data_8W3E
# 
_entry.id   8W3E 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8W3E         pdb_00008w3e 10.2210/pdb8w3e/pdb 
WWPDB D_1000280313 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8W3E 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jiang@scripps.edu 
_pdbx_contact_author.name_first         JIANG 
_pdbx_contact_author.name_last          ZHU 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0259-7157 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lee, Y.Z.'       1 ?                   
'Stanfield, R.L.' 2 0000-0001-9521-9184 
'Wilson, I.A.'    3 0000-0002-6469-2419 
'Zhu, J.'         4 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9939 
_citation.page_last                 9939 
_citation.title                     
'Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54287-x 
_citation.pdbx_database_id_PubMed   39550381 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lee, Y.Z.'       1  0000-0002-5651-863X 
primary 'Han, J.'         2  ?                   
primary 'Zhang, Y.N.'     3  0000-0001-9053-5890 
primary 'Ward, G.'        4  ?                   
primary 'Braz Gomes, K.'  5  ?                   
primary 'Auclair, S.'     6  ?                   
primary 'Stanfield, R.L.' 7  ?                   
primary 'He, L.'          8  ?                   
primary 'Wilson, I.A.'    9  0000-0002-6469-2419 
primary 'Zhu, J.'         10 0000-0003-0259-7157 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Prefusion-stabilized RSV F protein UFCR1' 55712.688 1   ? ? ? ? 
2 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                    106.120   1   ? ? ? ? 
3 non-polymer syn 1,2-ETHANEDIOL                             62.068    1   ? ? ? ? 
4 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose   221.208   1   ? ? ? ? 
5 water       nat water                                      18.015    121 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGILPSPGMPALLSLVSLLSVLLMGCVAEQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKV
KLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL
KNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMS
NNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQA
ETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTF
SNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLAS
GYIPEAPRDGQAYVRKDGEWVLLSTFL
;
_entity_poly.pdbx_strand_id                 F 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'DI(HYDROXYETHYL)ETHER'                  PEG 
3 1,2-ETHANEDIOL                           EDO 
4 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
5 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   ILE n 
1 4   LEU n 
1 5   PRO n 
1 6   SER n 
1 7   PRO n 
1 8   GLY n 
1 9   MET n 
1 10  PRO n 
1 11  ALA n 
1 12  LEU n 
1 13  LEU n 
1 14  SER n 
1 15  LEU n 
1 16  VAL n 
1 17  SER n 
1 18  LEU n 
1 19  LEU n 
1 20  SER n 
1 21  VAL n 
1 22  LEU n 
1 23  LEU n 
1 24  MET n 
1 25  GLY n 
1 26  CYS n 
1 27  VAL n 
1 28  ALA n 
1 29  GLU n 
1 30  GLN n 
1 31  ASN n 
1 32  ILE n 
1 33  THR n 
1 34  GLU n 
1 35  GLU n 
1 36  PHE n 
1 37  TYR n 
1 38  GLN n 
1 39  SER n 
1 40  THR n 
1 41  CYS n 
1 42  SER n 
1 43  ALA n 
1 44  VAL n 
1 45  SER n 
1 46  LYS n 
1 47  GLY n 
1 48  TYR n 
1 49  LEU n 
1 50  SER n 
1 51  ALA n 
1 52  LEU n 
1 53  ARG n 
1 54  THR n 
1 55  GLY n 
1 56  TRP n 
1 57  TYR n 
1 58  THR n 
1 59  SER n 
1 60  VAL n 
1 61  ILE n 
1 62  THR n 
1 63  ILE n 
1 64  GLU n 
1 65  LEU n 
1 66  SER n 
1 67  ASN n 
1 68  ILE n 
1 69  LYS n 
1 70  GLU n 
1 71  ASN n 
1 72  LYS n 
1 73  CYS n 
1 74  ASN n 
1 75  GLY n 
1 76  THR n 
1 77  ASP n 
1 78  ALA n 
1 79  LYS n 
1 80  VAL n 
1 81  LYS n 
1 82  LEU n 
1 83  ILE n 
1 84  LYS n 
1 85  GLN n 
1 86  GLU n 
1 87  LEU n 
1 88  ASP n 
1 89  LYS n 
1 90  TYR n 
1 91  LYS n 
1 92  ASN n 
1 93  ALA n 
1 94  VAL n 
1 95  THR n 
1 96  ASP n 
1 97  LEU n 
1 98  GLN n 
1 99  LEU n 
1 100 LEU n 
1 101 MET n 
1 102 GLN n 
1 103 SER n 
1 104 THR n 
1 105 PRO n 
1 106 ALA n 
1 107 THR n 
1 108 GLY n 
1 109 SER n 
1 110 GLY n 
1 111 SER n 
1 112 ALA n 
1 113 ILE n 
1 114 ALA n 
1 115 SER n 
1 116 GLY n 
1 117 VAL n 
1 118 ALA n 
1 119 VAL n 
1 120 CYS n 
1 121 LYS n 
1 122 VAL n 
1 123 LEU n 
1 124 HIS n 
1 125 LEU n 
1 126 GLU n 
1 127 GLY n 
1 128 GLU n 
1 129 VAL n 
1 130 ASN n 
1 131 LYS n 
1 132 ILE n 
1 133 LYS n 
1 134 SER n 
1 135 ALA n 
1 136 LEU n 
1 137 LEU n 
1 138 SER n 
1 139 THR n 
1 140 ASN n 
1 141 LYS n 
1 142 ALA n 
1 143 VAL n 
1 144 VAL n 
1 145 SER n 
1 146 LEU n 
1 147 SER n 
1 148 ASN n 
1 149 GLY n 
1 150 VAL n 
1 151 SER n 
1 152 VAL n 
1 153 LEU n 
1 154 THR n 
1 155 SER n 
1 156 LYS n 
1 157 VAL n 
1 158 LEU n 
1 159 ASP n 
1 160 LEU n 
1 161 LYS n 
1 162 ASN n 
1 163 TYR n 
1 164 ILE n 
1 165 ASP n 
1 166 LYS n 
1 167 GLN n 
1 168 LEU n 
1 169 LEU n 
1 170 PRO n 
1 171 ILE n 
1 172 VAL n 
1 173 ASN n 
1 174 LYS n 
1 175 GLN n 
1 176 SER n 
1 177 CYS n 
1 178 SER n 
1 179 ILE n 
1 180 PRO n 
1 181 ASN n 
1 182 ILE n 
1 183 GLU n 
1 184 THR n 
1 185 VAL n 
1 186 ILE n 
1 187 GLU n 
1 188 PHE n 
1 189 GLN n 
1 190 GLN n 
1 191 LYS n 
1 192 ASN n 
1 193 ASN n 
1 194 ARG n 
1 195 LEU n 
1 196 LEU n 
1 197 GLU n 
1 198 ILE n 
1 199 THR n 
1 200 ARG n 
1 201 GLU n 
1 202 PHE n 
1 203 SER n 
1 204 VAL n 
1 205 ASN n 
1 206 ALA n 
1 207 GLY n 
1 208 VAL n 
1 209 THR n 
1 210 THR n 
1 211 PRO n 
1 212 VAL n 
1 213 SER n 
1 214 THR n 
1 215 TYR n 
1 216 MET n 
1 217 LEU n 
1 218 THR n 
1 219 ASN n 
1 220 SER n 
1 221 GLU n 
1 222 LEU n 
1 223 LEU n 
1 224 SER n 
1 225 LEU n 
1 226 ILE n 
1 227 ASN n 
1 228 ASP n 
1 229 MET n 
1 230 PRO n 
1 231 ILE n 
1 232 THR n 
1 233 ASN n 
1 234 ASP n 
1 235 GLN n 
1 236 LYS n 
1 237 LYS n 
1 238 LEU n 
1 239 MET n 
1 240 SER n 
1 241 ASN n 
1 242 ASN n 
1 243 VAL n 
1 244 GLN n 
1 245 ILE n 
1 246 VAL n 
1 247 ARG n 
1 248 GLN n 
1 249 GLN n 
1 250 SER n 
1 251 TYR n 
1 252 SER n 
1 253 ILE n 
1 254 MET n 
1 255 CYS n 
1 256 ILE n 
1 257 ILE n 
1 258 LYS n 
1 259 GLU n 
1 260 GLU n 
1 261 VAL n 
1 262 LEU n 
1 263 ALA n 
1 264 TYR n 
1 265 VAL n 
1 266 VAL n 
1 267 GLN n 
1 268 LEU n 
1 269 PRO n 
1 270 LEU n 
1 271 TYR n 
1 272 GLY n 
1 273 VAL n 
1 274 ILE n 
1 275 ASP n 
1 276 THR n 
1 277 PRO n 
1 278 CYS n 
1 279 TRP n 
1 280 LYS n 
1 281 LEU n 
1 282 HIS n 
1 283 THR n 
1 284 SER n 
1 285 PRO n 
1 286 LEU n 
1 287 CYS n 
1 288 THR n 
1 289 THR n 
1 290 ASN n 
1 291 THR n 
1 292 LYS n 
1 293 GLU n 
1 294 GLY n 
1 295 SER n 
1 296 ASN n 
1 297 ILE n 
1 298 CYS n 
1 299 LEU n 
1 300 THR n 
1 301 ARG n 
1 302 THR n 
1 303 ASP n 
1 304 ARG n 
1 305 GLY n 
1 306 TRP n 
1 307 TYR n 
1 308 CYS n 
1 309 ASP n 
1 310 ASN n 
1 311 ALA n 
1 312 GLY n 
1 313 SER n 
1 314 VAL n 
1 315 SER n 
1 316 PHE n 
1 317 PHE n 
1 318 PRO n 
1 319 GLN n 
1 320 ALA n 
1 321 GLU n 
1 322 THR n 
1 323 CYS n 
1 324 LYS n 
1 325 VAL n 
1 326 GLN n 
1 327 SER n 
1 328 ASN n 
1 329 ARG n 
1 330 VAL n 
1 331 PHE n 
1 332 CYS n 
1 333 ASP n 
1 334 THR n 
1 335 MET n 
1 336 ASN n 
1 337 SER n 
1 338 LEU n 
1 339 THR n 
1 340 LEU n 
1 341 PRO n 
1 342 SER n 
1 343 GLU n 
1 344 VAL n 
1 345 ASN n 
1 346 LEU n 
1 347 CYS n 
1 348 ASN n 
1 349 VAL n 
1 350 ASP n 
1 351 ILE n 
1 352 PHE n 
1 353 ASN n 
1 354 PRO n 
1 355 LYS n 
1 356 TYR n 
1 357 ASP n 
1 358 CYS n 
1 359 LYS n 
1 360 ILE n 
1 361 MET n 
1 362 THR n 
1 363 SER n 
1 364 LYS n 
1 365 THR n 
1 366 ASP n 
1 367 VAL n 
1 368 SER n 
1 369 SER n 
1 370 SER n 
1 371 VAL n 
1 372 ILE n 
1 373 THR n 
1 374 SER n 
1 375 LEU n 
1 376 GLY n 
1 377 ALA n 
1 378 ILE n 
1 379 VAL n 
1 380 SER n 
1 381 CYS n 
1 382 TYR n 
1 383 GLY n 
1 384 LYS n 
1 385 THR n 
1 386 LYS n 
1 387 CYS n 
1 388 THR n 
1 389 ALA n 
1 390 SER n 
1 391 ASN n 
1 392 LYS n 
1 393 ASN n 
1 394 ARG n 
1 395 GLY n 
1 396 ILE n 
1 397 ILE n 
1 398 LYS n 
1 399 THR n 
1 400 PHE n 
1 401 SER n 
1 402 ASN n 
1 403 GLY n 
1 404 CYS n 
1 405 ASP n 
1 406 TYR n 
1 407 VAL n 
1 408 SER n 
1 409 ASN n 
1 410 LYS n 
1 411 GLY n 
1 412 VAL n 
1 413 ASP n 
1 414 THR n 
1 415 VAL n 
1 416 SER n 
1 417 VAL n 
1 418 GLY n 
1 419 ASN n 
1 420 THR n 
1 421 LEU n 
1 422 TYR n 
1 423 TYR n 
1 424 VAL n 
1 425 ASN n 
1 426 LYS n 
1 427 GLN n 
1 428 GLU n 
1 429 GLY n 
1 430 LYS n 
1 431 SER n 
1 432 LEU n 
1 433 TYR n 
1 434 VAL n 
1 435 LYS n 
1 436 GLY n 
1 437 GLU n 
1 438 PRO n 
1 439 ILE n 
1 440 ILE n 
1 441 ASN n 
1 442 PHE n 
1 443 TYR n 
1 444 ASP n 
1 445 PRO n 
1 446 LEU n 
1 447 VAL n 
1 448 PHE n 
1 449 PRO n 
1 450 SER n 
1 451 ASP n 
1 452 GLU n 
1 453 PHE n 
1 454 ASP n 
1 455 ALA n 
1 456 SER n 
1 457 ILE n 
1 458 SER n 
1 459 GLN n 
1 460 VAL n 
1 461 ASN n 
1 462 GLU n 
1 463 LYS n 
1 464 ILE n 
1 465 ASN n 
1 466 GLN n 
1 467 SER n 
1 468 LEU n 
1 469 ALA n 
1 470 PHE n 
1 471 ILE n 
1 472 ARG n 
1 473 LYS n 
1 474 SER n 
1 475 ASP n 
1 476 GLU n 
1 477 LEU n 
1 478 LEU n 
1 479 ALA n 
1 480 SER n 
1 481 GLY n 
1 482 TYR n 
1 483 ILE n 
1 484 PRO n 
1 485 GLU n 
1 486 ALA n 
1 487 PRO n 
1 488 ARG n 
1 489 ASP n 
1 490 GLY n 
1 491 GLN n 
1 492 ALA n 
1 493 TYR n 
1 494 VAL n 
1 495 ARG n 
1 496 LYS n 
1 497 ASP n 
1 498 GLY n 
1 499 GLU n 
1 500 TRP n 
1 501 VAL n 
1 502 LEU n 
1 503 LEU n 
1 504 SER n 
1 505 THR n 
1 506 PHE n 
1 507 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   507 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Human respiratory syncytial virus A2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11259 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
EDO non-polymer                  . 1,2-ETHANEDIOL                           'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PEG non-polymer                  . 'DI(HYDROXYETHYL)ETHER'                  ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -3  ?   ?   ?   F . n 
A 1 2   GLY 2   -2  ?   ?   ?   F . n 
A 1 3   ILE 3   -1  ?   ?   ?   F . n 
A 1 4   LEU 4   0   ?   ?   ?   F . n 
A 1 5   PRO 5   1   ?   ?   ?   F . n 
A 1 6   SER 6   2   ?   ?   ?   F . n 
A 1 7   PRO 7   3   ?   ?   ?   F . n 
A 1 8   GLY 8   4   ?   ?   ?   F . n 
A 1 9   MET 9   5   ?   ?   ?   F . n 
A 1 10  PRO 10  6   ?   ?   ?   F . n 
A 1 11  ALA 11  7   ?   ?   ?   F . n 
A 1 12  LEU 12  8   ?   ?   ?   F . n 
A 1 13  LEU 13  9   ?   ?   ?   F . n 
A 1 14  SER 14  10  ?   ?   ?   F . n 
A 1 15  LEU 15  11  ?   ?   ?   F . n 
A 1 16  VAL 16  12  ?   ?   ?   F . n 
A 1 17  SER 17  13  ?   ?   ?   F . n 
A 1 18  LEU 18  14  ?   ?   ?   F . n 
A 1 19  LEU 19  15  ?   ?   ?   F . n 
A 1 20  SER 20  16  ?   ?   ?   F . n 
A 1 21  VAL 21  17  ?   ?   ?   F . n 
A 1 22  LEU 22  18  ?   ?   ?   F . n 
A 1 23  LEU 23  19  ?   ?   ?   F . n 
A 1 24  MET 24  20  ?   ?   ?   F . n 
A 1 25  GLY 25  21  ?   ?   ?   F . n 
A 1 26  CYS 26  22  ?   ?   ?   F . n 
A 1 27  VAL 27  23  ?   ?   ?   F . n 
A 1 28  ALA 28  24  ?   ?   ?   F . n 
A 1 29  GLU 29  25  ?   ?   ?   F . n 
A 1 30  GLN 30  26  26  GLN GLN F . n 
A 1 31  ASN 31  27  27  ASN ASN F . n 
A 1 32  ILE 32  28  28  ILE ILE F . n 
A 1 33  THR 33  29  29  THR THR F . n 
A 1 34  GLU 34  30  30  GLU GLU F . n 
A 1 35  GLU 35  31  31  GLU GLU F . n 
A 1 36  PHE 36  32  32  PHE PHE F . n 
A 1 37  TYR 37  33  33  TYR TYR F . n 
A 1 38  GLN 38  34  34  GLN GLN F . n 
A 1 39  SER 39  35  35  SER SER F . n 
A 1 40  THR 40  36  36  THR THR F . n 
A 1 41  CYS 41  37  37  CYS CYS F . n 
A 1 42  SER 42  38  38  SER SER F . n 
A 1 43  ALA 43  39  39  ALA ALA F . n 
A 1 44  VAL 44  40  40  VAL VAL F . n 
A 1 45  SER 45  41  41  SER SER F . n 
A 1 46  LYS 46  42  42  LYS LYS F . n 
A 1 47  GLY 47  43  43  GLY GLY F . n 
A 1 48  TYR 48  44  44  TYR TYR F . n 
A 1 49  LEU 49  45  45  LEU LEU F . n 
A 1 50  SER 50  46  46  SER SER F . n 
A 1 51  ALA 51  47  47  ALA ALA F . n 
A 1 52  LEU 52  48  48  LEU LEU F . n 
A 1 53  ARG 53  49  49  ARG ARG F . n 
A 1 54  THR 54  50  50  THR THR F . n 
A 1 55  GLY 55  51  51  GLY GLY F . n 
A 1 56  TRP 56  52  52  TRP TRP F . n 
A 1 57  TYR 57  53  53  TYR TYR F . n 
A 1 58  THR 58  54  54  THR THR F . n 
A 1 59  SER 59  55  55  SER SER F . n 
A 1 60  VAL 60  56  56  VAL VAL F . n 
A 1 61  ILE 61  57  57  ILE ILE F . n 
A 1 62  THR 62  58  58  THR THR F . n 
A 1 63  ILE 63  59  59  ILE ILE F . n 
A 1 64  GLU 64  60  60  GLU GLU F . n 
A 1 65  LEU 65  61  61  LEU LEU F . n 
A 1 66  SER 66  62  62  SER SER F . n 
A 1 67  ASN 67  63  63  ASN ASN F . n 
A 1 68  ILE 68  64  64  ILE ILE F . n 
A 1 69  LYS 69  65  65  LYS LYS F . n 
A 1 70  GLU 70  66  66  GLU GLU F . n 
A 1 71  ASN 71  67  67  ASN ASN F . n 
A 1 72  LYS 72  68  68  LYS LYS F . n 
A 1 73  CYS 73  69  69  CYS CYS F . n 
A 1 74  ASN 74  70  70  ASN ASN F . n 
A 1 75  GLY 75  71  71  GLY GLY F . n 
A 1 76  THR 76  72  72  THR THR F . n 
A 1 77  ASP 77  73  73  ASP ASP F . n 
A 1 78  ALA 78  74  74  ALA ALA F . n 
A 1 79  LYS 79  75  75  LYS LYS F . n 
A 1 80  VAL 80  76  76  VAL VAL F . n 
A 1 81  LYS 81  77  77  LYS LYS F . n 
A 1 82  LEU 82  78  78  LEU LEU F . n 
A 1 83  ILE 83  79  79  ILE ILE F . n 
A 1 84  LYS 84  80  80  LYS LYS F . n 
A 1 85  GLN 85  81  81  GLN GLN F . n 
A 1 86  GLU 86  82  82  GLU GLU F . n 
A 1 87  LEU 87  83  83  LEU LEU F . n 
A 1 88  ASP 88  84  84  ASP ASP F . n 
A 1 89  LYS 89  85  85  LYS LYS F . n 
A 1 90  TYR 90  86  86  TYR TYR F . n 
A 1 91  LYS 91  87  87  LYS LYS F . n 
A 1 92  ASN 92  88  88  ASN ASN F . n 
A 1 93  ALA 93  89  89  ALA ALA F . n 
A 1 94  VAL 94  90  90  VAL VAL F . n 
A 1 95  THR 95  91  91  THR THR F . n 
A 1 96  ASP 96  92  92  ASP ASP F . n 
A 1 97  LEU 97  93  93  LEU LEU F . n 
A 1 98  GLN 98  94  94  GLN GLN F . n 
A 1 99  LEU 99  95  95  LEU LEU F . n 
A 1 100 LEU 100 96  96  LEU LEU F . n 
A 1 101 MET 101 97  97  MET MET F . n 
A 1 102 GLN 102 98  98  GLN GLN F . n 
A 1 103 SER 103 99  99  SER SER F . n 
A 1 104 THR 104 100 100 THR THR F . n 
A 1 105 PRO 105 101 101 PRO PRO F . n 
A 1 106 ALA 106 102 102 ALA ALA F . n 
A 1 107 THR 107 103 103 THR THR F . n 
A 1 108 GLY 108 143 143 GLY GLY F . n 
A 1 109 SER 109 144 144 SER SER F . n 
A 1 110 GLY 110 145 145 GLY GLY F . n 
A 1 111 SER 111 146 146 SER SER F . n 
A 1 112 ALA 112 147 147 ALA ALA F . n 
A 1 113 ILE 113 148 148 ILE ILE F . n 
A 1 114 ALA 114 149 149 ALA ALA F . n 
A 1 115 SER 115 150 150 SER SER F . n 
A 1 116 GLY 116 151 151 GLY GLY F . n 
A 1 117 VAL 117 152 152 VAL VAL F . n 
A 1 118 ALA 118 153 153 ALA ALA F . n 
A 1 119 VAL 119 154 154 VAL VAL F . n 
A 1 120 CYS 120 155 155 CYS CYS F . n 
A 1 121 LYS 121 156 156 LYS LYS F . n 
A 1 122 VAL 122 157 157 VAL VAL F . n 
A 1 123 LEU 123 158 158 LEU LEU F . n 
A 1 124 HIS 124 159 159 HIS HIS F . n 
A 1 125 LEU 125 160 160 LEU LEU F . n 
A 1 126 GLU 126 161 161 GLU GLU F . n 
A 1 127 GLY 127 162 162 GLY GLY F . n 
A 1 128 GLU 128 163 163 GLU GLU F . n 
A 1 129 VAL 129 164 164 VAL VAL F . n 
A 1 130 ASN 130 165 165 ASN ASN F . n 
A 1 131 LYS 131 166 166 LYS LYS F . n 
A 1 132 ILE 132 167 167 ILE ILE F . n 
A 1 133 LYS 133 168 168 LYS LYS F . n 
A 1 134 SER 134 169 169 SER SER F . n 
A 1 135 ALA 135 170 170 ALA ALA F . n 
A 1 136 LEU 136 171 171 LEU LEU F . n 
A 1 137 LEU 137 172 172 LEU LEU F . n 
A 1 138 SER 138 173 173 SER SER F . n 
A 1 139 THR 139 174 174 THR THR F . n 
A 1 140 ASN 140 175 175 ASN ASN F . n 
A 1 141 LYS 141 176 176 LYS LYS F . n 
A 1 142 ALA 142 177 177 ALA ALA F . n 
A 1 143 VAL 143 178 178 VAL VAL F . n 
A 1 144 VAL 144 179 179 VAL VAL F . n 
A 1 145 SER 145 180 180 SER SER F . n 
A 1 146 LEU 146 181 181 LEU LEU F . n 
A 1 147 SER 147 182 182 SER SER F . n 
A 1 148 ASN 148 183 183 ASN ASN F . n 
A 1 149 GLY 149 184 184 GLY GLY F . n 
A 1 150 VAL 150 185 185 VAL VAL F . n 
A 1 151 SER 151 186 186 SER SER F . n 
A 1 152 VAL 152 187 187 VAL VAL F . n 
A 1 153 LEU 153 188 188 LEU LEU F . n 
A 1 154 THR 154 189 189 THR THR F . n 
A 1 155 SER 155 190 190 SER SER F . n 
A 1 156 LYS 156 191 191 LYS LYS F . n 
A 1 157 VAL 157 192 192 VAL VAL F . n 
A 1 158 LEU 158 193 193 LEU LEU F . n 
A 1 159 ASP 159 194 194 ASP ASP F . n 
A 1 160 LEU 160 195 195 LEU LEU F . n 
A 1 161 LYS 161 196 196 LYS LYS F . n 
A 1 162 ASN 162 197 197 ASN ASN F . n 
A 1 163 TYR 163 198 198 TYR TYR F . n 
A 1 164 ILE 164 199 199 ILE ILE F . n 
A 1 165 ASP 165 200 200 ASP ASP F . n 
A 1 166 LYS 166 201 201 LYS LYS F . n 
A 1 167 GLN 167 202 202 GLN GLN F . n 
A 1 168 LEU 168 203 203 LEU LEU F . n 
A 1 169 LEU 169 204 204 LEU LEU F . n 
A 1 170 PRO 170 205 205 PRO PRO F . n 
A 1 171 ILE 171 206 206 ILE ILE F . n 
A 1 172 VAL 172 207 207 VAL VAL F . n 
A 1 173 ASN 173 208 208 ASN ASN F . n 
A 1 174 LYS 174 209 209 LYS LYS F . n 
A 1 175 GLN 175 210 210 GLN GLN F . n 
A 1 176 SER 176 211 211 SER SER F . n 
A 1 177 CYS 177 212 212 CYS CYS F . n 
A 1 178 SER 178 213 213 SER SER F . n 
A 1 179 ILE 179 214 214 ILE ILE F . n 
A 1 180 PRO 180 215 215 PRO PRO F . n 
A 1 181 ASN 181 216 216 ASN ASN F . n 
A 1 182 ILE 182 217 217 ILE ILE F . n 
A 1 183 GLU 183 218 218 GLU GLU F . n 
A 1 184 THR 184 219 219 THR THR F . n 
A 1 185 VAL 185 220 220 VAL VAL F . n 
A 1 186 ILE 186 221 221 ILE ILE F . n 
A 1 187 GLU 187 222 222 GLU GLU F . n 
A 1 188 PHE 188 223 223 PHE PHE F . n 
A 1 189 GLN 189 224 224 GLN GLN F . n 
A 1 190 GLN 190 225 225 GLN GLN F . n 
A 1 191 LYS 191 226 226 LYS LYS F . n 
A 1 192 ASN 192 227 227 ASN ASN F . n 
A 1 193 ASN 193 228 228 ASN ASN F . n 
A 1 194 ARG 194 229 229 ARG ARG F . n 
A 1 195 LEU 195 230 230 LEU LEU F . n 
A 1 196 LEU 196 231 231 LEU LEU F . n 
A 1 197 GLU 197 232 232 GLU GLU F . n 
A 1 198 ILE 198 233 233 ILE ILE F . n 
A 1 199 THR 199 234 234 THR THR F . n 
A 1 200 ARG 200 235 235 ARG ARG F . n 
A 1 201 GLU 201 236 236 GLU GLU F . n 
A 1 202 PHE 202 237 237 PHE PHE F . n 
A 1 203 SER 203 238 238 SER SER F . n 
A 1 204 VAL 204 239 239 VAL VAL F . n 
A 1 205 ASN 205 240 240 ASN ASN F . n 
A 1 206 ALA 206 241 241 ALA ALA F . n 
A 1 207 GLY 207 242 242 GLY GLY F . n 
A 1 208 VAL 208 243 243 VAL VAL F . n 
A 1 209 THR 209 244 244 THR THR F . n 
A 1 210 THR 210 245 245 THR THR F . n 
A 1 211 PRO 211 246 246 PRO PRO F . n 
A 1 212 VAL 212 247 247 VAL VAL F . n 
A 1 213 SER 213 248 248 SER SER F . n 
A 1 214 THR 214 249 249 THR THR F . n 
A 1 215 TYR 215 250 250 TYR TYR F . n 
A 1 216 MET 216 251 251 MET MET F . n 
A 1 217 LEU 217 252 252 LEU LEU F . n 
A 1 218 THR 218 253 253 THR THR F . n 
A 1 219 ASN 219 254 254 ASN ASN F . n 
A 1 220 SER 220 255 255 SER SER F . n 
A 1 221 GLU 221 256 256 GLU GLU F . n 
A 1 222 LEU 222 257 257 LEU LEU F . n 
A 1 223 LEU 223 258 258 LEU LEU F . n 
A 1 224 SER 224 259 259 SER SER F . n 
A 1 225 LEU 225 260 260 LEU LEU F . n 
A 1 226 ILE 226 261 261 ILE ILE F . n 
A 1 227 ASN 227 262 262 ASN ASN F . n 
A 1 228 ASP 228 263 263 ASP ASP F . n 
A 1 229 MET 229 264 264 MET MET F . n 
A 1 230 PRO 230 265 265 PRO PRO F . n 
A 1 231 ILE 231 266 266 ILE ILE F . n 
A 1 232 THR 232 267 267 THR THR F . n 
A 1 233 ASN 233 268 268 ASN ASN F . n 
A 1 234 ASP 234 269 269 ASP ASP F . n 
A 1 235 GLN 235 270 270 GLN GLN F . n 
A 1 236 LYS 236 271 271 LYS LYS F . n 
A 1 237 LYS 237 272 272 LYS LYS F . n 
A 1 238 LEU 238 273 273 LEU LEU F . n 
A 1 239 MET 239 274 274 MET MET F . n 
A 1 240 SER 240 275 275 SER SER F . n 
A 1 241 ASN 241 276 276 ASN ASN F . n 
A 1 242 ASN 242 277 277 ASN ASN F . n 
A 1 243 VAL 243 278 278 VAL VAL F . n 
A 1 244 GLN 244 279 279 GLN GLN F . n 
A 1 245 ILE 245 280 280 ILE ILE F . n 
A 1 246 VAL 246 281 281 VAL VAL F . n 
A 1 247 ARG 247 282 282 ARG ARG F . n 
A 1 248 GLN 248 283 283 GLN GLN F . n 
A 1 249 GLN 249 284 284 GLN GLN F . n 
A 1 250 SER 250 285 285 SER SER F . n 
A 1 251 TYR 251 286 286 TYR TYR F . n 
A 1 252 SER 252 287 287 SER SER F . n 
A 1 253 ILE 253 288 288 ILE ILE F . n 
A 1 254 MET 254 289 289 MET MET F . n 
A 1 255 CYS 255 290 290 CYS CYS F . n 
A 1 256 ILE 256 291 291 ILE ILE F . n 
A 1 257 ILE 257 292 292 ILE ILE F . n 
A 1 258 LYS 258 293 293 LYS LYS F . n 
A 1 259 GLU 259 294 294 GLU GLU F . n 
A 1 260 GLU 260 295 295 GLU GLU F . n 
A 1 261 VAL 261 296 296 VAL VAL F . n 
A 1 262 LEU 262 297 297 LEU LEU F . n 
A 1 263 ALA 263 298 298 ALA ALA F . n 
A 1 264 TYR 264 299 299 TYR TYR F . n 
A 1 265 VAL 265 300 300 VAL VAL F . n 
A 1 266 VAL 266 301 301 VAL VAL F . n 
A 1 267 GLN 267 302 302 GLN GLN F . n 
A 1 268 LEU 268 303 303 LEU LEU F . n 
A 1 269 PRO 269 304 304 PRO PRO F . n 
A 1 270 LEU 270 305 305 LEU LEU F . n 
A 1 271 TYR 271 306 306 TYR TYR F . n 
A 1 272 GLY 272 307 307 GLY GLY F . n 
A 1 273 VAL 273 308 308 VAL VAL F . n 
A 1 274 ILE 274 309 309 ILE ILE F . n 
A 1 275 ASP 275 310 310 ASP ASP F . n 
A 1 276 THR 276 311 311 THR THR F . n 
A 1 277 PRO 277 312 312 PRO PRO F . n 
A 1 278 CYS 278 313 313 CYS CYS F . n 
A 1 279 TRP 279 314 314 TRP TRP F . n 
A 1 280 LYS 280 315 315 LYS LYS F . n 
A 1 281 LEU 281 316 316 LEU LEU F . n 
A 1 282 HIS 282 317 317 HIS HIS F . n 
A 1 283 THR 283 318 318 THR THR F . n 
A 1 284 SER 284 319 319 SER SER F . n 
A 1 285 PRO 285 320 320 PRO PRO F . n 
A 1 286 LEU 286 321 321 LEU LEU F . n 
A 1 287 CYS 287 322 322 CYS CYS F . n 
A 1 288 THR 288 323 323 THR THR F . n 
A 1 289 THR 289 324 324 THR THR F . n 
A 1 290 ASN 290 325 325 ASN ASN F . n 
A 1 291 THR 291 326 326 THR THR F . n 
A 1 292 LYS 292 327 327 LYS LYS F . n 
A 1 293 GLU 293 328 328 GLU GLU F . n 
A 1 294 GLY 294 329 329 GLY GLY F . n 
A 1 295 SER 295 330 330 SER SER F . n 
A 1 296 ASN 296 331 331 ASN ASN F . n 
A 1 297 ILE 297 332 332 ILE ILE F . n 
A 1 298 CYS 298 333 333 CYS CYS F . n 
A 1 299 LEU 299 334 334 LEU LEU F . n 
A 1 300 THR 300 335 335 THR THR F . n 
A 1 301 ARG 301 336 336 ARG ARG F . n 
A 1 302 THR 302 337 337 THR THR F . n 
A 1 303 ASP 303 338 338 ASP ASP F . n 
A 1 304 ARG 304 339 339 ARG ARG F . n 
A 1 305 GLY 305 340 340 GLY GLY F . n 
A 1 306 TRP 306 341 341 TRP TRP F . n 
A 1 307 TYR 307 342 342 TYR TYR F . n 
A 1 308 CYS 308 343 343 CYS CYS F . n 
A 1 309 ASP 309 344 344 ASP ASP F . n 
A 1 310 ASN 310 345 345 ASN ASN F . n 
A 1 311 ALA 311 346 346 ALA ALA F . n 
A 1 312 GLY 312 347 347 GLY GLY F . n 
A 1 313 SER 313 348 348 SER SER F . n 
A 1 314 VAL 314 349 349 VAL VAL F . n 
A 1 315 SER 315 350 350 SER SER F . n 
A 1 316 PHE 316 351 351 PHE PHE F . n 
A 1 317 PHE 317 352 352 PHE PHE F . n 
A 1 318 PRO 318 353 353 PRO PRO F . n 
A 1 319 GLN 319 354 354 GLN GLN F . n 
A 1 320 ALA 320 355 355 ALA ALA F . n 
A 1 321 GLU 321 356 356 GLU GLU F . n 
A 1 322 THR 322 357 357 THR THR F . n 
A 1 323 CYS 323 358 358 CYS CYS F . n 
A 1 324 LYS 324 359 359 LYS LYS F . n 
A 1 325 VAL 325 360 360 VAL VAL F . n 
A 1 326 GLN 326 361 361 GLN GLN F . n 
A 1 327 SER 327 362 362 SER SER F . n 
A 1 328 ASN 328 363 363 ASN ASN F . n 
A 1 329 ARG 329 364 364 ARG ARG F . n 
A 1 330 VAL 330 365 365 VAL VAL F . n 
A 1 331 PHE 331 366 366 PHE PHE F . n 
A 1 332 CYS 332 367 367 CYS CYS F . n 
A 1 333 ASP 333 368 368 ASP ASP F . n 
A 1 334 THR 334 369 369 THR THR F . n 
A 1 335 MET 335 370 370 MET MET F . n 
A 1 336 ASN 336 371 371 ASN ASN F . n 
A 1 337 SER 337 372 372 SER SER F . n 
A 1 338 LEU 338 373 373 LEU LEU F . n 
A 1 339 THR 339 374 374 THR THR F . n 
A 1 340 LEU 340 375 375 LEU LEU F . n 
A 1 341 PRO 341 376 376 PRO PRO F . n 
A 1 342 SER 342 377 377 SER SER F . n 
A 1 343 GLU 343 378 378 GLU GLU F . n 
A 1 344 VAL 344 379 379 VAL VAL F . n 
A 1 345 ASN 345 380 380 ASN ASN F . n 
A 1 346 LEU 346 381 381 LEU LEU F . n 
A 1 347 CYS 347 382 382 CYS CYS F . n 
A 1 348 ASN 348 383 383 ASN ASN F . n 
A 1 349 VAL 349 384 384 VAL VAL F . n 
A 1 350 ASP 350 385 385 ASP ASP F . n 
A 1 351 ILE 351 386 386 ILE ILE F . n 
A 1 352 PHE 352 387 387 PHE PHE F . n 
A 1 353 ASN 353 388 388 ASN ASN F . n 
A 1 354 PRO 354 389 389 PRO PRO F . n 
A 1 355 LYS 355 390 390 LYS LYS F . n 
A 1 356 TYR 356 391 391 TYR TYR F . n 
A 1 357 ASP 357 392 392 ASP ASP F . n 
A 1 358 CYS 358 393 393 CYS CYS F . n 
A 1 359 LYS 359 394 394 LYS LYS F . n 
A 1 360 ILE 360 395 395 ILE ILE F . n 
A 1 361 MET 361 396 396 MET MET F . n 
A 1 362 THR 362 397 397 THR THR F . n 
A 1 363 SER 363 398 398 SER SER F . n 
A 1 364 LYS 364 399 399 LYS LYS F . n 
A 1 365 THR 365 400 400 THR THR F . n 
A 1 366 ASP 366 401 401 ASP ASP F . n 
A 1 367 VAL 367 402 402 VAL VAL F . n 
A 1 368 SER 368 403 403 SER SER F . n 
A 1 369 SER 369 404 404 SER SER F . n 
A 1 370 SER 370 405 405 SER SER F . n 
A 1 371 VAL 371 406 406 VAL VAL F . n 
A 1 372 ILE 372 407 407 ILE ILE F . n 
A 1 373 THR 373 408 408 THR THR F . n 
A 1 374 SER 374 409 409 SER SER F . n 
A 1 375 LEU 375 410 410 LEU LEU F . n 
A 1 376 GLY 376 411 411 GLY GLY F . n 
A 1 377 ALA 377 412 412 ALA ALA F . n 
A 1 378 ILE 378 413 413 ILE ILE F . n 
A 1 379 VAL 379 414 414 VAL VAL F . n 
A 1 380 SER 380 415 415 SER SER F . n 
A 1 381 CYS 381 416 416 CYS CYS F . n 
A 1 382 TYR 382 417 417 TYR TYR F . n 
A 1 383 GLY 383 418 418 GLY GLY F . n 
A 1 384 LYS 384 419 419 LYS LYS F . n 
A 1 385 THR 385 420 420 THR THR F . n 
A 1 386 LYS 386 421 421 LYS LYS F . n 
A 1 387 CYS 387 422 422 CYS CYS F . n 
A 1 388 THR 388 423 423 THR THR F . n 
A 1 389 ALA 389 424 424 ALA ALA F . n 
A 1 390 SER 390 425 425 SER SER F . n 
A 1 391 ASN 391 426 426 ASN ASN F . n 
A 1 392 LYS 392 427 427 LYS LYS F . n 
A 1 393 ASN 393 428 428 ASN ASN F . n 
A 1 394 ARG 394 429 429 ARG ARG F . n 
A 1 395 GLY 395 430 430 GLY GLY F . n 
A 1 396 ILE 396 431 431 ILE ILE F . n 
A 1 397 ILE 397 432 432 ILE ILE F . n 
A 1 398 LYS 398 433 433 LYS LYS F . n 
A 1 399 THR 399 434 434 THR THR F . n 
A 1 400 PHE 400 435 435 PHE PHE F . n 
A 1 401 SER 401 436 436 SER SER F . n 
A 1 402 ASN 402 437 437 ASN ASN F . n 
A 1 403 GLY 403 438 438 GLY GLY F . n 
A 1 404 CYS 404 439 439 CYS CYS F . n 
A 1 405 ASP 405 440 440 ASP ASP F . n 
A 1 406 TYR 406 441 441 TYR TYR F . n 
A 1 407 VAL 407 442 442 VAL VAL F . n 
A 1 408 SER 408 443 443 SER SER F . n 
A 1 409 ASN 409 444 444 ASN ASN F . n 
A 1 410 LYS 410 445 445 LYS LYS F . n 
A 1 411 GLY 411 446 446 GLY GLY F . n 
A 1 412 VAL 412 447 447 VAL VAL F . n 
A 1 413 ASP 413 448 448 ASP ASP F . n 
A 1 414 THR 414 449 449 THR THR F . n 
A 1 415 VAL 415 450 450 VAL VAL F . n 
A 1 416 SER 416 451 451 SER SER F . n 
A 1 417 VAL 417 452 452 VAL VAL F . n 
A 1 418 GLY 418 453 453 GLY GLY F . n 
A 1 419 ASN 419 454 454 ASN ASN F . n 
A 1 420 THR 420 455 455 THR THR F . n 
A 1 421 LEU 421 456 456 LEU LEU F . n 
A 1 422 TYR 422 457 457 TYR TYR F . n 
A 1 423 TYR 423 458 458 TYR TYR F . n 
A 1 424 VAL 424 459 459 VAL VAL F . n 
A 1 425 ASN 425 460 460 ASN ASN F . n 
A 1 426 LYS 426 461 461 LYS LYS F . n 
A 1 427 GLN 427 462 462 GLN GLN F . n 
A 1 428 GLU 428 463 463 GLU GLU F . n 
A 1 429 GLY 429 464 464 GLY GLY F . n 
A 1 430 LYS 430 465 465 LYS LYS F . n 
A 1 431 SER 431 466 466 SER SER F . n 
A 1 432 LEU 432 467 467 LEU LEU F . n 
A 1 433 TYR 433 468 468 TYR TYR F . n 
A 1 434 VAL 434 469 469 VAL VAL F . n 
A 1 435 LYS 435 470 470 LYS LYS F . n 
A 1 436 GLY 436 471 471 GLY GLY F . n 
A 1 437 GLU 437 472 472 GLU GLU F . n 
A 1 438 PRO 438 473 473 PRO PRO F . n 
A 1 439 ILE 439 474 474 ILE ILE F . n 
A 1 440 ILE 440 475 475 ILE ILE F . n 
A 1 441 ASN 441 476 476 ASN ASN F . n 
A 1 442 PHE 442 477 477 PHE PHE F . n 
A 1 443 TYR 443 478 478 TYR TYR F . n 
A 1 444 ASP 444 479 479 ASP ASP F . n 
A 1 445 PRO 445 480 480 PRO PRO F . n 
A 1 446 LEU 446 481 481 LEU LEU F . n 
A 1 447 VAL 447 482 482 VAL VAL F . n 
A 1 448 PHE 448 483 483 PHE PHE F . n 
A 1 449 PRO 449 484 484 PRO PRO F . n 
A 1 450 SER 450 485 485 SER SER F . n 
A 1 451 ASP 451 486 486 ASP ASP F . n 
A 1 452 GLU 452 487 487 GLU GLU F . n 
A 1 453 PHE 453 488 488 PHE PHE F . n 
A 1 454 ASP 454 489 489 ASP ASP F . n 
A 1 455 ALA 455 490 490 ALA ALA F . n 
A 1 456 SER 456 491 491 SER SER F . n 
A 1 457 ILE 457 492 492 ILE ILE F . n 
A 1 458 SER 458 493 493 SER SER F . n 
A 1 459 GLN 459 494 494 GLN GLN F . n 
A 1 460 VAL 460 495 495 VAL VAL F . n 
A 1 461 ASN 461 496 496 ASN ASN F . n 
A 1 462 GLU 462 497 497 GLU GLU F . n 
A 1 463 LYS 463 498 498 LYS LYS F . n 
A 1 464 ILE 464 499 499 ILE ILE F . n 
A 1 465 ASN 465 500 500 ASN ASN F . n 
A 1 466 GLN 466 501 501 GLN GLN F . n 
A 1 467 SER 467 502 502 SER SER F . n 
A 1 468 LEU 468 503 503 LEU LEU F . n 
A 1 469 ALA 469 504 504 ALA ALA F . n 
A 1 470 PHE 470 505 505 PHE PHE F . n 
A 1 471 ILE 471 506 506 ILE ILE F . n 
A 1 472 ARG 472 507 507 ARG ARG F . n 
A 1 473 LYS 473 508 508 LYS LYS F . n 
A 1 474 SER 474 509 ?   ?   ?   F . n 
A 1 475 ASP 475 510 ?   ?   ?   F . n 
A 1 476 GLU 476 511 ?   ?   ?   F . n 
A 1 477 LEU 477 512 ?   ?   ?   F . n 
A 1 478 LEU 478 513 ?   ?   ?   F . n 
A 1 479 ALA 479 514 ?   ?   ?   F . n 
A 1 480 SER 480 515 ?   ?   ?   F . n 
A 1 481 GLY 481 516 ?   ?   ?   F . n 
A 1 482 TYR 482 517 ?   ?   ?   F . n 
A 1 483 ILE 483 518 ?   ?   ?   F . n 
A 1 484 PRO 484 519 ?   ?   ?   F . n 
A 1 485 GLU 485 520 ?   ?   ?   F . n 
A 1 486 ALA 486 521 ?   ?   ?   F . n 
A 1 487 PRO 487 522 ?   ?   ?   F . n 
A 1 488 ARG 488 523 ?   ?   ?   F . n 
A 1 489 ASP 489 524 ?   ?   ?   F . n 
A 1 490 GLY 490 525 ?   ?   ?   F . n 
A 1 491 GLN 491 526 ?   ?   ?   F . n 
A 1 492 ALA 492 527 ?   ?   ?   F . n 
A 1 493 TYR 493 528 ?   ?   ?   F . n 
A 1 494 VAL 494 529 ?   ?   ?   F . n 
A 1 495 ARG 495 530 ?   ?   ?   F . n 
A 1 496 LYS 496 531 ?   ?   ?   F . n 
A 1 497 ASP 497 532 ?   ?   ?   F . n 
A 1 498 GLY 498 533 ?   ?   ?   F . n 
A 1 499 GLU 499 534 ?   ?   ?   F . n 
A 1 500 TRP 500 535 ?   ?   ?   F . n 
A 1 501 VAL 501 536 ?   ?   ?   F . n 
A 1 502 LEU 502 537 ?   ?   ?   F . n 
A 1 503 LEU 503 538 ?   ?   ?   F . n 
A 1 504 SER 504 539 ?   ?   ?   F . n 
A 1 505 THR 505 540 ?   ?   ?   F . n 
A 1 506 PHE 506 541 ?   ?   ?   F . n 
A 1 507 LEU 507 542 ?   ?   ?   F . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 PEG 1   601 544 PEG PEG F . 
C 3 EDO 1   602 545 EDO EDO F . 
D 4 NAG 1   603 546 NAG NAG F . 
E 5 HOH 1   701 38  HOH HOH F . 
E 5 HOH 2   702 30  HOH HOH F . 
E 5 HOH 3   703 116 HOH HOH F . 
E 5 HOH 4   704 60  HOH HOH F . 
E 5 HOH 5   705 23  HOH HOH F . 
E 5 HOH 6   706 66  HOH HOH F . 
E 5 HOH 7   707 80  HOH HOH F . 
E 5 HOH 8   708 85  HOH HOH F . 
E 5 HOH 9   709 111 HOH HOH F . 
E 5 HOH 10  710 39  HOH HOH F . 
E 5 HOH 11  711 34  HOH HOH F . 
E 5 HOH 12  712 1   HOH HOH F . 
E 5 HOH 13  713 89  HOH HOH F . 
E 5 HOH 14  714 49  HOH HOH F . 
E 5 HOH 15  715 99  HOH HOH F . 
E 5 HOH 16  716 29  HOH HOH F . 
E 5 HOH 17  717 51  HOH HOH F . 
E 5 HOH 18  718 41  HOH HOH F . 
E 5 HOH 19  719 102 HOH HOH F . 
E 5 HOH 20  720 4   HOH HOH F . 
E 5 HOH 21  721 72  HOH HOH F . 
E 5 HOH 22  722 48  HOH HOH F . 
E 5 HOH 23  723 81  HOH HOH F . 
E 5 HOH 24  724 71  HOH HOH F . 
E 5 HOH 25  725 10  HOH HOH F . 
E 5 HOH 26  726 84  HOH HOH F . 
E 5 HOH 27  727 76  HOH HOH F . 
E 5 HOH 28  728 64  HOH HOH F . 
E 5 HOH 29  729 12  HOH HOH F . 
E 5 HOH 30  730 7   HOH HOH F . 
E 5 HOH 31  731 54  HOH HOH F . 
E 5 HOH 32  732 79  HOH HOH F . 
E 5 HOH 33  733 40  HOH HOH F . 
E 5 HOH 34  734 35  HOH HOH F . 
E 5 HOH 35  735 73  HOH HOH F . 
E 5 HOH 36  736 56  HOH HOH F . 
E 5 HOH 37  737 33  HOH HOH F . 
E 5 HOH 38  738 93  HOH HOH F . 
E 5 HOH 39  739 57  HOH HOH F . 
E 5 HOH 40  740 63  HOH HOH F . 
E 5 HOH 41  741 75  HOH HOH F . 
E 5 HOH 42  742 11  HOH HOH F . 
E 5 HOH 43  743 18  HOH HOH F . 
E 5 HOH 44  744 16  HOH HOH F . 
E 5 HOH 45  745 27  HOH HOH F . 
E 5 HOH 46  746 24  HOH HOH F . 
E 5 HOH 47  747 70  HOH HOH F . 
E 5 HOH 48  748 46  HOH HOH F . 
E 5 HOH 49  749 5   HOH HOH F . 
E 5 HOH 50  750 74  HOH HOH F . 
E 5 HOH 51  751 44  HOH HOH F . 
E 5 HOH 52  752 37  HOH HOH F . 
E 5 HOH 53  753 25  HOH HOH F . 
E 5 HOH 54  754 2   HOH HOH F . 
E 5 HOH 55  755 21  HOH HOH F . 
E 5 HOH 56  756 47  HOH HOH F . 
E 5 HOH 57  757 83  HOH HOH F . 
E 5 HOH 58  758 8   HOH HOH F . 
E 5 HOH 59  759 59  HOH HOH F . 
E 5 HOH 60  760 115 HOH HOH F . 
E 5 HOH 61  761 62  HOH HOH F . 
E 5 HOH 62  762 114 HOH HOH F . 
E 5 HOH 63  763 14  HOH HOH F . 
E 5 HOH 64  764 112 HOH HOH F . 
E 5 HOH 65  765 106 HOH HOH F . 
E 5 HOH 66  766 100 HOH HOH F . 
E 5 HOH 67  767 3   HOH HOH F . 
E 5 HOH 68  768 22  HOH HOH F . 
E 5 HOH 69  769 36  HOH HOH F . 
E 5 HOH 70  770 101 HOH HOH F . 
E 5 HOH 71  771 6   HOH HOH F . 
E 5 HOH 72  772 17  HOH HOH F . 
E 5 HOH 73  773 108 HOH HOH F . 
E 5 HOH 74  774 9   HOH HOH F . 
E 5 HOH 75  775 42  HOH HOH F . 
E 5 HOH 76  776 69  HOH HOH F . 
E 5 HOH 77  777 50  HOH HOH F . 
E 5 HOH 78  778 28  HOH HOH F . 
E 5 HOH 79  779 31  HOH HOH F . 
E 5 HOH 80  780 97  HOH HOH F . 
E 5 HOH 81  781 61  HOH HOH F . 
E 5 HOH 82  782 87  HOH HOH F . 
E 5 HOH 83  783 103 HOH HOH F . 
E 5 HOH 84  784 107 HOH HOH F . 
E 5 HOH 85  785 52  HOH HOH F . 
E 5 HOH 86  786 94  HOH HOH F . 
E 5 HOH 87  787 109 HOH HOH F . 
E 5 HOH 88  788 91  HOH HOH F . 
E 5 HOH 89  789 110 HOH HOH F . 
E 5 HOH 90  790 88  HOH HOH F . 
E 5 HOH 91  791 58  HOH HOH F . 
E 5 HOH 92  792 15  HOH HOH F . 
E 5 HOH 93  793 55  HOH HOH F . 
E 5 HOH 94  794 98  HOH HOH F . 
E 5 HOH 95  795 92  HOH HOH F . 
E 5 HOH 96  796 19  HOH HOH F . 
E 5 HOH 97  797 20  HOH HOH F . 
E 5 HOH 98  798 45  HOH HOH F . 
E 5 HOH 99  799 113 HOH HOH F . 
E 5 HOH 100 800 43  HOH HOH F . 
E 5 HOH 101 801 26  HOH HOH F . 
E 5 HOH 102 802 13  HOH HOH F . 
E 5 HOH 103 803 90  HOH HOH F . 
E 5 HOH 104 804 120 HOH HOH F . 
E 5 HOH 105 805 96  HOH HOH F . 
E 5 HOH 106 806 95  HOH HOH F . 
E 5 HOH 107 807 117 HOH HOH F . 
E 5 HOH 108 808 67  HOH HOH F . 
E 5 HOH 109 809 118 HOH HOH F . 
E 5 HOH 110 810 78  HOH HOH F . 
E 5 HOH 111 811 53  HOH HOH F . 
E 5 HOH 112 812 104 HOH HOH F . 
E 5 HOH 113 813 77  HOH HOH F . 
E 5 HOH 114 814 82  HOH HOH F . 
E 5 HOH 115 815 68  HOH HOH F . 
E 5 HOH 116 816 86  HOH HOH F . 
E 5 HOH 117 817 65  HOH HOH F . 
E 5 HOH 118 818 105 HOH HOH F . 
E 5 HOH 119 819 32  HOH HOH F . 
E 5 HOH 120 820 121 HOH HOH F . 
E 5 HOH 121 821 119 HOH HOH F . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8W3E 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     170.033 
_cell.length_a_esd                 ? 
_cell.length_b                     170.033 
_cell.length_b_esd                 ? 
_cell.length_c                     170.033 
_cell.length_c_esd                 ? 
_cell.volume                       4915861.655 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8W3E 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                213 
_symmetry.space_group_name_Hall            'P 4bd 2ab 3' 
_symmetry.space_group_name_H-M             'P 41 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8W3E 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.68 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          66.54 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M di-Sodium tartrate, 18% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-01-22 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97946 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97946 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          44.35 
_reflns.entry_id                                       8W3E 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.26 
_reflns.d_resolution_low                               36.25 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     39817 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     0 
_reflns.observed_criterion_sigma_I                     -3 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                70.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          27.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.182 
_reflns.pdbx_Rpim_I_all                                0.022 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1807 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.26 
_reflns_shell.d_res_low                                     2.34 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             39803 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.0215 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  1 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.181 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               60.24 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8W3E 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.26 
_refine.ls_d_res_low                             36.25 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     39817 
_refine.ls_number_reflns_R_free                  1961 
_refine.ls_number_reflns_R_work                  37856 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.91 
_refine.ls_percent_reflns_R_free                 4.93 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2283 
_refine.ls_R_factor_R_free                       0.2528 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2270 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.8733 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2845 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.26 
_refine_hist.d_res_low                        36.25 
_refine_hist.number_atoms_solvent             121 
_refine_hist.number_atoms_total               3573 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3427 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         25 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0105  ? 3506 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.5469  ? 4751 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0862  ? 576  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0161  ? 598  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.9993 ? 1305 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.26 2.32  . . 128 2675 100.00 . . . . 0.3241 . . . . . . . . . . . 0.3641 
'X-RAY DIFFRACTION' 2.32 2.38  . . 147 2635 100.00 . . . . 0.2807 . . . . . . . . . . . 0.2953 
'X-RAY DIFFRACTION' 2.38 2.45  . . 110 2684 100.00 . . . . 0.2808 . . . . . . . . . . . 0.2726 
'X-RAY DIFFRACTION' 2.45 2.53  . . 127 2662 100.00 . . . . 0.2812 . . . . . . . . . . . 0.3111 
'X-RAY DIFFRACTION' 2.53 2.62  . . 143 2662 100.00 . . . . 0.2757 . . . . . . . . . . . 0.3165 
'X-RAY DIFFRACTION' 2.62 2.72  . . 153 2647 100.00 . . . . 0.2816 . . . . . . . . . . . 0.3465 
'X-RAY DIFFRACTION' 2.72 2.85  . . 145 2656 99.96  . . . . 0.2793 . . . . . . . . . . . 0.3584 
'X-RAY DIFFRACTION' 2.85 3.00  . . 125 2713 99.96  . . . . 0.2831 . . . . . . . . . . . 0.2884 
'X-RAY DIFFRACTION' 3.00 3.18  . . 141 2671 99.93  . . . . 0.2515 . . . . . . . . . . . 0.2840 
'X-RAY DIFFRACTION' 3.19 3.43  . . 128 2721 99.89  . . . . 0.2437 . . . . . . . . . . . 0.2515 
'X-RAY DIFFRACTION' 3.43 3.77  . . 158 2699 99.97  . . . . 0.2153 . . . . . . . . . . . 0.2402 
'X-RAY DIFFRACTION' 3.78 4.32  . . 153 2724 99.97  . . . . 0.2004 . . . . . . . . . . . 0.2191 
'X-RAY DIFFRACTION' 4.32 5.44  . . 164 2763 99.93  . . . . 0.1784 . . . . . . . . . . . 0.2327 
'X-RAY DIFFRACTION' 5.44 36.25 . . 139 2944 99.39  . . . . 0.1972 . . . . . . . . . . . 0.2002 
# 
_struct.entry_id                     8W3E 
_struct.title                        'Crystal structure of prefusion-stabilized RSV F protein UFCR1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8W3E 
_struct_keywords.text            'Respiratory syncytial virus, glycoprotein, prefusion vaccine, stabilized, viral protein' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8W3E 
_struct_ref.pdbx_db_accession          8W3E 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8W3E 
_struct_ref_seq.pdbx_strand_id                F 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 507 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8W3E 
_struct_ref_seq.db_align_beg                  -3 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  542 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -3 
_struct_ref_seq.pdbx_auth_seq_align_end       542 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 13040 ? 
1 MORE         -8    ? 
1 'SSA (A^2)'  55430 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000 0.0000000000 0.0000000000 0.0000000000    0.0000000000 1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000    
2 'crystal symmetry operation' 5_663 z+1,x+1,y-2 0.0000000000 0.0000000000 1.0000000000 170.0330000000  1.0000000000 0.0000000000 
0.0000000000 170.0330000000 0.0000000000 1.0000000000 0.0000000000 -340.0660000000 
3 'crystal symmetry operation' 9_474 y-1,z+2,x-1 0.0000000000 1.0000000000 0.0000000000 -170.0330000000 0.0000000000 0.0000000000 
1.0000000000 340.0660000000 1.0000000000 0.0000000000 0.0000000000 -170.0330000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 77  ? SER A 103 ? ASP F 73  SER F 99  1 ? 27 
HELX_P HELX_P2  AA2 SER A 109 ? HIS A 124 ? SER F 144 HIS F 159 1 ? 16 
HELX_P HELX_P3  AA3 GLY A 127 ? LEU A 136 ? GLY F 162 LEU F 171 1 ? 10 
HELX_P HELX_P4  AA4 LEU A 160 ? LEU A 168 ? LEU F 195 LEU F 203 1 ? 9  
HELX_P HELX_P5  AA5 LEU A 168 ? ASN A 173 ? LEU F 203 ASN F 208 1 ? 6  
HELX_P HELX_P6  AA6 ASN A 181 ? ASN A 205 ? ASN F 216 ASN F 240 1 ? 25 
HELX_P HELX_P7  AA7 THR A 218 ? ASP A 228 ? THR F 253 ASP F 263 1 ? 11 
HELX_P HELX_P8  AA8 THR A 232 ? ASN A 242 ? THR F 267 ASN F 277 1 ? 11 
HELX_P HELX_P9  AA9 ASN A 242 ? GLN A 249 ? ASN F 277 GLN F 284 1 ? 8  
HELX_P HELX_P10 AB1 GLN A 319 ? GLU A 321 ? GLN F 354 GLU F 356 5 ? 3  
HELX_P HELX_P11 AB2 MET A 335 ? SER A 337 ? MET F 370 SER F 372 5 ? 3  
HELX_P HELX_P12 AB3 PRO A 341 ? VAL A 349 ? PRO F 376 VAL F 384 5 ? 9  
HELX_P HELX_P13 AB4 PRO A 438 ? TYR A 443 ? PRO F 473 TYR F 478 5 ? 6  
HELX_P HELX_P14 AB5 ASP A 444 ? PHE A 448 ? ASP F 479 PHE F 483 5 ? 5  
HELX_P HELX_P15 AB6 ILE A 457 ? LYS A 473 ? ILE F 492 LYS F 508 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 41  SG  ? ? ? 1_555 A CYS 404 SG ? ? F CYS 37  F CYS 439 1_555 ? ? ? ? ? ? ? 2.011 ? ?               
disulf2 disulf ?   ? A CYS 73  SG  ? ? ? 1_555 A CYS 177 SG ? ? F CYS 69  F CYS 212 1_555 ? ? ? ? ? ? ? 2.045 ? ?               
disulf3 disulf ?   ? A CYS 120 SG  ? ? ? 1_555 A CYS 255 SG ? ? F CYS 155 F CYS 290 1_555 ? ? ? ? ? ? ? 2.070 ? ?               
disulf4 disulf ?   ? A CYS 278 SG  ? ? ? 1_555 A CYS 308 SG ? ? F CYS 313 F CYS 343 1_555 ? ? ? ? ? ? ? 2.079 ? ?               
disulf5 disulf ?   ? A CYS 287 SG  ? ? ? 1_555 A CYS 298 SG ? ? F CYS 322 F CYS 333 1_555 ? ? ? ? ? ? ? 2.057 ? ?               
disulf6 disulf ?   ? A CYS 323 SG  ? ? ? 1_555 A CYS 332 SG ? ? F CYS 358 F CYS 367 1_555 ? ? ? ? ? ? ? 2.120 ? ?               
disulf7 disulf ?   ? A CYS 347 SG  ? ? ? 1_555 A CYS 358 SG ? ? F CYS 382 F CYS 393 1_555 ? ? ? ? ? ? ? 2.075 ? ?               
disulf8 disulf ?   ? A CYS 381 SG  ? ? ? 1_555 A CYS 387 SG ? ? F CYS 416 F CYS 422 1_555 ? ? ? ? ? ? ? 2.166 ? ?               
covale1 covale one ? A ASN 465 ND2 ? ? ? 1_555 D NAG .   C1 ? ? F ASN 500 F NAG 603 1_555 ? ? ? ? ? ? ? 1.459 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG D .   ? ASN A 465 ? NAG F 603 ? 1_555 ASN F 500 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 CYS A 41  ? CYS A 404 ? CYS F 37  ? 1_555 CYS F 439 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3 CYS A 73  ? CYS A 177 ? CYS F 69  ? 1_555 CYS F 212 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4 CYS A 120 ? CYS A 255 ? CYS F 155 ? 1_555 CYS F 290 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5 CYS A 278 ? CYS A 308 ? CYS F 313 ? 1_555 CYS F 343 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6 CYS A 287 ? CYS A 298 ? CYS F 322 ? 1_555 CYS F 333 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7 CYS A 323 ? CYS A 332 ? CYS F 358 ? 1_555 CYS F 367 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8 CYS A 347 ? CYS A 358 ? CYS F 382 ? 1_555 CYS F 393 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9 CYS A 381 ? CYS A 387 ? CYS F 416 ? 1_555 CYS F 422 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          THR 
_struct_mon_prot_cis.label_seq_id           210 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           THR 
_struct_mon_prot_cis.auth_seq_id            245 
_struct_mon_prot_cis.auth_asym_id           F 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    211 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     246 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    F 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.54 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 13 ? 
AA2 ? 4  ? 
AA3 ? 3  ? 
AA4 ? 4  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA1 1  13 ? parallel      
AA1 2  4  ? parallel      
AA1 2  7  ? anti-parallel 
AA1 2  11 ? parallel      
AA1 3  4  ? anti-parallel 
AA1 5  6  ? anti-parallel 
AA1 6  7  ? anti-parallel 
AA1 7  8  ? anti-parallel 
AA1 8  9  ? anti-parallel 
AA1 9  12 ? anti-parallel 
AA1 10 11 ? anti-parallel 
AA2 1  2  ? anti-parallel 
AA2 2  3  ? anti-parallel 
AA2 3  4  ? anti-parallel 
AA3 1  2  ? anti-parallel 
AA3 2  3  ? anti-parallel 
AA4 1  2  ? anti-parallel 
AA4 2  3  ? anti-parallel 
AA4 3  4  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  THR A 33  ? TYR A 37  ? THR F 29  TYR F 33  
AA1 2  SER A 42  ? GLU A 64  ? SER F 38  GLU F 60  
AA1 3  LYS A 141 ? SER A 145 ? LYS F 176 SER F 180 
AA1 4  SER A 151 ? ASP A 159 ? SER F 186 ASP F 194 
AA1 5  VAL A 208 ? THR A 209 ? VAL F 243 THR F 244 
AA1 6  TYR A 251 ? ILE A 257 ? TYR F 286 ILE F 292 
AA1 7  VAL A 261 ? THR A 283 ? VAL F 296 THR F 318 
AA1 8  GLY A 305 ? ASN A 310 ? GLY F 340 ASN F 345 
AA1 9  SER A 313 ? PHE A 317 ? SER F 348 PHE F 352 
AA1 10 CYS A 323 ? GLN A 326 ? CYS F 358 GLN F 361 
AA1 11 ARG A 329 ? ASP A 333 ? ARG F 364 ASP F 368 
AA1 12 LEU A 338 ? LEU A 340 ? LEU F 373 LEU F 375 
AA1 13 LYS A 430 ? VAL A 434 ? LYS F 465 VAL F 469 
AA2 1  LEU A 286 ? CYS A 287 ? LEU F 321 CYS F 322 
AA2 2  CYS A 298 ? ARG A 301 ? CYS F 333 ARG F 336 
AA2 3  LYS A 359 ? SER A 363 ? LYS F 394 SER F 398 
AA2 4  ALA A 455 ? SER A 456 ? ALA F 490 SER F 491 
AA3 1  SER A 369 ? ILE A 372 ? SER F 404 ILE F 407 
AA3 2  GLY A 376 ? CYS A 381 ? GLY F 411 CYS F 416 
AA3 3  GLY A 403 ? SER A 408 ? GLY F 438 SER F 443 
AA4 1  GLY A 395 ? THR A 399 ? GLY F 430 THR F 434 
AA4 2  CYS A 387 ? ASN A 391 ? CYS F 422 ASN F 426 
AA4 3  THR A 414 ? VAL A 417 ? THR F 449 VAL F 452 
AA4 4  THR A 420 ? TYR A 423 ? THR F 455 TYR F 458 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N TYR A 37  ? N TYR F 33  O SER A 42  ? O SER F 38  
AA1 1  13 N PHE A 36  ? N PHE F 32  O VAL A 434 ? O VAL F 469 
AA1 2  4  N THR A 62  ? N THR F 58  O SER A 155 ? O SER F 190 
AA1 2  7  N ALA A 43  ? N ALA F 39  O HIS A 282 ? O HIS F 317 
AA1 2  11 N ARG A 53  ? N ARG F 49  O CYS A 332 ? O CYS F 367 
AA1 3  4  N ALA A 142 ? N ALA F 177 O THR A 154 ? O THR F 189 
AA1 5  6  N THR A 209 ? N THR F 244 O SER A 252 ? O SER F 287 
AA1 6  7  N TYR A 251 ? N TYR F 286 O GLN A 267 ? O GLN F 302 
AA1 7  8  N PRO A 277 ? N PRO F 312 O ASP A 309 ? O ASP F 344 
AA1 8  9  N CYS A 308 ? N CYS F 343 O SER A 315 ? O SER F 350 
AA1 9  12 N VAL A 314 ? N VAL F 349 O LEU A 340 ? O LEU F 375 
AA1 10 11 N LYS A 324 ? N LYS F 359 O PHE A 331 ? O PHE F 366 
AA2 1  2  N LEU A 286 ? N LEU F 321 O LEU A 299 ? O LEU F 334 
AA2 2  3  N THR A 300 ? N THR F 335 O MET A 361 ? O MET F 396 
AA2 3  4  N ILE A 360 ? N ILE F 395 O ALA A 455 ? O ALA F 490 
AA3 1  2  N SER A 369 ? N SER F 404 O SER A 380 ? O SER F 415 
AA3 2  3  N VAL A 379 ? N VAL F 414 O ASP A 405 ? O ASP F 440 
AA4 1  2  O LYS A 398 ? O LYS F 433 N ALA A 389 ? N ALA F 424 
AA4 2  3  N THR A 388 ? N THR F 423 O SER A 416 ? O SER F 451 
AA4 3  4  N VAL A 415 ? N VAL F 450 O TYR A 422 ? O TYR F 457 
# 
_pdbx_entry_details.entry_id                   8W3E 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN F 63  ? ? -80.89  39.94   
2  1 ASN F 70  ? ? -58.06  107.55  
3  1 THR F 72  ? ? -141.89 -54.10  
4  1 LEU F 171 ? ? -92.50  34.62   
5  1 CYS F 290 ? ? -95.34  -100.63 
6  1 SER F 362 ? ? 66.66   -123.75 
7  1 ASN F 371 ? ? -114.80 63.69   
8  1 SER F 398 ? ? -170.22 -174.55 
9  1 ASP F 489 ? ? -157.46 59.48   
10 1 ALA F 490 ? ? -100.67 -163.06 
# 
_pdbx_validate_main_chain_plane.id                       1 
_pdbx_validate_main_chain_plane.PDB_model_num            1 
_pdbx_validate_main_chain_plane.auth_comp_id             CYS 
_pdbx_validate_main_chain_plane.auth_asym_id             F 
_pdbx_validate_main_chain_plane.auth_seq_id              422 
_pdbx_validate_main_chain_plane.PDB_ins_code             ? 
_pdbx_validate_main_chain_plane.label_alt_id             ? 
_pdbx_validate_main_chain_plane.improper_torsion_angle   -10.28 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  x+1/4,-z+1/4,y+3/4   
3  x+3/4,z+1/4,-y+1/4   
4  z+3/4,y+1/4,-x+1/4   
5  -z+1/4,y+3/4,x+1/4   
6  -y+1/4,x+3/4,z+1/4   
7  y+1/4,-x+1/4,z+3/4   
8  z,x,y                
9  y,z,x                
10 -y+1/2,-z,x+1/2      
11 z+1/2,-x+1/2,-y      
12 -y,z+1/2,-x+1/2      
13 -z+1/2,-x,y+1/2      
14 -z,x+1/2,-y+1/2      
15 y+1/2,-z+1/2,-x      
16 x+1/2,-y+1/2,-z      
17 -x,y+1/2,-z+1/2      
18 -x+1/2,-y,z+1/2      
19 y+3/4,x+1/4,-z+1/4   
20 -y+3/4,-x+3/4,-z+3/4 
21 z+1/4,-y+1/4,x+3/4   
22 -z+3/4,-y+3/4,-x+3/4 
23 -x+1/4,z+3/4,y+1/4   
24 -x+3/4,-z+3/4,-y+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 F MET -3  ? A MET 1   
2  1 Y 1 F GLY -2  ? A GLY 2   
3  1 Y 1 F ILE -1  ? A ILE 3   
4  1 Y 1 F LEU 0   ? A LEU 4   
5  1 Y 1 F PRO 1   ? A PRO 5   
6  1 Y 1 F SER 2   ? A SER 6   
7  1 Y 1 F PRO 3   ? A PRO 7   
8  1 Y 1 F GLY 4   ? A GLY 8   
9  1 Y 1 F MET 5   ? A MET 9   
10 1 Y 1 F PRO 6   ? A PRO 10  
11 1 Y 1 F ALA 7   ? A ALA 11  
12 1 Y 1 F LEU 8   ? A LEU 12  
13 1 Y 1 F LEU 9   ? A LEU 13  
14 1 Y 1 F SER 10  ? A SER 14  
15 1 Y 1 F LEU 11  ? A LEU 15  
16 1 Y 1 F VAL 12  ? A VAL 16  
17 1 Y 1 F SER 13  ? A SER 17  
18 1 Y 1 F LEU 14  ? A LEU 18  
19 1 Y 1 F LEU 15  ? A LEU 19  
20 1 Y 1 F SER 16  ? A SER 20  
21 1 Y 1 F VAL 17  ? A VAL 21  
22 1 Y 1 F LEU 18  ? A LEU 22  
23 1 Y 1 F LEU 19  ? A LEU 23  
24 1 Y 1 F MET 20  ? A MET 24  
25 1 Y 1 F GLY 21  ? A GLY 25  
26 1 Y 1 F CYS 22  ? A CYS 26  
27 1 Y 1 F VAL 23  ? A VAL 27  
28 1 Y 1 F ALA 24  ? A ALA 28  
29 1 Y 1 F GLU 25  ? A GLU 29  
30 1 Y 1 F SER 509 ? A SER 474 
31 1 Y 1 F ASP 510 ? A ASP 475 
32 1 Y 1 F GLU 511 ? A GLU 476 
33 1 Y 1 F LEU 512 ? A LEU 477 
34 1 Y 1 F LEU 513 ? A LEU 478 
35 1 Y 1 F ALA 514 ? A ALA 479 
36 1 Y 1 F SER 515 ? A SER 480 
37 1 Y 1 F GLY 516 ? A GLY 481 
38 1 Y 1 F TYR 517 ? A TYR 482 
39 1 Y 1 F ILE 518 ? A ILE 483 
40 1 Y 1 F PRO 519 ? A PRO 484 
41 1 Y 1 F GLU 520 ? A GLU 485 
42 1 Y 1 F ALA 521 ? A ALA 486 
43 1 Y 1 F PRO 522 ? A PRO 487 
44 1 Y 1 F ARG 523 ? A ARG 488 
45 1 Y 1 F ASP 524 ? A ASP 489 
46 1 Y 1 F GLY 525 ? A GLY 490 
47 1 Y 1 F GLN 526 ? A GLN 491 
48 1 Y 1 F ALA 527 ? A ALA 492 
49 1 Y 1 F TYR 528 ? A TYR 493 
50 1 Y 1 F VAL 529 ? A VAL 494 
51 1 Y 1 F ARG 530 ? A ARG 495 
52 1 Y 1 F LYS 531 ? A LYS 496 
53 1 Y 1 F ASP 532 ? A ASP 497 
54 1 Y 1 F GLY 533 ? A GLY 498 
55 1 Y 1 F GLU 534 ? A GLU 499 
56 1 Y 1 F TRP 535 ? A TRP 500 
57 1 Y 1 F VAL 536 ? A VAL 501 
58 1 Y 1 F LEU 537 ? A LEU 502 
59 1 Y 1 F LEU 538 ? A LEU 503 
60 1 Y 1 F SER 539 ? A SER 504 
61 1 Y 1 F THR 540 ? A THR 505 
62 1 Y 1 F PHE 541 ? A PHE 506 
63 1 Y 1 F LEU 542 ? A LEU 507 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EDO C1   C N N 88  
EDO O1   O N N 89  
EDO C2   C N N 90  
EDO O2   O N N 91  
EDO H11  H N N 92  
EDO H12  H N N 93  
EDO HO1  H N N 94  
EDO H21  H N N 95  
EDO H22  H N N 96  
EDO HO2  H N N 97  
GLN N    N N N 98  
GLN CA   C N S 99  
GLN C    C N N 100 
GLN O    O N N 101 
GLN CB   C N N 102 
GLN CG   C N N 103 
GLN CD   C N N 104 
GLN OE1  O N N 105 
GLN NE2  N N N 106 
GLN OXT  O N N 107 
GLN H    H N N 108 
GLN H2   H N N 109 
GLN HA   H N N 110 
GLN HB2  H N N 111 
GLN HB3  H N N 112 
GLN HG2  H N N 113 
GLN HG3  H N N 114 
GLN HE21 H N N 115 
GLN HE22 H N N 116 
GLN HXT  H N N 117 
GLU N    N N N 118 
GLU CA   C N S 119 
GLU C    C N N 120 
GLU O    O N N 121 
GLU CB   C N N 122 
GLU CG   C N N 123 
GLU CD   C N N 124 
GLU OE1  O N N 125 
GLU OE2  O N N 126 
GLU OXT  O N N 127 
GLU H    H N N 128 
GLU H2   H N N 129 
GLU HA   H N N 130 
GLU HB2  H N N 131 
GLU HB3  H N N 132 
GLU HG2  H N N 133 
GLU HG3  H N N 134 
GLU HE2  H N N 135 
GLU HXT  H N N 136 
GLY N    N N N 137 
GLY CA   C N N 138 
GLY C    C N N 139 
GLY O    O N N 140 
GLY OXT  O N N 141 
GLY H    H N N 142 
GLY H2   H N N 143 
GLY HA2  H N N 144 
GLY HA3  H N N 145 
GLY HXT  H N N 146 
HIS N    N N N 147 
HIS CA   C N S 148 
HIS C    C N N 149 
HIS O    O N N 150 
HIS CB   C N N 151 
HIS CG   C Y N 152 
HIS ND1  N Y N 153 
HIS CD2  C Y N 154 
HIS CE1  C Y N 155 
HIS NE2  N Y N 156 
HIS OXT  O N N 157 
HIS H    H N N 158 
HIS H2   H N N 159 
HIS HA   H N N 160 
HIS HB2  H N N 161 
HIS HB3  H N N 162 
HIS HD1  H N N 163 
HIS HD2  H N N 164 
HIS HE1  H N N 165 
HIS HE2  H N N 166 
HIS HXT  H N N 167 
HOH O    O N N 168 
HOH H1   H N N 169 
HOH H2   H N N 170 
ILE N    N N N 171 
ILE CA   C N S 172 
ILE C    C N N 173 
ILE O    O N N 174 
ILE CB   C N S 175 
ILE CG1  C N N 176 
ILE CG2  C N N 177 
ILE CD1  C N N 178 
ILE OXT  O N N 179 
ILE H    H N N 180 
ILE H2   H N N 181 
ILE HA   H N N 182 
ILE HB   H N N 183 
ILE HG12 H N N 184 
ILE HG13 H N N 185 
ILE HG21 H N N 186 
ILE HG22 H N N 187 
ILE HG23 H N N 188 
ILE HD11 H N N 189 
ILE HD12 H N N 190 
ILE HD13 H N N 191 
ILE HXT  H N N 192 
LEU N    N N N 193 
LEU CA   C N S 194 
LEU C    C N N 195 
LEU O    O N N 196 
LEU CB   C N N 197 
LEU CG   C N N 198 
LEU CD1  C N N 199 
LEU CD2  C N N 200 
LEU OXT  O N N 201 
LEU H    H N N 202 
LEU H2   H N N 203 
LEU HA   H N N 204 
LEU HB2  H N N 205 
LEU HB3  H N N 206 
LEU HG   H N N 207 
LEU HD11 H N N 208 
LEU HD12 H N N 209 
LEU HD13 H N N 210 
LEU HD21 H N N 211 
LEU HD22 H N N 212 
LEU HD23 H N N 213 
LEU HXT  H N N 214 
LYS N    N N N 215 
LYS CA   C N S 216 
LYS C    C N N 217 
LYS O    O N N 218 
LYS CB   C N N 219 
LYS CG   C N N 220 
LYS CD   C N N 221 
LYS CE   C N N 222 
LYS NZ   N N N 223 
LYS OXT  O N N 224 
LYS H    H N N 225 
LYS H2   H N N 226 
LYS HA   H N N 227 
LYS HB2  H N N 228 
LYS HB3  H N N 229 
LYS HG2  H N N 230 
LYS HG3  H N N 231 
LYS HD2  H N N 232 
LYS HD3  H N N 233 
LYS HE2  H N N 234 
LYS HE3  H N N 235 
LYS HZ1  H N N 236 
LYS HZ2  H N N 237 
LYS HZ3  H N N 238 
LYS HXT  H N N 239 
MET N    N N N 240 
MET CA   C N S 241 
MET C    C N N 242 
MET O    O N N 243 
MET CB   C N N 244 
MET CG   C N N 245 
MET SD   S N N 246 
MET CE   C N N 247 
MET OXT  O N N 248 
MET H    H N N 249 
MET H2   H N N 250 
MET HA   H N N 251 
MET HB2  H N N 252 
MET HB3  H N N 253 
MET HG2  H N N 254 
MET HG3  H N N 255 
MET HE1  H N N 256 
MET HE2  H N N 257 
MET HE3  H N N 258 
MET HXT  H N N 259 
NAG C1   C N R 260 
NAG C2   C N R 261 
NAG C3   C N R 262 
NAG C4   C N S 263 
NAG C5   C N R 264 
NAG C6   C N N 265 
NAG C7   C N N 266 
NAG C8   C N N 267 
NAG N2   N N N 268 
NAG O1   O N N 269 
NAG O3   O N N 270 
NAG O4   O N N 271 
NAG O5   O N N 272 
NAG O6   O N N 273 
NAG O7   O N N 274 
NAG H1   H N N 275 
NAG H2   H N N 276 
NAG H3   H N N 277 
NAG H4   H N N 278 
NAG H5   H N N 279 
NAG H61  H N N 280 
NAG H62  H N N 281 
NAG H81  H N N 282 
NAG H82  H N N 283 
NAG H83  H N N 284 
NAG HN2  H N N 285 
NAG HO1  H N N 286 
NAG HO3  H N N 287 
NAG HO4  H N N 288 
NAG HO6  H N N 289 
PEG C1   C N N 290 
PEG O1   O N N 291 
PEG C2   C N N 292 
PEG O2   O N N 293 
PEG C3   C N N 294 
PEG C4   C N N 295 
PEG O4   O N N 296 
PEG H11  H N N 297 
PEG H12  H N N 298 
PEG HO1  H N N 299 
PEG H21  H N N 300 
PEG H22  H N N 301 
PEG H31  H N N 302 
PEG H32  H N N 303 
PEG H41  H N N 304 
PEG H42  H N N 305 
PEG HO4  H N N 306 
PHE N    N N N 307 
PHE CA   C N S 308 
PHE C    C N N 309 
PHE O    O N N 310 
PHE CB   C N N 311 
PHE CG   C Y N 312 
PHE CD1  C Y N 313 
PHE CD2  C Y N 314 
PHE CE1  C Y N 315 
PHE CE2  C Y N 316 
PHE CZ   C Y N 317 
PHE OXT  O N N 318 
PHE H    H N N 319 
PHE H2   H N N 320 
PHE HA   H N N 321 
PHE HB2  H N N 322 
PHE HB3  H N N 323 
PHE HD1  H N N 324 
PHE HD2  H N N 325 
PHE HE1  H N N 326 
PHE HE2  H N N 327 
PHE HZ   H N N 328 
PHE HXT  H N N 329 
PRO N    N N N 330 
PRO CA   C N S 331 
PRO C    C N N 332 
PRO O    O N N 333 
PRO CB   C N N 334 
PRO CG   C N N 335 
PRO CD   C N N 336 
PRO OXT  O N N 337 
PRO H    H N N 338 
PRO HA   H N N 339 
PRO HB2  H N N 340 
PRO HB3  H N N 341 
PRO HG2  H N N 342 
PRO HG3  H N N 343 
PRO HD2  H N N 344 
PRO HD3  H N N 345 
PRO HXT  H N N 346 
SER N    N N N 347 
SER CA   C N S 348 
SER C    C N N 349 
SER O    O N N 350 
SER CB   C N N 351 
SER OG   O N N 352 
SER OXT  O N N 353 
SER H    H N N 354 
SER H2   H N N 355 
SER HA   H N N 356 
SER HB2  H N N 357 
SER HB3  H N N 358 
SER HG   H N N 359 
SER HXT  H N N 360 
THR N    N N N 361 
THR CA   C N S 362 
THR C    C N N 363 
THR O    O N N 364 
THR CB   C N R 365 
THR OG1  O N N 366 
THR CG2  C N N 367 
THR OXT  O N N 368 
THR H    H N N 369 
THR H2   H N N 370 
THR HA   H N N 371 
THR HB   H N N 372 
THR HG1  H N N 373 
THR HG21 H N N 374 
THR HG22 H N N 375 
THR HG23 H N N 376 
THR HXT  H N N 377 
TRP N    N N N 378 
TRP CA   C N S 379 
TRP C    C N N 380 
TRP O    O N N 381 
TRP CB   C N N 382 
TRP CG   C Y N 383 
TRP CD1  C Y N 384 
TRP CD2  C Y N 385 
TRP NE1  N Y N 386 
TRP CE2  C Y N 387 
TRP CE3  C Y N 388 
TRP CZ2  C Y N 389 
TRP CZ3  C Y N 390 
TRP CH2  C Y N 391 
TRP OXT  O N N 392 
TRP H    H N N 393 
TRP H2   H N N 394 
TRP HA   H N N 395 
TRP HB2  H N N 396 
TRP HB3  H N N 397 
TRP HD1  H N N 398 
TRP HE1  H N N 399 
TRP HE3  H N N 400 
TRP HZ2  H N N 401 
TRP HZ3  H N N 402 
TRP HH2  H N N 403 
TRP HXT  H N N 404 
TYR N    N N N 405 
TYR CA   C N S 406 
TYR C    C N N 407 
TYR O    O N N 408 
TYR CB   C N N 409 
TYR CG   C Y N 410 
TYR CD1  C Y N 411 
TYR CD2  C Y N 412 
TYR CE1  C Y N 413 
TYR CE2  C Y N 414 
TYR CZ   C Y N 415 
TYR OH   O N N 416 
TYR OXT  O N N 417 
TYR H    H N N 418 
TYR H2   H N N 419 
TYR HA   H N N 420 
TYR HB2  H N N 421 
TYR HB3  H N N 422 
TYR HD1  H N N 423 
TYR HD2  H N N 424 
TYR HE1  H N N 425 
TYR HE2  H N N 426 
TYR HH   H N N 427 
TYR HXT  H N N 428 
VAL N    N N N 429 
VAL CA   C N S 430 
VAL C    C N N 431 
VAL O    O N N 432 
VAL CB   C N N 433 
VAL CG1  C N N 434 
VAL CG2  C N N 435 
VAL OXT  O N N 436 
VAL H    H N N 437 
VAL H2   H N N 438 
VAL HA   H N N 439 
VAL HB   H N N 440 
VAL HG11 H N N 441 
VAL HG12 H N N 442 
VAL HG13 H N N 443 
VAL HG21 H N N 444 
VAL HG22 H N N 445 
VAL HG23 H N N 446 
VAL HXT  H N N 447 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
NAG C1  C2   sing N N 246 
NAG C1  O1   sing N N 247 
NAG C1  O5   sing N N 248 
NAG C1  H1   sing N N 249 
NAG C2  C3   sing N N 250 
NAG C2  N2   sing N N 251 
NAG C2  H2   sing N N 252 
NAG C3  C4   sing N N 253 
NAG C3  O3   sing N N 254 
NAG C3  H3   sing N N 255 
NAG C4  C5   sing N N 256 
NAG C4  O4   sing N N 257 
NAG C4  H4   sing N N 258 
NAG C5  C6   sing N N 259 
NAG C5  O5   sing N N 260 
NAG C5  H5   sing N N 261 
NAG C6  O6   sing N N 262 
NAG C6  H61  sing N N 263 
NAG C6  H62  sing N N 264 
NAG C7  C8   sing N N 265 
NAG C7  N2   sing N N 266 
NAG C7  O7   doub N N 267 
NAG C8  H81  sing N N 268 
NAG C8  H82  sing N N 269 
NAG C8  H83  sing N N 270 
NAG N2  HN2  sing N N 271 
NAG O1  HO1  sing N N 272 
NAG O3  HO3  sing N N 273 
NAG O4  HO4  sing N N 274 
NAG O6  HO6  sing N N 275 
PEG C1  O1   sing N N 276 
PEG C1  C2   sing N N 277 
PEG C1  H11  sing N N 278 
PEG C1  H12  sing N N 279 
PEG O1  HO1  sing N N 280 
PEG C2  O2   sing N N 281 
PEG C2  H21  sing N N 282 
PEG C2  H22  sing N N 283 
PEG O2  C3   sing N N 284 
PEG C3  C4   sing N N 285 
PEG C3  H31  sing N N 286 
PEG C3  H32  sing N N 287 
PEG C4  O4   sing N N 288 
PEG C4  H41  sing N N 289 
PEG C4  H42  sing N N 290 
PEG O4  HO4  sing N N 291 
PHE N   CA   sing N N 292 
PHE N   H    sing N N 293 
PHE N   H2   sing N N 294 
PHE CA  C    sing N N 295 
PHE CA  CB   sing N N 296 
PHE CA  HA   sing N N 297 
PHE C   O    doub N N 298 
PHE C   OXT  sing N N 299 
PHE CB  CG   sing N N 300 
PHE CB  HB2  sing N N 301 
PHE CB  HB3  sing N N 302 
PHE CG  CD1  doub Y N 303 
PHE CG  CD2  sing Y N 304 
PHE CD1 CE1  sing Y N 305 
PHE CD1 HD1  sing N N 306 
PHE CD2 CE2  doub Y N 307 
PHE CD2 HD2  sing N N 308 
PHE CE1 CZ   doub Y N 309 
PHE CE1 HE1  sing N N 310 
PHE CE2 CZ   sing Y N 311 
PHE CE2 HE2  sing N N 312 
PHE CZ  HZ   sing N N 313 
PHE OXT HXT  sing N N 314 
PRO N   CA   sing N N 315 
PRO N   CD   sing N N 316 
PRO N   H    sing N N 317 
PRO CA  C    sing N N 318 
PRO CA  CB   sing N N 319 
PRO CA  HA   sing N N 320 
PRO C   O    doub N N 321 
PRO C   OXT  sing N N 322 
PRO CB  CG   sing N N 323 
PRO CB  HB2  sing N N 324 
PRO CB  HB3  sing N N 325 
PRO CG  CD   sing N N 326 
PRO CG  HG2  sing N N 327 
PRO CG  HG3  sing N N 328 
PRO CD  HD2  sing N N 329 
PRO CD  HD3  sing N N 330 
PRO OXT HXT  sing N N 331 
SER N   CA   sing N N 332 
SER N   H    sing N N 333 
SER N   H2   sing N N 334 
SER CA  C    sing N N 335 
SER CA  CB   sing N N 336 
SER CA  HA   sing N N 337 
SER C   O    doub N N 338 
SER C   OXT  sing N N 339 
SER CB  OG   sing N N 340 
SER CB  HB2  sing N N 341 
SER CB  HB3  sing N N 342 
SER OG  HG   sing N N 343 
SER OXT HXT  sing N N 344 
THR N   CA   sing N N 345 
THR N   H    sing N N 346 
THR N   H2   sing N N 347 
THR CA  C    sing N N 348 
THR CA  CB   sing N N 349 
THR CA  HA   sing N N 350 
THR C   O    doub N N 351 
THR C   OXT  sing N N 352 
THR CB  OG1  sing N N 353 
THR CB  CG2  sing N N 354 
THR CB  HB   sing N N 355 
THR OG1 HG1  sing N N 356 
THR CG2 HG21 sing N N 357 
THR CG2 HG22 sing N N 358 
THR CG2 HG23 sing N N 359 
THR OXT HXT  sing N N 360 
TRP N   CA   sing N N 361 
TRP N   H    sing N N 362 
TRP N   H2   sing N N 363 
TRP CA  C    sing N N 364 
TRP CA  CB   sing N N 365 
TRP CA  HA   sing N N 366 
TRP C   O    doub N N 367 
TRP C   OXT  sing N N 368 
TRP CB  CG   sing N N 369 
TRP CB  HB2  sing N N 370 
TRP CB  HB3  sing N N 371 
TRP CG  CD1  doub Y N 372 
TRP CG  CD2  sing Y N 373 
TRP CD1 NE1  sing Y N 374 
TRP CD1 HD1  sing N N 375 
TRP CD2 CE2  doub Y N 376 
TRP CD2 CE3  sing Y N 377 
TRP NE1 CE2  sing Y N 378 
TRP NE1 HE1  sing N N 379 
TRP CE2 CZ2  sing Y N 380 
TRP CE3 CZ3  doub Y N 381 
TRP CE3 HE3  sing N N 382 
TRP CZ2 CH2  doub Y N 383 
TRP CZ2 HZ2  sing N N 384 
TRP CZ3 CH2  sing Y N 385 
TRP CZ3 HZ3  sing N N 386 
TRP CH2 HH2  sing N N 387 
TRP OXT HXT  sing N N 388 
TYR N   CA   sing N N 389 
TYR N   H    sing N N 390 
TYR N   H2   sing N N 391 
TYR CA  C    sing N N 392 
TYR CA  CB   sing N N 393 
TYR CA  HA   sing N N 394 
TYR C   O    doub N N 395 
TYR C   OXT  sing N N 396 
TYR CB  CG   sing N N 397 
TYR CB  HB2  sing N N 398 
TYR CB  HB3  sing N N 399 
TYR CG  CD1  doub Y N 400 
TYR CG  CD2  sing Y N 401 
TYR CD1 CE1  sing Y N 402 
TYR CD1 HD1  sing N N 403 
TYR CD2 CE2  doub Y N 404 
TYR CD2 HD2  sing N N 405 
TYR CE1 CZ   doub Y N 406 
TYR CE1 HE1  sing N N 407 
TYR CE2 CZ   sing Y N 408 
TYR CE2 HE2  sing N N 409 
TYR CZ  OH   sing N N 410 
TYR OH  HH   sing N N 411 
TYR OXT HXT  sing N N 412 
VAL N   CA   sing N N 413 
VAL N   H    sing N N 414 
VAL N   H2   sing N N 415 
VAL CA  C    sing N N 416 
VAL CA  CB   sing N N 417 
VAL CA  HA   sing N N 418 
VAL C   O    doub N N 419 
VAL C   OXT  sing N N 420 
VAL CB  CG1  sing N N 421 
VAL CB  CG2  sing N N 422 
VAL CB  HB   sing N N 423 
VAL CG1 HG11 sing N N 424 
VAL CG1 HG12 sing N N 425 
VAL CG1 HG13 sing N N 426 
VAL CG2 HG21 sing N N 427 
VAL CG2 HG22 sing N N 428 
VAL CG2 HG23 sing N N 429 
VAL OXT HXT  sing N N 430 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5K6I 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 41 3 2' 
_space_group.name_Hall        'P 4bd 2ab 3' 
_space_group.IT_number        213 
_space_group.crystal_system   cubic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8W3E 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005881 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005881 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005881 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 30  ? 163.99800 337.41100 34.83200  1.000 68.32349  ? 26  GLN F N   1 
ATOM   2    C CA  . GLN A 1 30  ? 162.59800 337.56000 34.45200  1.000 64.05184  ? 26  GLN F CA  1 
ATOM   3    C C   . GLN A 1 30  ? 162.12000 338.96100 34.79500  1.000 60.57056  ? 26  GLN F C   1 
ATOM   4    O O   . GLN A 1 30  ? 161.36400 339.53800 34.01900  1.000 59.78478  ? 26  GLN F O   1 
ATOM   5    C CB  . GLN A 1 30  ? 161.70500 336.49900 35.11300  1.000 68.91132  ? 26  GLN F CB  1 
ATOM   6    C CG  . GLN A 1 30  ? 160.23200 336.73600 34.83800  1.000 74.71607  ? 26  GLN F CG  1 
ATOM   7    C CD  . GLN A 1 30  ? 159.43800 335.46500 34.77900  1.000 83.29626  ? 26  GLN F CD  1 
ATOM   8    O OE1 . GLN A 1 30  ? 159.99000 334.38900 34.53700  1.000 90.11449  ? 26  GLN F OE1 1 
ATOM   9    N NE2 . GLN A 1 30  ? 158.13000 335.57200 34.99500  1.000 84.82293  ? 26  GLN F NE2 1 
ATOM   10   N N   . ASN A 1 31  ? 162.46700 339.48000 35.97900  1.000 55.81918  ? 27  ASN F N   1 
ATOM   11   C CA  . ASN A 1 31  ? 162.04500 340.82300 36.33900  1.000 55.42469  ? 27  ASN F CA  1 
ATOM   12   C C   . ASN A 1 31  ? 163.17900 341.76700 35.90700  1.000 56.55237  ? 27  ASN F C   1 
ATOM   13   O O   . ASN A 1 31  ? 164.25600 341.77300 36.52500  1.000 45.79092  ? 27  ASN F O   1 
ATOM   14   C CB  . ASN A 1 31  ? 161.86400 340.86700 37.85900  1.000 59.69835  ? 27  ASN F CB  1 
ATOM   15   C CG  . ASN A 1 31  ? 160.65100 340.05800 38.33600  1.000 68.80493  ? 27  ASN F CG  1 
ATOM   16   O OD1 . ASN A 1 31  ? 159.78400 339.69000 37.53700  1.000 65.06619  ? 27  ASN F OD1 1 
ATOM   17   N ND2 . ASN A 1 31  ? 160.65800 339.67300 39.62000  1.000 63.76356  ? 27  ASN F ND2 1 
ATOM   18   N N   . ILE A 1 32  ? 162.89300 342.65800 34.95700  1.000 51.70131  ? 28  ILE F N   1 
ATOM   19   C CA  . ILE A 1 32  ? 163.85900 343.65100 34.48600  1.000 43.46339  ? 28  ILE F CA  1 
ATOM   20   C C   . ILE A 1 32  ? 163.84800 344.87400 35.39700  1.000 44.19600  ? 28  ILE F C   1 
ATOM   21   O O   . ILE A 1 32  ? 162.78300 345.43300 35.66200  1.000 45.09476  ? 28  ILE F O   1 
ATOM   22   C CB  . ILE A 1 32  ? 163.60300 344.03600 33.02900  1.000 46.68087  ? 28  ILE F CB  1 
ATOM   23   C CG1 . ILE A 1 32  ? 163.69900 342.79000 32.14900  1.000 46.02637  ? 28  ILE F CG1 1 
ATOM   24   C CG2 . ILE A 1 32  ? 164.70200 345.02700 32.58000  1.000 44.46909  ? 28  ILE F CG2 1 
ATOM   25   C CD1 . ILE A 1 32  ? 164.92200 341.91000 32.41200  1.000 46.09557  ? 28  ILE F CD1 1 
ATOM   26   N N   . THR A 1 33  ? 165.00600 345.29200 35.90600  1.000 38.45841  ? 29  THR F N   1 
ATOM   27   C CA  . THR A 1 33  ? 165.00200 346.48400 36.74200  1.000 36.57841  ? 29  THR F CA  1 
ATOM   28   C C   . THR A 1 33  ? 166.04400 347.45400 36.20400  1.000 40.41908  ? 29  THR F C   1 
ATOM   29   O O   . THR A 1 33  ? 166.87400 347.09700 35.37200  1.000 37.92321  ? 29  THR F O   1 
ATOM   30   C CB  . THR A 1 33  ? 165.32500 346.16800 38.19500  1.000 43.57431  ? 29  THR F CB  1 
ATOM   31   O OG1 . THR A 1 33  ? 166.58700 345.50900 38.23500  1.000 42.36792  ? 29  THR F OG1 1 
ATOM   32   C CG2 . THR A 1 33  ? 164.26700 345.22300 38.79000  1.000 44.65855  ? 29  THR F CG2 1 
ATOM   33   N N   . GLU A 1 34  ? 165.95200 348.71100 36.62200  1.000 38.75343  ? 30  GLU F N   1 
ATOM   34   C CA  . GLU A 1 34  ? 166.89000 349.71400 36.15200  1.000 38.76864  ? 30  GLU F CA  1 
ATOM   35   C C   . GLU A 1 34  ? 167.28200 350.61600 37.29700  1.000 37.54320  ? 30  GLU F C   1 
ATOM   36   O O   . GLU A 1 34  ? 166.45200 350.96200 38.12400  1.000 39.45964  ? 30  GLU F O   1 
ATOM   37   C CB  . GLU A 1 34  ? 166.31400 350.53100 35.00600  1.000 37.81870  ? 30  GLU F CB  1 
ATOM   38   C CG  . GLU A 1 34  ? 167.34900 351.23500 34.18700  1.000 34.85907  ? 30  GLU F CG  1 
ATOM   39   C CD  . GLU A 1 34  ? 166.84100 351.56300 32.79400  1.000 35.59502  ? 30  GLU F CD  1 
ATOM   40   O OE1 . GLU A 1 34  ? 166.22700 352.63700 32.59700  1.000 36.55709  ? 30  GLU F OE1 1 
ATOM   41   O OE2 . GLU A 1 34  ? 167.05600 350.75200 31.88500  1.000 36.67243  ? 30  GLU F OE2 1 
ATOM   42   N N   . GLU A 1 35  ? 168.46800 351.18800 37.19400  1.000 37.28682  ? 31  GLU F N   1 
ATOM   43   C CA  . GLU A 1 35  ? 168.98400 352.11000 38.19700  1.000 36.31756  ? 31  GLU F CA  1 
ATOM   44   C C   . GLU A 1 35  ? 169.66300 353.25400 37.47700  1.000 36.67317  ? 31  GLU F C   1 
ATOM   45   O O   . GLU A 1 35  ? 170.47500 353.00100 36.58000  1.000 36.41384  ? 31  GLU F O   1 
ATOM   46   C CB  . GLU A 1 35  ? 169.98300 351.45400 39.15300  1.000 39.07968  ? 31  GLU F CB  1 
ATOM   47   C CG  . GLU A 1 35  ? 169.36700 350.50500 40.18300  1.000 46.86882  ? 31  GLU F CG  1 
ATOM   48   C CD  . GLU A 1 35  ? 170.41300 349.78000 41.05200  1.000 50.30976  ? 31  GLU F CD  1 
ATOM   49   O OE1 . GLU A 1 35  ? 171.61900 350.11000 40.98400  1.000 49.66292  ? 31  GLU F OE1 1 
ATOM   50   O OE2 . GLU A 1 35  ? 170.01800 348.87200 41.81500  1.000 63.41041  ? 31  GLU F OE2 1 
ATOM   51   N N   . PHE A 1 36  ? 169.13600 354.46600 37.65900  1.000 34.12152  ? 32  PHE F N   1 
ATOM   52   C CA  . PHE A 1 36  ? 169.75800 355.66900 37.12400  1.000 32.04830  ? 32  PHE F CA  1 
ATOM   53   C C   . PHE A 1 36  ? 170.62500 356.33700 38.18100  1.000 36.54523  ? 32  PHE F C   1 
ATOM   54   O O   . PHE A 1 36  ? 170.16000 356.60100 39.29000  1.000 33.65795  ? 32  PHE F O   1 
ATOM   55   C CB  . PHE A 1 36  ? 168.72700 356.66400 36.59900  1.000 33.15339  ? 32  PHE F CB  1 
ATOM   56   C CG  . PHE A 1 36  ? 169.33000 358.01200 36.25300  1.000 35.69622  ? 32  PHE F CG  1 
ATOM   57   C CD1 . PHE A 1 36  ? 170.06500 358.19900 35.08300  1.000 32.28804  ? 32  PHE F CD1 1 
ATOM   58   C CD2 . PHE A 1 36  ? 169.11300 359.10900 37.08300  1.000 32.30565  ? 32  PHE F CD2 1 
ATOM   59   C CE1 . PHE A 1 36  ? 170.62900 359.44400 34.78000  1.000 33.49603  ? 32  PHE F CE1 1 
ATOM   60   C CE2 . PHE A 1 36  ? 169.64700 360.37800 36.75700  1.000 31.82909  ? 32  PHE F CE2 1 
ATOM   61   C CZ  . PHE A 1 36  ? 170.40700 360.53200 35.60800  1.000 31.44157  ? 32  PHE F CZ  1 
ATOM   62   N N   . TYR A 1 37  ? 171.87600 356.68000 37.82100  1.000 34.69993  ? 33  TYR F N   1 
ATOM   63   C CA  . TYR A 1 37  ? 172.77900 357.29600 38.78700  1.000 35.46391  ? 33  TYR F CA  1 
ATOM   64   C C   . TYR A 1 37  ? 172.88700 358.77000 38.42200  1.000 35.47247  ? 33  TYR F C   1 
ATOM   65   O O   . TYR A 1 37  ? 173.60900 359.15000 37.49100  1.000 35.03990  ? 33  TYR F O   1 
ATOM   66   C CB  . TYR A 1 37  ? 174.16100 356.63400 38.80700  1.000 35.06505  ? 33  TYR F CB  1 
ATOM   67   C CG  . TYR A 1 37  ? 173.96500 355.17600 38.97500  1.000 35.92834  ? 33  TYR F CG  1 
ATOM   68   C CD1 . TYR A 1 37  ? 173.65900 354.62900 40.20900  1.000 38.90725  ? 33  TYR F CD1 1 
ATOM   69   C CD2 . TYR A 1 37  ? 174.25500 354.32000 37.91900  1.000 36.02961  ? 33  TYR F CD2 1 
ATOM   70   C CE1 . TYR A 1 37  ? 173.47600 353.28100 40.35200  1.000 39.91974  ? 33  TYR F CE1 1 
ATOM   71   C CE2 . TYR A 1 37  ? 174.10600 352.95600 38.05500  1.000 42.38559  ? 33  TYR F CE2 1 
ATOM   72   C CZ  . TYR A 1 37  ? 173.71800 352.44300 39.28400  1.000 42.24573  ? 33  TYR F CZ  1 
ATOM   73   O OH  . TYR A 1 37  ? 173.54800 351.08300 39.42300  1.000 49.65232  ? 33  TYR F OH  1 
ATOM   74   N N   . GLN A 1 38  ? 172.21500 359.60800 39.19800  1.000 34.27426  ? 34  GLN F N   1 
ATOM   75   C CA  . GLN A 1 38  ? 172.27000 361.02900 38.93100  1.000 32.82939  ? 34  GLN F CA  1 
ATOM   76   C C   . GLN A 1 38  ? 173.68400 361.57800 39.04700  1.000 34.90197  ? 34  GLN F C   1 
ATOM   77   O O   . GLN A 1 38  ? 174.03900 362.53000 38.33700  1.000 34.74137  ? 34  GLN F O   1 
ATOM   78   C CB  . GLN A 1 38  ? 171.30500 361.75000 39.88800  1.000 34.89318  ? 34  GLN F CB  1 
ATOM   79   C CG  . GLN A 1 38  ? 171.30100 363.26500 39.76800  1.000 32.32284  ? 34  GLN F CG  1 
ATOM   80   C CD  . GLN A 1 38  ? 170.39400 363.94400 40.80700  1.000 39.77641  ? 34  GLN F CD  1 
ATOM   81   O OE1 . GLN A 1 38  ? 170.21000 363.44300 41.90400  1.000 39.43718  ? 34  GLN F OE1 1 
ATOM   82   N NE2 . GLN A 1 38  ? 169.79700 365.07800 40.42700  1.000 40.72909  ? 34  GLN F NE2 1 
ATOM   83   N N   . SER A 1 39  ? 174.52600 360.96000 39.86700  1.000 32.65019  ? 35  SER F N   1 
ATOM   84   C CA  . SER A 1 39  ? 175.87600 361.49200 40.08000  1.000 35.35835  ? 35  SER F CA  1 
ATOM   85   C C   . SER A 1 39  ? 176.78200 361.32600 38.86200  1.000 33.05434  ? 35  SER F C   1 
ATOM   86   O O   . SER A 1 39  ? 177.75300 362.08000 38.72300  1.000 31.66208  ? 35  SER F O   1 
ATOM   87   C CB  . SER A 1 39  ? 176.53400 360.81800 41.28000  1.000 38.10547  ? 35  SER F CB  1 
ATOM   88   O OG  . SER A 1 39  ? 176.63900 359.42600 41.03700  1.000 40.64807  ? 35  SER F OG  1 
ATOM   89   N N   . THR A 1 40  ? 176.59100 360.27000 38.06900  1.000 30.07231  ? 36  THR F N   1 
ATOM   90   C CA  . THR A 1 40  ? 177.46700 359.99300 36.92800  1.000 33.44247  ? 36  THR F CA  1 
ATOM   91   C C   . THR A 1 40  ? 176.74200 360.01200 35.58800  1.000 32.00175  ? 36  THR F C   1 
ATOM   92   O O   . THR A 1 40  ? 177.33800 359.62500 34.57200  1.000 34.67574  ? 36  THR F O   1 
ATOM   93   C CB  . THR A 1 40  ? 178.18300 358.65400 37.08400  1.000 31.17758  ? 36  THR F CB  1 
ATOM   94   O OG1 . THR A 1 40  ? 177.22100 357.61400 37.29700  1.000 27.09578  ? 36  THR F OG1 1 
ATOM   95   C CG2 . THR A 1 40  ? 179.06500 358.77800 38.32600  1.000 31.59171  ? 36  THR F CG2 1 
ATOM   96   N N   . CYS A 1 41  ? 175.45700 360.34100 35.55900  1.000 31.62692  ? 37  CYS F N   1 
ATOM   97   C CA  . CYS A 1 41  ? 174.70700 360.39800 34.29900  1.000 30.35062  ? 37  CYS F CA  1 
ATOM   98   C C   . CYS A 1 41  ? 174.78500 359.06500 33.54200  1.000 30.93850  ? 37  CYS F C   1 
ATOM   99   O O   . CYS A 1 41  ? 175.11400 359.01700 32.34400  1.000 30.22613  ? 37  CYS F O   1 
ATOM   100  C CB  . CYS A 1 41  ? 175.22700 361.55000 33.43000  1.000 28.08604  ? 37  CYS F CB  1 
ATOM   101  S SG  . CYS A 1 41  ? 174.12000 361.93400 32.00700  1.000 35.88792  ? 37  CYS F SG  1 
ATOM   102  N N   . SER A 1 42  ? 174.50700 357.97000 34.26400  1.000 28.55212  ? 38  SER F N   1 
ATOM   103  C CA  . SER A 1 42  ? 174.58900 356.62200 33.72200  1.000 31.87719  ? 38  SER F CA  1 
ATOM   104  C C   . SER A 1 42  ? 173.45800 355.81000 34.33400  1.000 32.75801  ? 38  SER F C   1 
ATOM   105  O O   . SER A 1 42  ? 172.82900 356.24400 35.29100  1.000 29.76466  ? 38  SER F O   1 
ATOM   106  C CB  . SER A 1 42  ? 175.93600 355.96000 34.01300  1.000 27.75149  ? 38  SER F CB  1 
ATOM   107  O OG  . SER A 1 42  ? 176.26100 356.04800 35.38300  1.000 30.46173  ? 38  SER F OG  1 
ATOM   108  N N   . ALA A 1 43  ? 173.05200 354.76500 33.63300  1.000 29.18087  ? 39  ALA F N   1 
ATOM   109  C CA  . ALA A 1 43  ? 171.99300 353.85600 34.06100  1.000 28.24413  ? 39  ALA F CA  1 
ATOM   110  C C   . ALA A 1 43  ? 172.41900 352.41800 33.83100  1.000 30.87749  ? 39  ALA F C   1 
ATOM   111  O O   . ALA A 1 43  ? 173.20400 352.14300 32.92900  1.000 30.74608  ? 39  ALA F O   1 
ATOM   112  C CB  . ALA A 1 43  ? 170.65500 354.12600 33.34800  1.000 32.42497  ? 39  ALA F CB  1 
ATOM   113  N N   . VAL A 1 44  ? 171.94600 351.50600 34.67000  1.000 34.88251  ? 40  VAL F N   1 
ATOM   114  C CA  . VAL A 1 44  ? 172.22700 350.07800 34.53100  1.000 34.65495  ? 40  VAL F CA  1 
ATOM   115  C C   . VAL A 1 44  ? 170.91000 349.31300 34.48300  1.000 34.85322  ? 40  VAL F C   1 
ATOM   116  O O   . VAL A 1 44  ? 170.03900 349.50800 35.33600  1.000 36.30205  ? 40  VAL F O   1 
ATOM   117  C CB  . VAL A 1 44  ? 173.14200 349.52200 35.63500  1.000 39.45113  ? 40  VAL F CB  1 
ATOM   118  C CG1 . VAL A 1 44  ? 173.33900 348.06600 35.38300  1.000 37.45472  ? 40  VAL F CG1 1 
ATOM   119  C CG2 . VAL A 1 44  ? 174.53000 350.12700 35.46100  1.000 36.49511  ? 40  VAL F CG2 1 
ATOM   120  N N   . SER A 1 45  ? 170.71700 348.56400 33.40000  1.000 35.79686  ? 41  SER F N   1 
ATOM   121  C CA  . SER A 1 45  ? 169.54400 347.71900 33.18100  1.000 39.47876  ? 41  SER F CA  1 
ATOM   122  C C   . SER A 1 45  ? 169.93600 346.30000 33.61500  1.000 38.23261  ? 41  SER F C   1 
ATOM   123  O O   . SER A 1 45  ? 170.81800 345.69300 32.98700  1.000 34.80208  ? 41  SER F O   1 
ATOM   124  C CB  . SER A 1 45  ? 169.16200 347.71200 31.70300  1.000 34.79101  ? 41  SER F CB  1 
ATOM   125  O OG  . SER A 1 45  ? 168.91300 349.00900 31.18400  1.000 39.89138  ? 41  SER F OG  1 
ATOM   126  N N   . LYS A 1 46  ? 169.34000 345.81000 34.71000  1.000 40.73118  ? 42  LYS F N   1 
ATOM   127  C CA  . LYS A 1 46  ? 169.58900 344.50600 35.33300  1.000 44.46315  ? 42  LYS F CA  1 
ATOM   128  C C   . LYS A 1 46  ? 168.48100 343.47900 35.05200  1.000 44.08621  ? 42  LYS F C   1 
ATOM   129  O O   . LYS A 1 46  ? 167.33100 343.81900 34.73400  1.000 41.85869  ? 42  LYS F O   1 
ATOM   130  C CB  . LYS A 1 46  ? 169.74400 344.70300 36.85300  1.000 40.01314  ? 42  LYS F CB  1 
ATOM   131  C CG  . LYS A 1 46  ? 170.95200 345.53500 37.17300  1.000 49.72901  ? 42  LYS F CG  1 
ATOM   132  C CD  . LYS A 1 46  ? 171.11600 345.90700 38.64000  1.000 57.74128  ? 42  LYS F CD  1 
ATOM   133  C CE  . LYS A 1 46  ? 170.56700 344.91800 39.61200  1.000 58.48030  ? 42  LYS F CE  1 
ATOM   134  N NZ  . LYS A 1 46  ? 171.33700 345.09200 40.88400  1.000 67.65206  ? 42  LYS F NZ  1 
ATOM   135  N N   . GLY A 1 47  ? 168.79200 342.21200 35.38300  1.000 42.53744  ? 43  GLY F N   1 
ATOM   136  C CA  . GLY A 1 47  ? 167.83700 341.11200 35.32400  1.000 35.42026  ? 43  GLY F CA  1 
ATOM   137  C C   . GLY A 1 47  ? 167.94100 340.22200 34.11000  1.000 40.85258  ? 43  GLY F C   1 
ATOM   138  O O   . GLY A 1 47  ? 167.15200 339.28700 33.98700  1.000 38.94809  ? 43  GLY F O   1 
ATOM   139  N N   . TYR A 1 48  ? 168.90500 340.46800 33.22400  1.000 39.51177  ? 44  TYR F N   1 
ATOM   140  C CA  . TYR A 1 48  ? 169.07200 339.70300 31.99100  1.000 38.26171  ? 44  TYR F CA  1 
ATOM   141  C C   . TYR A 1 48  ? 169.87700 338.42900 32.28000  1.000 40.42765  ? 44  TYR F C   1 
ATOM   142  O O   . TYR A 1 48  ? 170.56200 338.34000 33.31100  1.000 35.54330  ? 44  TYR F O   1 
ATOM   143  C CB  . TYR A 1 48  ? 169.76100 340.54800 30.92200  1.000 40.51042  ? 44  TYR F CB  1 
ATOM   144  C CG  . TYR A 1 48  ? 168.90200 341.71700 30.46100  1.000 35.66821  ? 44  TYR F CG  1 
ATOM   145  C CD1 . TYR A 1 48  ? 168.92800 342.90400 31.18100  1.000 37.13695  ? 44  TYR F CD1 1 
ATOM   146  C CD2 . TYR A 1 48  ? 168.03600 341.61800 29.38200  1.000 39.56349  ? 44  TYR F CD2 1 
ATOM   147  C CE1 . TYR A 1 48  ? 168.16700 344.00500 30.81000  1.000 40.68982  ? 44  TYR F CE1 1 
ATOM   148  C CE2 . TYR A 1 48  ? 167.24600 342.71300 28.98900  1.000 39.43286  ? 44  TYR F CE2 1 
ATOM   149  C CZ  . TYR A 1 48  ? 167.32200 343.90400 29.73000  1.000 41.71368  ? 44  TYR F CZ  1 
ATOM   150  O OH  . TYR A 1 48  ? 166.59000 345.00500 29.40400  1.000 43.14435  ? 44  TYR F OH  1 
ATOM   151  N N   . LEU A 1 49  ? 169.53600 337.36100 31.57000  1.000 37.12058  ? 45  LEU F N   1 
ATOM   152  C CA  . LEU A 1 49  ? 170.22400 336.07000 31.64100  1.000 39.79546  ? 45  LEU F CA  1 
ATOM   153  C C   . LEU A 1 49  ? 171.14800 335.84600 30.43400  1.000 37.11481  ? 45  LEU F C   1 
ATOM   154  O O   . LEU A 1 49  ? 170.78600 336.17500 29.30500  1.000 35.66907  ? 45  LEU F O   1 
ATOM   155  C CB  . LEU A 1 49  ? 169.16300 334.97200 31.75700  1.000 35.19629  ? 45  LEU F CB  1 
ATOM   156  C CG  . LEU A 1 49  ? 168.29700 335.03100 33.03100  1.000 41.04393  ? 45  LEU F CG  1 
ATOM   157  C CD1 . LEU A 1 49  ? 167.24900 333.93400 32.95600  1.000 39.00411  ? 45  LEU F CD1 1 
ATOM   158  C CD2 . LEU A 1 49  ? 169.09600 334.78300 34.28900  1.000 36.81470  ? 45  LEU F CD2 1 
ATOM   159  N N   . SER A 1 50  ? 172.29900 335.20000 30.63900  1.000 34.92532  ? 46  SER F N   1 
ATOM   160  C CA  . SER A 1 50  ? 173.26600 335.08600 29.54900  1.000 34.25096  ? 46  SER F CA  1 
ATOM   161  C C   . SER A 1 50  ? 173.07500 333.84000 28.68600  1.000 36.80040  ? 46  SER F C   1 
ATOM   162  O O   . SER A 1 50  ? 172.53400 332.83900 29.13800  1.000 35.44029  ? 46  SER F O   1 
ATOM   163  C CB  . SER A 1 50  ? 174.68700 335.07100 30.10400  1.000 35.34447  ? 46  SER F CB  1 
ATOM   164  O OG  . SER A 1 50  ? 174.90900 333.92400 30.93300  1.000 37.72971  ? 46  SER F OG  1 
ATOM   165  N N   . ALA A 1 51  ? 173.53400 333.92800 27.42500  1.000 32.37842  ? 47  ALA F N   1 
ATOM   166  C CA  . ALA A 1 51  ? 173.89700 332.76500 26.62000  1.000 38.08091  ? 47  ALA F CA  1 
ATOM   167  C C   . ALA A 1 51  ? 175.06800 333.19900 25.74300  1.000 35.81342  ? 47  ALA F C   1 
ATOM   168  O O   . ALA A 1 51  ? 174.86500 333.82300 24.70200  1.000 39.10416  ? 47  ALA F O   1 
ATOM   169  C CB  . ALA A 1 51  ? 172.71800 332.31300 25.75900  1.000 39.62452  ? 47  ALA F CB  1 
ATOM   170  N N   . LEU A 1 52  ? 176.27600 332.88500 26.18600  1.000 33.79879  ? 48  LEU F N   1 
ATOM   171  C CA  . LEU A 1 52  ? 177.51400 333.28900 25.52900  1.000 29.92185  ? 48  LEU F CA  1 
ATOM   172  C C   . LEU A 1 52  ? 178.06100 332.16600 24.65100  1.000 33.44494  ? 48  LEU F C   1 
ATOM   173  O O   . LEU A 1 52  ? 178.24900 331.04800 25.12900  1.000 37.01462  ? 48  LEU F O   1 
ATOM   174  C CB  . LEU A 1 52  ? 178.55600 333.71000 26.57000  1.000 29.90474  ? 48  LEU F CB  1 
ATOM   175  C CG  . LEU A 1 52  ? 177.99900 334.74100 27.57400  1.000 32.56317  ? 48  LEU F CG  1 
ATOM   176  C CD1 . LEU A 1 52  ? 179.06100 335.25900 28.49800  1.000 28.68069  ? 48  LEU F CD1 1 
ATOM   177  C CD2 . LEU A 1 52  ? 177.32900 335.91500 26.82100  1.000 34.82057  ? 48  LEU F CD2 1 
ATOM   178  N N   . ARG A 1 53  ? 178.42000 332.46600 23.41900  1.000 35.86137  ? 49  ARG F N   1 
ATOM   179  C CA  . ARG A 1 53  ? 179.01200 331.42700 22.60400  1.000 38.91064  ? 49  ARG F CA  1 
ATOM   180  C C   . ARG A 1 53  ? 180.47400 331.22600 23.00200  1.000 41.44007  ? 49  ARG F C   1 
ATOM   181  O O   . ARG A 1 53  ? 181.28300 332.15800 22.94400  1.000 38.81021  ? 49  ARG F O   1 
ATOM   182  C CB  . ARG A 1 53  ? 178.96600 331.77700 21.11700  1.000 41.88844  ? 49  ARG F CB  1 
ATOM   183  C CG  . ARG A 1 53  ? 179.00300 330.52300 20.26200  1.000 38.72314  ? 49  ARG F CG  1 
ATOM   184  C CD  . ARG A 1 53  ? 179.85600 330.63300 19.00300  1.000 36.36802  ? 49  ARG F CD  1 
ATOM   185  N NE  . ARG A 1 53  ? 181.00100 331.53200 19.06700  1.000 41.88696  ? 49  ARG F NE  1 
ATOM   186  C CZ  . ARG A 1 53  ? 182.24300 331.13200 19.32800  1.000 44.36080  ? 49  ARG F CZ  1 
ATOM   187  N NH1 . ARG A 1 53  ? 182.51700 329.86900 19.64800  1.000 43.96449  ? 49  ARG F NH1 1 
ATOM   188  N NH2 . ARG A 1 53  ? 183.23100 332.01400 19.27700  1.000 37.34871  ? 49  ARG F NH2 1 
ATOM   189  N N   . THR A 1 54  ? 180.81100 329.98100 23.33800  1.000 37.34348  ? 50  THR F N   1 
ATOM   190  C CA  . THR A 1 54  ? 182.14400 329.56900 23.73100  1.000 39.49845  ? 50  THR F CA  1 
ATOM   191  C C   . THR A 1 54  ? 182.66700 328.42800 22.87900  1.000 47.87495  ? 50  THR F C   1 
ATOM   192  O O   . THR A 1 54  ? 183.88500 328.21600 22.85300  1.000 46.24490  ? 50  THR F O   1 
ATOM   193  C CB  . THR A 1 54  ? 182.16200 329.09400 25.18600  1.000 40.53554  ? 50  THR F CB  1 
ATOM   194  O OG1 . THR A 1 54  ? 181.30000 327.94900 25.29700  1.000 41.53940  ? 50  THR F OG1 1 
ATOM   195  C CG2 . THR A 1 54  ? 181.68200 330.20700 26.13700  1.000 34.98610  ? 50  THR F CG2 1 
ATOM   196  N N   . GLY A 1 55  ? 181.79900 327.73000 22.12100  1.000 45.22835  ? 51  GLY F N   1 
ATOM   197  C CA  . GLY A 1 55  ? 182.26900 326.64400 21.29300  1.000 41.73537  ? 51  GLY F CA  1 
ATOM   198  C C   . GLY A 1 55  ? 181.54200 326.57400 19.96300  1.000 46.90130  ? 51  GLY F C   1 
ATOM   199  O O   . GLY A 1 55  ? 180.59900 327.31400 19.68800  1.000 48.17413  ? 51  GLY F O   1 
ATOM   200  N N   . TRP A 1 56  ? 182.01300 325.66700 19.13400  1.000 48.38829  ? 52  TRP F N   1 
ATOM   201  C CA  . TRP A 1 56  ? 181.44300 325.44800 17.82000  1.000 47.79125  ? 52  TRP F CA  1 
ATOM   202  C C   . TRP A 1 56  ? 181.09300 323.97900 17.63800  1.000 53.01561  ? 52  TRP F C   1 
ATOM   203  O O   . TRP A 1 56  ? 181.85300 323.09300 18.03900  1.000 45.93736  ? 52  TRP F O   1 
ATOM   204  C CB  . TRP A 1 56  ? 182.37100 325.88100 16.70000  1.000 48.39006  ? 52  TRP F CB  1 
ATOM   205  C CG  . TRP A 1 56  ? 182.65400 327.34100 16.58900  1.000 50.05382  ? 52  TRP F CG  1 
ATOM   206  C CD1 . TRP A 1 56  ? 183.83200 327.98400 16.85100  1.000 49.12648  ? 52  TRP F CD1 1 
ATOM   207  C CD2 . TRP A 1 56  ? 181.71800 328.35500 16.22000  1.000 45.08626  ? 52  TRP F CD2 1 
ATOM   208  N NE1 . TRP A 1 56  ? 183.69800 329.32500 16.60400  1.000 47.08096  ? 52  TRP F NE1 1 
ATOM   209  C CE2 . TRP A 1 56  ? 182.40600 329.58400 16.23600  1.000 46.41157  ? 52  TRP F CE2 1 
ATOM   210  C CE3 . TRP A 1 56  ? 180.36200 328.34100 15.85200  1.000 46.63523  ? 52  TRP F CE3 1 
ATOM   211  C CZ2 . TRP A 1 56  ? 181.78900 330.79300 15.90000  1.000 43.86076  ? 52  TRP F CZ2 1 
ATOM   212  C CZ3 . TRP A 1 56  ? 179.74800 329.54600 15.52500  1.000 44.28330  ? 52  TRP F CZ3 1 
ATOM   213  C CH2 . TRP A 1 56  ? 180.46600 330.75400 15.55200  1.000 42.37042  ? 52  TRP F CH2 1 
ATOM   214  N N   . TYR A 1 57  ? 179.97900 323.72000 16.96600  1.000 54.08894  ? 53  TYR F N   1 
ATOM   215  C CA  . TYR A 1 57  ? 179.63100 322.35600 16.59700  1.000 54.02691  ? 53  TYR F CA  1 
ATOM   216  C C   . TYR A 1 57  ? 179.58800 322.33000 15.07300  1.000 51.38162  ? 53  TYR F C   1 
ATOM   217  O O   . TYR A 1 57  ? 178.76100 323.00700 14.46000  1.000 50.41042  ? 53  TYR F O   1 
ATOM   218  C CB  . TYR A 1 57  ? 178.30000 321.90000 17.19300  1.000 55.19961  ? 53  TYR F CB  1 
ATOM   219  C CG  . TYR A 1 57  ? 177.98300 320.50300 16.71200  1.000 60.11263  ? 53  TYR F CG  1 
ATOM   220  C CD1 . TYR A 1 57  ? 178.57200 319.40900 17.35500  1.000 60.91735  ? 53  TYR F CD1 1 
ATOM   221  C CD2 . TYR A 1 57  ? 177.15200 320.25600 15.62900  1.000 60.20420  ? 53  TYR F CD2 1 
ATOM   222  C CE1 . TYR A 1 57  ? 178.34000 318.10800 16.95000  1.000 62.87545  ? 53  TYR F CE1 1 
ATOM   223  C CE2 . TYR A 1 57  ? 176.90400 318.93900 15.21000  1.000 67.15290  ? 53  TYR F CE2 1 
ATOM   224  C CZ  . TYR A 1 57  ? 177.50800 317.87500 15.88400  1.000 68.06789  ? 53  TYR F CZ  1 
ATOM   225  O OH  . TYR A 1 57  ? 177.28900 316.57600 15.49600  1.000 70.82401  ? 53  TYR F OH  1 
ATOM   226  N N   . THR A 1 58  ? 180.52800 321.64100 14.44800  1.000 52.30553  ? 54  THR F N   1 
ATOM   227  C CA  . THR A 1 58  ? 180.52400 321.65000 12.99900  1.000 59.99526  ? 54  THR F CA  1 
ATOM   228  C C   . THR A 1 58  ? 179.69100 320.47400 12.50400  1.000 66.22048  ? 54  THR F C   1 
ATOM   229  O O   . THR A 1 58  ? 179.65700 319.40400 13.11600  1.000 69.02600  ? 54  THR F O   1 
ATOM   230  C CB  . THR A 1 58  ? 181.93700 321.50700 12.46700  1.000 56.75223  ? 54  THR F CB  1 
ATOM   231  O OG1 . THR A 1 58  ? 182.43900 320.24800 12.91900  1.000 64.88112  ? 54  THR F OG1 1 
ATOM   232  C CG2 . THR A 1 58  ? 182.81700 322.60200 13.03300  1.000 52.29905  ? 54  THR F CG2 1 
ATOM   233  N N   . SER A 1 59  ? 179.09100 320.64900 11.33800  1.000 69.58833  ? 55  SER F N   1 
ATOM   234  C CA  . SER A 1 59  ? 178.28000 319.59100 10.76600  1.000 67.45131  ? 55  SER F CA  1 
ATOM   235  C C   . SER A 1 59  ? 178.42000 319.66100 9.25500   1.000 69.00502  ? 55  SER F C   1 
ATOM   236  O O   . SER A 1 59  ? 178.55000 320.76000 8.70300   1.000 64.91136  ? 55  SER F O   1 
ATOM   237  C CB  . SER A 1 59  ? 176.82700 319.78600 11.21100  1.000 62.59402  ? 55  SER F CB  1 
ATOM   238  O OG  . SER A 1 59  ? 175.97800 318.76600 10.74500  1.000 73.93936  ? 55  SER F OG  1 
ATOM   239  N N   . VAL A 1 60  ? 178.48500 318.49300 8.59800   1.000 70.37858  ? 56  VAL F N   1 
ATOM   240  C CA  . VAL A 1 60  ? 178.66800 318.43600 7.14400   1.000 67.88849  ? 56  VAL F CA  1 
ATOM   241  C C   . VAL A 1 60  ? 177.31500 318.29100 6.43900   1.000 70.85140  ? 56  VAL F C   1 
ATOM   242  O O   . VAL A 1 60  ? 176.50700 317.42300 6.79100   1.000 70.21605  ? 56  VAL F O   1 
ATOM   243  C CB  . VAL A 1 60  ? 179.65500 317.33200 6.73500   1.000 66.80235  ? 56  VAL F CB  1 
ATOM   244  C CG1 . VAL A 1 60  ? 179.73500 317.25700 5.24600   1.000 70.06392  ? 56  VAL F CG1 1 
ATOM   245  C CG2 . VAL A 1 60  ? 181.02100 317.62700 7.29000   1.000 61.65798  ? 56  VAL F CG2 1 
ATOM   246  N N   . ILE A 1 61  ? 177.06400 319.14100 5.45100   1.000 69.01140  ? 57  ILE F N   1 
ATOM   247  C CA  . ILE A 1 61  ? 175.85400 319.09900 4.65100   1.000 66.89948  ? 57  ILE F CA  1 
ATOM   248  C C   . ILE A 1 61  ? 176.26400 318.73000 3.24100   1.000 72.17578  ? 57  ILE F C   1 
ATOM   249  O O   . ILE A 1 61  ? 177.15900 319.37300 2.66600   1.000 69.38262  ? 57  ILE F O   1 
ATOM   250  C CB  . ILE A 1 61  ? 175.08100 320.42500 4.64900   1.000 65.19835  ? 57  ILE F CB  1 
ATOM   251  C CG1 . ILE A 1 61  ? 174.93900 321.00000 6.05800   1.000 66.33690  ? 57  ILE F CG1 1 
ATOM   252  C CG2 . ILE A 1 61  ? 173.72000 320.25000 3.92200   1.000 65.83623  ? 57  ILE F CG2 1 
ATOM   253  C CD1 . ILE A 1 61  ? 174.13400 320.16700 6.98600   1.000 65.99651  ? 57  ILE F CD1 1 
ATOM   254  N N   . THR A 1 62  ? 175.75200 317.59500 2.76400   1.000 76.43530  ? 58  THR F N   1 
ATOM   255  C CA  . THR A 1 62  ? 176.04500 317.04000 1.45200   1.000 74.23781  ? 58  THR F CA  1 
ATOM   256  C C   . THR A 1 62  ? 174.82400 317.14900 0.54400   1.000 71.87680  ? 58  THR F C   1 
ATOM   257  O O   . THR A 1 62  ? 173.65300 317.11500 0.98000   1.000 70.41123  ? 58  THR F O   1 
ATOM   258  C CB  . THR A 1 62  ? 176.48000 315.58400 1.51900   1.000 73.19767  ? 58  THR F CB  1 
ATOM   259  O OG1 . THR A 1 62  ? 175.35100 314.77900 1.89500   1.000 79.28931  ? 58  THR F OG1 1 
ATOM   260  C CG2 . THR A 1 62  ? 177.62100 315.41500 2.51500   1.000 76.48998  ? 58  THR F CG2 1 
ATOM   261  N N   . ILE A 1 63  ? 175.14400 317.29400 -0.73300  1.000 70.21409  ? 59  ILE F N   1 
ATOM   262  C CA  . ILE A 1 63  ? 174.19700 317.28800 -1.83600  1.000 67.56012  ? 59  ILE F CA  1 
ATOM   263  C C   . ILE A 1 63  ? 174.70500 316.30600 -2.88400  1.000 66.81625  ? 59  ILE F C   1 
ATOM   264  O O   . ILE A 1 63  ? 175.83900 316.43600 -3.36600  1.000 62.31184  ? 59  ILE F O   1 
ATOM   265  C CB  . ILE A 1 63  ? 174.00200 318.68300 -2.44500  1.000 66.11728  ? 59  ILE F CB  1 
ATOM   266  C CG1 . ILE A 1 63  ? 173.26800 319.57200 -1.45400  1.000 63.82277  ? 59  ILE F CG1 1 
ATOM   267  C CG2 . ILE A 1 63  ? 173.18900 318.59900 -3.73400  1.000 63.86849  ? 59  ILE F CG2 1 
ATOM   268  C CD1 . ILE A 1 63  ? 172.97900 320.92600 -2.00100  1.000 62.23499  ? 59  ILE F CD1 1 
ATOM   269  N N   . GLU A 1 64  ? 173.92700 315.25600 -3.13400  1.000 74.54943  ? 60  GLU F N   1 
ATOM   270  C CA  . GLU A 1 64  ? 174.30400 314.22200 -4.09700  1.000 72.53851  ? 60  GLU F CA  1 
ATOM   271  C C   . GLU A 1 64  ? 174.17100 314.81000 -5.50300  1.000 68.37844  ? 60  GLU F C   1 
ATOM   272  O O   . GLU A 1 64  ? 173.07600 315.20000 -5.91400  1.000 65.98648  ? 60  GLU F O   1 
ATOM   273  C CB  . GLU A 1 64  ? 173.41000 312.99700 -3.92400  1.000 77.69587  ? 60  GLU F CB  1 
ATOM   274  C CG  . GLU A 1 64  ? 173.86500 312.02900 -2.85000  1.000 84.06716  ? 60  GLU F CG  1 
ATOM   275  C CD  . GLU A 1 64  ? 174.52200 310.78600 -3.43200  1.000 91.99817  ? 60  GLU F CD  1 
ATOM   276  O OE1 . GLU A 1 64  ? 175.75500 310.81200 -3.67900  1.000 90.87486  ? 60  GLU F OE1 1 
ATOM   277  O OE2 . GLU A 1 64  ? 173.78800 309.79300 -3.66000  1.000 91.54531  ? 60  GLU F OE2 1 
ATOM   278  N N   . LEU A 1 65  ? 175.28400 314.95800 -6.21900  1.000 68.57861  ? 61  LEU F N   1 
ATOM   279  C CA  . LEU A 1 65  ? 175.27100 315.56000 -7.54700  1.000 66.52890  ? 61  LEU F CA  1 
ATOM   280  C C   . LEU A 1 65  ? 175.40600 314.52200 -8.66700  1.000 75.71598  ? 61  LEU F C   1 
ATOM   281  O O   . LEU A 1 65  ? 175.83000 313.37600 -8.47200  1.000 74.62807  ? 61  LEU F O   1 
ATOM   282  C CB  . LEU A 1 65  ? 176.39600 316.59500 -7.65900  1.000 68.56019  ? 61  LEU F CB  1 
ATOM   283  C CG  . LEU A 1 65  ? 176.31000 317.85600 -6.79100  1.000 66.09778  ? 61  LEU F CG  1 
ATOM   284  C CD1 . LEU A 1 65  ? 177.45400 318.77500 -7.14400  1.000 62.39505  ? 61  LEU F CD1 1 
ATOM   285  C CD2 . LEU A 1 65  ? 174.97400 318.58200 -6.96800  1.000 57.15474  ? 61  LEU F CD2 1 
ATOM   286  N N   . SER A 1 66  ? 175.14000 314.99000 -9.88300  1.000 74.70427  ? 62  SER F N   1 
ATOM   287  C CA  . SER A 1 66  ? 175.18000 314.17300 -11.08800 1.000 76.15013  ? 62  SER F CA  1 
ATOM   288  C C   . SER A 1 66  ? 176.36500 314.60600 -11.93000 1.000 78.44289  ? 62  SER F C   1 
ATOM   289  O O   . SER A 1 66  ? 176.49600 315.78400 -12.28000 1.000 77.85790  ? 62  SER F O   1 
ATOM   290  C CB  . SER A 1 66  ? 173.88800 314.30000 -11.88200 1.000 78.56270  ? 62  SER F CB  1 
ATOM   291  O OG  . SER A 1 66  ? 173.94100 313.50900 -13.04200 1.000 81.95242  ? 62  SER F OG  1 
ATOM   292  N N   . ASN A 1 67  ? 177.26400 313.67900 -12.17700 1.000 85.33081  ? 63  ASN F N   1 
ATOM   293  C CA  . ASN A 1 67  ? 178.42400 313.99500 -12.98700 1.000 89.94480  ? 63  ASN F CA  1 
ATOM   294  C C   . ASN A 1 67  ? 178.05700 313.94400 -14.48300 1.000 94.57653  ? 63  ASN F C   1 
ATOM   295  O O   . ASN A 1 67  ? 178.83400 313.46900 -15.31600 1.000 92.59562  ? 63  ASN F O   1 
ATOM   296  C CB  . ASN A 1 67  ? 179.50700 312.98900 -12.60000 1.000 92.75434  ? 63  ASN F CB  1 
ATOM   297  C CG  . ASN A 1 67  ? 180.90800 313.48200 -12.88800 1.000 97.46323  ? 63  ASN F CG  1 
ATOM   298  O OD1 . ASN A 1 67  ? 181.46300 313.34200 -13.97500 1.000 100.31159 ? 63  ASN F OD1 1 
ATOM   299  N ND2 . ASN A 1 67  ? 181.53100 314.00500 -11.82200 1.000 94.12140  ? 63  ASN F ND2 1 
ATOM   300  N N   . ILE A 1 68  ? 176.86100 314.44300 -14.84400 1.000 96.40494  ? 64  ILE F N   1 
ATOM   301  C CA  . ILE A 1 68  ? 176.43400 314.41500 -16.24400 1.000 98.35189  ? 64  ILE F CA  1 
ATOM   302  C C   . ILE A 1 68  ? 177.42500 315.15500 -17.13200 1.000 101.80562 ? 64  ILE F C   1 
ATOM   303  O O   . ILE A 1 68  ? 178.10700 316.10100 -16.71700 1.000 102.50397 ? 64  ILE F O   1 
ATOM   304  C CB  . ILE A 1 68  ? 175.01900 314.98100 -16.48100 1.000 95.92138  ? 64  ILE F CB  1 
ATOM   305  C CG1 . ILE A 1 68  ? 174.88400 316.42500 -15.99600 1.000 91.21905  ? 64  ILE F CG1 1 
ATOM   306  C CG2 . ILE A 1 68  ? 173.95800 314.08300 -15.85700 1.000 93.20620  ? 64  ILE F CG2 1 
ATOM   307  C CD1 . ILE A 1 68  ? 174.91200 317.43900 -17.11800 1.000 95.09084  ? 64  ILE F CD1 1 
ATOM   308  N N   . LYS A 1 69  ? 177.46000 314.72700 -18.38400 1.000 107.37971 ? 65  LYS F N   1 
ATOM   309  C CA  . LYS A 1 69  ? 178.22000 315.28600 -19.48600 1.000 111.95108 ? 65  LYS F CA  1 
ATOM   310  C C   . LYS A 1 69  ? 177.20900 315.81000 -20.50100 1.000 114.17679 ? 65  LYS F C   1 
ATOM   311  O O   . LYS A 1 69  ? 176.01800 315.50200 -20.40100 1.000 114.09471 ? 65  LYS F O   1 
ATOM   312  C CB  . LYS A 1 69  ? 179.19200 314.18600 -19.98500 1.000 112.22730 ? 65  LYS F CB  1 
ATOM   313  C CG  . LYS A 1 69  ? 178.59100 312.93600 -20.65600 1.000 114.10247 ? 65  LYS F CG  1 
ATOM   314  C CD  . LYS A 1 69  ? 179.54700 312.38000 -21.72700 1.000 116.99321 ? 65  LYS F CD  1 
ATOM   315  C CE  . LYS A 1 69  ? 179.88000 313.28900 -22.91700 1.000 117.41935 ? 65  LYS F CE  1 
ATOM   316  N NZ  . LYS A 1 69  ? 178.77300 313.78500 -23.80600 1.000 117.27347 ? 65  LYS F NZ  1 
ATOM   317  N N   . GLU A 1 70  ? 177.63800 316.64300 -21.45200 1.000 115.28435 ? 66  GLU F N   1 
ATOM   318  C CA  . GLU A 1 70  ? 176.63400 317.23200 -22.33100 1.000 117.88026 ? 66  GLU F CA  1 
ATOM   319  C C   . GLU A 1 70  ? 175.98700 316.08900 -23.09200 1.000 120.65338 ? 66  GLU F C   1 
ATOM   320  O O   . GLU A 1 70  ? 176.67000 315.17500 -23.56700 1.000 120.64368 ? 66  GLU F O   1 
ATOM   321  C CB  . GLU A 1 70  ? 177.25000 318.21400 -23.33200 1.000 121.23042 ? 66  GLU F CB  1 
ATOM   322  C CG  . GLU A 1 70  ? 178.29600 317.56400 -24.23700 1.000 123.53487 ? 66  GLU F CG  1 
ATOM   323  C CD  . GLU A 1 70  ? 179.46000 318.46600 -24.58000 1.000 127.27630 ? 66  GLU F CD  1 
ATOM   324  O OE1 . GLU A 1 70  ? 179.43900 319.65200 -24.18500 1.000 130.97585 ? 66  GLU F OE1 1 
ATOM   325  O OE2 . GLU A 1 70  ? 180.41600 317.96500 -25.21700 1.000 126.17376 ? 66  GLU F OE2 1 
ATOM   326  N N   . ASN A 1 71  ? 174.66700 316.13200 -23.21600 1.000 120.05304 ? 67  ASN F N   1 
ATOM   327  C CA  . ASN A 1 71  ? 173.95100 315.09700 -23.95000 1.000 123.00922 ? 67  ASN F CA  1 
ATOM   328  C C   . ASN A 1 71  ? 173.02800 315.73700 -24.97900 1.000 124.61615 ? 67  ASN F C   1 
ATOM   329  O O   . ASN A 1 71  ? 171.80000 315.64800 -24.89700 1.000 124.15977 ? 67  ASN F O   1 
ATOM   330  C CB  . ASN A 1 71  ? 173.19600 314.18100 -22.99200 1.000 124.24797 ? 67  ASN F CB  1 
ATOM   331  C CG  . ASN A 1 71  ? 174.07300 313.05400 -22.46600 1.000 125.56209 ? 67  ASN F CG  1 
ATOM   332  O OD1 . ASN A 1 71  ? 174.85500 312.45700 -23.21200 1.000 127.01314 ? 67  ASN F OD1 1 
ATOM   333  N ND2 . ASN A 1 71  ? 173.96800 312.77700 -21.17100 1.000 125.99642 ? 67  ASN F ND2 1 
ATOM   334  N N   . LYS A 1 72  ? 173.64900 316.37800 -25.96000 1.000 126.14614 ? 68  LYS F N   1 
ATOM   335  C CA  . LYS A 1 72  ? 172.91600 317.03500 -27.02700 1.000 127.71038 ? 68  LYS F CA  1 
ATOM   336  C C   . LYS A 1 72  ? 172.37800 315.97000 -27.97400 1.000 127.69340 ? 68  LYS F C   1 
ATOM   337  O O   . LYS A 1 72  ? 173.13800 315.13100 -28.47100 1.000 126.48265 ? 68  LYS F O   1 
ATOM   338  C CB  . LYS A 1 72  ? 173.83200 317.99100 -27.79000 1.000 126.98651 ? 68  LYS F CB  1 
ATOM   339  C CG  . LYS A 1 72  ? 174.62900 318.95400 -26.91800 1.000 123.46804 ? 68  LYS F CG  1 
ATOM   340  C CD  . LYS A 1 72  ? 175.15600 320.12300 -27.74000 1.000 120.27747 ? 68  LYS F CD  1 
ATOM   341  C CE  . LYS A 1 72  ? 176.09000 321.00200 -26.91900 1.000 119.59282 ? 68  LYS F CE  1 
ATOM   342  N NZ  . LYS A 1 72  ? 176.66000 322.12200 -27.72000 1.000 109.79688 ? 68  LYS F NZ  1 
ATOM   343  N N   . CYS A 1 73  ? 171.07300 315.98300 -28.21400 1.000 128.52253 ? 69  CYS F N   1 
ATOM   344  C CA  . CYS A 1 73  ? 170.48800 315.07800 -29.19000 1.000 128.25061 ? 69  CYS F CA  1 
ATOM   345  C C   . CYS A 1 73  ? 169.56200 315.89300 -30.08100 1.000 126.70997 ? 69  CYS F C   1 
ATOM   346  O O   . CYS A 1 73  ? 169.29000 317.07000 -29.81400 1.000 122.41982 ? 69  CYS F O   1 
ATOM   347  C CB  . CYS A 1 73  ? 169.77100 313.88000 -28.51700 1.000 129.63398 ? 69  CYS F CB  1 
ATOM   348  S SG  . CYS A 1 73  ? 168.78100 314.14700 -26.97500 1.000 134.16303 ? 69  CYS F SG  1 
ATOM   349  N N   . ASN A 1 74  ? 169.10200 315.27500 -31.17200 1.000 128.97144 ? 70  ASN F N   1 
ATOM   350  C CA  . ASN A 1 74  ? 168.15400 315.96700 -32.03700 1.000 126.31101 ? 70  ASN F CA  1 
ATOM   351  C C   . ASN A 1 74  ? 166.94400 316.33300 -31.18300 1.000 124.49042 ? 70  ASN F C   1 
ATOM   352  O O   . ASN A 1 74  ? 166.10300 315.48800 -30.85000 1.000 122.93168 ? 70  ASN F O   1 
ATOM   353  C CB  . ASN A 1 74  ? 167.87100 315.10600 -33.27000 1.000 122.84818 ? 70  ASN F CB  1 
ATOM   354  C CG  . ASN A 1 74  ? 169.02200 315.17700 -34.27400 1.000 120.49327 ? 70  ASN F CG  1 
ATOM   355  O OD1 . ASN A 1 74  ? 169.89800 316.04000 -34.15600 1.000 121.08806 ? 70  ASN F OD1 1 
ATOM   356  N ND2 . ASN A 1 74  ? 169.06000 314.24100 -35.21700 1.000 114.82616 ? 70  ASN F ND2 1 
ATOM   357  N N   . GLY A 1 75  ? 166.84800 317.62600 -30.90300 1.000 120.52799 ? 71  GLY F N   1 
ATOM   358  C CA  . GLY A 1 75  ? 165.78000 318.16900 -30.07800 1.000 114.74371 ? 71  GLY F CA  1 
ATOM   359  C C   . GLY A 1 75  ? 165.13000 319.39600 -30.67500 1.000 113.26275 ? 71  GLY F C   1 
ATOM   360  O O   . GLY A 1 75  ? 165.80300 320.25600 -31.24200 1.000 111.14566 ? 71  GLY F O   1 
ATOM   361  N N   . THR A 1 76  ? 163.80400 319.45500 -30.56400 1.000 109.34996 ? 72  THR F N   1 
ATOM   362  C CA  . THR A 1 76  ? 163.00600 320.54500 -31.11700 1.000 104.19305 ? 72  THR F CA  1 
ATOM   363  C C   . THR A 1 76  ? 161.85500 320.91400 -30.18300 1.000 98.41836  ? 72  THR F C   1 
ATOM   364  O O   . THR A 1 76  ? 161.72500 322.08900 -29.83300 1.000 96.98616  ? 72  THR F O   1 
ATOM   365  C CB  . THR A 1 76  ? 162.49900 320.25200 -32.54000 1.000 106.51279 ? 72  THR F CB  1 
ATOM   366  O OG1 . THR A 1 76  ? 161.76500 319.02300 -32.58000 1.000 109.35681 ? 72  THR F OG1 1 
ATOM   367  C CG2 . THR A 1 76  ? 163.65800 320.22300 -33.54100 1.000 104.57113 ? 72  THR F CG2 1 
ATOM   368  N N   . ASP A 1 77  ? 161.00500 319.96600 -29.77600 1.000 100.42297 ? 73  ASP F N   1 
ATOM   369  C CA  . ASP A 1 77  ? 159.83900 320.34900 -28.97900 1.000 102.26937 ? 73  ASP F CA  1 
ATOM   370  C C   . ASP A 1 77  ? 160.23100 321.02100 -27.66600 1.000 100.71207 ? 73  ASP F C   1 
ATOM   371  O O   . ASP A 1 77  ? 161.28000 320.74700 -27.07300 1.000 99.40459  ? 73  ASP F O   1 
ATOM   372  C CB  . ASP A 1 77  ? 159.00800 319.12700 -28.60200 1.000 97.82946  ? 73  ASP F CB  1 
ATOM   373  C CG  . ASP A 1 77  ? 159.72000 318.25000 -27.58600 1.000 101.75362 ? 73  ASP F CG  1 
ATOM   374  O OD1 . ASP A 1 77  ? 160.96400 318.12700 -27.68300 1.000 106.06059 ? 73  ASP F OD1 1 
ATOM   375  O OD2 . ASP A 1 77  ? 159.04800 317.73800 -26.65700 1.000 101.13357 ? 73  ASP F OD2 1 
ATOM   376  N N   . ALA A 1 78  ? 159.35600 321.93100 -27.22700 1.000 98.23680  ? 74  ALA F N   1 
ATOM   377  C CA  . ALA A 1 78  ? 159.71100 322.87000 -26.17000 1.000 95.21384  ? 74  ALA F CA  1 
ATOM   378  C C   . ALA A 1 78  ? 160.06100 322.18500 -24.85500 1.000 92.14037  ? 74  ALA F C   1 
ATOM   379  O O   . ALA A 1 78  ? 160.82300 322.74300 -24.06200 1.000 91.56426  ? 74  ALA F O   1 
ATOM   380  C CB  . ALA A 1 78  ? 158.56700 323.85700 -25.95500 1.000 94.71080  ? 74  ALA F CB  1 
ATOM   381  N N   . LYS A 1 79  ? 159.52500 320.98700 -24.59600 1.000 89.90297  ? 75  LYS F N   1 
ATOM   382  C CA  . LYS A 1 79  ? 159.79900 320.33800 -23.31100 1.000 86.08149  ? 75  LYS F CA  1 
ATOM   383  C C   . LYS A 1 79  ? 161.25900 319.89600 -23.20100 1.000 88.33870  ? 75  LYS F C   1 
ATOM   384  O O   . LYS A 1 79  ? 161.89000 320.03500 -22.14500 1.000 87.37343  ? 75  LYS F O   1 
ATOM   385  C CB  . LYS A 1 79  ? 158.85200 319.17300 -23.13100 1.000 86.54771  ? 75  LYS F CB  1 
ATOM   386  C CG  . LYS A 1 79  ? 157.45700 319.61000 -22.71800 1.000 86.74170  ? 75  LYS F CG  1 
ATOM   387  C CD  . LYS A 1 79  ? 156.62800 318.37500 -22.39000 1.000 91.54072  ? 75  LYS F CD  1 
ATOM   388  C CE  . LYS A 1 79  ? 155.42500 318.24900 -23.32700 1.000 86.87275  ? 75  LYS F CE  1 
ATOM   389  N NZ  . LYS A 1 79  ? 154.54600 317.14100 -22.83700 1.000 85.53032  ? 75  LYS F NZ  1 
ATOM   390  N N   . VAL A 1 80  ? 161.84200 319.43900 -24.30100 1.000 89.23693  ? 76  VAL F N   1 
ATOM   391  C CA  . VAL A 1 80  ? 163.25400 319.09100 -24.28000 1.000 88.34152  ? 76  VAL F CA  1 
ATOM   392  C C   . VAL A 1 80  ? 164.09200 320.34800 -24.10500 1.000 83.53859  ? 76  VAL F C   1 
ATOM   393  O O   . VAL A 1 80  ? 165.10400 320.33300 -23.40200 1.000 82.65858  ? 76  VAL F O   1 
ATOM   394  C CB  . VAL A 1 80  ? 163.63400 318.28900 -25.55100 1.000 88.86235  ? 76  VAL F CB  1 
ATOM   395  C CG1 . VAL A 1 80  ? 165.15500 318.14500 -25.65900 1.000 91.16341  ? 76  VAL F CG1 1 
ATOM   396  C CG2 . VAL A 1 80  ? 162.94200 316.92500 -25.53300 1.000 90.91853  ? 76  VAL F CG2 1 
ATOM   397  N N   . LYS A 1 81  ? 163.71300 321.44000 -24.77300 1.000 82.91263  ? 77  LYS F N   1 
ATOM   398  C CA  . LYS A 1 81  ? 164.46000 322.67800 -24.61200 1.000 83.51284  ? 77  LYS F CA  1 
ATOM   399  C C   . LYS A 1 81  ? 164.39500 323.16000 -23.15900 1.000 80.16491  ? 77  LYS F C   1 
ATOM   400  O O   . LYS A 1 81  ? 165.40400 323.60600 -22.61000 1.000 80.91756  ? 77  LYS F O   1 
ATOM   401  C CB  . LYS A 1 81  ? 163.95300 323.71400 -25.61700 1.000 86.31652  ? 77  LYS F CB  1 
ATOM   402  C CG  . LYS A 1 81  ? 164.90800 324.89200 -25.84100 1.000 88.61461  ? 77  LYS F CG  1 
ATOM   403  C CD  . LYS A 1 81  ? 164.35500 325.94800 -26.80800 1.000 90.39030  ? 77  LYS F CD  1 
ATOM   404  C CE  . LYS A 1 81  ? 162.83000 325.83400 -26.95700 1.000 93.49219  ? 77  LYS F CE  1 
ATOM   405  N NZ  . LYS A 1 81  ? 162.28200 326.97200 -27.76500 1.000 93.93075  ? 77  LYS F NZ  1 
ATOM   406  N N   . LEU A 1 82  ? 163.22300 323.09300 -22.51800 1.000 76.47327  ? 78  LEU F N   1 
ATOM   407  C CA  . LEU A 1 82  ? 163.14000 323.55600 -21.14000 1.000 74.25697  ? 78  LEU F CA  1 
ATOM   408  C C   . LEU A 1 82  ? 164.01300 322.68400 -20.24400 1.000 76.84199  ? 78  LEU F C   1 
ATOM   409  O O   . LEU A 1 82  ? 164.72100 323.18300 -19.35900 1.000 74.88338  ? 78  LEU F O   1 
ATOM   410  C CB  . LEU A 1 82  ? 161.68800 323.56100 -20.67000 1.000 75.80290  ? 78  LEU F CB  1 
ATOM   411  C CG  . LEU A 1 82  ? 160.82400 324.66400 -21.28900 1.000 76.50395  ? 78  LEU F CG  1 
ATOM   412  C CD1 . LEU A 1 82  ? 159.37800 324.43800 -20.91700 1.000 73.39738  ? 78  LEU F CD1 1 
ATOM   413  C CD2 . LEU A 1 82  ? 161.28700 326.06300 -20.87100 1.000 76.34779  ? 78  LEU F CD2 1 
ATOM   414  N N   . ILE A 1 83  ? 164.00600 321.37700 -20.48300 1.000 74.65205  ? 79  ILE F N   1 
ATOM   415  C CA  . ILE A 1 83  ? 164.84300 320.49700 -19.68500 1.000 67.56383  ? 79  ILE F CA  1 
ATOM   416  C C   . ILE A 1 83  ? 166.31200 320.82500 -19.90400 1.000 74.79648  ? 79  ILE F C   1 
ATOM   417  O O   . ILE A 1 83  ? 167.10300 320.85800 -18.95900 1.000 75.28057  ? 79  ILE F O   1 
ATOM   418  C CB  . ILE A 1 83  ? 164.55600 319.02500 -20.00300 1.000 70.86451  ? 79  ILE F CB  1 
ATOM   419  C CG1 . ILE A 1 83  ? 163.31800 318.59100 -19.23600 1.000 74.08719  ? 79  ILE F CG1 1 
ATOM   420  C CG2 . ILE A 1 83  ? 165.77400 318.18800 -19.62900 1.000 70.22790  ? 79  ILE F CG2 1 
ATOM   421  C CD1 . ILE A 1 83  ? 163.49400 318.64600 -17.73900 1.000 73.61188  ? 79  ILE F CD1 1 
ATOM   422  N N   . LYS A 1 84  ? 166.71500 320.99700 -21.16200 1.000 76.09632  ? 80  LYS F N   1 
ATOM   423  C CA  . LYS A 1 84  ? 168.10800 321.29900 -21.46400 1.000 72.92189  ? 80  LYS F CA  1 
ATOM   424  C C   . LYS A 1 84  ? 168.52400 322.65100 -20.89600 1.000 71.49536  ? 80  LYS F C   1 
ATOM   425  O O   . LYS A 1 84  ? 169.65900 322.80900 -20.44000 1.000 72.37990  ? 80  LYS F O   1 
ATOM   426  C CB  . LYS A 1 84  ? 168.31700 321.26100 -22.98200 1.000 80.85729  ? 80  LYS F CB  1 
ATOM   427  C CG  . LYS A 1 84  ? 168.03900 319.89000 -23.62500 1.000 86.62905  ? 80  LYS F CG  1 
ATOM   428  C CD  . LYS A 1 84  ? 169.24200 319.34600 -24.38700 1.000 96.46496  ? 80  LYS F CD  1 
ATOM   429  C CE  . LYS A 1 84  ? 168.81500 318.43800 -25.53700 1.000 105.45995 ? 80  LYS F CE  1 
ATOM   430  N NZ  . LYS A 1 84  ? 169.90500 318.24500 -26.54300 1.000 111.44728 ? 80  LYS F NZ  1 
ATOM   431  N N   . GLN A 1 85  ? 167.60500 323.61200 -20.85200 1.000 72.48040  ? 81  GLN F N   1 
ATOM   432  C CA  . GLN A 1 85  ? 167.88200 324.90800 -20.23600 1.000 73.89922  ? 81  GLN F CA  1 
ATOM   433  C C   . GLN A 1 85  ? 168.12500 324.76400 -18.73600 1.000 75.67554  ? 81  GLN F C   1 
ATOM   434  O O   . GLN A 1 85  ? 169.11300 325.29300 -18.19200 1.000 74.76398  ? 81  GLN F O   1 
ATOM   435  C CB  . GLN A 1 85  ? 166.72500 325.87400 -20.51100 1.000 76.02036  ? 81  GLN F CB  1 
ATOM   436  C CG  . GLN A 1 85  ? 166.70900 326.46000 -21.91900 1.000 81.31404  ? 81  GLN F CG  1 
ATOM   437  C CD  . GLN A 1 85  ? 165.66000 327.54800 -22.09400 1.000 88.44230  ? 81  GLN F CD  1 
ATOM   438  O OE1 . GLN A 1 85  ? 165.07000 328.02100 -21.11800 1.000 93.06318  ? 81  GLN F OE1 1 
ATOM   439  N NE2 . GLN A 1 85  ? 165.42200 327.95000 -23.34000 1.000 88.22944  ? 81  GLN F NE2 1 
ATOM   440  N N   . GLU A 1 86  ? 167.22600 324.05600 -18.04300 1.000 72.97308  ? 82  GLU F N   1 
ATOM   441  C CA  . GLU A 1 86  ? 167.43600 323.84000 -16.61900 1.000 68.84366  ? 82  GLU F CA  1 
ATOM   442  C C   . GLU A 1 86  ? 168.68700 322.99100 -16.37300 1.000 68.72784  ? 82  GLU F C   1 
ATOM   443  O O   . GLU A 1 86  ? 169.38500 323.17600 -15.36600 1.000 69.41381  ? 82  GLU F O   1 
ATOM   444  C CB  . GLU A 1 86  ? 166.19300 323.18400 -16.01400 1.000 65.82742  ? 82  GLU F CB  1 
ATOM   445  C CG  . GLU A 1 86  ? 166.20800 323.08800 -14.49600 1.000 69.54464  ? 82  GLU F CG  1 
ATOM   446  C CD  . GLU A 1 86  ? 166.10700 324.48500 -13.81400 1.000 71.15474  ? 82  GLU F CD  1 
ATOM   447  O OE1 . GLU A 1 86  ? 165.61400 325.44800 -14.45500 1.000 71.77447  ? 82  GLU F OE1 1 
ATOM   448  O OE2 . GLU A 1 86  ? 166.52500 324.62400 -12.63900 1.000 72.10174  ? 82  GLU F OE2 1 
ATOM   449  N N   . LEU A 1 87  ? 169.02600 322.09800 -17.30500 1.000 64.23932  ? 83  LEU F N   1 
ATOM   450  C CA  . LEU A 1 87  ? 170.23200 321.29800 -17.14700 1.000 63.90644  ? 83  LEU F CA  1 
ATOM   451  C C   . LEU A 1 87  ? 171.48000 322.14600 -17.30300 1.000 71.07737  ? 83  LEU F C   1 
ATOM   452  O O   . LEU A 1 87  ? 172.49400 321.88700 -16.64500 1.000 70.52482  ? 83  LEU F O   1 
ATOM   453  C CB  . LEU A 1 87  ? 170.23200 320.15800 -18.15300 1.000 67.55528  ? 83  LEU F CB  1 
ATOM   454  C CG  . LEU A 1 87  ? 169.65300 318.88400 -17.55000 1.000 70.58787  ? 83  LEU F CG  1 
ATOM   455  C CD1 . LEU A 1 87  ? 169.43300 317.87100 -18.64500 1.000 70.57457  ? 83  LEU F CD1 1 
ATOM   456  C CD2 . LEU A 1 87  ? 170.56800 318.32700 -16.45600 1.000 70.39429  ? 83  LEU F CD2 1 
ATOM   457  N N   . ASP A 1 88  ? 171.43100 323.16200 -18.16400 1.000 69.22239  ? 84  ASP F N   1 
ATOM   458  C CA  . ASP A 1 88  ? 172.57200 324.05900 -18.27000 1.000 67.93756  ? 84  ASP F CA  1 
ATOM   459  C C   . ASP A 1 88  ? 172.69100 324.93100 -17.02500 1.000 70.86458  ? 84  ASP F C   1 
ATOM   460  O O   . ASP A 1 88  ? 173.80600 325.28600 -16.62400 1.000 69.92465  ? 84  ASP F O   1 
ATOM   461  C CB  . ASP A 1 88  ? 172.49600 324.90800 -19.54000 1.000 71.97468  ? 84  ASP F CB  1 
ATOM   462  C CG  . ASP A 1 88  ? 172.74500 324.09600 -20.80300 1.000 79.56890  ? 84  ASP F CG  1 
ATOM   463  O OD1 . ASP A 1 88  ? 173.34400 322.99600 -20.71300 1.000 82.20803  ? 84  ASP F OD1 1 
ATOM   464  O OD2 . ASP A 1 88  ? 172.33800 324.55700 -21.88700 1.000 85.25447  ? 84  ASP F OD2 1 
ATOM   465  N N   . LYS A 1 89  ? 171.56100 325.31900 -16.42200 1.000 67.57107  ? 85  LYS F N   1 
ATOM   466  C CA  . LYS A 1 89  ? 171.66100 326.05000 -15.15900 1.000 65.98397  ? 85  LYS F CA  1 
ATOM   467  C C   . LYS A 1 89  ? 172.26200 325.18700 -14.04100 1.000 65.92607  ? 85  LYS F C   1 
ATOM   468  O O   . LYS A 1 89  ? 173.11300 325.67100 -13.27300 1.000 66.75435  ? 85  LYS F O   1 
ATOM   469  C CB  . LYS A 1 89  ? 170.26000 326.51400 -14.73900 1.000 67.69676  ? 85  LYS F CB  1 
ATOM   470  C CG  . LYS A 1 89  ? 169.69000 327.69800 -15.50700 1.000 70.00680  ? 85  LYS F CG  1 
ATOM   471  C CD  . LYS A 1 89  ? 168.59700 328.41600 -14.73200 1.000 68.95697  ? 85  LYS F CD  1 
ATOM   472  C CE  . LYS A 1 89  ? 167.21600 328.16100 -15.30900 1.000 75.81036  ? 85  LYS F CE  1 
ATOM   473  N NZ  . LYS A 1 89  ? 166.13700 328.22200 -14.25800 1.000 78.94374  ? 85  LYS F NZ  1 
ATOM   474  N N   . TYR A 1 90  ? 172.00100 323.87100 -14.07300 1.000 65.03910  ? 86  TYR F N   1 
ATOM   475  C CA  . TYR A 1 90  ? 172.66200 322.92500 -13.16500 1.000 59.28606  ? 86  TYR F CA  1 
ATOM   476  C C   . TYR A 1 90  ? 174.15000 322.78600 -13.45700 1.000 63.74749  ? 86  TYR F C   1 
ATOM   477  O O   . TYR A 1 90  ? 174.99200 322.75500 -12.54000 1.000 66.68902  ? 86  TYR F O   1 
ATOM   478  C CB  . TYR A 1 90  ? 171.95600 321.56900 -13.28600 1.000 59.80074  ? 86  TYR F CB  1 
ATOM   479  C CG  . TYR A 1 90  ? 172.68100 320.42900 -12.63700 1.000 55.97297  ? 86  TYR F CG  1 
ATOM   480  C CD1 . TYR A 1 90  ? 173.63600 319.71600 -13.35000 1.000 54.75400  ? 86  TYR F CD1 1 
ATOM   481  C CD2 . TYR A 1 90  ? 172.42600 320.06100 -11.32500 1.000 53.42557  ? 86  TYR F CD2 1 
ATOM   482  C CE1 . TYR A 1 90  ? 174.32400 318.68400 -12.78000 1.000 55.88920  ? 86  TYR F CE1 1 
ATOM   483  C CE2 . TYR A 1 90  ? 173.12100 319.02200 -10.73500 1.000 54.76594  ? 86  TYR F CE2 1 
ATOM   484  C CZ  . TYR A 1 90  ? 174.07300 318.33500 -11.48100 1.000 58.58006  ? 86  TYR F CZ  1 
ATOM   485  O OH  . TYR A 1 90  ? 174.78900 317.29000 -10.95000 1.000 59.25766  ? 86  TYR F OH  1 
ATOM   486  N N   . LYS A 1 91  ? 174.49100 322.81100 -14.73400 1.000 66.64422  ? 87  LYS F N   1 
ATOM   487  C CA  . LYS A 1 91  ? 175.86600 322.62100 -15.17400 1.000 66.52733  ? 87  LYS F CA  1 
ATOM   488  C C   . LYS A 1 91  ? 176.71500 323.83700 -14.79700 1.000 66.53938  ? 87  LYS F C   1 
ATOM   489  O O   . LYS A 1 91  ? 177.83200 323.69700 -14.27200 1.000 65.65976  ? 87  LYS F O   1 
ATOM   490  C CB  . LYS A 1 91  ? 175.78700 322.40100 -16.68600 1.000 72.89019  ? 87  LYS F CB  1 
ATOM   491  C CG  . LYS A 1 91  ? 175.05200 321.07000 -17.06600 1.000 77.66176  ? 87  LYS F CG  1 
ATOM   492  C CD  . LYS A 1 91  ? 174.57100 321.02200 -18.54700 1.000 82.32653  ? 87  LYS F CD  1 
ATOM   493  C CE  . LYS A 1 91  ? 174.98700 319.81000 -19.36300 1.000 90.70011  ? 87  LYS F CE  1 
ATOM   494  N NZ  . LYS A 1 91  ? 176.45500 319.61600 -19.45000 1.000 96.20154  ? 87  LYS F NZ  1 
ATOM   495  N N   . ASN A 1 92  ? 176.16600 325.04200 -15.00300 1.000 69.49529  ? 88  ASN F N   1 
ATOM   496  C CA  A ASN A 1 92  ? 176.87500 326.25400 -14.61500 0.720 68.10886  ? 88  ASN F CA  1 
ATOM   497  C CA  B ASN A 1 92  ? 176.87500 326.25600 -14.61600 0.280 68.02359  ? 88  ASN F CA  1 
ATOM   498  C C   . ASN A 1 92  ? 177.00900 326.35000 -13.10300 1.000 67.99939  ? 88  ASN F C   1 
ATOM   499  O O   . ASN A 1 92  ? 178.02700 326.82700 -12.60100 1.000 68.30415  ? 88  ASN F O   1 
ATOM   500  C CB  A ASN A 1 92  ? 176.16500 327.48400 -15.17500 0.720 67.12989  ? 88  ASN F CB  1 
ATOM   501  C CB  B ASN A 1 92  ? 176.18600 327.50200 -15.19800 0.280 66.86760  ? 88  ASN F CB  1 
ATOM   502  C CG  A ASN A 1 92  ? 176.30000 327.59000 -16.67200 0.720 67.77511  ? 88  ASN F CG  1 
ATOM   503  C CG  B ASN A 1 92  ? 174.92400 327.92700 -14.43200 0.280 68.24571  ? 88  ASN F CG  1 
ATOM   504  O OD1 A ASN A 1 92  ? 177.29900 327.16700 -17.24400 0.720 68.00511  ? 88  ASN F OD1 1 
ATOM   505  O OD1 B ASN A 1 92  ? 174.87900 327.91800 -13.20200 0.280 67.51583  ? 88  ASN F OD1 1 
ATOM   506  N ND2 A ASN A 1 92  ? 175.29000 328.15300 -17.31900 0.720 68.94394  ? 88  ASN F ND2 1 
ATOM   507  N ND2 B ASN A 1 92  ? 173.90300 328.34200 -15.17700 0.280 68.54129  ? 88  ASN F ND2 1 
ATOM   508  N N   . ALA A 1 93  ? 175.99800 325.89600 -12.35600 1.000 66.10782  ? 89  ALA F N   1 
ATOM   509  C CA  . ALA A 1 93  ? 176.15000 325.91600 -10.90300 1.000 67.84102  ? 89  ALA F CA  1 
ATOM   510  C C   . ALA A 1 93  ? 177.29100 325.01200 -10.45400 1.000 68.83852  ? 89  ALA F C   1 
ATOM   511  O O   . ALA A 1 93  ? 178.08500 325.38700 -9.57500  1.000 70.60177  ? 89  ALA F O   1 
ATOM   512  C CB  . ALA A 1 93  ? 174.84800 325.50600 -10.21700 1.000 61.44863  ? 89  ALA F CB  1 
ATOM   513  N N   . VAL A 1 94  ? 177.46300 323.86700 -11.11700 1.000 67.15617  ? 90  VAL F N   1 
ATOM   514  C CA  . VAL A 1 94  ? 178.56600 322.98300 -10.73000 1.000 65.90249  ? 90  VAL F CA  1 
ATOM   515  C C   . VAL A 1 94  ? 179.91900 323.57500 -11.10100 1.000 66.86116  ? 90  VAL F C   1 
ATOM   516  O O   . VAL A 1 94  ? 180.86900 323.52500 -10.30500 1.000 69.28227  ? 90  VAL F O   1 
ATOM   517  C CB  . VAL A 1 94  ? 178.37900 321.59100 -11.35900 1.000 65.89962  ? 90  VAL F CB  1 
ATOM   518  C CG1 . VAL A 1 94  ? 179.58700 320.71300 -11.07700 1.000 60.74370  ? 90  VAL F CG1 1 
ATOM   519  C CG2 . VAL A 1 94  ? 177.11600 320.94100 -10.80800 1.000 67.93765  ? 90  VAL F CG2 1 
ATOM   520  N N   . THR A 1 95  ? 180.03800 324.16800 -12.28800 1.000 67.22792  ? 91  THR F N   1 
ATOM   521  C CA  . THR A 1 95  ? 181.33800 324.74500 -12.63000 1.000 68.12340  ? 91  THR F CA  1 
ATOM   522  C C   . THR A 1 95  ? 181.63700 325.98200 -11.77900 1.000 72.77380  ? 91  THR F C   1 
ATOM   523  O O   . THR A 1 95  ? 182.80100 326.22300 -11.41600 1.000 74.44273  ? 91  THR F O   1 
ATOM   524  C CB  . THR A 1 95  ? 181.40300 325.07700 -14.11100 1.000 65.74688  ? 91  THR F CB  1 
ATOM   525  O OG1 . THR A 1 95  ? 180.39000 326.04300 -14.41200 1.000 74.65538  ? 91  THR F OG1 1 
ATOM   526  C CG2 . THR A 1 95  ? 181.20900 323.82900 -14.94900 1.000 67.76990  ? 91  THR F CG2 1 
ATOM   527  N N   . ASP A 1 96  ? 180.59800 326.73000 -11.38200 1.000 70.92150  ? 92  ASP F N   1 
ATOM   528  C CA  . ASP A 1 96  ? 180.80600 327.87700 -10.50600 1.000 68.47629  ? 92  ASP F CA  1 
ATOM   529  C C   . ASP A 1 96  ? 181.31300 327.42200 -9.14900  1.000 72.97095  ? 92  ASP F C   1 
ATOM   530  O O   . ASP A 1 96  ? 182.23600 328.02900 -8.59900  1.000 75.33100  ? 92  ASP F O   1 
ATOM   531  C CB  . ASP A 1 96  ? 179.49800 328.65800 -10.33600 1.000 70.91878  ? 92  ASP F CB  1 
ATOM   532  C CG  . ASP A 1 96  ? 179.14000 329.51100 -11.55400 1.000 75.47310  ? 92  ASP F CG  1 
ATOM   533  O OD1 . ASP A 1 96  ? 180.06100 329.89300 -12.30500 1.000 80.67279  ? 92  ASP F OD1 1 
ATOM   534  O OD2 . ASP A 1 96  ? 177.92000 329.66700 -11.83100 1.000 76.82367  ? 92  ASP F OD2 1 
ATOM   535  N N   . LEU A 1 97  ? 180.76900 326.31900 -8.61400  1.000 67.23112  ? 93  LEU F N   1 
ATOM   536  C CA  . LEU A 1 97  ? 181.30500 325.79900 -7.35800  1.000 63.61499  ? 93  LEU F CA  1 
ATOM   537  C C   . LEU A 1 97  ? 182.69700 325.22000 -7.52500  1.000 71.72158  ? 93  LEU F C   1 
ATOM   538  O O   . LEU A 1 97  ? 183.48300 325.22000 -6.56500  1.000 75.52822  ? 93  LEU F O   1 
ATOM   539  C CB  . LEU A 1 97  ? 180.40700 324.73400 -6.73700  1.000 63.51090  ? 93  LEU F CB  1 
ATOM   540  C CG  . LEU A 1 97  ? 179.08200 325.11300 -6.08600  1.000 68.13890  ? 93  LEU F CG  1 
ATOM   541  C CD1 . LEU A 1 97  ? 178.32800 326.13400 -6.88000  1.000 68.35039  ? 93  LEU F CD1 1 
ATOM   542  C CD2 . LEU A 1 97  ? 178.24200 323.85400 -5.91000  1.000 67.25752  ? 93  LEU F CD2 1 
ATOM   543  N N   . GLN A 1 98  ? 183.05600 324.79900 -8.73400  1.000 73.41961  ? 94  GLN F N   1 
ATOM   544  C CA  . GLN A 1 98  ? 184.39100 324.23900 -8.86700  1.000 76.20562  ? 94  GLN F CA  1 
ATOM   545  C C   . GLN A 1 98  ? 185.41800 325.36400 -8.84200  1.000 75.01139  ? 94  GLN F C   1 
ATOM   546  O O   . GLN A 1 98  ? 186.43600 325.27200 -8.13400  1.000 79.45915  ? 94  GLN F O   1 
ATOM   547  C CB  . GLN A 1 98  ? 184.48700 323.42300 -10.16900 1.000 77.50312  ? 94  GLN F CB  1 
ATOM   548  C CG  . GLN A 1 98  ? 183.76600 322.05700 -10.16100 1.000 75.19053  ? 94  GLN F CG  1 
ATOM   549  C CD  . GLN A 1 98  ? 183.85400 321.34300 -11.51400 1.000 74.75018  ? 94  GLN F CD  1 
ATOM   550  O OE1 . GLN A 1 98  ? 183.16500 321.71900 -12.46700 1.000 75.66740  ? 94  GLN F OE1 1 
ATOM   551  N NE2 . GLN A 1 98  ? 184.70200 320.32100 -11.60300 1.000 70.93172  ? 94  GLN F NE2 1 
ATOM   552  N N   . LEU A 1 99  ? 185.14600 326.45400 -9.55700  1.000 77.26002  ? 95  LEU F N   1 
ATOM   553  C CA  . LEU A 1 99  ? 186.07500 327.61100 -9.50400  1.000 77.57034  ? 95  LEU F CA  1 
ATOM   554  C C   . LEU A 1 99  ? 186.01600 328.25600 -8.11700  1.000 79.22769  ? 95  LEU F C   1 
ATOM   555  O O   . LEU A 1 99  ? 187.01900 328.85100 -7.71200  1.000 86.04611  ? 95  LEU F O   1 
ATOM   556  C CB  . LEU A 1 99  ? 185.80300 328.60800 -10.63700 1.000 78.20493  ? 95  LEU F CB  1 
ATOM   557  C CG  . LEU A 1 99  ? 184.40900 329.22300 -10.73900 1.000 82.40706  ? 95  LEU F CG  1 
ATOM   558  C CD1 . LEU A 1 99  ? 184.35600 330.59000 -10.07200 1.000 83.31758  ? 95  LEU F CD1 1 
ATOM   559  C CD2 . LEU A 1 99  ? 183.99400 329.34600 -12.19500 1.000 83.44499  ? 95  LEU F CD2 1 
ATOM   560  N N   . LEU A 1 100 ? 184.90000 328.09800 -7.40700  1.000 79.14049  ? 96  LEU F N   1 
ATOM   561  C CA  . LEU A 1 100 ? 184.82800 328.65900 -6.06200  1.000 78.27006  ? 96  LEU F CA  1 
ATOM   562  C C   . LEU A 1 100 ? 185.66900 327.86600 -5.08300  1.000 81.53730  ? 96  LEU F C   1 
ATOM   563  O O   . LEU A 1 100 ? 186.25600 328.45100 -4.17000  1.000 89.73897  ? 96  LEU F O   1 
ATOM   564  C CB  . LEU A 1 100 ? 183.38600 328.73600 -5.55700  1.000 78.13138  ? 96  LEU F CB  1 
ATOM   565  C CG  . LEU A 1 100 ? 183.22200 329.28500 -4.13300  1.000 70.79166  ? 96  LEU F CG  1 
ATOM   566  C CD1 . LEU A 1 100 ? 184.24500 330.37100 -3.83900  1.000 79.55894  ? 96  LEU F CD1 1 
ATOM   567  C CD2 . LEU A 1 100 ? 181.83400 329.85000 -3.94800  1.000 70.48298  ? 96  LEU F CD2 1 
ATOM   568  N N   . MET A 1 101 ? 185.82200 326.56000 -5.30300  1.000 81.77294  ? 97  MET F N   1 
ATOM   569  C CA  . MET A 1 101 ? 186.60600 325.77900 -4.35400  1.000 83.52234  ? 97  MET F CA  1 
ATOM   570  C C   . MET A 1 101 ? 188.08300 325.77500 -4.69400  1.000 87.93594  ? 97  MET F C   1 
ATOM   571  O O   . MET A 1 101 ? 188.90900 325.49900 -3.81400  1.000 89.42632  ? 97  MET F O   1 
ATOM   572  C CB  . MET A 1 101 ? 186.09600 324.32700 -4.31200  1.000 79.67599  ? 97  MET F CB  1 
ATOM   573  C CG  . MET A 1 101 ? 186.77600 323.38200 -5.33700  1.000 87.30419  ? 97  MET F CG  1 
ATOM   574  S SD  . MET A 1 101 ? 187.00200 321.64500 -4.81700  1.000 92.88595  ? 97  MET F SD  1 
ATOM   575  C CE  . MET A 1 101 ? 187.57000 320.86000 -6.32400  1.000 76.67854  ? 97  MET F CE  1 
ATOM   576  N N   . GLN A 1 102 ? 188.44400 326.08400 -5.93900  1.000 89.38287  ? 98  GLN F N   1 
ATOM   577  C CA  . GLN A 1 102 ? 189.86000 326.29300 -6.21400  1.000 89.89396  ? 98  GLN F CA  1 
ATOM   578  C C   . GLN A 1 102 ? 190.41000 327.49400 -5.45200  1.000 91.21497  ? 98  GLN F C   1 
ATOM   579  O O   . GLN A 1 102 ? 191.48200 327.41400 -4.84100  1.000 92.54334  ? 98  GLN F O   1 
ATOM   580  C CB  . GLN A 1 102 ? 190.09400 326.47000 -7.71300  1.000 88.14609  ? 98  GLN F CB  1 
ATOM   581  C CG  . GLN A 1 102 ? 190.19800 325.15800 -8.46800  1.000 92.03210  ? 98  GLN F CG  1 
ATOM   582  C CD  . GLN A 1 102 ? 190.76300 325.34200 -9.86000  1.000 98.23277  ? 98  GLN F CD  1 
ATOM   583  O OE1 . GLN A 1 102 ? 190.29900 326.19300 -10.62200 1.000 102.01495 ? 98  GLN F OE1 1 
ATOM   584  N NE2 . GLN A 1 102 ? 191.77300 324.54400 -10.20200 1.000 95.48917  ? 98  GLN F NE2 1 
ATOM   585  N N   . SER A 1 103 ? 189.65800 328.59400 -5.42200  1.000 90.37503  ? 99  SER F N   1 
ATOM   586  C CA  . SER A 1 103 ? 190.05700 329.80600 -4.71400  1.000 89.39983  ? 99  SER F CA  1 
ATOM   587  C C   . SER A 1 103 ? 189.39000 329.95300 -3.35400  1.000 96.15284  ? 99  SER F C   1 
ATOM   588  O O   . SER A 1 103 ? 188.20000 330.28300 -3.28200  1.000 98.07100  ? 99  SER F O   1 
ATOM   589  C CB  . SER A 1 103 ? 189.70400 331.03900 -5.55500  1.000 86.86517  ? 99  SER F CB  1 
ATOM   590  O OG  . SER A 1 103 ? 190.15600 330.96500 -6.89900  1.000 85.85951  ? 99  SER F OG  1 
ATOM   591  N N   . THR A 1 104 ? 190.14300 329.75800 -2.26800  1.000 100.00999 ? 100 THR F N   1 
ATOM   592  C CA  . THR A 1 104 ? 189.47200 329.92700 -0.98300  1.000 105.63082 ? 100 THR F CA  1 
ATOM   593  C C   . THR A 1 104 ? 190.07000 331.22700 -0.45700  1.000 102.04199 ? 100 THR F C   1 
ATOM   594  O O   . THR A 1 104 ? 191.27600 331.27200 -0.15400  1.000 101.24290 ? 100 THR F O   1 
ATOM   595  C CB  . THR A 1 104 ? 189.75500 328.76000 -0.02600  1.000 106.69655 ? 100 THR F CB  1 
ATOM   596  O OG1 . THR A 1 104 ? 189.27500 327.52800 -0.59300  1.000 99.72246  ? 100 THR F OG1 1 
ATOM   597  C CG2 . THR A 1 104 ? 189.09800 328.99900 1.34200   1.000 99.33299  ? 100 THR F CG2 1 
ATOM   598  N N   . PRO A 1 105 ? 189.27900 332.29600 -0.32000  1.000 102.26617 ? 101 PRO F N   1 
ATOM   599  C CA  . PRO A 1 105 ? 189.83100 333.56700 0.17700   1.000 100.09388 ? 101 PRO F CA  1 
ATOM   600  C C   . PRO A 1 105 ? 190.24800 333.59700 1.64400   1.000 103.94489 ? 101 PRO F C   1 
ATOM   601  O O   . PRO A 1 105 ? 189.60400 333.00100 2.51600   1.000 105.60067 ? 101 PRO F O   1 
ATOM   602  C CB  . PRO A 1 105 ? 188.70000 334.57800 -0.09100  1.000 96.92697  ? 101 PRO F CB  1 
ATOM   603  C CG  . PRO A 1 105 ? 187.81200 333.92600 -1.11400  1.000 100.43239 ? 101 PRO F CG  1 
ATOM   604  C CD  . PRO A 1 105 ? 187.90300 332.44800 -0.82800  1.000 103.07956 ? 101 PRO F CD  1 
ATOM   605  N N   . ALA A 1 106 ? 191.38900 334.25400 1.88600   1.000 96.81586  ? 102 ALA F N   1 
ATOM   606  C CA  . ALA A 1 106 ? 191.89900 334.49100 3.23100   1.000 96.39777  ? 102 ALA F CA  1 
ATOM   607  C C   . ALA A 1 106 ? 191.03000 335.51300 3.96900   1.000 100.07184 ? 102 ALA F C   1 
ATOM   608  O O   . ALA A 1 106 ? 191.05600 335.56700 5.20400   1.000 109.10335 ? 102 ALA F O   1 
ATOM   609  C CB  . ALA A 1 106 ? 193.36300 334.94300 3.18300   1.000 89.44950  ? 102 ALA F CB  1 
ATOM   610  N N   . THR A 1 107 ? 190.29000 336.34100 3.20600   1.000 98.88429  ? 103 THR F N   1 
ATOM   611  C CA  . THR A 1 107 ? 189.42500 337.42600 3.69700   1.000 106.40151 ? 103 THR F CA  1 
ATOM   612  C C   . THR A 1 107 ? 188.39200 337.06300 4.76300   1.000 108.41904 ? 103 THR F C   1 
ATOM   613  O O   . THR A 1 107 ? 187.86600 337.97500 5.41500   1.000 111.45340 ? 103 THR F O   1 
ATOM   614  C CB  . THR A 1 107 ? 188.69200 338.10900 2.52300   1.000 95.47104  ? 103 THR F CB  1 
ATOM   615  O OG1 . THR A 1 107 ? 187.88100 337.16400 1.79600   1.000 100.22901 ? 103 THR F OG1 1 
ATOM   616  C CG2 . THR A 1 107 ? 189.67000 338.77300 1.62100   1.000 69.92414  ? 103 THR F CG2 1 
ATOM   617  N N   . GLY A 1 108 ? 188.08000 335.79800 4.99100   1.000 102.08820 ? 143 GLY F N   1 
ATOM   618  C CA  . GLY A 1 108 ? 187.17600 335.53000 6.08400   1.000 101.81613 ? 143 GLY F CA  1 
ATOM   619  C C   . GLY A 1 108 ? 187.93300 335.82500 7.36800   1.000 104.09275 ? 143 GLY F C   1 
ATOM   620  O O   . GLY A 1 108 ? 189.11200 336.18700 7.35900   1.000 108.37147 ? 143 GLY F O   1 
ATOM   621  N N   . SER A 1 109 ? 187.25200 335.68000 8.49900   1.000 97.89643  ? 144 SER F N   1 
ATOM   622  C CA  . SER A 1 109 ? 187.90800 335.90000 9.78900   1.000 94.17337  ? 144 SER F CA  1 
ATOM   623  C C   . SER A 1 109 ? 188.28200 334.47700 10.15000  1.000 86.23556  ? 144 SER F C   1 
ATOM   624  O O   . SER A 1 109 ? 187.43400 333.68900 10.57900  1.000 80.78331  ? 144 SER F O   1 
ATOM   625  C CB  . SER A 1 109 ? 187.01500 336.55600 10.84300  1.000 94.99743  ? 144 SER F CB  1 
ATOM   626  O OG  . SER A 1 109 ? 187.37000 336.14000 12.16900  1.000 75.25946  ? 144 SER F OG  1 
ATOM   627  N N   . GLY A 1 110 ? 189.56600 334.15400 9.97200   1.000 83.55880  ? 145 GLY F N   1 
ATOM   628  C CA  . GLY A 1 110 ? 190.00300 332.79600 10.20600  1.000 72.13023  ? 145 GLY F CA  1 
ATOM   629  C C   . GLY A 1 110 ? 189.78800 332.35100 11.63000  1.000 69.10449  ? 145 GLY F C   1 
ATOM   630  O O   . GLY A 1 110 ? 189.43200 331.18900 11.87000  1.000 75.45918  ? 145 GLY F O   1 
ATOM   631  N N   . SER A 1 111 ? 189.81900 333.28800 12.57100  1.000 57.21105  ? 146 SER F N   1 
ATOM   632  C CA  . SER A 1 111 ? 189.59400 332.82600 13.92000  1.000 60.59228  ? 146 SER F CA  1 
ATOM   633  C C   . SER A 1 111 ? 188.16900 332.45200 14.21000  1.000 62.93310  ? 146 SER F C   1 
ATOM   634  O O   . SER A 1 111 ? 187.94900 331.79400 15.23400  1.000 69.75634  ? 146 SER F O   1 
ATOM   635  C CB  . SER A 1 111 ? 190.00500 333.86100 14.96500  1.000 53.73322  ? 146 SER F CB  1 
ATOM   636  O OG  . SER A 1 111 ? 189.71600 333.30900 16.25300  1.000 47.29863  ? 146 SER F OG  1 
ATOM   637  N N   . ALA A 1 112 ? 187.22000 332.61200 13.32200  1.000 55.48462  ? 147 ALA F N   1 
ATOM   638  C CA  . ALA A 1 112 ? 185.90500 332.23200 13.77600  1.000 58.86219  ? 147 ALA F CA  1 
ATOM   639  C C   . ALA A 1 112 ? 185.37600 331.13700 12.90100  1.000 55.11752  ? 147 ALA F C   1 
ATOM   640  O O   . ALA A 1 112 ? 184.36900 330.52500 13.25300  1.000 55.35234  ? 147 ALA F O   1 
ATOM   641  C CB  . ALA A 1 112 ? 184.93600 333.42000 13.74300  1.000 52.16264  ? 147 ALA F CB  1 
ATOM   642  N N   . ILE A 1 113 ? 186.12800 330.76900 11.86800  1.000 52.94914  ? 148 ILE F N   1 
ATOM   643  C CA  . ILE A 1 113 ? 185.74700 329.70300 10.96400  1.000 57.88676  ? 148 ILE F CA  1 
ATOM   644  C C   . ILE A 1 113 ? 186.77800 328.60200 11.01100  1.000 52.61667  ? 148 ILE F C   1 
ATOM   645  O O   . ILE A 1 113 ? 186.67600 327.64600 10.25200  1.000 56.96169  ? 148 ILE F O   1 
ATOM   646  C CB  . ILE A 1 113 ? 185.51400 330.16400 9.51100   1.000 52.31134  ? 148 ILE F CB  1 
ATOM   647  C CG1 . ILE A 1 113 ? 186.77800 330.75800 8.89400   1.000 52.77139  ? 148 ILE F CG1 1 
ATOM   648  C CG2 . ILE A 1 113 ? 184.32700 331.11500 9.48200   1.000 49.94001  ? 148 ILE F CG2 1 
ATOM   649  C CD1 . ILE A 1 113 ? 186.60000 331.18900 7.46800   1.000 52.78481  ? 148 ILE F CD1 1 
ATOM   650  N N   . ALA A 1 114 ? 187.78700 328.74900 11.87700  1.000 51.64158  ? 149 ALA F N   1 
ATOM   651  C CA  . ALA A 1 114 ? 188.91900 327.83600 11.93200  1.000 55.14526  ? 149 ALA F CA  1 
ATOM   652  C C   . ALA A 1 114 ? 188.48900 326.38600 12.10300  1.000 47.94608  ? 149 ALA F C   1 
ATOM   653  O O   . ALA A 1 114 ? 189.11400 325.48900 11.53100  1.000 51.34416  ? 149 ALA F O   1 
ATOM   654  C CB  . ALA A 1 114 ? 189.85100 328.24900 13.06900  1.000 48.74271  ? 149 ALA F CB  1 
ATOM   655  N N   . SER A 1 115 ? 187.45500 326.12800 12.90400  1.000 44.88306  ? 150 SER F N   1 
ATOM   656  C CA  . SER A 1 115 ? 186.93100 324.76700 13.02500  1.000 53.65355  ? 150 SER F CA  1 
ATOM   657  C C   . SER A 1 115 ? 186.52900 324.21600 11.66500  1.000 60.61954  ? 150 SER F C   1 
ATOM   658  O O   . SER A 1 115 ? 187.10600 323.23000 11.16500  1.000 63.51197  ? 150 SER F O   1 
ATOM   659  C CB  . SER A 1 115 ? 185.71300 324.74400 13.94200  1.000 53.66597  ? 150 SER F CB  1 
ATOM   660  O OG  . SER A 1 115 ? 186.00700 325.28400 15.20600  1.000 61.44992  ? 150 SER F OG  1 
ATOM   661  N N   . GLY A 1 116 ? 185.51000 324.83500 11.05900  1.000 55.72074  ? 151 GLY F N   1 
ATOM   662  C CA  . GLY A 1 116 ? 185.02200 324.32300 9.79500   1.000 57.49465  ? 151 GLY F CA  1 
ATOM   663  C C   . GLY A 1 116 ? 186.11700 324.26400 8.75200   1.000 58.20939  ? 151 GLY F C   1 
ATOM   664  O O   . GLY A 1 116 ? 186.15200 323.33900 7.94200   1.000 63.43714  ? 151 GLY F O   1 
ATOM   665  N N   . VAL A 1 117 ? 187.04200 325.23100 8.76500   1.000 54.87128  ? 152 VAL F N   1 
ATOM   666  C CA  . VAL A 1 117 ? 188.13100 325.16500 7.79200   1.000 56.77912  ? 152 VAL F CA  1 
ATOM   667  C C   . VAL A 1 117 ? 188.99600 323.93400 8.03500   1.000 61.80600  ? 152 VAL F C   1 
ATOM   668  O O   . VAL A 1 117 ? 189.53700 323.34700 7.08600   1.000 62.90217  ? 152 VAL F O   1 
ATOM   669  C CB  . VAL A 1 117 ? 188.94600 326.47100 7.79200   1.000 56.47465  ? 152 VAL F CB  1 
ATOM   670  C CG1 . VAL A 1 117 ? 190.26100 326.29000 7.07800   1.000 51.57605  ? 152 VAL F CG1 1 
ATOM   671  C CG2 . VAL A 1 117 ? 188.14800 327.57100 7.09900   1.000 46.99414  ? 152 VAL F CG2 1 
ATOM   672  N N   . ALA A 1 118 ? 189.19400 323.54700 9.31500   1.000 60.16264  ? 153 ALA F N   1 
ATOM   673  C CA  . ALA A 1 118 ? 189.95700 322.32300 9.56500   1.000 63.55596  ? 153 ALA F CA  1 
ATOM   674  C C   . ALA A 1 118 ? 189.22000 321.09700 9.02800   1.000 60.57499  ? 153 ALA F C   1 
ATOM   675  O O   . ALA A 1 118 ? 189.84300 320.17800 8.46800   1.000 62.68299  ? 153 ALA F O   1 
ATOM   676  C CB  . ALA A 1 118 ? 190.23600 322.17400 11.06500  1.000 57.59722  ? 153 ALA F CB  1 
ATOM   677  N N   . VAL A 1 119 ? 187.88400 321.15500 9.03100   1.000 62.63333  ? 154 VAL F N   1 
ATOM   678  C CA  . VAL A 1 119 ? 187.12300 320.01500 8.51300   1.000 64.45055  ? 154 VAL F CA  1 
ATOM   679  C C   . VAL A 1 119 ? 187.18100 319.99200 6.99200   1.000 68.88760  ? 154 VAL F C   1 
ATOM   680  O O   . VAL A 1 119 ? 187.27500 318.92900 6.37700   1.000 72.90952  ? 154 VAL F O   1 
ATOM   681  C CB  . VAL A 1 119 ? 185.66700 320.02500 9.00600   1.000 63.47034  ? 154 VAL F CB  1 
ATOM   682  C CG1 . VAL A 1 119 ? 184.96300 318.78300 8.51800   1.000 70.15516  ? 154 VAL F CG1 1 
ATOM   683  C CG2 . VAL A 1 119 ? 185.61100 320.03700 10.52500  1.000 60.12711  ? 154 VAL F CG2 1 
ATOM   684  N N   . CYS A 1 120 ? 187.14500 321.16600 6.36400   1.000 69.36613  ? 155 CYS F N   1 
ATOM   685  C CA  . CYS A 1 120 ? 187.24200 321.21900 4.91600   1.000 67.79904  ? 155 CYS F CA  1 
ATOM   686  C C   . CYS A 1 120 ? 188.61200 320.74600 4.47800   1.000 70.32301  ? 155 CYS F C   1 
ATOM   687  O O   . CYS A 1 120 ? 188.75500 320.16100 3.40000   1.000 74.65450  ? 155 CYS F O   1 
ATOM   688  C CB  . CYS A 1 120 ? 186.98700 322.63600 4.39100   1.000 64.95188  ? 155 CYS F CB  1 
ATOM   689  S SG  . CYS A 1 120 ? 185.24700 323.26500 4.41000   1.000 81.16344  ? 155 CYS F SG  1 
ATOM   690  N N   . LYS A 1 121 ? 189.64500 321.01400 5.27900   1.000 69.47431  ? 156 LYS F N   1 
ATOM   691  C CA  . LYS A 1 121 ? 190.95200 320.53000 4.86700   1.000 71.34584  ? 156 LYS F CA  1 
ATOM   692  C C   . LYS A 1 121 ? 190.99200 319.01100 4.95200   1.000 75.95890  ? 156 LYS F C   1 
ATOM   693  O O   . LYS A 1 121 ? 191.70600 318.35900 4.18300   1.000 77.97810  ? 156 LYS F O   1 
ATOM   694  C CB  . LYS A 1 121 ? 192.03900 321.16300 5.74200   1.000 67.94056  ? 156 LYS F CB  1 
ATOM   695  C CG  . LYS A 1 121 ? 193.40400 321.29400 5.07500   1.000 73.01785  ? 156 LYS F CG  1 
ATOM   696  C CD  . LYS A 1 121 ? 194.54300 321.29400 6.09900   1.000 72.69352  ? 156 LYS F CD  1 
ATOM   697  C CE  . LYS A 1 121 ? 194.79100 322.69900 6.62500   1.000 73.78400  ? 156 LYS F CE  1 
ATOM   698  N NZ  . LYS A 1 121 ? 196.21200 323.12100 6.47500   1.000 80.19184  ? 156 LYS F NZ  1 
ATOM   699  N N   . VAL A 1 122 ? 190.22800 318.43200 5.87700   1.000 73.38627  ? 157 VAL F N   1 
ATOM   700  C CA  . VAL A 1 122 ? 190.16400 316.97000 5.95500   1.000 82.97208  ? 157 VAL F CA  1 
ATOM   701  C C   . VAL A 1 122 ? 189.37200 316.39800 4.78300   1.000 84.87041  ? 157 VAL F C   1 
ATOM   702  O O   . VAL A 1 122 ? 189.72100 315.35200 4.21700   1.000 88.86241  ? 157 VAL F O   1 
ATOM   703  C CB  . VAL A 1 122 ? 189.60700 316.49200 7.30400   1.000 81.05459  ? 157 VAL F CB  1 
ATOM   704  C CG1 . VAL A 1 122 ? 189.50600 314.96100 7.29800   1.000 90.19811  ? 157 VAL F CG1 1 
ATOM   705  C CG2 . VAL A 1 122 ? 190.50400 316.99500 8.43800   1.000 78.51884  ? 157 VAL F CG2 1 
ATOM   706  N N   . LEU A 1 123 ? 188.31300 317.09800 4.38900   1.000 81.84070  ? 158 LEU F N   1 
ATOM   707  C CA  . LEU A 1 123 ? 187.44200 316.64400 3.31900   1.000 77.37859  ? 158 LEU F CA  1 
ATOM   708  C C   . LEU A 1 123 ? 188.17900 316.59600 1.99400   1.000 77.67842  ? 158 LEU F C   1 
ATOM   709  O O   . LEU A 1 123 ? 187.85200 315.77300 1.13600   1.000 88.40757  ? 158 LEU F O   1 
ATOM   710  C CB  . LEU A 1 123 ? 186.23800 317.58300 3.27600   1.000 77.52547  ? 158 LEU F CB  1 
ATOM   711  C CG  . LEU A 1 123 ? 185.11800 317.04300 4.16700   1.000 69.80286  ? 158 LEU F CG  1 
ATOM   712  C CD1 . LEU A 1 123 ? 183.74900 317.57700 3.80000   1.000 72.90357  ? 158 LEU F CD1 1 
ATOM   713  C CD2 . LEU A 1 123 ? 185.14900 315.52500 4.16800   1.000 82.46329  ? 158 LEU F CD2 1 
ATOM   714  N N   . HIS A 1 124 ? 189.18400 317.44500 1.81600   1.000 78.04310  ? 159 HIS F N   1 
ATOM   715  C CA  . HIS A 1 124 ? 189.98600 317.44800 0.60100   1.000 77.51446  ? 159 HIS F CA  1 
ATOM   716  C C   . HIS A 1 124 ? 190.87400 316.21200 0.49800   1.000 85.61396  ? 159 HIS F C   1 
ATOM   717  O O   . HIS A 1 124 ? 191.51400 316.01800 -0.54100  1.000 89.77034  ? 159 HIS F O   1 
ATOM   718  C CB  . HIS A 1 124 ? 190.89600 318.68000 0.55500   1.000 76.51301  ? 159 HIS F CB  1 
ATOM   719  C CG  . HIS A 1 124 ? 190.30900 319.87100 -0.14200  1.000 78.30555  ? 159 HIS F CG  1 
ATOM   720  N ND1 . HIS A 1 124 ? 189.11700 320.44900 0.23800   1.000 76.37676  ? 159 HIS F ND1 1 
ATOM   721  C CD2 . HIS A 1 124 ? 190.78200 320.62500 -1.16300  1.000 78.60834  ? 159 HIS F CD2 1 
ATOM   722  C CE1 . HIS A 1 124 ? 188.86800 321.49200 -0.53400  1.000 75.98805  ? 159 HIS F CE1 1 
ATOM   723  N NE2 . HIS A 1 124 ? 189.86400 321.62200 -1.39200  1.000 75.68987  ? 159 HIS F NE2 1 
ATOM   724  N N   . LEU A 1 125 ? 191.01700 315.43500 1.57400   1.000 88.26325  ? 160 LEU F N   1 
ATOM   725  C CA  . LEU A 1 125 ? 191.78600 314.19600 1.50800   1.000 96.19750  ? 160 LEU F CA  1 
ATOM   726  C C   . LEU A 1 125 ? 191.10600 313.12900 0.66000   1.000 97.82343  ? 160 LEU F C   1 
ATOM   727  O O   . LEU A 1 125 ? 189.87500 312.99200 0.64100   1.000 100.00600 ? 160 LEU F O   1 
ATOM   728  C CB  . LEU A 1 125 ? 192.01600 313.63000 2.91000   1.000 94.09843  ? 160 LEU F CB  1 
ATOM   729  C CG  . LEU A 1 125 ? 192.75600 314.58300 3.84500   1.000 98.73925  ? 160 LEU F CG  1 
ATOM   730  C CD1 . LEU A 1 125 ? 192.97000 313.94500 5.22000   1.000 96.11027  ? 160 LEU F CD1 1 
ATOM   731  C CD2 . LEU A 1 125 ? 194.09000 315.02000 3.20600   1.000 94.04563  ? 160 LEU F CD2 1 
ATOM   732  N N   . GLU A 1 126 ? 191.94000 312.29100 0.05300   1.000 99.98838  ? 161 GLU F N   1 
ATOM   733  C CA  . GLU A 1 126 ? 191.45300 311.22600 -0.80700  1.000 99.54925  ? 161 GLU F CA  1 
ATOM   734  C C   . GLU A 1 126 ? 190.81100 310.14900 0.05100   1.000 97.34253  ? 161 GLU F C   1 
ATOM   735  O O   . GLU A 1 126 ? 191.39600 309.69600 1.03900   1.000 99.51913  ? 161 GLU F O   1 
ATOM   736  C CB  . GLU A 1 126 ? 192.58600 310.64100 -1.64100  1.000 96.46800  ? 161 GLU F CB  1 
ATOM   737  C CG  . GLU A 1 126 ? 193.61100 309.89100 -0.82000  1.000 105.13665 ? 161 GLU F CG  1 
ATOM   738  C CD  . GLU A 1 126 ? 194.10900 308.63700 -1.52700  1.000 114.13435 ? 161 GLU F CD  1 
ATOM   739  O OE1 . GLU A 1 126 ? 193.65000 308.38000 -2.66100  1.000 113.59453 ? 161 GLU F OE1 1 
ATOM   740  O OE2 . GLU A 1 126 ? 194.95500 307.90900 -0.95400  1.000 113.05676 ? 161 GLU F OE2 1 
ATOM   741  N N   . GLY A 1 127 ? 189.58700 309.78400 -0.28400  1.000 93.57959  ? 162 GLY F N   1 
ATOM   742  C CA  . GLY A 1 127 ? 188.88900 308.77000 0.45900   1.000 93.91465  ? 162 GLY F CA  1 
ATOM   743  C C   . GLY A 1 127 ? 187.94100 309.28700 1.51200   1.000 99.02968  ? 162 GLY F C   1 
ATOM   744  O O   . GLY A 1 127 ? 187.11700 308.50900 2.00700   1.000 94.31021  ? 162 GLY F O   1 
ATOM   745  N N   . GLU A 1 128 ? 188.00000 310.57300 1.85300   1.000 97.51008  ? 163 GLU F N   1 
ATOM   746  C CA  . GLU A 1 128 ? 187.11400 311.04300 2.91200   1.000 97.84594  ? 163 GLU F CA  1 
ATOM   747  C C   . GLU A 1 128 ? 185.71700 311.28400 2.35400   1.000 96.99033  ? 163 GLU F C   1 
ATOM   748  O O   . GLU A 1 128 ? 184.69500 310.97700 3.00600   1.000 98.57986  ? 163 GLU F O   1 
ATOM   749  C CB  . GLU A 1 128 ? 187.68100 312.29500 3.58200   1.000 99.86904  ? 163 GLU F CB  1 
ATOM   750  C CG  . GLU A 1 128 ? 188.63100 311.99600 4.77600   1.000 99.63517  ? 163 GLU F CG  1 
ATOM   751  C CD  . GLU A 1 128 ? 187.89400 311.68700 6.10000   1.000 99.36282  ? 163 GLU F CD  1 
ATOM   752  O OE1 . GLU A 1 128 ? 186.94200 312.41700 6.45800   1.000 96.40099  ? 163 GLU F OE1 1 
ATOM   753  O OE2 . GLU A 1 128 ? 188.27300 310.71000 6.79300   1.000 102.40766 ? 163 GLU F OE2 1 
ATOM   754  N N   . VAL A 1 129 ? 185.65000 311.81100 1.13400   1.000 95.72756  ? 164 VAL F N   1 
ATOM   755  C CA  . VAL A 1 129 ? 184.33700 311.92600 0.52900   1.000 97.26193  ? 164 VAL F CA  1 
ATOM   756  C C   . VAL A 1 129 ? 183.75000 310.54100 0.28600   1.000 96.41221  ? 164 VAL F C   1 
ATOM   757  O O   . VAL A 1 129 ? 182.52800 310.36600 0.37100   1.000 98.63052  ? 164 VAL F O   1 
ATOM   758  C CB  . VAL A 1 129 ? 184.43300 312.76700 -0.75200  1.000 95.29647  ? 164 VAL F CB  1 
ATOM   759  C CG1 . VAL A 1 129 ? 184.62300 314.23200 -0.38000  1.000 95.42276  ? 164 VAL F CG1 1 
ATOM   760  C CG2 . VAL A 1 129 ? 185.62200 312.28200 -1.58600  1.000 92.92419  ? 164 VAL F CG2 1 
ATOM   761  N N   . ASN A 1 130 ? 184.59800 309.52000 0.08700   1.000 97.96075  ? 165 ASN F N   1 
ATOM   762  C CA  . ASN A 1 130 ? 184.06600 308.16000 -0.05300  1.000 99.64197  ? 165 ASN F CA  1 
ATOM   763  C C   . ASN A 1 130 ? 183.46500 307.66600 1.25900   1.000 99.51192  ? 165 ASN F C   1 
ATOM   764  O O   . ASN A 1 130 ? 182.46500 306.93000 1.25700   1.000 98.42804  ? 165 ASN F O   1 
ATOM   765  C CB  . ASN A 1 130 ? 185.16500 307.19400 -0.50500  1.000 98.21493  ? 165 ASN F CB  1 
ATOM   766  C CG  . ASN A 1 130 ? 185.86000 307.64900 -1.77000  1.000 102.37822 ? 165 ASN F CG  1 
ATOM   767  O OD1 . ASN A 1 130 ? 185.35000 308.50200 -2.49600  1.000 103.03867 ? 165 ASN F OD1 1 
ATOM   768  N ND2 . ASN A 1 130 ? 187.04000 307.08600 -2.03800  1.000 100.51028 ? 165 ASN F ND2 1 
ATOM   769  N N   . LYS A 1 131 ? 183.96300 308.19100 2.38000   1.000 96.73691  ? 166 LYS F N   1 
ATOM   770  C CA  . LYS A 1 131 ? 183.47300 307.77100 3.68500   1.000 93.47682  ? 166 LYS F CA  1 
ATOM   771  C C   . LYS A 1 131 ? 182.09100 308.35400 3.92300   1.000 97.66411  ? 166 LYS F C   1 
ATOM   772  O O   . LYS A 1 131 ? 181.15600 307.63800 4.31500   1.000 99.45552  ? 166 LYS F O   1 
ATOM   773  C CB  . LYS A 1 131 ? 184.43900 308.20200 4.79300   1.000 96.00157  ? 166 LYS F CB  1 
ATOM   774  C CG  . LYS A 1 131 ? 185.93200 308.30300 4.42600   1.000 96.52807  ? 166 LYS F CG  1 
ATOM   775  C CD  . LYS A 1 131 ? 186.65300 306.96000 4.31200   1.000 94.81170  ? 166 LYS F CD  1 
ATOM   776  C CE  . LYS A 1 131 ? 187.95500 306.93500 5.15000   1.000 90.07990  ? 166 LYS F CE  1 
ATOM   777  N NZ  . LYS A 1 131 ? 189.03200 307.87900 4.71200   1.000 86.77867  ? 166 LYS F NZ  1 
ATOM   778  N N   . ILE A 1 132 ? 181.95700 309.67300 3.75400   1.000 98.88785  ? 167 ILE F N   1 
ATOM   779  C CA  . ILE A 1 132 ? 180.62600 310.26300 3.91800   1.000 99.63346  ? 167 ILE F CA  1 
ATOM   780  C C   . ILE A 1 132 ? 179.64700 309.72300 2.87200   1.000 99.63115  ? 167 ILE F C   1 
ATOM   781  O O   . ILE A 1 132 ? 178.43900 309.57200 3.14700   1.000 94.78000  ? 167 ILE F O   1 
ATOM   782  C CB  . ILE A 1 132 ? 180.72900 311.80400 3.85800   1.000 97.22126  ? 167 ILE F CB  1 
ATOM   783  C CG1 . ILE A 1 132 ? 181.54000 312.21300 2.62500   1.000 99.83540  ? 167 ILE F CG1 1 
ATOM   784  C CG2 . ILE A 1 132 ? 181.25800 312.40600 5.17300   1.000 95.46370  ? 167 ILE F CG2 1 
ATOM   785  C CD1 . ILE A 1 132 ? 181.79100 313.69700 2.52500   1.000 100.09183 ? 167 ILE F CD1 1 
ATOM   786  N N   . LYS A 1 133 ? 180.15600 309.37400 1.68200   1.000 99.64448  ? 168 LYS F N   1 
ATOM   787  C CA  . LYS A 1 133 ? 179.33100 308.81200 0.62000   1.000 98.41646  ? 168 LYS F CA  1 
ATOM   788  C C   . LYS A 1 133 ? 178.81700 307.43100 1.02000   1.000 99.28988  ? 168 LYS F C   1 
ATOM   789  O O   . LYS A 1 133 ? 177.71000 307.03400 0.63200   1.000 98.80919  ? 168 LYS F O   1 
ATOM   790  C CB  . LYS A 1 133 ? 180.18200 308.79500 -0.65200  1.000 94.71454  ? 168 LYS F CB  1 
ATOM   791  C CG  . LYS A 1 133 ? 179.44600 308.90200 -1.96900  1.000 94.78469  ? 168 LYS F CG  1 
ATOM   792  C CD  . LYS A 1 133 ? 180.48700 308.97600 -3.08000  1.000 88.88650  ? 168 LYS F CD  1 
ATOM   793  C CE  . LYS A 1 133 ? 179.86700 309.19100 -4.43600  1.000 86.69601  ? 168 LYS F CE  1 
ATOM   794  N NZ  . LYS A 1 133 ? 180.96700 309.27000 -5.43100  1.000 91.06138  ? 168 LYS F NZ  1 
ATOM   795  N N   . SER A 1 134 ? 179.56300 306.73800 1.88700   1.000 99.91602  ? 169 SER F N   1 
ATOM   796  C CA  . SER A 1 134 ? 179.12000 305.43200 2.35100   1.000 96.19096  ? 169 SER F CA  1 
ATOM   797  C C   . SER A 1 134 ? 178.14900 305.57100 3.51300   1.000 100.68778 ? 169 SER F C   1 
ATOM   798  O O   . SER A 1 134 ? 177.15800 304.83400 3.58300   1.000 103.73034 ? 169 SER F O   1 
ATOM   799  C CB  . SER A 1 134 ? 180.32100 304.59900 2.79200   1.000 89.73425  ? 169 SER F CB  1 
ATOM   800  O OG  . SER A 1 134 ? 181.25800 304.46000 1.73900   1.000 89.23644  ? 169 SER F OG  1 
ATOM   801  N N   . ALA A 1 135 ? 178.39000 306.52700 4.41700   1.000 96.71449  ? 170 ALA F N   1 
ATOM   802  C CA  . ALA A 1 135 ? 177.47900 306.65200 5.55300   1.000 96.82859  ? 170 ALA F CA  1 
ATOM   803  C C   . ALA A 1 135 ? 176.10300 307.14900 5.11800   1.000 100.05917 ? 170 ALA F C   1 
ATOM   804  O O   . ALA A 1 135 ? 175.07800 306.70400 5.65400   1.000 96.94539  ? 170 ALA F O   1 
ATOM   805  C CB  . ALA A 1 135 ? 178.07300 307.58600 6.60600   1.000 99.62031  ? 170 ALA F CB  1 
ATOM   806  N N   . LEU A 1 136 ? 176.04100 308.05900 4.13600   1.000 100.64316 ? 171 LEU F N   1 
ATOM   807  C CA  . LEU A 1 136 ? 174.73000 308.49000 3.66100   1.000 100.96135 ? 171 LEU F CA  1 
ATOM   808  C C   . LEU A 1 136 ? 174.27100 307.65600 2.48300   1.000 103.32200 ? 171 LEU F C   1 
ATOM   809  O O   . LEU A 1 136 ? 173.55600 308.15000 1.59500   1.000 100.74342 ? 171 LEU F O   1 
ATOM   810  C CB  . LEU A 1 136 ? 174.70900 309.98400 3.32700   1.000 99.30618  ? 171 LEU F CB  1 
ATOM   811  C CG  . LEU A 1 136 ? 174.91800 310.97100 4.48200   1.000 91.46946  ? 171 LEU F CG  1 
ATOM   812  C CD1 . LEU A 1 136 ? 174.86000 312.41100 3.97400   1.000 85.32402  ? 171 LEU F CD1 1 
ATOM   813  C CD2 . LEU A 1 136 ? 173.87400 310.73800 5.58100   1.000 87.81310  ? 171 LEU F CD2 1 
ATOM   814  N N   . LEU A 1 137 ? 174.62500 306.37300 2.49400   1.000 104.43829 ? 172 LEU F N   1 
ATOM   815  C CA  . LEU A 1 137 ? 174.26100 305.47800 1.41200   1.000 105.43380 ? 172 LEU F CA  1 
ATOM   816  C C   . LEU A 1 137 ? 172.82100 305.01100 1.57000   1.000 105.77290 ? 172 LEU F C   1 
ATOM   817  O O   . LEU A 1 137 ? 172.12100 304.83200 0.56700   1.000 102.19418 ? 172 LEU F O   1 
ATOM   818  C CB  . LEU A 1 137 ? 175.25800 304.31500 1.37700   1.000 103.08587 ? 172 LEU F CB  1 
ATOM   819  C CG  . LEU A 1 137 ? 175.21100 303.20500 0.33800   1.000 100.79285 ? 172 LEU F CG  1 
ATOM   820  C CD1 . LEU A 1 137 ? 175.45100 303.79200 -1.03900  1.000 95.45808  ? 172 LEU F CD1 1 
ATOM   821  C CD2 . LEU A 1 137 ? 176.29700 302.18900 0.66400   1.000 101.80938 ? 172 LEU F CD2 1 
ATOM   822  N N   . SER A 1 138 ? 172.34300 304.88100 2.81500   1.000 108.87291 ? 173 SER F N   1 
ATOM   823  C CA  . SER A 1 138 ? 171.00800 304.35900 3.07100   1.000 108.11873 ? 173 SER F CA  1 
ATOM   824  C C   . SER A 1 138 ? 170.08100 305.33900 3.78500   1.000 108.85828 ? 173 SER F C   1 
ATOM   825  O O   . SER A 1 138 ? 168.86000 305.20100 3.65900   1.000 107.63453 ? 173 SER F O   1 
ATOM   826  C CB  . SER A 1 138 ? 171.11400 303.07700 3.90900   1.000 110.36782 ? 173 SER F CB  1 
ATOM   827  O OG  . SER A 1 138 ? 171.63300 302.01900 3.12100   1.000 112.32133 ? 173 SER F OG  1 
ATOM   828  N N   . THR A 1 139 ? 170.61300 306.29800 4.55100   1.000 111.11696 ? 174 THR F N   1 
ATOM   829  C CA  . THR A 1 139 ? 169.80300 307.23800 5.32500   1.000 105.51893 ? 174 THR F CA  1 
ATOM   830  C C   . THR A 1 139 ? 170.19900 308.67100 4.96000   1.000 103.32579 ? 174 THR F C   1 
ATOM   831  O O   . THR A 1 139 ? 171.23100 308.91600 4.32100   1.000 99.38758  ? 174 THR F O   1 
ATOM   832  C CB  . THR A 1 139 ? 169.90900 306.98300 6.84100   1.000 102.13998 ? 174 THR F CB  1 
ATOM   833  O OG1 . THR A 1 139 ? 171.28500 307.01600 7.24400   1.000 105.78213 ? 174 THR F OG1 1 
ATOM   834  C CG2 . THR A 1 139 ? 169.27200 305.64300 7.22600   1.000 104.35726 ? 174 THR F CG2 1 
ATOM   835  N N   . ASN A 1 140 ? 169.36500 309.62800 5.38800   1.000 102.98297 ? 175 ASN F N   1 
ATOM   836  C CA  . ASN A 1 140 ? 169.64500 311.05200 5.18000   1.000 101.88831 ? 175 ASN F CA  1 
ATOM   837  C C   . ASN A 1 140 ? 170.62100 311.62500 6.20600   1.000 96.81733  ? 175 ASN F C   1 
ATOM   838  O O   . ASN A 1 140 ? 171.44300 312.48400 5.86400   1.000 90.83283  ? 175 ASN F O   1 
ATOM   839  C CB  . ASN A 1 140 ? 168.35400 311.86600 5.15400   1.000 102.91612 ? 175 ASN F CB  1 
ATOM   840  C CG  . ASN A 1 140 ? 167.43200 311.43500 4.04300   1.000 108.48785 ? 175 ASN F CG  1 
ATOM   841  O OD1 . ASN A 1 140 ? 167.88900 310.96100 2.99500   1.000 105.21062 ? 175 ASN F OD1 1 
ATOM   842  N ND2 . ASN A 1 140 ? 166.12900 311.62400 4.24400   1.000 109.59605 ? 175 ASN F ND2 1 
ATOM   843  N N   . LYS A 1 141 ? 170.52200 311.20800 7.46600   1.000 97.36086  ? 176 LYS F N   1 
ATOM   844  C CA  . LYS A 1 141 ? 171.39000 311.71600 8.51900   1.000 93.07038  ? 176 LYS F CA  1 
ATOM   845  C C   . LYS A 1 141 ? 172.29400 310.59300 9.00300   1.000 88.22630  ? 176 LYS F C   1 
ATOM   846  O O   . LYS A 1 141 ? 171.89500 309.42700 9.04100   1.000 92.81398  ? 176 LYS F O   1 
ATOM   847  C CB  . LYS A 1 141 ? 170.57600 312.26400 9.70400   1.000 87.54534  ? 176 LYS F CB  1 
ATOM   848  C CG  . LYS A 1 141 ? 169.35600 313.11500 9.32400   1.000 95.53902  ? 176 LYS F CG  1 
ATOM   849  C CD  . LYS A 1 141 ? 168.75700 313.85200 10.54400  1.000 92.84603  ? 176 LYS F CD  1 
ATOM   850  C CE  . LYS A 1 141 ? 167.67900 313.04000 11.26900  1.000 88.62805  ? 176 LYS F CE  1 
ATOM   851  N NZ  . LYS A 1 141 ? 168.21700 311.88800 12.06000  1.000 80.75609  ? 176 LYS F NZ  1 
ATOM   852  N N   . ALA A 1 142 ? 173.50800 310.95000 9.40900   1.000 83.98726  ? 177 ALA F N   1 
ATOM   853  C CA  . ALA A 1 142 ? 174.38700 309.88700 9.87800   1.000 83.84469  ? 177 ALA F CA  1 
ATOM   854  C C   . ALA A 1 142 ? 175.60300 310.49500 10.55000  1.000 87.73572  ? 177 ALA F C   1 
ATOM   855  O O   . ALA A 1 142 ? 176.11300 311.51700 10.09500  1.000 88.79831  ? 177 ALA F O   1 
ATOM   856  C CB  . ALA A 1 142 ? 174.82200 308.98100 8.72200   1.000 81.41589  ? 177 ALA F CB  1 
ATOM   857  N N   . VAL A 1 143 ? 176.06800 309.86500 11.62300  1.000 88.15916  ? 178 VAL F N   1 
ATOM   858  C CA  . VAL A 1 143 ? 177.28900 310.31100 12.28300  1.000 85.46319  ? 178 VAL F CA  1 
ATOM   859  C C   . VAL A 1 143 ? 178.47400 309.67900 11.57000  1.000 81.24674  ? 178 VAL F C   1 
ATOM   860  O O   . VAL A 1 143 ? 178.46100 308.48800 11.25300  1.000 92.68922  ? 178 VAL F O   1 
ATOM   861  C CB  . VAL A 1 143 ? 177.28100 309.94200 13.78000  1.000 85.25072  ? 178 VAL F CB  1 
ATOM   862  C CG1 . VAL A 1 143 ? 178.50400 310.55100 14.48600  1.000 81.02579  ? 178 VAL F CG1 1 
ATOM   863  C CG2 . VAL A 1 143 ? 175.96400 310.35900 14.44600  1.000 75.25080  ? 178 VAL F CG2 1 
ATOM   864  N N   . VAL A 1 144 ? 179.50000 310.47500 11.30700  1.000 78.21506  ? 179 VAL F N   1 
ATOM   865  C CA  . VAL A 1 144 ? 180.68200 310.01900 10.59300  1.000 86.23314  ? 179 VAL F CA  1 
ATOM   866  C C   . VAL A 1 144 ? 181.90400 310.43600 11.39000  1.000 91.87314  ? 179 VAL F C   1 
ATOM   867  O O   . VAL A 1 144 ? 182.04500 311.61200 11.75900  1.000 95.35075  ? 179 VAL F O   1 
ATOM   868  C CB  . VAL A 1 144 ? 180.76600 310.57100 9.16000   1.000 88.67333  ? 179 VAL F CB  1 
ATOM   869  C CG1 . VAL A 1 144 ? 182.05500 310.08400 8.49600   1.000 88.99876  ? 179 VAL F CG1 1 
ATOM   870  C CG2 . VAL A 1 144 ? 179.54500 310.15700 8.35900   1.000 84.19802  ? 179 VAL F CG2 1 
ATOM   871  N N   . SER A 1 145 ? 182.77000 309.47200 11.66700  1.000 93.97355  ? 180 SER F N   1 
ATOM   872  C CA  . SER A 1 145 ? 184.04900 309.72500 12.31900  1.000 99.79368  ? 180 SER F CA  1 
ATOM   873  C C   . SER A 1 145 ? 185.08300 309.98400 11.22900  1.000 95.86471  ? 180 SER F C   1 
ATOM   874  O O   . SER A 1 145 ? 185.40800 309.09200 10.43800  1.000 95.44286  ? 180 SER F O   1 
ATOM   875  C CB  . SER A 1 145 ? 184.45500 308.55700 13.21500  1.000 99.88494  ? 180 SER F CB  1 
ATOM   876  O OG  . SER A 1 145 ? 184.19400 307.31300 12.58600  1.000 105.79460 ? 180 SER F OG  1 
ATOM   877  N N   . LEU A 1 146 ? 185.54900 311.22300 11.14300  1.000 95.56862  ? 181 LEU F N   1 
ATOM   878  C CA  . LEU A 1 146 ? 186.50100 311.57400 10.10800  1.000 98.66445  ? 181 LEU F CA  1 
ATOM   879  C C   . LEU A 1 146 ? 187.89100 311.05600 10.51200  1.000 99.68098  ? 181 LEU F C   1 
ATOM   880  O O   . LEU A 1 146 ? 188.09200 310.55600 11.62500  1.000 102.00775 ? 181 LEU F O   1 
ATOM   881  C CB  . LEU A 1 146 ? 186.46200 313.09300 9.91600   1.000 100.26620 ? 181 LEU F CB  1 
ATOM   882  C CG  . LEU A 1 146 ? 185.02900 313.68400 9.85800   1.000 96.54614  ? 181 LEU F CG  1 
ATOM   883  C CD1 . LEU A 1 146 ? 184.98300 315.20900 9.97500   1.000 80.56440  ? 181 LEU F CD1 1 
ATOM   884  C CD2 . LEU A 1 146 ? 184.28300 313.23700 8.60300   1.000 91.18999  ? 181 LEU F CD2 1 
ATOM   885  N N   . SER A 1 147 ? 188.88800 311.22000 9.63000   1.000 98.72347  ? 182 SER F N   1 
ATOM   886  C CA  . SER A 1 147 ? 190.25600 310.77400 9.90100   1.000 96.51144  ? 182 SER F CA  1 
ATOM   887  C C   . SER A 1 147 ? 191.08800 311.82400 10.64800  1.000 101.47836 ? 182 SER F C   1 
ATOM   888  O O   . SER A 1 147 ? 192.32400 311.86100 10.51000  1.000 100.91406 ? 182 SER F O   1 
ATOM   889  C CB  . SER A 1 147 ? 190.94900 310.35600 8.60400   1.000 89.97635  ? 182 SER F CB  1 
ATOM   890  O OG  . SER A 1 147 ? 191.02600 311.42300 7.68700   1.000 91.05283  ? 182 SER F OG  1 
ATOM   891  N N   . ASN A 1 148 ? 190.43000 312.67800 11.44300  1.000 97.40696  ? 183 ASN F N   1 
ATOM   892  C CA  . ASN A 1 148 ? 191.11100 313.69000 12.23700  1.000 91.83717  ? 183 ASN F CA  1 
ATOM   893  C C   . ASN A 1 148 ? 190.54800 313.76300 13.64800  1.000 93.16925  ? 183 ASN F C   1 
ATOM   894  O O   . ASN A 1 148 ? 190.82700 314.73700 14.36300  1.000 86.99185  ? 183 ASN F O   1 
ATOM   895  C CB  . ASN A 1 148 ? 190.96200 315.06000 11.57700  1.000 91.51341  ? 183 ASN F CB  1 
ATOM   896  C CG  . ASN A 1 148 ? 189.52700 315.57800 11.65000  1.000 94.22006  ? 183 ASN F CG  1 
ATOM   897  O OD1 . ASN A 1 148 ? 188.57400 314.79100 11.66100  1.000 90.85079  ? 183 ASN F OD1 1 
ATOM   898  N ND2 . ASN A 1 148 ? 189.36600 316.90100 11.69000  1.000 88.83925  ? 183 ASN F ND2 1 
ATOM   899  N N   . GLY A 1 149 ? 189.76600 312.77200 14.06800  1.000 95.89165  ? 184 GLY F N   1 
ATOM   900  C CA  . GLY A 1 149 ? 189.22600 312.73200 15.41200  1.000 98.43057  ? 184 GLY F CA  1 
ATOM   901  C C   . GLY A 1 149 ? 187.95300 313.52000 15.64700  1.000 98.49483  ? 184 GLY F C   1 
ATOM   902  O O   . GLY A 1 149 ? 187.50500 313.60400 16.79700  1.000 97.84216  ? 184 GLY F O   1 
ATOM   903  N N   . VAL A 1 150 ? 187.35000 314.09200 14.60800  1.000 100.90533 ? 185 VAL F N   1 
ATOM   904  C CA  . VAL A 1 150 ? 186.13200 314.88800 14.73900  1.000 95.74616  ? 185 VAL F CA  1 
ATOM   905  C C   . VAL A 1 150 ? 184.95800 313.99200 14.35200  1.000 93.97643  ? 185 VAL F C   1 
ATOM   906  O O   . VAL A 1 150 ? 184.87500 313.50400 13.21600  1.000 88.58468  ? 185 VAL F O   1 
ATOM   907  C CB  . VAL A 1 150 ? 186.18300 316.18000 13.90700  1.000 97.62914  ? 185 VAL F CB  1 
ATOM   908  C CG1 . VAL A 1 150 ? 184.89600 316.97900 14.11000  1.000 90.75633  ? 185 VAL F CG1 1 
ATOM   909  C CG2 . VAL A 1 150 ? 187.40400 317.03200 14.29800  1.000 89.65587  ? 185 VAL F CG2 1 
ATOM   910  N N   . SER A 1 151 ? 184.05600 313.78600 15.31400  1.000 94.66514  ? 186 SER F N   1 
ATOM   911  C CA  . SER A 1 151 ? 182.81900 313.02000 15.14900  1.000 95.32181  ? 186 SER F CA  1 
ATOM   912  C C   . SER A 1 151 ? 181.71600 313.95800 14.68100  1.000 94.76858  ? 186 SER F C   1 
ATOM   913  O O   . SER A 1 151 ? 180.97900 314.54300 15.48300  1.000 89.72907  ? 186 SER F O   1 
ATOM   914  C CB  . SER A 1 151 ? 182.43000 312.34100 16.45700  1.000 95.11310  ? 186 SER F CB  1 
ATOM   915  O OG  . SER A 1 151 ? 181.29400 311.51000 16.28400  1.000 93.62646  ? 186 SER F OG  1 
ATOM   916  N N   . VAL A 1 152 ? 181.62200 314.12700 13.32800  1.000 93.27762  ? 187 VAL F N   1 
ATOM   917  C CA  . VAL A 1 152 ? 180.70700 315.10200 12.75300  1.000 85.27584  ? 187 VAL F CA  1 
ATOM   918  C C   . VAL A 1 152 ? 179.37700 314.45600 12.40800  1.000 80.45292  ? 187 VAL F C   1 
ATOM   919  O O   . VAL A 1 152 ? 179.28000 313.26100 12.12300  1.000 84.39797  ? 187 VAL F O   1 
ATOM   920  C CB  . VAL A 1 152 ? 181.33900 315.69600 11.48400  1.000 82.61602  ? 187 VAL F CB  1 
ATOM   921  C CG1 . VAL A 1 152 ? 181.10000 314.73900 10.32800  1.000 81.56646  ? 187 VAL F CG1 1 
ATOM   922  C CG2 . VAL A 1 152 ? 180.73700 317.03700 11.18100  1.000 77.71138  ? 187 VAL F CG2 1 
ATOM   923  N N   . LEU A 1 153 ? 178.33500 315.27000 12.39000  1.000 76.09362  ? 188 LEU F N   1 
ATOM   924  C CA  . LEU A 1 153 ? 177.01500 314.80300 12.01400  1.000 75.66101  ? 188 LEU F CA  1 
ATOM   925  C C   . LEU A 1 153 ? 176.79900 315.26600 10.57300  1.000 82.55360  ? 188 LEU F C   1 
ATOM   926  O O   . LEU A 1 153 ? 176.92100 316.46600 10.27100  1.000 78.67519  ? 188 LEU F O   1 
ATOM   927  C CB  . LEU A 1 153 ? 175.96500 315.33900 12.98800  1.000 71.62022  ? 188 LEU F CB  1 
ATOM   928  C CG  . LEU A 1 153 ? 174.48900 314.99500 12.84200  1.000 79.65656  ? 188 LEU F CG  1 
ATOM   929  C CD1 . LEU A 1 153 ? 174.34000 313.49100 12.79900  1.000 85.55256  ? 188 LEU F CD1 1 
ATOM   930  C CD2 . LEU A 1 153 ? 173.71500 315.53700 14.03800  1.000 77.21270  ? 188 LEU F CD2 1 
ATOM   931  N N   . THR A 1 154 ? 176.57600 314.31500 9.66700   1.000 83.00718  ? 189 THR F N   1 
ATOM   932  C CA  . THR A 1 154 ? 176.44800 314.60500 8.25100   1.000 77.99033  ? 189 THR F CA  1 
ATOM   933  C C   . THR A 1 154 ? 174.98800 314.46800 7.85500   1.000 81.45073  ? 189 THR F C   1 
ATOM   934  O O   . THR A 1 154 ? 174.21300 313.72900 8.48000   1.000 84.54457  ? 189 THR F O   1 
ATOM   935  C CB  . THR A 1 154 ? 177.31800 313.68500 7.39600   1.000 72.15234  ? 189 THR F CB  1 
ATOM   936  O OG1 . THR A 1 154 ? 176.89600 312.33600 7.60500   1.000 77.01464  ? 189 THR F OG1 1 
ATOM   937  C CG2 . THR A 1 154 ? 178.79800 313.82700 7.76000   1.000 71.85007  ? 189 THR F CG2 1 
ATOM   938  N N   . SER A 1 155 ? 174.62800 315.17500 6.79300   1.000 75.70162  ? 190 SER F N   1 
ATOM   939  C CA  . SER A 1 155 ? 173.27100 315.11900 6.28000   1.000 83.28588  ? 190 SER F CA  1 
ATOM   940  C C   . SER A 1 155 ? 173.30600 315.06300 4.75900   1.000 83.38668  ? 190 SER F C   1 
ATOM   941  O O   . SER A 1 155 ? 174.23600 315.57700 4.13800   1.000 80.15409  ? 190 SER F O   1 
ATOM   942  C CB  . SER A 1 155 ? 172.45700 316.33000 6.77100   1.000 81.75942  ? 190 SER F CB  1 
ATOM   943  O OG  . SER A 1 155 ? 171.08900 315.99500 6.90900   1.000 87.83490  ? 190 SER F OG  1 
ATOM   944  N N   . LYS A 1 156 ? 172.30400 314.38500 4.17200   1.000 83.74901  ? 191 LYS F N   1 
ATOM   945  C CA  . LYS A 1 156 ? 172.01700 314.39500 2.73300   1.000 79.49412  ? 191 LYS F CA  1 
ATOM   946  C C   . LYS A 1 156 ? 170.75400 315.20800 2.53800   1.000 79.65961  ? 191 LYS F C   1 
ATOM   947  O O   . LYS A 1 156 ? 169.64900 314.69900 2.74300   1.000 84.61486  ? 191 LYS F O   1 
ATOM   948  C CB  . LYS A 1 156 ? 171.79100 312.99600 2.17400   1.000 89.61454  ? 191 LYS F CB  1 
ATOM   949  C CG  . LYS A 1 156 ? 171.47900 313.00200 0.66900   1.000 83.88475  ? 191 LYS F CG  1 
ATOM   950  C CD  . LYS A 1 156 ? 171.62600 311.64300 0.00600   1.000 89.64648  ? 191 LYS F CD  1 
ATOM   951  C CE  . LYS A 1 156 ? 173.03800 311.10900 0.05100   1.000 90.67678  ? 191 LYS F CE  1 
ATOM   952  N NZ  . LYS A 1 156 ? 173.11500 309.80100 -0.65800  1.000 91.47674  ? 191 LYS F NZ  1 
ATOM   953  N N   . VAL A 1 157 ? 170.89700 316.49000 2.22500   1.000 75.12042  ? 192 VAL F N   1 
ATOM   954  C CA  . VAL A 1 157 ? 169.68200 317.30100 2.19000   1.000 78.84285  ? 192 VAL F CA  1 
ATOM   955  C C   . VAL A 1 157 ? 168.99200 317.35300 0.82400   1.000 78.40862  ? 192 VAL F C   1 
ATOM   956  O O   . VAL A 1 157 ? 167.82200 317.76100 0.73800   1.000 75.62253  ? 192 VAL F O   1 
ATOM   957  C CB  . VAL A 1 157 ? 169.99400 318.71800 2.69700   1.000 75.33187  ? 192 VAL F CB  1 
ATOM   958  C CG1 . VAL A 1 157 ? 170.48600 318.61700 4.15300   1.000 76.38789  ? 192 VAL F CG1 1 
ATOM   959  C CG2 . VAL A 1 157 ? 170.96900 319.44500 1.74600   1.000 67.36290  ? 192 VAL F CG2 1 
ATOM   960  N N   . LEU A 1 158 ? 169.68700 316.97900 -0.24600  1.000 72.79780  ? 193 LEU F N   1 
ATOM   961  C CA  . LEU A 1 158 ? 169.13500 317.04800 -1.59100  1.000 72.81453  ? 193 LEU F CA  1 
ATOM   962  C C   . LEU A 1 158 ? 169.75400 315.94500 -2.43500  1.000 76.65037  ? 193 LEU F C   1 
ATOM   963  O O   . LEU A 1 158 ? 170.95100 315.65800 -2.30900  1.000 74.71847  ? 193 LEU F O   1 
ATOM   964  C CB  . LEU A 1 158 ? 169.38900 318.44000 -2.20500  1.000 73.22072  ? 193 LEU F CB  1 
ATOM   965  C CG  . LEU A 1 158 ? 168.76600 318.80700 -3.56000  1.000 70.28817  ? 193 LEU F CG  1 
ATOM   966  C CD1 . LEU A 1 158 ? 167.24900 318.86300 -3.43000  1.000 73.24137  ? 193 LEU F CD1 1 
ATOM   967  C CD2 . LEU A 1 158 ? 169.32700 320.10400 -4.13100  1.000 64.85080  ? 193 LEU F CD2 1 
ATOM   968  N N   . ASP A 1 159 ? 168.93800 315.29900 -3.26500  1.000 78.30540  ? 194 ASP F N   1 
ATOM   969  C CA  . ASP A 1 159 ? 169.44600 314.19800 -4.08200  1.000 77.83984  ? 194 ASP F CA  1 
ATOM   970  C C   . ASP A 1 159 ? 169.17300 314.50100 -5.54900  1.000 76.17314  ? 194 ASP F C   1 
ATOM   971  O O   . ASP A 1 159 ? 168.10200 314.19400 -6.07600  1.000 80.38278  ? 194 ASP F O   1 
ATOM   972  C CB  . ASP A 1 159 ? 168.83100 312.85000 -3.68200  1.000 83.45689  ? 194 ASP F CB  1 
ATOM   973  C CG  . ASP A 1 159 ? 169.60400 311.65300 -4.26700  1.000 87.92560  ? 194 ASP F CG  1 
ATOM   974  O OD1 . ASP A 1 159 ? 170.70000 311.85300 -4.85500  1.000 84.33773  ? 194 ASP F OD1 1 
ATOM   975  O OD2 . ASP A 1 159 ? 169.11600 310.51000 -4.15300  1.000 93.18407  ? 194 ASP F OD2 1 
ATOM   976  N N   . LEU A 1 160 ? 170.13700 315.17400 -6.18100  1.000 73.57619  ? 195 LEU F N   1 
ATOM   977  C CA  . LEU A 1 160 ? 170.05200 315.46000 -7.60100  1.000 75.40336  ? 195 LEU F CA  1 
ATOM   978  C C   . LEU A 1 160 ? 170.64200 314.36500 -8.48100  1.000 76.51359  ? 195 LEU F C   1 
ATOM   979  O O   . LEU A 1 160 ? 170.24100 314.25300 -9.64600  1.000 75.64563  ? 195 LEU F O   1 
ATOM   980  C CB  . LEU A 1 160 ? 170.73900 316.78900 -7.92700  1.000 62.27295  ? 195 LEU F CB  1 
ATOM   981  C CG  . LEU A 1 160 ? 169.99000 318.02900 -7.44500  1.000 65.74398  ? 195 LEU F CG  1 
ATOM   982  C CD1 . LEU A 1 160 ? 170.72600 319.29900 -7.83900  1.000 56.91807  ? 195 LEU F CD1 1 
ATOM   983  C CD2 . LEU A 1 160 ? 168.60000 318.03700 -8.05400  1.000 67.70529  ? 195 LEU F CD2 1 
ATOM   984  N N   . LYS A 1 161 ? 171.61500 313.58000 -7.99400  1.000 73.35108  ? 196 LYS F N   1 
ATOM   985  C CA  . LYS A 1 161 ? 172.12600 312.50500 -8.84600  1.000 81.39979  ? 196 LYS F CA  1 
ATOM   986  C C   . LYS A 1 161 ? 171.05100 311.45600 -9.11000  1.000 80.84383  ? 196 LYS F C   1 
ATOM   987  O O   . LYS A 1 161 ? 170.91400 310.97300 -10.23800 1.000 79.99663  ? 196 LYS F O   1 
ATOM   988  C CB  . LYS A 1 161 ? 173.38600 311.85600 -8.25700  1.000 79.24768  ? 196 LYS F CB  1 
ATOM   989  C CG  . LYS A 1 161 ? 173.94300 310.79000 -9.20200  1.000 82.22742  ? 196 LYS F CG  1 
ATOM   990  C CD  . LYS A 1 161 ? 175.28200 310.15900 -8.82500  1.000 78.46615  ? 196 LYS F CD  1 
ATOM   991  C CE  . LYS A 1 161 ? 175.21600 309.27200 -7.59900  1.000 86.64637  ? 196 LYS F CE  1 
ATOM   992  N NZ  . LYS A 1 161 ? 176.58700 308.76400 -7.25500  1.000 88.97047  ? 196 LYS F NZ  1 
ATOM   993  N N   . ASN A 1 162 ? 170.23700 311.14100 -8.09700  1.000 82.11440  ? 197 ASN F N   1 
ATOM   994  C CA  . ASN A 1 162 ? 169.17100 310.16100 -8.27800  1.000 83.69877  ? 197 ASN F CA  1 
ATOM   995  C C   . ASN A 1 162 ? 168.13200 310.66200 -9.26700  1.000 82.39365  ? 197 ASN F C   1 
ATOM   996  O O   . ASN A 1 162 ? 167.78200 309.95200 -10.22200 1.000 86.70611  ? 197 ASN F O   1 
ATOM   997  C CB  . ASN A 1 162 ? 168.51100 309.86200 -6.93000  1.000 85.19855  ? 197 ASN F CB  1 
ATOM   998  C CG  . ASN A 1 162 ? 167.32500 308.91200 -7.04400  1.000 91.13369  ? 197 ASN F CG  1 
ATOM   999  O OD1 . ASN A 1 162 ? 166.33500 309.04200 -6.31300  1.000 92.32435  ? 197 ASN F OD1 1 
ATOM   1000 N ND2 . ASN A 1 162 ? 167.41800 307.95000 -7.95400  1.000 91.78019  ? 197 ASN F ND2 1 
ATOM   1001 N N   . TYR A 1 163 ? 167.81700 311.95200 -9.19900  1.000 79.90825  ? 198 TYR F N   1 
ATOM   1002 C CA  . TYR A 1 163 ? 166.77700 312.48000 -10.06800 1.000 79.77253  ? 198 TYR F CA  1 
ATOM   1003 C C   . TYR A 1 163 ? 167.27500 312.65200 -11.48800 1.000 82.94900  ? 198 TYR F C   1 
ATOM   1004 O O   . TYR A 1 163 ? 166.56900 312.30500 -12.44700 1.000 84.62113  ? 198 TYR F O   1 
ATOM   1005 C CB  . TYR A 1 163 ? 166.30200 313.82200 -9.52000  1.000 70.43601  ? 198 TYR F CB  1 
ATOM   1006 C CG  . TYR A 1 163 ? 165.07000 314.35800 -10.17500 1.000 73.07876  ? 198 TYR F CG  1 
ATOM   1007 C CD1 . TYR A 1 163 ? 163.80900 313.98600 -9.74400  1.000 74.67123  ? 198 TYR F CD1 1 
ATOM   1008 C CD2 . TYR A 1 163 ? 165.16700 315.20800 -11.26500 1.000 73.17992  ? 198 TYR F CD2 1 
ATOM   1009 C CE1 . TYR A 1 163 ? 162.67800 314.47500 -10.35800 1.000 73.52949  ? 198 TYR F CE1 1 
ATOM   1010 C CE2 . TYR A 1 163 ? 164.04100 315.69800 -11.89800 1.000 71.61841  ? 198 TYR F CE2 1 
ATOM   1011 C CZ  . TYR A 1 163 ? 162.79800 315.32700 -11.43900 1.000 73.40729  ? 198 TYR F CZ  1 
ATOM   1012 O OH  . TYR A 1 163 ? 161.67000 315.81800 -12.05700 1.000 74.03002  ? 198 TYR F OH  1 
ATOM   1013 N N   . ILE A 1 164 ? 168.49700 313.13700 -11.64700 1.000 79.84332  ? 199 ILE F N   1 
ATOM   1014 C CA  . ILE A 1 164 ? 168.98200 313.35500 -12.99700 1.000 80.64056  ? 199 ILE F CA  1 
ATOM   1015 C C   . ILE A 1 164 ? 169.29200 312.00500 -13.67700 1.000 82.30403  ? 199 ILE F C   1 
ATOM   1016 O O   . ILE A 1 164 ? 168.95100 311.78500 -14.84500 1.000 82.90043  ? 199 ILE F O   1 
ATOM   1017 C CB  . ILE A 1 164 ? 170.15600 314.34300 -12.99100 1.000 74.80583  ? 199 ILE F CB  1 
ATOM   1018 C CG1 . ILE A 1 164 ? 169.63400 315.70400 -12.46100 1.000 72.17687  ? 199 ILE F CG1 1 
ATOM   1019 C CG2 . ILE A 1 164 ? 170.77500 314.43500 -14.38400 1.000 76.57998  ? 199 ILE F CG2 1 
ATOM   1020 C CD1 . ILE A 1 164 ? 170.62000 316.79000 -12.56700 1.000 71.17940  ? 199 ILE F CD1 1 
ATOM   1021 N N   . ASP A 1 165 ? 169.93200 311.06300 -12.96300 1.000 83.79405  ? 200 ASP F N   1 
ATOM   1022 C CA  . ASP A 1 165 ? 170.33000 309.81900 -13.62700 1.000 86.73349  ? 200 ASP F CA  1 
ATOM   1023 C C   . ASP A 1 165 ? 169.13900 308.90000 -13.89900 1.000 88.65198  ? 200 ASP F C   1 
ATOM   1024 O O   . ASP A 1 165 ? 169.19000 308.08800 -14.83400 1.000 89.54340  ? 200 ASP F O   1 
ATOM   1025 C CB  . ASP A 1 165 ? 171.39000 309.08300 -12.79500 1.000 82.09841  ? 200 ASP F CB  1 
ATOM   1026 C CG  . ASP A 1 165 ? 172.71400 309.83300 -12.73100 1.000 85.98861  ? 200 ASP F CG  1 
ATOM   1027 O OD1 . ASP A 1 165 ? 172.72300 311.06100 -12.96200 1.000 87.62937  ? 200 ASP F OD1 1 
ATOM   1028 O OD2 . ASP A 1 165 ? 173.74300 309.20400 -12.40500 1.000 83.98400  ? 200 ASP F OD2 1 
ATOM   1029 N N   . LYS A 1 166 ? 168.06300 309.00500 -13.12300 1.000 86.83118  ? 201 LYS F N   1 
ATOM   1030 C CA  . LYS A 1 166 ? 166.90900 308.14600 -13.35000 1.000 86.33997  ? 201 LYS F CA  1 
ATOM   1031 C C   . LYS A 1 166 ? 165.80700 308.78500 -14.19800 1.000 88.76138  ? 201 LYS F C   1 
ATOM   1032 O O   . LYS A 1 166 ? 165.21900 308.10600 -15.04500 1.000 93.38944  ? 201 LYS F O   1 
ATOM   1033 C CB  . LYS A 1 166 ? 166.33400 307.62700 -12.03300 1.000 86.19387  ? 201 LYS F CB  1 
ATOM   1034 C CG  . LYS A 1 166 ? 167.19800 306.54500 -11.41100 1.000 89.76265  ? 201 LYS F CG  1 
ATOM   1035 C CD  . LYS A 1 166 ? 166.53800 305.97100 -10.17000 1.000 91.06213  ? 201 LYS F CD  1 
ATOM   1036 C CE  . LYS A 1 166 ? 167.33500 304.79700 -9.61300  1.000 93.17783  ? 201 LYS F CE  1 
ATOM   1037 N NZ  . LYS A 1 166 ? 168.33100 305.20600 -8.59000  1.000 98.03712  ? 201 LYS F NZ  1 
ATOM   1038 N N   . GLN A 1 167 ? 165.53000 310.08600 -14.03600 1.000 86.92761  ? 202 GLN F N   1 
ATOM   1039 C CA  . GLN A 1 167 ? 164.37700 310.70800 -14.67800 1.000 82.22139  ? 202 GLN F CA  1 
ATOM   1040 C C   . GLN A 1 167 ? 164.75300 311.54800 -15.89700 1.000 83.31956  ? 202 GLN F C   1 
ATOM   1041 O O   . GLN A 1 167 ? 163.89200 311.81100 -16.73900 1.000 84.79713  ? 202 GLN F O   1 
ATOM   1042 C CB  . GLN A 1 167 ? 163.68800 311.65900 -13.68800 1.000 82.20383  ? 202 GLN F CB  1 
ATOM   1043 C CG  . GLN A 1 167 ? 162.73100 311.05600 -12.66100 1.000 83.93023  ? 202 GLN F CG  1 
ATOM   1044 C CD  . GLN A 1 167 ? 163.50300 310.16500 -11.68000 1.000 91.18621  ? 202 GLN F CD  1 
ATOM   1045 O OE1 . GLN A 1 167 ? 164.54700 309.61800 -12.02400 1.000 89.73403  ? 202 GLN F OE1 1 
ATOM   1046 N NE2 . GLN A 1 167 ? 163.04800 310.11500 -10.42500 1.000 90.31563  ? 202 GLN F NE2 1 
ATOM   1047 N N   . LEU A 1 168 ? 165.99600 312.00300 -15.99100 1.000 84.57265  ? 203 LEU F N   1 
ATOM   1048 C CA  . LEU A 1 168 ? 166.46800 312.91000 -17.03500 1.000 86.92065  ? 203 LEU F CA  1 
ATOM   1049 C C   . LEU A 1 168 ? 167.38500 312.25700 -18.06400 1.000 92.45848  ? 203 LEU F C   1 
ATOM   1050 O O   . LEU A 1 168 ? 167.28200 312.57200 -19.24800 1.000 97.59972  ? 203 LEU F O   1 
ATOM   1051 C CB  . LEU A 1 168 ? 167.15700 314.12000 -16.40500 1.000 82.40408  ? 203 LEU F CB  1 
ATOM   1052 C CG  . LEU A 1 168 ? 166.20300 314.92600 -15.51800 1.000 77.78476  ? 203 LEU F CG  1 
ATOM   1053 C CD1 . LEU A 1 168 ? 166.86400 316.22200 -15.09500 1.000 73.39880  ? 203 LEU F CD1 1 
ATOM   1054 C CD2 . LEU A 1 168 ? 164.87400 315.19500 -16.19200 1.000 74.19000  ? 203 LEU F CD2 1 
ATOM   1055 N N   . LEU A 1 169 ? 168.32500 311.40800 -17.64900 1.000 91.55891  ? 204 LEU F N   1 
ATOM   1056 C CA  . LEU A 1 169 ? 169.24800 310.79300 -18.60500 1.000 100.26258 ? 204 LEU F CA  1 
ATOM   1057 C C   . LEU A 1 169 ? 168.53300 309.91400 -19.63000 1.000 105.67124 ? 204 LEU F C   1 
ATOM   1058 O O   . LEU A 1 169 ? 168.91500 309.96500 -20.81300 1.000 107.14417 ? 204 LEU F O   1 
ATOM   1059 C CB  . LEU A 1 169 ? 170.35000 310.00700 -17.88200 1.000 95.69789  ? 204 LEU F CB  1 
ATOM   1060 C CG  . LEU A 1 169 ? 171.38800 310.83400 -17.11400 1.000 97.64889  ? 204 LEU F CG  1 
ATOM   1061 C CD1 . LEU A 1 169 ? 172.51700 309.94400 -16.58300 1.000 94.23490  ? 204 LEU F CD1 1 
ATOM   1062 C CD2 . LEU A 1 169 ? 171.94000 312.00500 -17.93400 1.000 99.77203  ? 204 LEU F CD2 1 
ATOM   1063 N N   . PRO A 1 170 ? 167.53500 309.09700 -19.27700 1.000 104.16340 ? 205 PRO F N   1 
ATOM   1064 C CA  . PRO A 1 170 ? 166.79400 308.37000 -20.32400 1.000 104.77823 ? 205 PRO F CA  1 
ATOM   1065 C C   . PRO A 1 170 ? 166.12800 309.31800 -21.30800 1.000 106.33659 ? 205 PRO F C   1 
ATOM   1066 O O   . PRO A 1 170 ? 165.70800 308.88500 -22.39100 1.000 111.09424 ? 205 PRO F O   1 
ATOM   1067 C CB  . PRO A 1 170 ? 165.75800 307.55900 -19.53000 1.000 100.96441 ? 205 PRO F CB  1 
ATOM   1068 C CG  . PRO A 1 170 ? 166.34500 307.42800 -18.17300 1.000 97.74246  ? 205 PRO F CG  1 
ATOM   1069 C CD  . PRO A 1 170 ? 167.07000 308.72500 -17.92900 1.000 99.70869  ? 205 PRO F CD  1 
ATOM   1070 N N   . ILE A 1 171 ? 166.01700 310.59900 -20.94900 1.000 105.09203 ? 206 ILE F N   1 
ATOM   1071 C CA  . ILE A 1 171 ? 165.42500 311.61500 -21.81200 1.000 106.38170 ? 206 ILE F CA  1 
ATOM   1072 C C   . ILE A 1 171 ? 166.42300 312.27700 -22.76600 1.000 109.55812 ? 206 ILE F C   1 
ATOM   1073 O O   . ILE A 1 171 ? 165.99800 312.87600 -23.76400 1.000 114.81450 ? 206 ILE F O   1 
ATOM   1074 C CB  . ILE A 1 171 ? 164.77700 312.72000 -20.95600 1.000 101.84360 ? 206 ILE F CB  1 
ATOM   1075 C CG1 . ILE A 1 171 ? 163.63100 312.15700 -20.10400 1.000 101.70189 ? 206 ILE F CG1 1 
ATOM   1076 C CG2 . ILE A 1 171 ? 164.34500 313.90200 -21.82100 1.000 101.25102 ? 206 ILE F CG2 1 
ATOM   1077 C CD1 . ILE A 1 171 ? 162.48900 311.55100 -20.89100 1.000 102.94512 ? 206 ILE F CD1 1 
ATOM   1078 N N   . VAL A 1 172 ? 167.73200 312.19000 -22.50500 1.000 111.69602 ? 207 VAL F N   1 
ATOM   1079 C CA  . VAL A 1 172 ? 168.71200 312.73400 -23.44900 1.000 116.54270 ? 207 VAL F CA  1 
ATOM   1080 C C   . VAL A 1 172 ? 169.79400 311.70800 -23.79300 1.000 121.00138 ? 207 VAL F C   1 
ATOM   1081 O O   . VAL A 1 172 ? 170.86600 312.07500 -24.29100 1.000 120.41814 ? 207 VAL F O   1 
ATOM   1082 C CB  . VAL A 1 172 ? 169.34800 314.04200 -22.92800 1.000 115.08968 ? 207 VAL F CB  1 
ATOM   1083 C CG1 . VAL A 1 172 ? 168.32500 315.17900 -22.91900 1.000 109.41940 ? 207 VAL F CG1 1 
ATOM   1084 C CG2 . VAL A 1 172 ? 169.97000 313.84600 -21.54400 1.000 113.36754 ? 207 VAL F CG2 1 
ATOM   1085 N N   . ASN A 1 173 ? 169.52100 310.41500 -23.55200 1.000 122.32110 ? 208 ASN F N   1 
ATOM   1086 C CA  . ASN A 1 173 ? 170.44000 309.35600 -23.97300 1.000 124.51644 ? 208 ASN F CA  1 
ATOM   1087 C C   . ASN A 1 173 ? 169.79700 308.36900 -24.93800 1.000 126.29129 ? 208 ASN F C   1 
ATOM   1088 O O   . ASN A 1 173 ? 169.71000 307.17000 -24.64500 1.000 123.68888 ? 208 ASN F O   1 
ATOM   1089 C CB  . ASN A 1 173 ? 170.95700 308.57300 -22.76200 1.000 123.16481 ? 208 ASN F CB  1 
ATOM   1090 C CG  . ASN A 1 173 ? 171.97400 309.34600 -21.95300 1.000 125.08022 ? 208 ASN F CG  1 
ATOM   1091 O OD1 . ASN A 1 173 ? 171.97900 310.57800 -21.95300 1.000 124.87587 ? 208 ASN F OD1 1 
ATOM   1092 N ND2 . ASN A 1 173 ? 172.84100 308.62400 -21.24600 1.000 123.63993 ? 208 ASN F ND2 1 
ATOM   1093 N N   . LYS A 1 174 ? 169.33800 308.87000 -26.08200 1.000 130.91674 ? 209 LYS F N   1 
ATOM   1094 C CA  . LYS A 1 174 ? 168.73600 308.05900 -27.13300 1.000 132.97153 ? 209 LYS F CA  1 
ATOM   1095 C C   . LYS A 1 174 ? 169.24700 308.60600 -28.46800 1.000 137.98975 ? 209 LYS F C   1 
ATOM   1096 O O   . LYS A 1 174 ? 170.10400 309.49900 -28.50800 1.000 134.02480 ? 209 LYS F O   1 
ATOM   1097 C CB  . LYS A 1 174 ? 167.20100 308.09500 -27.02500 1.000 127.40276 ? 209 LYS F CB  1 
ATOM   1098 C CG  . LYS A 1 174 ? 166.63200 307.48500 -25.74500 1.000 121.81803 ? 209 LYS F CG  1 
ATOM   1099 C CD  . LYS A 1 174 ? 167.01000 306.02300 -25.57900 1.000 116.14637 ? 209 LYS F CD  1 
ATOM   1100 C CE  . LYS A 1 174 ? 166.51400 305.48900 -24.24600 1.000 112.01238 ? 209 LYS F CE  1 
ATOM   1101 N NZ  . LYS A 1 174 ? 166.75700 304.02900 -24.11400 1.000 108.92743 ? 209 LYS F NZ  1 
ATOM   1102 N N   . GLN A 1 175 ? 168.71600 308.07100 -29.57600 1.000 140.71947 ? 210 GLN F N   1 
ATOM   1103 C CA  . GLN A 1 175 ? 169.05200 308.61400 -30.89300 1.000 140.19392 ? 210 GLN F CA  1 
ATOM   1104 C C   . GLN A 1 175 ? 168.40900 309.98800 -31.01900 1.000 138.49701 ? 210 GLN F C   1 
ATOM   1105 O O   . GLN A 1 175 ? 169.07200 310.98900 -31.32900 1.000 133.23353 ? 210 GLN F O   1 
ATOM   1106 C CB  . GLN A 1 175 ? 168.56600 307.67700 -32.00900 1.000 139.35023 ? 210 GLN F CB  1 
ATOM   1107 C CG  . GLN A 1 175 ? 169.42400 307.64600 -33.29000 1.000 138.88440 ? 210 GLN F CG  1 
ATOM   1108 C CD  . GLN A 1 175 ? 170.71900 306.86500 -33.15400 1.000 137.08146 ? 210 GLN F CD  1 
ATOM   1109 O OE1 . GLN A 1 175 ? 170.72700 305.72100 -32.70100 1.000 136.00327 ? 210 GLN F OE1 1 
ATOM   1110 N NE2 . GLN A 1 175 ? 171.82200 307.47800 -33.56900 1.000 134.94862 ? 210 GLN F NE2 1 
ATOM   1111 N N   . SER A 1 176 ? 167.10800 310.03600 -30.75900 1.000 138.76403 ? 211 SER F N   1 
ATOM   1112 C CA  . SER A 1 176 ? 166.32700 311.25400 -30.65700 1.000 135.48470 ? 211 SER F CA  1 
ATOM   1113 C C   . SER A 1 176 ? 165.86000 311.32300 -29.20500 1.000 132.42856 ? 211 SER F C   1 
ATOM   1114 O O   . SER A 1 176 ? 165.56600 310.29300 -28.58200 1.000 129.44285 ? 211 SER F O   1 
ATOM   1115 C CB  . SER A 1 176 ? 165.14100 311.26000 -31.63200 1.000 130.34313 ? 211 SER F CB  1 
ATOM   1116 O OG  . SER A 1 176 ? 164.61500 312.56800 -31.80300 1.000 126.45286 ? 211 SER F OG  1 
ATOM   1117 N N   . CYS A 1 177 ? 165.80700 312.52900 -28.66100 1.000 130.78832 ? 212 CYS F N   1 
ATOM   1118 C CA  . CYS A 1 177 ? 165.47800 312.67600 -27.25300 1.000 126.74229 ? 212 CYS F CA  1 
ATOM   1119 C C   . CYS A 1 177 ? 164.05300 312.18200 -27.03100 1.000 120.33180 ? 212 CYS F C   1 
ATOM   1120 O O   . CYS A 1 177 ? 163.16000 312.45000 -27.83800 1.000 121.39790 ? 212 CYS F O   1 
ATOM   1121 C CB  . CYS A 1 177 ? 165.61000 314.14800 -26.84000 1.000 121.08576 ? 212 CYS F CB  1 
ATOM   1122 S SG  . CYS A 1 177 ? 167.05200 315.08000 -27.54100 1.000 137.21741 ? 212 CYS F SG  1 
ATOM   1123 N N   . SER A 1 178 ? 163.83400 311.43200 -25.95200 1.000 113.20816 ? 213 SER F N   1 
ATOM   1124 C CA  . SER A 1 178 ? 162.44300 311.15100 -25.63900 1.000 109.60276 ? 213 SER F CA  1 
ATOM   1125 C C   . SER A 1 178 ? 161.77800 312.38800 -25.01700 1.000 106.32315 ? 213 SER F C   1 
ATOM   1126 O O   . SER A 1 178 ? 162.43400 313.26600 -24.45100 1.000 107.23349 ? 213 SER F O   1 
ATOM   1127 C CB  . SER A 1 178 ? 162.34100 309.94200 -24.71100 1.000 103.60345 ? 213 SER F CB  1 
ATOM   1128 O OG  . SER A 1 178 ? 162.40600 310.34100 -23.36300 1.000 102.24265 ? 213 SER F OG  1 
ATOM   1129 N N   . ILE A 1 179 ? 160.45200 312.42700 -25.11900 1.000 104.24766 ? 214 ILE F N   1 
ATOM   1130 C CA  . ILE A 1 179 ? 159.66300 313.59500 -24.71000 1.000 101.57112 ? 214 ILE F CA  1 
ATOM   1131 C C   . ILE A 1 179 ? 159.31200 313.45100 -23.22500 1.000 99.87371  ? 214 ILE F C   1 
ATOM   1132 O O   . ILE A 1 179 ? 158.55200 312.54400 -22.86200 1.000 101.29634 ? 214 ILE F O   1 
ATOM   1133 C CB  . ILE A 1 179 ? 158.40500 313.76600 -25.57100 1.000 103.88319 ? 214 ILE F CB  1 
ATOM   1134 C CG1 . ILE A 1 179 ? 158.79300 313.88300 -27.05100 1.000 102.62208 ? 214 ILE F CG1 1 
ATOM   1135 C CG2 . ILE A 1 179 ? 157.66000 315.03700 -25.14900 1.000 95.96291  ? 214 ILE F CG2 1 
ATOM   1136 C CD1 . ILE A 1 179 ? 159.81000 314.96700 -27.34800 1.000 99.71788  ? 214 ILE F CD1 1 
ATOM   1137 N N   . PRO A 1 180 ? 159.82200 314.32700 -22.36500 1.000 98.51858  ? 215 PRO F N   1 
ATOM   1138 C CA  . PRO A 1 180 ? 159.43600 314.30900 -20.95100 1.000 95.25541  ? 215 PRO F CA  1 
ATOM   1139 C C   . PRO A 1 180 ? 158.14300 315.07600 -20.71600 1.000 89.84938  ? 215 PRO F C   1 
ATOM   1140 O O   . PRO A 1 180 ? 157.77600 315.97300 -21.48000 1.000 89.80644  ? 215 PRO F O   1 
ATOM   1141 C CB  . PRO A 1 180 ? 160.61600 315.01000 -20.26700 1.000 94.27952  ? 215 PRO F CB  1 
ATOM   1142 C CG  . PRO A 1 180 ? 161.06400 316.01500 -21.29600 1.000 92.17188  ? 215 PRO F CG  1 
ATOM   1143 C CD  . PRO A 1 180 ? 160.80800 315.38300 -22.65500 1.000 95.07905  ? 215 PRO F CD  1 
ATOM   1144 N N   . ASN A 1 181 ? 157.41000 314.65800 -19.68400 1.000 85.40719  ? 216 ASN F N   1 
ATOM   1145 C CA  . ASN A 1 181 ? 156.15900 315.33000 -19.34600 1.000 87.74658  ? 216 ASN F CA  1 
ATOM   1146 C C   . ASN A 1 181 ? 156.44700 316.67700 -18.67400 1.000 84.78984  ? 216 ASN F C   1 
ATOM   1147 O O   . ASN A 1 181 ? 157.52400 316.90400 -18.11600 1.000 83.37187  ? 216 ASN F O   1 
ATOM   1148 C CB  . ASN A 1 181 ? 155.33000 314.47400 -18.38700 1.000 85.18648  ? 216 ASN F CB  1 
ATOM   1149 C CG  . ASN A 1 181 ? 154.81800 313.20900 -19.02700 1.000 94.44981  ? 216 ASN F CG  1 
ATOM   1150 O OD1 . ASN A 1 181 ? 154.07200 313.25200 -20.00600 1.000 93.97165  ? 216 ASN F OD1 1 
ATOM   1151 N ND2 . ASN A 1 181 ? 155.22900 312.06500 -18.48800 1.000 96.11580  ? 216 ASN F ND2 1 
ATOM   1152 N N   . ILE A 1 182 ? 155.46000 317.58000 -18.74000 1.000 84.25693  ? 217 ILE F N   1 
ATOM   1153 C CA  . ILE A 1 182 ? 155.61200 318.92100 -18.16800 1.000 83.55128  ? 217 ILE F CA  1 
ATOM   1154 C C   . ILE A 1 182 ? 155.76200 318.88100 -16.65300 1.000 81.01233  ? 217 ILE F C   1 
ATOM   1155 O O   . ILE A 1 182 ? 156.38100 319.78200 -16.05200 1.000 80.58144  ? 217 ILE F O   1 
ATOM   1156 C CB  . ILE A 1 182 ? 154.40400 319.79300 -18.55900 1.000 82.46245  ? 217 ILE F CB  1 
ATOM   1157 C CG1 . ILE A 1 182 ? 154.74100 321.28100 -18.44800 1.000 78.54084  ? 217 ILE F CG1 1 
ATOM   1158 C CG2 . ILE A 1 182 ? 153.21100 319.46000 -17.68300 1.000 82.08760  ? 217 ILE F CG2 1 
ATOM   1159 C CD1 . ILE A 1 182 ? 155.87000 321.70500 -19.37600 1.000 75.31382  ? 217 ILE F CD1 1 
ATOM   1160 N N   . GLU A 1 183 ? 155.27300 317.81400 -16.03000 1.000 78.42477  ? 218 GLU F N   1 
ATOM   1161 C CA  . GLU A 1 183 ? 155.48300 317.62800 -14.60400 1.000 78.92221  ? 218 GLU F CA  1 
ATOM   1162 C C   . GLU A 1 183 ? 156.96200 317.44700 -14.31600 1.000 75.54226  ? 218 GLU F C   1 
ATOM   1163 O O   . GLU A 1 183 ? 157.46500 317.93800 -13.30600 1.000 74.30676  ? 218 GLU F O   1 
ATOM   1164 C CB  . GLU A 1 183 ? 154.66500 316.44200 -14.10200 1.000 79.16914  ? 218 GLU F CB  1 
ATOM   1165 C CG  . GLU A 1 183 ? 153.18200 316.74100 -14.17400 1.000 86.75595  ? 218 GLU F CG  1 
ATOM   1166 C CD  . GLU A 1 183 ? 152.62500 316.46900 -15.56900 1.000 87.77866  ? 218 GLU F CD  1 
ATOM   1167 O OE1 . GLU A 1 183 ? 153.22400 315.63500 -16.29300 1.000 85.76071  ? 218 GLU F OE1 1 
ATOM   1168 O OE2 . GLU A 1 183 ? 151.63900 317.13700 -15.96400 1.000 86.41012  ? 218 GLU F OE2 1 
ATOM   1169 N N   . THR A 1 184 ? 157.68000 316.77500 -15.21400 1.000 76.92188  ? 219 THR F N   1 
ATOM   1170 C CA  . THR A 1 184 ? 159.11300 316.59400 -15.02600 1.000 75.41361  ? 219 THR F CA  1 
ATOM   1171 C C   . THR A 1 184 ? 159.84400 317.92300 -15.12500 1.000 73.89361  ? 219 THR F C   1 
ATOM   1172 O O   . THR A 1 184 ? 160.78200 318.17200 -14.36800 1.000 71.82808  ? 219 THR F O   1 
ATOM   1173 C CB  . THR A 1 184 ? 159.64300 315.60200 -16.05500 1.000 74.87302  ? 219 THR F CB  1 
ATOM   1174 O OG1 . THR A 1 184 ? 159.02400 314.33200 -15.83600 1.000 78.73560  ? 219 THR F OG1 1 
ATOM   1175 C CG2 . THR A 1 184 ? 161.15000 315.45100 -15.93900 1.000 77.75422  ? 219 THR F CG2 1 
ATOM   1176 N N   . VAL A 1 185 ? 159.44500 318.78100 -16.05900 1.000 72.20613  ? 220 VAL F N   1 
ATOM   1177 C CA  . VAL A 1 185 ? 160.07700 320.09100 -16.17500 1.000 71.63716  ? 220 VAL F CA  1 
ATOM   1178 C C   . VAL A 1 185 ? 159.87700 320.90700 -14.90200 1.000 73.25622  ? 220 VAL F C   1 
ATOM   1179 O O   . VAL A 1 185 ? 160.83700 321.50200 -14.36800 1.000 71.05452  ? 220 VAL F O   1 
ATOM   1180 C CB  . VAL A 1 185 ? 159.54300 320.84200 -17.40400 1.000 73.84697  ? 220 VAL F CB  1 
ATOM   1181 C CG1 . VAL A 1 185 ? 160.12900 322.25400 -17.46100 1.000 70.04423  ? 220 VAL F CG1 1 
ATOM   1182 C CG2 . VAL A 1 185 ? 159.89500 320.07600 -18.66300 1.000 74.61908  ? 220 VAL F CG2 1 
ATOM   1183 N N   . ILE A 1 186 ? 158.66400 320.85500 -14.32600 1.000 68.44254  ? 221 ILE F N   1 
ATOM   1184 C CA  . ILE A 1 186 ? 158.44300 321.66700 -13.13400 1.000 68.33299  ? 221 ILE F CA  1 
ATOM   1185 C C   . ILE A 1 186 ? 159.15900 321.06400 -11.93500 1.000 70.36024  ? 221 ILE F C   1 
ATOM   1186 O O   . ILE A 1 186 ? 159.81000 321.78400 -11.16100 1.000 70.40741  ? 221 ILE F O   1 
ATOM   1187 C CB  . ILE A 1 186 ? 156.93500 321.83700 -12.86900 1.000 67.23816  ? 221 ILE F CB  1 
ATOM   1188 C CG1 . ILE A 1 186 ? 156.33400 322.65700 -14.00700 1.000 65.90759  ? 221 ILE F CG1 1 
ATOM   1189 C CG2 . ILE A 1 186 ? 156.65800 322.42000 -11.48800 1.000 62.92171  ? 221 ILE F CG2 1 
ATOM   1190 C CD1 . ILE A 1 186 ? 154.85900 322.94100 -13.80700 1.000 72.54646  ? 221 ILE F CD1 1 
ATOM   1191 N N   . GLU A 1 187 ? 159.10200 319.74300 -11.77600 1.000 67.48205  ? 222 GLU F N   1 
ATOM   1192 C CA  . GLU A 1 187 ? 159.79100 319.14200 -10.64200 1.000 69.70574  ? 222 GLU F CA  1 
ATOM   1193 C C   . GLU A 1 187 ? 161.29700 319.33400 -10.73400 1.000 67.53182  ? 222 GLU F C   1 
ATOM   1194 O O   . GLU A 1 187 ? 161.97200 319.48300 -9.70500  1.000 65.83055  ? 222 GLU F O   1 
ATOM   1195 C CB  . GLU A 1 187 ? 159.46700 317.65800 -10.48600 1.000 70.39692  ? 222 GLU F CB  1 
ATOM   1196 C CG  . GLU A 1 187 ? 159.84100 317.20300 -9.06700  1.000 78.34121  ? 222 GLU F CG  1 
ATOM   1197 C CD  . GLU A 1 187 ? 159.31300 315.82700 -8.67300  1.000 90.17899  ? 222 GLU F CD  1 
ATOM   1198 O OE1 . GLU A 1 187 ? 158.95100 315.03200 -9.57500  1.000 89.78656  ? 222 GLU F OE1 1 
ATOM   1199 O OE2 . GLU A 1 187 ? 159.23800 315.56900 -7.43900  1.000 93.36892  ? 222 GLU F OE2 1 
ATOM   1200 N N   . PHE A 1 188 ? 161.84500 319.39400 -11.94500 1.000 65.36689  ? 223 PHE F N   1 
ATOM   1201 C CA  . PHE A 1 188 ? 163.28000 319.59200 -12.01000 1.000 67.28067  ? 223 PHE F CA  1 
ATOM   1202 C C   . PHE A 1 188 ? 163.64900 321.02400 -11.72300 1.000 66.51011  ? 223 PHE F C   1 
ATOM   1203 O O   . PHE A 1 188 ? 164.65700 321.25000 -11.06000 1.000 65.51783  ? 223 PHE F O   1 
ATOM   1204 C CB  . PHE A 1 188 ? 163.80600 319.22000 -13.39100 1.000 64.39854  ? 223 PHE F CB  1 
ATOM   1205 C CG  . PHE A 1 188 ? 165.30100 319.30900 -13.53200 1.000 61.62765  ? 223 PHE F CG  1 
ATOM   1206 C CD1 . PHE A 1 188 ? 166.14000 318.73100 -12.59400 1.000 61.80023  ? 223 PHE F CD1 1 
ATOM   1207 C CD2 . PHE A 1 188 ? 165.86500 319.91500 -14.65200 1.000 62.17922  ? 223 PHE F CD2 1 
ATOM   1208 C CE1 . PHE A 1 188 ? 167.51700 318.78600 -12.74400 1.000 60.80871  ? 223 PHE F CE1 1 
ATOM   1209 C CE2 . PHE A 1 188 ? 167.23600 319.97700 -14.81300 1.000 61.35906  ? 223 PHE F CE2 1 
ATOM   1210 C CZ  . PHE A 1 188 ? 168.06600 319.41300 -13.86000 1.000 61.38389  ? 223 PHE F CZ  1 
ATOM   1211 N N   . GLN A 1 189 ? 162.81600 321.99000 -12.10100 1.000 61.31815  ? 224 GLN F N   1 
ATOM   1212 C CA  . GLN A 1 189 ? 163.15000 323.34400 -11.70300 1.000 66.44264  ? 224 GLN F CA  1 
ATOM   1213 C C   . GLN A 1 189 ? 163.01700 323.53000 -10.19500 1.000 67.44692  ? 224 GLN F C   1 
ATOM   1214 O O   . GLN A 1 189 ? 163.90400 324.14600 -9.58000  1.000 63.76465  ? 224 GLN F O   1 
ATOM   1215 C CB  . GLN A 1 189 ? 162.30000 324.33300 -12.48400 1.000 63.58758  ? 224 GLN F CB  1 
ATOM   1216 C CG  . GLN A 1 189 ? 162.72000 324.32200 -13.93600 1.000 76.23262  ? 224 GLN F CG  1 
ATOM   1217 C CD  . GLN A 1 189 ? 161.86400 325.17100 -14.85200 1.000 82.91692  ? 224 GLN F CD  1 
ATOM   1218 O OE1 . GLN A 1 189 ? 162.03800 325.13200 -16.08400 1.000 79.88159  ? 224 GLN F OE1 1 
ATOM   1219 N NE2 . GLN A 1 189 ? 160.89700 325.89900 -14.27500 1.000 79.16408  ? 224 GLN F NE2 1 
ATOM   1220 N N   . GLN A 1 190 ? 162.08800 322.80000 -9.56300  1.000 63.85664  ? 225 GLN F N   1 
ATOM   1221 C CA  . GLN A 1 190 ? 161.93300 322.90600 -8.11300  1.000 62.69904  ? 225 GLN F CA  1 
ATOM   1222 C C   . GLN A 1 190 ? 163.10900 322.28100 -7.37800  1.000 65.63716  ? 225 GLN F C   1 
ATOM   1223 O O   . GLN A 1 190 ? 163.61800 322.86300 -6.41600  1.000 68.28660  ? 225 GLN F O   1 
ATOM   1224 C CB  . GLN A 1 190 ? 160.63000 322.24900 -7.65000  1.000 63.20992  ? 225 GLN F CB  1 
ATOM   1225 C CG  . GLN A 1 190 ? 159.33600 322.82800 -8.21600  1.000 71.63307  ? 225 GLN F CG  1 
ATOM   1226 C CD  . GLN A 1 190 ? 159.04200 324.23500 -7.73800  1.000 78.74191  ? 225 GLN F CD  1 
ATOM   1227 O OE1 . GLN A 1 190 ? 159.09500 325.19500 -8.51600  1.000 81.78798  ? 225 GLN F OE1 1 
ATOM   1228 N NE2 . GLN A 1 190 ? 158.71900 324.36700 -6.45600  1.000 80.92118  ? 225 GLN F NE2 1 
ATOM   1229 N N   . LYS A 1 191 ? 163.55600 321.09700 -7.80100  1.000 64.34992  ? 226 LYS F N   1 
ATOM   1230 C CA  . LYS A 1 191 ? 164.68800 320.47700 -7.11700  1.000 64.91654  ? 226 LYS F CA  1 
ATOM   1231 C C   . LYS A 1 191 ? 165.99200 321.21700 -7.38700  1.000 65.77564  ? 226 LYS F C   1 
ATOM   1232 O O   . LYS A 1 191 ? 166.82000 321.37900 -6.48300  1.000 68.22345  ? 226 LYS F O   1 
ATOM   1233 C CB  . LYS A 1 191 ? 164.85400 319.00400 -7.48200  1.000 69.53637  ? 226 LYS F CB  1 
ATOM   1234 C CG  . LYS A 1 191 ? 163.91600 318.05600 -6.78900  1.000 75.46873  ? 226 LYS F CG  1 
ATOM   1235 C CD  . LYS A 1 191 ? 164.52400 316.65600 -6.89000  1.000 79.35130  ? 226 LYS F CD  1 
ATOM   1236 C CE  . LYS A 1 191 ? 163.82600 315.64400 -6.00100  1.000 81.45751  ? 226 LYS F CE  1 
ATOM   1237 N NZ  . LYS A 1 191 ? 164.78000 315.18100 -4.93000  1.000 84.67747  ? 226 LYS F NZ  1 
ATOM   1238 N N   . ASN A 1 192 ? 166.20900 321.65600 -8.61900  1.000 62.70698  ? 227 ASN F N   1 
ATOM   1239 C CA  . ASN A 1 192 ? 167.46000 322.30900 -8.95700  1.000 59.01670  ? 227 ASN F CA  1 
ATOM   1240 C C   . ASN A 1 192 ? 167.56800 323.69500 -8.30700  1.000 60.84977  ? 227 ASN F C   1 
ATOM   1241 O O   . ASN A 1 192 ? 168.68300 324.21900 -8.15700  1.000 59.33430  ? 227 ASN F O   1 
ATOM   1242 C CB  . ASN A 1 192 ? 167.51100 322.49200 -10.46800 1.000 51.02567  ? 227 ASN F CB  1 
ATOM   1243 C CG  . ASN A 1 192 ? 168.86400 322.84800 -10.96300 1.000 55.67546  ? 227 ASN F CG  1 
ATOM   1244 O OD1 . ASN A 1 192 ? 169.85400 322.40300 -10.39300 1.000 60.53915  ? 227 ASN F OD1 1 
ATOM   1245 N ND2 . ASN A 1 192 ? 168.93800 323.69700 -11.98200 1.000 53.86550  ? 227 ASN F ND2 1 
ATOM   1246 N N   . ASN A 1 193 ? 166.44900 324.25800 -7.83800  1.000 58.62025  ? 228 ASN F N   1 
ATOM   1247 C CA  . ASN A 1 193 ? 166.46900 325.62900 -7.34300  1.000 59.08144  ? 228 ASN F CA  1 
ATOM   1248 C C   . ASN A 1 193 ? 167.38700 325.79400 -6.13500  1.000 65.46773  ? 228 ASN F C   1 
ATOM   1249 O O   . ASN A 1 193 ? 168.16700 326.75300 -6.07300  1.000 63.61785  ? 228 ASN F O   1 
ATOM   1250 C CB  . ASN A 1 193 ? 165.05500 326.03600 -6.93000  1.000 58.31382  ? 228 ASN F CB  1 
ATOM   1251 C CG  . ASN A 1 193 ? 164.97100 327.48900 -6.42300  1.000 65.32760  ? 228 ASN F CG  1 
ATOM   1252 O OD1 . ASN A 1 193 ? 165.52500 328.39800 -7.03400  1.000 66.89865  ? 228 ASN F OD1 1 
ATOM   1253 N ND2 . ASN A 1 193 ? 164.31100 327.69500 -5.27600  1.000 65.23112  ? 228 ASN F ND2 1 
ATOM   1254 N N   . ARG A 1 194 ? 167.32300 324.87200 -5.17800  1.000 61.05057  ? 229 ARG F N   1 
ATOM   1255 C CA  . ARG A 1 194 ? 168.13900 325.02000 -3.98900  1.000 62.21250  ? 229 ARG F CA  1 
ATOM   1256 C C   . ARG A 1 194 ? 169.63900 324.96900 -4.32500  1.000 65.84427  ? 229 ARG F C   1 
ATOM   1257 O O   . ARG A 1 194 ? 170.44800 325.70700 -3.74100  1.000 65.74992  ? 229 ARG F O   1 
ATOM   1258 C CB  . ARG A 1 194 ? 167.81000 323.87700 -3.05100  1.000 63.31067  ? 229 ARG F CB  1 
ATOM   1259 C CG  . ARG A 1 194 ? 168.49800 324.02200 -1.75500  1.000 68.76626  ? 229 ARG F CG  1 
ATOM   1260 C CD  . ARG A 1 194 ? 168.14700 322.92800 -0.76300  1.000 72.00121  ? 229 ARG F CD  1 
ATOM   1261 N NE  . ARG A 1 194 ? 168.64200 323.21800 0.57700   1.000 67.35091  ? 229 ARG F NE  1 
ATOM   1262 C CZ  . ARG A 1 194 ? 168.44100 322.45400 1.64300   1.000 75.32875  ? 229 ARG F CZ  1 
ATOM   1263 N NH1 . ARG A 1 194 ? 167.76500 321.32300 1.56100   1.000 76.13438  ? 229 ARG F NH1 1 
ATOM   1264 N NH2 . ARG A 1 194 ? 169.03000 322.77600 2.79800   1.000 71.70097  ? 229 ARG F NH2 1 
ATOM   1265 N N   . LEU A 1 195 ? 170.03100 324.15700 -5.31600  1.000 60.65614  ? 230 LEU F N   1 
ATOM   1266 C CA  . LEU A 1 195 ? 171.43900 324.14300 -5.71800  1.000 53.00674  ? 230 LEU F CA  1 
ATOM   1267 C C   . LEU A 1 195 ? 171.82400 325.49500 -6.28500  1.000 62.78374  ? 230 LEU F C   1 
ATOM   1268 O O   . LEU A 1 195 ? 172.91200 326.02700 -6.00100  1.000 58.07834  ? 230 LEU F O   1 
ATOM   1269 C CB  . LEU A 1 195 ? 171.72300 323.03900 -6.73700  1.000 54.46917  ? 230 LEU F CB  1 
ATOM   1270 C CG  . LEU A 1 195 ? 173.12900 323.00000 -7.32400  1.000 55.69353  ? 230 LEU F CG  1 
ATOM   1271 C CD1 . LEU A 1 195 ? 174.11300 322.77300 -6.22600  1.000 52.94450  ? 230 LEU F CD1 1 
ATOM   1272 C CD2 . LEU A 1 195 ? 173.20500 321.89500 -8.36100  1.000 53.34968  ? 230 LEU F CD2 1 
ATOM   1273 N N   . LEU A 1 196 ? 170.94500 326.06200 -7.11000  1.000 59.46826  ? 231 LEU F N   1 
ATOM   1274 C CA  . LEU A 1 196 ? 171.28900 327.35200 -7.70200  1.000 62.16208  ? 231 LEU F CA  1 
ATOM   1275 C C   . LEU A 1 196 ? 171.37900 328.47300 -6.64300  1.000 62.86207  ? 231 LEU F C   1 
ATOM   1276 O O   . LEU A 1 196 ? 172.27600 329.32300 -6.70100  1.000 62.87627  ? 231 LEU F O   1 
ATOM   1277 C CB  . LEU A 1 196 ? 170.26700 327.71300 -8.77300  1.000 51.60334  ? 231 LEU F CB  1 
ATOM   1278 C CG  . LEU A 1 196 ? 170.01300 326.67800 -9.87600  1.000 57.12642  ? 231 LEU F CG  1 
ATOM   1279 C CD1 . LEU A 1 196 ? 169.07500 327.30600 -10.88800 1.000 53.70208  ? 231 LEU F CD1 1 
ATOM   1280 C CD2 . LEU A 1 196 ? 171.26400 326.10200 -10.53800 1.000 52.71233  ? 231 LEU F CD2 1 
ATOM   1281 N N   . GLU A 1 197 ? 170.49500 328.47200 -5.64400  1.000 55.76736  ? 232 GLU F N   1 
ATOM   1282 C CA  . GLU A 1 197 ? 170.55900 329.53800 -4.64500  1.000 65.02373  ? 232 GLU F CA  1 
ATOM   1283 C C   . GLU A 1 197 ? 171.76100 329.37500 -3.73300  1.000 61.88111  ? 232 GLU F C   1 
ATOM   1284 O O   . GLU A 1 197 ? 172.39200 330.36700 -3.34300  1.000 64.36128  ? 232 GLU F O   1 
ATOM   1285 C CB  . GLU A 1 197 ? 169.28200 329.62600 -3.81400  1.000 62.44306  ? 232 GLU F CB  1 
ATOM   1286 C CG  . GLU A 1 197 ? 168.08300 329.95700 -4.64400  1.000 64.06134  ? 232 GLU F CG  1 
ATOM   1287 C CD  . GLU A 1 197 ? 168.07400 331.41600 -5.09000  1.000 75.95408  ? 232 GLU F CD  1 
ATOM   1288 O OE1 . GLU A 1 197 ? 168.93300 332.20300 -4.62600  1.000 72.81314  ? 232 GLU F OE1 1 
ATOM   1289 O OE2 . GLU A 1 197 ? 167.20600 331.76600 -5.92100  1.000 79.19265  ? 232 GLU F OE2 1 
ATOM   1290 N N   . ILE A 1 198 ? 172.14900 328.13600 -3.46900  1.000 60.22837  ? 233 ILE F N   1 
ATOM   1291 C CA  . ILE A 1 198 ? 173.30800 327.90900 -2.63700  1.000 56.97338  ? 233 ILE F CA  1 
ATOM   1292 C C   . ILE A 1 198 ? 174.54500 328.35500 -3.38000  1.000 63.58187  ? 233 ILE F C   1 
ATOM   1293 O O   . ILE A 1 198 ? 175.45800 328.94900 -2.78600  1.000 65.21685  ? 233 ILE F O   1 
ATOM   1294 C CB  . ILE A 1 198 ? 173.35600 326.43400 -2.20500  1.000 57.04679  ? 233 ILE F CB  1 
ATOM   1295 C CG1 . ILE A 1 198 ? 172.22000 326.16400 -1.20800  1.000 58.72984  ? 233 ILE F CG1 1 
ATOM   1296 C CG2 . ILE A 1 198 ? 174.70900 326.05900 -1.67200  1.000 54.63127  ? 233 ILE F CG2 1 
ATOM   1297 C CD1 . ILE A 1 198 ? 172.09600 324.72500 -0.76800  1.000 56.84876  ? 233 ILE F CD1 1 
ATOM   1298 N N   . THR A 1 199 ? 174.60900 328.07700 -4.68600  1.000 58.96097  ? 234 THR F N   1 
ATOM   1299 C CA  . THR A 1 199 ? 175.73300 328.58700 -5.44800  1.000 58.92615  ? 234 THR F CA  1 
ATOM   1300 C C   . THR A 1 199 ? 175.74100 330.10700 -5.46700  1.000 60.74285  ? 234 THR F C   1 
ATOM   1301 O O   . THR A 1 199 ? 176.80800 330.71300 -5.38300  1.000 62.53238  ? 234 THR F O   1 
ATOM   1302 C CB  . THR A 1 199 ? 175.66900 328.05600 -6.88900  1.000 62.14580  ? 234 THR F CB  1 
ATOM   1303 O OG1 . THR A 1 199 ? 175.46600 326.63500 -6.88900  1.000 64.97155  ? 234 THR F OG1 1 
ATOM   1304 C CG2 . THR A 1 199 ? 176.88300 328.43400 -7.69300  1.000 62.72710  ? 234 THR F CG2 1 
ATOM   1305 N N   . ARG A 1 200 ? 174.57600 330.74600 -5.47300  1.000 58.88134  ? 235 ARG F N   1 
ATOM   1306 C CA  . ARG A 1 200 ? 174.58600 332.20800 -5.45000  1.000 65.82860  ? 235 ARG F CA  1 
ATOM   1307 C C   . ARG A 1 200 ? 175.13100 332.76900 -4.13100  1.000 62.66041  ? 235 ARG F C   1 
ATOM   1308 O O   . ARG A 1 200 ? 176.00200 333.65700 -4.13500  1.000 62.30007  ? 235 ARG F O   1 
ATOM   1309 C CB  . ARG A 1 200 ? 173.22100 332.76600 -5.83700  1.000 64.47282  ? 235 ARG F CB  1 
ATOM   1310 C CG  . ARG A 1 200 ? 173.40200 334.21100 -6.25100  1.000 71.81620  ? 235 ARG F CG  1 
ATOM   1311 C CD  . ARG A 1 200 ? 172.17200 334.89900 -6.78300  1.000 79.92677  ? 235 ARG F CD  1 
ATOM   1312 N NE  . ARG A 1 200 ? 171.60900 334.12500 -7.87900  1.000 82.49769  ? 235 ARG F NE  1 
ATOM   1313 C CZ  . ARG A 1 200 ? 170.33900 333.77700 -8.00600  1.000 82.44293  ? 235 ARG F CZ  1 
ATOM   1314 N NH1 . ARG A 1 200 ? 169.43400 334.11500 -7.09800  1.000 81.21041  ? 235 ARG F NH1 1 
ATOM   1315 N NH2 . ARG A 1 200 ? 169.95900 333.10200 -9.09300  1.000 83.20164  ? 235 ARG F NH2 1 
ATOM   1316 N N   . GLU A 1 201 ? 174.70100 332.21300 -2.99700  1.000 62.67613  ? 236 GLU F N   1 
ATOM   1317 C CA  . GLU A 1 201 ? 175.19300 332.73200 -1.72500  1.000 57.94055  ? 236 GLU F CA  1 
ATOM   1318 C C   . GLU A 1 201 ? 176.67200 332.44000 -1.56400  1.000 64.03800  ? 236 GLU F C   1 
ATOM   1319 O O   . GLU A 1 201 ? 177.42200 333.30200 -1.10200  1.000 64.17791  ? 236 GLU F O   1 
ATOM   1320 C CB  . GLU A 1 201 ? 174.39400 332.16700 -0.55800  1.000 57.47660  ? 236 GLU F CB  1 
ATOM   1321 C CG  . GLU A 1 201 ? 172.92700 332.46000 -0.65900  1.000 51.07501  ? 236 GLU F CG  1 
ATOM   1322 C CD  . GLU A 1 201 ? 172.14400 331.95100 0.53500   1.000 67.01870  ? 236 GLU F CD  1 
ATOM   1323 O OE1 . GLU A 1 201 ? 172.76600 331.63100 1.57500   1.000 63.94818  ? 236 GLU F OE1 1 
ATOM   1324 O OE2 . GLU A 1 201 ? 170.89100 331.95300 0.46300   1.000 68.46441  ? 236 GLU F OE2 1 
ATOM   1325 N N   . PHE A 1 202 ? 177.12400 331.24700 -1.94000  1.000 64.65452  ? 237 PHE F N   1 
ATOM   1326 C CA  . PHE A 1 202 ? 178.54000 330.95400 -1.77500  1.000 60.70683  ? 237 PHE F CA  1 
ATOM   1327 C C   . PHE A 1 202 ? 179.39300 331.78900 -2.73600  1.000 67.92935  ? 237 PHE F C   1 
ATOM   1328 O O   . PHE A 1 202 ? 180.54000 332.11800 -2.41400  1.000 69.44225  ? 237 PHE F O   1 
ATOM   1329 C CB  . PHE A 1 202 ? 178.79300 329.45900 -1.96300  1.000 66.26468  ? 237 PHE F CB  1 
ATOM   1330 C CG  . PHE A 1 202 ? 178.58600 328.65100 -0.70700  1.000 65.61831  ? 237 PHE F CG  1 
ATOM   1331 C CD1 . PHE A 1 202 ? 178.80200 329.21600 0.54300   1.000 61.73016  ? 237 PHE F CD1 1 
ATOM   1332 C CD2 . PHE A 1 202 ? 178.14000 327.33300 -0.77800  1.000 62.11288  ? 237 PHE F CD2 1 
ATOM   1333 C CE1 . PHE A 1 202 ? 178.60000 328.47400 1.70000   1.000 59.40164  ? 237 PHE F CE1 1 
ATOM   1334 C CE2 . PHE A 1 202 ? 177.92800 326.58400 0.37500   1.000 62.33163  ? 237 PHE F CE2 1 
ATOM   1335 C CZ  . PHE A 1 202 ? 178.15400 327.15400 1.61600   1.000 63.58036  ? 237 PHE F CZ  1 
ATOM   1336 N N   . SER A 1 203 ? 178.85200 332.18300 -3.89900  1.000 63.82882  ? 238 SER F N   1 
ATOM   1337 C CA  . SER A 1 203 ? 179.65000 332.96400 -4.84300  1.000 61.09017  ? 238 SER F CA  1 
ATOM   1338 C C   . SER A 1 203 ? 179.81100 334.41400 -4.42100  1.000 66.80361  ? 238 SER F C   1 
ATOM   1339 O O   . SER A 1 203 ? 180.92600 334.94000 -4.46400  1.000 69.16926  ? 238 SER F O   1 
ATOM   1340 C CB  . SER A 1 203 ? 179.04700 332.92400 -6.24700  1.000 58.69318  ? 238 SER F CB  1 
ATOM   1341 O OG  . SER A 1 203 ? 179.02700 331.59800 -6.74700  1.000 71.12494  ? 238 SER F OG  1 
ATOM   1342 N N   . VAL A 1 204 ? 178.73900 335.06800 -3.96400  1.000 64.58207  ? 239 VAL F N   1 
ATOM   1343 C CA  . VAL A 1 204 ? 178.88300 336.49100 -3.64200  1.000 69.40396  ? 239 VAL F CA  1 
ATOM   1344 C C   . VAL A 1 204 ? 179.67000 336.72400 -2.36100  1.000 68.70178  ? 239 VAL F C   1 
ATOM   1345 O O   . VAL A 1 204 ? 180.16900 337.83500 -2.13500  1.000 66.68162  ? 239 VAL F O   1 
ATOM   1346 C CB  . VAL A 1 204 ? 177.52200 337.19700 -3.50600  1.000 65.09372  ? 239 VAL F CB  1 
ATOM   1347 C CG1 . VAL A 1 204 ? 176.71300 337.01900 -4.76100  1.000 68.12227  ? 239 VAL F CG1 1 
ATOM   1348 C CG2 . VAL A 1 204 ? 176.77500 336.65500 -2.29000  1.000 64.93774  ? 239 VAL F CG2 1 
ATOM   1349 N N   . ASN A 1 205 ? 179.80300 335.69800 -1.52400  1.000 65.71039  ? 240 ASN F N   1 
ATOM   1350 C CA  . ASN A 1 205 ? 180.44100 335.79500 -0.22300  1.000 60.26411  ? 240 ASN F CA  1 
ATOM   1351 C C   . ASN A 1 205 ? 181.73400 334.99800 -0.13500  1.000 60.06744  ? 240 ASN F C   1 
ATOM   1352 O O   . ASN A 1 205 ? 182.17700 334.65500 0.96100   1.000 59.65966  ? 240 ASN F O   1 
ATOM   1353 C CB  . ASN A 1 205 ? 179.42900 335.34500 0.82900   1.000 61.25023  ? 240 ASN F CB  1 
ATOM   1354 C CG  . ASN A 1 205 ? 178.21400 336.26300 0.88900   1.000 64.02377  ? 240 ASN F CG  1 
ATOM   1355 O OD1 . ASN A 1 205 ? 177.07400 335.80600 0.90100   1.000 67.66761  ? 240 ASN F OD1 1 
ATOM   1356 N ND2 . ASN A 1 205 ? 178.45800 337.55800 1.01400   1.000 68.59384  ? 240 ASN F ND2 1 
ATOM   1357 N N   . ALA A 1 206 ? 182.31400 334.62800 -1.26600  1.000 61.52619  ? 241 ALA F N   1 
ATOM   1358 C CA  . ALA A 1 206 ? 183.61800 333.98000 -1.26300  1.000 61.15733  ? 241 ALA F CA  1 
ATOM   1359 C C   . ALA A 1 206 ? 183.63700 332.72300 -0.40700  1.000 60.62005  ? 241 ALA F C   1 
ATOM   1360 O O   . ALA A 1 206 ? 184.63800 332.42400 0.23300   1.000 64.85602  ? 241 ALA F O   1 
ATOM   1361 C CB  . ALA A 1 206 ? 184.70500 334.94800 -0.79400  1.000 69.65561  ? 241 ALA F CB  1 
ATOM   1362 N N   . GLY A 1 207 ? 182.57500 331.92200 -0.48700  1.000 64.32703  ? 242 GLY F N   1 
ATOM   1363 C CA  . GLY A 1 207 ? 182.50100 330.64400 0.20400   1.000 58.43651  ? 242 GLY F CA  1 
ATOM   1364 C C   . GLY A 1 207 ? 182.12700 330.63100 1.68200   1.000 55.41405  ? 242 GLY F C   1 
ATOM   1365 O O   . GLY A 1 207 ? 182.04200 329.53800 2.25600   1.000 53.88962  ? 242 GLY F O   1 
ATOM   1366 N N   . VAL A 1 208 ? 182.00200 331.78100 2.34300   1.000 56.50844  ? 243 VAL F N   1 
ATOM   1367 C CA  . VAL A 1 208 ? 181.65200 331.87300 3.76400   1.000 52.18076  ? 243 VAL F CA  1 
ATOM   1368 C C   . VAL A 1 208 ? 180.44100 332.77400 3.98100   1.000 51.35256  ? 243 VAL F C   1 
ATOM   1369 O O   . VAL A 1 208 ? 180.50200 333.96600 3.66700   1.000 58.44249  ? 243 VAL F O   1 
ATOM   1370 C CB  . VAL A 1 208 ? 182.82900 332.35700 4.61900   1.000 46.94493  ? 243 VAL F CB  1 
ATOM   1371 C CG1 . VAL A 1 208 ? 182.44200 332.30400 6.08200   1.000 48.40181  ? 243 VAL F CG1 1 
ATOM   1372 C CG2 . VAL A 1 208 ? 184.04800 331.49300 4.36000   1.000 42.37778  ? 243 VAL F CG2 1 
ATOM   1373 N N   . THR A 1 209 ? 179.30700 332.20300 4.36900   1.000 46.68707  ? 244 THR F N   1 
ATOM   1374 C CA  . THR A 1 209 ? 178.09900 332.99900 4.55000   1.000 50.15435  ? 244 THR F CA  1 
ATOM   1375 C C   . THR A 1 209 ? 177.65600 333.01300 6.01000   1.000 50.42322  ? 244 THR F C   1 
ATOM   1376 O O   . THR A 1 209 ? 177.84600 332.02700 6.73600   1.000 52.08711  ? 244 THR F O   1 
ATOM   1377 C CB  . THR A 1 209 ? 176.92900 332.47400 3.69300   1.000 56.28581  ? 244 THR F CB  1 
ATOM   1378 O OG1 . THR A 1 209 ? 176.47600 331.20300 4.20100   1.000 60.89280  ? 244 THR F OG1 1 
ATOM   1379 C CG2 . THR A 1 209 ? 177.35800 332.33600 2.22000   1.000 57.96039  ? 244 THR F CG2 1 
ATOM   1380 N N   . THR A 1 210 ? 177.15200 334.16100 6.46700   1.000 44.96568  ? 245 THR F N   1 
ATOM   1381 C CA  . THR A 1 210 ? 176.56300 334.22900 7.80000   1.000 47.64898  ? 245 THR F CA  1 
ATOM   1382 C C   . THR A 1 210 ? 175.66700 335.45700 7.70800   1.000 44.84505  ? 245 THR F C   1 
ATOM   1383 O O   . THR A 1 210 ? 176.10500 336.48100 7.17500   1.000 55.96647  ? 245 THR F O   1 
ATOM   1384 C CB  . THR A 1 210 ? 177.61300 334.35700 8.92300   1.000 50.09062  ? 245 THR F CB  1 
ATOM   1385 O OG1 . THR A 1 210 ? 176.97000 334.56000 10.19300  1.000 45.39098  ? 245 THR F OG1 1 
ATOM   1386 C CG2 . THR A 1 210 ? 178.47200 335.56700 8.68000   1.000 44.80453  ? 245 THR F CG2 1 
ATOM   1387 N N   . PRO A 1 211 ? 174.40600 335.39900 8.14700   1.000 51.22787  ? 246 PRO F N   1 
ATOM   1388 C CA  . PRO A 1 211 ? 173.81200 334.19800 8.74000   1.000 48.54729  ? 246 PRO F CA  1 
ATOM   1389 C C   . PRO A 1 211 ? 173.60200 333.05800 7.73300   1.000 54.61156  ? 246 PRO F C   1 
ATOM   1390 O O   . PRO A 1 211 ? 173.82400 333.18100 6.52400   1.000 51.73334  ? 246 PRO F O   1 
ATOM   1391 C CB  . PRO A 1 211 ? 172.45500 334.68800 9.26000   1.000 48.03164  ? 246 PRO F CB  1 
ATOM   1392 C CG  . PRO A 1 211 ? 172.57200 336.20600 9.28100   1.000 55.72668  ? 246 PRO F CG  1 
ATOM   1393 C CD  . PRO A 1 211 ? 173.47400 336.53800 8.15500   1.000 45.08182  ? 246 PRO F CD  1 
ATOM   1394 N N   . VAL A 1 212 ? 173.25900 331.90400 8.29000   1.000 54.63439  ? 247 VAL F N   1 
ATOM   1395 C CA  . VAL A 1 212 ? 173.00100 330.69000 7.52600   1.000 57.71671  ? 247 VAL F CA  1 
ATOM   1396 C C   . VAL A 1 212 ? 171.54500 330.70200 7.05500   1.000 57.99320  ? 247 VAL F C   1 
ATOM   1397 O O   . VAL A 1 212 ? 170.61700 330.71800 7.87300   1.000 56.94188  ? 247 VAL F O   1 
ATOM   1398 C CB  . VAL A 1 212 ? 173.35000 329.44900 8.35000   1.000 57.68726  ? 247 VAL F CB  1 
ATOM   1399 C CG1 . VAL A 1 212 ? 173.04400 328.18500 7.56100   1.000 60.77505  ? 247 VAL F CG1 1 
ATOM   1400 C CG2 . VAL A 1 212 ? 174.81800 329.50400 8.75800   1.000 50.66003  ? 247 VAL F CG2 1 
ATOM   1401 N N   . SER A 1 213 ? 171.33700 330.76900 5.73800   1.000 61.34169  ? 248 SER F N   1 
ATOM   1402 C CA  . SER A 1 213 ? 169.99100 330.85200 5.18100   1.000 60.38406  ? 248 SER F CA  1 
ATOM   1403 C C   . SER A 1 213 ? 169.24900 329.50700 5.22000   1.000 59.71707  ? 248 SER F C   1 
ATOM   1404 O O   . SER A 1 213 ? 169.81800 328.43900 5.47700   1.000 57.84418  ? 248 SER F O   1 
ATOM   1405 C CB  . SER A 1 213 ? 170.05900 331.30200 3.73500   1.000 58.91825  ? 248 SER F CB  1 
ATOM   1406 O OG  . SER A 1 213 ? 170.78200 330.33100 2.99000   1.000 57.45179  ? 248 SER F OG  1 
ATOM   1407 N N   . THR A 1 214 ? 167.93500 329.58400 4.94900   1.000 64.76630  ? 249 THR F N   1 
ATOM   1408 C CA  . THR A 1 214 ? 167.10800 328.38400 4.83700   1.000 63.22840  ? 249 THR F CA  1 
ATOM   1409 C C   . THR A 1 214 ? 167.49800 327.56600 3.62100   1.000 61.60787  ? 249 THR F C   1 
ATOM   1410 O O   . THR A 1 214 ? 167.21900 326.36300 3.58300   1.000 62.26662  ? 249 THR F O   1 
ATOM   1411 C CB  . THR A 1 214 ? 165.62300 328.74300 4.76100   1.000 63.36917  ? 249 THR F CB  1 
ATOM   1412 O OG1 . THR A 1 214 ? 165.39800 329.60200 3.63300   1.000 71.38883  ? 249 THR F OG1 1 
ATOM   1413 C CG2 . THR A 1 214 ? 165.12800 329.38800 6.06400   1.000 59.80570  ? 249 THR F CG2 1 
ATOM   1414 N N   . TYR A 1 215 ? 168.16300 328.19300 2.64100   1.000 59.70741  ? 250 TYR F N   1 
ATOM   1415 C CA  . TYR A 1 215 ? 168.71900 327.45100 1.51500   1.000 60.52436  ? 250 TYR F CA  1 
ATOM   1416 C C   . TYR A 1 215 ? 169.89300 326.60300 1.95800   1.000 63.23419  ? 250 TYR F C   1 
ATOM   1417 O O   . TYR A 1 215 ? 170.04400 325.45600 1.51700   1.000 61.18057  ? 250 TYR F O   1 
ATOM   1418 C CB  . TYR A 1 215 ? 169.15800 328.42500 0.41900   1.000 64.32142  ? 250 TYR F CB  1 
ATOM   1419 C CG  . TYR A 1 215 ? 168.02500 329.12200 -0.30900  1.000 70.20361  ? 250 TYR F CG  1 
ATOM   1420 C CD1 . TYR A 1 215 ? 166.85000 328.43700 -0.60500  1.000 69.87925  ? 250 TYR F CD1 1 
ATOM   1421 C CD2 . TYR A 1 215 ? 168.11100 330.47200 -0.66000  1.000 70.44928  ? 250 TYR F CD2 1 
ATOM   1422 C CE1 . TYR A 1 215 ? 165.81000 329.04900 -1.26400  1.000 71.80091  ? 250 TYR F CE1 1 
ATOM   1423 C CE2 . TYR A 1 215 ? 167.06400 331.10400 -1.31700  1.000 74.18911  ? 250 TYR F CE2 1 
ATOM   1424 C CZ  . TYR A 1 215 ? 165.91300 330.38000 -1.61200  1.000 76.50719  ? 250 TYR F CZ  1 
ATOM   1425 O OH  . TYR A 1 215 ? 164.86600 330.98500 -2.27200  1.000 80.95581  ? 250 TYR F OH  1 
ATOM   1426 N N   . MET A 1 216 ? 170.75400 327.16200 2.81400   1.000 61.55454  ? 251 MET F N   1 
ATOM   1427 C CA  . MET A 1 216 ? 171.84500 326.36600 3.35500   1.000 59.87907  ? 251 MET F CA  1 
ATOM   1428 C C   . MET A 1 216 ? 171.31800 325.28000 4.27500   1.000 57.07653  ? 251 MET F C   1 
ATOM   1429 O O   . MET A 1 216 ? 171.80000 324.14800 4.24300   1.000 56.27259  ? 251 MET F O   1 
ATOM   1430 C CB  . MET A 1 216 ? 172.83000 327.27100 4.09600   1.000 61.39814  ? 251 MET F CB  1 
ATOM   1431 C CG  . MET A 1 216 ? 173.55100 328.25000 3.20100   1.000 53.37190  ? 251 MET F CG  1 
ATOM   1432 S SD  . MET A 1 216 ? 174.81600 327.40400 2.25600   1.000 59.21760  ? 251 MET F SD  1 
ATOM   1433 C CE  . MET A 1 216 ? 175.35600 328.73900 1.19200   1.000 56.46209  ? 251 MET F CE  1 
ATOM   1434 N N   . LEU A 1 217 ? 170.32300 325.58900 5.09200   1.000 56.77197  ? 252 LEU F N   1 
ATOM   1435 C CA  . LEU A 1 217 ? 169.85700 324.57800 6.02300   1.000 59.33671  ? 252 LEU F CA  1 
ATOM   1436 C C   . LEU A 1 217 ? 168.41100 324.94900 6.32400   1.000 61.94682  ? 252 LEU F C   1 
ATOM   1437 O O   . LEU A 1 217 ? 168.18900 326.01000 6.89700   1.000 63.84184  ? 252 LEU F O   1 
ATOM   1438 C CB  . LEU A 1 217 ? 170.73300 324.60100 7.28200   1.000 65.61107  ? 252 LEU F CB  1 
ATOM   1439 C CG  . LEU A 1 217 ? 170.85700 323.38700 8.18400   1.000 63.34388  ? 252 LEU F CG  1 
ATOM   1440 C CD1 . LEU A 1 217 ? 171.53800 322.35800 7.26800   1.000 65.82355  ? 252 LEU F CD1 1 
ATOM   1441 C CD2 . LEU A 1 217 ? 171.59800 323.60000 9.47700   1.000 66.67816  ? 252 LEU F CD2 1 
ATOM   1442 N N   . THR A 1 218 ? 167.42100 324.13800 5.93900   1.000 68.82505  ? 253 THR F N   1 
ATOM   1443 C CA  . THR A 1 218 ? 166.03700 324.53500 6.23400   1.000 68.42649  ? 253 THR F CA  1 
ATOM   1444 C C   . THR A 1 218 ? 165.78600 324.52200 7.73900   1.000 67.81192  ? 253 THR F C   1 
ATOM   1445 O O   . THR A 1 218 ? 166.44500 323.80500 8.49700   1.000 66.64167  ? 253 THR F O   1 
ATOM   1446 C CB  . THR A 1 218 ? 164.97400 323.65100 5.55300   1.000 70.74664  ? 253 THR F CB  1 
ATOM   1447 O OG1 . THR A 1 218 ? 164.67300 322.51600 6.38500   1.000 73.78717  ? 253 THR F OG1 1 
ATOM   1448 C CG2 . THR A 1 218 ? 165.36200 323.22600 4.13300   1.000 67.26646  ? 253 THR F CG2 1 
ATOM   1449 N N   . ASN A 1 219 ? 164.78800 325.30200 8.16400   1.000 63.61587  ? 254 ASN F N   1 
ATOM   1450 C CA  . ASN A 1 219 ? 164.42800 325.31700 9.57500   1.000 65.06131  ? 254 ASN F CA  1 
ATOM   1451 C C   . ASN A 1 219 ? 164.13000 323.91900 10.07300  1.000 71.03387  ? 254 ASN F C   1 
ATOM   1452 O O   . ASN A 1 219 ? 164.51200 323.55700 11.19400  1.000 66.60558  ? 254 ASN F O   1 
ATOM   1453 C CB  . ASN A 1 219 ? 163.22700 326.23100 9.79800   1.000 67.59766  ? 254 ASN F CB  1 
ATOM   1454 C CG  . ASN A 1 219 ? 163.56600 327.69400 9.59600   1.000 74.23188  ? 254 ASN F CG  1 
ATOM   1455 O OD1 . ASN A 1 219 ? 162.78700 328.45200 9.02200   1.000 74.39488  ? 254 ASN F OD1 1 
ATOM   1456 N ND2 . ASN A 1 219 ? 164.71300 328.11500 10.13200  1.000 72.15845  ? 254 ASN F ND2 1 
ATOM   1457 N N   . SER A 1 220 ? 163.50600 323.09700 9.23400   1.000 71.52694  ? 255 SER F N   1 
ATOM   1458 C CA  . SER A 1 220 ? 163.28200 321.71300 9.61900   1.000 69.12656  ? 255 SER F CA  1 
ATOM   1459 C C   . SER A 1 220 ? 164.60200 320.97100 9.80100   1.000 66.72084  ? 255 SER F C   1 
ATOM   1460 O O   . SER A 1 220 ? 164.78900 320.23300 10.78500  1.000 65.84104  ? 255 SER F O   1 
ATOM   1461 C CB  . SER A 1 220 ? 162.41800 321.03300 8.55900   1.000 75.90411  ? 255 SER F CB  1 
ATOM   1462 O OG  . SER A 1 220 ? 162.29400 319.64800 8.80800   1.000 79.61486  ? 255 SER F OG  1 
ATOM   1463 N N   . GLU A 1 221 ? 165.55900 321.20100 8.89900   1.000 65.34188  ? 256 GLU F N   1 
ATOM   1464 C CA  . GLU A 1 221 ? 166.84900 320.52600 9.03000   1.000 67.31392  ? 256 GLU F CA  1 
ATOM   1465 C C   . GLU A 1 221 ? 167.64700 321.07700 10.20700  1.000 68.94765  ? 256 GLU F C   1 
ATOM   1466 O O   . GLU A 1 221 ? 168.36800 320.33100 10.87600  1.000 66.13114  ? 256 GLU F O   1 
ATOM   1467 C CB  . GLU A 1 221 ? 167.63500 320.68100 7.73100   1.000 71.47172  ? 256 GLU F CB  1 
ATOM   1468 C CG  . GLU A 1 221 ? 166.82600 320.25700 6.50600   1.000 75.80949  ? 256 GLU F CG  1 
ATOM   1469 C CD  . GLU A 1 221 ? 167.48300 320.65600 5.20800   1.000 75.73377  ? 256 GLU F CD  1 
ATOM   1470 O OE1 . GLU A 1 221 ? 167.40900 321.84600 4.85400   1.000 75.40747  ? 256 GLU F OE1 1 
ATOM   1471 O OE2 . GLU A 1 221 ? 168.01500 319.77000 4.50800   1.000 78.12666  ? 256 GLU F OE2 1 
ATOM   1472 N N   . LEU A 1 222 ? 167.49800 322.36600 10.50400  1.000 69.18185  ? 257 LEU F N   1 
ATOM   1473 C CA  . LEU A 1 222 ? 168.23400 322.94100 11.61700  1.000 66.16018  ? 257 LEU F CA  1 
ATOM   1474 C C   . LEU A 1 222 ? 167.70900 322.38700 12.92900  1.000 65.19784  ? 257 LEU F C   1 
ATOM   1475 O O   . LEU A 1 222 ? 168.49400 322.00900 13.80300  1.000 62.07910  ? 257 LEU F O   1 
ATOM   1476 C CB  . LEU A 1 222 ? 168.12700 324.45500 11.60800  1.000 57.99210  ? 257 LEU F CB  1 
ATOM   1477 C CG  . LEU A 1 222 ? 168.82900 325.13600 12.78600  1.000 61.63795  ? 257 LEU F CG  1 
ATOM   1478 C CD1 . LEU A 1 222 ? 170.32400 324.82300 12.84000  1.000 52.66817  ? 257 LEU F CD1 1 
ATOM   1479 C CD2 . LEU A 1 222 ? 168.53900 326.63900 12.77500  1.000 53.50491  ? 257 LEU F CD2 1 
ATOM   1480 N N   . LEU A 1 223 ? 166.38400 322.32000 13.07900  1.000 59.83103  ? 258 LEU F N   1 
ATOM   1481 C CA  . LEU A 1 223 ? 165.80800 321.78700 14.30900  1.000 62.20993  ? 258 LEU F CA  1 
ATOM   1482 C C   . LEU A 1 223 ? 166.17600 320.32700 14.49700  1.000 66.54097  ? 258 LEU F C   1 
ATOM   1483 O O   . LEU A 1 223 ? 166.43000 319.88500 15.62500  1.000 68.40713  ? 258 LEU F O   1 
ATOM   1484 C CB  . LEU A 1 223 ? 164.28900 321.93000 14.27600  1.000 62.97967  ? 258 LEU F CB  1 
ATOM   1485 C CG  . LEU A 1 223 ? 163.62700 323.30200 14.36200  1.000 62.84371  ? 258 LEU F CG  1 
ATOM   1486 C CD1 . LEU A 1 223 ? 162.11600 323.19400 14.12500  1.000 63.82898  ? 258 LEU F CD1 1 
ATOM   1487 C CD2 . LEU A 1 223 ? 163.91800 323.92200 15.71800  1.000 58.89294  ? 258 LEU F CD2 1 
ATOM   1488 N N   . SER A 1 224 ? 166.17500 319.54800 13.41200  1.000 69.74809  ? 259 SER F N   1 
ATOM   1489 C CA  . SER A 1 224 ? 166.62700 318.16400 13.52200  1.000 70.21558  ? 259 SER F CA  1 
ATOM   1490 C C   . SER A 1 224 ? 168.10700 318.06900 13.84500  1.000 67.74953  ? 259 SER F C   1 
ATOM   1491 O O   . SER A 1 224 ? 168.54000 317.09800 14.47300  1.000 74.21759  ? 259 SER F O   1 
ATOM   1492 C CB  . SER A 1 224 ? 166.29800 317.39300 12.24700  1.000 74.43816  ? 259 SER F CB  1 
ATOM   1493 O OG  . SER A 1 224 ? 164.90100 317.43400 12.01700  1.000 78.29509  ? 259 SER F OG  1 
ATOM   1494 N N   . LEU A 1 225 ? 168.91100 319.01400 13.36500  1.000 66.38574  ? 260 LEU F N   1 
ATOM   1495 C CA  . LEU A 1 225 ? 170.33100 318.97900 13.68900  1.000 68.01863  ? 260 LEU F CA  1 
ATOM   1496 C C   . LEU A 1 225 ? 170.58800 319.37700 15.13600  1.000 69.70878  ? 260 LEU F C   1 
ATOM   1497 O O   . LEU A 1 225 ? 171.49600 318.84900 15.78500  1.000 72.90229  ? 260 LEU F O   1 
ATOM   1498 C CB  . LEU A 1 225 ? 171.07400 319.90300 12.74100  1.000 67.02887  ? 260 LEU F CB  1 
ATOM   1499 C CG  . LEU A 1 225 ? 172.57600 319.84000 12.89500  1.000 70.27093  ? 260 LEU F CG  1 
ATOM   1500 C CD1 . LEU A 1 225 ? 173.00000 318.39300 12.90000  1.000 70.70020  ? 260 LEU F CD1 1 
ATOM   1501 C CD2 . LEU A 1 225 ? 173.18300 320.56300 11.71100  1.000 67.23832  ? 260 LEU F CD2 1 
ATOM   1502 N N   . ILE A 1 226 ? 169.80800 320.32000 15.64800  1.000 67.49736  ? 261 ILE F N   1 
ATOM   1503 C CA  . ILE A 1 226 ? 169.93900 320.71800 17.03600  1.000 62.95692  ? 261 ILE F CA  1 
ATOM   1504 C C   . ILE A 1 226 ? 169.53000 319.56300 17.92700  1.000 69.83051  ? 261 ILE F C   1 
ATOM   1505 O O   . ILE A 1 226 ? 170.22300 319.21200 18.88900  1.000 67.51366  ? 261 ILE F O   1 
ATOM   1506 C CB  . ILE A 1 226 ? 169.03500 321.93200 17.28900  1.000 56.93502  ? 261 ILE F CB  1 
ATOM   1507 C CG1 . ILE A 1 226 ? 169.52100 323.16100 16.53300  1.000 50.32376  ? 261 ILE F CG1 1 
ATOM   1508 C CG2 . ILE A 1 226 ? 168.90300 322.19000 18.76900  1.000 54.62843  ? 261 ILE F CG2 1 
ATOM   1509 C CD1 . ILE A 1 226 ? 168.84600 324.38300 16.98500  1.000 49.24071  ? 261 ILE F CD1 1 
ATOM   1510 N N   . ASN A 1 227 ? 168.44000 318.88800 17.55500  1.000 70.11171  ? 262 ASN F N   1 
ATOM   1511 C CA  . ASN A 1 227 ? 167.91200 317.84000 18.40900  1.000 72.20320  ? 262 ASN F CA  1 
ATOM   1512 C C   . ASN A 1 227 ? 168.89600 316.69200 18.52200  1.000 72.16533  ? 262 ASN F C   1 
ATOM   1513 O O   . ASN A 1 227 ? 168.88500 315.94500 19.50800  1.000 70.05572  ? 262 ASN F O   1 
ATOM   1514 C CB  . ASN A 1 227 ? 166.57000 317.36800 17.85200  1.000 77.67882  ? 262 ASN F CB  1 
ATOM   1515 C CG  . ASN A 1 227 ? 166.03500 316.15300 18.57100  1.000 80.62504  ? 262 ASN F CG  1 
ATOM   1516 O OD1 . ASN A 1 227 ? 165.77000 316.18700 19.77500  1.000 79.22314  ? 262 ASN F OD1 1 
ATOM   1517 N ND2 . ASN A 1 227 ? 165.87300 315.06200 17.83000  1.000 85.51526  ? 262 ASN F ND2 1 
ATOM   1518 N N   . ASP A 1 228 ? 169.72300 316.52400 17.50100  1.000 73.57453  ? 263 ASP F N   1 
ATOM   1519 C CA  . ASP A 1 228 ? 170.65600 315.42200 17.39600  1.000 74.17205  ? 263 ASP F CA  1 
ATOM   1520 C C   . ASP A 1 228 ? 172.06200 315.76900 17.89700  1.000 76.97802  ? 263 ASP F C   1 
ATOM   1521 O O   . ASP A 1 228 ? 173.00300 315.00300 17.66500  1.000 81.21517  ? 263 ASP F O   1 
ATOM   1522 C CB  . ASP A 1 228 ? 170.68500 314.99200 15.93200  1.000 79.54943  ? 263 ASP F CB  1 
ATOM   1523 C CG  . ASP A 1 228 ? 169.60100 313.97400 15.61800  1.000 83.23059  ? 263 ASP F CG  1 
ATOM   1524 O OD1 . ASP A 1 228 ? 169.41500 313.02600 16.40900  1.000 89.23141  ? 263 ASP F OD1 1 
ATOM   1525 O OD2 . ASP A 1 228 ? 168.88000 314.19100 14.60500  1.000 77.43999  ? 263 ASP F OD2 1 
ATOM   1526 N N   . MET A 1 229 ? 172.23600 316.90300 18.55800  1.000 73.23228  ? 264 MET F N   1 
ATOM   1527 C CA  . MET A 1 229 ? 173.51300 317.46600 19.03700  1.000 74.72210  ? 264 MET F CA  1 
ATOM   1528 C C   . MET A 1 229 ? 173.88600 316.89000 20.40200  1.000 71.71552  ? 264 MET F C   1 
ATOM   1529 O O   . MET A 1 229 ? 172.99600 316.59100 21.21900  1.000 70.57938  ? 264 MET F O   1 
ATOM   1530 C CB  . MET A 1 229 ? 173.44000 318.99500 19.10300  1.000 70.44671  ? 264 MET F CB  1 
ATOM   1531 C CG  . MET A 1 229 ? 173.60800 319.70700 17.74700  1.000 69.54775  ? 264 MET F CG  1 
ATOM   1532 S SD  . MET A 1 229 ? 173.66400 321.51700 17.90400  1.000 72.70952  ? 264 MET F SD  1 
ATOM   1533 C CE  . MET A 1 229 ? 175.42100 321.84900 17.97400  1.000 63.53377  ? 264 MET F CE  1 
ATOM   1534 N N   . PRO A 1 230 ? 175.19700 316.75500 20.68900  1.000 74.28027  ? 265 PRO F N   1 
ATOM   1535 C CA  . PRO A 1 230 ? 175.63200 316.27100 22.01800  1.000 69.30718  ? 265 PRO F CA  1 
ATOM   1536 C C   . PRO A 1 230 ? 175.56400 317.35600 23.09400  1.000 64.82085  ? 265 PRO F C   1 
ATOM   1537 O O   . PRO A 1 230 ? 176.55600 317.73200 23.72900  1.000 66.99163  ? 265 PRO F O   1 
ATOM   1538 C CB  . PRO A 1 230 ? 177.05900 315.77800 21.73700  1.000 72.40172  ? 265 PRO F CB  1 
ATOM   1539 C CG  . PRO A 1 230 ? 177.53000 316.68000 20.61300  1.000 74.06363  ? 265 PRO F CG  1 
ATOM   1540 C CD  . PRO A 1 230 ? 176.31600 317.00500 19.77500  1.000 74.18222  ? 265 PRO F CD  1 
ATOM   1541 N N   . ILE A 1 231 ? 174.35800 317.88300 23.30800  1.000 65.03334  ? 266 ILE F N   1 
ATOM   1542 C CA  . ILE A 1 231 ? 174.09000 318.92200 24.29600  1.000 67.24612  ? 266 ILE F CA  1 
ATOM   1543 C C   . ILE A 1 231 ? 172.92100 318.49800 25.17700  1.000 63.28842  ? 266 ILE F C   1 
ATOM   1544 O O   . ILE A 1 231 ? 172.19300 317.55600 24.86800  1.000 59.14457  ? 266 ILE F O   1 
ATOM   1545 C CB  . ILE A 1 231 ? 173.78700 320.29200 23.62800  1.000 64.46202  ? 266 ILE F CB  1 
ATOM   1546 C CG1 . ILE A 1 231 ? 172.64800 320.18700 22.62400  1.000 63.29970  ? 266 ILE F CG1 1 
ATOM   1547 C CG2 . ILE A 1 231 ? 175.01700 320.79800 22.87600  1.000 60.09976  ? 266 ILE F CG2 1 
ATOM   1548 C CD1 . ILE A 1 231 ? 172.26400 321.52100 22.00300  1.000 61.07564  ? 266 ILE F CD1 1 
ATOM   1549 N N   . THR A 1 232 ? 172.76000 319.21600 26.29100  1.000 62.59452  ? 267 THR F N   1 
ATOM   1550 C CA  . THR A 1 232 ? 171.72700 318.91000 27.27200  1.000 60.65640  ? 267 THR F CA  1 
ATOM   1551 C C   . THR A 1 232 ? 170.36000 319.20400 26.66000  1.000 64.70224  ? 267 THR F C   1 
ATOM   1552 O O   . THR A 1 232 ? 170.24900 319.85900 25.62400  1.000 65.49716  ? 267 THR F O   1 
ATOM   1553 C CB  . THR A 1 232 ? 171.94900 319.70300 28.56100  1.000 62.30544  ? 267 THR F CB  1 
ATOM   1554 O OG1 . THR A 1 232 ? 171.60300 321.06800 28.35200  1.000 61.08815  ? 267 THR F OG1 1 
ATOM   1555 C CG2 . THR A 1 232 ? 173.42500 319.62300 29.00300  1.000 59.50670  ? 267 THR F CG2 1 
ATOM   1556 N N   . ASN A 1 233 ? 169.30800 318.65500 27.26500  1.000 66.84893  ? 268 ASN F N   1 
ATOM   1557 C CA  . ASN A 1 233 ? 167.97200 318.93800 26.74200  1.000 63.05465  ? 268 ASN F CA  1 
ATOM   1558 C C   . ASN A 1 233 ? 167.54200 320.39200 26.90200  1.000 63.17230  ? 268 ASN F C   1 
ATOM   1559 O O   . ASN A 1 233 ? 166.88000 320.93100 26.00600  1.000 63.76537  ? 268 ASN F O   1 
ATOM   1560 C CB  . ASN A 1 233 ? 166.97000 318.00000 27.39900  1.000 66.30036  ? 268 ASN F CB  1 
ATOM   1561 C CG  . ASN A 1 233 ? 166.87700 316.67000 26.66100  1.000 75.21460  ? 268 ASN F CG  1 
ATOM   1562 O OD1 . ASN A 1 233 ? 166.00200 316.47300 25.81300  1.000 74.94702  ? 268 ASN F OD1 1 
ATOM   1563 N ND2 . ASN A 1 233 ? 167.83300 315.77800 26.92700  1.000 68.87888  ? 268 ASN F ND2 1 
ATOM   1564 N N   . ASP A 1 234 ? 167.96700 321.08100 27.96400  1.000 65.25714  ? 269 ASP F N   1 
ATOM   1565 C CA  . ASP A 1 234 ? 167.65300 322.50900 28.03000  1.000 63.87001  ? 269 ASP F CA  1 
ATOM   1566 C C   . ASP A 1 234 ? 168.40200 323.29400 26.98200  1.000 61.26543  ? 269 ASP F C   1 
ATOM   1567 O O   . ASP A 1 234 ? 167.86700 324.28300 26.47500  1.000 62.41323  ? 269 ASP F O   1 
ATOM   1568 C CB  . ASP A 1 234 ? 167.86200 323.11300 29.42500  1.000 73.89018  ? 269 ASP F CB  1 
ATOM   1569 C CG  . ASP A 1 234 ? 166.99800 322.43600 30.49100  1.000 80.14417  ? 269 ASP F CG  1 
ATOM   1570 O OD1 . ASP A 1 234 ? 165.89600 321.94200 30.12900  1.000 77.96837  ? 269 ASP F OD1 1 
ATOM   1571 O OD2 . ASP A 1 234 ? 167.38200 322.46800 31.68600  1.000 83.27646  ? 269 ASP F OD2 1 
ATOM   1572 N N   . GLN A 1 235 ? 169.52700 322.78700 26.51000  1.000 59.64358  ? 270 GLN F N   1 
ATOM   1573 C CA  . GLN A 1 235 ? 170.23000 323.54200 25.49200  1.000 60.86383  ? 270 GLN F CA  1 
ATOM   1574 C C   . GLN A 1 235 ? 169.59500 323.27800 24.14600  1.000 58.16718  ? 270 GLN F C   1 
ATOM   1575 O O   . GLN A 1 235 ? 169.55700 324.17500 23.29200  1.000 57.25931  ? 270 GLN F O   1 
ATOM   1576 C CB  . GLN A 1 235 ? 171.70600 323.16300 25.47400  1.000 60.46665  ? 270 GLN F CB  1 
ATOM   1577 C CG  . GLN A 1 235 ? 172.51300 324.08500 24.59500  1.000 70.35853  ? 270 GLN F CG  1 
ATOM   1578 C CD  . GLN A 1 235 ? 173.68600 324.71500 25.30000  1.000 67.16554  ? 270 GLN F CD  1 
ATOM   1579 O OE1 . GLN A 1 235 ? 173.85600 324.55900 26.51300  1.000 65.30512  ? 270 GLN F OE1 1 
ATOM   1580 N NE2 . GLN A 1 235 ? 174.54900 325.38700 24.52100  1.000 62.28697  ? 270 GLN F NE2 1 
ATOM   1581 N N   . LYS A 1 236 ? 169.02800 322.08400 23.96200  1.000 61.13208  ? 271 LYS F N   1 
ATOM   1582 C CA  . LYS A 1 236 ? 168.31900 321.85600 22.71800  1.000 60.36784  ? 271 LYS F CA  1 
ATOM   1583 C C   . LYS A 1 236 ? 167.05400 322.70400 22.68900  1.000 54.57716  ? 271 LYS F C   1 
ATOM   1584 O O   . LYS A 1 236 ? 166.75900 323.34000 21.67500  1.000 54.14662  ? 271 LYS F O   1 
ATOM   1585 C CB  . LYS A 1 236 ? 167.96100 320.36700 22.59000  1.000 58.81180  ? 271 LYS F CB  1 
ATOM   1586 C CG  . LYS A 1 236 ? 169.14200 319.41000 22.48500  1.000 62.86496  ? 271 LYS F CG  1 
ATOM   1587 C CD  . LYS A 1 236 ? 168.68400 317.94800 22.40100  1.000 65.55225  ? 271 LYS F CD  1 
ATOM   1588 C CE  . LYS A 1 236 ? 169.87800 317.00200 22.33400  1.000 67.04193  ? 271 LYS F CE  1 
ATOM   1589 N NZ  . LYS A 1 236 ? 169.51300 315.56000 22.27600  1.000 71.51683  ? 271 LYS F NZ  1 
ATOM   1590 N N   . LYS A 1 237 ? 166.36000 322.82200 23.82800  1.000 56.16426  ? 272 LYS F N   1 
ATOM   1591 C CA  . LYS A 1 237 ? 165.18300 323.69300 23.88400  1.000 61.81557  ? 272 LYS F CA  1 
ATOM   1592 C C   . LYS A 1 237 ? 165.54100 325.16300 23.70800  1.000 55.61492  ? 272 LYS F C   1 
ATOM   1593 O O   . LYS A 1 237 ? 164.81000 325.90900 23.03800  1.000 55.56431  ? 272 LYS F O   1 
ATOM   1594 C CB  . LYS A 1 237 ? 164.45000 323.51600 25.22300  1.000 60.45124  ? 272 LYS F CB  1 
ATOM   1595 C CG  . LYS A 1 237 ? 163.00100 324.01900 25.22100  1.000 69.22304  ? 272 LYS F CG  1 
ATOM   1596 C CD  . LYS A 1 237 ? 162.03000 322.82500 25.13800  1.000 77.49244  ? 272 LYS F CD  1 
ATOM   1597 C CE  . LYS A 1 237 ? 160.79200 323.08700 24.26300  1.000 78.93960  ? 272 LYS F CE  1 
ATOM   1598 N NZ  . LYS A 1 237 ? 161.13400 323.22300 22.80600  1.000 73.65115  ? 272 LYS F NZ  1 
ATOM   1599 N N   . LEU A 1 238 ? 166.72400 325.56200 24.17400  1.000 55.98309  ? 273 LEU F N   1 
ATOM   1600 C CA  . LEU A 1 238 ? 167.11000 326.96200 24.05000  1.000 54.46135  ? 273 LEU F CA  1 
ATOM   1601 C C   . LEU A 1 238 ? 167.41600 327.28900 22.60400  1.000 44.10928  ? 273 LEU F C   1 
ATOM   1602 O O   . LEU A 1 238 ? 166.88700 328.25600 22.05600  1.000 46.62483  ? 273 LEU F O   1 
ATOM   1603 C CB  . LEU A 1 238 ? 168.32000 327.26200 24.92900  1.000 52.04979  ? 273 LEU F CB  1 
ATOM   1604 C CG  . LEU A 1 238 ? 168.74600 328.73600 24.97000  1.000 54.68934  ? 273 LEU F CG  1 
ATOM   1605 C CD1 . LEU A 1 238 ? 167.66500 329.64300 25.55300  1.000 52.90312  ? 273 LEU F CD1 1 
ATOM   1606 C CD2 . LEU A 1 238 ? 170.06300 328.88600 25.72900  1.000 52.12659  ? 273 LEU F CD2 1 
ATOM   1607 N N   . MET A 1 239 ? 168.22000 326.45300 21.95200  1.000 43.49606  ? 274 MET F N   1 
ATOM   1608 C CA  . MET A 1 239 ? 168.54600 326.75400 20.57100  1.000 44.42132  ? 274 MET F CA  1 
ATOM   1609 C C   . MET A 1 239 ? 167.32400 326.58700 19.66700  1.000 52.59821  ? 274 MET F C   1 
ATOM   1610 O O   . MET A 1 239 ? 167.18600 327.33000 18.69300  1.000 51.44308  ? 274 MET F O   1 
ATOM   1611 C CB  . MET A 1 239 ? 169.69800 325.87900 20.09700  1.000 49.48578  ? 274 MET F CB  1 
ATOM   1612 C CG  . MET A 1 239 ? 170.96300 326.03500 20.93300  1.000 45.53102  ? 274 MET F CG  1 
ATOM   1613 S SD  . MET A 1 239 ? 172.25700 324.97200 20.31500  1.000 46.91040  ? 274 MET F SD  1 
ATOM   1614 C CE  . MET A 1 239 ? 172.58300 325.65400 18.69000  1.000 48.75258  ? 274 MET F CE  1 
ATOM   1615 N N   . SER A 1 240 ? 166.38700 325.68400 20.00800  1.000 51.78913  ? 275 SER F N   1 
ATOM   1616 C CA  . SER A 1 240 ? 165.20400 325.47900 19.16900  1.000 51.09391  ? 275 SER F CA  1 
ATOM   1617 C C   . SER A 1 240 ? 164.20900 326.61200 19.31500  1.000 52.02305  ? 275 SER F C   1 
ATOM   1618 O O   . SER A 1 240 ? 163.51700 326.94400 18.35400  1.000 59.00491  ? 275 SER F O   1 
ATOM   1619 C CB  . SER A 1 240 ? 164.51100 324.17400 19.52700  1.000 49.34509  ? 275 SER F CB  1 
ATOM   1620 O OG  . SER A 1 240 ? 165.39500 323.10800 19.33100  1.000 53.58991  ? 275 SER F OG  1 
ATOM   1621 N N   . ASN A 1 241 ? 164.18600 327.27600 20.46700  1.000 53.22735  ? 276 ASN F N   1 
ATOM   1622 C CA  . ASN A 1 241 ? 163.30200 328.41500 20.64800  1.000 51.07660  ? 276 ASN F CA  1 
ATOM   1623 C C   . ASN A 1 241 ? 163.89900 329.72600 20.14000  1.000 54.14142  ? 276 ASN F C   1 
ATOM   1624 O O   . ASN A 1 241 ? 163.19500 330.74200 20.11400  1.000 53.82640  ? 276 ASN F O   1 
ATOM   1625 C CB  . ASN A 1 241 ? 162.90400 328.53900 22.12300  1.000 53.80652  ? 276 ASN F CB  1 
ATOM   1626 C CG  . ASN A 1 241 ? 162.01900 327.37700 22.59800  1.000 64.07386  ? 276 ASN F CG  1 
ATOM   1627 O OD1 . ASN A 1 241 ? 161.98400 326.30500 21.99100  1.000 64.14399  ? 276 ASN F OD1 1 
ATOM   1628 N ND2 . ASN A 1 241 ? 161.32600 327.58500 23.71100  1.000 65.35730  ? 276 ASN F ND2 1 
ATOM   1629 N N   . ASN A 1 242 ? 165.17600 329.74900 19.77800  1.000 49.92447  ? 277 ASN F N   1 
ATOM   1630 C CA  . ASN A 1 242 ? 165.80800 330.95600 19.24100  1.000 48.35834  ? 277 ASN F CA  1 
ATOM   1631 C C   . ASN A 1 242 ? 166.57900 330.62100 17.99800  1.000 47.99768  ? 277 ASN F C   1 
ATOM   1632 O O   . ASN A 1 242 ? 167.73500 331.02800 17.82500  1.000 45.98949  ? 277 ASN F O   1 
ATOM   1633 C CB  . ASN A 1 242 ? 166.73000 331.59000 20.26900  1.000 42.80314  ? 277 ASN F CB  1 
ATOM   1634 C CG  . ASN A 1 242 ? 166.02400 331.90400 21.53900  1.000 44.67528  ? 277 ASN F CG  1 
ATOM   1635 O OD1 . ASN A 1 242 ? 165.43000 332.96600 21.66900  1.000 53.22461  ? 277 ASN F OD1 1 
ATOM   1636 N ND2 . ASN A 1 242 ? 166.05300 330.97700 22.48600  1.000 50.58490  ? 277 ASN F ND2 1 
ATOM   1637 N N   . VAL A 1 243 ? 165.89800 329.98000 17.04700  1.000 48.57299  ? 278 VAL F N   1 
ATOM   1638 C CA  . VAL A 1 243 ? 166.59000 329.52500 15.84200  1.000 51.89591  ? 278 VAL F CA  1 
ATOM   1639 C C   . VAL A 1 243 ? 167.07600 330.68500 15.01200  1.000 45.61171  ? 278 VAL F C   1 
ATOM   1640 O O   . VAL A 1 243 ? 168.04600 330.54700 14.26100  1.000 50.56889  ? 278 VAL F O   1 
ATOM   1641 C CB  . VAL A 1 243 ? 165.68900 328.61200 14.98200  1.000 51.88929  ? 278 VAL F CB  1 
ATOM   1642 C CG1 . VAL A 1 243 ? 165.39300 327.34500 15.70600  1.000 55.65546  ? 278 VAL F CG1 1 
ATOM   1643 C CG2 . VAL A 1 243 ? 164.39900 329.33500 14.66400  1.000 54.61205  ? 278 VAL F CG2 1 
ATOM   1644 N N   . GLN A 1 244 ? 166.36800 331.80200 15.03000  1.000 48.41446  ? 279 GLN F N   1 
ATOM   1645 C CA  . GLN A 1 244 ? 166.85000 332.90400 14.21600  1.000 56.79622  ? 279 GLN F CA  1 
ATOM   1646 C C   . GLN A 1 244 ? 168.14000 333.49500 14.78900  1.000 51.46075  ? 279 GLN F C   1 
ATOM   1647 O O   . GLN A 1 244 ? 169.08200 333.80500 14.04400  1.000 48.44300  ? 279 GLN F O   1 
ATOM   1648 C CB  . GLN A 1 244 ? 165.73300 333.91600 14.03600  1.000 57.59420  ? 279 GLN F CB  1 
ATOM   1649 C CG  . GLN A 1 244 ? 164.63100 333.18900 13.22000  1.000 67.95815  ? 279 GLN F CG  1 
ATOM   1650 C CD  . GLN A 1 244 ? 165.10600 332.62000 11.84700  1.000 68.72926  ? 279 GLN F CD  1 
ATOM   1651 O OE1 . GLN A 1 244 ? 165.94400 333.20700 11.14200  1.000 66.37405  ? 279 GLN F OE1 1 
ATOM   1652 N NE2 . GLN A 1 244 ? 164.58900 331.42700 11.50300  1.000 69.47439  ? 279 GLN F NE2 1 
ATOM   1653 N N   . ILE A 1 245 ? 168.23900 333.57700 16.11500  1.000 50.36964  ? 280 ILE F N   1 
ATOM   1654 C CA  . ILE A 1 245 ? 169.49100 334.03200 16.70600  1.000 44.77344  ? 280 ILE F CA  1 
ATOM   1655 C C   . ILE A 1 245 ? 170.58400 333.01100 16.44500  1.000 42.65252  ? 280 ILE F C   1 
ATOM   1656 O O   . ILE A 1 245 ? 171.71500 333.36900 16.09300  1.000 42.35381  ? 280 ILE F O   1 
ATOM   1657 C CB  . ILE A 1 245 ? 169.30500 334.28700 18.20600  1.000 47.36073  ? 280 ILE F CB  1 
ATOM   1658 C CG1 . ILE A 1 245 ? 168.35400 335.45100 18.40800  1.000 41.10678  ? 280 ILE F CG1 1 
ATOM   1659 C CG2 . ILE A 1 245 ? 170.63000 334.66700 18.81200  1.000 44.67956  ? 280 ILE F CG2 1 
ATOM   1660 C CD1 . ILE A 1 245 ? 168.15300 335.82100 19.84000  1.000 44.11336  ? 280 ILE F CD1 1 
ATOM   1661 N N   . VAL A 1 246 ? 170.23800 331.72300 16.47700  1.000 39.29466  ? 281 VAL F N   1 
ATOM   1662 C CA  . VAL A 1 246 ? 171.23400 330.70400 16.17100  1.000 41.77880  ? 281 VAL F CA  1 
ATOM   1663 C C   . VAL A 1 246 ? 171.73100 330.86800 14.74400  1.000 44.03578  ? 281 VAL F C   1 
ATOM   1664 O O   . VAL A 1 246 ? 172.93300 330.71300 14.46500  1.000 44.48034  ? 281 VAL F O   1 
ATOM   1665 C CB  . VAL A 1 246 ? 170.67300 329.28300 16.42000  1.000 40.57089  ? 281 VAL F CB  1 
ATOM   1666 C CG1 . VAL A 1 246 ? 171.62200 328.21700 15.87900  1.000 35.80350  ? 281 VAL F CG1 1 
ATOM   1667 C CG2 . VAL A 1 246 ? 170.41500 329.05500 17.87200  1.000 43.41143  ? 281 VAL F CG2 1 
ATOM   1668 N N   . ARG A 1 247 ? 170.81900 331.14100 13.80500  1.000 45.71999  ? 282 ARG F N   1 
ATOM   1669 C CA  . ARG A 1 247 ? 171.26000 331.35100 12.42100  1.000 48.11892  ? 282 ARG F CA  1 
ATOM   1670 C C   . ARG A 1 247 ? 172.17500 332.55300 12.31100  1.000 41.11587  ? 282 ARG F C   1 
ATOM   1671 O O   . ARG A 1 247 ? 173.19500 332.49800 11.61500  1.000 43.47199  ? 282 ARG F O   1 
ATOM   1672 C CB  . ARG A 1 247 ? 170.08400 331.52200 11.44900  1.000 50.55369  ? 282 ARG F CB  1 
ATOM   1673 C CG  . ARG A 1 247 ? 169.22700 330.28900 11.23300  1.000 57.95044  ? 282 ARG F CG  1 
ATOM   1674 C CD  . ARG A 1 247 ? 168.10400 330.52800 10.19000  1.000 61.22471  ? 282 ARG F CD  1 
ATOM   1675 N NE  . ARG A 1 247 ? 167.37700 329.28500 9.96500   1.000 58.06337  ? 282 ARG F NE  1 
ATOM   1676 C CZ  . ARG A 1 247 ? 167.77800 328.35900 9.10400   1.000 58.49959  ? 282 ARG F CZ  1 
ATOM   1677 N NH1 . ARG A 1 247 ? 168.87700 328.51500 8.39100   1.000 52.41617  ? 282 ARG F NH1 1 
ATOM   1678 N NH2 . ARG A 1 247 ? 167.09000 327.22300 8.99700   1.000 63.87867  ? 282 ARG F NH2 1 
ATOM   1679 N N   . GLN A 1 248 ? 171.83400 333.64600 12.99800  1.000 40.16915  ? 283 GLN F N   1 
ATOM   1680 C CA  . GLN A 1 248 ? 172.66600 334.84400 12.92100  1.000 47.45354  ? 283 GLN F CA  1 
ATOM   1681 C C   . GLN A 1 248 ? 174.03600 334.65100 13.56600  1.000 49.13247  ? 283 GLN F C   1 
ATOM   1682 O O   . GLN A 1 248 ? 174.97200 335.38200 13.23600  1.000 54.03811  ? 283 GLN F O   1 
ATOM   1683 C CB  . GLN A 1 248 ? 171.95000 336.03900 13.55600  1.000 49.79329  ? 283 GLN F CB  1 
ATOM   1684 C CG  . GLN A 1 248 ? 170.67800 336.49200 12.79800  1.000 55.37275  ? 283 GLN F CG  1 
ATOM   1685 C CD  . GLN A 1 248 ? 169.89400 337.56500 13.54100  1.000 61.42681  ? 283 GLN F CD  1 
ATOM   1686 O OE1 . GLN A 1 248 ? 170.19400 337.86900 14.69200  1.000 63.75092  ? 283 GLN F OE1 1 
ATOM   1687 N NE2 . GLN A 1 248 ? 168.92300 338.18700 12.86100  1.000 63.92864  ? 283 GLN F NE2 1 
ATOM   1688 N N   . GLN A 1 249 ? 174.20300 333.64900 14.41900  1.000 50.18661  ? 284 GLN F N   1 
ATOM   1689 C CA  . GLN A 1 249 ? 175.49800 333.38700 15.02700  1.000 48.46138  ? 284 GLN F CA  1 
ATOM   1690 C C   . GLN A 1 249 ? 176.12000 332.10600 14.50800  1.000 49.80602  ? 284 GLN F C   1 
ATOM   1691 O O   . GLN A 1 249 ? 177.01700 331.55100 15.14300  1.000 51.09663  ? 284 GLN F O   1 
ATOM   1692 C CB  . GLN A 1 249 ? 175.30500 333.34400 16.54200  1.000 41.20030  ? 284 GLN F CB  1 
ATOM   1693 C CG  . GLN A 1 249 ? 174.92500 334.70800 17.05000  1.000 39.23402  ? 284 GLN F CG  1 
ATOM   1694 C CD  . GLN A 1 249 ? 174.80900 334.81400 18.54800  1.000 45.91006  ? 284 GLN F CD  1 
ATOM   1695 O OE1 . GLN A 1 249 ? 174.73800 333.81200 19.25800  1.000 44.56127  ? 284 GLN F OE1 1 
ATOM   1696 N NE2 . GLN A 1 249 ? 174.79200 336.04500 19.04200  1.000 46.62207  ? 284 GLN F NE2 1 
ATOM   1697 N N   . SER A 1 250 ? 175.78300 331.72500 13.27700  1.000 46.82528  ? 285 SER F N   1 
ATOM   1698 C CA  . SER A 1 250 ? 176.33200 330.52400 12.67100  1.000 41.24122  ? 285 SER F CA  1 
ATOM   1699 C C   . SER A 1 250 ? 177.01900 330.90700 11.37000  1.000 44.50818  ? 285 SER F C   1 
ATOM   1700 O O   . SER A 1 250 ? 176.74300 331.96300 10.79400  1.000 45.62524  ? 285 SER F O   1 
ATOM   1701 C CB  . SER A 1 250 ? 175.22600 329.49600 12.39200  1.000 44.96832  ? 285 SER F CB  1 
ATOM   1702 O OG  . SER A 1 250 ? 174.58700 329.11100 13.60300  1.000 43.12280  ? 285 SER F OG  1 
ATOM   1703 N N   . TYR A 1 251 ? 177.83100 329.98600 10.86100  1.000 40.73257  ? 286 TYR F N   1 
ATOM   1704 C CA  . TYR A 1 251 ? 178.55100 330.14500 9.61500   1.000 42.70311  ? 286 TYR F CA  1 
ATOM   1705 C C   . TYR A 1 251 ? 178.32900 328.93300 8.72400   1.000 53.75981  ? 286 TYR F C   1 
ATOM   1706 O O   . TYR A 1 251 ? 178.09800 327.82100 9.21100   1.000 52.50799  ? 286 TYR F O   1 
ATOM   1707 C CB  . TYR A 1 251 ? 180.06300 330.25900 9.82900   1.000 46.77244  ? 286 TYR F CB  1 
ATOM   1708 C CG  . TYR A 1 251 ? 180.52900 331.57600 10.38600  1.000 52.15687  ? 286 TYR F CG  1 
ATOM   1709 C CD1 . TYR A 1 251 ? 180.45600 331.83400 11.75500  1.000 47.02184  ? 286 TYR F CD1 1 
ATOM   1710 C CD2 . TYR A 1 251 ? 181.06300 332.55500 9.56000   1.000 50.91349  ? 286 TYR F CD2 1 
ATOM   1711 C CE1 . TYR A 1 251 ? 180.89100 333.04200 12.28400  1.000 49.89846  ? 286 TYR F CE1 1 
ATOM   1712 C CE2 . TYR A 1 251 ? 181.49700 333.76000 10.07700  1.000 47.36580  ? 286 TYR F CE2 1 
ATOM   1713 C CZ  . TYR A 1 251 ? 181.41300 333.99400 11.43900  1.000 49.84212  ? 286 TYR F CZ  1 
ATOM   1714 O OH  . TYR A 1 251 ? 181.83800 335.18500 11.95300  1.000 51.86258  ? 286 TYR F OH  1 
ATOM   1715 N N   . SER A 1 252 ? 178.29500 329.18300 7.41700   1.000 51.15482  ? 287 SER F N   1 
ATOM   1716 C CA  . SER A 1 252 ? 178.25900 328.15400 6.38400   1.000 49.46412  ? 287 SER F CA  1 
ATOM   1717 C C   . SER A 1 252 ? 179.49300 328.31600 5.49900   1.000 48.47058  ? 287 SER F C   1 
ATOM   1718 O O   . SER A 1 252 ? 179.70700 329.38600 4.92500   1.000 55.68372  ? 287 SER F O   1 
ATOM   1719 C CB  . SER A 1 252 ? 176.96000 328.22500 5.57300   1.000 60.12622  ? 287 SER F CB  1 
ATOM   1720 O OG  . SER A 1 252 ? 176.89400 327.16600 4.63000   1.000 58.92342  ? 287 SER F OG  1 
ATOM   1721 N N   . ILE A 1 253 ? 180.34900 327.30000 5.45800   1.000 53.30435  ? 288 ILE F N   1 
ATOM   1722 C CA  . ILE A 1 253 ? 181.62900 327.33800 4.75500   1.000 48.06082  ? 288 ILE F CA  1 
ATOM   1723 C C   . ILE A 1 253 ? 181.61900 326.32500 3.61900   1.000 58.83907  ? 288 ILE F C   1 
ATOM   1724 O O   . ILE A 1 253 ? 181.35600 325.13700 3.84300   1.000 58.57609  ? 288 ILE F O   1 
ATOM   1725 C CB  . ILE A 1 253 ? 182.82500 327.08700 5.69700   1.000 48.19549  ? 288 ILE F CB  1 
ATOM   1726 C CG1 . ILE A 1 253 ? 182.71800 327.96300 6.95600   1.000 54.24786  ? 288 ILE F CG1 1 
ATOM   1727 C CG2 . ILE A 1 253 ? 184.12700 327.22200 4.95300   1.000 45.37294  ? 288 ILE F CG2 1 
ATOM   1728 C CD1 . ILE A 1 253 ? 182.32200 327.25500 8.22500   1.000 52.18411  ? 288 ILE F CD1 1 
ATOM   1729 N N   . MET A 1 254 ? 181.98900 326.76900 2.41900   1.000 58.00624  ? 289 MET F N   1 
ATOM   1730 C CA  . MET A 1 254 ? 182.01100 325.83900 1.30800   1.000 60.79092  ? 289 MET F CA  1 
ATOM   1731 C C   . MET A 1 254 ? 183.30700 325.05700 1.37400   1.000 63.76845  ? 289 MET F C   1 
ATOM   1732 O O   . MET A 1 254 ? 184.39900 325.63500 1.41800   1.000 61.66795  ? 289 MET F O   1 
ATOM   1733 C CB  . MET A 1 254 ? 181.92400 326.57000 -0.04000  1.000 55.65280  ? 289 MET F CB  1 
ATOM   1734 C CG  . MET A 1 254 ? 180.99500 325.90500 -1.06200  1.000 66.57148  ? 289 MET F CG  1 
ATOM   1735 S SD  . MET A 1 254 ? 181.66400 324.46800 -1.96800  1.000 77.59829  ? 289 MET F SD  1 
ATOM   1736 C CE  . MET A 1 254 ? 183.19400 325.11500 -2.68900  1.000 77.65344  ? 289 MET F CE  1 
ATOM   1737 N N   . CYS A 1 255 ? 183.16600 323.73600 1.30900   1.000 63.85278  ? 290 CYS F N   1 
ATOM   1738 C CA  . CYS A 1 255 ? 184.22700 322.73500 1.36400   1.000 64.13396  ? 290 CYS F CA  1 
ATOM   1739 C C   . CYS A 1 255 ? 184.61100 322.36600 -0.05500  1.000 71.94210  ? 290 CYS F C   1 
ATOM   1740 O O   . CYS A 1 255 ? 185.44400 323.03900 -0.67700  1.000 71.11024  ? 290 CYS F O   1 
ATOM   1741 C CB  . CYS A 1 255 ? 183.84100 321.51200 2.19500   1.000 66.16654  ? 290 CYS F CB  1 
ATOM   1742 S SG  . CYS A 1 255 ? 183.88200 321.76000 4.01500   1.000 84.23382  ? 290 CYS F SG  1 
ATOM   1743 N N   . ILE A 1 256 ? 184.11400 321.23200 -0.54000  1.000 70.86793  ? 291 ILE F N   1 
ATOM   1744 C CA  . ILE A 1 256 ? 184.59800 320.76400 -1.82700  1.000 74.13494  ? 291 ILE F CA  1 
ATOM   1745 C C   . ILE A 1 256 ? 183.45600 320.20400 -2.66700  1.000 70.56988  ? 291 ILE F C   1 
ATOM   1746 O O   . ILE A 1 256 ? 182.43100 319.74200 -2.14800  1.000 63.17904  ? 291 ILE F O   1 
ATOM   1747 C CB  . ILE A 1 256 ? 185.65800 319.66800 -1.51200  1.000 73.24422  ? 291 ILE F CB  1 
ATOM   1748 C CG1 . ILE A 1 256 ? 186.53600 319.29500 -2.70100  1.000 81.84607  ? 291 ILE F CG1 1 
ATOM   1749 C CG2 . ILE A 1 256 ? 184.97900 318.42100 -0.92800  1.000 69.78345  ? 291 ILE F CG2 1 
ATOM   1750 C CD1 . ILE A 1 256 ? 187.56600 318.20300 -2.34100  1.000 83.56957  ? 291 ILE F CD1 1 
ATOM   1751 N N   . ILE A 1 257 ? 183.62000 320.29300 -3.98700  1.000 73.35274  ? 292 ILE F N   1 
ATOM   1752 C CA  . ILE A 1 257 ? 182.73700 319.60700 -4.91800  1.000 73.79376  ? 292 ILE F CA  1 
ATOM   1753 C C   . ILE A 1 257 ? 183.61400 318.54600 -5.56800  1.000 72.00937  ? 292 ILE F C   1 
ATOM   1754 O O   . ILE A 1 257 ? 184.48600 318.86800 -6.38500  1.000 70.25914  ? 292 ILE F O   1 
ATOM   1755 C CB  . ILE A 1 257 ? 182.13100 320.59800 -5.92200  1.000 70.76489  ? 292 ILE F CB  1 
ATOM   1756 C CG1 . ILE A 1 257 ? 181.14300 319.92500 -6.86100  1.000 69.23849  ? 292 ILE F CG1 1 
ATOM   1757 C CG2 . ILE A 1 257 ? 183.23100 321.33700 -6.69600  1.000 70.70333  ? 292 ILE F CG2 1 
ATOM   1758 C CD1 . ILE A 1 257 ? 180.65800 320.86900 -7.93900  1.000 70.67167  ? 292 ILE F CD1 1 
ATOM   1759 N N   . LYS A 1 258 ? 183.34300 317.27700 -5.29100  1.000 72.68837  ? 293 LYS F N   1 
ATOM   1760 C CA  . LYS A 1 258 ? 184.25300 316.25700 -5.79500  1.000 77.23114  ? 293 LYS F CA  1 
ATOM   1761 C C   . LYS A 1 258 ? 183.54300 314.91300 -5.84900  1.000 77.69146  ? 293 LYS F C   1 
ATOM   1762 O O   . LYS A 1 258 ? 182.85700 314.54400 -4.88500  1.000 73.46381  ? 293 LYS F O   1 
ATOM   1763 C CB  . LYS A 1 258 ? 185.53200 316.18500 -4.94600  1.000 76.38200  ? 293 LYS F CB  1 
ATOM   1764 C CG  . LYS A 1 258 ? 186.50600 315.11500 -5.40900  1.000 81.71671  ? 293 LYS F CG  1 
ATOM   1765 C CD  . LYS A 1 258 ? 187.80500 315.05800 -4.59000  1.000 82.32893  ? 293 LYS F CD  1 
ATOM   1766 C CE  . LYS A 1 258 ? 187.53800 314.82100 -3.10900  1.000 85.70616  ? 293 LYS F CE  1 
ATOM   1767 N NZ  . LYS A 1 258 ? 188.79600 314.81900 -2.31500  1.000 83.51766  ? 293 LYS F NZ  1 
ATOM   1768 N N   . GLU A 1 259 ? 183.64400 314.22000 -6.98200  1.000 79.69842  ? 294 GLU F N   1 
ATOM   1769 C CA  . GLU A 1 259 ? 183.10900 312.86500 -7.09200  1.000 76.16880  ? 294 GLU F CA  1 
ATOM   1770 C C   . GLU A 1 259 ? 181.61900 312.81200 -6.75600  1.000 75.69529  ? 294 GLU F C   1 
ATOM   1771 O O   . GLU A 1 259 ? 181.17500 312.09300 -5.85500  1.000 75.55930  ? 294 GLU F O   1 
ATOM   1772 C CB  . GLU A 1 259 ? 183.89800 311.97400 -6.12700  1.000 81.22454  ? 294 GLU F CB  1 
ATOM   1773 C CG  . GLU A 1 259 ? 185.38100 311.85500 -6.46500  1.000 80.68910  ? 294 GLU F CG  1 
ATOM   1774 C CD  . GLU A 1 259 ? 186.13800 311.02700 -5.44200  1.000 87.74041  ? 294 GLU F CD  1 
ATOM   1775 O OE1 . GLU A 1 259 ? 185.50700 310.57900 -4.46100  1.000 85.77447  ? 294 GLU F OE1 1 
ATOM   1776 O OE2 . GLU A 1 259 ? 187.37000 310.86400 -5.59600  1.000 89.84142  ? 294 GLU F OE2 1 
ATOM   1777 N N   . GLU A 1 260 ? 180.85600 313.62800 -7.47700  1.000 75.02846  ? 295 GLU F N   1 
ATOM   1778 C CA  . GLU A 1 260 ? 179.39300 313.62800 -7.41100  1.000 79.75015  ? 295 GLU F CA  1 
ATOM   1779 C C   . GLU A 1 260 ? 178.90200 313.93100 -6.00100  1.000 73.51200  ? 295 GLU F C   1 
ATOM   1780 O O   . GLU A 1 260 ? 177.83300 313.46500 -5.59200  1.000 74.88806  ? 295 GLU F O   1 
ATOM   1781 C CB  . GLU A 1 260 ? 178.78800 312.29800 -7.88000  1.000 83.19241  ? 295 GLU F CB  1 
ATOM   1782 C CG  . GLU A 1 260 ? 179.39400 311.65800 -9.12200  1.000 86.21004  ? 295 GLU F CG  1 
ATOM   1783 C CD  . GLU A 1 260 ? 178.66900 310.35700 -9.49100  1.000 89.99183  ? 295 GLU F CD  1 
ATOM   1784 O OE1 . GLU A 1 260 ? 178.57000 309.44400 -8.63000  1.000 85.88272  ? 295 GLU F OE1 1 
ATOM   1785 O OE2 . GLU A 1 260 ? 178.17900 310.26000 -10.63700 1.000 91.95844  ? 295 GLU F OE2 1 
ATOM   1786 N N   . VAL A 1 261 ? 179.65400 314.74100 -5.26300  1.000 74.29696  ? 296 VAL F N   1 
ATOM   1787 C CA  . VAL A 1 261 ? 179.29700 315.10300 -3.90000  1.000 70.11268  ? 296 VAL F CA  1 
ATOM   1788 C C   . VAL A 1 261 ? 179.59900 316.58400 -3.71700  1.000 68.43806  ? 296 VAL F C   1 
ATOM   1789 O O   . VAL A 1 261 ? 180.70100 317.04600 -4.04200  1.000 66.52336  ? 296 VAL F O   1 
ATOM   1790 C CB  . VAL A 1 261 ? 180.05500 314.24900 -2.86600  1.000 76.58098  ? 296 VAL F CB  1 
ATOM   1791 C CG1 . VAL A 1 261 ? 179.78100 314.75700 -1.46400  1.000 75.25777  ? 296 VAL F CG1 1 
ATOM   1792 C CG2 . VAL A 1 261 ? 179.69300 312.76100 -3.01300  1.000 81.78923  ? 296 VAL F CG2 1 
ATOM   1793 N N   . LEU A 1 262 ? 178.62500 317.34400 -3.24600  1.000 65.14340  ? 297 LEU F N   1 
ATOM   1794 C CA  . LEU A 1 262 ? 178.86500 318.73200 -2.87400  1.000 68.20837  ? 297 LEU F CA  1 
ATOM   1795 C C   . LEU A 1 262 ? 178.80700 318.82000 -1.35300  1.000 66.10667  ? 297 LEU F C   1 
ATOM   1796 O O   . LEU A 1 262 ? 177.77000 318.49900 -0.76600  1.000 66.22355  ? 297 LEU F O   1 
ATOM   1797 C CB  . LEU A 1 262 ? 177.84400 319.68400 -3.49500  1.000 65.47806  ? 297 LEU F CB  1 
ATOM   1798 C CG  . LEU A 1 262 ? 177.81700 321.04600 -2.78100  1.000 65.00002  ? 297 LEU F CG  1 
ATOM   1799 C CD1 . LEU A 1 262 ? 179.18200 321.74800 -2.94600  1.000 61.41958  ? 297 LEU F CD1 1 
ATOM   1800 C CD2 . LEU A 1 262 ? 176.69500 321.94300 -3.25100  1.000 62.97480  ? 297 LEU F CD2 1 
ATOM   1801 N N   . ALA A 1 263 ? 179.91600 319.19100 -0.70500  1.000 66.57547  ? 298 ALA F N   1 
ATOM   1802 C CA  . ALA A 1 263 ? 179.94100 319.22100 0.75400   1.000 67.69681  ? 298 ALA F CA  1 
ATOM   1803 C C   . ALA A 1 263 ? 180.32400 320.62300 1.21100   1.000 63.07782  ? 298 ALA F C   1 
ATOM   1804 O O   . ALA A 1 263 ? 181.29600 321.20900 0.70100   1.000 60.67497  ? 298 ALA F O   1 
ATOM   1805 C CB  . ALA A 1 263 ? 180.91800 318.19100 1.32800   1.000 68.43256  ? 298 ALA F CB  1 
ATOM   1806 N N   . TYR A 1 264 ? 179.65500 321.06000 2.28800   1.000 62.69948  ? 299 TYR F N   1 
ATOM   1807 C CA  . TYR A 1 264 ? 179.90500 322.33600 2.96100   1.000 64.84122  ? 299 TYR F CA  1 
ATOM   1808 C C   . TYR A 1 264 ? 179.58900 322.21700 4.44900   1.000 61.58216  ? 299 TYR F C   1 
ATOM   1809 O O   . TYR A 1 264 ? 178.75400 321.40500 4.86200   1.000 55.95799  ? 299 TYR F O   1 
ATOM   1810 C CB  . TYR A 1 264 ? 179.07400 323.49600 2.36700   1.000 51.98918  ? 299 TYR F CB  1 
ATOM   1811 C CG  . TYR A 1 264 ? 177.54300 323.37900 2.41400   1.000 56.47238  ? 299 TYR F CG  1 
ATOM   1812 C CD1 . TYR A 1 264 ? 176.82400 323.74500 3.54500   1.000 58.79162  ? 299 TYR F CD1 1 
ATOM   1813 C CD2 . TYR A 1 264 ? 176.80400 322.96700 1.29400   1.000 63.63671  ? 299 TYR F CD2 1 
ATOM   1814 C CE1 . TYR A 1 264 ? 175.40600 323.66900 3.58900   1.000 56.30930  ? 299 TYR F CE1 1 
ATOM   1815 C CE2 . TYR A 1 264 ? 175.37300 322.88300 1.32700   1.000 55.42478  ? 299 TYR F CE2 1 
ATOM   1816 C CZ  . TYR A 1 264 ? 174.68900 323.23400 2.47500   1.000 61.56563  ? 299 TYR F CZ  1 
ATOM   1817 O OH  . TYR A 1 264 ? 173.29900 323.16100 2.52100   1.000 55.66806  ? 299 TYR F OH  1 
ATOM   1818 N N   . VAL A 1 265 ? 180.31100 322.99600 5.26500   1.000 62.83853  ? 300 VAL F N   1 
ATOM   1819 C CA  . VAL A 1 265 ? 180.23000 322.89600 6.72400   1.000 55.74413  ? 300 VAL F CA  1 
ATOM   1820 C C   . VAL A 1 265 ? 179.33800 323.98000 7.29900   1.000 55.34084  ? 300 VAL F C   1 
ATOM   1821 O O   . VAL A 1 265 ? 179.45400 325.15500 6.93500   1.000 59.16367  ? 300 VAL F O   1 
ATOM   1822 C CB  . VAL A 1 265 ? 181.62300 323.00300 7.35600   1.000 66.03343  ? 300 VAL F CB  1 
ATOM   1823 C CG1 . VAL A 1 265 ? 181.47900 323.19000 8.86600   1.000 62.08139  ? 300 VAL F CG1 1 
ATOM   1824 C CG2 . VAL A 1 265 ? 182.46400 321.79500 6.99800   1.000 63.59420  ? 300 VAL F CG2 1 
ATOM   1825 N N   . VAL A 1 266 ? 178.43200 323.58400 8.17700   1.000 52.33781  ? 301 VAL F N   1 
ATOM   1826 C CA  . VAL A 1 266 ? 177.64600 324.50700 8.97600   1.000 50.82427  ? 301 VAL F CA  1 
ATOM   1827 C C   . VAL A 1 266 ? 178.20800 324.51200 10.40300  1.000 61.38060  ? 301 VAL F C   1 
ATOM   1828 O O   . VAL A 1 266 ? 178.35900 323.44800 11.02100  1.000 59.06743  ? 301 VAL F O   1 
ATOM   1829 C CB  . VAL A 1 266 ? 176.14900 324.15900 8.95500   1.000 57.24867  ? 301 VAL F CB  1 
ATOM   1830 C CG1 . VAL A 1 266 ? 175.39200 325.05500 9.91500   1.000 58.85964  ? 301 VAL F CG1 1 
ATOM   1831 C CG2 . VAL A 1 266 ? 175.57900 324.36300 7.54400   1.000 60.64205  ? 301 VAL F CG2 1 
ATOM   1832 N N   . GLN A 1 267 ? 178.57700 325.70500 10.90200  1.000 57.27523  ? 302 GLN F N   1 
ATOM   1833 C CA  . GLN A 1 267 ? 179.18800 325.89600 12.21900  1.000 49.01434  ? 302 GLN F CA  1 
ATOM   1834 C C   . GLN A 1 267 ? 178.14200 326.44900 13.17200  1.000 42.64351  ? 302 GLN F C   1 
ATOM   1835 O O   . GLN A 1 267 ? 177.67500 327.57800 12.98800  1.000 46.04679  ? 302 GLN F O   1 
ATOM   1836 C CB  . GLN A 1 267 ? 180.38100 326.85300 12.26400  1.000 48.24522  ? 302 GLN F CB  1 
ATOM   1837 C CG  . GLN A 1 267 ? 181.73700 326.22000 12.41100  1.000 47.50326  ? 302 GLN F CG  1 
ATOM   1838 C CD  . GLN A 1 267 ? 182.86700 327.24900 12.32900  1.000 48.69214  ? 302 GLN F CD  1 
ATOM   1839 O OE1 . GLN A 1 267 ? 183.98000 326.94700 11.89400  1.000 54.08846  ? 302 GLN F OE1 1 
ATOM   1840 N NE2 . GLN A 1 267 ? 182.60200 328.44300 12.83100  1.000 47.18743  ? 302 GLN F NE2 1 
ATOM   1841 N N   . LEU A 1 268 ? 177.70600 325.66100 14.06600  1.000 43.74231  ? 303 LEU F N   1 
ATOM   1842 C CA  . LEU A 1 268 ? 176.63800 326.14000 14.92400  1.000 46.56854  ? 303 LEU F CA  1 
ATOM   1843 C C   . LEU A 1 268 ? 177.20600 326.53900 16.28400  1.000 46.92736  ? 303 LEU F C   1 
ATOM   1844 O O   . LEU A 1 268 ? 178.20200 325.96800 16.74900  1.000 44.56566  ? 303 LEU F O   1 
ATOM   1845 C CB  . LEU A 1 268 ? 175.57100 325.06500 15.14800  1.000 47.71146  ? 303 LEU F CB  1 
ATOM   1846 C CG  . LEU A 1 268 ? 174.81100 324.46800 13.96400  1.000 51.21012  ? 303 LEU F CG  1 
ATOM   1847 C CD1 . LEU A 1 268 ? 173.44900 323.99700 14.45700  1.000 51.76192  ? 303 LEU F CD1 1 
ATOM   1848 C CD2 . LEU A 1 268 ? 174.66800 325.47700 12.87600  1.000 47.67964  ? 303 LEU F CD2 1 
ATOM   1849 N N   . PRO A 1 269 ? 176.61600 327.52700 16.93800  1.000 43.63417  ? 304 PRO F N   1 
ATOM   1850 C CA  . PRO A 1 269 ? 177.18400 328.01300 18.19500  1.000 43.46202  ? 304 PRO F CA  1 
ATOM   1851 C C   . PRO A 1 269 ? 176.87100 327.05200 19.32700  1.000 43.62674  ? 304 PRO F C   1 
ATOM   1852 O O   . PRO A 1 269 ? 175.81400 326.42200 19.36200  1.000 46.40035  ? 304 PRO F O   1 
ATOM   1853 C CB  . PRO A 1 269 ? 176.49100 329.36600 18.39900  1.000 39.51597  ? 304 PRO F CB  1 
ATOM   1854 C CG  . PRO A 1 269 ? 175.18500 329.19500 17.71900  1.000 44.17311  ? 304 PRO F CG  1 
ATOM   1855 C CD  . PRO A 1 269 ? 175.45300 328.31900 16.52100  1.000 40.51442  ? 304 PRO F CD  1 
ATOM   1856 N N   . LEU A 1 270 ? 177.82300 326.90800 20.23200  1.000 44.85038  ? 305 LEU F N   1 
ATOM   1857 C CA  . LEU A 1 270 ? 177.64500 326.18200 21.48100  1.000 43.97521  ? 305 LEU F CA  1 
ATOM   1858 C C   . LEU A 1 270 ? 177.75500 327.22600 22.58000  1.000 36.77132  ? 305 LEU F C   1 
ATOM   1859 O O   . LEU A 1 270 ? 178.81500 327.85000 22.73600  1.000 41.01510  ? 305 LEU F O   1 
ATOM   1860 C CB  . LEU A 1 270 ? 178.71100 325.09900 21.63400  1.000 47.03988  ? 305 LEU F CB  1 
ATOM   1861 C CG  . LEU A 1 270 ? 178.59500 323.83800 20.79800  1.000 47.47678  ? 305 LEU F CG  1 
ATOM   1862 C CD1 . LEU A 1 270 ? 179.73600 322.92100 21.18200  1.000 49.23300  ? 305 LEU F CD1 1 
ATOM   1863 C CD2 . LEU A 1 270 ? 177.23800 323.15100 21.03300  1.000 48.71500  ? 305 LEU F CD2 1 
ATOM   1864 N N   . TYR A 1 271 ? 176.70400 327.36300 23.37200  1.000 36.51892  ? 306 TYR F N   1 
ATOM   1865 C CA  . TYR A 1 271 ? 176.63800 328.38600 24.40800  1.000 36.89457  ? 306 TYR F CA  1 
ATOM   1866 C C   . TYR A 1 271 ? 177.09000 327.75700 25.71400  1.000 39.29587  ? 306 TYR F C   1 
ATOM   1867 O O   . TYR A 1 271 ? 176.29800 327.17800 26.46300  1.000 37.76590  ? 306 TYR F O   1 
ATOM   1868 C CB  . TYR A 1 271 ? 175.22300 328.93500 24.51500  1.000 39.14380  ? 306 TYR F CB  1 
ATOM   1869 C CG  . TYR A 1 271 ? 174.75900 329.58300 23.23500  1.000 43.40591  ? 306 TYR F CG  1 
ATOM   1870 C CD1 . TYR A 1 271 ? 175.14400 330.87800 22.92800  1.000 41.60845  ? 306 TYR F CD1 1 
ATOM   1871 C CD2 . TYR A 1 271 ? 173.91600 328.91300 22.34400  1.000 45.08758  ? 306 TYR F CD2 1 
ATOM   1872 C CE1 . TYR A 1 271 ? 174.74600 331.49900 21.76600  1.000 41.89285  ? 306 TYR F CE1 1 
ATOM   1873 C CE2 . TYR A 1 271 ? 173.48900 329.53300 21.17500  1.000 40.93013  ? 306 TYR F CE2 1 
ATOM   1874 C CZ  . TYR A 1 271 ? 173.90300 330.82900 20.90000  1.000 47.01349  ? 306 TYR F CZ  1 
ATOM   1875 O OH  . TYR A 1 271 ? 173.51400 331.46600 19.75400  1.000 45.75765  ? 306 TYR F OH  1 
ATOM   1876 N N   . GLY A 1 272 ? 178.39800 327.88300 25.96100  1.000 37.07024  ? 307 GLY F N   1 
ATOM   1877 C CA  . GLY A 1 272 ? 179.06000 327.41600 27.16000  1.000 32.73533  ? 307 GLY F CA  1 
ATOM   1878 C C   . GLY A 1 272 ? 178.74700 328.19000 28.41700  1.000 36.80036  ? 307 GLY F C   1 
ATOM   1879 O O   . GLY A 1 272 ? 179.15000 327.74800 29.49400  1.000 38.08649  ? 307 GLY F O   1 
ATOM   1880 N N   . VAL A 1 273 ? 178.28100 329.42200 28.30100  1.000 33.21981  ? 308 VAL F N   1 
ATOM   1881 C CA  . VAL A 1 273 ? 177.86700 330.22100 29.45500  1.000 33.63618  ? 308 VAL F CA  1 
ATOM   1882 C C   . VAL A 1 273 ? 176.37100 330.42100 29.38200  1.000 37.29867  ? 308 VAL F C   1 
ATOM   1883 O O   . VAL A 1 273 ? 175.87900 330.97400 28.39100  1.000 39.57063  ? 308 VAL F O   1 
ATOM   1884 C CB  . VAL A 1 273 ? 178.59900 331.55800 29.53700  1.000 30.09177  ? 308 VAL F CB  1 
ATOM   1885 C CG1 . VAL A 1 273 ? 178.39900 332.13200 30.89200  1.000 29.97741  ? 308 VAL F CG1 1 
ATOM   1886 C CG2 . VAL A 1 273 ? 180.09700 331.30400 29.35400  1.000 31.83356  ? 308 VAL F CG2 1 
ATOM   1887 N N   . ILE A 1 274 ? 175.64300 329.90400 30.36700  1.000 38.33366  ? 309 ILE F N   1 
ATOM   1888 C CA  . ILE A 1 274 ? 174.19500 330.01800 30.37000  1.000 37.83124  ? 309 ILE F CA  1 
ATOM   1889 C C   . ILE A 1 274 ? 173.65700 330.48600 31.70900  1.000 37.23539  ? 309 ILE F C   1 
ATOM   1890 O O   . ILE A 1 274 ? 174.13500 330.07100 32.76500  1.000 37.12787  ? 309 ILE F O   1 
ATOM   1891 C CB  . ILE A 1 274 ? 173.52700 328.69400 29.94600  1.000 43.14214  ? 309 ILE F CB  1 
ATOM   1892 C CG1 . ILE A 1 274 ? 174.00900 328.30200 28.56000  1.000 40.51144  ? 309 ILE F CG1 1 
ATOM   1893 C CG2 . ILE A 1 274 ? 172.03700 328.85600 29.92900  1.000 44.55860  ? 309 ILE F CG2 1 
ATOM   1894 C CD1 . ILE A 1 274 ? 173.26500 329.05700 27.46400  1.000 46.11879  ? 309 ILE F CD1 1 
ATOM   1895 N N   . ASP A 1 275 ? 172.67200 331.36300 31.65300  1.000 33.50164  ? 310 ASP F N   1 
ATOM   1896 C CA  . ASP A 1 275 ? 171.94500 331.90200 32.80500  1.000 35.53841  ? 310 ASP F CA  1 
ATOM   1897 C C   . ASP A 1 275 ? 172.79200 332.60900 33.83600  1.000 37.86741  ? 310 ASP F C   1 
ATOM   1898 O O   . ASP A 1 275 ? 172.41700 332.63300 35.00800  1.000 38.12318  ? 310 ASP F O   1 
ATOM   1899 C CB  . ASP A 1 275 ? 171.15500 330.79800 33.52500  1.000 42.63845  ? 310 ASP F CB  1 
ATOM   1900 C CG  . ASP A 1 275 ? 169.85700 330.42800 32.80100  1.000 47.50435  ? 310 ASP F CG  1 
ATOM   1901 O OD1 . ASP A 1 275 ? 169.74500 330.70100 31.59300  1.000 48.77983  ? 310 ASP F OD1 1 
ATOM   1902 O OD2 . ASP A 1 275 ? 168.92000 329.92500 33.45600  1.000 59.75537  ? 310 ASP F OD2 1 
ATOM   1903 N N   . THR A 1 276 ? 173.79000 333.25700 33.44100  1.000 37.56575  ? 311 THR F N   1 
ATOM   1904 C CA  . THR A 1 276 ? 174.56300 334.09100 34.35700  1.000 37.48065  ? 311 THR F CA  1 
ATOM   1905 C C   . THR A 1 276 ? 173.97500 335.48500 34.26300  1.000 36.79275  ? 311 THR F C   1 
ATOM   1906 O O   . THR A 1 276 ? 173.32900 335.81000 33.25300  1.000 37.43639  ? 311 THR F O   1 
ATOM   1907 C CB  . THR A 1 276 ? 176.05800 334.10600 34.09200  1.000 34.95803  ? 311 THR F CB  1 
ATOM   1908 O OG1 . THR A 1 276 ? 176.33600 334.64400 32.80400  1.000 31.69452  ? 311 THR F OG1 1 
ATOM   1909 C CG2 . THR A 1 276 ? 176.61300 332.66600 34.25300  1.000 36.89758  ? 311 THR F CG2 1 
ATOM   1910 N N   . PRO A 1 277 ? 174.01600 336.24300 35.34600  1.000 36.07705  ? 312 PRO F N   1 
ATOM   1911 C CA  . PRO A 1 277 ? 173.48700 337.60800 35.31700  1.000 38.56975  ? 312 PRO F CA  1 
ATOM   1912 C C   . PRO A 1 277 ? 174.20600 338.46900 34.27400  1.000 41.68819  ? 312 PRO F C   1 
ATOM   1913 O O   . PRO A 1 277 ? 175.43800 338.43600 34.14700  1.000 36.74875  ? 312 PRO F O   1 
ATOM   1914 C CB  . PRO A 1 277 ? 173.78900 338.13100 36.73100  1.000 35.21604  ? 312 PRO F CB  1 
ATOM   1915 C CG  . PRO A 1 277 ? 173.92400 336.93500 37.58100  1.000 37.87222  ? 312 PRO F CG  1 
ATOM   1916 C CD  . PRO A 1 277 ? 174.54800 335.88500 36.67300  1.000 38.50664  ? 312 PRO F CD  1 
ATOM   1917 N N   . CYS A 1 278 ? 173.42400 339.27300 33.55200  1.000 35.72964  ? 313 CYS F N   1 
ATOM   1918 C CA  . CYS A 1 278 ? 173.93300 340.17400 32.52200  1.000 37.35246  ? 313 CYS F CA  1 
ATOM   1919 C C   . CYS A 1 278 ? 173.26100 341.52300 32.74800  1.000 37.74045  ? 313 CYS F C   1 
ATOM   1920 O O   . CYS A 1 278 ? 172.16800 341.59800 33.30400  1.000 33.05693  ? 313 CYS F O   1 
ATOM   1921 C CB  . CYS A 1 278 ? 173.57500 339.74000 31.10200  1.000 36.17568  ? 313 CYS F CB  1 
ATOM   1922 S SG  . CYS A 1 278 ? 174.38000 338.29200 30.39300  1.000 43.94998  ? 313 CYS F SG  1 
ATOM   1923 N N   . TRP A 1 279 ? 173.96100 342.59800 32.40300  1.000 34.09360  ? 314 TRP F N   1 
ATOM   1924 C CA  . TRP A 1 279 ? 173.40500 343.92800 32.60400  1.000 38.60879  ? 314 TRP F CA  1 
ATOM   1925 C C   . TRP A 1 279 ? 173.96400 344.87700 31.55700  1.000 36.31131  ? 314 TRP F C   1 
ATOM   1926 O O   . TRP A 1 279 ? 175.04600 344.66700 31.00700  1.000 32.19381  ? 314 TRP F O   1 
ATOM   1927 C CB  . TRP A 1 279 ? 173.68200 344.45800 34.01600  1.000 32.84113  ? 314 TRP F CB  1 
ATOM   1928 C CG  . TRP A 1 279 ? 175.14500 344.66500 34.35100  1.000 35.37884  ? 314 TRP F CG  1 
ATOM   1929 C CD1 . TRP A 1 279 ? 175.85100 345.83100 34.29000  1.000 38.37018  ? 314 TRP F CD1 1 
ATOM   1930 C CD2 . TRP A 1 279 ? 176.06100 343.67300 34.83500  1.000 36.27890  ? 314 TRP F CD2 1 
ATOM   1931 N NE1 . TRP A 1 279 ? 177.15800 345.62100 34.68600  1.000 36.30442  ? 314 TRP F NE1 1 
ATOM   1932 C CE2 . TRP A 1 279 ? 177.30400 344.30300 35.02900  1.000 37.39247  ? 314 TRP F CE2 1 
ATOM   1933 C CE3 . TRP A 1 279 ? 175.95300 342.30700 35.10600  1.000 38.23251  ? 314 TRP F CE3 1 
ATOM   1934 C CZ2 . TRP A 1 279 ? 178.43400 343.60800 35.48300  1.000 35.44437  ? 314 TRP F CZ2 1 
ATOM   1935 C CZ3 . TRP A 1 279 ? 177.07900 341.61900 35.55000  1.000 34.61027  ? 314 TRP F CZ3 1 
ATOM   1936 C CH2 . TRP A 1 279 ? 178.29600 342.27800 35.74200  1.000 34.60711  ? 314 TRP F CH2 1 
ATOM   1937 N N   . LYS A 1 280 ? 173.20700 345.92400 31.27300  1.000 35.62185  ? 315 LYS F N   1 
ATOM   1938 C CA  . LYS A 1 280 ? 173.57000 346.84000 30.20400  1.000 33.73969  ? 315 LYS F CA  1 
ATOM   1939 C C   . LYS A 1 280 ? 173.79700 348.21500 30.80300  1.000 33.35303  ? 315 LYS F C   1 
ATOM   1940 O O   . LYS A 1 280 ? 172.96300 348.68300 31.57900  1.000 34.90205  ? 315 LYS F O   1 
ATOM   1941 C CB  . LYS A 1 280 ? 172.51000 346.89200 29.10200  1.000 34.63496  ? 315 LYS F CB  1 
ATOM   1942 C CG  . LYS A 1 280 ? 172.99400 347.69000 27.88900  1.000 34.73320  ? 315 LYS F CG  1 
ATOM   1943 C CD  . LYS A 1 280 ? 172.11300 347.55200 26.65100  1.000 39.20307  ? 315 LYS F CD  1 
ATOM   1944 C CE  . LYS A 1 280 ? 172.80900 348.23300 25.46500  1.000 42.05327  ? 315 LYS F CE  1 
ATOM   1945 N NZ  . LYS A 1 280 ? 172.08800 348.10100 24.16200  1.000 46.63781  ? 315 LYS F NZ  1 
ATOM   1946 N N   . LEU A 1 281 ? 174.99600 348.76600 30.58300  1.000 29.39680  ? 316 LEU F N   1 
ATOM   1947 C CA  . LEU A 1 281 ? 175.38700 350.09800 31.07000  1.000 30.54782  ? 316 LEU F CA  1 
ATOM   1948 C C   . LEU A 1 281 ? 175.08500 351.13900 29.98700  1.000 30.65399  ? 316 LEU F C   1 
ATOM   1949 O O   . LEU A 1 281 ? 175.48700 350.96000 28.82100  1.000 31.42194  ? 316 LEU F O   1 
ATOM   1950 C CB  . LEU A 1 281 ? 176.87500 350.12100 31.43800  1.000 29.39914  ? 316 LEU F CB  1 
ATOM   1951 C CG  . LEU A 1 281 ? 177.43300 351.51000 31.78000  1.000 32.29838  ? 316 LEU F CG  1 
ATOM   1952 C CD1 . LEU A 1 281 ? 176.74700 352.08700 33.00800  1.000 28.39727  ? 316 LEU F CD1 1 
ATOM   1953 C CD2 . LEU A 1 281 ? 178.92700 351.38500 32.02200  1.000 29.87658  ? 316 LEU F CD2 1 
ATOM   1954 N N   . HIS A 1 282 ? 174.39200 352.22100 30.37600  1.000 31.28203  ? 317 HIS F N   1 
ATOM   1955 C CA  . HIS A 1 282 ? 174.05900 353.35400 29.51900  1.000 28.50966  ? 317 HIS F CA  1 
ATOM   1956 C C   . HIS A 1 282 ? 174.72600 354.61100 30.07300  1.000 29.06578  ? 317 HIS F C   1 
ATOM   1957 O O   . HIS A 1 282 ? 174.72100 354.81800 31.29100  1.000 27.01642  ? 317 HIS F O   1 
ATOM   1958 C CB  . HIS A 1 282 ? 172.54700 353.58900 29.54700  1.000 29.07795  ? 317 HIS F CB  1 
ATOM   1959 C CG  . HIS A 1 282 ? 171.74500 352.36700 29.24400  1.000 31.01560  ? 317 HIS F CG  1 
ATOM   1960 N ND1 . HIS A 1 282 ? 171.34300 352.00000 27.97500  1.000 37.75614  ? 317 HIS F ND1 1 
ATOM   1961 C CD2 . HIS A 1 282 ? 171.18600 351.46900 30.09200  1.000 30.32033  ? 317 HIS F CD2 1 
ATOM   1962 C CE1 . HIS A 1 282 ? 170.63000 350.88900 28.05000  1.000 32.46506  ? 317 HIS F CE1 1 
ATOM   1963 N NE2 . HIS A 1 282 ? 170.49200 350.56800 29.32900  1.000 34.50221  ? 317 HIS F NE2 1 
ATOM   1964 N N   . THR A 1 283 ? 175.38000 355.40100 29.21900  1.000 28.88582  ? 318 THR F N   1 
ATOM   1965 C CA  . THR A 1 283 ? 176.08800 356.61200 29.66600  1.000 30.29456  ? 318 THR F CA  1 
ATOM   1966 C C   . THR A 1 283 ? 175.67300 357.81700 28.83400  1.000 31.30113  ? 318 THR F C   1 
ATOM   1967 O O   . THR A 1 283 ? 175.20800 357.66400 27.70400  1.000 32.48988  ? 318 THR F O   1 
ATOM   1968 C CB  . THR A 1 283 ? 177.57000 356.45900 29.59000  1.000 29.42317  ? 318 THR F CB  1 
ATOM   1969 O OG1 . THR A 1 283 ? 177.92200 356.32000 28.21400  1.000 31.56198  ? 318 THR F OG1 1 
ATOM   1970 C CG2 . THR A 1 283 ? 177.95600 355.16400 30.32900  1.000 28.91561  ? 318 THR F CG2 1 
ATOM   1971 N N   . SER A 1 284 ? 175.78800 359.00900 29.41400  1.000 31.21098  ? 319 SER F N   1 
ATOM   1972 C CA  . SER A 1 284 ? 175.42500 360.24900 28.74100  1.000 31.24673  ? 319 SER F CA  1 
ATOM   1973 C C   . SER A 1 284 ? 176.30300 361.37400 29.28900  1.000 32.79240  ? 319 SER F C   1 
ATOM   1974 O O   . SER A 1 284 ? 176.80200 361.25800 30.41800  1.000 29.64760  ? 319 SER F O   1 
ATOM   1975 C CB  . SER A 1 284 ? 173.92500 360.52900 28.94900  1.000 32.15653  ? 319 SER F CB  1 
ATOM   1976 O OG  . SER A 1 284 ? 173.46900 361.55400 28.08700  1.000 37.62131  ? 319 SER F OG  1 
ATOM   1977 N N   . PRO A 1 285 ? 176.59400 362.41500 28.50100  1.000 30.30634  ? 320 PRO F N   1 
ATOM   1978 C CA  . PRO A 1 285 ? 177.49600 363.46400 28.99700  1.000 30.34281  ? 320 PRO F CA  1 
ATOM   1979 C C   . PRO A 1 285 ? 176.93500 364.18200 30.21500  1.000 32.72055  ? 320 PRO F C   1 
ATOM   1980 O O   . PRO A 1 285 ? 175.76900 364.60400 30.23200  1.000 30.06138  ? 320 PRO F O   1 
ATOM   1981 C CB  . PRO A 1 285 ? 177.64100 364.41100 27.80400  1.000 30.90762  ? 320 PRO F CB  1 
ATOM   1982 C CG  . PRO A 1 285 ? 177.34600 363.55700 26.60500  1.000 30.48582  ? 320 PRO F CG  1 
ATOM   1983 C CD  . PRO A 1 285 ? 176.27200 362.58500 27.08000  1.000 30.76533  ? 320 PRO F CD  1 
ATOM   1984 N N   . LEU A 1 286 ? 177.82700 364.42600 31.18000  1.000 30.90746  ? 321 LEU F N   1 
ATOM   1985 C CA  . LEU A 1 286 ? 177.55600 365.10300 32.45200  1.000 30.43884  ? 321 LEU F CA  1 
ATOM   1986 C C   . LEU A 1 286 ? 178.38200 366.38500 32.51100  1.000 33.76109  ? 321 LEU F C   1 
ATOM   1987 O O   . LEU A 1 286 ? 179.60300 366.32200 32.66000  1.000 33.44065  ? 321 LEU F O   1 
ATOM   1988 C CB  . LEU A 1 286 ? 177.91900 364.19700 33.63500  1.000 31.13695  ? 321 LEU F CB  1 
ATOM   1989 C CG  . LEU A 1 286 ? 177.62700 364.85700 34.98700  1.000 34.94511  ? 321 LEU F CG  1 
ATOM   1990 C CD1 . LEU A 1 286 ? 176.14700 365.00800 35.19000  1.000 30.97860  ? 321 LEU F CD1 1 
ATOM   1991 C CD2 . LEU A 1 286 ? 178.25200 364.04500 36.16800  1.000 34.87028  ? 321 LEU F CD2 1 
ATOM   1992 N N   . CYS A 1 287 ? 177.75600 367.53400 32.24200  1.000 34.87227  ? 322 CYS F N   1 
ATOM   1993 C CA  . CYS A 1 287 ? 178.46700 368.80700 32.22100  1.000 35.17510  ? 322 CYS F CA  1 
ATOM   1994 C C   . CYS A 1 287 ? 178.02300 369.72300 33.35400  1.000 35.48836  ? 322 CYS F C   1 
ATOM   1995 O O   . CYS A 1 287 ? 176.91800 369.58900 33.89900  1.000 36.92556  ? 322 CYS F O   1 
ATOM   1996 C CB  . CYS A 1 287 ? 178.21200 369.52100 30.89000  1.000 33.37880  ? 322 CYS F CB  1 
ATOM   1997 S SG  . CYS A 1 287 ? 178.56700 368.51800 29.42500  1.000 34.23524  ? 322 CYS F SG  1 
ATOM   1998 N N   . THR A 1 288 ? 178.81700 370.77400 33.59200  1.000 39.80723  ? 323 THR F N   1 
ATOM   1999 C CA  . THR A 1 288 ? 178.30900 371.75600 34.53300  1.000 38.62133  ? 323 THR F CA  1 
ATOM   2000 C C   . THR A 1 288 ? 177.42000 372.69100 33.72800  1.000 39.81870  ? 323 THR F C   1 
ATOM   2001 O O   . THR A 1 288 ? 177.54200 372.78300 32.49500  1.000 34.15183  ? 323 THR F O   1 
ATOM   2002 C CB  . THR A 1 288 ? 179.43900 372.58500 35.17600  1.000 41.14336  ? 323 THR F CB  1 
ATOM   2003 O OG1 . THR A 1 288 ? 180.25900 373.17400 34.14100  1.000 40.84762  ? 323 THR F OG1 1 
ATOM   2004 C CG2 . THR A 1 288 ? 180.29400 371.78700 36.15900  1.000 39.35743  ? 323 THR F CG2 1 
ATOM   2005 N N   . THR A 1 289 ? 176.52900 373.39100 34.43300  1.000 43.07642  ? 324 THR F N   1 
ATOM   2006 C CA  . THR A 1 289 ? 175.49300 374.21200 33.79500  1.000 51.73362  ? 324 THR F CA  1 
ATOM   2007 C C   . THR A 1 289 ? 175.65600 375.68800 34.12900  1.000 54.18603  ? 324 THR F C   1 
ATOM   2008 O O   . THR A 1 289 ? 174.67000 376.38000 34.40800  1.000 52.93468  ? 324 THR F O   1 
ATOM   2009 C CB  . THR A 1 289 ? 174.10900 373.73400 34.20300  1.000 41.24592  ? 324 THR F CB  1 
ATOM   2010 O OG1 . THR A 1 289 ? 174.01400 373.80000 35.62800  1.000 40.17991  ? 324 THR F OG1 1 
ATOM   2011 C CG2 . THR A 1 289 ? 173.89700 372.28100 33.72100  1.000 42.37681  ? 324 THR F CG2 1 
ATOM   2012 N N   . ASN A 1 290 ? 176.86200 376.20500 34.00100  1.000 55.01862  ? 325 ASN F N   1 
ATOM   2013 C CA  . ASN A 1 290 ? 177.03300 377.62800 34.18400  1.000 56.66564  ? 325 ASN F CA  1 
ATOM   2014 C C   . ASN A 1 290 ? 176.45200 378.36600 32.99300  1.000 64.57707  ? 325 ASN F C   1 
ATOM   2015 O O   . ASN A 1 290 ? 176.37500 377.84100 31.87400  1.000 59.93260  ? 325 ASN F O   1 
ATOM   2016 C CB  . ASN A 1 290 ? 178.51400 377.95200 34.34100  1.000 60.61434  ? 325 ASN F CB  1 
ATOM   2017 C CG  . ASN A 1 290 ? 178.95600 377.85800 35.76600  1.000 67.36449  ? 325 ASN F CG  1 
ATOM   2018 O OD1 . ASN A 1 290 ? 178.44300 378.55300 36.63800  1.000 80.66998  ? 325 ASN F OD1 1 
ATOM   2019 N ND2 . ASN A 1 290 ? 179.88800 376.93900 36.03000  1.000 63.02156  ? 325 ASN F ND2 1 
ATOM   2020 N N   . THR A 1 291 ? 176.14000 379.64100 33.23200  1.000 70.64183  ? 326 THR F N   1 
ATOM   2021 C CA  . THR A 1 291 ? 175.41300 380.50100 32.31000  1.000 72.44920  ? 326 THR F CA  1 
ATOM   2022 C C   . THR A 1 291 ? 176.33400 381.21100 31.33700  1.000 75.99229  ? 326 THR F C   1 
ATOM   2023 O O   . THR A 1 291 ? 175.84600 381.78500 30.35800  1.000 84.52370  ? 326 THR F O   1 
ATOM   2024 C CB  . THR A 1 291 ? 174.59400 381.54500 33.09900  1.000 77.77630  ? 326 THR F CB  1 
ATOM   2025 O OG1 . THR A 1 291 ? 175.39800 382.70700 33.35000  1.000 77.49351  ? 326 THR F OG1 1 
ATOM   2026 C CG2 . THR A 1 291 ? 174.12700 380.97500 34.44500  1.000 70.94281  ? 326 THR F CG2 1 
ATOM   2027 N N   . LYS A 1 292 ? 177.64300 381.06000 31.50900  1.000 74.51838  ? 327 LYS F N   1 
ATOM   2028 C CA  . LYS A 1 292 ? 178.64900 381.69800 30.67600  1.000 80.70340  ? 327 LYS F CA  1 
ATOM   2029 C C   . LYS A 1 292 ? 179.34700 380.58900 29.89600  1.000 84.95563  ? 327 LYS F C   1 
ATOM   2030 O O   . LYS A 1 292 ? 179.94700 379.68300 30.49200  1.000 78.11449  ? 327 LYS F O   1 
ATOM   2031 C CB  . LYS A 1 292 ? 179.63900 382.47100 31.55100  1.000 82.54718  ? 327 LYS F CB  1 
ATOM   2032 C CG  . LYS A 1 292 ? 180.79300 383.12700 30.80400  1.000 83.10409  ? 327 LYS F CG  1 
ATOM   2033 C CD  . LYS A 1 292 ? 182.13700 382.64700 31.34200  1.000 83.28488  ? 327 LYS F CD  1 
ATOM   2034 C CE  . LYS A 1 292 ? 182.79500 381.63300 30.40100  1.000 83.15009  ? 327 LYS F CE  1 
ATOM   2035 N NZ  . LYS A 1 292 ? 184.21700 381.34200 30.78200  1.000 82.88464  ? 327 LYS F NZ  1 
ATOM   2036 N N   . GLU A 1 293 ? 179.19800 380.63100 28.56700  1.000 87.58209  ? 328 GLU F N   1 
ATOM   2037 C CA  . GLU A 1 293 ? 179.79900 379.63100 27.68900  1.000 90.98612  ? 328 GLU F CA  1 
ATOM   2038 C C   . GLU A 1 293 ? 181.31800 379.72700 27.65000  1.000 84.74979  ? 328 GLU F C   1 
ATOM   2039 O O   . GLU A 1 293 ? 181.89000 380.82200 27.71400  1.000 81.92035  ? 328 GLU F O   1 
ATOM   2040 C CB  . GLU A 1 293 ? 179.25400 379.78300 26.26400  1.000 94.07382  ? 328 GLU F CB  1 
ATOM   2041 C CG  . GLU A 1 293 ? 177.81300 380.27600 26.19500  1.000 98.64919  ? 328 GLU F CG  1 
ATOM   2042 C CD  . GLU A 1 293 ? 177.07700 379.83700 24.92900  1.000 93.57512  ? 328 GLU F CD  1 
ATOM   2043 O OE1 . GLU A 1 293 ? 177.29200 378.69400 24.45500  1.000 91.97401  ? 328 GLU F OE1 1 
ATOM   2044 O OE2 . GLU A 1 293 ? 176.27300 380.65100 24.41400  1.000 89.28226  ? 328 GLU F OE2 1 
ATOM   2045 N N   . GLY A 1 294 ? 181.97600 378.56100 27.64400  1.000 77.82725  ? 329 GLY F N   1 
ATOM   2046 C CA  . GLY A 1 294 ? 183.40200 378.52600 27.82900  1.000 68.44939  ? 329 GLY F CA  1 
ATOM   2047 C C   . GLY A 1 294 ? 183.83300 378.26500 29.24400  1.000 73.59761  ? 329 GLY F C   1 
ATOM   2048 O O   . GLY A 1 294 ? 185.02700 378.02000 29.47800  1.000 79.90168  ? 329 GLY F O   1 
ATOM   2049 N N   . SER A 1 295 ? 182.89000 378.22300 30.18300  1.000 67.04167  ? 330 SER F N   1 
ATOM   2050 C CA  . SER A 1 295 ? 183.22600 377.96000 31.57300  1.000 69.49358  ? 330 SER F CA  1 
ATOM   2051 C C   . SER A 1 295 ? 182.67400 376.63900 32.06000  1.000 58.64481  ? 330 SER F C   1 
ATOM   2052 O O   . SER A 1 295 ? 182.68700 376.37700 33.27000  1.000 57.79948  ? 330 SER F O   1 
ATOM   2053 C CB  . SER A 1 295 ? 182.71100 379.08500 32.47800  1.000 69.49121  ? 330 SER F CB  1 
ATOM   2054 O OG  . SER A 1 295 ? 181.29200 379.16200 32.46800  1.000 67.32446  ? 330 SER F OG  1 
ATOM   2055 N N   . ASN A 1 296 ? 182.29600 375.75500 31.14800  1.000 52.53355  ? 331 ASN F N   1 
ATOM   2056 C CA  . ASN A 1 296 ? 181.69400 374.52200 31.60000  1.000 54.23323  ? 331 ASN F CA  1 
ATOM   2057 C C   . ASN A 1 296 ? 182.61400 373.37100 31.22700  1.000 46.37076  ? 331 ASN F C   1 
ATOM   2058 O O   . ASN A 1 296 ? 183.26300 373.38900 30.17800  1.000 50.24835  ? 331 ASN F O   1 
ATOM   2059 C CB  . ASN A 1 296 ? 180.34600 374.31300 30.92800  1.000 48.35625  ? 331 ASN F CB  1 
ATOM   2060 C CG  . ASN A 1 296 ? 179.27700 375.11500 31.59700  1.000 49.94402  ? 331 ASN F CG  1 
ATOM   2061 O OD1 . ASN A 1 296 ? 179.18900 375.16500 32.83200  1.000 46.55119  ? 331 ASN F OD1 1 
ATOM   2062 N ND2 . ASN A 1 296 ? 178.44000 375.73900 30.78700  1.000 42.99868  ? 331 ASN F ND2 1 
ATOM   2063 N N   . ILE A 1 297 ? 182.63600 372.35800 32.09000  1.000 47.13191  ? 332 ILE F N   1 
ATOM   2064 C CA  . ILE A 1 297 ? 183.44400 371.16400 31.88400  1.000 43.22022  ? 332 ILE F CA  1 
ATOM   2065 C C   . ILE A 1 297 ? 182.52300 369.95500 31.88700  1.000 39.75397  ? 332 ILE F C   1 
ATOM   2066 O O   . ILE A 1 297 ? 181.40900 370.01300 32.41800  1.000 37.19306  ? 332 ILE F O   1 
ATOM   2067 C CB  . ILE A 1 297 ? 184.51700 371.06700 32.98700  1.000 38.80939  ? 332 ILE F CB  1 
ATOM   2068 C CG1 . ILE A 1 297 ? 183.82200 371.09400 34.35100  1.000 36.70497  ? 332 ILE F CG1 1 
ATOM   2069 C CG2 . ILE A 1 297 ? 185.51400 372.21000 32.83900  1.000 45.63600  ? 332 ILE F CG2 1 
ATOM   2070 C CD1 . ILE A 1 297 ? 184.73100 371.00000 35.54500  1.000 41.97011  ? 332 ILE F CD1 1 
ATOM   2071 N N   . CYS A 1 298 ? 182.90900 368.93900 31.11700  1.000 37.00467  ? 333 CYS F N   1 
ATOM   2072 C CA  . CYS A 1 298 ? 182.10600 367.74300 30.93400  1.000 34.10375  ? 333 CYS F CA  1 
ATOM   2073 C C   . CYS A 1 298 ? 182.93900 366.48700 31.18700  1.000 37.46715  ? 333 CYS F C   1 
ATOM   2074 O O   . CYS A 1 298 ? 184.16000 366.47200 30.99400  1.000 35.17711  ? 333 CYS F O   1 
ATOM   2075 C CB  . CYS A 1 298 ? 181.58600 367.68500 29.49700  1.000 36.86165  ? 333 CYS F CB  1 
ATOM   2076 S SG  . CYS A 1 298 ? 180.51200 369.08500 29.06900  1.000 42.43647  ? 333 CYS F SG  1 
ATOM   2077 N N   . LEU A 1 299 ? 182.23600 365.39100 31.42300  1.000 33.50786  ? 334 LEU F N   1 
ATOM   2078 C CA  . LEU A 1 299 ? 182.80700 364.08300 31.71500  1.000 32.28861  ? 334 LEU F CA  1 
ATOM   2079 C C   . LEU A 1 299 ? 181.71800 363.08700 31.34200  1.000 33.74175  ? 334 LEU F C   1 
ATOM   2080 O O   . LEU A 1 299 ? 180.53000 363.39200 31.49800  1.000 33.13964  ? 334 LEU F O   1 
ATOM   2081 C CB  . LEU A 1 299 ? 183.36100 363.84500 33.12400  1.000 30.08813  ? 334 LEU F CB  1 
ATOM   2082 C CG  . LEU A 1 299 ? 182.49000 363.67500 34.35900  1.000 33.42426  ? 334 LEU F CG  1 
ATOM   2083 C CD1 . LEU A 1 299 ? 181.79100 362.30100 34.35100  1.000 29.68707  ? 334 LEU F CD1 1 
ATOM   2084 C CD2 . LEU A 1 299 ? 183.39500 363.80900 35.53500  1.000 32.42490  ? 334 LEU F CD2 1 
ATOM   2085 N N   . THR A 1 300 ? 182.11500 361.96100 30.75300  1.000 30.41580  ? 335 THR F N   1 
ATOM   2086 C CA  . THR A 1 300 ? 181.18100 360.92400 30.34000  1.000 29.37973  ? 335 THR F CA  1 
ATOM   2087 C C   . THR A 1 300 ? 181.85800 359.61900 30.71100  1.000 32.34973  ? 335 THR F C   1 
ATOM   2088 O O   . THR A 1 300 ? 183.04500 359.42100 30.45000  1.000 31.59434  ? 335 THR F O   1 
ATOM   2089 C CB  . THR A 1 300 ? 180.86800 360.91200 28.83700  1.000 30.13503  ? 335 THR F CB  1 
ATOM   2090 O OG1 . THR A 1 300 ? 180.56900 362.22800 28.35400  1.000 34.77102  ? 335 THR F OG1 1 
ATOM   2091 C CG2 . THR A 1 300 ? 179.75000 359.90900 28.47900  1.000 28.69483  ? 335 THR F CG2 1 
ATOM   2092 N N   . ARG A 1 301 ? 181.09800 358.75100 31.36900  1.000 28.62264  ? 336 ARG F N   1 
ATOM   2093 C CA  . ARG A 1 301 ? 181.60500 357.41100 31.63000  1.000 35.87849  ? 336 ARG F CA  1 
ATOM   2094 C C   . ARG A 1 301 ? 181.80100 356.65900 30.32500  1.000 35.09727  ? 336 ARG F C   1 
ATOM   2095 O O   . ARG A 1 301 ? 180.97200 356.70300 29.41100  1.000 34.79405  ? 336 ARG F O   1 
ATOM   2096 C CB  . ARG A 1 301 ? 180.63400 356.62800 32.52500  1.000 28.08915  ? 336 ARG F CB  1 
ATOM   2097 C CG  . ARG A 1 301 ? 180.58400 357.10600 33.98800  1.000 28.37933  ? 336 ARG F CG  1 
ATOM   2098 C CD  . ARG A 1 301 ? 179.64700 356.19600 34.75400  1.000 31.44842  ? 336 ARG F CD  1 
ATOM   2099 N NE  . ARG A 1 301 ? 180.10100 354.81400 34.68700  1.000 32.37173  ? 336 ARG F NE  1 
ATOM   2100 C CZ  . ARG A 1 301 ? 179.46600 353.77600 35.21400  1.000 35.91035  ? 336 ARG F CZ  1 
ATOM   2101 N NH1 . ARG A 1 301 ? 178.30100 353.91300 35.86500  1.000 30.62282  ? 336 ARG F NH1 1 
ATOM   2102 N NH2 . ARG A 1 301 ? 180.00900 352.57100 35.09700  1.000 32.75796  ? 336 ARG F NH2 1 
ATOM   2103 N N   . THR A 1 302 ? 182.84600 355.87400 30.27000  1.000 31.83868  ? 337 THR F N   1 
ATOM   2104 C CA  . THR A 1 302 ? 183.06000 355.13900 29.04600  1.000 34.98188  ? 337 THR F CA  1 
ATOM   2105 C C   . THR A 1 302 ? 182.70700 353.66200 29.28100  1.000 34.58776  ? 337 THR F C   1 
ATOM   2106 O O   . THR A 1 302 ? 182.18500 353.26100 30.33600  1.000 36.93370  ? 337 THR F O   1 
ATOM   2107 C CB  . THR A 1 302 ? 184.46600 355.39600 28.50900  1.000 38.76931  ? 337 THR F CB  1 
ATOM   2108 O OG1 . THR A 1 302 ? 185.42300 355.09500 29.50400  1.000 42.43892  ? 337 THR F OG1 1 
ATOM   2109 C CG2 . THR A 1 302 ? 184.60400 356.84200 28.08000  1.000 41.45258  ? 337 THR F CG2 1 
ATOM   2110 N N   . ASP A 1 303 ? 182.86900 352.86700 28.24200  1.000 32.58389  ? 338 ASP F N   1 
ATOM   2111 C CA  . ASP A 1 303 ? 182.56500 351.43300 28.28900  1.000 37.99546  ? 338 ASP F CA  1 
ATOM   2112 C C   . ASP A 1 303 ? 181.09600 351.14500 28.60900  1.000 39.37971  ? 338 ASP F C   1 
ATOM   2113 O O   . ASP A 1 303 ? 180.72900 350.22900 29.37300  1.000 35.95017  ? 338 ASP F O   1 
ATOM   2114 C CB  . ASP A 1 303 ? 183.48900 350.67200 29.25900  1.000 35.26755  ? 338 ASP F CB  1 
ATOM   2115 C CG  . ASP A 1 303 ? 184.97000 350.72400 28.84100  1.000 44.72498  ? 338 ASP F CG  1 
ATOM   2116 O OD1 . ASP A 1 303 ? 185.23200 350.81700 27.61600  1.000 47.91313  ? 338 ASP F OD1 1 
ATOM   2117 O OD2 . ASP A 1 303 ? 185.85500 350.61000 29.72100  1.000 43.74982  ? 338 ASP F OD2 1 
ATOM   2118 N N   . ARG A 1 304 ? 180.27600 351.71200 27.76500  1.000 36.78845  ? 339 ARG F N   1 
ATOM   2119 C CA  . ARG A 1 304 ? 178.86400 351.42100 27.79900  1.000 31.14716  ? 339 ARG F CA  1 
ATOM   2120 C C   . ARG A 1 304 ? 178.65100 350.17600 26.97400  1.000 30.38724  ? 339 ARG F C   1 
ATOM   2121 O O   . ARG A 1 304 ? 179.50100 349.81700 26.15300  1.000 29.40830  ? 339 ARG F O   1 
ATOM   2122 C CB  . ARG A 1 304 ? 178.09600 352.58400 27.17200  1.000 30.74223  ? 339 ARG F CB  1 
ATOM   2123 C CG  . ARG A 1 304 ? 178.46200 352.84100 25.65500  1.000 33.75439  ? 339 ARG F CG  1 
ATOM   2124 C CD  . ARG A 1 304 ? 177.37200 353.76100 24.98800  1.000 39.06259  ? 339 ARG F CD  1 
ATOM   2125 N NE  . ARG A 1 304 ? 177.44900 355.14200 25.48500  1.000 43.35655  ? 339 ARG F NE  1 
ATOM   2126 C CZ  . ARG A 1 304 ? 178.06100 356.18900 24.94200  1.000 52.91386  ? 339 ARG F CZ  1 
ATOM   2127 N NH1 . ARG A 1 304 ? 178.73300 356.08400 23.80500  1.000 60.45222  ? 339 ARG F NH1 1 
ATOM   2128 N NH2 . ARG A 1 304 ? 177.92000 357.39500 25.51900  1.000 39.26711  ? 339 ARG F NH2 1 
ATOM   2129 N N   . GLY A 1 305 ? 177.67600 349.38600 27.37400  1.000 30.19850  ? 340 GLY F N   1 
ATOM   2130 C CA  . GLY A 1 305 ? 177.38700 348.18700 26.62000  1.000 29.28523  ? 340 GLY F CA  1 
ATOM   2131 C C   . GLY A 1 305 ? 176.92000 347.06900 27.55100  1.000 31.34818  ? 340 GLY F C   1 
ATOM   2132 O O   . GLY A 1 305 ? 176.60300 347.29700 28.70900  1.000 28.20683  ? 340 GLY F O   1 
ATOM   2133 N N   . TRP A 1 306 ? 177.11400 345.84000 27.08600  1.000 30.99525  ? 341 TRP F N   1 
ATOM   2134 C CA  . TRP A 1 306 ? 176.67600 344.64500 27.79700  1.000 29.77778  ? 341 TRP F CA  1 
ATOM   2135 C C   . TRP A 1 306 ? 177.81600 344.06600 28.62300  1.000 31.80011  ? 341 TRP F C   1 
ATOM   2136 O O   . TRP A 1 306 ? 178.96400 344.00900 28.16300  1.000 30.83257  ? 341 TRP F O   1 
ATOM   2137 C CB  . TRP A 1 306 ? 176.10600 343.57100 26.86000  1.000 34.43904  ? 341 TRP F CB  1 
ATOM   2138 C CG  . TRP A 1 306 ? 174.66000 343.80700 26.45300  1.000 36.46069  ? 341 TRP F CG  1 
ATOM   2139 C CD1 . TRP A 1 306 ? 174.19600 344.27800 25.24300  1.000 35.43047  ? 341 TRP F CD1 1 
ATOM   2140 C CD2 . TRP A 1 306 ? 173.50400 343.65200 27.29000  1.000 32.45633  ? 341 TRP F CD2 1 
ATOM   2141 N NE1 . TRP A 1 306 ? 172.81500 344.36400 25.26800  1.000 36.70778  ? 341 TRP F NE1 1 
ATOM   2142 C CE2 . TRP A 1 306 ? 172.36700 343.99500 26.50900  1.000 37.49542  ? 341 TRP F CE2 1 
ATOM   2143 C CE3 . TRP A 1 306 ? 173.31500 343.23500 28.61300  1.000 33.70315  ? 341 TRP F CE3 1 
ATOM   2144 C CZ2 . TRP A 1 306 ? 171.06400 343.95500 27.01600  1.000 33.65572  ? 341 TRP F CZ2 1 
ATOM   2145 C CZ3 . TRP A 1 306 ? 172.00900 343.17600 29.11900  1.000 34.24349  ? 341 TRP F CZ3 1 
ATOM   2146 C CH2 . TRP A 1 306 ? 170.89700 343.55200 28.31500  1.000 37.78297  ? 341 TRP F CH2 1 
ATOM   2147 N N   . TYR A 1 307 ? 177.49200 343.73200 29.86800  1.000 32.50842  ? 342 TYR F N   1 
ATOM   2148 C CA  . TYR A 1 307 ? 178.32300 343.03200 30.83200  1.000 32.01867  ? 342 TYR F CA  1 
ATOM   2149 C C   . TYR A 1 307 ? 177.65200 341.74000 31.27500  1.000 36.79686  ? 342 TYR F C   1 
ATOM   2150 O O   . TYR A 1 307 ? 176.44200 341.73300 31.47700  1.000 35.38286  ? 342 TYR F O   1 
ATOM   2151 C CB  . TYR A 1 307 ? 178.55300 343.90500 32.05900  1.000 32.28815  ? 342 TYR F CB  1 
ATOM   2152 C CG  . TYR A 1 307 ? 179.33200 345.15100 31.75500  1.000 33.91046  ? 342 TYR F CG  1 
ATOM   2153 C CD1 . TYR A 1 307 ? 178.74400 346.26700 31.11500  1.000 29.67682  ? 342 TYR F CD1 1 
ATOM   2154 C CD2 . TYR A 1 307 ? 180.66600 345.21800 32.11300  1.000 27.24220  ? 342 TYR F CD2 1 
ATOM   2155 C CE1 . TYR A 1 307 ? 179.51300 347.41900 30.84400  1.000 28.69661  ? 342 TYR F CE1 1 
ATOM   2156 C CE2 . TYR A 1 307 ? 181.42900 346.34500 31.85500  1.000 32.62626  ? 342 TYR F CE2 1 
ATOM   2157 C CZ  . TYR A 1 307 ? 180.85100 347.43700 31.23300  1.000 32.77319  ? 342 TYR F CZ  1 
ATOM   2158 O OH  . TYR A 1 307 ? 181.65300 348.50900 31.00100  1.000 31.12814  ? 342 TYR F OH  1 
ATOM   2159 N N   . CYS A 1 308 ? 178.39300 340.62500 31.31200  1.000 32.80220  ? 343 CYS F N   1 
ATOM   2160 C CA  . CYS A 1 308 ? 177.80800 339.38000 31.81100  1.000 33.49304  ? 343 CYS F CA  1 
ATOM   2161 C C   . CYS A 1 308 ? 178.79800 338.70700 32.74900  1.000 31.21950  ? 343 CYS F C   1 
ATOM   2162 O O   . CYS A 1 308 ? 179.98100 338.61700 32.43900  1.000 32.48788  ? 343 CYS F O   1 
ATOM   2163 C CB  . CYS A 1 308 ? 177.43600 338.37100 30.72400  1.000 30.98633  ? 343 CYS F CB  1 
ATOM   2164 S SG  . CYS A 1 308 ? 176.17000 338.90000 29.52700  1.000 41.22699  ? 343 CYS F SG  1 
ATOM   2165 N N   . ASP A 1 309 ? 178.29200 338.15600 33.84500  1.000 32.10289  ? 344 ASP F N   1 
ATOM   2166 C CA  . ASP A 1 309 ? 179.13000 337.35600 34.73500  1.000 35.13235  ? 344 ASP F CA  1 
ATOM   2167 C C   . ASP A 1 309 ? 179.57400 336.09800 33.99500  1.000 34.31454  ? 344 ASP F C   1 
ATOM   2168 O O   . ASP A 1 309 ? 178.79300 335.52700 33.22800  1.000 31.70188  ? 344 ASP F O   1 
ATOM   2169 C CB  . ASP A 1 309 ? 178.40300 336.95300 36.00700  1.000 33.91920  ? 344 ASP F CB  1 
ATOM   2170 C CG  . ASP A 1 309 ? 178.19300 338.11000 36.97400  1.000 41.16062  ? 344 ASP F CG  1 
ATOM   2171 O OD1 . ASP A 1 309 ? 179.05900 338.99600 37.07200  1.000 45.48725  ? 344 ASP F OD1 1 
ATOM   2172 O OD2 . ASP A 1 309 ? 177.22600 338.06100 37.75500  1.000 49.33849  ? 344 ASP F OD2 1 
ATOM   2173 N N   . ASN A 1 310 ? 180.87500 335.79600 34.06400  1.000 29.71543  ? 345 ASN F N   1 
ATOM   2174 C CA  . ASN A 1 310 ? 181.48100 334.67500 33.34200  1.000 31.13360  ? 345 ASN F CA  1 
ATOM   2175 C C   . ASN A 1 310 ? 182.73300 334.13600 34.03100  1.000 30.43170  ? 345 ASN F C   1 
ATOM   2176 O O   . ASN A 1 310 ? 183.78100 334.78800 34.00900  1.000 29.49674  ? 345 ASN F O   1 
ATOM   2177 C CB  . ASN A 1 310 ? 181.76400 335.09300 31.89600  1.000 30.26942  ? 345 ASN F CB  1 
ATOM   2178 C CG  . ASN A 1 310 ? 182.27000 333.95300 31.05000  1.000 30.23208  ? 345 ASN F CG  1 
ATOM   2179 O OD1 . ASN A 1 310 ? 182.30200 332.79600 31.48700  1.000 30.59148  ? 345 ASN F OD1 1 
ATOM   2180 N ND2 . ASN A 1 310 ? 182.57700 334.25100 29.80000  1.000 26.53062  ? 345 ASN F ND2 1 
ATOM   2181 N N   . ALA A 1 311 ? 182.61500 332.96700 34.68000  1.000 32.54291  ? 346 ALA F N   1 
ATOM   2182 C CA  . ALA A 1 311 ? 183.76700 332.21000 35.20700  1.000 28.49050  ? 346 ALA F CA  1 
ATOM   2183 C C   . ALA A 1 311 ? 184.62000 333.03600 36.16300  1.000 29.88014  ? 346 ALA F C   1 
ATOM   2184 O O   . ALA A 1 311 ? 185.85400 333.03000 36.09000  1.000 30.85216  ? 346 ALA F O   1 
ATOM   2185 C CB  . ALA A 1 311 ? 184.63000 331.65300 34.06300  1.000 26.31357  ? 346 ALA F CB  1 
ATOM   2186 N N   . GLY A 1 312 ? 183.97700 333.64800 37.15200  1.000 30.04422  ? 347 GLY F N   1 
ATOM   2187 C CA  . GLY A 1 312 ? 184.71800 334.42300 38.12700  1.000 33.04739  ? 347 GLY F CA  1 
ATOM   2188 C C   . GLY A 1 312 ? 185.15800 335.79700 37.67100  1.000 33.52325  ? 347 GLY F C   1 
ATOM   2189 O O   . GLY A 1 312 ? 185.61700 336.59200 38.50900  1.000 35.13275  ? 347 GLY F O   1 
ATOM   2190 N N   . SER A 1 313 ? 184.96200 336.13100 36.39700  1.000 34.16469  ? 348 SER F N   1 
ATOM   2191 C CA  . SER A 1 313 ? 185.25300 337.44300 35.81700  1.000 34.65002  ? 348 SER F CA  1 
ATOM   2192 C C   . SER A 1 313 ? 183.96700 337.98300 35.17700  1.000 31.99884  ? 348 SER F C   1 
ATOM   2193 O O   . SER A 1 313 ? 182.87400 337.47600 35.43100  1.000 31.27101  ? 348 SER F O   1 
ATOM   2194 C CB  . SER A 1 313 ? 186.35600 337.35000 34.76400  1.000 34.90517  ? 348 SER F CB  1 
ATOM   2195 O OG  . SER A 1 313 ? 187.57800 336.98600 35.32300  1.000 37.03105  ? 348 SER F OG  1 
ATOM   2196 N N   . VAL A 1 314 ? 184.08300 339.11700 34.48000  1.000 31.68775  ? 349 VAL F N   1 
ATOM   2197 C CA  . VAL A 1 314 ? 183.00600 339.74700 33.71500  1.000 29.33831  ? 349 VAL F CA  1 
ATOM   2198 C C   . VAL A 1 314 ? 183.36800 339.80500 32.22600  1.000 30.74393  ? 349 VAL F C   1 
ATOM   2199 O O   . VAL A 1 314 ? 184.45500 340.25200 31.87100  1.000 31.32580  ? 349 VAL F O   1 
ATOM   2200 C CB  . VAL A 1 314 ? 182.65400 341.12600 34.29200  1.000 29.38668  ? 349 VAL F CB  1 
ATOM   2201 C CG1 . VAL A 1 314 ? 181.65800 341.82300 33.41300  1.000 32.80949  ? 349 VAL F CG1 1 
ATOM   2202 C CG2 . VAL A 1 314 ? 181.99400 340.91200 35.66000  1.000 27.02213  ? 349 VAL F CG2 1 
ATOM   2203 N N   . SER A 1 315 ? 182.49100 339.32800 31.36000  1.000 30.04656  ? 350 SER F N   1 
ATOM   2204 C CA  . SER A 1 315 ? 182.67700 339.44200 29.91900  1.000 30.21015  ? 350 SER F CA  1 
ATOM   2205 C C   . SER A 1 315 ? 181.96900 340.71700 29.46700  1.000 32.88491  ? 350 SER F C   1 
ATOM   2206 O O   . SER A 1 315 ? 180.78100 340.89100 29.74500  1.000 28.77116  ? 350 SER F O   1 
ATOM   2207 C CB  . SER A 1 315 ? 182.08500 338.24300 29.17700  1.000 29.34009  ? 350 SER F CB  1 
ATOM   2208 O OG  . SER A 1 315 ? 182.87700 337.08700 29.33200  1.000 30.25022  ? 350 SER F OG  1 
ATOM   2209 N N   . PHE A 1 316 ? 182.74300 341.67700 28.95800  1.000 31.75037  ? 351 PHE F N   1 
ATOM   2210 C CA  . PHE A 1 316 ? 182.25200 342.95100 28.44200  1.000 27.98325  ? 351 PHE F CA  1 
ATOM   2211 C C   . PHE A 1 316 ? 182.20100 342.94200 26.92100  1.000 31.74181  ? 351 PHE F C   1 
ATOM   2212 O O   . PHE A 1 316 ? 183.18700 342.58700 26.28000  1.000 27.61425  ? 351 PHE F O   1 
ATOM   2213 C CB  . PHE A 1 316 ? 183.14500 344.08800 28.95700  1.000 26.82219  ? 351 PHE F CB  1 
ATOM   2214 C CG  . PHE A 1 316 ? 182.88900 345.42300 28.30000  1.000 33.57642  ? 351 PHE F CG  1 
ATOM   2215 C CD1 . PHE A 1 316 ? 181.63300 346.03300 28.33000  1.000 31.12614  ? 351 PHE F CD1 1 
ATOM   2216 C CD2 . PHE A 1 316 ? 183.95200 346.11900 27.74300  1.000 33.14901  ? 351 PHE F CD2 1 
ATOM   2217 C CE1 . PHE A 1 316 ? 181.43100 347.26200 27.71100  1.000 32.89749  ? 351 PHE F CE1 1 
ATOM   2218 C CE2 . PHE A 1 316 ? 183.76900 347.35200 27.14400  1.000 29.74501  ? 351 PHE F CE2 1 
ATOM   2219 C CZ  . PHE A 1 316 ? 182.50200 347.92700 27.12700  1.000 33.06207  ? 351 PHE F CZ  1 
ATOM   2220 N N   . PHE A 1 317 ? 181.09800 343.43200 26.35200  1.000 29.70616  ? 352 PHE F N   1 
ATOM   2221 C CA  . PHE A 1 317 ? 180.89600 343.47200 24.90000  1.000 31.00214  ? 352 PHE F CA  1 
ATOM   2222 C C   . PHE A 1 317 ? 180.79900 344.93300 24.48100  1.000 35.02078  ? 352 PHE F C   1 
ATOM   2223 O O   . PHE A 1 317 ? 179.72900 345.55700 24.59800  1.000 34.97539  ? 352 PHE F O   1 
ATOM   2224 C CB  . PHE A 1 317 ? 179.65300 342.65400 24.51800  1.000 32.32744  ? 352 PHE F CB  1 
ATOM   2225 C CG  . PHE A 1 317 ? 179.71200 341.23000 25.06400  1.000 32.33631  ? 352 PHE F CG  1 
ATOM   2226 C CD1 . PHE A 1 317 ? 179.23100 340.90000 26.31400  1.000 32.32201  ? 352 PHE F CD1 1 
ATOM   2227 C CD2 . PHE A 1 317 ? 180.29900 340.23000 24.30500  1.000 36.77660  ? 352 PHE F CD2 1 
ATOM   2228 C CE1 . PHE A 1 317 ? 179.35200 339.59800 26.80400  1.000 35.33493  ? 352 PHE F CE1 1 
ATOM   2229 C CE2 . PHE A 1 317 ? 180.42200 338.92900 24.79100  1.000 32.46912  ? 352 PHE F CE2 1 
ATOM   2230 C CZ  . PHE A 1 317 ? 179.94200 338.61100 26.02500  1.000 31.25855  ? 352 PHE F CZ  1 
ATOM   2231 N N   . PRO A 1 318 ? 181.88000 345.51200 23.95900  1.000 36.30736  ? 353 PRO F N   1 
ATOM   2232 C CA  . PRO A 1 318 ? 181.84100 346.95200 23.62000  1.000 42.70117  ? 353 PRO F CA  1 
ATOM   2233 C C   . PRO A 1 318 ? 181.04900 347.29900 22.35700  1.000 44.30119  ? 353 PRO F C   1 
ATOM   2234 O O   . PRO A 1 318 ? 180.43600 348.37000 22.34400  1.000 49.30554  ? 353 PRO F O   1 
ATOM   2235 C CB  . PRO A 1 318 ? 183.33300 347.32500 23.51200  1.000 35.50493  ? 353 PRO F CB  1 
ATOM   2236 C CG  . PRO A 1 318 ? 184.00900 346.04700 23.14500  1.000 36.63579  ? 353 PRO F CG  1 
ATOM   2237 C CD  . PRO A 1 318 ? 183.23200 344.93500 23.83100  1.000 32.63601  ? 353 PRO F CD  1 
ATOM   2238 N N   . GLN A 1 319 ? 181.11700 346.50300 21.27500  1.000 46.60632  ? 354 GLN F N   1 
ATOM   2239 C CA  . GLN A 1 319 ? 180.35000 346.80200 20.06100  1.000 51.51837  ? 354 GLN F CA  1 
ATOM   2240 C C   . GLN A 1 319 ? 178.85700 346.54500 20.24500  1.000 55.94840  ? 354 GLN F C   1 
ATOM   2241 O O   . GLN A 1 319 ? 178.44300 345.47600 20.70700  1.000 47.93640  ? 354 GLN F O   1 
ATOM   2242 C CB  . GLN A 1 319 ? 180.82400 346.04600 18.81600  1.000 50.29618  ? 354 GLN F CB  1 
ATOM   2243 C CG  . GLN A 1 319 ? 182.29700 345.70800 18.63300  1.000 62.02405  ? 354 GLN F CG  1 
ATOM   2244 C CD  . GLN A 1 319 ? 182.82200 344.55800 19.50700  1.000 66.31471  ? 354 GLN F CD  1 
ATOM   2245 O OE1 . GLN A 1 319 ? 182.28100 344.22300 20.60100  1.000 63.61754  ? 354 GLN F OE1 1 
ATOM   2246 N NE2 . GLN A 1 319 ? 183.89400 343.92400 19.00800  1.000 67.80192  ? 354 GLN F NE2 1 
ATOM   2247 N N   . ALA A 1 320 ? 178.04300 347.41000 19.63200  1.000 64.19200  ? 355 ALA F N   1 
ATOM   2248 C CA  . ALA A 1 320 ? 176.60700 347.37200 19.89300  1.000 63.81220  ? 355 ALA F CA  1 
ATOM   2249 C C   . ALA A 1 320 ? 175.89200 346.24300 19.16500  1.000 60.86479  ? 355 ALA F C   1 
ATOM   2250 O O   . ALA A 1 320 ? 174.89900 345.71500 19.67100  1.000 65.46457  ? 355 ALA F O   1 
ATOM   2251 C CB  . ALA A 1 320 ? 175.98800 348.72100 19.50900  1.000 58.34840  ? 355 ALA F CB  1 
ATOM   2252 N N   . GLU A 1 321 ? 176.37400 345.83900 18.01300  1.000 59.91051  ? 356 GLU F N   1 
ATOM   2253 C CA  . GLU A 1 321 ? 175.69300 344.82000 17.23000  1.000 67.08014  ? 356 GLU F CA  1 
ATOM   2254 C C   . GLU A 1 321 ? 176.09000 343.38200 17.55800  1.000 62.25311  ? 356 GLU F C   1 
ATOM   2255 O O   . GLU A 1 321 ? 175.51600 342.46300 16.96900  1.000 64.29185  ? 356 GLU F O   1 
ATOM   2256 C CB  . GLU A 1 321 ? 175.99200 345.09700 15.76200  1.000 72.73968  ? 356 GLU F CB  1 
ATOM   2257 C CG  . GLU A 1 321 ? 177.45100 344.76900 15.42000  1.000 77.30456  ? 356 GLU F CG  1 
ATOM   2258 C CD  . GLU A 1 321 ? 178.46900 345.84500 15.90500  1.000 83.28970  ? 356 GLU F CD  1 
ATOM   2259 O OE1 . GLU A 1 321 ? 178.05800 346.90100 16.47200  1.000 78.22449  ? 356 GLU F OE1 1 
ATOM   2260 O OE2 . GLU A 1 321 ? 179.69700 345.61900 15.71200  1.000 84.21087  ? 356 GLU F OE2 1 
ATOM   2261 N N   . THR A 1 322 ? 177.00800 343.14700 18.50300  1.000 59.90936  ? 357 THR F N   1 
ATOM   2262 C CA  . THR A 1 322 ? 177.44600 341.79000 18.83200  1.000 52.73200  ? 357 THR F CA  1 
ATOM   2263 C C   . THR A 1 322 ? 176.57300 341.02700 19.82000  1.000 52.92528  ? 357 THR F C   1 
ATOM   2264 O O   . THR A 1 322 ? 176.74100 339.80700 19.91300  1.000 55.46674  ? 357 THR F O   1 
ATOM   2265 C CB  . THR A 1 322 ? 178.87900 341.81900 19.39600  1.000 49.21554  ? 357 THR F CB  1 
ATOM   2266 O OG1 . THR A 1 322 ? 178.93600 342.69700 20.52000  1.000 55.82210  ? 357 THR F OG1 1 
ATOM   2267 C CG2 . THR A 1 322 ? 179.88300 342.28200 18.35700  1.000 58.00553  ? 357 THR F CG2 1 
ATOM   2268 N N   . CYS A 1 323 ? 175.50300 341.60000 20.34100  1.000 46.91935  ? 358 CYS F N   1 
ATOM   2269 C CA  . CYS A 1 323 ? 174.65600 340.90400 21.30400  1.000 47.89789  ? 358 CYS F CA  1 
ATOM   2270 C C   . CYS A 1 323 ? 173.19800 341.07200 20.92600  1.000 53.36513  ? 358 CYS F C   1 
ATOM   2271 O O   . CYS A 1 323 ? 172.72300 342.19400 20.73300  1.000 55.41234  ? 358 CYS F O   1 
ATOM   2272 C CB  . CYS A 1 323 ? 174.84900 341.40500 22.75700  1.000 42.20612  ? 358 CYS F CB  1 
ATOM   2273 S SG  . CYS A 1 323 ? 176.41400 340.97900 23.67600  1.000 44.12336  ? 358 CYS F SG  1 
ATOM   2274 N N   . LYS A 1 324 ? 172.55200 339.94700 20.66200  1.000 48.02292  ? 359 LYS F N   1 
ATOM   2275 C CA  . LYS A 1 324 ? 171.13000 339.90400 20.37100  1.000 47.99540  ? 359 LYS F CA  1 
ATOM   2276 C C   . LYS A 1 324 ? 170.35200 339.58000 21.63600  1.000 46.93617  ? 359 LYS F C   1 
ATOM   2277 O O   . LYS A 1 324 ? 170.71100 338.66700 22.37900  1.000 45.54147  ? 359 LYS F O   1 
ATOM   2278 C CB  . LYS A 1 324 ? 170.81200 338.83400 19.31900  1.000 47.36039  ? 359 LYS F CB  1 
ATOM   2279 C CG  . LYS A 1 324 ? 171.84300 338.68000 18.19900  1.000 51.65636  ? 359 LYS F CG  1 
ATOM   2280 C CD  . LYS A 1 324 ? 171.72000 339.82400 17.24500  1.000 59.80491  ? 359 LYS F CD  1 
ATOM   2281 C CE  . LYS A 1 324 ? 172.34800 339.50900 15.91800  1.000 63.73938  ? 359 LYS F CE  1 
ATOM   2282 N NZ  . LYS A 1 324 ? 171.78900 340.43500 14.89100  1.000 72.07271  ? 359 LYS F NZ  1 
ATOM   2283 N N   . VAL A 1 325 ? 169.26400 340.30000 21.87200  1.000 46.51609  ? 360 VAL F N   1 
ATOM   2284 C CA  . VAL A 1 325 ? 168.47500 340.11200 23.07500  1.000 54.68454  ? 360 VAL F CA  1 
ATOM   2285 C C   . VAL A 1 325 ? 167.12800 339.55200 22.63200  1.000 61.68038  ? 360 VAL F C   1 
ATOM   2286 O O   . VAL A 1 325 ? 166.51700 340.05300 21.68200  1.000 61.77302  ? 360 VAL F O   1 
ATOM   2287 C CB  . VAL A 1 325 ? 168.28900 341.43900 23.82600  1.000 48.95557  ? 360 VAL F CB  1 
ATOM   2288 C CG1 . VAL A 1 325 ? 167.52700 341.21900 25.10400  1.000 54.48359  ? 360 VAL F CG1 1 
ATOM   2289 C CG2 . VAL A 1 325 ? 169.62000 342.04900 24.12800  1.000 48.79938  ? 360 VAL F CG2 1 
ATOM   2290 N N   . GLN A 1 326 ? 166.68600 338.49600 23.30300  1.000 53.64822  ? 361 GLN F N   1 
ATOM   2291 C CA  . GLN A 1 326 ? 165.34600 337.94500 23.13600  1.000 63.40556  ? 361 GLN F CA  1 
ATOM   2292 C C   . GLN A 1 326 ? 164.72800 337.78200 24.51200  1.000 62.19000  ? 361 GLN F C   1 
ATOM   2293 O O   . GLN A 1 326 ? 165.21900 336.98500 25.31800  1.000 60.34502  ? 361 GLN F O   1 
ATOM   2294 C CB  . GLN A 1 326 ? 165.33900 336.62600 22.37300  1.000 68.67744  ? 361 GLN F CB  1 
ATOM   2295 C CG  . GLN A 1 326 ? 164.09400 336.51600 21.51300  1.000 80.01147  ? 361 GLN F CG  1 
ATOM   2296 C CD  . GLN A 1 326 ? 162.97500 335.76500 22.23500  1.000 81.98718  ? 361 GLN F CD  1 
ATOM   2297 O OE1 . GLN A 1 326 ? 163.16200 334.63600 22.69500  1.000 81.10916  ? 361 GLN F OE1 1 
ATOM   2298 N NE2 . GLN A 1 326 ? 161.82700 336.42200 22.39200  1.000 87.06101  ? 361 GLN F NE2 1 
ATOM   2299 N N   . SER A 1 327 ? 163.67500 338.54400 24.79100  1.000 73.19530  ? 362 SER F N   1 
ATOM   2300 C CA  . SER A 1 327 ? 163.09000 338.52200 26.12300  1.000 68.57403  ? 362 SER F CA  1 
ATOM   2301 C C   . SER A 1 327 ? 164.10100 339.11500 27.10200  1.000 68.79760  ? 362 SER F C   1 
ATOM   2302 O O   . SER A 1 327 ? 164.56200 340.24900 26.91200  1.000 70.37436  ? 362 SER F O   1 
ATOM   2303 C CB  . SER A 1 327 ? 162.69700 337.09300 26.51200  1.000 66.81497  ? 362 SER F CB  1 
ATOM   2304 O OG  . SER A 1 327 ? 163.70200 336.50300 27.34200  1.000 66.19467  ? 362 SER F OG  1 
ATOM   2305 N N   . ASN A 1 328 ? 164.46100 338.35900 28.14100  1.000 57.84800  ? 363 ASN F N   1 
ATOM   2306 C CA  . ASN A 1 328 ? 165.51300 338.75100 29.06300  1.000 50.46693  ? 363 ASN F CA  1 
ATOM   2307 C C   . ASN A 1 328 ? 166.78900 337.92700 28.86800  1.000 44.57553  ? 363 ASN F C   1 
ATOM   2308 O O   . ASN A 1 328 ? 167.53800 337.72500 29.82000  1.000 44.77027  ? 363 ASN F O   1 
ATOM   2309 C CB  . ASN A 1 328 ? 165.01500 338.63700 30.50600  1.000 53.30777  ? 363 ASN F CB  1 
ATOM   2310 C CG  . ASN A 1 328 ? 164.56400 337.21600 30.87000  1.000 65.76526  ? 363 ASN F CG  1 
ATOM   2311 O OD1 . ASN A 1 328 ? 164.15900 336.43200 29.98600  1.000 67.48108  ? 363 ASN F OD1 1 
ATOM   2312 N ND2 . ASN A 1 328 ? 164.64500 336.87000 32.18000  1.000 55.67469  ? 363 ASN F ND2 1 
ATOM   2313 N N   . ARG A 1 329 ? 167.05300 337.43000 27.66500  1.000 40.21485  ? 364 ARG F N   1 
ATOM   2314 C CA  . ARG A 1 329 ? 168.24100 336.62300 27.44000  1.000 45.25075  ? 364 ARG F CA  1 
ATOM   2315 C C   . ARG A 1 329 ? 169.14100 337.29500 26.41000  1.000 43.03884  ? 364 ARG F C   1 
ATOM   2316 O O   . ARG A 1 329 ? 168.66900 337.70200 25.34400  1.000 44.28371  ? 364 ARG F O   1 
ATOM   2317 C CB  . ARG A 1 329 ? 167.87200 335.19700 26.99200  1.000 44.80165  ? 364 ARG F CB  1 
ATOM   2318 C CG  . ARG A 1 329 ? 169.11200 334.27300 26.91200  1.000 44.14940  ? 364 ARG F CG  1 
ATOM   2319 C CD  . ARG A 1 329 ? 168.74300 332.80900 26.83000  1.000 47.24899  ? 364 ARG F CD  1 
ATOM   2320 N NE  . ARG A 1 329 ? 167.90900 332.40600 27.96000  1.000 49.15121  ? 364 ARG F NE  1 
ATOM   2321 C CZ  . ARG A 1 329 ? 168.38500 331.92900 29.10100  1.000 46.28350  ? 364 ARG F CZ  1 
ATOM   2322 N NH1 . ARG A 1 329 ? 169.69300 331.77100 29.29800  1.000 38.53236  ? 364 ARG F NH1 1 
ATOM   2323 N NH2 . ARG A 1 329 ? 167.53500 331.59800 30.06600  1.000 47.19303  ? 364 ARG F NH2 1 
ATOM   2324 N N   . VAL A 1 330 ? 170.43400 337.42800 26.73000  1.000 42.93655  ? 365 VAL F N   1 
ATOM   2325 C CA  . VAL A 1 330 ? 171.40500 338.01500 25.80300  1.000 39.27779  ? 365 VAL F CA  1 
ATOM   2326 C C   . VAL A 1 330 ? 172.21000 336.88100 25.19200  1.000 34.89391  ? 365 VAL F C   1 
ATOM   2327 O O   . VAL A 1 330 ? 172.90700 336.17100 25.92000  1.000 43.98500  ? 365 VAL F O   1 
ATOM   2328 C CB  . VAL A 1 330 ? 172.29500 339.01100 26.58500  1.000 36.73681  ? 365 VAL F CB  1 
ATOM   2329 C CG1 . VAL A 1 330 ? 173.06100 339.98000 25.67900  1.000 35.25141  ? 365 VAL F CG1 1 
ATOM   2330 C CG2 . VAL A 1 330 ? 171.41700 339.80300 27.52700  1.000 37.58547  ? 365 VAL F CG2 1 
ATOM   2331 N N   . PHE A 1 331 ? 172.40100 336.93500 23.88200  1.000 37.79825  ? 366 PHE F N   1 
ATOM   2332 C CA  . PHE A 1 331 ? 173.13500 335.93000 23.12600  1.000 37.04290  ? 366 PHE F CA  1 
ATOM   2333 C C   . PHE A 1 331 ? 174.28700 336.67900 22.48300  1.000 40.22340  ? 366 PHE F C   1 
ATOM   2334 O O   . PHE A 1 331 ? 174.07000 337.54700 21.63000  1.000 41.88717  ? 366 PHE F O   1 
ATOM   2335 C CB  . PHE A 1 331 ? 172.26700 335.32400 22.02600  1.000 38.17455  ? 366 PHE F CB  1 
ATOM   2336 C CG  . PHE A 1 331 ? 171.12600 334.47100 22.49800  1.000 40.08408  ? 366 PHE F CG  1 
ATOM   2337 C CD1 . PHE A 1 331 ? 169.92700 335.04800 22.90700  1.000 43.83245  ? 366 PHE F CD1 1 
ATOM   2338 C CD2 . PHE A 1 331 ? 171.20800 333.08400 22.41900  1.000 40.64588  ? 366 PHE F CD2 1 
ATOM   2339 C CE1 . PHE A 1 331 ? 168.84900 334.25400 23.29700  1.000 44.90374  ? 366 PHE F CE1 1 
ATOM   2340 C CE2 . PHE A 1 331 ? 170.13600 332.28200 22.80800  1.000 38.43317  ? 366 PHE F CE2 1 
ATOM   2341 C CZ  . PHE A 1 331 ? 168.96200 332.85700 23.23400  1.000 36.59227  ? 366 PHE F CZ  1 
ATOM   2342 N N   . CYS A 1 332 ? 175.45900 336.48000 23.05500  1.000 41.21841  ? 367 CYS F N   1 
ATOM   2343 C CA  . CYS A 1 332 ? 176.70800 337.11100 22.67400  1.000 39.56747  ? 367 CYS F CA  1 
ATOM   2344 C C   . CYS A 1 332 ? 177.71100 336.06500 22.18700  1.000 39.41625  ? 367 CYS F C   1 
ATOM   2345 O O   . CYS A 1 332 ? 177.66800 334.89600 22.58800  1.000 39.35610  ? 367 CYS F O   1 
ATOM   2346 C CB  . CYS A 1 332 ? 177.26600 337.84600 23.87500  1.000 36.45024  ? 367 CYS F CB  1 
ATOM   2347 S SG  . CYS A 1 332 ? 176.10700 339.04500 24.48900  1.000 43.30893  ? 367 CYS F SG  1 
ATOM   2348 N N   . ASP A 1 333 ? 178.73000 336.53300 21.49600  1.000 41.00076  ? 368 ASP F N   1 
ATOM   2349 C CA  . ASP A 1 333 ? 179.85000 335.71800 21.03500  1.000 39.43070  ? 368 ASP F CA  1 
ATOM   2350 C C   . ASP A 1 333 ? 181.03300 336.24000 21.83300  1.000 39.00093  ? 368 ASP F C   1 
ATOM   2351 O O   . ASP A 1 333 ? 181.35200 337.42500 21.74600  1.000 36.38980  ? 368 ASP F O   1 
ATOM   2352 C CB  . ASP A 1 333 ? 180.10600 335.84900 19.52600  1.000 39.87820  ? 368 ASP F CB  1 
ATOM   2353 C CG  . ASP A 1 333 ? 181.07400 334.78400 19.00900  1.000 40.87231  ? 368 ASP F CG  1 
ATOM   2354 O OD1 . ASP A 1 333 ? 182.05500 334.51900 19.74400  1.000 40.15899  ? 368 ASP F OD1 1 
ATOM   2355 O OD2 . ASP A 1 333 ? 180.92400 334.22100 17.91700  1.000 48.24228  ? 368 ASP F OD2 1 
ATOM   2356 N N   . THR A 1 334 ? 181.69800 335.33700 22.58200  1.000 33.27394  ? 369 THR F N   1 
ATOM   2357 C CA  . THR A 1 334 ? 182.80500 335.77400 23.42500  1.000 37.38416  ? 369 THR F CA  1 
ATOM   2358 C C   . THR A 1 334 ? 184.01000 336.18200 22.61900  1.000 38.98101  ? 369 THR F C   1 
ATOM   2359 O O   . THR A 1 334 ? 184.89500 336.86900 23.14600  1.000 38.02712  ? 369 THR F O   1 
ATOM   2360 C CB  . THR A 1 334 ? 183.20700 334.63100 24.37600  1.000 38.19509  ? 369 THR F CB  1 
ATOM   2361 O OG1 . THR A 1 334 ? 183.64100 333.50800 23.59100  1.000 35.15720  ? 369 THR F OG1 1 
ATOM   2362 C CG2 . THR A 1 334 ? 182.12800 334.26300 25.40400  1.000 33.04542  ? 369 THR F CG2 1 
ATOM   2363 N N   . MET A 1 335 ? 183.95200 335.92700 21.33000  1.000 34.49233  ? 370 MET F N   1 
ATOM   2364 C CA  . MET A 1 335 ? 184.98700 336.30500 20.39100  1.000 43.61444  ? 370 MET F CA  1 
ATOM   2365 C C   . MET A 1 335 ? 185.11100 337.82700 20.41700  1.000 45.10655  ? 370 MET F C   1 
ATOM   2366 O O   . MET A 1 335 ? 186.19700 338.38000 20.21300  1.000 45.50736  ? 370 MET F O   1 
ATOM   2367 C CB  . MET A 1 335 ? 184.66800 335.73200 19.01600  1.000 45.11625  ? 370 MET F CB  1 
ATOM   2368 C CG  . MET A 1 335 ? 185.63400 336.11100 17.94100  1.000 60.95784  ? 370 MET F CG  1 
ATOM   2369 S SD  . MET A 1 335 ? 185.95400 334.56300 17.03100  1.000 84.99557  ? 370 MET F SD  1 
ATOM   2370 C CE  . MET A 1 335 ? 187.30700 333.84100 17.99400  1.000 54.58892  ? 370 MET F CE  1 
ATOM   2371 N N   . ASN A 1 336 ? 183.98700 338.53400 20.60300  1.000 38.73477  ? 371 ASN F N   1 
ATOM   2372 C CA  . ASN A 1 336 ? 184.14100 339.97900 20.62600  1.000 49.65108  ? 371 ASN F CA  1 
ATOM   2373 C C   . ASN A 1 336 ? 183.78900 340.49500 22.01100  1.000 42.43050  ? 371 ASN F C   1 
ATOM   2374 O O   . ASN A 1 336 ? 182.94400 341.38900 22.16400  1.000 42.40506  ? 371 ASN F O   1 
ATOM   2375 C CB  . ASN A 1 336 ? 183.17000 340.70500 19.67700  1.000 50.22870  ? 371 ASN F CB  1 
ATOM   2376 C CG  . ASN A 1 336 ? 182.87000 339.95400 18.38900  1.000 51.76481  ? 371 ASN F CG  1 
ATOM   2377 O OD1 . ASN A 1 336 ? 181.87200 339.23100 18.28500  1.000 50.62313  ? 371 ASN F OD1 1 
ATOM   2378 N ND2 . ASN A 1 336 ? 183.74200 340.13000 17.39500  1.000 55.19322  ? 371 ASN F ND2 1 
ATOM   2379 N N   . SER A 1 337 ? 184.58100 340.07800 22.99900  1.000 35.99368  ? 372 SER F N   1 
ATOM   2380 C CA  . SER A 1 337 ? 184.36500 340.47700 24.37900  1.000 34.15304  ? 372 SER F CA  1 
ATOM   2381 C C   . SER A 1 337 ? 185.73800 340.83300 24.90700  1.000 30.63682  ? 372 SER F C   1 
ATOM   2382 O O   . SER A 1 337 ? 186.76900 340.44800 24.34500  1.000 32.87379  ? 372 SER F O   1 
ATOM   2383 C CB  . SER A 1 337 ? 183.71600 339.40300 25.27900  1.000 32.93543  ? 372 SER F CB  1 
ATOM   2384 O OG  . SER A 1 337 ? 184.53200 338.21900 25.40700  1.000 33.39885  ? 372 SER F OG  1 
ATOM   2385 N N   . LEU A 1 338 ? 185.73700 341.53600 26.01000  1.000 33.06200  ? 373 LEU F N   1 
ATOM   2386 C CA  . LEU A 1 338 ? 186.89800 341.75700 26.84400  1.000 31.55624  ? 373 LEU F CA  1 
ATOM   2387 C C   . LEU A 1 338 ? 186.59100 341.11600 28.18700  1.000 35.27307  ? 373 LEU F C   1 
ATOM   2388 O O   . LEU A 1 338 ? 185.43700 341.07900 28.60200  1.000 30.92627  ? 373 LEU F O   1 
ATOM   2389 C CB  . LEU A 1 338 ? 187.17100 343.25300 26.99000  1.000 31.27702  ? 373 LEU F CB  1 
ATOM   2390 C CG  . LEU A 1 338 ? 187.42000 343.97600 25.63500  1.000 42.02471  ? 373 LEU F CG  1 
ATOM   2391 C CD1 . LEU A 1 338 ? 187.72800 345.50300 25.77800  1.000 32.11972  ? 373 LEU F CD1 1 
ATOM   2392 C CD2 . LEU A 1 338 ? 188.56700 343.30000 24.89000  1.000 40.83515  ? 373 LEU F CD2 1 
ATOM   2393 N N   . THR A 1 339 ? 187.61200 340.57100 28.84500  1.000 33.48183  ? 374 THR F N   1 
ATOM   2394 C CA  . THR A 1 339 ? 187.47400 339.92500 30.15100  1.000 31.93950  ? 374 THR F CA  1 
ATOM   2395 C C   . THR A 1 339 ? 187.91100 340.92700 31.20400  1.000 29.88974  ? 374 THR F C   1 
ATOM   2396 O O   . THR A 1 339 ? 189.05400 341.35900 31.19600  1.000 24.82782  ? 374 THR F O   1 
ATOM   2397 C CB  . THR A 1 339 ? 188.30500 338.64000 30.22700  1.000 34.44596  ? 374 THR F CB  1 
ATOM   2398 O OG1 . THR A 1 339 ? 187.90200 337.77900 29.16700  1.000 36.08630  ? 374 THR F OG1 1 
ATOM   2399 C CG2 . THR A 1 339 ? 188.06100 337.93000 31.52900  1.000 30.16534  ? 374 THR F CG2 1 
ATOM   2400 N N   . LEU A 1 340 ? 187.01100 341.29000 32.11100  1.000 31.00613  ? 375 LEU F N   1 
ATOM   2401 C CA  . LEU A 1 340 ? 187.31700 342.28500 33.10400  1.000 30.65555  ? 375 LEU F CA  1 
ATOM   2402 C C   . LEU A 1 340 ? 187.17300 341.70900 34.49300  1.000 32.89497  ? 375 LEU F C   1 
ATOM   2403 O O   . LEU A 1 340 ? 186.39800 340.77000 34.70000  1.000 31.05201  ? 375 LEU F O   1 
ATOM   2404 C CB  . LEU A 1 340 ? 186.34000 343.47100 32.98500  1.000 30.27475  ? 375 LEU F CB  1 
ATOM   2405 C CG  . LEU A 1 340 ? 186.24400 344.11800 31.58700  1.000 34.20060  ? 375 LEU F CG  1 
ATOM   2406 C CD1 . LEU A 1 340 ? 185.22900 345.22700 31.61800  1.000 34.31662  ? 375 LEU F CD1 1 
ATOM   2407 C CD2 . LEU A 1 340 ? 187.57500 344.61400 31.06100  1.000 33.40280  ? 375 LEU F CD2 1 
ATOM   2408 N N   . PRO A 1 341 ? 187.89300 342.24600 35.47000  1.000 34.01496  ? 376 PRO F N   1 
ATOM   2409 C CA  . PRO A 1 341 ? 187.66400 341.79500 36.85200  1.000 31.81299  ? 376 PRO F CA  1 
ATOM   2410 C C   . PRO A 1 341 ? 186.25400 342.14600 37.26600  1.000 36.52616  ? 376 PRO F C   1 
ATOM   2411 O O   . PRO A 1 341 ? 185.70200 343.16200 36.83700  1.000 38.39551  ? 376 PRO F O   1 
ATOM   2412 C CB  . PRO A 1 341 ? 188.67900 342.60600 37.67200  1.000 33.97577  ? 376 PRO F CB  1 
ATOM   2413 C CG  . PRO A 1 341 ? 188.98300 343.83500 36.79200  1.000 37.57959  ? 376 PRO F CG  1 
ATOM   2414 C CD  . PRO A 1 341 ? 188.90700 343.31400 35.36000  1.000 24.42475  ? 376 PRO F CD  1 
ATOM   2415 N N   . SER A 1 342 ? 185.68100 341.32600 38.16000  1.000 32.30995  ? 377 SER F N   1 
ATOM   2416 C CA  . SER A 1 342 ? 184.31600 341.58500 38.60100  1.000 36.22581  ? 377 SER F CA  1 
ATOM   2417 C C   . SER A 1 342 ? 184.20900 342.91800 39.33600  1.000 35.47301  ? 377 SER F C   1 
ATOM   2418 O O   . SER A 1 342 ? 183.11400 343.50300 39.41300  1.000 37.96182  ? 377 SER F O   1 
ATOM   2419 C CB  . SER A 1 342 ? 183.80800 340.44300 39.48300  1.000 32.86760  ? 377 SER F CB  1 
ATOM   2420 O OG  . SER A 1 342 ? 184.62100 340.30900 40.62300  1.000 43.92292  ? 377 SER F OG  1 
ATOM   2421 N N   . GLU A 1 343 ? 185.33900 343.49900 39.72100  1.000 37.33269  ? 378 GLU F N   1 
ATOM   2422 C CA  . GLU A 1 343 ? 185.28400 344.79000 40.38100  1.000 40.19028  ? 378 GLU F CA  1 
ATOM   2423 C C   . GLU A 1 343 ? 184.86100 345.89700 39.41300  1.000 39.57707  ? 378 GLU F C   1 
ATOM   2424 O O   . GLU A 1 343 ? 184.58800 347.01200 39.86200  1.000 35.44882  ? 378 GLU F O   1 
ATOM   2425 C CB  . GLU A 1 343 ? 186.62800 345.14700 41.02800  1.000 39.43332  ? 378 GLU F CB  1 
ATOM   2426 C CG  . GLU A 1 343 ? 187.01600 344.38400 42.31900  1.000 39.99109  ? 378 GLU F CG  1 
ATOM   2427 C CD  . GLU A 1 343 ? 187.29400 342.89400 42.15700  1.000 41.28448  ? 378 GLU F CD  1 
ATOM   2428 O OE1 . GLU A 1 343 ? 187.90100 342.45300 41.15300  1.000 40.41974  ? 378 GLU F OE1 1 
ATOM   2429 O OE2 . GLU A 1 343 ? 186.88400 342.15100 43.06400  1.000 50.41977  ? 378 GLU F OE2 1 
ATOM   2430 N N   . VAL A 1 344 ? 184.72400 345.59900 38.11700  1.000 34.02140  ? 379 VAL F N   1 
ATOM   2431 C CA  . VAL A 1 344 ? 184.30000 346.62800 37.18800  1.000 39.12886  ? 379 VAL F CA  1 
ATOM   2432 C C   . VAL A 1 344 ? 182.86900 347.04800 37.53300  1.000 39.74273  ? 379 VAL F C   1 
ATOM   2433 O O   . VAL A 1 344 ? 182.53300 348.22600 37.41500  1.000 37.28050  ? 379 VAL F O   1 
ATOM   2434 C CB  . VAL A 1 344 ? 184.37200 346.13100 35.72800  1.000 35.00271  ? 379 VAL F CB  1 
ATOM   2435 C CG1 . VAL A 1 344 ? 183.24400 345.12000 35.44700  1.000 32.98898  ? 379 VAL F CG1 1 
ATOM   2436 C CG2 . VAL A 1 344 ? 184.19400 347.31400 34.77700  1.000 39.54885  ? 379 VAL F CG2 1 
ATOM   2437 N N   . ASN A 1 345 ? 182.11400 346.19500 38.21700  1.000 37.68911  ? 380 ASN F N   1 
ATOM   2438 C CA  . ASN A 1 345 ? 180.76000 346.60800 38.58600  1.000 39.52986  ? 380 ASN F CA  1 
ATOM   2439 C C   . ASN A 1 345 ? 180.75700 347.68600 39.65200  1.000 42.51477  ? 380 ASN F C   1 
ATOM   2440 O O   . ASN A 1 345 ? 179.74000 348.37000 39.84800  1.000 41.29372  ? 380 ASN F O   1 
ATOM   2441 C CB  . ASN A 1 345 ? 179.90200 345.46600 39.12400  1.000 36.88179  ? 380 ASN F CB  1 
ATOM   2442 C CG  . ASN A 1 345 ? 178.46100 345.93100 39.40100  1.000 50.41274  ? 380 ASN F CG  1 
ATOM   2443 O OD1 . ASN A 1 345 ? 177.79200 346.47500 38.50800  1.000 43.05229  ? 380 ASN F OD1 1 
ATOM   2444 N ND2 . ASN A 1 345 ? 178.00600 345.78400 40.65000  1.000 49.84155  ? 380 ASN F ND2 1 
ATOM   2445 N N   . LEU A 1 346 ? 181.87100 347.91000 40.30100  1.000 38.11292  ? 381 LEU F N   1 
ATOM   2446 C CA  . LEU A 1 346 ? 181.79900 348.91000 41.33500  1.000 41.46302  ? 381 LEU F CA  1 
ATOM   2447 C C   . LEU A 1 346 ? 181.79100 350.32000 40.75600  1.000 43.80339  ? 381 LEU F C   1 
ATOM   2448 O O   . LEU A 1 346 ? 181.47300 351.27400 41.47600  1.000 42.71125  ? 381 LEU F O   1 
ATOM   2449 C CB  . LEU A 1 346 ? 183.07500 348.71000 42.16400  1.000 45.64745  ? 381 LEU F CB  1 
ATOM   2450 C CG  . LEU A 1 346 ? 183.13500 347.67100 43.30200  1.000 49.49718  ? 381 LEU F CG  1 
ATOM   2451 C CD1 . LEU A 1 346 ? 184.56700 347.63000 43.86400  1.000 39.61856  ? 381 LEU F CD1 1 
ATOM   2452 C CD2 . LEU A 1 346 ? 182.04200 347.72000 44.38300  1.000 48.38861  ? 381 LEU F CD2 1 
ATOM   2453 N N   . CYS A 1 347 ? 181.93700 350.47400 39.43700  1.000 42.78873  ? 382 CYS F N   1 
ATOM   2454 C CA  . CYS A 1 347 ? 181.79500 351.82700 38.91400  1.000 44.19151  ? 382 CYS F CA  1 
ATOM   2455 C C   . CYS A 1 347 ? 180.33900 352.24800 38.99700  1.000 42.70310  ? 382 CYS F C   1 
ATOM   2456 O O   . CYS A 1 347 ? 180.02000 353.43900 38.92200  1.000 43.23596  ? 382 CYS F O   1 
ATOM   2457 C CB  . CYS A 1 347 ? 182.29800 351.87400 37.47500  1.000 36.37221  ? 382 CYS F CB  1 
ATOM   2458 S SG  . CYS A 1 347 ? 184.09100 351.56300 37.45400  1.000 46.68024  ? 382 CYS F SG  1 
ATOM   2459 N N   . ASN A 1 348 ? 179.46000 351.26600 39.09100  1.000 38.69045  ? 383 ASN F N   1 
ATOM   2460 C CA  . ASN A 1 348 ? 178.03800 351.47000 39.24300  1.000 39.63560  ? 383 ASN F CA  1 
ATOM   2461 C C   . ASN A 1 348 ? 177.64100 351.77600 40.67400  1.000 45.89817  ? 383 ASN F C   1 
ATOM   2462 O O   . ASN A 1 348 ? 176.47900 352.12300 40.89800  1.000 46.24700  ? 383 ASN F O   1 
ATOM   2463 C CB  . ASN A 1 348 ? 177.24300 350.37700 38.57800  1.000 34.54715  ? 383 ASN F CB  1 
ATOM   2464 C CG  . ASN A 1 348 ? 177.73000 350.17300 37.19300  1.000 38.44986  ? 383 ASN F CG  1 
ATOM   2465 O OD1 . ASN A 1 348 ? 177.59200 351.07100 36.35300  1.000 36.23222  ? 383 ASN F OD1 1 
ATOM   2466 N ND2 . ASN A 1 348 ? 178.08100 348.94300 36.86900  1.000 33.87560  ? 383 ASN F ND2 1 
ATOM   2467 N N   . VAL A 1 349 ? 178.45000 351.41500 41.67100  1.000 47.43392  ? 384 VAL F N   1 
ATOM   2468 C CA  . VAL A 1 349 ? 178.06400 351.72000 43.03100  1.000 42.00087  ? 384 VAL F CA  1 
ATOM   2469 C C   . VAL A 1 349 ? 178.85300 352.88100 43.63500  1.000 46.18216  ? 384 VAL F C   1 
ATOM   2470 O O   . VAL A 1 349 ? 178.26600 353.68800 44.36500  1.000 48.78504  ? 384 VAL F O   1 
ATOM   2471 C CB  . VAL A 1 349 ? 178.33100 350.43300 43.84700  1.000 47.30048  ? 384 VAL F CB  1 
ATOM   2472 C CG1 . VAL A 1 349 ? 177.90200 350.57300 45.32200  1.000 50.48539  ? 384 VAL F CG1 1 
ATOM   2473 C CG2 . VAL A 1 349 ? 177.78900 349.18000 43.15200  1.000 47.20730  ? 384 VAL F CG2 1 
ATOM   2474 N N   . ASP A 1 350 ? 180.13400 353.03000 43.29800  1.000 39.99120  ? 385 ASP F N   1 
ATOM   2475 C CA  . ASP A 1 350 ? 181.00500 354.10800 43.78600  1.000 41.60342  ? 385 ASP F CA  1 
ATOM   2476 C C   . ASP A 1 350 ? 182.01500 354.42200 42.68600  1.000 43.17695  ? 385 ASP F C   1 
ATOM   2477 O O   . ASP A 1 350 ? 183.02900 353.72900 42.61500  1.000 41.54370  ? 385 ASP F O   1 
ATOM   2478 C CB  . ASP A 1 350 ? 181.67000 353.76100 45.11200  1.000 51.44572  ? 385 ASP F CB  1 
ATOM   2479 C CG  . ASP A 1 350 ? 182.57000 354.89200 45.64600  1.000 50.85960  ? 385 ASP F CG  1 
ATOM   2480 O OD1 . ASP A 1 350 ? 182.39400 356.07800 45.25600  1.000 47.37403  ? 385 ASP F OD1 1 
ATOM   2481 O OD2 . ASP A 1 350 ? 183.46400 354.57300 46.46700  1.000 59.58680  ? 385 ASP F OD2 1 
ATOM   2482 N N   . ILE A 1 351 ? 181.81000 355.45900 41.87000  1.000 44.88015  ? 386 ILE F N   1 
ATOM   2483 C CA  . ILE A 1 351 ? 182.78100 355.60900 40.78000  1.000 42.75154  ? 386 ILE F CA  1 
ATOM   2484 C C   . ILE A 1 351 ? 184.19700 355.93400 41.30700  1.000 42.12883  ? 386 ILE F C   1 
ATOM   2485 O O   . ILE A 1 351 ? 185.17900 355.78700 40.56700  1.000 42.97178  ? 386 ILE F O   1 
ATOM   2486 C CB  . ILE A 1 351 ? 182.23100 356.63200 39.75900  1.000 41.42460  ? 386 ILE F CB  1 
ATOM   2487 C CG1 . ILE A 1 351 ? 183.03200 356.58000 38.47000  1.000 40.81288  ? 386 ILE F CG1 1 
ATOM   2488 C CG2 . ILE A 1 351 ? 182.31400 358.04000 40.29800  1.000 40.68294  ? 386 ILE F CG2 1 
ATOM   2489 C CD1 . ILE A 1 351 ? 182.47900 357.46700 37.42100  1.000 46.20162  ? 386 ILE F CD1 1 
ATOM   2490 N N   . PHE A 1 352 ? 184.30200 356.46100 42.52700  1.000 40.46268  ? 387 PHE F N   1 
ATOM   2491 C CA  . PHE A 1 352 ? 185.48100 356.88600 43.29400  1.000 42.95606  ? 387 PHE F CA  1 
ATOM   2492 C C   . PHE A 1 352 ? 186.12500 355.74900 44.11900  1.000 49.62269  ? 387 PHE F C   1 
ATOM   2493 O O   . PHE A 1 352 ? 187.09700 356.00500 44.83600  1.000 53.98324  ? 387 PHE F O   1 
ATOM   2494 C CB  . PHE A 1 352 ? 185.11500 358.06800 44.18800  1.000 41.97963  ? 387 PHE F CB  1 
ATOM   2495 C CG  . PHE A 1 352 ? 184.94300 359.33500 43.42800  1.000 45.16265  ? 387 PHE F CG  1 
ATOM   2496 C CD1 . PHE A 1 352 ? 185.88300 359.70600 42.47900  1.000 44.47137  ? 387 PHE F CD1 1 
ATOM   2497 C CD2 . PHE A 1 352 ? 183.74900 360.03800 43.49400  1.000 41.03058  ? 387 PHE F CD2 1 
ATOM   2498 C CE1 . PHE A 1 352 ? 185.71900 360.84500 41.72500  1.000 38.80810  ? 387 PHE F CE1 1 
ATOM   2499 C CE2 . PHE A 1 352 ? 183.57000 361.16700 42.73500  1.000 39.30020  ? 387 PHE F CE2 1 
ATOM   2500 C CZ  . PHE A 1 352 ? 184.55800 361.56500 41.84500  1.000 43.78408  ? 387 PHE F CZ  1 
ATOM   2501 N N   . ASN A 1 353 ? 185.75600 354.50100 43.87500  1.000 41.57068  ? 388 ASN F N   1 
ATOM   2502 C CA  . ASN A 1 353 ? 186.13900 353.28800 44.62200  1.000 48.55924  ? 388 ASN F CA  1 
ATOM   2503 C C   . ASN A 1 353 ? 187.52400 352.80900 44.22100  1.000 49.02634  ? 388 ASN F C   1 
ATOM   2504 O O   . ASN A 1 353 ? 187.87100 352.84600 43.03900  1.000 53.00148  ? 388 ASN F O   1 
ATOM   2505 C CB  . ASN A 1 353 ? 185.17400 352.15700 44.33400  1.000 40.83891  ? 388 ASN F CB  1 
ATOM   2506 C CG  . ASN A 1 353 ? 185.55900 351.42700 43.07100  1.000 49.18752  ? 388 ASN F CG  1 
ATOM   2507 O OD1 . ASN A 1 353 ? 186.47300 350.59200 43.08200  1.000 49.30227  ? 388 ASN F OD1 1 
ATOM   2508 N ND2 . ASN A 1 353 ? 184.92300 351.79300 41.94300  1.000 45.67563  ? 388 ASN F ND2 1 
ATOM   2509 N N   . PRO A 1 354 ? 188.42200 352.61600 45.19600  1.000 53.87100  ? 389 PRO F N   1 
ATOM   2510 C CA  . PRO A 1 354 ? 189.79000 352.20000 44.85100  1.000 52.20916  ? 389 PRO F CA  1 
ATOM   2511 C C   . PRO A 1 354 ? 189.96700 350.80500 44.30200  1.000 49.26880  ? 389 PRO F C   1 
ATOM   2512 O O   . PRO A 1 354 ? 191.08200 350.51600 43.85900  1.000 58.85043  ? 389 PRO F O   1 
ATOM   2513 C CB  . PRO A 1 354 ? 190.47900 352.17200 46.22500  1.000 57.53791  ? 389 PRO F CB  1 
ATOM   2514 C CG  . PRO A 1 354 ? 189.61300 352.92100 47.16700  1.000 58.64358  ? 389 PRO F CG  1 
ATOM   2515 C CD  . PRO A 1 354 ? 188.20500 352.68300 46.65000  1.000 59.59550  ? 389 PRO F CD  1 
ATOM   2516 N N   . LYS A 1 355 ? 188.98500 349.90800 44.32500  1.000 49.10504  ? 390 LYS F N   1 
ATOM   2517 C CA  . LYS A 1 355 ? 189.31900 348.59300 43.77500  1.000 47.69499  ? 390 LYS F CA  1 
ATOM   2518 C C   . LYS A 1 355 ? 189.44100 348.56100 42.23800  1.000 48.23278  ? 390 LYS F C   1 
ATOM   2519 O O   . LYS A 1 355 ? 190.19500 347.74000 41.69300  1.000 50.69858  ? 390 LYS F O   1 
ATOM   2520 C CB  . LYS A 1 355 ? 188.24100 347.62900 44.24000  1.000 45.76152  ? 390 LYS F CB  1 
ATOM   2521 C CG  . LYS A 1 355 ? 188.25100 347.44400 45.75300  1.000 50.50825  ? 390 LYS F CG  1 
ATOM   2522 C CD  . LYS A 1 355 ? 188.62100 346.05400 46.19100  1.000 67.26280  ? 390 LYS F CD  1 
ATOM   2523 C CE  . LYS A 1 355 ? 188.58600 345.98900 47.71600  1.000 72.98286  ? 390 LYS F CE  1 
ATOM   2524 N NZ  . LYS A 1 355 ? 187.31900 345.36200 48.19000  1.000 69.22808  ? 390 LYS F NZ  1 
ATOM   2525 N N   . TYR A 1 356 ? 188.71100 349.42700 41.51900  1.000 43.32515  ? 391 TYR F N   1 
ATOM   2526 C CA  . TYR A 1 356 ? 188.78800 349.50400 40.06200  1.000 41.05444  ? 391 TYR F CA  1 
ATOM   2527 C C   . TYR A 1 356 ? 188.86700 350.94700 39.56600  1.000 42.74695  ? 391 TYR F C   1 
ATOM   2528 O O   . TYR A 1 356 ? 188.08100 351.78500 40.00900  1.000 41.69567  ? 391 TYR F O   1 
ATOM   2529 C CB  . TYR A 1 356 ? 187.57400 348.77500 39.45100  1.000 38.32582  ? 391 TYR F CB  1 
ATOM   2530 C CG  . TYR A 1 356 ? 187.58800 348.65400 37.93600  1.000 43.69943  ? 391 TYR F CG  1 
ATOM   2531 C CD1 . TYR A 1 356 ? 187.01800 349.64700 37.12400  1.000 36.84276  ? 391 TYR F CD1 1 
ATOM   2532 C CD2 . TYR A 1 356 ? 188.17100 347.54900 37.30600  1.000 42.51088  ? 391 TYR F CD2 1 
ATOM   2533 C CE1 . TYR A 1 356 ? 187.02900 349.53000 35.72600  1.000 37.31554  ? 391 TYR F CE1 1 
ATOM   2534 C CE2 . TYR A 1 356 ? 188.19300 347.43500 35.89400  1.000 39.89113  ? 391 TYR F CE2 1 
ATOM   2535 C CZ  . TYR A 1 356 ? 187.61700 348.43400 35.12500  1.000 42.85778  ? 391 TYR F CZ  1 
ATOM   2536 O OH  . TYR A 1 356 ? 187.63100 348.33900 33.74500  1.000 48.64007  ? 391 TYR F OH  1 
ATOM   2537 N N   . ASP A 1 357 ? 189.78700 351.25100 38.65900  1.000 41.70133  ? 392 ASP F N   1 
ATOM   2538 C CA  . ASP A 1 357 ? 189.93400 352.62300 38.15200  1.000 43.03626  ? 392 ASP F CA  1 
ATOM   2539 C C   . ASP A 1 357 ? 188.85200 352.95800 37.10100  1.000 35.61083  ? 392 ASP F C   1 
ATOM   2540 O O   . ASP A 1 357 ? 189.04000 352.79600 35.90500  1.000 38.50660  ? 392 ASP F O   1 
ATOM   2541 C CB  . ASP A 1 357 ? 191.34600 352.85500 37.63700  1.000 44.46514  ? 392 ASP F CB  1 
ATOM   2542 C CG  . ASP A 1 357 ? 191.63700 354.32300 37.43100  1.000 44.01602  ? 392 ASP F CG  1 
ATOM   2543 O OD1 . ASP A 1 357 ? 190.92600 355.15700 38.06000  1.000 43.42535  ? 392 ASP F OD1 1 
ATOM   2544 O OD2 . ASP A 1 357 ? 192.56500 354.63100 36.64300  1.000 45.76789  ? 392 ASP F OD2 1 
ATOM   2545 N N   . CYS A 1 358 ? 187.66900 353.35600 37.55000  1.000 42.30677  ? 393 CYS F N   1 
ATOM   2546 C CA  . CYS A 1 358 ? 186.56300 353.84700 36.70700  1.000 39.46769  ? 393 CYS F CA  1 
ATOM   2547 C C   . CYS A 1 358 ? 186.91300 354.77800 35.55400  1.000 38.43884  ? 393 CYS F C   1 
ATOM   2548 O O   . CYS A 1 358 ? 187.58800 355.78000 35.78500  1.000 41.81894  ? 393 CYS F O   1 
ATOM   2549 C CB  . CYS A 1 358 ? 185.42400 354.39000 37.54800  1.000 44.92764  ? 393 CYS F CB  1 
ATOM   2550 S SG  . CYS A 1 358 ? 184.90400 353.04300 38.66000  1.000 49.04188  ? 393 CYS F SG  1 
ATOM   2551 N N   . LYS A 1 359 ? 186.70100 354.35200 34.30600  1.000 34.56138  ? 394 LYS F N   1 
ATOM   2552 C CA  . LYS A 1 359 ? 187.20900 355.11400 33.17800  1.000 44.40839  ? 394 LYS F CA  1 
ATOM   2553 C C   . LYS A 1 359 ? 186.17900 356.15300 32.70200  1.000 41.42813  ? 394 LYS F C   1 
ATOM   2554 O O   . LYS A 1 359 ? 184.96200 355.92700 32.73500  1.000 37.17412  ? 394 LYS F O   1 
ATOM   2555 C CB  . LYS A 1 359 ? 187.45700 354.12300 32.02400  1.000 49.17866  ? 394 LYS F CB  1 
ATOM   2556 C CG  . LYS A 1 359 ? 188.51200 352.99600 32.32700  1.000 46.15753  ? 394 LYS F CG  1 
ATOM   2557 C CD  . LYS A 1 359 ? 189.24100 352.51500 31.05600  1.000 61.36871  ? 394 LYS F CD  1 
ATOM   2558 C CE  . LYS A 1 359 ? 188.30200 352.42600 29.83700  1.000 60.46908  ? 394 LYS F CE  1 
ATOM   2559 N NZ  . LYS A 1 359 ? 188.76200 351.47700 28.75600  1.000 65.08058  ? 394 LYS F NZ  1 
ATOM   2560 N N   . ILE A 1 360 ? 186.69000 357.32100 32.30000  1.000 34.61668  ? 395 ILE F N   1 
ATOM   2561 C CA  . ILE A 1 360 ? 185.90100 358.43900 31.80000  1.000 37.91686  ? 395 ILE F CA  1 
ATOM   2562 C C   . ILE A 1 360 ? 186.60400 359.11600 30.63300  1.000 40.89189  ? 395 ILE F C   1 
ATOM   2563 O O   . ILE A 1 360 ? 187.82600 359.04700 30.49000  1.000 35.10797  ? 395 ILE F O   1 
ATOM   2564 C CB  . ILE A 1 360 ? 185.58200 359.43300 32.94100  1.000 38.26095  ? 395 ILE F CB  1 
ATOM   2565 C CG1 . ILE A 1 360 ? 186.88900 360.01600 33.49400  1.000 37.48397  ? 395 ILE F CG1 1 
ATOM   2566 C CG2 . ILE A 1 360 ? 184.69300 358.80700 34.00400  1.000 35.15607  ? 395 ILE F CG2 1 
ATOM   2567 C CD1 . ILE A 1 360 ? 186.69800 361.21900 34.32100  1.000 38.18919  ? 395 ILE F CD1 1 
ATOM   2568 N N   . MET A 1 361 ? 185.84300 359.95300 29.92800  1.000 36.44194  ? 396 MET F N   1 
ATOM   2569 C CA  . MET A 1 361 ? 186.37700 360.85300 28.92000  1.000 35.75263  ? 396 MET F CA  1 
ATOM   2570 C C   . MET A 1 361 ? 185.85900 362.23400 29.25800  1.000 38.86155  ? 396 MET F C   1 
ATOM   2571 O O   . MET A 1 361 ? 184.79400 362.36600 29.87000  1.000 35.94856  ? 396 MET F O   1 
ATOM   2572 C CB  . MET A 1 361 ? 186.05000 360.42800 27.48800  1.000 41.09126  ? 396 MET F CB  1 
ATOM   2573 C CG  . MET A 1 361 ? 184.61500 360.33400 27.09800  1.000 44.59669  ? 396 MET F CG  1 
ATOM   2574 S SD  . MET A 1 361 ? 184.33100 361.78700 26.04400  1.000 69.15201  ? 396 MET F SD  1 
ATOM   2575 C CE  . MET A 1 361 ? 184.92000 361.06600 24.49900  1.000 55.17103  ? 396 MET F CE  1 
ATOM   2576 N N   . THR A 1 362 ? 186.66100 363.25400 28.95500  1.000 32.97840  ? 397 THR F N   1 
ATOM   2577 C CA  . THR A 1 362 ? 186.32900 364.61900 29.33500  1.000 37.44060  ? 397 THR F CA  1 
ATOM   2578 C C   . THR A 1 362 ? 186.23200 365.50700 28.10800  1.000 39.91057  ? 397 THR F C   1 
ATOM   2579 O O   . THR A 1 362 ? 186.60600 365.14500 26.99000  1.000 39.45061  ? 397 THR F O   1 
ATOM   2580 C CB  . THR A 1 362 ? 187.36400 365.20300 30.30200  1.000 35.88812  ? 397 THR F CB  1 
ATOM   2581 O OG1 . THR A 1 362 ? 188.65800 365.23600 29.66300  1.000 35.16296  ? 397 THR F OG1 1 
ATOM   2582 C CG2 . THR A 1 362 ? 187.44800 364.29100 31.55300  1.000 30.67217  ? 397 THR F CG2 1 
ATOM   2583 N N   . SER A 1 363 ? 185.50000 366.56100 28.26900  1.000 46.76041  ? 398 SER F N   1 
ATOM   2584 C CA  . SER A 1 363 ? 185.38800 367.47300 27.14000  1.000 54.35363  ? 398 SER F CA  1 
ATOM   2585 C C   . SER A 1 363 ? 184.70200 368.73700 27.60800  1.000 56.16804  ? 398 SER F C   1 
ATOM   2586 O O   . SER A 1 363 ? 184.61000 369.01700 28.81500  1.000 54.38927  ? 398 SER F O   1 
ATOM   2587 C CB  . SER A 1 363 ? 184.61200 366.85100 25.99200  1.000 43.59474  ? 398 SER F CB  1 
ATOM   2588 O OG  . SER A 1 363 ? 183.27500 366.80700 26.42500  1.000 52.20790  ? 398 SER F OG  1 
ATOM   2589 N N   . LYS A 1 364 ? 184.45100 369.58200 26.63000  1.000 50.47275  ? 399 LYS F N   1 
ATOM   2590 C CA  . LYS A 1 364 ? 183.62900 370.76100 26.76700  1.000 50.53413  ? 399 LYS F CA  1 
ATOM   2591 C C   . LYS A 1 364 ? 182.49300 370.73200 25.75000  1.000 59.01348  ? 399 LYS F C   1 
ATOM   2592 O O   . LYS A 1 364 ? 182.03100 371.79700 25.32400  1.000 64.27259  ? 399 LYS F O   1 
ATOM   2593 C CB  . LYS A 1 364 ? 184.40800 372.07300 26.73300  1.000 55.76861  ? 399 LYS F CB  1 
ATOM   2594 C CG  . LYS A 1 364 ? 185.38000 372.26400 27.89100  1.000 51.95312  ? 399 LYS F CG  1 
ATOM   2595 C CD  . LYS A 1 364 ? 186.16300 373.50500 27.61500  1.000 55.25819  ? 399 LYS F CD  1 
ATOM   2596 C CE  . LYS A 1 364 ? 186.32400 374.37700 28.86700  1.000 55.44768  ? 399 LYS F CE  1 
ATOM   2597 N NZ  . LYS A 1 364 ? 187.14800 373.78200 29.96500  1.000 67.70945  ? 399 LYS F NZ  1 
ATOM   2598 N N   . THR A 1 365 ? 181.99500 369.54600 25.33800  1.000 51.10178  ? 400 THR F N   1 
ATOM   2599 C CA  . THR A 1 365 ? 180.99100 369.57700 24.27200  1.000 60.24275  ? 400 THR F CA  1 
ATOM   2600 C C   . THR A 1 365 ? 179.60600 369.40100 24.87700  1.000 56.00548  ? 400 THR F C   1 
ATOM   2601 O O   . THR A 1 365 ? 179.05800 368.29300 24.95800  1.000 56.74730  ? 400 THR F O   1 
ATOM   2602 C CB  . THR A 1 365 ? 181.23600 368.52000 23.19200  1.000 68.82535  ? 400 THR F CB  1 
ATOM   2603 O OG1 . THR A 1 365 ? 182.54500 368.67400 22.63700  1.000 67.74400  ? 400 THR F OG1 1 
ATOM   2604 C CG2 . THR A 1 365 ? 180.19000 368.64700 22.03900  1.000 67.34490  ? 400 THR F CG2 1 
ATOM   2605 N N   . ASP A 1 366 ? 178.98100 370.55100 25.16700  1.000 49.81684  ? 401 ASP F N   1 
ATOM   2606 C CA  . ASP A 1 366 ? 177.65800 370.55900 25.76600  1.000 56.55357  ? 401 ASP F CA  1 
ATOM   2607 C C   . ASP A 1 366 ? 176.58000 370.71500 24.68000  1.000 59.96914  ? 401 ASP F C   1 
ATOM   2608 O O   . ASP A 1 366 ? 175.96600 371.77500 24.48600  1.000 56.02869  ? 401 ASP F O   1 
ATOM   2609 C CB  . ASP A 1 366 ? 177.56600 371.66800 26.80000  1.000 62.26019  ? 401 ASP F CB  1 
ATOM   2610 C CG  . ASP A 1 366 ? 178.00700 373.03200 26.24600  1.000 68.66055  ? 401 ASP F CG  1 
ATOM   2611 O OD1 . ASP A 1 366 ? 178.20900 373.17100 25.00200  1.000 64.73994  ? 401 ASP F OD1 1 
ATOM   2612 O OD2 . ASP A 1 366 ? 178.14100 373.96300 27.07200  1.000 71.96170  ? 401 ASP F OD2 1 
ATOM   2613 N N   . VAL A 1 367 ? 176.32200 369.61200 23.99100  1.000 57.07308  ? 402 VAL F N   1 
ATOM   2614 C CA  . VAL A 1 367 ? 175.25000 369.51100 23.01300  1.000 47.75653  ? 402 VAL F CA  1 
ATOM   2615 C C   . VAL A 1 367 ? 174.27500 368.59500 23.71800  1.000 40.21828  ? 402 VAL F C   1 
ATOM   2616 O O   . VAL A 1 367 ? 174.70700 367.69500 24.45000  1.000 36.52962  ? 402 VAL F O   1 
ATOM   2617 C CB  . VAL A 1 367 ? 175.65700 368.97800 21.61500  1.000 51.48427  ? 402 VAL F CB  1 
ATOM   2618 C CG1 . VAL A 1 367 ? 174.43900 368.85500 20.72700  1.000 40.89747  ? 402 VAL F CG1 1 
ATOM   2619 C CG2 . VAL A 1 367 ? 176.58500 369.97500 20.90000  1.000 45.24521  ? 402 VAL F CG2 1 
ATOM   2620 N N   . SER A 1 368 ? 172.99200 368.93200 23.65400  1.000 34.76067  ? 403 SER F N   1 
ATOM   2621 C CA  . SER A 1 368 ? 171.96600 368.15900 24.34300  1.000 29.22060  ? 403 SER F CA  1 
ATOM   2622 C C   . SER A 1 368 ? 171.77700 366.82800 23.63000  1.000 33.53316  ? 403 SER F C   1 
ATOM   2623 O O   . SER A 1 368 ? 171.90800 366.74600 22.41400  1.000 32.12997  ? 403 SER F O   1 
ATOM   2624 C CB  . SER A 1 368 ? 170.66000 368.94900 24.36000  1.000 25.57206  ? 403 SER F CB  1 
ATOM   2625 O OG  . SER A 1 368 ? 170.84000 370.14100 25.10400  1.000 31.96325  ? 403 SER F OG  1 
ATOM   2626 N N   . SER A 1 369 ? 171.41900 365.78900 24.38200  1.000 35.02163  ? 404 SER F N   1 
ATOM   2627 C CA  . SER A 1 369 ? 171.19100 364.48200 23.78400  1.000 34.90682  ? 404 SER F CA  1 
ATOM   2628 C C   . SER A 1 369 ? 170.38100 363.65000 24.75600  1.000 32.95865  ? 404 SER F C   1 
ATOM   2629 O O   . SER A 1 369 ? 170.25000 363.98400 25.92900  1.000 37.10037  ? 404 SER F O   1 
ATOM   2630 C CB  . SER A 1 369 ? 172.50300 363.79100 23.40500  1.000 38.71540  ? 404 SER F CB  1 
ATOM   2631 O OG  . SER A 1 369 ? 173.30500 363.62500 24.56500  1.000 38.70960  ? 404 SER F OG  1 
ATOM   2632 N N   . SER A 1 370 ? 169.90800 362.51300 24.26900  1.000 39.31685  ? 405 SER F N   1 
ATOM   2633 C CA  . SER A 1 370 ? 169.15800 361.58700 25.09300  1.000 37.57069  ? 405 SER F CA  1 
ATOM   2634 C C   . SER A 1 370 ? 169.56300 360.15600 24.75600  1.000 38.14872  ? 405 SER F C   1 
ATOM   2635 O O   . SER A 1 370 ? 169.98500 359.87100 23.63400  1.000 36.25513  ? 405 SER F O   1 
ATOM   2636 C CB  . SER A 1 370 ? 167.65900 361.75400 24.85500  1.000 35.90766  ? 405 SER F CB  1 
ATOM   2637 O OG  . SER A 1 370 ? 166.90500 360.85400 25.67100  1.000 38.15940  ? 405 SER F OG  1 
ATOM   2638 N N   . VAL A 1 371 ? 169.42400 359.26500 25.74300  1.000 32.37760  ? 406 VAL F N   1 
ATOM   2639 C CA  . VAL A 1 371 ? 169.70900 357.84800 25.56900  1.000 32.24369  ? 406 VAL F CA  1 
ATOM   2640 C C   . VAL A 1 371 ? 168.48200 357.09200 26.05600  1.000 29.44665  ? 406 VAL F C   1 
ATOM   2641 O O   . VAL A 1 371 ? 168.09000 357.23100 27.21800  1.000 32.06896  ? 406 VAL F O   1 
ATOM   2642 C CB  . VAL A 1 371 ? 170.95300 357.37200 26.35500  1.000 37.44813  ? 406 VAL F CB  1 
ATOM   2643 C CG1 . VAL A 1 371 ? 171.13600 355.85500 26.14200  1.000 34.61443  ? 406 VAL F CG1 1 
ATOM   2644 C CG2 . VAL A 1 371 ? 172.19900 358.10700 25.90000  1.000 39.49157  ? 406 VAL F CG2 1 
ATOM   2645 N N   . ILE A 1 372 ? 167.88900 356.29400 25.17000  1.000 29.55645  ? 407 ILE F N   1 
ATOM   2646 C CA  . ILE A 1 372 ? 166.75600 355.42900 25.48700  1.000 33.34898  ? 407 ILE F CA  1 
ATOM   2647 C C   . ILE A 1 372 ? 167.29200 354.16200 26.13900  1.000 34.42700  ? 407 ILE F C   1 
ATOM   2648 O O   . ILE A 1 372 ? 168.13200 353.48100 25.55000  1.000 34.85024  ? 407 ILE F O   1 
ATOM   2649 C CB  . ILE A 1 372 ? 165.95200 355.09000 24.22700  1.000 33.73359  ? 407 ILE F CB  1 
ATOM   2650 C CG1 . ILE A 1 372 ? 165.34600 356.37300 23.64300  1.000 36.54669  ? 407 ILE F CG1 1 
ATOM   2651 C CG2 . ILE A 1 372 ? 164.84600 354.09200 24.56700  1.000 37.88102  ? 407 ILE F CG2 1 
ATOM   2652 C CD1 . ILE A 1 372 ? 164.43300 357.09500 24.62100  1.000 34.72320  ? 407 ILE F CD1 1 
ATOM   2653 N N   . THR A 1 373 ? 166.92700 353.92800 27.39900  1.000 30.31105  ? 408 THR F N   1 
ATOM   2654 C CA  . THR A 1 373 ? 167.37700 352.76600 28.15100  1.000 35.59537  ? 408 THR F CA  1 
ATOM   2655 C C   . THR A 1 373 ? 166.36300 351.62300 28.06100  1.000 38.05648  ? 408 THR F C   1 
ATOM   2656 O O   . THR A 1 373 ? 165.46300 351.62400 27.21800  1.000 38.31509  ? 408 THR F O   1 
ATOM   2657 C CB  . THR A 1 373 ? 167.62700 353.15600 29.59900  1.000 35.26459  ? 408 THR F CB  1 
ATOM   2658 O OG1 . THR A 1 373 ? 166.36900 353.44400 30.20900  1.000 34.97819  ? 408 THR F OG1 1 
ATOM   2659 C CG2 . THR A 1 373 ? 168.54500 354.37900 29.67500  1.000 33.45609  ? 408 THR F CG2 1 
ATOM   2660 N N   . SER A 1 374 ? 166.53200 350.59500 28.90400  1.000 38.29665  ? 409 SER F N   1 
ATOM   2661 C CA  . SER A 1 374 ? 165.58900 349.47800 28.86000  1.000 38.88395  ? 409 SER F CA  1 
ATOM   2662 C C   . SER A 1 374 ? 164.26100 349.87400 29.48100  1.000 36.83820  ? 409 SER F C   1 
ATOM   2663 O O   . SER A 1 374 ? 163.21300 349.44300 29.00200  1.000 40.18945  ? 409 SER F O   1 
ATOM   2664 C CB  . SER A 1 374 ? 166.10300 348.23300 29.60500  1.000 38.18149  ? 409 SER F CB  1 
ATOM   2665 O OG  . SER A 1 374 ? 167.38300 347.79100 29.18200  1.000 48.50674  ? 409 SER F OG  1 
ATOM   2666 N N   . LEU A 1 375 ? 164.27400 350.74100 30.50400  1.000 35.59231  ? 410 LEU F N   1 
ATOM   2667 C CA  . LEU A 1 375 ? 163.03500 351.10000 31.18900  1.000 37.49049  ? 410 LEU F CA  1 
ATOM   2668 C C   . LEU A 1 375 ? 162.79400 352.60100 31.27200  1.000 36.52660  ? 410 LEU F C   1 
ATOM   2669 O O   . LEU A 1 375 ? 161.91500 353.01900 32.01800  1.000 39.62966  ? 410 LEU F O   1 
ATOM   2670 C CB  . LEU A 1 375 ? 163.03200 350.53700 32.61300  1.000 31.50823  ? 410 LEU F CB  1 
ATOM   2671 C CG  . LEU A 1 375 ? 163.12800 349.01500 32.72000  1.000 41.48272  ? 410 LEU F CG  1 
ATOM   2672 C CD1 . LEU A 1 375 ? 163.21400 348.57700 34.17800  1.000 35.98118  ? 410 LEU F CD1 1 
ATOM   2673 C CD2 . LEU A 1 375 ? 161.99800 348.36700 32.00600  1.000 44.47325  ? 410 LEU F CD2 1 
ATOM   2674 N N   . GLY A 1 376 ? 163.48200 353.41900 30.48000  1.000 36.74243  ? 411 GLY F N   1 
ATOM   2675 C CA  . GLY A 1 376 ? 163.28100 354.85000 30.59200  1.000 32.07704  ? 411 GLY F CA  1 
ATOM   2676 C C   . GLY A 1 376 ? 164.15200 355.64600 29.64100  1.000 34.27873  ? 411 GLY F C   1 
ATOM   2677 O O   . GLY A 1 376 ? 164.36400 355.22600 28.50800  1.000 31.87308  ? 411 GLY F O   1 
ATOM   2678 N N   . ALA A 1 377 ? 164.62300 356.81500 30.06400  1.000 32.24287  ? 412 ALA F N   1 
ATOM   2679 C CA  . ALA A 1 377 ? 165.42000 357.65800 29.18400  1.000 30.93623  ? 412 ALA F CA  1 
ATOM   2680 C C   . ALA A 1 377 ? 166.26500 358.59100 30.01300  1.000 31.27491  ? 412 ALA F C   1 
ATOM   2681 O O   . ALA A 1 377 ? 165.79300 359.11600 31.03000  1.000 32.61723  ? 412 ALA F O   1 
ATOM   2682 C CB  . ALA A 1 377 ? 164.55200 358.48800 28.25800  1.000 30.11044  ? 412 ALA F CB  1 
ATOM   2683 N N   . ILE A 1 378 ? 167.54100 358.65700 29.66500  1.000 31.34057  ? 413 ILE F N   1 
ATOM   2684 C CA  . ILE A 1 378 ? 168.46300 359.64600 30.19700  1.000 31.16550  ? 413 ILE F CA  1 
ATOM   2685 C C   . ILE A 1 378 ? 168.42900 360.83800 29.26800  1.000 30.09036  ? 413 ILE F C   1 
ATOM   2686 O O   . ILE A 1 378 ? 168.39000 360.67000 28.05100  1.000 33.27093  ? 413 ILE F O   1 
ATOM   2687 C CB  . ILE A 1 378 ? 169.89600 359.09000 30.29600  1.000 33.61065  ? 413 ILE F CB  1 
ATOM   2688 C CG1 . ILE A 1 378 ? 169.93900 357.73900 31.03300  1.000 32.01073  ? 413 ILE F CG1 1 
ATOM   2689 C CG2 . ILE A 1 378 ? 170.87300 360.14700 30.86200  1.000 27.75057  ? 413 ILE F CG2 1 
ATOM   2690 C CD1 . ILE A 1 378 ? 171.32400 357.16400 31.03300  1.000 29.03850  ? 413 ILE F CD1 1 
ATOM   2691 N N   . VAL A 1 379 ? 168.39900 362.03800 29.82700  1.000 31.85234  ? 414 VAL F N   1 
ATOM   2692 C CA  . VAL A 1 379 ? 168.37500 363.27500 29.05800  1.000 31.02829  ? 414 VAL F CA  1 
ATOM   2693 C C   . VAL A 1 379 ? 169.48200 364.16100 29.59400  1.000 29.54154  ? 414 VAL F C   1 
ATOM   2694 O O   . VAL A 1 379 ? 169.50900 364.45900 30.79300  1.000 30.83798  ? 414 VAL F O   1 
ATOM   2695 C CB  . VAL A 1 379 ? 167.01900 364.00000 29.09700  1.000 29.19782  ? 414 VAL F CB  1 
ATOM   2696 C CG1 . VAL A 1 379 ? 167.16900 365.34400 28.39600  1.000 26.49296  ? 414 VAL F CG1 1 
ATOM   2697 C CG2 . VAL A 1 379 ? 166.00200 363.15800 28.31500  1.000 30.14785  ? 414 VAL F CG2 1 
ATOM   2698 N N   . SER A 1 380 ? 170.39700 364.55800 28.72800  1.000 29.00561  ? 415 SER F N   1 
ATOM   2699 C CA  . SER A 1 380 ? 171.42900 365.53100 29.04600  1.000 33.41297  ? 415 SER F CA  1 
ATOM   2700 C C   . SER A 1 380 ? 171.00700 366.80400 28.32600  1.000 28.78861  ? 415 SER F C   1 
ATOM   2701 O O   . SER A 1 380 ? 171.09900 366.87000 27.10300  1.000 27.68900  ? 415 SER F O   1 
ATOM   2702 C CB  . SER A 1 380 ? 172.82600 365.08700 28.58100  1.000 33.68382  ? 415 SER F CB  1 
ATOM   2703 O OG  . SER A 1 380 ? 173.24900 363.90200 29.20800  1.000 34.77250  ? 415 SER F OG  1 
ATOM   2704 N N   . CYS A 1 381 ? 170.52500 367.79900 29.07400  1.000 30.62275  ? 416 CYS F N   1 
ATOM   2705 C CA  . CYS A 1 381 ? 169.99000 369.03700 28.51000  1.000 29.40166  ? 416 CYS F CA  1 
ATOM   2706 C C   . CYS A 1 381 ? 170.95500 370.17000 28.80900  1.000 29.92331  ? 416 CYS F C   1 
ATOM   2707 O O   . CYS A 1 381 ? 171.20000 370.47100 29.97300  1.000 32.41336  ? 416 CYS F O   1 
ATOM   2708 C CB  . CYS A 1 381 ? 168.62500 369.37200 29.12800  1.000 32.72830  ? 416 CYS F CB  1 
ATOM   2709 S SG  . CYS A 1 381 ? 167.55200 370.41900 28.10900  1.000 40.11399  ? 416 CYS F SG  1 
ATOM   2710 N N   . TYR A 1 382 ? 171.38400 370.88700 27.76300  1.000 28.09714  ? 417 TYR F N   1 
ATOM   2711 C CA  . TYR A 1 382 ? 172.34600 371.96200 27.92900  1.000 33.05502  ? 417 TYR F CA  1 
ATOM   2712 C C   . TYR A 1 382 ? 172.02900 373.11400 26.99500  1.000 30.00669  ? 417 TYR F C   1 
ATOM   2713 O O   . TYR A 1 382 ? 171.24300 372.98000 26.06200  1.000 30.98271  ? 417 TYR F O   1 
ATOM   2714 C CB  . TYR A 1 382 ? 173.82300 371.51300 27.71300  1.000 36.42271  ? 417 TYR F CB  1 
ATOM   2715 C CG  . TYR A 1 382 ? 174.16100 370.33200 28.58000  1.000 37.82949  ? 417 TYR F CG  1 
ATOM   2716 C CD1 . TYR A 1 382 ? 174.31200 370.51000 29.95300  1.000 33.72451  ? 417 TYR F CD1 1 
ATOM   2717 C CD2 . TYR A 1 382 ? 174.45400 369.07300 28.03700  1.000 34.74960  ? 417 TYR F CD2 1 
ATOM   2718 C CE1 . TYR A 1 382 ? 174.63300 369.45800 30.78600  1.000 33.01308  ? 417 TYR F CE1 1 
ATOM   2719 C CE2 . TYR A 1 382 ? 174.79200 367.99900 28.87300  1.000 32.99582  ? 417 TYR F CE2 1 
ATOM   2720 C CZ  . TYR A 1 382 ? 174.87700 368.21500 30.25300  1.000 35.28603  ? 417 TYR F CZ  1 
ATOM   2721 O OH  . TYR A 1 382 ? 175.20500 367.21000 31.13600  1.000 33.40273  ? 417 TYR F OH  1 
ATOM   2722 N N   . GLY A 1 383 ? 172.43500 374.29100 27.41900  1.000 34.47339  ? 418 GLY F N   1 
ATOM   2723 C CA  . GLY A 1 383 ? 172.21400 375.43700 26.57700  1.000 34.16511  ? 418 GLY F CA  1 
ATOM   2724 C C   . GLY A 1 383 ? 170.74500 375.81300 26.63800  1.000 33.92096  ? 418 GLY F C   1 
ATOM   2725 O O   . GLY A 1 383 ? 170.09500 375.74900 27.68300  1.000 35.41951  ? 418 GLY F O   1 
ATOM   2726 N N   . LYS A 1 384 ? 170.22100 376.19800 25.48700  1.000 32.11638  ? 419 LYS F N   1 
ATOM   2727 C CA  . LYS A 1 384 ? 168.82800 376.58700 25.28700  1.000 38.64182  ? 419 LYS F CA  1 
ATOM   2728 C C   . LYS A 1 384 ? 167.92700 375.47200 24.79700  1.000 36.70921  ? 419 LYS F C   1 
ATOM   2729 O O   . LYS A 1 384 ? 166.80100 375.75500 24.39800  1.000 39.23945  ? 419 LYS F O   1 
ATOM   2730 C CB  . LYS A 1 384 ? 168.72900 377.80100 24.36500  1.000 37.68463  ? 419 LYS F CB  1 
ATOM   2731 C CG  . LYS A 1 384 ? 169.73800 378.89600 24.70100  1.000 37.41684  ? 419 LYS F CG  1 
ATOM   2732 C CD  . LYS A 1 384 ? 169.30100 380.14000 23.93000  1.000 38.68414  ? 419 LYS F CD  1 
ATOM   2733 C CE  . LYS A 1 384 ? 170.27200 381.25700 24.08800  1.000 41.20147  ? 419 LYS F CE  1 
ATOM   2734 N NZ  . LYS A 1 384 ? 169.74900 381.90700 25.36500  1.000 40.74818  ? 419 LYS F NZ  1 
ATOM   2735 N N   . THR A 1 385 ? 168.36700 374.22500 24.85300  1.000 33.48108  ? 420 THR F N   1 
ATOM   2736 C CA  . THR A 1 385 ? 167.60000 373.13400 24.27800  1.000 32.32456  ? 420 THR F CA  1 
ATOM   2737 C C   . THR A 1 385 ? 166.34000 372.89000 25.08000  1.000 31.31512  ? 420 THR F C   1 
ATOM   2738 O O   . THR A 1 385 ? 166.33300 372.94200 26.31100  1.000 27.60413  ? 420 THR F O   1 
ATOM   2739 C CB  . THR A 1 385 ? 168.43500 371.86300 24.23800  1.000 32.41640  ? 420 THR F CB  1 
ATOM   2740 O OG1 . THR A 1 385 ? 169.70100 372.19200 23.65900  1.000 28.99249  ? 420 THR F OG1 1 
ATOM   2741 C CG2 . THR A 1 385 ? 167.72100 370.81400 23.40800  1.000 29.10616  ? 420 THR F CG2 1 
ATOM   2742 N N   . LYS A 1 386 ? 165.27400 372.61200 24.35200  1.000 34.46058  ? 421 LYS F N   1 
ATOM   2743 C CA  . LYS A 1 386 ? 163.95100 372.35500 24.88900  1.000 34.44085  ? 421 LYS F CA  1 
ATOM   2744 C C   . LYS A 1 386 ? 163.81900 370.84800 25.07300  1.000 29.98052  ? 421 LYS F C   1 
ATOM   2745 O O   . LYS A 1 386 ? 163.88900 370.10300 24.10700  1.000 32.39305  ? 421 LYS F O   1 
ATOM   2746 C CB  . LYS A 1 386 ? 162.89900 372.87800 23.92700  1.000 31.57731  ? 421 LYS F CB  1 
ATOM   2747 C CG  . LYS A 1 386 ? 161.44900 372.62000 24.36300  1.000 40.00757  ? 421 LYS F CG  1 
ATOM   2748 C CD  . LYS A 1 386 ? 160.50400 373.16200 23.26200  1.000 44.35910  ? 421 LYS F CD  1 
ATOM   2749 C CE  . LYS A 1 386 ? 159.00600 373.00400 23.54900  1.000 45.14359  ? 421 LYS F CE  1 
ATOM   2750 N NZ  . LYS A 1 386 ? 158.46500 371.74300 24.09300  1.000 53.83156  ? 421 LYS F NZ  1 
ATOM   2751 N N   . CYS A 1 387 ? 164.00600 370.38700 26.29400  1.000 30.83693  ? 422 CYS F N   1 
ATOM   2752 C CA  . CYS A 1 387 ? 163.86500 368.97600 26.63000  1.000 30.21300  ? 422 CYS F CA  1 
ATOM   2753 C C   . CYS A 1 387 ? 162.60300 368.71000 27.43800  1.000 31.20698  ? 422 CYS F C   1 
ATOM   2754 O O   . CYS A 1 387 ? 162.52200 369.18200 28.56700  1.000 31.95195  ? 422 CYS F O   1 
ATOM   2755 C CB  . CYS A 1 387 ? 165.11500 368.53800 27.39700  1.000 30.04734  ? 422 CYS F CB  1 
ATOM   2756 S SG  . CYS A 1 387 ? 166.67500 369.13800 26.59900  1.000 34.52925  ? 422 CYS F SG  1 
ATOM   2757 N N   . THR A 1 388 ? 161.83100 367.69500 27.06100  1.000 27.99131  ? 423 THR F N   1 
ATOM   2758 C CA  . THR A 1 388 ? 160.56000 367.45400 27.72600  1.000 29.53278  ? 423 THR F CA  1 
ATOM   2759 C C   . THR A 1 388 ? 160.23800 365.97000 27.57400  1.000 31.34271  ? 423 THR F C   1 
ATOM   2760 O O   . THR A 1 388 ? 160.80500 365.27700 26.74200  1.000 33.46822  ? 423 THR F O   1 
ATOM   2761 C CB  . THR A 1 388 ? 159.39800 368.29500 27.14000  1.000 31.44755  ? 423 THR F CB  1 
ATOM   2762 O OG1 . THR A 1 388 ? 159.14800 367.88400 25.79800  1.000 34.83155  ? 423 THR F OG1 1 
ATOM   2763 C CG2 . THR A 1 388 ? 159.69800 369.81900 27.14900  1.000 27.46685  ? 423 THR F CG2 1 
ATOM   2764 N N   . ALA A 1 389 ? 159.30300 365.50200 28.38800  1.000 31.50898  ? 424 ALA F N   1 
ATOM   2765 C CA  . ALA A 1 389 ? 158.79300 364.14700 28.38600  1.000 31.59020  ? 424 ALA F CA  1 
ATOM   2766 C C   . ALA A 1 389 ? 157.28700 364.20300 28.42200  1.000 31.02875  ? 424 ALA F C   1 
ATOM   2767 O O   . ALA A 1 389 ? 156.71100 364.98100 29.19100  1.000 32.84596  ? 424 ALA F O   1 
ATOM   2768 C CB  . ALA A 1 389 ? 159.32600 363.33800 29.57600  1.000 31.47377  ? 424 ALA F CB  1 
ATOM   2769 N N   . SER A 1 390 ? 156.68400 363.53900 27.46000  1.000 31.16573  ? 425 SER F N   1 
ATOM   2770 C CA  . SER A 1 390 ? 155.25600 363.57100 27.22800  1.000 41.78175  ? 425 SER F CA  1 
ATOM   2771 C C   . SER A 1 390 ? 154.58500 362.20600 27.28100  1.000 46.36911  ? 425 SER F C   1 
ATOM   2772 O O   . SER A 1 390 ? 155.19900 361.13400 27.12200  1.000 43.69001  ? 425 SER F O   1 
ATOM   2773 C CB  . SER A 1 390 ? 154.90000 364.21300 25.88200  1.000 36.49747  ? 425 SER F CB  1 
ATOM   2774 O OG  . SER A 1 390 ? 155.44900 365.50800 25.79100  1.000 44.70875  ? 425 SER F OG  1 
ATOM   2775 N N   . ASN A 1 391 ? 153.30100 362.31700 27.55400  1.000 48.16005  ? 426 ASN F N   1 
ATOM   2776 C CA  . ASN A 1 391 ? 152.32800 361.25800 27.45700  1.000 49.27095  ? 426 ASN F CA  1 
ATOM   2777 C C   . ASN A 1 391 ? 151.49100 361.55000 26.21500  1.000 56.64714  ? 426 ASN F C   1 
ATOM   2778 O O   . ASN A 1 391 ? 151.19300 362.70800 25.91200  1.000 54.79605  ? 426 ASN F O   1 
ATOM   2779 C CB  . ASN A 1 391 ? 151.43100 361.21600 28.65700  1.000 54.92029  ? 426 ASN F CB  1 
ATOM   2780 C CG  . ASN A 1 391 ? 150.49700 360.10200 28.56800  1.000 58.81184  ? 426 ASN F CG  1 
ATOM   2781 O OD1 . ASN A 1 391 ? 149.43500 360.25100 27.97300  1.000 60.78721  ? 426 ASN F OD1 1 
ATOM   2782 N ND2 . ASN A 1 391 ? 150.83300 358.98300 29.19700  1.000 59.63603  ? 426 ASN F ND2 1 
ATOM   2783 N N   . LYS A 1 392 ? 151.06700 360.49200 25.52600  1.000 61.31472  ? 427 LYS F N   1 
ATOM   2784 C CA  . LYS A 1 392 ? 150.43300 360.63700 24.21300  1.000 59.72913  ? 427 LYS F CA  1 
ATOM   2785 C C   . LYS A 1 392 ? 149.16500 361.48600 24.25600  1.000 63.90575  ? 427 LYS F C   1 
ATOM   2786 O O   . LYS A 1 392 ? 148.89200 362.25200 23.32600  1.000 72.76753  ? 427 LYS F O   1 
ATOM   2787 C CB  . LYS A 1 392 ? 150.10500 359.22100 23.72600  1.000 69.93114  ? 427 LYS F CB  1 
ATOM   2788 C CG  . LYS A 1 392 ? 149.71700 358.93700 22.27800  1.000 73.41384  ? 427 LYS F CG  1 
ATOM   2789 C CD  . LYS A 1 392 ? 148.65400 357.82400 22.36300  1.000 75.40929  ? 427 LYS F CD  1 
ATOM   2790 C CE  . LYS A 1 392 ? 148.65800 356.83500 21.21400  1.000 78.21178  ? 427 LYS F CE  1 
ATOM   2791 N NZ  . LYS A 1 392 ? 149.06100 357.41600 19.91300  1.000 80.35801  ? 427 LYS F NZ  1 
ATOM   2792 N N   . ASN A 1 393 ? 148.39100 361.38200 25.32900  1.000 60.79335  ? 428 ASN F N   1 
ATOM   2793 C CA  . ASN A 1 393 ? 147.12000 362.08400 25.46700  1.000 65.09197  ? 428 ASN F CA  1 
ATOM   2794 C C   . ASN A 1 393 ? 147.12500 363.25500 26.43400  1.000 61.78526  ? 428 ASN F C   1 
ATOM   2795 O O   . ASN A 1 393 ? 146.26000 364.12400 26.32600  1.000 63.35127  ? 428 ASN F O   1 
ATOM   2796 C CB  . ASN A 1 393 ? 145.99900 361.12200 25.88200  1.000 68.53286  ? 428 ASN F CB  1 
ATOM   2797 C CG  . ASN A 1 393 ? 145.89500 359.90400 24.97900  1.000 73.02395  ? 428 ASN F CG  1 
ATOM   2798 O OD1 . ASN A 1 393 ? 145.94700 360.01800 23.75500  1.000 74.47132  ? 428 ASN F OD1 1 
ATOM   2799 N ND2 . ASN A 1 393 ? 145.78000 358.72400 25.58800  1.000 78.11949  ? 428 ASN F ND2 1 
ATOM   2800 N N   . ARG A 1 394 ? 148.06800 363.31900 27.34800  1.000 53.85694  ? 429 ARG F N   1 
ATOM   2801 C CA  . ARG A 1 394 ? 148.12400 364.41400 28.29800  1.000 51.14462  ? 429 ARG F CA  1 
ATOM   2802 C C   . ARG A 1 394 ? 149.02700 365.55600 27.85400  1.000 49.63230  ? 429 ARG F C   1 
ATOM   2803 O O   . ARG A 1 394 ? 148.87700 366.67000 28.35700  1.000 51.13941  ? 429 ARG F O   1 
ATOM   2804 C CB  . ARG A 1 394 ? 148.56200 363.87900 29.66300  1.000 50.82070  ? 429 ARG F CB  1 
ATOM   2805 C CG  . ARG A 1 394 ? 147.95900 362.50400 30.04100  1.000 58.34028  ? 429 ARG F CG  1 
ATOM   2806 C CD  . ARG A 1 394 ? 147.89300 362.31400 31.55100  1.000 58.41304  ? 429 ARG F CD  1 
ATOM   2807 N NE  . ARG A 1 394 ? 148.28900 360.96900 31.97300  1.000 67.86817  ? 429 ARG F NE  1 
ATOM   2808 C CZ  . ARG A 1 394 ? 147.75400 359.82900 31.54600  1.000 68.22137  ? 429 ARG F CZ  1 
ATOM   2809 N NH1 . ARG A 1 394 ? 146.69600 359.81200 30.74500  1.000 68.14859  ? 429 ARG F NH1 1 
ATOM   2810 N NH2 . ARG A 1 394 ? 148.27000 358.67600 31.96700  1.000 68.64355  ? 429 ARG F NH2 1 
ATOM   2811 N N   . GLY A 1 395 ? 149.97200 365.31600 26.96500  1.000 47.73720  ? 430 GLY F N   1 
ATOM   2812 C CA  . GLY A 1 395 ? 150.88600 366.36600 26.58300  1.000 41.96023  ? 430 GLY F CA  1 
ATOM   2813 C C   . GLY A 1 395 ? 152.14400 366.31500 27.42300  1.000 40.70887  ? 430 GLY F C   1 
ATOM   2814 O O   . GLY A 1 395 ? 152.52100 365.25800 27.93900  1.000 40.33855  ? 430 GLY F O   1 
ATOM   2815 N N   . ILE A 1 396 ? 152.79000 367.46000 27.59700  1.000 41.83146  ? 431 ILE F N   1 
ATOM   2816 C CA  . ILE A 1 396 ? 154.03200 367.52200 28.34700  1.000 32.36007  ? 431 ILE F CA  1 
ATOM   2817 C C   . ILE A 1 396 ? 153.78300 367.27100 29.82400  1.000 36.28897  ? 431 ILE F C   1 
ATOM   2818 O O   . ILE A 1 396 ? 153.01000 367.98900 30.46500  1.000 39.90818  ? 431 ILE F O   1 
ATOM   2819 C CB  . ILE A 1 396 ? 154.71000 368.86900 28.12200  1.000 30.46248  ? 431 ILE F CB  1 
ATOM   2820 C CG1 . ILE A 1 396 ? 155.19500 368.95200 26.68100  1.000 34.25898  ? 431 ILE F CG1 1 
ATOM   2821 C CG2 . ILE A 1 396 ? 155.88900 369.03300 29.09600  1.000 32.93884  ? 431 ILE F CG2 1 
ATOM   2822 C CD1 . ILE A 1 396 ? 155.76000 370.29600 26.33600  1.000 36.86891  ? 431 ILE F CD1 1 
ATOM   2823 N N   . ILE A 1 397 ? 154.39100 366.21500 30.36200  1.000 33.20487  ? 432 ILE F N   1 
ATOM   2824 C CA  . ILE A 1 397 ? 154.27100 365.88900 31.78200  1.000 33.84535  ? 432 ILE F CA  1 
ATOM   2825 C C   . ILE A 1 397 ? 155.56100 366.15900 32.56300  1.000 32.07518  ? 432 ILE F C   1 
ATOM   2826 O O   . ILE A 1 397 ? 155.51900 366.23700 33.79600  1.000 31.83658  ? 432 ILE F O   1 
ATOM   2827 C CB  . ILE A 1 397 ? 153.79900 364.43500 32.00800  1.000 46.29221  ? 432 ILE F CB  1 
ATOM   2828 C CG1 . ILE A 1 397 ? 154.75100 363.46600 31.33700  1.000 42.29755  ? 432 ILE F CG1 1 
ATOM   2829 C CG2 . ILE A 1 397 ? 152.38900 364.21900 31.40200  1.000 37.74316  ? 432 ILE F CG2 1 
ATOM   2830 C CD1 . ILE A 1 397 ? 155.72000 362.90800 32.30700  1.000 49.46703  ? 432 ILE F CD1 1 
ATOM   2831 N N   . LYS A 1 398 ? 156.68100 366.39100 31.88900  1.000 36.21243  ? 433 LYS F N   1 
ATOM   2832 C CA  . LYS A 1 398 ? 157.94100 366.70600 32.55000  1.000 33.35624  ? 433 LYS F CA  1 
ATOM   2833 C C   . LYS A 1 398 ? 158.83000 367.54500 31.66100  1.000 30.37695  ? 433 LYS F C   1 
ATOM   2834 O O   . LYS A 1 398 ? 158.91500 367.29900 30.46100  1.000 32.22996  ? 433 LYS F O   1 
ATOM   2835 C CB  . LYS A 1 398 ? 158.73600 365.43200 32.88100  1.000 36.10386  ? 433 LYS F CB  1 
ATOM   2836 C CG  . LYS A 1 398 ? 160.10500 365.75000 33.54600  1.000 35.12393  ? 433 LYS F CG  1 
ATOM   2837 C CD  . LYS A 1 398 ? 160.80200 364.51100 34.14100  1.000 43.89510  ? 433 LYS F CD  1 
ATOM   2838 C CE  . LYS A 1 398 ? 162.04000 364.90800 34.90500  1.000 42.64401  ? 433 LYS F CE  1 
ATOM   2839 N NZ  . LYS A 1 398 ? 161.89700 364.82700 36.35200  1.000 44.77722  ? 433 LYS F NZ  1 
ATOM   2840 N N   . THR A 1 399 ? 159.36300 368.60300 32.22500  1.000 27.42417  ? 434 THR F N   1 
ATOM   2841 C CA  . THR A 1 399 ? 160.33300 369.45900 31.56900  1.000 28.91285  ? 434 THR F CA  1 
ATOM   2842 C C   . THR A 1 399 ? 161.68400 369.31600 32.25100  1.000 34.16230  ? 434 THR F C   1 
ATOM   2843 O O   . THR A 1 399 ? 161.78100 369.53500 33.46400  1.000 31.20262  ? 434 THR F O   1 
ATOM   2844 C CB  . THR A 1 399 ? 159.88600 370.91400 31.61900  1.000 30.07440  ? 434 THR F CB  1 
ATOM   2845 O OG1 . THR A 1 399 ? 158.57700 371.01500 31.06400  1.000 28.76092  ? 434 THR F OG1 1 
ATOM   2846 C CG2 . THR A 1 399 ? 160.84100 371.78600 30.79300  1.000 28.77491  ? 434 THR F CG2 1 
ATOM   2847 N N   . PHE A 1 400 ? 162.71400 368.92600 31.49800  1.000 31.17450  ? 435 PHE F N   1 
ATOM   2848 C CA  . PHE A 1 400 ? 164.03500 368.73900 32.09700  1.000 36.44250  ? 435 PHE F CA  1 
ATOM   2849 C C   . PHE A 1 400 ? 164.76500 370.06800 32.28900  1.000 34.34659  ? 435 PHE F C   1 
ATOM   2850 O O   . PHE A 1 400 ? 164.76600 370.92500 31.39700  1.000 41.27173  ? 435 PHE F O   1 
ATOM   2851 C CB  . PHE A 1 400 ? 164.90200 367.81100 31.22600  1.000 29.66564  ? 435 PHE F CB  1 
ATOM   2852 C CG  . PHE A 1 400 ? 164.32200 366.43900 31.01500  1.000 31.08370  ? 435 PHE F CG  1 
ATOM   2853 C CD1 . PHE A 1 400 ? 164.54000 365.44200 31.95000  1.000 34.73910  ? 435 PHE F CD1 1 
ATOM   2854 C CD2 . PHE A 1 400 ? 163.52000 366.15300 29.92400  1.000 29.41027  ? 435 PHE F CD2 1 
ATOM   2855 C CE1 . PHE A 1 400 ? 164.01300 364.15600 31.76700  1.000 30.83566  ? 435 PHE F CE1 1 
ATOM   2856 C CE2 . PHE A 1 400 ? 162.96900 364.88700 29.74800  1.000 30.21309  ? 435 PHE F CE2 1 
ATOM   2857 C CZ  . PHE A 1 400 ? 163.23800 363.88700 30.67000  1.000 35.79399  ? 435 PHE F CZ  1 
ATOM   2858 N N   . SER A 1 401 ? 165.46400 370.22000 33.41700  1.000 37.77176  ? 436 SER F N   1 
ATOM   2859 C CA  . SER A 1 401 ? 166.28700 371.42700 33.48800  1.000 40.96144  ? 436 SER F CA  1 
ATOM   2860 C C   . SER A 1 401 ? 167.68700 371.07200 32.97600  1.000 38.43258  ? 436 SER F C   1 
ATOM   2861 O O   . SER A 1 401 ? 168.01500 369.89600 32.75400  1.000 36.10336  ? 436 SER F O   1 
ATOM   2862 C CB  . SER A 1 401 ? 166.37200 372.00900 34.91200  1.000 43.83461  ? 436 SER F CB  1 
ATOM   2863 O OG  . SER A 1 401 ? 165.10800 372.01900 35.59000  1.000 58.56483  ? 436 SER F OG  1 
ATOM   2864 N N   . ASN A 1 402 ? 168.57100 372.06600 33.00300  1.000 35.91897  ? 437 ASN F N   1 
ATOM   2865 C CA  . ASN A 1 402 ? 169.93100 371.90000 32.52700  1.000 41.73919  ? 437 ASN F CA  1 
ATOM   2866 C C   . ASN A 1 402 ? 170.66900 370.94600 33.44300  1.000 39.23262  ? 437 ASN F C   1 
ATOM   2867 O O   . ASN A 1 402 ? 170.48800 370.98200 34.66000  1.000 36.94543  ? 437 ASN F O   1 
ATOM   2868 C CB  . ASN A 1 402 ? 170.65800 373.24700 32.41600  1.000 40.01944  ? 437 ASN F CB  1 
ATOM   2869 C CG  . ASN A 1 402 ? 170.41500 373.90900 31.08300  1.000 43.67227  ? 437 ASN F CG  1 
ATOM   2870 O OD1 . ASN A 1 402 ? 169.53400 373.49300 30.31400  1.000 44.09009  ? 437 ASN F OD1 1 
ATOM   2871 N ND2 . ASN A 1 402 ? 171.19700 374.92300 30.77700  1.000 50.54147  ? 437 ASN F ND2 1 
ATOM   2872 N N   . GLY A 1 403 ? 171.32700 369.96500 32.83700  1.000 35.50515  ? 438 GLY F N   1 
ATOM   2873 C CA  . GLY A 1 403 ? 172.02800 368.93900 33.56600  1.000 37.41748  ? 438 GLY F CA  1 
ATOM   2874 C C   . GLY A 1 403 ? 171.63200 367.60900 33.02100  1.000 33.37337  ? 438 GLY F C   1 
ATOM   2875 O O   . GLY A 1 403 ? 171.05800 367.50000 31.92900  1.000 32.24183  ? 438 GLY F O   1 
ATOM   2876 N N   . CYS A 1 404 ? 171.96600 366.56400 33.75700  1.000 33.07971  ? 439 CYS F N   1 
ATOM   2877 C CA  . CYS A 1 404 ? 171.63000 365.22300 33.32500  1.000 31.18706  ? 439 CYS F CA  1 
ATOM   2878 C C   . CYS A 1 404 ? 170.51800 364.72300 34.22800  1.000 35.90469  ? 439 CYS F C   1 
ATOM   2879 O O   . CYS A 1 404 ? 170.64400 364.76700 35.46000  1.000 33.78501  ? 439 CYS F O   1 
ATOM   2880 C CB  . CYS A 1 404 ? 172.87300 364.33200 33.37100  1.000 32.51357  ? 439 CYS F CB  1 
ATOM   2881 S SG  . CYS A 1 404 ? 172.50200 362.60200 32.99600  1.000 38.56492  ? 439 CYS F SG  1 
ATOM   2882 N N   . ASP A 1 405 ? 169.45200 364.20600 33.62000  1.000 33.49744  ? 440 ASP F N   1 
ATOM   2883 C CA  . ASP A 1 405 ? 168.30300 363.75100 34.37700  1.000 32.68533  ? 440 ASP F CA  1 
ATOM   2884 C C   . ASP A 1 405 ? 167.77600 362.46200 33.74500  1.000 32.75768  ? 440 ASP F C   1 
ATOM   2885 O O   . ASP A 1 405 ? 168.25300 362.01000 32.70000  1.000 32.04632  ? 440 ASP F O   1 
ATOM   2886 C CB  . ASP A 1 405 ? 167.21800 364.84600 34.32400  1.000 35.75950  ? 440 ASP F CB  1 
ATOM   2887 C CG  . ASP A 1 405 ? 166.30200 364.88300 35.56600  1.000 38.87993  ? 440 ASP F CG  1 
ATOM   2888 O OD1 . ASP A 1 405 ? 166.23200 363.92100 36.37300  1.000 39.20133  ? 440 ASP F OD1 1 
ATOM   2889 O OD2 . ASP A 1 405 ? 165.52000 365.85600 35.62800  1.000 44.41567  ? 440 ASP F OD2 1 
ATOM   2890 N N   . TYR A 1 406 ? 166.69300 361.93600 34.30200  1.000 32.50474  ? 441 TYR F N   1 
ATOM   2891 C CA  . TYR A 1 406 ? 166.15300 360.65800 33.84900  1.000 32.60282  ? 441 TYR F CA  1 
ATOM   2892 C C   . TYR A 1 406 ? 164.65000 360.55300 34.07300  1.000 34.22433  ? 441 TYR F C   1 
ATOM   2893 O O   . TYR A 1 406 ? 164.10900 361.18700 34.97000  1.000 34.44005  ? 441 TYR F O   1 
ATOM   2894 C CB  . TYR A 1 406 ? 166.83200 359.54900 34.64600  1.000 34.50319  ? 441 TYR F CB  1 
ATOM   2895 C CG  . TYR A 1 406 ? 166.29500 358.14000 34.48900  1.000 32.71492  ? 441 TYR F CG  1 
ATOM   2896 C CD1 . TYR A 1 406 ? 166.73300 357.29300 33.46600  1.000 33.90555  ? 441 TYR F CD1 1 
ATOM   2897 C CD2 . TYR A 1 406 ? 165.34100 357.65600 35.39000  1.000 34.60528  ? 441 TYR F CD2 1 
ATOM   2898 C CE1 . TYR A 1 406 ? 166.24000 355.98500 33.36500  1.000 33.22454  ? 441 TYR F CE1 1 
ATOM   2899 C CE2 . TYR A 1 406 ? 164.82500 356.38200 35.28800  1.000 35.24769  ? 441 TYR F CE2 1 
ATOM   2900 C CZ  . TYR A 1 406 ? 165.27700 355.54600 34.27300  1.000 36.96330  ? 441 TYR F CZ  1 
ATOM   2901 O OH  . TYR A 1 406 ? 164.76100 354.27200 34.20300  1.000 35.77936  ? 441 TYR F OH  1 
ATOM   2902 N N   . VAL A 1 407 ? 163.96600 359.79000 33.22800  1.000 33.56142  ? 442 VAL F N   1 
ATOM   2903 C CA  . VAL A 1 407 ? 162.54700 359.56100 33.45100  1.000 37.71251  ? 442 VAL F CA  1 
ATOM   2904 C C   . VAL A 1 407 ? 162.29700 358.09200 33.12100  1.000 39.66224  ? 442 VAL F C   1 
ATOM   2905 O O   . VAL A 1 407 ? 162.86800 357.56700 32.16000  1.000 37.23951  ? 442 VAL F O   1 
ATOM   2906 C CB  . VAL A 1 407 ? 161.62800 360.50000 32.63000  1.000 32.60628  ? 442 VAL F CB  1 
ATOM   2907 C CG1 . VAL A 1 407 ? 161.76800 360.23800 31.12400  1.000 32.50787  ? 442 VAL F CG1 1 
ATOM   2908 C CG2 . VAL A 1 407 ? 160.21900 360.33300 33.07400  1.000 40.29697  ? 442 VAL F CG2 1 
ATOM   2909 N N   . SER A 1 408 ? 161.44600 357.42600 33.91400  1.000 38.45049  ? 443 SER F N   1 
ATOM   2910 C CA  . SER A 1 408 ? 161.03800 356.03100 33.72500  1.000 37.95855  ? 443 SER F CA  1 
ATOM   2911 C C   . SER A 1 408 ? 159.96800 355.97200 32.64200  1.000 37.78258  ? 443 SER F C   1 
ATOM   2912 O O   . SER A 1 408 ? 159.40500 356.98900 32.24800  1.000 37.44881  ? 443 SER F O   1 
ATOM   2913 C CB  . SER A 1 408 ? 160.52500 355.34900 35.00000  1.000 43.33383  ? 443 SER F CB  1 
ATOM   2914 O OG  . SER A 1 408 ? 159.34800 355.91500 35.48800  1.000 43.53995  ? 443 SER F OG  1 
ATOM   2915 N N   . ASN A 1 409 ? 159.69700 354.76700 32.13800  1.000 41.68206  ? 444 ASN F N   1 
ATOM   2916 C CA  . ASN A 1 409 ? 158.66300 354.60600 31.12500  1.000 43.59825  ? 444 ASN F CA  1 
ATOM   2917 C C   . ASN A 1 409 ? 157.25200 354.58600 31.71800  1.000 46.28108  ? 444 ASN F C   1 
ATOM   2918 O O   . ASN A 1 409 ? 156.29800 354.37000 30.95600  1.000 46.93849  ? 444 ASN F O   1 
ATOM   2919 C CB  . ASN A 1 409 ? 158.87900 353.33100 30.29400  1.000 40.11331  ? 444 ASN F CB  1 
ATOM   2920 C CG  . ASN A 1 409 ? 158.88400 352.07100 31.13200  1.000 43.53480  ? 444 ASN F CG  1 
ATOM   2921 O OD1 . ASN A 1 409 ? 158.76100 352.10800 32.34700  1.000 43.27815  ? 444 ASN F OD1 1 
ATOM   2922 N ND2 . ASN A 1 409 ? 159.10800 350.95400 30.48200  1.000 43.05991  ? 444 ASN F ND2 1 
ATOM   2923 N N   . LYS A 1 410 ? 157.10300 354.60100 33.04800  1.000 44.92842  ? 445 LYS F N   1 
ATOM   2924 C CA  . LYS A 1 410 ? 155.77600 354.61800 33.68700  1.000 47.58053  ? 445 LYS F CA  1 
ATOM   2925 C C   . LYS A 1 410 ? 155.12000 355.99100 33.58300  1.000 47.92855  ? 445 LYS F C   1 
ATOM   2926 O O   . LYS A 1 410 ? 155.50000 356.94300 34.26700  1.000 50.86286  ? 445 LYS F O   1 
ATOM   2927 C CB  . LYS A 1 410 ? 155.82700 354.11000 35.12400  1.000 51.94897  ? 445 LYS F CB  1 
ATOM   2928 C CG  . LYS A 1 410 ? 156.19000 352.62200 35.16700  1.000 59.98554  ? 445 LYS F CG  1 
ATOM   2929 C CD  . LYS A 1 410 ? 156.14500 352.00900 36.56300  1.000 62.33406  ? 445 LYS F CD  1 
ATOM   2930 C CE  . LYS A 1 410 ? 156.38800 350.49900 36.49500  1.000 61.93999  ? 445 LYS F CE  1 
ATOM   2931 N NZ  . LYS A 1 410 ? 156.54700 350.00900 35.08300  1.000 63.52050  ? 445 LYS F NZ  1 
ATOM   2932 N N   . GLY A 1 411 ? 154.19200 356.11700 32.65800  1.000 48.63072  ? 446 GLY F N   1 
ATOM   2933 C CA  . GLY A 1 411 ? 153.46100 357.34600 32.41700  1.000 48.63405  ? 446 GLY F CA  1 
ATOM   2934 C C   . GLY A 1 411 ? 154.05400 358.20200 31.32000  1.000 50.36710  ? 446 GLY F C   1 
ATOM   2935 O O   . GLY A 1 411 ? 153.43100 359.18700 30.90900  1.000 51.17554  ? 446 GLY F O   1 
ATOM   2936 N N   . VAL A 1 412 ? 155.24300 357.85000 30.84200  1.000 50.02542  ? 447 VAL F N   1 
ATOM   2937 C CA  . VAL A 1 412 ? 155.94200 358.56200 29.78100  1.000 43.89461  ? 447 VAL F CA  1 
ATOM   2938 C C   . VAL A 1 412 ? 155.90400 357.69500 28.53600  1.000 43.09088  ? 447 VAL F C   1 
ATOM   2939 O O   . VAL A 1 412 ? 156.15600 356.48800 28.62000  1.000 47.31650  ? 447 VAL F O   1 
ATOM   2940 C CB  . VAL A 1 412 ? 157.39100 358.90300 30.16500  1.000 37.36619  ? 447 VAL F CB  1 
ATOM   2941 C CG1 . VAL A 1 412 ? 158.09100 359.56500 28.98000  1.000 35.09016  ? 447 VAL F CG1 1 
ATOM   2942 C CG2 . VAL A 1 412 ? 157.38400 359.80000 31.34700  1.000 39.93527  ? 447 VAL F CG2 1 
ATOM   2943 N N   . ASP A 1 413 ? 155.58500 358.29600 27.39900  1.000 43.89017  ? 448 ASP F N   1 
ATOM   2944 C CA  . ASP A 1 413 ? 155.58800 357.63100 26.10300  1.000 42.32811  ? 448 ASP F CA  1 
ATOM   2945 C C   . ASP A 1 413 ? 156.75300 358.13200 25.26100  1.000 43.71732  ? 448 ASP F C   1 
ATOM   2946 O O   . ASP A 1 413 ? 157.45200 357.33800 24.60900  1.000 42.08561  ? 448 ASP F O   1 
ATOM   2947 C CB  . ASP A 1 413 ? 154.28600 357.86200 25.29900  1.000 46.66190  ? 448 ASP F CB  1 
ATOM   2948 C CG  . ASP A 1 413 ? 153.05700 357.24800 25.95300  1.000 57.08633  ? 448 ASP F CG  1 
ATOM   2949 O OD1 . ASP A 1 413 ? 153.17200 356.19800 26.63900  1.000 62.34203  ? 448 ASP F OD1 1 
ATOM   2950 O OD2 . ASP A 1 413 ? 151.96100 357.82300 25.75900  1.000 61.66430  ? 448 ASP F OD2 1 
ATOM   2951 N N   . THR A 1 414 ? 156.95800 359.45100 25.23300  1.000 36.92496  ? 449 THR F N   1 
ATOM   2952 C CA  . THR A 1 414 ? 158.00500 360.03800 24.41400  1.000 36.76222  ? 449 THR F CA  1 
ATOM   2953 C C   . THR A 1 414 ? 158.85500 361.03800 25.20300  1.000 38.27547  ? 449 THR F C   1 
ATOM   2954 O O   . THR A 1 414 ? 158.45200 361.60400 26.22600  1.000 35.64011  ? 449 THR F O   1 
ATOM   2955 C CB  . THR A 1 414 ? 157.44200 360.76000 23.19500  1.000 39.17627  ? 449 THR F CB  1 
ATOM   2956 O OG1 . THR A 1 414 ? 156.59300 361.80100 23.64900  1.000 41.19506  ? 449 THR F OG1 1 
ATOM   2957 C CG2 . THR A 1 414 ? 156.60200 359.79200 22.33500  1.000 40.88480  ? 449 THR F CG2 1 
ATOM   2958 N N   . VAL A 1 415 ? 160.03200 361.28200 24.64900  1.000 36.28089  ? 450 VAL F N   1 
ATOM   2959 C CA  . VAL A 1 415 ? 160.99300 362.24400 25.14300  1.000 32.84630  ? 450 VAL F CA  1 
ATOM   2960 C C   . VAL A 1 415 ? 161.42600 363.07800 23.95000  1.000 34.87819  ? 450 VAL F C   1 
ATOM   2961 O O   . VAL A 1 415 ? 161.62400 362.52300 22.87100  1.000 33.61939  ? 450 VAL F O   1 
ATOM   2962 C CB  . VAL A 1 415 ? 162.18600 361.52100 25.80200  1.000 37.32017  ? 450 VAL F CB  1 
ATOM   2963 C CG1 . VAL A 1 415 ? 163.33000 362.44500 25.99900  1.000 34.73912  ? 450 VAL F CG1 1 
ATOM   2964 C CG2 . VAL A 1 415 ? 161.75200 360.95400 27.16400  1.000 33.64753  ? 450 VAL F CG2 1 
ATOM   2965 N N   . SER A 1 416 ? 161.33000 364.40700 24.06500  1.000 30.38596  ? 451 SER F N   1 
ATOM   2966 C CA  . SER A 1 416 ? 161.70800 365.32900 22.99100  1.000 31.90927  ? 451 SER F CA  1 
ATOM   2967 C C   . SER A 1 416 ? 162.92200 366.09600 23.44200  1.000 31.35215  ? 451 SER F C   1 
ATOM   2968 O O   . SER A 1 416 ? 162.91200 366.66300 24.53500  1.000 32.10823  ? 451 SER F O   1 
ATOM   2969 C CB  . SER A 1 416 ? 160.60900 366.33000 22.59700  1.000 31.94140  ? 451 SER F CB  1 
ATOM   2970 O OG  . SER A 1 416 ? 159.51800 365.65000 22.02600  1.000 48.41286  ? 451 SER F OG  1 
ATOM   2971 N N   . VAL A 1 417 ? 163.95200 366.12900 22.59900  1.000 32.13174  ? 452 VAL F N   1 
ATOM   2972 C CA  . VAL A 1 417 ? 165.15900 366.88900 22.85900  1.000 28.11865  ? 452 VAL F CA  1 
ATOM   2973 C C   . VAL A 1 417 ? 165.47200 367.76900 21.64200  1.000 31.37102  ? 452 VAL F C   1 
ATOM   2974 O O   . VAL A 1 417 ? 165.75900 367.25200 20.54800  1.000 34.39136  ? 452 VAL F O   1 
ATOM   2975 C CB  . VAL A 1 417 ? 166.32500 365.95200 23.17500  1.000 35.42949  ? 452 VAL F CB  1 
ATOM   2976 C CG1 . VAL A 1 417 ? 167.58500 366.74300 23.25500  1.000 32.95932  ? 452 VAL F CG1 1 
ATOM   2977 C CG2 . VAL A 1 417 ? 166.03000 365.15200 24.48000  1.000 28.73127  ? 452 VAL F CG2 1 
ATOM   2978 N N   . GLY A 1 418 ? 165.29300 369.07200 21.77800  1.000 29.92915  ? 453 GLY F N   1 
ATOM   2979 C CA  . GLY A 1 418 ? 165.49700 369.91200 20.59400  1.000 28.84622  ? 453 GLY F CA  1 
ATOM   2980 C C   . GLY A 1 418 ? 164.44100 369.56300 19.55800  1.000 34.20782  ? 453 GLY F C   1 
ATOM   2981 O O   . GLY A 1 418 ? 163.27200 369.36600 19.90600  1.000 32.15561  ? 453 GLY F O   1 
ATOM   2982 N N   . ASN A 1 419 ? 164.86400 369.29200 18.31500  1.000 29.04270  ? 454 ASN F N   1 
ATOM   2983 C CA  . ASN A 1 419 ? 163.94200 368.90500 17.25200  1.000 33.74747  ? 454 ASN F CA  1 
ATOM   2984 C C   . ASN A 1 419 ? 163.78800 367.40600 17.06900  1.000 38.71034  ? 454 ASN F C   1 
ATOM   2985 O O   . ASN A 1 419 ? 163.18100 366.97900 16.06800  1.000 42.05672  ? 454 ASN F O   1 
ATOM   2986 C CB  . ASN A 1 419 ? 164.43400 369.48000 15.91000  1.000 36.45195  ? 454 ASN F CB  1 
ATOM   2987 C CG  . ASN A 1 419 ? 164.48500 370.98600 15.89600  1.000 34.84435  ? 454 ASN F CG  1 
ATOM   2988 O OD1 . ASN A 1 419 ? 163.71700 371.62400 16.60100  1.000 40.02679  ? 454 ASN F OD1 1 
ATOM   2989 N ND2 . ASN A 1 419 ? 165.43700 371.56200 15.15300  1.000 29.62878  ? 454 ASN F ND2 1 
ATOM   2990 N N   . THR A 1 420 ? 164.21500 366.60400 18.03600  1.000 32.80412  ? 455 THR F N   1 
ATOM   2991 C CA  . THR A 1 420 ? 164.14400 365.15500 17.92300  1.000 37.49878  ? 455 THR F CA  1 
ATOM   2992 C C   . THR A 1 420 ? 163.19200 364.51100 18.92400  1.000 35.78816  ? 455 THR F C   1 
ATOM   2993 O O   . THR A 1 420 ? 163.29000 364.75600 20.13000  1.000 39.81205  ? 455 THR F O   1 
ATOM   2994 C CB  . THR A 1 420 ? 165.52900 364.51900 18.06800  1.000 37.59035  ? 455 THR F CB  1 
ATOM   2995 O OG1 . THR A 1 420 ? 166.40200 365.06100 17.06500  1.000 40.61719  ? 455 THR F OG1 1 
ATOM   2996 C CG2 . THR A 1 420 ? 165.40500 363.04600 17.85700  1.000 35.63718  ? 455 THR F CG2 1 
ATOM   2997 N N   . LEU A 1 421 ? 162.38300 363.57400 18.45300  1.000 35.40059  ? 456 LEU F N   1 
ATOM   2998 C CA  . LEU A 1 421 ? 161.45500 362.87100 19.31700  1.000 35.33255  ? 456 LEU F CA  1 
ATOM   2999 C C   . LEU A 1 421 ? 161.86900 361.40500 19.38300  1.000 36.39419  ? 456 LEU F C   1 
ATOM   3000 O O   . LEU A 1 421 ? 162.13900 360.78200 18.35600  1.000 44.41554  ? 456 LEU F O   1 
ATOM   3001 C CB  . LEU A 1 421 ? 160.02900 362.99500 18.78900  1.000 38.59469  ? 456 LEU F CB  1 
ATOM   3002 C CG  . LEU A 1 421 ? 159.02800 362.31100 19.72200  1.000 43.43190  ? 456 LEU F CG  1 
ATOM   3003 C CD1 . LEU A 1 421 ? 157.79400 363.10600 19.93700  1.000 43.00601  ? 456 LEU F CD1 1 
ATOM   3004 C CD2 . LEU A 1 421 ? 158.65000 361.01200 19.05000  1.000 49.67753  ? 456 LEU F CD2 1 
ATOM   3005 N N   . TYR A 1 422 ? 162.12500 360.93800 20.60200  1.000 35.40675  ? 457 TYR F N   1 
ATOM   3006 C CA  . TYR A 1 422 ? 162.46600 359.56300 20.92300  1.000 39.52908  ? 457 TYR F CA  1 
ATOM   3007 C C   . TYR A 1 422 ? 161.27100 358.87000 21.55900  1.000 41.07880  ? 457 TYR F C   1 
ATOM   3008 O O   . TYR A 1 422 ? 160.59500 359.46700 22.40700  1.000 39.51849  ? 457 TYR F O   1 
ATOM   3009 C CB  . TYR A 1 422 ? 163.64100 359.50100 21.90000  1.000 37.82092  ? 457 TYR F CB  1 
ATOM   3010 C CG  . TYR A 1 422 ? 164.85800 360.30000 21.48500  1.000 39.81789  ? 457 TYR F CG  1 
ATOM   3011 C CD1 . TYR A 1 422 ? 164.96400 361.63300 21.83500  1.000 37.16211  ? 457 TYR F CD1 1 
ATOM   3012 C CD2 . TYR A 1 422 ? 165.85700 359.75300 20.68700  1.000 43.31365  ? 457 TYR F CD2 1 
ATOM   3013 C CE1 . TYR A 1 422 ? 166.06600 362.38800 21.48000  1.000 39.11418  ? 457 TYR F CE1 1 
ATOM   3014 C CE2 . TYR A 1 422 ? 166.96600 360.50800 20.30100  1.000 44.62318  ? 457 TYR F CE2 1 
ATOM   3015 C CZ  . TYR A 1 422 ? 167.06100 361.83100 20.70500  1.000 48.14806  ? 457 TYR F CZ  1 
ATOM   3016 O OH  . TYR A 1 422 ? 168.15000 362.61600 20.36800  1.000 54.99706  ? 457 TYR F OH  1 
ATOM   3017 N N   . TYR A 1 423 ? 161.08900 357.58000 21.27300  1.000 38.46925  ? 458 TYR F N   1 
ATOM   3018 C CA  . TYR A 1 423 ? 160.07400 356.79500 21.97400  1.000 39.97605  ? 458 TYR F CA  1 
ATOM   3019 C C   . TYR A 1 423 ? 160.70900 355.92000 23.05200  1.000 37.20286  ? 458 TYR F C   1 
ATOM   3020 O O   . TYR A 1 423 ? 161.70800 355.25300 22.81200  1.000 38.21161  ? 458 TYR F O   1 
ATOM   3021 C CB  . TYR A 1 423 ? 159.26100 355.92700 21.00800  1.000 40.54859  ? 458 TYR F CB  1 
ATOM   3022 C CG  . TYR A 1 423 ? 158.61500 356.69200 19.88200  1.000 41.41983  ? 458 TYR F CG  1 
ATOM   3023 C CD1 . TYR A 1 423 ? 159.36400 357.11200 18.78700  1.000 45.11668  ? 458 TYR F CD1 1 
ATOM   3024 C CD2 . TYR A 1 423 ? 157.25500 357.00600 19.90700  1.000 47.22006  ? 458 TYR F CD2 1 
ATOM   3025 C CE1 . TYR A 1 423 ? 158.78000 357.82300 17.74000  1.000 47.72308  ? 458 TYR F CE1 1 
ATOM   3026 C CE2 . TYR A 1 423 ? 156.65600 357.71700 18.84800  1.000 42.93725  ? 458 TYR F CE2 1 
ATOM   3027 C CZ  . TYR A 1 423 ? 157.43400 358.12600 17.78400  1.000 46.85872  ? 458 TYR F CZ  1 
ATOM   3028 O OH  . TYR A 1 423 ? 156.88100 358.83500 16.73600  1.000 58.17258  ? 458 TYR F OH  1 
ATOM   3029 N N   . VAL A 1 424 ? 160.12900 355.96500 24.24700  1.000 35.32538  ? 459 VAL F N   1 
ATOM   3030 C CA  . VAL A 1 424 ? 160.48600 355.12600 25.38700  1.000 36.75596  ? 459 VAL F CA  1 
ATOM   3031 C C   . VAL A 1 424 ? 160.01500 353.68800 25.20000  1.000 42.07567  ? 459 VAL F C   1 
ATOM   3032 O O   . VAL A 1 424 ? 159.04700 353.43100 24.47100  1.000 36.97091  ? 459 VAL F O   1 
ATOM   3033 C CB  . VAL A 1 424 ? 159.95400 355.72300 26.69900  1.000 44.32432  ? 459 VAL F CB  1 
ATOM   3034 C CG1 . VAL A 1 424 ? 160.39600 354.89300 27.83400  1.000 46.16185  ? 459 VAL F CG1 1 
ATOM   3035 C CG2 . VAL A 1 424 ? 160.62700 357.06400 26.92000  1.000 39.41754  ? 459 VAL F CG2 1 
ATOM   3036 N N   . ASN A 1 425 ? 160.86500 352.74300 25.59000  1.000 40.07592  ? 460 ASN F N   1 
ATOM   3037 C CA  . ASN A 1 425 ? 160.49100 351.33200 25.52000  1.000 42.89623  ? 460 ASN F CA  1 
ATOM   3038 C C   . ASN A 1 425 ? 159.38500 351.06000 26.53700  1.000 41.50796  ? 460 ASN F C   1 
ATOM   3039 O O   . ASN A 1 425 ? 159.52600 351.40600 27.71300  1.000 45.52978  ? 460 ASN F O   1 
ATOM   3040 C CB  . ASN A 1 425 ? 161.71800 350.48300 25.87600  1.000 40.61969  ? 460 ASN F CB  1 
ATOM   3041 C CG  . ASN A 1 425 ? 161.48700 348.97100 25.76800  1.000 49.66611  ? 460 ASN F CG  1 
ATOM   3042 O OD1 . ASN A 1 425 ? 160.46300 348.41900 26.18400  1.000 49.21899  ? 460 ASN F OD1 1 
ATOM   3043 N ND2 . ASN A 1 425 ? 162.47400 348.29500 25.21300  1.000 50.77790  ? 460 ASN F ND2 1 
ATOM   3044 N N   . LYS A 1 426 ? 158.28500 350.44300 26.10200  1.000 46.89179  ? 461 LYS F N   1 
ATOM   3045 C CA  . LYS A 1 426 ? 157.14900 350.18400 26.99100  1.000 49.90578  ? 461 LYS F CA  1 
ATOM   3046 C C   . LYS A 1 426 ? 157.22200 348.81400 27.68100  1.000 52.58923  ? 461 LYS F C   1 
ATOM   3047 O O   . LYS A 1 426 ? 156.19200 348.28300 28.10500  1.000 59.17500  ? 461 LYS F O   1 
ATOM   3048 C CB  . LYS A 1 426 ? 155.82500 350.35600 26.24000  1.000 46.53889  ? 461 LYS F CB  1 
ATOM   3049 C CG  . LYS A 1 426 ? 155.62800 351.70900 25.55000  1.000 46.15539  ? 461 LYS F CG  1 
ATOM   3050 C CD  . LYS A 1 426 ? 155.77600 352.89700 26.54800  1.000 48.03266  ? 461 LYS F CD  1 
ATOM   3051 C CE  . LYS A 1 426 ? 154.66400 352.85600 27.61000  1.000 51.85925  ? 461 LYS F CE  1 
ATOM   3052 N NZ  . LYS A 1 426 ? 154.69200 353.92700 28.68500  1.000 47.71201  ? 461 LYS F NZ  1 
ATOM   3053 N N   . GLN A 1 427 ? 158.42300 348.30000 27.90400  1.000 50.06724  ? 462 GLN F N   1 
ATOM   3054 C CA  . GLN A 1 427 ? 158.64800 347.02600 28.57900  1.000 52.09384  ? 462 GLN F CA  1 
ATOM   3055 C C   . GLN A 1 427 ? 158.37800 347.18100 30.07800  1.000 55.67089  ? 462 GLN F C   1 
ATOM   3056 O O   . GLN A 1 427 ? 158.71300 348.20500 30.67700  1.000 47.13126  ? 462 GLN F O   1 
ATOM   3057 C CB  . GLN A 1 427 ? 160.09300 346.59700 28.31700  1.000 55.09053  ? 462 GLN F CB  1 
ATOM   3058 C CG  . GLN A 1 427 ? 160.57900 345.28800 28.87900  1.000 64.17322  ? 462 GLN F CG  1 
ATOM   3059 C CD  . GLN A 1 427 ? 161.97200 345.00000 28.34100  1.000 67.95678  ? 462 GLN F CD  1 
ATOM   3060 O OE1 . GLN A 1 427 ? 162.75800 345.93400 28.11100  1.000 64.59160  ? 462 GLN F OE1 1 
ATOM   3061 N NE2 . GLN A 1 427 ? 162.25900 343.72100 28.04700  1.000 75.26245  ? 462 GLN F NE2 1 
ATOM   3062 N N   . GLU A 1 428 ? 157.78100 346.16300 30.69300  1.000 54.41159  ? 463 GLU F N   1 
ATOM   3063 C CA  . GLU A 1 428 ? 157.46900 346.21900 32.12100  1.000 52.13073  ? 463 GLU F CA  1 
ATOM   3064 C C   . GLU A 1 428 ? 158.69400 345.96800 32.99700  1.000 46.77609  ? 463 GLU F C   1 
ATOM   3065 O O   . GLU A 1 428 ? 159.55700 345.15600 32.65900  1.000 52.57968  ? 463 GLU F O   1 
ATOM   3066 C CB  . GLU A 1 428 ? 156.39600 345.18700 32.47600  1.000 61.72230  ? 463 GLU F CB  1 
ATOM   3067 C CG  . GLU A 1 428 ? 155.38300 345.69900 33.50200  1.000 73.42544  ? 463 GLU F CG  1 
ATOM   3068 C CD  . GLU A 1 428 ? 154.22600 346.47900 32.87600  1.000 82.92439  ? 463 GLU F CD  1 
ATOM   3069 O OE1 . GLU A 1 428 ? 153.94500 346.27800 31.66500  1.000 80.34124  ? 463 GLU F OE1 1 
ATOM   3070 O OE2 . GLU A 1 428 ? 153.59300 347.28400 33.60800  1.000 86.38135  ? 463 GLU F OE2 1 
ATOM   3071 N N   . GLY A 1 429 ? 158.82300 346.76100 34.05800  1.000 41.46822  ? 464 GLY F N   1 
ATOM   3072 C CA  . GLY A 1 429 ? 159.93800 346.64800 34.97900  1.000 41.52704  ? 464 GLY F CA  1 
ATOM   3073 C C   . GLY A 1 429 ? 159.90800 347.79700 35.96200  1.000 47.65575  ? 464 GLY F C   1 
ATOM   3074 O O   . GLY A 1 429 ? 159.10600 348.71800 35.83500  1.000 55.17560  ? 464 GLY F O   1 
ATOM   3075 N N   . LYS A 1 430 ? 160.83800 347.76800 36.91400  1.000 44.94836  ? 465 LYS F N   1 
ATOM   3076 C CA  . LYS A 1 430 ? 160.92200 348.80600 37.93300  1.000 45.15980  ? 465 LYS F CA  1 
ATOM   3077 C C   . LYS A 1 430 ? 162.20700 349.61600 37.80400  1.000 46.68425  ? 465 LYS F C   1 
ATOM   3078 O O   . LYS A 1 430 ? 163.29300 349.04500 37.68800  1.000 46.12343  ? 465 LYS F O   1 
ATOM   3079 C CB  . LYS A 1 430 ? 160.84100 348.20800 39.32900  1.000 49.58166  ? 465 LYS F CB  1 
ATOM   3080 C CG  . LYS A 1 430 ? 159.50600 347.50200 39.58200  1.000 66.07715  ? 465 LYS F CG  1 
ATOM   3081 C CD  . LYS A 1 430 ? 159.38200 347.00000 41.03700  1.000 74.79609  ? 465 LYS F CD  1 
ATOM   3082 C CE  . LYS A 1 430 ? 158.26600 345.96600 41.16800  1.000 74.48217  ? 465 LYS F CE  1 
ATOM   3083 N NZ  . LYS A 1 430 ? 157.04500 346.37700 40.39300  1.000 76.89731  ? 465 LYS F NZ  1 
ATOM   3084 N N   . SER A 1 431 ? 162.08000 350.93800 37.86400  1.000 40.00527  ? 466 SER F N   1 
ATOM   3085 C CA  . SER A 1 431 ? 163.20000 351.85900 37.81000  1.000 39.44292  ? 466 SER F CA  1 
ATOM   3086 C C   . SER A 1 431 ? 163.44000 352.47200 39.17000  1.000 45.11410  ? 466 SER F C   1 
ATOM   3087 O O   . SER A 1 431 ? 162.50100 352.83800 39.87700  1.000 50.33066  ? 466 SER F O   1 
ATOM   3088 C CB  . SER A 1 431 ? 162.95900 353.02200 36.84000  1.000 39.56449  ? 466 SER F CB  1 
ATOM   3089 O OG  . SER A 1 431 ? 162.76600 352.57300 35.52600  1.000 48.05182  ? 466 SER F OG  1 
ATOM   3090 N N   . LEU A 1 432 ? 164.70700 352.74100 39.44300  1.000 42.26282  ? 467 LEU F N   1 
ATOM   3091 C CA  . LEU A 1 432 ? 165.13600 353.33100 40.69400  1.000 43.93676  ? 467 LEU F CA  1 
ATOM   3092 C C   . LEU A 1 432 ? 166.02700 354.51600 40.37200  1.000 44.36540  ? 467 LEU F C   1 
ATOM   3093 O O   . LEU A 1 432 ? 167.06300 354.36200 39.71000  1.000 42.85648  ? 467 LEU F O   1 
ATOM   3094 C CB  . LEU A 1 432 ? 165.90700 352.32200 41.55400  1.000 45.56809  ? 467 LEU F CB  1 
ATOM   3095 C CG  . LEU A 1 432 ? 166.38800 352.85600 42.91900  1.000 53.74773  ? 467 LEU F CG  1 
ATOM   3096 C CD1 . LEU A 1 432 ? 165.21800 353.36700 43.78700  1.000 50.99477  ? 467 LEU F CD1 1 
ATOM   3097 C CD2 . LEU A 1 432 ? 167.27100 351.86900 43.68800  1.000 53.79376  ? 467 LEU F CD2 1 
ATOM   3098 N N   . TYR A 1 433 ? 165.61700 355.68500 40.83100  1.000 41.56897  ? 468 TYR F N   1 
ATOM   3099 C CA  . TYR A 1 433 ? 166.35300 356.91800 40.63500  1.000 42.36283  ? 468 TYR F CA  1 
ATOM   3100 C C   . TYR A 1 433 ? 167.23900 357.06800 41.85900  1.000 48.19014  ? 468 TYR F C   1 
ATOM   3101 O O   . TYR A 1 433 ? 166.74200 357.32200 42.96200  1.000 48.02078  ? 468 TYR F O   1 
ATOM   3102 C CB  . TYR A 1 433 ? 165.41200 358.11300 40.54400  1.000 37.53197  ? 468 TYR F CB  1 
ATOM   3103 C CG  . TYR A 1 433 ? 166.01900 359.37100 39.94100  1.000 39.28554  ? 468 TYR F CG  1 
ATOM   3104 C CD1 . TYR A 1 433 ? 166.92800 360.13500 40.65800  1.000 39.10691  ? 468 TYR F CD1 1 
ATOM   3105 C CD2 . TYR A 1 433 ? 165.55600 359.88000 38.73600  1.000 35.46254  ? 468 TYR F CD2 1 
ATOM   3106 C CE1 . TYR A 1 433 ? 167.44800 361.31700 40.14100  1.000 39.75642  ? 468 TYR F CE1 1 
ATOM   3107 C CE2 . TYR A 1 433 ? 166.05700 361.06100 38.21700  1.000 36.38492  ? 468 TYR F CE2 1 
ATOM   3108 C CZ  . TYR A 1 433 ? 167.00300 361.77200 38.91500  1.000 36.71694  ? 468 TYR F CZ  1 
ATOM   3109 O OH  . TYR A 1 433 ? 167.49800 362.95300 38.37400  1.000 36.45961  ? 468 TYR F OH  1 
ATOM   3110 N N   . VAL A 1 434 ? 168.54300 356.87900 41.68500  1.000 43.07619  ? 469 VAL F N   1 
ATOM   3111 C CA  . VAL A 1 434 ? 169.49100 356.98700 42.78100  1.000 39.89265  ? 469 VAL F CA  1 
ATOM   3112 C C   . VAL A 1 434 ? 170.00800 358.42500 42.79200  1.000 48.30181  ? 469 VAL F C   1 
ATOM   3113 O O   . VAL A 1 434 ? 170.86200 358.79800 41.97800  1.000 44.98281  ? 469 VAL F O   1 
ATOM   3114 C CB  . VAL A 1 434 ? 170.62100 355.97500 42.63300  1.000 41.40221  ? 469 VAL F CB  1 
ATOM   3115 C CG1 . VAL A 1 434 ? 171.58800 356.11800 43.79000  1.000 40.63947  ? 469 VAL F CG1 1 
ATOM   3116 C CG2 . VAL A 1 434 ? 170.04600 354.54900 42.49000  1.000 37.07127  ? 469 VAL F CG2 1 
ATOM   3117 N N   . LYS A 1 435 ? 169.45900 359.25200 43.67900  1.000 43.23122  ? 470 LYS F N   1 
ATOM   3118 C CA  . LYS A 1 435 ? 169.86500 360.64800 43.73600  1.000 44.75021  ? 470 LYS F CA  1 
ATOM   3119 C C   . LYS A 1 435 ? 171.29300 360.77000 44.24100  1.000 45.70792  ? 470 LYS F C   1 
ATOM   3120 O O   . LYS A 1 435 ? 171.79000 359.92100 44.97700  1.000 48.19881  ? 470 LYS F O   1 
ATOM   3121 C CB  . LYS A 1 435 ? 168.90000 361.46900 44.59600  1.000 48.60750  ? 470 LYS F CB  1 
ATOM   3122 C CG  . LYS A 1 435 ? 167.43600 361.28600 44.15000  1.000 52.62256  ? 470 LYS F CG  1 
ATOM   3123 C CD  . LYS A 1 435 ? 166.37700 361.82900 45.11100  1.000 64.14685  ? 470 LYS F CD  1 
ATOM   3124 C CE  . LYS A 1 435 ? 165.60500 360.65200 45.78100  1.000 73.90059  ? 470 LYS F CE  1 
ATOM   3125 N NZ  . LYS A 1 435 ? 165.22500 360.85600 47.21900  1.000 75.93139  ? 470 LYS F NZ  1 
ATOM   3126 N N   . GLY A 1 436 ? 171.98200 361.80800 43.77300  1.000 40.13929  ? 471 GLY F N   1 
ATOM   3127 C CA  . GLY A 1 436 ? 173.36100 362.00200 44.18400  1.000 41.54127  ? 471 GLY F CA  1 
ATOM   3128 C C   . GLY A 1 436 ? 173.92000 363.22100 43.49300  1.000 43.76927  ? 471 GLY F C   1 
ATOM   3129 O O   . GLY A 1 436 ? 173.44600 363.60400 42.41900  1.000 43.64675  ? 471 GLY F O   1 
ATOM   3130 N N   . GLU A 1 437 ? 174.90600 363.84800 44.10400  1.000 42.77164  ? 472 GLU F N   1 
ATOM   3131 C CA  . GLU A 1 437 ? 175.50200 365.05000 43.52800  1.000 47.72370  ? 472 GLU F CA  1 
ATOM   3132 C C   . GLU A 1 437 ? 176.25800 364.74700 42.23600  1.000 42.36997  ? 472 GLU F C   1 
ATOM   3133 O O   . GLU A 1 437 ? 177.10000 363.83600 42.21700  1.000 40.85490  ? 472 GLU F O   1 
ATOM   3134 C CB  . GLU A 1 437 ? 176.39800 365.73600 44.55400  1.000 46.56751  ? 472 GLU F CB  1 
ATOM   3135 C CG  . GLU A 1 437 ? 177.10500 366.93000 43.95700  1.000 48.91668  ? 472 GLU F CG  1 
ATOM   3136 C CD  . GLU A 1 437 ? 176.27000 368.17600 44.00500  1.000 59.88593  ? 472 GLU F CD  1 
ATOM   3137 O OE1 . GLU A 1 437 ? 175.43200 368.30000 44.93200  1.000 70.09514  ? 472 GLU F OE1 1 
ATOM   3138 O OE2 . GLU A 1 437 ? 176.42500 369.01500 43.07700  1.000 61.07394  ? 472 GLU F OE2 1 
ATOM   3139 N N   . PRO A 1 438 ? 176.01600 365.48600 41.14700  1.000 43.79093  ? 473 PRO F N   1 
ATOM   3140 C CA  . PRO A 1 438 ? 176.80100 365.21400 39.93100  1.000 38.09948  ? 473 PRO F CA  1 
ATOM   3141 C C   . PRO A 1 438 ? 178.27900 365.41200 40.23300  1.000 42.80923  ? 473 PRO F C   1 
ATOM   3142 O O   . PRO A 1 438 ? 178.71400 366.46600 40.71100  1.000 42.47624  ? 473 PRO F O   1 
ATOM   3143 C CB  . PRO A 1 438 ? 176.26200 366.23600 38.92200  1.000 40.55877  ? 473 PRO F CB  1 
ATOM   3144 C CG  . PRO A 1 438 ? 174.82500 366.57800 39.45500  1.000 42.44130  ? 473 PRO F CG  1 
ATOM   3145 C CD  . PRO A 1 438 ? 174.97000 366.51500 40.95000  1.000 44.21523  ? 473 PRO F CD  1 
ATOM   3146 N N   . ILE A 1 439 ? 179.05900 364.37000 39.95300  1.000 38.82633  ? 474 ILE F N   1 
ATOM   3147 C CA  . ILE A 1 439 ? 180.46500 364.42700 40.34100  1.000 40.82549  ? 474 ILE F CA  1 
ATOM   3148 C C   . ILE A 1 439 ? 181.25100 365.46900 39.57900  1.000 39.54032  ? 474 ILE F C   1 
ATOM   3149 O O   . ILE A 1 439 ? 182.30400 365.89400 40.06600  1.000 39.99139  ? 474 ILE F O   1 
ATOM   3150 C CB  . ILE A 1 439 ? 181.18900 363.08000 40.18000  1.000 37.43089  ? 474 ILE F CB  1 
ATOM   3151 C CG1 . ILE A 1 439 ? 181.31800 362.76100 38.69300  1.000 38.82112  ? 474 ILE F CG1 1 
ATOM   3152 C CG2 . ILE A 1 439 ? 180.47000 361.98300 41.00000  1.000 32.79214  ? 474 ILE F CG2 1 
ATOM   3153 C CD1 . ILE A 1 439 ? 182.08100 361.51100 38.37900  1.000 37.43458  ? 474 ILE F CD1 1 
ATOM   3154 N N   . ILE A 1 440 ? 180.70800 365.99100 38.47000  1.000 39.58690  ? 475 ILE F N   1 
ATOM   3155 C CA  . ILE A 1 440 ? 181.41900 367.01900 37.71700  1.000 33.52957  ? 475 ILE F CA  1 
ATOM   3156 C C   . ILE A 1 440 ? 181.50500 368.28700 38.54700  1.000 39.11505  ? 475 ILE F C   1 
ATOM   3157 O O   . ILE A 1 440 ? 182.40300 369.10700 38.32900  1.000 38.27305  ? 475 ILE F O   1 
ATOM   3158 C CB  . ILE A 1 440 ? 180.74000 367.28200 36.34900  1.000 36.34926  ? 475 ILE F CB  1 
ATOM   3159 C CG1 . ILE A 1 440 ? 181.64500 368.09900 35.41400  1.000 38.19161  ? 475 ILE F CG1 1 
ATOM   3160 C CG2 . ILE A 1 440 ? 179.38400 368.01200 36.50600  1.000 34.92469  ? 475 ILE F CG2 1 
ATOM   3161 C CD1 . ILE A 1 440 ? 182.94000 367.41800 35.06800  1.000 38.42210  ? 475 ILE F CD1 1 
ATOM   3162 N N   . ASN A 1 441 ? 180.61900 368.44600 39.53400  1.000 39.30821  ? 476 ASN F N   1 
ATOM   3163 C CA  . ASN A 1 441 ? 180.67000 369.61600 40.40500  1.000 48.00916  ? 476 ASN F CA  1 
ATOM   3164 C C   . ASN A 1 441 ? 181.79900 369.55000 41.43600  1.000 44.94485  ? 476 ASN F C   1 
ATOM   3165 O O   . ASN A 1 441 ? 181.97100 370.50600 42.18500  1.000 48.46090  ? 476 ASN F O   1 
ATOM   3166 C CB  . ASN A 1 441 ? 179.35100 369.83400 41.14500  1.000 43.03335  ? 476 ASN F CB  1 
ATOM   3167 C CG  . ASN A 1 441 ? 178.18800 370.08400 40.21800  1.000 44.94802  ? 476 ASN F CG  1 
ATOM   3168 O OD1 . ASN A 1 441 ? 178.35200 370.56400 39.08600  1.000 51.48429  ? 476 ASN F OD1 1 
ATOM   3169 N ND2 . ASN A 1 441 ? 176.98800 369.80300 40.71000  1.000 48.40375  ? 476 ASN F ND2 1 
ATOM   3170 N N   . PHE A 1 442 ? 182.47500 368.42000 41.60300  1.000 45.40249  ? 477 PHE F N   1 
ATOM   3171 C CA  . PHE A 1 442 ? 183.58500 368.32900 42.56200  1.000 46.63759  ? 477 PHE F CA  1 
ATOM   3172 C C   . PHE A 1 442 ? 184.92600 368.79800 42.00600  1.000 46.11968  ? 477 PHE F C   1 
ATOM   3173 O O   . PHE A 1 442 ? 185.93000 368.74800 42.71600  1.000 51.76457  ? 477 PHE F O   1 
ATOM   3174 C CB  . PHE A 1 442 ? 183.75100 366.87900 43.01100  1.000 45.85030  ? 477 PHE F CB  1 
ATOM   3175 C CG  . PHE A 1 442 ? 182.53700 366.30900 43.68200  1.000 48.64410  ? 477 PHE F CG  1 
ATOM   3176 C CD1 . PHE A 1 442 ? 181.70400 367.11500 44.43700  1.000 51.93349  ? 477 PHE F CD1 1 
ATOM   3177 C CD2 . PHE A 1 442 ? 182.19300 364.97800 43.50200  1.000 49.89258  ? 477 PHE F CD2 1 
ATOM   3178 C CE1 . PHE A 1 442 ? 180.58200 366.58200 45.06700  1.000 51.82207  ? 477 PHE F CE1 1 
ATOM   3179 C CE2 . PHE A 1 442 ? 181.06200 364.43900 44.10500  1.000 50.47134  ? 477 PHE F CE2 1 
ATOM   3180 C CZ  . PHE A 1 442 ? 180.25100 365.24700 44.88700  1.000 53.02935  ? 477 PHE F CZ  1 
ATOM   3181 N N   . TYR A 1 443 ? 184.96200 369.31600 40.79500  1.000 45.50054  ? 478 TYR F N   1 
ATOM   3182 C CA  . TYR A 1 443 ? 186.20100 369.62400 40.10900  1.000 43.67959  ? 478 TYR F CA  1 
ATOM   3183 C C   . TYR A 1 443 ? 186.33700 371.11900 39.92100  1.000 49.48891  ? 478 TYR F C   1 
ATOM   3184 O O   . TYR A 1 443 ? 185.36300 371.78600 39.54500  1.000 48.32637  ? 478 TYR F O   1 
ATOM   3185 C CB  . TYR A 1 443 ? 186.19800 368.96300 38.73100  1.000 43.85313  ? 478 TYR F CB  1 
ATOM   3186 C CG  . TYR A 1 443 ? 186.36600 367.47700 38.79600  1.000 41.79620  ? 478 TYR F CG  1 
ATOM   3187 C CD1 . TYR A 1 443 ? 187.60800 366.89100 38.98000  1.000 42.09659  ? 478 TYR F CD1 1 
ATOM   3188 C CD2 . TYR A 1 443 ? 185.25300 366.66200 38.71800  1.000 38.36094  ? 478 TYR F CD2 1 
ATOM   3189 C CE1 . TYR A 1 443 ? 187.73600 365.53000 39.04200  1.000 40.44750  ? 478 TYR F CE1 1 
ATOM   3190 C CE2 . TYR A 1 443 ? 185.36100 365.31000 38.78500  1.000 39.13156  ? 478 TYR F CE2 1 
ATOM   3191 C CZ  . TYR A 1 443 ? 186.60600 364.74500 38.94200  1.000 43.12216  ? 478 TYR F CZ  1 
ATOM   3192 O OH  . TYR A 1 443 ? 186.69700 363.38200 39.00000  1.000 43.99432  ? 478 TYR F OH  1 
ATOM   3193 N N   . ASP A 1 444 ? 187.51000 371.65100 40.23900  1.000 46.96731  ? 479 ASP F N   1 
ATOM   3194 C CA  . ASP A 1 444 ? 187.74700 373.05300 39.96600  1.000 50.58364  ? 479 ASP F CA  1 
ATOM   3195 C C   . ASP A 1 444 ? 187.93600 373.17000 38.45500  1.000 49.51275  ? 479 ASP F C   1 
ATOM   3196 O O   . ASP A 1 444 ? 188.85400 372.54600 37.90900  1.000 46.52968  ? 479 ASP F O   1 
ATOM   3197 C CB  . ASP A 1 444 ? 189.01500 373.50000 40.70200  1.000 57.39459  ? 479 ASP F CB  1 
ATOM   3198 C CG  . ASP A 1 444 ? 189.37700 374.95800 40.45900  1.000 57.46564  ? 479 ASP F CG  1 
ATOM   3199 O OD1 . ASP A 1 444 ? 189.43700 375.41600 39.29700  1.000 57.88705  ? 479 ASP F OD1 1 
ATOM   3200 O OD2 . ASP A 1 444 ? 189.68200 375.64000 41.46100  1.000 72.28710  ? 479 ASP F OD2 1 
ATOM   3201 N N   . PRO A 1 445 ? 187.17200 374.03300 37.77200  1.000 50.05109  ? 480 PRO F N   1 
ATOM   3202 C CA  . PRO A 1 445 ? 187.26800 374.10700 36.30400  1.000 45.09248  ? 480 PRO F CA  1 
ATOM   3203 C C   . PRO A 1 445 ? 188.63200 374.53400 35.82300  1.000 54.08401  ? 480 PRO F C   1 
ATOM   3204 O O   . PRO A 1 445 ? 189.02500 374.17200 34.70800  1.000 57.71517  ? 480 PRO F O   1 
ATOM   3205 C CB  . PRO A 1 445 ? 186.19600 375.13200 35.93500  1.000 48.65678  ? 480 PRO F CB  1 
ATOM   3206 C CG  . PRO A 1 445 ? 185.18100 375.05400 37.04100  1.000 49.43985  ? 480 PRO F CG  1 
ATOM   3207 C CD  . PRO A 1 445 ? 185.78200 374.26500 38.20300  1.000 49.57694  ? 480 PRO F CD  1 
ATOM   3208 N N   . LEU A 1 446 ? 189.28700 375.43700 36.54800  1.000 57.36524  ? 481 LEU F N   1 
ATOM   3209 C CA  . LEU A 1 446 ? 190.54100 376.00000 36.06400  1.000 57.59623  ? 481 LEU F CA  1 
ATOM   3210 C C   . LEU A 1 446 ? 191.58000 374.91400 35.84900  1.000 56.53771  ? 481 LEU F C   1 
ATOM   3211 O O   . LEU A 1 446 ? 192.40900 375.03300 34.94300  1.000 62.20863  ? 481 LEU F O   1 
ATOM   3212 C CB  . LEU A 1 446 ? 191.03500 377.09000 37.01200  1.000 65.28377  ? 481 LEU F CB  1 
ATOM   3213 C CG  . LEU A 1 446 ? 189.93100 378.14500 37.18100  1.000 59.49543  ? 481 LEU F CG  1 
ATOM   3214 C CD1 . LEU A 1 446 ? 189.99200 378.89600 38.52000  1.000 63.64037  ? 481 LEU F CD1 1 
ATOM   3215 C CD2 . LEU A 1 446 ? 189.96100 379.08900 35.99800  1.000 63.16152  ? 481 LEU F CD2 1 
ATOM   3216 N N   . VAL A 1 447 ? 191.66500 373.92600 36.74200  1.000 56.14857  ? 482 VAL F N   1 
ATOM   3217 C CA  . VAL A 1 447 ? 192.70600 372.91400 36.56400  1.000 55.88100  ? 482 VAL F CA  1 
ATOM   3218 C C   . VAL A 1 447 ? 192.16000 371.58300 35.99800  1.000 53.30671  ? 482 VAL F C   1 
ATOM   3219 O O   . VAL A 1 447 ? 192.86400 370.56300 36.06000  1.000 49.93759  ? 482 VAL F O   1 
ATOM   3220 C CB  . VAL A 1 447 ? 193.50600 372.69300 37.86100  1.000 59.47881  ? 482 VAL F CB  1 
ATOM   3221 C CG1 . VAL A 1 447 ? 194.29900 373.95400 38.18400  1.000 69.93245  ? 482 VAL F CG1 1 
ATOM   3222 C CG2 . VAL A 1 447 ? 192.58100 372.28600 39.03000  1.000 54.90364  ? 482 VAL F CG2 1 
ATOM   3223 N N   . PHE A 1 448 ? 190.89800 371.54500 35.53100  1.000 51.96898  ? 483 PHE F N   1 
ATOM   3224 C CA  . PHE A 1 448 ? 190.31300 370.29200 35.02500  1.000 44.71300  ? 483 PHE F CA  1 
ATOM   3225 C C   . PHE A 1 448 ? 191.01900 369.92900 33.71000  1.000 43.96074  ? 483 PHE F C   1 
ATOM   3226 O O   . PHE A 1 448 ? 191.07500 370.77500 32.81100  1.000 41.62942  ? 483 PHE F O   1 
ATOM   3227 C CB  . PHE A 1 448 ? 188.81300 370.50300 34.77600  1.000 40.14277  ? 483 PHE F CB  1 
ATOM   3228 C CG  . PHE A 1 448 ? 188.02100 369.23100 34.54100  1.000 36.96980  ? 483 PHE F CG  1 
ATOM   3229 C CD1 . PHE A 1 448 ? 187.95000 368.26800 35.52300  1.000 33.47339  ? 483 PHE F CD1 1 
ATOM   3230 C CD2 . PHE A 1 448 ? 187.38100 368.99300 33.32100  1.000 37.60721  ? 483 PHE F CD2 1 
ATOM   3231 C CE1 . PHE A 1 448 ? 187.23300 367.12100 35.35100  1.000 36.53417  ? 483 PHE F CE1 1 
ATOM   3232 C CE2 . PHE A 1 448 ? 186.66600 367.79900 33.10100  1.000 36.53523  ? 483 PHE F CE2 1 
ATOM   3233 C CZ  . PHE A 1 448 ? 186.58900 366.85700 34.13500  1.000 36.97738  ? 483 PHE F CZ  1 
ATOM   3234 N N   . PRO A 1 449 ? 191.37400 368.62100 33.46100  1.000 39.72362  ? 484 PRO F N   1 
ATOM   3235 C CA  . PRO A 1 449 ? 191.86400 368.23600 32.10800  1.000 47.17166  ? 484 PRO F CA  1 
ATOM   3236 C C   . PRO A 1 449 ? 190.68100 368.03600 31.17800  1.000 38.81559  ? 484 PRO F C   1 
ATOM   3237 O O   . PRO A 1 449 ? 190.15400 366.91900 31.17600  1.000 40.51886  ? 484 PRO F O   1 
ATOM   3238 C CB  . PRO A 1 449 ? 192.57000 366.89200 32.35000  1.000 41.17654  ? 484 PRO F CB  1 
ATOM   3239 C CG  . PRO A 1 449 ? 192.62400 366.72300 33.79300  1.000 44.75407  ? 484 PRO F CG  1 
ATOM   3240 C CD  . PRO A 1 449 ? 191.48800 367.50100 34.39300  1.000 41.58102  ? 484 PRO F CD  1 
ATOM   3241 N N   . SER A 1 450 ? 190.37700 368.97100 30.26700  1.000 38.60096  ? 485 SER F N   1 
ATOM   3242 C CA  . SER A 1 450 ? 189.12200 368.91600 29.50900  1.000 37.35345  ? 485 SER F CA  1 
ATOM   3243 C C   . SER A 1 450 ? 189.11800 368.29200 28.12100  1.000 47.16332  ? 485 SER F C   1 
ATOM   3244 O O   . SER A 1 450 ? 188.13500 368.47500 27.39200  1.000 54.76510  ? 485 SER F O   1 
ATOM   3245 C CB  . SER A 1 450 ? 188.59700 370.34100 29.32200  1.000 42.48639  ? 485 SER F CB  1 
ATOM   3246 O OG  . SER A 1 450 ? 188.00100 370.80600 30.51300  1.000 57.05764  ? 485 SER F OG  1 
ATOM   3247 N N   . ASP A 1 451 ? 190.12400 367.57900 27.70900  1.000 36.92159  ? 486 ASP F N   1 
ATOM   3248 C CA  . ASP A 1 451 ? 190.05100 367.01600 26.35200  1.000 42.22319  ? 486 ASP F CA  1 
ATOM   3249 C C   . ASP A 1 451 ? 190.59300 365.60500 26.40200  1.000 39.51992  ? 486 ASP F C   1 
ATOM   3250 O O   . ASP A 1 451 ? 191.29900 365.16600 25.49700  1.000 37.75223  ? 486 ASP F O   1 
ATOM   3251 C CB  . ASP A 1 451 ? 190.74500 367.86900 25.28300  1.000 42.48916  ? 486 ASP F CB  1 
ATOM   3252 C CG  . ASP A 1 451 ? 190.23800 367.55300 23.82300  1.000 45.19933  ? 486 ASP F CG  1 
ATOM   3253 O OD1 . ASP A 1 451 ? 189.25900 366.80300 23.64100  1.000 38.72853  ? 486 ASP F OD1 1 
ATOM   3254 O OD2 . ASP A 1 451 ? 190.83600 368.06200 22.83700  1.000 46.72740  ? 486 ASP F OD2 1 
ATOM   3255 N N   . GLU A 1 452 ? 190.26700 364.87300 27.45600  1.000 42.04598  ? 487 GLU F N   1 
ATOM   3256 C CA  . GLU A 1 452 ? 190.81700 363.51100 27.64700  1.000 34.83166  ? 487 GLU F CA  1 
ATOM   3257 C C   . GLU A 1 452 ? 189.91300 362.51300 26.92700  1.000 40.74434  ? 487 GLU F C   1 
ATOM   3258 O O   . GLU A 1 452 ? 188.71800 362.51100 27.19000  1.000 41.21284  ? 487 GLU F O   1 
ATOM   3259 C CB  . GLU A 1 452 ? 190.97700 363.20600 29.13400  1.000 39.06097  ? 487 GLU F CB  1 
ATOM   3260 C CG  . GLU A 1 452 ? 191.90000 364.16200 29.85500  1.000 43.64035  ? 487 GLU F CG  1 
ATOM   3261 C CD  . GLU A 1 452 ? 193.34900 364.04300 29.43300  1.000 47.88406  ? 487 GLU F CD  1 
ATOM   3262 O OE1 . GLU A 1 452 ? 193.79300 362.91400 29.17300  1.000 46.47221  ? 487 GLU F OE1 1 
ATOM   3263 O OE2 . GLU A 1 452 ? 194.02100 365.08200 29.35300  1.000 51.33097  ? 487 GLU F OE2 1 
ATOM   3264 N N   . PHE A 1 453 ? 190.48300 361.70700 26.04100  1.000 40.17025  ? 488 PHE F N   1 
ATOM   3265 C CA  . PHE A 1 453 ? 189.67800 360.87600 25.17500  1.000 43.11419  ? 488 PHE F CA  1 
ATOM   3266 C C   . PHE A 1 453 ? 189.48000 359.46000 25.68300  1.000 40.92018  ? 488 PHE F C   1 
ATOM   3267 O O   . PHE A 1 453 ? 188.47800 358.83300 25.32700  1.000 43.58690  ? 488 PHE F O   1 
ATOM   3268 C CB  . PHE A 1 453 ? 190.40100 360.87400 23.81100  1.000 47.42871  ? 488 PHE F CB  1 
ATOM   3269 C CG  . PHE A 1 453 ? 190.33500 359.58300 23.04300  1.000 52.48535  ? 488 PHE F CG  1 
ATOM   3270 C CD1 . PHE A 1 453 ? 189.27700 359.32500 22.16800  1.000 57.84726  ? 488 PHE F CD1 1 
ATOM   3271 C CD2 . PHE A 1 453 ? 191.33200 358.63300 23.19200  1.000 50.97477  ? 488 PHE F CD2 1 
ATOM   3272 C CE1 . PHE A 1 453 ? 189.21700 358.12200 21.44300  1.000 64.93404  ? 488 PHE F CE1 1 
ATOM   3273 C CE2 . PHE A 1 453 ? 191.28900 357.43200 22.48800  1.000 53.30891  ? 488 PHE F CE2 1 
ATOM   3274 C CZ  . PHE A 1 453 ? 190.23300 357.17000 21.60900  1.000 61.15081  ? 488 PHE F CZ  1 
ATOM   3275 N N   . ASP A 1 454 ? 190.27900 359.04300 26.64800  1.000 37.90177  ? 489 ASP F N   1 
ATOM   3276 C CA  . ASP A 1 454 ? 190.29400 357.71600 27.26000  1.000 43.69918  ? 489 ASP F CA  1 
ATOM   3277 C C   . ASP A 1 454 ? 190.91200 357.75800 28.63100  1.000 42.15313  ? 489 ASP F C   1 
ATOM   3278 O O   . ASP A 1 454 ? 192.00100 357.22100 28.80300  1.000 44.93520  ? 489 ASP F O   1 
ATOM   3279 C CB  . ASP A 1 454 ? 191.05800 356.67300 26.44700  1.000 47.18433  ? 489 ASP F CB  1 
ATOM   3280 C CG  . ASP A 1 454 ? 190.53400 355.23100 26.68000  1.000 55.23028  ? 489 ASP F CG  1 
ATOM   3281 O OD1 . ASP A 1 454 ? 189.73900 354.99800 27.62800  1.000 50.57716  ? 489 ASP F OD1 1 
ATOM   3282 O OD2 . ASP A 1 454 ? 191.03200 354.30900 25.99500  1.000 56.54910  ? 489 ASP F OD2 1 
ATOM   3283 N N   . ALA A 1 455 ? 190.35600 358.52800 29.53800  1.000 42.98379  ? 490 ALA F N   1 
ATOM   3284 C CA  . ALA A 1 455 ? 191.01700 358.68400 30.80900  1.000 41.13130  ? 490 ALA F CA  1 
ATOM   3285 C C   . ALA A 1 455 ? 190.35700 357.79400 31.87000  1.000 41.41167  ? 490 ALA F C   1 
ATOM   3286 O O   . ALA A 1 455 ? 189.57200 356.87800 31.58300  1.000 43.05631  ? 490 ALA F O   1 
ATOM   3287 C CB  . ALA A 1 455 ? 191.05700 360.15700 31.20500  1.000 38.48270  ? 490 ALA F CB  1 
ATOM   3288 N N   . SER A 1 456 ? 190.64300 358.11000 33.11600  1.000 38.07053  ? 491 SER F N   1 
ATOM   3289 C CA  . SER A 1 456 ? 190.14800 357.39900 34.27800  1.000 43.18430  ? 491 SER F CA  1 
ATOM   3290 C C   . SER A 1 456 ? 190.03700 358.37900 35.41300  1.000 39.43273  ? 491 SER F C   1 
ATOM   3291 O O   . SER A 1 456 ? 190.62600 359.45900 35.38200  1.000 41.58853  ? 491 SER F O   1 
ATOM   3292 C CB  . SER A 1 456 ? 191.06200 356.24000 34.68000  1.000 39.66376  ? 491 SER F CB  1 
ATOM   3293 O OG  . SER A 1 456 ? 192.11200 356.75500 35.46400  1.000 45.50351  ? 491 SER F OG  1 
ATOM   3294 N N   . ILE A 1 457 ? 189.26500 357.99700 36.41600  1.000 39.09416  ? 492 ILE F N   1 
ATOM   3295 C CA  . ILE A 1 457 ? 189.08900 358.87500 37.56000  1.000 37.46517  ? 492 ILE F CA  1 
ATOM   3296 C C   . ILE A 1 457 ? 190.46400 359.18300 38.18500  1.000 40.76105  ? 492 ILE F C   1 
ATOM   3297 O O   . ILE A 1 457 ? 190.78600 360.34900 38.47200  1.000 39.51333  ? 492 ILE F O   1 
ATOM   3298 C CB  . ILE A 1 457 ? 188.15900 358.17400 38.56700  1.000 43.64398  ? 492 ILE F CB  1 
ATOM   3299 C CG1 . ILE A 1 457 ? 186.68500 358.34500 38.16600  1.000 43.51535  ? 492 ILE F CG1 1 
ATOM   3300 C CG2 . ILE A 1 457 ? 188.36400 358.76000 39.96700  1.000 42.92050  ? 492 ILE F CG2 1 
ATOM   3301 C CD1 . ILE A 1 457 ? 186.14900 359.71600 38.27200  1.000 41.62022  ? 492 ILE F CD1 1 
ATOM   3302 N N   . SER A 1 458 ? 191.28300 358.14800 38.44500  1.000 40.16499  ? 493 SER F N   1 
ATOM   3303 C CA  . SER A 1 458 ? 192.63100 358.37800 38.99900  1.000 47.15217  ? 493 SER F CA  1 
ATOM   3304 C C   . SER A 1 458 ? 193.56900 359.07900 38.01900  1.000 46.30140  ? 493 SER F C   1 
ATOM   3305 O O   . SER A 1 458 ? 194.40400 359.88400 38.43500  1.000 45.50582  ? 493 SER F O   1 
ATOM   3306 C CB  . SER A 1 458 ? 193.28600 357.05300 39.42100  1.000 44.19940  ? 493 SER F CB  1 
ATOM   3307 O OG  . SER A 1 458 ? 192.53200 356.43500 40.44500  1.000 53.02173  ? 493 SER F OG  1 
ATOM   3308 N N   . GLN A 1 459 ? 193.37700 358.86700 36.71600  1.000 46.59352  ? 494 GLN F N   1 
ATOM   3309 C CA  . GLN A 1 459 ? 194.18200 359.56300 35.71500  1.000 49.16585  ? 494 GLN F CA  1 
ATOM   3310 C C   . GLN A 1 459 ? 193.90000 361.05500 35.78900  1.000 50.93197  ? 494 GLN F C   1 
ATOM   3311 O O   . GLN A 1 459 ? 194.82300 361.88700 35.74100  1.000 48.86085  ? 494 GLN F O   1 
ATOM   3312 C CB  . GLN A 1 459 ? 193.85800 358.99100 34.34500  1.000 51.91956  ? 494 GLN F CB  1 
ATOM   3313 C CG  . GLN A 1 459 ? 194.72100 357.86000 33.90000  1.000 45.01511  ? 494 GLN F CG  1 
ATOM   3314 C CD  . GLN A 1 459 ? 194.47000 357.54700 32.43100  1.000 51.47581  ? 494 GLN F CD  1 
ATOM   3315 O OE1 . GLN A 1 459 ? 193.71800 356.62200 32.13400  1.000 52.42064  ? 494 GLN F OE1 1 
ATOM   3316 N NE2 . GLN A 1 459 ? 195.05100 358.32700 31.51800  1.000 50.15605  ? 494 GLN F NE2 1 
ATOM   3317 N N   . VAL A 1 460 ? 192.61800 361.41300 35.90400  1.000 47.57675  ? 495 VAL F N   1 
ATOM   3318 C CA  . VAL A 1 460 ? 192.27600 362.82900 35.97800  1.000 46.94504  ? 495 VAL F CA  1 
ATOM   3319 C C   . VAL A 1 460 ? 192.79400 363.40200 37.28400  1.000 46.14872  ? 495 VAL F C   1 
ATOM   3320 O O   . VAL A 1 460 ? 193.31100 364.52100 37.31800  1.000 48.21453  ? 495 VAL F O   1 
ATOM   3321 C CB  . VAL A 1 460 ? 190.75900 363.02600 35.83300  1.000 39.00992  ? 495 VAL F CB  1 
ATOM   3322 C CG1 . VAL A 1 460 ? 190.39400 364.46600 36.07400  1.000 42.66341  ? 495 VAL F CG1 1 
ATOM   3323 C CG2 . VAL A 1 460 ? 190.37600 362.70100 34.42400  1.000 43.62366  ? 495 VAL F CG2 1 
ATOM   3324 N N   . ASN A 1 461 ? 192.66700 362.65700 38.38300  1.000 46.62283  ? 496 ASN F N   1 
ATOM   3325 C CA  . ASN A 1 461 ? 193.15900 363.21400 39.64000  1.000 54.33219  ? 496 ASN F CA  1 
ATOM   3326 C C   . ASN A 1 461 ? 194.67000 363.42100 39.59600  1.000 59.89787  ? 496 ASN F C   1 
ATOM   3327 O O   . ASN A 1 461 ? 195.17900 364.38700 40.16700  1.000 61.24642  ? 496 ASN F O   1 
ATOM   3328 C CB  . ASN A 1 461 ? 192.77500 362.36000 40.85300  1.000 51.61246  ? 496 ASN F CB  1 
ATOM   3329 C CG  . ASN A 1 461 ? 191.30600 362.49100 41.22600  1.000 53.80534  ? 496 ASN F CG  1 
ATOM   3330 O OD1 . ASN A 1 461 ? 190.68800 363.53600 41.00400  1.000 53.44712  ? 496 ASN F OD1 1 
ATOM   3331 N ND2 . ASN A 1 461 ? 190.74900 361.45100 41.83200  1.000 54.67711  ? 496 ASN F ND2 1 
ATOM   3332 N N   . GLU A 1 462 ? 195.41000 362.51500 38.94500  1.000 59.08437  ? 497 GLU F N   1 
ATOM   3333 C CA  . GLU A 1 462 ? 196.85200 362.71900 38.83700  1.000 64.97931  ? 497 GLU F CA  1 
ATOM   3334 C C   . GLU A 1 462 ? 197.20700 363.90900 37.94500  1.000 62.84589  ? 497 GLU F C   1 
ATOM   3335 O O   . GLU A 1 462 ? 198.09400 364.69900 38.29500  1.000 65.26311  ? 497 GLU F O   1 
ATOM   3336 C CB  . GLU A 1 462 ? 197.50600 361.40600 38.36300  1.000 65.92421  ? 497 GLU F CB  1 
ATOM   3337 C CG  . GLU A 1 462 ? 198.93000 361.45000 37.75300  1.000 77.40837  ? 497 GLU F CG  1 
ATOM   3338 C CD  . GLU A 1 462 ? 199.30200 360.13300 37.00900  1.000 84.72137  ? 497 GLU F CD  1 
ATOM   3339 O OE1 . GLU A 1 462 ? 199.72800 359.16000 37.68300  1.000 83.76617  ? 497 GLU F OE1 1 
ATOM   3340 O OE2 . GLU A 1 462 ? 199.14000 360.06300 35.75600  1.000 79.82512  ? 497 GLU F OE2 1 
ATOM   3341 N N   . LYS A 1 463 ? 196.46500 364.13100 36.85600  1.000 57.69661  ? 498 LYS F N   1 
ATOM   3342 C CA  . LYS A 1 463 ? 196.73100 365.33200 36.05900  1.000 63.65009  ? 498 LYS F CA  1 
ATOM   3343 C C   . LYS A 1 463 ? 196.39300 366.60700 36.82900  1.000 64.55196  ? 498 LYS F C   1 
ATOM   3344 O O   . LYS A 1 463 ? 197.09600 367.61900 36.70100  1.000 70.01231  ? 498 LYS F O   1 
ATOM   3345 C CB  . LYS A 1 463 ? 195.96700 365.29200 34.73900  1.000 57.90357  ? 498 LYS F CB  1 
ATOM   3346 C CG  . LYS A 1 463 ? 196.75700 364.68300 33.61000  1.000 63.24096  ? 498 LYS F CG  1 
ATOM   3347 C CD  . LYS A 1 463 ? 195.94400 364.58000 32.32900  1.000 58.88458  ? 498 LYS F CD  1 
ATOM   3348 C CE  . LYS A 1 463 ? 196.85300 364.71100 31.10300  1.000 66.76893  ? 498 LYS F CE  1 
ATOM   3349 N NZ  . LYS A 1 463 ? 196.49900 363.75100 29.99300  1.000 63.48941  ? 498 LYS F NZ  1 
ATOM   3350 N N   . ILE A 1 464 ? 195.42400 366.53000 37.74100  1.000 61.55409  ? 499 ILE F N   1 
ATOM   3351 C CA  . ILE A 1 464 ? 195.05900 367.68300 38.56300  1.000 64.69181  ? 499 ILE F CA  1 
ATOM   3352 C C   . ILE A 1 464 ? 196.08400 367.91900 39.65400  1.000 68.94485  ? 499 ILE F C   1 
ATOM   3353 O O   . ILE A 1 464 ? 196.39800 369.06600 39.98000  1.000 75.56635  ? 499 ILE F O   1 
ATOM   3354 C CB  . ILE A 1 464 ? 193.65400 367.47200 39.15700  1.000 55.70488  ? 499 ILE F CB  1 
ATOM   3355 C CG1 . ILE A 1 464 ? 192.60500 367.34900 38.04100  1.000 53.78910  ? 499 ILE F CG1 1 
ATOM   3356 C CG2 . ILE A 1 464 ? 193.32900 368.52000 40.22700  1.000 52.55516  ? 499 ILE F CG2 1 
ATOM   3357 C CD1 . ILE A 1 464 ? 191.20400 367.06600 38.55400  1.000 45.31614  ? 499 ILE F CD1 1 
ATOM   3358 N N   . ASN A 1 465 ? 196.63300 366.85100 40.21900  1.000 68.75843  ? 500 ASN F N   1 
ATOM   3359 C CA  . ASN A 1 465 ? 197.68500 366.99000 41.21700  1.000 75.24520  ? 500 ASN F CA  1 
ATOM   3360 C C   . ASN A 1 465 ? 198.93200 367.59900 40.58900  1.000 79.56643  ? 500 ASN F C   1 
ATOM   3361 O O   . ASN A 1 465 ? 199.58400 368.46500 41.19700  1.000 83.52208  ? 500 ASN F O   1 
ATOM   3362 C CB  . ASN A 1 465 ? 197.97500 365.60300 41.78700  1.000 72.88767  ? 500 ASN F CB  1 
ATOM   3363 C CG  . ASN A 1 465 ? 196.92900 365.15300 42.78500  1.000 80.74463  ? 500 ASN F CG  1 
ATOM   3364 O OD1 . ASN A 1 465 ? 195.84000 365.72700 42.85000  1.000 78.46031  ? 500 ASN F OD1 1 
ATOM   3365 N ND2 . ASN A 1 465 ? 197.21700 364.04900 43.49900  1.000 90.79457  ? 500 ASN F ND2 1 
ATOM   3366 N N   . GLN A 1 466 ? 199.15500 367.30600 39.30400  1.000 79.25492  ? 501 GLN F N   1 
ATOM   3367 C CA  . GLN A 1 466 ? 200.29100 367.88400 38.59600  1.000 84.88662  ? 501 GLN F CA  1 
ATOM   3368 C C   . GLN A 1 466 ? 200.04700 369.33900 38.24100  1.000 91.97186  ? 501 GLN F C   1 
ATOM   3369 O O   . GLN A 1 466 ? 200.97100 370.16600 38.34100  1.000 97.99337  ? 501 GLN F O   1 
ATOM   3370 C CB  . GLN A 1 466 ? 200.52100 367.11700 37.29000  1.000 81.98146  ? 501 GLN F CB  1 
ATOM   3371 C CG  . GLN A 1 466 ? 200.94600 365.66800 37.42800  1.000 84.49831  ? 501 GLN F CG  1 
ATOM   3372 C CD  . GLN A 1 466 ? 201.05500 364.98900 36.07600  1.000 86.34106  ? 501 GLN F CD  1 
ATOM   3373 O OE1 . GLN A 1 466 ? 201.02900 365.65400 35.03800  1.000 91.47564  ? 501 GLN F OE1 1 
ATOM   3374 N NE2 . GLN A 1 466 ? 201.16400 363.66000 36.07900  1.000 85.73200  ? 501 GLN F NE2 1 
ATOM   3375 N N   . SER A 1 467 ? 198.79300 369.70200 37.96600  1.000 89.22962  ? 502 SER F N   1 
ATOM   3376 C CA  . SER A 1 467 ? 198.54700 371.10200 37.66900  1.000 91.13973  ? 502 SER F CA  1 
ATOM   3377 C C   . SER A 1 467 ? 198.51200 371.93000 38.94000  1.000 92.46270  ? 502 SER F C   1 
ATOM   3378 O O   . SER A 1 467 ? 198.91700 373.10300 38.91400  1.000 99.39578  ? 502 SER F O   1 
ATOM   3379 C CB  . SER A 1 467 ? 197.23100 371.27000 36.90400  1.000 79.87260  ? 502 SER F CB  1 
ATOM   3380 O OG  . SER A 1 467 ? 197.35100 370.78300 35.58400  1.000 81.57716  ? 502 SER F OG  1 
ATOM   3381 N N   . LEU A 1 468 ? 198.19600 371.30800 40.07900  1.000 87.77423  ? 503 LEU F N   1 
ATOM   3382 C CA  . LEU A 1 468 ? 198.25300 372.09200 41.29400  1.000 90.31964  ? 503 LEU F CA  1 
ATOM   3383 C C   . LEU A 1 468 ? 199.68800 372.26700 41.76300  1.000 101.67236 ? 503 LEU F C   1 
ATOM   3384 O O   . LEU A 1 468 ? 199.99700 373.28700 42.39500  1.000 107.19919 ? 503 LEU F O   1 
ATOM   3385 C CB  . LEU A 1 468 ? 197.42900 371.40100 42.37800  1.000 82.93473  ? 503 LEU F CB  1 
ATOM   3386 C CG  . LEU A 1 468 ? 195.91000 371.50500 42.27600  1.000 82.57973  ? 503 LEU F CG  1 
ATOM   3387 C CD1 . LEU A 1 468 ? 195.25200 370.75600 43.41900  1.000 79.72689  ? 503 LEU F CD1 1 
ATOM   3388 C CD2 . LEU A 1 468 ? 195.49400 372.95900 42.29300  1.000 75.81015  ? 503 LEU F CD2 1 
ATOM   3389 N N   . ALA A 1 469 ? 200.58800 371.30400 41.48500  1.000 103.20790 ? 504 ALA F N   1 
ATOM   3390 C CA  . ALA A 1 469 ? 201.98100 371.59800 41.83000  1.000 107.10688 ? 504 ALA F CA  1 
ATOM   3391 C C   . ALA A 1 469 ? 202.60800 372.64500 40.89500  1.000 113.16978 ? 504 ALA F C   1 
ATOM   3392 O O   . ALA A 1 469 ? 203.40600 373.47700 41.35300  1.000 116.13188 ? 504 ALA F O   1 
ATOM   3393 C CB  . ALA A 1 469 ? 202.81100 370.31400 41.82300  1.000 97.86268  ? 504 ALA F CB  1 
ATOM   3394 N N   . PHE A 1 470 ? 202.23500 372.65600 39.59300  1.000 110.71356 ? 505 PHE F N   1 
ATOM   3395 C CA  . PHE A 1 470 ? 202.74600 373.69900 38.68900  1.000 111.89512 ? 505 PHE F CA  1 
ATOM   3396 C C   . PHE A 1 470 ? 202.17100 375.08400 38.96300  1.000 114.38897 ? 505 PHE F C   1 
ATOM   3397 O O   . PHE A 1 470 ? 202.77200 376.08400 38.55100  1.000 113.42066 ? 505 PHE F O   1 
ATOM   3398 C CB  . PHE A 1 470 ? 202.50100 373.40200 37.19900  1.000 113.52948 ? 505 PHE F CB  1 
ATOM   3399 C CG  . PHE A 1 470 ? 203.12000 372.12700 36.68800  1.000 117.60571 ? 505 PHE F CG  1 
ATOM   3400 C CD1 . PHE A 1 470 ? 204.29300 371.62300 37.23800  1.000 114.44139 ? 505 PHE F CD1 1 
ATOM   3401 C CD2 . PHE A 1 470 ? 202.58200 371.49600 35.56300  1.000 119.36617 ? 505 PHE F CD2 1 
ATOM   3402 C CE1 . PHE A 1 470 ? 204.87700 370.46400 36.72600  1.000 116.55309 ? 505 PHE F CE1 1 
ATOM   3403 C CE2 . PHE A 1 470 ? 203.16300 370.34200 35.04100  1.000 117.04143 ? 505 PHE F CE2 1 
ATOM   3404 C CZ  . PHE A 1 470 ? 204.31200 369.82500 35.62400  1.000 116.30011 ? 505 PHE F CZ  1 
ATOM   3405 N N   . ILE A 1 471 ? 201.03100 375.16400 39.65000  1.000 114.06162 ? 506 ILE F N   1 
ATOM   3406 C CA  . ILE A 1 471 ? 200.41600 376.45000 39.97100  1.000 116.42406 ? 506 ILE F CA  1 
ATOM   3407 C C   . ILE A 1 471 ? 200.73200 376.93100 41.38100  1.000 117.87509 ? 506 ILE F C   1 
ATOM   3408 O O   . ILE A 1 471 ? 200.71000 378.14100 41.63900  1.000 120.73736 ? 506 ILE F O   1 
ATOM   3409 C CB  . ILE A 1 471 ? 198.89500 376.41700 39.70600  1.000 114.41834 ? 506 ILE F CB  1 
ATOM   3410 C CG1 . ILE A 1 471 ? 198.62400 375.84600 38.30100  1.000 108.20379 ? 506 ILE F CG1 1 
ATOM   3411 C CG2 . ILE A 1 471 ? 198.27800 377.80900 39.87400  1.000 110.98692 ? 506 ILE F CG2 1 
ATOM   3412 C CD1 . ILE A 1 471 ? 197.15900 375.73500 37.92600  1.000 96.92275  ? 506 ILE F CD1 1 
ATOM   3413 N N   . ARG A 1 472 ? 201.02500 376.02000 42.30800  1.000 114.71129 ? 507 ARG F N   1 
ATOM   3414 C CA  . ARG A 1 472 ? 201.31700 376.49500 43.65500  1.000 120.19569 ? 507 ARG F CA  1 
ATOM   3415 C C   . ARG A 1 472 ? 202.57300 377.36500 43.65900  1.000 123.39123 ? 507 ARG F C   1 
ATOM   3416 O O   . ARG A 1 472 ? 202.59400 378.43200 44.28900  1.000 123.31504 ? 507 ARG F O   1 
ATOM   3417 C CB  . ARG A 1 472 ? 201.47400 375.33600 44.63000  1.000 118.39763 ? 507 ARG F CB  1 
ATOM   3418 C CG  . ARG A 1 472 ? 202.11200 375.81300 45.91100  1.000 123.19060 ? 507 ARG F CG  1 
ATOM   3419 C CD  . ARG A 1 472 ? 202.31400 374.70900 46.90000  1.000 126.82007 ? 507 ARG F CD  1 
ATOM   3420 N NE  . ARG A 1 472 ? 203.72000 374.32800 46.91900  1.000 133.59673 ? 507 ARG F NE  1 
ATOM   3421 C CZ  . ARG A 1 472 ? 204.27200 373.52000 47.81400  1.000 132.93157 ? 507 ARG F CZ  1 
ATOM   3422 N NH1 . ARG A 1 472 ? 203.55900 372.98000 48.79100  1.000 132.83668 ? 507 ARG F NH1 1 
ATOM   3423 N NH2 . ARG A 1 472 ? 205.57300 373.25200 47.73000  1.000 129.48891 ? 507 ARG F NH2 1 
ATOM   3424 N N   . LYS A 1 473 ? 203.62900 376.93500 42.97000  1.000 122.18512 ? 508 LYS F N   1 
ATOM   3425 C CA  . LYS A 1 473 ? 204.84800 377.73800 42.93700  1.000 119.63384 ? 508 LYS F CA  1 
ATOM   3426 C C   . LYS A 1 473 ? 204.59400 379.03400 42.17600  1.000 119.29499 ? 508 LYS F C   1 
ATOM   3427 O O   . LYS A 1 473 ? 204.84400 379.11500 40.97300  1.000 119.26292 ? 508 LYS F O   1 
ATOM   3428 C CB  . LYS A 1 473 ? 206.00500 376.99600 42.27200  1.000 119.02382 ? 508 LYS F CB  1 
ATOM   3429 C CG  . LYS A 1 473 ? 206.80200 376.06800 43.16900  1.000 118.17167 ? 508 LYS F CG  1 
ATOM   3430 C CD  . LYS A 1 473 ? 206.05600 374.80000 43.49900  1.000 116.97022 ? 508 LYS F CD  1 
ATOM   3431 C CE  . LYS A 1 473 ? 206.96400 373.86400 44.26700  1.000 113.38173 ? 508 LYS F CE  1 
ATOM   3432 N NZ  . LYS A 1 473 ? 206.30800 372.56400 44.54000  1.000 118.90916 ? 508 LYS F NZ  1 
HETATM 3433 C C1  . PEG B 2 .   ? 182.77400 351.19900 32.74500  1.000 52.19023  ? 601 PEG F C1  1 
HETATM 3434 O O1  . PEG B 2 .   ? 182.06200 352.39600 33.18400  1.000 38.06753  ? 601 PEG F O1  1 
HETATM 3435 C C2  . PEG B 2 .   ? 182.47000 349.85700 33.45200  1.000 37.95572  ? 601 PEG F C2  1 
HETATM 3436 O O2  . PEG B 2 .   ? 181.86800 350.04600 34.77600  1.000 53.89343  ? 601 PEG F O2  1 
HETATM 3437 C C3  . PEG B 2 .   ? 180.96200 349.03800 35.23400  1.000 30.86227  ? 601 PEG F C3  1 
HETATM 3438 C C4  . PEG B 2 .   ? 179.77600 348.94400 34.30600  1.000 47.42070  ? 601 PEG F C4  1 
HETATM 3439 O O4  . PEG B 2 .   ? 179.14300 347.66600 34.25400  1.000 38.12412  ? 601 PEG F O4  1 
HETATM 3440 H H11 . PEG B 2 .   ? 183.72100 351.37300 32.85600  1.000 62.72182  ? 601 PEG F H11 1 
HETATM 3441 H H12 . PEG B 2 .   ? 182.57500 351.07800 31.80300  1.000 62.72182  ? 601 PEG F H12 1 
HETATM 3442 H HO1 . PEG B 2 .   ? 182.13100 353.06300 32.65700  1.000 45.77458  ? 601 PEG F HO1 1 
HETATM 3443 H H21 . PEG B 2 .   ? 183.29900 349.36400 33.55400  1.000 45.64041  ? 601 PEG F H21 1 
HETATM 3444 H H22 . PEG B 2 .   ? 181.85700 349.34700 32.90100  1.000 45.64041  ? 601 PEG F H22 1 
HETATM 3445 H H31 . PEG B 2 .   ? 180.65400 349.26400 36.12500  1.000 37.12827  ? 601 PEG F H31 1 
HETATM 3446 H H32 . PEG B 2 .   ? 181.41900 348.18200 35.25600  1.000 37.12827  ? 601 PEG F H32 1 
HETATM 3447 H H41 . PEG B 2 .   ? 180.07600 349.16600 33.41100  1.000 56.99838  ? 601 PEG F H41 1 
HETATM 3448 H H42 . PEG B 2 .   ? 179.11600 349.59400 34.59600  1.000 56.99838  ? 601 PEG F H42 1 
HETATM 3449 H HO4 . PEG B 2 .   ? 178.31300 347.69300 34.44000  1.000 45.84250  ? 601 PEG F HO4 1 
HETATM 3450 C C1  . EDO C 3 .   ? 178.04200 355.33200 41.18600  1.000 44.21001  ? 602 EDO F C1  1 
HETATM 3451 O O1  . EDO C 3 .   ? 179.08400 356.30000 41.41100  1.000 42.97653  ? 602 EDO F O1  1 
HETATM 3452 C C2  . EDO C 3 .   ? 177.35100 355.46800 39.82400  1.000 41.74384  ? 602 EDO F C2  1 
HETATM 3453 O O2  . EDO C 3 .   ? 178.30000 355.59700 38.75800  1.000 36.49925  ? 602 EDO F O2  1 
HETATM 3454 H H11 . EDO C 3 .   ? 177.29100 355.43600 41.97200  1.000 53.14556  ? 602 EDO F H11 1 
HETATM 3455 H H12 . EDO C 3 .   ? 178.47200 354.33000 41.26300  1.000 53.14556  ? 602 EDO F H12 1 
HETATM 3456 H HO1 . EDO C 3 .   ? 179.54000 356.09500 42.23900  1.000 51.66538  ? 602 EDO F HO1 1 
HETATM 3457 H H21 . EDO C 3 .   ? 176.70100 356.34400 39.83600  1.000 50.18615  ? 602 EDO F H21 1 
HETATM 3458 H H22 . EDO C 3 .   ? 176.72700 354.58900 39.64700  1.000 50.18615  ? 602 EDO F H22 1 
HETATM 3459 H HO2 . EDO C 3 .   ? 177.84300 355.52600 37.90900  1.000 43.89264  ? 602 EDO F HO2 1 
HETATM 3460 C C1  . NAG D 4 .   ? 196.38100 363.40000 44.50400  1.000 95.88682  ? 603 NAG F C1  1 
HETATM 3461 C C2  . NAG D 4 .   ? 196.49300 361.86200 44.50800  1.000 96.60870  ? 603 NAG F C2  1 
HETATM 3462 C C3  . NAG D 4 .   ? 195.64000 361.28700 45.64700  1.000 102.53663 ? 603 NAG F C3  1 
HETATM 3463 C C4  . NAG D 4 .   ? 196.00900 361.93600 46.98100  1.000 105.20779 ? 603 NAG F C4  1 
HETATM 3464 C C5  . NAG D 4 .   ? 195.95700 363.46400 46.87500  1.000 102.14236 ? 603 NAG F C5  1 
HETATM 3465 C C6  . NAG D 4 .   ? 196.41600 364.18300 48.12800  1.000 100.71145 ? 603 NAG F C6  1 
HETATM 3466 C C7  . NAG D 4 .   ? 196.89100 360.64200 42.38100  1.000 88.44799  ? 603 NAG F C7  1 
HETATM 3467 C C8  . NAG D 4 .   ? 196.24700 360.09100 41.14000  1.000 77.15299  ? 603 NAG F C8  1 
HETATM 3468 N N2  . NAG D 4 .   ? 196.07400 361.28700 43.23200  1.000 93.32920  ? 603 NAG F N2  1 
HETATM 3469 O O3  . NAG D 4 .   ? 195.81500 359.87300 45.72200  1.000 94.60561  ? 603 NAG F O3  1 
HETATM 3470 O O4  . NAG D 4 .   ? 195.13200 361.49700 48.01600  1.000 105.36795 ? 603 NAG F O4  1 
HETATM 3471 O O5  . NAG D 4 .   ? 196.79200 363.91300 45.79400  1.000 100.88927 ? 603 NAG F O5  1 
HETATM 3472 O O6  . NAG D 4 .   ? 197.57600 363.59700 48.70300  1.000 100.34487 ? 603 NAG F O6  1 
HETATM 3473 O O7  . NAG D 4 .   ? 198.09300 360.51900 42.59500  1.000 88.68207  ? 603 NAG F O7  1 
HETATM 3474 O O   . HOH E 5 .   ? 157.72100 365.45900 25.48800  1.000 38.32771  ? 701 HOH F O   1 
HETATM 3475 O O   . HOH E 5 .   ? 177.82100 338.11500 18.80100  1.000 54.41658  ? 702 HOH F O   1 
HETATM 3476 O O   . HOH E 5 .   ? 186.90900 375.61800 31.39100  1.000 53.75124  ? 703 HOH F O   1 
HETATM 3477 O O   . HOH E 5 .   ? 165.83200 368.47100 34.94300  1.000 51.86229  ? 704 HOH F O   1 
HETATM 3478 O O   . HOH E 5 .   ? 174.70900 365.46900 25.22400  1.000 43.28716  ? 705 HOH F O   1 
HETATM 3479 O O   . HOH E 5 .   ? 173.31900 361.35700 25.64200  1.000 46.84141  ? 706 HOH F O   1 
HETATM 3480 O O   . HOH E 5 .   ? 177.37500 345.73400 23.80400  1.000 43.76678  ? 707 HOH F O   1 
HETATM 3481 O O   . HOH E 5 .   ? 175.83300 344.39800 21.59100  1.000 55.71310  ? 708 HOH F O   1 
HETATM 3482 O O   . HOH E 5 .   ? 191.58900 325.63100 10.94500  1.000 54.26056  ? 709 HOH F O   1 
HETATM 3483 O O   . HOH E 5 .   ? 157.88500 364.28100 23.43700  1.000 41.96962  ? 710 HOH F O   1 
HETATM 3484 O O   . HOH E 5 .   ? 187.46200 354.62200 40.42500  1.000 39.86765  ? 711 HOH F O   1 
HETATM 3485 O O   . HOH E 5 .   ? 190.57600 351.13300 34.68900  1.000 49.87869  ? 712 HOH F O   1 
HETATM 3486 O O   . HOH E 5 .   ? 159.33700 355.11000 37.94400  1.000 52.78348  ? 713 HOH F O   1 
HETATM 3487 O O   . HOH E 5 .   ? 167.60600 374.27800 28.12800  1.000 37.64366  ? 714 HOH F O   1 
HETATM 3488 O O   . HOH E 5 .   ? 162.34400 361.34100 36.85900  1.000 46.91532  ? 715 HOH F O   1 
HETATM 3489 O O   . HOH E 5 .   ? 185.00200 337.54600 27.90100  1.000 32.82499  ? 716 HOH F O   1 
HETATM 3490 O O   . HOH E 5 .   ? 189.12800 362.22800 39.19200  1.000 47.37433  ? 717 HOH F O   1 
HETATM 3491 O O   . HOH E 5 .   ? 156.84500 354.63700 23.75100  1.000 42.44535  ? 718 HOH F O   1 
HETATM 3492 O O   . HOH E 5 .   ? 178.01000 362.26900 44.10100  1.000 46.22065  ? 719 HOH F O   1 
HETATM 3493 O O   . HOH E 5 .   ? 172.89200 364.55600 36.79600  1.000 39.02603  ? 720 HOH F O   1 
HETATM 3494 O O   . HOH E 5 .   ? 157.85700 358.11200 34.29700  1.000 45.97767  ? 721 HOH F O   1 
HETATM 3495 O O   . HOH E 5 .   ? 175.59900 368.91500 36.07400  1.000 43.32084  ? 722 HOH F O   1 
HETATM 3496 O O   . HOH E 5 .   ? 192.65700 364.97500 23.25100  1.000 44.08826  ? 723 HOH F O   1 
HETATM 3497 O O   . HOH E 5 .   ? 164.182   374.022   17.624    1.000 46.15257  ? 724 HOH F O   1 
HETATM 3498 O O   . HOH E 5 .   ? 183.34800 330.58100 30.46000  1.000 28.80455  ? 725 HOH F O   1 
HETATM 3499 O O   . HOH E 5 .   ? 159.88800 351.66000 34.72100  1.000 49.56942  ? 726 HOH F O   1 
HETATM 3500 O O   . HOH E 5 .   ? 171.45000 341.22400 35.84500  1.000 42.58422  ? 727 HOH F O   1 
HETATM 3501 O O   . HOH E 5 .   ? 173.46600 331.47000 4.14500   1.000 55.18814  ? 728 HOH F O   1 
HETATM 3502 O O   . HOH E 5 .   ? 185.61800 331.73100 23.31300  1.000 38.55641  ? 729 HOH F O   1 
HETATM 3503 O O   . HOH E 5 .   ? 170.05600 338.55900 35.92700  1.000 42.31012  ? 730 HOH F O   1 
HETATM 3504 O O   . HOH E 5 .   ? 184.82600 369.99300 23.09000  1.000 43.12397  ? 731 HOH F O   1 
HETATM 3505 O O   . HOH E 5 .   ? 166.88600 332.04000 4.72200   1.000 63.41428  ? 732 HOH F O   1 
HETATM 3506 O O   . HOH E 5 .   ? 162.49800 368.30000 35.73700  1.000 38.19782  ? 733 HOH F O   1 
HETATM 3507 O O   . HOH E 5 .   ? 163.18100 353.03800 27.39500  1.000 38.03091  ? 734 HOH F O   1 
HETATM 3508 O O   . HOH E 5 .   ? 164.03100 364.07000 37.92000  1.000 50.77527  ? 735 HOH F O   1 
HETATM 3509 O O   . HOH E 5 .   ? 161.201   360.744   15.825    1.000 43.06994  ? 736 HOH F O   1 
HETATM 3510 O O   . HOH E 5 .   ? 190.10500 341.09100 40.39300  1.000 33.80946  ? 737 HOH F O   1 
HETATM 3511 O O   . HOH E 5 .   ? 177.19700 336.04600 39.56100  1.000 45.34554  ? 738 HOH F O   1 
HETATM 3512 O O   . HOH E 5 .   ? 181.52300 334.67800 37.64200  1.000 40.22668  ? 739 HOH F O   1 
HETATM 3513 O O   . HOH E 5 .   ? 194.67900 356.84400 28.90100  1.000 47.55077  ? 740 HOH F O   1 
HETATM 3514 O O   . HOH E 5 .   ? 180.37800 354.96800 27.41300  1.000 45.99051  ? 741 HOH F O   1 
HETATM 3515 O O   . HOH E 5 .   ? 158.670   360.235   15.250    1.000 48.76765  ? 742 HOH F O   1 
HETATM 3516 O O   . HOH E 5 .   ? 185.76600 349.87000 32.33300  1.000 41.17428  ? 743 HOH F O   1 
HETATM 3517 O O   . HOH E 5 .   ? 175.24300 345.74300 37.91600  1.000 48.69474  ? 744 HOH F O   1 
HETATM 3518 O O   . HOH E 5 .   ? 182.54200 364.09100 27.97900  1.000 37.82172  ? 745 HOH F O   1 
HETATM 3519 O O   . HOH E 5 .   ? 176.48700 373.28600 30.00300  1.000 43.36535  ? 746 HOH F O   1 
HETATM 3520 O O   . HOH E 5 .   ? 184.18000 350.69600 25.07200  1.000 46.10659  ? 747 HOH F O   1 
HETATM 3521 O O   . HOH E 5 .   ? 170.39000 367.41200 20.20900  1.000 37.27004  ? 748 HOH F O   1 
HETATM 3522 O O   . HOH E 5 .   ? 173.34000 367.07200 36.09500  1.000 33.27426  ? 749 HOH F O   1 
HETATM 3523 O O   . HOH E 5 .   ? 168.56600 348.31000 26.74100  1.000 47.19553  ? 750 HOH F O   1 
HETATM 3524 O O   . HOH E 5 .   ? 188.591   338.265   26.531    1.000 37.58992  ? 751 HOH F O   1 
HETATM 3525 O O   . HOH E 5 .   ? 161.81700 369.55800 22.35500  1.000 38.11192  ? 752 HOH F O   1 
HETATM 3526 O O   . HOH E 5 .   ? 173.76300 374.33200 29.89000  1.000 40.89414  ? 753 HOH F O   1 
HETATM 3527 O O   . HOH E 5 .   ? 183.20600 341.48600 42.72200  1.000 51.24347  ? 754 HOH F O   1 
HETATM 3528 O O   . HOH E 5 .   ? 174.67800 351.08400 26.14300  1.000 35.27320  ? 755 HOH F O   1 
HETATM 3529 O O   . HOH E 5 .   ? 160.82000 358.61600 36.37100  1.000 46.27732  ? 756 HOH F O   1 
HETATM 3530 O O   . HOH E 5 .   ? 181.51900 337.51600 37.88700  1.000 44.74183  ? 757 HOH F O   1 
HETATM 3531 O O   . HOH E 5 .   ? 162.171   368.064   13.676    1.000 31.33537  ? 758 HOH F O   1 
HETATM 3532 O O   . HOH E 5 .   ? 182.66300 371.90000 38.56600  1.000 45.83390  ? 759 HOH F O   1 
HETATM 3533 O O   . HOH E 5 .   ? 169.49300 366.10400 37.65400  1.000 47.89790  ? 760 HOH F O   1 
HETATM 3534 O O   . HOH E 5 .   ? 189.74300 369.89300 38.30300  1.000 48.06721  ? 761 HOH F O   1 
HETATM 3535 O O   . HOH E 5 .   ? 191.32000 345.69400 43.28800  1.000 55.04647  ? 762 HOH F O   1 
HETATM 3536 O O   . HOH E 5 .   ? 162.388   372.149   34.401    1.000 37.30787  ? 763 HOH F O   1 
HETATM 3537 O O   . HOH E 5 .   ? 175.33700 362.76200 46.69700  1.000 56.26059  ? 764 HOH F O   1 
HETATM 3538 O O   . HOH E 5 .   ? 167.21300 356.19500 45.53400  1.000 59.50019  ? 765 HOH F O   1 
HETATM 3539 O O   . HOH E 5 .   ? 179.53500 344.66900 42.77900  1.000 50.45314  ? 766 HOH F O   1 
HETATM 3540 O O   . HOH E 5 .   ? 173.70900 358.93500 41.96400  1.000 40.79342  ? 767 HOH F O   1 
HETATM 3541 O O   . HOH E 5 .   ? 172.73400 352.67300 25.57700  1.000 43.57290  ? 768 HOH F O   1 
HETATM 3542 O O   . HOH E 5 .   ? 165.42200 373.29300 21.58500  1.000 33.54170  ? 769 HOH F O   1 
HETATM 3543 O O   . HOH E 5 .   ? 180.20700 362.04200 25.52800  1.000 46.78967  ? 770 HOH F O   1 
HETATM 3544 O O   . HOH E 5 .   ? 178.33100 359.32200 31.90700  1.000 30.00963  ? 771 HOH F O   1 
HETATM 3545 O O   . HOH E 5 .   ? 185.16600 351.96200 33.94500  1.000 42.03928  ? 772 HOH F O   1 
HETATM 3546 O O   . HOH E 5 .   ? 183.78900 353.59200 25.62800  1.000 54.06220  ? 773 HOH F O   1 
HETATM 3547 O O   . HOH E 5 .   ? 158.550   373.182   26.568    1.000 41.51770  ? 774 HOH F O   1 
HETATM 3548 O O   . HOH E 5 .   ? 164.53700 372.08600 28.54400  1.000 30.33823  ? 775 HOH F O   1 
HETATM 3549 O O   . HOH E 5 .   ? 171.09200 345.60000 23.15300  1.000 50.36755  ? 776 HOH F O   1 
HETATM 3550 O O   . HOH E 5 .   ? 176.66700 328.70100 32.80500  1.000 37.99546  ? 777 HOH F O   1 
HETATM 3551 O O   . HOH E 5 .   ? 181.63100 350.77100 24.45900  1.000 43.76716  ? 778 HOH F O   1 
HETATM 3552 O O   . HOH E 5 .   ? 187.23300 338.93400 38.98000  1.000 30.84396  ? 779 HOH F O   1 
HETATM 3553 O O   . HOH E 5 .   ? 162.88200 356.01700 41.68500  1.000 49.52488  ? 780 HOH F O   1 
HETATM 3554 O O   . HOH E 5 .   ? 168.22500 367.02200 32.19300  1.000 39.72532  ? 781 HOH F O   1 
HETATM 3555 O O   . HOH E 5 .   ? 177.75500 357.91000 43.40900  1.000 54.72779  ? 782 HOH F O   1 
HETATM 3556 O O   . HOH E 5 .   ? 199.64300 362.50900 33.89400  1.000 64.32682  ? 783 HOH F O   1 
HETATM 3557 O O   . HOH E 5 .   ? 170.75700 380.67900 27.79600  1.000 51.25364  ? 784 HOH F O   1 
HETATM 3558 O O   . HOH E 5 .   ? 190.61200 352.92700 42.05800  1.000 53.09292  ? 785 HOH F O   1 
HETATM 3559 O O   . HOH E 5 .   ? 169.43000 372.99400 36.49900  1.000 53.92369  ? 786 HOH F O   1 
HETATM 3560 O O   . HOH E 5 .   ? 165.10800 349.82000 24.93900  1.000 48.72914  ? 787 HOH F O   1 
HETATM 3561 O O   . HOH E 5 .   ? 191.60400 349.49600 37.17500  1.000 55.85887  ? 788 HOH F O   1 
HETATM 3562 O O   . HOH E 5 .   ? 189.65800 369.81300 41.03000  1.000 48.93362  ? 789 HOH F O   1 
HETATM 3563 O O   . HOH E 5 .   ? 159.53700 352.33300 37.37100  1.000 54.02827  ? 790 HOH F O   1 
HETATM 3564 O O   . HOH E 5 .   ? 190.32100 345.74800 39.53000  1.000 45.71598  ? 791 HOH F O   1 
HETATM 3565 O O   . HOH E 5 .   ? 180.16400 331.54600 35.50200  1.000 31.37532  ? 792 HOH F O   1 
HETATM 3566 O O   . HOH E 5 .   ? 189.74800 355.51400 40.83100  1.000 46.82304  ? 793 HOH F O   1 
HETATM 3567 O O   . HOH E 5 .   ? 182.80700 335.82700 3.71900   1.000 59.18560  ? 794 HOH F O   1 
HETATM 3568 O O   . HOH E 5 .   ? 184.01400 336.99500 40.98000  1.000 50.12811  ? 795 HOH F O   1 
HETATM 3569 O O   . HOH E 5 .   ? 187.95700 348.78100 27.75700  1.000 58.24250  ? 796 HOH F O   1 
HETATM 3570 O O   . HOH E 5 .   ? 174.62000 354.66500 26.33900  1.000 32.60255  ? 797 HOH F O   1 
HETATM 3571 O O   . HOH E 5 .   ? 190.327   337.629   34.271    1.000 37.80244  ? 798 HOH F O   1 
HETATM 3572 O O   . HOH E 5 .   ? 187.01400 355.99600 47.86000  1.000 62.48100  ? 799 HOH F O   1 
HETATM 3573 O O   . HOH E 5 .   ? 171.65100 375.90400 22.81000  1.000 41.95198  ? 800 HOH F O   1 
HETATM 3574 O O   . HOH E 5 .   ? 175.48800 370.56300 37.99100  1.000 53.65094  ? 801 HOH F O   1 
HETATM 3575 O O   . HOH E 5 .   ? 159.193   369.091   35.255    1.000 38.86687  ? 802 HOH F O   1 
HETATM 3576 O O   . HOH E 5 .   ? 160.94200 344.46300 37.94000  1.000 52.54001  ? 803 HOH F O   1 
HETATM 3577 O O   . HOH E 5 .   ? 175.16200 353.82200 43.11500  1.000 57.01129  ? 804 HOH F O   1 
HETATM 3578 O O   . HOH E 5 .   ? 175.36800 347.06300 41.62800  1.000 59.11730  ? 805 HOH F O   1 
HETATM 3579 O O   . HOH E 5 .   ? 176.89000 336.22900 4.17200   1.000 55.06383  ? 806 HOH F O   1 
HETATM 3580 O O   . HOH E 5 .   ? 176.369   377.190   21.757    1.000 56.42513  ? 807 HOH F O   1 
HETATM 3581 O O   . HOH E 5 .   ? 160.135   365.329   15.590    1.000 44.95901  ? 808 HOH F O   1 
HETATM 3582 O O   . HOH E 5 .   ? 175.50400 356.89900 43.27800  1.000 52.81324  ? 809 HOH F O   1 
HETATM 3583 O O   . HOH E 5 .   ? 179.21700 333.68300 36.59900  1.000 43.07204  ? 810 HOH F O   1 
HETATM 3584 O O   . HOH E 5 .   ? 190.60400 339.70000 35.77700  1.000 47.03676  ? 811 HOH F O   1 
HETATM 3585 O O   . HOH E 5 .   ? 155.78200 365.47700 21.70200  1.000 45.85190  ? 812 HOH F O   1 
HETATM 3586 O O   . HOH E 5 .   ? 192.444   324.946   13.408    1.000 47.58077  ? 813 HOH F O   1 
HETATM 3587 O O   . HOH E 5 .   ? 165.446   376.051   35.188    1.000 47.58334  ? 814 HOH F O   1 
HETATM 3588 O O   . HOH E 5 .   ? 173.11000 377.82700 23.12500  1.000 46.67667  ? 815 HOH F O   1 
HETATM 3589 O O   . HOH E 5 .   ? 173.201   379.789   21.725    1.000 46.27091  ? 816 HOH F O   1 
HETATM 3590 O O   . HOH E 5 .   ? 170.23300 336.26500 37.52500  1.000 44.76810  ? 817 HOH F O   1 
HETATM 3591 O O   . HOH E 5 .   ? 172.95800 341.87800 37.80100  1.000 53.01832  ? 818 HOH F O   1 
HETATM 3592 O O   . HOH E 5 .   ? 190.06800 339.22100 38.56000  1.000 35.53228  ? 819 HOH F O   1 
HETATM 3593 O O   . HOH E 5 .   ? 168.13500 334.17000 3.67900   1.000 55.47972  ? 820 HOH F O   1 
HETATM 3594 O O   . HOH E 5 .   ? 191.20600 366.72400 44.87500  1.000 66.08913  ? 821 HOH F O   1 
# 
