data_8W3F
# 
_entry.id   8W3F 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W3F         pdb_00008w3f 10.2210/pdb8w3f/pdb 
WWPDB D_1000280342 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W3F 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jiang@scripps.edu 
_pdbx_contact_author.name_first         JIANG 
_pdbx_contact_author.name_last          ZHU 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0259-7157 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lee, Y.Z.'       1 ? 
'Stanfield, R.L.' 2 ? 
'Wilson, I.A.'    3 ? 
'Zhu, J.'         4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9939 
_citation.page_last                 9939 
_citation.title                     
'Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54287-x 
_citation.pdbx_database_id_PubMed   39550381 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lee, Y.Z.'       1  0000-0002-5651-863X 
primary 'Han, J.'         2  ?                   
primary 'Zhang, Y.N.'     3  0000-0001-9053-5890 
primary 'Ward, G.'        4  ?                   
primary 'Braz Gomes, K.'  5  ?                   
primary 'Auclair, S.'     6  ?                   
primary 'Stanfield, R.L.' 7  ?                   
primary 'He, L.'          8  ?                   
primary 'Wilson, I.A.'    9  0000-0002-6469-2419 
primary 'Zhu, J.'         10 0000-0003-0259-7157 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Prefusion-stabilized RSV F protein UFCR1-P2-NQ' 55708.703 1  ? ? ? ? 
2 non-polymer syn 1,2-ETHANEDIOL                                   62.068    1  ? ? ? ? 
3 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose         221.208   1  ? ? ? ? 
4 water       nat water                                            18.015    61 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGPSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSNQFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGPSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSNQFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_strand_id                 F 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1,2-ETHANEDIOL                           EDO 
3 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
4 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   ILE n 
1 4   LEU n 
1 5   PRO n 
1 6   SER n 
1 7   PRO n 
1 8   GLY n 
1 9   MET n 
1 10  PRO n 
1 11  ALA n 
1 12  LEU n 
1 13  LEU n 
1 14  SER n 
1 15  LEU n 
1 16  VAL n 
1 17  SER n 
1 18  LEU n 
1 19  LEU n 
1 20  SER n 
1 21  VAL n 
1 22  LEU n 
1 23  LEU n 
1 24  MET n 
1 25  GLY n 
1 26  CYS n 
1 27  VAL n 
1 28  ALA n 
1 29  GLU n 
1 30  GLN n 
1 31  ASN n 
1 32  ILE n 
1 33  THR n 
1 34  GLU n 
1 35  GLU n 
1 36  PHE n 
1 37  TYR n 
1 38  GLN n 
1 39  SER n 
1 40  THR n 
1 41  CYS n 
1 42  SER n 
1 43  ALA n 
1 44  VAL n 
1 45  SER n 
1 46  LYS n 
1 47  GLY n 
1 48  TYR n 
1 49  LEU n 
1 50  SER n 
1 51  ALA n 
1 52  LEU n 
1 53  ARG n 
1 54  THR n 
1 55  GLY n 
1 56  TRP n 
1 57  TYR n 
1 58  THR n 
1 59  SER n 
1 60  VAL n 
1 61  ILE n 
1 62  THR n 
1 63  ILE n 
1 64  GLU n 
1 65  LEU n 
1 66  SER n 
1 67  ASN n 
1 68  ILE n 
1 69  LYS n 
1 70  GLU n 
1 71  ASN n 
1 72  LYS n 
1 73  CYS n 
1 74  ASN n 
1 75  GLY n 
1 76  THR n 
1 77  ASP n 
1 78  ALA n 
1 79  LYS n 
1 80  VAL n 
1 81  LYS n 
1 82  LEU n 
1 83  ILE n 
1 84  LYS n 
1 85  GLN n 
1 86  GLU n 
1 87  LEU n 
1 88  ASP n 
1 89  LYS n 
1 90  TYR n 
1 91  LYS n 
1 92  ASN n 
1 93  ALA n 
1 94  VAL n 
1 95  THR n 
1 96  ASP n 
1 97  LEU n 
1 98  GLN n 
1 99  LEU n 
1 100 LEU n 
1 101 MET n 
1 102 GLN n 
1 103 SER n 
1 104 THR n 
1 105 PRO n 
1 106 ALA n 
1 107 THR n 
1 108 GLY n 
1 109 SER n 
1 110 GLY n 
1 111 SER n 
1 112 ALA n 
1 113 ILE n 
1 114 ALA n 
1 115 SER n 
1 116 GLY n 
1 117 VAL n 
1 118 ALA n 
1 119 VAL n 
1 120 CYS n 
1 121 LYS n 
1 122 VAL n 
1 123 LEU n 
1 124 HIS n 
1 125 LEU n 
1 126 GLU n 
1 127 GLY n 
1 128 GLU n 
1 129 VAL n 
1 130 ASN n 
1 131 LYS n 
1 132 ILE n 
1 133 LYS n 
1 134 SER n 
1 135 ALA n 
1 136 LEU n 
1 137 LEU n 
1 138 SER n 
1 139 THR n 
1 140 ASN n 
1 141 LYS n 
1 142 ALA n 
1 143 VAL n 
1 144 VAL n 
1 145 SER n 
1 146 LEU n 
1 147 SER n 
1 148 ASN n 
1 149 GLY n 
1 150 PRO n 
1 151 SER n 
1 152 VAL n 
1 153 LEU n 
1 154 THR n 
1 155 SER n 
1 156 LYS n 
1 157 VAL n 
1 158 LEU n 
1 159 ASP n 
1 160 LEU n 
1 161 LYS n 
1 162 ASN n 
1 163 TYR n 
1 164 ILE n 
1 165 ASP n 
1 166 LYS n 
1 167 GLN n 
1 168 LEU n 
1 169 LEU n 
1 170 PRO n 
1 171 ILE n 
1 172 VAL n 
1 173 ASN n 
1 174 LYS n 
1 175 GLN n 
1 176 SER n 
1 177 CYS n 
1 178 SER n 
1 179 ILE n 
1 180 PRO n 
1 181 ASN n 
1 182 ILE n 
1 183 GLU n 
1 184 THR n 
1 185 VAL n 
1 186 ILE n 
1 187 GLU n 
1 188 PHE n 
1 189 GLN n 
1 190 GLN n 
1 191 LYS n 
1 192 ASN n 
1 193 ASN n 
1 194 ARG n 
1 195 LEU n 
1 196 LEU n 
1 197 GLU n 
1 198 ILE n 
1 199 THR n 
1 200 ARG n 
1 201 GLU n 
1 202 PHE n 
1 203 SER n 
1 204 VAL n 
1 205 ASN n 
1 206 ALA n 
1 207 GLY n 
1 208 VAL n 
1 209 THR n 
1 210 THR n 
1 211 PRO n 
1 212 VAL n 
1 213 SER n 
1 214 THR n 
1 215 TYR n 
1 216 MET n 
1 217 LEU n 
1 218 THR n 
1 219 ASN n 
1 220 SER n 
1 221 GLU n 
1 222 LEU n 
1 223 LEU n 
1 224 SER n 
1 225 LEU n 
1 226 ILE n 
1 227 ASN n 
1 228 ASP n 
1 229 MET n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 ASN n 
1 234 ASP n 
1 235 GLN n 
1 236 LYS n 
1 237 LYS n 
1 238 LEU n 
1 239 MET n 
1 240 SER n 
1 241 ASN n 
1 242 ASN n 
1 243 VAL n 
1 244 GLN n 
1 245 ILE n 
1 246 VAL n 
1 247 ARG n 
1 248 GLN n 
1 249 GLN n 
1 250 SER n 
1 251 TYR n 
1 252 SER n 
1 253 ILE n 
1 254 MET n 
1 255 CYS n 
1 256 ILE n 
1 257 ILE n 
1 258 LYS n 
1 259 GLU n 
1 260 GLU n 
1 261 VAL n 
1 262 LEU n 
1 263 ALA n 
1 264 TYR n 
1 265 VAL n 
1 266 VAL n 
1 267 GLN n 
1 268 LEU n 
1 269 PRO n 
1 270 LEU n 
1 271 TYR n 
1 272 GLY n 
1 273 VAL n 
1 274 ILE n 
1 275 ASP n 
1 276 THR n 
1 277 PRO n 
1 278 CYS n 
1 279 TRP n 
1 280 LYS n 
1 281 LEU n 
1 282 HIS n 
1 283 THR n 
1 284 SER n 
1 285 PRO n 
1 286 LEU n 
1 287 CYS n 
1 288 THR n 
1 289 THR n 
1 290 ASN n 
1 291 THR n 
1 292 LYS n 
1 293 GLU n 
1 294 GLY n 
1 295 SER n 
1 296 ASN n 
1 297 ILE n 
1 298 CYS n 
1 299 LEU n 
1 300 THR n 
1 301 ARG n 
1 302 THR n 
1 303 ASP n 
1 304 ARG n 
1 305 GLY n 
1 306 TRP n 
1 307 TYR n 
1 308 CYS n 
1 309 ASP n 
1 310 ASN n 
1 311 ALA n 
1 312 GLY n 
1 313 SER n 
1 314 VAL n 
1 315 SER n 
1 316 PHE n 
1 317 PHE n 
1 318 PRO n 
1 319 GLN n 
1 320 ALA n 
1 321 GLU n 
1 322 THR n 
1 323 CYS n 
1 324 LYS n 
1 325 VAL n 
1 326 GLN n 
1 327 SER n 
1 328 ASN n 
1 329 ARG n 
1 330 VAL n 
1 331 PHE n 
1 332 CYS n 
1 333 ASP n 
1 334 THR n 
1 335 MET n 
1 336 ASN n 
1 337 SER n 
1 338 LEU n 
1 339 THR n 
1 340 LEU n 
1 341 PRO n 
1 342 SER n 
1 343 GLU n 
1 344 VAL n 
1 345 ASN n 
1 346 LEU n 
1 347 CYS n 
1 348 ASN n 
1 349 VAL n 
1 350 ASP n 
1 351 ILE n 
1 352 PHE n 
1 353 ASN n 
1 354 PRO n 
1 355 LYS n 
1 356 TYR n 
1 357 ASP n 
1 358 CYS n 
1 359 LYS n 
1 360 ILE n 
1 361 MET n 
1 362 THR n 
1 363 SER n 
1 364 LYS n 
1 365 THR n 
1 366 ASP n 
1 367 VAL n 
1 368 SER n 
1 369 SER n 
1 370 SER n 
1 371 VAL n 
1 372 ILE n 
1 373 THR n 
1 374 SER n 
1 375 LEU n 
1 376 GLY n 
1 377 ALA n 
1 378 ILE n 
1 379 VAL n 
1 380 SER n 
1 381 CYS n 
1 382 TYR n 
1 383 GLY n 
1 384 LYS n 
1 385 THR n 
1 386 LYS n 
1 387 CYS n 
1 388 THR n 
1 389 ALA n 
1 390 SER n 
1 391 ASN n 
1 392 LYS n 
1 393 ASN n 
1 394 ARG n 
1 395 GLY n 
1 396 ILE n 
1 397 ILE n 
1 398 LYS n 
1 399 THR n 
1 400 PHE n 
1 401 SER n 
1 402 ASN n 
1 403 GLY n 
1 404 CYS n 
1 405 ASP n 
1 406 TYR n 
1 407 VAL n 
1 408 SER n 
1 409 ASN n 
1 410 LYS n 
1 411 GLY n 
1 412 VAL n 
1 413 ASP n 
1 414 THR n 
1 415 VAL n 
1 416 SER n 
1 417 VAL n 
1 418 GLY n 
1 419 ASN n 
1 420 THR n 
1 421 LEU n 
1 422 TYR n 
1 423 TYR n 
1 424 VAL n 
1 425 ASN n 
1 426 LYS n 
1 427 GLN n 
1 428 GLU n 
1 429 GLY n 
1 430 LYS n 
1 431 SER n 
1 432 LEU n 
1 433 TYR n 
1 434 VAL n 
1 435 LYS n 
1 436 GLY n 
1 437 GLU n 
1 438 PRO n 
1 439 ILE n 
1 440 ILE n 
1 441 ASN n 
1 442 PHE n 
1 443 TYR n 
1 444 ASP n 
1 445 PRO n 
1 446 LEU n 
1 447 VAL n 
1 448 PHE n 
1 449 PRO n 
1 450 SER n 
1 451 ASN n 
1 452 GLN n 
1 453 PHE n 
1 454 ASP n 
1 455 ALA n 
1 456 SER n 
1 457 ILE n 
1 458 SER n 
1 459 GLN n 
1 460 VAL n 
1 461 ASN n 
1 462 GLU n 
1 463 LYS n 
1 464 ILE n 
1 465 ASN n 
1 466 GLN n 
1 467 SER n 
1 468 LEU n 
1 469 ALA n 
1 470 PHE n 
1 471 ILE n 
1 472 ARG n 
1 473 LYS n 
1 474 SER n 
1 475 ASP n 
1 476 GLU n 
1 477 LEU n 
1 478 LEU n 
1 479 ALA n 
1 480 SER n 
1 481 GLY n 
1 482 TYR n 
1 483 ILE n 
1 484 PRO n 
1 485 GLU n 
1 486 ALA n 
1 487 PRO n 
1 488 ARG n 
1 489 ASP n 
1 490 GLY n 
1 491 GLN n 
1 492 ALA n 
1 493 TYR n 
1 494 VAL n 
1 495 ARG n 
1 496 LYS n 
1 497 ASP n 
1 498 GLY n 
1 499 GLU n 
1 500 TRP n 
1 501 VAL n 
1 502 LEU n 
1 503 LEU n 
1 504 SER n 
1 505 THR n 
1 506 PHE n 
1 507 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   507 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Human respiratory syncytial virus A2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11259 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
EDO non-polymer                  . 1,2-ETHANEDIOL                           'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -3  ?   ?   ?   F . n 
A 1 2   GLY 2   -2  ?   ?   ?   F . n 
A 1 3   ILE 3   -1  ?   ?   ?   F . n 
A 1 4   LEU 4   0   ?   ?   ?   F . n 
A 1 5   PRO 5   1   ?   ?   ?   F . n 
A 1 6   SER 6   2   ?   ?   ?   F . n 
A 1 7   PRO 7   3   ?   ?   ?   F . n 
A 1 8   GLY 8   4   ?   ?   ?   F . n 
A 1 9   MET 9   5   ?   ?   ?   F . n 
A 1 10  PRO 10  6   ?   ?   ?   F . n 
A 1 11  ALA 11  7   ?   ?   ?   F . n 
A 1 12  LEU 12  8   ?   ?   ?   F . n 
A 1 13  LEU 13  9   ?   ?   ?   F . n 
A 1 14  SER 14  10  ?   ?   ?   F . n 
A 1 15  LEU 15  11  ?   ?   ?   F . n 
A 1 16  VAL 16  12  ?   ?   ?   F . n 
A 1 17  SER 17  13  ?   ?   ?   F . n 
A 1 18  LEU 18  14  ?   ?   ?   F . n 
A 1 19  LEU 19  15  ?   ?   ?   F . n 
A 1 20  SER 20  16  ?   ?   ?   F . n 
A 1 21  VAL 21  17  ?   ?   ?   F . n 
A 1 22  LEU 22  18  ?   ?   ?   F . n 
A 1 23  LEU 23  19  ?   ?   ?   F . n 
A 1 24  MET 24  20  ?   ?   ?   F . n 
A 1 25  GLY 25  21  ?   ?   ?   F . n 
A 1 26  CYS 26  22  ?   ?   ?   F . n 
A 1 27  VAL 27  23  ?   ?   ?   F . n 
A 1 28  ALA 28  24  ?   ?   ?   F . n 
A 1 29  GLU 29  25  ?   ?   ?   F . n 
A 1 30  GLN 30  26  26  GLN GLN F . n 
A 1 31  ASN 31  27  27  ASN ASN F . n 
A 1 32  ILE 32  28  28  ILE ILE F . n 
A 1 33  THR 33  29  29  THR THR F . n 
A 1 34  GLU 34  30  30  GLU GLU F . n 
A 1 35  GLU 35  31  31  GLU GLU F . n 
A 1 36  PHE 36  32  32  PHE PHE F . n 
A 1 37  TYR 37  33  33  TYR TYR F . n 
A 1 38  GLN 38  34  34  GLN GLN F . n 
A 1 39  SER 39  35  35  SER SER F . n 
A 1 40  THR 40  36  36  THR THR F . n 
A 1 41  CYS 41  37  37  CYS CYS F . n 
A 1 42  SER 42  38  38  SER SER F . n 
A 1 43  ALA 43  39  39  ALA ALA F . n 
A 1 44  VAL 44  40  40  VAL VAL F . n 
A 1 45  SER 45  41  41  SER SER F . n 
A 1 46  LYS 46  42  42  LYS LYS F . n 
A 1 47  GLY 47  43  43  GLY GLY F . n 
A 1 48  TYR 48  44  44  TYR TYR F . n 
A 1 49  LEU 49  45  45  LEU LEU F . n 
A 1 50  SER 50  46  46  SER SER F . n 
A 1 51  ALA 51  47  47  ALA ALA F . n 
A 1 52  LEU 52  48  48  LEU LEU F . n 
A 1 53  ARG 53  49  49  ARG ARG F . n 
A 1 54  THR 54  50  50  THR THR F . n 
A 1 55  GLY 55  51  51  GLY GLY F . n 
A 1 56  TRP 56  52  52  TRP TRP F . n 
A 1 57  TYR 57  53  53  TYR TYR F . n 
A 1 58  THR 58  54  54  THR THR F . n 
A 1 59  SER 59  55  55  SER SER F . n 
A 1 60  VAL 60  56  56  VAL VAL F . n 
A 1 61  ILE 61  57  57  ILE ILE F . n 
A 1 62  THR 62  58  58  THR THR F . n 
A 1 63  ILE 63  59  59  ILE ILE F . n 
A 1 64  GLU 64  60  60  GLU GLU F . n 
A 1 65  LEU 65  61  61  LEU LEU F . n 
A 1 66  SER 66  62  62  SER SER F . n 
A 1 67  ASN 67  63  63  ASN ASN F . n 
A 1 68  ILE 68  64  64  ILE ILE F . n 
A 1 69  LYS 69  65  65  LYS LYS F . n 
A 1 70  GLU 70  66  66  GLU GLU F . n 
A 1 71  ASN 71  67  67  ASN ASN F . n 
A 1 72  LYS 72  68  68  LYS LYS F . n 
A 1 73  CYS 73  69  69  CYS CYS F . n 
A 1 74  ASN 74  70  70  ASN ASN F . n 
A 1 75  GLY 75  71  71  GLY GLY F . n 
A 1 76  THR 76  72  72  THR THR F . n 
A 1 77  ASP 77  73  73  ASP ASP F . n 
A 1 78  ALA 78  74  74  ALA ALA F . n 
A 1 79  LYS 79  75  75  LYS LYS F . n 
A 1 80  VAL 80  76  76  VAL VAL F . n 
A 1 81  LYS 81  77  77  LYS LYS F . n 
A 1 82  LEU 82  78  78  LEU LEU F . n 
A 1 83  ILE 83  79  79  ILE ILE F . n 
A 1 84  LYS 84  80  80  LYS LYS F . n 
A 1 85  GLN 85  81  81  GLN GLN F . n 
A 1 86  GLU 86  82  82  GLU GLU F . n 
A 1 87  LEU 87  83  83  LEU LEU F . n 
A 1 88  ASP 88  84  84  ASP ASP F . n 
A 1 89  LYS 89  85  85  LYS LYS F . n 
A 1 90  TYR 90  86  86  TYR TYR F . n 
A 1 91  LYS 91  87  87  LYS LYS F . n 
A 1 92  ASN 92  88  88  ASN ASN F . n 
A 1 93  ALA 93  89  89  ALA ALA F . n 
A 1 94  VAL 94  90  90  VAL VAL F . n 
A 1 95  THR 95  91  91  THR THR F . n 
A 1 96  ASP 96  92  92  ASP ASP F . n 
A 1 97  LEU 97  93  93  LEU LEU F . n 
A 1 98  GLN 98  94  94  GLN GLN F . n 
A 1 99  LEU 99  95  95  LEU LEU F . n 
A 1 100 LEU 100 96  96  LEU LEU F . n 
A 1 101 MET 101 97  97  MET MET F . n 
A 1 102 GLN 102 98  98  GLN GLN F . n 
A 1 103 SER 103 99  99  SER SER F . n 
A 1 104 THR 104 100 100 THR THR F . n 
A 1 105 PRO 105 101 101 PRO PRO F . n 
A 1 106 ALA 106 102 102 ALA ALA F . n 
A 1 107 THR 107 103 103 THR THR F . n 
A 1 108 GLY 108 143 143 GLY GLY F . n 
A 1 109 SER 109 144 144 SER SER F . n 
A 1 110 GLY 110 145 145 GLY GLY F . n 
A 1 111 SER 111 146 146 SER SER F . n 
A 1 112 ALA 112 147 147 ALA ALA F . n 
A 1 113 ILE 113 148 148 ILE ILE F . n 
A 1 114 ALA 114 149 149 ALA ALA F . n 
A 1 115 SER 115 150 150 SER SER F . n 
A 1 116 GLY 116 151 151 GLY GLY F . n 
A 1 117 VAL 117 152 152 VAL VAL F . n 
A 1 118 ALA 118 153 153 ALA ALA F . n 
A 1 119 VAL 119 154 154 VAL VAL F . n 
A 1 120 CYS 120 155 155 CYS CYS F . n 
A 1 121 LYS 121 156 156 LYS LYS F . n 
A 1 122 VAL 122 157 157 VAL VAL F . n 
A 1 123 LEU 123 158 158 LEU LEU F . n 
A 1 124 HIS 124 159 159 HIS HIS F . n 
A 1 125 LEU 125 160 160 LEU LEU F . n 
A 1 126 GLU 126 161 161 GLU GLU F . n 
A 1 127 GLY 127 162 162 GLY GLY F . n 
A 1 128 GLU 128 163 163 GLU GLU F . n 
A 1 129 VAL 129 164 164 VAL VAL F . n 
A 1 130 ASN 130 165 165 ASN ASN F . n 
A 1 131 LYS 131 166 166 LYS LYS F . n 
A 1 132 ILE 132 167 167 ILE ILE F . n 
A 1 133 LYS 133 168 168 LYS LYS F . n 
A 1 134 SER 134 169 169 SER SER F . n 
A 1 135 ALA 135 170 170 ALA ALA F . n 
A 1 136 LEU 136 171 171 LEU LEU F . n 
A 1 137 LEU 137 172 172 LEU LEU F . n 
A 1 138 SER 138 173 173 SER SER F . n 
A 1 139 THR 139 174 174 THR THR F . n 
A 1 140 ASN 140 175 175 ASN ASN F . n 
A 1 141 LYS 141 176 176 LYS LYS F . n 
A 1 142 ALA 142 177 177 ALA ALA F . n 
A 1 143 VAL 143 178 178 VAL VAL F . n 
A 1 144 VAL 144 179 179 VAL VAL F . n 
A 1 145 SER 145 180 180 SER SER F . n 
A 1 146 LEU 146 181 181 LEU LEU F . n 
A 1 147 SER 147 182 182 SER SER F . n 
A 1 148 ASN 148 183 183 ASN ASN F . n 
A 1 149 GLY 149 184 184 GLY GLY F . n 
A 1 150 PRO 150 185 185 PRO PRO F . n 
A 1 151 SER 151 186 186 SER SER F . n 
A 1 152 VAL 152 187 187 VAL VAL F . n 
A 1 153 LEU 153 188 188 LEU LEU F . n 
A 1 154 THR 154 189 189 THR THR F . n 
A 1 155 SER 155 190 190 SER SER F . n 
A 1 156 LYS 156 191 191 LYS LYS F . n 
A 1 157 VAL 157 192 192 VAL VAL F . n 
A 1 158 LEU 158 193 193 LEU LEU F . n 
A 1 159 ASP 159 194 194 ASP ASP F . n 
A 1 160 LEU 160 195 195 LEU LEU F . n 
A 1 161 LYS 161 196 196 LYS LYS F . n 
A 1 162 ASN 162 197 197 ASN ASN F . n 
A 1 163 TYR 163 198 198 TYR TYR F . n 
A 1 164 ILE 164 199 199 ILE ILE F . n 
A 1 165 ASP 165 200 200 ASP ASP F . n 
A 1 166 LYS 166 201 201 LYS LYS F . n 
A 1 167 GLN 167 202 202 GLN GLN F . n 
A 1 168 LEU 168 203 203 LEU LEU F . n 
A 1 169 LEU 169 204 204 LEU LEU F . n 
A 1 170 PRO 170 205 205 PRO PRO F . n 
A 1 171 ILE 171 206 206 ILE ILE F . n 
A 1 172 VAL 172 207 207 VAL VAL F . n 
A 1 173 ASN 173 208 208 ASN ASN F . n 
A 1 174 LYS 174 209 209 LYS LYS F . n 
A 1 175 GLN 175 210 210 GLN GLN F . n 
A 1 176 SER 176 211 211 SER SER F . n 
A 1 177 CYS 177 212 212 CYS CYS F . n 
A 1 178 SER 178 213 213 SER SER F . n 
A 1 179 ILE 179 214 214 ILE ILE F . n 
A 1 180 PRO 180 215 215 PRO PRO F . n 
A 1 181 ASN 181 216 216 ASN ASN F . n 
A 1 182 ILE 182 217 217 ILE ILE F . n 
A 1 183 GLU 183 218 218 GLU GLU F . n 
A 1 184 THR 184 219 219 THR THR F . n 
A 1 185 VAL 185 220 220 VAL VAL F . n 
A 1 186 ILE 186 221 221 ILE ILE F . n 
A 1 187 GLU 187 222 222 GLU GLU F . n 
A 1 188 PHE 188 223 223 PHE PHE F . n 
A 1 189 GLN 189 224 224 GLN GLN F . n 
A 1 190 GLN 190 225 225 GLN GLN F . n 
A 1 191 LYS 191 226 226 LYS LYS F . n 
A 1 192 ASN 192 227 227 ASN ASN F . n 
A 1 193 ASN 193 228 228 ASN ASN F . n 
A 1 194 ARG 194 229 229 ARG ARG F . n 
A 1 195 LEU 195 230 230 LEU LEU F . n 
A 1 196 LEU 196 231 231 LEU LEU F . n 
A 1 197 GLU 197 232 232 GLU GLU F . n 
A 1 198 ILE 198 233 233 ILE ILE F . n 
A 1 199 THR 199 234 234 THR THR F . n 
A 1 200 ARG 200 235 235 ARG ARG F . n 
A 1 201 GLU 201 236 236 GLU GLU F . n 
A 1 202 PHE 202 237 237 PHE PHE F . n 
A 1 203 SER 203 238 238 SER SER F . n 
A 1 204 VAL 204 239 239 VAL VAL F . n 
A 1 205 ASN 205 240 240 ASN ASN F . n 
A 1 206 ALA 206 241 241 ALA ALA F . n 
A 1 207 GLY 207 242 242 GLY GLY F . n 
A 1 208 VAL 208 243 243 VAL VAL F . n 
A 1 209 THR 209 244 244 THR THR F . n 
A 1 210 THR 210 245 245 THR THR F . n 
A 1 211 PRO 211 246 246 PRO PRO F . n 
A 1 212 VAL 212 247 247 VAL VAL F . n 
A 1 213 SER 213 248 248 SER SER F . n 
A 1 214 THR 214 249 249 THR THR F . n 
A 1 215 TYR 215 250 250 TYR TYR F . n 
A 1 216 MET 216 251 251 MET MET F . n 
A 1 217 LEU 217 252 252 LEU LEU F . n 
A 1 218 THR 218 253 253 THR THR F . n 
A 1 219 ASN 219 254 254 ASN ASN F . n 
A 1 220 SER 220 255 255 SER SER F . n 
A 1 221 GLU 221 256 256 GLU GLU F . n 
A 1 222 LEU 222 257 257 LEU LEU F . n 
A 1 223 LEU 223 258 258 LEU LEU F . n 
A 1 224 SER 224 259 259 SER SER F . n 
A 1 225 LEU 225 260 260 LEU LEU F . n 
A 1 226 ILE 226 261 261 ILE ILE F . n 
A 1 227 ASN 227 262 262 ASN ASN F . n 
A 1 228 ASP 228 263 263 ASP ASP F . n 
A 1 229 MET 229 264 264 MET MET F . n 
A 1 230 PRO 230 265 265 PRO PRO F . n 
A 1 231 ILE 231 266 266 ILE ILE F . n 
A 1 232 THR 232 267 267 THR THR F . n 
A 1 233 ASN 233 268 268 ASN ASN F . n 
A 1 234 ASP 234 269 269 ASP ASP F . n 
A 1 235 GLN 235 270 270 GLN GLN F . n 
A 1 236 LYS 236 271 271 LYS LYS F . n 
A 1 237 LYS 237 272 272 LYS LYS F . n 
A 1 238 LEU 238 273 273 LEU LEU F . n 
A 1 239 MET 239 274 274 MET MET F . n 
A 1 240 SER 240 275 275 SER SER F . n 
A 1 241 ASN 241 276 276 ASN ASN F . n 
A 1 242 ASN 242 277 277 ASN ASN F . n 
A 1 243 VAL 243 278 278 VAL VAL F . n 
A 1 244 GLN 244 279 279 GLN GLN F . n 
A 1 245 ILE 245 280 280 ILE ILE F . n 
A 1 246 VAL 246 281 281 VAL VAL F . n 
A 1 247 ARG 247 282 282 ARG ARG F . n 
A 1 248 GLN 248 283 283 GLN GLN F . n 
A 1 249 GLN 249 284 284 GLN GLN F . n 
A 1 250 SER 250 285 285 SER SER F . n 
A 1 251 TYR 251 286 286 TYR TYR F . n 
A 1 252 SER 252 287 287 SER SER F . n 
A 1 253 ILE 253 288 288 ILE ILE F . n 
A 1 254 MET 254 289 289 MET MET F . n 
A 1 255 CYS 255 290 290 CYS CYS F . n 
A 1 256 ILE 256 291 291 ILE ILE F . n 
A 1 257 ILE 257 292 292 ILE ILE F . n 
A 1 258 LYS 258 293 293 LYS LYS F . n 
A 1 259 GLU 259 294 294 GLU GLU F . n 
A 1 260 GLU 260 295 295 GLU GLU F . n 
A 1 261 VAL 261 296 296 VAL VAL F . n 
A 1 262 LEU 262 297 297 LEU LEU F . n 
A 1 263 ALA 263 298 298 ALA ALA F . n 
A 1 264 TYR 264 299 299 TYR TYR F . n 
A 1 265 VAL 265 300 300 VAL VAL F . n 
A 1 266 VAL 266 301 301 VAL VAL F . n 
A 1 267 GLN 267 302 302 GLN GLN F . n 
A 1 268 LEU 268 303 303 LEU LEU F . n 
A 1 269 PRO 269 304 304 PRO PRO F . n 
A 1 270 LEU 270 305 305 LEU LEU F . n 
A 1 271 TYR 271 306 306 TYR TYR F . n 
A 1 272 GLY 272 307 307 GLY GLY F . n 
A 1 273 VAL 273 308 308 VAL VAL F . n 
A 1 274 ILE 274 309 309 ILE ILE F . n 
A 1 275 ASP 275 310 310 ASP ASP F . n 
A 1 276 THR 276 311 311 THR THR F . n 
A 1 277 PRO 277 312 312 PRO PRO F . n 
A 1 278 CYS 278 313 313 CYS CYS F . n 
A 1 279 TRP 279 314 314 TRP TRP F . n 
A 1 280 LYS 280 315 315 LYS LYS F . n 
A 1 281 LEU 281 316 316 LEU LEU F . n 
A 1 282 HIS 282 317 317 HIS HIS F . n 
A 1 283 THR 283 318 318 THR THR F . n 
A 1 284 SER 284 319 319 SER SER F . n 
A 1 285 PRO 285 320 320 PRO PRO F . n 
A 1 286 LEU 286 321 321 LEU LEU F . n 
A 1 287 CYS 287 322 322 CYS CYS F . n 
A 1 288 THR 288 323 323 THR THR F . n 
A 1 289 THR 289 324 324 THR THR F . n 
A 1 290 ASN 290 325 325 ASN ASN F . n 
A 1 291 THR 291 326 326 THR THR F . n 
A 1 292 LYS 292 327 327 LYS LYS F . n 
A 1 293 GLU 293 328 328 GLU GLU F . n 
A 1 294 GLY 294 329 329 GLY GLY F . n 
A 1 295 SER 295 330 330 SER SER F . n 
A 1 296 ASN 296 331 331 ASN ASN F . n 
A 1 297 ILE 297 332 332 ILE ILE F . n 
A 1 298 CYS 298 333 333 CYS CYS F . n 
A 1 299 LEU 299 334 334 LEU LEU F . n 
A 1 300 THR 300 335 335 THR THR F . n 
A 1 301 ARG 301 336 336 ARG ARG F . n 
A 1 302 THR 302 337 337 THR THR F . n 
A 1 303 ASP 303 338 338 ASP ASP F . n 
A 1 304 ARG 304 339 339 ARG ARG F . n 
A 1 305 GLY 305 340 340 GLY GLY F . n 
A 1 306 TRP 306 341 341 TRP TRP F . n 
A 1 307 TYR 307 342 342 TYR TYR F . n 
A 1 308 CYS 308 343 343 CYS CYS F . n 
A 1 309 ASP 309 344 344 ASP ASP F . n 
A 1 310 ASN 310 345 345 ASN ASN F . n 
A 1 311 ALA 311 346 346 ALA ALA F . n 
A 1 312 GLY 312 347 347 GLY GLY F . n 
A 1 313 SER 313 348 348 SER SER F . n 
A 1 314 VAL 314 349 349 VAL VAL F . n 
A 1 315 SER 315 350 350 SER SER F . n 
A 1 316 PHE 316 351 351 PHE PHE F . n 
A 1 317 PHE 317 352 352 PHE PHE F . n 
A 1 318 PRO 318 353 353 PRO PRO F . n 
A 1 319 GLN 319 354 354 GLN GLN F . n 
A 1 320 ALA 320 355 355 ALA ALA F . n 
A 1 321 GLU 321 356 356 GLU GLU F . n 
A 1 322 THR 322 357 357 THR THR F . n 
A 1 323 CYS 323 358 358 CYS CYS F . n 
A 1 324 LYS 324 359 359 LYS LYS F . n 
A 1 325 VAL 325 360 360 VAL VAL F . n 
A 1 326 GLN 326 361 361 GLN GLN F . n 
A 1 327 SER 327 362 362 SER SER F . n 
A 1 328 ASN 328 363 363 ASN ASN F . n 
A 1 329 ARG 329 364 364 ARG ARG F . n 
A 1 330 VAL 330 365 365 VAL VAL F . n 
A 1 331 PHE 331 366 366 PHE PHE F . n 
A 1 332 CYS 332 367 367 CYS CYS F . n 
A 1 333 ASP 333 368 368 ASP ASP F . n 
A 1 334 THR 334 369 369 THR THR F . n 
A 1 335 MET 335 370 370 MET MET F . n 
A 1 336 ASN 336 371 371 ASN ASN F . n 
A 1 337 SER 337 372 372 SER SER F . n 
A 1 338 LEU 338 373 373 LEU LEU F . n 
A 1 339 THR 339 374 374 THR THR F . n 
A 1 340 LEU 340 375 375 LEU LEU F . n 
A 1 341 PRO 341 376 376 PRO PRO F . n 
A 1 342 SER 342 377 377 SER SER F . n 
A 1 343 GLU 343 378 378 GLU GLU F . n 
A 1 344 VAL 344 379 379 VAL VAL F . n 
A 1 345 ASN 345 380 380 ASN ASN F . n 
A 1 346 LEU 346 381 381 LEU LEU F . n 
A 1 347 CYS 347 382 382 CYS CYS F . n 
A 1 348 ASN 348 383 383 ASN ASN F . n 
A 1 349 VAL 349 384 384 VAL VAL F . n 
A 1 350 ASP 350 385 385 ASP ASP F . n 
A 1 351 ILE 351 386 386 ILE ILE F . n 
A 1 352 PHE 352 387 387 PHE PHE F . n 
A 1 353 ASN 353 388 388 ASN ASN F . n 
A 1 354 PRO 354 389 389 PRO PRO F . n 
A 1 355 LYS 355 390 390 LYS LYS F . n 
A 1 356 TYR 356 391 391 TYR TYR F . n 
A 1 357 ASP 357 392 392 ASP ASP F . n 
A 1 358 CYS 358 393 393 CYS CYS F . n 
A 1 359 LYS 359 394 394 LYS LYS F . n 
A 1 360 ILE 360 395 395 ILE ILE F . n 
A 1 361 MET 361 396 396 MET MET F . n 
A 1 362 THR 362 397 397 THR THR F . n 
A 1 363 SER 363 398 398 SER SER F . n 
A 1 364 LYS 364 399 399 LYS LYS F . n 
A 1 365 THR 365 400 400 THR THR F . n 
A 1 366 ASP 366 401 401 ASP ASP F . n 
A 1 367 VAL 367 402 402 VAL VAL F . n 
A 1 368 SER 368 403 403 SER SER F . n 
A 1 369 SER 369 404 404 SER SER F . n 
A 1 370 SER 370 405 405 SER SER F . n 
A 1 371 VAL 371 406 406 VAL VAL F . n 
A 1 372 ILE 372 407 407 ILE ILE F . n 
A 1 373 THR 373 408 408 THR THR F . n 
A 1 374 SER 374 409 409 SER SER F . n 
A 1 375 LEU 375 410 410 LEU LEU F . n 
A 1 376 GLY 376 411 411 GLY GLY F . n 
A 1 377 ALA 377 412 412 ALA ALA F . n 
A 1 378 ILE 378 413 413 ILE ILE F . n 
A 1 379 VAL 379 414 414 VAL VAL F . n 
A 1 380 SER 380 415 415 SER SER F . n 
A 1 381 CYS 381 416 416 CYS CYS F . n 
A 1 382 TYR 382 417 417 TYR TYR F . n 
A 1 383 GLY 383 418 418 GLY GLY F . n 
A 1 384 LYS 384 419 419 LYS LYS F . n 
A 1 385 THR 385 420 420 THR THR F . n 
A 1 386 LYS 386 421 421 LYS LYS F . n 
A 1 387 CYS 387 422 422 CYS CYS F . n 
A 1 388 THR 388 423 423 THR THR F . n 
A 1 389 ALA 389 424 424 ALA ALA F . n 
A 1 390 SER 390 425 425 SER SER F . n 
A 1 391 ASN 391 426 426 ASN ASN F . n 
A 1 392 LYS 392 427 427 LYS LYS F . n 
A 1 393 ASN 393 428 428 ASN ASN F . n 
A 1 394 ARG 394 429 429 ARG ARG F . n 
A 1 395 GLY 395 430 430 GLY GLY F . n 
A 1 396 ILE 396 431 431 ILE ILE F . n 
A 1 397 ILE 397 432 432 ILE ILE F . n 
A 1 398 LYS 398 433 433 LYS LYS F . n 
A 1 399 THR 399 434 434 THR THR F . n 
A 1 400 PHE 400 435 435 PHE PHE F . n 
A 1 401 SER 401 436 436 SER SER F . n 
A 1 402 ASN 402 437 437 ASN ASN F . n 
A 1 403 GLY 403 438 438 GLY GLY F . n 
A 1 404 CYS 404 439 439 CYS CYS F . n 
A 1 405 ASP 405 440 440 ASP ASP F . n 
A 1 406 TYR 406 441 441 TYR TYR F . n 
A 1 407 VAL 407 442 442 VAL VAL F . n 
A 1 408 SER 408 443 443 SER SER F . n 
A 1 409 ASN 409 444 444 ASN ASN F . n 
A 1 410 LYS 410 445 445 LYS LYS F . n 
A 1 411 GLY 411 446 446 GLY GLY F . n 
A 1 412 VAL 412 447 447 VAL VAL F . n 
A 1 413 ASP 413 448 448 ASP ASP F . n 
A 1 414 THR 414 449 449 THR THR F . n 
A 1 415 VAL 415 450 450 VAL VAL F . n 
A 1 416 SER 416 451 451 SER SER F . n 
A 1 417 VAL 417 452 452 VAL VAL F . n 
A 1 418 GLY 418 453 453 GLY GLY F . n 
A 1 419 ASN 419 454 454 ASN ASN F . n 
A 1 420 THR 420 455 455 THR THR F . n 
A 1 421 LEU 421 456 456 LEU LEU F . n 
A 1 422 TYR 422 457 457 TYR TYR F . n 
A 1 423 TYR 423 458 458 TYR TYR F . n 
A 1 424 VAL 424 459 459 VAL VAL F . n 
A 1 425 ASN 425 460 460 ASN ASN F . n 
A 1 426 LYS 426 461 461 LYS LYS F . n 
A 1 427 GLN 427 462 462 GLN GLN F . n 
A 1 428 GLU 428 463 463 GLU GLU F . n 
A 1 429 GLY 429 464 464 GLY GLY F . n 
A 1 430 LYS 430 465 465 LYS LYS F . n 
A 1 431 SER 431 466 466 SER SER F . n 
A 1 432 LEU 432 467 467 LEU LEU F . n 
A 1 433 TYR 433 468 468 TYR TYR F . n 
A 1 434 VAL 434 469 469 VAL VAL F . n 
A 1 435 LYS 435 470 470 LYS LYS F . n 
A 1 436 GLY 436 471 471 GLY GLY F . n 
A 1 437 GLU 437 472 472 GLU GLU F . n 
A 1 438 PRO 438 473 473 PRO PRO F . n 
A 1 439 ILE 439 474 474 ILE ILE F . n 
A 1 440 ILE 440 475 475 ILE ILE F . n 
A 1 441 ASN 441 476 476 ASN ASN F . n 
A 1 442 PHE 442 477 477 PHE PHE F . n 
A 1 443 TYR 443 478 478 TYR TYR F . n 
A 1 444 ASP 444 479 479 ASP ASP F . n 
A 1 445 PRO 445 480 480 PRO PRO F . n 
A 1 446 LEU 446 481 481 LEU LEU F . n 
A 1 447 VAL 447 482 482 VAL VAL F . n 
A 1 448 PHE 448 483 483 PHE PHE F . n 
A 1 449 PRO 449 484 484 PRO PRO F . n 
A 1 450 SER 450 485 485 SER SER F . n 
A 1 451 ASN 451 486 486 ASN ASN F . n 
A 1 452 GLN 452 487 487 GLN GLN F . n 
A 1 453 PHE 453 488 488 PHE PHE F . n 
A 1 454 ASP 454 489 489 ASP ASP F . n 
A 1 455 ALA 455 490 490 ALA ALA F . n 
A 1 456 SER 456 491 491 SER SER F . n 
A 1 457 ILE 457 492 492 ILE ILE F . n 
A 1 458 SER 458 493 493 SER SER F . n 
A 1 459 GLN 459 494 494 GLN GLN F . n 
A 1 460 VAL 460 495 495 VAL VAL F . n 
A 1 461 ASN 461 496 496 ASN ASN F . n 
A 1 462 GLU 462 497 497 GLU GLU F . n 
A 1 463 LYS 463 498 498 LYS LYS F . n 
A 1 464 ILE 464 499 499 ILE ILE F . n 
A 1 465 ASN 465 500 500 ASN ASN F . n 
A 1 466 GLN 466 501 501 GLN GLN F . n 
A 1 467 SER 467 502 502 SER SER F . n 
A 1 468 LEU 468 503 503 LEU LEU F . n 
A 1 469 ALA 469 504 504 ALA ALA F . n 
A 1 470 PHE 470 505 505 PHE PHE F . n 
A 1 471 ILE 471 506 506 ILE ILE F . n 
A 1 472 ARG 472 507 507 ARG ARG F . n 
A 1 473 LYS 473 508 508 LYS LYS F . n 
A 1 474 SER 474 509 509 SER SER F . n 
A 1 475 ASP 475 510 ?   ?   ?   F . n 
A 1 476 GLU 476 511 ?   ?   ?   F . n 
A 1 477 LEU 477 512 ?   ?   ?   F . n 
A 1 478 LEU 478 513 ?   ?   ?   F . n 
A 1 479 ALA 479 514 ?   ?   ?   F . n 
A 1 480 SER 480 515 ?   ?   ?   F . n 
A 1 481 GLY 481 516 ?   ?   ?   F . n 
A 1 482 TYR 482 517 ?   ?   ?   F . n 
A 1 483 ILE 483 518 ?   ?   ?   F . n 
A 1 484 PRO 484 519 ?   ?   ?   F . n 
A 1 485 GLU 485 520 ?   ?   ?   F . n 
A 1 486 ALA 486 521 ?   ?   ?   F . n 
A 1 487 PRO 487 522 ?   ?   ?   F . n 
A 1 488 ARG 488 523 ?   ?   ?   F . n 
A 1 489 ASP 489 524 ?   ?   ?   F . n 
A 1 490 GLY 490 525 ?   ?   ?   F . n 
A 1 491 GLN 491 526 ?   ?   ?   F . n 
A 1 492 ALA 492 527 ?   ?   ?   F . n 
A 1 493 TYR 493 528 ?   ?   ?   F . n 
A 1 494 VAL 494 529 ?   ?   ?   F . n 
A 1 495 ARG 495 530 ?   ?   ?   F . n 
A 1 496 LYS 496 531 ?   ?   ?   F . n 
A 1 497 ASP 497 532 ?   ?   ?   F . n 
A 1 498 GLY 498 533 ?   ?   ?   F . n 
A 1 499 GLU 499 534 ?   ?   ?   F . n 
A 1 500 TRP 500 535 ?   ?   ?   F . n 
A 1 501 VAL 501 536 ?   ?   ?   F . n 
A 1 502 LEU 502 537 ?   ?   ?   F . n 
A 1 503 LEU 503 538 ?   ?   ?   F . n 
A 1 504 SER 504 539 ?   ?   ?   F . n 
A 1 505 THR 505 540 ?   ?   ?   F . n 
A 1 506 PHE 506 541 ?   ?   ?   F . n 
A 1 507 LEU 507 542 ?   ?   ?   F . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 EDO 1  601 540 EDO EDO F . 
C 3 NAG 1  602 541 NAG NAG F . 
D 4 HOH 1  701 23  HOH HOH F . 
D 4 HOH 2  702 16  HOH HOH F . 
D 4 HOH 3  703 60  HOH HOH F . 
D 4 HOH 4  704 63  HOH HOH F . 
D 4 HOH 5  705 9   HOH HOH F . 
D 4 HOH 6  706 55  HOH HOH F . 
D 4 HOH 7  707 19  HOH HOH F . 
D 4 HOH 8  708 21  HOH HOH F . 
D 4 HOH 9  709 51  HOH HOH F . 
D 4 HOH 10 710 6   HOH HOH F . 
D 4 HOH 11 711 20  HOH HOH F . 
D 4 HOH 12 712 26  HOH HOH F . 
D 4 HOH 13 713 17  HOH HOH F . 
D 4 HOH 14 714 46  HOH HOH F . 
D 4 HOH 15 715 10  HOH HOH F . 
D 4 HOH 16 716 34  HOH HOH F . 
D 4 HOH 17 717 27  HOH HOH F . 
D 4 HOH 18 718 15  HOH HOH F . 
D 4 HOH 19 719 2   HOH HOH F . 
D 4 HOH 20 720 38  HOH HOH F . 
D 4 HOH 21 721 8   HOH HOH F . 
D 4 HOH 22 722 33  HOH HOH F . 
D 4 HOH 23 723 57  HOH HOH F . 
D 4 HOH 24 724 59  HOH HOH F . 
D 4 HOH 25 725 53  HOH HOH F . 
D 4 HOH 26 726 54  HOH HOH F . 
D 4 HOH 27 727 14  HOH HOH F . 
D 4 HOH 28 728 47  HOH HOH F . 
D 4 HOH 29 729 12  HOH HOH F . 
D 4 HOH 30 730 1   HOH HOH F . 
D 4 HOH 31 731 43  HOH HOH F . 
D 4 HOH 32 732 24  HOH HOH F . 
D 4 HOH 33 733 30  HOH HOH F . 
D 4 HOH 34 734 22  HOH HOH F . 
D 4 HOH 35 735 3   HOH HOH F . 
D 4 HOH 36 736 28  HOH HOH F . 
D 4 HOH 37 737 5   HOH HOH F . 
D 4 HOH 38 738 37  HOH HOH F . 
D 4 HOH 39 739 42  HOH HOH F . 
D 4 HOH 40 740 7   HOH HOH F . 
D 4 HOH 41 741 25  HOH HOH F . 
D 4 HOH 42 742 48  HOH HOH F . 
D 4 HOH 43 743 56  HOH HOH F . 
D 4 HOH 44 744 36  HOH HOH F . 
D 4 HOH 45 745 44  HOH HOH F . 
D 4 HOH 46 746 45  HOH HOH F . 
D 4 HOH 47 747 52  HOH HOH F . 
D 4 HOH 48 748 41  HOH HOH F . 
D 4 HOH 49 749 39  HOH HOH F . 
D 4 HOH 50 750 4   HOH HOH F . 
D 4 HOH 51 751 32  HOH HOH F . 
D 4 HOH 52 752 18  HOH HOH F . 
D 4 HOH 53 753 49  HOH HOH F . 
D 4 HOH 54 754 35  HOH HOH F . 
D 4 HOH 55 755 31  HOH HOH F . 
D 4 HOH 56 756 62  HOH HOH F . 
D 4 HOH 57 757 11  HOH HOH F . 
D 4 HOH 58 758 50  HOH HOH F . 
D 4 HOH 59 759 61  HOH HOH F . 
D 4 HOH 60 760 58  HOH HOH F . 
D 4 HOH 61 761 40  HOH HOH F . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W3F 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     168.183 
_cell.length_a_esd                 ? 
_cell.length_b                     168.183 
_cell.length_b_esd                 ? 
_cell.length_c                     168.183 
_cell.length_c_esd                 ? 
_cell.volume                       4757143.861 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W3F 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                213 
_symmetry.space_group_name_Hall            'P 4bd 2ab 3' 
_symmetry.space_group_name_H-M             'P 41 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8W3F 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.56 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          65.43 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M tri-Potassium citrate, 20% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-11-04 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          47.55 
_reflns.entry_id                                       8W3F 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.7 
_reflns.d_resolution_low                               48.55 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     22950 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.89 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                16.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.87 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.7 
_reflns_shell.d_res_low                                     2.797 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2248 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.697 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               48.74 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8W3F 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.70 
_refine.ls_d_res_low                             48.55 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22950 
_refine.ls_number_reflns_R_free                  1122 
_refine.ls_number_reflns_R_work                  21828 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.91 
_refine.ls_percent_reflns_R_free                 4.89 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2333 
_refine.ls_R_factor_R_free                       0.2749 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2313 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.6413 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.4153 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.70 
_refine_hist.d_res_low                        48.55 
_refine_hist.number_atoms_solvent             61 
_refine_hist.number_atoms_total               3512 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3433 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         18 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0116  ? 3507 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.5326  ? 4756 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0876  ? 576  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0143  ? 600  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.2556 ? 1306 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.70 2.82  . . 145 2654 99.96  . . . . 0.3426 . . . . . . . . . . . 0.3798 
'X-RAY DIFFRACTION' 2.82 2.97  . . 144 2663 99.82  . . . . 0.3184 . . . . . . . . . . . 0.3745 
'X-RAY DIFFRACTION' 2.97 3.16  . . 135 2670 99.96  . . . . 0.2825 . . . . . . . . . . . 0.3236 
'X-RAY DIFFRACTION' 3.16 3.40  . . 150 2692 100.00 . . . . 0.2588 . . . . . . . . . . . 0.3141 
'X-RAY DIFFRACTION' 3.40 3.74  . . 143 2703 99.96  . . . . 0.2459 . . . . . . . . . . . 0.2934 
'X-RAY DIFFRACTION' 3.74 4.28  . . 134 2717 99.96  . . . . 0.2269 . . . . . . . . . . . 0.2899 
'X-RAY DIFFRACTION' 4.28 5.39  . . 142 2770 100.00 . . . . 0.1723 . . . . . . . . . . . 0.1969 
'X-RAY DIFFRACTION' 5.39 48.55 . . 129 2959 99.61  . . . . 0.1983 . . . . . . . . . . . 0.2196 
# 
_struct.entry_id                     8W3F 
_struct.title                        'Crystal structure of prefusion-stabilized RSV F protein UFCR1-P2-NQ' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W3F 
_struct_keywords.text            'Respiratory syncytial virus, glycoprotein, prefusion vaccine, stabilized, viral protein' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8W3F 
_struct_ref.pdbx_db_accession          8W3F 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8W3F 
_struct_ref_seq.pdbx_strand_id                F 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 507 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8W3F 
_struct_ref_seq.db_align_beg                  -3 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  542 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -3 
_struct_ref_seq.pdbx_auth_seq_align_end       542 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 12400 ? 
1 MORE         -16   ? 
1 'SSA (A^2)'  55030 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000 0.0000000000 0.0000000000 0.0000000000    0.0000000000 1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000    
2 'crystal symmetry operation' 5_663 z+1,x+1,y-2 0.0000000000 0.0000000000 1.0000000000 168.1830000000  1.0000000000 0.0000000000 
0.0000000000 168.1830000000 0.0000000000 1.0000000000 0.0000000000 -336.3660000000 
3 'crystal symmetry operation' 9_474 y-1,z+2,x-1 0.0000000000 1.0000000000 0.0000000000 -168.1830000000 0.0000000000 0.0000000000 
1.0000000000 336.3660000000 1.0000000000 0.0000000000 0.0000000000 -168.1830000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 77  ? SER A 103 ? ASP F 73  SER F 99  1 ? 27 
HELX_P HELX_P2  AA2 ILE A 113 ? HIS A 124 ? ILE F 148 HIS F 159 1 ? 12 
HELX_P HELX_P3  AA3 GLY A 127 ? LEU A 136 ? GLY F 162 LEU F 171 1 ? 10 
HELX_P HELX_P4  AA4 LEU A 160 ? LEU A 168 ? LEU F 195 LEU F 203 1 ? 9  
HELX_P HELX_P5  AA5 LEU A 168 ? ASN A 173 ? LEU F 203 ASN F 208 1 ? 6  
HELX_P HELX_P6  AA6 ASN A 181 ? ASN A 205 ? ASN F 216 ASN F 240 1 ? 25 
HELX_P HELX_P7  AA7 THR A 218 ? ASP A 228 ? THR F 253 ASP F 263 1 ? 11 
HELX_P HELX_P8  AA8 THR A 232 ? ASN A 242 ? THR F 267 ASN F 277 1 ? 11 
HELX_P HELX_P9  AA9 ASN A 242 ? GLN A 249 ? ASN F 277 GLN F 284 1 ? 8  
HELX_P HELX_P10 AB1 GLN A 319 ? GLU A 321 ? GLN F 354 GLU F 356 5 ? 3  
HELX_P HELX_P11 AB2 MET A 335 ? SER A 337 ? MET F 370 SER F 372 5 ? 3  
HELX_P HELX_P12 AB3 PRO A 341 ? VAL A 349 ? PRO F 376 VAL F 384 5 ? 9  
HELX_P HELX_P13 AB4 PRO A 438 ? TYR A 443 ? PRO F 473 TYR F 478 5 ? 6  
HELX_P HELX_P14 AB5 ASP A 444 ? PHE A 448 ? ASP F 479 PHE F 483 5 ? 5  
HELX_P HELX_P15 AB6 ILE A 457 ? LYS A 473 ? ILE F 492 LYS F 508 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 41  SG  ? ? ? 1_555 A CYS 404 SG ? ? F CYS 37  F CYS 439 1_555 ? ? ? ? ? ? ? 2.024 ? ?               
disulf2 disulf ?   ? A CYS 73  SG  ? ? ? 1_555 A CYS 177 SG ? ? F CYS 69  F CYS 212 1_555 ? ? ? ? ? ? ? 2.048 ? ?               
disulf3 disulf ?   ? A CYS 120 SG  ? ? ? 1_555 A CYS 255 SG ? ? F CYS 155 F CYS 290 1_555 ? ? ? ? ? ? ? 2.065 ? ?               
disulf4 disulf ?   ? A CYS 278 SG  ? ? ? 1_555 A CYS 308 SG ? ? F CYS 313 F CYS 343 1_555 ? ? ? ? ? ? ? 2.083 ? ?               
disulf5 disulf ?   ? A CYS 287 SG  ? ? ? 1_555 A CYS 298 SG ? ? F CYS 322 F CYS 333 1_555 ? ? ? ? ? ? ? 2.017 ? ?               
disulf6 disulf ?   ? A CYS 323 SG  ? ? ? 1_555 A CYS 332 SG ? ? F CYS 358 F CYS 367 1_555 ? ? ? ? ? ? ? 2.073 ? ?               
disulf7 disulf ?   ? A CYS 347 SG  ? ? ? 1_555 A CYS 358 SG ? ? F CYS 382 F CYS 393 1_555 ? ? ? ? ? ? ? 2.072 ? ?               
disulf8 disulf ?   ? A CYS 381 SG  ? ? ? 1_555 A CYS 387 SG ? ? F CYS 416 F CYS 422 1_555 ? ? ? ? ? ? ? 2.092 ? ?               
covale1 covale one ? A ASN 465 ND2 ? ? ? 1_555 C NAG .   C1 ? ? F ASN 500 F NAG 602 1_555 ? ? ? ? ? ? ? 1.459 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG C .   ? ASN A 465 ? NAG F 602 ? 1_555 ASN F 500 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 CYS A 41  ? CYS A 404 ? CYS F 37  ? 1_555 CYS F 439 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3 CYS A 73  ? CYS A 177 ? CYS F 69  ? 1_555 CYS F 212 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4 CYS A 120 ? CYS A 255 ? CYS F 155 ? 1_555 CYS F 290 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5 CYS A 278 ? CYS A 308 ? CYS F 313 ? 1_555 CYS F 343 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6 CYS A 287 ? CYS A 298 ? CYS F 322 ? 1_555 CYS F 333 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7 CYS A 323 ? CYS A 332 ? CYS F 358 ? 1_555 CYS F 367 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8 CYS A 347 ? CYS A 358 ? CYS F 382 ? 1_555 CYS F 393 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9 CYS A 381 ? CYS A 387 ? CYS F 416 ? 1_555 CYS F 422 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          THR 
_struct_mon_prot_cis.label_seq_id           210 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           THR 
_struct_mon_prot_cis.auth_seq_id            245 
_struct_mon_prot_cis.auth_asym_id           F 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    211 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     246 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    F 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.32 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 6 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? parallel      
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA1 2 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA1 3 SER A 42  ? ARG A 53  ? SER F 38  ARG F 49  
AA1 4 VAL A 273 ? THR A 283 ? VAL F 308 THR F 318 
AA1 5 GLY A 305 ? ASN A 310 ? GLY F 340 ASN F 345 
AA1 6 SER A 313 ? PHE A 317 ? SER F 348 PHE F 352 
AA1 7 LEU A 338 ? LEU A 340 ? LEU F 373 LEU F 375 
AA2 1 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA2 2 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA2 3 SER A 42  ? ARG A 53  ? SER F 38  ARG F 49  
AA2 4 THR A 33  ? TYR A 37  ? THR F 29  TYR F 33  
AA2 5 LYS A 430 ? VAL A 434 ? LYS F 465 VAL F 469 
AA3 1 LYS A 141 ? SER A 145 ? LYS F 176 SER F 180 
AA3 2 SER A 151 ? ASP A 159 ? SER F 186 ASP F 194 
AA3 3 GLY A 55  ? GLU A 64  ? GLY F 51  GLU F 60  
AA3 4 VAL A 261 ? LEU A 270 ? VAL F 296 LEU F 305 
AA3 5 TYR A 251 ? ILE A 257 ? TYR F 286 ILE F 292 
AA3 6 VAL A 208 ? THR A 209 ? VAL F 243 THR F 244 
AA4 1 LEU A 286 ? CYS A 287 ? LEU F 321 CYS F 322 
AA4 2 CYS A 298 ? ARG A 301 ? CYS F 333 ARG F 336 
AA4 3 LYS A 359 ? SER A 363 ? LYS F 394 SER F 398 
AA4 4 ALA A 455 ? SER A 456 ? ALA F 490 SER F 491 
AA5 1 SER A 369 ? ILE A 372 ? SER F 404 ILE F 407 
AA5 2 GLY A 376 ? CYS A 381 ? GLY F 411 CYS F 416 
AA5 3 GLY A 403 ? SER A 408 ? GLY F 438 SER F 443 
AA6 1 GLY A 395 ? THR A 399 ? GLY F 430 THR F 434 
AA6 2 CYS A 387 ? ASN A 391 ? CYS F 422 ASN F 426 
AA6 3 THR A 414 ? VAL A 417 ? THR F 449 VAL F 452 
AA6 4 THR A 420 ? TYR A 423 ? THR F 455 TYR F 458 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LYS A 324 ? N LYS F 359 O PHE A 331 ? O PHE F 366 
AA1 2 3 O CYS A 332 ? O CYS F 367 N ARG A 53  ? N ARG F 49  
AA1 3 4 N ALA A 43  ? N ALA F 39  O HIS A 282 ? O HIS F 317 
AA1 4 5 N LEU A 281 ? N LEU F 316 O GLY A 305 ? O GLY F 340 
AA1 5 6 N CYS A 308 ? N CYS F 343 O SER A 315 ? O SER F 350 
AA1 6 7 N PHE A 316 ? N PHE F 351 O LEU A 338 ? O LEU F 373 
AA2 1 2 N LYS A 324 ? N LYS F 359 O PHE A 331 ? O PHE F 366 
AA2 2 3 O CYS A 332 ? O CYS F 367 N ARG A 53  ? N ARG F 49  
AA2 3 4 O SER A 42  ? O SER F 38  N TYR A 37  ? N TYR F 33  
AA2 4 5 N PHE A 36  ? N PHE F 32  O VAL A 434 ? O VAL F 469 
AA3 1 2 N VAL A 144 ? N VAL F 179 O VAL A 152 ? O VAL F 187 
AA3 2 3 O SER A 155 ? O SER F 190 N THR A 62  ? N THR F 58  
AA3 3 4 N TYR A 57  ? N TYR F 53  O LEU A 268 ? O LEU F 303 
AA3 4 5 O VAL A 265 ? O VAL F 300 N ILE A 253 ? N ILE F 288 
AA3 5 6 O SER A 252 ? O SER F 287 N THR A 209 ? N THR F 244 
AA4 1 2 N LEU A 286 ? N LEU F 321 O LEU A 299 ? O LEU F 334 
AA4 2 3 N CYS A 298 ? N CYS F 333 O SER A 363 ? O SER F 398 
AA4 3 4 N ILE A 360 ? N ILE F 395 O ALA A 455 ? O ALA F 490 
AA5 1 2 N SER A 369 ? N SER F 404 O SER A 380 ? O SER F 415 
AA5 2 3 N VAL A 379 ? N VAL F 414 O ASP A 405 ? O ASP F 440 
AA6 1 2 O ILE A 397 ? O ILE F 432 N ALA A 389 ? N ALA F 424 
AA6 2 3 N THR A 388 ? N THR F 423 O SER A 416 ? O SER F 451 
AA6 3 4 N VAL A 415 ? N VAL F 450 O TYR A 422 ? O TYR F 457 
# 
_pdbx_entry_details.entry_id                   8W3F 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OD1 
_pdbx_validate_symm_contact.auth_asym_id_1    F 
_pdbx_validate_symm_contact.auth_comp_id_1    ASP 
_pdbx_validate_symm_contact.auth_seq_id_1     73 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    OD1 
_pdbx_validate_symm_contact.auth_asym_id_2    F 
_pdbx_validate_symm_contact.auth_comp_id_2    ASP 
_pdbx_validate_symm_contact.auth_seq_id_2     73 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   24_585 
_pdbx_validate_symm_contact.dist              1.99 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN F 70  ? ? -57.73  106.60  
2 1 THR F 72  ? ? -141.89 -8.89   
3 1 LEU F 171 ? ? -92.95  33.38   
4 1 ASN F 208 ? ? -110.90 59.87   
5 1 CYS F 290 ? ? -95.64  -99.88  
6 1 SER F 362 ? ? 68.48   -112.27 
7 1 ASN F 371 ? ? -115.42 64.69   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  x+1/4,-z+1/4,y+3/4   
3  x+3/4,z+1/4,-y+1/4   
4  z+3/4,y+1/4,-x+1/4   
5  -z+1/4,y+3/4,x+1/4   
6  -y+1/4,x+3/4,z+1/4   
7  y+1/4,-x+1/4,z+3/4   
8  z,x,y                
9  y,z,x                
10 -y+1/2,-z,x+1/2      
11 z+1/2,-x+1/2,-y      
12 -y,z+1/2,-x+1/2      
13 -z+1/2,-x,y+1/2      
14 -z,x+1/2,-y+1/2      
15 y+1/2,-z+1/2,-x      
16 x+1/2,-y+1/2,-z      
17 -x,y+1/2,-z+1/2      
18 -x+1/2,-y,z+1/2      
19 y+3/4,x+1/4,-z+1/4   
20 -y+3/4,-x+3/4,-z+3/4 
21 z+1/4,-y+1/4,x+3/4   
22 -z+3/4,-y+3/4,-x+3/4 
23 -x+1/4,z+3/4,y+1/4   
24 -x+3/4,-z+3/4,-y+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 F MET -3  ? A MET 1   
2  1 Y 1 F GLY -2  ? A GLY 2   
3  1 Y 1 F ILE -1  ? A ILE 3   
4  1 Y 1 F LEU 0   ? A LEU 4   
5  1 Y 1 F PRO 1   ? A PRO 5   
6  1 Y 1 F SER 2   ? A SER 6   
7  1 Y 1 F PRO 3   ? A PRO 7   
8  1 Y 1 F GLY 4   ? A GLY 8   
9  1 Y 1 F MET 5   ? A MET 9   
10 1 Y 1 F PRO 6   ? A PRO 10  
11 1 Y 1 F ALA 7   ? A ALA 11  
12 1 Y 1 F LEU 8   ? A LEU 12  
13 1 Y 1 F LEU 9   ? A LEU 13  
14 1 Y 1 F SER 10  ? A SER 14  
15 1 Y 1 F LEU 11  ? A LEU 15  
16 1 Y 1 F VAL 12  ? A VAL 16  
17 1 Y 1 F SER 13  ? A SER 17  
18 1 Y 1 F LEU 14  ? A LEU 18  
19 1 Y 1 F LEU 15  ? A LEU 19  
20 1 Y 1 F SER 16  ? A SER 20  
21 1 Y 1 F VAL 17  ? A VAL 21  
22 1 Y 1 F LEU 18  ? A LEU 22  
23 1 Y 1 F LEU 19  ? A LEU 23  
24 1 Y 1 F MET 20  ? A MET 24  
25 1 Y 1 F GLY 21  ? A GLY 25  
26 1 Y 1 F CYS 22  ? A CYS 26  
27 1 Y 1 F VAL 23  ? A VAL 27  
28 1 Y 1 F ALA 24  ? A ALA 28  
29 1 Y 1 F GLU 25  ? A GLU 29  
30 1 Y 1 F ASP 510 ? A ASP 475 
31 1 Y 1 F GLU 511 ? A GLU 476 
32 1 Y 1 F LEU 512 ? A LEU 477 
33 1 Y 1 F LEU 513 ? A LEU 478 
34 1 Y 1 F ALA 514 ? A ALA 479 
35 1 Y 1 F SER 515 ? A SER 480 
36 1 Y 1 F GLY 516 ? A GLY 481 
37 1 Y 1 F TYR 517 ? A TYR 482 
38 1 Y 1 F ILE 518 ? A ILE 483 
39 1 Y 1 F PRO 519 ? A PRO 484 
40 1 Y 1 F GLU 520 ? A GLU 485 
41 1 Y 1 F ALA 521 ? A ALA 486 
42 1 Y 1 F PRO 522 ? A PRO 487 
43 1 Y 1 F ARG 523 ? A ARG 488 
44 1 Y 1 F ASP 524 ? A ASP 489 
45 1 Y 1 F GLY 525 ? A GLY 490 
46 1 Y 1 F GLN 526 ? A GLN 491 
47 1 Y 1 F ALA 527 ? A ALA 492 
48 1 Y 1 F TYR 528 ? A TYR 493 
49 1 Y 1 F VAL 529 ? A VAL 494 
50 1 Y 1 F ARG 530 ? A ARG 495 
51 1 Y 1 F LYS 531 ? A LYS 496 
52 1 Y 1 F ASP 532 ? A ASP 497 
53 1 Y 1 F GLY 533 ? A GLY 498 
54 1 Y 1 F GLU 534 ? A GLU 499 
55 1 Y 1 F TRP 535 ? A TRP 500 
56 1 Y 1 F VAL 536 ? A VAL 501 
57 1 Y 1 F LEU 537 ? A LEU 502 
58 1 Y 1 F LEU 538 ? A LEU 503 
59 1 Y 1 F SER 539 ? A SER 504 
60 1 Y 1 F THR 540 ? A THR 505 
61 1 Y 1 F PHE 541 ? A PHE 506 
62 1 Y 1 F LEU 542 ? A LEU 507 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EDO C1   C N N 88  
EDO O1   O N N 89  
EDO C2   C N N 90  
EDO O2   O N N 91  
EDO H11  H N N 92  
EDO H12  H N N 93  
EDO HO1  H N N 94  
EDO H21  H N N 95  
EDO H22  H N N 96  
EDO HO2  H N N 97  
GLN N    N N N 98  
GLN CA   C N S 99  
GLN C    C N N 100 
GLN O    O N N 101 
GLN CB   C N N 102 
GLN CG   C N N 103 
GLN CD   C N N 104 
GLN OE1  O N N 105 
GLN NE2  N N N 106 
GLN OXT  O N N 107 
GLN H    H N N 108 
GLN H2   H N N 109 
GLN HA   H N N 110 
GLN HB2  H N N 111 
GLN HB3  H N N 112 
GLN HG2  H N N 113 
GLN HG3  H N N 114 
GLN HE21 H N N 115 
GLN HE22 H N N 116 
GLN HXT  H N N 117 
GLU N    N N N 118 
GLU CA   C N S 119 
GLU C    C N N 120 
GLU O    O N N 121 
GLU CB   C N N 122 
GLU CG   C N N 123 
GLU CD   C N N 124 
GLU OE1  O N N 125 
GLU OE2  O N N 126 
GLU OXT  O N N 127 
GLU H    H N N 128 
GLU H2   H N N 129 
GLU HA   H N N 130 
GLU HB2  H N N 131 
GLU HB3  H N N 132 
GLU HG2  H N N 133 
GLU HG3  H N N 134 
GLU HE2  H N N 135 
GLU HXT  H N N 136 
GLY N    N N N 137 
GLY CA   C N N 138 
GLY C    C N N 139 
GLY O    O N N 140 
GLY OXT  O N N 141 
GLY H    H N N 142 
GLY H2   H N N 143 
GLY HA2  H N N 144 
GLY HA3  H N N 145 
GLY HXT  H N N 146 
HIS N    N N N 147 
HIS CA   C N S 148 
HIS C    C N N 149 
HIS O    O N N 150 
HIS CB   C N N 151 
HIS CG   C Y N 152 
HIS ND1  N Y N 153 
HIS CD2  C Y N 154 
HIS CE1  C Y N 155 
HIS NE2  N Y N 156 
HIS OXT  O N N 157 
HIS H    H N N 158 
HIS H2   H N N 159 
HIS HA   H N N 160 
HIS HB2  H N N 161 
HIS HB3  H N N 162 
HIS HD1  H N N 163 
HIS HD2  H N N 164 
HIS HE1  H N N 165 
HIS HE2  H N N 166 
HIS HXT  H N N 167 
HOH O    O N N 168 
HOH H1   H N N 169 
HOH H2   H N N 170 
ILE N    N N N 171 
ILE CA   C N S 172 
ILE C    C N N 173 
ILE O    O N N 174 
ILE CB   C N S 175 
ILE CG1  C N N 176 
ILE CG2  C N N 177 
ILE CD1  C N N 178 
ILE OXT  O N N 179 
ILE H    H N N 180 
ILE H2   H N N 181 
ILE HA   H N N 182 
ILE HB   H N N 183 
ILE HG12 H N N 184 
ILE HG13 H N N 185 
ILE HG21 H N N 186 
ILE HG22 H N N 187 
ILE HG23 H N N 188 
ILE HD11 H N N 189 
ILE HD12 H N N 190 
ILE HD13 H N N 191 
ILE HXT  H N N 192 
LEU N    N N N 193 
LEU CA   C N S 194 
LEU C    C N N 195 
LEU O    O N N 196 
LEU CB   C N N 197 
LEU CG   C N N 198 
LEU CD1  C N N 199 
LEU CD2  C N N 200 
LEU OXT  O N N 201 
LEU H    H N N 202 
LEU H2   H N N 203 
LEU HA   H N N 204 
LEU HB2  H N N 205 
LEU HB3  H N N 206 
LEU HG   H N N 207 
LEU HD11 H N N 208 
LEU HD12 H N N 209 
LEU HD13 H N N 210 
LEU HD21 H N N 211 
LEU HD22 H N N 212 
LEU HD23 H N N 213 
LEU HXT  H N N 214 
LYS N    N N N 215 
LYS CA   C N S 216 
LYS C    C N N 217 
LYS O    O N N 218 
LYS CB   C N N 219 
LYS CG   C N N 220 
LYS CD   C N N 221 
LYS CE   C N N 222 
LYS NZ   N N N 223 
LYS OXT  O N N 224 
LYS H    H N N 225 
LYS H2   H N N 226 
LYS HA   H N N 227 
LYS HB2  H N N 228 
LYS HB3  H N N 229 
LYS HG2  H N N 230 
LYS HG3  H N N 231 
LYS HD2  H N N 232 
LYS HD3  H N N 233 
LYS HE2  H N N 234 
LYS HE3  H N N 235 
LYS HZ1  H N N 236 
LYS HZ2  H N N 237 
LYS HZ3  H N N 238 
LYS HXT  H N N 239 
MET N    N N N 240 
MET CA   C N S 241 
MET C    C N N 242 
MET O    O N N 243 
MET CB   C N N 244 
MET CG   C N N 245 
MET SD   S N N 246 
MET CE   C N N 247 
MET OXT  O N N 248 
MET H    H N N 249 
MET H2   H N N 250 
MET HA   H N N 251 
MET HB2  H N N 252 
MET HB3  H N N 253 
MET HG2  H N N 254 
MET HG3  H N N 255 
MET HE1  H N N 256 
MET HE2  H N N 257 
MET HE3  H N N 258 
MET HXT  H N N 259 
NAG C1   C N R 260 
NAG C2   C N R 261 
NAG C3   C N R 262 
NAG C4   C N S 263 
NAG C5   C N R 264 
NAG C6   C N N 265 
NAG C7   C N N 266 
NAG C8   C N N 267 
NAG N2   N N N 268 
NAG O1   O N N 269 
NAG O3   O N N 270 
NAG O4   O N N 271 
NAG O5   O N N 272 
NAG O6   O N N 273 
NAG O7   O N N 274 
NAG H1   H N N 275 
NAG H2   H N N 276 
NAG H3   H N N 277 
NAG H4   H N N 278 
NAG H5   H N N 279 
NAG H61  H N N 280 
NAG H62  H N N 281 
NAG H81  H N N 282 
NAG H82  H N N 283 
NAG H83  H N N 284 
NAG HN2  H N N 285 
NAG HO1  H N N 286 
NAG HO3  H N N 287 
NAG HO4  H N N 288 
NAG HO6  H N N 289 
PHE N    N N N 290 
PHE CA   C N S 291 
PHE C    C N N 292 
PHE O    O N N 293 
PHE CB   C N N 294 
PHE CG   C Y N 295 
PHE CD1  C Y N 296 
PHE CD2  C Y N 297 
PHE CE1  C Y N 298 
PHE CE2  C Y N 299 
PHE CZ   C Y N 300 
PHE OXT  O N N 301 
PHE H    H N N 302 
PHE H2   H N N 303 
PHE HA   H N N 304 
PHE HB2  H N N 305 
PHE HB3  H N N 306 
PHE HD1  H N N 307 
PHE HD2  H N N 308 
PHE HE1  H N N 309 
PHE HE2  H N N 310 
PHE HZ   H N N 311 
PHE HXT  H N N 312 
PRO N    N N N 313 
PRO CA   C N S 314 
PRO C    C N N 315 
PRO O    O N N 316 
PRO CB   C N N 317 
PRO CG   C N N 318 
PRO CD   C N N 319 
PRO OXT  O N N 320 
PRO H    H N N 321 
PRO HA   H N N 322 
PRO HB2  H N N 323 
PRO HB3  H N N 324 
PRO HG2  H N N 325 
PRO HG3  H N N 326 
PRO HD2  H N N 327 
PRO HD3  H N N 328 
PRO HXT  H N N 329 
SER N    N N N 330 
SER CA   C N S 331 
SER C    C N N 332 
SER O    O N N 333 
SER CB   C N N 334 
SER OG   O N N 335 
SER OXT  O N N 336 
SER H    H N N 337 
SER H2   H N N 338 
SER HA   H N N 339 
SER HB2  H N N 340 
SER HB3  H N N 341 
SER HG   H N N 342 
SER HXT  H N N 343 
THR N    N N N 344 
THR CA   C N S 345 
THR C    C N N 346 
THR O    O N N 347 
THR CB   C N R 348 
THR OG1  O N N 349 
THR CG2  C N N 350 
THR OXT  O N N 351 
THR H    H N N 352 
THR H2   H N N 353 
THR HA   H N N 354 
THR HB   H N N 355 
THR HG1  H N N 356 
THR HG21 H N N 357 
THR HG22 H N N 358 
THR HG23 H N N 359 
THR HXT  H N N 360 
TRP N    N N N 361 
TRP CA   C N S 362 
TRP C    C N N 363 
TRP O    O N N 364 
TRP CB   C N N 365 
TRP CG   C Y N 366 
TRP CD1  C Y N 367 
TRP CD2  C Y N 368 
TRP NE1  N Y N 369 
TRP CE2  C Y N 370 
TRP CE3  C Y N 371 
TRP CZ2  C Y N 372 
TRP CZ3  C Y N 373 
TRP CH2  C Y N 374 
TRP OXT  O N N 375 
TRP H    H N N 376 
TRP H2   H N N 377 
TRP HA   H N N 378 
TRP HB2  H N N 379 
TRP HB3  H N N 380 
TRP HD1  H N N 381 
TRP HE1  H N N 382 
TRP HE3  H N N 383 
TRP HZ2  H N N 384 
TRP HZ3  H N N 385 
TRP HH2  H N N 386 
TRP HXT  H N N 387 
TYR N    N N N 388 
TYR CA   C N S 389 
TYR C    C N N 390 
TYR O    O N N 391 
TYR CB   C N N 392 
TYR CG   C Y N 393 
TYR CD1  C Y N 394 
TYR CD2  C Y N 395 
TYR CE1  C Y N 396 
TYR CE2  C Y N 397 
TYR CZ   C Y N 398 
TYR OH   O N N 399 
TYR OXT  O N N 400 
TYR H    H N N 401 
TYR H2   H N N 402 
TYR HA   H N N 403 
TYR HB2  H N N 404 
TYR HB3  H N N 405 
TYR HD1  H N N 406 
TYR HD2  H N N 407 
TYR HE1  H N N 408 
TYR HE2  H N N 409 
TYR HH   H N N 410 
TYR HXT  H N N 411 
VAL N    N N N 412 
VAL CA   C N S 413 
VAL C    C N N 414 
VAL O    O N N 415 
VAL CB   C N N 416 
VAL CG1  C N N 417 
VAL CG2  C N N 418 
VAL OXT  O N N 419 
VAL H    H N N 420 
VAL H2   H N N 421 
VAL HA   H N N 422 
VAL HB   H N N 423 
VAL HG11 H N N 424 
VAL HG12 H N N 425 
VAL HG13 H N N 426 
VAL HG21 H N N 427 
VAL HG22 H N N 428 
VAL HG23 H N N 429 
VAL HXT  H N N 430 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
NAG C1  C2   sing N N 246 
NAG C1  O1   sing N N 247 
NAG C1  O5   sing N N 248 
NAG C1  H1   sing N N 249 
NAG C2  C3   sing N N 250 
NAG C2  N2   sing N N 251 
NAG C2  H2   sing N N 252 
NAG C3  C4   sing N N 253 
NAG C3  O3   sing N N 254 
NAG C3  H3   sing N N 255 
NAG C4  C5   sing N N 256 
NAG C4  O4   sing N N 257 
NAG C4  H4   sing N N 258 
NAG C5  C6   sing N N 259 
NAG C5  O5   sing N N 260 
NAG C5  H5   sing N N 261 
NAG C6  O6   sing N N 262 
NAG C6  H61  sing N N 263 
NAG C6  H62  sing N N 264 
NAG C7  C8   sing N N 265 
NAG C7  N2   sing N N 266 
NAG C7  O7   doub N N 267 
NAG C8  H81  sing N N 268 
NAG C8  H82  sing N N 269 
NAG C8  H83  sing N N 270 
NAG N2  HN2  sing N N 271 
NAG O1  HO1  sing N N 272 
NAG O3  HO3  sing N N 273 
NAG O4  HO4  sing N N 274 
NAG O6  HO6  sing N N 275 
PHE N   CA   sing N N 276 
PHE N   H    sing N N 277 
PHE N   H2   sing N N 278 
PHE CA  C    sing N N 279 
PHE CA  CB   sing N N 280 
PHE CA  HA   sing N N 281 
PHE C   O    doub N N 282 
PHE C   OXT  sing N N 283 
PHE CB  CG   sing N N 284 
PHE CB  HB2  sing N N 285 
PHE CB  HB3  sing N N 286 
PHE CG  CD1  doub Y N 287 
PHE CG  CD2  sing Y N 288 
PHE CD1 CE1  sing Y N 289 
PHE CD1 HD1  sing N N 290 
PHE CD2 CE2  doub Y N 291 
PHE CD2 HD2  sing N N 292 
PHE CE1 CZ   doub Y N 293 
PHE CE1 HE1  sing N N 294 
PHE CE2 CZ   sing Y N 295 
PHE CE2 HE2  sing N N 296 
PHE CZ  HZ   sing N N 297 
PHE OXT HXT  sing N N 298 
PRO N   CA   sing N N 299 
PRO N   CD   sing N N 300 
PRO N   H    sing N N 301 
PRO CA  C    sing N N 302 
PRO CA  CB   sing N N 303 
PRO CA  HA   sing N N 304 
PRO C   O    doub N N 305 
PRO C   OXT  sing N N 306 
PRO CB  CG   sing N N 307 
PRO CB  HB2  sing N N 308 
PRO CB  HB3  sing N N 309 
PRO CG  CD   sing N N 310 
PRO CG  HG2  sing N N 311 
PRO CG  HG3  sing N N 312 
PRO CD  HD2  sing N N 313 
PRO CD  HD3  sing N N 314 
PRO OXT HXT  sing N N 315 
SER N   CA   sing N N 316 
SER N   H    sing N N 317 
SER N   H2   sing N N 318 
SER CA  C    sing N N 319 
SER CA  CB   sing N N 320 
SER CA  HA   sing N N 321 
SER C   O    doub N N 322 
SER C   OXT  sing N N 323 
SER CB  OG   sing N N 324 
SER CB  HB2  sing N N 325 
SER CB  HB3  sing N N 326 
SER OG  HG   sing N N 327 
SER OXT HXT  sing N N 328 
THR N   CA   sing N N 329 
THR N   H    sing N N 330 
THR N   H2   sing N N 331 
THR CA  C    sing N N 332 
THR CA  CB   sing N N 333 
THR CA  HA   sing N N 334 
THR C   O    doub N N 335 
THR C   OXT  sing N N 336 
THR CB  OG1  sing N N 337 
THR CB  CG2  sing N N 338 
THR CB  HB   sing N N 339 
THR OG1 HG1  sing N N 340 
THR CG2 HG21 sing N N 341 
THR CG2 HG22 sing N N 342 
THR CG2 HG23 sing N N 343 
THR OXT HXT  sing N N 344 
TRP N   CA   sing N N 345 
TRP N   H    sing N N 346 
TRP N   H2   sing N N 347 
TRP CA  C    sing N N 348 
TRP CA  CB   sing N N 349 
TRP CA  HA   sing N N 350 
TRP C   O    doub N N 351 
TRP C   OXT  sing N N 352 
TRP CB  CG   sing N N 353 
TRP CB  HB2  sing N N 354 
TRP CB  HB3  sing N N 355 
TRP CG  CD1  doub Y N 356 
TRP CG  CD2  sing Y N 357 
TRP CD1 NE1  sing Y N 358 
TRP CD1 HD1  sing N N 359 
TRP CD2 CE2  doub Y N 360 
TRP CD2 CE3  sing Y N 361 
TRP NE1 CE2  sing Y N 362 
TRP NE1 HE1  sing N N 363 
TRP CE2 CZ2  sing Y N 364 
TRP CE3 CZ3  doub Y N 365 
TRP CE3 HE3  sing N N 366 
TRP CZ2 CH2  doub Y N 367 
TRP CZ2 HZ2  sing N N 368 
TRP CZ3 CH2  sing Y N 369 
TRP CZ3 HZ3  sing N N 370 
TRP CH2 HH2  sing N N 371 
TRP OXT HXT  sing N N 372 
TYR N   CA   sing N N 373 
TYR N   H    sing N N 374 
TYR N   H2   sing N N 375 
TYR CA  C    sing N N 376 
TYR CA  CB   sing N N 377 
TYR CA  HA   sing N N 378 
TYR C   O    doub N N 379 
TYR C   OXT  sing N N 380 
TYR CB  CG   sing N N 381 
TYR CB  HB2  sing N N 382 
TYR CB  HB3  sing N N 383 
TYR CG  CD1  doub Y N 384 
TYR CG  CD2  sing Y N 385 
TYR CD1 CE1  sing Y N 386 
TYR CD1 HD1  sing N N 387 
TYR CD2 CE2  doub Y N 388 
TYR CD2 HD2  sing N N 389 
TYR CE1 CZ   doub Y N 390 
TYR CE1 HE1  sing N N 391 
TYR CE2 CZ   sing Y N 392 
TYR CE2 HE2  sing N N 393 
TYR CZ  OH   sing N N 394 
TYR OH  HH   sing N N 395 
TYR OXT HXT  sing N N 396 
VAL N   CA   sing N N 397 
VAL N   H    sing N N 398 
VAL N   H2   sing N N 399 
VAL CA  C    sing N N 400 
VAL CA  CB   sing N N 401 
VAL CA  HA   sing N N 402 
VAL C   O    doub N N 403 
VAL C   OXT  sing N N 404 
VAL CB  CG1  sing N N 405 
VAL CB  CG2  sing N N 406 
VAL CB  HB   sing N N 407 
VAL CG1 HG11 sing N N 408 
VAL CG1 HG12 sing N N 409 
VAL CG1 HG13 sing N N 410 
VAL CG2 HG21 sing N N 411 
VAL CG2 HG22 sing N N 412 
VAL CG2 HG23 sing N N 413 
VAL OXT HXT  sing N N 414 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5k6i 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 41 3 2' 
_space_group.name_Hall        'P 4bd 2ab 3' 
_space_group.IT_number        213 
_space_group.crystal_system   cubic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W3F 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005946 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005946 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005946 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 7.96527 ?       ? ? 9.05267  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 30  ? 158.90700 332.23300 34.25200  1.000 51.11573  ? 26  GLN F N   1 
ATOM   2    C CA  . GLN A 1 30  ? 160.07100 333.04300 34.65600  1.000 68.14058  ? 26  GLN F CA  1 
ATOM   3    C C   . GLN A 1 30  ? 159.77100 334.53300 34.86800  1.000 65.58321  ? 26  GLN F C   1 
ATOM   4    O O   . GLN A 1 30  ? 159.15500 335.18200 34.01500  1.000 60.87612  ? 26  GLN F O   1 
ATOM   5    C CB  . GLN A 1 30  ? 161.19300 332.91800 33.63400  1.000 64.59416  ? 26  GLN F CB  1 
ATOM   6    C CG  . GLN A 1 30  ? 162.57200 333.14300 34.22400  1.000 56.01950  ? 26  GLN F CG  1 
ATOM   7    C CD  . GLN A 1 30  ? 163.20700 331.84700 34.65900  1.000 62.77688  ? 26  GLN F CD  1 
ATOM   8    O OE1 . GLN A 1 30  ? 162.81500 330.76200 34.19600  1.000 63.65479  ? 26  GLN F OE1 1 
ATOM   9    N NE2 . GLN A 1 30  ? 164.15400 331.93700 35.59900  1.000 59.50005  ? 26  GLN F NE2 1 
ATOM   10   N N   . ASN A 1 31  ? 160.24600 335.07500 35.99300  1.000 62.48300  ? 27  ASN F N   1 
ATOM   11   C CA  . ASN A 1 31  ? 159.99300 336.46600 36.31900  1.000 53.81427  ? 27  ASN F CA  1 
ATOM   12   C C   . ASN A 1 31  ? 161.12400 337.37200 35.81700  1.000 49.29643  ? 27  ASN F C   1 
ATOM   13   O O   . ASN A 1 31  ? 162.24500 337.32700 36.34000  1.000 46.49684  ? 27  ASN F O   1 
ATOM   14   C CB  . ASN A 1 31  ? 159.90200 336.51600 37.84600  1.000 63.13702  ? 27  ASN F CB  1 
ATOM   15   C CG  . ASN A 1 31  ? 158.63300 335.80800 38.39100  1.000 77.80844  ? 27  ASN F CG  1 
ATOM   16   O OD1 . ASN A 1 31  ? 158.72100 334.70900 38.97400  1.000 70.51193  ? 27  ASN F OD1 1 
ATOM   17   N ND2 . ASN A 1 31  ? 157.46400 336.41100 38.18000  1.000 77.96878  ? 27  ASN F ND2 1 
ATOM   18   N N   . ILE A 1 32  ? 160.78700 338.27700 34.89400  1.000 47.20618  ? 28  ILE F N   1 
ATOM   19   C CA  . ILE A 1 32  ? 161.69200 339.28800 34.33700  1.000 38.70579  ? 28  ILE F CA  1 
ATOM   20   C C   . ILE A 1 32  ? 161.73600 340.51000 35.25200  1.000 36.42081  ? 28  ILE F C   1 
ATOM   21   O O   . ILE A 1 32  ? 160.68600 340.99500 35.67200  1.000 39.17429  ? 28  ILE F O   1 
ATOM   22   C CB  . ILE A 1 32  ? 161.25200 339.69200 32.92400  1.000 41.33951  ? 28  ILE F CB  1 
ATOM   23   C CG1 . ILE A 1 32  ? 161.26400 338.49800 31.98900  1.000 45.06921  ? 28  ILE F CG1 1 
ATOM   24   C CG2 . ILE A 1 32  ? 162.19500 340.75100 32.36800  1.000 39.24568  ? 28  ILE F CG2 1 
ATOM   25   C CD1 . ILE A 1 32  ? 162.64400 337.97700 31.72400  1.000 43.27332  ? 28  ILE F CD1 1 
ATOM   26   N N   . THR A 1 33  ? 162.91000 340.95000 35.67600  1.000 36.52724  ? 29  THR F N   1 
ATOM   27   C CA  . THR A 1 33  ? 162.92500 342.16000 36.50500  1.000 35.09587  ? 29  THR F CA  1 
ATOM   28   C C   . THR A 1 33  ? 163.94000 343.17700 35.98600  1.000 32.93355  ? 29  THR F C   1 
ATOM   29   O O   . THR A 1 33  ? 164.79800 342.85800 35.16900  1.000 33.11489  ? 29  THR F O   1 
ATOM   30   C CB  . THR A 1 33  ? 163.17400 341.81800 37.99300  1.000 39.21233  ? 29  THR F CB  1 
ATOM   31   O OG1 . THR A 1 33  ? 164.39100 341.07100 38.14200  1.000 43.79294  ? 29  THR F OG1 1 
ATOM   32   C CG2 . THR A 1 33  ? 162.02300 341.01900 38.53900  1.000 42.19124  ? 29  THR F CG2 1 
ATOM   33   N N   . GLU A 1 34  ? 163.82200 344.42300 36.43400  1.000 32.89993  ? 30  GLU F N   1 
ATOM   34   C CA  . GLU A 1 34  ? 164.75200 345.48500 36.02700  1.000 30.71175  ? 30  GLU F CA  1 
ATOM   35   C C   . GLU A 1 34  ? 165.13300 346.37100 37.19100  1.000 32.39910  ? 30  GLU F C   1 
ATOM   36   O O   . GLU A 1 34  ? 164.32600 346.63900 38.07700  1.000 34.73745  ? 30  GLU F O   1 
ATOM   37   C CB  . GLU A 1 34  ? 164.25000 346.39900 34.93800  1.000 29.16077  ? 30  GLU F CB  1 
ATOM   38   C CG  . GLU A 1 34  ? 164.46400 345.92400 33.55800  1.000 32.57422  ? 30  GLU F CG  1 
ATOM   39   C CD  . GLU A 1 34  ? 164.67900 347.08300 32.61800  1.000 31.07117  ? 30  GLU F CD  1 
ATOM   40   O OE1 . GLU A 1 34  ? 165.04300 348.15000 33.10900  1.000 33.97411  ? 30  GLU F OE1 1 
ATOM   41   O OE2 . GLU A 1 34  ? 164.45800 346.94300 31.39900  1.000 32.53640  ? 30  GLU F OE2 1 
ATOM   42   N N   . GLU A 1 35  ? 166.31900 346.95500 37.07500  1.000 32.59873  ? 31  GLU F N   1 
ATOM   43   C CA  . GLU A 1 35  ? 166.83600 347.87600 38.07900  1.000 31.13513  ? 31  GLU F CA  1 
ATOM   44   C C   . GLU A 1 35  ? 167.53400 349.02500 37.38100  1.000 33.63577  ? 31  GLU F C   1 
ATOM   45   O O   . GLU A 1 35  ? 168.43600 348.78600 36.57100  1.000 32.57766  ? 31  GLU F O   1 
ATOM   46   C CB  . GLU A 1 35  ? 167.82000 347.19300 39.04400  1.000 36.51432  ? 31  GLU F CB  1 
ATOM   47   C CG  . GLU A 1 35  ? 167.21900 346.25500 40.08100  1.000 43.15412  ? 31  GLU F CG  1 
ATOM   48   C CD  . GLU A 1 35  ? 168.27200 345.52700 40.90800  1.000 48.21612  ? 31  GLU F CD  1 
ATOM   49   O OE1 . GLU A 1 35  ? 169.45800 345.92400 40.85500  1.000 44.37897  ? 31  GLU F OE1 1 
ATOM   50   O OE2 . GLU A 1 35  ? 167.90500 344.55000 41.60800  1.000 58.94783  ? 31  GLU F OE2 1 
ATOM   51   N N   . PHE A 1 36  ? 166.99900 350.23800 37.54000  1.000 34.62824  ? 32  PHE F N   1 
ATOM   52   C CA  . PHE A 1 36  ? 167.65100 351.43900 37.02500  1.000 30.99497  ? 32  PHE F CA  1 
ATOM   53   C C   . PHE A 1 36  ? 168.45500 352.08300 38.14700  1.000 34.67598  ? 32  PHE F C   1 
ATOM   54   O O   . PHE A 1 36  ? 167.91600 352.32600 39.23500  1.000 35.12342  ? 32  PHE F O   1 
ATOM   55   C CB  . PHE A 1 36  ? 166.64100 352.41600 36.44600  1.000 28.53195  ? 32  PHE F CB  1 
ATOM   56   C CG  . PHE A 1 36  ? 167.23200 353.74300 36.12200  1.000 27.78255  ? 32  PHE F CG  1 
ATOM   57   C CD1 . PHE A 1 36  ? 168.01200 353.92700 34.99200  1.000 30.44759  ? 32  PHE F CD1 1 
ATOM   58   C CD2 . PHE A 1 36  ? 166.95400 354.83500 36.93400  1.000 24.88958  ? 32  PHE F CD2 1 
ATOM   59   C CE1 . PHE A 1 36  ? 168.55300 355.17100 34.70500  1.000 29.02161  ? 32  PHE F CE1 1 
ATOM   60   C CE2 . PHE A 1 36  ? 167.48800 356.06600 36.65400  1.000 28.12680  ? 32  PHE F CE2 1 
ATOM   61   C CZ  . PHE A 1 36  ? 168.28900 356.24300 35.53500  1.000 29.36893  ? 32  PHE F CZ  1 
ATOM   62   N N   . TYR A 1 37  ? 169.72700 352.40400 37.87600  1.000 28.89981  ? 33  TYR F N   1 
ATOM   63   C CA  . TYR A 1 37  ? 170.59600 352.97700 38.89700  1.000 29.57375  ? 33  TYR F CA  1 
ATOM   64   C C   . TYR A 1 37  ? 170.72500 354.44400 38.50500  1.000 31.78783  ? 33  TYR F C   1 
ATOM   65   O O   . TYR A 1 37  ? 171.48900 354.79400 37.60400  1.000 32.92512  ? 33  TYR F O   1 
ATOM   66   C CB  . TYR A 1 37  ? 171.95700 352.27500 38.94500  1.000 33.17967  ? 33  TYR F CB  1 
ATOM   67   C CG  . TYR A 1 37  ? 171.77700 350.77700 39.03600  1.000 32.13647  ? 33  TYR F CG  1 
ATOM   68   C CD1 . TYR A 1 37  ? 171.44500 350.13000 40.21500  1.000 33.54763  ? 33  TYR F CD1 1 
ATOM   69   C CD2 . TYR A 1 37  ? 172.07500 349.99300 37.92600  1.000 30.97349  ? 33  TYR F CD2 1 
ATOM   70   C CE1 . TYR A 1 37  ? 171.27000 348.73500 40.23800  1.000 33.61420  ? 33  TYR F CE1 1 
ATOM   71   C CE2 . TYR A 1 37  ? 171.94100 348.61800 37.94700  1.000 32.17651  ? 33  TYR F CE2 1 
ATOM   72   C CZ  . TYR A 1 37  ? 171.53800 347.98900 39.10100  1.000 35.27618  ? 33  TYR F CZ  1 
ATOM   73   O OH  . TYR A 1 37  ? 171.39000 346.61500 39.07900  1.000 36.67118  ? 33  TYR F OH  1 
ATOM   74   N N   . GLN A 1 38  ? 170.04400 355.31400 39.22400  1.000 32.00189  ? 34  GLN F N   1 
ATOM   75   C CA  . GLN A 1 38  ? 170.11000 356.73600 38.91400  1.000 31.62896  ? 34  GLN F CA  1 
ATOM   76   C C   . GLN A 1 38  ? 171.52000 357.29500 39.01700  1.000 32.62361  ? 34  GLN F C   1 
ATOM   77   O O   . GLN A 1 38  ? 171.84900 358.26900 38.33200  1.000 34.69257  ? 34  GLN F O   1 
ATOM   78   C CB  . GLN A 1 38  ? 169.19400 357.48200 39.86900  1.000 33.29093  ? 34  GLN F CB  1 
ATOM   79   C CG  . GLN A 1 38  ? 169.20100 358.97100 39.73600  1.000 34.59059  ? 34  GLN F CG  1 
ATOM   80   C CD  . GLN A 1 38  ? 168.34200 359.62500 40.81000  1.000 38.59076  ? 34  GLN F CD  1 
ATOM   81   O OE1 . GLN A 1 38  ? 168.23300 359.12400 41.94000  1.000 35.96582  ? 34  GLN F OE1 1 
ATOM   82   N NE2 . GLN A 1 38  ? 167.76400 360.77400 40.47700  1.000 46.97807  ? 34  GLN F NE2 1 
ATOM   83   N N   . SER A 1 39  ? 172.36800 356.69700 39.84300  1.000 34.12327  ? 35  SER F N   1 
ATOM   84   C CA  . SER A 1 39  ? 173.70400 357.24900 40.04600  1.000 35.13441  ? 35  SER F CA  1 
ATOM   85   C C   . SER A 1 39  ? 174.61100 357.08700 38.83000  1.000 31.41390  ? 35  SER F C   1 
ATOM   86   O O   . SER A 1 39  ? 175.48200 357.93100 38.59200  1.000 30.62874  ? 35  SER F O   1 
ATOM   87   C CB  . SER A 1 39  ? 174.34400 356.63000 41.30700  1.000 34.53813  ? 35  SER F CB  1 
ATOM   88   O OG  . SER A 1 39  ? 174.50100 355.21800 41.24300  1.000 31.28773  ? 35  SER F OG  1 
ATOM   89   N N   . THR A 1 40  ? 174.44300 356.03300 38.05900  1.000 30.28992  ? 36  THR F N   1 
ATOM   90   C CA  . THR A 1 40  ? 175.35400 355.76500 36.96000  1.000 32.08050  ? 36  THR F CA  1 
ATOM   91   C C   . THR A 1 40  ? 174.67100 355.78900 35.60800  1.000 30.53612  ? 36  THR F C   1 
ATOM   92   O O   . THR A 1 40  ? 175.30300 355.43300 34.60000  1.000 29.27915  ? 36  THR F O   1 
ATOM   93   C CB  . THR A 1 40  ? 176.10900 354.43400 37.17700  1.000 32.02013  ? 36  THR F CB  1 
ATOM   94   O OG1 . THR A 1 40  ? 175.19900 353.34800 37.40400  1.000 32.47681  ? 36  THR F OG1 1 
ATOM   95   C CG2 . THR A 1 40  ? 177.01800 354.57100 38.38200  1.000 27.86376  ? 36  THR F CG2 1 
ATOM   96   N N   . CYS A 1 41  ? 173.38600 356.12700 35.56400  1.000 32.05763  ? 37  CYS F N   1 
ATOM   97   C CA  . CYS A 1 41  ? 172.65500 356.18700 34.30800  1.000 30.28619  ? 37  CYS F CA  1 
ATOM   98   C C   . CYS A 1 41  ? 172.72200 354.84900 33.57200  1.000 26.49909  ? 37  CYS F C   1 
ATOM   99   O O   . CYS A 1 41  ? 173.01200 354.78400 32.37800  1.000 23.13635  ? 37  CYS F O   1 
ATOM   100  C CB  . CYS A 1 41  ? 173.19900 357.32000 33.41600  1.000 24.48056  ? 37  CYS F CB  1 
ATOM   101  S SG  . CYS A 1 41  ? 172.13400 357.71900 31.97800  1.000 28.50626  ? 37  CYS F SG  1 
ATOM   102  N N   . SER A 1 42  ? 172.42300 353.77300 34.29400  1.000 26.78382  ? 38  SER F N   1 
ATOM   103  C CA  . SER A 1 42  ? 172.49500 352.43300 33.73100  1.000 27.49119  ? 38  SER F CA  1 
ATOM   104  C C   . SER A 1 42  ? 171.35000 351.61900 34.29500  1.000 25.35110  ? 38  SER F C   1 
ATOM   105  O O   . SER A 1 42  ? 170.74900 351.98300 35.29900  1.000 27.57051  ? 38  SER F O   1 
ATOM   106  C CB  . SER A 1 42  ? 173.82400 351.75600 34.03000  1.000 30.23272  ? 38  SER F CB  1 
ATOM   107  O OG  . SER A 1 42  ? 174.12600 351.84300 35.41200  1.000 31.93425  ? 38  SER F OG  1 
ATOM   108  N N   . ALA A 1 43  ? 170.95400 350.62100 33.54800  1.000 24.18400  ? 39  ALA F N   1 
ATOM   109  C CA  . ALA A 1 43  ? 169.88400 349.71500 33.93000  1.000 28.45365  ? 39  ALA F CA  1 
ATOM   110  C C   . ALA A 1 43  ? 170.30100 348.27100 33.66200  1.000 27.07590  ? 39  ALA F C   1 
ATOM   111  O O   . ALA A 1 43  ? 171.10000 348.00600 32.75300  1.000 25.71994  ? 39  ALA F O   1 
ATOM   112  C CB  . ALA A 1 43  ? 168.56600 350.05500 33.23000  1.000 28.26355  ? 39  ALA F CB  1 
ATOM   113  N N   . VAL A 1 44  ? 169.80500 347.34600 34.48400  1.000 24.95226  ? 40  VAL F N   1 
ATOM   114  C CA  . VAL A 1 44  ? 170.08600 345.91600 34.32500  1.000 24.28657  ? 40  VAL F CA  1 
ATOM   115  C C   . VAL A 1 44  ? 168.78800 345.13600 34.24500  1.000 25.34362  ? 40  VAL F C   1 
ATOM   116  O O   . VAL A 1 44  ? 167.92000 345.28200 35.11500  1.000 29.06474  ? 40  VAL F O   1 
ATOM   117  C CB  . VAL A 1 44  ? 170.96100 345.33100 35.44500  1.000 26.20056  ? 40  VAL F CB  1 
ATOM   118  C CG1 . VAL A 1 44  ? 171.15500 343.89200 35.17600  1.000 27.71799  ? 40  VAL F CG1 1 
ATOM   119  C CG2 . VAL A 1 44  ? 172.35600 345.94500 35.41000  1.000 24.67032  ? 40  VAL F CG2 1 
ATOM   120  N N   . SER A 1 45  ? 168.61100 344.40200 33.14700  1.000 23.31137  ? 41  SER F N   1 
ATOM   121  C CA  . SER A 1 45  ? 167.44000 343.55200 32.94400  1.000 25.33723  ? 41  SER F CA  1 
ATOM   122  C C   . SER A 1 45  ? 167.81200 342.11900 33.34800  1.000 30.23835  ? 41  SER F C   1 
ATOM   123  O O   . SER A 1 45  ? 168.67900 341.50300 32.71700  1.000 30.80927  ? 41  SER F O   1 
ATOM   124  C CB  . SER A 1 45  ? 167.00200 343.60500 31.48500  1.000 26.33691  ? 41  SER F CB  1 
ATOM   125  O OG  . SER A 1 45  ? 166.73300 344.93300 31.10800  1.000 27.47281  ? 41  SER F OG  1 
ATOM   126  N N   . LYS A 1 46  ? 167.24200 341.62500 34.44900  1.000 32.43419  ? 42  LYS F N   1 
ATOM   127  C CA  . LYS A 1 46  ? 167.51600 340.29400 34.98400  1.000 29.42415  ? 42  LYS F CA  1 
ATOM   128  C C   . LYS A 1 46  ? 166.37200 339.29700 34.72900  1.000 33.71963  ? 42  LYS F C   1 
ATOM   129  O O   . LYS A 1 46  ? 165.24400 339.65600 34.34700  1.000 34.56394  ? 42  LYS F O   1 
ATOM   130  C CB  . LYS A 1 46  ? 167.94300 340.39100 36.45300  1.000 29.89124  ? 42  LYS F CB  1 
ATOM   131  C CG  . LYS A 1 46  ? 167.51400 341.62200 37.16300  1.000 37.96704  ? 42  LYS F CG  1 
ATOM   132  C CD  . LYS A 1 46  ? 167.89200 341.59500 38.64900  1.000 48.75049  ? 42  LYS F CD  1 
ATOM   133  C CE  . LYS A 1 46  ? 169.40600 341.43700 38.79600  1.000 47.03358  ? 42  LYS F CE  1 
ATOM   134  N NZ  . LYS A 1 46  ? 169.89700 341.67300 40.18800  1.000 50.63932  ? 42  LYS F NZ  1 
ATOM   135  N N   . GLY A 1 47  ? 166.68500 338.01500 35.00400  1.000 34.87068  ? 43  GLY F N   1 
ATOM   136  C CA  . GLY A 1 47  ? 165.76400 336.88900 34.97200  1.000 30.23041  ? 43  GLY F CA  1 
ATOM   137  C C   . GLY A 1 47  ? 165.83300 336.01300 33.73500  1.000 33.18119  ? 43  GLY F C   1 
ATOM   138  O O   . GLY A 1 47  ? 165.06300 335.05700 33.62300  1.000 39.11311  ? 43  GLY F O   1 
ATOM   139  N N   . TYR A 1 48  ? 166.73700 336.29800 32.81500  1.000 34.31199  ? 44  TYR F N   1 
ATOM   140  C CA  . TYR A 1 48  ? 166.88000 335.56900 31.56600  1.000 32.70943  ? 44  TYR F CA  1 
ATOM   141  C C   . TYR A 1 48  ? 167.73700 334.33700 31.82400  1.000 31.46988  ? 44  TYR F C   1 
ATOM   142  O O   . TYR A 1 48  ? 168.51100 334.31900 32.78600  1.000 33.13958  ? 44  TYR F O   1 
ATOM   143  C CB  . TYR A 1 48  ? 167.53200 336.45500 30.50800  1.000 32.36971  ? 44  TYR F CB  1 
ATOM   144  C CG  . TYR A 1 48  ? 166.66700 337.61200 30.08600  1.000 31.50482  ? 44  TYR F CG  1 
ATOM   145  C CD1 . TYR A 1 48  ? 166.67800 338.76700 30.83800  1.000 30.96354  ? 44  TYR F CD1 1 
ATOM   146  C CD2 . TYR A 1 48  ? 165.85900 337.56700 28.95600  1.000 30.33825  ? 44  TYR F CD2 1 
ATOM   147  C CE1 . TYR A 1 48  ? 165.91400 339.85300 30.50100  1.000 30.82424  ? 44  TYR F CE1 1 
ATOM   148  C CE2 . TYR A 1 48  ? 165.10000 338.65400 28.59300  1.000 32.35766  ? 44  TYR F CE2 1 
ATOM   149  C CZ  . TYR A 1 48  ? 165.12300 339.80900 29.38200  1.000 34.53358  ? 44  TYR F CZ  1 
ATOM   150  O OH  . TYR A 1 48  ? 164.37200 340.94400 29.08700  1.000 39.90658  ? 44  TYR F OH  1 
ATOM   151  N N   . LEU A 1 49  ? 167.42100 333.24300 31.12000  1.000 32.02808  ? 45  LEU F N   1 
ATOM   152  C CA  . LEU A 1 49  ? 168.14800 331.96900 31.14100  1.000 29.49725  ? 45  LEU F CA  1 
ATOM   153  C C   . LEU A 1 49  ? 169.04600 331.81300 29.91100  1.000 29.95686  ? 45  LEU F C   1 
ATOM   154  O O   . LEU A 1 49  ? 168.66900 332.18600 28.79900  1.000 31.72528  ? 45  LEU F O   1 
ATOM   155  C CB  . LEU A 1 49  ? 167.14500 330.82100 31.17600  1.000 35.29142  ? 45  LEU F CB  1 
ATOM   156  C CG  . LEU A 1 49  ? 166.24400 330.77600 32.41800  1.000 37.79896  ? 45  LEU F CG  1 
ATOM   157  C CD1 . LEU A 1 49  ? 165.27700 329.64100 32.27300  1.000 38.32749  ? 45  LEU F CD1 1 
ATOM   158  C CD2 . LEU A 1 49  ? 167.04300 330.66700 33.71500  1.000 38.99443  ? 45  LEU F CD2 1 
ATOM   159  N N   . SER A 1 50  ? 170.18600 331.16000 30.07200  1.000 29.43190  ? 46  SER F N   1 
ATOM   160  C CA  . SER A 1 50  ? 171.12200 331.10500 28.95000  1.000 29.75782  ? 46  SER F CA  1 
ATOM   161  C C   . SER A 1 50  ? 170.96600 329.87500 28.04400  1.000 26.57318  ? 46  SER F C   1 
ATOM   162  O O   . SER A 1 50  ? 170.44800 328.83100 28.43700  1.000 27.97070  ? 46  SER F O   1 
ATOM   163  C CB  . SER A 1 50  ? 172.55000 331.12000 29.46000  1.000 28.52031  ? 46  SER F CB  1 
ATOM   164  O OG  . SER A 1 50  ? 172.84900 329.83100 29.91600  1.000 29.77136  ? 46  SER F OG  1 
ATOM   165  N N   . ALA A 1 51  ? 171.46600 330.01500 26.81200  1.000 25.33381  ? 47  ALA F N   1 
ATOM   166  C CA  . ALA A 1 51  ? 171.81400 328.86800 25.97500  1.000 23.07315  ? 47  ALA F CA  1 
ATOM   167  C C   . ALA A 1 51  ? 173.02000 329.29000 25.14700  1.000 25.02448  ? 47  ALA F C   1 
ATOM   168  O O   . ALA A 1 51  ? 172.87400 329.95700 24.12300  1.000 27.25960  ? 47  ALA F O   1 
ATOM   169  C CB  . ALA A 1 51  ? 170.65400 328.46800 25.07500  1.000 26.05936  ? 47  ALA F CB  1 
ATOM   170  N N   . LEU A 1 52  ? 174.20000 328.92400 25.61200  1.000 27.36324  ? 48  LEU F N   1 
ATOM   171  C CA  . LEU A 1 52  ? 175.44300 329.32600 24.96700  1.000 27.75955  ? 48  LEU F CA  1 
ATOM   172  C C   . LEU A 1 52  ? 175.96100 328.22500 24.05900  1.000 29.24740  ? 48  LEU F C   1 
ATOM   173  O O   . LEU A 1 52  ? 176.03100 327.06200 24.47900  1.000 28.72138  ? 48  LEU F O   1 
ATOM   174  C CB  . LEU A 1 52  ? 176.49400 329.74300 25.99600  1.000 27.07565  ? 48  LEU F CB  1 
ATOM   175  C CG  . LEU A 1 52  ? 175.96800 330.78700 26.98800  1.000 27.78293  ? 48  LEU F CG  1 
ATOM   176  C CD1 . LEU A 1 52  ? 177.10700 331.26100 27.85600  1.000 27.53099  ? 48  LEU F CD1 1 
ATOM   177  C CD2 . LEU A 1 52  ? 175.29000 331.98400 26.29900  1.000 26.08979  ? 48  LEU F CD2 1 
ATOM   178  N N   . ARG A 1 53  ? 176.32600 328.57200 22.82800  1.000 32.68988  ? 49  ARG F N   1 
ATOM   179  C CA  . ARG A 1 53  ? 176.89600 327.55300 21.94800  1.000 32.86567  ? 49  ARG F CA  1 
ATOM   180  C C   . ARG A 1 53  ? 178.35000 327.31700 22.30900  1.000 34.47250  ? 49  ARG F C   1 
ATOM   181  O O   . ARG A 1 53  ? 179.17100 328.24100 22.23700  1.000 35.04070  ? 49  ARG F O   1 
ATOM   182  C CB  . ARG A 1 53  ? 176.84400 327.97300 20.49100  1.000 31.43260  ? 49  ARG F CB  1 
ATOM   183  C CG  . ARG A 1 53  ? 176.84400 326.79900 19.56300  1.000 32.01866  ? 49  ARG F CG  1 
ATOM   184  C CD  . ARG A 1 53  ? 177.62000 327.11000 18.27900  1.000 35.25534  ? 49  ARG F CD  1 
ATOM   185  N NE  . ARG A 1 53  ? 178.85900 327.85400 18.47500  1.000 34.44599  ? 49  ARG F NE  1 
ATOM   186  C CZ  . ARG A 1 53  ? 180.05200 327.29000 18.64000  1.000 35.42809  ? 49  ARG F CZ  1 
ATOM   187  N NH1 . ARG A 1 53  ? 180.19500 325.97400 18.70700  1.000 35.11022  ? 49  ARG F NH1 1 
ATOM   188  N NH2 . ARG A 1 53  ? 181.13100 328.06500 18.73400  1.000 33.82579  ? 49  ARG F NH2 1 
ATOM   189  N N   . THR A 1 54  ? 178.67500 326.05700 22.60700  1.000 35.66862  ? 50  THR F N   1 
ATOM   190  C CA  . THR A 1 54  ? 180.02700 325.65000 22.97600  1.000 33.82596  ? 50  THR F CA  1 
ATOM   191  C C   . THR A 1 54  ? 180.58200 324.52700 22.13200  1.000 36.47967  ? 50  THR F C   1 
ATOM   192  O O   . THR A 1 54  ? 181.80900 324.36100 22.10800  1.000 40.57556  ? 50  THR F O   1 
ATOM   193  C CB  . THR A 1 54  ? 180.09000 325.21200 24.45100  1.000 34.36831  ? 50  THR F CB  1 
ATOM   194  O OG1 . THR A 1 54  ? 179.23000 324.08100 24.64800  1.000 28.14435  ? 50  THR F OG1 1 
ATOM   195  C CG2 . THR A 1 54  ? 179.73200 326.36700 25.41400  1.000 31.70690  ? 50  THR F CG2 1 
ATOM   196  N N   . GLY A 1 55  ? 179.75300 323.79400 21.37900  1.000 37.59969  ? 51  GLY F N   1 
ATOM   197  C CA  . GLY A 1 55  ? 180.27800 322.72400 20.56200  1.000 37.58358  ? 51  GLY F CA  1 
ATOM   198  C C   . GLY A 1 55  ? 179.55000 322.65200 19.23700  1.000 36.64710  ? 51  GLY F C   1 
ATOM   199  O O   . GLY A 1 55  ? 178.54600 323.31600 19.01900  1.000 37.86398  ? 51  GLY F O   1 
ATOM   200  N N   . TRP A 1 56  ? 180.04100 321.78600 18.37900  1.000 38.20018  ? 52  TRP F N   1 
ATOM   201  C CA  . TRP A 1 56  ? 179.45000 321.61100 17.06900  1.000 35.09319  ? 52  TRP F CA  1 
ATOM   202  C C   . TRP A 1 56  ? 179.12900 320.14800 16.84800  1.000 38.96966  ? 52  TRP F C   1 
ATOM   203  O O   . TRP A 1 56  ? 179.93100 319.27900 17.18100  1.000 43.93643  ? 52  TRP F O   1 
ATOM   204  C CB  . TRP A 1 56  ? 180.36300 322.10500 15.96100  1.000 35.74139  ? 52  TRP F CB  1 
ATOM   205  C CG  . TRP A 1 56  ? 180.63700 323.60500 15.91000  1.000 38.25201  ? 52  TRP F CG  1 
ATOM   206  C CD1 . TRP A 1 56  ? 181.80600 324.24600 16.19700  1.000 38.72283  ? 52  TRP F CD1 1 
ATOM   207  C CD2 . TRP A 1 56  ? 179.70900 324.63000 15.51400  1.000 36.25037  ? 52  TRP F CD2 1 
ATOM   208  N NE1 . TRP A 1 56  ? 181.67000 325.60400 15.98200  1.000 37.80267  ? 52  TRP F NE1 1 
ATOM   209  C CE2 . TRP A 1 56  ? 180.38900 325.86100 15.57700  1.000 34.92535  ? 52  TRP F CE2 1 
ATOM   210  C CE3 . TRP A 1 56  ? 178.36500 324.62000 15.11500  1.000 34.81473  ? 52  TRP F CE3 1 
ATOM   211  C CZ2 . TRP A 1 56  ? 179.77300 327.06700 15.26600  1.000 38.07772  ? 52  TRP F CZ2 1 
ATOM   212  C CZ3 . TRP A 1 56  ? 177.75200 325.82700 14.80400  1.000 34.69471  ? 52  TRP F CZ3 1 
ATOM   213  C CH2 . TRP A 1 56  ? 178.45600 327.03000 14.88100  1.000 35.82143  ? 52  TRP F CH2 1 
ATOM   214  N N   . TYR A 1 57  ? 178.00900 319.87300 16.20100  1.000 42.84989  ? 53  TYR F N   1 
ATOM   215  C CA  . TYR A 1 57  ? 177.70500 318.50700 15.80700  1.000 44.20227  ? 53  TYR F CA  1 
ATOM   216  C C   . TYR A 1 57  ? 177.64000 318.51100 14.29000  1.000 38.74202  ? 53  TYR F C   1 
ATOM   217  O O   . TYR A 1 57  ? 176.75900 319.14100 13.70500  1.000 37.22221  ? 53  TYR F O   1 
ATOM   218  C CB  . TYR A 1 57  ? 176.40400 317.99800 16.41500  1.000 44.45322  ? 53  TYR F CB  1 
ATOM   219  C CG  . TYR A 1 57  ? 176.07700 316.60200 15.90100  1.000 57.14094  ? 53  TYR F CG  1 
ATOM   220  C CD1 . TYR A 1 57  ? 176.68700 315.47700 16.48000  1.000 56.21169  ? 53  TYR F CD1 1 
ATOM   221  C CD2 . TYR A 1 57  ? 175.16800 316.39200 14.86400  1.000 55.89007  ? 53  TYR F CD2 1 
ATOM   222  C CE1 . TYR A 1 57  ? 176.40900 314.19000 16.04300  1.000 57.49987  ? 53  TYR F CE1 1 
ATOM   223  C CE2 . TYR A 1 57  ? 174.88200 315.09200 14.41900  1.000 57.88322  ? 53  TYR F CE2 1 
ATOM   224  C CZ  . TYR A 1 57  ? 175.50700 313.99800 15.01700  1.000 62.37389  ? 53  TYR F CZ  1 
ATOM   225  O OH  . TYR A 1 57  ? 175.24300 312.71000 14.60000  1.000 65.04836  ? 53  TYR F OH  1 
ATOM   226  N N   . THR A 1 58  ? 178.61500 317.87700 13.65500  1.000 41.91559  ? 54  THR F N   1 
ATOM   227  C CA  . THR A 1 58  ? 178.64300 317.87900 12.20800  1.000 41.66306  ? 54  THR F CA  1 
ATOM   228  C C   . THR A 1 58  ? 177.89200 316.65500 11.72800  1.000 45.80384  ? 54  THR F C   1 
ATOM   229  O O   . THR A 1 58  ? 177.95400 315.58300 12.33400  1.000 52.33581  ? 54  THR F O   1 
ATOM   230  C CB  . THR A 1 58  ? 180.06800 317.84300 11.70000  1.000 40.13700  ? 54  THR F CB  1 
ATOM   231  O OG1 . THR A 1 58  ? 180.66700 316.63700 12.17800  1.000 47.66329  ? 54  THR F OG1 1 
ATOM   232  C CG2 . THR A 1 58  ? 180.82600 319.02500 12.22400  1.000 38.58498  ? 54  THR F CG2 1 
ATOM   233  N N   . SER A 1 59  ? 177.30100 316.79000 10.55600  1.000 45.09469  ? 55  SER F N   1 
ATOM   234  C CA  . SER A 1 59  ? 176.52300 315.71900 9.97300   1.000 46.35489  ? 55  SER F CA  1 
ATOM   235  C C   . SER A 1 59  ? 176.67100 315.77400 8.47100   1.000 47.42637  ? 55  SER F C   1 
ATOM   236  O O   . SER A 1 59  ? 176.85300 316.86200 7.91500   1.000 44.06383  ? 55  SER F O   1 
ATOM   237  C CB  . SER A 1 59  ? 175.05600 315.90700 10.38500  1.000 45.18867  ? 55  SER F CB  1 
ATOM   238  O OG  . SER A 1 59  ? 174.22100 314.88700 9.91200   1.000 52.83650  ? 55  SER F OG  1 
ATOM   239  N N   . VAL A 1 60  ? 176.74000 314.60800 7.83200   1.000 46.33648  ? 56  VAL F N   1 
ATOM   240  C CA  . VAL A 1 60  ? 176.91000 314.55800 6.38500   1.000 42.07078  ? 56  VAL F CA  1 
ATOM   241  C C   . VAL A 1 60  ? 175.54200 314.41200 5.72200   1.000 41.58114  ? 56  VAL F C   1 
ATOM   242  O O   . VAL A 1 60  ? 174.70200 313.60500 6.15000   1.000 41.67123  ? 56  VAL F O   1 
ATOM   243  C CB  . VAL A 1 60  ? 177.89400 313.46300 5.95700   1.000 43.92965  ? 56  VAL F CB  1 
ATOM   244  C CG1 . VAL A 1 60  ? 177.95300 313.39800 4.44500   1.000 44.71831  ? 56  VAL F CG1 1 
ATOM   245  C CG2 . VAL A 1 60  ? 179.27700 313.79800 6.49900   1.000 45.36275  ? 56  VAL F CG2 1 
ATOM   246  N N   . ILE A 1 61  ? 175.28700 315.27300 4.74400   1.000 38.43439  ? 57  ILE F N   1 
ATOM   247  C CA  . ILE A 1 61  ? 174.07600 315.28300 3.94000   1.000 39.07980  ? 57  ILE F CA  1 
ATOM   248  C C   . ILE A 1 61  ? 174.44700 314.94200 2.50200   1.000 40.05357  ? 57  ILE F C   1 
ATOM   249  O O   . ILE A 1 61  ? 175.39600 315.52100 1.95400   1.000 37.90200  ? 57  ILE F O   1 
ATOM   250  C CB  . ILE A 1 61  ? 173.35500 316.63600 4.01100   1.000 38.34855  ? 57  ILE F CB  1 
ATOM   251  C CG1 . ILE A 1 61  ? 173.21000 317.11500 5.45200   1.000 38.51193  ? 57  ILE F CG1 1 
ATOM   252  C CG2 . ILE A 1 61  ? 172.02100 316.56700 3.34500   1.000 41.00477  ? 57  ILE F CG2 1 
ATOM   253  C CD1 . ILE A 1 61  ? 172.40100 316.17600 6.29400   1.000 39.46968  ? 57  ILE F CD1 1 
ATOM   254  N N   . THR A 1 62  ? 173.89600 313.83300 2.00100   1.000 43.68302  ? 58  THR F N   1 
ATOM   255  C CA  . THR A 1 62  ? 174.14900 313.34300 0.65600   1.000 45.40438  ? 58  THR F CA  1 
ATOM   256  C C   . THR A 1 62  ? 172.91100 313.46700 -0.23400  1.000 43.07389  ? 58  THR F C   1 
ATOM   257  O O   . THR A 1 62  ? 171.76000 313.35700 0.22400   1.000 42.84299  ? 58  THR F O   1 
ATOM   258  C CB  . THR A 1 62  ? 174.63200 311.88400 0.64800   1.000 45.59259  ? 58  THR F CB  1 
ATOM   259  O OG1 . THR A 1 62  ? 173.57200 310.99400 1.03600   1.000 48.43056  ? 58  THR F OG1 1 
ATOM   260  C CG2 . THR A 1 62  ? 175.83700 311.72100 1.57300   1.000 45.43528  ? 58  THR F CG2 1 
ATOM   261  N N   . ILE A 1 63  ? 173.17300 313.67900 -1.52000  1.000 43.47926  ? 59  ILE F N   1 
ATOM   262  C CA  . ILE A 1 63  ? 172.16200 313.64400 -2.57000  1.000 45.25516  ? 59  ILE F CA  1 
ATOM   263  C C   . ILE A 1 63  ? 172.76200 312.71500 -3.61500  1.000 45.97490  ? 59  ILE F C   1 
ATOM   264  O O   . ILE A 1 63  ? 173.81400 313.02200 -4.20000  1.000 44.63471  ? 59  ILE F O   1 
ATOM   265  C CB  . ILE A 1 63  ? 171.85000 315.02800 -3.17200  1.000 44.61454  ? 59  ILE F CB  1 
ATOM   266  C CG1 . ILE A 1 63  ? 171.11400 315.91200 -2.16800  1.000 45.01194  ? 59  ILE F CG1 1 
ATOM   267  C CG2 . ILE A 1 63  ? 171.04100 314.90100 -4.45300  1.000 40.75385  ? 59  ILE F CG2 1 
ATOM   268  C CD1 . ILE A 1 63  ? 170.72100 317.24300 -2.71000  1.000 39.52096  ? 59  ILE F CD1 1 
ATOM   269  N N   . GLU A 1 64  ? 172.13000 311.56200 -3.80300  1.000 51.43604  ? 60  GLU F N   1 
ATOM   270  C CA  . GLU A 1 64  ? 172.58800 310.53900 -4.74300  1.000 49.69608  ? 60  GLU F CA  1 
ATOM   271  C C   . GLU A 1 64  ? 172.25300 311.01900 -6.16000  1.000 48.17010  ? 60  GLU F C   1 
ATOM   272  O O   . GLU A 1 64  ? 171.08400 311.23700 -6.48300  1.000 48.75335  ? 60  GLU F O   1 
ATOM   273  C CB  . GLU A 1 64  ? 172.01400 309.18200 -4.34400  1.000 48.99284  ? 60  GLU F CB  1 
ATOM   274  C CG  . GLU A 1 64  ? 172.95500 308.05400 -4.73300  1.000 60.99525  ? 60  GLU F CG  1 
ATOM   275  C CD  . GLU A 1 64  ? 172.58500 306.72500 -4.08500  1.000 71.45762  ? 60  GLU F CD  1 
ATOM   276  O OE1 . GLU A 1 64  ? 171.47700 306.18600 -4.36700  1.000 63.73052  ? 60  GLU F OE1 1 
ATOM   277  O OE2 . GLU A 1 64  ? 173.41300 306.23900 -3.25900  1.000 69.59450  ? 60  GLU F OE2 1 
ATOM   278  N N   . LEU A 1 65  ? 173.27300 311.27300 -6.96900  1.000 44.04496  ? 61  LEU F N   1 
ATOM   279  C CA  . LEU A 1 65  ? 173.16400 311.81000 -8.32000  1.000 44.26344  ? 61  LEU F CA  1 
ATOM   280  C C   . LEU A 1 65  ? 173.35900 310.75400 -9.40700  1.000 48.83020  ? 61  LEU F C   1 
ATOM   281  O O   . LEU A 1 65  ? 173.74800 309.61800 -9.15000  1.000 52.90446  ? 61  LEU F O   1 
ATOM   282  C CB  . LEU A 1 65  ? 174.21000 312.90200 -8.52600  1.000 45.79021  ? 61  LEU F CB  1 
ATOM   283  C CG  . LEU A 1 65  ? 174.18800 314.22000 -7.76300  1.000 49.55989  ? 61  LEU F CG  1 
ATOM   284  C CD1 . LEU A 1 65  ? 175.31400 315.08200 -8.33300  1.000 46.23899  ? 61  LEU F CD1 1 
ATOM   285  C CD2 . LEU A 1 65  ? 172.83200 314.93100 -7.81300  1.000 43.08401  ? 61  LEU F CD2 1 
ATOM   286  N N   . SER A 1 66  ? 173.04600 311.14300 -10.64500 1.000 49.01126  ? 62  SER F N   1 
ATOM   287  C CA  . SER A 1 66  ? 173.15100 310.27500 -11.81400 1.000 52.56476  ? 62  SER F CA  1 
ATOM   288  C C   . SER A 1 66  ? 174.27200 310.72400 -12.73500 1.000 60.29205  ? 62  SER F C   1 
ATOM   289  O O   . SER A 1 66  ? 174.23600 311.83900 -13.26200 1.000 57.33458  ? 62  SER F O   1 
ATOM   290  C CB  . SER A 1 66  ? 171.85700 310.25400 -12.62100 1.000 54.39378  ? 62  SER F CB  1 
ATOM   291  O OG  . SER A 1 66  ? 171.99600 309.33700 -13.69400 1.000 58.70893  ? 62  SER F OG  1 
ATOM   292  N N   . ASN A 1 67  ? 175.25100 309.83600 -12.94000 1.000 71.73729  ? 63  ASN F N   1 
ATOM   293  C CA  . ASN A 1 67  ? 176.38900 310.07500 -13.82900 1.000 74.44202  ? 63  ASN F CA  1 
ATOM   294  C C   . ASN A 1 67  ? 175.89900 309.79200 -15.23400 1.000 69.56764  ? 63  ASN F C   1 
ATOM   295  O O   . ASN A 1 67  ? 176.00300 308.67100 -15.73400 1.000 78.53465  ? 63  ASN F O   1 
ATOM   296  C CB  . ASN A 1 67  ? 177.56900 309.17000 -13.47100 1.000 82.35949  ? 63  ASN F CB  1 
ATOM   297  C CG  . ASN A 1 67  ? 178.62600 309.86700 -12.59300 1.000 91.58133  ? 63  ASN F CG  1 
ATOM   298  O OD1 . ASN A 1 67  ? 178.82900 311.09000 -12.66800 1.000 95.54263  ? 63  ASN F OD1 1 
ATOM   299  N ND2 . ASN A 1 67  ? 179.29100 309.07800 -11.74000 1.000 84.63133  ? 63  ASN F ND2 1 
ATOM   300  N N   . ILE A 1 68  ? 175.41100 310.81600 -15.91200 1.000 67.57410  ? 64  ILE F N   1 
ATOM   301  C CA  . ILE A 1 68  ? 174.92700 310.59900 -17.26100 1.000 72.21173  ? 64  ILE F CA  1 
ATOM   302  C C   . ILE A 1 68  ? 175.58900 311.63200 -18.13500 1.000 76.80998  ? 64  ILE F C   1 
ATOM   303  O O   . ILE A 1 68  ? 175.93300 312.73300 -17.69600 1.000 76.31635  ? 64  ILE F O   1 
ATOM   304  C CB  . ILE A 1 68  ? 173.39300 310.71100 -17.45500 1.000 67.69354  ? 64  ILE F CB  1 
ATOM   305  C CG1 . ILE A 1 68  ? 172.87100 312.07900 -17.06700 1.000 63.87926  ? 64  ILE F CG1 1 
ATOM   306  C CG2 . ILE A 1 68  ? 172.67600 309.71400 -16.57300 1.000 68.45644  ? 64  ILE F CG2 1 
ATOM   307  C CD1 . ILE A 1 68  ? 171.40800 312.04000 -16.81200 1.000 57.37858  ? 64  ILE F CD1 1 
ATOM   308  N N   . LYS A 1 69  ? 175.71600 311.28100 -19.39400 1.000 81.10726  ? 65  LYS F N   1 
ATOM   309  C CA  . LYS A 1 69  ? 176.21100 312.18600 -20.40700 1.000 92.38750  ? 65  LYS F CA  1 
ATOM   310  C C   . LYS A 1 69  ? 175.05400 312.43700 -21.34700 1.000 92.56757  ? 65  LYS F C   1 
ATOM   311  O O   . LYS A 1 69  ? 174.08200 311.68300 -21.35500 1.000 92.45522  ? 65  LYS F O   1 
ATOM   312  C CB  . LYS A 1 69  ? 177.41100 311.57200 -21.15600 1.000 98.36995  ? 65  LYS F CB  1 
ATOM   313  C CG  . LYS A 1 69  ? 178.66700 311.25800 -20.22600 1.000 97.49615  ? 65  LYS F CG  1 
ATOM   314  C CD  . LYS A 1 69  ? 179.42500 309.94900 -20.57100 1.000 96.97698  ? 65  LYS F CD  1 
ATOM   315  C CE  . LYS A 1 69  ? 178.61800 308.67600 -20.43500 1.000 94.90685  ? 65  LYS F CE  1 
ATOM   316  N NZ  . LYS A 1 69  ? 178.14900 308.33500 -19.07400 1.000 89.00019  ? 65  LYS F NZ  1 
ATOM   317  N N   . GLU A 1 70  ? 175.16600 313.49000 -22.14600 1.000 94.45109  ? 66  GLU F N   1 
ATOM   318  C CA  . GLU A 1 70  ? 174.03600 313.85100 -22.98600 1.000 99.88135  ? 66  GLU F CA  1 
ATOM   319  C C   . GLU A 1 70  ? 173.77700 312.72700 -23.97100 1.000 102.37551 ? 66  GLU F C   1 
ATOM   320  O O   . GLU A 1 70  ? 174.70800 312.12400 -24.51900 1.000 99.51116  ? 66  GLU F O   1 
ATOM   321  C CB  . GLU A 1 70  ? 174.22200 315.17600 -23.74300 1.000 100.72839 ? 66  GLU F CB  1 
ATOM   322  C CG  . GLU A 1 70  ? 172.83000 315.74400 -24.17400 1.000 97.21064  ? 66  GLU F CG  1 
ATOM   323  C CD  . GLU A 1 70  ? 172.85200 317.14400 -24.78900 1.000 98.20851  ? 66  GLU F CD  1 
ATOM   324  O OE1 . GLU A 1 70  ? 172.77500 318.13400 -24.02200 1.000 93.41802  ? 66  GLU F OE1 1 
ATOM   325  O OE2 . GLU A 1 70  ? 172.89200 317.25000 -26.03800 1.000 90.05998  ? 66  GLU F OE2 1 
ATOM   326  N N   . ASN A 1 71  ? 172.50200 312.43600 -24.18300 1.000 98.75913  ? 67  ASN F N   1 
ATOM   327  C CA  . ASN A 1 71  ? 172.13300 311.41000 -25.13200 1.000 98.89535  ? 67  ASN F CA  1 
ATOM   328  C C   . ASN A 1 71  ? 171.16100 312.06000 -26.09000 1.000 96.47917  ? 67  ASN F C   1 
ATOM   329  O O   . ASN A 1 71  ? 170.24900 312.79300 -25.69500 1.000 92.41177  ? 67  ASN F O   1 
ATOM   330  C CB  . ASN A 1 71  ? 171.50200 310.19100 -24.44500 1.000 95.32410  ? 67  ASN F CB  1 
ATOM   331  C CG  . ASN A 1 71  ? 172.49300 309.42700 -23.56800 1.000 95.36034  ? 67  ASN F CG  1 
ATOM   332  O OD1 . ASN A 1 71  ? 172.12500 308.46300 -22.89900 1.000 95.22107  ? 67  ASN F OD1 1 
ATOM   333  N ND2 . ASN A 1 71  ? 173.75600 309.84500 -23.58300 1.000 93.62690  ? 67  ASN F ND2 1 
ATOM   334  N N   . LYS A 1 72  ? 171.38600 311.75700 -27.35600 1.000 102.15576 ? 68  LYS F N   1 
ATOM   335  C CA  . LYS A 1 72  ? 170.62600 312.28700 -28.46700 1.000 103.97214 ? 68  LYS F CA  1 
ATOM   336  C C   . LYS A 1 72  ? 169.89100 311.17700 -29.19100 1.000 104.12904 ? 68  LYS F C   1 
ATOM   337  O O   . LYS A 1 72  ? 170.46400 310.12300 -29.49900 1.000 97.41965  ? 68  LYS F O   1 
ATOM   338  C CB  . LYS A 1 72  ? 171.54300 313.06000 -29.44700 1.000 100.11814 ? 68  LYS F CB  1 
ATOM   339  C CG  . LYS A 1 72  ? 170.82500 313.79200 -30.60600 1.000 94.94409  ? 68  LYS F CG  1 
ATOM   340  C CD  . LYS A 1 72  ? 171.77900 314.14500 -31.76600 1.000 89.33755  ? 68  LYS F CD  1 
ATOM   341  C CE  . LYS A 1 72  ? 171.07400 314.05400 -33.13100 1.000 79.80015  ? 68  LYS F CE  1 
ATOM   342  N NZ  . LYS A 1 72  ? 171.95000 314.43800 -34.27300 1.000 63.44469  ? 68  LYS F NZ  1 
ATOM   343  N N   . CYS A 1 73  ? 168.59700 311.37800 -29.32500 1.000 107.07104 ? 69  CYS F N   1 
ATOM   344  C CA  . CYS A 1 73  ? 167.71800 310.52900 -30.09600 1.000 108.83483 ? 69  CYS F CA  1 
ATOM   345  C C   . CYS A 1 73  ? 166.91400 311.53000 -30.91800 1.000 107.11564 ? 69  CYS F C   1 
ATOM   346  O O   . CYS A 1 73  ? 166.60300 312.62500 -30.42800 1.000 99.09111  ? 69  CYS F O   1 
ATOM   347  C CB  . CYS A 1 73  ? 166.87500 309.62900 -29.18400 1.000 105.38177 ? 69  CYS F CB  1 
ATOM   348  S SG  . CYS A 1 73  ? 166.28000 310.45000 -27.68500 1.000 113.50255 ? 69  CYS F SG  1 
ATOM   349  N N   . ASN A 1 74  ? 166.60200 311.18300 -32.17400 1.000 108.94791 ? 70  ASN F N   1 
ATOM   350  C CA  . ASN A 1 74  ? 165.77900 312.09300 -32.96800 1.000 109.23597 ? 70  ASN F CA  1 
ATOM   351  C C   . ASN A 1 74  ? 164.46200 312.32200 -32.22200 1.000 102.65395 ? 70  ASN F C   1 
ATOM   352  O O   . ASN A 1 74  ? 163.58100 311.45100 -32.16300 1.000 97.43749  ? 70  ASN F O   1 
ATOM   353  C CB  . ASN A 1 74  ? 165.62700 311.53100 -34.39500 1.000 107.62650 ? 70  ASN F CB  1 
ATOM   354  C CG  . ASN A 1 74  ? 166.96800 311.01200 -34.97500 1.000 104.76726 ? 70  ASN F CG  1 
ATOM   355  O OD1 . ASN A 1 74  ? 166.99600 310.05600 -35.76100 1.000 91.52222  ? 70  ASN F OD1 1 
ATOM   356  N ND2 . ASN A 1 74  ? 168.07900 311.64600 -34.57200 1.000 106.12883 ? 70  ASN F ND2 1 
ATOM   357  N N   . GLY A 1 75  ? 164.34500 313.51200 -31.65600 1.000 90.65716  ? 71  GLY F N   1 
ATOM   358  C CA  . GLY A 1 75  ? 163.16600 313.89200 -30.89500 1.000 78.59624  ? 71  GLY F CA  1 
ATOM   359  C C   . GLY A 1 75  ? 162.58700 315.26000 -31.16800 1.000 65.58982  ? 71  GLY F C   1 
ATOM   360  O O   . GLY A 1 75  ? 163.31600 316.23600 -31.31400 1.000 65.99671  ? 71  GLY F O   1 
ATOM   361  N N   . THR A 1 76  ? 161.27000 315.32600 -31.23200 1.000 57.02684  ? 72  THR F N   1 
ATOM   362  C CA  . THR A 1 76  ? 160.63000 316.61000 -31.47600 1.000 50.72033  ? 72  THR F CA  1 
ATOM   363  C C   . THR A 1 76  ? 159.36700 316.72000 -30.65600 1.000 47.36837  ? 72  THR F C   1 
ATOM   364  O O   . THR A 1 76  ? 158.80200 317.81400 -30.57900 1.000 46.66806  ? 72  THR F O   1 
ATOM   365  C CB  . THR A 1 76  ? 160.32200 316.84600 -32.95900 1.000 53.73617  ? 72  THR F CB  1 
ATOM   366  O OG1 . THR A 1 76  ? 161.56000 316.99400 -33.65300 1.000 59.44446  ? 72  THR F OG1 1 
ATOM   367  C CG2 . THR A 1 76  ? 159.45200 318.10600 -33.17800 1.000 46.93812  ? 72  THR F CG2 1 
ATOM   368  N N   . ASP A 1 77  ? 158.93800 315.62800 -30.01400 1.000 43.08590  ? 73  ASP F N   1 
ATOM   369  C CA  . ASP A 1 77  ? 157.68700 315.62900 -29.20400 1.000 41.47461  ? 73  ASP F CA  1 
ATOM   370  C C   . ASP A 1 77  ? 157.80300 316.70000 -28.12700 1.000 42.29170  ? 73  ASP F C   1 
ATOM   371  O O   . ASP A 1 77  ? 158.89300 316.83500 -27.57100 1.000 45.60850  ? 73  ASP F O   1 
ATOM   372  C CB  . ASP A 1 77  ? 157.36300 314.24900 -28.62900 1.000 39.30872  ? 73  ASP F CB  1 
ATOM   373  C CG  . ASP A 1 77  ? 156.25400 314.25000 -27.59600 1.000 45.69259  ? 73  ASP F CG  1 
ATOM   374  O OD1 . ASP A 1 77  ? 155.15600 314.73700 -27.90600 1.000 51.43422  ? 73  ASP F OD1 1 
ATOM   375  O OD2 . ASP A 1 77  ? 156.50400 313.77200 -26.49200 1.000 51.77905  ? 73  ASP F OD2 1 
ATOM   376  N N   . ALA A 1 78  ? 156.71000 317.40000 -27.81500 1.000 37.70142  ? 74  ALA F N   1 
ATOM   377  C CA  . ALA A 1 78  ? 156.89400 318.49700 -26.87700 1.000 35.68673  ? 74  ALA F CA  1 
ATOM   378  C C   . ALA A 1 78  ? 157.30400 317.98800 -25.49000 1.000 40.55683  ? 74  ALA F C   1 
ATOM   379  O O   . ALA A 1 78  ? 158.03600 318.67500 -24.75300 1.000 43.10937  ? 74  ALA F O   1 
ATOM   380  C CB  . ALA A 1 78  ? 155.61100 319.31500 -26.79000 1.000 38.63313  ? 74  ALA F CB  1 
ATOM   381  N N   . LYS A 1 79  ? 156.85100 316.77500 -25.12900 1.000 38.29601  ? 75  LYS F N   1 
ATOM   382  C CA  . LYS A 1 79  ? 157.16300 316.21400 -23.81800 1.000 37.44449  ? 75  LYS F CA  1 
ATOM   383  C C   . LYS A 1 79  ? 158.62100 315.81100 -23.72700 1.000 39.16136  ? 75  LYS F C   1 
ATOM   384  O O   . LYS A 1 79  ? 159.29200 316.07000 -22.71300 1.000 40.70249  ? 75  LYS F O   1 
ATOM   385  C CB  . LYS A 1 79  ? 156.23300 315.04600 -23.47300 1.000 38.64757  ? 75  LYS F CB  1 
ATOM   386  C CG  . LYS A 1 79  ? 154.85700 315.48900 -22.96200 1.000 37.07785  ? 75  LYS F CG  1 
ATOM   387  C CD  . LYS A 1 79  ? 153.99000 314.28700 -22.55400 1.000 37.99281  ? 75  LYS F CD  1 
ATOM   388  C CE  . LYS A 1 79  ? 152.86800 314.04400 -23.56600 1.000 38.42876  ? 75  LYS F CE  1 
ATOM   389  N NZ  . LYS A 1 79  ? 153.40600 313.81200 -24.94200 1.000 39.43125  ? 75  LYS F NZ  1 
ATOM   390  N N   . VAL A 1 80  ? 159.15100 315.29900 -24.84100 1.000 37.07050  ? 76  VAL F N   1 
ATOM   391  C CA  . VAL A 1 80  ? 160.55500 314.92800 -24.89300 1.000 37.62354  ? 76  VAL F CA  1 
ATOM   392  C C   . VAL A 1 80  ? 161.39900 316.17500 -24.78000 1.000 39.24176  ? 76  VAL F C   1 
ATOM   393  O O   . VAL A 1 80  ? 162.41200 316.19900 -24.06700 1.000 40.57632  ? 76  VAL F O   1 
ATOM   394  C CB  . VAL A 1 80  ? 160.85400 314.13700 -26.17400 1.000 41.15738  ? 76  VAL F CB  1 
ATOM   395  C CG1 . VAL A 1 80  ? 162.34400 313.91600 -26.36000 1.000 39.47043  ? 76  VAL F CG1 1 
ATOM   396  C CG2 . VAL A 1 80  ? 160.14000 312.79400 -26.11300 1.000 42.35279  ? 76  VAL F CG2 1 
ATOM   397  N N   . LYS A 1 81  ? 160.96400 317.24900 -25.42900 1.000 39.10021  ? 77  LYS F N   1 
ATOM   398  C CA  . LYS A 1 81  ? 161.69400 318.50500 -25.32400 1.000 41.95200  ? 77  LYS F CA  1 
ATOM   399  C C   . LYS A 1 81  ? 161.73000 319.00800 -23.88400 1.000 41.08639  ? 77  LYS F C   1 
ATOM   400  O O   . LYS A 1 81  ? 162.77600 319.46300 -23.40600 1.000 43.38965  ? 77  LYS F O   1 
ATOM   401  C CB  . LYS A 1 81  ? 161.05600 319.53100 -26.26900 1.000 45.05691  ? 77  LYS F CB  1 
ATOM   402  C CG  . LYS A 1 81  ? 161.70800 320.90900 -26.36300 1.000 54.70557  ? 77  LYS F CG  1 
ATOM   403  C CD  . LYS A 1 81  ? 160.77300 321.82200 -27.12300 1.000 58.00426  ? 77  LYS F CD  1 
ATOM   404  C CE  . LYS A 1 81  ? 161.32700 323.22400 -27.32100 1.000 60.41601  ? 77  LYS F CE  1 
ATOM   405  N NZ  . LYS A 1 81  ? 160.93400 323.72500 -28.67000 1.000 69.61927  ? 77  LYS F NZ  1 
ATOM   406  N N   . LEU A 1 82  ? 160.60700 318.93200 -23.17700 1.000 39.08687  ? 78  LEU F N   1 
ATOM   407  C CA  . LEU A 1 82  ? 160.58600 319.43500 -21.80700 1.000 40.15598  ? 78  LEU F CA  1 
ATOM   408  C C   . LEU A 1 82  ? 161.52600 318.62700 -20.92300 1.000 37.56752  ? 78  LEU F C   1 
ATOM   409  O O   . LEU A 1 82  ? 162.24300 319.18500 -20.08000 1.000 41.27869  ? 78  LEU F O   1 
ATOM   410  C CB  . LEU A 1 82  ? 159.17200 319.39000 -21.23300 1.000 37.33516  ? 78  LEU F CB  1 
ATOM   411  C CG  . LEU A 1 82  ? 158.18800 320.40700 -21.81300 1.000 34.67505  ? 78  LEU F CG  1 
ATOM   412  C CD1 . LEU A 1 82  ? 156.78800 320.11000 -21.34100 1.000 34.26271  ? 78  LEU F CD1 1 
ATOM   413  C CD2 . LEU A 1 82  ? 158.56000 321.85700 -21.55800 1.000 46.69283  ? 78  LEU F CD2 1 
ATOM   414  N N   . ILE A 1 83  ? 161.54600 317.31200 -21.11700 1.000 34.04355  ? 79  ILE F N   1 
ATOM   415  C CA  . ILE A 1 83  ? 162.43000 316.46100 -20.33600 1.000 33.32682  ? 79  ILE F CA  1 
ATOM   416  C C   . ILE A 1 83  ? 163.88000 316.79800 -20.62300 1.000 38.13931  ? 79  ILE F C   1 
ATOM   417  O O   . ILE A 1 83  ? 164.70200 316.83800 -19.70700 1.000 41.82112  ? 79  ILE F O   1 
ATOM   418  C CB  . ILE A 1 83  ? 162.13700 314.97700 -20.59200 1.000 34.38501  ? 79  ILE F CB  1 
ATOM   419  C CG1 . ILE A 1 83  ? 160.93600 314.54800 -19.77600 1.000 32.76120  ? 79  ILE F CG1 1 
ATOM   420  C CG2 . ILE A 1 83  ? 163.29100 314.12900 -20.10600 1.000 29.63823  ? 79  ILE F CG2 1 
ATOM   421  C CD1 . ILE A 1 83  ? 161.14200 314.70200 -18.30500 1.000 34.80542  ? 79  ILE F CD1 1 
ATOM   422  N N   . LYS A 1 84  ? 164.25000 316.94900 -21.90200 1.000 40.30346  ? 80  LYS F N   1 
ATOM   423  C CA  . LYS A 1 84  ? 165.65200 317.28000 -22.18200 1.000 40.35824  ? 80  LYS F CA  1 
ATOM   424  C C   . LYS A 1 84  ? 166.02700 318.64900 -21.63000 1.000 44.58886  ? 80  LYS F C   1 
ATOM   425  O O   . LYS A 1 84  ? 167.15200 318.83600 -21.15400 1.000 44.95088  ? 80  LYS F O   1 
ATOM   426  C CB  . LYS A 1 84  ? 166.03100 317.21300 -23.67300 1.000 40.06839  ? 80  LYS F CB  1 
ATOM   427  C CG  . LYS A 1 84  ? 165.93300 315.84800 -24.37000 1.000 49.00000  ? 80  LYS F CG  1 
ATOM   428  C CD  . LYS A 1 84  ? 166.16800 315.98800 -25.89300 1.000 54.06430  ? 80  LYS F CD  1 
ATOM   429  C CE  . LYS A 1 84  ? 166.41200 314.62500 -26.56400 1.000 72.31939  ? 80  LYS F CE  1 
ATOM   430  N NZ  . LYS A 1 84  ? 166.72200 314.70300 -28.02900 1.000 77.71178  ? 80  LYS F NZ  1 
ATOM   431  N N   . GLN A 1 85  ? 165.08000 319.58400 -21.60200 1.000 44.10133  ? 81  GLN F N   1 
ATOM   432  C CA  . GLN A 1 85  ? 165.34500 320.88900 -21.00900 1.000 42.34323  ? 81  GLN F CA  1 
ATOM   433  C C   . GLN A 1 85  ? 165.64000 320.76500 -19.52100 1.000 42.85631  ? 81  GLN F C   1 
ATOM   434  O O   . GLN A 1 85  ? 166.63400 321.31600 -19.01600 1.000 43.72615  ? 81  GLN F O   1 
ATOM   435  C CB  . GLN A 1 85  ? 164.13000 321.78800 -21.23900 1.000 42.61966  ? 81  GLN F CB  1 
ATOM   436  C CG  . GLN A 1 85  ? 163.99000 322.38200 -22.64400 1.000 48.78955  ? 81  GLN F CG  1 
ATOM   437  C CD  . GLN A 1 85  ? 162.83800 323.39900 -22.74900 1.000 59.99360  ? 81  GLN F CD  1 
ATOM   438  O OE1 . GLN A 1 85  ? 162.24600 323.82100 -21.73900 1.000 59.48720  ? 81  GLN F OE1 1 
ATOM   439  N NE2 . GLN A 1 85  ? 162.54600 323.82200 -23.97600 1.000 61.43783  ? 81  GLN F NE2 1 
ATOM   440  N N   . GLU A 1 86  ? 164.78900 320.04700 -18.79700 1.000 41.69171  ? 82  GLU F N   1 
ATOM   441  C CA  . GLU A 1 86  ? 165.06200 319.86300 -17.38000 1.000 41.74678  ? 82  GLU F CA  1 
ATOM   442  C C   . GLU A 1 86  ? 166.34500 319.03800 -17.16900 1.000 40.65239  ? 82  GLU F C   1 
ATOM   443  O O   . GLU A 1 86  ? 167.07300 319.24600 -16.19200 1.000 40.65461  ? 82  GLU F O   1 
ATOM   444  C CB  . GLU A 1 86  ? 163.83700 319.21900 -16.73500 1.000 40.73158  ? 82  GLU F CB  1 
ATOM   445  C CG  . GLU A 1 86  ? 163.83600 319.14300 -15.22500 1.000 43.13676  ? 82  GLU F CG  1 
ATOM   446  C CD  . GLU A 1 86  ? 163.72600 320.56600 -14.61700 1.000 45.16304  ? 82  GLU F CD  1 
ATOM   447  O OE1 . GLU A 1 86  ? 163.24800 321.47000 -15.34700 1.000 45.20743  ? 82  GLU F OE1 1 
ATOM   448  O OE2 . GLU A 1 86  ? 164.05900 320.77600 -13.41400 1.000 44.63123  ? 82  GLU F OE2 1 
ATOM   449  N N   . LEU A 1 87  ? 166.67500 318.13100 -18.08300 1.000 39.18936  ? 83  LEU F N   1 
ATOM   450  C CA  . LEU A 1 87  ? 167.91500 317.38600 -17.91200 1.000 42.49870  ? 83  LEU F CA  1 
ATOM   451  C C   . LEU A 1 87  ? 169.13300 318.27600 -18.12300 1.000 45.79311  ? 83  LEU F C   1 
ATOM   452  O O   . LEU A 1 87  ? 170.17300 318.05700 -17.49300 1.000 45.16984  ? 83  LEU F O   1 
ATOM   453  C CB  . LEU A 1 87  ? 167.95700 316.19400 -18.85300 1.000 43.01578  ? 83  LEU F CB  1 
ATOM   454  C CG  . LEU A 1 87  ? 167.49300 314.90000 -18.20900 1.000 36.67910  ? 83  LEU F CG  1 
ATOM   455  C CD1 . LEU A 1 87  ? 167.19500 313.90200 -19.30900 1.000 36.16668  ? 83  LEU F CD1 1 
ATOM   456  C CD2 . LEU A 1 87  ? 168.56900 314.38600 -17.29600 1.000 38.28904  ? 83  LEU F CD2 1 
ATOM   457  N N   . ASP A 1 88  ? 169.04100 319.26900 -19.01400 1.000 49.09354  ? 84  ASP F N   1 
ATOM   458  C CA  . ASP A 1 88  ? 170.17400 320.18200 -19.15700 1.000 48.66200  ? 84  ASP F CA  1 
ATOM   459  C C   . ASP A 1 88  ? 170.29600 321.05200 -17.93700 1.000 44.78275  ? 84  ASP F C   1 
ATOM   460  O O   . ASP A 1 88  ? 171.40400 321.37500 -17.51100 1.000 47.37056  ? 84  ASP F O   1 
ATOM   461  C CB  . ASP A 1 88  ? 170.07300 321.11600 -20.37600 1.000 46.16828  ? 84  ASP F CB  1 
ATOM   462  C CG  . ASP A 1 88  ? 170.26800 320.40800 -21.70000 1.000 58.55103  ? 84  ASP F CG  1 
ATOM   463  O OD1 . ASP A 1 88  ? 170.84800 319.29200 -21.72600 1.000 64.33327  ? 84  ASP F OD1 1 
ATOM   464  O OD2 . ASP A 1 88  ? 169.87700 320.99800 -22.73200 1.000 60.35292  ? 84  ASP F OD2 1 
ATOM   465  N N   . LYS A 1 89  ? 169.17300 321.41600 -17.34300 1.000 43.71309  ? 85  LYS F N   1 
ATOM   466  C CA  . LYS A 1 89  ? 169.27800 322.16300 -16.10700 1.000 44.53803  ? 85  LYS F CA  1 
ATOM   467  C C   . LYS A 1 89  ? 169.91400 321.32900 -14.98700 1.000 44.35208  ? 85  LYS F C   1 
ATOM   468  O O   . LYS A 1 89  ? 170.73500 321.85500 -14.21000 1.000 44.90984  ? 85  LYS F O   1 
ATOM   469  C CB  . LYS A 1 89  ? 167.86100 322.62600 -15.71800 1.000 41.65450  ? 85  LYS F CB  1 
ATOM   470  C CG  . LYS A 1 89  ? 167.35600 323.79800 -16.58400 1.000 42.48407  ? 85  LYS F CG  1 
ATOM   471  C CD  . LYS A 1 89  ? 166.31600 324.69400 -15.91900 1.000 41.45651  ? 85  LYS F CD  1 
ATOM   472  C CE  . LYS A 1 89  ? 165.19200 323.91500 -15.26800 1.000 50.36686  ? 85  LYS F CE  1 
ATOM   473  N NZ  . LYS A 1 89  ? 164.14000 324.80200 -14.65100 1.000 50.08208  ? 85  LYS F NZ  1 
ATOM   474  N N   . TYR A 1 90  ? 169.68300 320.00600 -14.99300 1.000 41.90804  ? 86  TYR F N   1 
ATOM   475  C CA  . TYR A 1 90  ? 170.37900 319.11900 -14.06000 1.000 38.54459  ? 86  TYR F CA  1 
ATOM   476  C C   . TYR A 1 90  ? 171.87300 318.99300 -14.35900 1.000 42.19670  ? 86  TYR F C   1 
ATOM   477  O O   . TYR A 1 90  ? 172.69800 319.03100 -13.43700 1.000 39.65395  ? 86  TYR F O   1 
ATOM   478  C CB  . TYR A 1 90  ? 169.72400 317.73200 -14.14900 1.000 35.34880  ? 86  TYR F CB  1 
ATOM   479  C CG  . TYR A 1 90  ? 170.45800 316.61100 -13.44700 1.000 35.67616  ? 86  TYR F CG  1 
ATOM   480  C CD1 . TYR A 1 90  ? 170.26400 316.36100 -12.09500 1.000 36.82701  ? 86  TYR F CD1 1 
ATOM   481  C CD2 . TYR A 1 90  ? 171.43700 315.88200 -14.10900 1.000 39.91459  ? 86  TYR F CD2 1 
ATOM   482  C CE1 . TYR A 1 90  ? 170.95200 315.35400 -11.44400 1.000 36.45115  ? 86  TYR F CE1 1 
ATOM   483  C CE2 . TYR A 1 90  ? 172.14500 314.88300 -13.47000 1.000 39.00467  ? 86  TYR F CE2 1 
ATOM   484  C CZ  . TYR A 1 90  ? 171.89800 314.62500 -12.13700 1.000 39.22717  ? 86  TYR F CZ  1 
ATOM   485  O OH  . TYR A 1 90  ? 172.59100 313.62600 -11.50100 1.000 42.90490  ? 86  TYR F OH  1 
ATOM   486  N N   . LYS A 1 91  ? 172.25000 318.91100 -15.64100 1.000 45.15836  ? 87  LYS F N   1 
ATOM   487  C CA  . LYS A 1 91  ? 173.66900 318.74300 -15.94800 1.000 44.56243  ? 87  LYS F CA  1 
ATOM   488  C C   . LYS A 1 91  ? 174.45800 320.01600 -15.70800 1.000 43.81913  ? 87  LYS F C   1 
ATOM   489  O O   . LYS A 1 91  ? 175.59400 319.95300 -15.21700 1.000 42.45040  ? 87  LYS F O   1 
ATOM   490  C CB  . LYS A 1 91  ? 173.91500 318.12700 -17.33300 1.000 47.76011  ? 87  LYS F CB  1 
ATOM   491  C CG  . LYS A 1 91  ? 173.42300 316.67400 -17.32800 1.000 51.36422  ? 87  LYS F CG  1 
ATOM   492  C CD  . LYS A 1 91  ? 173.33000 315.90600 -18.65300 1.000 65.36934  ? 87  LYS F CD  1 
ATOM   493  C CE  . LYS A 1 91  ? 172.33200 316.43800 -19.65500 1.000 69.56898  ? 87  LYS F CE  1 
ATOM   494  N NZ  . LYS A 1 91  ? 172.88100 316.46500 -21.04800 1.000 73.67928  ? 87  LYS F NZ  1 
ATOM   495  N N   . ASN A 1 92  ? 173.87900 321.17500 -16.03500 1.000 44.82728  ? 88  ASN F N   1 
ATOM   496  C CA  A ASN A 1 92  ? 174.51700 322.42600 -15.64900 0.760 44.47082  ? 88  ASN F CA  1 
ATOM   497  C CA  B ASN A 1 92  ? 174.50500 322.43400 -15.64600 0.240 44.68391  ? 88  ASN F CA  1 
ATOM   498  C C   . ASN A 1 92  ? 174.61600 322.53700 -14.13100 1.000 43.84334  ? 88  ASN F C   1 
ATOM   499  O O   . ASN A 1 92  ? 175.62900 322.99900 -13.61300 1.000 44.83341  ? 88  ASN F O   1 
ATOM   500  C CB  A ASN A 1 92  ? 173.77300 323.62400 -16.24500 0.760 44.09585  ? 88  ASN F CB  1 
ATOM   501  C CB  B ASN A 1 92  ? 173.75300 323.64000 -16.24200 0.240 44.03968  ? 88  ASN F CB  1 
ATOM   502  C CG  A ASN A 1 92  ? 173.97700 323.75000 -17.74800 0.760 45.42051  ? 88  ASN F CG  1 
ATOM   503  C CG  B ASN A 1 92  ? 172.52400 324.08700 -15.42100 0.240 43.76328  ? 88  ASN F CG  1 
ATOM   504  O OD1 A ASN A 1 92  ? 174.92300 323.19900 -18.30700 0.760 46.96363  ? 88  ASN F OD1 1 
ATOM   505  O OD1 B ASN A 1 92  ? 172.50600 324.04400 -14.19100 0.240 42.58744  ? 88  ASN F OD1 1 
ATOM   506  N ND2 A ASN A 1 92  ? 173.09000 324.48300 -18.40600 0.760 45.60864  ? 88  ASN F ND2 1 
ATOM   507  N ND2 B ASN A 1 92  ? 171.51100 324.57900 -16.12600 0.240 42.58476  ? 88  ASN F ND2 1 
ATOM   508  N N   . ALA A 1 93  ? 173.59100 322.09400 -13.38900 1.000 40.61492  ? 89  ALA F N   1 
ATOM   509  C CA  . ALA A 1 93  ? 173.73400 322.15900 -11.93500 1.000 39.30984  ? 89  ALA F CA  1 
ATOM   510  C C   . ALA A 1 93  ? 174.88900 321.29000 -11.45200 1.000 40.43725  ? 89  ALA F C   1 
ATOM   511  O O   . ALA A 1 93  ? 175.67000 321.70100 -10.58600 1.000 45.52659  ? 89  ALA F O   1 
ATOM   512  C CB  . ALA A 1 93  ? 172.44500 321.74800 -11.23800 1.000 40.75298  ? 89  ALA F CB  1 
ATOM   513  N N   . VAL A 1 94  ? 175.08600 320.13500 -12.07100 1.000 41.91859  ? 90  VAL F N   1 
ATOM   514  C CA  . VAL A 1 94  ? 176.20100 319.29400 -11.65500 1.000 43.74475  ? 90  VAL F CA  1 
ATOM   515  C C   . VAL A 1 94  ? 177.53900 319.92000 -12.04500 1.000 43.87363  ? 90  VAL F C   1 
ATOM   516  O O   . VAL A 1 94  ? 178.47600 319.95600 -11.24100 1.000 46.23526  ? 90  VAL F O   1 
ATOM   517  C CB  . VAL A 1 94  ? 176.01900 317.87000 -12.21900 1.000 41.30898  ? 90  VAL F CB  1 
ATOM   518  C CG1 . VAL A 1 94  ? 177.21200 316.98400 -11.93900 1.000 35.57502  ? 90  VAL F CG1 1 
ATOM   519  C CG2 . VAL A 1 94  ? 174.84600 317.23500 -11.52100 1.000 38.48831  ? 90  VAL F CG2 1 
ATOM   520  N N   . THR A 1 95  ? 177.64500 320.48700 -13.23800 1.000 44.42372  ? 91  THR F N   1 
ATOM   521  C CA  . THR A 1 95  ? 178.93100 321.08100 -13.58100 1.000 44.17386  ? 91  THR F CA  1 
ATOM   522  C C   . THR A 1 95  ? 179.18700 322.33500 -12.74800 1.000 49.65741  ? 91  THR F C   1 
ATOM   523  O O   . THR A 1 95  ? 180.34600 322.65500 -12.44500 1.000 51.06392  ? 91  THR F O   1 
ATOM   524  C CB  . THR A 1 95  ? 179.01600 321.37300 -15.08500 1.000 47.54242  ? 91  THR F CB  1 
ATOM   525  O OG1 . THR A 1 95  ? 178.00200 322.31300 -15.46900 1.000 46.67509  ? 91  THR F OG1 1 
ATOM   526  C CG2 . THR A 1 95  ? 178.85800 320.07400 -15.90100 1.000 42.17221  ? 91  THR F CG2 1 
ATOM   527  N N   . ASP A 1 96  ? 178.12300 323.05300 -12.36600 1.000 50.00608  ? 92  ASP F N   1 
ATOM   528  C CA  . ASP A 1 96  ? 178.26900 324.22200 -11.50900 1.000 47.29755  ? 92  ASP F CA  1 
ATOM   529  C C   . ASP A 1 96  ? 178.75800 323.80500 -10.12600 1.000 48.17182  ? 92  ASP F C   1 
ATOM   530  O O   . ASP A 1 96  ? 179.62800 324.46400 -9.54000  1.000 50.80475  ? 92  ASP F O   1 
ATOM   531  C CB  . ASP A 1 96  ? 176.93800 324.98200 -11.38200 1.000 45.39976  ? 92  ASP F CB  1 
ATOM   532  C CG  . ASP A 1 96  ? 176.57800 325.78800 -12.64400 1.000 50.80016  ? 92  ASP F CG  1 
ATOM   533  O OD1 . ASP A 1 96  ? 177.48000 326.21100 -13.40300 1.000 52.70254  ? 92  ASP F OD1 1 
ATOM   534  O OD2 . ASP A 1 96  ? 175.36800 326.07800 -12.82700 1.000 52.89827  ? 92  ASP F OD2 1 
ATOM   535  N N   . LEU A 1 97  ? 178.24100 322.68400 -9.60400  1.000 43.88987  ? 93  LEU F N   1 
ATOM   536  C CA  . LEU A 1 97  ? 178.73200 322.18200 -8.32400  1.000 45.67972  ? 93  LEU F CA  1 
ATOM   537  C C   . LEU A 1 97  ? 180.15600 321.68000 -8.44100  1.000 49.14486  ? 93  LEU F C   1 
ATOM   538  O O   . LEU A 1 97  ? 180.91500 321.72500 -7.45900  1.000 51.09151  ? 93  LEU F O   1 
ATOM   539  C CB  . LEU A 1 97  ? 177.84400 321.06000 -7.81500  1.000 42.26010  ? 93  LEU F CB  1 
ATOM   540  C CG  . LEU A 1 97  ? 176.47900 321.47200 -7.30400  1.000 41.71342  ? 93  LEU F CG  1 
ATOM   541  C CD1 . LEU A 1 97  ? 175.73500 320.26000 -6.84000  1.000 41.95364  ? 93  LEU F CD1 1 
ATOM   542  C CD2 . LEU A 1 97  ? 176.69300 322.38000 -6.13200  1.000 41.16465  ? 93  LEU F CD2 1 
ATOM   543  N N   . GLN A 1 98  ? 180.56000 321.29400 -9.64800  1.000 47.56599  ? 94  GLN F N   1 
ATOM   544  C CA  . GLN A 1 98  ? 181.92100 320.81400 -9.81900  1.000 48.66211  ? 94  GLN F CA  1 
ATOM   545  C C   . GLN A 1 98  ? 182.88100 321.99100 -9.80300  1.000 52.75784  ? 94  GLN F C   1 
ATOM   546  O O   . GLN A 1 98  ? 183.91000 321.95400 -9.11000  1.000 56.52828  ? 94  GLN F O   1 
ATOM   547  C CB  . GLN A 1 98  ? 182.04900 320.00800 -11.11100 1.000 44.09722  ? 94  GLN F CB  1 
ATOM   548  C CG  . GLN A 1 98  ? 181.41700 318.61900 -11.02500 1.000 43.36166  ? 94  GLN F CG  1 
ATOM   549  C CD  . GLN A 1 98  ? 181.48500 317.83900 -12.33200 1.000 43.16317  ? 94  GLN F CD  1 
ATOM   550  O OE1 . GLN A 1 98  ? 181.58400 318.41800 -13.41800 1.000 45.27941  ? 94  GLN F OE1 1 
ATOM   551  N NE2 . GLN A 1 98  ? 181.43800 316.51400 -12.22700 1.000 42.63888  ? 94  GLN F NE2 1 
ATOM   552  N N   . LEU A 1 99  ? 182.53700 323.06800 -10.50500 1.000 52.47707  ? 95  LEU F N   1 
ATOM   553  C CA  . LEU A 1 99  ? 183.42200 324.21300 -10.43200 1.000 52.14636  ? 95  LEU F CA  1 
ATOM   554  C C   . LEU A 1 99  ? 183.34800 324.89800 -9.07100  1.000 55.50271  ? 95  LEU F C   1 
ATOM   555  O O   . LEU A 1 99  ? 184.27900 325.61800 -8.70300  1.000 63.53289  ? 95  LEU F O   1 
ATOM   556  C CB  . LEU A 1 99  ? 183.04200 325.17900 -11.55700 1.000 55.80746  ? 95  LEU F CB  1 
ATOM   557  C CG  . LEU A 1 99  ? 183.91600 326.38000 -11.92800 1.000 64.55399  ? 95  LEU F CG  1 
ATOM   558  C CD1 . LEU A 1 99  ? 185.09600 325.96700 -12.79800 1.000 62.92010  ? 95  LEU F CD1 1 
ATOM   559  C CD2 . LEU A 1 99  ? 183.05700 327.35000 -12.71000 1.000 55.89047  ? 95  LEU F CD2 1 
ATOM   560  N N   . LEU A 1 100 ? 182.28200 324.67100 -8.30500  1.000 56.24324  ? 96  LEU F N   1 
ATOM   561  C CA  . LEU A 1 100 ? 182.22800 325.17300 -6.93100  1.000 59.44054  ? 96  LEU F CA  1 
ATOM   562  C C   . LEU A 1 100 ? 183.10600 324.36800 -5.96800  1.000 58.36869  ? 96  LEU F C   1 
ATOM   563  O O   . LEU A 1 100 ? 183.67000 324.93300 -5.03100  1.000 61.29852  ? 96  LEU F O   1 
ATOM   564  C CB  . LEU A 1 100 ? 180.78000 325.19900 -6.42300  1.000 60.62782  ? 96  LEU F CB  1 
ATOM   565  C CG  . LEU A 1 100 ? 180.53100 325.68500 -4.98800  1.000 47.24530  ? 96  LEU F CG  1 
ATOM   566  C CD1 . LEU A 1 100 ? 180.92700 327.14900 -4.85300  1.000 48.24922  ? 96  LEU F CD1 1 
ATOM   567  C CD2 . LEU A 1 100 ? 179.08100 325.49400 -4.61000  1.000 45.53871  ? 96  LEU F CD2 1 
ATOM   568  N N   . MET A 1 101 ? 183.28100 323.06700 -6.20400  1.000 62.06724  ? 97  MET F N   1 
ATOM   569  C CA  . MET A 1 101 ? 184.08100 322.25500 -5.28600  1.000 65.73532  ? 97  MET F CA  1 
ATOM   570  C C   . MET A 1 101 ? 185.56800 322.25200 -5.62700  1.000 73.08068  ? 97  MET F C   1 
ATOM   571  O O   . MET A 1 101 ? 186.38500 321.91900 -4.75100  1.000 79.57570  ? 97  MET F O   1 
ATOM   572  C CB  . MET A 1 101 ? 183.55600 320.80400 -5.25100  1.000 61.06200  ? 97  MET F CB  1 
ATOM   573  C CG  . MET A 1 101 ? 184.59100 319.74700 -4.75800  1.000 65.70530  ? 97  MET F CG  1 
ATOM   574  S SD  . MET A 1 101 ? 184.71900 318.12200 -5.63600  1.000 68.64453  ? 97  MET F SD  1 
ATOM   575  C CE  . MET A 1 101 ? 185.14800 318.59600 -7.31600  1.000 61.19616  ? 97  MET F CE  1 
ATOM   576  N N   . GLN A 1 102 ? 185.94100 322.60800 -6.86600  1.000 71.57611  ? 98  GLN F N   1 
ATOM   577  C CA  . GLN A 1 102 ? 187.36100 322.81800 -7.16500  1.000 72.13431  ? 98  GLN F CA  1 
ATOM   578  C C   . GLN A 1 102 ? 187.94200 323.97500 -6.35200  1.000 78.78969  ? 98  GLN F C   1 
ATOM   579  O O   . GLN A 1 102 ? 189.04400 323.87200 -5.79400  1.000 80.45766  ? 98  GLN F O   1 
ATOM   580  C CB  . GLN A 1 102 ? 187.54400 323.12300 -8.65100  1.000 69.70921  ? 98  GLN F CB  1 
ATOM   581  C CG  . GLN A 1 102 ? 187.60200 321.93700 -9.57400  1.000 75.85345  ? 98  GLN F CG  1 
ATOM   582  C CD  . GLN A 1 102 ? 188.12100 322.34300 -10.94100 1.000 83.01728  ? 98  GLN F CD  1 
ATOM   583  O OE1 . GLN A 1 102 ? 188.38300 323.52900 -11.19000 1.000 79.06379  ? 98  GLN F OE1 1 
ATOM   584  N NE2 . GLN A 1 102 ? 188.25400 321.36900 -11.84300 1.000 82.19547  ? 98  GLN F NE2 1 
ATOM   585  N N   . SER A 1 103 ? 187.19900 325.07700 -6.26200  1.000 79.02249  ? 99  SER F N   1 
ATOM   586  C CA  . SER A 1 103 ? 187.58600 326.24200 -5.47900  1.000 76.10444  ? 99  SER F CA  1 
ATOM   587  C C   . SER A 1 103 ? 187.10000 326.01400 -4.05100  1.000 81.01812  ? 99  SER F C   1 
ATOM   588  O O   . SER A 1 103 ? 185.90100 326.13000 -3.77200  1.000 82.50733  ? 99  SER F O   1 
ATOM   589  C CB  . SER A 1 103 ? 186.96900 327.52200 -6.05900  1.000 72.22874  ? 99  SER F CB  1 
ATOM   590  O OG  . SER A 1 103 ? 187.41300 327.83200 -7.37600  1.000 65.14419  ? 99  SER F OG  1 
ATOM   591  N N   . THR A 1 104 ? 188.02100 325.74000 -3.13200  1.000 84.82486  ? 100 THR F N   1 
ATOM   592  C CA  . THR A 1 104 ? 187.60800 325.49400 -1.75500  1.000 94.68094  ? 100 THR F CA  1 
ATOM   593  C C   . THR A 1 104 ? 188.05600 326.73600 -0.98200  1.000 100.60690 ? 100 THR F C   1 
ATOM   594  O O   . THR A 1 104 ? 189.26200 327.03400 -0.89500  1.000 98.05063  ? 100 THR F O   1 
ATOM   595  C CB  . THR A 1 104 ? 188.20900 324.19000 -1.19900  1.000 95.52161  ? 100 THR F CB  1 
ATOM   596  O OG1 . THR A 1 104 ? 189.57300 324.05700 -1.62500  1.000 91.24205  ? 100 THR F OG1 1 
ATOM   597  C CG2 . THR A 1 104 ? 187.38400 322.95100 -1.68600  1.000 79.73132  ? 100 THR F CG2 1 
ATOM   598  N N   . PRO A 1 105 ? 187.08200 327.47600 -0.42000  1.000 99.46144  ? 101 PRO F N   1 
ATOM   599  C CA  . PRO A 1 105 ? 187.37000 328.73600 0.29800   1.000 93.88434  ? 101 PRO F CA  1 
ATOM   600  C C   . PRO A 1 105 ? 188.15700 328.72000 1.60600   1.000 91.26628  ? 101 PRO F C   1 
ATOM   601  O O   . PRO A 1 105 ? 188.04200 327.82700 2.45600   1.000 82.10199  ? 101 PRO F O   1 
ATOM   602  C CB  . PRO A 1 105 ? 185.96900 329.33600 0.53500   1.000 86.04009  ? 101 PRO F CB  1 
ATOM   603  C CG  . PRO A 1 105 ? 185.06700 328.65100 -0.43600  1.000 86.16161  ? 101 PRO F CG  1 
ATOM   604  C CD  . PRO A 1 105 ? 185.63300 327.26500 -0.59700  1.000 94.83280  ? 101 PRO F CD  1 
ATOM   605  N N   . ALA A 1 106 ? 188.98900 329.76600 1.70600   1.000 86.50861  ? 102 ALA F N   1 
ATOM   606  C CA  . ALA A 1 106 ? 189.85200 330.14900 2.81500   1.000 88.98324  ? 102 ALA F CA  1 
ATOM   607  C C   . ALA A 1 106 ? 189.42700 331.55200 3.26600   1.000 87.30842  ? 102 ALA F C   1 
ATOM   608  O O   . ALA A 1 106 ? 190.23300 332.33300 3.79300   1.000 82.26893  ? 102 ALA F O   1 
ATOM   609  C CB  . ALA A 1 106 ? 191.33300 330.10600 2.42600   1.000 77.29291  ? 102 ALA F CB  1 
ATOM   610  N N   . THR A 1 107 ? 188.14600 331.87800 2.99800   1.000 90.34744  ? 103 THR F N   1 
ATOM   611  C CA  . THR A 1 107 ? 187.48600 333.15800 3.30700   1.000 95.54157  ? 103 THR F CA  1 
ATOM   612  C C   . THR A 1 107 ? 187.33400 333.26700 4.83400   1.000 96.97154  ? 103 THR F C   1 
ATOM   613  O O   . THR A 1 107 ? 186.45600 332.64400 5.44800   1.000 86.92399  ? 103 THR F O   1 
ATOM   614  C CB  . THR A 1 107 ? 186.14800 333.26500 2.55200   1.000 93.17505  ? 103 THR F CB  1 
ATOM   615  O OG1 . THR A 1 107 ? 185.25900 332.19000 2.91100   1.000 88.27366  ? 103 THR F OG1 1 
ATOM   616  C CG2 . THR A 1 107 ? 186.33700 333.26800 0.99800   1.000 68.35104  ? 103 THR F CG2 1 
ATOM   617  N N   . GLY A 1 108 ? 188.19400 334.08000 5.44700   1.000 93.58522  ? 143 GLY F N   1 
ATOM   618  C CA  . GLY A 1 108 ? 188.15700 334.34400 6.87200   1.000 86.84080  ? 143 GLY F CA  1 
ATOM   619  C C   . GLY A 1 108 ? 189.15400 333.42400 7.55000   1.000 89.17621  ? 143 GLY F C   1 
ATOM   620  O O   . GLY A 1 108 ? 190.10200 332.93400 6.92600   1.000 89.48949  ? 143 GLY F O   1 
ATOM   621  N N   . SER A 1 109 ? 188.95400 333.19300 8.85100   1.000 88.07564  ? 144 SER F N   1 
ATOM   622  C CA  . SER A 1 109 ? 189.85400 332.27700 9.54900   1.000 81.90077  ? 144 SER F CA  1 
ATOM   623  C C   . SER A 1 109 ? 189.25400 330.88600 9.63600   1.000 77.52063  ? 144 SER F C   1 
ATOM   624  O O   . SER A 1 109 ? 189.89600 329.97900 10.18800  1.000 66.94573  ? 144 SER F O   1 
ATOM   625  C CB  . SER A 1 109 ? 190.17500 332.76900 10.97600  1.000 68.94052  ? 144 SER F CB  1 
ATOM   626  O OG  . SER A 1 109 ? 189.00900 332.92000 11.78500  1.000 68.03095  ? 144 SER F OG  1 
ATOM   627  N N   . GLY A 1 110 ? 188.08600 330.68800 9.00000   1.000 83.15364  ? 145 GLY F N   1 
ATOM   628  C CA  . GLY A 1 110 ? 187.33200 329.45000 9.03000   1.000 74.92864  ? 145 GLY F CA  1 
ATOM   629  C C   . GLY A 1 110 ? 187.40100 328.86900 10.42200  1.000 64.44103  ? 145 GLY F C   1 
ATOM   630  O O   . GLY A 1 110 ? 187.40700 327.64600 10.61200  1.000 59.96488  ? 145 GLY F O   1 
ATOM   631  N N   . SER A 1 111 ? 187.46100 329.76000 11.40900  1.000 58.13767  ? 146 SER F N   1 
ATOM   632  C CA  . SER A 1 111 ? 187.50800 329.32900 12.79000  1.000 54.05730  ? 146 SER F CA  1 
ATOM   633  C C   . SER A 1 111 ? 186.17100 328.82800 13.31200  1.000 51.99134  ? 146 SER F C   1 
ATOM   634  O O   . SER A 1 111 ? 186.14000 328.25300 14.40700  1.000 53.37479  ? 146 SER F O   1 
ATOM   635  C CB  . SER A 1 111 ? 188.03800 330.45900 13.67800  1.000 56.63033  ? 146 SER F CB  1 
ATOM   636  O OG  . SER A 1 111 ? 188.13000 330.01600 15.03400  1.000 51.07833  ? 146 SER F OG  1 
ATOM   637  N N   . ALA A 1 112 ? 185.09400 328.88000 12.54900  1.000 51.80434  ? 147 ALA F N   1 
ATOM   638  C CA  . ALA A 1 112 ? 183.84600 328.41600 13.11500  1.000 46.73461  ? 147 ALA F CA  1 
ATOM   639  C C   . ALA A 1 112 ? 183.29400 327.29500 12.28600  1.000 49.15877  ? 147 ALA F C   1 
ATOM   640  O O   . ALA A 1 112 ? 182.36900 326.61300 12.73900  1.000 50.91579  ? 147 ALA F O   1 
ATOM   641  C CB  . ALA A 1 112 ? 182.81000 329.54600 13.16800  1.000 41.10344  ? 147 ALA F CB  1 
ATOM   642  N N   . ILE A 1 113 ? 183.96900 326.97400 11.18500  1.000 46.85519  ? 148 ILE F N   1 
ATOM   643  C CA  . ILE A 1 113 ? 183.58200 325.92000 10.26900  1.000 43.56434  ? 148 ILE F CA  1 
ATOM   644  C C   . ILE A 1 113 ? 184.66000 324.86200 10.24000  1.000 45.97950  ? 148 ILE F C   1 
ATOM   645  O O   . ILE A 1 113 ? 184.50600 323.84000 9.56300   1.000 46.98997  ? 148 ILE F O   1 
ATOM   646  C CB  . ILE A 1 113 ? 183.29500 326.42300 8.83900   1.000 42.22656  ? 148 ILE F CB  1 
ATOM   647  C CG1 . ILE A 1 113 ? 184.52900 327.06100 8.22400   1.000 42.25696  ? 148 ILE F CG1 1 
ATOM   648  C CG2 . ILE A 1 113 ? 182.08900 327.35900 8.79900   1.000 41.12500  ? 148 ILE F CG2 1 
ATOM   649  C CD1 . ILE A 1 113 ? 184.27300 327.52200 6.84000   1.000 39.01033  ? 148 ILE F CD1 1 
ATOM   650  N N   . ALA A 1 114 ? 185.75800 325.09400 10.96400  1.000 43.63648  ? 149 ALA F N   1 
ATOM   651  C CA  . ALA A 1 114 ? 186.82500 324.11700 11.04200  1.000 39.05628  ? 149 ALA F CA  1 
ATOM   652  C C   . ALA A 1 114 ? 186.27100 322.72100 11.26600  1.000 38.71523  ? 149 ALA F C   1 
ATOM   653  O O   . ALA A 1 114 ? 186.72200 321.76800 10.63000  1.000 44.25186  ? 149 ALA F O   1 
ATOM   654  C CB  . ALA A 1 114 ? 187.79500 324.49800 12.15800  1.000 41.62107  ? 149 ALA F CB  1 
ATOM   655  N N   . SER A 1 115 ? 185.29000 322.57500 12.15900  1.000 39.13964  ? 150 SER F N   1 
ATOM   656  C CA  . SER A 1 115 ? 184.77600 321.23700 12.45600  1.000 42.25515  ? 150 SER F CA  1 
ATOM   657  C C   . SER A 1 115 ? 184.26900 320.52700 11.20500  1.000 44.51948  ? 150 SER F C   1 
ATOM   658  O O   . SER A 1 115 ? 184.57100 319.34500 10.99400  1.000 42.59002  ? 150 SER F O   1 
ATOM   659  C CB  . SER A 1 115 ? 183.67600 321.30500 13.50700  1.000 40.98459  ? 150 SER F CB  1 
ATOM   660  O OG  . SER A 1 115 ? 184.23700 321.14300 14.79200  1.000 47.88666  ? 150 SER F OG  1 
ATOM   661  N N   . GLY A 1 116 ? 183.48400 321.22600 10.37300  1.000 42.44813  ? 151 GLY F N   1 
ATOM   662  C CA  . GLY A 1 116 ? 183.04000 320.65600 9.11200   1.000 43.01400  ? 151 GLY F CA  1 
ATOM   663  C C   . GLY A 1 116 ? 184.10400 320.60500 8.02300   1.000 48.18826  ? 151 GLY F C   1 
ATOM   664  O O   . GLY A 1 116 ? 184.10500 319.68000 7.19800   1.000 52.88233  ? 151 GLY F O   1 
ATOM   665  N N   . VAL A 1 117 ? 185.00100 321.59400 7.97600   1.000 42.95502  ? 152 VAL F N   1 
ATOM   666  C CA  . VAL A 1 117 ? 186.05200 321.54600 6.97000   1.000 40.77721  ? 152 VAL F CA  1 
ATOM   667  C C   . VAL A 1 117 ? 186.91900 320.31600 7.19500   1.000 44.43724  ? 152 VAL F C   1 
ATOM   668  O O   . VAL A 1 117 ? 187.43400 319.71300 6.23500   1.000 49.29514  ? 152 VAL F O   1 
ATOM   669  C CB  . VAL A 1 117 ? 186.86000 322.85200 6.99200   1.000 41.29534  ? 152 VAL F CB  1 
ATOM   670  C CG1 . VAL A 1 117 ? 188.16600 322.69800 6.22900   1.000 34.39618  ? 152 VAL F CG1 1 
ATOM   671  C CG2 . VAL A 1 117 ? 186.01100 323.99000 6.41500   1.000 39.19463  ? 152 VAL F CG2 1 
ATOM   672  N N   . ALA A 1 118 ? 187.11200 319.92800 8.46200   1.000 44.80306  ? 153 ALA F N   1 
ATOM   673  C CA  . ALA A 1 118 ? 187.87400 318.71600 8.73500   1.000 49.60753  ? 153 ALA F CA  1 
ATOM   674  C C   . ALA A 1 118 ? 187.17900 317.47300 8.18800   1.000 50.78683  ? 153 ALA F C   1 
ATOM   675  O O   . ALA A 1 118 ? 187.85500 316.53100 7.75400   1.000 49.60314  ? 153 ALA F O   1 
ATOM   676  C CB  . ALA A 1 118 ? 188.08300 318.56300 10.24000  1.000 47.92570  ? 153 ALA F CB  1 
ATOM   677  N N   . VAL A 1 119 ? 185.84000 317.47500 8.13300   1.000 50.88618  ? 154 VAL F N   1 
ATOM   678  C CA  . VAL A 1 119 ? 185.12200 316.32100 7.59700   1.000 49.76920  ? 154 VAL F CA  1 
ATOM   679  C C   . VAL A 1 119 ? 185.22100 316.31100 6.08300   1.000 53.06746  ? 154 VAL F C   1 
ATOM   680  O O   . VAL A 1 119 ? 185.35800 315.24800 5.46300   1.000 55.56769  ? 154 VAL F O   1 
ATOM   681  C CB  . VAL A 1 119 ? 183.66400 316.27200 8.07900   1.000 46.46200  ? 154 VAL F CB  1 
ATOM   682  C CG1 . VAL A 1 119 ? 183.01400 315.02800 7.57500   1.000 47.25392  ? 154 VAL F CG1 1 
ATOM   683  C CG2 . VAL A 1 119 ? 183.62600 316.18500 9.58400   1.000 38.54710  ? 154 VAL F CG2 1 
ATOM   684  N N   . CYS A 1 120 ? 185.19100 317.49700 5.46900   1.000 50.15244  ? 155 CYS F N   1 
ATOM   685  C CA  . CYS A 1 120 ? 185.31800 317.54500 4.02000   1.000 52.01347  ? 155 CYS F CA  1 
ATOM   686  C C   . CYS A 1 120 ? 186.68400 317.05100 3.59900   1.000 57.25189  ? 155 CYS F C   1 
ATOM   687  O O   . CYS A 1 120 ? 186.81900 316.43900 2.53800   1.000 61.51426  ? 155 CYS F O   1 
ATOM   688  C CB  . CYS A 1 120 ? 185.11700 318.95400 3.48500   1.000 53.76528  ? 155 CYS F CB  1 
ATOM   689  S SG  . CYS A 1 120 ? 183.39400 319.56300 3.48400   1.000 91.27856  ? 155 CYS F SG  1 
ATOM   690  N N   . LYS A 1 121 ? 187.71700 317.28900 4.41100   1.000 58.84939  ? 156 LYS F N   1 
ATOM   691  C CA  . LYS A 1 121 ? 189.01300 316.77400 3.98000   1.000 56.89291  ? 156 LYS F CA  1 
ATOM   692  C C   . LYS A 1 121 ? 189.05100 315.24700 4.02100   1.000 55.56816  ? 156 LYS F C   1 
ATOM   693  O O   . LYS A 1 121 ? 189.72400 314.62700 3.19400   1.000 58.48923  ? 156 LYS F O   1 
ATOM   694  C CB  . LYS A 1 121 ? 190.11400 317.34200 4.86800   1.000 56.52890  ? 156 LYS F CB  1 
ATOM   695  C CG  . LYS A 1 121 ? 190.73200 318.65000 4.38500   1.000 60.38798  ? 156 LYS F CG  1 
ATOM   696  C CD  . LYS A 1 121 ? 192.18800 318.78800 4.84200   1.000 64.68192  ? 156 LYS F CD  1 
ATOM   697  C CE  . LYS A 1 121 ? 192.93700 317.46500 4.67200   1.000 58.57230  ? 156 LYS F CE  1 
ATOM   698  N NZ  . LYS A 1 121 ? 194.30700 317.48800 5.26000   1.000 49.68411  ? 156 LYS F NZ  1 
ATOM   699  N N   . VAL A 1 122 ? 188.29500 314.63500 4.93100   1.000 53.03908  ? 157 VAL F N   1 
ATOM   700  C CA  . VAL A 1 122 ? 188.19300 313.17900 5.03300   1.000 57.50146  ? 157 VAL F CA  1 
ATOM   701  C C   . VAL A 1 122 ? 187.38800 312.60700 3.87400   1.000 62.58231  ? 157 VAL F C   1 
ATOM   702  O O   . VAL A 1 122 ? 187.65400 311.50300 3.37600   1.000 60.38182  ? 157 VAL F O   1 
ATOM   703  C CB  . VAL A 1 122 ? 187.58200 312.76600 6.38100   1.000 59.48707  ? 157 VAL F CB  1 
ATOM   704  C CG1 . VAL A 1 122 ? 187.39700 311.22500 6.42500   1.000 69.20677  ? 157 VAL F CG1 1 
ATOM   705  C CG2 . VAL A 1 122 ? 188.48600 313.24700 7.52000   1.000 64.34872  ? 157 VAL F CG2 1 
ATOM   706  N N   . LEU A 1 123 ? 186.36000 313.33400 3.46500   1.000 59.74020  ? 158 LEU F N   1 
ATOM   707  C CA  . LEU A 1 123 ? 185.49600 312.85400 2.41100   1.000 56.57377  ? 158 LEU F CA  1 
ATOM   708  C C   . LEU A 1 123 ? 186.25700 312.73600 1.09500   1.000 56.90529  ? 158 LEU F C   1 
ATOM   709  O O   . LEU A 1 123 ? 185.96200 311.84600 0.29000   1.000 64.64260  ? 158 LEU F O   1 
ATOM   710  C CB  . LEU A 1 123 ? 184.33900 313.84000 2.32700   1.000 58.13747  ? 158 LEU F CB  1 
ATOM   711  C CG  . LEU A 1 123 ? 183.28100 313.29500 3.28200   1.000 56.49124  ? 158 LEU F CG  1 
ATOM   712  C CD1 . LEU A 1 123 ? 182.04000 314.15100 3.30900   1.000 56.19122  ? 158 LEU F CD1 1 
ATOM   713  C CD2 . LEU A 1 123 ? 182.98200 311.83500 3.02400   1.000 62.97875  ? 158 LEU F CD2 1 
ATOM   714  N N   . HIS A 1 124 ? 187.27900 313.56900 0.89600   1.000 54.37252  ? 159 HIS F N   1 
ATOM   715  C CA  . HIS A 1 124 ? 188.13700 313.56000 -0.28900  1.000 58.74243  ? 159 HIS F CA  1 
ATOM   716  C C   . HIS A 1 124 ? 189.07000 312.34500 -0.36300  1.000 68.38939  ? 159 HIS F C   1 
ATOM   717  O O   . HIS A 1 124 ? 189.74300 312.16500 -1.38700  1.000 67.29608  ? 159 HIS F O   1 
ATOM   718  C CB  . HIS A 1 124 ? 188.97900 314.82800 -0.36600  1.000 56.27581  ? 159 HIS F CB  1 
ATOM   719  C CG  . HIS A 1 124 ? 188.24200 316.01600 -0.89400  1.000 56.24937  ? 159 HIS F CG  1 
ATOM   720  N ND1 . HIS A 1 124 ? 187.17300 316.58100 -0.23700  1.000 59.72645  ? 159 HIS F ND1 1 
ATOM   721  C CD2 . HIS A 1 124 ? 188.40000 316.72700 -2.03400  1.000 59.80119  ? 159 HIS F CD2 1 
ATOM   722  C CE1 . HIS A 1 124 ? 186.72100 317.60800 -0.93400  1.000 60.11457  ? 159 HIS F CE1 1 
ATOM   723  N NE2 . HIS A 1 124 ? 187.44500 317.71500 -2.03200  1.000 63.14216  ? 159 HIS F NE2 1 
ATOM   724  N N   . LEU A 1 125 ? 189.19800 311.56500 0.71200   1.000 67.90175  ? 160 LEU F N   1 
ATOM   725  C CA  . LEU A 1 125 ? 190.00400 310.34800 0.67800   1.000 66.00364  ? 160 LEU F CA  1 
ATOM   726  C C   . LEU A 1 125 ? 189.39400 309.27700 -0.22100  1.000 69.85505  ? 160 LEU F C   1 
ATOM   727  O O   . LEU A 1 125 ? 188.16600 309.14700 -0.34700  1.000 67.21347  ? 160 LEU F O   1 
ATOM   728  C CB  . LEU A 1 125 ? 190.18900 309.77000 2.07400   1.000 67.82029  ? 160 LEU F CB  1 
ATOM   729  C CG  . LEU A 1 125 ? 190.83600 310.70100 3.09500   1.000 71.46382  ? 160 LEU F CG  1 
ATOM   730  C CD1 . LEU A 1 125 ? 190.99400 309.96400 4.43300   1.000 68.67896  ? 160 LEU F CD1 1 
ATOM   731  C CD2 . LEU A 1 125 ? 192.15200 311.30500 2.57300   1.000 62.21534  ? 160 LEU F CD2 1 
ATOM   732  N N   . GLU A 1 126 ? 190.27800 308.43900 -0.77200  1.000 71.74822  ? 161 GLU F N   1 
ATOM   733  C CA  . GLU A 1 126 ? 189.84700 307.39200 -1.68500  1.000 74.53934  ? 161 GLU F CA  1 
ATOM   734  C C   . GLU A 1 126 ? 189.10300 306.32900 -0.91500  1.000 71.30847  ? 161 GLU F C   1 
ATOM   735  O O   . GLU A 1 126 ? 189.57000 305.86600 0.13000   1.000 64.92888  ? 161 GLU F O   1 
ATOM   736  C CB  . GLU A 1 126 ? 191.05300 306.76100 -2.38300  1.000 68.65254  ? 161 GLU F CB  1 
ATOM   737  C CG  . GLU A 1 126 ? 192.23200 307.69600 -2.48800  1.000 80.73141  ? 161 GLU F CG  1 
ATOM   738  C CD  . GLU A 1 126 ? 192.20600 308.54200 -3.77000  1.000 95.48137  ? 161 GLU F CD  1 
ATOM   739  O OE1 . GLU A 1 126 ? 191.25400 308.40300 -4.58600  1.000 85.91977  ? 161 GLU F OE1 1 
ATOM   740  O OE2 . GLU A 1 126 ? 193.13700 309.36600 -3.94500  1.000 101.46711 ? 161 GLU F OE2 1 
ATOM   741  N N   . GLY A 1 127 ? 187.89200 306.02400 -1.37800  1.000 70.13248  ? 162 GLY F N   1 
ATOM   742  C CA  . GLY A 1 127 ? 187.08300 305.02000 -0.74300  1.000 68.01266  ? 162 GLY F CA  1 
ATOM   743  C C   . GLY A 1 127 ? 186.09000 305.56400 0.24900   1.000 74.73072  ? 162 GLY F C   1 
ATOM   744  O O   . GLY A 1 127 ? 185.23300 304.80600 0.71700   1.000 76.19314  ? 162 GLY F O   1 
ATOM   745  N N   . GLU A 1 128 ? 186.21100 306.83300 0.63600   1.000 74.95854  ? 163 GLU F N   1 
ATOM   746  C CA  . GLU A 1 128 ? 185.29100 307.32300 1.64900   1.000 68.99524  ? 163 GLU F CA  1 
ATOM   747  C C   . GLU A 1 128 ? 183.94200 307.71600 1.06800   1.000 68.38429  ? 163 GLU F C   1 
ATOM   748  O O   . GLU A 1 128 ? 182.89400 307.40300 1.65800   1.000 67.25302  ? 163 GLU F O   1 
ATOM   749  C CB  . GLU A 1 128 ? 185.92500 308.49400 2.38400   1.000 72.40338  ? 163 GLU F CB  1 
ATOM   750  C CG  . GLU A 1 128 ? 187.31400 308.15400 2.87700   1.000 78.49473  ? 163 GLU F CG  1 
ATOM   751  C CD  . GLU A 1 128 ? 187.34500 307.79400 4.35400   1.000 86.56703  ? 163 GLU F CD  1 
ATOM   752  O OE1 . GLU A 1 128 ? 186.29400 307.91900 5.03000   1.000 82.25677  ? 163 GLU F OE1 1 
ATOM   753  O OE2 . GLU A 1 128 ? 188.42800 307.38100 4.83500   1.000 94.97011  ? 163 GLU F OE2 1 
ATOM   754  N N   . VAL A 1 129 ? 183.92200 308.35000 -0.10700  1.000 70.02717  ? 164 VAL F N   1 
ATOM   755  C CA  . VAL A 1 129 ? 182.60000 308.58700 -0.66200  1.000 68.11458  ? 164 VAL F CA  1 
ATOM   756  C C   . VAL A 1 129 ? 181.96900 307.25400 -1.00100  1.000 69.79542  ? 164 VAL F C   1 
ATOM   757  O O   . VAL A 1 129 ? 180.74700 307.08800 -0.88400  1.000 67.59242  ? 164 VAL F O   1 
ATOM   758  C CB  . VAL A 1 129 ? 182.69900 309.49600 -1.89700  1.000 67.74311  ? 164 VAL F CB  1 
ATOM   759  C CG1 . VAL A 1 129 ? 183.03200 310.91500 -1.47800  1.000 60.82442  ? 164 VAL F CG1 1 
ATOM   760  C CG2 . VAL A 1 129 ? 183.76600 308.94400 -2.84500  1.000 72.54906  ? 164 VAL F CG2 1 
ATOM   761  N N   . ASN A 1 130 ? 182.79900 306.25400 -1.32100  1.000 71.40879  ? 165 ASN F N   1 
ATOM   762  C CA  . ASN A 1 130 ? 182.28100 304.91500 -1.56700  1.000 75.19498  ? 165 ASN F CA  1 
ATOM   763  C C   . ASN A 1 130 ? 181.75200 304.29200 -0.28000  1.000 71.65625  ? 165 ASN F C   1 
ATOM   764  O O   . ASN A 1 130 ? 180.77300 303.53100 -0.30500  1.000 70.21232  ? 165 ASN F O   1 
ATOM   765  C CB  . ASN A 1 130 ? 183.35800 304.05100 -2.21300  1.000 76.09373  ? 165 ASN F CB  1 
ATOM   766  C CG  . ASN A 1 130 ? 182.82400 303.26500 -3.37900  1.000 80.80903  ? 165 ASN F CG  1 
ATOM   767  O OD1 . ASN A 1 130 ? 181.70300 302.74700 -3.33000  1.000 78.28887  ? 165 ASN F OD1 1 
ATOM   768  N ND2 . ASN A 1 130 ? 183.59700 303.20800 -4.45700  1.000 82.44303  ? 165 ASN F ND2 1 
ATOM   769  N N   . LYS A 1 131 ? 182.29000 304.72400 0.86400   1.000 70.37325  ? 166 LYS F N   1 
ATOM   770  C CA  . LYS A 1 131 ? 181.86000 304.17300 2.14200   1.000 70.90717  ? 166 LYS F CA  1 
ATOM   771  C C   . LYS A 1 131 ? 180.48000 304.69300 2.46700   1.000 70.89707  ? 166 LYS F C   1 
ATOM   772  O O   . LYS A 1 131 ? 179.58300 303.92400 2.84100   1.000 70.92333  ? 166 LYS F O   1 
ATOM   773  C CB  . LYS A 1 131 ? 182.82500 304.52700 3.28100   1.000 76.82851  ? 166 LYS F CB  1 
ATOM   774  C CG  . LYS A 1 131 ? 184.20000 303.85400 3.28600   1.000 77.48553  ? 166 LYS F CG  1 
ATOM   775  C CD  . LYS A 1 131 ? 184.98900 304.27100 4.54800   1.000 85.63182  ? 166 LYS F CD  1 
ATOM   776  C CE  . LYS A 1 131 ? 184.04500 304.51600 5.74900   1.000 86.04698  ? 166 LYS F CE  1 
ATOM   777  N NZ  . LYS A 1 131 ? 184.74800 304.91700 7.00700   1.000 88.44639  ? 166 LYS F NZ  1 
ATOM   778  N N   . ILE A 1 132 ? 180.31300 306.01500 2.40000   1.000 69.45695  ? 167 ILE F N   1 
ATOM   779  C CA  . ILE A 1 132 ? 178.98500 306.55300 2.65900   1.000 70.55926  ? 167 ILE F CA  1 
ATOM   780  C C   . ILE A 1 132 ? 177.99400 306.05500 1.62600   1.000 68.56771  ? 167 ILE F C   1 
ATOM   781  O O   . ILE A 1 132 ? 176.81900 305.82000 1.94400   1.000 68.43132  ? 167 ILE F O   1 
ATOM   782  C CB  . ILE A 1 132 ? 179.01000 308.08700 2.62000   1.000 68.17446  ? 167 ILE F CB  1 
ATOM   783  C CG1 . ILE A 1 132 ? 180.25700 308.63600 3.29800   1.000 67.27442  ? 167 ILE F CG1 1 
ATOM   784  C CG2 . ILE A 1 132 ? 177.73100 308.62300 3.24300   1.000 61.09174  ? 167 ILE F CG2 1 
ATOM   785  C CD1 . ILE A 1 132 ? 180.25400 310.13700 3.34900   1.000 63.62184  ? 167 ILE F CD1 1 
ATOM   786  N N   . LYS A 1 133 ? 178.46100 305.80900 0.39800   1.000 65.95736  ? 168 LYS F N   1 
ATOM   787  C CA  . LYS A 1 133 ? 177.57100 305.28900 -0.62700  1.000 66.70191  ? 168 LYS F CA  1 
ATOM   788  C C   . LYS A 1 133 ? 177.10700 303.88500 -0.28200  1.000 72.51302  ? 168 LYS F C   1 
ATOM   789  O O   . LYS A 1 133 ? 175.95700 303.52400 -0.57700  1.000 72.78472  ? 168 LYS F O   1 
ATOM   790  C CB  . LYS A 1 133 ? 178.32500 305.33100 -1.95400  1.000 63.65809  ? 168 LYS F CB  1 
ATOM   791  C CG  . LYS A 1 133 ? 177.56600 305.17800 -3.23900  1.000 61.73394  ? 168 LYS F CG  1 
ATOM   792  C CD  . LYS A 1 133 ? 178.60100 305.37600 -4.33000  1.000 58.98651  ? 168 LYS F CD  1 
ATOM   793  C CE  . LYS A 1 133 ? 178.04300 305.34900 -5.72000  1.000 64.60986  ? 168 LYS F CE  1 
ATOM   794  N NZ  . LYS A 1 133 ? 179.16400 305.58200 -6.67100  1.000 64.39700  ? 168 LYS F NZ  1 
ATOM   795  N N   . SER A 1 134 ? 177.93100 303.14700 0.47600   1.000 72.45089  ? 169 SER F N   1 
ATOM   796  C CA  . SER A 1 134 ? 177.56100 301.79600 0.88600   1.000 71.70248  ? 169 SER F CA  1 
ATOM   797  C C   . SER A 1 134 ? 176.69800 301.78600 2.13500   1.000 70.23646  ? 169 SER F C   1 
ATOM   798  O O   . SER A 1 134 ? 175.73600 301.01300 2.21700   1.000 72.75125  ? 169 SER F O   1 
ATOM   799  C CB  . SER A 1 134 ? 178.81000 300.95000 1.14400   1.000 72.18391  ? 169 SER F CB  1 
ATOM   800  O OG  . SER A 1 134 ? 179.64300 300.87900 0.00200   1.000 81.14091  ? 169 SER F OG  1 
ATOM   801  N N   . ALA A 1 135 ? 176.97700 302.65900 3.09600   1.000 69.81270  ? 170 ALA F N   1 
ATOM   802  C CA  . ALA A 1 135 ? 176.17200 302.61600 4.30700   1.000 70.98039  ? 170 ALA F CA  1 
ATOM   803  C C   . ALA A 1 135 ? 174.73600 303.05600 4.03300   1.000 71.92983  ? 170 ALA F C   1 
ATOM   804  O O   . ALA A 1 135 ? 173.79400 302.53600 4.65000   1.000 69.97419  ? 170 ALA F O   1 
ATOM   805  C CB  . ALA A 1 135 ? 176.82300 303.47500 5.38600   1.000 69.70770  ? 170 ALA F CB  1 
ATOM   806  N N   . LEU A 1 136 ? 174.54200 304.03200 3.13500   1.000 71.05800  ? 171 LEU F N   1 
ATOM   807  C CA  . LEU A 1 136 ? 173.20300 304.47600 2.76300   1.000 70.09543  ? 171 LEU F CA  1 
ATOM   808  C C   . LEU A 1 136 ? 172.67400 303.74900 1.54500   1.000 72.76010  ? 171 LEU F C   1 
ATOM   809  O O   . LEU A 1 136 ? 171.87000 304.31300 0.79000   1.000 75.65819  ? 171 LEU F O   1 
ATOM   810  C CB  . LEU A 1 136 ? 173.23200 305.97000 2.46600   1.000 66.39989  ? 171 LEU F CB  1 
ATOM   811  C CG  . LEU A 1 136 ? 173.56500 306.95900 3.55800   1.000 58.01011  ? 171 LEU F CG  1 
ATOM   812  C CD1 . LEU A 1 136 ? 173.50900 308.34100 2.92400   1.000 55.90621  ? 171 LEU F CD1 1 
ATOM   813  C CD2 . LEU A 1 136 ? 172.56500 306.80100 4.69700   1.000 58.99193  ? 171 LEU F CD2 1 
ATOM   814  N N   . LEU A 1 137 ? 173.03000 302.48500 1.37200   1.000 77.16724  ? 172 LEU F N   1 
ATOM   815  C CA  . LEU A 1 137 ? 172.56000 301.78000 0.19200   1.000 80.04328  ? 172 LEU F CA  1 
ATOM   816  C C   . LEU A 1 137 ? 171.13400 301.27000 0.38100   1.000 76.88595  ? 172 LEU F C   1 
ATOM   817  O O   . LEU A 1 137 ? 170.35700 301.23400 -0.58000  1.000 74.91147  ? 172 LEU F O   1 
ATOM   818  C CB  . LEU A 1 137 ? 173.54300 300.68200 -0.18500  1.000 81.05261  ? 172 LEU F CB  1 
ATOM   819  C CG  . LEU A 1 137 ? 173.12400 299.99600 -1.47200  1.000 76.43969  ? 172 LEU F CG  1 
ATOM   820  C CD1 . LEU A 1 137 ? 172.45600 301.04600 -2.38800  1.000 72.53573  ? 172 LEU F CD1 1 
ATOM   821  C CD2 . LEU A 1 137 ? 174.39500 299.47700 -2.12900  1.000 70.42597  ? 172 LEU F CD2 1 
ATOM   822  N N   . SER A 1 138 ? 170.75200 300.94900 1.62200   1.000 77.01018  ? 173 SER F N   1 
ATOM   823  C CA  . SER A 1 138 ? 169.45600 300.35300 1.91200   1.000 73.54541  ? 173 SER F CA  1 
ATOM   824  C C   . SER A 1 138 ? 168.58700 301.24100 2.78000   1.000 73.96059  ? 173 SER F C   1 
ATOM   825  O O   . SER A 1 138 ? 167.37600 301.00300 2.82900   1.000 71.27337  ? 173 SER F O   1 
ATOM   826  C CB  . SER A 1 138 ? 169.61700 298.99900 2.62200   1.000 75.27986  ? 173 SER F CB  1 
ATOM   827  O OG  . SER A 1 138 ? 170.73000 298.28600 2.11500   1.000 78.85256  ? 173 SER F OG  1 
ATOM   828  N N   . THR A 1 139 ? 169.17100 302.15300 3.56800   1.000 78.44719  ? 174 THR F N   1 
ATOM   829  C CA  . THR A 1 139 ? 168.40300 303.02000 4.45800   1.000 77.62590  ? 174 THR F CA  1 
ATOM   830  C C   . THR A 1 139 ? 168.79300 304.47200 4.11800   1.000 76.67293  ? 174 THR F C   1 
ATOM   831  O O   . THR A 1 139 ? 169.77700 304.71600 3.40000   1.000 73.85948  ? 174 THR F O   1 
ATOM   832  C CB  . THR A 1 139 ? 168.61900 302.64100 5.94400   1.000 70.81602  ? 174 THR F CB  1 
ATOM   833  O OG1 . THR A 1 139 ? 168.01900 303.62000 6.80900   1.000 72.57126  ? 174 THR F OG1 1 
ATOM   834  C CG2 . THR A 1 139 ? 170.11000 302.45800 6.27300   1.000 67.82712  ? 174 THR F CG2 1 
ATOM   835  N N   . ASN A 1 140 ? 168.00000 305.45000 4.60700   1.000 73.15571  ? 175 ASN F N   1 
ATOM   836  C CA  . ASN A 1 140 ? 168.30900 306.87900 4.41200   1.000 71.23315  ? 175 ASN F CA  1 
ATOM   837  C C   . ASN A 1 140 ? 169.31400 307.46100 5.40300   1.000 65.31235  ? 175 ASN F C   1 
ATOM   838  O O   . ASN A 1 140 ? 170.05700 308.38600 5.06300   1.000 58.88702  ? 175 ASN F O   1 
ATOM   839  C CB  . ASN A 1 140 ? 167.02900 307.70200 4.44700   1.000 69.23296  ? 175 ASN F CB  1 
ATOM   840  C CG  . ASN A 1 140 ? 166.07500 307.31500 3.35900   1.000 70.37522  ? 175 ASN F CG  1 
ATOM   841  O OD1 . ASN A 1 140 ? 166.49800 306.87700 2.27300   1.000 63.39610  ? 175 ASN F OD1 1 
ATOM   842  N ND2 . ASN A 1 140 ? 164.77800 307.44000 3.64000   1.000 74.83118  ? 175 ASN F ND2 1 
ATOM   843  N N   . LYS A 1 141 ? 169.22000 307.08400 6.66400   1.000 67.50948  ? 176 LYS F N   1 
ATOM   844  C CA  . LYS A 1 141 ? 170.12000 307.59300 7.67800   1.000 62.49585  ? 176 LYS F CA  1 
ATOM   845  C C   . LYS A 1 141 ? 170.97000 306.46800 8.24500   1.000 63.99595  ? 176 LYS F C   1 
ATOM   846  O O   . LYS A 1 141 ? 170.50500 305.33700 8.41100   1.000 64.97658  ? 176 LYS F O   1 
ATOM   847  C CB  . LYS A 1 141 ? 169.32000 308.39100 8.70600   1.000 58.56500  ? 176 LYS F CB  1 
ATOM   848  C CG  . LYS A 1 141 ? 168.40300 307.67100 9.64900   1.000 57.57299  ? 176 LYS F CG  1 
ATOM   849  C CD  . LYS A 1 141 ? 167.71200 308.80100 10.42100  1.000 64.59818  ? 176 LYS F CD  1 
ATOM   850  C CE  . LYS A 1 141 ? 166.69400 308.38700 11.46100  1.000 70.41872  ? 176 LYS F CE  1 
ATOM   851  N NZ  . LYS A 1 141 ? 165.33600 308.86500 11.02600  1.000 66.70521  ? 176 LYS F NZ  1 
ATOM   852  N N   . ALA A 1 142 ? 172.20000 306.81100 8.61600   1.000 65.50296  ? 177 ALA F N   1 
ATOM   853  C CA  . ALA A 1 142 ? 173.08200 305.79100 9.16400   1.000 61.59060  ? 177 ALA F CA  1 
ATOM   854  C C   . ALA A 1 142 ? 174.31400 306.44700 9.76600   1.000 61.45360  ? 177 ALA F C   1 
ATOM   855  O O   . ALA A 1 142 ? 174.85500 307.39500 9.19700   1.000 60.66381  ? 177 ALA F O   1 
ATOM   856  C CB  . ALA A 1 142 ? 173.49600 304.78600 8.08000   1.000 59.32777  ? 177 ALA F CB  1 
ATOM   857  N N   . VAL A 1 143 ? 174.78300 305.89900 10.87800  1.000 64.06145  ? 178 VAL F N   1 
ATOM   858  C CA  . VAL A 1 143 ? 176.01200 306.37200 11.49800  1.000 60.60168  ? 178 VAL F CA  1 
ATOM   859  C C   . VAL A 1 143 ? 177.18100 305.68400 10.81400  1.000 61.28591  ? 178 VAL F C   1 
ATOM   860  O O   . VAL A 1 143 ? 177.12100 304.49500 10.48900  1.000 63.30590  ? 178 VAL F O   1 
ATOM   861  C CB  . VAL A 1 143 ? 176.00200 306.09800 13.00800  1.000 58.10939  ? 178 VAL F CB  1 
ATOM   862  C CG1 . VAL A 1 143 ? 177.33600 306.49400 13.60700  1.000 61.62440  ? 178 VAL F CG1 1 
ATOM   863  C CG2 . VAL A 1 143 ? 174.83900 306.82500 13.67800  1.000 52.73251  ? 178 VAL F CG2 1 
ATOM   864  N N   . VAL A 1 144 ? 178.21600 306.44900 10.51100  1.000 59.85236  ? 179 VAL F N   1 
ATOM   865  C CA  . VAL A 1 144 ? 179.37500 305.94500 9.80000   1.000 66.62285  ? 179 VAL F CA  1 
ATOM   866  C C   . VAL A 1 144 ? 180.64900 306.34100 10.53400  1.000 82.06659  ? 179 VAL F C   1 
ATOM   867  O O   . VAL A 1 144 ? 180.87500 307.52400 10.82800  1.000 84.71707  ? 179 VAL F O   1 
ATOM   868  C CB  . VAL A 1 144 ? 179.39500 306.44900 8.35400   1.000 65.50055  ? 179 VAL F CB  1 
ATOM   869  C CG1 . VAL A 1 144 ? 180.63900 305.94000 7.63500   1.000 74.69409  ? 179 VAL F CG1 1 
ATOM   870  C CG2 . VAL A 1 144 ? 178.14200 306.00900 7.68300   1.000 58.53506  ? 179 VAL F CG2 1 
ATOM   871  N N   . SER A 1 145 ? 181.48700 305.34600 10.80000  1.000 90.27685  ? 180 SER F N   1 
ATOM   872  C CA  . SER A 1 145 ? 182.80500 305.53800 11.39000  1.000 96.06004  ? 180 SER F CA  1 
ATOM   873  C C   . SER A 1 145 ? 183.74600 305.73600 10.21700  1.000 93.14497  ? 180 SER F C   1 
ATOM   874  O O   . SER A 1 145 ? 183.90300 304.85600 9.36300   1.000 87.05152  ? 180 SER F O   1 
ATOM   875  C CB  . SER A 1 145 ? 183.25000 304.37900 12.28100  1.000 99.47942  ? 180 SER F CB  1 
ATOM   876  O OG  . SER A 1 145 ? 184.52700 304.66000 12.86700  1.000 93.74482  ? 180 SER F OG  1 
ATOM   877  N N   . LEU A 1 146 ? 184.26500 306.94400 10.12200  1.000 92.29823  ? 181 LEU F N   1 
ATOM   878  C CA  . LEU A 1 146 ? 185.13400 307.36200 9.04900   1.000 96.15089  ? 181 LEU F CA  1 
ATOM   879  C C   . LEU A 1 146 ? 186.53100 306.76800 9.28400   1.000 98.54120  ? 181 LEU F C   1 
ATOM   880  O O   . LEU A 1 146 ? 186.78800 306.10100 10.29600  1.000 99.42739  ? 181 LEU F O   1 
ATOM   881  C CB  . LEU A 1 146 ? 185.15400 308.88800 9.05800   1.000 95.54656  ? 181 LEU F CB  1 
ATOM   882  C CG  . LEU A 1 146 ? 184.06700 309.60800 8.25700   1.000 92.06036  ? 181 LEU F CG  1 
ATOM   883  C CD1 . LEU A 1 146 ? 184.06200 311.09200 8.62700   1.000 82.36472  ? 181 LEU F CD1 1 
ATOM   884  C CD2 . LEU A 1 146 ? 184.19700 309.38400 6.76000   1.000 86.82204  ? 181 LEU F CD2 1 
ATOM   885  N N   . SER A 1 147 ? 187.46100 307.00300 8.35400   1.000 97.88066  ? 182 SER F N   1 
ATOM   886  C CA  . SER A 1 147 ? 188.80400 306.46300 8.54900   1.000 100.68819 ? 182 SER F CA  1 
ATOM   887  C C   . SER A 1 147 ? 189.63700 307.41000 9.39200   1.000 102.71050 ? 182 SER F C   1 
ATOM   888  O O   . SER A 1 147 ? 190.58200 306.97300 10.06700  1.000 99.72121  ? 182 SER F O   1 
ATOM   889  C CB  . SER A 1 147 ? 189.49600 306.19400 7.20600   1.000 94.17979  ? 182 SER F CB  1 
ATOM   890  O OG  . SER A 1 147 ? 188.83100 305.17200 6.47000   1.000 94.23233  ? 182 SER F OG  1 
ATOM   891  N N   . ASN A 1 148 ? 189.28400 308.69900 9.36500   1.000 100.23817 ? 183 ASN F N   1 
ATOM   892  C CA  . ASN A 1 148 ? 189.96300 309.67600 10.20400  1.000 103.19320 ? 183 ASN F CA  1 
ATOM   893  C C   . ASN A 1 148 ? 189.59200 309.46700 11.65700  1.000 100.20842 ? 183 ASN F C   1 
ATOM   894  O O   . ASN A 1 148 ? 190.36800 309.81000 12.55500  1.000 99.84134  ? 183 ASN F O   1 
ATOM   895  C CB  . ASN A 1 148 ? 189.59200 311.10200 9.79600   1.000 105.56555 ? 183 ASN F CB  1 
ATOM   896  C CG  . ASN A 1 148 ? 190.63300 312.12300 10.23500  1.000 110.13892 ? 183 ASN F CG  1 
ATOM   897  O OD1 . ASN A 1 148 ? 191.83600 311.84200 10.22300  1.000 112.16483 ? 183 ASN F OD1 1 
ATOM   898  N ND2 . ASN A 1 148 ? 190.17100 313.31000 10.65000  1.000 100.34289 ? 183 ASN F ND2 1 
ATOM   899  N N   . GLY A 1 149 ? 188.40500 308.92300 11.89900  1.000 96.70655  ? 184 GLY F N   1 
ATOM   900  C CA  . GLY A 1 149 ? 187.96200 308.62500 13.23000  1.000 97.57508  ? 184 GLY F CA  1 
ATOM   901  C C   . GLY A 1 149 ? 186.51200 308.97000 13.47500  1.000 99.28606  ? 184 GLY F C   1 
ATOM   902  O O   . GLY A 1 149 ? 185.65000 308.09000 13.62200  1.000 100.24094 ? 184 GLY F O   1 
ATOM   903  N N   . PRO A 1 150 ? 186.21400 310.26700 13.51500  1.000 92.44098  ? 185 PRO F N   1 
ATOM   904  C CA  . PRO A 1 150 ? 184.92000 310.70700 14.04900  1.000 87.72209  ? 185 PRO F CA  1 
ATOM   905  C C   . PRO A 1 150 ? 183.74600 309.88700 13.51300  1.000 91.51419  ? 185 PRO F C   1 
ATOM   906  O O   . PRO A 1 150 ? 183.78100 309.33200 12.41000  1.000 92.60445  ? 185 PRO F O   1 
ATOM   907  C CB  . PRO A 1 150 ? 184.85300 312.18200 13.63100  1.000 80.99684  ? 185 PRO F CB  1 
ATOM   908  C CG  . PRO A 1 150 ? 186.31500 312.59300 13.51100  1.000 84.22386  ? 185 PRO F CG  1 
ATOM   909  C CD  . PRO A 1 150 ? 187.01000 311.38400 12.96600  1.000 86.63844  ? 185 PRO F CD  1 
ATOM   910  N N   . SER A 1 151 ? 182.71800 309.78100 14.35500  1.000 91.03473  ? 186 SER F N   1 
ATOM   911  C CA  . SER A 1 151 ? 181.51700 308.96400 14.14400  1.000 89.25204  ? 186 SER F CA  1 
ATOM   912  C C   . SER A 1 151 ? 180.41100 309.88000 13.63300  1.000 86.18057  ? 186 SER F C   1 
ATOM   913  O O   . SER A 1 151 ? 179.63000 310.44200 14.40900  1.000 90.38451  ? 186 SER F O   1 
ATOM   914  C CB  . SER A 1 151 ? 181.10000 308.24200 15.42100  1.000 88.66424  ? 186 SER F CB  1 
ATOM   915  O OG  . SER A 1 151 ? 180.64700 309.16200 16.40400  1.000 87.62847  ? 186 SER F OG  1 
ATOM   916  N N   . VAL A 1 152 ? 180.34000 310.05500 12.31200  1.000 80.15278  ? 187 VAL F N   1 
ATOM   917  C CA  . VAL A 1 152 ? 179.40700 311.03900 11.77600  1.000 70.65417  ? 187 VAL F CA  1 
ATOM   918  C C   . VAL A 1 152 ? 178.06900 310.39600 11.44000  1.000 65.79013  ? 187 VAL F C   1 
ATOM   919  O O   . VAL A 1 152 ? 177.96300 309.20600 11.15500  1.000 67.64882  ? 187 VAL F O   1 
ATOM   920  C CB  . VAL A 1 152 ? 180.04700 311.66200 10.52500  1.000 68.68880  ? 187 VAL F CB  1 
ATOM   921  C CG1 . VAL A 1 152 ? 179.80800 310.74400 9.33000   1.000 66.75930  ? 187 VAL F CG1 1 
ATOM   922  C CG2 . VAL A 1 152 ? 179.48600 313.01800 10.26900  1.000 65.40539  ? 187 VAL F CG2 1 
ATOM   923  N N   . LEU A 1 153 ? 177.01800 311.19200 11.46000  1.000 62.82219  ? 188 LEU F N   1 
ATOM   924  C CA  . LEU A 1 153 ? 175.69800 310.69700 11.11300  1.000 58.68332  ? 188 LEU F CA  1 
ATOM   925  C C   . LEU A 1 153 ? 175.39900 311.16300 9.69000   1.000 60.13813  ? 188 LEU F C   1 
ATOM   926  O O   . LEU A 1 153 ? 175.54600 312.35500 9.38700   1.000 61.49882  ? 188 LEU F O   1 
ATOM   927  C CB  . LEU A 1 153 ? 174.66100 311.17700 12.12100  1.000 55.52338  ? 188 LEU F CB  1 
ATOM   928  C CG  . LEU A 1 153 ? 173.23200 310.70100 11.90700  1.000 59.51155  ? 188 LEU F CG  1 
ATOM   929  C CD1 . LEU A 1 153 ? 172.50600 310.73400 13.27300  1.000 56.35542  ? 188 LEU F CD1 1 
ATOM   930  C CD2 . LEU A 1 153 ? 172.48500 311.44100 10.80200  1.000 59.23209  ? 188 LEU F CD2 1 
ATOM   931  N N   . THR A 1 154 ? 175.13000 310.22500 8.78700   1.000 59.93125  ? 189 THR F N   1 
ATOM   932  C CA  . THR A 1 154 ? 174.91400 310.52500 7.38100   1.000 52.66491  ? 189 THR F CA  1 
ATOM   933  C C   . THR A 1 154 ? 173.43600 310.39600 7.03400   1.000 50.60578  ? 189 THR F C   1 
ATOM   934  O O   . THR A 1 154 ? 172.70300 309.61600 7.65600   1.000 55.19827  ? 189 THR F O   1 
ATOM   935  C CB  . THR A 1 154 ? 175.74200 309.60200 6.49000   1.000 54.32364  ? 189 THR F CB  1 
ATOM   936  O OG1 . THR A 1 154 ? 177.09300 309.57900 6.96000   1.000 61.21340  ? 189 THR F OG1 1 
ATOM   937  C CG2 . THR A 1 154 ? 175.73500 310.10300 5.06800   1.000 53.33937  ? 189 THR F CG2 1 
ATOM   938  N N   . SER A 1 155 ? 173.01100 311.16700 6.03200   1.000 50.16265  ? 190 SER F N   1 
ATOM   939  C CA  . SER A 1 155 ? 171.64200 311.10700 5.52400   1.000 51.01588  ? 190 SER F CA  1 
ATOM   940  C C   . SER A 1 155 ? 171.63300 311.19000 3.99700   1.000 46.63304  ? 190 SER F C   1 
ATOM   941  O O   . SER A 1 155 ? 172.47300 311.85700 3.39600   1.000 41.83985  ? 190 SER F O   1 
ATOM   942  C CB  . SER A 1 155 ? 170.77700 312.23500 6.11200   1.000 49.38130  ? 190 SER F CB  1 
ATOM   943  O OG  . SER A 1 155 ? 170.97100 312.36800 7.51400   1.000 51.57143  ? 190 SER F OG  1 
ATOM   944  N N   . LYS A 1 156 ? 170.66800 310.49100 3.38000   1.000 49.12224  ? 191 LYS F N   1 
ATOM   945  C CA  . LYS A 1 156 ? 170.35800 310.53000 1.94100   1.000 49.73311  ? 191 LYS F CA  1 
ATOM   946  C C   . LYS A 1 156 ? 169.05300 311.30700 1.78500   1.000 50.61942  ? 191 LYS F C   1 
ATOM   947  O O   . LYS A 1 156 ? 167.98000 310.76700 2.08400   1.000 51.55297  ? 191 LYS F O   1 
ATOM   948  C CB  . LYS A 1 156 ? 170.19900 309.12500 1.33200   1.000 54.89032  ? 191 LYS F CB  1 
ATOM   949  C CG  . LYS A 1 156 ? 169.87000 309.07900 -0.19900  1.000 53.80370  ? 191 LYS F CG  1 
ATOM   950  C CD  . LYS A 1 156 ? 170.08000 307.70400 -0.87900  1.000 59.16371  ? 191 LYS F CD  1 
ATOM   951  C CE  . LYS A 1 156 ? 171.50300 307.22100 -0.90700  1.000 63.82237  ? 191 LYS F CE  1 
ATOM   952  N NZ  . LYS A 1 156 ? 171.57900 305.91400 -1.62000  1.000 60.17342  ? 191 LYS F NZ  1 
ATOM   953  N N   . VAL A 1 157 ? 169.12700 312.60900 1.47200   1.000 46.17655  ? 192 VAL F N   1 
ATOM   954  C CA  . VAL A 1 157 ? 167.87500 313.38000 1.46500   1.000 49.12102  ? 192 VAL F CA  1 
ATOM   955  C C   . VAL A 1 157 ? 167.13500 313.39100 0.11600   1.000 49.81946  ? 192 VAL F C   1 
ATOM   956  O O   . VAL A 1 157 ? 165.92900 313.69800 0.08100   1.000 43.98562  ? 192 VAL F O   1 
ATOM   957  C CB  . VAL A 1 157 ? 168.12100 314.83500 1.91600   1.000 44.65947  ? 192 VAL F CB  1 
ATOM   958  C CG1 . VAL A 1 157 ? 168.69300 314.87400 3.31000   1.000 46.21043  ? 192 VAL F CG1 1 
ATOM   959  C CG2 . VAL A 1 157 ? 169.08100 315.51700 0.96500   1.000 46.94453  ? 192 VAL F CG2 1 
ATOM   960  N N   . LEU A 1 158 ? 167.80900 313.04600 -0.98500  1.000 47.05479  ? 193 LEU F N   1 
ATOM   961  C CA  . LEU A 1 158 ? 167.22000 313.04900 -2.31800  1.000 41.25000  ? 193 LEU F CA  1 
ATOM   962  C C   . LEU A 1 158 ? 167.89400 311.98100 -3.16300  1.000 44.89834  ? 193 LEU F C   1 
ATOM   963  O O   . LEU A 1 158 ? 169.12300 311.88700 -3.17200  1.000 48.23852  ? 193 LEU F O   1 
ATOM   964  C CB  . LEU A 1 158 ? 167.33300 314.42200 -2.97500  1.000 42.96434  ? 193 LEU F CB  1 
ATOM   965  C CG  . LEU A 1 158 ? 166.63100 314.52000 -4.32600  1.000 47.60327  ? 193 LEU F CG  1 
ATOM   966  C CD1 . LEU A 1 158 ? 165.13500 314.27500 -4.19100  1.000 46.93999  ? 193 LEU F CD1 1 
ATOM   967  C CD2 . LEU A 1 158 ? 166.87900 315.89700 -4.91500  1.000 41.81013  ? 193 LEU F CD2 1 
ATOM   968  N N   . ASP A 1 159 ? 167.11500 311.24800 -3.95200  1.000 45.85978  ? 194 ASP F N   1 
ATOM   969  C CA  . ASP A 1 159 ? 167.69000 310.16500 -4.75000  1.000 49.54019  ? 194 ASP F CA  1 
ATOM   970  C C   . ASP A 1 159 ? 167.37200 310.38000 -6.22100  1.000 47.54410  ? 194 ASP F C   1 
ATOM   971  O O   . ASP A 1 159 ? 166.33400 309.95300 -6.73000  1.000 52.60638  ? 194 ASP F O   1 
ATOM   972  C CB  . ASP A 1 159 ? 167.22200 308.79600 -4.30200  1.000 55.80299  ? 194 ASP F CB  1 
ATOM   973  C CG  . ASP A 1 159 ? 168.10000 307.68400 -4.85600  1.000 62.24062  ? 194 ASP F CG  1 
ATOM   974  O OD1 . ASP A 1 159 ? 168.78800 307.93400 -5.88000  1.000 53.51818  ? 194 ASP F OD1 1 
ATOM   975  O OD2 . ASP A 1 159 ? 168.10100 306.56700 -4.27700  1.000 69.75432  ? 194 ASP F OD2 1 
ATOM   976  N N   . LEU A 1 160 ? 168.28200 311.07200 -6.87800  1.000 42.94683  ? 195 LEU F N   1 
ATOM   977  C CA  . LEU A 1 160 ? 168.22000 311.33600 -8.29600  1.000 43.26102  ? 195 LEU F CA  1 
ATOM   978  C C   . LEU A 1 160 ? 168.84900 310.23700 -9.12000  1.000 50.66866  ? 195 LEU F C   1 
ATOM   979  O O   . LEU A 1 160 ? 168.55200 310.16000 -10.31400 1.000 55.78084  ? 195 LEU F O   1 
ATOM   980  C CB  . LEU A 1 160 ? 168.89600 312.65700 -8.65300  1.000 43.89034  ? 195 LEU F CB  1 
ATOM   981  C CG  . LEU A 1 160 ? 168.07100 313.83900 -8.16200  1.000 44.39941  ? 195 LEU F CG  1 
ATOM   982  C CD1 . LEU A 1 160 ? 168.71900 315.14400 -8.55400  1.000 44.88484  ? 195 LEU F CD1 1 
ATOM   983  C CD2 . LEU A 1 160 ? 166.67700 313.73900 -8.72700  1.000 43.10507  ? 195 LEU F CD2 1 
ATOM   984  N N   . LYS A 1 161 ? 169.79500 309.45700 -8.57200  1.000 52.17190  ? 196 LYS F N   1 
ATOM   985  C CA  . LYS A 1 161 ? 170.33800 308.37500 -9.38900  1.000 54.36477  ? 196 LYS F CA  1 
ATOM   986  C C   . LYS A 1 161 ? 169.26200 307.34700 -9.71700  1.000 56.73163  ? 196 LYS F C   1 
ATOM   987  O O   . LYS A 1 161 ? 169.09200 306.96900 -10.88400 1.000 54.56391  ? 196 LYS F O   1 
ATOM   988  C CB  . LYS A 1 161 ? 171.49000 307.70000 -8.62800  1.000 51.73594  ? 196 LYS F CB  1 
ATOM   989  C CG  . LYS A 1 161 ? 172.21200 306.56000 -9.36800  1.000 58.14243  ? 196 LYS F CG  1 
ATOM   990  C CD  . LYS A 1 161 ? 173.46400 306.00800 -8.62900  1.000 64.63772  ? 196 LYS F CD  1 
ATOM   991  C CE  . LYS A 1 161 ? 173.15800 305.23300 -7.32400  1.000 68.89271  ? 196 LYS F CE  1 
ATOM   992  N NZ  . LYS A 1 161 ? 174.39500 304.91700 -6.49200  1.000 67.08466  ? 196 LYS F NZ  1 
ATOM   993  N N   . ASN A 1 162 ? 168.42400 307.01200 -8.73200  1.000 57.18149  ? 197 ASN F N   1 
ATOM   994  C CA  . ASN A 1 162 ? 167.34000 306.06600 -8.96300  1.000 56.42535  ? 197 ASN F CA  1 
ATOM   995  C C   . ASN A 1 162 ? 166.29500 306.64200 -9.89700  1.000 57.21039  ? 197 ASN F C   1 
ATOM   996  O O   . ASN A 1 162 ? 165.88700 305.98500 -10.86400 1.000 61.72357  ? 197 ASN F O   1 
ATOM   997  C CB  . ASN A 1 162 ? 166.71200 305.63400 -7.64400  1.000 64.48761  ? 197 ASN F CB  1 
ATOM   998  C CG  . ASN A 1 162 ? 167.40300 304.43200 -7.05700  1.000 68.42894  ? 197 ASN F CG  1 
ATOM   999  O OD1 . ASN A 1 162 ? 168.55400 304.13800 -7.40800  1.000 63.48988  ? 197 ASN F OD1 1 
ATOM   1000 N ND2 . ASN A 1 162 ? 166.71800 303.72800 -6.15700  1.000 72.19683  ? 197 ASN F ND2 1 
ATOM   1001 N N   . TYR A 1 163 ? 165.99900 307.93400 -9.74600  1.000 51.09476  ? 198 TYR F N   1 
ATOM   1002 C CA  . TYR A 1 163 ? 164.94000 308.50300 -10.56200 1.000 48.51897  ? 198 TYR F CA  1 
ATOM   1003 C C   . TYR A 1 163 ? 165.39600 308.72500 -11.98500 1.000 50.18957  ? 198 TYR F C   1 
ATOM   1004 O O   . TYR A 1 163 ? 164.67300 308.38600 -12.92300 1.000 53.56231  ? 198 TYR F O   1 
ATOM   1005 C CB  . TYR A 1 163 ? 164.48500 309.83900 -9.96100  1.000 49.15345  ? 198 TYR F CB  1 
ATOM   1006 C CG  . TYR A 1 163 ? 163.25000 310.35200 -10.61200 1.000 44.56297  ? 198 TYR F CG  1 
ATOM   1007 C CD1 . TYR A 1 163 ? 162.00100 309.96200 -10.19100 1.000 47.80606  ? 198 TYR F CD1 1 
ATOM   1008 C CD2 . TYR A 1 163 ? 163.34300 311.15900 -11.72700 1.000 43.80654  ? 198 TYR F CD2 1 
ATOM   1009 C CE1 . TYR A 1 163 ? 160.86400 310.40000 -10.83800 1.000 48.85409  ? 198 TYR F CE1 1 
ATOM   1010 C CE2 . TYR A 1 163 ? 162.22900 311.60300 -12.37900 1.000 45.84569  ? 198 TYR F CE2 1 
ATOM   1011 C CZ  . TYR A 1 163 ? 160.98900 311.21900 -11.93400 1.000 45.33718  ? 198 TYR F CZ  1 
ATOM   1012 O OH  . TYR A 1 163 ? 159.86900 311.65500 -12.58600 1.000 40.91777  ? 198 TYR F OH  1 
ATOM   1013 N N   . ILE A 1 164 ? 166.61000 309.20500 -12.18200 1.000 48.35340  ? 199 ILE F N   1 
ATOM   1014 C CA  . ILE A 1 164 ? 167.03400 309.45300 -13.54500 1.000 50.89386  ? 199 ILE F CA  1 
ATOM   1015 C C   . ILE A 1 164 ? 167.27400 308.13300 -14.25900 1.000 54.08541  ? 199 ILE F C   1 
ATOM   1016 O O   . ILE A 1 164 ? 166.87000 307.96900 -15.41300 1.000 54.14251  ? 199 ILE F O   1 
ATOM   1017 C CB  . ILE A 1 164 ? 168.22900 310.40700 -13.60200 1.000 51.93782  ? 199 ILE F CB  1 
ATOM   1018 C CG1 . ILE A 1 164 ? 167.77000 311.77500 -13.10400 1.000 48.58354  ? 199 ILE F CG1 1 
ATOM   1019 C CG2 . ILE A 1 164 ? 168.74000 310.50900 -15.00900 1.000 51.94010  ? 199 ILE F CG2 1 
ATOM   1020 C CD1 . ILE A 1 164 ? 168.84400 312.80800 -13.09700 1.000 45.50778  ? 199 ILE F CD1 1 
ATOM   1021 N N   . ASP A 1 165 ? 167.91700 307.16200 -13.59600 1.000 57.93894  ? 200 ASP F N   1 
ATOM   1022 C CA  . ASP A 1 165 ? 168.25400 305.91800 -14.28100 1.000 57.79878  ? 200 ASP F CA  1 
ATOM   1023 C C   . ASP A 1 165 ? 167.04700 305.01000 -14.51200 1.000 57.13993  ? 200 ASP F C   1 
ATOM   1024 O O   . ASP A 1 165 ? 167.05400 304.23900 -15.47700 1.000 56.87311  ? 200 ASP F O   1 
ATOM   1025 C CB  . ASP A 1 165 ? 169.32100 305.15800 -13.49400 1.000 56.82948  ? 200 ASP F CB  1 
ATOM   1026 C CG  . ASP A 1 165 ? 170.65200 305.89100 -13.46700 1.000 61.44424  ? 200 ASP F CG  1 
ATOM   1027 O OD1 . ASP A 1 165 ? 170.86600 306.77300 -14.33500 1.000 62.69980  ? 200 ASP F OD1 1 
ATOM   1028 O OD2 . ASP A 1 165 ? 171.48500 305.58000 -12.58700 1.000 61.50332  ? 200 ASP F OD2 1 
ATOM   1029 N N   . LYS A 1 166 ? 165.99200 305.11400 -13.70700 1.000 56.65306  ? 201 LYS F N   1 
ATOM   1030 C CA  . LYS A 1 166 ? 164.81800 304.26200 -13.84800 1.000 53.56451  ? 201 LYS F CA  1 
ATOM   1031 C C   . LYS A 1 166 ? 163.71200 304.90100 -14.68400 1.000 56.63440  ? 201 LYS F C   1 
ATOM   1032 O O   . LYS A 1 166 ? 163.05600 304.20800 -15.46100 1.000 65.46026  ? 201 LYS F O   1 
ATOM   1033 C CB  . LYS A 1 166 ? 164.28800 303.88800 -12.46400 1.000 56.85719  ? 201 LYS F CB  1 
ATOM   1034 C CG  . LYS A 1 166 ? 165.16400 302.85200 -11.71600 1.000 60.58228  ? 201 LYS F CG  1 
ATOM   1035 C CD  . LYS A 1 166 ? 164.53600 302.43300 -10.36400 1.000 62.78784  ? 201 LYS F CD  1 
ATOM   1036 C CE  . LYS A 1 166 ? 163.89300 303.66100 -9.65900  1.000 70.20341  ? 201 LYS F CE  1 
ATOM   1037 N NZ  . LYS A 1 166 ? 163.24900 303.40900 -8.33600  1.000 66.78967  ? 201 LYS F NZ  1 
ATOM   1038 N N   . GLN A 1 167 ? 163.47600 306.20400 -14.55500 1.000 54.00745  ? 202 GLN F N   1 
ATOM   1039 C CA  . GLN A 1 167 ? 162.35600 306.85700 -15.21400 1.000 50.16523  ? 202 GLN F CA  1 
ATOM   1040 C C   . GLN A 1 167 ? 162.76200 307.67800 -16.43100 1.000 57.41499  ? 202 GLN F C   1 
ATOM   1041 O O   . GLN A 1 167 ? 161.90100 307.98900 -17.25700 1.000 62.94300  ? 202 GLN F O   1 
ATOM   1042 C CB  . GLN A 1 167 ? 161.57800 307.74500 -14.23800 1.000 47.79363  ? 202 GLN F CB  1 
ATOM   1043 C CG  . GLN A 1 167 ? 161.53400 307.19900 -12.83800 1.000 54.30872  ? 202 GLN F CG  1 
ATOM   1044 C CD  . GLN A 1 167 ? 160.46800 306.14800 -12.66700 1.000 61.87773  ? 202 GLN F CD  1 
ATOM   1045 O OE1 . GLN A 1 167 ? 159.40500 306.21200 -13.30400 1.000 60.57321  ? 202 GLN F OE1 1 
ATOM   1046 N NE2 . GLN A 1 167 ? 160.75300 305.14900 -11.81800 1.000 60.01227  ? 202 GLN F NE2 1 
ATOM   1047 N N   . LEU A 1 168 ? 164.01700 308.08600 -16.53900 1.000 57.06378  ? 203 LEU F N   1 
ATOM   1048 C CA  . LEU A 1 168 ? 164.48000 308.97400 -17.60600 1.000 57.61994  ? 203 LEU F CA  1 
ATOM   1049 C C   . LEU A 1 168 ? 165.34300 308.29200 -18.67500 1.000 59.29682  ? 203 LEU F C   1 
ATOM   1050 O O   . LEU A 1 168 ? 165.19700 308.62000 -19.84800 1.000 63.06402  ? 203 LEU F O   1 
ATOM   1051 C CB  . LEU A 1 168 ? 165.19000 310.20700 -17.02800 1.000 50.44338  ? 203 LEU F CB  1 
ATOM   1052 C CG  . LEU A 1 168 ? 164.27900 311.07200 -16.13400 1.000 48.17582  ? 203 LEU F CG  1 
ATOM   1053 C CD1 . LEU A 1 168 ? 164.93000 312.40700 -15.75100 1.000 46.08609  ? 203 LEU F CD1 1 
ATOM   1054 C CD2 . LEU A 1 168 ? 162.88500 311.28500 -16.70000 1.000 45.05770  ? 203 LEU F CD2 1 
ATOM   1055 N N   . LEU A 1 169 ? 166.26900 307.38700 -18.33600 1.000 60.42680  ? 204 LEU F N   1 
ATOM   1056 C CA  . LEU A 1 169 ? 167.13100 306.77900 -19.35700 1.000 64.29061  ? 204 LEU F CA  1 
ATOM   1057 C C   . LEU A 1 169 ? 166.38200 305.99300 -20.42400 1.000 67.77712  ? 204 LEU F C   1 
ATOM   1058 O O   . LEU A 1 169 ? 166.74200 306.12200 -21.60700 1.000 69.50356  ? 204 LEU F O   1 
ATOM   1059 C CB  . LEU A 1 169 ? 168.16900 305.83700 -18.73800 1.000 67.36614  ? 204 LEU F CB  1 
ATOM   1060 C CG  . LEU A 1 169 ? 169.34300 306.31300 -17.90700 1.000 66.70058  ? 204 LEU F CG  1 
ATOM   1061 C CD1 . LEU A 1 169 ? 170.21400 305.09800 -17.62800 1.000 62.14346  ? 204 LEU F CD1 1 
ATOM   1062 C CD2 . LEU A 1 169 ? 170.11100 307.38800 -18.66700 1.000 70.62950  ? 204 LEU F CD2 1 
ATOM   1063 N N   . PRO A 1 170 ? 165.35900 305.20300 -20.10800 1.000 67.09597  ? 205 PRO F N   1 
ATOM   1064 C CA  . PRO A 1 170 ? 164.59100 304.55100 -21.17900 1.000 68.28129  ? 205 PRO F CA  1 
ATOM   1065 C C   . PRO A 1 170 ? 163.97700 305.55700 -22.13400 1.000 67.78760  ? 205 PRO F C   1 
ATOM   1066 O O   . PRO A 1 170 ? 163.52100 305.17400 -23.21900 1.000 71.17064  ? 205 PRO F O   1 
ATOM   1067 C CB  . PRO A 1 170 ? 163.50700 303.77800 -20.41300 1.000 65.30605  ? 205 PRO F CB  1 
ATOM   1068 C CG  . PRO A 1 170 ? 164.08300 303.57700 -19.04000 1.000 60.28818  ? 205 PRO F CG  1 
ATOM   1069 C CD  . PRO A 1 170 ? 164.86900 304.82600 -18.77000 1.000 64.47205  ? 205 PRO F CD  1 
ATOM   1070 N N   . ILE A 1 171 ? 163.92900 306.82700 -21.74600 1.000 65.77137  ? 206 ILE F N   1 
ATOM   1071 C CA  . ILE A 1 171 ? 163.38900 307.89300 -22.58200 1.000 65.40963  ? 206 ILE F CA  1 
ATOM   1072 C C   . ILE A 1 171 ? 164.45300 308.49100 -23.50000 1.000 69.77700  ? 206 ILE F C   1 
ATOM   1073 O O   . ILE A 1 171 ? 164.15300 308.88200 -24.63000 1.000 75.70077  ? 206 ILE F O   1 
ATOM   1074 C CB  . ILE A 1 171 ? 162.76600 308.98900 -21.68200 1.000 59.72833  ? 206 ILE F CB  1 
ATOM   1075 C CG1 . ILE A 1 171 ? 161.58400 308.43800 -20.87300 1.000 62.68175  ? 206 ILE F CG1 1 
ATOM   1076 C CG2 . ILE A 1 171 ? 162.47300 310.27100 -22.47600 1.000 51.66290  ? 206 ILE F CG2 1 
ATOM   1077 C CD1 . ILE A 1 171 ? 160.41800 307.90500 -21.73000 1.000 63.36008  ? 206 ILE F CD1 1 
ATOM   1078 N N   . VAL A 1 172 ? 165.70600 308.59300 -23.07100 1.000 66.79125  ? 207 VAL F N   1 
ATOM   1079 C CA  . VAL A 1 172 ? 166.71700 309.27300 -23.87300 1.000 77.02644  ? 207 VAL F CA  1 
ATOM   1080 C C   . VAL A 1 172 ? 167.83000 308.34700 -24.32700 1.000 87.31277  ? 207 VAL F C   1 
ATOM   1081 O O   . VAL A 1 172 ? 168.64300 308.75300 -25.17800 1.000 88.27488  ? 207 VAL F O   1 
ATOM   1082 C CB  . VAL A 1 172 ? 167.30900 310.49500 -23.13300 1.000 79.84112  ? 207 VAL F CB  1 
ATOM   1083 C CG1 . VAL A 1 172 ? 168.45300 311.12000 -23.92800 1.000 91.16635  ? 207 VAL F CG1 1 
ATOM   1084 C CG2 . VAL A 1 172 ? 166.23200 311.53600 -22.89500 1.000 70.85509  ? 207 VAL F CG2 1 
ATOM   1085 N N   . ASN A 1 173 ? 167.88300 307.10800 -23.83500 1.000 87.52308  ? 208 ASN F N   1 
ATOM   1086 C CA  . ASN A 1 173 ? 169.03700 306.29400 -24.17700 1.000 92.74401  ? 208 ASN F CA  1 
ATOM   1087 C C   . ASN A 1 173 ? 168.64700 305.14500 -25.10900 1.000 93.78699  ? 208 ASN F C   1 
ATOM   1088 O O   . ASN A 1 173 ? 168.77400 303.96800 -24.75100 1.000 93.70053  ? 208 ASN F O   1 
ATOM   1089 C CB  . ASN A 1 173 ? 169.68800 305.78200 -22.88200 1.000 92.16404  ? 208 ASN F CB  1 
ATOM   1090 C CG  . ASN A 1 173 ? 171.08900 305.19600 -23.09900 1.000 103.80695 ? 208 ASN F CG  1 
ATOM   1091 O OD1 . ASN A 1 173 ? 171.48700 304.87100 -24.22500 1.000 107.00842 ? 208 ASN F OD1 1 
ATOM   1092 N ND2 . ASN A 1 173 ? 171.85100 305.08000 -22.00700 1.000 94.80363  ? 208 ASN F ND2 1 
ATOM   1093 N N   . LYS A 1 174 ? 168.10700 305.49100 -26.28200 1.000 92.46869  ? 209 LYS F N   1 
ATOM   1094 C CA  . LYS A 1 174 ? 167.72800 304.55100 -27.33100 1.000 94.18343  ? 209 LYS F CA  1 
ATOM   1095 C C   . LYS A 1 174 ? 168.12000 305.17600 -28.65800 1.000 98.36631  ? 209 LYS F C   1 
ATOM   1096 O O   . LYS A 1 174 ? 168.70300 306.26700 -28.70600 1.000 101.91994 ? 209 LYS F O   1 
ATOM   1097 C CB  . LYS A 1 174 ? 166.21500 304.29900 -27.40000 1.000 93.97860  ? 209 LYS F CB  1 
ATOM   1098 C CG  . LYS A 1 174 ? 165.72800 302.87000 -27.31000 1.000 84.21257  ? 209 LYS F CG  1 
ATOM   1099 C CD  . LYS A 1 174 ? 164.21900 302.87400 -27.52600 1.000 73.23341  ? 209 LYS F CD  1 
ATOM   1100 C CE  . LYS A 1 174 ? 163.49100 303.57800 -26.39900 1.000 63.57154  ? 209 LYS F CE  1 
ATOM   1101 N NZ  . LYS A 1 174 ? 163.62000 302.85500 -25.11200 1.000 58.24362  ? 209 LYS F NZ  1 
ATOM   1102 N N   . GLN A 1 175 ? 167.75800 304.49800 -29.75000 1.000 96.71380  ? 210 GLN F N   1 
ATOM   1103 C CA  . GLN A 1 175 ? 167.96300 305.09100 -31.06900 1.000 102.41720 ? 210 GLN F CA  1 
ATOM   1104 C C   . GLN A 1 175 ? 166.96300 306.23600 -31.23600 1.000 101.62624 ? 210 GLN F C   1 
ATOM   1105 O O   . GLN A 1 175 ? 167.33100 307.35400 -31.61900 1.000 101.86628 ? 210 GLN F O   1 
ATOM   1106 C CB  . GLN A 1 175 ? 167.88900 304.05100 -32.19500 1.000 107.36332 ? 210 GLN F CB  1 
ATOM   1107 C CG  . GLN A 1 175 ? 169.28200 303.87500 -32.88100 1.000 111.14478 ? 210 GLN F CG  1 
ATOM   1108 C CD  . GLN A 1 175 ? 169.31500 302.88200 -34.04200 1.000 108.21356 ? 210 GLN F CD  1 
ATOM   1109 O OE1 . GLN A 1 175 ? 168.49400 302.95600 -34.95800 1.000 109.14678 ? 210 GLN F OE1 1 
ATOM   1110 N NE2 . GLN A 1 175 ? 170.28300 301.96000 -34.01400 1.000 93.94361  ? 210 GLN F NE2 1 
ATOM   1111 N N   . SER A 1 176 ? 165.67800 305.94800 -30.98500 1.000 100.94098 ? 211 SER F N   1 
ATOM   1112 C CA  . SER A 1 176 ? 164.61300 306.94500 -30.93400 1.000 97.44014  ? 211 SER F CA  1 
ATOM   1113 C C   . SER A 1 176 ? 164.05500 307.01800 -29.50600 1.000 91.07578  ? 211 SER F C   1 
ATOM   1114 O O   . SER A 1 176 ? 163.98500 306.01300 -28.78300 1.000 86.56858  ? 211 SER F O   1 
ATOM   1115 C CB  . SER A 1 176 ? 163.50000 306.62500 -31.95100 1.000 93.23310  ? 211 SER F CB  1 
ATOM   1116 O OG  . SER A 1 176 ? 162.93100 305.33600 -31.75800 1.000 82.53191  ? 211 SER F OG  1 
ATOM   1117 N N   . CYS A 1 177 ? 163.71700 308.23100 -29.08800 1.000 88.98546  ? 212 CYS F N   1 
ATOM   1118 C CA  . CYS A 1 177 ? 163.26800 308.49000 -27.72400 1.000 84.38444  ? 212 CYS F CA  1 
ATOM   1119 C C   . CYS A 1 177 ? 161.92200 307.83400 -27.39100 1.000 71.27391  ? 212 CYS F C   1 
ATOM   1120 O O   . CYS A 1 177 ? 160.98400 307.87200 -28.19100 1.000 70.52515  ? 212 CYS F O   1 
ATOM   1121 C CB  . CYS A 1 177 ? 163.13600 310.01000 -27.51600 1.000 86.29094  ? 212 CYS F CB  1 
ATOM   1122 S SG  . CYS A 1 177 ? 164.43500 311.14200 -28.24300 1.000 123.77534 ? 212 CYS F SG  1 
ATOM   1123 N N   . SER A 1 178 ? 161.81400 307.22200 -26.21200 1.000 62.76781  ? 213 SER F N   1 
ATOM   1124 C CA  . SER A 1 178 ? 160.46000 306.85900 -25.83100 1.000 57.73967  ? 213 SER F CA  1 
ATOM   1125 C C   . SER A 1 178 ? 159.71900 308.11100 -25.31800 1.000 53.30808  ? 213 SER F C   1 
ATOM   1126 O O   . SER A 1 178 ? 160.32700 309.08100 -24.87100 1.000 56.54154  ? 213 SER F O   1 
ATOM   1127 C CB  . SER A 1 178 ? 160.48500 305.75700 -24.77200 1.000 55.40720  ? 213 SER F CB  1 
ATOM   1128 O OG  . SER A 1 178 ? 159.17000 305.33400 -24.47100 1.000 65.00256  ? 213 SER F OG  1 
ATOM   1129 N N   . ILE A 1 179 ? 158.39300 308.09000 -25.39700 1.000 47.73471  ? 214 ILE F N   1 
ATOM   1130 C CA  . ILE A 1 179 ? 157.54900 309.22700 -25.04900 1.000 44.05982  ? 214 ILE F CA  1 
ATOM   1131 C C   . ILE A 1 179 ? 157.16900 309.17000 -23.56400 1.000 43.38738  ? 214 ILE F C   1 
ATOM   1132 O O   . ILE A 1 179 ? 156.55200 308.17800 -23.14700 1.000 46.82378  ? 214 ILE F O   1 
ATOM   1133 C CB  . ILE A 1 179 ? 156.32200 309.39400 -25.94200 1.000 45.06833  ? 214 ILE F CB  1 
ATOM   1134 C CG1 . ILE A 1 179 ? 156.75000 309.51800 -27.40500 1.000 46.91267  ? 214 ILE F CG1 1 
ATOM   1135 C CG2 . ILE A 1 179 ? 155.67200 310.71100 -25.61100 1.000 41.00494  ? 214 ILE F CG2 1 
ATOM   1136 C CD1 . ILE A 1 179 ? 157.72300 310.59600 -27.64200 1.000 40.51851  ? 214 ILE F CD1 1 
ATOM   1137 N N   . PRO A 1 180 ? 157.58000 310.12900 -22.74700 1.000 42.07287  ? 215 PRO F N   1 
ATOM   1138 C CA  . PRO A 1 180 ? 157.15800 310.16600 -21.34000 1.000 38.01811  ? 215 PRO F CA  1 
ATOM   1139 C C   . PRO A 1 180 ? 155.80000 310.81200 -21.11400 1.000 37.11550  ? 215 PRO F C   1 
ATOM   1140 O O   . PRO A 1 180 ? 155.35100 311.66500 -21.88400 1.000 38.44766  ? 215 PRO F O   1 
ATOM   1141 C CB  . PRO A 1 180 ? 158.22300 311.05100 -20.69400 1.000 38.60978  ? 215 PRO F CB  1 
ATOM   1142 C CG  . PRO A 1 180 ? 158.56600 312.01300 -21.75900 1.000 38.95695  ? 215 PRO F CG  1 
ATOM   1143 C CD  . PRO A 1 180 ? 158.43300 311.28100 -23.08100 1.000 43.98974  ? 215 PRO F CD  1 
ATOM   1144 N N   . ASN A 1 181 ? 155.12300 310.35700 -20.05400 1.000 36.83945  ? 216 ASN F N   1 
ATOM   1145 C CA  . ASN A 1 181 ? 153.81900 310.91500 -19.69300 1.000 34.57984  ? 216 ASN F CA  1 
ATOM   1146 C C   . ASN A 1 181 ? 154.01200 312.29100 -19.04800 1.000 32.66455  ? 216 ASN F C   1 
ATOM   1147 O O   . ASN A 1 181 ? 155.07400 312.60800 -18.51400 1.000 34.64097  ? 216 ASN F O   1 
ATOM   1148 C CB  . ASN A 1 181 ? 153.07700 309.96700 -18.75000 1.000 38.09850  ? 216 ASN F CB  1 
ATOM   1149 C CG  . ASN A 1 181 ? 153.96200 309.45100 -17.60900 1.000 36.95871  ? 216 ASN F CG  1 
ATOM   1150 O OD1 . ASN A 1 181 ? 155.11800 309.08200 -17.82400 1.000 39.78277  ? 216 ASN F OD1 1 
ATOM   1151 N ND2 . ASN A 1 181 ? 153.41400 309.40700 -16.40200 1.000 33.95026  ? 216 ASN F ND2 1 
ATOM   1152 N N   . ILE A 1 182 ? 152.96700 313.12100 -19.09800 1.000 33.02544  ? 217 ILE F N   1 
ATOM   1153 C CA  . ILE A 1 182 ? 153.08100 314.48000 -18.56100 1.000 32.71916  ? 217 ILE F CA  1 
ATOM   1154 C C   . ILE A 1 182 ? 153.28400 314.55700 -17.04900 1.000 34.31184  ? 217 ILE F C   1 
ATOM   1155 O O   . ILE A 1 182 ? 153.96400 315.48600 -16.54900 1.000 34.26538  ? 217 ILE F O   1 
ATOM   1156 C CB  . ILE A 1 182 ? 151.81200 315.24900 -18.95500 1.000 29.95379  ? 217 ILE F CB  1 
ATOM   1157 C CG1 . ILE A 1 182 ? 152.07000 316.75400 -18.90800 1.000 33.87918  ? 217 ILE F CG1 1 
ATOM   1158 C CG2 . ILE A 1 182 ? 150.67700 314.82800 -18.03300 1.000 27.51855  ? 217 ILE F CG2 1 
ATOM   1159 C CD1 . ILE A 1 182 ? 153.15500 317.20100 -19.88000 1.000 30.69227  ? 217 ILE F CD1 1 
ATOM   1160 N N   . GLU A 1 183 ? 152.84800 313.52100 -16.33000 1.000 34.83572  ? 218 GLU F N   1 
ATOM   1161 C CA  . GLU A 1 183 ? 153.09100 313.44100 -14.89800 1.000 32.59992  ? 218 GLU F CA  1 
ATOM   1162 C C   . GLU A 1 183 ? 154.58400 313.32900 -14.62600 1.000 34.11122  ? 218 GLU F C   1 
ATOM   1163 O O   . GLU A 1 183 ? 155.08700 313.88100 -13.64400 1.000 36.50270  ? 218 GLU F O   1 
ATOM   1164 C CB  . GLU A 1 183 ? 152.34700 312.25400 -14.30000 1.000 31.97412  ? 218 GLU F CB  1 
ATOM   1165 C CG  . GLU A 1 183 ? 150.83200 312.33400 -14.30300 1.000 35.23389  ? 218 GLU F CG  1 
ATOM   1166 C CD  . GLU A 1 183 ? 150.18700 311.87700 -15.65900 1.000 40.19506  ? 218 GLU F CD  1 
ATOM   1167 O OE1 . GLU A 1 183 ? 150.91500 311.49200 -16.62300 1.000 36.83832  ? 218 GLU F OE1 1 
ATOM   1168 O OE2 . GLU A 1 183 ? 148.93400 311.82400 -15.72500 1.000 43.31937  ? 218 GLU F OE2 1 
ATOM   1169 N N   . THR A 1 184 ? 155.30600 312.61600 -15.49200 1.000 31.95877  ? 219 THR F N   1 
ATOM   1170 C CA  . THR A 1 184 ? 156.74400 312.47900 -15.35400 1.000 29.19859  ? 219 THR F CA  1 
ATOM   1171 C C   . THR A 1 184 ? 157.45000 313.81100 -15.57300 1.000 34.54156  ? 219 THR F C   1 
ATOM   1172 O O   . THR A 1 184 ? 158.41300 314.12900 -14.86700 1.000 37.87758  ? 219 THR F O   1 
ATOM   1173 C CB  . THR A 1 184 ? 157.22200 311.42800 -16.32700 1.000 30.36248  ? 219 THR F CB  1 
ATOM   1174 O OG1 . THR A 1 184 ? 156.62700 310.17900 -15.96700 1.000 34.24467  ? 219 THR F OG1 1 
ATOM   1175 C CG2 . THR A 1 184 ? 158.74500 311.34200 -16.35500 1.000 33.26701  ? 219 THR F CG2 1 
ATOM   1176 N N   . VAL A 1 185 ? 156.99700 314.61100 -16.53500 1.000 32.51311  ? 220 VAL F N   1 
ATOM   1177 C CA  . VAL A 1 185 ? 157.63400 315.90100 -16.73100 1.000 31.38864  ? 220 VAL F CA  1 
ATOM   1178 C C   . VAL A 1 185 ? 157.50500 316.73000 -15.46700 1.000 33.71588  ? 220 VAL F C   1 
ATOM   1179 O O   . VAL A 1 185 ? 158.50300 317.25000 -14.93300 1.000 35.07670  ? 220 VAL F O   1 
ATOM   1180 C CB  . VAL A 1 185 ? 156.99500 316.61900 -17.92400 1.000 30.19710  ? 220 VAL F CB  1 
ATOM   1181 C CG1 . VAL A 1 185 ? 157.57300 318.01900 -18.11200 1.000 28.00325  ? 220 VAL F CG1 1 
ATOM   1182 C CG2 . VAL A 1 185 ? 157.24500 315.81200 -19.12300 1.000 38.28126  ? 220 VAL F CG2 1 
ATOM   1183 N N   . ILE A 1 186 ? 156.32700 316.68100 -14.85500 1.000 32.55853  ? 221 ILE F N   1 
ATOM   1184 C CA  . ILE A 1 186 ? 156.12100 317.48500 -13.66100 1.000 31.45042  ? 221 ILE F CA  1 
ATOM   1185 C C   . ILE A 1 186 ? 156.87700 316.91000 -12.47200 1.000 33.99444  ? 221 ILE F C   1 
ATOM   1186 O O   . ILE A 1 186 ? 157.48400 317.65900 -11.69500 1.000 37.52709  ? 221 ILE F O   1 
ATOM   1187 C CB  . ILE A 1 186 ? 154.61600 317.62000 -13.41400 1.000 26.81340  ? 221 ILE F CB  1 
ATOM   1188 C CG1 . ILE A 1 186 ? 154.03600 318.47500 -14.54700 1.000 23.80374  ? 221 ILE F CG1 1 
ATOM   1189 C CG2 . ILE A 1 186 ? 154.31500 318.12000 -12.00500 1.000 28.10885  ? 221 ILE F CG2 1 
ATOM   1190 C CD1 . ILE A 1 186 ? 152.56300 318.69800 -14.45000 1.000 27.92831  ? 221 ILE F CD1 1 
ATOM   1191 N N   . GLU A 1 187 ? 156.88400 315.59000 -12.31300 1.000 36.14607  ? 222 GLU F N   1 
ATOM   1192 C CA  . GLU A 1 187 ? 157.60600 315.00500 -11.19000 1.000 38.91977  ? 222 GLU F CA  1 
ATOM   1193 C C   . GLU A 1 187 ? 159.10100 315.27500 -11.29000 1.000 38.75761  ? 222 GLU F C   1 
ATOM   1194 O O   . GLU A 1 187 ? 159.77000 315.49400 -10.27100 1.000 38.96473  ? 222 GLU F O   1 
ATOM   1195 C CB  . GLU A 1 187 ? 157.45000 313.48500 -11.15200 1.000 41.08395  ? 222 GLU F CB  1 
ATOM   1196 C CG  . GLU A 1 187 ? 157.74400 312.89400 -9.78500  1.000 44.96316  ? 222 GLU F CG  1 
ATOM   1197 C CD  . GLU A 1 187 ? 157.41100 311.42500 -9.69700  1.000 57.21300  ? 222 GLU F CD  1 
ATOM   1198 O OE1 . GLU A 1 187 ? 157.27900 310.78500 -10.76800 1.000 58.04153  ? 222 GLU F OE1 1 
ATOM   1199 O OE2 . GLU A 1 187 ? 157.24800 310.91500 -8.56400  1.000 62.11921  ? 222 GLU F OE2 1 
ATOM   1200 N N   . PHE A 1 188 ? 159.63500 315.35400 -12.50700 1.000 40.58394  ? 223 PHE F N   1 
ATOM   1201 C CA  . PHE A 1 188 ? 161.05800 315.63100 -12.58900 1.000 39.73845  ? 223 PHE F CA  1 
ATOM   1202 C C   . PHE A 1 188 ? 161.34800 317.10000 -12.33700 1.000 39.56257  ? 223 PHE F C   1 
ATOM   1203 O O   . PHE A 1 188 ? 162.33300 317.41200 -11.67000 1.000 38.33560  ? 223 PHE F O   1 
ATOM   1204 C CB  . PHE A 1 188 ? 161.59800 315.18200 -13.93900 1.000 34.95728  ? 223 PHE F CB  1 
ATOM   1205 C CG  . PHE A 1 188 ? 163.06300 315.33500 -14.07600 1.000 35.04954  ? 223 PHE F CG  1 
ATOM   1206 C CD1 . PHE A 1 188 ? 163.90400 314.87800 -13.09500 1.000 33.85341  ? 223 PHE F CD1 1 
ATOM   1207 C CD2 . PHE A 1 188 ? 163.61200 315.88000 -15.20900 1.000 34.75697  ? 223 PHE F CD2 1 
ATOM   1208 C CE1 . PHE A 1 188 ? 165.27400 314.99300 -13.24200 1.000 36.69020  ? 223 PHE F CE1 1 
ATOM   1209 C CE2 . PHE A 1 188 ? 164.97100 316.00000 -15.34200 1.000 35.78937  ? 223 PHE F CE2 1 
ATOM   1210 C CZ  . PHE A 1 188 ? 165.79900 315.55000 -14.36300 1.000 33.56874  ? 223 PHE F CZ  1 
ATOM   1211 N N   . GLN A 1 189 ? 160.45800 318.01600 -12.72200 1.000 40.05423  ? 224 GLN F N   1 
ATOM   1212 C CA  . GLN A 1 189 ? 160.76800 319.38900 -12.33300 1.000 42.43539  ? 224 GLN F CA  1 
ATOM   1213 C C   . GLN A 1 189 ? 160.67500 319.57600 -10.82200 1.000 39.12739  ? 224 GLN F C   1 
ATOM   1214 O O   . GLN A 1 189 ? 161.56100 320.21000 -10.23500 1.000 40.36659  ? 224 GLN F O   1 
ATOM   1215 C CB  . GLN A 1 189 ? 159.86200 320.36100 -13.08700 1.000 42.51938  ? 224 GLN F CB  1 
ATOM   1216 C CG  . GLN A 1 189 ? 160.24000 320.34300 -14.55200 1.000 50.09959  ? 224 GLN F CG  1 
ATOM   1217 C CD  . GLN A 1 189 ? 159.33100 321.14800 -15.48900 1.000 57.07895  ? 224 GLN F CD  1 
ATOM   1218 O OE1 . GLN A 1 189 ? 158.26500 321.67500 -15.09100 1.000 54.55369  ? 224 GLN F OE1 1 
ATOM   1219 N NE2 . GLN A 1 189 ? 159.79000 321.28800 -16.74900 1.000 52.37872  ? 224 GLN F NE2 1 
ATOM   1220 N N   . GLN A 1 190 ? 159.78900 318.83100 -10.15700 1.000 40.69259  ? 225 GLN F N   1 
ATOM   1221 C CA  . GLN A 1 190 ? 159.70500 318.94900 -8.70300  1.000 42.06968  ? 225 GLN F CA  1 
ATOM   1222 C C   . GLN A 1 190 ? 160.92100 318.34500 -8.00800  1.000 43.00548  ? 225 GLN F C   1 
ATOM   1223 O O   . GLN A 1 190 ? 161.51500 318.99100 -7.13700  1.000 49.31122  ? 225 GLN F O   1 
ATOM   1224 C CB  . GLN A 1 190 ? 158.42200 318.30100 -8.16900  1.000 40.01057  ? 225 GLN F CB  1 
ATOM   1225 C CG  . GLN A 1 190 ? 157.15100 318.92000 -8.69600  1.000 41.52354  ? 225 GLN F CG  1 
ATOM   1226 C CD  . GLN A 1 190 ? 156.94500 320.33100 -8.20200  1.000 51.22425  ? 225 GLN F CD  1 
ATOM   1227 O OE1 . GLN A 1 190 ? 157.02900 321.29600 -8.96900  1.000 54.31753  ? 225 GLN F OE1 1 
ATOM   1228 N NE2 . GLN A 1 190 ? 156.61700 320.46100 -6.92300  1.000 58.03619  ? 225 GLN F NE2 1 
ATOM   1229 N N   . LYS A 1 191 ? 161.37300 317.15900 -8.43000  1.000 40.24518  ? 226 LYS F N   1 
ATOM   1230 C CA  . LYS A 1 191 ? 162.51900 316.56900 -7.74500  1.000 37.22215  ? 226 LYS F CA  1 
ATOM   1231 C C   . LYS A 1 191 ? 163.80200 317.33300 -8.02800  1.000 39.56225  ? 226 LYS F C   1 
ATOM   1232 O O   . LYS A 1 191 ? 164.56500 317.62800 -7.10200  1.000 44.49040  ? 226 LYS F O   1 
ATOM   1233 C CB  . LYS A 1 191 ? 162.70200 315.09200 -8.11100  1.000 38.74628  ? 226 LYS F CB  1 
ATOM   1234 C CG  . LYS A 1 191 ? 161.74000 314.15000 -7.39100  1.000 45.09374  ? 226 LYS F CG  1 
ATOM   1235 C CD  . LYS A 1 191 ? 162.25600 312.69500 -7.40700  1.000 47.83244  ? 226 LYS F CD  1 
ATOM   1236 C CE  . LYS A 1 191 ? 161.44400 311.78900 -6.46100  1.000 54.85693  ? 226 LYS F CE  1 
ATOM   1237 N NZ  . LYS A 1 191 ? 162.27900 310.69800 -5.83900  1.000 58.22388  ? 226 LYS F NZ  1 
ATOM   1238 N N   . ASN A 1 192 ? 164.00900 317.75400 -9.26600  1.000 39.49985  ? 227 ASN F N   1 
ATOM   1239 C CA  . ASN A 1 192 ? 165.24100 318.43500 -9.62300  1.000 38.38429  ? 227 ASN F CA  1 
ATOM   1240 C C   . ASN A 1 192 ? 165.29800 319.82300 -8.99000  1.000 43.25416  ? 227 ASN F C   1 
ATOM   1241 O O   . ASN A 1 192 ? 166.39000 320.41800 -8.88500  1.000 43.94150  ? 227 ASN F O   1 
ATOM   1242 C CB  . ASN A 1 192 ? 165.31200 318.55300 -11.14500 1.000 37.98928  ? 227 ASN F CB  1 
ATOM   1243 C CG  . ASN A 1 192 ? 166.67700 318.97000 -11.64500 1.000 41.04620  ? 227 ASN F CG  1 
ATOM   1244 O OD1 . ASN A 1 192 ? 167.67800 318.63100 -11.04400 1.000 44.70966  ? 227 ASN F OD1 1 
ATOM   1245 N ND2 . ASN A 1 192 ? 166.72100 319.72500 -12.73600 1.000 41.33163  ? 227 ASN F ND2 1 
ATOM   1246 N N   . ASN A 1 193 ? 164.15500 320.33100 -8.51700  1.000 41.70179  ? 228 ASN F N   1 
ATOM   1247 C CA  . ASN A 1 193 ? 164.13900 321.69900 -8.02200  1.000 45.03050  ? 228 ASN F CA  1 
ATOM   1248 C C   . ASN A 1 193 ? 165.08100 321.87300 -6.82100  1.000 42.73032  ? 228 ASN F C   1 
ATOM   1249 O O   . ASN A 1 193 ? 165.80900 322.87100 -6.73800  1.000 41.83151  ? 228 ASN F O   1 
ATOM   1250 C CB  . ASN A 1 193 ? 162.71000 322.06900 -7.60200  1.000 41.13704  ? 228 ASN F CB  1 
ATOM   1251 C CG  . ASN A 1 193 ? 162.60400 323.48600 -7.10900  1.000 44.13771  ? 228 ASN F CG  1 
ATOM   1252 O OD1 . ASN A 1 193 ? 163.13300 324.40300 -7.73800  1.000 46.75260  ? 228 ASN F OD1 1 
ATOM   1253 N ND2 . ASN A 1 193 ? 162.06600 323.65800 -5.90300  1.000 44.66052  ? 228 ASN F ND2 1 
ATOM   1254 N N   . ARG A 1 194 ? 165.06900 320.93800 -5.86900  1.000 39.46542  ? 229 ARG F N   1 
ATOM   1255 C CA  . ARG A 1 194 ? 165.92000 321.12200 -4.70100  1.000 35.97131  ? 229 ARG F CA  1 
ATOM   1256 C C   . ARG A 1 194 ? 167.39500 321.12500 -5.06500  1.000 38.81213  ? 229 ARG F C   1 
ATOM   1257 O O   . ARG A 1 194 ? 168.16500 321.94900 -4.55700  1.000 38.65478  ? 229 ARG F O   1 
ATOM   1258 C CB  . ARG A 1 194 ? 165.64900 320.02500 -3.68200  1.000 38.44352  ? 229 ARG F CB  1 
ATOM   1259 C CG  . ARG A 1 194 ? 166.34200 320.23900 -2.36800  1.000 40.99693  ? 229 ARG F CG  1 
ATOM   1260 C CD  . ARG A 1 194 ? 165.97900 319.16300 -1.34900  1.000 44.36569  ? 229 ARG F CD  1 
ATOM   1261 N NE  . ARG A 1 194 ? 166.57900 319.42700 -0.04300  1.000 46.74904  ? 229 ARG F NE  1 
ATOM   1262 C CZ  . ARG A 1 194 ? 166.43400 318.66500 1.03400   1.000 46.15883  ? 229 ARG F CZ  1 
ATOM   1263 N NH1 . ARG A 1 194 ? 165.70800 317.56100 1.00700   1.000 45.01569  ? 229 ARG F NH1 1 
ATOM   1264 N NH2 . ARG A 1 194 ? 167.04000 319.01900 2.16700   1.000 46.59455  ? 229 ARG F NH2 1 
ATOM   1265 N N   . LEU A 1 195 ? 167.78000 320.32500 -6.05400  1.000 39.48651  ? 230 LEU F N   1 
ATOM   1266 C CA  . LEU A 1 195 ? 169.17300 320.35000 -6.47600  1.000 37.25875  ? 230 LEU F CA  1 
ATOM   1267 C C   . LEU A 1 195 ? 169.51300 321.70500 -7.05100  1.000 36.99745  ? 230 LEU F C   1 
ATOM   1268 O O   . LEU A 1 195 ? 170.61300 322.21900 -6.84100  1.000 42.63261  ? 230 LEU F O   1 
ATOM   1269 C CB  . LEU A 1 195 ? 169.45000 319.25300 -7.49300  1.000 37.61893  ? 230 LEU F CB  1 
ATOM   1270 C CG  . LEU A 1 195 ? 170.87200 319.33900 -8.01500  1.000 36.45769  ? 230 LEU F CG  1 
ATOM   1271 C CD1 . LEU A 1 195 ? 171.77600 319.13500 -6.85400  1.000 38.00545  ? 230 LEU F CD1 1 
ATOM   1272 C CD2 . LEU A 1 195 ? 171.12600 318.32300 -9.07200  1.000 35.46051  ? 230 LEU F CD2 1 
ATOM   1273 N N   . LEU A 1 196 ? 168.61700 322.25600 -7.86000  1.000 40.69239  ? 231 LEU F N   1 
ATOM   1274 C CA  . LEU A 1 196 ? 168.90100 323.55200 -8.46600  1.000 40.91403  ? 231 LEU F CA  1 
ATOM   1275 C C   . LEU A 1 196 ? 168.97300 324.65900 -7.42000  1.000 43.06607  ? 231 LEU F C   1 
ATOM   1276 O O   . LEU A 1 196 ? 169.81400 325.55400 -7.51300  1.000 42.46098  ? 231 LEU F O   1 
ATOM   1277 C CB  . LEU A 1 196 ? 167.82500 323.88200 -9.48700  1.000 39.01765  ? 231 LEU F CB  1 
ATOM   1278 C CG  . LEU A 1 196 ? 167.70700 322.75600 -10.47900 1.000 43.99951  ? 231 LEU F CG  1 
ATOM   1279 C CD1 . LEU A 1 196 ? 166.71100 323.14900 -11.53700 1.000 44.61311  ? 231 LEU F CD1 1 
ATOM   1280 C CD2 . LEU A 1 196 ? 169.11200 322.54800 -11.08200 1.000 42.76607  ? 231 LEU F CD2 1 
ATOM   1281 N N   . GLU A 1 197 ? 168.11600 324.61300 -6.40200  1.000 42.45476  ? 232 GLU F N   1 
ATOM   1282 C CA  . GLU A 1 197 ? 168.17400 325.68800 -5.42100  1.000 46.60486  ? 232 GLU F CA  1 
ATOM   1283 C C   . GLU A 1 197 ? 169.41800 325.57400 -4.55900  1.000 44.78862  ? 232 GLU F C   1 
ATOM   1284 O O   . GLU A 1 197 ? 169.99100 326.59300 -4.15000  1.000 48.07141  ? 232 GLU F O   1 
ATOM   1285 C CB  . GLU A 1 197 ? 166.92500 325.73700 -4.55800  1.000 46.77555  ? 232 GLU F CB  1 
ATOM   1286 C CG  . GLU A 1 197 ? 165.71200 325.99800 -5.39200  1.000 46.23050  ? 232 GLU F CG  1 
ATOM   1287 C CD  . GLU A 1 197 ? 165.62000 327.43400 -5.90100  1.000 53.50973  ? 232 GLU F CD  1 
ATOM   1288 O OE1 . GLU A 1 197 ? 166.43300 328.29800 -5.48900  1.000 50.04306  ? 232 GLU F OE1 1 
ATOM   1289 O OE2 . GLU A 1 197 ? 164.73900 327.67800 -6.75900  1.000 63.10145  ? 232 GLU F OE2 1 
ATOM   1290 N N   . ILE A 1 198 ? 169.87400 324.35300 -4.30300  1.000 44.11251  ? 233 ILE F N   1 
ATOM   1291 C CA  . ILE A 1 198 ? 171.08800 324.20900 -3.52300  1.000 41.38906  ? 233 ILE F CA  1 
ATOM   1292 C C   . ILE A 1 198 ? 172.27600 324.69200 -4.34100  1.000 43.42208  ? 233 ILE F C   1 
ATOM   1293 O O   . ILE A 1 198 ? 173.16600 325.37300 -3.82100  1.000 46.22517  ? 233 ILE F O   1 
ATOM   1294 C CB  . ILE A 1 198 ? 171.26100 322.75400 -3.09000  1.000 37.80255  ? 233 ILE F CB  1 
ATOM   1295 C CG1 . ILE A 1 198 ? 170.20800 322.40300 -2.06300  1.000 42.27965  ? 233 ILE F CG1 1 
ATOM   1296 C CG2 . ILE A 1 198 ? 172.62400 322.55200 -2.51300  1.000 36.31336  ? 233 ILE F CG2 1 
ATOM   1297 C CD1 . ILE A 1 198 ? 170.24900 320.97100 -1.65400  1.000 43.26087  ? 233 ILE F CD1 1 
ATOM   1298 N N   . THR A 1 199 ? 172.31000 324.37000 -5.63300  1.000 41.24870  ? 234 THR F N   1 
ATOM   1299 C CA  . THR A 1 199 ? 173.39300 324.91200 -6.43700  1.000 45.13302  ? 234 THR F CA  1 
ATOM   1300 C C   . THR A 1 199 ? 173.32100 326.43600 -6.50300  1.000 45.61078  ? 234 THR F C   1 
ATOM   1301 O O   . THR A 1 199 ? 174.35400 327.10300 -6.43500  1.000 49.67923  ? 234 THR F O   1 
ATOM   1302 C CB  . THR A 1 199 ? 173.35300 324.29800 -7.86400  1.000 42.20290  ? 234 THR F CB  1 
ATOM   1303 O OG1 . THR A 1 199 ? 173.77400 322.93300 -7.82400  1.000 41.97065  ? 234 THR F OG1 1 
ATOM   1304 C CG2 . THR A 1 199 ? 174.25000 325.01400 -8.84200  1.000 35.65216  ? 234 THR F CG2 1 
ATOM   1305 N N   . ARG A 1 200 ? 172.12200 327.01200 -6.48800  1.000 46.48728  ? 235 ARG F N   1 
ATOM   1306 C CA  . ARG A 1 200 ? 172.01300 328.46700 -6.55700  1.000 48.52751  ? 235 ARG F CA  1 
ATOM   1307 C C   . ARG A 1 200 ? 172.59400 329.12200 -5.30900  1.000 50.16782  ? 235 ARG F C   1 
ATOM   1308 O O   . ARG A 1 200 ? 173.43500 330.03900 -5.40700  1.000 50.02671  ? 235 ARG F O   1 
ATOM   1309 C CB  . ARG A 1 200 ? 170.55600 328.84500 -6.80300  1.000 47.58017  ? 235 ARG F CB  1 
ATOM   1310 C CG  . ARG A 1 200 ? 170.33200 330.20500 -7.39200  1.000 48.02994  ? 235 ARG F CG  1 
ATOM   1311 C CD  . ARG A 1 200 ? 168.84100 330.47400 -7.78200  1.000 54.92964  ? 235 ARG F CD  1 
ATOM   1312 N NE  . ARG A 1 200 ? 168.24900 329.38400 -8.57600  1.000 62.13605  ? 235 ARG F NE  1 
ATOM   1313 C CZ  . ARG A 1 200 ? 168.18300 329.31100 -9.91200  1.000 63.79236  ? 235 ARG F CZ  1 
ATOM   1314 N NH1 . ARG A 1 200 ? 168.68100 330.26100 -10.69600 1.000 61.36249  ? 235 ARG F NH1 1 
ATOM   1315 N NH2 . ARG A 1 200 ? 167.59600 328.25200 -10.47600 1.000 52.79451  ? 235 ARG F NH2 1 
ATOM   1316 N N   . GLU A 1 201 ? 172.25100 328.58000 -4.12500  1.000 47.77752  ? 236 GLU F N   1 
ATOM   1317 C CA  . GLU A 1 201 ? 172.77100 329.17500 -2.89800  1.000 45.94893  ? 236 GLU F CA  1 
ATOM   1318 C C   . GLU A 1 201 ? 174.26900 328.95700 -2.78200  1.000 54.88983  ? 236 GLU F C   1 
ATOM   1319 O O   . GLU A 1 201 ? 175.00400 329.87700 -2.41200  1.000 57.04632  ? 236 GLU F O   1 
ATOM   1320 C CB  . GLU A 1 201 ? 172.11200 328.58800 -1.64000  1.000 40.56703  ? 236 GLU F CB  1 
ATOM   1321 C CG  . GLU A 1 201 ? 170.63200 328.66800 -1.51600  1.000 40.54889  ? 236 GLU F CG  1 
ATOM   1322 C CD  . GLU A 1 201 ? 170.12200 328.10900 -0.17700  1.000 46.76244  ? 236 GLU F CD  1 
ATOM   1323 O OE1 . GLU A 1 201 ? 170.91000 327.93000 0.77900   1.000 53.73400  ? 236 GLU F OE1 1 
ATOM   1324 O OE2 . GLU A 1 201 ? 168.89800 327.91500 -0.04900  1.000 48.11424  ? 236 GLU F OE2 1 
ATOM   1325 N N   . PHE A 1 202 ? 174.74700 327.75900 -3.11900  1.000 56.33403  ? 237 PHE F N   1 
ATOM   1326 C CA  . PHE A 1 202 ? 176.17000 327.49700 -2.96600  1.000 53.55568  ? 237 PHE F CA  1 
ATOM   1327 C C   . PHE A 1 202 ? 176.97700 328.31900 -3.97400  1.000 48.04274  ? 237 PHE F C   1 
ATOM   1328 O O   . PHE A 1 202 ? 178.09600 328.74600 -3.67700  1.000 52.52602  ? 237 PHE F O   1 
ATOM   1329 C CB  . PHE A 1 202 ? 176.44000 325.98700 -3.08100  1.000 50.15638  ? 237 PHE F CB  1 
ATOM   1330 C CG  . PHE A 1 202 ? 176.24200 325.21700 -1.76400  1.000 44.90072  ? 237 PHE F CG  1 
ATOM   1331 C CD1 . PHE A 1 202 ? 176.43600 325.82200 -0.53500  1.000 43.73370  ? 237 PHE F CD1 1 
ATOM   1332 C CD2 . PHE A 1 202 ? 175.85000 323.86800 -1.77300  1.000 46.82279  ? 237 PHE F CD2 1 
ATOM   1333 C CE1 . PHE A 1 202 ? 176.24900 325.08200 0.66500   1.000 45.15072  ? 237 PHE F CE1 1 
ATOM   1334 C CE2 . PHE A 1 202 ? 175.65300 323.12400 -0.57900  1.000 38.71276  ? 237 PHE F CE2 1 
ATOM   1335 C CZ  . PHE A 1 202 ? 175.85700 323.72500 0.63200   1.000 39.21077  ? 237 PHE F CZ  1 
ATOM   1336 N N   . SER A 1 203 ? 176.39700 328.65800 -5.11600  1.000 43.19974  ? 238 SER F N   1 
ATOM   1337 C CA  . SER A 1 203 ? 177.17400 329.42400 -6.07900  1.000 46.75660  ? 238 SER F CA  1 
ATOM   1338 C C   . SER A 1 203 ? 177.30600 330.87800 -5.61900  1.000 53.15252  ? 238 SER F C   1 
ATOM   1339 O O   . SER A 1 203 ? 178.35600 331.49600 -5.83800  1.000 54.65580  ? 238 SER F O   1 
ATOM   1340 C CB  . SER A 1 203 ? 176.57800 329.28200 -7.48700  1.000 45.95106  ? 238 SER F CB  1 
ATOM   1341 O OG  . SER A 1 203 ? 175.39100 330.02200 -7.64700  1.000 56.81186  ? 238 SER F OG  1 
ATOM   1342 N N   . VAL A 1 204 ? 176.22700 331.49700 -5.12200  1.000 55.48334  ? 239 VAL F N   1 
ATOM   1343 C CA  . VAL A 1 204 ? 176.37500 332.90300 -4.70400  1.000 50.39402  ? 239 VAL F CA  1 
ATOM   1344 C C   . VAL A 1 204 ? 177.12500 333.08000 -3.36200  1.000 51.46438  ? 239 VAL F C   1 
ATOM   1345 O O   . VAL A 1 204 ? 177.59000 334.19200 -3.07600  1.000 50.74229  ? 239 VAL F O   1 
ATOM   1346 C CB  . VAL A 1 204 ? 175.04700 333.65900 -4.60200  1.000 49.83514  ? 239 VAL F CB  1 
ATOM   1347 C CG1 . VAL A 1 204 ? 174.33300 333.63300 -5.94900  1.000 52.86240  ? 239 VAL F CG1 1 
ATOM   1348 C CG2 . VAL A 1 204 ? 174.19800 333.07200 -3.46300  1.000 43.41055  ? 239 VAL F CG2 1 
ATOM   1349 N N   . ASN A 1 205 ? 177.25000 332.04000 -2.52200  1.000 46.63241  ? 240 ASN F N   1 
ATOM   1350 C CA  . ASN A 1 205 ? 177.86600 332.16400 -1.20200  1.000 44.61630  ? 240 ASN F CA  1 
ATOM   1351 C C   . ASN A 1 205 ? 179.17500 331.41200 -1.06800  1.000 43.62645  ? 240 ASN F C   1 
ATOM   1352 O O   . ASN A 1 205 ? 179.59100 331.11400 0.05100   1.000 45.90354  ? 240 ASN F O   1 
ATOM   1353 C CB  . ASN A 1 205 ? 176.92400 331.69400 -0.07900  1.000 46.16974  ? 240 ASN F CB  1 
ATOM   1354 C CG  . ASN A 1 205 ? 175.65300 332.55900 0.08200   1.000 48.21025  ? 240 ASN F CG  1 
ATOM   1355 O OD1 . ASN A 1 205 ? 174.54700 332.04500 0.18100   1.000 47.72132  ? 240 ASN F OD1 1 
ATOM   1356 N ND2 . ASN A 1 205 ? 175.84400 333.85400 0.27800   1.000 49.69738  ? 240 ASN F ND2 1 
ATOM   1357 N N   . ALA A 1 206 ? 179.79900 331.03500 -2.17100  1.000 40.94545  ? 241 ALA F N   1 
ATOM   1358 C CA  . ALA A 1 206 ? 181.12600 330.43300 -2.12000  1.000 46.26677  ? 241 ALA F CA  1 
ATOM   1359 C C   . ALA A 1 206 ? 181.18100 329.19400 -1.21800  1.000 49.59274  ? 241 ALA F C   1 
ATOM   1360 O O   . ALA A 1 206 ? 182.15600 328.98500 -0.49200  1.000 47.09282  ? 241 ALA F O   1 
ATOM   1361 C CB  . ALA A 1 206 ? 182.16400 331.46100 -1.68000  1.000 44.80282  ? 241 ALA F CB  1 
ATOM   1362 N N   . GLY A 1 207 ? 180.14800 328.34700 -1.27900  1.000 48.60905  ? 242 GLY F N   1 
ATOM   1363 C CA  . GLY A 1 207 ? 180.13000 327.08100 -0.55900  1.000 44.72666  ? 242 GLY F CA  1 
ATOM   1364 C C   . GLY A 1 207 ? 179.78400 327.10100 0.92000   1.000 42.82558  ? 242 GLY F C   1 
ATOM   1365 O O   . GLY A 1 207 ? 179.71100 326.03000 1.53100   1.000 42.47982  ? 242 GLY F O   1 
ATOM   1366 N N   . VAL A 1 208 ? 179.64700 328.25800 1.55100   1.000 49.09028  ? 243 VAL F N   1 
ATOM   1367 C CA  . VAL A 1 208 ? 179.31400 328.33200 2.97300   1.000 43.84628  ? 243 VAL F CA  1 
ATOM   1368 C C   . VAL A 1 208 ? 178.09000 329.20100 3.22400   1.000 39.50877  ? 243 VAL F C   1 
ATOM   1369 O O   . VAL A 1 208 ? 178.13200 330.40800 2.96900   1.000 47.15099  ? 243 VAL F O   1 
ATOM   1370 C CB  . VAL A 1 208 ? 180.49400 328.81400 3.80800   1.000 44.01821  ? 243 VAL F CB  1 
ATOM   1371 C CG1 . VAL A 1 208 ? 180.12500 328.74000 5.27100   1.000 43.19787  ? 243 VAL F CG1 1 
ATOM   1372 C CG2 . VAL A 1 208 ? 181.69700 327.93300 3.50900   1.000 40.76260  ? 243 VAL F CG2 1 
ATOM   1373 N N   . THR A 1 209 ? 176.98400 328.59600 3.62400   1.000 37.20368  ? 244 THR F N   1 
ATOM   1374 C CA  . THR A 1 209 ? 175.75500 329.34800 3.84400   1.000 44.27601  ? 244 THR F CA  1 
ATOM   1375 C C   . THR A 1 209 ? 175.38300 329.33200 5.32400   1.000 42.87358  ? 244 THR F C   1 
ATOM   1376 O O   . THR A 1 209 ? 175.74700 328.41100 6.05700   1.000 39.38785  ? 244 THR F O   1 
ATOM   1377 C CB  . THR A 1 209 ? 174.53100 328.80800 3.05900   1.000 46.36904  ? 244 THR F CB  1 
ATOM   1378 O OG1 . THR A 1 209 ? 174.12700 327.50200 3.52800   1.000 36.45520  ? 244 THR F OG1 1 
ATOM   1379 C CG2 . THR A 1 209 ? 174.78900 328.77100 1.56400   1.000 49.26996  ? 244 THR F CG2 1 
ATOM   1380 N N   . THR A 1 210 ? 174.84900 330.45300 5.79700   1.000 44.94495  ? 245 THR F N   1 
ATOM   1381 C CA  . THR A 1 210 ? 174.30000 330.54900 7.14700   1.000 40.27109  ? 245 THR F CA  1 
ATOM   1382 C C   . THR A 1 210 ? 173.34900 331.73800 7.10700   1.000 37.86522  ? 245 THR F C   1 
ATOM   1383 O O   . THR A 1 210 ? 173.75000 332.81700 6.65700   1.000 38.66902  ? 245 THR F O   1 
ATOM   1384 C CB  . THR A 1 210 ? 175.39000 330.74400 8.21100   1.000 42.99659  ? 245 THR F CB  1 
ATOM   1385 O OG1 . THR A 1 210 ? 174.79000 330.99400 9.49900   1.000 41.27204  ? 245 THR F OG1 1 
ATOM   1386 C CG2 . THR A 1 210 ? 176.29100 331.92600 7.83400   1.000 36.91471  ? 245 THR F CG2 1 
ATOM   1387 N N   . PRO A 1 211 ? 172.11100 331.61000 7.60000   1.000 38.13214  ? 246 PRO F N   1 
ATOM   1388 C CA  . PRO A 1 211 ? 171.60800 330.37900 8.21500   1.000 39.87281  ? 246 PRO F CA  1 
ATOM   1389 C C   . PRO A 1 211 ? 171.42200 329.25800 7.18900   1.000 41.66449  ? 246 PRO F C   1 
ATOM   1390 O O   . PRO A 1 211 ? 171.60300 329.40100 5.97700   1.000 41.75401  ? 246 PRO F O   1 
ATOM   1391 C CB  . PRO A 1 211 ? 170.23200 330.79200 8.78000   1.000 36.04874  ? 246 PRO F CB  1 
ATOM   1392 C CG  . PRO A 1 211 ? 170.24500 332.27400 8.79900   1.000 38.13653  ? 246 PRO F CG  1 
ATOM   1393 C CD  . PRO A 1 211 ? 171.09900 332.67600 7.63500   1.000 37.28175  ? 246 PRO F CD  1 
ATOM   1394 N N   . VAL A 1 212 ? 171.14700 328.08800 7.73300   1.000 37.97077  ? 247 VAL F N   1 
ATOM   1395 C CA  . VAL A 1 212 ? 170.91400 326.89400 6.94200   1.000 37.32589  ? 247 VAL F CA  1 
ATOM   1396 C C   . VAL A 1 212 ? 169.44600 326.90200 6.52000   1.000 38.51974  ? 247 VAL F C   1 
ATOM   1397 O O   . VAL A 1 212 ? 168.55500 326.96200 7.37700   1.000 37.92507  ? 247 VAL F O   1 
ATOM   1398 C CB  . VAL A 1 212 ? 171.29700 325.63800 7.73500   1.000 35.48656  ? 247 VAL F CB  1 
ATOM   1399 C CG1 . VAL A 1 212 ? 170.98700 324.37000 6.92700   1.000 36.22193  ? 247 VAL F CG1 1 
ATOM   1400 C CG2 . VAL A 1 212 ? 172.74900 325.71700 8.13200   1.000 32.95596  ? 247 VAL F CG2 1 
ATOM   1401 N N   . SER A 1 213 ? 169.19800 326.99500 5.20500   1.000 43.23979  ? 248 SER F N   1 
ATOM   1402 C CA  . SER A 1 213 ? 167.85200 327.08300 4.62300   1.000 43.40204  ? 248 SER F CA  1 
ATOM   1403 C C   . SER A 1 213 ? 167.09500 325.73900 4.60800   1.000 46.89030  ? 248 SER F C   1 
ATOM   1404 O O   . SER A 1 213 ? 167.65600 324.65100 4.81800   1.000 45.23218  ? 248 SER F O   1 
ATOM   1405 C CB  . SER A 1 213 ? 167.93600 327.58700 3.19500   1.000 44.49751  ? 248 SER F CB  1 
ATOM   1406 O OG  . SER A 1 213 ? 168.67900 326.67200 2.42300   1.000 42.39873  ? 248 SER F OG  1 
ATOM   1407 N N   . THR A 1 214 ? 165.78300 325.82300 4.32700   1.000 45.35477  ? 249 THR F N   1 
ATOM   1408 C CA  . THR A 1 214 ? 165.00400 324.59100 4.21200   1.000 47.72268  ? 249 THR F CA  1 
ATOM   1409 C C   . THR A 1 214 ? 165.40000 323.76400 2.99600   1.000 49.14187  ? 249 THR F C   1 
ATOM   1410 O O   . THR A 1 214 ? 165.17700 322.54800 2.99900   1.000 52.26939  ? 249 THR F O   1 
ATOM   1411 C CB  . THR A 1 214 ? 163.50300 324.90200 4.22900   1.000 50.29664  ? 249 THR F CB  1 
ATOM   1412 O OG1 . THR A 1 214 ? 163.18700 325.79100 3.15300   1.000 59.17664  ? 249 THR F OG1 1 
ATOM   1413 C CG2 . THR A 1 214 ? 163.08000 325.54200 5.56200   1.000 46.20416  ? 249 THR F CG2 1 
ATOM   1414 N N   . TYR A 1 215 ? 166.01900 324.38400 1.98500   1.000 45.37017  ? 250 TYR F N   1 
ATOM   1415 C CA  . TYR A 1 215 ? 166.58300 323.63800 0.86200   1.000 42.95862  ? 250 TYR F CA  1 
ATOM   1416 C C   . TYR A 1 215 ? 167.78900 322.82400 1.27300   1.000 47.06535  ? 250 TYR F C   1 
ATOM   1417 O O   . TYR A 1 215 ? 167.98000 321.70900 0.78500   1.000 50.75412  ? 250 TYR F O   1 
ATOM   1418 C CB  . TYR A 1 215 ? 166.94700 324.57400 -0.28300  1.000 42.78192  ? 250 TYR F CB  1 
ATOM   1419 C CG  . TYR A 1 215 ? 165.78100 325.15800 -1.03000  1.000 46.13674  ? 250 TYR F CG  1 
ATOM   1420 C CD1 . TYR A 1 215 ? 164.63200 324.39700 -1.24100  1.000 47.95401  ? 250 TYR F CD1 1 
ATOM   1421 C CD2 . TYR A 1 215 ? 165.79200 326.46300 -1.47600  1.000 49.48180  ? 250 TYR F CD2 1 
ATOM   1422 C CE1 . TYR A 1 215 ? 163.55000 324.89700 -1.94200  1.000 51.25160  ? 250 TYR F CE1 1 
ATOM   1423 C CE2 . TYR A 1 215 ? 164.69300 326.99500 -2.16700  1.000 55.36945  ? 250 TYR F CE2 1 
ATOM   1424 C CZ  . TYR A 1 215 ? 163.57200 326.20800 -2.39600  1.000 54.79576  ? 250 TYR F CZ  1 
ATOM   1425 O OH  . TYR A 1 215 ? 162.49000 326.72600 -3.09500  1.000 57.38486  ? 250 TYR F OH  1 
ATOM   1426 N N   . MET A 1 216 ? 168.66600 323.40400 2.09600   1.000 52.08605  ? 251 MET F N   1 
ATOM   1427 C CA  . MET A 1 216 ? 169.80000 322.65100 2.62200   1.000 44.67728  ? 251 MET F CA  1 
ATOM   1428 C C   . MET A 1 216 ? 169.32800 321.57100 3.58600   1.000 43.75881  ? 251 MET F C   1 
ATOM   1429 O O   . MET A 1 216 ? 169.90800 320.48200 3.62800   1.000 42.36850  ? 251 MET F O   1 
ATOM   1430 C CB  . MET A 1 216 ? 170.77100 323.58100 3.33300   1.000 42.81535  ? 251 MET F CB  1 
ATOM   1431 C CG  . MET A 1 216 ? 171.38600 324.53100 2.39900   1.000 44.00876  ? 251 MET F CG  1 
ATOM   1432 S SD  . MET A 1 216 ? 172.58100 323.75400 1.36200   1.000 34.43840  ? 251 MET F SD  1 
ATOM   1433 C CE  . MET A 1 216 ? 172.94200 325.13300 0.27600   1.000 41.50823  ? 251 MET F CE  1 
ATOM   1434 N N   . LEU A 1 217 ? 168.32600 321.88400 4.41700   1.000 42.26004  ? 252 LEU F N   1 
ATOM   1435 C CA  . LEU A 1 217 ? 167.84800 320.94100 5.42300   1.000 45.24649  ? 252 LEU F CA  1 
ATOM   1436 C C   . LEU A 1 217 ? 166.39100 321.23100 5.79100   1.000 47.53170  ? 252 LEU F C   1 
ATOM   1437 O O   . LEU A 1 217 ? 166.06900 322.30500 6.30800   1.000 48.08555  ? 252 LEU F O   1 
ATOM   1438 C CB  . LEU A 1 217 ? 168.75900 320.95900 6.64100   1.000 47.81702  ? 252 LEU F CB  1 
ATOM   1439 C CG  . LEU A 1 217 ? 168.66200 319.77900 7.59300   1.000 47.48044  ? 252 LEU F CG  1 
ATOM   1440 C CD1 . LEU A 1 217 ? 169.02900 318.46900 6.91400   1.000 40.97790  ? 252 LEU F CD1 1 
ATOM   1441 C CD2 . LEU A 1 217 ? 169.57300 320.05400 8.75000   1.000 45.54934  ? 252 LEU F CD2 1 
ATOM   1442 N N   . THR A 1 218 ? 165.50000 320.29500 5.49200   1.000 51.07412  ? 253 THR F N   1 
ATOM   1443 C CA  . THR A 1 218 ? 164.08200 320.46700 5.77300   1.000 51.57015  ? 253 THR F CA  1 
ATOM   1444 C C   . THR A 1 218 ? 163.79400 320.50500 7.26800   1.000 47.23486  ? 253 THR F C   1 
ATOM   1445 O O   . THR A 1 218 ? 164.52000 319.92500 8.07000   1.000 47.64187  ? 253 THR F O   1 
ATOM   1446 C CB  . THR A 1 218 ? 163.34600 319.25600 5.19300   1.000 49.75054  ? 253 THR F CB  1 
ATOM   1447 O OG1 . THR A 1 218 ? 163.18600 319.42000 3.78800   1.000 46.65330  ? 253 THR F OG1 1 
ATOM   1448 C CG2 . THR A 1 218 ? 161.98900 319.03400 5.86000   1.000 54.74269  ? 253 THR F CG2 1 
ATOM   1449 N N   . ASN A 1 219 ? 162.70300 321.17600 7.64600   1.000 44.53629  ? 254 ASN F N   1 
ATOM   1450 C CA  . ASN A 1 219 ? 162.32000 321.14600 9.05000   1.000 42.38241  ? 254 ASN F CA  1 
ATOM   1451 C C   . ASN A 1 219 ? 162.09200 319.72700 9.52400   1.000 46.44174  ? 254 ASN F C   1 
ATOM   1452 O O   . ASN A 1 219 ? 162.41800 319.38100 10.66500  1.000 47.54561  ? 254 ASN F O   1 
ATOM   1453 C CB  . ASN A 1 219 ? 161.09100 321.99500 9.32100   1.000 44.74350  ? 254 ASN F CB  1 
ATOM   1454 C CG  . ASN A 1 219 ? 161.37000 323.45700 9.19700   1.000 47.88934  ? 254 ASN F CG  1 
ATOM   1455 O OD1 . ASN A 1 219 ? 162.37300 323.86600 8.62900   1.000 50.59505  ? 254 ASN F OD1 1 
ATOM   1456 N ND2 . ASN A 1 219 ? 160.51900 324.26500 9.81200   1.000 48.95572  ? 254 ASN F ND2 1 
ATOM   1457 N N   . SER A 1 220 ? 161.51000 318.89600 8.67000   1.000 48.21553  ? 255 SER F N   1 
ATOM   1458 C CA  . SER A 1 220 ? 161.36500 317.49900 9.03200   1.000 49.61461  ? 255 SER F CA  1 
ATOM   1459 C C   . SER A 1 220 ? 162.73900 316.86200 9.16900   1.000 49.27532  ? 255 SER F C   1 
ATOM   1460 O O   . SER A 1 220 ? 163.00100 316.12700 10.13400  1.000 49.70005  ? 255 SER F O   1 
ATOM   1461 C CB  . SER A 1 220 ? 160.49400 316.77600 8.00300   1.000 57.15634  ? 255 SER F CB  1 
ATOM   1462 O OG  . SER A 1 220 ? 159.14600 317.23400 8.08700   1.000 60.41658  ? 255 SER F OG  1 
ATOM   1463 N N   . GLU A 1 221 ? 163.66000 317.18600 8.24800   1.000 46.72549  ? 256 GLU F N   1 
ATOM   1464 C CA  . GLU A 1 221 ? 164.99200 316.60400 8.36900   1.000 50.14878  ? 256 GLU F CA  1 
ATOM   1465 C C   . GLU A 1 221 ? 165.75900 317.18500 9.55000   1.000 48.61012  ? 256 GLU F C   1 
ATOM   1466 O O   . GLU A 1 221 ? 166.46300 316.44800 10.24700  1.000 44.98623  ? 256 GLU F O   1 
ATOM   1467 C CB  . GLU A 1 221 ? 165.76900 316.81000 7.07200   1.000 43.74886  ? 256 GLU F CB  1 
ATOM   1468 C CG  . GLU A 1 221 ? 165.05300 316.31800 5.84300   1.000 48.75809  ? 256 GLU F CG  1 
ATOM   1469 C CD  . GLU A 1 221 ? 165.72100 316.79600 4.55500   1.000 52.26636  ? 256 GLU F CD  1 
ATOM   1470 O OE1 . GLU A 1 221 ? 166.59300 317.68100 4.65100   1.000 51.52802  ? 256 GLU F OE1 1 
ATOM   1471 O OE2 . GLU A 1 221 ? 165.45600 316.22400 3.46600   1.000 52.17341  ? 256 GLU F OE2 1 
ATOM   1472 N N   . LEU A 1 222 ? 165.55000 318.46300 9.86500   1.000 46.44329  ? 257 LEU F N   1 
ATOM   1473 C CA  . LEU A 1 222 ? 166.25900 319.04700 10.98900  1.000 41.12946  ? 257 LEU F CA  1 
ATOM   1474 C C   . LEU A 1 222 ? 165.75500 318.45900 12.28500  1.000 43.61965  ? 257 LEU F C   1 
ATOM   1475 O O   . LEU A 1 222 ? 166.53800 318.21300 13.20100  1.000 44.11629  ? 257 LEU F O   1 
ATOM   1476 C CB  . LEU A 1 222 ? 166.13200 320.55500 10.99600  1.000 39.38270  ? 257 LEU F CB  1 
ATOM   1477 C CG  . LEU A 1 222 ? 166.81400 321.18400 12.20800  1.000 38.72214  ? 257 LEU F CG  1 
ATOM   1478 C CD1 . LEU A 1 222 ? 168.26500 320.85800 12.27800  1.000 33.82252  ? 257 LEU F CD1 1 
ATOM   1479 C CD2 . LEU A 1 222 ? 166.61700 322.68000 12.09000  1.000 39.03845  ? 257 LEU F CD2 1 
ATOM   1480 N N   . LEU A 1 223 ? 164.43600 318.33700 12.42500  1.000 43.19533  ? 258 LEU F N   1 
ATOM   1481 C CA  . LEU A 1 223 ? 163.88200 317.76100 13.63500  1.000 42.37513  ? 258 LEU F CA  1 
ATOM   1482 C C   . LEU A 1 223 ? 164.27800 316.30600 13.81000  1.000 50.97710  ? 258 LEU F C   1 
ATOM   1483 O O   . LEU A 1 223 ? 164.56600 315.88300 14.93600  1.000 57.86595  ? 258 LEU F O   1 
ATOM   1484 C CB  . LEU A 1 223 ? 162.37200 317.90100 13.61900  1.000 40.87020  ? 258 LEU F CB  1 
ATOM   1485 C CG  . LEU A 1 223 ? 161.94100 319.34200 13.78000  1.000 43.34503  ? 258 LEU F CG  1 
ATOM   1486 C CD1 . LEU A 1 223 ? 160.44100 319.48400 13.59400  1.000 50.89893  ? 258 LEU F CD1 1 
ATOM   1487 C CD2 . LEU A 1 223 ? 162.37300 319.80100 15.18900  1.000 40.53023  ? 258 LEU F CD2 1 
ATOM   1488 N N   . SER A 1 224 ? 164.28500 315.50900 12.72100  1.000 50.97348  ? 259 SER F N   1 
ATOM   1489 C CA  . SER A 1 224 ? 164.75700 314.12400 12.85300  1.000 52.81637  ? 259 SER F CA  1 
ATOM   1490 C C   . SER A 1 224 ? 166.24200 314.07500 13.18000  1.000 52.53389  ? 259 SER F C   1 
ATOM   1491 O O   . SER A 1 224 ? 166.68800 313.17600 13.90200  1.000 52.85089  ? 259 SER F O   1 
ATOM   1492 C CB  . SER A 1 224 ? 164.46000 313.28400 11.60400  1.000 52.65911  ? 259 SER F CB  1 
ATOM   1493 O OG  . SER A 1 224 ? 165.37700 313.53000 10.55400  1.000 59.43926  ? 259 SER F OG  1 
ATOM   1494 N N   . LEU A 1 225 ? 167.01100 315.04500 12.67900  1.000 48.60303  ? 260 LEU F N   1 
ATOM   1495 C CA  . LEU A 1 225 ? 168.42900 315.09500 12.97700  1.000 44.46043  ? 260 LEU F CA  1 
ATOM   1496 C C   . LEU A 1 225 ? 168.65000 315.50200 14.42600  1.000 51.74305  ? 260 LEU F C   1 
ATOM   1497 O O   . LEU A 1 225 ? 169.61900 315.05100 15.04900  1.000 56.25933  ? 260 LEU F O   1 
ATOM   1498 C CB  . LEU A 1 225 ? 169.10100 316.05400 12.01300  1.000 38.59600  ? 260 LEU F CB  1 
ATOM   1499 C CG  . LEU A 1 225 ? 170.60500 316.13300 12.09300  1.000 40.00316  ? 260 LEU F CG  1 
ATOM   1500 C CD1 . LEU A 1 225 ? 171.17000 314.75200 12.08600  1.000 48.47732  ? 260 LEU F CD1 1 
ATOM   1501 C CD2 . LEU A 1 225 ? 171.09300 316.89400 10.89600  1.000 40.20469  ? 260 LEU F CD2 1 
ATOM   1502 N N   . ILE A 1 226 ? 167.79700 316.38100 14.96400  1.000 47.22524  ? 261 ILE F N   1 
ATOM   1503 C CA  . ILE A 1 226 ? 167.90200 316.73200 16.37700  1.000 48.11744  ? 261 ILE F CA  1 
ATOM   1504 C C   . ILE A 1 226 ? 167.56700 315.51100 17.22600  1.000 54.94226  ? 261 ILE F C   1 
ATOM   1505 O O   . ILE A 1 226 ? 168.24900 315.21200 18.21700  1.000 54.87418  ? 261 ILE F O   1 
ATOM   1506 C CB  . ILE A 1 226 ? 166.99100 317.93000 16.71900  1.000 46.25566  ? 261 ILE F CB  1 
ATOM   1507 C CG1 . ILE A 1 226 ? 167.48700 319.21100 16.04900  1.000 40.83177  ? 261 ILE F CG1 1 
ATOM   1508 C CG2 . ILE A 1 226 ? 166.84300 318.11600 18.22000  1.000 44.14667  ? 261 ILE F CG2 1 
ATOM   1509 C CD1 . ILE A 1 226 ? 166.83100 320.42000 16.60200  1.000 35.64155  ? 261 ILE F CD1 1 
ATOM   1510 N N   . ASN A 1 227 ? 166.52400 314.76700 16.83300  1.000 59.38461  ? 262 ASN F N   1 
ATOM   1511 C CA  . ASN A 1 227 ? 166.09400 313.62800 17.63900  1.000 57.84915  ? 262 ASN F CA  1 
ATOM   1512 C C   . ASN A 1 227 ? 167.15700 312.53600 17.66700  1.000 60.88485  ? 262 ASN F C   1 
ATOM   1513 O O   . ASN A 1 227 ? 167.23200 311.76400 18.63500  1.000 59.59776  ? 262 ASN F O   1 
ATOM   1514 C CB  . ASN A 1 227 ? 164.78000 313.05600 17.12700  1.000 53.14947  ? 262 ASN F CB  1 
ATOM   1515 C CG  . ASN A 1 227 ? 164.06400 312.25700 18.18900  1.000 63.71209  ? 262 ASN F CG  1 
ATOM   1516 O OD1 . ASN A 1 227 ? 164.68600 311.80400 19.15400  1.000 69.88609  ? 262 ASN F OD1 1 
ATOM   1517 N ND2 . ASN A 1 227 ? 162.75300 312.08900 18.03600  1.000 66.52765  ? 262 ASN F ND2 1 
ATOM   1518 N N   . ASP A 1 228 ? 167.98100 312.45600 16.61900  1.000 61.69101  ? 263 ASP F N   1 
ATOM   1519 C CA  . ASP A 1 228 ? 168.96900 311.39800 16.50000  1.000 62.15040  ? 263 ASP F CA  1 
ATOM   1520 C C   . ASP A 1 228 ? 170.31800 311.82800 17.04700  1.000 63.42266  ? 263 ASP F C   1 
ATOM   1521 O O   . ASP A 1 228 ? 171.32200 311.14900 16.80500  1.000 67.04074  ? 263 ASP F O   1 
ATOM   1522 C CB  . ASP A 1 228 ? 169.15200 311.03200 15.02600  1.000 62.11097  ? 263 ASP F CB  1 
ATOM   1523 C CG  . ASP A 1 228 ? 168.17400 309.97000 14.54700  1.000 73.19778  ? 263 ASP F CG  1 
ATOM   1524 O OD1 . ASP A 1 228 ? 167.27200 309.53200 15.31400  1.000 72.63577  ? 263 ASP F OD1 1 
ATOM   1525 O OD2 . ASP A 1 228 ? 168.30600 309.58400 13.37000  1.000 72.78680  ? 263 ASP F OD2 1 
ATOM   1526 N N   . MET A 1 229 ? 170.36900 312.94100 17.69900  1.000 58.82374  ? 264 MET F N   1 
ATOM   1527 C CA  . MET A 1 229 ? 171.65100 313.41900 18.17500  1.000 55.44867  ? 264 MET F CA  1 
ATOM   1528 C C   . MET A 1 229 ? 171.98100 312.81200 19.53200  1.000 59.89416  ? 264 MET F C   1 
ATOM   1529 O O   . MET A 1 229 ? 171.08500 312.50300 20.32600  1.000 62.50727  ? 264 MET F O   1 
ATOM   1530 C CB  . MET A 1 229 ? 171.74100 314.94700 18.28000  1.000 65.30609  ? 264 MET F CB  1 
ATOM   1531 C CG  . MET A 1 229 ? 171.87800 315.72600 16.96300  1.000 63.20482  ? 264 MET F CG  1 
ATOM   1532 S SD  . MET A 1 229 ? 172.25700 317.48100 17.29900  1.000 59.28475  ? 264 MET F SD  1 
ATOM   1533 C CE  . MET A 1 229 ? 170.64000 318.27200 17.17800  1.000 51.31884  ? 264 MET F CE  1 
ATOM   1534 N N   . PRO A 1 230 ? 173.23800 312.64900 19.79600  1.000 60.01284  ? 265 PRO F N   1 
ATOM   1535 C CA  . PRO A 1 230 ? 173.72800 312.17800 21.10300  1.000 58.24693  ? 265 PRO F CA  1 
ATOM   1536 C C   . PRO A 1 230 ? 173.69700 313.29100 22.14500  1.000 60.63536  ? 265 PRO F C   1 
ATOM   1537 O O   . PRO A 1 230 ? 174.73900 313.73700 22.63500  1.000 62.60612  ? 265 PRO F O   1 
ATOM   1538 C CB  . PRO A 1 230 ? 175.14800 311.70500 20.76500  1.000 62.77626  ? 265 PRO F CB  1 
ATOM   1539 C CG  . PRO A 1 230 ? 175.56700 312.58600 19.64500  1.000 63.27443  ? 265 PRO F CG  1 
ATOM   1540 C CD  . PRO A 1 230 ? 174.32800 312.82400 18.82000  1.000 64.37260  ? 265 PRO F CD  1 
ATOM   1541 N N   . ILE A 1 231 ? 172.48700 313.80400 22.41900  1.000 60.72743  ? 266 ILE F N   1 
ATOM   1542 C CA  . ILE A 1 231 ? 172.25800 314.87300 23.39000  1.000 61.62067  ? 266 ILE F CA  1 
ATOM   1543 C C   . ILE A 1 231 ? 171.16800 314.42500 24.35400  1.000 61.48083  ? 266 ILE F C   1 
ATOM   1544 O O   . ILE A 1 231 ? 170.46100 313.44500 24.11300  1.000 59.96107  ? 266 ILE F O   1 
ATOM   1545 C CB  . ILE A 1 231 ? 171.78200 316.19500 22.76100  1.000 63.10875  ? 266 ILE F CB  1 
ATOM   1546 C CG1 . ILE A 1 231 ? 170.47000 315.95200 22.00900  1.000 63.04981  ? 266 ILE F CG1 1 
ATOM   1547 C CG2 . ILE A 1 231 ? 172.83900 316.75700 21.79100  1.000 59.17342  ? 266 ILE F CG2 1 
ATOM   1548 C CD1 . ILE A 1 231 ? 169.88900 317.18100 21.37300  1.000 58.81506  ? 266 ILE F CD1 1 
ATOM   1549 N N   . THR A 1 232 ? 171.02200 315.18100 25.45000  1.000 64.94536  ? 267 THR F N   1 
ATOM   1550 C CA  . THR A 1 232 ? 170.04700 314.81700 26.46900  1.000 66.88303  ? 267 THR F CA  1 
ATOM   1551 C C   . THR A 1 232 ? 168.65300 314.97900 25.88600  1.000 68.55540  ? 267 THR F C   1 
ATOM   1552 O O   . THR A 1 232 ? 168.44600 315.71700 24.92300  1.000 70.03628  ? 267 THR F O   1 
ATOM   1553 C CB  . THR A 1 232 ? 170.16400 315.74000 27.68400  1.000 68.95381  ? 267 THR F CB  1 
ATOM   1554 O OG1 . THR A 1 232 ? 171.39000 315.47400 28.36700  1.000 78.05562  ? 267 THR F OG1 1 
ATOM   1555 C CG2 . THR A 1 232 ? 168.98300 315.53300 28.64300  1.000 67.84712  ? 267 THR F CG2 1 
ATOM   1556 N N   . ASN A 1 233 ? 167.67100 314.32700 26.51000  1.000 68.83267  ? 268 ASN F N   1 
ATOM   1557 C CA  . ASN A 1 233 ? 166.30800 314.48600 26.01900  1.000 68.03780  ? 268 ASN F CA  1 
ATOM   1558 C C   . ASN A 1 233 ? 165.74400 315.89500 26.22100  1.000 67.38424  ? 268 ASN F C   1 
ATOM   1559 O O   . ASN A 1 233 ? 165.06400 316.43100 25.32200  1.000 61.69161  ? 268 ASN F O   1 
ATOM   1560 C CB  . ASN A 1 233 ? 165.43200 313.46000 26.73800  1.000 67.19802  ? 268 ASN F CB  1 
ATOM   1561 C CG  . ASN A 1 233 ? 164.45700 312.77000 25.81900  1.000 70.55283  ? 268 ASN F CG  1 
ATOM   1562 O OD1 . ASN A 1 233 ? 164.85000 312.04200 24.90000  1.000 73.30051  ? 268 ASN F OD1 1 
ATOM   1563 N ND2 . ASN A 1 233 ? 163.16700 313.00900 26.05000  1.000 68.34051  ? 268 ASN F ND2 1 
ATOM   1564 N N   . ASP A 1 234 ? 166.12500 316.56200 27.31800  1.000 67.94736  ? 269 ASP F N   1 
ATOM   1565 C CA  . ASP A 1 234 ? 165.70900 317.94700 27.53100  1.000 66.34176  ? 269 ASP F CA  1 
ATOM   1566 C C   . ASP A 1 234 ? 166.37900 318.91000 26.56000  1.000 67.21877  ? 269 ASP F C   1 
ATOM   1567 O O   . ASP A 1 234 ? 165.76400 319.90100 26.11700  1.000 62.69805  ? 269 ASP F O   1 
ATOM   1568 C CB  . ASP A 1 234 ? 166.00200 318.34600 28.98500  1.000 69.42823  ? 269 ASP F CB  1 
ATOM   1569 C CG  . ASP A 1 234 ? 164.76600 318.23600 29.89900  1.000 79.86222  ? 269 ASP F CG  1 
ATOM   1570 O OD1 . ASP A 1 234 ? 163.62000 318.15500 29.37700  1.000 77.05960  ? 269 ASP F OD1 1 
ATOM   1571 O OD2 . ASP A 1 234 ? 164.94000 318.24000 31.14500  1.000 83.34392  ? 269 ASP F OD2 1 
ATOM   1572 N N   . GLN A 1 235 ? 167.55100 318.53500 26.06400  1.000 65.20477  ? 270 GLN F N   1 
ATOM   1573 C CA  . GLN A 1 235 ? 168.26000 319.41100 25.14700  1.000 59.87777  ? 270 GLN F CA  1 
ATOM   1574 C C   . GLN A 1 235 ? 167.71100 319.23200 23.73700  1.000 53.62292  ? 270 GLN F C   1 
ATOM   1575 O O   . GLN A 1 235 ? 167.73700 320.17200 22.92700  1.000 47.69726  ? 270 GLN F O   1 
ATOM   1576 C CB  . GLN A 1 235 ? 169.74700 319.19500 25.34600  1.000 57.90515  ? 270 GLN F CB  1 
ATOM   1577 C CG  . GLN A 1 235 ? 170.57400 320.22300 24.70900  1.000 60.43710  ? 270 GLN F CG  1 
ATOM   1578 C CD  . GLN A 1 235 ? 171.97400 320.14400 25.21400  1.000 71.45567  ? 270 GLN F CD  1 
ATOM   1579 O OE1 . GLN A 1 235 ? 172.90000 320.73900 24.65100  1.000 66.10300  ? 270 GLN F OE1 1 
ATOM   1580 N NE2 . GLN A 1 235 ? 172.14700 319.40400 26.31500  1.000 78.92218  ? 270 GLN F NE2 1 
ATOM   1581 N N   . LYS A 1 236 ? 167.19700 318.03500 23.43300  1.000 58.29961  ? 271 LYS F N   1 
ATOM   1582 C CA  . LYS A 1 236 ? 166.53400 317.85500 22.15500  1.000 52.77009  ? 271 LYS F CA  1 
ATOM   1583 C C   . LYS A 1 236 ? 165.24900 318.67800 22.16000  1.000 51.70049  ? 271 LYS F C   1 
ATOM   1584 O O   . LYS A 1 236 ? 164.89800 319.30800 21.15400  1.000 51.16870  ? 271 LYS F O   1 
ATOM   1585 C CB  . LYS A 1 236 ? 166.16500 316.38500 21.92200  1.000 52.11431  ? 271 LYS F CB  1 
ATOM   1586 C CG  . LYS A 1 236 ? 167.27400 315.36200 21.79500  1.000 59.50768  ? 271 LYS F CG  1 
ATOM   1587 C CD  . LYS A 1 236 ? 166.64200 313.97500 21.59400  1.000 62.59815  ? 271 LYS F CD  1 
ATOM   1588 C CE  . LYS A 1 236 ? 167.66300 312.84400 21.48100  1.000 65.90619  ? 271 LYS F CE  1 
ATOM   1589 N NZ  . LYS A 1 236 ? 166.98400 311.52600 21.30200  1.000 61.78125  ? 271 LYS F NZ  1 
ATOM   1590 N N   . LYS A 1 237 ? 164.56200 318.73100 23.31000  1.000 53.81734  ? 272 LYS F N   1 
ATOM   1591 C CA  . LYS A 1 237 ? 163.36800 319.57500 23.39400  1.000 52.30980  ? 272 LYS F CA  1 
ATOM   1592 C C   . LYS A 1 237 ? 163.71500 321.04400 23.22600  1.000 49.30673  ? 272 LYS F C   1 
ATOM   1593 O O   . LYS A 1 237 ? 162.98500 321.79900 22.55400  1.000 46.12986  ? 272 LYS F O   1 
ATOM   1594 C CB  . LYS A 1 237 ? 162.68700 319.36200 24.74900  1.000 60.44608  ? 272 LYS F CB  1 
ATOM   1595 C CG  . LYS A 1 237 ? 161.31800 320.01900 24.92300  1.000 63.06699  ? 272 LYS F CG  1 
ATOM   1596 C CD  . LYS A 1 237 ? 160.30000 319.62200 23.84600  1.000 58.84199  ? 272 LYS F CD  1 
ATOM   1597 C CE  . LYS A 1 237 ? 158.93600 320.28900 24.11600  1.000 58.37397  ? 272 LYS F CE  1 
ATOM   1598 N NZ  . LYS A 1 237 ? 157.92500 320.06300 23.03700  1.000 61.81601  ? 272 LYS F NZ  1 
ATOM   1599 N N   . LEU A 1 238 ? 164.90800 321.42300 23.66100  1.000 50.19510  ? 273 LEU F N   1 
ATOM   1600 C CA  . LEU A 1 238 ? 165.27500 322.82200 23.53700  1.000 46.22638  ? 273 LEU F CA  1 
ATOM   1601 C C   . LEU A 1 238 ? 165.50000 323.16600 22.07600  1.000 43.98665  ? 273 LEU F C   1 
ATOM   1602 O O   . LEU A 1 238 ? 164.92500 324.13000 21.55700  1.000 42.53888  ? 273 LEU F O   1 
ATOM   1603 C CB  . LEU A 1 238 ? 166.55600 323.10500 24.31700  1.000 47.25555  ? 273 LEU F CB  1 
ATOM   1604 C CG  . LEU A 1 238 ? 166.96900 324.59200 24.36800  1.000 46.29623  ? 273 LEU F CG  1 
ATOM   1605 C CD1 . LEU A 1 238 ? 165.94200 325.48100 25.09100  1.000 44.99241  ? 273 LEU F CD1 1 
ATOM   1606 C CD2 . LEU A 1 238 ? 168.38600 324.82300 24.87400  1.000 43.07000  ? 273 LEU F CD2 1 
ATOM   1607 N N   . MET A 1 239 ? 166.27200 322.34200 21.37400  1.000 39.85392  ? 274 MET F N   1 
ATOM   1608 C CA  . MET A 1 239 ? 166.51700 322.68200 19.98600  1.000 40.02707  ? 274 MET F CA  1 
ATOM   1609 C C   . MET A 1 239 ? 165.27100 322.55000 19.11900  1.000 39.60526  ? 274 MET F C   1 
ATOM   1610 O O   . MET A 1 239 ? 165.10000 323.31000 18.16100  1.000 35.73450  ? 274 MET F O   1 
ATOM   1611 C CB  . MET A 1 239 ? 167.64300 321.83500 19.43000  1.000 37.80475  ? 274 MET F CB  1 
ATOM   1612 C CG  . MET A 1 239 ? 168.90300 322.01200 20.19400  1.000 32.53700  ? 274 MET F CG  1 
ATOM   1613 S SD  . MET A 1 239 ? 170.16300 320.99100 19.48100  1.000 36.07866  ? 274 MET F SD  1 
ATOM   1614 C CE  . MET A 1 239 ? 171.58800 321.53300 20.46400  1.000 45.47775  ? 274 MET F CE  1 
ATOM   1615 N N   . SER A 1 240 ? 164.36100 321.64900 19.46500  1.000 43.53179  ? 275 SER F N   1 
ATOM   1616 C CA  . SER A 1 240 ? 163.17600 321.48700 18.63900  1.000 40.36422  ? 275 SER F CA  1 
ATOM   1617 C C   . SER A 1 240 ? 162.18700 322.62500 18.82000  1.000 45.25311  ? 275 SER F C   1 
ATOM   1618 O O   . SER A 1 240 ? 161.46300 322.95600 17.87400  1.000 52.35639  ? 275 SER F O   1 
ATOM   1619 C CB  . SER A 1 240 ? 162.54200 320.13900 18.91400  1.000 41.45052  ? 275 SER F CB  1 
ATOM   1620 O OG  . SER A 1 240 ? 163.49400 319.13700 18.59600  1.000 43.15937  ? 275 SER F OG  1 
ATOM   1621 N N   . ASN A 1 241 ? 162.17200 323.27900 19.98300  1.000 45.02264  ? 276 ASN F N   1 
ATOM   1622 C CA  . ASN A 1 241 ? 161.26800 324.42100 20.13900  1.000 47.75718  ? 276 ASN F CA  1 
ATOM   1623 C C   . ASN A 1 241 ? 161.84100 325.73800 19.63500  1.000 47.46464  ? 276 ASN F C   1 
ATOM   1624 O O   . ASN A 1 241 ? 161.11900 326.74400 19.62200  1.000 52.86125  ? 276 ASN F O   1 
ATOM   1625 C CB  . ASN A 1 241 ? 160.78800 324.56100 21.57200  1.000 50.71180  ? 276 ASN F CB  1 
ATOM   1626 C CG  . ASN A 1 241 ? 159.90500 323.42300 21.97700  1.000 51.28500  ? 276 ASN F CG  1 
ATOM   1627 O OD1 . ASN A 1 241 ? 159.96400 322.94200 23.10800  1.000 51.40849  ? 276 ASN F OD1 1 
ATOM   1628 N ND2 . ASN A 1 241 ? 159.04400 322.99600 21.05200  1.000 50.17639  ? 276 ASN F ND2 1 
ATOM   1629 N N   . ASN A 1 242 ? 163.11600 325.77800 19.26600  1.000 43.31550  ? 277 ASN F N   1 
ATOM   1630 C CA  . ASN A 1 242 ? 163.72600 326.98800 18.74100  1.000 42.06412  ? 277 ASN F CA  1 
ATOM   1631 C C   . ASN A 1 242 ? 164.46800 326.65900 17.46400  1.000 41.61622  ? 277 ASN F C   1 
ATOM   1632 O O   . ASN A 1 242 ? 165.63300 327.01800 17.28000  1.000 40.99247  ? 277 ASN F O   1 
ATOM   1633 C CB  . ASN A 1 242 ? 164.66100 327.62800 19.75900  1.000 36.93991  ? 277 ASN F CB  1 
ATOM   1634 C CG  . ASN A 1 242 ? 163.97500 327.92900 21.05800  1.000 36.26303  ? 277 ASN F CG  1 
ATOM   1635 O OD1 . ASN A 1 242 ? 163.37000 328.98500 21.21400  1.000 39.46135  ? 277 ASN F OD1 1 
ATOM   1636 N ND2 . ASN A 1 242 ? 164.04100 326.99600 21.99500  1.000 35.75819  ? 277 ASN F ND2 1 
ATOM   1637 N N   . VAL A 1 243 ? 163.76000 326.04100 16.51100  1.000 42.01675  ? 278 VAL F N   1 
ATOM   1638 C CA  . VAL A 1 243 ? 164.43100 325.61800 15.28300  1.000 39.47491  ? 278 VAL F CA  1 
ATOM   1639 C C   . VAL A 1 243 ? 164.89800 326.81900 14.47500  1.000 40.23094  ? 278 VAL F C   1 
ATOM   1640 O O   . VAL A 1 243 ? 165.91500 326.74200 13.77900  1.000 39.63002  ? 278 VAL F O   1 
ATOM   1641 C CB  . VAL A 1 243 ? 163.50800 324.73800 14.43100  1.000 39.13830  ? 278 VAL F CB  1 
ATOM   1642 C CG1 . VAL A 1 243 ? 163.20400 323.46200 15.14700  1.000 42.68671  ? 278 VAL F CG1 1 
ATOM   1643 C CG2 . VAL A 1 243 ? 162.24200 325.47700 14.09800  1.000 44.98178  ? 278 VAL F CG2 1 
ATOM   1644 N N   . GLN A 1 244 ? 164.18100 327.94000 14.52900  1.000 42.36628  ? 279 GLN F N   1 
ATOM   1645 C CA  . GLN A 1 244 ? 164.64500 329.08300 13.75700  1.000 42.16570  ? 279 GLN F CA  1 
ATOM   1646 C C   . GLN A 1 244 ? 165.95600 329.64000 14.34300  1.000 40.30085  ? 279 GLN F C   1 
ATOM   1647 O O   . GLN A 1 244 ? 166.87700 330.02800 13.60000  1.000 37.85102  ? 279 GLN F O   1 
ATOM   1648 C CB  . GLN A 1 244 ? 163.55200 330.16300 13.66000  1.000 44.20861  ? 279 GLN F CB  1 
ATOM   1649 C CG  . GLN A 1 244 ? 162.90000 330.68500 14.97400  1.000 55.50713  ? 279 GLN F CG  1 
ATOM   1650 C CD  . GLN A 1 244 ? 162.18200 329.61400 15.79300  1.000 58.00227  ? 279 GLN F CD  1 
ATOM   1651 O OE1 . GLN A 1 244 ? 161.56500 328.70400 15.23200  1.000 57.99550  ? 279 GLN F OE1 1 
ATOM   1652 N NE2 . GLN A 1 244 ? 162.23100 329.74300 17.14200  1.000 54.01595  ? 279 GLN F NE2 1 
ATOM   1653 N N   . ILE A 1 245 ? 166.09000 329.66000 15.67200  1.000 38.59829  ? 280 ILE F N   1 
ATOM   1654 C CA  . ILE A 1 245 ? 167.36900 330.07000 16.23400  1.000 35.76370  ? 280 ILE F CA  1 
ATOM   1655 C C   . ILE A 1 245 ? 168.45600 329.04000 15.92400  1.000 33.34795  ? 280 ILE F C   1 
ATOM   1656 O O   . ILE A 1 245 ? 169.60900 329.39800 15.67600  1.000 34.65021  ? 280 ILE F O   1 
ATOM   1657 C CB  . ILE A 1 245 ? 167.26100 330.34000 17.74200  1.000 35.68391  ? 280 ILE F CB  1 
ATOM   1658 C CG1 . ILE A 1 245 ? 166.37900 331.54600 18.01700  1.000 37.57999  ? 280 ILE F CG1 1 
ATOM   1659 C CG2 . ILE A 1 245 ? 168.61200 330.65900 18.27400  1.000 36.06320  ? 280 ILE F CG2 1 
ATOM   1660 C CD1 . ILE A 1 245 ? 166.32300 331.87400 19.45500  1.000 35.99918  ? 280 ILE F CD1 1 
ATOM   1661 N N   . VAL A 1 246 ? 168.12100 327.74900 15.92200  1.000 31.48261  ? 281 VAL F N   1 
ATOM   1662 C CA  . VAL A 1 246 ? 169.13200 326.75900 15.56300  1.000 28.52390  ? 281 VAL F CA  1 
ATOM   1663 C C   . VAL A 1 246 ? 169.61100 326.97600 14.13200  1.000 29.88345  ? 281 VAL F C   1 
ATOM   1664 O O   . VAL A 1 246 ? 170.81700 326.92300 13.85400  1.000 29.54854  ? 281 VAL F O   1 
ATOM   1665 C CB  . VAL A 1 246 ? 168.58700 325.33200 15.76700  1.000 29.64636  ? 281 VAL F CB  1 
ATOM   1666 C CG1 . VAL A 1 246 ? 169.51600 324.33100 15.17500  1.000 27.44307  ? 281 VAL F CG1 1 
ATOM   1667 C CG2 . VAL A 1 246 ? 168.39700 325.03200 17.23200  1.000 33.77908  ? 281 VAL F CG2 1 
ATOM   1668 N N   . ARG A 1 247 ? 168.69100 327.26200 13.20300  1.000 34.01218  ? 282 ARG F N   1 
ATOM   1669 C CA  . ARG A 1 247 ? 169.12500 327.52800 11.83300  1.000 31.95316  ? 282 ARG F CA  1 
ATOM   1670 C C   . ARG A 1 247 ? 170.03200 328.74900 11.77700  1.000 33.48226  ? 282 ARG F C   1 
ATOM   1671 O O   . ARG A 1 247 ? 171.08200 328.70900 11.12100  1.000 33.43786  ? 282 ARG F O   1 
ATOM   1672 C CB  . ARG A 1 247 ? 167.94300 327.73600 10.87600  1.000 32.70554  ? 282 ARG F CB  1 
ATOM   1673 C CG  . ARG A 1 247 ? 167.07900 326.53000 10.62100  1.000 38.85223  ? 282 ARG F CG  1 
ATOM   1674 C CD  . ARG A 1 247 ? 165.96400 326.79300 9.61200   1.000 39.10707  ? 282 ARG F CD  1 
ATOM   1675 N NE  . ARG A 1 247 ? 165.21400 325.56600 9.36600   1.000 39.91053  ? 282 ARG F NE  1 
ATOM   1676 C CZ  . ARG A 1 247 ? 165.56400 324.64700 8.47400   1.000 43.21893  ? 282 ARG F CZ  1 
ATOM   1677 N NH1 . ARG A 1 247 ? 166.64900 324.78800 7.72400   1.000 40.42520  ? 282 ARG F NH1 1 
ATOM   1678 N NH2 . ARG A 1 247 ? 164.82400 323.54600 8.34700   1.000 46.22634  ? 282 ARG F NH2 1 
ATOM   1679 N N   . GLN A 1 248 ? 169.68700 329.82200 12.51800  1.000 30.92441  ? 283 GLN F N   1 
ATOM   1680 C CA  . GLN A 1 248 ? 170.52000 331.01700 12.45200  1.000 33.03665  ? 283 GLN F CA  1 
ATOM   1681 C C   . GLN A 1 248 ? 171.90200 330.80700 13.04700  1.000 34.23382  ? 283 GLN F C   1 
ATOM   1682 O O   . GLN A 1 248 ? 172.83800 331.53400 12.69700  1.000 33.42333  ? 283 GLN F O   1 
ATOM   1683 C CB  . GLN A 1 248 ? 169.83800 332.23200 13.08200  1.000 30.94635  ? 283 GLN F CB  1 
ATOM   1684 C CG  . GLN A 1 248 ? 168.61600 332.68300 12.30700  1.000 40.64486  ? 283 GLN F CG  1 
ATOM   1685 C CD  . GLN A 1 248 ? 167.81600 333.78500 12.97400  1.000 51.46480  ? 283 GLN F CD  1 
ATOM   1686 O OE1 . GLN A 1 248 ? 168.05700 334.14900 14.12100  1.000 53.60030  ? 283 GLN F OE1 1 
ATOM   1687 N NE2 . GLN A 1 248 ? 166.88400 334.36300 12.22500  1.000 56.80451  ? 283 GLN F NE2 1 
ATOM   1688 N N   . GLN A 1 249 ? 172.08400 329.77900 13.84700  1.000 32.50850  ? 284 GLN F N   1 
ATOM   1689 C CA  . GLN A 1 249 ? 173.38100 329.48800 14.42000  1.000 26.85499  ? 284 GLN F CA  1 
ATOM   1690 C C   . GLN A 1 249 ? 174.00600 328.23300 13.83100  1.000 30.37470  ? 284 GLN F C   1 
ATOM   1691 O O   . GLN A 1 249 ? 174.88700 327.63000 14.44600  1.000 35.72216  ? 284 GLN F O   1 
ATOM   1692 C CB  . GLN A 1 249 ? 173.17900 329.37900 15.93200  1.000 28.66761  ? 284 GLN F CB  1 
ATOM   1693 C CG  . GLN A 1 249 ? 172.79900 330.73900 16.52700  1.000 29.70280  ? 284 GLN F CG  1 
ATOM   1694 C CD  . GLN A 1 249 ? 172.68600 330.76900 18.04500  1.000 32.70382  ? 284 GLN F CD  1 
ATOM   1695 O OE1 . GLN A 1 249 ? 172.60600 329.73100 18.71700  1.000 29.18776  ? 284 GLN F OE1 1 
ATOM   1696 N NE2 . GLN A 1 249 ? 172.77400 331.97700 18.60000  1.000 36.97622  ? 284 GLN F NE2 1 
ATOM   1697 N N   . SER A 1 250 ? 173.67100 327.90500 12.58500  1.000 32.21555  ? 285 SER F N   1 
ATOM   1698 C CA  . SER A 1 250 ? 174.22700 326.72700 11.93700  1.000 32.06297  ? 285 SER F CA  1 
ATOM   1699 C C   . SER A 1 250 ? 174.91700 327.11200 10.65100  1.000 31.04589  ? 285 SER F C   1 
ATOM   1700 O O   . SER A 1 250 ? 174.71400 328.19900 10.11400  1.000 29.57520  ? 285 SER F O   1 
ATOM   1701 C CB  . SER A 1 250 ? 173.14900 325.70500 11.63200  1.000 31.22066  ? 285 SER F CB  1 
ATOM   1702 O OG  . SER A 1 250 ? 172.56400 325.30500 12.85400  1.000 31.77649  ? 285 SER F OG  1 
ATOM   1703 N N   . TYR A 1 251 ? 175.71800 326.18800 10.14800  1.000 35.42303  ? 286 TYR F N   1 
ATOM   1704 C CA  . TYR A 1 251 ? 176.42000 326.38300 8.88800   1.000 38.67906  ? 286 TYR F CA  1 
ATOM   1705 C C   . TYR A 1 251 ? 176.21400 325.19300 7.96600   1.000 39.86099  ? 286 TYR F C   1 
ATOM   1706 O O   . TYR A 1 251 ? 176.12700 324.04500 8.40700   1.000 40.10956  ? 286 TYR F O   1 
ATOM   1707 C CB  . TYR A 1 251 ? 177.92900 326.56200 9.06500   1.000 34.10213  ? 286 TYR F CB  1 
ATOM   1708 C CG  . TYR A 1 251 ? 178.42200 327.88500 9.59300   1.000 36.55739  ? 286 TYR F CG  1 
ATOM   1709 C CD1 . TYR A 1 251 ? 178.65000 328.96200 8.74900   1.000 37.71017  ? 286 TYR F CD1 1 
ATOM   1710 C CD2 . TYR A 1 251 ? 178.70600 328.04600 10.94200  1.000 38.09127  ? 286 TYR F CD2 1 
ATOM   1711 C CE1 . TYR A 1 251 ? 179.13600 330.15400 9.24300   1.000 37.28427  ? 286 TYR F CE1 1 
ATOM   1712 C CE2 . TYR A 1 251 ? 179.18200 329.22900 11.43600  1.000 37.91102  ? 286 TYR F CE2 1 
ATOM   1713 C CZ  . TYR A 1 251 ? 179.40300 330.27600 10.59200  1.000 38.38505  ? 286 TYR F CZ  1 
ATOM   1714 O OH  . TYR A 1 251 ? 179.88600 331.44500 11.13000  1.000 33.51632  ? 286 TYR F OH  1 
ATOM   1715 N N   . SER A 1 252 ? 176.15700 325.48800 6.67500   1.000 38.72320  ? 287 SER F N   1 
ATOM   1716 C CA  . SER A 1 252 ? 176.12500 324.47400 5.63600   1.000 37.05360  ? 287 SER F CA  1 
ATOM   1717 C C   . SER A 1 252 ? 177.34600 324.65400 4.74000   1.000 39.26527  ? 287 SER F C   1 
ATOM   1718 O O   . SER A 1 252 ? 177.51100 325.70800 4.11100   1.000 41.15620  ? 287 SER F O   1 
ATOM   1719 C CB  . SER A 1 252 ? 174.82300 324.54900 4.84700   1.000 34.35968  ? 287 SER F CB  1 
ATOM   1720 O OG  . SER A 1 252 ? 174.77600 323.51400 3.90400   1.000 39.79091  ? 287 SER F OG  1 
ATOM   1721 N N   . ILE A 1 253 ? 178.21000 323.63800 4.70700   1.000 37.85550  ? 288 ILE F N   1 
ATOM   1722 C CA  . ILE A 1 253 ? 179.48900 323.67200 3.99900   1.000 39.96113  ? 288 ILE F CA  1 
ATOM   1723 C C   . ILE A 1 253 ? 179.48200 322.64300 2.87700   1.000 45.56530  ? 288 ILE F C   1 
ATOM   1724 O O   . ILE A 1 253 ? 179.19600 321.45800 3.10200   1.000 46.66302  ? 288 ILE F O   1 
ATOM   1725 C CB  . ILE A 1 253 ? 180.68400 323.40000 4.93000   1.000 39.29588  ? 288 ILE F CB  1 
ATOM   1726 C CG1 . ILE A 1 253 ? 180.59400 324.23200 6.19800   1.000 41.83197  ? 288 ILE F CG1 1 
ATOM   1727 C CG2 . ILE A 1 253 ? 181.97800 323.58400 4.19800   1.000 44.05506  ? 288 ILE F CG2 1 
ATOM   1728 C CD1 . ILE A 1 253 ? 180.30100 323.39400 7.41800   1.000 43.84555  ? 288 ILE F CD1 1 
ATOM   1729 N N   . MET A 1 254 ? 179.84000 323.08000 1.68400   1.000 45.14270  ? 289 MET F N   1 
ATOM   1730 C CA  . MET A 1 254 ? 179.89300 322.15700 0.56600   1.000 44.21844  ? 289 MET F CA  1 
ATOM   1731 C C   . MET A 1 254 ? 181.22200 321.39800 0.58800   1.000 45.37370  ? 289 MET F C   1 
ATOM   1732 O O   . MET A 1 254 ? 182.29900 321.99300 0.67500   1.000 48.57322  ? 289 MET F O   1 
ATOM   1733 C CB  . MET A 1 254 ? 179.74800 322.94300 -0.74500  1.000 42.81115  ? 289 MET F CB  1 
ATOM   1734 C CG  . MET A 1 254 ? 178.66200 322.49100 -1.71400  1.000 44.06822  ? 289 MET F CG  1 
ATOM   1735 S SD  . MET A 1 254 ? 178.92100 320.88600 -2.52200  1.000 67.29594  ? 289 MET F SD  1 
ATOM   1736 C CE  . MET A 1 254 ? 180.52000 321.01800 -3.38600  1.000 58.95266  ? 289 MET F CE  1 
ATOM   1737 N N   . CYS A 1 255 ? 181.12700 320.07800 0.50200   1.000 49.06560  ? 290 CYS F N   1 
ATOM   1738 C CA  . CYS A 1 255 ? 182.21700 319.10300 0.49400   1.000 50.26793  ? 290 CYS F CA  1 
ATOM   1739 C C   . CYS A 1 255 ? 182.55600 318.76000 -0.94000  1.000 50.26234  ? 290 CYS F C   1 
ATOM   1740 O O   . CYS A 1 255 ? 183.40200 319.40600 -1.56100  1.000 51.61972  ? 290 CYS F O   1 
ATOM   1741 C CB  . CYS A 1 255 ? 181.95200 317.83500 1.31100   1.000 51.96692  ? 290 CYS F CB  1 
ATOM   1742 S SG  . CYS A 1 255 ? 182.10200 317.99000 3.13500   1.000 78.83848  ? 290 CYS F SG  1 
ATOM   1743 N N   . ILE A 1 256 ? 182.05300 317.62800 -1.40700  1.000 51.70718  ? 291 ILE F N   1 
ATOM   1744 C CA  . ILE A 1 256 ? 182.49100 317.15500 -2.70500  1.000 52.61130  ? 291 ILE F CA  1 
ATOM   1745 C C   . ILE A 1 256 ? 181.37100 316.56600 -3.54700  1.000 51.85310  ? 291 ILE F C   1 
ATOM   1746 O O   . ILE A 1 256 ? 180.37000 316.06700 -3.02500  1.000 52.15392  ? 291 ILE F O   1 
ATOM   1747 C CB  . ILE A 1 256 ? 183.51400 316.05300 -2.36000  1.000 58.73343  ? 291 ILE F CB  1 
ATOM   1748 C CG1 . ILE A 1 256 ? 184.37300 315.61000 -3.54500  1.000 66.83414  ? 291 ILE F CG1 1 
ATOM   1749 C CG2 . ILE A 1 256 ? 182.77800 314.88600 -1.63300  1.000 49.44404  ? 291 ILE F CG2 1 
ATOM   1750 C CD1 . ILE A 1 256 ? 185.17600 314.31600 -3.23600  1.000 64.56485  ? 291 ILE F CD1 1 
ATOM   1751 N N   . ILE A 1 257 ? 181.52800 316.65600 -4.87300  1.000 52.81819  ? 292 ILE F N   1 
ATOM   1752 C CA  . ILE A 1 257 ? 180.67700 315.92900 -5.80900  1.000 51.05906  ? 292 ILE F CA  1 
ATOM   1753 C C   . ILE A 1 257 ? 181.60000 314.90900 -6.49000  1.000 53.56761  ? 292 ILE F C   1 
ATOM   1754 O O   . ILE A 1 257 ? 182.47100 315.28700 -7.28800  1.000 52.81061  ? 292 ILE F O   1 
ATOM   1755 C CB  . ILE A 1 257 ? 180.00600 316.90800 -6.78100  1.000 52.07589  ? 292 ILE F CB  1 
ATOM   1756 C CG1 . ILE A 1 257 ? 179.08700 316.21500 -7.76400  1.000 47.25947  ? 292 ILE F CG1 1 
ATOM   1757 C CG2 . ILE A 1 257 ? 181.05200 317.75700 -7.52700  1.000 49.31393  ? 292 ILE F CG2 1 
ATOM   1758 C CD1 . ILE A 1 257 ? 178.56500 317.18100 -8.80100  1.000 46.31854  ? 292 ILE F CD1 1 
ATOM   1759 N N   . LYS A 1 258 ? 181.40200 313.61600 -6.22900  1.000 55.41681  ? 293 LYS F N   1 
ATOM   1760 C CA  . LYS A 1 258 ? 182.33000 312.61100 -6.75100  1.000 56.85359  ? 293 LYS F CA  1 
ATOM   1761 C C   . LYS A 1 258 ? 181.65400 311.24600 -6.77100  1.000 63.58083  ? 293 LYS F C   1 
ATOM   1762 O O   . LYS A 1 258 ? 181.04500 310.86800 -5.75900  1.000 62.94034  ? 293 LYS F O   1 
ATOM   1763 C CB  . LYS A 1 258 ? 183.63700 312.52000 -5.93700  1.000 57.13213  ? 293 LYS F CB  1 
ATOM   1764 C CG  . LYS A 1 258 ? 184.56700 311.43900 -6.50200  1.000 63.62468  ? 293 LYS F CG  1 
ATOM   1765 C CD  . LYS A 1 258 ? 185.92600 311.24000 -5.79900  1.000 67.39390  ? 293 LYS F CD  1 
ATOM   1766 C CE  . LYS A 1 258 ? 185.76600 310.68200 -4.37700  1.000 69.36985  ? 293 LYS F CE  1 
ATOM   1767 N NZ  . LYS A 1 258 ? 187.04600 310.50300 -3.63200  1.000 65.93418  ? 293 LYS F NZ  1 
ATOM   1768 N N   . GLU A 1 259 ? 181.73300 310.51200 -7.88500  1.000 60.29623  ? 294 GLU F N   1 
ATOM   1769 C CA  . GLU A 1 259 ? 181.21100 309.13900 -7.91000  1.000 59.83878  ? 294 GLU F CA  1 
ATOM   1770 C C   . GLU A 1 259 ? 179.73100 309.09600 -7.51900  1.000 62.29552  ? 294 GLU F C   1 
ATOM   1771 O O   . GLU A 1 259 ? 179.31100 308.38000 -6.58800  1.000 52.58984  ? 294 GLU F O   1 
ATOM   1772 C CB  . GLU A 1 259 ? 182.01400 308.27600 -6.92100  1.000 61.31040  ? 294 GLU F CB  1 
ATOM   1773 C CG  . GLU A 1 259 ? 183.50300 308.08500 -7.21200  1.000 63.87871  ? 294 GLU F CG  1 
ATOM   1774 C CD  . GLU A 1 259 ? 184.23800 307.27000 -6.12300  1.000 67.42491  ? 294 GLU F CD  1 
ATOM   1775 O OE1 . GLU A 1 259 ? 183.61800 306.86300 -5.10700  1.000 68.60911  ? 294 GLU F OE1 1 
ATOM   1776 O OE2 . GLU A 1 259 ? 185.45800 307.06100 -6.28000  1.000 71.75366  ? 294 GLU F OE2 1 
ATOM   1777 N N   . GLU A 1 260 ? 178.94100 309.87400 -8.26500  1.000 62.49785  ? 295 GLU F N   1 
ATOM   1778 C CA  . GLU A 1 260 ? 177.47900 309.89400 -8.16100  1.000 62.10797  ? 295 GLU F CA  1 
ATOM   1779 C C   . GLU A 1 260 ? 177.01500 310.30500 -6.75900  1.000 56.54103  ? 295 GLU F C   1 
ATOM   1780 O O   . GLU A 1 260 ? 175.95400 309.86300 -6.28200  1.000 56.42575  ? 295 GLU F O   1 
ATOM   1781 C CB  . GLU A 1 260 ? 176.87500 308.52200 -8.49900  1.000 65.71528  ? 295 GLU F CB  1 
ATOM   1782 C CG  . GLU A 1 260 ? 177.44600 307.75600 -9.68800  1.000 66.32647  ? 295 GLU F CG  1 
ATOM   1783 C CD  . GLU A 1 260 ? 176.71100 306.42800 -9.88900  1.000 68.81431  ? 295 GLU F CD  1 
ATOM   1784 O OE1 . GLU A 1 260 ? 177.03800 305.44800 -9.17300  1.000 62.27865  ? 295 GLU F OE1 1 
ATOM   1785 O OE2 . GLU A 1 260 ? 175.80000 306.36700 -10.74600 1.000 72.92960  ? 295 GLU F OE2 1 
ATOM   1786 N N   . VAL A 1 261 ? 177.77600 311.15600 -6.07700  1.000 51.83721  ? 296 VAL F N   1 
ATOM   1787 C CA  . VAL A 1 261 ? 177.39200 311.58600 -4.73900  1.000 56.52817  ? 296 VAL F CA  1 
ATOM   1788 C C   . VAL A 1 261 ? 177.68200 313.06800 -4.57500  1.000 53.33045  ? 296 VAL F C   1 
ATOM   1789 O O   . VAL A 1 261 ? 178.77700 313.53500 -4.90700  1.000 51.54350  ? 296 VAL F O   1 
ATOM   1790 C CB  . VAL A 1 261 ? 178.05700 310.77800 -3.60900  1.000 58.27702  ? 296 VAL F CB  1 
ATOM   1791 C CG1 . VAL A 1 261 ? 177.75200 311.45100 -2.27800  1.000 51.16982  ? 296 VAL F CG1 1 
ATOM   1792 C CG2 . VAL A 1 261 ? 177.52400 309.35200 -3.58400  1.000 62.66268  ? 296 VAL F CG2 1 
ATOM   1793 N N   . LEU A 1 262 ? 176.68900 313.81600 -4.12900  1.000 48.74951  ? 297 LEU F N   1 
ATOM   1794 C CA  . LEU A 1 262 ? 176.89100 315.20000 -3.74800  1.000 49.50939  ? 297 LEU F CA  1 
ATOM   1795 C C   . LEU A 1 262 ? 176.79900 315.23000 -2.23200  1.000 49.71939  ? 297 LEU F C   1 
ATOM   1796 O O   . LEU A 1 262 ? 175.79400 314.77900 -1.66900  1.000 47.66913  ? 297 LEU F O   1 
ATOM   1797 C CB  . LEU A 1 262 ? 175.86100 316.14600 -4.35900  1.000 49.91341  ? 297 LEU F CB  1 
ATOM   1798 C CG  . LEU A 1 262 ? 175.83300 317.46900 -3.57600  1.000 43.30357  ? 297 LEU F CG  1 
ATOM   1799 C CD1 . LEU A 1 262 ? 177.16100 318.16500 -3.67300  1.000 45.80517  ? 297 LEU F CD1 1 
ATOM   1800 C CD2 . LEU A 1 262 ? 174.77200 318.37800 -4.09400  1.000 40.82125  ? 297 LEU F CD2 1 
ATOM   1801 N N   . ALA A 1 263 ? 177.88700 315.60900 -1.57000  1.000 50.03825  ? 298 ALA F N   1 
ATOM   1802 C CA  . ALA A 1 263 ? 177.92300 315.60300 -0.11400  1.000 47.73923  ? 298 ALA F CA  1 
ATOM   1803 C C   . ALA A 1 263 ? 178.28400 317.00100 0.38900   1.000 40.14834  ? 298 ALA F C   1 
ATOM   1804 O O   . ALA A 1 263 ? 179.18400 317.67200 -0.14900  1.000 39.46490  ? 298 ALA F O   1 
ATOM   1805 C CB  . ALA A 1 263 ? 178.91400 314.56000 0.42000   1.000 44.48795  ? 298 ALA F CB  1 
ATOM   1806 N N   . TYR A 1 264 ? 177.62500 317.38600 1.47300   1.000 37.09486  ? 299 TYR F N   1 
ATOM   1807 C CA  . TYR A 1 264 ? 177.91000 318.63400 2.16700   1.000 42.13141  ? 299 TYR F CA  1 
ATOM   1808 C C   . TYR A 1 264 ? 177.59200 318.44200 3.63900   1.000 41.63262  ? 299 TYR F C   1 
ATOM   1809 O O   . TYR A 1 264 ? 176.74400 317.62000 3.99700   1.000 39.39798  ? 299 TYR F O   1 
ATOM   1810 C CB  . TYR A 1 264 ? 177.13400 319.84100 1.60500   1.000 39.61845  ? 299 TYR F CB  1 
ATOM   1811 C CG  . TYR A 1 264 ? 175.61500 319.74100 1.64200   1.000 36.58436  ? 299 TYR F CG  1 
ATOM   1812 C CD1 . TYR A 1 264 ? 174.91600 319.18400 0.59000   1.000 34.04523  ? 299 TYR F CD1 1 
ATOM   1813 C CD2 . TYR A 1 264 ? 174.89100 320.13700 2.75600   1.000 37.37300  ? 299 TYR F CD2 1 
ATOM   1814 C CE1 . TYR A 1 264 ? 173.54700 319.07300 0.61100   1.000 30.71983  ? 299 TYR F CE1 1 
ATOM   1815 C CE2 . TYR A 1 264 ? 173.51300 320.01600 2.78700   1.000 36.70674  ? 299 TYR F CE2 1 
ATOM   1816 C CZ  . TYR A 1 264 ? 172.84800 319.47700 1.70600   1.000 33.80516  ? 299 TYR F CZ  1 
ATOM   1817 O OH  . TYR A 1 264 ? 171.47300 319.34900 1.70600   1.000 36.58814  ? 299 TYR F OH  1 
ATOM   1818 N N   . VAL A 1 265 ? 178.33400 319.14400 4.49700   1.000 40.38246  ? 300 VAL F N   1 
ATOM   1819 C CA  . VAL A 1 265 ? 178.22800 318.95000 5.93800   1.000 41.23730  ? 300 VAL F CA  1 
ATOM   1820 C C   . VAL A 1 265 ? 177.36200 320.05300 6.51900   1.000 39.48232  ? 300 VAL F C   1 
ATOM   1821 O O   . VAL A 1 265 ? 177.43700 321.21100 6.09100   1.000 36.95919  ? 300 VAL F O   1 
ATOM   1822 C CB  . VAL A 1 265 ? 179.60700 318.91300 6.62600   1.000 45.34611  ? 300 VAL F CB  1 
ATOM   1823 C CG1 . VAL A 1 265 ? 180.49100 317.82800 6.04200   1.000 45.16114  ? 300 VAL F CG1 1 
ATOM   1824 C CG2 . VAL A 1 265 ? 180.27800 320.23600 6.50600   1.000 51.67539  ? 300 VAL F CG2 1 
ATOM   1825 N N   . VAL A 1 266 ? 176.42200 319.66100 7.35900   1.000 43.98916  ? 301 VAL F N   1 
ATOM   1826 C CA  . VAL A 1 266 ? 175.65200 320.59400 8.16000   1.000 41.97712  ? 301 VAL F CA  1 
ATOM   1827 C C   . VAL A 1 266 ? 176.17600 320.53900 9.58700   1.000 40.93219  ? 301 VAL F C   1 
ATOM   1828 O O   . VAL A 1 266 ? 176.31600 319.45500 10.17100  1.000 39.94332  ? 301 VAL F O   1 
ATOM   1829 C CB  . VAL A 1 266 ? 174.15400 320.30500 8.08600   1.000 38.94778  ? 301 VAL F CB  1 
ATOM   1830 C CG1 . VAL A 1 266 ? 173.43300 321.19200 9.05300   1.000 35.03806  ? 301 VAL F CG1 1 
ATOM   1831 C CG2 . VAL A 1 266 ? 173.71000 320.64000 6.70100   1.000 37.78061  ? 301 VAL F CG2 1 
ATOM   1832 N N   . GLN A 1 267 ? 176.58400 321.70300 10.07800  1.000 42.46251  ? 302 GLN F N   1 
ATOM   1833 C CA  . GLN A 1 267 ? 177.20100 321.90600 11.38500  1.000 37.09794  ? 302 GLN F CA  1 
ATOM   1834 C C   . GLN A 1 267 ? 176.18100 322.56000 12.32000  1.000 31.89009  ? 302 GLN F C   1 
ATOM   1835 O O   . GLN A 1 267 ? 175.83400 323.73300 12.13500  1.000 32.42131  ? 302 GLN F O   1 
ATOM   1836 C CB  . GLN A 1 267 ? 178.45600 322.74300 11.18300  1.000 36.31242  ? 302 GLN F CB  1 
ATOM   1837 C CG  . GLN A 1 267 ? 179.41200 322.80200 12.29900  1.000 38.24794  ? 302 GLN F CG  1 
ATOM   1838 C CD  . GLN A 1 267 ? 180.67200 323.53700 11.87800  1.000 39.40801  ? 302 GLN F CD  1 
ATOM   1839 O OE1 . GLN A 1 267 ? 181.56100 322.97600 11.22200  1.000 40.46813  ? 302 GLN F OE1 1 
ATOM   1840 N NE2 . GLN A 1 267 ? 180.74900 324.80400 12.25200  1.000 39.16912  ? 302 GLN F NE2 1 
ATOM   1841 N N   . LEU A 1 268 ? 175.64100 321.78400 13.29800  1.000 33.04468  ? 303 LEU F N   1 
ATOM   1842 C CA  . LEU A 1 268 ? 174.57300 322.28100 14.16600  1.000 33.23187  ? 303 LEU F CA  1 
ATOM   1843 C C   . LEU A 1 268 ? 175.10700 322.67800 15.54300  1.000 34.53340  ? 303 LEU F C   1 
ATOM   1844 O O   . LEU A 1 268 ? 176.04900 322.06600 16.05200  1.000 38.32551  ? 303 LEU F O   1 
ATOM   1845 C CB  . LEU A 1 268 ? 173.48800 321.22200 14.38500  1.000 29.33795  ? 303 LEU F CB  1 
ATOM   1846 C CG  . LEU A 1 268 ? 172.74000 320.67000 13.19100  1.000 30.67809  ? 303 LEU F CG  1 
ATOM   1847 C CD1 . LEU A 1 268 ? 171.56700 319.83400 13.66600  1.000 33.99034  ? 303 LEU F CD1 1 
ATOM   1848 C CD2 . LEU A 1 268 ? 172.29100 321.81400 12.35300  1.000 32.31096  ? 303 LEU F CD2 1 
ATOM   1849 N N   . PRO A 1 269 ? 174.52900 323.66400 16.21500  1.000 31.37286  ? 304 PRO F N   1 
ATOM   1850 C CA  . PRO A 1 269 ? 175.09800 324.11000 17.49200  1.000 32.21306  ? 304 PRO F CA  1 
ATOM   1851 C C   . PRO A 1 269 ? 174.79500 323.14400 18.62600  1.000 33.51283  ? 304 PRO F C   1 
ATOM   1852 O O   . PRO A 1 269 ? 173.70300 322.58200 18.71600  1.000 34.92483  ? 304 PRO F O   1 
ATOM   1853 C CB  . PRO A 1 269 ? 174.41600 325.45800 17.73000  1.000 27.41268  ? 304 PRO F CB  1 
ATOM   1854 C CG  . PRO A 1 269 ? 173.12700 325.32200 17.03200  1.000 30.11975  ? 304 PRO F CG  1 
ATOM   1855 C CD  . PRO A 1 269 ? 173.38700 324.48900 15.80800  1.000 30.62147  ? 304 PRO F CD  1 
ATOM   1856 N N   . LEU A 1 270 ? 175.76900 323.00000 19.52500  1.000 36.47511  ? 305 LEU F N   1 
ATOM   1857 C CA  . LEU A 1 270 ? 175.65400 322.26800 20.78300  1.000 32.75899  ? 305 LEU F CA  1 
ATOM   1858 C C   . LEU A 1 270 ? 175.75900 323.29200 21.89800  1.000 30.68935  ? 305 LEU F C   1 
ATOM   1859 O O   . LEU A 1 270 ? 176.78100 323.98400 22.02100  1.000 33.18771  ? 305 LEU F O   1 
ATOM   1860 C CB  . LEU A 1 270 ? 176.76600 321.23500 20.91000  1.000 33.57842  ? 305 LEU F CB  1 
ATOM   1861 C CG  . LEU A 1 270 ? 176.60900 319.99200 20.04100  1.000 40.65895  ? 305 LEU F CG  1 
ATOM   1862 C CD1 . LEU A 1 270 ? 177.72200 319.00800 20.28300  1.000 44.46311  ? 305 LEU F CD1 1 
ATOM   1863 C CD2 . LEU A 1 270 ? 175.25900 319.34300 20.32400  1.000 45.54442  ? 305 LEU F CD2 1 
ATOM   1864 N N   . TYR A 1 271 ? 174.72200 323.37000 22.72000  1.000 30.00904  ? 306 TYR F N   1 
ATOM   1865 C CA  . TYR A 1 271 ? 174.65700 324.37700 23.77400  1.000 33.40207  ? 306 TYR F CA  1 
ATOM   1866 C C   . TYR A 1 271 ? 175.14900 323.77200 25.08800  1.000 36.52639  ? 306 TYR F C   1 
ATOM   1867 O O   . TYR A 1 271 ? 174.37100 323.17000 25.83700  1.000 39.12850  ? 306 TYR F O   1 
ATOM   1868 C CB  . TYR A 1 271 ? 173.24100 324.93400 23.90200  1.000 30.94602  ? 306 TYR F CB  1 
ATOM   1869 C CG  . TYR A 1 271 ? 172.76700 325.59100 22.63300  1.000 27.09551  ? 306 TYR F CG  1 
ATOM   1870 C CD1 . TYR A 1 271 ? 173.15800 326.88500 22.30400  1.000 29.64261  ? 306 TYR F CD1 1 
ATOM   1871 C CD2 . TYR A 1 271 ? 171.86500 324.94500 21.80200  1.000 25.90253  ? 306 TYR F CD2 1 
ATOM   1872 C CE1 . TYR A 1 271 ? 172.72200 327.49200 21.13200  1.000 30.35270  ? 306 TYR F CE1 1 
ATOM   1873 C CE2 . TYR A 1 271 ? 171.41700 325.53300 20.64500  1.000 27.54699  ? 306 TYR F CE2 1 
ATOM   1874 C CZ  . TYR A 1 271 ? 171.83500 326.80700 20.32100  1.000 31.23306  ? 306 TYR F CZ  1 
ATOM   1875 O OH  . TYR A 1 271 ? 171.38500 327.39100 19.16400  1.000 30.51574  ? 306 TYR F OH  1 
ATOM   1876 N N   . GLY A 1 272 ? 176.46200 323.93400 25.35300  1.000 31.15106  ? 307 GLY F N   1 
ATOM   1877 C CA  . GLY A 1 272 ? 177.09300 323.47200 26.58500  1.000 29.29491  ? 307 GLY F CA  1 
ATOM   1878 C C   . GLY A 1 272 ? 176.72900 324.23000 27.85400  1.000 31.57644  ? 307 GLY F C   1 
ATOM   1879 O O   . GLY A 1 272 ? 176.88900 323.68700 28.94800  1.000 32.73331  ? 307 GLY F O   1 
ATOM   1880 N N   . VAL A 1 273 ? 176.25100 325.46200 27.75000  1.000 31.65015  ? 308 VAL F N   1 
ATOM   1881 C CA  . VAL A 1 273 ? 175.82500 326.22900 28.91300  1.000 28.33635  ? 308 VAL F CA  1 
ATOM   1882 C C   . VAL A 1 273 ? 174.31800 326.38800 28.85000  1.000 28.56222  ? 308 VAL F C   1 
ATOM   1883 O O   . VAL A 1 273 ? 173.80000 326.94100 27.87200  1.000 31.99789  ? 308 VAL F O   1 
ATOM   1884 C CB  . VAL A 1 273 ? 176.51800 327.59500 28.97200  1.000 28.45827  ? 308 VAL F CB  1 
ATOM   1885 C CG1 . VAL A 1 273 ? 176.38000 328.19900 30.35700  1.000 33.85783  ? 308 VAL F CG1 1 
ATOM   1886 C CG2 . VAL A 1 273 ? 177.97800 327.42800 28.64600  1.000 24.00633  ? 308 VAL F CG2 1 
ATOM   1887 N N   . ILE A 1 274 ? 173.61100 325.83300 29.83700  1.000 30.77976  ? 309 ILE F N   1 
ATOM   1888 C CA  . ILE A 1 274 ? 172.15200 325.89200 29.88100  1.000 31.50813  ? 309 ILE F CA  1 
ATOM   1889 C C   . ILE A 1 274 ? 171.59900 326.33900 31.23300  1.000 32.67477  ? 309 ILE F C   1 
ATOM   1890 O O   . ILE A 1 274 ? 172.11600 325.97500 32.29800  1.000 33.79224  ? 309 ILE F O   1 
ATOM   1891 C CB  . ILE A 1 274 ? 171.52100 324.54700 29.48400  1.000 30.35592  ? 309 ILE F CB  1 
ATOM   1892 C CG1 . ILE A 1 274 ? 171.97900 324.16900 28.07300  1.000 37.94114  ? 309 ILE F CG1 1 
ATOM   1893 C CG2 . ILE A 1 274 ? 170.03000 324.59200 29.66500  1.000 29.34689  ? 309 ILE F CG2 1 
ATOM   1894 C CD1 . ILE A 1 274 ? 171.32400 324.99500 26.97700  1.000 34.31692  ? 309 ILE F CD1 1 
ATOM   1895 N N   . ASP A 1 275 ? 170.54700 327.17000 31.20000  1.000 32.81437  ? 310 ASP F N   1 
ATOM   1896 C CA  . ASP A 1 275 ? 169.76400 327.57400 32.40200  1.000 33.53190  ? 310 ASP F CA  1 
ATOM   1897 C C   . ASP A 1 275 ? 170.60600 328.34300 33.39800  1.000 33.79437  ? 310 ASP F C   1 
ATOM   1898 O O   . ASP A 1 275 ? 170.30900 328.30200 34.58800  1.000 34.41358  ? 310 ASP F O   1 
ATOM   1899 C CB  . ASP A 1 275 ? 168.92100 326.42600 32.95800  1.000 38.75834  ? 310 ASP F CB  1 
ATOM   1900 C CG  . ASP A 1 275 ? 167.54600 326.29100 32.34100  1.000 43.97313  ? 310 ASP F CG  1 
ATOM   1901 O OD1 . ASP A 1 275 ? 167.47500 326.02100 31.14100  1.000 40.68345  ? 310 ASP F OD1 1 
ATOM   1902 O OD2 . ASP A 1 275 ? 166.56100 326.43000 33.08000  1.000 58.10283  ? 310 ASP F OD2 1 
ATOM   1903 N N   . THR A 1 276 ? 171.58400 329.06100 32.89000  1.000 34.38428  ? 311 THR F N   1 
ATOM   1904 C CA  . THR A 1 276 ? 172.41200 329.90700 33.75800  1.000 30.72686  ? 311 THR F CA  1 
ATOM   1905 C C   . THR A 1 276 ? 171.77500 331.29200 33.81600  1.000 32.85839  ? 311 THR F C   1 
ATOM   1906 O O   . THR A 1 276 ? 170.97700 331.61600 32.92600  1.000 31.75424  ? 311 THR F O   1 
ATOM   1907 C CB  . THR A 1 276 ? 173.79900 330.00900 33.14200  1.000 28.90217  ? 311 THR F CB  1 
ATOM   1908 O OG1 . THR A 1 276 ? 174.76800 329.81700 34.16900  1.000 39.05955  ? 311 THR F OG1 1 
ATOM   1909 C CG2 . THR A 1 276 ? 173.97300 331.34400 32.46300  1.000 33.81495  ? 311 THR F CG2 1 
ATOM   1910 N N   . PRO A 1 277 ? 171.99500 332.07900 34.88500  1.000 31.68069  ? 312 PRO F N   1 
ATOM   1911 C CA  . PRO A 1 277 ? 171.50900 333.44900 34.90900  1.000 29.64182  ? 312 PRO F CA  1 
ATOM   1912 C C   . PRO A 1 277 ? 172.12500 334.38600 33.85600  1.000 29.08473  ? 312 PRO F C   1 
ATOM   1913 O O   . PRO A 1 277 ? 173.31700 334.40600 33.71800  1.000 28.34994  ? 312 PRO F O   1 
ATOM   1914 C CB  . PRO A 1 277 ? 171.85900 333.87000 36.33500  1.000 24.89445  ? 312 PRO F CB  1 
ATOM   1915 C CG  . PRO A 1 277 ? 171.89100 332.58500 37.10500  1.000 28.70536  ? 312 PRO F CG  1 
ATOM   1916 C CD  . PRO A 1 277 ? 172.59000 331.65400 36.14700  1.000 30.39808  ? 312 PRO F CD  1 
ATOM   1917 N N   . CYS A 1 278 ? 171.28500 335.14600 33.15300  1.000 29.57356  ? 313 CYS F N   1 
ATOM   1918 C CA  . CYS A 1 278 ? 171.76500 336.09300 32.16200  1.000 29.15129  ? 313 CYS F CA  1 
ATOM   1919 C C   . CYS A 1 278 ? 171.08800 337.42400 32.47000  1.000 30.92648  ? 313 CYS F C   1 
ATOM   1920 O O   . CYS A 1 278 ? 169.92000 337.44500 32.88200  1.000 31.56401  ? 313 CYS F O   1 
ATOM   1921 C CB  . CYS A 1 278 ? 171.38100 335.66300 30.75000  1.000 24.90851  ? 313 CYS F CB  1 
ATOM   1922 S SG  . CYS A 1 278 ? 172.23600 334.25700 30.13400  1.000 30.12527  ? 313 CYS F SG  1 
ATOM   1923 N N   . TRP A 1 279 ? 171.84700 338.52600 32.35000  1.000 27.26991  ? 314 TRP F N   1 
ATOM   1924 C CA  . TRP A 1 279 ? 171.30200 339.88000 32.47100  1.000 27.88264  ? 314 TRP F CA  1 
ATOM   1925 C C   . TRP A 1 279 ? 171.79800 340.76300 31.32200  1.000 26.63802  ? 314 TRP F C   1 
ATOM   1926 O O   . TRP A 1 279 ? 172.80600 340.48100 30.67200  1.000 25.59074  ? 314 TRP F O   1 
ATOM   1927 C CB  . TRP A 1 279 ? 171.63900 340.52000 33.84900  1.000 28.39439  ? 314 TRP F CB  1 
ATOM   1928 C CG  . TRP A 1 279 ? 173.11700 340.63900 34.14300  1.000 25.77626  ? 314 TRP F CG  1 
ATOM   1929 C CD1 . TRP A 1 279 ? 173.88600 341.75300 34.02100  1.000 26.52525  ? 314 TRP F CD1 1 
ATOM   1930 C CD2 . TRP A 1 279 ? 173.99700 339.59300 34.56800  1.000 28.00601  ? 314 TRP F CD2 1 
ATOM   1931 N NE1 . TRP A 1 279 ? 175.19200 341.48000 34.36200  1.000 29.85682  ? 314 TRP F NE1 1 
ATOM   1932 C CE2 . TRP A 1 279 ? 175.29000 340.15700 34.69400  1.000 29.61767  ? 314 TRP F CE2 1 
ATOM   1933 C CE3 . TRP A 1 279 ? 173.81800 338.23700 34.86800  1.000 26.52092  ? 314 TRP F CE3 1 
ATOM   1934 C CZ2 . TRP A 1 279 ? 176.39900 339.41200 35.11700  1.000 26.92467  ? 314 TRP F CZ2 1 
ATOM   1935 C CZ3 . TRP A 1 279 ? 174.91600 337.49700 35.28500  1.000 26.56975  ? 314 TRP F CZ3 1 
ATOM   1936 C CH2 . TRP A 1 279 ? 176.19200 338.08600 35.40100  1.000 28.42343  ? 314 TRP F CH2 1 
ATOM   1937 N N   . LYS A 1 280 ? 171.05400 341.83500 31.03700  1.000 24.75734  ? 315 LYS F N   1 
ATOM   1938 C CA  . LYS A 1 280 ? 171.45000 342.77600 29.98300  1.000 27.04696  ? 315 LYS F CA  1 
ATOM   1939 C C   . LYS A 1 280 ? 171.72800 344.14500 30.58100  1.000 27.11148  ? 315 LYS F C   1 
ATOM   1940 O O   . LYS A 1 280 ? 170.87100 344.68600 31.29200  1.000 25.79476  ? 315 LYS F O   1 
ATOM   1941 C CB  . LYS A 1 280 ? 170.39200 342.90500 28.88700  1.000 24.54882  ? 315 LYS F CB  1 
ATOM   1942 C CG  . LYS A 1 280 ? 170.86400 343.72400 27.67700  1.000 25.04648  ? 315 LYS F CG  1 
ATOM   1943 C CD  . LYS A 1 280 ? 169.92300 343.64400 26.46300  1.000 26.77472  ? 315 LYS F CD  1 
ATOM   1944 C CE  . LYS A 1 280 ? 170.52600 344.32100 25.22700  1.000 26.70951  ? 315 LYS F CE  1 
ATOM   1945 N NZ  . LYS A 1 280 ? 169.67400 344.19300 24.01000  1.000 25.80935  ? 315 LYS F NZ  1 
ATOM   1946 N N   . LEU A 1 281 ? 172.95200 344.65900 30.36500  1.000 25.71662  ? 316 LEU F N   1 
ATOM   1947 C CA  . LEU A 1 281 ? 173.35400 345.96900 30.86900  1.000 24.13667  ? 316 LEU F CA  1 
ATOM   1948 C C   . LEU A 1 281 ? 173.06800 347.02600 29.80100  1.000 28.99781  ? 316 LEU F C   1 
ATOM   1949 O O   . LEU A 1 281 ? 173.49500 346.88100 28.63500  1.000 26.44173  ? 316 LEU F O   1 
ATOM   1950 C CB  . LEU A 1 281 ? 174.82700 345.97600 31.23300  1.000 24.01294  ? 316 LEU F CB  1 
ATOM   1951 C CG  . LEU A 1 281 ? 175.42900 347.31800 31.60800  1.000 25.84361  ? 316 LEU F CG  1 
ATOM   1952 C CD1 . LEU A 1 281 ? 174.75800 347.86200 32.83800  1.000 25.33564  ? 316 LEU F CD1 1 
ATOM   1953 C CD2 . LEU A 1 281 ? 176.89200 347.09900 31.92200  1.000 28.98456  ? 316 LEU F CD2 1 
ATOM   1954 N N   . HIS A 1 282 ? 172.37000 348.10100 30.21400  1.000 31.14756  ? 317 HIS F N   1 
ATOM   1955 C CA  . HIS A 1 282 ? 172.05400 349.24700 29.37500  1.000 25.30665  ? 317 HIS F CA  1 
ATOM   1956 C C   . HIS A 1 282 ? 172.71100 350.49800 29.94200  1.000 26.05751  ? 317 HIS F C   1 
ATOM   1957 O O   . HIS A 1 282 ? 172.57700 350.78500 31.14100  1.000 27.36601  ? 317 HIS F O   1 
ATOM   1958 C CB  . HIS A 1 282 ? 170.54200 349.45600 29.36300  1.000 24.51820  ? 317 HIS F CB  1 
ATOM   1959 C CG  . HIS A 1 282 ? 169.75700 348.23700 28.97100  1.000 28.76440  ? 317 HIS F CG  1 
ATOM   1960 N ND1 . HIS A 1 282 ? 169.40200 347.95100 27.66600  1.000 32.09802  ? 317 HIS F ND1 1 
ATOM   1961 C CD2 . HIS A 1 282 ? 169.17300 347.28100 29.73600  1.000 26.09080  ? 317 HIS F CD2 1 
ATOM   1962 C CE1 . HIS A 1 282 ? 168.69100 346.83500 27.63800  1.000 27.51864  ? 317 HIS F CE1 1 
ATOM   1963 N NE2 . HIS A 1 282 ? 168.52900 346.41400 28.88200  1.000 28.57879  ? 317 HIS F NE2 1 
ATOM   1964 N N   . THR A 1 283 ? 173.37400 351.27100 29.08700  1.000 28.17694  ? 318 THR F N   1 
ATOM   1965 C CA  . THR A 1 283 ? 174.07700 352.47000 29.53000  1.000 26.72527  ? 318 THR F CA  1 
ATOM   1966 C C   . THR A 1 283 ? 173.65700 353.69000 28.71200  1.000 24.19736  ? 318 THR F C   1 
ATOM   1967 O O   . THR A 1 283 ? 173.32200 353.58200 27.53300  1.000 27.56489  ? 318 THR F O   1 
ATOM   1968 C CB  . THR A 1 283 ? 175.56600 352.24900 29.44000  1.000 26.60959  ? 318 THR F CB  1 
ATOM   1969 O OG1 . THR A 1 283 ? 175.90400 352.06700 28.06200  1.000 29.39899  ? 318 THR F OG1 1 
ATOM   1970 C CG2 . THR A 1 283 ? 175.94600 351.02400 30.22800  1.000 25.29244  ? 318 THR F CG2 1 
ATOM   1971 N N   . SER A 1 284 ? 173.75400 354.86600 29.32200  1.000 22.02955  ? 319 SER F N   1 
ATOM   1972 C CA  . SER A 1 284 ? 173.37100 356.11100 28.67300  1.000 23.58726  ? 319 SER F CA  1 
ATOM   1973 C C   . SER A 1 284 ? 174.23400 357.23800 29.22100  1.000 21.81805  ? 319 SER F C   1 
ATOM   1974 O O   . SER A 1 284 ? 174.73200 357.11600 30.34200  1.000 22.86006  ? 319 SER F O   1 
ATOM   1975 C CB  . SER A 1 284 ? 171.88300 356.39400 28.91200  1.000 24.86137  ? 319 SER F CB  1 
ATOM   1976 O OG  . SER A 1 284 ? 171.42000 357.42500 28.07900  1.000 25.77263  ? 319 SER F OG  1 
ATOM   1977 N N   . PRO A 1 285 ? 174.50800 358.29100 28.44000  1.000 21.88402  ? 320 PRO F N   1 
ATOM   1978 C CA  . PRO A 1 285 ? 175.38800 359.36600 28.92900  1.000 21.55758  ? 320 PRO F CA  1 
ATOM   1979 C C   . PRO A 1 285 ? 174.82100 360.06400 30.15400  1.000 23.26151  ? 320 PRO F C   1 
ATOM   1980 O O   . PRO A 1 285 ? 173.64000 360.40200 30.19100  1.000 26.24651  ? 320 PRO F O   1 
ATOM   1981 C CB  . PRO A 1 285 ? 175.45000 360.32400 27.74700  1.000 23.32701  ? 320 PRO F CB  1 
ATOM   1982 C CG  . PRO A 1 285 ? 175.16700 359.50600 26.59600  1.000 25.04952  ? 320 PRO F CG  1 
ATOM   1983 C CD  . PRO A 1 285 ? 174.17500 358.48200 27.02500  1.000 23.17013  ? 320 PRO F CD  1 
ATOM   1984 N N   . LEU A 1 286 ? 175.69900 360.33100 31.13300  1.000 27.04037  ? 321 LEU F N   1 
ATOM   1985 C CA  . LEU A 1 286 ? 175.39600 361.00400 32.40700  1.000 25.56074  ? 321 LEU F CA  1 
ATOM   1986 C C   . LEU A 1 286 ? 176.21000 362.29900 32.50800  1.000 30.48177  ? 321 LEU F C   1 
ATOM   1987 O O   . LEU A 1 286 ? 177.42200 362.26500 32.73600  1.000 31.90028  ? 321 LEU F O   1 
ATOM   1988 C CB  . LEU A 1 286 ? 175.70300 360.07600 33.56700  1.000 27.49033  ? 321 LEU F CB  1 
ATOM   1989 C CG  . LEU A 1 286 ? 175.40000 360.62900 34.96000  1.000 30.94116  ? 321 LEU F CG  1 
ATOM   1990 C CD1 . LEU A 1 286 ? 173.90900 360.76700 35.16400  1.000 30.68375  ? 321 LEU F CD1 1 
ATOM   1991 C CD2 . LEU A 1 286 ? 176.03200 359.78400 36.05500  1.000 27.70695  ? 321 LEU F CD2 1 
ATOM   1992 N N   . CYS A 1 287 ? 175.58300 363.43200 32.23600  1.000 32.79279  ? 322 CYS F N   1 
ATOM   1993 C CA  . CYS A 1 287 ? 176.24100 364.73200 32.22400  1.000 29.88690  ? 322 CYS F CA  1 
ATOM   1994 C C   . CYS A 1 287 ? 175.75800 365.65000 33.33800  1.000 31.73055  ? 322 CYS F C   1 
ATOM   1995 O O   . CYS A 1 287 ? 174.72100 365.42400 33.96700  1.000 33.80619  ? 322 CYS F O   1 
ATOM   1996 C CB  . CYS A 1 287 ? 176.00400 365.41300 30.88000  1.000 32.78090  ? 322 CYS F CB  1 
ATOM   1997 S SG  . CYS A 1 287 ? 176.45500 364.39000 29.51400  1.000 37.34658  ? 322 CYS F SG  1 
ATOM   1998 N N   . THR A 1 288 ? 176.50100 366.73700 33.53800  1.000 36.19004  ? 323 THR F N   1 
ATOM   1999 C CA  . THR A 1 288 ? 176.00100 367.74200 34.45600  1.000 37.62981  ? 323 THR F CA  1 
ATOM   2000 C C   . THR A 1 288 ? 175.06200 368.66400 33.67800  1.000 41.10734  ? 323 THR F C   1 
ATOM   2001 O O   . THR A 1 288 ? 175.11900 368.77000 32.44200  1.000 41.11442  ? 323 THR F O   1 
ATOM   2002 C CB  . THR A 1 288 ? 177.15400 368.54000 35.10900  1.000 34.15913  ? 323 THR F CB  1 
ATOM   2003 O OG1 . THR A 1 288 ? 178.02100 369.09400 34.11100  1.000 37.63735  ? 323 THR F OG1 1 
ATOM   2004 C CG2 . THR A 1 288 ? 177.95600 367.69300 36.03000  1.000 29.75065  ? 323 THR F CG2 1 
ATOM   2005 N N   . THR A 1 289 ? 174.20500 369.35100 34.42800  1.000 42.80303  ? 324 THR F N   1 
ATOM   2006 C CA  . THR A 1 289 ? 173.12500 370.15100 33.85900  1.000 45.25870  ? 324 THR F CA  1 
ATOM   2007 C C   . THR A 1 289 ? 173.32200 371.61700 34.19700  1.000 52.07423  ? 324 THR F C   1 
ATOM   2008 O O   . THR A 1 289 ? 172.39200 372.29000 34.65300  1.000 56.05235  ? 324 THR F O   1 
ATOM   2009 C CB  . THR A 1 289 ? 171.76600 369.61500 34.31200  1.000 44.83395  ? 324 THR F CB  1 
ATOM   2010 O OG1 . THR A 1 289 ? 171.66700 369.61600 35.74500  1.000 51.90735  ? 324 THR F OG1 1 
ATOM   2011 C CG2 . THR A 1 289 ? 171.60400 368.18700 33.79400  1.000 37.13692  ? 324 THR F CG2 1 
ATOM   2012 N N   . ASN A 1 290 ? 174.53100 372.11200 33.97800  1.000 56.28185  ? 325 ASN F N   1 
ATOM   2013 C CA  . ASN A 1 290 ? 174.76500 373.53000 34.13500  1.000 61.55536  ? 325 ASN F CA  1 
ATOM   2014 C C   . ASN A 1 290 ? 174.13400 374.29100 32.97500  1.000 69.55961  ? 325 ASN F C   1 
ATOM   2015 O O   . ASN A 1 290 ? 173.96100 373.77000 31.86100  1.000 62.22745  ? 325 ASN F O   1 
ATOM   2016 C CB  . ASN A 1 290 ? 176.25900 373.81100 34.21500  1.000 57.48271  ? 325 ASN F CB  1 
ATOM   2017 C CG  . ASN A 1 290 ? 176.75800 373.72300 35.61900  1.000 56.16576  ? 325 ASN F CG  1 
ATOM   2018 O OD1 . ASN A 1 290 ? 175.96400 373.66200 36.55200  1.000 55.37329  ? 325 ASN F OD1 1 
ATOM   2019 N ND2 . ASN A 1 290 ? 178.06900 373.69800 35.78900  1.000 58.93020  ? 325 ASN F ND2 1 
ATOM   2020 N N   . THR A 1 291 ? 173.88300 375.57700 33.22800  1.000 76.75979  ? 326 THR F N   1 
ATOM   2021 C CA  . THR A 1 291 ? 173.12200 376.40900 32.31100  1.000 78.29366  ? 326 THR F CA  1 
ATOM   2022 C C   . THR A 1 291 ? 173.99500 377.08000 31.26000  1.000 83.95968  ? 326 THR F C   1 
ATOM   2023 O O   . THR A 1 291 ? 173.45500 377.63700 30.29600  1.000 87.83951  ? 326 THR F O   1 
ATOM   2024 C CB  . THR A 1 291 ? 172.30900 377.44600 33.11600  1.000 74.10320  ? 326 THR F CB  1 
ATOM   2025 O OG1 . THR A 1 291 ? 171.44200 378.17300 32.24100  1.000 82.44932  ? 326 THR F OG1 1 
ATOM   2026 C CG2 . THR A 1 291 ? 173.22200 378.42100 33.85300  1.000 72.62684  ? 326 THR F CG2 1 
ATOM   2027 N N   . LYS A 1 292 ? 175.32000 376.94500 31.35900  1.000 85.58805  ? 327 LYS F N   1 
ATOM   2028 C CA  . LYS A 1 292 ? 176.24800 377.55300 30.41100  1.000 85.58004  ? 327 LYS F CA  1 
ATOM   2029 C C   . LYS A 1 292 ? 176.90400 376.39000 29.67500  1.000 87.28145  ? 327 LYS F C   1 
ATOM   2030 O O   . LYS A 1 292 ? 177.63800 375.59600 30.27800  1.000 85.46664  ? 327 LYS F O   1 
ATOM   2031 C CB  . LYS A 1 292 ? 177.28700 378.40800 31.13500  1.000 81.99170  ? 327 LYS F CB  1 
ATOM   2032 C CG  . LYS A 1 292 ? 178.27000 379.10300 30.19800  1.000 89.00207  ? 327 LYS F CG  1 
ATOM   2033 C CD  . LYS A 1 292 ? 179.71800 378.73900 30.51200  1.000 92.14281  ? 327 LYS F CD  1 
ATOM   2034 C CE  . LYS A 1 292 ? 180.56600 378.67300 29.23000  1.000 89.28866  ? 327 LYS F CE  1 
ATOM   2035 N NZ  . LYS A 1 292 ? 182.03700 378.53300 29.46900  1.000 85.95092  ? 327 LYS F NZ  1 
ATOM   2036 N N   . GLU A 1 293 ? 176.64400 376.30200 28.37000  1.000 90.78800  ? 328 GLU F N   1 
ATOM   2037 C CA  . GLU A 1 293 ? 177.19600 375.23600 27.53400  1.000 99.30569  ? 328 GLU F CA  1 
ATOM   2038 C C   . GLU A 1 293 ? 178.70600 375.35500 27.33200  1.000 97.05972  ? 328 GLU F C   1 
ATOM   2039 O O   . GLU A 1 293 ? 179.23400 376.46100 27.18000  1.000 98.44094  ? 328 GLU F O   1 
ATOM   2040 C CB  . GLU A 1 293 ? 176.48300 375.22600 26.17500  1.000 104.39823 ? 328 GLU F CB  1 
ATOM   2041 C CG  . GLU A 1 293 ? 174.95200 375.03000 26.24700  1.000 109.88307 ? 328 GLU F CG  1 
ATOM   2042 C CD  . GLU A 1 293 ? 174.52600 373.76200 27.01300  1.000 107.05785 ? 328 GLU F CD  1 
ATOM   2043 O OE1 . GLU A 1 293 ? 174.39200 372.68900 26.37100  1.000 101.49271 ? 328 GLU F OE1 1 
ATOM   2044 O OE2 . GLU A 1 293 ? 174.32500 373.83900 28.25300  1.000 95.27819  ? 328 GLU F OE2 1 
ATOM   2045 N N   . GLY A 1 294 ? 179.41600 374.20300 27.35900  1.000 86.44914  ? 329 GLY F N   1 
ATOM   2046 C CA  . GLY A 1 294 ? 180.86700 374.21700 27.40200  1.000 79.10544  ? 329 GLY F CA  1 
ATOM   2047 C C   . GLY A 1 294 ? 181.46700 374.06700 28.77500  1.000 71.17784  ? 329 GLY F C   1 
ATOM   2048 O O   . GLY A 1 294 ? 182.69400 373.93500 28.89800  1.000 77.75562  ? 329 GLY F O   1 
ATOM   2049 N N   . SER A 1 295 ? 180.63400 374.05600 29.80000  1.000 66.04534  ? 330 SER F N   1 
ATOM   2050 C CA  . SER A 1 295 ? 181.04300 373.89000 31.18500  1.000 69.15609  ? 330 SER F CA  1 
ATOM   2051 C C   . SER A 1 295 ? 180.52500 372.58600 31.74700  1.000 64.06457  ? 330 SER F C   1 
ATOM   2052 O O   . SER A 1 295 ? 180.52600 372.38700 32.96800  1.000 57.22843  ? 330 SER F O   1 
ATOM   2053 C CB  . SER A 1 295 ? 180.54400 375.06200 32.03700  1.000 75.47788  ? 330 SER F CB  1 
ATOM   2054 O OG  . SER A 1 295 ? 179.12000 375.11500 32.09200  1.000 69.73345  ? 330 SER F OG  1 
ATOM   2055 N N   . ASN A 1 296 ? 180.15200 371.66200 30.87400  1.000 62.20137  ? 331 ASN F N   1 
ATOM   2056 C CA  . ASN A 1 296 ? 179.54200 370.44200 31.34000  1.000 51.57542  ? 331 ASN F CA  1 
ATOM   2057 C C   . ASN A 1 296 ? 180.45600 369.26500 31.04200  1.000 44.72522  ? 331 ASN F C   1 
ATOM   2058 O O   . ASN A 1 296 ? 181.12600 369.22200 30.00900  1.000 42.76502  ? 331 ASN F O   1 
ATOM   2059 C CB  . ASN A 1 296 ? 178.22800 370.25600 30.59000  1.000 48.47357  ? 331 ASN F CB  1 
ATOM   2060 C CG  . ASN A 1 296 ? 177.12900 371.07300 31.17300  1.000 48.35097  ? 331 ASN F CG  1 
ATOM   2061 O OD1 . ASN A 1 296 ? 176.95500 371.12900 32.38800  1.000 45.18523  ? 331 ASN F OD1 1 
ATOM   2062 N ND2 . ASN A 1 296 ? 176.34600 371.68800 30.30300  1.000 52.66420  ? 331 ASN F ND2 1 
ATOM   2063 N N   . ILE A 1 297 ? 180.43600 368.28400 31.94000  1.000 41.54126  ? 332 ILE F N   1 
ATOM   2064 C CA  . ILE A 1 297 ? 181.25400 367.09200 31.77800  1.000 40.72509  ? 332 ILE F CA  1 
ATOM   2065 C C   . ILE A 1 297 ? 180.37400 365.85300 31.76100  1.000 38.66711  ? 332 ILE F C   1 
ATOM   2066 O O   . ILE A 1 297 ? 179.36400 365.77300 32.46100  1.000 36.76875  ? 332 ILE F O   1 
ATOM   2067 C CB  . ILE A 1 297 ? 182.25500 367.02500 32.94200  1.000 37.98170  ? 332 ILE F CB  1 
ATOM   2068 C CG1 . ILE A 1 297 ? 181.46700 367.06500 34.25000  1.000 33.79683  ? 332 ILE F CG1 1 
ATOM   2069 C CG2 . ILE A 1 297 ? 183.21900 368.17300 32.86000  1.000 45.87010  ? 332 ILE F CG2 1 
ATOM   2070 C CD1 . ILE A 1 297 ? 182.29600 367.01200 35.45800  1.000 34.88975  ? 332 ILE F CD1 1 
ATOM   2071 N N   . CYS A 1 298 ? 180.78100 364.85400 30.98200  1.000 41.89186  ? 333 CYS F N   1 
ATOM   2072 C CA  . CYS A 1 298 ? 179.92200 363.66100 30.80200  1.000 40.10648  ? 333 CYS F CA  1 
ATOM   2073 C C   . CYS A 1 298 ? 180.66500 362.36900 31.13200  1.000 40.31485  ? 333 CYS F C   1 
ATOM   2074 O O   . CYS A 1 298 ? 181.88600 362.34900 30.99900  1.000 35.38730  ? 333 CYS F O   1 
ATOM   2075 C CB  . CYS A 1 298 ? 179.33900 363.62200 29.39600  1.000 37.65168  ? 333 CYS F CB  1 
ATOM   2076 S SG  . CYS A 1 298 ? 178.29300 365.04200 29.00000  1.000 49.79401  ? 333 CYS F SG  1 
ATOM   2077 N N   . LEU A 1 299 ? 179.92300 361.34000 31.52800  1.000 39.36247  ? 334 LEU F N   1 
ATOM   2078 C CA  . LEU A 1 299 ? 180.48600 360.02900 31.92400  1.000 31.03060  ? 334 LEU F CA  1 
ATOM   2079 C C   . LEU A 1 299 ? 179.50900 358.99500 31.38000  1.000 34.04611  ? 334 LEU F C   1 
ATOM   2080 O O   . LEU A 1 299 ? 178.31400 359.23200 31.48000  1.000 32.22198  ? 334 LEU F O   1 
ATOM   2081 C CB  . LEU A 1 299 ? 180.45700 360.03500 33.45500  1.000 28.54187  ? 334 LEU F CB  1 
ATOM   2082 C CG  . LEU A 1 299 ? 180.93800 358.82000 34.23600  1.000 31.60028  ? 334 LEU F CG  1 
ATOM   2083 C CD1 . LEU A 1 299 ? 181.58300 359.29900 35.52400  1.000 29.57869  ? 334 LEU F CD1 1 
ATOM   2084 C CD2 . LEU A 1 299 ? 179.77700 357.89600 34.56600  1.000 28.70971  ? 334 LEU F CD2 1 
ATOM   2085 N N   . THR A 1 300 ? 180.00100 357.91300 30.79300  1.000 33.70856  ? 335 THR F N   1 
ATOM   2086 C CA  . THR A 1 300 ? 179.10400 356.82100 30.34800  1.000 29.54213  ? 335 THR F CA  1 
ATOM   2087 C C   . THR A 1 300 ? 179.73400 355.48800 30.72200  1.000 30.98922  ? 335 THR F C   1 
ATOM   2088 O O   . THR A 1 300 ? 180.91700 355.32600 30.45700  1.000 30.30387  ? 335 THR F O   1 
ATOM   2089 C CB  . THR A 1 300 ? 178.78800 356.87100 28.84600  1.000 28.47225  ? 335 THR F CB  1 
ATOM   2090 O OG1 . THR A 1 300 ? 178.47100 358.19800 28.43200  1.000 31.09915  ? 335 THR F OG1 1 
ATOM   2091 C CG2 . THR A 1 300 ? 177.68600 355.92400 28.42800  1.000 25.58930  ? 335 THR F CG2 1 
ATOM   2092 N N   . ARG A 1 301 ? 178.96700 354.59100 31.34100  1.000 29.11561  ? 336 ARG F N   1 
ATOM   2093 C CA  . ARG A 1 301 ? 179.44800 353.23300 31.59100  1.000 32.39960  ? 336 ARG F CA  1 
ATOM   2094 C C   . ARG A 1 301 ? 179.66700 352.51600 30.27500  1.000 32.65831  ? 336 ARG F C   1 
ATOM   2095 O O   . ARG A 1 301 ? 178.85400 352.62400 29.34900  1.000 31.26590  ? 336 ARG F O   1 
ATOM   2096 C CB  . ARG A 1 301 ? 178.49900 352.42200 32.47400  1.000 28.06519  ? 336 ARG F CB  1 
ATOM   2097 C CG  . ARG A 1 301 ? 178.47500 352.84100 33.92200  1.000 24.95211  ? 336 ARG F CG  1 
ATOM   2098 C CD  . ARG A 1 301 ? 177.56800 351.92700 34.67900  1.000 25.80538  ? 336 ARG F CD  1 
ATOM   2099 N NE  . ARG A 1 301 ? 177.97400 350.53800 34.59300  1.000 28.29468  ? 336 ARG F NE  1 
ATOM   2100 C CZ  . ARG A 1 301 ? 177.30000 349.54500 35.15100  1.000 30.08805  ? 336 ARG F CZ  1 
ATOM   2101 N NH1 . ARG A 1 301 ? 176.18500 349.77000 35.82800  1.000 28.07156  ? 336 ARG F NH1 1 
ATOM   2102 N NH2 . ARG A 1 301 ? 177.77100 348.29900 35.04700  1.000 33.20738  ? 336 ARG F NH2 1 
ATOM   2103 N N   . THR A 1 302 ? 180.70400 351.68400 30.23100  1.000 35.22348  ? 337 THR F N   1 
ATOM   2104 C CA  . THR A 1 302 ? 181.02900 350.96800 29.01000  1.000 36.86262  ? 337 THR F CA  1 
ATOM   2105 C C   . THR A 1 302 ? 180.63500 349.50200 29.12600  1.000 36.65936  ? 337 THR F C   1 
ATOM   2106 O O   . THR A 1 302 ? 180.10400 349.03100 30.14500  1.000 33.31467  ? 337 THR F O   1 
ATOM   2107 C CB  . THR A 1 302 ? 182.53100 351.07100 28.73500  1.000 38.59323  ? 337 THR F CB  1 
ATOM   2108 O OG1 . THR A 1 302 ? 183.28200 350.59100 29.86600  1.000 38.42611  ? 337 THR F OG1 1 
ATOM   2109 C CG2 . THR A 1 302 ? 182.90100 352.50100 28.50200  1.000 40.68114  ? 337 THR F CG2 1 
ATOM   2110 N N   . ASP A 1 303 ? 180.87600 348.77500 28.03900  1.000 35.85873  ? 338 ASP F N   1 
ATOM   2111 C CA  . ASP A 1 303 ? 180.58000 347.34500 27.99000  1.000 35.42900  ? 338 ASP F CA  1 
ATOM   2112 C C   . ASP A 1 303 ? 179.08500 347.09100 28.23700  1.000 33.38552  ? 338 ASP F C   1 
ATOM   2113 O O   . ASP A 1 303 ? 178.68000 346.31400 29.09600  1.000 32.22516  ? 338 ASP F O   1 
ATOM   2114 C CB  . ASP A 1 303 ? 181.46600 346.61100 29.01300  1.000 37.56587  ? 338 ASP F CB  1 
ATOM   2115 C CG  . ASP A 1 303 ? 182.96900 346.76600 28.71500  1.000 42.73874  ? 338 ASP F CG  1 
ATOM   2116 O OD1 . ASP A 1 303 ? 183.32600 346.90100 27.52800  1.000 44.57828  ? 338 ASP F OD1 1 
ATOM   2117 O OD2 . ASP A 1 303 ? 183.78900 346.79200 29.67500  1.000 48.44729  ? 338 ASP F OD2 1 
ATOM   2118 N N   . ARG A 1 304 ? 178.26600 347.69500 27.39900  1.000 31.60620  ? 339 ARG F N   1 
ATOM   2119 C CA  . ARG A 1 304 ? 176.85700 347.41000 27.47800  1.000 24.93434  ? 339 ARG F CA  1 
ATOM   2120 C C   . ARG A 1 304 ? 176.58300 346.17600 26.64000  1.000 24.87629  ? 339 ARG F C   1 
ATOM   2121 O O   . ARG A 1 304 ? 177.29400 345.89000 25.67100  1.000 27.83630  ? 339 ARG F O   1 
ATOM   2122 C CB  . ARG A 1 304 ? 176.04100 348.60700 26.95200  1.000 25.09752  ? 339 ARG F CB  1 
ATOM   2123 C CG  . ARG A 1 304 ? 176.29700 348.98700 25.40800  1.000 23.63314  ? 339 ARG F CG  1 
ATOM   2124 C CD  . ARG A 1 304 ? 175.23000 349.90100 24.85200  1.000 29.30120  ? 339 ARG F CD  1 
ATOM   2125 N NE  . ARG A 1 304 ? 175.40500 351.24000 25.39900  1.000 40.26985  ? 339 ARG F NE  1 
ATOM   2126 C CZ  . ARG A 1 304 ? 175.95500 352.27000 24.77700  1.000 36.25443  ? 339 ARG F CZ  1 
ATOM   2127 N NH1 . ARG A 1 304 ? 176.41000 352.17000 23.53700  1.000 36.05673  ? 339 ARG F NH1 1 
ATOM   2128 N NH2 . ARG A 1 304 ? 176.06800 353.42200 25.42800  1.000 35.91904  ? 339 ARG F NH2 1 
ATOM   2129 N N   . GLY A 1 305 ? 175.62100 345.39100 27.08300  1.000 27.49425  ? 340 GLY F N   1 
ATOM   2130 C CA  . GLY A 1 305 ? 175.30500 344.18700 26.33800  1.000 23.91880  ? 340 GLY F CA  1 
ATOM   2131 C C   . GLY A 1 305 ? 174.83100 343.06400 27.25300  1.000 25.28093  ? 340 GLY F C   1 
ATOM   2132 O O   . GLY A 1 305 ? 174.38700 343.29800 28.37400  1.000 23.78774  ? 340 GLY F O   1 
ATOM   2133 N N   . TRP A 1 306 ? 175.04400 341.83400 26.77600  1.000 31.14766  ? 341 TRP F N   1 
ATOM   2134 C CA  . TRP A 1 306 ? 174.59900 340.63200 27.46800  1.000 28.53749  ? 341 TRP F CA  1 
ATOM   2135 C C   . TRP A 1 306 ? 175.69000 340.01200 28.33600  1.000 26.53785  ? 341 TRP F C   1 
ATOM   2136 O O   . TRP A 1 306 ? 176.84600 339.88000 27.91600  1.000 25.97192  ? 341 TRP F O   1 
ATOM   2137 C CB  . TRP A 1 306 ? 174.04300 339.59000 26.50600  1.000 25.94601  ? 341 TRP F CB  1 
ATOM   2138 C CG  . TRP A 1 306 ? 172.59800 339.82800 26.08800  1.000 24.53789  ? 341 TRP F CG  1 
ATOM   2139 C CD1 . TRP A 1 306 ? 172.15400 340.31100 24.90600  1.000 28.69332  ? 341 TRP F CD1 1 
ATOM   2140 C CD2 . TRP A 1 306 ? 171.43100 339.67100 26.91800  1.000 24.27580  ? 341 TRP F CD2 1 
ATOM   2141 N NE1 . TRP A 1 306 ? 170.78000 340.39600 24.90800  1.000 28.33476  ? 341 TRP F NE1 1 
ATOM   2142 C CE2 . TRP A 1 306 ? 170.31100 340.01300 26.13300  1.000 26.82317  ? 341 TRP F CE2 1 
ATOM   2143 C CE3 . TRP A 1 306 ? 171.22400 339.24100 28.23800  1.000 27.36346  ? 341 TRP F CE3 1 
ATOM   2144 C CZ2 . TRP A 1 306 ? 168.98700 339.94400 26.62200  1.000 30.43773  ? 341 TRP F CZ2 1 
ATOM   2145 C CZ3 . TRP A 1 306 ? 169.89700 339.16600 28.72900  1.000 29.92673  ? 341 TRP F CZ3 1 
ATOM   2146 C CH2 . TRP A 1 306 ? 168.80000 339.52700 27.91600  1.000 27.31009  ? 341 TRP F CH2 1 
ATOM   2147 N N   . TYR A 1 307 ? 175.31500 339.67300 29.56000  1.000 24.02707  ? 342 TYR F N   1 
ATOM   2148 C CA  . TYR A 1 307 ? 176.13900 338.94800 30.50500  1.000 26.45298  ? 342 TYR F CA  1 
ATOM   2149 C C   . TYR A 1 307 ? 175.50500 337.63200 30.95000  1.000 25.58233  ? 342 TYR F C   1 
ATOM   2150 O O   . TYR A 1 307 ? 174.31500 337.59000 31.29300  1.000 22.66235  ? 342 TYR F O   1 
ATOM   2151 C CB  . TYR A 1 307 ? 176.39700 339.81400 31.74100  1.000 26.95883  ? 342 TYR F CB  1 
ATOM   2152 C CG  . TYR A 1 307 ? 177.18600 341.07000 31.48700  1.000 26.67739  ? 342 TYR F CG  1 
ATOM   2153 C CD1 . TYR A 1 307 ? 176.61800 342.18000 30.91600  1.000 25.75593  ? 342 TYR F CD1 1 
ATOM   2154 C CD2 . TYR A 1 307 ? 178.53400 341.13100 31.82700  1.000 28.34008  ? 342 TYR F CD2 1 
ATOM   2155 C CE1 . TYR A 1 307 ? 177.37400 343.31900 30.69100  1.000 27.24268  ? 342 TYR F CE1 1 
ATOM   2156 C CE2 . TYR A 1 307 ? 179.29100 342.26400 31.60400  1.000 28.14867  ? 342 TYR F CE2 1 
ATOM   2157 C CZ  . TYR A 1 307 ? 178.71300 343.35600 31.03300  1.000 27.51916  ? 342 TYR F CZ  1 
ATOM   2158 O OH  . TYR A 1 307 ? 179.48200 344.48400 30.81500  1.000 29.60072  ? 342 TYR F OH  1 
ATOM   2159 N N   . CYS A 1 308 ? 176.28600 336.55400 30.92700  1.000 23.31885  ? 343 CYS F N   1 
ATOM   2160 C CA  . CYS A 1 308 ? 175.74600 335.28700 31.40800  1.000 23.47235  ? 343 CYS F CA  1 
ATOM   2161 C C   . CYS A 1 308 ? 176.77400 334.61200 32.27700  1.000 24.83724  ? 343 CYS F C   1 
ATOM   2162 O O   . CYS A 1 308 ? 177.94900 334.57200 31.93000  1.000 24.93945  ? 343 CYS F O   1 
ATOM   2163 C CB  . CYS A 1 308 ? 175.33300 334.31600 30.31500  1.000 23.01862  ? 343 CYS F CB  1 
ATOM   2164 S SG  . CYS A 1 308 ? 174.00000 334.87700 29.21700  1.000 39.81126  ? 343 CYS F SG  1 
ATOM   2165 N N   . ASP A 1 309 ? 176.30300 334.03000 33.37800  1.000 25.85524  ? 344 ASP F N   1 
ATOM   2166 C CA  . ASP A 1 309 ? 177.16300 333.21700 34.22600  1.000 24.82754  ? 344 ASP F CA  1 
ATOM   2167 C C   . ASP A 1 309 ? 177.59000 331.97300 33.45500  1.000 27.83427  ? 344 ASP F C   1 
ATOM   2168 O O   . ASP A 1 309 ? 176.76400 331.29900 32.82700  1.000 26.52065  ? 344 ASP F O   1 
ATOM   2169 C CB  . ASP A 1 309 ? 176.44100 332.81500 35.50200  1.000 28.25442  ? 344 ASP F CB  1 
ATOM   2170 C CG  . ASP A 1 309 ? 176.26400 333.96100 36.48500  1.000 32.49867  ? 344 ASP F CG  1 
ATOM   2171 O OD1 . ASP A 1 309 ? 177.16400 334.84000 36.61100  1.000 27.23863  ? 344 ASP F OD1 1 
ATOM   2172 O OD2 . ASP A 1 309 ? 175.21600 333.94400 37.17800  1.000 35.01800  ? 344 ASP F OD2 1 
ATOM   2173 N N   . ASN A 1 310 ? 178.88700 331.69200 33.46900  1.000 23.80305  ? 345 ASN F N   1 
ATOM   2174 C CA  . ASN A 1 310 ? 179.45400 330.59800 32.69200  1.000 22.80198  ? 345 ASN F CA  1 
ATOM   2175 C C   . ASN A 1 310 ? 180.71900 330.08800 33.36500  1.000 26.65036  ? 345 ASN F C   1 
ATOM   2176 O O   . ASN A 1 310 ? 181.70600 330.83100 33.44000  1.000 30.95988  ? 345 ASN F O   1 
ATOM   2177 C CB  . ASN A 1 310 ? 179.70800 331.06700 31.25600  1.000 25.46255  ? 345 ASN F CB  1 
ATOM   2178 C CG  . ASN A 1 310 ? 180.13800 329.94100 30.31300  1.000 27.18117  ? 345 ASN F CG  1 
ATOM   2179 O OD1 . ASN A 1 310 ? 180.12500 328.75200 30.66600  1.000 27.95990  ? 345 ASN F OD1 1 
ATOM   2180 N ND2 . ASN A 1 310 ? 180.44800 330.31600 29.07400  1.000 23.08864  ? 345 ASN F ND2 1 
ATOM   2181 N N   . ALA A 1 311 ? 180.63700 328.90500 33.98700  1.000 23.64754  ? 346 ALA F N   1 
ATOM   2182 C CA  . ALA A 1 311 ? 181.81100 328.17300 34.49100  1.000 20.32404  ? 346 ALA F CA  1 
ATOM   2183 C C   . ALA A 1 311 ? 182.63000 328.99600 35.46300  1.000 20.83149  ? 346 ALA F C   1 
ATOM   2184 O O   . ALA A 1 311 ? 183.85000 329.14000 35.30300  1.000 21.37892  ? 346 ALA F O   1 
ATOM   2185 C CB  . ALA A 1 311 ? 182.70500 327.69300 33.35500  1.000 20.54118  ? 346 ALA F CB  1 
ATOM   2186 N N   . GLY A 1 312 ? 181.95400 329.54100 36.47200  1.000 21.70874  ? 347 GLY F N   1 
ATOM   2187 C CA  . GLY A 1 312 ? 182.60700 330.31400 37.50200  1.000 25.15334  ? 347 GLY F CA  1 
ATOM   2188 C C   . GLY A 1 312 ? 182.97900 331.72200 37.11900  1.000 28.97756  ? 347 GLY F C   1 
ATOM   2189 O O   . GLY A 1 312 ? 183.47900 332.46800 37.97700  1.000 28.96391  ? 347 GLY F O   1 
ATOM   2190 N N   . SER A 1 313 ? 182.79600 332.09600 35.85600  1.000 30.02076  ? 348 SER F N   1 
ATOM   2191 C CA  . SER A 1 313 ? 183.05600 333.42100 35.33700  1.000 22.94887  ? 348 SER F CA  1 
ATOM   2192 C C   . SER A 1 313 ? 181.79400 333.96000 34.68400  1.000 24.18592  ? 348 SER F C   1 
ATOM   2193 O O   . SER A 1 313 ? 180.71100 333.36900 34.78700  1.000 25.42570  ? 348 SER F O   1 
ATOM   2194 C CB  . SER A 1 313 ? 184.19700 333.34900 34.32700  1.000 25.53139  ? 348 SER F CB  1 
ATOM   2195 O OG  . SER A 1 313 ? 185.41400 332.96800 34.94300  1.000 32.75578  ? 348 SER F OG  1 
ATOM   2196 N N   . VAL A 1 314 ? 181.92700 335.12500 34.05600  1.000 23.80382  ? 349 VAL F N   1 
ATOM   2197 C CA  . VAL A 1 314 ? 180.85900 335.75400 33.29300  1.000 24.44647  ? 349 VAL F CA  1 
ATOM   2198 C C   . VAL A 1 314 ? 181.27200 335.84200 31.82200  1.000 24.84049  ? 349 VAL F C   1 
ATOM   2199 O O   . VAL A 1 314 ? 182.38900 336.27600 31.50800  1.000 24.86908  ? 349 VAL F O   1 
ATOM   2200 C CB  . VAL A 1 314 ? 180.48700 337.13700 33.84900  1.000 23.98389  ? 349 VAL F CB  1 
ATOM   2201 C CG1 . VAL A 1 314 ? 179.49100 337.76000 32.93700  1.000 26.80314  ? 349 VAL F CG1 1 
ATOM   2202 C CG2 . VAL A 1 314 ? 179.87100 337.00700 35.21400  1.000 22.54912  ? 349 VAL F CG2 1 
ATOM   2203 N N   . SER A 1 315 ? 180.41300 335.36000 30.93000  1.000 25.19498  ? 350 SER F N   1 
ATOM   2204 C CA  . SER A 1 315 ? 180.62000 335.49400 29.49200  1.000 25.07106  ? 350 SER F CA  1 
ATOM   2205 C C   . SER A 1 315 ? 179.90100 336.76000 29.05000  1.000 27.33753  ? 350 SER F C   1 
ATOM   2206 O O   . SER A 1 315 ? 178.68700 336.89400 29.26600  1.000 28.11453  ? 350 SER F O   1 
ATOM   2207 C CB  . SER A 1 315 ? 180.06900 334.31400 28.71400  1.000 22.62166  ? 350 SER F CB  1 
ATOM   2208 O OG  . SER A 1 315 ? 180.87400 333.18400 28.85500  1.000 26.72140  ? 350 SER F OG  1 
ATOM   2209 N N   . PHE A 1 316 ? 180.67400 337.73100 28.56900  1.000 27.25308  ? 351 PHE F N   1 
ATOM   2210 C CA  . PHE A 1 316 ? 180.16600 339.00400 28.07500  1.000 30.19598  ? 351 PHE F CA  1 
ATOM   2211 C C   . PHE A 1 316 ? 180.09600 339.07400 26.54200  1.000 31.18786  ? 351 PHE F C   1 
ATOM   2212 O O   . PHE A 1 316 ? 181.03200 338.66800 25.85200  1.000 32.47767  ? 351 PHE F O   1 
ATOM   2213 C CB  . PHE A 1 316 ? 181.03800 340.11900 28.63200  1.000 28.64386  ? 351 PHE F CB  1 
ATOM   2214 C CG  . PHE A 1 316 ? 180.75500 341.43100 28.03700  1.000 29.67769  ? 351 PHE F CG  1 
ATOM   2215 C CD1 . PHE A 1 316 ? 179.49400 341.97900 28.12400  1.000 30.17334  ? 351 PHE F CD1 1 
ATOM   2216 C CD2 . PHE A 1 316 ? 181.74900 342.13300 27.39800  1.000 27.05116  ? 351 PHE F CD2 1 
ATOM   2217 C CE1 . PHE A 1 316 ? 179.22700 343.19400 27.55900  1.000 30.69389  ? 351 PHE F CE1 1 
ATOM   2218 C CE2 . PHE A 1 316 ? 181.48500 343.34300 26.84500  1.000 32.04844  ? 351 PHE F CE2 1 
ATOM   2219 C CZ  . PHE A 1 316 ? 180.21300 343.88000 26.91800  1.000 30.91770  ? 351 PHE F CZ  1 
ATOM   2220 N N   . PHE A 1 317 ? 178.98200 339.57800 26.01300  1.000 28.91132  ? 352 PHE F N   1 
ATOM   2221 C CA  . PHE A 1 317 ? 178.77300 339.68600 24.56800  1.000 32.22716  ? 352 PHE F CA  1 
ATOM   2222 C C   . PHE A 1 317 ? 178.62100 341.13500 24.13300  1.000 36.53722  ? 352 PHE F C   1 
ATOM   2223 O O   . PHE A 1 317 ? 177.50500 341.68300 24.20000  1.000 35.29579  ? 352 PHE F O   1 
ATOM   2224 C CB  . PHE A 1 317 ? 177.55800 338.85700 24.15300  1.000 31.98429  ? 352 PHE F CB  1 
ATOM   2225 C CG  . PHE A 1 317 ? 177.62600 337.42800 24.61900  1.000 31.61597  ? 352 PHE F CG  1 
ATOM   2226 C CD1 . PHE A 1 317 ? 177.13400 337.04800 25.86200  1.000 31.04830  ? 352 PHE F CD1 1 
ATOM   2227 C CD2 . PHE A 1 317 ? 178.13900 336.45100 23.78100  1.000 29.84176  ? 352 PHE F CD2 1 
ATOM   2228 C CE1 . PHE A 1 317 ? 177.21200 335.75000 26.27700  1.000 26.33933  ? 352 PHE F CE1 1 
ATOM   2229 C CE2 . PHE A 1 317 ? 178.18100 335.14500 24.17300  1.000 29.25110  ? 352 PHE F CE2 1 
ATOM   2230 C CZ  . PHE A 1 317 ? 177.72700 334.79100 25.42800  1.000 27.16462  ? 352 PHE F CZ  1 
ATOM   2231 N N   . PRO A 1 318 ? 179.67900 341.76100 23.59500  1.000 37.05981  ? 353 PRO F N   1 
ATOM   2232 C CA  . PRO A 1 318 ? 179.58600 343.19300 23.22900  1.000 37.54590  ? 353 PRO F CA  1 
ATOM   2233 C C   . PRO A 1 318 ? 178.77700 343.49700 21.96100  1.000 44.13285  ? 353 PRO F C   1 
ATOM   2234 O O   . PRO A 1 318 ? 178.08300 344.51500 21.97100  1.000 48.21464  ? 353 PRO F O   1 
ATOM   2235 C CB  . PRO A 1 318 ? 181.05500 343.61600 23.12500  1.000 34.70966  ? 353 PRO F CB  1 
ATOM   2236 C CG  . PRO A 1 318 ? 181.78300 342.36800 22.79100  1.000 34.69800  ? 353 PRO F CG  1 
ATOM   2237 C CD  . PRO A 1 318 ? 181.05300 341.24600 23.49100  1.000 34.89737  ? 353 PRO F CD  1 
ATOM   2238 N N   . GLN A 1 319 ? 178.85400 342.70100 20.87500  1.000 43.36137  ? 354 GLN F N   1 
ATOM   2239 C CA  . GLN A 1 319 ? 178.05300 342.95700 19.66100  1.000 49.15144  ? 354 GLN F CA  1 
ATOM   2240 C C   . GLN A 1 319 ? 176.57100 342.66400 19.89100  1.000 59.41571  ? 354 GLN F C   1 
ATOM   2241 O O   . GLN A 1 319 ? 176.20500 341.69500 20.57200  1.000 60.21065  ? 354 GLN F O   1 
ATOM   2242 C CB  . GLN A 1 319 ? 178.49100 342.13500 18.42800  1.000 54.01508  ? 354 GLN F CB  1 
ATOM   2243 C CG  . GLN A 1 319 ? 179.64700 342.62300 17.54100  1.000 57.23086  ? 354 GLN F CG  1 
ATOM   2244 C CD  . GLN A 1 319 ? 181.00600 342.59700 18.18300  1.000 68.02045  ? 354 GLN F CD  1 
ATOM   2245 O OE1 . GLN A 1 319 ? 181.70700 343.61300 18.20900  1.000 68.28281  ? 354 GLN F OE1 1 
ATOM   2246 N NE2 . GLN A 1 319 ? 181.41500 341.42600 18.66800  1.000 68.20705  ? 354 GLN F NE2 1 
ATOM   2247 N N   . ALA A 1 320 ? 175.70600 343.48300 19.27100  1.000 63.39806  ? 355 ALA F N   1 
ATOM   2248 C CA  . ALA A 1 320 ? 174.27200 343.39500 19.54500  1.000 62.77257  ? 355 ALA F CA  1 
ATOM   2249 C C   . ALA A 1 320 ? 173.61100 342.23800 18.81000  1.000 62.66459  ? 355 ALA F C   1 
ATOM   2250 O O   . ALA A 1 320 ? 172.66700 341.62600 19.33300  1.000 65.21424  ? 355 ALA F O   1 
ATOM   2251 C CB  . ALA A 1 320 ? 173.59000 344.71400 19.17800  1.000 63.71315  ? 355 ALA F CB  1 
ATOM   2252 N N   . GLU A 1 321 ? 174.13400 341.87800 17.65100  1.000 60.56799  ? 356 GLU F N   1 
ATOM   2253 C CA  . GLU A 1 321 ? 173.54400 340.84100 16.82000  1.000 70.48273  ? 356 GLU F CA  1 
ATOM   2254 C C   . GLU A 1 321 ? 174.03000 339.43800 17.17000  1.000 63.15241  ? 356 GLU F C   1 
ATOM   2255 O O   . GLU A 1 321 ? 173.48600 338.45700 16.65000  1.000 67.24697  ? 356 GLU F O   1 
ATOM   2256 C CB  . GLU A 1 321 ? 173.90000 341.15000 15.34800  1.000 79.78393  ? 356 GLU F CB  1 
ATOM   2257 C CG  . GLU A 1 321 ? 175.41700 340.92000 15.03900  1.000 84.28375  ? 356 GLU F CG  1 
ATOM   2258 C CD  . GLU A 1 321 ? 175.77500 340.73700 13.55900  1.000 93.48393  ? 356 GLU F CD  1 
ATOM   2259 O OE1 . GLU A 1 321 ? 174.85600 340.71700 12.70600  1.000 96.28817  ? 356 GLU F OE1 1 
ATOM   2260 O OE2 . GLU A 1 321 ? 176.99300 340.61900 13.25800  1.000 93.51740  ? 356 GLU F OE2 1 
ATOM   2261 N N   . THR A 1 322 ? 174.91500 339.30900 18.14300  1.000 56.27483  ? 357 THR F N   1 
ATOM   2262 C CA  . THR A 1 322 ? 175.44300 338.01000 18.52000  1.000 59.04495  ? 357 THR F CA  1 
ATOM   2263 C C   . THR A 1 322 ? 174.56000 337.23900 19.48600  1.000 56.49298  ? 357 THR F C   1 
ATOM   2264 O O   . THR A 1 322 ? 174.88300 336.08900 19.80200  1.000 55.88562  ? 357 THR F O   1 
ATOM   2265 C CB  . THR A 1 322 ? 176.86200 338.19300 19.09100  1.000 57.98610  ? 357 THR F CB  1 
ATOM   2266 O OG1 . THR A 1 322 ? 176.82900 339.11800 20.19100  1.000 55.40948  ? 357 THR F OG1 1 
ATOM   2267 C CG2 . THR A 1 322 ? 177.82000 338.72300 18.01000  1.000 59.61844  ? 357 THR F CG2 1 
ATOM   2268 N N   . CYS A 1 323 ? 173.42400 337.78700 19.90000  1.000 50.05061  ? 358 CYS F N   1 
ATOM   2269 C CA  . CYS A 1 323 ? 172.54700 337.08000 20.82300  1.000 45.17042  ? 358 CYS F CA  1 
ATOM   2270 C C   . CYS A 1 323 ? 171.10200 337.19500 20.36900  1.000 45.31804  ? 358 CYS F C   1 
ATOM   2271 O O   . CYS A 1 323 ? 170.57500 338.30000 20.25300  1.000 49.40913  ? 358 CYS F O   1 
ATOM   2272 C CB  . CYS A 1 323 ? 172.68200 337.63300 22.25500  1.000 42.51476  ? 358 CYS F CB  1 
ATOM   2273 S SG  . CYS A 1 323 ? 174.21800 337.27400 23.17500  1.000 40.75427  ? 358 CYS F SG  1 
ATOM   2274 N N   . LYS A 1 324 ? 170.48100 336.06200 20.06800  1.000 41.45593  ? 359 LYS F N   1 
ATOM   2275 C CA  . LYS A 1 324 ? 169.06700 336.01300 19.71900  1.000 40.36489  ? 359 LYS F CA  1 
ATOM   2276 C C   . LYS A 1 324 ? 168.27400 335.66600 20.98300  1.000 42.75418  ? 359 LYS F C   1 
ATOM   2277 O O   . LYS A 1 324 ? 168.63200 334.73900 21.71500  1.000 39.41441  ? 359 LYS F O   1 
ATOM   2278 C CB  . LYS A 1 324 ? 168.84300 334.96100 18.62500  1.000 38.02559  ? 359 LYS F CB  1 
ATOM   2279 C CG  . LYS A 1 324 ? 169.00100 335.47000 17.17800  1.000 43.56334  ? 359 LYS F CG  1 
ATOM   2280 C CD  . LYS A 1 324 ? 170.45600 335.85600 16.86100  1.000 48.05521  ? 359 LYS F CD  1 
ATOM   2281 C CE  . LYS A 1 324 ? 171.31800 334.68500 16.36800  1.000 54.70436  ? 359 LYS F CE  1 
ATOM   2282 N NZ  . LYS A 1 324 ? 172.80400 334.80500 16.70700  1.000 54.16500  ? 359 LYS F NZ  1 
ATOM   2283 N N   . VAL A 1 325 ? 167.17700 336.36500 21.23800  1.000 48.63929  ? 360 VAL F N   1 
ATOM   2284 C CA  . VAL A 1 325 ? 166.42000 336.13700 22.46700  1.000 43.70184  ? 360 VAL F CA  1 
ATOM   2285 C C   . VAL A 1 325 ? 165.06100 335.56000 22.10500  1.000 48.15336  ? 360 VAL F C   1 
ATOM   2286 O O   . VAL A 1 325 ? 164.40000 336.04500 21.18300  1.000 59.74900  ? 360 VAL F O   1 
ATOM   2287 C CB  . VAL A 1 325 ? 166.29400 337.42400 23.29400  1.000 44.28037  ? 360 VAL F CB  1 
ATOM   2288 C CG1 . VAL A 1 325 ? 165.57300 337.14600 24.58400  1.000 40.49030  ? 360 VAL F CG1 1 
ATOM   2289 C CG2 . VAL A 1 325 ? 167.67600 337.95900 23.60100  1.000 40.89224  ? 360 VAL F CG2 1 
ATOM   2290 N N   . GLN A 1 326 ? 164.66000 334.51300 22.82800  1.000 43.74963  ? 361 GLN F N   1 
ATOM   2291 C CA  . GLN A 1 326 ? 163.33500 333.89200 22.76400  1.000 47.21099  ? 361 GLN F CA  1 
ATOM   2292 C C   . GLN A 1 326 ? 162.73700 333.78100 24.16200  1.000 49.96420  ? 361 GLN F C   1 
ATOM   2293 O O   . GLN A 1 326 ? 163.21400 332.99400 24.98600  1.000 52.18712  ? 361 GLN F O   1 
ATOM   2294 C CB  . GLN A 1 326 ? 163.43400 332.50000 22.12700  1.000 51.24432  ? 361 GLN F CB  1 
ATOM   2295 C CG  . GLN A 1 326 ? 162.24600 332.04100 21.29500  1.000 63.52746  ? 361 GLN F CG  1 
ATOM   2296 C CD  . GLN A 1 326 ? 161.79300 333.08800 20.31900  1.000 81.00118  ? 361 GLN F CD  1 
ATOM   2297 O OE1 . GLN A 1 326 ? 162.26100 333.15100 19.17000  1.000 79.07220  ? 361 GLN F OE1 1 
ATOM   2298 N NE2 . GLN A 1 326 ? 160.89300 333.96400 20.79100  1.000 81.71268  ? 361 GLN F NE2 1 
ATOM   2299 N N   . SER A 1 327 ? 161.65900 334.51500 24.41500  1.000 53.59962  ? 362 SER F N   1 
ATOM   2300 C CA  . SER A 1 327 ? 161.00500 334.41200 25.71300  1.000 55.02976  ? 362 SER F CA  1 
ATOM   2301 C C   . SER A 1 327 ? 161.90400 334.99800 26.79700  1.000 55.35756  ? 362 SER F C   1 
ATOM   2302 O O   . SER A 1 327 ? 162.14800 336.21300 26.84600  1.000 54.07495  ? 362 SER F O   1 
ATOM   2303 C CB  . SER A 1 327 ? 160.68800 332.94400 26.04100  1.000 48.79577  ? 362 SER F CB  1 
ATOM   2304 O OG  . SER A 1 327 ? 159.97300 332.31200 24.98400  1.000 55.81185  ? 362 SER F OG  1 
ATOM   2305 N N   . ASN A 1 328 ? 162.39400 334.13000 27.67500  1.000 48.33590  ? 363 ASN F N   1 
ATOM   2306 C CA  . ASN A 1 328 ? 163.36900 334.50300 28.68000  1.000 42.00428  ? 363 ASN F CA  1 
ATOM   2307 C C   . ASN A 1 328 ? 164.74100 333.90000 28.39900  1.000 39.25763  ? 363 ASN F C   1 
ATOM   2308 O O   . ASN A 1 328 ? 165.62500 333.99400 29.25700  1.000 35.79541  ? 363 ASN F O   1 
ATOM   2309 C CB  . ASN A 1 328 ? 162.88800 334.02700 30.05100  1.000 41.38438  ? 363 ASN F CB  1 
ATOM   2310 C CG  . ASN A 1 328 ? 162.26500 332.63700 29.97600  1.000 57.68713  ? 363 ASN F CG  1 
ATOM   2311 O OD1 . ASN A 1 328 ? 162.33800 331.96800 28.93400  1.000 56.92994  ? 363 ASN F OD1 1 
ATOM   2312 N ND2 . ASN A 1 328 ? 161.73500 332.15700 31.09100  1.000 65.79097  ? 363 ASN F ND2 1 
ATOM   2313 N N   . ARG A 1 329 ? 164.93500 333.23700 27.25700  1.000 36.03704  ? 364 ARG F N   1 
ATOM   2314 C CA  . ARG A 1 329 ? 166.19000 332.54800 26.97900  1.000 37.77243  ? 364 ARG F CA  1 
ATOM   2315 C C   . ARG A 1 329 ? 167.04000 333.28700 25.95100  1.000 34.04269  ? 364 ARG F C   1 
ATOM   2316 O O   . ARG A 1 329 ? 166.55400 333.65200 24.88000  1.000 35.72839  ? 364 ARG F O   1 
ATOM   2317 C CB  . ARG A 1 329 ? 165.94700 331.12300 26.49500  1.000 39.64581  ? 364 ARG F CB  1 
ATOM   2318 C CG  . ARG A 1 329 ? 167.22700 330.31100 26.52300  1.000 33.86854  ? 364 ARG F CG  1 
ATOM   2319 C CD  . ARG A 1 329 ? 166.92600 328.86200 26.37700  1.000 37.49077  ? 364 ARG F CD  1 
ATOM   2320 N NE  . ARG A 1 329 ? 166.04200 328.39500 27.43700  1.000 41.42990  ? 364 ARG F NE  1 
ATOM   2321 C CZ  . ARG A 1 329 ? 166.47700 327.93000 28.60000  1.000 43.22093  ? 364 ARG F CZ  1 
ATOM   2322 N NH1 . ARG A 1 329 ? 167.76400 327.94600 28.90600  1.000 41.50714  ? 364 ARG F NH1 1 
ATOM   2323 N NH2 . ARG A 1 329 ? 165.60400 327.41700 29.46600  1.000 40.15695  ? 364 ARG F NH2 1 
ATOM   2324 N N   . VAL A 1 330 ? 168.32700 333.46000 26.26600  1.000 33.62576  ? 365 VAL F N   1 
ATOM   2325 C CA  . VAL A 1 330 ? 169.29200 334.08600 25.36900  1.000 32.92870  ? 365 VAL F CA  1 
ATOM   2326 C C   . VAL A 1 330 ? 170.09000 332.99500 24.66900  1.000 32.24769  ? 365 VAL F C   1 
ATOM   2327 O O   . VAL A 1 330 ? 170.68800 332.14700 25.32400  1.000 33.38938  ? 365 VAL F O   1 
ATOM   2328 C CB  . VAL A 1 330 ? 170.20400 335.01000 26.20300  1.000 31.71306  ? 365 VAL F CB  1 
ATOM   2329 C CG1 . VAL A 1 330 ? 170.94000 335.98800 25.34700  1.000 31.76783  ? 365 VAL F CG1 1 
ATOM   2330 C CG2 . VAL A 1 330 ? 169.34900 335.75700 27.20900  1.000 32.21639  ? 365 VAL F CG2 1 
ATOM   2331 N N   . PHE A 1 331 ? 170.29400 333.13700 23.37300  1.000 35.05828  ? 366 PHE F N   1 
ATOM   2332 C CA  . PHE A 1 331 ? 171.04500 332.15800 22.59600  1.000 32.42347  ? 366 PHE F CA  1 
ATOM   2333 C C   . PHE A 1 331 ? 172.20800 332.93600 22.00500  1.000 34.88028  ? 366 PHE F C   1 
ATOM   2334 O O   . PHE A 1 331 ? 172.01800 333.79200 21.13100  1.000 37.04025  ? 366 PHE F O   1 
ATOM   2335 C CB  . PHE A 1 331 ? 170.22000 331.54800 21.47200  1.000 30.19767  ? 366 PHE F CB  1 
ATOM   2336 C CG  . PHE A 1 331 ? 169.11200 330.66600 21.89700  1.000 27.40656  ? 366 PHE F CG  1 
ATOM   2337 C CD1 . PHE A 1 331 ? 167.89600 331.19600 22.28000  1.000 31.15132  ? 366 PHE F CD1 1 
ATOM   2338 C CD2 . PHE A 1 331 ? 169.23500 329.28800 21.79500  1.000 29.44621  ? 366 PHE F CD2 1 
ATOM   2339 C CE1 . PHE A 1 331 ? 166.82400 330.36800 22.62800  1.000 31.59712  ? 366 PHE F CE1 1 
ATOM   2340 C CE2 . PHE A 1 331 ? 168.17700 328.44800 22.14200  1.000 30.74376  ? 366 PHE F CE2 1 
ATOM   2341 C CZ  . PHE A 1 331 ? 166.97200 328.98800 22.56300  1.000 32.51292  ? 366 PHE F CZ  1 
ATOM   2342 N N   . CYS A 1 332 ? 173.36800 332.72200 22.58800  1.000 31.51381  ? 367 CYS F N   1 
ATOM   2343 C CA  . CYS A 1 332 ? 174.61300 333.37400 22.24400  1.000 32.40358  ? 367 CYS F CA  1 
ATOM   2344 C C   . CYS A 1 332 ? 175.60000 332.33800 21.70600  1.000 32.54711  ? 367 CYS F C   1 
ATOM   2345 O O   . CYS A 1 332 ? 175.45100 331.13800 21.92300  1.000 30.78460  ? 367 CYS F O   1 
ATOM   2346 C CB  . CYS A 1 332 ? 175.15500 334.13900 23.45200  1.000 29.32706  ? 367 CYS F CB  1 
ATOM   2347 S SG  . CYS A 1 332 ? 173.93600 335.40400 24.02300  1.000 39.88573  ? 367 CYS F SG  1 
ATOM   2348 N N   . ASP A 1 333 ? 176.64500 332.81400 21.04300  1.000 37.55038  ? 368 ASP F N   1 
ATOM   2349 C CA  . ASP A 1 333 ? 177.72900 331.97400 20.54000  1.000 37.34594  ? 368 ASP F CA  1 
ATOM   2350 C C   . ASP A 1 333 ? 178.94000 332.38400 21.36200  1.000 33.69664  ? 368 ASP F C   1 
ATOM   2351 O O   . ASP A 1 333 ? 179.32800 333.55100 21.35400  1.000 35.68026  ? 368 ASP F O   1 
ATOM   2352 C CB  . ASP A 1 333 ? 178.00600 332.20200 19.04600  1.000 33.42800  ? 368 ASP F CB  1 
ATOM   2353 C CG  . ASP A 1 333 ? 178.89100 331.10600 18.42700  1.000 34.19987  ? 368 ASP F CG  1 
ATOM   2354 O OD1 . ASP A 1 333 ? 179.84300 330.67200 19.09000  1.000 36.63559  ? 368 ASP F OD1 1 
ATOM   2355 O OD2 . ASP A 1 333 ? 178.65300 330.64300 17.30900  1.000 32.22891  ? 368 ASP F OD2 1 
ATOM   2356 N N   . THR A 1 334 ? 179.56000 331.41900 22.05200  1.000 30.98610  ? 369 THR F N   1 
ATOM   2357 C CA  . THR A 1 334 ? 180.67800 331.87400 22.86300  1.000 33.85601  ? 369 THR F CA  1 
ATOM   2358 C C   . THR A 1 334 ? 181.84800 332.27800 21.99400  1.000 36.30482  ? 369 THR F C   1 
ATOM   2359 O O   . THR A 1 334 ? 182.82900 332.81900 22.50400  1.000 35.85558  ? 369 THR F O   1 
ATOM   2360 C CB  . THR A 1 334 ? 181.10500 330.81700 23.88400  1.000 29.90952  ? 369 THR F CB  1 
ATOM   2361 O OG1 . THR A 1 334 ? 181.57200 329.64100 23.21300  1.000 34.96704  ? 369 THR F OG1 1 
ATOM   2362 C CG2 . THR A 1 334 ? 179.95800 330.45100 24.75400  1.000 27.22463  ? 369 THR F CG2 1 
ATOM   2363 N N   . MET A 1 335 ? 181.74400 332.04200 20.69100  1.000 36.68844  ? 370 MET F N   1 
ATOM   2364 C CA  . MET A 1 335 ? 182.79300 332.43900 19.76900  1.000 37.17365  ? 370 MET F CA  1 
ATOM   2365 C C   . MET A 1 335 ? 182.96800 333.96000 19.84200  1.000 39.10760  ? 370 MET F C   1 
ATOM   2366 O O   . MET A 1 335 ? 184.07500 334.47100 19.65300  1.000 43.54694  ? 370 MET F O   1 
ATOM   2367 C CB  . MET A 1 335 ? 182.48600 331.92000 18.36900  1.000 46.80403  ? 370 MET F CB  1 
ATOM   2368 C CG  . MET A 1 335 ? 183.47100 332.30000 17.27300  1.000 57.46544  ? 370 MET F CG  1 
ATOM   2369 S SD  . MET A 1 335 ? 184.83700 331.07300 17.36300  1.000 65.42772  ? 370 MET F SD  1 
ATOM   2370 C CE  . MET A 1 335 ? 183.99900 329.60400 16.74000  1.000 49.01844  ? 370 MET F CE  1 
ATOM   2371 N N   . ASN A 1 336 ? 181.86800 334.71400 20.04500  1.000 39.13641  ? 371 ASN F N   1 
ATOM   2372 C CA  . ASN A 1 336 ? 182.03500 336.16100 20.10900  1.000 44.09079  ? 371 ASN F CA  1 
ATOM   2373 C C   . ASN A 1 336 ? 181.67800 336.69000 21.49400  1.000 44.33387  ? 371 ASN F C   1 
ATOM   2374 O O   . ASN A 1 336 ? 180.77700 337.52900 21.65300  1.000 45.05539  ? 371 ASN F O   1 
ATOM   2375 C CB  . ASN A 1 336 ? 181.11300 336.90900 19.13400  1.000 50.68690  ? 371 ASN F CB  1 
ATOM   2376 C CG  . ASN A 1 336 ? 180.88400 336.18000 17.84500  1.000 50.47771  ? 371 ASN F CG  1 
ATOM   2377 O OD1 . ASN A 1 336 ? 179.89500 335.45500 17.70300  1.000 46.29197  ? 371 ASN F OD1 1 
ATOM   2378 N ND2 . ASN A 1 336 ? 181.78900 336.36700 16.88800  1.000 52.50898  ? 371 ASN F ND2 1 
ATOM   2379 N N   . SER A 1 337 ? 182.46700 336.27700 22.48500  1.000 39.68469  ? 372 SER F N   1 
ATOM   2380 C CA  . SER A 1 337 ? 182.28300 336.66100 23.87300  1.000 34.49689  ? 372 SER F CA  1 
ATOM   2381 C C   . SER A 1 337 ? 183.66400 336.99400 24.40400  1.000 32.40953  ? 372 SER F C   1 
ATOM   2382 O O   . SER A 1 337 ? 184.68400 336.57100 23.84600  1.000 31.54099  ? 372 SER F O   1 
ATOM   2383 C CB  . SER A 1 337 ? 181.62300 335.57900 24.75100  1.000 31.98397  ? 372 SER F CB  1 
ATOM   2384 O OG  . SER A 1 337 ? 182.39700 334.39500 24.83600  1.000 30.35765  ? 372 SER F OG  1 
ATOM   2385 N N   . LEU A 1 338 ? 183.68200 337.76500 25.47700  1.000 28.70435  ? 373 LEU F N   1 
ATOM   2386 C CA  . LEU A 1 338 ? 184.84000 337.91600 26.32800  1.000 26.60131  ? 373 LEU F CA  1 
ATOM   2387 C C   . LEU A 1 338 ? 184.53400 337.23800 27.65500  1.000 27.70634  ? 373 LEU F C   1 
ATOM   2388 O O   . LEU A 1 338 ? 183.38200 337.14400 28.08500  1.000 27.19043  ? 373 LEU F O   1 
ATOM   2389 C CB  . LEU A 1 338 ? 185.17400 339.39100 26.53600  1.000 31.21339  ? 373 LEU F CB  1 
ATOM   2390 C CG  . LEU A 1 338 ? 185.42300 340.20400 25.26100  1.000 28.35083  ? 373 LEU F CG  1 
ATOM   2391 C CD1 . LEU A 1 338 ? 185.69000 341.66300 25.58800  1.000 21.47353  ? 373 LEU F CD1 1 
ATOM   2392 C CD2 . LEU A 1 338 ? 186.57400 339.61100 24.45000  1.000 23.87398  ? 373 LEU F CD2 1 
ATOM   2393 N N   . THR A 1 339 ? 185.56200 336.75600 28.30000  1.000 26.82095  ? 374 THR F N   1 
ATOM   2394 C CA  . THR A 1 339 ? 185.40600 336.09200 29.57800  1.000 25.99066  ? 374 THR F CA  1 
ATOM   2395 C C   . THR A 1 339 ? 185.88200 337.06400 30.65000  1.000 26.96818  ? 374 THR F C   1 
ATOM   2396 O O   . THR A 1 339 ? 187.01100 337.56300 30.58100  1.000 25.55974  ? 374 THR F O   1 
ATOM   2397 C CB  . THR A 1 339 ? 186.13900 334.76300 29.57200  1.000 26.17240  ? 374 THR F CB  1 
ATOM   2398 O OG1 . THR A 1 339 ? 185.62900 334.01300 28.46300  1.000 28.14863  ? 374 THR F OG1 1 
ATOM   2399 C CG2 . THR A 1 339 ? 185.81500 333.98500 30.82200  1.000 23.70416  ? 374 THR F CG2 1 
ATOM   2400 N N   . LEU A 1 340 ? 184.98400 337.42100 31.56600  1.000 25.42803  ? 375 LEU F N   1 
ATOM   2401 C CA  . LEU A 1 340 ? 185.26600 338.37000 32.63000  1.000 29.77492  ? 375 LEU F CA  1 
ATOM   2402 C C   . LEU A 1 340 ? 185.07600 337.74100 33.99900  1.000 28.79243  ? 375 LEU F C   1 
ATOM   2403 O O   . LEU A 1 340 ? 184.33800 336.76000 34.15100  1.000 27.18322  ? 375 LEU F O   1 
ATOM   2404 C CB  . LEU A 1 340 ? 184.34100 339.59100 32.55200  1.000 29.55321  ? 375 LEU F CB  1 
ATOM   2405 C CG  . LEU A 1 340 ? 184.35000 340.31600 31.21900  1.000 29.21383  ? 375 LEU F CG  1 
ATOM   2406 C CD1 . LEU A 1 340 ? 183.36600 341.46500 31.23700  1.000 26.56163  ? 375 LEU F CD1 1 
ATOM   2407 C CD2 . LEU A 1 340 ? 185.77100 340.76600 30.88400  1.000 27.15978  ? 375 LEU F CD2 1 
ATOM   2408 N N   . PRO A 1 341 ? 185.78300 338.25100 35.00300  1.000 28.60727  ? 376 PRO F N   1 
ATOM   2409 C CA  . PRO A 1 341 ? 185.54900 337.78300 36.37500  1.000 32.74223  ? 376 PRO F CA  1 
ATOM   2410 C C   . PRO A 1 341 ? 184.14900 338.11500 36.86400  1.000 31.53936  ? 376 PRO F C   1 
ATOM   2411 O O   . PRO A 1 341 ? 183.58700 339.14900 36.52000  1.000 39.89939  ? 376 PRO F O   1 
ATOM   2412 C CB  . PRO A 1 341 ? 186.60600 338.52900 37.18500  1.000 28.98198  ? 376 PRO F CB  1 
ATOM   2413 C CG  . PRO A 1 341 ? 186.93400 339.69200 36.36100  1.000 29.75556  ? 376 PRO F CG  1 
ATOM   2414 C CD  . PRO A 1 341 ? 186.83000 339.26400 34.93500  1.000 26.74899  ? 376 PRO F CD  1 
ATOM   2415 N N   . SER A 1 342 ? 183.61800 337.26400 37.74600  1.000 29.15314  ? 377 SER F N   1 
ATOM   2416 C CA  . SER A 1 342 ? 182.26400 337.47600 38.24200  1.000 32.14074  ? 377 SER F CA  1 
ATOM   2417 C C   . SER A 1 342 ? 182.13800 338.76900 39.02700  1.000 32.99526  ? 377 SER F C   1 
ATOM   2418 O O   . SER A 1 342 ? 181.03500 339.33800 39.08100  1.000 33.85677  ? 377 SER F O   1 
ATOM   2419 C CB  . SER A 1 342 ? 181.80200 336.28200 39.10800  1.000 36.66787  ? 377 SER F CB  1 
ATOM   2420 O OG  . SER A 1 342 ? 182.63800 336.07900 40.24300  1.000 42.23005  ? 377 SER F OG  1 
ATOM   2421 N N   . GLU A 1 343 ? 183.26000 339.36500 39.42600  1.000 36.27613  ? 378 GLU F N   1 
ATOM   2422 C CA  . GLU A 1 343 ? 183.17400 340.63400 40.13800  1.000 36.32123  ? 378 GLU F CA  1 
ATOM   2423 C C   . GLU A 1 343 ? 182.74300 341.77200 39.22000  1.000 37.30380  ? 378 GLU F C   1 
ATOM   2424 O O   . GLU A 1 343 ? 182.53100 342.87600 39.71200  1.000 38.08501  ? 378 GLU F O   1 
ATOM   2425 C CB  . GLU A 1 343 ? 184.49900 341.02900 40.79700  1.000 38.35181  ? 378 GLU F CB  1 
ATOM   2426 C CG  . GLU A 1 343 ? 184.95600 340.27200 42.03800  1.000 48.36247  ? 378 GLU F CG  1 
ATOM   2427 C CD  . GLU A 1 343 ? 185.32700 338.82400 41.82100  1.000 45.61214  ? 378 GLU F CD  1 
ATOM   2428 O OE1 . GLU A 1 343 ? 185.90900 338.49400 40.75400  1.000 37.11104  ? 378 GLU F OE1 1 
ATOM   2429 O OE2 . GLU A 1 343 ? 185.05800 338.03400 42.76300  1.000 48.21888  ? 378 GLU F OE2 1 
ATOM   2430 N N   . VAL A 1 344 ? 182.62300 341.54200 37.90700  1.000 35.07136  ? 379 VAL F N   1 
ATOM   2431 C CA  . VAL A 1 344 ? 182.19500 342.61100 37.02300  1.000 35.56841  ? 379 VAL F CA  1 
ATOM   2432 C C   . VAL A 1 344 ? 180.74900 342.97900 37.36100  1.000 34.64624  ? 379 VAL F C   1 
ATOM   2433 O O   . VAL A 1 344 ? 180.32900 344.13100 37.15800  1.000 36.17967  ? 379 VAL F O   1 
ATOM   2434 C CB  . VAL A 1 344 ? 182.32400 342.19900 35.54100  1.000 33.33205  ? 379 VAL F CB  1 
ATOM   2435 C CG1 . VAL A 1 344 ? 181.23500 341.18600 35.16800  1.000 30.16580  ? 379 VAL F CG1 1 
ATOM   2436 C CG2 . VAL A 1 344 ? 182.25500 343.42300 34.62800  1.000 32.62148  ? 379 VAL F CG2 1 
ATOM   2437 N N   . ASN A 1 345 ? 180.01100 342.07000 37.99600  1.000 30.01252  ? 380 ASN F N   1 
ATOM   2438 C CA  . ASN A 1 345 ? 178.65700 342.47000 38.33900  1.000 31.98745  ? 380 ASN F CA  1 
ATOM   2439 C C   . ASN A 1 345 ? 178.68100 343.50000 39.46000  1.000 37.43152  ? 380 ASN F C   1 
ATOM   2440 O O   . ASN A 1 345 ? 177.70400 344.24100 39.65000  1.000 40.26062  ? 380 ASN F O   1 
ATOM   2441 C CB  . ASN A 1 345 ? 177.74600 341.28500 38.71500  1.000 34.79671  ? 380 ASN F CB  1 
ATOM   2442 C CG  . ASN A 1 345 ? 176.24300 341.70700 38.91900  1.000 42.00519  ? 380 ASN F CG  1 
ATOM   2443 O OD1 . ASN A 1 345 ? 175.92700 342.80500 39.35900  1.000 45.20602  ? 380 ASN F OD1 1 
ATOM   2444 N ND2 . ASN A 1 345 ? 175.32600 340.84000 38.49900  1.000 45.75423  ? 380 ASN F ND2 1 
ATOM   2445 N N   . LEU A 1 346 ? 179.80200 343.67300 40.12500  1.000 33.95245  ? 381 LEU F N   1 
ATOM   2446 C CA  . LEU A 1 346 ? 179.71200 344.63700 41.19600  1.000 34.83454  ? 381 LEU F CA  1 
ATOM   2447 C C   . LEU A 1 346 ? 179.70400 346.06300 40.67800  1.000 36.52909  ? 381 LEU F C   1 
ATOM   2448 O O   . LEU A 1 346 ? 179.29000 346.95600 41.43500  1.000 38.53285  ? 381 LEU F O   1 
ATOM   2449 C CB  . LEU A 1 346 ? 180.96100 344.44300 42.06500  1.000 35.37830  ? 381 LEU F CB  1 
ATOM   2450 C CG  . LEU A 1 346 ? 180.99600 343.40400 43.19100  1.000 29.88802  ? 381 LEU F CG  1 
ATOM   2451 C CD1 . LEU A 1 346 ? 182.33200 343.50500 43.90800  1.000 30.85306  ? 381 LEU F CD1 1 
ATOM   2452 C CD2 . LEU A 1 346 ? 179.78000 343.38200 44.11700  1.000 21.61930  ? 381 LEU F CD2 1 
ATOM   2453 N N   . CYS A 1 347 ? 179.87400 346.25800 39.35600  1.000 37.51376  ? 382 CYS F N   1 
ATOM   2454 C CA  . CYS A 1 347 ? 179.73700 347.60700 38.81900  1.000 34.15462  ? 382 CYS F CA  1 
ATOM   2455 C C   . CYS A 1 347 ? 178.28900 348.04700 38.84100  1.000 37.23315  ? 382 CYS F C   1 
ATOM   2456 O O   . CYS A 1 347 ? 178.01200 349.23800 38.69000  1.000 40.73036  ? 382 CYS F O   1 
ATOM   2457 C CB  . CYS A 1 347 ? 180.25700 347.66300 37.40000  1.000 33.17891  ? 382 CYS F CB  1 
ATOM   2458 S SG  . CYS A 1 347 ? 182.00000 347.40400 37.34300  1.000 49.88894  ? 382 CYS F SG  1 
ATOM   2459 N N   . ASN A 1 348 ? 177.36900 347.08300 38.91400  1.000 35.65513  ? 383 ASN F N   1 
ATOM   2460 C CA  . ASN A 1 348 ? 175.94500 347.32900 39.00500  1.000 35.16600  ? 383 ASN F CA  1 
ATOM   2461 C C   . ASN A 1 348 ? 175.50300 347.67300 40.41900  1.000 39.75597  ? 383 ASN F C   1 
ATOM   2462 O O   . ASN A 1 348 ? 174.36500 348.12400 40.59200  1.000 38.72339  ? 383 ASN F O   1 
ATOM   2463 C CB  . ASN A 1 348 ? 175.13900 346.20300 38.39700  1.000 32.24207  ? 383 ASN F CB  1 
ATOM   2464 C CG  . ASN A 1 348 ? 175.63800 345.85800 37.03500  1.000 33.90367  ? 383 ASN F CG  1 
ATOM   2465 O OD1 . ASN A 1 348 ? 175.51500 346.65400 36.11000  1.000 32.65612  ? 383 ASN F OD1 1 
ATOM   2466 N ND2 . ASN A 1 348 ? 176.10300 344.62700 36.86500  1.000 39.83891  ? 383 ASN F ND2 1 
ATOM   2467 N N   . VAL A 1 349 ? 176.24200 347.28500 41.45800  1.000 40.33732  ? 384 VAL F N   1 
ATOM   2468 C CA  . VAL A 1 349 ? 175.79600 347.64500 42.79700  1.000 46.00211  ? 384 VAL F CA  1 
ATOM   2469 C C   . VAL A 1 349 ? 176.63500 348.75700 43.45400  1.000 47.14214  ? 384 VAL F C   1 
ATOM   2470 O O   . VAL A 1 349 ? 176.09700 349.51800 44.27800  1.000 39.82984  ? 384 VAL F O   1 
ATOM   2471 C CB  . VAL A 1 349 ? 175.75300 346.38500 43.68300  1.000 39.46463  ? 384 VAL F CB  1 
ATOM   2472 C CG1 . VAL A 1 349 ? 177.11800 345.79400 43.78200  1.000 36.00103  ? 384 VAL F CG1 1 
ATOM   2473 C CG2 . VAL A 1 349 ? 175.22300 346.73800 45.06200  1.000 45.60723  ? 384 VAL F CG2 1 
ATOM   2474 N N   . ASP A 1 350 ? 177.93600 348.84600 43.15500  1.000 43.10043  ? 385 ASP F N   1 
ATOM   2475 C CA  . ASP A 1 350 ? 178.82600 349.87900 43.69900  1.000 41.83250  ? 385 ASP F CA  1 
ATOM   2476 C C   . ASP A 1 350 ? 179.84900 350.21100 42.61700  1.000 42.40966  ? 385 ASP F C   1 
ATOM   2477 O O   . ASP A 1 350 ? 180.84100 349.48800 42.50100  1.000 45.06112  ? 385 ASP F O   1 
ATOM   2478 C CB  . ASP A 1 350 ? 179.51400 349.47300 44.99400  1.000 46.12843  ? 385 ASP F CB  1 
ATOM   2479 C CG  . ASP A 1 350 ? 180.42300 350.59100 45.55200  1.000 53.38656  ? 385 ASP F CG  1 
ATOM   2480 O OD1 . ASP A 1 350 ? 180.20600 351.78700 45.20500  1.000 49.74657  ? 385 ASP F OD1 1 
ATOM   2481 O OD2 . ASP A 1 350 ? 181.37400 350.26700 46.31200  1.000 50.57737  ? 385 ASP F OD2 1 
ATOM   2482 N N   . ILE A 1 351 ? 179.65000 351.28000 41.84600  1.000 39.02331  ? 386 ILE F N   1 
ATOM   2483 C CA  . ILE A 1 351 ? 180.61400 351.50800 40.76800  1.000 39.48932  ? 386 ILE F CA  1 
ATOM   2484 C C   . ILE A 1 351 ? 182.03800 351.78500 41.31100  1.000 36.38863  ? 386 ILE F C   1 
ATOM   2485 O O   . ILE A 1 351 ? 183.01800 351.66100 40.57300  1.000 37.17526  ? 386 ILE F O   1 
ATOM   2486 C CB  . ILE A 1 351 ? 180.06300 352.67400 39.89300  1.000 37.68237  ? 386 ILE F CB  1 
ATOM   2487 C CG1 . ILE A 1 351 ? 180.80200 352.83200 38.57500  1.000 31.30580  ? 386 ILE F CG1 1 
ATOM   2488 C CG2 . ILE A 1 351 ? 180.17500 353.98500 40.62100  1.000 39.08919  ? 386 ILE F CG2 1 
ATOM   2489 C CD1 . ILE A 1 351 ? 180.27300 351.96700 37.51100  1.000 36.05448  ? 386 ILE F CD1 1 
ATOM   2490 N N   . PHE A 1 352 ? 182.15300 352.23600 42.55600  1.000 41.34227  ? 387 PHE F N   1 
ATOM   2491 C CA  . PHE A 1 352 ? 183.36500 352.61400 43.30500  1.000 47.43673  ? 387 PHE F CA  1 
ATOM   2492 C C   . PHE A 1 352 ? 184.07400 351.47200 44.08500  1.000 48.99971  ? 387 PHE F C   1 
ATOM   2493 O O   . PHE A 1 352 ? 185.09000 351.73900 44.74000  1.000 50.78535  ? 387 PHE F O   1 
ATOM   2494 C CB  . PHE A 1 352 ? 183.03900 353.80700 44.19200  1.000 45.52712  ? 387 PHE F CB  1 
ATOM   2495 C CG  . PHE A 1 352 ? 182.88200 355.06900 43.40500  1.000 41.77412  ? 387 PHE F CG  1 
ATOM   2496 C CD1 . PHE A 1 352 ? 183.80300 355.38600 42.42000  1.000 43.91887  ? 387 PHE F CD1 1 
ATOM   2497 C CD2 . PHE A 1 352 ? 181.76400 355.88100 43.56100  1.000 45.38772  ? 387 PHE F CD2 1 
ATOM   2498 C CE1 . PHE A 1 352 ? 183.66100 356.53700 41.64900  1.000 42.64099  ? 387 PHE F CE1 1 
ATOM   2499 C CE2 . PHE A 1 352 ? 181.60300 357.02900 42.78900  1.000 41.25211  ? 387 PHE F CE2 1 
ATOM   2500 C CZ  . PHE A 1 352 ? 182.55900 357.35800 41.83000  1.000 40.14439  ? 387 PHE F CZ  1 
ATOM   2501 N N   . ASN A 1 353 ? 183.72900 350.22600 43.85000  1.000 44.17692  ? 388 ASN F N   1 
ATOM   2502 C CA  . ASN A 1 353 ? 184.20400 349.04800 44.58800  1.000 44.94211  ? 388 ASN F CA  1 
ATOM   2503 C C   . ASN A 1 353 ? 185.57200 348.59700 44.09900  1.000 48.68286  ? 388 ASN F C   1 
ATOM   2504 O O   . ASN A 1 353 ? 185.81100 348.55500 42.89400  1.000 51.69374  ? 388 ASN F O   1 
ATOM   2505 C CB  . ASN A 1 353 ? 183.22700 347.89500 44.41400  1.000 44.66087  ? 388 ASN F CB  1 
ATOM   2506 C CG  . ASN A 1 353 ? 183.36700 347.23400 43.03800  1.000 44.10829  ? 388 ASN F CG  1 
ATOM   2507 O OD1 . ASN A 1 353 ? 183.86100 346.11500 42.91700  1.000 49.58168  ? 388 ASN F OD1 1 
ATOM   2508 N ND2 . ASN A 1 353 ? 182.98300 347.95500 41.99400  1.000 43.40306  ? 388 ASN F ND2 1 
ATOM   2509 N N   . PRO A 1 354 ? 186.54800 348.46800 45.00100  1.000 50.93312  ? 389 PRO F N   1 
ATOM   2510 C CA  . PRO A 1 354 ? 187.88900 348.06700 44.57700  1.000 50.53798  ? 389 PRO F CA  1 
ATOM   2511 C C   . PRO A 1 354 ? 188.02300 346.64900 44.08000  1.000 49.89431  ? 389 PRO F C   1 
ATOM   2512 O O   . PRO A 1 354 ? 189.09000 346.34300 43.53400  1.000 55.60290  ? 389 PRO F O   1 
ATOM   2513 C CB  . PRO A 1 354 ? 188.68300 348.15100 45.88300  1.000 48.48652  ? 389 PRO F CB  1 
ATOM   2514 C CG  . PRO A 1 354 ? 187.58700 348.36700 47.00500  1.000 49.01832  ? 389 PRO F CG  1 
ATOM   2515 C CD  . PRO A 1 354 ? 186.29200 348.00600 46.38300  1.000 42.70255  ? 389 PRO F CD  1 
ATOM   2516 N N   . LYS A 1 355 ? 187.02900 345.76600 44.22500  1.000 44.67357  ? 390 LYS F N   1 
ATOM   2517 C CA  . LYS A 1 355 ? 187.30300 344.42800 43.72100  1.000 48.81152  ? 390 LYS F CA  1 
ATOM   2518 C C   . LYS A 1 355 ? 187.36700 344.38700 42.19600  1.000 46.52922  ? 390 LYS F C   1 
ATOM   2519 O O   . LYS A 1 355 ? 188.12200 343.58300 41.63500  1.000 49.92046  ? 390 LYS F O   1 
ATOM   2520 C CB  . LYS A 1 355 ? 186.19700 343.48300 44.21900  1.000 47.51246  ? 390 LYS F CB  1 
ATOM   2521 C CG  . LYS A 1 355 ? 186.15500 343.24800 45.74100  1.000 45.77590  ? 390 LYS F CG  1 
ATOM   2522 C CD  . LYS A 1 355 ? 184.99400 342.32100 46.11800  1.000 46.98902  ? 390 LYS F CD  1 
ATOM   2523 C CE  . LYS A 1 355 ? 185.34100 341.26000 47.15400  1.000 47.80994  ? 390 LYS F CE  1 
ATOM   2524 N NZ  . LYS A 1 355 ? 185.43900 339.88300 46.52500  1.000 48.09436  ? 390 LYS F NZ  1 
ATOM   2525 N N   . TYR A 1 356 ? 186.63600 345.27900 41.51000  1.000 43.30483  ? 391 TYR F N   1 
ATOM   2526 C CA  . TYR A 1 356 ? 186.66500 345.36000 40.05200  1.000 42.40131  ? 391 TYR F CA  1 
ATOM   2527 C C   . TYR A 1 356 ? 186.76700 346.79000 39.53300  1.000 41.09430  ? 391 TYR F C   1 
ATOM   2528 O O   . TYR A 1 356 ? 186.00500 347.66300 39.95200  1.000 39.98595  ? 391 TYR F O   1 
ATOM   2529 C CB  . TYR A 1 356 ? 185.43000 344.65500 39.44400  1.000 39.12692  ? 391 TYR F CB  1 
ATOM   2530 C CG  . TYR A 1 356 ? 185.47000 344.49300 37.92700  1.000 40.70232  ? 391 TYR F CG  1 
ATOM   2531 C CD1 . TYR A 1 356 ? 186.13300 343.42900 37.31700  1.000 41.13387  ? 391 TYR F CD1 1 
ATOM   2532 C CD2 . TYR A 1 356 ? 184.84000 345.41300 37.10300  1.000 39.38327  ? 391 TYR F CD2 1 
ATOM   2533 C CE1 . TYR A 1 356 ? 186.17000 343.30700 35.91700  1.000 38.33237  ? 391 TYR F CE1 1 
ATOM   2534 C CE2 . TYR A 1 356 ? 184.86600 345.30100 35.72200  1.000 37.65656  ? 391 TYR F CE2 1 
ATOM   2535 C CZ  . TYR A 1 356 ? 185.52600 344.25800 35.12900  1.000 39.68847  ? 391 TYR F CZ  1 
ATOM   2536 O OH  . TYR A 1 356 ? 185.52500 344.19800 33.73800  1.000 43.65565  ? 391 TYR F OH  1 
ATOM   2537 N N   . ASP A 1 357 ? 187.66700 347.01000 38.59700  1.000 39.22315  ? 392 ASP F N   1 
ATOM   2538 C CA  . ASP A 1 357 ? 187.93600 348.30000 37.95800  1.000 43.16635  ? 392 ASP F CA  1 
ATOM   2539 C C   . ASP A 1 357 ? 186.82900 348.56700 36.93000  1.000 42.94967  ? 392 ASP F C   1 
ATOM   2540 O O   . ASP A 1 357 ? 186.99900 348.32000 35.73100  1.000 45.93121  ? 392 ASP F O   1 
ATOM   2541 C CB  . ASP A 1 357 ? 189.34200 348.40100 37.41200  1.000 51.34418  ? 392 ASP F CB  1 
ATOM   2542 C CG  . ASP A 1 357 ? 189.82800 349.83300 37.44400  1.000 60.13887  ? 392 ASP F CG  1 
ATOM   2543 O OD1 . ASP A 1 357 ? 189.25700 350.64600 38.23300  1.000 56.60693  ? 392 ASP F OD1 1 
ATOM   2544 O OD2 . ASP A 1 357 ? 190.81500 350.12800 36.74000  1.000 62.06965  ? 392 ASP F OD2 1 
ATOM   2545 N N   . CYS A 1 358 ? 185.74200 349.19400 37.38500  1.000 41.55667  ? 393 CYS F N   1 
ATOM   2546 C CA  . CYS A 1 358 ? 184.58000 349.59200 36.57300  1.000 40.77036  ? 393 CYS F CA  1 
ATOM   2547 C C   . CYS A 1 358 ? 184.89600 350.73400 35.63200  1.000 40.19339  ? 393 CYS F C   1 
ATOM   2548 O O   . CYS A 1 358 ? 185.35400 351.79400 36.04700  1.000 49.51193  ? 393 CYS F O   1 
ATOM   2549 C CB  . CYS A 1 358 ? 183.39300 350.00000 37.44000  1.000 37.23501  ? 393 CYS F CB  1 
ATOM   2550 S SG  . CYS A 1 358 ? 182.81200 348.82500 38.61300  1.000 42.83326  ? 393 CYS F SG  1 
ATOM   2551 N N   . LYS A 1 359 ? 184.86500 350.41400 34.34400  1.000 40.31551  ? 394 LYS F N   1 
ATOM   2552 C CA  . LYS A 1 359 ? 185.33700 351.29700 33.29600  1.000 44.65649  ? 394 LYS F CA  1 
ATOM   2553 C C   . LYS A 1 359 ? 184.21800 352.19800 32.78600  1.000 44.32230  ? 394 LYS F C   1 
ATOM   2554 O O   . LYS A 1 359 ? 183.04100 351.82100 32.74100  1.000 39.19940  ? 394 LYS F O   1 
ATOM   2555 C CB  . LYS A 1 359 ? 185.89100 350.49200 32.11400  1.000 49.26407  ? 394 LYS F CB  1 
ATOM   2556 C CG  . LYS A 1 359 ? 187.09200 349.61100 32.43900  1.000 54.90881  ? 394 LYS F CG  1 
ATOM   2557 C CD  . LYS A 1 359 ? 187.47500 348.71700 31.26200  1.000 54.78488  ? 394 LYS F CD  1 
ATOM   2558 C CE  . LYS A 1 359 ? 186.28300 347.95500 30.71500  1.000 56.51726  ? 394 LYS F CE  1 
ATOM   2559 N NZ  . LYS A 1 359 ? 186.53900 347.52500 29.29100  1.000 66.46410  ? 394 LYS F NZ  1 
ATOM   2560 N N   . ILE A 1 360 ? 184.62300 353.41800 32.41500  1.000 44.52886  ? 395 ILE F N   1 
ATOM   2561 C CA  . ILE A 1 360 ? 183.75700 354.46500 31.90000  1.000 41.33415  ? 395 ILE F CA  1 
ATOM   2562 C C   . ILE A 1 360 ? 184.45500 355.12200 30.71900  1.000 40.44455  ? 395 ILE F C   1 
ATOM   2563 O O   . ILE A 1 360 ? 185.64000 354.91500 30.47600  1.000 44.32531  ? 395 ILE F O   1 
ATOM   2564 C CB  . ILE A 1 360 ? 183.42200 355.50800 32.98500  1.000 37.55156  ? 395 ILE F CB  1 
ATOM   2565 C CG1 . ILE A 1 360 ? 184.69100 356.20600 33.42200  1.000 38.89219  ? 395 ILE F CG1 1 
ATOM   2566 C CG2 . ILE A 1 360 ? 182.72200 354.88100 34.17000  1.000 34.54604  ? 395 ILE F CG2 1 
ATOM   2567 C CD1 . ILE A 1 360 ? 184.41100 357.46200 34.18400  1.000 37.54866  ? 395 ILE F CD1 1 
ATOM   2568 N N   . MET A 1 361 ? 183.69900 355.92800 29.99200  1.000 38.25412  ? 396 MET F N   1 
ATOM   2569 C CA  . MET A 1 361 ? 184.22000 356.80800 28.96200  1.000 40.22198  ? 396 MET F CA  1 
ATOM   2570 C C   . MET A 1 361 ? 183.70400 358.20400 29.27200  1.000 40.66253  ? 396 MET F C   1 
ATOM   2571 O O   . MET A 1 361 ? 182.64900 358.37200 29.88800  1.000 45.21716  ? 396 MET F O   1 
ATOM   2572 C CB  . MET A 1 361 ? 183.81300 356.34800 27.56500  1.000 40.22213  ? 396 MET F CB  1 
ATOM   2573 C CG  . MET A 1 361 ? 182.31800 356.35400 27.33100  1.000 46.29646  ? 396 MET F CG  1 
ATOM   2574 S SD  . MET A 1 361 ? 181.71700 355.97800 25.64900  1.000 75.63428  ? 396 MET F SD  1 
ATOM   2575 C CE  . MET A 1 361 ? 180.90500 354.40800 25.86100  1.000 47.02495  ? 396 MET F CE  1 
ATOM   2576 N N   . THR A 1 362 ? 184.49900 359.20200 28.95300  1.000 39.53351  ? 397 THR F N   1 
ATOM   2577 C CA  . THR A 1 362 ? 184.18000 360.57600 29.28400  1.000 39.88585  ? 397 THR F CA  1 
ATOM   2578 C C   . THR A 1 362 ? 184.11800 361.42100 28.02800  1.000 44.39590  ? 397 THR F C   1 
ATOM   2579 O O   . THR A 1 362 ? 184.60600 361.02600 26.96200  1.000 48.07856  ? 397 THR F O   1 
ATOM   2580 C CB  . THR A 1 362 ? 185.23900 361.18000 30.22600  1.000 40.25396  ? 397 THR F CB  1 
ATOM   2581 O OG1 . THR A 1 362 ? 186.51800 361.17700 29.57600  1.000 42.68201  ? 397 THR F OG1 1 
ATOM   2582 C CG2 . THR A 1 362 ? 185.35700 360.33700 31.48900  1.000 33.05768  ? 397 THR F CG2 1 
ATOM   2583 N N   . SER A 1 363 ? 183.39300 362.52800 28.13400  1.000 46.70204  ? 398 SER F N   1 
ATOM   2584 C CA  . SER A 1 363 ? 183.32200 363.47200 27.01800  1.000 47.41144  ? 398 SER F CA  1 
ATOM   2585 C C   . SER A 1 363 ? 182.69200 364.75900 27.52900  1.000 50.80888  ? 398 SER F C   1 
ATOM   2586 O O   . SER A 1 363 ? 182.47100 364.92900 28.73100  1.000 49.27658  ? 398 SER F O   1 
ATOM   2587 C CB  . SER A 1 363 ? 182.50200 362.94000 25.85400  1.000 50.11585  ? 398 SER F CB  1 
ATOM   2588 O OG  . SER A 1 363 ? 181.14400 362.96500 26.23000  1.000 52.25189  ? 398 SER F OG  1 
ATOM   2589 N N   . LYS A 1 364 ? 182.49300 365.70900 26.61800  1.000 55.69480  ? 399 LYS F N   1 
ATOM   2590 C CA  . LYS A 1 364 ? 181.74600 366.92600 26.91400  1.000 50.66891  ? 399 LYS F CA  1 
ATOM   2591 C C   . LYS A 1 364 ? 180.60100 367.02800 25.90900  1.000 55.04083  ? 399 LYS F C   1 
ATOM   2592 O O   . LYS A 1 364 ? 180.09400 368.11800 25.61800  1.000 53.52712  ? 399 LYS F O   1 
ATOM   2593 C CB  . LYS A 1 364 ? 182.63800 368.17200 26.91200  1.000 48.34535  ? 399 LYS F CB  1 
ATOM   2594 C CG  . LYS A 1 364 ? 183.73100 368.12300 28.00100  1.000 59.69909  ? 399 LYS F CG  1 
ATOM   2595 C CD  . LYS A 1 364 ? 184.78400 369.25600 27.94600  1.000 65.29680  ? 399 LYS F CD  1 
ATOM   2596 C CE  . LYS A 1 364 ? 184.29300 370.66900 28.26800  1.000 62.82911  ? 399 LYS F CE  1 
ATOM   2597 N NZ  . LYS A 1 364 ? 183.85900 370.80700 29.69800  1.000 61.73463  ? 399 LYS F NZ  1 
ATOM   2598 N N   . THR A 1 365 ? 180.13900 365.86900 25.42600  1.000 52.02630  ? 400 THR F N   1 
ATOM   2599 C CA  . THR A 1 365 ? 179.13000 365.81100 24.37500  1.000 58.27030  ? 400 THR F CA  1 
ATOM   2600 C C   . THR A 1 365 ? 177.79500 365.46900 25.02100  1.000 50.03863  ? 400 THR F C   1 
ATOM   2601 O O   . THR A 1 365 ? 177.43600 364.31200 25.24400  1.000 49.96957  ? 400 THR F O   1 
ATOM   2602 C CB  . THR A 1 365 ? 179.52300 364.83000 23.27900  1.000 65.69696  ? 400 THR F CB  1 
ATOM   2603 O OG1 . THR A 1 365 ? 180.82100 365.19500 22.77500  1.000 66.44435  ? 400 THR F OG1 1 
ATOM   2604 C CG2 . THR A 1 365 ? 178.48700 364.88800 22.12700  1.000 62.66999  ? 400 THR F CG2 1 
ATOM   2605 N N   . ASP A 1 366 ? 177.05900 366.52000 25.32700  1.000 47.60278  ? 401 ASP F N   1 
ATOM   2606 C CA  . ASP A 1 366 ? 175.77300 366.39700 25.97600  1.000 48.69737  ? 401 ASP F CA  1 
ATOM   2607 C C   . ASP A 1 366 ? 174.68100 366.40800 24.90500  1.000 53.68318  ? 401 ASP F C   1 
ATOM   2608 O O   . ASP A 1 366 ? 174.01500 367.41400 24.64600  1.000 60.88440  ? 401 ASP F O   1 
ATOM   2609 C CB  . ASP A 1 366 ? 175.60000 367.49700 27.04100  1.000 56.78240  ? 401 ASP F CB  1 
ATOM   2610 C CG  . ASP A 1 366 ? 175.92200 368.91100 26.53100  1.000 64.39761  ? 401 ASP F CG  1 
ATOM   2611 O OD1 . ASP A 1 366 ? 176.70300 369.06900 25.56400  1.000 66.58620  ? 401 ASP F OD1 1 
ATOM   2612 O OD2 . ASP A 1 366 ? 175.38000 369.87400 27.11800  1.000 66.56453  ? 401 ASP F OD2 1 
ATOM   2613 N N   . VAL A 1 367 ? 174.51200 365.24200 24.26900  1.000 48.40305  ? 402 VAL F N   1 
ATOM   2614 C CA  . VAL A 1 367 ? 173.46200 365.01500 23.28200  1.000 39.52043  ? 402 VAL F CA  1 
ATOM   2615 C C   . VAL A 1 367 ? 172.42600 364.09200 23.88600  1.000 38.65966  ? 402 VAL F C   1 
ATOM   2616 O O   . VAL A 1 367 ? 172.75300 363.06600 24.49800  1.000 37.25058  ? 402 VAL F O   1 
ATOM   2617 C CB  . VAL A 1 367 ? 174.00800 364.41400 21.97300  1.000 44.56011  ? 402 VAL F CB  1 
ATOM   2618 C CG1 . VAL A 1 367 ? 172.89400 363.99300 21.07000  1.000 42.52168  ? 402 VAL F CG1 1 
ATOM   2619 C CG2 . VAL A 1 367 ? 174.66200 365.50900 21.21800  1.000 56.52372  ? 402 VAL F CG2 1 
ATOM   2620 N N   . SER A 1 368 ? 171.16700 364.47100 23.69400  1.000 40.03800  ? 403 SER F N   1 
ATOM   2621 C CA  . SER A 1 368 ? 170.05900 363.73100 24.26000  1.000 34.57904  ? 403 SER F CA  1 
ATOM   2622 C C   . SER A 1 368 ? 169.86700 362.41600 23.52100  1.000 32.52370  ? 403 SER F C   1 
ATOM   2623 O O   . SER A 1 368 ? 169.98700 362.35400 22.29900  1.000 33.69211  ? 403 SER F O   1 
ATOM   2624 C CB  . SER A 1 368 ? 168.80500 364.60000 24.19300  1.000 32.23539  ? 403 SER F CB  1 
ATOM   2625 O OG  . SER A 1 368 ? 168.98400 365.73900 25.00600  1.000 32.07745  ? 403 SER F OG  1 
ATOM   2626 N N   . SER A 1 369 ? 169.42900 361.39800 24.25200  1.000 32.65354  ? 404 SER F N   1 
ATOM   2627 C CA  . SER A 1 369 ? 169.18100 360.08300 23.67300  1.000 29.56171  ? 404 SER F CA  1 
ATOM   2628 C C   . SER A 1 369 ? 168.30800 359.27300 24.61700  1.000 29.04518  ? 404 SER F C   1 
ATOM   2629 O O   . SER A 1 369 ? 168.12900 359.60000 25.79600  1.000 24.87392  ? 404 SER F O   1 
ATOM   2630 C CB  . SER A 1 369 ? 170.48700 359.33300 23.34200  1.000 29.78998  ? 404 SER F CB  1 
ATOM   2631 O OG  . SER A 1 369 ? 171.29900 359.13100 24.48700  1.000 31.55827  ? 404 SER F OG  1 
ATOM   2632 N N   . SER A 1 370 ? 167.85300 358.14900 24.10300  1.000 30.03705  ? 405 SER F N   1 
ATOM   2633 C CA  . SER A 1 370 ? 167.06900 357.23300 24.89500  1.000 29.46422  ? 405 SER F CA  1 
ATOM   2634 C C   . SER A 1 370 ? 167.46400 355.79800 24.57600  1.000 30.57143  ? 405 SER F C   1 
ATOM   2635 O O   . SER A 1 370 ? 167.94700 355.48800 23.48000  1.000 34.59448  ? 405 SER F O   1 
ATOM   2636 C CB  . SER A 1 370 ? 165.58500 357.45700 24.63000  1.000 29.85835  ? 405 SER F CB  1 
ATOM   2637 O OG  . SER A 1 370 ? 164.80300 356.57100 25.40600  1.000 30.38578  ? 405 SER F OG  1 
ATOM   2638 N N   . VAL A 1 371 ? 167.26900 354.92600 25.55800  1.000 22.79993  ? 406 VAL F N   1 
ATOM   2639 C CA  . VAL A 1 371 ? 167.53200 353.51200 25.39800  1.000 22.51548  ? 406 VAL F CA  1 
ATOM   2640 C C   . VAL A 1 371 ? 166.28500 352.77600 25.83000  1.000 24.78119  ? 406 VAL F C   1 
ATOM   2641 O O   . VAL A 1 371 ? 165.86500 352.88000 26.98600  1.000 27.50753  ? 406 VAL F O   1 
ATOM   2642 C CB  . VAL A 1 371 ? 168.70200 353.00200 26.25400  1.000 20.05783  ? 406 VAL F CB  1 
ATOM   2643 C CG1 . VAL A 1 371 ? 168.84900 351.49900 26.05300  1.000 20.94717  ? 406 VAL F CG1 1 
ATOM   2644 C CG2 . VAL A 1 371 ? 169.95400 353.69100 25.92700  1.000 24.61497  ? 406 VAL F CG2 1 
ATOM   2645 N N   . ILE A 1 372 ? 165.72100 351.99500 24.92400  1.000 27.44582  ? 407 ILE F N   1 
ATOM   2646 C CA  . ILE A 1 372 ? 164.58300 351.15900 25.27200  1.000 27.77505  ? 407 ILE F CA  1 
ATOM   2647 C C   . ILE A 1 372 ? 165.14600 349.91600 25.94100  1.000 30.21057  ? 407 ILE F C   1 
ATOM   2648 O O   . ILE A 1 372 ? 165.86700 349.13100 25.30800  1.000 35.51932  ? 407 ILE F O   1 
ATOM   2649 C CB  . ILE A 1 372 ? 163.75300 350.80100 24.03200  1.000 30.30620  ? 407 ILE F CB  1 
ATOM   2650 C CG1 . ILE A 1 372 ? 163.14200 352.06800 23.42100  1.000 26.49075  ? 407 ILE F CG1 1 
ATOM   2651 C CG2 . ILE A 1 372 ? 162.72500 349.70100 24.36300  1.000 34.94369  ? 407 ILE F CG2 1 
ATOM   2652 C CD1 . ILE A 1 372 ? 162.24300 352.81800 24.39000  1.000 28.91733  ? 407 ILE F CD1 1 
ATOM   2653 N N   . THR A 1 373 ? 164.82000 349.72800 27.21500  1.000 29.69602  ? 408 THR F N   1 
ATOM   2654 C CA  . THR A 1 373 ? 165.30900 348.58000 27.96900  1.000 29.05097  ? 408 THR F CA  1 
ATOM   2655 C C   . THR A 1 373 ? 164.26600 347.46800 27.85900  1.000 30.83102  ? 408 THR F C   1 
ATOM   2656 O O   . THR A 1 373 ? 163.40600 347.49300 26.97300  1.000 32.14556  ? 408 THR F O   1 
ATOM   2657 C CB  . THR A 1 373 ? 165.61900 348.95900 29.42500  1.000 27.71853  ? 408 THR F CB  1 
ATOM   2658 O OG1 . THR A 1 373 ? 164.41200 349.26200 30.15800  1.000 28.93455  ? 408 THR F OG1 1 
ATOM   2659 C CG2 . THR A 1 373 ? 166.58700 350.12100 29.50900  1.000 24.94366  ? 408 THR F CG2 1 
ATOM   2660 N N   . SER A 1 374 ? 164.40300 346.41000 28.66100  1.000 29.13498  ? 409 SER F N   1 
ATOM   2661 C CA  . SER A 1 374 ? 163.43600 345.32400 28.56800  1.000 30.58799  ? 409 SER F CA  1 
ATOM   2662 C C   . SER A 1 374 ? 162.10000 345.68800 29.21500  1.000 30.40041  ? 409 SER F C   1 
ATOM   2663 O O   . SER A 1 374 ? 161.04100 345.33300 28.68700  1.000 34.67102  ? 409 SER F O   1 
ATOM   2664 C CB  . SER A 1 374 ? 163.99600 344.03700 29.18600  1.000 31.38039  ? 409 SER F CB  1 
ATOM   2665 O OG  . SER A 1 374 ? 165.25200 343.68200 28.63800  1.000 31.26795  ? 409 SER F OG  1 
ATOM   2666 N N   . LEU A 1 375 ? 162.12200 346.48200 30.27400  1.000 26.77994  ? 410 LEU F N   1 
ATOM   2667 C CA  . LEU A 1 375 ? 160.91300 346.81100 31.01100  1.000 29.28546  ? 410 LEU F CA  1 
ATOM   2668 C C   . LEU A 1 375 ? 160.68300 348.30400 31.18000  1.000 32.76258  ? 410 LEU F C   1 
ATOM   2669 O O   . LEU A 1 375 ? 159.93500 348.69500 32.07300  1.000 34.62024  ? 410 LEU F O   1 
ATOM   2670 C CB  . LEU A 1 375 ? 160.96700 346.16200 32.38700  1.000 31.77958  ? 410 LEU F CB  1 
ATOM   2671 C CG  . LEU A 1 375 ? 161.05300 344.63600 32.35300  1.000 31.90471  ? 410 LEU F CG  1 
ATOM   2672 C CD1 . LEU A 1 375 ? 161.20500 344.05900 33.77600  1.000 33.88495  ? 410 LEU F CD1 1 
ATOM   2673 C CD2 . LEU A 1 375 ? 159.83400 344.08300 31.66500  1.000 35.67245  ? 410 LEU F CD2 1 
ATOM   2674 N N   . GLY A 1 376 ? 161.34300 349.15300 30.40200  1.000 31.51907  ? 411 GLY F N   1 
ATOM   2675 C CA  . GLY A 1 376 ? 161.13900 350.57700 30.56000  1.000 28.86953  ? 411 GLY F CA  1 
ATOM   2676 C C   . GLY A 1 376 ? 162.00800 351.34700 29.59900  1.000 28.39889  ? 411 GLY F C   1 
ATOM   2677 O O   . GLY A 1 376 ? 162.25100 350.86800 28.49200  1.000 30.02257  ? 411 GLY F O   1 
ATOM   2678 N N   . ALA A 1 377 ? 162.50700 352.51700 30.00400  1.000 28.85550  ? 412 ALA F N   1 
ATOM   2679 C CA  . ALA A 1 377 ? 163.32400 353.32900 29.10500  1.000 27.07685  ? 412 ALA F CA  1 
ATOM   2680 C C   . ALA A 1 377 ? 164.21000 354.28100 29.89000  1.000 28.39371  ? 412 ALA F C   1 
ATOM   2681 O O   . ALA A 1 377 ? 163.75700 354.91000 30.86000  1.000 30.99543  ? 412 ALA F O   1 
ATOM   2682 C CB  . ALA A 1 377 ? 162.47100 354.14500 28.13100  1.000 22.36381  ? 412 ALA F CB  1 
ATOM   2683 N N   . ILE A 1 378 ? 165.48600 354.31200 29.52000  1.000 23.50609  ? 413 ILE F N   1 
ATOM   2684 C CA  . ILE A 1 378 ? 166.40900 355.31300 30.02100  1.000 25.54430  ? 413 ILE F CA  1 
ATOM   2685 C C   . ILE A 1 378 ? 166.39700 356.50400 29.08900  1.000 27.00858  ? 413 ILE F C   1 
ATOM   2686 O O   . ILE A 1 378 ? 166.36500 356.34700 27.86200  1.000 27.34663  ? 413 ILE F O   1 
ATOM   2687 C CB  . ILE A 1 378 ? 167.84500 354.77700 30.16200  1.000 28.59366  ? 413 ILE F CB  1 
ATOM   2688 C CG1 . ILE A 1 378 ? 167.90600 353.49000 30.95700  1.000 27.00076  ? 413 ILE F CG1 1 
ATOM   2689 C CG2 . ILE A 1 378 ? 168.78000 355.85600 30.69600  1.000 27.06280  ? 413 ILE F CG2 1 
ATOM   2690 C CD1 . ILE A 1 378 ? 169.34000 352.96900 30.98000  1.000 24.87124  ? 413 ILE F CD1 1 
ATOM   2691 N N   . VAL A 1 379 ? 166.38400 357.69800 29.67100  1.000 23.76715  ? 414 VAL F N   1 
ATOM   2692 C CA  . VAL A 1 379 ? 166.37700 358.93900 28.92400  1.000 20.78330  ? 414 VAL F CA  1 
ATOM   2693 C C   . VAL A 1 379 ? 167.49500 359.83500 29.44500  1.000 24.12029  ? 414 VAL F C   1 
ATOM   2694 O O   . VAL A 1 379 ? 167.55900 360.12600 30.64600  1.000 23.26425  ? 414 VAL F O   1 
ATOM   2695 C CB  . VAL A 1 379 ? 165.02300 359.65400 28.97500  1.000 23.43789  ? 414 VAL F CB  1 
ATOM   2696 C CG1 . VAL A 1 379 ? 165.15700 360.99100 28.31200  1.000 23.31194  ? 414 VAL F CG1 1 
ATOM   2697 C CG2 . VAL A 1 379 ? 163.96100 358.82800 28.22700  1.000 24.43851  ? 414 VAL F CG2 1 
ATOM   2698 N N   . SER A 1 380 ? 168.39900 360.23700 28.56600  1.000 25.45690  ? 415 SER F N   1 
ATOM   2699 C CA  . SER A 1 380 ? 169.41000 361.23900 28.89600  1.000 28.03828  ? 415 SER F CA  1 
ATOM   2700 C C   . SER A 1 380 ? 168.97900 362.51300 28.18000  1.000 27.04308  ? 415 SER F C   1 
ATOM   2701 O O   . SER A 1 380 ? 169.01500 362.58100 26.94200  1.000 26.39247  ? 415 SER F O   1 
ATOM   2702 C CB  . SER A 1 380 ? 170.84600 360.86100 28.50600  1.000 27.25892  ? 415 SER F CB  1 
ATOM   2703 O OG  . SER A 1 380 ? 171.33700 359.72800 29.16800  1.000 24.52098  ? 415 SER F OG  1 
ATOM   2704 N N   . CYS A 1 381 ? 168.48000 363.47700 28.95200  1.000 26.11095  ? 416 CYS F N   1 
ATOM   2705 C CA  . CYS A 1 381 ? 167.94000 364.72400 28.41600  1.000 29.45434  ? 416 CYS F CA  1 
ATOM   2706 C C   . CYS A 1 381 ? 168.86100 365.88900 28.77500  1.000 29.62655  ? 416 CYS F C   1 
ATOM   2707 O O   . CYS A 1 381 ? 169.14300 366.11200 29.96100  1.000 29.65842  ? 416 CYS F O   1 
ATOM   2708 C CB  . CYS A 1 381 ? 166.54200 364.97700 28.97900  1.000 26.81033  ? 416 CYS F CB  1 
ATOM   2709 S SG  . CYS A 1 381 ? 165.52200 365.98800 27.94400  1.000 35.63214  ? 416 CYS F SG  1 
ATOM   2710 N N   . TYR A 1 382 ? 169.28300 366.65900 27.75900  1.000 26.23506  ? 417 TYR F N   1 
ATOM   2711 C CA  . TYR A 1 382 ? 170.18700 367.79400 27.96200  1.000 30.10044  ? 417 TYR F CA  1 
ATOM   2712 C C   . TYR A 1 382 ? 169.83700 368.95800 27.03100  1.000 30.34227  ? 417 TYR F C   1 
ATOM   2713 O O   . TYR A 1 382 ? 169.26100 368.77800 25.95100  1.000 29.51273  ? 417 TYR F O   1 
ATOM   2714 C CB  . TYR A 1 382 ? 171.67300 367.38500 27.76800  1.000 31.80020  ? 417 TYR F CB  1 
ATOM   2715 C CG  . TYR A 1 382 ? 172.04400 366.21600 28.61900  1.000 27.16381  ? 417 TYR F CG  1 
ATOM   2716 C CD1 . TYR A 1 382 ? 172.21200 366.38400 29.98200  1.000 28.14518  ? 417 TYR F CD1 1 
ATOM   2717 C CD2 . TYR A 1 382 ? 172.17600 364.93100 28.08100  1.000 30.42004  ? 417 TYR F CD2 1 
ATOM   2718 C CE1 . TYR A 1 382 ? 172.51000 365.32100 30.81200  1.000 30.92774  ? 417 TYR F CE1 1 
ATOM   2719 C CE2 . TYR A 1 382 ? 172.48200 363.84700 28.89900  1.000 27.93116  ? 417 TYR F CE2 1 
ATOM   2720 C CZ  . TYR A 1 382 ? 172.64800 364.06300 30.27000  1.000 29.14053  ? 417 TYR F CZ  1 
ATOM   2721 O OH  . TYR A 1 382 ? 172.94600 363.04900 31.13200  1.000 28.28216  ? 417 TYR F OH  1 
ATOM   2722 N N   . GLY A 1 383 ? 170.13900 370.17200 27.49300  1.000 27.70166  ? 418 GLY F N   1 
ATOM   2723 C CA  . GLY A 1 383 ? 169.87500 371.32200 26.66000  1.000 29.96768  ? 418 GLY F CA  1 
ATOM   2724 C C   . GLY A 1 383 ? 168.39400 371.67400 26.60900  1.000 28.90275  ? 418 GLY F C   1 
ATOM   2725 O O   . GLY A 1 383 ? 167.65100 371.57000 27.59500  1.000 30.07821  ? 418 GLY F O   1 
ATOM   2726 N N   . LYS A 1 384 ? 167.97200 372.04500 25.40700  1.000 26.20340  ? 419 LYS F N   1 
ATOM   2727 C CA  . LYS A 1 384 ? 166.62300 372.42700 25.02600  1.000 25.10804  ? 419 LYS F CA  1 
ATOM   2728 C C   . LYS A 1 384 ? 165.79100 371.27800 24.47100  1.000 25.76036  ? 419 LYS F C   1 
ATOM   2729 O O   . LYS A 1 384 ? 164.75500 371.50500 23.83800  1.000 28.72555  ? 419 LYS F O   1 
ATOM   2730 C CB  . LYS A 1 384 ? 166.69700 373.59400 24.03100  1.000 26.14919  ? 419 LYS F CB  1 
ATOM   2731 C CG  . LYS A 1 384 ? 167.68300 374.60800 24.45500  1.000 22.80647  ? 419 LYS F CG  1 
ATOM   2732 C CD  . LYS A 1 384 ? 167.50000 375.82500 23.65700  1.000 26.01235  ? 419 LYS F CD  1 
ATOM   2733 C CE  . LYS A 1 384 ? 168.54500 376.84300 23.95300  1.000 34.64101  ? 419 LYS F CE  1 
ATOM   2734 N NZ  . LYS A 1 384 ? 168.10300 377.44600 25.27400  1.000 41.77039  ? 419 LYS F NZ  1 
ATOM   2735 N N   . THR A 1 385 ? 166.25000 370.05900 24.63300  1.000 27.39627  ? 420 THR F N   1 
ATOM   2736 C CA  . THR A 1 385 ? 165.56400 368.92400 24.05200  1.000 25.09836  ? 420 THR F CA  1 
ATOM   2737 C C   . THR A 1 385 ? 164.25800 368.66700 24.78500  1.000 23.69237  ? 420 THR F C   1 
ATOM   2738 O O   . THR A 1 385 ? 164.19700 368.65200 26.01900  1.000 22.23770  ? 420 THR F O   1 
ATOM   2739 C CB  . THR A 1 385 ? 166.46900 367.72500 24.10700  1.000 24.26558  ? 420 THR F CB  1 
ATOM   2740 O OG1 . THR A 1 385 ? 167.73300 368.13800 23.58400  1.000 28.06695  ? 420 THR F OG1 1 
ATOM   2741 C CG2 . THR A 1 385 ? 165.89600 366.56800 23.30300  1.000 24.04997  ? 420 THR F CG2 1 
ATOM   2742 N N   . LYS A 1 386 ? 163.24100 368.33900 24.02000  1.000 21.18970  ? 421 LYS F N   1 
ATOM   2743 C CA  . LYS A 1 386 ? 161.91900 368.07400 24.56000  1.000 22.79461  ? 421 LYS F CA  1 
ATOM   2744 C C   . LYS A 1 386 ? 161.82000 366.57300 24.83400  1.000 27.44130  ? 421 LYS F C   1 
ATOM   2745 O O   . LYS A 1 386 ? 161.82700 365.76400 23.90200  1.000 29.04107  ? 421 LYS F O   1 
ATOM   2746 C CB  . LYS A 1 386 ? 160.84900 368.56300 23.57300  1.000 23.06797  ? 421 LYS F CB  1 
ATOM   2747 C CG  . LYS A 1 386 ? 159.39200 368.23600 24.00300  1.000 30.45485  ? 421 LYS F CG  1 
ATOM   2748 C CD  . LYS A 1 386 ? 158.29200 368.67800 22.99400  1.000 45.70320  ? 421 LYS F CD  1 
ATOM   2749 C CE  . LYS A 1 386 ? 156.82300 368.29000 23.46200  1.000 44.31362  ? 421 LYS F CE  1 
ATOM   2750 N NZ  . LYS A 1 386 ? 156.21000 368.98300 24.68000  1.000 32.64108  ? 421 LYS F NZ  1 
ATOM   2751 N N   . CYS A 1 387 ? 162.01300 366.16900 26.09200  1.000 22.17819  ? 422 CYS F N   1 
ATOM   2752 C CA  . CYS A 1 387 ? 161.89200 364.75200 26.43600  1.000 22.08679  ? 422 CYS F CA  1 
ATOM   2753 C C   . CYS A 1 387 ? 160.60800 364.46200 27.18900  1.000 23.45462  ? 422 CYS F C   1 
ATOM   2754 O O   . CYS A 1 387 ? 160.41900 364.97600 28.29800  1.000 24.77726  ? 422 CYS F O   1 
ATOM   2755 C CB  . CYS A 1 387 ? 163.09400 364.26600 27.22400  1.000 20.00500  ? 422 CYS F CB  1 
ATOM   2756 S SG  . CYS A 1 387 ? 164.61900 364.82100 26.46100  1.000 22.80116  ? 422 CYS F SG  1 
ATOM   2757 N N   . THR A 1 388 ? 159.90900 363.41500 26.76500  1.000 22.52946  ? 423 THR F N   1 
ATOM   2758 C CA  . THR A 1 388 ? 158.61100 363.17200 27.35700  1.000 22.14472  ? 423 THR F CA  1 
ATOM   2759 C C   . THR A 1 388 ? 158.26900 361.67700 27.22500  1.000 27.20354  ? 423 THR F C   1 
ATOM   2760 O O   . THR A 1 388 ? 158.85800 360.95600 26.41900  1.000 27.29185  ? 423 THR F O   1 
ATOM   2761 C CB  . THR A 1 388 ? 157.59700 364.06800 26.62300  1.000 23.93880  ? 423 THR F CB  1 
ATOM   2762 O OG1 . THR A 1 388 ? 156.38100 364.09500 27.33300  1.000 39.38079  ? 423 THR F OG1 1 
ATOM   2763 C CG2 . THR A 1 388 ? 157.23600 363.46300 25.25500  1.000 22.18028  ? 423 THR F CG2 1 
ATOM   2764 N N   . ALA A 1 389 ? 157.29100 361.22200 28.01600  1.000 28.93554  ? 424 ALA F N   1 
ATOM   2765 C CA  . ALA A 1 389 ? 156.76300 359.85200 27.97700  1.000 25.77439  ? 424 ALA F CA  1 
ATOM   2766 C C   . ALA A 1 389 ? 155.23900 359.89300 27.98100  1.000 26.89326  ? 424 ALA F C   1 
ATOM   2767 O O   . ALA A 1 389 ? 154.63200 360.54600 28.84600  1.000 28.33483  ? 424 ALA F O   1 
ATOM   2768 C CB  . ALA A 1 389 ? 157.28700 359.00700 29.14200  1.000 21.67470  ? 424 ALA F CB  1 
ATOM   2769 N N   . SER A 1 390 ? 154.64100 359.25500 26.98100  1.000 26.52410  ? 425 SER F N   1 
ATOM   2770 C CA  . SER A 1 390 ? 153.21200 359.28700 26.71500  1.000 31.68020  ? 425 SER F CA  1 
ATOM   2771 C C   . SER A 1 390 ? 152.53700 357.91200 26.71900  1.000 38.01232  ? 425 SER F C   1 
ATOM   2772 O O   . SER A 1 390 ? 153.17800 356.85300 26.60800  1.000 37.89400  ? 425 SER F O   1 
ATOM   2773 C CB  . SER A 1 390 ? 152.92800 359.96200 25.36200  1.000 34.20691  ? 425 SER F CB  1 
ATOM   2774 O OG  . SER A 1 390 ? 153.50800 361.25700 25.31400  1.000 37.61521  ? 425 SER F OG  1 
ATOM   2775 N N   . ASN A 1 391 ? 151.22600 357.97000 26.97100  1.000 43.28070  ? 426 ASN F N   1 
ATOM   2776 C CA  . ASN A 1 391 ? 150.27700 356.87300 26.81500  1.000 44.81080  ? 426 ASN F CA  1 
ATOM   2777 C C   . ASN A 1 391 ? 149.42500 357.16600 25.57900  1.000 49.00944  ? 426 ASN F C   1 
ATOM   2778 O O   . ASN A 1 391 ? 149.05700 358.32200 25.34000  1.000 49.62220  ? 426 ASN F O   1 
ATOM   2779 C CB  . ASN A 1 391 ? 149.38500 356.79100 28.04900  1.000 49.28048  ? 426 ASN F CB  1 
ATOM   2780 C CG  . ASN A 1 391 ? 148.40800 355.65100 28.00000  1.000 55.12851  ? 426 ASN F CG  1 
ATOM   2781 O OD1 . ASN A 1 391 ? 147.30200 355.79500 27.46000  1.000 54.76089  ? 426 ASN F OD1 1 
ATOM   2782 N ND2 . ASN A 1 391 ? 148.77600 354.52600 28.60300  1.000 57.60466  ? 426 ASN F ND2 1 
ATOM   2783 N N   . LYS A 1 392 ? 149.05900 356.13200 24.80900  1.000 51.69929  ? 427 LYS F N   1 
ATOM   2784 C CA  . LYS A 1 392 ? 148.40000 356.42500 23.53000  1.000 55.04343  ? 427 LYS F CA  1 
ATOM   2785 C C   . LYS A 1 392 ? 147.08600 357.17100 23.73800  1.000 56.34456  ? 427 LYS F C   1 
ATOM   2786 O O   . LYS A 1 392 ? 146.69900 357.99300 22.89500  1.000 57.92198  ? 427 LYS F O   1 
ATOM   2787 C CB  . LYS A 1 392 ? 148.24300 355.19900 22.61300  1.000 56.12498  ? 427 LYS F CB  1 
ATOM   2788 C CG  . LYS A 1 392 ? 147.44300 354.02000 23.06800  1.000 59.29791  ? 427 LYS F CG  1 
ATOM   2789 C CD  . LYS A 1 392 ? 147.69300 352.85600 22.09300  1.000 50.79631  ? 427 LYS F CD  1 
ATOM   2790 C CE  . LYS A 1 392 ? 147.28200 351.51400 22.68900  1.000 44.56572  ? 427 LYS F CE  1 
ATOM   2791 N NZ  . LYS A 1 392 ? 147.46800 351.51500 24.17300  1.000 47.70511  ? 427 LYS F NZ  1 
ATOM   2792 N N   . ASN A 1 393 ? 146.37900 356.89100 24.83800  1.000 54.85652  ? 428 ASN F N   1 
ATOM   2793 C CA  . ASN A 1 393 ? 145.07700 357.50000 25.07100  1.000 52.27732  ? 428 ASN F CA  1 
ATOM   2794 C C   . ASN A 1 393 ? 145.09000 358.61100 26.10800  1.000 54.30766  ? 428 ASN F C   1 
ATOM   2795 O O   . ASN A 1 393 ? 144.18700 359.44800 26.09100  1.000 59.74238  ? 428 ASN F O   1 
ATOM   2796 C CB  . ASN A 1 393 ? 144.06800 356.45400 25.56100  1.000 63.00391  ? 428 ASN F CB  1 
ATOM   2797 C CG  . ASN A 1 393 ? 144.00500 355.21400 24.67700  1.000 69.66428  ? 428 ASN F CG  1 
ATOM   2798 O OD1 . ASN A 1 393 ? 144.51600 354.15200 25.05400  1.000 65.69423  ? 428 ASN F OD1 1 
ATOM   2799 N ND2 . ASN A 1 393 ? 143.34800 355.33400 23.50800  1.000 70.33787  ? 428 ASN F ND2 1 
ATOM   2800 N N   . ARG A 1 394 ? 146.07800 358.67000 26.99500  1.000 50.38671  ? 429 ARG F N   1 
ATOM   2801 C CA  . ARG A 1 394 ? 146.12300 359.76100 27.96300  1.000 45.86696  ? 429 ARG F CA  1 
ATOM   2802 C C   . ARG A 1 394 ? 146.99800 360.93000 27.53600  1.000 44.55526  ? 429 ARG F C   1 
ATOM   2803 O O   . ARG A 1 394 ? 146.80400 362.04100 28.04800  1.000 44.11098  ? 429 ARG F O   1 
ATOM   2804 C CB  . ARG A 1 394 ? 146.57400 359.25500 29.33700  1.000 48.80620  ? 429 ARG F CB  1 
ATOM   2805 C CG  . ARG A 1 394 ? 145.39100 358.99300 30.24400  1.000 51.91797  ? 429 ARG F CG  1 
ATOM   2806 C CD  . ARG A 1 394 ? 145.20400 357.52900 30.51000  1.000 52.69609  ? 429 ARG F CD  1 
ATOM   2807 N NE  . ARG A 1 394 ? 146.43100 356.98600 31.06200  1.000 53.87405  ? 429 ARG F NE  1 
ATOM   2808 C CZ  . ARG A 1 394 ? 146.53400 355.77500 31.58200  1.000 59.14962  ? 429 ARG F CZ  1 
ATOM   2809 N NH1 . ARG A 1 394 ? 145.49200 354.95500 31.62800  1.000 58.69774  ? 429 ARG F NH1 1 
ATOM   2810 N NH2 . ARG A 1 394 ? 147.70800 355.37900 32.07000  1.000 57.54129  ? 429 ARG F NH2 1 
ATOM   2811 N N   . GLY A 1 395 ? 147.96400 360.71800 26.65000  1.000 40.66232  ? 430 GLY F N   1 
ATOM   2812 C CA  . GLY A 1 395 ? 148.84300 361.80500 26.27400  1.000 38.25106  ? 430 GLY F CA  1 
ATOM   2813 C C   . GLY A 1 395 ? 150.10100 361.84100 27.11100  1.000 36.99387  ? 430 GLY F C   1 
ATOM   2814 O O   . GLY A 1 395 ? 150.50100 360.80400 27.64000  1.000 38.51497  ? 430 GLY F O   1 
ATOM   2815 N N   . ILE A 1 396 ? 150.71200 363.01300 27.28400  1.000 32.29365  ? 431 ILE F N   1 
ATOM   2816 C CA  . ILE A 1 396 ? 151.95300 363.10900 28.04800  1.000 30.76138  ? 431 ILE F CA  1 
ATOM   2817 C C   . ILE A 1 396 ? 151.71400 362.84100 29.52900  1.000 31.13281  ? 431 ILE F C   1 
ATOM   2818 O O   . ILE A 1 396 ? 150.87500 363.48700 30.16500  1.000 34.57080  ? 431 ILE F O   1 
ATOM   2819 C CB  . ILE A 1 396 ? 152.61700 364.47200 27.85800  1.000 31.57256  ? 431 ILE F CB  1 
ATOM   2820 C CG1 . ILE A 1 396 ? 153.14500 364.62600 26.43500  1.000 29.75632  ? 431 ILE F CG1 1 
ATOM   2821 C CG2 . ILE A 1 396 ? 153.75500 364.60300 28.84600  1.000 27.95805  ? 431 ILE F CG2 1 
ATOM   2822 C CD1 . ILE A 1 396 ? 153.71300 366.03300 26.14800  1.000 27.25594  ? 431 ILE F CD1 1 
ATOM   2823 N N   . ILE A 1 397 ? 152.35200 361.80600 30.05800  1.000 29.68680  ? 432 ILE F N   1 
ATOM   2824 C CA  . ILE A 1 397 ? 152.25500 361.48200 31.47300  1.000 31.99908  ? 432 ILE F CA  1 
ATOM   2825 C C   . ILE A 1 397 ? 153.54500 361.78100 32.24000  1.000 29.85476  ? 432 ILE F C   1 
ATOM   2826 O O   . ILE A 1 397 ? 153.49000 361.92700 33.47900  1.000 32.17842  ? 432 ILE F O   1 
ATOM   2827 C CB  . ILE A 1 397 ? 151.74900 360.04300 31.72500  1.000 34.33886  ? 432 ILE F CB  1 
ATOM   2828 C CG1 . ILE A 1 397 ? 152.59300 358.99100 31.02800  1.000 36.83769  ? 432 ILE F CG1 1 
ATOM   2829 C CG2 . ILE A 1 397 ? 150.28100 359.90600 31.31200  1.000 38.68349  ? 432 ILE F CG2 1 
ATOM   2830 C CD1 . ILE A 1 397 ? 152.68300 357.70400 31.82400  1.000 38.33680  ? 432 ILE F CD1 1 
ATOM   2831 N N   . LYS A 1 398 ? 154.66500 362.03000 31.55100  1.000 28.51020  ? 433 LYS F N   1 
ATOM   2832 C CA  . LYS A 1 398 ? 155.89100 362.39300 32.26900  1.000 28.22504  ? 433 LYS F CA  1 
ATOM   2833 C C   . LYS A 1 398 ? 156.81400 363.25300 31.42900  1.000 25.65986  ? 433 LYS F C   1 
ATOM   2834 O O   . LYS A 1 398 ? 156.94800 363.01900 30.23300  1.000 26.47034  ? 433 LYS F O   1 
ATOM   2835 C CB  . LYS A 1 398 ? 156.69100 361.17100 32.70000  1.000 24.22774  ? 433 LYS F CB  1 
ATOM   2836 C CG  . LYS A 1 398 ? 157.96900 361.56600 33.43200  1.000 29.05646  ? 433 LYS F CG  1 
ATOM   2837 C CD  . LYS A 1 398 ? 158.72700 360.41300 34.16100  1.000 25.79114  ? 433 LYS F CD  1 
ATOM   2838 C CE  . LYS A 1 398 ? 159.86700 361.01400 34.99300  1.000 28.09725  ? 433 LYS F CE  1 
ATOM   2839 N NZ  . LYS A 1 398 ? 160.55600 359.99000 35.81100  1.000 38.61817  ? 433 LYS F NZ  1 
ATOM   2840 N N   . THR A 1 399 ? 157.30700 364.33700 32.01600  1.000 23.94458  ? 434 THR F N   1 
ATOM   2841 C CA  . THR A 1 399 ? 158.30400 365.17600 31.37500  1.000 24.58346  ? 434 THR F CA  1 
ATOM   2842 C C   . THR A 1 399 ? 159.62400 365.02600 32.11400  1.000 25.73152  ? 434 THR F C   1 
ATOM   2843 O O   . THR A 1 399 ? 159.70000 365.29200 33.31100  1.000 29.56693  ? 434 THR F O   1 
ATOM   2844 C CB  . THR A 1 399 ? 157.86600 366.63400 31.33600  1.000 24.92179  ? 434 THR F CB  1 
ATOM   2845 O OG1 . THR A 1 399 ? 156.59800 366.69500 30.69600  1.000 26.45088  ? 434 THR F OG1 1 
ATOM   2846 C CG2 . THR A 1 399 ? 158.86800 367.48200 30.54200  1.000 24.04768  ? 434 THR F CG2 1 
ATOM   2847 N N   . PHE A 1 400 ? 160.65700 364.60000 31.39700  1.000 26.86266  ? 435 PHE F N   1 
ATOM   2848 C CA  . PHE A 1 400 ? 161.96800 364.37600 31.99400  1.000 27.29319  ? 435 PHE F CA  1 
ATOM   2849 C C   . PHE A 1 400 ? 162.68800 365.70100 32.16200  1.000 28.22241  ? 435 PHE F C   1 
ATOM   2850 O O   . PHE A 1 400 ? 162.54400 366.61700 31.33400  1.000 25.94634  ? 435 PHE F O   1 
ATOM   2851 C CB  . PHE A 1 400 ? 162.83300 363.43000 31.15400  1.000 24.61159  ? 435 PHE F CB  1 
ATOM   2852 C CG  . PHE A 1 400 ? 162.22700 362.08100 30.94200  1.000 27.45984  ? 435 PHE F CG  1 
ATOM   2853 C CD1 . PHE A 1 400 ? 161.36500 361.83700 29.89000  1.000 23.92624  ? 435 PHE F CD1 1 
ATOM   2854 C CD2 . PHE A 1 400 ? 162.52800 361.03900 31.80500  1.000 29.44643  ? 435 PHE F CD2 1 
ATOM   2855 C CE1 . PHE A 1 400 ? 160.80300 360.60400 29.71700  1.000 21.05790  ? 435 PHE F CE1 1 
ATOM   2856 C CE2 . PHE A 1 400 ? 161.97000 359.78500 31.61300  1.000 27.46867  ? 435 PHE F CE2 1 
ATOM   2857 C CZ  . PHE A 1 400 ? 161.10300 359.57600 30.57000  1.000 25.47482  ? 435 PHE F CZ  1 
ATOM   2858 N N   . SER A 1 401 ? 163.41300 365.83400 33.27500  1.000 32.08826  ? 436 SER F N   1 
ATOM   2859 C CA  . SER A 1 401 ? 164.23200 367.03400 33.39700  1.000 37.43388  ? 436 SER F CA  1 
ATOM   2860 C C   . SER A 1 401 ? 165.64800 366.78100 32.86400  1.000 33.55174  ? 436 SER F C   1 
ATOM   2861 O O   . SER A 1 401 ? 166.01500 365.67800 32.46900  1.000 30.51384  ? 436 SER F O   1 
ATOM   2862 C CB  . SER A 1 401 ? 164.30600 367.50800 34.85800  1.000 33.26366  ? 436 SER F CB  1 
ATOM   2863 O OG  . SER A 1 401 ? 163.11200 368.13300 35.30800  1.000 35.58905  ? 436 SER F OG  1 
ATOM   2864 N N   . ASN A 1 402 ? 166.48500 367.79700 32.96100  1.000 31.43060  ? 437 ASN F N   1 
ATOM   2865 C CA  . ASN A 1 402 ? 167.85300 367.68200 32.50300  1.000 31.12200  ? 437 ASN F CA  1 
ATOM   2866 C C   . ASN A 1 402 ? 168.57000 366.69400 33.40300  1.000 32.31341  ? 437 ASN F C   1 
ATOM   2867 O O   . ASN A 1 402 ? 168.45100 366.75200 34.63300  1.000 30.65711  ? 437 ASN F O   1 
ATOM   2868 C CB  . ASN A 1 402 ? 168.55000 369.04000 32.52600  1.000 35.02021  ? 437 ASN F CB  1 
ATOM   2869 C CG  . ASN A 1 402 ? 168.35400 369.82600 31.25700  1.000 36.98328  ? 437 ASN F CG  1 
ATOM   2870 O OD1 . ASN A 1 402 ? 167.52900 369.48700 30.40300  1.000 39.20720  ? 437 ASN F OD1 1 
ATOM   2871 N ND2 . ASN A 1 402 ? 169.08300 370.93100 31.15000  1.000 39.40133  ? 437 ASN F ND2 1 
ATOM   2872 N N   . GLY A 1 403 ? 169.24200 365.73300 32.78600  1.000 31.65271  ? 438 GLY F N   1 
ATOM   2873 C CA  . GLY A 1 403 ? 169.90600 364.69100 33.53200  1.000 32.10112  ? 438 GLY F CA  1 
ATOM   2874 C C   . GLY A 1 403 ? 169.53600 363.36600 32.95400  1.000 28.34392  ? 438 GLY F C   1 
ATOM   2875 O O   . GLY A 1 403 ? 169.11700 363.26600 31.79300  1.000 29.25374  ? 438 GLY F O   1 
ATOM   2876 N N   . CYS A 1 404 ? 169.82300 362.30800 33.70200  1.000 26.49566  ? 439 CYS F N   1 
ATOM   2877 C CA  . CYS A 1 404 ? 169.50200 360.96300 33.25300  1.000 27.46237  ? 439 CYS F CA  1 
ATOM   2878 C C   . CYS A 1 404 ? 168.34800 360.44500 34.10200  1.000 27.43655  ? 439 CYS F C   1 
ATOM   2879 O O   . CYS A 1 404 ? 168.40600 360.51500 35.33100  1.000 27.01523  ? 439 CYS F O   1 
ATOM   2880 C CB  . CYS A 1 404 ? 170.73400 360.05900 33.33700  1.000 27.90700  ? 439 CYS F CB  1 
ATOM   2881 S SG  . CYS A 1 404 ? 170.45300 358.29200 32.94900  1.000 34.30901  ? 439 CYS F SG  1 
ATOM   2882 N N   . ASP A 1 405 ? 167.31000 359.91300 33.45600  1.000 23.99947  ? 440 ASP F N   1 
ATOM   2883 C CA  . ASP A 1 405 ? 166.16600 359.43500 34.19900  1.000 23.16291  ? 440 ASP F CA  1 
ATOM   2884 C C   . ASP A 1 405 ? 165.65500 358.13100 33.58800  1.000 25.71373  ? 440 ASP F C   1 
ATOM   2885 O O   . ASP A 1 405 ? 166.15700 357.65600 32.55900  1.000 26.58358  ? 440 ASP F O   1 
ATOM   2886 C CB  . ASP A 1 405 ? 165.06700 360.48800 34.18000  1.000 26.84207  ? 440 ASP F CB  1 
ATOM   2887 C CG  . ASP A 1 405 ? 164.20900 360.44300 35.38500  1.000 29.46707  ? 440 ASP F CG  1 
ATOM   2888 O OD1 . ASP A 1 405 ? 164.22200 359.42300 36.10700  1.000 32.03137  ? 440 ASP F OD1 1 
ATOM   2889 O OD2 . ASP A 1 405 ? 163.44900 361.40500 35.56200  1.000 35.40493  ? 440 ASP F OD2 1 
ATOM   2890 N N   . TYR A 1 406 ? 164.57000 357.60700 34.16500  1.000 26.10263  ? 441 TYR F N   1 
ATOM   2891 C CA  . TYR A 1 406 ? 164.04100 356.31800 33.74300  1.000 26.47035  ? 441 TYR F CA  1 
ATOM   2892 C C   . TYR A 1 406 ? 162.55100 356.23600 33.96800  1.000 26.43207  ? 441 TYR F C   1 
ATOM   2893 O O   . TYR A 1 406 ? 162.02500 356.84400 34.89200  1.000 29.47492  ? 441 TYR F O   1 
ATOM   2894 C CB  . TYR A 1 406 ? 164.70000 355.19500 34.54000  1.000 25.18496  ? 441 TYR F CB  1 
ATOM   2895 C CG  . TYR A 1 406 ? 164.14500 353.81500 34.36000  1.000 26.40042  ? 441 TYR F CG  1 
ATOM   2896 C CD1 . TYR A 1 406 ? 163.09600 353.34400 35.14500  1.000 29.61870  ? 441 TYR F CD1 1 
ATOM   2897 C CD2 . TYR A 1 406 ? 164.70600 352.94400 33.43200  1.000 28.94513  ? 441 TYR F CD2 1 
ATOM   2898 C CE1 . TYR A 1 406 ? 162.60100 352.01400 34.98400  1.000 30.18254  ? 441 TYR F CE1 1 
ATOM   2899 C CE2 . TYR A 1 406 ? 164.24100 351.63400 33.28000  1.000 28.76429  ? 441 TYR F CE2 1 
ATOM   2900 C CZ  . TYR A 1 406 ? 163.20000 351.17200 34.05400  1.000 28.85548  ? 441 TYR F CZ  1 
ATOM   2901 O OH  . TYR A 1 406 ? 162.77600 349.88200 33.85100  1.000 31.51287  ? 441 TYR F OH  1 
ATOM   2902 N N   . VAL A 1 407 ? 161.87000 355.46700 33.14000  1.000 25.04660  ? 442 VAL F N   1 
ATOM   2903 C CA  . VAL A 1 407 ? 160.44600 355.30000 33.36200  1.000 27.57075  ? 442 VAL F CA  1 
ATOM   2904 C C   . VAL A 1 407 ? 160.13500 353.83600 33.09700  1.000 30.43439  ? 442 VAL F C   1 
ATOM   2905 O O   . VAL A 1 407 ? 160.71300 353.23300 32.18600  1.000 31.11529  ? 442 VAL F O   1 
ATOM   2906 C CB  . VAL A 1 407 ? 159.58800 356.22000 32.47200  1.000 23.33255  ? 442 VAL F CB  1 
ATOM   2907 C CG1 . VAL A 1 407 ? 159.72500 355.85800 31.02000  1.000 25.85856  ? 442 VAL F CG1 1 
ATOM   2908 C CG2 . VAL A 1 407 ? 158.18500 356.20700 32.92900  1.000 24.20515  ? 442 VAL F CG2 1 
ATOM   2909 N N   . SER A 1 408 ? 159.25000 353.25300 33.90600  1.000 32.24786  ? 443 SER F N   1 
ATOM   2910 C CA  . SER A 1 408 ? 158.85200 351.86600 33.70200  1.000 31.88719  ? 443 SER F CA  1 
ATOM   2911 C C   . SER A 1 408 ? 157.83000 351.82800 32.57800  1.000 34.13892  ? 443 SER F C   1 
ATOM   2912 O O   . SER A 1 408 ? 157.22800 352.84600 32.22200  1.000 38.15024  ? 443 SER F O   1 
ATOM   2913 C CB  . SER A 1 408 ? 158.31700 351.19700 34.98000  1.000 35.91842  ? 443 SER F CB  1 
ATOM   2914 O OG  . SER A 1 408 ? 157.12600 351.77300 35.47900  1.000 44.77809  ? 443 SER F OG  1 
ATOM   2915 N N   . ASN A 1 409 ? 157.61800 350.63900 32.02700  1.000 34.71768  ? 444 ASN F N   1 
ATOM   2916 C CA  . ASN A 1 409 ? 156.62800 350.48900 30.96600  1.000 36.80014  ? 444 ASN F CA  1 
ATOM   2917 C C   . ASN A 1 409 ? 155.20900 350.37700 31.49500  1.000 34.70122  ? 444 ASN F C   1 
ATOM   2918 O O   . ASN A 1 409 ? 154.28000 350.27500 30.69100  1.000 34.16252  ? 444 ASN F O   1 
ATOM   2919 C CB  . ASN A 1 409 ? 156.89500 349.26000 30.08300  1.000 37.58905  ? 444 ASN F CB  1 
ATOM   2920 C CG  . ASN A 1 409 ? 156.89500 347.94900 30.84000  1.000 34.88882  ? 444 ASN F CG  1 
ATOM   2921 O OD1 . ASN A 1 409 ? 156.73700 347.88700 32.06800  1.000 37.75684  ? 444 ASN F OD1 1 
ATOM   2922 N ND2 . ASN A 1 409 ? 157.06400 346.87500 30.08800  1.000 34.31205  ? 444 ASN F ND2 1 
ATOM   2923 N N   . LYS A 1 410 ? 155.03200 350.31200 32.80500  1.000 37.72736  ? 445 LYS F N   1 
ATOM   2924 C CA  . LYS A 1 410 ? 153.71600 350.19500 33.41700  1.000 42.64359  ? 445 LYS F CA  1 
ATOM   2925 C C   . LYS A 1 410 ? 153.00900 351.54700 33.28700  1.000 38.38970  ? 445 LYS F C   1 
ATOM   2926 O O   . LYS A 1 410 ? 153.30700 352.50100 34.01200  1.000 37.37398  ? 445 LYS F O   1 
ATOM   2927 C CB  . LYS A 1 410 ? 153.94000 349.75000 34.86000  1.000 40.85619  ? 445 LYS F CB  1 
ATOM   2928 C CG  . LYS A 1 410 ? 153.58400 348.27400 35.05500  1.000 48.62569  ? 445 LYS F CG  1 
ATOM   2929 C CD  . LYS A 1 410 ? 154.35700 347.58900 36.18600  1.000 48.46521  ? 445 LYS F CD  1 
ATOM   2930 C CE  . LYS A 1 410 ? 153.97000 346.11100 36.24500  1.000 53.63975  ? 445 LYS F CE  1 
ATOM   2931 N NZ  . LYS A 1 410 ? 154.64600 345.32900 37.35000  1.000 57.63709  ? 445 LYS F NZ  1 
ATOM   2932 N N   . GLY A 1 411 ? 152.10200 351.63200 32.30300  1.000 35.64417  ? 446 GLY F N   1 
ATOM   2933 C CA  . GLY A 1 411 ? 151.33400 352.82800 31.98900  1.000 41.13398  ? 446 GLY F CA  1 
ATOM   2934 C C   . GLY A 1 411 ? 151.90200 353.69700 30.87600  1.000 42.57768  ? 446 GLY F C   1 
ATOM   2935 O O   . GLY A 1 411 ? 151.22700 354.63800 30.43600  1.000 50.61134  ? 446 GLY F O   1 
ATOM   2936 N N   . VAL A 1 412 ? 153.10000 353.39000 30.39900  1.000 37.44456  ? 447 VAL F N   1 
ATOM   2937 C CA  . VAL A 1 412 ? 153.79000 354.12300 29.35000  1.000 34.77113  ? 447 VAL F CA  1 
ATOM   2938 C C   . VAL A 1 412 ? 153.77200 353.31100 28.06900  1.000 37.22301  ? 447 VAL F C   1 
ATOM   2939 O O   . VAL A 1 412 ? 154.00800 352.10000 28.10000  1.000 40.78549  ? 447 VAL F O   1 
ATOM   2940 C CB  . VAL A 1 412 ? 155.24200 354.43000 29.73300  1.000 33.93514  ? 447 VAL F CB  1 
ATOM   2941 C CG1 . VAL A 1 412 ? 155.95000 355.09500 28.56600  1.000 31.36707  ? 447 VAL F CG1 1 
ATOM   2942 C CG2 . VAL A 1 412 ? 155.25600 355.33600 30.92100  1.000 31.83673  ? 447 VAL F CG2 1 
ATOM   2943 N N   . ASP A 1 413 ? 153.45800 353.96100 26.95300  1.000 37.65058  ? 448 ASP F N   1 
ATOM   2944 C CA  . ASP A 1 413 ? 153.49100 353.30300 25.65800  1.000 37.20965  ? 448 ASP F CA  1 
ATOM   2945 C C   . ASP A 1 413 ? 154.66600 353.81300 24.83300  1.000 35.25677  ? 448 ASP F C   1 
ATOM   2946 O O   . ASP A 1 413 ? 155.45500 353.02100 24.30200  1.000 34.48253  ? 448 ASP F O   1 
ATOM   2947 C CB  . ASP A 1 413 ? 152.17400 353.49500 24.89000  1.000 43.92639  ? 448 ASP F CB  1 
ATOM   2948 C CG  . ASP A 1 413 ? 150.98400 352.81700 25.57700  1.000 52.72426  ? 448 ASP F CG  1 
ATOM   2949 O OD1 . ASP A 1 413 ? 151.18600 351.75800 26.23400  1.000 50.67907  ? 448 ASP F OD1 1 
ATOM   2950 O OD2 . ASP A 1 413 ? 149.84200 353.33300 25.43000  1.000 51.35551  ? 448 ASP F OD2 1 
ATOM   2951 N N   . THR A 1 414 ? 154.86100 355.13000 24.79200  1.000 32.80220  ? 449 THR F N   1 
ATOM   2952 C CA  . THR A 1 414 ? 155.92800 355.71700 23.99600  1.000 32.93213  ? 449 THR F CA  1 
ATOM   2953 C C   . THR A 1 414 ? 156.73600 356.73000 24.80400  1.000 32.61645  ? 449 THR F C   1 
ATOM   2954 O O   . THR A 1 414 ? 156.33300 357.20200 25.87300  1.000 34.56130  ? 449 THR F O   1 
ATOM   2955 C CB  . THR A 1 414 ? 155.40800 356.40100 22.72800  1.000 32.68795  ? 449 THR F CB  1 
ATOM   2956 O OG1 . THR A 1 414 ? 154.50500 357.44400 23.09100  1.000 36.93678  ? 449 THR F OG1 1 
ATOM   2957 C CG2 . THR A 1 414 ? 154.70100 355.40800 21.85400  1.000 31.83369  ? 449 THR F CG2 1 
ATOM   2958 N N   . VAL A 1 415 ? 157.92900 356.98300 24.29400  1.000 26.68303  ? 450 VAL F N   1 
ATOM   2959 C CA  . VAL A 1 415 ? 158.85300 357.96600 24.81300  1.000 25.94624  ? 450 VAL F CA  1 
ATOM   2960 C C   . VAL A 1 415 ? 159.35700 358.79500 23.63600  1.000 26.61286  ? 450 VAL F C   1 
ATOM   2961 O O   . VAL A 1 415 ? 159.74400 358.23600 22.61200  1.000 31.24121  ? 450 VAL F O   1 
ATOM   2962 C CB  . VAL A 1 415 ? 160.01600 357.27200 25.56500  1.000 25.56946  ? 450 VAL F CB  1 
ATOM   2963 C CG1 . VAL A 1 415 ? 161.17700 358.20000 25.80600  1.000 25.71903  ? 450 VAL F CG1 1 
ATOM   2964 C CG2 . VAL A 1 415 ? 159.55100 356.76800 26.90200  1.000 23.72745  ? 450 VAL F CG2 1 
ATOM   2965 N N   . SER A 1 416 ? 159.25200 360.11600 23.72100  1.000 23.89197  ? 451 SER F N   1 
ATOM   2966 C CA  . SER A 1 416 ? 159.69900 361.01200 22.65800  1.000 22.19545  ? 451 SER F CA  1 
ATOM   2967 C C   . SER A 1 416 ? 160.91000 361.77800 23.17400  1.000 24.14691  ? 451 SER F C   1 
ATOM   2968 O O   . SER A 1 416 ? 160.92800 362.18900 24.33000  1.000 25.20277  ? 451 SER F O   1 
ATOM   2969 C CB  . SER A 1 416 ? 158.63800 362.00500 22.19900  1.000 25.99580  ? 451 SER F CB  1 
ATOM   2970 O OG  . SER A 1 416 ? 157.53500 361.38200 21.58800  1.000 35.61107  ? 451 SER F OG  1 
ATOM   2971 N N   . VAL A 1 417 ? 161.98100 361.80000 22.38900  1.000 25.16300  ? 452 VAL F N   1 
ATOM   2972 C CA  . VAL A 1 417 ? 163.19500 362.55800 22.67300  1.000 21.56144  ? 452 VAL F CA  1 
ATOM   2973 C C   . VAL A 1 417 ? 163.51100 363.37300 21.42300  1.000 26.88520  ? 452 VAL F C   1 
ATOM   2974 O O   . VAL A 1 417 ? 163.74800 362.79500 20.34600  1.000 25.88011  ? 452 VAL F O   1 
ATOM   2975 C CB  . VAL A 1 417 ? 164.37900 361.66500 23.08200  1.000 22.55411  ? 452 VAL F CB  1 
ATOM   2976 C CG1 . VAL A 1 417 ? 165.67000 362.46300 23.19000  1.000 17.95836  ? 452 VAL F CG1 1 
ATOM   2977 C CG2 . VAL A 1 417 ? 164.08000 360.99500 24.40500  1.000 25.51323  ? 452 VAL F CG2 1 
ATOM   2978 N N   . GLY A 1 418 ? 163.33800 364.69400 21.51100  1.000 27.31165  ? 453 GLY F N   1 
ATOM   2979 C CA  . GLY A 1 418 ? 163.53000 365.53700 20.33700  1.000 27.52830  ? 453 GLY F CA  1 
ATOM   2980 C C   . GLY A 1 418 ? 162.47800 365.22500 19.30000  1.000 29.43451  ? 453 GLY F C   1 
ATOM   2981 O O   . GLY A 1 418 ? 161.29200 365.11200 19.62300  1.000 35.45225  ? 453 GLY F O   1 
ATOM   2982 N N   . ASN A 1 419 ? 162.90300 364.97800 18.06000  1.000 25.44238  ? 454 ASN F N   1 
ATOM   2983 C CA  . ASN A 1 419 ? 161.96900 364.61800 17.00500  1.000 26.34468  ? 454 ASN F CA  1 
ATOM   2984 C C   . ASN A 1 419 ? 161.84300 363.11500 16.80900  1.000 27.69439  ? 454 ASN F C   1 
ATOM   2985 O O   . ASN A 1 419 ? 161.26600 362.68500 15.80900  1.000 30.83643  ? 454 ASN F O   1 
ATOM   2986 C CB  . ASN A 1 419 ? 162.37100 365.25200 15.67100  1.000 25.61098  ? 454 ASN F CB  1 
ATOM   2987 C CG  . ASN A 1 419 ? 162.40200 366.76000 15.72400  1.000 29.43803  ? 454 ASN F CG  1 
ATOM   2988 O OD1 . ASN A 1 419 ? 161.68900 367.35600 16.53400  1.000 31.44598  ? 454 ASN F OD1 1 
ATOM   2989 N ND2 . ASN A 1 419 ? 163.14900 367.39800 14.79200  1.000 25.44536  ? 454 ASN F ND2 1 
ATOM   2990 N N   . THR A 1 420 ? 162.28600 362.31200 17.77000  1.000 27.95821  ? 455 THR F N   1 
ATOM   2991 C CA  . THR A 1 420 ? 162.26500 360.85700 17.65700  1.000 29.71841  ? 455 THR F CA  1 
ATOM   2992 C C   . THR A 1 420 ? 161.29900 360.21200 18.64400  1.000 30.75658  ? 455 THR F C   1 
ATOM   2993 O O   . THR A 1 420 ? 161.26800 360.58300 19.82300  1.000 31.50020  ? 455 THR F O   1 
ATOM   2994 C CB  . THR A 1 420 ? 163.67500 360.29400 17.86200  1.000 32.28939  ? 455 THR F CB  1 
ATOM   2995 O OG1 . THR A 1 420 ? 164.55700 360.87200 16.88800  1.000 35.02978  ? 455 THR F OG1 1 
ATOM   2996 C CG2 . THR A 1 420 ? 163.69800 358.75600 17.75100  1.000 31.80046  ? 455 THR F CG2 1 
ATOM   2997 N N   . LEU A 1 421 ? 160.49800 359.26300 18.16500  1.000 29.61210  ? 456 LEU F N   1 
ATOM   2998 C CA  . LEU A 1 421 ? 159.55500 358.56800 19.02500  1.000 31.25941  ? 456 LEU F CA  1 
ATOM   2999 C C   . LEU A 1 421 ? 159.93100 357.09400 19.07700  1.000 31.55687  ? 456 LEU F C   1 
ATOM   3000 O O   . LEU A 1 421 ? 160.00300 356.42600 18.04100  1.000 34.34694  ? 456 LEU F O   1 
ATOM   3001 C CB  . LEU A 1 421 ? 158.11600 358.75200 18.54300  1.000 31.52224  ? 456 LEU F CB  1 
ATOM   3002 C CG  . LEU A 1 421 ? 157.10300 358.07700 19.46900  1.000 30.20176  ? 456 LEU F CG  1 
ATOM   3003 C CD1 . LEU A 1 421 ? 155.91700 358.93300 19.70200  1.000 36.77848  ? 456 LEU F CD1 1 
ATOM   3004 C CD2 . LEU A 1 421 ? 156.64200 356.83400 18.77900  1.000 31.82480  ? 456 LEU F CD2 1 
ATOM   3005 N N   . TYR A 1 422 ? 160.17900 356.61400 20.29500  1.000 29.02994  ? 457 TYR F N   1 
ATOM   3006 C CA  . TYR A 1 422 ? 160.50500 355.24400 20.63800  1.000 29.49966  ? 457 TYR F CA  1 
ATOM   3007 C C   . TYR A 1 422 ? 159.29000 354.56100 21.24000  1.000 34.69020  ? 457 TYR F C   1 
ATOM   3008 O O   . TYR A 1 422 ? 158.56200 355.15800 22.03700  1.000 33.41973  ? 457 TYR F O   1 
ATOM   3009 C CB  . TYR A 1 422 ? 161.61500 355.20500 21.67600  1.000 29.23671  ? 457 TYR F CB  1 
ATOM   3010 C CG  . TYR A 1 422 ? 162.82700 355.99600 21.32700  1.000 36.40325  ? 457 TYR F CG  1 
ATOM   3011 C CD1 . TYR A 1 422 ? 162.89400 357.34700 21.64400  1.000 32.31114  ? 457 TYR F CD1 1 
ATOM   3012 C CD2 . TYR A 1 422 ? 163.94000 355.40000 20.73100  1.000 41.51626  ? 457 TYR F CD2 1 
ATOM   3013 C CE1 . TYR A 1 422 ? 164.02800 358.09900 21.34500  1.000 36.49673  ? 457 TYR F CE1 1 
ATOM   3014 C CE2 . TYR A 1 422 ? 165.09000 356.15000 20.42700  1.000 43.08327  ? 457 TYR F CE2 1 
ATOM   3015 C CZ  . TYR A 1 422 ? 165.12600 357.50000 20.73500  1.000 41.34456  ? 457 TYR F CZ  1 
ATOM   3016 O OH  . TYR A 1 422 ? 166.24800 358.26400 20.45200  1.000 42.88825  ? 457 TYR F OH  1 
ATOM   3017 N N   . TYR A 1 423 ? 159.12500 353.28400 20.93200  1.000 39.39329  ? 458 TYR F N   1 
ATOM   3018 C CA  . TYR A 1 423 ? 158.09000 352.47800 21.55500  1.000 32.92218  ? 458 TYR F CA  1 
ATOM   3019 C C   . TYR A 1 423 ? 158.69800 351.65000 22.68300  1.000 30.14808  ? 458 TYR F C   1 
ATOM   3020 O O   . TYR A 1 423 ? 159.77900 351.07700 22.54100  1.000 28.96058  ? 458 TYR F O   1 
ATOM   3021 C CB  . TYR A 1 423 ? 157.40800 351.59400 20.51900  1.000 33.41129  ? 458 TYR F CB  1 
ATOM   3022 C CG  . TYR A 1 423 ? 156.63900 352.37400 19.46500  1.000 37.42132  ? 458 TYR F CG  1 
ATOM   3023 C CD1 . TYR A 1 423 ? 157.28100 352.89700 18.33000  1.000 36.47507  ? 458 TYR F CD1 1 
ATOM   3024 C CD2 . TYR A 1 423 ? 155.27200 352.62600 19.61900  1.000 39.12493  ? 458 TYR F CD2 1 
ATOM   3025 C CE1 . TYR A 1 423 ? 156.56000 353.61900 17.34800  1.000 35.29621  ? 458 TYR F CE1 1 
ATOM   3026 C CE2 . TYR A 1 423 ? 154.54200 353.35100 18.65100  1.000 36.17582  ? 458 TYR F CE2 1 
ATOM   3027 C CZ  . TYR A 1 423 ? 155.19200 353.84400 17.52600  1.000 37.71703  ? 458 TYR F CZ  1 
ATOM   3028 O OH  . TYR A 1 423 ? 154.46300 354.54300 16.58500  1.000 40.47257  ? 458 TYR F OH  1 
ATOM   3029 N N   . VAL A 1 424 ? 158.02600 351.63900 23.79900  1.000 29.17592  ? 459 VAL F N   1 
ATOM   3030 C CA  . VAL A 1 424 ? 158.38300 350.84200 24.96500  1.000 31.18768  ? 459 VAL F CA  1 
ATOM   3031 C C   . VAL A 1 424 ? 157.86600 349.42000 24.84100  1.000 36.77548  ? 459 VAL F C   1 
ATOM   3032 O O   . VAL A 1 424 ? 156.74900 349.18200 24.35500  1.000 37.86247  ? 459 VAL F O   1 
ATOM   3033 C CB  . VAL A 1 424 ? 157.85700 351.50300 26.24500  1.000 31.44273  ? 459 VAL F CB  1 
ATOM   3034 C CG1 . VAL A 1 424 ? 158.27600 350.73400 27.42200  1.000 30.36889  ? 459 VAL F CG1 1 
ATOM   3035 C CG2 . VAL A 1 424 ? 158.50500 352.83500 26.36300  1.000 32.15381  ? 459 VAL F CG2 1 
ATOM   3036 N N   . ASN A 1 425 ? 158.72500 348.46700 25.20600  1.000 39.40373  ? 460 ASN F N   1 
ATOM   3037 C CA  . ASN A 1 425 ? 158.35600 347.05900 25.19300  1.000 40.04524  ? 460 ASN F CA  1 
ATOM   3038 C C   . ASN A 1 425 ? 157.31000 346.78700 26.27000  1.000 38.46329  ? 460 ASN F C   1 
ATOM   3039 O O   . ASN A 1 425 ? 157.51900 347.10600 27.44100  1.000 34.75619  ? 460 ASN F O   1 
ATOM   3040 C CB  . ASN A 1 425 ? 159.61600 346.23000 25.44800  1.000 41.01350  ? 460 ASN F CB  1 
ATOM   3041 C CG  . ASN A 1 425 ? 159.38500 344.73900 25.39400  1.000 44.93388  ? 460 ASN F CG  1 
ATOM   3042 O OD1 . ASN A 1 425 ? 158.41500 344.24300 24.81600  1.000 52.53523  ? 460 ASN F OD1 1 
ATOM   3043 N ND2 . ASN A 1 425 ? 160.28900 344.00600 26.02200  1.000 45.82512  ? 460 ASN F ND2 1 
ATOM   3044 N N   . LYS A 1 426 ? 156.20200 346.14200 25.88200  1.000 41.83603  ? 461 LYS F N   1 
ATOM   3045 C CA  . LYS A 1 426 ? 155.07800 345.86400 26.77500  1.000 44.62599  ? 461 LYS F CA  1 
ATOM   3046 C C   . LYS A 1 426 ? 155.19800 344.51000 27.49600  1.000 46.79101  ? 461 LYS F C   1 
ATOM   3047 O O   . LYS A 1 426 ? 154.18800 343.97400 27.98300  1.000 46.92249  ? 461 LYS F O   1 
ATOM   3048 C CB  . LYS A 1 426 ? 153.75700 345.96600 26.00300  1.000 38.32695  ? 461 LYS F CB  1 
ATOM   3049 C CG  . LYS A 1 426 ? 153.53000 347.27300 25.26600  1.000 34.27317  ? 461 LYS F CG  1 
ATOM   3050 C CD  . LYS A 1 426 ? 153.63800 348.49500 26.19300  1.000 39.47852  ? 461 LYS F CD  1 
ATOM   3051 C CE  . LYS A 1 426 ? 152.53600 348.49800 27.26600  1.000 45.10751  ? 461 LYS F CE  1 
ATOM   3052 N NZ  . LYS A 1 426 ? 152.57800 349.63400 28.25600  1.000 42.78617  ? 461 LYS F NZ  1 
ATOM   3053 N N   . GLN A 1 427 ? 156.42200 344.05400 27.74500  1.000 43.89557  ? 462 GLN F N   1 
ATOM   3054 C CA  . GLN A 1 427 ? 156.68400 342.78800 28.42100  1.000 42.86500  ? 462 GLN F CA  1 
ATOM   3055 C C   . GLN A 1 427 ? 156.32700 342.89200 29.90100  1.000 45.71218  ? 462 GLN F C   1 
ATOM   3056 O O   . GLN A 1 427 ? 156.58300 343.90900 30.55000  1.000 46.19768  ? 462 GLN F O   1 
ATOM   3057 C CB  . GLN A 1 427 ? 158.17800 342.47900 28.30000  1.000 46.15875  ? 462 GLN F CB  1 
ATOM   3058 C CG  . GLN A 1 427 ? 158.67700 341.21100 28.96300  1.000 48.40134  ? 462 GLN F CG  1 
ATOM   3059 C CD  . GLN A 1 427 ? 159.60600 340.43800 28.06700  1.000 59.33801  ? 462 GLN F CD  1 
ATOM   3060 O OE1 . GLN A 1 427 ? 160.56100 341.01000 27.51500  1.000 60.23076  ? 462 GLN F OE1 1 
ATOM   3061 N NE2 . GLN A 1 427 ? 159.36100 339.13000 27.92700  1.000 61.25106  ? 462 GLN F NE2 1 
ATOM   3062 N N   . GLU A 1 428 ? 155.76000 341.82900 30.45900  1.000 44.53599  ? 463 GLU F N   1 
ATOM   3063 C CA  . GLU A 1 428 ? 155.39100 341.88300 31.86600  1.000 47.51645  ? 463 GLU F CA  1 
ATOM   3064 C C   . GLU A 1 428 ? 156.61300 341.69700 32.76600  1.000 45.50404  ? 463 GLU F C   1 
ATOM   3065 O O   . GLU A 1 428 ? 157.49000 340.87400 32.48600  1.000 47.70064  ? 463 GLU F O   1 
ATOM   3066 C CB  . GLU A 1 428 ? 154.36000 340.79900 32.17100  1.000 54.59008  ? 463 GLU F CB  1 
ATOM   3067 C CG  . GLU A 1 428 ? 152.99500 341.11900 31.60300  1.000 68.87833  ? 463 GLU F CG  1 
ATOM   3068 C CD  . GLU A 1 428 ? 152.17600 341.94500 32.56800  1.000 80.58689  ? 463 GLU F CD  1 
ATOM   3069 O OE1 . GLU A 1 428 ? 152.68600 343.01600 32.99000  1.000 74.72105  ? 463 GLU F OE1 1 
ATOM   3070 O OE2 . GLU A 1 428 ? 151.03000 341.54200 32.88600  1.000 92.00984  ? 463 GLU F OE2 1 
ATOM   3071 N N   . GLY A 1 429 ? 156.69500 342.51800 33.81100  1.000 40.85665  ? 464 GLY F N   1 
ATOM   3072 C CA  . GLY A 1 429 ? 157.80200 342.46200 34.74800  1.000 36.57886  ? 464 GLY F CA  1 
ATOM   3073 C C   . GLY A 1 429 ? 157.74700 343.62300 35.72000  1.000 40.39477  ? 464 GLY F C   1 
ATOM   3074 O O   . GLY A 1 429 ? 157.05000 344.62000 35.50100  1.000 45.15594  ? 464 GLY F O   1 
ATOM   3075 N N   . LYS A 1 430 ? 158.55000 343.50500 36.78200  1.000 41.18175  ? 465 LYS F N   1 
ATOM   3076 C CA  . LYS A 1 430 ? 158.70500 344.54300 37.79900  1.000 44.79312  ? 465 LYS F CA  1 
ATOM   3077 C C   . LYS A 1 430 ? 159.98700 345.35300 37.58800  1.000 44.71280  ? 465 LYS F C   1 
ATOM   3078 O O   . LYS A 1 430 ? 161.06000 344.79300 37.33300  1.000 43.20578  ? 465 LYS F O   1 
ATOM   3079 C CB  . LYS A 1 430 ? 158.70600 343.93100 39.21100  1.000 47.43787  ? 465 LYS F CB  1 
ATOM   3080 C CG  . LYS A 1 430 ? 157.43500 343.11900 39.54000  1.000 60.19568  ? 465 LYS F CG  1 
ATOM   3081 C CD  . LYS A 1 430 ? 157.44000 342.48600 40.94200  1.000 62.68709  ? 465 LYS F CD  1 
ATOM   3082 C CE  . LYS A 1 430 ? 156.01800 342.42300 41.55000  1.000 76.06018  ? 465 LYS F CE  1 
ATOM   3083 N NZ  . LYS A 1 430 ? 154.94000 343.10000 40.72900  1.000 77.16411  ? 465 LYS F NZ  1 
ATOM   3084 N N   . SER A 1 431 ? 159.86400 346.67900 37.70700  1.000 43.53453  ? 466 SER F N   1 
ATOM   3085 C CA  . SER A 1 431 ? 160.97800 347.61500 37.64600  1.000 34.25996  ? 466 SER F CA  1 
ATOM   3086 C C   . SER A 1 431 ? 161.23100 348.20300 39.02400  1.000 37.01721  ? 466 SER F C   1 
ATOM   3087 O O   . SER A 1 431 ? 160.29800 348.42000 39.80100  1.000 43.82107  ? 466 SER F O   1 
ATOM   3088 C CB  . SER A 1 431 ? 160.70300 348.76100 36.67600  1.000 36.62961  ? 466 SER F CB  1 
ATOM   3089 O OG  . SER A 1 431 ? 160.50000 348.30500 35.35700  1.000 39.09188  ? 466 SER F OG  1 
ATOM   3090 N N   . LEU A 1 432 ? 162.49600 348.49600 39.30100  1.000 31.09804  ? 467 LEU F N   1 
ATOM   3091 C CA  . LEU A 1 432 ? 162.93000 349.07300 40.56700  1.000 28.98454  ? 467 LEU F CA  1 
ATOM   3092 C C   . LEU A 1 432 ? 163.80100 350.28700 40.29000  1.000 30.54509  ? 467 LEU F C   1 
ATOM   3093 O O   . LEU A 1 432 ? 164.87500 350.16500 39.68600  1.000 32.60969  ? 467 LEU F O   1 
ATOM   3094 C CB  . LEU A 1 432 ? 163.69600 348.06100 41.42500  1.000 33.07061  ? 467 LEU F CB  1 
ATOM   3095 C CG  . LEU A 1 432 ? 164.17700 348.60400 42.78700  1.000 40.57025  ? 467 LEU F CG  1 
ATOM   3096 C CD1 . LEU A 1 432 ? 163.03500 349.13600 43.64700  1.000 35.03812  ? 467 LEU F CD1 1 
ATOM   3097 C CD2 . LEU A 1 432 ? 165.05800 347.59800 43.55800  1.000 38.21416  ? 467 LEU F CD2 1 
ATOM   3098 N N   . TYR A 1 433 ? 163.37300 351.43800 40.78900  1.000 29.60129  ? 468 TYR F N   1 
ATOM   3099 C CA  . TYR A 1 433 ? 164.10800 352.68000 40.60900  1.000 31.65534  ? 468 TYR F CA  1 
ATOM   3100 C C   . TYR A 1 433 ? 165.03000 352.81800 41.82100  1.000 34.70513  ? 468 TYR F C   1 
ATOM   3101 O O   . TYR A 1 433 ? 164.56900 353.07700 42.93400  1.000 38.49715  ? 468 TYR F O   1 
ATOM   3102 C CB  . TYR A 1 433 ? 163.15200 353.87100 40.54200  1.000 32.55368  ? 468 TYR F CB  1 
ATOM   3103 C CG  . TYR A 1 433 ? 163.74300 355.14000 39.94200  1.000 31.04917  ? 468 TYR F CG  1 
ATOM   3104 C CD1 . TYR A 1 433 ? 164.65600 355.92200 40.65500  1.000 31.05671  ? 468 TYR F CD1 1 
ATOM   3105 C CD2 . TYR A 1 433 ? 163.32400 355.59600 38.68200  1.000 29.37807  ? 468 TYR F CD2 1 
ATOM   3106 C CE1 . TYR A 1 433 ? 165.19400 357.08500 40.09100  1.000 33.36900  ? 468 TYR F CE1 1 
ATOM   3107 C CE2 . TYR A 1 433 ? 163.84500 356.74900 38.11700  1.000 27.22120  ? 468 TYR F CE2 1 
ATOM   3108 C CZ  . TYR A 1 433 ? 164.77700 357.48700 38.82000  1.000 29.89457  ? 468 TYR F CZ  1 
ATOM   3109 O OH  . TYR A 1 433 ? 165.28800 358.62400 38.24400  1.000 27.47064  ? 468 TYR F OH  1 
ATOM   3110 N N   . VAL A 1 434 ? 166.32700 352.63800 41.61500  1.000 31.16418  ? 469 VAL F N   1 
ATOM   3111 C CA  . VAL A 1 434 ? 167.31400 352.72300 42.67900  1.000 34.52267  ? 469 VAL F CA  1 
ATOM   3112 C C   . VAL A 1 434 ? 167.84900 354.14800 42.73400  1.000 39.13664  ? 469 VAL F C   1 
ATOM   3113 O O   . VAL A 1 434 ? 168.72000 354.52900 41.95500  1.000 41.27464  ? 469 VAL F O   1 
ATOM   3114 C CB  . VAL A 1 434 ? 168.43600 351.71100 42.46800  1.000 34.51431  ? 469 VAL F CB  1 
ATOM   3115 C CG1 . VAL A 1 434 ? 169.45400 351.83900 43.57000  1.000 30.86056  ? 469 VAL F CG1 1 
ATOM   3116 C CG2 . VAL A 1 434 ? 167.84500 350.29600 42.37900  1.000 35.35885  ? 469 VAL F CG2 1 
ATOM   3117 N N   . LYS A 1 435 ? 167.33300 354.94400 43.65500  1.000 41.63753  ? 470 LYS F N   1 
ATOM   3118 C CA  . LYS A 1 435 ? 167.77300 356.33000 43.73700  1.000 40.41334  ? 470 LYS F CA  1 
ATOM   3119 C C   . LYS A 1 435 ? 169.21500 356.42700 44.22900  1.000 36.31183  ? 470 LYS F C   1 
ATOM   3120 O O   . LYS A 1 435 ? 169.72900 355.54000 44.91800  1.000 35.28296  ? 470 LYS F O   1 
ATOM   3121 C CB  . LYS A 1 435 ? 166.83500 357.16400 44.61500  1.000 40.44330  ? 470 LYS F CB  1 
ATOM   3122 C CG  . LYS A 1 435 ? 165.36000 357.03200 44.25100  1.000 44.37742  ? 470 LYS F CG  1 
ATOM   3123 C CD  . LYS A 1 435 ? 164.43600 357.64400 45.31800  1.000 51.56151  ? 470 LYS F CD  1 
ATOM   3124 C CE  . LYS A 1 435 ? 163.71400 358.89800 44.79600  1.000 48.54944  ? 470 LYS F CE  1 
ATOM   3125 N NZ  . LYS A 1 435 ? 162.23000 358.81600 44.95500  1.000 51.17439  ? 470 LYS F NZ  1 
ATOM   3126 N N   . GLY A 1 436 ? 169.89600 357.47700 43.77700  1.000 34.69107  ? 471 GLY F N   1 
ATOM   3127 C CA  . GLY A 1 436 ? 171.27000 357.73700 44.15100  1.000 32.55565  ? 471 GLY F CA  1 
ATOM   3128 C C   . GLY A 1 436 ? 171.76900 358.98500 43.46200  1.000 34.20830  ? 471 GLY F C   1 
ATOM   3129 O O   . GLY A 1 436 ? 171.24000 359.37000 42.42600  1.000 34.83182  ? 471 GLY F O   1 
ATOM   3130 N N   . GLU A 1 437 ? 172.73500 359.66100 44.06900  1.000 38.46806  ? 472 GLU F N   1 
ATOM   3131 C CA  . GLU A 1 437 ? 173.29500 360.88200 43.49300  1.000 34.46777  ? 472 GLU F CA  1 
ATOM   3132 C C   . GLU A 1 437 ? 174.05900 360.54300 42.22100  1.000 38.77004  ? 472 GLU F C   1 
ATOM   3133 O O   . GLU A 1 437 ? 174.87600 359.61500 42.23500  1.000 39.30561  ? 472 GLU F O   1 
ATOM   3134 C CB  . GLU A 1 437 ? 174.22100 361.54400 44.50900  1.000 35.75327  ? 472 GLU F CB  1 
ATOM   3135 C CG  . GLU A 1 437 ? 174.94700 362.78700 44.03100  1.000 41.78491  ? 472 GLU F CG  1 
ATOM   3136 C CD  . GLU A 1 437 ? 174.16300 364.08400 44.20200  1.000 53.84521  ? 472 GLU F CD  1 
ATOM   3137 O OE1 . GLU A 1 437 ? 172.92000 364.06000 44.06800  1.000 64.17405  ? 472 GLU F OE1 1 
ATOM   3138 O OE2 . GLU A 1 437 ? 174.80200 365.14200 44.43600  1.000 59.65218  ? 472 GLU F OE2 1 
ATOM   3139 N N   . PRO A 1 438 ? 173.81200 361.22600 41.10400  1.000 38.95379  ? 473 PRO F N   1 
ATOM   3140 C CA  . PRO A 1 438 ? 174.61700 360.95600 39.90200  1.000 33.12975  ? 473 PRO F CA  1 
ATOM   3141 C C   . PRO A 1 438 ? 176.07700 361.24500 40.20200  1.000 34.87663  ? 473 PRO F C   1 
ATOM   3142 O O   . PRO A 1 438 ? 176.42500 362.33900 40.64100  1.000 37.30325  ? 473 PRO F O   1 
ATOM   3143 C CB  . PRO A 1 438 ? 174.04500 361.92600 38.86500  1.000 31.20974  ? 473 PRO F CB  1 
ATOM   3144 C CG  . PRO A 1 438 ? 172.65000 362.21700 39.35600  1.000 34.97226  ? 473 PRO F CG  1 
ATOM   3145 C CD  . PRO A 1 438 ? 172.74600 362.20700 40.85300  1.000 41.91216  ? 473 PRO F CD  1 
ATOM   3146 N N   . ILE A 1 439 ? 176.93800 360.25100 39.94700  1.000 34.93435  ? 474 ILE F N   1 
ATOM   3147 C CA  . ILE A 1 439 ? 178.35200 360.33600 40.32000  1.000 32.06245  ? 474 ILE F CA  1 
ATOM   3148 C C   . ILE A 1 439 ? 179.12600 361.39500 39.56200  1.000 35.93351  ? 474 ILE F C   1 
ATOM   3149 O O   . ILE A 1 439 ? 180.21300 361.80000 40.01700  1.000 39.19207  ? 474 ILE F O   1 
ATOM   3150 C CB  . ILE A 1 439 ? 179.04300 358.97300 40.18100  1.000 33.28657  ? 474 ILE F CB  1 
ATOM   3151 C CG1 . ILE A 1 439 ? 179.15500 358.57700 38.71200  1.000 34.53840  ? 474 ILE F CG1 1 
ATOM   3152 C CG2 . ILE A 1 439 ? 178.28600 357.95300 40.96900  1.000 33.73821  ? 474 ILE F CG2 1 
ATOM   3153 C CD1 . ILE A 1 439 ? 179.87000 357.29000 38.50000  1.000 31.16559  ? 474 ILE F CD1 1 
ATOM   3154 N N   . ILE A 1 440 ? 178.55900 361.92200 38.47300  1.000 35.12232  ? 475 ILE F N   1 
ATOM   3155 C CA  . ILE A 1 440 ? 179.24200 362.97300 37.73700  1.000 32.46043  ? 475 ILE F CA  1 
ATOM   3156 C C   . ILE A 1 440 ? 179.32800 364.23000 38.59100  1.000 34.66846  ? 475 ILE F C   1 
ATOM   3157 O O   . ILE A 1 440 ? 180.24900 365.03000 38.41000  1.000 40.92653  ? 475 ILE F O   1 
ATOM   3158 C CB  . ILE A 1 440 ? 178.50000 363.23400 36.40300  1.000 28.76712  ? 475 ILE F CB  1 
ATOM   3159 C CG1 . ILE A 1 440 ? 179.31800 364.08900 35.43800  1.000 28.76667  ? 475 ILE F CG1 1 
ATOM   3160 C CG2 . ILE A 1 440 ? 177.13800 363.86900 36.64000  1.000 32.34702  ? 475 ILE F CG2 1 
ATOM   3161 C CD1 . ILE A 1 440 ? 180.59000 363.50400 35.01100  1.000 31.49685  ? 475 ILE F CD1 1 
ATOM   3162 N N   . ASN A 1 441 ? 178.46200 364.37300 39.59400  1.000 34.43791  ? 476 ASN F N   1 
ATOM   3163 C CA  . ASN A 1 441 ? 178.51300 365.54000 40.46700  1.000 39.86013  ? 476 ASN F CA  1 
ATOM   3164 C C   . ASN A 1 441 ? 179.66400 365.47900 41.47000  1.000 40.04361  ? 476 ASN F C   1 
ATOM   3165 O O   . ASN A 1 441 ? 179.91400 366.48000 42.14500  1.000 45.79928  ? 476 ASN F O   1 
ATOM   3166 C CB  . ASN A 1 441 ? 177.18400 365.73500 41.23800  1.000 40.19372  ? 476 ASN F CB  1 
ATOM   3167 C CG  . ASN A 1 441 ? 175.97300 365.96700 40.31800  1.000 45.20125  ? 476 ASN F CG  1 
ATOM   3168 O OD1 . ASN A 1 441 ? 176.09600 366.44600 39.17700  1.000 39.97567  ? 476 ASN F OD1 1 
ATOM   3169 N ND2 . ASN A 1 441 ? 174.79100 365.67300 40.84000  1.000 45.95565  ? 476 ASN F ND2 1 
ATOM   3170 N N   . PHE A 1 442 ? 180.34100 364.33500 41.61500  1.000 39.85662  ? 477 PHE F N   1 
ATOM   3171 C CA  . PHE A 1 442 ? 181.47400 364.21700 42.53500  1.000 40.95698  ? 477 PHE F CA  1 
ATOM   3172 C C   . PHE A 1 442 ? 182.79300 364.68400 41.93000  1.000 45.07823  ? 477 PHE F C   1 
ATOM   3173 O O   . PHE A 1 442 ? 183.84700 364.55900 42.58200  1.000 43.45477  ? 477 PHE F O   1 
ATOM   3174 C CB  . PHE A 1 442 ? 181.64400 362.77100 42.98500  1.000 37.33268  ? 477 PHE F CB  1 
ATOM   3175 C CG  . PHE A 1 442 ? 180.45800 362.21400 43.69300  1.000 41.39518  ? 477 PHE F CG  1 
ATOM   3176 C CD1 . PHE A 1 442 ? 179.65300 363.03100 44.46200  1.000 39.34727  ? 477 PHE F CD1 1 
ATOM   3177 C CD2 . PHE A 1 442 ? 180.13000 360.86500 43.57200  1.000 40.75602  ? 477 PHE F CD2 1 
ATOM   3178 C CE1 . PHE A 1 442 ? 178.54500 362.50900 45.11200  1.000 40.68190  ? 477 PHE F CE1 1 
ATOM   3179 C CE2 . PHE A 1 442 ? 179.02300 360.33700 44.22100  1.000 35.40362  ? 477 PHE F CE2 1 
ATOM   3180 C CZ  . PHE A 1 442 ? 178.22800 361.15600 44.98300  1.000 37.56070  ? 477 PHE F CZ  1 
ATOM   3181 N N   . TYR A 1 443 ? 182.75600 365.22300 40.71600  1.000 42.95702  ? 478 TYR F N   1 
ATOM   3182 C CA  . TYR A 1 443 ? 183.95500 365.55700 39.97700  1.000 41.62013  ? 478 TYR F CA  1 
ATOM   3183 C C   . TYR A 1 443 ? 184.06700 367.06000 39.79100  1.000 48.11915  ? 478 TYR F C   1 
ATOM   3184 O O   . TYR A 1 443 ? 183.07500 367.72600 39.46800  1.000 48.01493  ? 478 TYR F O   1 
ATOM   3185 C CB  . TYR A 1 443 ? 183.92500 364.87200 38.61300  1.000 40.05230  ? 478 TYR F CB  1 
ATOM   3186 C CG  . TYR A 1 443 ? 184.17100 363.40100 38.70800  1.000 39.67401  ? 478 TYR F CG  1 
ATOM   3187 C CD1 . TYR A 1 443 ? 183.12700 362.53100 38.93200  1.000 39.33398  ? 478 TYR F CD1 1 
ATOM   3188 C CD2 . TYR A 1 443 ? 185.43700 362.88100 38.60200  1.000 41.92649  ? 478 TYR F CD2 1 
ATOM   3189 C CE1 . TYR A 1 443 ? 183.33900 361.17900 39.02700  1.000 37.58390  ? 478 TYR F CE1 1 
ATOM   3190 C CE2 . TYR A 1 443 ? 185.65800 361.53600 38.70400  1.000 40.88106  ? 478 TYR F CE2 1 
ATOM   3191 C CZ  . TYR A 1 443 ? 184.61300 360.68400 38.91600  1.000 37.79673  ? 478 TYR F CZ  1 
ATOM   3192 O OH  . TYR A 1 443 ? 184.86400 359.32800 39.00800  1.000 46.05649  ? 478 TYR F OH  1 
ATOM   3193 N N   . ASP A 1 444 ? 185.25800 367.59400 40.09400  1.000 51.38212  ? 479 ASP F N   1 
ATOM   3194 C CA  . ASP A 1 444 ? 185.55300 368.99300 39.84500  1.000 52.63881  ? 479 ASP F CA  1 
ATOM   3195 C C   . ASP A 1 444 ? 185.78200 369.13800 38.34000  1.000 50.69453  ? 479 ASP F C   1 
ATOM   3196 O O   . ASP A 1 444 ? 186.66600 368.47100 37.79800  1.000 52.35918  ? 479 ASP F O   1 
ATOM   3197 C CB  . ASP A 1 444 ? 186.79000 369.38200 40.68000  1.000 58.11671  ? 479 ASP F CB  1 
ATOM   3198 C CG  . ASP A 1 444 ? 187.21600 370.83300 40.49800  1.000 65.84747  ? 479 ASP F CG  1 
ATOM   3199 O OD1 . ASP A 1 444 ? 187.31200 371.31900 39.35000  1.000 64.45820  ? 479 ASP F OD1 1 
ATOM   3200 O OD2 . ASP A 1 444 ? 187.42100 371.50200 41.54300  1.000 70.55280  ? 479 ASP F OD2 1 
ATOM   3201 N N   . PRO A 1 445 ? 185.06900 370.03900 37.65100  1.000 45.78916  ? 480 PRO F N   1 
ATOM   3202 C CA  . PRO A 1 445 ? 185.20800 370.12600 36.17800  1.000 46.12602  ? 480 PRO F CA  1 
ATOM   3203 C C   . PRO A 1 445 ? 186.58600 370.51000 35.66900  1.000 52.22235  ? 480 PRO F C   1 
ATOM   3204 O O   . PRO A 1 445 ? 186.96000 370.09200 34.56400  1.000 52.07679  ? 480 PRO F O   1 
ATOM   3205 C CB  . PRO A 1 445 ? 184.14800 371.15100 35.78900  1.000 48.62167  ? 480 PRO F CB  1 
ATOM   3206 C CG  . PRO A 1 445 ? 183.11800 371.04200 36.85500  1.000 47.14745  ? 480 PRO F CG  1 
ATOM   3207 C CD  . PRO A 1 445 ? 183.66600 370.24900 38.03000  1.000 46.25004  ? 480 PRO F CD  1 
ATOM   3208 N N   . LEU A 1 446 ? 187.29900 371.39700 36.36400  1.000 58.87114  ? 481 LEU F N   1 
ATOM   3209 C CA  . LEU A 1 446 ? 188.57000 371.90700 35.84800  1.000 61.74452  ? 481 LEU F CA  1 
ATOM   3210 C C   . LEU A 1 446 ? 189.58000 370.78400 35.62300  1.000 60.50587  ? 481 LEU F C   1 
ATOM   3211 O O   . LEU A 1 446 ? 190.31500 370.80600 34.63100  1.000 66.61248  ? 481 LEU F O   1 
ATOM   3212 C CB  . LEU A 1 446 ? 189.13600 372.98800 36.76400  1.000 65.31815  ? 481 LEU F CB  1 
ATOM   3213 C CG  . LEU A 1 446 ? 188.13800 374.13100 36.98700  1.000 69.48073  ? 481 LEU F CG  1 
ATOM   3214 C CD1 . LEU A 1 446 ? 188.37500 374.82100 38.33400  1.000 70.59044  ? 481 LEU F CD1 1 
ATOM   3215 C CD2 . LEU A 1 446 ? 188.15600 375.13400 35.81500  1.000 61.96788  ? 481 LEU F CD2 1 
ATOM   3216 N N   . VAL A 1 447 ? 189.64000 369.79400 36.51700  1.000 61.83683  ? 482 VAL F N   1 
ATOM   3217 C CA  . VAL A 1 447 ? 190.65700 368.75100 36.40400  1.000 62.27319  ? 482 VAL F CA  1 
ATOM   3218 C C   . VAL A 1 447 ? 190.10400 367.45100 35.80400  1.000 56.51436  ? 482 VAL F C   1 
ATOM   3219 O O   . VAL A 1 447 ? 190.77200 366.41500 35.89100  1.000 62.61184  ? 482 VAL F O   1 
ATOM   3220 C CB  . VAL A 1 447 ? 191.31000 368.46300 37.77300  1.000 63.74960  ? 482 VAL F CB  1 
ATOM   3221 C CG1 . VAL A 1 447 ? 192.06700 369.67300 38.28800  1.000 68.45070  ? 482 VAL F CG1 1 
ATOM   3222 C CG2 . VAL A 1 447 ? 190.27300 368.02900 38.79500  1.000 65.41526  ? 482 VAL F CG2 1 
ATOM   3223 N N   . PHE A 1 448 ? 188.87800 367.46700 35.24800  1.000 51.93062  ? 483 PHE F N   1 
ATOM   3224 C CA  . PHE A 1 448 ? 188.24800 366.25500 34.69200  1.000 49.04358  ? 483 PHE F CA  1 
ATOM   3225 C C   . PHE A 1 448 ? 188.98900 365.82200 33.41100  1.000 49.62702  ? 483 PHE F C   1 
ATOM   3226 O O   . PHE A 1 448 ? 189.23900 366.65200 32.53000  1.000 55.87879  ? 483 PHE F O   1 
ATOM   3227 C CB  . PHE A 1 448 ? 186.78600 366.55300 34.36800  1.000 45.22469  ? 483 PHE F CB  1 
ATOM   3228 C CG  . PHE A 1 448 ? 185.93800 365.34200 34.10400  1.000 40.62793  ? 483 PHE F CG  1 
ATOM   3229 C CD1 . PHE A 1 448 ? 185.76100 364.39800 35.11400  1.000 37.74735  ? 483 PHE F CD1 1 
ATOM   3230 C CD2 . PHE A 1 448 ? 185.36000 365.12100 32.86700  1.000 41.27435  ? 483 PHE F CD2 1 
ATOM   3231 C CE1 . PHE A 1 448 ? 184.98000 363.29800 34.93300  1.000 34.19898  ? 483 PHE F CE1 1 
ATOM   3232 C CE2 . PHE A 1 448 ? 184.60200 363.99700 32.65400  1.000 41.33045  ? 483 PHE F CE2 1 
ATOM   3233 C CZ  . PHE A 1 448 ? 184.40700 363.07800 33.69700  1.000 36.58091  ? 483 PHE F CZ  1 
ATOM   3234 N N   . PRO A 1 449 ? 189.23100 364.52200 33.20100  1.000 45.48268  ? 484 PRO F N   1 
ATOM   3235 C CA  . PRO A 1 449 ? 189.74800 364.03600 31.90500  1.000 44.70760  ? 484 PRO F CA  1 
ATOM   3236 C C   . PRO A 1 449 ? 188.63200 363.88200 30.88500  1.000 44.33892  ? 484 PRO F C   1 
ATOM   3237 O O   . PRO A 1 449 ? 187.86700 362.91400 30.93000  1.000 48.21635  ? 484 PRO F O   1 
ATOM   3238 C CB  . PRO A 1 449 ? 190.39100 362.68900 32.26900  1.000 41.69541  ? 484 PRO F CB  1 
ATOM   3239 C CG  . PRO A 1 449 ? 190.39100 362.61700 33.75200  1.000 43.59480  ? 484 PRO F CG  1 
ATOM   3240 C CD  . PRO A 1 449 ? 189.26400 363.47100 34.22600  1.000 42.89160  ? 484 PRO F CD  1 
ATOM   3241 N N   . SER A 1 450 ? 188.55400 364.79400 29.93300  1.000 43.95663  ? 485 SER F N   1 
ATOM   3242 C CA  . SER A 1 450 ? 187.38800 364.79100 29.05500  1.000 49.28049  ? 485 SER F CA  1 
ATOM   3243 C C   . SER A 1 450 ? 187.54000 364.06300 27.71200  1.000 50.09298  ? 485 SER F C   1 
ATOM   3244 O O   . SER A 1 450 ? 186.62900 364.15000 26.87900  1.000 48.11154  ? 485 SER F O   1 
ATOM   3245 C CB  . SER A 1 450 ? 186.95400 366.24700 28.81700  1.000 54.21463  ? 485 SER F CB  1 
ATOM   3246 O OG  . SER A 1 450 ? 187.99200 367.00400 28.19200  1.000 60.64171  ? 485 SER F OG  1 
ATOM   3247 N N   . ASN A 1 451 ? 188.60800 363.30700 27.47700  1.000 47.80927  ? 486 ASN F N   1 
ATOM   3248 C CA  . ASN A 1 451 ? 188.67400 362.51700 26.24400  1.000 50.28862  ? 486 ASN F CA  1 
ATOM   3249 C C   . ASN A 1 451 ? 189.17700 361.11500 26.54000  1.000 53.79153  ? 486 ASN F C   1 
ATOM   3250 O O   . ASN A 1 451 ? 190.21200 360.67100 26.04000  1.000 62.22757  ? 486 ASN F O   1 
ATOM   3251 C CB  . ASN A 1 451 ? 189.52900 363.14800 25.14200  1.000 60.94748  ? 486 ASN F CB  1 
ATOM   3252 C CG  . ASN A 1 451 ? 188.68400 364.02400 24.14500  1.000 70.17913  ? 486 ASN F CG  1 
ATOM   3253 O OD1 . ASN A 1 451 ? 187.44700 363.87600 24.00200  1.000 61.78358  ? 486 ASN F OD1 1 
ATOM   3254 N ND2 . ASN A 1 451 ? 189.37900 364.90400 23.42200  1.000 65.86739  ? 486 ASN F ND2 1 
ATOM   3255 N N   . GLN A 1 452 ? 188.41200 360.39400 27.34300  1.000 49.73852  ? 487 GLN F N   1 
ATOM   3256 C CA  . GLN A 1 452 ? 188.81200 359.08000 27.82100  1.000 49.37446  ? 487 GLN F CA  1 
ATOM   3257 C C   . GLN A 1 452 ? 187.85200 358.04500 27.25300  1.000 49.64686  ? 487 GLN F C   1 
ATOM   3258 O O   . GLN A 1 452 ? 186.63500 358.15300 27.42500  1.000 51.11167  ? 487 GLN F O   1 
ATOM   3259 C CB  . GLN A 1 452 ? 188.83400 359.04300 29.34500  1.000 44.33677  ? 487 GLN F CB  1 
ATOM   3260 C CG  . GLN A 1 452 ? 189.60600 360.19800 29.98500  1.000 51.07010  ? 487 GLN F CG  1 
ATOM   3261 C CD  . GLN A 1 452 ? 191.12000 360.16300 29.72100  1.000 49.96982  ? 487 GLN F CD  1 
ATOM   3262 O OE1 . GLN A 1 452 ? 191.72500 359.09400 29.74400  1.000 47.80651  ? 487 GLN F OE1 1 
ATOM   3263 N NE2 . GLN A 1 452 ? 191.73300 361.34700 29.49400  1.000 45.26554  ? 487 GLN F NE2 1 
ATOM   3264 N N   . PHE A 1 453 ? 188.40100 357.07600 26.54000  1.000 54.70982  ? 488 PHE F N   1 
ATOM   3265 C CA  . PHE A 1 453 ? 187.66700 355.94900 25.98800  1.000 52.70193  ? 488 PHE F CA  1 
ATOM   3266 C C   . PHE A 1 453 ? 188.28200 354.72000 26.62200  1.000 57.71898  ? 488 PHE F C   1 
ATOM   3267 O O   . PHE A 1 453 ? 189.50900 354.57000 26.66100  1.000 70.94203  ? 488 PHE F O   1 
ATOM   3268 C CB  . PHE A 1 453 ? 187.73500 355.98200 24.46100  1.000 52.37690  ? 488 PHE F CB  1 
ATOM   3269 C CG  . PHE A 1 453 ? 187.67800 357.39300 23.92400  1.000 67.34414  ? 488 PHE F CG  1 
ATOM   3270 C CD1 . PHE A 1 453 ? 188.83400 358.18000 23.88200  1.000 71.02890  ? 488 PHE F CD1 1 
ATOM   3271 C CD2 . PHE A 1 453 ? 186.45100 357.99800 23.60100  1.000 69.57869  ? 488 PHE F CD2 1 
ATOM   3272 C CE1 . PHE A 1 453 ? 188.79400 359.52400 23.45000  1.000 68.47569  ? 488 PHE F CE1 1 
ATOM   3273 C CE2 . PHE A 1 453 ? 186.39400 359.34900 23.15700  1.000 67.77820  ? 488 PHE F CE2 1 
ATOM   3274 C CZ  . PHE A 1 453 ? 187.57200 360.10600 23.08100  1.000 68.69328  ? 488 PHE F CZ  1 
ATOM   3275 N N   . ASP A 1 454 ? 187.44000 353.90100 27.19200  1.000 51.03215  ? 489 ASP F N   1 
ATOM   3276 C CA  . ASP A 1 454 ? 187.85900 352.69200 27.89000  1.000 54.98629  ? 489 ASP F CA  1 
ATOM   3277 C C   . ASP A 1 454 ? 188.75200 352.99100 29.09400  1.000 52.44819  ? 489 ASP F C   1 
ATOM   3278 O O   . ASP A 1 454 ? 189.87600 352.50100 29.19200  1.000 61.28708  ? 489 ASP F O   1 
ATOM   3279 C CB  . ASP A 1 454 ? 188.61100 351.78300 26.89700  1.000 58.37605  ? 489 ASP F CB  1 
ATOM   3280 C CG  . ASP A 1 454 ? 188.52600 350.29100 27.23900  1.000 69.49271  ? 489 ASP F CG  1 
ATOM   3281 O OD1 . ASP A 1 454 ? 187.50700 349.81900 27.80700  1.000 71.39858  ? 489 ASP F OD1 1 
ATOM   3282 O OD2 . ASP A 1 454 ? 189.51200 349.58300 26.92200  1.000 70.15534  ? 489 ASP F OD2 1 
ATOM   3283 N N   . ALA A 1 455 ? 188.27700 353.87100 29.96600  1.000 48.26562  ? 490 ALA F N   1 
ATOM   3284 C CA  . ALA A 1 455 ? 189.02100 354.29000 31.14300  1.000 50.93547  ? 490 ALA F CA  1 
ATOM   3285 C C   . ALA A 1 455 ? 188.36500 353.65600 32.36600  1.000 50.85353  ? 490 ALA F C   1 
ATOM   3286 O O   . ALA A 1 455 ? 187.14900 353.49500 32.41700  1.000 54.69660  ? 490 ALA F O   1 
ATOM   3287 C CB  . ALA A 1 455 ? 189.09900 355.80600 31.29000  1.000 54.12226  ? 490 ALA F CB  1 
ATOM   3288 N N   . SER A 1 456 ? 189.14700 353.30000 33.34600  1.000 52.21088  ? 491 SER F N   1 
ATOM   3289 C CA  . SER A 1 456 ? 188.65300 352.77300 34.60500  1.000 50.92274  ? 491 SER F CA  1 
ATOM   3290 C C   . SER A 1 456 ? 188.32200 353.91500 35.55600  1.000 54.97757  ? 491 SER F C   1 
ATOM   3291 O O   . SER A 1 456 ? 188.76700 355.04500 35.36700  1.000 57.69566  ? 491 SER F O   1 
ATOM   3292 C CB  . SER A 1 456 ? 189.64100 351.83700 35.25500  1.000 55.16994  ? 491 SER F CB  1 
ATOM   3293 O OG  . SER A 1 456 ? 190.55400 352.56000 36.05700  1.000 63.71506  ? 491 SER F OG  1 
ATOM   3294 N N   . ILE A 1 457 ? 187.48600 353.62700 36.55400  1.000 52.54791  ? 492 ILE F N   1 
ATOM   3295 C CA  . ILE A 1 457 ? 187.16800 354.63500 37.56200  1.000 50.14079  ? 492 ILE F CA  1 
ATOM   3296 C C   . ILE A 1 457 ? 188.45900 355.04500 38.26700  1.000 56.69740  ? 492 ILE F C   1 
ATOM   3297 O O   . ILE A 1 457 ? 188.72000 356.23300 38.51400  1.000 58.12405  ? 492 ILE F O   1 
ATOM   3298 C CB  . ILE A 1 457 ? 186.17100 354.08100 38.59800  1.000 49.10115  ? 492 ILE F CB  1 
ATOM   3299 C CG1 . ILE A 1 457 ? 184.72300 354.19600 38.12300  1.000 38.05598  ? 492 ILE F CG1 1 
ATOM   3300 C CG2 . ILE A 1 457 ? 186.44600 354.72700 39.96300  1.000 50.71070  ? 492 ILE F CG2 1 
ATOM   3301 C CD1 . ILE A 1 457 ? 184.24300 355.60800 38.06200  1.000 42.49855  ? 492 ILE F CD1 1 
ATOM   3302 N N   . SER A 1 458 ? 189.23500 354.03800 38.70200  1.000 63.84396  ? 493 SER F N   1 
ATOM   3303 C CA  . SER A 1 458 ? 190.51400 354.28500 39.36100  1.000 63.07246  ? 493 SER F CA  1 
ATOM   3304 C C   . SER A 1 458 ? 191.53700 354.91800 38.42900  1.000 63.37232  ? 493 SER F C   1 
ATOM   3305 O O   . SER A 1 458 ? 192.38700 355.69200 38.87900  1.000 69.62525  ? 493 SER F O   1 
ATOM   3306 C CB  . SER A 1 458 ? 191.08100 352.97100 39.89700  1.000 60.10728  ? 493 SER F CB  1 
ATOM   3307 O OG  . SER A 1 458 ? 190.72000 352.77300 41.24700  1.000 69.40890  ? 493 SER F OG  1 
ATOM   3308 N N   . GLN A 1 459 ? 191.46000 354.64500 37.13300  1.000 61.02530  ? 494 GLN F N   1 
ATOM   3309 C CA  . GLN A 1 459 ? 192.38300 355.31700 36.22200  1.000 66.02232  ? 494 GLN F CA  1 
ATOM   3310 C C   . GLN A 1 459 ? 192.07600 356.82500 36.19500  1.000 67.96160  ? 494 GLN F C   1 
ATOM   3311 O O   . GLN A 1 459 ? 192.99900 357.66000 36.20200  1.000 73.49650  ? 494 GLN F O   1 
ATOM   3312 C CB  . GLN A 1 459 ? 192.45300 354.57400 34.87500  1.000 64.78124  ? 494 GLN F CB  1 
ATOM   3313 C CG  . GLN A 1 459 ? 193.08000 355.30500 33.68900  1.000 69.34070  ? 494 GLN F CG  1 
ATOM   3314 C CD  . GLN A 1 459 ? 192.91400 354.53700 32.37000  1.000 70.18491  ? 494 GLN F CD  1 
ATOM   3315 O OE1 . GLN A 1 459 ? 192.52100 353.35700 32.36200  1.000 61.52331  ? 494 GLN F OE1 1 
ATOM   3316 N NE2 . GLN A 1 459 ? 193.26900 355.18700 31.25300  1.000 62.71281  ? 494 GLN F NE2 1 
ATOM   3317 N N   . VAL A 1 460 ? 190.78600 357.19100 36.16300  1.000 64.11613  ? 495 VAL F N   1 
ATOM   3318 C CA  . VAL A 1 460 ? 190.40100 358.59700 36.11800  1.000 59.36386  ? 495 VAL F CA  1 
ATOM   3319 C C   . VAL A 1 460 ? 190.81900 359.24700 37.42800  1.000 62.16865  ? 495 VAL F C   1 
ATOM   3320 O O   . VAL A 1 460 ? 191.25400 360.41100 37.45700  1.000 68.57073  ? 495 VAL F O   1 
ATOM   3321 C CB  . VAL A 1 460 ? 188.88200 358.72100 35.86400  1.000 52.89691  ? 495 VAL F CB  1 
ATOM   3322 C CG1 . VAL A 1 460 ? 188.45100 360.14200 35.95400  1.000 49.48147  ? 495 VAL F CG1 1 
ATOM   3323 C CG2 . VAL A 1 460 ? 188.56300 358.22900 34.46900  1.000 45.84390  ? 495 VAL F CG2 1 
ATOM   3324 N N   . ASN A 1 461 ? 190.64700 358.52900 38.53900  1.000 61.29512  ? 496 ASN F N   1 
ATOM   3325 C CA  . ASN A 1 461 ? 191.04100 359.09900 39.81000  1.000 64.67119  ? 496 ASN F CA  1 
ATOM   3326 C C   . ASN A 1 461 ? 192.55200 359.35200 39.84800  1.000 71.62827  ? 496 ASN F C   1 
ATOM   3327 O O   . ASN A 1 461 ? 193.00000 360.32900 40.45800  1.000 76.58117  ? 496 ASN F O   1 
ATOM   3328 C CB  . ASN A 1 461 ? 190.55200 358.24000 40.98700  1.000 63.53837  ? 496 ASN F CB  1 
ATOM   3329 C CG  . ASN A 1 461 ? 189.04400 358.38400 41.23100  1.000 67.95373  ? 496 ASN F CG  1 
ATOM   3330 O OD1 . ASN A 1 461 ? 188.31000 358.83000 40.34600  1.000 65.34191  ? 496 ASN F OD1 1 
ATOM   3331 N ND2 . ASN A 1 461 ? 188.60000 358.10900 42.45900  1.000 66.54282  ? 496 ASN F ND2 1 
ATOM   3332 N N   . GLU A 1 462 ? 193.36300 358.46500 39.23600  1.000 76.57465  ? 497 GLU F N   1 
ATOM   3333 C CA  . GLU A 1 462 ? 194.81400 358.72100 39.19800  1.000 81.00888  ? 497 GLU F CA  1 
ATOM   3334 C C   . GLU A 1 462 ? 195.16900 359.92500 38.32300  1.000 77.45651  ? 497 GLU F C   1 
ATOM   3335 O O   . GLU A 1 462 ? 196.07000 360.70300 38.67500  1.000 81.66923  ? 497 GLU F O   1 
ATOM   3336 C CB  . GLU A 1 462 ? 195.61100 357.49100 38.70600  1.000 84.80864  ? 497 GLU F CB  1 
ATOM   3337 C CG  . GLU A 1 462 ? 196.04100 357.49400 37.20400  1.000 79.75292  ? 497 GLU F CG  1 
ATOM   3338 C CD  . GLU A 1 462 ? 196.48600 356.11300 36.65900  1.000 82.01566  ? 497 GLU F CD  1 
ATOM   3339 O OE1 . GLU A 1 462 ? 196.93100 355.24600 37.46600  1.000 78.94470  ? 497 GLU F OE1 1 
ATOM   3340 O OE2 . GLU A 1 462 ? 196.40300 355.91200 35.41400  1.000 76.63644  ? 497 GLU F OE2 1 
ATOM   3341 N N   . LYS A 1 463 ? 194.46600 360.12600 37.19800  1.000 73.33958  ? 498 LYS F N   1 
ATOM   3342 C CA  . LYS A 1 463 ? 194.72900 361.34800 36.43400  1.000 70.31776  ? 498 LYS F CA  1 
ATOM   3343 C C   . LYS A 1 463 ? 194.31200 362.59200 37.21300  1.000 71.66890  ? 498 LYS F C   1 
ATOM   3344 O O   . LYS A 1 463 ? 194.94500 363.64700 37.08600  1.000 73.44970  ? 498 LYS F O   1 
ATOM   3345 C CB  . LYS A 1 463 ? 194.12200 361.31600 35.03900  1.000 63.14468  ? 498 LYS F CB  1 
ATOM   3346 C CG  . LYS A 1 463 ? 194.88200 360.38800 34.11700  1.000 59.47960  ? 498 LYS F CG  1 
ATOM   3347 C CD  . LYS A 1 463 ? 194.26600 360.30400 32.74000  1.000 47.93987  ? 498 LYS F CD  1 
ATOM   3348 C CE  . LYS A 1 463 ? 195.32500 359.76000 31.75700  1.000 64.52066  ? 498 LYS F CE  1 
ATOM   3349 N NZ  . LYS A 1 463 ? 194.92300 359.64200 30.30500  1.000 55.08052  ? 498 LYS F NZ  1 
ATOM   3350 N N   . ILE A 1 464 ? 193.32100 362.46600 38.09000  1.000 69.81792  ? 499 ILE F N   1 
ATOM   3351 C CA  . ILE A 1 464 ? 192.94300 363.61300 38.90400  1.000 74.16030  ? 499 ILE F CA  1 
ATOM   3352 C C   . ILE A 1 464 ? 193.94800 363.84500 40.02700  1.000 83.29255  ? 499 ILE F C   1 
ATOM   3353 O O   . ILE A 1 464 ? 194.25100 364.99200 40.35900  1.000 90.72603  ? 499 ILE F O   1 
ATOM   3354 C CB  . ILE A 1 464 ? 191.53500 363.40400 39.48200  1.000 65.73858  ? 499 ILE F CB  1 
ATOM   3355 C CG1 . ILE A 1 464 ? 190.49600 363.26600 38.38200  1.000 62.64786  ? 499 ILE F CG1 1 
ATOM   3356 C CG2 . ILE A 1 464 ? 191.20000 364.48500 40.49400  1.000 67.54512  ? 499 ILE F CG2 1 
ATOM   3357 C CD1 . ILE A 1 464 ? 189.12700 362.98900 38.94000  1.000 59.78293  ? 499 ILE F CD1 1 
ATOM   3358 N N   . ASN A 1 465 ? 194.48800 362.78200 40.63400  1.000 82.02638  ? 500 ASN F N   1 
ATOM   3359 C CA  . ASN A 1 465 ? 195.51500 362.96800 41.66400  1.000 85.58821  ? 500 ASN F CA  1 
ATOM   3360 C C   . ASN A 1 465 ? 196.80500 363.55900 41.09000  1.000 90.27518  ? 500 ASN F C   1 
ATOM   3361 O O   . ASN A 1 465 ? 197.41100 364.46200 41.70300  1.000 95.28857  ? 500 ASN F O   1 
ATOM   3362 C CB  . ASN A 1 465 ? 195.84300 361.62100 42.32300  1.000 85.73009  ? 500 ASN F CB  1 
ATOM   3363 C CG  . ASN A 1 465 ? 194.81100 361.16100 43.34400  1.000 87.82812  ? 500 ASN F CG  1 
ATOM   3364 O OD1 . ASN A 1 465 ? 193.68300 361.64900 43.39000  1.000 89.01730  ? 500 ASN F OD1 1 
ATOM   3365 N ND2 . ASN A 1 465 ? 195.21400 360.16400 44.15900  1.000 96.89801  ? 500 ASN F ND2 1 
ATOM   3366 N N   . GLN A 1 466 ? 197.12800 363.21600 39.83500  1.000 87.10217  ? 501 GLN F N   1 
ATOM   3367 C CA  . GLN A 1 466 ? 198.31900 363.78900 39.21400  1.000 86.94887  ? 501 GLN F CA  1 
ATOM   3368 C C   . GLN A 1 466 ? 198.08500 365.22900 38.78500  1.000 94.36825  ? 501 GLN F C   1 
ATOM   3369 O O   . GLN A 1 466 ? 199.01800 366.04500 38.83100  1.000 100.91418 ? 501 GLN F O   1 
ATOM   3370 C CB  . GLN A 1 466 ? 198.74800 362.99600 37.97600  1.000 84.73009  ? 501 GLN F CB  1 
ATOM   3371 C CG  . GLN A 1 466 ? 197.97100 363.37900 36.70100  1.000 82.59180  ? 501 GLN F CG  1 
ATOM   3372 C CD  . GLN A 1 466 ? 198.47300 362.66500 35.45100  1.000 84.38613  ? 501 GLN F CD  1 
ATOM   3373 O OE1 . GLN A 1 466 ? 199.21100 361.67800 35.53500  1.000 83.98698  ? 501 GLN F OE1 1 
ATOM   3374 N NE2 . GLN A 1 466 ? 198.10300 363.19200 34.28300  1.000 80.55541  ? 501 GLN F NE2 1 
ATOM   3375 N N   . SER A 1 467 ? 196.84800 365.56300 38.39700  1.000 92.62175  ? 502 SER F N   1 
ATOM   3376 C CA  . SER A 1 467 ? 196.51700 366.92800 38.01400  1.000 91.22965  ? 502 SER F CA  1 
ATOM   3377 C C   . SER A 1 467 ? 196.33700 367.80100 39.24400  1.000 94.06175  ? 502 SER F C   1 
ATOM   3378 O O   . SER A 1 467 ? 196.41100 369.02800 39.13400  1.000 100.90230 ? 502 SER F O   1 
ATOM   3379 C CB  . SER A 1 467 ? 195.28400 366.96000 37.11100  1.000 89.21311  ? 502 SER F CB  1 
ATOM   3380 O OG  . SER A 1 467 ? 195.67700 366.93800 35.74300  1.000 83.97956  ? 502 SER F OG  1 
ATOM   3381 N N   . LEU A 1 468 ? 196.04500 367.18700 40.39300  1.000 91.49515  ? 503 LEU F N   1 
ATOM   3382 C CA  . LEU A 1 468 ? 195.94800 367.90400 41.65600  1.000 99.03146  ? 503 LEU F CA  1 
ATOM   3383 C C   . LEU A 1 468 ? 197.33100 368.23600 42.21000  1.000 105.53702 ? 503 LEU F C   1 
ATOM   3384 O O   . LEU A 1 468 ? 197.47200 369.18800 42.99400  1.000 105.54175 ? 503 LEU F O   1 
ATOM   3385 C CB  . LEU A 1 468 ? 195.19600 367.04600 42.67300  1.000 93.06381  ? 503 LEU F CB  1 
ATOM   3386 C CG  . LEU A 1 468 ? 193.68100 366.91600 42.54700  1.000 94.50608  ? 503 LEU F CG  1 
ATOM   3387 C CD1 . LEU A 1 468 ? 193.13700 366.01200 43.65900  1.000 88.99367  ? 503 LEU F CD1 1 
ATOM   3388 C CD2 . LEU A 1 468 ? 193.01800 368.29100 42.56100  1.000 92.32655  ? 503 LEU F CD2 1 
ATOM   3389 N N   . ALA A 1 469 ? 198.35000 367.43100 41.86800  1.000 105.52726 ? 504 ALA F N   1 
ATOM   3390 C CA  . ALA A 1 469 ? 199.71500 367.78800 42.28100  1.000 112.15776 ? 504 ALA F CA  1 
ATOM   3391 C C   . ALA A 1 469 ? 200.29400 369.03100 41.56700  1.000 115.01815 ? 504 ALA F C   1 
ATOM   3392 O O   . ALA A 1 469 ? 201.08300 369.76800 42.17600  1.000 115.37389 ? 504 ALA F O   1 
ATOM   3393 C CB  . ALA A 1 469 ? 200.64700 366.59900 42.05700  1.000 107.29690 ? 504 ALA F CB  1 
ATOM   3394 N N   . PHE A 1 470 ? 199.92500 369.30000 40.29900  1.000 112.94015 ? 505 PHE F N   1 
ATOM   3395 C CA  . PHE A 1 470 ? 200.40700 370.50800 39.60700  1.000 111.36402 ? 505 PHE F CA  1 
ATOM   3396 C C   . PHE A 1 470 ? 199.83000 371.79500 40.18700  1.000 108.23237 ? 505 PHE F C   1 
ATOM   3397 O O   . PHE A 1 470 ? 200.42000 372.86600 40.00700  1.000 107.19581 ? 505 PHE F O   1 
ATOM   3398 C CB  . PHE A 1 470 ? 200.06200 370.51000 38.10400  1.000 108.82330 ? 505 PHE F CB  1 
ATOM   3399 C CG  . PHE A 1 470 ? 200.60600 369.33600 37.30900  1.000 114.65044 ? 505 PHE F CG  1 
ATOM   3400 C CD1 . PHE A 1 470 ? 201.78900 368.69800 37.66200  1.000 113.97591 ? 505 PHE F CD1 1 
ATOM   3401 C CD2 . PHE A 1 470 ? 199.95000 368.92300 36.14600  1.000 113.17334 ? 505 PHE F CD2 1 
ATOM   3402 C CE1 . PHE A 1 470 ? 202.27600 367.63100 36.89900  1.000 107.49621 ? 505 PHE F CE1 1 
ATOM   3403 C CE2 . PHE A 1 470 ? 200.43300 367.86600 35.38000  1.000 107.38930 ? 505 PHE F CE2 1 
ATOM   3404 C CZ  . PHE A 1 470 ? 201.59700 367.22200 35.75600  1.000 105.44582 ? 505 PHE F CZ  1 
ATOM   3405 N N   . ILE A 1 471 ? 198.72800 371.68500 40.92800  1.000 111.88013 ? 506 ILE F N   1 
ATOM   3406 C CA  . ILE A 1 471 ? 197.98900 372.75500 41.59700  1.000 117.67364 ? 506 ILE F CA  1 
ATOM   3407 C C   . ILE A 1 471 ? 198.41500 372.82900 43.05200  1.000 116.41882 ? 506 ILE F C   1 
ATOM   3408 O O   . ILE A 1 471 ? 198.25600 373.86600 43.71000  1.000 116.67462 ? 506 ILE F O   1 
ATOM   3409 C CB  . ILE A 1 471 ? 196.47000 372.54700 41.45100  1.000 112.23741 ? 506 ILE F CB  1 
ATOM   3410 C CG1 . ILE A 1 471 ? 196.14200 372.26500 39.97700  1.000 104.35134 ? 506 ILE F CG1 1 
ATOM   3411 C CG2 . ILE A 1 471 ? 195.70000 373.74900 42.00400  1.000 102.91466 ? 506 ILE F CG2 1 
ATOM   3412 C CD1 . ILE A 1 471 ? 194.70000 372.00800 39.69400  1.000 98.21094  ? 506 ILE F CD1 1 
ATOM   3413 N N   . ARG A 1 472 ? 198.89700 371.70900 43.58200  1.000 111.38262 ? 507 ARG F N   1 
ATOM   3414 C CA  . ARG A 1 472 ? 199.34600 371.70500 44.96500  1.000 119.55631 ? 507 ARG F CA  1 
ATOM   3415 C C   . ARG A 1 472 ? 200.53200 372.66200 45.11600  1.000 122.45407 ? 507 ARG F C   1 
ATOM   3416 O O   . ARG A 1 472 ? 200.57500 373.47200 46.05500  1.000 121.42511 ? 507 ARG F O   1 
ATOM   3417 C CB  . ARG A 1 472 ? 199.70600 370.27200 45.36200  1.000 121.42746 ? 507 ARG F CB  1 
ATOM   3418 C CG  . ARG A 1 472 ? 200.51400 370.08100 46.63100  1.000 122.99498 ? 507 ARG F CG  1 
ATOM   3419 C CD  . ARG A 1 472 ? 200.77800 368.58700 46.81700  1.000 130.69355 ? 507 ARG F CD  1 
ATOM   3420 N NE  . ARG A 1 472 ? 200.51300 368.10100 48.16800  1.000 137.09625 ? 507 ARG F NE  1 
ATOM   3421 C CZ  . ARG A 1 472 ? 200.63300 366.83200 48.54700  1.000 134.40915 ? 507 ARG F CZ  1 
ATOM   3422 N NH1 . ARG A 1 472 ? 201.01200 365.88700 47.69700  1.000 127.45669 ? 507 ARG F NH1 1 
ATOM   3423 N NH2 . ARG A 1 472 ? 200.36500 366.50300 49.80900  1.000 131.13857 ? 507 ARG F NH2 1 
ATOM   3424 N N   . LYS A 1 473 ? 201.49100 372.60800 44.17800  1.000 118.76023 ? 508 LYS F N   1 
ATOM   3425 C CA  . LYS A 1 473 ? 202.65100 373.49700 44.23200  1.000 113.85296 ? 508 LYS F CA  1 
ATOM   3426 C C   . LYS A 1 473 ? 202.26400 374.95600 43.99800  1.000 114.67978 ? 508 LYS F C   1 
ATOM   3427 O O   . LYS A 1 473 ? 202.90900 375.86200 44.54200  1.000 115.58597 ? 508 LYS F O   1 
ATOM   3428 C CB  . LYS A 1 473 ? 203.69100 373.08800 43.18400  1.000 112.00293 ? 508 LYS F CB  1 
ATOM   3429 C CG  . LYS A 1 473 ? 204.03800 371.60800 43.13900  1.000 116.85272 ? 508 LYS F CG  1 
ATOM   3430 C CD  . LYS A 1 473 ? 204.71500 371.17100 44.43100  1.000 111.39805 ? 508 LYS F CD  1 
ATOM   3431 C CE  . LYS A 1 473 ? 205.48700 369.87400 44.25400  1.000 106.26009 ? 508 LYS F CE  1 
ATOM   3432 N NZ  . LYS A 1 473 ? 204.58500 368.70300 44.17600  1.000 107.67091 ? 508 LYS F NZ  1 
ATOM   3433 N N   . SER A 1 474 ? 201.20600 375.20100 43.22500  1.000 116.46451 ? 509 SER F N   1 
ATOM   3434 C CA  . SER A 1 474 ? 200.73500 376.55700 42.92200  1.000 111.13896 ? 509 SER F CA  1 
ATOM   3435 C C   . SER A 1 474 ? 199.48700 376.94300 43.72600  1.000 103.99364 ? 509 SER F C   1 
ATOM   3436 O O   . SER A 1 474 ? 199.58100 377.38200 44.87600  1.000 96.84848  ? 509 SER F O   1 
ATOM   3437 C CB  . SER A 1 474 ? 200.43700 376.67300 41.41900  1.000 105.93818 ? 509 SER F CB  1 
ATOM   3438 O OG  . SER A 1 474 ? 201.62400 376.62000 40.63800  1.000 97.45097  ? 509 SER F OG  1 
HETATM 3439 C C1  . EDO B 2 .   ? 187.28200 335.30000 38.54900  1.000 41.14497  ? 601 EDO F C1  1 
HETATM 3440 O O1  . EDO B 2 .   ? 188.35500 335.30800 37.57300  1.000 47.55882  ? 601 EDO F O1  1 
HETATM 3441 C C2  . EDO B 2 .   ? 185.96600 334.91700 37.83100  1.000 36.76310  ? 601 EDO F C2  1 
HETATM 3442 O O2  . EDO B 2 .   ? 184.82500 334.76600 38.70000  1.000 35.18741  ? 601 EDO F O2  1 
HETATM 3443 H H11 . EDO B 2 .   ? 187.18500 336.28700 39.00800  1.000 50.00795  ? 601 EDO F H11 1 
HETATM 3444 H H12 . EDO B 2 .   ? 187.50000 334.58100 39.34100  1.000 50.00795  ? 601 EDO F H12 1 
HETATM 3445 H HO1 . EDO B 2 .   ? 189.20500 335.38000 38.02900  1.000 57.70458  ? 601 EDO F HO1 1 
HETATM 3446 H H21 . EDO B 2 .   ? 186.12300 333.97600 37.29900  1.000 44.74972  ? 601 EDO F H21 1 
HETATM 3447 H H22 . EDO B 2 .   ? 185.73800 335.68600 37.09000  1.000 44.74972  ? 601 EDO F H22 1 
HETATM 3448 H HO2 . EDO B 2 .   ? 184.05300 334.50700 38.17800  1.000 42.85889  ? 601 EDO F HO2 1 
HETATM 3449 C C1  . NAG C 3 .   ? 194.52200 359.47800 45.24500  1.000 105.09700 ? 602 NAG F C1  1 
HETATM 3450 C C2  . NAG C 3 .   ? 194.40300 357.95100 45.10100  1.000 110.34359 ? 602 NAG F C2  1 
HETATM 3451 C C3  . NAG C 3 .   ? 193.62100 357.38500 46.28800  1.000 112.14814 ? 602 NAG F C3  1 
HETATM 3452 C C4  . NAG C 3 .   ? 194.27900 357.77800 47.61000  1.000 111.53343 ? 602 NAG F C4  1 
HETATM 3453 C C5  . NAG C 3 .   ? 194.55900 359.28700 47.70600  1.000 107.30799 ? 602 NAG F C5  1 
HETATM 3454 C C6  . NAG C 3 .   ? 195.48100 359.62400 48.86200  1.000 95.89372  ? 602 NAG F C6  1 
HETATM 3455 C C7  . NAG C 3 .   ? 194.46300 356.99200 42.81700  1.000 95.79947  ? 602 NAG F C7  1 
HETATM 3456 C C8  . NAG C 3 .   ? 193.64500 356.61600 41.62000  1.000 86.09832  ? 602 NAG F C8  1 
HETATM 3457 N N2  . NAG C 3 .   ? 193.79000 357.54600 43.84000  1.000 103.92115 ? 602 NAG F N2  1 
HETATM 3458 O O3  . NAG C 3 .   ? 193.52600 355.96600 46.18100  1.000 104.46830 ? 602 NAG F O3  1 
HETATM 3459 O O4  . NAG C 3 .   ? 193.43200 357.40500 48.69500  1.000 106.46185 ? 602 NAG F O4  1 
HETATM 3460 O O5  . NAG C 3 .   ? 195.19000 359.79500 46.51300  1.000 108.78310 ? 602 NAG F O5  1 
HETATM 3461 O O6  . NAG C 3 .   ? 195.66900 361.02200 49.04000  1.000 80.76414  ? 602 NAG F O6  1 
HETATM 3462 O O7  . NAG C 3 .   ? 195.67800 356.81400 42.85100  1.000 96.32580  ? 602 NAG F O7  1 
HETATM 3463 O O   . HOH D 4 .   ? 183.77400 348.72700 33.42900  1.000 38.08420  ? 701 HOH F O   1 
HETATM 3464 O O   . HOH D 4 .   ? 178.47500 331.69000 -8.21600  1.000 39.87838  ? 702 HOH F O   1 
HETATM 3465 O O   . HOH D 4 .   ? 157.29000 342.87400 23.20600  1.000 43.41354  ? 703 HOH F O   1 
HETATM 3466 O O   . HOH D 4 .   ? 169.54400 303.58400 9.77500   1.000 53.74036  ? 704 HOH F O   1 
HETATM 3467 O O   . HOH D 4 .   ? 182.88000 333.77300 27.58800  1.000 28.05475  ? 705 HOH F O   1 
HETATM 3468 O O   . HOH D 4 .   ? 166.53800 352.09900 22.56300  1.000 34.45264  ? 706 HOH F O   1 
HETATM 3469 O O   . HOH D 4 .   ? 160.36500 367.57700 34.13800  1.000 29.06718  ? 707 HOH F O   1 
HETATM 3470 O O   . HOH D 4 .   ? 171.26200 354.80000 41.88300  1.000 32.80853  ? 708 HOH F O   1 
HETATM 3471 O O   . HOH D 4 .   ? 172.86300 341.10200 37.78700  1.000 34.58490  ? 709 HOH F O   1 
HETATM 3472 O O   . HOH D 4 .   ? 166.00400 363.12200 32.06800  1.000 25.61540  ? 710 HOH F O   1 
HETATM 3473 O O   . HOH D 4 .   ? 170.75300 360.57200 36.45900  1.000 35.89962  ? 711 HOH F O   1 
HETATM 3474 O O   . HOH D 4 .   ? 171.84300 356.47100 25.64900  1.000 30.54192  ? 712 HOH F O   1 
HETATM 3475 O O   . HOH D 4 .   ? 159.96300 363.79900 13.75000  1.000 25.19917  ? 713 HOH F O   1 
HETATM 3476 O O   . HOH D 4 .   ? 179.60000 330.34800 37.46600  1.000 30.08469  ? 714 HOH F O   1 
HETATM 3477 O O   . HOH D 4 .   ? 155.83600 360.12700 23.26600  1.000 32.42860  ? 715 HOH F O   1 
HETATM 3478 O O   . HOH D 4 .   ? 178.36700 327.77600 34.93300  1.000 34.34999  ? 716 HOH F O   1 
HETATM 3479 O O   . HOH D 4 .   ? 170.93200 367.21500 36.89300  1.000 41.76961  ? 717 HOH F O   1 
HETATM 3480 O O   . HOH D 4 .   ? 166.26400 362.29100 18.54300  1.000 24.45072  ? 718 HOH F O   1 
HETATM 3481 O O   . HOH D 4 .   ? 176.09700 355.13300 31.96300  1.000 25.97038  ? 719 HOH F O   1 
HETATM 3482 O O   . HOH D 4 .   ? 158.06000 354.39700 36.13500  1.000 30.54668  ? 720 HOH F O   1 
HETATM 3483 O O   . HOH D 4 .   ? 180.01800 348.36800 32.83700  1.000 28.68618  ? 721 HOH F O   1 
HETATM 3484 O O   . HOH D 4 .   ? 162.02500 321.65000 -3.96700  1.000 39.40394  ? 722 HOH F O   1 
HETATM 3485 O O   . HOH D 4 .   ? 169.06900 375.86700 27.38600  1.000 40.84247  ? 723 HOH F O   1 
HETATM 3486 O O   . HOH D 4 .   ? 169.65800 329.78200 -13.30100 1.000 46.97563  ? 724 HOH F O   1 
HETATM 3487 O O   . HOH D 4 .   ? 174.25400 323.72700 31.61400  1.000 29.45833  ? 725 HOH F O   1 
HETATM 3488 O O   . HOH D 4 .   ? 183.11400 346.05000 32.33300  1.000 38.43296  ? 726 HOH F O   1 
HETATM 3489 O O   . HOH D 4 .   ? 180.78700 350.20200 34.33000  1.000 33.73649  ? 727 HOH F O   1 
HETATM 3490 O O   . HOH D 4 .   ? 174.26900 342.11200 22.62200  1.000 44.15652  ? 728 HOH F O   1 
HETATM 3491 O O   . HOH D 4 .   ? 159.69500 365.21600 21.99900  1.000 33.23725  ? 729 HOH F O   1 
HETATM 3492 O O   . HOH D 4 .   ? 164.29100 310.78500 -3.63200  1.000 45.59570  ? 730 HOH F O   1 
HETATM 3493 O O   . HOH D 4 .   ? 158.02700 321.51500 -25.26900 1.000 39.58613  ? 731 HOH F O   1 
HETATM 3494 O O   . HOH D 4 .   ? 168.34700 362.95400 19.99800  1.000 27.33686  ? 732 HOH F O   1 
HETATM 3495 O O   . HOH D 4 .   ? 171.81900 369.88600 29.88800  1.000 38.61854  ? 733 HOH F O   1 
HETATM 3496 O O   . HOH D 4 .   ? 181.64800 326.58800 29.34100  1.000 24.89753  ? 734 HOH F O   1 
HETATM 3497 O O   . HOH D 4 .   ? 174.49500 369.46700 37.37600  1.000 37.34393  ? 735 HOH F O   1 
HETATM 3498 O O   . HOH D 4 .   ? 173.99800 376.32900 36.10200  1.000 47.65592  ? 736 HOH F O   1 
HETATM 3499 O O   . HOH D 4 .   ? 162.76600 367.75200 28.59500  1.000 24.09834  ? 737 HOH F O   1 
HETATM 3500 O O   . HOH D 4 .   ? 173.60500 366.37200 37.54400  1.000 39.63633  ? 738 HOH F O   1 
HETATM 3501 O O   . HOH D 4 .   ? 188.38000 335.72200 34.61500  1.000 31.57985  ? 739 HOH F O   1 
HETATM 3502 O O   . HOH D 4 .   ? 177.06100 336.82100 38.85600  1.000 29.37217  ? 740 HOH F O   1 
HETATM 3503 O O   . HOH D 4 .   ? 179.51200 333.34200 37.77700  1.000 31.60015  ? 741 HOH F O   1 
HETATM 3504 O O   . HOH D 4 .   ? 157.26200 348.21800 37.76000  1.000 46.34089  ? 742 HOH F O   1 
HETATM 3505 O O   . HOH D 4 .   ? 166.24400 336.49200 14.73700  1.000 42.22431  ? 743 HOH F O   1 
HETATM 3506 O O   . HOH D 4 .   ? 174.16900 332.72800 3.64900   1.000 36.35991  ? 744 HOH F O   1 
HETATM 3507 O O   . HOH D 4 .   ? 157.22700 350.78600 38.35600  1.000 41.60579  ? 745 HOH F O   1 
HETATM 3508 O O   . HOH D 4 .   ? 178.04300 325.50100 -16.34300 1.000 47.72619  ? 746 HOH F O   1 
HETATM 3509 O O   . HOH D 4 .   ? 168.17600 341.69300 23.00700  1.000 37.71084  ? 747 HOH F O   1 
HETATM 3510 O O   . HOH D 4 .   ? 181.47100 332.77000 40.30800  1.000 35.67078  ? 748 HOH F O   1 
HETATM 3511 O O   . HOH D 4 .   ? 188.16800 341.69800 39.18400  1.000 37.24221  ? 749 HOH F O   1 
HETATM 3512 O O   . HOH D 4 .   ? 177.26800 343.75200 34.04600  1.000 25.32024  ? 750 HOH F O   1 
HETATM 3513 O O   . HOH D 4 .   ? 183.38200 325.55800 19.68700  1.000 35.56199  ? 751 HOH F O   1 
HETATM 3514 O O   . HOH D 4 .   ? 172.61100 346.92300 25.56000  1.000 27.34161  ? 752 HOH F O   1 
HETATM 3515 O O   . HOH D 4 .   ? 176.93300 329.52300 36.62600  1.000 28.87133  ? 753 HOH F O   1 
HETATM 3516 O O   . HOH D 4 .   ? 164.16100 369.45200 30.44200  1.000 32.10976  ? 754 HOH F O   1 
HETATM 3517 O O   . HOH D 4 .   ? 171.76400 363.48500 36.26800  1.000 35.02038  ? 755 HOH F O   1 
HETATM 3518 O O   . HOH D 4 .   ? 169.56800 316.17300 -22.68000 1.000 58.04106  ? 756 HOH F O   1 
HETATM 3519 O O   . HOH D 4 .   ? 153.63600 361.83300 21.82400  1.000 28.66505  ? 757 HOH F O   1 
HETATM 3520 O O   . HOH D 4 .   ? 157.99700 362.95600 18.34500  1.000 30.30788  ? 758 HOH F O   1 
HETATM 3521 O O   . HOH D 4 .   ? 171.78000 328.43600 38.06500  1.000 27.06649  ? 759 HOH F O   1 
HETATM 3522 O O   . HOH D 4 .   ? 159.88300 353.60200 38.02300  1.000 30.41247  ? 760 HOH F O   1 
HETATM 3523 O O   . HOH D 4 .   ? 183.40400 331.16900 8.69000   1.000 42.15358  ? 761 HOH F O   1 
# 
