
F 4 HOH 109 809 131 HOH HOH F . 
F 4 HOH 110 810 137 HOH HOH F . 
F 4 HOH 111 811 68  HOH HOH F . 
F 4 HOH 112 812 3   HOH HOH F . 
F 4 HOH 113 813 164 HOH HOH F . 
F 4 HOH 114 814 133 HOH HOH F . 
F 4 HOH 115 815 16  HOH HOH F . 
F 4 HOH 116 816 174 HOH HOH F . 
F 4 HOH 117 817 121 HOH HOH F . 
F 4 HOH 118 818 26  HOH HOH F . 
F 4 HOH 119 819 53  HOH HOH F . 
F 4 HOH 120 820 122 HOH HOH F . 
F 4 HOH 121 821 139 HOH HOH F . 
F 4 HOH 122 822 110 HOH HOH F . 
F 4 HOH 123 823 142 HOH HOH F . 
F 4 HOH 124 824 61  HOH HOH F . 
F 4 HOH 125 825 81  HOH HOH F . 
F 4 HOH 126 826 238 HOH HOH F . 
F 4 HOH 127 827 188 HOH HOH F . 
F 4 HOH 128 828 203 HOH HOH F . 
F 4 HOH 129 829 200 HOH HOH F . 
F 4 HOH 130 830 17  HOH HOH F . 
F 4 HOH 131 831 25  HOH HOH F . 
F 4 HOH 132 832 117 HOH HOH F . 
F 4 HOH 133 833 184 HOH HOH F . 
F 4 HOH 134 834 150 HOH HOH F . 
F 4 HOH 135 835 108 HOH HOH F . 
F 4 HOH 136 836 56  HOH HOH F . 
F 4 HOH 137 837 12  HOH HOH F . 
F 4 HOH 138 838 132 HOH HOH F . 
F 4 HOH 139 839 162 HOH HOH F . 
F 4 HOH 140 840 160 HOH HOH F . 
F 4 HOH 141 841 62  HOH HOH F . 
F 4 HOH 142 842 168 HOH HOH F . 
F 4 HOH 143 843 100 HOH HOH F . 
F 4 HOH 144 844 124 HOH HOH F . 
F 4 HOH 145 845 57  HOH HOH F . 
F 4 HOH 146 846 70  HOH HOH F . 
F 4 HOH 147 847 140 HOH HOH F . 
F 4 HOH 148 848 257 HOH HOH F . 
F 4 HOH 149 849 88  HOH HOH F . 
F 4 HOH 150 850 38  HOH HOH F . 
F 4 HOH 151 851 216 HOH HOH F . 
F 4 HOH 152 852 111 HOH HOH F . 
F 4 HOH 153 853 76  HOH HOH F . 
F 4 HOH 154 854 155 HOH HOH F . 
F 4 HOH 155 855 208 HOH HOH F . 
F 4 HOH 156 856 244 HOH HOH F . 
F 4 HOH 157 857 49  HOH HOH F . 
F 4 HOH 158 858 264 HOH HOH F . 
F 4 HOH 159 859 166 HOH HOH F . 
F 4 HOH 160 860 246 HOH HOH F . 
F 4 HOH 161 861 120 HOH HOH F . 
F 4 HOH 162 862 234 HOH HOH F . 
F 4 HOH 163 863 127 HOH HOH F . 
F 4 HOH 164 864 10  HOH HOH F . 
F 4 HOH 165 865 199 HOH HOH F . 
F 4 HOH 166 866 157 HOH HOH F . 
F 4 HOH 167 867 222 HOH HOH F . 
F 4 HOH 168 868 129 HOH HOH F . 
F 4 HOH 169 869 225 HOH HOH F . 
F 4 HOH 170 870 211 HOH HOH F . 
F 4 HOH 171 871 85  HOH HOH F . 
F 4 HOH 172 872 228 HOH HOH F . 
F 4 HOH 173 873 69  HOH HOH F . 
F 4 HOH 174 874 218 HOH HOH F . 
F 4 HOH 175 875 191 HOH HOH F . 
F 4 HOH 176 876 128 HOH HOH F . 
F 4 HOH 177 877 239 HOH HOH F . 
F 4 HOH 178 878 206 HOH HOH F . 
F 4 HOH 179 879 178 HOH HOH F . 
F 4 HOH 180 880 135 HOH HOH F . 
F 4 HOH 181 881 196 HOH HOH F . 
F 4 HOH 182 882 86  HOH HOH F . 
F 4 HOH 183 883 97  HOH HOH F . 
F 4 HOH 184 884 177 HOH HOH F . 
F 4 HOH 185 885 143 HOH HOH F . 
F 4 HOH 186 886 180 HOH HOH F . 
F 4 HOH 187 887 183 HOH HOH F . 
F 4 HOH 188 888 67  HOH HOH F . 
F 4 HOH 189 889 161 HOH HOH F . 
F 4 HOH 190 890 158 HOH HOH F . 
F 4 HOH 191 891 94  HOH HOH F . 
F 4 HOH 192 892 185 HOH HOH F . 
F 4 HOH 193 893 95  HOH HOH F . 
F 4 HOH 194 894 175 HOH HOH F . 
F 4 HOH 195 895 59  HOH HOH F . 
F 4 HOH 196 896 198 HOH HOH F . 
F 4 HOH 197 897 207 HOH HOH F . 
F 4 HOH 198 898 52  HOH HOH F . 
F 4 HOH 199 899 182 HOH HOH F . 
F 4 HOH 200 900 237 HOH HOH F . 
F 4 HOH 201 901 6   HOH HOH F . 
F 4 HOH 202 902 249 HOH HOH F . 
F 4 HOH 203 903 90  HOH HOH F . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W3H 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     167.933 
_cell.length_a_esd                 ? 
_cell.length_b                     167.933 
_cell.length_b_esd                 ? 
_cell.length_c                     167.933 
_cell.length_c_esd                 ? 
_cell.volume                       4735961.238 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W3H 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                213 
_symmetry.space_group_name_Hall            'P 4bd 2ab 3' 
_symmetry.space_group_name_H-M             'P 41 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8W3H 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.61 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          65.94 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Potassium Sodium tartrate, 16% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-11-22 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          27.36 
_reflns.entry_id                                       8W3H 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.25 
_reflns.d_resolution_low                               37.55 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38718 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.94 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                32.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          22.67 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1413 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.254 
_reflns_shell.d_res_low                                     2.335 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3809 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.999 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               37.20 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8W3H 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.25 
_refine.ls_d_res_low                             37.55 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     38716 
_refine.ls_number_reflns_R_free                  1920 
_refine.ls_number_reflns_R_work                  36796 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.99 
_refine.ls_percent_reflns_R_free                 4.96 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2096 
_refine.ls_R_factor_R_free                       0.2427 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2079 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.8321 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2503 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.25 
_refine_hist.d_res_low                        37.55 
_refine_hist.number_atoms_solvent             203 
_refine_hist.number_atoms_total               3657 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3428 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         26 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0100  ? 3510 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.5532  ? 4756 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0856  ? 578  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0168  ? 599  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.7237 ? 1308 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.25 2.31  . . 151 2586 100.00 . . . . 0.2518 . . . . . . . . . . . 0.3248 
'X-RAY DIFFRACTION' 2.31 2.37  . . 133 2570 100.00 . . . . 0.2360 . . . . . . . . . . . 0.2640 
'X-RAY DIFFRACTION' 2.37 2.44  . . 127 2574 100.00 . . . . 0.2375 . . . . . . . . . . . 0.2992 
'X-RAY DIFFRACTION' 2.44 2.52  . . 123 2592 100.00 . . . . 0.2428 . . . . . . . . . . . 0.3169 
'X-RAY DIFFRACTION' 2.52 2.61  . . 139 2572 100.00 . . . . 0.2367 . . . . . . . . . . . 0.2649 
'X-RAY DIFFRACTION' 2.61 2.72  . . 160 2567 100.00 . . . . 0.2403 . . . . . . . . . . . 0.2947 
'X-RAY DIFFRACTION' 2.72 2.84  . . 138 2606 100.00 . . . . 0.2358 . . . . . . . . . . . 0.2572 
'X-RAY DIFFRACTION' 2.84 2.99  . . 131 2594 100.00 . . . . 0.2285 . . . . . . . . . . . 0.2507 
'X-RAY DIFFRACTION' 2.99 3.18  . . 108 2646 100.00 . . . . 0.2195 . . . . . . . . . . . 0.2693 
'X-RAY DIFFRACTION' 3.18 3.42  . . 156 2612 100.00 . . . . 0.2253 . . . . . . . . . . . 0.2636 
'X-RAY DIFFRACTION' 3.42 3.77  . . 140 2634 100.00 . . . . 0.1946 . . . . . . . . . . . 0.2122 
'X-RAY DIFFRACTION' 3.77 4.31  . . 127 2671 100.00 . . . . 0.1805 . . . . . . . . . . . 0.2325 
'X-RAY DIFFRACTION' 4.31 5.43  . . 129 2715 100.00 . . . . 0.1653 . . . . . . . . . . . 0.1967 
'X-RAY DIFFRACTION' 5.43 37.55 . . 158 2857 99.87  . . . . 0.1929 . . . . . . . . . . . 0.1952 
# 
_struct.entry_id                     8W3H 
_struct.title                        'Crystal structure of prefusion-stabilized RSV F protein UFCR1-iSS' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W3H 
_struct_keywords.text            'Respiratory syncytial virus, glycoprotein, prefusion vaccine, stabilized, viral protein' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8W3H 
_struct_ref.pdbx_db_accession          8W3H 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8W3H 
_struct_ref_seq.pdbx_strand_id                F 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 507 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8W3H 
_struct_ref_seq.db_align_beg                  -3 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  542 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -3 
_struct_ref_seq.pdbx_auth_seq_align_end       542 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 12850 ? 
1 MORE         4     ? 
1 'SSA (A^2)'  55150 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000 0.0000000000 0.0000000000 0.0000000000    0.0000000000 1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000    
2 'crystal symmetry operation' 5_663 z+1,x+1,y-2 0.0000000000 0.0000000000 1.0000000000 167.9330000000  1.0000000000 0.0000000000 
0.0000000000 167.9330000000 0.0000000000 1.0000000000 0.0000000000 -335.8660000000 
3 'crystal symmetry operation' 9_474 y-1,z+2,x-1 0.0000000000 1.0000000000 0.0000000000 -167.9330000000 0.0000000000 0.0000000000 
1.0000000000 335.8660000000 1.0000000000 0.0000000000 0.0000000000 -167.9330000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 77  ? SER A 103 ? ASP F 73  SER F 99  1 ? 27 
HELX_P HELX_P2  AA2 SER A 109 ? ALA A 112 ? SER F 144 ALA F 147 5 ? 4  
HELX_P HELX_P3  AA3 ILE A 113 ? HIS A 124 ? ILE F 148 HIS F 159 1 ? 12 
HELX_P HELX_P4  AA4 GLY A 127 ? LEU A 136 ? GLY F 162 LEU F 171 1 ? 10 
HELX_P HELX_P5  AA5 LEU A 160 ? LEU A 168 ? LEU F 195 LEU F 203 1 ? 9  
HELX_P HELX_P6  AA6 LEU A 168 ? ASN A 173 ? LEU F 203 ASN F 208 1 ? 6  
HELX_P HELX_P7  AA7 ASN A 181 ? ASN A 205 ? ASN F 216 ASN F 240 1 ? 25 
HELX_P HELX_P8  AA8 THR A 218 ? ASP A 228 ? THR F 253 ASP F 263 1 ? 11 
HELX_P HELX_P9  AA9 THR A 232 ? ASN A 242 ? THR F 267 ASN F 277 1 ? 11 
HELX_P HELX_P10 AB1 ASN A 242 ? GLN A 249 ? ASN F 277 GLN F 284 1 ? 8  
HELX_P HELX_P11 AB2 GLN A 319 ? GLU A 321 ? GLN F 354 GLU F 356 5 ? 3  
HELX_P HELX_P12 AB3 MET A 335 ? SER A 337 ? MET F 370 SER F 372 5 ? 3  
HELX_P HELX_P13 AB4 PRO A 341 ? VAL A 349 ? PRO F 376 VAL F 384 5 ? 9  
HELX_P HELX_P14 AB5 PRO A 438 ? TYR A 443 ? PRO F 473 TYR F 478 5 ? 6  
HELX_P HELX_P15 AB6 ASP A 444 ? PHE A 448 ? ASP F 479 PHE F 483 5 ? 5  
HELX_P HELX_P16 AB7 ILE A 457 ? LYS A 473 ? ILE F 492 LYS F 508 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 41  SG  ? ? ? 1_555 A CYS 404 SG ? ? F CYS 37  F CYS 439 1_555 ? ? ? ? ? ? ? 1.990 ? ?               
disulf2 disulf ?   ? A CYS 73  SG  ? ? ? 1_555 A CYS 177 SG ? ? F CYS 69  F CYS 212 1_555 ? ? ? ? ? ? ? 1.989 ? ?               
disulf3 disulf ?   ? A CYS 114 SG  ? ? ? 1_555 A CYS 423 SG ? ? F CYS 149 F CYS 458 5_663 ? ? ? ? ? ? ? 2.075 ? ?               
disulf4 disulf ?   ? A CYS 120 SG  ? ? ? 1_555 A CYS 255 SG ? ? F CYS 155 F CYS 290 1_555 ? ? ? ? ? ? ? 2.054 ? ?               
disulf5 disulf ?   ? A CYS 278 SG  ? ? ? 1_555 A CYS 308 SG ? ? F CYS 313 F CYS 343 1_555 ? ? ? ? ? ? ? 2.080 ? ?               
disulf6 disulf ?   ? A CYS 287 SG  ? ? ? 1_555 A CYS 298 SG ? ? F CYS 322 F CYS 333 1_555 ? ? ? ? ? ? ? 2.028 ? ?               
disulf7 disulf ?   ? A CYS 323 SG  ? ? ? 1_555 A CYS 332 SG ? ? F CYS 358 F CYS 367 1_555 ? ? ? ? ? ? ? 2.110 ? ?               
disulf8 disulf ?   ? A CYS 347 SG  ? ? ? 1_555 A CYS 358 SG ? ? F CYS 382 F CYS 393 1_555 ? ? ? ? ? ? ? 2.076 ? ?               
disulf9 disulf ?   ? A CYS 381 SG  ? ? ? 1_555 A CYS 387 SG ? ? F CYS 416 F CYS 422 1_555 ? ? ? ? ? ? ? 2.117 ? ?               
covale1 covale one ? A ASN 465 ND2 ? ? ? 1_555 B NAG .   C1 ? ? F ASN 500 F NAG 601 1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG B .   ? ASN A 465 ? NAG F 601 ? 1_555 ASN F 500 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  CYS A 41  ? CYS A 404 ? CYS F 37  ? 1_555 CYS F 439 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3  CYS A 73  ? CYS A 177 ? CYS F 69  ? 1_555 CYS F 212 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4  CYS A 114 ? CYS A 423 ? CYS F 149 ? 1_555 CYS F 458 ? 5_663 SG SG  .   . .   None            'Disulfide bridge' 
5  CYS A 120 ? CYS A 255 ? CYS F 155 ? 1_555 CYS F 290 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6  CYS A 278 ? CYS A 308 ? CYS F 313 ? 1_555 CYS F 343 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7  CYS A 287 ? CYS A 298 ? CYS F 322 ? 1_555 CYS F 333 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS A 323 ? CYS A 332 ? CYS F 358 ? 1_555 CYS F 367 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS A 347 ? CYS A 358 ? CYS F 382 ? 1_555 CYS F 393 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS A 381 ? CYS A 387 ? CYS F 416 ? 1_555 CYS F 422 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          THR 
_struct_mon_prot_cis.label_seq_id           210 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           THR 
_struct_mon_prot_cis.auth_seq_id            245 
_struct_mon_prot_cis.auth_asym_id           F 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    211 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     246 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    F 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.49 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 13 ? 
AA2 ? 4  ? 
AA3 ? 3  ? 
AA4 ? 4  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA1 1  13 ? parallel      
AA1 2  4  ? parallel      
AA1 2  7  ? anti-parallel 
AA1 2  11 ? parallel      
AA1 3  4  ? anti-parallel 
AA1 5  6  ? anti-parallel 
AA1 6  7  ? anti-parallel 
AA1 7  8  ? anti-parallel 
AA1 8  9  ? anti-parallel 
AA1 9  12 ? anti-parallel 
AA1 10 11 ? anti-parallel 
AA2 1  2  ? anti-parallel 
AA2 2  3  ? anti-parallel 
AA2 3  4  ? anti-parallel 
AA3 1  2  ? anti-parallel 
AA3 2  3  ? anti-parallel 
AA4 1  2  ? anti-parallel 
AA4 2  3  ? anti-parallel 
AA4 3  4  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  THR A 33  ? TYR A 37  ? THR F 29  TYR F 33  
AA1 2  SER A 42  ? GLU A 64  ? SER F 38  GLU F 60  
AA1 3  LYS A 141 ? SER A 145 ? LYS F 176 SER F 180 
AA1 4  SER A 151 ? ASP A 159 ? SER F 186 ASP F 194 
AA1 5  VAL A 208 ? THR A 209 ? VAL F 243 THR F 244 
AA1 6  TYR A 251 ? ILE A 257 ? TYR F 286 ILE F 292 
AA1 7  VAL A 261 ? THR A 283 ? VAL F 296 THR F 318 
AA1 8  GLY A 305 ? ASN A 310 ? GLY F 340 ASN F 345 
AA1 9  SER A 313 ? PHE A 317 ? SER F 348 PHE F 352 
AA1 10 CYS A 323 ? VAL A 325 ? CYS F 358 VAL F 360 
AA1 11 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA1 12 LEU A 338 ? LEU A 340 ? LEU F 373 LEU F 375 
AA1 13 LYS A 430 ? VAL A 434 ? LYS F 465 VAL F 469 
AA2 1  LEU A 286 ? CYS A 287 ? LEU F 321 CYS F 322 
AA2 2  CYS A 298 ? ARG A 301 ? CYS F 333 ARG F 336 
AA2 3  LYS A 359 ? MET A 361 ? LYS F 394 MET F 396 
AA2 4  ALA A 455 ? SER A 456 ? ALA F 490 SER F 491 
AA3 1  SER A 369 ? ILE A 372 ? SER F 404 ILE F 407 
AA3 2  GLY A 376 ? CYS A 381 ? GLY F 411 CYS F 416 
AA3 3  GLY A 403 ? SER A 408 ? GLY F 438 SER F 443 
AA4 1  GLY A 395 ? THR A 399 ? GLY F 430 THR F 434 
AA4 2  CYS A 387 ? ASN A 391 ? CYS F 422 ASN F 426 
AA4 3  THR A 414 ? VAL A 417 ? THR F 449 VAL F 452 
AA4 4  THR A 420 ? CYS A 423 ? THR F 455 CYS F 458 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N TYR A 37  ? N TYR F 33  O SER A 42  ? O SER F 38  
AA1 1  13 N PHE A 36  ? N PHE F 32  O VAL A 434 ? O VAL F 469 
AA1 2  4  N THR A 62  ? N THR F 58  O SER A 155 ? O SER F 190 
AA1 2  7  N ILE A 61  ? N ILE F 57  O TYR A 264 ? O TYR F 299 
AA1 2  11 N ARG A 53  ? N ARG F 49  O CYS A 332 ? O CYS F 367 
AA1 3  4  N ALA A 142 ? N ALA F 177 O THR A 154 ? O THR F 189 
AA1 5  6  N THR A 209 ? N THR F 244 O SER A 252 ? O SER F 287 
AA1 6  7  N ILE A 253 ? N ILE F 288 O VAL A 265 ? O VAL F 300 
AA1 7  8  N PRO A 277 ? N PRO F 312 O ASP A 309 ? O ASP F 344 
AA1 8  9  N CYS A 308 ? N CYS F 343 O SER A 315 ? O SER F 350 
AA1 9  12 N VAL A 314 ? N VAL F 349 O LEU A 340 ? O LEU F 375 
AA1 10 11 N LYS A 324 ? N LYS F 359 O PHE A 331 ? O PHE F 366 
AA2 1  2  N LEU A 286 ? N LEU F 321 O LEU A 299 ? O LEU F 334 
AA2 2  3  N THR A 300 ? N THR F 335 O MET A 361 ? O MET F 396 
AA2 3  4  N ILE A 360 ? N ILE F 395 O ALA A 455 ? O ALA F 490 
AA3 1  2  N SER A 369 ? N SER F 404 O SER A 380 ? O SER F 415 
AA3 2  3  N VAL A 379 ? N VAL F 414 O ASP A 405 ? O ASP F 440 
AA4 1  2  O ILE A 397 ? O ILE F 432 N ALA A 389 ? N ALA F 424 
AA4 2  3  N THR A 388 ? N THR F 423 O SER A 416 ? O SER F 451 
AA4 3  4  N VAL A 415 ? N VAL F 450 O TYR A 422 ? O TYR F 457 
# 
_pdbx_entry_details.entry_id                   8W3H 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR F 72  ? ? -141.88 -10.16  
2 1 LEU F 171 ? ? -92.31  34.19   
3 1 ASN F 208 ? ? -108.16 60.94   
4 1 LYS F 209 ? ? -175.56 -172.75 
5 1 CYS F 290 ? ? -95.15  -100.78 
6 1 GLN F 361 ? ? -122.88 -102.20 
7 1 ASP F 486 ? ? 70.54   36.69   
8 1 ASP F 489 ? ? -114.69 61.90   
9 1 ALA F 490 ? ? -100.21 -165.20 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  x+1/4,-z+1/4,y+3/4   
3  x+3/4,z+1/4,-y+1/4   
4  z+3/4,y+1/4,-x+1/4   
5  -z+1/4,y+3/4,x+1/4   
6  -y+1/4,x+3/4,z+1/4   
7  y+1/4,-x+1/4,z+3/4   
8  z,x,y                
9  y,z,x                
10 -y+1/2,-z,x+1/2      
11 z+1/2,-x+1/2,-y      
12 -y,z+1/2,-x+1/2      
13 -z+1/2,-x,y+1/2      
14 -z,x+1/2,-y+1/2      
15 y+1/2,-z+1/2,-x      
16 x+1/2,-y+1/2,-z      
17 -x,y+1/2,-z+1/2      
18 -x+1/2,-y,z+1/2      
19 y+3/4,x+1/4,-z+1/4   
20 -y+3/4,-x+3/4,-z+3/4 
21 z+1/4,-y+1/4,x+3/4   
22 -z+3/4,-y+3/4,-x+3/4 
23 -x+1/4,z+3/4,y+1/4   
24 -x+3/4,-z+3/4,-y+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 F MET -3  ? A MET 1   
2  1 Y 1 F GLY -2  ? A GLY 2   
3  1 Y 1 F ILE -1  ? A ILE 3   
4  1 Y 1 F LEU 0   ? A LEU 4   
5  1 Y 1 F PRO 1   ? A PRO 5   
6  1 Y 1 F SER 2   ? A SER 6   
7  1 Y 1 F PRO 3   ? A PRO 7   
8  1 Y 1 F GLY 4   ? A GLY 8   
9  1 Y 1 F MET 5   ? A MET 9   
10 1 Y 1 F PRO 6   ? A PRO 10  
11 1 Y 1 F ALA 7   ? A ALA 11  
12 1 Y 1 F LEU 8   ? A LEU 12  
13 1 Y 1 F LEU 9   ? A LEU 13  
14 1 Y 1 F SER 10  ? A SER 14  
15 1 Y 1 F LEU 11  ? A LEU 15  
16 1 Y 1 F VAL 12  ? A VAL 16  
17 1 Y 1 F SER 13  ? A SER 17  
18 1 Y 1 F LEU 14  ? A LEU 18  
19 1 Y 1 F LEU 15  ? A LEU 19  
20 1 Y 1 F SER 16  ? A SER 20  
21 1 Y 1 F VAL 17  ? A VAL 21  
22 1 Y 1 F LEU 18  ? A LEU 22  
23 1 Y 1 F LEU 19  ? A LEU 23  
24 1 Y 1 F MET 20  ? A MET 24  
25 1 Y 1 F GLY 21  ? A GLY 25  
26 1 Y 1 F CYS 22  ? A CYS 26  
27 1 Y 1 F VAL 23  ? A VAL 27  
28 1 Y 1 F ALA 24  ? A ALA 28  
29 1 Y 1 F GLU 25  ? A GLU 29  
30 1 Y 1 F ASP 510 ? A ASP 475 
31 1 Y 1 F GLU 511 ? A GLU 476 
32 1 Y 1 F LEU 512 ? A LEU 477 
33 1 Y 1 F LEU 513 ? A LEU 478 
34 1 Y 1 F ALA 514 ? A ALA 479 
35 1 Y 1 F SER 515 ? A SER 480 
36 1 Y 1 F GLY 516 ? A GLY 481 
37 1 Y 1 F TYR 517 ? A TYR 482 
38 1 Y 1 F ILE 518 ? A ILE 483 
39 1 Y 1 F PRO 519 ? A PRO 484 
40 1 Y 1 F GLU 520 ? A GLU 485 
41 1 Y 1 F ALA 521 ? A ALA 486 
42 1 Y 1 F PRO 522 ? A PRO 487 
43 1 Y 1 F ARG 523 ? A ARG 488 
44 1 Y 1 F ASP 524 ? A ASP 489 
45 1 Y 1 F GLY 525 ? A GLY 490 
46 1 Y 1 F GLN 526 ? A GLN 491 
47 1 Y 1 F ALA 527 ? A ALA 492 
48 1 Y 1 F TYR 528 ? A TYR 493 
49 1 Y 1 F VAL 529 ? A VAL 494 
50 1 Y 1 F ARG 530 ? A ARG 495 
51 1 Y 1 F LYS 531 ? A LYS 496 
52 1 Y 1 F ASP 532 ? A ASP 497 
53 1 Y 1 F GLY 533 ? A GLY 498 
54 1 Y 1 F GLU 534 ? A GLU 499 
55 1 Y 1 F TRP 535 ? A TRP 500 
56 1 Y 1 F VAL 536 ? A VAL 501 
57 1 Y 1 F LEU 537 ? A LEU 502 
58 1 Y 1 F LEU 538 ? A LEU 503 
59 1 Y 1 F SER 539 ? A SER 504 
60 1 Y 1 F THR 540 ? A THR 505 
61 1 Y 1 F PHE 541 ? A PHE 506 
62 1 Y 1 F LEU 542 ? A LEU 507 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EDO C1   C N N 88  
EDO O1   O N N 89  
EDO C2   C N N 90  
EDO O2   O N N 91  
EDO H11  H N N 92  
EDO H12  H N N 93  
EDO HO1  H N N 94  
EDO H21  H N N 95  
EDO H22  H N N 96  
EDO HO2  H N N 97  
GLN N    N N N 98  
GLN CA   C N S 99  
GLN C    C N N 100 
GLN O    O N N 101 
GLN CB   C N N 102 
GLN CG   C N N 103 
GLN CD   C N N 104 
GLN OE1  O N N 105 
GLN NE2  N N N 106 
GLN OXT  O N N 107 
GLN H    H N N 108 
GLN H2   H N N 109 
GLN HA   H N N 110 
GLN HB2  H N N 111 
GLN HB3  H N N 112 
GLN HG2  H N N 113 
GLN HG3  H N N 114 
GLN HE21 H N N 115 
GLN HE22 H N N 116 
GLN HXT  H N N 117 
GLU N    N N N 118 
GLU CA   C N S 119 
GLU C    C N N 120 
GLU O    O N N 121 
GLU CB   C N N 122 
GLU CG   C N N 123 
GLU CD   C N N 124 
GLU OE1  O N N 125 
GLU OE2  O N N 126 
GLU OXT  O N N 127 
GLU H    H N N 128 
GLU H2   H N N 129 
GLU HA   H N N 130 
GLU HB2  H N N 131 
GLU HB3  H N N 132 
GLU HG2  H N N 133 
GLU HG3  H N N 134 
GLU HE2  H N N 135 
GLU HXT  H N N 136 
GLY N    N N N 137 
GLY CA   C N N 138 
GLY C    C N N 139 
GLY O    O N N 140 
GLY OXT  O N N 141 
GLY H    H N N 142 
GLY H2   H N N 143 
GLY HA2  H N N 144 
GLY HA3  H N N 145 
GLY HXT  H N N 146 
HIS N    N N N 147 
HIS CA   C N S 148 
HIS C    C N N 149 
HIS O    O N N 150 
HIS CB   C N N 151 
HIS CG   C Y N 152 
HIS ND1  N Y N 153 
HIS CD2  C Y N 154 
HIS CE1  C Y N 155 
HIS NE2  N Y N 156 
HIS OXT  O N N 157 
HIS H    H N N 158 
HIS H2   H N N 159 
HIS HA   H N N 160 
HIS HB2  H N N 161 
HIS HB3  H N N 162 
HIS HD1  H N N 163 
HIS HD2  H N N 164 
HIS HE1  H N N 165 
HIS HE2  H N N 166 
HIS HXT  H N N 167 
HOH O    O N N 168 
HOH H1   H N N 169 
HOH H2   H N N 170 
ILE N    N N N 171 
ILE CA   C N S 172 
ILE C    C N N 173 
ILE O    O N N 174 
ILE CB   C N S 175 
ILE CG1  C N N 176 
ILE CG2  C N N 177 
ILE CD1  C N N 178 
ILE OXT  O N N 179 
ILE H    H N N 180 
ILE H2   H N N 181 
ILE HA   H N N 182 
ILE HB   H N N 183 
ILE HG12 H N N 184 
ILE HG13 H N N 185 
ILE HG21 H N N 186 
ILE HG22 H N N 187 
ILE HG23 H N N 188 
ILE HD11 H N N 189 
ILE HD12 H N N 190 
ILE HD13 H N N 191 
ILE HXT  H N N 192 
LEU N    N N N 193 
LEU CA   C N S 194 
LEU C    C N N 195 
LEU O    O N N 196 
LEU CB   C N N 197 
LEU CG   C N N 198 
LEU CD1  C N N 199 
LEU CD2  C N N 200 
LEU OXT  O N N 201 
LEU H    H N N 202 
LEU H2   H N N 203 
LEU HA   H N N 204 
LEU HB2  H N N 205 
LEU HB3  H N N 206 
LEU HG   H N N 207 
LEU HD11 H N N 208 
LEU HD12 H N N 209 
LEU HD13 H N N 210 
LEU HD21 H N N 211 
LEU HD22 H N N 212 
LEU HD23 H N N 213 
LEU HXT  H N N 214 
LYS N    N N N 215 
LYS CA   C N S 216 
LYS C    C N N 217 
LYS O    O N N 218 
LYS CB   C N N 219 
LYS CG   C N N 220 
LYS CD   C N N 221 
LYS CE   C N N 222 
LYS NZ   N N N 223 
LYS OXT  O N N 224 
LYS H    H N N 225 
LYS H2   H N N 226 
LYS HA   H N N 227 
LYS HB2  H N N 228 
LYS HB3  H N N 229 
LYS HG2  H N N 230 
LYS HG3  H N N 231 
LYS HD2  H N N 232 
LYS HD3  H N N 233 
LYS HE2  H N N 234 
LYS HE3  H N N 235 
LYS HZ1  H N N 236 
LYS HZ2  H N N 237 
LYS HZ3  H N N 238 
LYS HXT  H N N 239 
MET N    N N N 240 
MET CA   C N S 241 
MET C    C N N 242 
MET O    O N N 243 
MET CB   C N N 244 
MET CG   C N N 245 
MET SD   S N N 246 
MET CE   C N N 247 
MET OXT  O N N 248 
MET H    H N N 249 
MET H2   H N N 250 
MET HA   H N N 251 
MET HB2  H N N 252 
MET HB3  H N N 253 
MET HG2  H N N 254 
MET HG3  H N N 255 
MET HE1  H N N 256 
MET HE2  H N N 257 
MET HE3  H N N 258 
MET HXT  H N N 259 
NAG C1   C N R 260 
NAG C2   C N R 261 
NAG C3   C N R 262 
NAG C4   C N S 263 
NAG C5   C N R 264 
NAG C6   C N N 265 
NAG C7   C N N 266 
NAG C8   C N N 267 
NAG N2   N N N 268 
NAG O1   O N N 269 
NAG O3   O N N 270 
NAG O4   O N N 271 
NAG O5   O N N 272 
NAG O6   O N N 273 
NAG O7   O N N 274 
NAG H1   H N N 275 
NAG H2   H N N 276 
NAG H3   H N N 277 
NAG H4   H N N 278 
NAG H5   H N N 279 
NAG H61  H N N 280 
NAG H62  H N N 281 
NAG H81  H N N 282 
NAG H82  H N N 283 
NAG H83  H N N 284 
NAG HN2  H N N 285 
NAG HO1  H N N 286 
NAG HO3  H N N 287 
NAG HO4  H N N 288 
NAG HO6  H N N 289 
PHE N    N N N 290 
PHE CA   C N S 291 
PHE C    C N N 292 
PHE O    O N N 293 
PHE CB   C N N 294 
PHE CG   C Y N 295 
PHE CD1  C Y N 296 
PHE CD2  C Y N 297 
PHE CE1  C Y N 298 
PHE CE2  C Y N 299 
PHE CZ   C Y N 300 
PHE OXT  O N N 301 
PHE H    H N N 302 
PHE H2   H N N 303 
PHE HA   H N N 304 
PHE HB2  H N N 305 
PHE HB3  H N N 306 
PHE HD1  H N N 307 
PHE HD2  H N N 308 
PHE HE1  H N N 309 
PHE HE2  H N N 310 
PHE HZ   H N N 311 
PHE HXT  H N N 312 
PRO N    N N N 313 
PRO CA   C N S 314 
PRO C    C N N 315 
PRO O    O N N 316 
PRO CB   C N N 317 
PRO CG   C N N 318 
PRO CD   C N N 319 
PRO OXT  O N N 320 
PRO H    H N N 321 
PRO HA   H N N 322 
PRO HB2  H N N 323 
PRO HB3  H N N 324 
PRO HG2  H N N 325 
PRO HG3  H N N 326 
PRO HD2  H N N 327 
PRO HD3  H N N 328 
PRO HXT  H N N 329 
SER N    N N N 330 
SER CA   C N S 331 
SER C    C N N 332 
SER O    O N N 333 
SER CB   C N N 334 
SER OG   O N N 335 
SER OXT  O N N 336 
SER H    H N N 337 
SER H2   H N N 338 
SER HA   H N N 339 
SER HB2  H N N 340 
SER HB3  H N N 341 
SER HG   H N N 342 
SER HXT  H N N 343 
THR N    N N N 344 
THR CA   C N S 345 
THR C    C N N 346 
THR O    O N N 347 
THR CB   C N R 348 
THR OG1  O N N 349 
THR CG2  C N N 350 
THR OXT  O N N 351 
THR H    H N N 352 
THR H2   H N N 353 
THR HA   H N N 354 
THR HB   H N N 355 
THR HG1  H N N 356 
THR HG21 H N N 357 
THR HG22 H N N 358 
THR HG23 H N N 359 
THR HXT  H N N 360 
TRP N    N N N 361 
TRP CA   C N S 362 
TRP C    C N N 363 
TRP O    O N N 364 
TRP CB   C N N 365 
TRP CG   C Y N 366 
TRP CD1  C Y N 367 
TRP CD2  C Y N 368 
TRP NE1  N Y N 369 
TRP CE2  C Y N 370 
TRP CE3  C Y N 371 
TRP CZ2  C Y N 372 
TRP CZ3  C Y N 373 
TRP CH2  C Y N 374 
TRP OXT  O N N 375 
TRP H    H N N 376 
TRP H2   H N N 377 
TRP HA   H N N 378 
TRP HB2  H N N 379 
TRP HB3  H N N 380 
TRP HD1  H N N 381 
TRP HE1  H N N 382 
TRP HE3  H N N 383 
TRP HZ2  H N N 384 
TRP HZ3  H N N 385 
TRP HH2  H N N 386 
TRP HXT  H N N 387 
TYR N    N N N 388 
TYR CA   C N S 389 
TYR C    C N N 390 
TYR O    O N N 391 
TYR CB   C N N 392 
TYR CG   C Y N 393 
TYR CD1  C Y N 394 
TYR CD2  C Y N 395 
TYR CE1  C Y N 396 
TYR CE2  C Y N 397 
TYR CZ   C Y N 398 
TYR OH   O N N 399 
TYR OXT  O N N 400 
TYR H    H N N 401 
TYR H2   H N N 402 
TYR HA   H N N 403 
TYR HB2  H N N 404 
TYR HB3  H N N 405 
TYR HD1  H N N 406 
TYR HD2  H N N 407 
TYR HE1  H N N 408 
TYR HE2  H N N 409 
TYR HH   H N N 410 
TYR HXT  H N N 411 
VAL N    N N N 412 
VAL CA   C N S 413 
VAL C    C N N 414 
VAL O    O N N 415 
VAL CB   C N N 416 
VAL CG1  C N N 417 
VAL CG2  C N N 418 
VAL OXT  O N N 419 
VAL H    H N N 420 
VAL H2   H N N 421 
VAL HA   H N N 422 
VAL HB   H N N 423 
VAL HG11 H N N 424 
VAL HG12 H N N 425 
VAL HG13 H N N 426 
VAL HG21 H N N 427 
VAL HG22 H N N 428 
VAL HG23 H N N 429 
VAL HXT  H N N 430 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
NAG C1  C2   sing N N 246 
NAG C1  O1   sing N N 247 
NAG C1  O5   sing N N 248 
NAG C1  H1   sing N N 249 
NAG C2  C3   sing N N 250 
NAG C2  N2   sing N N 251 
NAG C2  H2   sing N N 252 
NAG C3  C4   sing N N 253 
NAG C3  O3   sing N N 254 
NAG C3  H3   sing N N 255 
NAG C4  C5   sing N N 256 
NAG C4  O4   sing N N 257 
NAG C4  H4   sing N N 258 
NAG C5  C6   sing N N 259 
NAG C5  O5   sing N N 260 
NAG C5  H5   sing N N 261 
NAG C6  O6   sing N N 262 
NAG C6  H61  sing N N 263 
NAG C6  H62  sing N N 264 
NAG C7  C8   sing N N 265 
NAG C7  N2   sing N N 266 
NAG C7  O7   doub N N 267 
NAG C8  H81  sing N N 268 
NAG C8  H82  sing N N 269 
NAG C8  H83  sing N N 270 
NAG N2  HN2  sing N N 271 
NAG O1  HO1  sing N N 272 
NAG O3  HO3  sing N N 273 
NAG O4  HO4  sing N N 274 
NAG O6  HO6  sing N N 275 
PHE N   CA   sing N N 276 
PHE N   H    sing N N 277 
PHE N   H2   sing N N 278 
PHE CA  C    sing N N 279 
PHE CA  CB   sing N N 280 
PHE CA  HA   sing N N 281 
PHE C   O    doub N N 282 
PHE C   OXT  sing N N 283 
PHE CB  CG   sing N N 284 
PHE CB  HB2  sing N N 285 
PHE CB  HB3  sing N N 286 
PHE CG  CD1  doub Y N 287 
PHE CG  CD2  sing Y N 288 
PHE CD1 CE1  sing Y N 289 
PHE CD1 HD1  sing N N 290 
PHE CD2 CE2  doub Y N 291 
PHE CD2 HD2  sing N N 292 
PHE CE1 CZ   doub Y N 293 
PHE CE1 HE1  sing N N 294 
PHE CE2 CZ   sing Y N 295 
PHE CE2 HE2  sing N N 296 
PHE CZ  HZ   sing N N 297 
PHE OXT HXT  sing N N 298 
PRO N   CA   sing N N 299 
PRO N   CD   sing N N 300 
PRO N   H    sing N N 301 
PRO CA  C    sing N N 302 
PRO CA  CB   sing N N 303 
PRO CA  HA   sing N N 304 
PRO C   O    doub N N 305 
PRO C   OXT  sing N N 306 
PRO CB  CG   sing N N 307 
PRO CB  HB2  sing N N 308 
PRO CB  HB3  sing N N 309 
PRO CG  CD   sing N N 310 
PRO CG  HG2  sing N N 311 
PRO CG  HG3  sing N N 312 
PRO CD  HD2  sing N N 313 
PRO CD  HD3  sing N N 314 
PRO OXT HXT  sing N N 315 
SER N   CA   sing N N 316 
SER N   H    sing N N 317 
SER N   H2   sing N N 318 
SER CA  C    sing N N 319 
SER CA  CB   sing N N 320 
SER CA  HA   sing N N 321 
SER C   O    doub N N 322 
SER C   OXT  sing N N 323 
SER CB  OG   sing N N 324 
SER CB  HB2  sing N N 325 
SER CB  HB3  sing N N 326 
SER OG  HG   sing N N 327 
SER OXT HXT  sing N N 328 
THR N   CA   sing N N 329 
THR N   H    sing N N 330 
THR N   H2   sing N N 331 
THR CA  C    sing N N 332 
THR CA  CB   sing N N 333 
THR CA  HA   sing N N 334 
THR C   O    doub N N 335 
THR C   OXT  sing N N 336 
THR CB  OG1  sing N N 337 
THR CB  CG2  sing N N 338 
THR CB  HB   sing N N 339 
THR OG1 HG1  sing N N 340 
THR CG2 HG21 sing N N 341 
THR CG2 HG22 sing N N 342 
THR CG2 HG23 sing N N 343 
THR OXT HXT  sing N N 344 
TRP N   CA   sing N N 345 
TRP N   H    sing N N 346 
TRP N   H2   sing N N 347 
TRP CA  C    sing N N 348 
TRP CA  CB   sing N N 349 
TRP CA  HA   sing N N 350 
TRP C   O    doub N N 351 
TRP C   OXT  sing N N 352 
TRP CB  CG   sing N N 353 
TRP CB  HB2  sing N N 354 
TRP CB  HB3  sing N N 355 
TRP CG  CD1  doub Y N 356 
TRP CG  CD2  sing Y N 357 
TRP CD1 NE1  sing Y N 358 
TRP CD1 HD1  sing N N 359 
TRP CD2 CE2  doub Y N 360 
TRP CD2 CE3  sing Y N 361 
TRP NE1 CE2  sing Y N 362 
TRP NE1 HE1  sing N N 363 
TRP CE2 CZ2  sing Y N 364 
TRP CE3 CZ3  doub Y N 365 
TRP CE3 HE3  sing N N 366 
TRP CZ2 CH2  doub Y N 367 
TRP CZ2 HZ2  sing N N 368 
TRP CZ3 CH2  sing Y N 369 
TRP CZ3 HZ3  sing N N 370 
TRP CH2 HH2  sing N N 371 
TRP OXT HXT  sing N N 372 
TYR N   CA   sing N N 373 
TYR N   H    sing N N 374 
TYR N   H2   sing N N 375 
TYR CA  C    sing N N 376 
TYR CA  CB   sing N N 377 
TYR CA  HA   sing N N 378 
TYR C   O    doub N N 379 
TYR C   OXT  sing N N 380 
TYR CB  CG   sing N N 381 
TYR CB  HB2  sing N N 382 
TYR CB  HB3  sing N N 383 
TYR CG  CD1  doub Y N 384 
TYR CG  CD2  sing Y N 385 
TYR CD1 CE1  sing Y N 386 
TYR CD1 HD1  sing N N 387 
TYR CD2 CE2  doub Y N 388 
TYR CD2 HD2  sing N N 389 
TYR CE1 CZ   doub Y N 390 
TYR CE1 HE1  sing N N 391 
TYR CE2 CZ   sing Y N 392 
TYR CE2 HE2  sing N N 393 
TYR CZ  OH   sing N N 394 
TYR OH  HH   sing N N 395 
TYR OXT HXT  sing N N 396 
VAL N   CA   sing N N 397 
VAL N   H    sing N N 398 
VAL N   H2   sing N N 399 
VAL CA  C    sing N N 400 
VAL CA  CB   sing N N 401 
VAL CA  HA   sing N N 402 
VAL C   O    doub N N 403 
VAL C   OXT  sing N N 404 
VAL CB  CG1  sing N N 405 
VAL CB  CG2  sing N N 406 
VAL CB  HB   sing N N 407 
VAL CG1 HG11 sing N N 408 
VAL CG1 HG12 sing N N 409 
VAL CG1 HG13 sing N N 410 
VAL CG2 HG21 sing N N 411 
VAL CG2 HG22 sing N N 412 
VAL CG2 HG23 sing N N 413 
VAL OXT HXT  sing N N 414 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5K6I 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 41 3 2' 
_space_group.name_Hall        'P 4bd 2ab 3' 
_space_group.IT_number        213 
_space_group.crystal_system   cubic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W3H 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005955 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005955 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005955 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 30  ? 158.96500 331.00000 34.16400  1.000 46.89779  ? 26  GLN F N   1 
ATOM   2    C CA  . GLN A 1 30  ? 160.09200 331.89600 34.46100  1.000 57.07013  ? 26  GLN F CA  1 
ATOM   3    C C   . GLN A 1 30  ? 159.68000 333.37400 34.64100  1.000 46.69385  ? 26  GLN F C   1 
ATOM   4    O O   . GLN A 1 30  ? 158.92500 333.91200 33.82600  1.000 41.80550  ? 26  GLN F O   1 
ATOM   5    C CB  . GLN A 1 30  ? 161.14600 331.79500 33.35700  1.000 59.58787  ? 26  GLN F CB  1 
ATOM   6    C CG  . GLN A 1 30  ? 162.56600 332.02400 33.83200  1.000 48.69485  ? 26  GLN F CG  1 
ATOM   7    C CD  . GLN A 1 30  ? 163.02400 330.96600 34.83100  1.000 49.64310  ? 26  GLN F CD  1 
ATOM   8    O OE1 . GLN A 1 30  ? 162.54100 329.83100 34.81300  1.000 47.12656  ? 26  GLN F OE1 1 
ATOM   9    N NE2 . GLN A 1 30  ? 163.96100 331.34100 35.71200  1.000 42.94163  ? 26  GLN F NE2 1 
ATOM   10   N N   . ASN A 1 31  ? 160.08600 333.98200 35.76400  1.000 36.25607  ? 27  ASN F N   1 
ATOM   11   C CA  . ASN A 1 31  ? 159.74800 335.36800 36.04700  1.000 35.89046  ? 27  ASN F CA  1 
ATOM   12   C C   . ASN A 1 31  ? 160.86600 336.30000 35.57700  1.000 32.21486  ? 27  ASN F C   1 
ATOM   13   O O   . ASN A 1 31  ? 161.96700 336.28300 36.14300  1.000 28.93436  ? 27  ASN F O   1 
ATOM   14   C CB  . ASN A 1 31  ? 159.55600 335.46700 37.55500  1.000 38.71308  ? 27  ASN F CB  1 
ATOM   15   C CG  . ASN A 1 31  ? 158.31400 334.71800 37.99400  1.000 53.39383  ? 27  ASN F CG  1 
ATOM   16   O OD1 . ASN A 1 31  ? 157.43900 334.43000 37.16300  1.000 46.82856  ? 27  ASN F OD1 1 
ATOM   17   N ND2 . ASN A 1 31  ? 158.24200 334.36000 39.28600  1.000 62.21462  ? 27  ASN F ND2 1 
ATOM   18   N N   . ILE A 1 32  ? 160.56000 337.17400 34.63200  1.000 25.78849  ? 28  ILE F N   1 
ATOM   19   C CA  . ILE A 1 32  ? 161.49500 338.18000 34.12500  1.000 22.91889  ? 28  ILE F CA  1 
ATOM   20   C C   . ILE A 1 32  ? 161.46700 339.39600 35.04400  1.000 24.33276  ? 28  ILE F C   1 
ATOM   21   O O   . ILE A 1 32  ? 160.38200 339.84600 35.43400  1.000 22.33346  ? 28  ILE F O   1 
ATOM   22   C CB  . ILE A 1 32  ? 161.17600 338.57500 32.67400  1.000 29.40539  ? 28  ILE F CB  1 
ATOM   23   C CG1 . ILE A 1 32  ? 161.25800 337.36100 31.74900  1.000 27.70302  ? 28  ILE F CG1 1 
ATOM   24   C CG2 . ILE A 1 32  ? 162.22600 339.63200 32.15900  1.000 18.59172  ? 28  ILE F CG2 1 
ATOM   25   C CD1 . ILE A 1 32  ? 162.47900 336.48800 32.00400  1.000 28.82166  ? 28  ILE F CD1 1 
ATOM   26   N N   . THR A 1 33  ? 162.62100 339.84300 35.52200  1.000 19.96466  ? 29  THR F N   1 
ATOM   27   C CA  . THR A 1 33  ? 162.60400 341.04000 36.35200  1.000 21.26806  ? 29  THR F CA  1 
ATOM   28   C C   . THR A 1 33  ? 163.63400 342.00300 35.77100  1.000 21.28443  ? 29  THR F C   1 
ATOM   29   O O   . THR A 1 33  ? 164.45100 341.62900 34.93500  1.000 21.43870  ? 29  THR F O   1 
ATOM   30   C CB  . THR A 1 33  ? 162.93100 340.76000 37.80500  1.000 24.51271  ? 29  THR F CB  1 
ATOM   31   O OG1 . THR A 1 33  ? 164.20400 340.13200 37.85800  1.000 22.44756  ? 29  THR F OG1 1 
ATOM   32   C CG2 . THR A 1 33  ? 161.87100 339.82200 38.42400  1.000 22.97848  ? 29  THR F CG2 1 
ATOM   33   N N   . GLU A 1 34  ? 163.54700 343.26500 36.15500  1.000 21.04678  ? 30  GLU F N   1 
ATOM   34   C CA  . GLU A 1 34  ? 164.47000 344.27600 35.65200  1.000 20.63924  ? 30  GLU F CA  1 
ATOM   35   C C   . GLU A 1 34  ? 164.84800 345.20100 36.78800  1.000 18.77818  ? 30  GLU F C   1 
ATOM   36   O O   . GLU A 1 34  ? 164.00400 345.53900 37.61300  1.000 27.04635  ? 30  GLU F O   1 
ATOM   37   C CB  . GLU A 1 34  ? 163.85200 345.03400 34.47100  1.000 18.73944  ? 30  GLU F CB  1 
ATOM   38   C CG  . GLU A 1 34  ? 164.79700 345.94200 33.70300  1.000 16.44051  ? 30  GLU F CG  1 
ATOM   39   C CD  . GLU A 1 34  ? 164.23000 346.26400 32.33100  1.000 20.09030  ? 30  GLU F CD  1 
ATOM   40   O OE1 . GLU A 1 34  ? 164.35400 345.41600 31.42200  1.000 21.62559  ? 30  GLU F OE1 1 
ATOM   41   O OE2 . GLU A 1 34  ? 163.63800 347.35200 32.15300  1.000 19.48679  ? 30  GLU F OE2 1 
ATOM   42   N N   . GLU A 1 35  ? 166.02500 345.79600 36.68000  1.000 20.50944  ? 31  GLU F N   1 
ATOM   43   C CA  . GLU A 1 35  ? 166.54200 346.73900 37.67600  1.000 21.79705  ? 31  GLU F CA  1 
ATOM   44   C C   . GLU A 1 35  ? 167.21800 347.90200 36.98300  1.000 20.82942  ? 31  GLU F C   1 
ATOM   45   O O   . GLU A 1 35  ? 168.04600 347.67000 36.10400  1.000 18.73697  ? 31  GLU F O   1 
ATOM   46   C CB  . GLU A 1 35  ? 167.55300 346.08100 38.61600  1.000 23.00166  ? 31  GLU F CB  1 
ATOM   47   C CG  . GLU A 1 35  ? 166.95000 345.12400 39.66500  1.000 26.30408  ? 31  GLU F CG  1 
ATOM   48   C CD  . GLU A 1 35  ? 168.02200 344.40100 40.47100  1.000 32.35091  ? 31  GLU F CD  1 
ATOM   49   O OE1 . GLU A 1 35  ? 169.19000 344.85800 40.49000  1.000 36.35583  ? 31  GLU F OE1 1 
ATOM   50   O OE2 . GLU A 1 35  ? 167.70000 343.35600 41.07300  1.000 49.68929  ? 31  GLU F OE2 1 
ATOM   51   N N   . PHE A 1 36  ? 166.69400 349.11100 37.18200  1.000 16.25952  ? 32  PHE F N   1 
ATOM   52   C CA  . PHE A 1 36  ? 167.32800 350.32200 36.66800  1.000 16.48361  ? 32  PHE F CA  1 
ATOM   53   C C   . PHE A 1 36  ? 168.20000 350.97300 37.73300  1.000 18.16077  ? 32  PHE F C   1 
ATOM   54   O O   . PHE A 1 36  ? 167.73200 351.21900 38.84400  1.000 21.75866  ? 32  PHE F O   1 
ATOM   55   C CB  . PHE A 1 36  ? 166.29200 351.33100 36.19000  1.000 16.97893  ? 32  PHE F CB  1 
ATOM   56   C CG  . PHE A 1 36  ? 166.87400 352.65700 35.86600  1.000 15.80109  ? 32  PHE F CG  1 
ATOM   57   C CD1 . PHE A 1 36  ? 167.58300 352.85800 34.68400  1.000 13.53960  ? 32  PHE F CD1 1 
ATOM   58   C CD2 . PHE A 1 36  ? 166.63800 353.73400 36.70000  1.000 16.64888  ? 32  PHE F CD2 1 
ATOM   59   C CE1 . PHE A 1 36  ? 168.09700 354.10200 34.37000  1.000 15.85306  ? 32  PHE F CE1 1 
ATOM   60   C CE2 . PHE A 1 36  ? 167.13000 355.00500 36.37700  1.000 18.10967  ? 32  PHE F CE2 1 
ATOM   61   C CZ  . PHE A 1 36  ? 167.86500 355.18400 35.21000  1.000 18.09641  ? 32  PHE F CZ  1 
ATOM   62   N N   . TYR A 1 37  ? 169.44900 351.31800 37.38400  1.000 15.99183  ? 33  TYR F N   1 
ATOM   63   C CA  . TYR A 1 37  ? 170.35100 351.90800 38.35900  1.000 18.39343  ? 33  TYR F CA  1 
ATOM   64   C C   . TYR A 1 37  ? 170.42500 353.38300 37.99200  1.000 19.56812  ? 33  TYR F C   1 
ATOM   65   O O   . TYR A 1 37  ? 171.08500 353.75900 37.02000  1.000 17.71394  ? 33  TYR F O   1 
ATOM   66   C CB  . TYR A 1 37  ? 171.72800 351.24000 38.34700  1.000 18.08385  ? 33  TYR F CB  1 
ATOM   67   C CG  . TYR A 1 37  ? 171.52200 349.76100 38.47100  1.000 21.25353  ? 33  TYR F CG  1 
ATOM   68   C CD1 . TYR A 1 37  ? 171.21700 349.18200 39.68300  1.000 22.46548  ? 33  TYR F CD1 1 
ATOM   69   C CD2 . TYR A 1 37  ? 171.86700 348.92400 37.41200  1.000 19.98639  ? 33  TYR F CD2 1 
ATOM   70   C CE1 . TYR A 1 37  ? 171.03100 347.82700 39.79900  1.000 21.83172  ? 33  TYR F CE1 1 
ATOM   71   C CE2 . TYR A 1 37  ? 171.73800 347.56400 37.51800  1.000 25.07142  ? 33  TYR F CE2 1 
ATOM   72   C CZ  . TYR A 1 37  ? 171.32000 347.01200 38.71900  1.000 24.78663  ? 33  TYR F CZ  1 
ATOM   73   O OH  . TYR A 1 37  ? 171.15400 345.65600 38.81600  1.000 32.87087  ? 33  TYR F OH  1 
ATOM   74   N N   . GLN A 1 38  ? 169.73800 354.21900 38.77200  1.000 16.96199  ? 34  GLN F N   1 
ATOM   75   C CA  . GLN A 1 38  ? 169.76000 355.64800 38.49800  1.000 15.14585  ? 34  GLN F CA  1 
ATOM   76   C C   . GLN A 1 38  ? 171.15600 356.21900 38.60300  1.000 19.16046  ? 34  GLN F C   1 
ATOM   77   O O   . GLN A 1 38  ? 171.49100 357.17300 37.88800  1.000 19.92647  ? 34  GLN F O   1 
ATOM   78   C CB  . GLN A 1 38  ? 168.82600 356.39100 39.44600  1.000 16.56059  ? 34  GLN F CB  1 
ATOM   79   C CG  . GLN A 1 38  ? 168.84200 357.93400 39.26300  1.000 20.43495  ? 34  GLN F CG  1 
ATOM   80   C CD  . GLN A 1 38  ? 167.94800 358.63900 40.31700  1.000 24.39702  ? 34  GLN F CD  1 
ATOM   81   O OE1 . GLN A 1 38  ? 167.73400 358.12300 41.40700  1.000 24.53393  ? 34  GLN F OE1 1 
ATOM   82   N NE2 . GLN A 1 38  ? 167.40100 359.78900 39.95900  1.000 22.63914  ? 34  GLN F NE2 1 
ATOM   83   N N   . SER A 1 39  ? 172.01000 355.60500 39.41900  1.000 15.03412  ? 35  SER F N   1 
ATOM   84   C CA  . SER A 1 39  ? 173.35200 356.15000 39.62600  1.000 19.92979  ? 35  SER F CA  1 
ATOM   85   C C   . SER A 1 39  ? 174.23900 356.01000 38.38800  1.000 15.88976  ? 35  SER F C   1 
ATOM   86   O O   . SER A 1 39  ? 175.17000 356.79700 38.21400  1.000 15.83909  ? 35  SER F O   1 
ATOM   87   C CB  . SER A 1 39  ? 174.00400 355.48200 40.84100  1.000 19.94578  ? 35  SER F CB  1 
ATOM   88   O OG  . SER A 1 39  ? 174.10700 354.08300 40.62500  1.000 23.66239  ? 35  SER F OG  1 
ATOM   89   N N   . THR A 1 40  ? 174.04800 354.97400 37.57800  1.000 15.75587  ? 36  THR F N   1 
ATOM   90   C CA  . THR A 1 40  ? 174.93100 354.74000 36.43600  1.000 15.15449  ? 36  THR F CA  1 
ATOM   91   C C   . THR A 1 40  ? 174.22000 354.77200 35.08800  1.000 16.33680  ? 36  THR F C   1 
ATOM   92   O O   . THR A 1 40  ? 174.80800 354.30500 34.10100  1.000 15.79927  ? 36  THR F O   1 
ATOM   93   C CB  . THR A 1 40  ? 175.66100 353.40500 36.57700  1.000 13.21195  ? 36  THR F CB  1 
ATOM   94   O OG1 . THR A 1 40  ? 174.71300 352.34800 36.74100  1.000 14.01081  ? 36  THR F OG1 1 
ATOM   95   C CG2 . THR A 1 40  ? 176.44200 353.48200 37.87500  1.000 12.86876  ? 36  THR F CG2 1 
ATOM   96   N N   . CYS A 1 41  ? 172.92200 355.09100 35.04700  1.000 14.23335  ? 37  CYS F N   1 
ATOM   97   C CA  . CYS A 1 41  ? 172.16500 355.14300 33.79200  1.000 14.73385  ? 37  CYS F CA  1 
ATOM   98   C C   . CYS A 1 41  ? 172.24400 353.81500 33.03100  1.000 15.47581  ? 37  CYS F C   1 
ATOM   99   O O   . CYS A 1 41  ? 172.64600 353.77100 31.86400  1.000 14.76061  ? 37  CYS F O   1 
ATOM   100  C CB  . CYS A 1 41  ? 172.65100 356.28900 32.89500  1.000 15.25945  ? 37  CYS F CB  1 
ATOM   101  S SG  . CYS A 1 41  ? 171.54200 356.62200 31.50300  1.000 20.41181  ? 37  CYS F SG  1 
ATOM   102  N N   . SER A 1 42  ? 171.97700 352.71000 33.74100  1.000 13.98945  ? 38  SER F N   1 
ATOM   103  C CA  . SER A 1 42  ? 172.06300 351.36600 33.16800  1.000 13.96098  ? 38  SER F CA  1 
ATOM   104  C C   . SER A 1 42  ? 170.96700 350.52600 33.79300  1.000 19.96115  ? 38  SER F C   1 
ATOM   105  O O   . SER A 1 42  ? 170.37000 350.93200 34.78000  1.000 16.13979  ? 38  SER F O   1 
ATOM   106  C CB  . SER A 1 42  ? 173.41600 350.68700 33.40100  1.000 13.46935  ? 38  SER F CB  1 
ATOM   107  O OG  . SER A 1 42  ? 173.76000 350.74400 34.76300  1.000 19.14102  ? 38  SER F OG  1 
ATOM   108  N N   . ALA A 1 43  ? 170.56300 349.47600 33.09600  1.000 14.28602  ? 39  ALA F N   1 
ATOM   109  C CA  . ALA A 1 43  ? 169.54400 348.54000 33.54600  1.000 10.32472  ? 39  ALA F CA  1 
ATOM   110  C C   . ALA A 1 43  ? 169.96700 347.09200 33.29700  1.000 16.62748  ? 39  ALA F C   1 
ATOM   111  O O   . ALA A 1 43  ? 170.66400 346.79200 32.32600  1.000 13.33921  ? 39  ALA F O   1 
ATOM   112  C CB  . ALA A 1 43  ? 168.18300 348.80500 32.89300  1.000 17.00675  ? 39  ALA F CB  1 
ATOM   113  N N   . VAL A 1 44  ? 169.51100 346.18300 34.15000  1.000 17.43183  ? 40  VAL F N   1 
ATOM   114  C CA  . VAL A 1 44  ? 169.78500 344.75100 33.99900  1.000 15.41946  ? 40  VAL F CA  1 
ATOM   115  C C   . VAL A 1 44  ? 168.45900 343.99300 33.95000  1.000 15.64707  ? 40  VAL F C   1 
ATOM   116  O O   . VAL A 1 44  ? 167.61700 344.14300 34.84100  1.000 19.10361  ? 40  VAL F O   1 
ATOM   117  C CB  . VAL A 1 44  ? 170.66800 344.17800 35.12000  1.000 19.29352  ? 40  VAL F CB  1 
ATOM   118  C CG1 . VAL A 1 44  ? 170.85900 342.70100 34.86600  1.000 17.36190  ? 40  VAL F CG1 1 
ATOM   119  C CG2 . VAL A 1 44  ? 172.07500 344.78600 35.04100  1.000 18.55118  ? 40  VAL F CG2 1 
ATOM   120  N N   . SER A 1 45  ? 168.24300 343.25200 32.85000  1.000 15.82487  ? 41  SER F N   1 
ATOM   121  C CA  . SER A 1 45  ? 167.05700 342.41900 32.65400  1.000 19.37254  ? 41  SER F CA  1 
ATOM   122  C C   . SER A 1 45  ? 167.46800 341.00100 33.07200  1.000 17.69117  ? 41  SER F C   1 
ATOM   123  O O   . SER A 1 45  ? 168.37100 340.42900 32.45500  1.000 17.82961  ? 41  SER F O   1 
ATOM   124  C CB  . SER A 1 45  ? 166.60200 342.45000 31.19500  1.000 20.00243  ? 41  SER F CB  1 
ATOM   125  O OG  . SER A 1 45  ? 166.33400 343.75800 30.75500  1.000 20.86180  ? 41  SER F OG  1 
ATOM   126  N N   . LYS A 1 46  ? 166.90200 340.49600 34.17400  1.000 19.13246  ? 42  LYS F N   1 
ATOM   127  C CA  . LYS A 1 46  ? 167.18500 339.19700 34.79500  1.000 18.72651  ? 42  LYS F CA  1 
ATOM   128  C C   . LYS A 1 46  ? 166.09300 338.14500 34.54200  1.000 22.65895  ? 42  LYS F C   1 
ATOM   129  O O   . LYS A 1 46  ? 164.93700 338.46500 34.24300  1.000 22.25783  ? 42  LYS F O   1 
ATOM   130  C CB  . LYS A 1 46  ? 167.28000 339.35900 36.31700  1.000 24.58008  ? 42  LYS F CB  1 
ATOM   131  C CG  . LYS A 1 46  ? 168.39900 340.19700 36.90400  1.000 28.52396  ? 42  LYS F CG  1 
ATOM   132  C CD  . LYS A 1 46  ? 168.11000 340.29300 38.40800  1.000 35.56192  ? 42  LYS F CD  1 
ATOM   133  C CE  . LYS A 1 46  ? 169.22700 339.75400 39.27200  1.000 56.56429  ? 42  LYS F CE  1 
ATOM   134  N NZ  . LYS A 1 46  ? 169.68900 340.75500 40.30300  1.000 58.00163  ? 42  LYS F NZ  1 
ATOM   135  N N   . GLY A 1 47  ? 166.42000 336.88700 34.88100  1.000 19.08465  ? 43  GLY F N   1 
ATOM   136  C CA  . GLY A 1 47  ? 165.45700 335.79400 34.85600  1.000 16.46781  ? 43  GLY F CA  1 
ATOM   137  C C   . GLY A 1 47  ? 165.51400 334.88700 33.65500  1.000 23.00612  ? 43  GLY F C   1 
ATOM   138  O O   . GLY A 1 47  ? 164.67200 333.98600 33.52700  1.000 22.10412  ? 43  GLY F O   1 
ATOM   139  N N   . TYR A 1 48  ? 166.44900 335.12400 32.75900  1.000 19.26345  ? 44  TYR F N   1 
ATOM   140  C CA  . TYR A 1 48  ? 166.61300 334.36300 31.54000  1.000 20.37539  ? 44  TYR F CA  1 
ATOM   141  C C   . TYR A 1 48  ? 167.43800 333.10400 31.80600  1.000 18.68265  ? 44  TYR F C   1 
ATOM   142  O O   . TYR A 1 48  ? 168.20600 333.04400 32.77700  1.000 19.66110  ? 44  TYR F O   1 
ATOM   143  C CB  . TYR A 1 48  ? 167.28500 335.23300 30.49400  1.000 20.71912  ? 44  TYR F CB  1 
ATOM   144  C CG  . TYR A 1 48  ? 166.39000 336.35700 30.06400  1.000 20.74612  ? 44  TYR F CG  1 
ATOM   145  C CD1 . TYR A 1 48  ? 165.43700 336.19400 29.07200  1.000 23.70506  ? 44  TYR F CD1 1 
ATOM   146  C CD2 . TYR A 1 48  ? 166.49500 337.59800 30.69400  1.000 18.02090  ? 44  TYR F CD2 1 
ATOM   147  C CE1 . TYR A 1 48  ? 164.61700 337.26500 28.69500  1.000 17.51059  ? 44  TYR F CE1 1 
ATOM   148  C CE2 . TYR A 1 48  ? 165.70900 338.64000 30.34000  1.000 20.01061  ? 44  TYR F CE2 1 
ATOM   149  C CZ  . TYR A 1 48  ? 164.77800 338.48200 29.34500  1.000 23.97961  ? 44  TYR F CZ  1 
ATOM   150  O OH  . TYR A 1 48  ? 164.01800 339.57600 29.03100  1.000 27.56946  ? 44  TYR F OH  1 
ATOM   151  N N   . LEU A 1 49  ? 167.09300 332.03900 31.09800  1.000 19.54630  ? 45  LEU F N   1 
ATOM   152  C CA  . LEU A 1 49  ? 167.78700 330.74700 31.11900  1.000 21.17612  ? 45  LEU F CA  1 
ATOM   153  C C   . LEU A 1 49  ? 168.66800 330.57300 29.87800  1.000 18.06612  ? 45  LEU F C   1 
ATOM   154  O O   . LEU A 1 49  ? 168.22100 330.84700 28.76700  1.000 20.43001  ? 45  LEU F O   1 
ATOM   155  C CB  . LEU A 1 49  ? 166.75600 329.61300 31.19100  1.000 16.03542  ? 45  LEU F CB  1 
ATOM   156  C CG  . LEU A 1 49  ? 165.91100 329.64200 32.47300  1.000 23.45285  ? 45  LEU F CG  1 
ATOM   157  C CD1 . LEU A 1 49  ? 164.85900 328.52500 32.47700  1.000 28.65732  ? 45  LEU F CD1 1 
ATOM   158  C CD2 . LEU A 1 49  ? 166.76400 329.57800 33.74200  1.000 26.38848  ? 45  LEU F CD2 1 
ATOM   159  N N   . SER A 1 50  ? 169.86600 329.99400 30.04000  1.000 19.18793  ? 46  SER F N   1 
ATOM   160  C CA  . SER A 1 50  ? 170.80400 329.86200 28.92100  1.000 14.42070  ? 46  SER F CA  1 
ATOM   161  C C   . SER A 1 50  ? 170.54600 328.62700 28.06600  1.000 17.23317  ? 46  SER F C   1 
ATOM   162  O O   . SER A 1 50  ? 169.98700 327.62500 28.51900  1.000 19.99137  ? 46  SER F O   1 
ATOM   163  C CB  . SER A 1 50  ? 172.25500 329.80100 29.41400  1.000 18.38137  ? 46  SER F CB  1 
ATOM   164  O OG  . SER A 1 50  ? 172.50900 328.66100 30.24800  1.000 18.91763  ? 46  SER F OG  1 
ATOM   165  N N   . ALA A 1 51  ? 170.95800 328.71800 26.80100  1.000 15.96426  ? 47  ALA F N   1 
ATOM   166  C CA  . ALA A 1 51  ? 171.30700 327.53600 26.03200  1.000 16.63716  ? 47  ALA F CA  1 
ATOM   167  C C   . ALA A 1 51  ? 172.47000 327.95200 25.13600  1.000 19.01223  ? 47  ALA F C   1 
ATOM   168  O O   . ALA A 1 51  ? 172.26900 328.54300 24.07500  1.000 22.48384  ? 47  ALA F O   1 
ATOM   169  C CB  . ALA A 1 51  ? 170.11400 327.05400 25.20700  1.000 14.94209  ? 47  ALA F CB  1 
ATOM   170  N N   . LEU A 1 52  ? 173.67500 327.66600 25.60000  1.000 17.93699  ? 48  LEU F N   1 
ATOM   171  C CA  . LEU A 1 52  ? 174.92000 328.03400 24.94400  1.000 14.50305  ? 48  LEU F CA  1 
ATOM   172  C C   . LEU A 1 52  ? 175.44700 326.83600 24.16400  1.000 18.67439  ? 48  LEU F C   1 
ATOM   173  O O   . LEU A 1 52  ? 175.57100 325.72700 24.73800  1.000 17.01891  ? 48  LEU F O   1 
ATOM   174  C CB  . LEU A 1 52  ? 175.93600 328.52900 25.96400  1.000 14.67118  ? 48  LEU F CB  1 
ATOM   175  C CG  . LEU A 1 52  ? 175.36600 329.60700 26.89200  1.000 16.42230  ? 48  LEU F CG  1 
ATOM   176  C CD1 . LEU A 1 52  ? 176.46700 330.16500 27.76800  1.000 12.89769  ? 48  LEU F CD1 1 
ATOM   177  C CD2 . LEU A 1 52  ? 174.61000 330.72700 26.11600  1.000 13.50727  ? 48  LEU F CD2 1 
ATOM   178  N N   . ARG A 1 53  ? 175.82200 327.06600 22.90700  1.000 16.99305  ? 49  ARG F N   1 
ATOM   179  C CA  . ARG A 1 53  ? 176.39500 326.01200 22.08900  1.000 19.99940  ? 49  ARG F CA  1 
ATOM   180  C C   . ARG A 1 53  ? 177.84700 325.78300 22.46200  1.000 19.02880  ? 49  ARG F C   1 
ATOM   181  O O   . ARG A 1 53  ? 178.66700 326.70100 22.37400  1.000 20.90617  ? 49  ARG F O   1 
ATOM   182  C CB  . ARG A 1 53  ? 176.35500 326.34600 20.60000  1.000 18.65106  ? 49  ARG F CB  1 
ATOM   183  C CG  . ARG A 1 53  ? 176.38300 325.06400 19.74800  1.000 16.43163  ? 49  ARG F CG  1 
ATOM   184  C CD  . ARG A 1 53  ? 177.12800 325.19900 18.39800  1.000 16.65330  ? 49  ARG F CD  1 
ATOM   185  N NE  . ARG A 1 53  ? 178.27300 326.09700 18.37900  1.000 20.49896  ? 49  ARG F NE  1 
ATOM   186  C CZ  . ARG A 1 53  ? 179.51400 325.71000 18.64500  1.000 23.91484  ? 49  ARG F CZ  1 
ATOM   187  N NH1 . ARG A 1 53  ? 179.80200 324.44200 18.94200  1.000 24.15224  ? 49  ARG F NH1 1 
ATOM   188  N NH2 . ARG A 1 53  ? 180.48700 326.60900 18.63600  1.000 14.51030  ? 49  ARG F NH2 1 
ATOM   189  N N   . THR A 1 54  ? 178.16000 324.52900 22.80300  1.000 20.47865  ? 50  THR F N   1 
ATOM   190  C CA  . THR A 1 54  ? 179.49200 324.08600 23.18800  1.000 24.33971  ? 50  THR F CA  1 
ATOM   191  C C   . THR A 1 54  ? 180.01600 322.92600 22.36600  1.000 24.92681  ? 50  THR F C   1 
ATOM   192  O O   . THR A 1 54  ? 181.23600 322.74500 22.32700  1.000 26.89612  ? 50  THR F O   1 
ATOM   193  C CB  . THR A 1 54  ? 179.52400 323.65600 24.66300  1.000 22.37891  ? 50  THR F CB  1 
ATOM   194  O OG1 . THR A 1 54  ? 178.61600 322.54700 24.86000  1.000 20.39707  ? 50  THR F OG1 1 
ATOM   195  C CG2 . THR A 1 54  ? 179.22900 324.83300 25.61400  1.000 20.29331  ? 50  THR F CG2 1 
ATOM   196  N N   . GLY A 1 55  ? 179.15800 322.20900 21.62100  1.000 21.68254  ? 51  GLY F N   1 
ATOM   197  C CA  . GLY A 1 55  ? 179.62900 321.09900 20.81800  1.000 20.82287  ? 51  GLY F CA  1 
ATOM   198  C C   . GLY A 1 55  ? 178.89000 321.03500 19.49300  1.000 25.34015  ? 51  GLY F C   1 
ATOM   199  O O   . GLY A 1 55  ? 177.98200 321.82200 19.23800  1.000 23.14616  ? 51  GLY F O   1 
ATOM   200  N N   . TRP A 1 56  ? 179.32300 320.10500 18.63900  1.000 24.24920  ? 52  TRP F N   1 
ATOM   201  C CA  . TRP A 1 56  ? 178.74200 319.89200 17.31600  1.000 25.57032  ? 52  TRP F CA  1 
ATOM   202  C C   . TRP A 1 56  ? 178.35200 318.43000 17.09900  1.000 27.65344  ? 52  TRP F C   1 
ATOM   203  O O   . TRP A 1 56  ? 179.05200 317.52200 17.55300  1.000 25.82151  ? 52  TRP F O   1 
ATOM   204  C CB  . TRP A 1 56  ? 179.68200 320.32800 16.18300  1.000 21.80995  ? 52  TRP F CB  1 
ATOM   205  C CG  . TRP A 1 56  ? 179.99400 321.80000 16.07800  1.000 23.40537  ? 52  TRP F CG  1 
ATOM   206  C CD1 . TRP A 1 56  ? 181.19900 322.40300 16.35400  1.000 23.27568  ? 52  TRP F CD1 1 
ATOM   207  C CD2 . TRP A 1 56  ? 179.10200 322.86100 15.67800  1.000 24.03406  ? 52  TRP F CD2 1 
ATOM   208  N NE1 . TRP A 1 56  ? 181.11200 323.75200 16.13100  1.000 23.13026  ? 52  TRP F NE1 1 
ATOM   209  C CE2 . TRP A 1 56  ? 179.84100 324.06300 15.71800  1.000 21.72597  ? 52  TRP F CE2 1 
ATOM   210  C CE3 . TRP A 1 56  ? 177.75800 322.90800 15.27400  1.000 25.01863  ? 52  TRP F CE3 1 
ATOM   211  C CZ2 . TRP A 1 56  ? 179.28700 325.29300 15.36600  1.000 19.41698  ? 52  TRP F CZ2 1 
ATOM   212  C CZ3 . TRP A 1 56  ? 177.20300 324.13900 14.93500  1.000 19.58079  ? 52  TRP F CZ3 1 
ATOM   213  C CH2 . TRP A 1 56  ? 177.96900 325.31100 14.98200  1.000 19.78741  ? 52  TRP F CH2 1 
ATOM   214  N N   . TYR A 1 57  ? 177.23900 318.19700 16.40700  1.000 19.13924  ? 53  TYR F N   1 
ATOM   215  C CA  . TYR A 1 57  ? 176.84800 316.85000 15.99500  1.000 23.09146  ? 53  TYR F CA  1 
ATOM   216  C C   . TYR A 1 57  ? 176.80000 316.82900 14.46200  1.000 27.11314  ? 53  TYR F C   1 
ATOM   217  O O   . TYR A 1 57  ? 176.08000 317.63500 13.85900  1.000 28.79399  ? 53  TYR F O   1 
ATOM   218  C CB  . TYR A 1 57  ? 175.51200 316.39600 16.58100  1.000 25.94026  ? 53  TYR F CB  1 
ATOM   219  C CG  . TYR A 1 57  ? 175.20600 315.03500 16.01600  1.000 39.16845  ? 53  TYR F CG  1 
ATOM   220  C CD1 . TYR A 1 57  ? 175.78800 313.90400 16.59000  1.000 35.44904  ? 53  TYR F CD1 1 
ATOM   221  C CD2 . TYR A 1 57  ? 174.42200 314.86900 14.88000  1.000 40.88996  ? 53  TYR F CD2 1 
ATOM   222  C CE1 . TYR A 1 57  ? 175.58500 312.65200 16.06900  1.000 40.35596  ? 53  TYR F CE1 1 
ATOM   223  C CE2 . TYR A 1 57  ? 174.20600 313.60800 14.35000  1.000 43.41704  ? 53  TYR F CE2 1 
ATOM   224  C CZ  . TYR A 1 57  ? 174.79000 312.50900 14.95000  1.000 44.65172  ? 53  TYR F CZ  1 
ATOM   225  O OH  . TYR A 1 57  ? 174.58800 311.26200 14.42900  1.000 51.63287  ? 53  TYR F OH  1 
ATOM   226  N N   . THR A 1 58  ? 177.70200 316.09000 13.81700  1.000 28.14263  ? 54  THR F N   1 
ATOM   227  C CA  . THR A 1 58  ? 177.70100 316.08700 12.35800  1.000 33.05197  ? 54  THR F CA  1 
ATOM   228  C C   . THR A 1 58  ? 176.83700 314.95700 11.82200  1.000 37.38726  ? 54  THR F C   1 
ATOM   229  O O   . THR A 1 58  ? 176.79600 313.86000 12.38300  1.000 41.83362  ? 54  THR F O   1 
ATOM   230  C CB  . THR A 1 58  ? 179.10700 315.91100 11.80700  1.000 33.13653  ? 54  THR F CB  1 
ATOM   231  O OG1 . THR A 1 58  ? 179.60400 314.65500 12.27000  1.000 39.57926  ? 54  THR F OG1 1 
ATOM   232  C CG2 . THR A 1 58  ? 180.01700 317.03200 12.27500  1.000 29.27505  ? 54  THR F CG2 1 
ATOM   233  N N   . SER A 1 59  ? 176.26900 315.18200 10.64100  1.000 39.54351  ? 55  SER F N   1 
ATOM   234  C CA  . SER A 1 59  ? 175.42400 314.17800 10.01100  1.000 35.34977  ? 55  SER F CA  1 
ATOM   235  C C   . SER A 1 59  ? 175.59100 314.24900 8.50400   1.000 34.11143  ? 55  SER F C   1 
ATOM   236  O O   . SER A 1 59  ? 175.80500 315.33100 7.96200   1.000 36.31058  ? 55  SER F O   1 
ATOM   237  C CB  . SER A 1 59  ? 173.96200 314.42000 10.38100  1.000 37.45670  ? 55  SER F CB  1 
ATOM   238  O OG  . SER A 1 59  ? 173.12900 313.42600 9.82500   1.000 44.51242  ? 55  SER F OG  1 
ATOM   239  N N   . VAL A 1 60  ? 175.59900 313.08600 7.83800   1.000 45.03010  ? 56  VAL F N   1 
ATOM   240  C CA  . VAL A 1 60  ? 175.80000 313.04300 6.38600   1.000 35.98581  ? 56  VAL F CA  1 
ATOM   241  C C   . VAL A 1 60  ? 174.45200 312.98500 5.67300   1.000 34.34978  ? 56  VAL F C   1 
ATOM   242  O O   . VAL A 1 60  ? 173.63000 312.09500 5.93600   1.000 38.16472  ? 56  VAL F O   1 
ATOM   243  C CB  . VAL A 1 60  ? 176.71000 311.87200 5.98900   1.000 36.84819  ? 56  VAL F CB  1 
ATOM   244  C CG1 . VAL A 1 60  ? 176.82500 311.77700 4.49000   1.000 38.25672  ? 56  VAL F CG1 1 
ATOM   245  C CG2 . VAL A 1 60  ? 178.08000 312.09300 6.58900   1.000 35.68987  ? 56  VAL F CG2 1 
ATOM   246  N N   . ILE A 1 61  ? 174.26200 313.88500 4.71900   1.000 33.40678  ? 57  ILE F N   1 
ATOM   247  C CA  . ILE A 1 61  ? 173.06100 313.96300 3.90000   1.000 39.84849  ? 57  ILE F CA  1 
ATOM   248  C C   . ILE A 1 61  ? 173.47100 313.63700 2.46900   1.000 36.99029  ? 57  ILE F C   1 
ATOM   249  O O   . ILE A 1 61  ? 174.41100 314.24700 1.93100   1.000 33.10672  ? 57  ILE F O   1 
ATOM   250  C CB  . ILE A 1 61  ? 172.38800 315.34700 3.97200   1.000 36.29037  ? 57  ILE F CB  1 
ATOM   251  C CG1 . ILE A 1 61  ? 172.27100 315.84900 5.42000   1.000 37.47790  ? 57  ILE F CG1 1 
ATOM   252  C CG2 . ILE A 1 61  ? 170.99100 315.28100 3.35600   1.000 35.01150  ? 57  ILE F CG2 1 
ATOM   253  C CD1 . ILE A 1 61  ? 171.46100 314.99700 6.33100   1.000 32.88097  ? 57  ILE F CD1 1 
ATOM   254  N N   . THR A 1 62  ? 172.90000 312.56400 1.92600   1.000 41.80837  ? 58  THR F N   1 
ATOM   255  C CA  . THR A 1 62  ? 173.21000 312.08900 0.58500   1.000 43.19443  ? 58  THR F CA  1 
ATOM   256  C C   . THR A 1 62  ? 172.04100 312.30400 -0.37500  1.000 40.61845  ? 58  THR F C   1 
ATOM   257  O O   . THR A 1 62  ? 170.85700 312.21700 -0.00600  1.000 40.82538  ? 58  THR F O   1 
ATOM   258  C CB  . THR A 1 62  ? 173.58900 310.59900 0.58600   1.000 32.94923  ? 58  THR F CB  1 
ATOM   259  O OG1 . THR A 1 62  ? 172.43000 309.82400 0.90200   1.000 44.77514  ? 58  THR F OG1 1 
ATOM   260  C CG2 . THR A 1 62  ? 174.70700 310.29200 1.56000   1.000 37.34694  ? 58  THR F CG2 1 
ATOM   261  N N   . ILE A 1 63  ? 172.40800 312.53600 -1.63000  1.000 40.74501  ? 59  ILE F N   1 
ATOM   262  C CA  . ILE A 1 63  ? 171.48700 312.60900 -2.75100  1.000 41.77665  ? 59  ILE F CA  1 
ATOM   263  C C   . ILE A 1 63  ? 172.06500 311.68500 -3.82400  1.000 43.01702  ? 59  ILE F C   1 
ATOM   264  O O   . ILE A 1 63  ? 173.17200 311.92000 -4.32500  1.000 42.94912  ? 59  ILE F O   1 
ATOM   265  C CB  . ILE A 1 63  ? 171.33100 314.03800 -3.28800  1.000 36.71125  ? 59  ILE F CB  1 
ATOM   266  C CG1 . ILE A 1 63  ? 170.58500 314.92100 -2.28300  1.000 38.10481  ? 59  ILE F CG1 1 
ATOM   267  C CG2 . ILE A 1 63  ? 170.60300 314.03300 -4.62000  1.000 38.52298  ? 59  ILE F CG2 1 
ATOM   268  C CD1 . ILE A 1 63  ? 170.34500 316.32500 -2.79500  1.000 31.04303  ? 59  ILE F CD1 1 
ATOM   269  N N   . GLU A 1 64  ? 171.34700 310.61200 -4.12800  1.000 42.88265  ? 60  GLU F N   1 
ATOM   270  C CA  . GLU A 1 64  ? 171.76600 309.61500 -5.11200  1.000 44.38762  ? 60  GLU F CA  1 
ATOM   271  C C   . GLU A 1 64  ? 171.59900 310.16600 -6.53000  1.000 40.73294  ? 60  GLU F C   1 
ATOM   272  O O   . GLU A 1 64  ? 170.49800 310.57800 -6.91000  1.000 39.10908  ? 60  GLU F O   1 
ATOM   273  C CB  . GLU A 1 64  ? 171.02200 308.30300 -4.90100  1.000 51.03887  ? 60  GLU F CB  1 
ATOM   274  C CG  . GLU A 1 64  ? 171.72400 307.43400 -3.84500  1.000 56.59938  ? 60  GLU F CG  1 
ATOM   275  C CD  . GLU A 1 64  ? 171.92800 305.99700 -4.29400  1.000 65.78600  ? 60  GLU F CD  1 
ATOM   276  O OE1 . GLU A 1 64  ? 170.92300 305.24900 -4.38700  1.000 58.07366  ? 60  GLU F OE1 1 
ATOM   277  O OE2 . GLU A 1 64  ? 173.09700 305.62900 -4.56700  1.000 65.64526  ? 60  GLU F OE2 1 
ATOM   278  N N   . LEU A 1 65  ? 172.70100 310.32400 -7.25100  1.000 41.25973  ? 61  LEU F N   1 
ATOM   279  C CA  . LEU A 1 65  ? 172.68800 310.88600 -8.59300  1.000 39.92479  ? 61  LEU F CA  1 
ATOM   280  C C   . LEU A 1 65  ? 172.84600 309.79800 -9.66500  1.000 54.04450  ? 61  LEU F C   1 
ATOM   281  O O   . LEU A 1 65  ? 173.18300 308.64600 -9.38700  1.000 52.31853  ? 61  LEU F O   1 
ATOM   282  C CB  . LEU A 1 65  ? 173.81700 311.90800 -8.72100  1.000 45.42456  ? 61  LEU F CB  1 
ATOM   283  C CG  . LEU A 1 65  ? 173.67400 313.15800 -7.85000  1.000 43.12155  ? 61  LEU F CG  1 
ATOM   284  C CD1 . LEU A 1 65  ? 174.79900 314.12600 -8.16500  1.000 46.14883  ? 61  LEU F CD1 1 
ATOM   285  C CD2 . LEU A 1 65  ? 172.33800 313.82600 -8.08800  1.000 36.83441  ? 61  LEU F CD2 1 
ATOM   286  N N   . SER A 1 66  ? 172.58700 310.17800 -10.91400 1.000 48.18957  ? 62  SER F N   1 
ATOM   287  C CA  . SER A 1 66  ? 172.67700 309.26300 -12.04500 1.000 49.14242  ? 62  SER F CA  1 
ATOM   288  C C   . SER A 1 66  ? 173.84700 309.65600 -12.92800 1.000 55.22286  ? 62  SER F C   1 
ATOM   289  O O   . SER A 1 66  ? 173.88600 310.77300 -13.45600 1.000 47.59629  ? 62  SER F O   1 
ATOM   290  C CB  . SER A 1 66  ? 171.39700 309.27200 -12.87600 1.000 51.58485  ? 62  SER F CB  1 
ATOM   291  O OG  . SER A 1 66  ? 171.49200 308.31500 -13.91300 1.000 57.83382  ? 62  SER F OG  1 
ATOM   292  N N   . ASN A 1 67  ? 174.80600 308.74600 -13.07200 1.000 65.16513  ? 63  ASN F N   1 
ATOM   293  C CA  . ASN A 1 67  ? 175.95100 309.00400 -13.93600 1.000 71.22377  ? 63  ASN F CA  1 
ATOM   294  C C   . ASN A 1 67  ? 175.48200 308.69500 -15.34900 1.000 75.01008  ? 63  ASN F C   1 
ATOM   295  O O   . ASN A 1 67  ? 175.57000 307.56200 -15.82400 1.000 87.17122  ? 63  ASN F O   1 
ATOM   296  C CB  . ASN A 1 67  ? 177.15500 308.16800 -13.51800 1.000 76.59846  ? 63  ASN F CB  1 
ATOM   297  C CG  . ASN A 1 67  ? 178.44100 308.64200 -14.16700 1.000 91.06393  ? 63  ASN F CG  1 
ATOM   298  O OD1 . ASN A 1 67  ? 178.43000 309.17800 -15.27800 1.000 99.98829  ? 63  ASN F OD1 1 
ATOM   299  N ND2 . ASN A 1 67  ? 179.55900 308.47200 -13.46200 1.000 90.65257  ? 63  ASN F ND2 1 
ATOM   300  N N   . ILE A 1 68  ? 174.97900 309.70800 -16.03900 1.000 71.83064  ? 64  ILE F N   1 
ATOM   301  C CA  . ILE A 1 68  ? 174.49900 309.52800 -17.39900 1.000 80.88670  ? 64  ILE F CA  1 
ATOM   302  C C   . ILE A 1 68  ? 175.13500 310.59300 -18.27400 1.000 82.25577  ? 64  ILE F C   1 
ATOM   303  O O   . ILE A 1 68  ? 175.46600 311.69000 -17.81400 1.000 84.74602  ? 64  ILE F O   1 
ATOM   304  C CB  . ILE A 1 68  ? 172.95200 309.55300 -17.47400 1.000 75.52980  ? 64  ILE F CB  1 
ATOM   305  C CG1 . ILE A 1 68  ? 172.38500 310.85000 -16.90200 1.000 67.38435  ? 64  ILE F CG1 1 
ATOM   306  C CG2 . ILE A 1 68  ? 172.36300 308.35000 -16.75700 1.000 76.47653  ? 64  ILE F CG2 1 
ATOM   307  C CD1 . ILE A 1 68  ? 171.93900 311.81800 -17.94200 1.000 67.36349  ? 64  ILE F CD1 1 
ATOM   308  N N   . LYS A 1 69  ? 175.27600 310.26800 -19.55200 1.000 85.33386  ? 65  LYS F N   1 
ATOM   309  C CA  . LYS A 1 69  ? 175.77700 311.19000 -20.55700 1.000 93.61613  ? 65  LYS F CA  1 
ATOM   310  C C   . LYS A 1 69  ? 174.69300 311.50900 -21.57800 1.000 96.95609  ? 65  LYS F C   1 
ATOM   311  O O   . LYS A 1 69  ? 173.68800 310.80100 -21.69800 1.000 94.25128  ? 65  LYS F O   1 
ATOM   312  C CB  . LYS A 1 69  ? 177.02200 310.61100 -21.24800 1.000 97.59099  ? 65  LYS F CB  1 
ATOM   313  C CG  . LYS A 1 69  ? 178.21300 310.35000 -20.30900 1.000 97.45517  ? 65  LYS F CG  1 
ATOM   314  C CD  . LYS A 1 69  ? 178.30800 308.88100 -19.88400 1.000 96.04805  ? 65  LYS F CD  1 
ATOM   315  C CE  . LYS A 1 69  ? 179.57600 308.59900 -19.07500 1.000 95.34145  ? 65  LYS F CE  1 
ATOM   316  N NZ  . LYS A 1 69  ? 179.65000 309.37100 -17.80100 1.000 91.51199  ? 65  LYS F NZ  1 
ATOM   317  N N   . GLU A 1 70  ? 174.92800 312.58300 -22.33100 1.000 101.02663 ? 66  GLU F N   1 
ATOM   318  C CA  . GLU A 1 70  ? 173.92000 313.08200 -23.25400 1.000 100.59739 ? 66  GLU F CA  1 
ATOM   319  C C   . GLU A 1 70  ? 173.61900 312.08700 -24.36200 1.000 97.27009  ? 66  GLU F C   1 
ATOM   320  O O   . GLU A 1 70  ? 174.52300 311.48900 -24.95300 1.000 91.89727  ? 66  GLU F O   1 
ATOM   321  C CB  . GLU A 1 70  ? 174.39400 314.39000 -23.89900 1.000 103.39945 ? 66  GLU F CB  1 
ATOM   322  C CG  . GLU A 1 70  ? 174.20000 315.65500 -23.08200 1.000 103.33059 ? 66  GLU F CG  1 
ATOM   323  C CD  . GLU A 1 70  ? 174.86300 316.85900 -23.73800 1.000 109.45801 ? 66  GLU F CD  1 
ATOM   324  O OE1 . GLU A 1 70  ? 175.55000 316.67400 -24.77200 1.000 103.95150 ? 66  GLU F OE1 1 
ATOM   325  O OE2 . GLU A 1 70  ? 174.69700 317.98700 -23.22200 1.000 106.07203 ? 66  GLU F OE2 1 
ATOM   326  N N   . ASN A 1 71  ? 172.32800 311.92900 -24.64700 1.000 94.75993  ? 67  ASN F N   1 
ATOM   327  C CA  . ASN A 1 71  ? 171.85300 311.08200 -25.72500 1.000 90.17344  ? 67  ASN F CA  1 
ATOM   328  C C   . ASN A 1 71  ? 170.88600 311.91500 -26.55100 1.000 95.44134  ? 67  ASN F C   1 
ATOM   329  O O   . ASN A 1 71  ? 170.02200 312.60900 -26.00500 1.000 97.25652  ? 67  ASN F O   1 
ATOM   330  C CB  . ASN A 1 71  ? 171.19200 309.79300 -25.20400 1.000 90.21899  ? 67  ASN F CB  1 
ATOM   331  C CG  . ASN A 1 71  ? 172.10600 308.99800 -24.26600 1.000 94.82538  ? 67  ASN F CG  1 
ATOM   332  O OD1 . ASN A 1 71  ? 172.96800 308.23800 -24.71400 1.000 92.06578  ? 67  ASN F OD1 1 
ATOM   333  N ND2 . ASN A 1 71  ? 171.92100 309.17600 -22.96400 1.000 88.59324  ? 67  ASN F ND2 1 
ATOM   334  N N   . LYS A 1 72  ? 171.02900 311.86400 -27.85300 1.000 102.64319 ? 68  LYS F N   1 
ATOM   335  C CA  . LYS A 1 72  ? 170.14200 312.61700 -28.69600 1.000 107.33787 ? 68  LYS F CA  1 
ATOM   336  C C   . LYS A 1 72  ? 169.43200 311.57600 -29.50200 1.000 112.85559 ? 68  LYS F C   1 
ATOM   337  O O   . LYS A 1 72  ? 170.08400 310.70600 -30.07800 1.000 109.24054 ? 68  LYS F O   1 
ATOM   338  C CB  . LYS A 1 72  ? 170.92900 313.57800 -29.56600 1.000 104.94873 ? 68  LYS F CB  1 
ATOM   339  C CG  . LYS A 1 72  ? 170.06800 314.41000 -30.50300 1.000 105.12207 ? 68  LYS F CG  1 
ATOM   340  C CD  . LYS A 1 72  ? 170.83000 314.77500 -31.76800 1.000 98.57413  ? 68  LYS F CD  1 
ATOM   341  C CE  . LYS A 1 72  ? 171.82000 313.68700 -32.15400 1.000 90.87280  ? 68  LYS F CE  1 
ATOM   342  N NZ  . LYS A 1 72  ? 172.12100 313.70300 -33.61100 1.000 78.63685  ? 68  LYS F NZ  1 
ATOM   343  N N   . CYS A 1 73  ? 168.10400 311.63600 -29.55700 1.000 112.54899 ? 69  CYS F N   1 
ATOM   344  C CA  . CYS A 1 73  ? 167.37600 310.56300 -30.22500 1.000 108.31795 ? 69  CYS F CA  1 
ATOM   345  C C   . CYS A 1 73  ? 166.33900 310.99100 -31.23300 1.000 106.94861 ? 69  CYS F C   1 
ATOM   346  O O   . CYS A 1 73  ? 165.24100 310.45200 -31.23700 1.000 109.18915 ? 69  CYS F O   1 
ATOM   347  C CB  . CYS A 1 73  ? 166.67100 309.79100 -29.16000 1.000 100.48823 ? 69  CYS F CB  1 
ATOM   348  S SG  . CYS A 1 73  ? 165.80400 311.01400 -28.20000 1.000 116.56096 ? 69  CYS F SG  1 
ATOM   349  N N   . ASN A 1 74  ? 166.66500 311.92700 -32.10500 1.000 106.13341 ? 70  ASN F N   1 
ATOM   350  C CA  . ASN A 1 74  ? 165.73200 312.28100 -33.16000 1.000 103.99682 ? 70  ASN F CA  1 
ATOM   351  C C   . ASN A 1 74  ? 164.40700 312.62800 -32.55300 1.000 101.55080 ? 70  ASN F C   1 
ATOM   352  O O   . ASN A 1 74  ? 163.36300 312.45300 -33.16800 1.000 101.57287 ? 70  ASN F O   1 
ATOM   353  C CB  . ASN A 1 74  ? 165.57500 311.11700 -34.11500 1.000 103.73314 ? 70  ASN F CB  1 
ATOM   354  C CG  . ASN A 1 74  ? 166.85300 310.80300 -34.85500 1.000 108.74824 ? 70  ASN F CG  1 
ATOM   355  O OD1 . ASN A 1 74  ? 167.78800 311.60300 -34.86100 1.000 113.15258 ? 70  ASN F OD1 1 
ATOM   356  N ND2 . ASN A 1 74  ? 166.90400 309.63500 -35.48300 1.000 102.25832 ? 70  ASN F ND2 1 
ATOM   357  N N   . GLY A 1 75  ? 164.44500 313.14200 -31.34700 1.000 94.19666  ? 71  GLY F N   1 
ATOM   358  C CA  . GLY A 1 75  ? 163.22500 313.47900 -30.63600 1.000 85.47869  ? 71  GLY F CA  1 
ATOM   359  C C   . GLY A 1 75  ? 162.71500 314.89200 -30.87900 1.000 78.43171  ? 71  GLY F C   1 
ATOM   360  O O   . GLY A 1 75  ? 163.48300 315.85100 -30.94500 1.000 81.37521  ? 71  GLY F O   1 
ATOM   361  N N   . THR A 1 76  ? 161.39300 315.00200 -31.04700 1.000 72.72159  ? 72  THR F N   1 
ATOM   362  C CA  . THR A 1 76  ? 160.76000 316.29500 -31.29000 1.000 59.40390  ? 72  THR F CA  1 
ATOM   363  C C   . THR A 1 76  ? 159.42900 316.36600 -30.55800 1.000 49.16529  ? 72  THR F C   1 
ATOM   364  O O   . THR A 1 76  ? 158.80900 317.43200 -30.55700 1.000 52.63587  ? 72  THR F O   1 
ATOM   365  C CB  . THR A 1 76  ? 160.54200 316.59600 -32.78600 1.000 61.21268  ? 72  THR F CB  1 
ATOM   366  O OG1 . THR A 1 76  ? 160.67500 318.00300 -32.99100 1.000 59.87871  ? 72  THR F OG1 1 
ATOM   367  C CG2 . THR A 1 76  ? 159.12400 316.27800 -33.21400 1.000 57.17234  ? 72  THR F CG2 1 
ATOM   368  N N   . ASP A 1 77  ? 158.92900 315.25700 -30.00600 1.000 46.35550  ? 73  ASP F N   1 
ATOM   369  C CA  . ASP A 1 77  ? 157.63600 315.28500 -29.34000 1.000 49.52640  ? 73  ASP F CA  1 
ATOM   370  C C   . ASP A 1 77  ? 157.70700 316.21000 -28.12200 1.000 42.09229  ? 73  ASP F C   1 
ATOM   371  O O   . ASP A 1 77  ? 158.75000 316.31100 -27.46700 1.000 38.50122  ? 73  ASP F O   1 
ATOM   372  C CB  . ASP A 1 77  ? 157.30700 313.84200 -28.92400 1.000 43.00009  ? 73  ASP F CB  1 
ATOM   373  C CG  . ASP A 1 77  ? 156.18200 313.74300 -27.94300 1.000 49.58642  ? 73  ASP F CG  1 
ATOM   374  O OD1 . ASP A 1 77  ? 155.01800 313.68300 -28.39100 1.000 49.94747  ? 73  ASP F OD1 1 
ATOM   375  O OD2 . ASP A 1 77  ? 156.46500 313.71400 -26.72000 1.000 51.55305  ? 73  ASP F OD2 1 
ATOM   376  N N   . ALA A 1 78  ? 156.59700 316.90500 -27.81600 1.000 36.09965  ? 74  ALA F N   1 
ATOM   377  C CA  . ALA A 1 78  ? 156.73000 317.98900 -26.83800 1.000 35.82093  ? 74  ALA F CA  1 
ATOM   378  C C   . ALA A 1 78  ? 157.12600 317.48600 -25.43900 1.000 36.62046  ? 74  ALA F C   1 
ATOM   379  O O   . ALA A 1 78  ? 157.86600 318.16600 -24.70800 1.000 37.53501  ? 74  ALA F O   1 
ATOM   380  C CB  . ALA A 1 78  ? 155.41700 318.76700 -26.76300 1.000 32.95207  ? 74  ALA F CB  1 
ATOM   381  N N   . LYS A 1 79  ? 156.69500 316.26700 -25.07900 1.000 32.12420  ? 75  LYS F N   1 
ATOM   382  C CA  . LYS A 1 79  ? 157.00100 315.72100 -23.75600 1.000 30.30353  ? 75  LYS F CA  1 
ATOM   383  C C   . LYS A 1 79  ? 158.46800 315.34300 -23.63900 1.000 33.31055  ? 75  LYS F C   1 
ATOM   384  O O   . LYS A 1 79  ? 159.10500 315.57300 -22.60200 1.000 36.74891  ? 75  LYS F O   1 
ATOM   385  C CB  . LYS A 1 79  ? 156.08600 314.55400 -23.39600 1.000 30.81095  ? 75  LYS F CB  1 
ATOM   386  C CG  . LYS A 1 79  ? 154.71200 315.01000 -22.90600 1.000 29.60521  ? 75  LYS F CG  1 
ATOM   387  C CD  . LYS A 1 79  ? 153.76600 313.84300 -22.53500 1.000 36.30616  ? 75  LYS F CD  1 
ATOM   388  C CE  . LYS A 1 79  ? 153.37000 312.95200 -23.69800 1.000 34.21371  ? 75  LYS F CE  1 
ATOM   389  N NZ  . LYS A 1 79  ? 152.56500 313.74200 -24.67400 1.000 37.24022  ? 75  LYS F NZ  1 
ATOM   390  N N   . VAL A 1 80  ? 159.03100 314.84100 -24.73600 1.000 38.20948  ? 76  VAL F N   1 
ATOM   391  C CA  . VAL A 1 80  ? 160.44500 314.49600 -24.78900 1.000 36.60629  ? 76  VAL F CA  1 
ATOM   392  C C   . VAL A 1 80  ? 161.28300 315.75200 -24.67900 1.000 32.12451  ? 76  VAL F C   1 
ATOM   393  O O   . VAL A 1 80  ? 162.31500 315.75700 -24.00700 1.000 34.56062  ? 76  VAL F O   1 
ATOM   394  C CB  . VAL A 1 80  ? 160.75500 313.71500 -26.08100 1.000 39.33439  ? 76  VAL F CB  1 
ATOM   395  C CG1 . VAL A 1 80  ? 162.26300 313.53100 -26.27200 1.000 37.34801  ? 76  VAL F CG1 1 
ATOM   396  C CG2 . VAL A 1 80  ? 160.07600 312.36200 -26.04300 1.000 39.46123  ? 76  VAL F CG2 1 
ATOM   397  N N   . LYS A 1 81  ? 160.85300 316.83400 -25.33100 1.000 34.38754  ? 77  LYS F N   1 
ATOM   398  C CA  . LYS A 1 81  ? 161.58400 318.09100 -25.23200 1.000 38.66001  ? 77  LYS F CA  1 
ATOM   399  C C   . LYS A 1 81  ? 161.61100 318.57100 -23.79100 1.000 38.88683  ? 77  LYS F C   1 
ATOM   400  O O   . LYS A 1 81  ? 162.65800 318.98900 -23.28000 1.000 39.15238  ? 77  LYS F O   1 
ATOM   401  C CB  . LYS A 1 81  ? 160.87500 319.15500 -26.06500 1.000 37.18955  ? 77  LYS F CB  1 
ATOM   402  C CG  . LYS A 1 81  ? 161.60600 320.48000 -26.29400 1.000 46.01858  ? 77  LYS F CG  1 
ATOM   403  C CD  . LYS A 1 81  ? 160.59200 321.43900 -26.91500 1.000 52.78073  ? 77  LYS F CD  1 
ATOM   404  C CE  . LYS A 1 81  ? 159.46500 321.67400 -25.85000 1.000 60.69173  ? 77  LYS F CE  1 
ATOM   405  N NZ  . LYS A 1 81  ? 158.01500 321.45400 -26.23800 1.000 53.90165  ? 77  LYS F NZ  1 
ATOM   406  N N   . LEU A 1 82  ? 160.47100 318.48300 -23.10300 1.000 39.40853  ? 78  LEU F N   1 
ATOM   407  C CA  . LEU A 1 82  ? 160.43600 318.95900 -21.72700 1.000 35.06824  ? 78  LEU F CA  1 
ATOM   408  C C   . LEU A 1 82  ? 161.37000 318.13200 -20.85700 1.000 35.05300  ? 78  LEU F C   1 
ATOM   409  O O   . LEU A 1 82  ? 162.11400 318.67300 -20.02800 1.000 35.40415  ? 78  LEU F O   1 
ATOM   410  C CB  . LEU A 1 82  ? 159.01000 318.88800 -21.19600 1.000 30.76901  ? 78  LEU F CB  1 
ATOM   411  C CG  . LEU A 1 82  ? 158.09700 319.93900 -21.81600 1.000 35.97933  ? 78  LEU F CG  1 
ATOM   412  C CD1 . LEU A 1 82  ? 156.64600 319.64200 -21.42500 1.000 29.90426  ? 78  LEU F CD1 1 
ATOM   413  C CD2 . LEU A 1 82  ? 158.54000 321.32800 -21.38000 1.000 35.84759  ? 78  LEU F CD2 1 
ATOM   414  N N   . ILE A 1 83  ? 161.38200 316.81700 -21.07500 1.000 32.34791  ? 79  ILE F N   1 
ATOM   415  C CA  . ILE A 1 83  ? 162.26500 315.94600 -20.31300 1.000 27.22225  ? 79  ILE F CA  1 
ATOM   416  C C   . ILE A 1 83  ? 163.73500 316.26400 -20.59700 1.000 35.13726  ? 79  ILE F C   1 
ATOM   417  O O   . ILE A 1 83  ? 164.54400 316.34200 -19.67100 1.000 38.53128  ? 79  ILE F O   1 
ATOM   418  C CB  . ILE A 1 83  ? 161.92800 314.47300 -20.57800 1.000 32.70073  ? 79  ILE F CB  1 
ATOM   419  C CG1 . ILE A 1 83  ? 160.72800 314.04900 -19.73900 1.000 41.07352  ? 79  ILE F CG1 1 
ATOM   420  C CG2 . ILE A 1 83  ? 163.09700 313.59200 -20.22400 1.000 34.81355  ? 79  ILE F CG2 1 
ATOM   421  C CD1 . ILE A 1 83  ? 160.94500 314.16100 -18.23700 1.000 36.16155  ? 79  ILE F CD1 1 
ATOM   422  N N   . LYS A 1 84  ? 164.12700 316.40900 -21.87400 1.000 37.13818  ? 80  LYS F N   1 
ATOM   423  C CA  . LYS A 1 84  ? 165.54200 316.71400 -22.12900 1.000 34.67833  ? 80  LYS F CA  1 
ATOM   424  C C   . LYS A 1 84  ? 165.95000 318.06900 -21.57300 1.000 37.88021  ? 80  LYS F C   1 
ATOM   425  O O   . LYS A 1 84  ? 167.08700 318.23200 -21.12900 1.000 40.74538  ? 80  LYS F O   1 
ATOM   426  C CB  . LYS A 1 84  ? 165.97700 316.65000 -23.59900 1.000 39.94619  ? 80  LYS F CB  1 
ATOM   427  C CG  . LYS A 1 84  ? 165.87500 315.32600 -24.37500 1.000 41.91182  ? 80  LYS F CG  1 
ATOM   428  C CD  . LYS A 1 84  ? 166.26700 315.60000 -25.83800 1.000 49.92442  ? 80  LYS F CD  1 
ATOM   429  C CE  . LYS A 1 84  ? 165.38800 315.03600 -26.92000 1.000 64.38832  ? 80  LYS F CE  1 
ATOM   430  N NZ  . LYS A 1 84  ? 164.94500 316.15800 -27.82800 1.000 67.74762  ? 80  LYS F NZ  1 
ATOM   431  N N   . GLN A 1 85  ? 165.03800 319.03800 -21.55400 1.000 39.51932  ? 81  GLN F N   1 
ATOM   432  C CA  . GLN A 1 85  ? 165.34400 320.33000 -20.95400 1.000 36.83479  ? 81  GLN F CA  1 
ATOM   433  C C   . GLN A 1 85  ? 165.61200 320.17400 -19.46700 1.000 42.66537  ? 81  GLN F C   1 
ATOM   434  O O   . GLN A 1 85  ? 166.60400 320.70000 -18.92900 1.000 44.57151  ? 81  GLN F O   1 
ATOM   435  C CB  . GLN A 1 85  ? 164.17500 321.28600 -21.17900 1.000 39.01859  ? 81  GLN F CB  1 
ATOM   436  C CG  . GLN A 1 85  ? 164.07700 321.85400 -22.58000 1.000 44.06073  ? 81  GLN F CG  1 
ATOM   437  C CD  . GLN A 1 85  ? 163.01000 322.93800 -22.69800 1.000 54.67776  ? 81  GLN F CD  1 
ATOM   438  O OE1 . GLN A 1 85  ? 162.83800 323.54200 -23.75600 1.000 59.50819  ? 81  GLN F OE1 1 
ATOM   439  N NE2 . GLN A 1 85  ? 162.29800 323.19600 -21.60100 1.000 56.28555  ? 81  GLN F NE2 1 
ATOM   440  N N   . GLU A 1 86  ? 164.72400 319.46100 -18.77700 1.000 34.05863  ? 82  GLU F N   1 
ATOM   441  C CA  . GLU A 1 86  ? 164.95600 319.25100 -17.36300 1.000 38.47698  ? 82  GLU F CA  1 
ATOM   442  C C   . GLU A 1 86  ? 166.22600 318.41900 -17.13500 1.000 37.09804  ? 82  GLU F C   1 
ATOM   443  O O   . GLU A 1 86  ? 166.93600 318.61600 -16.14200 1.000 36.82863  ? 82  GLU F O   1 
ATOM   444  C CB  . GLU A 1 86  ? 163.71800 318.57900 -16.77200 1.000 36.43455  ? 82  GLU F CB  1 
ATOM   445  C CG  . GLU A 1 86  ? 163.72300 318.49700 -15.28600 1.000 39.84075  ? 82  GLU F CG  1 
ATOM   446  C CD  . GLU A 1 86  ? 163.59300 319.92400 -14.71400 1.000 44.92188  ? 82  GLU F CD  1 
ATOM   447  O OE1 . GLU A 1 86  ? 163.09300 320.80200 -15.45800 1.000 44.94832  ? 82  GLU F OE1 1 
ATOM   448  O OE2 . GLU A 1 86  ? 163.99800 320.17800 -13.55600 1.000 48.14262  ? 82  GLU F OE2 1 
ATOM   449  N N   . LEU A 1 87  ? 166.56200 317.52500 -18.07000 1.000 37.96132  ? 83  LEU F N   1 
ATOM   450  C CA  . LEU A 1 87  ? 167.78400 316.73800 -17.94200 1.000 39.22470  ? 83  LEU F CA  1 
ATOM   451  C C   . LEU A 1 87  ? 169.03200 317.59500 -18.13200 1.000 43.79419  ? 83  LEU F C   1 
ATOM   452  O O   . LEU A 1 87  ? 170.07000 317.32300 -17.52100 1.000 40.76547  ? 83  LEU F O   1 
ATOM   453  C CB  . LEU A 1 87  ? 167.77000 315.58500 -18.93900 1.000 37.78579  ? 83  LEU F CB  1 
ATOM   454  C CG  . LEU A 1 87  ? 167.16100 314.29800 -18.38100 1.000 46.27965  ? 83  LEU F CG  1 
ATOM   455  C CD1 . LEU A 1 87  ? 167.06600 313.20500 -19.44600 1.000 41.03980  ? 83  LEU F CD1 1 
ATOM   456  C CD2 . LEU A 1 87  ? 167.94500 313.83200 -17.17200 1.000 37.24642  ? 83  LEU F CD2 1 
ATOM   457  N N   . ASP A 1 88  ? 168.96700 318.61800 -18.98800 1.000 44.23178  ? 84  ASP F N   1 
ATOM   458  C CA  . ASP A 1 88  ? 170.12600 319.49600 -19.11600 1.000 48.23610  ? 84  ASP F CA  1 
ATOM   459  C C   . ASP A 1 88  ? 170.29200 320.34800 -17.86900 1.000 46.50173  ? 84  ASP F C   1 
ATOM   460  O O   . ASP A 1 88  ? 171.42100 320.59900 -17.42100 1.000 44.95069  ? 84  ASP F O   1 
ATOM   461  C CB  . ASP A 1 88  ? 169.99600 320.39400 -20.34900 1.000 51.68137  ? 84  ASP F CB  1 
ATOM   462  C CG  . ASP A 1 88  ? 170.15100 319.63100 -21.65600 1.000 59.32703  ? 84  ASP F CG  1 
ATOM   463  O OD1 . ASP A 1 88  ? 170.72600 318.51400 -21.65200 1.000 58.58478  ? 84  ASP F OD1 1 
ATOM   464  O OD2 . ASP A 1 88  ? 169.71100 320.16600 -22.69700 1.000 67.13588  ? 84  ASP F OD2 1 
ATOM   465  N N   . LYS A 1 89  ? 169.18000 320.76600 -17.26200 1.000 44.56308  ? 85  LYS F N   1 
ATOM   466  C CA  . LYS A 1 89  ? 169.32700 321.47000 -15.99100 1.000 43.16115  ? 85  LYS F CA  1 
ATOM   467  C C   . LYS A 1 89  ? 169.89000 320.56200 -14.89800 1.000 43.45346  ? 85  LYS F C   1 
ATOM   468  O O   . LYS A 1 89  ? 170.70700 321.00900 -14.07600 1.000 41.05390  ? 85  LYS F O   1 
ATOM   469  C CB  . LYS A 1 89  ? 167.99300 322.05700 -15.53800 1.000 38.54576  ? 85  LYS F CB  1 
ATOM   470  C CG  . LYS A 1 89  ? 167.55200 323.31500 -16.28000 1.000 39.97948  ? 85  LYS F CG  1 
ATOM   471  C CD  . LYS A 1 89  ? 166.03600 323.36500 -16.46000 1.000 42.98845  ? 85  LYS F CD  1 
ATOM   472  C CE  . LYS A 1 89  ? 165.32400 323.51700 -15.11300 1.000 53.86460  ? 85  LYS F CE  1 
ATOM   473  N NZ  . LYS A 1 89  ? 163.81500 323.53000 -15.17400 1.000 53.43487  ? 85  LYS F NZ  1 
ATOM   474  N N   . TYR A 1 90  ? 169.58100 319.26200 -14.95400 1.000 41.05787  ? 86  TYR F N   1 
ATOM   475  C CA  . TYR A 1 90  ? 170.23800 318.32600 -14.04500 1.000 38.19964  ? 86  TYR F CA  1 
ATOM   476  C C   . TYR A 1 90  ? 171.72800 318.16800 -14.34100 1.000 37.93668  ? 86  TYR F C   1 
ATOM   477  O O   . TYR A 1 90  ? 172.55300 318.11600 -13.41600 1.000 41.20436  ? 86  TYR F O   1 
ATOM   478  C CB  . TYR A 1 90  ? 169.54300 316.97200 -14.16700 1.000 34.66983  ? 86  TYR F CB  1 
ATOM   479  C CG  . TYR A 1 90  ? 170.24200 315.81200 -13.51500 1.000 29.44592  ? 86  TYR F CG  1 
ATOM   480  C CD1 . TYR A 1 90  ? 170.07800 315.52300 -12.17100 1.000 32.57830  ? 86  TYR F CD1 1 
ATOM   481  C CD2 . TYR A 1 90  ? 171.07300 314.98800 -14.26700 1.000 31.19907  ? 86  TYR F CD2 1 
ATOM   482  C CE1 . TYR A 1 90  ? 170.72800 314.43400 -11.58600 1.000 32.88249  ? 86  TYR F CE1 1 
ATOM   483  C CE2 . TYR A 1 90  ? 171.72400 313.90800 -13.69700 1.000 33.28880  ? 86  TYR F CE2 1 
ATOM   484  C CZ  . TYR A 1 90  ? 171.55200 313.63400 -12.36800 1.000 32.61860  ? 86  TYR F CZ  1 
ATOM   485  O OH  . TYR A 1 90  ? 172.21000 312.55200 -11.83500 1.000 38.00315  ? 86  TYR F OH  1 
ATOM   486  N N   . LYS A 1 91  ? 172.11600 318.14700 -15.60900 1.000 34.33080  ? 87  LYS F N   1 
ATOM   487  C CA  . LYS A 1 91  ? 173.53800 317.94000 -15.85500 1.000 44.83234  ? 87  LYS F CA  1 
ATOM   488  C C   . LYS A 1 91  ? 174.35200 319.15300 -15.47800 1.000 44.96272  ? 87  LYS F C   1 
ATOM   489  O O   . LYS A 1 91  ? 175.46700 319.00800 -14.96900 1.000 46.32913  ? 87  LYS F O   1 
ATOM   490  C CB  . LYS A 1 91  ? 173.83500 317.50400 -17.27900 1.000 41.87345  ? 87  LYS F CB  1 
ATOM   491  C CG  . LYS A 1 91  ? 173.35400 316.10500 -17.56300 1.000 55.25182  ? 87  LYS F CG  1 
ATOM   492  C CD  . LYS A 1 91  ? 173.38300 315.78100 -19.05200 1.000 64.48635  ? 87  LYS F CD  1 
ATOM   493  C CE  . LYS A 1 91  ? 172.76100 314.41400 -19.34500 1.000 78.72539  ? 87  LYS F CE  1 
ATOM   494  N NZ  . LYS A 1 91  ? 172.56900 314.19600 -20.80900 1.000 84.27795  ? 87  LYS F NZ  1 
ATOM   495  N N   . ASN A 1 92  ? 173.82400 320.35000 -15.73600 1.000 43.29875  ? 88  ASN F N   1 
ATOM   496  C CA  A ASN A 1 92  ? 174.52400 321.55800 -15.32900 0.730 41.55044  ? 88  ASN F CA  1 
ATOM   497  C CA  B ASN A 1 92  ? 174.52400 321.56200 -15.32900 0.270 41.71946  ? 88  ASN F CA  1 
ATOM   498  C C   . ASN A 1 92  ? 174.58800 321.68000 -13.81400 1.000 48.81881  ? 88  ASN F C   1 
ATOM   499  O O   . ASN A 1 92  ? 175.58100 322.18100 -13.27700 1.000 48.02004  ? 88  ASN F O   1 
ATOM   500  C CB  A ASN A 1 92  ? 173.84900 322.76400 -15.96500 0.730 43.24990  ? 88  ASN F CB  1 
ATOM   501  C CB  B ASN A 1 92  ? 173.86800 322.79500 -15.96000 0.270 43.29167  ? 88  ASN F CB  1 
ATOM   502  C CG  A ASN A 1 92  ? 174.00900 322.77500 -17.46900 0.730 41.19530  ? 88  ASN F CG  1 
ATOM   503  C CG  B ASN A 1 92  ? 172.46800 323.08400 -15.41800 0.270 44.66137  ? 88  ASN F CG  1 
ATOM   504  O OD1 A ASN A 1 92  ? 174.69400 321.91600 -18.03900 0.730 46.57400  ? 88  ASN F OD1 1 
ATOM   505  O OD1 B ASN A 1 92  ? 172.21600 323.01700 -14.21400 0.270 45.03808  ? 88  ASN F OD1 1 
ATOM   506  N ND2 A ASN A 1 92  ? 173.38300 323.74400 -18.12400 0.730 45.59453  ? 88  ASN F ND2 1 
ATOM   507  N ND2 B ASN A 1 92  ? 171.56100 323.45300 -16.31500 0.270 45.52960  ? 88  ASN F ND2 1 
ATOM   508  N N   . ALA A 1 93  ? 173.56700 321.19900 -13.09800 1.000 41.97866  ? 89  ALA F N   1 
ATOM   509  C CA  . ALA A 1 93  ? 173.68300 321.22800 -11.64600 1.000 42.95947  ? 89  ALA F CA  1 
ATOM   510  C C   . ALA A 1 93  ? 174.78700 320.29700 -11.15200 1.000 48.66306  ? 89  ALA F C   1 
ATOM   511  O O   . ALA A 1 93  ? 175.56600 320.66300 -10.25400 1.000 43.70818  ? 89  ALA F O   1 
ATOM   512  C CB  . ALA A 1 93  ? 172.35200 320.84600 -11.00300 1.000 37.93311  ? 89  ALA F CB  1 
ATOM   513  N N   . VAL A 1 94  ? 174.94400 319.13200 -11.79100 1.000 48.10586  ? 90  VAL F N   1 
ATOM   514  C CA  . VAL A 1 94  ? 176.01000 318.22300 -11.36000 1.000 46.06544  ? 90  VAL F CA  1 
ATOM   515  C C   . VAL A 1 94  ? 177.39100 318.77500 -11.71100 1.000 45.85607  ? 90  VAL F C   1 
ATOM   516  O O   . VAL A 1 94  ? 178.32200 318.71400 -10.89100 1.000 45.15548  ? 90  VAL F O   1 
ATOM   517  C CB  . VAL A 1 94  ? 175.79700 316.81600 -11.94600 1.000 48.73881  ? 90  VAL F CB  1 
ATOM   518  C CG1 . VAL A 1 94  ? 176.99800 315.92500 -11.61400 1.000 42.02233  ? 90  VAL F CG1 1 
ATOM   519  C CG2 . VAL A 1 94  ? 174.47700 316.20200 -11.43200 1.000 38.39745  ? 90  VAL F CG2 1 
ATOM   520  N N   . THR A 1 95  ? 177.55000 319.35400 -12.90400 1.000 45.39570  ? 91  THR F N   1 
ATOM   521  C CA  . THR A 1 95  ? 178.87200 319.88600 -13.23200 1.000 51.62582  ? 91  THR F CA  1 
ATOM   522  C C   . THR A 1 95  ? 179.19600 321.12300 -12.39100 1.000 55.30412  ? 91  THR F C   1 
ATOM   523  O O   . THR A 1 95  ? 180.36000 321.34400 -12.03800 1.000 58.48434  ? 91  THR F O   1 
ATOM   524  C CB  . THR A 1 95  ? 178.97100 320.22300 -14.71800 1.000 47.39823  ? 91  THR F CB  1 
ATOM   525  O OG1 . THR A 1 95  ? 178.02100 321.23400 -15.04200 1.000 61.90807  ? 91  THR F OG1 1 
ATOM   526  C CG2 . THR A 1 95  ? 178.64100 319.00700 -15.55000 1.000 44.76888  ? 91  THR F CG2 1 
ATOM   527  N N   . ASP A 1 96  ? 178.18400 321.91000 -12.01800 1.000 50.10784  ? 92  ASP F N   1 
ATOM   528  C CA  . ASP A 1 96  ? 178.41900 323.05900 -11.15500 1.000 43.89068  ? 92  ASP F CA  1 
ATOM   529  C C   . ASP A 1 96  ? 178.87300 322.61000 -9.77100  1.000 50.80073  ? 92  ASP F C   1 
ATOM   530  O O   . ASP A 1 96  ? 179.78500 323.20700 -9.17500  1.000 53.73752  ? 92  ASP F O   1 
ATOM   531  C CB  . ASP A 1 96  ? 177.15400 323.92000 -11.07800 1.000 52.79968  ? 92  ASP F CB  1 
ATOM   532  C CG  . ASP A 1 96  ? 176.93800 324.76200 -12.34600 1.000 60.24416  ? 92  ASP F CG  1 
ATOM   533  O OD1 . ASP A 1 96  ? 177.93700 325.09300 -13.02400 1.000 67.49330  ? 92  ASP F OD1 1 
ATOM   534  O OD2 . ASP A 1 96  ? 175.77200 325.09400 -12.67000 1.000 62.05076  ? 92  ASP F OD2 1 
ATOM   535  N N   . LEU A 1 97  ? 178.28600 321.52900 -9.25800  1.000 43.03620  ? 93  LEU F N   1 
ATOM   536  C CA  . LEU A 1 97  ? 178.75400 321.02000 -7.97400  1.000 47.58720  ? 93  LEU F CA  1 
ATOM   537  C C   . LEU A 1 97  ? 180.16000 320.44500 -8.10200  1.000 51.06470  ? 93  LEU F C   1 
ATOM   538  O O   . LEU A 1 97  ? 180.97300 320.54900 -7.16400  1.000 51.01683  ? 93  LEU F O   1 
ATOM   539  C CB  . LEU A 1 97  ? 177.78100 319.95000 -7.49500  1.000 44.01315  ? 93  LEU F CB  1 
ATOM   540  C CG  . LEU A 1 97  ? 176.41400 320.46400 -7.03300  1.000 50.81093  ? 93  LEU F CG  1 
ATOM   541  C CD1 . LEU A 1 97  ? 175.53500 319.29500 -6.58900  1.000 50.98437  ? 93  LEU F CD1 1 
ATOM   542  C CD2 . LEU A 1 97  ? 176.56700 321.46400 -5.90000  1.000 41.31287  ? 93  LEU F CD2 1 
ATOM   543  N N   . GLN A 1 98  ? 180.52100 320.02600 -9.31300  1.000 46.99444  ? 94  GLN F N   1 
ATOM   544  C CA  . GLN A 1 98  ? 181.84500 319.46000 -9.53900  1.000 54.31094  ? 94  GLN F CA  1 
ATOM   545  C C   . GLN A 1 98  ? 182.87100 320.57900 -9.54000  1.000 47.38529  ? 94  GLN F C   1 
ATOM   546  O O   . GLN A 1 98  ? 183.95500 320.44200 -8.96000  1.000 46.70356  ? 94  GLN F O   1 
ATOM   547  C CB  . GLN A 1 98  ? 181.87200 318.62900 -10.83300 1.000 46.64703  ? 94  GLN F CB  1 
ATOM   548  C CG  . GLN A 1 98  ? 181.14800 317.26400 -10.67300 1.000 50.57602  ? 94  GLN F CG  1 
ATOM   549  C CD  . GLN A 1 98  ? 181.08800 316.43000 -11.95200 1.000 56.18826  ? 94  GLN F CD  1 
ATOM   550  O OE1 . GLN A 1 98  ? 181.16000 316.95600 -13.06400 1.000 53.80865  ? 94  GLN F OE1 1 
ATOM   551  N NE2 . GLN A 1 98  ? 180.95700 315.11600 -11.79000 1.000 59.80577  ? 94  GLN F NE2 1 
ATOM   552  N N   . LEU A 1 99  ? 182.54900 321.69100 -10.18400 1.000 50.87559  ? 95  LEU F N   1 
ATOM   553  C CA  . LEU A 1 99  ? 183.49400 322.78700 -10.11400 1.000 56.13822  ? 95  LEU F CA  1 
ATOM   554  C C   . LEU A 1 99  ? 183.52900 323.38900 -8.71700  1.000 56.32218  ? 95  LEU F C   1 
ATOM   555  O O   . LEU A 1 99  ? 184.51200 324.05000 -8.37700  1.000 62.52701  ? 95  LEU F O   1 
ATOM   556  C CB  . LEU A 1 99  ? 183.11500 323.87400 -11.11200 1.000 44.78823  ? 95  LEU F CB  1 
ATOM   557  C CG  . LEU A 1 99  ? 182.87600 323.37000 -12.53200 1.000 55.17949  ? 95  LEU F CG  1 
ATOM   558  C CD1 . LEU A 1 99  ? 182.47600 324.52600 -13.45500 1.000 64.45250  ? 95  LEU F CD1 1 
ATOM   559  C CD2 . LEU A 1 99  ? 184.11200 322.64400 -13.05500 1.000 57.73934  ? 95  LEU F CD2 1 
ATOM   560  N N   . LEU A 1 100 ? 182.51300 323.14700 -7.87700  1.000 52.22454  ? 96  LEU F N   1 
ATOM   561  C CA  . LEU A 1 100 ? 182.66200 323.61800 -6.50300  1.000 51.20110  ? 96  LEU F CA  1 
ATOM   562  C C   . LEU A 1 100 ? 183.66300 322.75600 -5.73100  1.000 57.96099  ? 96  LEU F C   1 
ATOM   563  O O   . LEU A 1 100 ? 184.38100 323.27000 -4.86800  1.000 55.71536  ? 96  LEU F O   1 
ATOM   564  C CB  . LEU A 1 100 ? 181.32000 323.66700 -5.77700  1.000 56.31747  ? 96  LEU F CB  1 
ATOM   565  C CG  . LEU A 1 100 ? 181.34200 324.11000 -4.31300  1.000 43.73190  ? 96  LEU F CG  1 
ATOM   566  C CD1 . LEU A 1 100 ? 181.85900 325.53900 -4.15900  1.000 51.15248  ? 96  LEU F CD1 1 
ATOM   567  C CD2 . LEU A 1 100 ? 179.94200 324.02900 -3.81500  1.000 46.30904  ? 96  LEU F CD2 1 
ATOM   568  N N   . MET A 1 101 ? 183.76900 321.45600 -6.04700  1.000 57.02046  ? 97  MET F N   1 
ATOM   569  C CA  . MET A 1 101 ? 184.74700 320.65500 -5.29300  1.000 59.15019  ? 97  MET F CA  1 
ATOM   570  C C   . MET A 1 101 ? 186.14000 320.66700 -5.89900  1.000 65.46526  ? 97  MET F C   1 
ATOM   571  O O   . MET A 1 101 ? 187.10600 320.36600 -5.18600  1.000 63.96877  ? 97  MET F O   1 
ATOM   572  C CB  . MET A 1 101 ? 184.34500 319.17300 -5.14600  1.000 56.22704  ? 97  MET F CB  1 
ATOM   573  C CG  . MET A 1 101 ? 183.53700 318.78600 -3.93500  1.000 61.68942  ? 97  MET F CG  1 
ATOM   574  S SD  . MET A 1 101 ? 182.47000 320.05000 -3.30700  1.000 63.23455  ? 97  MET F SD  1 
ATOM   575  C CE  . MET A 1 101 ? 181.18100 319.99800 -4.55200  1.000 61.13446  ? 97  MET F CE  1 
ATOM   576  N N   . GLN A 1 102 ? 186.27400 321.00600 -7.17900  1.000 65.08999  ? 98  GLN F N   1 
ATOM   577  C CA  . GLN A 1 102 ? 187.60600 321.22100 -7.73700  1.000 67.37000  ? 98  GLN F CA  1 
ATOM   578  C C   . GLN A 1 102 ? 188.32900 322.39800 -7.09200  1.000 69.18673  ? 98  GLN F C   1 
ATOM   579  O O   . GLN A 1 102 ? 189.51500 322.29600 -6.75700  1.000 73.51787  ? 98  GLN F O   1 
ATOM   580  C CB  . GLN A 1 102 ? 187.53000 321.41600 -9.24800  1.000 64.95472  ? 98  GLN F CB  1 
ATOM   581  C CG  . GLN A 1 102 ? 187.48200 320.11600 -10.02400 1.000 70.52542  ? 98  GLN F CG  1 
ATOM   582  C CD  . GLN A 1 102 ? 187.75600 320.33000 -11.49600 1.000 82.34581  ? 98  GLN F CD  1 
ATOM   583  O OE1 . GLN A 1 102 ? 187.92800 321.46800 -11.94600 1.000 75.08246  ? 98  GLN F OE1 1 
ATOM   584  N NE2 . GLN A 1 102 ? 187.83600 319.23500 -12.25100 1.000 91.52685  ? 98  GLN F NE2 1 
ATOM   585  N N   . SER A 1 103 ? 187.62700 323.50200 -6.86100  1.000 63.51594  ? 99  SER F N   1 
ATOM   586  C CA  . SER A 1 103 ? 188.22000 324.68100 -6.23800  1.000 67.34284  ? 99  SER F CA  1 
ATOM   587  C C   . SER A 1 103 ? 187.26300 325.25000 -5.21000  1.000 71.13796  ? 99  SER F C   1 
ATOM   588  O O   . SER A 1 103 ? 186.25200 325.86200 -5.57500  1.000 67.25422  ? 99  SER F O   1 
ATOM   589  C CB  . SER A 1 103 ? 188.54900 325.74700 -7.28900  1.000 76.29812  ? 99  SER F CB  1 
ATOM   590  O OG  . SER A 1 103 ? 187.36300 326.24400 -7.90400  1.000 74.60486  ? 99  SER F OG  1 
ATOM   591  N N   . THR A 1 104 ? 187.60400 325.09700 -3.92900  1.000 73.54561  ? 100 THR F N   1 
ATOM   592  C CA  . THR A 1 104 ? 186.71400 325.58400 -2.88900  1.000 79.39607  ? 100 THR F CA  1 
ATOM   593  C C   . THR A 1 104 ? 187.33600 326.82100 -2.26100  1.000 73.03284  ? 100 THR F C   1 
ATOM   594  O O   . THR A 1 104 ? 188.44000 326.76100 -1.69000  1.000 68.76638  ? 100 THR F O   1 
ATOM   595  C CB  . THR A 1 104 ? 186.48200 324.51300 -1.81100  1.000 84.60508  ? 100 THR F CB  1 
ATOM   596  O OG1 . THR A 1 104 ? 185.87100 323.34500 -2.38200  1.000 77.01864  ? 100 THR F OG1 1 
ATOM   597  C CG2 . THR A 1 104 ? 185.59000 325.06400 -0.68100  1.000 76.37411  ? 100 THR F CG2 1 
ATOM   598  N N   . PRO A 1 105 ? 186.66600 327.96500 -2.39200  1.000 72.05045  ? 101 PRO F N   1 
ATOM   599  C CA  . PRO A 1 105 ? 187.18800 329.20000 -1.79800  1.000 65.82266  ? 101 PRO F CA  1 
ATOM   600  C C   . PRO A 1 105 ? 187.16200 329.10800 -0.27900  1.000 65.78062  ? 101 PRO F C   1 
ATOM   601  O O   . PRO A 1 105 ? 186.24600 328.52900 0.31000   1.000 68.79283  ? 101 PRO F O   1 
ATOM   602  C CB  . PRO A 1 105 ? 186.24100 330.29200 -2.33100  1.000 60.23625  ? 101 PRO F CB  1 
ATOM   603  C CG  . PRO A 1 105 ? 185.55500 329.67200 -3.54600  1.000 59.59778  ? 101 PRO F CG  1 
ATOM   604  C CD  . PRO A 1 105 ? 185.46100 328.19900 -3.21500  1.000 70.11413  ? 101 PRO F CD  1 
ATOM   605  N N   . ALA A 1 106 ? 188.19500 329.65700 0.35300   1.000 59.75356  ? 102 ALA F N   1 
ATOM   606  C CA  . ALA A 1 106 ? 188.24200 329.65800 1.80400   1.000 60.60106  ? 102 ALA F CA  1 
ATOM   607  C C   . ALA A 1 106 ? 187.13000 330.54300 2.34200   1.000 63.95224  ? 102 ALA F C   1 
ATOM   608  O O   . ALA A 1 106 ? 186.70500 331.51200 1.70400   1.000 67.09759  ? 102 ALA F O   1 
ATOM   609  C CB  . ALA A 1 106 ? 189.59300 330.16400 2.31800   1.000 53.00279  ? 102 ALA F CB  1 
ATOM   610  N N   . THR A 1 107 ? 186.60400 330.15800 3.49500   1.000 62.92362  ? 103 THR F N   1 
ATOM   611  C CA  . THR A 1 107 ? 185.52800 330.90300 4.11200   1.000 55.42780  ? 103 THR F CA  1 
ATOM   612  C C   . THR A 1 107 ? 185.97700 331.40300 5.48200   1.000 54.89310  ? 103 THR F C   1 
ATOM   613  O O   . THR A 1 107 ? 186.97200 330.93300 6.05300   1.000 61.70749  ? 103 THR F O   1 
ATOM   614  C CB  . THR A 1 107 ? 184.27000 330.02000 4.23400   1.000 61.36576  ? 103 THR F CB  1 
ATOM   615  O OG1 . THR A 1 107 ? 183.25400 330.70300 4.98000   1.000 57.98680  ? 103 THR F OG1 1 
ATOM   616  C CG2 . THR A 1 107 ? 184.60600 328.67500 4.91500   1.000 48.81741  ? 103 THR F CG2 1 
ATOM   617  N N   . GLY A 1 108 ? 185.28300 332.43400 5.95900   1.000 57.29998  ? 143 GLY F N   1 
ATOM   618  C CA  . GLY A 1 108 ? 185.47200 332.98600 7.29000   1.000 54.55555  ? 143 GLY F CA  1 
ATOM   619  C C   . GLY A 1 108 ? 184.95400 332.10500 8.41200   1.000 55.72576  ? 143 GLY F C   1 
ATOM   620  O O   . GLY A 1 108 ? 185.14300 332.44200 9.58600   1.000 56.85817  ? 143 GLY F O   1 
ATOM   621  N N   . SER A 1 109 ? 184.35900 330.95900 8.06600   1.000 47.81084  ? 144 SER F N   1 
ATOM   622  C CA  . SER A 1 109 ? 183.79700 329.98900 8.99900   1.000 49.03689  ? 144 SER F CA  1 
ATOM   623  C C   . SER A 1 109 ? 184.73300 328.83600 9.33700   1.000 39.83691  ? 144 SER F C   1 
ATOM   624  O O   . SER A 1 109 ? 184.34300 327.95700 10.11500  1.000 32.98803  ? 144 SER F O   1 
ATOM   625  C CB  . SER A 1 109 ? 182.50100 329.41000 8.42200   1.000 41.11452  ? 144 SER F CB  1 
ATOM   626  O OG  . SER A 1 109 ? 181.59200 330.43400 8.05800   1.000 52.11762  ? 144 SER F OG  1 
ATOM   627  N N   . GLY A 1 110 ? 185.98600 328.87000 8.88400   1.000 37.29471  ? 145 GLY F N   1 
ATOM   628  C CA  . GLY A 1 110 ? 186.85700 327.73100 9.13800   1.000 32.69124  ? 145 GLY F CA  1 
ATOM   629  C C   . GLY A 1 110 ? 187.08000 327.44500 10.61700  1.000 33.25306  ? 145 GLY F C   1 
ATOM   630  O O   . GLY A 1 110 ? 187.18300 326.27600 11.00800  1.000 32.92680  ? 145 GLY F O   1 
ATOM   631  N N   . SER A 1 111 ? 187.01700 328.47700 11.47500  1.000 26.59881  ? 146 SER F N   1 
ATOM   632  C CA  . SER A 1 111 ? 187.19700 328.22300 12.90400  1.000 29.99294  ? 146 SER F CA  1 
ATOM   633  C C   . SER A 1 111 ? 185.98400 327.54100 13.53900  1.000 25.11201  ? 146 SER F C   1 
ATOM   634  O O   . SER A 1 111 ? 186.07600 327.12600 14.69400  1.000 23.87333  ? 146 SER F O   1 
ATOM   635  C CB  . SER A 1 111 ? 187.51300 329.50500 13.68200  1.000 21.26808  ? 146 SER F CB  1 
ATOM   636  O OG  . SER A 1 111 ? 186.48100 330.45100 13.51000  1.000 28.53336  ? 146 SER F OG  1 
ATOM   637  N N   . ALA A 1 112 ? 184.89900 327.31200 12.81100  1.000 23.10323  ? 147 ALA F N   1 
ATOM   638  C CA  . ALA A 1 112 ? 183.75600 326.66800 13.42600  1.000 24.51836  ? 147 ALA F CA  1 
ATOM   639  C C   . ALA A 1 112 ? 183.32300 325.38600 12.73600  1.000 23.72269  ? 147 ALA F C   1 
ATOM   640  O O   . ALA A 1 112 ? 182.48100 324.67800 13.29400  1.000 21.10858  ? 147 ALA F O   1 
ATOM   641  C CB  . ALA A 1 112 ? 182.54600 327.62100 13.40800  1.000 26.17261  ? 147 ALA F CB  1 
ATOM   642  N N   . ILE A 1 113 ? 183.95800 324.98600 11.63600  1.000 24.12081  ? 148 ILE F N   1 
ATOM   643  C CA  . ILE A 1 113 ? 183.52000 323.80900 10.88700  1.000 29.55924  ? 148 ILE F CA  1 
ATOM   644  C C   . ILE A 1 113 ? 184.55900 322.69100 10.81300  1.000 29.83689  ? 148 ILE F C   1 
ATOM   645  O O   . ILE A 1 113 ? 184.44300 321.82800 9.95500   1.000 37.36193  ? 148 ILE F O   1 
ATOM   646  C CB  . ILE A 1 113 ? 183.07500 324.20300 9.46800   1.000 28.89017  ? 148 ILE F CB  1 
ATOM   647  C CG1 . ILE A 1 113 ? 184.25100 324.82500 8.72100   1.000 30.27541  ? 148 ILE F CG1 1 
ATOM   648  C CG2 . ILE A 1 113 ? 181.90400 325.16200 9.52600   1.000 28.85202  ? 148 ILE F CG2 1 
ATOM   649  C CD1 . ILE A 1 113 ? 183.92200 325.23300 7.28400   1.000 37.12708  ? 148 ILE F CD1 1 
ATOM   650  N N   . CYS A 1 114 ? 185.59400 322.68600 11.64500  1.000 23.44675  ? 149 CYS F N   1 
ATOM   651  C CA  . CYS A 1 114 ? 186.55800 321.60100 11.52200  1.000 31.38578  ? 149 CYS F CA  1 
ATOM   652  C C   . CYS A 1 114 ? 185.92800 320.22200 11.74200  1.000 29.61252  ? 149 CYS F C   1 
ATOM   653  O O   . CYS A 1 114 ? 186.39500 319.24400 11.15700  1.000 29.44493  ? 149 CYS F O   1 
ATOM   654  C CB  . CYS A 1 114 ? 187.75300 321.84000 12.45800  1.000 32.48363  ? 149 CYS F CB  1 
ATOM   655  S SG  . CYS A 1 114 ? 187.41100 321.74700 14.26700  1.000 38.55076  ? 149 CYS F SG  1 
ATOM   656  N N   . SER A 1 115 ? 184.85800 320.10700 12.52300  1.000 26.98511  ? 150 SER F N   1 
ATOM   657  C CA  A SER A 1 115 ? 184.22000 318.80400 12.69800  0.310 31.67081  ? 150 SER F CA  1 
ATOM   658  C CA  B SER A 1 115 ? 184.24900 318.78900 12.68900  0.690 32.02460  ? 150 SER F CA  1 
ATOM   659  C C   . SER A 1 115 ? 183.61600 318.31000 11.38200  1.000 35.88842  ? 150 SER F C   1 
ATOM   660  O O   . SER A 1 115 ? 183.93100 317.20600 10.88900  1.000 36.42210  ? 150 SER F O   1 
ATOM   661  C CB  A SER A 1 115 ? 183.15400 318.90000 13.79300  0.310 30.50681  ? 150 SER F CB  1 
ATOM   662  C CB  B SER A 1 115 ? 183.21400 318.80500 13.81100  0.690 30.61101  ? 150 SER F CB  1 
ATOM   663  O OG  A SER A 1 115 ? 182.62900 317.62900 14.12900  0.310 35.41364  ? 150 SER F OG  1 
ATOM   664  O OG  B SER A 1 115 ? 182.45100 319.98800 13.78400  0.690 33.74821  ? 150 SER F OG  1 
ATOM   665  N N   . GLY A 1 116 ? 182.73800 319.12100 10.78600  1.000 29.43209  ? 151 GLY F N   1 
ATOM   666  C CA  . GLY A 1 116 ? 182.14200 318.69800 9.53600   1.000 32.96505  ? 151 GLY F CA  1 
ATOM   667  C C   . GLY A 1 116 ? 183.18100 318.53100 8.44500   1.000 34.47482  ? 151 GLY F C   1 
ATOM   668  O O   . GLY A 1 116 ? 183.06400 317.65200 7.59100   1.000 37.95571  ? 151 GLY F O   1 
ATOM   669  N N   . VAL A 1 117 ? 184.20600 319.38100 8.44600   1.000 33.89289  ? 152 VAL F N   1 
ATOM   670  C CA  . VAL A 1 117 ? 185.26200 319.23000 7.44900   1.000 32.83967  ? 152 VAL F CA  1 
ATOM   671  C C   . VAL A 1 117 ? 186.00900 317.91300 7.63400   1.000 42.03810  ? 152 VAL F C   1 
ATOM   672  O O   . VAL A 1 117 ? 186.45200 317.30000 6.65400   1.000 43.07683  ? 152 VAL F O   1 
ATOM   673  C CB  . VAL A 1 117 ? 186.22700 320.42200 7.51000   1.000 33.41117  ? 152 VAL F CB  1 
ATOM   674  C CG1 . VAL A 1 117 ? 187.50900 320.10300 6.75600   1.000 29.11930  ? 152 VAL F CG1 1 
ATOM   675  C CG2 . VAL A 1 117 ? 185.54300 321.68400 6.95700   1.000 35.05763  ? 152 VAL F CG2 1 
ATOM   676  N N   . ALA A 1 118 ? 186.20600 317.47200 8.89200   1.000 32.37720  ? 153 ALA F N   1 
ATOM   677  C CA  . ALA A 1 118 ? 186.86600 316.18500 9.07800   1.000 40.22376  ? 153 ALA F CA  1 
ATOM   678  C C   . ALA A 1 118 ? 186.01500 315.06700 8.51100   1.000 36.26228  ? 153 ALA F C   1 
ATOM   679  O O   . ALA A 1 118 ? 186.54100 314.13200 7.88900   1.000 41.37297  ? 153 ALA F O   1 
ATOM   680  C CB  . ALA A 1 118 ? 187.15800 315.93400 10.56000  1.000 27.69455  ? 153 ALA F CB  1 
ATOM   681  N N   . VAL A 1 119 ? 184.69700 315.24200 8.54100   1.000 35.24446  ? 154 VAL F N   1 
ATOM   682  C CA  . VAL A 1 119 ? 183.86500 314.18300 7.97800   1.000 39.10660  ? 154 VAL F CA  1 
ATOM   683  C C   . VAL A 1 119 ? 183.93800 314.22800 6.45700   1.000 42.84209  ? 154 VAL F C   1 
ATOM   684  O O   . VAL A 1 119 ? 184.02400 313.18400 5.78900   1.000 43.99704  ? 154 VAL F O   1 
ATOM   685  C CB  . VAL A 1 119 ? 182.41700 314.28700 8.48600   1.000 40.32632  ? 154 VAL F CB  1 
ATOM   686  C CG1 . VAL A 1 119 ? 181.58500 313.13000 7.96100   1.000 37.91284  ? 154 VAL F CG1 1 
ATOM   687  C CG2 . VAL A 1 119 ? 182.40900 314.22900 10.00800  1.000 32.40353  ? 154 VAL F CG2 1 
ATOM   688  N N   . CYS A 1 120 ? 183.99200 315.43400 5.88500   1.000 39.68669  ? 155 CYS F N   1 
ATOM   689  C CA  . CYS A 1 120 ? 184.10500 315.50100 4.43500   1.000 39.85779  ? 155 CYS F CA  1 
ATOM   690  C C   . CYS A 1 120 ? 185.44400 314.94400 3.95100   1.000 47.27705  ? 155 CYS F C   1 
ATOM   691  O O   . CYS A 1 120 ? 185.49500 314.28200 2.91300   1.000 51.10884  ? 155 CYS F O   1 
ATOM   692  C CB  . CYS A 1 120 ? 183.94300 316.95100 3.96100   1.000 39.58352  ? 155 CYS F CB  1 
ATOM   693  S SG  . CYS A 1 120 ? 182.23800 317.66200 3.99200   1.000 50.57959  ? 155 CYS F SG  1 
ATOM   694  N N   . LYS A 1 121 ? 186.53500 315.15400 4.70300   1.000 41.31437  ? 156 LYS F N   1 
ATOM   695  C CA  . LYS A 1 121 ? 187.82700 314.60300 4.27600   1.000 43.07074  ? 156 LYS F CA  1 
ATOM   696  C C   . LYS A 1 121 ? 187.86100 313.09200 4.40500   1.000 44.79333  ? 156 LYS F C   1 
ATOM   697  O O   . LYS A 1 121 ? 188.42500 312.41400 3.54700   1.000 43.90807  ? 156 LYS F O   1 
ATOM   698  C CB  . LYS A 1 121 ? 188.99700 315.22000 5.05400   1.000 45.89044  ? 156 LYS F CB  1 
ATOM   699  C CG  . LYS A 1 121 ? 189.57800 316.44600 4.35600   1.000 62.01117  ? 156 LYS F CG  1 
ATOM   700  C CD  . LYS A 1 121 ? 188.58100 317.59300 4.34400   1.000 60.45959  ? 156 LYS F CD  1 
ATOM   701  C CE  . LYS A 1 121 ? 189.13100 318.77600 3.56000   1.000 62.86155  ? 156 LYS F CE  1 
ATOM   702  N NZ  . LYS A 1 121 ? 188.03100 319.45100 2.77100   1.000 62.54818  ? 156 LYS F NZ  1 
ATOM   703  N N   . VAL A 1 122 ? 187.11900 312.54800 5.35800   1.000 40.03806  ? 157 VAL F N   1 
ATOM   704  C CA  . VAL A 1 122 ? 187.07500 311.10100 5.49800   1.000 43.36934  ? 157 VAL F CA  1 
ATOM   705  C C   . VAL A 1 122 ? 186.32900 310.51800 4.30700   1.000 51.30809  ? 157 VAL F C   1 
ATOM   706  O O   . VAL A 1 122 ? 186.68400 309.45700 3.77800   1.000 54.51044  ? 157 VAL F O   1 
ATOM   707  C CB  . VAL A 1 122 ? 186.46300 310.68500 6.85000   1.000 43.61017  ? 157 VAL F CB  1 
ATOM   708  C CG1 . VAL A 1 122 ? 184.96400 310.56000 6.76600   1.000 51.01582  ? 157 VAL F CG1 1 
ATOM   709  C CG2 . VAL A 1 122 ? 187.08000 309.38100 7.31900   1.000 51.63882  ? 157 VAL F CG2 1 
ATOM   710  N N   . LEU A 1 123 ? 185.30900 311.23400 3.84300   1.000 46.83370  ? 158 LEU F N   1 
ATOM   711  C CA  . LEU A 1 123 ? 184.50100 310.77100 2.72500   1.000 47.80736  ? 158 LEU F CA  1 
ATOM   712  C C   . LEU A 1 123 ? 185.31700 310.67600 1.43900   1.000 51.53712  ? 158 LEU F C   1 
ATOM   713  O O   . LEU A 1 123 ? 184.99400 309.86400 0.56800   1.000 51.99349  ? 158 LEU F O   1 
ATOM   714  C CB  . LEU A 1 123 ? 183.34300 311.74700 2.53900   1.000 41.54532  ? 158 LEU F CB  1 
ATOM   715  C CG  . LEU A 1 123 ? 182.14500 311.28200 3.34900   1.000 41.55407  ? 158 LEU F CG  1 
ATOM   716  C CD1 . LEU A 1 123 ? 180.95200 312.19200 3.11400   1.000 45.10755  ? 158 LEU F CD1 1 
ATOM   717  C CD2 . LEU A 1 123 ? 181.84300 309.82400 3.07500   1.000 52.50168  ? 158 LEU F CD2 1 
ATOM   718  N N   . HIS A 1 124 ? 186.36000 311.49100 1.28500   1.000 47.58947  ? 159 HIS F N   1 
ATOM   719  C CA  . HIS A 1 124 ? 187.17900 311.40100 0.08100   1.000 52.87963  ? 159 HIS F CA  1 
ATOM   720  C C   . HIS A 1 124 ? 188.01700 310.12900 0.01800   1.000 58.77419  ? 159 HIS F C   1 
ATOM   721  O O   . HIS A 1 124 ? 188.59900 309.85000 -1.03400  1.000 65.46807  ? 159 HIS F O   1 
ATOM   722  C CB  . HIS A 1 124 ? 188.13800 312.58000 -0.01800  1.000 46.84176  ? 159 HIS F CB  1 
ATOM   723  C CG  . HIS A 1 124 ? 187.51300 313.83500 -0.53000  1.000 52.97091  ? 159 HIS F CG  1 
ATOM   724  N ND1 . HIS A 1 124 ? 186.72000 314.64300 0.25800   1.000 50.66812  ? 159 HIS F ND1 1 
ATOM   725  C CD2 . HIS A 1 124 ? 187.61700 314.45800 -1.72700  1.000 49.73323  ? 159 HIS F CD2 1 
ATOM   726  C CE1 . HIS A 1 124 ? 186.34500 315.69900 -0.44000  1.000 51.14630  ? 159 HIS F CE1 1 
ATOM   727  N NE2 . HIS A 1 124 ? 186.87600 315.61200 -1.64700  1.000 51.15686  ? 159 HIS F NE2 1 
ATOM   728  N N   . LEU A 1 125 ? 188.13600 309.37200 1.10400   1.000 56.72946  ? 160 LEU F N   1 
ATOM   729  C CA  . LEU A 1 125 ? 188.86500 308.11900 1.00400   1.000 56.88340  ? 160 LEU F CA  1 
ATOM   730  C C   . LEU A 1 125 ? 188.10300 307.12000 0.14200   1.000 66.70334  ? 160 LEU F C   1 
ATOM   731  O O   . LEU A 1 125 ? 186.86700 307.08100 0.12900   1.000 69.97974  ? 160 LEU F O   1 
ATOM   732  C CB  . LEU A 1 125 ? 189.09800 307.51500 2.38700   1.000 55.05515  ? 160 LEU F CB  1 
ATOM   733  C CG  . LEU A 1 125 ? 189.86800 308.37400 3.39000   1.000 62.86527  ? 160 LEU F CG  1 
ATOM   734  C CD1 . LEU A 1 125 ? 190.03600 307.61800 4.70000   1.000 57.67793  ? 160 LEU F CD1 1 
ATOM   735  C CD2 . LEU A 1 125 ? 191.21500 308.83200 2.82900   1.000 60.35546  ? 160 LEU F CD2 1 
ATOM   736  N N   . GLU A 1 126 ? 188.86400 306.25300 -0.51800  1.000 67.61666  ? 161 GLU F N   1 
ATOM   737  C CA  . GLU A 1 126 ? 188.28000 305.25300 -1.39900  1.000 70.48565  ? 161 GLU F CA  1 
ATOM   738  C C   . GLU A 1 126 ? 187.58800 304.18300 -0.57600  1.000 64.61987  ? 161 GLU F C   1 
ATOM   739  O O   . GLU A 1 126 ? 188.15500 303.65500 0.38700   1.000 57.17863  ? 161 GLU F O   1 
ATOM   740  C CB  . GLU A 1 126 ? 189.33800 304.66900 -2.33300  1.000 75.71752  ? 161 GLU F CB  1 
ATOM   741  C CG  . GLU A 1 126 ? 189.72600 305.63700 -3.46400  1.000 84.11046  ? 161 GLU F CG  1 
ATOM   742  C CD  . GLU A 1 126 ? 190.64600 306.77100 -3.03200  1.000 92.43996  ? 161 GLU F CD  1 
ATOM   743  O OE1 . GLU A 1 126 ? 191.01400 306.83900 -1.83700  1.000 89.60133  ? 161 GLU F OE1 1 
ATOM   744  O OE2 . GLU A 1 126 ? 190.98200 307.61400 -3.89400  1.000 98.21097  ? 161 GLU F OE2 1 
ATOM   745  N N   . GLY A 1 127 ? 186.32500 303.93100 -0.91400  1.000 62.41947  ? 162 GLY F N   1 
ATOM   746  C CA  . GLY A 1 127 ? 185.51900 302.95300 -0.23200  1.000 57.64403  ? 162 GLY F CA  1 
ATOM   747  C C   . GLY A 1 127 ? 184.62800 303.53500 0.83900   1.000 64.60263  ? 162 GLY F C   1 
ATOM   748  O O   . GLY A 1 127 ? 183.71300 302.84200 1.30800   1.000 58.76295  ? 162 GLY F O   1 
ATOM   749  N N   . GLU A 1 128 ? 184.84400 304.79400 1.22900   1.000 62.41424  ? 163 GLU F N   1 
ATOM   750  C CA  . GLU A 1 128 ? 184.01800 305.33100 2.30000   1.000 64.36444  ? 163 GLU F CA  1 
ATOM   751  C C   . GLU A 1 128 ? 182.66700 305.77400 1.75500   1.000 63.23792  ? 163 GLU F C   1 
ATOM   752  O O   . GLU A 1 128 ? 181.61600 305.48000 2.35900   1.000 63.06595  ? 163 GLU F O   1 
ATOM   753  C CB  . GLU A 1 128 ? 184.73600 306.50600 2.97000   1.000 63.15914  ? 163 GLU F CB  1 
ATOM   754  C CG  . GLU A 1 128 ? 185.80300 306.10500 3.99400   1.000 68.76051  ? 163 GLU F CG  1 
ATOM   755  C CD  . GLU A 1 128 ? 185.22800 305.82600 5.37800   1.000 66.47424  ? 163 GLU F CD  1 
ATOM   756  O OE1 . GLU A 1 128 ? 184.26000 306.51100 5.77000   1.000 63.48195  ? 163 GLU F OE1 1 
ATOM   757  O OE2 . GLU A 1 128 ? 185.74800 304.92500 6.07800   1.000 72.09073  ? 163 GLU F OE2 1 
ATOM   758  N N   . VAL A 1 129 ? 182.66300 306.39000 0.56700   1.000 57.37567  ? 164 VAL F N   1 
ATOM   759  C CA  . VAL A 1 129 ? 181.37000 306.70700 -0.01600  1.000 58.75414  ? 164 VAL F CA  1 
ATOM   760  C C   . VAL A 1 129 ? 180.61900 305.43200 -0.37100  1.000 61.04815  ? 164 VAL F C   1 
ATOM   761  O O   . VAL A 1 129 ? 179.39900 305.36300 -0.19100  1.000 58.75491  ? 164 VAL F O   1 
ATOM   762  C CB  . VAL A 1 129 ? 181.58400 307.58500 -1.26400  1.000 60.99141  ? 164 VAL F CB  1 
ATOM   763  C CG1 . VAL A 1 129 ? 180.37700 307.51300 -2.19900  1.000 55.04138  ? 164 VAL F CG1 1 
ATOM   764  C CG2 . VAL A 1 129 ? 181.92300 309.01000 -0.87400  1.000 61.20123  ? 164 VAL F CG2 1 
ATOM   765  N N   . ASN A 1 130 ? 181.34600 304.35500 -0.70900  1.000 62.44707  ? 165 ASN F N   1 
ATOM   766  C CA  . ASN A 1 130 ? 180.70700 303.06900 -0.98100  1.000 58.58404  ? 165 ASN F CA  1 
ATOM   767  C C   . ASN A 1 130 ? 180.12300 302.50000 0.29000   1.000 57.92251  ? 165 ASN F C   1 
ATOM   768  O O   . ASN A 1 130 ? 179.10400 301.80100 0.27200   1.000 55.66285  ? 165 ASN F O   1 
ATOM   769  C CB  . ASN A 1 130 ? 181.69900 302.08500 -1.60300  1.000 70.80631  ? 165 ASN F CB  1 
ATOM   770  C CG  . ASN A 1 130 ? 182.37600 302.63900 -2.84800  1.000 77.08727  ? 165 ASN F CG  1 
ATOM   771  O OD1 . ASN A 1 130 ? 182.44300 303.85700 -3.05300  1.000 70.35818  ? 165 ASN F OD1 1 
ATOM   772  N ND2 . ASN A 1 130 ? 182.88500 301.73900 -3.68900  1.000 77.70168  ? 165 ASN F ND2 1 
ATOM   773  N N   . LYS A 1 131 ? 180.69500 302.89800 1.41200   1.000 58.07932  ? 166 LYS F N   1 
ATOM   774  C CA  . LYS A 1 131 ? 180.23500 302.39000 2.68400   1.000 53.89561  ? 166 LYS F CA  1 
ATOM   775  C C   . LYS A 1 131 ? 178.88300 303.01600 2.99900   1.000 57.80107  ? 166 LYS F C   1 
ATOM   776  O O   . LYS A 1 131 ? 177.91400 302.30200 3.30200   1.000 56.83146  ? 166 LYS F O   1 
ATOM   777  C CB  . LYS A 1 131 ? 181.31400 302.69400 3.72800   1.000 53.78409  ? 166 LYS F CB  1 
ATOM   778  C CG  . LYS A 1 131 ? 181.12300 302.25900 5.17600   1.000 54.77462  ? 166 LYS F CG  1 
ATOM   779  C CD  . LYS A 1 131 ? 182.34300 302.78500 5.95200   1.000 60.20152  ? 166 LYS F CD  1 
ATOM   780  C CE  . LYS A 1 131 ? 183.37100 301.69200 6.26400   1.000 64.68786  ? 166 LYS F CE  1 
ATOM   781  N NZ  . LYS A 1 131 ? 184.57800 302.20600 7.00700   1.000 60.42879  ? 166 LYS F NZ  1 
ATOM   782  N N   . ILE A 1 132 ? 178.79000 304.35400 2.94300   1.000 56.96048  ? 167 ILE F N   1 
ATOM   783  C CA  . ILE A 1 132 ? 177.46600 304.94300 3.18100   1.000 55.70820  ? 167 ILE F CA  1 
ATOM   784  C C   . ILE A 1 132 ? 176.46500 304.54200 2.10200   1.000 49.54963  ? 167 ILE F C   1 
ATOM   785  O O   . ILE A 1 132 ? 175.28300 304.32600 2.39200   1.000 49.44666  ? 167 ILE F O   1 
ATOM   786  C CB  . ILE A 1 132 ? 177.53300 306.48800 3.25400   1.000 56.35267  ? 167 ILE F CB  1 
ATOM   787  C CG1 . ILE A 1 132 ? 178.40700 306.97500 4.40500   1.000 53.77897  ? 167 ILE F CG1 1 
ATOM   788  C CG2 . ILE A 1 132 ? 176.13700 307.07000 3.41700   1.000 50.56843  ? 167 ILE F CG2 1 
ATOM   789  C CD1 . ILE A 1 132 ? 179.43700 307.94900 3.97600   1.000 50.73347  ? 167 ILE F CD1 1 
ATOM   790  N N   . LYS A 1 133 ? 176.93200 304.34400 0.86700   1.000 56.96485  ? 168 LYS F N   1 
ATOM   791  C CA  . LYS A 1 133 ? 176.05900 303.92700 -0.22800  1.000 56.36326  ? 168 LYS F CA  1 
ATOM   792  C C   . LYS A 1 133 ? 175.51800 302.52000 -0.03600  1.000 61.72950  ? 168 LYS F C   1 
ATOM   793  O O   . LYS A 1 133 ? 174.37200 302.23900 -0.40900  1.000 62.19230  ? 168 LYS F O   1 
ATOM   794  C CB  . LYS A 1 133 ? 176.85500 304.06300 -1.52700  1.000 59.37422  ? 168 LYS F CB  1 
ATOM   795  C CG  . LYS A 1 133 ? 176.11100 304.02800 -2.84500  1.000 61.99633  ? 168 LYS F CG  1 
ATOM   796  C CD  . LYS A 1 133 ? 177.14300 304.30900 -3.93000  1.000 59.72117  ? 168 LYS F CD  1 
ATOM   797  C CE  . LYS A 1 133 ? 176.55000 304.40300 -5.30700  1.000 63.07638  ? 168 LYS F CE  1 
ATOM   798  N NZ  . LYS A 1 133 ? 177.64600 304.71800 -6.25300  1.000 58.11000  ? 168 LYS F NZ  1 
ATOM   799  N N   . SER A 1 134 ? 176.26000 301.67700 0.67300   1.000 60.25369  ? 169 SER F N   1 
ATOM   800  C CA  . SER A 1 134 ? 175.80900 300.32100 0.93300   1.000 55.13802  ? 169 SER F CA  1 
ATOM   801  C C   . SER A 1 134 ? 174.88900 300.30100 2.13800   1.000 61.30953  ? 169 SER F C   1 
ATOM   802  O O   . SER A 1 134 ? 173.89300 299.56800 2.14800   1.000 57.88539  ? 169 SER F O   1 
ATOM   803  C CB  . SER A 1 134 ? 177.00700 299.39200 1.11800   1.000 61.34797  ? 169 SER F CB  1 
ATOM   804  O OG  . SER A 1 134 ? 176.71000 298.36000 2.03500   1.000 66.69274  ? 169 SER F OG  1 
ATOM   805  N N   . ALA A 1 135 ? 175.18700 301.12600 3.14700   1.000 55.86742  ? 170 ALA F N   1 
ATOM   806  C CA  . ALA A 1 135 ? 174.34200 301.12700 4.33500   1.000 54.72325  ? 170 ALA F CA  1 
ATOM   807  C C   . ALA A 1 135 ? 172.95700 301.66400 4.00400   1.000 54.51126  ? 170 ALA F C   1 
ATOM   808  O O   . ALA A 1 135 ? 171.97000 301.28300 4.65100   1.000 56.35858  ? 170 ALA F O   1 
ATOM   809  C CB  . ALA A 1 135 ? 174.98700 301.95200 5.44600   1.000 55.29369  ? 170 ALA F CB  1 
ATOM   810  N N   . LEU A 1 136 ? 172.87800 302.62700 3.08400   1.000 52.56375  ? 171 LEU F N   1 
ATOM   811  C CA  . LEU A 1 136 ? 171.60700 303.17900 2.63500   1.000 59.35962  ? 171 LEU F CA  1 
ATOM   812  C C   . LEU A 1 136 ? 171.06100 302.45900 1.40400   1.000 66.03459  ? 171 LEU F C   1 
ATOM   813  O O   . LEU A 1 136 ? 170.35200 303.07600 0.59300   1.000 62.24171  ? 171 LEU F O   1 
ATOM   814  C CB  . LEU A 1 136 ? 171.79000 304.66400 2.33300   1.000 55.58695  ? 171 LEU F CB  1 
ATOM   815  C CG  . LEU A 1 136 ? 172.15000 305.51600 3.54300   1.000 52.09000  ? 171 LEU F CG  1 
ATOM   816  C CD1 . LEU A 1 136 ? 172.31000 306.96900 3.12400   1.000 46.41947  ? 171 LEU F CD1 1 
ATOM   817  C CD2 . LEU A 1 136 ? 171.07700 305.35500 4.62700   1.000 46.91984  ? 171 LEU F CD2 1 
ATOM   818  N N   . LEU A 1 137 ? 171.29100 301.14500 1.29100   1.000 67.96044  ? 172 LEU F N   1 
ATOM   819  C CA  . LEU A 1 137 ? 170.81200 300.40500 0.12600   1.000 66.20926  ? 172 LEU F CA  1 
ATOM   820  C C   . LEU A 1 137 ? 169.34300 300.05800 0.26100   1.000 58.88444  ? 172 LEU F C   1 
ATOM   821  O O   . LEU A 1 137 ? 168.61700 300.05500 -0.73500  1.000 62.56694  ? 172 LEU F O   1 
ATOM   822  C CB  . LEU A 1 137 ? 171.65700 299.14900 -0.11200  1.000 63.00183  ? 172 LEU F CB  1 
ATOM   823  C CG  . LEU A 1 137 ? 172.53000 299.25500 -1.37600  1.000 70.47789  ? 172 LEU F CG  1 
ATOM   824  C CD1 . LEU A 1 137 ? 173.12900 297.90600 -1.81400  1.000 60.45681  ? 172 LEU F CD1 1 
ATOM   825  C CD2 . LEU A 1 137 ? 171.75600 299.91800 -2.52400  1.000 58.83765  ? 172 LEU F CD2 1 
ATOM   826  N N   . SER A 1 138 ? 168.87300 299.85100 1.48500   1.000 62.95541  ? 173 SER F N   1 
ATOM   827  C CA  . SER A 1 138 ? 167.50900 299.42500 1.71600   1.000 58.39503  ? 173 SER F CA  1 
ATOM   828  C C   . SER A 1 138 ? 166.70700 300.43500 2.51000   1.000 62.78397  ? 173 SER F C   1 
ATOM   829  O O   . SER A 1 138 ? 165.47400 300.36400 2.47700   1.000 63.91734  ? 173 SER F O   1 
ATOM   830  C CB  . SER A 1 138 ? 167.47700 298.07700 2.44900   1.000 70.15453  ? 173 SER F CB  1 
ATOM   831  O OG  . SER A 1 138 ? 166.13900 297.70700 2.73100   1.000 77.53969  ? 173 SER F OG  1 
ATOM   832  N N   . THR A 1 139 ? 167.35200 301.29000 3.30700   1.000 69.35427  ? 174 THR F N   1 
ATOM   833  C CA  . THR A 1 139 ? 166.62700 302.24500 4.13300   1.000 64.85659  ? 174 THR F CA  1 
ATOM   834  C C   . THR A 1 139 ? 167.15400 303.64200 3.80100   1.000 56.65738  ? 174 THR F C   1 
ATOM   835  O O   . THR A 1 139 ? 168.21400 303.79800 3.19000   1.000 62.33006  ? 174 THR F O   1 
ATOM   836  C CB  . THR A 1 139 ? 166.77100 301.90700 5.62700   1.000 57.73482  ? 174 THR F CB  1 
ATOM   837  O OG1 . THR A 1 139 ? 166.04200 302.85400 6.42300   1.000 61.68344  ? 174 THR F OG1 1 
ATOM   838  C CG2 . THR A 1 139 ? 168.23200 301.88200 6.03400   1.000 50.25705  ? 174 THR F CG2 1 
ATOM   839  N N   . ASN A 1 140 ? 166.41800 304.66900 4.22800   1.000 57.45492  ? 175 ASN F N   1 
ATOM   840  C CA  . ASN A 1 140 ? 166.84100 306.06000 4.03700   1.000 56.37216  ? 175 ASN F CA  1 
ATOM   841  C C   . ASN A 1 140 ? 167.83500 306.53400 5.08900   1.000 58.03357  ? 175 ASN F C   1 
ATOM   842  O O   . ASN A 1 140 ? 168.74100 307.31900 4.78600   1.000 63.90029  ? 175 ASN F O   1 
ATOM   843  C CB  . ASN A 1 140 ? 165.63900 306.98900 3.95200   1.000 62.68466  ? 175 ASN F CB  1 
ATOM   844  C CG  . ASN A 1 140 ? 164.73100 306.64500 2.78000   1.000 71.34811  ? 175 ASN F CG  1 
ATOM   845  O OD1 . ASN A 1 140 ? 165.19800 306.13500 1.75200   1.000 67.88108  ? 175 ASN F OD1 1 
ATOM   846  N ND2 . ASN A 1 140 ? 163.43600 306.92100 2.92200   1.000 67.56193  ? 175 ASN F ND2 1 
ATOM   847  N N   . LYS A 1 141 ? 167.65500 306.11700 6.33600   1.000 62.10742  ? 176 LYS F N   1 
ATOM   848  C CA  . LYS A 1 141 ? 168.51800 306.53700 7.43100   1.000 58.29030  ? 176 LYS F CA  1 
ATOM   849  C C   . LYS A 1 141 ? 169.32200 305.35800 7.95900   1.000 56.38047  ? 176 LYS F C   1 
ATOM   850  O O   . LYS A 1 141 ? 168.83000 304.23500 7.99000   1.000 55.72888  ? 176 LYS F O   1 
ATOM   851  C CB  . LYS A 1 141 ? 167.65700 307.15500 8.55100   1.000 54.74370  ? 176 LYS F CB  1 
ATOM   852  C CG  . LYS A 1 141 ? 166.81200 306.16700 9.30800   1.000 60.16415  ? 176 LYS F CG  1 
ATOM   853  C CD  . LYS A 1 141 ? 165.90400 306.85400 10.33700  1.000 53.93398  ? 176 LYS F CD  1 
ATOM   854  C CE  . LYS A 1 141 ? 165.01000 307.89700 9.67600   1.000 62.19037  ? 176 LYS F CE  1 
ATOM   855  N NZ  . LYS A 1 141 ? 164.08400 308.53500 10.66200  1.000 66.10604  ? 176 LYS F NZ  1 
ATOM   856  N N   . ALA A 1 142 ? 170.54900 305.62900 8.41100   1.000 55.00358  ? 177 ALA F N   1 
ATOM   857  C CA  . ALA A 1 142 ? 171.39200 304.55600 8.93800   1.000 54.80518  ? 177 ALA F CA  1 
ATOM   858  C C   . ALA A 1 142 ? 172.62600 305.13300 9.62600   1.000 57.26213  ? 177 ALA F C   1 
ATOM   859  O O   . ALA A 1 142 ? 173.19200 306.11900 9.15000   1.000 60.24228  ? 177 ALA F O   1 
ATOM   860  C CB  . ALA A 1 142 ? 171.82200 303.58400 7.83100   1.000 46.64038  ? 177 ALA F CB  1 
ATOM   861  N N   . VAL A 1 143 ? 173.05300 304.51000 10.72400  1.000 55.34986  ? 178 VAL F N   1 
ATOM   862  C CA  . VAL A 1 143 ? 174.28600 304.92700 11.39300  1.000 57.02156  ? 178 VAL F CA  1 
ATOM   863  C C   . VAL A 1 143 ? 175.46600 304.23800 10.71700  1.000 51.96743  ? 178 VAL F C   1 
ATOM   864  O O   . VAL A 1 143 ? 175.41100 303.04000 10.42600  1.000 64.18426  ? 178 VAL F O   1 
ATOM   865  C CB  . VAL A 1 143 ? 174.23600 304.57800 12.89000  1.000 53.50261  ? 178 VAL F CB  1 
ATOM   866  C CG1 . VAL A 1 143 ? 175.49400 305.06800 13.58800  1.000 48.06909  ? 178 VAL F CG1 1 
ATOM   867  C CG2 . VAL A 1 143 ? 172.98500 305.14900 13.53000  1.000 48.61215  ? 178 VAL F CG2 1 
ATOM   868  N N   . VAL A 1 144 ? 176.52900 304.99500 10.44800  1.000 52.07119  ? 179 VAL F N   1 
ATOM   869  C CA  . VAL A 1 144 ? 177.72100 304.50600 9.75700   1.000 51.67512  ? 179 VAL F CA  1 
ATOM   870  C C   . VAL A 1 144 ? 178.96700 304.91000 10.54100  1.000 58.55422  ? 179 VAL F C   1 
ATOM   871  O O   . VAL A 1 144 ? 179.12600 306.08700 10.90100  1.000 60.50877  ? 179 VAL F O   1 
ATOM   872  C CB  . VAL A 1 144 ? 177.79900 305.02200 8.30900   1.000 51.06884  ? 179 VAL F CB  1 
ATOM   873  C CG1 . VAL A 1 144 ? 179.07300 304.53300 7.63500   1.000 51.90934  ? 179 VAL F CG1 1 
ATOM   874  C CG2 . VAL A 1 144 ? 176.57800 304.57200 7.53900   1.000 49.43989  ? 179 VAL F CG2 1 
ATOM   875  N N   . SER A 1 145 ? 179.83000 303.93400 10.83500  1.000 54.74356  ? 180 SER F N   1 
ATOM   876  C CA  . SER A 1 145 ? 181.11700 304.20400 11.47500  1.000 57.43586  ? 180 SER F CA  1 
ATOM   877  C C   . SER A 1 145 ? 182.16300 304.43700 10.39200  1.000 56.27599  ? 180 SER F C   1 
ATOM   878  O O   . SER A 1 145 ? 182.55100 303.51100 9.67400   1.000 54.33348  ? 180 SER F O   1 
ATOM   879  C CB  . SER A 1 145 ? 181.53400 303.06000 12.39700  1.000 55.14441  ? 180 SER F CB  1 
ATOM   880  O OG  . SER A 1 145 ? 180.60600 302.89100 13.45700  1.000 66.32130  ? 180 SER F OG  1 
ATOM   881  N N   . LEU A 1 146 ? 182.62000 305.67700 10.27500  1.000 52.67035  ? 181 LEU F N   1 
ATOM   882  C CA  . LEU A 1 146 ? 183.58200 306.00300 9.24200   1.000 56.85983  ? 181 LEU F CA  1 
ATOM   883  C C   . LEU A 1 146 ? 184.97100 305.52100 9.66400   1.000 61.33312  ? 181 LEU F C   1 
ATOM   884  O O   . LEU A 1 146 ? 185.20600 305.14200 10.81600  1.000 60.32258  ? 181 LEU F O   1 
ATOM   885  C CB  . LEU A 1 146 ? 183.55500 307.50800 8.97800   1.000 54.17894  ? 181 LEU F CB  1 
ATOM   886  C CG  . LEU A 1 146 ? 182.14400 308.08800 8.82300   1.000 55.14260  ? 181 LEU F CG  1 
ATOM   887  C CD1 . LEU A 1 146 ? 182.16500 309.60900 8.85700   1.000 49.34353  ? 181 LEU F CD1 1 
ATOM   888  C CD2 . LEU A 1 146 ? 181.48300 307.58400 7.53900   1.000 48.45768  ? 181 LEU F CD2 1 
ATOM   889  N N   . SER A 1 147 ? 185.94500 305.68400 8.77000   1.000 59.84375  ? 182 SER F N   1 
ATOM   890  C CA  . SER A 1 147 ? 187.31000 305.25500 9.03800   1.000 57.14369  ? 182 SER F CA  1 
ATOM   891  C C   . SER A 1 147 ? 188.11800 306.31200 9.77900   1.000 58.14485  ? 182 SER F C   1 
ATOM   892  O O   . SER A 1 147 ? 189.35200 306.34700 9.67800   1.000 56.53222  ? 182 SER F O   1 
ATOM   893  C CB  . SER A 1 147 ? 187.98900 304.83200 7.73400   1.000 56.17098  ? 182 SER F CB  1 
ATOM   894  O OG  . SER A 1 147 ? 188.78800 305.86800 7.19700   1.000 64.28213  ? 182 SER F OG  1 
ATOM   895  N N   . ASN A 1 148 ? 187.45000 307.14700 10.57100  1.000 57.76224  ? 183 ASN F N   1 
ATOM   896  C CA  . ASN A 1 148 ? 188.15700 308.14700 11.35400  1.000 54.62952  ? 183 ASN F CA  1 
ATOM   897  C C   . ASN A 1 148 ? 187.60000 308.16500 12.76700  1.000 51.35408  ? 183 ASN F C   1 
ATOM   898  O O   . ASN A 1 148 ? 187.87300 309.11700 13.50900  1.000 49.87122  ? 183 ASN F O   1 
ATOM   899  C CB  . ASN A 1 148 ? 188.06600 309.56100 10.73900  1.000 54.51816  ? 183 ASN F CB  1 
ATOM   900  C CG  . ASN A 1 148 ? 186.65800 310.17100 10.83100  1.000 54.68661  ? 183 ASN F CG  1 
ATOM   901  O OD1 . ASN A 1 148 ? 185.64500 309.46400 10.81800  1.000 49.70794  ? 183 ASN F OD1 1 
ATOM   902  N ND2 . ASN A 1 148 ? 186.60100 311.49700 10.91100  1.000 47.69183  ? 183 ASN F ND2 1 
ATOM   903  N N   . GLY A 1 149 ? 186.82700 307.14000 13.14500  1.000 52.46637  ? 184 GLY F N   1 
ATOM   904  C CA  . GLY A 1 149 ? 186.26900 306.97100 14.47400  1.000 57.40020  ? 184 GLY F CA  1 
ATOM   905  C C   . GLY A 1 149 ? 184.98200 307.70700 14.76300  1.000 51.70214  ? 184 GLY F C   1 
ATOM   906  O O   . GLY A 1 149 ? 184.49100 307.63200 15.89700  1.000 45.29003  ? 184 GLY F O   1 
ATOM   907  N N   . VAL A 1 150 ? 184.38400 308.35200 13.76500  1.000 53.19968  ? 185 VAL F N   1 
ATOM   908  C CA  . VAL A 1 150 ? 183.16400 309.13500 13.93200  1.000 51.63470  ? 185 VAL F CA  1 
ATOM   909  C C   . VAL A 1 150 ? 181.98100 308.28400 13.48400  1.000 54.31634  ? 185 VAL F C   1 
ATOM   910  O O   . VAL A 1 150 ? 181.92800 307.83600 12.33100  1.000 54.11016  ? 185 VAL F O   1 
ATOM   911  C CB  . VAL A 1 150 ? 183.22900 310.45200 13.14100  1.000 51.19312  ? 185 VAL F CB  1 
ATOM   912  C CG1 . VAL A 1 150 ? 181.95400 311.27500 13.36200  1.000 48.89829  ? 185 VAL F CG1 1 
ATOM   913  C CG2 . VAL A 1 150 ? 184.49000 311.24500 13.48700  1.000 50.04722  ? 185 VAL F CG2 1 
ATOM   914  N N   . SER A 1 151 ? 181.06800 308.01600 14.41900  1.000 54.56527  ? 186 SER F N   1 
ATOM   915  C CA  . SER A 1 151 ? 179.81700 307.28800 14.17800  1.000 59.06341  ? 186 SER F CA  1 
ATOM   916  C C   . SER A 1 151 ? 178.68900 308.25400 13.80900  1.000 59.44674  ? 186 SER F C   1 
ATOM   917  O O   . SER A 1 151 ? 177.96500 308.75600 14.67500  1.000 63.92869  ? 186 SER F O   1 
ATOM   918  C CB  . SER A 1 151 ? 179.45100 306.45500 15.39600  1.000 56.00004  ? 186 SER F CB  1 
ATOM   919  O OG  . SER A 1 151 ? 178.31400 305.66200 15.13000  1.000 58.95468  ? 186 SER F OG  1 
ATOM   920  N N   . VAL A 1 152 ? 178.56800 308.55700 12.50100  1.000 52.74655  ? 187 VAL F N   1 
ATOM   921  C CA  . VAL A 1 152 ? 177.62700 309.56700 12.00500  1.000 50.42236  ? 187 VAL F CA  1 
ATOM   922  C C   . VAL A 1 152 ? 176.29800 308.94900 11.57700  1.000 54.44070  ? 187 VAL F C   1 
ATOM   923  O O   . VAL A 1 152 ? 176.18800 307.76700 11.24200  1.000 55.97032  ? 187 VAL F O   1 
ATOM   924  C CB  . VAL A 1 152 ? 178.22300 310.37600 10.84100  1.000 44.69384  ? 187 VAL F CB  1 
ATOM   925  C CG1 . VAL A 1 152 ? 179.61200 310.87400 11.19400  1.000 48.72584  ? 187 VAL F CG1 1 
ATOM   926  C CG2 . VAL A 1 152 ? 178.25300 309.52600 9.58400   1.000 54.99603  ? 187 VAL F CG2 1 
ATOM   927  N N   . LEU A 1 153 ? 175.25800 309.77400 11.57700  1.000 55.19718  ? 188 LEU F N   1 
ATOM   928  C CA  . LEU A 1 153 ? 173.93900 309.35300 11.13300  1.000 46.50233  ? 188 LEU F CA  1 
ATOM   929  C C   . LEU A 1 153 ? 173.79300 309.86900 9.70900   1.000 46.65354  ? 188 LEU F C   1 
ATOM   930  O O   . LEU A 1 153 ? 174.05800 311.05300 9.44800   1.000 48.18640  ? 188 LEU F O   1 
ATOM   931  C CB  . LEU A 1 153 ? 172.82300 309.94900 11.99300  1.000 42.79537  ? 188 LEU F CB  1 
ATOM   932  C CG  . LEU A 1 153 ? 172.23200 309.32400 13.25300  1.000 47.78699  ? 188 LEU F CG  1 
ATOM   933  C CD1 . LEU A 1 153 ? 171.55500 310.39600 14.09600  1.000 47.79443  ? 188 LEU F CD1 1 
ATOM   934  C CD2 . LEU A 1 153 ? 171.23900 308.23700 12.91000  1.000 49.24482  ? 188 LEU F CD2 1 
ATOM   935  N N   . THR A 1 154 ? 173.57700 308.95700 8.76800   1.000 48.40550  ? 189 THR F N   1 
ATOM   936  C CA  . THR A 1 154 ? 173.48200 309.28900 7.35700   1.000 47.81048  ? 189 THR F CA  1 
ATOM   937  C C   . THR A 1 154 ? 172.03000 309.15700 6.93800   1.000 48.70163  ? 189 THR F C   1 
ATOM   938  O O   . THR A 1 154 ? 171.26300 308.38400 7.52800   1.000 50.38584  ? 189 THR F O   1 
ATOM   939  C CB  . THR A 1 154 ? 174.37500 308.41000 6.48600   1.000 50.57680  ? 189 THR F CB  1 
ATOM   940  O OG1 . THR A 1 154 ? 173.97700 307.03700 6.63600   1.000 56.05340  ? 189 THR F OG1 1 
ATOM   941  C CG2 . THR A 1 154 ? 175.83100 308.58800 6.87000   1.000 50.40971  ? 189 THR F CG2 1 
ATOM   942  N N   . SER A 1 155 ? 171.66500 309.88800 5.89700   1.000 45.16716  ? 190 SER F N   1 
ATOM   943  C CA  . SER A 1 155 ? 170.34600 309.69400 5.32500   1.000 43.38437  ? 190 SER F CA  1 
ATOM   944  C C   . SER A 1 155 ? 170.40300 310.04300 3.84600   1.000 45.56180  ? 190 SER F C   1 
ATOM   945  O O   . SER A 1 155 ? 171.35900 310.65400 3.36600   1.000 43.70802  ? 190 SER F O   1 
ATOM   946  C CB  . SER A 1 155 ? 169.27300 310.50300 6.06900   1.000 41.75653  ? 190 SER F CB  1 
ATOM   947  O OG  . SER A 1 155 ? 169.44900 311.89700 5.90500   1.000 49.78721  ? 190 SER F OG  1 
ATOM   948  N N   . LYS A 1 156 ? 169.38100 309.60600 3.13200   1.000 44.27488  ? 191 LYS F N   1 
ATOM   949  C CA  . LYS A 1 156 ? 169.26600 309.73200 1.67800   1.000 50.54713  ? 191 LYS F CA  1 
ATOM   950  C C   . LYS A 1 156 ? 167.97900 310.50800 1.43400   1.000 43.07281  ? 191 LYS F C   1 
ATOM   951  O O   . LYS A 1 156 ? 166.88400 309.97800 1.63500   1.000 45.35631  ? 191 LYS F O   1 
ATOM   952  C CB  . LYS A 1 156 ? 169.30300 308.38700 0.95600   1.000 54.08186  ? 191 LYS F CB  1 
ATOM   953  C CG  . LYS A 1 156 ? 169.19600 308.51900 -0.57300  1.000 49.00118  ? 191 LYS F CG  1 
ATOM   954  C CD  . LYS A 1 156 ? 169.65800 307.24400 -1.29900  1.000 53.87934  ? 191 LYS F CD  1 
ATOM   955  C CE  . LYS A 1 156 ? 168.84700 306.01800 -0.93900  1.000 56.65303  ? 191 LYS F CE  1 
ATOM   956  N NZ  . LYS A 1 156 ? 169.40900 304.84300 -1.65200  1.000 58.91012  ? 191 LYS F NZ  1 
ATOM   957  N N   . VAL A 1 157 ? 168.10400 311.81300 1.20500   1.000 42.13114  ? 192 VAL F N   1 
ATOM   958  C CA  . VAL A 1 157 ? 166.90400 312.64400 1.13000   1.000 41.96016  ? 192 VAL F CA  1 
ATOM   959  C C   . VAL A 1 157 ? 166.28600 312.72800 -0.26400  1.000 42.77046  ? 192 VAL F C   1 
ATOM   960  O O   . VAL A 1 157 ? 165.14200 313.19400 -0.39200  1.000 37.51934  ? 192 VAL F O   1 
ATOM   961  C CB  . VAL A 1 157 ? 167.21700 314.05200 1.66300   1.000 35.85487  ? 192 VAL F CB  1 
ATOM   962  C CG1 . VAL A 1 157 ? 167.67600 313.94800 3.09800   1.000 36.72291  ? 192 VAL F CG1 1 
ATOM   963  C CG2 . VAL A 1 157 ? 168.32000 314.69700 0.82300   1.000 30.39061  ? 192 VAL F CG2 1 
ATOM   964  N N   . LEU A 1 158 ? 167.02200 312.35300 -1.31000  1.000 41.46194  ? 193 LEU F N   1 
ATOM   965  C CA  . LEU A 1 158 ? 166.52900 312.40600 -2.68000  1.000 40.38608  ? 193 LEU F CA  1 
ATOM   966  C C   . LEU A 1 158 ? 167.20600 311.28800 -3.47200  1.000 40.91811  ? 193 LEU F C   1 
ATOM   967  O O   . LEU A 1 158 ? 168.42200 311.10700 -3.36100  1.000 43.61163  ? 193 LEU F O   1 
ATOM   968  C CB  . LEU A 1 158 ? 166.79100 313.78300 -3.29300  1.000 32.14630  ? 193 LEU F CB  1 
ATOM   969  C CG  . LEU A 1 158 ? 166.24700 314.08500 -4.69600  1.000 40.95641  ? 193 LEU F CG  1 
ATOM   970  C CD1 . LEU A 1 158 ? 164.72400 314.02200 -4.76100  1.000 36.93417  ? 193 LEU F CD1 1 
ATOM   971  C CD2 . LEU A 1 158 ? 166.75100 315.45200 -5.15800  1.000 36.01154  ? 193 LEU F CD2 1 
ATOM   972  N N   . ASP A 1 159 ? 166.45000 310.58300 -4.32000  1.000 46.04583  ? 194 ASP F N   1 
ATOM   973  C CA  . ASP A 1 159 ? 167.01000 309.45800 -5.09000  1.000 42.71194  ? 194 ASP F CA  1 
ATOM   974  C C   . ASP A 1 159 ? 166.77500 309.72700 -6.56200  1.000 44.86526  ? 194 ASP F C   1 
ATOM   975  O O   . ASP A 1 159 ? 165.81600 309.23600 -7.16200  1.000 48.10590  ? 194 ASP F O   1 
ATOM   976  C CB  . ASP A 1 159 ? 166.39400 308.10600 -4.73600  1.000 44.56742  ? 194 ASP F CB  1 
ATOM   977  C CG  . ASP A 1 159 ? 167.23400 306.92500 -5.24800  1.000 53.44024  ? 194 ASP F CG  1 
ATOM   978  O OD1 . ASP A 1 159 ? 168.04100 307.11700 -6.18700  1.000 52.67159  ? 194 ASP F OD1 1 
ATOM   979  O OD2 . ASP A 1 159 ? 167.04700 305.79000 -4.75800  1.000 60.22243  ? 194 ASP F OD2 1 
ATOM   980  N N   . LEU A 1 160 ? 167.73000 310.40700 -7.15800  1.000 35.89649  ? 195 LEU F N   1 
ATOM   981  C CA  . LEU A 1 160 ? 167.66400 310.68600 -8.57000  1.000 40.67975  ? 195 LEU F CA  1 
ATOM   982  C C   . LEU A 1 160 ? 168.27900 309.57900 -9.41000  1.000 45.34743  ? 195 LEU F C   1 
ATOM   983  O O   . LEU A 1 160 ? 167.92900 309.46200 -10.58300 1.000 47.63709  ? 195 LEU F O   1 
ATOM   984  C CB  . LEU A 1 160 ? 168.34200 312.02400 -8.87300  1.000 36.13512  ? 195 LEU F CB  1 
ATOM   985  C CG  . LEU A 1 160 ? 167.56200 313.23700 -8.37200  1.000 38.46838  ? 195 LEU F CG  1 
ATOM   986  C CD1 . LEU A 1 160 ? 168.27600 314.53800 -8.74000  1.000 36.08437  ? 195 LEU F CD1 1 
ATOM   987  C CD2 . LEU A 1 160 ? 166.16100 313.21600 -8.93900  1.000 34.73284  ? 195 LEU F CD2 1 
ATOM   988  N N   . LYS A 1 161 ? 169.22900 308.79400 -8.88900  1.000 43.98663  ? 196 LYS F N   1 
ATOM   989  C CA  . LYS A 1 161 ? 169.74100 307.71900 -9.73100  1.000 52.57346  ? 196 LYS F CA  1 
ATOM   990  C C   . LYS A 1 161 ? 168.67600 306.68300 -10.04100 1.000 47.34704  ? 196 LYS F C   1 
ATOM   991  O O   . LYS A 1 161 ? 168.49400 306.30000 -11.20000 1.000 55.36374  ? 196 LYS F O   1 
ATOM   992  C CB  . LYS A 1 161 ? 170.89800 307.00700 -9.02800  1.000 47.86587  ? 196 LYS F CB  1 
ATOM   993  C CG  . LYS A 1 161 ? 171.49100 305.90000 -9.88900  1.000 52.79505  ? 196 LYS F CG  1 
ATOM   994  C CD  . LYS A 1 161 ? 172.72300 305.26000 -9.29700  1.000 59.81181  ? 196 LYS F CD  1 
ATOM   995  C CE  . LYS A 1 161 ? 172.93600 303.88600 -9.92700  1.000 65.88828  ? 196 LYS F CE  1 
ATOM   996  N NZ  . LYS A 1 161 ? 173.23500 303.99800 -11.39100 1.000 58.90184  ? 196 LYS F NZ  1 
ATOM   997  N N   . ASN A 1 162 ? 167.87900 306.32000 -9.04800  1.000 44.80996  ? 197 ASN F N   1 
ATOM   998  C CA  . ASN A 1 162 ? 166.81600 305.35400 -9.27500  1.000 49.60675  ? 197 ASN F CA  1 
ATOM   999  C C   . ASN A 1 162 ? 165.75300 305.92800 -10.19200 1.000 51.55888  ? 197 ASN F C   1 
ATOM   1000 O O   . ASN A 1 162 ? 165.31000 305.25900 -11.13300 1.000 48.33929  ? 197 ASN F O   1 
ATOM   1001 C CB  . ASN A 1 162 ? 166.24400 304.85500 -7.96000  1.000 53.40010  ? 197 ASN F CB  1 
ATOM   1002 C CG  . ASN A 1 162 ? 166.82300 303.50900 -7.58300  1.000 63.34706  ? 197 ASN F CG  1 
ATOM   1003 O OD1 . ASN A 1 162 ? 166.41800 302.47700 -8.11800  1.000 70.03267  ? 197 ASN F OD1 1 
ATOM   1004 N ND2 . ASN A 1 162 ? 167.81700 303.51700 -6.69800  1.000 57.05733  ? 197 ASN F ND2 1 
ATOM   1005 N N   . TYR A 1 163 ? 165.45800 307.21800 -10.03800 1.000 42.72477  ? 198 TYR F N   1 
ATOM   1006 C CA  . TYR A 1 163 ? 164.39600 307.80100 -10.83600 1.000 40.69794  ? 198 TYR F CA  1 
ATOM   1007 C C   . TYR A 1 163 ? 164.83500 308.00800 -12.26600 1.000 43.77311  ? 198 TYR F C   1 
ATOM   1008 O O   . TYR A 1 163 ? 164.09300 307.66300 -13.19000 1.000 43.32262  ? 198 TYR F O   1 
ATOM   1009 C CB  . TYR A 1 163 ? 163.99900 309.15400 -10.25300 1.000 36.07746  ? 198 TYR F CB  1 
ATOM   1010 C CG  . TYR A 1 163 ? 162.76100 309.73000 -10.87300 1.000 40.19937  ? 198 TYR F CG  1 
ATOM   1011 C CD1 . TYR A 1 163 ? 161.49500 309.41200 -10.41900 1.000 41.95103  ? 198 TYR F CD1 1 
ATOM   1012 C CD2 . TYR A 1 163 ? 162.87100 310.54700 -11.99300 1.000 35.06716  ? 198 TYR F CD2 1 
ATOM   1013 C CE1 . TYR A 1 163 ? 160.36900 309.94500 -11.02600 1.000 38.11202  ? 198 TYR F CE1 1 
ATOM   1014 C CE2 . TYR A 1 163 ? 161.75300 311.07000 -12.60800 1.000 37.16111  ? 198 TYR F CE2 1 
ATOM   1015 C CZ  . TYR A 1 163 ? 160.50900 310.76500 -12.12300 1.000 37.63460  ? 198 TYR F CZ  1 
ATOM   1016 O OH  . TYR A 1 163 ? 159.39800 311.29700 -12.73600 1.000 43.74107  ? 198 TYR F OH  1 
ATOM   1017 N N   . ILE A 1 164 ? 166.06600 308.46400 -12.47700 1.000 35.96593  ? 199 ILE F N   1 
ATOM   1018 C CA  . ILE A 1 164 ? 166.50800 308.72400 -13.83200 1.000 40.26933  ? 199 ILE F CA  1 
ATOM   1019 C C   . ILE A 1 164 ? 166.70200 307.40400 -14.55700 1.000 48.46625  ? 199 ILE F C   1 
ATOM   1020 O O   . ILE A 1 164 ? 166.33000 307.27200 -15.72600 1.000 45.12599  ? 199 ILE F O   1 
ATOM   1021 C CB  . ILE A 1 164 ? 167.75200 309.61700 -13.85200 1.000 41.77367  ? 199 ILE F CB  1 
ATOM   1022 C CG1 . ILE A 1 164 ? 167.36000 310.99300 -13.30900 1.000 43.12923  ? 199 ILE F CG1 1 
ATOM   1023 C CG2 . ILE A 1 164 ? 168.29900 309.74900 -15.27300 1.000 38.04998  ? 199 ILE F CG2 1 
ATOM   1024 C CD1 . ILE A 1 164 ? 168.49500 311.99100 -13.25300 1.000 35.25864  ? 199 ILE F CD1 1 
ATOM   1025 N N   . ASP A 1 165 ? 167.30500 306.41300 -13.88600 1.000 47.03025  ? 200 ASP F N   1 
ATOM   1026 C CA  . ASP A 1 165 ? 167.61000 305.14000 -14.52900 1.000 56.52485  ? 200 ASP F CA  1 
ATOM   1027 C C   . ASP A 1 165 ? 166.36900 304.27800 -14.74400 1.000 53.73738  ? 200 ASP F C   1 
ATOM   1028 O O   . ASP A 1 165 ? 166.37400 303.43300 -15.64000 1.000 53.59986  ? 200 ASP F O   1 
ATOM   1029 C CB  . ASP A 1 165 ? 168.67900 304.37900 -13.73800 1.000 51.55817  ? 200 ASP F CB  1 
ATOM   1030 C CG  . ASP A 1 165 ? 170.04700 305.07200 -13.77600 1.000 60.60671  ? 200 ASP F CG  1 
ATOM   1031 O OD1 . ASP A 1 165 ? 170.09500 306.28600 -14.05000 1.000 61.19766  ? 200 ASP F OD1 1 
ATOM   1032 O OD2 . ASP A 1 165 ? 171.07600 304.40700 -13.51200 1.000 59.33278  ? 200 ASP F OD2 1 
ATOM   1033 N N   . LYS A 1 166 ? 165.31000 304.46000 -13.96400 1.000 48.58707  ? 201 LYS F N   1 
ATOM   1034 C CA  . LYS A 1 166 ? 164.12800 303.63100 -14.14400 1.000 47.01700  ? 201 LYS F CA  1 
ATOM   1035 C C   . LYS A 1 166 ? 163.08300 304.29700 -15.04300 1.000 52.39659  ? 201 LYS F C   1 
ATOM   1036 O O   . LYS A 1 166 ? 162.45500 303.62400 -15.86200 1.000 60.06210  ? 201 LYS F O   1 
ATOM   1037 C CB  . LYS A 1 166 ? 163.52900 303.30900 -12.77800 1.000 54.36984  ? 201 LYS F CB  1 
ATOM   1038 C CG  . LYS A 1 166 ? 164.36200 302.29800 -11.99500 1.000 56.89149  ? 201 LYS F CG  1 
ATOM   1039 C CD  . LYS A 1 166 ? 163.70800 301.89800 -10.67800 1.000 62.89492  ? 201 LYS F CD  1 
ATOM   1040 C CE  . LYS A 1 166 ? 164.51200 300.80800 -9.98300  1.000 63.89682  ? 201 LYS F CE  1 
ATOM   1041 N NZ  . LYS A 1 166 ? 165.77200 300.50100 -10.72700 1.000 60.89304  ? 201 LYS F NZ  1 
ATOM   1042 N N   . GLN A 1 167 ? 162.88600 305.61300 -14.92000 1.000 53.06812  ? 202 GLN F N   1 
ATOM   1043 C CA  . GLN A 1 167 ? 161.82500 306.32900 -15.61600 1.000 46.85315  ? 202 GLN F CA  1 
ATOM   1044 C C   . GLN A 1 167 ? 162.26700 307.17300 -16.80200 1.000 51.93600  ? 202 GLN F C   1 
ATOM   1045 O O   . GLN A 1 167 ? 161.45200 307.43300 -17.69100 1.000 53.79698  ? 202 GLN F O   1 
ATOM   1046 C CB  . GLN A 1 167 ? 161.10100 307.24000 -14.63200 1.000 45.83683  ? 202 GLN F CB  1 
ATOM   1047 C CG  . GLN A 1 167 ? 160.95400 306.59500 -13.29600 1.000 50.12804  ? 202 GLN F CG  1 
ATOM   1048 C CD  . GLN A 1 167 ? 159.52000 306.50700 -12.89200 1.000 55.54953  ? 202 GLN F CD  1 
ATOM   1049 O OE1 . GLN A 1 167 ? 158.63800 306.37900 -13.74200 1.000 61.16864  ? 202 GLN F OE1 1 
ATOM   1050 N NE2 . GLN A 1 167 ? 159.26200 306.58900 -11.59000 1.000 65.06447  ? 202 GLN F NE2 1 
ATOM   1051 N N   . LEU A 1 168 ? 163.52500 307.57500 -16.85400 1.000 44.97497  ? 203 LEU F N   1 
ATOM   1052 C CA  . LEU A 1 168 ? 164.08400 308.48300 -17.85100 1.000 49.54245  ? 203 LEU F CA  1 
ATOM   1053 C C   . LEU A 1 168 ? 164.98400 307.78100 -18.85700 1.000 52.80932  ? 203 LEU F C   1 
ATOM   1054 O O   . LEU A 1 168 ? 164.97800 308.14600 -20.03200 1.000 53.21360  ? 203 LEU F O   1 
ATOM   1055 C CB  . LEU A 1 168 ? 164.80900 309.66100 -17.19000 1.000 45.44219  ? 203 LEU F CB  1 
ATOM   1056 C CG  . LEU A 1 168 ? 163.85900 310.50600 -16.33100 1.000 47.18501  ? 203 LEU F CG  1 
ATOM   1057 C CD1 . LEU A 1 168 ? 164.53000 311.80600 -15.86100 1.000 38.27629  ? 203 LEU F CD1 1 
ATOM   1058 C CD2 . LEU A 1 168 ? 162.49800 310.77000 -16.96700 1.000 36.79717  ? 203 LEU F CD2 1 
ATOM   1059 N N   . LEU A 1 169 ? 165.79800 306.83000 -18.41100 1.000 50.59399  ? 204 LEU F N   1 
ATOM   1060 C CA  . LEU A 1 169 ? 166.72600 306.13800 -19.29800 1.000 57.66931  ? 204 LEU F CA  1 
ATOM   1061 C C   . LEU A 1 169 ? 165.99300 305.42700 -20.42800 1.000 62.23619  ? 204 LEU F C   1 
ATOM   1062 O O   . LEU A 1 169 ? 166.43800 305.54500 -21.58000 1.000 58.90944  ? 204 LEU F O   1 
ATOM   1063 C CB  . LEU A 1 169 ? 167.54600 305.11000 -18.50800 1.000 63.54478  ? 204 LEU F CB  1 
ATOM   1064 C CG  . LEU A 1 169 ? 168.58900 305.41000 -17.43000 1.000 66.91134  ? 204 LEU F CG  1 
ATOM   1065 C CD1 . LEU A 1 169 ? 169.28100 304.09100 -17.00500 1.000 66.56467  ? 204 LEU F CD1 1 
ATOM   1066 C CD2 . LEU A 1 169 ? 169.59900 306.48900 -17.83500 1.000 65.54431  ? 204 LEU F CD2 1 
ATOM   1067 N N   . PRO A 1 170 ? 164.85200 304.76500 -20.20400 1.000 60.33153  ? 205 PRO F N   1 
ATOM   1068 C CA  . PRO A 1 170 ? 164.10000 304.18200 -21.33300 1.000 61.68763  ? 205 PRO F CA  1 
ATOM   1069 C C   . PRO A 1 170 ? 163.69000 305.21700 -22.37100 1.000 60.89050  ? 205 PRO F C   1 
ATOM   1070 O O   . PRO A 1 170 ? 163.28600 304.83100 -23.47600 1.000 68.89748  ? 205 PRO F O   1 
ATOM   1071 C CB  . PRO A 1 170 ? 162.86800 303.55400 -20.65800 1.000 59.62771  ? 205 PRO F CB  1 
ATOM   1072 C CG  . PRO A 1 170 ? 163.30100 303.31200 -19.23600 1.000 61.36430  ? 205 PRO F CG  1 
ATOM   1073 C CD  . PRO A 1 170 ? 164.21100 304.47300 -18.91100 1.000 56.25653  ? 205 PRO F CD  1 
ATOM   1074 N N   . ILE A 1 171 ? 163.77100 306.50500 -22.06000 1.000 62.36572  ? 206 ILE F N   1 
ATOM   1075 C CA  . ILE A 1 171 ? 163.41100 307.53100 -23.02800 1.000 64.74214  ? 206 ILE F CA  1 
ATOM   1076 C C   . ILE A 1 171 ? 164.59100 307.88800 -23.91900 1.000 69.67226  ? 206 ILE F C   1 
ATOM   1077 O O   . ILE A 1 171 ? 164.47400 307.82100 -25.14200 1.000 81.36882  ? 206 ILE F O   1 
ATOM   1078 C CB  . ILE A 1 171 ? 162.88300 308.78900 -22.30000 1.000 57.22183  ? 206 ILE F CB  1 
ATOM   1079 C CG1 . ILE A 1 171 ? 161.60400 308.47700 -21.52100 1.000 50.91075  ? 206 ILE F CG1 1 
ATOM   1080 C CG2 . ILE A 1 171 ? 162.71700 309.95400 -23.26900 1.000 45.28729  ? 206 ILE F CG2 1 
ATOM   1081 C CD1 . ILE A 1 171 ? 161.37400 309.38500 -20.33400 1.000 47.25899  ? 206 ILE F CD1 1 
ATOM   1082 N N   . VAL A 1 172 ? 165.76500 308.21000 -23.36600 1.000 71.09151  ? 207 VAL F N   1 
ATOM   1083 C CA  . VAL A 1 172 ? 166.89700 308.61000 -24.20600 1.000 74.32166  ? 207 VAL F CA  1 
ATOM   1084 C C   . VAL A 1 172 ? 167.81200 307.44900 -24.60700 1.000 76.98787  ? 207 VAL F C   1 
ATOM   1085 O O   . VAL A 1 172 ? 168.82600 307.68700 -25.27900 1.000 82.49849  ? 207 VAL F O   1 
ATOM   1086 C CB  . VAL A 1 172 ? 167.73600 309.69900 -23.50600 1.000 75.67810  ? 207 VAL F CB  1 
ATOM   1087 C CG1 . VAL A 1 172 ? 167.12100 311.08000 -23.71800 1.000 70.15476  ? 207 VAL F CG1 1 
ATOM   1088 C CG2 . VAL A 1 172 ? 167.84300 309.39100 -22.02200 1.000 66.60290  ? 207 VAL F CG2 1 
ATOM   1089 N N   . ASN A 1 173 ? 167.47300 306.20200 -24.25000 1.000 73.27876  ? 208 ASN F N   1 
ATOM   1090 C CA  . ASN A 1 173 ? 168.40700 305.07400 -24.33900 1.000 82.94664  ? 208 ASN F CA  1 
ATOM   1091 C C   . ASN A 1 173 ? 168.09800 304.07800 -25.45500 1.000 89.43244  ? 208 ASN F C   1 
ATOM   1092 O O   . ASN A 1 173 ? 167.88800 302.89100 -25.17900 1.000 86.58779  ? 208 ASN F O   1 
ATOM   1093 C CB  . ASN A 1 173 ? 168.44200 304.31200 -23.00600 1.000 79.12500  ? 208 ASN F CB  1 
ATOM   1094 C CG  . ASN A 1 173 ? 169.51000 304.84000 -22.04300 1.000 90.04545  ? 208 ASN F CG  1 
ATOM   1095 O OD1 . ASN A 1 173 ? 169.90400 306.00900 -22.10400 1.000 89.84676  ? 208 ASN F OD1 1 
ATOM   1096 N ND2 . ASN A 1 173 ? 169.95800 303.98100 -21.12800 1.000 85.17968  ? 208 ASN F ND2 1 
ATOM   1097 N N   . LYS A 1 174 ? 168.11300 304.53900 -26.70800 1.000 85.57832  ? 209 LYS F N   1 
ATOM   1098 C CA  . LYS A 1 174 ? 167.86900 303.72900 -27.90300 1.000 84.93469  ? 209 LYS F CA  1 
ATOM   1099 C C   . LYS A 1 174 ? 168.07700 304.57300 -29.14300 1.000 91.13915  ? 209 LYS F C   1 
ATOM   1100 O O   . LYS A 1 174 ? 168.55800 305.70800 -29.06300 1.000 91.97067  ? 209 LYS F O   1 
ATOM   1101 C CB  . LYS A 1 174 ? 166.45300 303.14000 -27.98200 1.000 85.22132  ? 209 LYS F CB  1 
ATOM   1102 C CG  . LYS A 1 174 ? 166.04000 302.13200 -26.94800 1.000 85.39449  ? 209 LYS F CG  1 
ATOM   1103 C CD  . LYS A 1 174 ? 164.65000 301.60900 -27.26800 1.000 70.11981  ? 209 LYS F CD  1 
ATOM   1104 C CE  . LYS A 1 174 ? 163.62100 302.71300 -27.10500 1.000 72.47753  ? 209 LYS F CE  1 
ATOM   1105 N NZ  . LYS A 1 174 ? 163.32500 302.95200 -25.66600 1.000 68.12884  ? 209 LYS F NZ  1 
ATOM   1106 N N   . GLN A 1 175 ? 167.74000 303.99500 -30.29600 1.000 97.52731  ? 210 GLN F N   1 
ATOM   1107 C CA  . GLN A 1 175 ? 167.79800 304.73300 -31.55300 1.000 99.68172  ? 210 GLN F CA  1 
ATOM   1108 C C   . GLN A 1 175 ? 166.71000 305.80600 -31.57400 1.000 101.65330 ? 210 GLN F C   1 
ATOM   1109 O O   . GLN A 1 175 ? 166.99100 306.97400 -31.87300 1.000 103.04626 ? 210 GLN F O   1 
ATOM   1110 C CB  . GLN A 1 175 ? 167.69900 303.77200 -32.74100 1.000 99.46351  ? 210 GLN F CB  1 
ATOM   1111 C CG  . GLN A 1 175 ? 168.51900 302.49400 -32.53100 1.000 102.75233 ? 210 GLN F CG  1 
ATOM   1112 C CD  . GLN A 1 175 ? 168.68300 301.66000 -33.79000 1.000 104.77233 ? 210 GLN F CD  1 
ATOM   1113 O OE1 . GLN A 1 175 ? 168.52100 302.15600 -34.90600 1.000 106.57895 ? 210 GLN F OE1 1 
ATOM   1114 N NE2 . GLN A 1 175 ? 169.02600 300.38600 -33.61300 1.000 95.66540  ? 210 GLN F NE2 1 
ATOM   1115 N N   . SER A 1 176 ? 165.45000 305.43400 -31.30200 1.000 103.22032 ? 211 SER F N   1 
ATOM   1116 C CA  . SER A 1 176 ? 164.40700 306.44400 -31.14200 1.000 98.31608  ? 211 SER F CA  1 
ATOM   1117 C C   . SER A 1 176 ? 163.86100 306.44800 -29.71000 1.000 88.62039  ? 211 SER F C   1 
ATOM   1118 O O   . SER A 1 176 ? 163.68600 305.39700 -29.07900 1.000 87.59886  ? 211 SER F O   1 
ATOM   1119 C CB  . SER A 1 176 ? 163.27400 306.21100 -32.15500 1.000 93.73945  ? 211 SER F CB  1 
ATOM   1120 O OG  . SER A 1 176 ? 162.71900 304.91400 -32.02000 1.000 89.98547  ? 211 SER F OG  1 
ATOM   1121 N N   . CYS A 1 177 ? 163.59700 307.65900 -29.22200 1.000 87.10566  ? 212 CYS F N   1 
ATOM   1122 C CA  . CYS A 1 177 ? 163.15500 307.92500 -27.85200 1.000 92.50551  ? 212 CYS F CA  1 
ATOM   1123 C C   . CYS A 1 177 ? 161.75000 307.40500 -27.51500 1.000 77.74755  ? 212 CYS F C   1 
ATOM   1124 O O   . CYS A 1 177 ? 160.81500 307.55400 -28.30400 1.000 79.30140  ? 212 CYS F O   1 
ATOM   1125 C CB  . CYS A 1 177 ? 163.26800 309.43400 -27.58800 1.000 86.46311  ? 212 CYS F CB  1 
ATOM   1126 S SG  . CYS A 1 177 ? 164.90400 309.86800 -26.84600 1.000 118.33294 ? 212 CYS F SG  1 
ATOM   1127 N N   . SER A 1 178 ? 161.59100 306.79500 -26.33300 1.000 65.55957  ? 213 SER F N   1 
ATOM   1128 C CA  . SER A 1 178 ? 160.23000 306.51500 -25.88700 1.000 56.15211  ? 213 SER F CA  1 
ATOM   1129 C C   . SER A 1 178 ? 159.53400 307.77900 -25.33800 1.000 53.05295  ? 213 SER F C   1 
ATOM   1130 O O   . SER A 1 178 ? 160.17300 308.72200 -24.87800 1.000 49.98765  ? 213 SER F O   1 
ATOM   1131 C CB  . SER A 1 178 ? 160.25400 305.44400 -24.80000 1.000 53.47030  ? 213 SER F CB  1 
ATOM   1132 O OG  . SER A 1 178 ? 158.94200 305.08700 -24.41500 1.000 64.35881  ? 213 SER F OG  1 
ATOM   1133 N N   . ILE A 1 179 ? 158.20400 307.76100 -25.39200 1.000 47.15404  ? 214 ILE F N   1 
ATOM   1134 C CA  . ILE A 1 179 ? 157.36400 308.90500 -25.01200 1.000 40.54369  ? 214 ILE F CA  1 
ATOM   1135 C C   . ILE A 1 179 ? 156.99300 308.80200 -23.53500 1.000 44.15198  ? 214 ILE F C   1 
ATOM   1136 O O   . ILE A 1 179 ? 156.24300 307.89300 -23.15900 1.000 42.48557  ? 214 ILE F O   1 
ATOM   1137 C CB  . ILE A 1 179 ? 156.11800 309.05700 -25.88800 1.000 45.99445  ? 214 ILE F CB  1 
ATOM   1138 C CG1 . ILE A 1 179 ? 156.52600 309.17300 -27.35500 1.000 43.61230  ? 214 ILE F CG1 1 
ATOM   1139 C CG2 . ILE A 1 179 ? 155.45000 310.39000 -25.53800 1.000 30.88332  ? 214 ILE F CG2 1 
ATOM   1140 C CD1 . ILE A 1 179 ? 157.52100 310.26300 -27.60600 1.000 42.64222  ? 214 ILE F CD1 1 
ATOM   1141 N N   . PRO A 1 180 ? 157.41300 309.73200 -22.68400 1.000 37.59999  ? 215 PRO F N   1 
ATOM   1142 C CA  . PRO A 1 180 ? 156.97600 309.68900 -21.28300 1.000 36.31906  ? 215 PRO F CA  1 
ATOM   1143 C C   . PRO A 1 180 ? 155.60000 310.30700 -21.08100 1.000 31.39613  ? 215 PRO F C   1 
ATOM   1144 O O   . PRO A 1 180 ? 155.12500 311.11200 -21.88300 1.000 33.26682  ? 215 PRO F O   1 
ATOM   1145 C CB  . PRO A 1 180 ? 158.02800 310.54800 -20.57200 1.000 35.16560  ? 215 PRO F CB  1 
ATOM   1146 C CG  . PRO A 1 180 ? 158.37700 311.58400 -21.59900 1.000 35.26902  ? 215 PRO F CG  1 
ATOM   1147 C CD  . PRO A 1 180 ? 158.26100 310.90500 -22.95800 1.000 35.44087  ? 215 PRO F CD  1 
ATOM   1148 N N   . ASN A 1 181 ? 154.89500 309.81400 -20.06600 1.000 30.21953  ? 216 ASN F N   1 
ATOM   1149 C CA  . ASN A 1 181 ? 153.58100 310.37700 -19.77900 1.000 33.57546  ? 216 ASN F CA  1 
ATOM   1150 C C   . ASN A 1 181 ? 153.79300 311.74000 -19.10800 1.000 33.28734  ? 216 ASN F C   1 
ATOM   1151 O O   . ASN A 1 181 ? 154.85200 312.01500 -18.53100 1.000 35.01705  ? 216 ASN F O   1 
ATOM   1152 C CB  . ASN A 1 181 ? 152.76700 309.43500 -18.87800 1.000 35.29159  ? 216 ASN F CB  1 
ATOM   1153 C CG  . ASN A 1 181 ? 153.55400 308.93600 -17.65300 1.000 38.78567  ? 216 ASN F CG  1 
ATOM   1154 O OD1 . ASN A 1 181 ? 153.65600 309.63200 -16.66000 1.000 41.26649  ? 216 ASN F OD1 1 
ATOM   1155 N ND2 . ASN A 1 181 ? 154.19600 307.79400 -17.77600 1.000 45.50870  ? 216 ASN F ND2 1 
ATOM   1156 N N   . ILE A 1 182 ? 152.77500 312.60200 -19.18100 1.000 26.32826  ? 217 ILE F N   1 
ATOM   1157 C CA  . ILE A 1 182 ? 152.90500 313.94800 -18.62500 1.000 31.66675  ? 217 ILE F CA  1 
ATOM   1158 C C   . ILE A 1 182 ? 153.08500 313.99700 -17.10600 1.000 32.97611  ? 217 ILE F C   1 
ATOM   1159 O O   . ILE A 1 182 ? 153.74200 314.92200 -16.58900 1.000 37.18824  ? 217 ILE F O   1 
ATOM   1160 C CB  . ILE A 1 182 ? 151.66100 314.76300 -19.06000 1.000 30.42572  ? 217 ILE F CB  1 
ATOM   1161 C CG1 . ILE A 1 182 ? 151.91300 316.28000 -18.97200 1.000 22.34741  ? 217 ILE F CG1 1 
ATOM   1162 C CG2 . ILE A 1 182 ? 150.38600 314.32600 -18.29600 1.000 26.17502  ? 217 ILE F CG2 1 
ATOM   1163 C CD1 . ILE A 1 182 ? 153.04600 316.77400 -19.88600 1.000 28.87049  ? 217 ILE F CD1 1 
ATOM   1164 N N   . GLU A 1 183 ? 152.64100 312.96800 -16.38500 1.000 27.77322  ? 218 GLU F N   1 
ATOM   1165 C CA  . GLU A 1 183 ? 152.89500 312.91400 -14.94800 1.000 32.92037  ? 218 GLU F CA  1 
ATOM   1166 C C   . GLU A 1 183 ? 154.38500 312.79300 -14.65000 1.000 36.76192  ? 218 GLU F C   1 
ATOM   1167 O O   . GLU A 1 183 ? 154.87400 313.37000 -13.67600 1.000 29.16002  ? 218 GLU F O   1 
ATOM   1168 C CB  . GLU A 1 183 ? 152.15100 311.75900 -14.28600 1.000 31.52427  ? 218 GLU F CB  1 
ATOM   1169 C CG  . GLU A 1 183 ? 150.63400 311.88100 -14.26400 1.000 38.54176  ? 218 GLU F CG  1 
ATOM   1170 C CD  . GLU A 1 183 ? 149.99200 311.38100 -15.56100 1.000 36.91248  ? 218 GLU F CD  1 
ATOM   1171 O OE1 . GLU A 1 183 ? 150.74200 310.93600 -16.45900 1.000 31.54678  ? 218 GLU F OE1 1 
ATOM   1172 O OE2 . GLU A 1 183 ? 148.74100 311.39600 -15.65600 1.000 40.89002  ? 218 GLU F OE2 1 
ATOM   1173 N N   . THR A 1 184 ? 155.12400 312.05200 -15.47700 1.000 29.44065  ? 219 THR F N   1 
ATOM   1174 C CA  . THR A 1 184 ? 156.56000 311.93200 -15.26400 1.000 32.99343  ? 219 THR F CA  1 
ATOM   1175 C C   . THR A 1 184 ? 157.24400 313.26900 -15.48400 1.000 36.09946  ? 219 THR F C   1 
ATOM   1176 O O   . THR A 1 184 ? 158.17000 313.61800 -14.75200 1.000 35.87834  ? 219 THR F O   1 
ATOM   1177 C CB  . THR A 1 184 ? 157.14700 310.84200 -16.16200 1.000 31.09792  ? 219 THR F CB  1 
ATOM   1178 O OG1 . THR A 1 184 ? 156.58900 309.58300 -15.78700 1.000 33.35456  ? 219 THR F OG1 1 
ATOM   1179 C CG2 . THR A 1 184 ? 158.65500 310.79600 -16.06600 1.000 34.22353  ? 219 THR F CG2 1 
ATOM   1180 N N   . VAL A 1 185 ? 156.81000 314.03200 -16.48200 1.000 33.55923  ? 220 VAL F N   1 
ATOM   1181 C CA  . VAL A 1 185 ? 157.41200 315.34100 -16.71000 1.000 27.57476  ? 220 VAL F CA  1 
ATOM   1182 C C   . VAL A 1 185 ? 157.22100 316.22800 -15.48100 1.000 33.90392  ? 220 VAL F C   1 
ATOM   1183 O O   . VAL A 1 185 ? 158.16800 316.87600 -15.00000 1.000 32.17865  ? 220 VAL F O   1 
ATOM   1184 C CB  . VAL A 1 185 ? 156.79300 315.98800 -17.96100 1.000 29.48366  ? 220 VAL F CB  1 
ATOM   1185 C CG1 . VAL A 1 185 ? 157.33900 317.37900 -18.16100 1.000 32.16532  ? 220 VAL F CG1 1 
ATOM   1186 C CG2 . VAL A 1 185 ? 157.03800 315.10300 -19.20800 1.000 31.16662  ? 220 VAL F CG2 1 
ATOM   1187 N N   . ILE A 1 186 ? 156.03400 316.18100 -14.87400 1.000 31.66750  ? 221 ILE F N   1 
ATOM   1188 C CA  . ILE A 1 186 ? 155.83000 317.05500 -13.72400 1.000 34.40400  ? 221 ILE F CA  1 
ATOM   1189 C C   . ILE A 1 186 ? 156.59600 316.53800 -12.51100 1.000 38.63459  ? 221 ILE F C   1 
ATOM   1190 O O   . ILE A 1 186 ? 157.25500 317.31500 -11.79600 1.000 33.66383  ? 221 ILE F O   1 
ATOM   1191 C CB  . ILE A 1 186 ? 154.33000 317.14800 -13.42500 1.000 32.96400  ? 221 ILE F CB  1 
ATOM   1192 C CG1 . ILE A 1 186 ? 153.62500 317.87100 -14.57200 1.000 33.24348  ? 221 ILE F CG1 1 
ATOM   1193 C CG2 . ILE A 1 186 ? 154.10600 317.89400 -12.09100 1.000 25.82977  ? 221 ILE F CG2 1 
ATOM   1194 C CD1 . ILE A 1 186 ? 152.15300 317.98600 -14.36200 1.000 31.77471  ? 221 ILE F CD1 1 
ATOM   1195 N N   . GLU A 1 187 ? 156.57400 315.22000 -12.28700 1.000 32.60028  ? 222 GLU F N   1 
ATOM   1196 C CA  . GLU A 1 187 ? 157.28800 314.67800 -11.14100 1.000 35.84484  ? 222 GLU F CA  1 
ATOM   1197 C C   . GLU A 1 187 ? 158.77900 314.89400 -11.24200 1.000 35.70491  ? 222 GLU F C   1 
ATOM   1198 O O   . GLU A 1 187 ? 159.43400 315.16300 -10.22900 1.000 36.81368  ? 222 GLU F O   1 
ATOM   1199 C CB  . GLU A 1 187 ? 157.10300 313.16700 -11.02300 1.000 38.06600  ? 222 GLU F CB  1 
ATOM   1200 C CG  . GLU A 1 187 ? 157.42000 312.64800 -9.61600  1.000 45.58298  ? 222 GLU F CG  1 
ATOM   1201 C CD  . GLU A 1 187 ? 157.06200 311.18900 -9.40600  1.000 52.89021  ? 222 GLU F CD  1 
ATOM   1202 O OE1 . GLU A 1 187 ? 156.87800 310.46800 -10.41000 1.000 54.46903  ? 222 GLU F OE1 1 
ATOM   1203 O OE2 . GLU A 1 187 ? 156.97000 310.76400 -8.23400  1.000 62.13571  ? 222 GLU F OE2 1 
ATOM   1204 N N   . PHE A 1 188 ? 159.32000 314.88900 -12.45200 1.000 30.76759  ? 223 PHE F N   1 
ATOM   1205 C CA  . PHE A 1 188 ? 160.75000 315.09300 -12.54200 1.000 33.45668  ? 223 PHE F CA  1 
ATOM   1206 C C   . PHE A 1 188 ? 161.12400 316.53800 -12.36000 1.000 34.12532  ? 223 PHE F C   1 
ATOM   1207 O O   . PHE A 1 188 ? 162.15700 316.80600 -11.75100 1.000 31.14021  ? 223 PHE F O   1 
ATOM   1208 C CB  . PHE A 1 188 ? 161.29300 314.58000 -13.87200 1.000 29.70857  ? 223 PHE F CB  1 
ATOM   1209 C CG  . PHE A 1 188 ? 162.78300 314.67700 -13.98200 1.000 32.11441  ? 223 PHE F CG  1 
ATOM   1210 C CD1 . PHE A 1 188 ? 163.59200 314.21400 -12.95700 1.000 33.43979  ? 223 PHE F CD1 1 
ATOM   1211 C CD2 . PHE A 1 188 ? 163.37800 315.17900 -15.12000 1.000 31.67377  ? 223 PHE F CD2 1 
ATOM   1212 C CE1 . PHE A 1 188 ? 164.97500 314.29100 -13.05300 1.000 34.81330  ? 223 PHE F CE1 1 
ATOM   1213 C CE2 . PHE A 1 188 ? 164.76400 315.25400 -15.23000 1.000 35.69037  ? 223 PHE F CE2 1 
ATOM   1214 C CZ  . PHE A 1 188 ? 165.56000 314.80600 -14.19400 1.000 35.44024  ? 223 PHE F CZ  1 
ATOM   1215 N N   . GLN A 1 189 ? 160.28100 317.48100 -12.78800 1.000 31.92798  ? 224 GLN F N   1 
ATOM   1216 C CA  . GLN A 1 189 ? 160.64000 318.86200 -12.49200 1.000 34.18850  ? 224 GLN F CA  1 
ATOM   1217 C C   . GLN A 1 189 ? 160.56400 319.14200 -10.99800 1.000 38.99915  ? 224 GLN F C   1 
ATOM   1218 O O   . GLN A 1 189 ? 161.45800 319.81000 -10.45500 1.000 35.03530  ? 224 GLN F O   1 
ATOM   1219 C CB  . GLN A 1 189 ? 159.71800 319.81000 -13.24300 1.000 32.69133  ? 224 GLN F CB  1 
ATOM   1220 C CG  . GLN A 1 189 ? 159.92700 319.73400 -14.73100 1.000 50.71978  ? 224 GLN F CG  1 
ATOM   1221 C CD  . GLN A 1 189 ? 158.95500 320.58700 -15.50500 1.000 55.61683  ? 224 GLN F CD  1 
ATOM   1222 O OE1 . GLN A 1 189 ? 158.02400 321.17000 -14.93600 1.000 55.59750  ? 224 GLN F OE1 1 
ATOM   1223 N NE2 . GLN A 1 189 ? 159.18500 320.69400 -16.81100 1.000 53.91565  ? 224 GLN F NE2 1 
ATOM   1224 N N   . GLN A 1 190 ? 159.65200 318.45600 -10.29600 1.000 36.60331  ? 225 GLN F N   1 
ATOM   1225 C CA  . GLN A 1 190 ? 159.53300 318.63100 -8.84600  1.000 36.81943  ? 225 GLN F CA  1 
ATOM   1226 C C   . GLN A 1 190 ? 160.73300 318.03800 -8.12100  1.000 41.55064  ? 225 GLN F C   1 
ATOM   1227 O O   . GLN A 1 190 ? 161.28500 318.65600 -7.20300  1.000 43.15204  ? 225 GLN F O   1 
ATOM   1228 C CB  . GLN A 1 190 ? 158.25900 317.96500 -8.32800  1.000 42.51006  ? 225 GLN F CB  1 
ATOM   1229 C CG  . GLN A 1 190 ? 156.97200 318.49500 -8.89500  1.000 45.61929  ? 225 GLN F CG  1 
ATOM   1230 C CD  . GLN A 1 190 ? 156.69200 319.90700 -8.45900  1.000 58.79840  ? 225 GLN F CD  1 
ATOM   1231 O OE1 . GLN A 1 190 ? 156.73900 320.83500 -9.26900  1.000 66.86844  ? 225 GLN F OE1 1 
ATOM   1232 N NE2 . GLN A 1 190 ? 156.37400 320.08200 -7.17300  1.000 61.31094  ? 225 GLN F NE2 1 
ATOM   1233 N N   . LYS A 1 191 ? 161.15500 316.84600 -8.52800  1.000 35.29641  ? 226 LYS F N   1 
ATOM   1234 C CA  . LYS A 1 191 ? 162.29000 316.20600 -7.88500  1.000 32.07829  ? 226 LYS F CA  1 
ATOM   1235 C C   . LYS A 1 191 ? 163.58900 316.93700 -8.21200  1.000 38.90546  ? 226 LYS F C   1 
ATOM   1236 O O   . LYS A 1 191 ? 164.43000 317.14900 -7.33100  1.000 40.33447  ? 226 LYS F O   1 
ATOM   1237 C CB  . LYS A 1 191 ? 162.37800 314.75600 -8.35700  1.000 35.18244  ? 226 LYS F CB  1 
ATOM   1238 C CG  . LYS A 1 191 ? 161.39900 313.77300 -7.73900  1.000 37.76301  ? 226 LYS F CG  1 
ATOM   1239 C CD  . LYS A 1 191 ? 161.89900 312.34200 -7.96700  1.000 43.93253  ? 226 LYS F CD  1 
ATOM   1240 C CE  . LYS A 1 191 ? 162.14500 311.58800 -6.68700  1.000 49.09381  ? 226 LYS F CE  1 
ATOM   1241 N NZ  . LYS A 1 191 ? 160.89800 310.87600 -6.29600  1.000 56.79379  ? 226 LYS F NZ  1 
ATOM   1242 N N   . ASN A 1 192 ? 163.76500 317.36400 -9.45900  1.000 32.23137  ? 227 ASN F N   1 
ATOM   1243 C CA  . ASN A 1 192 ? 165.01800 318.00000 -9.82000  1.000 38.53435  ? 227 ASN F CA  1 
ATOM   1244 C C   . ASN A 1 192 ? 165.13300 319.38400 -9.18000  1.000 42.55404  ? 227 ASN F C   1 
ATOM   1245 O O   . ASN A 1 192 ? 166.25300 319.90500 -9.01400  1.000 35.69472  ? 227 ASN F O   1 
ATOM   1246 C CB  . ASN A 1 192 ? 165.09000 318.11000 -11.34800 1.000 33.10198  ? 227 ASN F CB  1 
ATOM   1247 C CG  . ASN A 1 192 ? 166.46900 318.46100 -11.85400 1.000 34.31781  ? 227 ASN F CG  1 
ATOM   1248 O OD1 . ASN A 1 192 ? 167.45000 318.07000 -11.24800 1.000 40.11512  ? 227 ASN F OD1 1 
ATOM   1249 N ND2 . ASN A 1 192 ? 166.55300 319.20500 -12.95400 1.000 35.33894  ? 227 ASN F ND2 1 
ATOM   1250 N N   . ASN A 1 193 ? 164.00200 319.94200 -8.73200  1.000 38.56435  ? 228 ASN F N   1 
ATOM   1251 C CA  . ASN A 1 193 ? 164.01500 321.29900 -8.20700  1.000 38.89600  ? 228 ASN F CA  1 
ATOM   1252 C C   . ASN A 1 193 ? 164.89600 321.38200 -6.95900  1.000 38.64267  ? 228 ASN F C   1 
ATOM   1253 O O   . ASN A 1 193 ? 165.63800 322.35300 -6.78700  1.000 40.82343  ? 228 ASN F O   1 
ATOM   1254 C CB  . ASN A 1 193 ? 162.59600 321.73500 -7.84000  1.000 35.15425  ? 228 ASN F CB  1 
ATOM   1255 C CG  . ASN A 1 193 ? 162.54700 323.14900 -7.31000  1.000 35.40186  ? 228 ASN F CG  1 
ATOM   1256 O OD1 . ASN A 1 193 ? 163.14900 324.04900 -7.87900  1.000 40.39445  ? 228 ASN F OD1 1 
ATOM   1257 N ND2 . ASN A 1 193 ? 161.97600 323.31100 -6.12500  1.000 41.30089  ? 228 ASN F ND2 1 
ATOM   1258 N N   . ARG A 1 194 ? 164.77600 320.40500 -6.04900  1.000 33.46398  ? 229 ARG F N   1 
ATOM   1259 C CA  . ARG A 1 194 ? 165.56200 320.44600 -4.82100  1.000 37.89497  ? 229 ARG F CA  1 
ATOM   1260 C C   . ARG A 1 194 ? 167.04400 320.36500 -5.12200  1.000 43.07579  ? 229 ARG F C   1 
ATOM   1261 O O   . ARG A 1 194 ? 167.84400 321.06000 -4.48400  1.000 42.90129  ? 229 ARG F O   1 
ATOM   1262 C CB  . ARG A 1 194 ? 165.17500 319.30400 -3.88300  1.000 34.13984  ? 229 ARG F CB  1 
ATOM   1263 C CG  . ARG A 1 194 ? 165.82400 319.37400 -2.48400  1.000 41.40586  ? 229 ARG F CG  1 
ATOM   1264 C CD  . ARG A 1 194 ? 165.34000 318.25500 -1.53800  1.000 42.32127  ? 229 ARG F CD  1 
ATOM   1265 N NE  . ARG A 1 194 ? 165.89600 318.40100 -0.19300  1.000 35.99468  ? 229 ARG F NE  1 
ATOM   1266 C CZ  . ARG A 1 194 ? 165.65600 317.60000 0.83800   1.000 41.83490  ? 229 ARG F CZ  1 
ATOM   1267 N NH1 . ARG A 1 194 ? 164.85500 316.55300 0.73300   1.000 44.05285  ? 229 ARG F NH1 1 
ATOM   1268 N NH2 . ARG A 1 194 ? 166.24200 317.85100 2.01100   1.000 39.94117  ? 229 ARG F NH2 1 
ATOM   1269 N N   . LEU A 1 195 ? 167.42100 319.61600 -6.15400  1.000 38.82871  ? 230 LEU F N   1 
ATOM   1270 C CA  . LEU A 1 195 ? 168.82500 319.58900 -6.52500  1.000 32.66365  ? 230 LEU F CA  1 
ATOM   1271 C C   . LEU A 1 195 ? 169.26300 320.96400 -6.99600  1.000 38.83740  ? 230 LEU F C   1 
ATOM   1272 O O   . LEU A 1 195 ? 170.35100 321.43100 -6.64000  1.000 39.55455  ? 230 LEU F O   1 
ATOM   1273 C CB  . LEU A 1 195 ? 169.08000 318.52700 -7.59100  1.000 32.04264  ? 230 LEU F CB  1 
ATOM   1274 C CG  . LEU A 1 195 ? 170.50400 318.48400 -8.13900  1.000 36.79613  ? 230 LEU F CG  1 
ATOM   1275 C CD1 . LEU A 1 195 ? 171.45900 318.16800 -6.99500  1.000 35.58888  ? 230 LEU F CD1 1 
ATOM   1276 C CD2 . LEU A 1 195 ? 170.61500 317.42900 -9.23200  1.000 32.05071  ? 230 LEU F CD2 1 
ATOM   1277 N N   . LEU A 1 196 ? 168.44000 321.62600 -7.81100  1.000 39.10766  ? 231 LEU F N   1 
ATOM   1278 C CA  . LEU A 1 196 ? 168.85600 322.94000 -8.30400  1.000 39.31903  ? 231 LEU F CA  1 
ATOM   1279 C C   . LEU A 1 196 ? 168.95100 323.97200 -7.16600  1.000 41.76639  ? 231 LEU F C   1 
ATOM   1280 O O   . LEU A 1 196 ? 169.88300 324.78300 -7.13800  1.000 44.21477  ? 231 LEU F O   1 
ATOM   1281 C CB  . LEU A 1 196 ? 167.90200 323.40700 -9.39900  1.000 35.76033  ? 231 LEU F CB  1 
ATOM   1282 C CG  . LEU A 1 196 ? 167.70100 322.44900 -10.57200 1.000 38.40585  ? 231 LEU F CG  1 
ATOM   1283 C CD1 . LEU A 1 196 ? 166.82400 323.05200 -11.65100 1.000 36.53945  ? 231 LEU F CD1 1 
ATOM   1284 C CD2 . LEU A 1 196 ? 169.05400 322.13700 -11.16400 1.000 37.23605  ? 231 LEU F CD2 1 
ATOM   1285 N N   . GLU A 1 197 ? 168.03000 323.94700 -6.19600  1.000 36.94051  ? 232 GLU F N   1 
ATOM   1286 C CA  . GLU A 1 197 ? 168.13600 324.93300 -5.11500  1.000 42.20337  ? 232 GLU F CA  1 
ATOM   1287 C C   . GLU A 1 197 ? 169.29400 324.63300 -4.16600  1.000 43.79149  ? 232 GLU F C   1 
ATOM   1288 O O   . GLU A 1 197 ? 169.98000 325.56500 -3.70700  1.000 40.77486  ? 232 GLU F O   1 
ATOM   1289 C CB  . GLU A 1 197 ? 166.83200 325.07100 -4.33900  1.000 39.83134  ? 232 GLU F CB  1 
ATOM   1290 C CG  . GLU A 1 197 ? 165.73500 325.58700 -5.19400  1.000 51.59349  ? 232 GLU F CG  1 
ATOM   1291 C CD  . GLU A 1 197 ? 165.94700 327.08000 -5.44700  1.000 60.11682  ? 232 GLU F CD  1 
ATOM   1292 O OE1 . GLU A 1 197 ? 166.86400 327.66800 -4.80600  1.000 55.05325  ? 232 GLU F OE1 1 
ATOM   1293 O OE2 . GLU A 1 197 ? 165.23300 327.64700 -6.30400  1.000 50.66699  ? 232 GLU F OE2 1 
ATOM   1294 N N   . ILE A 1 198 ? 169.59800 323.35300 -3.95000  1.000 40.32815  ? 233 ILE F N   1 
ATOM   1295 C CA  . ILE A 1 198 ? 170.72100 323.01800 -3.08900  1.000 34.04647  ? 233 ILE F CA  1 
ATOM   1296 C C   . ILE A 1 198 ? 171.99800 323.41800 -3.77500  1.000 34.46329  ? 233 ILE F C   1 
ATOM   1297 O O   . ILE A 1 198 ? 172.92200 323.95100 -3.14100  1.000 39.20754  ? 233 ILE F O   1 
ATOM   1298 C CB  . ILE A 1 198 ? 170.71900 321.52300 -2.72600  1.000 32.31167  ? 233 ILE F CB  1 
ATOM   1299 C CG1 . ILE A 1 198 ? 169.56700 321.20400 -1.76900  1.000 39.20542  ? 233 ILE F CG1 1 
ATOM   1300 C CG2 . ILE A 1 198 ? 172.06600 321.07900 -2.19400  1.000 35.08210  ? 233 ILE F CG2 1 
ATOM   1301 C CD1 . ILE A 1 198 ? 169.43500 319.73900 -1.42100  1.000 30.60094  ? 233 ILE F CD1 1 
ATOM   1302 N N   . THR A 1 199 ? 172.07100 323.18300 -5.08300  1.000 39.69201  ? 234 THR F N   1 
ATOM   1303 C CA  . THR A 1 199 ? 173.23600 323.61800 -5.82600  1.000 42.64753  ? 234 THR F CA  1 
ATOM   1304 C C   . THR A 1 199 ? 173.38700 325.13000 -5.82900  1.000 35.48679  ? 234 THR F C   1 
ATOM   1305 O O   . THR A 1 199 ? 174.50100 325.62100 -5.71000  1.000 44.76705  ? 234 THR F O   1 
ATOM   1306 C CB  . THR A 1 199 ? 173.12000 323.10000 -7.27000  1.000 42.94116  ? 234 THR F CB  1 
ATOM   1307 O OG1 . THR A 1 199 ? 173.18500 321.66400 -7.27300  1.000 37.35974  ? 234 THR F OG1 1 
ATOM   1308 C CG2 . THR A 1 199 ? 174.21900 323.66600 -8.16200  1.000 38.37004  ? 234 THR F CG2 1 
ATOM   1309 N N   . ARG A 1 200 ? 172.29400 325.87600 -5.84400  1.000 38.28197  ? 235 ARG F N   1 
ATOM   1310 C CA  . ARG A 1 200 ? 172.37000 327.33600 -5.81600  1.000 41.53833  ? 235 ARG F CA  1 
ATOM   1311 C C   . ARG A 1 200 ? 172.91900 327.85400 -4.47800  1.000 45.12039  ? 235 ARG F C   1 
ATOM   1312 O O   . ARG A 1 200 ? 173.87800 328.65000 -4.43700  1.000 37.19505  ? 235 ARG F O   1 
ATOM   1313 C CB  . ARG A 1 200 ? 170.98700 327.83100 -6.17200  1.000 41.65893  ? 235 ARG F CB  1 
ATOM   1314 C CG  . ARG A 1 200 ? 170.87900 329.21300 -6.67400  1.000 48.54030  ? 235 ARG F CG  1 
ATOM   1315 C CD  . ARG A 1 200 ? 169.39600 329.31400 -7.05200  1.000 55.44783  ? 235 ARG F CD  1 
ATOM   1316 N NE  . ARG A 1 200 ? 169.34800 328.99800 -8.48400  1.000 67.08941  ? 235 ARG F NE  1 
ATOM   1317 C CZ  . ARG A 1 200 ? 168.27600 328.68300 -9.21000  1.000 69.08916  ? 235 ARG F CZ  1 
ATOM   1318 N NH1 . ARG A 1 200 ? 167.06100 328.61600 -8.67800  1.000 64.10127  ? 235 ARG F NH1 1 
ATOM   1319 N NH2 . ARG A 1 200 ? 168.41300 328.51200 -10.52700 1.000 64.76181  ? 235 ARG F NH2 1 
ATOM   1320 N N   . GLU A 1 201 ? 172.41800 327.29300 -3.36700  1.000 36.44901  ? 236 GLU F N   1 
ATOM   1321 C CA  . GLU A 1 201 ? 172.89200 327.74800 -2.06400  1.000 35.02788  ? 236 GLU F CA  1 
ATOM   1322 C C   . GLU A 1 201 ? 174.35900 327.35500 -1.89100  1.000 37.71874  ? 236 GLU F C   1 
ATOM   1323 O O   . GLU A 1 201 ? 175.14800 328.13300 -1.34800  1.000 37.72688  ? 236 GLU F O   1 
ATOM   1324 C CB  . GLU A 1 201 ? 172.02200 327.16400 -0.93000  1.000 30.09361  ? 236 GLU F CB  1 
ATOM   1325 C CG  . GLU A 1 201 ? 170.52300 327.49200 -1.04700  1.000 28.91524  ? 236 GLU F CG  1 
ATOM   1326 C CD  . GLU A 1 201 ? 169.64200 326.96300 0.12300   1.000 44.40884  ? 236 GLU F CD  1 
ATOM   1327 O OE1 . GLU A 1 201 ? 170.15200 326.58800 1.20800   1.000 33.15246  ? 236 GLU F OE1 1 
ATOM   1328 O OE2 . GLU A 1 201 ? 168.40100 326.94600 -0.04900  1.000 51.26900  ? 236 GLU F OE2 1 
ATOM   1329 N N   . PHE A 1 202 ? 174.74000 326.13800 -2.30000  1.000 34.45007  ? 237 PHE F N   1 
ATOM   1330 C CA  . PHE A 1 202 ? 176.13400 325.71700 -2.16300  1.000 34.58606  ? 237 PHE F CA  1 
ATOM   1331 C C   . PHE A 1 202 ? 177.05500 326.48300 -3.12300  1.000 44.97514  ? 237 PHE F C   1 
ATOM   1332 O O   . PHE A 1 202 ? 178.23900 326.68300 -2.82200  1.000 42.54432  ? 237 PHE F O   1 
ATOM   1333 C CB  . PHE A 1 202 ? 176.26100 324.21100 -2.38700  1.000 37.82881  ? 237 PHE F CB  1 
ATOM   1334 C CG  . PHE A 1 202 ? 176.02300 323.38500 -1.14400  1.000 36.62144  ? 237 PHE F CG  1 
ATOM   1335 C CD1 . PHE A 1 202 ? 176.32200 323.89400 0.10900   1.000 35.93314  ? 237 PHE F CD1 1 
ATOM   1336 C CD2 . PHE A 1 202 ? 175.45800 322.11200 -1.23000  1.000 35.51354  ? 237 PHE F CD2 1 
ATOM   1337 C CE1 . PHE A 1 202 ? 176.09300 323.13400 1.27400   1.000 38.13774  ? 237 PHE F CE1 1 
ATOM   1338 C CE2 . PHE A 1 202 ? 175.22000 321.34500 -0.07400  1.000 37.62551  ? 237 PHE F CE2 1 
ATOM   1339 C CZ  . PHE A 1 202 ? 175.53600 321.86200 1.18000   1.000 34.23909  ? 237 PHE F CZ  1 
ATOM   1340 N N   . SER A 1 203 ? 176.53000 326.93500 -4.27100  1.000 37.47856  ? 238 SER F N   1 
ATOM   1341 C CA  . SER A 1 203 ? 177.35000 327.64900 -5.24100  1.000 41.83690  ? 238 SER F CA  1 
ATOM   1342 C C   . SER A 1 203 ? 177.63800 329.06800 -4.80500  1.000 41.84744  ? 238 SER F C   1 
ATOM   1343 O O   . SER A 1 203 ? 178.76400 329.54100 -4.96400  1.000 43.44577  ? 238 SER F O   1 
ATOM   1344 C CB  . SER A 1 203 ? 176.65000 327.70200 -6.59600  1.000 36.19728  ? 238 SER F CB  1 
ATOM   1345 O OG  . SER A 1 203 ? 176.44700 326.39800 -7.11400  1.000 53.73405  ? 238 SER F OG  1 
ATOM   1346 N N   . VAL A 1 204 ? 176.62800 329.78300 -4.31000  1.000 45.01113  ? 239 VAL F N   1 
ATOM   1347 C CA  . VAL A 1 204 ? 176.85800 331.17900 -3.94200  1.000 50.56629  ? 239 VAL F CA  1 
ATOM   1348 C C   . VAL A 1 204 ? 177.64000 331.33200 -2.64300  1.000 47.74046  ? 239 VAL F C   1 
ATOM   1349 O O   . VAL A 1 204 ? 178.19600 332.40400 -2.39500  1.000 50.57302  ? 239 VAL F O   1 
ATOM   1350 C CB  . VAL A 1 204 ? 175.55600 331.99700 -3.84900  1.000 56.05596  ? 239 VAL F CB  1 
ATOM   1351 C CG1 . VAL A 1 204 ? 174.80000 331.96100 -5.18700  1.000 48.40296  ? 239 VAL F CG1 1 
ATOM   1352 C CG2 . VAL A 1 204 ? 174.69500 331.50200 -2.69200  1.000 53.91354  ? 239 VAL F CG2 1 
ATOM   1353 N N   . ASN A 1 205 ? 177.71300 330.29000 -1.81600  1.000 45.85125  ? 240 ASN F N   1 
ATOM   1354 C CA  . ASN A 1 205 ? 178.34400 330.35900 -0.50700  1.000 43.87021  ? 240 ASN F CA  1 
ATOM   1355 C C   . ASN A 1 205 ? 179.60400 329.51400 -0.40000  1.000 45.74476  ? 240 ASN F C   1 
ATOM   1356 O O   . ASN A 1 205 ? 180.00100 329.13600 0.70500   1.000 40.59434  ? 240 ASN F O   1 
ATOM   1357 C CB  . ASN A 1 205 ? 177.32700 329.95500 0.55700   1.000 46.09295  ? 240 ASN F CB  1 
ATOM   1358 C CG  . ASN A 1 205 ? 176.15300 330.92100 0.62600   1.000 48.51406  ? 240 ASN F CG  1 
ATOM   1359 O OD1 . ASN A 1 205 ? 174.99400 330.50800 0.66100   1.000 52.85754  ? 240 ASN F OD1 1 
ATOM   1360 N ND2 . ASN A 1 205 ? 176.45200 332.21100 0.69600   1.000 48.37011  ? 240 ASN F ND2 1 
ATOM   1361 N N   . ALA A 1 206 ? 180.19300 329.13200 -1.51900  1.000 40.56189  ? 241 ALA F N   1 
ATOM   1362 C CA  . ALA A 1 206 ? 181.46900 328.43200 -1.46400  1.000 43.26493  ? 241 ALA F CA  1 
ATOM   1363 C C   . ALA A 1 206 ? 181.38600 327.16800 -0.61100  1.000 35.21285  ? 241 ALA F C   1 
ATOM   1364 O O   . ALA A 1 206 ? 182.30400 326.84000 0.14400   1.000 36.71706  ? 241 ALA F O   1 
ATOM   1365 C CB  . ALA A 1 206 ? 182.55900 329.36700 -0.93900  1.000 40.93737  ? 241 ALA F CB  1 
ATOM   1366 N N   . GLY A 1 207 ? 180.29000 326.42900 -0.74900  1.000 37.70376  ? 242 GLY F N   1 
ATOM   1367 C CA  . GLY A 1 207 ? 180.15400 325.15400 -0.08100  1.000 33.26556  ? 242 GLY F CA  1 
ATOM   1368 C C   . GLY A 1 207 ? 179.76200 325.14300 1.38300   1.000 28.23098  ? 242 GLY F C   1 
ATOM   1369 O O   . GLY A 1 207 ? 179.64000 324.04500 1.93500   1.000 30.11058  ? 242 GLY F O   1 
ATOM   1370 N N   . VAL A 1 208 ? 179.68500 326.29700 2.05400   1.000 33.62705  ? 243 VAL F N   1 
ATOM   1371 C CA  . VAL A 1 208 ? 179.31400 326.41700 3.47700   1.000 35.46877  ? 243 VAL F CA  1 
ATOM   1372 C C   . VAL A 1 208 ? 178.15000 327.39100 3.66900   1.000 34.18929  ? 243 VAL F C   1 
ATOM   1373 O O   . VAL A 1 208 ? 178.32100 328.59900 3.48300   1.000 42.22735  ? 243 VAL F O   1 
ATOM   1374 C CB  . VAL A 1 208 ? 180.50700 326.84700 4.34200   1.000 39.16860  ? 243 VAL F CB  1 
ATOM   1375 C CG1 . VAL A 1 208 ? 180.11200 326.84100 5.83600   1.000 34.84871  ? 243 VAL F CG1 1 
ATOM   1376 C CG2 . VAL A 1 208 ? 181.67500 325.90600 4.10500   1.000 22.19825  ? 243 VAL F CG2 1 
ATOM   1377 N N   . THR A 1 209 ? 176.96700 326.88200 4.01500   1.000 29.12489  ? 244 THR F N   1 
ATOM   1378 C CA  . THR A 1 209 ? 175.78700 327.72900 4.16600   1.000 32.49112  ? 244 THR F CA  1 
ATOM   1379 C C   . THR A 1 209 ? 175.31900 327.74500 5.61800   1.000 35.14047  ? 244 THR F C   1 
ATOM   1380 O O   . THR A 1 209 ? 175.54200 326.78400 6.36300   1.000 29.41329  ? 244 THR F O   1 
ATOM   1381 C CB  . THR A 1 209 ? 174.59700 327.28400 3.28700   1.000 36.68050  ? 244 THR F CB  1 
ATOM   1382 O OG1 . THR A 1 209 ? 174.07200 326.03700 3.75500   1.000 35.42631  ? 244 THR F OG1 1 
ATOM   1383 C CG2 . THR A 1 209 ? 174.99900 327.14300 1.81700   1.000 37.99487  ? 244 THR F CG2 1 
ATOM   1384 N N   . THR A 1 210 ? 174.84100 328.89600 6.06800   1.000 36.46726  ? 245 THR F N   1 
ATOM   1385 C CA  . THR A 1 210 ? 174.22800 328.96300 7.39000   1.000 33.31916  ? 245 THR F CA  1 
ATOM   1386 C C   . THR A 1 210 ? 173.36900 330.21100 7.29100   1.000 31.75237  ? 245 THR F C   1 
ATOM   1387 O O   . THR A 1 210 ? 173.88700 331.25700 6.88400   1.000 34.80989  ? 245 THR F O   1 
ATOM   1388 C CB  . THR A 1 210 ? 175.23700 329.07600 8.53200   1.000 33.21173  ? 245 THR F CB  1 
ATOM   1389 O OG1 . THR A 1 210 ? 174.53300 329.27700 9.75600   1.000 29.77102  ? 245 THR F OG1 1 
ATOM   1390 C CG2 . THR A 1 210 ? 176.13000 330.29500 8.31700   1.000 30.94022  ? 245 THR F CG2 1 
ATOM   1391 N N   . PRO A 1 211 ? 172.10000 330.18300 7.70600   1.000 29.81450  ? 246 PRO F N   1 
ATOM   1392 C CA  . PRO A 1 211 ? 171.44800 329.01600 8.29900   1.000 28.27700  ? 246 PRO F CA  1 
ATOM   1393 C C   . PRO A 1 211 ? 171.20300 327.88300 7.31200   1.000 31.68438  ? 246 PRO F C   1 
ATOM   1394 O O   . PRO A 1 211 ? 171.45100 328.01300 6.11900   1.000 34.49754  ? 246 PRO F O   1 
ATOM   1395 C CB  . PRO A 1 211 ? 170.08500 329.57200 8.75400   1.000 30.28193  ? 246 PRO F CB  1 
ATOM   1396 C CG  . PRO A 1 211 ? 170.24200 331.09500 8.73400   1.000 37.41443  ? 246 PRO F CG  1 
ATOM   1397 C CD  . PRO A 1 211 ? 171.19800 331.34700 7.62400   1.000 27.86293  ? 246 PRO F CD  1 
ATOM   1398 N N   . VAL A 1 212 ? 170.80500 326.73700 7.84800   1.000 31.84339  ? 247 VAL F N   1 
ATOM   1399 C CA  . VAL A 1 212 ? 170.48900 325.55100 7.05600   1.000 36.35320  ? 247 VAL F CA  1 
ATOM   1400 C C   . VAL A 1 212 ? 169.02200 325.63400 6.60100   1.000 29.91234  ? 247 VAL F C   1 
ATOM   1401 O O   . VAL A 1 212 ? 168.09900 325.57400 7.42200   1.000 35.73053  ? 247 VAL F O   1 
ATOM   1402 C CB  . VAL A 1 212 ? 170.79400 324.28100 7.85100   1.000 31.84031  ? 247 VAL F CB  1 
ATOM   1403 C CG1 . VAL A 1 212 ? 170.40300 323.01900 7.05000   1.000 29.52651  ? 247 VAL F CG1 1 
ATOM   1404 C CG2 . VAL A 1 212 ? 172.28700 324.31000 8.27300   1.000 27.93877  ? 247 VAL F CG2 1 
ATOM   1405 N N   . SER A 1 213 ? 168.79700 325.75800 5.29800   1.000 34.96867  ? 248 SER F N   1 
ATOM   1406 C CA  . SER A 1 213 ? 167.46000 325.92200 4.73500   1.000 34.20470  ? 248 SER F CA  1 
ATOM   1407 C C   . SER A 1 213 ? 166.65900 324.61200 4.71200   1.000 33.54835  ? 248 SER F C   1 
ATOM   1408 O O   . SER A 1 213 ? 167.17200 323.51300 4.96100   1.000 30.44809  ? 248 SER F O   1 
ATOM   1409 C CB  . SER A 1 213 ? 167.55600 326.43800 3.31200   1.000 25.32448  ? 248 SER F CB  1 
ATOM   1410 O OG  . SER A 1 213 ? 168.23200 325.46500 2.54700   1.000 33.67138  ? 248 SER F OG  1 
ATOM   1411 N N   . THR A 1 214 ? 165.35700 324.75000 4.42700   1.000 30.80546  ? 249 THR F N   1 
ATOM   1412 C CA  . THR A 1 214 ? 164.50100 323.57100 4.26400   1.000 39.27424  ? 249 THR F CA  1 
ATOM   1413 C C   . THR A 1 214 ? 164.87600 322.76400 3.01600   1.000 36.22989  ? 249 THR F C   1 
ATOM   1414 O O   . THR A 1 214 ? 164.49400 321.59500 2.92300   1.000 36.67579  ? 249 THR F O   1 
ATOM   1415 C CB  . THR A 1 214 ? 163.00600 323.94900 4.25400   1.000 33.84247  ? 249 THR F CB  1 
ATOM   1416 O OG1 . THR A 1 214 ? 162.73400 324.87400 3.19900   1.000 38.32040  ? 249 THR F OG1 1 
ATOM   1417 C CG2 . THR A 1 214 ? 162.59400 324.57500 5.58300   1.000 37.21930  ? 249 THR F CG2 1 
ATOM   1418 N N   . TYR A 1 215 ? 165.57600 323.37400 2.04600   1.000 31.36656  ? 250 TYR F N   1 
ATOM   1419 C CA  . TYR A 1 215 ? 166.10300 322.63000 0.90400   1.000 37.22602  ? 250 TYR F CA  1 
ATOM   1420 C C   . TYR A 1 215 ? 167.23500 321.71800 1.33000   1.000 39.03296  ? 250 TYR F C   1 
ATOM   1421 O O   . TYR A 1 215 ? 167.28700 320.55000 0.92200   1.000 33.99122  ? 250 TYR F O   1 
ATOM   1422 C CB  . TYR A 1 215 ? 166.60000 323.59500 -0.17800  1.000 36.89545  ? 250 TYR F CB  1 
ATOM   1423 C CG  . TYR A 1 215 ? 165.50500 324.35100 -0.88000  1.000 46.06142  ? 250 TYR F CG  1 
ATOM   1424 C CD1 . TYR A 1 215 ? 164.27100 323.75300 -1.13200  1.000 45.60793  ? 250 TYR F CD1 1 
ATOM   1425 C CD2 . TYR A 1 215 ? 165.66400 325.69100 -1.20700  1.000 48.93383  ? 250 TYR F CD2 1 
ATOM   1426 C CE1 . TYR A 1 215 ? 163.25300 324.45200 -1.75700  1.000 49.05506  ? 250 TYR F CE1 1 
ATOM   1427 C CE2 . TYR A 1 215 ? 164.64900 326.39900 -1.82200  1.000 50.52259  ? 250 TYR F CE2 1 
ATOM   1428 C CZ  . TYR A 1 215 ? 163.44700 325.77600 -2.08800  1.000 47.46873  ? 250 TYR F CZ  1 
ATOM   1429 O OH  . TYR A 1 215 ? 162.45300 326.49300 -2.70300  1.000 53.83462  ? 250 TYR F OH  1 
ATOM   1430 N N   . MET A 1 216 ? 168.13000 322.21800 2.19500   1.000 33.68026  ? 251 MET F N   1 
ATOM   1431 C CA  . MET A 1 216 ? 169.18600 321.35800 2.71100   1.000 25.22753  ? 251 MET F CA  1 
ATOM   1432 C C   . MET A 1 216 ? 168.60000 320.27900 3.59100   1.000 34.96660  ? 251 MET F C   1 
ATOM   1433 O O   . MET A 1 216 ? 169.02600 319.12300 3.53700   1.000 40.06795  ? 251 MET F O   1 
ATOM   1434 C CB  . MET A 1 216 ? 170.18500 322.17400 3.52200   1.000 36.16212  ? 251 MET F CB  1 
ATOM   1435 C CG  . MET A 1 216 ? 170.92900 323.19000 2.69200   1.000 36.49829  ? 251 MET F CG  1 
ATOM   1436 S SD  . MET A 1 216 ? 172.12000 322.33400 1.71900   1.000 36.77191  ? 251 MET F SD  1 
ATOM   1437 C CE  . MET A 1 216 ? 172.70200 323.68500 0.68700   1.000 26.79534  ? 251 MET F CE  1 
ATOM   1438 N N   . LEU A 1 217 ? 167.61000 320.63100 4.40400   1.000 34.20431  ? 252 LEU F N   1 
ATOM   1439 C CA  . LEU A 1 217 ? 167.06200 319.64200 5.31100   1.000 37.17705  ? 252 LEU F CA  1 
ATOM   1440 C C   . LEU A 1 217 ? 165.62700 320.06100 5.61900   1.000 38.87783  ? 252 LEU F C   1 
ATOM   1441 O O   . LEU A 1 217 ? 165.40900 321.10400 6.23700   1.000 38.24685  ? 252 LEU F O   1 
ATOM   1442 C CB  . LEU A 1 217 ? 167.95000 319.56400 6.54800   1.000 38.34485  ? 252 LEU F CB  1 
ATOM   1443 C CG  . LEU A 1 217 ? 167.86700 318.35000 7.45200   1.000 45.01597  ? 252 LEU F CG  1 
ATOM   1444 C CD1 . LEU A 1 217 ? 168.26900 317.15400 6.60600   1.000 39.01121  ? 252 LEU F CD1 1 
ATOM   1445 C CD2 . LEU A 1 217 ? 168.81300 318.48700 8.62100   1.000 40.15117  ? 252 LEU F CD2 1 
ATOM   1446 N N   . THR A 1 218 ? 164.64200 319.27000 5.18800   1.000 39.94321  ? 253 THR F N   1 
ATOM   1447 C CA  . THR A 1 218 ? 163.26400 319.65900 5.45400   1.000 36.85707  ? 253 THR F CA  1 
ATOM   1448 C C   . THR A 1 218 ? 162.99100 319.60300 6.95700   1.000 41.45639  ? 253 THR F C   1 
ATOM   1449 O O   . THR A 1 218 ? 163.62700 318.85600 7.70700   1.000 37.14928  ? 253 THR F O   1 
ATOM   1450 C CB  . THR A 1 218 ? 162.27100 318.75600 4.71600   1.000 42.04137  ? 253 THR F CB  1 
ATOM   1451 O OG1 . THR A 1 218 ? 162.11900 317.52100 5.43500   1.000 42.11099  ? 253 THR F OG1 1 
ATOM   1452 C CG2 . THR A 1 218 ? 162.71500 318.47000 3.27700   1.000 33.28592  ? 253 THR F CG2 1 
ATOM   1453 N N   . ASN A 1 219 ? 162.00200 320.38200 7.38900   1.000 38.76307  ? 254 ASN F N   1 
ATOM   1454 C CA  . ASN A 1 219 ? 161.61900 320.34900 8.79200   1.000 41.11222  ? 254 ASN F CA  1 
ATOM   1455 C C   . ASN A 1 219 ? 161.27700 318.93400 9.23300   1.000 48.16108  ? 254 ASN F C   1 
ATOM   1456 O O   . ASN A 1 219 ? 161.58500 318.53500 10.36900  1.000 41.56451  ? 254 ASN F O   1 
ATOM   1457 C CB  . ASN A 1 219 ? 160.45100 321.29800 9.05200   1.000 41.34408  ? 254 ASN F CB  1 
ATOM   1458 C CG  . ASN A 1 219 ? 160.84800 322.75500 8.93400   1.000 49.15738  ? 254 ASN F CG  1 
ATOM   1459 O OD1 . ASN A 1 219 ? 161.77500 323.21900 9.61300   1.000 43.92113  ? 254 ASN F OD1 1 
ATOM   1460 N ND2 . ASN A 1 219 ? 160.13800 323.49200 8.10300   1.000 48.90798  ? 254 ASN F ND2 1 
ATOM   1461 N N   . SER A 1 220 ? 160.65500 318.15100 8.35300   1.000 42.30723  ? 255 SER F N   1 
ATOM   1462 C CA  . SER A 1 220 ? 160.40100 316.76200 8.71000   1.000 44.33648  ? 255 SER F CA  1 
ATOM   1463 C C   . SER A 1 220 ? 161.70400 315.99400 8.90600   1.000 45.02060  ? 255 SER F C   1 
ATOM   1464 O O   . SER A 1 220 ? 161.85400 315.25000 9.89000   1.000 41.17801  ? 255 SER F O   1 
ATOM   1465 C CB  . SER A 1 220 ? 159.55300 316.09600 7.62800   1.000 47.21843  ? 255 SER F CB  1 
ATOM   1466 O OG  . SER A 1 220 ? 159.42900 314.71000 7.89000   1.000 55.41181  ? 255 SER F OG  1 
ATOM   1467 N N   . GLU A 1 221 ? 162.68500 316.22100 8.02200   1.000 38.66983  ? 256 GLU F N   1 
ATOM   1468 C CA  . GLU A 1 221 ? 163.96700 315.53900 8.14000   1.000 41.07229  ? 256 GLU F CA  1 
ATOM   1469 C C   . GLU A 1 221 ? 164.77700 316.04500 9.32600   1.000 45.83728  ? 256 GLU F C   1 
ATOM   1470 O O   . GLU A 1 221 ? 165.44400 315.24900 9.99400   1.000 41.68513  ? 256 GLU F O   1 
ATOM   1471 C CB  . GLU A 1 221 ? 164.74800 315.71100 6.83200   1.000 43.85326  ? 256 GLU F CB  1 
ATOM   1472 C CG  . GLU A 1 221 ? 163.97600 315.27800 5.57100   1.000 48.64956  ? 256 GLU F CG  1 
ATOM   1473 C CD  . GLU A 1 221 ? 164.63700 315.72300 4.25900   1.000 47.97254  ? 256 GLU F CD  1 
ATOM   1474 O OE1 . GLU A 1 221 ? 165.56900 316.55800 4.30900   1.000 44.53968  ? 256 GLU F OE1 1 
ATOM   1475 O OE2 . GLU A 1 221 ? 164.28200 315.16500 3.18600   1.000 45.60829  ? 256 GLU F OE2 1 
ATOM   1476 N N   . LEU A 1 222 ? 164.66500 317.33200 9.66100   1.000 44.06293  ? 257 LEU F N   1 
ATOM   1477 C CA  . LEU A 1 222 ? 165.42200 317.85600 10.78900  1.000 33.03191  ? 257 LEU F CA  1 
ATOM   1478 C C   . LEU A 1 222 ? 164.87600 317.28800 12.08400  1.000 37.94160  ? 257 LEU F C   1 
ATOM   1479 O O   . LEU A 1 222 ? 165.64200 316.86100 12.95200  1.000 33.64602  ? 257 LEU F O   1 
ATOM   1480 C CB  . LEU A 1 222 ? 165.39300 319.37600 10.79700  1.000 38.28291  ? 257 LEU F CB  1 
ATOM   1481 C CG  . LEU A 1 222 ? 166.10300 320.08500 11.95700  1.000 39.95189  ? 257 LEU F CG  1 
ATOM   1482 C CD1 . LEU A 1 222 ? 167.58300 319.73300 12.03800  1.000 30.08075  ? 257 LEU F CD1 1 
ATOM   1483 C CD2 . LEU A 1 222 ? 165.92400 321.60100 11.77200  1.000 33.25721  ? 257 LEU F CD2 1 
ATOM   1484 N N   . LEU A 1 223 ? 163.54900 317.27200 12.22500  1.000 32.10122  ? 258 LEU F N   1 
ATOM   1485 C CA  . LEU A 1 223 ? 162.94000 316.72100 13.42600  1.000 38.96487  ? 258 LEU F CA  1 
ATOM   1486 C C   . LEU A 1 223 ? 163.23700 315.23500 13.55200  1.000 41.40403  ? 258 LEU F C   1 
ATOM   1487 O O   . LEU A 1 223 ? 163.49700 314.73300 14.65900  1.000 39.59361  ? 258 LEU F O   1 
ATOM   1488 C CB  . LEU A 1 223 ? 161.43400 316.97600 13.41200  1.000 37.19789  ? 258 LEU F CB  1 
ATOM   1489 C CG  . LEU A 1 223 ? 161.06000 318.44300 13.58200  1.000 47.17476  ? 258 LEU F CG  1 
ATOM   1490 C CD1 . LEU A 1 223 ? 159.55900 318.63900 13.43300  1.000 41.82585  ? 258 LEU F CD1 1 
ATOM   1491 C CD2 . LEU A 1 223 ? 161.50600 318.90600 14.97300  1.000 38.73820  ? 258 LEU F CD2 1 
ATOM   1492 N N   . SER A 1 224 ? 163.21200 314.51200 12.42600  1.000 40.82475  ? 259 SER F N   1 
ATOM   1493 C CA  . SER A 1 224 ? 163.58500 313.10200 12.45900  1.000 47.93494  ? 259 SER F CA  1 
ATOM   1494 C C   . SER A 1 224 ? 165.05700 312.91700 12.82000  1.000 44.04274  ? 259 SER F C   1 
ATOM   1495 O O   . SER A 1 224 ? 165.41300 311.95600 13.51100  1.000 43.70452  ? 259 SER F O   1 
ATOM   1496 C CB  . SER A 1 224 ? 163.27500 312.45800 11.10700  1.000 42.82621  ? 259 SER F CB  1 
ATOM   1497 O OG  . SER A 1 224 ? 163.54700 311.07500 11.14900  1.000 54.47741  ? 259 SER F OG  1 
ATOM   1498 N N   . LEU A 1 225 ? 165.91300 313.84700 12.41200  1.000 37.58538  ? 260 LEU F N   1 
ATOM   1499 C CA  . LEU A 1 225 ? 167.31600 313.74800 12.77700  1.000 38.19549  ? 260 LEU F CA  1 
ATOM   1500 C C   . LEU A 1 225 ? 167.52300 314.05800 14.24800  1.000 45.05304  ? 260 LEU F C   1 
ATOM   1501 O O   . LEU A 1 225 ? 168.25100 313.34100 14.94300  1.000 39.75838  ? 260 LEU F O   1 
ATOM   1502 C CB  . LEU A 1 225 ? 168.11300 314.74700 11.94800  1.000 34.78259  ? 260 LEU F CB  1 
ATOM   1503 C CG  . LEU A 1 225 ? 169.62100 314.69000 12.13400  1.000 39.97579  ? 260 LEU F CG  1 
ATOM   1504 C CD1 . LEU A 1 225 ? 170.11700 313.26300 12.02300  1.000 41.29618  ? 260 LEU F CD1 1 
ATOM   1505 C CD2 . LEU A 1 225 ? 170.30200 315.61800 11.12500  1.000 34.03360  ? 260 LEU F CD2 1 
ATOM   1506 N N   . ILE A 1 226 ? 166.75300 315.00200 14.77400  1.000 37.21864  ? 261 ILE F N   1 
ATOM   1507 C CA  . ILE A 1 226 ? 166.87300 315.31900 16.18000  1.000 36.66412  ? 261 ILE F CA  1 
ATOM   1508 C C   . ILE A 1 226 ? 166.43500 314.12000 16.99900  1.000 42.80552  ? 261 ILE F C   1 
ATOM   1509 O O   . ILE A 1 226 ? 167.05700 313.78800 18.01500  1.000 41.35059  ? 261 ILE F O   1 
ATOM   1510 C CB  . ILE A 1 226 ? 166.06800 316.58900 16.49400  1.000 36.96017  ? 261 ILE F CB  1 
ATOM   1511 C CG1 . ILE A 1 226 ? 166.72300 317.79600 15.79000  1.000 28.61132  ? 261 ILE F CG1 1 
ATOM   1512 C CG2 . ILE A 1 226 ? 166.01400 316.81700 17.98600  1.000 27.98310  ? 261 ILE F CG2 1 
ATOM   1513 C CD1 . ILE A 1 226 ? 166.20300 319.11200 16.27000  1.000 29.40643  ? 261 ILE F CD1 1 
ATOM   1514 N N   . ASN A 1 227 ? 165.35500 313.44900 16.58600  1.000 41.90471  ? 262 ASN F N   1 
ATOM   1515 C CA  . ASN A 1 227 ? 164.89700 312.34000 17.41600  1.000 49.12030  ? 262 ASN F CA  1 
ATOM   1516 C C   . ASN A 1 227 ? 165.91800 311.21700 17.45100  1.000 42.65436  ? 262 ASN F C   1 
ATOM   1517 O O   . ASN A 1 227 ? 165.92900 310.42400 18.39600  1.000 44.62386  ? 262 ASN F O   1 
ATOM   1518 C CB  . ASN A 1 227 ? 163.56300 311.76700 16.94900  1.000 43.99428  ? 262 ASN F CB  1 
ATOM   1519 C CG  . ASN A 1 227 ? 162.52500 311.79700 18.03700  1.000 55.16124  ? 262 ASN F CG  1 
ATOM   1520 O OD1 . ASN A 1 227 ? 162.41300 312.78000 18.77800  1.000 64.87595  ? 262 ASN F OD1 1 
ATOM   1521 N ND2 . ASN A 1 227 ? 161.81400 310.67900 18.20800  1.000 60.82384  ? 262 ASN F ND2 1 
ATOM   1522 N N   . ASP A 1 228 ? 166.73000 311.08600 16.40900  1.000 42.03192  ? 263 ASP F N   1 
ATOM   1523 C CA  . ASP A 1 228 ? 167.65500 309.97200 16.34700  1.000 45.36063  ? 263 ASP F CA  1 
ATOM   1524 C C   . ASP A 1 228 ? 169.04900 310.31700 16.86900  1.000 49.49348  ? 263 ASP F C   1 
ATOM   1525 O O   . ASP A 1 228 ? 169.95900 309.49700 16.74800  1.000 53.27714  ? 263 ASP F O   1 
ATOM   1526 C CB  . ASP A 1 228 ? 167.71100 309.50000 14.89800  1.000 45.89004  ? 263 ASP F CB  1 
ATOM   1527 C CG  . ASP A 1 228 ? 166.63600 308.48000 14.60300  1.000 56.94208  ? 263 ASP F CG  1 
ATOM   1528 O OD1 . ASP A 1 228 ? 166.23100 307.75700 15.54900  1.000 63.37343  ? 263 ASP F OD1 1 
ATOM   1529 O OD2 . ASP A 1 228 ? 166.13200 308.46200 13.46200  1.000 58.16362  ? 263 ASP F OD2 1 
ATOM   1530 N N   . MET A 1 229 ? 169.23100 311.52600 17.51900  1.000 47.90065  ? 264 MET F N   1 
ATOM   1531 C CA  . MET A 1 229 ? 170.56100 311.92300 17.95300  1.000 43.42370  ? 264 MET F CA  1 
ATOM   1532 C C   . MET A 1 229 ? 170.88100 311.33000 19.31900  1.000 40.88809  ? 264 MET F C   1 
ATOM   1533 O O   . MET A 1 229 ? 169.99000 311.13900 20.15100  1.000 40.89513  ? 264 MET F O   1 
ATOM   1534 C CB  . MET A 1 229 ? 170.76600 313.44600 17.99500  1.000 40.01274  ? 264 MET F CB  1 
ATOM   1535 C CG  . MET A 1 229 ? 171.08300 314.11600 16.64500  1.000 41.34547  ? 264 MET F CG  1 
ATOM   1536 S SD  . MET A 1 229 ? 170.51200 315.82900 16.48400  1.000 47.99449  ? 264 MET F SD  1 
ATOM   1537 C CE  . MET A 1 229 ? 171.60100 316.72200 17.58300  1.000 40.14076  ? 264 MET F CE  1 
ATOM   1538 N N   . PRO A 1 230 ? 172.14900 311.08700 19.56700  1.000 47.72433  ? 265 PRO F N   1 
ATOM   1539 C CA  . PRO A 1 230 ? 172.61400 310.59300 20.87800  1.000 43.70611  ? 265 PRO F CA  1 
ATOM   1540 C C   . PRO A 1 230 ? 172.63600 311.71200 21.91300  1.000 38.97973  ? 265 PRO F C   1 
ATOM   1541 O O   . PRO A 1 230 ? 173.68700 312.14000 22.39000  1.000 41.26974  ? 265 PRO F O   1 
ATOM   1542 C CB  . PRO A 1 230 ? 174.02200 310.07800 20.54800  1.000 50.18512  ? 265 PRO F CB  1 
ATOM   1543 C CG  . PRO A 1 230 ? 174.48000 310.98800 19.42500  1.000 47.35052  ? 265 PRO F CG  1 
ATOM   1544 C CD  . PRO A 1 230 ? 173.24400 311.26400 18.60000  1.000 44.05971  ? 265 PRO F CD  1 
ATOM   1545 N N   . ILE A 1 231 ? 171.45900 312.29000 22.15700  1.000 32.50263  ? 266 ILE F N   1 
ATOM   1546 C CA  . ILE A 1 231 ? 171.27400 313.35300 23.13000  1.000 34.89373  ? 266 ILE F CA  1 
ATOM   1547 C C   . ILE A 1 231 ? 170.10500 312.96200 24.02700  1.000 36.12663  ? 266 ILE F C   1 
ATOM   1548 O O   . ILE A 1 231 ? 169.32100 312.07100 23.70500  1.000 38.80791  ? 266 ILE F O   1 
ATOM   1549 C CB  . ILE A 1 231 ? 170.99500 314.71600 22.45600  1.000 34.10889  ? 266 ILE F CB  1 
ATOM   1550 C CG1 . ILE A 1 231 ? 169.77600 314.62000 21.52900  1.000 40.06119  ? 266 ILE F CG1 1 
ATOM   1551 C CG2 . ILE A 1 231 ? 172.17200 315.09500 21.56600  1.000 27.80175  ? 266 ILE F CG2 1 
ATOM   1552 C CD1 . ILE A 1 231 ? 169.41000 315.92500 20.83900  1.000 34.70073  ? 266 ILE F CD1 1 
ATOM   1553 N N   . THR A 1 232 ? 169.98000 313.66600 25.14900  1.000 35.53891  ? 267 THR F N   1 
ATOM   1554 C CA  . THR A 1 232 ? 168.94700 313.39300 26.14000  1.000 39.00621  ? 267 THR F CA  1 
ATOM   1555 C C   . THR A 1 232 ? 167.56300 313.75800 25.60400  1.000 40.44806  ? 267 THR F C   1 
ATOM   1556 O O   . THR A 1 232 ? 167.42100 314.48800 24.62400  1.000 43.37245  ? 267 THR F O   1 
ATOM   1557 C CB  . THR A 1 232 ? 169.22600 314.13100 27.44600  1.000 47.19370  ? 267 THR F CB  1 
ATOM   1558 O OG1 . THR A 1 232 ? 168.97200 315.53100 27.26300  1.000 46.52768  ? 267 THR F OG1 1 
ATOM   1559 C CG2 . THR A 1 232 ? 170.67600 313.89400 27.90600  1.000 48.01001  ? 267 THR F CG2 1 
ATOM   1560 N N   . ASN A 1 233 ? 166.52500 313.23600 26.26300  1.000 40.69676  ? 268 ASN F N   1 
ATOM   1561 C CA  . ASN A 1 233 ? 165.17000 313.57700 25.84000  1.000 41.96976  ? 268 ASN F CA  1 
ATOM   1562 C C   . ASN A 1 233 ? 164.81500 315.04500 26.06500  1.000 40.94646  ? 268 ASN F C   1 
ATOM   1563 O O   . ASN A 1 233 ? 164.10400 315.63100 25.23600  1.000 43.47889  ? 268 ASN F O   1 
ATOM   1564 C CB  . ASN A 1 233 ? 164.17800 312.68300 26.58100  1.000 50.12249  ? 268 ASN F CB  1 
ATOM   1565 C CG  . ASN A 1 233 ? 163.96000 311.34700 25.88100  1.000 53.05420  ? 268 ASN F CG  1 
ATOM   1566 O OD1 . ASN A 1 233 ? 163.82200 311.27900 24.65900  1.000 55.39537  ? 268 ASN F OD1 1 
ATOM   1567 N ND2 . ASN A 1 233 ? 163.97000 310.26900 26.66200  1.000 52.84997  ? 268 ASN F ND2 1 
ATOM   1568 N N   . ASP A 1 234 ? 165.33400 315.68900 27.11300  1.000 40.42642  ? 269 ASP F N   1 
ATOM   1569 C CA  . ASP A 1 234 ? 165.08100 317.13000 27.20400  1.000 48.23628  ? 269 ASP F CA  1 
ATOM   1570 C C   . ASP A 1 234 ? 165.82000 317.91000 26.12500  1.000 35.56914  ? 269 ASP F C   1 
ATOM   1571 O O   . ASP A 1 234 ? 165.31800 318.94200 25.68400  1.000 33.67456  ? 269 ASP F O   1 
ATOM   1572 C CB  . ASP A 1 234 ? 165.37000 317.73000 28.58700  1.000 48.42352  ? 269 ASP F CB  1 
ATOM   1573 C CG  . ASP A 1 234 ? 164.53500 317.10800 29.70200  1.000 65.42862  ? 269 ASP F CG  1 
ATOM   1574 O OD1 . ASP A 1 234 ? 163.43700 316.55600 29.42300  1.000 65.39099  ? 269 ASP F OD1 1 
ATOM   1575 O OD2 . ASP A 1 234 ? 164.94300 317.26300 30.87800  1.000 70.18089  ? 269 ASP F OD2 1 
ATOM   1576 N N   . GLN A 1 235 ? 166.91000 317.37600 25.58100  1.000 35.48628  ? 270 GLN F N   1 
ATOM   1577 C CA  . GLN A 1 235 ? 167.59000 318.15000 24.56200  1.000 34.82213  ? 270 GLN F CA  1 
ATOM   1578 C C   . GLN A 1 235 ? 166.89100 317.97000 23.23500  1.000 38.28068  ? 270 GLN F C   1 
ATOM   1579 O O   . GLN A 1 235 ? 166.82000 318.92000 22.44200  1.000 35.32399  ? 270 GLN F O   1 
ATOM   1580 C CB  . GLN A 1 235 ? 169.05000 317.70800 24.43300  1.000 32.04673  ? 270 GLN F CB  1 
ATOM   1581 C CG  . GLN A 1 235 ? 169.95900 318.04100 25.60900  1.000 39.26894  ? 270 GLN F CG  1 
ATOM   1582 C CD  . GLN A 1 235 ? 170.55300 319.44600 25.51600  1.000 47.47988  ? 270 GLN F CD  1 
ATOM   1583 O OE1 . GLN A 1 235 ? 170.34200 320.17800 24.53000  1.000 43.16283  ? 270 GLN F OE1 1 
ATOM   1584 N NE2 . GLN A 1 235 ? 171.31700 319.82200 26.52900  1.000 49.10192  ? 270 GLN F NE2 1 
ATOM   1585 N N   . LYS A 1 236 ? 166.29000 316.80200 23.01900  1.000 35.61862  ? 271 LYS F N   1 
ATOM   1586 C CA  . LYS A 1 236 ? 165.52100 316.63400 21.80300  1.000 33.59127  ? 271 LYS F CA  1 
ATOM   1587 C C   . LYS A 1 236 ? 164.27500 317.50000 21.86700  1.000 28.90507  ? 271 LYS F C   1 
ATOM   1588 O O   . LYS A 1 236 ? 163.89600 318.12700 20.87300  1.000 31.15596  ? 271 LYS F O   1 
ATOM   1589 C CB  . LYS A 1 236 ? 165.12600 315.16500 21.62900  1.000 33.31068  ? 271 LYS F CB  1 
ATOM   1590 C CG  . LYS A 1 236 ? 166.28700 314.20700 21.42900  1.000 37.06452  ? 271 LYS F CG  1 
ATOM   1591 C CD  . LYS A 1 236 ? 165.80300 312.76200 21.29500  1.000 39.49524  ? 271 LYS F CD  1 
ATOM   1592 C CE  . LYS A 1 236 ? 166.97600 311.80600 21.12700  1.000 38.80279  ? 271 LYS F CE  1 
ATOM   1593 N NZ  . LYS A 1 236 ? 166.57100 310.38300 21.01100  1.000 45.52708  ? 271 LYS F NZ  1 
ATOM   1594 N N   . LYS A 1 237 ? 163.65000 317.59300 23.04200  1.000 30.42100  ? 272 LYS F N   1 
ATOM   1595 C CA  . LYS A 1 237 ? 162.50300 318.48500 23.15800  1.000 34.68513  ? 272 LYS F CA  1 
ATOM   1596 C C   . LYS A 1 237 ? 162.89300 319.95300 22.99300  1.000 37.68810  ? 272 LYS F C   1 
ATOM   1597 O O   . LYS A 1 237 ? 162.18600 320.70500 22.30200  1.000 32.93289  ? 272 LYS F O   1 
ATOM   1598 C CB  . LYS A 1 237 ? 161.83400 318.24400 24.51100  1.000 37.86229  ? 272 LYS F CB  1 
ATOM   1599 C CG  . LYS A 1 237 ? 160.65300 319.13100 24.82200  1.000 46.80163  ? 272 LYS F CG  1 
ATOM   1600 C CD  . LYS A 1 237 ? 160.14200 318.84700 26.24800  1.000 56.55774  ? 272 LYS F CD  1 
ATOM   1601 C CE  . LYS A 1 237 ? 158.97200 319.75800 26.61500  1.000 54.78382  ? 272 LYS F CE  1 
ATOM   1602 N NZ  . LYS A 1 237 ? 158.29500 319.33200 27.87000  1.000 63.17726  ? 272 LYS F NZ  1 
ATOM   1603 N N   . LEU A 1 238 ? 164.10800 320.31800 23.42600  1.000 31.19834  ? 273 LEU F N   1 
ATOM   1604 C CA  . LEU A 1 238 ? 164.53900 321.70800 23.32100  1.000 30.05597  ? 273 LEU F CA  1 
ATOM   1605 C C   . LEU A 1 238 ? 164.80600 322.06900 21.87600  1.000 28.30120  ? 273 LEU F C   1 
ATOM   1606 O O   . LEU A 1 238 ? 164.31200 323.08300 21.37500  1.000 26.29718  ? 273 LEU F O   1 
ATOM   1607 C CB  . LEU A 1 238 ? 165.82100 321.93100 24.12400  1.000 29.34953  ? 273 LEU F CB  1 
ATOM   1608 C CG  . LEU A 1 238 ? 166.31300 323.37600 24.19600  1.000 25.95308  ? 273 LEU F CG  1 
ATOM   1609 C CD1 . LEU A 1 238 ? 165.32000 324.27600 24.90000  1.000 27.82580  ? 273 LEU F CD1 1 
ATOM   1610 C CD2 . LEU A 1 238 ? 167.72300 323.50100 24.78200  1.000 27.10577  ? 273 LEU F CD2 1 
ATOM   1611 N N   . MET A 1 239 ? 165.56500 321.22700 21.18300  1.000 25.27968  ? 274 MET F N   1 
ATOM   1612 C CA  . MET A 1 239 ? 165.88000 321.52500 19.79700  1.000 25.38550  ? 274 MET F CA  1 
ATOM   1613 C C   . MET A 1 239 ? 164.65000 321.40700 18.90100  1.000 25.44914  ? 274 MET F C   1 
ATOM   1614 O O   . MET A 1 239 ? 164.53400 322.15800 17.92800  1.000 27.45501  ? 274 MET F O   1 
ATOM   1615 C CB  . MET A 1 239 ? 166.97300 320.57500 19.32200  1.000 24.01339  ? 274 MET F CB  1 
ATOM   1616 C CG  . MET A 1 239 ? 168.26500 320.67400 20.15000  1.000 23.52047  ? 274 MET F CG  1 
ATOM   1617 S SD  . MET A 1 239 ? 169.53500 319.51800 19.61000  1.000 35.01194  ? 274 MET F SD  1 
ATOM   1618 C CE  . MET A 1 239 ? 169.96800 320.06100 17.95100  1.000 27.28550  ? 274 MET F CE  1 
ATOM   1619 N N   . SER A 1 240 ? 163.69900 320.52900 19.23600  1.000 24.22390  ? 275 SER F N   1 
ATOM   1620 C CA  . SER A 1 240 ? 162.50900 320.36200 18.40200  1.000 28.59358  ? 275 SER F CA  1 
ATOM   1621 C C   . SER A 1 240 ? 161.52500 321.50400 18.56600  1.000 29.06137  ? 275 SER F C   1 
ATOM   1622 O O   . SER A 1 240 ? 160.84800 321.86300 17.60200  1.000 33.68683  ? 275 SER F O   1 
ATOM   1623 C CB  . SER A 1 240 ? 161.80500 319.04400 18.73400  1.000 25.70788  ? 275 SER F CB  1 
ATOM   1624 O OG  . SER A 1 240 ? 162.67100 317.94800 18.50300  1.000 30.02483  ? 275 SER F OG  1 
ATOM   1625 N N   . ASN A 1 241 ? 161.50800 322.14900 19.73500  1.000 28.20818  ? 276 ASN F N   1 
ATOM   1626 C CA  . ASN A 1 241 ? 160.63500 323.29700 19.94600  1.000 24.05572  ? 276 ASN F CA  1 
ATOM   1627 C C   . ASN A 1 241 ? 161.25100 324.60400 19.47300  1.000 28.15839  ? 276 ASN F C   1 
ATOM   1628 O O   . ASN A 1 241 ? 160.58200 325.63300 19.54000  1.000 32.74691  ? 276 ASN F O   1 
ATOM   1629 C CB  . ASN A 1 241 ? 160.24000 323.42700 21.42000  1.000 30.13517  ? 276 ASN F CB  1 
ATOM   1630 C CG  . ASN A 1 241 ? 159.36000 322.27100 21.89900  1.000 37.35977  ? 276 ASN F CG  1 
ATOM   1631 O OD1 . ASN A 1 241 ? 158.62200 321.67000 21.12300  1.000 35.84982  ? 276 ASN F OD1 1 
ATOM   1632 N ND2 . ASN A 1 241 ? 159.43100 321.96900 23.18500  1.000 46.40586  ? 276 ASN F ND2 1 
ATOM   1633 N N   . ASN A 1 242 ? 162.53300 324.61300 19.10400  1.000 25.50428  ? 277 ASN F N   1 
ATOM   1634 C CA  . ASN A 1 242 ? 163.21500 325.80600 18.59500  1.000 24.22865  ? 277 ASN F CA  1 
ATOM   1635 C C   . ASN A 1 242 ? 163.98000 325.47500 17.32700  1.000 23.36058  ? 277 ASN F C   1 
ATOM   1636 O O   . ASN A 1 242 ? 165.14200 325.85100 17.17400  1.000 20.76537  ? 277 ASN F O   1 
ATOM   1637 C CB  . ASN A 1 242 ? 164.17000 326.35900 19.64700  1.000 22.97203  ? 277 ASN F CB  1 
ATOM   1638 C CG  . ASN A 1 242 ? 163.47800 326.67100 20.94000  1.000 23.79182  ? 277 ASN F CG  1 
ATOM   1639 O OD1 . ASN A 1 242 ? 162.94600 327.76200 21.10200  1.000 26.12966  ? 277 ASN F OD1 1 
ATOM   1640 N ND2 . ASN A 1 242 ? 163.42600 325.70500 21.84700  1.000 20.75930  ? 277 ASN F ND2 1 
ATOM   1641 N N   . VAL A 1 243 ? 163.29300 324.88600 16.33800  1.000 23.56996  ? 278 VAL F N   1 
ATOM   1642 C CA  . VAL A 1 243 ? 163.99200 324.45500 15.12900  1.000 23.81409  ? 278 VAL F CA  1 
ATOM   1643 C C   . VAL A 1 243 ? 164.52200 325.62200 14.32500  1.000 23.92055  ? 278 VAL F C   1 
ATOM   1644 O O   . VAL A 1 243 ? 165.54800 325.49200 13.65400  1.000 26.07367  ? 278 VAL F O   1 
ATOM   1645 C CB  . VAL A 1 243 ? 163.09200 323.57200 14.23000  1.000 32.40078  ? 278 VAL F CB  1 
ATOM   1646 C CG1 . VAL A 1 243 ? 162.76400 322.27800 14.89400  1.000 34.13560  ? 278 VAL F CG1 1 
ATOM   1647 C CG2 . VAL A 1 243 ? 161.81100 324.28900 13.89100  1.000 28.28378  ? 278 VAL F CG2 1 
ATOM   1648 N N   . GLN A 1 244 ? 163.84700 326.76100 14.32600  1.000 26.90046  ? 279 GLN F N   1 
ATOM   1649 C CA  . GLN A 1 244 ? 164.39200 327.85400 13.53000  1.000 27.44947  ? 279 GLN F CA  1 
ATOM   1650 C C   . GLN A 1 244 ? 165.68100 328.39700 14.14600  1.000 28.57520  ? 279 GLN F C   1 
ATOM   1651 O O   . GLN A 1 244 ? 166.61800 328.77500 13.42600  1.000 25.41312  ? 279 GLN F O   1 
ATOM   1652 C CB  . GLN A 1 244 ? 163.32500 328.91100 13.29900  1.000 31.74405  ? 279 GLN F CB  1 
ATOM   1653 C CG  . GLN A 1 244 ? 162.20100 328.30600 12.40900  1.000 42.23069  ? 279 GLN F CG  1 
ATOM   1654 C CD  . GLN A 1 244 ? 162.66200 327.77600 11.01400  1.000 43.60258  ? 279 GLN F CD  1 
ATOM   1655 O OE1 . GLN A 1 244 ? 163.55300 328.32900 10.35900  1.000 40.51163  ? 279 GLN F OE1 1 
ATOM   1656 N NE2 . GLN A 1 244 ? 162.05300 326.67600 10.58800  1.000 46.87523  ? 279 GLN F NE2 1 
ATOM   1657 N N   . ILE A 1 245 ? 165.74800 328.45400 15.47500  1.000 20.03927  ? 280 ILE F N   1 
ATOM   1658 C CA  . ILE A 1 245 ? 166.99500 328.86100 16.09900  1.000 18.69249  ? 280 ILE F CA  1 
ATOM   1659 C C   . ILE A 1 245 ? 168.06900 327.80400 15.85900  1.000 20.25343  ? 280 ILE F C   1 
ATOM   1660 O O   . ILE A 1 245 ? 169.20900 328.13300 15.52100  1.000 17.98659  ? 280 ILE F O   1 
ATOM   1661 C CB  . ILE A 1 245 ? 166.76200 329.10800 17.59800  1.000 22.83392  ? 280 ILE F CB  1 
ATOM   1662 C CG1 . ILE A 1 245 ? 165.83500 330.30400 17.80000  1.000 20.13267  ? 280 ILE F CG1 1 
ATOM   1663 C CG2 . ILE A 1 245 ? 168.07300 329.44100 18.27200  1.000 19.19192  ? 280 ILE F CG2 1 
ATOM   1664 C CD1 . ILE A 1 245 ? 165.59600 330.66100 19.29400  1.000 24.06088  ? 280 ILE F CD1 1 
ATOM   1665 N N   . VAL A 1 246 ? 167.69000 326.51900 15.87600  1.000 19.64810  ? 281 VAL F N   1 
ATOM   1666 C CA  . VAL A 1 246 ? 168.66600 325.47400 15.60000  1.000 16.77272  ? 281 VAL F CA  1 
ATOM   1667 C C   . VAL A 1 246 ? 169.21200 325.62500 14.19200  1.000 20.49140  ? 281 VAL F C   1 
ATOM   1668 O O   . VAL A 1 246 ? 170.42500 325.51300 13.96300  1.000 22.59012  ? 281 VAL F O   1 
ATOM   1669 C CB  . VAL A 1 246 ? 168.03900 324.08200 15.80400  1.000 19.82374  ? 281 VAL F CB  1 
ATOM   1670 C CG1 . VAL A 1 246 ? 169.00300 323.01400 15.28500  1.000 17.43668  ? 281 VAL F CG1 1 
ATOM   1671 C CG2 . VAL A 1 246 ? 167.65000 323.85700 17.26400  1.000 18.58539  ? 281 VAL F CG2 1 
ATOM   1672 N N   . ARG A 1 247 ? 168.33800 325.91800 13.22800  1.000 18.40037  ? 282 ARG F N   1 
ATOM   1673 C CA  . ARG A 1 247 ? 168.79900 326.13300 11.85600  1.000 21.80059  ? 282 ARG F CA  1 
ATOM   1674 C C   . ARG A 1 247 ? 169.73600 327.31700 11.77100  1.000 20.57828  ? 282 ARG F C   1 
ATOM   1675 O O   . ARG A 1 247 ? 170.71100 327.28900 11.01800  1.000 23.19353  ? 282 ARG F O   1 
ATOM   1676 C CB  . ARG A 1 247 ? 167.61400 326.36700 10.90900  1.000 26.38232  ? 282 ARG F CB  1 
ATOM   1677 C CG  . ARG A 1 247 ? 166.70900 325.15400 10.69500  1.000 32.78603  ? 282 ARG F CG  1 
ATOM   1678 C CD  . ARG A 1 247 ? 165.57000 325.45800 9.70000   1.000 35.87707  ? 282 ARG F CD  1 
ATOM   1679 N NE  . ARG A 1 247 ? 164.77400 324.26300 9.44900   1.000 32.93916  ? 282 ARG F NE  1 
ATOM   1680 C CZ  . ARG A 1 247 ? 165.07600 323.35900 8.52600   1.000 35.16372  ? 282 ARG F CZ  1 
ATOM   1681 N NH1 . ARG A 1 247 ? 166.14200 323.49300 7.74400   1.000 25.80207  ? 282 ARG F NH1 1 
ATOM   1682 N NH2 . ARG A 1 247 ? 164.32400 322.26800 8.42000   1.000 35.07803  ? 282 ARG F NH2 1 
ATOM   1683 N N   . GLN A 1 248 ? 169.40800 328.40400 12.46500  1.000 23.36312  ? 283 GLN F N   1 
ATOM   1684 C CA  . GLN A 1 248 ? 170.26600 329.58100 12.40600  1.000 26.04281  ? 283 GLN F CA  1 
ATOM   1685 C C   . GLN A 1 248 ? 171.60100 329.35500 13.08100  1.000 21.02663  ? 283 GLN F C   1 
ATOM   1686 O O   . GLN A 1 248 ? 172.54100 330.10200 12.82400  1.000 25.29882  ? 283 GLN F O   1 
ATOM   1687 C CB  . GLN A 1 248 ? 169.55900 330.79700 12.99300  1.000 26.95916  ? 283 GLN F CB  1 
ATOM   1688 C CG  . GLN A 1 248 ? 168.37800 331.16700 12.14100  1.000 29.77543  ? 283 GLN F CG  1 
ATOM   1689 C CD  . GLN A 1 248 ? 167.51600 332.25100 12.72700  1.000 38.92306  ? 283 GLN F CD  1 
ATOM   1690 O OE1 . GLN A 1 248 ? 167.68900 332.66300 13.86800  1.000 36.04398  ? 283 GLN F OE1 1 
ATOM   1691 N NE2 . GLN A 1 248 ? 166.55600 332.71300 11.93900  1.000 56.31719  ? 283 GLN F NE2 1 
ATOM   1692 N N   . GLN A 1 249 ? 171.71900 328.34200 13.93000  1.000 22.11149  ? 284 GLN F N   1 
ATOM   1693 C CA  . GLN A 1 249 ? 172.99400 328.06500 14.57100  1.000 21.05799  ? 284 GLN F CA  1 
ATOM   1694 C C   . GLN A 1 249 ? 173.62400 326.77900 14.04800  1.000 25.79730  ? 284 GLN F C   1 
ATOM   1695 O O   . GLN A 1 249 ? 174.45200 326.17800 14.72400  1.000 25.83481  ? 284 GLN F O   1 
ATOM   1696 C CB  . GLN A 1 249 ? 172.74000 328.02400 16.07900  1.000 17.37398  ? 284 GLN F CB  1 
ATOM   1697 C CG  . GLN A 1 249 ? 172.33500 329.44200 16.56100  1.000 22.56278  ? 284 GLN F CG  1 
ATOM   1698 C CD  . GLN A 1 249 ? 172.14900 329.60100 18.06400  1.000 24.34712  ? 284 GLN F CD  1 
ATOM   1699 O OE1 . GLN A 1 249 ? 172.03800 328.61700 18.80900  1.000 22.43669  ? 284 GLN F OE1 1 
ATOM   1700 N NE2 . GLN A 1 249 ? 172.11400 330.86900 18.52400  1.000 24.61468  ? 284 GLN F NE2 1 
ATOM   1701 N N   . SER A 1 250 ? 173.33000 326.41500 12.79200  1.000 24.73854  ? 285 SER F N   1 
ATOM   1702 C CA  . SER A 1 250 ? 173.85600 325.21900 12.14000  1.000 17.76464  ? 285 SER F CA  1 
ATOM   1703 C C   . SER A 1 250 ? 174.59100 325.58600 10.86800  1.000 24.73607  ? 285 SER F C   1 
ATOM   1704 O O   . SER A 1 250 ? 174.46300 326.69400 10.33300  1.000 25.36606  ? 285 SER F O   1 
ATOM   1705 C CB  . SER A 1 250 ? 172.75900 324.22700 11.76000  1.000 17.90328  ? 285 SER F CB  1 
ATOM   1706 O OG  . SER A 1 250 ? 172.05100 323.74300 12.87700  1.000 23.24316  ? 285 SER F OG  1 
ATOM   1707 N N   . TYR A 1 251 ? 175.34200 324.61400 10.37100  1.000 21.27583  ? 286 TYR F N   1 
ATOM   1708 C CA  . TYR A 1 251 ? 176.08100 324.75700 9.13100   1.000 20.98623  ? 286 TYR F CA  1 
ATOM   1709 C C   . TYR A 1 251 ? 175.78400 323.57400 8.22200   1.000 24.22154  ? 286 TYR F C   1 
ATOM   1710 O O   . TYR A 1 251 ? 175.54900 322.45600 8.68400   1.000 24.65289  ? 286 TYR F O   1 
ATOM   1711 C CB  . TYR A 1 251 ? 177.58800 324.80000 9.38400   1.000 20.74269  ? 286 TYR F CB  1 
ATOM   1712 C CG  . TYR A 1 251 ? 178.11100 326.08400 9.96300   1.000 26.80408  ? 286 TYR F CG  1 
ATOM   1713 C CD1 . TYR A 1 251 ? 178.43400 327.14600 9.14300   1.000 28.18343  ? 286 TYR F CD1 1 
ATOM   1714 C CD2 . TYR A 1 251 ? 178.30500 326.22800 11.33800  1.000 25.91670  ? 286 TYR F CD2 1 
ATOM   1715 C CE1 . TYR A 1 251 ? 178.93300 328.31600 9.65100   1.000 34.54733  ? 286 TYR F CE1 1 
ATOM   1716 C CE2 . TYR A 1 251 ? 178.80300 327.41800 11.86200  1.000 24.05507  ? 286 TYR F CE2 1 
ATOM   1717 C CZ  . TYR A 1 251 ? 179.10800 328.45400 11.01300  1.000 29.20676  ? 286 TYR F CZ  1 
ATOM   1718 O OH  . TYR A 1 251 ? 179.61200 329.64300 11.49100  1.000 36.26962  ? 286 TYR F OH  1 
ATOM   1719 N N   . SER A 1 252 ? 175.75600 323.84000 6.92300   1.000 30.64909  ? 287 SER F N   1 
ATOM   1720 C CA  . SER A 1 252 ? 175.65000 322.80500 5.90100   1.000 28.92767  ? 287 SER F CA  1 
ATOM   1721 C C   . SER A 1 252 ? 176.90800 322.92400 5.04900   1.000 28.05731  ? 287 SER F C   1 
ATOM   1722 O O   . SER A 1 252 ? 177.18900 324.00300 4.51900   1.000 31.60750  ? 287 SER F O   1 
ATOM   1723 C CB  . SER A 1 252 ? 174.37100 322.94900 5.06900   1.000 36.02126  ? 287 SER F CB  1 
ATOM   1724 O OG  . SER A 1 252 ? 174.25100 321.87100 4.14200   1.000 35.82096  ? 287 SER F OG  1 
ATOM   1725 N N   . ILE A 1 253 ? 177.72500 321.87300 5.02500   1.000 25.67747  ? 288 ILE F N   1 
ATOM   1726 C CA  . ILE A 1 253 ? 179.02900 321.88500 4.35700   1.000 30.37651  ? 288 ILE F CA  1 
ATOM   1727 C C   . ILE A 1 253 ? 179.02900 320.88600 3.20300   1.000 32.89557  ? 288 ILE F C   1 
ATOM   1728 O O   . ILE A 1 253 ? 178.82100 319.68000 3.41900   1.000 25.90544  ? 288 ILE F O   1 
ATOM   1729 C CB  . ILE A 1 253 ? 180.18800 321.57000 5.32400   1.000 29.41309  ? 288 ILE F CB  1 
ATOM   1730 C CG1 . ILE A 1 253 ? 180.08400 322.40200 6.62000   1.000 29.31517  ? 288 ILE F CG1 1 
ATOM   1731 C CG2 . ILE A 1 253 ? 181.52000 321.69800 4.61000   1.000 31.51610  ? 288 ILE F CG2 1 
ATOM   1732 C CD1 . ILE A 1 253 ? 180.25000 321.60000 7.88200   1.000 31.94038  ? 288 ILE F CD1 1 
ATOM   1733 N N   . MET A 1 254 ? 179.44100 321.34900 2.02200   1.000 32.47163  ? 289 MET F N   1 
ATOM   1734 C CA  . MET A 1 254 ? 179.47600 320.45400 0.87300   1.000 38.40063  ? 289 MET F CA  1 
ATOM   1735 C C   . MET A 1 254 ? 180.74000 319.61100 0.93000   1.000 42.85901  ? 289 MET F C   1 
ATOM   1736 O O   . MET A 1 254 ? 181.85600 320.13600 0.94800   1.000 41.62394  ? 289 MET F O   1 
ATOM   1737 C CB  . MET A 1 254 ? 179.50800 321.26500 -0.42800  1.000 44.02836  ? 289 MET F CB  1 
ATOM   1738 C CG  . MET A 1 254 ? 178.28600 321.19600 -1.31000  1.000 45.89345  ? 289 MET F CG  1 
ATOM   1739 S SD  . MET A 1 254 ? 178.00500 319.55500 -2.01900  1.000 57.66773  ? 289 MET F SD  1 
ATOM   1740 C CE  . MET A 1 254 ? 179.66200 318.94900 -2.21100  1.000 57.48549  ? 289 MET F CE  1 
ATOM   1741 N N   . CYS A 1 255 ? 180.54000 318.30300 0.80700   1.000 38.28289  ? 290 CYS F N   1 
ATOM   1742 C CA  . CYS A 1 255 ? 181.53800 317.24100 0.84900   1.000 39.07337  ? 290 CYS F CA  1 
ATOM   1743 C C   . CYS A 1 255 ? 181.92800 316.93200 -0.59400  1.000 49.81370  ? 290 CYS F C   1 
ATOM   1744 O O   . CYS A 1 255 ? 182.79800 317.60700 -1.15900  1.000 48.86370  ? 290 CYS F O   1 
ATOM   1745 C CB  . CYS A 1 255 ? 181.01100 316.02400 1.59800   1.000 36.69086  ? 290 CYS F CB  1 
ATOM   1746 S SG  . CYS A 1 255 ? 180.93100 316.18100 3.43000   1.000 62.03978  ? 290 CYS F SG  1 
ATOM   1747 N N   . ILE A 1 256 ? 181.38300 315.85400 -1.17000  1.000 43.51307  ? 291 ILE F N   1 
ATOM   1748 C CA  . ILE A 1 256 ? 181.83900 315.40500 -2.48600  1.000 50.35739  ? 291 ILE F CA  1 
ATOM   1749 C C   . ILE A 1 256 ? 180.72200 314.92900 -3.40100  1.000 44.74926  ? 291 ILE F C   1 
ATOM   1750 O O   . ILE A 1 256 ? 179.60900 314.62200 -2.96700  1.000 40.95624  ? 291 ILE F O   1 
ATOM   1751 C CB  . ILE A 1 256 ? 182.84300 314.22500 -2.40700  1.000 47.71120  ? 291 ILE F CB  1 
ATOM   1752 C CG1 . ILE A 1 256 ? 182.45000 313.26400 -1.29100  1.000 41.03886  ? 291 ILE F CG1 1 
ATOM   1753 C CG2 . ILE A 1 256 ? 184.27300 314.68900 -2.35200  1.000 56.91189  ? 291 ILE F CG2 1 
ATOM   1754 C CD1 . ILE A 1 256 ? 181.13300 312.59900 -1.49200  1.000 50.62676  ? 291 ILE F CD1 1 
ATOM   1755 N N   . ILE A 1 257 ? 181.01000 315.01200 -4.70300  1.000 48.37347  ? 292 ILE F N   1 
ATOM   1756 C CA  . ILE A 1 257 ? 180.20400 314.37200 -5.73700  1.000 49.30968  ? 292 ILE F CA  1 
ATOM   1757 C C   . ILE A 1 257 ? 181.10000 313.26200 -6.26500  1.000 50.76389  ? 292 ILE F C   1 
ATOM   1758 O O   . ILE A 1 257 ? 182.09100 313.53100 -6.95300  1.000 46.31401  ? 292 ILE F O   1 
ATOM   1759 C CB  . ILE A 1 257 ? 179.84400 315.33300 -6.87900  1.000 55.85081  ? 292 ILE F CB  1 
ATOM   1760 C CG1 . ILE A 1 257 ? 178.90600 316.43900 -6.44000  1.000 53.84349  ? 292 ILE F CG1 1 
ATOM   1761 C CG2 . ILE A 1 257 ? 179.23300 314.57000 -8.04000  1.000 54.48064  ? 292 ILE F CG2 1 
ATOM   1762 C CD1 . ILE A 1 257 ? 177.47500 316.10400 -6.75900  1.000 55.43744  ? 292 ILE F CD1 1 
ATOM   1763 N N   . LYS A 1 258 ? 180.72900 312.01600 -6.02500  1.000 52.58614  ? 293 LYS F N   1 
ATOM   1764 C CA  . LYS A 1 258 ? 181.61500 310.93600 -6.42200  1.000 49.43357  ? 293 LYS F CA  1 
ATOM   1765 C C   . LYS A 1 258 ? 180.82500 309.65900 -6.56100  1.000 57.50677  ? 293 LYS F C   1 
ATOM   1766 O O   . LYS A 1 258 ? 180.11800 309.27700 -5.62100  1.000 54.01803  ? 293 LYS F O   1 
ATOM   1767 C CB  . LYS A 1 258 ? 182.73900 310.65600 -5.42800  1.000 57.88007  ? 293 LYS F CB  1 
ATOM   1768 C CG  . LYS A 1 258 ? 184.08000 310.47400 -6.10700  1.000 67.33299  ? 293 LYS F CG  1 
ATOM   1769 C CD  . LYS A 1 258 ? 185.19800 310.18100 -5.11300  1.000 68.76477  ? 293 LYS F CD  1 
ATOM   1770 C CE  . LYS A 1 258 ? 184.82800 308.91400 -4.29600  1.000 66.13752  ? 293 LYS F CE  1 
ATOM   1771 N NZ  . LYS A 1 258 ? 185.81500 308.51300 -3.22500  1.000 62.89395  ? 293 LYS F NZ  1 
ATOM   1772 N N   . GLU A 1 259 ? 180.97800 308.98000 -7.68800  1.000 62.39970  ? 294 GLU F N   1 
ATOM   1773 C CA  . GLU A 1 259 ? 180.36900 307.67200 -7.85300  1.000 60.13833  ? 294 GLU F CA  1 
ATOM   1774 C C   . GLU A 1 259 ? 178.86700 307.76100 -7.59900  1.000 53.54375  ? 294 GLU F C   1 
ATOM   1775 O O   . GLU A 1 259 ? 178.30400 307.03700 -6.76900  1.000 50.43841  ? 294 GLU F O   1 
ATOM   1776 C CB  . GLU A 1 259 ? 181.05100 306.73000 -6.86100  1.000 52.43616  ? 294 GLU F CB  1 
ATOM   1777 C CG  . GLU A 1 259 ? 182.53800 306.60000 -7.18400  1.000 65.50026  ? 294 GLU F CG  1 
ATOM   1778 C CD  . GLU A 1 259 ? 183.31900 305.74400 -6.20200  1.000 73.72996  ? 294 GLU F CD  1 
ATOM   1779 O OE1 . GLU A 1 259 ? 182.72200 305.24500 -5.22000  1.000 66.37760  ? 294 GLU F OE1 1 
ATOM   1780 O OE2 . GLU A 1 259 ? 184.55700 305.64000 -6.38200  1.000 75.72254  ? 294 GLU F OE2 1 
ATOM   1781 N N   . GLU A 1 260 ? 178.22000 308.66400 -8.33700  1.000 52.47987  ? 295 GLU F N   1 
ATOM   1782 C CA  . GLU A 1 260 ? 176.76800 308.80600 -8.33500  1.000 59.51053  ? 295 GLU F CA  1 
ATOM   1783 C C   . GLU A 1 260 ? 176.21900 309.14200 -6.94600  1.000 52.09379  ? 295 GLU F C   1 
ATOM   1784 O O   . GLU A 1 260 ? 175.12600 308.70100 -6.57400  1.000 51.25996  ? 295 GLU F O   1 
ATOM   1785 C CB  . GLU A 1 260 ? 176.10300 307.54400 -8.88300  1.000 58.26893  ? 295 GLU F CB  1 
ATOM   1786 C CG  . GLU A 1 260 ? 176.79400 306.98400 -10.09800 1.000 62.23086  ? 295 GLU F CG  1 
ATOM   1787 C CD  . GLU A 1 260 ? 176.07900 305.76400 -10.61600 1.000 72.48720  ? 295 GLU F CD  1 
ATOM   1788 O OE1 . GLU A 1 260 ? 176.15400 304.70800 -9.94000  1.000 68.16951  ? 295 GLU F OE1 1 
ATOM   1789 O OE2 . GLU A 1 260 ? 175.42700 305.87500 -11.68200 1.000 75.48045  ? 295 GLU F OE2 1 
ATOM   1790 N N   . VAL A 1 261 ? 176.98300 309.88700 -6.15200  1.000 52.81023  ? 296 VAL F N   1 
ATOM   1791 C CA  . VAL A 1 261 ? 176.57300 310.27100 -4.80400  1.000 50.80486  ? 296 VAL F CA  1 
ATOM   1792 C C   . VAL A 1 261 ? 176.96300 311.72100 -4.54800  1.000 47.08624  ? 296 VAL F C   1 
ATOM   1793 O O   . VAL A 1 261 ? 178.11800 312.11000 -4.75600  1.000 50.69252  ? 296 VAL F O   1 
ATOM   1794 C CB  . VAL A 1 261 ? 177.16100 309.35500 -3.72000  1.000 49.57116  ? 296 VAL F CB  1 
ATOM   1795 C CG1 . VAL A 1 261 ? 176.89300 309.95200 -2.35900  1.000 47.90504  ? 296 VAL F CG1 1 
ATOM   1796 C CG2 . VAL A 1 261 ? 176.53300 307.98000 -3.80500  1.000 54.42008  ? 296 VAL F CG2 1 
ATOM   1797 N N   . LEU A 1 262 ? 176.00600 312.51900 -4.09900  1.000 46.74462  ? 297 LEU F N   1 
ATOM   1798 C CA  . LEU A 1 262 ? 176.24900 313.88000 -3.64500  1.000 44.83390  ? 297 LEU F CA  1 
ATOM   1799 C C   . LEU A 1 262 ? 176.11800 313.87300 -2.13300  1.000 42.38412  ? 297 LEU F C   1 
ATOM   1800 O O   . LEU A 1 262 ? 175.07800 313.46900 -1.60600  1.000 40.14501  ? 297 LEU F O   1 
ATOM   1801 C CB  . LEU A 1 262 ? 175.26500 314.88000 -4.24500  1.000 43.99824  ? 297 LEU F CB  1 
ATOM   1802 C CG  . LEU A 1 262 ? 175.22200 316.18500 -3.43600  1.000 40.18292  ? 297 LEU F CG  1 
ATOM   1803 C CD1 . LEU A 1 262 ? 176.56700 316.89700 -3.45900  1.000 50.84683  ? 297 LEU F CD1 1 
ATOM   1804 C CD2 . LEU A 1 262 ? 174.13400 317.10700 -3.94800  1.000 43.23738  ? 297 LEU F CD2 1 
ATOM   1805 N N   . ALA A 1 263 ? 177.19900 314.19100 -1.43300  1.000 43.36560  ? 298 ALA F N   1 
ATOM   1806 C CA  . ALA A 1 263 ? 177.18600 314.13400 0.02000   1.000 40.15390  ? 298 ALA F CA  1 
ATOM   1807 C C   . ALA A 1 263 ? 177.57200 315.50600 0.55400   1.000 37.60644  ? 298 ALA F C   1 
ATOM   1808 O O   . ALA A 1 263 ? 178.51500 316.14900 0.05500   1.000 34.39222  ? 298 ALA F O   1 
ATOM   1809 C CB  . ALA A 1 263 ? 178.11800 313.05300 0.56900   1.000 37.31630  ? 298 ALA F CB  1 
ATOM   1810 N N   . TYR A 1 264 ? 176.89100 315.87900 1.63500   1.000 37.08828  ? 299 TYR F N   1 
ATOM   1811 C CA  . TYR A 1 264 ? 177.15000 317.10700 2.37700   1.000 32.86648  ? 299 TYR F CA  1 
ATOM   1812 C C   . TYR A 1 264 ? 176.81400 316.91700 3.84700   1.000 29.44458  ? 299 TYR F C   1 
ATOM   1813 O O   . TYR A 1 264 ? 176.03400 316.03700 4.21900   1.000 30.78776  ? 299 TYR F O   1 
ATOM   1814 C CB  . TYR A 1 264 ? 176.39400 318.32100 1.80700   1.000 30.39754  ? 299 TYR F CB  1 
ATOM   1815 C CG  . TYR A 1 264 ? 174.86800 318.23700 1.75500   1.000 30.24373  ? 299 TYR F CG  1 
ATOM   1816 C CD1 . TYR A 1 264 ? 174.22200 317.70300 0.63800   1.000 36.45679  ? 299 TYR F CD1 1 
ATOM   1817 C CD2 . TYR A 1 264 ? 174.08300 318.66900 2.80100   1.000 30.84631  ? 299 TYR F CD2 1 
ATOM   1818 C CE1 . TYR A 1 264 ? 172.84500 317.63000 0.56300   1.000 33.28395  ? 299 TYR F CE1 1 
ATOM   1819 C CE2 . TYR A 1 264 ? 172.69100 318.58800 2.74400   1.000 32.54890  ? 299 TYR F CE2 1 
ATOM   1820 C CZ  . TYR A 1 264 ? 172.08500 318.06300 1.61100   1.000 36.55660  ? 299 TYR F CZ  1 
ATOM   1821 O OH  . TYR A 1 264 ? 170.71600 317.98000 1.51900   1.000 34.34317  ? 299 TYR F OH  1 
ATOM   1822 N N   . VAL A 1 265 ? 177.53900 317.64900 4.69000   1.000 33.70316  ? 300 VAL F N   1 
ATOM   1823 C CA  . VAL A 1 265 ? 177.45500 317.50400 6.13800   1.000 34.14259  ? 300 VAL F CA  1 
ATOM   1824 C C   . VAL A 1 265 ? 176.57500 318.59800 6.73300   1.000 31.43655  ? 300 VAL F C   1 
ATOM   1825 O O   . VAL A 1 265 ? 176.73900 319.78700 6.42800   1.000 30.25167  ? 300 VAL F O   1 
ATOM   1826 C CB  . VAL A 1 265 ? 178.86400 317.55800 6.76100   1.000 39.86026  ? 300 VAL F CB  1 
ATOM   1827 C CG1 . VAL A 1 265 ? 178.77800 317.68600 8.26100   1.000 41.53116  ? 300 VAL F CG1 1 
ATOM   1828 C CG2 . VAL A 1 265 ? 179.64300 316.30700 6.40700   1.000 35.51837  ? 300 VAL F CG2 1 
ATOM   1829 N N   . VAL A 1 266 ? 175.64400 318.20700 7.58700   1.000 28.40029  ? 301 VAL F N   1 
ATOM   1830 C CA  . VAL A 1 266 ? 174.90300 319.16900 8.38000   1.000 26.30713  ? 301 VAL F CA  1 
ATOM   1831 C C   . VAL A 1 266 ? 175.48000 319.10400 9.78600   1.000 34.84530  ? 301 VAL F C   1 
ATOM   1832 O O   . VAL A 1 266 ? 175.53300 318.02600 10.39600  1.000 30.00582  ? 301 VAL F O   1 
ATOM   1833 C CB  . VAL A 1 266 ? 173.39600 318.89400 8.36800   1.000 29.85915  ? 301 VAL F CB  1 
ATOM   1834 C CG1 . VAL A 1 266 ? 172.71200 319.82100 9.32900   1.000 35.56135  ? 301 VAL F CG1 1 
ATOM   1835 C CG2 . VAL A 1 266 ? 172.82600 319.17900 6.96400   1.000 32.00165  ? 301 VAL F CG2 1 
ATOM   1836 N N   . GLN A 1 267 ? 175.96400 320.24800 10.26900  1.000 28.17396  ? 302 GLN F N   1 
ATOM   1837 C CA  . GLN A 1 267 ? 176.62300 320.36700 11.56400  1.000 25.54799  ? 302 GLN F CA  1 
ATOM   1838 C C   . GLN A 1 267 ? 175.64400 321.05600 12.51600  1.000 21.51302  ? 302 GLN F C   1 
ATOM   1839 O O   . GLN A 1 267 ? 175.38900 322.25000 12.36300  1.000 22.00613  ? 302 GLN F O   1 
ATOM   1840 C CB  . GLN A 1 267 ? 177.90300 321.17100 11.40100  1.000 26.56200  ? 302 GLN F CB  1 
ATOM   1841 C CG  . GLN A 1 267 ? 178.86300 321.11100 12.52000  1.000 25.97066  ? 302 GLN F CG  1 
ATOM   1842 C CD  . GLN A 1 267 ? 180.14200 321.84600 12.15900  1.000 31.29285  ? 302 GLN F CD  1 
ATOM   1843 O OE1 . GLN A 1 267 ? 181.01000 321.33200 11.45600  1.000 27.29542  ? 302 GLN F OE1 1 
ATOM   1844 N NE2 . GLN A 1 267 ? 180.26300 323.07300 12.67000  1.000 28.35710  ? 302 GLN F NE2 1 
ATOM   1845 N N   . LEU A 1 268 ? 175.04500 320.30200 13.47300  1.000 22.36213  ? 303 LEU F N   1 
ATOM   1846 C CA  . LEU A 1 268 ? 174.02000 320.85400 14.34800  1.000 20.71129  ? 303 LEU F CA  1 
ATOM   1847 C C   . LEU A 1 268 ? 174.57700 321.16700 15.73200  1.000 27.96955  ? 303 LEU F C   1 
ATOM   1848 O O   . LEU A 1 268 ? 175.43900 320.43900 16.24600  1.000 27.05507  ? 303 LEU F O   1 
ATOM   1849 C CB  . LEU A 1 268 ? 172.81400 319.92500 14.49900  1.000 23.16355  ? 303 LEU F CB  1 
ATOM   1850 C CG  . LEU A 1 268 ? 172.04300 319.57900 13.21800  1.000 31.40106  ? 303 LEU F CG  1 
ATOM   1851 C CD1 . LEU A 1 268 ? 172.51500 318.28900 12.61400  1.000 38.67129  ? 303 LEU F CD1 1 
ATOM   1852 C CD2 . LEU A 1 268 ? 170.57600 319.49000 13.57200  1.000 36.83359  ? 303 LEU F CD2 1 
ATOM   1853 N N   . PRO A 1 269 ? 174.02900 322.19400 16.38800  1.000 28.25632  ? 304 PRO F N   1 
ATOM   1854 C CA  . PRO A 1 269 ? 174.59000 322.63700 17.67000  1.000 21.48528  ? 304 PRO F CA  1 
ATOM   1855 C C   . PRO A 1 269 ? 174.21300 321.67500 18.78000  1.000 25.12520  ? 304 PRO F C   1 
ATOM   1856 O O   . PRO A 1 269 ? 173.10700 321.12800 18.81500  1.000 20.33071  ? 304 PRO F O   1 
ATOM   1857 C CB  . PRO A 1 269 ? 173.91500 323.99500 17.91400  1.000 17.98287  ? 304 PRO F CB  1 
ATOM   1858 C CG  . PRO A 1 269 ? 172.57700 323.85800 17.20900  1.000 19.81335  ? 304 PRO F CG  1 
ATOM   1859 C CD  . PRO A 1 269 ? 172.86700 323.00900 15.97900  1.000 24.18799  ? 304 PRO F CD  1 
ATOM   1860 N N   . LEU A 1 270 ? 175.15300 321.48600 19.70200  1.000 22.07227  ? 305 LEU F N   1 
ATOM   1861 C CA  . LEU A 1 270 ? 174.92800 320.75700 20.93400  1.000 20.31033  ? 305 LEU F CA  1 
ATOM   1862 C C   . LEU A 1 270 ? 175.05300 321.82200 22.00800  1.000 17.93750  ? 305 LEU F C   1 
ATOM   1863 O O   . LEU A 1 270 ? 176.11900 322.44200 22.14700  1.000 20.91257  ? 305 LEU F O   1 
ATOM   1864 C CB  . LEU A 1 270 ? 175.94400 319.62800 21.10900  1.000 26.19521  ? 305 LEU F CB  1 
ATOM   1865 C CG  . LEU A 1 270 ? 175.71600 318.41100 20.20800  1.000 24.94486  ? 305 LEU F CG  1 
ATOM   1866 C CD1 . LEU A 1 270 ? 176.76700 317.33600 20.52500  1.000 23.36614  ? 305 LEU F CD1 1 
ATOM   1867 C CD2 . LEU A 1 270 ? 174.30600 317.86700 20.38300  1.000 24.72973  ? 305 LEU F CD2 1 
ATOM   1868 N N   . TYR A 1 271 ? 173.98700 321.99800 22.78500  1.000 15.30505  ? 306 TYR F N   1 
ATOM   1869 C CA  . TYR A 1 271 ? 173.93600 323.05900 23.79200  1.000 22.32984  ? 306 TYR F CA  1 
ATOM   1870 C C   . TYR A 1 271 ? 174.38700 322.46500 25.11500  1.000 17.76432  ? 306 TYR F C   1 
ATOM   1871 O O   . TYR A 1 271 ? 173.61200 321.87700 25.85800  1.000 20.80313  ? 306 TYR F O   1 
ATOM   1872 C CB  . TYR A 1 271 ? 172.52000 323.64700 23.88200  1.000 19.75646  ? 306 TYR F CB  1 
ATOM   1873 C CG  . TYR A 1 271 ? 172.07100 324.27600 22.57200  1.000 22.05973  ? 306 TYR F CG  1 
ATOM   1874 C CD1 . TYR A 1 271 ? 172.49800 325.56100 22.23700  1.000 19.11072  ? 306 TYR F CD1 1 
ATOM   1875 C CD2 . TYR A 1 271 ? 171.20100 323.61400 21.68500  1.000 18.13689  ? 306 TYR F CD2 1 
ATOM   1876 C CE1 . TYR A 1 271 ? 172.12300 326.17100 21.05200  1.000 18.78500  ? 306 TYR F CE1 1 
ATOM   1877 C CE2 . TYR A 1 271 ? 170.81900 324.22500 20.48800  1.000 16.45829  ? 306 TYR F CE2 1 
ATOM   1878 C CZ  . TYR A 1 271 ? 171.28400 325.49800 20.18400  1.000 19.92143  ? 306 TYR F CZ  1 
ATOM   1879 O OH  . TYR A 1 271 ? 170.93600 326.12800 19.02600  1.000 21.33777  ? 306 TYR F OH  1 
ATOM   1880 N N   . GLY A 1 272 ? 175.70000 322.57800 25.34900  1.000 21.53470  ? 307 GLY F N   1 
ATOM   1881 C CA  . GLY A 1 272 ? 176.36000 322.14600 26.56300  1.000 19.67474  ? 307 GLY F CA  1 
ATOM   1882 C C   . GLY A 1 272 ? 176.07900 322.97700 27.79000  1.000 24.62653  ? 307 GLY F C   1 
ATOM   1883 O O   . GLY A 1 272 ? 176.36900 322.50600 28.89600  1.000 22.64901  ? 307 GLY F O   1 
ATOM   1884 N N   . VAL A 1 273 ? 175.65000 324.23600 27.64200  1.000 21.18468  ? 308 VAL F N   1 
ATOM   1885 C CA  . VAL A 1 273 ? 175.28000 325.03200 28.81800  1.000 16.58565  ? 308 VAL F CA  1 
ATOM   1886 C C   . VAL A 1 273 ? 173.78400 325.24800 28.78300  1.000 22.91405  ? 308 VAL F C   1 
ATOM   1887 O O   . VAL A 1 273 ? 173.26300 325.86900 27.84500  1.000 19.78109  ? 308 VAL F O   1 
ATOM   1888 C CB  . VAL A 1 273 ? 176.04300 326.35600 28.91600  1.000 16.69315  ? 308 VAL F CB  1 
ATOM   1889 C CG1 . VAL A 1 273 ? 175.86400 326.91300 30.29100  1.000 18.44925  ? 308 VAL F CG1 1 
ATOM   1890 C CG2 . VAL A 1 273 ? 177.52100 326.05600 28.78500  1.000 9.97568   ? 308 VAL F CG2 1 
ATOM   1891 N N   . ILE A 1 274 ? 173.09800 324.70400 29.77900  1.000 18.08174  ? 309 ILE F N   1 
ATOM   1892 C CA  . ILE A 1 274 ? 171.65100 324.79200 29.86100  1.000 20.06427  ? 309 ILE F CA  1 
ATOM   1893 C C   . ILE A 1 274 ? 171.16300 325.22900 31.22500  1.000 22.78268  ? 309 ILE F C   1 
ATOM   1894 O O   . ILE A 1 274 ? 171.58000 324.68500 32.24800  1.000 23.11167  ? 309 ILE F O   1 
ATOM   1895 C CB  . ILE A 1 274 ? 170.99900 323.44000 29.50300  1.000 25.24901  ? 309 ILE F CB  1 
ATOM   1896 C CG1 . ILE A 1 274 ? 171.39900 323.03500 28.10100  1.000 25.68167  ? 309 ILE F CG1 1 
ATOM   1897 C CG2 . ILE A 1 274 ? 169.49600 323.47400 29.71400  1.000 31.20781  ? 309 ILE F CG2 1 
ATOM   1898 C CD1 . ILE A 1 274 ? 170.36500 323.55700 27.11100  1.000 28.25977  ? 309 ILE F CD1 1 
ATOM   1899 N N   . ASP A 1 275 ? 170.17300 326.11300 31.20900  1.000 20.57882  ? 310 ASP F N   1 
ATOM   1900 C CA  . ASP A 1 275 ? 169.46400 326.64400 32.36700  1.000 18.75911  ? 310 ASP F CA  1 
ATOM   1901 C C   . ASP A 1 275 ? 170.34400 327.35000 33.39600  1.000 23.08775  ? 310 ASP F C   1 
ATOM   1902 O O   . ASP A 1 275 ? 169.99600 327.38200 34.58000  1.000 26.16630  ? 310 ASP F O   1 
ATOM   1903 C CB  . ASP A 1 275 ? 168.73300 325.49500 33.07000  1.000 20.97519  ? 310 ASP F CB  1 
ATOM   1904 C CG  . ASP A 1 275 ? 167.46200 325.07000 32.33900  1.000 28.96779  ? 310 ASP F CG  1 
ATOM   1905 O OD1 . ASP A 1 275 ? 167.10300 325.68200 31.30700  1.000 29.42995  ? 310 ASP F OD1 1 
ATOM   1906 O OD2 . ASP A 1 275 ? 166.84900 324.07100 32.76400  1.000 39.43963  ? 310 ASP F OD2 1 
ATOM   1907 N N   . THR A 1 276 ? 171.36700 328.00500 32.98400  1.000 19.54636  ? 311 THR F N   1 
ATOM   1908 C CA  . THR A 1 276 ? 172.20600 328.84300 33.84100  1.000 19.88997  ? 311 THR F CA  1 
ATOM   1909 C C   . THR A 1 276 ? 171.63200 330.25000 33.74800  1.000 19.03407  ? 311 THR F C   1 
ATOM   1910 O O   . THR A 1 276 ? 170.91300 330.55500 32.79200  1.000 19.20470  ? 311 THR F O   1 
ATOM   1911 C CB  . THR A 1 276 ? 173.68500 328.84600 33.49200  1.000 16.91985  ? 311 THR F CB  1 
ATOM   1912 O OG1 . THR A 1 276 ? 173.89000 329.46600 32.22200  1.000 15.19063  ? 311 THR F OG1 1 
ATOM   1913 C CG2 . THR A 1 276 ? 174.28400 327.42800 33.56600  1.000 18.28663  ? 311 THR F CG2 1 
ATOM   1914 N N   . PRO A 1 277 ? 171.73400 331.03900 34.79700  1.000 16.72568  ? 312 PRO F N   1 
ATOM   1915 C CA  . PRO A 1 277 ? 171.21600 332.41400 34.74700  1.000 21.37992  ? 312 PRO F CA  1 
ATOM   1916 C C   . PRO A 1 277 ? 171.87000 333.26700 33.65700  1.000 19.33019  ? 312 PRO F C   1 
ATOM   1917 O O   . PRO A 1 277 ? 173.08700 333.24800 33.45800  1.000 20.54270  ? 312 PRO F O   1 
ATOM   1918 C CB  . PRO A 1 277 ? 171.56900 332.97600 36.13200  1.000 19.68290  ? 312 PRO F CB  1 
ATOM   1919 C CG  . PRO A 1 277 ? 171.72400 331.74700 37.02900  1.000 21.92124  ? 312 PRO F CG  1 
ATOM   1920 C CD  . PRO A 1 277 ? 172.30500 330.68800 36.11500  1.000 18.44379  ? 312 PRO F CD  1 
ATOM   1921 N N   . CYS A 1 278 ? 171.04100 334.05100 32.97400  1.000 18.85764  ? 313 CYS F N   1 
ATOM   1922 C CA  . CYS A 1 278 ? 171.47400 334.96000 31.91700  1.000 18.87208  ? 313 CYS F CA  1 
ATOM   1923 C C   . CYS A 1 278 ? 170.77700 336.29200 32.18400  1.000 17.13496  ? 313 CYS F C   1 
ATOM   1924 O O   . CYS A 1 278 ? 169.67900 336.35000 32.74300  1.000 16.68538  ? 313 CYS F O   1 
ATOM   1925 C CB  . CYS A 1 278 ? 171.05300 334.51200 30.50300  1.000 16.81754  ? 313 CYS F CB  1 
ATOM   1926 S SG  . CYS A 1 278 ? 171.87600 333.07000 29.78700  1.000 26.07366  ? 313 CYS F SG  1 
ATOM   1927 N N   . TRP A 1 279 ? 171.45900 337.37300 31.85300  1.000 16.00852  ? 314 TRP F N   1 
ATOM   1928 C CA  . TRP A 1 279 ? 170.91300 338.70500 32.05400  1.000 17.23099  ? 314 TRP F CA  1 
ATOM   1929 C C   . TRP A 1 279 ? 171.45300 339.62400 30.95900  1.000 17.66133  ? 314 TRP F C   1 
ATOM   1930 O O   . TRP A 1 279 ? 172.52000 339.38800 30.39100  1.000 16.17856  ? 314 TRP F O   1 
ATOM   1931 C CB  . TRP A 1 279 ? 171.24300 339.25000 33.45500  1.000 15.04730  ? 314 TRP F CB  1 
ATOM   1932 C CG  . TRP A 1 279 ? 172.73000 339.42700 33.73800  1.000 14.04518  ? 314 TRP F CG  1 
ATOM   1933 C CD1 . TRP A 1 279 ? 173.46600 340.60400 33.63900  1.000 16.67023  ? 314 TRP F CD1 1 
ATOM   1934 C CD2 . TRP A 1 279 ? 173.65300 338.42100 34.18900  1.000 13.72942  ? 314 TRP F CD2 1 
ATOM   1935 N NE1 . TRP A 1 279 ? 174.78000 340.36900 33.98700  1.000 16.61785  ? 314 TRP F NE1 1 
ATOM   1936 C CE2 . TRP A 1 279 ? 174.92200 339.04500 34.33000  1.000 16.47117  ? 314 TRP F CE2 1 
ATOM   1937 C CE3 . TRP A 1 279 ? 173.53500 337.05500 34.48700  1.000 19.78577  ? 314 TRP F CE3 1 
ATOM   1938 C CZ2 . TRP A 1 279 ? 176.05600 338.34500 34.73100  1.000 16.04503  ? 314 TRP F CZ2 1 
ATOM   1939 C CZ3 . TRP A 1 279 ? 174.67000 336.35900 34.90600  1.000 18.93210  ? 314 TRP F CZ3 1 
ATOM   1940 C CH2 . TRP A 1 279 ? 175.90900 337.00400 35.02300  1.000 18.99619  ? 314 TRP F CH2 1 
ATOM   1941 N N   . LYS A 1 280 ? 170.69400 340.67100 30.65700  1.000 14.28229  ? 315 LYS F N   1 
ATOM   1942 C CA  . LYS A 1 280 ? 171.06500 341.60500 29.60700  1.000 16.64428  ? 315 LYS F CA  1 
ATOM   1943 C C   . LYS A 1 280 ? 171.29800 342.98600 30.20800  1.000 14.62997  ? 315 LYS F C   1 
ATOM   1944 O O   . LYS A 1 280 ? 170.45900 343.47000 30.97300  1.000 14.81469  ? 315 LYS F O   1 
ATOM   1945 C CB  . LYS A 1 280 ? 169.99200 341.67500 28.51800  1.000 18.07369  ? 315 LYS F CB  1 
ATOM   1946 C CG  . LYS A 1 280 ? 170.45900 342.47000 27.32500  1.000 15.10656  ? 315 LYS F CG  1 
ATOM   1947 C CD  . LYS A 1 280 ? 169.51300 342.31200 26.15700  1.000 19.05234  ? 315 LYS F CD  1 
ATOM   1948 C CE  . LYS A 1 280 ? 170.12700 342.97200 24.91100  1.000 20.49131  ? 315 LYS F CE  1 
ATOM   1949 N NZ  . LYS A 1 280 ? 169.27400 342.77600 23.72400  1.000 30.00340  ? 315 LYS F NZ  1 
ATOM   1950 N N   . LEU A 1 281 ? 172.49300 343.53500 29.98800  1.000 10.05910  ? 316 LEU F N   1 
ATOM   1951 C CA  . LEU A 1 281 ? 172.86700 344.86000 30.47900  1.000 14.04158  ? 316 LEU F CA  1 
ATOM   1952 C C   . LEU A 1 281 ? 172.55300 345.89400 29.39300  1.000 14.80400  ? 316 LEU F C   1 
ATOM   1953 O O   . LEU A 1 281 ? 172.97200 345.72400 28.23200  1.000 13.77991  ? 316 LEU F O   1 
ATOM   1954 C CB  . LEU A 1 281 ? 174.35000 344.89500 30.85200  1.000 12.41242  ? 316 LEU F CB  1 
ATOM   1955 C CG  . LEU A 1 281 ? 174.99200 346.23100 31.21900  1.000 13.98758  ? 316 LEU F CG  1 
ATOM   1956 C CD1 . LEU A 1 281 ? 174.35800 346.81200 32.45500  1.000 13.01707  ? 316 LEU F CD1 1 
ATOM   1957 C CD2 . LEU A 1 281 ? 176.52400 346.12500 31.38000  1.000 15.88186  ? 316 LEU F CD2 1 
ATOM   1958 N N   . HIS A 1 282 ? 171.84400 346.96800 29.77700  1.000 14.33622  ? 317 HIS F N   1 
ATOM   1959 C CA  . HIS A 1 282 ? 171.49900 348.09500 28.91100  1.000 14.09189  ? 317 HIS F CA  1 
ATOM   1960 C C   . HIS A 1 282 ? 172.15900 349.35100 29.47100  1.000 15.80452  ? 317 HIS F C   1 
ATOM   1961 O O   . HIS A 1 282 ? 172.13100 349.55400 30.68800  1.000 15.54635  ? 317 HIS F O   1 
ATOM   1962 C CB  . HIS A 1 282 ? 169.98900 348.33200 28.95300  1.000 14.85840  ? 317 HIS F CB  1 
ATOM   1963 C CG  . HIS A 1 282 ? 169.17500 347.11500 28.66100  1.000 14.54792  ? 317 HIS F CG  1 
ATOM   1964 N ND1 . HIS A 1 282 ? 168.75400 346.75700 27.39900  1.000 19.12727  ? 317 HIS F ND1 1 
ATOM   1965 C CD2 . HIS A 1 282 ? 168.64200 346.19800 29.51100  1.000 15.50522  ? 317 HIS F CD2 1 
ATOM   1966 C CE1 . HIS A 1 282 ? 168.03500 345.64400 27.47800  1.000 14.66283  ? 317 HIS F CE1 1 
ATOM   1967 N NE2 . HIS A 1 282 ? 167.93900 345.29600 28.74900  1.000 15.06609  ? 317 HIS F NE2 1 
ATOM   1968 N N   . THR A 1 283 ? 172.81700 350.14800 28.63300  1.000 12.74134  ? 318 THR F N   1 
ATOM   1969 C CA  . THR A 1 283 ? 173.50800 351.34300 29.12000  1.000 13.11669  ? 318 THR F CA  1 
ATOM   1970 C C   . THR A 1 283 ? 173.10100 352.57300 28.31600  1.000 17.42101  ? 318 THR F C   1 
ATOM   1971 O O   . THR A 1 283 ? 172.68100 352.45800 27.16300  1.000 17.76045  ? 318 THR F O   1 
ATOM   1972 C CB  . THR A 1 283 ? 175.04000 351.20900 29.07000  1.000 17.77275  ? 318 THR F CB  1 
ATOM   1973 O OG1 . THR A 1 283 ? 175.44300 351.11000 27.70900  1.000 18.58556  ? 318 THR F OG1 1 
ATOM   1974 C CG2 . THR A 1 283 ? 175.48700 349.93300 29.80700  1.000 12.02796  ? 318 THR F CG2 1 
ATOM   1975 N N   . SER A 1 284 ? 173.20100 353.75300 28.93300  1.000 13.19082  ? 319 SER F N   1 
ATOM   1976 C CA  . SER A 1 284 ? 172.83800 354.98800 28.25800  1.000 16.02366  ? 319 SER F CA  1 
ATOM   1977 C C   . SER A 1 284 ? 173.69500 356.12300 28.82300  1.000 13.99897  ? 319 SER F C   1 
ATOM   1978 O O   . SER A 1 284 ? 174.13500 356.03700 29.97400  1.000 16.07605  ? 319 SER F O   1 
ATOM   1979 C CB  . SER A 1 284 ? 171.33300 355.24000 28.40200  1.000 17.77311  ? 319 SER F CB  1 
ATOM   1980 O OG  . SER A 1 284 ? 170.88300 356.25100 27.54400  1.000 23.23471  ? 319 SER F OG  1 
ATOM   1981 N N   . PRO A 1 285 ? 173.98600 357.16300 28.04300  1.000 17.27380  ? 320 PRO F N   1 
ATOM   1982 C CA  . PRO A 1 285 ? 174.88100 358.22400 28.53900  1.000 16.21841  ? 320 PRO F CA  1 
ATOM   1983 C C   . PRO A 1 285 ? 174.33400 358.93400 29.77100  1.000 17.33736  ? 320 PRO F C   1 
ATOM   1984 O O   . PRO A 1 285 ? 173.17800 359.36100 29.81500  1.000 16.63633  ? 320 PRO F O   1 
ATOM   1985 C CB  . PRO A 1 285 ? 174.98500 359.19400 27.35400  1.000 18.99954  ? 320 PRO F CB  1 
ATOM   1986 C CG  . PRO A 1 285 ? 174.68600 358.36600 26.13900  1.000 22.58106  ? 320 PRO F CG  1 
ATOM   1987 C CD  . PRO A 1 285 ? 173.63300 357.35700 26.62100  1.000 21.29224  ? 320 PRO F CD  1 
ATOM   1988 N N   . LEU A 1 286 ? 175.23100 359.19000 30.70700  1.000 16.21899  ? 321 LEU F N   1 
ATOM   1989 C CA  . LEU A 1 286 ? 174.96000 359.86800 31.97200  1.000 15.65491  ? 321 LEU F CA  1 
ATOM   1990 C C   . LEU A 1 286 ? 175.73800 361.17300 32.02400  1.000 19.17099  ? 321 LEU F C   1 
ATOM   1991 O O   . LEU A 1 286 ? 176.96200 361.15200 32.15100  1.000 16.02028  ? 321 LEU F O   1 
ATOM   1992 C CB  . LEU A 1 286 ? 175.38100 359.00100 33.15300  1.000 16.80325  ? 321 LEU F CB  1 
ATOM   1993 C CG  . LEU A 1 286 ? 175.11200 359.64100 34.50700  1.000 15.73504  ? 321 LEU F CG  1 
ATOM   1994 C CD1 . LEU A 1 286 ? 173.63500 359.72900 34.75400  1.000 20.95169  ? 321 LEU F CD1 1 
ATOM   1995 C CD2 . LEU A 1 286 ? 175.82800 358.85900 35.62100  1.000 15.85181  ? 321 LEU F CD2 1 
ATOM   1996 N N   . CYS A 1 287 ? 175.07100 362.29400 31.77200  1.000 18.54509  ? 322 CYS F N   1 
ATOM   1997 C CA  . CYS A 1 287 ? 175.76000 363.57300 31.76900  1.000 17.59343  ? 322 CYS F CA  1 
ATOM   1998 C C   . CYS A 1 287 ? 175.30700 364.46200 32.92200  1.000 21.95478  ? 322 CYS F C   1 
ATOM   1999 O O   . CYS A 1 287 ? 174.19900 364.32200 33.45000  1.000 20.11670  ? 322 CYS F O   1 
ATOM   2000 C CB  . CYS A 1 287 ? 175.51400 364.30800 30.44700  1.000 18.82517  ? 322 CYS F CB  1 
ATOM   2001 S SG  . CYS A 1 287 ? 175.90600 363.39000 28.94500  1.000 22.24475  ? 322 CYS F SG  1 
ATOM   2002 N N   . THR A 1 288 ? 176.09100 365.51400 33.16200  1.000 19.68706  ? 323 THR F N   1 
ATOM   2003 C CA  . THR A 1 288 ? 175.62400 366.48900 34.11000  1.000 22.13153  ? 323 THR F CA  1 
ATOM   2004 C C   . THR A 1 288 ? 174.71100 367.41300 33.32800  1.000 23.51934  ? 323 THR F C   1 
ATOM   2005 O O   . THR A 1 288 ? 174.75300 367.46300 32.09400  1.000 21.89018  ? 323 THR F O   1 
ATOM   2006 C CB  . THR A 1 288 ? 176.78100 367.31800 34.72000  1.000 25.63269  ? 323 THR F CB  1 
ATOM   2007 O OG1 . THR A 1 288 ? 177.58200 367.91000 33.67900  1.000 21.30043  ? 323 THR F OG1 1 
ATOM   2008 C CG2 . THR A 1 288 ? 177.64400 366.52600 35.67800  1.000 22.86330  ? 323 THR F CG2 1 
ATOM   2009 N N   . THR A 1 289 ? 173.85600 368.11600 34.05300  1.000 27.80917  ? 324 THR F N   1 
ATOM   2010 C CA  . THR A 1 289 ? 172.80400 368.92200 33.43600  1.000 35.01024  ? 324 THR F CA  1 
ATOM   2011 C C   . THR A 1 289 ? 172.99100 370.39900 33.73200  1.000 38.09011  ? 324 THR F C   1 
ATOM   2012 O O   . THR A 1 289 ? 172.02400 371.10100 34.04300  1.000 40.58837  ? 324 THR F O   1 
ATOM   2013 C CB  . THR A 1 289 ? 171.43200 368.42900 33.87500  1.000 24.01373  ? 324 THR F CB  1 
ATOM   2014 O OG1 . THR A 1 289 ? 171.37700 368.47900 35.30100  1.000 29.78366  ? 324 THR F OG1 1 
ATOM   2015 C CG2 . THR A 1 289 ? 171.16900 367.00300 33.34400  1.000 23.40142  ? 324 THR F CG2 1 
ATOM   2016 N N   . ASN A 1 290 ? 174.19500 370.90800 33.53900  1.000 39.65932  ? 325 ASN F N   1 
ATOM   2017 C CA  . ASN A 1 290 ? 174.34000 372.33500 33.70000  1.000 40.85132  ? 325 ASN F CA  1 
ATOM   2018 C C   . ASN A 1 290 ? 173.68300 373.01500 32.50800  1.000 49.74000  ? 325 ASN F C   1 
ATOM   2019 O O   . ASN A 1 290 ? 173.64000 372.46700 31.40200  1.000 46.14985  ? 325 ASN F O   1 
ATOM   2020 C CB  . ASN A 1 290 ? 175.83700 372.64300 33.73400  1.000 46.71030  ? 325 ASN F CB  1 
ATOM   2021 C CG  . ASN A 1 290 ? 176.41300 372.51900 35.12900  1.000 45.53412  ? 325 ASN F CG  1 
ATOM   2022 O OD1 . ASN A 1 290 ? 175.67300 372.26600 36.07900  1.000 47.66065  ? 325 ASN F OD1 1 
ATOM   2023 N ND2 . ASN A 1 290 ? 177.74300 372.53300 35.23600  1.000 51.59036  ? 325 ASN F ND2 1 
ATOM   2024 N N   . THR A 1 291 ? 173.28900 374.27300 32.69700  1.000 54.75949  ? 326 THR F N   1 
ATOM   2025 C CA  . THR A 1 291 ? 172.50200 374.99300 31.69100  1.000 55.23686  ? 326 THR F CA  1 
ATOM   2026 C C   . THR A 1 291 ? 173.34700 375.73200 30.67400  1.000 63.29363  ? 326 THR F C   1 
ATOM   2027 O O   . THR A 1 291 ? 172.80900 376.18400 29.65500  1.000 68.06122  ? 326 THR F O   1 
ATOM   2028 C CB  . THR A 1 291 ? 171.51700 375.97700 32.31100  1.000 60.11616  ? 326 THR F CB  1 
ATOM   2029 O OG1 . THR A 1 291 ? 170.66400 376.46600 31.26200  1.000 67.50033  ? 326 THR F OG1 1 
ATOM   2030 C CG2 . THR A 1 291 ? 172.27100 377.10100 33.01300  1.000 52.58501  ? 326 THR F CG2 1 
ATOM   2031 N N   . LYS A 1 292 ? 174.65300 375.73100 30.85900  1.000 57.44737  ? 327 LYS F N   1 
ATOM   2032 C CA  . LYS A 1 292 ? 175.60800 376.42000 30.01200  1.000 61.20758  ? 327 LYS F CA  1 
ATOM   2033 C C   . LYS A 1 292 ? 176.42600 375.35700 29.28800  1.000 70.01409  ? 327 LYS F C   1 
ATOM   2034 O O   . LYS A 1 292 ? 177.11600 374.54800 29.92700  1.000 62.47283  ? 327 LYS F O   1 
ATOM   2035 C CB  . LYS A 1 292 ? 176.52200 377.28200 30.87100  1.000 60.73592  ? 327 LYS F CB  1 
ATOM   2036 C CG  . LYS A 1 292 ? 176.49700 376.80600 32.32000  1.000 61.10376  ? 327 LYS F CG  1 
ATOM   2037 C CD  . LYS A 1 292 ? 177.73900 377.24300 33.07800  1.000 66.13368  ? 327 LYS F CD  1 
ATOM   2038 C CE  . LYS A 1 292 ? 177.73700 376.68300 34.49200  1.000 65.84795  ? 327 LYS F CE  1 
ATOM   2039 N NZ  . LYS A 1 292 ? 179.06600 376.88600 35.14600  1.000 69.46397  ? 327 LYS F NZ  1 
ATOM   2040 N N   . GLU A 1 293 ? 176.31700 375.34800 27.95700  1.000 66.10548  ? 328 GLU F N   1 
ATOM   2041 C CA  . GLU A 1 293 ? 177.02600 374.38000 27.12600  1.000 73.47146  ? 328 GLU F CA  1 
ATOM   2042 C C   . GLU A 1 293 ? 178.54100 374.59400 27.15800  1.000 69.80988  ? 328 GLU F C   1 
ATOM   2043 O O   . GLU A 1 293 ? 179.02900 375.72300 27.27000  1.000 61.46129  ? 328 GLU F O   1 
ATOM   2044 C CB  . GLU A 1 293 ? 176.50900 374.48100 25.67800  1.000 72.83521  ? 328 GLU F CB  1 
ATOM   2045 C CG  . GLU A 1 293 ? 176.86900 373.31600 24.70200  1.000 70.23812  ? 328 GLU F CG  1 
ATOM   2046 C CD  . GLU A 1 293 ? 176.81900 373.75600 23.21100  1.000 70.63615  ? 328 GLU F CD  1 
ATOM   2047 O OE1 . GLU A 1 293 ? 177.21400 374.91700 22.93100  1.000 58.76907  ? 328 GLU F OE1 1 
ATOM   2048 O OE2 . GLU A 1 293 ? 176.41100 372.95400 22.31700  1.000 66.24144  ? 328 GLU F OE2 1 
ATOM   2049 N N   . GLY A 1 294 ? 179.28300 373.47600 27.19400  1.000 64.67655  ? 329 GLY F N   1 
ATOM   2050 C CA  . GLY A 1 294 ? 180.70400 373.50100 27.45000  1.000 53.07532  ? 329 GLY F CA  1 
ATOM   2051 C C   . GLY A 1 294 ? 181.09800 373.23700 28.87900  1.000 53.43737  ? 329 GLY F C   1 
ATOM   2052 O O   . GLY A 1 294 ? 182.29300 373.03000 29.15100  1.000 56.21579  ? 329 GLY F O   1 
ATOM   2053 N N   . SER A 1 295 ? 180.13000 373.14300 29.78600  1.000 46.10870  ? 330 SER F N   1 
ATOM   2054 C CA  . SER A 1 295 ? 180.42500 372.85500 31.18100  1.000 52.19032  ? 330 SER F CA  1 
ATOM   2055 C C   . SER A 1 295 ? 179.88100 371.51400 31.62600  1.000 39.06870  ? 330 SER F C   1 
ATOM   2056 O O   . SER A 1 295 ? 179.87200 371.22600 32.82700  1.000 43.85228  ? 330 SER F O   1 
ATOM   2057 C CB  . SER A 1 295 ? 179.86700 373.95900 32.08200  1.000 55.38081  ? 330 SER F CB  1 
ATOM   2058 O OG  . SER A 1 295 ? 178.45100 374.01000 32.00600  1.000 53.84007  ? 330 SER F OG  1 
ATOM   2059 N N   . ASN A 1 296 ? 179.54300 370.63800 30.69500  1.000 34.04874  ? 331 ASN F N   1 
ATOM   2060 C CA  . ASN A 1 296 ? 178.94000 369.39200 31.11500  1.000 34.93393  ? 331 ASN F CA  1 
ATOM   2061 C C   . ASN A 1 296 ? 179.87400 368.23900 30.77700  1.000 32.07796  ? 331 ASN F C   1 
ATOM   2062 O O   . ASN A 1 296 ? 180.59200 368.25800 29.77000  1.000 33.48567  ? 331 ASN F O   1 
ATOM   2063 C CB  . ASN A 1 296 ? 177.61800 369.19900 30.38500  1.000 26.29827  ? 331 ASN F CB  1 
ATOM   2064 C CG  . ASN A 1 296 ? 176.49700 369.97900 31.03400  1.000 33.04760  ? 331 ASN F CG  1 
ATOM   2065 O OD1 . ASN A 1 296 ? 176.33500 369.99000 32.25900  1.000 28.44247  ? 331 ASN F OD1 1 
ATOM   2066 N ND2 . ASN A 1 296 ? 175.70900 370.63400 30.20900  1.000 31.49052  ? 331 ASN F ND2 1 
ATOM   2067 N N   . ILE A 1 297 ? 179.86200 367.23800 31.63500  1.000 25.98952  ? 332 ILE F N   1 
ATOM   2068 C CA  . ILE A 1 297 ? 180.68200 366.05600 31.42800  1.000 23.29279  ? 332 ILE F CA  1 
ATOM   2069 C C   . ILE A 1 297 ? 179.77800 364.83900 31.39400  1.000 23.25402  ? 332 ILE F C   1 
ATOM   2070 O O   . ILE A 1 297 ? 178.66400 364.85500 31.93200  1.000 21.92178  ? 332 ILE F O   1 
ATOM   2071 C CB  . ILE A 1 297 ? 181.76300 365.91100 32.50200  1.000 20.76331  ? 332 ILE F CB  1 
ATOM   2072 C CG1 . ILE A 1 297 ? 181.10900 365.90500 33.86300  1.000 16.91176  ? 332 ILE F CG1 1 
ATOM   2073 C CG2 . ILE A 1 297 ? 182.82900 366.98100 32.32400  1.000 25.18026  ? 332 ILE F CG2 1 
ATOM   2074 C CD1 . ILE A 1 297 ? 182.11200 365.75700 34.98100  1.000 20.65374  ? 332 ILE F CD1 1 
ATOM   2075 N N   . CYS A 1 298 ? 180.25100 363.80100 30.74700  1.000 17.70231  ? 333 CYS F N   1 
ATOM   2076 C CA  . CYS A 1 298 ? 179.45900 362.61300 30.57800  1.000 18.44111  ? 333 CYS F CA  1 
ATOM   2077 C C   . CYS A 1 298 ? 180.22700 361.32600 30.74600  1.000 20.47397  ? 333 CYS F C   1 
ATOM   2078 O O   . CYS A 1 298 ? 181.43000 361.30200 30.62800  1.000 18.72288  ? 333 CYS F O   1 
ATOM   2079 C CB  . CYS A 1 298 ? 178.80800 362.59900 29.19100  1.000 24.55205  ? 333 CYS F CB  1 
ATOM   2080 S SG  . CYS A 1 298 ? 177.81600 363.99300 28.62900  1.000 27.96745  ? 333 CYS F SG  1 
ATOM   2081 N N   . LEU A 1 299 ? 179.51500 360.26300 31.04500  1.000 16.69852  ? 334 LEU F N   1 
ATOM   2082 C CA  . LEU A 1 299 ? 180.08500 358.95700 31.14400  1.000 14.88628  ? 334 LEU F CA  1 
ATOM   2083 C C   . LEU A 1 299 ? 179.04200 357.96200 30.70800  1.000 17.97704  ? 334 LEU F C   1 
ATOM   2084 O O   . LEU A 1 299 ? 177.86400 358.17900 30.87500  1.000 17.39539  ? 334 LEU F O   1 
ATOM   2085 C CB  . LEU A 1 299 ? 180.58000 358.62100 32.55100  1.000 15.95532  ? 334 LEU F CB  1 
ATOM   2086 C CG  . LEU A 1 299 ? 179.74600 358.37100 33.79300  1.000 23.15295  ? 334 LEU F CG  1 
ATOM   2087 C CD1 . LEU A 1 299 ? 179.15900 356.97200 33.79700  1.000 19.21720  ? 334 LEU F CD1 1 
ATOM   2088 C CD2 . LEU A 1 299 ? 180.67100 358.56100 34.98400  1.000 20.82848  ? 334 LEU F CD2 1 
ATOM   2089 N N   . THR A 1 300 ? 179.49700 356.87100 30.14200  1.000 14.37504  ? 335 THR F N   1 
ATOM   2090 C CA  . THR A 1 300 ? 178.61500 355.82400 29.70800  1.000 17.05997  ? 335 THR F CA  1 
ATOM   2091 C C   . THR A 1 300 ? 179.24700 354.46400 30.03900  1.000 18.83235  ? 335 THR F C   1 
ATOM   2092 O O   . THR A 1 300 ? 180.39600 354.23300 29.70900  1.000 14.86480  ? 335 THR F O   1 
ATOM   2093 C CB  . THR A 1 300 ? 178.26000 355.92100 28.19600  1.000 16.23521  ? 335 THR F CB  1 
ATOM   2094 O OG1 . THR A 1 300 ? 177.87500 357.25100 27.85500  1.000 18.40932  ? 335 THR F OG1 1 
ATOM   2095 C CG2 . THR A 1 300 ? 177.13000 354.97000 27.88400  1.000 14.51205  ? 335 THR F CG2 1 
ATOM   2096 N N   . ARG A 1 301 ? 178.51300 353.58500 30.70900  1.000 14.98668  ? 336 ARG F N   1 
ATOM   2097 C CA  . ARG A 1 301 ? 179.02700 352.24000 30.94100  1.000 16.56344  ? 336 ARG F CA  1 
ATOM   2098 C C   . ARG A 1 301 ? 179.18200 351.54400 29.60100  1.000 17.97515  ? 336 ARG F C   1 
ATOM   2099 O O   . ARG A 1 301 ? 178.32300 351.66100 28.72700  1.000 18.48430  ? 336 ARG F O   1 
ATOM   2100 C CB  . ARG A 1 301 ? 178.10400 351.42600 31.86000  1.000 15.66219  ? 336 ARG F CB  1 
ATOM   2101 C CG  . ARG A 1 301 ? 178.08300 351.86100 33.35200  1.000 13.35156  ? 336 ARG F CG  1 
ATOM   2102 C CD  . ARG A 1 301 ? 177.20200 350.90600 34.12000  1.000 15.78443  ? 336 ARG F CD  1 
ATOM   2103 N NE  . ARG A 1 301 ? 177.67400 349.53200 34.04000  1.000 13.27670  ? 336 ARG F NE  1 
ATOM   2104 C CZ  . ARG A 1 301 ? 177.03300 348.50200 34.57500  1.000 19.86392  ? 336 ARG F CZ  1 
ATOM   2105 N NH1 . ARG A 1 301 ? 175.87700 348.66700 35.21800  1.000 15.18250  ? 336 ARG F NH1 1 
ATOM   2106 N NH2 . ARG A 1 301 ? 177.55300 347.27400 34.45300  1.000 16.25636  ? 336 ARG F NH2 1 
ATOM   2107 N N   . THR A 1 302 ? 180.23100 350.75300 29.46600  1.000 18.32218  ? 337 THR F N   1 
ATOM   2108 C CA  . THR A 1 302 ? 180.46200 350.03500 28.22800  1.000 20.21294  ? 337 THR F CA  1 
ATOM   2109 C C   . THR A 1 302 ? 180.12500 348.56300 28.48200  1.000 19.11396  ? 337 THR F C   1 
ATOM   2110 O O   . THR A 1 302 ? 179.64000 348.15500 29.54900  1.000 22.53501  ? 337 THR F O   1 
ATOM   2111 C CB  . THR A 1 302 ? 181.89900 350.21100 27.71000  1.000 22.37685  ? 337 THR F CB  1 
ATOM   2112 O OG1 . THR A 1 302 ? 182.81000 349.82100 28.72200  1.000 24.74947  ? 337 THR F OG1 1 
ATOM   2113 C CG2 . THR A 1 302 ? 182.18700 351.64800 27.33700  1.000 27.39197  ? 337 THR F CG2 1 
ATOM   2114 N N   . ASP A 1 303 ? 180.28000 347.76400 27.45300  1.000 16.51888  ? 338 ASP F N   1 
ATOM   2115 C CA  . ASP A 1 303 ? 179.98400 346.33200 27.54700  1.000 30.01266  ? 338 ASP F CA  1 
ATOM   2116 C C   . ASP A 1 303 ? 178.52200 346.05300 27.93100  1.000 28.89325  ? 338 ASP F C   1 
ATOM   2117 O O   . ASP A 1 303 ? 178.18300 345.22300 28.78700  1.000 22.07372  ? 338 ASP F O   1 
ATOM   2118 C CB  . ASP A 1 303 ? 180.94100 345.58400 28.49100  1.000 29.00169  ? 338 ASP F CB  1 
ATOM   2119 C CG  . ASP A 1 303 ? 182.41700 345.63500 28.01600  1.000 33.96164  ? 338 ASP F CG  1 
ATOM   2120 O OD1 . ASP A 1 303 ? 182.66000 345.72400 26.78100  1.000 35.96980  ? 338 ASP F OD1 1 
ATOM   2121 O OD2 . ASP A 1 303 ? 183.32000 345.46500 28.86900  1.000 33.11519  ? 338 ASP F OD2 1 
ATOM   2122 N N   . ARG A 1 304 ? 177.66500 346.60600 27.11400  1.000 21.49661  ? 339 ARG F N   1 
ATOM   2123 C CA  . ARG A 1 304 ? 176.26300 346.31200 27.18200  1.000 20.24377  ? 339 ARG F CA  1 
ATOM   2124 C C   . ARG A 1 304 ? 176.10000 345.07500 26.33500  1.000 16.63529  ? 339 ARG F C   1 
ATOM   2125 O O   . ARG A 1 304 ? 176.98800 344.77900 25.53500  1.000 15.07225  ? 339 ARG F O   1 
ATOM   2126 C CB  . ARG A 1 304 ? 175.46800 347.45100 26.57600  1.000 14.92351  ? 339 ARG F CB  1 
ATOM   2127 C CG  . ARG A 1 304 ? 175.83500 347.63600 25.09300  1.000 20.02236  ? 339 ARG F CG  1 
ATOM   2128 C CD  . ARG A 1 304 ? 174.79800 348.47600 24.40900  1.000 25.81195  ? 339 ARG F CD  1 
ATOM   2129 N NE  . ARG A 1 304 ? 174.89600 349.86600 24.85000  1.000 34.42304  ? 339 ARG F NE  1 
ATOM   2130 C CZ  . ARG A 1 304 ? 175.52500 350.86800 24.24900  1.000 45.44745  ? 339 ARG F CZ  1 
ATOM   2131 N NH1 . ARG A 1 304 ? 176.18200 350.69400 23.11000  1.000 45.03871  ? 339 ARG F NH1 1 
ATOM   2132 N NH2 . ARG A 1 304 ? 175.44200 352.09300 24.78400  1.000 33.42714  ? 339 ARG F NH2 1 
ATOM   2133 N N   . GLY A 1 305 ? 175.14700 344.23100 26.70400  1.000 13.73092  ? 340 GLY F N   1 
ATOM   2134 C CA  . GLY A 1 305 ? 174.87100 343.02200 25.94500  1.000 14.74865  ? 340 GLY F CA  1 
ATOM   2135 C C   . GLY A 1 305 ? 174.40000 341.88500 26.84300  1.000 15.17150  ? 340 GLY F C   1 
ATOM   2136 O O   . GLY A 1 305 ? 174.08700 342.10500 28.01600  1.000 12.16546  ? 340 GLY F O   1 
ATOM   2137 N N   . TRP A 1 306 ? 174.59900 340.65100 26.34900  1.000 15.86167  ? 341 TRP F N   1 
ATOM   2138 C CA  . TRP A 1 306 ? 174.13600 339.44900 27.05400  1.000 15.22457  ? 341 TRP F CA  1 
ATOM   2139 C C   . TRP A 1 306 ? 175.24800 338.84500 27.89100  1.000 13.26858  ? 341 TRP F C   1 
ATOM   2140 O O   . TRP A 1 306 ? 176.39900 338.80600 27.46000  1.000 13.62460  ? 341 TRP F O   1 
ATOM   2141 C CB  . TRP A 1 306 ? 173.54600 338.36500 26.15000  1.000 12.86036  ? 341 TRP F CB  1 
ATOM   2142 C CG  . TRP A 1 306 ? 172.12900 338.58700 25.76900  1.000 16.15805  ? 341 TRP F CG  1 
ATOM   2143 C CD1 . TRP A 1 306 ? 171.65200 339.03300 24.56400  1.000 16.00069  ? 341 TRP F CD1 1 
ATOM   2144 C CD2 . TRP A 1 306 ? 170.98100 338.42300 26.62600  1.000 14.77562  ? 341 TRP F CD2 1 
ATOM   2145 N NE1 . TRP A 1 306 ? 170.27800 339.13400 24.61400  1.000 19.49978  ? 341 TRP F NE1 1 
ATOM   2146 C CE2 . TRP A 1 306 ? 169.83600 338.75500 25.85700  1.000 16.68964  ? 341 TRP F CE2 1 
ATOM   2147 C CE3 . TRP A 1 306 ? 170.81200 338.03700 27.96800  1.000 15.80551  ? 341 TRP F CE3 1 
ATOM   2148 C CZ2 . TRP A 1 306 ? 168.52700 338.70100 26.37900  1.000 15.49308  ? 341 TRP F CZ2 1 
ATOM   2149 C CZ3 . TRP A 1 306 ? 169.50200 337.98200 28.49900  1.000 16.33039  ? 341 TRP F CZ3 1 
ATOM   2150 C CH2 . TRP A 1 306 ? 168.37400 338.31500 27.69000  1.000 16.45254  ? 341 TRP F CH2 1 
ATOM   2151 N N   . TYR A 1 307 ? 174.91400 338.50600 29.12700  1.000 15.05344  ? 342 TYR F N   1 
ATOM   2152 C CA  . TYR A 1 307 ? 175.75800 337.78600 30.07000  1.000 13.84600  ? 342 TYR F CA  1 
ATOM   2153 C C   . TYR A 1 307 ? 175.10800 336.48600 30.52900  1.000 17.09647  ? 342 TYR F C   1 
ATOM   2154 O O   . TYR A 1 307 ? 173.90500 336.45900 30.78400  1.000 16.31796  ? 342 TYR F O   1 
ATOM   2155 C CB  . TYR A 1 307 ? 176.04600 338.65600 31.29400  1.000 13.45534  ? 342 TYR F CB  1 
ATOM   2156 C CG  . TYR A 1 307 ? 176.84500 339.90000 30.98900  1.000 16.82271  ? 342 TYR F CG  1 
ATOM   2157 C CD1 . TYR A 1 307 ? 176.25700 341.00800 30.39400  1.000 16.92735  ? 342 TYR F CD1 1 
ATOM   2158 C CD2 . TYR A 1 307 ? 178.19200 339.97300 31.33000  1.000 12.59218  ? 342 TYR F CD2 1 
ATOM   2159 C CE1 . TYR A 1 307 ? 176.99600 342.15000 30.13400  1.000 17.33882  ? 342 TYR F CE1 1 
ATOM   2160 C CE2 . TYR A 1 307 ? 178.94900 341.10100 31.06100  1.000 18.05572  ? 342 TYR F CE2 1 
ATOM   2161 C CZ  . TYR A 1 307 ? 178.33800 342.18600 30.45200  1.000 19.56170  ? 342 TYR F CZ  1 
ATOM   2162 O OH  . TYR A 1 307 ? 179.06900 343.30800 30.20300  1.000 17.95148  ? 342 TYR F OH  1 
ATOM   2163 N N   . CYS A 1 308 ? 175.86100 335.39400 30.53100  1.000 15.27931  ? 343 CYS F N   1 
ATOM   2164 C CA  . CYS A 1 308 ? 175.32200 334.13900 31.03500  1.000 15.30170  ? 343 CYS F CA  1 
ATOM   2165 C C   . CYS A 1 308 ? 176.36600 333.48300 31.91800  1.000 16.00100  ? 343 CYS F C   1 
ATOM   2166 O O   . CYS A 1 308 ? 177.52100 333.35900 31.51700  1.000 14.67369  ? 343 CYS F O   1 
ATOM   2167 C CB  . CYS A 1 308 ? 174.92600 333.15100 29.93300  1.000 17.02424  ? 343 CYS F CB  1 
ATOM   2168 S SG  . CYS A 1 308 ? 173.60000 333.69900 28.80700  1.000 25.20849  ? 343 CYS F SG  1 
ATOM   2169 N N   . ASP A 1 309 ? 175.91600 332.92500 33.04700  1.000 18.23980  ? 344 ASP F N   1 
ATOM   2170 C CA  . ASP A 1 309 ? 176.79800 332.13800 33.90000  1.000 16.79229  ? 344 ASP F CA  1 
ATOM   2171 C C   . ASP A 1 309 ? 177.21800 330.89400 33.15000  1.000 16.40622  ? 344 ASP F C   1 
ATOM   2172 O O   . ASP A 1 309 ? 176.39300 330.25000 32.49300  1.000 16.91094  ? 344 ASP F O   1 
ATOM   2173 C CB  . ASP A 1 309 ? 176.11800 331.73200 35.20900  1.000 18.88653  ? 344 ASP F CB  1 
ATOM   2174 C CG  . ASP A 1 309 ? 175.95900 332.89400 36.15800  1.000 20.83041  ? 344 ASP F CG  1 
ATOM   2175 O OD1 . ASP A 1 309 ? 176.86100 333.75300 36.18600  1.000 23.21111  ? 344 ASP F OD1 1 
ATOM   2176 O OD2 . ASP A 1 309 ? 174.97400 332.91800 36.92000  1.000 32.25356  ? 344 ASP F OD2 1 
ATOM   2177 N N   . ASN A 1 310 ? 178.51800 330.61800 33.16000  1.000 15.29984  ? 345 ASN F N   1 
ATOM   2178 C CA  . ASN A 1 310 ? 179.07600 329.50900 32.40200  1.000 15.09183  ? 345 ASN F CA  1 
ATOM   2179 C C   . ASN A 1 310 ? 180.35100 328.96600 33.02900  1.000 14.68192  ? 345 ASN F C   1 
ATOM   2180 O O   . ASN A 1 310 ? 181.40400 329.61600 32.97300  1.000 12.02696  ? 345 ASN F O   1 
ATOM   2181 C CB  . ASN A 1 310 ? 179.30900 329.93600 30.95600  1.000 12.36156  ? 345 ASN F CB  1 
ATOM   2182 C CG  . ASN A 1 310 ? 179.74900 328.77300 30.08400  1.000 17.53346  ? 345 ASN F CG  1 
ATOM   2183 O OD1 . ASN A 1 310 ? 179.75400 327.62700 30.53800  1.000 13.97922  ? 345 ASN F OD1 1 
ATOM   2184 N ND2 . ASN A 1 310 ? 180.02900 329.04200 28.80100  1.000 13.13633  ? 345 ASN F ND2 1 
ATOM   2185 N N   . ALA A 1 311 ? 180.24100 327.79600 33.67200  1.000 15.45416  ? 346 ALA F N   1 
ATOM   2186 C CA  . ALA A 1 311 ? 181.41900 327.03500 34.12100  1.000 13.33297  ? 346 ALA F CA  1 
ATOM   2187 C C   . ALA A 1 311 ? 182.34200 327.84400 35.02700  1.000 14.03248  ? 346 ALA F C   1 
ATOM   2188 O O   . ALA A 1 311 ? 183.56500 327.78000 34.90300  1.000 15.33426  ? 346 ALA F O   1 
ATOM   2189 C CB  . ALA A 1 311 ? 182.19600 326.51900 32.90900  1.000 10.67235  ? 346 ALA F CB  1 
ATOM   2190 N N   . GLY A 1 312 ? 181.76700 328.45000 36.05600  1.000 13.08290  ? 347 GLY F N   1 
ATOM   2191 C CA  . GLY A 1 312 ? 182.51300 329.22100 37.02400  1.000 15.17589  ? 347 GLY F CA  1 
ATOM   2192 C C   . GLY A 1 312 ? 182.91400 330.60700 36.58700  1.000 17.41378  ? 347 GLY F C   1 
ATOM   2193 O O   . GLY A 1 312 ? 183.38300 331.38300 37.42500  1.000 18.13715  ? 347 GLY F O   1 
ATOM   2194 N N   . SER A 1 313 ? 182.68200 330.96200 35.33200  1.000 16.41559  ? 348 SER F N   1 
ATOM   2195 C CA  . SER A 1 313 ? 182.93200 332.27100 34.75000  1.000 19.45726  ? 348 SER F CA  1 
ATOM   2196 C C   . SER A 1 313 ? 181.62100 332.81000 34.14400  1.000 18.26898  ? 348 SER F C   1 
ATOM   2197 O O   . SER A 1 313 ? 180.54700 332.24600 34.35700  1.000 15.26607  ? 348 SER F O   1 
ATOM   2198 C CB  . SER A 1 313 ? 184.04200 332.19100 33.69400  1.000 12.03513  ? 348 SER F CB  1 
ATOM   2199 O OG  . SER A 1 313 ? 185.27800 331.87500 34.26600  1.000 22.56299  ? 348 SER F OG  1 
ATOM   2200 N N   . VAL A 1 314 ? 181.71100 333.96000 33.46100  1.000 15.52538  ? 349 VAL F N   1 
ATOM   2201 C CA  . VAL A 1 314 ? 180.59600 334.58900 32.74500  1.000 15.52499  ? 349 VAL F CA  1 
ATOM   2202 C C   . VAL A 1 314 ? 180.90800 334.64900 31.24700  1.000 15.65946  ? 349 VAL F C   1 
ATOM   2203 O O   . VAL A 1 314 ? 181.96400 335.14700 30.85700  1.000 16.26433  ? 349 VAL F O   1 
ATOM   2204 C CB  . VAL A 1 314 ? 180.29100 335.99200 33.31000  1.000 15.88675  ? 349 VAL F CB  1 
ATOM   2205 C CG1 . VAL A 1 314 ? 179.23000 336.68100 32.48600  1.000 16.72172  ? 349 VAL F CG1 1 
ATOM   2206 C CG2 . VAL A 1 314 ? 179.81400 335.88400 34.74900  1.000 15.60242  ? 349 VAL F CG2 1 
ATOM   2207 N N   . SER A 1 315 ? 180.00200 334.16100 30.40800  1.000 11.72349  ? 350 SER F N   1 
ATOM   2208 C CA  . SER A 1 315 ? 180.14300 334.28300 28.96300  1.000 15.38307  ? 350 SER F CA  1 
ATOM   2209 C C   . SER A 1 315 ? 179.41300 335.56500 28.55000  1.000 13.95049  ? 350 SER F C   1 
ATOM   2210 O O   . SER A 1 315 ? 178.23500 335.74000 28.87500  1.000 13.95390  ? 350 SER F O   1 
ATOM   2211 C CB  . SER A 1 315 ? 179.53500 333.09100 28.22300  1.000 10.67754  ? 350 SER F CB  1 
ATOM   2212 O OG  . SER A 1 315 ? 180.33000 331.93300 28.33800  1.000 15.56779  ? 350 SER F OG  1 
ATOM   2213 N N   . PHE A 1 316 ? 180.16300 336.52700 28.02700  1.000 16.86898  ? 351 PHE F N   1 
ATOM   2214 C CA  . PHE A 1 316 ? 179.64100 337.80300 27.55200  1.000 14.07012  ? 351 PHE F CA  1 
ATOM   2215 C C   . PHE A 1 316 ? 179.52300 337.84700 26.03300  1.000 14.88671  ? 351 PHE F C   1 
ATOM   2216 O O   . PHE A 1 316 ? 180.48600 337.55200 25.33200  1.000 11.43270  ? 351 PHE F O   1 
ATOM   2217 C CB  . PHE A 1 316 ? 180.56500 338.91100 28.08100  1.000 12.78275  ? 351 PHE F CB  1 
ATOM   2218 C CG  . PHE A 1 316 ? 180.31000 340.27000 27.50700  1.000 15.68711  ? 351 PHE F CG  1 
ATOM   2219 C CD1 . PHE A 1 316 ? 179.07400 340.88400 27.62100  1.000 14.54370  ? 351 PHE F CD1 1 
ATOM   2220 C CD2 . PHE A 1 316 ? 181.36700 340.99600 26.96000  1.000 17.01346  ? 351 PHE F CD2 1 
ATOM   2221 C CE1 . PHE A 1 316 ? 178.85900 342.14500 27.07900  1.000 15.36010  ? 351 PHE F CE1 1 
ATOM   2222 C CE2 . PHE A 1 316 ? 181.16700 342.28600 26.45100  1.000 15.27193  ? 351 PHE F CE2 1 
ATOM   2223 C CZ  . PHE A 1 316 ? 179.90200 342.84100 26.50500  1.000 15.98404  ? 351 PHE F CZ  1 
ATOM   2224 N N   . PHE A 1 317 ? 178.38400 338.32900 25.53900  1.000 13.96076  ? 352 PHE F N   1 
ATOM   2225 C CA  . PHE A 1 317 ? 178.08500 338.44200 24.10800  1.000 16.35421  ? 352 PHE F CA  1 
ATOM   2226 C C   . PHE A 1 317 ? 177.90100 339.90900 23.77300  1.000 18.45745  ? 352 PHE F C   1 
ATOM   2227 O O   . PHE A 1 317 ? 176.83600 340.49600 24.07000  1.000 19.72673  ? 352 PHE F O   1 
ATOM   2228 C CB  . PHE A 1 317 ? 176.84600 337.61900 23.74500  1.000 13.59088  ? 352 PHE F CB  1 
ATOM   2229 C CG  . PHE A 1 317 ? 176.97200 336.19600 24.16900  1.000 17.70720  ? 352 PHE F CG  1 
ATOM   2230 C CD1 . PHE A 1 317 ? 176.59000 335.77700 25.43700  1.000 16.67055  ? 352 PHE F CD1 1 
ATOM   2231 C CD2 . PHE A 1 317 ? 177.46200 335.25600 23.25900  1.000 14.78524  ? 352 PHE F CD2 1 
ATOM   2232 C CE1 . PHE A 1 317 ? 176.77000 334.45700 25.82300  1.000 18.85101  ? 352 PHE F CE1 1 
ATOM   2233 C CE2 . PHE A 1 317 ? 177.62400 333.92200 23.63600  1.000 16.56139  ? 352 PHE F CE2 1 
ATOM   2234 C CZ  . PHE A 1 317 ? 177.27900 333.52600 24.91600  1.000 13.45235  ? 352 PHE F CZ  1 
ATOM   2235 N N   . PRO A 1 318 ? 178.94800 340.53600 23.22700  1.000 17.15130  ? 353 PRO F N   1 
ATOM   2236 C CA  . PRO A 1 318 ? 178.91800 341.96300 22.89000  1.000 23.83818  ? 353 PRO F CA  1 
ATOM   2237 C C   . PRO A 1 318 ? 178.11400 342.27800 21.62800  1.000 26.37532  ? 353 PRO F C   1 
ATOM   2238 O O   . PRO A 1 318 ? 177.55900 343.37500 21.60500  1.000 30.43138  ? 353 PRO F O   1 
ATOM   2239 C CB  . PRO A 1 318 ? 180.40200 342.32700 22.74200  1.000 17.68680  ? 353 PRO F CB  1 
ATOM   2240 C CG  . PRO A 1 318 ? 181.06000 341.05700 22.36600  1.000 23.77963  ? 353 PRO F CG  1 
ATOM   2241 C CD  . PRO A 1 318 ? 180.29100 339.95500 23.07700  1.000 17.65650  ? 353 PRO F CD  1 
ATOM   2242 N N   . GLN A 1 319 ? 178.15200 341.47200 20.54400  1.000 28.80343  ? 354 GLN F N   1 
ATOM   2243 C CA  . GLN A 1 319 ? 177.34100 341.80200 19.35900  1.000 32.41545  ? 354 GLN F CA  1 
ATOM   2244 C C   . GLN A 1 319 ? 175.88500 341.53900 19.71200  1.000 37.90811  ? 354 GLN F C   1 
ATOM   2245 O O   . GLN A 1 319 ? 175.55300 340.42900 20.14300  1.000 30.26072  ? 354 GLN F O   1 
ATOM   2246 C CB  . GLN A 1 319 ? 177.66400 340.92900 18.15000  1.000 38.42572  ? 354 GLN F CB  1 
ATOM   2247 C CG  . GLN A 1 319 ? 178.84800 341.23900 17.29600  1.000 48.99988  ? 354 GLN F CG  1 
ATOM   2248 C CD  . GLN A 1 319 ? 180.14700 340.95100 18.01400  1.000 62.88759  ? 354 GLN F CD  1 
ATOM   2249 O OE1 . GLN A 1 319 ? 180.82500 341.85600 18.50500  1.000 64.36998  ? 354 GLN F OE1 1 
ATOM   2250 N NE2 . GLN A 1 319 ? 180.51100 339.65500 18.07400  1.000 65.00744  ? 354 GLN F NE2 1 
ATOM   2251 N N   . ALA A 1 320 ? 174.97100 342.40100 19.24800  1.000 51.04044  ? 355 ALA F N   1 
ATOM   2252 C CA  . ALA A 1 320 ? 173.61200 342.24600 19.78200  1.000 55.38575  ? 355 ALA F CA  1 
ATOM   2253 C C   . ALA A 1 320 ? 172.77000 341.12400 19.17300  1.000 48.66791  ? 355 ALA F C   1 
ATOM   2254 O O   . ALA A 1 320 ? 172.04100 340.44000 19.90400  1.000 60.22889  ? 355 ALA F O   1 
ATOM   2255 C CB  . ALA A 1 320 ? 172.86100 343.57200 19.61300  1.000 59.26341  ? 355 ALA F CB  1 
ATOM   2256 N N   . GLU A 1 321 ? 172.95600 340.82200 17.91400  1.000 41.58166  ? 356 GLU F N   1 
ATOM   2257 C CA  . GLU A 1 321 ? 172.16800 339.83700 17.18600  1.000 51.64845  ? 356 GLU F CA  1 
ATOM   2258 C C   . GLU A 1 321 ? 172.69900 338.40500 17.26200  1.000 43.64507  ? 356 GLU F C   1 
ATOM   2259 O O   . GLU A 1 321 ? 172.10200 337.51200 16.65600  1.000 54.69730  ? 356 GLU F O   1 
ATOM   2260 C CB  . GLU A 1 321 ? 171.99400 340.32600 15.74400  1.000 58.49679  ? 356 GLU F CB  1 
ATOM   2261 C CG  . GLU A 1 321 ? 173.27000 340.29300 14.96400  1.000 65.27924  ? 356 GLU F CG  1 
ATOM   2262 C CD  . GLU A 1 321 ? 174.15400 341.47900 15.34700  1.000 74.88904  ? 356 GLU F CD  1 
ATOM   2263 O OE1 . GLU A 1 321 ? 174.86900 341.37600 16.38100  1.000 58.04622  ? 356 GLU F OE1 1 
ATOM   2264 O OE2 . GLU A 1 321 ? 174.10400 342.51700 14.63600  1.000 80.96012  ? 356 GLU F OE2 1 
ATOM   2265 N N   . THR A 1 322 ? 173.77500 338.15600 17.99300  1.000 31.59835  ? 357 THR F N   1 
ATOM   2266 C CA  . THR A 1 322 ? 174.36800 336.82800 18.10900  1.000 33.76579  ? 357 THR F CA  1 
ATOM   2267 C C   . THR A 1 322 ? 173.68100 335.92400 19.12100  1.000 34.96955  ? 357 THR F C   1 
ATOM   2268 O O   . THR A 1 322 ? 173.96500 334.72800 19.11800  1.000 42.90969  ? 357 THR F O   1 
ATOM   2269 C CB  . THR A 1 322 ? 175.85200 336.92900 18.48200  1.000 29.70783  ? 357 THR F CB  1 
ATOM   2270 O OG1 . THR A 1 322 ? 176.00100 337.66400 19.70800  1.000 37.01742  ? 357 THR F OG1 1 
ATOM   2271 C CG2 . THR A 1 322 ? 176.62000 337.62900 17.35200  1.000 40.62298  ? 357 THR F CG2 1 
ATOM   2272 N N   . CYS A 1 323 ? 172.63000 336.38100 19.78200  1.000 27.23129  ? 358 CYS F N   1 
ATOM   2273 C CA  . CYS A 1 323 ? 171.89700 335.60500 20.77500  1.000 24.14348  ? 358 CYS F CA  1 
ATOM   2274 C C   . CYS A 1 323 ? 170.43200 335.73600 20.44300  1.000 27.43277  ? 358 CYS F C   1 
ATOM   2275 O O   . CYS A 1 323 ? 169.95100 336.84500 20.21100  1.000 28.30206  ? 358 CYS F O   1 
ATOM   2276 C CB  . CYS A 1 323 ? 172.11700 336.05800 22.22900  1.000 19.90180  ? 358 CYS F CB  1 
ATOM   2277 S SG  . CYS A 1 323 ? 173.72600 335.68600 22.97400  1.000 27.24971  ? 358 CYS F SG  1 
ATOM   2278 N N   . LYS A 1 324 ? 169.80800 334.59000 20.17200  1.000 25.22293  ? 359 LYS F N   1 
ATOM   2279 C CA  . LYS A 1 324 ? 168.38300 334.52300 19.90700  1.000 25.02947  ? 359 LYS F CA  1 
ATOM   2280 C C   . LYS A 1 324 ? 167.63800 334.17900 21.18500  1.000 26.48156  ? 359 LYS F C   1 
ATOM   2281 O O   . LYS A 1 324 ? 167.97000 333.23500 21.90000  1.000 25.65348  ? 359 LYS F O   1 
ATOM   2282 C CB  . LYS A 1 324 ? 168.05200 333.49500 18.81700  1.000 23.69124  ? 359 LYS F CB  1 
ATOM   2283 C CG  . LYS A 1 324 ? 169.04400 333.49700 17.68300  1.000 26.64404  ? 359 LYS F CG  1 
ATOM   2284 C CD  . LYS A 1 324 ? 169.09300 334.84900 17.01000  1.000 31.06513  ? 359 LYS F CD  1 
ATOM   2285 C CE  . LYS A 1 324 ? 169.73000 334.75000 15.63000  1.000 44.17445  ? 359 LYS F CE  1 
ATOM   2286 N NZ  . LYS A 1 324 ? 169.88600 336.10900 15.01500  1.000 61.27910  ? 359 LYS F NZ  1 
ATOM   2287 N N   . VAL A 1 325 ? 166.56400 334.89500 21.39700  1.000 26.24401  ? 360 VAL F N   1 
ATOM   2288 C CA  . VAL A 1 325 ? 165.74200 334.83000 22.58500  1.000 24.79018  ? 360 VAL F CA  1 
ATOM   2289 C C   . VAL A 1 325 ? 164.39800 334.26700 22.16500  1.000 34.39169  ? 360 VAL F C   1 
ATOM   2290 O O   . VAL A 1 325 ? 163.81300 334.71000 21.16900  1.000 36.53765  ? 360 VAL F O   1 
ATOM   2291 C CB  . VAL A 1 325 ? 165.59800 336.19000 23.27600  1.000 29.20433  ? 360 VAL F CB  1 
ATOM   2292 C CG1 . VAL A 1 325 ? 164.79500 336.02900 24.54800  1.000 26.33159  ? 360 VAL F CG1 1 
ATOM   2293 C CG2 . VAL A 1 325 ? 166.97800 336.78200 23.55100  1.000 26.30306  ? 360 VAL F CG2 1 
ATOM   2294 N N   . GLN A 1 326 ? 163.86400 333.37200 22.99600  1.000 31.92539  ? 361 GLN F N   1 
ATOM   2295 C CA  . GLN A 1 326 ? 162.53200 332.82700 22.79800  1.000 39.84029  ? 361 GLN F CA  1 
ATOM   2296 C C   . GLN A 1 326 ? 161.65800 333.07900 24.01800  1.000 50.65506  ? 361 GLN F C   1 
ATOM   2297 O O   . GLN A 1 326 ? 161.08200 334.17300 24.14100  1.000 60.79048  ? 361 GLN F O   1 
ATOM   2298 C CB  . GLN A 1 326 ? 162.64600 331.33000 22.50700  1.000 43.39357  ? 361 GLN F CB  1 
ATOM   2299 C CG  . GLN A 1 326 ? 161.53900 330.75700 21.66700  1.000 50.23174  ? 361 GLN F CG  1 
ATOM   2300 C CD  . GLN A 1 326 ? 160.47600 330.21200 22.62900  1.000 62.32978  ? 361 GLN F CD  1 
ATOM   2301 O OE1 . GLN A 1 326 ? 159.27200 330.41700 22.44300  1.000 61.13030  ? 361 GLN F OE1 1 
ATOM   2302 N NE2 . GLN A 1 326 ? 160.93700 329.52100 23.68300  1.000 64.51357  ? 361 GLN F NE2 1 
ATOM   2303 N N   . SER A 1 327 ? 161.42800 332.11200 24.87200  1.000 44.87089  ? 362 SER F N   1 
ATOM   2304 C CA  . SER A 1 327 ? 160.54100 332.43200 25.97800  1.000 49.24005  ? 362 SER F CA  1 
ATOM   2305 C C   . SER A 1 327 ? 161.46700 332.31600 27.16700  1.000 45.84951  ? 362 SER F C   1 
ATOM   2306 O O   . SER A 1 327 ? 161.55700 331.27000 27.81500  1.000 50.07882  ? 362 SER F O   1 
ATOM   2307 C CB  . SER A 1 327 ? 159.31900 331.53900 26.03100  1.000 52.80015  ? 362 SER F CB  1 
ATOM   2308 O OG  . SER A 1 327 ? 159.60100 330.26600 25.48500  1.000 58.90710  ? 362 SER F OG  1 
ATOM   2309 N N   . ASN A 1 328 ? 162.20300 333.39300 27.40600  1.000 31.31401  ? 363 ASN F N   1 
ATOM   2310 C CA  . ASN A 1 328 ? 163.05500 333.51300 28.56700  1.000 31.14329  ? 363 ASN F CA  1 
ATOM   2311 C C   . ASN A 1 328 ? 164.28700 332.63300 28.44000  1.000 20.41415  ? 363 ASN F C   1 
ATOM   2312 O O   . ASN A 1 328 ? 165.08500 332.55500 29.36900  1.000 22.92390  ? 363 ASN F O   1 
ATOM   2313 C CB  . ASN A 1 328 ? 162.23700 333.23900 29.82400  1.000 28.47898  ? 363 ASN F CB  1 
ATOM   2314 C CG  . ASN A 1 328 ? 160.94400 334.05100 29.81600  1.000 48.44282  ? 363 ASN F CG  1 
ATOM   2315 O OD1 . ASN A 1 328 ? 159.93800 333.68400 30.43400  1.000 52.32234  ? 363 ASN F OD1 1 
ATOM   2316 N ND2 . ASN A 1 328 ? 160.96900 335.17500 29.07200  1.000 44.27569  ? 363 ASN F ND2 1 
ATOM   2317 N N   . ARG A 1 329 ? 164.48100 332.00000 27.29100  1.000 21.21134  ? 364 ARG F N   1 
ATOM   2318 C CA  . ARG A 1 329 ? 165.67900 331.22000 27.01500  1.000 27.66870  ? 364 ARG F CA  1 
ATOM   2319 C C   . ARG A 1 329 ? 166.50400 331.93200 25.95000  1.000 22.89979  ? 364 ARG F C   1 
ATOM   2320 O O   . ARG A 1 329 ? 165.94300 332.43800 24.96500  1.000 23.40481  ? 364 ARG F O   1 
ATOM   2321 C CB  . ARG A 1 329 ? 165.32300 329.80500 26.55800  1.000 26.30483  ? 364 ARG F CB  1 
ATOM   2322 C CG  . ARG A 1 329 ? 166.56800 328.90400 26.40200  1.000 23.16570  ? 364 ARG F CG  1 
ATOM   2323 C CD  . ARG A 1 329 ? 166.19300 327.43600 26.30900  1.000 28.73767  ? 364 ARG F CD  1 
ATOM   2324 N NE  . ARG A 1 329 ? 165.37300 326.97400 27.42700  1.000 28.51973  ? 364 ARG F NE  1 
ATOM   2325 C CZ  . ARG A 1 329 ? 165.87400 326.57600 28.58800  1.000 29.97236  ? 364 ARG F CZ  1 
ATOM   2326 N NH1 . ARG A 1 329 ? 167.17700 326.61200 28.82100  1.000 24.95170  ? 364 ARG F NH1 1 
ATOM   2327 N NH2 . ARG A 1 329 ? 165.04900 326.14500 29.54200  1.000 23.64631  ? 364 ARG F NH2 1 
ATOM   2328 N N   . VAL A 1 330 ? 167.81800 332.03800 26.18700  1.000 17.16628  ? 365 VAL F N   1 
ATOM   2329 C CA  . VAL A 1 330 ? 168.76000 332.66600 25.25400  1.000 16.77420  ? 365 VAL F CA  1 
ATOM   2330 C C   . VAL A 1 330 ? 169.59600 331.56200 24.63300  1.000 15.99116  ? 365 VAL F C   1 
ATOM   2331 O O   . VAL A 1 330 ? 170.32800 330.87900 25.35900  1.000 18.94087  ? 365 VAL F O   1 
ATOM   2332 C CB  . VAL A 1 330 ? 169.63300 333.67800 26.03600  1.000 20.80705  ? 365 VAL F CB  1 
ATOM   2333 C CG1 . VAL A 1 330 ? 170.36700 334.67800 25.13200  1.000 18.21075  ? 365 VAL F CG1 1 
ATOM   2334 C CG2 . VAL A 1 330 ? 168.75200 334.45100 27.00800  1.000 17.87001  ? 365 VAL F CG2 1 
ATOM   2335 N N   . PHE A 1 331 ? 169.77100 331.63300 23.32400  1.000 17.21312  ? 366 PHE F N   1 
ATOM   2336 C CA  . PHE A 1 331 ? 170.51900 330.64700 22.54100  1.000 15.72752  ? 366 PHE F CA  1 
ATOM   2337 C C   . PHE A 1 331 ? 171.65600 331.38900 21.88100  1.000 23.52473  ? 366 PHE F C   1 
ATOM   2338 O O   . PHE A 1 331 ? 171.42300 332.28300 21.05400  1.000 21.50018  ? 366 PHE F O   1 
ATOM   2339 C CB  . PHE A 1 331 ? 169.65700 330.02900 21.44300  1.000 18.57975  ? 366 PHE F CB  1 
ATOM   2340 C CG  . PHE A 1 331 ? 168.55000 329.13800 21.92000  1.000 17.97767  ? 366 PHE F CG  1 
ATOM   2341 C CD1 . PHE A 1 331 ? 167.35700 329.67400 22.34800  1.000 19.14955  ? 366 PHE F CD1 1 
ATOM   2342 C CD2 . PHE A 1 331 ? 168.66200 327.76100 21.82000  1.000 20.77870  ? 366 PHE F CD2 1 
ATOM   2343 C CE1 . PHE A 1 331 ? 166.31800 328.85600 22.74800  1.000 23.32294  ? 366 PHE F CE1 1 
ATOM   2344 C CE2 . PHE A 1 331 ? 167.60400 326.92200 22.20500  1.000 17.29471  ? 366 PHE F CE2 1 
ATOM   2345 C CZ  . PHE A 1 331 ? 166.44200 327.46700 22.65900  1.000 18.16492  ? 366 PHE F CZ  1 
ATOM   2346 N N   . CYS A 1 332 ? 172.84100 331.17900 22.43400  1.000 17.96657  ? 367 CYS F N   1 
ATOM   2347 C CA  . CYS A 1 332 ? 174.06600 331.81600 21.99400  1.000 18.42588  ? 367 CYS F CA  1 
ATOM   2348 C C   . CYS A 1 332 ? 175.03800 330.74900 21.49100  1.000 20.10139  ? 367 CYS F C   1 
ATOM   2349 O O   . CYS A 1 332 ? 175.01800 329.60000 21.94700  1.000 20.48535  ? 367 CYS F O   1 
ATOM   2350 C CB  . CYS A 1 332 ? 174.66100 332.58800 23.16500  1.000 18.65737  ? 367 CYS F CB  1 
ATOM   2351 S SG  . CYS A 1 332 ? 173.43700 333.74500 23.74800  1.000 24.17609  ? 367 CYS F SG  1 
ATOM   2352 N N   . ASP A 1 333 ? 176.02700 331.18900 20.74600  1.000 17.95597  ? 368 ASP F N   1 
ATOM   2353 C CA  . ASP A 1 333 ? 177.13200 330.36600 20.26100  1.000 19.06807  ? 368 ASP F CA  1 
ATOM   2354 C C   . ASP A 1 333 ? 178.32400 330.92600 21.01900  1.000 17.43212  ? 368 ASP F C   1 
ATOM   2355 O O   . ASP A 1 333 ? 178.61400 332.12100 20.92100  1.000 15.09054  ? 368 ASP F O   1 
ATOM   2356 C CB  . ASP A 1 333 ? 177.33600 330.39800 18.73600  1.000 16.49119  ? 368 ASP F CB  1 
ATOM   2357 C CG  . ASP A 1 333 ? 178.32100 329.30200 18.25800  1.000 23.62474  ? 368 ASP F CG  1 
ATOM   2358 O OD1 . ASP A 1 333 ? 179.34800 329.11800 18.98100  1.000 21.41367  ? 368 ASP F OD1 1 
ATOM   2359 O OD2 . ASP A 1 333 ? 178.11300 328.60100 17.24400  1.000 23.56716  ? 368 ASP F OD2 1 
ATOM   2360 N N   . THR A 1 334 ? 179.02700 330.04300 21.75900  1.000 17.21955  ? 369 THR F N   1 
ATOM   2361 C CA  . THR A 1 334 ? 180.13300 330.54800 22.57300  1.000 16.37376  ? 369 THR F CA  1 
ATOM   2362 C C   . THR A 1 334 ? 181.29200 331.02200 21.72900  1.000 20.13641  ? 369 THR F C   1 
ATOM   2363 O O   . THR A 1 334 ? 182.16600 331.73100 22.24200  1.000 20.59001  ? 369 THR F O   1 
ATOM   2364 C CB  . THR A 1 334 ? 180.56100 329.44000 23.55600  1.000 19.86438  ? 369 THR F CB  1 
ATOM   2365 O OG1 . THR A 1 334 ? 181.01300 328.28800 22.82400  1.000 17.95954  ? 369 THR F OG1 1 
ATOM   2366 C CG2 . THR A 1 334 ? 179.46000 329.04900 24.59300  1.000 16.08819  ? 369 THR F CG2 1 
ATOM   2367 N N   . MET A 1 335 ? 181.29100 330.80700 20.43500  1.000 17.39787  ? 370 MET F N   1 
ATOM   2368 C CA  . MET A 1 335 ? 182.32200 331.38200 19.57900  1.000 20.91655  ? 370 MET F CA  1 
ATOM   2369 C C   . MET A 1 335 ? 182.17500 332.90000 19.43000  1.000 20.72980  ? 370 MET F C   1 
ATOM   2370 O O   . MET A 1 335 ? 183.11700 333.55300 19.08600  1.000 24.49369  ? 370 MET F O   1 
ATOM   2371 C CB  . MET A 1 335 ? 182.39000 330.68500 18.22900  1.000 20.11846  ? 370 MET F CB  1 
ATOM   2372 C CG  . MET A 1 335 ? 183.07900 329.33600 18.29500  1.000 27.11965  ? 370 MET F CG  1 
ATOM   2373 S SD  . MET A 1 335 ? 183.36200 328.56900 16.69700  1.000 40.71561  ? 370 MET F SD  1 
ATOM   2374 C CE  . MET A 1 335 ? 184.48900 329.73500 15.96500  1.000 26.18465  ? 370 MET F CE  1 
ATOM   2375 N N   . ASN A 1 336 ? 181.02600 333.44500 19.76600  1.000 20.60750  ? 371 ASN F N   1 
ATOM   2376 C CA  . ASN A 1 336 ? 180.80300 334.88200 19.74000  1.000 25.68223  ? 371 ASN F CA  1 
ATOM   2377 C C   . ASN A 1 336 ? 180.85800 335.50100 21.14900  1.000 22.59622  ? 371 ASN F C   1 
ATOM   2378 O O   . ASN A 1 336 ? 180.23100 336.50500 21.41600  1.000 21.23505  ? 371 ASN F O   1 
ATOM   2379 C CB  . ASN A 1 336 ? 179.46400 335.18500 19.08100  1.000 22.51631  ? 371 ASN F CB  1 
ATOM   2380 C CG  . ASN A 1 336 ? 179.29200 334.49300 17.75500  1.000 30.28019  ? 371 ASN F CG  1 
ATOM   2381 O OD1 . ASN A 1 336 ? 178.26700 333.88000 17.49900  1.000 28.47443  ? 371 ASN F OD1 1 
ATOM   2382 N ND2 . ASN A 1 336 ? 180.29200 334.59300 16.90300  1.000 26.24231  ? 371 ASN F ND2 1 
ATOM   2383 N N   . SER A 1 337 ? 181.60900 334.88500 22.03900  1.000 17.10716  ? 372 SER F N   1 
ATOM   2384 C CA  . SER A 1 337 ? 181.72900 335.38500 23.40200  1.000 18.19711  ? 372 SER F CA  1 
ATOM   2385 C C   . SER A 1 337 ? 183.07300 335.71800 23.95800  1.000 16.83289  ? 372 SER F C   1 
ATOM   2386 O O   . SER A 1 337 ? 184.08000 335.30800 23.43000  1.000 19.70131  ? 372 SER F O   1 
ATOM   2387 C CB  . SER A 1 337 ? 181.16700 334.34300 24.38700  1.000 14.29271  ? 372 SER F CB  1 
ATOM   2388 O OG  . SER A 1 337 ? 182.05100 333.28000 24.61400  1.000 17.15768  ? 372 SER F OG  1 
ATOM   2389 N N   . LEU A 1 338 ? 183.08000 336.49400 25.01900  1.000 15.39991  ? 373 LEU F N   1 
ATOM   2390 C CA  . LEU A 1 338 ? 184.29500 336.66600 25.77900  1.000 16.26815  ? 373 LEU F CA  1 
ATOM   2391 C C   . LEU A 1 338 ? 184.04700 336.03600 27.14400  1.000 19.17362  ? 373 LEU F C   1 
ATOM   2392 O O   . LEU A 1 338 ? 182.90500 335.96800 27.61200  1.000 15.46298  ? 373 LEU F O   1 
ATOM   2393 C CB  . LEU A 1 338 ? 184.64500 338.16200 25.90000  1.000 16.21050  ? 373 LEU F CB  1 
ATOM   2394 C CG  . LEU A 1 338 ? 184.78500 338.92500 24.56000  1.000 21.92789  ? 373 LEU F CG  1 
ATOM   2395 C CD1 . LEU A 1 338 ? 184.91300 340.47100 24.72000  1.000 17.64900  ? 373 LEU F CD1 1 
ATOM   2396 C CD2 . LEU A 1 338 ? 185.97000 338.40100 23.77200  1.000 19.19962  ? 373 LEU F CD2 1 
ATOM   2397 N N   . THR A 1 339 ? 185.10300 335.53500 27.76200  1.000 12.71010  ? 374 THR F N   1 
ATOM   2398 C CA  . THR A 1 339 ? 184.99800 334.88300 29.06100  1.000 17.84153  ? 374 THR F CA  1 
ATOM   2399 C C   . THR A 1 339 ? 185.46900 335.87200 30.11500  1.000 14.39875  ? 374 THR F C   1 
ATOM   2400 O O   . THR A 1 339 ? 186.62200 336.28900 30.09300  1.000 12.65496  ? 374 THR F O   1 
ATOM   2401 C CB  . THR A 1 339 ? 185.79500 333.58200 29.09600  1.000 15.46659  ? 374 THR F CB  1 
ATOM   2402 O OG1 . THR A 1 339 ? 185.31900 332.75900 28.03000  1.000 14.08467  ? 374 THR F OG1 1 
ATOM   2403 C CG2 . THR A 1 339 ? 185.53300 332.83500 30.42200  1.000 10.06223  ? 374 THR F CG2 1 
ATOM   2404 N N   . LEU A 1 340 ? 184.58200 336.22900 31.03600  1.000 11.69485  ? 375 LEU F N   1 
ATOM   2405 C CA  . LEU A 1 340 ? 184.88800 337.20200 32.06100  1.000 15.37096  ? 375 LEU F CA  1 
ATOM   2406 C C   . LEU A 1 340 ? 184.74300 336.60700 33.45200  1.000 12.39859  ? 375 LEU F C   1 
ATOM   2407 O O   . LEU A 1 340 ? 184.00700 335.64100 33.64700  1.000 13.56175  ? 375 LEU F O   1 
ATOM   2408 C CB  . LEU A 1 340 ? 183.91900 338.39400 31.95100  1.000 15.67955  ? 375 LEU F CB  1 
ATOM   2409 C CG  . LEU A 1 340 ? 183.82800 339.09300 30.57900  1.000 18.91802  ? 375 LEU F CG  1 
ATOM   2410 C CD1 . LEU A 1 340 ? 182.79500 340.20900 30.63700  1.000 15.40375  ? 375 LEU F CD1 1 
ATOM   2411 C CD2 . LEU A 1 340 ? 185.14500 339.61400 30.11900  1.000 17.51727  ? 375 LEU F CD2 1 
ATOM   2412 N N   . PRO A 1 341 ? 185.46900 337.12700 34.43000  1.000 13.82807  ? 376 PRO F N   1 
ATOM   2413 C CA  . PRO A 1 341 ? 185.24800 336.67100 35.80500  1.000 16.82314  ? 376 PRO F CA  1 
ATOM   2414 C C   . PRO A 1 341 ? 183.84100 337.03600 36.26500  1.000 22.13587  ? 376 PRO F C   1 
ATOM   2415 O O   . PRO A 1 341 ? 183.24300 338.01700 35.80000  1.000 17.39355  ? 376 PRO F O   1 
ATOM   2416 C CB  . PRO A 1 341 ? 186.31200 337.42600 36.61400  1.000 14.76176  ? 376 PRO F CB  1 
ATOM   2417 C CG  . PRO A 1 341 ? 186.65100 338.65400 35.74400  1.000 20.31996  ? 376 PRO F CG  1 
ATOM   2418 C CD  . PRO A 1 341 ? 186.52500 338.15400 34.32600  1.000 13.70491  ? 376 PRO F CD  1 
ATOM   2419 N N   . SER A 1 342 ? 183.29400 336.21400 37.17300  1.000 13.94919  ? 377 SER F N   1 
ATOM   2420 C CA  . SER A 1 342 ? 181.94200 336.47800 37.66700  1.000 18.52490  ? 377 SER F CA  1 
ATOM   2421 C C   . SER A 1 342 ? 181.85600 337.80700 38.42400  1.000 18.09606  ? 377 SER F C   1 
ATOM   2422 O O   . SER A 1 342 ? 180.76600 338.39200 38.50000  1.000 18.84745  ? 377 SER F O   1 
ATOM   2423 C CB  . SER A 1 342 ? 181.44400 335.32700 38.55300  1.000 18.20585  ? 377 SER F CB  1 
ATOM   2424 O OG  . SER A 1 342 ? 182.28900 335.15700 39.66900  1.000 25.18602  ? 377 SER F OG  1 
ATOM   2425 N N   . GLU A 1 343 ? 182.99400 338.39900 38.78800  1.000 16.87341  ? 378 GLU F N   1 
ATOM   2426 C CA  . GLU A 1 343 ? 182.94600 339.68100 39.46500  1.000 18.55269  ? 378 GLU F CA  1 
ATOM   2427 C C   . GLU A 1 343 ? 182.49400 340.78200 38.52600  1.000 20.57815  ? 378 GLU F C   1 
ATOM   2428 O O   . GLU A 1 343 ? 182.21000 341.88600 38.99500  1.000 17.75802  ? 378 GLU F O   1 
ATOM   2429 C CB  . GLU A 1 343 ? 184.31200 340.07000 40.05300  1.000 18.90905  ? 378 GLU F CB  1 
ATOM   2430 C CG  . GLU A 1 343 ? 184.76400 339.28400 41.30500  1.000 23.41493  ? 378 GLU F CG  1 
ATOM   2431 C CD  . GLU A 1 343 ? 185.06000 337.81400 41.04700  1.000 26.37980  ? 378 GLU F CD  1 
ATOM   2432 O OE1 . GLU A 1 343 ? 185.45000 337.44200 39.91000  1.000 22.69185  ? 378 GLU F OE1 1 
ATOM   2433 O OE2 . GLU A 1 343 ? 184.91100 337.03100 42.00100  1.000 28.21512  ? 378 GLU F OE2 1 
ATOM   2434 N N   . VAL A 1 344 ? 182.33600 340.49300 37.22900  1.000 16.17521  ? 379 VAL F N   1 
ATOM   2435 C CA  . VAL A 1 344 ? 181.88200 341.53500 36.32800  1.000 16.10639  ? 379 VAL F CA  1 
ATOM   2436 C C   . VAL A 1 344 ? 180.45700 341.92700 36.71100  1.000 19.42591  ? 379 VAL F C   1 
ATOM   2437 O O   . VAL A 1 344 ? 180.09500 343.09700 36.61300  1.000 18.89802  ? 379 VAL F O   1 
ATOM   2438 C CB  . VAL A 1 344 ? 181.94800 341.03300 34.86800  1.000 18.44839  ? 379 VAL F CB  1 
ATOM   2439 C CG1 . VAL A 1 344 ? 180.84000 340.00700 34.60200  1.000 14.36239  ? 379 VAL F CG1 1 
ATOM   2440 C CG2 . VAL A 1 344 ? 181.80300 342.18500 33.89700  1.000 19.15236  ? 379 VAL F CG2 1 
ATOM   2441 N N   . ASN A 1 345 ? 179.73200 341.04500 37.39300  1.000 20.79962  ? 380 ASN F N   1 
ATOM   2442 C CA  . ASN A 1 345 ? 178.37800 341.41100 37.80300  1.000 23.35706  ? 380 ASN F CA  1 
ATOM   2443 C C   . ASN A 1 345 ? 178.36600 342.45700 38.90100  1.000 28.81009  ? 380 ASN F C   1 
ATOM   2444 O O   . ASN A 1 345 ? 177.34000 343.12500 39.11300  1.000 27.27708  ? 380 ASN F O   1 
ATOM   2445 C CB  . ASN A 1 345 ? 177.58200 340.20700 38.29500  1.000 18.97798  ? 380 ASN F CB  1 
ATOM   2446 C CG  . ASN A 1 345 ? 176.10400 340.57200 38.58600  1.000 36.96938  ? 380 ASN F CG  1 
ATOM   2447 O OD1 . ASN A 1 345 ? 175.37000 341.06100 37.70200  1.000 23.97723  ? 380 ASN F OD1 1 
ATOM   2448 N ND2 . ASN A 1 345 ? 175.65700 340.29400 39.81200  1.000 32.12014  ? 380 ASN F ND2 1 
ATOM   2449 N N   . LEU A 1 346 ? 179.49300 342.68000 39.54500  1.000 21.42576  ? 381 LEU F N   1 
ATOM   2450 C CA  . LEU A 1 346 ? 179.46200 343.64800 40.60900  1.000 21.67299  ? 381 LEU F CA  1 
ATOM   2451 C C   . LEU A 1 346 ? 179.46200 345.07700 40.05000  1.000 25.06370  ? 381 LEU F C   1 
ATOM   2452 O O   . LEU A 1 346 ? 179.15000 346.02200 40.78900  1.000 21.12965  ? 381 LEU F O   1 
ATOM   2453 C CB  . LEU A 1 346 ? 180.74000 343.38200 41.41500  1.000 24.88787  ? 381 LEU F CB  1 
ATOM   2454 C CG  . LEU A 1 346 ? 180.77700 342.29700 42.51800  1.000 30.11491  ? 381 LEU F CG  1 
ATOM   2455 C CD1 . LEU A 1 346 ? 182.17000 342.24700 43.18000  1.000 28.01159  ? 381 LEU F CD1 1 
ATOM   2456 C CD2 . LEU A 1 346 ? 179.62100 342.23700 43.54500  1.000 27.56552  ? 381 LEU F CD2 1 
ATOM   2457 N N   . CYS A 1 347 ? 179.59000 345.25100 38.72200  1.000 25.09218  ? 382 CYS F N   1 
ATOM   2458 C CA  . CYS A 1 347 ? 179.44200 346.60900 38.20600  1.000 20.95187  ? 382 CYS F CA  1 
ATOM   2459 C C   . CYS A 1 347 ? 177.98900 347.03300 38.30600  1.000 24.41900  ? 382 CYS F C   1 
ATOM   2460 O O   . CYS A 1 347 ? 177.66700 348.21500 38.17900  1.000 21.37062  ? 382 CYS F O   1 
ATOM   2461 C CB  . CYS A 1 347 ? 179.93000 346.66600 36.77100  1.000 20.80261  ? 382 CYS F CB  1 
ATOM   2462 S SG  . CYS A 1 347 ? 181.72500 346.38800 36.70500  1.000 29.02519  ? 382 CYS F SG  1 
ATOM   2463 N N   . ASN A 1 348 ? 177.10400 346.05200 38.39600  1.000 19.98159  ? 383 ASN F N   1 
ATOM   2464 C CA  . ASN A 1 348 ? 175.69200 346.26500 38.57900  1.000 20.55287  ? 383 ASN F CA  1 
ATOM   2465 C C   . ASN A 1 348 ? 175.35200 346.52800 40.04100  1.000 26.40454  ? 383 ASN F C   1 
ATOM   2466 O O   . ASN A 1 348 ? 174.23100 346.94300 40.33700  1.000 30.55760  ? 383 ASN F O   1 
ATOM   2467 C CB  . ASN A 1 348 ? 174.86700 345.16800 37.92900  1.000 19.29539  ? 383 ASN F CB  1 
ATOM   2468 C CG  . ASN A 1 348 ? 175.32800 344.93800 36.52300  1.000 22.94941  ? 383 ASN F CG  1 
ATOM   2469 O OD1 . ASN A 1 348 ? 175.19100 345.82500 35.66400  1.000 15.62224  ? 383 ASN F OD1 1 
ATOM   2470 N ND2 . ASN A 1 348 ? 175.61700 343.68800 36.21400  1.000 16.77526  ? 383 ASN F ND2 1 
ATOM   2471 N N   . VAL A 1 349 ? 176.19800 346.11600 40.98100  1.000 26.14123  ? 384 VAL F N   1 
ATOM   2472 C CA  . VAL A 1 349 ? 175.78900 346.38800 42.34500  1.000 26.09589  ? 384 VAL F CA  1 
ATOM   2473 C C   . VAL A 1 349 ? 176.54600 347.54000 42.98900  1.000 26.45602  ? 384 VAL F C   1 
ATOM   2474 O O   . VAL A 1 349 ? 175.93400 348.35200 43.68400  1.000 34.51741  ? 384 VAL F O   1 
ATOM   2475 C CB  . VAL A 1 349 ? 176.09000 345.09700 43.14600  1.000 28.67101  ? 384 VAL F CB  1 
ATOM   2476 C CG1 . VAL A 1 349 ? 176.06400 345.31200 44.67300  1.000 27.91946  ? 384 VAL F CG1 1 
ATOM   2477 C CG2 . VAL A 1 349 ? 175.20200 343.94300 42.69700  1.000 29.21924  ? 384 VAL F CG2 1 
ATOM   2478 N N   . ASP A 1 350 ? 177.82300 347.69500 42.64900  1.000 23.51659  ? 385 ASP F N   1 
ATOM   2479 C CA  . ASP A 1 350 ? 178.71400 348.75000 43.15200  1.000 26.23256  ? 385 ASP F CA  1 
ATOM   2480 C C   . ASP A 1 350 ? 179.71200 349.10900 42.04900  1.000 27.01383  ? 385 ASP F C   1 
ATOM   2481 O O   . ASP A 1 350 ? 180.75900 348.45700 41.96100  1.000 22.25042  ? 385 ASP F O   1 
ATOM   2482 C CB  . ASP A 1 350 ? 179.38100 348.38500 44.46800  1.000 32.66344  ? 385 ASP F CB  1 
ATOM   2483 C CG  . ASP A 1 350 ? 180.27700 349.49200 44.97300  1.000 35.08068  ? 385 ASP F CG  1 
ATOM   2484 O OD1 . ASP A 1 350 ? 180.07000 350.65800 44.53700  1.000 33.74499  ? 385 ASP F OD1 1 
ATOM   2485 O OD2 . ASP A 1 350 ? 181.12900 349.21400 45.85000  1.000 45.09730  ? 385 ASP F OD2 1 
ATOM   2486 N N   . ILE A 1 351 ? 179.50200 350.20100 41.31300  1.000 25.68241  ? 386 ILE F N   1 
ATOM   2487 C CA  . ILE A 1 351 ? 180.42100 350.38600 40.19000  1.000 19.96189  ? 386 ILE F CA  1 
ATOM   2488 C C   . ILE A 1 351 ? 181.80900 350.77500 40.68000  1.000 23.86215  ? 386 ILE F C   1 
ATOM   2489 O O   . ILE A 1 351 ? 182.77800 350.67100 39.91700  1.000 22.74929  ? 386 ILE F O   1 
ATOM   2490 C CB  . ILE A 1 351 ? 179.83100 351.38800 39.18400  1.000 22.06981  ? 386 ILE F CB  1 
ATOM   2491 C CG1 . ILE A 1 351 ? 180.64400 351.33200 37.88700  1.000 20.10406  ? 386 ILE F CG1 1 
ATOM   2492 C CG2 . ILE A 1 351 ? 179.81600 352.77700 39.76500  1.000 20.52167  ? 386 ILE F CG2 1 
ATOM   2493 C CD1 . ILE A 1 351 ? 180.13400 352.16800 36.80800  1.000 20.23137  ? 386 ILE F CD1 1 
ATOM   2494 N N   . PHE A 1 352 ? 181.91000 351.28800 41.89900  1.000 24.05202  ? 387 PHE F N   1 
ATOM   2495 C CA  . PHE A 1 352 ? 183.10300 351.73600 42.62800  1.000 27.14733  ? 387 PHE F CA  1 
ATOM   2496 C C   . PHE A 1 352 ? 183.77600 350.58000 43.39200  1.000 28.68207  ? 387 PHE F C   1 
ATOM   2497 O O   . PHE A 1 352 ? 184.78600 350.80400 44.06100  1.000 38.38565  ? 387 PHE F O   1 
ATOM   2498 C CB  . PHE A 1 352 ? 182.74200 352.89400 43.56100  1.000 24.95477  ? 387 PHE F CB  1 
ATOM   2499 C CG  . PHE A 1 352 ? 182.49900 354.15300 42.82200  1.000 25.84054  ? 387 PHE F CG  1 
ATOM   2500 C CD1 . PHE A 1 352 ? 183.38400 354.55500 41.83600  1.000 26.42941  ? 387 PHE F CD1 1 
ATOM   2501 C CD2 . PHE A 1 352 ? 181.28900 354.79900 42.92800  1.000 23.63022  ? 387 PHE F CD2 1 
ATOM   2502 C CE1 . PHE A 1 352 ? 183.14000 355.68500 41.09100  1.000 28.53884  ? 387 PHE F CE1 1 
ATOM   2503 C CE2 . PHE A 1 352 ? 181.02000 355.92000 42.15900  1.000 24.60248  ? 387 PHE F CE2 1 
ATOM   2504 C CZ  . PHE A 1 352 ? 181.94100 356.35600 41.24100  1.000 21.65835  ? 387 PHE F CZ  1 
ATOM   2505 N N   . ASN A 1 353 ? 183.40100 349.34700 43.11100  1.000 27.86545  ? 388 ASN F N   1 
ATOM   2506 C CA  . ASN A 1 353 ? 183.82400 348.13900 43.83900  1.000 29.79292  ? 388 ASN F CA  1 
ATOM   2507 C C   . ASN A 1 353 ? 185.21300 347.70400 43.41600  1.000 28.52504  ? 388 ASN F C   1 
ATOM   2508 O O   . ASN A 1 353 ? 185.56300 347.83200 42.24100  1.000 31.95112  ? 388 ASN F O   1 
ATOM   2509 C CB  . ASN A 1 353 ? 182.89000 346.96700 43.57500  1.000 22.06221  ? 388 ASN F CB  1 
ATOM   2510 C CG  . ASN A 1 353 ? 183.26400 346.23800 42.28000  1.000 27.47014  ? 388 ASN F CG  1 
ATOM   2511 O OD1 . ASN A 1 353 ? 184.09300 345.32400 42.28000  1.000 26.48927  ? 388 ASN F OD1 1 
ATOM   2512 N ND2 . ASN A 1 353 ? 182.70600 346.70200 41.15300  1.000 24.72682  ? 388 ASN F ND2 1 
ATOM   2513 N N   . PRO A 1 354 ? 186.12000 347.53000 44.37600  1.000 35.02147  ? 389 PRO F N   1 
ATOM   2514 C CA  . PRO A 1 354 ? 187.47400 347.13100 44.01100  1.000 30.48707  ? 389 PRO F CA  1 
ATOM   2515 C C   . PRO A 1 354 ? 187.65100 345.71600 43.46500  1.000 32.10647  ? 389 PRO F C   1 
ATOM   2516 O O   . PRO A 1 354 ? 188.76700 345.42500 43.02200  1.000 38.34768  ? 389 PRO F O   1 
ATOM   2517 C CB  . PRO A 1 354 ? 188.21000 347.25900 45.34800  1.000 34.21571  ? 389 PRO F CB  1 
ATOM   2518 C CG  . PRO A 1 354 ? 187.14900 346.76600 46.37800  1.000 30.44933  ? 389 PRO F CG  1 
ATOM   2519 C CD  . PRO A 1 354 ? 185.77300 347.07300 45.74300  1.000 30.59396  ? 389 PRO F CD  1 
ATOM   2520 N N   . LYS A 1 355 ? 186.68400 344.79500 43.51900  1.000 28.11399  ? 390 LYS F N   1 
ATOM   2521 C CA  . LYS A 1 355 ? 187.03700 343.49100 42.94500  1.000 25.36834  ? 390 LYS F CA  1 
ATOM   2522 C C   . LYS A 1 355 ? 187.10000 343.47100 41.40500  1.000 32.00646  ? 390 LYS F C   1 
ATOM   2523 O O   . LYS A 1 355 ? 187.87900 342.70400 40.82600  1.000 29.53735  ? 390 LYS F O   1 
ATOM   2524 C CB  . LYS A 1 355 ? 186.04100 342.45700 43.45000  1.000 25.13707  ? 390 LYS F CB  1 
ATOM   2525 C CG  . LYS A 1 355 ? 186.15200 342.20700 44.95700  1.000 29.66789  ? 390 LYS F CG  1 
ATOM   2526 C CD  . LYS A 1 355 ? 185.11100 341.17200 45.40800  1.000 35.84500  ? 390 LYS F CD  1 
ATOM   2527 C CE  . LYS A 1 355 ? 185.73300 339.95700 46.03400  1.000 49.81067  ? 390 LYS F CE  1 
ATOM   2528 N NZ  . LYS A 1 355 ? 184.69300 338.97200 46.45800  1.000 52.02436  ? 390 LYS F NZ  1 
ATOM   2529 N N   . TYR A 1 356 ? 186.31600 344.30800 40.71200  1.000 25.60949  ? 391 TYR F N   1 
ATOM   2530 C CA  . TYR A 1 356 ? 186.38300 344.36200 39.25500  1.000 23.23488  ? 391 TYR F CA  1 
ATOM   2531 C C   . TYR A 1 356 ? 186.40800 345.80500 38.77200  1.000 22.72194  ? 391 TYR F C   1 
ATOM   2532 O O   . TYR A 1 356 ? 185.60200 346.61200 39.23500  1.000 25.41705  ? 391 TYR F O   1 
ATOM   2533 C CB  . TYR A 1 356 ? 185.19600 343.57400 38.65300  1.000 20.27730  ? 391 TYR F CB  1 
ATOM   2534 C CG  . TYR A 1 356 ? 185.17600 343.50900 37.15000  1.000 24.09376  ? 391 TYR F CG  1 
ATOM   2535 C CD1 . TYR A 1 356 ? 184.65700 344.56200 36.39400  1.000 19.96860  ? 391 TYR F CD1 1 
ATOM   2536 C CD2 . TYR A 1 356 ? 185.71500 342.42000 36.46900  1.000 23.92881  ? 391 TYR F CD2 1 
ATOM   2537 C CE1 . TYR A 1 356 ? 184.65800 344.50800 35.01900  1.000 22.01038  ? 391 TYR F CE1 1 
ATOM   2538 C CE2 . TYR A 1 356 ? 185.70900 342.36600 35.08500  1.000 15.96042  ? 391 TYR F CE2 1 
ATOM   2539 C CZ  . TYR A 1 356 ? 185.18300 343.40500 34.36500  1.000 23.75385  ? 391 TYR F CZ  1 
ATOM   2540 O OH  . TYR A 1 356 ? 185.17200 343.36300 32.98400  1.000 27.12028  ? 391 TYR F OH  1 
ATOM   2541 N N   . ASP A 1 357 ? 187.32700 346.14000 37.87500  1.000 25.04359  ? 392 ASP F N   1 
ATOM   2542 C CA  . ASP A 1 357 ? 187.45200 347.50500 37.36000  1.000 26.32572  ? 392 ASP F CA  1 
ATOM   2543 C C   . ASP A 1 357 ? 186.40700 347.82400 36.27900  1.000 18.14739  ? 392 ASP F C   1 
ATOM   2544 O O   . ASP A 1 357 ? 186.66900 347.69400 35.09000  1.000 20.18863  ? 392 ASP F O   1 
ATOM   2545 C CB  . ASP A 1 357 ? 188.86100 347.77100 36.87700  1.000 27.38153  ? 392 ASP F CB  1 
ATOM   2546 C CG  . ASP A 1 357 ? 189.08700 349.24200 36.66000  1.000 31.15609  ? 392 ASP F CG  1 
ATOM   2547 O OD1 . ASP A 1 357 ? 188.32000 350.03800 37.27000  1.000 25.45371  ? 392 ASP F OD1 1 
ATOM   2548 O OD2 . ASP A 1 357 ? 190.00200 349.59400 35.88600  1.000 25.83008  ? 392 ASP F OD2 1 
ATOM   2549 N N   . CYS A 1 358 ? 185.20200 348.19900 36.70000  1.000 23.19162  ? 393 CYS F N   1 
ATOM   2550 C CA  . CYS A 1 358 ? 184.07500 348.68700 35.88800  1.000 23.74377  ? 393 CYS F CA  1 
ATOM   2551 C C   . CYS A 1 358 ? 184.41800 349.65800 34.76200  1.000 20.11293  ? 393 CYS F C   1 
ATOM   2552 O O   . CYS A 1 358 ? 185.09800 350.65600 34.98700  1.000 20.30143  ? 393 CYS F O   1 
ATOM   2553 C CB  . CYS A 1 358 ? 182.95600 349.23300 36.76300  1.000 27.59556  ? 393 CYS F CB  1 
ATOM   2554 S SG  . CYS A 1 358 ? 182.46900 347.90200 37.91500  1.000 27.65587  ? 393 CYS F SG  1 
ATOM   2555 N N   . LYS A 1 359 ? 184.17500 349.25200 33.51500  1.000 16.98502  ? 394 LYS F N   1 
ATOM   2556 C CA  . LYS A 1 359 ? 184.65000 350.02700 32.38800  1.000 30.21909  ? 394 LYS F CA  1 
ATOM   2557 C C   . LYS A 1 359 ? 183.60600 351.07100 31.95200  1.000 26.63039  ? 394 LYS F C   1 
ATOM   2558 O O   . LYS A 1 359 ? 182.38700 350.84600 32.01400  1.000 20.15105  ? 394 LYS F O   1 
ATOM   2559 C CB  . LYS A 1 359 ? 184.83700 349.02800 31.23600  1.000 31.61913  ? 394 LYS F CB  1 
ATOM   2560 C CG  . LYS A 1 359 ? 185.87400 347.91900 31.55000  1.000 29.23905  ? 394 LYS F CG  1 
ATOM   2561 C CD  . LYS A 1 359 ? 185.89600 346.85700 30.47600  1.000 40.48791  ? 394 LYS F CD  1 
ATOM   2562 C CE  . LYS A 1 359 ? 186.83200 347.28800 29.35600  1.000 47.33080  ? 394 LYS F CE  1 
ATOM   2563 N NZ  . LYS A 1 359 ? 187.95400 348.07200 29.97300  1.000 46.92540  ? 394 LYS F NZ  1 
ATOM   2564 N N   . ILE A 1 360 ? 184.10700 352.24800 31.57200  1.000 18.12378  ? 395 ILE F N   1 
ATOM   2565 C CA  . ILE A 1 360 ? 183.29800 353.36500 31.10000  1.000 21.25851  ? 395 ILE F CA  1 
ATOM   2566 C C   . ILE A 1 360 ? 184.00600 354.06500 29.95100  1.000 21.24268  ? 395 ILE F C   1 
ATOM   2567 O O   . ILE A 1 360 ? 185.22500 353.99300 29.81900  1.000 22.26147  ? 395 ILE F O   1 
ATOM   2568 C CB  . ILE A 1 360 ? 182.97300 354.33100 32.24900  1.000 19.17496  ? 395 ILE F CB  1 
ATOM   2569 C CG1 . ILE A 1 360 ? 184.26700 354.92900 32.79500  1.000 20.28456  ? 395 ILE F CG1 1 
ATOM   2570 C CG2 . ILE A 1 360 ? 182.13500 353.65100 33.30300  1.000 18.05117  ? 395 ILE F CG2 1 
ATOM   2571 C CD1 . ILE A 1 360 ? 184.08000 356.14700 33.65400  1.000 23.18031  ? 395 ILE F CD1 1 
ATOM   2572 N N   . MET A 1 361 ? 183.25700 354.90800 29.25300  1.000 16.48568  ? 396 MET F N   1 
ATOM   2573 C CA  . MET A 1 361 ? 183.79900 355.83200 28.27300  1.000 18.62534  ? 396 MET F CA  1 
ATOM   2574 C C   . MET A 1 361 ? 183.26800 357.21700 28.61700  1.000 17.02918  ? 396 MET F C   1 
ATOM   2575 O O   . MET A 1 361 ? 182.18400 357.33800 29.19600  1.000 18.48286  ? 396 MET F O   1 
ATOM   2576 C CB  . MET A 1 361 ? 183.51300 355.39600 26.82500  1.000 19.03285  ? 396 MET F CB  1 
ATOM   2577 C CG  . MET A 1 361 ? 182.12500 355.28300 26.35600  1.000 25.52371  ? 396 MET F CG  1 
ATOM   2578 S SD  . MET A 1 361 ? 181.69800 356.86000 25.58900  1.000 46.68062  ? 396 MET F SD  1 
ATOM   2579 C CE  . MET A 1 361 ? 181.83100 356.34300 23.88200  1.000 37.03894  ? 396 MET F CE  1 
ATOM   2580 N N   . THR A 1 362 ? 184.05800 358.26300 28.34600  1.000 14.63511  ? 397 THR F N   1 
ATOM   2581 C CA  . THR A 1 362 ? 183.64400 359.60200 28.76600  1.000 17.71072  ? 397 THR F CA  1 
ATOM   2582 C C   . THR A 1 362 ? 183.49500 360.63700 27.64000  1.000 21.46119  ? 397 THR F C   1 
ATOM   2583 O O   . THR A 1 362 ? 183.63700 361.82700 27.86700  1.000 25.60160  ? 397 THR F O   1 
ATOM   2584 C CB  . THR A 1 362 ? 184.62900 360.14100 29.80000  1.000 16.58028  ? 397 THR F CB  1 
ATOM   2585 O OG1 . THR A 1 362 ? 185.92200 360.23000 29.20500  1.000 17.10174  ? 397 THR F OG1 1 
ATOM   2586 C CG2 . THR A 1 362 ? 184.71400 359.18700 31.04500  1.000 13.04311  ? 397 THR F CG2 1 
ATOM   2587 N N   . SER A 1 363 ? 183.20300 360.24400 26.42600  1.000 22.76647  ? 398 SER F N   1 
ATOM   2588 C CA  . SER A 1 363 ? 182.98100 361.26600 25.40400  1.000 36.11056  ? 398 SER F CA  1 
ATOM   2589 C C   . SER A 1 363 ? 181.80700 362.15900 25.81900  1.000 29.21544  ? 398 SER F C   1 
ATOM   2590 O O   . SER A 1 363 ? 180.78000 361.65000 26.26200  1.000 30.42175  ? 398 SER F O   1 
ATOM   2591 C CB  . SER A 1 363 ? 182.67900 360.59100 24.06100  1.000 33.10090  ? 398 SER F CB  1 
ATOM   2592 O OG  . SER A 1 363 ? 183.84900 359.95100 23.57200  1.000 50.05232  ? 398 SER F OG  1 
ATOM   2593 N N   . LYS A 1 364 ? 181.93700 363.48600 25.66600  1.000 32.35329  ? 399 LYS F N   1 
ATOM   2594 C CA  . LYS A 1 364 ? 180.78900 364.37000 25.90300  1.000 36.34721  ? 399 LYS F CA  1 
ATOM   2595 C C   . LYS A 1 364 ? 179.66200 364.12300 24.89000  1.000 33.86978  ? 399 LYS F C   1 
ATOM   2596 O O   . LYS A 1 364 ? 179.88500 363.72400 23.74300  1.000 36.33270  ? 399 LYS F O   1 
ATOM   2597 C CB  . LYS A 1 364 ? 181.20300 365.84300 25.87300  1.000 31.53469  ? 399 LYS F CB  1 
ATOM   2598 C CG  . LYS A 1 364 ? 182.19000 366.24200 26.98000  1.000 37.16227  ? 399 LYS F CG  1 
ATOM   2599 C CD  . LYS A 1 364 ? 182.72400 367.65700 26.77000  1.000 30.04120  ? 399 LYS F CD  1 
ATOM   2600 C CE  . LYS A 1 364 ? 183.31700 368.34200 28.01500  1.000 39.23303  ? 399 LYS F CE  1 
ATOM   2601 N NZ  . LYS A 1 364 ? 182.83600 369.77400 28.21800  1.000 35.87305  ? 399 LYS F NZ  1 
ATOM   2602 N N   . THR A 1 365 ? 178.43000 364.38300 25.32300  1.000 35.50362  ? 400 THR F N   1 
ATOM   2603 C CA  . THR A 1 365 ? 177.26000 364.09200 24.49700  1.000 27.12460  ? 400 THR F CA  1 
ATOM   2604 C C   . THR A 1 365 ? 176.03400 364.88900 24.93700  1.000 36.61650  ? 400 THR F C   1 
ATOM   2605 O O   . THR A 1 365 ? 175.45500 364.60200 25.98700  1.000 46.36872  ? 400 THR F O   1 
ATOM   2606 C CB  . THR A 1 365 ? 176.89800 362.63200 24.42600  1.000 39.78100  ? 400 THR F CB  1 
ATOM   2607 O OG1 . THR A 1 365 ? 175.79600 362.54700 23.51500  1.000 46.35132  ? 400 THR F OG1 1 
ATOM   2608 C CG2 . THR A 1 365 ? 176.40900 362.13000 25.76400  1.000 34.72062  ? 400 THR F CG2 1 
ATOM   2609 N N   . ASP A 1 366 ? 175.78200 365.98800 24.27200  1.000 38.55716  ? 401 ASP F N   1 
ATOM   2610 C CA  . ASP A 1 366 ? 174.60300 366.75500 24.63000  1.000 43.76565  ? 401 ASP F CA  1 
ATOM   2611 C C   . ASP A 1 366 ? 173.41400 366.36600 23.74300  1.000 43.61565  ? 401 ASP F C   1 
ATOM   2612 O O   . ASP A 1 366 ? 172.51100 367.19700 23.50200  1.000 36.55741  ? 401 ASP F O   1 
ATOM   2613 C CB  . ASP A 1 366 ? 174.90100 368.25200 24.54300  1.000 44.64389  ? 401 ASP F CB  1 
ATOM   2614 C CG  . ASP A 1 366 ? 175.74800 368.72700 25.69600  1.000 52.14144  ? 401 ASP F CG  1 
ATOM   2615 O OD1 . ASP A 1 366 ? 175.58600 368.10200 26.78900  1.000 59.02106  ? 401 ASP F OD1 1 
ATOM   2616 O OD2 . ASP A 1 366 ? 176.49200 369.73600 25.53500  1.000 68.19469  ? 401 ASP F OD2 1 
ATOM   2617 N N   . VAL A 1 367 ? 173.40000 365.10800 23.25500  1.000 34.32834  ? 402 VAL F N   1 
ATOM   2618 C CA  . VAL A 1 367 ? 172.30800 364.56700 22.44400  1.000 24.81517  ? 402 VAL F CA  1 
ATOM   2619 C C   . VAL A 1 367 ? 171.50400 363.51900 23.21700  1.000 20.28192  ? 402 VAL F C   1 
ATOM   2620 O O   . VAL A 1 367 ? 172.06000 362.69700 23.95600  1.000 20.77643  ? 402 VAL F O   1 
ATOM   2621 C CB  . VAL A 1 367 ? 172.86100 363.92900 21.15700  1.000 27.47103  ? 402 VAL F CB  1 
ATOM   2622 C CG1 . VAL A 1 367 ? 171.73400 363.35000 20.35100  1.000 19.91416  ? 402 VAL F CG1 1 
ATOM   2623 C CG2 . VAL A 1 367 ? 173.70300 364.92300 20.33800  1.000 26.75398  ? 402 VAL F CG2 1 
ATOM   2624 N N   . SER A 1 368 ? 170.19000 363.64000 23.13100  1.000 16.69003  ? 403 SER F N   1 
ATOM   2625 C CA  . SER A 1 368 ? 169.22100 362.78100 23.80000  1.000 20.21260  ? 403 SER F CA  1 
ATOM   2626 C C   . SER A 1 368 ? 169.12800 361.41300 23.12400  1.000 17.94217  ? 403 SER F C   1 
ATOM   2627 O O   . SER A 1 368 ? 169.24300 361.31900 21.90300  1.000 18.50630  ? 403 SER F O   1 
ATOM   2628 C CB  . SER A 1 368 ? 167.86400 363.47100 23.82900  1.000 14.70037  ? 403 SER F CB  1 
ATOM   2629 O OG  . SER A 1 368 ? 167.98300 364.64600 24.59900  1.000 16.99770  ? 403 SER F OG  1 
ATOM   2630 N N   . SER A 1 369 ? 168.80400 360.36900 23.89800  1.000 15.23962  ? 404 SER F N   1 
ATOM   2631 C CA  . SER A 1 369 ? 168.63600 359.03500 23.32700  1.000 17.77310  ? 404 SER F CA  1 
ATOM   2632 C C   . SER A 1 369 ? 167.81500 358.17900 24.28700  1.000 16.22233  ? 404 SER F C   1 
ATOM   2633 O O   . SER A 1 369 ? 167.67800 358.48200 25.46600  1.000 17.23055  ? 404 SER F O   1 
ATOM   2634 C CB  . SER A 1 369 ? 169.97600 358.37200 22.99300  1.000 18.33927  ? 404 SER F CB  1 
ATOM   2635 O OG  . SER A 1 369 ? 170.75700 358.25400 24.17100  1.000 25.06046  ? 404 SER F OG  1 
ATOM   2636 N N   . SER A 1 370 ? 167.37900 357.03400 23.79300  1.000 20.45364  ? 405 SER F N   1 
ATOM   2637 C CA  . SER A 1 370 ? 166.60800 356.09900 24.58800  1.000 19.07015  ? 405 SER F CA  1 
ATOM   2638 C C   . SER A 1 370 ? 167.00500 354.65900 24.28300  1.000 21.05298  ? 405 SER F C   1 
ATOM   2639 O O   . SER A 1 370 ? 167.48900 354.35300 23.19700  1.000 19.42662  ? 405 SER F O   1 
ATOM   2640 C CB  . SER A 1 370 ? 165.11200 356.28200 24.29000  1.000 20.74409  ? 405 SER F CB  1 
ATOM   2641 O OG  . SER A 1 370 ? 164.32500 355.38800 25.07100  1.000 28.59809  ? 405 SER F OG  1 
ATOM   2642 N N   . VAL A 1 371 ? 166.82100 353.78800 25.26600  1.000 17.83103  ? 406 VAL F N   1 
ATOM   2643 C CA  . VAL A 1 371 ? 167.09300 352.37000 25.11000  1.000 20.02430  ? 406 VAL F CA  1 
ATOM   2644 C C   . VAL A 1 371 ? 165.85800 351.62700 25.57400  1.000 19.06198  ? 406 VAL F C   1 
ATOM   2645 O O   . VAL A 1 371 ? 165.42100 351.80500 26.71400  1.000 17.62672  ? 406 VAL F O   1 
ATOM   2646 C CB  . VAL A 1 371 ? 168.31500 351.90700 25.93300  1.000 22.20118  ? 406 VAL F CB  1 
ATOM   2647 C CG1 . VAL A 1 371 ? 168.49000 350.41300 25.77400  1.000 22.99895  ? 406 VAL F CG1 1 
ATOM   2648 C CG2 . VAL A 1 371 ? 169.57900 352.60600 25.47700  1.000 20.25568  ? 406 VAL F CG2 1 
ATOM   2649 N N   . ILE A 1 372 ? 165.27800 350.83200 24.68600  1.000 15.79530  ? 407 ILE F N   1 
ATOM   2650 C CA  . ILE A 1 372 ? 164.14300 349.98600 25.03600  1.000 18.26080  ? 407 ILE F CA  1 
ATOM   2651 C C   . ILE A 1 372 ? 164.67800 348.71000 25.69300  1.000 17.94403  ? 407 ILE F C   1 
ATOM   2652 O O   . ILE A 1 372 ? 165.47100 347.98000 25.09400  1.000 19.37536  ? 407 ILE F O   1 
ATOM   2653 C CB  . ILE A 1 372 ? 163.28800 349.66400 23.80300  1.000 17.07324  ? 407 ILE F CB  1 
ATOM   2654 C CG1 . ILE A 1 372 ? 162.69300 350.96400 23.21600  1.000 17.95588  ? 407 ILE F CG1 1 
ATOM   2655 C CG2 . ILE A 1 372 ? 162.22800 348.63900 24.15900  1.000 22.03110  ? 407 ILE F CG2 1 
ATOM   2656 C CD1 . ILE A 1 372 ? 161.83000 351.78300 24.17000  1.000 17.24681  ? 407 ILE F CD1 1 
ATOM   2657 N N   . THR A 1 373 ? 164.34100 348.49400 26.94600  1.000 20.38546  ? 408 THR F N   1 
ATOM   2658 C CA  . THR A 1 373 ? 164.78500 347.32300 27.70100  1.000 19.17925  ? 408 THR F CA  1 
ATOM   2659 C C   . THR A 1 373 ? 163.75900 346.18700 27.64800  1.000 19.73689  ? 408 THR F C   1 
ATOM   2660 O O   . THR A 1 373 ? 162.82000 346.19500 26.85200  1.000 22.68075  ? 408 THR F O   1 
ATOM   2661 C CB  . THR A 1 373 ? 165.07700 347.74000 29.13000  1.000 18.81389  ? 408 THR F CB  1 
ATOM   2662 O OG1 . THR A 1 373 ? 163.82800 348.07800 29.75300  1.000 19.69511  ? 408 THR F OG1 1 
ATOM   2663 C CG2 . THR A 1 373 ? 166.01000 348.93200 29.12100  1.000 15.98611  ? 408 THR F CG2 1 
ATOM   2664 N N   . SER A 1 374 ? 163.93500 345.16400 28.48500  1.000 18.22638  ? 409 SER F N   1 
ATOM   2665 C CA  . SER A 1 374 ? 162.97400 344.07000 28.42700  1.000 18.60241  ? 409 SER F CA  1 
ATOM   2666 C C   . SER A 1 374 ? 161.66600 344.47400 29.06500  1.000 18.79376  ? 409 SER F C   1 
ATOM   2667 O O   . SER A 1 374 ? 160.60800 344.01600 28.63500  1.000 22.93016  ? 409 SER F O   1 
ATOM   2668 C CB  . SER A 1 374 ? 163.47300 342.80100 29.14800  1.000 18.62862  ? 409 SER F CB  1 
ATOM   2669 O OG  . SER A 1 374 ? 164.74500 342.37000 28.70700  1.000 24.77034  ? 409 SER F OG  1 
ATOM   2670 N N   . LEU A 1 375 ? 161.70800 345.31500 30.09500  1.000 19.44752  ? 410 LEU F N   1 
ATOM   2671 C CA  . LEU A 1 375 ? 160.49100 345.68000 30.81500  1.000 19.62430  ? 410 LEU F CA  1 
ATOM   2672 C C   . LEU A 1 375 ? 160.25100 347.18500 30.93800  1.000 20.60841  ? 410 LEU F C   1 
ATOM   2673 O O   . LEU A 1 375 ? 159.45300 347.59600 31.78100  1.000 21.20573  ? 410 LEU F O   1 
ATOM   2674 C CB  . LEU A 1 375 ? 160.52600 345.06400 32.21700  1.000 18.11477  ? 410 LEU F CB  1 
ATOM   2675 C CG  . LEU A 1 375 ? 160.58400 343.53600 32.30500  1.000 22.72332  ? 410 LEU F CG  1 
ATOM   2676 C CD1 . LEU A 1 375 ? 160.71500 343.07700 33.77600  1.000 22.14984  ? 410 LEU F CD1 1 
ATOM   2677 C CD2 . LEU A 1 375 ? 159.35500 342.95600 31.64600  1.000 21.08691  ? 410 LEU F CD2 1 
ATOM   2678 N N   . GLY A 1 376 ? 160.91800 348.02000 30.14000  1.000 19.68848  ? 411 GLY F N   1 
ATOM   2679 C CA  . GLY A 1 376 ? 160.72600 349.45300 30.25900  1.000 16.42078  ? 411 GLY F CA  1 
ATOM   2680 C C   . GLY A 1 376 ? 161.59800 350.20800 29.28400  1.000 16.70480  ? 411 GLY F C   1 
ATOM   2681 O O   . GLY A 1 376 ? 161.77800 349.77900 28.14200  1.000 15.72714  ? 411 GLY F O   1 
ATOM   2682 N N   . ALA A 1 377 ? 162.08500 351.37100 29.69000  1.000 13.57660  ? 412 ALA F N   1 
ATOM   2683 C CA  . ALA A 1 377 ? 162.90100 352.17400 28.78700  1.000 15.34351  ? 412 ALA F CA  1 
ATOM   2684 C C   . ALA A 1 377 ? 163.75600 353.13700 29.58900  1.000 13.74821  ? 412 ALA F C   1 
ATOM   2685 O O   . ALA A 1 377 ? 163.28100 353.71200 30.57400  1.000 14.38129  ? 412 ALA F O   1 
ATOM   2686 C CB  . ALA A 1 377 ? 162.05200 352.94200 27.76900  1.000 15.58022  ? 412 ALA F CB  1 
ATOM   2687 N N   . ILE A 1 378 ? 165.04300 353.19700 29.24400  1.000 14.67011  ? 413 ILE F N   1 
ATOM   2688 C CA  . ILE A 1 378 ? 165.95100 354.21200 29.75500  1.000 14.68271  ? 413 ILE F CA  1 
ATOM   2689 C C   . ILE A 1 378 ? 165.91300 355.39100 28.80700  1.000 13.23464  ? 413 ILE F C   1 
ATOM   2690 O O   . ILE A 1 378 ? 165.88300 355.20800 27.59500  1.000 16.46382  ? 413 ILE F O   1 
ATOM   2691 C CB  . ILE A 1 378 ? 167.40000 353.69500 29.88800  1.000 17.47438  ? 413 ILE F CB  1 
ATOM   2692 C CG1 . ILE A 1 378 ? 167.48300 352.38900 30.67700  1.000 16.58778  ? 413 ILE F CG1 1 
ATOM   2693 C CG2 . ILE A 1 378 ? 168.34100 354.81000 30.38700  1.000 15.25996  ? 413 ILE F CG2 1 
ATOM   2694 C CD1 . ILE A 1 378 ? 168.94300 351.81700 30.72400  1.000 15.96647  ? 413 ILE F CD1 1 
ATOM   2695 N N   . VAL A 1 379 ? 165.87100 356.59700 29.35500  1.000 14.77963  ? 414 VAL F N   1 
ATOM   2696 C CA  . VAL A 1 379 ? 165.83000 357.83100 28.57600  1.000 13.84529  ? 414 VAL F CA  1 
ATOM   2697 C C   . VAL A 1 379 ? 166.93500 358.73700 29.09300  1.000 14.74330  ? 414 VAL F C   1 
ATOM   2698 O O   . VAL A 1 379 ? 167.00300 358.99800 30.29700  1.000 16.26012  ? 414 VAL F O   1 
ATOM   2699 C CB  . VAL A 1 379 ? 164.47300 358.56200 28.61900  1.000 18.18679  ? 414 VAL F CB  1 
ATOM   2700 C CG1 . VAL A 1 379 ? 164.60300 359.91600 27.88000  1.000 16.35150  ? 414 VAL F CG1 1 
ATOM   2701 C CG2 . VAL A 1 379 ? 163.41300 357.76400 27.91600  1.000 16.93713  ? 414 VAL F CG2 1 
ATOM   2702 N N   . SER A 1 380 ? 167.83500 359.15100 28.21200  1.000 12.13199  ? 415 SER F N   1 
ATOM   2703 C CA  . SER A 1 380 ? 168.85000 360.15000 28.50600  1.000 13.07012  ? 415 SER F CA  1 
ATOM   2704 C C   . SER A 1 380 ? 168.38700 361.40300 27.77300  1.000 14.35633  ? 415 SER F C   1 
ATOM   2705 O O   . SER A 1 380 ? 168.45600 361.47200 26.53700  1.000 13.43731  ? 415 SER F O   1 
ATOM   2706 C CB  . SER A 1 380 ? 170.25600 359.73900 28.04700  1.000 14.84403  ? 415 SER F CB  1 
ATOM   2707 O OG  . SER A 1 380 ? 170.72800 358.56900 28.69600  1.000 18.24840  ? 415 SER F OG  1 
ATOM   2708 N N   . CYS A 1 381 ? 167.89300 362.37000 28.52900  1.000 12.40075  ? 416 CYS F N   1 
ATOM   2709 C CA  . CYS A 1 381 ? 167.31000 363.59200 27.98900  1.000 17.54598  ? 416 CYS F CA  1 
ATOM   2710 C C   . CYS A 1 381 ? 168.25400 364.73100 28.31600  1.000 15.11534  ? 416 CYS F C   1 
ATOM   2711 O O   . CYS A 1 381 ? 168.49200 365.02100 29.49100  1.000 17.97258  ? 416 CYS F O   1 
ATOM   2712 C CB  . CYS A 1 381 ? 165.93000 363.84800 28.61300  1.000 18.11069  ? 416 CYS F CB  1 
ATOM   2713 S SG  . CYS A 1 381 ? 164.78500 364.87000 27.62200  1.000 27.66659  ? 416 CYS F SG  1 
ATOM   2714 N N   . TYR A 1 382 ? 168.67000 365.45500 27.28900  1.000 15.35962  ? 417 TYR F N   1 
ATOM   2715 C CA  . TYR A 1 382 ? 169.61200 366.55600 27.45000  1.000 17.90792  ? 417 TYR F CA  1 
ATOM   2716 C C   . TYR A 1 382 ? 169.26700 367.68600 26.50600  1.000 17.07154  ? 417 TYR F C   1 
ATOM   2717 O O   . TYR A 1 382 ? 168.52200 367.49600 25.54800  1.000 17.69441  ? 417 TYR F O   1 
ATOM   2718 C CB  . TYR A 1 382 ? 171.08000 366.14700 27.24400  1.000 15.48662  ? 417 TYR F CB  1 
ATOM   2719 C CG  . TYR A 1 382 ? 171.45100 364.98700 28.12500  1.000 18.81546  ? 417 TYR F CG  1 
ATOM   2720 C CD1 . TYR A 1 382 ? 171.60300 365.18100 29.50000  1.000 16.73859  ? 417 TYR F CD1 1 
ATOM   2721 C CD2 . TYR A 1 382 ? 171.78700 363.74100 27.58500  1.000 17.20846  ? 417 TYR F CD2 1 
ATOM   2722 C CE1 . TYR A 1 382 ? 171.95200 364.14100 30.33200  1.000 16.86168  ? 417 TYR F CE1 1 
ATOM   2723 C CE2 . TYR A 1 382 ? 172.17200 362.69700 28.39500  1.000 16.66966  ? 417 TYR F CE2 1 
ATOM   2724 C CZ  . TYR A 1 382 ? 172.22600 362.89900 29.77400  1.000 20.23381  ? 417 TYR F CZ  1 
ATOM   2725 O OH  . TYR A 1 382 ? 172.57300 361.87200 30.59900  1.000 17.87293  ? 417 TYR F OH  1 
ATOM   2726 N N   . GLY A 1 383 ? 169.63600 368.90000 26.91100  1.000 23.19951  ? 418 GLY F N   1 
ATOM   2727 C CA  . GLY A 1 383 ? 169.38800 370.04000 26.05400  1.000 19.01651  ? 418 GLY F CA  1 
ATOM   2728 C C   . GLY A 1 383 ? 167.92000 370.40100 26.09800  1.000 18.31761  ? 418 GLY F C   1 
ATOM   2729 O O   . GLY A 1 383 ? 167.27500 370.36500 27.14900  1.000 19.74102  ? 418 GLY F O   1 
ATOM   2730 N N   . LYS A 1 384 ? 167.38600 370.75700 24.94600  1.000 15.67868  ? 419 LYS F N   1 
ATOM   2731 C CA  . LYS A 1 384 ? 165.98500 371.12200 24.78400  1.000 21.20612  ? 419 LYS F CA  1 
ATOM   2732 C C   . LYS A 1 384 ? 165.09400 369.99100 24.34600  1.000 18.85414  ? 419 LYS F C   1 
ATOM   2733 O O   . LYS A 1 384 ? 163.94900 370.24800 23.99000  1.000 18.96056  ? 419 LYS F O   1 
ATOM   2734 C CB  . LYS A 1 384 ? 165.84300 372.31700 23.84100  1.000 17.70332  ? 419 LYS F CB  1 
ATOM   2735 C CG  . LYS A 1 384 ? 166.86800 373.38800 24.16300  1.000 15.27911  ? 419 LYS F CG  1 
ATOM   2736 C CD  . LYS A 1 384 ? 166.50000 374.64000 23.40900  1.000 21.19478  ? 419 LYS F CD  1 
ATOM   2737 C CE  . LYS A 1 384 ? 167.55400 375.69800 23.59900  1.000 23.14638  ? 419 LYS F CE  1 
ATOM   2738 N NZ  . LYS A 1 384 ? 167.13100 376.31500 24.94700  1.000 25.89556  ? 419 LYS F NZ  1 
ATOM   2739 N N   . THR A 1 385 ? 165.56000 368.75200 24.40400  1.000 15.44255  ? 420 THR F N   1 
ATOM   2740 C CA  . THR A 1 385 ? 164.77400 367.65700 23.86700  1.000 17.82760  ? 420 THR F CA  1 
ATOM   2741 C C   . THR A 1 385 ? 163.54400 367.39900 24.71000  1.000 14.71459  ? 420 THR F C   1 
ATOM   2742 O O   . THR A 1 385 ? 163.56600 367.48700 25.93700  1.000 15.31017  ? 420 THR F O   1 
ATOM   2743 C CB  . THR A 1 385 ? 165.60400 366.37200 23.76400  1.000 17.60012  ? 420 THR F CB  1 
ATOM   2744 O OG1 . THR A 1 385 ? 166.83600 366.67400 23.10800  1.000 15.62866  ? 420 THR F OG1 1 
ATOM   2745 C CG2 . THR A 1 385 ? 164.86300 365.31100 22.95500  1.000 13.92828  ? 420 THR F CG2 1 
ATOM   2746 N N   . LYS A 1 386 ? 162.46200 367.11500 24.01200  1.000 15.70126  ? 421 LYS F N   1 
ATOM   2747 C CA  . LYS A 1 386 ? 161.15500 366.82000 24.57200  1.000 15.95138  ? 421 LYS F CA  1 
ATOM   2748 C C   . LYS A 1 386 ? 161.04200 365.30000 24.72300  1.000 15.63201  ? 421 LYS F C   1 
ATOM   2749 O O   . LYS A 1 386 ? 161.09800 364.58000 23.72900  1.000 16.77709  ? 421 LYS F O   1 
ATOM   2750 C CB  . LYS A 1 386 ? 160.05600 367.35800 23.65700  1.000 21.52119  ? 421 LYS F CB  1 
ATOM   2751 C CG  . LYS A 1 386 ? 158.67300 367.03500 24.17600  1.000 19.64366  ? 421 LYS F CG  1 
ATOM   2752 C CD  . LYS A 1 386 ? 157.52000 367.51900 23.26100  1.000 28.21300  ? 421 LYS F CD  1 
ATOM   2753 C CE  . LYS A 1 386 ? 156.19400 367.10700 23.95900  1.000 28.54211  ? 421 LYS F CE  1 
ATOM   2754 N NZ  . LYS A 1 386 ? 155.14500 366.50100 23.15400  1.000 35.50454  ? 421 LYS F NZ  1 
ATOM   2755 N N   . CYS A 1 387 ? 161.24700 364.79700 25.93800  1.000 11.70365  ? 422 CYS F N   1 
ATOM   2756 C CA  . CYS A 1 387 ? 161.13200 363.37900 26.25400  1.000 12.79826  ? 422 CYS F CA  1 
ATOM   2757 C C   . CYS A 1 387 ? 159.87000 363.04900 27.05000  1.000 17.40866  ? 422 CYS F C   1 
ATOM   2758 O O   . CYS A 1 387 ? 159.70300 363.54900 28.16200  1.000 17.53438  ? 422 CYS F O   1 
ATOM   2759 C CB  . CYS A 1 387 ? 162.37500 362.93100 27.02500  1.000 14.52984  ? 422 CYS F CB  1 
ATOM   2760 S SG  . CYS A 1 387 ? 163.88200 363.55900 26.22600  1.000 16.71037  ? 422 CYS F SG  1 
ATOM   2761 N N   . THR A 1 388 ? 159.15900 362.00300 26.64800  1.000 11.82821  ? 423 THR F N   1 
ATOM   2762 C CA  . THR A 1 388 ? 157.89800 361.69100 27.29700  1.000 14.59116  ? 423 THR F CA  1 
ATOM   2763 C C   . THR A 1 388 ? 157.62400 360.20100 27.14100  1.000 19.84562  ? 423 THR F C   1 
ATOM   2764 O O   . THR A 1 388 ? 158.23200 359.51300 26.32200  1.000 18.32177  ? 423 THR F O   1 
ATOM   2765 C CB  . THR A 1 388 ? 156.72500 362.48900 26.71600  1.000 16.05934  ? 423 THR F CB  1 
ATOM   2766 O OG1 . THR A 1 388 ? 156.54800 362.14200 25.34400  1.000 17.38801  ? 423 THR F OG1 1 
ATOM   2767 C CG2 . THR A 1 388 ? 156.96000 364.02700 26.83600  1.000 14.16236  ? 423 THR F CG2 1 
ATOM   2768 N N   . ALA A 1 389 ? 156.69800 359.72300 27.96000  1.000 19.27540  ? 424 ALA F N   1 
ATOM   2769 C CA  . ALA A 1 389 ? 156.19300 358.36000 27.96500  1.000 17.06676  ? 424 ALA F CA  1 
ATOM   2770 C C   . ALA A 1 389 ? 154.67700 358.41300 28.01100  1.000 18.70586  ? 424 ALA F C   1 
ATOM   2771 O O   . ALA A 1 389 ? 154.10900 359.20600 28.78000  1.000 18.82350  ? 424 ALA F O   1 
ATOM   2772 C CB  . ALA A 1 389 ? 156.72100 357.54100 29.15200  1.000 15.03093  ? 424 ALA F CB  1 
ATOM   2773 N N   . SER A 1 390 ? 154.05700 357.73500 27.04900  1.000 13.51562  ? 425 SER F N   1 
ATOM   2774 C CA  . SER A 1 390 ? 152.63000 357.74500 26.83000  1.000 17.37949  ? 425 SER F CA  1 
ATOM   2775 C C   . SER A 1 390 ? 151.98200 356.37000 26.88600  1.000 21.49107  ? 425 SER F C   1 
ATOM   2776 O O   . SER A 1 390 ? 152.60900 355.30700 26.70200  1.000 19.85812  ? 425 SER F O   1 
ATOM   2777 C CB  . SER A 1 390 ? 152.28000 358.37400 25.47800  1.000 15.79405  ? 425 SER F CB  1 
ATOM   2778 O OG  . SER A 1 390 ? 152.84200 359.66200 25.42900  1.000 18.44617  ? 425 SER F OG  1 
ATOM   2779 N N   . ASN A 1 391 ? 150.70300 356.45900 27.20500  1.000 21.52036  ? 426 ASN F N   1 
ATOM   2780 C CA  . ASN A 1 391 ? 149.71700 355.40000 27.13400  1.000 21.20885  ? 426 ASN F CA  1 
ATOM   2781 C C   . ASN A 1 391 ? 148.81000 355.71000 25.96000  1.000 20.44628  ? 426 ASN F C   1 
ATOM   2782 O O   . ASN A 1 391 ? 148.39500 356.86100 25.78700  1.000 21.65431  ? 426 ASN F O   1 
ATOM   2783 C CB  . ASN A 1 391 ? 148.89500 355.36900 28.41900  1.000 19.71642  ? 426 ASN F CB  1 
ATOM   2784 C CG  . ASN A 1 391 ? 147.85900 354.27100 28.41700  1.000 29.22254  ? 426 ASN F CG  1 
ATOM   2785 O OD1 . ASN A 1 391 ? 146.75500 354.51400 27.92000  1.000 26.74818  ? 426 ASN F OD1 1 
ATOM   2786 N ND2 . ASN A 1 391 ? 148.15100 353.11400 29.01600  1.000 25.27694  ? 426 ASN F ND2 1 
ATOM   2787 N N   . LYS A 1 392 ? 148.38300 354.67100 25.25200  1.000 23.34054  ? 427 LYS F N   1 
ATOM   2788 C CA  . LYS A 1 392 ? 147.65100 354.88100 23.99800  1.000 29.40465  ? 427 LYS F CA  1 
ATOM   2789 C C   . LYS A 1 392 ? 146.35100 355.65200 24.20400  1.000 23.64987  ? 427 LYS F C   1 
ATOM   2790 O O   . LYS A 1 392 ? 145.96900 356.46400 23.35900  1.000 27.67743  ? 427 LYS F O   1 
ATOM   2791 C CB  . LYS A 1 392 ? 147.35500 353.54400 23.32800  1.000 31.64793  ? 427 LYS F CB  1 
ATOM   2792 C CG  . LYS A 1 392 ? 146.87800 353.66900 21.89000  1.000 33.30589  ? 427 LYS F CG  1 
ATOM   2793 C CD  . LYS A 1 392 ? 146.34900 352.30800 21.42600  1.000 40.43740  ? 427 LYS F CD  1 
ATOM   2794 C CE  . LYS A 1 392 ? 145.20700 352.43700 20.42800  1.000 43.40987  ? 427 LYS F CE  1 
ATOM   2795 N NZ  . LYS A 1 392 ? 145.59300 351.82100 19.11500  1.000 48.84691  ? 427 LYS F NZ  1 
ATOM   2796 N N   . ASN A 1 393 ? 145.67100 355.43400 25.32800  1.000 24.72175  ? 428 ASN F N   1 
ATOM   2797 C CA  . ASN A 1 393 ? 144.38400 356.07300 25.56100  1.000 28.70755  ? 428 ASN F CA  1 
ATOM   2798 C C   . ASN A 1 393 ? 144.41000 357.21200 26.55600  1.000 27.08255  ? 428 ASN F C   1 
ATOM   2799 O O   . ASN A 1 393 ? 143.52900 358.06400 26.49700  1.000 30.13283  ? 428 ASN F O   1 
ATOM   2800 C CB  . ASN A 1 393 ? 143.32500 355.06800 26.05300  1.000 27.98585  ? 428 ASN F CB  1 
ATOM   2801 C CG  . ASN A 1 393 ? 143.21400 353.85000 25.16100  1.000 36.04901  ? 428 ASN F CG  1 
ATOM   2802 O OD1 . ASN A 1 393 ? 142.55800 353.92500 24.13400  1.000 41.46236  ? 428 ASN F OD1 1 
ATOM   2803 N ND2 . ASN A 1 393 ? 143.69200 352.70300 25.61900  1.000 33.58228  ? 428 ASN F ND2 1 
ATOM   2804 N N   . ARG A 1 394 ? 145.41200 357.27700 27.42200  1.000 25.37406  ? 429 ARG F N   1 
ATOM   2805 C CA  . ARG A 1 394 ? 145.50400 358.36100 28.38500  1.000 27.88890  ? 429 ARG F CA  1 
ATOM   2806 C C   . ARG A 1 394 ? 146.37100 359.51500 27.89700  1.000 23.85596  ? 429 ARG F C   1 
ATOM   2807 O O   . ARG A 1 394 ? 146.24800 360.62100 28.42500  1.000 34.37700  ? 429 ARG F O   1 
ATOM   2808 C CB  . ARG A 1 394 ? 145.99400 357.82200 29.73500  1.000 27.19700  ? 429 ARG F CB  1 
ATOM   2809 C CG  . ARG A 1 394 ? 145.36600 356.48000 30.06600  1.000 30.45745  ? 429 ARG F CG  1 
ATOM   2810 C CD  . ARG A 1 394 ? 145.72300 355.93300 31.43700  1.000 34.82158  ? 429 ARG F CD  1 
ATOM   2811 N NE  . ARG A 1 394 ? 144.98100 354.69800 31.68800  1.000 41.95207  ? 429 ARG F NE  1 
ATOM   2812 C CZ  . ARG A 1 394 ? 145.54800 353.52600 31.94100  1.000 38.07093  ? 429 ARG F CZ  1 
ATOM   2813 N NH1 . ARG A 1 394 ? 146.84800 353.42200 32.17600  1.000 37.80715  ? 429 ARG F NH1 1 
ATOM   2814 N NH2 . ARG A 1 394 ? 144.78700 352.43600 32.00000  1.000 48.21063  ? 429 ARG F NH2 1 
ATOM   2815 N N   . GLY A 1 395 ? 147.27000 359.28100 26.95500  1.000 23.09606  ? 430 GLY F N   1 
ATOM   2816 C CA  . GLY A 1 395 ? 148.15800 360.33000 26.48900  1.000 20.41694  ? 430 GLY F CA  1 
ATOM   2817 C C   . GLY A 1 395 ? 149.47200 360.33500 27.24100  1.000 18.85425  ? 430 GLY F C   1 
ATOM   2818 O O   . GLY A 1 395 ? 149.90800 359.30700 27.76200  1.000 19.56676  ? 430 GLY F O   1 
ATOM   2819 N N   . ILE A 1 396 ? 150.09400 361.50300 27.32300  1.000 18.56692  ? 431 ILE F N   1 
ATOM   2820 C CA  . ILE A 1 396 ? 151.37400 361.63200 27.99900  1.000 15.62428  ? 431 ILE F CA  1 
ATOM   2821 C C   . ILE A 1 396 ? 151.17600 361.43300 29.48900  1.000 18.22219  ? 431 ILE F C   1 
ATOM   2822 O O   . ILE A 1 396 ? 150.41800 362.17000 30.13300  1.000 21.76080  ? 431 ILE F O   1 
ATOM   2823 C CB  . ILE A 1 396 ? 151.99600 363.00200 27.71700  1.000 12.92462  ? 431 ILE F CB  1 
ATOM   2824 C CG1 . ILE A 1 396 ? 152.40900 363.08200 26.25100  1.000 18.54181  ? 431 ILE F CG1 1 
ATOM   2825 C CG2 . ILE A 1 396 ? 153.15000 363.18700 28.67200  1.000 15.55869  ? 431 ILE F CG2 1 
ATOM   2826 C CD1 . ILE A 1 396 ? 152.92500 364.45600 25.81900  1.000 18.83978  ? 431 ILE F CD1 1 
ATOM   2827 N N   . ILE A 1 397 ? 151.81200 360.40600 30.03900  1.000 17.64947  ? 432 ILE F N   1 
ATOM   2828 C CA  . ILE A 1 397 ? 151.73400 360.12300 31.46900  1.000 19.76518  ? 432 ILE F CA  1 
ATOM   2829 C C   . ILE A 1 397 ? 153.02900 360.41000 32.21400  1.000 21.69975  ? 432 ILE F C   1 
ATOM   2830 O O   . ILE A 1 397 ? 153.01700 360.45200 33.45400  1.000 15.60034  ? 432 ILE F O   1 
ATOM   2831 C CB  . ILE A 1 397 ? 151.20500 358.70200 31.75700  1.000 27.04155  ? 432 ILE F CB  1 
ATOM   2832 C CG1 . ILE A 1 397 ? 152.04800 357.63200 31.08400  1.000 23.03614  ? 432 ILE F CG1 1 
ATOM   2833 C CG2 . ILE A 1 397 ? 149.75600 358.61000 31.26400  1.000 18.95114  ? 432 ILE F CG2 1 
ATOM   2834 C CD1 . ILE A 1 397 ? 153.02100 357.04100 32.03100  1.000 35.93782  ? 432 ILE F CD1 1 
ATOM   2835 N N   . LYS A 1 398 ? 154.13500 360.63900 31.51200  1.000 21.11879  ? 433 LYS F N   1 
ATOM   2836 C CA  . LYS A 1 398 ? 155.39300 360.97300 32.17600  1.000 17.07107  ? 433 LYS F CA  1 
ATOM   2837 C C   . LYS A 1 398 ? 156.28200 361.80600 31.27800  1.000 15.11345  ? 433 LYS F C   1 
ATOM   2838 O O   . LYS A 1 398 ? 156.28900 361.60800 30.06600  1.000 18.08306  ? 433 LYS F O   1 
ATOM   2839 C CB  . LYS A 1 398 ? 156.18700 359.71000 32.56000  1.000 17.58758  ? 433 LYS F CB  1 
ATOM   2840 C CG  . LYS A 1 398 ? 157.52100 360.02100 33.21800  1.000 19.49953  ? 433 LYS F CG  1 
ATOM   2841 C CD  . LYS A 1 398 ? 158.19400 358.80500 33.83600  1.000 29.33946  ? 433 LYS F CD  1 
ATOM   2842 C CE  . LYS A 1 398 ? 159.44500 359.20000 34.60800  1.000 27.80105  ? 433 LYS F CE  1 
ATOM   2843 N NZ  . LYS A 1 398 ? 159.21200 359.55800 36.03200  1.000 39.12886  ? 433 LYS F NZ  1 
ATOM   2844 N N   . THR A 1 399 ? 156.81900 362.86600 31.85100  1.000 19.08175  ? 434 THR F N   1 
ATOM   2845 C CA  . THR A 1 399 ? 157.80500 363.73800 31.23200  1.000 16.50758  ? 434 THR F CA  1 
ATOM   2846 C C   . THR A 1 399 ? 159.14900 363.58200 31.93200  1.000 23.01982  ? 434 THR F C   1 
ATOM   2847 O O   . THR A 1 399 ? 159.24200 363.74200 33.16100  1.000 19.15705  ? 434 THR F O   1 
ATOM   2848 C CB  . THR A 1 399 ? 157.34000 365.18800 31.28400  1.000 16.11743  ? 434 THR F CB  1 
ATOM   2849 O OG1 . THR A 1 399 ? 156.04600 365.27800 30.66800  1.000 16.36532  ? 434 THR F OG1 1 
ATOM   2850 C CG2 . THR A 1 399 ? 158.32000 366.08700 30.54500  1.000 16.80797  ? 434 THR F CG2 1 
ATOM   2851 N N   . PHE A 1 400 ? 160.17500 363.20700 31.17000  1.000 17.72155  ? 435 PHE F N   1 
ATOM   2852 C CA  . PHE A 1 400 ? 161.50000 363.00300 31.74500  1.000 22.01351  ? 435 PHE F CA  1 
ATOM   2853 C C   . PHE A 1 400 ? 162.19400 364.35900 31.93900  1.000 22.43793  ? 435 PHE F C   1 
ATOM   2854 O O   . PHE A 1 400 ? 162.10300 365.24300 31.07600  1.000 29.28824  ? 435 PHE F O   1 
ATOM   2855 C CB  . PHE A 1 400 ? 162.33200 362.10700 30.82600  1.000 20.58171  ? 435 PHE F CB  1 
ATOM   2856 C CG  . PHE A 1 400 ? 161.73200 360.74200 30.56200  1.000 21.68338  ? 435 PHE F CG  1 
ATOM   2857 C CD1 . PHE A 1 400 ? 161.94800 359.69900 31.43900  1.000 19.98249  ? 435 PHE F CD1 1 
ATOM   2858 C CD2 . PHE A 1 400 ? 160.95200 360.50800 29.44200  1.000 16.99354  ? 435 PHE F CD2 1 
ATOM   2859 C CE1 . PHE A 1 400 ? 161.42400 358.45500 31.18700  1.000 22.05086  ? 435 PHE F CE1 1 
ATOM   2860 C CE2 . PHE A 1 400 ? 160.41900 359.27500 29.18900  1.000 20.63530  ? 435 PHE F CE2 1 
ATOM   2861 C CZ  . PHE A 1 400 ? 160.65800 358.23500 30.05800  1.000 24.02502  ? 435 PHE F CZ  1 
ATOM   2862 N N   . SER A 1 401 ? 162.92400 364.53300 33.05300  1.000 31.13810  ? 436 SER F N   1 
ATOM   2863 C CA  . SER A 1 401 ? 163.69100 365.77800 33.13400  1.000 28.17089  ? 436 SER F CA  1 
ATOM   2864 C C   . SER A 1 401 ? 165.07700 365.49700 32.56700  1.000 24.57358  ? 436 SER F C   1 
ATOM   2865 O O   . SER A 1 401 ? 165.42600 364.34500 32.30000  1.000 27.26901  ? 436 SER F O   1 
ATOM   2866 C CB  . SER A 1 401 ? 163.80400 366.31400 34.57900  1.000 32.11349  ? 436 SER F CB  1 
ATOM   2867 O OG  . SER A 1 401 ? 162.53200 366.56700 35.20600  1.000 38.35209  ? 436 SER F OG  1 
ATOM   2868 N N   . ASN A 1 402 ? 165.92800 366.52300 32.57300  1.000 22.03583  ? 437 ASN F N   1 
ATOM   2869 C CA  . ASN A 1 402 ? 167.27000 366.40800 32.03400  1.000 31.82749  ? 437 ASN F CA  1 
ATOM   2870 C C   . ASN A 1 402 ? 168.05800 365.47200 32.91400  1.000 25.24194  ? 437 ASN F C   1 
ATOM   2871 O O   . ASN A 1 402 ? 167.90600 365.49400 34.13100  1.000 20.19922  ? 437 ASN F O   1 
ATOM   2872 C CB  . ASN A 1 402 ? 167.96300 367.77100 31.88400  1.000 25.32649  ? 437 ASN F CB  1 
ATOM   2873 C CG  . ASN A 1 402 ? 167.64700 368.39700 30.54800  1.000 36.46737  ? 437 ASN F CG  1 
ATOM   2874 O OD1 . ASN A 1 402 ? 166.76600 367.91400 29.83400  1.000 39.77054  ? 437 ASN F OD1 1 
ATOM   2875 N ND2 . ASN A 1 402 ? 168.39400 369.43100 30.16100  1.000 46.04135  ? 437 ASN F ND2 1 
ATOM   2876 N N   . GLY A 1 403 ? 168.71500 364.51800 32.28900  1.000 21.03775  ? 438 GLY F N   1 
ATOM   2877 C CA  . GLY A 1 403 ? 169.44100 363.52200 33.01600  1.000 21.06119  ? 438 GLY F CA  1 
ATOM   2878 C C   . GLY A 1 403 ? 169.03900 362.19300 32.47200  1.000 19.24852  ? 438 GLY F C   1 
ATOM   2879 O O   . GLY A 1 403 ? 168.45200 362.08500 31.38600  1.000 17.33533  ? 438 GLY F O   1 
ATOM   2880 N N   . CYS A 1 404 ? 169.38100 361.15500 33.20400  1.000 16.17264  ? 439 CYS F N   1 
ATOM   2881 C CA  . CYS A 1 404 ? 169.04400 359.81700 32.78200  1.000 17.40106  ? 439 CYS F CA  1 
ATOM   2882 C C   . CYS A 1 404 ? 167.94600 359.32700 33.70300  1.000 18.62723  ? 439 CYS F C   1 
ATOM   2883 O O   . CYS A 1 404 ? 168.09300 359.38900 34.92400  1.000 17.83369  ? 439 CYS F O   1 
ATOM   2884 C CB  . CYS A 1 404 ? 170.28500 358.92700 32.83800  1.000 16.59580  ? 439 CYS F CB  1 
ATOM   2885 S SG  . CYS A 1 404 ? 169.90700 357.21200 32.47200  1.000 22.03395  ? 439 CYS F SG  1 
ATOM   2886 N N   . ASP A 1 405 ? 166.87100 358.80300 33.11800  1.000 18.56070  ? 440 ASP F N   1 
ATOM   2887 C CA  . ASP A 1 405 ? 165.73500 358.33800 33.88200  1.000 17.56791  ? 440 ASP F CA  1 
ATOM   2888 C C   . ASP A 1 405 ? 165.23100 357.04800 33.25400  1.000 17.50230  ? 440 ASP F C   1 
ATOM   2889 O O   . ASP A 1 405 ? 165.72100 356.60800 32.20700  1.000 18.08042  ? 440 ASP F O   1 
ATOM   2890 C CB  . ASP A 1 405 ? 164.61500 359.38500 33.84900  1.000 20.97458  ? 440 ASP F CB  1 
ATOM   2891 C CG  . ASP A 1 405 ? 163.71300 359.36800 35.09300  1.000 22.04580  ? 440 ASP F CG  1 
ATOM   2892 O OD1 . ASP A 1 405 ? 163.69900 358.39300 35.87800  1.000 20.24518  ? 440 ASP F OD1 1 
ATOM   2893 O OD2 . ASP A 1 405 ? 162.87100 360.28200 35.17500  1.000 26.80920  ? 440 ASP F OD2 1 
ATOM   2894 N N   . TYR A 1 406 ? 164.16200 356.51300 33.83400  1.000 13.94967  ? 441 TYR F N   1 
ATOM   2895 C CA  . TYR A 1 406 ? 163.61100 355.23200 33.42300  1.000 17.39730  ? 441 TYR F CA  1 
ATOM   2896 C C   . TYR A 1 406 ? 162.11500 355.12300 33.68900  1.000 20.36596  ? 441 TYR F C   1 
ATOM   2897 O O   . TYR A 1 406 ? 161.58500 355.78400 34.59200  1.000 17.66800  ? 441 TYR F O   1 
ATOM   2898 C CB  . TYR A 1 406 ? 164.33200 354.13600 34.22600  1.000 16.72877  ? 441 TYR F CB  1 
ATOM   2899 C CG  . TYR A 1 406 ? 163.78300 352.74000 34.09000  1.000 16.11105  ? 441 TYR F CG  1 
ATOM   2900 C CD1 . TYR A 1 406 ? 164.18600 351.89500 33.05400  1.000 17.58751  ? 441 TYR F CD1 1 
ATOM   2901 C CD2 . TYR A 1 406 ? 162.85200 352.26100 35.00000  1.000 19.01155  ? 441 TYR F CD2 1 
ATOM   2902 C CE1 . TYR A 1 406 ? 163.67700 350.59500 32.95000  1.000 18.97578  ? 441 TYR F CE1 1 
ATOM   2903 C CE2 . TYR A 1 406 ? 162.33700 350.97500 34.89800  1.000 21.32206  ? 441 TYR F CE2 1 
ATOM   2904 C CZ  . TYR A 1 406 ? 162.76000 350.14500 33.87400  1.000 19.39878  ? 441 TYR F CZ  1 
ATOM   2905 O OH  . TYR A 1 406 ? 162.24400 348.87000 33.78000  1.000 20.43659  ? 441 TYR F OH  1 
ATOM   2906 N N   . VAL A 1 407 ? 161.41700 354.34400 32.86700  1.000 16.30068  ? 442 VAL F N   1 
ATOM   2907 C CA  . VAL A 1 407 ? 159.99400 354.10600 33.14400  1.000 16.73345  ? 442 VAL F CA  1 
ATOM   2908 C C   . VAL A 1 407 ? 159.71400 352.63900 32.82600  1.000 19.03724  ? 442 VAL F C   1 
ATOM   2909 O O   . VAL A 1 407 ? 160.27200 352.09600 31.86200  1.000 16.44986  ? 442 VAL F O   1 
ATOM   2910 C CB  . VAL A 1 407 ? 159.01200 354.98700 32.35200  1.000 19.17975  ? 442 VAL F CB  1 
ATOM   2911 C CG1 . VAL A 1 407 ? 159.08500 354.66400 30.87700  1.000 16.27334  ? 442 VAL F CG1 1 
ATOM   2912 C CG2 . VAL A 1 407 ? 157.61000 354.81900 32.89600  1.000 23.52501  ? 442 VAL F CG2 1 
ATOM   2913 N N   . SER A 1 408 ? 158.87600 351.98900 33.63800  1.000 19.22885  ? 443 SER F N   1 
ATOM   2914 C CA  . SER A 1 408 ? 158.47200 350.59500 33.42100  1.000 24.54293  ? 443 SER F CA  1 
ATOM   2915 C C   . SER A 1 408 ? 157.38500 350.55300 32.35200  1.000 23.03478  ? 443 SER F C   1 
ATOM   2916 O O   . SER A 1 408 ? 156.77300 351.56600 32.02000  1.000 22.61760  ? 443 SER F O   1 
ATOM   2917 C CB  . SER A 1 408 ? 157.97400 349.87300 34.67900  1.000 24.10302  ? 443 SER F CB  1 
ATOM   2918 O OG  . SER A 1 408 ? 156.79700 350.42400 35.18900  1.000 26.99782  ? 443 SER F OG  1 
ATOM   2919 N N   . ASN A 1 409 ? 157.12600 349.36200 31.83300  1.000 20.58490  ? 444 ASN F N   1 
ATOM   2920 C CA  . ASN A 1 409 ? 156.08200 349.16400 30.83300  1.000 24.39921  ? 444 ASN F CA  1 
ATOM   2921 C C   . ASN A 1 409 ? 154.68500 349.09800 31.46100  1.000 24.89995  ? 444 ASN F C   1 
ATOM   2922 O O   . ASN A 1 409 ? 153.71700 348.87500 30.73200  1.000 24.05148  ? 444 ASN F O   1 
ATOM   2923 C CB  . ASN A 1 409 ? 156.29200 347.89300 29.99000  1.000 21.84105  ? 444 ASN F CB  1 
ATOM   2924 C CG  . ASN A 1 409 ? 156.32000 346.60100 30.82400  1.000 29.00940  ? 444 ASN F CG  1 
ATOM   2925 O OD1 . ASN A 1 409 ? 156.22200 346.63200 32.04400  1.000 23.76162  ? 444 ASN F OD1 1 
ATOM   2926 N ND2 . ASN A 1 409 ? 156.46000 345.45800 30.14300  1.000 20.23819  ? 444 ASN F ND2 1 
ATOM   2927 N N   . LYS A 1 410 ? 154.55200 349.16000 32.78900  1.000 24.59672  ? 445 LYS F N   1 
ATOM   2928 C CA  . LYS A 1 410 ? 153.22700 349.07400 33.42400  1.000 25.46370  ? 445 LYS F CA  1 
ATOM   2929 C C   . LYS A 1 410 ? 152.44500 350.36600 33.17400  1.000 25.59504  ? 445 LYS F C   1 
ATOM   2930 O O   . LYS A 1 410 ? 152.76500 351.42900 33.69700  1.000 24.78367  ? 445 LYS F O   1 
ATOM   2931 C CB  . LYS A 1 410 ? 153.39000 348.79200 34.91300  1.000 27.37641  ? 445 LYS F CB  1 
ATOM   2932 C CG  . LYS A 1 410 ? 154.06200 347.42400 34.99400  1.000 42.28796  ? 445 LYS F CG  1 
ATOM   2933 C CD  . LYS A 1 410 ? 153.18000 346.27000 35.41400  1.000 47.21407  ? 445 LYS F CD  1 
ATOM   2934 C CE  . LYS A 1 410 ? 154.04200 344.99300 35.19900  1.000 49.78501  ? 445 LYS F CE  1 
ATOM   2935 N NZ  . LYS A 1 410 ? 153.40800 343.68400 35.51300  1.000 56.16825  ? 445 LYS F NZ  1 
ATOM   2936 N N   . GLY A 1 411 ? 151.52900 350.32600 32.22000  1.000 29.51371  ? 446 GLY F N   1 
ATOM   2937 C CA  . GLY A 1 411 ? 150.73700 351.49100 31.90100  1.000 25.70589  ? 446 GLY F CA  1 
ATOM   2938 C C   . GLY A 1 411 ? 151.30600 352.32900 30.77700  1.000 31.53321  ? 446 GLY F C   1 
ATOM   2939 O O   . GLY A 1 411 ? 150.65000 353.28800 30.35300  1.000 28.20148  ? 446 GLY F O   1 
ATOM   2940 N N   . VAL A 1 412 ? 152.52500 352.01600 30.32300  1.000 23.89763  ? 447 VAL F N   1 
ATOM   2941 C CA  . VAL A 1 412 ? 153.23200 352.73500 29.27000  1.000 21.35609  ? 447 VAL F CA  1 
ATOM   2942 C C   . VAL A 1 412 ? 153.24300 351.89800 28.00600  1.000 24.73687  ? 447 VAL F C   1 
ATOM   2943 O O   . VAL A 1 412 ? 153.64900 350.72800 28.02900  1.000 23.97611  ? 447 VAL F O   1 
ATOM   2944 C CB  . VAL A 1 412 ? 154.67000 353.08400 29.70300  1.000 23.41220  ? 447 VAL F CB  1 
ATOM   2945 C CG1 . VAL A 1 412 ? 155.46300 353.74500 28.55500  1.000 17.82503  ? 447 VAL F CG1 1 
ATOM   2946 C CG2 . VAL A 1 412 ? 154.60700 354.05400 30.86400  1.000 22.03086  ? 447 VAL F CG2 1 
ATOM   2947 N N   . ASP A 1 413 ? 152.92400 352.53600 26.89100  1.000 16.92665  ? 448 ASP F N   1 
ATOM   2948 C CA  . ASP A 1 413 ? 152.93700 351.90700 25.58400  1.000 18.73897  ? 448 ASP F CA  1 
ATOM   2949 C C   . ASP A 1 413 ? 154.10100 352.39300 24.73500  1.000 22.48406  ? 448 ASP F C   1 
ATOM   2950 O O   . ASP A 1 413 ? 154.71500 351.59700 24.01000  1.000 21.29115  ? 448 ASP F O   1 
ATOM   2951 C CB  . ASP A 1 413 ? 151.61800 352.18200 24.85000  1.000 16.59089  ? 448 ASP F CB  1 
ATOM   2952 C CG  . ASP A 1 413 ? 150.42500 351.52800 25.53100  1.000 32.22569  ? 448 ASP F CG  1 
ATOM   2953 O OD1 . ASP A 1 413 ? 150.57900 350.43300 26.12900  1.000 34.69767  ? 448 ASP F OD1 1 
ATOM   2954 O OD2 . ASP A 1 413 ? 149.34300 352.14000 25.51000  1.000 29.23841  ? 448 ASP F OD2 1 
ATOM   2955 N N   . THR A 1 414 ? 154.32900 353.70600 24.70700  1.000 22.03562  ? 449 THR F N   1 
ATOM   2956 C CA  . THR A 1 414 ? 155.38300 354.29200 23.89100  1.000 16.29912  ? 449 THR F CA  1 
ATOM   2957 C C   . THR A 1 414 ? 156.19600 355.30400 24.68100  1.000 20.14913  ? 449 THR F C   1 
ATOM   2958 O O   . THR A 1 414 ? 155.78100 355.79200 25.73600  1.000 16.57014  ? 449 THR F O   1 
ATOM   2959 C CB  . THR A 1 414 ? 154.83500 354.93800 22.62100  1.000 19.85997  ? 449 THR F CB  1 
ATOM   2960 O OG1 . THR A 1 414 ? 153.92600 355.97300 22.98800  1.000 20.10572  ? 449 THR F OG1 1 
ATOM   2961 C CG2 . THR A 1 414 ? 154.07100 353.87700 21.77600  1.000 14.55280  ? 449 THR F CG2 1 
ATOM   2962 N N   . VAL A 1 415 ? 157.37200 355.58300 24.13800  1.000 15.41505  ? 450 VAL F N   1 
ATOM   2963 C CA  . VAL A 1 415 ? 158.29700 356.59200 24.62900  1.000 18.90467  ? 450 VAL F CA  1 
ATOM   2964 C C   . VAL A 1 415 ? 158.74500 357.45600 23.45300  1.000 20.40416  ? 450 VAL F C   1 
ATOM   2965 O O   . VAL A 1 415 ? 159.00600 356.93800 22.36500  1.000 17.22817  ? 450 VAL F O   1 
ATOM   2966 C CB  . VAL A 1 415 ? 159.51000 355.97100 25.33800  1.000 20.54263  ? 450 VAL F CB  1 
ATOM   2967 C CG1 . VAL A 1 415 ? 160.56900 356.98600 25.48300  1.000 27.04104  ? 450 VAL F CG1 1 
ATOM   2968 C CG2 . VAL A 1 415 ? 159.10300 355.51700 26.75300  1.000 15.85728  ? 450 VAL F CG2 1 
ATOM   2969 N N   . SER A 1 416 ? 158.61700 358.76500 23.59200  1.000 13.23841  ? 451 SER F N   1 
ATOM   2970 C CA  . SER A 1 416 ? 159.00900 359.69600 22.54300  1.000 15.99142  ? 451 SER F CA  1 
ATOM   2971 C C   . SER A 1 416 ? 160.22100 360.50400 22.99900  1.000 15.14154  ? 451 SER F C   1 
ATOM   2972 O O   . SER A 1 416 ? 160.24200 361.03800 24.10800  1.000 18.37297  ? 451 SER F O   1 
ATOM   2973 C CB  . SER A 1 416 ? 157.86500 360.60600 22.12100  1.000 16.35964  ? 451 SER F CB  1 
ATOM   2974 O OG  . SER A 1 416 ? 156.87200 359.78400 21.52200  1.000 25.14809  ? 451 SER F OG  1 
ATOM   2975 N N   . VAL A 1 417 ? 161.24100 360.56100 22.15400  1.000 15.33222  ? 452 VAL F N   1 
ATOM   2976 C CA  . VAL A 1 417 ? 162.44000 361.34800 22.39500  1.000 14.45473  ? 452 VAL F CA  1 
ATOM   2977 C C   . VAL A 1 417 ? 162.67500 362.23300 21.17000  1.000 13.88059  ? 452 VAL F C   1 
ATOM   2978 O O   . VAL A 1 417 ? 162.92600 361.72100 20.06700  1.000 18.37943  ? 452 VAL F O   1 
ATOM   2979 C CB  . VAL A 1 417 ? 163.65500 360.44700 22.66500  1.000 20.36298  ? 452 VAL F CB  1 
ATOM   2980 C CG1 . VAL A 1 417 ? 164.95400 361.29800 22.73500  1.000 14.11094  ? 452 VAL F CG1 1 
ATOM   2981 C CG2 . VAL A 1 417 ? 163.42700 359.63800 23.95300  1.000 15.24120  ? 452 VAL F CG2 1 
ATOM   2982 N N   . GLY A 1 418 ? 162.45700 363.53500 21.31800  1.000 14.56213  ? 453 GLY F N   1 
ATOM   2983 C CA  . GLY A 1 418 ? 162.58100 364.39800 20.13900  1.000 11.93053  ? 453 GLY F CA  1 
ATOM   2984 C C   . GLY A 1 418 ? 161.50000 364.05400 19.12900  1.000 15.44386  ? 453 GLY F C   1 
ATOM   2985 O O   . GLY A 1 418 ? 160.35200 363.82800 19.50100  1.000 14.26719  ? 453 GLY F O   1 
ATOM   2986 N N   . ASN A 1 419 ? 161.89100 363.81900 17.87100  1.000 13.93637  ? 454 ASN F N   1 
ATOM   2987 C CA  . ASN A 1 419 ? 160.94600 363.43300 16.83100  1.000 16.18716  ? 454 ASN F CA  1 
ATOM   2988 C C   . ASN A 1 419 ? 160.83000 361.92200 16.65200  1.000 18.92039  ? 454 ASN F C   1 
ATOM   2989 O O   . ASN A 1 419 ? 160.34400 361.46800 15.61200  1.000 26.33722  ? 454 ASN F O   1 
ATOM   2990 C CB  . ASN A 1 419 ? 161.39700 364.03900 15.49500  1.000 16.23774  ? 454 ASN F CB  1 
ATOM   2991 C CG  . ASN A 1 419 ? 161.43700 365.57100 15.52800  1.000 19.62770  ? 454 ASN F CG  1 
ATOM   2992 O OD1 . ASN A 1 419 ? 160.68100 366.17200 16.27400  1.000 18.84854  ? 454 ASN F OD1 1 
ATOM   2993 N ND2 . ASN A 1 419 ? 162.39200 366.18800 14.80900  1.000 14.56874  ? 454 ASN F ND2 1 
ATOM   2994 N N   . THR A 1 420 ? 161.30300 361.13600 17.61100  1.000 16.47173  ? 455 THR F N   1 
ATOM   2995 C CA  . THR A 1 420 ? 161.27300 359.68300 17.50700  1.000 17.87792  ? 455 THR F CA  1 
ATOM   2996 C C   . THR A 1 420 ? 160.38500 359.01200 18.54700  1.000 19.40863  ? 455 THR F C   1 
ATOM   2997 O O   . THR A 1 420 ? 160.58300 359.21900 19.75100  1.000 18.32285  ? 455 THR F O   1 
ATOM   2998 C CB  . THR A 1 420 ? 162.68200 359.13300 17.60800  1.000 21.48557  ? 455 THR F CB  1 
ATOM   2999 O OG1 . THR A 1 420 ? 163.45800 359.74100 16.57200  1.000 26.85572  ? 455 THR F OG1 1 
ATOM   3000 C CG2 . THR A 1 420 ? 162.64800 357.64000 17.33400  1.000 23.12976  ? 455 THR F CG2 1 
ATOM   3001 N N   . LEU A 1 421 ? 159.56800 358.06300 18.10300  1.000 14.84341  ? 456 LEU F N   1 
ATOM   3002 C CA  . LEU A 1 421 ? 158.66600 357.30700 18.96200  1.000 14.97396  ? 456 LEU F CA  1 
ATOM   3003 C C   . LEU A 1 421 ? 159.07200 355.83500 18.94300  1.000 23.70275  ? 456 LEU F C   1 
ATOM   3004 O O   . LEU A 1 421 ? 159.35200 355.29600 17.86600  1.000 18.85131  ? 456 LEU F O   1 
ATOM   3005 C CB  . LEU A 1 421 ? 157.22900 357.38100 18.45300  1.000 13.92837  ? 456 LEU F CB  1 
ATOM   3006 C CG  . LEU A 1 421 ? 156.21000 356.66200 19.34700  1.000 22.00382  ? 456 LEU F CG  1 
ATOM   3007 C CD1 . LEU A 1 421 ? 154.91700 357.46200 19.49500  1.000 15.65175  ? 456 LEU F CD1 1 
ATOM   3008 C CD2 . LEU A 1 421 ? 155.95400 355.25000 18.80900  1.000 19.80880  ? 456 LEU F CD2 1 
ATOM   3009 N N   . TYR A 1 422 ? 159.35800 355.28300 20.12500  1.000 15.38686  ? 457 TYR F N   1 
ATOM   3010 C CA  . TYR A 1 422 ? 159.66200 353.88000 20.33800  1.000 17.83189  ? 457 TYR F CA  1 
ATOM   3011 C C   . TYR A 1 422 ? 158.48400 353.18300 21.00700  1.000 20.79128  ? 457 TYR F C   1 
ATOM   3012 O O   . TYR A 1 422 ? 157.90900 353.72800 21.95800  1.000 15.49699  ? 457 TYR F O   1 
ATOM   3013 C CB  . TYR A 1 422 ? 160.91100 353.71000 21.20000  1.000 21.59347  ? 457 TYR F CB  1 
ATOM   3014 C CG  . TYR A 1 422 ? 162.06400 354.50000 20.65400  1.000 20.88902  ? 457 TYR F CG  1 
ATOM   3015 C CD1 . TYR A 1 422 ? 162.24500 355.82900 21.04000  1.000 26.31817  ? 457 TYR F CD1 1 
ATOM   3016 C CD2 . TYR A 1 422 ? 162.87600 353.98000 19.63300  1.000 22.61122  ? 457 TYR F CD2 1 
ATOM   3017 C CE1 . TYR A 1 422 ? 163.28000 356.60300 20.51200  1.000 30.39894  ? 457 TYR F CE1 1 
ATOM   3018 C CE2 . TYR A 1 422 ? 163.92500 354.74200 19.08100  1.000 25.65615  ? 457 TYR F CE2 1 
ATOM   3019 C CZ  . TYR A 1 422 ? 164.11900 356.05500 19.53300  1.000 30.94679  ? 457 TYR F CZ  1 
ATOM   3020 O OH  . TYR A 1 422 ? 165.13300 356.84000 19.02300  1.000 41.49873  ? 457 TYR F OH  1 
ATOM   3021 N N   . CYS A 1 423 ? 158.37900 351.88300 20.78100  1.000 16.48155  ? 458 CYS F N   1 
ATOM   3022 C CA  . CYS A 1 423 ? 157.35800 351.04300 21.40700  1.000 18.25005  ? 458 CYS F CA  1 
ATOM   3023 C C   . CYS A 1 423 ? 158.02400 350.27300 22.53000  1.000 19.79890  ? 458 CYS F C   1 
ATOM   3024 O O   . CYS A 1 423 ? 159.12700 349.76400 22.36200  1.000 20.22513  ? 458 CYS F O   1 
ATOM   3025 C CB  . CYS A 1 423 ? 156.79600 349.96500 20.45400  1.000 18.75818  ? 458 CYS F CB  1 
ATOM   3026 S SG  . CYS A 1 423 ? 155.80800 350.44900 18.99800  1.000 30.75501  ? 458 CYS F SG  1 
ATOM   3027 N N   . VAL A 1 424 ? 157.37000 350.21600 23.66700  1.000 18.28811  ? 459 VAL F N   1 
ATOM   3028 C CA  . VAL A 1 424 ? 157.85100 349.53300 24.86200  1.000 21.14807  ? 459 VAL F CA  1 
ATOM   3029 C C   . VAL A 1 424 ? 157.37600 348.08300 24.82200  1.000 26.12979  ? 459 VAL F C   1 
ATOM   3030 O O   . VAL A 1 424 ? 156.23200 347.80500 24.43600  1.000 22.63864  ? 459 VAL F O   1 
ATOM   3031 C CB  . VAL A 1 424 ? 157.37400 350.23300 26.14300  1.000 23.32429  ? 459 VAL F CB  1 
ATOM   3032 C CG1 . VAL A 1 424 ? 157.96500 349.53500 27.32700  1.000 23.97184  ? 459 VAL F CG1 1 
ATOM   3033 C CG2 . VAL A 1 424 ? 157.86300 351.69300 26.13900  1.000 22.83038  ? 459 VAL F CG2 1 
ATOM   3034 N N   . ASN A 1 425 ? 158.25300 347.14500 25.17900  1.000 21.00479  ? 460 ASN F N   1 
ATOM   3035 C CA  . ASN A 1 425 ? 157.84300 345.74200 25.18200  1.000 22.01671  ? 460 ASN F CA  1 
ATOM   3036 C C   . ASN A 1 425 ? 156.78700 345.50600 26.27600  1.000 21.85836  ? 460 ASN F C   1 
ATOM   3037 O O   . ASN A 1 425 ? 156.96800 345.90600 27.43400  1.000 25.18132  ? 460 ASN F O   1 
ATOM   3038 C CB  . ASN A 1 425 ? 159.10400 344.91800 25.44600  1.000 27.04773  ? 460 ASN F CB  1 
ATOM   3039 C CG  . ASN A 1 425 ? 158.89100 343.40500 25.39300  1.000 33.18264  ? 460 ASN F CG  1 
ATOM   3040 O OD1 . ASN A 1 425 ? 157.89600 342.85200 25.86200  1.000 32.79612  ? 460 ASN F OD1 1 
ATOM   3041 N ND2 . ASN A 1 425 ? 159.86500 342.73200 24.81400  1.000 31.71058  ? 460 ASN F ND2 1 
ATOM   3042 N N   . LYS A 1 426 ? 155.64800 344.90200 25.89800  1.000 26.50738  ? 461 LYS F N   1 
ATOM   3043 C CA  . LYS A 1 426 ? 154.54400 344.68200 26.83400  1.000 34.95363  ? 461 LYS F CA  1 
ATOM   3044 C C   . LYS A 1 426 ? 154.60300 343.32300 27.53600  1.000 36.83347  ? 461 LYS F C   1 
ATOM   3045 O O   . LYS A 1 426 ? 153.58300 342.83700 28.03900  1.000 34.59170  ? 461 LYS F O   1 
ATOM   3046 C CB  . LYS A 1 426 ? 153.20200 344.86900 26.11400  1.000 25.36473  ? 461 LYS F CB  1 
ATOM   3047 C CG  . LYS A 1 426 ? 153.01000 346.20800 25.40700  1.000 32.70319  ? 461 LYS F CG  1 
ATOM   3048 C CD  . LYS A 1 426 ? 153.18800 347.41100 26.35300  1.000 31.08612  ? 461 LYS F CD  1 
ATOM   3049 C CE  . LYS A 1 426 ? 152.05300 347.35600 27.41200  1.000 35.51753  ? 461 LYS F CE  1 
ATOM   3050 N NZ  . LYS A 1 426 ? 152.00200 348.40300 28.49700  1.000 25.59180  ? 461 LYS F NZ  1 
ATOM   3051 N N   . GLN A 1 427 ? 155.79000 342.77500 27.69700  1.000 33.32918  ? 462 GLN F N   1 
ATOM   3052 C CA  . GLN A 1 427 ? 155.99700 341.50100 28.37300  1.000 34.94236  ? 462 GLN F CA  1 
ATOM   3053 C C   . GLN A 1 427 ? 155.82700 341.68200 29.88100  1.000 32.70831  ? 462 GLN F C   1 
ATOM   3054 O O   . GLN A 1 427 ? 156.22500 342.70200 30.44600  1.000 32.20017  ? 462 GLN F O   1 
ATOM   3055 C CB  . GLN A 1 427 ? 157.37700 340.97100 27.98100  1.000 34.56069  ? 462 GLN F CB  1 
ATOM   3056 C CG  . GLN A 1 427 ? 158.19700 340.28900 29.00400  1.000 39.27819  ? 462 GLN F CG  1 
ATOM   3057 C CD  . GLN A 1 427 ? 159.54300 339.93000 28.42800  1.000 48.80894  ? 462 GLN F CD  1 
ATOM   3058 O OE1 . GLN A 1 427 ? 160.20900 340.77000 27.79900  1.000 45.57737  ? 462 GLN F OE1 1 
ATOM   3059 N NE2 . GLN A 1 427 ? 159.93200 338.66100 28.57600  1.000 57.15629  ? 462 GLN F NE2 1 
ATOM   3060 N N   . GLU A 1 428 ? 155.22500 340.70100 30.54100  1.000 33.92026  ? 463 GLU F N   1 
ATOM   3061 C CA  . GLU A 1 428 ? 155.00200 340.79000 31.98300  1.000 32.44024  ? 463 GLU F CA  1 
ATOM   3062 C C   . GLU A 1 428 ? 156.24700 340.49800 32.80100  1.000 28.96778  ? 463 GLU F C   1 
ATOM   3063 O O   . GLU A 1 428 ? 157.12000 339.73100 32.39100  1.000 31.69428  ? 463 GLU F O   1 
ATOM   3064 C CB  . GLU A 1 428 ? 153.88000 339.86000 32.44000  1.000 44.25077  ? 463 GLU F CB  1 
ATOM   3065 C CG  . GLU A 1 428 ? 152.89600 339.52500 31.36500  1.000 56.60677  ? 463 GLU F CG  1 
ATOM   3066 C CD  . GLU A 1 428 ? 151.71100 338.77000 31.91100  1.000 68.21419  ? 463 GLU F CD  1 
ATOM   3067 O OE1 . GLU A 1 428 ? 151.81800 337.52400 31.98700  1.000 71.15798  ? 463 GLU F OE1 1 
ATOM   3068 O OE2 . GLU A 1 428 ? 150.69500 339.40900 32.27700  1.000 71.50655  ? 463 GLU F OE2 1 
ATOM   3069 N N   . GLY A 1 429 ? 156.41900 341.28800 33.84500  1.000 27.69740  ? 464 GLY F N   1 
ATOM   3070 C CA  . GLY A 1 429 ? 157.54700 341.15900 34.73900  1.000 26.85174  ? 464 GLY F CA  1 
ATOM   3071 C C   . GLY A 1 429 ? 157.52300 342.32000 35.69600  1.000 24.90644  ? 464 GLY F C   1 
ATOM   3072 O O   . GLY A 1 429 ? 156.71300 343.23200 35.57400  1.000 32.01685  ? 464 GLY F O   1 
ATOM   3073 N N   . LYS A 1 430 ? 158.43800 342.28100 36.65300  1.000 26.13323  ? 465 LYS F N   1 
ATOM   3074 C CA  . LYS A 1 430 ? 158.53600 343.30700 37.68700  1.000 28.29113  ? 465 LYS F CA  1 
ATOM   3075 C C   . LYS A 1 430 ? 159.79300 344.14300 37.47200  1.000 29.48211  ? 465 LYS F C   1 
ATOM   3076 O O   . LYS A 1 430 ? 160.89400 343.59000 37.35100  1.000 28.46934  ? 465 LYS F O   1 
ATOM   3077 C CB  . LYS A 1 430 ? 158.57700 342.68200 39.08300  1.000 27.86994  ? 465 LYS F CB  1 
ATOM   3078 C CG  . LYS A 1 430 ? 158.09700 343.61900 40.20000  1.000 46.95974  ? 465 LYS F CG  1 
ATOM   3079 C CD  . LYS A 1 430 ? 156.55600 343.69100 40.22900  1.000 59.13201  ? 465 LYS F CD  1 
ATOM   3080 C CE  . LYS A 1 430 ? 156.03700 345.13900 40.34900  1.000 57.25055  ? 465 LYS F CE  1 
ATOM   3081 N NZ  . LYS A 1 430 ? 154.66900 345.28400 39.74100  1.000 58.22129  ? 465 LYS F NZ  1 
ATOM   3082 N N   . SER A 1 431 ? 159.62900 345.46600 37.44400  1.000 24.67803  ? 466 SER F N   1 
ATOM   3083 C CA  . SER A 1 431 ? 160.74400 346.40400 37.40700  1.000 27.22368  ? 466 SER F CA  1 
ATOM   3084 C C   . SER A 1 431 ? 160.98900 347.01000 38.77800  1.000 27.67180  ? 466 SER F C   1 
ATOM   3085 O O   . SER A 1 431 ? 160.06100 347.30300 39.52600  1.000 27.87665  ? 466 SER F O   1 
ATOM   3086 C CB  . SER A 1 431 ? 160.49500 347.55900 36.43100  1.000 23.95178  ? 466 SER F CB  1 
ATOM   3087 O OG  . SER A 1 431 ? 160.32400 347.09200 35.10900  1.000 29.93389  ? 466 SER F OG  1 
ATOM   3088 N N   . LEU A 1 432 ? 162.24700 347.29800 39.04600  1.000 24.62862  ? 467 LEU F N   1 
ATOM   3089 C CA  . LEU A 1 432 ? 162.67500 347.89500 40.29300  1.000 25.78516  ? 467 LEU F CA  1 
ATOM   3090 C C   . LEU A 1 432 ? 163.54300 349.09500 39.94300  1.000 28.60610  ? 467 LEU F C   1 
ATOM   3091 O O   . LEU A 1 432 ? 164.54000 348.95500 39.22400  1.000 27.21886  ? 467 LEU F O   1 
ATOM   3092 C CB  . LEU A 1 432 ? 163.47100 346.91500 41.15600  1.000 24.58480  ? 467 LEU F CB  1 
ATOM   3093 C CG  . LEU A 1 432 ? 163.94700 347.49100 42.49800  1.000 32.63846  ? 467 LEU F CG  1 
ATOM   3094 C CD1 . LEU A 1 432 ? 162.76000 347.99200 43.34900  1.000 35.13825  ? 467 LEU F CD1 1 
ATOM   3095 C CD2 . LEU A 1 432 ? 164.89000 346.55400 43.28600  1.000 27.68148  ? 467 LEU F CD2 1 
ATOM   3096 N N   . TYR A 1 433 ? 163.13200 350.26900 40.40400  1.000 31.32678  ? 468 TYR F N   1 
ATOM   3097 C CA  . TYR A 1 433 ? 163.85000 351.51800 40.18700  1.000 24.42300  ? 468 TYR F CA  1 
ATOM   3098 C C   . TYR A 1 433 ? 164.76300 351.68800 41.38900  1.000 27.44703  ? 468 TYR F C   1 
ATOM   3099 O O   . TYR A 1 433 ? 164.28600 351.94700 42.49800  1.000 29.28445  ? 468 TYR F O   1 
ATOM   3100 C CB  . TYR A 1 433 ? 162.88200 352.69500 40.10300  1.000 22.76345  ? 468 TYR F CB  1 
ATOM   3101 C CG  . TYR A 1 433 ? 163.45500 353.96900 39.49100  1.000 23.07171  ? 468 TYR F CG  1 
ATOM   3102 C CD1 . TYR A 1 433 ? 164.35000 354.75400 40.20700  1.000 19.44886  ? 468 TYR F CD1 1 
ATOM   3103 C CD2 . TYR A 1 433 ? 162.99900 354.45200 38.26900  1.000 17.97988  ? 468 TYR F CD2 1 
ATOM   3104 C CE1 . TYR A 1 433 ? 164.85500 355.94600 39.67900  1.000 19.74535  ? 468 TYR F CE1 1 
ATOM   3105 C CE2 . TYR A 1 433 ? 163.48300 355.63900 37.74100  1.000 15.95575  ? 468 TYR F CE2 1 
ATOM   3106 C CZ  . TYR A 1 433 ? 164.42300 356.37300 38.43900  1.000 17.10670  ? 468 TYR F CZ  1 
ATOM   3107 O OH  . TYR A 1 433 ? 164.91000 357.55200 37.89800  1.000 22.22137  ? 468 TYR F OH  1 
ATOM   3108 N N   . VAL A 1 434 ? 166.06900 351.52300 41.19400  1.000 24.30236  ? 469 VAL F N   1 
ATOM   3109 C CA  . VAL A 1 434 ? 167.03600 351.64600 42.27900  1.000 19.91256  ? 469 VAL F CA  1 
ATOM   3110 C C   . VAL A 1 434 ? 167.54200 353.09300 42.30600  1.000 31.94391  ? 469 VAL F C   1 
ATOM   3111 O O   . VAL A 1 434 ? 168.43600 353.47300 41.53600  1.000 22.76022  ? 469 VAL F O   1 
ATOM   3112 C CB  . VAL A 1 434 ? 168.18700 350.64300 42.13500  1.000 22.10771  ? 469 VAL F CB  1 
ATOM   3113 C CG1 . VAL A 1 434 ? 169.16900 350.82200 43.28600  1.000 21.00801  ? 469 VAL F CG1 1 
ATOM   3114 C CG2 . VAL A 1 434 ? 167.67100 349.18900 42.07900  1.000 18.25555  ? 469 VAL F CG2 1 
ATOM   3115 N N   . LYS A 1 435 ? 166.99500 353.90600 43.20900  1.000 28.60027  ? 470 LYS F N   1 
ATOM   3116 C CA  . LYS A 1 435 ? 167.38900 355.30300 43.28400  1.000 27.05733  ? 470 LYS F CA  1 
ATOM   3117 C C   . LYS A 1 435 ? 168.82200 355.42800 43.77100  1.000 26.78127  ? 470 LYS F C   1 
ATOM   3118 O O   . LYS A 1 435 ? 169.33900 354.57200 44.49400  1.000 27.31187  ? 470 LYS F O   1 
ATOM   3119 C CB  . LYS A 1 435 ? 166.50300 356.09700 44.24700  1.000 28.15036  ? 470 LYS F CB  1 
ATOM   3120 C CG  . LYS A 1 435 ? 165.21600 356.62700 43.65800  1.000 40.99415  ? 470 LYS F CG  1 
ATOM   3121 C CD  . LYS A 1 435 ? 164.31000 357.16900 44.75000  1.000 42.84860  ? 470 LYS F CD  1 
ATOM   3122 C CE  . LYS A 1 435 ? 162.95900 357.59200 44.17300  1.000 61.33162  ? 470 LYS F CE  1 
ATOM   3123 N NZ  . LYS A 1 435 ? 162.23600 358.54300 45.08800  1.000 64.15355  ? 470 LYS F NZ  1 
ATOM   3124 N N   . GLY A 1 436 ? 169.48400 356.47900 43.30600  1.000 25.89720  ? 471 GLY F N   1 
ATOM   3125 C CA  . GLY A 1 436 ? 170.84600 356.72200 43.70200  1.000 23.90309  ? 471 GLY F CA  1 
ATOM   3126 C C   . GLY A 1 436 ? 171.34500 357.95100 42.99700  1.000 27.43566  ? 471 GLY F C   1 
ATOM   3127 O O   . GLY A 1 436 ? 170.85900 358.29500 41.91900  1.000 27.44352  ? 471 GLY F O   1 
ATOM   3128 N N   . GLU A 1 437 ? 172.29700 358.62200 43.61000  1.000 24.61597  ? 472 GLU F N   1 
ATOM   3129 C CA  . GLU A 1 437 ? 172.86700 359.83100 43.03700  1.000 30.65078  ? 472 GLU F CA  1 
ATOM   3130 C C   . GLU A 1 437 ? 173.66600 359.52700 41.77200  1.000 26.16955  ? 472 GLU F C   1 
ATOM   3131 O O   . GLU A 1 437 ? 174.52000 358.63800 41.79600  1.000 24.67577  ? 472 GLU F O   1 
ATOM   3132 C CB  . GLU A 1 437 ? 173.73100 360.53400 44.07200  1.000 31.44262  ? 472 GLU F CB  1 
ATOM   3133 C CG  . GLU A 1 437 ? 174.40900 361.74400 43.50100  1.000 33.07647  ? 472 GLU F CG  1 
ATOM   3134 C CD  . GLU A 1 437 ? 173.50600 362.95600 43.56400  1.000 42.78747  ? 472 GLU F CD  1 
ATOM   3135 O OE1 . GLU A 1 437 ? 172.50700 362.90200 44.31200  1.000 56.14223  ? 472 GLU F OE1 1 
ATOM   3136 O OE2 . GLU A 1 437 ? 173.76800 363.94300 42.83700  1.000 46.22355  ? 472 GLU F OE2 1 
ATOM   3137 N N   . PRO A 1 438 ? 173.44000 360.24100 40.66600  1.000 24.53188  ? 473 PRO F N   1 
ATOM   3138 C CA  . PRO A 1 438 ? 174.26300 359.99100 39.46700  1.000 25.82524  ? 473 PRO F CA  1 
ATOM   3139 C C   . PRO A 1 438 ? 175.74400 360.22700 39.74500  1.000 24.39477  ? 473 PRO F C   1 
ATOM   3140 O O   . PRO A 1 438 ? 176.16100 361.29800 40.19500  1.000 21.57752  ? 473 PRO F O   1 
ATOM   3141 C CB  . PRO A 1 438 ? 173.70600 360.99000 38.44100  1.000 25.97746  ? 473 PRO F CB  1 
ATOM   3142 C CG  . PRO A 1 438 ? 172.28200 361.27900 38.92700  1.000 28.69121  ? 473 PRO F CG  1 
ATOM   3143 C CD  . PRO A 1 438 ? 172.37200 361.23000 40.42900  1.000 25.80868  ? 473 PRO F CD  1 
ATOM   3144 N N   . ILE A 1 439 ? 176.54600 359.20100 39.45100  1.000 19.33432  ? 474 ILE F N   1 
ATOM   3145 C CA  . ILE A 1 439 ? 177.95900 359.26900 39.80800  1.000 20.51927  ? 474 ILE F CA  1 
ATOM   3146 C C   . ILE A 1 439 ? 178.70000 360.32600 39.02600  1.000 21.98975  ? 474 ILE F C   1 
ATOM   3147 O O   . ILE A 1 439 ? 179.73900 360.80300 39.50000  1.000 21.87041  ? 474 ILE F O   1 
ATOM   3148 C CB  . ILE A 1 439 ? 178.67300 357.91200 39.64000  1.000 20.42592  ? 474 ILE F CB  1 
ATOM   3149 C CG1 . ILE A 1 439 ? 178.78900 357.54000 38.16900  1.000 18.69751  ? 474 ILE F CG1 1 
ATOM   3150 C CG2 . ILE A 1 439 ? 177.91100 356.81400 40.40000  1.000 16.80489  ? 474 ILE F CG2 1 
ATOM   3151 C CD1 . ILE A 1 439 ? 179.56700 356.23400 37.91800  1.000 21.24253  ? 474 ILE F CD1 1 
ATOM   3152 N N   . ILE A 1 440 ? 178.12200 360.83600 37.93300  1.000 19.19115  ? 475 ILE F N   1 
ATOM   3153 C CA  . ILE A 1 440 ? 178.82000 361.88100 37.20600  1.000 18.88161  ? 475 ILE F CA  1 
ATOM   3154 C C   . ILE A 1 440 ? 178.88700 363.13400 38.07200  1.000 23.69257  ? 475 ILE F C   1 
ATOM   3155 O O   . ILE A 1 440 ? 179.77400 363.96600 37.87800  1.000 21.53989  ? 475 ILE F O   1 
ATOM   3156 C CB  . ILE A 1 440 ? 178.10600 362.17900 35.86300  1.000 22.47796  ? 475 ILE F CB  1 
ATOM   3157 C CG1 . ILE A 1 440 ? 178.96900 363.02300 34.91400  1.000 19.93199  ? 475 ILE F CG1 1 
ATOM   3158 C CG2 . ILE A 1 440 ? 176.74100 362.86500 36.08900  1.000 19.94385  ? 475 ILE F CG2 1 
ATOM   3159 C CD1 . ILE A 1 440 ? 180.25600 362.35800 34.50200  1.000 21.89523  ? 475 ILE F CD1 1 
ATOM   3160 N N   . ASN A 1 441 ? 177.99700 363.26900 39.06400  1.000 23.38993  ? 476 ASN F N   1 
ATOM   3161 C CA  . ASN A 1 441 ? 178.03600 364.43600 39.94400  1.000 29.03541  ? 476 ASN F CA  1 
ATOM   3162 C C   . ASN A 1 441 ? 179.16200 364.38200 40.96600  1.000 27.12841  ? 476 ASN F C   1 
ATOM   3163 O O   . ASN A 1 441 ? 179.40000 365.39100 41.62600  1.000 26.60978  ? 476 ASN F O   1 
ATOM   3164 C CB  . ASN A 1 441 ? 176.72300 364.60800 40.72700  1.000 22.65226  ? 476 ASN F CB  1 
ATOM   3165 C CG  . ASN A 1 441 ? 175.53400 364.83500 39.84700  1.000 24.53059  ? 476 ASN F CG  1 
ATOM   3166 O OD1 . ASN A 1 441 ? 175.65400 365.33200 38.72800  1.000 28.45249  ? 476 ASN F OD1 1 
ATOM   3167 N ND2 . ASN A 1 441 ? 174.36100 364.51000 40.36100  1.000 29.55747  ? 476 ASN F ND2 1 
ATOM   3168 N N   . PHE A 1 442 ? 179.83500 363.24200 41.13600  1.000 25.48515  ? 477 PHE F N   1 
ATOM   3169 C CA  . PHE A 1 442 ? 180.94500 363.13900 42.07900  1.000 26.01909  ? 477 PHE F CA  1 
ATOM   3170 C C   . PHE A 1 442 ? 182.26500 363.60800 41.49500  1.000 28.08605  ? 477 PHE F C   1 
ATOM   3171 O O   . PHE A 1 442 ? 183.26500 363.57500 42.20800  1.000 34.60706  ? 477 PHE F O   1 
ATOM   3172 C CB  . PHE A 1 442 ? 181.17500 361.68900 42.53100  1.000 29.17109  ? 477 PHE F CB  1 
ATOM   3173 C CG  . PHE A 1 442 ? 180.01700 361.05300 43.23000  1.000 33.25044  ? 477 PHE F CG  1 
ATOM   3174 C CD1 . PHE A 1 442 ? 179.15900 361.80300 44.00600  1.000 37.34898  ? 477 PHE F CD1 1 
ATOM   3175 C CD2 . PHE A 1 442 ? 179.79200 359.69000 43.10100  1.000 27.76064  ? 477 PHE F CD2 1 
ATOM   3176 C CE1 . PHE A 1 442 ? 178.09800 361.20700 44.66800  1.000 37.73653  ? 477 PHE F CE1 1 
ATOM   3177 C CE2 . PHE A 1 442 ? 178.73000 359.08400 43.75000  1.000 30.60699  ? 477 PHE F CE2 1 
ATOM   3178 C CZ  . PHE A 1 442 ? 177.87900 359.84900 44.53400  1.000 36.90101  ? 477 PHE F CZ  1 
ATOM   3179 N N   . TYR A 1 443 ? 182.28400 364.14100 40.27800  1.000 28.54825  ? 478 TYR F N   1 
ATOM   3180 C CA  . TYR A 1 443 ? 183.52600 364.45000 39.58300  1.000 27.07912  ? 478 TYR F CA  1 
ATOM   3181 C C   . TYR A 1 443 ? 183.69200 365.95000 39.41100  1.000 30.10620  ? 478 TYR F C   1 
ATOM   3182 O O   . TYR A 1 443 ? 182.71800 366.65000 39.12000  1.000 31.11840  ? 478 TYR F O   1 
ATOM   3183 C CB  . TYR A 1 443 ? 183.54600 363.79900 38.19000  1.000 22.19867  ? 478 TYR F CB  1 
ATOM   3184 C CG  . TYR A 1 443 ? 183.73500 362.30200 38.23200  1.000 25.93459  ? 478 TYR F CG  1 
ATOM   3185 C CD1 . TYR A 1 443 ? 184.98100 361.72700 38.41000  1.000 22.19934  ? 478 TYR F CD1 1 
ATOM   3186 C CD2 . TYR A 1 443 ? 182.62800 361.46300 38.12200  1.000 21.48996  ? 478 TYR F CD2 1 
ATOM   3187 C CE1 . TYR A 1 443 ? 185.11800 360.35000 38.47200  1.000 19.83361  ? 478 TYR F CE1 1 
ATOM   3188 C CE2 . TYR A 1 443 ? 182.75400 360.10200 38.17400  1.000 23.79672  ? 478 TYR F CE2 1 
ATOM   3189 C CZ  . TYR A 1 443 ? 184.00000 359.54600 38.34700  1.000 26.69567  ? 478 TYR F CZ  1 
ATOM   3190 O OH  . TYR A 1 443 ? 184.09400 358.17500 38.40100  1.000 26.45935  ? 478 TYR F OH  1 
ATOM   3191 N N   . ASP A 1 444 ? 184.87700 366.45100 39.71300  1.000 29.90108  ? 479 ASP F N   1 
ATOM   3192 C CA  . ASP A 1 444 ? 185.14300 367.85000 39.43700  1.000 33.77232  ? 479 ASP F CA  1 
ATOM   3193 C C   . ASP A 1 444 ? 185.31700 368.01700 37.93500  1.000 30.88058  ? 479 ASP F C   1 
ATOM   3194 O O   . ASP A 1 444 ? 186.21700 367.40300 37.34900  1.000 32.29818  ? 479 ASP F O   1 
ATOM   3195 C CB  . ASP A 1 444 ? 186.40800 368.30100 40.15900  1.000 37.10784  ? 479 ASP F CB  1 
ATOM   3196 C CG  . ASP A 1 444 ? 186.78900 369.74300 39.83900  1.000 42.39640  ? 479 ASP F CG  1 
ATOM   3197 O OD1 . ASP A 1 444 ? 185.96500 370.51300 39.30200  1.000 42.99749  ? 479 ASP F OD1 1 
ATOM   3198 O OD2 . ASP A 1 444 ? 187.94000 370.11500 40.13900  1.000 57.71921  ? 479 ASP F OD2 1 
ATOM   3199 N N   . PRO A 1 445 ? 184.56100 368.91700 37.30600  1.000 35.06857  ? 480 PRO F N   1 
ATOM   3200 C CA  . PRO A 1 445 ? 184.63100 369.05300 35.84500  1.000 29.30869  ? 480 PRO F CA  1 
ATOM   3201 C C   . PRO A 1 445 ? 185.99800 369.48900 35.36400  1.000 37.13289  ? 480 PRO F C   1 
ATOM   3202 O O   . PRO A 1 445 ? 186.42100 369.12200 34.25800  1.000 36.75335  ? 480 PRO F O   1 
ATOM   3203 C CB  . PRO A 1 445 ? 183.58500 370.12700 35.55500  1.000 34.45606  ? 480 PRO F CB  1 
ATOM   3204 C CG  . PRO A 1 445 ? 182.61100 370.04400 36.67000  1.000 31.90121  ? 480 PRO F CG  1 
ATOM   3205 C CD  . PRO A 1 445 ? 183.19800 369.19400 37.78100  1.000 32.98481  ? 480 PRO F CD  1 
ATOM   3206 N N   . LEU A 1 446 ? 186.65600 370.36100 36.12900  1.000 33.45053  ? 481 LEU F N   1 
ATOM   3207 C CA  . LEU A 1 446 ? 187.90600 370.95500 35.66800  1.000 38.38660  ? 481 LEU F CA  1 
ATOM   3208 C C   . LEU A 1 446 ? 188.94700 369.88000 35.39500  1.000 37.75603  ? 481 LEU F C   1 
ATOM   3209 O O   . LEU A 1 446 ? 189.77700 370.04800 34.49600  1.000 43.23299  ? 481 LEU F O   1 
ATOM   3210 C CB  . LEU A 1 446 ? 188.36700 372.02700 36.65900  1.000 42.04321  ? 481 LEU F CB  1 
ATOM   3211 C CG  . LEU A 1 446 ? 187.17800 373.01000 36.77300  1.000 41.11020  ? 481 LEU F CG  1 
ATOM   3212 C CD1 . LEU A 1 446 ? 187.05700 373.78100 38.09800  1.000 46.66471  ? 481 LEU F CD1 1 
ATOM   3213 C CD2 . LEU A 1 446 ? 187.16400 373.96500 35.57900  1.000 43.25880  ? 481 LEU F CD2 1 
ATOM   3214 N N   . VAL A 1 447 ? 189.03300 368.85400 36.24400  1.000 34.81999  ? 482 VAL F N   1 
ATOM   3215 C CA  . VAL A 1 447 ? 190.04200 367.81900 36.05000  1.000 34.91193  ? 482 VAL F CA  1 
ATOM   3216 C C   . VAL A 1 447 ? 189.44500 366.52000 35.47000  1.000 37.94512  ? 482 VAL F C   1 
ATOM   3217 O O   . VAL A 1 447 ? 190.15800 365.51200 35.38200  1.000 33.31273  ? 482 VAL F O   1 
ATOM   3218 C CB  . VAL A 1 447 ? 190.81800 367.54300 37.35500  1.000 38.29006  ? 482 VAL F CB  1 
ATOM   3219 C CG1 . VAL A 1 447 ? 191.61800 368.77500 37.77100  1.000 42.15108  ? 482 VAL F CG1 1 
ATOM   3220 C CG2 . VAL A 1 447 ? 189.87100 367.16600 38.47600  1.000 33.44019  ? 482 VAL F CG2 1 
ATOM   3221 N N   . PHE A 1 448 ? 188.17500 366.52100 35.01900  1.000 31.39858  ? 483 PHE F N   1 
ATOM   3222 C CA  . PHE A 1 448 ? 187.60200 365.26000 34.52500  1.000 26.85098  ? 483 PHE F CA  1 
ATOM   3223 C C   . PHE A 1 448 ? 188.31200 364.88100 33.22400  1.000 28.86123  ? 483 PHE F C   1 
ATOM   3224 O O   . PHE A 1 448 ? 188.30700 365.68700 32.29200  1.000 23.73658  ? 483 PHE F O   1 
ATOM   3225 C CB  . PHE A 1 448 ? 186.11400 365.43000 34.26900  1.000 26.09574  ? 483 PHE F CB  1 
ATOM   3226 C CG  . PHE A 1 448 ? 185.38100 364.15000 34.01400  1.000 21.58340  ? 483 PHE F CG  1 
ATOM   3227 C CD1 . PHE A 1 448 ? 185.32100 363.14700 34.97100  1.000 19.91109  ? 483 PHE F CD1 1 
ATOM   3228 C CD2 . PHE A 1 448 ? 184.81700 363.92400 32.76700  1.000 16.86808  ? 483 PHE F CD2 1 
ATOM   3229 C CE1 . PHE A 1 448 ? 184.65100 361.97100 34.71300  1.000 22.48327  ? 483 PHE F CE1 1 
ATOM   3230 C CE2 . PHE A 1 448 ? 184.13900 362.73500 32.49100  1.000 22.43376  ? 483 PHE F CE2 1 
ATOM   3231 C CZ  . PHE A 1 448 ? 184.05900 361.75600 33.46300  1.000 20.60447  ? 483 PHE F CZ  1 
ATOM   3232 N N   . PRO A 1 449 ? 188.68700 363.57000 33.01400  1.000 23.13340  ? 484 PRO F N   1 
ATOM   3233 C CA  . PRO A 1 449 ? 189.20400 363.19700 31.68800  1.000 25.36095  ? 484 PRO F CA  1 
ATOM   3234 C C   . PRO A 1 449 ? 188.09800 362.94400 30.71100  1.000 20.96001  ? 484 PRO F C   1 
ATOM   3235 O O   . PRO A 1 449 ? 187.55200 361.84100 30.66000  1.000 21.44006  ? 484 PRO F O   1 
ATOM   3236 C CB  . PRO A 1 449 ? 189.93100 361.87000 31.93900  1.000 21.54738  ? 484 PRO F CB  1 
ATOM   3237 C CG  . PRO A 1 449 ? 189.95600 361.68900 33.39100  1.000 29.05913  ? 484 PRO F CG  1 
ATOM   3238 C CD  . PRO A 1 449 ? 188.78600 362.44800 33.94800  1.000 21.84705  ? 484 PRO F CD  1 
ATOM   3239 N N   . SER A 1 450 ? 187.83700 363.88900 29.85300  1.000 18.98112  ? 485 SER F N   1 
ATOM   3240 C CA  . SER A 1 450 ? 186.69600 363.69700 28.99200  1.000 24.17966  ? 485 SER F CA  1 
ATOM   3241 C C   . SER A 1 450 ? 187.28300 363.14500 27.69700  1.000 27.92792  ? 485 SER F C   1 
ATOM   3242 O O   . SER A 1 450 ? 188.50300 363.16400 27.48400  1.000 30.82396  ? 485 SER F O   1 
ATOM   3243 C CB  . SER A 1 450 ? 185.89100 364.99800 28.85400  1.000 24.44801  ? 485 SER F CB  1 
ATOM   3244 O OG  . SER A 1 450 ? 186.69900 366.00600 28.29500  1.000 49.02459  ? 485 SER F OG  1 
ATOM   3245 N N   . ASP A 1 451 ? 186.48800 362.51600 26.87000  1.000 25.21779  ? 486 ASP F N   1 
ATOM   3246 C CA  . ASP A 1 451 ? 186.96800 361.85700 25.63200  1.000 21.07720  ? 486 ASP F CA  1 
ATOM   3247 C C   . ASP A 1 451 ? 187.80100 360.58800 25.79800  1.000 26.04417  ? 486 ASP F C   1 
ATOM   3248 O O   . ASP A 1 451 ? 188.72400 360.36800 25.06400  1.000 20.22494  ? 486 ASP F O   1 
ATOM   3249 C CB  . ASP A 1 451 ? 187.69400 362.81600 24.68800  1.000 24.39661  ? 486 ASP F CB  1 
ATOM   3250 C CG  . ASP A 1 451 ? 187.36300 362.55300 23.23400  1.000 30.81012  ? 486 ASP F CG  1 
ATOM   3251 O OD1 . ASP A 1 451 ? 186.56200 361.64400 22.96300  1.000 25.79885  ? 486 ASP F OD1 1 
ATOM   3252 O OD2 . ASP A 1 451 ? 187.90000 363.25100 22.36200  1.000 25.94159  ? 486 ASP F OD2 1 
ATOM   3253 N N   . GLU A 1 452 ? 187.46500 359.77700 26.77300  1.000 23.61783  ? 487 GLU F N   1 
ATOM   3254 C CA  . GLU A 1 452 ? 188.12700 358.51000 26.94000  1.000 19.01543  ? 487 GLU F CA  1 
ATOM   3255 C C   . GLU A 1 452 ? 187.29500 357.48500 26.17800  1.000 18.85066  ? 487 GLU F C   1 
ATOM   3256 O O   . GLU A 1 452 ? 186.12000 357.37500 26.40800  1.000 21.53860  ? 487 GLU F O   1 
ATOM   3257 C CB  . GLU A 1 452 ? 188.32100 358.19200 28.41600  1.000 20.89503  ? 487 GLU F CB  1 
ATOM   3258 C CG  . GLU A 1 452 ? 189.17600 359.18900 29.16600  1.000 23.81516  ? 487 GLU F CG  1 
ATOM   3259 C CD  . GLU A 1 452 ? 190.65200 359.00900 28.89700  1.000 28.67811  ? 487 GLU F CD  1 
ATOM   3260 O OE1 . GLU A 1 452 ? 191.10400 357.86200 28.78300  1.000 29.12860  ? 487 GLU F OE1 1 
ATOM   3261 O OE2 . GLU A 1 452 ? 191.36400 360.01600 28.80000  1.000 31.11657  ? 487 GLU F OE2 1 
ATOM   3262 N N   . PHE A 1 453 ? 187.88800 356.80600 25.22700  1.000 19.29499  ? 488 PHE F N   1 
ATOM   3263 C CA  . PHE A 1 453 ? 187.22200 355.81000 24.40200  1.000 27.20955  ? 488 PHE F CA  1 
ATOM   3264 C C   . PHE A 1 453 ? 186.98900 354.48300 25.07500  1.000 23.30668  ? 488 PHE F C   1 
ATOM   3265 O O   . PHE A 1 453 ? 185.88200 354.00500 25.08400  1.000 28.87377  ? 488 PHE F O   1 
ATOM   3266 C CB  . PHE A 1 453 ? 188.11900 355.59800 23.16600  1.000 29.33875  ? 488 PHE F CB  1 
ATOM   3267 C CG  . PHE A 1 453 ? 187.77600 354.41000 22.32900  1.000 35.15795  ? 488 PHE F CG  1 
ATOM   3268 C CD1 . PHE A 1 453 ? 186.68700 354.43100 21.48600  1.000 47.02614  ? 488 PHE F CD1 1 
ATOM   3269 C CD2 . PHE A 1 453 ? 188.58200 353.29400 22.34400  1.000 39.08402  ? 488 PHE F CD2 1 
ATOM   3270 C CE1 . PHE A 1 453 ? 186.38200 353.34100 20.69700  1.000 53.78424  ? 488 PHE F CE1 1 
ATOM   3271 C CE2 . PHE A 1 453 ? 188.28800 352.19900 21.56400  1.000 43.52951  ? 488 PHE F CE2 1 
ATOM   3272 C CZ  . PHE A 1 453 ? 187.18700 352.22100 20.73500  1.000 55.70426  ? 488 PHE F CZ  1 
ATOM   3273 N N   . ASP A 1 454 ? 188.04400 353.84800 25.53300  1.000 28.43499  ? 489 ASP F N   1 
ATOM   3274 C CA  . ASP A 1 454 ? 187.97600 352.56900 26.24200  1.000 26.24502  ? 489 ASP F CA  1 
ATOM   3275 C C   . ASP A 1 454 ? 188.41900 352.64000 27.70100  1.000 24.43472  ? 489 ASP F C   1 
ATOM   3276 O O   . ASP A 1 454 ? 189.49600 352.13700 28.00300  1.000 26.27734  ? 489 ASP F O   1 
ATOM   3277 C CB  . ASP A 1 454 ? 188.77100 351.49100 25.52300  1.000 38.86091  ? 489 ASP F CB  1 
ATOM   3278 C CG  . ASP A 1 454 ? 188.20500 350.10800 25.77100  1.000 34.44566  ? 489 ASP F CG  1 
ATOM   3279 O OD1 . ASP A 1 454 ? 187.35300 349.97800 26.67700  1.000 31.11764  ? 489 ASP F OD1 1 
ATOM   3280 O OD2 . ASP A 1 454 ? 188.65400 349.15900 25.11000  1.000 44.78252  ? 489 ASP F OD2 1 
ATOM   3281 N N   . ALA A 1 455 ? 187.77100 353.39800 28.57100  1.000 23.51590  ? 490 ALA F N   1 
ATOM   3282 C CA  . ALA A 1 455 ? 188.35800 353.53300 29.88800  1.000 22.35190  ? 490 ALA F CA  1 
ATOM   3283 C C   . ALA A 1 455 ? 187.71700 352.63600 30.97400  1.000 28.30501  ? 490 ALA F C   1 
ATOM   3284 O O   . ALA A 1 455 ? 186.99600 351.66200 30.70700  1.000 27.91376  ? 490 ALA F O   1 
ATOM   3285 C CB  . ALA A 1 455 ? 188.35100 355.00000 30.29700  1.000 21.18371  ? 490 ALA F CB  1 
ATOM   3286 N N   . SER A 1 456 ? 188.02700 352.96700 32.22200  1.000 19.21119  ? 491 SER F N   1 
ATOM   3287 C CA  . SER A 1 456 ? 187.57300 352.29100 33.43100  1.000 26.85300  ? 491 SER F CA  1 
ATOM   3288 C C   . SER A 1 456 ? 187.49300 353.26900 34.59400  1.000 24.34929  ? 491 SER F C   1 
ATOM   3289 O O   . SER A 1 456 ? 188.15800 354.31000 34.61700  1.000 24.76521  ? 491 SER F O   1 
ATOM   3290 C CB  . SER A 1 456 ? 188.50100 351.14200 33.82400  1.000 21.36237  ? 491 SER F CB  1 
ATOM   3291 O OG  . SER A 1 456 ? 189.62900 351.69000 34.48100  1.000 26.26823  ? 491 SER F OG  1 
ATOM   3292 N N   . ILE A 1 457 ? 186.73400 352.87200 35.60800  1.000 25.24682  ? 492 ILE F N   1 
ATOM   3293 C CA  . ILE A 1 457 ? 186.58000 353.72000 36.78500  1.000 21.50687  ? 492 ILE F CA  1 
ATOM   3294 C C   . ILE A 1 457 ? 187.96000 353.99800 37.40600  1.000 25.14050  ? 492 ILE F C   1 
ATOM   3295 O O   . ILE A 1 457 ? 188.29600 355.15100 37.72000  1.000 21.94070  ? 492 ILE F O   1 
ATOM   3296 C CB  . ILE A 1 457 ? 185.65300 353.00400 37.78900  1.000 22.64588  ? 492 ILE F CB  1 
ATOM   3297 C CG1 . ILE A 1 457 ? 184.17000 353.21600 37.42100  1.000 27.79234  ? 492 ILE F CG1 1 
ATOM   3298 C CG2 . ILE A 1 457 ? 185.94900 353.45700 39.21000  1.000 24.02541  ? 492 ILE F CG2 1 
ATOM   3299 C CD1 . ILE A 1 457 ? 183.64000 354.61700 37.57700  1.000 24.12200  ? 492 ILE F CD1 1 
ATOM   3300 N N   . SER A 1 458 ? 188.77500 352.94800 37.62900  1.000 21.62791  ? 493 SER F N   1 
ATOM   3301 C CA  . SER A 1 458 ? 190.11900 353.18400 38.18200  1.000 30.95711  ? 493 SER F CA  1 
ATOM   3302 C C   . SER A 1 458 ? 191.04900 353.93300 37.21800  1.000 27.25997  ? 493 SER F C   1 
ATOM   3303 O O   . SER A 1 458 ? 191.89100 354.72300 37.66000  1.000 23.38009  ? 493 SER F O   1 
ATOM   3304 C CB  . SER A 1 458 ? 190.75600 351.85700 38.58900  1.000 26.33770  ? 493 SER F CB  1 
ATOM   3305 O OG  . SER A 1 458 ? 189.96100 351.25700 39.59700  1.000 37.76600  ? 493 SER F OG  1 
ATOM   3306 N N   . GLN A 1 459 ? 190.85200 353.76300 35.90700  1.000 25.29807  ? 494 GLN F N   1 
ATOM   3307 C CA  . GLN A 1 459 ? 191.63700 354.50200 34.91700  1.000 27.93506  ? 494 GLN F CA  1 
ATOM   3308 C C   . GLN A 1 459 ? 191.32300 355.98400 35.04900  1.000 32.68878  ? 494 GLN F C   1 
ATOM   3309 O O   . GLN A 1 459 ? 192.22900 356.83200 35.07100  1.000 29.41632  ? 494 GLN F O   1 
ATOM   3310 C CB  . GLN A 1 459 ? 191.29000 353.96100 33.52300  1.000 30.85917  ? 494 GLN F CB  1 
ATOM   3311 C CG  . GLN A 1 459 ? 191.98800 352.66300 33.14100  1.000 30.27587  ? 494 GLN F CG  1 
ATOM   3312 C CD  . GLN A 1 459 ? 191.79100 352.28200 31.67400  1.000 34.09944  ? 494 GLN F CD  1 
ATOM   3313 O OE1 . GLN A 1 459 ? 191.23200 351.20900 31.41400  1.000 32.96686  ? 494 GLN F OE1 1 
ATOM   3314 N NE2 . GLN A 1 459 ? 192.16900 353.15200 30.72600  1.000 30.51627  ? 494 GLN F NE2 1 
ATOM   3315 N N   . VAL A 1 460 ? 190.03300 356.31000 35.19500  1.000 27.83207  ? 495 VAL F N   1 
ATOM   3316 C CA  . VAL A 1 460 ? 189.65800 357.71300 35.30200  1.000 26.39762  ? 495 VAL F CA  1 
ATOM   3317 C C   . VAL A 1 460 ? 190.20100 358.27000 36.60600  1.000 29.82414  ? 495 VAL F C   1 
ATOM   3318 O O   . VAL A 1 460 ? 190.66700 359.41200 36.65900  1.000 31.38278  ? 495 VAL F O   1 
ATOM   3319 C CB  . VAL A 1 460 ? 188.13300 357.87300 35.20600  1.000 22.48321  ? 495 VAL F CB  1 
ATOM   3320 C CG1 . VAL A 1 460 ? 187.73800 359.32500 35.46500  1.000 24.80211  ? 495 VAL F CG1 1 
ATOM   3321 C CG2 . VAL A 1 460 ? 187.66900 357.45300 33.82400  1.000 24.60374  ? 495 VAL F CG2 1 
ATOM   3322 N N   . ASN A 1 461 ? 190.13000 357.49300 37.68700  1.000 26.32578  ? 496 ASN F N   1 
ATOM   3323 C CA  . ASN A 1 461 ? 190.64500 358.01100 38.94800  1.000 31.65895  ? 496 ASN F CA  1 
ATOM   3324 C C   . ASN A 1 461 ? 192.16100 358.26400 38.88900  1.000 36.80618  ? 496 ASN F C   1 
ATOM   3325 O O   . ASN A 1 461 ? 192.64200 359.24300 39.46600  1.000 36.68593  ? 496 ASN F O   1 
ATOM   3326 C CB  . ASN A 1 461 ? 190.32700 357.05500 40.09400  1.000 30.68283  ? 496 ASN F CB  1 
ATOM   3327 C CG  . ASN A 1 461 ? 188.86000 357.07700 40.49800  1.000 35.83215  ? 496 ASN F CG  1 
ATOM   3328 O OD1 . ASN A 1 461 ? 188.13600 358.04200 40.23400  1.000 37.01067  ? 496 ASN F OD1 1 
ATOM   3329 N ND2 . ASN A 1 461 ? 188.41900 356.01200 41.16700  1.000 32.89599  ? 496 ASN F ND2 1 
ATOM   3330 N N   . GLU A 1 462 ? 192.94900 357.40000 38.21100  1.000 36.39738  ? 497 GLU F N   1 
ATOM   3331 C CA  . GLU A 1 462 ? 194.38000 357.73800 38.13400  1.000 44.90211  ? 497 GLU F CA  1 
ATOM   3332 C C   . GLU A 1 462 ? 194.62800 358.95900 37.26100  1.000 44.05610  ? 497 GLU F C   1 
ATOM   3333 O O   . GLU A 1 462 ? 195.52100 359.76200 37.55100  1.000 40.95012  ? 497 GLU F O   1 
ATOM   3334 C CB  . GLU A 1 462 ? 195.30800 356.62300 37.63300  1.000 41.41678  ? 497 GLU F CB  1 
ATOM   3335 C CG  . GLU A 1 462 ? 195.45500 356.47300 36.12700  1.000 50.22656  ? 497 GLU F CG  1 
ATOM   3336 C CD  . GLU A 1 462 ? 196.17000 355.17900 35.71100  1.000 60.97653  ? 497 GLU F CD  1 
ATOM   3337 O OE1 . GLU A 1 462 ? 196.85500 354.56800 36.57000  1.000 54.90195  ? 497 GLU F OE1 1 
ATOM   3338 O OE2 . GLU A 1 462 ? 195.98800 354.73500 34.54700  1.000 57.41259  ? 497 GLU F OE2 1 
ATOM   3339 N N   . LYS A 1 463 ? 193.85900 359.12300 36.18600  1.000 42.84183  ? 498 LYS F N   1 
ATOM   3340 C CA  . LYS A 1 463 ? 194.03800 360.34300 35.40800  1.000 42.22748  ? 498 LYS F CA  1 
ATOM   3341 C C   . LYS A 1 463 ? 193.64300 361.58000 36.21400  1.000 41.20115  ? 498 LYS F C   1 
ATOM   3342 O O   . LYS A 1 463 ? 194.29800 362.62300 36.10400  1.000 44.81865  ? 498 LYS F O   1 
ATOM   3343 C CB  . LYS A 1 463 ? 193.27500 360.24100 34.09500  1.000 38.57398  ? 498 LYS F CB  1 
ATOM   3344 C CG  . LYS A 1 463 ? 194.05800 359.47500 33.05700  1.000 40.04054  ? 498 LYS F CG  1 
ATOM   3345 C CD  . LYS A 1 463 ? 193.28100 359.30400 31.79200  1.000 42.95886  ? 498 LYS F CD  1 
ATOM   3346 C CE  . LYS A 1 463 ? 194.16000 359.59300 30.58000  1.000 50.93910  ? 498 LYS F CE  1 
ATOM   3347 N NZ  . LYS A 1 463 ? 193.97200 358.55300 29.51000  1.000 45.71801  ? 498 LYS F NZ  1 
ATOM   3348 N N   . ILE A 1 464 ? 192.71200 361.44300 37.15400  1.000 40.43213  ? 499 ILE F N   1 
ATOM   3349 C CA  . ILE A 1 464 ? 192.36600 362.60100 37.97300  1.000 42.76521  ? 499 ILE F CA  1 
ATOM   3350 C C   . ILE A 1 464 ? 193.44600 362.86100 39.00500  1.000 46.70642  ? 499 ILE F C   1 
ATOM   3351 O O   . ILE A 1 464 ? 193.77200 364.01700 39.28300  1.000 51.91484  ? 499 ILE F O   1 
ATOM   3352 C CB  . ILE A 1 464 ? 190.97900 362.40600 38.62300  1.000 41.95531  ? 499 ILE F CB  1 
ATOM   3353 C CG1 . ILE A 1 464 ? 189.90700 362.27200 37.53800  1.000 33.08181  ? 499 ILE F CG1 1 
ATOM   3354 C CG2 . ILE A 1 464 ? 190.64900 363.49500 39.65700  1.000 37.29413  ? 499 ILE F CG2 1 
ATOM   3355 C CD1 . ILE A 1 464 ? 188.55000 362.01900 38.06400  1.000 25.87152  ? 499 ILE F CD1 1 
ATOM   3356 N N   . ASN A 1 465 ? 194.04300 361.80700 39.56300  1.000 43.49409  ? 500 ASN F N   1 
ATOM   3357 C CA  . ASN A 1 465 ? 195.15100 362.02300 40.49200  1.000 53.36101  ? 500 ASN F CA  1 
ATOM   3358 C C   . ASN A 1 465 ? 196.37200 362.62300 39.80500  1.000 50.84171  ? 500 ASN F C   1 
ATOM   3359 O O   . ASN A 1 465 ? 197.04600 363.48600 40.37800  1.000 54.24697  ? 500 ASN F O   1 
ATOM   3360 C CB  . ASN A 1 465 ? 195.55700 360.69900 41.12700  1.000 49.21096  ? 500 ASN F CB  1 
ATOM   3361 C CG  . ASN A 1 465 ? 194.62800 360.27400 42.22200  1.000 59.04217  ? 500 ASN F CG  1 
ATOM   3362 O OD1 . ASN A 1 465 ? 193.51400 360.77700 42.33600  1.000 58.66745  ? 500 ASN F OD1 1 
ATOM   3363 N ND2 . ASN A 1 465 ? 195.07400 359.30800 43.02400  1.000 71.28599  ? 500 ASN F ND2 1 
ATOM   3364 N N   . GLN A 1 466 ? 196.58600 362.28500 38.54000  1.000 48.80325  ? 501 GLN F N   1 
ATOM   3365 C CA  . GLN A 1 466 ? 197.70600 362.84800 37.80400  1.000 55.07703  ? 501 GLN F CA  1 
ATOM   3366 C C   . GLN A 1 466 ? 197.44700 364.27900 37.35700  1.000 65.16821  ? 501 GLN F C   1 
ATOM   3367 O O   . GLN A 1 466 ? 198.39500 365.05900 37.22600  1.000 70.82016  ? 501 GLN F O   1 
ATOM   3368 C CB  . GLN A 1 466 ? 198.01600 361.96700 36.59800  1.000 53.42437  ? 501 GLN F CB  1 
ATOM   3369 C CG  . GLN A 1 466 ? 198.54000 360.59600 36.93800  1.000 59.25617  ? 501 GLN F CG  1 
ATOM   3370 C CD  . GLN A 1 466 ? 198.72600 359.71700 35.71200  1.000 63.30326  ? 501 GLN F CD  1 
ATOM   3371 O OE1 . GLN A 1 466 ? 197.80500 359.49800 34.90200  1.000 65.66148  ? 501 GLN F OE1 1 
ATOM   3372 N NE2 . GLN A 1 466 ? 199.94300 359.25400 35.54200  1.000 72.15236  ? 501 GLN F NE2 1 
ATOM   3373 N N   . SER A 1 467 ? 196.19900 364.63900 37.05400  1.000 63.61293  ? 502 SER F N   1 
ATOM   3374 C CA  . SER A 1 467 ? 195.95100 366.02700 36.69700  1.000 62.07642  ? 502 SER F CA  1 
ATOM   3375 C C   . SER A 1 467 ? 195.87500 366.89700 37.95200  1.000 68.67271  ? 502 SER F C   1 
ATOM   3376 O O   . SER A 1 467 ? 196.12600 368.10700 37.87300  1.000 77.70350  ? 502 SER F O   1 
ATOM   3377 C CB  . SER A 1 467 ? 194.70700 366.14600 35.81000  1.000 48.37879  ? 502 SER F CB  1 
ATOM   3378 O OG  . SER A 1 467 ? 193.55800 365.64100 36.45500  1.000 69.93043  ? 502 SER F OG  1 
ATOM   3379 N N   . LEU A 1 468 ? 195.54700 366.29800 39.11000  1.000 63.65159  ? 503 LEU F N   1 
ATOM   3380 C CA  . LEU A 1 468 ? 195.54600 367.01200 40.38000  1.000 60.56574  ? 503 LEU F CA  1 
ATOM   3381 C C   . LEU A 1 468 ? 196.94400 367.20100 40.94700  1.000 82.02034  ? 503 LEU F C   1 
ATOM   3382 O O   . LEU A 1 468 ? 197.15400 368.12600 41.73800  1.000 89.33682  ? 503 LEU F O   1 
ATOM   3383 C CB  . LEU A 1 468 ? 194.72200 366.25600 41.42500  1.000 57.27435  ? 503 LEU F CB  1 
ATOM   3384 C CG  . LEU A 1 468 ? 193.20000 366.23400 41.46300  1.000 59.68475  ? 503 LEU F CG  1 
ATOM   3385 C CD1 . LEU A 1 468 ? 192.75700 365.37600 42.62200  1.000 54.49017  ? 503 LEU F CD1 1 
ATOM   3386 C CD2 . LEU A 1 468 ? 192.67800 367.65200 41.66600  1.000 49.50863  ? 503 LEU F CD2 1 
ATOM   3387 N N   . ALA A 1 469 ? 197.89300 366.30600 40.62700  1.000 84.05425  ? 504 ALA F N   1 
ATOM   3388 C CA  . ALA A 1 469 ? 199.26900 366.53100 41.07500  1.000 87.07101  ? 504 ALA F CA  1 
ATOM   3389 C C   . ALA A 1 469 ? 199.94800 367.71000 40.37300  1.000 90.28153  ? 504 ALA F C   1 
ATOM   3390 O O   . ALA A 1 469 ? 200.77200 368.39500 40.99100  1.000 96.55982  ? 504 ALA F O   1 
ATOM   3391 C CB  . ALA A 1 469 ? 200.09600 365.26100 40.87900  1.000 73.48283  ? 504 ALA F CB  1 
ATOM   3392 N N   . PHE A 1 470 ? 199.61000 367.98700 39.10700  1.000 88.45861  ? 505 PHE F N   1 
ATOM   3393 C CA  . PHE A 1 470 ? 200.19400 369.14700 38.43600  1.000 87.75046  ? 505 PHE F CA  1 
ATOM   3394 C C   . PHE A 1 470 ? 199.70200 370.46500 39.01700  1.000 93.31476  ? 505 PHE F C   1 
ATOM   3395 O O   . PHE A 1 470 ? 200.38800 371.48500 38.88300  1.000 96.61181  ? 505 PHE F O   1 
ATOM   3396 C CB  . PHE A 1 470 ? 199.87100 369.14500 36.93800  1.000 89.39314  ? 505 PHE F CB  1 
ATOM   3397 C CG  . PHE A 1 470 ? 200.34600 367.92400 36.19500  1.000 97.05677  ? 505 PHE F CG  1 
ATOM   3398 C CD1 . PHE A 1 470 ? 201.47900 367.23300 36.59700  1.000 93.82347  ? 505 PHE F CD1 1 
ATOM   3399 C CD2 . PHE A 1 470 ? 199.66000 367.48200 35.06300  1.000 101.01082 ? 505 PHE F CD2 1 
ATOM   3400 C CE1 . PHE A 1 470 ? 201.91200 366.10800 35.89400  1.000 98.94212  ? 505 PHE F CE1 1 
ATOM   3401 C CE2 . PHE A 1 470 ? 200.08400 366.36000 34.35500  1.000 102.58383 ? 505 PHE F CE2 1 
ATOM   3402 C CZ  . PHE A 1 470 ? 201.21200 365.67300 34.77100  1.000 102.98204 ? 505 PHE F CZ  1 
ATOM   3403 N N   . ILE A 1 471 ? 198.57300 370.44400 39.72400  1.000 94.23612  ? 506 ILE F N   1 
ATOM   3404 C CA  . ILE A 1 471 ? 197.99100 371.62300 40.35400  1.000 94.07068  ? 506 ILE F CA  1 
ATOM   3405 C C   . ILE A 1 471 ? 198.37600 371.66400 41.82100  1.000 98.33477  ? 506 ILE F C   1 
ATOM   3406 O O   . ILE A 1 471 ? 198.41800 372.74000 42.43000  1.000 103.89474 ? 506 ILE F O   1 
ATOM   3407 C CB  . ILE A 1 471 ? 196.45900 371.63200 40.18900  1.000 86.74719  ? 506 ILE F CB  1 
ATOM   3408 C CG1 . ILE A 1 471 ? 196.07500 371.36500 38.73000  1.000 83.84574  ? 506 ILE F CG1 1 
ATOM   3409 C CG2 . ILE A 1 471 ? 195.87300 372.94300 40.67800  1.000 93.29654  ? 506 ILE F CG2 1 
ATOM   3410 C CD1 . ILE A 1 471 ? 194.58200 371.32600 38.49300  1.000 78.52875  ? 506 ILE F CD1 1 
ATOM   3411 N N   . ARG A 1 472 ? 198.63000 370.49500 42.40700  1.000 96.77537  ? 507 ARG F N   1 
ATOM   3412 C CA  . ARG A 1 472 ? 199.01700 370.46400 43.81000  1.000 96.72150  ? 507 ARG F CA  1 
ATOM   3413 C C   . ARG A 1 472 ? 200.35500 371.16700 43.98000  1.000 100.59748 ? 507 ARG F C   1 
ATOM   3414 O O   . ARG A 1 472 ? 200.53600 371.98200 44.89300  1.000 102.40281 ? 507 ARG F O   1 
ATOM   3415 C CB  . ARG A 1 472 ? 199.07100 369.02100 44.30700  1.000 95.89548  ? 507 ARG F CB  1 
ATOM   3416 C CG  . ARG A 1 472 ? 197.71800 368.47900 44.74700  1.000 97.84706  ? 507 ARG F CG  1 
ATOM   3417 C CD  . ARG A 1 472 ? 197.39300 368.92300 46.16400  1.000 100.28195 ? 507 ARG F CD  1 
ATOM   3418 N NE  . ARG A 1 472 ? 198.27600 368.28800 47.13500  1.000 99.55757  ? 507 ARG F NE  1 
ATOM   3419 C CZ  . ARG A 1 472 ? 198.10200 368.32500 48.44900  1.000 103.46728 ? 507 ARG F CZ  1 
ATOM   3420 N NH1 . ARG A 1 472 ? 197.07600 368.96300 48.99200  1.000 101.50745 ? 507 ARG F NH1 1 
ATOM   3421 N NH2 . ARG A 1 472 ? 198.97500 367.70200 49.23700  1.000 102.64573 ? 507 ARG F NH2 1 
ATOM   3422 N N   . LYS A 1 473 ? 201.31100 370.85700 43.09900  1.000 104.76450 ? 508 LYS F N   1 
ATOM   3423 C CA  . LYS A 1 473 ? 202.61400 371.50400 43.17000  1.000 104.84256 ? 508 LYS F CA  1 
ATOM   3424 C C   . LYS A 1 473 ? 202.49600 372.97900 42.81100  1.000 106.14530 ? 508 LYS F C   1 
ATOM   3425 O O   . LYS A 1 473 ? 203.24700 373.81000 43.33300  1.000 110.20587 ? 508 LYS F O   1 
ATOM   3426 C CB  . LYS A 1 473 ? 203.60400 370.80100 42.24000  1.000 101.19676 ? 508 LYS F CB  1 
ATOM   3427 C CG  . LYS A 1 473 ? 204.27300 369.58500 42.86000  1.000 102.80099 ? 508 LYS F CG  1 
ATOM   3428 C CD  . LYS A 1 473 ? 204.04900 368.34600 42.00100  1.000 109.15568 ? 508 LYS F CD  1 
ATOM   3429 C CE  . LYS A 1 473 ? 204.82300 367.14200 42.51900  1.000 108.55606 ? 508 LYS F CE  1 
ATOM   3430 N NZ  . LYS A 1 473 ? 204.66700 365.95100 41.63000  1.000 106.42775 ? 508 LYS F NZ  1 
ATOM   3431 N N   . SER A 1 474 ? 201.53200 373.31900 41.95700  1.000 105.64737 ? 509 SER F N   1 
ATOM   3432 C CA  . SER A 1 474 ? 201.28900 374.69100 41.52300  1.000 102.74081 ? 509 SER F CA  1 
ATOM   3433 C C   . SER A 1 474 ? 200.06700 375.28900 42.22700  1.000 90.57994  ? 509 SER F C   1 
ATOM   3434 O O   . SER A 1 474 ? 200.02200 375.37000 43.45700  1.000 84.61768  ? 509 SER F O   1 
ATOM   3435 C CB  . SER A 1 474 ? 201.09800 374.73100 40.00000  1.000 95.55696  ? 509 SER F CB  1 
ATOM   3436 O OG  . SER A 1 474 ? 201.35500 376.02000 39.47200  1.000 90.56582  ? 509 SER F OG  1 
HETATM 3437 C C1  . NAG B 2 .   ? 194.35500 358.74700 44.13700  1.000 74.17928  ? 601 NAG F C1  1 
HETATM 3438 C C2  . NAG B 2 .   ? 194.45200 357.21000 44.12400  1.000 78.21197  ? 601 NAG F C2  1 
HETATM 3439 C C3  . NAG B 2 .   ? 193.81100 356.62500 45.38800  1.000 79.14297  ? 601 NAG F C3  1 
HETATM 3440 C C4  . NAG B 2 .   ? 194.39800 357.26300 46.64400  1.000 88.24710  ? 601 NAG F C4  1 
HETATM 3441 C C5  . NAG B 2 .   ? 194.27900 358.78400 46.57400  1.000 82.69937  ? 601 NAG F C5  1 
HETATM 3442 C C6  . NAG B 2 .   ? 194.93100 359.49600 47.74300  1.000 81.68825  ? 601 NAG F C6  1 
HETATM 3443 C C7  . NAG B 2 .   ? 194.47400 355.88200 42.03100  1.000 66.31281  ? 601 NAG F C7  1 
HETATM 3444 C C8  . NAG B 2 .   ? 193.65100 355.39100 40.87600  1.000 56.03069  ? 601 NAG F C8  1 
HETATM 3445 N N2  . NAG B 2 .   ? 193.83200 356.64800 42.92900  1.000 74.26894  ? 601 NAG F N2  1 
HETATM 3446 O O3  . NAG B 2 .   ? 194.02400 355.21700 45.40800  1.000 79.80489  ? 601 NAG F O3  1 
HETATM 3447 O O4  . NAG B 2 .   ? 193.72000 356.79000 47.80400  1.000 90.56568  ? 601 NAG F O4  1 
HETATM 3448 O O5  . NAG B 2 .   ? 194.91700 359.26700 45.38100  1.000 82.50090  ? 601 NAG F O5  1 
HETATM 3449 O O6  . NAG B 2 .   ? 196.09700 358.83000 48.20900  1.000 81.93372  ? 601 NAG F O6  1 
HETATM 3450 O O7  . NAG B 2 .   ? 195.66400 355.59600 42.14400  1.000 68.75365  ? 601 NAG F O7  1 
HETATM 3451 C C1  . EDO C 3 .   ? 178.14100 343.91000 34.45900  1.000 14.51246  ? 602 EDO F C1  1 
HETATM 3452 O O1  . EDO C 3 .   ? 179.23900 344.64600 33.91400  1.000 35.94076  ? 602 EDO F O1  1 
HETATM 3453 C C2  . EDO C 3 .   ? 177.36800 343.28200 33.28700  1.000 25.26937  ? 602 EDO F C2  1 
HETATM 3454 O O2  . EDO C 3 .   ? 176.42900 342.28700 33.70400  1.000 23.40154  ? 602 EDO F O2  1 
HETATM 3455 H H11 . EDO C 3 .   ? 177.48800 344.57200 35.03200  1.000 17.44511  ? 602 EDO F H11 1 
HETATM 3456 H H12 . EDO C 3 .   ? 178.50400 343.13100 35.13400  1.000 17.44511  ? 602 EDO F H12 1 
HETATM 3457 H HO1 . EDO C 3 .   ? 179.76600 345.01800 34.63500  1.000 43.15906  ? 602 EDO F HO1 1 
HETATM 3458 H H21 . EDO C 3 .   ? 178.08100 342.82900 32.59500  1.000 30.35340  ? 602 EDO F H21 1 
HETATM 3459 H H22 . EDO C 3 .   ? 176.83600 344.07000 32.75200  1.000 30.35340  ? 602 EDO F H22 1 
HETATM 3460 H HO2 . EDO C 3 .   ? 176.19700 341.72700 32.95100  1.000 28.11200  ? 602 EDO F HO2 1 
HETATM 3461 C C1  . EDO D 3 .   ? 182.01800 345.16200 32.04500  1.000 46.03392  ? 603 EDO F C1  1 
HETATM 3462 O O1  . EDO D 3 .   ? 183.29800 344.78200 31.49600  1.000 22.83415  ? 603 EDO F O1  1 
HETATM 3463 C C2  . EDO D 3 .   ? 182.13700 346.08000 33.27600  1.000 28.86335  ? 603 EDO F C2  1 
HETATM 3464 O O2  . EDO D 3 .   ? 182.80700 347.28500 32.96700  1.000 30.46981  ? 603 EDO F O2  1 
HETATM 3465 H H11 . EDO D 3 .   ? 181.47300 344.25900 32.32900  1.000 55.27086  ? 603 EDO F H11 1 
HETATM 3466 H H12 . EDO D 3 .   ? 181.44000 345.67500 31.27500  1.000 55.27086  ? 603 EDO F H12 1 
HETATM 3467 H HO1 . EDO D 3 .   ? 183.16400 344.16900 30.76000  1.000 27.43114  ? 603 EDO F HO1 1 
HETATM 3468 H H21 . EDO D 3 .   ? 182.68200 345.55700 34.06400  1.000 34.66617  ? 603 EDO F H21 1 
HETATM 3469 H H22 . EDO D 3 .   ? 181.13800 346.30900 33.65200  1.000 34.66617  ? 603 EDO F H22 1 
HETATM 3470 H HO2 . EDO D 3 .   ? 182.81100 347.86000 33.74400  1.000 36.59393  ? 603 EDO F HO2 1 
HETATM 3471 C C1  . EDO E 3 .   ? 175.63100 350.00500 40.59000  1.000 28.94793  ? 604 EDO F C1  1 
HETATM 3472 O O1  . EDO E 3 .   ? 176.58900 350.99600 41.02800  1.000 22.20205  ? 604 EDO F O1  1 
HETATM 3473 C C2  . EDO E 3 .   ? 175.00700 350.29600 39.21500  1.000 26.93278  ? 604 EDO F C2  1 
HETATM 3474 O O2  . EDO E 3 .   ? 175.94900 350.41800 38.11900  1.000 19.92883  ? 604 EDO F O2  1 
HETATM 3475 H H11 . EDO E 3 .   ? 174.83100 349.94200 41.33000  1.000 34.76767  ? 604 EDO F H11 1 
HETATM 3476 H H12 . EDO E 3 .   ? 176.12800 349.03400 40.54800  1.000 34.76767  ? 604 EDO F H12 1 
HETATM 3477 H HO1 . EDO E 3 .   ? 177.03900 350.68000 41.82300  1.000 26.67262  ? 604 EDO F HO1 1 
HETATM 3478 H H21 . EDO E 3 .   ? 174.43900 351.22600 39.28600  1.000 32.34949  ? 604 EDO F H21 1 
HETATM 3479 H H22 . EDO E 3 .   ? 174.30600 349.49300 38.97900  1.000 32.34949  ? 604 EDO F H22 1 
HETATM 3480 H HO2 . EDO E 3 .   ? 175.46500 350.49200 37.28500  1.000 23.94476  ? 604 EDO F HO2 1 
HETATM 3481 O O   . HOH F 4 .   ? 170.45000 325.40500 -9.22200  1.000 33.72611  ? 701 HOH F O   1 
HETATM 3482 O O   . HOH F 4 .   ? 178.435   376.599   22.020    1.000 38.19581  ? 702 HOH F O   1 
HETATM 3483 O O   . HOH F 4 .   ? 180.46100 331.13600 9.95700   1.000 49.31875  ? 703 HOH F O   1 
HETATM 3484 O O   . HOH F 4 .   ? 175.91300 333.40500 19.11500  1.000 30.51983  ? 704 HOH F O   1 
HETATM 3485 O O   . HOH F 4 .   ? 142.87700 354.05200 30.82300  1.000 50.31056  ? 705 HOH F O   1 
HETATM 3486 O O   . HOH F 4 .   ? 190.54900 362.46400 28.52800  1.000 37.12642  ? 706 HOH F O   1 
HETATM 3487 O O   . HOH F 4 .   ? 183.57000 322.10200 14.14800  1.000 27.74256  ? 707 HOH F O   1 
HETATM 3488 O O   . HOH F 4 .   ? 170.80100 355.88000 24.76700  1.000 25.36318  ? 708 HOH F O   1 
HETATM 3489 O O   . HOH F 4 .   ? 171.96400 303.33100 -1.23200  1.000 52.23265  ? 709 HOH F O   1 
HETATM 3490 O O   . HOH F 4 .   ? 148.95100 354.71400 32.13900  1.000 32.23262  ? 710 HOH F O   1 
HETATM 3491 O O   . HOH F 4 .   ? 155.21700 358.47100 22.82500  1.000 19.52362  ? 711 HOH F O   1 
HETATM 3492 O O   . HOH F 4 .   ? 165.67600 329.63100 10.20300  1.000 39.60484  ? 712 HOH F O   1 
HETATM 3493 O O   . HOH F 4 .   ? 185.48500 329.35200 34.59000  1.000 25.50470  ? 713 HOH F O   1 
HETATM 3494 O O   . HOH F 4 .   ? 152.90700 367.46800 23.72300  1.000 29.54966  ? 714 HOH F O   1 
HETATM 3495 O O   . HOH F 4 .   ? 155.30200 359.73200 24.92200  1.000 21.45678  ? 715 HOH F O   1 
HETATM 3496 O O   . HOH F 4 .   ? 172.27200 360.22500 24.57600  1.000 29.38547  ? 716 HOH F O   1 
HETATM 3497 O O   . HOH F 4 .   ? 187.63100 350.34500 39.88800  1.000 34.16447  ? 717 HOH F O   1 
HETATM 3498 O O   . HOH F 4 .   ? 185.03800 349.53000 39.72200  1.000 22.03142  ? 718 HOH F O   1 
HETATM 3499 O O   . HOH F 4 .   ? 187.08200 365.02900 37.66300  1.000 35.32583  ? 719 HOH F O   1 
HETATM 3500 O O   . HOH F 4 .   ? 162.88900 321.74400 -11.87500 1.000 39.80009  ? 720 HOH F O   1 
HETATM 3501 O O   . HOH F 4 .   ? 187.91500 347.75300 41.25100  1.000 32.66496  ? 721 HOH F O   1 
HETATM 3502 O O   . HOH F 4 .   ? 164.09900 337.58100 37.76000  1.000 31.65795  ? 722 HOH F O   1 
HETATM 3503 O O   . HOH F 4 .   ? 169.95500 347.31100 25.20400  1.000 26.84528  ? 723 HOH F O   1 
HETATM 3504 O O   . HOH F 4 .   ? 157.88800 337.49600 33.44000  1.000 31.63791  ? 724 HOH F O   1 
HETATM 3505 O O   . HOH F 4 .   ? 191.30000 348.71100 33.82300  1.000 35.37641  ? 725 HOH F O   1 
HETATM 3506 O O   . HOH F 4 .   ? 181.81900 364.90900 22.47000  1.000 28.24736  ? 726 HOH F O   1 
HETATM 3507 O O   . HOH F 4 .   ? 165.02900 368.62300 27.76400  1.000 26.65054  ? 727 HOH F O   1 
HETATM 3508 O O   . HOH F 4 .   ? 171.54300 371.60900 30.11300  1.000 40.74896  ? 728 HOH F O   1 
HETATM 3509 O O   . HOH F 4 .   ? 171.71300 353.85500 45.30500  1.000 42.79544  ? 729 HOH F O   1 
HETATM 3510 O O   . HOH F 4 .   ? 174.47900 360.33000 23.11600  1.000 37.18932  ? 730 HOH F O   1 
HETATM 3511 O O   . HOH F 4 .   ? 169.19200 335.88800 35.26600  1.000 21.56519  ? 731 HOH F O   1 
HETATM 3512 O O   . HOH F 4 .   ? 163.36000 312.72300 3.12700   1.000 46.15091  ? 732 HOH F O   1 
HETATM 3513 O O   . HOH F 4 .   ? 192.26000 352.31200 28.25300  1.000 29.50254  ? 733 HOH F O   1 
HETATM 3514 O O   . HOH F 4 .   ? 159.18100 363.94000 22.06200  1.000 23.62022  ? 734 HOH F O   1 
HETATM 3515 O O   . HOH F 4 .   ? 182.25000 322.68800 1.43500   1.000 42.07422  ? 735 HOH F O   1 
HETATM 3516 O O   . HOH F 4 .   ? 168.37500 375.30900 27.03200  1.000 34.59250  ? 736 HOH F O   1 
HETATM 3517 O O   . HOH F 4 .   ? 180.25000 366.68500 38.21700  1.000 26.38677  ? 737 HOH F O   1 
HETATM 3518 O O   . HOH F 4 .   ? 170.90200 326.31700 3.80000   1.000 28.73399  ? 738 HOH F O   1 
HETATM 3519 O O   . HOH F 4 .   ? 169.32900 328.84600 36.67800  1.000 35.91635  ? 739 HOH F O   1 
HETATM 3520 O O   . HOH F 4 .   ? 174.95100 321.23900 30.74300  1.000 25.10164  ? 740 HOH F O   1 
HETATM 3521 O O   . HOH F 4 .   ? 182.63500 332.59200 27.11200  1.000 18.08765  ? 741 HOH F O   1 
HETATM 3522 O O   . HOH F 4 .   ? 187.67600 333.92900 1.16500   1.000 37.22537  ? 742 HOH F O   1 
HETATM 3523 O O   . HOH F 4 .   ? 166.78900 367.56600 20.60200  1.000 26.40890  ? 743 HOH F O   1 
HETATM 3524 O O   . HOH F 4 .   ? 172.80500 340.43300 37.36400  1.000 32.00610  ? 744 HOH F O   1 
HETATM 3525 O O   . HOH F 4 .   ? 183.12300 326.80600 22.14400  1.000 24.05889  ? 745 HOH F O   1 
HETATM 3526 O O   . HOH F 4 .   ? 159.93800 362.49700 35.41700  1.000 29.64953  ? 746 HOH F O   1 
HETATM 3527 O O   . HOH F 4 .   ? 187.72700 336.14400 39.36600  1.000 20.28915  ? 747 HOH F O   1 
HETATM 3528 O O   . HOH F 4 .   ? 159.85700 355.82900 36.64000  1.000 28.59407  ? 748 HOH F O   1 
HETATM 3529 O O   . HOH F 4 .   ? 170.00700 317.05100 29.21500  1.000 39.25517  ? 749 HOH F O   1 
HETATM 3530 O O   . HOH F 4 .   ? 184.17800 370.67100 30.36100  1.000 47.32972  ? 750 HOH F O   1 
HETATM 3531 O O   . HOH F 4 .   ? 162.49500 315.46300 17.04600  1.000 38.44891  ? 751 HOH F O   1 
HETATM 3532 O O   . HOH F 4 .   ? 180.21900 328.74900 15.57500  1.000 30.13721  ? 752 HOH F O   1 
HETATM 3533 O O   . HOH F 4 .   ? 160.86800 326.23800 8.20800   1.000 45.83159  ? 753 HOH F O   1 
HETATM 3534 O O   . HOH F 4 .   ? 166.97500 360.63700 37.03700  1.000 31.86945  ? 754 HOH F O   1 
HETATM 3535 O O   . HOH F 4 .   ? 164.36500 327.25500 4.60000   1.000 39.67306  ? 755 HOH F O   1 
HETATM 3536 O O   . HOH F 4 .   ? 160.50700 347.58200 26.99200  1.000 21.18922  ? 756 HOH F O   1 
HETATM 3537 O O   . HOH F 4 .   ? 172.87300 357.82700 46.12900  1.000 44.45131  ? 757 HOH F O   1 
HETATM 3538 O O   . HOH F 4 .   ? 172.78100 363.53400 35.61900  1.000 23.64051  ? 758 HOH F O   1 
HETATM 3539 O O   . HOH F 4 .   ? 175.15400 352.59700 42.67800  1.000 37.35424  ? 759 HOH F O   1 
HETATM 3540 O O   . HOH F 4 .   ? 179.48400 332.33100 36.85000  1.000 24.72634  ? 760 HOH F O   1 
HETATM 3541 O O   . HOH F 4 .   ? 150.36500 348.17700 31.04000  1.000 34.68006  ? 761 HOH F O   1 
HETATM 3542 O O   . HOH F 4 .   ? 181.91700 336.76300 17.09000  1.000 43.34052  ? 762 HOH F O   1 
HETATM 3543 O O   . HOH F 4 .   ? 171.15600 353.59800 41.50400  1.000 20.54569  ? 763 HOH F O   1 
HETATM 3544 O O   . HOH F 4 .   ? 161.48100 358.99600 37.42900  1.000 32.86114  ? 764 HOH F O   1 
HETATM 3545 O O   . HOH F 4 .   ? 159.96300 366.26600 33.89200  1.000 23.55572  ? 765 HOH F O   1 
HETATM 3546 O O   . HOH F 4 .   ? 168.25600 353.00600 46.45200  1.000 44.23854  ? 766 HOH F O   1 
HETATM 3547 O O   . HOH F 4 .   ? 161.79800 366.42300 28.07000  1.000 15.95793  ? 767 HOH F O   1 
HETATM 3548 O O   . HOH F 4 .   ? 179.97700 359.00300 27.70900  1.000 20.47376  ? 768 HOH F O   1 
HETATM 3549 O O   . HOH F 4 .   ? 170.46900 359.21600 36.30200  1.000 20.63683  ? 769 HOH F O   1 
HETATM 3550 O O   . HOH F 4 .   ? 156.94200 349.61000 37.81400  1.000 36.91135  ? 770 HOH F O   1 
HETATM 3551 O O   . HOH F 4 .   ? 174.35600 340.60100 22.87300  1.000 29.67046  ? 771 HOH F O   1 
HETATM 3552 O O   . HOH F 4 .   ? 174.21800 334.95900 38.61600  1.000 39.38947  ? 772 HOH F O   1 
HETATM 3553 O O   . HOH F 4 .   ? 188.92300 319.29700 10.04800  1.000 41.57924  ? 773 HOH F O   1 
HETATM 3554 O O   . HOH F 4 .   ? 155.16200 352.69500 34.22300  1.000 35.00139  ? 774 HOH F O   1 
HETATM 3555 O O   . HOH F 4 .   ? 161.47500 321.60100 -4.00800  1.000 43.74974  ? 775 HOH F O   1 
HETATM 3556 O O   . HOH F 4 .   ? 178.64600 338.63900 20.63500  1.000 26.08613  ? 776 HOH F O   1 
HETATM 3557 O O   . HOH F 4 .   ? 172.08600 315.45500 25.36100  1.000 40.21546  ? 777 HOH F O   1 
HETATM 3558 O O   . HOH F 4 .   ? 162.65900 339.58600 26.61500  1.000 40.80926  ? 778 HOH F O   1 
HETATM 3559 O O   . HOH F 4 .   ? 165.93500 345.24800 24.85500  1.000 30.90590  ? 779 HOH F O   1 
HETATM 3560 O O   . HOH F 4 .   ? 181.18100 348.69500 24.99100  1.000 42.92973  ? 780 HOH F O   1 
HETATM 3561 O O   . HOH F 4 .   ? 185.36900 350.90200 28.39800  1.000 26.88853  ? 781 HOH F O   1 
HETATM 3562 O O   . HOH F 4 .   ? 175.52100 356.97900 43.79600  1.000 29.32450  ? 782 HOH F O   1 
HETATM 3563 O O   . HOH F 4 .   ? 153.87100 348.80200 23.33500  1.000 28.14489  ? 783 HOH F O   1 
HETATM 3564 O O   . HOH F 4 .   ? 187.83800 332.66900 33.48000  1.000 28.04133  ? 784 HOH F O   1 
HETATM 3565 O O   . HOH F 4 .   ? 156.61100 363.93800 23.20200  1.000 24.34494  ? 785 HOH F O   1 
HETATM 3566 O O   . HOH F 4 .   ? 171.75400 320.04500 22.12000  1.000 26.72675  ? 786 HOH F O   1 
HETATM 3567 O O   . HOH F 4 .   ? 180.97800 325.39700 29.37400  1.000 15.56768  ? 787 HOH F O   1 
HETATM 3568 O O   . HOH F 4 .   ? 151.15700 355.71600 23.30100  1.000 24.09911  ? 788 HOH F O   1 
HETATM 3569 O O   . HOH F 4 .   ? 167.72200 333.37600 35.51400  1.000 23.33600  ? 789 HOH F O   1 
HETATM 3570 O O   . HOH F 4 .   ? 187.56600 335.55000 26.43100  1.000 18.81400  ? 790 HOH F O   1 
HETATM 3571 O O   . HOH F 4 .   ? 158.058   355.240   15.379    1.000 26.55814  ? 791 HOH F O   1 
HETATM 3572 O O   . HOH F 4 .   ? 165.75100 343.07800 26.18400  1.000 30.38890  ? 792 HOH F O   1 
HETATM 3573 O O   . HOH F 4 .   ? 161.40500 366.80800 37.76900  1.000 39.23661  ? 793 HOH F O   1 
HETATM 3574 O O   . HOH F 4 .   ? 177.89700 349.80100 26.66100  1.000 29.09988  ? 794 HOH F O   1 
HETATM 3575 O O   . HOH F 4 .   ? 178.93800 345.70000 23.72900  1.000 33.00671  ? 795 HOH F O   1 
HETATM 3576 O O   . HOH F 4 .   ? 166.40500 350.57800 22.12100  1.000 22.62069  ? 796 HOH F O   1 
HETATM 3577 O O   . HOH F 4 .   ? 165.12100 369.20500 32.84000  1.000 37.13521  ? 797 HOH F O   1 
HETATM 3578 O O   . HOH F 4 .   ? 162.78600 327.03300 26.31900  1.000 36.28826  ? 798 HOH F O   1 
HETATM 3579 O O   . HOH F 4 .   ? 186.92800 364.70000 40.52000  1.000 33.47346  ? 799 HOH F O   1 
HETATM 3580 O O   . HOH F 4 .   ? 181.41500 345.64600 24.25600  1.000 32.96526  ? 800 HOH F O   1 
HETATM 3581 O O   . HOH F 4 .   ? 192.47500 364.47900 34.12700  1.000 42.37052  ? 801 HOH F O   1 
HETATM 3582 O O   . HOH F 4 .   ? 173.50700 367.92700 29.60600  1.000 24.36771  ? 802 HOH F O   1 
HETATM 3583 O O   . HOH F 4 .   ? 175.32600 308.96900 15.90500  1.000 48.75724  ? 803 HOH F O   1 
HETATM 3584 O O   . HOH F 4 .   ? 160.68700 350.54900 41.79200  1.000 31.47912  ? 804 HOH F O   1 
HETATM 3585 O O   . HOH F 4 .   ? 157.56100 346.25200 34.51100  1.000 30.35225  ? 805 HOH F O   1 
HETATM 3586 O O   . HOH F 4 .   ? 170.71600 361.76900 35.62800  1.000 15.29210  ? 806 HOH F O   1 
HETATM 3587 O O   . HOH F 4 .   ? 171.14300 369.06300 29.55800  1.000 22.64559  ? 807 HOH F O   1 
HETATM 3588 O O   . HOH F 4 .   ? 159.37200 346.94500 22.08100  1.000 35.85103  ? 808 HOH F O   1 
HETATM 3589 O O   . HOH F 4 .   ? 186.56000 337.38300 44.29100  1.000 48.30276  ? 809 HOH F O   1 
HETATM 3590 O O   . HOH F 4 .   ? 167.36400 333.41700 9.30200   1.000 48.49733  ? 810 HOH F O   1 
HETATM 3591 O O   . HOH F 4 .   ? 174.36500 323.31400 31.91600  1.000 23.17959  ? 811 HOH F O   1 
HETATM 3592 O O   . HOH F 4 .   ? 175.73500 354.13300 31.41300  1.000 12.60091  ? 812 HOH F O   1 
HETATM 3593 O O   . HOH F 4 .   ? 175.05900 330.84600 3.99700   1.000 41.48484  ? 813 HOH F O   1 
HETATM 3594 O O   . HOH F 4 .   ? 162.46700 312.75100 0.50400   1.000 41.03516  ? 814 HOH F O   1 
HETATM 3595 O O   . HOH F 4 .   ? 172.01600 345.88600 25.54200  1.000 22.24123  ? 815 HOH F O   1 
HETATM 3596 O O   . HOH F 4 .   ? 157.38200 357.47600 36.75600  1.000 45.64303  ? 816 HOH F O   1 
HETATM 3597 O O   . HOH F 4 .   ? 180.268   372.651   24.628    1.000 43.88933  ? 817 HOH F O   1 
HETATM 3598 O O   . HOH F 4 .   ? 179.63900 347.23500 32.27200  1.000 21.47997  ? 818 HOH F O   1 
HETATM 3599 O O   . HOH F 4 .   ? 184.93400 333.77300 37.82400  1.000 16.12386  ? 819 HOH F O   1 
HETATM 3600 O O   . HOH F 4 .   ? 163.65600 310.18700 -3.73800  1.000 42.53157  ? 820 HOH F O   1 
HETATM 3601 O O   . HOH F 4 .   ? 160.23200 321.67100 5.50100   1.000 36.40135  ? 821 HOH F O   1 
HETATM 3602 O O   . HOH F 4 .   ? 181.85800 332.05800 39.79400  1.000 31.98044  ? 822 HOH F O   1 
HETATM 3603 O O   . HOH F 4 .   ? 156.98500 346.63700 37.17700  1.000 37.76867  ? 823 HOH F O   1 
HETATM 3604 O O   . HOH F 4 .   ? 190.10800 360.23200 22.51300  1.000 24.31770  ? 824 HOH F O   1 
HETATM 3605 O O   . HOH F 4 .   ? 168.84900 370.57800 22.43000  1.000 21.89618  ? 825 HOH F O   1 
HETATM 3606 O O   . HOH F 4 .   ? 186.06800 368.23300 30.08200  1.000 44.72283  ? 826 HOH F O   1 
HETATM 3607 O O   . HOH F 4 .   ? 154.49200 308.89400 -13.86400 1.000 43.29512  ? 827 HOH F O   1 
HETATM 3608 O O   . HOH F 4 .   ? 189.07000 340.55300 42.42000  1.000 39.46154  ? 828 HOH F O   1 
HETATM 3609 O O   . HOH F 4 .   ? 177.47100 338.96800 41.69800  1.000 41.29324  ? 829 HOH F O   1 
HETATM 3610 O O   . HOH F 4 .   ? 172.13500 349.41900 25.87300  1.000 19.70687  ? 830 HOH F O   1 
HETATM 3611 O O   . HOH F 4 .   ? 180.60400 349.35900 33.89600  1.000 23.16437  ? 831 HOH F O   1 
HETATM 3612 O O   . HOH F 4 .   ? 167.49500 356.95500 20.80400  1.000 33.23129  ? 832 HOH F O   1 
HETATM 3613 O O   . HOH F 4 .   ? 162.28600 353.69300 43.83600  1.000 42.74362  ? 833 HOH F O   1 
HETATM 3614 O O   . HOH F 4 .   ? 175.72000 365.70600 44.22300  1.000 42.24454  ? 834 HOH F O   1 
HETATM 3615 O O   . HOH F 4 .   ? 149.13600 363.65900 25.50900  1.000 30.47539  ? 835 HOH F O   1 
HETATM 3616 O O   . HOH F 4 .   ? 158.984   362.967   13.428    1.000 19.68639  ? 836 HOH F O   1 
HETATM 3617 O O   . HOH F 4 .   ? 183.84300 315.76000 -5.23400  1.000 35.12424  ? 837 HOH F O   1 
HETATM 3618 O O   . HOH F 4 .   ? 158.42700 338.96800 37.51900  1.000 31.57239  ? 838 HOH F O   1 
HETATM 3619 O O   . HOH F 4 .   ? 165.40200 352.67700 45.42800  1.000 40.52435  ? 839 HOH F O   1 
HETATM 3620 O O   . HOH F 4 .   ? 171.79800 321.87600 33.27100  1.000 40.23337  ? 840 HOH F O   1 
HETATM 3621 O O   . HOH F 4 .   ? 177.11200 335.74600 38.42400  1.000 32.44455  ? 841 HOH F O   1 
HETATM 3622 O O   . HOH F 4 .   ? 180.11400 326.15100 -8.64400  1.000 42.52357  ? 842 HOH F O   1 
HETATM 3623 O O   . HOH F 4 .   ? 162.61000 344.69800 24.24700  1.000 33.26173  ? 843 HOH F O   1 
HETATM 3624 O O   . HOH F 4 .   ? 174.23900 367.94300 37.03800  1.000 35.89379  ? 844 HOH F O   1 
HETATM 3625 O O   . HOH F 4 .   ? 186.49900 333.48500 25.34300  1.000 24.07782  ? 845 HOH F O   1 
HETATM 3626 O O   . HOH F 4 .   ? 177.76600 326.28000 34.52500  1.000 18.67915  ? 846 HOH F O   1 
HETATM 3627 O O   . HOH F 4 .   ? 172.96100 365.48600 37.34400  1.000 40.24615  ? 847 HOH F O   1 
HETATM 3628 O O   . HOH F 4 .   ? 159.64300 313.74100 11.34500  1.000 48.17726  ? 848 HOH F O   1 
HETATM 3629 O O   . HOH F 4 .   ? 183.42200 324.42800 23.62900  1.000 28.75022  ? 849 HOH F O   1 
HETATM 3630 O O   . HOH F 4 .   ? 165.44300 361.40400 31.48700  1.000 24.85147  ? 850 HOH F O   1 
HETATM 3631 O O   . HOH F 4 .   ? 146.34800 350.65200 29.04600  1.000 46.27448  ? 851 HOH F O   1 
HETATM 3632 O O   . HOH F 4 .   ? 183.89900 315.01700 13.01700  1.000 37.47091  ? 852 HOH F O   1 
HETATM 3633 O O   . HOH F 4 .   ? 188.01000 340.76000 38.44900  1.000 24.55513  ? 853 HOH F O   1 
HETATM 3634 O O   . HOH F 4 .   ? 180.46200 314.57000 15.22800  1.000 42.66039  ? 854 HOH F O   1 
HETATM 3635 O O   . HOH F 4 .   ? 163.14200 369.08300 36.88300  1.000 34.05444  ? 855 HOH F O   1 
HETATM 3636 O O   . HOH F 4 .   ? 155.15900 343.67000 23.11000  1.000 41.13366  ? 856 HOH F O   1 
HETATM 3637 O O   . HOH F 4 .   ? 162.78300 367.82300 21.02000  1.000 12.36371  ? 857 HOH F O   1 
HETATM 3638 O O   . HOH F 4 .   ? 172.80700 348.62700 42.54400  1.000 44.77921  ? 858 HOH F O   1 
HETATM 3639 O O   . HOH F 4 .   ? 172.17400 350.97800 23.79400  1.000 39.23345  ? 859 HOH F O   1 
HETATM 3640 O O   . HOH F 4 .   ? 161.46300 327.69800 16.12300  1.000 43.47356  ? 860 HOH F O   1 
HETATM 3641 O O   . HOH F 4 .   ? 161.64400 325.19500 24.36800  1.000 36.66750  ? 861 HOH F O   1 
HETATM 3642 O O   . HOH F 4 .   ? 172.61200 368.60600 20.65800  1.000 35.34889  ? 862 HOH F O   1 
HETATM 3643 O O   . HOH F 4 .   ? 181.08000 309.74500 17.09800  1.000 43.31984  ? 863 HOH F O   1 
HETATM 3644 O O   . HOH F 4 .   ? 182.83700 323.52200 19.38300  1.000 26.23877  ? 864 HOH F O   1 
HETATM 3645 O O   . HOH F 4 .   ? 177.94100 348.18100 22.13800  1.000 41.56120  ? 865 HOH F O   1 
HETATM 3646 O O   . HOH F 4 .   ? 177.47600 356.51200 24.71600  1.000 39.53997  ? 866 HOH F O   1 
HETATM 3647 O O   . HOH F 4 .   ? 157.592   365.489   15.421    1.000 25.26208  ? 867 HOH F O   1 
HETATM 3648 O O   . HOH F 4 .   ? 183.86800 372.60800 26.30800  1.000 44.53769  ? 868 HOH F O   1 
HETATM 3649 O O   . HOH F 4 .   ? 173.385   372.014   21.348    1.000 35.84755  ? 869 HOH F O   1 
HETATM 3650 O O   . HOH F 4 .   ? 173.04200 370.10800 25.82900  1.000 43.79100  ? 870 HOH F O   1 
HETATM 3651 O O   . HOH F 4 .   ? 145.584   363.038   26.123    1.000 32.63290  ? 871 HOH F O   1 
HETATM 3652 O O   . HOH F 4 .   ? 174.66600 355.23100 23.63700  1.000 33.38523  ? 872 HOH F O   1 
HETATM 3653 O O   . HOH F 4 .   ? 188.12100 334.88800 34.55100  1.000 26.46880  ? 873 HOH F O   1 
HETATM 3654 O O   . HOH F 4 .   ? 172.80800 351.46400 42.65200  1.000 39.81646  ? 874 HOH F O   1 
HETATM 3655 O O   . HOH F 4 .   ? 176.97000 328.41700 35.70100  1.000 32.02665  ? 875 HOH F O   1 
HETATM 3656 O O   . HOH F 4 .   ? 186.28500 361.43500 41.91200  1.000 44.51695  ? 876 HOH F O   1 
HETATM 3657 O O   . HOH F 4 .   ? 166.23400 328.86400 7.81600   1.000 42.60931  ? 877 HOH F O   1 
HETATM 3658 O O   . HOH F 4 .   ? 178.84200 353.74900 24.29400  1.000 43.47632  ? 878 HOH F O   1 
HETATM 3659 O O   . HOH F 4 .   ? 151.51400 348.22400 23.10200  1.000 33.45436  ? 879 HOH F O   1 
HETATM 3660 O O   . HOH F 4 .   ? 189.61700 330.60600 9.53800   1.000 43.13042  ? 880 HOH F O   1 
HETATM 3661 O O   . HOH F 4 .   ? 172.75800 372.15600 27.62200  1.000 48.77193  ? 881 HOH F O   1 
HETATM 3662 O O   . HOH F 4 .   ? 184.99900 359.14000 42.40700  1.000 35.23950  ? 882 HOH F O   1 
HETATM 3663 O O   . HOH F 4 .   ? 163.221   370.469   34.903    1.000 26.87596  ? 883 HOH F O   1 
HETATM 3664 O O   . HOH F 4 .   ? 173.03500 345.22700 23.38900  1.000 34.61303  ? 884 HOH F O   1 
HETATM 3665 O O   . HOH F 4 .   ? 170.44700 372.60700 22.96900  1.000 32.43097  ? 885 HOH F O   1 
HETATM 3666 O O   . HOH F 4 .   ? 167.86300 331.12500 37.09200  1.000 35.35038  ? 886 HOH F O   1 
HETATM 3667 O O   . HOH F 4 .   ? 171.77600 355.03100 47.83900  1.000 45.94843  ? 887 HOH F O   1 
HETATM 3668 O O   . HOH F 4 .   ? 189.391   338.273   38.780    1.000 22.35958  ? 888 HOH F O   1 
HETATM 3669 O O   . HOH F 4 .   ? 177.92600 365.18300 45.55700  1.000 45.54266  ? 889 HOH F O   1 
HETATM 3670 O O   . HOH F 4 .   ? 170.34800 373.55500 26.09900  1.000 36.48206  ? 890 HOH F O   1 
HETATM 3671 O O   . HOH F 4 .   ? 184.89700 321.89700 16.94200  1.000 36.29821  ? 891 HOH F O   1 
HETATM 3672 O O   . HOH F 4 .   ? 160.87400 361.95800 39.20000  1.000 47.36848  ? 892 HOH F O   1 
HETATM 3673 O O   . HOH F 4 .   ? 150.155   363.072   23.267    1.000 26.19348  ? 893 HOH F O   1 
HETATM 3674 O O   . HOH F 4 .   ? 154.72000 355.10300 35.23300  1.000 42.00145  ? 894 HOH F O   1 
HETATM 3675 O O   . HOH F 4 .   ? 187.448   334.118   37.435    1.000 18.61766  ? 895 HOH F O   1 
HETATM 3676 O O   . HOH F 4 .   ? 190.493   339.098   40.902    1.000 41.38513  ? 896 HOH F O   1 
HETATM 3677 O O   . HOH F 4 .   ? 171.51600 334.64000 39.16600  1.000 49.79975  ? 897 HOH F O   1 
HETATM 3678 O O   . HOH F 4 .   ? 159.38900 338.55400 40.36700  1.000 40.03216  ? 898 HOH F O   1 
HETATM 3679 O O   . HOH F 4 .   ? 179.17800 369.09100 37.81400  1.000 43.05574  ? 899 HOH F O   1 
HETATM 3680 O O   . HOH F 4 .   ? 170.15900 356.23100 20.09400  1.000 48.92831  ? 900 HOH F O   1 
HETATM 3681 O O   . HOH F 4 .   ? 177.54800 355.12100 43.51100  1.000 35.02378  ? 901 HOH F O   1 
HETATM 3682 O O   . HOH F 4 .   ? 188.39100 348.96700 20.39400  1.000 48.88108  ? 902 HOH F O   1 
HETATM 3683 O O   . HOH F 4 .   ? 170.70600 336.60100 37.35600  1.000 34.25873  ? 903 HOH F O   1 
# 
