data_8W3G
# 
_entry.id   8W3G 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W3G         pdb_00008w3g 10.2210/pdb8w3g/pdb 
WWPDB D_1000280343 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W3G 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jiang@scripps.edu 
_pdbx_contact_author.name_first         JIANG 
_pdbx_contact_author.name_last          ZHU 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0259-7157 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lee, Y.Z.'       1 ? 
'Stanfield, R.L.' 2 ? 
'Wilson, I.A.'    3 ? 
'Zhu, J.'         4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9939 
_citation.page_last                 9939 
_citation.title                     
'Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54287-x 
_citation.pdbx_database_id_PubMed   39550381 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lee, Y.Z.'       1  0000-0002-5651-863X 
primary 'Han, J.'         2  ?                   
primary 'Zhang, Y.N.'     3  0000-0001-9053-5890 
primary 'Ward, G.'        4  ?                   
primary 'Braz Gomes, K.'  5  ?                   
primary 'Auclair, S.'     6  ?                   
primary 'Stanfield, R.L.' 7  ?                   
primary 'He, L.'          8  ?                   
primary 'Wilson, I.A.'    9  0000-0002-6469-2419 
primary 'Zhu, J.'         10 0000-0003-0259-7157 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Prefusion-stabilized RSV F protein UFCR1(1TD0)' 70700.328 1  ? ? ? ? 
2 non-polymer syn 1,2-ETHANEDIOL                                   62.068    1  ? ? ? ? 
3 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose         221.208   1  ? ? ? ? 
4 water       nat water                                            18.015    91 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLAS
GGGGSASGDIIKLLNEQVNKEMQSSNLYMSMSSWCYTHSLDGAGLFLFDHAAEEYEHAKKLIIFLNENNVPVQLTSISAP
EHKFEGLTQIFQKAYEHEQHISESINNIVDHAIKSKDHATFNFLQWYVAEQHEEEVLFKDILDKIELIGNENHGLYLAD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLAS
GGGGSASGDIIKLLNEQVNKEMQSSNLYMSMSSWCYTHSLDGAGLFLFDHAAEEYEHAKKLIIFLNENNVPVQLTSISAP
EHKFEGLTQIFQKAYEHEQHISESINNIVDHAIKSKDHATFNFLQWYVAEQHEEEVLFKDILDKIELIGNENHGLYLAD
;
_entity_poly.pdbx_strand_id                 F 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1,2-ETHANEDIOL                           EDO 
3 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
4 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   ILE n 
1 4   LEU n 
1 5   PRO n 
1 6   SER n 
1 7   PRO n 
1 8   GLY n 
1 9   MET n 
1 10  PRO n 
1 11  ALA n 
1 12  LEU n 
1 13  LEU n 
1 14  SER n 
1 15  LEU n 
1 16  VAL n 
1 17  SER n 
1 18  LEU n 
1 19  LEU n 
1 20  SER n 
1 21  VAL n 
1 22  LEU n 
1 23  LEU n 
1 24  MET n 
1 25  GLY n 
1 26  CYS n 
1 27  VAL n 
1 28  ALA n 
1 29  GLU n 
1 30  GLN n 
1 31  ASN n 
1 32  ILE n 
1 33  THR n 
1 34  GLU n 
1 35  GLU n 
1 36  PHE n 
1 37  TYR n 
1 38  GLN n 
1 39  SER n 
1 40  THR n 
1 41  CYS n 
1 42  SER n 
1 43  ALA n 
1 44  VAL n 
1 45  SER n 
1 46  LYS n 
1 47  GLY n 
1 48  TYR n 
1 49  LEU n 
1 50  SER n 
1 51  ALA n 
1 52  LEU n 
1 53  ARG n 
1 54  THR n 
1 55  GLY n 
1 56  TRP n 
1 57  TYR n 
1 58  THR n 
1 59  SER n 
1 60  VAL n 
1 61  ILE n 
1 62  THR n 
1 63  ILE n 
1 64  GLU n 
1 65  LEU n 
1 66  SER n 
1 67  ASN n 
1 68  ILE n 
1 69  LYS n 
1 70  GLU n 
1 71  ASN n 
1 72  LYS n 
1 73  CYS n 
1 74  ASN n 
1 75  GLY n 
1 76  THR n 
1 77  ASP n 
1 78  ALA n 
1 79  LYS n 
1 80  VAL n 
1 81  LYS n 
1 82  LEU n 
1 83  ILE n 
1 84  LYS n 
1 85  GLN n 
1 86  GLU n 
1 87  LEU n 
1 88  ASP n 
1 89  LYS n 
1 90  TYR n 
1 91  LYS n 
1 92  ASN n 
1 93  ALA n 
1 94  VAL n 
1 95  THR n 
1 96  ASP n 
1 97  LEU n 
1 98  GLN n 
1 99  LEU n 
1 100 LEU n 
1 101 MET n 
1 102 GLN n 
1 103 SER n 
1 104 THR n 
1 105 PRO n 
1 106 ALA n 
1 107 THR n 
1 108 GLY n 
1 109 SER n 
1 110 GLY n 
1 111 SER n 
1 112 ALA n 
1 113 ILE n 
1 114 ALA n 
1 115 SER n 
1 116 GLY n 
1 117 VAL n 
1 118 ALA n 
1 119 VAL n 
1 120 CYS n 
1 121 LYS n 
1 122 VAL n 
1 123 LEU n 
1 124 HIS n 
1 125 LEU n 
1 126 GLU n 
1 127 GLY n 
1 128 GLU n 
1 129 VAL n 
1 130 ASN n 
1 131 LYS n 
1 132 ILE n 
1 133 LYS n 
1 134 SER n 
1 135 ALA n 
1 136 LEU n 
1 137 LEU n 
1 138 SER n 
1 139 THR n 
1 140 ASN n 
1 141 LYS n 
1 142 ALA n 
1 143 VAL n 
1 144 VAL n 
1 145 SER n 
1 146 LEU n 
1 147 SER n 
1 148 ASN n 
1 149 GLY n 
1 150 VAL n 
1 151 SER n 
1 152 VAL n 
1 153 LEU n 
1 154 THR n 
1 155 SER n 
1 156 LYS n 
1 157 VAL n 
1 158 LEU n 
1 159 ASP n 
1 160 LEU n 
1 161 LYS n 
1 162 ASN n 
1 163 TYR n 
1 164 ILE n 
1 165 ASP n 
1 166 LYS n 
1 167 GLN n 
1 168 LEU n 
1 169 LEU n 
1 170 PRO n 
1 171 ILE n 
1 172 VAL n 
1 173 ASN n 
1 174 LYS n 
1 175 GLN n 
1 176 SER n 
1 177 CYS n 
1 178 SER n 
1 179 ILE n 
1 180 PRO n 
1 181 ASN n 
1 182 ILE n 
1 183 GLU n 
1 184 THR n 
1 185 VAL n 
1 186 ILE n 
1 187 GLU n 
1 188 PHE n 
1 189 GLN n 
1 190 GLN n 
1 191 LYS n 
1 192 ASN n 
1 193 ASN n 
1 194 ARG n 
1 195 LEU n 
1 196 LEU n 
1 197 GLU n 
1 198 ILE n 
1 199 THR n 
1 200 ARG n 
1 201 GLU n 
1 202 PHE n 
1 203 SER n 
1 204 VAL n 
1 205 ASN n 
1 206 ALA n 
1 207 GLY n 
1 208 VAL n 
1 209 THR n 
1 210 THR n 
1 211 PRO n 
1 212 VAL n 
1 213 SER n 
1 214 THR n 
1 215 TYR n 
1 216 MET n 
1 217 LEU n 
1 218 THR n 
1 219 ASN n 
1 220 SER n 
1 221 GLU n 
1 222 LEU n 
1 223 LEU n 
1 224 SER n 
1 225 LEU n 
1 226 ILE n 
1 227 ASN n 
1 228 ASP n 
1 229 MET n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 ASN n 
1 234 ASP n 
1 235 GLN n 
1 236 LYS n 
1 237 LYS n 
1 238 LEU n 
1 239 MET n 
1 240 SER n 
1 241 ASN n 
1 242 ASN n 
1 243 VAL n 
1 244 GLN n 
1 245 ILE n 
1 246 VAL n 
1 247 ARG n 
1 248 GLN n 
1 249 GLN n 
1 250 SER n 
1 251 TYR n 
1 252 SER n 
1 253 ILE n 
1 254 MET n 
1 255 CYS n 
1 256 ILE n 
1 257 ILE n 
1 258 LYS n 
1 259 GLU n 
1 260 GLU n 
1 261 VAL n 
1 262 LEU n 
1 263 ALA n 
1 264 TYR n 
1 265 VAL n 
1 266 VAL n 
1 267 GLN n 
1 268 LEU n 
1 269 PRO n 
1 270 LEU n 
1 271 TYR n 
1 272 GLY n 
1 273 VAL n 
1 274 ILE n 
1 275 ASP n 
1 276 THR n 
1 277 PRO n 
1 278 CYS n 
1 279 TRP n 
1 280 LYS n 
1 281 LEU n 
1 282 HIS n 
1 283 THR n 
1 284 SER n 
1 285 PRO n 
1 286 LEU n 
1 287 CYS n 
1 288 THR n 
1 289 THR n 
1 290 ASN n 
1 291 THR n 
1 292 LYS n 
1 293 GLU n 
1 294 GLY n 
1 295 SER n 
1 296 ASN n 
1 297 ILE n 
1 298 CYS n 
1 299 LEU n 
1 300 THR n 
1 301 ARG n 
1 302 THR n 
1 303 ASP n 
1 304 ARG n 
1 305 GLY n 
1 306 TRP n 
1 307 TYR n 
1 308 CYS n 
1 309 ASP n 
1 310 ASN n 
1 311 ALA n 
1 312 GLY n 
1 313 SER n 
1 314 VAL n 
1 315 SER n 
1 316 PHE n 
1 317 PHE n 
1 318 PRO n 
1 319 GLN n 
1 320 ALA n 
1 321 GLU n 
1 322 THR n 
1 323 CYS n 
1 324 LYS n 
1 325 VAL n 
1 326 GLN n 
1 327 SER n 
1 328 ASN n 
1 329 ARG n 
1 330 VAL n 
1 331 PHE n 
1 332 CYS n 
1 333 ASP n 
1 334 THR n 
1 335 MET n 
1 336 ASN n 
1 337 SER n 
1 338 LEU n 
1 339 THR n 
1 340 LEU n 
1 341 PRO n 
1 342 SER n 
1 343 GLU n 
1 344 VAL n 
1 345 ASN n 
1 346 LEU n 
1 347 CYS n 
1 348 ASN n 
1 349 VAL n 
1 350 ASP n 
1 351 ILE n 
1 352 PHE n 
1 353 ASN n 
1 354 PRO n 
1 355 LYS n 
1 356 TYR n 
1 357 ASP n 
1 358 CYS n 
1 359 LYS n 
1 360 ILE n 
1 361 MET n 
1 362 THR n 
1 363 SER n 
1 364 LYS n 
1 365 THR n 
1 366 ASP n 
1 367 VAL n 
1 368 SER n 
1 369 SER n 
1 370 SER n 
1 371 VAL n 
1 372 ILE n 
1 373 THR n 
1 374 SER n 
1 375 LEU n 
1 376 GLY n 
1 377 ALA n 
1 378 ILE n 
1 379 VAL n 
1 380 SER n 
1 381 CYS n 
1 382 TYR n 
1 383 GLY n 
1 384 LYS n 
1 385 THR n 
1 386 LYS n 
1 387 CYS n 
1 388 THR n 
1 389 ALA n 
1 390 SER n 
1 391 ASN n 
1 392 LYS n 
1 393 ASN n 
1 394 ARG n 
1 395 GLY n 
1 396 ILE n 
1 397 ILE n 
1 398 LYS n 
1 399 THR n 
1 400 PHE n 
1 401 SER n 
1 402 ASN n 
1 403 GLY n 
1 404 CYS n 
1 405 ASP n 
1 406 TYR n 
1 407 VAL n 
1 408 SER n 
1 409 ASN n 
1 410 LYS n 
1 411 GLY n 
1 412 VAL n 
1 413 ASP n 
1 414 THR n 
1 415 VAL n 
1 416 SER n 
1 417 VAL n 
1 418 GLY n 
1 419 ASN n 
1 420 THR n 
1 421 LEU n 
1 422 TYR n 
1 423 TYR n 
1 424 VAL n 
1 425 ASN n 
1 426 LYS n 
1 427 GLN n 
1 428 GLU n 
1 429 GLY n 
1 430 LYS n 
1 431 SER n 
1 432 LEU n 
1 433 TYR n 
1 434 VAL n 
1 435 LYS n 
1 436 GLY n 
1 437 GLU n 
1 438 PRO n 
1 439 ILE n 
1 440 ILE n 
1 441 ASN n 
1 442 PHE n 
1 443 TYR n 
1 444 ASP n 
1 445 PRO n 
1 446 LEU n 
1 447 VAL n 
1 448 PHE n 
1 449 PRO n 
1 450 SER n 
1 451 ASP n 
1 452 GLU n 
1 453 PHE n 
1 454 ASP n 
1 455 ALA n 
1 456 SER n 
1 457 ILE n 
1 458 SER n 
1 459 GLN n 
1 460 VAL n 
1 461 ASN n 
1 462 GLU n 
1 463 LYS n 
1 464 ILE n 
1 465 ASN n 
1 466 GLN n 
1 467 SER n 
1 468 LEU n 
1 469 ALA n 
1 470 PHE n 
1 471 ILE n 
1 472 ARG n 
1 473 LYS n 
1 474 SER n 
1 475 ASP n 
1 476 GLU n 
1 477 LEU n 
1 478 LEU n 
1 479 ALA n 
1 480 SER n 
1 481 GLY n 
1 482 GLY n 
1 483 GLY n 
1 484 GLY n 
1 485 SER n 
1 486 ALA n 
1 487 SER n 
1 488 GLY n 
1 489 ASP n 
1 490 ILE n 
1 491 ILE n 
1 492 LYS n 
1 493 LEU n 
1 494 LEU n 
1 495 ASN n 
1 496 GLU n 
1 497 GLN n 
1 498 VAL n 
1 499 ASN n 
1 500 LYS n 
1 501 GLU n 
1 502 MET n 
1 503 GLN n 
1 504 SER n 
1 505 SER n 
1 506 ASN n 
1 507 LEU n 
1 508 TYR n 
1 509 MET n 
1 510 SER n 
1 511 MET n 
1 512 SER n 
1 513 SER n 
1 514 TRP n 
1 515 CYS n 
1 516 TYR n 
1 517 THR n 
1 518 HIS n 
1 519 SER n 
1 520 LEU n 
1 521 ASP n 
1 522 GLY n 
1 523 ALA n 
1 524 GLY n 
1 525 LEU n 
1 526 PHE n 
1 527 LEU n 
1 528 PHE n 
1 529 ASP n 
1 530 HIS n 
1 531 ALA n 
1 532 ALA n 
1 533 GLU n 
1 534 GLU n 
1 535 TYR n 
1 536 GLU n 
1 537 HIS n 
1 538 ALA n 
1 539 LYS n 
1 540 LYS n 
1 541 LEU n 
1 542 ILE n 
1 543 ILE n 
1 544 PHE n 
1 545 LEU n 
1 546 ASN n 
1 547 GLU n 
1 548 ASN n 
1 549 ASN n 
1 550 VAL n 
1 551 PRO n 
1 552 VAL n 
1 553 GLN n 
1 554 LEU n 
1 555 THR n 
1 556 SER n 
1 557 ILE n 
1 558 SER n 
1 559 ALA n 
1 560 PRO n 
1 561 GLU n 
1 562 HIS n 
1 563 LYS n 
1 564 PHE n 
1 565 GLU n 
1 566 GLY n 
1 567 LEU n 
1 568 THR n 
1 569 GLN n 
1 570 ILE n 
1 571 PHE n 
1 572 GLN n 
1 573 LYS n 
1 574 ALA n 
1 575 TYR n 
1 576 GLU n 
1 577 HIS n 
1 578 GLU n 
1 579 GLN n 
1 580 HIS n 
1 581 ILE n 
1 582 SER n 
1 583 GLU n 
1 584 SER n 
1 585 ILE n 
1 586 ASN n 
1 587 ASN n 
1 588 ILE n 
1 589 VAL n 
1 590 ASP n 
1 591 HIS n 
1 592 ALA n 
1 593 ILE n 
1 594 LYS n 
1 595 SER n 
1 596 LYS n 
1 597 ASP n 
1 598 HIS n 
1 599 ALA n 
1 600 THR n 
1 601 PHE n 
1 602 ASN n 
1 603 PHE n 
1 604 LEU n 
1 605 GLN n 
1 606 TRP n 
1 607 TYR n 
1 608 VAL n 
1 609 ALA n 
1 610 GLU n 
1 611 GLN n 
1 612 HIS n 
1 613 GLU n 
1 614 GLU n 
1 615 GLU n 
1 616 VAL n 
1 617 LEU n 
1 618 PHE n 
1 619 LYS n 
1 620 ASP n 
1 621 ILE n 
1 622 LEU n 
1 623 ASP n 
1 624 LYS n 
1 625 ILE n 
1 626 GLU n 
1 627 LEU n 
1 628 ILE n 
1 629 GLY n 
1 630 ASN n 
1 631 GLU n 
1 632 ASN n 
1 633 HIS n 
1 634 GLY n 
1 635 LEU n 
1 636 TYR n 
1 637 LEU n 
1 638 ALA n 
1 639 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   639 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Human respiratory syncytial virus A2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11259 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
EDO non-polymer                  . 1,2-ETHANEDIOL                           'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -3  ?   ?   ?   F . n 
A 1 2   GLY 2   -2  ?   ?   ?   F . n 
A 1 3   ILE 3   -1  ?   ?   ?   F . n 
A 1 4   LEU 4   0   ?   ?   ?   F . n 
A 1 5   PRO 5   1   ?   ?   ?   F . n 
A 1 6   SER 6   2   ?   ?   ?   F . n 
A 1 7   PRO 7   3   ?   ?   ?   F . n 
A 1 8   GLY 8   4   ?   ?   ?   F . n 
A 1 9   MET 9   5   ?   ?   ?   F . n 
A 1 10  PRO 10  6   ?   ?   ?   F . n 
A 1 11  ALA 11  7   ?   ?   ?   F . n 
A 1 12  LEU 12  8   ?   ?   ?   F . n 
A 1 13  LEU 13  9   ?   ?   ?   F . n 
A 1 14  SER 14  10  ?   ?   ?   F . n 
A 1 15  LEU 15  11  ?   ?   ?   F . n 
A 1 16  VAL 16  12  ?   ?   ?   F . n 
A 1 17  SER 17  13  ?   ?   ?   F . n 
A 1 18  LEU 18  14  ?   ?   ?   F . n 
A 1 19  LEU 19  15  ?   ?   ?   F . n 
A 1 20  SER 20  16  ?   ?   ?   F . n 
A 1 21  VAL 21  17  ?   ?   ?   F . n 
A 1 22  LEU 22  18  ?   ?   ?   F . n 
A 1 23  LEU 23  19  ?   ?   ?   F . n 
A 1 24  MET 24  20  ?   ?   ?   F . n 
A 1 25  GLY 25  21  ?   ?   ?   F . n 
A 1 26  CYS 26  22  ?   ?   ?   F . n 
A 1 27  VAL 27  23  ?   ?   ?   F . n 
A 1 28  ALA 28  24  ?   ?   ?   F . n 
A 1 29  GLU 29  25  ?   ?   ?   F . n 
A 1 30  GLN 30  26  26  GLN GLN F . n 
A 1 31  ASN 31  27  27  ASN ASN F . n 
A 1 32  ILE 32  28  28  ILE ILE F . n 
A 1 33  THR 33  29  29  THR THR F . n 
A 1 34  GLU 34  30  30  GLU GLU F . n 
A 1 35  GLU 35  31  31  GLU GLU F . n 
A 1 36  PHE 36  32  32  PHE PHE F . n 
A 1 37  TYR 37  33  33  TYR TYR F . n 
A 1 38  GLN 38  34  34  GLN GLN F . n 
A 1 39  SER 39  35  35  SER SER F . n 
A 1 40  THR 40  36  36  THR THR F . n 
A 1 41  CYS 41  37  37  CYS CYS F . n 
A 1 42  SER 42  38  38  SER SER F . n 
A 1 43  ALA 43  39  39  ALA ALA F . n 
A 1 44  VAL 44  40  40  VAL VAL F . n 
A 1 45  SER 45  41  41  SER SER F . n 
A 1 46  LYS 46  42  42  LYS LYS F . n 
A 1 47  GLY 47  43  43  GLY GLY F . n 
A 1 48  TYR 48  44  44  TYR TYR F . n 
A 1 49  LEU 49  45  45  LEU LEU F . n 
A 1 50  SER 50  46  46  SER SER F . n 
A 1 51  ALA 51  47  47  ALA ALA F . n 
A 1 52  LEU 52  48  48  LEU LEU F . n 
A 1 53  ARG 53  49  49  ARG ARG F . n 
A 1 54  THR 54  50  50  THR THR F . n 
A 1 55  GLY 55  51  51  GLY GLY F . n 
A 1 56  TRP 56  52  52  TRP TRP F . n 
A 1 57  TYR 57  53  53  TYR TYR F . n 
A 1 58  THR 58  54  54  THR THR F . n 
A 1 59  SER 59  55  55  SER SER F . n 
A 1 60  VAL 60  56  56  VAL VAL F . n 
A 1 61  ILE 61  57  57  ILE ILE F . n 
A 1 62  THR 62  58  58  THR THR F . n 
A 1 63  ILE 63  59  59  ILE ILE F . n 
A 1 64  GLU 64  60  60  GLU GLU F . n 
A 1 65  LEU 65  61  61  LEU LEU F . n 
A 1 66  SER 66  62  62  SER SER F . n 
A 1 67  ASN 67  63  63  ASN ASN F . n 
A 1 68  ILE 68  64  64  ILE ILE F . n 
A 1 69  LYS 69  65  65  LYS LYS F . n 
A 1 70  GLU 70  66  66  GLU GLU F . n 
A 1 71  ASN 71  67  67  ASN ASN F . n 
A 1 72  LYS 72  68  68  LYS LYS F . n 
A 1 73  CYS 73  69  69  CYS CYS F . n 
A 1 74  ASN 74  70  70  ASN ASN F . n 
A 1 75  GLY 75  71  71  GLY GLY F . n 
A 1 76  THR 76  72  72  THR THR F . n 
A 1 77  ASP 77  73  73  ASP ASP F . n 
A 1 78  ALA 78  74  74  ALA ALA F . n 
A 1 79  LYS 79  75  75  LYS LYS F . n 
A 1 80  VAL 80  76  76  VAL VAL F . n 
A 1 81  LYS 81  77  77  LYS LYS F . n 
A 1 82  LEU 82  78  78  LEU LEU F . n 
A 1 83  ILE 83  79  79  ILE ILE F . n 
A 1 84  LYS 84  80  80  LYS LYS F . n 
A 1 85  GLN 85  81  81  GLN GLN F . n 
A 1 86  GLU 86  82  82  GLU GLU F . n 
A 1 87  LEU 87  83  83  LEU LEU F . n 
A 1 88  ASP 88  84  84  ASP ASP F . n 
A 1 89  LYS 89  85  85  LYS LYS F . n 
A 1 90  TYR 90  86  86  TYR TYR F . n 
A 1 91  LYS 91  87  87  LYS LYS F . n 
A 1 92  ASN 92  88  88  ASN ASN F . n 
A 1 93  ALA 93  89  89  ALA ALA F . n 
A 1 94  VAL 94  90  90  VAL VAL F . n 
A 1 95  THR 95  91  91  THR THR F . n 
A 1 96  ASP 96  92  92  ASP ASP F . n 
A 1 97  LEU 97  93  93  LEU LEU F . n 
A 1 98  GLN 98  94  94  GLN GLN F . n 
A 1 99  LEU 99  95  95  LEU LEU F . n 
A 1 100 LEU 100 96  96  LEU LEU F . n 
A 1 101 MET 101 97  97  MET MET F . n 
A 1 102 GLN 102 98  98  GLN GLN F . n 
A 1 103 SER 103 99  99  SER SER F . n 
A 1 104 THR 104 100 100 THR THR F . n 
A 1 105 PRO 105 101 101 PRO PRO F . n 
A 1 106 ALA 106 102 102 ALA ALA F . n 
A 1 107 THR 107 103 103 THR THR F . n 
A 1 108 GLY 108 143 143 GLY GLY F . n 
A 1 109 SER 109 144 144 SER SER F . n 
A 1 110 GLY 110 145 145 GLY GLY F . n 
A 1 111 SER 111 146 146 SER SER F . n 
A 1 112 ALA 112 147 147 ALA ALA F . n 
A 1 113 ILE 113 148 148 ILE ILE F . n 
A 1 114 ALA 114 149 149 ALA ALA F . n 
A 1 115 SER 115 150 150 SER SER F . n 
A 1 116 GLY 116 151 151 GLY GLY F . n 
A 1 117 VAL 117 152 152 VAL VAL F . n 
A 1 118 ALA 118 153 153 ALA ALA F . n 
A 1 119 VAL 119 154 154 VAL VAL F . n 
A 1 120 CYS 120 155 155 CYS CYS F . n 
A 1 121 LYS 121 156 156 LYS LYS F . n 
A 1 122 VAL 122 157 157 VAL VAL F . n 
A 1 123 LEU 123 158 158 LEU LEU F . n 
A 1 124 HIS 124 159 159 HIS HIS F . n 
A 1 125 LEU 125 160 160 LEU LEU F . n 
A 1 126 GLU 126 161 161 GLU GLU F . n 
A 1 127 GLY 127 162 162 GLY GLY F . n 
A 1 128 GLU 128 163 163 GLU GLU F . n 
A 1 129 VAL 129 164 164 VAL VAL F . n 
A 1 130 ASN 130 165 165 ASN ASN F . n 
A 1 131 LYS 131 166 166 LYS LYS F . n 
A 1 132 ILE 132 167 167 ILE ILE F . n 
A 1 133 LYS 133 168 168 LYS LYS F . n 
A 1 134 SER 134 169 169 SER SER F . n 
A 1 135 ALA 135 170 170 ALA ALA F . n 
A 1 136 LEU 136 171 171 LEU LEU F . n 
A 1 137 LEU 137 172 172 LEU LEU F . n 
A 1 138 SER 138 173 173 SER SER F . n 
A 1 139 THR 139 174 174 THR THR F . n 
A 1 140 ASN 140 175 175 ASN ASN F . n 
A 1 141 LYS 141 176 176 LYS LYS F . n 
A 1 142 ALA 142 177 177 ALA ALA F . n 
A 1 143 VAL 143 178 178 VAL VAL F . n 
A 1 144 VAL 144 179 179 VAL VAL F . n 
A 1 145 SER 145 180 180 SER SER F . n 
A 1 146 LEU 146 181 181 LEU LEU F . n 
A 1 147 SER 147 182 182 SER SER F . n 
A 1 148 ASN 148 183 183 ASN ASN F . n 
A 1 149 GLY 149 184 184 GLY GLY F . n 
A 1 150 VAL 150 185 185 VAL VAL F . n 
A 1 151 SER 151 186 186 SER SER F . n 
A 1 152 VAL 152 187 187 VAL VAL F . n 
A 1 153 LEU 153 188 188 LEU LEU F . n 
A 1 154 THR 154 189 189 THR THR F . n 
A 1 155 SER 155 190 190 SER SER F . n 
A 1 156 LYS 156 191 191 LYS LYS F . n 
A 1 157 VAL 157 192 192 VAL VAL F . n 
A 1 158 LEU 158 193 193 LEU LEU F . n 
A 1 159 ASP 159 194 194 ASP ASP F . n 
A 1 160 LEU 160 195 195 LEU LEU F . n 
A 1 161 LYS 161 196 196 LYS LYS F . n 
A 1 162 ASN 162 197 197 ASN ASN F . n 
A 1 163 TYR 163 198 198 TYR TYR F . n 
A 1 164 ILE 164 199 199 ILE ILE F . n 
A 1 165 ASP 165 200 200 ASP ASP F . n 
A 1 166 LYS 166 201 201 LYS LYS F . n 
A 1 167 GLN 167 202 202 GLN GLN F . n 
A 1 168 LEU 168 203 203 LEU LEU F . n 
A 1 169 LEU 169 204 204 LEU LEU F . n 
A 1 170 PRO 170 205 205 PRO PRO F . n 
A 1 171 ILE 171 206 206 ILE ILE F . n 
A 1 172 VAL 172 207 207 VAL VAL F . n 
A 1 173 ASN 173 208 208 ASN ASN F . n 
A 1 174 LYS 174 209 209 LYS LYS F . n 
A 1 175 GLN 175 210 210 GLN GLN F . n 
A 1 176 SER 176 211 211 SER SER F . n 
A 1 177 CYS 177 212 212 CYS CYS F . n 
A 1 178 SER 178 213 213 SER SER F . n 
A 1 179 ILE 179 214 214 ILE ILE F . n 
A 1 180 PRO 180 215 215 PRO PRO F . n 
A 1 181 ASN 181 216 216 ASN ASN F . n 
A 1 182 ILE 182 217 217 ILE ILE F . n 
A 1 183 GLU 183 218 218 GLU GLU F . n 
A 1 184 THR 184 219 219 THR THR F . n 
A 1 185 VAL 185 220 220 VAL VAL F . n 
A 1 186 ILE 186 221 221 ILE ILE F . n 
A 1 187 GLU 187 222 222 GLU GLU F . n 
A 1 188 PHE 188 223 223 PHE PHE F . n 
A 1 189 GLN 189 224 224 GLN GLN F . n 
A 1 190 GLN 190 225 225 GLN GLN F . n 
A 1 191 LYS 191 226 226 LYS LYS F . n 
A 1 192 ASN 192 227 227 ASN ASN F . n 
A 1 193 ASN 193 228 228 ASN ASN F . n 
A 1 194 ARG 194 229 229 ARG ARG F . n 
A 1 195 LEU 195 230 230 LEU LEU F . n 
A 1 196 LEU 196 231 231 LEU LEU F . n 
A 1 197 GLU 197 232 232 GLU GLU F . n 
A 1 198 ILE 198 233 233 ILE ILE F . n 
A 1 199 THR 199 234 234 THR THR F . n 
A 1 200 ARG 200 235 235 ARG ARG F . n 
A 1 201 GLU 201 236 236 GLU GLU F . n 
A 1 202 PHE 202 237 237 PHE PHE F . n 
A 1 203 SER 203 238 238 SER SER F . n 
A 1 204 VAL 204 239 239 VAL VAL F . n 
A 1 205 ASN 205 240 240 ASN ASN F . n 
A 1 206 ALA 206 241 241 ALA ALA F . n 
A 1 207 GLY 207 242 242 GLY GLY F . n 
A 1 208 VAL 208 243 243 VAL VAL F . n 
A 1 209 THR 209 244 244 THR THR F . n 
A 1 210 THR 210 245 245 THR THR F . n 
A 1 211 PRO 211 246 246 PRO PRO F . n 
A 1 212 VAL 212 247 247 VAL VAL F . n 
A 1 213 SER 213 248 248 SER SER F . n 
A 1 214 THR 214 249 249 THR THR F . n 
A 1 215 TYR 215 250 250 TYR TYR F . n 
A 1 216 MET 216 251 251 MET MET F . n 
A 1 217 LEU 217 252 252 LEU LEU F . n 
A 1 218 THR 218 253 253 THR THR F . n 
A 1 219 ASN 219 254 254 ASN ASN F . n 
A 1 220 SER 220 255 255 SER SER F . n 
A 1 221 GLU 221 256 256 GLU GLU F . n 
A 1 222 LEU 222 257 257 LEU LEU F . n 
A 1 223 LEU 223 258 258 LEU LEU F . n 
A 1 224 SER 224 259 259 SER SER F . n 
A 1 225 LEU 225 260 260 LEU LEU F . n 
A 1 226 ILE 226 261 261 ILE ILE F . n 
A 1 227 ASN 227 262 262 ASN ASN F . n 
A 1 228 ASP 228 263 263 ASP ASP F . n 
A 1 229 MET 229 264 264 MET MET F . n 
A 1 230 PRO 230 265 265 PRO PRO F . n 
A 1 231 ILE 231 266 266 ILE ILE F . n 
A 1 232 THR 232 267 267 THR THR F . n 
A 1 233 ASN 233 268 268 ASN ASN F . n 
A 1 234 ASP 234 269 269 ASP ASP F . n 
A 1 235 GLN 235 270 270 GLN GLN F . n 
A 1 236 LYS 236 271 271 LYS LYS F . n 
A 1 237 LYS 237 272 272 LYS LYS F . n 
A 1 238 LEU 238 273 273 LEU LEU F . n 
A 1 239 MET 239 274 274 MET MET F . n 
A 1 240 SER 240 275 275 SER SER F . n 
A 1 241 ASN 241 276 276 ASN ASN F . n 
A 1 242 ASN 242 277 277 ASN ASN F . n 
A 1 243 VAL 243 278 278 VAL VAL F . n 
A 1 244 GLN 244 279 279 GLN GLN F . n 
A 1 245 ILE 245 280 280 ILE ILE F . n 
A 1 246 VAL 246 281 281 VAL VAL F . n 
A 1 247 ARG 247 282 282 ARG ARG F . n 
A 1 248 GLN 248 283 283 GLN GLN F . n 
A 1 249 GLN 249 284 284 GLN GLN F . n 
A 1 250 SER 250 285 285 SER SER F . n 
A 1 251 TYR 251 286 286 TYR TYR F . n 
A 1 252 SER 252 287 287 SER SER F . n 
A 1 253 ILE 253 288 288 ILE ILE F . n 
A 1 254 MET 254 289 289 MET MET F . n 
A 1 255 CYS 255 290 290 CYS CYS F . n 
A 1 256 ILE 256 291 291 ILE ILE F . n 
A 1 257 ILE 257 292 292 ILE ILE F . n 
A 1 258 LYS 258 293 293 LYS LYS F . n 
A 1 259 GLU 259 294 294 GLU GLU F . n 
A 1 260 GLU 260 295 295 GLU GLU F . n 
A 1 261 VAL 261 296 296 VAL VAL F . n 
A 1 262 LEU 262 297 297 LEU LEU F . n 
A 1 263 ALA 263 298 298 ALA ALA F . n 
A 1 264 TYR 264 299 299 TYR TYR F . n 
A 1 265 VAL 265 300 300 VAL VAL F . n 
A 1 266 VAL 266 301 301 VAL VAL F . n 
A 1 267 GLN 267 302 302 GLN GLN F . n 
A 1 268 LEU 268 303 303 LEU LEU F . n 
A 1 269 PRO 269 304 304 PRO PRO F . n 
A 1 270 LEU 270 305 305 LEU LEU F . n 
A 1 271 TYR 271 306 306 TYR TYR F . n 
A 1 272 GLY 272 307 307 GLY GLY F . n 
A 1 273 VAL 273 308 308 VAL VAL F . n 
A 1 274 ILE 274 309 309 ILE ILE F . n 
A 1 275 ASP 275 310 310 ASP ASP F . n 
A 1 276 THR 276 311 311 THR THR F . n 
A 1 277 PRO 277 312 312 PRO PRO F . n 
A 1 278 CYS 278 313 313 CYS CYS F . n 
A 1 279 TRP 279 314 314 TRP TRP F . n 
A 1 280 LYS 280 315 315 LYS LYS F . n 
A 1 281 LEU 281 316 316 LEU LEU F . n 
A 1 282 HIS 282 317 317 HIS HIS F . n 
A 1 283 THR 283 318 318 THR THR F . n 
A 1 284 SER 284 319 319 SER SER F . n 
A 1 285 PRO 285 320 320 PRO PRO F . n 
A 1 286 LEU 286 321 321 LEU LEU F . n 
A 1 287 CYS 287 322 322 CYS CYS F . n 
A 1 288 THR 288 323 323 THR THR F . n 
A 1 289 THR 289 324 324 THR THR F . n 
A 1 290 ASN 290 325 325 ASN ASN F . n 
A 1 291 THR 291 326 326 THR THR F . n 
A 1 292 LYS 292 327 327 LYS LYS F . n 
A 1 293 GLU 293 328 328 GLU GLU F . n 
A 1 294 GLY 294 329 329 GLY GLY F . n 
A 1 295 SER 295 330 330 SER SER F . n 
A 1 296 ASN 296 331 331 ASN ASN F . n 
A 1 297 ILE 297 332 332 ILE ILE F . n 
A 1 298 CYS 298 333 333 CYS CYS F . n 
A 1 299 LEU 299 334 334 LEU LEU F . n 
A 1 300 THR 300 335 335 THR THR F . n 
A 1 301 ARG 301 336 336 ARG ARG F . n 
A 1 302 THR 302 337 337 THR THR F . n 
A 1 303 ASP 303 338 338 ASP ASP F . n 
A 1 304 ARG 304 339 339 ARG ARG F . n 
A 1 305 GLY 305 340 340 GLY GLY F . n 
A 1 306 TRP 306 341 341 TRP TRP F . n 
A 1 307 TYR 307 342 342 TYR TYR F . n 
A 1 308 CYS 308 343 343 CYS CYS F . n 
A 1 309 ASP 309 344 344 ASP ASP F . n 
A 1 310 ASN 310 345 345 ASN ASN F . n 
A 1 311 ALA 311 346 346 ALA ALA F . n 
A 1 312 GLY 312 347 347 GLY GLY F . n 
A 1 313 SER 313 348 348 SER SER F . n 
A 1 314 VAL 314 349 349 VAL VAL F . n 
A 1 315 SER 315 350 350 SER SER F . n 
A 1 316 PHE 316 351 351 PHE PHE F . n 
A 1 317 PHE 317 352 352 PHE PHE F . n 
A 1 318 PRO 318 353 353 PRO PRO F . n 
A 1 319 GLN 319 354 354 GLN GLN F . n 
A 1 320 ALA 320 355 355 ALA ALA F . n 
A 1 321 GLU 321 356 356 GLU GLU F . n 
A 1 322 THR 322 357 357 THR THR F . n 
A 1 323 CYS 323 358 358 CYS CYS F . n 
A 1 324 LYS 324 359 359 LYS LYS F . n 
A 1 325 VAL 325 360 360 VAL VAL F . n 
A 1 326 GLN 326 361 361 GLN GLN F . n 
A 1 327 SER 327 362 362 SER SER F . n 
A 1 328 ASN 328 363 363 ASN ASN F . n 
A 1 329 ARG 329 364 364 ARG ARG F . n 
A 1 330 VAL 330 365 365 VAL VAL F . n 
A 1 331 PHE 331 366 366 PHE PHE F . n 
A 1 332 CYS 332 367 367 CYS CYS F . n 
A 1 333 ASP 333 368 368 ASP ASP F . n 
A 1 334 THR 334 369 369 THR THR F . n 
A 1 335 MET 335 370 370 MET MET F . n 
A 1 336 ASN 336 371 371 ASN ASN F . n 
A 1 337 SER 337 372 372 SER SER F . n 
A 1 338 LEU 338 373 373 LEU LEU F . n 
A 1 339 THR 339 374 374 THR THR F . n 
A 1 340 LEU 340 375 375 LEU LEU F . n 
A 1 341 PRO 341 376 376 PRO PRO F . n 
A 1 342 SER 342 377 377 SER SER F . n 
A 1 343 GLU 343 378 378 GLU GLU F . n 
A 1 344 VAL 344 379 379 VAL VAL F . n 
A 1 345 ASN 345 380 380 ASN ASN F . n 
A 1 346 LEU 346 381 381 LEU LEU F . n 
A 1 347 CYS 347 382 382 CYS CYS F . n 
A 1 348 ASN 348 383 383 ASN ASN F . n 
A 1 349 VAL 349 384 384 VAL VAL F . n 
A 1 350 ASP 350 385 385 ASP ASP F . n 
A 1 351 ILE 351 386 386 ILE ILE F . n 
A 1 352 PHE 352 387 387 PHE PHE F . n 
A 1 353 ASN 353 388 388 ASN ASN F . n 
A 1 354 PRO 354 389 389 PRO PRO F . n 
A 1 355 LYS 355 390 390 LYS LYS F . n 
A 1 356 TYR 356 391 391 TYR TYR F . n 
A 1 357 ASP 357 392 392 ASP ASP F . n 
A 1 358 CYS 358 393 393 CYS CYS F . n 
A 1 359 LYS 359 394 394 LYS LYS F . n 
A 1 360 ILE 360 395 395 ILE ILE F . n 
A 1 361 MET 361 396 396 MET MET F . n 
A 1 362 THR 362 397 397 THR THR F . n 
A 1 363 SER 363 398 398 SER SER F . n 
A 1 364 LYS 364 399 399 LYS LYS F . n 
A 1 365 THR 365 400 400 THR THR F . n 
A 1 366 ASP 366 401 401 ASP ASP F . n 
A 1 367 VAL 367 402 402 VAL VAL F . n 
A 1 368 SER 368 403 403 SER SER F . n 
A 1 369 SER 369 404 404 SER SER F . n 
A 1 370 SER 370 405 405 SER SER F . n 
A 1 371 VAL 371 406 406 VAL VAL F . n 
A 1 372 ILE 372 407 407 ILE ILE F . n 
A 1 373 THR 373 408 408 THR THR F . n 
A 1 374 SER 374 409 409 SER SER F . n 
A 1 375 LEU 375 410 410 LEU LEU F . n 
A 1 376 GLY 376 411 411 GLY GLY F . n 
A 1 377 ALA 377 412 412 ALA ALA F . n 
A 1 378 ILE 378 413 413 ILE ILE F . n 
A 1 379 VAL 379 414 414 VAL VAL F . n 
A 1 380 SER 380 415 415 SER SER F . n 
A 1 381 CYS 381 416 416 CYS CYS F . n 
A 1 382 TYR 382 417 417 TYR TYR F . n 
A 1 383 GLY 383 418 418 GLY GLY F . n 
A 1 384 LYS 384 419 419 LYS LYS F . n 
A 1 385 THR 385 420 420 THR THR F . n 
A 1 386 LYS 386 421 421 LYS LYS F . n 
A 1 387 CYS 387 422 422 CYS CYS F . n 
A 1 388 THR 388 423 423 THR THR F . n 
A 1 389 ALA 389 424 424 ALA ALA F . n 
A 1 390 SER 390 425 425 SER SER F . n 
A 1 391 ASN 391 426 426 ASN ASN F . n 
A 1 392 LYS 392 427 427 LYS LYS F . n 
A 1 393 ASN 393 428 428 ASN ASN F . n 
A 1 394 ARG 394 429 429 ARG ARG F . n 
A 1 395 GLY 395 430 430 GLY GLY F . n 
A 1 396 ILE 396 431 431 ILE ILE F . n 
A 1 397 ILE 397 432 432 ILE ILE F . n 
A 1 398 LYS 398 433 433 LYS LYS F . n 
A 1 399 THR 399 434 434 THR THR F . n 
A 1 400 PHE 400 435 435 PHE PHE F . n 
A 1 401 SER 401 436 436 SER SER F . n 
A 1 402 ASN 402 437 437 ASN ASN F . n 
A 1 403 GLY 403 438 438 GLY GLY F . n 
A 1 404 CYS 404 439 439 CYS CYS F . n 
A 1 405 ASP 405 440 440 ASP ASP F . n 
A 1 406 TYR 406 441 441 TYR TYR F . n 
A 1 407 VAL 407 442 442 VAL VAL F . n 
A 1 408 SER 408 443 443 SER SER F . n 
A 1 409 ASN 409 444 444 ASN ASN F . n 
A 1 410 LYS 410 445 445 LYS LYS F . n 
A 1 411 GLY 411 446 446 GLY GLY F . n 
A 1 412 VAL 412 447 447 VAL VAL F . n 
A 1 413 ASP 413 448 448 ASP ASP F . n 
A 1 414 THR 414 449 449 THR THR F . n 
A 1 415 VAL 415 450 450 VAL VAL F . n 
A 1 416 SER 416 451 451 SER SER F . n 
A 1 417 VAL 417 452 452 VAL VAL F . n 
A 1 418 GLY 418 453 453 GLY GLY F . n 
A 1 419 ASN 419 454 454 ASN ASN F . n 
A 1 420 THR 420 455 455 THR THR F . n 
A 1 421 LEU 421 456 456 LEU LEU F . n 
A 1 422 TYR 422 457 457 TYR TYR F . n 
A 1 423 TYR 423 458 458 TYR TYR F . n 
A 1 424 VAL 424 459 459 VAL VAL F . n 
A 1 425 ASN 425 460 460 ASN ASN F . n 
A 1 426 LYS 426 461 461 LYS LYS F . n 
A 1 427 GLN 427 462 462 GLN GLN F . n 
A 1 428 GLU 428 463 463 GLU GLU F . n 
A 1 429 GLY 429 464 464 GLY GLY F . n 
A 1 430 LYS 430 465 465 LYS LYS F . n 
A 1 431 SER 431 466 466 SER SER F . n 
A 1 432 LEU 432 467 467 LEU LEU F . n 
A 1 433 TYR 433 468 468 TYR TYR F . n 
A 1 434 VAL 434 469 469 VAL VAL F . n 
A 1 435 LYS 435 470 470 LYS LYS F . n 
A 1 436 GLY 436 471 471 GLY GLY F . n 
A 1 437 GLU 437 472 472 GLU GLU F . n 
A 1 438 PRO 438 473 473 PRO PRO F . n 
A 1 439 ILE 439 474 474 ILE ILE F . n 
A 1 440 ILE 440 475 475 ILE ILE F . n 
A 1 441 ASN 441 476 476 ASN ASN F . n 
A 1 442 PHE 442 477 477 PHE PHE F . n 
A 1 443 TYR 443 478 478 TYR TYR F . n 
A 1 444 ASP 444 479 479 ASP ASP F . n 
A 1 445 PRO 445 480 480 PRO PRO F . n 
A 1 446 LEU 446 481 481 LEU LEU F . n 
A 1 447 VAL 447 482 482 VAL VAL F . n 
A 1 448 PHE 448 483 483 PHE PHE F . n 
A 1 449 PRO 449 484 484 PRO PRO F . n 
A 1 450 SER 450 485 485 SER SER F . n 
A 1 451 ASP 451 486 486 ASP ASP F . n 
A 1 452 GLU 452 487 487 GLU GLU F . n 
A 1 453 PHE 453 488 488 PHE PHE F . n 
A 1 454 ASP 454 489 489 ASP ASP F . n 
A 1 455 ALA 455 490 490 ALA ALA F . n 
A 1 456 SER 456 491 491 SER SER F . n 
A 1 457 ILE 457 492 492 ILE ILE F . n 
A 1 458 SER 458 493 493 SER SER F . n 
A 1 459 GLN 459 494 494 GLN GLN F . n 
A 1 460 VAL 460 495 495 VAL VAL F . n 
A 1 461 ASN 461 496 496 ASN ASN F . n 
A 1 462 GLU 462 497 497 GLU GLU F . n 
A 1 463 LYS 463 498 498 LYS LYS F . n 
A 1 464 ILE 464 499 499 ILE ILE F . n 
A 1 465 ASN 465 500 500 ASN ASN F . n 
A 1 466 GLN 466 501 501 GLN GLN F . n 
A 1 467 SER 467 502 502 SER SER F . n 
A 1 468 LEU 468 503 503 LEU LEU F . n 
A 1 469 ALA 469 504 504 ALA ALA F . n 
A 1 470 PHE 470 505 505 PHE PHE F . n 
A 1 471 ILE 471 506 506 ILE ILE F . n 
A 1 472 ARG 472 507 507 ARG ARG F . n 
A 1 473 LYS 473 508 508 LYS LYS F . n 
A 1 474 SER 474 509 509 SER SER F . n 
A 1 475 ASP 475 510 ?   ?   ?   F . n 
A 1 476 GLU 476 511 ?   ?   ?   F . n 
A 1 477 LEU 477 512 ?   ?   ?   F . n 
A 1 478 LEU 478 513 ?   ?   ?   F . n 
A 1 479 ALA 479 514 ?   ?   ?   F . n 
A 1 480 SER 480 515 ?   ?   ?   F . n 
A 1 481 GLY 481 516 ?   ?   ?   F . n 
A 1 482 GLY 482 517 ?   ?   ?   F . n 
A 1 483 GLY 483 518 ?   ?   ?   F . n 
A 1 484 GLY 484 519 ?   ?   ?   F . n 
A 1 485 SER 485 520 ?   ?   ?   F . n 
A 1 486 ALA 486 521 ?   ?   ?   F . n 
A 1 487 SER 487 522 ?   ?   ?   F . n 
A 1 488 GLY 488 523 ?   ?   ?   F . n 
A 1 489 ASP 489 524 ?   ?   ?   F . n 
A 1 490 ILE 490 525 ?   ?   ?   F . n 
A 1 491 ILE 491 526 ?   ?   ?   F . n 
A 1 492 LYS 492 527 ?   ?   ?   F . n 
A 1 493 LEU 493 528 ?   ?   ?   F . n 
A 1 494 LEU 494 529 ?   ?   ?   F . n 
A 1 495 ASN 495 530 ?   ?   ?   F . n 
A 1 496 GLU 496 531 ?   ?   ?   F . n 
A 1 497 GLN 497 532 ?   ?   ?   F . n 
A 1 498 VAL 498 533 ?   ?   ?   F . n 
A 1 499 ASN 499 534 ?   ?   ?   F . n 
A 1 500 LYS 500 535 ?   ?   ?   F . n 
A 1 501 GLU 501 536 ?   ?   ?   F . n 
A 1 502 MET 502 537 ?   ?   ?   F . n 
A 1 503 GLN 503 538 ?   ?   ?   F . n 
A 1 504 SER 504 539 ?   ?   ?   F . n 
A 1 505 SER 505 540 ?   ?   ?   F . n 
A 1 506 ASN 506 541 ?   ?   ?   F . n 
A 1 507 LEU 507 542 ?   ?   ?   F . n 
A 1 508 TYR 508 543 ?   ?   ?   F . n 
A 1 509 MET 509 544 ?   ?   ?   F . n 
A 1 510 SER 510 545 ?   ?   ?   F . n 
A 1 511 MET 511 546 ?   ?   ?   F . n 
A 1 512 SER 512 547 ?   ?   ?   F . n 
A 1 513 SER 513 548 ?   ?   ?   F . n 
A 1 514 TRP 514 549 ?   ?   ?   F . n 
A 1 515 CYS 515 550 ?   ?   ?   F . n 
A 1 516 TYR 516 551 ?   ?   ?   F . n 
A 1 517 THR 517 552 ?   ?   ?   F . n 
A 1 518 HIS 518 553 ?   ?   ?   F . n 
A 1 519 SER 519 554 ?   ?   ?   F . n 
A 1 520 LEU 520 555 ?   ?   ?   F . n 
A 1 521 ASP 521 556 ?   ?   ?   F . n 
A 1 522 GLY 522 557 ?   ?   ?   F . n 
A 1 523 ALA 523 558 ?   ?   ?   F . n 
A 1 524 GLY 524 559 ?   ?   ?   F . n 
A 1 525 LEU 525 560 ?   ?   ?   F . n 
A 1 526 PHE 526 561 ?   ?   ?   F . n 
A 1 527 LEU 527 562 ?   ?   ?   F . n 
A 1 528 PHE 528 563 ?   ?   ?   F . n 
A 1 529 ASP 529 564 ?   ?   ?   F . n 
A 1 530 HIS 530 565 ?   ?   ?   F . n 
A 1 531 ALA 531 566 ?   ?   ?   F . n 
A 1 532 ALA 532 567 ?   ?   ?   F . n 
A 1 533 GLU 533 568 ?   ?   ?   F . n 
A 1 534 GLU 534 569 ?   ?   ?   F . n 
A 1 535 TYR 535 570 ?   ?   ?   F . n 
A 1 536 GLU 536 571 ?   ?   ?   F . n 
A 1 537 HIS 537 572 ?   ?   ?   F . n 
A 1 538 ALA 538 573 ?   ?   ?   F . n 
A 1 539 LYS 539 574 ?   ?   ?   F . n 
A 1 540 LYS 540 575 ?   ?   ?   F . n 
A 1 541 LEU 541 576 ?   ?   ?   F . n 
A 1 542 ILE 542 577 ?   ?   ?   F . n 
A 1 543 ILE 543 578 ?   ?   ?   F . n 
A 1 544 PHE 544 579 ?   ?   ?   F . n 
A 1 545 LEU 545 580 ?   ?   ?   F . n 
A 1 546 ASN 546 581 ?   ?   ?   F . n 
A 1 547 GLU 547 582 ?   ?   ?   F . n 
A 1 548 ASN 548 583 ?   ?   ?   F . n 
A 1 549 ASN 549 584 ?   ?   ?   F . n 
A 1 550 VAL 550 585 ?   ?   ?   F . n 
A 1 551 PRO 551 586 ?   ?   ?   F . n 
A 1 552 VAL 552 587 ?   ?   ?   F . n 
A 1 553 GLN 553 588 ?   ?   ?   F . n 
A 1 554 LEU 554 589 ?   ?   ?   F . n 
A 1 555 THR 555 590 ?   ?   ?   F . n 
A 1 556 SER 556 591 ?   ?   ?   F . n 
A 1 557 ILE 557 592 ?   ?   ?   F . n 
A 1 558 SER 558 593 ?   ?   ?   F . n 
A 1 559 ALA 559 594 ?   ?   ?   F . n 
A 1 560 PRO 560 595 ?   ?   ?   F . n 
A 1 561 GLU 561 596 ?   ?   ?   F . n 
A 1 562 HIS 562 597 ?   ?   ?   F . n 
A 1 563 LYS 563 598 ?   ?   ?   F . n 
A 1 564 PHE 564 599 ?   ?   ?   F . n 
A 1 565 GLU 565 600 ?   ?   ?   F . n 
A 1 566 GLY 566 601 ?   ?   ?   F . n 
A 1 567 LEU 567 602 ?   ?   ?   F . n 
A 1 568 THR 568 603 ?   ?   ?   F . n 
A 1 569 GLN 569 604 ?   ?   ?   F . n 
A 1 570 ILE 570 605 ?   ?   ?   F . n 
A 1 571 PHE 571 606 ?   ?   ?   F . n 
A 1 572 GLN 572 607 ?   ?   ?   F . n 
A 1 573 LYS 573 608 ?   ?   ?   F . n 
A 1 574 ALA 574 609 ?   ?   ?   F . n 
A 1 575 TYR 575 610 ?   ?   ?   F . n 
A 1 576 GLU 576 611 ?   ?   ?   F . n 
A 1 577 HIS 577 612 ?   ?   ?   F . n 
A 1 578 GLU 578 613 ?   ?   ?   F . n 
A 1 579 GLN 579 614 ?   ?   ?   F . n 
A 1 580 HIS 580 615 ?   ?   ?   F . n 
A 1 581 ILE 581 616 ?   ?   ?   F . n 
A 1 582 SER 582 617 ?   ?   ?   F . n 
A 1 583 GLU 583 618 ?   ?   ?   F . n 
A 1 584 SER 584 619 ?   ?   ?   F . n 
A 1 585 ILE 585 620 ?   ?   ?   F . n 
A 1 586 ASN 586 621 ?   ?   ?   F . n 
A 1 587 ASN 587 622 ?   ?   ?   F . n 
A 1 588 ILE 588 623 ?   ?   ?   F . n 
A 1 589 VAL 589 624 ?   ?   ?   F . n 
A 1 590 ASP 590 625 ?   ?   ?   F . n 
A 1 591 HIS 591 626 ?   ?   ?   F . n 
A 1 592 ALA 592 627 ?   ?   ?   F . n 
A 1 593 ILE 593 628 ?   ?   ?   F . n 
A 1 594 LYS 594 629 ?   ?   ?   F . n 
A 1 595 SER 595 630 ?   ?   ?   F . n 
A 1 596 LYS 596 631 ?   ?   ?   F . n 
A 1 597 ASP 597 632 ?   ?   ?   F . n 
A 1 598 HIS 598 633 ?   ?   ?   F . n 
A 1 599 ALA 599 634 ?   ?   ?   F . n 
A 1 600 THR 600 635 ?   ?   ?   F . n 
A 1 601 PHE 601 636 ?   ?   ?   F . n 
A 1 602 ASN 602 637 ?   ?   ?   F . n 
A 1 603 PHE 603 638 ?   ?   ?   F . n 
A 1 604 LEU 604 639 ?   ?   ?   F . n 
A 1 605 GLN 605 640 ?   ?   ?   F . n 
A 1 606 TRP 606 641 ?   ?   ?   F . n 
A 1 607 TYR 607 642 ?   ?   ?   F . n 
A 1 608 VAL 608 643 ?   ?   ?   F . n 
A 1 609 ALA 609 644 ?   ?   ?   F . n 
A 1 610 GLU 610 645 ?   ?   ?   F . n 
A 1 611 GLN 611 646 ?   ?   ?   F . n 
A 1 612 HIS 612 647 ?   ?   ?   F . n 
A 1 613 GLU 613 648 ?   ?   ?   F . n 
A 1 614 GLU 614 649 ?   ?   ?   F . n 
A 1 615 GLU 615 650 ?   ?   ?   F . n 
A 1 616 VAL 616 651 ?   ?   ?   F . n 
A 1 617 LEU 617 652 ?   ?   ?   F . n 
A 1 618 PHE 618 653 ?   ?   ?   F . n 
A 1 619 LYS 619 654 ?   ?   ?   F . n 
A 1 620 ASP 620 655 ?   ?   ?   F . n 
A 1 621 ILE 621 656 ?   ?   ?   F . n 
A 1 622 LEU 622 657 ?   ?   ?   F . n 
A 1 623 ASP 623 658 ?   ?   ?   F . n 
A 1 624 LYS 624 659 ?   ?   ?   F . n 
A 1 625 ILE 625 660 ?   ?   ?   F . n 
A 1 626 GLU 626 661 ?   ?   ?   F . n 
A 1 627 LEU 627 662 ?   ?   ?   F . n 
A 1 628 ILE 628 663 ?   ?   ?   F . n 
A 1 629 GLY 629 664 ?   ?   ?   F . n 
A 1 630 ASN 630 665 ?   ?   ?   F . n 
A 1 631 GLU 631 666 ?   ?   ?   F . n 
A 1 632 ASN 632 667 ?   ?   ?   F . n 
A 1 633 HIS 633 668 ?   ?   ?   F . n 
A 1 634 GLY 634 669 ?   ?   ?   F . n 
A 1 635 LEU 635 670 ?   ?   ?   F . n 
A 1 636 TYR 636 671 ?   ?   ?   F . n 
A 1 637 LEU 637 672 ?   ?   ?   F . n 
A 1 638 ALA 638 673 ?   ?   ?   F . n 
A 1 639 ASP 639 674 ?   ?   ?   F . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 EDO 1  701 540 EDO EDO F . 
C 3 NAG 1  702 541 NAG NAG F . 
D 4 HOH 1  801 52  HOH HOH F . 
D 4 HOH 2  802 24  HOH HOH F . 
D 4 HOH 3  803 85  HOH HOH F . 
D 4 HOH 4  804 42  HOH HOH F . 
D 4 HOH 5  805 64  HOH HOH F . 
D 4 HOH 6  806 14  HOH HOH F . 
D 4 HOH 7  807 45  HOH HOH F . 
D 4 HOH 8  808 31  HOH HOH F . 
D 4 HOH 9  809 66  HOH HOH F . 
D 4 HOH 10 810 32  HOH HOH F . 
D 4 HOH 11 811 57  HOH HOH F . 
D 4 HOH 12 812 35  HOH HOH F . 
D 4 HOH 13 813 33  HOH HOH F . 
D 4 HOH 14 814 68  HOH HOH F . 
D 4 HOH 15 815 12  HOH HOH F . 
D 4 HOH 16 816 41  HOH HOH F . 
D 4 HOH 17 817 71  HOH HOH F . 
D 4 HOH 18 818 50  HOH HOH F . 
D 4 HOH 19 819 38  HOH HOH F . 
D 4 HOH 20 820 76  HOH HOH F . 
D 4 HOH 21 821 53  HOH HOH F . 
D 4 HOH 22 822 29  HOH HOH F . 
D 4 HOH 23 823 70  HOH HOH F . 
D 4 HOH 24 824 84  HOH HOH F . 
D 4 HOH 25 825 36  HOH HOH F . 
D 4 HOH 26 826 34  HOH HOH F . 
D 4 HOH 27 827 7   HOH HOH F . 
D 4 HOH 28 828 9   HOH HOH F . 
D 4 HOH 29 829 65  HOH HOH F . 
D 4 HOH 30 830 30  HOH HOH F . 
D 4 HOH 31 831 58  HOH HOH F . 
D 4 HOH 32 832 18  HOH HOH F . 
D 4 HOH 33 833 27  HOH HOH F . 
D 4 HOH 34 834 77  HOH HOH F . 
D 4 HOH 35 835 51  HOH HOH F . 
D 4 HOH 36 836 40  HOH HOH F . 
D 4 HOH 37 837 21  HOH HOH F . 
D 4 HOH 38 838 26  HOH HOH F . 
D 4 HOH 39 839 10  HOH HOH F . 
D 4 HOH 40 840 78  HOH HOH F . 
D 4 HOH 41 841 1   HOH HOH F . 
D 4 HOH 42 842 2   HOH HOH F . 
D 4 HOH 43 843 37  HOH HOH F . 
D 4 HOH 44 844 60  HOH HOH F . 
D 4 HOH 45 845 59  HOH HOH F . 
D 4 HOH 46 846 4   HOH HOH F . 
D 4 HOH 47 847 81  HOH HOH F . 
D 4 HOH 48 848 11  HOH HOH F . 
D 4 HOH 49 849 25  HOH HOH F . 
D 4 HOH 50 850 47  HOH HOH F . 
D 4 HOH 51 851 15  HOH HOH F . 
D 4 HOH 52 852 20  HOH HOH F . 
D 4 HOH 53 853 5   HOH HOH F . 
D 4 HOH 54 854 83  HOH HOH F . 
D 4 HOH 55 855 46  HOH HOH F . 
D 4 HOH 56 856 44  HOH HOH F . 
D 4 HOH 57 857 54  HOH HOH F . 
D 4 HOH 58 858 13  HOH HOH F . 
D 4 HOH 59 859 55  HOH HOH F . 
D 4 HOH 60 860 3   HOH HOH F . 
D 4 HOH 61 861 16  HOH HOH F . 
D 4 HOH 62 862 63  HOH HOH F . 
D 4 HOH 63 863 72  HOH HOH F . 
D 4 HOH 64 864 22  HOH HOH F . 
D 4 HOH 65 865 69  HOH HOH F . 
D 4 HOH 66 866 87  HOH HOH F . 
D 4 HOH 67 867 82  HOH HOH F . 
D 4 HOH 68 868 19  HOH HOH F . 
D 4 HOH 69 869 75  HOH HOH F . 
D 4 HOH 70 870 43  HOH HOH F . 
D 4 HOH 71 871 91  HOH HOH F . 
D 4 HOH 72 872 6   HOH HOH F . 
D 4 HOH 73 873 8   HOH HOH F . 
D 4 HOH 74 874 56  HOH HOH F . 
D 4 HOH 75 875 67  HOH HOH F . 
D 4 HOH 76 876 17  HOH HOH F . 
D 4 HOH 77 877 62  HOH HOH F . 
D 4 HOH 78 878 89  HOH HOH F . 
D 4 HOH 79 879 86  HOH HOH F . 
D 4 HOH 80 880 48  HOH HOH F . 
D 4 HOH 81 881 28  HOH HOH F . 
D 4 HOH 82 882 39  HOH HOH F . 
D 4 HOH 83 883 80  HOH HOH F . 
D 4 HOH 84 884 49  HOH HOH F . 
D 4 HOH 85 885 73  HOH HOH F . 
D 4 HOH 86 886 61  HOH HOH F . 
D 4 HOH 87 887 79  HOH HOH F . 
D 4 HOH 88 888 90  HOH HOH F . 
D 4 HOH 89 889 74  HOH HOH F . 
D 4 HOH 90 890 88  HOH HOH F . 
D 4 HOH 91 891 23  HOH HOH F . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W3G 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     168.824 
_cell.length_a_esd                 ? 
_cell.length_b                     168.824 
_cell.length_b_esd                 ? 
_cell.length_c                     168.824 
_cell.length_c_esd                 ? 
_cell.volume                       4811744.491 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W3G 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                213 
_symmetry.space_group_name_Hall            'P 4bd 2ab 3' 
_symmetry.space_group_name_H-M             'P 41 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8W3G 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.84 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.63 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M tri-Ammonium citrate, 12% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-01-19 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          52.26 
_reflns.entry_id                                       8W3G 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.28 
_reflns.d_resolution_low                               26.69 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     37868 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.37 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                21.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.28 
_reflns_shell.d_res_low                                     2.362 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3611 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.785 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               63.66 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8W3G 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.28 
_refine.ls_d_res_low                             26.69 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     37794 
_refine.ls_number_reflns_R_free                  1879 
_refine.ls_number_reflns_R_work                  35915 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.23 
_refine.ls_percent_reflns_R_free                 4.97 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2247 
_refine.ls_R_factor_R_free                       0.2552 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2230 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 30.1421 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3432 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.28 
_refine_hist.d_res_low                        26.69 
_refine_hist.number_atoms_solvent             91 
_refine_hist.number_atoms_total               3542 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3433 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         18 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0105  ? 3506 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.4827  ? 4754 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0856  ? 577  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0157  ? 599  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.7296 ? 1304 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.28 2.34  . . 140 2543 93.06  . . . . 0.3378 . . . . . . . . . . . 0.3820 
'X-RAY DIFFRACTION' 2.34 2.41  . . 143 2737 100.00 . . . . 0.2904 . . . . . . . . . . . 0.3576 
'X-RAY DIFFRACTION' 2.41 2.49  . . 129 2742 100.00 . . . . 0.2932 . . . . . . . . . . . 0.3782 
'X-RAY DIFFRACTION' 2.49 2.58  . . 153 2709 99.97  . . . . 0.2997 . . . . . . . . . . . 0.3244 
'X-RAY DIFFRACTION' 2.58 2.68  . . 153 2743 99.83  . . . . 0.3034 . . . . . . . . . . . 0.3592 
'X-RAY DIFFRACTION' 2.68 2.80  . . 164 2708 99.79  . . . . 0.2996 . . . . . . . . . . . 0.3137 
'X-RAY DIFFRACTION' 2.80 2.95  . . 139 2773 99.90  . . . . 0.2813 . . . . . . . . . . . 0.3373 
'X-RAY DIFFRACTION' 2.95 3.13  . . 124 2772 99.90  . . . . 0.2621 . . . . . . . . . . . 0.2980 
'X-RAY DIFFRACTION' 3.13 3.37  . . 150 2755 99.73  . . . . 0.2500 . . . . . . . . . . . 0.2753 
'X-RAY DIFFRACTION' 3.37 3.71  . . 147 2756 98.98  . . . . 0.2295 . . . . . . . . . . . 0.2471 
'X-RAY DIFFRACTION' 3.71 4.25  . . 139 2794 99.36  . . . . 0.2067 . . . . . . . . . . . 0.2377 
'X-RAY DIFFRACTION' 4.25 5.34  . . 129 2867 99.87  . . . . 0.1685 . . . . . . . . . . . 0.1822 
'X-RAY DIFFRACTION' 5.34 26.69 . . 169 3016 99.84  . . . . 0.1818 . . . . . . . . . . . 0.2212 
# 
_struct.entry_id                     8W3G 
_struct.title                        'Crystal structure of prefusion-stabilized RSV F protein UFCR1(1TD0)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W3G 
_struct_keywords.text            'Respiratory syncytial virus, glycoprotein, prefusion vaccine, stabilized, viral protein' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8W3G 
_struct_ref.pdbx_db_accession          8W3G 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8W3G 
_struct_ref_seq.pdbx_strand_id                F 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 639 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8W3G 
_struct_ref_seq.db_align_beg                  -3 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  674 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -3 
_struct_ref_seq.pdbx_auth_seq_align_end       674 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 13280 ? 
1 MORE         -8    ? 
1 'SSA (A^2)'  54200 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000 0.0000000000 0.0000000000 0.0000000000    0.0000000000 1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000    
2 'crystal symmetry operation' 5_663 z+1,x+1,y-2 0.0000000000 0.0000000000 1.0000000000 168.8240000000  1.0000000000 0.0000000000 
0.0000000000 168.8240000000 0.0000000000 1.0000000000 0.0000000000 -337.6480000000 
3 'crystal symmetry operation' 9_474 y-1,z+2,x-1 0.0000000000 1.0000000000 0.0000000000 -168.8240000000 0.0000000000 0.0000000000 
1.0000000000 337.6480000000 1.0000000000 0.0000000000 0.0000000000 -168.8240000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 77  ? SER A 103 ? ASP F 73  SER F 99  1 ? 27 
HELX_P HELX_P2  AA2 ILE A 113 ? HIS A 124 ? ILE F 148 HIS F 159 1 ? 12 
HELX_P HELX_P3  AA3 GLY A 127 ? LEU A 136 ? GLY F 162 LEU F 171 1 ? 10 
HELX_P HELX_P4  AA4 LEU A 160 ? LEU A 168 ? LEU F 195 LEU F 203 1 ? 9  
HELX_P HELX_P5  AA5 LEU A 168 ? ASN A 173 ? LEU F 203 ASN F 208 1 ? 6  
HELX_P HELX_P6  AA6 ASN A 181 ? ASN A 205 ? ASN F 216 ASN F 240 1 ? 25 
HELX_P HELX_P7  AA7 THR A 218 ? ASP A 228 ? THR F 253 ASP F 263 1 ? 11 
HELX_P HELX_P8  AA8 THR A 232 ? ASN A 242 ? THR F 267 ASN F 277 1 ? 11 
HELX_P HELX_P9  AA9 ASN A 242 ? GLN A 249 ? ASN F 277 GLN F 284 1 ? 8  
HELX_P HELX_P10 AB1 GLN A 319 ? GLU A 321 ? GLN F 354 GLU F 356 5 ? 3  
HELX_P HELX_P11 AB2 MET A 335 ? SER A 337 ? MET F 370 SER F 372 5 ? 3  
HELX_P HELX_P12 AB3 PRO A 341 ? VAL A 349 ? PRO F 376 VAL F 384 5 ? 9  
HELX_P HELX_P13 AB4 PRO A 438 ? TYR A 443 ? PRO F 473 TYR F 478 5 ? 6  
HELX_P HELX_P14 AB5 ASP A 444 ? PHE A 448 ? ASP F 479 PHE F 483 5 ? 5  
HELX_P HELX_P15 AB6 ILE A 457 ? LYS A 473 ? ILE F 492 LYS F 508 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 41  SG  ? ? ? 1_555 A CYS 404 SG ? ? F CYS 37  F CYS 439 1_555 ? ? ? ? ? ? ? 2.023 ? ?               
disulf2 disulf ?   ? A CYS 73  SG  ? ? ? 1_555 A CYS 177 SG ? ? F CYS 69  F CYS 212 1_555 ? ? ? ? ? ? ? 2.039 ? ?               
disulf3 disulf ?   ? A CYS 120 SG  ? ? ? 1_555 A CYS 255 SG ? ? F CYS 155 F CYS 290 1_555 ? ? ? ? ? ? ? 2.060 ? ?               
disulf4 disulf ?   ? A CYS 278 SG  ? ? ? 1_555 A CYS 308 SG ? ? F CYS 313 F CYS 343 1_555 ? ? ? ? ? ? ? 2.025 ? ?               
disulf5 disulf ?   ? A CYS 287 SG  ? ? ? 1_555 A CYS 298 SG ? ? F CYS 322 F CYS 333 1_555 ? ? ? ? ? ? ? 2.013 ? ?               
disulf6 disulf ?   ? A CYS 323 SG  ? ? ? 1_555 A CYS 332 SG ? ? F CYS 358 F CYS 367 1_555 ? ? ? ? ? ? ? 2.057 ? ?               
disulf7 disulf ?   ? A CYS 347 SG  ? ? ? 1_555 A CYS 358 SG ? ? F CYS 382 F CYS 393 1_555 ? ? ? ? ? ? ? 2.027 ? ?               
disulf8 disulf ?   ? A CYS 381 SG  ? ? ? 1_555 A CYS 387 SG ? ? F CYS 416 F CYS 422 1_555 ? ? ? ? ? ? ? 2.079 ? ?               
covale1 covale one ? A ASN 465 ND2 ? ? ? 1_555 C NAG .   C1 ? ? F ASN 500 F NAG 702 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG C .   ? ASN A 465 ? NAG F 702 ? 1_555 ASN F 500 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 CYS A 41  ? CYS A 404 ? CYS F 37  ? 1_555 CYS F 439 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3 CYS A 73  ? CYS A 177 ? CYS F 69  ? 1_555 CYS F 212 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4 CYS A 120 ? CYS A 255 ? CYS F 155 ? 1_555 CYS F 290 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5 CYS A 278 ? CYS A 308 ? CYS F 313 ? 1_555 CYS F 343 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6 CYS A 287 ? CYS A 298 ? CYS F 322 ? 1_555 CYS F 333 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7 CYS A 323 ? CYS A 332 ? CYS F 358 ? 1_555 CYS F 367 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8 CYS A 347 ? CYS A 358 ? CYS F 382 ? 1_555 CYS F 393 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9 CYS A 381 ? CYS A 387 ? CYS F 416 ? 1_555 CYS F 422 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          THR 
_struct_mon_prot_cis.label_seq_id           210 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           THR 
_struct_mon_prot_cis.auth_seq_id            245 
_struct_mon_prot_cis.auth_asym_id           F 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    211 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     246 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    F 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.62 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 6 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? parallel      
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA1 2 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA1 3 SER A 42  ? ARG A 53  ? SER F 38  ARG F 49  
AA1 4 VAL A 273 ? THR A 283 ? VAL F 308 THR F 318 
AA1 5 GLY A 305 ? ASN A 310 ? GLY F 340 ASN F 345 
AA1 6 SER A 313 ? PHE A 317 ? SER F 348 PHE F 352 
AA1 7 LEU A 338 ? LEU A 340 ? LEU F 373 LEU F 375 
AA2 1 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA2 2 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA2 3 SER A 42  ? ARG A 53  ? SER F 38  ARG F 49  
AA2 4 THR A 33  ? TYR A 37  ? THR F 29  TYR F 33  
AA2 5 LYS A 430 ? VAL A 434 ? LYS F 465 VAL F 469 
AA3 1 LYS A 141 ? SER A 145 ? LYS F 176 SER F 180 
AA3 2 SER A 151 ? ASP A 159 ? SER F 186 ASP F 194 
AA3 3 GLY A 55  ? GLU A 64  ? GLY F 51  GLU F 60  
AA3 4 VAL A 261 ? LEU A 270 ? VAL F 296 LEU F 305 
AA3 5 TYR A 251 ? ILE A 257 ? TYR F 286 ILE F 292 
AA3 6 VAL A 208 ? THR A 209 ? VAL F 243 THR F 244 
AA4 1 LEU A 286 ? CYS A 287 ? LEU F 321 CYS F 322 
AA4 2 CYS A 298 ? ARG A 301 ? CYS F 333 ARG F 336 
AA4 3 LYS A 359 ? SER A 363 ? LYS F 394 SER F 398 
AA4 4 ALA A 455 ? SER A 456 ? ALA F 490 SER F 491 
AA5 1 SER A 369 ? ILE A 372 ? SER F 404 ILE F 407 
AA5 2 GLY A 376 ? CYS A 381 ? GLY F 411 CYS F 416 
AA5 3 GLY A 403 ? SER A 408 ? GLY F 438 SER F 443 
AA6 1 GLY A 395 ? THR A 399 ? GLY F 430 THR F 434 
AA6 2 CYS A 387 ? ASN A 391 ? CYS F 422 ASN F 426 
AA6 3 THR A 414 ? VAL A 417 ? THR F 449 VAL F 452 
AA6 4 THR A 420 ? TYR A 423 ? THR F 455 TYR F 458 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LYS A 324 ? N LYS F 359 O PHE A 331 ? O PHE F 366 
AA1 2 3 O CYS A 332 ? O CYS F 367 N ARG A 53  ? N ARG F 49  
AA1 3 4 N ALA A 43  ? N ALA F 39  O HIS A 282 ? O HIS F 317 
AA1 4 5 N LEU A 281 ? N LEU F 316 O GLY A 305 ? O GLY F 340 
AA1 5 6 N TRP A 306 ? N TRP F 341 O PHE A 317 ? O PHE F 352 
AA1 6 7 N VAL A 314 ? N VAL F 349 O LEU A 340 ? O LEU F 375 
AA2 1 2 N LYS A 324 ? N LYS F 359 O PHE A 331 ? O PHE F 366 
AA2 2 3 O CYS A 332 ? O CYS F 367 N ARG A 53  ? N ARG F 49  
AA2 3 4 O SER A 42  ? O SER F 38  N TYR A 37  ? N TYR F 33  
AA2 4 5 N PHE A 36  ? N PHE F 32  O VAL A 434 ? O VAL F 469 
AA3 1 2 N VAL A 144 ? N VAL F 179 O VAL A 152 ? O VAL F 187 
AA3 2 3 O SER A 155 ? O SER F 190 N THR A 62  ? N THR F 58  
AA3 3 4 N ILE A 61  ? N ILE F 57  O TYR A 264 ? O TYR F 299 
AA3 4 5 O GLN A 267 ? O GLN F 302 N TYR A 251 ? N TYR F 286 
AA3 5 6 O SER A 252 ? O SER F 287 N THR A 209 ? N THR F 244 
AA4 1 2 N LEU A 286 ? N LEU F 321 O LEU A 299 ? O LEU F 334 
AA4 2 3 N THR A 300 ? N THR F 335 O MET A 361 ? O MET F 396 
AA4 3 4 N ILE A 360 ? N ILE F 395 O ALA A 455 ? O ALA F 490 
AA5 1 2 N SER A 369 ? N SER F 404 O SER A 380 ? O SER F 415 
AA5 2 3 N VAL A 379 ? N VAL F 414 O ASP A 405 ? O ASP F 440 
AA6 1 2 O ILE A 397 ? O ILE F 432 N ALA A 389 ? N ALA F 424 
AA6 2 3 N THR A 388 ? N THR F 423 O SER A 416 ? O SER F 451 
AA6 3 4 N VAL A 415 ? N VAL F 450 O TYR A 422 ? O TYR F 457 
# 
_pdbx_entry_details.entry_id                   8W3G 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN F 70  ? ? -59.77  106.20  
2 1 THR F 72  ? ? -144.41 -19.36  
3 1 THR F 103 ? ? -118.99 60.63   
4 1 SER F 146 ? ? 69.83   -60.48  
5 1 LEU F 171 ? ? -93.13  33.65   
6 1 CYS F 290 ? ? -95.00  -100.08 
7 1 SER F 362 ? ? 71.26   -126.22 
8 1 ASN F 371 ? ? -104.88 50.45   
9 1 ASP F 489 ? ? -157.89 58.08   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  x+1/4,-z+1/4,y+3/4   
3  x+3/4,z+1/4,-y+1/4   
4  z+3/4,y+1/4,-x+1/4   
5  -z+1/4,y+3/4,x+1/4   
6  -y+1/4,x+3/4,z+1/4   
7  y+1/4,-x+1/4,z+3/4   
8  z,x,y                
9  y,z,x                
10 -y+1/2,-z,x+1/2      
11 z+1/2,-x+1/2,-y      
12 -y,z+1/2,-x+1/2      
13 -z+1/2,-x,y+1/2      
14 -z,x+1/2,-y+1/2      
15 y+1/2,-z+1/2,-x      
16 x+1/2,-y+1/2,-z      
17 -x,y+1/2,-z+1/2      
18 -x+1/2,-y,z+1/2      
19 y+3/4,x+1/4,-z+1/4   
20 -y+3/4,-x+3/4,-z+3/4 
21 z+1/4,-y+1/4,x+3/4   
22 -z+3/4,-y+3/4,-x+3/4 
23 -x+1/4,z+3/4,y+1/4   
24 -x+3/4,-z+3/4,-y+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 F MET -3  ? A MET 1   
2   1 Y 1 F GLY -2  ? A GLY 2   
3   1 Y 1 F ILE -1  ? A ILE 3   
4   1 Y 1 F LEU 0   ? A LEU 4   
5   1 Y 1 F PRO 1   ? A PRO 5   
6   1 Y 1 F SER 2   ? A SER 6   
7   1 Y 1 F PRO 3   ? A PRO 7   
8   1 Y 1 F GLY 4   ? A GLY 8   
9   1 Y 1 F MET 5   ? A MET 9   
10  1 Y 1 F PRO 6   ? A PRO 10  
11  1 Y 1 F ALA 7   ? A ALA 11  
12  1 Y 1 F LEU 8   ? A LEU 12  
13  1 Y 1 F LEU 9   ? A LEU 13  
14  1 Y 1 F SER 10  ? A SER 14  
15  1 Y 1 F LEU 11  ? A LEU 15  
16  1 Y 1 F VAL 12  ? A VAL 16  
17  1 Y 1 F SER 13  ? A SER 17  
18  1 Y 1 F LEU 14  ? A LEU 18  
19  1 Y 1 F LEU 15  ? A LEU 19  
20  1 Y 1 F SER 16  ? A SER 20  
21  1 Y 1 F VAL 17  ? A VAL 21  
22  1 Y 1 F LEU 18  ? A LEU 22  
23  1 Y 1 F LEU 19  ? A LEU 23  
24  1 Y 1 F MET 20  ? A MET 24  
25  1 Y 1 F GLY 21  ? A GLY 25  
26  1 Y 1 F CYS 22  ? A CYS 26  
27  1 Y 1 F VAL 23  ? A VAL 27  
28  1 Y 1 F ALA 24  ? A ALA 28  
29  1 Y 1 F GLU 25  ? A GLU 29  
30  1 Y 1 F ASP 510 ? A ASP 475 
31  1 Y 1 F GLU 511 ? A GLU 476 
32  1 Y 1 F LEU 512 ? A LEU 477 
33  1 Y 1 F LEU 513 ? A LEU 478 
34  1 Y 1 F ALA 514 ? A ALA 479 
35  1 Y 1 F SER 515 ? A SER 480 
36  1 Y 1 F GLY 516 ? A GLY 481 
37  1 Y 1 F GLY 517 ? A GLY 482 
38  1 Y 1 F GLY 518 ? A GLY 483 
39  1 Y 1 F GLY 519 ? A GLY 484 
40  1 Y 1 F SER 520 ? A SER 485 
41  1 Y 1 F ALA 521 ? A ALA 486 
42  1 Y 1 F SER 522 ? A SER 487 
43  1 Y 1 F GLY 523 ? A GLY 488 
44  1 Y 1 F ASP 524 ? A ASP 489 
45  1 Y 1 F ILE 525 ? A ILE 490 
46  1 Y 1 F ILE 526 ? A ILE 491 
47  1 Y 1 F LYS 527 ? A LYS 492 
48  1 Y 1 F LEU 528 ? A LEU 493 
49  1 Y 1 F LEU 529 ? A LEU 494 
50  1 Y 1 F ASN 530 ? A ASN 495 
51  1 Y 1 F GLU 531 ? A GLU 496 
52  1 Y 1 F GLN 532 ? A GLN 497 
53  1 Y 1 F VAL 533 ? A VAL 498 
54  1 Y 1 F ASN 534 ? A ASN 499 
55  1 Y 1 F LYS 535 ? A LYS 500 
56  1 Y 1 F GLU 536 ? A GLU 501 
57  1 Y 1 F MET 537 ? A MET 502 
58  1 Y 1 F GLN 538 ? A GLN 503 
59  1 Y 1 F SER 539 ? A SER 504 
60  1 Y 1 F SER 540 ? A SER 505 
61  1 Y 1 F ASN 541 ? A ASN 506 
62  1 Y 1 F LEU 542 ? A LEU 507 
63  1 Y 1 F TYR 543 ? A TYR 508 
64  1 Y 1 F MET 544 ? A MET 509 
65  1 Y 1 F SER 545 ? A SER 510 
66  1 Y 1 F MET 546 ? A MET 511 
67  1 Y 1 F SER 547 ? A SER 512 
68  1 Y 1 F SER 548 ? A SER 513 
69  1 Y 1 F TRP 549 ? A TRP 514 
70  1 Y 1 F CYS 550 ? A CYS 515 
71  1 Y 1 F TYR 551 ? A TYR 516 
72  1 Y 1 F THR 552 ? A THR 517 
73  1 Y 1 F HIS 553 ? A HIS 518 
74  1 Y 1 F SER 554 ? A SER 519 
75  1 Y 1 F LEU 555 ? A LEU 520 
76  1 Y 1 F ASP 556 ? A ASP 521 
77  1 Y 1 F GLY 557 ? A GLY 522 
78  1 Y 1 F ALA 558 ? A ALA 523 
79  1 Y 1 F GLY 559 ? A GLY 524 
80  1 Y 1 F LEU 560 ? A LEU 525 
81  1 Y 1 F PHE 561 ? A PHE 526 
82  1 Y 1 F LEU 562 ? A LEU 527 
83  1 Y 1 F PHE 563 ? A PHE 528 
84  1 Y 1 F ASP 564 ? A ASP 529 
85  1 Y 1 F HIS 565 ? A HIS 530 
86  1 Y 1 F ALA 566 ? A ALA 531 
87  1 Y 1 F ALA 567 ? A ALA 532 
88  1 Y 1 F GLU 568 ? A GLU 533 
89  1 Y 1 F GLU 569 ? A GLU 534 
90  1 Y 1 F TYR 570 ? A TYR 535 
91  1 Y 1 F GLU 571 ? A GLU 536 
92  1 Y 1 F HIS 572 ? A HIS 537 
93  1 Y 1 F ALA 573 ? A ALA 538 
94  1 Y 1 F LYS 574 ? A LYS 539 
95  1 Y 1 F LYS 575 ? A LYS 540 
96  1 Y 1 F LEU 576 ? A LEU 541 
97  1 Y 1 F ILE 577 ? A ILE 542 
98  1 Y 1 F ILE 578 ? A ILE 543 
99  1 Y 1 F PHE 579 ? A PHE 544 
100 1 Y 1 F LEU 580 ? A LEU 545 
101 1 Y 1 F ASN 581 ? A ASN 546 
102 1 Y 1 F GLU 582 ? A GLU 547 
103 1 Y 1 F ASN 583 ? A ASN 548 
104 1 Y 1 F ASN 584 ? A ASN 549 
105 1 Y 1 F VAL 585 ? A VAL 550 
106 1 Y 1 F PRO 586 ? A PRO 551 
107 1 Y 1 F VAL 587 ? A VAL 552 
108 1 Y 1 F GLN 588 ? A GLN 553 
109 1 Y 1 F LEU 589 ? A LEU 554 
110 1 Y 1 F THR 590 ? A THR 555 
111 1 Y 1 F SER 591 ? A SER 556 
112 1 Y 1 F ILE 592 ? A ILE 557 
113 1 Y 1 F SER 593 ? A SER 558 
114 1 Y 1 F ALA 594 ? A ALA 559 
115 1 Y 1 F PRO 595 ? A PRO 560 
116 1 Y 1 F GLU 596 ? A GLU 561 
117 1 Y 1 F HIS 597 ? A HIS 562 
118 1 Y 1 F LYS 598 ? A LYS 563 
119 1 Y 1 F PHE 599 ? A PHE 564 
120 1 Y 1 F GLU 600 ? A GLU 565 
121 1 Y 1 F GLY 601 ? A GLY 566 
122 1 Y 1 F LEU 602 ? A LEU 567 
123 1 Y 1 F THR 603 ? A THR 568 
124 1 Y 1 F GLN 604 ? A GLN 569 
125 1 Y 1 F ILE 605 ? A ILE 570 
126 1 Y 1 F PHE 606 ? A PHE 571 
127 1 Y 1 F GLN 607 ? A GLN 572 
128 1 Y 1 F LYS 608 ? A LYS 573 
129 1 Y 1 F ALA 609 ? A ALA 574 
130 1 Y 1 F TYR 610 ? A TYR 575 
131 1 Y 1 F GLU 611 ? A GLU 576 
132 1 Y 1 F HIS 612 ? A HIS 577 
133 1 Y 1 F GLU 613 ? A GLU 578 
134 1 Y 1 F GLN 614 ? A GLN 579 
135 1 Y 1 F HIS 615 ? A HIS 580 
136 1 Y 1 F ILE 616 ? A ILE 581 
137 1 Y 1 F SER 617 ? A SER 582 
138 1 Y 1 F GLU 618 ? A GLU 583 
139 1 Y 1 F SER 619 ? A SER 584 
140 1 Y 1 F ILE 620 ? A ILE 585 
141 1 Y 1 F ASN 621 ? A ASN 586 
142 1 Y 1 F ASN 622 ? A ASN 587 
143 1 Y 1 F ILE 623 ? A ILE 588 
144 1 Y 1 F VAL 624 ? A VAL 589 
145 1 Y 1 F ASP 625 ? A ASP 590 
146 1 Y 1 F HIS 626 ? A HIS 591 
147 1 Y 1 F ALA 627 ? A ALA 592 
148 1 Y 1 F ILE 628 ? A ILE 593 
149 1 Y 1 F LYS 629 ? A LYS 594 
150 1 Y 1 F SER 630 ? A SER 595 
151 1 Y 1 F LYS 631 ? A LYS 596 
152 1 Y 1 F ASP 632 ? A ASP 597 
153 1 Y 1 F HIS 633 ? A HIS 598 
154 1 Y 1 F ALA 634 ? A ALA 599 
155 1 Y 1 F THR 635 ? A THR 600 
156 1 Y 1 F PHE 636 ? A PHE 601 
157 1 Y 1 F ASN 637 ? A ASN 602 
158 1 Y 1 F PHE 638 ? A PHE 603 
159 1 Y 1 F LEU 639 ? A LEU 604 
160 1 Y 1 F GLN 640 ? A GLN 605 
161 1 Y 1 F TRP 641 ? A TRP 606 
162 1 Y 1 F TYR 642 ? A TYR 607 
163 1 Y 1 F VAL 643 ? A VAL 608 
164 1 Y 1 F ALA 644 ? A ALA 609 
165 1 Y 1 F GLU 645 ? A GLU 610 
166 1 Y 1 F GLN 646 ? A GLN 611 
167 1 Y 1 F HIS 647 ? A HIS 612 
168 1 Y 1 F GLU 648 ? A GLU 613 
169 1 Y 1 F GLU 649 ? A GLU 614 
170 1 Y 1 F GLU 650 ? A GLU 615 
171 1 Y 1 F VAL 651 ? A VAL 616 
172 1 Y 1 F LEU 652 ? A LEU 617 
173 1 Y 1 F PHE 653 ? A PHE 618 
174 1 Y 1 F LYS 654 ? A LYS 619 
175 1 Y 1 F ASP 655 ? A ASP 620 
176 1 Y 1 F ILE 656 ? A ILE 621 
177 1 Y 1 F LEU 657 ? A LEU 622 
178 1 Y 1 F ASP 658 ? A ASP 623 
179 1 Y 1 F LYS 659 ? A LYS 624 
180 1 Y 1 F ILE 660 ? A ILE 625 
181 1 Y 1 F GLU 661 ? A GLU 626 
182 1 Y 1 F LEU 662 ? A LEU 627 
183 1 Y 1 F ILE 663 ? A ILE 628 
184 1 Y 1 F GLY 664 ? A GLY 629 
185 1 Y 1 F ASN 665 ? A ASN 630 
186 1 Y 1 F GLU 666 ? A GLU 631 
187 1 Y 1 F ASN 667 ? A ASN 632 
188 1 Y 1 F HIS 668 ? A HIS 633 
189 1 Y 1 F GLY 669 ? A GLY 634 
190 1 Y 1 F LEU 670 ? A LEU 635 
191 1 Y 1 F TYR 671 ? A TYR 636 
192 1 Y 1 F LEU 672 ? A LEU 637 
193 1 Y 1 F ALA 673 ? A ALA 638 
194 1 Y 1 F ASP 674 ? A ASP 639 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EDO C1   C N N 88  
EDO O1   O N N 89  
EDO C2   C N N 90  
EDO O2   O N N 91  
EDO H11  H N N 92  
EDO H12  H N N 93  
EDO HO1  H N N 94  
EDO H21  H N N 95  
EDO H22  H N N 96  
EDO HO2  H N N 97  
GLN N    N N N 98  
GLN CA   C N S 99  
GLN C    C N N 100 
GLN O    O N N 101 
GLN CB   C N N 102 
GLN CG   C N N 103 
GLN CD   C N N 104 
GLN OE1  O N N 105 
GLN NE2  N N N 106 
GLN OXT  O N N 107 
GLN H    H N N 108 
GLN H2   H N N 109 
GLN HA   H N N 110 
GLN HB2  H N N 111 
GLN HB3  H N N 112 
GLN HG2  H N N 113 
GLN HG3  H N N 114 
GLN HE21 H N N 115 
GLN HE22 H N N 116 
GLN HXT  H N N 117 
GLU N    N N N 118 
GLU CA   C N S 119 
GLU C    C N N 120 
GLU O    O N N 121 
GLU CB   C N N 122 
GLU CG   C N N 123 
GLU CD   C N N 124 
GLU OE1  O N N 125 
GLU OE2  O N N 126 
GLU OXT  O N N 127 
GLU H    H N N 128 
GLU H2   H N N 129 
GLU HA   H N N 130 
GLU HB2  H N N 131 
GLU HB3  H N N 132 
GLU HG2  H N N 133 
GLU HG3  H N N 134 
GLU HE2  H N N 135 
GLU HXT  H N N 136 
GLY N    N N N 137 
GLY CA   C N N 138 
GLY C    C N N 139 
GLY O    O N N 140 
GLY OXT  O N N 141 
GLY H    H N N 142 
GLY H2   H N N 143 
GLY HA2  H N N 144 
GLY HA3  H N N 145 
GLY HXT  H N N 146 
HIS N    N N N 147 
HIS CA   C N S 148 
HIS C    C N N 149 
HIS O    O N N 150 
HIS CB   C N N 151 
HIS CG   C Y N 152 
HIS ND1  N Y N 153 
HIS CD2  C Y N 154 
HIS CE1  C Y N 155 
HIS NE2  N Y N 156 
HIS OXT  O N N 157 
HIS H    H N N 158 
HIS H2   H N N 159 
HIS HA   H N N 160 
HIS HB2  H N N 161 
HIS HB3  H N N 162 
HIS HD1  H N N 163 
HIS HD2  H N N 164 
HIS HE1  H N N 165 
HIS HE2  H N N 166 
HIS HXT  H N N 167 
HOH O    O N N 168 
HOH H1   H N N 169 
HOH H2   H N N 170 
ILE N    N N N 171 
ILE CA   C N S 172 
ILE C    C N N 173 
ILE O    O N N 174 
ILE CB   C N S 175 
ILE CG1  C N N 176 
ILE CG2  C N N 177 
ILE CD1  C N N 178 
ILE OXT  O N N 179 
ILE H    H N N 180 
ILE H2   H N N 181 
ILE HA   H N N 182 
ILE HB   H N N 183 
ILE HG12 H N N 184 
ILE HG13 H N N 185 
ILE HG21 H N N 186 
ILE HG22 H N N 187 
ILE HG23 H N N 188 
ILE HD11 H N N 189 
ILE HD12 H N N 190 
ILE HD13 H N N 191 
ILE HXT  H N N 192 
LEU N    N N N 193 
LEU CA   C N S 194 
LEU C    C N N 195 
LEU O    O N N 196 
LEU CB   C N N 197 
LEU CG   C N N 198 
LEU CD1  C N N 199 
LEU CD2  C N N 200 
LEU OXT  O N N 201 
LEU H    H N N 202 
LEU H2   H N N 203 
LEU HA   H N N 204 
LEU HB2  H N N 205 
LEU HB3  H N N 206 
LEU HG   H N N 207 
LEU HD11 H N N 208 
LEU HD12 H N N 209 
LEU HD13 H N N 210 
LEU HD21 H N N 211 
LEU HD22 H N N 212 
LEU HD23 H N N 213 
LEU HXT  H N N 214 
LYS N    N N N 215 
LYS CA   C N S 216 
LYS C    C N N 217 
LYS O    O N N 218 
LYS CB   C N N 219 
LYS CG   C N N 220 
LYS CD   C N N 221 
LYS CE   C N N 222 
LYS NZ   N N N 223 
LYS OXT  O N N 224 
LYS H    H N N 225 
LYS H2   H N N 226 
LYS HA   H N N 227 
LYS HB2  H N N 228 
LYS HB3  H N N 229 
LYS HG2  H N N 230 
LYS HG3  H N N 231 
LYS HD2  H N N 232 
LYS HD3  H N N 233 
LYS HE2  H N N 234 
LYS HE3  H N N 235 
LYS HZ1  H N N 236 
LYS HZ2  H N N 237 
LYS HZ3  H N N 238 
LYS HXT  H N N 239 
MET N    N N N 240 
MET CA   C N S 241 
MET C    C N N 242 
MET O    O N N 243 
MET CB   C N N 244 
MET CG   C N N 245 
MET SD   S N N 246 
MET CE   C N N 247 
MET OXT  O N N 248 
MET H    H N N 249 
MET H2   H N N 250 
MET HA   H N N 251 
MET HB2  H N N 252 
MET HB3  H N N 253 
MET HG2  H N N 254 
MET HG3  H N N 255 
MET HE1  H N N 256 
MET HE2  H N N 257 
MET HE3  H N N 258 
MET HXT  H N N 259 
NAG C1   C N R 260 
NAG C2   C N R 261 
NAG C3   C N R 262 
NAG C4   C N S 263 
NAG C5   C N R 264 
NAG C6   C N N 265 
NAG C7   C N N 266 
NAG C8   C N N 267 
NAG N2   N N N 268 
NAG O1   O N N 269 
NAG O3   O N N 270 
NAG O4   O N N 271 
NAG O5   O N N 272 
NAG O6   O N N 273 
NAG O7   O N N 274 
NAG H1   H N N 275 
NAG H2   H N N 276 
NAG H3   H N N 277 
NAG H4   H N N 278 
NAG H5   H N N 279 
NAG H61  H N N 280 
NAG H62  H N N 281 
NAG H81  H N N 282 
NAG H82  H N N 283 
NAG H83  H N N 284 
NAG HN2  H N N 285 
NAG HO1  H N N 286 
NAG HO3  H N N 287 
NAG HO4  H N N 288 
NAG HO6  H N N 289 
PHE N    N N N 290 
PHE CA   C N S 291 
PHE C    C N N 292 
PHE O    O N N 293 
PHE CB   C N N 294 
PHE CG   C Y N 295 
PHE CD1  C Y N 296 
PHE CD2  C Y N 297 
PHE CE1  C Y N 298 
PHE CE2  C Y N 299 
PHE CZ   C Y N 300 
PHE OXT  O N N 301 
PHE H    H N N 302 
PHE H2   H N N 303 
PHE HA   H N N 304 
PHE HB2  H N N 305 
PHE HB3  H N N 306 
PHE HD1  H N N 307 
PHE HD2  H N N 308 
PHE HE1  H N N 309 
PHE HE2  H N N 310 
PHE HZ   H N N 311 
PHE HXT  H N N 312 
PRO N    N N N 313 
PRO CA   C N S 314 
PRO C    C N N 315 
PRO O    O N N 316 
PRO CB   C N N 317 
PRO CG   C N N 318 
PRO CD   C N N 319 
PRO OXT  O N N 320 
PRO H    H N N 321 
PRO HA   H N N 322 
PRO HB2  H N N 323 
PRO HB3  H N N 324 
PRO HG2  H N N 325 
PRO HG3  H N N 326 
PRO HD2  H N N 327 
PRO HD3  H N N 328 
PRO HXT  H N N 329 
SER N    N N N 330 
SER CA   C N S 331 
SER C    C N N 332 
SER O    O N N 333 
SER CB   C N N 334 
SER OG   O N N 335 
SER OXT  O N N 336 
SER H    H N N 337 
SER H2   H N N 338 
SER HA   H N N 339 
SER HB2  H N N 340 
SER HB3  H N N 341 
SER HG   H N N 342 
SER HXT  H N N 343 
THR N    N N N 344 
THR CA   C N S 345 
THR C    C N N 346 
THR O    O N N 347 
THR CB   C N R 348 
THR OG1  O N N 349 
THR CG2  C N N 350 
THR OXT  O N N 351 
THR H    H N N 352 
THR H2   H N N 353 
THR HA   H N N 354 
THR HB   H N N 355 
THR HG1  H N N 356 
THR HG21 H N N 357 
THR HG22 H N N 358 
THR HG23 H N N 359 
THR HXT  H N N 360 
TRP N    N N N 361 
TRP CA   C N S 362 
TRP C    C N N 363 
TRP O    O N N 364 
TRP CB   C N N 365 
TRP CG   C Y N 366 
TRP CD1  C Y N 367 
TRP CD2  C Y N 368 
TRP NE1  N Y N 369 
TRP CE2  C Y N 370 
TRP CE3  C Y N 371 
TRP CZ2  C Y N 372 
TRP CZ3  C Y N 373 
TRP CH2  C Y N 374 
TRP OXT  O N N 375 
TRP H    H N N 376 
TRP H2   H N N 377 
TRP HA   H N N 378 
TRP HB2  H N N 379 
TRP HB3  H N N 380 
TRP HD1  H N N 381 
TRP HE1  H N N 382 
TRP HE3  H N N 383 
TRP HZ2  H N N 384 
TRP HZ3  H N N 385 
TRP HH2  H N N 386 
TRP HXT  H N N 387 
TYR N    N N N 388 
TYR CA   C N S 389 
TYR C    C N N 390 
TYR O    O N N 391 
TYR CB   C N N 392 
TYR CG   C Y N 393 
TYR CD1  C Y N 394 
TYR CD2  C Y N 395 
TYR CE1  C Y N 396 
TYR CE2  C Y N 397 
TYR CZ   C Y N 398 
TYR OH   O N N 399 
TYR OXT  O N N 400 
TYR H    H N N 401 
TYR H2   H N N 402 
TYR HA   H N N 403 
TYR HB2  H N N 404 
TYR HB3  H N N 405 
TYR HD1  H N N 406 
TYR HD2  H N N 407 
TYR HE1  H N N 408 
TYR HE2  H N N 409 
TYR HH   H N N 410 
TYR HXT  H N N 411 
VAL N    N N N 412 
VAL CA   C N S 413 
VAL C    C N N 414 
VAL O    O N N 415 
VAL CB   C N N 416 
VAL CG1  C N N 417 
VAL CG2  C N N 418 
VAL OXT  O N N 419 
VAL H    H N N 420 
VAL H2   H N N 421 
VAL HA   H N N 422 
VAL HB   H N N 423 
VAL HG11 H N N 424 
VAL HG12 H N N 425 
VAL HG13 H N N 426 
VAL HG21 H N N 427 
VAL HG22 H N N 428 
VAL HG23 H N N 429 
VAL HXT  H N N 430 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
NAG C1  C2   sing N N 246 
NAG C1  O1   sing N N 247 
NAG C1  O5   sing N N 248 
NAG C1  H1   sing N N 249 
NAG C2  C3   sing N N 250 
NAG C2  N2   sing N N 251 
NAG C2  H2   sing N N 252 
NAG C3  C4   sing N N 253 
NAG C3  O3   sing N N 254 
NAG C3  H3   sing N N 255 
NAG C4  C5   sing N N 256 
NAG C4  O4   sing N N 257 
NAG C4  H4   sing N N 258 
NAG C5  C6   sing N N 259 
NAG C5  O5   sing N N 260 
NAG C5  H5   sing N N 261 
NAG C6  O6   sing N N 262 
NAG C6  H61  sing N N 263 
NAG C6  H62  sing N N 264 
NAG C7  C8   sing N N 265 
NAG C7  N2   sing N N 266 
NAG C7  O7   doub N N 267 
NAG C8  H81  sing N N 268 
NAG C8  H82  sing N N 269 
NAG C8  H83  sing N N 270 
NAG N2  HN2  sing N N 271 
NAG O1  HO1  sing N N 272 
NAG O3  HO3  sing N N 273 
NAG O4  HO4  sing N N 274 
NAG O6  HO6  sing N N 275 
PHE N   CA   sing N N 276 
PHE N   H    sing N N 277 
PHE N   H2   sing N N 278 
PHE CA  C    sing N N 279 
PHE CA  CB   sing N N 280 
PHE CA  HA   sing N N 281 
PHE C   O    doub N N 282 
PHE C   OXT  sing N N 283 
PHE CB  CG   sing N N 284 
PHE CB  HB2  sing N N 285 
PHE CB  HB3  sing N N 286 
PHE CG  CD1  doub Y N 287 
PHE CG  CD2  sing Y N 288 
PHE CD1 CE1  sing Y N 289 
PHE CD1 HD1  sing N N 290 
PHE CD2 CE2  doub Y N 291 
PHE CD2 HD2  sing N N 292 
PHE CE1 CZ   doub Y N 293 
PHE CE1 HE1  sing N N 294 
PHE CE2 CZ   sing Y N 295 
PHE CE2 HE2  sing N N 296 
PHE CZ  HZ   sing N N 297 
PHE OXT HXT  sing N N 298 
PRO N   CA   sing N N 299 
PRO N   CD   sing N N 300 
PRO N   H    sing N N 301 
PRO CA  C    sing N N 302 
PRO CA  CB   sing N N 303 
PRO CA  HA   sing N N 304 
PRO C   O    doub N N 305 
PRO C   OXT  sing N N 306 
PRO CB  CG   sing N N 307 
PRO CB  HB2  sing N N 308 
PRO CB  HB3  sing N N 309 
PRO CG  CD   sing N N 310 
PRO CG  HG2  sing N N 311 
PRO CG  HG3  sing N N 312 
PRO CD  HD2  sing N N 313 
PRO CD  HD3  sing N N 314 
PRO OXT HXT  sing N N 315 
SER N   CA   sing N N 316 
SER N   H    sing N N 317 
SER N   H2   sing N N 318 
SER CA  C    sing N N 319 
SER CA  CB   sing N N 320 
SER CA  HA   sing N N 321 
SER C   O    doub N N 322 
SER C   OXT  sing N N 323 
SER CB  OG   sing N N 324 
SER CB  HB2  sing N N 325 
SER CB  HB3  sing N N 326 
SER OG  HG   sing N N 327 
SER OXT HXT  sing N N 328 
THR N   CA   sing N N 329 
THR N   H    sing N N 330 
THR N   H2   sing N N 331 
THR CA  C    sing N N 332 
THR CA  CB   sing N N 333 
THR CA  HA   sing N N 334 
THR C   O    doub N N 335 
THR C   OXT  sing N N 336 
THR CB  OG1  sing N N 337 
THR CB  CG2  sing N N 338 
THR CB  HB   sing N N 339 
THR OG1 HG1  sing N N 340 
THR CG2 HG21 sing N N 341 
THR CG2 HG22 sing N N 342 
THR CG2 HG23 sing N N 343 
THR OXT HXT  sing N N 344 
TRP N   CA   sing N N 345 
TRP N   H    sing N N 346 
TRP N   H2   sing N N 347 
TRP CA  C    sing N N 348 
TRP CA  CB   sing N N 349 
TRP CA  HA   sing N N 350 
TRP C   O    doub N N 351 
TRP C   OXT  sing N N 352 
TRP CB  CG   sing N N 353 
TRP CB  HB2  sing N N 354 
TRP CB  HB3  sing N N 355 
TRP CG  CD1  doub Y N 356 
TRP CG  CD2  sing Y N 357 
TRP CD1 NE1  sing Y N 358 
TRP CD1 HD1  sing N N 359 
TRP CD2 CE2  doub Y N 360 
TRP CD2 CE3  sing Y N 361 
TRP NE1 CE2  sing Y N 362 
TRP NE1 HE1  sing N N 363 
TRP CE2 CZ2  sing Y N 364 
TRP CE3 CZ3  doub Y N 365 
TRP CE3 HE3  sing N N 366 
TRP CZ2 CH2  doub Y N 367 
TRP CZ2 HZ2  sing N N 368 
TRP CZ3 CH2  sing Y N 369 
TRP CZ3 HZ3  sing N N 370 
TRP CH2 HH2  sing N N 371 
TRP OXT HXT  sing N N 372 
TYR N   CA   sing N N 373 
TYR N   H    sing N N 374 
TYR N   H2   sing N N 375 
TYR CA  C    sing N N 376 
TYR CA  CB   sing N N 377 
TYR CA  HA   sing N N 378 
TYR C   O    doub N N 379 
TYR C   OXT  sing N N 380 
TYR CB  CG   sing N N 381 
TYR CB  HB2  sing N N 382 
TYR CB  HB3  sing N N 383 
TYR CG  CD1  doub Y N 384 
TYR CG  CD2  sing Y N 385 
TYR CD1 CE1  sing Y N 386 
TYR CD1 HD1  sing N N 387 
TYR CD2 CE2  doub Y N 388 
TYR CD2 HD2  sing N N 389 
TYR CE1 CZ   doub Y N 390 
TYR CE1 HE1  sing N N 391 
TYR CE2 CZ   sing Y N 392 
TYR CE2 HE2  sing N N 393 
TYR CZ  OH   sing N N 394 
TYR OH  HH   sing N N 395 
TYR OXT HXT  sing N N 396 
VAL N   CA   sing N N 397 
VAL N   H    sing N N 398 
VAL N   H2   sing N N 399 
VAL CA  C    sing N N 400 
VAL CA  CB   sing N N 401 
VAL CA  HA   sing N N 402 
VAL C   O    doub N N 403 
VAL C   OXT  sing N N 404 
VAL CB  CG1  sing N N 405 
VAL CB  CG2  sing N N 406 
VAL CB  HB   sing N N 407 
VAL CG1 HG11 sing N N 408 
VAL CG1 HG12 sing N N 409 
VAL CG1 HG13 sing N N 410 
VAL CG2 HG21 sing N N 411 
VAL CG2 HG22 sing N N 412 
VAL CG2 HG23 sing N N 413 
VAL OXT HXT  sing N N 414 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5K6I 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 41 3 2' 
_space_group.name_Hall        'P 4bd 2ab 3' 
_space_group.IT_number        213 
_space_group.crystal_system   cubic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W3G 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005923 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005923 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005923 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 30  ? 160.33700 333.58000 34.10700  1.000 73.90880  ? 26  GLN F N   1 
ATOM   2    C CA  . GLN A 1 30  ? 161.44100 334.47600 34.47100  1.000 75.55536  ? 26  GLN F CA  1 
ATOM   3    C C   . GLN A 1 30  ? 160.96700 335.90600 34.74300  1.000 74.52613  ? 26  GLN F C   1 
ATOM   4    O O   . GLN A 1 30  ? 160.19200 336.46400 33.96600  1.000 70.03835  ? 26  GLN F O   1 
ATOM   5    C CB  . GLN A 1 30  ? 162.51000 334.49200 33.37600  1.000 77.11280  ? 26  GLN F CB  1 
ATOM   6    C CG  . GLN A 1 30  ? 163.16900 333.13900 33.16000  1.000 77.83144  ? 26  GLN F CG  1 
ATOM   7    C CD  . GLN A 1 30  ? 163.71300 332.56700 34.45900  1.000 76.52592  ? 26  GLN F CD  1 
ATOM   8    O OE1 . GLN A 1 30  ? 164.58500 333.16800 35.10200  1.000 73.23086  ? 26  GLN F OE1 1 
ATOM   9    N NE2 . GLN A 1 30  ? 163.19000 331.40200 34.86000  1.000 74.58733  ? 26  GLN F NE2 1 
ATOM   10   N N   . ASN A 1 31  ? 161.36200 336.47200 35.88500  1.000 73.05487  ? 27  ASN F N   1 
ATOM   11   C CA  . ASN A 1 31  ? 160.94400 337.82200 36.22200  1.000 66.98183  ? 27  ASN F CA  1 
ATOM   12   C C   . ASN A 1 31  ? 162.00600 338.82100 35.74500  1.000 64.70110  ? 27  ASN F C   1 
ATOM   13   O O   . ASN A 1 31  ? 163.10400 338.88000 36.30800  1.000 58.00812  ? 27  ASN F O   1 
ATOM   14   C CB  . ASN A 1 31  ? 160.79600 337.85700 37.74000  1.000 72.12739  ? 27  ASN F CB  1 
ATOM   15   C CG  . ASN A 1 31  ? 159.59000 337.03200 38.22800  1.000 86.52252  ? 27  ASN F CG  1 
ATOM   16   O OD1 . ASN A 1 31  ? 158.70700 336.67000 37.44200  1.000 82.75303  ? 27  ASN F OD1 1 
ATOM   17   N ND2 . ASN A 1 31  ? 159.61700 336.64100 39.50600  1.000 88.40336  ? 27  ASN F ND2 1 
ATOM   18   N N   . ILE A 1 32  ? 161.63600 339.70300 34.82300  1.000 61.51147  ? 28  ILE F N   1 
ATOM   19   C CA  . ILE A 1 32  ? 162.54100 340.74600 34.33600  1.000 49.87315  ? 28  ILE F CA  1 
ATOM   20   C C   . ILE A 1 32  ? 162.53300 341.93900 35.27000  1.000 50.42419  ? 28  ILE F C   1 
ATOM   21   O O   . ILE A 1 32  ? 161.46100 342.41400 35.65300  1.000 56.52122  ? 28  ILE F O   1 
ATOM   22   C CB  . ILE A 1 32  ? 162.21100 341.17500 32.90600  1.000 55.09124  ? 28  ILE F CB  1 
ATOM   23   C CG1 . ILE A 1 32  ? 162.34600 339.98500 31.98400  1.000 50.84677  ? 28  ILE F CG1 1 
ATOM   24   C CG2 . ILE A 1 32  ? 163.21800 342.25300 32.47000  1.000 48.28928  ? 28  ILE F CG2 1 
ATOM   25   C CD1 . ILE A 1 32  ? 163.67100 339.27400 32.19700  1.000 48.82655  ? 28  ILE F CD1 1 
ATOM   26   N N   . THR A 1 33  ? 163.70600 342.37700 35.71800  1.000 49.97760  ? 29  THR F N   1 
ATOM   27   C CA  . THR A 1 33  ? 163.73600 343.55200 36.57400  1.000 45.35260  ? 29  THR F CA  1 
ATOM   28   C C   . THR A 1 33  ? 164.73900 344.52300 35.97100  1.000 51.19059  ? 29  THR F C   1 
ATOM   29   O O   . THR A 1 33  ? 165.49300 344.16800 35.06700  1.000 49.06787  ? 29  THR F O   1 
ATOM   30   C CB  . THR A 1 33  ? 164.15600 343.23000 38.00900  1.000 45.26341  ? 29  THR F CB  1 
ATOM   31   O OG1 . THR A 1 33  ? 165.43000 342.59200 37.99100  1.000 52.73100  ? 29  THR F OG1 1 
ATOM   32   C CG2 . THR A 1 33  ? 163.14500 342.30300 38.70600  1.000 44.67670  ? 29  THR F CG2 1 
ATOM   33   N N   . GLU A 1 34  ? 164.67100 345.78100 36.39200  1.000 48.13719  ? 30  GLU F N   1 
ATOM   34   C CA  . GLU A 1 34  ? 165.58300 346.80500 35.89400  1.000 47.59256  ? 30  GLU F CA  1 
ATOM   35   C C   . GLU A 1 34  ? 165.98800 347.71400 37.04300  1.000 44.43264  ? 30  GLU F C   1 
ATOM   36   O O   . GLU A 1 34  ? 165.16200 348.03200 37.90000  1.000 51.32841  ? 30  GLU F O   1 
ATOM   37   C CB  . GLU A 1 34  ? 164.95800 347.61200 34.74300  1.000 49.68925  ? 30  GLU F CB  1 
ATOM   38   C CG  . GLU A 1 34  ? 165.92800 348.43700 33.90700  1.000 40.10843  ? 30  GLU F CG  1 
ATOM   39   C CD  . GLU A 1 34  ? 165.38000 348.71800 32.51600  1.000 45.51479  ? 30  GLU F CD  1 
ATOM   40   O OE1 . GLU A 1 34  ? 165.59000 347.88800 31.60900  1.000 45.35312  ? 30  GLU F OE1 1 
ATOM   41   O OE2 . GLU A 1 34  ? 164.73400 349.77300 32.31300  1.000 46.50939  ? 30  GLU F OE2 1 
ATOM   42   N N   . GLU A 1 35  ? 167.16800 348.31100 36.92200  1.000 43.59293  ? 31  GLU F N   1 
ATOM   43   C CA  . GLU A 1 35  ? 167.69900 349.25000 37.91600  1.000 46.54548  ? 31  GLU F CA  1 
ATOM   44   C C   . GLU A 1 35  ? 168.37700 350.41100 37.22200  1.000 46.05582  ? 31  GLU F C   1 
ATOM   45   O O   . GLU A 1 35  ? 169.24700 350.18400 36.36900  1.000 45.58639  ? 31  GLU F O   1 
ATOM   46   C CB  . GLU A 1 35  ? 168.72800 348.64400 38.87600  1.000 46.01010  ? 31  GLU F CB  1 
ATOM   47   C CG  . GLU A 1 35  ? 168.21900 347.70200 39.94900  1.000 56.79643  ? 31  GLU F CG  1 
ATOM   48   C CD  . GLU A 1 35  ? 169.37000 347.10700 40.75600  1.000 63.37396  ? 31  GLU F CD  1 
ATOM   49   O OE1 . GLU A 1 35  ? 170.35300 346.62500 40.15700  1.000 64.39371  ? 31  GLU F OE1 1 
ATOM   50   O OE2 . GLU A 1 35  ? 169.28700 347.10600 41.99500  1.000 69.57714  ? 31  GLU F OE2 1 
ATOM   51   N N   . PHE A 1 36  ? 167.85300 351.61500 37.42500  1.000 43.34655  ? 32  PHE F N   1 
ATOM   52   C CA  . PHE A 1 36  ? 168.48300 352.82600 36.90800  1.000 37.30477  ? 32  PHE F CA  1 
ATOM   53   C C   . PHE A 1 36  ? 169.35600 353.48600 37.96600  1.000 45.02865  ? 32  PHE F C   1 
ATOM   54   O O   . PHE A 1 36  ? 168.90800 353.70000 39.09100  1.000 48.48977  ? 32  PHE F O   1 
ATOM   55   C CB  . PHE A 1 36  ? 167.44300 353.82400 36.42200  1.000 38.33704  ? 32  PHE F CB  1 
ATOM   56   C CG  . PHE A 1 36  ? 168.01900 355.18200 36.09300  1.000 43.04959  ? 32  PHE F CG  1 
ATOM   57   C CD1 . PHE A 1 36  ? 168.73400 355.40200 34.91400  1.000 40.54928  ? 32  PHE F CD1 1 
ATOM   58   C CD2 . PHE A 1 36  ? 167.76900 356.26500 36.93500  1.000 42.49173  ? 32  PHE F CD2 1 
ATOM   59   C CE1 . PHE A 1 36  ? 169.23600 356.66900 34.59200  1.000 42.02096  ? 32  PHE F CE1 1 
ATOM   60   C CE2 . PHE A 1 36  ? 168.27300 357.54000 36.62100  1.000 45.28929  ? 32  PHE F CE2 1 
ATOM   61   C CZ  . PHE A 1 36  ? 169.00900 357.74000 35.42900  1.000 38.73533  ? 32  PHE F CZ  1 
ATOM   62   N N   . TYR A 1 37  ? 170.60800 353.81600 37.60700  1.000 41.38016  ? 33  TYR F N   1 
ATOM   63   C CA  . TYR A 1 37  ? 171.53100 354.43400 38.54700  1.000 43.95484  ? 33  TYR F CA  1 
ATOM   64   C C   . TYR A 1 37  ? 171.63300 355.89000 38.10100  1.000 43.63546  ? 33  TYR F C   1 
ATOM   65   O O   . TYR A 1 37  ? 172.28900 356.20700 37.08200  1.000 41.15475  ? 33  TYR F O   1 
ATOM   66   C CB  . TYR A 1 37  ? 172.90200 353.76100 38.56100  1.000 42.62315  ? 33  TYR F CB  1 
ATOM   67   C CG  . TYR A 1 37  ? 172.69900 352.28100 38.73900  1.000 49.39698  ? 33  TYR F CG  1 
ATOM   68   C CD1 . TYR A 1 37  ? 172.40400 351.71900 39.96300  1.000 47.07040  ? 33  TYR F CD1 1 
ATOM   69   C CD2 . TYR A 1 37  ? 172.97300 351.42400 37.67100  1.000 45.62272  ? 33  TYR F CD2 1 
ATOM   70   C CE1 . TYR A 1 37  ? 172.21700 350.33900 40.07900  1.000 47.79926  ? 33  TYR F CE1 1 
ATOM   71   C CE2 . TYR A 1 37  ? 172.83000 350.06200 37.78400  1.000 51.24018  ? 33  TYR F CE2 1 
ATOM   72   C CZ  . TYR A 1 37  ? 172.45800 349.52000 38.99100  1.000 51.22111  ? 33  TYR F CZ  1 
ATOM   73   O OH  . TYR A 1 37  ? 172.29700 348.15900 39.06000  1.000 54.29411  ? 33  TYR F OH  1 
ATOM   74   N N   . GLN A 1 38  ? 170.95500 356.75000 38.86400  1.000 40.48254  ? 34  GLN F N   1 
ATOM   75   C CA  . GLN A 1 38  ? 170.95600 358.17900 38.60500  1.000 41.79717  ? 34  GLN F CA  1 
ATOM   76   C C   . GLN A 1 38  ? 172.34800 358.76300 38.72100  1.000 41.87733  ? 34  GLN F C   1 
ATOM   77   O O   . GLN A 1 38  ? 172.71600 359.65600 37.95500  1.000 41.60532  ? 34  GLN F O   1 
ATOM   78   C CB  . GLN A 1 38  ? 170.02800 358.87500 39.60800  1.000 42.89413  ? 34  GLN F CB  1 
ATOM   79   C CG  . GLN A 1 38  ? 170.01400 360.38500 39.47300  1.000 43.32584  ? 34  GLN F CG  1 
ATOM   80   C CD  . GLN A 1 38  ? 169.18000 361.09200 40.54000  1.000 47.93882  ? 34  GLN F CD  1 
ATOM   81   O OE1 . GLN A 1 38  ? 168.86000 360.52300 41.57000  1.000 47.29889  ? 34  GLN F OE1 1 
ATOM   82   N NE2 . GLN A 1 38  ? 168.82300 362.34700 40.27300  1.000 49.63979  ? 34  GLN F NE2 1 
ATOM   83   N N   . SER A 1 39  ? 173.18100 358.16400 39.54700  1.000 42.76172  ? 35  SER F N   1 
ATOM   84   C CA  . SER A 1 39  ? 174.51500 358.70800 39.76900  1.000 46.76558  ? 35  SER F CA  1 
ATOM   85   C C   . SER A 1 39  ? 175.40900 358.53400 38.55600  1.000 38.47777  ? 35  SER F C   1 
ATOM   86   O O   . SER A 1 39  ? 176.34900 359.30300 38.37500  1.000 42.94968  ? 35  SER F O   1 
ATOM   87   C CB  . SER A 1 39  ? 175.13900 358.06500 41.00900  1.000 47.10592  ? 35  SER F CB  1 
ATOM   88   O OG  . SER A 1 39  ? 175.24100 356.67400 40.83100  1.000 44.94573  ? 35  SER F OG  1 
ATOM   89   N N   . THR A 1 40  ? 175.21100 357.47700 37.78600  1.000 40.98196  ? 36  THR F N   1 
ATOM   90   C CA  . THR A 1 40  ? 176.08600 357.19200 36.66100  1.000 43.71358  ? 36  THR F CA  1 
ATOM   91   C C   . THR A 1 40  ? 175.35100 357.20600 35.32900  1.000 39.65241  ? 36  THR F C   1 
ATOM   92   O O   . THR A 1 40  ? 175.91600 356.77100 34.32000  1.000 40.40648  ? 36  THR F O   1 
ATOM   93   C CB  . THR A 1 40  ? 176.80500 355.85600 36.85600  1.000 44.19333  ? 36  THR F CB  1 
ATOM   94   O OG1 . THR A 1 40  ? 175.84300 354.82800 37.08900  1.000 36.96537  ? 36  THR F OG1 1 
ATOM   95   C CG2 . THR A 1 40  ? 177.68200 355.99000 38.06900  1.000 42.57807  ? 36  THR F CG2 1 
ATOM   96   N N   . CYS A 1 41  ? 174.06600 357.54500 35.31900  1.000 39.97286  ? 37  CYS F N   1 
ATOM   97   C CA  . CYS A 1 41  ? 173.31400 357.59700 34.07300  1.000 34.03032  ? 37  CYS F CA  1 
ATOM   98   C C   . CYS A 1 41  ? 173.40300 356.25600 33.36000  1.000 39.98035  ? 37  CYS F C   1 
ATOM   99   O O   . CYS A 1 41  ? 173.78000 356.18600 32.18100  1.000 36.50646  ? 37  CYS F O   1 
ATOM   100  C CB  . CYS A 1 41  ? 173.83200 358.72300 33.16800  1.000 34.90431  ? 37  CYS F CB  1 
ATOM   101  S SG  . CYS A 1 41  ? 172.73000 359.09700 31.76400  1.000 35.74288  ? 37  CYS F SG  1 
ATOM   102  N N   . SER A 1 42  ? 173.13100 355.17300 34.10900  1.000 38.42775  ? 38  SER F N   1 
ATOM   103  C CA  . SER A 1 42  ? 173.23900 353.83500 33.51000  1.000 41.36367  ? 38  SER F CA  1 
ATOM   104  C C   . SER A 1 42  ? 172.12800 352.97500 34.08600  1.000 41.41436  ? 38  SER F C   1 
ATOM   105  O O   . SER A 1 42  ? 171.51300 353.34500 35.07500  1.000 38.47028  ? 38  SER F O   1 
ATOM   106  C CB  . SER A 1 42  ? 174.58100 353.13800 33.76600  1.000 35.63117  ? 38  SER F CB  1 
ATOM   107  O OG  . SER A 1 42  ? 174.90300 353.15400 35.14900  1.000 42.52550  ? 38  SER F OG  1 
ATOM   108  N N   . ALA A 1 43  ? 171.74300 351.94600 33.35500  1.000 38.55549  ? 39  ALA F N   1 
ATOM   109  C CA  . ALA A 1 43  ? 170.70600 351.00100 33.76400  1.000 37.05000  ? 39  ALA F CA  1 
ATOM   110  C C   . ALA A 1 43  ? 171.12900 349.55600 33.50800  1.000 37.93070  ? 39  ALA F C   1 
ATOM   111  O O   . ALA A 1 43  ? 171.88300 349.27900 32.58300  1.000 39.18147  ? 39  ALA F O   1 
ATOM   112  C CB  . ALA A 1 43  ? 169.35100 351.27600 33.08000  1.000 37.52539  ? 39  ALA F CB  1 
ATOM   113  N N   . VAL A 1 44  ? 170.65300 348.64000 34.34200  1.000 45.02500  ? 40  VAL F N   1 
ATOM   114  C CA  . VAL A 1 44  ? 170.91300 347.20700 34.20300  1.000 40.67678  ? 40  VAL F CA  1 
ATOM   115  C C   . VAL A 1 44  ? 169.58900 346.45400 34.16000  1.000 42.92480  ? 40  VAL F C   1 
ATOM   116  O O   . VAL A 1 44  ? 168.75100 346.60300 35.06100  1.000 46.10256  ? 40  VAL F O   1 
ATOM   117  C CB  . VAL A 1 44  ? 171.80000 346.64300 35.32300  1.000 40.97624  ? 40  VAL F CB  1 
ATOM   118  C CG1 . VAL A 1 44  ? 171.97600 345.18000 35.08000  1.000 41.79228  ? 40  VAL F CG1 1 
ATOM   119  C CG2 . VAL A 1 44  ? 173.18600 347.26800 35.23500  1.000 41.60253  ? 40  VAL F CG2 1 
ATOM   120  N N   . SER A 1 45  ? 169.37400 345.70700 33.06600  1.000 43.17054  ? 41  SER F N   1 
ATOM   121  C CA  . SER A 1 45  ? 168.18900 344.87100 32.86300  1.000 44.21503  ? 41  SER F CA  1 
ATOM   122  C C   . SER A 1 45  ? 168.57200 343.44200 33.27300  1.000 46.93112  ? 41  SER F C   1 
ATOM   123  O O   . SER A 1 45  ? 169.42000 342.82300 32.61000  1.000 48.34352  ? 41  SER F O   1 
ATOM   124  C CB  . SER A 1 45  ? 167.75500 344.88600 31.39500  1.000 43.48203  ? 41  SER F CB  1 
ATOM   125  O OG  . SER A 1 45  ? 167.49100 346.19000 30.93400  1.000 48.95550  ? 41  SER F OG  1 
ATOM   126  N N   . LYS A 1 46  ? 167.99700 342.94700 34.38100  1.000 48.65841  ? 42  LYS F N   1 
ATOM   127  C CA  . LYS A 1 46  ? 168.26900 341.63200 34.95600  1.000 42.79511  ? 42  LYS F CA  1 
ATOM   128  C C   . LYS A 1 46  ? 167.14900 340.61400 34.69800  1.000 50.96055  ? 42  LYS F C   1 
ATOM   129  O O   . LYS A 1 46  ? 166.00000 340.96200 34.38200  1.000 48.33748  ? 42  LYS F O   1 
ATOM   130  C CB  . LYS A 1 46  ? 168.53300 341.73000 36.45900  1.000 46.29127  ? 42  LYS F CB  1 
ATOM   131  C CG  . LYS A 1 46  ? 169.78100 342.53100 36.81100  1.000 52.27395  ? 42  LYS F CG  1 
ATOM   132  C CD  . LYS A 1 46  ? 170.01400 342.70700 38.32600  1.000 54.55608  ? 42  LYS F CD  1 
ATOM   133  C CE  . LYS A 1 46  ? 168.77900 342.98100 39.14300  1.000 63.73661  ? 42  LYS F CE  1 
ATOM   134  N NZ  . LYS A 1 46  ? 169.20700 343.27300 40.55500  1.000 72.66474  ? 42  LYS F NZ  1 
ATOM   135  N N   . GLY A 1 47  ? 167.46900 339.34300 35.00700  1.000 46.45257  ? 43  GLY F N   1 
ATOM   136  C CA  . GLY A 1 47  ? 166.52900 338.23900 34.96800  1.000 43.43567  ? 43  GLY F CA  1 
ATOM   137  C C   . GLY A 1 47  ? 166.62200 337.35700 33.74400  1.000 48.24024  ? 43  GLY F C   1 
ATOM   138  O O   . GLY A 1 47  ? 165.80300 336.43600 33.59500  1.000 49.53832  ? 43  GLY F O   1 
ATOM   139  N N   . TYR A 1 48  ? 167.57600 337.62600 32.85500  1.000 43.67466  ? 44  TYR F N   1 
ATOM   140  C CA  . TYR A 1 48  ? 167.76000 336.88600 31.61100  1.000 45.38671  ? 44  TYR F CA  1 
ATOM   141  C C   . TYR A 1 48  ? 168.58700 335.62800 31.86900  1.000 47.00758  ? 44  TYR F C   1 
ATOM   142  O O   . TYR A 1 48  ? 169.28200 335.53500 32.89100  1.000 43.43780  ? 44  TYR F O   1 
ATOM   143  C CB  . TYR A 1 48  ? 168.43000 337.75100 30.54500  1.000 47.11319  ? 44  TYR F CB  1 
ATOM   144  C CG  . TYR A 1 48  ? 167.52300 338.87600 30.11600  1.000 43.05023  ? 44  TYR F CG  1 
ATOM   145  C CD1 . TYR A 1 48  ? 167.51000 340.04600 30.86100  1.000 40.14677  ? 44  TYR F CD1 1 
ATOM   146  C CD2 . TYR A 1 48  ? 166.62600 338.74600 29.05100  1.000 43.19353  ? 44  TYR F CD2 1 
ATOM   147  C CE1 . TYR A 1 48  ? 166.69600 341.09800 30.54500  1.000 45.74915  ? 44  TYR F CE1 1 
ATOM   148  C CE2 . TYR A 1 48  ? 165.77900 339.80800 28.71000  1.000 44.07933  ? 44  TYR F CE2 1 
ATOM   149  C CZ  . TYR A 1 48  ? 165.82700 340.98900 29.48200  1.000 48.91823  ? 44  TYR F CZ  1 
ATOM   150  O OH  . TYR A 1 48  ? 165.04300 342.09000 29.23000  1.000 54.21874  ? 44  TYR F OH  1 
ATOM   151  N N   . LEU A 1 49  ? 168.26200 334.57400 31.12100  1.000 44.29197  ? 45  LEU F N   1 
ATOM   152  C CA  . LEU A 1 49  ? 168.94400 333.28900 31.13500  1.000 42.35097  ? 45  LEU F CA  1 
ATOM   153  C C   . LEU A 1 49  ? 169.87700 333.11400 29.93600  1.000 44.59983  ? 45  LEU F C   1 
ATOM   154  O O   . LEU A 1 49  ? 169.48300 333.39000 28.80500  1.000 47.54996  ? 45  LEU F O   1 
ATOM   155  C CB  . LEU A 1 49  ? 167.88300 332.18500 31.14000  1.000 46.06524  ? 45  LEU F CB  1 
ATOM   156  C CG  . LEU A 1 49  ? 166.98800 332.23300 32.39300  1.000 53.46242  ? 45  LEU F CG  1 
ATOM   157  C CD1 . LEU A 1 49  ? 165.87900 331.17200 32.32000  1.000 58.56849  ? 45  LEU F CD1 1 
ATOM   158  C CD2 . LEU A 1 49  ? 167.79400 332.08600 33.69000  1.000 49.91139  ? 45  LEU F CD2 1 
ATOM   159  N N   . SER A 1 50  ? 171.05400 332.50900 30.15400  1.000 40.61450  ? 46  SER F N   1 
ATOM   160  C CA  . SER A 1 50  ? 172.06000 332.37100 29.10700  1.000 38.22448  ? 46  SER F CA  1 
ATOM   161  C C   . SER A 1 50  ? 171.82600 331.16200 28.20900  1.000 43.81460  ? 46  SER F C   1 
ATOM   162  O O   . SER A 1 50  ? 171.23300 330.15900 28.61100  1.000 41.55608  ? 46  SER F O   1 
ATOM   163  C CB  . SER A 1 50  ? 173.46200 332.24300 29.71400  1.000 44.38958  ? 46  SER F CB  1 
ATOM   164  O OG  . SER A 1 50  ? 173.64400 330.97500 30.39500  1.000 42.24502  ? 46  SER F OG  1 
ATOM   165  N N   . ALA A 1 51  ? 172.31100 331.27300 26.97300  1.000 39.91091  ? 47  ALA F N   1 
ATOM   166  C CA  . ALA A 1 51  ? 172.62500 330.11600 26.14700  1.000 44.28073  ? 47  ALA F CA  1 
ATOM   167  C C   . ALA A 1 51  ? 173.77300 330.55600 25.24200  1.000 42.54166  ? 47  ALA F C   1 
ATOM   168  O O   . ALA A 1 51  ? 173.57000 331.26200 24.24300  1.000 44.74810  ? 47  ALA F O   1 
ATOM   169  C CB  . ALA A 1 51  ? 171.40500 329.69400 25.33600  1.000 47.84049  ? 47  ALA F CB  1 
ATOM   170  N N   . LEU A 1 52  ? 174.97400 330.22300 25.67500  1.000 39.76811  ? 48  LEU F N   1 
ATOM   171  C CA  . LEU A 1 52  ? 176.21700 330.59500 25.02700  1.000 36.44814  ? 48  LEU F CA  1 
ATOM   172  C C   . LEU A 1 52  ? 176.74400 329.45700 24.16700  1.000 43.24616  ? 48  LEU F C   1 
ATOM   173  O O   . LEU A 1 52  ? 176.84300 328.31900 24.64500  1.000 45.40103  ? 48  LEU F O   1 
ATOM   174  C CB  . LEU A 1 52  ? 177.24900 331.03400 26.06000  1.000 38.13469  ? 48  LEU F CB  1 
ATOM   175  C CG  . LEU A 1 52  ? 176.64800 332.09300 26.99700  1.000 41.58228  ? 48  LEU F CG  1 
ATOM   176  C CD1 . LEU A 1 52  ? 177.75700 332.65000 27.91200  1.000 33.79775  ? 48  LEU F CD1 1 
ATOM   177  C CD2 . LEU A 1 52  ? 175.83500 333.22300 26.28900  1.000 36.39670  ? 48  LEU F CD2 1 
ATOM   178  N N   . ARG A 1 53  ? 177.12200 329.75000 22.92900  1.000 43.09445  ? 49  ARG F N   1 
ATOM   179  C CA  . ARG A 1 53  ? 177.69900 328.71400 22.09300  1.000 43.50028  ? 49  ARG F CA  1 
ATOM   180  C C   . ARG A 1 53  ? 179.15100 328.49500 22.48300  1.000 46.14021  ? 49  ARG F C   1 
ATOM   181  O O   . ARG A 1 53  ? 179.98800 329.40000 22.37000  1.000 45.88683  ? 49  ARG F O   1 
ATOM   182  C CB  . ARG A 1 53  ? 177.66500 329.06500 20.61100  1.000 44.89216  ? 49  ARG F CB  1 
ATOM   183  C CG  . ARG A 1 53  ? 177.69500 327.80400 19.74500  1.000 40.36886  ? 49  ARG F CG  1 
ATOM   184  C CD  . ARG A 1 53  ? 178.41000 328.04100 18.39700  1.000 43.95147  ? 49  ARG F CD  1 
ATOM   185  N NE  . ARG A 1 53  ? 179.61700 328.85300 18.47100  1.000 45.06768  ? 49  ARG F NE  1 
ATOM   186  C CZ  . ARG A 1 53  ? 180.84200 328.37500 18.68200  1.000 49.35895  ? 49  ARG F CZ  1 
ATOM   187  N NH1 . ARG A 1 53  ? 181.06000 327.08100 18.88300  1.000 46.02022  ? 49  ARG F NH1 1 
ATOM   188  N NH2 . ARG A 1 53  ? 181.87700 329.21600 18.68400  1.000 40.94905  ? 49  ARG F NH2 1 
ATOM   189  N N   . THR A 1 54  ? 179.45800 327.25100 22.79700  1.000 44.64602  ? 50  THR F N   1 
ATOM   190  C CA  . THR A 1 54  ? 180.78100 326.82200 23.19400  1.000 46.91422  ? 50  THR F CA  1 
ATOM   191  C C   . THR A 1 54  ? 181.28800 325.71200 22.31100  1.000 49.92733  ? 50  THR F C   1 
ATOM   192  O O   . THR A 1 54  ? 182.50600 325.50600 22.25800  1.000 58.39248  ? 50  THR F O   1 
ATOM   193  C CB  . THR A 1 54  ? 180.78500 326.34500 24.65600  1.000 44.56962  ? 50  THR F CB  1 
ATOM   194  O OG1 . THR A 1 54  ? 179.90900 325.22800 24.78400  1.000 41.10666  ? 50  THR F OG1 1 
ATOM   195  C CG2 . THR A 1 54  ? 180.31700 327.45100 25.61200  1.000 44.50096  ? 50  THR F CG2 1 
ATOM   196  N N   . GLY A 1 55  ? 180.41500 325.06300 21.53100  1.000 49.39520  ? 51  GLY F N   1 
ATOM   197  C CA  . GLY A 1 55  ? 180.86000 323.99600 20.66400  1.000 51.19646  ? 51  GLY F CA  1 
ATOM   198  C C   . GLY A 1 55  ? 180.12800 323.98500 19.33600  1.000 52.86501  ? 51  GLY F C   1 
ATOM   199  O O   . GLY A 1 55  ? 179.22600 324.78600 19.08400  1.000 55.80475  ? 51  GLY F O   1 
ATOM   200  N N   . TRP A 1 56  ? 180.56700 323.08200 18.47700  1.000 47.25270  ? 52  TRP F N   1 
ATOM   201  C CA  . TRP A 1 56  ? 179.98800 322.88400 17.15900  1.000 51.01370  ? 52  TRP F CA  1 
ATOM   202  C C   . TRP A 1 56  ? 179.61700 321.41900 16.98700  1.000 56.82863  ? 52  TRP F C   1 
ATOM   203  O O   . TRP A 1 56  ? 180.32600 320.52800 17.46800  1.000 58.06063  ? 52  TRP F O   1 
ATOM   204  C CB  . TRP A 1 56  ? 180.91200 323.31400 16.02100  1.000 50.46131  ? 52  TRP F CB  1 
ATOM   205  C CG  . TRP A 1 56  ? 181.17600 324.77800 15.95300  1.000 51.39708  ? 52  TRP F CG  1 
ATOM   206  C CD1 . TRP A 1 56  ? 182.33800 325.41700 16.23300  1.000 52.38380  ? 52  TRP F CD1 1 
ATOM   207  C CD2 . TRP A 1 56  ? 180.23400 325.79400 15.58700  1.000 46.49158  ? 52  TRP F CD2 1 
ATOM   208  N NE1 . TRP A 1 56  ? 182.19500 326.76600 16.03800  1.000 49.90973  ? 52  TRP F NE1 1 
ATOM   209  C CE2 . TRP A 1 56  ? 180.90900 327.02800 15.65000  1.000 51.51991  ? 52  TRP F CE2 1 
ATOM   210  C CE3 . TRP A 1 56  ? 178.88400 325.77900 15.20600  1.000 48.74344  ? 52  TRP F CE3 1 
ATOM   211  C CZ2 . TRP A 1 56  ? 180.28500 328.24600 15.34700  1.000 48.46996  ? 52  TRP F CZ2 1 
ATOM   212  C CZ3 . TRP A 1 56  ? 178.25700 326.99500 14.91200  1.000 49.76406  ? 52  TRP F CZ3 1 
ATOM   213  C CH2 . TRP A 1 56  ? 178.96400 328.21000 14.98300  1.000 47.48286  ? 52  TRP F CH2 1 
ATOM   214  N N   . TYR A 1 57  ? 178.49800 321.16200 16.32400  1.000 53.82078  ? 53  TYR F N   1 
ATOM   215  C CA  . TYR A 1 57  ? 178.15100 319.79900 15.96200  1.000 56.54227  ? 53  TYR F CA  1 
ATOM   216  C C   . TYR A 1 57  ? 178.08700 319.76600 14.43400  1.000 58.75812  ? 53  TYR F C   1 
ATOM   217  O O   . TYR A 1 57  ? 177.32300 320.53200 13.83300  1.000 55.65729  ? 53  TYR F O   1 
ATOM   218  C CB  . TYR A 1 57  ? 176.82900 319.33200 16.56600  1.000 56.29372  ? 53  TYR F CB  1 
ATOM   219  C CG  . TYR A 1 57  ? 176.54900 317.93000 16.07000  1.000 66.76204  ? 53  TYR F CG  1 
ATOM   220  C CD1 . TYR A 1 57  ? 177.15700 316.84700 16.70900  1.000 67.70845  ? 53  TYR F CD1 1 
ATOM   221  C CD2 . TYR A 1 57  ? 175.77900 317.67200 14.93900  1.000 67.51532  ? 53  TYR F CD2 1 
ATOM   222  C CE1 . TYR A 1 57  ? 176.96600 315.54800 16.28600  1.000 70.79685  ? 53  TYR F CE1 1 
ATOM   223  C CE2 . TYR A 1 57  ? 175.58000 316.35800 14.49700  1.000 69.76350  ? 53  TYR F CE2 1 
ATOM   224  C CZ  . TYR A 1 57  ? 176.18400 315.30000 15.18100  1.000 76.32741  ? 53  TYR F CZ  1 
ATOM   225  O OH  . TYR A 1 57  ? 176.01300 313.98700 14.78100  1.000 80.04268  ? 53  TYR F OH  1 
ATOM   226  N N   . THR A 1 58  ? 179.02000 319.07600 13.78800  1.000 52.82960  ? 54  THR F N   1 
ATOM   227  C CA  . THR A 1 58  ? 178.97300 319.06900 12.33500  1.000 61.97642  ? 54  THR F CA  1 
ATOM   228  C C   . THR A 1 58  ? 178.18300 317.86200 11.83500  1.000 64.75177  ? 54  THR F C   1 
ATOM   229  O O   . THR A 1 58  ? 178.21900 316.78500 12.42800  1.000 68.25780  ? 54  THR F O   1 
ATOM   230  C CB  . THR A 1 58  ? 180.37500 319.00500 11.76400  1.000 56.20293  ? 54  THR F CB  1 
ATOM   231  O OG1 . THR A 1 58  ? 180.96000 317.79100 12.20300  1.000 63.11650  ? 54  THR F OG1 1 
ATOM   232  C CG2 . THR A 1 58  ? 181.18700 320.13000 12.33900  1.000 57.23972  ? 54  THR F CG2 1 
ATOM   233  N N   . SER A 1 59  ? 177.54600 318.01700 10.68200  1.000 66.86806  ? 55  SER F N   1 
ATOM   234  C CA  . SER A 1 59  ? 176.79200 316.90600 10.11100  1.000 66.41779  ? 55  SER F CA  1 
ATOM   235  C C   . SER A 1 59  ? 176.87600 317.02000 8.59900   1.000 65.40117  ? 55  SER F C   1 
ATOM   236  O O   . SER A 1 59  ? 176.90100 318.13100 8.06000   1.000 64.43451  ? 55  SER F O   1 
ATOM   237  C CB  . SER A 1 59  ? 175.34200 316.86100 10.59600  1.000 63.43773  ? 55  SER F CB  1 
ATOM   238  O OG  . SER A 1 59  ? 174.65000 318.03100 10.24700  1.000 75.85222  ? 55  SER F OG  1 
ATOM   239  N N   . VAL A 1 60  ? 176.97800 315.88100 7.92200   1.000 66.06634  ? 56  VAL F N   1 
ATOM   240  C CA  . VAL A 1 60  ? 177.13000 315.88600 6.47100   1.000 65.29554  ? 56  VAL F CA  1 
ATOM   241  C C   . VAL A 1 60  ? 175.76200 315.72600 5.80900   1.000 64.59765  ? 56  VAL F C   1 
ATOM   242  O O   . VAL A 1 60  ? 174.97300 314.84900 6.18300   1.000 65.30330  ? 56  VAL F O   1 
ATOM   243  C CB  . VAL A 1 60  ? 178.12900 314.80700 6.02600   1.000 64.29573  ? 56  VAL F CB  1 
ATOM   244  C CG1 . VAL A 1 60  ? 178.22400 314.75300 4.51800   1.000 59.39866  ? 56  VAL F CG1 1 
ATOM   245  C CG2 . VAL A 1 60  ? 179.49700 315.09900 6.63700   1.000 63.48923  ? 56  VAL F CG2 1 
ATOM   246  N N   . ILE A 1 61  ? 175.46800 316.61700 4.86200   1.000 60.45737  ? 57  ILE F N   1 
ATOM   247  C CA  . ILE A 1 61  ? 174.24300 316.63600 4.07200   1.000 62.95924  ? 57  ILE F CA  1 
ATOM   248  C C   . ILE A 1 61  ? 174.64300 316.33900 2.63100   1.000 65.11406  ? 57  ILE F C   1 
ATOM   249  O O   . ILE A 1 61  ? 175.54200 316.99400 2.08100   1.000 64.10460  ? 57  ILE F O   1 
ATOM   250  C CB  . ILE A 1 61  ? 173.51300 317.98900 4.16100   1.000 65.13756  ? 57  ILE F CB  1 
ATOM   251  C CG1 . ILE A 1 61  ? 173.38500 318.49900 5.60300   1.000 62.27798  ? 57  ILE F CG1 1 
ATOM   252  C CG2 . ILE A 1 61  ? 172.13300 317.89500 3.52900   1.000 66.27821  ? 57  ILE F CG2 1 
ATOM   253  C CD1 . ILE A 1 61  ? 172.61200 317.60100 6.50800   1.000 59.94673  ? 57  ILE F CD1 1 
ATOM   254  N N   . THR A 1 62  ? 174.12200 315.23500 2.10500   1.000 66.31717  ? 58  THR F N   1 
ATOM   255  C CA  . THR A 1 62  ? 174.39600 314.70700 0.77600   1.000 66.23746  ? 58  THR F CA  1 
ATOM   256  C C   . THR A 1 62  ? 173.21200 314.80600 -0.18100  1.000 65.40924  ? 58  THR F C   1 
ATOM   257  O O   . THR A 1 62  ? 172.02900 314.75700 0.21100   1.000 59.64865  ? 58  THR F O   1 
ATOM   258  C CB  . THR A 1 62  ? 174.84700 313.25100 0.85700   1.000 67.54036  ? 58  THR F CB  1 
ATOM   259  O OG1 . THR A 1 62  ? 173.73300 312.43400 1.24400   1.000 65.02259  ? 58  THR F OG1 1 
ATOM   260  C CG2 . THR A 1 62  ? 175.99800 313.11800 1.86100   1.000 69.22236  ? 58  THR F CG2 1 
ATOM   261  N N   . ILE A 1 63  ? 173.56800 314.95100 -1.45200  1.000 63.00268  ? 59  ILE F N   1 
ATOM   262  C CA  . ILE A 1 63  ? 172.62900 314.90200 -2.55900  1.000 65.21480  ? 59  ILE F CA  1 
ATOM   263  C C   . ILE A 1 63  ? 173.18700 313.92300 -3.58300  1.000 65.41210  ? 59  ILE F C   1 
ATOM   264  O O   . ILE A 1 63  ? 174.28700 314.13100 -4.11700  1.000 63.17431  ? 59  ILE F O   1 
ATOM   265  C CB  . ILE A 1 63  ? 172.39600 316.27900 -3.18700  1.000 65.45053  ? 59  ILE F CB  1 
ATOM   266  C CG1 . ILE A 1 63  ? 171.62400 317.16400 -2.21400  1.000 61.34821  ? 59  ILE F CG1 1 
ATOM   267  C CG2 . ILE A 1 63  ? 171.65900 316.14300 -4.51300  1.000 65.72786  ? 59  ILE F CG2 1 
ATOM   268  C CD1 . ILE A 1 63  ? 171.30100 318.50400 -2.77900  1.000 55.37351  ? 59  ILE F CD1 1 
ATOM   269  N N   . GLU A 1 64  ? 172.46300 312.82600 -3.79700  1.000 71.72330  ? 60  GLU F N   1 
ATOM   270  C CA  . GLU A 1 64  ? 172.86100 311.76600 -4.72600  1.000 75.03221  ? 60  GLU F CA  1 
ATOM   271  C C   . GLU A 1 64  ? 172.65600 312.28200 -6.14900  1.000 71.16752  ? 60  GLU F C   1 
ATOM   272  O O   . GLU A 1 64  ? 171.53200 312.59400 -6.55600  1.000 71.01822  ? 60  GLU F O   1 
ATOM   273  C CB  . GLU A 1 64  ? 172.09600 310.47400 -4.44900  1.000 76.75736  ? 60  GLU F CB  1 
ATOM   274  C CG  . GLU A 1 64  ? 172.90200 309.23200 -4.83100  1.000 82.67622  ? 60  GLU F CG  1 
ATOM   275  C CD  . GLU A 1 64  ? 172.30900 307.92200 -4.31000  1.000 87.97376  ? 60  GLU F CD  1 
ATOM   276  O OE1 . GLU A 1 64  ? 171.21800 307.94100 -3.68300  1.000 82.68390  ? 60  GLU F OE1 1 
ATOM   277  O OE2 . GLU A 1 64  ? 172.94100 306.86500 -4.54900  1.000 88.46205  ? 60  GLU F OE2 1 
ATOM   278  N N   . LEU A 1 65  ? 173.74200 312.42700 -6.88300  1.000 68.68890  ? 61  LEU F N   1 
ATOM   279  C CA  . LEU A 1 65  ? 173.71300 312.97800 -8.22400  1.000 70.74285  ? 61  LEU F CA  1 
ATOM   280  C C   . LEU A 1 65  ? 173.83600 311.90800 -9.30200  1.000 78.37326  ? 61  LEU F C   1 
ATOM   281  O O   . LEU A 1 65  ? 174.20700 310.75600 -9.05900  1.000 79.34020  ? 61  LEU F O   1 
ATOM   282  C CB  . LEU A 1 65  ? 174.85300 313.98600 -8.37400  1.000 72.86205  ? 61  LEU F CB  1 
ATOM   283  C CG  . LEU A 1 65  ? 174.52500 315.47600 -8.38300  1.000 67.14646  ? 61  LEU F CG  1 
ATOM   284  C CD1 . LEU A 1 65  ? 173.59300 315.82700 -7.26400  1.000 59.55361  ? 61  LEU F CD1 1 
ATOM   285  C CD2 . LEU A 1 65  ? 175.83200 316.22200 -8.22400  1.000 68.41835  ? 61  LEU F CD2 1 
ATOM   286  N N   . SER A 1 66  ? 173.56200 312.34000 -10.52600 1.000 76.62209  ? 62  SER F N   1 
ATOM   287  C CA  . SER A 1 66  ? 173.58500 311.50700 -11.71600 1.000 81.52124  ? 62  SER F CA  1 
ATOM   288  C C   . SER A 1 66  ? 174.77200 311.96100 -12.53700 1.000 84.65375  ? 62  SER F C   1 
ATOM   289  O O   . SER A 1 66  ? 174.84200 313.12700 -12.94200 1.000 84.02854  ? 62  SER F O   1 
ATOM   290  C CB  . SER A 1 66  ? 172.28600 311.63900 -12.51600 1.000 84.79768  ? 62  SER F CB  1 
ATOM   291  O OG  . SER A 1 66  ? 172.25200 310.76900 -13.63700 1.000 87.40354  ? 62  SER F OG  1 
ATOM   292  N N   . ASN A 1 67  ? 175.69800 311.03700 -12.77400 1.000 91.25416  ? 63  ASN F N   1 
ATOM   293  C CA  . ASN A 1 67  ? 176.89600 311.28400 -13.56300 1.000 94.85242  ? 63  ASN F CA  1 
ATOM   294  C C   . ASN A 1 67  ? 176.61100 311.23700 -15.03200 1.000 98.57159  ? 63  ASN F C   1 
ATOM   295  O O   . ASN A 1 67  ? 177.53900 311.11900 -15.84600 1.000 101.93284 ? 63  ASN F O   1 
ATOM   296  C CB  . ASN A 1 67  ? 177.97400 310.25200 -13.20700 1.000 97.14222  ? 63  ASN F CB  1 
ATOM   297  C CG  . ASN A 1 67  ? 177.53400 308.82000 -13.50400 1.000 100.31441 ? 63  ASN F CG  1 
ATOM   298  O OD1 . ASN A 1 67  ? 176.33900 308.50200 -13.49400 1.000 99.91804  ? 63  ASN F OD1 1 
ATOM   299  N ND2 . ASN A 1 67  ? 178.50600 307.94700 -13.76300 1.000 100.99372 ? 63  ASN F ND2 1 
ATOM   300  N N   . ILE A 1 68  ? 175.32400 311.34000 -15.37300 1.000 96.96191  ? 64  ILE F N   1 
ATOM   301  C CA  . ILE A 1 68  ? 174.91700 311.31700 -16.76200 1.000 100.85866 ? 64  ILE F CA  1 
ATOM   302  C C   . ILE A 1 68  ? 175.64300 312.41900 -17.51200 1.000 102.72012 ? 64  ILE F C   1 
ATOM   303  O O   . ILE A 1 68  ? 176.01900 313.45400 -16.94600 1.000 103.45446 ? 64  ILE F O   1 
ATOM   304  C CB  . ILE A 1 68  ? 173.39300 311.49200 -16.88000 1.000 99.12803  ? 64  ILE F CB  1 
ATOM   305  C CG1 . ILE A 1 68  ? 172.98100 311.72100 -18.33500 1.000 98.99445  ? 64  ILE F CG1 1 
ATOM   306  C CG2 . ILE A 1 68  ? 172.92200 312.65400 -16.02600 1.000 94.28610  ? 64  ILE F CG2 1 
ATOM   307  C CD1 . ILE A 1 68  ? 171.51400 311.52300 -18.57500 1.000 98.54383  ? 64  ILE F CD1 1 
ATOM   308  N N   . LYS A 1 69  ? 175.82800 312.19600 -18.80000 1.000 105.78838 ? 65  LYS F N   1 
ATOM   309  C CA  . LYS A 1 69  ? 176.38400 313.17600 -19.70800 1.000 109.04455 ? 65  LYS F CA  1 
ATOM   310  C C   . LYS A 1 69  ? 175.29400 313.53600 -20.70300 1.000 115.09468 ? 65  LYS F C   1 
ATOM   311  O O   . LYS A 1 69  ? 174.29700 312.82000 -20.83800 1.000 116.79084 ? 65  LYS F O   1 
ATOM   312  C CB  . LYS A 1 69  ? 177.64200 312.62800 -20.39100 1.000 109.79792 ? 65  LYS F CB  1 
ATOM   313  C CG  . LYS A 1 69  ? 178.73500 312.30300 -19.37500 1.000 109.64115 ? 65  LYS F CG  1 
ATOM   314  C CD  . LYS A 1 69  ? 179.52900 311.05100 -19.69600 1.000 105.02160 ? 65  LYS F CD  1 
ATOM   315  C CE  . LYS A 1 69  ? 180.33500 310.62800 -18.46900 1.000 103.65088 ? 65  LYS F CE  1 
ATOM   316  N NZ  . LYS A 1 69  ? 181.49900 309.75600 -18.79100 1.000 101.66806 ? 65  LYS F NZ  1 
ATOM   317  N N   . GLU A 1 70  ? 175.48200 314.65100 -21.40200 1.000 114.72004 ? 66  GLU F N   1 
ATOM   318  C CA  . GLU A 1 70  ? 174.42500 315.13000 -22.28100 1.000 119.45271 ? 66  GLU F CA  1 
ATOM   319  C C   . GLU A 1 70  ? 174.19500 314.11700 -23.39100 1.000 122.27135 ? 66  GLU F C   1 
ATOM   320  O O   . GLU A 1 70  ? 175.14200 313.55200 -23.95000 1.000 122.05004 ? 66  GLU F O   1 
ATOM   321  C CB  . GLU A 1 70  ? 174.75100 316.51200 -22.86200 1.000 121.60770 ? 66  GLU F CB  1 
ATOM   322  C CG  . GLU A 1 70  ? 173.58500 317.11900 -23.67300 1.000 120.93095 ? 66  GLU F CG  1 
ATOM   323  C CD  . GLU A 1 70  ? 173.82300 318.56700 -24.10200 1.000 122.69771 ? 66  GLU F CD  1 
ATOM   324  O OE1 . GLU A 1 70  ? 174.85000 319.15200 -23.69400 1.000 123.21803 ? 66  GLU F OE1 1 
ATOM   325  O OE2 . GLU A 1 70  ? 172.96700 319.12900 -24.82700 1.000 120.94201 ? 66  GLU F OE2 1 
ATOM   326  N N   . ASN A 1 71  ? 172.92500 313.88200 -23.70700 1.000 121.08196 ? 67  ASN F N   1 
ATOM   327  C CA  . ASN A 1 71  ? 172.59600 312.96300 -24.77800 1.000 123.20598 ? 67  ASN F CA  1 
ATOM   328  C C   . ASN A 1 71  ? 171.67000 313.67300 -25.74500 1.000 121.28300 ? 67  ASN F C   1 
ATOM   329  O O   . ASN A 1 71  ? 170.70200 314.33200 -25.35100 1.000 118.49395 ? 67  ASN F O   1 
ATOM   330  C CB  . ASN A 1 71  ? 171.89500 311.70000 -24.23700 1.000 121.43800 ? 67  ASN F CB  1 
ATOM   331  C CG  . ASN A 1 71  ? 172.86800 310.66000 -23.71000 1.000 122.79828 ? 67  ASN F CG  1 
ATOM   332  O OD1 . ASN A 1 71  ? 173.91300 310.40500 -24.30700 1.000 127.24112 ? 67  ASN F OD1 1 
ATOM   333  N ND2 . ASN A 1 71  ? 172.52500 310.05500 -22.57700 1.000 119.19615 ? 67  ASN F ND2 1 
ATOM   334  N N   . LYS A 1 72  ? 171.97400 313.48300 -27.01900 1.000 121.54730 ? 68  LYS F N   1 
ATOM   335  C CA  . LYS A 1 72  ? 171.24800 314.06600 -28.12800 1.000 125.48243 ? 68  LYS F CA  1 
ATOM   336  C C   . LYS A 1 72  ? 170.63500 312.96600 -28.97000 1.000 128.53055 ? 68  LYS F C   1 
ATOM   337  O O   . LYS A 1 72  ? 171.33600 312.04300 -29.39800 1.000 129.21775 ? 68  LYS F O   1 
ATOM   338  C CB  . LYS A 1 72  ? 172.18000 314.91800 -29.00700 1.000 126.08008 ? 68  LYS F CB  1 
ATOM   339  C CG  . LYS A 1 72  ? 171.48900 315.67900 -30.14000 1.000 123.33572 ? 68  LYS F CG  1 
ATOM   340  C CD  . LYS A 1 72  ? 172.50100 316.10400 -31.21000 1.000 120.17329 ? 68  LYS F CD  1 
ATOM   341  C CE  . LYS A 1 72  ? 171.95100 315.81800 -32.61100 1.000 118.04278 ? 68  LYS F CE  1 
ATOM   342  N NZ  . LYS A 1 72  ? 172.84700 316.24300 -33.72200 1.000 107.38761 ? 68  LYS F NZ  1 
ATOM   343  N N   . CYS A 1 73  ? 169.33100 313.03900 -29.17400 1.000 127.85563 ? 69  CYS F N   1 
ATOM   344  C CA  . CYS A 1 73  ? 168.68500 312.11800 -30.08500 1.000 130.07430 ? 69  CYS F CA  1 
ATOM   345  C C   . CYS A 1 73  ? 167.77600 312.96800 -30.96400 1.000 129.51586 ? 69  CYS F C   1 
ATOM   346  O O   . CYS A 1 73  ? 167.55500 314.15100 -30.68400 1.000 124.69523 ? 69  CYS F O   1 
ATOM   347  C CB  . CYS A 1 73  ? 167.94700 311.00800 -29.31100 1.000 125.25399 ? 69  CYS F CB  1 
ATOM   348  S SG  . CYS A 1 73  ? 167.07800 311.53600 -27.78600 1.000 126.15303 ? 69  CYS F SG  1 
ATOM   349  N N   . ASN A 1 74  ? 167.25500 312.39100 -32.05000 1.000 131.30774 ? 70  ASN F N   1 
ATOM   350  C CA  . ASN A 1 74  ? 166.31500 313.18200 -32.83600 1.000 130.35426 ? 70  ASN F CA  1 
ATOM   351  C C   . ASN A 1 74  ? 165.13000 313.56800 -31.96000 1.000 124.83625 ? 70  ASN F C   1 
ATOM   352  O O   . ASN A 1 74  ? 164.32100 312.69800 -31.60900 1.000 123.26961 ? 70  ASN F O   1 
ATOM   353  C CB  . ASN A 1 74  ? 165.87400 312.40700 -34.08100 1.000 131.85392 ? 70  ASN F CB  1 
ATOM   354  C CG  . ASN A 1 74  ? 166.92500 312.41700 -35.18200 1.000 131.75383 ? 70  ASN F CG  1 
ATOM   355  O OD1 . ASN A 1 74  ? 167.91200 313.15600 -35.11800 1.000 133.21884 ? 70  ASN F OD1 1 
ATOM   356  N ND2 . ASN A 1 74  ? 166.71100 311.59500 -36.20600 1.000 130.19289 ? 70  ASN F ND2 1 
ATOM   357  N N   . GLY A 1 75  ? 165.04100 314.82200 -31.54400 1.000 118.24333 ? 71  GLY F N   1 
ATOM   358  C CA  . GLY A 1 75  ? 163.92200 315.26900 -30.73100 1.000 108.28761 ? 71  GLY F CA  1 
ATOM   359  C C   . GLY A 1 75  ? 163.30700 316.59400 -31.11400 1.000 103.28181 ? 71  GLY F C   1 
ATOM   360  O O   . GLY A 1 75  ? 164.01400 317.55500 -31.40900 1.000 103.45271 ? 71  GLY F O   1 
ATOM   361  N N   . THR A 1 76  ? 161.99400 316.63400 -31.13200 1.000 97.49448  ? 72  THR F N   1 
ATOM   362  C CA  . THR A 1 76  ? 161.36100 317.89900 -31.46200 1.000 90.57508  ? 72  THR F CA  1 
ATOM   363  C C   . THR A 1 76  ? 160.08900 318.07100 -30.66000 1.000 86.39546  ? 72  THR F C   1 
ATOM   364  O O   . THR A 1 76  ? 159.55000 319.18100 -30.61500 1.000 88.89595  ? 72  THR F O   1 
ATOM   365  C CB  . THR A 1 76  ? 161.02400 318.03900 -32.93700 1.000 91.57606  ? 72  THR F CB  1 
ATOM   366  O OG1 . THR A 1 76  ? 161.23800 319.40300 -33.30800 1.000 93.54654  ? 72  THR F OG1 1 
ATOM   367  C CG2 . THR A 1 76  ? 159.53400 317.90400 -33.12800 1.000 91.01729  ? 72  THR F CG2 1 
ATOM   368  N N   . ASP A 1 77  ? 159.53200 316.98000 -30.12600 1.000 77.03033  ? 73  ASP F N   1 
ATOM   369  C CA  . ASP A 1 77  ? 158.26900 317.06700 -29.42000 1.000 78.34201  ? 73  ASP F CA  1 
ATOM   370  C C   . ASP A 1 77  ? 158.42600 317.95000 -28.19600 1.000 78.80641  ? 73  ASP F C   1 
ATOM   371  O O   . ASP A 1 77  ? 159.48600 317.98500 -27.57100 1.000 77.09731  ? 73  ASP F O   1 
ATOM   372  C CB  . ASP A 1 77  ? 157.83800 315.64400 -29.02300 1.000 76.34521  ? 73  ASP F CB  1 
ATOM   373  C CG  . ASP A 1 77  ? 157.03500 315.59000 -27.72800 1.000 78.97753  ? 73  ASP F CG  1 
ATOM   374  O OD1 . ASP A 1 77  ? 155.79300 315.74800 -27.73500 1.000 79.29030  ? 73  ASP F OD1 1 
ATOM   375  O OD2 . ASP A 1 77  ? 157.67200 315.37400 -26.67600 1.000 79.32312  ? 73  ASP F OD2 1 
ATOM   376  N N   . ALA A 1 78  ? 157.35600 318.67700 -27.85900 1.000 74.32900  ? 74  ALA F N   1 
ATOM   377  C CA  . ALA A 1 78  ? 157.53000 319.74700 -26.88700 1.000 71.62289  ? 74  ALA F CA  1 
ATOM   378  C C   . ALA A 1 78  ? 157.95300 319.22900 -25.51000 1.000 71.33058  ? 74  ALA F C   1 
ATOM   379  O O   . ALA A 1 78  ? 158.68900 319.91400 -24.78000 1.000 70.73940  ? 74  ALA F O   1 
ATOM   380  C CB  . ALA A 1 78  ? 156.22800 320.54300 -26.79200 1.000 67.49166  ? 74  ALA F CB  1 
ATOM   381  N N   . LYS A 1 79  ? 157.53600 318.00200 -25.16400 1.000 70.07939  ? 75  LYS F N   1 
ATOM   382  C CA  . LYS A 1 79  ? 157.85100 317.42800 -23.85700 1.000 68.56903  ? 75  LYS F CA  1 
ATOM   383  C C   . LYS A 1 79  ? 159.32600 317.07000 -23.75700 1.000 71.79966  ? 75  LYS F C   1 
ATOM   384  O O   . LYS A 1 79  ? 159.97300 317.27900 -22.71700 1.000 72.79668  ? 75  LYS F O   1 
ATOM   385  C CB  . LYS A 1 79  ? 156.93300 316.23800 -23.54700 1.000 68.26648  ? 75  LYS F CB  1 
ATOM   386  C CG  . LYS A 1 79  ? 155.53600 316.69500 -23.05500 1.000 60.43016  ? 75  LYS F CG  1 
ATOM   387  C CD  . LYS A 1 79  ? 154.58400 315.54300 -22.67600 1.000 71.02069  ? 75  LYS F CD  1 
ATOM   388  C CE  . LYS A 1 79  ? 154.17600 314.62000 -23.84800 1.000 70.53497  ? 75  LYS F CE  1 
ATOM   389  N NZ  . LYS A 1 79  ? 153.60800 315.37700 -24.99600 1.000 72.20847  ? 75  LYS F NZ  1 
ATOM   390  N N   . VAL A 1 80  ? 159.88700 316.60900 -24.86900 1.000 70.24196  ? 76  VAL F N   1 
ATOM   391  C CA  . VAL A 1 80  ? 161.30400 316.30000 -24.91100 1.000 72.70741  ? 76  VAL F CA  1 
ATOM   392  C C   . VAL A 1 80  ? 162.10100 317.57700 -24.76600 1.000 69.38507  ? 76  VAL F C   1 
ATOM   393  O O   . VAL A 1 80  ? 163.11700 317.60600 -24.06600 1.000 70.51156  ? 76  VAL F O   1 
ATOM   394  C CB  . VAL A 1 80  ? 161.65000 315.54100 -26.20500 1.000 72.35188  ? 76  VAL F CB  1 
ATOM   395  C CG1 . VAL A 1 80  ? 163.16600 315.39600 -26.37600 1.000 69.19572  ? 76  VAL F CG1 1 
ATOM   396  C CG2 . VAL A 1 80  ? 160.96800 314.16700 -26.21700 1.000 71.85055  ? 76  VAL F CG2 1 
ATOM   397  N N   . LYS A 1 81  ? 161.64700 318.65800 -25.40400 1.000 63.08672  ? 77  LYS F N   1 
ATOM   398  C CA  . LYS A 1 81  ? 162.35100 319.92100 -25.25300 1.000 72.17445  ? 77  LYS F CA  1 
ATOM   399  C C   . LYS A 1 81  ? 162.35500 320.38200 -23.79600 1.000 73.91833  ? 77  LYS F C   1 
ATOM   400  O O   . LYS A 1 81  ? 163.39100 320.80900 -23.27300 1.000 74.31706  ? 77  LYS F O   1 
ATOM   401  C CB  . LYS A 1 81  ? 161.68100 321.00700 -26.09400 1.000 74.05134  ? 77  LYS F CB  1 
ATOM   402  C CG  . LYS A 1 81  ? 162.58800 322.18400 -26.31000 1.000 82.86570  ? 77  LYS F CG  1 
ATOM   403  C CD  . LYS A 1 81  ? 161.85000 323.36900 -26.93100 1.000 85.85648  ? 77  LYS F CD  1 
ATOM   404  C CE  . LYS A 1 81  ? 162.78300 324.58800 -27.01000 1.000 88.52399  ? 77  LYS F CE  1 
ATOM   405  N NZ  . LYS A 1 81  ? 162.06200 325.85900 -27.41200 1.000 90.42218  ? 77  LYS F NZ  1 
ATOM   406  N N   . LEU A 1 82  ? 161.21800 320.27000 -23.11100 1.000 70.85971  ? 78  LEU F N   1 
ATOM   407  C CA  . LEU A 1 82  ? 161.16900 320.73400 -21.72900 1.000 69.33465  ? 78  LEU F CA  1 
ATOM   408  C C   . LEU A 1 82  ? 162.11300 319.90200 -20.85300 1.000 71.37759  ? 78  LEU F C   1 
ATOM   409  O O   . LEU A 1 82  ? 162.84300 320.43900 -20.00100 1.000 68.88090  ? 78  LEU F O   1 
ATOM   410  C CB  . LEU A 1 82  ? 159.72600 320.65200 -21.24200 1.000 64.85258  ? 78  LEU F CB  1 
ATOM   411  C CG  . LEU A 1 82  ? 158.84800 321.71200 -21.92300 1.000 69.68915  ? 78  LEU F CG  1 
ATOM   412  C CD1 . LEU A 1 82  ? 157.35700 321.49100 -21.63500 1.000 57.90080  ? 78  LEU F CD1 1 
ATOM   413  C CD2 . LEU A 1 82  ? 159.27900 323.11600 -21.58200 1.000 71.63939  ? 78  LEU F CD2 1 
ATOM   414  N N   . ILE A 1 83  ? 162.14900 318.58700 -21.09100 1.000 69.28001  ? 79  ILE F N   1 
ATOM   415  C CA  . ILE A 1 83  ? 163.03900 317.72300 -20.32100 1.000 65.05095  ? 79  ILE F CA  1 
ATOM   416  C C   . ILE A 1 83  ? 164.49600 318.08100 -20.57500 1.000 69.51660  ? 79  ILE F C   1 
ATOM   417  O O   . ILE A 1 83  ? 165.29000 318.16700 -19.63500 1.000 71.12268  ? 79  ILE F O   1 
ATOM   418  C CB  . ILE A 1 83  ? 162.76400 316.24400 -20.61700 1.000 65.19011  ? 79  ILE F CB  1 
ATOM   419  C CG1 . ILE A 1 83  ? 161.56400 315.77200 -19.81100 1.000 69.65627  ? 79  ILE F CG1 1 
ATOM   420  C CG2 . ILE A 1 83  ? 163.96800 315.40900 -20.25800 1.000 68.76310  ? 79  ILE F CG2 1 
ATOM   421  C CD1 . ILE A 1 83  ? 161.73900 315.87600 -18.31700 1.000 67.35121  ? 79  ILE F CD1 1 
ATOM   422  N N   . LYS A 1 84  ? 164.88200 318.26400 -21.84400 1.000 68.41276  ? 80  LYS F N   1 
ATOM   423  C CA  . LYS A 1 84  ? 166.27700 318.61000 -22.13600 1.000 72.24401  ? 80  LYS F CA  1 
ATOM   424  C C   . LYS A 1 84  ? 166.67200 319.97100 -21.57400 1.000 71.10288  ? 80  LYS F C   1 
ATOM   425  O O   . LYS A 1 84  ? 167.81800 320.15500 -21.14900 1.000 70.16958  ? 80  LYS F O   1 
ATOM   426  C CB  . LYS A 1 84  ? 166.56900 318.61600 -23.64200 1.000 65.55025  ? 80  LYS F CB  1 
ATOM   427  C CG  . LYS A 1 84  ? 166.42200 317.31800 -24.39100 1.000 71.51686  ? 80  LYS F CG  1 
ATOM   428  C CD  . LYS A 1 84  ? 166.56400 317.59600 -25.89000 1.000 79.47062  ? 80  LYS F CD  1 
ATOM   429  C CE  . LYS A 1 84  ? 167.29100 316.46900 -26.62300 1.000 91.46495  ? 80  LYS F CE  1 
ATOM   430  N NZ  . LYS A 1 84  ? 167.12900 316.58800 -28.10100 1.000 100.33500 ? 80  LYS F NZ  1 
ATOM   431  N N   . GLN A 1 85  ? 165.73600 320.91700 -21.53000 1.000 68.74613  ? 81  GLN F N   1 
ATOM   432  C CA  . GLN A 1 85  ? 166.00300 322.22000 -20.92400 1.000 70.62427  ? 81  GLN F CA  1 
ATOM   433  C C   . GLN A 1 85  ? 166.27200 322.08200 -19.43200 1.000 67.46389  ? 81  GLN F C   1 
ATOM   434  O O   . GLN A 1 85  ? 167.27300 322.59300 -18.90600 1.000 67.61402  ? 81  GLN F O   1 
ATOM   435  C CB  . GLN A 1 85  ? 164.80200 323.13100 -21.17700 1.000 68.68172  ? 81  GLN F CB  1 
ATOM   436  C CG  . GLN A 1 85  ? 164.73200 323.69300 -22.58200 1.000 79.35302  ? 81  GLN F CG  1 
ATOM   437  C CD  . GLN A 1 85  ? 163.61400 324.71400 -22.76800 1.000 85.88798  ? 81  GLN F CD  1 
ATOM   438  O OE1 . GLN A 1 85  ? 162.99000 325.17300 -21.80300 1.000 83.20235  ? 81  GLN F OE1 1 
ATOM   439  N NE2 . GLN A 1 85  ? 163.35100 325.06600 -24.02400 1.000 86.20545  ? 81  GLN F NE2 1 
ATOM   440  N N   . GLU A 1 86  ? 165.39900 321.36600 -18.73400 1.000 66.78043  ? 82  GLU F N   1 
ATOM   441  C CA  . GLU A 1 86  ? 165.63800 321.16700 -17.31700 1.000 68.16089  ? 82  GLU F CA  1 
ATOM   442  C C   . GLU A 1 86  ? 166.91100 320.34900 -17.08400 1.000 68.30139  ? 82  GLU F C   1 
ATOM   443  O O   . GLU A 1 86  ? 167.62900 320.57600 -16.10000 1.000 68.35311  ? 82  GLU F O   1 
ATOM   444  C CB  . GLU A 1 86  ? 164.42200 320.48000 -16.69300 1.000 64.65931  ? 82  GLU F CB  1 
ATOM   445  C CG  . GLU A 1 86  ? 164.47400 320.40700 -15.18700 1.000 68.21923  ? 82  GLU F CG  1 
ATOM   446  C CD  . GLU A 1 86  ? 164.34700 321.81500 -14.58800 1.000 68.79192  ? 82  GLU F CD  1 
ATOM   447  O OE1 . GLU A 1 86  ? 163.80700 322.70100 -15.29600 1.000 73.83177  ? 82  GLU F OE1 1 
ATOM   448  O OE2 . GLU A 1 86  ? 164.82500 322.05500 -13.45700 1.000 66.34616  ? 82  GLU F OE2 1 
ATOM   449  N N   . LEU A 1 87  ? 167.25800 319.45000 -18.00700 1.000 65.54469  ? 83  LEU F N   1 
ATOM   450  C CA  . LEU A 1 87  ? 168.49100 318.69600 -17.83400 1.000 66.75250  ? 83  LEU F CA  1 
ATOM   451  C C   . LEU A 1 87  ? 169.70000 319.58800 -18.00400 1.000 72.33027  ? 83  LEU F C   1 
ATOM   452  O O   . LEU A 1 87  ? 170.72800 319.35400 -17.36000 1.000 70.65461  ? 83  LEU F O   1 
ATOM   453  C CB  . LEU A 1 87  ? 168.57600 317.52600 -18.80400 1.000 69.55683  ? 83  LEU F CB  1 
ATOM   454  C CG  . LEU A 1 87  ? 167.74600 316.31500 -18.39800 1.000 73.96204  ? 83  LEU F CG  1 
ATOM   455  C CD1 . LEU A 1 87  ? 167.68400 315.30600 -19.53100 1.000 73.74582  ? 83  LEU F CD1 1 
ATOM   456  C CD2 . LEU A 1 87  ? 168.32900 315.68000 -17.14300 1.000 71.67564  ? 83  LEU F CD2 1 
ATOM   457  N N   . ASP A 1 88  ? 169.61400 320.60400 -18.86800 1.000 71.37312  ? 84  ASP F N   1 
ATOM   458  C CA  . ASP A 1 88  ? 170.75600 321.50400 -18.95600 1.000 72.27336  ? 84  ASP F CA  1 
ATOM   459  C C   . ASP A 1 88  ? 170.88100 322.34200 -17.70600 1.000 71.02832  ? 84  ASP F C   1 
ATOM   460  O O   . ASP A 1 88  ? 171.99700 322.60400 -17.25300 1.000 69.76560  ? 84  ASP F O   1 
ATOM   461  C CB  . ASP A 1 88  ? 170.65900 322.46300 -20.14000 1.000 72.48165  ? 84  ASP F CB  1 
ATOM   462  C CG  . ASP A 1 88  ? 170.86000 321.78500 -21.46000 1.000 85.41946  ? 84  ASP F CG  1 
ATOM   463  O OD1 . ASP A 1 88  ? 171.45200 320.68300 -21.49500 1.000 93.11845  ? 84  ASP F OD1 1 
ATOM   464  O OD2 . ASP A 1 88  ? 170.48500 322.39300 -22.47800 1.000 88.62301  ? 84  ASP F OD2 1 
ATOM   465  N N   . LYS A 1 89  ? 169.75900 322.73100 -17.10300 1.000 69.39051  ? 85  LYS F N   1 
ATOM   466  C CA  . LYS A 1 89  ? 169.90700 323.44200 -15.84300 1.000 63.47928  ? 85  LYS F CA  1 
ATOM   467  C C   . LYS A 1 89  ? 170.51700 322.55900 -14.75800 1.000 68.07239  ? 85  LYS F C   1 
ATOM   468  O O   . LYS A 1 89  ? 171.36700 323.03500 -13.98700 1.000 65.72829  ? 85  LYS F O   1 
ATOM   469  C CB  . LYS A 1 89  ? 168.55900 323.99400 -15.37700 1.000 67.75637  ? 85  LYS F CB  1 
ATOM   470  C CG  . LYS A 1 89  ? 168.08400 325.24300 -16.13600 1.000 71.13914  ? 85  LYS F CG  1 
ATOM   471  C CD  . LYS A 1 89  ? 166.56900 325.29500 -16.31800 1.000 70.13011  ? 85  LYS F CD  1 
ATOM   472  C CE  . LYS A 1 89  ? 165.88200 325.46800 -14.96700 1.000 72.17786  ? 85  LYS F CE  1 
ATOM   473  N NZ  . LYS A 1 89  ? 164.39300 325.48000 -15.06600 1.000 79.17415  ? 85  LYS F NZ  1 
ATOM   474  N N   . TYR A 1 90  ? 170.24400 321.24600 -14.79800 1.000 65.54463  ? 86  TYR F N   1 
ATOM   475  C CA  . TYR A 1 90  ? 170.92700 320.31800 -13.89400 1.000 61.49440  ? 86  TYR F CA  1 
ATOM   476  C C   . TYR A 1 90  ? 172.41900 320.16800 -14.19700 1.000 66.43654  ? 86  TYR F C   1 
ATOM   477  O O   . TYR A 1 90  ? 173.24900 320.13200 -13.27000 1.000 63.88469  ? 86  TYR F O   1 
ATOM   478  C CB  . TYR A 1 90  ? 170.25300 318.95900 -13.99000 1.000 61.20014  ? 86  TYR F CB  1 
ATOM   479  C CG  . TYR A 1 90  ? 171.00000 317.83700 -13.32000 1.000 59.35046  ? 86  TYR F CG  1 
ATOM   480  C CD1 . TYR A 1 90  ? 170.85100 317.58300 -11.96300 1.000 58.61970  ? 86  TYR F CD1 1 
ATOM   481  C CD2 . TYR A 1 90  ? 171.89500 317.05700 -14.04200 1.000 57.98655  ? 86  TYR F CD2 1 
ATOM   482  C CE1 . TYR A 1 90  ? 171.53700 316.55600 -11.35200 1.000 58.53040  ? 86  TYR F CE1 1 
ATOM   483  C CE2 . TYR A 1 90  ? 172.59000 316.04100 -13.44100 1.000 59.92090  ? 86  TYR F CE2 1 
ATOM   484  C CZ  . TYR A 1 90  ? 172.41400 315.79100 -12.09900 1.000 58.63185  ? 86  TYR F CZ  1 
ATOM   485  O OH  . TYR A 1 90  ? 173.11500 314.76300 -11.51400 1.000 63.15780  ? 86  TYR F OH  1 
ATOM   486  N N   . LYS A 1 91  ? 172.79700 320.14700 -15.47900 1.000 65.05271  ? 87  LYS F N   1 
ATOM   487  C CA  . LYS A 1 91  ? 174.21000 319.95200 -15.79300 1.000 66.88554  ? 87  LYS F CA  1 
ATOM   488  C C   . LYS A 1 91  ? 175.01100 321.19400 -15.43100 1.000 70.24000  ? 87  LYS F C   1 
ATOM   489  O O   . LYS A 1 91  ? 176.13400 321.09300 -14.92300 1.000 69.94375  ? 87  LYS F O   1 
ATOM   490  C CB  . LYS A 1 91  ? 174.42900 319.61100 -17.26800 1.000 71.44519  ? 87  LYS F CB  1 
ATOM   491  C CG  . LYS A 1 91  ? 173.87500 318.28900 -17.75800 1.000 77.64717  ? 87  LYS F CG  1 
ATOM   492  C CD  . LYS A 1 91  ? 172.84300 318.51400 -18.85400 1.000 81.93893  ? 87  LYS F CD  1 
ATOM   493  C CE  . LYS A 1 91  ? 173.36400 318.10000 -20.22300 1.000 94.19198  ? 87  LYS F CE  1 
ATOM   494  N NZ  . LYS A 1 91  ? 172.32400 318.25500 -21.28300 1.000 93.84495  ? 87  LYS F NZ  1 
ATOM   495  N N   . ASN A 1 92  ? 174.45500 322.37800 -15.70800 1.000 70.18534  ? 88  ASN F N   1 
ATOM   496  C CA  A ASN A 1 92  ? 175.12000 323.61300 -15.31200 0.890 69.25169  ? 88  ASN F CA  1 
ATOM   497  C CA  B ASN A 1 92  ? 175.13800 323.60000 -15.31800 0.110 68.87021  ? 88  ASN F CA  1 
ATOM   498  C C   . ASN A 1 92  ? 175.23500 323.70300 -13.80400 1.000 70.09565  ? 88  ASN F C   1 
ATOM   499  O O   . ASN A 1 92  ? 176.24100 324.18500 -13.28200 1.000 71.90128  ? 88  ASN F O   1 
ATOM   500  C CB  A ASN A 1 92  ? 174.36800 324.83100 -15.84300 0.890 69.99040  ? 88  ASN F CB  1 
ATOM   501  C CB  B ASN A 1 92  ? 174.45000 324.82900 -15.92700 0.110 70.12503  ? 88  ASN F CB  1 
ATOM   502  C CG  A ASN A 1 92  ? 174.42000 324.93600 -17.33700 0.890 69.95260  ? 88  ASN F CG  1 
ATOM   503  C CG  B ASN A 1 92  ? 173.11700 325.17500 -15.26600 0.110 69.84805  ? 88  ASN F CG  1 
ATOM   504  O OD1 A ASN A 1 92  ? 175.13100 324.18300 -17.99900 0.890 70.30703  ? 88  ASN F OD1 1 
ATOM   505  O OD1 B ASN A 1 92  ? 172.95200 325.07300 -14.05000 0.110 69.57408  ? 88  ASN F OD1 1 
ATOM   506  N ND2 A ASN A 1 92  ? 173.67500 325.89200 -17.88400 0.890 74.11754  ? 88  ASN F ND2 1 
ATOM   507  N ND2 B ASN A 1 92  ? 172.16700 325.62900 -16.07700 0.110 69.24110  ? 88  ASN F ND2 1 
ATOM   508  N N   . ALA A 1 93  ? 174.20800 323.24500 -13.07900 1.000 66.94886  ? 89  ALA F N   1 
ATOM   509  C CA  . ALA A 1 93  ? 174.31600 323.31000 -11.63100 1.000 66.93895  ? 89  ALA F CA  1 
ATOM   510  C C   . ALA A 1 93  ? 175.46300 322.44700 -11.13500 1.000 69.15480  ? 89  ALA F C   1 
ATOM   511  O O   . ALA A 1 93  ? 176.26300 322.88600 -10.29300 1.000 71.49033  ? 89  ALA F O   1 
ATOM   512  C CB  . ALA A 1 93  ? 173.00800 322.86800 -10.97900 1.000 60.58548  ? 89  ALA F CB  1 
ATOM   513  N N   . VAL A 1 94  ? 175.65600 321.28400 -11.75500 1.000 67.77714  ? 90  VAL F N   1 
ATOM   514  C CA  . VAL A 1 94  ? 176.76700 320.43100 -11.33800 1.000 69.61006  ? 90  VAL F CA  1 
ATOM   515  C C   . VAL A 1 94  ? 178.11900 321.02100 -11.73200 1.000 68.74036  ? 90  VAL F C   1 
ATOM   516  O O   . VAL A 1 94  ? 179.05500 321.04400 -10.92000 1.000 68.24122  ? 90  VAL F O   1 
ATOM   517  C CB  . VAL A 1 94  ? 176.59000 319.01000 -11.90700 1.000 67.11580  ? 90  VAL F CB  1 
ATOM   518  C CG1 . VAL A 1 94  ? 177.81500 318.13100 -11.59700 1.000 60.91014  ? 90  VAL F CG1 1 
ATOM   519  C CG2 . VAL A 1 94  ? 175.37300 318.38200 -11.29500 1.000 62.67853  ? 90  VAL F CG2 1 
ATOM   520  N N   . THR A 1 95  ? 178.23600 321.56600 -12.94300 1.000 66.42548  ? 91  THR F N   1 
ATOM   521  C CA  . THR A 1 95  ? 179.53300 322.12000 -13.32000 1.000 70.02037  ? 91  THR F CA  1 
ATOM   522  C C   . THR A 1 95  ? 179.85300 323.39000 -12.53700 1.000 74.03829  ? 91  THR F C   1 
ATOM   523  O O   . THR A 1 95  ? 181.02300 323.65800 -12.23700 1.000 75.01701  ? 91  THR F O   1 
ATOM   524  C CB  . THR A 1 95  ? 179.55900 322.41700 -14.81100 1.000 69.89466  ? 91  THR F CB  1 
ATOM   525  O OG1 . THR A 1 95  ? 178.55600 323.39400 -15.10600 1.000 76.66529  ? 91  THR F OG1 1 
ATOM   526  C CG2 . THR A 1 95  ? 179.24800 321.15800 -15.60500 1.000 74.00441  ? 91  THR F CG2 1 
ATOM   527  N N   . ASP A 1 96  ? 178.82700 324.16600 -12.17900 1.000 74.15945  ? 92  ASP F N   1 
ATOM   528  C CA  . ASP A 1 96  ? 179.02100 325.35600 -11.36600 1.000 73.51093  ? 92  ASP F CA  1 
ATOM   529  C C   . ASP A 1 96  ? 179.48500 324.98500 -9.96600  1.000 74.94069  ? 92  ASP F C   1 
ATOM   530  O O   . ASP A 1 96  ? 180.39800 325.61800 -9.42000  1.000 76.52075  ? 92  ASP F O   1 
ATOM   531  C CB  . ASP A 1 96  ? 177.71600 326.14100 -11.28500 1.000 72.85741  ? 92  ASP F CB  1 
ATOM   532  C CG  . ASP A 1 96  ? 177.41500 326.89400 -12.56000 1.000 73.23659  ? 92  ASP F CG  1 
ATOM   533  O OD1 . ASP A 1 96  ? 178.35400 327.26800 -13.28100 1.000 76.10244  ? 92  ASP F OD1 1 
ATOM   534  O OD2 . ASP A 1 96  ? 176.22600 327.14000 -12.83200 1.000 79.93348  ? 92  ASP F OD2 1 
ATOM   535  N N   . LEU A 1 97  ? 178.91700 323.91500 -9.39500  1.000 71.96934  ? 93  LEU F N   1 
ATOM   536  C CA  . LEU A 1 97  ? 179.38500 323.47700 -8.08700  1.000 68.71438  ? 93  LEU F CA  1 
ATOM   537  C C   . LEU A 1 97  ? 180.79100 322.92500 -8.17700  1.000 72.15757  ? 93  LEU F C   1 
ATOM   538  O O   . LEU A 1 97  ? 181.58800 323.09300 -7.24500  1.000 73.65155  ? 93  LEU F O   1 
ATOM   539  C CB  . LEU A 1 97  ? 178.45600 322.40300 -7.54900  1.000 69.13919  ? 93  LEU F CB  1 
ATOM   540  C CG  . LEU A 1 97  ? 177.06800 322.81000 -7.06200  1.000 72.64423  ? 93  LEU F CG  1 
ATOM   541  C CD1 . LEU A 1 97  ? 176.29000 321.56500 -6.62200  1.000 69.69433  ? 93  LEU F CD1 1 
ATOM   542  C CD2 . LEU A 1 97  ? 177.16500 323.85700 -5.93400  1.000 67.30490  ? 93  LEU F CD2 1 
ATOM   543  N N   . GLN A 1 98  ? 181.16600 322.44000 -9.35300  1.000 71.24529  ? 94  GLN F N   1 
ATOM   544  C CA  . GLN A 1 98  ? 182.50500 321.89900 -9.51200  1.000 73.01272  ? 94  GLN F CA  1 
ATOM   545  C C   . GLN A 1 98  ? 183.53000 323.02300 -9.60800  1.000 74.26827  ? 94  GLN F C   1 
ATOM   546  O O   . GLN A 1 98  ? 184.60100 322.93700 -8.99400  1.000 75.40798  ? 94  GLN F O   1 
ATOM   547  C CB  . GLN A 1 98  ? 182.55700 320.96500 -10.72600 1.000 66.62632  ? 94  GLN F CB  1 
ATOM   548  C CG  . GLN A 1 98  ? 181.89100 319.59600 -10.49900 1.000 68.98897  ? 94  GLN F CG  1 
ATOM   549  C CD  . GLN A 1 98  ? 181.89100 318.70900 -11.74600 1.000 74.29697  ? 94  GLN F CD  1 
ATOM   550  O OE1 . GLN A 1 98  ? 181.95200 319.20100 -12.87000 1.000 76.91050  ? 94  GLN F OE1 1 
ATOM   551  N NE2 . GLN A 1 98  ? 181.89900 317.39500 -11.54300 1.000 72.17401  ? 94  GLN F NE2 1 
ATOM   552  N N   . LEU A 1 99  ? 183.24200 324.07200 -10.38500 1.000 74.54121  ? 95  LEU F N   1 
ATOM   553  C CA  . LEU A 1 99  ? 184.19100 325.18000 -10.42000 1.000 76.95216  ? 95  LEU F CA  1 
ATOM   554  C C   . LEU A 1 99  ? 184.18300 325.99500 -9.12300  1.000 77.26271  ? 95  LEU F C   1 
ATOM   555  O O   . LEU A 1 99  ? 185.19900 326.61600 -8.79800  1.000 82.01312  ? 95  LEU F O   1 
ATOM   556  C CB  . LEU A 1 99  ? 183.86800 326.06800 -11.63200 1.000 68.55938  ? 95  LEU F CB  1 
ATOM   557  C CG  . LEU A 1 99  ? 184.64500 327.35600 -11.93300 1.000 71.27144  ? 95  LEU F CG  1 
ATOM   558  C CD1 . LEU A 1 99  ? 185.97400 327.07300 -12.63900 1.000 68.07939  ? 95  LEU F CD1 1 
ATOM   559  C CD2 . LEU A 1 99  ? 183.78800 328.30500 -12.77000 1.000 62.17299  ? 95  LEU F CD2 1 
ATOM   560  N N   . LEU A 1 100 ? 183.11100 325.90500 -8.32000  1.000 77.17860  ? 96  LEU F N   1 
ATOM   561  C CA  . LEU A 1 100 ? 183.07200 326.52800 -6.99500  1.000 80.63816  ? 96  LEU F CA  1 
ATOM   562  C C   . LEU A 1 100 ? 183.94200 325.76800 -6.01700  1.000 81.99546  ? 96  LEU F C   1 
ATOM   563  O O   . LEU A 1 100 ? 184.52600 326.35300 -5.09900  1.000 84.90309  ? 96  LEU F O   1 
ATOM   564  C CB  . LEU A 1 100 ? 181.64000 326.58500 -6.43000  1.000 79.53043  ? 96  LEU F CB  1 
ATOM   565  C CG  . LEU A 1 100 ? 181.38000 327.18400 -5.01400  1.000 77.44996  ? 96  LEU F CG  1 
ATOM   566  C CD1 . LEU A 1 100 ? 181.71100 328.68100 -4.89700  1.000 72.93211  ? 96  LEU F CD1 1 
ATOM   567  C CD2 . LEU A 1 100 ? 179.96800 326.92200 -4.47500  1.000 73.35971  ? 96  LEU F CD2 1 
ATOM   568  N N   . MET A 1 101 ? 184.06200 324.46300 -6.24200  1.000 82.57810  ? 97  MET F N   1 
ATOM   569  C CA  . MET A 1 101 ? 184.80400 323.54600 -5.38400  1.000 81.71109  ? 97  MET F CA  1 
ATOM   570  C C   . MET A 1 101 ? 186.27400 323.41800 -5.72600  1.000 81.91864  ? 97  MET F C   1 
ATOM   571  O O   . MET A 1 101 ? 187.06600 323.04200 -4.85900  1.000 85.76940  ? 97  MET F O   1 
ATOM   572  C CB  . MET A 1 101 ? 184.24000 322.14200 -5.62100  1.000 80.13293  ? 97  MET F CB  1 
ATOM   573  C CG  . MET A 1 101 ? 182.98200 321.76100 -4.91400  1.000 82.91547  ? 97  MET F CG  1 
ATOM   574  S SD  . MET A 1 101 ? 183.09400 321.84700 -3.15300  1.000 98.20372  ? 97  MET F SD  1 
ATOM   575  C CE  . MET A 1 101 ? 183.18800 323.61600 -2.88500  1.000 80.99612  ? 97  MET F CE  1 
ATOM   576  N N   . GLN A 1 102 ? 186.65200 323.79000 -6.94300  1.000 83.29384  ? 98  GLN F N   1 
ATOM   577  C CA  . GLN A 1 102 ? 188.05700 323.85100 -7.34200  1.000 85.46950  ? 98  GLN F CA  1 
ATOM   578  C C   . GLN A 1 102 ? 188.85800 324.86100 -6.52300  1.000 91.69803  ? 98  GLN F C   1 
ATOM   579  O O   . GLN A 1 102 ? 189.99200 324.57700 -6.11500  1.000 92.39890  ? 98  GLN F O   1 
ATOM   580  C CB  . GLN A 1 102 ? 188.10500 324.14500 -8.83600  1.000 82.93948  ? 98  GLN F CB  1 
ATOM   581  C CG  . GLN A 1 102 ? 187.91000 322.87000 -9.64600  1.000 83.79412  ? 98  GLN F CG  1 
ATOM   582  C CD  . GLN A 1 102 ? 188.24800 323.02300 -11.10400 1.000 91.12036  ? 98  GLN F CD  1 
ATOM   583  O OE1 . GLN A 1 102 ? 189.27000 323.61200 -11.47100 1.000 95.86655  ? 98  GLN F OE1 1 
ATOM   584  N NE2 . GLN A 1 102 ? 187.36700 322.50700 -11.96100 1.000 95.24544  ? 98  GLN F NE2 1 
ATOM   585  N N   . SER A 1 103 ? 188.28100 326.02600 -6.24800  1.000 88.18630  ? 99  SER F N   1 
ATOM   586  C CA  . SER A 1 103 ? 188.92800 327.06300 -5.44900  1.000 91.89279  ? 99  SER F CA  1 
ATOM   587  C C   . SER A 1 103 ? 187.90700 327.63000 -4.47300  1.000 92.71646  ? 99  SER F C   1 
ATOM   588  O O   . SER A 1 103 ? 186.98800 328.34900 -4.87500  1.000 93.24119  ? 99  SER F O   1 
ATOM   589  C CB  . SER A 1 103 ? 189.52100 328.16200 -6.33500  1.000 95.76818  ? 99  SER F CB  1 
ATOM   590  O OG  . SER A 1 103 ? 188.51400 328.86800 -7.04400  1.000 92.14787  ? 99  SER F OG  1 
ATOM   591  N N   . THR A 1 104 ? 188.08600 327.32200 -3.18700  1.000 94.85284  ? 100 THR F N   1 
ATOM   592  C CA  . THR A 1 104 ? 187.15700 327.74500 -2.14400  1.000 103.30486 ? 100 THR F CA  1 
ATOM   593  C C   . THR A 1 104 ? 187.80300 328.85500 -1.31500  1.000 104.43375 ? 100 THR F C   1 
ATOM   594  O O   . THR A 1 104 ? 188.88000 328.67500 -0.72000  1.000 104.81578 ? 100 THR F O   1 
ATOM   595  C CB  . THR A 1 104 ? 186.76100 326.54100 -1.27200  1.000 108.57578 ? 100 THR F CB  1 
ATOM   596  O OG1 . THR A 1 104 ? 185.47000 326.76400 -0.69300  1.000 109.47021 ? 100 THR F OG1 1 
ATOM   597  C CG2 . THR A 1 104 ? 187.79000 326.26500 -0.15700  1.000 108.39061 ? 100 THR F CG2 1 
ATOM   598  N N   . PRO A 1 105 ? 187.18000 330.04300 -1.33200  1.000 104.01683 ? 101 PRO F N   1 
ATOM   599  C CA  . PRO A 1 105 ? 187.72000 331.21200 -0.61000  1.000 101.05612 ? 101 PRO F CA  1 
ATOM   600  C C   . PRO A 1 105 ? 187.74200 331.17200 0.91700   1.000 105.13866 ? 101 PRO F C   1 
ATOM   601  O O   . PRO A 1 105 ? 186.81300 330.69100 1.57400   1.000 107.11974 ? 101 PRO F O   1 
ATOM   602  C CB  . PRO A 1 105 ? 186.77500 332.34900 -1.04400  1.000 98.97149  ? 101 PRO F CB  1 
ATOM   603  C CG  . PRO A 1 105 ? 186.06800 331.86900 -2.28200  1.000 94.61091  ? 101 PRO F CG  1 
ATOM   604  C CD  . PRO A 1 105 ? 185.95800 330.37100 -2.09700  1.000 98.01504  ? 101 PRO F CD  1 
ATOM   605  N N   . ALA A 1 106 ? 188.84000 331.70000 1.46400   1.000 100.31944 ? 102 ALA F N   1 
ATOM   606  C CA  . ALA A 1 106 ? 189.04600 331.86700 2.89700   1.000 99.90102  ? 102 ALA F CA  1 
ATOM   607  C C   . ALA A 1 106 ? 188.08900 332.95000 3.41100   1.000 106.96224 ? 102 ALA F C   1 
ATOM   608  O O   . ALA A 1 106 ? 187.77400 333.90700 2.69400   1.000 106.53249 ? 102 ALA F O   1 
ATOM   609  C CB  . ALA A 1 106 ? 190.50000 332.24000 3.19700   1.000 85.61934  ? 102 ALA F CB  1 
ATOM   610  N N   . THR A 1 107 ? 187.62200 332.81600 4.65800   1.000 109.30324 ? 103 THR F N   1 
ATOM   611  C CA  . THR A 1 107 ? 186.69700 333.83200 5.16900   1.000 108.46258 ? 103 THR F CA  1 
ATOM   612  C C   . THR A 1 107 ? 187.30300 334.51800 6.39200   1.000 109.51780 ? 103 THR F C   1 
ATOM   613  O O   . THR A 1 107 ? 186.73200 334.47200 7.49000   1.000 109.31869 ? 103 THR F O   1 
ATOM   614  C CB  . THR A 1 107 ? 185.31800 333.24700 5.53800   1.000 109.54397 ? 103 THR F CB  1 
ATOM   615  O OG1 . THR A 1 107 ? 185.45400 332.24600 6.55600   1.000 105.65146 ? 103 THR F OG1 1 
ATOM   616  C CG2 . THR A 1 107 ? 184.62600 332.63300 4.30900   1.000 102.36165 ? 103 THR F CG2 1 
ATOM   617  N N   . GLY A 1 108 ? 188.46100 335.16200 6.19800   1.000 103.08913 ? 143 GLY F N   1 
ATOM   618  C CA  . GLY A 1 108 ? 189.11400 335.93800 7.23600   1.000 102.01851 ? 143 GLY F CA  1 
ATOM   619  C C   . GLY A 1 108 ? 189.65900 335.10900 8.38400   1.000 100.08866 ? 143 GLY F C   1 
ATOM   620  O O   . GLY A 1 108 ? 189.28700 335.32200 9.54500   1.000 101.23044 ? 143 GLY F O   1 
ATOM   621  N N   . SER A 1 109 ? 190.55000 334.16700 8.07400   1.000 95.11465  ? 144 SER F N   1 
ATOM   622  C CA  . SER A 1 109 ? 191.20400 333.28400 9.05100   1.000 96.27376  ? 144 SER F CA  1 
ATOM   623  C C   . SER A 1 109 ? 190.27500 332.15000 9.46100   1.000 90.93973  ? 144 SER F C   1 
ATOM   624  O O   . SER A 1 109 ? 190.64100 331.34700 10.34000  1.000 87.38446  ? 144 SER F O   1 
ATOM   625  C CB  . SER A 1 109 ? 191.66200 334.03800 10.31000  1.000 83.76236  ? 144 SER F CB  1 
ATOM   626  O OG  . SER A 1 109 ? 192.99700 334.53400 10.17700  1.000 76.31013  ? 144 SER F OG  1 
ATOM   627  N N   . GLY A 1 110 ? 189.10300 332.03800 8.83200   1.000 91.65943  ? 145 GLY F N   1 
ATOM   628  C CA  . GLY A 1 110 ? 188.12100 331.03600 9.18200   1.000 83.47361  ? 145 GLY F CA  1 
ATOM   629  C C   . GLY A 1 110 ? 187.80800 331.04100 10.66400  1.000 80.55637  ? 145 GLY F C   1 
ATOM   630  O O   . GLY A 1 110 ? 187.21500 331.98900 11.19700  1.000 86.54020  ? 145 GLY F O   1 
ATOM   631  N N   . SER A 1 111 ? 188.24100 329.98700 11.34200  1.000 65.08634  ? 146 SER F N   1 
ATOM   632  C CA  . SER A 1 111 ? 188.07000 329.82400 12.77900  1.000 63.02926  ? 146 SER F CA  1 
ATOM   633  C C   . SER A 1 111 ? 186.60700 329.58200 13.12300  1.000 58.38803  ? 146 SER F C   1 
ATOM   634  O O   . SER A 1 111 ? 186.29700 328.52900 13.68500  1.000 61.77256  ? 146 SER F O   1 
ATOM   635  C CB  . SER A 1 111 ? 188.62500 330.99600 13.58200  1.000 63.81965  ? 146 SER F CB  1 
ATOM   636  O OG  . SER A 1 111 ? 188.72500 330.60400 14.96100  1.000 57.76239  ? 146 SER F OG  1 
ATOM   637  N N   . ALA A 1 112 ? 185.68700 330.50000 12.81800  1.000 56.98309  ? 147 ALA F N   1 
ATOM   638  C CA  . ALA A 1 112 ? 184.36700 330.05700 13.24500  1.000 56.86215  ? 147 ALA F CA  1 
ATOM   639  C C   . ALA A 1 112 ? 183.83900 328.88800 12.40900  1.000 61.51113  ? 147 ALA F C   1 
ATOM   640  O O   . ALA A 1 112 ? 182.87000 328.26800 12.83800  1.000 62.69666  ? 147 ALA F O   1 
ATOM   641  C CB  . ALA A 1 112 ? 183.36200 331.20500 13.15900  1.000 50.61130  ? 147 ALA F CB  1 
ATOM   642  N N   . ILE A 1 113 ? 184.53800 328.45400 11.35900  1.000 56.92706  ? 148 ILE F N   1 
ATOM   643  C CA  . ILE A 1 113 ? 184.08400 327.35400 10.51500  1.000 61.96692  ? 148 ILE F CA  1 
ATOM   644  C C   . ILE A 1 113 ? 185.05400 326.18900 10.53900  1.000 60.16905  ? 148 ILE F C   1 
ATOM   645  O O   . ILE A 1 113 ? 184.83000 325.20300 9.84200   1.000 62.92834  ? 148 ILE F O   1 
ATOM   646  C CB  . ILE A 1 113 ? 183.80100 327.77200 9.05300   1.000 54.85397  ? 148 ILE F CB  1 
ATOM   647  C CG1 . ILE A 1 113 ? 185.04600 328.32100 8.36900   1.000 58.44466  ? 148 ILE F CG1 1 
ATOM   648  C CG2 . ILE A 1 113 ? 182.59600 328.69900 8.94300   1.000 55.03573  ? 148 ILE F CG2 1 
ATOM   649  C CD1 . ILE A 1 113 ? 184.77100 328.70200 6.94600   1.000 64.15622  ? 148 ILE F CD1 1 
ATOM   650  N N   . ALA A 1 114 ? 186.13700 326.28800 11.31300  1.000 61.40947  ? 149 ALA F N   1 
ATOM   651  C CA  . ALA A 1 114 ? 187.21900 325.31600 11.22600  1.000 59.33013  ? 149 ALA F CA  1 
ATOM   652  C C   . ALA A 1 114 ? 186.74100 323.89900 11.49800  1.000 59.91016  ? 149 ALA F C   1 
ATOM   653  O O   . ALA A 1 114 ? 187.30500 322.94400 10.95300  1.000 60.48617  ? 149 ALA F O   1 
ATOM   654  C CB  . ALA A 1 114 ? 188.33500 325.69000 12.20300  1.000 55.45889  ? 149 ALA F CB  1 
ATOM   655  N N   . SER A 1 115 ? 185.73100 323.72600 12.34700  1.000 56.41714  ? 150 SER F N   1 
ATOM   656  C CA  . SER A 1 115 ? 185.19000 322.38500 12.55500  1.000 63.77449  ? 150 SER F CA  1 
ATOM   657  C C   . SER A 1 115 ? 184.70400 321.79000 11.23300  1.000 67.08280  ? 150 SER F C   1 
ATOM   658  O O   . SER A 1 115 ? 185.15200 320.71100 10.79200  1.000 64.76908  ? 150 SER F O   1 
ATOM   659  C CB  . SER A 1 115 ? 184.04900 322.44500 13.56800  1.000 60.35290  ? 150 SER F CB  1 
ATOM   660  O OG  . SER A 1 115 ? 184.55600 322.37500 14.88400  1.000 69.62120  ? 150 SER F OG  1 
ATOM   661  N N   . GLY A 1 116 ? 183.78900 322.50200 10.57000  1.000 61.02739  ? 151 GLY F N   1 
ATOM   662  C CA  . GLY A 1 116 ? 183.26300 321.98200 9.32800   1.000 65.05611  ? 151 GLY F CA  1 
ATOM   663  C C   . GLY A 1 116 ? 184.32600 321.88900 8.25700   1.000 63.42698  ? 151 GLY F C   1 
ATOM   664  O O   . GLY A 1 116 ? 184.33400 320.94700 7.46500   1.000 67.90631  ? 151 GLY F O   1 
ATOM   665  N N   . VAL A 1 117 ? 185.26300 322.83900 8.23900   1.000 63.93248  ? 152 VAL F N   1 
ATOM   666  C CA  . VAL A 1 117 ? 186.33100 322.76900 7.24700   1.000 64.06752  ? 152 VAL F CA  1 
ATOM   667  C C   . VAL A 1 117 ? 187.18700 321.52800 7.46100   1.000 63.81907  ? 152 VAL F C   1 
ATOM   668  O O   . VAL A 1 117 ? 187.68000 320.92200 6.49800   1.000 68.14815  ? 152 VAL F O   1 
ATOM   669  C CB  . VAL A 1 117 ? 187.16800 324.06000 7.29300   1.000 61.36212  ? 152 VAL F CB  1 
ATOM   670  C CG1 . VAL A 1 117 ? 188.48300 323.89300 6.55300   1.000 57.60403  ? 152 VAL F CG1 1 
ATOM   671  C CG2 . VAL A 1 117 ? 186.37600 325.19300 6.70400   1.000 54.88988  ? 152 VAL F CG2 1 
ATOM   672  N N   . ALA A 1 118 ? 187.40800 321.14000 8.72600   1.000 65.60060  ? 153 ALA F N   1 
ATOM   673  C CA  . ALA A 1 118 ? 188.16500 319.91500 8.97200   1.000 65.12279  ? 153 ALA F CA  1 
ATOM   674  C C   . ALA A 1 118 ? 187.41300 318.69200 8.45800   1.000 68.64494  ? 153 ALA F C   1 
ATOM   675  O O   . ALA A 1 118 ? 188.02500 317.76200 7.90100   1.000 66.70352  ? 153 ALA F O   1 
ATOM   676  C CB  . ALA A 1 118 ? 188.45900 319.78100 10.46000  1.000 60.04328  ? 153 ALA F CB  1 
ATOM   677  N N   . VAL A 1 119 ? 186.07500 318.75200 8.48400   1.000 67.99137  ? 154 VAL F N   1 
ATOM   678  C CA  . VAL A 1 119 ? 185.32800 317.60000 7.97700   1.000 68.10734  ? 154 VAL F CA  1 
ATOM   679  C C   . VAL A 1 119 ? 185.37300 317.57600 6.45800   1.000 70.98524  ? 154 VAL F C   1 
ATOM   680  O O   . VAL A 1 119 ? 185.42900 316.50500 5.84400   1.000 75.84143  ? 154 VAL F O   1 
ATOM   681  C CB  . VAL A 1 119 ? 183.88700 317.56100 8.50000   1.000 68.66227  ? 154 VAL F CB  1 
ATOM   682  C CG1 . VAL A 1 119 ? 183.20500 316.30700 7.99200   1.000 72.51951  ? 154 VAL F CG1 1 
ATOM   683  C CG2 . VAL A 1 119 ? 183.91300 317.50400 10.02500  1.000 63.72985  ? 154 VAL F CG2 1 
ATOM   684  N N   . CYS A 1 120 ? 185.33000 318.74600 5.82200   1.000 70.53991  ? 155 CYS F N   1 
ATOM   685  C CA  . CYS A 1 120 ? 185.42000 318.73600 4.37200   1.000 71.68771  ? 155 CYS F CA  1 
ATOM   686  C C   . CYS A 1 120 ? 186.78800 318.23800 3.93600   1.000 71.66687  ? 155 CYS F C   1 
ATOM   687  O O   . CYS A 1 120 ? 186.88800 317.50800 2.94600   1.000 75.22446  ? 155 CYS F O   1 
ATOM   688  C CB  . CYS A 1 120 ? 185.19400 320.13100 3.79200   1.000 67.50360  ? 155 CYS F CB  1 
ATOM   689  S SG  . CYS A 1 120 ? 183.49000 320.79300 3.78600   1.000 87.44183  ? 155 CYS F SG  1 
ATOM   690  N N   . LYS A 1 121 ? 187.84000 318.55000 4.70300   1.000 67.78975  ? 156 LYS F N   1 
ATOM   691  C CA  . LYS A 1 121 ? 189.16300 318.06800 4.31700   1.000 69.60553  ? 156 LYS F CA  1 
ATOM   692  C C   . LYS A 1 121 ? 189.27800 316.55800 4.48100   1.000 74.13975  ? 156 LYS F C   1 
ATOM   693  O O   . LYS A 1 121 ? 189.95800 315.90300 3.68400   1.000 77.48792  ? 156 LYS F O   1 
ATOM   694  C CB  . LYS A 1 121 ? 190.22600 318.77200 5.16400   1.000 68.27012  ? 156 LYS F CB  1 
ATOM   695  C CG  . LYS A 1 121 ? 191.67200 318.51400 4.77100   1.000 77.22692  ? 156 LYS F CG  1 
ATOM   696  C CD  . LYS A 1 121 ? 192.01100 319.08200 3.39400   1.000 78.82926  ? 156 LYS F CD  1 
ATOM   697  C CE  . LYS A 1 121 ? 193.46500 319.57300 3.34800   1.000 79.27658  ? 156 LYS F CE  1 
ATOM   698  N NZ  . LYS A 1 121 ? 193.67600 320.62200 2.30100   1.000 79.43747  ? 156 LYS F NZ  1 
ATOM   699  N N   . VAL A 1 122 ? 188.55600 315.98500 5.44900   1.000 71.47244  ? 157 VAL F N   1 
ATOM   700  C CA  . VAL A 1 122 ? 188.56400 314.53000 5.62100   1.000 75.97346  ? 157 VAL F CA  1 
ATOM   701  C C   . VAL A 1 122 ? 187.80000 313.88400 4.47800   1.000 80.10049  ? 157 VAL F C   1 
ATOM   702  O O   . VAL A 1 122 ? 188.15400 312.80500 3.98300   1.000 81.74299  ? 157 VAL F O   1 
ATOM   703  C CB  . VAL A 1 122 ? 188.02400 314.07600 6.98900   1.000 72.56621  ? 157 VAL F CB  1 
ATOM   704  C CG1 . VAL A 1 122 ? 188.86800 314.63900 8.12300   1.000 74.92215  ? 157 VAL F CG1 1 
ATOM   705  C CG2 . VAL A 1 122 ? 186.56400 314.38400 7.14100   1.000 78.11834  ? 157 VAL F CG2 1 
ATOM   706  N N   . LEU A 1 123 ? 186.73500 314.54900 4.04800   1.000 78.02755  ? 158 LEU F N   1 
ATOM   707  C CA  . LEU A 1 123 ? 185.88500 314.03600 2.99200   1.000 78.92184  ? 158 LEU F CA  1 
ATOM   708  C C   . LEU A 1 123 ? 186.64800 313.93200 1.67200   1.000 77.23568  ? 158 LEU F C   1 
ATOM   709  O O   . LEU A 1 123 ? 186.35100 313.05200 0.86100   1.000 82.66532  ? 158 LEU F O   1 
ATOM   710  C CB  . LEU A 1 123 ? 184.69100 314.97900 2.88300   1.000 74.26599  ? 158 LEU F CB  1 
ATOM   711  C CG  . LEU A 1 123 ? 183.49600 314.59600 3.76200   1.000 73.13077  ? 158 LEU F CG  1 
ATOM   712  C CD1 . LEU A 1 123 ? 182.19400 315.27500 3.33700   1.000 77.49713  ? 158 LEU F CD1 1 
ATOM   713  C CD2 . LEU A 1 123 ? 183.33800 313.10100 3.86900   1.000 79.81401  ? 158 LEU F CD2 1 
ATOM   714  N N   . HIS A 1 124 ? 187.65400 314.77700 1.45500   1.000 73.98707  ? 159 HIS F N   1 
ATOM   715  C CA  . HIS A 1 124 ? 188.45200 314.71000 0.23400   1.000 78.50814  ? 159 HIS F CA  1 
ATOM   716  C C   . HIS A 1 124 ? 189.34800 313.47300 0.17400   1.000 85.64086  ? 159 HIS F C   1 
ATOM   717  O O   . HIS A 1 124 ? 189.96100 313.23000 -0.87100  1.000 89.25425  ? 159 HIS F O   1 
ATOM   718  C CB  . HIS A 1 124 ? 189.33500 315.94500 0.08300   1.000 75.95888  ? 159 HIS F CB  1 
ATOM   719  C CG  . HIS A 1 124 ? 188.64400 317.12300 -0.53200  1.000 81.45132  ? 159 HIS F CG  1 
ATOM   720  N ND1 . HIS A 1 124 ? 187.41300 317.57300 -0.10600  1.000 75.44330  ? 159 HIS F ND1 1 
ATOM   721  C CD2 . HIS A 1 124 ? 189.02300 317.95500 -1.53300  1.000 83.46080  ? 159 HIS F CD2 1 
ATOM   722  C CE1 . HIS A 1 124 ? 187.05900 318.62700 -0.82200  1.000 75.52027  ? 159 HIS F CE1 1 
ATOM   723  N NE2 . HIS A 1 124 ? 188.02100 318.88200 -1.69100  1.000 80.82488  ? 159 HIS F NE2 1 
ATOM   724  N N   . LEU A 1 125 ? 189.51300 312.73800 1.27300   1.000 85.70006  ? 160 LEU F N   1 
ATOM   725  C CA  . LEU A 1 125 ? 190.29100 311.50600 1.22300   1.000 87.22593  ? 160 LEU F CA  1 
ATOM   726  C C   . LEU A 1 125 ? 189.59200 310.42600 0.40300   1.000 90.13321  ? 160 LEU F C   1 
ATOM   727  O O   . LEU A 1 125 ? 188.36100 310.30200 0.40700   1.000 92.56250  ? 160 LEU F O   1 
ATOM   728  C CB  . LEU A 1 125 ? 190.54200 310.98000 2.63100   1.000 85.37997  ? 160 LEU F CB  1 
ATOM   729  C CG  . LEU A 1 125 ? 191.27900 311.93200 3.56700   1.000 86.75304  ? 160 LEU F CG  1 
ATOM   730  C CD1 . LEU A 1 125 ? 191.47400 311.26100 4.91600   1.000 85.34102  ? 160 LEU F CD1 1 
ATOM   731  C CD2 . LEU A 1 125 ? 192.61600 312.36100 2.96600   1.000 83.40074  ? 160 LEU F CD2 1 
ATOM   732  N N   . GLU A 1 126 ? 190.40800 309.56600 -0.20700  1.000 93.67029  ? 161 GLU F N   1 
ATOM   733  C CA  . GLU A 1 126 ? 189.90400 308.49000 -1.05200  1.000 91.68705  ? 161 GLU F CA  1 
ATOM   734  C C   . GLU A 1 126 ? 189.24800 307.43400 -0.18500  1.000 89.16769  ? 161 GLU F C   1 
ATOM   735  O O   . GLU A 1 126 ? 189.81800 306.98800 0.81400   1.000 88.93421  ? 161 GLU F O   1 
ATOM   736  C CB  . GLU A 1 126 ? 191.01600 307.87600 -1.89800  1.000 89.60029  ? 161 GLU F CB  1 
ATOM   737  C CG  . GLU A 1 126 ? 192.32700 307.70100 -1.17800  1.000 97.92091  ? 161 GLU F CG  1 
ATOM   738  C CD  . GLU A 1 126 ? 193.24300 308.90700 -1.34200  1.000 105.35194 ? 161 GLU F CD  1 
ATOM   739  O OE1 . GLU A 1 126 ? 193.16600 309.83800 -0.50400  1.000 102.44363 ? 161 GLU F OE1 1 
ATOM   740  O OE2 . GLU A 1 126 ? 194.05500 308.91200 -2.29700  1.000 109.46941 ? 161 GLU F OE2 1 
ATOM   741  N N   . GLY A 1 127 ? 188.02200 307.08200 -0.53200  1.000 89.68998  ? 162 GLY F N   1 
ATOM   742  C CA  . GLY A 1 127 ? 187.29600 306.09800 0.22200   1.000 86.81852  ? 162 GLY F CA  1 
ATOM   743  C C   . GLY A 1 127 ? 186.35100 306.69500 1.22900   1.000 87.29772  ? 162 GLY F C   1 
ATOM   744  O O   . GLY A 1 127 ? 185.51100 305.97100 1.77600   1.000 87.84801  ? 162 GLY F O   1 
ATOM   745  N N   . GLU A 1 128 ? 186.45800 307.99100 1.49200   1.000 87.54279  ? 163 GLU F N   1 
ATOM   746  C CA  . GLU A 1 128 ? 185.58900 308.55300 2.50700   1.000 87.30378  ? 163 GLU F CA  1 
ATOM   747  C C   . GLU A 1 128 ? 184.19300 308.82900 1.94600   1.000 84.50530  ? 163 GLU F C   1 
ATOM   748  O O   . GLU A 1 128 ? 183.17200 308.50400 2.58900   1.000 86.81639  ? 163 GLU F O   1 
ATOM   749  C CB  . GLU A 1 128 ? 186.23100 309.84300 3.01900   1.000 88.27577  ? 163 GLU F CB  1 
ATOM   750  C CG  . GLU A 1 128 ? 185.90800 310.27300 4.44500   1.000 88.07892  ? 163 GLU F CG  1 
ATOM   751  C CD  . GLU A 1 128 ? 186.42400 309.28600 5.48000   1.000 84.34908  ? 163 GLU F CD  1 
ATOM   752  O OE1 . GLU A 1 128 ? 187.48400 308.69500 5.22400   1.000 85.79228  ? 163 GLU F OE1 1 
ATOM   753  O OE2 . GLU A 1 128 ? 185.82900 309.18600 6.58000   1.000 80.48859  ? 163 GLU F OE2 1 
ATOM   754  N N   . VAL A 1 129 ? 184.11800 309.33100 0.70900   1.000 83.45867  ? 164 VAL F N   1 
ATOM   755  C CA  . VAL A 1 129 ? 182.79100 309.48600 0.14100   1.000 82.71844  ? 164 VAL F CA  1 
ATOM   756  C C   . VAL A 1 129 ? 182.13900 308.13000 -0.08300  1.000 87.66854  ? 164 VAL F C   1 
ATOM   757  O O   . VAL A 1 129 ? 180.92300 308.00500 0.06300   1.000 87.74132  ? 164 VAL F O   1 
ATOM   758  C CB  . VAL A 1 129 ? 182.86200 310.25900 -1.18700  1.000 83.33942  ? 164 VAL F CB  1 
ATOM   759  C CG1 . VAL A 1 129 ? 183.71800 311.51000 -1.04300  1.000 83.98203  ? 164 VAL F CG1 1 
ATOM   760  C CG2 . VAL A 1 129 ? 183.35100 309.35500 -2.30900  1.000 89.25637  ? 164 VAL F CG2 1 
ATOM   761  N N   . ASN A 1 130 ? 182.92700 307.07400 -0.34000  1.000 89.30865  ? 165 ASN F N   1 
ATOM   762  C CA  . ASN A 1 130 ? 182.33300 305.74200 -0.47700  1.000 86.51471  ? 165 ASN F CA  1 
ATOM   763  C C   . ASN A 1 130 ? 181.79400 305.24500 0.84800   1.000 86.62166  ? 165 ASN F C   1 
ATOM   764  O O   . ASN A 1 130 ? 180.79300 304.52100 0.88000   1.000 89.31564  ? 165 ASN F O   1 
ATOM   765  C CB  . ASN A 1 130 ? 183.30400 304.74600 -1.11300  1.000 86.35225  ? 165 ASN F CB  1 
ATOM   766  C CG  . ASN A 1 130 ? 183.82900 305.22800 -2.44600  1.000 90.03199  ? 165 ASN F CG  1 
ATOM   767  O OD1 . ASN A 1 130 ? 185.03800 305.26100 -2.68400  1.000 93.99907  ? 165 ASN F OD1 1 
ATOM   768  N ND2 . ASN A 1 130 ? 182.91000 305.58500 -3.34200  1.000 85.59470  ? 165 ASN F ND2 1 
ATOM   769  N N   . LYS A 1 131 ? 182.34900 305.73600 1.94800   1.000 85.65345  ? 166 LYS F N   1 
ATOM   770  C CA  . LYS A 1 131 ? 181.89000 305.28100 3.25000   1.000 88.13961  ? 166 LYS F CA  1 
ATOM   771  C C   . LYS A 1 131 ? 180.50800 305.86300 3.49900   1.000 90.42421  ? 166 LYS F C   1 
ATOM   772  O O   . LYS A 1 131 ? 179.56300 305.13900 3.86000   1.000 88.72746  ? 166 LYS F O   1 
ATOM   773  C CB  . LYS A 1 131 ? 182.88300 305.72400 4.33100   1.000 85.73149  ? 166 LYS F CB  1 
ATOM   774  C CG  . LYS A 1 131 ? 182.52200 305.31500 5.74800   1.000 89.36144  ? 166 LYS F CG  1 
ATOM   775  C CD  . LYS A 1 131 ? 183.51000 305.86300 6.80000   1.000 88.33372  ? 166 LYS F CD  1 
ATOM   776  C CE  . LYS A 1 131 ? 184.95000 305.40300 6.59700   1.000 88.84838  ? 166 LYS F CE  1 
ATOM   777  N NZ  . LYS A 1 131 ? 185.84100 305.98100 7.64900   1.000 87.93741  ? 166 LYS F NZ  1 
ATOM   778  N N   . ILE A 1 132 ? 180.37700 307.18400 3.35200   1.000 90.39342  ? 167 ILE F N   1 
ATOM   779  C CA  . ILE A 1 132 ? 179.03100 307.74700 3.50900   1.000 92.25422  ? 167 ILE F CA  1 
ATOM   780  C C   . ILE A 1 132 ? 178.07800 307.22100 2.42400   1.000 85.65203  ? 167 ILE F C   1 
ATOM   781  O O   . ILE A 1 132 ? 176.87400 307.04000 2.67300   1.000 81.89073  ? 167 ILE F O   1 
ATOM   782  C CB  . ILE A 1 132 ? 179.08700 309.29100 3.56900   1.000 87.16935  ? 167 ILE F CB  1 
ATOM   783  C CG1 . ILE A 1 132 ? 179.92200 309.83800 2.41600   1.000 88.54040  ? 167 ILE F CG1 1 
ATOM   784  C CG2 . ILE A 1 132 ? 179.55500 309.79500 4.94300   1.000 85.20934  ? 167 ILE F CG2 1 
ATOM   785  C CD1 . ILE A 1 132 ? 180.10400 311.32600 2.48000   1.000 87.90808  ? 167 ILE F CD1 1 
ATOM   786  N N   . LYS A 1 133 ? 178.60200 306.90200 1.23200   1.000 87.88968  ? 168 LYS F N   1 
ATOM   787  C CA  . LYS A 1 133 ? 177.76100 306.35400 0.16900   1.000 90.57898  ? 168 LYS F CA  1 
ATOM   788  C C   . LYS A 1 133 ? 177.22000 304.98900 0.53500   1.000 91.15046  ? 168 LYS F C   1 
ATOM   789  O O   . LYS A 1 133 ? 176.08500 304.65300 0.17700   1.000 90.85781  ? 168 LYS F O   1 
ATOM   790  C CB  . LYS A 1 133 ? 178.58500 306.18400 -1.11200  1.000 85.42642  ? 168 LYS F CB  1 
ATOM   791  C CG  . LYS A 1 133 ? 178.53100 307.27900 -2.14500  1.000 87.08511  ? 168 LYS F CG  1 
ATOM   792  C CD  . LYS A 1 133 ? 179.50800 306.94700 -3.27900  1.000 87.01833  ? 168 LYS F CD  1 
ATOM   793  C CE  . LYS A 1 133 ? 178.85700 306.20600 -4.43900  1.000 82.07330  ? 168 LYS F CE  1 
ATOM   794  N NZ  . LYS A 1 133 ? 178.95100 307.05200 -5.66200  1.000 83.67057  ? 168 LYS F NZ  1 
ATOM   795  N N   . SER A 1 134 ? 177.95100 304.26100 1.37000   1.000 90.45204  ? 169 SER F N   1 
ATOM   796  C CA  . SER A 1 134 ? 177.47700 302.95200 1.77700   1.000 92.16492  ? 169 SER F CA  1 
ATOM   797  C C   . SER A 1 134 ? 176.51300 303.07200 2.93400   1.000 90.45390  ? 169 SER F C   1 
ATOM   798  O O   . SER A 1 134 ? 175.48400 302.38600 2.95700   1.000 91.28929  ? 169 SER F O   1 
ATOM   799  C CB  . SER A 1 134 ? 178.65900 302.06200 2.16600   1.000 89.04376  ? 169 SER F CB  1 
ATOM   800  O OG  . SER A 1 134 ? 179.57700 301.94700 1.09300   1.000 91.69950  ? 169 SER F OG  1 
ATOM   801  N N   . ALA A 1 135 ? 176.78200 303.98600 3.86400   1.000 82.35711  ? 170 ALA F N   1 
ATOM   802  C CA  . ALA A 1 135 ? 175.86900 304.07900 4.99300   1.000 86.28015  ? 170 ALA F CA  1 
ATOM   803  C C   . ALA A 1 135 ? 174.50900 304.60800 4.55600   1.000 85.81284  ? 170 ALA F C   1 
ATOM   804  O O   . ALA A 1 135 ? 173.47800 304.18200 5.09000   1.000 86.56786  ? 170 ALA F O   1 
ATOM   805  C CB  . ALA A 1 135 ? 176.46600 304.95600 6.09200   1.000 87.64045  ? 170 ALA F CB  1 
ATOM   806  N N   . LEU A 1 136 ? 174.47100 305.54100 3.59600   1.000 88.09227  ? 171 LEU F N   1 
ATOM   807  C CA  . LEU A 1 136 ? 173.18000 306.02900 3.11600   1.000 93.30707  ? 171 LEU F CA  1 
ATOM   808  C C   . LEU A 1 136 ? 172.67900 305.26500 1.89500   1.000 91.92229  ? 171 LEU F C   1 
ATOM   809  O O   . LEU A 1 136 ? 171.95400 305.83000 1.06100   1.000 90.26231  ? 171 LEU F O   1 
ATOM   810  C CB  . LEU A 1 136 ? 173.28400 307.52200 2.80400   1.000 87.52170  ? 171 LEU F CB  1 
ATOM   811  C CG  . LEU A 1 136 ? 173.57100 308.41600 4.00600   1.000 80.32191  ? 171 LEU F CG  1 
ATOM   812  C CD1 . LEU A 1 136 ? 173.64900 309.86100 3.54300   1.000 79.22109  ? 171 LEU F CD1 1 
ATOM   813  C CD2 . LEU A 1 136 ? 172.49400 308.22900 5.08500   1.000 79.31366  ? 171 LEU F CD2 1 
ATOM   814  N N   . LEU A 1 137 ? 172.97200 303.97300 1.80800   1.000 95.85540  ? 172 LEU F N   1 
ATOM   815  C CA  . LEU A 1 137 ? 172.53900 303.20000 0.65200   1.000 98.05728  ? 172 LEU F CA  1 
ATOM   816  C C   . LEU A 1 137 ? 171.08400 302.76200 0.77700   1.000 92.77605  ? 172 LEU F C   1 
ATOM   817  O O   . LEU A 1 137 ? 170.37400 302.70000 -0.23200  1.000 90.77058  ? 172 LEU F O   1 
ATOM   818  C CB  . LEU A 1 137 ? 173.48800 302.02600 0.41100   1.000 96.03726  ? 172 LEU F CB  1 
ATOM   819  C CG  . LEU A 1 137 ? 173.12100 301.21400 -0.82400  1.000 95.96436  ? 172 LEU F CG  1 
ATOM   820  C CD1 . LEU A 1 137 ? 173.25200 302.11400 -2.06100  1.000 89.39265  ? 172 LEU F CD1 1 
ATOM   821  C CD2 . LEU A 1 137 ? 174.04900 300.01600 -0.95000  1.000 92.37988  ? 172 LEU F CD2 1 
ATOM   822  N N   . SER A 1 138 ? 170.60200 302.53500 2.00300   1.000 94.11710  ? 173 SER F N   1 
ATOM   823  C CA  . SER A 1 138 ? 169.26200 302.01100 2.20100   1.000 94.94820  ? 173 SER F CA  1 
ATOM   824  C C   . SER A 1 138 ? 168.35000 302.97000 2.94900   1.000 94.78271  ? 173 SER F C   1 
ATOM   825  O O   . SER A 1 138 ? 167.12800 302.85000 2.81300   1.000 92.96922  ? 173 SER F O   1 
ATOM   826  C CB  . SER A 1 138 ? 169.31500 300.68000 2.97100   1.000 98.18393  ? 173 SER F CB  1 
ATOM   827  O OG  . SER A 1 138 ? 170.10500 299.70800 2.30200   1.000 102.38704 ? 173 SER F OG  1 
ATOM   828  N N   . THR A 1 139 ? 168.88600 303.88100 3.75800   1.000 93.46979  ? 174 THR F N   1 
ATOM   829  C CA  . THR A 1 139 ? 168.06800 304.81100 4.53400   1.000 91.63871  ? 174 THR F CA  1 
ATOM   830  C C   . THR A 1 139 ? 168.53800 306.22100 4.18500   1.000 90.24943  ? 174 THR F C   1 
ATOM   831  O O   . THR A 1 139 ? 169.60900 306.41600 3.60000   1.000 87.35222  ? 174 THR F O   1 
ATOM   832  C CB  . THR A 1 139 ? 168.08800 304.56400 6.05500   1.000 90.23003  ? 174 THR F CB  1 
ATOM   833  O OG1 . THR A 1 139 ? 169.43400 304.49100 6.52500   1.000 88.93041  ? 174 THR F OG1 1 
ATOM   834  C CG2 . THR A 1 139 ? 167.33400 303.28800 6.42400   1.000 94.39192  ? 174 THR F CG2 1 
ATOM   835  N N   . ASN A 1 140 ? 167.74400 307.21200 4.59400   1.000 90.26093  ? 175 ASN F N   1 
ATOM   836  C CA  . ASN A 1 140 ? 168.10100 308.61200 4.37100   1.000 88.98208  ? 175 ASN F CA  1 
ATOM   837  C C   . ASN A 1 140 ? 169.10900 309.13600 5.39800   1.000 84.75796  ? 175 ASN F C   1 
ATOM   838  O O   . ASN A 1 140 ? 169.99600 309.91900 5.04400   1.000 83.59879  ? 175 ASN F O   1 
ATOM   839  C CB  . ASN A 1 140 ? 166.83200 309.47500 4.35400   1.000 90.22690  ? 175 ASN F CB  1 
ATOM   840  C CG  . ASN A 1 140 ? 165.79400 309.04700 5.40900   1.000 97.59298  ? 175 ASN F CG  1 
ATOM   841  O OD1 . ASN A 1 140 ? 165.70800 307.86700 5.78100   1.000 100.22289 ? 175 ASN F OD1 1 
ATOM   842  N ND2 . ASN A 1 140 ? 164.98600 310.00600 5.87300   1.000 97.06597  ? 175 ASN F ND2 1 
ATOM   843  N N   . LYS A 1 141 ? 168.98500 308.74800 6.66600   1.000 85.92689  ? 176 LYS F N   1 
ATOM   844  C CA  . LYS A 1 141 ? 169.88100 309.20700 7.72000   1.000 84.32663  ? 176 LYS F CA  1 
ATOM   845  C C   . LYS A 1 141 ? 170.71100 308.04700 8.26200   1.000 81.07540  ? 176 LYS F C   1 
ATOM   846  O O   . LYS A 1 141 ? 170.25700 306.90300 8.29700   1.000 81.99213  ? 176 LYS F O   1 
ATOM   847  C CB  . LYS A 1 141 ? 169.09400 309.90000 8.84200   1.000 83.06723  ? 176 LYS F CB  1 
ATOM   848  C CG  . LYS A 1 141 ? 168.24500 308.98900 9.73600   1.000 85.22248  ? 176 LYS F CG  1 
ATOM   849  C CD  . LYS A 1 141 ? 167.06300 309.78800 10.30300  1.000 86.42896  ? 176 LYS F CD  1 
ATOM   850  C CE  . LYS A 1 141 ? 166.38900 310.59800 9.17100   1.000 90.57256  ? 176 LYS F CE  1 
ATOM   851  N NZ  . LYS A 1 141 ? 165.22300 311.43100 9.59800   1.000 80.47924  ? 176 LYS F NZ  1 
ATOM   852  N N   . ALA A 1 142 ? 171.93700 308.35100 8.68500   1.000 82.37899  ? 177 ALA F N   1 
ATOM   853  C CA  . ALA A 1 142 ? 172.80800 307.31000 9.22200   1.000 81.77840  ? 177 ALA F CA  1 
ATOM   854  C C   . ALA A 1 142 ? 174.01500 307.94800 9.88700   1.000 81.91219  ? 177 ALA F C   1 
ATOM   855  O O   . ALA A 1 142 ? 174.56800 308.91900 9.37400   1.000 80.56470  ? 177 ALA F O   1 
ATOM   856  C CB  . ALA A 1 142 ? 173.27700 306.35200 8.12000   1.000 79.77927  ? 177 ALA F CB  1 
ATOM   857  N N   . VAL A 1 143 ? 174.44600 307.36600 11.00100  1.000 84.27550  ? 178 VAL F N   1 
ATOM   858  C CA  . VAL A 1 143 ? 175.64800 307.81400 11.69200  1.000 80.56294  ? 178 VAL F CA  1 
ATOM   859  C C   . VAL A 1 143 ? 176.84900 307.14200 11.05300  1.000 82.80932  ? 178 VAL F C   1 
ATOM   860  O O   . VAL A 1 143 ? 176.83100 305.94300 10.76700  1.000 89.96706  ? 178 VAL F O   1 
ATOM   861  C CB  . VAL A 1 143 ? 175.58500 307.49700 13.19400  1.000 82.04694  ? 178 VAL F CB  1 
ATOM   862  C CG1 . VAL A 1 143 ? 176.89200 307.92000 13.84800  1.000 81.60018  ? 178 VAL F CG1 1 
ATOM   863  C CG2 . VAL A 1 143 ? 174.39000 308.17400 13.83500  1.000 78.82416  ? 178 VAL F CG2 1 
ATOM   864  N N   . VAL A 1 144 ? 177.89300 307.92200 10.81900  1.000 80.07491  ? 179 VAL F N   1 
ATOM   865  C CA  . VAL A 1 144 ? 179.10300 307.46000 10.16200  1.000 80.91040  ? 179 VAL F CA  1 
ATOM   866  C C   . VAL A 1 144 ? 180.30300 307.88300 10.99700  1.000 86.16037  ? 179 VAL F C   1 
ATOM   867  O O   . VAL A 1 144 ? 180.43300 309.05900 11.36400  1.000 84.50092  ? 179 VAL F O   1 
ATOM   868  C CB  . VAL A 1 144 ? 179.21400 307.98300 8.72100   1.000 79.53768  ? 179 VAL F CB  1 
ATOM   869  C CG1 . VAL A 1 144 ? 180.51100 307.51200 8.09400   1.000 81.10419  ? 179 VAL F CG1 1 
ATOM   870  C CG2 . VAL A 1 144 ? 178.02500 307.51700 7.91700   1.000 80.05940  ? 179 VAL F CG2 1 
ATOM   871  N N   . SER A 1 145 ? 181.17000 306.92200 11.29300  1.000 85.04708  ? 180 SER F N   1 
ATOM   872  C CA  . SER A 1 145 ? 182.43000 307.16300 11.98500  1.000 84.83502  ? 180 SER F CA  1 
ATOM   873  C C   . SER A 1 145 ? 183.44400 307.47100 10.89600  1.000 85.07262  ? 180 SER F C   1 
ATOM   874  O O   . SER A 1 145 ? 183.75300 306.62100 10.05400  1.000 86.16795  ? 180 SER F O   1 
ATOM   875  C CB  . SER A 1 145 ? 182.85400 305.97000 12.83200  1.000 86.72044  ? 180 SER F CB  1 
ATOM   876  O OG  . SER A 1 145 ? 181.90400 305.70900 13.84600  1.000 102.49940 ? 180 SER F OG  1 
ATOM   877  N N   . LEU A 1 146 ? 183.90600 308.71300 10.86900  1.000 82.43900  ? 181 LEU F N   1 
ATOM   878  C CA  . LEU A 1 146 ? 184.80600 309.09700 9.80800   1.000 84.93679  ? 181 LEU F CA  1 
ATOM   879  C C   . LEU A 1 146 ? 186.18800 308.51400 10.12100  1.000 87.55106  ? 181 LEU F C   1 
ATOM   880  O O   . LEU A 1 146 ? 186.42200 307.97600 11.20900  1.000 91.18666  ? 181 LEU F O   1 
ATOM   881  C CB  . LEU A 1 146 ? 184.80500 310.62200 9.74500   1.000 84.47836  ? 181 LEU F CB  1 
ATOM   882  C CG  . LEU A 1 146 ? 183.66200 311.24500 8.91300   1.000 86.38769  ? 181 LEU F CG  1 
ATOM   883  C CD1 . LEU A 1 146 ? 183.34500 312.66000 9.42600   1.000 81.16399  ? 181 LEU F CD1 1 
ATOM   884  C CD2 . LEU A 1 146 ? 183.79800 311.21200 7.39600   1.000 83.05134  ? 181 LEU F CD2 1 
ATOM   885  N N   . SER A 1 147 ? 187.15200 308.67600 9.21100   1.000 83.58902  ? 182 SER F N   1 
ATOM   886  C CA  . SER A 1 147 ? 188.48600 308.12900 9.44700   1.000 87.07153  ? 182 SER F CA  1 
ATOM   887  C C   . SER A 1 147 ? 189.39100 309.07300 10.22200  1.000 89.09239  ? 182 SER F C   1 
ATOM   888  O O   . SER A 1 147 ? 190.62500 308.98700 10.11600  1.000 87.50764  ? 182 SER F O   1 
ATOM   889  C CB  . SER A 1 147 ? 189.12600 307.71900 8.12100   1.000 81.44354  ? 182 SER F CB  1 
ATOM   890  O OG  . SER A 1 147 ? 189.25900 308.82000 7.24600   1.000 79.91354  ? 182 SER F OG  1 
ATOM   891  N N   . ASN A 1 148 ? 188.80500 309.93500 11.04600  1.000 87.37136  ? 183 ASN F N   1 
ATOM   892  C CA  . ASN A 1 148 ? 189.56200 310.85400 11.87900  1.000 85.59386  ? 183 ASN F CA  1 
ATOM   893  C C   . ASN A 1 148 ? 188.96100 310.87900 13.27300  1.000 86.01960  ? 183 ASN F C   1 
ATOM   894  O O   . ASN A 1 148 ? 189.25800 311.79700 14.04600  1.000 85.78847  ? 183 ASN F O   1 
ATOM   895  C CB  . ASN A 1 148 ? 189.57800 312.25900 11.28400  1.000 84.24010  ? 183 ASN F CB  1 
ATOM   896  C CG  . ASN A 1 148 ? 188.22800 312.92300 11.35400  1.000 83.83576  ? 183 ASN F CG  1 
ATOM   897  O OD1 . ASN A 1 148 ? 187.19500 312.25800 11.31300  1.000 85.27860  ? 183 ASN F OD1 1 
ATOM   898  N ND2 . ASN A 1 148 ? 188.22400 314.24100 11.43400  1.000 84.05108  ? 183 ASN F ND2 1 
ATOM   899  N N   . GLY A 1 149 ? 188.10700 309.91200 13.60100  1.000 89.03636  ? 184 GLY F N   1 
ATOM   900  C CA  . GLY A 1 149 ? 187.51300 309.80800 14.91800  1.000 92.30186  ? 184 GLY F CA  1 
ATOM   901  C C   . GLY A 1 149 ? 186.27300 310.64100 15.16100  1.000 88.46411  ? 184 GLY F C   1 
ATOM   902  O O   . GLY A 1 149 ? 185.75800 310.63100 16.28600  1.000 92.71018  ? 184 GLY F O   1 
ATOM   903  N N   . VAL A 1 150 ? 185.73400 311.30100 14.14000  1.000 85.06803  ? 185 VAL F N   1 
ATOM   904  C CA  . VAL A 1 150 ? 184.56000 312.16500 14.27500  1.000 82.52379  ? 185 VAL F CA  1 
ATOM   905  C C   . VAL A 1 150 ? 183.34200 311.36800 13.83400  1.000 79.90897  ? 185 VAL F C   1 
ATOM   906  O O   . VAL A 1 150 ? 183.27000 310.89900 12.69200  1.000 82.02667  ? 185 VAL F O   1 
ATOM   907  C CB  . VAL A 1 150 ? 184.71100 313.47800 13.49400  1.000 83.47754  ? 185 VAL F CB  1 
ATOM   908  C CG1 . VAL A 1 150 ? 183.46800 314.34700 13.69100  1.000 78.87205  ? 185 VAL F CG1 1 
ATOM   909  C CG2 . VAL A 1 150 ? 185.93900 314.23500 13.97700  1.000 80.96001  ? 185 VAL F CG2 1 
ATOM   910  N N   . SER A 1 151 ? 182.40800 311.19500 14.76800  1.000 77.40061  ? 186 SER F N   1 
ATOM   911  C CA  . SER A 1 151 ? 181.13800 310.50300 14.56200  1.000 82.06001  ? 186 SER F CA  1 
ATOM   912  C C   . SER A 1 151 ? 180.03900 311.45100 14.09200  1.000 81.46728  ? 186 SER F C   1 
ATOM   913  O O   . SER A 1 151 ? 179.32400 312.04700 14.89600  1.000 85.81961  ? 186 SER F O   1 
ATOM   914  C CB  . SER A 1 151 ? 180.74900 309.78200 15.84700  1.000 79.89609  ? 186 SER F CB  1 
ATOM   915  O OG  . SER A 1 151 ? 179.54900 309.05900 15.66600  1.000 88.85608  ? 186 SER F OG  1 
ATOM   916  N N   . VAL A 1 152 ? 179.94400 311.63200 12.75600  1.000 81.96480  ? 187 VAL F N   1 
ATOM   917  C CA  . VAL A 1 152 ? 179.03300 312.60200 12.15700  1.000 79.63039  ? 187 VAL F CA  1 
ATOM   918  C C   . VAL A 1 152 ? 177.71400 311.93700 11.79000  1.000 79.79983  ? 187 VAL F C   1 
ATOM   919  O O   . VAL A 1 152 ? 177.63100 310.73500 11.52900  1.000 80.97986  ? 187 VAL F O   1 
ATOM   920  C CB  . VAL A 1 152 ? 179.62800 313.24200 10.88800  1.000 73.28523  ? 187 VAL F CB  1 
ATOM   921  C CG1 . VAL A 1 152 ? 180.86200 314.07000 11.20200  1.000 76.34055  ? 187 VAL F CG1 1 
ATOM   922  C CG2 . VAL A 1 152 ? 179.89800 312.16300 9.85000   1.000 75.38831  ? 187 VAL F CG2 1 
ATOM   923  N N   . LEU A 1 153 ? 176.67100 312.75100 11.71700  1.000 77.46630  ? 188 LEU F N   1 
ATOM   924  C CA  . LEU A 1 153 ? 175.36100 312.28700 11.30800  1.000 72.65383  ? 188 LEU F CA  1 
ATOM   925  C C   . LEU A 1 153 ? 175.24200 312.70000 9.85500   1.000 75.22951  ? 188 LEU F C   1 
ATOM   926  O O   . LEU A 1 153 ? 175.48700 313.86900 9.52000   1.000 73.69495  ? 188 LEU F O   1 
ATOM   927  C CB  . LEU A 1 153 ? 174.22800 312.90900 12.12400  1.000 70.79543  ? 188 LEU F CB  1 
ATOM   928  C CG  . LEU A 1 153 ? 173.80400 312.23300 13.42200  1.000 76.02159  ? 188 LEU F CG  1 
ATOM   929  C CD1 . LEU A 1 153 ? 173.21100 313.24200 14.38900  1.000 74.85062  ? 188 LEU F CD1 1 
ATOM   930  C CD2 . LEU A 1 153 ? 172.81000 311.12300 13.14200  1.000 73.07930  ? 188 LEU F CD2 1 
ATOM   931  N N   . THR A 1 154 ? 175.03800 311.72500 8.98100   1.000 74.71031  ? 189 THR F N   1 
ATOM   932  C CA  . THR A 1 154 ? 174.98000 311.96300 7.55700   1.000 69.92384  ? 189 THR F CA  1 
ATOM   933  C C   . THR A 1 154 ? 173.52500 311.83000 7.15000   1.000 72.95621  ? 189 THR F C   1 
ATOM   934  O O   . THR A 1 154 ? 172.76600 311.05600 7.74500   1.000 75.96805  ? 189 THR F O   1 
ATOM   935  C CB  . THR A 1 154 ? 175.85500 311.00400 6.76300   1.000 71.67075  ? 189 THR F CB  1 
ATOM   936  O OG1 . THR A 1 154 ? 177.19500 311.05300 7.27000   1.000 75.46024  ? 189 THR F OG1 1 
ATOM   937  C CG2 . THR A 1 154 ? 175.86600 311.43400 5.32100   1.000 69.74085  ? 189 THR F CG2 1 
ATOM   938  N N   . SER A 1 155 ? 173.14200 312.59000 6.14200   1.000 70.80208  ? 190 SER F N   1 
ATOM   939  C CA  . SER A 1 155 ? 171.77900 312.53600 5.65200   1.000 71.73389  ? 190 SER F CA  1 
ATOM   940  C C   . SER A 1 155 ? 171.80900 312.65900 4.13900   1.000 71.58131  ? 190 SER F C   1 
ATOM   941  O O   . SER A 1 155 ? 172.70700 313.29000 3.58000   1.000 70.71859  ? 190 SER F O   1 
ATOM   942  C CB  . SER A 1 155 ? 170.93300 313.64700 6.27100   1.000 73.49614  ? 190 SER F CB  1 
ATOM   943  O OG  . SER A 1 155 ? 169.57500 313.27500 6.28800   1.000 81.75719  ? 190 SER F OG  1 
ATOM   944  N N   . LYS A 1 156 ? 170.84000 312.02200 3.48600   1.000 69.77801  ? 191 LYS F N   1 
ATOM   945  C CA  . LYS A 1 156 ? 170.64500 312.08000 2.03300   1.000 70.66496  ? 191 LYS F CA  1 
ATOM   946  C C   . LYS A 1 156 ? 169.30400 312.76100 1.79300   1.000 69.55947  ? 191 LYS F C   1 
ATOM   947  O O   . LYS A 1 156 ? 168.25200 312.15200 2.01000   1.000 70.70203  ? 191 LYS F O   1 
ATOM   948  C CB  . LYS A 1 156 ? 170.72000 310.70700 1.36400   1.000 77.51886  ? 191 LYS F CB  1 
ATOM   949  C CG  . LYS A 1 156 ? 170.51900 310.78600 -0.16700  1.000 77.36259  ? 191 LYS F CG  1 
ATOM   950  C CD  . LYS A 1 156 ? 170.99400 309.53600 -0.91400  1.000 84.78262  ? 191 LYS F CD  1 
ATOM   951  C CE  . LYS A 1 156 ? 170.27800 308.26400 -0.50900  1.000 83.91906  ? 191 LYS F CE  1 
ATOM   952  N NZ  . LYS A 1 156 ? 170.85200 307.11500 -1.25900  1.000 83.05199  ? 191 LYS F NZ  1 
ATOM   953  N N   . VAL A 1 157 ? 169.33000 314.06500 1.51300   1.000 62.65301  ? 192 VAL F N   1 
ATOM   954  C CA  . VAL A 1 157 ? 168.06400 314.79600 1.43400   1.000 64.84374  ? 192 VAL F CA  1 
ATOM   955  C C   . VAL A 1 157 ? 167.42100 314.80200 0.04500   1.000 65.29947  ? 192 VAL F C   1 
ATOM   956  O O   . VAL A 1 157 ? 166.24900 315.17500 -0.08500  1.000 65.43826  ? 192 VAL F O   1 
ATOM   957  C CB  . VAL A 1 157 ? 168.24100 316.24600 1.93400   1.000 66.39879  ? 192 VAL F CB  1 
ATOM   958  C CG1 . VAL A 1 157 ? 168.73100 316.25800 3.38900   1.000 65.27228  ? 192 VAL F CG1 1 
ATOM   959  C CG2 . VAL A 1 157 ? 169.19700 317.01100 1.03700   1.000 64.63527  ? 192 VAL F CG2 1 
ATOM   960  N N   . LEU A 1 158 ? 168.15900 314.47000 -1.00200  1.000 66.76998  ? 193 LEU F N   1 
ATOM   961  C CA  . LEU A 1 158 ? 167.60000 314.49200 -2.34400  1.000 68.03815  ? 193 LEU F CA  1 
ATOM   962  C C   . LEU A 1 158 ? 168.31200 313.42300 -3.15900  1.000 72.78635  ? 193 LEU F C   1 
ATOM   963  O O   . LEU A 1 158 ? 169.52900 313.25400 -3.04000  1.000 71.62336  ? 193 LEU F O   1 
ATOM   964  C CB  . LEU A 1 158 ? 167.71700 315.87800 -2.99000  1.000 67.94087  ? 193 LEU F CB  1 
ATOM   965  C CG  . LEU A 1 158 ? 167.08000 316.14600 -4.35800  1.000 66.48446  ? 193 LEU F CG  1 
ATOM   966  C CD1 . LEU A 1 158 ? 165.57600 315.98400 -4.33700  1.000 64.25912  ? 193 LEU F CD1 1 
ATOM   967  C CD2 . LEU A 1 158 ? 167.44900 317.54800 -4.82400  1.000 61.48915  ? 193 LEU F CD2 1 
ATOM   968  N N   . ASP A 1 159 ? 167.55600 312.70600 -3.98200  1.000 74.79386  ? 194 ASP F N   1 
ATOM   969  C CA  . ASP A 1 159 ? 168.09100 311.60900 -4.79000  1.000 76.12338  ? 194 ASP F CA  1 
ATOM   970  C C   . ASP A 1 159 ? 167.79600 311.88900 -6.24700  1.000 75.88757  ? 194 ASP F C   1 
ATOM   971  O O   . ASP A 1 159 ? 166.72100 311.56100 -6.75500  1.000 79.32533  ? 194 ASP F O   1 
ATOM   972  C CB  . ASP A 1 159 ? 167.53600 310.24900 -4.40700  1.000 78.26078  ? 194 ASP F CB  1 
ATOM   973  C CG  . ASP A 1 159 ? 168.36900 309.10000 -4.98500  1.000 77.51767  ? 194 ASP F CG  1 
ATOM   974  O OD1 . ASP A 1 159 ? 169.09900 309.31900 -5.98300  1.000 77.66520  ? 194 ASP F OD1 1 
ATOM   975  O OD2 . ASP A 1 159 ? 168.29300 307.97800 -4.44600  1.000 80.12687  ? 194 ASP F OD2 1 
ATOM   976  N N   . LEU A 1 160 ? 168.74300 312.55500 -6.89600  1.000 72.41880  ? 195 LEU F N   1 
ATOM   977  C CA  . LEU A 1 160 ? 168.61500 312.82400 -8.31500  1.000 74.43260  ? 195 LEU F CA  1 
ATOM   978  C C   . LEU A 1 160 ? 169.16100 311.69100 -9.16700  1.000 75.62887  ? 195 LEU F C   1 
ATOM   979  O O   . LEU A 1 160 ? 168.73300 311.54800 -10.31500 1.000 76.12857  ? 195 LEU F O   1 
ATOM   980  C CB  . LEU A 1 160 ? 169.31300 314.13500 -8.68400  1.000 62.59535  ? 195 LEU F CB  1 
ATOM   981  C CG  . LEU A 1 160 ? 168.59400 315.38500 -8.17900  1.000 70.96914  ? 195 LEU F CG  1 
ATOM   982  C CD1 . LEU A 1 160 ? 169.33200 316.63100 -8.61200  1.000 64.77493  ? 195 LEU F CD1 1 
ATOM   983  C CD2 . LEU A 1 160 ? 167.18900 315.40300 -8.75500  1.000 67.81385  ? 195 LEU F CD2 1 
ATOM   984  N N   . LYS A 1 161 ? 170.11500 310.89400 -8.66600  1.000 77.74132  ? 196 LYS F N   1 
ATOM   985  C CA  . LYS A 1 161 ? 170.58400 309.77700 -9.48200  1.000 82.89715  ? 196 LYS F CA  1 
ATOM   986  C C   . LYS A 1 161 ? 169.48200 308.76100 -9.71900  1.000 80.47300  ? 196 LYS F C   1 
ATOM   987  O O   . LYS A 1 161 ? 169.27200 308.31800 -10.85300 1.000 77.99837  ? 196 LYS F O   1 
ATOM   988  C CB  . LYS A 1 161 ? 171.76400 309.06700 -8.81000  1.000 78.74758  ? 196 LYS F CB  1 
ATOM   989  C CG  . LYS A 1 161 ? 172.30900 307.91800 -9.65800  1.000 84.97560  ? 196 LYS F CG  1 
ATOM   990  C CD  . LYS A 1 161 ? 173.57600 307.26600 -9.10600  1.000 85.05081  ? 196 LYS F CD  1 
ATOM   991  C CE  . LYS A 1 161 ? 173.59800 305.76600 -9.44900  1.000 88.42989  ? 196 LYS F CE  1 
ATOM   992  N NZ  . LYS A 1 161 ? 174.53600 305.39300 -10.55400 1.000 90.64453  ? 196 LYS F NZ  1 
ATOM   993  N N   . ASN A 1 162 ? 168.68300 308.48800 -8.69200  1.000 82.24629  ? 197 ASN F N   1 
ATOM   994  C CA  . ASN A 1 162 ? 167.59700 307.53200 -8.85000  1.000 83.21169  ? 197 ASN F CA  1 
ATOM   995  C C   . ASN A 1 162 ? 166.53700 308.04100 -9.81600  1.000 83.66373  ? 197 ASN F C   1 
ATOM   996  O O   . ASN A 1 162 ? 166.13800 307.32200 -10.74400 1.000 90.33722  ? 197 ASN F O   1 
ATOM   997  C CB  . ASN A 1 162 ? 166.99300 307.21700 -7.47700  1.000 86.58506  ? 197 ASN F CB  1 
ATOM   998  C CG  . ASN A 1 162 ? 165.81100 306.27300 -7.55700  1.000 92.70997  ? 197 ASN F CG  1 
ATOM   999  O OD1 . ASN A 1 162 ? 165.97700 305.05600 -7.54300  1.000 95.71892  ? 197 ASN F OD1 1 
ATOM   1000 N ND2 . ASN A 1 162 ? 164.60600 306.83100 -7.64100  1.000 98.27700  ? 197 ASN F ND2 1 
ATOM   1001 N N   . TYR A 1 163 ? 166.23000 309.33100 -9.75200  1.000 77.87637  ? 198 TYR F N   1 
ATOM   1002 C CA  . TYR A 1 163 ? 165.16900 309.85200 -10.59800 1.000 77.63386  ? 198 TYR F CA  1 
ATOM   1003 C C   . TYR A 1 163 ? 165.62000 310.00400 -12.03200 1.000 77.47622  ? 198 TYR F C   1 
ATOM   1004 O O   . TYR A 1 163 ? 164.88000 309.66600 -12.95800 1.000 79.52887  ? 198 TYR F O   1 
ATOM   1005 C CB  . TYR A 1 163 ? 164.71900 311.22000 -10.07400 1.000 72.69363  ? 198 TYR F CB  1 
ATOM   1006 C CG  . TYR A 1 163 ? 163.46600 311.71800 -10.73700 1.000 70.22706  ? 198 TYR F CG  1 
ATOM   1007 C CD1 . TYR A 1 163 ? 162.21000 311.35600 -10.27100 1.000 73.24697  ? 198 TYR F CD1 1 
ATOM   1008 C CD2 . TYR A 1 163 ? 163.54200 312.50900 -11.87000 1.000 68.13386  ? 198 TYR F CD2 1 
ATOM   1009 C CE1 . TYR A 1 163 ? 161.07000 311.79900 -10.89600 1.000 72.09798  ? 198 TYR F CE1 1 
ATOM   1010 C CE2 . TYR A 1 163 ? 162.40700 312.95400 -12.50500 1.000 68.29849  ? 198 TYR F CE2 1 
ATOM   1011 C CZ  . TYR A 1 163 ? 161.17400 312.59500 -12.01600 1.000 69.58337  ? 198 TYR F CZ  1 
ATOM   1012 O OH  . TYR A 1 163 ? 160.02900 313.03500 -12.63700 1.000 75.03295  ? 198 TYR F OH  1 
ATOM   1013 N N   . ILE A 1 164 ? 166.83800 310.47300 -12.23100 1.000 74.61318  ? 199 ILE F N   1 
ATOM   1014 C CA  . ILE A 1 164 ? 167.31500 310.70000 -13.57700 1.000 78.12570  ? 199 ILE F CA  1 
ATOM   1015 C C   . ILE A 1 164 ? 167.55700 309.36700 -14.25700 1.000 81.78278  ? 199 ILE F C   1 
ATOM   1016 O O   . ILE A 1 164 ? 167.17300 309.18700 -15.41600 1.000 80.94399  ? 199 ILE F O   1 
ATOM   1017 C CB  . ILE A 1 164 ? 168.54300 311.62800 -13.54100 1.000 74.42665  ? 199 ILE F CB  1 
ATOM   1018 C CG1 . ILE A 1 164 ? 168.13000 313.00100 -12.97400 1.000 74.83580  ? 199 ILE F CG1 1 
ATOM   1019 C CG2 . ILE A 1 164 ? 169.12500 311.82700 -14.93100 1.000 72.77637  ? 199 ILE F CG2 1 
ATOM   1020 C CD1 . ILE A 1 164 ? 169.19900 314.04300 -12.95600 1.000 69.70847  ? 199 ILE F CD1 1 
ATOM   1021 N N   . ASP A 1 165 ? 168.16700 308.40100 -13.54700 1.000 82.43809  ? 200 ASP F N   1 
ATOM   1022 C CA  . ASP A 1 165 ? 168.52200 307.12200 -14.15500 1.000 86.12951  ? 200 ASP F CA  1 
ATOM   1023 C C   . ASP A 1 165 ? 167.30500 306.23100 -14.36800 1.000 84.79090  ? 200 ASP F C   1 
ATOM   1024 O O   . ASP A 1 165 ? 167.32300 305.39200 -15.27100 1.000 86.32271  ? 200 ASP F O   1 
ATOM   1025 C CB  . ASP A 1 165 ? 169.57700 306.40500 -13.30100 1.000 83.54692  ? 200 ASP F CB  1 
ATOM   1026 C CG  . ASP A 1 165 ? 170.91100 307.12800 -13.29000 1.000 87.32908  ? 200 ASP F CG  1 
ATOM   1027 O OD1 . ASP A 1 165 ? 170.93000 308.33600 -13.60000 1.000 91.30284  ? 200 ASP F OD1 1 
ATOM   1028 O OD2 . ASP A 1 165 ? 171.92700 306.51100 -12.90800 1.000 86.29502  ? 200 ASP F OD2 1 
ATOM   1029 N N   . LYS A 1 166 ? 166.23700 306.40800 -13.59400 1.000 84.20922  ? 201 LYS F N   1 
ATOM   1030 C CA  . LYS A 1 166 ? 165.07400 305.55200 -13.77200 1.000 81.43030  ? 201 LYS F CA  1 
ATOM   1031 C C   . LYS A 1 166 ? 164.03000 306.17800 -14.69000 1.000 83.59173  ? 201 LYS F C   1 
ATOM   1032 O O   . LYS A 1 166 ? 163.42900 305.48100 -15.51100 1.000 87.84597  ? 201 LYS F O   1 
ATOM   1033 C CB  . LYS A 1 166 ? 164.43900 305.22700 -12.41500 1.000 84.84928  ? 201 LYS F CB  1 
ATOM   1034 C CG  . LYS A 1 166 ? 165.21100 304.22200 -11.56300 1.000 89.16126  ? 201 LYS F CG  1 
ATOM   1035 C CD  . LYS A 1 166 ? 165.80100 303.11000 -12.42500 1.000 91.47477  ? 201 LYS F CD  1 
ATOM   1036 C CE  . LYS A 1 166 ? 166.00600 301.80700 -11.64100 1.000 93.26468  ? 201 LYS F CE  1 
ATOM   1037 N NZ  . LYS A 1 166 ? 165.46200 300.61200 -12.37700 1.000 86.31510  ? 201 LYS F NZ  1 
ATOM   1038 N N   . GLN A 1 167 ? 163.82000 307.48500 -14.58600 1.000 80.66705  ? 202 GLN F N   1 
ATOM   1039 C CA  . GLN A 1 167 ? 162.75200 308.18500 -15.28600 1.000 80.86198  ? 202 GLN F CA  1 
ATOM   1040 C C   . GLN A 1 167 ? 163.20100 309.01200 -16.48700 1.000 78.12368  ? 202 GLN F C   1 
ATOM   1041 O O   . GLN A 1 167 ? 162.37000 309.34000 -17.33700 1.000 80.12851  ? 202 GLN F O   1 
ATOM   1042 C CB  . GLN A 1 167 ? 161.99900 309.05400 -14.28800 1.000 77.95092  ? 202 GLN F CB  1 
ATOM   1043 C CG  . GLN A 1 167 ? 161.62000 308.23900 -13.05900 1.000 80.23233  ? 202 GLN F CG  1 
ATOM   1044 C CD  . GLN A 1 167 ? 160.19700 307.74700 -13.12800 1.000 88.90482  ? 202 GLN F CD  1 
ATOM   1045 O OE1 . GLN A 1 167 ? 159.65200 307.56300 -14.21500 1.000 89.33918  ? 202 GLN F OE1 1 
ATOM   1046 N NE2 . GLN A 1 167 ? 159.57800 307.53600 -11.96700 1.000 90.27753  ? 202 GLN F NE2 1 
ATOM   1047 N N   . LEU A 1 168 ? 164.46700 309.38400 -16.55600 1.000 78.26913  ? 203 LEU F N   1 
ATOM   1048 C CA  . LEU A 1 168 ? 165.04600 310.28000 -17.55600 1.000 82.44704  ? 203 LEU F CA  1 
ATOM   1049 C C   . LEU A 1 168 ? 165.91900 309.57600 -18.58800 1.000 88.33931  ? 203 LEU F C   1 
ATOM   1050 O O   . LEU A 1 168 ? 165.89500 309.95500 -19.76200 1.000 88.34791  ? 203 LEU F O   1 
ATOM   1051 C CB  . LEU A 1 168 ? 165.82500 311.41000 -16.88500 1.000 81.42781  ? 203 LEU F CB  1 
ATOM   1052 C CG  . LEU A 1 168 ? 164.93000 312.65700 -16.76600 1.000 76.98450  ? 203 LEU F CG  1 
ATOM   1053 C CD1 . LEU A 1 168 ? 163.54200 312.28700 -16.22600 1.000 67.87240  ? 203 LEU F CD1 1 
ATOM   1054 C CD2 . LEU A 1 168 ? 165.54900 313.80300 -15.95700 1.000 72.98365  ? 203 LEU F CD2 1 
ATOM   1055 N N   . LEU A 1 169 ? 166.73000 308.59900 -18.18400 1.000 90.44839  ? 204 LEU F N   1 
ATOM   1056 C CA  . LEU A 1 169 ? 167.62900 307.92700 -19.12300 1.000 95.89430  ? 204 LEU F CA  1 
ATOM   1057 C C   . LEU A 1 169 ? 166.91200 307.23200 -20.26800 1.000 96.14039  ? 204 LEU F C   1 
ATOM   1058 O O   . LEU A 1 169 ? 167.38100 307.35200 -21.41000 1.000 98.68961  ? 204 LEU F O   1 
ATOM   1059 C CB  . LEU A 1 169 ? 168.46000 306.87500 -18.40400 1.000 96.09148  ? 204 LEU F CB  1 
ATOM   1060 C CG  . LEU A 1 169 ? 169.57400 307.22500 -17.42600 1.000 94.14121  ? 204 LEU F CG  1 
ATOM   1061 C CD1 . LEU A 1 169 ? 170.24800 305.93200 -16.97700 1.000 93.33042  ? 204 LEU F CD1 1 
ATOM   1062 C CD2 . LEU A 1 169 ? 170.54400 308.15500 -18.13400 1.000 97.72032  ? 204 LEU F CD2 1 
ATOM   1063 N N   . PRO A 1 170 ? 165.79700 306.52900 -20.06500 1.000 97.86832  ? 205 PRO F N   1 
ATOM   1064 C CA  . PRO A 1 170 ? 165.06100 305.98500 -21.22400 1.000 97.28624  ? 205 PRO F CA  1 
ATOM   1065 C C   . PRO A 1 170 ? 164.59300 307.05800 -22.20300 1.000 96.26056  ? 205 PRO F C   1 
ATOM   1066 O O   . PRO A 1 170 ? 164.24300 306.71200 -23.33600 1.000 98.20683  ? 205 PRO F O   1 
ATOM   1067 C CB  . PRO A 1 170 ? 163.86200 305.26600 -20.59900 1.000 94.13163  ? 205 PRO F CB  1 
ATOM   1068 C CG  . PRO A 1 170 ? 164.30900 304.95300 -19.18300 1.000 96.14843  ? 205 PRO F CG  1 
ATOM   1069 C CD  . PRO A 1 170 ? 165.23700 306.06000 -18.78700 1.000 94.33863  ? 205 PRO F CD  1 
ATOM   1070 N N   . ILE A 1 171 ? 164.60900 308.33300 -21.81600 1.000 96.38217  ? 206 ILE F N   1 
ATOM   1071 C CA  . ILE A 1 171 ? 164.17600 309.42100 -22.68500 1.000 95.83130  ? 206 ILE F CA  1 
ATOM   1072 C C   . ILE A 1 171 ? 165.26900 309.99000 -23.59400 1.000 100.72606 ? 206 ILE F C   1 
ATOM   1073 O O   . ILE A 1 171 ? 164.96200 310.44700 -24.70000 1.000 105.07838 ? 206 ILE F O   1 
ATOM   1074 C CB  . ILE A 1 171 ? 163.60200 310.55400 -21.81100 1.000 92.32127  ? 206 ILE F CB  1 
ATOM   1075 C CG1 . ILE A 1 171 ? 162.37300 310.10300 -21.01300 1.000 88.53919  ? 206 ILE F CG1 1 
ATOM   1076 C CG2 . ILE A 1 171 ? 163.30700 311.81100 -22.66100 1.000 85.74337  ? 206 ILE F CG2 1 
ATOM   1077 C CD1 . ILE A 1 171 ? 161.21100 309.64200 -21.84400 1.000 92.86257  ? 206 ILE F CD1 1 
ATOM   1078 N N   . VAL A 1 172 ? 166.53000 309.99900 -23.17500 1.000 102.71144 ? 207 VAL F N   1 
ATOM   1079 C CA  . VAL A 1 172 ? 167.56600 310.60400 -24.01500 1.000 106.92558 ? 207 VAL F CA  1 
ATOM   1080 C C   . VAL A 1 172 ? 168.66400 309.60000 -24.33200 1.000 114.45507 ? 207 VAL F C   1 
ATOM   1081 O O   . VAL A 1 172 ? 169.30300 309.67000 -25.38900 1.000 117.17091 ? 207 VAL F O   1 
ATOM   1082 C CB  . VAL A 1 172 ? 168.18000 311.85600 -23.36000 1.000 109.24755 ? 207 VAL F CB  1 
ATOM   1083 C CG1 . VAL A 1 172 ? 167.26300 313.05400 -23.53300 1.000 107.41020 ? 207 VAL F CG1 1 
ATOM   1084 C CG2 . VAL A 1 172 ? 168.45900 311.58600 -21.89100 1.000 106.71664 ? 207 VAL F CG2 1 
ATOM   1085 N N   . ASN A 1 173 ? 168.90600 308.67300 -23.40500 1.000 115.05277 ? 208 ASN F N   1 
ATOM   1086 C CA  . ASN A 1 173 ? 169.99600 307.71200 -23.53300 1.000 120.55983 ? 208 ASN F CA  1 
ATOM   1087 C C   . ASN A 1 173 ? 169.76500 306.69600 -24.64100 1.000 121.80678 ? 208 ASN F C   1 
ATOM   1088 O O   . ASN A 1 173 ? 170.73500 306.09000 -25.11200 1.000 125.17466 ? 208 ASN F O   1 
ATOM   1089 C CB  . ASN A 1 173 ? 170.20600 306.98100 -22.21000 1.000 118.62045 ? 208 ASN F CB  1 
ATOM   1090 C CG  . ASN A 1 173 ? 171.51000 306.19500 -22.17000 1.000 124.67220 ? 208 ASN F CG  1 
ATOM   1091 O OD1 . ASN A 1 173 ? 172.47300 306.52500 -22.86200 1.000 128.29887 ? 208 ASN F OD1 1 
ATOM   1092 N ND2 . ASN A 1 173 ? 171.54300 305.14200 -21.34600 1.000 121.18950 ? 208 ASN F ND2 1 
ATOM   1093 N N   . LYS A 1 174 ? 168.52200 306.49300 -25.07900 1.000 120.11287 ? 209 LYS F N   1 
ATOM   1094 C CA  . LYS A 1 174 ? 168.32100 305.54200 -26.16300 1.000 121.37395 ? 209 LYS F CA  1 
ATOM   1095 C C   . LYS A 1 174 ? 168.81800 306.18300 -27.46700 1.000 120.90562 ? 209 LYS F C   1 
ATOM   1096 O O   . LYS A 1 174 ? 169.32500 307.30800 -27.48100 1.000 121.09026 ? 209 LYS F O   1 
ATOM   1097 C CB  . LYS A 1 174 ? 166.84900 305.08300 -26.11600 1.000 117.49877 ? 209 LYS F CB  1 
ATOM   1098 C CG  . LYS A 1 174 ? 166.34700 303.92000 -26.97900 1.000 113.42861 ? 209 LYS F CG  1 
ATOM   1099 C CD  . LYS A 1 174 ? 164.84500 303.66200 -26.71100 1.000 105.38840 ? 209 LYS F CD  1 
ATOM   1100 C CE  . LYS A 1 174 ? 163.98100 304.93900 -26.61400 1.000 103.17619 ? 209 LYS F CE  1 
ATOM   1101 N NZ  . LYS A 1 174 ? 163.38400 305.51200 -27.84600 1.000 101.51509 ? 209 LYS F NZ  1 
ATOM   1102 N N   . GLN A 1 175 ? 168.65100 305.48100 -28.58600 1.000 120.76599 ? 210 GLN F N   1 
ATOM   1103 C CA  . GLN A 1 175 ? 169.03700 306.03900 -29.88500 1.000 120.99255 ? 210 GLN F CA  1 
ATOM   1104 C C   . GLN A 1 175 ? 168.09500 307.15400 -30.33800 1.000 125.32103 ? 210 GLN F C   1 
ATOM   1105 O O   . GLN A 1 175 ? 168.54500 308.24200 -30.72700 1.000 125.58095 ? 210 GLN F O   1 
ATOM   1106 C CB  . GLN A 1 175 ? 169.26300 304.94100 -30.91700 1.000 121.73527 ? 210 GLN F CB  1 
ATOM   1107 C CG  . GLN A 1 175 ? 170.67800 304.38800 -30.65000 1.000 119.46003 ? 210 GLN F CG  1 
ATOM   1108 C CD  . GLN A 1 175 ? 171.28200 303.56200 -31.76100 1.000 120.46476 ? 210 GLN F CD  1 
ATOM   1109 O OE1 . GLN A 1 175 ? 170.58400 303.03800 -32.62900 1.000 121.31749 ? 210 GLN F OE1 1 
ATOM   1110 N NE2 . GLN A 1 175 ? 172.60900 303.45400 -31.74500 1.000 117.33483 ? 210 GLN F NE2 1 
ATOM   1111 N N   . SER A 1 176 ? 166.78900 306.90000 -30.30900 1.000 123.44566 ? 211 SER F N   1 
ATOM   1112 C CA  . SER A 1 176 ? 165.79800 307.92700 -30.59100 1.000 119.10705 ? 211 SER F CA  1 
ATOM   1113 C C   . SER A 1 176 ? 165.05800 308.19200 -29.28400 1.000 114.56329 ? 211 SER F C   1 
ATOM   1114 O O   . SER A 1 176 ? 164.80900 307.27300 -28.49000 1.000 110.82891 ? 211 SER F O   1 
ATOM   1115 C CB  . SER A 1 176 ? 164.82100 307.46900 -31.68200 1.000 117.90193 ? 211 SER F CB  1 
ATOM   1116 O OG  . SER A 1 176 ? 165.50600 306.94000 -32.80600 1.000 113.65650 ? 211 SER F OG  1 
ATOM   1117 N N   . CYS A 1 177 ? 164.72000 309.46000 -29.06100 1.000 114.77465 ? 212 CYS F N   1 
ATOM   1118 C CA  . CYS A 1 177 ? 164.14200 309.84500 -27.78100 1.000 111.98303 ? 212 CYS F CA  1 
ATOM   1119 C C   . CYS A 1 177 ? 162.77900 309.22300 -27.52400 1.000 104.02488 ? 212 CYS F C   1 
ATOM   1120 O O   . CYS A 1 177 ? 161.91200 309.20400 -28.40200 1.000 103.58620 ? 212 CYS F O   1 
ATOM   1121 C CB  . CYS A 1 177 ? 163.98500 311.37000 -27.72200 1.000 109.28533 ? 212 CYS F CB  1 
ATOM   1122 S SG  . CYS A 1 177 ? 165.33400 312.39200 -28.40500 1.000 126.05601 ? 212 CYS F SG  1 
ATOM   1123 N N   . SER A 1 178 ? 162.59400 308.70200 -26.31400 1.000 97.05735  ? 213 SER F N   1 
ATOM   1124 C CA  . SER A 1 178 ? 161.26000 308.33400 -25.89900 1.000 91.81018  ? 213 SER F CA  1 
ATOM   1125 C C   . SER A 1 178 ? 160.48900 309.58600 -25.45700 1.000 89.24788  ? 213 SER F C   1 
ATOM   1126 O O   . SER A 1 178 ? 161.07100 310.60000 -25.07600 1.000 88.29219  ? 213 SER F O   1 
ATOM   1127 C CB  . SER A 1 178 ? 161.33800 307.32300 -24.75400 1.000 89.00381  ? 213 SER F CB  1 
ATOM   1128 O OG  . SER A 1 178 ? 160.05100 306.88100 -24.38400 1.000 93.66753  ? 213 SER F OG  1 
ATOM   1129 N N   . ILE A 1 179 ? 159.16600 309.50400 -25.53600 1.000 86.65617  ? 214 ILE F N   1 
ATOM   1130 C CA  . ILE A 1 179 ? 158.27900 310.62400 -25.21300 1.000 79.69010  ? 214 ILE F CA  1 
ATOM   1131 C C   . ILE A 1 179 ? 157.89800 310.53000 -23.73200 1.000 79.69090  ? 214 ILE F C   1 
ATOM   1132 O O   . ILE A 1 179 ? 157.25800 309.54800 -23.33000 1.000 80.54741  ? 214 ILE F O   1 
ATOM   1133 C CB  . ILE A 1 179 ? 157.05700 310.72100 -26.12700 1.000 82.99721  ? 214 ILE F CB  1 
ATOM   1134 C CG1 . ILE A 1 179 ? 157.54100 310.89300 -27.56200 1.000 81.10004  ? 214 ILE F CG1 1 
ATOM   1135 C CG2 . ILE A 1 179 ? 156.30200 311.96900 -25.81700 1.000 76.50336  ? 214 ILE F CG2 1 
ATOM   1136 C CD1 . ILE A 1 179 ? 158.58300 311.96700 -27.70000 1.000 78.19861  ? 214 ILE F CD1 1 
ATOM   1137 N N   . PRO A 1 180 ? 158.28600 311.49000 -22.90100 1.000 76.92635  ? 215 PRO F N   1 
ATOM   1138 C CA  . PRO A 1 180 ? 157.85500 311.46900 -21.49800 1.000 72.34685  ? 215 PRO F CA  1 
ATOM   1139 C C   . PRO A 1 180 ? 156.47800 312.07600 -21.28300 1.000 67.84642  ? 215 PRO F C   1 
ATOM   1140 O O   . PRO A 1 180 ? 156.01700 312.93200 -22.03800 1.000 70.92997  ? 215 PRO F O   1 
ATOM   1141 C CB  . PRO A 1 180 ? 158.91000 312.34300 -20.80800 1.000 71.52281  ? 215 PRO F CB  1 
ATOM   1142 C CG  . PRO A 1 180 ? 159.25100 313.36000 -21.86100 1.000 74.80946  ? 215 PRO F CG  1 
ATOM   1143 C CD  . PRO A 1 180 ? 159.12700 312.65900 -23.20300 1.000 74.51247  ? 215 PRO F CD  1 
ATOM   1144 N N   . ASN A 1 181 ? 155.79600 311.57400 -20.25900 1.000 62.62341  ? 216 ASN F N   1 
ATOM   1145 C CA  . ASN A 1 181 ? 154.48300 312.10200 -19.92700 1.000 65.20023  ? 216 ASN F CA  1 
ATOM   1146 C C   . ASN A 1 181 ? 154.69000 313.45800 -19.24600 1.000 66.55667  ? 216 ASN F C   1 
ATOM   1147 O O   . ASN A 1 181 ? 155.76600 313.75200 -18.71900 1.000 62.57524  ? 216 ASN F O   1 
ATOM   1148 C CB  . ASN A 1 181 ? 153.73700 311.19300 -18.96100 1.000 71.66432  ? 216 ASN F CB  1 
ATOM   1149 C CG  . ASN A 1 181 ? 154.59500 310.77900 -17.77900 1.000 71.87837  ? 216 ASN F CG  1 
ATOM   1150 O OD1 . ASN A 1 181 ? 155.75600 310.39100 -17.93100 1.000 69.92073  ? 216 ASN F OD1 1 
ATOM   1151 N ND2 . ASN A 1 181 ? 154.02800 310.89500 -16.58100 1.000 73.50855  ? 216 ASN F ND2 1 
ATOM   1152 N N   . ILE A 1 182 ? 153.65100 314.29600 -19.27500 1.000 63.22735  ? 217 ILE F N   1 
ATOM   1153 C CA  . ILE A 1 182 ? 153.74400 315.64100 -18.70000 1.000 67.28295  ? 217 ILE F CA  1 
ATOM   1154 C C   . ILE A 1 182 ? 153.94300 315.69700 -17.17900 1.000 66.16372  ? 217 ILE F C   1 
ATOM   1155 O O   . ILE A 1 182 ? 154.59100 316.63600 -16.66200 1.000 69.77958  ? 217 ILE F O   1 
ATOM   1156 C CB  . ILE A 1 182 ? 152.44900 316.37900 -19.07700 1.000 56.51210  ? 217 ILE F CB  1 
ATOM   1157 C CG1 . ILE A 1 182 ? 152.64500 317.88700 -18.99700 1.000 57.29443  ? 217 ILE F CG1 1 
ATOM   1158 C CG2 . ILE A 1 182 ? 151.30700 315.91800 -18.16700 1.000 61.35884  ? 217 ILE F CG2 1 
ATOM   1159 C CD1 . ILE A 1 182 ? 153.70600 318.37800 -19.95800 1.000 60.40359  ? 217 ILE F CD1 1 
ATOM   1160 N N   . GLU A 1 183 ? 153.53300 314.65100 -16.46500 1.000 63.05056  ? 218 GLU F N   1 
ATOM   1161 C CA  . GLU A 1 183 ? 153.78700 314.59100 -15.03400 1.000 65.02483  ? 218 GLU F CA  1 
ATOM   1162 C C   . GLU A 1 183 ? 155.27600 314.52400 -14.74700 1.000 66.67437  ? 218 GLU F C   1 
ATOM   1163 O O   . GLU A 1 183 ? 155.74200 315.08200 -13.75600 1.000 67.74196  ? 218 GLU F O   1 
ATOM   1164 C CB  . GLU A 1 183 ? 153.04900 313.42100 -14.38400 1.000 64.52321  ? 218 GLU F CB  1 
ATOM   1165 C CG  . GLU A 1 183 ? 151.53200 313.57100 -14.37500 1.000 66.47397  ? 218 GLU F CG  1 
ATOM   1166 C CD  . GLU A 1 183 ? 150.86000 313.10700 -15.67900 1.000 68.83935  ? 218 GLU F CD  1 
ATOM   1167 O OE1 . GLU A 1 183 ? 151.56100 312.64800 -16.61500 1.000 67.09646  ? 218 GLU F OE1 1 
ATOM   1168 O OE2 . GLU A 1 183 ? 149.61800 313.19700 -15.74900 1.000 71.27260  ? 218 GLU F OE2 1 
ATOM   1169 N N   . THR A 1 184 ? 156.03000 313.83300 -15.59400 1.000 60.65918  ? 219 THR F N   1 
ATOM   1170 C CA  . THR A 1 184 ? 157.47200 313.75200 -15.41400 1.000 64.03789  ? 219 THR F CA  1 
ATOM   1171 C C   . THR A 1 184 ? 158.13800 315.10700 -15.62000 1.000 64.74879  ? 219 THR F C   1 
ATOM   1172 O O   . THR A 1 184 ? 159.07300 315.45800 -14.89700 1.000 65.23608  ? 219 THR F O   1 
ATOM   1173 C CB  . THR A 1 184 ? 158.03300 312.70700 -16.37300 1.000 60.24484  ? 219 THR F CB  1 
ATOM   1174 O OG1 . THR A 1 184 ? 157.47800 311.44100 -16.02300 1.000 62.11665  ? 219 THR F OG1 1 
ATOM   1175 C CG2 . THR A 1 184 ? 159.55300 312.63700 -16.31700 1.000 61.14500  ? 219 THR F CG2 1 
ATOM   1176 N N   . VAL A 1 185 ? 157.68900 315.88000 -16.59800 1.000 60.41109  ? 220 VAL F N   1 
ATOM   1177 C CA  . VAL A 1 185 ? 158.29100 317.19000 -16.79800 1.000 63.46744  ? 220 VAL F CA  1 
ATOM   1178 C C   . VAL A 1 185 ? 158.10200 318.04300 -15.55200 1.000 66.04810  ? 220 VAL F C   1 
ATOM   1179 O O   . VAL A 1 185 ? 159.05800 318.64800 -15.03200 1.000 67.95569  ? 220 VAL F O   1 
ATOM   1180 C CB  . VAL A 1 185 ? 157.68300 317.86100 -18.03800 1.000 60.96713  ? 220 VAL F CB  1 
ATOM   1181 C CG1 . VAL A 1 185 ? 158.23300 319.25900 -18.21500 1.000 59.75391  ? 220 VAL F CG1 1 
ATOM   1182 C CG2 . VAL A 1 185 ? 157.95700 317.00800 -19.24900 1.000 67.41122  ? 220 VAL F CG2 1 
ATOM   1183 N N   . ILE A 1 186 ? 156.91100 317.97200 -14.95900 1.000 61.91978  ? 221 ILE F N   1 
ATOM   1184 C CA  . ILE A 1 186 ? 156.67100 318.79900 -13.78500 1.000 62.87700  ? 221 ILE F CA  1 
ATOM   1185 C C   . ILE A 1 186 ? 157.42500 318.25100 -12.57300 1.000 67.64538  ? 221 ILE F C   1 
ATOM   1186 O O   . ILE A 1 186 ? 158.02500 319.01900 -11.80800 1.000 68.94640  ? 221 ILE F O   1 
ATOM   1187 C CB  . ILE A 1 186 ? 155.16100 318.88500 -13.54500 1.000 59.96745  ? 221 ILE F CB  1 
ATOM   1188 C CG1 . ILE A 1 186 ? 154.52200 319.66600 -14.70500 1.000 59.65440  ? 221 ILE F CG1 1 
ATOM   1189 C CG2 . ILE A 1 186 ? 154.89400 319.55900 -12.23200 1.000 57.37982  ? 221 ILE F CG2 1 
ATOM   1190 C CD1 . ILE A 1 186 ? 153.01300 319.81300 -14.60800 1.000 54.41818  ? 221 ILE F CD1 1 
ATOM   1191 N N   . GLU A 1 187 ? 157.44100 316.92300 -12.39300 1.000 65.58001  ? 222 GLU F N   1 
ATOM   1192 C CA  . GLU A 1 187 ? 158.14800 316.31700 -11.26700 1.000 69.06909  ? 222 GLU F CA  1 
ATOM   1193 C C   . GLU A 1 187 ? 159.63800 316.57100 -11.32800 1.000 68.69259  ? 222 GLU F C   1 
ATOM   1194 O O   . GLU A 1 187 ? 160.27500 316.82500 -10.29300 1.000 66.10916  ? 222 GLU F O   1 
ATOM   1195 C CB  . GLU A 1 187 ? 157.95200 314.79800 -11.30600 1.000 66.85882  ? 222 GLU F CB  1 
ATOM   1196 C CG  . GLU A 1 187 ? 158.21400 313.94400 -10.05500 1.000 74.10050  ? 222 GLU F CG  1 
ATOM   1197 C CD  . GLU A 1 187 ? 157.67800 314.48900 -8.75700  1.000 82.53593  ? 222 GLU F CD  1 
ATOM   1198 O OE1 . GLU A 1 187 ? 156.53100 314.13800 -8.38700  1.000 88.73026  ? 222 GLU F OE1 1 
ATOM   1199 O OE2 . GLU A 1 187 ? 158.42900 315.22500 -8.07900  1.000 81.53676  ? 222 GLU F OE2 1 
ATOM   1200 N N   . PHE A 1 188 ? 160.18800 316.65000 -12.52900 1.000 65.26689  ? 223 PHE F N   1 
ATOM   1201 C CA  . PHE A 1 188 ? 161.60800 316.89800 -12.59400 1.000 67.58479  ? 223 PHE F CA  1 
ATOM   1202 C C   . PHE A 1 188 ? 161.91700 318.35500 -12.33100 1.000 66.73632  ? 223 PHE F C   1 
ATOM   1203 O O   . PHE A 1 188 ? 162.92700 318.64300 -11.68600 1.000 63.28528  ? 223 PHE F O   1 
ATOM   1204 C CB  . PHE A 1 188 ? 162.15200 316.43900 -13.94100 1.000 63.82360  ? 223 PHE F CB  1 
ATOM   1205 C CG  . PHE A 1 188 ? 163.63400 316.56800 -14.06700 1.000 62.88405  ? 223 PHE F CG  1 
ATOM   1206 C CD1 . PHE A 1 188 ? 164.46900 316.09100 -13.07500 1.000 62.88491  ? 223 PHE F CD1 1 
ATOM   1207 C CD2 . PHE A 1 188 ? 164.19800 317.13600 -15.20200 1.000 63.74922  ? 223 PHE F CD2 1 
ATOM   1208 C CE1 . PHE A 1 188 ? 165.83800 316.20400 -13.19800 1.000 64.81857  ? 223 PHE F CE1 1 
ATOM   1209 C CE2 . PHE A 1 188 ? 165.56300 317.24900 -15.33100 1.000 60.52168  ? 223 PHE F CE2 1 
ATOM   1210 C CZ  . PHE A 1 188 ? 166.38300 316.77800 -14.33500 1.000 61.64340  ? 223 PHE F CZ  1 
ATOM   1211 N N   . GLN A 1 189 ? 161.03500 319.28100 -12.72300 1.000 57.46040  ? 224 GLN F N   1 
ATOM   1212 C CA  . GLN A 1 189 ? 161.32400 320.65900 -12.35100 1.000 64.46591  ? 224 GLN F CA  1 
ATOM   1213 C C   . GLN A 1 189 ? 161.21300 320.86800 -10.84000 1.000 67.04317  ? 224 GLN F C   1 
ATOM   1214 O O   . GLN A 1 189 ? 162.08000 321.53200 -10.24200 1.000 63.52727  ? 224 GLN F O   1 
ATOM   1215 C CB  . GLN A 1 189 ? 160.39000 321.59500 -13.10400 1.000 64.79181  ? 224 GLN F CB  1 
ATOM   1216 C CG  . GLN A 1 189 ? 160.68500 321.63300 -14.59700 1.000 74.06738  ? 224 GLN F CG  1 
ATOM   1217 C CD  . GLN A 1 189 ? 159.68200 322.45600 -15.39400 1.000 80.89631  ? 224 GLN F CD  1 
ATOM   1218 O OE1 . GLN A 1 189 ? 159.68500 322.43200 -16.63200 1.000 74.57316  ? 224 GLN F OE1 1 
ATOM   1219 N NE2 . GLN A 1 189 ? 158.78400 323.15300 -14.68400 1.000 76.72048  ? 224 GLN F NE2 1 
ATOM   1220 N N   . GLN A 1 190 ? 160.32200 320.11300 -10.19100 1.000 63.20926  ? 225 GLN F N   1 
ATOM   1221 C CA  . GLN A 1 190 ? 160.18700 320.22200 -8.74100  1.000 69.53559  ? 225 GLN F CA  1 
ATOM   1222 C C   . GLN A 1 190 ? 161.39100 319.64100 -8.01200  1.000 65.74717  ? 225 GLN F C   1 
ATOM   1223 O O   . GLN A 1 190 ? 161.92300 320.26600 -7.09200  1.000 67.77395  ? 225 GLN F O   1 
ATOM   1224 C CB  . GLN A 1 190 ? 158.91200 319.52500 -8.26400  1.000 66.65868  ? 225 GLN F CB  1 
ATOM   1225 C CG  . GLN A 1 190 ? 157.65400 320.10100 -8.84200  1.000 67.63307  ? 225 GLN F CG  1 
ATOM   1226 C CD  . GLN A 1 190 ? 157.41800 321.49200 -8.34200  1.000 76.01866  ? 225 GLN F CD  1 
ATOM   1227 O OE1 . GLN A 1 190 ? 157.51400 322.46200 -9.09800  1.000 78.63507  ? 225 GLN F OE1 1 
ATOM   1228 N NE2 . GLN A 1 190 ? 157.09700 321.60900 -7.06100  1.000 80.43533  ? 225 GLN F NE2 1 
ATOM   1229 N N   . LYS A 1 191 ? 161.86200 318.47300 -8.44000  1.000 68.92571  ? 226 LYS F N   1 
ATOM   1230 C CA  . LYS A 1 191 ? 162.99800 317.84600 -7.77600  1.000 65.63289  ? 226 LYS F CA  1 
ATOM   1231 C C   . LYS A 1 191 ? 164.29000 318.61000 -8.03800  1.000 66.79018  ? 226 LYS F C   1 
ATOM   1232 O O   . LYS A 1 191 ? 165.10600 318.78200 -7.12900  1.000 69.50917  ? 226 LYS F O   1 
ATOM   1233 C CB  . LYS A 1 191 ? 163.13500 316.39600 -8.24500  1.000 67.09076  ? 226 LYS F CB  1 
ATOM   1234 C CG  . LYS A 1 191 ? 162.15300 315.41300 -7.62400  1.000 72.86132  ? 226 LYS F CG  1 
ATOM   1235 C CD  . LYS A 1 191 ? 162.62500 313.95400 -7.77800  1.000 70.48808  ? 226 LYS F CD  1 
ATOM   1236 C CE  . LYS A 1 191 ? 162.80900 313.25700 -6.43200  1.000 74.44590  ? 226 LYS F CE  1 
ATOM   1237 N NZ  . LYS A 1 191 ? 161.51300 312.79200 -5.85100  1.000 70.30539  ? 226 LYS F NZ  1 
ATOM   1238 N N   . ASN A 1 192 ? 164.50100 319.07200 -9.26900  1.000 63.49501  ? 227 ASN F N   1 
ATOM   1239 C CA  . ASN A 1 192 ? 165.73700 319.75800 -9.61000  1.000 62.99890  ? 227 ASN F CA  1 
ATOM   1240 C C   . ASN A 1 192 ? 165.81500 321.14600 -8.96200  1.000 66.59897  ? 227 ASN F C   1 
ATOM   1241 O O   . ASN A 1 192 ? 166.92300 321.70300 -8.83400  1.000 58.61385  ? 227 ASN F O   1 
ATOM   1242 C CB  . ASN A 1 192 ? 165.82300 319.90700 -11.12400 1.000 60.63224  ? 227 ASN F CB  1 
ATOM   1243 C CG  . ASN A 1 192 ? 167.19400 320.31300 -11.59800 1.000 60.17972  ? 227 ASN F CG  1 
ATOM   1244 O OD1 . ASN A 1 192 ? 168.18800 319.93600 -10.98800 1.000 65.51398  ? 227 ASN F OD1 1 
ATOM   1245 N ND2 . ASN A 1 192 ? 167.26300 321.10300 -12.66500 1.000 55.37924  ? 227 ASN F ND2 1 
ATOM   1246 N N   . ASN A 1 193 ? 164.67700 321.68400 -8.49000  1.000 64.84306  ? 228 ASN F N   1 
ATOM   1247 C CA  . ASN A 1 193 ? 164.67900 323.05500 -7.98400  1.000 60.44925  ? 228 ASN F CA  1 
ATOM   1248 C C   . ASN A 1 193 ? 165.60300 323.22600 -6.77400  1.000 62.79193  ? 228 ASN F C   1 
ATOM   1249 O O   . ASN A 1 193 ? 166.38800 324.17600 -6.73200  1.000 61.02294  ? 228 ASN F O   1 
ATOM   1250 C CB  . ASN A 1 193 ? 163.25900 323.45000 -7.58600  1.000 58.64763  ? 228 ASN F CB  1 
ATOM   1251 C CG  . ASN A 1 193 ? 163.17300 324.86500 -7.07100  1.000 63.28521  ? 228 ASN F CG  1 
ATOM   1252 O OD1 . ASN A 1 193 ? 163.74300 325.77400 -7.65800  1.000 71.06250  ? 228 ASN F OD1 1 
ATOM   1253 N ND2 . ASN A 1 193 ? 162.50500 325.05100 -5.93800  1.000 58.80104  ? 228 ASN F ND2 1 
ATOM   1254 N N   . ARG A 1 194 ? 165.56500 322.30300 -5.81000  1.000 60.28050  ? 229 ARG F N   1 
ATOM   1255 C CA  . ARG A 1 194 ? 166.40300 322.47400 -4.63000  1.000 60.91900  ? 229 ARG F CA  1 
ATOM   1256 C C   . ARG A 1 194 ? 167.88200 322.45500 -4.97400  1.000 65.48485  ? 229 ARG F C   1 
ATOM   1257 O O   . ARG A 1 194 ? 168.65800 323.24500 -4.41900  1.000 64.73668  ? 229 ARG F O   1 
ATOM   1258 C CB  . ARG A 1 194 ? 166.09800 321.39200 -3.60000  1.000 60.45566  ? 229 ARG F CB  1 
ATOM   1259 C CG  . ARG A 1 194 ? 166.80500 321.60500 -2.26400  1.000 64.75748  ? 229 ARG F CG  1 
ATOM   1260 C CD  . ARG A 1 194 ? 166.40600 320.55000 -1.23500  1.000 66.57551  ? 229 ARG F CD  1 
ATOM   1261 N NE  . ARG A 1 194 ? 167.00900 320.80700 0.06700   1.000 71.08370  ? 229 ARG F NE  1 
ATOM   1262 C CZ  . ARG A 1 194 ? 166.83100 320.05900 1.14600   1.000 69.82318  ? 229 ARG F CZ  1 
ATOM   1263 N NH1 . ARG A 1 194 ? 166.06400 318.98700 1.12000   1.000 67.60634  ? 229 ARG F NH1 1 
ATOM   1264 N NH2 . ARG A 1 194 ? 167.44200 320.39700 2.28200   1.000 67.21041  ? 229 ARG F NH2 1 
ATOM   1265 N N   . LEU A 1 195 ? 168.27100 321.65700 -5.96500  1.000 61.36679  ? 230 LEU F N   1 
ATOM   1266 C CA  . LEU A 1 195 ? 169.65900 321.66200 -6.38700  1.000 58.70341  ? 230 LEU F CA  1 
ATOM   1267 C C   . LEU A 1 195 ? 170.02700 323.01400 -6.95900  1.000 62.44295  ? 230 LEU F C   1 
ATOM   1268 O O   . LEU A 1 195 ? 171.11400 323.54400 -6.68100  1.000 63.63361  ? 230 LEU F O   1 
ATOM   1269 C CB  . LEU A 1 195 ? 169.89000 320.58000 -7.43500  1.000 60.73840  ? 230 LEU F CB  1 
ATOM   1270 C CG  . LEU A 1 195 ? 171.29600 320.57700 -8.03000  1.000 59.18282  ? 230 LEU F CG  1 
ATOM   1271 C CD1 . LEU A 1 195 ? 172.28500 320.31000 -6.93900  1.000 52.36752  ? 230 LEU F CD1 1 
ATOM   1272 C CD2 . LEU A 1 195 ? 171.41800 319.55700 -9.15100  1.000 58.24725  ? 230 LEU F CD2 1 
ATOM   1273 N N   . LEU A 1 196 ? 169.14400 323.57900 -7.78400  1.000 61.89778  ? 231 LEU F N   1 
ATOM   1274 C CA  . LEU A 1 196 ? 169.47000 324.86800 -8.38800  1.000 62.53208  ? 231 LEU F CA  1 
ATOM   1275 C C   . LEU A 1 196 ? 169.55500 325.98200 -7.33900  1.000 62.93761  ? 231 LEU F C   1 
ATOM   1276 O O   . LEU A 1 196 ? 170.42000 326.86200 -7.43000  1.000 63.49540  ? 231 LEU F O   1 
ATOM   1277 C CB  . LEU A 1 196 ? 168.44700 325.21400 -9.46000  1.000 60.31376  ? 231 LEU F CB  1 
ATOM   1278 C CG  . LEU A 1 196 ? 168.22400 324.19000 -10.56800 1.000 64.28162  ? 231 LEU F CG  1 
ATOM   1279 C CD1 . LEU A 1 196 ? 167.26000 324.77600 -11.57700 1.000 57.66059  ? 231 LEU F CD1 1 
ATOM   1280 C CD2 . LEU A 1 196 ? 169.56700 323.94900 -11.25000 1.000 59.00725  ? 231 LEU F CD2 1 
ATOM   1281 N N   . GLU A 1 197 ? 168.67900 325.95400 -6.33100  1.000 59.11469  ? 232 GLU F N   1 
ATOM   1282 C CA  . GLU A 1 197 ? 168.70800 327.00200 -5.31600  1.000 64.08746  ? 232 GLU F CA  1 
ATOM   1283 C C   . GLU A 1 197 ? 169.91800 326.87100 -4.40300  1.000 66.88617  ? 232 GLU F C   1 
ATOM   1284 O O   . GLU A 1 197 ? 170.51500 327.88200 -4.00700  1.000 66.03247  ? 232 GLU F O   1 
ATOM   1285 C CB  . GLU A 1 197 ? 167.42400 327.01400 -4.50300  1.000 60.86498  ? 232 GLU F CB  1 
ATOM   1286 C CG  . GLU A 1 197 ? 166.23700 327.31300 -5.36500  1.000 70.72271  ? 232 GLU F CG  1 
ATOM   1287 C CD  . GLU A 1 197 ? 166.21900 328.77900 -5.75800  1.000 73.26484  ? 232 GLU F CD  1 
ATOM   1288 O OE1 . GLU A 1 197 ? 167.05400 329.54700 -5.22800  1.000 74.27474  ? 232 GLU F OE1 1 
ATOM   1289 O OE2 . GLU A 1 197 ? 165.38600 329.16300 -6.59900  1.000 76.68476  ? 232 GLU F OE2 1 
ATOM   1290 N N   . ILE A 1 198 ? 170.35700 325.64300 -4.14800  1.000 64.82727  ? 233 ILE F N   1 
ATOM   1291 C CA  . ILE A 1 198 ? 171.53400 325.46400 -3.32000  1.000 63.60313  ? 233 ILE F CA  1 
ATOM   1292 C C   . ILE A 1 198 ? 172.74800 325.96000 -4.07400  1.000 67.60720  ? 233 ILE F C   1 
ATOM   1293 O O   . ILE A 1 198 ? 173.60400 326.65900 -3.51200  1.000 65.65179  ? 233 ILE F O   1 
ATOM   1294 C CB  . ILE A 1 198 ? 171.66500 323.98600 -2.92900  1.000 59.57073  ? 233 ILE F CB  1 
ATOM   1295 C CG1 . ILE A 1 198 ? 170.55700 323.61700 -1.94100  1.000 63.66163  ? 233 ILE F CG1 1 
ATOM   1296 C CG2 . ILE A 1 198 ? 173.04600 323.68200 -2.42100  1.000 61.13559  ? 233 ILE F CG2 1 
ATOM   1297 C CD1 . ILE A 1 198 ? 170.52700 322.14500 -1.56300  1.000 64.53180  ? 233 ILE F CD1 1 
ATOM   1298 N N   . THR A 1 199 ? 172.81200 325.66200 -5.37200  1.000 62.68058  ? 234 THR F N   1 
ATOM   1299 C CA  . THR A 1 199 ? 173.90500 326.19100 -6.16200  1.000 65.39912  ? 234 THR F CA  1 
ATOM   1300 C C   . THR A 1 199 ? 173.86400 327.71300 -6.22800  1.000 64.71068  ? 234 THR F C   1 
ATOM   1301 O O   . THR A 1 199 ? 174.91100 328.35300 -6.16800  1.000 63.89164  ? 234 THR F O   1 
ATOM   1302 C CB  . THR A 1 199 ? 173.82700 325.60200 -7.58400  1.000 64.72691  ? 234 THR F CB  1 
ATOM   1303 O OG1 . THR A 1 199 ? 174.00600 324.18100 -7.53100  1.000 65.13870  ? 234 THR F OG1 1 
ATOM   1304 C CG2 . THR A 1 199 ? 174.87600 326.21800 -8.52700  1.000 62.02059  ? 234 THR F CG2 1 
ATOM   1305 N N   . ARG A 1 200 ? 172.66800 328.31300 -6.23000  1.000 65.33626  ? 235 ARG F N   1 
ATOM   1306 C CA  . ARG A 1 200 ? 172.56500 329.77500 -6.28100  1.000 65.18171  ? 235 ARG F CA  1 
ATOM   1307 C C   . ARG A 1 200 ? 173.12400 330.41900 -5.01100  1.000 65.25117  ? 235 ARG F C   1 
ATOM   1308 O O   . ARG A 1 200 ? 173.97100 331.33200 -5.08000  1.000 68.42683  ? 235 ARG F O   1 
ATOM   1309 C CB  . ARG A 1 200 ? 171.10800 330.17000 -6.51900  1.000 67.20987  ? 235 ARG F CB  1 
ATOM   1310 C CG  . ARG A 1 200 ? 170.87400 331.56000 -7.08600  1.000 65.78767  ? 235 ARG F CG  1 
ATOM   1311 C CD  . ARG A 1 200 ? 169.37300 331.80400 -7.35800  1.000 76.86973  ? 235 ARG F CD  1 
ATOM   1312 N NE  . ARG A 1 200 ? 168.73300 330.74500 -8.14600  1.000 78.40963  ? 235 ARG F NE  1 
ATOM   1313 C CZ  . ARG A 1 200 ? 168.80300 330.62000 -9.47000  1.000 79.71459  ? 235 ARG F CZ  1 
ATOM   1314 N NH1 . ARG A 1 200 ? 169.48300 331.48100 -10.21800 1.000 78.34830  ? 235 ARG F NH1 1 
ATOM   1315 N NH2 . ARG A 1 200 ? 168.19100 329.59400 -10.05700 1.000 73.26312  ? 235 ARG F NH2 1 
ATOM   1316 N N   . GLU A 1 201 ? 172.75700 329.86200 -3.84000  1.000 64.66691  ? 236 GLU F N   1 
ATOM   1317 C CA  . GLU A 1 201 ? 173.23900 330.42100 -2.57800  1.000 63.16526  ? 236 GLU F CA  1 
ATOM   1318 C C   . GLU A 1 201 ? 174.73200 330.20500 -2.44500  1.000 68.57216  ? 236 GLU F C   1 
ATOM   1319 O O   . GLU A 1 201 ? 175.45200 331.09700 -1.98500  1.000 73.17489  ? 236 GLU F O   1 
ATOM   1320 C CB  . GLU A 1 201 ? 172.51900 329.82300 -1.36300  1.000 59.94068  ? 236 GLU F CB  1 
ATOM   1321 C CG  . GLU A 1 201 ? 171.03200 329.96500 -1.31400  1.000 53.52438  ? 236 GLU F CG  1 
ATOM   1322 C CD  . GLU A 1 201 ? 170.41800 329.39500 -0.02000  1.000 65.90368  ? 236 GLU F CD  1 
ATOM   1323 O OE1 . GLU A 1 201 ? 171.14500 329.15200 0.97400   1.000 72.81982  ? 236 GLU F OE1 1 
ATOM   1324 O OE2 . GLU A 1 201 ? 169.17900 329.28300 0.05100   1.000 64.22508  ? 236 GLU F OE2 1 
ATOM   1325 N N   . PHE A 1 202 ? 175.21200 329.02600 -2.82600  1.000 71.97551  ? 237 PHE F N   1 
ATOM   1326 C CA  . PHE A 1 202 ? 176.63000 328.73300 -2.71600  1.000 68.36402  ? 237 PHE F CA  1 
ATOM   1327 C C   . PHE A 1 202 ? 177.43700 329.57200 -3.70800  1.000 68.01693  ? 237 PHE F C   1 
ATOM   1328 O O   . PHE A 1 202 ? 178.59200 329.91800 -3.43100  1.000 70.19859  ? 237 PHE F O   1 
ATOM   1329 C CB  . PHE A 1 202 ? 176.86500 327.23100 -2.90000  1.000 67.48526  ? 237 PHE F CB  1 
ATOM   1330 C CG  . PHE A 1 202 ? 176.70700 326.44200 -1.62400  1.000 67.87073  ? 237 PHE F CG  1 
ATOM   1331 C CD1 . PHE A 1 202 ? 176.98000 327.02500 -0.39900  1.000 64.89354  ? 237 PHE F CD1 1 
ATOM   1332 C CD2 . PHE A 1 202 ? 176.26100 325.12500 -1.64600  1.000 69.52290  ? 237 PHE F CD2 1 
ATOM   1333 C CE1 . PHE A 1 202 ? 176.82900 326.30400 0.78300   1.000 65.49077  ? 237 PHE F CE1 1 
ATOM   1334 C CE2 . PHE A 1 202 ? 176.10500 324.39200 -0.46500  1.000 65.08166  ? 237 PHE F CE2 1 
ATOM   1335 C CZ  . PHE A 1 202 ? 176.39200 324.97800 0.75000   1.000 67.15778  ? 237 PHE F CZ  1 
ATOM   1336 N N   . SER A 1 203 ? 176.83800 329.97300 -4.83100  1.000 65.14217  ? 238 SER F N   1 
ATOM   1337 C CA  . SER A 1 203 ? 177.59900 330.75100 -5.80700  1.000 67.11084  ? 238 SER F CA  1 
ATOM   1338 C C   . SER A 1 203 ? 177.79500 332.18700 -5.33200  1.000 71.10792  ? 238 SER F C   1 
ATOM   1339 O O   . SER A 1 203 ? 178.87600 332.75500 -5.51100  1.000 73.22573  ? 238 SER F O   1 
ATOM   1340 C CB  . SER A 1 203 ? 176.87900 330.76100 -7.15500  1.000 68.21602  ? 238 SER F CB  1 
ATOM   1341 O OG  . SER A 1 203 ? 176.74500 329.46300 -7.69600  1.000 77.65314  ? 238 SER F OG  1 
ATOM   1342 N N   . VAL A 1 204 ? 176.75000 332.82500 -4.80500  1.000 69.45313  ? 239 VAL F N   1 
ATOM   1343 C CA  . VAL A 1 204 ? 176.93900 334.22400 -4.39800  1.000 71.36638  ? 239 VAL F CA  1 
ATOM   1344 C C   . VAL A 1 204 ? 177.73600 334.38300 -3.09700  1.000 71.54527  ? 239 VAL F C   1 
ATOM   1345 O O   . VAL A 1 204 ? 178.25200 335.47900 -2.82900  1.000 70.34763  ? 239 VAL F O   1 
ATOM   1346 C CB  . VAL A 1 204 ? 175.60800 334.97800 -4.30900  1.000 65.67208  ? 239 VAL F CB  1 
ATOM   1347 C CG1 . VAL A 1 204 ? 174.92200 334.92600 -5.65500  1.000 74.53184  ? 239 VAL F CG1 1 
ATOM   1348 C CG2 . VAL A 1 204 ? 174.73000 334.34600 -3.26100  1.000 67.13184  ? 239 VAL F CG2 1 
ATOM   1349 N N   . ASN A 1 205 ? 177.86100 333.32600 -2.28700  1.000 66.31890  ? 240 ASN F N   1 
ATOM   1350 C CA  . ASN A 1 205 ? 178.50800 333.38500 -0.98200  1.000 63.93965  ? 240 ASN F CA  1 
ATOM   1351 C C   . ASN A 1 205 ? 179.79800 332.59100 -0.90000  1.000 62.53592  ? 240 ASN F C   1 
ATOM   1352 O O   . ASN A 1 205 ? 180.20300 332.21100 0.20100   1.000 62.26253  ? 240 ASN F O   1 
ATOM   1353 C CB  . ASN A 1 205 ? 177.56000 332.86000 0.09500   1.000 63.08493  ? 240 ASN F CB  1 
ATOM   1354 C CG  . ASN A 1 205 ? 176.32600 333.70300 0.27400   1.000 69.17061  ? 240 ASN F CG  1 
ATOM   1355 O OD1 . ASN A 1 205 ? 175.21900 333.17500 0.32600   1.000 73.80988  ? 240 ASN F OD1 1 
ATOM   1356 N ND2 . ASN A 1 205 ? 176.51500 334.99200 0.53600   1.000 69.57771  ? 240 ASN F ND2 1 
ATOM   1357 N N   . ALA A 1 206 ? 180.39200 332.23000 -2.02900  1.000 62.71573  ? 241 ALA F N   1 
ATOM   1358 C CA  . ALA A 1 206 ? 181.70100 331.57500 -2.01400  1.000 68.57766  ? 241 ALA F CA  1 
ATOM   1359 C C   . ALA A 1 206 ? 181.71200 330.31400 -1.14400  1.000 63.54466  ? 241 ALA F C   1 
ATOM   1360 O O   . ALA A 1 206 ? 182.70100 330.03000 -0.47400  1.000 66.64624  ? 241 ALA F O   1 
ATOM   1361 C CB  . ALA A 1 206 ? 182.79200 332.54000 -1.55500  1.000 71.84130  ? 241 ALA F CB  1 
ATOM   1362 N N   . GLY A 1 207 ? 180.64700 329.50400 -1.20900  1.000 68.65621  ? 242 GLY F N   1 
ATOM   1363 C CA  . GLY A 1 207 ? 180.61000 328.23100 -0.49300  1.000 63.46485  ? 242 GLY F CA  1 
ATOM   1364 C C   . GLY A 1 207 ? 180.26900 328.24300 0.99000   1.000 60.69172  ? 242 GLY F C   1 
ATOM   1365 O O   . GLY A 1 207 ? 180.25200 327.16700 1.60400   1.000 62.48076  ? 242 GLY F O   1 
ATOM   1366 N N   . VAL A 1 208 ? 180.13700 329.40100 1.62500   1.000 64.25622  ? 243 VAL F N   1 
ATOM   1367 C CA  . VAL A 1 208 ? 179.81200 329.50000 3.05200   1.000 61.24158  ? 243 VAL F CA  1 
ATOM   1368 C C   . VAL A 1 208 ? 178.58400 330.37300 3.28100   1.000 61.88159  ? 243 VAL F C   1 
ATOM   1369 O O   . VAL A 1 208 ? 178.63100 331.57900 3.02100   1.000 67.73594  ? 243 VAL F O   1 
ATOM   1370 C CB  . VAL A 1 208 ? 180.98600 330.03000 3.87700   1.000 57.33714  ? 243 VAL F CB  1 
ATOM   1371 C CG1 . VAL A 1 208 ? 180.62200 329.98800 5.35500   1.000 59.14338  ? 243 VAL F CG1 1 
ATOM   1372 C CG2 . VAL A 1 208 ? 182.21800 329.18600 3.60800   1.000 55.21372  ? 243 VAL F CG2 1 
ATOM   1373 N N   . THR A 1 209 ? 177.47200 329.77200 3.68100   1.000 54.16958  ? 244 THR F N   1 
ATOM   1374 C CA  . THR A 1 209 ? 176.24700 330.52500 3.89100   1.000 59.77355  ? 244 THR F CA  1 
ATOM   1375 C C   . THR A 1 209 ? 175.90300 330.48400 5.37500   1.000 60.26707  ? 244 THR F C   1 
ATOM   1376 O O   . THR A 1 209 ? 176.26500 329.52700 6.07300   1.000 58.03965  ? 244 THR F O   1 
ATOM   1377 C CB  . THR A 1 209 ? 175.03500 329.98200 3.09700   1.000 60.65206  ? 244 THR F CB  1 
ATOM   1378 O OG1 . THR A 1 209 ? 174.61500 328.69800 3.60700   1.000 56.05311  ? 244 THR F OG1 1 
ATOM   1379 C CG2 . THR A 1 209 ? 175.35900 329.85800 1.59900   1.000 63.91080  ? 244 THR F CG2 1 
ATOM   1380 N N   . THR A 1 210 ? 175.37900 331.60300 5.88600   1.000 60.97309  ? 245 THR F N   1 
ATOM   1381 C CA  . THR A 1 210 ? 174.84800 331.71300 7.24100   1.000 58.86525  ? 245 THR F CA  1 
ATOM   1382 C C   . THR A 1 210 ? 173.93000 332.92400 7.14300   1.000 54.57950  ? 245 THR F C   1 
ATOM   1383 O O   . THR A 1 210 ? 174.35700 333.96300 6.64100   1.000 64.09897  ? 245 THR F O   1 
ATOM   1384 C CB  . THR A 1 210 ? 175.94400 331.90500 8.29900   1.000 58.61441  ? 245 THR F CB  1 
ATOM   1385 O OG1 . THR A 1 210 ? 175.34500 332.15200 9.57700   1.000 55.95105  ? 245 THR F OG1 1 
ATOM   1386 C CG2 . THR A 1 210 ? 176.76800 333.10500 7.96000   1.000 56.24805  ? 245 THR F CG2 1 
ATOM   1387 N N   . PRO A 1 211 ? 172.68800 332.86300 7.62300   1.000 59.14398  ? 246 PRO F N   1 
ATOM   1388 C CA  . PRO A 1 211 ? 172.13300 331.69300 8.28800   1.000 55.87022  ? 246 PRO F CA  1 
ATOM   1389 C C   . PRO A 1 211 ? 171.95900 330.56000 7.27500   1.000 61.09460  ? 246 PRO F C   1 
ATOM   1390 O O   . PRO A 1 211 ? 172.20500 330.71100 6.07200   1.000 59.43912  ? 246 PRO F O   1 
ATOM   1391 C CB  . PRO A 1 211 ? 170.75500 332.17400 8.76100   1.000 52.22596  ? 246 PRO F CB  1 
ATOM   1392 C CG  . PRO A 1 211 ? 170.80100 333.64600 8.67900   1.000 61.08372  ? 246 PRO F CG  1 
ATOM   1393 C CD  . PRO A 1 211 ? 171.70300 333.94600 7.53500   1.000 55.85821  ? 246 PRO F CD  1 
ATOM   1394 N N   . VAL A 1 212 ? 171.64100 329.39100 7.80800   1.000 55.18869  ? 247 VAL F N   1 
ATOM   1395 C CA  . VAL A 1 212 ? 171.41800 328.19500 7.01100   1.000 57.76620  ? 247 VAL F CA  1 
ATOM   1396 C C   . VAL A 1 212 ? 169.96800 328.21300 6.52400   1.000 57.53439  ? 247 VAL F C   1 
ATOM   1397 O O   . VAL A 1 212 ? 169.03500 328.16700 7.32900   1.000 58.30351  ? 247 VAL F O   1 
ATOM   1398 C CB  . VAL A 1 212 ? 171.73300 326.94000 7.82400   1.000 55.76954  ? 247 VAL F CB  1 
ATOM   1399 C CG1 . VAL A 1 212 ? 171.43300 325.67200 7.02000   1.000 53.72716  ? 247 VAL F CG1 1 
ATOM   1400 C CG2 . VAL A 1 212 ? 173.17800 327.01900 8.31600   1.000 51.81966  ? 247 VAL F CG2 1 
ATOM   1401 N N   . SER A 1 213 ? 169.76800 328.31500 5.20900   1.000 67.89410  ? 248 SER F N   1 
ATOM   1402 C CA  . SER A 1 213 ? 168.40500 328.41000 4.68700   1.000 64.51582  ? 248 SER F CA  1 
ATOM   1403 C C   . SER A 1 213 ? 167.67600 327.06200 4.71400   1.000 67.86512  ? 248 SER F C   1 
ATOM   1404 O O   . SER A 1 213 ? 168.25500 325.99100 4.95400   1.000 64.67777  ? 248 SER F O   1 
ATOM   1405 C CB  . SER A 1 213 ? 168.41200 328.84900 3.23500   1.000 63.28936  ? 248 SER F CB  1 
ATOM   1406 O OG  . SER A 1 213 ? 169.08400 327.86100 2.47500   1.000 63.97257  ? 248 SER F OG  1 
ATOM   1407 N N   . THR A 1 214 ? 166.36100 327.13700 4.48400   1.000 66.75365  ? 249 THR F N   1 
ATOM   1408 C CA  . THR A 1 214 ? 165.56300 325.92200 4.37300   1.000 68.53961  ? 249 THR F CA  1 
ATOM   1409 C C   . THR A 1 214 ? 165.93000 325.13300 3.11400   1.000 65.31378  ? 249 THR F C   1 
ATOM   1410 O O   . THR A 1 214 ? 165.63100 323.93700 3.04700   1.000 65.07534  ? 249 THR F O   1 
ATOM   1411 C CB  . THR A 1 214 ? 164.05800 326.23800 4.48500   1.000 65.84254  ? 249 THR F CB  1 
ATOM   1412 O OG1 . THR A 1 214 ? 163.66700 327.18600 3.48700   1.000 71.69685  ? 249 THR F OG1 1 
ATOM   1413 C CG2 . THR A 1 214 ? 163.69200 326.74200 5.87400   1.000 60.77204  ? 249 THR F CG2 1 
ATOM   1414 N N   . TYR A 1 215 ? 166.55900 325.77300 2.11800   1.000 61.59431  ? 250 TYR F N   1 
ATOM   1415 C CA  . TYR A 1 215 ? 167.08100 325.01900 0.97800   1.000 62.25873  ? 250 TYR F CA  1 
ATOM   1416 C C   . TYR A 1 215 ? 168.27000 324.16300 1.39100   1.000 67.28084  ? 250 TYR F C   1 
ATOM   1417 O O   . TYR A 1 215 ? 168.39900 323.01100 0.95500   1.000 64.54721  ? 250 TYR F O   1 
ATOM   1418 C CB  . TYR A 1 215 ? 167.50800 325.95700 -0.14700  1.000 63.77104  ? 250 TYR F CB  1 
ATOM   1419 C CG  . TYR A 1 215 ? 166.41500 326.66300 -0.89000  1.000 67.08594  ? 250 TYR F CG  1 
ATOM   1420 C CD1 . TYR A 1 215 ? 165.19600 326.04000 -1.13400  1.000 70.71221  ? 250 TYR F CD1 1 
ATOM   1421 C CD2 . TYR A 1 215 ? 166.57700 327.97600 -1.30100  1.000 67.87457  ? 250 TYR F CD2 1 
ATOM   1422 C CE1 . TYR A 1 215 ? 164.18400 326.69500 -1.82700  1.000 72.76176  ? 250 TYR F CE1 1 
ATOM   1423 C CE2 . TYR A 1 215 ? 165.57500 328.64500 -1.97500  1.000 73.58422  ? 250 TYR F CE2 1 
ATOM   1424 C CZ  . TYR A 1 215 ? 164.38000 328.00700 -2.23500  1.000 75.61734  ? 250 TYR F CZ  1 
ATOM   1425 O OH  . TYR A 1 215 ? 163.39600 328.68400 -2.92000  1.000 75.02434  ? 250 TYR F OH  1 
ATOM   1426 N N   . MET A 1 216 ? 169.15900 324.72200 2.21700   1.000 65.35598  ? 251 MET F N   1 
ATOM   1427 C CA  . MET A 1 216 ? 170.27200 323.95300 2.74800   1.000 62.03174  ? 251 MET F CA  1 
ATOM   1428 C C   . MET A 1 216 ? 169.76200 322.88600 3.69700   1.000 64.48938  ? 251 MET F C   1 
ATOM   1429 O O   . MET A 1 216 ? 170.26400 321.75500 3.71000   1.000 61.56448  ? 251 MET F O   1 
ATOM   1430 C CB  . MET A 1 216 ? 171.22600 324.88800 3.48200   1.000 65.87848  ? 251 MET F CB  1 
ATOM   1431 C CG  . MET A 1 216 ? 171.88200 325.86500 2.58000   1.000 60.75124  ? 251 MET F CG  1 
ATOM   1432 S SD  . MET A 1 216 ? 173.10600 325.00200 1.64100   1.000 62.45521  ? 251 MET F SD  1 
ATOM   1433 C CE  . MET A 1 216 ? 173.58300 326.29700 0.52200   1.000 62.97295  ? 251 MET F CE  1 
ATOM   1434 N N   . LEU A 1 217 ? 168.77000 323.23800 4.51600   1.000 63.41089  ? 252 LEU F N   1 
ATOM   1435 C CA  . LEU A 1 217 ? 168.26100 322.29200 5.49100   1.000 62.53792  ? 252 LEU F CA  1 
ATOM   1436 C C   . LEU A 1 217 ? 166.81900 322.67800 5.82200   1.000 65.98286  ? 252 LEU F C   1 
ATOM   1437 O O   . LEU A 1 217 ? 166.58000 323.75700 6.36600   1.000 70.15585  ? 252 LEU F O   1 
ATOM   1438 C CB  . LEU A 1 217 ? 169.16200 322.29000 6.72300   1.000 65.21764  ? 252 LEU F CB  1 
ATOM   1439 C CG  . LEU A 1 217 ? 169.07900 321.07700 7.63500   1.000 66.24293  ? 252 LEU F CG  1 
ATOM   1440 C CD1 . LEU A 1 217 ? 169.53400 319.91700 6.80600   1.000 60.65546  ? 252 LEU F CD1 1 
ATOM   1441 C CD2 . LEU A 1 217 ? 169.98000 321.19900 8.82400   1.000 65.83825  ? 252 LEU F CD2 1 
ATOM   1442 N N   . THR A 1 218 ? 165.85800 321.83800 5.46000   1.000 70.69672  ? 253 THR F N   1 
ATOM   1443 C CA  . THR A 1 218 ? 164.46800 322.15200 5.75700   1.000 69.62384  ? 253 THR F CA  1 
ATOM   1444 C C   . THR A 1 218 ? 164.22200 322.09800 7.26600   1.000 68.74580  ? 253 THR F C   1 
ATOM   1445 O O   . THR A 1 218 ? 164.89800 321.38200 8.01700   1.000 66.90804  ? 253 THR F O   1 
ATOM   1446 C CB  . THR A 1 218 ? 163.50900 321.21300 5.01900   1.000 68.06140  ? 253 THR F CB  1 
ATOM   1447 O OG1 . THR A 1 218 ? 163.32900 320.01400 5.78200   1.000 71.42997  ? 253 THR F OG1 1 
ATOM   1448 C CG2 . THR A 1 218 ? 164.04300 320.87500 3.64400   1.000 67.86433  ? 253 THR F CG2 1 
ATOM   1449 N N   . ASN A 1 219 ? 163.19500 322.82500 7.70400   1.000 64.77206  ? 254 ASN F N   1 
ATOM   1450 C CA  . ASN A 1 219 ? 162.85200 322.77900 9.11600   1.000 66.68532  ? 254 ASN F CA  1 
ATOM   1451 C C   . ASN A 1 219 ? 162.59000 321.36200 9.58000   1.000 72.36656  ? 254 ASN F C   1 
ATOM   1452 O O   . ASN A 1 219 ? 162.99300 320.98300 10.68900  1.000 70.17226  ? 254 ASN F O   1 
ATOM   1453 C CB  . ASN A 1 219 ? 161.63500 323.64700 9.40200   1.000 66.92883  ? 254 ASN F CB  1 
ATOM   1454 C CG  . ASN A 1 219 ? 161.92000 325.12000 9.26600   1.000 72.93019  ? 254 ASN F CG  1 
ATOM   1455 O OD1 . ASN A 1 219 ? 162.92100 325.53300 8.67900   1.000 76.50210  ? 254 ASN F OD1 1 
ATOM   1456 N ND2 . ASN A 1 219 ? 161.03600 325.93100 9.82900   1.000 75.94058  ? 254 ASN F ND2 1 
ATOM   1457 N N   . SER A 1 220 ? 161.96200 320.54600 8.73500   1.000 72.13295  ? 255 SER F N   1 
ATOM   1458 C CA  . SER A 1 220 ? 161.76900 319.15500 9.11500   1.000 69.02357  ? 255 SER F CA  1 
ATOM   1459 C C   . SER A 1 220 ? 163.09900 318.43700 9.25800   1.000 67.60316  ? 255 SER F C   1 
ATOM   1460 O O   . SER A 1 220 ? 163.32000 317.70800 10.23800  1.000 70.39813  ? 255 SER F O   1 
ATOM   1461 C CB  . SER A 1 220 ? 160.89300 318.44800 8.08300   1.000 70.40276  ? 255 SER F CB  1 
ATOM   1462 O OG  . SER A 1 220 ? 159.53000 318.55900 8.43900   1.000 79.41653  ? 255 SER F OG  1 
ATOM   1463 N N   . GLU A 1 221 ? 164.02600 318.68300 8.33400   1.000 63.71690  ? 256 GLU F N   1 
ATOM   1464 C CA  . GLU A 1 221 ? 165.31500 318.02400 8.44300   1.000 66.20846  ? 256 GLU F CA  1 
ATOM   1465 C C   . GLU A 1 221 ? 166.13700 318.56900 9.59500   1.000 70.08749  ? 256 GLU F C   1 
ATOM   1466 O O   . GLU A 1 221 ? 166.82600 317.79800 10.26500  1.000 68.01035  ? 256 GLU F O   1 
ATOM   1467 C CB  . GLU A 1 221 ? 166.08100 318.20400 7.14800   1.000 69.47678  ? 256 GLU F CB  1 
ATOM   1468 C CG  . GLU A 1 221 ? 165.29800 317.77700 5.93200   1.000 72.93297  ? 256 GLU F CG  1 
ATOM   1469 C CD  . GLU A 1 221 ? 165.96300 318.22600 4.65900   1.000 71.76947  ? 256 GLU F CD  1 
ATOM   1470 O OE1 . GLU A 1 221 ? 166.90700 319.04300 4.73900   1.000 67.97977  ? 256 GLU F OE1 1 
ATOM   1471 O OE2 . GLU A 1 221 ? 165.55500 317.74300 3.58200   1.000 77.08121  ? 256 GLU F OE2 1 
ATOM   1472 N N   . LEU A 1 222 ? 166.01700 319.86600 9.90100   1.000 70.51545  ? 257 LEU F N   1 
ATOM   1473 C CA  . LEU A 1 222 ? 166.80000 320.41600 10.99800  1.000 60.76389  ? 257 LEU F CA  1 
ATOM   1474 C C   . LEU A 1 222 ? 166.29300 319.87400 12.32300  1.000 66.65768  ? 257 LEU F C   1 
ATOM   1475 O O   . LEU A 1 222 ? 167.08900 319.46800 13.17300  1.000 64.75243  ? 257 LEU F O   1 
ATOM   1476 C CB  . LEU A 1 222 ? 166.77100 321.94200 10.99000  1.000 68.34545  ? 257 LEU F CB  1 
ATOM   1477 C CG  . LEU A 1 222 ? 167.52600 322.66400 12.13100  1.000 69.11902  ? 257 LEU F CG  1 
ATOM   1478 C CD1 . LEU A 1 222 ? 169.02900 322.33400 12.18900  1.000 52.48366  ? 257 LEU F CD1 1 
ATOM   1479 C CD2 . LEU A 1 222 ? 167.31500 324.16000 12.02300  1.000 62.89188  ? 257 LEU F CD2 1 
ATOM   1480 N N   . LEU A 1 223 ? 164.96800 319.85000 12.51000  1.000 64.65859  ? 258 LEU F N   1 
ATOM   1481 C CA  . LEU A 1 223 ? 164.40700 319.33200 13.75300  1.000 66.39113  ? 258 LEU F CA  1 
ATOM   1482 C C   . LEU A 1 223 ? 164.72600 317.85800 13.92800  1.000 70.40492  ? 258 LEU F C   1 
ATOM   1483 O O   . LEU A 1 223 ? 164.98800 317.40100 15.05500  1.000 65.72978  ? 258 LEU F O   1 
ATOM   1484 C CB  . LEU A 1 223 ? 162.89600 319.56200 13.79900  1.000 65.23790  ? 258 LEU F CB  1 
ATOM   1485 C CG  . LEU A 1 223 ? 162.40900 320.99800 13.94700  1.000 67.01954  ? 258 LEU F CG  1 
ATOM   1486 C CD1 . LEU A 1 223 ? 160.89500 321.07500 13.85800  1.000 64.51205  ? 258 LEU F CD1 1 
ATOM   1487 C CD2 . LEU A 1 223 ? 162.84300 321.50400 15.31200  1.000 56.45782  ? 258 LEU F CD2 1 
ATOM   1488 N N   . SER A 1 224 ? 164.67100 317.08700 12.83400  1.000 70.46283  ? 259 SER F N   1 
ATOM   1489 C CA  . SER A 1 224 ? 165.07000 315.68700 12.91600  1.000 71.86227  ? 259 SER F CA  1 
ATOM   1490 C C   . SER A 1 224 ? 166.56100 315.54600 13.22200  1.000 67.69185  ? 259 SER F C   1 
ATOM   1491 O O   . SER A 1 224 ? 166.97400 314.60500 13.90600  1.000 68.51369  ? 259 SER F O   1 
ATOM   1492 C CB  . SER A 1 224 ? 164.69900 314.97000 11.61200  1.000 73.48019  ? 259 SER F CB  1 
ATOM   1493 O OG  . SER A 1 224 ? 165.63600 313.94700 11.29700  1.000 78.51316  ? 259 SER F OG  1 
ATOM   1494 N N   . LEU A 1 225 ? 167.38400 316.47000 12.74000  1.000 69.17031  ? 260 LEU F N   1 
ATOM   1495 C CA  . LEU A 1 225 ? 168.80400 316.39800 13.04700  1.000 66.14483  ? 260 LEU F CA  1 
ATOM   1496 C C   . LEU A 1 225 ? 169.06300 316.77600 14.49800  1.000 71.11804  ? 260 LEU F C   1 
ATOM   1497 O O   . LEU A 1 225 ? 169.89300 316.15800 15.17600  1.000 71.07080  ? 260 LEU F O   1 
ATOM   1498 C CB  . LEU A 1 225 ? 169.56200 317.32300 12.11500  1.000 62.68086  ? 260 LEU F CB  1 
ATOM   1499 C CG  . LEU A 1 225 ? 171.06400 317.24600 12.23800  1.000 63.39727  ? 260 LEU F CG  1 
ATOM   1500 C CD1 . LEU A 1 225 ? 171.47600 315.80200 12.20400  1.000 73.40823  ? 260 LEU F CD1 1 
ATOM   1501 C CD2 . LEU A 1 225 ? 171.65200 317.98900 11.06900  1.000 62.21419  ? 260 LEU F CD2 1 
ATOM   1502 N N   . ILE A 1 226 ? 168.29200 317.72600 15.01400  1.000 66.97299  ? 261 ILE F N   1 
ATOM   1503 C CA  . ILE A 1 226 ? 168.43800 318.11000 16.40600  1.000 68.02042  ? 261 ILE F CA  1 
ATOM   1504 C C   . ILE A 1 226 ? 168.04500 316.93700 17.27800  1.000 70.55383  ? 261 ILE F C   1 
ATOM   1505 O O   . ILE A 1 226 ? 168.71600 316.61600 18.26600  1.000 71.15573  ? 261 ILE F O   1 
ATOM   1506 C CB  . ILE A 1 226 ? 167.54700 319.33500 16.67500  1.000 62.39317  ? 261 ILE F CB  1 
ATOM   1507 C CG1 . ILE A 1 226 ? 168.06100 320.56100 15.92300  1.000 57.48364  ? 261 ILE F CG1 1 
ATOM   1508 C CG2 . ILE A 1 226 ? 167.33100 319.55500 18.15600  1.000 57.33245  ? 261 ILE F CG2 1 
ATOM   1509 C CD1 . ILE A 1 226 ? 167.42000 321.81500 16.38200  1.000 55.78521  ? 261 ILE F CD1 1 
ATOM   1510 N N   . ASN A 1 227 ? 166.95500 316.26300 16.90500  1.000 70.42897  ? 262 ASN F N   1 
ATOM   1511 C CA  . ASN A 1 227 ? 166.45100 315.16900 17.71800  1.000 73.65596  ? 262 ASN F CA  1 
ATOM   1512 C C   . ASN A 1 227 ? 167.42800 314.00100 17.73800  1.000 74.27781  ? 262 ASN F C   1 
ATOM   1513 O O   . ASN A 1 227 ? 167.44500 313.21200 18.69100  1.000 70.90005  ? 262 ASN F O   1 
ATOM   1514 C CB  . ASN A 1 227 ? 165.09300 314.71400 17.19600  1.000 70.85165  ? 262 ASN F CB  1 
ATOM   1515 C CG  . ASN A 1 227 ? 164.47100 313.66900 18.07800  1.000 81.97619  ? 262 ASN F CG  1 
ATOM   1516 O OD1 . ASN A 1 227 ? 164.50600 313.78100 19.30700  1.000 88.82715  ? 262 ASN F OD1 1 
ATOM   1517 N ND2 . ASN A 1 227 ? 163.91800 312.62800 17.46600  1.000 78.82597  ? 262 ASN F ND2 1 
ATOM   1518 N N   . ASP A 1 228 ? 168.21800 313.86300 16.67600  1.000 74.01532  ? 263 ASP F N   1 
ATOM   1519 C CA  . ASP A 1 228 ? 169.12200 312.74300 16.51400  1.000 72.11329  ? 263 ASP F CA  1 
ATOM   1520 C C   . ASP A 1 228 ? 170.54300 313.04900 16.98800  1.000 76.21201  ? 263 ASP F C   1 
ATOM   1521 O O   . ASP A 1 228 ? 171.45800 312.27000 16.70500  1.000 83.48553  ? 263 ASP F O   1 
ATOM   1522 C CB  . ASP A 1 228 ? 169.13300 312.38100 15.03200  1.000 74.01651  ? 263 ASP F CB  1 
ATOM   1523 C CG  . ASP A 1 228 ? 168.02500 311.41800 14.66900  1.000 82.59615  ? 263 ASP F CG  1 
ATOM   1524 O OD1 . ASP A 1 228 ? 167.39900 310.86000 15.60000  1.000 81.94605  ? 263 ASP F OD1 1 
ATOM   1525 O OD2 . ASP A 1 228 ? 167.72900 311.28600 13.45700  1.000 82.22240  ? 263 ASP F OD2 1 
ATOM   1526 N N   . MET A 1 229 ? 170.76200 314.18300 17.67300  1.000 73.85402  ? 264 MET F N   1 
ATOM   1527 C CA  . MET A 1 229 ? 172.05600 314.68900 18.12200  1.000 75.46419  ? 264 MET F CA  1 
ATOM   1528 C C   . MET A 1 229 ? 172.44900 314.08900 19.46800  1.000 74.29623  ? 264 MET F C   1 
ATOM   1529 O O   . MET A 1 229 ? 171.58300 313.80500 20.30100  1.000 75.13936  ? 264 MET F O   1 
ATOM   1530 C CB  . MET A 1 229 ? 172.03000 316.21300 18.19000  1.000 74.72727  ? 264 MET F CB  1 
ATOM   1531 C CG  . MET A 1 229 ? 172.17600 316.85300 16.80700  1.000 73.35086  ? 264 MET F CG  1 
ATOM   1532 S SD  . MET A 1 229 ? 172.28500 318.65400 16.82600  1.000 75.05437  ? 264 MET F SD  1 
ATOM   1533 C CE  . MET A 1 229 ? 173.73600 318.99000 17.83600  1.000 64.58045  ? 264 MET F CE  1 
ATOM   1534 N N   . PRO A 1 230 ? 173.76100 313.92100 19.71900  1.000 74.42031  ? 265 PRO F N   1 
ATOM   1535 C CA  . PRO A 1 230 ? 174.24800 313.43000 21.02800  1.000 74.60383  ? 265 PRO F CA  1 
ATOM   1536 C C   . PRO A 1 230 ? 174.23900 314.51200 22.10200  1.000 70.53677  ? 265 PRO F C   1 
ATOM   1537 O O   . PRO A 1 230 ? 175.27000 314.88200 22.66000  1.000 70.58604  ? 265 PRO F O   1 
ATOM   1538 C CB  . PRO A 1 230 ? 175.67000 312.96700 20.69000  1.000 74.92177  ? 265 PRO F CB  1 
ATOM   1539 C CG  . PRO A 1 230 ? 176.10300 313.87500 19.58200  1.000 73.53197  ? 265 PRO F CG  1 
ATOM   1540 C CD  . PRO A 1 230 ? 174.85800 314.11700 18.75300  1.000 75.74796  ? 265 PRO F CD  1 
ATOM   1541 N N   . ILE A 1 231 ? 173.05400 315.05600 22.36800  1.000 70.31136  ? 266 ILE F N   1 
ATOM   1542 C CA  . ILE A 1 231 ? 172.86300 316.09000 23.37100  1.000 70.16860  ? 266 ILE F CA  1 
ATOM   1543 C C   . ILE A 1 231 ? 171.71300 315.70800 24.29700  1.000 68.07787  ? 266 ILE F C   1 
ATOM   1544 O O   . ILE A 1 231 ? 170.93100 314.80300 24.01200  1.000 64.91332  ? 266 ILE F O   1 
ATOM   1545 C CB  . ILE A 1 231 ? 172.60200 317.46300 22.71400  1.000 71.27442  ? 266 ILE F CB  1 
ATOM   1546 C CG1 . ILE A 1 231 ? 171.40400 317.38900 21.76200  1.000 69.56644  ? 266 ILE F CG1 1 
ATOM   1547 C CG2 . ILE A 1 231 ? 173.82000 317.87800 21.88700  1.000 67.94929  ? 266 ILE F CG2 1 
ATOM   1548 C CD1 . ILE A 1 231 ? 170.41000 318.52900 21.92400  1.000 69.22648  ? 266 ILE F CD1 1 
ATOM   1549 N N   . THR A 1 232 ? 171.62100 316.42400 25.41800  1.000 69.25499  ? 267 THR F N   1 
ATOM   1550 C CA  . THR A 1 232 ? 170.60200 316.16300 26.42800  1.000 71.05413  ? 267 THR F CA  1 
ATOM   1551 C C   . THR A 1 232 ? 169.22100 316.53800 25.89000  1.000 72.09008  ? 267 THR F C   1 
ATOM   1552 O O   . THR A 1 232 ? 169.08600 317.26700 24.90600  1.000 72.97641  ? 267 THR F O   1 
ATOM   1553 C CB  . THR A 1 232 ? 170.89000 316.92600 27.72300  1.000 72.39524  ? 267 THR F CB  1 
ATOM   1554 O OG1 . THR A 1 232 ? 169.75500 316.82700 28.59600  1.000 80.53579  ? 267 THR F OG1 1 
ATOM   1555 C CG2 . THR A 1 232 ? 171.15200 318.36900 27.44000  1.000 71.39986  ? 267 THR F CG2 1 
ATOM   1556 N N   . ASN A 1 233 ? 168.17900 316.02500 26.54500  1.000 73.08149  ? 268 ASN F N   1 
ATOM   1557 C CA  . ASN A 1 233 ? 166.82600 316.38400 26.13400  1.000 71.88054  ? 268 ASN F CA  1 
ATOM   1558 C C   . ASN A 1 233 ? 166.48900 317.85000 26.35800  1.000 71.89949  ? 268 ASN F C   1 
ATOM   1559 O O   . ASN A 1 233 ? 165.74800 318.42600 25.55500  1.000 72.68766  ? 268 ASN F O   1 
ATOM   1560 C CB  . ASN A 1 233 ? 165.79300 315.52800 26.86600  1.000 75.75319  ? 268 ASN F CB  1 
ATOM   1561 C CG  . ASN A 1 233 ? 165.52700 314.23100 26.17000  1.000 78.49862  ? 268 ASN F CG  1 
ATOM   1562 O OD1 . ASN A 1 233 ? 166.26200 313.26000 26.33600  1.000 85.43393  ? 268 ASN F OD1 1 
ATOM   1563 N ND2 . ASN A 1 233 ? 164.47100 314.20600 25.36100  1.000 78.42169  ? 268 ASN F ND2 1 
ATOM   1564 N N   . ASP A 1 234 ? 167.03600 318.49200 27.39200  1.000 74.50097  ? 269 ASP F N   1 
ATOM   1565 C CA  . ASP A 1 234 ? 166.78200 319.92400 27.50500  1.000 74.02175  ? 269 ASP F CA  1 
ATOM   1566 C C   . ASP A 1 234 ? 167.46200 320.70900 26.39600  1.000 69.89648  ? 269 ASP F C   1 
ATOM   1567 O O   . ASP A 1 234 ? 166.90100 321.70600 25.92900  1.000 66.60509  ? 269 ASP F O   1 
ATOM   1568 C CB  . ASP A 1 234 ? 167.16200 320.44900 28.88800  1.000 79.28384  ? 269 ASP F CB  1 
ATOM   1569 C CG  . ASP A 1 234 ? 166.40500 319.74800 30.00500  1.000 86.51725  ? 269 ASP F CG  1 
ATOM   1570 O OD1 . ASP A 1 234 ? 165.21500 319.41500 29.79300  1.000 80.84144  ? 269 ASP F OD1 1 
ATOM   1571 O OD2 . ASP A 1 234 ? 166.97900 319.58400 31.10800  1.000 94.27934  ? 269 ASP F OD2 1 
ATOM   1572 N N   . GLN A 1 235 ? 168.52600 320.17100 25.82000  1.000 67.63349  ? 270 GLN F N   1 
ATOM   1573 C CA  . GLN A 1 235 ? 169.17200 320.90200 24.75400  1.000 63.58237  ? 270 GLN F CA  1 
ATOM   1574 C C   . GLN A 1 235 ? 168.41000 320.66800 23.46000  1.000 62.59942  ? 270 GLN F C   1 
ATOM   1575 O O   . GLN A 1 235 ? 168.34800 321.56800 22.61300  1.000 59.61092  ? 270 GLN F O   1 
ATOM   1576 C CB  . GLN A 1 235 ? 170.61700 320.43500 24.61300  1.000 64.71419  ? 270 GLN F CB  1 
ATOM   1577 C CG  . GLN A 1 235 ? 171.51100 320.79400 25.78700  1.000 65.24249  ? 270 GLN F CG  1 
ATOM   1578 C CD  . GLN A 1 235 ? 172.40700 321.95300 25.43200  1.000 67.22240  ? 270 GLN F CD  1 
ATOM   1579 O OE1 . GLN A 1 235 ? 172.02700 322.81200 24.63600  1.000 68.11775  ? 270 GLN F OE1 1 
ATOM   1580 N NE2 . GLN A 1 235 ? 173.61100 321.96900 25.97800  1.000 67.83227  ? 270 GLN F NE2 1 
ATOM   1581 N N   . LYS A 1 236 ? 167.78800 319.49300 23.30700  1.000 59.64502  ? 271 LYS F N   1 
ATOM   1582 C CA  . LYS A 1 236 ? 166.96100 319.28500 22.13300  1.000 62.48791  ? 271 LYS F CA  1 
ATOM   1583 C C   . LYS A 1 236 ? 165.69800 320.13800 22.20400  1.000 59.66399  ? 271 LYS F C   1 
ATOM   1584 O O   . LYS A 1 236 ? 165.30100 320.75500 21.21000  1.000 59.71864  ? 271 LYS F O   1 
ATOM   1585 C CB  . LYS A 1 236 ? 166.58500 317.80300 22.00700  1.000 62.51566  ? 271 LYS F CB  1 
ATOM   1586 C CG  . LYS A 1 236 ? 167.75300 316.86600 21.76700  1.000 66.53990  ? 271 LYS F CG  1 
ATOM   1587 C CD  . LYS A 1 236 ? 167.32100 315.38900 21.67200  1.000 70.17726  ? 271 LYS F CD  1 
ATOM   1588 C CE  . LYS A 1 236 ? 168.54900 314.49500 21.46000  1.000 72.78409  ? 271 LYS F CE  1 
ATOM   1589 N NZ  . LYS A 1 236 ? 168.27800 313.03800 21.36500  1.000 71.08707  ? 271 LYS F NZ  1 
ATOM   1590 N N   . LYS A 1 237 ? 165.09900 320.26000 23.38900  1.000 61.57136  ? 272 LYS F N   1 
ATOM   1591 C CA  . LYS A 1 237 ? 163.93900 321.13600 23.51300  1.000 65.12762  ? 272 LYS F CA  1 
ATOM   1592 C C   . LYS A 1 237 ? 164.31600 322.59300 23.28400  1.000 63.05532  ? 272 LYS F C   1 
ATOM   1593 O O   . LYS A 1 237 ? 163.58800 323.34200 22.60800  1.000 60.12516  ? 272 LYS F O   1 
ATOM   1594 C CB  . LYS A 1 237 ? 163.33700 320.95800 24.91200  1.000 66.57066  ? 272 LYS F CB  1 
ATOM   1595 C CG  . LYS A 1 237 ? 161.86900 321.34900 25.10400  1.000 79.54675  ? 272 LYS F CG  1 
ATOM   1596 C CD  . LYS A 1 237 ? 160.92500 320.83000 23.99700  1.000 82.42407  ? 272 LYS F CD  1 
ATOM   1597 C CE  . LYS A 1 237 ? 159.47800 321.24800 24.29400  1.000 76.56561  ? 272 LYS F CE  1 
ATOM   1598 N NZ  . LYS A 1 237 ? 158.63200 321.39800 23.07700  1.000 82.07788  ? 272 LYS F NZ  1 
ATOM   1599 N N   . LEU A 1 238 ? 165.53300 322.95100 23.67000  1.000 57.92248  ? 273 LEU F N   1 
ATOM   1600 C CA  . LEU A 1 238 ? 165.96600 324.32500 23.51500  1.000 56.49076  ? 273 LEU F CA  1 
ATOM   1601 C C   . LEU A 1 238 ? 166.21300 324.64400 22.04900  1.000 51.28708  ? 273 LEU F C   1 
ATOM   1602 O O   . LEU A 1 238 ? 165.67700 325.62000 21.52200  1.000 49.49676  ? 273 LEU F O   1 
ATOM   1603 C CB  . LEU A 1 238 ? 167.23400 324.53900 24.34500  1.000 55.21487  ? 273 LEU F CB  1 
ATOM   1604 C CG  . LEU A 1 238 ? 167.82200 325.94500 24.44300  1.000 56.95038  ? 273 LEU F CG  1 
ATOM   1605 C CD1 . LEU A 1 238 ? 166.88600 326.95100 25.13700  1.000 59.77709  ? 273 LEU F CD1 1 
ATOM   1606 C CD2 . LEU A 1 238 ? 169.21100 325.92700 25.04800  1.000 61.16972  ? 273 LEU F CD2 1 
ATOM   1607 N N   . MET A 1 239 ? 166.96300 323.78600 21.35500  1.000 51.54737  ? 274 MET F N   1 
ATOM   1608 C CA  . MET A 1 239 ? 167.25200 324.07400 19.95500  1.000 54.07065  ? 274 MET F CA  1 
ATOM   1609 C C   . MET A 1 239 ? 166.01300 323.94400 19.08200  1.000 52.60873  ? 274 MET F C   1 
ATOM   1610 O O   . MET A 1 239 ? 165.87600 324.69500 18.10900  1.000 49.59359  ? 274 MET F O   1 
ATOM   1611 C CB  . MET A 1 239 ? 168.35400 323.13400 19.44000  1.000 49.70927  ? 274 MET F CB  1 
ATOM   1612 C CG  . MET A 1 239 ? 169.67200 323.23500 20.24000  1.000 50.47133  ? 274 MET F CG  1 
ATOM   1613 S SD  . MET A 1 239 ? 170.96900 322.10900 19.66100  1.000 54.36636  ? 274 MET F SD  1 
ATOM   1614 C CE  . MET A 1 239 ? 171.29000 322.73400 18.00300  1.000 51.00843  ? 274 MET F CE  1 
ATOM   1615 N N   . SER A 1 240 ? 165.07400 323.05100 19.44000  1.000 51.07309  ? 275 SER F N   1 
ATOM   1616 C CA  . SER A 1 240 ? 163.86400 322.85700 18.64400  1.000 49.52361  ? 275 SER F CA  1 
ATOM   1617 C C   . SER A 1 240 ? 162.87200 323.98200 18.83600  1.000 55.32468  ? 275 SER F C   1 
ATOM   1618 O O   . SER A 1 240 ? 162.15200 324.32900 17.89600  1.000 58.59932  ? 275 SER F O   1 
ATOM   1619 C CB  . SER A 1 240 ? 163.18000 321.54500 19.01500  1.000 55.33925  ? 275 SER F CB  1 
ATOM   1620 O OG  . SER A 1 240 ? 164.04100 320.44500 18.78400  1.000 55.54105  ? 275 SER F OG  1 
ATOM   1621 N N   . ASN A 1 241 ? 162.88500 324.62200 20.00500  1.000 53.81061  ? 276 ASN F N   1 
ATOM   1622 C CA  . ASN A 1 241 ? 162.00200 325.75000 20.24500  1.000 53.21070  ? 276 ASN F CA  1 
ATOM   1623 C C   . ASN A 1 241 ? 162.58600 327.06600 19.76200  1.000 54.95107  ? 276 ASN F C   1 
ATOM   1624 O O   . ASN A 1 241 ? 161.91300 328.09600 19.85700  1.000 59.27803  ? 276 ASN F O   1 
ATOM   1625 C CB  . ASN A 1 241 ? 161.61900 325.81900 21.72100  1.000 57.41405  ? 276 ASN F CB  1 
ATOM   1626 C CG  . ASN A 1 241 ? 160.76000 324.63500 22.14600  1.000 64.04847  ? 276 ASN F CG  1 
ATOM   1627 O OD1 . ASN A 1 241 ? 160.98000 324.03900 23.19700  1.000 73.41681  ? 276 ASN F OD1 1 
ATOM   1628 N ND2 . ASN A 1 241 ? 159.77000 324.30000 21.33300  1.000 58.77631  ? 276 ASN F ND2 1 
ATOM   1629 N N   . ASN A 1 242 ? 163.84800 327.08400 19.35700  1.000 51.99252  ? 277 ASN F N   1 
ATOM   1630 C CA  . ASN A 1 242 ? 164.47000 328.29200 18.83200  1.000 51.39314  ? 277 ASN F CA  1 
ATOM   1631 C C   . ASN A 1 242 ? 165.19500 327.98500 17.54200  1.000 47.42649  ? 277 ASN F C   1 
ATOM   1632 O O   . ASN A 1 242 ? 166.33300 328.41400 17.34100  1.000 47.73584  ? 277 ASN F O   1 
ATOM   1633 C CB  . ASN A 1 242 ? 165.44100 328.86400 19.85500  1.000 47.23413  ? 277 ASN F CB  1 
ATOM   1634 C CG  . ASN A 1 242 ? 164.79800 329.14000 21.16200  1.000 49.23552  ? 277 ASN F CG  1 
ATOM   1635 O OD1 . ASN A 1 242 ? 164.24000 330.21800 21.35200  1.000 55.11779  ? 277 ASN F OD1 1 
ATOM   1636 N ND2 . ASN A 1 242 ? 164.83600 328.17300 22.07800  1.000 48.16569  ? 277 ASN F ND2 1 
ATOM   1637 N N   . VAL A 1 243 ? 164.49900 327.36200 16.58100  1.000 48.93224  ? 278 VAL F N   1 
ATOM   1638 C CA  . VAL A 1 243 ? 165.18500 326.96500 15.34700  1.000 48.58532  ? 278 VAL F CA  1 
ATOM   1639 C C   . VAL A 1 243 ? 165.61700 328.17100 14.53900  1.000 47.34989  ? 278 VAL F C   1 
ATOM   1640 O O   . VAL A 1 243 ? 166.62700 328.11300 13.84100  1.000 46.40117  ? 278 VAL F O   1 
ATOM   1641 C CB  . VAL A 1 243 ? 164.34900 326.00400 14.46000  1.000 51.70011  ? 278 VAL F CB  1 
ATOM   1642 C CG1 . VAL A 1 243 ? 164.12800 324.67200 15.14200  1.000 53.20347  ? 278 VAL F CG1 1 
ATOM   1643 C CG2 . VAL A 1 243 ? 163.04700 326.62700 14.03800  1.000 47.98179  ? 278 VAL F CG2 1 
ATOM   1644 N N   . GLN A 1 244 ? 164.87800 329.27100 14.58500  1.000 50.69873  ? 279 GLN F N   1 
ATOM   1645 C CA  . GLN A 1 244 ? 165.32900 330.40700 13.79000  1.000 51.81047  ? 279 GLN F CA  1 
ATOM   1646 C C   . GLN A 1 244 ? 166.62800 330.98400 14.35800  1.000 51.17701  ? 279 GLN F C   1 
ATOM   1647 O O   . GLN A 1 244 ? 167.53400 331.36500 13.59700  1.000 49.75385  ? 279 GLN F O   1 
ATOM   1648 C CB  . GLN A 1 244 ? 164.23000 331.46500 13.72100  1.000 59.24653  ? 279 GLN F CB  1 
ATOM   1649 C CG  . GLN A 1 244 ? 163.83300 331.98700 15.09500  1.000 68.75513  ? 279 GLN F CG  1 
ATOM   1650 C CD  . GLN A 1 244 ? 162.51500 331.41000 15.60000  1.000 77.73114  ? 279 GLN F CD  1 
ATOM   1651 O OE1 . GLN A 1 244 ? 162.48900 330.42100 16.35400  1.000 73.73929  ? 279 GLN F OE1 1 
ATOM   1652 N NE2 . GLN A 1 244 ? 161.40900 332.04200 15.20200  1.000 79.06709  ? 279 GLN F NE2 1 
ATOM   1653 N N   . ILE A 1 245 ? 166.76500 331.02400 15.68900  1.000 48.91997  ? 280 ILE F N   1 
ATOM   1654 C CA  . ILE A 1 245 ? 168.04100 331.45900 16.25200  1.000 43.98822  ? 280 ILE F CA  1 
ATOM   1655 C C   . ILE A 1 245 ? 169.14100 330.44000 15.96400  1.000 43.61241  ? 280 ILE F C   1 
ATOM   1656 O O   . ILE A 1 245 ? 170.25000 330.81200 15.57100  1.000 45.99491  ? 280 ILE F O   1 
ATOM   1657 C CB  . ILE A 1 245 ? 167.89900 331.71700 17.75700  1.000 48.82206  ? 280 ILE F CB  1 
ATOM   1658 C CG1 . ILE A 1 245 ? 166.96700 332.90900 17.98200  1.000 52.22683  ? 280 ILE F CG1 1 
ATOM   1659 C CG2 . ILE A 1 245 ? 169.29100 332.00200 18.34000  1.000 44.40377  ? 280 ILE F CG2 1 
ATOM   1660 C CD1 . ILE A 1 245 ? 166.80400 333.28800 19.41100  1.000 55.84007  ? 280 ILE F CD1 1 
ATOM   1661 N N   . VAL A 1 246 ? 168.81700 329.14100 16.00600  1.000 44.86064  ? 281 VAL F N   1 
ATOM   1662 C CA  . VAL A 1 246 ? 169.80800 328.11900 15.66800  1.000 39.27111  ? 281 VAL F CA  1 
ATOM   1663 C C   . VAL A 1 246 ? 170.26500 328.27800 14.22500  1.000 42.56568  ? 281 VAL F C   1 
ATOM   1664 O O   . VAL A 1 246 ? 171.46500 328.16800 13.92400  1.000 41.79697  ? 281 VAL F O   1 
ATOM   1665 C CB  . VAL A 1 246 ? 169.24100 326.70000 15.90800  1.000 42.17145  ? 281 VAL F CB  1 
ATOM   1666 C CG1 . VAL A 1 246 ? 170.15600 325.65000 15.31600  1.000 37.74614  ? 281 VAL F CG1 1 
ATOM   1667 C CG2 . VAL A 1 246 ? 169.07100 326.40100 17.40100  1.000 43.40508  ? 281 VAL F CG2 1 
ATOM   1668 N N   . ARG A 1 247 ? 169.32200 328.54800 13.30600  1.000 43.95946  ? 282 ARG F N   1 
ATOM   1669 C CA  . ARG A 1 247 ? 169.70800 328.76100 11.91000  1.000 47.23081  ? 282 ARG F CA  1 
ATOM   1670 C C   . ARG A 1 247 ? 170.60800 329.95900 11.76900  1.000 44.15438  ? 282 ARG F C   1 
ATOM   1671 O O   . ARG A 1 247 ? 171.60700 329.90300 11.04300  1.000 45.85355  ? 282 ARG F O   1 
ATOM   1672 C CB  . ARG A 1 247 ? 168.51600 328.96600 10.97700  1.000 51.32200  ? 282 ARG F CB  1 
ATOM   1673 C CG  . ARG A 1 247 ? 167.62900 327.79000 10.76700  1.000 60.14685  ? 282 ARG F CG  1 
ATOM   1674 C CD  . ARG A 1 247 ? 166.53700 328.12100 9.74500   1.000 63.19363  ? 282 ARG F CD  1 
ATOM   1675 N NE  . ARG A 1 247 ? 165.76100 326.91200 9.52900   1.000 67.95914  ? 282 ARG F NE  1 
ATOM   1676 C CZ  . ARG A 1 247 ? 166.12300 325.98600 8.65400   1.000 66.51018  ? 282 ARG F CZ  1 
ATOM   1677 N NH1 . ARG A 1 247 ? 167.22300 326.11900 7.93000   1.000 62.67953  ? 282 ARG F NH1 1 
ATOM   1678 N NH2 . ARG A 1 247 ? 165.38800 324.88300 8.53400   1.000 71.00671  ? 282 ARG F NH2 1 
ATOM   1679 N N   . GLN A 1 248 ? 170.28000 331.04500 12.47200  1.000 41.65584  ? 283 GLN F N   1 
ATOM   1680 C CA  . GLN A 1 248 ? 171.10000 332.24100 12.36500  1.000 50.39668  ? 283 GLN F CA  1 
ATOM   1681 C C   . GLN A 1 248 ? 172.47900 332.05000 12.96500  1.000 50.68327  ? 283 GLN F C   1 
ATOM   1682 O O   . GLN A 1 248 ? 173.40600 332.73700 12.55000  1.000 48.89585  ? 283 GLN F O   1 
ATOM   1683 C CB  . GLN A 1 248 ? 170.39600 333.42700 13.02500  1.000 50.14951  ? 283 GLN F CB  1 
ATOM   1684 C CG  . GLN A 1 248 ? 169.14600 333.79500 12.28700  1.000 48.74039  ? 283 GLN F CG  1 
ATOM   1685 C CD  . GLN A 1 248 ? 168.33900 334.82500 12.98400  1.000 61.04512  ? 283 GLN F CD  1 
ATOM   1686 O OE1 . GLN A 1 248 ? 168.62400 335.17100 14.11900  1.000 64.71881  ? 283 GLN F OE1 1 
ATOM   1687 N NE2 . GLN A 1 248 ? 167.33500 335.36600 12.29300  1.000 70.08197  ? 283 GLN F NE2 1 
ATOM   1688 N N   . GLN A 1 249 ? 172.67000 331.05000 13.82000  1.000 48.58476  ? 284 GLN F N   1 
ATOM   1689 C CA  . GLN A 1 249 ? 173.98100 330.80100 14.39400  1.000 46.00169  ? 284 GLN F CA  1 
ATOM   1690 C C   . GLN A 1 249 ? 174.61800 329.53000 13.86200  1.000 51.06531  ? 284 GLN F C   1 
ATOM   1691 O O   . GLN A 1 249 ? 175.55300 329.01400 14.47600  1.000 53.90425  ? 284 GLN F O   1 
ATOM   1692 C CB  . GLN A 1 249 ? 173.81200 330.72700 15.91400  1.000 41.12533  ? 284 GLN F CB  1 
ATOM   1693 C CG  . GLN A 1 249 ? 173.40400 332.07800 16.48500  1.000 41.72230  ? 284 GLN F CG  1 
ATOM   1694 C CD  . GLN A 1 249 ? 173.31900 332.12300 18.00000  1.000 49.64621  ? 284 GLN F CD  1 
ATOM   1695 O OE1 . GLN A 1 249 ? 173.29700 331.08800 18.66400  1.000 46.67989  ? 284 GLN F OE1 1 
ATOM   1696 N NE2 . GLN A 1 249 ? 173.21500 333.33300 18.55300  1.000 47.32339  ? 284 GLN F NE2 1 
ATOM   1697 N N   . SER A 1 250 ? 174.27300 329.13100 12.63600  1.000 50.24000  ? 285 SER F N   1 
ATOM   1698 C CA  . SER A 1 250 ? 174.83100 327.92800 12.02900  1.000 50.26513  ? 285 SER F CA  1 
ATOM   1699 C C   . SER A 1 250 ? 175.51400 328.29500 10.72600  1.000 47.84050  ? 285 SER F C   1 
ATOM   1700 O O   . SER A 1 250 ? 175.32800 329.38100 10.19000  1.000 49.13635  ? 285 SER F O   1 
ATOM   1701 C CB  . SER A 1 250 ? 173.76100 326.86400 11.73900  1.000 47.99500  ? 285 SER F CB  1 
ATOM   1702 O OG  . SER A 1 250 ? 173.12200 326.42500 12.91200  1.000 49.45159  ? 285 SER F OG  1 
ATOM   1703 N N   . TYR A 1 251 ? 176.31500 327.36800 10.22100  1.000 46.44937  ? 286 TYR F N   1 
ATOM   1704 C CA  . TYR A 1 251 ? 176.99400 327.58000 8.95800   1.000 55.14710  ? 286 TYR F CA  1 
ATOM   1705 C C   . TYR A 1 251 ? 176.74900 326.37600 8.06000   1.000 57.27464  ? 286 TYR F C   1 
ATOM   1706 O O   . TYR A 1 251 ? 176.67400 325.23300 8.52800   1.000 56.31122  ? 286 TYR F O   1 
ATOM   1707 C CB  . TYR A 1 251 ? 178.49400 327.72800 9.15600   1.000 52.22042  ? 286 TYR F CB  1 
ATOM   1708 C CG  . TYR A 1 251 ? 178.92500 329.04200 9.76100   1.000 55.55920  ? 286 TYR F CG  1 
ATOM   1709 C CD1 . TYR A 1 251 ? 178.95200 329.19300 11.15600  1.000 50.89389  ? 286 TYR F CD1 1 
ATOM   1710 C CD2 . TYR A 1 251 ? 179.33700 330.11400 8.97300   1.000 54.86486  ? 286 TYR F CD2 1 
ATOM   1711 C CE1 . TYR A 1 251 ? 179.35700 330.38500 11.74400  1.000 53.69429  ? 286 TYR F CE1 1 
ATOM   1712 C CE2 . TYR A 1 251 ? 179.75200 331.31900 9.55900   1.000 53.66385  ? 286 TYR F CE2 1 
ATOM   1713 C CZ  . TYR A 1 251 ? 179.76300 331.43600 10.94300  1.000 53.51342  ? 286 TYR F CZ  1 
ATOM   1714 O OH  . TYR A 1 251 ? 180.16100 332.60300 11.54400  1.000 55.37415  ? 286 TYR F OH  1 
ATOM   1715 N N   . SER A 1 252 ? 176.64900 326.64500 6.76500   1.000 57.50259  ? 287 SER F N   1 
ATOM   1716 C CA  . SER A 1 252 ? 176.57100 325.61600 5.74000   1.000 57.18741  ? 287 SER F CA  1 
ATOM   1717 C C   . SER A 1 252 ? 177.78300 325.80200 4.84100   1.000 57.94451  ? 287 SER F C   1 
ATOM   1718 O O   . SER A 1 252 ? 177.89200 326.81700 4.14900   1.000 60.58790  ? 287 SER F O   1 
ATOM   1719 C CB  . SER A 1 252 ? 175.27100 325.72800 4.94400   1.000 58.88227  ? 287 SER F CB  1 
ATOM   1720 O OG  . SER A 1 252 ? 175.15700 324.67700 4.00800   1.000 63.35973  ? 287 SER F OG  1 
ATOM   1721 N N   . ILE A 1 253 ? 178.65400 324.80000 4.81600   1.000 57.82000  ? 288 ILE F N   1 
ATOM   1722 C CA  . ILE A 1 253 ? 179.93500 324.84700 4.12200   1.000 58.02271  ? 288 ILE F CA  1 
ATOM   1723 C C   . ILE A 1 253 ? 179.93400 323.81700 2.99900   1.000 63.43949  ? 288 ILE F C   1 
ATOM   1724 O O   . ILE A 1 253 ? 179.70300 322.62200 3.23600   1.000 61.33630  ? 288 ILE F O   1 
ATOM   1725 C CB  . ILE A 1 253 ? 181.12700 324.62300 5.06800   1.000 53.09295  ? 288 ILE F CB  1 
ATOM   1726 C CG1 . ILE A 1 253 ? 180.99400 325.49900 6.31700   1.000 58.43892  ? 288 ILE F CG1 1 
ATOM   1727 C CG2 . ILE A 1 253 ? 182.43500 324.79900 4.30100   1.000 51.73974  ? 288 ILE F CG2 1 
ATOM   1728 C CD1 . ILE A 1 253 ? 181.15700 324.76600 7.64000   1.000 55.57454  ? 288 ILE F CD1 1 
ATOM   1729 N N   . MET A 1 254 ? 180.30800 324.24900 1.81000   1.000 61.63946  ? 289 MET F N   1 
ATOM   1730 C CA  . MET A 1 254 ? 180.33500 323.31600 0.70700   1.000 65.04067  ? 289 MET F CA  1 
ATOM   1731 C C   . MET A 1 254 ? 181.61700 322.50600 0.78300   1.000 66.71942  ? 289 MET F C   1 
ATOM   1732 O O   . MET A 1 254 ? 182.71800 323.05600 0.80300   1.000 67.49850  ? 289 MET F O   1 
ATOM   1733 C CB  . MET A 1 254 ? 180.30500 324.08300 -0.61400  1.000 63.64090  ? 289 MET F CB  1 
ATOM   1734 C CG  . MET A 1 254 ? 179.00800 324.01700 -1.33800  1.000 70.57584  ? 289 MET F CG  1 
ATOM   1735 S SD  . MET A 1 254 ? 178.56800 322.38200 -1.97900  1.000 79.65824  ? 289 MET F SD  1 
ATOM   1736 C CE  . MET A 1 254 ? 180.06600 321.85200 -2.78000  1.000 75.72817  ? 289 MET F CE  1 
ATOM   1737 N N   . CYS A 1 255 ? 181.45300 321.19000 0.72200   1.000 66.69966  ? 290 CYS F N   1 
ATOM   1738 C CA  . CYS A 1 255 ? 182.50600 320.18300 0.79900   1.000 69.55216  ? 290 CYS F CA  1 
ATOM   1739 C C   . CYS A 1 255 ? 182.93100 319.79400 -0.60000  1.000 72.70902  ? 290 CYS F C   1 
ATOM   1740 O O   . CYS A 1 255 ? 183.89700 320.37300 -1.09900  1.000 65.24576  ? 290 CYS F O   1 
ATOM   1741 C CB  . CYS A 1 255 ? 182.11300 318.97300 1.64100   1.000 68.55337  ? 290 CYS F CB  1 
ATOM   1742 S SG  . CYS A 1 255 ? 182.15200 319.26500 3.44400   1.000 85.35595  ? 290 CYS F SG  1 
ATOM   1743 N N   . ILE A 1 256 ? 182.44200 318.65900 -1.11300  1.000 71.77564  ? 291 ILE F N   1 
ATOM   1744 C CA  . ILE A 1 256 ? 182.97100 318.17900 -2.38600  1.000 77.93996  ? 291 ILE F CA  1 
ATOM   1745 C C   . ILE A 1 256 ? 181.91800 317.57600 -3.31800  1.000 73.18837  ? 291 ILE F C   1 
ATOM   1746 O O   . ILE A 1 256 ? 180.84100 317.14300 -2.88200  1.000 67.54916  ? 291 ILE F O   1 
ATOM   1747 C CB  . ILE A 1 256 ? 184.05800 317.14400 -2.01000  1.000 78.20973  ? 291 ILE F CB  1 
ATOM   1748 C CG1 . ILE A 1 256 ? 185.05900 316.82400 -3.11900  1.000 82.92055  ? 291 ILE F CG1 1 
ATOM   1749 C CG2 . ILE A 1 256 ? 183.36900 315.86400 -1.49700  1.000 71.10152  ? 291 ILE F CG2 1 
ATOM   1750 C CD1 . ILE A 1 256 ? 186.05300 315.74800 -2.63300  1.000 83.75348  ? 291 ILE F CD1 1 
ATOM   1751 N N   . ILE A 1 257 ? 182.21500 317.64200 -4.63000  1.000 74.62857  ? 292 ILE F N   1 
ATOM   1752 C CA  . ILE A 1 257 ? 181.47100 316.91300 -5.66300  1.000 77.72079  ? 292 ILE F CA  1 
ATOM   1753 C C   . ILE A 1 257 ? 182.39600 315.84200 -6.21900  1.000 79.86412  ? 292 ILE F C   1 
ATOM   1754 O O   . ILE A 1 257 ? 183.31000 316.13100 -7.00500  1.000 74.29794  ? 292 ILE F O   1 
ATOM   1755 C CB  . ILE A 1 257 ? 180.99000 317.82900 -6.79700  1.000 74.91513  ? 292 ILE F CB  1 
ATOM   1756 C CG1 . ILE A 1 257 ? 179.88200 318.72900 -6.30500  1.000 76.78699  ? 292 ILE F CG1 1 
ATOM   1757 C CG2 . ILE A 1 257 ? 180.57600 317.02500 -8.01900  1.000 77.69402  ? 292 ILE F CG2 1 
ATOM   1758 C CD1 . ILE A 1 257 ? 178.74500 317.92700 -5.77000  1.000 76.33961  ? 292 ILE F CD1 1 
ATOM   1759 N N   . LYS A 1 258 ? 182.05800 314.59600 -5.93300  1.000 81.93229  ? 293 LYS F N   1 
ATOM   1760 C CA  . LYS A 1 258 ? 182.90700 313.48000 -6.31100  1.000 80.94437  ? 293 LYS F CA  1 
ATOM   1761 C C   . LYS A 1 258 ? 182.08400 312.20000 -6.33300  1.000 82.38288  ? 293 LYS F C   1 
ATOM   1762 O O   . LYS A 1 258 ? 181.31700 311.95400 -5.39000  1.000 79.22530  ? 293 LYS F O   1 
ATOM   1763 C CB  . LYS A 1 258 ? 184.11500 313.34200 -5.36300  1.000 82.54330  ? 293 LYS F CB  1 
ATOM   1764 C CG  . LYS A 1 258 ? 185.00100 312.14000 -5.70400  1.000 87.80065  ? 293 LYS F CG  1 
ATOM   1765 C CD  . LYS A 1 258 ? 185.70900 311.51500 -4.49200  1.000 88.00738  ? 293 LYS F CD  1 
ATOM   1766 C CE  . LYS A 1 258 ? 187.10400 312.09800 -4.26600  1.000 92.63883  ? 293 LYS F CE  1 
ATOM   1767 N NZ  . LYS A 1 258 ? 187.83000 311.43400 -3.13000  1.000 88.14134  ? 293 LYS F NZ  1 
ATOM   1768 N N   . GLU A 1 259 ? 182.17500 311.43300 -7.41800  1.000 82.07050  ? 294 GLU F N   1 
ATOM   1769 C CA  . GLU A 1 259 ? 181.54900 310.11400 -7.46900  1.000 76.92933  ? 294 GLU F CA  1 
ATOM   1770 C C   . GLU A 1 259 ? 180.04800 310.17000 -7.16600  1.000 76.72838  ? 294 GLU F C   1 
ATOM   1771 O O   . GLU A 1 259 ? 179.53900 309.47500 -6.27600  1.000 74.69476  ? 294 GLU F O   1 
ATOM   1772 C CB  . GLU A 1 259 ? 182.27300 309.23300 -6.44600  1.000 78.15154  ? 294 GLU F CB  1 
ATOM   1773 C CG  . GLU A 1 259 ? 183.75300 309.02800 -6.76800  1.000 82.57165  ? 294 GLU F CG  1 
ATOM   1774 C CD  . GLU A 1 259 ? 184.49600 308.21200 -5.71200  1.000 88.50554  ? 294 GLU F CD  1 
ATOM   1775 O OE1 . GLU A 1 259 ? 183.87500 307.81400 -4.70100  1.000 87.21927  ? 294 GLU F OE1 1 
ATOM   1776 O OE2 . GLU A 1 259 ? 185.72500 308.02600 -5.86300  1.000 89.98585  ? 294 GLU F OE2 1 
ATOM   1777 N N   . GLU A 1 260 ? 179.33200 310.98800 -7.94000  1.000 77.04904  ? 295 GLU F N   1 
ATOM   1778 C CA  . GLU A 1 260 ? 177.86800 311.04500 -7.86100  1.000 79.98767  ? 295 GLU F CA  1 
ATOM   1779 C C   . GLU A 1 260 ? 177.39000 311.46700 -6.47200  1.000 74.40158  ? 295 GLU F C   1 
ATOM   1780 O O   . GLU A 1 260 ? 176.31000 311.07300 -6.01300  1.000 70.74555  ? 295 GLU F O   1 
ATOM   1781 C CB  . GLU A 1 260 ? 177.26600 309.67800 -8.19700  1.000 77.00217  ? 295 GLU F CB  1 
ATOM   1782 C CG  . GLU A 1 260 ? 177.90500 308.97000 -9.36800  1.000 84.91313  ? 295 GLU F CG  1 
ATOM   1783 C CD  . GLU A 1 260 ? 177.24200 307.64600 -9.64500  1.000 90.40118  ? 295 GLU F CD  1 
ATOM   1784 O OE1 . GLU A 1 260 ? 177.62800 306.64800 -8.99000  1.000 92.78761  ? 295 GLU F OE1 1 
ATOM   1785 O OE2 . GLU A 1 260 ? 176.31100 307.61400 -10.47700 1.000 92.21091  ? 295 GLU F OE2 1 
ATOM   1786 N N   . VAL A 1 261 ? 178.16000 312.30500 -5.79900  1.000 74.98978  ? 296 VAL F N   1 
ATOM   1787 C CA  . VAL A 1 261 ? 177.79700 312.75800 -4.46600  1.000 71.90711  ? 296 VAL F CA  1 
ATOM   1788 C C   . VAL A 1 261 ? 178.09700 314.23300 -4.34600  1.000 71.32235  ? 296 VAL F C   1 
ATOM   1789 O O   . VAL A 1 261 ? 179.21000 314.67800 -4.65300  1.000 71.37362  ? 296 VAL F O   1 
ATOM   1790 C CB  . VAL A 1 261 ? 178.51600 311.99100 -3.34600  1.000 73.73864  ? 296 VAL F CB  1 
ATOM   1791 C CG1 . VAL A 1 261 ? 178.34200 312.74200 -2.01800  1.000 69.93853  ? 296 VAL F CG1 1 
ATOM   1792 C CG2 . VAL A 1 261 ? 177.95600 310.57200 -3.25800  1.000 78.37554  ? 296 VAL F CG2 1 
ATOM   1793 N N   . LEU A 1 262 ? 177.10600 314.98700 -3.90900  1.000 68.42101  ? 297 LEU F N   1 
ATOM   1794 C CA  . LEU A 1 262 ? 177.29200 316.38200 -3.56500  1.000 67.43941  ? 297 LEU F CA  1 
ATOM   1795 C C   . LEU A 1 262 ? 177.22200 316.44200 -2.05100  1.000 64.99387  ? 297 LEU F C   1 
ATOM   1796 O O   . LEU A 1 262 ? 176.20900 316.04500 -1.46900  1.000 60.14562  ? 297 LEU F O   1 
ATOM   1797 C CB  . LEU A 1 262 ? 176.22400 317.27300 -4.19500  1.000 65.63793  ? 297 LEU F CB  1 
ATOM   1798 C CG  . LEU A 1 262 ? 176.09200 318.64200 -3.51800  1.000 64.86720  ? 297 LEU F CG  1 
ATOM   1799 C CD1 . LEU A 1 262 ? 177.35800 319.43200 -3.64500  1.000 67.99398  ? 297 LEU F CD1 1 
ATOM   1800 C CD2 . LEU A 1 262 ? 174.94600 319.39500 -4.15200  1.000 69.11482  ? 297 LEU F CD2 1 
ATOM   1801 N N   . ALA A 1 263 ? 178.31300 316.83600 -1.40700  1.000 64.48748  ? 298 ALA F N   1 
ATOM   1802 C CA  . ALA A 1 263 ? 178.33000 316.83500 0.05000   1.000 65.72485  ? 298 ALA F CA  1 
ATOM   1803 C C   . ALA A 1 263 ? 178.67100 318.22900 0.55400   1.000 63.34064  ? 298 ALA F C   1 
ATOM   1804 O O   . ALA A 1 263 ? 179.61600 318.87200 0.06200   1.000 57.01326  ? 298 ALA F O   1 
ATOM   1805 C CB  . ALA A 1 263 ? 179.33000 315.80500 0.60500   1.000 63.78950  ? 298 ALA F CB  1 
ATOM   1806 N N   . TYR A 1 264 ? 177.98800 318.60500 1.63700   1.000 62.40994  ? 299 TYR F N   1 
ATOM   1807 C CA  . TYR A 1 264 ? 178.23800 319.85800 2.33400   1.000 62.62368  ? 299 TYR F CA  1 
ATOM   1808 C C   . TYR A 1 264 ? 177.92800 319.69600 3.81600   1.000 62.98879  ? 299 TYR F C   1 
ATOM   1809 O O   . TYR A 1 264 ? 177.05800 318.91200 4.21000   1.000 56.00520  ? 299 TYR F O   1 
ATOM   1810 C CB  . TYR A 1 264 ? 177.43300 321.03600 1.74500   1.000 57.72551  ? 299 TYR F CB  1 
ATOM   1811 C CG  . TYR A 1 264 ? 175.91100 320.94700 1.73600   1.000 54.17874  ? 299 TYR F CG  1 
ATOM   1812 C CD1 . TYR A 1 264 ? 175.23600 320.37300 0.66400   1.000 63.89035  ? 299 TYR F CD1 1 
ATOM   1813 C CD2 . TYR A 1 264 ? 175.15400 321.42200 2.78800   1.000 56.76386  ? 299 TYR F CD2 1 
ATOM   1814 C CE1 . TYR A 1 264 ? 173.84000 320.29700 0.63100   1.000 55.66013  ? 299 TYR F CE1 1 
ATOM   1815 C CE2 . TYR A 1 264 ? 173.75100 321.34500 2.77500   1.000 61.46867  ? 299 TYR F CE2 1 
ATOM   1816 C CZ  . TYR A 1 264 ? 173.10500 320.77800 1.68400   1.000 61.68885  ? 299 TYR F CZ  1 
ATOM   1817 O OH  . TYR A 1 264 ? 171.72700 320.69700 1.64300   1.000 57.61568  ? 299 TYR F OH  1 
ATOM   1818 N N   . VAL A 1 265 ? 178.66900 320.44300 4.63800   1.000 61.41247  ? 300 VAL F N   1 
ATOM   1819 C CA  . VAL A 1 265 ? 178.61700 320.30300 6.08800   1.000 58.14208  ? 300 VAL F CA  1 
ATOM   1820 C C   . VAL A 1 265 ? 177.73300 321.38300 6.67300   1.000 55.64481  ? 300 VAL F C   1 
ATOM   1821 O O   . VAL A 1 265 ? 177.83500 322.55200 6.29200   1.000 58.54863  ? 300 VAL F O   1 
ATOM   1822 C CB  . VAL A 1 265 ? 180.03400 320.38600 6.68900   1.000 62.55972  ? 300 VAL F CB  1 
ATOM   1823 C CG1 . VAL A 1 265 ? 179.98400 320.48700 8.18600   1.000 60.12876  ? 300 VAL F CG1 1 
ATOM   1824 C CG2 . VAL A 1 265 ? 180.85500 319.16400 6.32900   1.000 69.20815  ? 300 VAL F CG2 1 
ATOM   1825 N N   . VAL A 1 266 ? 176.82000 320.98300 7.54700   1.000 52.92678  ? 301 VAL F N   1 
ATOM   1826 C CA  . VAL A 1 266 ? 176.05900 321.92300 8.34400   1.000 56.12057  ? 301 VAL F CA  1 
ATOM   1827 C C   . VAL A 1 266 ? 176.64600 321.88500 9.75100   1.000 57.52179  ? 301 VAL F C   1 
ATOM   1828 O O   . VAL A 1 266 ? 176.72000 320.82000 10.38300  1.000 59.92996  ? 301 VAL F O   1 
ATOM   1829 C CB  . VAL A 1 266 ? 174.55700 321.60000 8.32100   1.000 57.82448  ? 301 VAL F CB  1 
ATOM   1830 C CG1 . VAL A 1 266 ? 173.80800 322.48700 9.26800   1.000 57.48031  ? 301 VAL F CG1 1 
ATOM   1831 C CG2 . VAL A 1 266 ? 174.00300 321.83400 6.90700   1.000 57.67455  ? 301 VAL F CG2 1 
ATOM   1832 N N   . GLN A 1 267 ? 177.09100 323.04800 10.21500  1.000 57.21861  ? 302 GLN F N   1 
ATOM   1833 C CA  . GLN A 1 267 ? 177.76500 323.24800 11.49600  1.000 53.40460  ? 302 GLN F CA  1 
ATOM   1834 C C   . GLN A 1 267 ? 176.77200 323.91200 12.43800  1.000 48.68845  ? 302 GLN F C   1 
ATOM   1835 O O   . GLN A 1 267 ? 176.44100 325.08700 12.24500  1.000 51.45779  ? 302 GLN F O   1 
ATOM   1836 C CB  . GLN A 1 267 ? 178.98700 324.13200 11.32200  1.000 55.61052  ? 302 GLN F CB  1 
ATOM   1837 C CG  . GLN A 1 267 ? 179.92700 324.14800 12.46000  1.000 52.21974  ? 302 GLN F CG  1 
ATOM   1838 C CD  . GLN A 1 267 ? 181.16300 324.96000 12.12000  1.000 56.08824  ? 302 GLN F CD  1 
ATOM   1839 O OE1 . GLN A 1 267 ? 182.08200 324.49400 11.44500  1.000 58.31129  ? 302 GLN F OE1 1 
ATOM   1840 N NE2 . GLN A 1 267 ? 181.17100 326.21200 12.58100  1.000 54.53669  ? 302 GLN F NE2 1 
ATOM   1841 N N   . LEU A 1 268 ? 176.26600 323.18000 13.39800  1.000 48.20238  ? 303 LEU F N   1 
ATOM   1842 C CA  . LEU A 1 268 ? 175.21700 323.66900 14.28600  1.000 50.80058  ? 303 LEU F CA  1 
ATOM   1843 C C   . LEU A 1 268 ? 175.78200 324.06200 15.65200  1.000 55.69099  ? 303 LEU F C   1 
ATOM   1844 O O   . LEU A 1 268 ? 176.76500 323.47500 16.12200  1.000 50.85924  ? 303 LEU F O   1 
ATOM   1845 C CB  . LEU A 1 268 ? 174.15600 322.59100 14.50800  1.000 50.76263  ? 303 LEU F CB  1 
ATOM   1846 C CG  . LEU A 1 268 ? 173.41900 322.05300 13.28000  1.000 54.01464  ? 303 LEU F CG  1 
ATOM   1847 C CD1 . LEU A 1 268 ? 172.14200 321.37400 13.70600  1.000 52.38526  ? 303 LEU F CD1 1 
ATOM   1848 C CD2 . LEU A 1 268 ? 173.12500 323.16800 12.31000  1.000 54.78197  ? 303 LEU F CD2 1 
ATOM   1849 N N   . PRO A 1 269 ? 175.20000 325.05000 16.32400  1.000 49.52006  ? 304 PRO F N   1 
ATOM   1850 C CA  . PRO A 1 269 ? 175.77700 325.50200 17.59200  1.000 47.00761  ? 304 PRO F CA  1 
ATOM   1851 C C   . PRO A 1 269 ? 175.44800 324.51400 18.69900  1.000 50.55524  ? 304 PRO F C   1 
ATOM   1852 O O   . PRO A 1 269 ? 174.35600 323.93500 18.72700  1.000 44.42333  ? 304 PRO F O   1 
ATOM   1853 C CB  . PRO A 1 269 ? 175.07500 326.83800 17.85000  1.000 45.09401  ? 304 PRO F CB  1 
ATOM   1854 C CG  . PRO A 1 269 ? 173.73700 326.66600 17.16700  1.000 46.49460  ? 304 PRO F CG  1 
ATOM   1855 C CD  . PRO A 1 269 ? 174.01900 325.83500 15.93600  1.000 47.89067  ? 304 PRO F CD  1 
ATOM   1856 N N   . LEU A 1 270 ? 176.41500 324.31900 19.60700  1.000 47.98675  ? 305 LEU F N   1 
ATOM   1857 C CA  . LEU A 1 270 ? 176.24800 323.56800 20.85200  1.000 46.06484  ? 305 LEU F CA  1 
ATOM   1858 C C   . LEU A 1 270 ? 176.40800 324.57600 21.97600  1.000 46.97607  ? 305 LEU F C   1 
ATOM   1859 O O   . LEU A 1 270 ? 177.47900 325.19400 22.12600  1.000 47.35967  ? 305 LEU F O   1 
ATOM   1860 C CB  . LEU A 1 270 ? 177.24900 322.41900 20.98100  1.000 45.14003  ? 305 LEU F CB  1 
ATOM   1861 C CG  . LEU A 1 270 ? 176.99500 321.18100 20.13200  1.000 54.06168  ? 305 LEU F CG  1 
ATOM   1862 C CD1 . LEU A 1 270 ? 178.03300 320.12400 20.41500  1.000 52.64464  ? 305 LEU F CD1 1 
ATOM   1863 C CD2 . LEU A 1 270 ? 175.59000 320.62300 20.41600  1.000 53.58782  ? 305 LEU F CD2 1 
ATOM   1864 N N   . TYR A 1 271 ? 175.37700 324.69900 22.78900  1.000 43.19306  ? 306 TYR F N   1 
ATOM   1865 C CA  . TYR A 1 271 ? 175.34700 325.69700 23.85100  1.000 47.59062  ? 306 TYR F CA  1 
ATOM   1866 C C   . TYR A 1 271 ? 175.81600 325.04700 25.15100  1.000 48.12548  ? 306 TYR F C   1 
ATOM   1867 O O   . TYR A 1 271 ? 175.02700 324.45800 25.88400  1.000 49.75259  ? 306 TYR F O   1 
ATOM   1868 C CB  . TYR A 1 271 ? 173.93700 326.25300 23.99600  1.000 43.47761  ? 306 TYR F CB  1 
ATOM   1869 C CG  . TYR A 1 271 ? 173.45000 326.90800 22.72300  1.000 49.04398  ? 306 TYR F CG  1 
ATOM   1870 C CD1 . TYR A 1 271 ? 173.83100 328.19900 22.38100  1.000 44.08620  ? 306 TYR F CD1 1 
ATOM   1871 C CD2 . TYR A 1 271 ? 172.54500 326.24600 21.89500  1.000 48.64727  ? 306 TYR F CD2 1 
ATOM   1872 C CE1 . TYR A 1 271 ? 173.37900 328.79500 21.21800  1.000 48.07613  ? 306 TYR F CE1 1 
ATOM   1873 C CE2 . TYR A 1 271 ? 172.07500 326.83500 20.74400  1.000 48.48876  ? 306 TYR F CE2 1 
ATOM   1874 C CZ  . TYR A 1 271 ? 172.48000 328.11200 20.41600  1.000 50.67689  ? 306 TYR F CZ  1 
ATOM   1875 O OH  . TYR A 1 271 ? 172.01600 328.68600 19.26500  1.000 48.41762  ? 306 TYR F OH  1 
ATOM   1876 N N   . GLY A 1 272 ? 177.12800 325.14800 25.41100  1.000 46.51956  ? 307 GLY F N   1 
ATOM   1877 C CA  . GLY A 1 272 ? 177.75900 324.64900 26.62400  1.000 40.74281  ? 307 GLY F CA  1 
ATOM   1878 C C   . GLY A 1 272 ? 177.43300 325.40900 27.89500  1.000 43.64553  ? 307 GLY F C   1 
ATOM   1879 O O   . GLY A 1 272 ? 177.79100 324.93500 28.98000  1.000 41.76624  ? 307 GLY F O   1 
ATOM   1880 N N   . VAL A 1 273 ? 176.97900 326.65200 27.79400  1.000 43.00075  ? 308 VAL F N   1 
ATOM   1881 C CA  . VAL A 1 273 ? 176.57600 327.44000 28.96200  1.000 43.98422  ? 308 VAL F CA  1 
ATOM   1882 C C   . VAL A 1 273 ? 175.07600 327.66600 28.91300  1.000 49.24461  ? 308 VAL F C   1 
ATOM   1883 O O   . VAL A 1 273 ? 174.57500 328.28300 27.96300  1.000 47.91968  ? 308 VAL F O   1 
ATOM   1884 C CB  . VAL A 1 273 ? 177.34000 328.76000 29.03600  1.000 40.27152  ? 308 VAL F CB  1 
ATOM   1885 C CG1 . VAL A 1 273 ? 177.20400 329.33700 30.40300  1.000 40.04884  ? 308 VAL F CG1 1 
ATOM   1886 C CG2 . VAL A 1 273 ? 178.79700 328.47000 28.78400  1.000 40.82036  ? 308 VAL F CG2 1 
ATOM   1887 N N   . ILE A 1 274 ? 174.35500 327.14500 29.90000  1.000 45.21540  ? 309 ILE F N   1 
ATOM   1888 C CA  . ILE A 1 274 ? 172.90400 327.25600 29.94100  1.000 47.13095  ? 309 ILE F CA  1 
ATOM   1889 C C   . ILE A 1 274 ? 172.37900 327.72200 31.27900  1.000 46.69785  ? 309 ILE F C   1 
ATOM   1890 O O   . ILE A 1 274 ? 172.81300 327.25500 32.33200  1.000 50.87107  ? 309 ILE F O   1 
ATOM   1891 C CB  . ILE A 1 274 ? 172.23000 325.91700 29.56300  1.000 51.14004  ? 309 ILE F CB  1 
ATOM   1892 C CG1 . ILE A 1 274 ? 172.65700 325.49800 28.16800  1.000 52.41547  ? 309 ILE F CG1 1 
ATOM   1893 C CG2 . ILE A 1 274 ? 170.71800 325.97800 29.75100  1.000 54.91190  ? 309 ILE F CG2 1 
ATOM   1894 C CD1 . ILE A 1 274 ? 171.89900 326.26800 27.12700  1.000 57.24647  ? 309 ILE F CD1 1 
ATOM   1895 N N   . ASP A 1 275 ? 171.39500 328.59600 31.21800  1.000 42.84861  ? 310 ASP F N   1 
ATOM   1896 C CA  . ASP A 1 275 ? 170.65800 329.13700 32.35300  1.000 45.18927  ? 310 ASP F CA  1 
ATOM   1897 C C   . ASP A 1 275 ? 171.52200 329.86200 33.37300  1.000 45.65806  ? 310 ASP F C   1 
ATOM   1898 O O   . ASP A 1 275 ? 171.22400 329.83900 34.56800  1.000 48.67949  ? 310 ASP F O   1 
ATOM   1899 C CB  . ASP A 1 275 ? 169.95300 327.96200 33.04800  1.000 49.22876  ? 310 ASP F CB  1 
ATOM   1900 C CG  . ASP A 1 275 ? 168.72400 327.48200 32.28500  1.000 54.84759  ? 310 ASP F CG  1 
ATOM   1901 O OD1 . ASP A 1 275 ? 168.27000 328.19800 31.37000  1.000 57.02185  ? 310 ASP F OD1 1 
ATOM   1902 O OD2 . ASP A 1 275 ? 168.27100 326.33800 32.52800  1.000 62.47013  ? 310 ASP F OD2 1 
ATOM   1903 N N   . THR A 1 276 ? 172.48100 330.48300 32.96900  1.000 47.72742  ? 311 THR F N   1 
ATOM   1904 C CA  . THR A 1 276 ? 173.26700 331.31500 33.87300  1.000 44.57491  ? 311 THR F CA  1 
ATOM   1905 C C   . THR A 1 276 ? 172.67500 332.70900 33.78500  1.000 42.44072  ? 311 THR F C   1 
ATOM   1906 O O   . THR A 1 276 ? 172.06200 333.04900 32.76800  1.000 45.33902  ? 311 THR F O   1 
ATOM   1907 C CB  . THR A 1 276 ? 174.75900 331.32500 33.58800  1.000 41.79849  ? 311 THR F CB  1 
ATOM   1908 O OG1 . THR A 1 276 ? 175.02400 331.87100 32.30300  1.000 36.55875  ? 311 THR F OG1 1 
ATOM   1909 C CG2 . THR A 1 276 ? 175.34000 329.89000 33.72900  1.000 43.82911  ? 311 THR F CG2 1 
ATOM   1910 N N   . PRO A 1 277 ? 172.72300 333.46000 34.86800  1.000 40.83580  ? 312 PRO F N   1 
ATOM   1911 C CA  . PRO A 1 277 ? 172.18600 334.82500 34.85500  1.000 45.02173  ? 312 PRO F CA  1 
ATOM   1912 C C   . PRO A 1 277 ? 172.87600 335.69300 33.81100  1.000 42.76571  ? 312 PRO F C   1 
ATOM   1913 O O   . PRO A 1 277 ? 174.09600 335.63700 33.62800  1.000 43.31176  ? 312 PRO F O   1 
ATOM   1914 C CB  . PRO A 1 277 ? 172.52600 335.35300 36.25900  1.000 44.73352  ? 312 PRO F CB  1 
ATOM   1915 C CG  . PRO A 1 277 ? 172.70200 334.12100 37.11600  1.000 41.75391  ? 312 PRO F CG  1 
ATOM   1916 C CD  . PRO A 1 277 ? 173.30500 333.09300 36.18100  1.000 41.22359  ? 312 PRO F CD  1 
ATOM   1917 N N   . CYS A 1 278 ? 172.08500 336.49300 33.11900  1.000 40.09896  ? 313 CYS F N   1 
ATOM   1918 C CA  . CYS A 1 278 ? 172.60100 337.40100 32.09900  1.000 41.96689  ? 313 CYS F CA  1 
ATOM   1919 C C   . CYS A 1 278 ? 171.91700 338.73000 32.36500  1.000 43.80987  ? 313 CYS F C   1 
ATOM   1920 O O   . CYS A 1 278 ? 170.77100 338.75700 32.82700  1.000 41.45459  ? 313 CYS F O   1 
ATOM   1921 C CB  . CYS A 1 278 ? 172.23400 336.98900 30.67200  1.000 39.87381  ? 313 CYS F CB  1 
ATOM   1922 S SG  . CYS A 1 278 ? 173.02800 335.53400 29.94300  1.000 46.55711  ? 313 CYS F SG  1 
ATOM   1923 N N   . TRP A 1 279 ? 172.64000 339.82500 32.14000  1.000 38.81833  ? 314 TRP F N   1 
ATOM   1924 C CA  . TRP A 1 279 ? 172.09100 341.15700 32.30100  1.000 40.48929  ? 314 TRP F CA  1 
ATOM   1925 C C   . TRP A 1 279 ? 172.62400 342.05200 31.19300  1.000 43.92415  ? 314 TRP F C   1 
ATOM   1926 O O   . TRP A 1 279 ? 173.65100 341.77400 30.57500  1.000 40.08029  ? 314 TRP F O   1 
ATOM   1927 C CB  . TRP A 1 279 ? 172.40200 341.75200 33.68100  1.000 38.30085  ? 314 TRP F CB  1 
ATOM   1928 C CG  . TRP A 1 279 ? 173.85300 341.91900 33.99900  1.000 40.52664  ? 314 TRP F CG  1 
ATOM   1929 C CD1 . TRP A 1 279 ? 174.56800 343.07300 33.96100  1.000 41.42136  ? 314 TRP F CD1 1 
ATOM   1930 C CD2 . TRP A 1 279 ? 174.75600 340.90400 34.45900  1.000 41.86963  ? 314 TRP F CD2 1 
ATOM   1931 N NE1 . TRP A 1 279 ? 175.87100 342.84000 34.34400  1.000 37.52594  ? 314 TRP F NE1 1 
ATOM   1932 C CE2 . TRP A 1 279 ? 176.00500 341.51700 34.66400  1.000 40.56629  ? 314 TRP F CE2 1 
ATOM   1933 C CE3 . TRP A 1 279 ? 174.62200 339.53900 34.72900  1.000 41.99015  ? 314 TRP F CE3 1 
ATOM   1934 C CZ2 . TRP A 1 279 ? 177.12400 340.80700 35.09500  1.000 42.74397  ? 314 TRP F CZ2 1 
ATOM   1935 C CZ3 . TRP A 1 279 ? 175.73200 338.83700 35.17400  1.000 41.50415  ? 314 TRP F CZ3 1 
ATOM   1936 C CH2 . TRP A 1 279 ? 176.96600 339.47300 35.35000  1.000 40.09900  ? 314 TRP F CH2 1 
ATOM   1937 N N   . LYS A 1 280 ? 171.88000 343.11400 30.91000  1.000 39.88475  ? 315 LYS F N   1 
ATOM   1938 C CA  . LYS A 1 280 ? 172.23700 344.04100 29.83900  1.000 40.69036  ? 315 LYS F CA  1 
ATOM   1939 C C   . LYS A 1 280 ? 172.47000 345.41800 30.42500  1.000 40.78887  ? 315 LYS F C   1 
ATOM   1940 O O   . LYS A 1 280 ? 171.62100 345.91500 31.17700  1.000 40.82588  ? 315 LYS F O   1 
ATOM   1941 C CB  . LYS A 1 280 ? 171.15700 344.13700 28.74700  1.000 45.15555  ? 315 LYS F CB  1 
ATOM   1942 C CG  . LYS A 1 280 ? 171.60700 344.96000 27.53400  1.000 40.94713  ? 315 LYS F CG  1 
ATOM   1943 C CD  . LYS A 1 280 ? 170.67600 344.88200 26.31800  1.000 40.18486  ? 315 LYS F CD  1 
ATOM   1944 C CE  . LYS A 1 280 ? 171.32400 345.59500 25.11900  1.000 45.95544  ? 315 LYS F CE  1 
ATOM   1945 N NZ  . LYS A 1 280 ? 170.50300 345.49100 23.88800  1.000 52.73805  ? 315 LYS F NZ  1 
ATOM   1946 N N   . LEU A 1 281 ? 173.66800 345.96600 30.19200  1.000 35.69080  ? 316 LEU F N   1 
ATOM   1947 C CA  . LEU A 1 281 ? 174.03400 347.28900 30.68300  1.000 35.46578  ? 316 LEU F CA  1 
ATOM   1948 C C   . LEU A 1 281 ? 173.72300 348.33300 29.59900  1.000 39.57704  ? 316 LEU F C   1 
ATOM   1949 O O   . LEU A 1 281 ? 174.15700 348.18500 28.44300  1.000 36.43337  ? 316 LEU F O   1 
ATOM   1950 C CB  . LEU A 1 281 ? 175.51500 347.32000 31.07900  1.000 37.71225  ? 316 LEU F CB  1 
ATOM   1951 C CG  . LEU A 1 281 ? 176.08000 348.69700 31.45500  1.000 42.97883  ? 316 LEU F CG  1 
ATOM   1952 C CD1 . LEU A 1 281 ? 175.36100 349.22100 32.69700  1.000 34.43031  ? 316 LEU F CD1 1 
ATOM   1953 C CD2 . LEU A 1 281 ? 177.60500 348.67900 31.66000  1.000 38.02780  ? 316 LEU F CD2 1 
ATOM   1954 N N   . HIS A 1 282 ? 173.01200 349.40000 29.98900  1.000 38.31358  ? 317 HIS F N   1 
ATOM   1955 C CA  . HIS A 1 282 ? 172.67900 350.53600 29.14000  1.000 35.61000  ? 317 HIS F CA  1 
ATOM   1956 C C   . HIS A 1 282 ? 173.34400 351.78800 29.72200  1.000 37.72737  ? 317 HIS F C   1 
ATOM   1957 O O   . HIS A 1 282 ? 173.34300 351.97700 30.94700  1.000 38.00777  ? 317 HIS F O   1 
ATOM   1958 C CB  . HIS A 1 282 ? 171.16300 350.75100 29.16200  1.000 44.44416  ? 317 HIS F CB  1 
ATOM   1959 C CG  . HIS A 1 282 ? 170.35100 349.53300 28.82100  1.000 40.83102  ? 317 HIS F CG  1 
ATOM   1960 N ND1 . HIS A 1 282 ? 169.95200 349.22000 27.53800  1.000 45.48832  ? 317 HIS F ND1 1 
ATOM   1961 C CD2 . HIS A 1 282 ? 169.76900 348.60800 29.62900  1.000 41.49038  ? 317 HIS F CD2 1 
ATOM   1962 C CE1 . HIS A 1 282 ? 169.22500 348.11500 27.56100  1.000 41.91736  ? 317 HIS F CE1 1 
ATOM   1963 N NE2 . HIS A 1 282 ? 169.07500 347.74000 28.82200  1.000 41.74745  ? 317 HIS F NE2 1 
ATOM   1964 N N   . THR A 1 283 ? 174.00700 352.58300 28.88500  1.000 37.45908  ? 318 THR F N   1 
ATOM   1965 C CA  . THR A 1 283 ? 174.70900 353.78000 29.35300  1.000 40.10254  ? 318 THR F CA  1 
ATOM   1966 C C   . THR A 1 283 ? 174.28500 354.99200 28.52400  1.000 39.63807  ? 318 THR F C   1 
ATOM   1967 O O   . THR A 1 283 ? 173.89200 354.83500 27.37200  1.000 38.75841  ? 318 THR F O   1 
ATOM   1968 C CB  . THR A 1 283 ? 176.23800 353.61600 29.27000  1.000 39.67528  ? 318 THR F CB  1 
ATOM   1969 O OG1 . THR A 1 283 ? 176.60900 353.50500 27.89800  1.000 39.76734  ? 318 THR F OG1 1 
ATOM   1970 C CG2 . THR A 1 283 ? 176.63600 352.31100 29.98600  1.000 37.00307  ? 318 THR F CG2 1 
ATOM   1971 N N   . SER A 1 284 ? 174.37500 356.19400 29.10900  1.000 34.45632  ? 319 SER F N   1 
ATOM   1972 C CA  . SER A 1 284 ? 174.00300 357.44400 28.45300  1.000 38.37328  ? 319 SER F CA  1 
ATOM   1973 C C   . SER A 1 284 ? 174.85800 358.57500 29.02100  1.000 35.36233  ? 319 SER F C   1 
ATOM   1974 O O   . SER A 1 284 ? 175.28600 358.49000 30.17300  1.000 36.71335  ? 319 SER F O   1 
ATOM   1975 C CB  . SER A 1 284 ? 172.50400 357.73500 28.63800  1.000 38.18516  ? 319 SER F CB  1 
ATOM   1976 O OG  . SER A 1 284 ? 172.10300 358.76700 27.79000  1.000 42.88976  ? 319 SER F OG  1 
ATOM   1977 N N   . PRO A 1 285 ? 175.14800 359.61700 28.24300  1.000 36.45257  ? 320 PRO F N   1 
ATOM   1978 C CA  . PRO A 1 285 ? 176.03900 360.67500 28.73200  1.000 36.70574  ? 320 PRO F CA  1 
ATOM   1979 C C   . PRO A 1 285 ? 175.48100 361.40200 29.95700  1.000 38.84796  ? 320 PRO F C   1 
ATOM   1980 O O   . PRO A 1 285 ? 174.32200 361.81800 29.98400  1.000 35.66020  ? 320 PRO F O   1 
ATOM   1981 C CB  . PRO A 1 285 ? 176.15100 361.62000 27.53500  1.000 39.31296  ? 320 PRO F CB  1 
ATOM   1982 C CG  . PRO A 1 285 ? 175.84600 360.78500 26.34300  1.000 42.66258  ? 320 PRO F CG  1 
ATOM   1983 C CD  . PRO A 1 285 ? 174.79600 359.80100 26.82200  1.000 40.92417  ? 320 PRO F CD  1 
ATOM   1984 N N   . LEU A 1 286 ? 176.37200 361.65300 30.91500  1.000 37.20035  ? 321 LEU F N   1 
ATOM   1985 C CA  . LEU A 1 286 ? 176.12300 362.34300 32.18700  1.000 37.60111  ? 321 LEU F CA  1 
ATOM   1986 C C   . LEU A 1 286 ? 176.96100 363.60700 32.21400  1.000 40.29563  ? 321 LEU F C   1 
ATOM   1987 O O   . LEU A 1 286 ? 178.19400 363.53600 32.28500  1.000 41.02532  ? 321 LEU F O   1 
ATOM   1988 C CB  . LEU A 1 286 ? 176.46000 361.45300 33.37700  1.000 34.55387  ? 321 LEU F CB  1 
ATOM   1989 C CG  . LEU A 1 286 ? 176.20600 362.14300 34.71100  1.000 42.52523  ? 321 LEU F CG  1 
ATOM   1990 C CD1 . LEU A 1 286 ? 174.72600 362.39500 34.97000  1.000 35.99409  ? 321 LEU F CD1 1 
ATOM   1991 C CD2 . LEU A 1 286 ? 176.78300 361.24700 35.85400  1.000 34.15318  ? 321 LEU F CD2 1 
ATOM   1992 N N   . CYS A 1 287 ? 176.31200 364.73200 31.93800  1.000 38.54344  ? 322 CYS F N   1 
ATOM   1993 C CA  . CYS A 1 287 ? 176.98300 366.02100 31.87700  1.000 40.90383  ? 322 CYS F CA  1 
ATOM   1994 C C   . CYS A 1 287 ? 176.51300 366.92700 33.00300  1.000 39.32814  ? 322 CYS F C   1 
ATOM   1995 O O   . CYS A 1 287 ? 175.41900 366.75600 33.54600  1.000 43.88120  ? 322 CYS F O   1 
ATOM   1996 C CB  . CYS A 1 287 ? 176.69200 366.69600 30.52500  1.000 37.92043  ? 322 CYS F CB  1 
ATOM   1997 S SG  . CYS A 1 287 ? 177.05900 365.68000 29.09300  1.000 41.92789  ? 322 CYS F SG  1 
ATOM   1998 N N   . THR A 1 288 ? 177.26200 368.00200 33.22200  1.000 44.74883  ? 323 THR F N   1 
ATOM   1999 C CA  . THR A 1 288 ? 176.79900 369.02500 34.14000  1.000 48.47111  ? 323 THR F CA  1 
ATOM   2000 C C   . THR A 1 288 ? 175.89300 369.94800 33.33500  1.000 48.70085  ? 323 THR F C   1 
ATOM   2001 O O   . THR A 1 288 ? 175.92700 369.96700 32.10100  1.000 48.05469  ? 323 THR F O   1 
ATOM   2002 C CB  . THR A 1 288 ? 177.96700 369.84500 34.73400  1.000 47.36540  ? 323 THR F CB  1 
ATOM   2003 O OG1 . THR A 1 288 ? 178.76600 370.35900 33.66900  1.000 45.29575  ? 323 THR F OG1 1 
ATOM   2004 C CG2 . THR A 1 288 ? 178.83200 369.06900 35.70800  1.000 43.59145  ? 323 THR F CG2 1 
ATOM   2005 N N   . THR A 1 289 ? 175.05400 370.69300 34.04100  1.000 53.60618  ? 324 THR F N   1 
ATOM   2006 C CA  . THR A 1 289 ? 174.02900 371.50000 33.38900  1.000 55.45032  ? 324 THR F CA  1 
ATOM   2007 C C   . THR A 1 289 ? 174.17900 373.00700 33.60200  1.000 65.05551  ? 324 THR F C   1 
ATOM   2008 O O   . THR A 1 289 ? 173.19400 373.69600 33.88800  1.000 66.21146  ? 324 THR F O   1 
ATOM   2009 C CB  . THR A 1 289 ? 172.66700 371.02800 33.85400  1.000 48.85590  ? 324 THR F CB  1 
ATOM   2010 O OG1 . THR A 1 289 ? 172.61900 371.13600 35.26700  1.000 50.69083  ? 324 THR F OG1 1 
ATOM   2011 C CG2 . THR A 1 289 ? 172.42800 369.58100 33.43000  1.000 51.04970  ? 324 THR F CG2 1 
ATOM   2012 N N   . ASN A 1 290 ? 175.37500 373.54300 33.41900  1.000 64.48832  ? 325 ASN F N   1 
ATOM   2013 C CA  . ASN A 1 290 ? 175.53100 374.98500 33.45400  1.000 70.56794  ? 325 ASN F CA  1 
ATOM   2014 C C   . ASN A 1 290 ? 174.96600 375.61800 32.19000  1.000 75.79938  ? 325 ASN F C   1 
ATOM   2015 O O   . ASN A 1 290 ? 174.89900 374.99600 31.12300  1.000 69.05719  ? 325 ASN F O   1 
ATOM   2016 C CB  . ASN A 1 290 ? 177.00400 375.36400 33.60600  1.000 71.73642  ? 325 ASN F CB  1 
ATOM   2017 C CG  . ASN A 1 290 ? 177.61800 374.78800 34.85700  1.000 71.97070  ? 325 ASN F CG  1 
ATOM   2018 O OD1 . ASN A 1 290 ? 177.01500 374.82700 35.93800  1.000 73.75144  ? 325 ASN F OD1 1 
ATOM   2019 N ND2 . ASN A 1 290 ? 178.82300 374.23100 34.72100  1.000 72.32653  ? 325 ASN F ND2 1 
ATOM   2020 N N   . THR A 1 291 ? 174.65500 376.91500 32.30300  1.000 78.52249  ? 326 THR F N   1 
ATOM   2021 C CA  . THR A 1 291 ? 173.95700 377.69500 31.28500  1.000 82.11629  ? 326 THR F CA  1 
ATOM   2022 C C   . THR A 1 291 ? 174.90400 378.32100 30.26700  1.000 81.70719  ? 326 THR F C   1 
ATOM   2023 O O   . THR A 1 291 ? 174.43900 378.85400 29.25500  1.000 89.08072  ? 326 THR F O   1 
ATOM   2024 C CB  . THR A 1 291 ? 173.10100 378.79600 31.94200  1.000 86.43375  ? 326 THR F CB  1 
ATOM   2025 O OG1 . THR A 1 291 ? 173.89900 379.54800 32.87100  1.000 91.30630  ? 326 THR F OG1 1 
ATOM   2026 C CG2 . THR A 1 291 ? 171.89100 378.21000 32.65800  1.000 85.67864  ? 326 THR F CG2 1 
ATOM   2027 N N   . LYS A 1 292 ? 176.21000 378.18500 30.46500  1.000 82.66348  ? 327 LYS F N   1 
ATOM   2028 C CA  . LYS A 1 292 ? 177.23800 378.74900 29.60100  1.000 86.75296  ? 327 LYS F CA  1 
ATOM   2029 C C   . LYS A 1 292 ? 177.95100 377.58400 28.92400  1.000 92.23876  ? 327 LYS F C   1 
ATOM   2030 O O   . LYS A 1 292 ? 178.55600 376.74000 29.60400  1.000 88.49256  ? 327 LYS F O   1 
ATOM   2031 C CB  . LYS A 1 292 ? 178.20900 379.57900 30.44200  1.000 85.57840  ? 327 LYS F CB  1 
ATOM   2032 C CG  . LYS A 1 292 ? 179.62000 379.74500 29.89500  1.000 89.09843  ? 327 LYS F CG  1 
ATOM   2033 C CD  . LYS A 1 292 ? 180.27800 380.97300 30.52800  1.000 87.43315  ? 327 LYS F CD  1 
ATOM   2034 C CE  . LYS A 1 292 ? 181.66800 381.25200 29.97300  1.000 86.98943  ? 327 LYS F CE  1 
ATOM   2035 N NZ  . LYS A 1 292 ? 181.61800 381.91200 28.63800  1.000 98.60618  ? 327 LYS F NZ  1 
ATOM   2036 N N   . GLU A 1 293 ? 177.83900 377.51600 27.59000  1.000 94.94452  ? 328 GLU F N   1 
ATOM   2037 C CA  . GLU A 1 293 ? 178.47300 376.44000 26.83000  1.000 95.15878  ? 328 GLU F CA  1 
ATOM   2038 C C   . GLU A 1 293 ? 179.98700 376.56000 26.86500  1.000 94.60123  ? 328 GLU F C   1 
ATOM   2039 O O   . GLU A 1 293 ? 180.53500 377.66600 26.79500  1.000 97.62772  ? 328 GLU F O   1 
ATOM   2040 C CB  . GLU A 1 293 ? 178.04800 376.47300 25.36200  1.000 90.24024  ? 328 GLU F CB  1 
ATOM   2041 C CG  . GLU A 1 293 ? 178.40500 377.80900 24.66800  1.000 94.34485  ? 328 GLU F CG  1 
ATOM   2042 C CD  . GLU A 1 293 ? 178.56700 377.68800 23.14000  1.000 82.48054  ? 328 GLU F CD  1 
ATOM   2043 O OE1 . GLU A 1 293 ? 177.80300 376.90900 22.51400  1.000 76.52638  ? 328 GLU F OE1 1 
ATOM   2044 O OE2 . GLU A 1 293 ? 179.45400 378.38900 22.57300  1.000 68.43967  ? 328 GLU F OE2 1 
ATOM   2045 N N   . GLY A 1 294 ? 180.66900 375.41600 27.00300  1.000 81.85901  ? 329 GLY F N   1 
ATOM   2046 C CA  . GLY A 1 294 ? 182.08300 375.45400 27.27700  1.000 81.13908  ? 329 GLY F CA  1 
ATOM   2047 C C   . GLY A 1 294 ? 182.42500 375.32700 28.73700  1.000 82.95586  ? 329 GLY F C   1 
ATOM   2048 O O   . GLY A 1 294 ? 183.61200 375.21300 29.08200  1.000 88.41325  ? 329 GLY F O   1 
ATOM   2049 N N   . SER A 1 295 ? 181.42300 375.32900 29.60700  1.000 72.38558  ? 330 SER F N   1 
ATOM   2050 C CA  . SER A 1 295 ? 181.67100 375.15800 31.02700  1.000 76.14558  ? 330 SER F CA  1 
ATOM   2051 C C   . SER A 1 295 ? 181.07800 373.86300 31.53200  1.000 70.30352  ? 330 SER F C   1 
ATOM   2052 O O   . SER A 1 295 ? 180.95700 373.66600 32.74900  1.000 68.09931  ? 330 SER F O   1 
ATOM   2053 C CB  . SER A 1 295 ? 181.08800 376.33100 31.81300  1.000 78.07025  ? 330 SER F CB  1 
ATOM   2054 O OG  . SER A 1 295 ? 179.67100 376.35700 31.67400  1.000 77.69861  ? 330 SER F OG  1 
ATOM   2055 N N   . ASN A 1 296 ? 180.74500 372.94900 30.63000  1.000 65.92143  ? 331 ASN F N   1 
ATOM   2056 C CA  . ASN A 1 296 ? 180.10900 371.72900 31.07400  1.000 62.59865  ? 331 ASN F CA  1 
ATOM   2057 C C   . ASN A 1 296 ? 181.04400 370.58300 30.75400  1.000 56.51886  ? 331 ASN F C   1 
ATOM   2058 O O   . ASN A 1 296 ? 181.72200 370.59600 29.71700  1.000 56.66240  ? 331 ASN F O   1 
ATOM   2059 C CB  . ASN A 1 296 ? 178.79600 371.51200 30.34000  1.000 53.94692  ? 331 ASN F CB  1 
ATOM   2060 C CG  . ASN A 1 296 ? 177.66300 372.32500 30.94300  1.000 60.01860  ? 331 ASN F CG  1 
ATOM   2061 O OD1 . ASN A 1 296 ? 177.49900 372.38300 32.15900  1.000 54.91593  ? 331 ASN F OD1 1 
ATOM   2062 N ND2 . ASN A 1 296 ? 176.85300 372.93100 30.07600  1.000 55.69999  ? 331 ASN F ND2 1 
ATOM   2063 N N   . ILE A 1 297 ? 181.05000 369.58300 31.62600  1.000 51.81944  ? 332 ILE F N   1 
ATOM   2064 C CA  . ILE A 1 297 ? 181.87200 368.39700 31.42600  1.000 50.63020  ? 332 ILE F CA  1 
ATOM   2065 C C   . ILE A 1 297 ? 180.94500 367.19700 31.43700  1.000 50.40051  ? 332 ILE F C   1 
ATOM   2066 O O   . ILE A 1 297 ? 179.85700 367.23800 32.02800  1.000 46.77667  ? 332 ILE F O   1 
ATOM   2067 C CB  . ILE A 1 297 ? 182.97800 368.24300 32.48400  1.000 44.68451  ? 332 ILE F CB  1 
ATOM   2068 C CG1 . ILE A 1 297 ? 182.34800 368.23900 33.86700  1.000 45.94056  ? 332 ILE F CG1 1 
ATOM   2069 C CG2 . ILE A 1 297 ? 184.06000 369.32700 32.28200  1.000 50.19747  ? 332 ILE F CG2 1 
ATOM   2070 C CD1 . ILE A 1 297 ? 183.32100 368.09000 34.97900  1.000 46.10580  ? 332 ILE F CD1 1 
ATOM   2071 N N   . CYS A 1 298 ? 181.35600 366.14800 30.74900  1.000 45.25478  ? 333 CYS F N   1 
ATOM   2072 C CA  . CYS A 1 298 ? 180.52000 364.98100 30.60500  1.000 39.56345  ? 333 CYS F CA  1 
ATOM   2073 C C   . CYS A 1 298 ? 181.28200 363.69800 30.78600  1.000 43.97620  ? 333 CYS F C   1 
ATOM   2074 O O   . CYS A 1 298 ? 182.47400 363.64000 30.54900  1.000 39.89811  ? 333 CYS F O   1 
ATOM   2075 C CB  . CYS A 1 298 ? 179.92800 364.95600 29.20400  1.000 42.52374  ? 333 CYS F CB  1 
ATOM   2076 S SG  . CYS A 1 298 ? 178.91500 366.32500 28.65500  1.000 45.03944  ? 333 CYS F SG  1 
ATOM   2077 N N   . LEU A 1 299 ? 180.58700 362.66100 31.20500  1.000 39.38194  ? 334 LEU F N   1 
ATOM   2078 C CA  . LEU A 1 299 ? 181.19300 361.36000 31.32200  1.000 39.55156  ? 334 LEU F CA  1 
ATOM   2079 C C   . LEU A 1 299 ? 180.18400 360.31600 30.93700  1.000 39.16874  ? 334 LEU F C   1 
ATOM   2080 O O   . LEU A 1 299 ? 179.00100 360.50600 31.10700  1.000 39.77816  ? 334 LEU F O   1 
ATOM   2081 C CB  . LEU A 1 299 ? 181.72200 361.09500 32.73400  1.000 40.02675  ? 334 LEU F CB  1 
ATOM   2082 C CG  . LEU A 1 299 ? 180.83000 361.02300 33.96700  1.000 42.96856  ? 334 LEU F CG  1 
ATOM   2083 C CD1 . LEU A 1 299 ? 180.14500 359.67200 34.07500  1.000 38.67599  ? 334 LEU F CD1 1 
ATOM   2084 C CD2 . LEU A 1 299 ? 181.69500 361.25900 35.19200  1.000 41.33752  ? 334 LEU F CD2 1 
ATOM   2085 N N   . THR A 1 300 ? 180.65800 359.21400 30.39800  1.000 39.11449  ? 335 THR F N   1 
ATOM   2086 C CA  . THR A 1 300 ? 179.78600 358.12200 30.04600  1.000 36.43316  ? 335 THR F CA  1 
ATOM   2087 C C   . THR A 1 300 ? 180.43200 356.79400 30.37900  1.000 40.51598  ? 335 THR F C   1 
ATOM   2088 O O   . THR A 1 300 ? 181.58100 356.56200 30.04700  1.000 41.19221  ? 335 THR F O   1 
ATOM   2089 C CB  . THR A 1 300 ? 179.40400 358.14500 28.55400  1.000 41.23258  ? 335 THR F CB  1 
ATOM   2090 O OG1 . THR A 1 300 ? 178.98400 359.45800 28.17900  1.000 42.54866  ? 335 THR F OG1 1 
ATOM   2091 C CG2 . THR A 1 300 ? 178.28100 357.16700 28.28000  1.000 38.09841  ? 335 THR F CG2 1 
ATOM   2092 N N   . ARG A 1 301 ? 179.70100 355.92600 31.04900  1.000 33.80400  ? 336 ARG F N   1 
ATOM   2093 C CA  . ARG A 1 301 ? 180.20600 354.58900 31.32300  1.000 38.38168  ? 336 ARG F CA  1 
ATOM   2094 C C   . ARG A 1 301 ? 180.40900 353.85100 30.01500  1.000 40.18780  ? 336 ARG F C   1 
ATOM   2095 O O   . ARG A 1 301 ? 179.55200 353.88000 29.12300  1.000 38.38547  ? 336 ARG F O   1 
ATOM   2096 C CB  . ARG A 1 301 ? 179.25100 353.80500 32.21900  1.000 34.40041  ? 336 ARG F CB  1 
ATOM   2097 C CG  . ARG A 1 301 ? 179.22300 354.32400 33.68300  1.000 37.23370  ? 336 ARG F CG  1 
ATOM   2098 C CD  . ARG A 1 301 ? 178.31600 353.41800 34.44000  1.000 39.86173  ? 336 ARG F CD  1 
ATOM   2099 N NE  . ARG A 1 301 ? 178.81400 352.05600 34.38300  1.000 38.31254  ? 336 ARG F NE  1 
ATOM   2100 C CZ  . ARG A 1 301 ? 178.17700 351.02300 34.89900  1.000 41.76525  ? 336 ARG F CZ  1 
ATOM   2101 N NH1 . ARG A 1 301 ? 176.99800 351.17800 35.49600  1.000 38.42687  ? 336 ARG F NH1 1 
ATOM   2102 N NH2 . ARG A 1 301 ? 178.71400 349.79900 34.78300  1.000 39.10084  ? 336 ARG F NH2 1 
ATOM   2103 N N   . THR A 1 302 ? 181.45100 353.05200 29.96200  1.000 38.68531  ? 337 THR F N   1 
ATOM   2104 C CA  . THR A 1 302 ? 181.70800 352.32900 28.73700  1.000 40.70308  ? 337 THR F CA  1 
ATOM   2105 C C   . THR A 1 302 ? 181.31900 350.86500 28.93900  1.000 39.53408  ? 337 THR F C   1 
ATOM   2106 O O   . THR A 1 302 ? 180.80200 350.45300 29.97900  1.000 41.79901  ? 337 THR F O   1 
ATOM   2107 C CB  . THR A 1 302 ? 183.18000 352.45600 28.34500  1.000 46.75529  ? 337 THR F CB  1 
ATOM   2108 O OG1 . THR A 1 302 ? 183.98200 352.01000 29.41700  1.000 50.05515  ? 337 THR F OG1 1 
ATOM   2109 C CG2 . THR A 1 302 ? 183.54200 353.89700 28.14700  1.000 51.44363  ? 337 THR F CG2 1 
ATOM   2110 N N   . ASP A 1 303 ? 181.49900 350.08400 27.89500  1.000 39.44943  ? 338 ASP F N   1 
ATOM   2111 C CA  . ASP A 1 303 ? 181.18500 348.66100 27.91400  1.000 41.89625  ? 338 ASP F CA  1 
ATOM   2112 C C   . ASP A 1 303 ? 179.70900 348.37900 28.21400  1.000 45.11380  ? 338 ASP F C   1 
ATOM   2113 O O   . ASP A 1 303 ? 179.35100 347.45100 28.94300  1.000 39.50187  ? 338 ASP F O   1 
ATOM   2114 C CB  . ASP A 1 303 ? 182.09100 347.90200 28.89500  1.000 42.67713  ? 338 ASP F CB  1 
ATOM   2115 C CG  . ASP A 1 303 ? 183.57700 347.96800 28.51200  1.000 50.67537  ? 338 ASP F CG  1 
ATOM   2116 O OD1 . ASP A 1 303 ? 183.87400 348.07600 27.29600  1.000 51.72127  ? 338 ASP F OD1 1 
ATOM   2117 O OD2 . ASP A 1 303 ? 184.44900 347.82900 29.40200  1.000 50.99702  ? 338 ASP F OD2 1 
ATOM   2118 N N   . ARG A 1 304 ? 178.87800 348.96600 27.38400  1.000 43.07684  ? 339 ARG F N   1 
ATOM   2119 C CA  . ARG A 1 304 ? 177.46600 348.67600 27.42500  1.000 41.14625  ? 339 ARG F CA  1 
ATOM   2120 C C   . ARG A 1 304 ? 177.24800 347.44300 26.58000  1.000 39.87406  ? 339 ARG F C   1 
ATOM   2121 O O   . ARG A 1 304 ? 178.09600 347.11200 25.75000  1.000 39.84245  ? 339 ARG F O   1 
ATOM   2122 C CB  . ARG A 1 304 ? 176.70300 349.84300 26.80300  1.000 42.63593  ? 339 ARG F CB  1 
ATOM   2123 C CG  . ARG A 1 304 ? 177.06100 350.11900 25.25600  1.000 41.74416  ? 339 ARG F CG  1 
ATOM   2124 C CD  . ARG A 1 304 ? 175.96200 351.04600 24.60600  1.000 40.36111  ? 339 ARG F CD  1 
ATOM   2125 N NE  . ARG A 1 304 ? 176.04000 352.41800 25.11600  1.000 46.76086  ? 339 ARG F NE  1 
ATOM   2126 C CZ  . ARG A 1 304 ? 176.63500 353.48500 24.59200  1.000 54.58035  ? 339 ARG F CZ  1 
ATOM   2127 N NH1 . ARG A 1 304 ? 177.27400 353.42700 23.43500  1.000 49.16847  ? 339 ARG F NH1 1 
ATOM   2128 N NH2 . ARG A 1 304 ? 176.55000 354.66100 25.24300  1.000 46.54555  ? 339 ARG F NH2 1 
ATOM   2129 N N   . GLY A 1 305 ? 176.28000 346.63200 26.97600  1.000 39.49297  ? 340 GLY F N   1 
ATOM   2130 C CA  . GLY A 1 305 ? 175.97000 345.43400 26.21500  1.000 39.65593  ? 340 GLY F CA  1 
ATOM   2131 C C   . GLY A 1 305 ? 175.51900 344.31400 27.13300  1.000 41.18760  ? 340 GLY F C   1 
ATOM   2132 O O   . GLY A 1 305 ? 175.24600 344.53500 28.30800  1.000 37.35101  ? 340 GLY F O   1 
ATOM   2133 N N   . TRP A 1 306 ? 175.70000 343.08800 26.64500  1.000 40.72310  ? 341 TRP F N   1 
ATOM   2134 C CA  . TRP A 1 306 ? 175.26900 341.88800 27.35600  1.000 39.34332  ? 341 TRP F CA  1 
ATOM   2135 C C   . TRP A 1 306 ? 176.42300 341.29700 28.16300  1.000 38.24259  ? 341 TRP F C   1 
ATOM   2136 O O   . TRP A 1 306 ? 177.55100 341.20700 27.66800  1.000 38.12343  ? 341 TRP F O   1 
ATOM   2137 C CB  . TRP A 1 306 ? 174.70900 340.81900 26.40600  1.000 37.68083  ? 341 TRP F CB  1 
ATOM   2138 C CG  . TRP A 1 306 ? 173.29300 341.07200 26.02200  1.000 38.64640  ? 341 TRP F CG  1 
ATOM   2139 C CD1 . TRP A 1 306 ? 172.82500 341.57100 24.83000  1.000 37.43281  ? 341 TRP F CD1 1 
ATOM   2140 C CD2 . TRP A 1 306 ? 172.14800 340.91000 26.86900  1.000 39.36897  ? 341 TRP F CD2 1 
ATOM   2141 N NE1 . TRP A 1 306 ? 171.44600 341.69700 24.88300  1.000 40.65047  ? 341 TRP F NE1 1 
ATOM   2142 C CE2 . TRP A 1 306 ? 171.01100 341.29900 26.12400  1.000 42.96906  ? 341 TRP F CE2 1 
ATOM   2143 C CE3 . TRP A 1 306 ? 171.97500 340.47800 28.18800  1.000 41.70179  ? 341 TRP F CE3 1 
ATOM   2144 C CZ2 . TRP A 1 306 ? 169.71700 341.24400 26.64600  1.000 41.37057  ? 341 TRP F CZ2 1 
ATOM   2145 C CZ3 . TRP A 1 306 ? 170.67600 340.41400 28.71300  1.000 46.66315  ? 341 TRP F CZ3 1 
ATOM   2146 C CH2 . TRP A 1 306 ? 169.56200 340.80800 27.93500  1.000 45.52061  ? 341 TRP F CH2 1 
ATOM   2147 N N   . TYR A 1 307 ? 176.13400 340.96900 29.41800  1.000 39.75709  ? 342 TYR F N   1 
ATOM   2148 C CA  . TYR A 1 307 ? 176.99000 340.26000 30.36100  1.000 37.72570  ? 342 TYR F CA  1 
ATOM   2149 C C   . TYR A 1 307 ? 176.31000 338.98300 30.83300  1.000 42.70787  ? 342 TYR F C   1 
ATOM   2150 O O   . TYR A 1 307 ? 175.14200 339.02500 31.19900  1.000 42.17412  ? 342 TYR F O   1 
ATOM   2151 C CB  . TYR A 1 307 ? 177.26400 341.12000 31.58600  1.000 36.58058  ? 342 TYR F CB  1 
ATOM   2152 C CG  . TYR A 1 307 ? 178.03700 342.36900 31.31200  1.000 39.45254  ? 342 TYR F CG  1 
ATOM   2153 C CD1 . TYR A 1 307 ? 177.43600 343.47700 30.73000  1.000 33.37450  ? 342 TYR F CD1 1 
ATOM   2154 C CD2 . TYR A 1 307 ? 179.38300 342.44900 31.67500  1.000 35.87376  ? 342 TYR F CD2 1 
ATOM   2155 C CE1 . TYR A 1 307 ? 178.17300 344.63200 30.49000  1.000 40.43486  ? 342 TYR F CE1 1 
ATOM   2156 C CE2 . TYR A 1 307 ? 180.12200 343.59600 31.44000  1.000 37.88632  ? 342 TYR F CE2 1 
ATOM   2157 C CZ  . TYR A 1 307 ? 179.50400 344.68400 30.84200  1.000 37.80755  ? 342 TYR F CZ  1 
ATOM   2158 O OH  . TYR A 1 307 ? 180.24200 345.80800 30.60900  1.000 39.27436  ? 342 TYR F OH  1 
ATOM   2159 N N   . CYS A 1 308 ? 177.02200 337.85400 30.83300  1.000 39.21562  ? 343 CYS F N   1 
ATOM   2160 C CA  . CYS A 1 308 ? 176.43300 336.61500 31.33700  1.000 40.14374  ? 343 CYS F CA  1 
ATOM   2161 C C   . CYS A 1 308 ? 177.46900 335.93700 32.22200  1.000 40.21125  ? 343 CYS F C   1 
ATOM   2162 O O   . CYS A 1 308 ? 178.63700 335.84000 31.84900  1.000 36.77362  ? 343 CYS F O   1 
ATOM   2163 C CB  . CYS A 1 308 ? 176.02000 335.63800 30.25400  1.000 42.57094  ? 343 CYS F CB  1 
ATOM   2164 S SG  . CYS A 1 308 ? 174.73800 336.14900 29.05000  1.000 43.53287  ? 343 CYS F SG  1 
ATOM   2165 N N   . ASP A 1 309 ? 177.00900 335.38400 33.34600  1.000 40.89956  ? 344 ASP F N   1 
ATOM   2166 C CA  . ASP A 1 309 ? 177.86900 334.59700 34.22400  1.000 40.11639  ? 344 ASP F CA  1 
ATOM   2167 C C   . ASP A 1 309 ? 178.30200 333.34300 33.48800  1.000 38.40557  ? 344 ASP F C   1 
ATOM   2168 O O   . ASP A 1 309 ? 177.49900 332.73200 32.78800  1.000 37.50947  ? 344 ASP F O   1 
ATOM   2169 C CB  . ASP A 1 309 ? 177.15600 334.20600 35.52100  1.000 42.70472  ? 344 ASP F CB  1 
ATOM   2170 C CG  . ASP A 1 309 ? 176.96000 335.38300 36.46300  1.000 42.76992  ? 344 ASP F CG  1 
ATOM   2171 O OD1 . ASP A 1 309 ? 177.82400 336.26400 36.53400  1.000 44.39540  ? 344 ASP F OD1 1 
ATOM   2172 O OD2 . ASP A 1 309 ? 175.96900 335.38300 37.20700  1.000 49.79179  ? 344 ASP F OD2 1 
ATOM   2173 N N   . ASN A 1 310 ? 179.59400 333.04200 33.53700  1.000 38.08145  ? 345 ASN F N   1 
ATOM   2174 C CA  . ASN A 1 310 ? 180.17700 331.92100 32.79500  1.000 39.74871  ? 345 ASN F CA  1 
ATOM   2175 C C   . ASN A 1 310 ? 181.41600 331.35800 33.47700  1.000 38.70942  ? 345 ASN F C   1 
ATOM   2176 O O   . ASN A 1 310 ? 182.49000 331.97900 33.47600  1.000 36.77605  ? 345 ASN F O   1 
ATOM   2177 C CB  . ASN A 1 310 ? 180.47400 332.36100 31.35500  1.000 36.78711  ? 345 ASN F CB  1 
ATOM   2178 C CG  . ASN A 1 310 ? 180.96400 331.23100 30.47800  1.000 39.17405  ? 345 ASN F CG  1 
ATOM   2179 O OD1 . ASN A 1 310 ? 180.98100 330.07300 30.88100  1.000 40.01664  ? 345 ASN F OD1 1 
ATOM   2180 N ND2 . ASN A 1 310 ? 181.23500 331.55100 29.22100  1.000 37.33427  ? 345 ASN F ND2 1 
ATOM   2181 N N   . ALA A 1 311 ? 181.24700 330.18900 34.10100  1.000 38.96246  ? 346 ALA F N   1 
ATOM   2182 C CA  . ALA A 1 311 ? 182.38400 329.41800 34.60500  1.000 35.55114  ? 346 ALA F CA  1 
ATOM   2183 C C   . ALA A 1 311 ? 183.24800 330.23500 35.56500  1.000 35.70260  ? 346 ALA F C   1 
ATOM   2184 O O   . ALA A 1 311 ? 184.47100 330.23200 35.46700  1.000 40.40811  ? 346 ALA F O   1 
ATOM   2185 C CB  . ALA A 1 311 ? 183.22000 328.91300 33.42800  1.000 30.78011  ? 346 ALA F CB  1 
ATOM   2186 N N   . GLY A 1 312 ? 182.62200 330.85300 36.56600  1.000 32.68097  ? 347 GLY F N   1 
ATOM   2187 C CA  . GLY A 1 312 ? 183.37100 331.62400 37.55400  1.000 34.46838  ? 347 GLY F CA  1 
ATOM   2188 C C   . GLY A 1 312 ? 183.82800 333.01200 37.12000  1.000 39.36182  ? 347 GLY F C   1 
ATOM   2189 O O   . GLY A 1 312 ? 184.37900 333.75000 37.95900  1.000 38.13482  ? 347 GLY F O   1 
ATOM   2190 N N   . SER A 1 313 ? 183.64000 333.38200 35.84200  1.000 36.88875  ? 348 SER F N   1 
ATOM   2191 C CA  . SER A 1 313 ? 183.92800 334.69900 35.27400  1.000 38.62702  ? 348 SER F CA  1 
ATOM   2192 C C   . SER A 1 313 ? 182.65400 335.26200 34.62200  1.000 39.60718  ? 348 SER F C   1 
ATOM   2193 O O   . SER A 1 313 ? 181.56200 334.70500 34.74700  1.000 37.81841  ? 348 SER F O   1 
ATOM   2194 C CB  . SER A 1 313 ? 185.03200 334.66300 34.22100  1.000 37.93641  ? 348 SER F CB  1 
ATOM   2195 O OG  . SER A 1 313 ? 186.26500 334.33900 34.72200  1.000 39.06588  ? 348 SER F OG  1 
ATOM   2196 N N   . VAL A 1 314 ? 182.78600 336.40800 33.95600  1.000 39.11424  ? 349 VAL F N   1 
ATOM   2197 C CA  . VAL A 1 314 ? 181.69200 337.02200 33.21300  1.000 36.04608  ? 349 VAL F CA  1 
ATOM   2198 C C   . VAL A 1 314 ? 182.05400 337.08500 31.72600  1.000 39.39026  ? 349 VAL F C   1 
ATOM   2199 O O   . VAL A 1 314 ? 183.10100 337.63200 31.35600  1.000 40.18013  ? 349 VAL F O   1 
ATOM   2200 C CB  . VAL A 1 314 ? 181.34000 338.40000 33.79900  1.000 37.98326  ? 349 VAL F CB  1 
ATOM   2201 C CG1 . VAL A 1 314 ? 180.27300 339.09800 32.92900  1.000 40.39281  ? 349 VAL F CG1 1 
ATOM   2202 C CG2 . VAL A 1 314 ? 180.80300 338.21100 35.23800  1.000 37.71434  ? 349 VAL F CG2 1 
ATOM   2203 N N   . SER A 1 315 ? 181.18600 336.57600 30.87000  1.000 37.48883  ? 350 SER F N   1 
ATOM   2204 C CA  . SER A 1 315 ? 181.38300 336.69800 29.43000  1.000 37.28080  ? 350 SER F CA  1 
ATOM   2205 C C   . SER A 1 315 ? 180.64600 337.96000 28.98600  1.000 38.98916  ? 350 SER F C   1 
ATOM   2206 O O   . SER A 1 315 ? 179.44200 338.08900 29.22700  1.000 38.22657  ? 350 SER F O   1 
ATOM   2207 C CB  . SER A 1 315 ? 180.83700 335.48200 28.68500  1.000 32.56984  ? 350 SER F CB  1 
ATOM   2208 O OG  . SER A 1 315 ? 181.67800 334.36200 28.85500  1.000 39.52771  ? 350 SER F OG  1 
ATOM   2209 N N   . PHE A 1 316 ? 181.40300 338.94000 28.49300  1.000 37.86461  ? 351 PHE F N   1 
ATOM   2210 C CA  . PHE A 1 316 ? 180.89700 340.21600 27.99100  1.000 36.69781  ? 351 PHE F CA  1 
ATOM   2211 C C   . PHE A 1 316 ? 180.84100 340.24900 26.47100  1.000 40.39217  ? 351 PHE F C   1 
ATOM   2212 O O   . PHE A 1 316 ? 181.81700 339.87800 25.80600  1.000 38.65117  ? 351 PHE F O   1 
ATOM   2213 C CB  . PHE A 1 316 ? 181.76200 341.35300 28.54300  1.000 34.87107  ? 351 PHE F CB  1 
ATOM   2214 C CG  . PHE A 1 316 ? 181.49400 342.69500 27.91100  1.000 41.11086  ? 351 PHE F CG  1 
ATOM   2215 C CD1 . PHE A 1 316 ? 180.23600 343.27100 27.93300  1.000 39.80777  ? 351 PHE F CD1 1 
ATOM   2216 C CD2 . PHE A 1 316 ? 182.55700 343.45200 27.42600  1.000 40.09642  ? 351 PHE F CD2 1 
ATOM   2217 C CE1 . PHE A 1 316 ? 180.01200 344.51600 27.34600  1.000 38.33420  ? 351 PHE F CE1 1 
ATOM   2218 C CE2 . PHE A 1 316 ? 182.35000 344.71300 26.86200  1.000 37.70174  ? 351 PHE F CE2 1 
ATOM   2219 C CZ  . PHE A 1 316 ? 181.07300 345.24800 26.83100  1.000 37.76729  ? 351 PHE F CZ  1 
ATOM   2220 N N   . PHE A 1 317 ? 179.72600 340.74800 25.92900  1.000 35.70530  ? 352 PHE F N   1 
ATOM   2221 C CA  . PHE A 1 317 ? 179.51400 340.83200 24.47500  1.000 40.78807  ? 352 PHE F CA  1 
ATOM   2222 C C   . PHE A 1 317 ? 179.39100 342.29800 24.08500  1.000 42.72521  ? 352 PHE F C   1 
ATOM   2223 O O   . PHE A 1 317 ? 178.29600 342.88200 24.14700  1.000 46.49077  ? 352 PHE F O   1 
ATOM   2224 C CB  . PHE A 1 317 ? 178.27500 340.02700 24.05800  1.000 35.78824  ? 352 PHE F CB  1 
ATOM   2225 C CG  . PHE A 1 317 ? 178.32700 338.61200 24.54500  1.000 42.19990  ? 352 PHE F CG  1 
ATOM   2226 C CD1 . PHE A 1 317 ? 177.82900 338.25600 25.79300  1.000 44.21515  ? 352 PHE F CD1 1 
ATOM   2227 C CD2 . PHE A 1 317 ? 178.90100 337.62800 23.75200  1.000 40.76198  ? 352 PHE F CD2 1 
ATOM   2228 C CE1 . PHE A 1 317 ? 177.90700 336.94700 26.24600  1.000 41.51902  ? 352 PHE F CE1 1 
ATOM   2229 C CE2 . PHE A 1 317 ? 178.99000 336.31900 24.20200  1.000 42.96997  ? 352 PHE F CE2 1 
ATOM   2230 C CZ  . PHE A 1 317 ? 178.47900 335.97900 25.45400  1.000 39.55285  ? 352 PHE F CZ  1 
ATOM   2231 N N   . PRO A 1 318 ? 180.46500 342.89100 23.58100  1.000 41.93630  ? 353 PRO F N   1 
ATOM   2232 C CA  . PRO A 1 318 ? 180.43600 344.33000 23.24500  1.000 45.67430  ? 353 PRO F CA  1 
ATOM   2233 C C   . PRO A 1 318 ? 179.65600 344.64700 21.96700  1.000 52.18390  ? 353 PRO F C   1 
ATOM   2234 O O   . PRO A 1 318 ? 179.01200 345.69900 21.89900  1.000 52.88008  ? 353 PRO F O   1 
ATOM   2235 C CB  . PRO A 1 318 ? 181.92100 344.69800 23.14400  1.000 38.22731  ? 353 PRO F CB  1 
ATOM   2236 C CG  . PRO A 1 318 ? 182.60700 343.37400 22.76700  1.000 40.93533  ? 353 PRO F CG  1 
ATOM   2237 C CD  . PRO A 1 318 ? 181.80800 342.29100 23.45800  1.000 38.50780  ? 353 PRO F CD  1 
ATOM   2238 N N   . GLN A 1 319 ? 179.73900 343.79800 20.94000  1.000 53.69916  ? 354 GLN F N   1 
ATOM   2239 C CA  . GLN A 1 319 ? 179.03300 344.03700 19.68400  1.000 61.01696  ? 354 GLN F CA  1 
ATOM   2240 C C   . GLN A 1 319 ? 177.52400 343.86200 19.86300  1.000 60.40210  ? 354 GLN F C   1 
ATOM   2241 O O   . GLN A 1 319 ? 177.06300 342.90800 20.49300  1.000 60.47402  ? 354 GLN F O   1 
ATOM   2242 C CB  . GLN A 1 319 ? 179.53800 343.04400 18.62800  1.000 59.80592  ? 354 GLN F CB  1 
ATOM   2243 C CG  . GLN A 1 319 ? 180.89100 343.37100 17.98800  1.000 67.50688  ? 354 GLN F CG  1 
ATOM   2244 C CD  . GLN A 1 319 ? 181.19500 344.86300 17.90300  1.000 78.03098  ? 354 GLN F CD  1 
ATOM   2245 O OE1 . GLN A 1 319 ? 181.62800 345.48000 18.88300  1.000 77.82424  ? 354 GLN F OE1 1 
ATOM   2246 N NE2 . GLN A 1 319 ? 181.00000 345.44500 16.71900  1.000 81.33202  ? 354 GLN F NE2 1 
ATOM   2247 N N   . ALA A 1 320 ? 176.73900 344.71000 19.18800  1.000 67.19129  ? 355 ALA F N   1 
ATOM   2248 C CA  . ALA A 1 320 ? 175.29200 344.71400 19.43100  1.000 68.76037  ? 355 ALA F CA  1 
ATOM   2249 C C   . ALA A 1 320 ? 174.56900 343.57100 18.73100  1.000 64.02315  ? 355 ALA F C   1 
ATOM   2250 O O   . ALA A 1 320 ? 173.53400 343.10200 19.20700  1.000 71.72384  ? 355 ALA F O   1 
ATOM   2251 C CB  . ALA A 1 320 ? 174.68800 346.05100 19.00200  1.000 64.71168  ? 355 ALA F CB  1 
ATOM   2252 N N   . GLU A 1 321 ? 175.06900 343.13200 17.60300  1.000 70.19501  ? 356 GLU F N   1 
ATOM   2253 C CA  . GLU A 1 321 ? 174.42800 342.09200 16.81100  1.000 74.97475  ? 356 GLU F CA  1 
ATOM   2254 C C   . GLU A 1 321 ? 174.82700 340.66100 17.17900  1.000 69.91455  ? 356 GLU F C   1 
ATOM   2255 O O   . GLU A 1 321 ? 174.27900 339.71700 16.59600  1.000 74.16924  ? 356 GLU F O   1 
ATOM   2256 C CB  . GLU A 1 321 ? 174.74700 342.33600 15.33200  1.000 77.10228  ? 356 GLU F CB  1 
ATOM   2257 C CG  . GLU A 1 321 ? 176.23800 342.09300 15.02000  1.000 80.37611  ? 356 GLU F CG  1 
ATOM   2258 C CD  . GLU A 1 321 ? 177.19900 343.23700 15.48900  1.000 84.55738  ? 356 GLU F CD  1 
ATOM   2259 O OE1 . GLU A 1 321 ? 176.74900 344.26700 16.06600  1.000 83.56987  ? 356 GLU F OE1 1 
ATOM   2260 O OE2 . GLU A 1 321 ? 178.43300 343.06100 15.35900  1.000 82.05404  ? 356 GLU F OE2 1 
ATOM   2261 N N   . THR A 1 322 ? 175.70500 340.46300 18.15700  1.000 65.09726  ? 357 THR F N   1 
ATOM   2262 C CA  . THR A 1 322 ? 176.14400 339.12100 18.52900  1.000 60.19706  ? 357 THR F CA  1 
ATOM   2263 C C   . THR A 1 322 ? 175.23700 338.36000 19.49500  1.000 61.20951  ? 357 THR F C   1 
ATOM   2264 O O   . THR A 1 322 ? 175.49300 337.16800 19.70700  1.000 66.50264  ? 357 THR F O   1 
ATOM   2265 C CB  . THR A 1 322 ? 177.55500 339.20600 19.12100  1.000 58.00939  ? 357 THR F CB  1 
ATOM   2266 O OG1 . THR A 1 322 ? 177.86000 337.99700 19.84100  1.000 64.43642  ? 357 THR F OG1 1 
ATOM   2267 C CG2 . THR A 1 322 ? 177.65300 340.36900 20.04600  1.000 59.51285  ? 357 THR F CG2 1 
ATOM   2268 N N   . CYS A 1 323 ? 174.12300 338.91500 19.96100  1.000 51.44498  ? 358 CYS F N   1 
ATOM   2269 C CA  . CYS A 1 323 ? 173.25200 338.20200 20.89700  1.000 49.19486  ? 358 CYS F CA  1 
ATOM   2270 C C   . CYS A 1 323 ? 171.79800 338.34500 20.48100  1.000 51.99213  ? 358 CYS F C   1 
ATOM   2271 O O   . CYS A 1 323 ? 171.31400 339.45900 20.28000  1.000 54.35103  ? 358 CYS F O   1 
ATOM   2272 C CB  . CYS A 1 323 ? 173.42000 338.70400 22.34200  1.000 44.45300  ? 358 CYS F CB  1 
ATOM   2273 S SG  . CYS A 1 323 ? 174.98600 338.26900 23.16600  1.000 46.34818  ? 358 CYS F SG  1 
ATOM   2274 N N   . LYS A 1 324 ? 171.15600 337.22200 20.20500  1.000 53.63492  ? 359 LYS F N   1 
ATOM   2275 C CA  . LYS A 1 324 ? 169.74000 337.20300 19.88200  1.000 47.36109  ? 359 LYS F CA  1 
ATOM   2276 C C   . LYS A 1 324 ? 168.94800 336.89000 21.14400  1.000 53.66994  ? 359 LYS F C   1 
ATOM   2277 O O   . LYS A 1 324 ? 169.31300 335.98500 21.90300  1.000 51.49074  ? 359 LYS F O   1 
ATOM   2278 C CB  . LYS A 1 324 ? 169.45700 336.13000 18.83200  1.000 51.25498  ? 359 LYS F CB  1 
ATOM   2279 C CG  . LYS A 1 324 ? 170.35600 336.26400 17.61600  1.000 55.55123  ? 359 LYS F CG  1 
ATOM   2280 C CD  . LYS A 1 324 ? 169.85700 337.17900 16.53500  1.000 62.25903  ? 359 LYS F CD  1 
ATOM   2281 C CE  . LYS A 1 324 ? 171.04800 337.92200 15.91500  1.000 65.79769  ? 359 LYS F CE  1 
ATOM   2282 N NZ  . LYS A 1 324 ? 172.34600 337.14500 15.89400  1.000 70.12168  ? 359 LYS F NZ  1 
ATOM   2283 N N   . VAL A 1 325 ? 167.85800 337.61500 21.38700  1.000 51.04791  ? 360 VAL F N   1 
ATOM   2284 C CA  . VAL A 1 325 ? 167.09700 337.39700 22.60800  1.000 51.87330  ? 360 VAL F CA  1 
ATOM   2285 C C   . VAL A 1 325 ? 165.74200 336.83200 22.19800  1.000 60.06575  ? 360 VAL F C   1 
ATOM   2286 O O   . VAL A 1 325 ? 165.04700 337.41600 21.36000  1.000 63.36965  ? 360 VAL F O   1 
ATOM   2287 C CB  . VAL A 1 325 ? 166.95400 338.71500 23.38200  1.000 50.24332  ? 360 VAL F CB  1 
ATOM   2288 C CG1 . VAL A 1 325 ? 166.22900 338.50400 24.68900  1.000 52.95880  ? 360 VAL F CG1 1 
ATOM   2289 C CG2 . VAL A 1 325 ? 168.31100 339.27800 23.63300  1.000 51.47418  ? 360 VAL F CG2 1 
ATOM   2290 N N   . GLN A 1 326 ? 165.33700 335.74300 22.85500  1.000 56.98330  ? 361 GLN F N   1 
ATOM   2291 C CA  . GLN A 1 326 ? 164.01800 335.12300 22.73500  1.000 61.19602  ? 361 GLN F CA  1 
ATOM   2292 C C   . GLN A 1 326 ? 163.43800 334.90200 24.11400  1.000 61.11301  ? 361 GLN F C   1 
ATOM   2293 O O   . GLN A 1 326 ? 164.00100 334.13800 24.90500  1.000 63.22194  ? 361 GLN F O   1 
ATOM   2294 C CB  . GLN A 1 326 ? 164.04200 333.79000 21.98000  1.000 68.65932  ? 361 GLN F CB  1 
ATOM   2295 C CG  . GLN A 1 326 ? 162.76000 333.53600 21.15400  1.000 80.37426  ? 361 GLN F CG  1 
ATOM   2296 C CD  . GLN A 1 326 ? 162.97400 332.62800 19.92900  1.000 84.48390  ? 361 GLN F CD  1 
ATOM   2297 O OE1 . GLN A 1 326 ? 162.67300 331.43100 19.97000  1.000 80.54815  ? 361 GLN F OE1 1 
ATOM   2298 N NE2 . GLN A 1 326 ? 163.51700 333.18400 18.85600  1.000 82.44793  ? 361 GLN F NE2 1 
ATOM   2299 N N   . SER A 1 327 ? 162.34500 335.57900 24.41900  1.000 65.16281  ? 362 SER F N   1 
ATOM   2300 C CA  . SER A 1 327 ? 161.75300 335.40300 25.73300  1.000 67.93070  ? 362 SER F CA  1 
ATOM   2301 C C   . SER A 1 327 ? 162.70200 336.08200 26.70100  1.000 71.00690  ? 362 SER F C   1 
ATOM   2302 O O   . SER A 1 327 ? 163.09000 337.24000 26.50500  1.000 73.99030  ? 362 SER F O   1 
ATOM   2303 C CB  . SER A 1 327 ? 161.57300 333.92300 26.10400  1.000 66.21338  ? 362 SER F CB  1 
ATOM   2304 O OG  . SER A 1 327 ? 160.87200 333.19100 25.11300  1.000 68.32445  ? 362 SER F OG  1 
ATOM   2305 N N   . ASN A 1 328 ? 163.13500 335.35600 27.71800  1.000 65.92934  ? 363 ASN F N   1 
ATOM   2306 C CA  . ASN A 1 328 ? 164.14500 335.88000 28.61400  1.000 60.52823  ? 363 ASN F CA  1 
ATOM   2307 C C   . ASN A 1 328 ? 165.47300 335.15100 28.45000  1.000 49.29808  ? 363 ASN F C   1 
ATOM   2308 O O   . ASN A 1 328 ? 166.28700 335.14600 29.36800  1.000 47.24810  ? 363 ASN F O   1 
ATOM   2309 C CB  . ASN A 1 328 ? 163.60000 335.79700 30.03100  1.000 63.36301  ? 363 ASN F CB  1 
ATOM   2310 C CG  . ASN A 1 328 ? 162.08500 335.96400 30.05000  1.000 78.71544  ? 363 ASN F CG  1 
ATOM   2311 O OD1 . ASN A 1 328 ? 161.34200 334.99000 30.24300  1.000 85.69376  ? 363 ASN F OD1 1 
ATOM   2312 N ND2 . ASN A 1 328 ? 161.61400 337.19200 29.77400  1.000 73.31063  ? 363 ASN F ND2 1 
ATOM   2313 N N   . ARG A 1 329 ? 165.68900 334.52900 27.29500  1.000 45.95270  ? 364 ARG F N   1 
ATOM   2314 C CA  . ARG A 1 329 ? 166.89900 333.78100 27.00300  1.000 52.45493  ? 364 ARG F CA  1 
ATOM   2315 C C   . ARG A 1 329 ? 167.75300 334.53700 25.98600  1.000 52.04961  ? 364 ARG F C   1 
ATOM   2316 O O   . ARG A 1 329 ? 167.24300 334.96200 24.93900  1.000 51.60951  ? 364 ARG F O   1 
ATOM   2317 C CB  . ARG A 1 329 ? 166.55500 332.38100 26.47600  1.000 51.09222  ? 364 ARG F CB  1 
ATOM   2318 C CG  . ARG A 1 329 ? 167.80400 331.48400 26.32700  1.000 50.57562  ? 364 ARG F CG  1 
ATOM   2319 C CD  . ARG A 1 329 ? 167.46400 330.00800 26.27000  1.000 54.17589  ? 364 ARG F CD  1 
ATOM   2320 N NE  . ARG A 1 329 ? 166.64000 329.59200 27.40200  1.000 55.20067  ? 364 ARG F NE  1 
ATOM   2321 C CZ  . ARG A 1 329 ? 167.11200 329.15500 28.56000  1.000 55.66735  ? 364 ARG F CZ  1 
ATOM   2322 N NH1 . ARG A 1 329 ? 168.41400 329.09200 28.79600  1.000 54.20163  ? 364 ARG F NH1 1 
ATOM   2323 N NH2 . ARG A 1 329 ? 166.25700 328.76500 29.50400  1.000 51.74765  ? 364 ARG F NH2 1 
ATOM   2324 N N   . VAL A 1 330 ? 169.05400 334.70300 26.29700  1.000 43.58016  ? 365 VAL F N   1 
ATOM   2325 C CA  . VAL A 1 330 ? 170.03100 335.31600 25.38500  1.000 45.23072  ? 365 VAL F CA  1 
ATOM   2326 C C   . VAL A 1 330 ? 170.83700 334.20400 24.73400  1.000 41.76737  ? 365 VAL F C   1 
ATOM   2327 O O   . VAL A 1 330 ? 171.53400 333.48400 25.44000  1.000 47.55546  ? 365 VAL F O   1 
ATOM   2328 C CB  . VAL A 1 330 ? 170.95100 336.26400 26.19200  1.000 44.02642  ? 365 VAL F CB  1 
ATOM   2329 C CG1 . VAL A 1 330 ? 171.72600 337.24500 25.31200  1.000 44.36714  ? 365 VAL F CG1 1 
ATOM   2330 C CG2 . VAL A 1 330 ? 170.11100 337.02900 27.20300  1.000 42.62976  ? 365 VAL F CG2 1 
ATOM   2331 N N   . PHE A 1 331 ? 171.03600 334.29400 23.42400  1.000 43.85176  ? 366 PHE F N   1 
ATOM   2332 C CA  . PHE A 1 331 ? 171.77600 333.30900 22.64200  1.000 43.57469  ? 366 PHE F CA  1 
ATOM   2333 C C   . PHE A 1 331 ? 172.93500 334.06000 22.02300  1.000 45.22895  ? 366 PHE F C   1 
ATOM   2334 O O   . PHE A 1 331 ? 172.73200 334.94400 21.18700  1.000 46.65463  ? 366 PHE F O   1 
ATOM   2335 C CB  . PHE A 1 331 ? 170.92900 332.68500 21.53100  1.000 46.19969  ? 366 PHE F CB  1 
ATOM   2336 C CG  . PHE A 1 331 ? 169.83600 331.77700 21.99500  1.000 44.79479  ? 366 PHE F CG  1 
ATOM   2337 C CD1 . PHE A 1 331 ? 168.63100 332.27900 22.42400  1.000 46.00778  ? 366 PHE F CD1 1 
ATOM   2338 C CD2 . PHE A 1 331 ? 169.97400 330.39900 21.85700  1.000 41.57511  ? 366 PHE F CD2 1 
ATOM   2339 C CE1 . PHE A 1 331 ? 167.61200 331.42300 22.82800  1.000 48.72724  ? 366 PHE F CE1 1 
ATOM   2340 C CE2 . PHE A 1 331 ? 168.96300 329.54800 22.23700  1.000 44.47227  ? 366 PHE F CE2 1 
ATOM   2341 C CZ  . PHE A 1 331 ? 167.78000 330.05300 22.74200  1.000 40.46124  ? 366 PHE F CZ  1 
ATOM   2342 N N   . CYS A 1 332 ? 174.10000 333.83100 22.59700  1.000 38.71000  ? 367 CYS F N   1 
ATOM   2343 C CA  . CYS A 1 332 ? 175.32800 334.48400 22.19600  1.000 43.48898  ? 367 CYS F CA  1 
ATOM   2344 C C   . CYS A 1 332 ? 176.32700 333.45400 21.67300  1.000 46.02490  ? 367 CYS F C   1 
ATOM   2345 O O   . CYS A 1 332 ? 176.32500 332.30000 22.10200  1.000 45.29644  ? 367 CYS F O   1 
ATOM   2346 C CB  . CYS A 1 332 ? 175.91000 335.23100 23.39100  1.000 42.51122  ? 367 CYS F CB  1 
ATOM   2347 S SG  . CYS A 1 332 ? 174.73800 336.41800 24.02800  1.000 49.37940  ? 367 CYS F SG  1 
ATOM   2348 N N   . ASP A 1 333 ? 177.32600 333.92900 20.95700  1.000 40.40767  ? 368 ASP F N   1 
ATOM   2349 C CA  . ASP A 1 333 ? 178.42400 333.10600 20.46900  1.000 45.79184  ? 368 ASP F CA  1 
ATOM   2350 C C   . ASP A 1 333 ? 179.60600 333.63100 21.26000  1.000 43.48508  ? 368 ASP F C   1 
ATOM   2351 O O   . ASP A 1 333 ? 179.90500 334.82600 21.21800  1.000 44.60034  ? 368 ASP F O   1 
ATOM   2352 C CB  . ASP A 1 333 ? 178.65800 333.24700 18.95600  1.000 43.40428  ? 368 ASP F CB  1 
ATOM   2353 C CG  . ASP A 1 333 ? 179.59700 332.17500 18.39100  1.000 47.31692  ? 368 ASP F CG  1 
ATOM   2354 O OD1 . ASP A 1 333 ? 180.60900 331.85100 19.07100  1.000 46.24178  ? 368 ASP F OD1 1 
ATOM   2355 O OD2 . ASP A 1 333 ? 179.37500 331.65700 17.28200  1.000 56.59425  ? 368 ASP F OD2 1 
ATOM   2356 N N   . THR A 1 334 ? 180.28500 332.73400 21.94600  1.000 42.24627  ? 369 THR F N   1 
ATOM   2357 C CA  . THR A 1 334 ? 181.41300 333.10200 22.79300  1.000 47.91517  ? 369 THR F CA  1 
ATOM   2358 C C   . THR A 1 334 ? 182.62300 333.59800 22.02900  1.000 44.07404  ? 369 THR F C   1 
ATOM   2359 O O   . THR A 1 334 ? 183.51200 334.18800 22.60400  1.000 44.57075  ? 369 THR F O   1 
ATOM   2360 C CB  . THR A 1 334 ? 181.82500 331.89900 23.66600  1.000 42.32447  ? 369 THR F CB  1 
ATOM   2361 O OG1 . THR A 1 334 ? 182.07700 330.76300 22.83500  1.000 43.27014  ? 369 THR F OG1 1 
ATOM   2362 C CG2 . THR A 1 334 ? 180.73200 331.56800 24.66100  1.000 42.20879  ? 369 THR F CG2 1 
ATOM   2363 N N   . MET A 1 335 ? 182.64400 333.36900 20.73500  1.000 42.15460  ? 370 MET F N   1 
ATOM   2364 C CA  . MET A 1 335 ? 183.74200 333.82100 19.91000  1.000 46.87089  ? 370 MET F CA  1 
ATOM   2365 C C   . MET A 1 335 ? 183.82100 335.31300 19.88100  1.000 51.79835  ? 370 MET F C   1 
ATOM   2366 O O   . MET A 1 335 ? 184.88100 335.88200 19.70200  1.000 54.59757  ? 370 MET F O   1 
ATOM   2367 C CB  . MET A 1 335 ? 183.54900 333.33100 18.50300  1.000 47.55069  ? 370 MET F CB  1 
ATOM   2368 C CG  . MET A 1 335 ? 184.84700 333.15600 17.75500  1.000 68.24071  ? 370 MET F CG  1 
ATOM   2369 S SD  . MET A 1 335 ? 185.12100 331.45300 17.25700  1.000 86.88036  ? 370 MET F SD  1 
ATOM   2370 C CE  . MET A 1 335 ? 186.05100 331.76500 15.77000  1.000 71.44269  ? 370 MET F CE  1 
ATOM   2371 N N   . ASN A 1 336 ? 182.69100 335.95100 20.06000  1.000 46.98042  ? 371 ASN F N   1 
ATOM   2372 C CA  . ASN A 1 336 ? 182.66300 337.38200 20.09500  1.000 55.39207  ? 371 ASN F CA  1 
ATOM   2373 C C   . ASN A 1 336 ? 182.49100 337.89700 21.51000  1.000 51.13739  ? 371 ASN F C   1 
ATOM   2374 O O   . ASN A 1 336 ? 181.63600 338.73400 21.75100  1.000 51.44772  ? 371 ASN F O   1 
ATOM   2375 C CB  . ASN A 1 336 ? 181.49700 337.85200 19.24100  1.000 56.35607  ? 371 ASN F CB  1 
ATOM   2376 C CG  . ASN A 1 336 ? 181.36400 337.07000 17.95300  1.000 64.45289  ? 371 ASN F CG  1 
ATOM   2377 O OD1 . ASN A 1 336 ? 180.41000 336.32100 17.76700  1.000 65.72071  ? 371 ASN F OD1 1 
ATOM   2378 N ND2 . ASN A 1 336 ? 182.32200 337.24400 17.05500  1.000 63.36600  ? 371 ASN F ND2 1 
ATOM   2379 N N   . SER A 1 337 ? 183.29600 337.42700 22.45300  1.000 44.84792  ? 372 SER F N   1 
ATOM   2380 C CA  . SER A 1 337 ? 183.05300 337.83300 23.82800  1.000 41.50374  ? 372 SER F CA  1 
ATOM   2381 C C   . SER A 1 337 ? 184.41400 338.18500 24.39600  1.000 38.98323  ? 372 SER F C   1 
ATOM   2382 O O   . SER A 1 337 ? 185.45300 337.86600 23.82700  1.000 40.61345  ? 372 SER F O   1 
ATOM   2383 C CB  . SER A 1 337 ? 182.38500 336.74800 24.69300  1.000 41.48181  ? 372 SER F CB  1 
ATOM   2384 O OG  . SER A 1 337 ? 183.20300 335.57700 24.82500  1.000 38.62502  ? 372 SER F OG  1 
ATOM   2385 N N   . LEU A 1 338 ? 184.40500 338.83900 25.52000  1.000 40.15355  ? 373 LEU F N   1 
ATOM   2386 C CA  . LEU A 1 338 ? 185.59300 339.03000 26.31900  1.000 40.38248  ? 373 LEU F CA  1 
ATOM   2387 C C   . LEU A 1 338 ? 185.27600 338.40500 27.66000  1.000 38.67314  ? 373 LEU F C   1 
ATOM   2388 O O   . LEU A 1 338 ? 184.12100 338.38100 28.07500  1.000 35.86909  ? 373 LEU F O   1 
ATOM   2389 C CB  . LEU A 1 338 ? 185.95500 340.51300 26.44100  1.000 34.70357  ? 373 LEU F CB  1 
ATOM   2390 C CG  . LEU A 1 338 ? 186.14800 341.25000 25.07800  1.000 48.25504  ? 373 LEU F CG  1 
ATOM   2391 C CD1 . LEU A 1 338 ? 186.16200 342.78400 25.20900  1.000 37.34312  ? 373 LEU F CD1 1 
ATOM   2392 C CD2 . LEU A 1 338 ? 187.43200 340.81900 24.41400  1.000 40.53473  ? 373 LEU F CD2 1 
ATOM   2393 N N   . THR A 1 339 ? 186.27800 337.84000 28.29700  1.000 37.76429  ? 374 THR F N   1 
ATOM   2394 C CA  . THR A 1 339 ? 186.12200 337.19800 29.59500  1.000 39.51649  ? 374 THR F CA  1 
ATOM   2395 C C   . THR A 1 339 ? 186.59500 338.18400 30.63800  1.000 37.79610  ? 374 THR F C   1 
ATOM   2396 O O   . THR A 1 339 ? 187.76000 338.56400 30.63000  1.000 34.73182  ? 374 THR F O   1 
ATOM   2397 C CB  . THR A 1 339 ? 186.90800 335.89400 29.66200  1.000 41.57671  ? 374 THR F CB  1 
ATOM   2398 O OG1 . THR A 1 339 ? 186.46200 335.06200 28.59100  1.000 36.99582  ? 374 THR F OG1 1 
ATOM   2399 C CG2 . THR A 1 339 ? 186.68700 335.18700 31.00300  1.000 31.76445  ? 374 THR F CG2 1 
ATOM   2400 N N   . LEU A 1 340 ? 185.70500 338.57100 31.54600  1.000 33.98616  ? 375 LEU F N   1 
ATOM   2401 C CA  . LEU A 1 340 ? 186.02700 339.55100 32.55300  1.000 39.25736  ? 375 LEU F CA  1 
ATOM   2402 C C   . LEU A 1 340 ? 185.86300 338.96100 33.94700  1.000 40.73075  ? 375 LEU F C   1 
ATOM   2403 O O   . LEU A 1 340 ? 185.10100 338.00200 34.13800  1.000 41.98847  ? 375 LEU F O   1 
ATOM   2404 C CB  . LEU A 1 340 ? 185.09500 340.77700 32.41600  1.000 39.32540  ? 375 LEU F CB  1 
ATOM   2405 C CG  . LEU A 1 340 ? 185.04400 341.45800 31.03800  1.000 38.21940  ? 375 LEU F CG  1 
ATOM   2406 C CD1 . LEU A 1 340 ? 184.04700 342.62800 31.04900  1.000 38.97317  ? 375 LEU F CD1 1 
ATOM   2407 C CD2 . LEU A 1 340 ? 186.43500 341.88900 30.54800  1.000 37.17692  ? 375 LEU F CD2 1 
ATOM   2408 N N   . PRO A 1 341 ? 186.59500 339.47600 34.93100  1.000 40.73263  ? 376 PRO F N   1 
ATOM   2409 C CA  . PRO A 1 341 ? 186.37000 339.02000 36.31500  1.000 40.92245  ? 376 PRO F CA  1 
ATOM   2410 C C   . PRO A 1 341 ? 184.96900 339.39000 36.75700  1.000 41.33224  ? 376 PRO F C   1 
ATOM   2411 O O   . PRO A 1 341 ? 184.40200 340.38400 36.31000  1.000 43.08095  ? 376 PRO F O   1 
ATOM   2412 C CB  . PRO A 1 341 ? 187.42900 339.78500 37.13100  1.000 40.29110  ? 376 PRO F CB  1 
ATOM   2413 C CG  . PRO A 1 341 ? 187.78100 341.05400 36.22800  1.000 43.02170  ? 376 PRO F CG  1 
ATOM   2414 C CD  . PRO A 1 341 ? 187.65200 340.51000 34.81100  1.000 38.82534  ? 376 PRO F CD  1 
ATOM   2415 N N   . SER A 1 342 ? 184.40400 338.58000 37.65600  1.000 41.20911  ? 377 SER F N   1 
ATOM   2416 C CA  . SER A 1 342 ? 183.04400 338.83800 38.12200  1.000 40.42751  ? 377 SER F CA  1 
ATOM   2417 C C   . SER A 1 342 ? 182.94200 340.16200 38.85300  1.000 42.04658  ? 377 SER F C   1 
ATOM   2418 O O   . SER A 1 342 ? 181.84000 340.72700 38.95000  1.000 41.31559  ? 377 SER F O   1 
ATOM   2419 C CB  . SER A 1 342 ? 182.56800 337.72600 39.06600  1.000 41.14029  ? 377 SER F CB  1 
ATOM   2420 O OG  . SER A 1 342 ? 183.43700 337.66600 40.19800  1.000 48.73132  ? 377 SER F OG  1 
ATOM   2421 N N   . GLU A 1 343 ? 184.07800 340.74600 39.22700  1.000 41.69831  ? 378 GLU F N   1 
ATOM   2422 C CA  . GLU A 1 343 ? 184.02400 342.03000 39.90200  1.000 45.47446  ? 378 GLU F CA  1 
ATOM   2423 C C   . GLU A 1 343 ? 183.60300 343.14700 38.95100  1.000 42.06722  ? 378 GLU F C   1 
ATOM   2424 O O   . GLU A 1 343 ? 183.36200 344.25600 39.41200  1.000 44.72510  ? 378 GLU F O   1 
ATOM   2425 C CB  . GLU A 1 343 ? 185.37000 342.40500 40.54400  1.000 42.14429  ? 378 GLU F CB  1 
ATOM   2426 C CG  . GLU A 1 343 ? 185.80700 341.63600 41.80900  1.000 47.07271  ? 378 GLU F CG  1 
ATOM   2427 C CD  . GLU A 1 343 ? 186.13300 340.15700 41.57500  1.000 47.55606  ? 378 GLU F CD  1 
ATOM   2428 O OE1 . GLU A 1 343 ? 186.68900 339.80600 40.51600  1.000 45.40169  ? 378 GLU F OE1 1 
ATOM   2429 O OE2 . GLU A 1 343 ? 185.86900 339.34800 42.47600  1.000 54.57338  ? 378 GLU F OE2 1 
ATOM   2430 N N   . VAL A 1 344 ? 183.47600 342.87200 37.65300  1.000 41.64924  ? 379 VAL F N   1 
ATOM   2431 C CA  . VAL A 1 344 ? 183.04800 343.91600 36.74000  1.000 43.66664  ? 379 VAL F CA  1 
ATOM   2432 C C   . VAL A 1 344 ? 181.61900 344.30800 37.08200  1.000 46.21816  ? 379 VAL F C   1 
ATOM   2433 O O   . VAL A 1 344 ? 181.25200 345.48000 36.95500  1.000 39.57817  ? 379 VAL F O   1 
ATOM   2434 C CB  . VAL A 1 344 ? 183.14700 343.47400 35.26700  1.000 42.70869  ? 379 VAL F CB  1 
ATOM   2435 C CG1 . VAL A 1 344 ? 182.05500 342.44100 34.92200  1.000 38.08402  ? 379 VAL F CG1 1 
ATOM   2436 C CG2 . VAL A 1 344 ? 182.92600 344.70900 34.35900  1.000 39.62291  ? 379 VAL F CG2 1 
ATOM   2437 N N   . ASN A 1 345 ? 180.84900 343.45800 37.72300  1.000 40.95237  ? 380 ASN F N   1 
ATOM   2438 C CA  . ASN A 1 345 ? 179.51600 343.88000 38.12500  1.000 42.89132  ? 380 ASN F CA  1 
ATOM   2439 C C   . ASN A 1 345 ? 179.47500 345.00200 39.15900  1.000 48.60247  ? 380 ASN F C   1 
ATOM   2440 O O   . ASN A 1 345 ? 178.45200 345.62900 39.34100  1.000 51.24638  ? 380 ASN F O   1 
ATOM   2441 C CB  . ASN A 1 345 ? 178.70200 342.70400 38.64800  1.000 42.29534  ? 380 ASN F CB  1 
ATOM   2442 C CG  . ASN A 1 345 ? 177.25600 343.07100 38.90600  1.000 55.62460  ? 380 ASN F CG  1 
ATOM   2443 O OD1 . ASN A 1 345 ? 176.55700 343.54500 38.01600  1.000 50.77107  ? 380 ASN F OD1 1 
ATOM   2444 N ND2 . ASN A 1 345 ? 176.80600 342.86800 40.13200  1.000 51.49456  ? 380 ASN F ND2 1 
ATOM   2445 N N   . LEU A 1 346 ? 180.57900 345.26400 39.82300  1.000 44.66469  ? 381 LEU F N   1 
ATOM   2446 C CA  . LEU A 1 346 ? 180.59100 346.27800 40.85500  1.000 49.87403  ? 381 LEU F CA  1 
ATOM   2447 C C   . LEU A 1 346 ? 180.47000 347.67500 40.28100  1.000 50.45315  ? 381 LEU F C   1 
ATOM   2448 O O   . LEU A 1 346 ? 180.13400 348.60300 40.99100  1.000 48.23341  ? 381 LEU F O   1 
ATOM   2449 C CB  . LEU A 1 346 ? 181.85500 346.16000 41.70500  1.000 48.83297  ? 381 LEU F CB  1 
ATOM   2450 C CG  . LEU A 1 346 ? 182.05000 344.87000 42.50000  1.000 52.68311  ? 381 LEU F CG  1 
ATOM   2451 C CD1 . LEU A 1 346 ? 183.39800 344.86800 43.19500  1.000 49.28119  ? 381 LEU F CD1 1 
ATOM   2452 C CD2 . LEU A 1 346 ? 180.92400 344.67500 43.49900  1.000 47.30207  ? 381 LEU F CD2 1 
ATOM   2453 N N   . CYS A 1 347 ? 180.73500 347.82200 38.99800  1.000 45.14199  ? 382 CYS F N   1 
ATOM   2454 C CA  . CYS A 1 347 ? 180.57900 349.10500 38.35600  1.000 47.14080  ? 382 CYS F CA  1 
ATOM   2455 C C   . CYS A 1 347 ? 179.10100 349.44500 38.34900  1.000 46.25495  ? 382 CYS F C   1 
ATOM   2456 O O   . CYS A 1 347 ? 178.73800 350.58700 38.15600  1.000 46.98733  ? 382 CYS F O   1 
ATOM   2457 C CB  . CYS A 1 347 ? 181.21400 349.08400 36.97000  1.000 41.68566  ? 382 CYS F CB  1 
ATOM   2458 S SG  . CYS A 1 347 ? 182.99200 348.80800 36.96100  1.000 51.33237  ? 382 CYS F SG  1 
ATOM   2459 N N   . ASN A 1 348 ? 178.25200 348.45800 38.57200  1.000 45.35949  ? 383 ASN F N   1 
ATOM   2460 C CA  . ASN A 1 348 ? 176.83900 348.72100 38.71000  1.000 44.54378  ? 383 ASN F CA  1 
ATOM   2461 C C   . ASN A 1 348 ? 176.42200 349.05800 40.13600  1.000 51.27766  ? 383 ASN F C   1 
ATOM   2462 O O   . ASN A 1 348 ? 175.31300 349.55700 40.31800  1.000 55.66203  ? 383 ASN F O   1 
ATOM   2463 C CB  . ASN A 1 348 ? 175.99400 347.63100 38.08800  1.000 45.54580  ? 383 ASN F CB  1 
ATOM   2464 C CG  . ASN A 1 348 ? 176.47000 347.33100 36.72000  1.000 43.13267  ? 383 ASN F CG  1 
ATOM   2465 O OD1 . ASN A 1 348 ? 176.38000 348.19100 35.83700  1.000 45.47669  ? 383 ASN F OD1 1 
ATOM   2466 N ND2 . ASN A 1 348 ? 176.72600 346.06700 36.45700  1.000 38.72034  ? 383 ASN F ND2 1 
ATOM   2467 N N   . VAL A 1 349 ? 177.15200 348.65400 41.17600  1.000 51.34334  ? 384 VAL F N   1 
ATOM   2468 C CA  . VAL A 1 349 ? 176.71500 349.01600 42.51000  1.000 51.60843  ? 384 VAL F CA  1 
ATOM   2469 C C   . VAL A 1 349 ? 177.57800 350.10500 43.15600  1.000 50.67658  ? 384 VAL F C   1 
ATOM   2470 O O   . VAL A 1 349 ? 177.04400 350.93500 43.89900  1.000 57.88660  ? 384 VAL F O   1 
ATOM   2471 C CB  . VAL A 1 349 ? 176.67700 347.75400 43.40200  1.000 58.86598  ? 384 VAL F CB  1 
ATOM   2472 C CG1 . VAL A 1 349 ? 176.28300 346.52600 42.59300  1.000 49.37535  ? 384 VAL F CG1 1 
ATOM   2473 C CG2 . VAL A 1 349 ? 177.97900 347.55500 44.13300  1.000 52.00097  ? 384 VAL F CG2 1 
ATOM   2474 N N   . ASP A 1 350 ? 178.87300 350.15500 42.85400  1.000 51.98575  ? 385 ASP F N   1 
ATOM   2475 C CA  . ASP A 1 350 ? 179.83300 351.13100 43.38400  1.000 52.24158  ? 385 ASP F CA  1 
ATOM   2476 C C   . ASP A 1 350 ? 180.85600 351.43400 42.29300  1.000 51.92221  ? 385 ASP F C   1 
ATOM   2477 O O   . ASP A 1 350 ? 181.84900 350.71200 42.20100  1.000 54.30913  ? 385 ASP F O   1 
ATOM   2478 C CB  . ASP A 1 350 ? 180.48900 350.68600 44.68700  1.000 56.71346  ? 385 ASP F CB  1 
ATOM   2479 C CG  . ASP A 1 350 ? 181.47200 351.72500 45.22700  1.000 56.14557  ? 385 ASP F CG  1 
ATOM   2480 O OD1 . ASP A 1 350 ? 181.36900 352.92600 44.86400  1.000 57.29759  ? 385 ASP F OD1 1 
ATOM   2481 O OD2 . ASP A 1 350 ? 182.33500 351.35100 46.04900  1.000 65.95871  ? 385 ASP F OD2 1 
ATOM   2482 N N   . ILE A 1 351 ? 180.73500 352.55900 41.58600  1.000 50.73542  ? 386 ILE F N   1 
ATOM   2483 C CA  . ILE A 1 351 ? 181.66200 352.72400 40.46400  1.000 48.87328  ? 386 ILE F CA  1 
ATOM   2484 C C   . ILE A 1 351 ? 183.03400 353.17100 40.93700  1.000 50.90112  ? 386 ILE F C   1 
ATOM   2485 O O   . ILE A 1 351 ? 184.00500 353.05800 40.17200  1.000 50.33008  ? 386 ILE F O   1 
ATOM   2486 C CB  . ILE A 1 351 ? 181.05800 353.69900 39.43200  1.000 49.27110  ? 386 ILE F CB  1 
ATOM   2487 C CG1 . ILE A 1 351 ? 181.84300 353.66800 38.12700  1.000 47.40282  ? 386 ILE F CG1 1 
ATOM   2488 C CG2 . ILE A 1 351 ? 181.02400 355.12200 39.95800  1.000 49.30306  ? 386 ILE F CG2 1 
ATOM   2489 C CD1 . ILE A 1 351 ? 181.24000 354.52300 37.05100  1.000 50.31787  ? 386 ILE F CD1 1 
ATOM   2490 N N   . PHE A 1 352 ? 183.11800 353.74300 42.13500  1.000 49.29658  ? 387 PHE F N   1 
ATOM   2491 C CA  . PHE A 1 352 ? 184.32100 354.24000 42.79900  1.000 54.64051  ? 387 PHE F CA  1 
ATOM   2492 C C   . PHE A 1 352 ? 185.02900 353.12400 43.58900  1.000 59.33780  ? 387 PHE F C   1 
ATOM   2493 O O   . PHE A 1 352 ? 186.09500 353.36600 44.16100  1.000 62.01776  ? 387 PHE F O   1 
ATOM   2494 C CB  . PHE A 1 352 ? 183.94800 355.39900 43.71000  1.000 51.11862  ? 387 PHE F CB  1 
ATOM   2495 C CG  . PHE A 1 352 ? 183.62300 356.63900 42.95700  1.000 52.46502  ? 387 PHE F CG  1 
ATOM   2496 C CD1 . PHE A 1 352 ? 184.44400 357.06600 41.92500  1.000 51.27776  ? 387 PHE F CD1 1 
ATOM   2497 C CD2 . PHE A 1 352 ? 182.40700 357.25600 43.13800  1.000 46.54875  ? 387 PHE F CD2 1 
ATOM   2498 C CE1 . PHE A 1 352 ? 184.13300 358.19100 41.18600  1.000 51.80956  ? 387 PHE F CE1 1 
ATOM   2499 C CE2 . PHE A 1 352 ? 182.07600 358.37300 42.38100  1.000 52.17617  ? 387 PHE F CE2 1 
ATOM   2500 C CZ  . PHE A 1 352 ? 182.94600 358.83600 41.40300  1.000 46.14656  ? 387 PHE F CZ  1 
ATOM   2501 N N   . ASN A 1 353 ? 184.61600 351.88800 43.37500  1.000 54.90907  ? 388 ASN F N   1 
ATOM   2502 C CA  . ASN A 1 353 ? 185.05300 350.69800 44.10000  1.000 57.44364  ? 388 ASN F CA  1 
ATOM   2503 C C   . ASN A 1 353 ? 186.38100 350.14200 43.60000  1.000 59.82353  ? 388 ASN F C   1 
ATOM   2504 O O   . ASN A 1 353 ? 186.57400 350.01500 42.39000  1.000 64.66986  ? 388 ASN F O   1 
ATOM   2505 C CB  . ASN A 1 353 ? 183.96100 349.65800 43.94600  1.000 60.54940  ? 388 ASN F CB  1 
ATOM   2506 C CG  . ASN A 1 353 ? 184.47100 348.26900 44.06300  1.000 71.37194  ? 388 ASN F CG  1 
ATOM   2507 O OD1 . ASN A 1 353 ? 185.04500 347.73000 43.08900  1.000 59.51996  ? 388 ASN F OD1 1 
ATOM   2508 N ND2 . ASN A 1 353 ? 184.28500 347.65100 45.25400  1.000 77.40250  ? 388 ASN F ND2 1 
ATOM   2509 N N   . PRO A 1 354 ? 187.37600 349.98900 44.48700  1.000 63.97229  ? 389 PRO F N   1 
ATOM   2510 C CA  . PRO A 1 354 ? 188.69300 349.49300 44.06800  1.000 63.58235  ? 389 PRO F CA  1 
ATOM   2511 C C   . PRO A 1 354 ? 188.80200 348.04400 43.64300  1.000 61.26604  ? 389 PRO F C   1 
ATOM   2512 O O   . PRO A 1 354 ? 189.90700 347.67200 43.23600  1.000 68.49064  ? 389 PRO F O   1 
ATOM   2513 C CB  . PRO A 1 354 ? 189.53100 349.70100 45.32900  1.000 62.00581  ? 389 PRO F CB  1 
ATOM   2514 C CG  . PRO A 1 354 ? 188.54100 349.29500 46.44300  1.000 62.91970  ? 389 PRO F CG  1 
ATOM   2515 C CD  . PRO A 1 354 ? 187.12000 349.63700 45.89600  1.000 63.49256  ? 389 PRO F CD  1 
ATOM   2516 N N   . LYS A 1 355 ? 187.81900 347.16100 43.80400  1.000 58.13788  ? 390 LYS F N   1 
ATOM   2517 C CA  . LYS A 1 355 ? 188.18300 345.84100 43.30400  1.000 58.24396  ? 390 LYS F CA  1 
ATOM   2518 C C   . LYS A 1 355 ? 188.25200 345.80600 41.76700  1.000 59.99553  ? 390 LYS F C   1 
ATOM   2519 O O   . LYS A 1 355 ? 189.07100 345.07100 41.20200  1.000 55.29650  ? 390 LYS F O   1 
ATOM   2520 C CB  . LYS A 1 355 ? 187.18000 344.81500 43.81400  1.000 52.63311  ? 390 LYS F CB  1 
ATOM   2521 C CG  . LYS A 1 355 ? 187.23200 344.62200 45.33200  1.000 58.64324  ? 390 LYS F CG  1 
ATOM   2522 C CD  . LYS A 1 355 ? 186.21000 343.60600 45.79900  1.000 64.81621  ? 390 LYS F CD  1 
ATOM   2523 C CE  . LYS A 1 355 ? 186.89200 342.30300 46.15500  1.000 73.15741  ? 390 LYS F CE  1 
ATOM   2524 N NZ  . LYS A 1 355 ? 185.93000 341.27000 46.61600  1.000 74.69177  ? 390 LYS F NZ  1 
ATOM   2525 N N   . TYR A 1 356 ? 187.47000 346.64200 41.06900  1.000 54.01570  ? 391 TYR F N   1 
ATOM   2526 C CA  . TYR A 1 356 ? 187.53400 346.69400 39.61200  1.000 49.15053  ? 391 TYR F CA  1 
ATOM   2527 C C   . TYR A 1 356 ? 187.56400 348.13800 39.12000  1.000 48.75414  ? 391 TYR F C   1 
ATOM   2528 O O   . TYR A 1 356 ? 186.75900 348.95800 39.57200  1.000 49.76529  ? 391 TYR F O   1 
ATOM   2529 C CB  . TYR A 1 356 ? 186.36400 345.90100 38.99400  1.000 45.60959  ? 391 TYR F CB  1 
ATOM   2530 C CG  . TYR A 1 356 ? 186.36900 345.87400 37.45800  1.000 50.52198  ? 391 TYR F CG  1 
ATOM   2531 C CD1 . TYR A 1 356 ? 185.85200 346.94100 36.72100  1.000 45.22934  ? 391 TYR F CD1 1 
ATOM   2532 C CD2 . TYR A 1 356 ? 186.92100 344.80600 36.74900  1.000 42.06911  ? 391 TYR F CD2 1 
ATOM   2533 C CE1 . TYR A 1 356 ? 185.87400 346.93000 35.33100  1.000 47.53052  ? 391 TYR F CE1 1 
ATOM   2534 C CE2 . TYR A 1 356 ? 186.93000 344.78800 35.34500  1.000 40.86336  ? 391 TYR F CE2 1 
ATOM   2535 C CZ  . TYR A 1 356 ? 186.40600 345.86000 34.64800  1.000 46.08965  ? 391 TYR F CZ  1 
ATOM   2536 O OH  . TYR A 1 356 ? 186.40700 345.89000 33.26200  1.000 51.65268  ? 391 TYR F OH  1 
ATOM   2537 N N   . ASP A 1 357 ? 188.48200 348.45400 38.21500  1.000 45.93084  ? 392 ASP F N   1 
ATOM   2538 C CA  . ASP A 1 357 ? 188.62300 349.81700 37.69100  1.000 50.52375  ? 392 ASP F CA  1 
ATOM   2539 C C   . ASP A 1 357 ? 187.56700 350.15600 36.62100  1.000 44.63145  ? 392 ASP F C   1 
ATOM   2540 O O   . ASP A 1 357 ? 187.82300 350.10000 35.42500  1.000 48.99594  ? 392 ASP F O   1 
ATOM   2541 C CB  . ASP A 1 357 ? 190.02500 350.03400 37.16800  1.000 53.16986  ? 392 ASP F CB  1 
ATOM   2542 C CG  . ASP A 1 357 ? 190.34900 351.49700 37.05300  1.000 58.77829  ? 392 ASP F CG  1 
ATOM   2543 O OD1 . ASP A 1 357 ? 189.67100 352.31300 37.75700  1.000 52.49157  ? 392 ASP F OD1 1 
ATOM   2544 O OD2 . ASP A 1 357 ? 191.26300 351.80900 36.25100  1.000 58.44728  ? 392 ASP F OD2 1 
ATOM   2545 N N   . CYS A 1 358 ? 186.37500 350.54300 37.05900  1.000 49.55849  ? 393 CYS F N   1 
ATOM   2546 C CA  . CYS A 1 358 ? 185.25200 351.04700 36.25300  1.000 50.90484  ? 393 CYS F CA  1 
ATOM   2547 C C   . CYS A 1 358 ? 185.60800 352.02600 35.14300  1.000 44.11669  ? 393 CYS F C   1 
ATOM   2548 O O   . CYS A 1 358 ? 186.29700 353.01000 35.39700  1.000 53.71379  ? 393 CYS F O   1 
ATOM   2549 C CB  . CYS A 1 358 ? 184.14300 351.57600 37.12700  1.000 48.01846  ? 393 CYS F CB  1 
ATOM   2550 S SG  . CYS A 1 358 ? 183.71600 350.24700 38.19100  1.000 49.14236  ? 393 CYS F SG  1 
ATOM   2551 N N   . LYS A 1 359 ? 185.40500 351.63800 33.90100  1.000 43.09038  ? 394 LYS F N   1 
ATOM   2552 C CA  . LYS A 1 359 ? 185.89900 352.42000 32.78400  1.000 52.90849  ? 394 LYS F CA  1 
ATOM   2553 C C   . LYS A 1 359 ? 184.84000 353.44000 32.33500  1.000 49.92836  ? 394 LYS F C   1 
ATOM   2554 O O   . LYS A 1 359 ? 183.63000 353.18700 32.37900  1.000 45.65463  ? 394 LYS F O   1 
ATOM   2555 C CB  . LYS A 1 359 ? 186.16600 351.38700 31.67200  1.000 58.20512  ? 394 LYS F CB  1 
ATOM   2556 C CG  . LYS A 1 359 ? 187.26000 350.35200 32.13700  1.000 58.18559  ? 394 LYS F CG  1 
ATOM   2557 C CD  . LYS A 1 359 ? 187.52800 349.08600 31.27100  1.000 59.39355  ? 394 LYS F CD  1 
ATOM   2558 C CE  . LYS A 1 359 ? 187.24300 349.18900 29.78000  1.000 70.78434  ? 394 LYS F CE  1 
ATOM   2559 N NZ  . LYS A 1 359 ? 187.68500 350.46600 29.19100  1.000 68.30809  ? 394 LYS F NZ  1 
ATOM   2560 N N   . ILE A 1 360 ? 185.31000 354.61800 31.94700  1.000 42.82068  ? 395 ILE F N   1 
ATOM   2561 C CA  . ILE A 1 360 ? 184.47200 355.70900 31.46000  1.000 47.35034  ? 395 ILE F CA  1 
ATOM   2562 C C   . ILE A 1 360 ? 185.15600 356.38400 30.28600  1.000 45.47577  ? 395 ILE F C   1 
ATOM   2563 O O   . ILE A 1 360 ? 186.37600 356.34600 30.15200  1.000 41.79713  ? 395 ILE F O   1 
ATOM   2564 C CB  . ILE A 1 360 ? 184.13000 356.71600 32.58100  1.000 46.97721  ? 395 ILE F CB  1 
ATOM   2565 C CG1 . ILE A 1 360 ? 185.42800 357.34400 33.09800  1.000 47.10926  ? 395 ILE F CG1 1 
ATOM   2566 C CG2 . ILE A 1 360 ? 183.19700 356.11700 33.63700  1.000 42.71181  ? 395 ILE F CG2 1 
ATOM   2567 C CD1 . ILE A 1 360 ? 185.23200 358.56400 33.90000  1.000 52.44289  ? 395 ILE F CD1 1 
ATOM   2568 N N   . MET A 1 361 ? 184.37800 357.20200 29.57900  1.000 42.93049  ? 396 MET F N   1 
ATOM   2569 C CA  . MET A 1 361 ? 184.88300 358.10400 28.55900  1.000 40.88363  ? 396 MET F CA  1 
ATOM   2570 C C   . MET A 1 361 ? 184.35800 359.48200 28.90200  1.000 43.39269  ? 396 MET F C   1 
ATOM   2571 O O   . MET A 1 361 ? 183.32200 359.60500 29.55500  1.000 45.38416  ? 396 MET F O   1 
ATOM   2572 C CB  . MET A 1 361 ? 184.47800 357.72400 27.10200  1.000 41.30120  ? 396 MET F CB  1 
ATOM   2573 C CG  . MET A 1 361 ? 183.00300 357.69300 26.83800  1.000 52.64826  ? 396 MET F CG  1 
ATOM   2574 S SD  . MET A 1 361 ? 182.62800 358.50200 25.24400  1.000 83.29505  ? 396 MET F SD  1 
ATOM   2575 C CE  . MET A 1 361 ? 183.22600 360.15200 25.58600  1.000 47.35289  ? 396 MET F CE  1 
ATOM   2576 N N   . THR A 1 362 ? 185.14200 360.51200 28.59100  1.000 40.66914  ? 397 THR F N   1 
ATOM   2577 C CA  . THR A 1 362 ? 184.77400 361.87300 28.95700  1.000 41.08491  ? 397 THR F CA  1 
ATOM   2578 C C   . THR A 1 362 ? 184.69800 362.74900 27.71100  1.000 44.80877  ? 397 THR F C   1 
ATOM   2579 O O   . THR A 1 362 ? 185.19000 362.40500 26.63600  1.000 43.76228  ? 397 THR F O   1 
ATOM   2580 C CB  . THR A 1 362 ? 185.76500 362.49500 29.94000  1.000 42.15827  ? 397 THR F CB  1 
ATOM   2581 O OG1 . THR A 1 362 ? 187.06500 362.58000 29.34300  1.000 39.67515  ? 397 THR F OG1 1 
ATOM   2582 C CG2 . THR A 1 362 ? 185.86400 361.56600 31.17400  1.000 36.47942  ? 397 THR F CG2 1 
ATOM   2583 N N   . SER A 1 363 ? 183.95400 363.82000 27.82200  1.000 48.79535  ? 398 SER F N   1 
ATOM   2584 C CA  . SER A 1 363 ? 183.88100 364.73600 26.69600  1.000 50.70103  ? 398 SER F CA  1 
ATOM   2585 C C   . SER A 1 363 ? 183.20600 366.01300 27.15700  1.000 56.13578  ? 398 SER F C   1 
ATOM   2586 O O   . SER A 1 363 ? 182.97100 366.22900 28.35300  1.000 54.95072  ? 398 SER F O   1 
ATOM   2587 C CB  . SER A 1 363 ? 183.11600 364.14100 25.52900  1.000 55.08835  ? 398 SER F CB  1 
ATOM   2588 O OG  . SER A 1 363 ? 181.76300 364.10100 25.86000  1.000 55.02707  ? 398 SER F OG  1 
ATOM   2589 N N   . LYS A 1 364 ? 182.99100 366.89700 26.19500  1.000 54.30884  ? 399 LYS F N   1 
ATOM   2590 C CA  . LYS A 1 364 ? 182.19900 368.09900 26.38800  1.000 55.14719  ? 399 LYS F CA  1 
ATOM   2591 C C   . LYS A 1 364 ? 181.05300 368.09600 25.37400  1.000 60.79296  ? 399 LYS F C   1 
ATOM   2592 O O   . LYS A 1 364 ? 180.58000 369.15600 24.93700  1.000 61.16633  ? 399 LYS F O   1 
ATOM   2593 C CB  . LYS A 1 364 ? 183.05000 369.36200 26.29800  1.000 58.20887  ? 399 LYS F CB  1 
ATOM   2594 C CG  . LYS A 1 364 ? 184.11400 369.42800 27.39400  1.000 60.32069  ? 399 LYS F CG  1 
ATOM   2595 C CD  . LYS A 1 364 ? 185.06400 370.57700 27.18400  1.000 62.64339  ? 399 LYS F CD  1 
ATOM   2596 C CE  . LYS A 1 364 ? 184.37300 371.91500 27.35900  1.000 72.86509  ? 399 LYS F CE  1 
ATOM   2597 N NZ  . LYS A 1 364 ? 183.93200 372.09700 28.77500  1.000 68.34951  ? 399 LYS F NZ  1 
ATOM   2598 N N   . THR A 1 365 ? 180.59700 366.90100 24.95300  1.000 57.55684  ? 400 THR F N   1 
ATOM   2599 C CA  . THR A 1 365 ? 179.56200 366.87200 23.92600  1.000 63.23379  ? 400 THR F CA  1 
ATOM   2600 C C   . THR A 1 365 ? 178.25500 366.56600 24.63600  1.000 56.27537  ? 400 THR F C   1 
ATOM   2601 O O   . THR A 1 365 ? 177.84900 365.41400 24.78400  1.000 58.86380  ? 400 THR F O   1 
ATOM   2602 C CB  . THR A 1 365 ? 179.83500 365.86100 22.81700  1.000 66.44808  ? 400 THR F CB  1 
ATOM   2603 O OG1 . THR A 1 365 ? 181.12300 366.08800 22.23700  1.000 66.11756  ? 400 THR F OG1 1 
ATOM   2604 C CG2 . THR A 1 365 ? 178.71200 365.93200 21.72400  1.000 67.31547  ? 400 THR F CG2 1 
ATOM   2605 N N   . ASP A 1 366 ? 177.56200 367.63200 25.02200  1.000 53.45313  ? 401 ASP F N   1 
ATOM   2606 C CA  . ASP A 1 366 ? 176.29400 367.50200 25.72500  1.000 57.84787  ? 401 ASP F CA  1 
ATOM   2607 C C   . ASP A 1 366 ? 175.20300 367.63000 24.65900  1.000 58.89790  ? 401 ASP F C   1 
ATOM   2608 O O   . ASP A 1 366 ? 174.55200 368.67100 24.50900  1.000 64.00897  ? 401 ASP F O   1 
ATOM   2609 C CB  . ASP A 1 366 ? 176.17500 368.54800 26.84800  1.000 55.50199  ? 401 ASP F CB  1 
ATOM   2610 C CG  . ASP A 1 366 ? 176.46300 369.99100 26.37300  1.000 60.73747  ? 401 ASP F CG  1 
ATOM   2611 O OD1 . ASP A 1 366 ? 177.18300 370.21700 25.37100  1.000 63.32242  ? 401 ASP F OD1 1 
ATOM   2612 O OD2 . ASP A 1 366 ? 176.07800 370.90800 27.11700  1.000 63.34268  ? 401 ASP F OD2 1 
ATOM   2613 N N   . VAL A 1 367 ? 174.98300 366.54300 23.92300  1.000 54.51276  ? 402 VAL F N   1 
ATOM   2614 C CA  . VAL A 1 367 ? 173.91900 366.48300 22.92800  1.000 49.93467  ? 402 VAL F CA  1 
ATOM   2615 C C   . VAL A 1 367 ? 172.89300 365.56100 23.55600  1.000 43.70211  ? 402 VAL F C   1 
ATOM   2616 O O   . VAL A 1 367 ? 173.26100 364.60200 24.23700  1.000 48.80298  ? 402 VAL F O   1 
ATOM   2617 C CB  . VAL A 1 367 ? 174.37300 365.97500 21.54600  1.000 54.48871  ? 402 VAL F CB  1 
ATOM   2618 C CG1 . VAL A 1 367 ? 174.73900 364.50500 21.62200  1.000 54.74786  ? 402 VAL F CG1 1 
ATOM   2619 C CG2 . VAL A 1 367 ? 173.25400 366.14000 20.53600  1.000 47.38783  ? 402 VAL F CG2 1 
ATOM   2620 N N   . SER A 1 368 ? 171.62600 365.93200 23.45800  1.000 38.80874  ? 403 SER F N   1 
ATOM   2621 C CA  . SER A 1 368 ? 170.57600 365.16200 24.10700  1.000 41.90452  ? 403 SER F CA  1 
ATOM   2622 C C   . SER A 1 368 ? 170.38300 363.83600 23.39500  1.000 40.28360  ? 403 SER F C   1 
ATOM   2623 O O   . SER A 1 368 ? 170.55400 363.73600 22.18100  1.000 40.87095  ? 403 SER F O   1 
ATOM   2624 C CB  . SER A 1 368 ? 169.27100 365.96500 24.09000  1.000 34.05271  ? 403 SER F CB  1 
ATOM   2625 O OG  . SER A 1 368 ? 169.45700 367.13600 24.85300  1.000 37.47102  ? 403 SER F OG  1 
ATOM   2626 N N   . SER A 1 369 ? 169.99900 362.81500 24.15800  1.000 39.62114  ? 404 SER F N   1 
ATOM   2627 C CA  . SER A 1 369 ? 169.75400 361.49400 23.58700  1.000 39.81243  ? 404 SER F CA  1 
ATOM   2628 C C   . SER A 1 369 ? 168.93600 360.67800 24.56600  1.000 41.34395  ? 404 SER F C   1 
ATOM   2629 O O   . SER A 1 369 ? 168.76100 361.04800 25.72400  1.000 42.57484  ? 404 SER F O   1 
ATOM   2630 C CB  . SER A 1 369 ? 171.04600 360.77700 23.21000  1.000 34.64694  ? 404 SER F CB  1 
ATOM   2631 O OG  . SER A 1 369 ? 171.83200 360.63200 24.36400  1.000 48.21285  ? 404 SER F OG  1 
ATOM   2632 N N   . SER A 1 370 ? 168.46300 359.53500 24.08600  1.000 45.63861  ? 405 SER F N   1 
ATOM   2633 C CA  . SER A 1 370 ? 167.70900 358.60800 24.89500  1.000 40.94558  ? 405 SER F CA  1 
ATOM   2634 C C   . SER A 1 370 ? 168.10100 357.18500 24.54900  1.000 43.32999  ? 405 SER F C   1 
ATOM   2635 O O   . SER A 1 370 ? 168.50300 356.89800 23.42100  1.000 44.10061  ? 405 SER F O   1 
ATOM   2636 C CB  . SER A 1 370 ? 166.21100 358.77000 24.67100  1.000 43.82960  ? 405 SER F CB  1 
ATOM   2637 O OG  . SER A 1 370 ? 165.50700 357.83900 25.49700  1.000 44.33729  ? 405 SER F OG  1 
ATOM   2638 N N   . VAL A 1 371 ? 167.94700 356.29500 25.52700  1.000 40.59427  ? 406 VAL F N   1 
ATOM   2639 C CA  . VAL A 1 371 ? 168.22900 354.87900 25.35100  1.000 42.82681  ? 406 VAL F CA  1 
ATOM   2640 C C   . VAL A 1 371 ? 166.99400 354.15100 25.82300  1.000 37.81891  ? 406 VAL F C   1 
ATOM   2641 O O   . VAL A 1 371 ? 166.59300 354.30100 26.97800  1.000 42.30820  ? 406 VAL F O   1 
ATOM   2642 C CB  . VAL A 1 371 ? 169.44700 354.40200 26.17200  1.000 39.36762  ? 406 VAL F CB  1 
ATOM   2643 C CG1 . VAL A 1 371 ? 169.63700 352.91100 25.96300  1.000 41.98735  ? 406 VAL F CG1 1 
ATOM   2644 C CG2 . VAL A 1 371 ? 170.68800 355.13600 25.75900  1.000 41.36367  ? 406 VAL F CG2 1 
ATOM   2645 N N   . ILE A 1 372 ? 166.39400 353.36700 24.93700  1.000 36.23321  ? 407 ILE F N   1 
ATOM   2646 C CA  . ILE A 1 372 ? 165.24200 352.54000 25.28000  1.000 40.47239  ? 407 ILE F CA  1 
ATOM   2647 C C   . ILE A 1 372 ? 165.77400 351.26600 25.94200  1.000 40.92303  ? 407 ILE F C   1 
ATOM   2648 O O   . ILE A 1 372 ? 166.52400 350.51500 25.32200  1.000 48.03851  ? 407 ILE F O   1 
ATOM   2649 C CB  . ILE A 1 372 ? 164.41300 352.21700 24.02600  1.000 41.69993  ? 407 ILE F CB  1 
ATOM   2650 C CG1 . ILE A 1 372 ? 163.85500 353.51700 23.42100  1.000 41.55603  ? 407 ILE F CG1 1 
ATOM   2651 C CG2 . ILE A 1 372 ? 163.26800 351.26900 24.38000  1.000 45.30101  ? 407 ILE F CG2 1 
ATOM   2652 C CD1 . ILE A 1 372 ? 162.97300 354.31600 24.37700  1.000 38.08403  ? 407 ILE F CD1 1 
ATOM   2653 N N   . THR A 1 373 ? 165.44900 351.05000 27.21400  1.000 38.99228  ? 408 THR F N   1 
ATOM   2654 C CA  . THR A 1 373 ? 165.91900 349.87400 27.94400  1.000 42.89302  ? 408 THR F CA  1 
ATOM   2655 C C   . THR A 1 373 ? 164.87700 348.75300 27.87700  1.000 45.90823  ? 408 THR F C   1 
ATOM   2656 O O   . THR A 1 373 ? 163.94300 348.78600 27.06500  1.000 45.41829  ? 408 THR F O   1 
ATOM   2657 C CB  . THR A 1 373 ? 166.24600 350.23000 29.38500  1.000 41.01659  ? 408 THR F CB  1 
ATOM   2658 O OG1 . THR A 1 373 ? 165.02300 350.52900 30.06900  1.000 40.94222  ? 408 THR F OG1 1 
ATOM   2659 C CG2 . THR A 1 373 ? 167.19200 351.45000 29.44500  1.000 43.86863  ? 408 THR F CG2 1 
ATOM   2660 N N   . SER A 1 374 ? 165.04600 347.71100 28.69800  1.000 43.90527  ? 409 SER F N   1 
ATOM   2661 C CA  . SER A 1 374 ? 164.06900 346.62600 28.64900  1.000 45.50294  ? 409 SER F CA  1 
ATOM   2662 C C   . SER A 1 374 ? 162.75300 347.03400 29.30500  1.000 45.79190  ? 409 SER F C   1 
ATOM   2663 O O   . SER A 1 374 ? 161.68200 346.67100 28.81300  1.000 44.41050  ? 409 SER F O   1 
ATOM   2664 C CB  . SER A 1 374 ? 164.57200 345.37200 29.36400  1.000 46.28962  ? 409 SER F CB  1 
ATOM   2665 O OG  . SER A 1 374 ? 165.81800 344.93200 28.91700  1.000 55.71057  ? 409 SER F OG  1 
ATOM   2666 N N   . LEU A 1 375 ? 162.80600 347.87200 30.34300  1.000 42.60390  ? 410 LEU F N   1 
ATOM   2667 C CA  . LEU A 1 375 ? 161.59500 348.22300 31.07100  1.000 50.24105  ? 410 LEU F CA  1 
ATOM   2668 C C   . LEU A 1 375 ? 161.36100 349.72200 31.19500  1.000 49.88493  ? 410 LEU F C   1 
ATOM   2669 O O   . LEU A 1 375 ? 160.54000 350.13700 32.01500  1.000 50.52307  ? 410 LEU F O   1 
ATOM   2670 C CB  . LEU A 1 375 ? 161.64300 347.63100 32.48200  1.000 41.57048  ? 410 LEU F CB  1 
ATOM   2671 C CG  . LEU A 1 375 ? 161.74500 346.10700 32.54100  1.000 48.61656  ? 410 LEU F CG  1 
ATOM   2672 C CD1 . LEU A 1 375 ? 161.85900 345.67200 34.00700  1.000 47.94647  ? 410 LEU F CD1 1 
ATOM   2673 C CD2 . LEU A 1 375 ? 160.60400 345.42500 31.78300  1.000 55.73740  ? 410 LEU F CD2 1 
ATOM   2674 N N   . GLY A 1 376 ? 162.02700 350.54000 30.39000  1.000 45.76624  ? 411 GLY F N   1 
ATOM   2675 C CA  . GLY A 1 376 ? 161.84900 351.96200 30.51700  1.000 41.87847  ? 411 GLY F CA  1 
ATOM   2676 C C   . GLY A 1 376 ? 162.69900 352.71500 29.52700  1.000 40.97332  ? 411 GLY F C   1 
ATOM   2677 O O   . GLY A 1 376 ? 162.83200 352.28700 28.38500  1.000 38.54276  ? 411 GLY F O   1 
ATOM   2678 N N   . ALA A 1 377 ? 163.20900 353.87300 29.92000  1.000 37.84227  ? 412 ALA F N   1 
ATOM   2679 C CA  . ALA A 1 377 ? 164.00400 354.68100 29.00300  1.000 42.06182  ? 412 ALA F CA  1 
ATOM   2680 C C   . ALA A 1 377 ? 164.87400 355.61200 29.81500  1.000 40.76469  ? 412 ALA F C   1 
ATOM   2681 O O   . ALA A 1 377 ? 164.39800 356.19900 30.79600  1.000 38.29248  ? 412 ALA F O   1 
ATOM   2682 C CB  . ALA A 1 377 ? 163.13200 355.50200 28.04600  1.000 36.48451  ? 412 ALA F CB  1 
ATOM   2683 N N   . ILE A 1 378 ? 166.16200 355.66900 29.46200  1.000 39.89728  ? 413 ILE F N   1 
ATOM   2684 C CA  . ILE A 1 378 ? 167.07400 356.66300 30.00100  1.000 37.50358  ? 413 ILE F CA  1 
ATOM   2685 C C   . ILE A 1 378 ? 167.03200 357.86700 29.08600  1.000 35.59102  ? 413 ILE F C   1 
ATOM   2686 O O   . ILE A 1 378 ? 167.02400 357.70600 27.86500  1.000 38.62420  ? 413 ILE F O   1 
ATOM   2687 C CB  . ILE A 1 378 ? 168.52100 356.14300 30.09900  1.000 37.50032  ? 413 ILE F CB  1 
ATOM   2688 C CG1 . ILE A 1 378 ? 168.61500 354.79800 30.83100  1.000 40.27111  ? 413 ILE F CG1 1 
ATOM   2689 C CG2 . ILE A 1 378 ? 169.42700 357.27400 30.64500  1.000 35.20783  ? 413 ILE F CG2 1 
ATOM   2690 C CD1 . ILE A 1 378 ? 170.04700 354.21800 30.85600  1.000 37.31997  ? 413 ILE F CD1 1 
ATOM   2691 N N   . VAL A 1 379 ? 167.00000 359.06600 29.65900  1.000 38.59177  ? 414 VAL F N   1 
ATOM   2692 C CA  . VAL A 1 379 ? 166.96000 360.31700 28.90400  1.000 34.79995  ? 414 VAL F CA  1 
ATOM   2693 C C   . VAL A 1 379 ? 168.07200 361.22400 29.40700  1.000 35.15171  ? 414 VAL F C   1 
ATOM   2694 O O   . VAL A 1 379 ? 168.10900 361.56500 30.59500  1.000 36.75070  ? 414 VAL F O   1 
ATOM   2695 C CB  . VAL A 1 379 ? 165.60600 361.04100 29.00700  1.000 39.13611  ? 414 VAL F CB  1 
ATOM   2696 C CG1 . VAL A 1 379 ? 165.71900 362.40100 28.32300  1.000 36.89693  ? 414 VAL F CG1 1 
ATOM   2697 C CG2 . VAL A 1 379 ? 164.50700 360.22900 28.31200  1.000 39.22428  ? 414 VAL F CG2 1 
ATOM   2698 N N   . SER A 1 380 ? 168.96200 361.62500 28.51200  1.000 36.58865  ? 415 SER F N   1 
ATOM   2699 C CA  . SER A 1 380 ? 169.99400 362.61500 28.77900  1.000 36.05941  ? 415 SER F CA  1 
ATOM   2700 C C   . SER A 1 380 ? 169.55200 363.87800 28.05200  1.000 37.13239  ? 415 SER F C   1 
ATOM   2701 O O   . SER A 1 380 ? 169.61000 363.93200 26.82100  1.000 37.38654  ? 415 SER F O   1 
ATOM   2702 C CB  . SER A 1 380 ? 171.38700 362.16300 28.30000  1.000 38.27840  ? 415 SER F CB  1 
ATOM   2703 O OG  . SER A 1 380 ? 171.84800 360.98900 28.97400  1.000 38.78576  ? 415 SER F OG  1 
ATOM   2704 N N   . CYS A 1 381 ? 169.07500 364.87100 28.80500  1.000 36.02049  ? 416 CYS F N   1 
ATOM   2705 C CA  . CYS A 1 381 ? 168.52500 366.10900 28.25000  1.000 35.91208  ? 416 CYS F CA  1 
ATOM   2706 C C   . CYS A 1 381 ? 169.47000 367.23900 28.56400  1.000 37.36872  ? 416 CYS F C   1 
ATOM   2707 O O   . CYS A 1 381 ? 169.72500 367.51600 29.73700  1.000 41.08728  ? 416 CYS F O   1 
ATOM   2708 C CB  . CYS A 1 381 ? 167.14600 366.44000 28.83500  1.000 40.72794  ? 416 CYS F CB  1 
ATOM   2709 S SG  . CYS A 1 381 ? 166.11700 367.49700 27.78500  1.000 43.93797  ? 416 CYS F SG  1 
ATOM   2710 N N   . TYR A 1 382 ? 169.89000 367.96700 27.53300  1.000 35.63617  ? 417 TYR F N   1 
ATOM   2711 C CA  . TYR A 1 382 ? 170.84100 369.05400 27.73400  1.000 40.53149  ? 417 TYR F CA  1 
ATOM   2712 C C   . TYR A 1 382 ? 170.52500 370.21900 26.81800  1.000 35.99194  ? 417 TYR F C   1 
ATOM   2713 O O   . TYR A 1 382 ? 169.74400 370.07400 25.88600  1.000 34.17378  ? 417 TYR F O   1 
ATOM   2714 C CB  . TYR A 1 382 ? 172.31400 368.60500 27.55000  1.000 38.44715  ? 417 TYR F CB  1 
ATOM   2715 C CG  . TYR A 1 382 ? 172.66600 367.43000 28.41000  1.000 40.18478  ? 417 TYR F CG  1 
ATOM   2716 C CD1 . TYR A 1 382 ? 172.82100 367.60800 29.78000  1.000 39.56200  ? 417 TYR F CD1 1 
ATOM   2717 C CD2 . TYR A 1 382 ? 172.95700 366.17200 27.86300  1.000 40.54799  ? 417 TYR F CD2 1 
ATOM   2718 C CE1 . TYR A 1 382 ? 173.16000 366.55000 30.61900  1.000 37.75609  ? 417 TYR F CE1 1 
ATOM   2719 C CE2 . TYR A 1 382 ? 173.30000 365.09900 28.67500  1.000 37.32001  ? 417 TYR F CE2 1 
ATOM   2720 C CZ  . TYR A 1 382 ? 173.39600 365.29400 30.05900  1.000 43.33051  ? 417 TYR F CZ  1 
ATOM   2721 O OH  . TYR A 1 382 ? 173.72800 364.25700 30.89400  1.000 36.41386  ? 417 TYR F OH  1 
ATOM   2722 N N   . GLY A 1 383 ? 170.91100 371.42200 27.25500  1.000 41.93156  ? 418 GLY F N   1 
ATOM   2723 C CA  . GLY A 1 383 ? 170.68900 372.58000 26.40700  1.000 35.81471  ? 418 GLY F CA  1 
ATOM   2724 C C   . GLY A 1 383 ? 169.20700 372.93700 26.44600  1.000 38.40017  ? 418 GLY F C   1 
ATOM   2725 O O   . GLY A 1 383 ? 168.56100 372.86100 27.48900  1.000 40.74594  ? 418 GLY F O   1 
ATOM   2726 N N   . LYS A 1 384 ? 168.67200 373.31400 25.29900  1.000 37.65360  ? 419 LYS F N   1 
ATOM   2727 C CA  . LYS A 1 384 ? 167.27300 373.68000 25.08500  1.000 42.82819  ? 419 LYS F CA  1 
ATOM   2728 C C   . LYS A 1 384 ? 166.40700 372.52900 24.60400  1.000 41.70119  ? 419 LYS F C   1 
ATOM   2729 O O   . LYS A 1 384 ? 165.26600 372.75800 24.19200  1.000 43.32610  ? 419 LYS F O   1 
ATOM   2730 C CB  . LYS A 1 384 ? 167.16900 374.85500 24.11000  1.000 40.71845  ? 419 LYS F CB  1 
ATOM   2731 C CG  . LYS A 1 384 ? 168.17300 375.93700 24.40100  1.000 42.90802  ? 419 LYS F CG  1 
ATOM   2732 C CD  . LYS A 1 384 ? 167.68600 377.18900 23.66600  1.000 45.16576  ? 419 LYS F CD  1 
ATOM   2733 C CE  . LYS A 1 384 ? 168.68300 378.33000 23.77700  1.000 46.19040  ? 419 LYS F CE  1 
ATOM   2734 N NZ  . LYS A 1 384 ? 168.34500 378.94800 25.11400  1.000 43.76531  ? 419 LYS F NZ  1 
ATOM   2735 N N   . THR A 1 385 ? 166.88800 371.30000 24.68400  1.000 39.37539  ? 420 THR F N   1 
ATOM   2736 C CA  . THR A 1 385 ? 166.13700 370.19400 24.11300  1.000 39.93307  ? 420 THR F CA  1 
ATOM   2737 C C   . THR A 1 385 ? 164.87500 369.94100 24.91400  1.000 36.63684  ? 420 THR F C   1 
ATOM   2738 O O   . THR A 1 385 ? 164.86800 369.96400 26.14900  1.000 33.90253  ? 420 THR F O   1 
ATOM   2739 C CB  . THR A 1 385 ? 166.97600 368.91200 24.06600  1.000 38.12985  ? 420 THR F CB  1 
ATOM   2740 O OG1 . THR A 1 385 ? 168.25100 369.20100 23.48200  1.000 36.65913  ? 420 THR F OG1 1 
ATOM   2741 C CG2 . THR A 1 385 ? 166.25100 367.84900 23.23800  1.000 34.44849  ? 420 THR F CG2 1 
ATOM   2742 N N   . LYS A 1 386 ? 163.82000 369.64400 24.18300  1.000 38.18960  ? 421 LYS F N   1 
ATOM   2743 C CA  . LYS A 1 386 ? 162.49500 369.37000 24.71200  1.000 36.84657  ? 421 LYS F CA  1 
ATOM   2744 C C   . LYS A 1 386 ? 162.37200 367.86000 24.92400  1.000 37.72335  ? 421 LYS F C   1 
ATOM   2745 O O   . LYS A 1 386 ? 162.44500 367.08500 23.97200  1.000 41.15347  ? 421 LYS F O   1 
ATOM   2746 C CB  . LYS A 1 386 ? 161.43500 369.88900 23.73900  1.000 36.32732  ? 421 LYS F CB  1 
ATOM   2747 C CG  . LYS A 1 386 ? 159.98400 369.57400 24.18300  1.000 41.35337  ? 421 LYS F CG  1 
ATOM   2748 C CD  . LYS A 1 386 ? 158.87700 370.06200 23.19200  1.000 48.06041  ? 421 LYS F CD  1 
ATOM   2749 C CE  . LYS A 1 386 ? 157.43800 369.69600 23.70900  1.000 51.53500  ? 421 LYS F CE  1 
ATOM   2750 N NZ  . LYS A 1 386 ? 157.05500 370.17800 25.14200  1.000 55.59763  ? 421 LYS F NZ  1 
ATOM   2751 N N   . CYS A 1 387 ? 162.55100 367.42700 26.15600  1.000 37.86889  ? 422 CYS F N   1 
ATOM   2752 C CA  . CYS A 1 387 ? 162.42000 366.02400 26.52700  1.000 35.18962  ? 422 CYS F CA  1 
ATOM   2753 C C   . CYS A 1 387 ? 161.15800 365.74800 27.32500  1.000 39.08922  ? 422 CYS F C   1 
ATOM   2754 O O   . CYS A 1 387 ? 161.01000 366.29400 28.42300  1.000 39.48197  ? 422 CYS F O   1 
ATOM   2755 C CB  . CYS A 1 387 ? 163.66000 365.59500 27.31300  1.000 36.12314  ? 422 CYS F CB  1 
ATOM   2756 S SG  . CYS A 1 387 ? 165.19000 366.16600 26.48500  1.000 39.00944  ? 422 CYS F SG  1 
ATOM   2757 N N   . THR A 1 388 ? 160.42800 364.70200 26.94700  1.000 37.91271  ? 423 THR F N   1 
ATOM   2758 C CA  . THR A 1 388 ? 159.14900 364.39400 27.58100  1.000 38.10973  ? 423 THR F CA  1 
ATOM   2759 C C   . THR A 1 388 ? 158.86200 362.90700 27.42500  1.000 42.79527  ? 423 THR F C   1 
ATOM   2760 O O   . THR A 1 388 ? 159.47900 362.20700 26.62000  1.000 39.01906  ? 423 THR F O   1 
ATOM   2761 C CB  . THR A 1 388 ? 157.95700 365.16300 27.00900  1.000 39.05076  ? 423 THR F CB  1 
ATOM   2762 O OG1 . THR A 1 388 ? 157.73300 364.72900 25.66600  1.000 41.63977  ? 423 THR F OG1 1 
ATOM   2763 C CG2 . THR A 1 388 ? 158.19100 366.70200 27.05500  1.000 38.00578  ? 423 THR F CG2 1 
ATOM   2764 N N   . ALA A 1 389 ? 157.90900 362.45100 28.23400  1.000 42.28272  ? 424 ALA F N   1 
ATOM   2765 C CA  . ALA A 1 389 ? 157.37800 361.09600 28.23300  1.000 43.17304  ? 424 ALA F CA  1 
ATOM   2766 C C   . ALA A 1 389 ? 155.86100 361.18300 28.24500  1.000 43.59806  ? 424 ALA F C   1 
ATOM   2767 O O   . ALA A 1 389 ? 155.29100 361.98700 29.00200  1.000 44.65277  ? 424 ALA F O   1 
ATOM   2768 C CB  . ALA A 1 389 ? 157.87800 360.28700 29.43700  1.000 41.13032  ? 424 ALA F CB  1 
ATOM   2769 N N   . SER A 1 390 ? 155.24400 360.53200 27.26300  1.000 43.51316  ? 425 SER F N   1 
ATOM   2770 C CA  . SER A 1 390 ? 153.81700 360.59200 27.02700  1.000 48.86448  ? 425 SER F CA  1 
ATOM   2771 C C   . SER A 1 390 ? 153.11300 359.24200 27.04200  1.000 52.41259  ? 425 SER F C   1 
ATOM   2772 O O   . SER A 1 390 ? 153.69700 358.17100 26.80200  1.000 52.19561  ? 425 SER F O   1 
ATOM   2773 C CB  . SER A 1 390 ? 153.48200 361.29700 25.71300  1.000 46.84429  ? 425 SER F CB  1 
ATOM   2774 O OG  . SER A 1 390 ? 154.05100 362.57800 25.69900  1.000 46.56002  ? 425 SER F OG  1 
ATOM   2775 N N   . ASN A 1 391 ? 151.82300 359.35400 27.33500  1.000 51.09454  ? 426 ASN F N   1 
ATOM   2776 C CA  . ASN A 1 391 ? 150.84300 358.29400 27.21300  1.000 55.36988  ? 426 ASN F CA  1 
ATOM   2777 C C   . ASN A 1 391 ? 149.97000 358.60300 26.00400  1.000 59.45466  ? 426 ASN F C   1 
ATOM   2778 O O   . ASN A 1 391 ? 149.66400 359.77200 25.73900  1.000 60.51974  ? 426 ASN F O   1 
ATOM   2779 C CB  . ASN A 1 391 ? 149.96800 358.22500 28.45000  1.000 59.12855  ? 426 ASN F CB  1 
ATOM   2780 C CG  . ASN A 1 391 ? 148.96800 357.09800 28.38100  1.000 61.95398  ? 426 ASN F CG  1 
ATOM   2781 O OD1 . ASN A 1 391 ? 147.88100 357.28700 27.84200  1.000 59.27707  ? 426 ASN F OD1 1 
ATOM   2782 N ND2 . ASN A 1 391 ? 149.29600 355.95000 28.96700  1.000 63.48401  ? 426 ASN F ND2 1 
ATOM   2783 N N   . LYS A 1 392 ? 149.55100 357.55600 25.28600  1.000 57.51202  ? 427 LYS F N   1 
ATOM   2784 C CA  . LYS A 1 392 ? 148.85500 357.75500 24.01700  1.000 60.22741  ? 427 LYS F CA  1 
ATOM   2785 C C   . LYS A 1 392 ? 147.55000 358.54100 24.19000  1.000 62.79788  ? 427 LYS F C   1 
ATOM   2786 O O   . LYS A 1 392 ? 147.18500 359.34500 23.32400  1.000 62.54464  ? 427 LYS F O   1 
ATOM   2787 C CB  . LYS A 1 392 ? 148.61400 356.40300 23.33900  1.000 68.68601  ? 427 LYS F CB  1 
ATOM   2788 C CG  . LYS A 1 392 ? 148.19900 356.50700 21.87900  1.000 66.47876  ? 427 LYS F CG  1 
ATOM   2789 C CD  . LYS A 1 392 ? 147.71400 355.18400 21.29800  1.000 73.05585  ? 427 LYS F CD  1 
ATOM   2790 C CE  . LYS A 1 392 ? 146.36800 354.74800 21.83000  1.000 79.74373  ? 427 LYS F CE  1 
ATOM   2791 N NZ  . LYS A 1 392 ? 145.89000 353.51800 21.10800  1.000 85.73348  ? 427 LYS F NZ  1 
ATOM   2792 N N   . ASN A 1 393 ? 146.84300 358.35200 25.29900  1.000 60.43362  ? 428 ASN F N   1 
ATOM   2793 C CA  . ASN A 1 393 ? 145.56500 359.03100 25.46900  1.000 64.77859  ? 428 ASN F CA  1 
ATOM   2794 C C   . ASN A 1 393 ? 145.59100 360.19400 26.44500  1.000 62.91979  ? 428 ASN F C   1 
ATOM   2795 O O   . ASN A 1 393 ? 144.76400 361.09500 26.31500  1.000 67.55983  ? 428 ASN F O   1 
ATOM   2796 C CB  . ASN A 1 393 ? 144.47000 358.04600 25.91900  1.000 64.97529  ? 428 ASN F CB  1 
ATOM   2797 C CG  . ASN A 1 393 ? 144.36500 356.81900 25.01700  1.000 72.37268  ? 428 ASN F CG  1 
ATOM   2798 O OD1 . ASN A 1 393 ? 144.50500 355.68100 25.46600  1.000 74.35294  ? 428 ASN F OD1 1 
ATOM   2799 N ND2 . ASN A 1 393 ? 144.08000 357.05500 23.73600  1.000 75.20523  ? 428 ASN F ND2 1 
ATOM   2800 N N   . ARG A 1 394 ? 146.55200 360.25000 27.34500  1.000 57.10983  ? 429 ARG F N   1 
ATOM   2801 C CA  . ARG A 1 394 ? 146.65800 361.35000 28.28900  1.000 55.84596  ? 429 ARG F CA  1 
ATOM   2802 C C   . ARG A 1 394 ? 147.58400 362.45900 27.84000  1.000 57.48998  ? 429 ARG F C   1 
ATOM   2803 O O   . ARG A 1 394 ? 147.48100 363.57700 28.36200  1.000 57.61762  ? 429 ARG F O   1 
ATOM   2804 C CB  . ARG A 1 394 ? 147.05100 360.80600 29.65300  1.000 57.29837  ? 429 ARG F CB  1 
ATOM   2805 C CG  . ARG A 1 394 ? 146.25900 359.55800 29.90500  1.000 61.14187  ? 429 ARG F CG  1 
ATOM   2806 C CD  . ARG A 1 394 ? 146.07500 359.28200 31.35900  1.000 65.97895  ? 429 ARG F CD  1 
ATOM   2807 N NE  . ARG A 1 394 ? 146.85600 358.11200 31.72600  1.000 70.37863  ? 429 ARG F NE  1 
ATOM   2808 C CZ  . ARG A 1 394 ? 146.44100 356.87500 31.48900  1.000 67.60814  ? 429 ARG F CZ  1 
ATOM   2809 N NH1 . ARG A 1 394 ? 145.25300 356.63900 30.95000  1.000 70.63830  ? 429 ARG F NH1 1 
ATOM   2810 N NH2 . ARG A 1 394 ? 147.23200 355.85400 31.79800  1.000 69.76711  ? 429 ARG F NH2 1 
ATOM   2811 N N   . GLY A 1 395 ? 148.51400 362.17600 26.94800  1.000 52.80574  ? 430 GLY F N   1 
ATOM   2812 C CA  . GLY A 1 395 ? 149.44100 363.20500 26.54700  1.000 53.56902  ? 430 GLY F CA  1 
ATOM   2813 C C   . GLY A 1 395 ? 150.70600 363.17600 27.36500  1.000 49.09955  ? 430 GLY F C   1 
ATOM   2814 O O   . GLY A 1 395 ? 151.06400 362.14200 27.93800  1.000 48.30570  ? 430 GLY F O   1 
ATOM   2815 N N   . ILE A 1 396 ? 151.34300 364.33400 27.49000  1.000 48.43823  ? 431 ILE F N   1 
ATOM   2816 C CA  . ILE A 1 396 ? 152.59500 364.42200 28.22500  1.000 47.16888  ? 431 ILE F CA  1 
ATOM   2817 C C   . ILE A 1 396 ? 152.34800 364.19600 29.70700  1.000 45.08269  ? 431 ILE F C   1 
ATOM   2818 O O   . ILE A 1 396 ? 151.53500 364.87900 30.33100  1.000 48.94552  ? 431 ILE F O   1 
ATOM   2819 C CB  . ILE A 1 396 ? 153.28100 365.76900 28.00100  1.000 41.71358  ? 431 ILE F CB  1 
ATOM   2820 C CG1 . ILE A 1 396 ? 153.78500 365.88500 26.56100  1.000 39.36622  ? 431 ILE F CG1 1 
ATOM   2821 C CG2 . ILE A 1 396 ? 154.41500 365.94500 29.03800  1.000 36.66647  ? 431 ILE F CG2 1 
ATOM   2822 C CD1 . ILE A 1 396 ? 154.38700 367.31100 26.26500  1.000 38.45686  ? 431 ILE F CD1 1 
ATOM   2823 N N   . ILE A 1 397 ? 152.96900 363.16300 30.25100  1.000 45.03443  ? 432 ILE F N   1 
ATOM   2824 C CA  . ILE A 1 397 ? 152.87300 362.84800 31.66800  1.000 43.60237  ? 432 ILE F CA  1 
ATOM   2825 C C   . ILE A 1 397 ? 154.16500 363.15200 32.41300  1.000 44.97678  ? 432 ILE F C   1 
ATOM   2826 O O   . ILE A 1 397 ? 154.16400 363.16100 33.65600  1.000 43.68007  ? 432 ILE F O   1 
ATOM   2827 C CB  . ILE A 1 397 ? 152.42000 361.39400 31.90400  1.000 55.82652  ? 432 ILE F CB  1 
ATOM   2828 C CG1 . ILE A 1 397 ? 153.35300 360.39200 31.22700  1.000 50.14142  ? 432 ILE F CG1 1 
ATOM   2829 C CG2 . ILE A 1 397 ? 150.98500 361.20700 31.37200  1.000 49.02214  ? 432 ILE F CG2 1 
ATOM   2830 C CD1 . ILE A 1 397 ? 153.13900 358.97200 31.78700  1.000 57.31957  ? 432 ILE F CD1 1 
ATOM   2831 N N   . LYS A 1 398 ? 155.26500 363.41000 31.70900  1.000 43.23951  ? 433 LYS F N   1 
ATOM   2832 C CA  . LYS A 1 398 ? 156.50400 363.76100 32.39400  1.000 40.69208  ? 433 LYS F CA  1 
ATOM   2833 C C   . LYS A 1 398 ? 157.40900 364.61200 31.52600  1.000 36.17059  ? 433 LYS F C   1 
ATOM   2834 O O   . LYS A 1 398 ? 157.55900 364.34400 30.34500  1.000 40.28550  ? 433 LYS F O   1 
ATOM   2835 C CB  . LYS A 1 398 ? 157.28900 362.48800 32.77700  1.000 44.84359  ? 433 LYS F CB  1 
ATOM   2836 C CG  . LYS A 1 398 ? 158.65300 362.75400 33.48500  1.000 39.83732  ? 433 LYS F CG  1 
ATOM   2837 C CD  . LYS A 1 398 ? 159.29800 361.50600 34.10100  1.000 47.10741  ? 433 LYS F CD  1 
ATOM   2838 C CE  . LYS A 1 398 ? 160.57200 361.84600 34.91900  1.000 44.57347  ? 433 LYS F CE  1 
ATOM   2839 N NZ  . LYS A 1 398 ? 160.36600 362.30900 36.31500  1.000 57.38274  ? 433 LYS F NZ  1 
ATOM   2840 N N   . THR A 1 399 ? 157.91700 365.69000 32.08300  1.000 35.56745  ? 434 THR F N   1 
ATOM   2841 C CA  . THR A 1 399 ? 158.90100 366.52800 31.42200  1.000 35.10110  ? 434 THR F CA  1 
ATOM   2842 C C   . THR A 1 399 ? 160.23000 366.39800 32.14700  1.000 43.45210  ? 434 THR F C   1 
ATOM   2843 O O   . THR A 1 399 ? 160.29200 366.62100 33.36100  1.000 40.44703  ? 434 THR F O   1 
ATOM   2844 C CB  . THR A 1 399 ? 158.45600 367.98500 31.36700  1.000 38.17201  ? 434 THR F CB  1 
ATOM   2845 O OG1 . THR A 1 399 ? 157.18100 368.04200 30.74400  1.000 39.24084  ? 434 THR F OG1 1 
ATOM   2846 C CG2 . THR A 1 399 ? 159.44300 368.81100 30.54000  1.000 37.79571  ? 434 THR F CG2 1 
ATOM   2847 N N   . PHE A 1 400 ? 161.26900 365.97900 31.41800  1.000 42.20556  ? 435 PHE F N   1 
ATOM   2848 C CA  . PHE A 1 400 ? 162.59900 365.77300 31.99300  1.000 44.43979  ? 435 PHE F CA  1 
ATOM   2849 C C   . PHE A 1 400 ? 163.32800 367.09800 32.13700  1.000 41.32579  ? 435 PHE F C   1 
ATOM   2850 O O   . PHE A 1 400 ? 163.28000 367.95200 31.23800  1.000 44.71303  ? 435 PHE F O   1 
ATOM   2851 C CB  . PHE A 1 400 ? 163.44600 364.82600 31.11900  1.000 40.39818  ? 435 PHE F CB  1 
ATOM   2852 C CG  . PHE A 1 400 ? 162.84500 363.44400 30.91300  1.000 36.60939  ? 435 PHE F CG  1 
ATOM   2853 C CD1 . PHE A 1 400 ? 163.05800 362.44700 31.84300  1.000 39.15755  ? 435 PHE F CD1 1 
ATOM   2854 C CD2 . PHE A 1 400 ? 162.04600 363.16200 29.81900  1.000 36.43067  ? 435 PHE F CD2 1 
ATOM   2855 C CE1 . PHE A 1 400 ? 162.50400 361.16100 31.65600  1.000 41.80978  ? 435 PHE F CE1 1 
ATOM   2856 C CE2 . PHE A 1 400 ? 161.49000 361.90200 29.61700  1.000 34.71953  ? 435 PHE F CE2 1 
ATOM   2857 C CZ  . PHE A 1 400 ? 161.72800 360.89500 30.53300  1.000 39.48794  ? 435 PHE F CZ  1 
ATOM   2858 N N   . SER A 1 401 ? 164.06300 367.25700 33.24100  1.000 44.47433  ? 436 SER F N   1 
ATOM   2859 C CA  . SER A 1 401 ? 164.87300 368.45800 33.29100  1.000 40.98142  ? 436 SER F CA  1 
ATOM   2860 C C   . SER A 1 401 ? 166.24900 368.14200 32.73700  1.000 41.75210  ? 436 SER F C   1 
ATOM   2861 O O   . SER A 1 401 ? 166.59200 366.98000 32.50900  1.000 44.10316  ? 436 SER F O   1 
ATOM   2862 C CB  . SER A 1 401 ? 164.99200 369.00000 34.72200  1.000 49.34986  ? 436 SER F CB  1 
ATOM   2863 O OG  . SER A 1 401 ? 163.71700 369.31700 35.28700  1.000 59.09057  ? 436 SER F OG  1 
ATOM   2864 N N   . ASN A 1 402 ? 167.10900 369.16200 32.72700  1.000 35.99913  ? 437 ASN F N   1 
ATOM   2865 C CA  . ASN A 1 402 ? 168.45500 369.02100 32.20700  1.000 44.85822  ? 437 ASN F CA  1 
ATOM   2866 C C   . ASN A 1 402 ? 169.20900 368.09300 33.13700  1.000 39.71151  ? 437 ASN F C   1 
ATOM   2867 O O   . ASN A 1 402 ? 169.05100 368.18000 34.34600  1.000 40.48118  ? 437 ASN F O   1 
ATOM   2868 C CB  . ASN A 1 402 ? 169.13500 370.39100 32.04400  1.000 38.65920  ? 437 ASN F CB  1 
ATOM   2869 C CG  . ASN A 1 402 ? 168.80700 370.99600 30.69200  1.000 49.86887  ? 437 ASN F CG  1 
ATOM   2870 O OD1 . ASN A 1 402 ? 167.97600 370.45700 29.97300  1.000 49.68527  ? 437 ASN F OD1 1 
ATOM   2871 N ND2 . ASN A 1 402 ? 169.45900 372.08300 30.32200  1.000 53.21799  ? 437 ASN F ND2 1 
ATOM   2872 N N   . GLY A 1 403 ? 169.86500 367.09300 32.56700  1.000 40.29492  ? 438 GLY F N   1 
ATOM   2873 C CA  . GLY A 1 403 ? 170.58700 366.06100 33.28700  1.000 38.23285  ? 438 GLY F CA  1 
ATOM   2874 C C   . GLY A 1 403 ? 170.19400 364.71100 32.75900  1.000 38.79741  ? 438 GLY F C   1 
ATOM   2875 O O   . GLY A 1 403 ? 169.61200 364.58100 31.67800  1.000 39.23239  ? 438 GLY F O   1 
ATOM   2876 N N   . CYS A 1 404 ? 170.51200 363.66700 33.50600  1.000 41.76399  ? 439 CYS F N   1 
ATOM   2877 C CA  . CYS A 1 404 ? 170.14600 362.32300 33.11000  1.000 37.76233  ? 439 CYS F CA  1 
ATOM   2878 C C   . CYS A 1 404 ? 169.06600 361.76700 33.99800  1.000 42.20057  ? 439 CYS F C   1 
ATOM   2879 O O   . CYS A 1 404 ? 169.17400 361.80200 35.20600  1.000 37.71300  ? 439 CYS F O   1 
ATOM   2880 C CB  . CYS A 1 404 ? 171.35400 361.39400 33.12100  1.000 39.80202  ? 439 CYS F CB  1 
ATOM   2881 S SG  . CYS A 1 404 ? 171.02500 359.68500 32.68100  1.000 42.31224  ? 439 CYS F SG  1 
ATOM   2882 N N   . ASP A 1 405 ? 168.03200 361.23200 33.38200  1.000 39.55825  ? 440 ASP F N   1 
ATOM   2883 C CA  . ASP A 1 405 ? 166.92200 360.72400 34.13800  1.000 42.15686  ? 440 ASP F CA  1 
ATOM   2884 C C   . ASP A 1 405 ? 166.36600 359.46700 33.51800  1.000 41.89549  ? 440 ASP F C   1 
ATOM   2885 O O   . ASP A 1 405 ? 166.84800 359.01900 32.49800  1.000 42.06893  ? 440 ASP F O   1 
ATOM   2886 C CB  . ASP A 1 405 ? 165.85800 361.81600 34.23900  1.000 41.64202  ? 440 ASP F CB  1 
ATOM   2887 C CG  . ASP A 1 405 ? 164.93100 361.64700 35.42300  1.000 47.10981  ? 440 ASP F CG  1 
ATOM   2888 O OD1 . ASP A 1 405 ? 164.97100 360.60400 36.08700  1.000 51.78256  ? 440 ASP F OD1 1 
ATOM   2889 O OD2 . ASP A 1 405 ? 164.14000 362.56900 35.68300  1.000 48.19211  ? 440 ASP F OD2 1 
ATOM   2890 N N   . TYR A 1 406 ? 165.34700 358.90200 34.13600  1.000 42.64777  ? 441 TYR F N   1 
ATOM   2891 C CA  . TYR A 1 406 ? 164.77800 357.66400 33.67700  1.000 41.88347  ? 441 TYR F CA  1 
ATOM   2892 C C   . TYR A 1 406 ? 163.31400 357.60300 33.94400  1.000 41.32108  ? 441 TYR F C   1 
ATOM   2893 O O   . TYR A 1 406 ? 162.82600 358.20100 34.88000  1.000 44.37790  ? 441 TYR F O   1 
ATOM   2894 C CB  . TYR A 1 406 ? 165.44000 356.52400 34.43100  1.000 42.34872  ? 441 TYR F CB  1 
ATOM   2895 C CG  . TYR A 1 406 ? 164.85100 355.15500 34.25900  1.000 42.81753  ? 441 TYR F CG  1 
ATOM   2896 C CD1 . TYR A 1 406 ? 165.23300 354.34200 33.20700  1.000 39.78498  ? 441 TYR F CD1 1 
ATOM   2897 C CD2 . TYR A 1 406 ? 163.95000 354.65200 35.17900  1.000 39.91624  ? 441 TYR F CD2 1 
ATOM   2898 C CE1 . TYR A 1 406 ? 164.70700 353.07700 33.05900  1.000 42.80397  ? 441 TYR F CE1 1 
ATOM   2899 C CE2 . TYR A 1 406 ? 163.41900 353.39100 35.03900  1.000 42.03152  ? 441 TYR F CE2 1 
ATOM   2900 C CZ  . TYR A 1 406 ? 163.80300 352.60700 33.98100  1.000 43.04978  ? 441 TYR F CZ  1 
ATOM   2901 O OH  . TYR A 1 406 ? 163.27600 351.35100 33.84900  1.000 45.44884  ? 441 TYR F OH  1 
ATOM   2902 N N   . VAL A 1 407 ? 162.60900 356.87300 33.12000  1.000 39.83025  ? 442 VAL F N   1 
ATOM   2903 C CA  . VAL A 1 407 ? 161.18600 356.66800 33.35800  1.000 42.92704  ? 442 VAL F CA  1 
ATOM   2904 C C   . VAL A 1 407 ? 160.89900 355.20700 33.03900  1.000 46.17519  ? 442 VAL F C   1 
ATOM   2905 O O   . VAL A 1 407 ? 161.46500 354.66100 32.08300  1.000 44.42895  ? 442 VAL F O   1 
ATOM   2906 C CB  . VAL A 1 407 ? 160.29600 357.61000 32.51900  1.000 39.66952  ? 442 VAL F CB  1 
ATOM   2907 C CG1 . VAL A 1 407 ? 160.43400 357.30500 31.04500  1.000 41.56843  ? 442 VAL F CG1 1 
ATOM   2908 C CG2 . VAL A 1 407 ? 158.88400 357.53300 32.98900  1.000 48.67024  ? 442 VAL F CG2 1 
ATOM   2909 N N   . SER A 1 408 ? 160.03900 354.56500 33.84200  1.000 45.28468  ? 443 SER F N   1 
ATOM   2910 C CA  . SER A 1 408 ? 159.62200 353.17300 33.65200  1.000 46.67951  ? 443 SER F CA  1 
ATOM   2911 C C   . SER A 1 408 ? 158.55300 353.10900 32.57600  1.000 44.79358  ? 443 SER F C   1 
ATOM   2912 O O   . SER A 1 408 ? 157.94500 354.12200 32.21700  1.000 47.27065  ? 443 SER F O   1 
ATOM   2913 C CB  . SER A 1 408 ? 159.10800 352.48900 34.92400  1.000 54.08616  ? 443 SER F CB  1 
ATOM   2914 O OG  . SER A 1 408 ? 157.92900 353.05100 35.43300  1.000 58.43826  ? 443 SER F OG  1 
ATOM   2915 N N   . ASN A 1 409 ? 158.30200 351.90400 32.07100  1.000 48.07729  ? 444 ASN F N   1 
ATOM   2916 C CA  . ASN A 1 409 ? 157.25700 351.75100 31.05700  1.000 54.06023  ? 444 ASN F CA  1 
ATOM   2917 C C   . ASN A 1 409 ? 155.83800 351.69200 31.63400  1.000 52.23440  ? 444 ASN F C   1 
ATOM   2918 O O   . ASN A 1 409 ? 154.89500 351.54700 30.84800  1.000 57.89689  ? 444 ASN F O   1 
ATOM   2919 C CB  . ASN A 1 409 ? 157.46400 350.49800 30.19600  1.000 45.28822  ? 444 ASN F CB  1 
ATOM   2920 C CG  . ASN A 1 409 ? 157.47100 349.23900 31.00300  1.000 51.41571  ? 444 ASN F CG  1 
ATOM   2921 O OD1 . ASN A 1 409 ? 157.35800 349.27700 32.22900  1.000 52.70737  ? 444 ASN F OD1 1 
ATOM   2922 N ND2 . ASN A 1 409 ? 157.63800 348.10700 30.32700  1.000 48.09077  ? 444 ASN F ND2 1 
ATOM   2923 N N   . LYS A 1 410 ? 155.65000 351.67100 32.95600  1.000 49.59180  ? 445 LYS F N   1 
ATOM   2924 C CA  . LYS A 1 410 ? 154.28500 351.63700 33.51200  1.000 56.62891  ? 445 LYS F CA  1 
ATOM   2925 C C   . LYS A 1 410 ? 153.57400 352.97000 33.34700  1.000 50.41799  ? 445 LYS F C   1 
ATOM   2926 O O   . LYS A 1 410 ? 153.87400 353.95200 34.02400  1.000 54.86847  ? 445 LYS F O   1 
ATOM   2927 C CB  . LYS A 1 410 ? 154.18600 351.18900 34.97400  1.000 62.64571  ? 445 LYS F CB  1 
ATOM   2928 C CG  . LYS A 1 410 ? 154.49000 349.73000 35.37200  1.000 65.79895  ? 445 LYS F CG  1 
ATOM   2929 C CD  . LYS A 1 410 ? 155.67700 349.33500 36.18400  1.000 69.41551  ? 445 LYS F CD  1 
ATOM   2930 C CE  . LYS A 1 410 ? 155.51600 347.80700 36.46100  1.000 67.45448  ? 445 LYS F CE  1 
ATOM   2931 N NZ  . LYS A 1 410 ? 155.33300 346.92700 35.25400  1.000 70.15475  ? 445 LYS F NZ  1 
ATOM   2932 N N   . GLY A 1 411 ? 152.67900 353.01400 32.36200  1.000 54.06064  ? 446 GLY F N   1 
ATOM   2933 C CA  . GLY A 1 411 ? 151.90600 354.19300 32.04500  1.000 57.69460  ? 446 GLY F CA  1 
ATOM   2934 C C   . GLY A 1 411 ? 152.49800 355.03800 30.94000  1.000 58.94013  ? 446 GLY F C   1 
ATOM   2935 O O   . GLY A 1 411 ? 151.84700 355.98700 30.48400  1.000 60.41791  ? 446 GLY F O   1 
ATOM   2936 N N   . VAL A 1 412 ? 153.70700 354.70800 30.49400  1.000 49.81643  ? 447 VAL F N   1 
ATOM   2937 C CA  . VAL A 1 412 ? 154.40300 355.44600 29.46200  1.000 47.64684  ? 447 VAL F CA  1 
ATOM   2938 C C   . VAL A 1 412 ? 154.38400 354.63000 28.18500  1.000 49.78688  ? 447 VAL F C   1 
ATOM   2939 O O   . VAL A 1 412 ? 154.69400 353.43600 28.19000  1.000 51.49998  ? 447 VAL F O   1 
ATOM   2940 C CB  . VAL A 1 412 ? 155.84300 355.77300 29.88100  1.000 48.21429  ? 447 VAL F CB  1 
ATOM   2941 C CG1 . VAL A 1 412 ? 156.58900 356.47700 28.72900  1.000 38.50838  ? 447 VAL F CG1 1 
ATOM   2942 C CG2 . VAL A 1 412 ? 155.81600 356.61500 31.13900  1.000 43.81029  ? 447 VAL F CG2 1 
ATOM   2943 N N   . ASP A 1 413 ? 154.07300 355.28500 27.09100  1.000 47.87438  ? 448 ASP F N   1 
ATOM   2944 C CA  . ASP A 1 413 ? 154.07800 354.64800 25.79900  1.000 47.92171  ? 448 ASP F CA  1 
ATOM   2945 C C   . ASP A 1 413 ? 155.26100 355.14200 24.98900  1.000 48.85407  ? 448 ASP F C   1 
ATOM   2946 O O   . ASP A 1 413 ? 155.93700 354.35200 24.31600  1.000 44.70681  ? 448 ASP F O   1 
ATOM   2947 C CB  . ASP A 1 413 ? 152.76300 354.93500 25.05500  1.000 49.01454  ? 448 ASP F CB  1 
ATOM   2948 C CG  . ASP A 1 413 ? 151.55700 354.31800 25.74600  1.000 56.05782  ? 448 ASP F CG  1 
ATOM   2949 O OD1 . ASP A 1 413 ? 151.72100 353.24300 26.36400  1.000 57.36059  ? 448 ASP F OD1 1 
ATOM   2950 O OD2 . ASP A 1 413 ? 150.45100 354.91400 25.68300  1.000 60.33683  ? 448 ASP F OD2 1 
ATOM   2951 N N   . THR A 1 414 ? 155.48200 356.45500 24.99900  1.000 43.51366  ? 449 THR F N   1 
ATOM   2952 C CA  . THR A 1 414 ? 156.54400 357.04500 24.21600  1.000 46.23600  ? 449 THR F CA  1 
ATOM   2953 C C   . THR A 1 414 ? 157.38100 358.03000 25.01600  1.000 50.13404  ? 449 THR F C   1 
ATOM   2954 O O   . THR A 1 414 ? 157.00300 358.51000 26.09600  1.000 45.33784  ? 449 THR F O   1 
ATOM   2955 C CB  . THR A 1 414 ? 156.02500 357.77800 23.01800  1.000 46.64239  ? 449 THR F CB  1 
ATOM   2956 O OG1 . THR A 1 414 ? 155.18800 358.81300 23.49300  1.000 45.05434  ? 449 THR F OG1 1 
ATOM   2957 C CG2 . THR A 1 414 ? 155.20700 356.80800 22.13700  1.000 45.90770  ? 449 THR F CG2 1 
ATOM   2958 N N   . VAL A 1 415 ? 158.55600 358.27400 24.45600  1.000 45.70704  ? 450 VAL F N   1 
ATOM   2959 C CA  . VAL A 1 415 ? 159.50900 359.25100 24.94300  1.000 43.19831  ? 450 VAL F CA  1 
ATOM   2960 C C   . VAL A 1 415 ? 159.97500 360.08700 23.76200  1.000 44.64862  ? 450 VAL F C   1 
ATOM   2961 O O   . VAL A 1 415 ? 160.32300 359.53600 22.71600  1.000 44.73003  ? 450 VAL F O   1 
ATOM   2962 C CB  . VAL A 1 415 ? 160.70100 358.54800 25.61000  1.000 45.63891  ? 450 VAL F CB  1 
ATOM   2963 C CG1 . VAL A 1 415 ? 161.83600 359.51200 25.78800  1.000 44.35242  ? 450 VAL F CG1 1 
ATOM   2964 C CG2 . VAL A 1 415 ? 160.25400 357.96500 26.94400  1.000 39.30251  ? 450 VAL F CG2 1 
ATOM   2965 N N   . SER A 1 416 ? 159.86500 361.40300 23.86600  1.000 39.17029  ? 451 SER F N   1 
ATOM   2966 C CA  . SER A 1 416 ? 160.28500 362.29800 22.79500  1.000 41.62890  ? 451 SER F CA  1 
ATOM   2967 C C   . SER A 1 416 ? 161.48500 363.10400 23.25700  1.000 43.53702  ? 451 SER F C   1 
ATOM   2968 O O   . SER A 1 416 ? 161.46700 363.68300 24.35300  1.000 43.97014  ? 451 SER F O   1 
ATOM   2969 C CB  . SER A 1 416 ? 159.16500 363.20700 22.31000  1.000 37.01493  ? 451 SER F CB  1 
ATOM   2970 O OG  . SER A 1 416 ? 158.19000 362.36800 21.72200  1.000 50.83969  ? 451 SER F OG  1 
ATOM   2971 N N   . VAL A 1 417 ? 162.52900 363.11700 22.43700  1.000 40.32348  ? 452 VAL F N   1 
ATOM   2972 C CA  . VAL A 1 417 ? 163.73500 363.90000 22.67900  1.000 38.05806  ? 452 VAL F CA  1 
ATOM   2973 C C   . VAL A 1 417 ? 164.03600 364.72500 21.42700  1.000 39.29175  ? 452 VAL F C   1 
ATOM   2974 O O   . VAL A 1 417 ? 164.30600 364.15800 20.35100  1.000 41.58872  ? 452 VAL F O   1 
ATOM   2975 C CB  . VAL A 1 417 ? 164.92100 363.01000 23.05100  1.000 43.95731  ? 452 VAL F CB  1 
ATOM   2976 C CG1 . VAL A 1 417 ? 166.17600 363.84700 23.11200  1.000 37.51390  ? 452 VAL F CG1 1 
ATOM   2977 C CG2 . VAL A 1 417 ? 164.62800 362.25100 24.38500  1.000 41.61503  ? 452 VAL F CG2 1 
ATOM   2978 N N   . GLY A 1 418 ? 163.85700 366.04200 21.52100  1.000 41.03650  ? 453 GLY F N   1 
ATOM   2979 C CA  . GLY A 1 418 ? 164.03100 366.88400 20.33300  1.000 40.24375  ? 453 GLY F CA  1 
ATOM   2980 C C   . GLY A 1 418 ? 162.94000 366.54800 19.32400  1.000 44.81270  ? 453 GLY F C   1 
ATOM   2981 O O   . GLY A 1 418 ? 161.77100 366.37800 19.69300  1.000 46.30959  ? 453 GLY F O   1 
ATOM   2982 N N   . ASN A 1 419 ? 163.32900 366.27500 18.08300  1.000 38.92163  ? 454 ASN F N   1 
ATOM   2983 C CA  . ASN A 1 419 ? 162.37700 365.90200 17.05000  1.000 38.61923  ? 454 ASN F CA  1 
ATOM   2984 C C   . ASN A 1 419 ? 162.20800 364.41300 16.88500  1.000 44.06938  ? 454 ASN F C   1 
ATOM   2985 O O   . ASN A 1 419 ? 161.52600 363.99900 15.94700  1.000 47.89637  ? 454 ASN F O   1 
ATOM   2986 C CB  . ASN A 1 419 ? 162.88000 366.45000 15.70300  1.000 39.34408  ? 454 ASN F CB  1 
ATOM   2987 C CG  . ASN A 1 419 ? 162.98400 367.95800 15.68400  1.000 41.28637  ? 454 ASN F CG  1 
ATOM   2988 O OD1 . ASN A 1 419 ? 162.23300 368.60300 16.39400  1.000 41.06945  ? 454 ASN F OD1 1 
ATOM   2989 N ND2 . ASN A 1 419 ? 163.98800 368.52400 14.96400  1.000 37.28408  ? 454 ASN F ND2 1 
ATOM   2990 N N   . THR A 1 420 ? 162.66700 363.61100 17.84100  1.000 45.47490  ? 455 THR F N   1 
ATOM   2991 C CA  . THR A 1 420 ? 162.60200 362.15500 17.74000  1.000 45.22776  ? 455 THR F CA  1 
ATOM   2992 C C   . THR A 1 420 ? 161.68200 361.52900 18.77100  1.000 43.36113  ? 455 THR F C   1 
ATOM   2993 O O   . THR A 1 420 ? 161.80800 361.81000 19.96700  1.000 44.67005  ? 455 THR F O   1 
ATOM   2994 C CB  . THR A 1 420 ? 163.98100 361.50300 17.87100  1.000 44.93246  ? 455 THR F CB  1 
ATOM   2995 O OG1 . THR A 1 420 ? 164.85100 362.02800 16.86600  1.000 47.90801  ? 455 THR F OG1 1 
ATOM   2996 C CG2 . THR A 1 420 ? 163.84100 359.99800 17.64300  1.000 47.15514  ? 455 THR F CG2 1 
ATOM   2997 N N   . LEU A 1 421 ? 160.86400 360.58200 18.32300  1.000 39.35267  ? 456 LEU F N   1 
ATOM   2998 C CA  . LEU A 1 421 ? 159.92800 359.87000 19.17000  1.000 41.37961  ? 456 LEU F CA  1 
ATOM   2999 C C   . LEU A 1 421 ? 160.34000 358.40500 19.21800  1.000 47.96257  ? 456 LEU F C   1 
ATOM   3000 O O   . LEU A 1 421 ? 160.66700 357.82300 18.18100  1.000 48.21685  ? 456 LEU F O   1 
ATOM   3001 C CB  . LEU A 1 421 ? 158.50500 359.97900 18.62300  1.000 42.00241  ? 456 LEU F CB  1 
ATOM   3002 C CG  . LEU A 1 421 ? 157.51800 359.27800 19.55700  1.000 45.83203  ? 456 LEU F CG  1 
ATOM   3003 C CD1 . LEU A 1 421 ? 156.28500 360.07200 19.73200  1.000 44.17052  ? 456 LEU F CD1 1 
ATOM   3004 C CD2 . LEU A 1 421 ? 157.17600 357.92300 18.97300  1.000 51.59379  ? 456 LEU F CD2 1 
ATOM   3005 N N   . TYR A 1 422 ? 160.57300 357.91400 20.43900  1.000 43.81897  ? 457 TYR F N   1 
ATOM   3006 C CA  . TYR A 1 422 ? 160.90000 356.54000 20.79400  1.000 41.73893  ? 457 TYR F CA  1 
ATOM   3007 C C   . TYR A 1 422 ? 159.70300 355.84100 21.42000  1.000 47.71476  ? 457 TYR F C   1 
ATOM   3008 O O   . TYR A 1 422 ? 159.01100 356.42300 22.26400  1.000 44.06636  ? 457 TYR F O   1 
ATOM   3009 C CB  . TYR A 1 422 ? 162.06800 356.47800 21.78800  1.000 44.79627  ? 457 TYR F CB  1 
ATOM   3010 C CG  . TYR A 1 422 ? 163.28300 357.22700 21.33300  1.000 46.75800  ? 457 TYR F CG  1 
ATOM   3011 C CD1 . TYR A 1 422 ? 163.42600 358.59100 21.60700  1.000 48.07571  ? 457 TYR F CD1 1 
ATOM   3012 C CD2 . TYR A 1 422 ? 164.27800 356.58600 20.59400  1.000 49.33325  ? 457 TYR F CD2 1 
ATOM   3013 C CE1 . TYR A 1 422 ? 164.54000 359.30300 21.18200  1.000 48.01225  ? 457 TYR F CE1 1 
ATOM   3014 C CE2 . TYR A 1 422 ? 165.40800 357.29200 20.15600  1.000 55.50999  ? 457 TYR F CE2 1 
ATOM   3015 C CZ  . TYR A 1 422 ? 165.52200 358.64900 20.45000  1.000 55.03100  ? 457 TYR F CZ  1 
ATOM   3016 O OH  . TYR A 1 422 ? 166.61400 359.35800 20.03500  1.000 61.00186  ? 457 TYR F OH  1 
ATOM   3017 N N   . TYR A 1 423 ? 159.54000 354.56000 21.11000  1.000 42.91092  ? 458 TYR F N   1 
ATOM   3018 C CA  . TYR A 1 423 ? 158.54300 353.73800 21.76800  1.000 42.42139  ? 458 TYR F CA  1 
ATOM   3019 C C   . TYR A 1 423 ? 159.18800 352.92100 22.88000  1.000 48.17213  ? 458 TYR F C   1 
ATOM   3020 O O   . TYR A 1 423 ? 160.22300 352.27900 22.69300  1.000 44.60759  ? 458 TYR F O   1 
ATOM   3021 C CB  . TYR A 1 423 ? 157.84700 352.80800 20.77100  1.000 51.79752  ? 458 TYR F CB  1 
ATOM   3022 C CG  . TYR A 1 423 ? 157.12100 353.54900 19.68600  1.000 49.96979  ? 458 TYR F CG  1 
ATOM   3023 C CD1 . TYR A 1 423 ? 157.79400 353.96300 18.54600  1.000 53.42473  ? 458 TYR F CD1 1 
ATOM   3024 C CD2 . TYR A 1 423 ? 155.77700 353.84800 19.80000  1.000 53.32179  ? 458 TYR F CD2 1 
ATOM   3025 C CE1 . TYR A 1 423 ? 157.14000 354.64700 17.53800  1.000 59.17177  ? 458 TYR F CE1 1 
ATOM   3026 C CE2 . TYR A 1 423 ? 155.11200 354.55400 18.80300  1.000 54.05427  ? 458 TYR F CE2 1 
ATOM   3027 C CZ  . TYR A 1 423 ? 155.79800 354.94600 17.67500  1.000 56.37827  ? 458 TYR F CZ  1 
ATOM   3028 O OH  . TYR A 1 423 ? 155.15200 355.63700 16.66500  1.000 65.20084  ? 458 TYR F OH  1 
ATOM   3029 N N   . VAL A 1 424 ? 158.57800 352.96000 24.01100  1.000 42.73978  ? 459 VAL F N   1 
ATOM   3030 C CA  . VAL A 1 424 ? 158.95400 352.16500 25.16000  1.000 43.99515  ? 459 VAL F CA  1 
ATOM   3031 C C   . VAL A 1 424 ? 158.50600 350.71900 24.99900  1.000 50.94308  ? 459 VAL F C   1 
ATOM   3032 O O   . VAL A 1 424 ? 157.46700 350.43000 24.38500  1.000 52.26821  ? 459 VAL F O   1 
ATOM   3033 C CB  . VAL A 1 424 ? 158.40700 352.79800 26.44400  1.000 50.10844  ? 459 VAL F CB  1 
ATOM   3034 C CG1 . VAL A 1 424 ? 158.87500 352.01200 27.60700  1.000 51.64006  ? 459 VAL F CG1 1 
ATOM   3035 C CG2 . VAL A 1 424 ? 159.01400 354.20300 26.57300  1.000 47.19747  ? 459 VAL F CG2 1 
ATOM   3036 N N   . ASN A 1 425 ? 159.38400 349.80300 25.39000  1.000 49.66717  ? 460 ASN F N   1 
ATOM   3037 C CA  . ASN A 1 425 ? 159.05700 348.38400 25.35000  1.000 52.27715  ? 460 ASN F CA  1 
ATOM   3038 C C   . ASN A 1 425 ? 157.96000 348.10400 26.37200  1.000 55.78511  ? 460 ASN F C   1 
ATOM   3039 O O   . ASN A 1 425 ? 158.03900 348.56200 27.52200  1.000 57.12514  ? 460 ASN F O   1 
ATOM   3040 C CB  . ASN A 1 425 ? 160.31100 347.58400 25.69500  1.000 53.34798  ? 460 ASN F CB  1 
ATOM   3041 C CG  . ASN A 1 425 ? 160.10800 346.08600 25.62300  1.000 61.84985  ? 460 ASN F CG  1 
ATOM   3042 O OD1 . ASN A 1 425 ? 159.00900 345.57100 25.84900  1.000 61.23816  ? 460 ASN F OD1 1 
ATOM   3043 N ND2 . ASN A 1 425 ? 161.19200 345.36900 25.37400  1.000 61.26890  ? 460 ASN F ND2 1 
ATOM   3044 N N   . LYS A 1 426 ? 156.89000 347.41800 25.93700  1.000 57.62517  ? 461 LYS F N   1 
ATOM   3045 C CA  . LYS A 1 426 ? 155.75100 347.14800 26.81600  1.000 59.10399  ? 461 LYS F CA  1 
ATOM   3046 C C   . LYS A 1 426 ? 155.85800 345.82500 27.58100  1.000 61.52046  ? 461 LYS F C   1 
ATOM   3047 O O   . LYS A 1 426 ? 154.83200 345.25800 27.97300  1.000 69.01766  ? 461 LYS F O   1 
ATOM   3048 C CB  . LYS A 1 426 ? 154.43700 347.23000 26.04000  1.000 58.62981  ? 461 LYS F CB  1 
ATOM   3049 C CG  . LYS A 1 426 ? 154.22900 348.53700 25.30900  1.000 58.75015  ? 461 LYS F CG  1 
ATOM   3050 C CD  . LYS A 1 426 ? 154.33700 349.76400 26.26100  1.000 61.63623  ? 461 LYS F CD  1 
ATOM   3051 C CE  . LYS A 1 426 ? 153.23000 349.79200 27.33100  1.000 62.40933  ? 461 LYS F CE  1 
ATOM   3052 N NZ  . LYS A 1 426 ? 153.28400 350.94800 28.33600  1.000 55.89973  ? 461 LYS F NZ  1 
ATOM   3053 N N   . GLN A 1 427 ? 157.06900 345.36600 27.87200  1.000 63.14931  ? 462 GLN F N   1 
ATOM   3054 C CA  . GLN A 1 427 ? 157.28300 344.14100 28.63500  1.000 61.40034  ? 462 GLN F CA  1 
ATOM   3055 C C   . GLN A 1 427 ? 156.96100 344.37100 30.11000  1.000 65.46055  ? 462 GLN F C   1 
ATOM   3056 O O   . GLN A 1 427 ? 157.27900 345.42500 30.66700  1.000 59.31623  ? 462 GLN F O   1 
ATOM   3057 C CB  . GLN A 1 427 ? 158.75800 343.75100 28.53400  1.000 64.17677  ? 462 GLN F CB  1 
ATOM   3058 C CG  . GLN A 1 427 ? 159.19600 342.54000 29.29200  1.000 67.76290  ? 462 GLN F CG  1 
ATOM   3059 C CD  . GLN A 1 427 ? 160.05300 341.64300 28.44300  1.000 76.77582  ? 462 GLN F CD  1 
ATOM   3060 O OE1 . GLN A 1 427 ? 160.85400 342.13600 27.64900  1.000 77.84164  ? 462 GLN F OE1 1 
ATOM   3061 N NE2 . GLN A 1 427 ? 159.93200 340.32800 28.63100  1.000 73.73953  ? 462 GLN F NE2 1 
ATOM   3062 N N   . GLU A 1 428 ? 156.33300 343.39000 30.75400  1.000 62.34686  ? 463 GLU F N   1 
ATOM   3063 C CA  . GLU A 1 428 ? 156.01200 343.51600 32.17400  1.000 65.76404  ? 463 GLU F CA  1 
ATOM   3064 C C   . GLU A 1 428 ? 157.23800 343.22300 33.03700  1.000 60.03883  ? 463 GLU F C   1 
ATOM   3065 O O   . GLU A 1 428 ? 158.02500 342.33400 32.72000  1.000 60.96715  ? 463 GLU F O   1 
ATOM   3066 C CB  . GLU A 1 428 ? 154.85700 342.59700 32.57000  1.000 78.08117  ? 463 GLU F CB  1 
ATOM   3067 C CG  . GLU A 1 428 ? 153.50600 343.29600 32.45800  1.000 88.67495  ? 463 GLU F CG  1 
ATOM   3068 C CD  . GLU A 1 428 ? 152.40800 342.38500 31.95400  1.000 104.45281 ? 463 GLU F CD  1 
ATOM   3069 O OE1 . GLU A 1 428 ? 152.49800 341.92500 30.79000  1.000 107.85396 ? 463 GLU F OE1 1 
ATOM   3070 O OE2 . GLU A 1 428 ? 151.44300 342.14900 32.71100  1.000 111.08199 ? 463 GLU F OE2 1 
ATOM   3071 N N   . GLY A 1 429 ? 157.43800 344.02900 34.07600  1.000 58.59255  ? 464 GLY F N   1 
ATOM   3072 C CA  . GLY A 1 429 ? 158.56500 343.87000 34.98400  1.000 49.91103  ? 464 GLY F CA  1 
ATOM   3073 C C   . GLY A 1 429 ? 158.61000 345.03500 35.94800  1.000 56.17933  ? 464 GLY F C   1 
ATOM   3074 O O   . GLY A 1 429 ? 157.91700 346.03800 35.77600  1.000 59.42985  ? 464 GLY F O   1 
ATOM   3075 N N   . LYS A 1 430 ? 159.45400 344.90000 36.97100  1.000 51.68517  ? 465 LYS F N   1 
ATOM   3076 C CA  . LYS A 1 430 ? 159.64600 345.93500 37.98100  1.000 54.31279  ? 465 LYS F CA  1 
ATOM   3077 C C   . LYS A 1 430 ? 160.91300 346.74200 37.70200  1.000 54.73991  ? 465 LYS F C   1 
ATOM   3078 O O   . LYS A 1 430 ? 162.00100 346.16700 37.58300  1.000 52.27259  ? 465 LYS F O   1 
ATOM   3079 C CB  . LYS A 1 430 ? 159.78700 345.34500 39.39000  1.000 65.37080  ? 465 LYS F CB  1 
ATOM   3080 C CG  . LYS A 1 430 ? 158.60200 344.59800 40.01300  1.000 74.89380  ? 465 LYS F CG  1 
ATOM   3081 C CD  . LYS A 1 430 ? 159.08400 343.88000 41.29900  1.000 76.96129  ? 465 LYS F CD  1 
ATOM   3082 C CE  . LYS A 1 430 ? 158.15500 342.75200 41.75600  1.000 86.40112  ? 465 LYS F CE  1 
ATOM   3083 N NZ  . LYS A 1 430 ? 157.24200 343.17700 42.86400  1.000 88.44042  ? 465 LYS F NZ  1 
ATOM   3084 N N   . SER A 1 431 ? 160.78200 348.06800 37.69300  1.000 52.00540  ? 466 SER F N   1 
ATOM   3085 C CA  . SER A 1 431 ? 161.90900 348.99300 37.68900  1.000 51.67442  ? 466 SER F CA  1 
ATOM   3086 C C   . SER A 1 431 ? 162.15500 349.57400 39.07100  1.000 52.52115  ? 466 SER F C   1 
ATOM   3087 O O   . SER A 1 431 ? 161.22200 349.82200 39.83300  1.000 59.01538  ? 466 SER F O   1 
ATOM   3088 C CB  . SER A 1 431 ? 161.68100 350.17300 36.74200  1.000 47.37522  ? 466 SER F CB  1 
ATOM   3089 O OG  . SER A 1 431 ? 161.51300 349.75800 35.41500  1.000 53.87801  ? 466 SER F OG  1 
ATOM   3090 N N   . LEU A 1 432 ? 163.42100 349.84700 39.35900  1.000 51.20060  ? 467 LEU F N   1 
ATOM   3091 C CA  . LEU A 1 432 ? 163.85800 350.43300 40.62100  1.000 47.36448  ? 467 LEU F CA  1 
ATOM   3092 C C   . LEU A 1 432 ? 164.73700 351.61300 40.24800  1.000 51.68500  ? 467 LEU F C   1 
ATOM   3093 O O   . LEU A 1 432 ? 165.73200 351.45200 39.52800  1.000 47.88322  ? 467 LEU F O   1 
ATOM   3094 C CB  . LEU A 1 432 ? 164.65500 349.46500 41.50600  1.000 49.73245  ? 467 LEU F CB  1 
ATOM   3095 C CG  . LEU A 1 432 ? 165.21200 349.90900 42.88700  1.000 57.23250  ? 467 LEU F CG  1 
ATOM   3096 C CD1 . LEU A 1 432 ? 164.18200 350.43900 43.90700  1.000 56.53311  ? 467 LEU F CD1 1 
ATOM   3097 C CD2 . LEU A 1 432 ? 166.15500 348.87100 43.53500  1.000 49.70004  ? 467 LEU F CD2 1 
ATOM   3098 N N   . TYR A 1 433 ? 164.33500 352.79200 40.69300  1.000 49.47821  ? 468 TYR F N   1 
ATOM   3099 C CA  . TYR A 1 433 ? 165.06100 354.02500 40.45600  1.000 48.96780  ? 468 TYR F CA  1 
ATOM   3100 C C   . TYR A 1 433 ? 165.97400 354.19600 41.65300  1.000 51.05271  ? 468 TYR F C   1 
ATOM   3101 O O   . TYR A 1 433 ? 165.50000 354.48600 42.74600  1.000 55.02498  ? 468 TYR F O   1 
ATOM   3102 C CB  . TYR A 1 433 ? 164.09300 355.20100 40.35900  1.000 44.10913  ? 468 TYR F CB  1 
ATOM   3103 C CG  . TYR A 1 433 ? 164.65400 356.46900 39.73800  1.000 43.25685  ? 468 TYR F CG  1 
ATOM   3104 C CD1 . TYR A 1 433 ? 165.53900 357.25900 40.44900  1.000 41.51043  ? 468 TYR F CD1 1 
ATOM   3105 C CD2 . TYR A 1 433 ? 164.20400 356.93300 38.51000  1.000 44.38709  ? 468 TYR F CD2 1 
ATOM   3106 C CE1 . TYR A 1 433 ? 166.03400 358.45500 39.92500  1.000 44.98345  ? 468 TYR F CE1 1 
ATOM   3107 C CE2 . TYR A 1 433 ? 164.68100 358.13100 37.97700  1.000 43.34843  ? 468 TYR F CE2 1 
ATOM   3108 C CZ  . TYR A 1 433 ? 165.59500 358.88600 38.69300  1.000 41.28522  ? 468 TYR F CZ  1 
ATOM   3109 O OH  . TYR A 1 433 ? 166.07000 360.06700 38.16200  1.000 43.71126  ? 468 TYR F OH  1 
ATOM   3110 N N   . VAL A 1 434 ? 167.27600 354.00400 41.46300  1.000 50.81575  ? 469 VAL F N   1 
ATOM   3111 C CA  . VAL A 1 434 ? 168.24900 354.11600 42.53900  1.000 47.58832  ? 469 VAL F CA  1 
ATOM   3112 C C   . VAL A 1 434 ? 168.76200 355.55200 42.53100  1.000 55.04305  ? 469 VAL F C   1 
ATOM   3113 O O   . VAL A 1 434 ? 169.64500 355.91700 41.74600  1.000 54.22667  ? 469 VAL F O   1 
ATOM   3114 C CB  . VAL A 1 434 ? 169.38300 353.10500 42.36400  1.000 51.95275  ? 469 VAL F CB  1 
ATOM   3115 C CG1 . VAL A 1 434 ? 170.39100 353.23200 43.49800  1.000 49.53348  ? 469 VAL F CG1 1 
ATOM   3116 C CG2 . VAL A 1 434 ? 168.82900 351.68400 42.21900  1.000 47.47307  ? 469 VAL F CG2 1 
ATOM   3117 N N   . LYS A 1 435 ? 168.22100 356.37500 43.41300  1.000 51.08007  ? 470 LYS F N   1 
ATOM   3118 C CA  . LYS A 1 435 ? 168.61400 357.77700 43.45200  1.000 47.26732  ? 470 LYS F CA  1 
ATOM   3119 C C   . LYS A 1 435 ? 170.04600 357.91900 43.93100  1.000 52.81376  ? 470 LYS F C   1 
ATOM   3120 O O   . LYS A 1 435 ? 170.57600 357.05800 44.63400  1.000 54.26715  ? 470 LYS F O   1 
ATOM   3121 C CB  . LYS A 1 435 ? 167.67700 358.60700 44.33500  1.000 55.91123  ? 470 LYS F CB  1 
ATOM   3122 C CG  . LYS A 1 435 ? 166.19300 358.42500 44.01800  1.000 57.65895  ? 470 LYS F CG  1 
ATOM   3123 C CD  . LYS A 1 435 ? 165.32700 359.04300 45.08900  1.000 69.53249  ? 470 LYS F CD  1 
ATOM   3124 C CE  . LYS A 1 435 ? 164.30400 359.99500 44.47200  1.000 74.65666  ? 470 LYS F CE  1 
ATOM   3125 N NZ  . LYS A 1 435 ? 163.45600 360.66300 45.49700  1.000 81.79570  ? 470 LYS F NZ  1 
ATOM   3126 N N   . GLY A 1 436 ? 170.70600 358.97100 43.45500  1.000 48.28731  ? 471 GLY F N   1 
ATOM   3127 C CA  . GLY A 1 436 ? 172.07400 359.21400 43.83100  1.000 44.39566  ? 471 GLY F CA  1 
ATOM   3128 C C   . GLY A 1 436 ? 172.60100 360.44800 43.14100  1.000 49.14317  ? 471 GLY F C   1 
ATOM   3129 O O   . GLY A 1 436 ? 172.09800 360.86200 42.09500  1.000 53.34551  ? 471 GLY F O   1 
ATOM   3130 N N   . GLU A 1 437 ? 173.57600 361.06600 43.75500  1.000 47.12411  ? 472 GLU F N   1 
ATOM   3131 C CA  . GLU A 1 437 ? 174.17500 362.27000 43.20800  1.000 54.39084  ? 472 GLU F CA  1 
ATOM   3132 C C   . GLU A 1 437 ? 174.92100 361.97200 41.90800  1.000 49.70637  ? 472 GLU F C   1 
ATOM   3133 O O   . GLU A 1 437 ? 175.74600 361.05700 41.87100  1.000 47.71883  ? 472 GLU F O   1 
ATOM   3134 C CB  . GLU A 1 437 ? 175.11900 362.84800 44.24800  1.000 55.22647  ? 472 GLU F CB  1 
ATOM   3135 C CG  . GLU A 1 437 ? 175.89800 364.05200 43.79600  1.000 62.67018  ? 472 GLU F CG  1 
ATOM   3136 C CD  . GLU A 1 437 ? 175.18400 365.35000 43.98500  1.000 67.32338  ? 472 GLU F CD  1 
ATOM   3137 O OE1 . GLU A 1 437 ? 173.93900 365.37100 43.84000  1.000 70.53606  ? 472 GLU F OE1 1 
ATOM   3138 O OE2 . GLU A 1 437 ? 175.88500 366.34700 44.27800  1.000 66.88670  ? 472 GLU F OE2 1 
ATOM   3139 N N   . PRO A 1 438 ? 174.68400 362.72100 40.83400  1.000 50.24978  ? 473 PRO F N   1 
ATOM   3140 C CA  . PRO A 1 438 ? 175.46400 362.47900 39.61300  1.000 46.63122  ? 473 PRO F CA  1 
ATOM   3141 C C   . PRO A 1 438 ? 176.94800 362.66800 39.88800  1.000 49.98389  ? 473 PRO F C   1 
ATOM   3142 O O   . PRO A 1 438 ? 177.38700 363.73600 40.32900  1.000 47.90600  ? 473 PRO F O   1 
ATOM   3143 C CB  . PRO A 1 438 ? 174.93600 363.54900 38.64600  1.000 47.08681  ? 473 PRO F CB  1 
ATOM   3144 C CG  . PRO A 1 438 ? 173.54300 363.88500 39.18200  1.000 50.74865  ? 473 PRO F CG  1 
ATOM   3145 C CD  . PRO A 1 438 ? 173.66000 363.77100 40.65900  1.000 53.91599  ? 473 PRO F CD  1 
ATOM   3146 N N   . ILE A 1 439 ? 177.73600 361.63100 39.57100  1.000 47.74228  ? 474 ILE F N   1 
ATOM   3147 C CA  . ILE A 1 439 ? 179.15500 361.67700 39.92400  1.000 45.73558  ? 474 ILE F CA  1 
ATOM   3148 C C   . ILE A 1 439 ? 179.91200 362.73300 39.15500  1.000 44.70424  ? 474 ILE F C   1 
ATOM   3149 O O   . ILE A 1 439 ? 180.98300 363.16800 39.60400  1.000 49.09975  ? 474 ILE F O   1 
ATOM   3150 C CB  . ILE A 1 439 ? 179.88200 360.33100 39.73800  1.000 45.20320  ? 474 ILE F CB  1 
ATOM   3151 C CG1 . ILE A 1 439 ? 179.99100 359.98100 38.24500  1.000 42.75441  ? 474 ILE F CG1 1 
ATOM   3152 C CG2 . ILE A 1 439 ? 179.21500 359.22400 40.54400  1.000 38.45576  ? 474 ILE F CG2 1 
ATOM   3153 C CD1 . ILE A 1 439 ? 180.75900 358.71500 38.02000  1.000 45.16399  ? 474 ILE F CD1 1 
ATOM   3154 N N   . ILE A 1 440 ? 179.32400 363.25700 38.08100  1.000 44.64196  ? 475 ILE F N   1 
ATOM   3155 C CA  . ILE A 1 440 ? 180.01600 364.29700 37.33900  1.000 45.46644  ? 475 ILE F CA  1 
ATOM   3156 C C   . ILE A 1 440 ? 180.13000 365.55300 38.18700  1.000 44.09239  ? 475 ILE F C   1 
ATOM   3157 O O   . ILE A 1 440 ? 180.96500 366.41900 37.89800  1.000 49.14027  ? 475 ILE F O   1 
ATOM   3158 C CB  . ILE A 1 440 ? 179.28400 364.57800 36.01200  1.000 41.80508  ? 475 ILE F CB  1 
ATOM   3159 C CG1 . ILE A 1 440 ? 180.14000 365.40900 35.05800  1.000 39.90479  ? 475 ILE F CG1 1 
ATOM   3160 C CG2 . ILE A 1 440 ? 177.90400 365.24300 36.27200  1.000 42.27708  ? 475 ILE F CG2 1 
ATOM   3161 C CD1 . ILE A 1 440 ? 181.44300 364.73300 34.63600  1.000 42.04255  ? 475 ILE F CD1 1 
ATOM   3162 N N   . ASN A 1 441 ? 179.28400 365.69800 39.20400  1.000 48.13082  ? 476 ASN F N   1 
ATOM   3163 C CA  . ASN A 1 441 ? 179.36300 366.86700 40.08200  1.000 56.78675  ? 476 ASN F CA  1 
ATOM   3164 C C   . ASN A 1 441 ? 180.52500 366.81900 41.06400  1.000 54.51723  ? 476 ASN F C   1 
ATOM   3165 O O   . ASN A 1 441 ? 180.81100 367.84700 41.68600  1.000 58.45002  ? 476 ASN F O   1 
ATOM   3166 C CB  . ASN A 1 441 ? 178.10800 367.01300 40.94300  1.000 51.03965  ? 476 ASN F CB  1 
ATOM   3167 C CG  . ASN A 1 441 ? 176.86700 367.21200 40.15700  1.000 47.70924  ? 476 ASN F CG  1 
ATOM   3168 O OD1 . ASN A 1 441 ? 176.88100 367.71700 39.03000  1.000 56.99401  ? 476 ASN F OD1 1 
ATOM   3169 N ND2 . ASN A 1 441 ? 175.76100 366.80200 40.74400  1.000 56.31517  ? 476 ASN F ND2 1 
ATOM   3170 N N   . PHE A 1 442 ? 181.19900 365.68000 41.21500  1.000 52.44337  ? 477 PHE F N   1 
ATOM   3171 C CA  . PHE A 1 442 ? 182.32900 365.57600 42.13600  1.000 53.31261  ? 477 PHE F CA  1 
ATOM   3172 C C   . PHE A 1 442 ? 183.62500 366.04400 41.52800  1.000 55.65760  ? 477 PHE F C   1 
ATOM   3173 O O   . PHE A 1 442 ? 184.65500 366.01900 42.20200  1.000 56.62478  ? 477 PHE F O   1 
ATOM   3174 C CB  . PHE A 1 442 ? 182.51500 364.12200 42.58900  1.000 45.63552  ? 477 PHE F CB  1 
ATOM   3175 C CG  . PHE A 1 442 ? 181.32300 363.55000 43.29500  1.000 52.70569  ? 477 PHE F CG  1 
ATOM   3176 C CD1 . PHE A 1 442 ? 180.50500 364.35700 44.06300  1.000 53.66565  ? 477 PHE F CD1 1 
ATOM   3177 C CD2 . PHE A 1 442 ? 181.01200 362.20000 43.18100  1.000 52.52933  ? 477 PHE F CD2 1 
ATOM   3178 C CE1 . PHE A 1 442 ? 179.40100 363.83100 44.73000  1.000 56.73301  ? 477 PHE F CE1 1 
ATOM   3179 C CE2 . PHE A 1 442 ? 179.90100 361.66500 43.83400  1.000 53.59782  ? 477 PHE F CE2 1 
ATOM   3180 C CZ  . PHE A 1 442 ? 179.09400 362.48700 44.61500  1.000 52.56805  ? 477 PHE F CZ  1 
ATOM   3181 N N   . TYR A 1 443 ? 183.59100 366.57300 40.31800  1.000 55.68748  ? 478 TYR F N   1 
ATOM   3182 C CA  . TYR A 1 443 ? 184.80700 366.88100 39.59600  1.000 53.63072  ? 478 TYR F CA  1 
ATOM   3183 C C   . TYR A 1 443 ? 184.93400 368.38000 39.42600  1.000 59.15160  ? 478 TYR F C   1 
ATOM   3184 O O   . TYR A 1 443 ? 183.95400 369.05200 39.07000  1.000 57.59042  ? 478 TYR F O   1 
ATOM   3185 C CB  . TYR A 1 443 ? 184.77000 366.21700 38.21200  1.000 50.25233  ? 478 TYR F CB  1 
ATOM   3186 C CG  . TYR A 1 443 ? 184.94600 364.72700 38.33200  1.000 54.42265  ? 478 TYR F CG  1 
ATOM   3187 C CD1 . TYR A 1 443 ? 186.16900 364.15800 38.65100  1.000 49.49156  ? 478 TYR F CD1 1 
ATOM   3188 C CD2 . TYR A 1 443 ? 183.84800 363.89700 38.20500  1.000 51.41843  ? 478 TYR F CD2 1 
ATOM   3189 C CE1 . TYR A 1 443 ? 186.29200 362.80900 38.79100  1.000 44.77627  ? 478 TYR F CE1 1 
ATOM   3190 C CE2 . TYR A 1 443 ? 183.95900 362.53800 38.34700  1.000 49.90814  ? 478 TYR F CE2 1 
ATOM   3191 C CZ  . TYR A 1 443 ? 185.18000 362.00500 38.65200  1.000 51.91475  ? 478 TYR F CZ  1 
ATOM   3192 O OH  . TYR A 1 443 ? 185.26800 360.64800 38.78400  1.000 59.26443  ? 478 TYR F OH  1 
ATOM   3193 N N   . ASP A 1 444 ? 186.11800 368.89800 39.72500  1.000 55.43604  ? 479 ASP F N   1 
ATOM   3194 C CA  . ASP A 1 444 ? 186.37300 370.29800 39.46800  1.000 60.99305  ? 479 ASP F CA  1 
ATOM   3195 C C   . ASP A 1 444 ? 186.52700 370.43800 37.95900  1.000 60.85805  ? 479 ASP F C   1 
ATOM   3196 O O   . ASP A 1 444 ? 187.38100 369.77100 37.37300  1.000 62.52675  ? 479 ASP F O   1 
ATOM   3197 C CB  . ASP A 1 444 ? 187.65600 370.69700 40.19600  1.000 63.59260  ? 479 ASP F CB  1 
ATOM   3198 C CG  . ASP A 1 444 ? 188.06700 372.13100 39.95000  1.000 68.34775  ? 479 ASP F CG  1 
ATOM   3199 O OD1 . ASP A 1 444 ? 187.33000 372.87800 39.26800  1.000 69.24416  ? 479 ASP F OD1 1 
ATOM   3200 O OD2 . ASP A 1 444 ? 189.17200 372.49700 40.41700  1.000 75.24793  ? 479 ASP F OD2 1 
ATOM   3201 N N   . PRO A 1 445 ? 185.76700 371.32200 37.30800  1.000 57.46142  ? 480 PRO F N   1 
ATOM   3202 C CA  . PRO A 1 445 ? 185.83600 371.39700 35.84100  1.000 57.81830  ? 480 PRO F CA  1 
ATOM   3203 C C   . PRO A 1 445 ? 187.19300 371.80300 35.31500  1.000 67.28969  ? 480 PRO F C   1 
ATOM   3204 O O   . PRO A 1 445 ? 187.59400 371.35200 34.23300  1.000 68.37492  ? 480 PRO F O   1 
ATOM   3205 C CB  . PRO A 1 445 ? 184.76100 372.43000 35.50200  1.000 61.00125  ? 480 PRO F CB  1 
ATOM   3206 C CG  . PRO A 1 445 ? 183.78700 372.34500 36.61300  1.000 60.43796  ? 480 PRO F CG  1 
ATOM   3207 C CD  . PRO A 1 445 ? 184.39300 371.55200 37.75800  1.000 60.62109  ? 480 PRO F CD  1 
ATOM   3208 N N   . LEU A 1 446 ? 187.87800 372.71100 36.00800  1.000 67.13799  ? 481 LEU F N   1 
ATOM   3209 C CA  . LEU A 1 446 ? 189.12300 373.25100 35.48400  1.000 67.54785  ? 481 LEU F CA  1 
ATOM   3210 C C   . LEU A 1 446 ? 190.13500 372.14000 35.26700  1.000 68.40469  ? 481 LEU F C   1 
ATOM   3211 O O   . LEU A 1 446 ? 190.92600 372.21200 34.32400  1.000 72.44391  ? 481 LEU F O   1 
ATOM   3212 C CB  . LEU A 1 446 ? 189.66400 374.34900 36.40400  1.000 72.85881  ? 481 LEU F CB  1 
ATOM   3213 C CG  . LEU A 1 446 ? 188.67000 375.48700 36.67200  1.000 68.35254  ? 481 LEU F CG  1 
ATOM   3214 C CD1 . LEU A 1 446 ? 188.00900 375.91100 35.36900  1.000 69.29754  ? 481 LEU F CD1 1 
ATOM   3215 C CD2 . LEU A 1 446 ? 187.60200 375.12600 37.70700  1.000 74.73107  ? 481 LEU F CD2 1 
ATOM   3216 N N   . VAL A 1 447 ? 190.21600 371.16500 36.17800  1.000 63.33916  ? 482 VAL F N   1 
ATOM   3217 C CA  . VAL A 1 447 ? 191.23300 370.13700 36.01000  1.000 67.19911  ? 482 VAL F CA  1 
ATOM   3218 C C   . VAL A 1 447 ? 190.65400 368.82100 35.47400  1.000 64.23396  ? 482 VAL F C   1 
ATOM   3219 O O   . VAL A 1 447 ? 191.36400 367.80700 35.46400  1.000 62.25040  ? 482 VAL F O   1 
ATOM   3220 C CB  . VAL A 1 447 ? 191.99900 369.88600 37.32600  1.000 70.37835  ? 482 VAL F CB  1 
ATOM   3221 C CG1 . VAL A 1 447 ? 192.81600 371.13000 37.72300  1.000 81.08459  ? 482 VAL F CG1 1 
ATOM   3222 C CG2 . VAL A 1 447 ? 191.04700 369.45100 38.43100  1.000 66.12996  ? 482 VAL F CG2 1 
ATOM   3223 N N   . PHE A 1 448 ? 189.38800 368.80100 35.03400  1.000 58.68619  ? 483 PHE F N   1 
ATOM   3224 C CA  . PHE A 1 448 ? 188.79700 367.54100 34.55600  1.000 56.75862  ? 483 PHE F CA  1 
ATOM   3225 C C   . PHE A 1 448 ? 189.48200 367.15600 33.24000  1.000 47.92356  ? 483 PHE F C   1 
ATOM   3226 O O   . PHE A 1 448 ? 189.48400 367.96800 32.30800  1.000 49.60559  ? 483 PHE F O   1 
ATOM   3227 C CB  . PHE A 1 448 ? 187.27900 367.74600 34.35500  1.000 52.41512  ? 483 PHE F CB  1 
ATOM   3228 C CG  . PHE A 1 448 ? 186.49800 366.47400 34.12100  1.000 50.36896  ? 483 PHE F CG  1 
ATOM   3229 C CD1 . PHE A 1 448 ? 186.45600 365.47000 35.07200  1.000 44.97819  ? 483 PHE F CD1 1 
ATOM   3230 C CD2 . PHE A 1 448 ? 185.87200 366.25900 32.89300  1.000 46.50040  ? 483 PHE F CD2 1 
ATOM   3231 C CE1 . PHE A 1 448 ? 185.74500 364.29900 34.82900  1.000 48.93273  ? 483 PHE F CE1 1 
ATOM   3232 C CE2 . PHE A 1 448 ? 185.18400 365.07600 32.62500  1.000 44.49681  ? 483 PHE F CE2 1 
ATOM   3233 C CZ  . PHE A 1 448 ? 185.11900 364.09400 33.59300  1.000 47.44378  ? 483 PHE F CZ  1 
ATOM   3234 N N   . PRO A 1 449 ? 189.83800 365.87400 33.01600  1.000 47.00947  ? 484 PRO F N   1 
ATOM   3235 C CA  . PRO A 1 449 ? 190.31300 365.50600 31.65500  1.000 49.68074  ? 484 PRO F CA  1 
ATOM   3236 C C   . PRO A 1 449 ? 189.08000 365.31100 30.80000  1.000 45.27453  ? 484 PRO F C   1 
ATOM   3237 O O   . PRO A 1 449 ? 188.46600 364.24000 30.86400  1.000 48.35460  ? 484 PRO F O   1 
ATOM   3238 C CB  . PRO A 1 449 ? 191.04600 364.17400 31.86700  1.000 48.97997  ? 484 PRO F CB  1 
ATOM   3239 C CG  . PRO A 1 449 ? 191.12300 363.99100 33.33800  1.000 52.60917  ? 484 PRO F CG  1 
ATOM   3240 C CD  . PRO A 1 449 ? 189.97000 364.75200 33.94500  1.000 49.77176  ? 484 PRO F CD  1 
ATOM   3241 N N   . SER A 1 450 ? 188.75200 366.27300 29.94200  1.000 47.53233  ? 485 SER F N   1 
ATOM   3242 C CA  . SER A 1 450 ? 187.47200 366.24300 29.24200  1.000 48.75293  ? 485 SER F CA  1 
ATOM   3243 C C   . SER A 1 450 ? 187.47700 365.66500 27.82800  1.000 53.00371  ? 485 SER F C   1 
ATOM   3244 O O   . SER A 1 450 ? 186.52600 365.90500 27.06700  1.000 53.75237  ? 485 SER F O   1 
ATOM   3245 C CB  . SER A 1 450 ? 186.88700 367.65400 29.26000  1.000 47.66869  ? 485 SER F CB  1 
ATOM   3246 O OG  . SER A 1 450 ? 187.77100 368.52700 28.60100  1.000 58.03229  ? 485 SER F OG  1 
ATOM   3247 N N   . ASP A 1 451 ? 188.51800 364.96600 27.42100  1.000 47.19295  ? 486 ASP F N   1 
ATOM   3248 C CA  . ASP A 1 451 ? 188.53400 364.40700 26.06500  1.000 49.26472  ? 486 ASP F CA  1 
ATOM   3249 C C   . ASP A 1 451 ? 189.11300 363.00800 26.11500  1.000 48.82599  ? 486 ASP F C   1 
ATOM   3250 O O   . ASP A 1 451 ? 189.91200 362.62200 25.26100  1.000 46.58091  ? 486 ASP F O   1 
ATOM   3251 C CB  . ASP A 1 451 ? 189.24300 365.28000 25.03300  1.000 47.21510  ? 486 ASP F CB  1 
ATOM   3252 C CG  . ASP A 1 451 ? 188.82100 364.91500 23.58800  1.000 51.67206  ? 486 ASP F CG  1 
ATOM   3253 O OD1 . ASP A 1 451 ? 187.93200 364.06300 23.43100  1.000 47.64589  ? 486 ASP F OD1 1 
ATOM   3254 O OD2 . ASP A 1 451 ? 189.38100 365.45000 22.60100  1.000 52.68940  ? 486 ASP F OD2 1 
ATOM   3255 N N   . GLU A 1 452 ? 188.81900 362.26000 27.16600  1.000 47.41880  ? 487 GLU F N   1 
ATOM   3256 C CA  . GLU A 1 452 ? 189.34700 360.91400 27.22500  1.000 44.54879  ? 487 GLU F CA  1 
ATOM   3257 C C   . GLU A 1 452 ? 188.42600 359.95600 26.49900  1.000 43.62278  ? 487 GLU F C   1 
ATOM   3258 O O   . GLU A 1 452 ? 187.24500 359.84000 26.82900  1.000 47.00195  ? 487 GLU F O   1 
ATOM   3259 C CB  . GLU A 1 452 ? 189.46900 360.47000 28.67900  1.000 47.60273  ? 487 GLU F CB  1 
ATOM   3260 C CG  . GLU A 1 452 ? 190.33000 361.38700 29.51300  1.000 50.85752  ? 487 GLU F CG  1 
ATOM   3261 C CD  . GLU A 1 452 ? 191.79600 361.23000 29.19800  1.000 47.40241  ? 487 GLU F CD  1 
ATOM   3262 O OE1 . GLU A 1 452 ? 192.28600 360.11300 29.22200  1.000 53.29582  ? 487 GLU F OE1 1 
ATOM   3263 O OE2 . GLU A 1 452 ? 192.47600 362.24900 29.02500  1.000 54.75062  ? 487 GLU F OE2 1 
ATOM   3264 N N   . PHE A 1 453 ? 189.03900 359.03100 25.80800  1.000 45.92724  ? 488 PHE F N   1 
ATOM   3265 C CA  . PHE A 1 453 ? 188.28600 358.14300 24.95500  1.000 53.47968  ? 488 PHE F CA  1 
ATOM   3266 C C   . PHE A 1 453 ? 188.13000 356.75300 25.53700  1.000 47.14133  ? 488 PHE F C   1 
ATOM   3267 O O   . PHE A 1 453 ? 187.14700 356.08600 25.20800  1.000 49.47663  ? 488 PHE F O   1 
ATOM   3268 C CB  . PHE A 1 453 ? 189.02000 358.14500 23.60200  1.000 53.85991  ? 488 PHE F CB  1 
ATOM   3269 C CG  . PHE A 1 453 ? 189.01700 356.85200 22.85300  1.000 61.37664  ? 488 PHE F CG  1 
ATOM   3270 C CD1 . PHE A 1 453 ? 187.99500 356.54900 21.96100  1.000 65.82378  ? 488 PHE F CD1 1 
ATOM   3271 C CD2 . PHE A 1 453 ? 190.06500 355.96200 22.99600  1.000 60.88844  ? 488 PHE F CD2 1 
ATOM   3272 C CE1 . PHE A 1 453 ? 188.01300 355.36500 21.24000  1.000 71.22280  ? 488 PHE F CE1 1 
ATOM   3273 C CE2 . PHE A 1 453 ? 190.09100 354.78000 22.28800  1.000 61.97377  ? 488 PHE F CE2 1 
ATOM   3274 C CZ  . PHE A 1 453 ? 189.06400 354.47800 21.40500  1.000 68.96738  ? 488 PHE F CZ  1 
ATOM   3275 N N   . ASP A 1 454 ? 188.95800 356.39800 26.51600  1.000 44.67530  ? 489 ASP F N   1 
ATOM   3276 C CA  . ASP A 1 454 ? 188.95300 355.10400 27.19800  1.000 47.97954  ? 489 ASP F CA  1 
ATOM   3277 C C   . ASP A 1 454 ? 189.59400 355.13200 28.56500  1.000 48.34392  ? 489 ASP F C   1 
ATOM   3278 O O   . ASP A 1 454 ? 190.62200 354.49100 28.76700  1.000 57.43571  ? 489 ASP F O   1 
ATOM   3279 C CB  . ASP A 1 454 ? 189.62900 353.98600 26.42800  1.000 52.60309  ? 489 ASP F CB  1 
ATOM   3280 C CG  . ASP A 1 454 ? 189.03800 352.62700 26.79200  1.000 58.85987  ? 489 ASP F CG  1 
ATOM   3281 O OD1 . ASP A 1 454 ? 188.27500 352.57100 27.78600  1.000 61.50733  ? 489 ASP F OD1 1 
ATOM   3282 O OD2 . ASP A 1 454 ? 189.47000 351.60700 26.23600  1.000 60.68052  ? 489 ASP F OD2 1 
ATOM   3283 N N   . ALA A 1 455 ? 189.09100 355.96400 29.45200  1.000 47.68825  ? 490 ALA F N   1 
ATOM   3284 C CA  . ALA A 1 455 ? 189.68400 356.17600 30.75500  1.000 51.89298  ? 490 ALA F CA  1 
ATOM   3285 C C   . ALA A 1 455 ? 188.92200 355.44700 31.86100  1.000 53.95018  ? 490 ALA F C   1 
ATOM   3286 O O   . ALA A 1 455 ? 187.79400 355.00200 31.67800  1.000 62.93401  ? 490 ALA F O   1 
ATOM   3287 C CB  . ALA A 1 455 ? 189.76300 357.66800 31.06700  1.000 50.32988  ? 490 ALA F CB  1 
ATOM   3288 N N   . SER A 1 456 ? 189.66200 355.04100 32.84300  1.000 58.93375  ? 491 SER F N   1 
ATOM   3289 C CA  . SER A 1 456 ? 189.21300 354.42700 34.07700  1.000 57.84566  ? 491 SER F CA  1 
ATOM   3290 C C   . SER A 1 456 ? 188.86500 355.49700 35.10500  1.000 56.40540  ? 491 SER F C   1 
ATOM   3291 O O   . SER A 1 456 ? 189.30100 356.64500 35.01400  1.000 55.95461  ? 491 SER F O   1 
ATOM   3292 C CB  . SER A 1 456 ? 190.26300 353.50200 34.63100  1.000 51.37572  ? 491 SER F CB  1 
ATOM   3293 O OG  . SER A 1 456 ? 191.14400 354.24200 35.45100  1.000 60.31089  ? 491 SER F OG  1 
ATOM   3294 N N   . ILE A 1 457 ? 188.07000 355.11500 36.09400  1.000 54.39382  ? 492 ILE F N   1 
ATOM   3295 C CA  . ILE A 1 457 ? 187.76100 356.05700 37.15900  1.000 51.63759  ? 492 ILE F CA  1 
ATOM   3296 C C   . ILE A 1 457 ? 189.07900 356.47500 37.84000  1.000 58.11453  ? 492 ILE F C   1 
ATOM   3297 O O   . ILE A 1 457 ? 189.35900 357.67000 38.05900  1.000 54.07100  ? 492 ILE F O   1 
ATOM   3298 C CB  . ILE A 1 457 ? 186.83500 355.36800 38.18100  1.000 53.51555  ? 492 ILE F CB  1 
ATOM   3299 C CG1 . ILE A 1 457 ? 185.35500 355.40000 37.76300  1.000 57.46026  ? 492 ILE F CG1 1 
ATOM   3300 C CG2 . ILE A 1 457 ? 187.08800 355.90800 39.59400  1.000 51.69131  ? 492 ILE F CG2 1 
ATOM   3301 C CD1 . ILE A 1 457 ? 184.72600 356.75600 37.78500  1.000 53.29974  ? 492 ILE F CD1 1 
ATOM   3302 N N   . SER A 1 458 ? 189.90000 355.48400 38.22000  1.000 54.23179  ? 493 SER F N   1 
ATOM   3303 C CA  . SER A 1 458 ? 191.19100 355.79200 38.83900  1.000 63.87339  ? 493 SER F CA  1 
ATOM   3304 C C   . SER A 1 458 ? 192.16800 356.45200 37.87400  1.000 62.37294  ? 493 SER F C   1 
ATOM   3305 O O   . SER A 1 458 ? 193.00600 357.25300 38.29000  1.000 61.83522  ? 493 SER F O   1 
ATOM   3306 C CB  . SER A 1 458 ? 191.81600 354.52500 39.42200  1.000 60.41072  ? 493 SER F CB  1 
ATOM   3307 O OG  . SER A 1 458 ? 191.05800 354.08300 40.52500  1.000 67.56767  ? 493 SER F OG  1 
ATOM   3308 N N   . GLN A 1 459 ? 192.06200 356.15700 36.58500  1.000 63.13378  ? 494 GLN F N   1 
ATOM   3309 C CA  . GLN A 1 459 ? 192.93400 356.81800 35.62300  1.000 64.14086  ? 494 GLN F CA  1 
ATOM   3310 C C   . GLN A 1 459 ? 192.60000 358.30900 35.59300  1.000 70.42869  ? 494 GLN F C   1 
ATOM   3311 O O   . GLN A 1 459 ? 193.50400 359.15800 35.53400  1.000 70.34043  ? 494 GLN F O   1 
ATOM   3312 C CB  . GLN A 1 459 ? 192.94400 356.02700 34.31000  1.000 60.87257  ? 494 GLN F CB  1 
ATOM   3313 C CG  . GLN A 1 459 ? 193.49400 356.63800 33.04700  1.000 64.09870  ? 494 GLN F CG  1 
ATOM   3314 C CD  . GLN A 1 459 ? 193.17900 355.75100 31.85300  1.000 65.35425  ? 494 GLN F CD  1 
ATOM   3315 O OE1 . GLN A 1 459 ? 192.80700 354.58100 32.02400  1.000 67.10113  ? 494 GLN F OE1 1 
ATOM   3316 N NE2 . GLN A 1 459 ? 193.44300 356.24700 30.65000  1.000 66.15869  ? 494 GLN F NE2 1 
ATOM   3317 N N   . VAL A 1 460 ? 191.30500 358.65000 35.61800  1.000 68.28870  ? 495 VAL F N   1 
ATOM   3318 C CA  . VAL A 1 460 ? 190.93200 360.06000 35.60300  1.000 63.23158  ? 495 VAL F CA  1 
ATOM   3319 C C   . VAL A 1 460 ? 191.39300 360.69300 36.91500  1.000 66.39346  ? 495 VAL F C   1 
ATOM   3320 O O   . VAL A 1 460 ? 191.79800 361.86300 36.94500  1.000 67.41288  ? 495 VAL F O   1 
ATOM   3321 C CB  . VAL A 1 460 ? 189.41700 360.24400 35.38700  1.000 54.46060  ? 495 VAL F CB  1 
ATOM   3322 C CG1 . VAL A 1 460 ? 189.04100 361.70000 35.51300  1.000 51.91923  ? 495 VAL F CG1 1 
ATOM   3323 C CG2 . VAL A 1 460 ? 189.02000 359.76600 34.03200  1.000 55.52867  ? 495 VAL F CG2 1 
ATOM   3324 N N   . ASN A 1 461 ? 191.25500 359.97400 38.04000  1.000 64.97029  ? 496 ASN F N   1 
ATOM   3325 C CA  . ASN A 1 461 ? 191.70100 360.56600 39.30400  1.000 70.88987  ? 496 ASN F CA  1 
ATOM   3326 C C   . ASN A 1 461 ? 193.21300 360.81000 39.33000  1.000 79.24461  ? 496 ASN F C   1 
ATOM   3327 O O   . ASN A 1 461 ? 193.66700 361.83500 39.84700  1.000 83.15047  ? 496 ASN F O   1 
ATOM   3328 C CB  . ASN A 1 461 ? 191.34000 359.69300 40.50000  1.000 64.61930  ? 496 ASN F CB  1 
ATOM   3329 C CG  . ASN A 1 461 ? 189.88900 359.73300 40.84400  1.000 70.63476  ? 496 ASN F CG  1 
ATOM   3330 O OD1 . ASN A 1 461 ? 189.17700 360.66900 40.48300  1.000 74.02209  ? 496 ASN F OD1 1 
ATOM   3331 N ND2 . ASN A 1 461 ? 189.43300 358.72500 41.58200  1.000 69.84850  ? 496 ASN F ND2 1 
ATOM   3332 N N   . GLU A 1 462 ? 194.01600 359.89900 38.76500  1.000 77.58798  ? 497 GLU F N   1 
ATOM   3333 C CA  . GLU A 1 462 ? 195.46000 360.15300 38.73200  1.000 85.11263  ? 497 GLU F CA  1 
ATOM   3334 C C   . GLU A 1 462 ? 195.82400 361.29800 37.79400  1.000 85.93724  ? 497 GLU F C   1 
ATOM   3335 O O   . GLU A 1 462 ? 196.73800 362.08500 38.08000  1.000 90.38279  ? 497 GLU F O   1 
ATOM   3336 C CB  . GLU A 1 462 ? 196.25400 358.89700 38.31400  1.000 85.30119  ? 497 GLU F CB  1 
ATOM   3337 C CG  . GLU A 1 462 ? 196.23500 358.60000 36.79900  1.000 86.95951  ? 497 GLU F CG  1 
ATOM   3338 C CD  . GLU A 1 462 ? 196.69300 357.17400 36.38400  1.000 92.84681  ? 497 GLU F CD  1 
ATOM   3339 O OE1 . GLU A 1 462 ? 196.78000 356.25000 37.24400  1.000 91.11227  ? 497 GLU F OE1 1 
ATOM   3340 O OE2 . GLU A 1 462 ? 196.93300 356.98900 35.15800  1.000 84.26722  ? 497 GLU F OE2 1 
ATOM   3341 N N   . LYS A 1 463 ? 195.12100 361.41300 36.67100  1.000 82.97695  ? 498 LYS F N   1 
ATOM   3342 C CA  . LYS A 1 463 ? 195.36700 362.53400 35.77300  1.000 83.84550  ? 498 LYS F CA  1 
ATOM   3343 C C   . LYS A 1 463 ? 194.95100 363.85900 36.43500  1.000 85.77770  ? 498 LYS F C   1 
ATOM   3344 O O   . LYS A 1 463 ? 195.59500 364.89900 36.21800  1.000 89.81910  ? 498 LYS F O   1 
ATOM   3345 C CB  . LYS A 1 463 ? 194.74300 362.17500 34.42000  1.000 74.87615  ? 498 LYS F CB  1 
ATOM   3346 C CG  . LYS A 1 463 ? 195.00200 363.07800 33.25200  1.000 74.34254  ? 498 LYS F CG  1 
ATOM   3347 C CD  . LYS A 1 463 ? 194.90600 362.12100 32.01700  1.000 67.54000  ? 498 LYS F CD  1 
ATOM   3348 C CE  . LYS A 1 463 ? 195.05300 362.77300 30.64200  1.000 67.23343  ? 498 LYS F CE  1 
ATOM   3349 N NZ  . LYS A 1 463 ? 195.81900 364.06300 30.65700  1.000 72.72980  ? 498 LYS F NZ  1 
ATOM   3350 N N   . ILE A 1 464 ? 193.97100 363.80900 37.34900  1.000 83.14115  ? 499 ILE F N   1 
ATOM   3351 C CA  . ILE A 1 464 ? 193.57000 365.00400 38.09000  1.000 85.12323  ? 499 ILE F CA  1 
ATOM   3352 C C   . ILE A 1 464 ? 194.60300 365.32100 39.15800  1.000 89.81343  ? 499 ILE F C   1 
ATOM   3353 O O   . ILE A 1 464 ? 194.87300 366.48900 39.44400  1.000 92.34874  ? 499 ILE F O   1 
ATOM   3354 C CB  . ILE A 1 464 ? 192.17400 364.84100 38.72600  1.000 79.01199  ? 499 ILE F CB  1 
ATOM   3355 C CG1 . ILE A 1 464 ? 191.08600 364.63000 37.67300  1.000 71.45537  ? 499 ILE F CG1 1 
ATOM   3356 C CG2 . ILE A 1 464 ? 191.87800 365.99200 39.67900  1.000 80.35499  ? 499 ILE F CG2 1 
ATOM   3357 C CD1 . ILE A 1 464 ? 189.70400 364.44100 38.26700  1.000 54.93173  ? 499 ILE F CD1 1 
ATOM   3358 N N   . ASN A 1 465 ? 195.18700 364.28900 39.76500  1.000 92.51699  ? 500 ASN F N   1 
ATOM   3359 C CA  . ASN A 1 465 ? 196.24500 364.48700 40.75200  1.000 95.76703  ? 500 ASN F CA  1 
ATOM   3360 C C   . ASN A 1 465 ? 197.48100 365.10800 40.10900  1.000 96.83818  ? 500 ASN F C   1 
ATOM   3361 O O   . ASN A 1 465 ? 198.12800 365.97900 40.70600  1.000 99.13742  ? 500 ASN F O   1 
ATOM   3362 C CB  . ASN A 1 465 ? 196.65900 363.11700 41.28200  1.000 95.23331  ? 500 ASN F CB  1 
ATOM   3363 C CG  . ASN A 1 465 ? 195.69000 362.53000 42.27000  1.000 100.01989 ? 500 ASN F CG  1 
ATOM   3364 O OD1 . ASN A 1 465 ? 194.54600 362.96600 42.38700  1.000 99.68216  ? 500 ASN F OD1 1 
ATOM   3365 N ND2 . ASN A 1 465 ? 196.12000 361.44900 42.91600  1.000 107.82019 ? 500 ASN F ND2 1 
ATOM   3366 N N   . GLN A 1 466 ? 197.73000 364.77700 38.83600  1.000 97.23494  ? 501 GLN F N   1 
ATOM   3367 C CA  . GLN A 1 466 ? 198.85100 365.35300 38.09600  1.000 100.78721 ? 501 GLN F CA  1 
ATOM   3368 C C   . GLN A 1 466 ? 198.56300 366.77900 37.65100  1.000 108.75575 ? 501 GLN F C   1 
ATOM   3369 O O   . GLN A 1 466 ? 199.45900 367.64400 37.68400  1.000 116.22483 ? 501 GLN F O   1 
ATOM   3370 C CB  . GLN A 1 466 ? 199.12400 364.51200 36.85400  1.000 99.25249  ? 501 GLN F CB  1 
ATOM   3371 C CG  . GLN A 1 466 ? 199.58100 363.09700 37.10700  1.000 102.20712 ? 501 GLN F CG  1 
ATOM   3372 C CD  . GLN A 1 466 ? 199.74400 362.33700 35.80900  1.000 105.54897 ? 501 GLN F CD  1 
ATOM   3373 O OE1 . GLN A 1 466 ? 199.73900 362.93500 34.73200  1.000 108.65888 ? 501 GLN F OE1 1 
ATOM   3374 N NE2 . GLN A 1 466 ? 199.85100 361.01600 35.89600  1.000 100.78125 ? 501 GLN F NE2 1 
ATOM   3375 N N   . SER A 1 467 ? 197.29700 367.07400 37.35200  1.000 105.14057 ? 502 SER F N   1 
ATOM   3376 C CA  . SER A 1 467 ? 196.97000 368.43700 36.96800  1.000 106.88727 ? 502 SER F CA  1 
ATOM   3377 C C   . SER A 1 467 ? 196.90300 369.31800 38.20200  1.000 111.36147 ? 502 SER F C   1 
ATOM   3378 O O   . SER A 1 467 ? 197.06700 370.54000 38.09100  1.000 113.28716 ? 502 SER F O   1 
ATOM   3379 C CB  . SER A 1 467 ? 195.65700 368.48700 36.18200  1.000 94.59920  ? 502 SER F CB  1 
ATOM   3380 O OG  . SER A 1 467 ? 195.75200 367.75000 34.97400  1.000 96.57352  ? 502 SER F OG  1 
ATOM   3381 N N   . LEU A 1 468 ? 196.65500 368.71300 39.37100  1.000 106.55799 ? 503 LEU F N   1 
ATOM   3382 C CA  . LEU A 1 468 ? 196.68800 369.47000 40.60700  1.000 107.97228 ? 503 LEU F CA  1 
ATOM   3383 C C   . LEU A 1 468 ? 198.12700 369.70000 41.03600  1.000 117.37209 ? 503 LEU F C   1 
ATOM   3384 O O   . LEU A 1 468 ? 198.40300 370.68200 41.73200  1.000 122.30125 ? 503 LEU F O   1 
ATOM   3385 C CB  . LEU A 1 468 ? 195.94400 368.70700 41.70500  1.000 100.85375 ? 503 LEU F CB  1 
ATOM   3386 C CG  . LEU A 1 468 ? 194.41700 368.69200 41.67700  1.000 97.24945  ? 503 LEU F CG  1 
ATOM   3387 C CD1 . LEU A 1 468 ? 193.86700 367.87900 42.83900  1.000 96.65885  ? 503 LEU F CD1 1 
ATOM   3388 C CD2 . LEU A 1 468 ? 193.88300 370.11000 41.71400  1.000 92.75332  ? 503 LEU F CD2 1 
ATOM   3389 N N   . ALA A 1 469 ? 199.05000 368.79100 40.67600  1.000 117.40950 ? 504 ALA F N   1 
ATOM   3390 C CA  . ALA A 1 469 ? 200.45800 369.06600 40.96100  1.000 121.97986 ? 504 ALA F CA  1 
ATOM   3391 C C   . ALA A 1 469 ? 201.02500 370.18400 40.08000  1.000 127.84586 ? 504 ALA F C   1 
ATOM   3392 O O   . ALA A 1 469 ? 201.89300 370.94100 40.53500  1.000 132.46312 ? 504 ALA F O   1 
ATOM   3393 C CB  . ALA A 1 469 ? 201.29200 367.79600 40.79100  1.000 114.54828 ? 504 ALA F CB  1 
ATOM   3394 N N   . PHE A 1 470 ? 200.55500 370.31400 38.82500  1.000 126.67693 ? 505 PHE F N   1 
ATOM   3395 C CA  . PHE A 1 470 ? 201.02800 371.43200 37.98700  1.000 130.49273 ? 505 PHE F CA  1 
ATOM   3396 C C   . PHE A 1 470 ? 200.53000 372.80800 38.44100  1.000 132.21520 ? 505 PHE F C   1 
ATOM   3397 O O   . PHE A 1 470 ? 201.12900 373.82200 38.06200  1.000 131.68824 ? 505 PHE F O   1 
ATOM   3398 C CB  . PHE A 1 470 ? 200.67400 371.24200 36.50300  1.000 132.81344 ? 505 PHE F CB  1 
ATOM   3399 C CG  . PHE A 1 470 ? 201.25100 369.99500 35.87900  1.000 133.51112 ? 505 PHE F CG  1 
ATOM   3400 C CD1 . PHE A 1 470 ? 202.46000 369.47400 36.32500  1.000 131.66331 ? 505 PHE F CD1 1 
ATOM   3401 C CD2 . PHE A 1 470 ? 200.59600 369.36300 34.82500  1.000 133.22594 ? 505 PHE F CD2 1 
ATOM   3402 C CE1 . PHE A 1 470 ? 202.99900 368.33500 35.74300  1.000 133.66920 ? 505 PHE F CE1 1 
ATOM   3403 C CE2 . PHE A 1 470 ? 201.12700 368.22000 34.23900  1.000 133.25952 ? 505 PHE F CE2 1 
ATOM   3404 C CZ  . PHE A 1 470 ? 202.32900 367.70500 34.69900  1.000 134.35410 ? 505 PHE F CZ  1 
ATOM   3405 N N   . ILE A 1 471 ? 199.45700 372.86700 39.23500  1.000 131.58234 ? 506 ILE F N   1 
ATOM   3406 C CA  . ILE A 1 471 ? 198.90700 374.11800 39.75700  1.000 131.62075 ? 506 ILE F CA  1 
ATOM   3407 C C   . ILE A 1 471 ? 199.39800 374.34100 41.18100  1.000 133.76537 ? 506 ILE F C   1 
ATOM   3408 O O   . ILE A 1 471 ? 199.48600 375.48100 41.65500  1.000 135.41548 ? 506 ILE F O   1 
ATOM   3409 C CB  . ILE A 1 471 ? 197.36600 374.12000 39.67600  1.000 125.39860 ? 506 ILE F CB  1 
ATOM   3410 C CG1 . ILE A 1 471 ? 196.90900 373.68800 38.27600  1.000 122.39776 ? 506 ILE F CG1 1 
ATOM   3411 C CG2 . ILE A 1 471 ? 196.80400 375.48900 40.02400  1.000 122.86179 ? 506 ILE F CG2 1 
ATOM   3412 C CD1 . ILE A 1 471 ? 195.40400 373.62900 38.10400  1.000 112.95414 ? 506 ILE F CD1 1 
ATOM   3413 N N   . ARG A 1 472 ? 199.70900 373.24100 41.87000  1.000 132.66393 ? 507 ARG F N   1 
ATOM   3414 C CA  . ARG A 1 472 ? 200.19600 373.30300 43.24500  1.000 134.46758 ? 507 ARG F CA  1 
ATOM   3415 C C   . ARG A 1 472 ? 201.54300 374.01100 43.31500  1.000 138.69874 ? 507 ARG F C   1 
ATOM   3416 O O   . ARG A 1 472 ? 201.77300 374.84500 44.20100  1.000 138.31283 ? 507 ARG F O   1 
ATOM   3417 C CB  . ARG A 1 472 ? 200.27700 371.89300 43.83100  1.000 133.33905 ? 507 ARG F CB  1 
ATOM   3418 C CG  . ARG A 1 472 ? 198.96000 371.41800 44.44600  1.000 132.96814 ? 507 ARG F CG  1 
ATOM   3419 C CD  . ARG A 1 472 ? 199.19100 370.70500 45.76100  1.000 137.37075 ? 507 ARG F CD  1 
ATOM   3420 N NE  . ARG A 1 472 ? 199.82400 371.58100 46.74100  1.000 141.03675 ? 507 ARG F NE  1 
ATOM   3421 C CZ  . ARG A 1 472 ? 201.01400 371.35900 47.28800  1.000 139.20468 ? 507 ARG F CZ  1 
ATOM   3422 N NH1 . ARG A 1 472 ? 201.73300 370.29400 46.97300  1.000 137.08628 ? 507 ARG F NH1 1 
ATOM   3423 N NH2 . ARG A 1 472 ? 201.49700 372.23200 48.16800  1.000 137.44385 ? 507 ARG F NH2 1 
ATOM   3424 N N   . LYS A 1 473 ? 202.45300 373.68300 42.39100  1.000 140.11550 ? 508 LYS F N   1 
ATOM   3425 C CA  . LYS A 1 473 ? 203.77200 374.30800 42.38300  1.000 140.02850 ? 508 LYS F CA  1 
ATOM   3426 C C   . LYS A 1 473 ? 203.69600 375.79600 42.05200  1.000 141.18703 ? 508 LYS F C   1 
ATOM   3427 O O   . LYS A 1 473 ? 204.54400 376.57100 42.51200  1.000 143.21583 ? 508 LYS F O   1 
ATOM   3428 C CB  . LYS A 1 473 ? 204.66600 373.59000 41.37000  1.000 137.90367 ? 508 LYS F CB  1 
ATOM   3429 C CG  . LYS A 1 473 ? 204.09200 373.63000 39.95900  1.000 136.53208 ? 508 LYS F CG  1 
ATOM   3430 C CD  . LYS A 1 473 ? 204.68100 372.56300 39.05200  1.000 136.81156 ? 508 LYS F CD  1 
ATOM   3431 C CE  . LYS A 1 473 ? 206.14300 372.82000 38.75400  1.000 137.24661 ? 508 LYS F CE  1 
ATOM   3432 N NZ  . LYS A 1 473 ? 206.67500 371.81100 37.79700  1.000 135.78784 ? 508 LYS F NZ  1 
ATOM   3433 N N   . SER A 1 474 ? 202.70600 376.21800 41.26500  1.000 141.08990 ? 509 SER F N   1 
ATOM   3434 C CA  . SER A 1 474 ? 202.55300 377.63500 40.91900  1.000 139.29705 ? 509 SER F CA  1 
ATOM   3435 C C   . SER A 1 474 ? 201.41300 378.27400 41.71600  1.000 136.72276 ? 509 SER F C   1 
ATOM   3436 O O   . SER A 1 474 ? 201.45700 378.34700 42.94500  1.000 134.57005 ? 509 SER F O   1 
ATOM   3437 C CB  . SER A 1 474 ? 202.31000 377.81700 39.42000  1.000 136.18671 ? 509 SER F CB  1 
ATOM   3438 O OG  . SER A 1 474 ? 201.12000 377.17200 39.00700  1.000 136.03530 ? 509 SER F OG  1 
HETATM 3439 C C1  . EDO B 2 .   ? 176.72900 353.02300 41.14400  1.000 49.75219  ? 701 EDO F C1  1 
HETATM 3440 O O1  . EDO B 2 .   ? 178.02700 353.63000 41.15200  1.000 52.84636  ? 701 EDO F O1  1 
HETATM 3441 C C2  . EDO B 2 .   ? 176.43200 352.28700 39.82300  1.000 54.62275  ? 701 EDO F C2  1 
HETATM 3442 O O2  . EDO B 2 .   ? 176.97300 352.94300 38.63900  1.000 46.39348  ? 701 EDO F O2  1 
HETATM 3443 H H11 . EDO B 2 .   ? 175.97200 353.79500 41.30100  1.000 59.67690  ? 701 EDO F H11 1 
HETATM 3444 H H12 . EDO B 2 .   ? 176.66100 352.31300 41.97200  1.000 59.67690  ? 701 EDO F H12 1 
HETATM 3445 H HO1 . EDO B 2 .   ? 178.14200 354.13400 41.97000  1.000 63.38989  ? 701 EDO F HO1 1 
HETATM 3446 H H21 . EDO B 2 .   ? 175.35000 352.19800 39.70900  1.000 65.52157  ? 701 EDO F H21 1 
HETATM 3447 H H22 . EDO B 2 .   ? 176.84700 351.27900 39.88500  1.000 65.52157  ? 701 EDO F H22 1 
HETATM 3448 H HO2 . EDO B 2 .   ? 176.74100 352.43000 37.85200  1.000 55.64644  ? 701 EDO F HO2 1 
HETATM 3449 C C1  . NAG C 3 .   ? 195.33800 360.69100 43.85800  1.000 114.74386 ? 702 NAG F C1  1 
HETATM 3450 C C2  . NAG C 3 .   ? 195.93400 359.29900 44.11100  1.000 119.37751 ? 702 NAG F C2  1 
HETATM 3451 C C3  . NAG C 3 .   ? 195.06000 358.53400 45.09700  1.000 121.42329 ? 702 NAG F C3  1 
HETATM 3452 C C4  . NAG C 3 .   ? 194.98200 359.32000 46.40100  1.000 122.89042 ? 702 NAG F C4  1 
HETATM 3453 C C5  . NAG C 3 .   ? 194.43300 360.72700 46.14100  1.000 121.39605 ? 702 NAG F C5  1 
HETATM 3454 C C6  . NAG C 3 .   ? 194.47800 361.60900 47.37000  1.000 121.60619 ? 702 NAG F C6  1 
HETATM 3455 C C7  . NAG C 3 .   ? 195.22100 358.01000 42.10500  1.000 103.58565 ? 702 NAG F C7  1 
HETATM 3456 C C8  . NAG C 3 .   ? 195.70700 357.23100 40.91600  1.000 94.84435  ? 702 NAG F C8  1 
HETATM 3457 N N2  . NAG C 3 .   ? 196.17300 358.52900 42.89300  1.000 113.48272 ? 702 NAG F N2  1 
HETATM 3458 O O3  . NAG C 3 .   ? 195.58900 357.23100 45.32400  1.000 124.47351 ? 702 NAG F O3  1 
HETATM 3459 O O4  . NAG C 3 .   ? 194.17800 358.64400 47.36300  1.000 123.11987 ? 702 NAG F O4  1 
HETATM 3460 O O5  . NAG C 3 .   ? 195.20200 361.40100 45.12600  1.000 118.52669 ? 702 NAG F O5  1 
HETATM 3461 O O6  . NAG C 3 .   ? 195.67500 361.41200 48.11300  1.000 121.73860 ? 702 NAG F O6  1 
HETATM 3462 O O7  . NAG C 3 .   ? 194.02900 358.16800 42.33200  1.000 103.35910 ? 702 NAG F O7  1 
HETATM 3463 O O   . HOH D 4 .   ? 173.19900 362.35500 24.70700  1.000 52.12250  ? 801 HOH F O   1 
HETATM 3464 O O   . HOH D 4 .   ? 183.64500 334.87000 27.57000  1.000 38.87453  ? 802 HOH F O   1 
HETATM 3465 O O   . HOH D 4 .   ? 188.44300 336.15400 2.10300   1.000 66.84698  ? 803 HOH F O   1 
HETATM 3466 O O   . HOH D 4 .   ? 179.36800 332.91600 -7.88300  1.000 61.81035  ? 804 HOH F O   1 
HETATM 3467 O O   . HOH D 4 .   ? 189.73000 323.24000 10.46100  1.000 58.78768  ? 805 HOH F O   1 
HETATM 3468 O O   . HOH D 4 .   ? 181.33800 347.03100 32.51100  1.000 42.84591  ? 806 HOH F O   1 
HETATM 3469 O O   . HOH D 4 .   ? 166.08400 371.23100 27.95000  1.000 40.88764  ? 807 HOH F O   1 
HETATM 3470 O O   . HOH D 4 .   ? 156.52500 362.35400 25.29500  1.000 41.91883  ? 808 HOH F O   1 
HETATM 3471 O O   . HOH D 4 .   ? 175.84700 342.99700 23.57600  1.000 51.26460  ? 809 HOH F O   1 
HETATM 3472 O O   . HOH D 4 .   ? 156.43600 360.99900 23.18600  1.000 48.97312  ? 810 HOH F O   1 
HETATM 3473 O O   . HOH D 4 .   ? 168.16400 369.80600 20.99100  1.000 43.58080  ? 811 HOH F O   1 
HETATM 3474 O O   . HOH D 4 .   ? 155.48500 351.83000 23.54600  1.000 49.66261  ? 812 HOH F O   1 
HETATM 3475 O O   . HOH D 4 .   ? 161.06300 365.22900 35.40700  1.000 43.10485  ? 813 HOH F O   1 
HETATM 3476 O O   . HOH D 4 .   ? 168.68800 335.75800 35.41200  1.000 50.61495  ? 814 HOH F O   1 
HETATM 3477 O O   . HOH D 4 .   ? 180.68700 361.39900 27.84800  1.000 42.36070  ? 815 HOH F O   1 
HETATM 3478 O O   . HOH D 4 .   ? 188.72300 338.24500 40.02900  1.000 38.66445  ? 816 HOH F O   1 
HETATM 3479 O O   . HOH D 4 .   ? 157.61400 352.21600 37.88600  1.000 59.30906  ? 817 HOH F O   1 
HETATM 3480 O O   . HOH D 4 .   ? 161.55500 326.77900 17.20900  1.000 56.26873  ? 818 HOH F O   1 
HETATM 3481 O O   . HOH D 4 .   ? 191.713   352.245   29.550    1.000 53.66678  ? 819 HOH F O   1 
HETATM 3482 O O   . HOH D 4 .   ? 175.93100 333.21700 38.67800  1.000 52.93396  ? 820 HOH F O   1 
HETATM 3483 O O   . HOH D 4 .   ? 191.05400 362.55800 22.88200  1.000 49.27729  ? 821 HOH F O   1 
HETATM 3484 O O   . HOH D 4 .   ? 186.29700 351.74100 39.99400  1.000 44.31598  ? 822 HOH F O   1 
HETATM 3485 O O   . HOH D 4 .   ? 165.08600 339.82100 37.80200  1.000 52.50430  ? 823 HOH F O   1 
HETATM 3486 O O   . HOH D 4 .   ? 180.16300 348.21100 24.48700  1.000 52.80994  ? 824 HOH F O   1 
HETATM 3487 O O   . HOH D 4 .   ? 181.46600 369.32100 38.14900  1.000 52.10110  ? 825 HOH F O   1 
HETATM 3488 O O   . HOH D 4 .   ? 161.07600 369.09600 34.00200  1.000 45.55766  ? 826 HOH F O   1 
HETATM 3489 O O   . HOH D 4 .   ? 171.30600 349.95700 25.34600  1.000 50.24056  ? 827 HOH F O   1 
HETATM 3490 O O   . HOH D 4 .   ? 179.12800 352.30800 26.98700  1.000 44.39486  ? 828 HOH F O   1 
HETATM 3491 O O   . HOH D 4 .   ? 168.08300 363.21500 37.21500  1.000 51.10926  ? 829 HOH F O   1 
HETATM 3492 O O   . HOH D 4 .   ? 163.05900 369.02100 28.26500  1.000 40.74837  ? 830 HOH F O   1 
HETATM 3493 O O   . HOH D 4 .   ? 180.17700 331.89400 37.01200  1.000 48.24935  ? 831 HOH F O   1 
HETATM 3494 O O   . HOH D 4 .   ? 184.26200 346.98400 31.95500  1.000 42.42958  ? 832 HOH F O   1 
HETATM 3495 O O   . HOH D 4 .   ? 169.64900 343.11200 22.94100  1.000 51.59314  ? 833 HOH F O   1 
HETATM 3496 O O   . HOH D 4 .   ? 159.70100 357.51000 15.67800  1.000 45.37306  ? 834 HOH F O   1 
HETATM 3497 O O   . HOH D 4 .   ? 175.19600 325.94700 32.17200  1.000 45.98429  ? 835 HOH F O   1 
HETATM 3498 O O   . HOH D 4 .   ? 161.51100 350.13700 27.03200  1.000 47.25997  ? 836 HOH F O   1 
HETATM 3499 O O   . HOH D 4 .   ? 156.405   369.931   28.954    1.000 39.35246  ? 837 HOH F O   1 
HETATM 3500 O O   . HOH D 4 .   ? 169.027   364.732   20.168    1.000 41.94005  ? 838 HOH F O   1 
HETATM 3501 O O   . HOH D 4 .   ? 174.90800 370.46800 29.62400  1.000 49.45753  ? 839 HOH F O   1 
HETATM 3502 O O   . HOH D 4 .   ? 167.19200 353.11300 22.34400  1.000 49.13317  ? 840 HOH F O   1 
HETATM 3503 O O   . HOH D 4 .   ? 172.37500 356.03600 41.60100  1.000 47.38094  ? 841 HOH F O   1 
HETATM 3504 O O   . HOH D 4 .   ? 171.61000 361.69900 36.48600  1.000 39.15124  ? 842 HOH F O   1 
HETATM 3505 O O   . HOH D 4 .   ? 191.13200 364.59200 28.22300  1.000 52.55495  ? 843 HOH F O   1 
HETATM 3506 O O   . HOH D 4 .   ? 169.37900 377.69400 27.36100  1.000 53.92836  ? 844 HOH F O   1 
HETATM 3507 O O   . HOH D 4 .   ? 159.30500 355.59400 36.31700  1.000 55.42872  ? 845 HOH F O   1 
HETATM 3508 O O   . HOH D 4 .   ? 176.82800 356.61800 31.68900  1.000 36.94627  ? 846 HOH F O   1 
HETATM 3509 O O   . HOH D 4 .   ? 189.93100 342.91200 42.74800  1.000 55.22182  ? 847 HOH F O   1 
HETATM 3510 O O   . HOH D 4 .   ? 172.20500 371.54200 29.72700  1.000 43.54002  ? 848 HOH F O   1 
HETATM 3511 O O   . HOH D 4 .   ? 187.25500 335.46600 25.94200  1.000 46.21839  ? 849 HOH F O   1 
HETATM 3512 O O   . HOH D 4 .   ? 166.80200 364.27600 31.83100  1.000 43.38394  ? 850 HOH F O   1 
HETATM 3513 O O   . HOH D 4 .   ? 180.80000 349.59500 32.64500  1.000 37.05665  ? 851 HOH F O   1 
HETATM 3514 O O   . HOH D 4 .   ? 182.40000 329.54800 27.64600  1.000 39.19930  ? 852 HOH F O   1 
HETATM 3515 O O   . HOH D 4 .   ? 173.02300 322.70900 22.01800  1.000 55.77669  ? 853 HOH F O   1 
HETATM 3516 O O   . HOH D 4 .   ? 148.00300 353.59700 26.09800  1.000 60.50372  ? 854 HOH F O   1 
HETATM 3517 O O   . HOH D 4 .   ? 160.41900 366.36400 22.16100  1.000 46.60886  ? 855 HOH F O   1 
HETATM 3518 O O   . HOH D 4 .   ? 180.39900 341.01500 20.66400  1.000 48.03331  ? 856 HOH F O   1 
HETATM 3519 O O   . HOH D 4 .   ? 152.43600 358.24300 23.62400  1.000 51.92488  ? 857 HOH F O   1 
HETATM 3520 O O   . HOH D 4 .   ? 179.36100 362.69200 25.44700  1.000 58.77277  ? 858 HOH F O   1 
HETATM 3521 O O   . HOH D 4 .   ? 188.99500 334.87000 34.08900  1.000 46.00814  ? 859 HOH F O   1 
HETATM 3522 O O   . HOH D 4 .   ? 171.99600 364.21100 35.89200  1.000 38.08563  ? 860 HOH F O   1 
HETATM 3523 O O   . HOH D 4 .   ? 179.68000 346.58700 34.82600  1.000 41.32402  ? 861 HOH F O   1 
HETATM 3524 O O   . HOH D 4 .   ? 150.85100 366.84000 26.16900  1.000 52.10836  ? 862 HOH F O   1 
HETATM 3525 O O   . HOH D 4 .   ? 178.55700 358.99500 25.36400  1.000 51.81838  ? 863 HOH F O   1 
HETATM 3526 O O   . HOH D 4 .   ? 185.88000 336.20800 38.40500  1.000 37.51261  ? 864 HOH F O   1 
HETATM 3527 O O   . HOH D 4 .   ? 175.97500 323.88500 30.99700  1.000 44.21359  ? 865 HOH F O   1 
HETATM 3528 O O   . HOH D 4 .   ? 162.58300 361.07400 37.75900  1.000 49.73371  ? 866 HOH F O   1 
HETATM 3529 O O   . HOH D 4 .   ? 175.16200 337.88300 38.50500  1.000 59.15303  ? 867 HOH F O   1 
HETATM 3530 O O   . HOH D 4 .   ? 183.82300 349.19900 33.30000  1.000 45.81758  ? 868 HOH F O   1 
HETATM 3531 O O   . HOH D 4 .   ? 188.47500 367.30900 40.61100  1.000 57.65207  ? 869 HOH F O   1 
HETATM 3532 O O   . HOH D 4 .   ? 184.58100 326.10800 14.06600  1.000 56.97144  ? 870 HOH F O   1 
HETATM 3533 O O   . HOH D 4 .   ? 176.03500 357.49800 24.36200  1.000 52.41088  ? 871 HOH F O   1 
HETATM 3534 O O   . HOH D 4 .   ? 173.20700 351.92300 26.03000  1.000 39.00727  ? 872 HOH F O   1 
HETATM 3535 O O   . HOH D 4 .   ? 173.17500 348.17500 25.58400  1.000 43.68107  ? 873 HOH F O   1 
HETATM 3536 O O   . HOH D 4 .   ? 183.915   326.100   19.648    1.000 56.08316  ? 874 HOH F O   1 
HETATM 3537 O O   . HOH D 4 .   ? 163.84100 371.64600 37.22400  1.000 50.73462  ? 875 HOH F O   1 
HETATM 3538 O O   . HOH D 4 .   ? 177.83100 345.09700 33.77500  1.000 40.98154  ? 876 HOH F O   1 
HETATM 3539 O O   . HOH D 4 .   ? 182.56500 351.03300 25.20300  1.000 55.44740  ? 877 HOH F O   1 
HETATM 3540 O O   . HOH D 4 .   ? 162.39800 323.10200 -3.59300  1.000 60.55449  ? 878 HOH F O   1 
HETATM 3541 O O   . HOH D 4 .   ? 189.32900 333.86000 12.37100  1.000 68.89804  ? 879 HOH F O   1 
HETATM 3542 O O   . HOH D 4 .   ? 178.671   328.857   35.108    1.000 41.38169  ? 880 HOH F O   1 
HETATM 3543 O O   . HOH D 4 .   ? 188.91400 342.89000 38.99200  1.000 44.77433  ? 881 HOH F O   1 
HETATM 3544 O O   . HOH D 4 .   ? 164.16300 370.34700 21.15700  1.000 34.41050  ? 882 HOH F O   1 
HETATM 3545 O O   . HOH D 4 .   ? 159.65000 321.68900 6.88200   1.000 68.72235  ? 883 HOH F O   1 
HETATM 3546 O O   . HOH D 4 .   ? 189.22700 337.01800 35.21500  1.000 48.35696  ? 884 HOH F O   1 
HETATM 3547 O O   . HOH D 4 .   ? 180.26300 351.83700 24.90700  1.000 55.28662  ? 885 HOH F O   1 
HETATM 3548 O O   . HOH D 4 .   ? 190.17100 340.40700 39.41400  1.000 51.51100  ? 886 HOH F O   1 
HETATM 3549 O O   . HOH D 4 .   ? 177.98200 330.86800 36.14500  1.000 43.32256  ? 887 HOH F O   1 
HETATM 3550 O O   . HOH D 4 .   ? 169.37900 332.70500 4.50400   1.000 61.47128  ? 888 HOH F O   1 
HETATM 3551 O O   . HOH D 4 .   ? 174.38000 347.70800 23.57700  1.000 50.64723  ? 889 HOH F O   1 
HETATM 3552 O O   . HOH D 4 .   ? 151.61900 356.43700 21.92100  1.000 54.61554  ? 890 HOH F O   1 
HETATM 3553 O O   . HOH D 4 .   ? 164.800   378.644   22.532    1.000 37.41029  ? 891 HOH F O   1 
# 
